BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P27361 (379 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4QTB-A nrPDB 791 0.0 5NGU-A nrPDB 650 0.0 4IC8-A nrPDB 352 1e-97 4ZSG-A nrPDB 352 2e-97 2F9G-A nrPDB 349 1e-96 6DTL-A nrPDB 334 3e-92 4EWQ-A nrPDB 332 2e-91 5Z33-A nrPDB 329 1e-90 3OHT-A nrPDB 325 2e-89 3GC9-A nrPDB 322 2e-88 4MYG-A nrPDB 305 2e-83 4QNY-A nrPDB 295 2e-80 1CM8-A nrPDB 292 2e-79 1JNK-A nrPDB 266 1e-71 3OZ6-A nrPDB 266 1e-71 4O2Z-A nrPDB 265 3e-71 2I6L-A nrPDB 264 5e-71 3E7O-A nrPDB 263 1e-70 5AWM-A nrPDB 259 2e-69 3RP9-A nrPDB 257 7e-69 2XS0-A nrPDB 254 4e-68 3FI2-A nrPDB 253 9e-68 3PG1-A nrPDB 248 3e-66 3N9X-A nrPDB 232 2e-61 3NIE-A nrPDB 231 4e-61 2BPM-A nrPDB 201 3e-52 3NIZ-A nrPDB 201 3e-52 1V0B-A nrPDB 193 1e-49 4AU8-A nrPDB 189 2e-48 1UA2-A nrPDB 186 2e-47 6GU6-A nrPDB 185 3e-47 4KRC-A nrPDB 183 8e-47 5AIR-A nrPDB 181 5e-46 5G6V-A nrPDB 181 6e-46 4NST-A nrPDB 180 1e-45 1G3N-A nrPDB 177 5e-45 5EFQ-A nrPDB 175 3e-44 4E7W-A nrPDB 171 6e-43 2W96-B nrPDB 170 9e-43 3GC0-A nrPDB 168 4e-42 3EB0-A nrPDB 163 1e-40 4BBM-A nrPDB 163 1e-40 4CRL-A nrPDB 160 7e-40 3E3P-A nrPDB 160 9e-40 4BGQ-A nrPDB 159 2e-39 4AGU-A nrPDB 156 2e-38 3MIA-A nrPDB 155 3e-38 3ZDU-A nrPDB 149 2e-36 5Y86-A nrPDB 138 4e-33 5ZTN-A nrPDB 134 9e-32 3NCG-A nrPDB 129 2e-30 6O6Q-A nrPDB 129 2e-30 3DFA-A nrPDB 126 1e-29 2YCR-A nrPDB 123 1e-28 5XVU-A nrPDB 122 2e-28 3I6U-A nrPDB 120 1e-27 6EII-A nrPDB 119 2e-27 4MD7-E nrPDB 119 2e-27 5X8I-B nrPDB 117 1e-26 5JN2-A nrPDB 116 1e-26 6HMD-A nrPDB 116 2e-26 2PVN-A nrPDB 115 2e-26 3HZT-A nrPDB 114 5e-26 3DXN-A nrPDB 112 2e-25 6FYV-A nrPDB 110 1e-24 3MA6-A nrPDB 110 1e-24 3LIJ-A nrPDB 109 2e-24 4MVF-A nrPDB 108 4e-24 4NIF-A nrPDB 107 1e-23 1PHK-A nrPDB 106 1e-23 4IAN-A nrPDB 105 3e-23 3Q5I-A nrPDB 105 4e-23 4LFI-A nrPDB 104 5e-23 2WO6-A nrPDB 104 5e-23 4RGJ-A nrPDB 103 8e-23 3RAW-A nrPDB 102 2e-22 6E2O-A nrPDB 101 4e-22 4FG9-A nrPDB 101 5e-22 5FG8-A nrPDB 101 5e-22 3BHH-A nrPDB 101 6e-22 2V7O-A nrPDB 101 7e-22 1U5R-A nrPDB 100 1e-21 4JG6-A nrPDB 100 1e-21 3H4J-B nrPDB 100 1e-21 4APC-A nrPDB 99 2e-21 2GCD-A nrPDB 99 2e-21 2Y7J-A nrPDB 98 6e-21 6FD3-A nrPDB 98 7e-21 2BDW-A nrPDB 97 1e-20 4I6B-A nrPDB 96 2e-20 5JZN-A nrPDB 96 2e-20 6QAU-A nrPDB 96 2e-20 6CMJ-A nrPDB 96 2e-20 3KK8-A nrPDB 96 3e-20 2BRG-A nrPDB 96 3e-20 2F57-A nrPDB 96 3e-20 3IS5-A nrPDB 95 5e-20 4YZB-A nrPDB 94 7e-20 3Q53-A nrPDB 94 8e-20 3MN3-A nrPDB 94 8e-20 6FDY-U nrPDB 94 1e-19 2VN9-A nrPDB 94 1e-19 3F3Z-A nrPDB 93 1e-19 5XZW-A nrPDB 93 2e-19 2JAM-A nrPDB 93 2e-19 4B6L-A nrPDB 93 2e-19 2VZ6-A nrPDB 92 3e-19 5U6Y-A nrPDB 92 3e-19 3DAK-A nrPDB 92 3e-19 4CZT-A nrPDB 92 5e-19 4EQM-A nrPDB 91 8e-19 4PDS-A nrPDB 91 8e-19 3VN9-A nrPDB 91 8e-19 2WTK-C nrPDB 91 1e-18 5YV8-A nrPDB 90 1e-18 5IG1-A nrPDB 90 1e-18 5WAX-A nrPDB 90 1e-18 4D28-A nrPDB 90 1e-18 4JXF-A nrPDB 90 2e-18 1KOB-A nrPDB 90 2e-18 3SOA-A nrPDB 90 2e-18 1ZXE-A nrPDB 90 2e-18 6CQF-A nrPDB 90 2e-18 3ORZ-A nrPDB 90 2e-18 3FME-A nrPDB 89 2e-18 3GUB-A nrPDB 89 2e-18 5UNP-A nrPDB 89 2e-18 5DBX-A nrPDB 89 3e-18 5D9K-A nrPDB 89 3e-18 4C0T-A nrPDB 89 4e-18 2JC6-A nrPDB 89 4e-18 4UZD-A nrPDB 89 4e-18 3D2K-A nrPDB 88 6e-18 2J90-A nrPDB 88 6e-18 2OU7-A nrPDB 88 6e-18 5ES1-A nrPDB 88 6e-18 2Z7Q-A nrPDB 88 7e-18 4J52-A nrPDB 88 7e-18 4L42-A nrPDB 88 8e-18 3UTO-A nrPDB 88 8e-18 3HDN-A nrPDB 87 9e-18 3KN6-A nrPDB 87 1e-17 4QMW-A nrPDB 87 1e-17 3DB8-A nrPDB 87 1e-17 6GQK-A nrPDB 87 1e-17 1KOA-A nrPDB 87 1e-17 4JDH-A nrPDB 87 1e-17 4X3F-A nrPDB 87 1e-17 3COM-A nrPDB 87 2e-17 4OW8-A nrPDB 87 2e-17 4RLP-A nrPDB 87 2e-17 6B2Q-A nrPDB 86 2e-17 3PPZ-A nrPDB 86 2e-17 2XIK-A nrPDB 86 2e-17 4WNO-A nrPDB 86 2e-17 4FIE-A nrPDB 86 2e-17 5YKS-A nrPDB 86 2e-17 1JPA-A nrPDB 86 3e-17 2W4O-A nrPDB 86 4e-17 2Q0N-A nrPDB 86 4e-17 4KIK-B nrPDB 86 4e-17 4D2V-A nrPDB 85 4e-17 2WQN-A nrPDB 85 4e-17 4KS7-A nrPDB 85 5e-17 4LG4-A nrPDB 85 5e-17 4XBR-A nrPDB 85 6e-17 2XNP-A nrPDB 85 6e-17 4CFH-A nrPDB 85 6e-17 4CQG-A nrPDB 84 7e-17 6AO5-A nrPDB 84 7e-17 3LM0-A nrPDB 84 9e-17 4REW-A nrPDB 84 1e-16 4FZF-B nrPDB 84 1e-16 5MJB-A nrPDB 84 1e-16 6CCF-A nrPDB 84 1e-16 1ZWS-A nrPDB 83 2e-16 4YNZ-A nrPDB 83 2e-16 2A27-A nrPDB 83 2e-16 2H8H-A nrPDB 83 2e-16 2JD5-A nrPDB 82 3e-16 2QNJ-A nrPDB 82 3e-16 2YAB-A nrPDB 82 3e-16 4RED-A nrPDB 82 4e-16 2X4F-A nrPDB 82 4e-16 3UC3-A nrPDB 82 4e-16 4M7I-A nrPDB 82 4e-16 2HK5-A nrPDB 82 5e-16 3QA8-A nrPDB 81 7e-16 1FOT-A nrPDB 81 8e-16 5J5T-A nrPDB 81 9e-16 5L6P-A nrPDB 81 9e-16 6F3F-A nrPDB 81 1e-15 5D7A-A nrPDB 80 1e-15 5SYS-A nrPDB 80 1e-15 2RIO-A nrPDB 80 2e-15 5X5O-A nrPDB 80 2e-15 4B8L-A nrPDB 79 2e-15 3A4O-X nrPDB 79 2e-15 5UIU-A nrPDB 79 3e-15 5H2U-A nrPDB 79 3e-15 5GRN-A nrPDB 79 3e-15 5TQX-A nrPDB 79 3e-15 2DQ7-X nrPDB 79 4e-15 2PL0-A nrPDB 79 4e-15 2W1I-A nrPDB 79 4e-15 3KA0-A nrPDB 79 4e-15 3IO7-A nrPDB 79 4e-15 2X7G-A nrPDB 79 4e-15 6C9D-A nrPDB 79 4e-15 5KZ7-A nrPDB 79 5e-15 2R2P-A nrPDB 79 5e-15 4WUA-A nrPDB 78 6e-15 1BYG-A nrPDB 78 6e-15 1TKI-A nrPDB 78 7e-15 4F9B-A nrPDB 78 8e-15 5N23-A nrPDB 77 8e-15 5X3F-B nrPDB 77 9e-15 2HW6-A nrPDB 77 9e-15 1K9A-A nrPDB 77 1e-14 6BDL-A nrPDB 77 1e-14 6CKI-A nrPDB 77 1e-14 4U41-A nrPDB 77 1e-14 6DBN-A nrPDB 77 1e-14 4P5Q-A nrPDB 77 1e-14 2VWV-A nrPDB 77 1e-14 4CFF-A nrPDB 77 1e-14 4WB7-A nrPDB 77 1e-14 2YZA-A nrPDB 77 1e-14 4GS6-A nrPDB 77 1e-14 4PDO-A nrPDB 77 2e-14 5EZV-A nrPDB 76 2e-14 4UYA-A nrPDB 76 2e-14 2OZA-A nrPDB 76 2e-14 1NY3-A nrPDB 76 2e-14 2HAK-A nrPDB 76 3e-14 3TAC-A nrPDB 76 3e-14 1AD5-A nrPDB 76 3e-14 4FR4-A nrPDB 75 3e-14 5WNO-A nrPDB 75 3e-14 2UV2-A nrPDB 75 3e-14 3DTC-A nrPDB 75 3e-14 4TNB-A nrPDB 75 4e-14 3DKO-A nrPDB 75 4e-14 3CJF-A nrPDB 75 5e-14 3ZUT-A nrPDB 75 5e-14 3UDB-A nrPDB 75 5e-14 3G0E-A nrPDB 75 6e-14 2A1A-B nrPDB 75 6e-14 6CTH-A nrPDB 74 8e-14 2Y6O-A nrPDB 74 8e-14 4UY9-A nrPDB 74 1e-13 6J5U-C nrPDB 74 1e-13 1S9I-A nrPDB 73 2e-13 5DYK-A nrPDB 73 2e-13 6DBM-A nrPDB 73 2e-13 3ALO-A nrPDB 73 3e-13 4IDT-A nrPDB 72 3e-13 5HVK-A nrPDB 72 3e-13 4Y83-A nrPDB 72 4e-13 5VO2-A nrPDB 72 4e-13 5F9E-A nrPDB 72 4e-13 4E93-A nrPDB 72 4e-13 3ORP-A nrPDB 72 5e-13 3DLS-A nrPDB 72 5e-13 4CSV-A nrPDB 71 7e-13 3UIU-A nrPDB 71 8e-13 5FET-A nrPDB 71 9e-13 4AN9-A nrPDB 71 1e-12 1U59-A nrPDB 70 1e-12 4HVI-A nrPDB 70 1e-12 5X02-A nrPDB 70 1e-12 4XUF-A nrPDB 70 1e-12 5LOH-A nrPDB 70 1e-12 2OZO-A nrPDB 70 2e-12 6ED6-A nrPDB 70 2e-12 5KKR-C nrPDB 70 2e-12 3HKO-A nrPDB 70 2e-12 4RA4-A nrPDB 70 2e-12 6BXI-A nrPDB 70 2e-12 3TT0-A nrPDB 70 2e-12 3EQC-A nrPDB 70 2e-12 2PMN-X nrPDB 69 2e-12 4AF3-A nrPDB 69 3e-12 5HI2-A nrPDB 69 3e-12 4G3E-A nrPDB 69 3e-12 3GQL-A nrPDB 69 3e-12 6HV0-A nrPDB 69 4e-12 2I0E-A nrPDB 69 4e-12 4XCU-A nrPDB 69 4e-12 5XD6-A nrPDB 69 5e-12 3VHK-A nrPDB 69 5e-12 6E9W-A nrPDB 68 6e-12 3PFQ-A nrPDB 68 6e-12 4OLI-A nrPDB 68 6e-12 4M66-A nrPDB 68 6e-12 1VZO-A nrPDB 68 7e-12 5UUU-A nrPDB 68 8e-12 5KCV-A nrPDB 68 8e-12 5A46-A nrPDB 68 8e-12 2JDO-A nrPDB 68 8e-12 3PVW-A nrPDB 67 9e-12 3MV5-A nrPDB 67 1e-11 5O0Y-A nrPDB 67 1e-11 3OMV-A nrPDB 67 1e-11 5WNL-A nrPDB 67 1e-11 4PL5-B nrPDB 67 1e-11 3KUL-B nrPDB 67 1e-11 3QGY-A nrPDB 67 1e-11 3A8W-A nrPDB 67 2e-11 3BEA-A nrPDB 67 2e-11 5EG3-A nrPDB 67 2e-11 3PLS-A nrPDB 66 2e-11 3LLT-A nrPDB 66 2e-11 4XI2-A nrPDB 66 2e-11 4C59-A nrPDB 66 3e-11 5TOS-A nrPDB 66 3e-11 6E4F-A nrPDB 65 3e-11 4NEU-A nrPDB 65 3e-11 3KRL-A nrPDB 65 3e-11 6HXF-B nrPDB 65 4e-11 3QD2-B nrPDB 65 4e-11 3C51-A nrPDB 65 4e-11 3NYO-A nrPDB 65 5e-11 2PSQ-A nrPDB 65 5e-11 4E20-A nrPDB 65 6e-11 5O2C-A nrPDB 65 6e-11 2H34-A nrPDB 65 6e-11 5O2B-A nrPDB 65 7e-11 4K33-A nrPDB 65 7e-11 3FXW-A nrPDB 64 7e-11 1U54-B nrPDB 64 7e-11 5HIE-A nrPDB 64 8e-11 5HLW-A nrPDB 64 8e-11 3HNG-A nrPDB 64 8e-11 4PWN-A nrPDB 64 1e-10 5GNK-A nrPDB 64 1e-10 4Y93-A nrPDB 64 1e-10 4HZS-A nrPDB 64 1e-10 3LZB-A nrPDB 64 1e-10 3C1X-A nrPDB 64 1e-10 6NPU-A nrPDB 64 1e-10 3MDY-A nrPDB 64 1e-10 5B2L-A nrPDB 63 2e-10 4XEY-B nrPDB 63 2e-10 5TUR-A nrPDB 63 3e-10 6GVJ-A nrPDB 62 3e-10 3HMP-A nrPDB 62 3e-10 4RT7-A nrPDB 62 3e-10 2XYN-A nrPDB 62 3e-10 2FO0-A nrPDB 62 3e-10 6BSD-A nrPDB 62 4e-10 2OGV-A nrPDB 62 4e-10 6FEX-A nrPDB 62 4e-10 5AP3-A nrPDB 62 5e-10 3BGP-A nrPDB 62 5e-10 4RC3-A nrPDB 62 5e-10 3M42-A nrPDB 62 6e-10 5IKW-A nrPDB 61 6e-10 4XLV-A nrPDB 61 7e-10 5AMN-A nrPDB 61 1e-09 4Y12-A nrPDB 61 1e-09 4FL3-A nrPDB 61 1e-09 4AT3-A nrPDB 61 1e-09 2J0K-A nrPDB 60 1e-09 4OTD-A nrPDB 60 1e-09 2ZMD-A nrPDB 60 1e-09 5C26-A nrPDB 60 1e-09 4CRS-A nrPDB 60 1e-09 2BUJ-A nrPDB 60 1e-09 4R7H-A nrPDB 60 1e-09 1FVR-A nrPDB 60 2e-09 5J0A-A nrPDB 60 2e-09 2PZI-A nrPDB 60 2e-09 4TPT-A nrPDB 60 2e-09 4LRM-A nrPDB 60 2e-09 3SOC-A nrPDB 60 2e-09 6BFN-A nrPDB 59 3e-09 2QLU-A nrPDB 59 3e-09 4YFF-A nrPDB 59 3e-09 3TXO-A nrPDB 59 3e-09 3BBT-B nrPDB 59 3e-09 4YHJ-A nrPDB 59 4e-09 4EBW-A nrPDB 59 5e-09 1PY5-A nrPDB 59 5e-09 3PP0-A nrPDB 58 5e-09 5TE0-A nrPDB 58 6e-09 6FER-A nrPDB 58 7e-09 4X7Q-B nrPDB 57 1e-08 5FM2-A nrPDB 57 1e-08 3MY0-A nrPDB 57 1e-08 3V5Q-A nrPDB 57 2e-08 5KMM-A nrPDB 57 2e-08 5U6B-A nrPDB 56 2e-08 5LPZ-A nrPDB 56 2e-08 3Q4U-A nrPDB 56 2e-08 5AR8-A nrPDB 56 2e-08 5LPV-A nrPDB 56 3e-08 2QKW-B nrPDB 56 3e-08 3I81-A nrPDB 56 3e-08 3TKU-A nrPDB 56 3e-08 3ZZW-A nrPDB 55 4e-08 4AW2-A nrPDB 55 4e-08 3SXS-A nrPDB 55 4e-08 4H1J-A nrPDB 55 6e-08 3UIM-A nrPDB 54 1e-07 5E8V-A nrPDB 54 2e-07 1LUF-A nrPDB 53 2e-07 3G2F-A nrPDB 53 2e-07 3LMG-A nrPDB 53 2e-07 5VD3-A nrPDB 53 3e-07 5L2Q-C nrPDB 53 3e-07 4F0G-A nrPDB 52 3e-07 5X1R-A nrPDB 50 1e-06 4EUU-A nrPDB 50 2e-06 4NFN-A nrPDB 50 2e-06 3QUP-A nrPDB 50 2e-06 4LQP-A nrPDB 50 2e-06 4BTK-A nrPDB 50 2e-06 4EUT-A nrPDB 49 3e-06 5U6C-A nrPDB 49 3e-06 5FQD-C nrPDB 49 3e-06 4JLC-A nrPDB 49 3e-06 6NT9-A nrPDB 48 7e-06 6O8B-A nrPDB 48 9e-06 2Y4I-B nrPDB 47 1e-05 4L68-A nrPDB 47 2e-05 4TN6-A nrPDB 46 3e-05 5VC6-A nrPDB 45 3e-05 2WTK-B nrPDB 45 4e-05 2VD5-A nrPDB 45 4e-05 3SV0-A nrPDB 45 6e-05 2LAV-A nrPDB 44 9e-05 5CEK-A nrPDB 44 1e-04 2CMW-A nrPDB 44 1e-04 2RSV-A nrPDB 44 1e-04 4NT4-A nrPDB 44 1e-04 5OAT-A nrPDB 44 1e-04 6DC0-A nrPDB 43 2e-04 1CSN-A nrPDB 42 5e-04 2CHL-A nrPDB 42 5e-04 4JRN-A nrPDB 40 0.002 5X18-A nrPDB 39 0.003 4M69-B nrPDB 39 0.004 4IX6-A nrPDB 38 0.008 5VDK-A nrPDB 38 0.008 2C47-A nrPDB 38 0.009 4BTF-A nrPDB 38 0.009 3ENH-A nrPDB 38 0.009 5M07-A nrPDB 37 0.014 4XHL-A nrPDB 36 0.025 5CLR-A nrPDB 36 0.031 4XHH-A nrPDB 36 0.034 4L00-A nrPDB 35 0.042 5UU1-A nrPDB 34 0.12 5VE6-A nrPDB 33 0.15 6EWX-A nrPDB 33 0.15 2XHY-A nrPDB 33 0.20 4CI6-B nrPDB 33 0.25 6EQI-C nrPDB 32 0.35 4OAU-C nrPDB 32 0.39 6J6I-B nrPDB 32 0.63 5USZ-A nrPDB 31 0.85 2R1H-A nrPDB 31 1.1 4O1O-A nrPDB 29 2.8 5DMZ-A nrPDB 29 3.8 3BCQ-A nrPDB 28 4.6 5LC5-m nrPDB 28 6.0 6BHC-A nrPDB 28 9.5 3K57-A nrPDB 28 9.6 >4QTB-A nrPDB Length = 380 Score = 791 bits (2042), Expect = 0.0, Method: Compositional matrix adjust. Identities = 379/379 (100%), Positives = 379/379 (100%) Query: 1 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY Sbjct: 2 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 61 Query: 61 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI Sbjct: 62 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 121 Query: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 180 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL Sbjct: 122 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 181 Query: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS Sbjct: 182 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 241 Query: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD Sbjct: 242 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 301 Query: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL 360 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL Sbjct: 302 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL 361 Query: 361 KELIFQETARFQPGVLEAP 379 KELIFQETARFQPGVLEAP Sbjct: 362 KELIFQETARFQPGVLEAP 380 >5NGU-A nrPDB Length = 381 Score = 650 bits (1676), Expect = 0.0, Method: Compositional matrix adjust. Identities = 304/346 (87%), Positives = 326/346 (94%) Query: 29 EMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLRE 88 EMV+GQ FDVGPRYT L YIGEGAYGMV SAYD++ K RVAIKKISPFEHQTYCQRTLRE Sbjct: 31 EMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLRE 90 Query: 89 IQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148 I+ILLRFRHEN+IGI DI+RA T+E M+DVYIVQDLMETDLYKLLK+Q LSNDHICYFLY Sbjct: 91 IKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 150 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 QILRGLKYIHSANVLHRDLKPSNLL+NTTCDLKICDFGLAR+ADP+HDHTGFLTEYVATR Sbjct: 151 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 210 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED Sbjct: 211 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 270 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 328 LNCIIN+KARNYL SLP K KV W +LFP +DSKALDLLD+MLTFNP+KRI VE+ALAHP Sbjct: 271 LNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 330 Query: 329 YLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPG 374 YLEQYYDP+DEP+AE PF F MELDDLPKE+LKELIF+ETARFQPG Sbjct: 331 YLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPG 376 >4IC8-A nrPDB Length = 442 Score = 352 bits (904), Expect = 1e-97, Method: Compositional matrix adjust. Identities = 174/341 (51%), Positives = 238/341 (69%), Gaps = 4/341 (1%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLR 94 FDVG Y ++ IG GAYG+VSSA + +VAIKKI + F+ T +RTLRE++IL Sbjct: 51 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 110 Query: 95 FRHENVIGIRDILRAST-LEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILR 152 F+H+N+I I+DILR + + VY+V DLME+DL++++ S Q L+ +H+ YFLYQ+LR Sbjct: 111 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 170 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYR 211 GLKY+HSA V+HRDLKPSNLL+N C+LKI DFG+AR + +H F+TEYVATRWYR Sbjct: 171 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 230 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 APE+ML+ YT++ID+WSVGCI EML+ R +FPGK+Y+ QL I+ +LG+PS + Sbjct: 231 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 290 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + + R Y+QSLP + V W ++P +D +AL LL RML F P+ RI+ AL HP+L Sbjct: 291 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 350 Query: 332 QYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQ 372 +Y+DP DEP PF FA + + L +ER+KE I E F Sbjct: 351 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFH 391 >4ZSG-A nrPDB Length = 347 Score = 352 bits (902), Expect = 2e-97, Method: Compositional matrix adjust. Identities = 174/341 (51%), Positives = 238/341 (69%), Gaps = 4/341 (1%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLR 94 FDVG Y ++ IG GAYG+VSSA + +VAIKKI + F+ T +RTLRE++IL Sbjct: 3 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 62 Query: 95 FRHENVIGIRDILRAST-LEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILR 152 F+H+N+I I+DILR + + VY+V DLME+DL++++ S Q L+ +H+ YFLYQ+LR Sbjct: 63 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 122 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYR 211 GLKY+HSA V+HRDLKPSNLL+N C+LKI DFG+AR + +H F+TEYVATRWYR Sbjct: 123 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 182 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 APE+ML+ YT++ID+WSVGCI EML+ R +FPGK+Y+ QL I+ +LG+PS + Sbjct: 183 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 242 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + + R Y+QSLP + V W ++P +D +AL LL RML F P+ RI+ AL HP+L Sbjct: 243 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 302 Query: 332 QYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQ 372 +Y+DP DEP PF FA + + L +ER+KE I E F Sbjct: 303 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFH 343 >2F9G-A nrPDB Length = 353 Score = 349 bits (895), Expect = 1e-96, Method: Compositional matrix adjust. Identities = 177/351 (50%), Positives = 235/351 (66%), Gaps = 14/351 (3%) Query: 30 MVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREI 89 M K +++ + +GEGAYG+V SA VAIKKI PF+ + RTLREI Sbjct: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 Query: 90 QILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQ 149 +IL F+HEN+I I +I R + E +VYI+Q+LM+TDL++++ +Q LS+DHI YF+YQ Sbjct: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIAD--------PEHDHTGFL 201 LR +K +H +NV+HRDLKPSNLLIN+ CDLK+CDFGLARI D P +G + Sbjct: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG-M 179 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 261 TEYVATRWYRAPE+ML S Y++++D+WS GCILAE+ RPIFPG+ Y QL I GI+ Sbjct: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 Query: 262 GSP-SQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT 320 G+P S DL CI + +AR Y++SLP K+FP+ + K +DLL RML F+P KRIT Sbjct: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 Query: 321 VEEALAHPYLEQYYDPTDEPVAE----EPFTFAMELDDLPKERLKELIFQE 367 +EAL HPYL+ Y+DP DEP E F F + L + LK+LI+ E Sbjct: 300 AKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNE 350 >6DTL-A nrPDB Length = 364 Score = 334 bits (857), Expect = 3e-92, Method: Compositional matrix adjust. Identities = 172/346 (49%), Positives = 239/346 (69%), Gaps = 8/346 (2%) Query: 31 VKGQPFDVGPRYTQ-LQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLRE 88 + G F+V +Y + IG+GAYG+V SA + VAIKKI+ F+++ +RTLRE Sbjct: 20 IFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLRE 79 Query: 89 IQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFL 147 I++L HEN++ IRDI+ A DVYI +LM+TDL+++++S Q LS +H YFL Sbjct: 80 IKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFL 139 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 YQILRGLKYIHSANVLHRDLKPSNLL+N CDLKICDFGLAR+ + F+TEYV T Sbjct: 140 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVT----SESDFMTEYVVT 195 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 RWYRAPE++LNS YT +ID+WSVGCI E++ +P+FPG+ ++ QL ++ ++G+PS+E Sbjct: 196 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 255 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAH 327 +L +N A+ Y++ LP + + FP A+DL+++MLTF+P +RITV +ALAH Sbjct: 256 ELE-FLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAH 314 Query: 328 PYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 373 PYL +D +DEP PF F E L +E++KELI++E F P Sbjct: 315 PYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNP 360 >4EWQ-A nrPDB Length = 383 Score = 332 bits (851), Expect = 2e-91, Method: Compositional matrix adjust. Identities = 169/344 (49%), Positives = 233/344 (67%), Gaps = 9/344 (2%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94 ++V RY L +G GAYG V +A+D RVA+KK+S PF+ + +RT RE+++L Sbjct: 41 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 100 Query: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 +HENVIG+ D+ A +LE DVY+V LM DL ++K Q+L++DH+ + +YQILRG Sbjct: 101 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 160 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 LKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVATRWYRAP Sbjct: 161 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 214 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 EIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I Sbjct: 215 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 274 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 + ARNY+QSL K+ +A +F ++ A+DLL++ML + +KRIT +ALAH Y QY Sbjct: 275 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 334 Query: 334 YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLE 377 +DP DEPVA +P+ + E DL + K L + E F P L+ Sbjct: 335 HDPDDEPVA-DPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLD 377 >5Z33-A nrPDB Length = 425 Score = 329 bits (844), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 175/354 (49%), Positives = 242/354 (68%), Gaps = 8/354 (2%) Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP-FEHQTYCQRTLREI 89 V Q F V RYT + +G+GAYG+V +A ++ VAIKK++ F + +R LREI Sbjct: 22 VFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREI 81 Query: 90 QILLRFR-HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFL 147 ++L FR H N+ + D + + + Y+ ++LME DL +++S Q L++ H F+ Sbjct: 82 KLLQHFRGHRNITCLYD-MDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFI 140 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR--IADPEHDHTGFLTEYV 205 YQIL GLKYIHSANVLHRDLKP NLL+N C+LKICDFGLAR DPE ++ G++TEYV Sbjct: 141 YQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPE-ENAGYMTEYV 199 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 ATRWYRAPEIML+ + YTK+ID+WSVGCILAE+L RP F G+ Y+DQLN IL ILG+P+ Sbjct: 200 ATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPN 259 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 +E L+ I + +A+ Y+++LP K + LFP ++ ALDLLDRML F+P+ RI+VE+AL Sbjct: 260 EETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQAL 319 Query: 326 AHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP 379 HPYL ++D +DEP F F E+ + E ++++I E RF+ V AP Sbjct: 320 EHPYLHIWHDASDEPDCPTTFNFDFEVVEDVGE-MRKMILDEVYRFRQLVRTAP 372 >3OHT-A nrPDB Length = 389 Score = 325 bits (834), Expect = 2e-89, Method: Compositional matrix adjust. Identities = 162/339 (47%), Positives = 230/339 (67%), Gaps = 9/339 (2%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94 ++V RY L +G GAYG V S+YD ++A+KK+S PF+ + +RT RE+++L Sbjct: 47 WEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKH 106 Query: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 +HENVIG+ D+ A++LE DVY+V LM DL ++K Q+L++DH+ + +YQILRG Sbjct: 107 MKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 166 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 LKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVATRWYRAP Sbjct: 167 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 220 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 EIMLN Y ++DIWSVGCI+AE+L+ R +FPG +++QL I+ + G+P ++ + Sbjct: 221 EIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMP 280 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 + +ARNY+ SLP K +A +F ++ A+DLL++ML + +KRIT EALAHPY QY Sbjct: 281 SHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQY 340 Query: 334 YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQ 372 +DP DEP + EP+ + E L E K L ++E F+ Sbjct: 341 HDPDDEPES-EPYDQSFESRQLEIEEWKRLTYEEVCSFE 378 >3GC9-A nrPDB Length = 370 Score = 322 bits (824), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 161/338 (47%), Positives = 229/338 (67%), Gaps = 9/338 (2%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94 ++V R L+ +G GAYG V SAYD + +VA+KK+S PF+ + +RT RE+++L Sbjct: 24 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 83 Query: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 +HENVIG+ D+ A+++E +VY+V LM DL ++KSQ LS++H+ + +YQ+LRG Sbjct: 84 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQALSDEHVQFLVYQLLRG 143 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 LKYIHSA ++HRDLKPSN+ +N +L+I DFGLAR AD E +T YVATRWYRAP Sbjct: 144 LKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEE------MTGYVATRWYRAP 197 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 EIMLN Y +++DIWSVGCI+AE+L + +FPG Y+DQL I+ ++G+PS E L I Sbjct: 198 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 257 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 + AR Y+QSLP + + +F ++ A+DLL RML + ++R++ EALAH Y QY Sbjct: 258 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 317 Query: 334 YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARF 371 +DP DEP A EP+ ++E + E KEL +QE F Sbjct: 318 HDPEDEPEA-EPYDESVEAKERTLEEWKELTYQEVLSF 354 >4MYG-A nrPDB Length = 372 Score = 305 bits (782), Expect = 2e-83, Method: Compositional matrix adjust. Identities = 152/345 (44%), Positives = 223/345 (64%), Gaps = 9/345 (2%) Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89 V +++ Y ++G GAYG V SA D +VAIKK+S PF+ + + +R RE+ Sbjct: 34 VNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL 93 Query: 90 QILLRFRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148 +L +HENVIG+ D+ AS+L D Y+V M+TDL K++ + S + I Y +Y Sbjct: 94 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-GMEFSEEKIQYLVY 152 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 Q+L+GLKYIHSA V+HRDLKP NL +N C+LKI DFGLAR AD E +T YV TR Sbjct: 153 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTR 206 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 WYRAPE++L+ Y +++DIWSVGCI+AEML+ + +F GK YLDQL IL + G P E Sbjct: 207 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 266 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 328 + + + A++Y+QSLP + + +LFP++ +A DLL++ML + +KR+T +AL HP Sbjct: 267 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 326 Query: 329 YLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 373 + E + DP +E A++PF ++E + L + K+ I++E F P Sbjct: 327 FFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 371 >4QNY-A nrPDB Length = 354 Score = 295 bits (755), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 146/336 (43%), Positives = 220/336 (65%), Gaps = 8/336 (2%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTR-VAIKKISP--FEHQTYCQRTLREIQILLRFRH 97 RY + IG G+YG+V A D R VA+K+++ FE +R LREI++L F Sbjct: 21 RYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFND 80 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS-QQLSNDHICYFLYQILRGLKY 156 +N+IG+R+IL E YIV D+METDL ++L+S Q+L+ HI +F+YQ LR L Sbjct: 81 DNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQFFIYQALRALHI 140 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 IHSA V+HRD+ P+N+L+NT CDLKICDFGLA+ E+D ++T+YV RWYRAPE++ Sbjct: 141 IHSAGVIHRDITPANILVNTNCDLKICDFGLAK---EENDQGEYMTDYVTMRWYRAPELV 197 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + K Y+ ID+W +GCIL E+L +RP+F GK ++QL+ I+ ++G+PS+ED+N + + Sbjct: 198 MEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSA 257 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 A+ YL+ + + W + +P + +ALDLL ML FNP +RITV +A+ HP+LEQ +D Sbjct: 258 AQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHDD 317 Query: 337 TDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQ 372 D+ ++ F F E + +K I++E+ +F Sbjct: 318 ADDNLSYALFRFD-ENEQKTIVDVKRAIYEESVKFH 352 >1CM8-A nrPDB Length = 367 Score = 292 bits (747), Expect = 2e-79, Method: Compositional matrix adjust. Identities = 147/347 (42%), Positives = 219/347 (63%), Gaps = 13/347 (3%) Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREI 89 V ++V Y LQ +G GAYG V SA D +VAIKK+ PF+ + + +R RE+ Sbjct: 16 VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75 Query: 90 QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148 ++L RHENVIG+ D+ TL+ D Y+V M TDL KL+K ++L D I + +Y Sbjct: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVY 135 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 Q+L+GL+YIH+A ++HRDLKP NL +N C+LKI DFGLAR AD E +T YV TR Sbjct: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE------MTGYVVTR 189 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 WYRAPE++LN YT+++DIWSVGCI+AEM++ + +F G +LDQL I+ + G+P E Sbjct: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 328 + + + +A+NY++ LP K +A + + A++LL++ML + +R+T EALAHP Sbjct: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHP 309 Query: 329 YLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQETARFQP 373 Y E +D DEP ++ + DD+ + + K + ++E F+P Sbjct: 310 YFESLHDTEDEPQVQK---YDDSFDDVDRTLDEWKRVTYKEVLSFKP 353 >1JNK-A nrPDB Length = 423 Score = 266 bits (680), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 148/355 (41%), Positives = 224/355 (63%), Gaps = 26/355 (7%) Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89 V F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ Sbjct: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 Query: 90 QILLRFRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148 ++ H+N+I + ++ TLE +DVY+V +LM+ +L ++++ +L ++ + Y LY Sbjct: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLY 171 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGF-LTEYVAT 207 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A T F +T YV T Sbjct: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-----TSFMMTPYVVT 226 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 R+YRAPE++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E Sbjct: 227 RYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNP 315 + + RNY+++ P + + KLFP S S+A DLL +ML +P Sbjct: 286 FMK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 Query: 316 NKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQET 368 KRI+V++AL HPY+ +YDP E A P + +LD+ E KELI++E Sbjct: 345 AKRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 >3OZ6-A nrPDB Length = 388 Score = 266 bits (679), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 147/369 (39%), Positives = 224/369 (60%), Gaps = 44/369 (11%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFR-HE 98 +Y ++ +G+GAYG+V + D VA+KKI F++ T QRT REI IL HE Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHE 69 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 N++ + ++LRA + RDVY+V D METDL+ ++++ L H Y +YQ+++ +KY+H Sbjct: 70 NIVNLLNVLRA---DNDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKVIKYLH 126 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLAR-------------IADPEH-----DHTGF 200 S +LHRD+KPSN+L+N C +K+ DFGL+R ++ E+ D Sbjct: 127 SGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPI 186 Query: 201 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI 260 LT+YVATRWYRAPEI+L S YTK ID+WS+GCIL E+L +PIFPG ++QL I+G+ Sbjct: 187 LTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERIIGV 246 Query: 261 LGSPSQEDLNCIINMKARNYLQSLPSKTKV----------AWAKLF----PKSD--SKAL 304 + PS ED+ I + A+ ++SL K ++ W L PK+D +AL Sbjct: 247 IDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEEAL 306 Query: 305 DLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL---K 361 DLLD++L FNPNKRI+ +AL HP++ +++P +EP + T + ++D K + + Sbjct: 307 DLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIIT--IPINDNVKHSIDDYR 364 Query: 362 ELIFQETAR 370 L++ E +R Sbjct: 365 NLVYSEISR 373 >4O2Z-A nrPDB Length = 377 Score = 265 bits (676), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 146/360 (40%), Positives = 215/360 (59%), Gaps = 15/360 (4%) Query: 22 PGVPGEVEM--VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEH 78 P + G+ ++ V G PF+V +YT L+ +G GAYG+ S D +V+IKK F Sbjct: 25 PKIVGDFKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRD 84 Query: 79 QTYCQRTLREIQILLRFRHENVIGIRDILRASTLE--AMRDVYIVQDLMETDLYKLLKSQ 136 +R LREI ++ F HEN++ + +IL E + DVY+V LM+ D+ +L+S+ Sbjct: 85 VEDGKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSR 144 Query: 137 Q-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH 195 Q L H+ YF+YQILRGLKY+HSANV HRDLKP+NL+ N +C+LKI DFGL+R D + Sbjct: 145 QVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPY 204 Query: 196 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLN 255 LT+YV TRWYR PE++L + Y+ ++DIWSVGCI AEM + +P+FPG++ +DQL Sbjct: 205 SE---LTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLR 261 Query: 256 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFP--KSDSKALDLLDRMLTF 313 I +G P + + + +A L LP + + KL P +++ +D L +M T Sbjct: 262 MIAQHIGKPPA---SIVEHREALEKLNELPDGS-LNIPKLVPGLAGNTEGIDFLSKMWTL 317 Query: 314 NPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 373 +P+KR T + LAHPYL +D DEP PF +A E + L+ + + + P Sbjct: 318 DPSKRPTAADMLAHPYLAHLHDEEDEPTCPCPFLWAHESTPMGVSELRRAFWADIVDYNP 377 >2I6L-A nrPDB Length = 320 Score = 264 bits (674), Expect = 5e-71, Method: Compositional matrix adjust. Identities = 146/319 (45%), Positives = 202/319 (63%), Gaps = 18/319 (5%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95 FD+G RY L+ +G G G+V SA D+ RVAIKKI + Q+ + LREI+I+ R Sbjct: 7 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQS-VKHALREIKIIRRL 65 Query: 96 RHENVIGIRDILRAS---------TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYF 146 H+N++ + +IL S +L + VYIVQ+ METDL +L+ L +H F Sbjct: 66 DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLF 125 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTT-CDLKICDFGLARIADPEHDHTGFLTEYV 205 +YQ+LRGLKYIHSANVLHRDLKP+NL INT LKI DFGLARI DP + H G L+E + Sbjct: 126 MYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGL 185 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 T+WYR+P ++L+ YTK+ID+W+ GCI AEML+ + +F G H L+Q+ IL + Sbjct: 186 VTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVH 245 Query: 266 QED---LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVE 322 +ED L +I + RN + P K +L P +A+D L+++LTF+P R+T E Sbjct: 246 EEDRQELLSVIPVYIRNDMTE-PHK---PLTQLLPGISREAVDFLEQILTFSPMDRLTAE 301 Query: 323 EALAHPYLEQYYDPTDEPV 341 EAL+HPY+ Y P DEP+ Sbjct: 302 EALSHPYMSIYSFPMDEPI 320 >3E7O-A nrPDB Length = 360 Score = 263 bits (671), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 146/355 (41%), Positives = 223/355 (62%), Gaps = 26/355 (7%) Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89 V F V RY QL+ IG GA G+V +A+D V VA+KK+S PF++QT+ +R RE+ Sbjct: 13 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 72 Query: 90 QILLRFRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148 +L H+N+I + ++ TLE +DVY+V +LM+ +L +++ +L ++ + Y LY Sbjct: 73 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERMSYLLY 131 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGF-LTEYVAT 207 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A T F +T YV T Sbjct: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAS-----TNFMMTPYVVT 186 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 R+YRAPE++L GY +++DIWSVGCI+ E++ IF G ++DQ N ++ LG+PS E Sbjct: 187 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAE 245 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNP 315 + + RNY+++ P+ +A+ +LFP S+A DLL +ML +P Sbjct: 246 FMAA-LQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 304 Query: 316 NKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQET 368 +KRI+V+EAL HPY+ +YDP E A P + +L++ E KELI++E Sbjct: 305 DKRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 358 >5AWM-A nrPDB Length = 394 Score = 259 bits (661), Expect = 2e-69, Method: Compositional matrix adjust. Identities = 141/354 (39%), Positives = 220/354 (62%), Gaps = 25/354 (7%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94 F + RY L+ IG GA G+V +AYD + + VAIKK+S PF++ T+ +R RE +++ Sbjct: 40 FTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 99 Query: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 H+N+IG+ + LE +DVY+V +LM+ +L ++++ L +D + Y LYQ+L G Sbjct: 100 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ-MDLDHDRMSYLLYQMLCG 158 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 +K++HSA ++HRDLKPSN+++ C LKI DFGLAR A T +T YV TR+YRAP Sbjct: 159 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT----TFMMTPYVVTRYYRAP 214 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 E++L GYT+++DIWSVGCI+ EM+ +FPG ++DQ N I+ LG+PS + + Sbjct: 215 EVIL-GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQR-L 272 Query: 274 NMKARNYLQSLPSKTKVAWAKLFP-------------KSDSKALDLLDRMLTFNPNKRIT 320 RNY+++ P T ++ +LFP + S A +LL +ML +P +RI+ Sbjct: 273 QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 332 Query: 321 VEEALAHPYLEQYYDP--TDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQ 372 V+EAL H Y+ +YD D P A EP+ +++ + E+ KELI++E ++ Sbjct: 333 VDEALKHEYINVWYDAEEVDAP-APEPYDHSVDEREHTVEQWKELIYEEVMDYE 385 >3RP9-A nrPDB Length = 458 Score = 257 bits (656), Expect = 7e-69, Method: Compositional matrix adjust. Identities = 150/401 (37%), Positives = 215/401 (53%), Gaps = 64/401 (15%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLR 94 + + RY IG G+YG V AYD + K VAIKKI FE C+R LREI IL R Sbjct: 49 WQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNR 108 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ-QLSNDHICYFLYQILRG 153 H++V+ + DI+ +E ++Y+V ++ ++D KL ++ L+ HI LY +L G Sbjct: 109 LNHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLLVG 168 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIAD-PEHDHTGF------------ 200 +KY+HSA +LHRDLKP+N L+N C +K+CDFGLAR D PE+ ++ Sbjct: 169 VKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLV 228 Query: 201 -----------LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS--------- 240 LT +V TRWYRAPE++L + YT++ID+WS+GCI AE+L+ Sbjct: 229 TFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYH 288 Query: 241 --NRPIFPGKHYL--------------------DQLNHILGILGSPSQEDLNCIINMKAR 278 P+FPG DQLN I ILG+PS+ED+ + A+ Sbjct: 289 ADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAK 348 Query: 279 NYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTD 338 Y++ P + A+ FP S + A+ LL RML FNPNKRIT+ E LAHP+ ++ Sbjct: 349 RYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRIAEV 408 Query: 339 EPVAEE----PFTFAMELDDLPKERLKELIFQETARFQPGV 375 E A E PF M +D+ +L+ +E R+ P + Sbjct: 409 ETNATEKVRLPFNDWMNMDE---PQLRYAFVKEIQRYHPEI 446 >2XS0-A nrPDB Length = 386 Score = 254 bits (650), Expect = 4e-68, Method: Compositional matrix adjust. Identities = 142/350 (40%), Positives = 219/350 (62%), Gaps = 26/350 (7%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94 F V RY L+ IG GA G+V +AYD + + VAIKK+S PF++QT+ +R RE+ ++ Sbjct: 22 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 81 Query: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 H+N+IG+ ++ +LE +DVYIV +LM+ +L ++++ +L ++ + Y LYQ+L G Sbjct: 82 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 140 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGF-LTEYVATRWYRA 212 +K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A T F + +V TR+YRA Sbjct: 141 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-----TSFMMVPFVVTRYYRA 195 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++L GY +++DIWSVGCI+ EM+ +FPG ++DQ N ++ LG+P E + Sbjct: 196 PEVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-K 253 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPNKRIT 320 + R Y+++ P ++ KLFP S+A DLL +ML + +KRI+ Sbjct: 254 LQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS 313 Query: 321 VEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQET 368 V+EAL HPY+ +YDP+ E A P +LD+ E KELI++E Sbjct: 314 VDEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 362 >3FI2-A nrPDB Length = 353 Score = 253 bits (646), Expect = 9e-68, Method: Compositional matrix adjust. Identities = 135/319 (42%), Positives = 206/319 (64%), Gaps = 23/319 (7%) Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89 V F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ Sbjct: 15 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 74 Query: 90 QILLRFRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148 ++ H+N+I + ++ TLE +DVY+V +LM+ +L ++++ +L ++ + Y LY Sbjct: 75 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLY 133 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGF-LTEYVAT 207 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A T F +T YV T Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-----TSFMMTPYVVT 188 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 R+YRAPE++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E Sbjct: 189 RYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 247 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNP 315 + + RNY+++ P + + KLFP S S+A DLL +ML +P Sbjct: 248 FMK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 306 Query: 316 NKRITVEEALAHPYLEQYY 334 KRI+V++AL HPY+ +Y Sbjct: 307 AKRISVDDALQHPYINVWY 325 >3PG1-A nrPDB Length = 362 Score = 248 bits (633), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 129/312 (41%), Positives = 186/312 (59%), Gaps = 22/312 (7%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI----------SPFEHQTYCQRTLREIQI 91 YT ++I G+YG V + D VAIK++ + C+R LREI++ Sbjct: 24 YTVQRFISSGSYGAVCAGVDS-EGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQL--SNDHICYFLYQ 149 L F H N++G+RDI AM +Y+V +LM TDL +++ Q++ S HI YF+Y Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMYH 142 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR--IADPEHDHTGFLTEYVAT 207 IL GL +H A V+HRDL P N+L+ D+ ICDF LAR AD H YV Sbjct: 143 ILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTH------YVTH 196 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 RWYRAPE+++ KG+TK +D+WS GC++AEM + + +F G + +QLN I+ ++G+P E Sbjct: 197 RWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIE 256 Query: 268 DLNCIINMKARNYLQ-SLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 D+ + AR+YL+ SL + AW + P +D ALDL+ +ML FNP +RI+ E+AL Sbjct: 257 DVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALR 316 Query: 327 HPYLEQYYDPTD 338 HPY E +DP D Sbjct: 317 HPYFESLFDPLD 328 >3N9X-A nrPDB Length = 432 Score = 232 bits (592), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 141/391 (36%), Positives = 207/391 (52%), Gaps = 54/391 (13%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP-FEHQTYCQRTLREIQILLRFR 96 V Y IG G+YG V AYD + VAIKK++ FE C+R LREI IL R + Sbjct: 24 VPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLK 83 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGLK 155 + +I + D++ L ++YIV ++ ++DL KL K+ L+ +HI LY +L G Sbjct: 84 SDYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIFLTEEHIKTILYNLLLGEN 143 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGF--------------- 200 +IH + ++HRDLKP+N L+N C +K+CDFGLAR + E D Sbjct: 144 FIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKN 203 Query: 201 ----LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML----------SNR-PIF 245 LT +V TRWYRAPE++L + YTKSIDIWS GCI AE+L +NR P+F Sbjct: 204 LKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLF 263 Query: 246 PG-----------------KHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKT 288 PG K DQLN I I+G+P+++DL I + Y++ P + Sbjct: 264 PGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHRK 323 Query: 289 KVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTF 348 + + +P ++LL+ ML FNPNKRIT+++AL HPYL+ E + + Sbjct: 324 PINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRKKKLENFSTK--KI 381 Query: 349 AMELDD---LPKERLKELIFQETARFQPGVL 376 + DD L + +L+ + +E F P ++ Sbjct: 382 ILPFDDWMVLSETQLRYIFLKEVQSFHPELV 412 >3NIE-A nrPDB Length = 429 Score = 231 bits (589), Expect = 4e-61, Method: Compositional matrix adjust. Identities = 141/394 (35%), Positives = 206/394 (52%), Gaps = 57/394 (14%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP-FEHQTYCQRTLREIQILLRFR 96 V Y IG G+YG V AYD VAIKK++ FE C+R LREI IL R + Sbjct: 26 VPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLK 85 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGLK 155 + +I + D++ L ++YIV ++ ++DL KL K+ L+ H+ LY +L G K Sbjct: 86 SDYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIFLTEQHVKTILYNLLLGEK 145 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD------------------H 197 +IH + ++HRDLKP+N L+N C +KICDFGLAR + + D H Sbjct: 146 FIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPH 205 Query: 198 TGFL----TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML----------SNR- 242 L T +V TRWYRAPE++L + YT SIDIWS GCI AE+L +NR Sbjct: 206 NKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRF 265 Query: 243 PIFPG-----------------KHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLP 285 P+FPG K DQLN I ++G+P +EDL CI + Y++ P Sbjct: 266 PLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFP 325 Query: 286 SKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEP 345 ++ + +K + + +DLL+ ML FN KRIT+++AL+HPYL+ E + E Sbjct: 326 TRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKENLENFSTE- 384 Query: 346 FTFAMELDD---LPKERLKELIFQETARFQPGVL 376 + DD L + +L+ + +E F ++ Sbjct: 385 -KIILPFDDWMVLSETQLRYIFLKEIQSFHADLI 417 >2BPM-A nrPDB Length = 309 Score = 201 bits (512), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 115/309 (37%), Positives = 171/309 (55%), Gaps = 16/309 (5%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENV 100 + +++ IGEG YG+V A + + VA+KKI E + +REI +L H N+ Sbjct: 9 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 68 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSN---DHICYFLYQILRGLKYI 157 + + D++ +Y+V + + DL K + + L+ I +L+Q+L+GL + Sbjct: 69 VKLLDVIHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 123 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIM 216 HS VLHRDLKP NLLINT +K+ DFGLAR P +T V T WYRAPEI+ Sbjct: 124 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT----HEVVTLWYRAPEIL 179 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 L K Y+ ++DIWS+GCI AEM++ R +FPG +DQL I LG+P + + +M Sbjct: 180 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 239 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 +Y S P + ++K+ P D LL +ML ++PNKRI+ + ALAHP+ + P Sbjct: 240 --DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 297 Query: 337 TDEPVAEEP 345 E P Sbjct: 298 VPHLRLERP 306 >3NIZ-A nrPDB Length = 311 Score = 201 bits (512), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 115/298 (38%), Positives = 172/298 (57%), Gaps = 21/298 (7%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHEN 99 +Y +L+ +GEG YG+V A D + VA+K+I E + +REI +L H N Sbjct: 22 KYQKLEKVGEGTYGVVYKAKDSQGRI-VALKRIRLDAEDEGIPSTAIREISLLKELHHPN 80 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ--LSNDHICYFLYQILRGLKYI 157 ++ + D++ + R + +V + ME DL K+L + L + I +LYQ+LRG+ + Sbjct: 81 IVSLIDVIHSE-----RCLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHC 135 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIM 216 H +LHRDLKP NLLIN+ LK+ DFGLAR P +T V T WYRAP+++ Sbjct: 136 HQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYT----HEVVTLWYRAPDVL 191 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM- 275 + SK Y+ S+DIWS+GCI AEM++ +P+FPG DQL I ILG+P+ + + + Sbjct: 192 MGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELP 251 Query: 276 --KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 K R + Q K W+ + P + +DLL ML F+PNKRI+ +A+ HPY + Sbjct: 252 LWKQRTF-QVFEKK---PWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFK 305 >1V0B-A nrPDB Length = 288 Score = 193 bits (490), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 113/296 (38%), Positives = 166/296 (56%), Gaps = 16/296 (5%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHEN 99 +Y L+ IGEG YG+V A ++ +T A+KKI E + T+REI IL +H N Sbjct: 3 KYHGLEKIGEGTYGVVYKAQNNYGET-FALKKIRLEKEDEGIPSTTIREISILKELKHSN 61 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHIC--YFLYQILRGLKYI 157 ++ + D++ + + +V + ++ DL KLL + + + FL Q+L G+ Y Sbjct: 62 IVKLYDVIHTK-----KRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYC 116 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIM 216 H VLHRDLKP NLLIN +LKI DFGLAR P +T V T WYRAP+++ Sbjct: 117 HDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYT----HEVVTLWYRAPDVL 172 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + SK Y+ +IDIWSVGCI AEM++ P+FPG DQL I ILG+P+ ++ + + Sbjct: 173 MGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELP 232 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 Y + + W D +DLL +ML +PN+RIT ++AL H Y ++ Sbjct: 233 --KYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >4AU8-A nrPDB Length = 296 Score = 189 bits (479), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 110/301 (36%), Positives = 166/301 (55%), Gaps = 16/301 (5%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHEN 99 +Y +L+ IGEG YG V A + VA+K++ + + LREI +L +H+N Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 66 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS--QQLSNDHICYFLYQILRGLKYI 157 ++ + D+L + + + +V + + DL K S L + + FL+Q+L+GL + Sbjct: 67 IVRLHDVLHSD-----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 121 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIM 216 HS NVLHRDLKP NLLIN +LK+ DFGLAR P ++ V T WYR P+++ Sbjct: 122 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA----EVVTLWYRPPDVL 177 Query: 217 LNSKGYTKSIDIWSVGCILAEML-SNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 +K Y+ SID+WS GCI AE+ + RP+FPG DQL I +LG+P++E + + Sbjct: 178 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 237 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 P+ T + + PK ++ DLL +L NP +RI+ EEAL HPY + Sbjct: 238 PDYKPYPMYPATTSL--VNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 295 Query: 336 P 336 P Sbjct: 296 P 296 >1UA2-A nrPDB Length = 346 Score = 186 bits (471), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 113/304 (37%), Positives = 162/304 (53%), Gaps = 19/304 (6%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS---PFEHQTYCQRT-LREIQILLRFR 96 RY +L ++GEG + V A D VAIKKI E + RT LREI++L Sbjct: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILRGL 154 H N+IG+ D + ++ +V D METDL ++K S L+ HI ++ L+GL Sbjct: 71 HPNIIGLLDAFGHKS-----NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAP 213 +Y+H +LHRDLKP+NLL++ LK+ DFGLA+ P +T V TRWYRAP Sbjct: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT----HQVVTRWYRAP 181 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 E++ ++ Y +D+W+VGCILAE+L P PG LDQL I LG+P++E + Sbjct: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 ++ +S P + +F + LDL+ + FNP RIT +AL Y Sbjct: 242 SLPDYVTFKSFPG---IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 Query: 334 YDPT 337 PT Sbjct: 299 PGPT 302 >6GU6-A nrPDB Length = 302 Score = 185 bits (470), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 110/297 (37%), Positives = 164/297 (55%), Gaps = 21/297 (7%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENV 100 YT+++ IGEG YG+V VA+KKI E + +REI +L RH N+ Sbjct: 9 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 68 Query: 101 IGIRDILRASTLEAMRD--VYIVQDLMETDLYKLLKS----QQLSNDHICYFLYQILRGL 154 + ++D+L M+D +Y++ + + DL K L S Q + + + +LYQIL+G+ Sbjct: 69 VSLQDVL-------MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 121 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAP 213 + HS VLHRDLKP NLLI+ +K+ DFGLAR P T V T WYR+P Sbjct: 122 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP----IRVYTHEVVTLWYRSP 177 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 E++L S Y+ +DIWS+G I AE+ + +P+F G +DQL I LG+P+ E + Sbjct: 178 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 237 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 +++ +Y + P + A D LDLL +ML ++P KRI+ + AL HPY Sbjct: 238 SLQ--DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 292 >4KRC-A nrPDB Length = 317 Score = 183 bits (465), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 100/305 (32%), Positives = 164/305 (53%), Gaps = 20/305 (6%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 100 ++ QL+ +G G Y V + VA+K++ + +REI ++ +HEN+ Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSN-------DHICYFLYQILRG 153 + + D++ + +V + M+ DL K + S+ + N + + YF +Q+L+G Sbjct: 66 VRLYDVIHTEN-----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRA 212 L + H +LHRDLKP NLLIN LK+ DFGLAR P + V T WYRA Sbjct: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIP----VNTFSSEVVTLWYRA 176 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 P++++ S+ Y+ SIDIWS GCILAEM++ +P+FPG + +QL I I+G+P++ + Sbjct: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 Query: 273 INMKARN-YLQSLPSKT--KVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY 329 + N +Q P + +V D +D L +L NP+ R++ ++AL HP+ Sbjct: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 Query: 330 LEQYY 334 +YY Sbjct: 297 FAEYY 301 >5AIR-A nrPDB Length = 430 Score = 181 bits (459), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 115/333 (34%), Positives = 177/333 (53%), Gaps = 42/333 (12%) Query: 17 TEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF 76 T G GP P EV YT + IG G++G+V A VAIKK+ Sbjct: 53 TPGQGPDRPQEVS------------YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV--L 98 Query: 77 EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDLMETDLYKLLK 134 + + + R E+QI+ + H N++ +R +S E +VY+ V D + +Y++ + Sbjct: 99 QDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVAR 154 Query: 135 -----SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDLKICDFGLA 188 Q L ++ ++YQ+ R L YIHS + HRD+KP NLL++ T LK+CDFG A Sbjct: 155 HYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSA 214 Query: 189 RI---ADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 + +P Y+ +R+YRAPE++ + YT SID+WS GC+LAE+L +PIF Sbjct: 215 KQLVRGEPN-------VSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF 267 Query: 246 PGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ-SLPSKTKVAWAKLF-PKSDSKA 303 PG +DQL I+ +LG+P++E I NY + P W K+F P++ +A Sbjct: 268 PGDSGVDQLVEIIKVLGTPTREQ----IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEA 323 Query: 304 LDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 + L R+L + P R+T EA AH + ++ DP Sbjct: 324 IALCSRLLEYTPTARLTPLEACAHSFFDELRDP 356 >5G6V-A nrPDB Length = 324 Score = 181 bits (458), Expect = 6e-46, Method: Compositional matrix adjust. Identities = 111/298 (37%), Positives = 160/298 (53%), Gaps = 25/298 (8%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT-LREIQILLRFRHENV 100 Y +L +GEG Y V + VA+K+I EH+ T +RE+ +L +H N+ Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIR-LEHEEGAPCTAIREVSLLKDLKHANI 62 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS-QQLSNDH-ICYFLYQILRGLKYIH 158 + + DI+ + + +V + ++ DL + L + N H + FL+Q+LRGL Y H Sbjct: 63 VTLHDIIHTE-----KSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 117 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLAR---IADPEHDHTGFLTEYVATRWYRAPEI 215 VLHRDLKP NLLIN +LK+ DFGLAR I +D+ V T WYR P+I Sbjct: 118 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNE------VVTLWYRPPDI 171 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN- 274 +L S Y+ ID+W VGCI EM + RP+FPG +QL+ I ILG+P++E I++ Sbjct: 172 LLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSN 231 Query: 275 --MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 K NY P A P+ DS DLL ++L F RI+ E+A+ HP+ Sbjct: 232 EEFKTYNY----PKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >4NST-A nrPDB Length = 351 Score = 180 bits (456), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 112/300 (37%), Positives = 167/300 (55%), Gaps = 13/300 (4%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHEN 99 ++ + IGEG YG V A D VA+KK+ E + + +REI+IL + H + Sbjct: 14 KFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRS 73 Query: 100 VIGIRDIL--RASTLEAMRD---VYIVQDLMETDLYKLLKSQ--QLSNDHICYFLYQILR 152 V+ +++I+ + L+ +D Y+V + M+ DL LL+S S DHI F+ Q++ Sbjct: 74 VVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLME 133 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 GL+Y H N LHRD+K SN+L+N + +K+ DFGLAR+ + E T V T WYR Sbjct: 134 GLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRP--YTNKVITLWYRP 191 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++L + YT +ID+WS GCIL E+ + +PIF L QL I + GSP + Sbjct: 192 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDV 251 Query: 273 INMKARNYLQSLPSKT-KVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 I + N ++ P K + + F S ALDLLD MLT +P+KR T E+ L +L+ Sbjct: 252 IKLPYFNTMK--PKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLK 309 >1G3N-A nrPDB Length = 326 Score = 177 bits (450), Expect = 5e-45, Method: Compositional matrix adjust. Identities = 110/299 (36%), Positives = 161/299 (53%), Gaps = 17/299 (5%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTR-VAIKKIS-PFEHQTYCQRTLREIQILLR---F 95 +Y + IGEGAYG V A D R VA+K++ + T+RE+ +L F Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS---QQLSNDHICYFLYQILR 152 H NV+ + D+ S + + +V + ++ DL L + + I ++Q+LR Sbjct: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 GL ++HS V+HRDLKP N+L+ ++ +K+ DFGLARI + LT V T WYRA Sbjct: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI----YSFQMALTSVVVTLWYRA 187 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++L S Y +D+WSVGCI AEM +P+F G +DQL IL ++G P +ED Sbjct: 188 PEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + + Q+ SK+ K D DLL + LTFNP KRI+ AL+HPY + Sbjct: 247 VALPR----QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 >5EFQ-A nrPDB Length = 347 Score = 175 bits (444), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 112/315 (35%), Positives = 169/315 (53%), Gaps = 14/315 (4%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHEN 99 ++ + IGEG YG V A D VA+KK+ E + + +REI+IL + H++ Sbjct: 12 KFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQS 71 Query: 100 VIGIRDIL--RASTLEAMRD---VYIVQDLMETDLYKLLKSQ--QLSNDHICYFLYQILR 152 +I +++I+ + L+ +D Y+V + M+ DL LL+S + +HI F+ Q++ Sbjct: 72 IINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLME 131 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 GL Y H N LHRD+K SN+L+N +K+ DFGLAR+ E T V T WYR Sbjct: 132 GLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRP--YTNKVITLWYRP 189 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++L + YT +ID+WS GCIL E+ + +PIF L QL I I GSP + Sbjct: 190 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDV 249 Query: 273 INMKARNYLQSLPSKT-KVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 I + N ++ P K + + F + ALDL D ML +P+KR T E+AL +L Sbjct: 250 IKLPYFNTMK--PKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLR 307 Query: 332 QYYDPTDEPVAEEPF 346 +P+ P + P Sbjct: 308 D-VEPSKMPPPDLPL 321 >4E7W-A nrPDB Length = 394 Score = 171 bits (432), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 100/301 (33%), Positives = 173/301 (57%), Gaps = 25/301 (8%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 YT + IG G++G+V A V VAIKK+ + + + R E+QI+ +H NV+ Sbjct: 42 YTNCKVIGNGSFGVVFQA-KLVESDEVAIKKV--LQDKRFKNR---ELQIMRIVKHPNVV 95 Query: 102 GIRDILRASTLEAMRDVYI--VQDLMETDLYKLLK-----SQQLSNDHICYFLYQILRGL 154 ++ ++ + +V++ V + + +Y+ + Q + I ++YQ+LR L Sbjct: 96 DLKAFFYSNG-DKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSL 154 Query: 155 KYIHSANVLHRDLKPSNLLINTTCD-LKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 YIHS + HRD+KP NLL++ LK+ DFG A+I + Y+ +R+YRAP Sbjct: 155 AYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVS----YICSRYYRAP 210 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 E++ + YT +IDIWS GC++AE++ +P+FPG+ +DQL I+ +LG+PS+E + + Sbjct: 211 ELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTM- 269 Query: 274 NMKARNYLQ-SLPSKTKVAWAKLF-PKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 NY++ P ++K+F P++ A+DL+ R+L + P+ R+T EAL HP+ + Sbjct: 270 ---NPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFD 326 Query: 332 Q 332 + Sbjct: 327 E 327 >2W96-B nrPDB Length = 306 Score = 170 bits (431), Expect = 9e-43, Method: Compositional matrix adjust. Identities = 105/299 (35%), Positives = 155/299 (51%), Gaps = 16/299 (5%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR---FR 96 RY + IG GAYG V A D VA+K + P + T+RE+ +L R F Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFE 64 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ---LSNDHICYFLYQILRG 153 H NV+ + D+ S + V +V + ++ DL L L + I + Q LRG Sbjct: 65 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 124 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 L ++H+ ++HRDLKP N+L+ + +K+ DFGLARI + + L V T WYRAP Sbjct: 125 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI----YSYQMALDPVVVTLWYRAP 180 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 E++L S Y +D+WSVGCI AEM +P+F G DQL I ++G P ++D + Sbjct: 181 EVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 239 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 ++ + P + + P+ + LL MLTFNP+KRI+ AL H YL + Sbjct: 240 SLPR----GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 294 >3GC0-A nrPDB Length = 329 Score = 168 bits (425), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 114/334 (34%), Positives = 162/334 (48%), Gaps = 45/334 (13%) Query: 25 PGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQ 83 PG + + RY ++ +GEG YG V A D V VAIK+I E + Sbjct: 19 PGSMSVSAAPSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPG 78 Query: 84 RTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL-KSQQLSNDH 142 +RE+ +L +H N+I ++ ++ + ++++ + E DL K + K+ +S Sbjct: 79 TAIREVSLLKELQHRNIIELKSVIHHN-----HRLHLIFEYAENDLKKYMDKNPDVSMRV 133 Query: 143 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-----TCDLKICDFGLAR-IADPEHD 196 I FLYQ++ G+ + HS LHRDLKP NLL++ T LKI DFGLAR P Sbjct: 134 IKSFLYQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQ 193 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 T + T WYR PEI+L S+ Y+ S+DIWS+ CI AEML P+FPG +DQL Sbjct: 194 ----FTHEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFK 249 Query: 257 ILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLL--------- 307 I +LG P + +LP W + FPK K L + Sbjct: 250 IFEVLGLPDDTTWPGV---------TALPD-----WKQSFPKFRGKTLKRVLGALLDDEG 295 Query: 308 ----DRMLTFNPNKRITVEEALAHPYLEQY-YDP 336 ML +P KRI+ + AL HPY +DP Sbjct: 296 LDLLTAMLEMDPVKRISAKNALEHPYFSHNDFDP 329 >3EB0-A nrPDB Length = 383 Score = 163 bits (413), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 98/332 (29%), Positives = 173/332 (52%), Gaps = 52/332 (15%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 100 +Y+ + +G G++G+V +D R A+KK+ + Y R E+ I+ H N+ Sbjct: 8 KYSLGKTLGTGSFGIVCEVFDIESGKRFALKKV--LQDPRYKNR---ELDIMKVLDHVNI 62 Query: 101 I-------------------------------GIRDILRASTLEAMRDVY--IVQDLMET 127 I G+ + ++ + ++ Y ++ + + Sbjct: 63 IKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPD 122 Query: 128 DLYKLLKS-----QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD-LK 181 L+K+LKS + + + I ++YQ+ R + +IHS + HRD+KP NLL+N+ + LK Sbjct: 123 TLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLK 182 Query: 182 ICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN 241 +CDFG A+ P Y+ +R+YRAPE+ML + YT SID+WS+GC+ E++ Sbjct: 183 LCDFGSAKKLIPSEPSVA----YICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILG 238 Query: 242 RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPK-SD 300 +P+F G+ +DQL I+ I+G+P++E + I M P+ W K+ P+ + Sbjct: 239 KPLFSGETSIDQLVRIIQIMGTPTKEQM---IRMNPHYTEVRFPTLKAKDWRKILPEGTP 295 Query: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 S A+DLL+++L + P+ RI EA+AHP+ + Sbjct: 296 SLAIDLLEQILRYEPDLRINPYEAMAHPFFDH 327 >4BBM-A nrPDB Length = 331 Score = 163 bits (413), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 97/306 (31%), Positives = 166/306 (54%), Gaps = 25/306 (8%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQR-TLREIQILLR 94 F +Y L +GEG+YGMV + VAIKK + ++ +REI++L + Sbjct: 21 FQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQ 80 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICY-----FLYQ 149 RHEN++ + ++ + + Y+V + ++ + +L +L + + Y +L+Q Sbjct: 81 LRHENLVNLLEVCKKK-----KRWYLVFEFVD---HTILDDLELFPNGLDYQVVQKYLFQ 132 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATR 208 I+ G+ + HS N++HRD+KP N+L++ + +K+CDFG AR +A P + + VATR Sbjct: 133 IINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYD----DEVATR 188 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS--PSQ 266 WYRAPE+++ Y K++D+W++GC++ EM P+FPG +DQL HI+ LG+ P Sbjct: 189 WYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRH 248 Query: 267 EDLNCIINMKARNYLQSLPS-KTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 ++L N LP K + + +PK +DL + L +P+KR E L Sbjct: 249 QEL---FNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELL 305 Query: 326 AHPYLE 331 H + + Sbjct: 306 HHDFFQ 311 >4CRL-A nrPDB Length = 406 Score = 160 bits (406), Expect = 7e-40, Method: Compositional matrix adjust. Identities = 110/327 (33%), Positives = 163/327 (49%), Gaps = 38/327 (11%) Query: 48 IGEGAYGMV--SSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 +G G YG V + D A+K+I E REI +L +H NVI ++ Sbjct: 30 VGRGTYGHVYKAKRKDGKDDKDYALKQI---EGTGISMSACREIALLRELKHPNVISLQK 86 Query: 106 ILRASTLEAMRDVYIVQDLMETDLYKLLKSQ----------QLSNDHICYFLYQILRGLK 155 + + A R V+++ D E DL+ ++K QL + LYQIL G+ Sbjct: 87 VFLS---HADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIH 143 Query: 156 YIHSANVLHRDLKPSNLLIN----TTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 Y+H+ VLHRDLKP+N+L+ +KI D G AR+ + L V T WYR Sbjct: 144 YLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYR 203 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK---------HYLDQLNHILGILG 262 APE++L ++ YTK+IDIW++GCI AE+L++ PIF + ++ DQL+ I ++G Sbjct: 204 APELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMG 263 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFP-------KSDSKALDLLDRMLTFNP 315 P+ +D I M + L + L K DSKA LL ++LT +P Sbjct: 264 FPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDP 323 Query: 316 NKRITVEEALAHPYLEQYYDPTDEPVA 342 KRIT E+A+ PY + PT + A Sbjct: 324 IKRITSEQAMQDPYFLEDPLPTSDVFA 350 >3E3P-A nrPDB Length = 360 Score = 160 bits (405), Expect = 9e-40, Method: Compositional matrix adjust. Identities = 99/311 (31%), Positives = 164/311 (52%), Gaps = 23/311 (7%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 100 R+ + G+G +G V + VAIKK+ + + R L+ +Q L H N+ Sbjct: 24 RFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV--IQDPRFRNRELQIMQDLAVLHHPNI 81 Query: 101 IGIRDILRASTLEAMRDVY--IVQDLMETDLYKLLKS---QQLSNDHIC--YFLYQILRG 153 + ++ RD+Y +V + + L++ ++ +Q++ I FL+Q++R Sbjct: 82 VQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIRS 141 Query: 154 LKYIH--SANVLHRDLKPSNLLINTT-CDLKICDFGLARIADPEHDHTGFLTEYVATRWY 210 + +H S NV HRD+KP N+L+N LK+CDFG A+ P + Y+ +R+Y Sbjct: 142 IGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVA----YICSRYY 197 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 RAPE++ ++ YT ++DIWSVGCI AEM+ PIF G + QL+ I+ +LG PS+E L Sbjct: 198 RAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLR 257 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFP----KSDSKALDLLDRMLTFNPNKRITVEEALA 326 + + L + + W+ +F K +A DLL +L + P +R+ EAL Sbjct: 258 ---KLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALC 314 Query: 327 HPYLEQYYDPT 337 HPY ++ +DP Sbjct: 315 HPYFDELHDPA 325 >4BGQ-A nrPDB Length = 304 Score = 159 bits (402), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 98/306 (32%), Positives = 163/306 (53%), Gaps = 26/306 (8%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRF 95 +V ++ L +GEGAYG+V VAIKK E ++ + TLRE+++L Sbjct: 9 NVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTL 68 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS--QQLSNDHICYFLYQILRG 153 + EN++ +++ R +Y+V + +E ++ +LL+ + + + ++YQ+++ Sbjct: 69 KQENIVELKEAFRRRG-----KLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKA 123 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 + + H +++HRD+KP NLLI+ LK+CDFG AR + + E VATRWYR+P Sbjct: 124 IHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFAR--NLSEGNNANYDEEVATRWYRSP 181 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI- 272 E++L + Y KS+D+WSVGCIL E+ +P+FPG+ +DQL I +LG E + Sbjct: 182 ELLLGAP-YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFY 240 Query: 273 -------INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 + A N+ QSL + +S LDL+ +L +P R E+ L Sbjct: 241 SNPRFHGLRFPAVNHPQSLER-------RYLGILNSVLLDLMKNLLKLDPADRYLTEQCL 293 Query: 326 AHPYLE 331 HP + Sbjct: 294 NHPTFQ 299 >4AGU-A nrPDB Length = 311 Score = 156 bits (394), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 97/300 (32%), Positives = 160/300 (53%), Gaps = 21/300 (7%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQR-TLREIQILLRFRHEN 99 +Y ++ IGEG+YG+V + VAIKK E ++ LREI++L + +H N Sbjct: 4 KYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPN 63 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSNDHICYFL-YQILRGLKYI 157 ++ + ++ R R +++V + + T L++L + Q+ +H+ + +Q L+ + + Sbjct: 64 LVNLLEVFRRK-----RRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFC 118 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 H N +HRD+KP N+LI +K+CDFG AR+ D + + VATRWYR+PE+++ Sbjct: 119 HKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSD---YYDDEVATRWYRSPELLV 175 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS--PSQEDLNCIINM 275 Y +D+W++GC+ AE+LS P++PGK +DQL I LG P + + Sbjct: 176 GDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQV-----F 230 Query: 276 KARNYLQ--SLPSKTKVAWAKL-FPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 Y +P + +L FP AL LL L +P +R+T E+ L HPY E Sbjct: 231 STNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFEN 290 >3MIA-A nrPDB Length = 351 Score = 155 bits (392), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 106/313 (33%), Positives = 159/313 (50%), Gaps = 9/313 (2%) Query: 35 PF-DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQIL 92 PF D +Y +L IG+G +G V A +VA+KK+ E + + LREI+IL Sbjct: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 Query: 93 LRFRHENVIGIRDILRASTLEAMR---DVYIVQDLMETDLYKLLKSQ--QLSNDHICYFL 147 +HENV+ + +I R R +Y+V D E DL LL + + + I + Sbjct: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVM 130 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVA 206 +L GL YIH +LHRD+K +N+LI LK+ DFGLAR + ++ T V Sbjct: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 T WYR PE++L + Y ID+W GCI+AEM + PI G QL I + GS + Sbjct: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPK-SDSKALDLLDRMLTFNPNKRITVEEAL 325 E + N + L+ + + + +L D ALDL+D++L +P +RI ++AL Sbjct: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 Query: 326 AHPYLEQYYDPTD 338 H + P+D Sbjct: 311 NHDFFWSDPMPSD 323 >3ZDU-A nrPDB Length = 325 Score = 149 bits (376), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 92/304 (30%), Positives = 152/304 (50%), Gaps = 36/304 (11%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 Y L +GEG+YG V VAIK Q+ + +REI+ L +F HEN++ Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLV 64 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILRGLKYIHS 159 + ++ R + +++V + ++ + L+ L + + +L+QILR + Y+HS Sbjct: 65 NLIEVFRQK-----KKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHS 119 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 N++HRD+KP N+L++ + K+CDFG AR D + VATRWYRAPE++L Sbjct: 120 NNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGD---IYDDEVATRWYRAPELVLKD 176 Query: 220 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN 279 Y K +DIW++GC++ EM + P P LD L+ I+ +G+ S Sbjct: 177 TSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSP------------- 223 Query: 280 YLQSLPSKTKVAWA-------------KLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 +LQ++ SK+ + K +PK + D++ L +P RI+ + L Sbjct: 224 HLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLH 283 Query: 327 HPYL 330 H Y Sbjct: 284 HEYF 287 >5Y86-A nrPDB Length = 588 Score = 138 bits (347), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 96/326 (29%), Positives = 163/326 (50%), Gaps = 43/326 (13%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 100 RY L+ IG+G++G V+ YDH + VA+K + + + ++ EI+IL + ++ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKRFHRQAAEEIRILEHLKKQDK 265 Query: 101 IGIRDILRASTLEAMRD-VYIVQDLMETDLYKLLKS---QQLSNDHICYFLYQILRGLKY 156 G +++ R+ V + +L+ DLY+L+K Q S + F IL+ L Sbjct: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 Query: 157 IHSANVLHRDLKPSNLLI--NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 +H ++H DLKP N+L+ + K+ DFG + + L Y+ +R+YRAPE Sbjct: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQK------LYTYIQSRFYRAPE 379 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP---------- 264 I+L S+ Y+ IDIWS GCILAE+L+ +P+FPG+ DQL ++ +LG P Sbjct: 380 IILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKR 438 Query: 265 -----------------SQEDLNCI-INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDL 306 +Q D + + ++R + P +K L D ++ Sbjct: 439 AKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEF 498 Query: 307 LDRMLTFNPNKRITVEEALAHPYLEQ 332 L R L ++P+ R+T +AL HP++ + Sbjct: 499 LKRCLHWDPSARLTPAQALRHPWISK 524 >5ZTN-A nrPDB Length = 429 Score = 134 bits (336), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 102/337 (30%), Positives = 167/337 (49%), Gaps = 52/337 (15%) Query: 35 PFD-VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILL 93 P D V RY L+ IG+G++G V AYDH VA+K + + + ++ EI+IL Sbjct: 91 PHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVR--NEKRFHRQAAEEIRILE 148 Query: 94 RFRHE---NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS---QQLSNDHICYFL 147 R + N + + +L T + + +L+ +LY+L+K Q S + F Sbjct: 149 HLRKQDKDNTMNVIHMLENFTFR--NHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFA 206 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTT--CDLKICDFGLARIADPEHDHTGFLTEYV 205 + IL+ L +H ++H DLKP N+L+ +K+ DFG + ++H T Y+ Sbjct: 207 HSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS-----CYEHQRVYT-YI 260 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 +R+YRAPE++L ++ Y ID+WS+GCILAE+L+ P+ PG+ DQL ++ +LG PS Sbjct: 261 QSRFYRAPEVILGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPS 319 Query: 266 QEDLNCIINMKARNYLQS--LPSKTKVA---------------------------WAKLF 296 Q+ L+ + +A+N++ S P V W Sbjct: 320 QKLLDA--SKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNAL 377 Query: 297 PKSDSKA-LDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 D LD L + L ++P R+T +AL HP+L + Sbjct: 378 KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRR 414 >3NCG-A nrPDB Length = 486 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 94/319 (29%), Positives = 155/319 (48%), Gaps = 48/319 (15%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT-LREIQILLRFRH 97 RY + +G+G++G V D + + A+K I+ + T LRE+++L + H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMET-DLY-KLLKSQQLSNDHICYFLYQILRGLK 155 N++ + +IL S+ YIV +L +L+ +++K ++ S + Q+ G+ Sbjct: 81 PNIMKLFEILEDSS-----SFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGIT 135 Query: 156 YIHSANVLHRDLKPSNLLINTT---CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 Y+H N++HRDLKP N+L+ + CD+KI DFGL+ + + + T +Y A Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTC----FQQNTKMKDRIGTAYYIA 191 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++ + Y + D+WS G IL +LS P F GK+ D L + Sbjct: 192 PEVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV--------------- 234 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 + Y LP W + SD A DL+ +MLTF+P+ RIT + L HP++++ Sbjct: 235 ---ETGKYAFDLPQ-----WRTI---SDD-AKDLIRKMLTFHPSLRITATQCLEHPWIQK 282 Query: 333 YYDPT----DEPVAEEPFT 347 Y T D P E T Sbjct: 283 YSSETPTISDLPSLESAMT 301 >6O6Q-A nrPDB Length = 335 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 89/301 (29%), Positives = 159/301 (52%), Gaps = 26/301 (8%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-ENV 100 Y L+ +G G Y V D ++ +V IK + P + + + REI IL N+ Sbjct: 43 YEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRK----KIKREISILKNLVDGPNI 98 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSA 160 I + D++R ++ I + + D L + ++ I +++Y++L+ L Y HS Sbjct: 99 IAMLDVVREP--QSKTPGLIFEHINNIDFRSLYPT--FTDYDIRFYMYELLKALDYSHSM 154 Query: 161 NVLHRDLKPSNLLINTTCDL-KICDFGLARIADPEHDHTGFLTEY---VATRWYRAPEIM 216 ++HRD+KP N++I+ L ++ D+GLA E+ H G TEY VA+R+++ PE++ Sbjct: 155 GIMHRDVKPHNVMIDHDKKLLRLIDWGLA-----EYYHPG--TEYNVRVASRYFKGPELL 207 Query: 217 LNSKGYTKSIDIWSVGCILAEML-SNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 ++ + Y S+D+WS GC+LA M+ P F GK DQL I+ +LGS + + N+ Sbjct: 208 VDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNI 267 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDS-----KALDLLDRMLTFNPNKRITVEEALAHPYL 330 + + K W + +++ + LDL+DR+L ++ +R+T +EA+ H Y Sbjct: 268 SLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYF 327 Query: 331 E 331 + Sbjct: 328 D 328 >3DFA-A nrPDB Length = 286 Score = 126 bits (317), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 89/299 (29%), Positives = 150/299 (50%), Gaps = 44/299 (14%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT-LREIQILLRFRHEN 99 RY + +G+G++G V D + + A+K I+ + T LRE+++L + H N Sbjct: 23 RYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPN 82 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMET-DLY-KLLKSQQLSNDHICYFLYQILRGLKYI 157 ++ + +IL S+ YIV +L +L+ +++K ++ S + Q+ G+ Y+ Sbjct: 83 IMKLFEILEDSS-----SFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYM 137 Query: 158 HSANVLHRDLKPSNLLINTT---CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 H N++HRDLKP N+L+ + CD+KI DFGL+ + + + T +Y APE Sbjct: 138 HKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTC----FQQNTKMKDRIGTAYYIAPE 193 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 ++ + Y + D+WS G IL +LS P F GK+ D L + Sbjct: 194 VLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV----------------- 234 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 + Y LP W + SD A DL+ +MLTF+P+ RIT + L HP++++Y Sbjct: 235 -ETGKYAFDLPQ-----WRTI---SDD-AKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >2YCR-A nrPDB Length = 323 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 92/304 (30%), Positives = 147/304 (48%), Gaps = 50/304 (16%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTL-------REIQILLR 94 Y + +G GA G V A++ +VAIK IS + R EI+IL + Sbjct: 12 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKK 71 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLY-KLLKSQQLSNDHICYFLYQILR 152 H +I I++ A D YIV +LME +L+ K++ +++L + YQ+L Sbjct: 72 LNHPCIIKIKNFFDA------EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 125 Query: 153 GLKYIHSANVLHRDLKPSNLLINTT---CDLKICDFGLARIADPEHDHTGFLTEYVATRW 209 ++Y+H ++HRDLKP N+L+++ C +KI DFG ++I T + T Sbjct: 126 AVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL----GETSLMRTLCGTPT 181 Query: 210 YRAPEIMLN--SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 Y APE++++ + GY +++D WS+G IL LS P F +Q Sbjct: 182 YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHR---------------TQV 226 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAH 327 L I N++ + WA++ KALDL+ ++L +P R T EEAL H Sbjct: 227 SLKDQITSGKYNFIPEV-------WAEV----SEKALDLVKKLLVVDPKARFTTEEALRH 275 Query: 328 PYLE 331 P+L+ Sbjct: 276 PWLQ 279 >5XVU-A nrPDB Length = 332 Score = 122 bits (307), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 70/207 (33%), Positives = 121/207 (58%), Gaps = 18/207 (8%) Query: 137 QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN-TTCDLKICDFGLARIADPEH 195 + ++ I Y++YQIL+ L Y HS ++HRD+KP N++I+ +++ +GLA P Sbjct: 121 KFTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQ 180 Query: 196 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQL 254 ++ VA+R+Y+ PE++++ + Y S+DIWS+GC+LA M+ + P F G DQL Sbjct: 181 EYNV----RVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQL 236 Query: 255 NHILGILGSPSQEDLNCII---NMKAR-NYLQSLPSKTKVAWAKLFPKSD-----SKALD 305 I +LG+ EDL+ + N+K + +YL L + W+ +S+ + +D Sbjct: 237 VKIAKVLGT---EDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVID 293 Query: 306 LLDRMLTFNPNKRITVEEALAHPYLEQ 332 L+D+ML ++ KRI +EA+ HPY + Sbjct: 294 LIDKMLIYDHAKRIAPKEAMEHPYFRE 320 >3I6U-A nrPDB Length = 419 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 91/304 (29%), Positives = 147/304 (48%), Gaps = 50/304 (16%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTL-------REIQILLR 94 Y + +G GA G V A++ +VAI+ IS + R EI+IL + Sbjct: 137 YIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILKK 196 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLY-KLLKSQQLSNDHICYFLYQILR 152 H +I I++ A D YIV +LME +L+ K++ +++L + YQ+L Sbjct: 197 LNHPCIIKIKNFFDAE------DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 250 Query: 153 GLKYIHSANVLHRDLKPSNLLINTT---CDLKICDFGLARIADPEHDHTGFLTEYVATRW 209 ++Y+H ++HRDLKP N+L+++ C +KI DFG ++I T + T Sbjct: 251 AVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL----GETSLMRTLCGTPT 306 Query: 210 YRAPEIMLN--SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 Y APE++++ + GY +++D WS+G IL LS P F +Q Sbjct: 307 YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHR---------------TQV 351 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAH 327 L I N++ + WA++ KALDL+ ++L +P R T EEAL H Sbjct: 352 SLKDQITSGKYNFIPEV-------WAEV----SEKALDLVKKLLVVDPKARFTTEEALRH 400 Query: 328 PYLE 331 P+L+ Sbjct: 401 PWLQ 404 >6EII-A nrPDB Length = 352 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 73/242 (30%), Positives = 131/242 (54%), Gaps = 20/242 (8%) Query: 99 NVIGIRDILR--ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKY 156 N+I + DI++ S A+ + + + TD +L Q L++ I +++Y+IL+ L Y Sbjct: 116 NIITLADIVKDPVSRTPAL----VFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDY 169 Query: 157 IHSANVLHRDLKPSNLLINTTC-DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 HS ++HRD+KP N++I+ L++ D+GLA P ++ VA+R+++ PE+ Sbjct: 170 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV----RVASRYFKGPEL 225 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 +++ + Y S+D+WS+GC+LA M+ + P F G DQL I +LG+ D N Sbjct: 226 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 285 Query: 275 MKAR-NYLQSLPSKTKVAWAKLFPKSDS-----KALDLLDRMLTFNPNKRITVEEALAHP 328 ++ + L ++ W + + +ALD LD++L ++ R+T EA+ HP Sbjct: 286 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 345 Query: 329 YL 330 Y Sbjct: 346 YF 347 >4MD7-E nrPDB Length = 391 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 71/240 (29%), Positives = 129/240 (53%), Gaps = 16/240 (6%) Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 N+I + DI++ + + + + TD +L Q L++ I +++Y+IL+ L Y H Sbjct: 93 NIITLADIVKDPV--SRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCH 148 Query: 159 SANVLHRDLKPSNLLINTTC-DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 S ++HRD+KP N++I+ L++ D+GLA P ++ VA+R+++ PE+++ Sbjct: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEY----NVRVASRYFKGPELLV 204 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + + Y S+D+WS+GC+LA M+ + P F G DQL I +LG+ D N++ Sbjct: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 Query: 277 AR-NYLQSLPSKTKVAWAKLFPKSDS-----KALDLLDRMLTFNPNKRITVEEALAHPYL 330 + L ++ W + + +ALD LD++L ++ R+T EA+ HPY Sbjct: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 >5X8I-B nrPDB Length = 346 Score = 117 bits (292), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 97/340 (28%), Positives = 145/340 (42%), Gaps = 64/340 (18%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTR-VAIKKISPFEHQTYCQRTLREIQILLRFR 96 + RY + +GEGA+G V DH R VA+K + + YC+ EIQ+L Sbjct: 11 LSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVD--RYCEAARSEIQVL---E 65 Query: 97 HENVIGIRDILRASTL----EAMRDVYIVQDLMETDLYKLLKSQQL---SNDHICYFLYQ 149 H N R + E + IV +L+ Y +K DHI YQ Sbjct: 66 HLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQ 125 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTC-------------------DLKICDFGLARI 190 I + + ++HS + H DLKP N+L + D+K+ DFG A Sbjct: 126 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY 185 Query: 191 ADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFP---G 247 D H + V+TR YRAPE++L + G+++ D+WS+GCIL E +FP Sbjct: 186 DDEHH------STLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTHDS 238 Query: 248 KHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQS-------------LPSKTKVAWAK 294 K +L + ILG L + I + R Y S+ + Sbjct: 239 KEHLAMMERILGPLPK------HMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKE 292 Query: 295 LFPKSD---SKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 D + DL+ +ML ++P KRIT+ EAL HP+ + Sbjct: 293 FMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFD 332 >5JN2-A nrPDB Length = 525 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 93/343 (27%), Positives = 157/343 (45%), Gaps = 57/343 (16%) Query: 8 GGGGGEPRR------TEGVGPG-----VPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMV 56 GG GEPR T G GPG PG V+ RY + +G+G++G V Sbjct: 27 GGAAGEPRSRGHAAGTSG-GPGDHLHATPGM--FVQHSTAIFSDRYKGQRVLGKGSFGEV 83 Query: 57 SSAYDHVRKTRVAIKKISP--FEHQTYCQRTLREIQILLRFRHENVIGIRDILR-ASTLE 113 D + A+K IS + +T + LRE+Q+L + H N++ + + Sbjct: 84 ILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFY 143 Query: 114 AMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL 173 + +VY +L + +++ ++ S + Q+L G+ Y+H ++HRDLKP NLL Sbjct: 144 LVGEVYTGGELFD----EIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLL 199 Query: 174 INTT---CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWS 230 + + +++I DFGL+ + + + + + T +Y APE++ + Y + D+WS Sbjct: 200 LESKSKDANIRIIDFGLS----THFEASKKMKDKIGTAYYIAPEVLHGT--YDEKCDVWS 253 Query: 231 VGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKV 290 G IL +LS P F G + D L + + Y LP KV Sbjct: 254 TGVILYILLSGCPPFNGANEYDILKKV------------------EKGKYTFELPQWKKV 295 Query: 291 AWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 + A DL+ +MLT+ P+ RI+ +AL H +++ Y Sbjct: 296 S---------ESAKDLIRKMLTYVPSMRISARDALDHEWIQTY 329 >6HMD-A nrPDB Length = 365 Score = 116 bits (290), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 71/239 (29%), Positives = 126/239 (52%), Gaps = 28/239 (11%) Query: 120 IVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN-TTC 178 + + + TD +L Q L++ I +++Y++L+ L Y HS ++HRD+KP N++I+ Sbjct: 128 VFEYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQK 185 Query: 179 DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM 238 L++ D+GLA P ++ VA+R+++ PE++++ + Y S+D+WS+GC+LA M Sbjct: 186 KLRLIDWGLAEFYHPAQEYNV----RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASM 241 Query: 239 LSNR-PIFPGKHYLDQLNHILGILGSPS--------QEDLNCIINMKARNYLQSLPSKTK 289 + R P F G+ DQL I +LG+ DL+ N L ++ Sbjct: 242 IFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFN-------DILGQHSR 294 Query: 290 VAWAKLFPKSDS-----KALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAE 343 W + +ALDLLD++L ++ +R+T +EA+ HPY +P A+ Sbjct: 295 KRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPSAD 353 >2PVN-A nrPDB Length = 352 Score = 115 bits (289), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 75/246 (30%), Positives = 139/246 (56%), Gaps = 24/246 (9%) Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 N++ + DI+R + I + + TD L + L++ I Y++Y++L+ L Y H Sbjct: 108 NIVKLLDIVRDQ--HSKTPSLIFEYVNNTDFKVLYPT--LTDYDIRYYIYELLKALDYCH 163 Query: 159 SANVLHRDLKPSNLLINTTC-DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 S ++HRD+KP N++I+ L++ D+GLA P ++ VA+R+++ PE+++ Sbjct: 164 SQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEY----NVRVASRYFKGPELLV 219 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIIN-- 274 + + Y S+D+WS+GC+ A M+ + P F G DQL I +LG+ + LN +N Sbjct: 220 DLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGT---DGLNAYLNKY 276 Query: 275 -MKARNYLQSLPSK-TKVAWAKLFPKSDSK------ALDLLDRMLTFNPNKRITVEEALA 326 ++ L++L + ++ W K F +D++ A+D LD++L ++ +R+T EA+ Sbjct: 277 RIELDPQLEALVGRHSRKPWLK-FMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMT 335 Query: 327 HPYLEQ 332 HPY +Q Sbjct: 336 HPYFQQ 341 >3HZT-A nrPDB Length = 467 Score = 114 bits (286), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 89/320 (27%), Positives = 148/320 (46%), Gaps = 45/320 (14%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIK--KISPFEHQTYCQRTLREIQILLRF 95 + RY +++ +G GAYG V D + AIK K S + L E+ +L + Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLY-KLLKSQQLSNDHICYFLYQILRG 153 H N++ + + E R+ Y+V ++ +L+ +++ Q+ S + Q+L G Sbjct: 62 DHPNIMKLYEFF-----EDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSG 116 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWY 210 Y+H N++HRDLKP NLL+ + +KI DFGL+ + G + E + T +Y Sbjct: 117 TTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLS----AHFEVGGKMKERLGTAYY 172 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 APE++ K Y + D+WS G IL +L P F G Q D Sbjct: 173 IAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGG------------------QTDQE 212 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + ++ + P T+V+ +A L+ MLT+ P+KRI+ EEAL HP++ Sbjct: 213 ILKRVEKGKFSFDPPDWTQVS---------DEAKQLVKLMLTYEPSKRISAEEALNHPWI 263 Query: 331 EQYYDPTDEPVAEEPFTFAM 350 ++ V + T A+ Sbjct: 264 VKFCSQKHTDVGKHALTGAL 283 >3DXN-A nrPDB Length = 287 Score = 112 bits (280), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 86/300 (28%), Positives = 142/300 (47%), Gaps = 45/300 (15%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIK--KISPFEHQTYCQRTLREIQILLRFRHE 98 RY +++ +G GAYG V D + AIK K S + L E+ +L + H Sbjct: 22 RYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHP 81 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMET-DLY-KLLKSQQLSNDHICYFLYQILRGLKY 156 N++ + + E R+ Y+V ++ +L+ +++ Q+ S + Q+L G Y Sbjct: 82 NIMKLYEFF-----EDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTY 136 Query: 157 IHSANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 +H N++HRDLKP NLL+ + +KI DFGL+ + G + E + T +Y AP Sbjct: 137 LHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLS----AHFEVGGKMKERLGTAYYIAP 192 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 E++ K Y + D+WS G IL +L P F G Q D + Sbjct: 193 EVL--RKKYDEKCDVWSCGVILYILLCGYPPFGG------------------QTDQEILK 232 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 ++ + P T+V+ +A L+ MLT+ P+KRI+ EEAL HP++ ++ Sbjct: 233 RVEKGKFSFDPPDWTQVS---------DEAKQLVKLMLTYEPSKRISAEEALNHPWIVKF 283 >6FYV-A nrPDB Length = 337 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 94/334 (28%), Positives = 142/334 (42%), Gaps = 58/334 (17%) Query: 41 RYTQLQYIGEGAYGMVSSAYDH-VRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 RY + +GEGA+G V DH + VA+K + Y + EIQ+L H N Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNV--GRYREAARSEIQVL---EHLN 69 Query: 100 VIGIRDILRASTLEAMRD----VYIVQDLMETDLYKLLKSQQL---SNDHICYFLYQILR 152 + R + D V IV +L+ Y +K DHI YQI + Sbjct: 70 STDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQ 129 Query: 153 GLKYIHSANVLHRDLKPSNLLINTT-------------------CDLKICDFGLARIADP 193 + ++H + H DLKP N+L + D+K+ DFG A D Sbjct: 130 SINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDE 189 Query: 194 EHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQ 253 H + V+TR YRAPE++L + G+++ D+WS+GCIL E +F + Sbjct: 190 HH------STLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEH 242 Query: 254 LNHILGILGSPSQEDLNCIINMKARNYLQ-------SLPSKTKVAWAKLFP--------- 297 L + ILG Q + I + R Y S + + P Sbjct: 243 LAMMERILGPIPQ---HMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHD 299 Query: 298 KSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + K DL+ RML ++P +RIT++EAL HP+ + Sbjct: 300 EEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFD 333 >3MA6-A nrPDB Length = 298 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 83/319 (26%), Positives = 148/319 (46%), Gaps = 48/319 (15%) Query: 21 GPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP--FEH 78 GPG+ V+ RY + +G+G++G V D + A+K IS + Sbjct: 18 GPGM-----FVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQ 72 Query: 79 QTYCQRTLREIQILLRFRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQ 137 +T + LRE+Q+L + H N++ + + + +VY +L + +++ ++ Sbjct: 73 KTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFD----EIISRKR 128 Query: 138 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT---CDLKICDFGLARIADPE 194 S + Q+L G+ Y+H ++HRDLKP NLL+ + +++I DFGL+ Sbjct: 129 FSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLS----TH 184 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 + + + + + T +Y APE++ + Y + D+WS G IL +LS P F G + D L Sbjct: 185 FEASKKMKDKIGTAYYIAPEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDIL 242 Query: 255 NHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFN 314 + + Y LP KV+ A DL+ +MLT+ Sbjct: 243 KKV------------------EKGKYTFELPQWKKVS---------ESAKDLIRKMLTYV 275 Query: 315 PNKRITVEEALAHPYLEQY 333 P+ RI+ +AL H +++ Y Sbjct: 276 PSMRISARDALDHEWIQTY 294 >3LIJ-A nrPDB Length = 494 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 81/297 (27%), Positives = 140/297 (47%), Gaps = 44/297 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ-RTLREIQILLRFRHENV 100 Y +++ +G GAYG V D V AIK I T + L E+ +L H N+ Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNI 98 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMET-DLY-KLLKSQQLSNDHICYFLYQILRGLKYIH 158 + + D E R+ Y+V + + +L+ +++ + + + Q+L G+ Y+H Sbjct: 99 MKLYDFF-----EDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLH 153 Query: 159 SANVLHRDLKPSNLLINTT---CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 N++HRDLKP NLL+ + +KI DFGL+ + + + + E + T +Y APE+ Sbjct: 154 KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKK----MKERLGTAYYIAPEV 209 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + K Y + D+WS+G IL +L+ P F G Q D + + Sbjct: 210 L--RKKYDEKCDVWSIGVILFILLAGYPPFGG------------------QTDQEILRKV 249 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 + Y P V+ A DL+ +ML F+ +RI+ ++AL HP++++ Sbjct: 250 EKGKYTFDSPEWKNVSEG---------AKDLIKQMLQFDSQRRISAQQALEHPWIKE 297 >4MVF-A nrPDB Length = 506 Score = 108 bits (270), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 84/298 (28%), Positives = 138/298 (46%), Gaps = 46/298 (15%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 100 +Y + +G+G YG V D V AIK+ + R +EI+I+ + H N+ Sbjct: 58 KYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKE-EKKDRLKNINRFFQEIEIMKKLDHPNI 116 Query: 101 IGIRDILRASTLEAMRDVYIVQDLME-TDLY-KLLKSQQLSNDHICYFLYQILRGLKYIH 158 + + + T E +Y++ +L +L+ ++++ + + + QI + Y+H Sbjct: 117 VKLYE-----TYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLH 171 Query: 159 SANVLHRDLKPSNLLI---NTTCDLKICDFGLARIADPEHDHTG-FLTEYVATRWYRAPE 214 S N++HRDLKP N L N LKI DFGL++ + TG F T T +Y AP+ Sbjct: 172 SLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSK-----NLGTGEFTTTKAGTPYYVAPQ 226 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 ++ Y K DIWS G I+ +L P F G D N + Sbjct: 227 VL--DGKYDKKCDIWSSGVIMYTLLCGYPPFYG----DTDNEV----------------- 263 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 L+ + + + S A +L+ ++LT+NPN+R T+EEAL HP++ Q Sbjct: 264 ------LKKVKKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQ 315 >4NIF-A nrPDB Length = 333 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 89/299 (29%), Positives = 138/299 (46%), Gaps = 47/299 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF-RHENV 100 Y + IG G+Y A+K I + EI+ILLR+ +H N+ Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPS-----EEIEILLRYGQHPNI 64 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 I ++D+ + + VY+V +LM L K+L+ + S + L+ I + ++Y+H Sbjct: 65 ITLKDVY-----DDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 119 Query: 159 SANVLHRDLKPSNLLI-----NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 S V+HRDLKPSN+L N C L+ICDFG A+ E+ G L T + AP Sbjct: 120 SQGVVHRDLKPSNILYVDESGNPEC-LRICDFGFAKQLRAEN---GLLMTPCYTANFVAP 175 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 E+ L +GY + DIWS+G +L ML+ F D IL +GS Sbjct: 176 EV-LKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPS-DTPEEILTRIGSGK-------F 226 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 + N W + A DL+ +ML +P++R+T ++ L HP++ Q Sbjct: 227 TLSGGN------------WNTV----SETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQ 269 >1PHK-A nrPDB Length = 298 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 81/272 (29%), Positives = 123/272 (45%), Gaps = 50/272 (18%) Query: 73 ISPFEHQTYCQRTLREIQILLRFR-HENVIGIRDILRASTLEAMRDVYIVQDLMET-DLY 130 S E Q + TL+E+ IL + H N+I ++D +T ++V DLM+ +L+ Sbjct: 58 FSAEEVQELREATLKEVDILRKVSGHPNIIQLKDTYETNTF-----FFLVFDLMKKGELF 112 Query: 131 KLLKSQ-QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR 189 L + LS + +L + +H N++HRDLKP N+L++ ++K+ DFG + Sbjct: 113 DYLTEKVTLSEKETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSC 172 Query: 190 IADPEHDHTGFLTEYVATRWYRAPEIML-----NSKGYTKSIDIWSVGCILAEMLSNRPI 244 DP L E T Y APEI+ N GY K +D+WS G I+ +L+ P Sbjct: 173 QLDPGEK----LREVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPP 228 Query: 245 FPGKHYLDQLNHILG---ILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDS 301 F + + L I+ GSP +D + + Sbjct: 229 FWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVK--------------------------- 261 Query: 302 KALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 DL+ R L P KR T EEALAHP+ +QY Sbjct: 262 ---DLVSRFLVVQPQKRYTAEEALAHPFFQQY 290 >4IAN-A nrPDB Length = 358 Score = 105 bits (263), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 97/335 (28%), Positives = 160/335 (47%), Gaps = 58/335 (17%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTR-VAIKKISPFEHQTYCQRT-LREIQILLRFRHE 98 RY Y G+G + V A D+ R + VA+K I E Q+T L+E++ L + Sbjct: 31 RYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNE---LMQKTGLKELEFLKKLNDA 87 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDL------METDLYKLLKSQQ----LSNDHICYFLY 148 + + L R Y Q L + +L ++LK L + + Sbjct: 88 DPDD-----KFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQ 142 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLIN-TTCDLKICDFGLA-RIADPEHDHTGFLTEYVA 206 Q+ LK + N+LH D+KP N+L+N + LK+CDFG A +AD + +T Y+ Sbjct: 143 QLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND------ITPYLV 196 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS-PS 265 +R+YRAPEI++ K Y ID+WSVGC L E+ + + +FPGK L + + G P+ Sbjct: 197 SRFYRAPEIII-GKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPN 255 Query: 266 Q-------------EDLNCI------INMKARNYLQSLPSKTKVAWAKL-----FPKSDS 301 + ++LN + + + + + S + TK A L P+ Sbjct: 256 KMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQR 315 Query: 302 KAL----DLLDRMLTFNPNKRITVEEALAHPYLEQ 332 K + DLLD++L +P KRI++ +AL H ++++ Sbjct: 316 KKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >3Q5I-A nrPDB Length = 504 Score = 105 bits (261), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 90/333 (27%), Positives = 150/333 (45%), Gaps = 62/333 (18%) Query: 19 GVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMV---SSAYDHVRKTRVAIKKISP 75 + PG+ V+ + +G Y +++ +G GAYG V H K IKK S Sbjct: 20 AINPGM-----YVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKK-SQ 73 Query: 76 FEHQTYC----------QRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM 125 F+ Y + EI +L H N+I + D+ E + Y+V + Sbjct: 74 FDKGRYSDDNKNIEKFHEEIYNEISLLKSLDHPNIIKLFDVF-----EDKKYFYLVTEFY 128 Query: 126 ET-DLY-KLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLI---NTTCDL 180 E +L+ +++ + + QIL G+ Y+H N++HRD+KP N+L+ N+ ++ Sbjct: 129 EGGELFEQIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNI 188 Query: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 KI DFGL+ ++ L + + T +Y APE++ K Y + D+WS G I+ +L Sbjct: 189 KIVDFGLSSFFSKDYK----LRDRLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYILLC 242 Query: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300 P F G Q D + I ++ Y W + SD Sbjct: 243 GYPPFGG------------------QNDQDIIKKVEKGKYYFDFND-----WKNI---SD 276 Query: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 +A +L+ MLT++ NKR T EEAL ++++Y Sbjct: 277 -EAKELIKLMLTYDYNKRCTAEEALNSRWIKKY 308 >4LFI-A nrPDB Length = 374 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 67/245 (27%), Positives = 129/245 (52%), Gaps = 22/245 (8%) Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKY 156 H N+I + DI++ + V+ D ++ +++L + L++ I ++++++L+ L Y Sbjct: 132 HANIIHLFDIIKDPISKTPALVFEYVDNVD---FRILYPK-LTDLEIRFYMFELLKALDY 187 Query: 157 IHSANVLHRDLKPSNLLIN-TTCDLKICDFGLARIADPEHDHTGFLTEY---VATRWYRA 212 HS ++HRD+KP N++I+ L++ D+GLA E H EY VA+R+++ Sbjct: 188 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-----EFYHVNM--EYNVRVASRFFKG 240 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNC 271 PE++++ + Y S+D+WS G +LA M+ R P F G DQL I+ +LG+ E Sbjct: 241 PELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLL 300 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFP------KSDSKALDLLDRMLTFNPNKRITVEEAL 325 + + + W + + + +DL+D +L ++ +R+T +EA+ Sbjct: 301 KYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAM 360 Query: 326 AHPYL 330 HP+ Sbjct: 361 GHPWF 365 >2WO6-A nrPDB Length = 382 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 92/338 (27%), Positives = 155/338 (45%), Gaps = 54/338 (15%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQIL-LRFRHEN 99 RY IG+G++G V AYD V + VAIK I + + + E+++L L +H+ Sbjct: 55 RYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIK--NKKAFLNQAQIEVRLLELMNKHDT 112 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ---LSNDHICYFLYQILRGLKY 156 + + + +V +++ +LY LL++ +S + F Q+ L + Sbjct: 113 EMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLF 172 Query: 157 IHSA--NVLHRDLKPSNLLINT--TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 + + +++H DLKP N+L+ +KI DFG + + +Y+ +R+YR+ Sbjct: 173 LATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR------IYQYIQSRFYRS 226 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++L Y +ID+WS+GCIL EM + P+F G + +DQ+N I+ +LG P L+ Sbjct: 227 PEVLLGMP-YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQA 285 Query: 273 INMKARNYLQSLP------SKTKVAWAKLFPKSDSKA----------------------- 303 KAR + + LP KTK + P K Sbjct: 286 --PKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTV 343 Query: 304 ------LDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 DL+ RML ++P RI AL H + ++ D Sbjct: 344 ADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTAD 381 >4RGJ-A nrPDB Length = 520 Score = 103 bits (258), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 81/300 (27%), Positives = 140/300 (46%), Gaps = 44/300 (14%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP--FEHQTYCQRTLREIQILLRFR 96 +Y ++ +G+G++G V + D AIK IS + +T + LRE+++L Sbjct: 59 NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLD 118 Query: 97 HENVIGIRDILRASTLEAM-RDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLK 155 H N++ + + + + DVY +L + +++ ++ + QIL G+ Sbjct: 119 HINIMKLYEFFEDNNYYYLVSDVYTGGELFD----EIISRKRFYEIDAARIIKQILSGIT 174 Query: 156 YIHSANVLHRDLKPSNLLINTTCD----LKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 Y+H NV+HRDLKP N+L+ T +KI DFGL+ +++ + + + T +Y Sbjct: 175 YMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLS----THFEYSKKMKDKIGTAYYI 230 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 AP+++ + Y + DIWS G IL +LS P F G + D L + Sbjct: 231 APDVLHGT--YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV-------------- 274 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 +A Y LP F K KA DL+ +ML + RI+ +AL H +++ Sbjct: 275 ----EAGKYTFDLPQ---------FKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIK 321 >3RAW-A nrPDB Length = 381 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 93/335 (27%), Positives = 146/335 (43%), Gaps = 62/335 (18%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVR-KTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 RY + +GEG +G V DH R K++VA+K I Y + EI +L + + ++ Sbjct: 52 RYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNV--GKYREAARLEINVLKKIKEKD 109 Query: 100 VIG-IRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSN---DHICYFLYQILRGLK 155 +L + + I +L+ + ++ LK H+ + YQ+ L+ Sbjct: 110 KENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALR 169 Query: 156 YIHSANVLHRDLKPSNLLI-----------NTTCD--------LKICDFGLARIADPEHD 196 ++H + H DLKP N+L + +C+ +++ DFG A D EH Sbjct: 170 FLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF-DHEHH 228 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 T VATR YR PE++L G+ + D+WS+GCIL E +F + L Sbjct: 229 -----TTIVATRHYRPPEVIL-ELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVM 282 Query: 257 ILGILGS-PSQEDLNCIINMKARNYLQSLPSKTKVAWAK-----LFPKSDSKAL------ 304 + ILG PS +M R Q K + W + + K + K L Sbjct: 283 MEKILGPIPS--------HMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQ 334 Query: 305 ---------DLLDRMLTFNPNKRITVEEALAHPYL 330 DL+ RML F+P +RIT+ EAL HP+ Sbjct: 335 DSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 369 >6E2O-A nrPDB Length = 295 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 69/208 (33%), Positives = 107/208 (51%), Gaps = 22/208 (10%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G+G YG+V + D + R+AIK+I P Y Q EI + +H+N++ Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEI-PERDSRYSQPLHEEIALHKHLKHKNIV------ 82 Query: 108 RASTLEAMRDVYIVQDLMET----DLYKLLKSQ----QLSNDHICYFLYQILRGLKYIHS 159 L + + ++ ME L LL+S+ + + I ++ QIL GLKY+H Sbjct: 83 --QYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHD 140 Query: 160 ANVLHRDLKPSNLLINTTCD-LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 ++HRD+K N+LINT LKI DFG ++ + T + T Y APEI+ Sbjct: 141 NQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCT---ETFTGTLQYMAPEIIDK 197 Query: 219 S-KGYTKSIDIWSVGCILAEMLSNRPIF 245 +GY K+ DIWS+GC + EM + +P F Sbjct: 198 GPRGYGKAADIWSLGCTIIEMATGKPPF 225 >4FG9-A nrPDB Length = 320 Score = 101 bits (252), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 85/310 (27%), Positives = 140/310 (45%), Gaps = 58/310 (18%) Query: 39 GPRYTQLQYI----------GEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLRE 88 GPR+ Q + I G GA+ V A D + VAIK I+ + E Sbjct: 7 GPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENE 66 Query: 89 IQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLY-KLLKSQQLSNDHICYF 146 I +L + +H N++ + DI E+ +Y++ L+ +L+ ++++ + Sbjct: 67 IAVLHKIKHPNIVALDDIY-----ESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRL 121 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLL---INTTCDLKICDFGLARIADPEHDHTGFLTE 203 ++Q+L +KY+H ++HRDLKP NLL ++ + I DFGL+++ DP L+ Sbjct: 122 IFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDP----GSVLST 177 Query: 204 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI--- 260 T Y APE+ L K Y+K++D WS+G I +L P F ++ IL Sbjct: 178 ACGTPGYVAPEV-LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYE 236 Query: 261 LGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT 320 SP +D+ SDS A D + ++ +P KR T Sbjct: 237 FDSPYWDDI-----------------------------SDS-AKDFIRHLMEKDPEKRFT 266 Query: 321 VEEALAHPYL 330 E+AL HP++ Sbjct: 267 CEQALQHPWI 276 >5FG8-A nrPDB Length = 285 Score = 101 bits (252), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 87/296 (29%), Positives = 144/296 (48%), Gaps = 52/296 (17%) Query: 48 IGEGAYGMV------SSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 +G+GA+ +V S+ ++ K + KK++ + Q + RE +I + H N++ Sbjct: 22 LGKGAFSIVKRCVQKSTGFEFAAKI-INTKKLTARDFQ----KLEREARICRKLHHPNIV 76 Query: 102 GIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQL-SNDHICYFLYQILRGLKYIHS 159 + D ++ Y+V DL+ +L++ + +++ S + + QIL + + H Sbjct: 77 RLHDSIQEENYH-----YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQ 131 Query: 160 ANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 V+HRDLKP NLL+ + +K+ DFGLA + + DH + + T Y +PE+ Sbjct: 132 NGVVHRDLKPENLLLASKAKGAAVKLADFGLA--IEVQGDHQAWFG-FAGTPGYLSPEV- 187 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 L + Y KS+DIW+ G IL +L P F D+ H L +K Sbjct: 188 LKKEPYGKSVDIWACGVILYILLVGYPPF-----WDEDQHRL-------------YSQIK 229 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 A Y P W + P+ A +L+++MLT NPNKRIT EAL HP++ Q Sbjct: 230 AGAYDYPSPE-----WDTVTPE----AKNLINQMLTVNPNKRITAAEALKHPWICQ 276 >3BHH-A nrPDB Length = 295 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 89/302 (29%), Positives = 144/302 (47%), Gaps = 52/302 (17%) Query: 42 YTQLQYIGEGAYGMV------SSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95 Y + IG+GA+ +V + +++ K + KK+S +HQ + RE +I Sbjct: 6 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKI-INTKKLSARDHQ----KLEREARICRLL 60 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICYFLYQILRG 153 +H N++ + D + Y+V DL+ +L++ ++ + S + + QIL Sbjct: 61 KHSNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEA 115 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWY 210 + + H V+HRDLKP NLL+ + C +K+ DFGLA + + D + + T Y Sbjct: 116 VLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA--IEVQGDQQAWFG-FAGTPGY 172 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 +PE+ L + Y K +DIW+ G IL +L P F D+ H L Sbjct: 173 LSPEV-LRKEAYGKPVDIWACGVILYILLVGYPPF-----WDEDQHKL------------ 214 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 +KA Y PS W + P+ A +L+++MLT NP KRIT EAL HP++ Sbjct: 215 -YQQIKAGAY--DFPSPE---WDTVTPE----AKNLINQMLTINPAKRITAHEALKHPWV 264 Query: 331 EQ 332 Q Sbjct: 265 CQ 266 >2V7O-A nrPDB Length = 336 Score = 101 bits (251), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 90/305 (29%), Positives = 145/305 (47%), Gaps = 58/305 (19%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTR--------VAIKKISPFEHQTYCQRTLREIQILL 93 Y + +G+GA+ +V V+KT + KK+S +HQ + RE +I Sbjct: 33 YQLFEELGKGAFSVVRRC---VKKTPTQEYAAKIINTKKLSARDHQ----KLEREARICR 85 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICYFLYQIL 151 +H N++ + D + Y+V DL+ +L++ ++ + S + ++QIL Sbjct: 86 LLKHPNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADASHCIHQIL 140 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCD---LKICDFGLA-RIADPEHDHTGFLTEYVAT 207 + +IH +++HRDLKP NLL+ + C +K+ DFGLA + + GF T Sbjct: 141 ESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGF----AGT 196 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 Y +PE+ L Y K +DIW+ G IL +L P F D+ H L Sbjct: 197 PGYLSPEV-LRKDPYGKPVDIWACGVILYILLVGYPPF-----WDEDQHKL--------- 241 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAH 327 +KA Y PS W + P +A +L+++MLT NP KRIT ++AL H Sbjct: 242 ----YQQIKAGAY--DFPSPE---WDTVTP----EAKNLINQMLTINPAKRITADQALKH 288 Query: 328 PYLEQ 332 P++ Q Sbjct: 289 PWVCQ 293 >1U5R-A nrPDB Length = 348 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 91/335 (27%), Positives = 151/335 (45%), Gaps = 50/335 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQT--YCQRTLREIQILLRFRHEN 99 ++ L+ IG G++G V A D VAIKK+S Q+ Q ++E++ L + RH N Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 100 VIGIRDI-LRASTLEAMRDVYI--VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKY 156 I R LR T + + + DL+E + + L I + L+GL Y Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGSASDLLE------VHKKPLQEVEIAAVTHGALQGLAY 169 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 +HS N++HRD+K N+L++ +K+ DFG A I P + +V T ++ APE++ Sbjct: 170 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANS-------FVGTPYWMAPEVI 222 Query: 217 L--NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 L + Y +D+WS+G E+ +P + + L HI Sbjct: 223 LAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHI----------------- 265 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 334 A+N +L S W++ F + +D L P R T E L H ++ + Sbjct: 266 --AQNESPALQSGH---WSEYF-------RNFVDSCLQKIPQDRPTSEVLLKHRFVLRER 313 Query: 335 DPTD-EPVAEEPFTFAMELDDLPKERLKELIFQET 368 PT + + ELD+L ++K+++FQE Sbjct: 314 PPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEA 348 >4JG6-A nrPDB Length = 355 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 85/294 (28%), Positives = 141/294 (47%), Gaps = 47/294 (15%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF-RHENVIGIRDI 106 IG G+Y + A+K I + + EI+ILLR+ +H N+I ++D+ Sbjct: 43 IGVGSYSVCKRCIHKATNMEFAVKIIDKSK-----RDPTEEIEILLRYGQHPNIITLKDV 97 Query: 107 LRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLH 164 + + VY+V +LM+ L K+L+ + S L+ I + ++Y+H+ V+H Sbjct: 98 Y-----DDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVH 152 Query: 165 RDLKPSNLL-INTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 RDLKPSN+L ++ + + ++ICDFG A+ E+ G L T + APE+ L + Sbjct: 153 RDLKPSNILYVDESGNPESIRICDFGFAKQLRAEN---GLLMTPCYTANFVAPEV-LERQ 208 Query: 221 GYTKSIDIWSVGCILAEMLSN-RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN 279 GY + DIWS+G +L ML+ P G D IL +GS Sbjct: 209 GYDAACDIWSLGVLLYTMLTGYTPFANGPD--DTPEEILARIGS---------------- 250 Query: 280 YLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 K ++ SD+ A DL+ +ML +P++R+T L HP++ + Sbjct: 251 ------GKFSLSGGYWNSVSDT-AKDLVSKMLHVDPHQRLTAALVLRHPWIVHW 297 >3H4J-B nrPDB Length = 336 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 86/310 (27%), Positives = 141/310 (45%), Gaps = 50/310 (16%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP--FEHQTYCQRTLREIQILLRF 95 +GP Y + +GEG++G V A + + +VA+K IS + R REI L Sbjct: 8 IGP-YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLL 66 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYK-LLKSQQLSNDHICYFLYQILRGL 154 RH ++I + D++ T D+ +V + +L+ +++ ++++ D F QI+ + Sbjct: 67 RHPHIIKLYDVITTPT-----DIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAI 121 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 +Y H ++HRDLKP NLL++ ++KI DFGL+ I FL + Y APE Sbjct: 122 EYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIM----TDGNFLKTSCGSPNYAAPE 177 Query: 215 IMLNSKGYTK-SIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 + +N K Y +D+WS G +L ML R F + Sbjct: 178 V-INGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEF------------------------ 212 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY---- 329 N + + S V L P + S L+ RM+ +P +RIT++E P+ Sbjct: 213 ---IPNLFKKVNSCVYVMPDFLSPGAQS----LIRRMIVADPMQRITIQEIRRDPWFNVN 265 Query: 330 LEQYYDPTDE 339 L Y P +E Sbjct: 266 LPDYLRPMEE 275 >4APC-A nrPDB Length = 350 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 67/220 (30%), Positives = 113/220 (51%), Gaps = 24/220 (10%) Query: 36 FDVGPRYTQLQYIGEGAYG---MVSSAYD---HVRKTRVAIKKISPFEHQTYCQRTLREI 89 F +Y +LQ IGEG++G +V S D +V K + I ++S E + + RE+ Sbjct: 20 FQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIK-EINISRMSSKERE----ESRREV 74 Query: 90 QILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ---LSNDHICY 145 +L +H N++ R+ + E +YIV D E DL+K + +Q+ D I Sbjct: 75 AVLANMKHPNIVQYRE-----SFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILD 129 Query: 146 FLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYV 205 + QI LK++H +LHRD+K N+ + +++ DFG+AR+ + + + Sbjct: 130 WFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVE---LARACI 186 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 T +Y +PEI N K Y DIW++GC+L E+ + + F Sbjct: 187 GTPYYLSPEICEN-KPYNNKSDIWALGCVLYELCTLKHAF 225 >2GCD-A nrPDB Length = 309 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 91/335 (27%), Positives = 151/335 (45%), Gaps = 50/335 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQT--YCQRTLREIQILLRFRHEN 99 ++ L+ IG G++G V A D VAIKK+S Q+ Q ++E++ L + RH N Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 100 VIGIRDI-LRASTLEAMRDVYI--VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKY 156 I R LR T + + + DL+E + + L I + L+GL Y Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSASDLLE------VHKKPLQEVEIAAVTHGALQGLAY 130 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 +HS N++HRD+K N+L++ +K+ DFG A I P + +V T ++ APE++ Sbjct: 131 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANS-------FVGTPYWMAPEVI 183 Query: 217 L--NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 L + Y +D+WS+G E+ +P + + L HI Sbjct: 184 LAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHI----------------- 226 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 334 A+N +L S W++ F + +D L P R T E L H ++ + Sbjct: 227 --AQNESPALQSGH---WSEYFR-------NFVDSCLQKIPQDRPTSEVLLKHRFVLRER 274 Query: 335 DPTD-EPVAEEPFTFAMELDDLPKERLKELIFQET 368 PT + + ELD+L ++K+++FQE Sbjct: 275 PPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEA 309 >2Y7J-A nrPDB Length = 365 Score = 97.8 bits (242), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 81/310 (26%), Positives = 138/310 (44%), Gaps = 57/310 (18%) Query: 41 RYTQLQYIGEGAYGMVSS----AYDH---VRKTRVAIKKISPFEHQTYCQRTLREIQILL 93 +Y IG G +V A H V+ V +++SP + + + T RE IL Sbjct: 95 KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILR 154 Query: 94 RFR-HENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQ-QLSNDHICYFLYQI 150 + H ++I + D +S+ +++V DLM + +L+ L + LS + + Sbjct: 155 QVAGHPHIITLIDSYESSSF-----MFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSL 209 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY 210 L + ++H+ N++HRDLKP N+L++ +++ DFG + +P L E T Y Sbjct: 210 LEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEK----LRELCGTPGY 265 Query: 211 RAPEIMLNSK-----GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG---ILG 262 APEI+ S GY K +D+W+ G IL +L+ P F + + L I+ Sbjct: 266 LAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFS 325 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVE 322 SP +D + + DL+ R+L +P R+T E Sbjct: 326 SPEWDDRSSTVK------------------------------DLISRLLQVDPEARLTAE 355 Query: 323 EALAHPYLEQ 332 +AL HP+ E+ Sbjct: 356 QALQHPFFER 365 >6FD3-A nrPDB Length = 300 Score = 97.8 bits (242), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 72/295 (24%), Positives = 133/295 (45%), Gaps = 37/295 (12%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 D +YT+ + IG+GA G V +A D VAIK+++ + Q + + EI ++ + Sbjct: 19 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN-LQQQPKKELIINEILVMRENK 77 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKY 156 + N++ D S L +++ L L ++ + I + L+ L + Sbjct: 78 NPNIVNYLD----SYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDF 133 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 +HS V+HRD+K N+L+ +K+ DFG PE + V T ++ APE+ Sbjct: 134 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM---VGTPYWMAPEV- 189 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + K Y +DIWS+G + EM+ P + ++ L L +++ G+P ++ Sbjct: 190 VTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTPELQN-------- 240 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 P + + D L+R L + ++R + +E L HP+L+ Sbjct: 241 --------PERLSAVFR-----------DFLNRCLEMDVDRRGSAKELLQHPFLK 276 >2BDW-A nrPDB Length = 362 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 86/296 (29%), Positives = 139/296 (46%), Gaps = 45/296 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY-CQRTLREIQILLRFRHENV 100 Y + +G+GA+ +V A K I+ + Q+ RE +I + +H N+ Sbjct: 31 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 90 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQL-SNDHICYFLYQILRGLKYIH 158 + + D ++ + Y+V DL+ +L++ + +++ S + + QIL + Y H Sbjct: 91 VRLHDSIQEESFH-----YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCH 145 Query: 159 SANVLHRDLKPSNLLINTTCD---LKICDFGLA-RIADPEHDHTGFLTEYVATRWYRAPE 214 S ++HR+LKP NLL+ + +K+ DFGLA + D E H GF T Y +PE Sbjct: 146 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWH-GF----AGTPGYLSPE 200 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 + L Y+K +DIW+ G IL +L P F D+ H L Sbjct: 201 V-LKKDPYSKPVDIWACGVILYILLVGYPPF-----WDEDQHRL-------------YAQ 241 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 +KA Y P W + P++ S L+D MLT NP KRIT ++AL P++ Sbjct: 242 IKAGAYDYPSPE-----WDTVTPEAKS----LIDSMLTVNPKKRITADQALKVPWI 288 >4I6B-A nrPDB Length = 308 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 83/307 (27%), Positives = 141/307 (45%), Gaps = 52/307 (16%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-----HQTYCQRTLREIQIL 92 G RY++ + +G+G + D + +V KI P HQ ++ +EI++ Sbjct: 26 TGKRYSRGKTLGKGGFAKCYEMTD-LTNNKVYAAKIIPHSRVSKPHQR--EKIDKEIELH 82 Query: 93 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQI 150 H++V+ E ++YI+ + + +LK+++ L+ + Y+L QI Sbjct: 83 RILHHKHVVQF-----YHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQI 137 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADP-EHDHTGFLTEYVATRW 209 + GLKY+H +LHRDLK N IN + +LK+ DFGLA +P EH T Sbjct: 138 VSGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTI----CGTPN 193 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 269 Y +PE+ LN +G+ DIW++GC++ ML RP F + + I Sbjct: 194 YLSPEV-LNKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSI------------ 240 Query: 270 NCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY 329 R ++PS + +A AK L+ ML+ NP R ++++ + H + Sbjct: 241 --------REARYTMPS-SLLAPAK----------HLIASMLSKNPEDRPSLDDIIRHDF 281 Query: 330 LEQYYDP 336 Q + P Sbjct: 282 FTQGFTP 288 >5JZN-A nrPDB Length = 280 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 85/302 (28%), Positives = 137/302 (45%), Gaps = 43/302 (14%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 P + RY + IG+G + +V + A+K I + + E+ IL R Sbjct: 14 PATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRR 73 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKS-QQLSNDHICYFLYQILR 152 +H N++ L ++ ++Y+V +L++ DL+ + S + + LY + Sbjct: 74 VKHPNIV-----LLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLAS 128 Query: 153 GLKYIHSANVLHRDLKPSNLLI----NTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 +KY+HS N++HRD+KP NLL+ + + LK+ DFGLA I D G L T Sbjct: 129 AIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVD------GPLYTVCGTP 182 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 Y APEI+ + GY +DIW+ G I +L P F G QE Sbjct: 183 TYVAPEIIAET-GYGLKVDIWAAGVITYILLCGFPPFRGS--------------GDDQEV 227 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 328 L I M ++ PS W + SDS A +L+ ML + ++R + + L HP Sbjct: 228 LFDQILMGQVDF----PSP---YWDNV---SDS-AKELITMMLLVDVDQRFSAVQVLEHP 276 Query: 329 YL 330 ++ Sbjct: 277 WV 278 >6QAU-A nrPDB Length = 280 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 91/306 (29%), Positives = 149/306 (48%), Gaps = 56/306 (18%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKT--RVAIKKISPFEHQTYCQRTL-REIQILLRFRHE 98 Y++ +G GA+ +V H +KT VAIK I+ ++ + Q L +EI+IL +HE Sbjct: 13 YSKRDLVGHGAFAVVFRG-RHRQKTDWEVAIKSINK-KNLSKSQILLGKEIKILKELQHE 70 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ-QLSNDHICYFLYQILRGLKY 156 N++ + D+ E V++V + DL L+++ LS D I FL+QI ++ Sbjct: 71 NIVALYDVQ-----ELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRI 125 Query: 157 IHSANVLHRDLKPSNLLIN---------TTCDLKICDFGLARIADPEHDHTGFL-TEYVA 206 +HS ++HRDLKP N+L++ + +KI DFG AR + H+ + + Sbjct: 126 LHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFAR-----YLHSNMMAADLCG 180 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 + Y APE+++ S+ Y D+WS+G ++ + L +P F Q N S Sbjct: 181 SPMYMAPEVIM-SQHYDAKADLWSIGTVIYQCLVGKPPF-------QAN---------SP 223 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 +DL K R+ + S+P +T P + L LL R N R+ E + Sbjct: 224 QDLRMFYE-KNRSLMPSIPRETS-------PYLANLLLGLLQR----NQKDRMDFEAFFS 271 Query: 327 HPYLEQ 332 HP+LEQ Sbjct: 272 HPFLEQ 277 >6CMJ-A nrPDB Length = 321 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 78/306 (25%), Positives = 146/306 (47%), Gaps = 48/306 (15%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP----------FEHQTYCQRTLREIQ 90 +YT IG+G+YG+V AY+ T A+K +S + + ++ +EI Sbjct: 35 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIA 94 Query: 91 ILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQLSNDHICYFLYQ 149 IL + H NV+ + ++L + + Y+V +L+ + + ++ + LS D ++ Sbjct: 95 ILKKLDHPNVVKLVEVLDDPNEDHL---YMVFELVNQGPVMEVPTLKPLSEDQARFYFQD 151 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW 209 +++G++Y+H ++HRD+KPSNLL+ +KI DFG +++ L+ V T Sbjct: 152 LIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFG---VSNEFKGSDALLSNTVGTPA 208 Query: 210 YRAPEIMLNSKGY--TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 + APE + ++ K++D+W++G L +F ++D E Sbjct: 209 FMAPESLSETRKIFSGKALDVWAMGVTLYCF-----VFGQCPFMD--------------E 249 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAH 327 + C ++ K ++ P + +A D K DL+ RML NP RI V E H Sbjct: 250 RIMC-LHSKIKSQALEFPDQPDIA-------EDLK--DLITRMLDKNPESRIVVPEIKLH 299 Query: 328 PYLEQY 333 P++ ++ Sbjct: 300 PWVTRH 305 >3KK8-A nrPDB Length = 284 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 86/296 (29%), Positives = 139/296 (46%), Gaps = 45/296 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY-CQRTLREIQILLRFRHENV 100 Y + +G+GA+ +V A K I+ + Q+ RE +I + +H N+ Sbjct: 8 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 67 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQL-SNDHICYFLYQILRGLKYIH 158 + + D ++ + Y+V DL+ +L++ + +++ S + + QIL + Y H Sbjct: 68 VRLHDSIQEESFH-----YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCH 122 Query: 159 SANVLHRDLKPSNLLINTTCD---LKICDFGLA-RIADPEHDHTGFLTEYVATRWYRAPE 214 S ++HR+LKP NLL+ + +K+ DFGLA + D E H GF T Y +PE Sbjct: 123 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWH-GF----AGTPGYLSPE 177 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 + L Y+K +DIW+ G IL +L P F D+ H L Sbjct: 178 V-LKKDPYSKPVDIWACGVILYILLVGYPPF-----WDEDQHRL-------------YAQ 218 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 +KA Y P W + P++ S L+D MLT NP KRIT ++AL P++ Sbjct: 219 IKAGAYDYPSPE-----WDTVTPEAKS----LIDSMLTVNPKKRITADQALKVPWI 265 >2BRG-A nrPDB Length = 297 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 82/285 (28%), Positives = 129/285 (45%), Gaps = 42/285 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-EIQILLRFRHENV 100 + +Q +GEGAYG V A + V + VA+K I + C ++ EI I HENV Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVK-IVDMKRAVDCPENIKKEICINKMLNHENV 67 Query: 101 IGIRDILRASTLEAMRDVYI----VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKY 156 + R ++ + Y + D +E D+ Q F +Q++ G+ Y Sbjct: 68 VKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQ-------RFFHQLMAGVVY 120 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 +H + HRD+KP NLL++ +LKI DFGLA + ++ L + T Y APE++ Sbjct: 121 LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFR-YNNRERLLNKMCGTLPYVAPELL 179 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + + + +D+WS G +L ML+ G+ DQ PS + Sbjct: 180 KRREFHAEPVDVWSCGIVLTAMLA------GELPWDQ----------PSDSCQEYSDWKE 223 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 321 + YL W K+ DS L LL ++L NP+ RIT+ Sbjct: 224 KKTYLN--------PWKKI----DSAPLALLHKILVENPSARITI 256 >2F57-A nrPDB Length = 317 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 74/291 (25%), Positives = 131/291 (45%), Gaps = 39/291 (13%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 IGEG+ G+V A + +VA+KK+ Q + E+ I+ + H+NV+ + Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMD-LRKQQRRELLFNEVVIMRDYHHDNVVDM---- 107 Query: 108 RASTLEAMRDVYIVQDLMETD-LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRD 166 S+ ++++V + +E L ++ +++ + I +LR L Y+H+ V+HRD Sbjct: 108 -YSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRD 166 Query: 167 LKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSI 226 +K ++L+ + +K+ DFG E L V T ++ APE+ ++ Y + Sbjct: 167 IKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSL---VGTPYWMAPEV-ISRLPYGTEV 222 Query: 227 DIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPS 286 DIWS+G ++ EM+ P + + L + R SLP Sbjct: 223 DIWSLGIMVIEMIDGEPPYFNEPPLQAM-----------------------RRIRDSLPP 259 Query: 287 KTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 + K K S LD ML P++R T +E L HP+L+ P+ Sbjct: 260 RVKD-----LHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPS 305 >3IS5-A nrPDB Length = 285 Score = 94.7 bits (234), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 81/294 (27%), Positives = 130/294 (44%), Gaps = 48/294 (16%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G GA+G V + IK I+ Q ++ EI++L H N+I I ++ Sbjct: 30 LGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHPNIIKIFEVF 89 Query: 108 RASTLEAMRDVYIVQD------LMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSAN 161 E ++YIV + L+E + + + LS ++ + Q++ L Y HS + Sbjct: 90 -----EDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHSQH 144 Query: 162 VLHRDLKPSNLLINTT---CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 V+H+DLKP N+L T +KI DFGLA + + +H+ T T Y APE+ Sbjct: 145 VVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSD-EHS---TNAAGTALYMAPEVF-- 198 Query: 219 SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKAR 278 + T DIWS G ++ +L+ F G S E++ K Sbjct: 199 KRDVTFKCDIWSAGVVMYFLLTGCLPFTGT----------------SLEEVQQKATYKEP 242 Query: 279 NYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 NY V L P +A+DLL +MLT +P +R + + L H + +Q Sbjct: 243 NY--------AVECRPLTP----QAVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >4YZB-A nrPDB Length = 491 Score = 94.4 bits (233), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 79/304 (25%), Positives = 140/304 (46%), Gaps = 43/304 (14%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP--FEHQTYCQRTLREIQILLRFRHE 98 RY + +G+G++G V D V A+K IS + +T + L+E+++L + H Sbjct: 31 RYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHP 90 Query: 99 NVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYI 157 N++ + + + +VY +L + +++ ++ S + Q+L G+ Y+ Sbjct: 91 NIMKLYEFFEDKGYFYLVTEVYTGGELFD----EIISRKRFSEVDAARIIRQVLSGITYM 146 Query: 158 HSANVLHRDLKPSNLLINTT---CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 H ++HRDLKP NLL+ +++I DFGL+ + T + + + T +Y APE Sbjct: 147 HKNKIVHRDLKPENLLLENKRKDANIRIIDFGLS----THFESTKKMKDKIGTAYYIAPE 202 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 ++ + Y + D+WS G IL +LS P F G + D L + Sbjct: 203 VLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKV----------------- 243 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 334 + + LP KV+ A DL+ +ML + P RI+ +AL H +L+ Sbjct: 244 -EKGKFTFDLPQWKKVS---------EPAKDLIRKMLAYVPTMRISARDALEHEWLKTTD 293 Query: 335 DPTD 338 TD Sbjct: 294 AATD 297 >3Q53-A nrPDB Length = 306 Score = 94.4 bits (233), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 71/295 (24%), Positives = 132/295 (44%), Gaps = 37/295 (12%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 D +YT+ + IG+GA G V +A D VAI++++ + Q + + EI ++ + Sbjct: 18 DPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN-LQQQPKKELIINEILVMRENK 76 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKY 156 + N++ D S L +++ L L ++ + I + L+ L++ Sbjct: 77 NPNIVNYLD----SYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEF 132 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 +HS V+HRD+K N+L+ +K+ DFG PE + V T ++ APE+ Sbjct: 133 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM---VGTPYWMAPEV- 188 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + K Y +DIWS+G + EM+ P + ++ L L +++ G+P ++ Sbjct: 189 VTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRAL-YLIATNGTPELQN-------- 239 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 P K + D L+R L + KR + +E + H +L+ Sbjct: 240 --------PEKLSAIFR-----------DFLNRCLEMDVEKRGSAKELIQHQFLK 275 >3MN3-A nrPDB Length = 271 Score = 94.4 bits (233), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 79/303 (26%), Positives = 128/303 (42%), Gaps = 45/303 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP--FEHQTYCQRTLREIQILLRFRHEN 99 Y ++ +GEG++G V AY +VA+K I+ R REI L RH + Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 65 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159 +I + D++++ M Y +L + +++ ++S F QI+ ++Y H Sbjct: 66 IIKLYDVIKSKDEIIMVIEYAGNELFDY----IVQRDKMSEQEARRFFQQIISAVEYCHR 121 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 ++HRDLKP NLL++ ++KI DFGL+ I FL + Y APE++ Sbjct: 122 HKIVHRDLKPENLLLDEHLNVKIADFGLSNIM----TDGNFLKTSCGSPNYAAPEVISGK 177 Query: 220 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN 279 +D+WS G IL ML R P ++ ++ N Sbjct: 178 LYAGPEVDVWSCGVILYVMLCRR--------------------LPFDDESIPVLFKNISN 217 Query: 280 YLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY----LEQYYD 335 + +LP A L+ RML NP RI++ E + + L +Y Sbjct: 218 GVYTLPKFLSPG-----------AAGLIKRMLIVNPLNRISIHEIMQDDWFKVDLPEYLL 266 Query: 336 PTD 338 P D Sbjct: 267 PPD 269 >6FDY-U nrPDB Length = 276 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 78/297 (26%), Positives = 140/297 (47%), Gaps = 46/297 (15%) Query: 48 IGEGAYGMVSSAYDHVRKTR--VAIKKISPFE-HQTYCQRTLREIQILLRFRHENVIGIR 104 +G G Y V AY + TR VAIK ++ ++ + L EI+IL RH +++ ++ Sbjct: 19 LGSGTYATVYKAYAK-KDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLK 77 Query: 105 DILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDHIC-YFLYQILRGLKYIHSANV 162 D S ++Y++ + DL + + ++++ + + F+ Q+ L+++H N+ Sbjct: 78 DFQWDSD-----NIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNI 132 Query: 163 LHRDLKPSNLLINT--TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 H DLKP N+L+++ LK+ DFG A+ P D L + Y APE M+ + Sbjct: 133 SHLDLKPQNILLSSLEKPHLKLADFGFAQHMSP-WDEKHVLR---GSPLYMAPE-MVCQR 187 Query: 221 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNY 280 Y +D+WS+G IL E L +P F + + + I N +I + R Sbjct: 188 QYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRS----------NRVIELPLR-- 235 Query: 281 LQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 P DLL R+L +P++RI+ ++ AHP+++ + P+ Sbjct: 236 ----------------PLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPS 276 >2VN9-A nrPDB Length = 301 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 86/302 (28%), Positives = 141/302 (46%), Gaps = 52/302 (17%) Query: 42 YTQLQYIGEGAYGMVS------SAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95 Y + +G+GA+ +V + ++ K + KK+S +HQ + RE +I Sbjct: 6 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKI-INTKKLSARDHQ----KLEREARICRLL 60 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICYFLYQILRG 153 +H N++ + D + Y+V DL+ +L++ ++ + S + + QIL Sbjct: 61 KHPNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILES 115 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWY 210 + + H ++HRDLKP NLL+ + +K+ DFGLA + + D + + T Y Sbjct: 116 VNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA--IEVQGDQQAWFG-FAGTPGY 172 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 +PE+ L Y K +D+W+ G IL +L P F D+ H L Sbjct: 173 LSPEV-LRKDPYGKPVDMWACGVILYILLVGYPPF-----WDEDQHRL------------ 214 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 +KA Y PS W + P+ A DL+++MLT NP KRIT EAL HP++ Sbjct: 215 -YQQIKAGAY--DFPSPE---WDTVTPE----AKDLINKMLTINPAKRITASEALKHPWI 264 Query: 331 EQ 332 Q Sbjct: 265 CQ 266 >3F3Z-A nrPDB Length = 277 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 82/301 (27%), Positives = 133/301 (44%), Gaps = 44/301 (14%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 D+ YT IG G++G V A + R A KKI + + R +EI+I+ Sbjct: 6 DINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVED-VDRFKQEIEIMKSLD 64 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMET-DLY-KLLKSQQLSNDHICYFLYQILRGL 154 H N+I + + T E D+Y+V +L +L+ +++ + + +L + Sbjct: 65 HPNIIRLYE-----TFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAV 119 Query: 155 KYIHSANVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 Y H NV HRDLKP N L T LK+ DFGLA P + V T +Y Sbjct: 120 AYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGK----MMRTKVGTPYYV 175 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 +P+++ Y D WS G ++ +L P F +P+ + Sbjct: 176 SPQVL--EGLYGPECDEWSAGVMMYVLLCGYPPF----------------SAPTDSE--- 214 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + +K R + P K W + P+++S L+ R+LT +P +RIT +AL H + E Sbjct: 215 -VMLKIREGTFTFPEKD---WLNVSPQAES----LIRRLLTKSPKQRITSLQALEHEWFE 266 Query: 332 Q 332 + Sbjct: 267 K 267 >5XZW-A nrPDB Length = 471 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 79/301 (26%), Positives = 129/301 (42%), Gaps = 52/301 (17%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 + +G+GA+ V A + A+K IS + RE+++L + H ++ ++ Sbjct: 202 EVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKG 261 Query: 106 ILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ-QLSNDHICYFLYQILRGLKYIHSANVL 163 E Y+V + + DL + + + D QIL +KYIHS + Sbjct: 262 FY-----EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGIS 316 Query: 164 HRDLKPSNLLI--NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKG 221 HRDLKP N+LI + +KI DFGLA++ + F+ + T Y APE++ Sbjct: 317 HRDLKPDNILIEQDDPVLVKITDFGLAKV----QGNGSFMKTFCGTLAYVAPEVIRGKDT 372 Query: 222 ------------YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 269 Y+ +D+WS+GC++ +L+ F G DQL +G Sbjct: 373 SVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQLYKQIG---------- 421 Query: 270 NCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY 329 R P K F S+ +A D +D +L +PN R T +AL HP+ Sbjct: 422 --------RGSYHEGPLKD-------FRISE-EARDFIDSLLQVDPNNRSTAAKALNHPW 465 Query: 330 L 330 + Sbjct: 466 I 466 >2JAM-A nrPDB Length = 304 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 77/308 (25%), Positives = 138/308 (44%), Gaps = 54/308 (17%) Query: 34 QPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIK--KISPFEHQTYCQRTLREIQI 91 Q ++ + ++ +G GA+ V + A+K K SP + + EI + Sbjct: 3 QTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLEN---EIAV 59 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLY-KLLKSQQLSNDHICYFLYQ 149 L + +HEN++ + DI ++T Y+V L+ +L+ ++L+ + + Q Sbjct: 60 LKKIKHENIVTLEDIYESTT-----HYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQ 114 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVA 206 +L +KY+H ++HRDLKP NLL T + I DFGL+++ + G ++ Sbjct: 115 VLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM-----EQNGIMSTACG 169 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF---PGKHYLDQLNHILGILGS 263 T Y APE+ L K Y+K++D WS+G I +L P F +++ S Sbjct: 170 TPGYVAPEV-LAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES 228 Query: 264 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEE 323 P +D++ A D + +L +PN+R T E+ Sbjct: 229 PFWDDIS------------------------------ESAKDFICHLLEKDPNERYTCEK 258 Query: 324 ALAHPYLE 331 AL+HP+++ Sbjct: 259 ALSHPWID 266 >4B6L-A nrPDB Length = 281 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 83/311 (26%), Positives = 137/311 (44%), Gaps = 50/311 (16%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE----HQTYCQRTLREIQILLR 94 G Y + + +G+G + A D + A+K I HQ ++ L EI++ Sbjct: 8 GRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQR--EKILNEIELHRD 65 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ-LSNDHICYFLYQILR 152 +H +++ + E ++YI +L L + K++ L + Y+L QIL Sbjct: 66 LQHRHIVRF-----SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILS 120 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGL-ARIADPEHDHTGFLTEYVATRWYR 211 GLKY+H +LHRDLK N I +LK+ DFGL AR+ PE T Y Sbjct: 121 GLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTI----CGTPNYV 176 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 APE++L +G+ D+WS+GC++ +L P F + +E C Sbjct: 177 APEVLLR-QGHGPEADVWSLGCVMYTLLCGSPPFE---------------TADLKETYRC 220 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 I K +Y +LP+ + A LL +L +P R ++++ L H + Sbjct: 221 I---KQVHY--TLPASLSLP-----------ARQLLAAILRASPRDRPSIDQILRHDFFT 264 Query: 332 QYYDPTDEPVA 342 + Y P P++ Sbjct: 265 KGYTPDRLPIS 275 >2VZ6-A nrPDB Length = 313 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 85/301 (28%), Positives = 139/301 (46%), Gaps = 50/301 (16%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVA-----IKKISPFEHQTYCQRTLREIQILLRFR 96 Y + +G+GA+ +V + A KK+S +HQ + RE +I + Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQ----KLEREARICRLLK 79 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICYFLYQILRGL 154 H N++ + D ++ Y++ DL+ +L++ ++ + S + + QIL + Sbjct: 80 HPNIVRLHD-----SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAV 134 Query: 155 KYIHSANVLHRDLKPSNLLINTT---CDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 + H V+HRDLKP NLL+ + +K+ DFGLA + E + + + T Y Sbjct: 135 LHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA--IEVEGEQQAWFG-FAGTPGYL 191 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 +PE+ L Y K +D+W+ G IL +L P F D+ H L Sbjct: 192 SPEV-LRKDPYGKPVDLWACGVILYILLVGYPPF-----WDEDQHRL------------- 232 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 +KA Y PS W + P+ A DL+++MLT NP+KRIT EAL HP++ Sbjct: 233 YQQIKAGAY--DFPSPE---WDTVTPE----AKDLINKMLTINPSKRITAAEALKHPWIS 283 Query: 332 Q 332 Sbjct: 284 H 284 >5U6Y-A nrPDB Length = 461 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 85/300 (28%), Positives = 142/300 (47%), Gaps = 52/300 (17%) Query: 42 YTQLQYIGEGAYGMVS------SAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95 Y + +G+GA+ +V + ++ K + KK+S +HQ + RE +I Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKI-INTKKLSARDHQ----KLEREARICRLL 56 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICYFLYQILRG 153 +H N++ + D ++ Y++ DL+ +L++ ++ + S + + QIL Sbjct: 57 KHPNIVRLHD-----SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEA 111 Query: 154 LKYIHSANVLHRDLKPSNLLINTT---CDLKICDFGLARIADPEHDHTGFLTEYVATRWY 210 + + H V+HRDLKP NLL+ + +K+ DFGLA + E + + + T Y Sbjct: 112 VLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA--IEVEGEQQAWFG-FAGTPGY 168 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 +PE+ L Y K +D+W+ G IL +L P F D+ H L Sbjct: 169 LSPEV-LRKDPYGKPVDLWACGVILYILLVGYPPF-----WDEDQHRL------------ 210 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 +KA Y PS W + P+ A DL+++MLT NP+KRIT EAL HP++ Sbjct: 211 -YQQIKAGAY--DFPSPE---WDTVTPE----AKDLINKMLTINPSKRITAAEALKHPWI 260 >3DAK-A nrPDB Length = 290 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 62/212 (29%), Positives = 102/212 (48%), Gaps = 17/212 (8%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 Y + IG GA +V +AY +K +VAIK+I+ + QT L+EIQ + + H N++ Sbjct: 12 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 71 Query: 102 GIRDILRASTLEAMRDVYIVQDLME----TDLYKLL------KSQQLSNDHICYFLYQIL 151 ++ ++++V L+ D+ K + KS L I L ++L Sbjct: 72 SYY-----TSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVL 126 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHT--GFLTEYVATRW 209 GL+Y+H +HRD+K N+L+ ++I DFG++ D T +V T Sbjct: 127 EGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPC 186 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN 241 + APE+M +GY DIWS G E+ + Sbjct: 187 WMAPEVMEQVRGYDFKADIWSFGITAIELATG 218 >4CZT-A nrPDB Length = 464 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 81/298 (27%), Positives = 132/298 (44%), Gaps = 41/298 (13%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFRHE 98 +Y + +GEG + V A + VAIK I + + REI + +H Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 71 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLKYI 157 NVI + +++ + T + ++++ + +L+ K+ + +L D + Q++ + Y Sbjct: 72 NVIRMFEVMASKT----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 127 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 HS V HRDLKP NLL++ LK+ DFGL+ + + G L T Y APE+ + Sbjct: 128 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVRED-GLLHTTCGTPNYVAPEV-I 185 Query: 218 NSKGYTKS-IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 N+KGY + D+WS G IL +++ F ED N Sbjct: 186 NNKGYDGAKADLWSCGVILFVLMAGYLPF---------------------EDSN------ 218 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 334 L SL K A P + A L+ R+L NP RIT E + + + ++ Y Sbjct: 219 ----LTSLYKKIFKAEFTCPPWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGY 272 >4EQM-A nrPDB Length = 294 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 66/216 (30%), Positives = 108/216 (50%), Gaps = 14/216 (6%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILLRF 95 + RY + +G G V A D + +VAIK I P E + +R RE+ + Sbjct: 9 INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQL 68 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRG 153 H+N++ + D+ Y+V + +E L + ++S LS D F QIL G Sbjct: 69 SHQNIVSMIDVDEEDDC-----YYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDG 123 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRA 212 +K+ H ++HRD+KP N+LI++ LKI DFG+A+ +++ T + + T Y + Sbjct: 124 IKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHV---LGTVQYFS 180 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 248 PE + + DI+S+G +L EML P F G+ Sbjct: 181 PE-QAKGEATDECTDIYSIGIVLYEMLVGEPPFNGE 215 >4PDS-A nrPDB Length = 347 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 77/302 (25%), Positives = 129/302 (42%), Gaps = 52/302 (17%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 + +G+GA+ V A + ++K IS + RE+++L + H ++ ++ Sbjct: 37 EVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKG 96 Query: 106 ILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ-QLSNDHICYFLYQILRGLKYIHSANVL 163 E Y+V + + DL + + + D QIL +KYIHS + Sbjct: 97 FY-----EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGIS 151 Query: 164 HRDLKPSNLLI--NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKG 221 HRDLKP N+LI + +KI FGLA++ + F+ + T Y APE++ Sbjct: 152 HRDLKPDNILIEQDDPVLVKITAFGLAKV----QGNGSFMKTFCGTLAYVAPEVIRGKDT 207 Query: 222 ------------YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 269 Y+ +D+WS+GC++ +L+ F G DQL +G Sbjct: 208 SVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQLYKQIG---------- 256 Query: 270 NCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY 329 R P K F S+ +A D +D +L +PN R T +AL HP+ Sbjct: 257 --------RGSYHEGPLKD-------FRISE-EARDFIDSLLQVDPNNRSTAAKALNHPW 300 Query: 330 LE 331 ++ Sbjct: 301 IK 302 >3VN9-A nrPDB Length = 340 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 83/299 (27%), Positives = 134/299 (44%), Gaps = 59/299 (19%) Query: 48 IGEGAYGMVSSAYDHVRKTRV-AIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDI 106 +G GAYG+V HV ++ A+K+I + +R L ++ I +R V + Sbjct: 59 LGRGAYGVVEKMR-HVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR----TVDCPFTV 113 Query: 107 LRASTLEAMRDVYIVQDLMETDLYKLLK-----SQQLSNDHICYFLYQILRGLKYIHSA- 160 L DV+I +LM+T L K K Q + D + I++ L+++HS Sbjct: 114 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 Query: 161 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA------TRWYRAPE 214 +V+HRD+KPSN+LIN +K+CDFG+ +G+L + VA + Y APE Sbjct: 174 SVIHRDVKPSNVLINALGQVKMCDFGI----------SGYLVDSVAKTIDAGCKPYMAPE 223 Query: 215 IM---LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 + LN KGY+ DIWS+G + E+ R FP + + ++ PS + Sbjct: 224 RINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSPQ---- 277 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 LP+ K ++ +D + L N +R T E + HP+ Sbjct: 278 ------------LPAD----------KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 >2WTK-C nrPDB Length = 305 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 79/313 (25%), Positives = 134/313 (42%), Gaps = 44/313 (14%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ---RTLREIQILLRFRH 97 +Y +GEG+YG V D R A+K + + + +EIQ+L R RH Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICY---FLYQILRGL 154 +NVI + D+L E + +Y+V + + ++L S +C + Q++ GL Sbjct: 66 KNVIQLVDVLYN---EEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGL 122 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADP-EHDHTGFLTEYVATRWYRAP 213 +Y+HS ++H+D+KP NLL+ T LKI G+A P D T ++ + ++ P Sbjct: 123 EYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQ--GSPAFQPP 180 Query: 214 EIMLNSKGYTK-SIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 EI ++ +DIWS G L + + F G D + + +G S Sbjct: 181 EIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEG----DNIYKLFENIGKGS------- 229 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 ++P + DLL ML + P KR ++ + H + + Sbjct: 230 ---------YAIPGDCGPPLS-----------DLLKGMLEYEPAKRFSIRQIRQHSWFRK 269 Query: 333 YYDPTDEPVAEEP 345 + P + PV P Sbjct: 270 KHPPAEAPVPIPP 282 >5YV8-A nrPDB Length = 298 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 78/318 (24%), Positives = 144/318 (45%), Gaps = 63/318 (19%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP------------------------- 75 +YT IG+G+YG+V AY+ T A+K +S Sbjct: 14 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGC 73 Query: 76 FEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLK 134 + + ++ +EI IL + H NV+ + ++L + + Y+V +L+ + + ++ Sbjct: 74 IQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHL---YMVFELVNQGPVMEVPT 130 Query: 135 SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPE 194 + LS D ++ +++G++Y+H ++HRD+KPSNLL+ +KI DFG +++ Sbjct: 131 LKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFG---VSNEF 187 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGY--TKSIDIWSVGCILAEMLSNRPIFPGKHYLD 252 L+ V T + APE + ++ K++D+W++G L +F ++D Sbjct: 188 KGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCF-----VFGQCPFMD 242 Query: 253 QLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLT 312 E + C ++ K ++ P + +A D K DL+ RML Sbjct: 243 --------------ERIMC-LHSKIKSQALEFPDQPDIA-------EDLK--DLITRMLD 278 Query: 313 FNPNKRITVEEALAHPYL 330 NP RI V E HP++ Sbjct: 279 KNPESRIVVPEIKLHPWV 296 >5IG1-A nrPDB Length = 344 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 79/292 (27%), Positives = 133/292 (45%), Gaps = 49/292 (16%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENVIGIRDI 106 IG+GA+ V + A+K I+ + + REI I +HE+++ +R Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRRA 84 Query: 107 LRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDH-ICYFLYQILRGLKYIHSANVLH 164 R + Y+V + + +L+ + +++ N+ ++QIL L++ HS N++H Sbjct: 85 FRDES-----HFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIH 139 Query: 165 RDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKG 221 RDLKP NLL+ + +KI DFGLA I + + GF T Y +PE+ + Sbjct: 140 RDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGF----AGTPGYLSPEV-IRRVP 194 Query: 222 YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYL 281 Y ++D+W+ G IL +L P P E+ + + + +N Sbjct: 195 YDTAVDVWACGVILYILLVGYP--------------------PFWEEDHQKLYAQIKNCQ 234 Query: 282 QSLPSKTKVAWAKLFPKSDS---KALDLLDRMLTFNPNKRITVEEALAHPYL 330 PS P+ DS A +L+ ML NP +R TV+E L HP++ Sbjct: 235 YDFPS----------PEWDSVTTAAKELIKAMLEPNPKRRPTVQELLQHPWI 276 >5WAX-A nrPDB Length = 310 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 80/299 (26%), Positives = 127/299 (42%), Gaps = 46/299 (15%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 G RY ++ IG G +G+ + VA+K I E + REI RH Sbjct: 10 GDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKID--ENVQREIINHRSLRHP 67 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLKYI 157 N+I ++++ T A+ +++ +L+ ++ + + S D +F Q++ G+ Y Sbjct: 68 NIIRFKEVILTPTHLAI----VMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 123 Query: 158 HSANVLHRDLKPSNLLIN--TTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 HS V HRDLK N L++ T LKICDFG ++ + H V T Y APE+ Sbjct: 124 HSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSK-SSVLHSQP---KSTVGTPAYIAPEV 179 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG----KHYLDQLNHILGILGSPSQEDLNC 271 +L + K D+WS G L ML F K++ + ILG+ Sbjct: 180 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV----------- 228 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 S+P ++ + DL+ R+ NP RIT+ E HP+ Sbjct: 229 ---------QYSIPDYVHIS---------PECQDLISRIFVANPATRITIPEIRNHPWF 269 >4D28-A nrPDB Length = 446 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 87/320 (27%), Positives = 139/320 (43%), Gaps = 50/320 (15%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILLRFRHE 98 +Y + IGEG + V A + VAIK + S + REI I+ RH Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMET-DLY-KLLKSQQLSNDHICYFLYQILRGLKY 156 N++ + ++L + + +YIV + + +L+ +++ +L D + Q++ + + Sbjct: 70 NIVRLYEVLASKS-----KIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAH 124 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 HS V HRDLKP NLL++T +LK+ DFGL+ + + L + T Y APE+ Sbjct: 125 CHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALP---QEGVELLNDTCGTPNYVAPEV- 180 Query: 217 LNSKGYTKS-IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 L+ +GY S DIWS G IL +L+ F S+ D Sbjct: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPF-------------------SETD------- 214 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 L L K A P ++ L+ R+L NP RI ++ P+ + Y Sbjct: 215 -----LPGLYRKINAAEFDCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYV 269 Query: 336 PTDEPVAEEPFTFAMELDDL 355 P EE + LDD+ Sbjct: 270 PIRAREEEE-----VNLDDI 284 >4JXF-A nrPDB Length = 266 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 81/307 (26%), Positives = 136/307 (44%), Gaps = 53/307 (17%) Query: 32 KGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREI 89 K + F VG +G+G++ V A VAIK I QR E+ Sbjct: 5 KIEDFKVG------NLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEV 58 Query: 90 QILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM---ETDLYKLLKSQQLSNDHICYF 146 +I + +H +++ + + S VY+V ++ E + Y + + S + +F Sbjct: 59 KIHCQLKHPSILELYNYFEDSNY-----VYLVLEMCHNGEMNRYLKNRVKPFSENEARHF 113 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLA-RIADPEHDHTGFLTEYV 205 ++QI+ G+ Y+HS +LHRDL SNLL+ ++KI DFGLA ++ P H Sbjct: 114 MHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTL----C 169 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 T Y +PEI S +S D+WS+GC+ +L RP F + LN ++ Sbjct: 170 GTPNYISPEIATRSAHGLES-DVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV------- 221 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 +Y +PS + +A DL+ ++L NP R+++ L Sbjct: 222 -----------LADY--EMPSFLSI-----------EAKDLIHQLLRRNPADRLSLSSVL 257 Query: 326 AHPYLEQ 332 HP++ + Sbjct: 258 DHPFMSR 264 >1KOB-A nrPDB Length = 387 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 80/314 (25%), Positives = 147/314 (46%), Gaps = 48/314 (15%) Query: 24 VPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTY 81 VP VE+ +G +D Y L+ +G GA+G+V + RV + K +P+ Y Sbjct: 38 VPQPVEVKQGSVYDY---YDILEELGSGAFGVVHRCVEKA-TGRVFVAKFINTPYPLDKY 93 Query: 82 CQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ--QLS 139 + EI I+ + H +I + D + V I++ L +L+ + ++ ++S Sbjct: 94 TVKN--EISIMNQLHHPKLINLHDAFE----DKYEMVLILEFLSGGELFDRIAAEDYKMS 147 Query: 140 NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT--TCDLKICDFGLARIADPEHDH 197 + ++ Q GLK++H +++H D+KP N++ T +KI DFGLA +P+ Sbjct: 148 EAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDE-- 205 Query: 198 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 257 + AT + APEI ++ + D+W++G + +LS F G Sbjct: 206 --IVKVTTATAEFAAPEI-VDREPVGFYTDMWAIGVLGYVLLSGLSPFAG---------- 252 Query: 258 LGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNK 317 ++DL + N+K ++ + A++ + P +A D + +L P K Sbjct: 253 --------EDDLETLQNVKRCDW-----EFDEDAFSSVSP----EAKDFIKNLLQKEPRK 295 Query: 318 RITVEEALAHPYLE 331 R+TV +AL HP+L+ Sbjct: 296 RLTVHDALEHPWLK 309 >3SOA-A nrPDB Length = 444 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 84/301 (27%), Positives = 139/301 (46%), Gaps = 50/301 (16%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVA-----IKKISPFEHQTYCQRTLREIQILLRFR 96 Y + +G+GA+ +V + A KK+S +HQ + RE +I + Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQ----KLEREARICRLLK 68 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICYFLYQILRGL 154 H N++ + D ++ Y++ DL+ +L++ ++ + S + + QIL + Sbjct: 69 HPNIVRLHD-----SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAV 123 Query: 155 KYIHSANVLHRDLKPSNLLINTT---CDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 + H V+HR+LKP NLL+ + +K+ DFGLA + E + + + T Y Sbjct: 124 LHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLA--IEVEGEQQAWFG-FAGTPGYL 180 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 +PE+ L Y K +D+W+ G IL +L P F D+ H L Sbjct: 181 SPEV-LRKDPYGKPVDLWACGVILYILLVGYPPF-----WDEDQHRL------------- 221 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 +KA Y PS W + P+ A DL+++MLT NP+KRIT EAL HP++ Sbjct: 222 YQQIKAGAY--DFPSPE---WDTVTPE----AKDLINKMLTINPSKRITAAEALKHPWIS 272 Query: 332 Q 332 Sbjct: 273 H 273 >1ZXE-A nrPDB Length = 303 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 74/250 (29%), Positives = 118/250 (47%), Gaps = 34/250 (13%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + ++ +G+GA+G V A + + AIKKI E + L E+ +L H+ V+ Sbjct: 8 FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEK--LSTILSEVMLLASLNHQYVV 65 Query: 102 GI-------RDILRASTLEAMRDVYIVQDLME----TDLYKLLKSQQLSN--DHICYFLY 148 R+ ++ T + +Q ME LY L+ S+ L+ D Sbjct: 66 RYYAAWLERRNFVKPMTAVKKKSTLFIQ--MEYCENRTLYDLIHSENLNQQRDEYWRLFR 123 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD-----------H 197 QIL L YIHS ++HR+LKP N+ I+ + ++KI DFGLA+ D Sbjct: 124 QILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGS 183 Query: 198 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 257 + LT + T Y A E++ + Y + ID++S+G I EM I+P ++++N I Sbjct: 184 SDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEM-----IYPFSTGMERVN-I 237 Query: 258 LGILGSPSQE 267 L L S S E Sbjct: 238 LKKLRSVSIE 247 >6CQF-A nrPDB Length = 297 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 83/308 (26%), Positives = 137/308 (44%), Gaps = 51/308 (16%) Query: 36 FDVGPR--YTQLQYIGEGAYGMVSSAYDHVRKTRVAIK--KISPFEHQTYCQRTLREIQI 91 F+ PR Y LQ +G G YG V A D V VA+K K+ P + + Q+ EI I Sbjct: 10 FNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQK---EILI 66 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET----DLYKLLKSQQLSNDHICYFL 147 L RH N++ + ++ ++I + D+Y++ S LS I Y Sbjct: 67 LKTCRHANIVAYH-----GSYLWLQKLWICMEFCGAGSLQDIYQVTGS--LSELQISYVC 119 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGL-ARIADPEHDHTGFLTEYVA 206 ++L+GL Y+HS +HRD+K +N+LIN ++++ DFG+ A+I F + Sbjct: 120 REVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAF----IG 175 Query: 207 TRWYRAPEIMLNS--KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP 264 T ++ APE+ + GY + DIWS+G E+ +P H L Sbjct: 176 TPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLR------------ 223 Query: 265 SQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 ++ + ++ Q K K W+ F + + LT +P KR + + Sbjct: 224 -------VLFLMTKSGYQPPRLKEKGKWSAAFH-------NFIKVTLTKSPKKRPSATKM 269 Query: 325 LAHPYLEQ 332 L+H + Q Sbjct: 270 LSHQLVSQ 277 >3ORZ-A nrPDB Length = 316 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 61/202 (30%), Positives = 93/202 (46%), Gaps = 43/202 (21%) Query: 139 SNDHIC--YFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 S D C ++ +I+ L+Y+H ++HRDLKP N+L+N ++I DFG A++ PE Sbjct: 133 SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESK 192 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF-PGKHYLDQLN 255 +V T Y +PE +L K KS D+W++GCI+ ++++ P F G YL Sbjct: 193 QAR-ANSFVGTAQYVSPE-LLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYL---- 246 Query: 256 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 315 I K P K FP KA DL++++L + Sbjct: 247 -----------------IFQKIIKLEYDFPE-------KFFP----KARDLVEKLLVLDA 278 Query: 316 NKRITVEEA------LAHPYLE 331 KR+ EE AHP+ E Sbjct: 279 TKRLGCEEMEGYGPLKAHPFFE 300 >3FME-A nrPDB Length = 290 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 83/299 (27%), Positives = 134/299 (44%), Gaps = 59/299 (19%) Query: 48 IGEGAYGMVSSAYDHVRKTRV-AIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDI 106 +G GAYG+V HV ++ A+K+I + +R L ++ I +R V + Sbjct: 15 LGRGAYGVVEKMR-HVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR----TVDCPFTV 69 Query: 107 LRASTLEAMRDVYIVQDLMETDLYKLLK-----SQQLSNDHICYFLYQILRGLKYIHSA- 160 L DV+I +LM+T L K K Q + D + I++ L+++HS Sbjct: 70 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 129 Query: 161 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA------TRWYRAPE 214 +V+HRD+KPSN+LIN +K+CDFG+ +G+L + VA + Y APE Sbjct: 130 SVIHRDVKPSNVLINALGQVKMCDFGI----------SGYLVDDVAKDIDAGCKPYMAPE 179 Query: 215 IM---LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 + LN KGY+ DIWS+G + E+ R FP + + ++ PS + Sbjct: 180 RINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSPQ---- 233 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 LP+ K ++ +D + L N +R T E + HP+ Sbjct: 234 ------------LPAD----------KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 270 >3GUB-A nrPDB Length = 295 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 73/251 (29%), Positives = 118/251 (47%), Gaps = 43/251 (17%) Query: 87 REIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLL-KSQQLSNDHIC 144 RE+ IL +H NVI + ++ T DV ++ +L+ +L+ L + + L+ + Sbjct: 63 REVSILKEIQHPNVITLHEVYENKT-----DVILIGELVAGGELFDFLAEKESLTEEEAT 117 Query: 145 YFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC----DLKICDFGLARIADPEHDHTGF 200 FL QIL G+ Y+HS + H DLKP N+++ +KI DFGLA D ++ Sbjct: 118 EFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNI 177 Query: 201 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI 260 T + APEI +N + D+WS+G I +LS F Sbjct: 178 F----GTPEFVAPEI-VNYEPLGLEADMWSIGVITYILLSGASPF--------------- 217 Query: 261 LGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT 320 LG QE L N+ A NY + F + + A D + R+L +P KR+T Sbjct: 218 LGDTKQETL---ANVSAVNYEFE---------DEYFSNTSALAKDFIRRLLVKDPKKRMT 265 Query: 321 VEEALAHPYLE 331 ++++L HP+++ Sbjct: 266 IQDSLQHPWIK 276 >5UNP-A nrPDB Length = 369 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 93/345 (26%), Positives = 148/345 (42%), Gaps = 82/345 (23%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRK-TRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 RY + +GEG +G V DH R RVA+K I E Y + EI +L + Sbjct: 35 RYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVE--KYKEAARLEINVLEK----- 87 Query: 100 VIGIRDILRASTLEAMRDVY-------IVQDLMETDLYKLLKSQQLSNDHICY------- 145 I +D + M D + I +L+ + LK N+++ Y Sbjct: 88 -INEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKD----NNYLPYPIHQVRH 142 Query: 146 FLYQILRGLKYIHSANVLHRDLKPSNLL-INTTCDL------------------KICDFG 186 +Q+ + +K++H + H DLKP N+L +N+ +L ++ DFG Sbjct: 143 MAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFG 202 Query: 187 LARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFP 246 A D EH T V+TR YRAPE++L G+++ D+WS+GCI+ E +F Sbjct: 203 SATF-DHEHHST-----IVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYVGFTLFQ 255 Query: 247 GKHYLDQLNHILGILGS-PSQEDLNCIINMKARNYLQSLPSKTKVAW-----AKLFPKSD 300 + L + ILG PS+ M + Q + ++ W A + + + Sbjct: 256 THDNREHLAMMERILGPIPSR--------MIRKTRKQKYFYRGRLDWDENTSAGRYVREN 307 Query: 301 SKAL---------------DLLDRMLTFNPNKRITVEEALAHPYL 330 K L DL++ ML + P KR+T+ EAL HP+ Sbjct: 308 CKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF 352 >5DBX-A nrPDB Length = 328 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 62/212 (29%), Positives = 101/212 (47%), Gaps = 17/212 (8%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 Y + IG GA +V +A R+ RVAIK+I+ + QT L+EIQ + + H NV+ Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVV 72 Query: 102 GIRDILRASTLEAMRDVYIVQDLME----TDLYKLL------KSQQLSNDHICYFLYQIL 151 ++ ++++V L+ D+ K + K+ L I L ++L Sbjct: 73 TYY-----TSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVL 127 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHT--GFLTEYVATRW 209 GL Y+H +HRDLK N+L+ ++I DFG++ D T ++V T Sbjct: 128 EGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPC 187 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN 241 + APE+M +GY D+WS G E+ + Sbjct: 188 WMAPEVMEQVRGYDFKADMWSFGITAIELATG 219 >5D9K-A nrPDB Length = 330 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 66/238 (27%), Positives = 119/238 (50%), Gaps = 30/238 (12%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHEN 99 ++ L+ +G+G++G V +KKIS + Q Y + L++ + +R R Sbjct: 31 QFELLKVLGQGSFGKV-----------FLVKKISGSDARQLYAMKVLKKATLKVRDRVRT 79 Query: 100 VIGIRDILRAST----------LEAMRDVYIVQDLMET-DLY-KLLKSQQLSNDHICYFL 147 + RDIL + +Y++ D + DL+ +L K + + + ++L Sbjct: 80 KME-RDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYL 138 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 ++ L ++HS +++RDLKP N+L++ +K+ DFGL++ + DH + T Sbjct: 139 AELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESI---DHEKKAYSFCGT 195 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL-GILGSP 264 Y APE+ +N +G+T+S D WS G ++ EML+ F GK + + IL LG P Sbjct: 196 VEYMAPEV-VNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP 252 >4C0T-A nrPDB Length = 974 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 81/303 (26%), Positives = 136/303 (44%), Gaps = 51/303 (16%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF--RHENVIGIRD 105 +GEG+Y V A D + + A+K + + ++ ++ + I R N +G+ Sbjct: 274 LGEGSYSTVILATDKITGKQYAVKVLD--KRHIIKEKKVKYVNIEKHALNRLSNRLGV-- 329 Query: 106 ILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDHIC-YFLYQILRGLKYIHSANVL 163 I T + +Y V D +L L+K N+ +F QIL +KY+H V+ Sbjct: 330 ISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDNGVI 389 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTG------FLTEYVATRWYRAPEIML 217 HRDLKP N+L++ ++I DFG AR+ + ++D + +V T Y +PE++ Sbjct: 390 HRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELLE 449 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 N K K D+W+ GCI+ +M++ +P F KA Sbjct: 450 N-KYCGKPGDVWAFGCIIYQMIAGKPPF------------------------------KA 478 Query: 278 RNYLQSLPSKTKV--AWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 N + TK+ A++ FP + DL+ ++L P++R T+ E H Y Q D Sbjct: 479 TNEYLTFQKITKLQFAFSAGFP---TIIRDLIKKILVLQPSRRATIPEIQKH-YFFQSVD 534 Query: 336 PTD 338 D Sbjct: 535 FKD 537 >2JC6-A nrPDB Length = 334 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 78/307 (25%), Positives = 133/307 (43%), Gaps = 48/307 (15%) Query: 32 KGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQI 91 K Q D+ + + +G GA+ V A + A+K I + EI + Sbjct: 14 KKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAV 73 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLY-KLLKSQQLSNDHICYFLYQ 149 L + +HEN++ + DI E+ +Y+V L+ +L+ ++++ + + Q Sbjct: 74 LRKIKHENIVALEDIY-----ESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQ 128 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLI---NTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 +L + Y+H ++HRDLKP NLL + + I DFGL+++ ++ Sbjct: 129 VLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM----EGKGDVMSTACG 184 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI---LGS 263 T Y APE+ L K Y+K++D WS+G I +L P F ++ IL S Sbjct: 185 TPGYVAPEV-LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDS 243 Query: 264 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEE 323 P +D+ SDS A D + ++ +PNKR T E+ Sbjct: 244 PYWDDI-----------------------------SDS-AKDFIRNLMEKDPNKRYTCEQ 273 Query: 324 ALAHPYL 330 A HP++ Sbjct: 274 AARHPWI 280 >4UZD-A nrPDB Length = 287 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 72/288 (25%), Positives = 128/288 (44%), Gaps = 48/288 (16%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 +G+G +G V A + K +A+K + + E + RE++I RH N++ + Sbjct: 16 LGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYG 75 Query: 106 ILRASTLEAMRDVYIVQDL--METDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 +T VY++ + + T +L K + ++ ++ L Y HS V+ Sbjct: 76 YFHDAT-----RVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVI 130 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 223 HRD+KP NLL+ + +LKI DFG + H + T T Y PE M+ + + Sbjct: 131 HRDIKPENLLLGSAGELKIADFGWS-----VHAPSSRRTTLCGTLDYLPPE-MIEGRMHD 184 Query: 224 KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQS 283 + +D+WS+G + E L +P F +A Y ++ Sbjct: 185 EKVDLWSLGVLCYEFLVGKPPF------------------------------EANTYQET 214 Query: 284 LPSKTKVAWAKLFPKSDSK-ALDLLDRMLTFNPNKRITVEEALAHPYL 330 ++V + FP ++ A DL+ R+L NP++R + E L HP++ Sbjct: 215 YKRISRVEFT--FPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI 260 >3D2K-A nrPDB Length = 272 Score = 88.2 bits (217), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 75/303 (24%), Positives = 135/303 (44%), Gaps = 54/303 (17%) Query: 34 QPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQI 91 + FD+G + +G+G +G V A + K +A+K + + E + RE++I Sbjct: 12 EDFDIG------RPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEI 65 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDL--METDLYKLLKSQQLSNDHICYFLYQ 149 RH N++ + +T VY++ + + T +L K + ++ + Sbjct: 66 QSHLRHPNILRLYGYFHDAT-----RVYLILEYAPLGTVYRELQKLSRFDEQRTATYITE 120 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW 209 + L Y HS V+HRD+KP NLL+ + +LKI DFG + H + T T Sbjct: 121 LANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWS-----VHAPSSRRTTLCGTLD 175 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 269 Y PE M+ + + + +D+WS+G + E L P F Sbjct: 176 YLPPE-MIEGRMHDEKVDLWSLGVLCYEFLVGMPPF------------------------ 210 Query: 270 NCIINMKARNYLQSLPSKTKVAWAKLFPKSDSK-ALDLLDRMLTFNPNKRITVEEALAHP 328 +A Y ++ ++V + FP ++ A DL+ R+L N ++R+T+ E L HP Sbjct: 211 ------EAHTYQETYRRISRVEFT--FPDFVTEGARDLISRLLKHNASQRLTLAEVLEHP 262 Query: 329 YLE 331 +++ Sbjct: 263 WIK 265 >2J90-A nrPDB Length = 304 Score = 88.2 bits (217), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 71/251 (28%), Positives = 115/251 (45%), Gaps = 43/251 (17%) Query: 87 REIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLL-KSQQLSNDHIC 144 RE+ IL RH N+I + DI T DV ++ +L+ +L+ L + + L+ D Sbjct: 78 REVNILREIRHPNIITLHDIFENKT-----DVVLILELVSGGELFDFLAEKESLTEDEAT 132 Query: 145 YFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC----DLKICDFGLARIADPEHDHTGF 200 FL QIL G+ Y+HS + H DLKP N+++ +K+ DFG+A + ++ Sbjct: 133 QFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNI 192 Query: 201 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI 260 T + APEI +N + D+WS+G I +LS F Sbjct: 193 F----GTPEFVAPEI-VNYEPLGLEADMWSIGVITYILLSGASPF--------------- 232 Query: 261 LGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT 320 LG QE L N+ A NY + F + A D + R+L +P +R+T Sbjct: 233 LGETKQETLT---NISAVNYDFD---------EEYFSNTSELAKDFIRRLLVKDPKRRMT 280 Query: 321 VEEALAHPYLE 331 + ++L H +++ Sbjct: 281 IAQSLEHSWIK 291 >2OU7-A nrPDB Length = 335 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 78/306 (25%), Positives = 132/306 (43%), Gaps = 56/306 (18%) Query: 47 YIGEGAYGMVSSAYD----HVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 ++G+G + D V ++ K + HQ ++ EI I H++V+G Sbjct: 48 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQR--EKMSMEISIHRSLAHQHVVG 105 Query: 103 IRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSA 160 + V++V +L L +L K ++ L+ Y+L QI+ G +Y+H Sbjct: 106 FHGFFEDNDF-----VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRN 160 Query: 161 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 V+HRDLK NL +N ++KI DFGLA + + + L T Y APE+ L+ K Sbjct: 161 RVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVL---CGTPNYIAPEV-LSKK 216 Query: 221 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI----INMK 276 G++ +D+WS+GCI+ +L +P F + +C+ + +K Sbjct: 217 GHSFEVDVWSIGCIMYTLLVGKPPF----------------------ETSCLKETYLRIK 254 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 Y S+P + A L+ +ML +P R T+ E L + Y P Sbjct: 255 KNEY--SIPKHI-----------NPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIP 301 Query: 337 TDEPVA 342 P+ Sbjct: 302 ARLPIT 307 >5ES1-A nrPDB Length = 328 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 81/313 (25%), Positives = 138/313 (44%), Gaps = 50/313 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENV 100 Y L+ IG+G + V A + VAIK I + + + Q+ RE++I+ H N+ Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 76 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ-QLSNDHICYFLYQILRGLKYIH 158 + + +++ E + +Y+V + +++ L S ++ QI+ + Y H Sbjct: 77 VKLFEVI-----ETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCH 131 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 N++HRDLK NLL++ ++KI DFG + E L + + Y APE+ Sbjct: 132 QKNIVHRDLKAENLLLDAEANIKIADFGFSN----EFTLGSKLDTFCGSPPYAAPELFQG 187 Query: 219 SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKAR 278 K +DIWS+G IL ++S F G H L +L Sbjct: 188 KKYDGPEVDIWSLGVILYTLVSGSLPFDG-HNLKELRE---------------------- 224 Query: 279 NYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD--- 335 + L K +V + + +D ++ +L R L NP KR T+E+ + ++ Y+ Sbjct: 225 ---RVLRGKYRVPF---YMSTDCES--ILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEE 276 Query: 336 --PTDEPVAEEPF 346 P EP EE F Sbjct: 277 LKPYTEP--EEDF 287 >2Z7Q-A nrPDB Length = 321 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 76/314 (24%), Positives = 139/314 (44%), Gaps = 46/314 (14%) Query: 13 EPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKK 72 +P + EGV + + G + L+ +G+G++G V ++K Sbjct: 1 QPSKDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKV-----------FLVRK 49 Query: 73 IS-PFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAST----------LEAMRDVYIV 121 ++ P Y + L++ + +R R + RDIL + +Y++ Sbjct: 50 VTRPDSGHLYAMKVLKKATLKVRDRVRTKME-RDILADVNHPFVVKLHYAFQTEGKLYLI 108 Query: 122 QDLMET-DLY-KLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD 179 D + DL+ +L K + + + ++L ++ GL ++HS +++RDLKP N+L++ Sbjct: 109 LDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGH 168 Query: 180 LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239 +K+ DFGL++ A DH + T Y APE+ +N +G++ S D WS G ++ EML Sbjct: 169 IKLTDFGLSKEAI---DHEKKAYSFCGTVEYMAPEV-VNRQGHSHSADWWSYGVLMFEML 224 Query: 240 SNRPIFPGKHYLDQLNHILG-------ILGSPSQEDLNCIINMKARNYLQSLPSK----- 287 + F GK + + IL L + +Q L + N L S P Sbjct: 225 TGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIK 284 Query: 288 -----TKVAWAKLF 296 + + W KL+ Sbjct: 285 RHVFYSTIDWNKLY 298 >4J52-A nrPDB Length = 293 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 78/306 (25%), Positives = 132/306 (43%), Gaps = 56/306 (18%) Query: 47 YIGEGAYGMVSSAYD----HVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 ++G+G + D V ++ K + HQ ++ EI I H++V+G Sbjct: 21 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQR--EKMSMEISIHRSLAHQHVVG 78 Query: 103 IRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSA 160 + V++V +L L +L K ++ L+ Y+L QI+ G +Y+H Sbjct: 79 FHGFFEDNDF-----VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRN 133 Query: 161 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 V+HRDLK NL +N ++KI DFGLA + + + L T Y APE+ L+ K Sbjct: 134 RVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLC---GTPNYIAPEV-LSKK 189 Query: 221 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI----INMK 276 G++ +D+WS+GCI+ +L +P F + +C+ + +K Sbjct: 190 GHSFEVDVWSIGCIMYTLLVGKPPF----------------------ETSCLKETYLRIK 227 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 Y S+P + A L+ +ML +P R T+ E L + Y P Sbjct: 228 KNEY--SIPKHI-----------NPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIP 274 Query: 337 TDEPVA 342 P+ Sbjct: 275 ARLPIT 280 >4L42-A nrPDB Length = 346 Score = 87.8 bits (216), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 85/327 (25%), Positives = 146/327 (44%), Gaps = 65/327 (19%) Query: 23 GVPGEVEMVKGQPFDVGPR-YTQLQYIGEGAYGMVSSAYDHVRKTRVA----------IK 71 G E + +G P + P + L+ +G+G YG V VRK A +K Sbjct: 1 GAMSETSVNRG-PEKIRPECFELLRVLGKGGYGKVF----QVRKVTGANTGKIFAMKVLK 55 Query: 72 KISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQD-LMETDLY 130 K + T E IL +H ++ D++ A + +Y++ + L +L+ Sbjct: 56 KAMIVRNAKDTAHTKAERNILEEVKHPFIV---DLIYA--FQTGGKLYLILEYLSGGELF 110 Query: 131 KLLKSQQL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR 189 L+ + + D C++L +I L ++H +++RDLKP N+++N +K+ DFGL + Sbjct: 111 MQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCK 170 Query: 190 IADPEHDHTGFLTE-YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 248 E H G +T + T Y APEI++ S G+ +++D WS+G ++ +ML+ P F G+ Sbjct: 171 ----ESIHDGTVTHTFCGTIEYMAPEILMRS-GHNRAVDWWSLGALMYDMLTGAPPFTGE 225 Query: 249 HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLD 308 + ++ I L C +N LP P +A DLL Sbjct: 226 NRKKTIDKI-----------LKCKLN---------LP-----------PYLTQEARDLLK 254 Query: 309 RMLTFNPNKRI-----TVEEALAHPYL 330 ++L N R+ E AHP+ Sbjct: 255 KLLKRNAASRLGAGPGDAGEVQAHPFF 281 >3UTO-A nrPDB Length = 573 Score = 87.8 bits (216), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 70/288 (24%), Positives = 126/288 (43%), Gaps = 43/288 (14%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFRHENVIGIRDI 106 +G GA+G+V + A K + +P H++ + +EIQ + RH ++ + D Sbjct: 165 LGTGAFGVVHRVTERATGNNFAAKFVMTP--HESDKETVRKEIQTMSVLRHPTLVNLHDA 222 Query: 107 LRASTLEAMRDVYIVQDLMETDLYKLLKSQ--QLSNDHICYFLYQILRGLKYIHSANVLH 164 M I + + +L++ + + ++S D ++ Q+ +GL ++H N +H Sbjct: 223 FEDDNEMVM----IYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVH 278 Query: 165 RDLKPSNLLINT--TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 DLKP N++ T + +LK+ DFGL DP+ + T + APE+ K Sbjct: 279 LDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQS----VKVTTGTAEFAAPEVA-EGKPV 333 Query: 223 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ 282 D+WSVG + +LS F G++ + L ++ +C NM Sbjct: 334 GYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNV-----------KSCDWNMD------ 376 Query: 283 SLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 F D + ++L +PN R+T+ +AL HP+L Sbjct: 377 ----------DSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 414 >3HDN-A nrPDB Length = 373 Score = 87.4 bits (215), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 83/318 (26%), Positives = 151/318 (47%), Gaps = 45/318 (14%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILLR-FRHENVI 101 L+ IG+G++G V A + A+K + + + + E +LL+ +H ++ Sbjct: 43 LKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLV 102 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159 G+ + + +Y V D + Y L + + ++ +I L Y+HS Sbjct: 103 GLH-----FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS 157 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 N+++RDLKP N+L+++ + + DFGL + + EH+ T + + T Y APE+ L+ Sbjct: 158 LNIVYRDLKPENILLDSQGHIVLTDFGLCK-ENIEHNSTT--STFCGTPEYLAPEV-LHK 213 Query: 220 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN 279 + Y +++D W +G +L EML P F ++ + ++ IL P Q N I AR+ Sbjct: 214 QPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDN---ILNKPLQLKPN--ITNSARH 268 Query: 280 YLQSLPSKTKVAWAKLFPKSDSKAL------------DLLDRMLT--FNPNKRITVEEAL 325 L+ L K + +L K D + DL+++ +T FNPN + Sbjct: 269 LLEGLLQKDRT--KRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN--------V 318 Query: 326 AHPYLEQYYDP--TDEPV 341 + P +++DP T+EPV Sbjct: 319 SGPNDLRHFDPEFTEEPV 336 >3KN6-A nrPDB Length = 325 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 76/299 (25%), Positives = 131/299 (43%), Gaps = 37/299 (12%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQIL-LRFRHENVIGIRDI 106 +GEG++ + A+K IS + T +EI L L H N++ + ++ Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIIS----KRMEANTQKEITALKLCEGHPNIVKLHEV 74 Query: 107 LRASTLEAMRDVYIVQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHR 165 + + +++ L +L+ ++ K + S Y + +++ + ++H V+HR Sbjct: 75 FH----DQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 130 Query: 166 DLKPSNLLI---NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 DLKP NLL N ++KI DFG AR+ P++ L T Y APE +LN GY Sbjct: 131 DLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQP---LKTPCFTLHYAAPE-LLNQNGY 186 Query: 223 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ 282 +S D+WS+G IL MLS + F + I+ + D Sbjct: 187 DESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDF------------- 233 Query: 283 SLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPV 341 S AW + +A DL+ +LT +PNKR+ + + +L+ + P+ Sbjct: 234 ---SFEGEAWKNV----SQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPL 285 >4QMW-A nrPDB Length = 310 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 67/225 (29%), Positives = 113/225 (50%), Gaps = 14/225 (6%) Query: 20 VGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQ 79 V G+PG ++ +K P ++ +T+L+ IG+G++G V D+ + VAIK I E + Sbjct: 13 VQSGLPG-MQNLKADPEEL---FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAE 68 Query: 80 TYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLS 139 + +EI +L + V S L+ + I++ L LL+ L Sbjct: 69 DEIEDIQQEITVLSQCDSPYVTK----YYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLD 124 Query: 140 NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLA-RIADPEHDHT 198 I L +IL+GL Y+HS +HRD+K +N+L++ ++K+ DFG+A ++ D + Sbjct: 125 ETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRN 184 Query: 199 GFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRP 243 F V T ++ APE++ S Y DIWS+G E+ P Sbjct: 185 TF----VGTPFWMAPEVIKQS-AYDSKADIWSLGITAIELARGEP 224 >3DB8-A nrPDB Length = 317 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 82/312 (26%), Positives = 135/312 (43%), Gaps = 56/312 (17%) Query: 41 RYTQLQYIGEGAYGMVSSAYD----HVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 RY + +++G+G + D V +V K + HQ ++ EI I Sbjct: 43 RYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQK--EKMSTEIAIHKSLD 100 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRGL 154 + +V+G VY+V ++ L +L K ++ ++ YF+ Q ++G+ Sbjct: 101 NPHVVGFHGFFEDDDF-----VYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGV 155 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 +Y+H+ V+HRDLK NL +N D+KI DFGLA + + + + T Y APE Sbjct: 156 QYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERK---KDLCGTPNYIAPE 212 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI-- 272 + L KG++ +DIWS+GCIL +L +P F + +C+ Sbjct: 213 V-LCKKGHSFEVDIWSLGCILYTLLVGKPPF----------------------ETSCLKE 249 Query: 273 --INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 I +K Y S+P + A L+ RML +P R +V E L + Sbjct: 250 TYIRIKKNEY--SVPRHI-----------NPVASALIRRMLHADPTLRPSVAELLTDEFF 296 Query: 331 EQYYDPTDEPVA 342 Y P P + Sbjct: 297 TSGYAPMRLPTS 308 >6GQK-A nrPDB Length = 328 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 104/219 (47%), Gaps = 35/219 (15%) Query: 48 IGEGAYGMV--SSAYDHVRK---TRVAIKKISPFEHQTYCQRTLREIQILLRF-RHENVI 101 +G GA+G V ++A ++ VA+K + P H T + + E+++L HEN++ Sbjct: 49 LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHENIV 108 Query: 102 GIRDILRAST--------------------LEAMRDVYIVQDLMETDLYKLLKSQQLSND 141 ++L A T L RD ++ + DLYK L+ + Sbjct: 109 ---NLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDF----LTLE 161 Query: 142 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFL 201 H+ F YQ+ +G+ ++ S N +HRDL N+L+ KICDFGLAR + ++ Sbjct: 162 HLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDKG 221 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + +W APE + NS YT D+WS G L E+ S Sbjct: 222 NARLPVKW-MAPESIFNSV-YTFESDVWSYGIFLWELFS 258 >1KOA-A nrPDB Length = 491 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 70/288 (24%), Positives = 126/288 (43%), Gaps = 43/288 (14%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFRHENVIGIRDI 106 +G GA+G+V + A K + +P H++ + +EIQ + RH ++ + D Sbjct: 59 LGTGAFGVVHRVTERATGNNFAAKFVMTP--HESDKETVRKEIQTMSVLRHPTLVNLHDA 116 Query: 107 LRASTLEAMRDVYIVQDLMETDLYKLLKSQ--QLSNDHICYFLYQILRGLKYIHSANVLH 164 M I + + +L++ + + ++S D ++ Q+ +GL ++H N +H Sbjct: 117 FEDDNEMVM----IYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVH 172 Query: 165 RDLKPSNLLINT--TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 DLKP N++ T + +LK+ DFGL DP+ + T + APE+ K Sbjct: 173 LDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQS----VKVTTGTAEFAAPEVA-EGKPV 227 Query: 223 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ 282 D+WSVG + +LS F G++ + L ++ +C NM Sbjct: 228 GYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNV-----------KSCDWNMD------ 270 Query: 283 SLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 F D + ++L +PN R+T+ +AL HP+L Sbjct: 271 ----------DSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 308 >4JDH-A nrPDB Length = 346 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 71/291 (24%), Positives = 128/291 (43%), Gaps = 39/291 (13%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 IGEG+ G+V A VA+KK+ Q + E+ I+ ++HENV+ + + Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMD-LRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 140 Query: 108 RASTLEAMRDVYIVQDLMETD-LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRD 166 ++++V + +E L ++ +++ + I +L+ L +H+ V+HRD Sbjct: 141 LVGD-----ELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 195 Query: 167 LKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSI 226 +K ++L+ +K+ DFG E L V T ++ APE +++ Y + Sbjct: 196 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSL---VGTPYWMAPE-LISRLPYGPEV 251 Query: 227 DIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPS 286 DIWS+G ++ EM+ P + P + + I + +LP Sbjct: 252 DIWSLGIMVIEMVDGEPPY---------------FNEPPLKAMKMIRD--------NLPP 288 Query: 287 KTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 + K K+ P LDR+L +P +R T E L HP+L + P Sbjct: 289 RLK-NLHKVSPSLKG----FLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 334 >4X3F-A nrPDB Length = 337 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 69/223 (30%), Positives = 104/223 (46%), Gaps = 10/223 (4%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQ-TYCQRTLREIQILLRFRHE 98 RY + I G G V A D+ RVA+K + S F + +R E + H Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 72 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLK-SQQLSNDHICYFLYQILRGLKY 156 + + D + R Y+V +L+ + L +LK + +LS H L Q R L+ Sbjct: 73 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 132 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH-DHTGFLTEYVATRWYRAPEI 215 H+A ++HRD+KP N+LI T +KI DFG+A+ D TG + + T Y APE Sbjct: 133 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMV---MGTAQYIAPEQ 189 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLD-QLNHI 257 L S D++S+G + E +S + F G L + HI Sbjct: 190 ALGHDASPAS-DVYSLGVVGYEAVSGKRPFAGDGALTVAMKHI 231 >3COM-A nrPDB Length = 314 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 84/309 (27%), Positives = 137/309 (44%), Gaps = 64/309 (20%) Query: 34 QPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILL 93 QP +V + L+ +GEG+YG V A VAIK++ P E Q ++EI I+ Sbjct: 26 QPEEV---FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV-PVESD--LQEIIKEISIMQ 79 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLME----TDLYKLLKSQQLSNDHICYFLYQ 149 + +V+ +T D++IV + +D+ +L +++ L+ D I L Sbjct: 80 QCDSPHVVKYYGSYFKNT-----DLWIVMEYCGAGSVSDIIRL-RNKTLTEDEIATILQS 133 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR- 208 L+GL+Y+H +HRD+K N+L+NT K+ DFG+A G LT+ +A R Sbjct: 134 TLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVA----------GQLTDTMAKRN 183 Query: 209 ------WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILG 262 ++ APE+ + GY DIWS+G EM +P + H + I I Sbjct: 184 TVIGTPFWMAPEV-IQEIGYNCVADIWSLGITAIEMAEGKPPYADIH---PMRAIFMIPT 239 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTKVA-WAKLFPKSDSKALDLLDRMLTFNPNKRITV 321 +P P+ K W+ F D + + L +P +R T Sbjct: 240 NPP-------------------PTFRKPELWSDNF-------TDFVKQCLVKSPEQRATA 273 Query: 322 EEALAHPYL 330 + L HP++ Sbjct: 274 TQLLQHPFV 282 >4OW8-A nrPDB Length = 283 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 69/223 (30%), Positives = 104/223 (46%), Gaps = 10/223 (4%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQ-TYCQRTLREIQILLRFRHE 98 RY + I G G V A D+ RVA+K + S F + +R E + H Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLK-SQQLSNDHICYFLYQILRGLKY 156 + + D + R Y+V +L+ + L +LK + +LS H L Q R L+ Sbjct: 72 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 131 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH-DHTGFLTEYVATRWYRAPEI 215 H+A ++HRD+KP N+LI T +KI DFG+A+ D TG + + T Y APE Sbjct: 132 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMV---MGTAQYIAPEQ 188 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLD-QLNHI 257 L S D++S+G + E +S + F G L + HI Sbjct: 189 ALGHDASPAS-DVYSLGVVGYEAVSGKRPFAGDGALTVAMKHI 230 >4RLP-A nrPDB Length = 288 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 80/309 (25%), Positives = 138/309 (44%), Gaps = 63/309 (20%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVA----------IKKISPFEHQTYCQRTLREIQI 91 + L+ +G+G YG V VRK A +KK + T E I Sbjct: 7 FELLRVLGKGGYGKVFQ----VRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI 62 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQD-LMETDLYKLLKSQQL-SNDHICYFLYQ 149 L +H ++ D++ A + +Y++ + L +L+ L+ + + D C++L + Sbjct: 63 LEEVKHPFIV---DLIYA--FQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAE 117 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVATR 208 I L ++H +++RDLKP N+++N +K+ DFGL + E H G +T + T Sbjct: 118 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCK----ESIHDGTVTHTFCGTI 173 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 Y APEI++ S G+ +++D WS+G ++ +ML+ P F G++ ++ I Sbjct: 174 EYMAPEILMRS-GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKI----------- 221 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT-----VEE 323 L C +N LP P +A DLL ++L N R+ E Sbjct: 222 LKCKLN---------LP-----------PYLTQEARDLLKKLLKRNAASRLGAGPGDAGE 261 Query: 324 ALAHPYLEQ 332 AHP+ Sbjct: 262 VQAHPFFRH 270 >6B2Q-A nrPDB Length = 317 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 69/223 (30%), Positives = 104/223 (46%), Gaps = 10/223 (4%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQ-TYCQRTLREIQILLRFRHE 98 RY + I G G V A D+ RVA+K + S F + +R E + H Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLK-SQQLSNDHICYFLYQILRGLKY 156 + + D + R Y+V +L+ + L +LK + +LS H L Q R L+ Sbjct: 93 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 152 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH-DHTGFLTEYVATRWYRAPEI 215 H+A ++HRD+KP N+LI T +KI DFG+A+ D TG + + T Y APE Sbjct: 153 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMV---MGTAQYIAPEQ 209 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLD-QLNHI 257 L S D++S+G + E +S + F G L + HI Sbjct: 210 ALGHDASPAS-DVYSLGVVGYEAVSGKRPFAGDGALTVAMKHI 251 >3PPZ-A nrPDB Length = 309 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 61/203 (30%), Positives = 98/203 (48%), Gaps = 19/203 (9%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 + IG G++G V A H V I F H LRE+ I+ R RH N++ Sbjct: 43 EKIGAGSFGTVHRAEWHGSDVAVKILMEQDF-HAERVNEFLREVAIMKRLRHPNIV---- 97 Query: 106 ILRASTLEAMRDVYIVQDLMETDLYKLLKS----QQLSNDHICYFLYQILRGLKYIHSAN 161 + + + + + L LY+LL +QL Y + +G+ Y+H+ N Sbjct: 98 LFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRN 157 Query: 162 --VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA--TRWYRAPEIML 217 ++HRDLK NLL++ +K+CDFGL+R+ + FL+ A T + APE++ Sbjct: 158 PPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLK-----ASTFLSSKSAAGTPEWMAPEVLR 212 Query: 218 NSKGYTKSIDIWSVGCILAEMLS 240 + KS D++S G IL E+ + Sbjct: 213 DEPSNEKS-DVYSFGVILWELAT 234 >2XIK-A nrPDB Length = 294 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 63/203 (31%), Positives = 102/203 (50%), Gaps = 10/203 (4%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 +T+L IG+G++G V D+ K VAIK I E + + +EI +L + + Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 80 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSAN 161 S L++ + I++ L LLK L +I L +IL+GL Y+HS Sbjct: 81 R----YFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSER 136 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLA-RIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 +HRD+K +N+L++ D+K+ DFG+A ++ D + F V T ++ APE++ S Sbjct: 137 KIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTF----VGTPFWMAPEVIKQS- 191 Query: 221 GYTKSIDIWSVGCILAEMLSNRP 243 Y DIWS+G E+ P Sbjct: 192 AYDFKADIWSLGITAIELAKGEP 214 >4WNO-A nrPDB Length = 287 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 73/251 (29%), Positives = 115/251 (45%), Gaps = 39/251 (15%) Query: 8 GGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMV-SSAYDHVRKT 66 GGG EP R G G+ E +++ IG GA+ +V + Sbjct: 1 GGGSMEPGRG---GTETVGKFE------------FSRKDLIGHGAFAVVFKGRHRAAHDL 45 Query: 67 RVAIKKISPFEHQTYCQRTL-REIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM 125 VA+K I+ ++ Q L +EI+IL +HEN++ + D E VY+V + Sbjct: 46 EVAVKCINK-KNLAKSQTLLGKEIKILKELKHENIVALYDFQ-----EMANSVYLVMEYC 99 Query: 126 ET-DLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN-------- 175 DL L + + LS D I FL QI ++ +HS ++HRDLKP N+L++ Sbjct: 100 NGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRAN 159 Query: 176 -TTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCI 234 + +KI DFG AR + Y APE+++ S+ Y D+WS+G I Sbjct: 160 PNSIRVKIADFGFARYLQSNM----MAATLCGSPMYMAPEVIM-SQHYDGKADLWSIGTI 214 Query: 235 LAEMLSNRPIF 245 + + L+ + F Sbjct: 215 VYQCLTGKAPF 225 >4FIE-A nrPDB Length = 423 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 71/291 (24%), Positives = 128/291 (43%), Gaps = 39/291 (13%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 IGEG+ G+V A VA+KK+ Q + E+ I+ ++HENV+ + + Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMD-LRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 217 Query: 108 RASTLEAMRDVYIVQDLMETD-LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRD 166 ++++V + +E L ++ +++ + I +L+ L +H+ V+HRD Sbjct: 218 LVGD-----ELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 272 Query: 167 LKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSI 226 +K ++L+ +K+ DFG E L V T ++ APE +++ Y + Sbjct: 273 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSL---VGTPYWMAPE-LISRLPYGPEV 328 Query: 227 DIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPS 286 DIWS+G ++ EM+ P + P + + I + +LP Sbjct: 329 DIWSLGIMVIEMVDGEPPY---------------FNEPPLKAMKMIRD--------NLPP 365 Query: 287 KTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 + K K+ P LDR+L +P +R T E L HP+L + P Sbjct: 366 RLK-NLHKVSPSLKG----FLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 411 >5YKS-A nrPDB Length = 377 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 80/322 (24%), Positives = 142/322 (44%), Gaps = 49/322 (15%) Query: 21 GPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQT 80 GP + G +G + Y + +G G + +V A +VA+K I + T Sbjct: 19 GPHMAG---FKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT 75 Query: 81 YCQRTL-REIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ- 137 L +E++ + +H N++ + +++ T +Y++ +L + D++ + + Sbjct: 76 LATGHLFQEVRCMKLVQHPNIVRLYEVIDTQT-----KLYLILELGDGGDMFDYIMKHEE 130 Query: 138 -LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL-KICDFGLARIADPEH 195 L+ D + QI+ + Y H +V+HRDLKP N++ L K+ DFG + P Sbjct: 131 GLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGK 190 Query: 196 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLN 255 LT + Y APEI+L + ++DIWS+G IL ++ +P F Sbjct: 191 K----LTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQ--------- 237 Query: 256 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 315 + E L I++ K ++PS + DL+ RML +P Sbjct: 238 ------EANDSETLTMIMDCK-----YTVPSHVS-----------KECKDLITRMLQRDP 275 Query: 316 NKRITVEEALAHPYLEQYYDPT 337 +R ++EE HP+L Q DP+ Sbjct: 276 KRRASLEEIENHPWL-QGVDPS 296 >1JPA-A nrPDB Length = 312 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 66/222 (29%), Positives = 105/222 (47%), Gaps = 24/222 (10%) Query: 46 QYIGEGAYGMVSSAYDHV---RKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 Q IG G +G V S + + R+ VAIK + + + L E I+ +F H NVI Sbjct: 39 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIH 98 Query: 103 IRDILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159 + ++ ST V I+ + ME D + Q + + L I G+KY+ Sbjct: 99 LEGVVTKST-----PVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAD 153 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARI-----ADPEHDHTGFLTEYVATRWYRAPE 214 N +HRDL N+L+N+ K+ DFGL+R +DP +T L + RW APE Sbjct: 154 MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPT--YTSALGGKIPIRW-TAPE 210 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 + + +T + D+WS G ++ E++S + + Y D N Sbjct: 211 -AIQYRKFTSASDVWSYGIVMWEVMS----YGERPYWDMTNQ 247 >2W4O-A nrPDB Length = 349 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 81/289 (28%), Positives = 131/289 (45%), Gaps = 46/289 (15%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-EIQILLRFRHENVIGIRDI 106 +G GA +V + A+K + +T ++ +R EI +LLR H N+I +++I Sbjct: 61 LGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRTEIGVLLRLSHPNIIKLKEI 116 Query: 107 LRAST-LEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHR 165 T + + ++ +L + + K S++ + D + QIL + Y+H ++HR Sbjct: 117 FETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAV----KQILEAVAYLHENGIVHR 172 Query: 166 DLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 DLKP NLL T LKI DFGL++I +H + T Y APEI L Y Sbjct: 173 DLKPENLLYATPAPDAPLKIADFGLSKIV----EHQVLMKTVCGTPGYCAPEI-LRGCAY 227 Query: 223 TKSIDIWSVGCILAEMLSN-RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYL 281 +D+WSVG I +L P + + DQ + LNC Y Sbjct: 228 GPEVDMWSVGIITYILLCGFEPFYDERG--DQFMF---------RRILNC-------EYY 269 Query: 282 QSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 P +V+ A DL+ +++ +P KR+T +AL HP++ Sbjct: 270 FISPWWDEVSL---------NAKDLVRKLIVLDPKKRLTTFQALQHPWV 309 >2Q0N-A nrPDB Length = 301 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 71/291 (24%), Positives = 128/291 (43%), Gaps = 39/291 (13%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 IGEG+ G+V A VA+KK+ Q + E+ I+ ++HENV+ + + Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKMD-LRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 95 Query: 108 RASTLEAMRDVYIVQDLMETD-LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRD 166 ++++V + +E L ++ +++ + I +L+ L +H+ V+HRD Sbjct: 96 LVGD-----ELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 150 Query: 167 LKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSI 226 +K ++L+ +K+ DFG E L V T ++ APE +++ Y + Sbjct: 151 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSL---VGTPYWMAPE-LISRLPYGPEV 206 Query: 227 DIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPS 286 DIWS+G ++ EM+ P + P + + I + +LP Sbjct: 207 DIWSLGIMVIEMVDGEPPY---------------FNEPPLKAMKMIRD--------NLPP 243 Query: 287 KTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 + K K+ P LDR+L +P +R T E L HP+L + P Sbjct: 244 RLK-NLHKVSPSLKG----FLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 289 >4KIK-B nrPDB Length = 677 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 67/216 (31%), Positives = 100/216 (46%), Gaps = 27/216 (12%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKK----ISPFEHQTYCQRTLREIQILLRFRHENVIGI 103 +G G +G V ++ ++AIK+ +SP + +C EIQI+ R H NV+ Sbjct: 27 LGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWC----LEIQIMRRLTHPNVVAA 82 Query: 104 RDILRASTLEAMRDVYIVQDLME----TDLYKLLKSQQ----LSNDHICYFLYQILRGLK 155 RD+ A D+ ++ ME DL K L + L I L I L+ Sbjct: 83 RDVPEGMQNLAPNDLPLLA--MEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 140 Query: 156 YIHSANVLHRDLKPSNLLINTTCDL---KICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 Y+H ++HRDLKP N+++ KI D G A+ E D T +V T Y A Sbjct: 141 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAK----ELDQGSLCTSFVGTLQYLA 196 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSN-RPIFPG 247 PE +L + YT ++D WS G + E ++ RP P Sbjct: 197 PE-LLEQQKYTVTVDYWSFGTLAFECITGFRPFLPN 231 >4D2V-A nrPDB Length = 356 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 87/322 (27%), Positives = 139/322 (43%), Gaps = 44/322 (13%) Query: 36 FDVGPRYTQL-QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 +D +Y +L + IG G + V A + VAIK + + R EI+ L Sbjct: 24 YDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKN 83 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ-QLSNDHICYFLYQILR 152 RH+++ + +L E +++V + +L+ + SQ +LS + QI+ Sbjct: 84 LRHQHICQLYHVL-----ETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVS 138 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 + Y+HS HRDLKP NLL + LK+ DFGL A P+ + L Y A Sbjct: 139 AVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLC--AKPKGNKDYHLQACCGALAYAA 196 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++ D+WS+G +L ++ G L P +D Sbjct: 197 PELIQGKSYLGSEADVWSMGILLYVLMC------------------GFL--PFDDDTAAA 236 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 + K +P W L P S + LL +ML +P KRI+++ L HP++ Q Sbjct: 237 LVAKIMRGKYDVPK-----W--LSPSS----ILLLQQMLQVDPKKRISMKNLLNHPWIMQ 285 Query: 333 YYDPTDEPVAEEPFTFAMELDD 354 Y+ E ++ PF + LDD Sbjct: 286 DYNYPVEWQSKNPF---IHLDD 304 >2WQN-A nrPDB Length = 310 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 69/250 (27%), Positives = 115/250 (46%), Gaps = 39/250 (15%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT--LREIQILLRFRHENVIGIRD 105 IG G + V A + VA+KK+ F+ R ++EI +L + H NVI Sbjct: 40 IGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIK--- 96 Query: 106 ILRASTLEAMRDVYIVQDLMET-DLYKLLK-----SQQLSNDHICYFLYQILRGLKYIHS 159 AS +E ++ IV +L + DL +++K + + + + Q+ L+++HS Sbjct: 97 -YYASFIED-NELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHS 154 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 V+HRD+KP+N+ I T +K+ D GL R + T V T +Y +PE ++ Sbjct: 155 RRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSK---TTAAHSLVGTPYYMSPE-RIHE 210 Query: 220 KGYTKSIDIWSVGCILAEMLS----------------------NRPIFPGKHYLDQLNHI 257 GY DIWS+GC+L EM + + P P HY ++L + Sbjct: 211 NGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQL 270 Query: 258 LGILGSPSQE 267 + + +P E Sbjct: 271 VNMCINPDPE 280 >4KS7-A nrPDB Length = 292 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 76/286 (26%), Positives = 128/286 (44%), Gaps = 39/286 (13%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 IGEG+ G+V A + +VA+K + Q + E+ I+ ++H NV+ + Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMD-LRKQQRRELLFNEVVIMRDYQHFNVVE----M 85 Query: 108 RASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDL 167 S L +++ L L ++ +L+ + I +L+ L Y+H+ V+HRD+ Sbjct: 86 YKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDI 145 Query: 168 KPSNLLINTTCDLKICDFGL-ARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSI 226 K ++L+ +K+ DFG A+I+ V T ++ APE++ S Y + Sbjct: 146 KSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSL----VGTPYWMAPEVISRSL-YATEV 200 Query: 227 DIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPS 286 DIWS+G ++ EM+ P ++ D SP Q + S P Sbjct: 201 DIWSLGIMVIEMVDGEP----PYFSD----------SPVQ---------AMKRLRDSPPP 237 Query: 287 KTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 K K + K D L+RML +P +R T +E L HP+L Q Sbjct: 238 KLKNSH-----KVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ 278 >4LG4-A nrPDB Length = 299 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 87/319 (27%), Positives = 140/319 (43%), Gaps = 65/319 (20%) Query: 26 GEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT 85 GE + K QP +V + L+ +GEG+YG V A VAIK++ P E Q Sbjct: 1 GEDSLTK-QPEEV---FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESD--LQEI 53 Query: 86 LREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME----TDLYKLLKSQQLSND 141 ++EI I+ + V+ +T D++IV + +D+ +L +++ L D Sbjct: 54 IKEISIMQQCDSPYVVKYYGSYFKNT-----DLWIVMEYCGAGSVSDIIRL-RNKTLIED 107 Query: 142 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFL 201 I L L+GL+Y+H +HR++K N+L+NT K+ DFG+A G L Sbjct: 108 EIATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVA----------GQL 157 Query: 202 TEYVATR-------WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 T+ +A R ++ APE+ + GY DIWS+G EM +P + H + Sbjct: 158 TDTMAKRNTVIGTPFWMAPEV-IQEIGYNCVADIWSLGITSIEMAEGKPPYADIH---PM 213 Query: 255 NHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVA-WAKLFPKSDSKALDLLDRMLTF 313 I I +P P+ K W+ F D + + L Sbjct: 214 RAIFMIPTNPP-------------------PTFRKPELWSDDF-------TDFVKKCLVK 247 Query: 314 NPNKRITVEEALAHPYLEQ 332 NP +R T + L HP+++ Sbjct: 248 NPEQRATATQLLQHPFIKN 266 >4XBR-A nrPDB Length = 366 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 70/291 (24%), Positives = 125/291 (42%), Gaps = 39/291 (13%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 IGEG+ G+V A VA+KK+ Q + E+ I+ ++HENV+ + + Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMD-LRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 160 Query: 108 RASTLEAMRDVYIVQDLMETD-LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRD 166 ++++V + +E L ++ +++ + I +L+ L +H+ V+HRD Sbjct: 161 LVGD-----ELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 215 Query: 167 LKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSI 226 +K ++L+ +K+ DFG E L V T ++ APE +++ Y + Sbjct: 216 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSL---VGTPYWMAPE-LISRLPYGPEV 271 Query: 227 DIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPS 286 DIWS+G ++ EM+ P + + L + I +LP Sbjct: 272 DIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI-----------------------RDNLPP 308 Query: 287 KTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 + K K LDR+L +P +R T E L HP+L + P Sbjct: 309 RLKN-----LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 354 >2XNP-A nrPDB Length = 279 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 70/221 (31%), Positives = 111/221 (50%), Gaps = 29/221 (13%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKT--RVAIKKISPFEHQTYCQRTL--REIQILLRFRH 97 Y L IG G+YG RK+ ++ + K + T ++ + E+ +L +H Sbjct: 8 YEVLYTIGTGSYGRCQKIR---RKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH 64 Query: 98 ENVIGIRD--ILRASTLEAMRDVYIVQDLMET-DLYKLL-----KSQQLSNDHICYFLYQ 149 N++ D I R +T +YIV + E DL ++ + Q L + + + Q Sbjct: 65 PNIVRYYDRIIDRTNT-----TLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQ 119 Query: 150 ILRGLKYIHSAN-----VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEY 204 + LK H + VLHRDLKP+N+ ++ ++K+ DFGLARI + HD T F + Sbjct: 120 LTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILN--HD-TSFAKTF 176 Query: 205 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 V T +Y +PE M N Y + DIWS+GC+L E+ + P F Sbjct: 177 VGTPYYMSPEQM-NRMSYNEKSDIWSLGCLLYELCALMPPF 216 >4CFH-A nrPDB Length = 493 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 87/322 (27%), Positives = 137/322 (42%), Gaps = 53/322 (16%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 +G G +G V + +VA+K ++ + REIQ L FRH ++I + Sbjct: 41 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 100 Query: 106 ILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 ++ + D+++V + + +L+ + K+ +L QIL G+ Y H V+ Sbjct: 101 VISTPS-----DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVV 155 Query: 164 HRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 HRDLKP N+L++ + KI DFGL+ ++D E FL + Y APE++ Sbjct: 156 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGE-----FLRTSCGSPNYAAPEVISGRLYA 210 Query: 223 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL-GILGSPSQEDLNCIINMKARNYL 281 +DIWS G IL +L F H I GI +P YL Sbjct: 211 GPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTP--------------QYL 256 Query: 282 QSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPV 341 PS + LL ML +P KR T+++ H + +Q D Sbjct: 257 N--PS----------------VISLLKHMLQVDPMKRATIKDIREHEWFKQ--DLPKYLF 296 Query: 342 AEEPFTFAMELDDLPKERLKEL 363 E+P + +DD E LKE+ Sbjct: 297 PEDPSYSSTMIDD---EALKEV 315 >4CQG-A nrPDB Length = 331 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 87/309 (28%), Positives = 134/309 (43%), Gaps = 42/309 (13%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 Y + IG G + V A + VAIK + + R EI L RH+++ Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHIC 70 Query: 102 GIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ-QLSNDHICYFLYQILRGLKYIHS 159 + +L E +++V + +L+ + SQ +LS + QIL + Y+HS Sbjct: 71 QLYHVL-----ETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHS 125 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 HRDLKP NLL + LK+ DFGL A P+ + L E + Y APE++ Sbjct: 126 QGYAHRDLKPENLLFDENHKLKLIDFGLC--AKPKGNKDYHLQECCGSLAYAAPELIQGK 183 Query: 220 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN 279 D+WS+G +L ++ G L P +D N+ A Sbjct: 184 SYLGSEADVWSMGILLYVLMC------------------GFL--PFDDD-----NVMAL- 217 Query: 280 YLQSLPSKTKV-AWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTD 338 Y + + K +V W L P S + LL +ML +P KRI++ L HP++ Q Y Sbjct: 218 YKKIMRGKYEVPKW--LSPSS----ILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPV 271 Query: 339 EPVAEEPFT 347 E ++ P T Sbjct: 272 EWQSKTPLT 280 >6AO5-A nrPDB Length = 362 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 84/310 (27%), Positives = 136/310 (43%), Gaps = 64/310 (20%) Query: 34 QPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILL 93 QP +V + L+ +GEG+YG V A VAIK++ P E Q ++EI I+ Sbjct: 7 QPEEV---FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESD--LQEIIKEISIMQ 60 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLME----TDLYKLLKSQQLSNDHICYFLYQ 149 + V+ +T D++IV + +D+ +L +++ L D I L Sbjct: 61 QCDSPYVVKYYGSYFKNT-----DLWIVMEYCGAGSVSDIIRL-RNKTLIEDEIATILKS 114 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR- 208 L+GL+Y+H +HR++K N+L+NT K+ DFG+A G LT+ +A R Sbjct: 115 TLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVA----------GQLTDTMAKRN 164 Query: 209 ------WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILG 262 ++ APE+ + GY DIWS+G EM +P + H + I I Sbjct: 165 TVIGTPFWMAPEV-IQEIGYNCVADIWSLGITSIEMAEGKPPYADIH---PMRAIFMIPT 220 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTKVA-WAKLFPKSDSKALDLLDRMLTFNPNKRITV 321 +P P+ K W+ F D + + L NP +R T Sbjct: 221 NPP-------------------PTFRKPELWSDDF-------TDFVKKCLVKNPEQRATA 254 Query: 322 EEALAHPYLE 331 + L HP+++ Sbjct: 255 TQLLQHPFIK 264 >3LM0-A nrPDB Length = 327 Score = 84.3 bits (207), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 64/203 (31%), Positives = 100/203 (49%), Gaps = 37/203 (18%) Query: 135 SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT---CDLKICDFGLARIA 191 ++ +S + + + QIL G+ Y+H N++H DLKP N+L+++ D+KI DFG++R Sbjct: 125 AEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSR-- 182 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 251 + H L E + T Y APEI LN T + D+W++G I+A ML Sbjct: 183 --KIGHACELREIMGTPEYLAPEI-LNYDPITTATDMWNIG-IIAYML------------ 226 Query: 252 DQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWA-KLFPKSDSKALDLLDRM 310 L H +G +QE YL S+ V ++ + F A D + + Sbjct: 227 --LTHTSPFVGEDNQE-----------TYLN--ISQVNVDYSEETFSSVSQLATDFIQSL 271 Query: 311 LTFNPNKRITVEEALAHPYLEQY 333 L NP KR T E L+H +L+Q+ Sbjct: 272 LVKNPEKRPTAEICLSHSWLQQW 294 >4REW-A nrPDB Length = 540 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 86/322 (26%), Positives = 137/322 (42%), Gaps = 53/322 (16%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 +G G +G V + +VA+K ++ + REIQ L FRH ++I + Sbjct: 14 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 73 Query: 106 ILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 ++ + D+++V + + +L+ + K+ +L QIL G+ Y H V+ Sbjct: 74 VISTPS-----DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVV 128 Query: 164 HRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 HRDLKP N+L++ + KI DFGL+ ++D E FL + Y APE++ Sbjct: 129 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGE-----FLRTSCGSPNYAAPEVISGRLYA 183 Query: 223 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL-GILGSPSQEDLNCIINMKARNYL 281 +DIWS G IL +L F H I GI +P YL Sbjct: 184 GPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTP--------------QYL 229 Query: 282 QSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPV 341 PS + LL ML +P KR ++++ H + +Q D Sbjct: 230 N--PS----------------VISLLKHMLQVDPMKRASIKDIREHEWFKQ--DLPKYLF 269 Query: 342 AEEPFTFAMELDDLPKERLKEL 363 E+P + +DD E LKE+ Sbjct: 270 PEDPSYSSTMIDD---EALKEV 288 >4FZF-B nrPDB Length = 283 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 100/203 (49%), Gaps = 10/203 (4%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 +T+L+ IG+G++G V D+ + VAIK I E + + +EI +L + V Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 69 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSAN 161 S L+ + I++ L LL++ I L +IL+GL Y+HS Sbjct: 70 K----YYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEK 125 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLA-RIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 +HRD+K +N+L++ D+K+ FG+A ++ D + F V T ++ APE++ S Sbjct: 126 KIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTF----VGTPFWMAPEVIQQS- 180 Query: 221 GYTKSIDIWSVGCILAEMLSNRP 243 Y DIWS+G E+ P Sbjct: 181 AYDSKADIWSLGITAIELAKGEP 203 >5MJB-A nrPDB Length = 305 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 65/220 (29%), Positives = 103/220 (46%), Gaps = 20/220 (9%) Query: 46 QYIGEGAYGMVSSAYDHV---RKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 + IG G +G V + R+ VAIK + + + L E I+ +F H N+I Sbjct: 32 EVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRNIIR 91 Query: 103 IRDILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159 + ++ S R V I+ + ME D + Q + + L I G+KY+ Sbjct: 92 LEGVVTKS-----RPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSE 146 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHD--HTGFLTEYVATRWYRAPEIM 216 N +HRDL N+L+N+ K+ DFGL+R + D D +T L + RW APE + Sbjct: 147 MNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW-TAPEAI 205 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 K +T + D+WS G ++ E++S F + Y D N Sbjct: 206 AYRK-FTSASDVWSYGIVMWEVMS----FGERPYWDMSNQ 240 >6CCF-A nrPDB Length = 290 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 75/318 (23%), Positives = 137/318 (43%), Gaps = 63/318 (19%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-------------------------SP 75 +Y IG+GAYG+V AY+ A+K + P Sbjct: 6 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGP 65 Query: 76 FEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLK 134 + +R +EI IL + H NV+ + ++L A ++Y+V DL+ + ++ Sbjct: 66 AKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDP---AEDNLYLVFDLLRKGPVMEVPC 122 Query: 135 SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPE 194 + S + +L ++ GL+Y+H ++HRD+KPSNLL+ +KI DFG +++ Sbjct: 123 DKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFG---VSNQF 179 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNS-KGYT-KSIDIWSVGCILAEMLSNRPIFPGKHYLD 252 + L+ T + APE + +S + ++ K++D+W+ G L + + Sbjct: 180 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGK---------- 229 Query: 253 QLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLT 312 P +D ++ K +N P + P+ + DL+ +ML Sbjct: 230 ----------CPFIDDFILALHRKIKNEPVVFPEE---------PEISEELKDLILKMLD 270 Query: 313 FNPNKRITVEEALAHPYL 330 NP RI V + HP++ Sbjct: 271 KNPETRIGVPDIKLHPWV 288 >1ZWS-A nrPDB Length = 288 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 72/253 (28%), Positives = 115/253 (45%), Gaps = 49/253 (19%) Query: 87 REIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLL-KSQQLSNDHIC 144 RE+ IL + H NVI + D+ T DV ++ +L+ +L+ L + + LS + Sbjct: 64 REVSILRQVLHHNVITLHDVYENRT-----DVVLILELVSGGELFDFLAQKESLSEEEAT 118 Query: 145 YFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC----DLKICDFGLARIADPEHDHTGF 200 F+ QIL G+ Y+H+ + H DLKP N+++ +K+ DFGLA + D F Sbjct: 119 SFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIE---DGVEF 175 Query: 201 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI 260 + T + APEI+ N + D+WS+G I +LS F Sbjct: 176 KNIF-GTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPF--------------- 218 Query: 261 LGSPSQEDLNCIINMKARNYLQSLPSKTKVAW---AKLFPKSDSKALDLLDRMLTFNPNK 317 LG QE L I T V++ + F + A D + ++L K Sbjct: 219 LGDTKQETLANI---------------TSVSYDFDEEFFSHTSELAKDFIRKLLVKETRK 263 Query: 318 RITVEEALAHPYL 330 R+T++EAL HP++ Sbjct: 264 RLTIQEALRHPWI 276 >4YNZ-A nrPDB Length = 342 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 83/322 (25%), Positives = 144/322 (44%), Gaps = 47/322 (14%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFR 96 VGP Y + +G+G G+V V +VAIK ++ + ++ + REI IL Sbjct: 9 VGP-YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIE 67 Query: 97 HENVIGIRDILRASTLEAMRDVYIV-QDLMETDLYK-LLKSQQLSNDHICYFLYQILRGL 154 H +V+ + D+ E + +Y+V + + +L+ L+K +L+ F QI+ L Sbjct: 68 HPHVLKLHDVY-----ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 122 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 + HS ++ HRDLKP NLL++ +++I DFG+A + + L + Y PE Sbjct: 123 DFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGD----SLLETSCGSPHYACPE 178 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 ++ K + D+WS G IL +L +G+ +D N Sbjct: 179 VIRGEKYDGRKADVWSCGVILFALL---------------------VGALPFDDDN---- 213 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 334 R L+ + K V F D ++ LL M+ + +R+T+E H + Y Sbjct: 214 --LRQLLEKV--KRGVFHMPHFIPPDCQS--LLRGMIEVDAARRLTLEHIQKHIW---YI 264 Query: 335 DPTDEPVAEEPFTFAMELDDLP 356 +EP E+P +++ LP Sbjct: 265 GGKNEPEPEQPIPRKVQIRSLP 286 >2A27-A nrPDB Length = 321 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 72/253 (28%), Positives = 116/253 (45%), Gaps = 49/253 (19%) Query: 87 REIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLL-KSQQLSNDHIC 144 RE+ IL + H NVI + D+ T DV ++ +L+ +L+ L + + LS + Sbjct: 64 REVSILRQVLHHNVITLHDVYENRT-----DVVLILELVSGGELFDFLAQKESLSEEEAT 118 Query: 145 YFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC----DLKICDFGLARIADPEHDHTGF 200 F+ QIL G+ Y+H+ + H DLKP N+++ +K+ DFGLA + D F Sbjct: 119 SFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIE---DGVEF 175 Query: 201 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI 260 + T + APEI+ N + D+WS+G I +LS F Sbjct: 176 KNIF-GTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPF--------------- 218 Query: 261 LGSPSQEDLNCIINMKARNYLQSLPSKTKVAW---AKLFPKSDSKALDLLDRMLTFNPNK 317 LG QE L I T V++ + F ++ A D + ++L K Sbjct: 219 LGDTKQETLANI---------------TAVSYDFDEEFFSQTSELAKDFIRKLLVKETRK 263 Query: 318 RITVEEALAHPYL 330 R+T++EAL HP++ Sbjct: 264 RLTIQEALRHPWI 276 >2H8H-A nrPDB Length = 535 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 105/215 (48%), Gaps = 20/215 (9%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G+G +G V + TRVAIK + P + L+E Q++ + RHE ++ + ++ Sbjct: 275 LGQGCFGEVWMGTWN-GTTRVAIKTLKPGTMSP--EAFLQEAQVMKKLRHEKLVQLYAVV 331 Query: 108 RASTLEAMRDVYIVQDLMET----DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 + +YIV + M D K + L + QI G+ Y+ N + Sbjct: 332 ------SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 385 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 223 HRDL+ +N+L+ K+ DFGLAR+ + ++++T +W APE L + +T Sbjct: 386 HRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKW-TAPEAALYGR-FT 442 Query: 224 KSIDIWSVGCILAEMLS-NRPIFPG---KHYLDQL 254 D+WS G +L E+ + R +PG + LDQ+ Sbjct: 443 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 477 >2JD5-A nrPDB Length = 373 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 87/337 (25%), Positives = 148/337 (43%), Gaps = 47/337 (13%) Query: 32 KGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQI 91 KG+P+ RY ++ +G G + V A D V T VA+K + + Y + EI++ Sbjct: 12 KGEPYK-DARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRG--DKVYTEAAEDEIKL 68 Query: 92 LLRFR-----HENVIGIRDILRASTLEAMRD-----VYIVQDLMETDLYKLLKSQQLSND 141 L R E+ +G IL+ + V +V +++ +L L+K + Sbjct: 69 LQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGI 128 Query: 142 HICY---FLYQILRGLKYIHS-ANVLHRDLKPSNLLINTT------CDLKICDFGLARIA 191 + Y Q+L GL Y+H ++H D+KP N+L+ +KI D G A Sbjct: 129 PLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY 188 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF---PGK 248 D EH T + TR YR+PE++L + + DIWS C++ E+++ +F G Sbjct: 189 D-EH-----YTNSIQTREYRSPEVLLGAP-WGCGADIWSTACLIFELITGDFLFEPDEGH 241 Query: 249 HYLDQLNHILGIL-------------GSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKL 295 Y +HI I+ G ++ N ++ + L+ P + + Sbjct: 242 SYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYK 301 Query: 296 FPKSDSKAL-DLLDRMLTFNPNKRITVEEALAHPYLE 331 F K ++K + D L ML +P KR + HP+L+ Sbjct: 302 FSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLK 338 >2QNJ-A nrPDB Length = 328 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 71/292 (24%), Positives = 132/292 (45%), Gaps = 43/292 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENV 100 Y L+ IG+G + V A + VAIK I + + T Q+ RE++I+ H N+ Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 73 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ-QLSNDHICYFLYQILRGLKYIH 158 + + +++ E + +Y++ + +++ L + ++ QI+ ++Y H Sbjct: 74 VKLFEVI-----ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 128 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 ++HRDLK NLL++ ++KI DFG + E G L + + Y APE+ Sbjct: 129 QKRIVHRDLKAENLLLDADMNIKIADFGFSN----EFTVGGKLDTFCGSPPYAAPELFQG 184 Query: 219 SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKAR 278 K +D+WS+G IL ++S F G++ L +L Sbjct: 185 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQN-LKELRE---------------------- 221 Query: 279 NYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + L K ++ + + +D + +LL R L NP KR T+E+ + ++ Sbjct: 222 ---RVLRGKYRIPF---YMSTDCE--NLLKRFLVLNPIKRGTLEQIMKDRWI 265 >2YAB-A nrPDB Length = 361 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 84/311 (27%), Positives = 137/311 (44%), Gaps = 64/311 (20%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI----SPFEHQTYCQRTL-REIQ 90 +D+G + +G G + +V + A K I S + C+ + RE+ Sbjct: 14 YDIG------EELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVS 67 Query: 91 ILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLL-KSQQLSNDHICYFLY 148 IL + H N+I + D+ T DV ++ +L+ +L+ L + + LS + F+ Sbjct: 68 ILRQVLHPNIITLHDVYENRT-----DVVLILELVSGGELFDFLAQKESLSEEEATSFIK 122 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTC----DLKICDFGLA-RIADPEHDHTGFLT- 202 QIL G+ Y+H+ + H DLKP N+++ +K+ DFGLA I D F T Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP 182 Query: 203 EYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILG 262 E+V APEI+ N + D+WS+G I +LS F LG Sbjct: 183 EFV------APEIV-NYEPLGLEADMWSIGVITYILLSGASPF---------------LG 220 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTKVAW---AKLFPKSDSKALDLLDRMLTFNPNKRI 319 QE L I T V++ + F ++ A D + ++L KR+ Sbjct: 221 DTKQETLANI---------------TAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRL 265 Query: 320 TVEEALAHPYL 330 T++EAL HP++ Sbjct: 266 TIQEALRHPWI 276 >4RED-A nrPDB Length = 351 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 86/322 (26%), Positives = 135/322 (41%), Gaps = 53/322 (16%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 +G G +G V + VA+K ++ + REIQ L FRH ++I + Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 106 ILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 ++ + D+++V + + +L+ + K+ +L QIL G+ Y H V+ Sbjct: 82 VISTPS-----DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVV 136 Query: 164 HRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 HRDLKP N+L++ + KI DFGL+ ++D E FL + Y APE++ Sbjct: 137 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGE-----FLRTSCGSPNYAAPEVISGRLYA 191 Query: 223 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL-GILGSPSQEDLNCIINMKARNYL 281 +DIWS G IL +L F H I GI +P YL Sbjct: 192 GPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTP--------------QYL 237 Query: 282 QSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPV 341 PS + LL ML +P KR ++++ H + +Q D Sbjct: 238 N--PS----------------VISLLKHMLQVDPMKRASIKDIREHEWFKQ--DLPKYLF 277 Query: 342 AEEPFTFAMELDDLPKERLKEL 363 E+P +DD E LKE+ Sbjct: 278 PEDPSYSTTMIDD---EALKEV 296 >2X4F-A nrPDB Length = 373 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 83/320 (25%), Positives = 139/320 (43%), Gaps = 45/320 (14%) Query: 21 GPGVPGEVEMVKGQPFDVGPRYT--QLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEH 78 P P + +V + V YT + + +G G +G V + ++A K I Sbjct: 68 APPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGM 127 Query: 79 QTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLL--KS 135 + + EI ++ + H N+I + D E+ D+ +V + ++ +L+ + +S Sbjct: 128 KDK-EEVKNEISVMNQLDHANLIQLYD-----AFESKNDIVLVMEYVDGGELFDRIIDES 181 Query: 136 QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL-INTTC-DLKICDFGLARIADP 193 L+ F+ QI G++++H +LH DLKP N+L +N +KI DFGLAR P Sbjct: 182 YNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKP 241 Query: 194 EHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQ 253 L T + APE+ +N + D+WSVG I +LS F G + + Sbjct: 242 REK----LKVNFGTPEFLAPEV-VNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAET 296 Query: 254 LNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTF 313 LN+IL E+ I+ +A+ ++ L K K +W Sbjct: 297 LNNILACRWDLEDEEFQD-ISEEAKEFISKLLIKEK-SW--------------------- 333 Query: 314 NPNKRITVEEALAHPYLEQY 333 RI+ EAL HP+L + Sbjct: 334 ----RISASEALKHPWLSDH 349 >3UC3-A nrPDB Length = 361 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 62/202 (30%), Positives = 97/202 (48%), Gaps = 13/202 (6%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 100 RY ++ IG G +G+ D + K VA+K I + REI RH N+ Sbjct: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE--RGAAIDENVQREIINHRSLRHPNI 78 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLKYIHS 159 + ++++ T A+ I++ +LY ++ + + S D +F Q+L G+ Y HS Sbjct: 79 VRFKEVILTPTHLAI----IMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 Query: 160 ANVLHRDLKPSNLLINTTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 + HRDLK N L++ + LKICDFG ++ + H V T Y APE++L Sbjct: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSK-SSVLHSQP---KSTVGTPAYIAPEVLL 190 Query: 218 NSKGYTKSIDIWSVGCILAEML 239 + K D+WS G L ML Sbjct: 191 RQEYDGKIADVWSCGVTLYVML 212 >4M7I-A nrPDB Length = 299 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 57/219 (26%), Positives = 106/219 (48%), Gaps = 22/219 (10%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + +Q +G G +G+V A + V AIK+I + ++ +RE++ L + H ++ Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV 66 Query: 102 GIRDI-LRASTLEAMRD------VYIVQDLMETDLYKLLKSQQLSNDH----ICYFLY-Q 149 + L +T E ++ +YI L + K + + + + +C ++ Q Sbjct: 67 RYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQ 126 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEY----- 204 I ++++HS ++HRDLKPSN+ +K+ DFGL D + + LT Sbjct: 127 IAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYAR 186 Query: 205 ----VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239 V T+ Y +PE ++ Y+ +DI+S+G IL E+L Sbjct: 187 HTGQVGTKLYMSPE-QIHGNSYSHKVDIFSLGLILFELL 224 >2HK5-A nrPDB Length = 270 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 104/205 (50%), Gaps = 17/205 (8%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G G +G V A + + T+VA+K + P + L E ++ +H+ ++ + ++ Sbjct: 23 LGAGQFGEVWMA-TYNKHTKVAVKTMKP--GSMSVEAFLAEANVMKTLQHDKLVKLHAVV 79 Query: 108 RASTLEAMRDVYIVQDLM-ETDLYKLLKSQQLSND---HICYFLYQILRGLKYIHSANVL 163 +YI+ + M + L LKS + S + F QI G+ +I N + Sbjct: 80 ------TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYI 133 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 223 HRDL+ +N+L++ + KI DFGLAR+ + ++++T +W APE +N +T Sbjct: 134 HRDLRAANILVSASLVCKIADFGLARVIE-DNEYTAREGAKFPIKW-TAPE-AINFGSFT 190 Query: 224 KSIDIWSVGCILAEMLS-NRPIFPG 247 D+WS G +L E+++ R +PG Sbjct: 191 IKSDVWSFGILLMEIVTYGRIPYPG 215 >3QA8-A nrPDB Length = 676 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 70/226 (30%), Positives = 103/226 (45%), Gaps = 28/226 (12%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKK----ISPFEHQTYCQRTLREIQILL 93 GP + + +G G +G V +VAIK+ +SP + +C EIQI+ Sbjct: 13 CGP-WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWC----LEIQIMK 67 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLME----TDLYKLLKSQQ----LSNDHICY 145 + H NV+ R++ A D+ ++ ME DL K L + L I Sbjct: 68 KLNHPNVVSAREVPDGLQKLAPNDLPLLA--MEYCEGGDLRKYLNQFENCCGLKEGPIRT 125 Query: 146 FLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL---KICDFGLARIADPEHDHTGFLT 202 L I L+Y+H ++HRDLKP N+++ KI D G A+ E D T Sbjct: 126 LLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAK----ELDQGELCT 181 Query: 203 EYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN-RPIFPG 247 E+V T Y APE +L K YT ++D WS G + E ++ RP P Sbjct: 182 EFVGTLQYLAPE-LLEQKKYTVTVDYWSFGTLAFECITGFRPFLPN 226 >1FOT-A nrPDB Length = 318 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 49/151 (32%), Positives = 85/151 (56%), Gaps = 9/151 (5%) Query: 111 TLEAMRDVYIVQDLMET-DLYKLL-KSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLK 168 T + + ++++ D +E +L+ LL KSQ+ N ++ ++ L+Y+HS ++++RDLK Sbjct: 74 TFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLK 133 Query: 169 PSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDI 228 P N+L++ +KI DFG A+ P+ +T T Y APE+ +++K Y KSID Sbjct: 134 PENILLDKNGHIKITDFGFAKYV-PDVTYT-----LCGTPDYIAPEV-VSTKPYNKSIDW 186 Query: 229 WSVGCILAEMLSNRPIFPGKHYLDQLNHILG 259 WS G ++ EML+ F + + IL Sbjct: 187 WSFGILIYEMLAGYTPFYDSNTMKTYEKILN 217 >5J5T-A nrPDB Length = 370 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 80/295 (27%), Positives = 125/295 (42%), Gaps = 43/295 (14%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIK--KISPFEHQTYCQRTLREIQILLRFRHENVIG 102 +Q IG G YG V A + AIK K+ P E Q+ EI ++ +H N++ Sbjct: 9 IQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ---EIIMMKDCKHPNIVA 65 Query: 103 -IRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSAN 161 LR L + L D+Y + + LS I Y + L+GL Y+HS Sbjct: 66 YFGSYLRRDKLWICMEFCGGGSLQ--DIYHV--TGPLSELQIAYVSRETLQGLYYLHSKG 121 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGL-ARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 +HRD+K +N+L+ +K+ DFG+ A+I F + T ++ APE+ + Sbjct: 122 KMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAF----IGTPYWMAPEVAAVER 177 Query: 221 --GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKAR 278 GY + D+W+VG E+ +P H + + M Sbjct: 178 KGGYNQLCDLWAVGITAIELAELQPPMFDLH------------------PMRALFLMTKS 219 Query: 279 NYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 N+ Q K K+ W+ F + LT NP KR T E+ L HP++ Q+ Sbjct: 220 NF-QPPKLKDKMKWSNSFHH-------FVKMALTKNPKKRPTAEKLLQHPFVTQH 266 >5L6P-A nrPDB Length = 298 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 65/220 (29%), Positives = 103/220 (46%), Gaps = 20/220 (9%) Query: 46 QYIGEGAYGMVSSA---YDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 + IG G +G V R+ VAIK + + + L E I+ +F H N+I Sbjct: 25 EVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIR 84 Query: 103 IRDILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159 + ++ S R V I+ + ME D + L Q + + L I G+KY+ Sbjct: 85 LEGVVTKS-----RPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSE 139 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIA--DP-EHDHTGFLTEYVATRWYRAPEIM 216 N +HRDL N+L+N+ K+ DFGL+R DP + +T L + RW APE + Sbjct: 140 MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRW-TAPEAI 198 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 K +T + D+WS G ++ E++S + + Y D N Sbjct: 199 AYRK-FTSASDVWSYGIVMWEVMS----YGERPYWDMSNQ 233 >6F3F-A nrPDB Length = 455 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 62/215 (28%), Positives = 105/215 (48%), Gaps = 20/215 (9%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G+G +G V + TRVAIK + P + L+E Q++ + RHE ++ + ++ Sbjct: 195 LGQGCFGEVWMGTWN-GTTRVAIKTLKPGTMSP--EAFLQEAQVMKKLRHEKLVQLYAVV 251 Query: 108 RASTLEAMRDVYIVQDLMET----DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 + +YIV + M D K + L + QI G+ Y+ N + Sbjct: 252 ------SEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYV 305 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 223 HRDL+ +N+L+ K+ DFGLAR+ + ++++T +W APE L + Sbjct: 306 HRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKW-TAPEAALYGRFTI 363 Query: 224 KSIDIWSVGCILAEMLS-NRPIFPG---KHYLDQL 254 KS D+WS G +L E+ + R +PG + LDQ+ Sbjct: 364 KS-DVWSFGILLTELTTKGRVPYPGMVNREVLDQV 397 >5D7A-A nrPDB Length = 308 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 73/296 (24%), Positives = 122/296 (41%), Gaps = 44/296 (14%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF-RHENVIGI 103 ++ +G G YG V HV+ ++A K+ + +EI +L ++ H N+ Sbjct: 22 VELVGNGTYGQVYKGR-HVKTGQLAAIKVMDVTGDEE-EEIKQEINMLKKYSHHRNIATY 79 Query: 104 RDILRASTLEAMRD-VYIVQDLME----TDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 M D +++V + TDL K K L + I Y +ILRGL ++H Sbjct: 80 YGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLH 139 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 V+HRD+K N+L+ ++K+ DFG++ D G ++ T ++ APE++ Sbjct: 140 QHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT---VGRRNTFIGTPYWMAPEVIAC 196 Query: 219 SKG----YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 + Y D+WS+G EM P H + L I Sbjct: 197 DENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLI----------------- 239 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 RN L SK W+K F ++ L N ++R E+ + HP++ Sbjct: 240 --PRNPAPRLKSKK---WSKKFQ-------SFIESCLVKNHSQRPATEQLMKHPFI 283 >5SYS-A nrPDB Length = 286 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 104/217 (47%), Gaps = 20/217 (9%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G+G +G + TRVAIK + P + L+E Q++ + RHE ++ + ++ Sbjct: 26 LGQGCFGECWMGTWN-GTTRVAIKTLKPGTMSP--EAFLQEAQVMKKLRHEKLVQLYAVV 82 Query: 108 RASTLEAMRDVYIVQDLMET----DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 + +YIV + M D K + L + QI G+ Y+ N + Sbjct: 83 ------SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYV 136 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 223 HRDL+ +N+L+ K+ DFGLAR+ + ++++T +W APE L + Sbjct: 137 HRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKW-TAPEAALYGRFTI 194 Query: 224 KSIDIWSVGCILAEMLS-NRPIFPG---KHYLDQLNH 256 KS D+WS G +L E+ + R +PG + LDQ+ Sbjct: 195 KS-DVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 230 >2RIO-A nrPDB Length = 434 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 78/278 (28%), Positives = 124/278 (44%), Gaps = 61/278 (21%) Query: 81 YCQRTLREIQILLRFR-HENVIGIRDILRASTLEAM-RDVYIVQDLMETDLYKLLKSQQL 138 +C L EI++L H NVI R E R +YI +L +L L++S+ + Sbjct: 51 FCDIALMEIKLLTESDDHPNVI------RYYCSETTDRFLYIALELCNLNLQDLVESKNV 104 Query: 139 SNDHI--------CYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLK--------- 181 S++++ L QI G+ ++HS ++HRDLKP N+L++T+ Sbjct: 105 SDENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAEN 164 Query: 182 ----ICDFGLARIADP-EHDHTGFLTEYVATRWYRAPEIMLNSKG------YTKSIDIWS 230 I DFGL + D + L T +RAPE++ S T+SIDI+S Sbjct: 165 LRILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFS 224 Query: 231 VGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKV 290 +GC+ +LS G Y + N I GI S +++ C L ++ + Sbjct: 225 MGCVFYYILSKGKHPFGDKYSRESNIIRGIF---SLDEMKC------------LHDRSLI 269 Query: 291 AWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 328 A +A DL+ +M+ +P KR T + L HP Sbjct: 270 A----------EATDLISQMIDHDPLKRPTAMKVLRHP 297 >5X5O-A nrPDB Length = 310 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 108/227 (47%), Gaps = 29/227 (12%) Query: 30 MVKGQPFDVGPRYTQLQYI---GEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTL 86 M G F V ++ LQ+ G G++G V A + VA+KK+ E Sbjct: 3 MGSGASF-VQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE--------- 52 Query: 87 REIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL---KSQQLSNDHI 143 +E +IL H N+I ++ LE + + LY + +S+++ DHI Sbjct: 53 KEAEILSVLSHRNIIQFYGVI----LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHI 108 Query: 144 CYFLYQILRGLKYIHS---ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGF 200 + + +G+ Y+H V+HRDLK N++I LKICDFG +R H+HT Sbjct: 109 MTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF----HNHTTH 164 Query: 201 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 247 ++ V T + APE+ + S +++ D +S G +L EML+ F G Sbjct: 165 MS-LVGTFPWMAPEV-IQSLPVSETCDTYSYGVVLWEMLTREVPFKG 209 >4B8L-A nrPDB Length = 286 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 75/301 (24%), Positives = 128/301 (42%), Gaps = 54/301 (17%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILL 93 FD+G + +G+G +G V A + K +A+K + S E + + REI+I Sbjct: 17 FDIG------RPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQS 70 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYK-LLKSQQLSNDHICYFLYQIL 151 RH N++ + + + +Y++ + +LYK L K + F+ ++ Sbjct: 71 HLRHPNILRMYNYFHDR-----KRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELA 125 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 L Y H V+HRD+KP NLL+ +LKI DFG + A T T Y Sbjct: 126 DALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRT-----MCGTLDYL 180 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ-EDLN 270 PE M+ K + + +D+W G + E L P F SPS E Sbjct: 181 PPE-MIEGKTHDEKVDLWCAGVLCYEFLVGMPPF----------------DSPSHTETHR 223 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 I+N+ K P + DL+ ++L ++P +R+ ++ + HP++ Sbjct: 224 RIVNVD----------------LKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWV 267 Query: 331 E 331 + Sbjct: 268 K 268 >3A4O-X nrPDB Length = 286 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 59/215 (27%), Positives = 106/215 (49%), Gaps = 16/215 (7%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G G +G V Y + T+VA+K + P Q L E ++ +H+ ++ + ++ Sbjct: 21 LGAGQFGEVWMGY-YNNSTKVAVKTLKP--GTMSVQAFLEEANLMKTLQHDKLVRLYAVV 77 Query: 108 RASTLEAMRDVYIVQDLM-ETDLYKLLKSQQLSN---DHICYFLYQILRGLKYIHSANVL 163 +YI+ + M + L LKS + + F QI G+ YI N + Sbjct: 78 TRE-----EPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 132 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 223 HRDL+ +N+L++ + KI DFGLAR+ + ++++T +W APE +N +T Sbjct: 133 HRDLRAANVLVSESLMCKIADFGLARVIE-DNEYTAREGAKFPIKW-TAPE-AINFGCFT 189 Query: 224 KSIDIWSVGCILAEMLSNRPI-FPGKHYLDQLNHI 257 D+WS G +L E+++ I +PG+ D + + Sbjct: 190 IKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTAL 224 >5UIU-A nrPDB Length = 323 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 99/211 (46%), Gaps = 8/211 (3%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQT---YCQRTLREIQIL 92 FD P +GEG +G+V Y V T VA+KK++ T Q+ +EI+++ Sbjct: 43 FDERPISVGGNKMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKVM 100 Query: 93 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILR 152 + +HEN++ + + VY+ + L L + LS C Sbjct: 101 AKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAAN 160 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 G+ ++H + +HRD+K +N+L++ KI DFGLAR A + T + V T Y A Sbjct: 161 GINFLHENHHIHRDIKSANILLDEAFTAKISDFGLAR-ASEKFAQTVMTSRIVGTTAYMA 219 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRP 243 PE + T DI+S G +L E+++ P Sbjct: 220 PEALRGE--ITPKSDIYSFGVVLLEIITGLP 248 >5H2U-A nrPDB Length = 267 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 68/219 (31%), Positives = 107/219 (48%), Gaps = 32/219 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRV--AIKKIS--PFEHQTYCQRTLREIQILLRFRH 97 +T + +G G +G V ++ + K RV AIK IS HQ Q EIQ + + RH Sbjct: 8 FTLCRKLGSGYFGEV---FEGLWKDRVQVAIKVISRDNLLHQQMLQS---EIQAMKKLRH 61 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ---LSNDHICYFLYQILRG 153 ++++ + ++ VYI+ +LM + L +LL+ L + +Q+ G Sbjct: 62 KHILALYAVVSVGD-----PVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEG 116 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPE----HDHTGFLTEYVATRW 209 + Y+ S N +HRDL N+L+ K+ DFGLAR+ + HDH + +W Sbjct: 117 MCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHN------IPYKW 170 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPI-FPG 247 APE + TKS D+WS G +L EM S + +PG Sbjct: 171 -TAPEALSRGHYSTKS-DVWSFGILLHEMFSRGQVPYPG 207 >5GRN-A nrPDB Length = 356 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 108/222 (48%), Gaps = 31/222 (13%) Query: 48 IGEGAYGMV--SSAYDHVRK---TRVAIKKISPFEHQTYCQRTLREIQILLRFR-HENVI 101 +G GA+G V +AY R +VA+K + P + Q + E++I+ H N++ Sbjct: 54 LGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIV 113 Query: 102 GIRDILRAST-----------------LEAMRDVYIV---QDLMETDLYKLL---KSQQL 138 + S L RD ++ + ++++++ LL S+ L Sbjct: 114 NLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGL 173 Query: 139 SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHT 198 + + F YQ+ RG++++ S N +HRDL N+L+ +KICDFGLAR + ++ Sbjct: 174 TLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYV 233 Query: 199 GFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + ++ +W APE + ++ YT D+WS G +L E+ S Sbjct: 234 SKGSTFLPVKW-MAPESIFDNL-YTTLSDVWSYGILLWEIFS 273 >5TQX-A nrPDB Length = 655 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 66/222 (29%), Positives = 100/222 (45%), Gaps = 20/222 (9%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95 F G + + +G G +G V ++AIK +R EIQI+ + Sbjct: 4 FGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKL 63 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLME----TDLYKLLKSQQ----LSNDHICYFL 147 H NV+ D+ + + DV ++ ME DL KLL + L I L Sbjct: 64 NHANVVKACDVPEELNI-LIHDVPLLA--MEYCSGGDLRKLLNKPENCCGLKESQILSLL 120 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDL---KICDFGLARIADPEHDHTGFLTEY 204 I G++Y+H ++HRDLKP N+++ KI D G A+ + D TE+ Sbjct: 121 SDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAK----DVDQGELCTEF 176 Query: 205 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN-RPIF 245 V T Y APE+ N K YT ++D WS G ++ E ++ RP Sbjct: 177 VGTLQYLAPELFEN-KPYTATVDYWSFGTMVFECIAGYRPFL 217 >2DQ7-X nrPDB Length = 283 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 107/218 (49%), Gaps = 17/218 (7%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 ++ +G G +G V + T+VAIK + P + L E QI+ + +H+ ++ + Sbjct: 14 IKRLGNGQFGEVWMGTWN-GNTKVAIKTLKPGTMSP--ESFLEEAQIMKKLKHDKLVQLY 70 Query: 105 DILRASTLEAMRDVYIVQDLMET----DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSA 160 ++ + +YIV + M D K + + L ++ Q+ G+ YI Sbjct: 71 AVV------SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 124 Query: 161 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 N +HRDL+ +N+L+ KI DFGLAR+ + ++++T +W APE L + Sbjct: 125 NYIHRDLRSANILVGNGLICKIADFGLARLIE-DNEYTARQGAKFPIKW-TAPEAALYGR 182 Query: 221 GYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHI 257 KS D+WS G +L E+++ R +PG + + L + Sbjct: 183 FTIKS-DVWSFGILLTELVTKGRVPYPGMNNREVLEQV 219 >2PL0-A nrPDB Length = 289 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 104/208 (50%), Gaps = 17/208 (8%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 ++ +G G +G V Y + T+VA+K + + L E ++ + +H+ ++ Sbjct: 28 VERLGAGQFGEVWMGY-YNGHTKVAVKSLK--QGSMSPDAFLAEANLMKQLQHQRLV--- 81 Query: 105 DILRASTLEAMRDVYIVQDLMET----DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSA 160 R + +YI+ + ME D K +L+ + + QI G+ +I Sbjct: 82 ---RLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEER 138 Query: 161 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 N +HRDL+ +N+L++ T KI DFGLAR+ + ++++T +W APE +N Sbjct: 139 NYIHRDLRAANILVSDTLSCKIADFGLARLIE-DNEYTAREGAKFPIKW-TAPE-AINYG 195 Query: 221 GYTKSIDIWSVGCILAEMLSNRPI-FPG 247 +T D+WS G +L E++++ I +PG Sbjct: 196 TFTIKSDVWSFGILLTEIVTHGRIPYPG 223 >2W1I-A nrPDB Length = 326 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 102/201 (50%), Gaps = 8/201 (3%) Query: 45 LQYIGEGAYGMVSSA-YDHVRKTRVAIKKISPFEHQT--YCQRTLREIQILLRFRHENVI 101 LQ +G+G +G V YD ++ + + +H T + + REI+IL +H+N++ Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIV 105 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY--QILRGLKYIHS 159 + + ++ ++ I++ L L L+ + DHI Y QI +G++Y+ + Sbjct: 106 KYKGVCYSAGRRNLK--LIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGT 163 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 +HRDL N+L+ +KI DFGL ++ + ++ + ++ APE + S Sbjct: 164 KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTES 223 Query: 220 KGYTKSIDIWSVGCILAEMLS 240 K ++ + D+WS G +L E+ + Sbjct: 224 K-FSVASDVWSFGVVLYELFT 243 >3KA0-A nrPDB Length = 320 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 78/299 (26%), Positives = 134/299 (44%), Gaps = 51/299 (17%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-ENVIGIR 104 Q +G G G V ++ + + A+K + C + RE+++ R +++ I Sbjct: 22 QVLGLGINGKVLQIFNKRTQEKFALKMLQD------CPKARREVELHWRASQCPHIVRIV 75 Query: 105 DILRASTLEAMRDVYIVQDLMET----DLYKLLKS---QQLSNDHICYFLYQILRGLKYI 157 D+ L A R ++ +ME +L+ ++ Q + + I ++Y+ Sbjct: 76 DVY--ENLYAGRKCLLI--VMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 131 Query: 158 HSANVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 HS N+ HRD+KP NLL + LK+ DFG A+ E LTE T +Y APE Sbjct: 132 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTEPCYTPYYVAPE 187 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 + L + Y KS D+WS+G I+ +L P F H G+ SP + Sbjct: 188 V-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH---------GLAISPG-------MK 230 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDR-MLTFNPNKRITVEEALAHPYLEQ 332 + R P+ W+++ S+ + +L R +L P +R+T+ E + HP++ Q Sbjct: 231 TRIRMGQYEFPNP---EWSEV-----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 281 >3IO7-A nrPDB Length = 313 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 102/201 (50%), Gaps = 8/201 (3%) Query: 45 LQYIGEGAYGMVSSA-YDHVRKTRVAIKKISPFEHQT--YCQRTLREIQILLRFRHENVI 101 LQ +G+G +G V YD ++ + + +H T + + REI+IL +H+N++ Sbjct: 33 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIV 92 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY--QILRGLKYIHS 159 + + ++ ++ I++ L L L+ + DHI Y QI +G++Y+ + Sbjct: 93 KYKGVCYSAGRRNLK--LIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGT 150 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 +HRDL N+L+ +KI DFGL ++ + ++ + ++ APE + S Sbjct: 151 KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTES 210 Query: 220 KGYTKSIDIWSVGCILAEMLS 240 K ++ + D+WS G +L E+ + Sbjct: 211 K-FSVASDVWSFGVVLYELFT 230 >2X7G-A nrPDB Length = 389 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 94/365 (25%), Positives = 147/365 (40%), Gaps = 84/365 (23%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN- 99 RY ++ +G G + V +D K VA+K + +H Y + L EI++L R + Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQH--YTETALDEIKLLKCVRESDP 89 Query: 100 -------VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS--QQLSNDHICYFLYQI 150 V+ + D + S + + + + L L ++KS Q L + + Q+ Sbjct: 90 SDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQV 149 Query: 151 LRGLKYIHS-ANVLHRDLKPSNLLINT--------------------------------T 177 L+GL Y+HS ++H D+KP N+L+ Sbjct: 150 LQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPA 209 Query: 178 CDL---------------KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 DL KI D G A H H TE + TR YR+ E+++ + GY Sbjct: 210 ADLLVNPLDPRNADKIRVKIADLGNACWV---HKH---FTEDIQTRQYRSIEVLIGA-GY 262 Query: 223 TKSIDIWSVGCILAEMLSNRPIF---PGKHYL---DQLNHILGILGS-PSQEDLNCIINM 275 + DIWS C+ E+ + +F G+ Y D + HI+ +LGS P L+ + Sbjct: 263 STPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSR 322 Query: 276 KARNYLQSLPSKTKVAWAKLF---------PKSDSKAL-DLLDRMLTFNPNKRITVEEAL 325 + N L TK+ LF P D+ D L ML P KR + E L Sbjct: 323 EFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECL 382 Query: 326 AHPYL 330 HP+L Sbjct: 383 RHPWL 387 >6C9D-A nrPDB Length = 459 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 102/211 (48%), Gaps = 12/211 (5%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENV 100 Y + IG+G + V A + VA+K I + + T Q+ RE++I+ H N+ Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 82 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ-QLSNDHICYFLYQILRGLKYIH 158 + + +++ E + +Y+V + +++ L + ++ QI+ ++Y H Sbjct: 83 VKLFEVI-----ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 137 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 ++HRDLK NLL++ ++KI DFG + E L E+ + Y APE+ Sbjct: 138 QKYIVHRDLKAENLLLDGDMNIKIADFGFSN----EFTVGNKLDEFCGSPPYAAPELFQG 193 Query: 219 SKGYTKSIDIWSVGCILAEMLSNRPIFPGKH 249 K +D+WS+G IL ++S F G++ Sbjct: 194 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQN 224 >5KZ7-A nrPDB Length = 346 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 54/211 (25%), Positives = 102/211 (48%), Gaps = 12/211 (5%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENV 100 Y L+ IG+G + V A + VA+K I + + + Q+ RE++I+ H N+ Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 94 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ-QLSNDHICYFLYQILRGLKYIH 158 + + +++ E + +Y+V + +++ L + ++ QI+ ++Y H Sbjct: 95 VKLFEVI-----ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 149 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 ++HRDLK NLL++ ++KI DFG + E L + + Y APE+ Sbjct: 150 QKFIVHRDLKAENLLLDADMNIKIADFGFSN----EFTFGNKLDTFCGSPPYAAPELFQG 205 Query: 219 SKGYTKSIDIWSVGCILAEMLSNRPIFPGKH 249 K +D+WS+G IL ++S F G++ Sbjct: 206 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQN 236 >2R2P-A nrPDB Length = 295 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 62/201 (30%), Positives = 98/201 (48%), Gaps = 16/201 (7%) Query: 48 IGEGAYGMVSSAYDHV---RKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 IG G +G V S + R+ VAIK + + + L E I+ +F H N+I + Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLE 89 Query: 105 DILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSAN 161 ++ S + V IV + ME D + Q + + L I G+KY+ Sbjct: 90 GVVTKS-----KPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMG 144 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLARIA--DPEHDHTGFLTEYVATRWYRAPEIMLNS 219 +HRDL N+LIN+ K+ DFGL+R+ DPE +T + + RW APE + Sbjct: 145 YVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGK-IPIRW-TAPEAIAFR 202 Query: 220 KGYTKSIDIWSVGCILAEMLS 240 K +T + D+WS G ++ E++S Sbjct: 203 K-FTSASDVWSYGIVMWEVVS 222 >4WUA-A nrPDB Length = 401 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 92/372 (24%), Positives = 146/372 (39%), Gaps = 96/372 (25%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH--- 97 RY ++ +G G + V ++D K VA+K + EH Y + L EI++L R+ Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEH--YTETALDEIRLLKSVRNSDP 99 Query: 98 -----ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS--QQLSNDHICYFLYQI 150 E V+ + D + S + + + L L ++KS Q L + + Q+ Sbjct: 100 NDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQV 159 Query: 151 LRGLKYIHS-ANVLHRDLKPSNLLINTT-------------------------------- 177 L+GL Y+H+ ++H D+KP N+L++ Sbjct: 160 LQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPA 219 Query: 178 -----------------CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 +KI D G A H H TE + TR YR+ E+++ S Sbjct: 220 TAGNFLVNPLEPKNAEKLKVKIADLGNACWV---HKH---FTEDIQTRQYRSLEVLIGS- 272 Query: 221 GYTKSIDIWSVGCILAEMLSNRPIF---PGKHYLDQLNHI-------------LGILGSP 264 GY DIWS C+ E+ + +F G+ Y +HI L + G Sbjct: 273 GYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKY 332 Query: 265 SQE------DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKR 318 S+E DL I +K + L K + W++ + + D L ML P KR Sbjct: 333 SKEFFTKKGDLKHITKLKPWGLFEVLVEKYE--WSQ---EEAAGFTDFLLPMLELIPEKR 387 Query: 319 ITVEEALAHPYL 330 T E L HP+L Sbjct: 388 ATAAECLRHPWL 399 >1BYG-A nrPDB Length = 278 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 97/200 (48%), Gaps = 20/200 (10%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 LQ IG+G +G V R +VA+K I ++ Q L E ++ + RH N++ + Sbjct: 26 LQTIGKGEFGDV--MLGDYRGNKVAVKCI---KNDATAQAFLAEASVMTQLRHSNLVQLL 80 Query: 105 DILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ---LSNDHICYFLYQILRGLKYIHSA 160 ++ +E +YIV + M + L L+S+ L D + F + ++Y+ Sbjct: 81 GVI----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 136 Query: 161 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 N +HRDL N+L++ K+ DFGL + A D T + +W APE + K Sbjct: 137 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-----TGKLPVKW-TAPEALREKK 190 Query: 221 GYTKSIDIWSVGCILAEMLS 240 TKS D+WS G +L E+ S Sbjct: 191 FSTKS-DVWSFGILLWEIYS 209 >1TKI-A nrPDB Length = 321 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 63/260 (24%), Positives = 125/260 (48%), Gaps = 42/260 (16%) Query: 87 REIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQ--QLSNDHI 143 +EI IL RH N++ + + + E+M ++ ++ + + D+++ + + +L+ I Sbjct: 50 KEISILNIARHRNILHLHE-----SFESMEELVMIFEFISGLDIFERINTSAFELNEREI 104 Query: 144 CYFLYQILRGLKYIHSANVLHRDLKPSNLLINT--TCDLKICDFGLARIADPEHDHTGFL 201 +++Q+ L+++HS N+ H D++P N++ T + +KI +FG AR P + F Sbjct: 105 VSYVHQVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDN---FR 161 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 261 + A +Y APE+ + T + D+WS+G ++ +LS F L Sbjct: 162 LLFTAPEYY-APEVHQHDVVSTAT-DMWSLGTLVYVLLSGINPF---------------L 204 Query: 262 GSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 321 +Q+ + I+N + ++ F + +A+D +DR+L R+T Sbjct: 205 AETNQQIIENIMNAEYTFDEEA------------FKEISIEAMDFVDRLLVKERKSRMTA 252 Query: 322 EEALAHPYLEQYYDPTDEPV 341 EAL HP+L+Q + V Sbjct: 253 SEALQHPWLKQKIERVSTKV 272 >4F9B-A nrPDB Length = 361 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 91/342 (26%), Positives = 146/342 (42%), Gaps = 71/342 (20%) Query: 48 IGEGAYGMVSSAYDHVR---KTRVAIKKISPFEHQTYCQRTLREIQIL-LRFRHENVIGI 103 IGEG + V A ++ + ++A+K + P H R E+Q L + +NV+G+ Sbjct: 29 IGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPI---RIAAELQCLTVAGGQDNVMGV 85 Query: 104 RDILRASTLEAMRDVYIVQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLKYIHSANV 162 + R + V I +E + + +L S LS + ++ + + LK IH + Sbjct: 86 KYCFRKND-----HVVIAMPYLEHESFLDILNS--LSFQEVREYMLNLFKALKRIHQFGI 138 Query: 163 LHRDLKPSNLLINTTC-DLKICDFGLARIADPEHDHTGFLTEYV---------------- 205 +HRD+KPSN L N + DFGLA+ HD L ++V Sbjct: 139 VHRDVKPSNFLYNRRLKKYALVDFGLAQ---GTHDTKIELLKFVQSEAQQERCSQNKCSI 195 Query: 206 ------------ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLD 252 T +RAPE++ T +ID+WS G I +LS R P + L Sbjct: 196 CLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLT 255 Query: 253 QLNHILGILGSPSQ--------EDLNCIINMKARNY------LQSLPSKTKVAWAKL--- 295 L I+ I GS + + C + A++ L+ + S T + + Sbjct: 256 ALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGH 315 Query: 296 ------FPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + + +A DLLD++L NP RIT EEAL HP+ + Sbjct: 316 ATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFK 357 >5N23-A nrPDB Length = 352 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 41/109 (37%), Positives = 63/109 (57%), Gaps = 6/109 (5%) Query: 137 QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 + S H ++ QI+ +Y+HS ++++RDLKP NLLI+ +K+ DFG A+ Sbjct: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTP 197 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 T T Y APEI+L SKGY K++D W++G ++ EM + P F Sbjct: 198 WT-----LCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPF 240 >5X3F-B nrPDB Length = 393 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 102/213 (47%), Gaps = 24/213 (11%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIK--------KISPFEHQTYCQRTLREIQIL 92 ++ +++ +G G++G V A+K K+ EH TL E +IL Sbjct: 85 QFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEH------TLNEKRIL 138 Query: 93 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILR 152 ++ + + ++ M Y+ M + L ++ + S H ++ QI+ Sbjct: 139 QAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRI---GRFSEPHARFYAAQIVL 195 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 +Y+HS ++++RDLKP NLLI+ +++ DFG A+ G T Y A Sbjct: 196 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV------KGRTWTLCGTPEYLA 249 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 PEI+L SKGY K++D W++G ++ EM + P F Sbjct: 250 PEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPF 281 >2HW6-A nrPDB Length = 307 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 71/306 (23%), Positives = 128/306 (41%), Gaps = 44/306 (14%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR-HENVIGIR 104 + +GEGAY V A A+K I + R RE++ L + + ++N++ + Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSR-SRVFREVETLYQCQGNKNILELI 77 Query: 105 DILRASTLEAMRDVYIVQDLME--TDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANV 162 + T Y+V + ++ + L + K + + + + L ++H+ + Sbjct: 78 EFFEDDT-----RFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGI 132 Query: 163 LHRDLKPSNLLINT---TCDLKICDFGLAR----------IADPEHDHTGFLTEYVATRW 209 HRDLKP N+L + +KICDF L I PE LT + Sbjct: 133 AHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPE------LTTPCGSAE 186 Query: 210 YRAPEIML----NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 Y APE++ + Y K D+WS+G +L MLS P F +G G+ Sbjct: 187 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPF------------VGHCGADC 234 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 D + + +S+ K + S+A DL+ ++L + +R++ + L Sbjct: 235 GWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVL 294 Query: 326 AHPYLE 331 HP+++ Sbjct: 295 QHPWVQ 300 >1K9A-A nrPDB Length = 450 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 97/200 (48%), Gaps = 20/200 (10%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 LQ IG+G +G V R +VA+K I ++ Q L E ++ + RH N++ + Sbjct: 198 LQTIGKGEFGDV--MLGDYRGNKVAVKCI---KNDATAQAFLAEASVMTQLRHSNLVQLL 252 Query: 105 DILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ---LSNDHICYFLYQILRGLKYIHSA 160 ++ +E +YIV + M + L L+S+ L D + F + ++Y+ Sbjct: 253 GVI----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 Query: 161 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 N +HRDL N+L++ K+ DFGL + A D T + +W APE + K Sbjct: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-----TGKLPVKW-TAPEALREKK 362 Query: 221 GYTKSIDIWSVGCILAEMLS 240 TKS D+WS G +L E+ S Sbjct: 363 FSTKS-DVWSFGILLWEIYS 381 >6BDL-A nrPDB Length = 347 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 101/207 (48%), Gaps = 23/207 (11%) Query: 67 RVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLE-------AMRDVY 119 RV + ++ E +T+ + L++ I+ + E++ + I++ + + +D Sbjct: 49 RVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSK 108 Query: 120 IVQDLMET----DLYKLLKSQQLSNDHICYFLYQ-ILRGLKYIHSANVLHRDLKPSNLLI 174 + LME +L+ +L+ + D F ++ Y+HS +++RDLKP NL++ Sbjct: 109 YLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLIL 168 Query: 175 NTTCDLKICDFGLARIADPEHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSV 231 + K+ DFG A+ GF + + T Y APEI+LN KG+ S D WS+ Sbjct: 169 DHRGYAKLVDFGFAK-------KIGFGKKTWTFCGTPEYVAPEIILN-KGHDISADYWSL 220 Query: 232 GCILAEMLSNRPIFPGKHYLDQLNHIL 258 G ++ E+L+ P F G + N IL Sbjct: 221 GILMYELLTGSPPFSGPDPMKTYNIIL 247 >6CKI-A nrPDB Length = 316 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 75/305 (24%), Positives = 126/305 (41%), Gaps = 38/305 (12%) Query: 44 QLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR-HENVIG 102 Q +GEGA+ V + + + A+K I R RE+++L + + H NV+ Sbjct: 17 QEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIR-SRVFREVEMLYQCQGHRNVLE 75 Query: 103 IRDILRAS-----TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYI 157 + + E MR I+ + + + L++ + D + L ++ Sbjct: 76 LIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQD--------VASALDFL 127 Query: 158 HSANVLHRDLKPSNLLI---NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW----Y 210 H+ + HRDLKP N+L N +KICDFGL D + T + T Y Sbjct: 128 HNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEY 187 Query: 211 RAPEIM----LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 APE++ + Y K D+WS+G IL +LS P F G+ D G Sbjct: 188 MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD--------CGWDRG 239 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 E NM + + WA + A DL+ ++L + +R++ + L Sbjct: 240 EACPACQNMLFESIQEGKYEFPDKDWAHI----SCAAKDLISKLLVRDAKQRLSAAQVLQ 295 Query: 327 HPYLE 331 HP+++ Sbjct: 296 HPWVQ 300 >4U41-A nrPDB Length = 332 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 95/209 (45%), Gaps = 15/209 (7%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGI- 103 ++ +G G YG V HV+ ++A K+ + L EI +L ++ H I Sbjct: 29 VEVVGNGTYGQVYKGR-HVKTGQLAAIKVMDVTEDEEEEIKL-EINMLKKYSHHRNIATY 86 Query: 104 -RDILRASTLEAMRDVYIVQDLME----TDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 ++ S +++V + TDL K K L D I Y +ILRGL ++H Sbjct: 87 YGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLH 146 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 +V+HRD+K N+L+ ++K+ DFG++ D G ++ T ++ APE++ Sbjct: 147 IHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT---VGRRNTFIGTPYWMAPEVIAC 203 Query: 219 SKG----YTKSIDIWSVGCILAEMLSNRP 243 + Y D+WS G EM P Sbjct: 204 DENPDATYDYRSDLWSCGITAIEMAEGAP 232 >6DBN-A nrPDB Length = 316 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 100/207 (48%), Gaps = 17/207 (8%) Query: 44 QLQYIGEGAYGMVS-SAYD---HVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 +++ +GEG +G V YD +VA+K + P + +EI+IL HEN Sbjct: 39 RIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHEN 98 Query: 100 VIGIRDILRASTLEAMRDVY------IVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 ++ + I ++ + +++ + + K+ QQL + QI +G Sbjct: 99 IVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLK------YAVQICKG 152 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 + Y+ S +HRDL N+L+ + +KI DFGL + + + ++ + + ++ AP Sbjct: 153 MDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAP 212 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLS 240 E ++ SK Y S D+WS G L E+L+ Sbjct: 213 ECLMQSKFYIAS-DVWSFGVTLHELLT 238 >4P5Q-A nrPDB Length = 361 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 99/203 (48%), Gaps = 16/203 (7%) Query: 46 QYIGEGAYGMVSSAYDHV---RKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 + +G G +G V S + ++ VAIK + + + L E I+ +F H N+I Sbjct: 39 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIR 98 Query: 103 IRDILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159 + ++ S + V IV + ME D + Q + + L I G+KY+ Sbjct: 99 LEGVVTKS-----KPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSD 153 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIA--DPEHDHTGFLTEYVATRWYRAPEIML 217 +HRDL N+LIN+ K+ DFGL+R+ DPE +T + + RW +PE + Sbjct: 154 MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGK-IPIRW-TSPEAIA 211 Query: 218 NSKGYTKSIDIWSVGCILAEMLS 240 K +T + D+WS G +L E++S Sbjct: 212 YRK-FTSASDVWSYGIVLWEVMS 233 >2VWV-A nrPDB Length = 302 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 62/222 (27%), Positives = 101/222 (45%), Gaps = 24/222 (10%) Query: 46 QYIGEGAYGMVSSAYDHV---RKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 + IG G +G V +++ VAIK + + + L E I+ +F H N+I Sbjct: 22 EVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIR 81 Query: 103 IRDILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159 + ++ S V I+ + ME D + L Q + + L I G++Y+ Sbjct: 82 LEGVVTNSM-----PVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAE 136 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARI-----ADPEHDHTGFLTEYVATRWYRAPE 214 + +HRDL N+L+N+ K+ DFGL+R +DP T L + RW APE Sbjct: 137 MSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDP--TETSSLGGKIPIRWT-APE 193 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 + K +T + D WS G ++ E++S F + Y D N Sbjct: 194 AIAFRK-FTSASDAWSYGIVMWEVMS----FGERPYWDMSNQ 230 >4CFF-A nrPDB Length = 571 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 98/217 (45%), Gaps = 15/217 (6%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 +G G +G V + +VA+K ++ + REIQ L FRH ++I + Sbjct: 41 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 100 Query: 106 ILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 ++ T D ++V + + +L+ + K ++ QIL + Y H V+ Sbjct: 101 VISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 155 Query: 164 HRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 HRDLKP N+L++ + KI DFGL+ ++D E FL + Y APE++ Sbjct: 156 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGE-----FLRTSCGSPNYAAPEVISGRLYA 210 Query: 223 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 259 +DIWS G IL +L F +H I G Sbjct: 211 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRG 247 >4WB7-A nrPDB Length = 405 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 40/109 (36%), Positives = 63/109 (57%), Gaps = 7/109 (6%) Query: 137 QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 + S H ++ QI+ +Y+HS ++++RDLKP NLLI+ +++ DFG A+ Sbjct: 192 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV----- 246 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 G T Y APEI+L SKGY K++D W++G ++ EM + P F Sbjct: 247 -KGRTWTLCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPF 293 >2YZA-A nrPDB Length = 276 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 97/207 (46%), Gaps = 15/207 (7%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 +G G +G V + +VA+K ++ + REIQ L FRH ++I + Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 78 Query: 106 ILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 ++ T D ++V + + +L+ + K ++ QIL + Y H V+ Sbjct: 79 VISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 133 Query: 164 HRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 HRDLKP N+L++ + KI DFGL+ ++D E FL + + Y APE++ Sbjct: 134 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGE-----FLRDSCGSPNYAAPEVISGRLYA 188 Query: 223 TKSIDIWSVGCILAEMLSNRPIFPGKH 249 +DIWS G IL +L F +H Sbjct: 189 GPEVDIWSCGVILYALLCGTLPFDDEH 215 >4GS6-A nrPDB Length = 315 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 79/306 (25%), Positives = 138/306 (45%), Gaps = 57/306 (18%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 + +G GA+G+V A R VAIK+I E ++ + + E++ L R H N++ + Sbjct: 15 EVVGRGAFGVVCKA--KWRAKDVAIKQI---ESESERKAFIVELRQLSRVNHPNIVKLYG 69 Query: 106 ILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ----LSNDHICYFLYQILRGLKYIHSA 160 + V +V + E LY +L + + H + Q +G+ Y+HS Sbjct: 70 -------ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 122 Query: 161 N---VLHRDLKPSN-LLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 ++HRDLKP N LL+ LKICDFG A D +T + + APE+ Sbjct: 123 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA------CDIQTHMTNNKGSAAWMAPEVF 176 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 S Y++ D++S G IL E+++ R F D+ +G P+ + + N Sbjct: 177 EGSN-YSEKCDVFSWGIILWEVITRRKPF------DE-------IGGPAFRIMWAVHNGT 222 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA-HPYLEQYYD 335 +++LP + L+ R + +P++R ++EE + +L +Y+ Sbjct: 223 RPPLIKNLPKPIE---------------SLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFP 267 Query: 336 PTDEPV 341 DEP+ Sbjct: 268 GADEPL 273 >4PDO-A nrPDB Length = 299 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 109/226 (48%), Gaps = 27/226 (11%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTR-------VAIKKISPFEHQTYCQRTLREIQILLRF 95 T+ + IG G +G V Y + KT VAIK + + L E I+ +F Sbjct: 37 TRQKVIGAGEFGEV---YKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQF 93 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILR 152 H N+I + ++ + + I+ + ME D + K + S + L I Sbjct: 94 SHHNIIRLEGVI-----SKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAA 148 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA--DPEHDHTGFLTEYVATRWY 210 G+KY+ + N +HRDL N+L+N+ K+ DFGL+R+ DPE +T + + RW Sbjct: 149 GMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGK-IPIRW- 206 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 APE ++ + +T + D+WS G ++ E+++ + + Y + NH Sbjct: 207 TAPE-AISYRKFTSASDVWSFGIVMWEVMT----YGERPYWELSNH 247 >5EZV-A nrPDB Length = 560 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 96/207 (46%), Gaps = 15/207 (7%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 +G G +G V + +VA+K ++ + REIQ L FRH ++I + Sbjct: 36 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 95 Query: 106 ILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 ++ T D ++V + + +L+ + K ++ QIL + Y H V+ Sbjct: 96 VISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 150 Query: 164 HRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 HRDLKP N+L++ + KI DFGL+ ++D E FL + Y APE++ Sbjct: 151 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGE-----FLRTSCGSPNYAAPEVISGRLYA 205 Query: 223 TKSIDIWSVGCILAEMLSNRPIFPGKH 249 +DIWS G IL +L F +H Sbjct: 206 GPEVDIWSCGVILYALLCGTLPFDDEH 232 >4UYA-A nrPDB Length = 340 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 65/229 (28%), Positives = 106/229 (46%), Gaps = 23/229 (10%) Query: 32 KGQPFDVGPRYTQL-QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-EI 89 +G P V +L + IG G +G V A ++ V + P + ++R E Sbjct: 17 QGSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREA 76 Query: 90 QILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQ 149 ++ RH N+I +R + L+ +++ L + L +++ + + Q Sbjct: 77 RLFAMLRHPNIIELRGV----CLQQPHLCLVLEFARGGALNRALAGRRIPPHVLVNWAVQ 132 Query: 150 ILRGLKYIHSAN---VLHRDLKPSNLLI------NTTCD--LKICDFGLARIADPEHDHT 198 I RG+ Y+H +LHRDLK SN+L+ + C+ LKI DFGLAR E T Sbjct: 133 IARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR----EWHRT 188 Query: 199 GFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 247 + A W APE+ + S ++K DIWS G +L E+L+ + G Sbjct: 189 TKMATAGAYAWM-APEV-IKSSLFSKGSDIWSYGVLLWELLTGEVPYRG 235 >2OZA-A nrPDB Length = 356 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 77/299 (25%), Positives = 133/299 (44%), Gaps = 51/299 (17%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-ENVIGIR 104 Q +G G G V ++ + + A+K + C + RE+++ R +++ I Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQD------CPKARREVELHWRASQCPHIVRIV 77 Query: 105 DILRASTLEAMRDVYIVQDLMET----DLYKLLKS---QQLSNDHICYFLYQILRGLKYI 157 D+ L A R ++ +ME +L+ ++ Q + + I ++Y+ Sbjct: 78 DVY--ENLYAGRKCLLI--VMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 133 Query: 158 HSANVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 HS N+ HRD+KP NLL + LK+ DFG A+ E LT T +Y APE Sbjct: 134 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTTPCYTPYYVAPE 189 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 + L + Y KS D+WS+G I+ +L P F H G+ SP + Sbjct: 190 V-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH---------GLAISPG-------MK 232 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDR-MLTFNPNKRITVEEALAHPYLEQ 332 + R P+ W+++ S+ + +L R +L P +R+T+ E + HP++ Q Sbjct: 233 TRIRMGQYEFPNP---EWSEV-----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 283 >1NY3-A nrPDB Length = 400 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 77/299 (25%), Positives = 133/299 (44%), Gaps = 51/299 (17%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-ENVIGIR 104 Q +G G G V ++ + + A+K + C + RE+++ R +++ I Sbjct: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQD------CPKARREVELHWRASQCPHIVRIV 121 Query: 105 DILRASTLEAMRDVYIVQDLMET----DLYKLLKS---QQLSNDHICYFLYQILRGLKYI 157 D+ L A R ++ +ME +L+ ++ Q + + I ++Y+ Sbjct: 122 DVY--ENLYAGRKCLLI--VMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 Query: 158 HSANVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 HS N+ HRD+KP NLL + LK+ DFG A+ E LT T +Y APE Sbjct: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTTPCYTPYYVAPE 233 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 + L + Y KS D+WS+G I+ +L P F H G+ SP + Sbjct: 234 V-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH---------GLAISPG-------MK 276 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDR-MLTFNPNKRITVEEALAHPYLEQ 332 + R P+ W+++ S+ + +L R +L P +R+T+ E + HP++ Q Sbjct: 277 TRIRMGQYEFPNP---EWSEV-----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 >2HAK-A nrPDB Length = 328 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 54/211 (25%), Positives = 101/211 (47%), Gaps = 12/211 (5%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENV 100 Y + IG+G + V A + VA+K I + + T Q+ RE++I+ H N+ Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 76 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ-QLSNDHICYFLYQILRGLKYIH 158 + + +++ E + +Y+V + +++ L + ++ QI+ ++Y H Sbjct: 77 VKLFEVI-----ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 131 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 ++HRDLK NLL++ ++KI DFG + E L + + Y APE+ Sbjct: 132 QKYIVHRDLKAENLLLDGDMNIKIADFGFSN----EFTVGNKLDTFCGSPPYAAPELFQG 187 Query: 219 SKGYTKSIDIWSVGCILAEMLSNRPIFPGKH 249 K +D+WS+G IL ++S F G++ Sbjct: 188 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQN 218 >3TAC-A nrPDB Length = 361 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 77/306 (25%), Positives = 140/306 (45%), Gaps = 54/306 (17%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY----CQRTLREIQILLRFRH 97 Y + IG+G + +V + + A+K + + + + RE I +H Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLME-TDL-YKLLKSQQ----LSNDHICYFLYQIL 151 +++ ++L + + M +Y+V + M+ DL ++++K S +++ QIL Sbjct: 88 PHIV---ELLETYSSDGM--LYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQIL 142 Query: 152 RGLKYIHSANVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLT-EYVAT 207 L+Y H N++HRD+KP +L+ + + +K+ FG+A + +G + V T Sbjct: 143 EALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVA----IQLGESGLVAGGRVGT 198 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN-RPIFPGKHYLDQLNHILGILGSPSQ 266 + APE+ + + Y K +D+W G IL +LS P + K L + GI+ + Sbjct: 199 PHFMAPEV-VKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFE-----GIIKGKYK 252 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 M R W+ + A DL+ RML +P +RITV EAL Sbjct: 253 --------MNPRQ------------WSHI----SESAKDLVRRMLMLDPAERITVYEALN 288 Query: 327 HPYLEQ 332 HP+L++ Sbjct: 289 HPWLKE 294 >1AD5-A nrPDB Length = 438 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 98/205 (47%), Gaps = 27/205 (13%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G G +G V A + + T+VA+K + P + L E ++ +H+ ++ + ++ Sbjct: 190 LGAGQFGEVWMA-TYNKHTKVAVKTMKP--GSMSVEAFLAEANVMKTLQHDKLVKLHAVV 246 Query: 108 RASTLEAMRDVYIVQDLM-ETDLYKLLKSQQLSND---HICYFLYQILRGLKYIHSANVL 163 +YI+ + M + L LKS + S + F QI G+ +I N + Sbjct: 247 ------TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYI 300 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 223 HRDL+ +N+L++ + KI DFGLAR+ +W APE +N +T Sbjct: 301 HRDLRAANILVSASLVCKIADFGLARVGAK-----------FPIKW-TAPE-AINFGSFT 347 Query: 224 KSIDIWSVGCILAEMLS-NRPIFPG 247 D+WS G +L E+++ R +PG Sbjct: 348 IKSDVWSFGILLMEIVTYGRIPYPG 372 >4FR4-A nrPDB Length = 384 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 111/227 (48%), Gaps = 21/227 (9%) Query: 22 PGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQ 79 P V E E V F++ L+ IG+G++G V + K A+K ++ + + Sbjct: 3 PPVFDENEDVNFDHFEI------LRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVER 56 Query: 80 TYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDL-YKLLKSQQ 137 + +E+QI+ H ++ + + + D+++V DL+ DL Y L ++ Sbjct: 57 NEVRNVFKELQIMQGLEHPFLVNL-----WYSFQDEEDMFMVVDLLLGGDLRYHLQQNVH 111 Query: 138 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDH 197 + + F+ +++ L Y+ + ++HRD+KP N+L++ + I DF +A + E Sbjct: 112 FKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQ- 170 Query: 198 TGFLTEYVATRWYRAPEIMLNSK--GYTKSIDIWSVGCILAEMLSNR 242 +T T+ Y APE+ + K GY+ ++D WS+G E+L R Sbjct: 171 ---ITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGR 214 >5WNO-A nrPDB Length = 330 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 54/198 (27%), Positives = 93/198 (46%), Gaps = 11/198 (5%) Query: 48 IGEGAYGMVSSAYDHVRKTR-----VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 +G GA+G V + + ++ + VAIK + QT L E + R RH+N++ Sbjct: 30 LGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQT--DEMLEEATNMFRLRHDNLLK 87 Query: 103 IRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANV 162 I + ++ V I + L + L + L + YQI G++Y+ V Sbjct: 88 IIGFCMHD--DGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRV 145 Query: 163 LHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 +HRDL N+L+ ++I DFGL++I + D + VA +W A EI + Y Sbjct: 146 VHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWL-AIEI-FSKHCY 203 Query: 223 TKSIDIWSVGCILAEMLS 240 T + D+W+ G E+++ Sbjct: 204 THASDVWAFGVTCWEIIT 221 >2UV2-A nrPDB Length = 325 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 75/315 (23%), Positives = 129/315 (40%), Gaps = 45/315 (14%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G+GA+G V A + + +A K+ + + + + EI IL H N++ + D Sbjct: 45 LGDGAFGKVYKAQNK-ETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAF 103 Query: 108 RASTLEAMRDVYIVQDLME---TDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLH 164 +++I+ + D L + L+ I Q L L Y+H ++H Sbjct: 104 YYEN-----NLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIH 158 Query: 165 RDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML----NSK 220 RDLK N+L D+K+ DFG ++ ++ T ++ APE+++ + Sbjct: 159 RDLKAGNILFTLDGDIKLADFG---VSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDR 215 Query: 221 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNY 280 Y D+WS+G L EM I P H L+ + +L I K+ Sbjct: 216 PYDYKADVWSLGITLIEMAE---IEPPHHELNPMRVLLKI--------------AKSEPP 258 Query: 281 LQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE-QYYDPTDE 339 + PS+ W+ F D L + L N + R T + L HP++ P E Sbjct: 259 TLAQPSR----WSSNFK-------DFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRE 307 Query: 340 PVAEEPFTFAMELDD 354 +AE E++D Sbjct: 308 LIAEAKAEVTEEVED 322 >3DTC-A nrPDB Length = 271 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 61/214 (28%), Positives = 101/214 (47%), Gaps = 22/214 (10%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-EIQILLRFRHENVIGIR 104 + IG G +G V A+ + V + P E + +R E ++ +H N+I +R Sbjct: 13 EIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 72 Query: 105 DILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS---AN 161 + L+ +++ L ++L +++ D + + QI RG+ Y+H Sbjct: 73 GV----CLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVP 128 Query: 162 VLHRDLKPSNLLINTTCD--------LKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 ++HRDLK SN+LI + LKI DFGLAR E T ++ A W AP Sbjct: 129 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR----EWHRTTKMSAAGAYAWM-AP 183 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 247 E++ S ++K D+WS G +L E+L+ F G Sbjct: 184 EVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRG 216 >4TNB-A nrPDB Length = 590 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 61/218 (27%), Positives = 105/218 (48%), Gaps = 26/218 (11%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKT-------RVAIKKISPFEHQTYCQRTLREIQILLR 94 + Q + +G+G +G V + VR T R+ K+I + ++ L E QIL + Sbjct: 186 FRQYRVLGKGGFGEVCAC--QVRATGKMYACKRLEKKRIKKRKGESM---ALNEKQILEK 240 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKL----LKSQQLSNDHICYFLYQI 150 + V+ + A E + +V +M K + + + ++ +I Sbjct: 241 VNSQFVVNL-----AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY 210 L GL+ +H N ++RDLKP N+L++ ++I D GLA + PE D + V T Y Sbjct: 296 LCGLEDLHHENTVYRDLKPENILLDDYGHIRISDLGLA-VKIPEGD---LIRGRVGTVGY 351 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 248 APE+ LN++ Y S D W +GC++ EM+ + F G+ Sbjct: 352 MAPEV-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 >3DKO-A nrPDB Length = 318 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 59/201 (29%), Positives = 96/201 (47%), Gaps = 16/201 (7%) Query: 48 IGEGAYGMVSSAYDHV---RKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 IG G +G V S + R VAIK + + + L E I+ +F H NV+ + Sbjct: 51 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLE 110 Query: 105 DILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSAN 161 ++ + V IV + ME D + Q + + L I G++Y+ Sbjct: 111 GVVTRG-----KPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMG 165 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLARIA--DPEHDHTGFLTEYVATRWYRAPEIMLNS 219 +HRDL N+L+N+ K+ DFGL+R+ DPE +T + + RW APE + Sbjct: 166 YVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGK-IPVRW-TAPEAIQYR 223 Query: 220 KGYTKSIDIWSVGCILAEMLS 240 K +T + D+WS G ++ E++S Sbjct: 224 K-FTSASDVWSYGIVMWEVMS 243 >3CJF-A nrPDB Length = 309 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 105/213 (49%), Gaps = 26/213 (12%) Query: 48 IGEGAYGMVSSA----YDHVRKTR-VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 +G GA+G V A D R VA+K + + + + E++IL+ H + Sbjct: 35 LGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHH--LN 92 Query: 103 IRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-------------LSNDHICYFLYQ 149 + ++L A T + IV+ +L L+S++ L+ +H+ + +Q Sbjct: 93 VVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQ 152 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR--IADPEHDHTGFLTEYVAT 207 + +G++++ S +HRDL N+L++ +KICDFGLAR DP++ G + Sbjct: 153 VAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKG--DARLPL 210 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 +W APE + + + YT D+WS G +L E+ S Sbjct: 211 KWM-APETIFD-RVYTIQSDVWSFGVLLWEIFS 241 >3ZUT-A nrPDB Length = 362 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 58/202 (28%), Positives = 95/202 (47%), Gaps = 13/202 (6%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 100 RY ++ IG G +G+ D VA+K I E + REI RH N+ Sbjct: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID--ENVKREIINHRSLRHPNI 77 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLKYIHS 159 + ++++ T A+ +++ +L+ ++ + + S D +F Q++ G+ Y H+ Sbjct: 78 VRFKEVILTPTHLAI----VMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 Query: 160 ANVLHRDLKPSNLLINTTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 V HRDLK N L++ + LKIC FG ++ + H V T Y APE++L Sbjct: 134 MQVCHRDLKLENTLLDGSPAPRLKICAFGYSK-SSVLHSQP---KSTVGTPAYIAPEVLL 189 Query: 218 NSKGYTKSIDIWSVGCILAEML 239 + K D+WS G L ML Sbjct: 190 KKEYDGKVADVWSCGVTLYVML 211 >3UDB-A nrPDB Length = 317 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 95/202 (47%), Gaps = 13/202 (6%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 100 RY ++ IG G +G+ D VA+K I E + REI RH N+ Sbjct: 20 RYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGE--KIDENVKREIINHRSLRHPNI 77 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLKYIHS 159 + ++++ T A+ +++ +L+ ++ + + S D +F Q++ G+ Y H+ Sbjct: 78 VRFKEVILTPTHLAI----VMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHA 133 Query: 160 ANVLHRDLKPSNLLINTTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 V HRDLK N L++ + LKI DFG ++ A H V T Y APE++L Sbjct: 134 MQVAHRDLKLENTLLDGSPAPRLKIADFGYSK-ASVLHSQP---KSAVGTPAYIAPEVLL 189 Query: 218 NSKGYTKSIDIWSVGCILAEML 239 + K D+WS G L ML Sbjct: 190 KKEYDGKVADVWSCGVTLYVML 211 >3G0E-A nrPDB Length = 336 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 101/220 (45%), Gaps = 35/220 (15%) Query: 48 IGEGAYGMV--SSAYDHVRK---TRVAIKKISPFEHQTYCQRTLREIQILLRF-RHENVI 101 +G GA+G V ++AY ++ VA+K + P H T + + E+++L H N++ Sbjct: 54 LGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIV 113 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICY---------------- 145 ++L A T+ V I + DL L+ ++ + IC Sbjct: 114 ---NLLGACTIGGPTLV-ITEYCCYGDLLNFLRRKR--DSFICSKTSPAIMEDDELALDL 167 Query: 146 -----FLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGF 200 F YQ+ +G+ ++ S N +HRDL N+L+ KICDFGLAR + ++ Sbjct: 168 EDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVK 227 Query: 201 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + +W APE + N YT D+WS G L E+ S Sbjct: 228 GNARLPVKW-MAPESIFNCV-YTFESDVWSYGIFLWELFS 265 >2A1A-B nrPDB Length = 284 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 67/266 (25%), Positives = 122/266 (45%), Gaps = 38/266 (14%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 G + +++ IG G +G V A + IK++ + ++ RE++ L + H Sbjct: 10 GMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRV-----KYNNEKAEREVKALAKLDHV 64 Query: 99 NVI---GIRDIL--------RASTLEAMRDVYIVQDLMETDLYKLL----KSQQLSNDHI 143 N++ G D + S+ + ++I + + + + ++L Sbjct: 65 NIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLA 124 Query: 144 CYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE 203 QI +G+ YIHS +++RDLKPSN+ + T +KI DFGL + ++D G T Sbjct: 125 LELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGL--VTSLKND--GKRTR 180 Query: 204 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML--SNRPIFPGKHYLDQLNHILGIL 261 T Y +PE ++S+ Y K +D++++G ILAE+L + K + D + I Sbjct: 181 SKGTLRYMSPE-QISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGI---- 235 Query: 262 GSPSQEDLNCIINMKARNYLQSLPSK 287 ++ I + K + LQ L SK Sbjct: 236 -------ISDIFDKKEKTLLQKLLSK 254 >6CTH-A nrPDB Length = 309 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 101/209 (48%), Gaps = 11/209 (5%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 V + +GEG +G V + T +A+KK+S Q + E++I+ R RH Sbjct: 13 VTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQG-IKEYASEVKIISRLRH 71 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQIL-RGLKY 156 +N++ + + ++ +++ ++K + L + Y + + L L Y Sbjct: 72 KNLVKLIGWCHERGELMLVYEFMANGSLDSHIFK---GKSLLTWEVRYRIVKDLASALLY 128 Query: 157 IHSAN---VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 +H VLHRD+K SN++++++ + K+ DFGLAR+ D H T T Y AP Sbjct: 129 LHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVD--HAKGLKKTLLAGTVGYMAP 186 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNR 242 E + + K +K D++S G + E+ S R Sbjct: 187 ECLSSGKA-SKESDVYSFGVVALEIASGR 214 >2Y6O-A nrPDB Length = 291 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 103/219 (47%), Gaps = 20/219 (9%) Query: 46 QYIGEGAYGMVSSAYDHV---RKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 + IG G +G V S V R+ VAIK + + L E I+ +F H N+I Sbjct: 20 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIH 79 Query: 103 IRDILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159 + ++ + V I+ + ME D + + + + L I G+KY+ Sbjct: 80 LEGVVTKC-----KPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSD 134 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIA--DPEHDHTGFLTEYVATRWYRAPEIML 217 + +HRDL N+L+N+ K+ DFG++R+ DPE +T + + RW APE + Sbjct: 135 MSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGK-IPIRW-TAPEAIA 192 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 K +T + D+WS G ++ E++S + + Y D N Sbjct: 193 YRK-FTSASDVWSYGIVMWEVMS----YGERPYWDMSNQ 226 >4UY9-A nrPDB Length = 323 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 59/214 (27%), Positives = 98/214 (45%), Gaps = 22/214 (10%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-EIQILLRFRHENVIGIR 104 + IG G +G V A+ + V + P E + +R E ++ +H N+I +R Sbjct: 15 EIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 74 Query: 105 DILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS---AN 161 + L+ +++ L ++L +++ D + + QI RG+ Y+H Sbjct: 75 GV----CLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVP 130 Query: 162 VLHRDLKPSNLLINTTCD--------LKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 ++HRDLK SN+LI + LKI DFGLAR H T + AP Sbjct: 131 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR-----EWHRTTKMSAAGTYAWMAP 185 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 247 E++ S ++K D+WS G +L E+L+ F G Sbjct: 186 EVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRG 218 >6J5U-C nrPDB Length = 426 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 57/212 (26%), Positives = 102/212 (48%), Gaps = 15/212 (7%) Query: 42 YTQLQYIGEGAYGMVSSAY-DHVRKTR--------VAIKKISPFEHQTYCQRTLREIQIL 92 + Q +GEG +G V + D T VA+K++ P Q + + L E+ L Sbjct: 86 FRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGH-KEWLTEVNYL 144 Query: 93 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILR 152 + H N++ + + ++ + +E L++ +Q L+ + Sbjct: 145 GQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRR-GAQPLTWAIRMKVAVGAAK 203 Query: 153 GLKYIHSAN--VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY 210 GL ++H A V++RD K +N+L++ + K+ DFGLA+ A P D+T T+ + T Y Sbjct: 204 GLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAK-AGPTGDNTHVSTKVIGTHGY 262 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 242 APE + + KS D++S G +L E++S R Sbjct: 263 AAPEYVATGRLTAKS-DVYSFGVVLLELISGR 293 >1S9I-A nrPDB Length = 354 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 107/211 (50%), Gaps = 19/211 (9%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ-RTLREIQILLRFRHENV 100 + ++ +G G G+V+ H + +K+ E + + + +RE+Q+L + Sbjct: 18 FERISELGAGNGGVVTKV-QHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 76 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLK-SQQLSNDHICYFLYQILRGLKYIH 158 +G + ++ I + M+ L ++LK ++++ + + +LRGL Y+ Sbjct: 77 VGFYGAFYSDG-----EISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLR 131 Query: 159 SAN-VLHRDLKPSNLLINTTCDLKICDFGLA-RIADPEHDHTGFLTEYVATRWYRAPEIM 216 + ++HRD+KPSN+L+N+ ++K+CDFG++ ++ D +V TR Y APE Sbjct: 132 EKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID------SMANSFVGTRSYMAPE-R 184 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNR-PIFP 246 L Y+ DIWS+G L E+ R PI P Sbjct: 185 LQGTHYSVQSDIWSMGLSLVELAVGRYPIPP 215 >5DYK-A nrPDB Length = 853 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 79/321 (24%), Positives = 139/321 (43%), Gaps = 55/321 (17%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 IG G +G V + K R A+K +S Q+ +++ + +++ IR + Sbjct: 547 IGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPFIIRLV- 605 Query: 108 RASTLEAMRDVYIVQDLMET-DLYKLL-KSQQLSNDHICYFLYQILRGLKYIHSANVLHR 165 T + + Y + +L+ +LY + K LS ++L I+ ++Y+H N+++R Sbjct: 606 --RTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHERNIVYR 663 Query: 166 DLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 225 DLKP N+L++ +K+ DFG A+ G V T Y APE++L KGY + Sbjct: 664 DLKPENILLDKQGYVKLIDFGCAKKVQ------GRAYTLVGTPHYMAPEVIL-GKGYGCT 716 Query: 226 IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLP 285 +DIW++G L E + P+ G DQL IL Sbjct: 717 VDIWALGICLYEFICG-PLPFGNDEEDQLEIFRDILTGQLT------------------- 756 Query: 286 SKTKVAWAKLFPK--SDSKALDLLDRMLTFNPNKRITV-----EEALAHPYLEQY-YDP- 336 FP +D+ +++L+ R+L P RI ++ HP+ + +D Sbjct: 757 ----------FPDYVTDTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKL 806 Query: 337 ----TDEPVAEEPFTFAMELD 353 D P+ + T+A ++D Sbjct: 807 AGRLLDPPLVSKSETYAEDID 827 >6DBM-A nrPDB Length = 318 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 100/214 (46%), Gaps = 8/214 (3%) Query: 33 GQPFDVGPRY-TQLQYIGEGAYGMVS-SAYDHVRKTR---VAIKKISPFEHQTYCQRTLR 87 G P RY +++ +GEG +G VS YD VA+K + + + Sbjct: 23 GDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQ 82 Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFL 147 EI IL HE++I + + +++ +++ + L L + + F Sbjct: 83 EIDILRTLYHEHIIKYKGCCEDAGAASLQ--LVMEYVPLGSLRDYLPRHSIGLAQLLLFA 140 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 QI G+ Y+HS + +HRDL N+L++ +KI DFGLA+ H++ + + Sbjct: 141 QQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP 200 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN 241 ++ APE + K Y S D+WS G L E+L++ Sbjct: 201 VFWYAPECLKEYKFYYAS-DVWSFGVTLYELLTH 233 >3ALO-A nrPDB Length = 327 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 71/303 (23%), Positives = 130/303 (42%), Gaps = 57/303 (18%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 IG GAYG V+ +A+K+I + ++ L ++ +++R I + Sbjct: 30 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYI----VQ 85 Query: 108 RASTLEAMRDVYIVQDLMETDLYKLLK------SQQLSNDHICYFLYQILRGLKYI-HSA 160 L D +I +LM T K K + + + ++ L ++ + Sbjct: 86 FYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENL 145 Query: 161 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA------TRWYRAPE 214 ++HRD+KPSN+L++ + ++K+CDFG+ +G L + +A R Y APE Sbjct: 146 KIIHRDIKPSNILLDRSGNIKLCDFGI----------SGQLVDSIAKTRDAGCRPYMAPE 195 Query: 215 IM---LNSKGYTKSIDIWSVGCILAEMLSNRPIFPG-KHYLDQLNHILGILGSPSQEDLN 270 + + +GY D+WS+G L E+ + R +P DQL + + G P Q Sbjct: 196 RIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQV--VKGDPPQ---- 249 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + N + R + S ++ ++ LT + +KR +E L HP++ Sbjct: 250 -LSNSEEREFSPSF-------------------INFVNLCLTKDESKRPKYKELLKHPFI 289 Query: 331 EQY 333 Y Sbjct: 290 LMY 292 >4IDT-A nrPDB Length = 356 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 60/205 (29%), Positives = 97/205 (47%), Gaps = 29/205 (14%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G G++G V D + A+KK+ L FR E ++ + Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVR-----------------LEVFRAEELMACAGLT 124 Query: 108 RASTLE---AMRD---VYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHS 159 + A+R+ V I +L+E L +L+K Q L D Y+L Q L GL+Y+HS Sbjct: 125 SPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHS 184 Query: 160 ANVLHRDLKPSNLLINT-TCDLKICDFGLARIADPEHDHTGFLT-EYV-ATRWYRAPEIM 216 +LH D+K N+L+++ +CDFG A P+ LT +Y+ T + APE++ Sbjct: 185 RRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVV 244 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSN 241 L K +D+WS C++ ML+ Sbjct: 245 LGRSCDAK-VDVWSSCCMMLHMLNG 268 >5HVK-A nrPDB Length = 315 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 97/209 (46%), Gaps = 21/209 (10%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT-LREIQILLRFRHENVIGIR 104 + +G+G +G + +K++ F+ +T QRT L+E++++ H NV+ Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEET--QRTFLKEVKVMRCLEHPNVLKFI 77 Query: 105 DILRASTLEAMRDVYIVQDLMETDLYKLLKS--QQLSNDHICYFLYQILRGLKYIHSANV 162 +L + R +I + + L ++KS Q F I G+ Y+HS N+ Sbjct: 78 GVL----YKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNI 133 Query: 163 LHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-----------YVATRWYR 211 +HR+L N L+ ++ + DFGLAR+ E L V ++ Sbjct: 134 IHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWM 193 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLS 240 APE M+N + Y + +D++S G +L E++ Sbjct: 194 APE-MINGRSYDEKVDVFSFGIVLCEIIG 221 >4Y83-A nrPDB Length = 332 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 100/210 (47%), Gaps = 16/210 (7%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 P+ + R +I GA+G V A D K R+A K I P + Q +++I Sbjct: 68 PWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLI-PVD-----QFKPSDVEIQAC 121 Query: 95 FRHENVIGIRD-ILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 FRHEN+ + +L T+ + ++E KL + I + +L+G Sbjct: 122 FRHENIAELYGAVLWGETVHLFMEAGEGGSVLE----KLESCGPMREFEIIWVTKHVLKG 177 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 L ++HS V+H D+KPSN++ +T + + DFGL+ + F + T Y +P Sbjct: 178 LDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMT---EDVYFPKDLRGTEIYMSP 233 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRP 243 E++L +G++ DI+S+G L M + P Sbjct: 234 EVIL-CRGHSTKADIYSLGATLIHMQTGTP 262 >5VO2-A nrPDB Length = 300 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 97/200 (48%), Gaps = 24/200 (12%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQI--LLRFRHENVIG 102 LQ++G GA G V H VA+KK+ R L+E I L + +H N+I Sbjct: 17 LQWVGSGAQGAVFLGRFH--GEEVAVKKV----------RDLKETDIKHLRKLKHPNIIT 64 Query: 103 IRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSAN 161 + + + + +++ + LY++L++ + ++ + + I G+ Y+H Sbjct: 65 FKGVCTQAPCYCI----LMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHK 120 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKG 221 ++HRDLK N+LI +KI DFG ++ E + T + APE++ N Sbjct: 121 IIHRDLKSPNMLITYDDVVKISDFGTSK----ELSDKSTKMSFAGTVAWMAPEVIRNEP- 175 Query: 222 YTKSIDIWSVGCILAEMLSN 241 ++ +DIWS G +L E+L+ Sbjct: 176 VSEKVDIWSFGVVLWELLTG 195 >5F9E-A nrPDB Length = 353 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 67/269 (24%), Positives = 119/269 (44%), Gaps = 40/269 (14%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISP----FEHQTYCQRTLREIQIL-LRFRHENV 100 + +G+G++G V A AIK + + C T+ E ++L L + H + Sbjct: 25 KMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVEC--TMVEKRVLSLAWEHPFL 82 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 + T + +++ V + + +Y + + ++ +I+ GL+++H Sbjct: 83 THM-----FCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLH 137 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLAR---IADPEHDHTGFLTEYVATRWYRAPEI 215 S +++RDLK N+L++ +KI DFG+ + + D + + E+ T Y APEI Sbjct: 138 SKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTN------EFCGTPDYIAPEI 191 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 +L K Y S+D WS G +L EML + F G+ +E+L I M Sbjct: 192 LLGQK-YNHSVDWWSFGVLLYEMLIGQSPFHGQ----------------DEEELFHSIRM 234 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKAL 304 Y + L + K KLF + K L Sbjct: 235 DNPFYPRWLEKEAKDLLVKLFVREPEKRL 263 >4E93-A nrPDB Length = 377 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 58/197 (29%), Positives = 94/197 (47%), Gaps = 12/197 (6%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 IG G +G V S T VA+K + L+E +IL ++ H N++ + + Sbjct: 122 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVC 181 Query: 108 RASTLEAMRDVYIVQDLMET-DLYKLLKSQ--QLSNDHICYFLYQILRGLKYIHSANVLH 164 + +YIV +L++ D L+++ +L + + G++Y+ S +H Sbjct: 182 TQK-----QPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIH 236 Query: 165 RDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 223 RDL N L+ LKI DFG++R AD + +G L + V +W APE LN Y+ Sbjct: 237 RDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQ-VPVKW-TAPE-ALNYGRYS 293 Query: 224 KSIDIWSVGCILAEMLS 240 D+WS G +L E S Sbjct: 294 SESDVWSFGILLWETFS 310 >3ORP-A nrPDB Length = 311 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 97/217 (44%), Gaps = 6/217 (2%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP--FEHQTYCQRTLREIQIL 92 P + RY + +G G V A D VA+K + ++ R RE Q Sbjct: 7 PSHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNA 66 Query: 93 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQ-QLSNDHICYFLYQI 150 H ++ + D A T A YIV + ++ L ++ ++ ++ + Sbjct: 67 AALNHPAIVAVYDTGEAET-PAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADA 125 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY 210 + L + H ++HRD+KP+N++I+ T +K+ DFG+AR + + T Y Sbjct: 126 CQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQY 185 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 247 +PE +S D++S+GC+L E+L+ P F G Sbjct: 186 LSPEQARGDSVDARS-DVYSLGCVLYEVLTGEPPFTG 221 >3DLS-A nrPDB Length = 335 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 90/208 (43%), Gaps = 25/208 (12%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ-------RTLREIQILL 93 +Y+ + +G GA+G V +A D + V +K I + C + EI IL Sbjct: 25 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILS 84 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-----DLYKLL-KSQQLSNDHICYFL 147 R H N+I + DI Q +ME DL+ + + +L Y Sbjct: 85 RVEHANIIKVLDIFENQGF--------FQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIF 136 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 Q++ + Y+ +++HRD+K N++I +K+ DFG A + + T Sbjct: 137 RQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYL----ERGKLFYTFCGT 192 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCIL 235 Y APE+++ + +++WS+G L Sbjct: 193 IEYCAPEVLMGNPYRGPELEMWSLGVTL 220 >4CSV-A nrPDB Length = 275 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 94/205 (45%), Gaps = 15/205 (7%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G G +G V VA+K + E + L+E QI+ + +H N++ + + Sbjct: 19 LGSGQFGEVYEGKWRNYNIEVAVKTLK--EGTMSVEEFLQEAQIMKKLKHPNLVQLYGVC 76 Query: 108 RASTLEAMRDVYIVQDLME----TDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 +YI+ + M D + + ++ + Q+ G+ Y+ S N + Sbjct: 77 TKEP-----PIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFI 131 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 223 HRDL N L+ +K+ DFGLAR+ + E ++T +W APE + ++ Sbjct: 132 HRDLAARNCLVGENNVVKVADFGLARLIN-EDEYTARAGAKFPIKW-TAPEAISYNRFSI 189 Query: 224 KSIDIWSVGCILAEMLSNRPI-FPG 247 KS D+W+ G +L E+ + + +PG Sbjct: 190 KS-DVWAFGILLWEIFTYGQVPYPG 213 >3UIU-A nrPDB Length = 306 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 67/279 (24%), Positives = 122/279 (43%), Gaps = 51/279 (18%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 G + +++ IG G +G V A + I+++ + ++ RE++ L + H Sbjct: 11 GMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRV-----KYNNEKAEREVKALAKLDHV 65 Query: 99 NVI---GIRDIL---------------------RASTLEAMRDVYIVQDLMETDLYKLL- 133 N++ G D + S+ + ++I + + + Sbjct: 66 NIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWI 125 Query: 134 ---KSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARI 190 + ++L QI +G+ YIHS ++HRDLKPSN+ + T +KI DFGL + Sbjct: 126 EKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGL--V 183 Query: 191 ADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML--SNRPIFPGK 248 ++D G T T Y +PE ++S+ Y K +D++++G ILAE+L + K Sbjct: 184 TSLKND--GKRTRSKGTLRYMSPE-QISSQDYGKEVDLYALGLILAELLHVCDTAFETSK 240 Query: 249 HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSK 287 + D + I ++ I + K + LQ L SK Sbjct: 241 FFTDLRDGI-----------ISDIFDKKEKTLLQKLLSK 268 >5FET-A nrPDB Length = 847 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 105/216 (48%), Gaps = 13/216 (6%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 IG G +G V + + R A+K +S + Q+ +++ + +++ IR + Sbjct: 541 IGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRLV- 599 Query: 108 RASTLEAMRDVYIVQDLMET-DLYKLL-KSQQLSNDHICYFLYQILRGLKYIHSANVLHR 165 T + Y + +L+ +LY + K LS ++L I+ ++Y+H N+++R Sbjct: 600 --RTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNIVYR 657 Query: 166 DLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 225 DLKP N+L++ +K+ DFG A+ G V T Y APE++L KGY + Sbjct: 658 DLKPENILLDKQGYVKLIDFGCAKKIQ------GRAYTLVGTPHYMAPEVIL-GKGYGCT 710 Query: 226 IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 261 +DIW++G L E + P+ G DQL IL Sbjct: 711 VDIWALGVCLYEFICG-PLPFGNDQEDQLEIFRDIL 745 >4AN9-A nrPDB Length = 301 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 39/110 (35%), Positives = 63/110 (57%), Gaps = 7/110 (6%) Query: 150 ILRGLKYIHSAN-VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 +++GL Y+ + ++HRD+KPSN+L+N+ ++K+CDFG++ E E+V TR Sbjct: 116 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDE-----MANEFVGTR 170 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL 258 Y +PE L Y+ DIWS+G L EM R P + L++I+ Sbjct: 171 SYMSPE-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIV 219 >1U59-A nrPDB Length = 287 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 97/200 (48%), Gaps = 16/200 (8%) Query: 48 IGEGAYGMVSSAYDHVRKTR--VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 +G G +G V +RK + VAIK + + + +RE QI+ + + ++ + Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 77 Query: 106 ILRASTLEAMRDVYIVQDLMETDLYKLL--KSQQLSNDHICYFLYQILRGLKYIHSANVL 163 + +A L + +++ L+K L K +++ ++ L+Q+ G+KY+ N + Sbjct: 78 VCQAEAL-----MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 132 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW---YRAPEIMLNSK 220 HRDL N+L+ KI DFGL++ + + T A +W + APE +N + Sbjct: 133 HRDLAARNVLLVNRHYAKISDFGLSKALGAD---DSYYTARSAGKWPLKWYAPEC-INFR 188 Query: 221 GYTKSIDIWSVGCILAEMLS 240 ++ D+WS G + E LS Sbjct: 189 KFSSRSDVWSYGVTMWEALS 208 >4HVI-A nrPDB Length = 314 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 105/222 (47%), Gaps = 13/222 (5%) Query: 44 QLQYI---GEGAYGMVS-SAYDHVRKTRVAIKKISPFEHQTYCQRT--LREIQILLRFRH 97 L+YI G+G +G V YD + A+ + +H Q+ REIQIL Sbjct: 11 HLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHS 70 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY--QILRGLK 155 + ++ R + +++R +++ L L L+ + D LY QI +G++ Sbjct: 71 DFIVKYRGVSYGPGRQSLR--LVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGME 128 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 Y+ S +HRDL N+L+ + +KI DFGLA++ + D+ + ++ APE Sbjct: 129 YLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPE- 187 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLS--NRPIFPGKHYLDQLN 255 L+ +++ D+WS G +L E+ + ++ P +L + Sbjct: 188 SLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMG 229 >5X02-A nrPDB Length = 347 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 60/224 (26%), Positives = 107/224 (47%), Gaps = 38/224 (16%) Query: 48 IGEGAYGMVSSAYDH-VRKT----RVAIKKISPFEHQTYCQRTLREIQILLRF-RHENVI 101 +G GA+G V +A + + KT +VA+K + + + + E++++ + HEN++ Sbjct: 56 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIV 115 Query: 102 GIRDILRASTLEAMRDVYIV-QDLMETDLYKLLKS--QQLSNDHICY------------- 145 ++L A TL +Y++ + DL L+S ++ S D I Y Sbjct: 116 ---NLLGACTLSG--PIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLN 170 Query: 146 ---------FLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 F YQ+ +G++++ + +HRDL N+L+ +KICDFGLAR + + Sbjct: 171 VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSN 230 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + + +W APE + YT D+WS G +L E+ S Sbjct: 231 YVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFS 272 >4XUF-A nrPDB Length = 297 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 60/224 (26%), Positives = 107/224 (47%), Gaps = 38/224 (16%) Query: 48 IGEGAYGMVSSAYDH-VRKT----RVAIKKISPFEHQTYCQRTLREIQILLRF-RHENVI 101 +G GA+G V +A + + KT +VA+K + + + + E++++ + HEN++ Sbjct: 17 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIV 76 Query: 102 GIRDILRASTLEAMRDVYIVQD-LMETDLYKLLKS--QQLSNDHICY------------- 145 ++L A TL +Y++ + DL L+S ++ S D I Y Sbjct: 77 ---NLLGACTLSG--PIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLN 131 Query: 146 ---------FLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 F YQ+ +G++++ + +HRDL N+L+ +KICDFGLAR + + Sbjct: 132 VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSN 191 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + + +W APE + YT D+WS G +L E+ S Sbjct: 192 YVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFS 233 >5LOH-A nrPDB Length = 341 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/263 (23%), Positives = 117/263 (44%), Gaps = 44/263 (16%) Query: 81 YCQRTLREIQILLRFRHENVIGIRDILRAS----------TLEAMRDVYIVQD-LMETDL 129 Y + +++ ++ + V RD L S +L++ +VY+V + L+ D+ Sbjct: 62 YAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDV 121 Query: 130 YKLLKSQQLSNDHICY-FLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLA 188 LL ++ + ++ ++ L Y+H ++HRDLKP N+LI+ +K+ DFGL+ Sbjct: 122 KSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLS 181 Query: 189 RIA-DPEHDHTGFLT--EYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 ++ + + + LT + T Y APE++L + + ++D W++G L E L+ P F Sbjct: 182 KVTLNRDINMMDILTTRTFCGTPDYLAPELLL-GRAHGPAVDWWALGVCLFEFLTGIPPF 240 Query: 246 PGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALD 305 + +P Q N + K + W + K A Sbjct: 241 NDE--------------TPQQVFQNIL--------------KRDIPWPEGEEKLSDNAQS 272 Query: 306 LLDRMLTFNPNKRITVEEALAHP 328 ++ +LT + KR ++E HP Sbjct: 273 AVEILLTIDDTKRAGMKELKRHP 295 >2OZO-A nrPDB Length = 613 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 51/200 (25%), Positives = 97/200 (48%), Gaps = 16/200 (8%) Query: 48 IGEGAYGMVSSAYDHVRKTR--VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 +G G +G V +RK + VAIK + + + +RE QI+ + + ++ + Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 Query: 106 ILRASTLEAMRDVYIVQDLMETDLYKLL--KSQQLSNDHICYFLYQILRGLKYIHSANVL 163 + +A L + +++ L+K L K +++ ++ L+Q+ G+KY+ N + Sbjct: 404 VCQAEAL-----MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW---YRAPEIMLNSK 220 HR+L N+L+ KI DFGL++ + + T A +W + APE +N + Sbjct: 459 HRNLAARNVLLVNRHYAKISDFGLSKALGAD---DSYYTARSAGKWPLKWYAPEC-INFR 514 Query: 221 GYTKSIDIWSVGCILAEMLS 240 ++ D+WS G + E LS Sbjct: 515 KFSSRSDVWSYGVTMWEALS 534 >6ED6-A nrPDB Length = 415 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 94/205 (45%), Gaps = 15/205 (7%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTL-REIQILLRFRHENV 100 Y ++ IG GA+G V + A+K +S FE E + ++ F + Sbjct: 90 YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW 149 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159 + + + R +Y+V + M DL L+ + + ++ +++ L IHS Sbjct: 150 V----VQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHS 205 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFL--TEYVATRWYRAPEIML 217 ++HRD+KP N+L++ LK+ DFG + D TG + V T Y +PE++ Sbjct: 206 MGLIHRDVKPDNMLLDKHGHLKLADFGTCM----KMDETGMVHCDTAVGTPDYISPEVLK 261 Query: 218 NSKG---YTKSIDIWSVGCILAEML 239 + G Y + D WSVG L EML Sbjct: 262 SQGGDGFYGRECDWWSVGVFLYEML 286 >5KKR-C nrPDB Length = 395 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 38/100 (38%), Positives = 60/100 (60%), Gaps = 10/100 (10%) Query: 150 ILRGLKYIHSAN-VLHRDLKPSNLLINTTCDLKICDFGLA-RIADPEHDHTGFLTEYVAT 207 +++GL Y+ + ++HRD+KPSN+L+N+ ++K+CDFG++ ++ D +V T Sbjct: 175 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID------SMANSFVGT 228 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR-PIFP 246 R Y +PE L Y+ DIWS+G L EM R PI P Sbjct: 229 RSYMSPE-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPP 267 >3HKO-A nrPDB Length = 345 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 53/197 (26%), Positives = 88/197 (44%), Gaps = 31/197 (15%) Query: 143 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLI--NTTCDLKICDFGLARIADPEHDHTGF 200 I + QI L Y+H+ + HRD+KP N L N + ++K+ DFGL++ ++ + Sbjct: 170 ISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYY 229 Query: 201 -LTEYVATRWYRAPEIM-LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL 258 +T T ++ APE++ ++ Y D WS G +L +L FPG + D ++ + Sbjct: 230 GMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQV- 288 Query: 259 GILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKR 318 LN + + NY P A DLL +L N ++R Sbjct: 289 ----------LNKKLCFENPNYNVLSPL----------------ARDLLSNLLNRNVDER 322 Query: 319 ITVEEALAHPYLEQYYD 335 AL HP++ Q+ D Sbjct: 323 FDAMRALQHPWISQFSD 339 >4RA4-A nrPDB Length = 355 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 41/142 (28%), Positives = 75/142 (52%), Gaps = 8/142 (5%) Query: 110 STLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDL 167 S + + +Y V + + +Y + + + ++ +I GL ++H +++RDL Sbjct: 88 SCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDL 147 Query: 168 KPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVATRWYRAPEIMLNSKGYTKSI 226 K N+++++ +KI DFG+ + EH G T + T Y APEI + + Y KS+ Sbjct: 148 KLDNVMLDSEGHIKIADFGMCK----EHMMDGVTTRTFCGTPDYIAPEI-IAYQPYGKSV 202 Query: 227 DIWSVGCILAEMLSNRPIFPGK 248 D W+ G +L EML+ +P F G+ Sbjct: 203 DWWAYGVLLYEMLAGQPPFDGE 224 >6BXI-A nrPDB Length = 333 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 66/248 (26%), Positives = 107/248 (43%), Gaps = 58/248 (23%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + L+ IG GA+G V R+ KK + Y + LR+ +L + + ++ Sbjct: 8 FESLKVIGRGAFGEV----------RLVQKKDTG---HVYAMKILRKADMLEKEQVGHIR 54 Query: 102 GIRDIL-RASTLEAMRDVYIVQD------LME----TDLYKLL-KSQQLSNDHICYFLYQ 149 RDIL A +L ++ Y QD +ME D+ LL K L+ + +++ + Sbjct: 55 AERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAE 114 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH--------DHT--- 198 + + IH +HRD+KP NLL+++ +K+ DFGL H +H+ Sbjct: 115 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 174 Query: 199 -----GFLTEYVATRWYR----------------APEIMLNSKGYTKSIDIWSVGCILAE 237 ++ A W R APE+ + + GY K D WS+G I+ E Sbjct: 175 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQT-GYNKLCDWWSLGVIMYE 233 Query: 238 MLSNRPIF 245 ML P F Sbjct: 234 MLIGYPPF 241 >3TT0-A nrPDB Length = 382 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/219 (28%), Positives = 106/219 (48%), Gaps = 33/219 (15%) Query: 48 IGEGAYGMVSSAY-------DHVRKTRVAIKKISPFEHQTYCQRTLREIQIL-LRFRHEN 99 +GEGA+G V A R T+VA+K + + + E++++ + +H+N Sbjct: 77 LGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 136 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS-----------------QQLSNDH 142 +I ++L A T + V IV+ + +L + L++ +QLS+ Sbjct: 137 II---NLLGACTQDGPLYV-IVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKD 192 Query: 143 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH-DHTGFL 201 + YQ+ RG++Y+ S +HRDL N+L+ +KI DFGLAR D H D+ Sbjct: 193 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR--DIHHIDYYKKT 250 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 T + APE + + + YT D+WS G +L E+ + Sbjct: 251 TNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFT 288 >3EQC-A nrPDB Length = 360 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 38/100 (38%), Positives = 60/100 (60%), Gaps = 10/100 (10%) Query: 150 ILRGLKYIHSAN-VLHRDLKPSNLLINTTCDLKICDFGLA-RIADPEHDHTGFLTEYVAT 207 +++GL Y+ + ++HRD+KPSN+L+N+ ++K+CDFG++ ++ D +V T Sbjct: 140 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID------SMANSFVGT 193 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR-PIFP 246 R Y +PE L Y+ DIWS+G L EM R PI P Sbjct: 194 RSYMSPE-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPP 232 >2PMN-X nrPDB Length = 348 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 69/257 (26%), Positives = 111/257 (43%), Gaps = 37/257 (14%) Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ----LSNDHI 143 E+QI+ ++E + I+ +VYI+ + ME D +LK + L ++ Sbjct: 93 ELQIITDIKNEYCLTCEGIITN-----YDEVYIIYEYMEND--SILKFDEYFFVLDKNYT 145 Query: 144 CYFLYQILR--------GLKYIHS-ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPE 194 C+ Q+++ YIH+ N+ HRD+KPSN+L++ +K+ DFG + E Sbjct: 146 CFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFG-----ESE 200 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKS-IDIWSVGCILAEMLSNRPIFPGKHYLDQ 253 + + T + PE N Y + +DIWS+G L M N F K L + Sbjct: 201 YMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVE 260 Query: 254 LNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTF 313 L + + D N ++L L +K D +D L L Sbjct: 261 LFNNIRTKNIEYPLDRN--------HFLYPLTNKKSTCSNNFLSNED---IDFLKLFLRK 309 Query: 314 NPNKRITVEEALAHPYL 330 NP +RIT E+AL H +L Sbjct: 310 NPAERITSEDALKHEWL 326 >4AF3-A nrPDB Length = 292 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 72/288 (25%), Positives = 122/288 (42%), Gaps = 48/288 (16%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 +G+G +G V A + VA+K + S E + + REI+I H N++ + + Sbjct: 31 LGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYN 90 Query: 106 ILRASTLEAMRDVYIVQDLM-ETDLYK-LLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 R +Y++ + +LYK L KS + ++ L Y H V+ Sbjct: 91 YFYDR-----RRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVI 145 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 223 HRD+KP NLL+ +LKI DFG + A T T Y PE M+ + + Sbjct: 146 HRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKT-----MCGTLDYLPPE-MIEGRMHN 199 Query: 224 KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQS 283 + +D+W +G + E+L P F + + I+ + DL Sbjct: 200 EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV-------DLK------------- 239 Query: 284 LPSKTKVAWAKLFPKS-DSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 FP S + A DL+ ++L NP++R+ + + AHP++ Sbjct: 240 ------------FPASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWV 275 >5HI2-A nrPDB Length = 283 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 101/218 (46%), Gaps = 17/218 (7%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 Q IG G++G V H VA+K ++P + Q + E+ +L + RH N++ Sbjct: 26 QRIGSGSFGTVYKGKWH---GDVAVKMLTPQQLQAFKN----EVGVLRKTRHVNILLFMG 78 Query: 106 ILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ--LSNDHICYFLYQILRGLKYIHSANVL 163 L + Q + LY L + + + Q RG+ Y+H+ +++ Sbjct: 79 YSTKPQL-----AIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSII 133 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI--MLNSKG 221 HRDLK +N+ ++ +KI DFGLA + F + W APE+ M +S Sbjct: 134 HRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM-APEVIRMQDSNP 192 Query: 222 YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 259 Y+ D+++ G +L E+++ + + + DQ+ ++G Sbjct: 193 YSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVG 230 >4G3E-A nrPDB Length = 352 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 96/205 (46%), Gaps = 29/205 (14%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G G++G V D + A+KK+ L FR E ++ + Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVR-----------------LEVFRVEELVACAGLS 124 Query: 108 RASTLE---AMRD---VYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHS 159 + A+R+ V I +L+E L +L+K L D Y+L Q L GL+Y+H+ Sbjct: 125 SPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHT 184 Query: 160 ANVLHRDLKPSNLLINTTCD-LKICDFGLARIADPEHDHTGFLT-EYV-ATRWYRAPEIM 216 +LH D+K N+L+++ +CDFG A P+ LT +Y+ T + APE++ Sbjct: 185 RRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVV 244 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSN 241 + K +DIWS C++ ML+ Sbjct: 245 MG-KPCDAKVDIWSSCCMMLHMLNG 268 >3GQL-A nrPDB Length = 326 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 62/219 (28%), Positives = 106/219 (48%), Gaps = 33/219 (15%) Query: 48 IGEGAYGMVSSAY-------DHVRKTRVAIKKISPFEHQTYCQRTLREIQIL-LRFRHEN 99 +GEGA+G V A R T+VA+K + + + E++++ + +H+N Sbjct: 36 LGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 95 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS-----------------QQLSNDH 142 +I ++L A T + V IV+ + +L + L++ +QLS+ Sbjct: 96 II---NLLGACTQDGPLYV-IVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 151 Query: 143 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH-DHTGFL 201 + YQ+ RG++Y+ S +HRDL N+L+ +KI DFGLAR D H D+ Sbjct: 152 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR--DIHHIDYYKKT 209 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 T + APE + + + YT D+WS G +L E+ + Sbjct: 210 TNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFT 247 >6HV0-A nrPDB Length = 416 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 83/296 (28%), Positives = 133/296 (44%), Gaps = 53/296 (17%) Query: 48 IGEGAYGMVSSAYDHVRKTR-VAIKKISPFEHQTYCQRTLREIQILLRF-RHENVIGIRD 105 +G GA G + Y + R VA+K+I P E ++ R E+Q+L H NVI Sbjct: 16 LGHGAEGTI--VYRGMFDNRDVAVKRILP-ECFSFADR---EVQLLRESDEHPNVI---- 65 Query: 106 ILRASTLEAMRDV-YIVQDLMETDLYKLLKSQQLSNDHI--CYFLYQILRGLKYIHSANV 162 R E R YI +L L + ++ + ++ + L Q GL ++HS N+ Sbjct: 66 --RYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNI 123 Query: 163 LHRDLKPSNLLI---NTTCDLK--ICDFGLA-RIADPEHDHTGFLTEYVATRWYRAPEIM 216 +HRDLKP N+LI N +K I DFGL ++A H + + T + APE++ Sbjct: 124 VHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSR-RSGVPGTEGWIAPEML 182 Query: 217 LN--SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 + T ++DI+S GC+ ++S GK Q N +LG L+C+ Sbjct: 183 SEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACS------LDCL-- 234 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 P K + D A +L+++M+ +P KR + + L HP+ Sbjct: 235 ---------HPEKHE----------DVIARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >2I0E-A nrPDB Length = 353 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 41/142 (28%), Positives = 76/142 (53%), Gaps = 8/142 (5%) Query: 110 STLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDL 167 S + M +Y V + + +Y + + + H ++ +I GL ++ S +++RDL Sbjct: 88 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 147 Query: 168 KPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVATRWYRAPEIMLNSKGYTKSI 226 K N+++++ +KI DFG+ + E+ G T+ + T Y APEI + + Y KS+ Sbjct: 148 KLDNVMLDSEGHIKIADFGMCK----ENIWDGVTTKTFCGTPDYIAPEI-IAYQPYGKSV 202 Query: 227 DIWSVGCILAEMLSNRPIFPGK 248 D W+ G +L EML+ + F G+ Sbjct: 203 DWWAFGVLLYEMLAGQAPFEGE 224 >4XCU-A nrPDB Length = 300 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 100/209 (47%), Gaps = 22/209 (10%) Query: 48 IGEGAYGMVSSA----YDHVR---KTRVAIKKISPFEHQTYCQRTLREIQIL-LRFRHEN 99 +GEG +G V A D R + VA+K + + E++++ L RH+N Sbjct: 25 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 84 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ--------LSNDHICYFLYQIL 151 +I ++L T E V IV+ + +L + L++++ LS + YQ+ Sbjct: 85 II---NLLGVCTQEGPLYV-IVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQVA 140 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 RG++Y+ S +HRDL N+L+ +KI DFGLAR + + +W Sbjct: 141 RGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWM- 199 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLS 240 APE + + + YT D+WS G +L E+ + Sbjct: 200 APEALFD-RVYTHQSDVWSFGILLWEIFT 227 >5XD6-A nrPDB Length = 305 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 65/216 (30%), Positives = 99/216 (45%), Gaps = 16/216 (7%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVA-IKKISPFEHQTYCQRTLREIQILLRF 95 D+ Y IGEG+YG V Y ++ + A IKK+ + Q L ++ ++ R Sbjct: 19 DITDNYGSKSLIGEGSYGRV--FYGILKSGKAAAIKKLDSSKQPD--QEFLAQVSMVSRL 74 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLY--KLLKSQQ----LSNDHICYFLYQ 149 R ENV+ + L + Y + L+ K +K Q LS Sbjct: 75 RQENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVG 134 Query: 150 ILRGLKYIH---SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 RGL+Y+H + +V+HRD+K SN+L+ KI DF L+ A P+ T + Sbjct: 135 AARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQA-PDMAARLHSTRVLG 193 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 242 T Y APE + TKS D++S G +L E+L+ R Sbjct: 194 TFGYHAPEYAMTGTLSTKS-DVYSFGVVLLELLTGR 228 >3VHK-A nrPDB Length = 368 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 40/115 (34%), Positives = 66/115 (57%), Gaps = 10/115 (8%) Query: 128 DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGL 187 DLYK L+ +H+ + +Q+ +G++++ S +HRDL N+L++ +KICDFGL Sbjct: 191 DLYKDF----LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGL 246 Query: 188 AR--IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 AR DP++ G + +W APE + + + YT D+WS G +L E+ S Sbjct: 247 ARDIYKDPDYVRKG--DARLPLKWM-APETIFD-RVYTIQSDVWSFGVLLWEIFS 297 >6E9W-A nrPDB Length = 443 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 70/282 (24%), Positives = 122/282 (43%), Gaps = 25/282 (8%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTL-REIQILLRFRHENV 100 Y ++ IG GA+G V + A+K +S FE E + ++ F + Sbjct: 104 YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW 163 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159 + + + R +Y+V + M DL L+ + + ++ +++ L IHS Sbjct: 164 V----VQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHS 219 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFL--TEYVATRWYRAPEIML 217 +HRD+KP N+L++ + LK+ DFG + E G + V T Y +PE++ Sbjct: 220 MGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKE----GMVRCDTAVGTPDYISPEVLK 275 Query: 218 NSKG---YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 + G Y + D WSVG L EML F + + I+ S + D N I+ Sbjct: 276 SQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDND-IS 334 Query: 275 MKARNYLQSLPSKTKVAWAK---------LFPKSDSKALDLL 307 +A+N + + + +V + LF K+D A + L Sbjct: 335 KEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETL 376 >3PFQ-A nrPDB Length = 674 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 41/142 (28%), Positives = 76/142 (53%), Gaps = 8/142 (5%) Query: 110 STLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDL 167 S + M +Y V + + +Y + + + H ++ +I GL ++ S +++RDL Sbjct: 409 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDL 468 Query: 168 KPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVATRWYRAPEIMLNSKGYTKSI 226 K N+++++ +KI DFG+ + E+ G T+ + T Y APEI + + Y KS+ Sbjct: 469 KLDNVMLDSEGHIKIADFGMCK----ENIWDGVTTKTFCGTPDYIAPEI-IAYQPYGKSV 523 Query: 227 DIWSVGCILAEMLSNRPIFPGK 248 D W+ G +L EML+ + F G+ Sbjct: 524 DWWAFGVLLYEMLAGQAPFEGE 545 >4OLI-A nrPDB Length = 645 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 96/202 (47%), Gaps = 7/202 (3%) Query: 44 QLQYIGEGAYGMVS-SAYDHVRKTR---VAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 +++ +GEG +G VS YD VA+K + + +EI IL HE+ Sbjct: 357 KIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEH 416 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159 +I + ++++ +++ + L L + + F QI G+ Y+HS Sbjct: 417 IIKYKGCCEDQGEKSLQ--LVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHS 474 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 + +HR+L N+L++ +KI DFGLA+ H++ + + ++ APE + Sbjct: 475 QHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEY 534 Query: 220 KGYTKSIDIWSVGCILAEMLSN 241 K Y S D+WS G L E+L++ Sbjct: 535 KFYYAS-DVWSFGVTLYELLTH 555 >4M66-A nrPDB Length = 325 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 105/208 (50%), Gaps = 17/208 (8%) Query: 44 QLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGI 103 +L+++G+G +G+V A+ VA+K ++ ++ E++ ++ R+ENV+ + Sbjct: 24 KLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN-------SKKISWEVKAMVNLRNENVLLL 76 Query: 104 RDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSAN 161 + + + +V ME L LL+ + +C L +++ G+ Y+HS + Sbjct: 77 LGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHSLD 136 Query: 162 --VLHRDLKPSNLLINTTCDLKICDFGLARI---ADPEHDHTGFLTEYVATRWYRAPEIM 216 +LHRDLKPSN+L++ K+ DFGL+ + + T Y PE++ Sbjct: 137 PPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELL 196 Query: 217 --LNSKGYTKSIDIWSVGCILAEMLSNR 242 +N K +K+ D++S G ++ +L+ R Sbjct: 197 FKVNLKA-SKASDVYSFGILVWAVLAGR 223 >1VZO-A nrPDB Length = 355 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 77/330 (23%), Positives = 149/330 (45%), Gaps = 55/330 (16%) Query: 4 AAAQGGGGGEPRRT---EGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVS--- 57 +A GG GGE T E + G E V + F++ L+ +G GAYG V Sbjct: 21 TSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFEL------LKVLGTGAYGKVFLVR 74 Query: 58 --SAYDHVRKTRVAI-KKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEA 114 S +D + + + KK + + + T E Q+L R + + + Sbjct: 75 KISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFL----VTLHYAFQT 130 Query: 115 MRDVYIVQDLMET-DLYKLLKSQQLSNDH-ICYFLYQILRGLKYIHSANVLHRDLKPSNL 172 ++++ D + +L+ L ++ +H + ++ +I+ L+++H +++RD+K N+ Sbjct: 131 ETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENI 190 Query: 173 LINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS-KGYTKSIDIWSV 231 L+++ + + DFGL++ + D T ++ T Y AP+I+ G+ K++D WS+ Sbjct: 191 LLDSNGHVVLTDFGLSK--EFVADETERAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSL 248 Query: 232 GCILAEMLSNRPIFPGKHYLDQLNHILGILGSP-SQEDLNCIINMKARNYLQSLPSKTKV 290 G ++ E+L+ F + G SQ ++ +R L+S P Sbjct: 249 GVLMYELLTGASPFT-------------VDGEKNSQAEI-------SRRILKSEPP---- 284 Query: 291 AWAKLFPKSDSK-ALDLLDRMLTFNPNKRI 319 +P+ S A DL+ R+L +P KR+ Sbjct: 285 -----YPQEMSALAKDLIQRLLMKDPKKRL 309 >5UUU-A nrPDB Length = 547 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 44/148 (29%), Positives = 76/148 (51%), Gaps = 12/148 (8%) Query: 120 IVQDLMET-DL-YKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT 177 + DLM DL Y L + S + ++ +I+ GL+++H+ V++RDLKP+N+L++ Sbjct: 278 FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEH 337 Query: 178 CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE 237 ++I D GLA + H V T Y APE++ Y S D +S+GC+L + Sbjct: 338 GHVRISDLGLACDFSKKKPHAS-----VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFK 392 Query: 238 MLSNRPIF-----PGKHYLDQLNHILGI 260 +L F KH +D++ + + Sbjct: 393 LLRGHSPFRQHKTKDKHEIDRMTLTMAV 420 >5KCV-A nrPDB Length = 460 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 66/254 (25%), Positives = 111/254 (43%), Gaps = 20/254 (7%) Query: 3 AAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDH 62 AAA G P G EV + K + + L+ +G+G +G V + Sbjct: 128 AAAEMDFRSGSPSDNSG---AEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEK 184 Query: 63 VRKTRVAIK--KISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120 A+K K + TL E ++L RH + L+ S R ++ Sbjct: 185 ATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTA----LKYSFQTHDRLCFV 240 Query: 121 VQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLKYIHS-ANVLHRDLKPSNLLINTTC 178 ++ +L+ L + + S D ++ +I+ L Y+HS NV++RDLK NL+++ Sbjct: 241 MEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG 300 Query: 179 DLKICDFGLAR--IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILA 236 +KI DFGL + I D + + T Y APE+ L Y +++D W +G ++ Sbjct: 301 HIKITDFGLCKEGIKD-----GATMKTFCGTPEYLAPEV-LEDNDYGRAVDWWGLGVVMY 354 Query: 237 EMLSNR-PIFPGKH 249 EM+ R P + H Sbjct: 355 EMMCGRLPFYNQDH 368 >5A46-A nrPDB Length = 386 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 105/219 (47%), Gaps = 33/219 (15%) Query: 48 IGEGAYGMVSSAY-------DHVRKTRVAIKKISPFEHQTYCQRTLREIQIL-LRFRHEN 99 +GEG +G V A R T+VA+K + + + E++++ + +H+N Sbjct: 48 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 107 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS-----------------QQLSNDH 142 +I ++L A T + V IV+ + +L + L++ +QLS+ Sbjct: 108 II---NLLGACTQDGPLYV-IVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 163 Query: 143 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH-DHTGFL 201 + YQ+ RG++Y+ S +HRDL N+L+ +KI DFGLAR D H D+ Sbjct: 164 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR--DIHHIDYYKKT 221 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 T + APE + + + YT D+WS G +L E+ + Sbjct: 222 TNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFT 259 >2JDO-A nrPDB Length = 342 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 58/246 (23%), Positives = 109/246 (44%), Gaps = 35/246 (14%) Query: 129 LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLA 188 + L + + + + ++ +I+ L+Y+HS +V++RD+K NL+++ +KI DFGL Sbjct: 98 FFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLC 157 Query: 189 R--IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR-PIF 245 + I+D + + T Y APE+ L Y +++D W +G ++ EM+ R P + Sbjct: 158 KEGISD-----GATMKTFCGTPEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 211 Query: 246 PGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPK------- 298 H E L +I M+ + ++L + K A L K Sbjct: 212 NQDH-----------------ERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLG 254 Query: 299 -SDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK 357 S A ++++ + N + V++ L P+ Q D ++ FT A + P Sbjct: 255 GGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFT-AQSITITPP 313 Query: 358 ERLKEL 363 +R L Sbjct: 314 DRYDSL 319 >3PVW-A nrPDB Length = 695 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 44/148 (29%), Positives = 76/148 (51%), Gaps = 12/148 (8%) Query: 120 IVQDLMET-DL-YKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT 177 + DLM DL Y L + S + ++ +I+ GL+++H+ V++RDLKP+N+L++ Sbjct: 269 FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEH 328 Query: 178 CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE 237 ++I D GLA + H V T Y APE++ Y S D +S+GC+L + Sbjct: 329 GHVRISDLGLACDFSKKKPHAS-----VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFK 383 Query: 238 MLSNRPIF-----PGKHYLDQLNHILGI 260 +L F KH +D++ + + Sbjct: 384 LLRGHSPFRQHKTKDKHEIDRMTLTMAV 411 >3MV5-A nrPDB Length = 342 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 100/215 (46%), Gaps = 17/215 (7%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIK--KISPFEHQTYCQRTLREIQILLRFRHEN 99 + L+ +G+G +G V + A+K K + TL E ++L RH Sbjct: 12 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 71 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLKYIH 158 + L+ S R ++++ +L+ L + + S D ++ +I+ L Y+H Sbjct: 72 LTA----LKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 127 Query: 159 S-ANVLHRDLKPSNLLINTTCDLKICDFGLAR--IADPEHDHTGFLTEYVATRWYRAPEI 215 S NV++RDLK NL+++ +KI DFGL + I D + + T Y APE+ Sbjct: 128 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD-----GATMKTFCGTPEYLAPEV 182 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKH 249 L Y +++D W +G ++ EM+ R P + H Sbjct: 183 -LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 216 >5O0Y-A nrPDB Length = 579 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 80/315 (25%), Positives = 128/315 (40%), Gaps = 53/315 (16%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAI------KKISPFEHQTYCQRTLREIQI 91 + RY L +G G + V A+D + VA+ K + + Y + RE +I Sbjct: 282 LNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRI 341 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQL-SNDHICYFLYQI 150 H ++ + D +L+ +++ DL LK +L S + QI Sbjct: 342 HKELDHPRIVKLYDYF---SLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQI 398 Query: 151 LRGLKYIHSAN--VLHRDLKPSNLLI--NTTC-DLKICDFGLARIADPEH----DHTGFL 201 + LKY++ ++H DLKP N+L+ T C ++KI DFGL++I D + D Sbjct: 399 VNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELT 458 Query: 202 TEYVATRWYRAPEIMLNSK---GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL 258 ++ T WY PE + K + +D+WSVG I + L R F Sbjct: 459 SQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG------------ 506 Query: 259 GILGSPSQEDL---NCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 315 + SQ+D+ N I+ +Q P AK F + R L + Sbjct: 507 ---HNQSQQDILQENTILKATE---VQFPPKPVVTPEAKAF----------IRRCLAYRK 550 Query: 316 NKRITVEEALAHPYL 330 RI V++ PYL Sbjct: 551 EDRIDVQQLACDPYL 565 >3OMV-A nrPDB Length = 307 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 58/236 (24%), Positives = 106/236 (44%), Gaps = 15/236 (6%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 IG G++G V H +K + P Q R E+ +L + RH N++ + Sbjct: 44 IGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRN--EVAVLRKTRHVNILLFMGYM 101 Query: 108 RASTLEAMRDVYIVQDLMETDLYKLLKSQQLSND--HICYFLYQILRGLKYIHSANVLHR 165 L + Q + LYK L Q+ + Q +G+ Y+H+ N++HR Sbjct: 102 TKDNL-----AIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHR 156 Query: 166 DLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI--MLNSKGYT 223 D+K +N+ ++ +KI DFGLA + + + + + + APE+ M ++ ++ Sbjct: 157 DMKSNNIFLHEGLTVKIGDFGLATVKS-RWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFS 215 Query: 224 KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI-LGSPSQEDL--NCIINMK 276 D++S G +L E+++ + + DQ+ ++G SP L NC MK Sbjct: 216 FQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMK 271 >5WNL-A nrPDB Length = 342 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 61/214 (28%), Positives = 100/214 (46%), Gaps = 11/214 (5%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95 FD G + + +G G +G V KT +AIK SP H +R +++L Sbjct: 17 FDAG-EFAGWEKVGSGGFGQVYKVRHVHWKTWLAIK-CSPSLHVDDRER----MELLEEA 70 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDHICYFLYQILRGL 154 + + R IL + V +V + MET L KLL S+ L D +++ G+ Sbjct: 71 KKMEMAKFRYILPVYGI-CQEPVGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGM 129 Query: 155 KYIH--SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 ++H S +LH +LKP+N+L++ +KI DFGLA+ H H + T Y Sbjct: 130 NFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLP 189 Query: 213 PE-IMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 PE I S+ + D++S ++ +L+ + F Sbjct: 190 PERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPF 223 >4PL5-B nrPDB Length = 435 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 78/295 (26%), Positives = 128/295 (43%), Gaps = 51/295 (17%) Query: 48 IGEGAYGMVSSAYDHVRKTR-VAIKKISPFEHQTYCQRTLREIQILLRF-RHENVIGIRD 105 +G GA G + Y + R VA+K+I P E ++ R E+Q+L H NVI Sbjct: 35 LGHGAEGTI--VYKGMFDNRDVAVKRILP-ECFSFADR---EVQLLRESDEHPNVI---- 84 Query: 106 ILRASTLEAMRDV-YIVQDLMETDLYKLLKSQQLSNDHI--CYFLYQILRGLKYIHSANV 162 R E R YI +L L + ++ + ++ + L+Q GL ++HS N+ Sbjct: 85 --RYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNI 142 Query: 163 LHRDLKPSNLLI---NTTCDLK--ICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 +HRDLKP N+L+ N +K I DFGL + + T + APE++ Sbjct: 143 VHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLS 202 Query: 218 N--SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 T ++DI+S GC+ ++S GK Q N +LG +L+C + Sbjct: 203 EDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGAC------NLDCFHSD 256 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 K D A +L+++M+ +P +R + + L HP+ Sbjct: 257 K---------------------HEDVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >3KUL-B nrPDB Length = 325 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 91/200 (45%), Gaps = 14/200 (7%) Query: 48 IGEGAYGMVSSAYDHV---RKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 IG G G V V R VAIK + + + L E I+ +F H N+I + Sbjct: 57 IGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLE 116 Query: 105 DILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSAN 161 ++ L IV + ME D + Q + + L + G++Y+ Sbjct: 117 GVVTRGRL-----AMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLG 171 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLT-EYVATRWYRAPEIMLNSK 220 +HRDL N+L+++ K+ DFGL+R+ + + D T + RW APE + + Sbjct: 172 YVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRW-TAPE-AIAFR 229 Query: 221 GYTKSIDIWSVGCILAEMLS 240 ++ + D+WS G ++ E+L+ Sbjct: 230 TFSSASDVWSFGVVMWEVLA 249 >3QGY-A nrPDB Length = 286 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 50/204 (24%), Positives = 95/204 (46%), Gaps = 12/204 (5%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 T +Q IG G +G+V Y + K +VAIK I E + E +++++ H ++ Sbjct: 30 TFVQEIGSGQFGLVHLGY-WLNKDKVAIKTIK--EGSMSEDDFIEEAEVMMKLSHPKLVQ 86 Query: 103 IRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ--LSNDHICYFLYQILRGLKYIHSA 160 + + LE + + + L L++Q+ + + + + G+ Y+ A Sbjct: 87 LYGV----CLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEA 142 Query: 161 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 V+HRDL N L+ +K+ DFG+ R + + T++ +W +PE+ S+ Sbjct: 143 CVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKF-PVKW-ASPEVFSFSR 200 Query: 221 GYTKSIDIWSVGCILAEMLSNRPI 244 Y+ D+WS G ++ E+ S I Sbjct: 201 -YSSKSDVWSFGVLMWEVFSEGKI 223 >3A8W-A nrPDB Length = 345 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 64/284 (22%), Positives = 128/284 (45%), Gaps = 38/284 (13%) Query: 42 YTQLQYIGEGAYGMVS----SAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 + L+ IG G+Y V D + +V K++ + +T + + H Sbjct: 11 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHV-FEQASNH 69 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDL-YKLLKSQQLSNDHICYFLYQILRGLKY 156 ++G+ + + R ++++ + DL + + + ++L +H ++ +I L Y Sbjct: 70 PFLVGLHSCFQTES----RLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNY 125 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 +H +++RDLK N+L+++ +K+ D+G+ + D T + + T Y APEI Sbjct: 126 LHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT---STFCGTPNYIAPEI- 181 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 L + Y S+D W++G ++ EM++ R F I+GS D N Sbjct: 182 LRGEDYGFSVDWWALGVLMFEMMAGRSPF-------------DIVGSSDNPDQN------ 222 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDS-KALDLLDRMLTFNPNKRI 319 +YL + + ++ P+S S KA +L L +P +R+ Sbjct: 223 TEDYLFQVILEKQIR----IPRSLSVKAASVLKSFLNKDPKERL 262 >3BEA-A nrPDB Length = 333 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 59/215 (27%), Positives = 100/215 (46%), Gaps = 29/215 (13%) Query: 48 IGEGAYGMVSSAY-------DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF-RHEN 99 +G GA+G V A D V K VA+K + H + + E++I+ +HEN Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLK--VAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 111 Query: 100 VIGIRDILRAST----LEAMRDVYIVQDLM----------ETDLYKLLKSQQLSNDHICY 145 ++ ++L A T + + + DL+ ETD + + LS + + Sbjct: 112 IV---NLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLH 168 Query: 146 FLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYV 205 F Q+ +G+ ++ S N +HRD+ N+L+ KI DFGLAR + ++ + Sbjct: 169 FSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARL 228 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 +W APE + + YT D+WS G +L E+ S Sbjct: 229 PVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFS 261 >5EG3-A nrPDB Length = 334 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 79/308 (25%), Positives = 138/308 (44%), Gaps = 65/308 (21%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-------------EIQIL-L 93 +GEGA+G V V V I K P E T + L+ E++++ + Sbjct: 43 LGEGAFGQV------VMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM 96 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS-----------------Q 136 +H+N+I ++L A T + V IV + +L + L++ + Sbjct: 97 IGKHKNII---NLLGACTQDGPLYV-IVAYASKGNLREYLRARRPPGMELSPDINRVPEE 152 Query: 137 QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 Q++ + YQ+ RG++Y+ S +HRDL N+L+ +KI DFGLAR + + Sbjct: 153 QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLAR----DIN 208 Query: 197 HTGFLTEYVATRW---YRAPEIMLNSKGYTKSIDIWSVGCILAEM--LSNRPIFPGKHYL 251 + F E R + APE + + + YT D+WS G ++ E+ L P +PG + Sbjct: 209 NIDFFKETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSP-YPGIP-V 265 Query: 252 DQLNHILGILGSPSQEDLNCI--INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDR 309 ++L +L G + NC + M R+ ++PS+ + ++ LDR Sbjct: 266 EELFKLLK-EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF---------KQLVEDLDR 315 Query: 310 MLTFNPNK 317 +LT N+ Sbjct: 316 ILTLTTNE 323 >3PLS-A nrPDB Length = 298 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/207 (28%), Positives = 98/207 (47%), Gaps = 24/207 (11%) Query: 48 IGEGAYGMV-SSAYDHVRKTRV--AIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 IG+G +G+V Y + R+ AIK +S + LRE ++ H NV+ + Sbjct: 29 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALI 88 Query: 105 DILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLS---NDHICYFLYQILRGLKYIHSAN 161 I+ E + V ++ + DL + ++S Q + D I + L Q+ RG++Y+ Sbjct: 89 GIMLPP--EGLPHV-LLPYMCHGDLLQFIRSPQRNPTVKDLISFGL-QVARGMEYLAEQK 144 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLAR-IADPE------HDHTGFLTEYVATRWYRAPE 214 +HRDL N +++ + +K+ DFGLAR I D E H H ++ A Sbjct: 145 FVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALE------ 198 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSN 241 L + +T D+WS G +L E+L+ Sbjct: 199 -SLQTYRFTTKSDVWSFGVLLWELLTR 224 >3LLT-A nrPDB Length = 360 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/248 (24%), Positives = 101/248 (40%), Gaps = 54/248 (21%) Query: 129 LYKLLKSQQLSNDHI---CYFLYQILRGLKYIHSANVLHRDLKPSNLLIN---------- 175 LY+++ + HI + +IL+ L Y+ ++ H DLKP N+L++ Sbjct: 122 LYEIITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLIT 181 Query: 176 ---------------TTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 + +K+ DFG A H + TR YRAPE++LN Sbjct: 182 VRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSDYHGSI------INTRQYRAPEVILNL- 234 Query: 221 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNY 280 G+ S D+WS GC+LAE+ + +F +++ L + I+ + L Y Sbjct: 235 GWDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKY 294 Query: 281 LQSLPSKTKVAWAKLFPKSDS-----KAL------------DLLDRMLTFNPNKRITVEE 323 + + K+AW + +S K L D L +L +P R + E Sbjct: 295 VNK--DELKLAWPENASSINSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAE 352 Query: 324 ALAHPYLE 331 L H +LE Sbjct: 353 LLKHKFLE 360 >4XI2-A nrPDB Length = 446 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 100/211 (47%), Gaps = 19/211 (9%) Query: 36 FDVGPR-YTQLQYIGEGAYGMVSSAYDHVR-KTRVAIKKISPFEHQTYCQRTLREIQILL 93 +++ P+ T L+ +G G +G+V Y R + VAIK I E + E ++++ Sbjct: 182 WEIDPKDLTFLKELGTGQFGVVK--YGKWRGQYDVAIKMIR--EGSMSEDEFIEEAKVMM 237 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLKS--QQLSNDHICYFLYQI 150 HE ++ + + R ++I+ + M L L+ + + + Sbjct: 238 NLSHEKLVQLYGVCTKQ-----RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDV 292 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRW 209 ++Y+ S LHRDL N L+N +K+ DFGL+R + D E +T + RW Sbjct: 293 CEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDE--YTSSVGSKFPVRW 350 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 PE+++ SK +KS DIW+ G ++ E+ S Sbjct: 351 -SPPEVLMYSKFSSKS-DIWAFGVLMWEIYS 379 >4C59-A nrPDB Length = 340 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 103/225 (45%), Gaps = 23/225 (10%) Query: 33 GQPFDVGP-RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQI 91 GQ ++G R + + EG + V A D A+K++ E + + ++E+ Sbjct: 19 GQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKN-RAIIQEVCF 77 Query: 92 LLRFR-HENVI---GIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ----LSNDHI 143 + + H N++ I + + + ++ +L + L + LK + LS D + Sbjct: 78 MKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTV 137 Query: 144 CYFLYQILRGLKYIHSAN--VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTG-- 199 YQ R ++++H ++HRDLK NLL++ +K+CDFG A D++ Sbjct: 138 LKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSA 197 Query: 200 ---FLTEYVATR----WYRAPEI--MLNSKGYTKSIDIWSVGCIL 235 L E TR YR PEI + ++ + DIW++GCIL Sbjct: 198 QRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCIL 242 >5TOS-A nrPDB Length = 395 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 88/331 (26%), Positives = 145/331 (43%), Gaps = 72/331 (21%) Query: 48 IGEGAYGMVSSAY---DHVRKTR------VAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 IGEG +G V + + T+ +A+KK++ Q + + L EI L + H Sbjct: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQLSHP 131 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHI----CYF--LYQILR 152 N++ + Y ++D +Y+ ++ L N H+ YF L LR Sbjct: 132 NLVKLIG-------------YCLEDEHRLLVYEFMQKGSLEN-HLFRRGAYFKPLPWFLR 177 Query: 153 ---------GLKYIHS--ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFL 201 GL ++HS V++RD+K SN+L++ + K+ DFGLAR P D + Sbjct: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG-PMGDLSYVS 236 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 261 T + T Y APE M + +S D++S G +L E+LS GK LD Sbjct: 237 TRVMGTYGYAAPEYMSSGHLNARS-DVYSFGVLLLEILS------GKRALDH-------- 281 Query: 262 GSPSQEDLNCIINMKARNYLQSLPSKTKVAW-------AKLFPKSDSKALDLLDRMLTFN 314 P++E+ +++ AR YL SK KV + P+ + + + L+F Sbjct: 282 NRPAKEE--NLVDW-ARPYLT---SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFE 335 Query: 315 PNKRITVEEALAHPYLEQYYDPTDEPVAEEP 345 P R T+++ + L+Q D +P P Sbjct: 336 PKSRPTMDQVVRA--LQQLQDNLGKPSQTNP 364 >6E4F-A nrPDB Length = 290 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 100/211 (47%), Gaps = 19/211 (9%) Query: 36 FDVGPR-YTQLQYIGEGAYGMVSSAYDHVR-KTRVAIKKISPFEHQTYCQRTLREIQILL 93 +++ P+ T L+ +G G +G+V Y R + VAIK I E + E ++++ Sbjct: 26 WEIDPKDLTFLKELGTGQFGVVK--YGKWRGQYDVAIKMIK--EGSMSEDEFIEEAKVMM 81 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLKS--QQLSNDHICYFLYQI 150 HE ++ + + R ++I+ + M L L+ + + + Sbjct: 82 NLSHEKLVQLYGVCTKQ-----RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDV 136 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRW 209 ++Y+ S LHRDL N L+N +K+ DFGL+R + D E +T + RW Sbjct: 137 CEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDE--YTSSVGSKFPVRW 194 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 PE+++ SK +KS DIW+ G ++ E+ S Sbjct: 195 -SPPEVLMYSKFSSKS-DIWAFGVLMWEIYS 223 >4NEU-A nrPDB Length = 333 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 103/208 (49%), Gaps = 24/208 (11%) Query: 51 GAYGMVSSAYDHVRK---TRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 G +G VS + + + K + EH + L E +++ R RH V+ + ++ Sbjct: 35 GGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHN---EALLEEAKMMNRLRHSRVVKLLGVI 91 Query: 108 RASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHI-CYFLYQILRGLKYIHSANVLHRD 166 +E + +++ + + +L +LK++ + + + +I+ G+ Y+H V+H+D Sbjct: 92 ----IEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKD 147 Query: 167 LKPSNLLINTTCDLKICDFGLA------RIADPEHDH----TGFLTEYVATRWYRAPEIM 216 LKP N+L++ +KI D GLA ++ + EH+ G + T +Y APE + Sbjct: 148 LKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHL 207 Query: 217 --LNSKGYTKSIDIWSVGCILAEMLSNR 242 +N+K KS D++S +L + +N+ Sbjct: 208 NDVNAKPTEKS-DVYSFAVVLWAIFANK 234 >3KRL-A nrPDB Length = 335 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 102/216 (47%), Gaps = 29/216 (13%) Query: 48 IGEGAYGMV--SSAYDHVRKT---RVAIKKISPFEHQTYCQRTLREIQILLRF-RHENVI 101 +G GA+G V ++A+ ++ +VA+K + H + + E++I+ +HEN++ Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 113 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLK-----------------SQQLSNDHIC 144 ++L A T + I + DL L+ +QLS+ + Sbjct: 114 ---NLLGACT-HGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLL 169 Query: 145 YFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEY 204 +F Q+ +G+ ++ S N +HRD+ N+L+ KI DFGLAR + ++ Sbjct: 170 HFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNAR 229 Query: 205 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + +W APE + + YT D+WS G +L E+ S Sbjct: 230 LPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFS 263 >6HXF-B nrPDB Length = 302 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 73/291 (25%), Positives = 121/291 (41%), Gaps = 46/291 (15%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G+GA+G V A + +A K+ + + + + EI+IL H ++ +L Sbjct: 27 LGDGAFGKVYKAKNK-ETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIV---KLL 82 Query: 108 RASTLEAMRDVYIVQDLM---ETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLH 164 A + ++I+ + D L + L+ I Q+L L ++HS ++H Sbjct: 83 GAYYHDG--KLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIH 140 Query: 165 RDLKPSNLLINTTCDLKICDFGL-ARIADPEHDHTGFLTEYVATRWYRAPEIM----LNS 219 RDLK N+L+ D+++ DFG+ A+ F + T ++ APE++ + Sbjct: 141 RDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSF----IGTPYWMAPEVVMCETMKD 196 Query: 220 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN 279 Y DIWS+G L EM I P H L+ + +L I S L Sbjct: 197 TPYDYKADIWSLGITLIEMAQ---IEPPHHELNPMRVLLKIAKSDPPTLLT--------- 244 Query: 280 YLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 PSK W+ F D L L NP R + + L HP++ Sbjct: 245 -----PSK----WSVEF-------RDFLKIALDKNPETRPSAAQLLEHPFV 279 >3QD2-B nrPDB Length = 332 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 35/107 (32%), Positives = 58/107 (54%), Gaps = 11/107 (10%) Query: 143 ICYFLY-QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFL 201 +C ++ QI ++++HS ++HRDLKPSN+ +K+ DFGL D + + L Sbjct: 165 VCLHIFIQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVL 224 Query: 202 TEY---------VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239 T V T+ Y +PE ++ Y+ +DI+S+G IL E+L Sbjct: 225 TPMPAYATHTGQVGTKLYMSPE-QIHGNNYSHKVDIFSLGLILFELL 270 Score = 34.3 bits (77), Expect = 0.093, Method: Compositional matrix adjust. Identities = 15/60 (25%), Positives = 31/60 (51%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + +Q +G G +G+V A + V AIK+I + ++ +RE++ L + H ++ Sbjct: 8 FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV 67 >3C51-A nrPDB Length = 543 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 34/101 (33%), Positives = 59/101 (58%), Gaps = 4/101 (3%) Query: 145 YFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEY 204 ++ QI+ GL+++H N+++RDLKP N+L++ +++I D GLA T Y Sbjct: 293 FYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKT---KGY 349 Query: 205 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 T + APE++L + Y S+D +++G L EM++ R F Sbjct: 350 AGTPGFMAPELLLGEE-YDFSVDYFALGVTLYEMIAARGPF 389 >3NYO-A nrPDB Length = 576 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 36/101 (35%), Positives = 60/101 (59%), Gaps = 5/101 (4%) Query: 145 YFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEY 204 ++ +I GL+ +H +++RDLKP N+L++ ++I D GLA + PE + Sbjct: 290 FYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA-VHVPEGQT---IKGR 345 Query: 205 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 V T Y APE++ N + YT S D W++GC+L EM++ + F Sbjct: 346 VGTVGYMAPEVVKNER-YTFSPDWWALGCLLYEMIAGQSPF 385 >2PSQ-A nrPDB Length = 370 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 75/310 (24%), Positives = 129/310 (41%), Gaps = 69/310 (22%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-------------EIQILLR 94 +GEG +G V V V I K P E T + L+ E++++ Sbjct: 89 LGEGCFGQV------VMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM 142 Query: 95 F-RHENVIGI----------------------RDILRASTLEAMRDVYIVQDLMETDLYK 131 +H+N+I + R+ LRA M Y + + E Sbjct: 143 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE----- 197 Query: 132 LLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA 191 +Q++ + YQ+ RG++Y+ S +HRDL N+L+ +KI DFGLAR Sbjct: 198 ----EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI 253 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM--LSNRPIFPGKH 249 + + + +W APE + + + YT D+WS G ++ E+ L P +PG Sbjct: 254 NNIDYYKKTTNGRLPVKWM-APEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSP-YPGIP 310 Query: 250 YLDQLNHILGILGSPSQEDLNCI--INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLL 307 +++L +L G + NC + M R+ ++PS+ + ++ L Sbjct: 311 -VEELFKLLK-EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF---------KQLVEDL 359 Query: 308 DRMLTFNPNK 317 DR+LT N+ Sbjct: 360 DRILTLTTNE 369 >4E20-A nrPDB Length = 290 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 54/198 (27%), Positives = 90/198 (45%), Gaps = 9/198 (4%) Query: 48 IGEGAYGMVS-SAYDHVRK---TRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGI 103 +GEG +G VS YD VA+K + REI+IL HE+++ Sbjct: 16 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKY 75 Query: 104 RDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANV 162 + + + V +V + + L L + + F QI G+ Y+H+ + Sbjct: 76 KGCCED---QGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQHY 132 Query: 163 LHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 +HR L N+L++ +KI DFGLA+ H++ + + ++ APE + K Y Sbjct: 133 IHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFY 192 Query: 223 TKSIDIWSVGCILAEMLS 240 S D+WS G L E+L+ Sbjct: 193 YAS-DVWSFGVTLYELLT 209 >5O2C-A nrPDB Length = 380 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 101/209 (48%), Gaps = 32/209 (15%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAI-----KKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 +G GA+ V D VA +K++ E Q + + E ++L +H N++ Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKE----EAEMLKGLQHPNIVR 88 Query: 103 IRDILRASTLEAMRDVYIVQDLMETDL-------YKLLKSQQLSNDHICYFLYQILRGLK 155 D S L+ + + +V +LM + +K++K + L + + QIL+GL+ Sbjct: 89 FYDSWE-SILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRS-----WCRQILKGLQ 142 Query: 156 YIHSAN--VLHRDLKPSNLLINT-TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 ++H+ ++HRDLK N+ I T +KI D GLA + T F + T + A Sbjct: 143 FLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM-----RTSFAKSVIGTPEFMA 197 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSN 241 PE+ + Y +S+D+++ G + EM ++ Sbjct: 198 PEMY--EEHYDESVDVYAFGMCMLEMATS 224 >2H34-A nrPDB Length = 309 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 73/249 (29%), Positives = 107/249 (42%), Gaps = 15/249 (6%) Query: 21 GPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF--EH 78 G + G E +G F GP Y + +G G G V A D VR+ VA+K +S Sbjct: 18 GSHMDGTAESREGTQF--GP-YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSD 74 Query: 79 QTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ 137 + R RE + R + +V+ I D E +Y+ L+ DL +L+ Q Sbjct: 75 PVFRTRMQREARTAGRLQEPHVVPIHDFG-----EIDGQLYVDMRLINGVDLAAMLRRQG 129 Query: 138 -LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 L+ + QI L H+A HRD+KP N+L++ + DFG+A E Sbjct: 130 PLAPPRAVAIVRQIGSALDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDE-- 187 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 L V T +Y APE S T DI+++ C+L E L+ P + G H Sbjct: 188 KLTQLGNTVGTLYYMAPERFSESHA-TYRADIYALTCVLYECLTGSPPYQGDQLSVMGAH 246 Query: 257 ILGILGSPS 265 I + PS Sbjct: 247 INQAIPRPS 255 >5O2B-A nrPDB Length = 285 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 100/209 (47%), Gaps = 32/209 (15%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAI-----KKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 +G GA+ V D VA +K++ E Q R E ++L +H N++ Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQ----RFKEEAEMLKGLQHPNIVR 79 Query: 103 IRDILRASTLEAMRDVYIVQDLMETDL-------YKLLKSQQLSNDHICYFLYQILRGLK 155 D S L+ + + +V +LM + +K++K + L + + QIL+GL+ Sbjct: 80 FYDSWE-SILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRS-----WCRQILKGLQ 133 Query: 156 YIHSAN--VLHRDLKPSNLLINT-TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 ++H+ ++HRDLK N+ I T +KI D GLA + T F + T + A Sbjct: 134 FLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM-----RTSFAKSVIGTPEFMA 188 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSN 241 PE + + Y +S+D+++ G + EM ++ Sbjct: 189 PE--MYEEHYDESVDVYAFGMCMLEMATS 215 >4K33-A nrPDB Length = 325 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 59/225 (26%), Positives = 104/225 (46%), Gaps = 31/225 (13%) Query: 41 RYTQLQYIGEGAYGMVSSA----YDHVRKTR---VAIKKISPFEHQTYCQRTLREIQIL- 92 R T + +GEGA+G V A D R + VA+K + + E++++ Sbjct: 37 RLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMK 96 Query: 93 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS----------------- 135 + +H+N+I ++L A T V +V+ + +L + L++ Sbjct: 97 MIGKHKNII---NLLGACTQGGPLYV-LVEYAAKGNLREFLRARRPPGLDYSFDTSKPPE 152 Query: 136 QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH 195 +QL+ + YQ+ RG++Y+ S +HRDL N+L+ +KI DFGLAR Sbjct: 153 EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLD 212 Query: 196 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + + +W APE + + + YT D+WS G +L E+ + Sbjct: 213 YYKETTNGRLPVKWM-APEALFD-RVYTHQSDVWSFGVLLWEIFT 255 >3FXW-A nrPDB Length = 336 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 101/226 (44%), Gaps = 40/226 (17%) Query: 116 RDVYIVQDLMET-DLYKLLKS---QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSN 171 R + I+ + ME +L+ ++ Q + + I ++++HS N+ HRD+KP N Sbjct: 99 RCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPEN 158 Query: 172 LLINTT---CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDI 228 LL + LK+ DFG A+ T T Y Y APE+ L + Y KS D+ Sbjct: 159 LLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPY-----YVAPEV-LGPEKYDKSCDM 212 Query: 229 WSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ--SLPS 286 WS+G I+ +L P F G SP MK R L P+ Sbjct: 213 WSLGVIMYILLCGFPPFYSN---------TGQAISP---------GMKRRIRLGQYGFPN 254 Query: 287 KTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 W+++ D+K L L +L +P +R+T+ + + HP++ Q Sbjct: 255 P---EWSEV--SEDAKQLIRL--LLKTDPTERLTITQFMNHPWINQ 293 >1U54-B nrPDB Length = 291 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 98/204 (48%), Gaps = 15/204 (7%) Query: 45 LQYIGEGAYGMVSSA-YD--HVRKTRVAIKKISP--FEHQTYCQRTLREIQILLRFRHEN 99 L+ +G+G++G+V +D + VA+K + P +RE+ + H N Sbjct: 23 LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRN 82 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ-QLSNDHICYFLYQILRGLKYIH 158 +I + ++ ++ + ++ + L++ +L K Q + + Q+ G+ Y+ Sbjct: 83 LIRLYGVVLTPPMKMVTELAPLGSLLD----RLRKHQGHFLLGTLSRYAVQVAEGMGYLE 138 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEY--VATRWYRAPEIM 216 S +HRDL NLL+ T +KI DFGL R A P++D + E+ V W APE Sbjct: 139 SKRFIHRDLAARNLLLATRDLVKIGDFGLMR-ALPQNDDHYVMQEHRKVPFAWC-APE-S 195 Query: 217 LNSKGYTKSIDIWSVGCILAEMLS 240 L ++ ++ + D W G L EM + Sbjct: 196 LKTRTFSHASDTWMFGVTLWEMFT 219 >5HIE-A nrPDB Length = 302 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 103/218 (47%), Gaps = 17/218 (7%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 Q IG G++G V H VA+K ++P + Q + E+ +L + RH N++ Sbjct: 42 QRIGSGSFGTVYKGKWH---GDVAVKMLTPQQLQAFKN----EVGVLRKTRHVNIL---L 91 Query: 106 ILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYF--LYQILRGLKYIHSANVL 163 + ST + + Q + LY L + + I Q +G+ Y+H+ +++ Sbjct: 92 FMGYSTKPQL--AIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSII 149 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI--MLNSKG 221 HRDLK +N+ ++ +KI DFGLA + F + W APE+ M + Sbjct: 150 HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM-APEVIRMQDKNP 208 Query: 222 YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 259 Y+ D+++ G +L E+++ + + + DQ+ ++G Sbjct: 209 YSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVG 246 >5HLW-A nrPDB Length = 299 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 66/246 (26%), Positives = 115/246 (46%), Gaps = 25/246 (10%) Query: 29 EMVKG-QPFDVGPRYTQLQY---IGEGAYGMVSSAY---DHVRKTRVAIKKISPFEHQTY 81 E+V+ Q +GP + + IG G +G V + +K A+K ++ Sbjct: 5 ELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGE 64 Query: 82 CQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLS-- 139 + L E I+ F H NV+ + I S + ++ + DL ++++ + Sbjct: 65 VSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPL---VVLPYMKHGDLRNFIRNETHNPT 121 Query: 140 -NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPE--- 194 D I + L Q+ +G+KY+ S +HRDL N +++ +K+ DFGLAR + D E Sbjct: 122 VKDLIGFGL-QVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYS 180 Query: 195 -HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLD 252 H+ TG + +W A E + K TKS D+WS G +L E+++ P +P + D Sbjct: 181 VHNKTG---AKLPVKWM-ALESLQTQKFTTKS-DVWSFGVLLWELMTRGAPPYPDVNTFD 235 Query: 253 QLNHIL 258 ++L Sbjct: 236 ITVYLL 241 >3HNG-A nrPDB Length = 360 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 33/105 (31%), Positives = 59/105 (56%), Gaps = 2/105 (1%) Query: 136 QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH 195 + ++ + + + +Q+ RG++++ S +HRDL N+L++ +KICDFGLAR Sbjct: 194 EPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNP 253 Query: 196 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 D+ + +W APE + + K Y+ D+WS G +L E+ S Sbjct: 254 DYVRKGDTRLPLKWM-APESIFD-KIYSTKSDVWSYGVLLWEIFS 296 >4PWN-A nrPDB Length = 274 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 100/209 (47%), Gaps = 31/209 (14%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAI-----KKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 IG G++ V D VA +K++ E Q R E ++L +H N++ Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQ----RFKEEAEMLKGLQHPNIVR 73 Query: 103 IRDILRASTLEAMRDVYIVQDLMETDL-------YKLLKSQQLSNDHICYFLYQILRGLK 155 D ST++ + + +V +LM + +K++K + L + + QIL+GL+ Sbjct: 74 FYDSWE-STVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRS-----WCRQILKGLQ 127 Query: 156 YIHSAN--VLHRDLKPSNLLINT-TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 ++H+ ++HRDLK N+ I T +KI D GLA + F + T + A Sbjct: 128 FLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL----EKRASFAKSVIGTPEFMA 183 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSN 241 PE + + Y +S+D+++ G + EM ++ Sbjct: 184 PE--MYEEKYDESVDVYAFGMCMLEMATS 210 >5GNK-A nrPDB Length = 297 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 47/203 (23%), Positives = 90/203 (44%), Gaps = 9/203 (4%) Query: 42 YTQLQYIGEGAYGMVSSAY----DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 + +++ +G GA+G V K VAIK++ + L E ++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 80 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYI 157 +V + I ST++ + + L++ Y + + ++ + QI +G+ Y+ Sbjct: 81 PHVCRLLGICLTSTVQLIMQLMPFGCLLD---YVREHKDNIGSQYLLNWCVQIAKGMNYL 137 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 ++HRDL N+L+ T +KI DFGLA++ E V +W I+ Sbjct: 138 EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL- 196 Query: 218 NSKGYTKSIDIWSVGCILAEMLS 240 + YT D+WS G + E+++ Sbjct: 197 -HRIYTHQSDVWSYGVTVWELMT 218 >4Y93-A nrPDB Length = 446 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 54/211 (25%), Positives = 99/211 (46%), Gaps = 19/211 (9%) Query: 36 FDVGPR-YTQLQYIGEGAYGMVSSAYDHVR-KTRVAIKKISPFEHQTYCQRTLREIQILL 93 +++ P+ T L+ +G G +G+V Y R + VAIK I E + E ++++ Sbjct: 183 WEIDPKDLTFLKELGTGQFGVVK--YGKWRGQYDVAIKMIK--EGSMSEDEFIEEAKVMM 238 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLKS--QQLSNDHICYFLYQI 150 HE ++ + + R ++I+ + M L L+ + + + Sbjct: 239 NLSHEKLVQLYGVCTKQ-----RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDV 293 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRW 209 ++Y+ S LHRDL N L+N +K+ DFG+ R + D E +T +W Sbjct: 294 CEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDE--YTSSTGSKFPVKW 351 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 +PE+++ SK +KS DIW+ G ++ E+ S Sbjct: 352 -ASPEVLMYSKFSSKS-DIWAFGVLMWEIYS 380 >4HZS-A nrPDB Length = 341 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 98/204 (48%), Gaps = 15/204 (7%) Query: 45 LQYIGEGAYGMVSSA-YD--HVRKTRVAIKKISP--FEHQTYCQRTLREIQILLRFRHEN 99 L+ +G+G++G+V +D + VA+K + P +RE+ + H N Sbjct: 17 LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRN 76 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ-QLSNDHICYFLYQILRGLKYIH 158 +I + ++ ++ + ++ + L++ +L K Q + + Q+ G+ Y+ Sbjct: 77 LIRLYGVVLTPPMKMVTELAPLGSLLD----RLRKHQGHFLLGTLSRYAVQVAEGMGYLE 132 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEY--VATRWYRAPEIM 216 S +HRDL NLL+ T +KI DFGL R A P++D + E+ V W APE Sbjct: 133 SKRFIHRDLAARNLLLATRDLVKIGDFGLMR-ALPQNDDHYVMQEHRKVPFAWC-APE-S 189 Query: 217 LNSKGYTKSIDIWSVGCILAEMLS 240 L ++ ++ + D W G L EM + Sbjct: 190 LKTRTFSHASDTWMFGVTLWEMFT 213 >3LZB-A nrPDB Length = 327 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 47/203 (23%), Positives = 90/203 (44%), Gaps = 9/203 (4%) Query: 42 YTQLQYIGEGAYGMVSSAY----DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 + +++ +G GA+G V K VAIK++ + L E ++ + Sbjct: 17 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 76 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYI 157 +V + I ST++ + + L++ Y + + ++ + QI +G+ Y+ Sbjct: 77 PHVCRLLGICLTSTVQLITQLMPFGCLLD---YVREHKDNIGSQYLLNWCVQIAKGMNYL 133 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 ++HRDL N+L+ T +KI DFGLA++ E V +W I+ Sbjct: 134 EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL- 192 Query: 218 NSKGYTKSIDIWSVGCILAEMLS 240 + YT D+WS G + E+++ Sbjct: 193 -HRIYTHQSDVWSYGVTVWELMT 214 >3C1X-A nrPDB Length = 373 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 57/236 (24%), Positives = 106/236 (44%), Gaps = 24/236 (10%) Query: 38 VGPRYTQLQY---IGEGAYGMVSSAY---DHVRKTRVAIKKISPFEHQTYCQRTLREIQI 91 +GP + + IG G +G V + +K A+K ++ + L E I Sbjct: 84 IGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGII 143 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLS---NDHICYFLY 148 + F H NV+ + I S + ++ + DL ++++ + D I + L Sbjct: 144 MKDFSHPNVLSLLGICLRSEGSPL---VVLPYMKHGDLRNFIRNETHNPTVKDLIGFGL- 199 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA-----DPEHDHTGFLTE 203 Q+ +G+K++ S +HRDL N +++ +K+ DFGLAR D H+ TG Sbjct: 200 QVAKGMKFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTG---A 256 Query: 204 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHIL 258 + +W L ++ +T D+WS G +L E+++ P +P + D ++L Sbjct: 257 KLPVKWMALES--LQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLL 310 >6NPU-A nrPDB Length = 298 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 51/197 (25%), Positives = 88/197 (44%), Gaps = 14/197 (7%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G G YG V VA+K + E + L+E ++ +H N++ +L Sbjct: 34 LGGGQYGEVYEGVWKKYSLTVAVKTLK--EDTMEVEEFLKEAAVMKEIKHPNLV---QLL 88 Query: 108 RASTLEAMRDVYIVQDLME----TDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 T E YI+ + M D + Q+++ + Y QI ++Y+ N + Sbjct: 89 GVCTREP--PFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFI 146 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 223 HRDL N L+ +K+ DFGL+R+ + +T +W APE + +K Sbjct: 147 HRDLAARNCLVGENHLVKVADFGLSRLMTGD-TYTAHAGAKFPIKW-TAPESLAYNKFSI 204 Query: 224 KSIDIWSVGCILAEMLS 240 KS D+W+ G +L E+ + Sbjct: 205 KS-DVWAFGVLLWEIAT 220 >3MDY-A nrPDB Length = 337 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 73/257 (28%), Positives = 113/257 (43%), Gaps = 27/257 (10%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 + + ++ IG+G YG V R +VA+K E ++ + T EI + RH Sbjct: 35 IAKQIQMVKQIGKGRYGEVWMG--KWRGEKVAVKVFFTTEEASWFRET--EIYQTVLMRH 90 Query: 98 ENVIGI--RDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDHICYFLYQILRGL 154 EN++G DI + + Y++ D E LY LKS L + Y + GL Sbjct: 91 ENILGFIAADIKGTGSWTQL---YLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGL 147 Query: 155 KYIHSA--------NVLHRDLKPSNLLINTTCDLKICDFGLAR--IADPEHDHTGFLTEY 204 ++H+ + HRDLK N+L+ I D GLA I+D T Sbjct: 148 CHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTR- 206 Query: 205 VATRWYRAPEIM---LNSKGYTKSI--DIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 259 V T+ Y PE++ LN + I D++S G IL E ++ R + G QL + Sbjct: 207 VGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWE-VARRCVSGGIVEEYQLPYHDL 265 Query: 260 ILGSPSQEDLNCIINMK 276 + PS ED+ I+ +K Sbjct: 266 VPSDPSYEDMREIVCIK 282 >5B2L-A nrPDB Length = 324 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 61/226 (26%), Positives = 103/226 (45%), Gaps = 26/226 (11%) Query: 39 GPRY----TQLQYIGEGAYGMVSSAYD-HVRKTR--VAIKKISPFEHQTYCQRTLREIQI 91 G RY L+ +GE G + RKT +A+K++ ++ +R L ++ + Sbjct: 9 GQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDV 68 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ--LSNDHICYFLYQ 149 +L+ I + T DV+I +LM T KL K Q + + Sbjct: 69 VLKSHDCPYI----VQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVA 124 Query: 150 ILRGLKYIHSAN-VLHRDLKPSNLLINTTCDLKICDFGLA-RIADPEHDHTGFLTEYVAT 207 I++ L Y+ + V+HRD+KPSN+L++ +K+CDFG++ R+ D + T Sbjct: 125 IVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAK-----TRSAGC 179 Query: 208 RWYRAPEIM----LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKH 249 Y APE + Y D+WS+G L E+ + + FP K+ Sbjct: 180 AAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQ--FPYKN 223 >4XEY-B nrPDB Length = 408 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/231 (24%), Positives = 100/231 (43%), Gaps = 18/231 (7%) Query: 14 PRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI 73 P+R + GV + + + D+ T +G G YG V VA+K + Sbjct: 103 PKRNKPTVYGVSPNYDKWEMERTDI----TMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL 158 Query: 74 SPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME----TDL 129 E + L+E ++ +H N++ +L T E YI+ + M D Sbjct: 159 K--EDTMEVEEFLKEAAVMKEIKHPNLV---QLLGVCTREP--PFYIITEFMTYGNLLDY 211 Query: 130 YKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR 189 + Q+++ + Y QI ++Y+ N +HRDL N L+ +K+ DFGL+R Sbjct: 212 LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 271 Query: 190 IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + + +T +W APE + +K KS D+W+ G +L E+ + Sbjct: 272 LMTGD-TYTAHAGAKFPIKW-TAPESLAYNKFSIKS-DVWAFGVLLWEIAT 319 >5TUR-A nrPDB Length = 404 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 60/231 (25%), Positives = 102/231 (44%), Gaps = 35/231 (15%) Query: 24 VPG-EVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIK-----KISPFE 77 PG E E ++ Q + VGP +G G +G V S VAIK +IS + Sbjct: 117 APGKEKEPLESQ-YQVGP------LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWG 169 Query: 78 HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI--------VQDLMETDL 129 R E+ +L + G ++R D ++ VQDL + Sbjct: 170 ELPNGTRVPMEVVLLKKVSS----GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 225 Query: 130 YKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN-TTCDLKICDFGLA 188 + ++L+ F +Q+L +++ H+ VLHRD+K N+LI+ +LK+ DFG Sbjct: 226 ERGALQEELARS----FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSG 281 Query: 189 RIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239 + T++ TR Y PE + + + +S +WS+G +L +M+ Sbjct: 282 ALLK-----DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV 327 >6GVJ-A nrPDB Length = 429 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 82/317 (25%), Positives = 133/317 (41%), Gaps = 54/317 (17%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-EIQILLRFRH 97 G Y+ L+ IG G V + +K AIK ++ E + R EI L + + Sbjct: 143 GRIYSILKQIGSGGSSKVFQVLNE-KKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 201 Query: 98 ENVIGIRDILRASTLEAMRD-VYIVQDLMETDLYKLLKSQQLSN--DHICYFLYQILRGL 154 + I+R E +Y+V + DL LK ++ + + Y+ +L + Sbjct: 202 HS----DKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYW-KNMLEAV 256 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVATRWYRAP 213 IH ++H DLKP+N LI LK+ DFG+A P D T + + V T Y P Sbjct: 257 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQP--DTTSVVKDSQVGTVNYMPP 313 Query: 214 EIMLNSKGYTKS----------IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS 263 E + + ++ D+WS+GCIL M + P + ++Q++ + I+ Sbjct: 314 EAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGK--TPFQQIINQISKLHAII-- 369 Query: 264 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKAL-DLLDRMLTFNPNKRITVE 322 D N I FP K L D+L L +P +RI++ Sbjct: 370 ----DPNHEIE---------------------FPDIPEKDLQDVLKCCLKRDPKQRISIP 404 Query: 323 EALAHPYLEQYYDPTDE 339 E LAHPY++ P ++ Sbjct: 405 ELLAHPYVQIQTHPVNQ 421 >3HMP-A nrPDB Length = 342 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 81/317 (25%), Positives = 133/317 (41%), Gaps = 54/317 (17%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-EIQILLRFRH 97 G Y+ L+ IG G V + +K AIK ++ E + R EI L + + Sbjct: 55 GRIYSILKQIGSGGSSKVFQVLNE-KKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 113 Query: 98 ENVIGIRDILRASTLEAMRD-VYIVQDLMETDLYKLLKSQQLSN--DHICYFLYQILRGL 154 + I+R E +Y+V + DL LK ++ + + Y+ +L + Sbjct: 114 HS----DKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYW-KNMLEAV 168 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVATRWYRAP 213 IH ++H DLKP+N LI LK+ DFG+A P D T + + V T Y P Sbjct: 169 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQP--DTTSVVKDSQVGTVNYMPP 225 Query: 214 EIMLNSKGYTKS----------IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS 263 E + + ++ D+WS+GCIL M + P + ++Q++ + I+ Sbjct: 226 EAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQISKLHAII-D 282 Query: 264 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKAL-DLLDRMLTFNPNKRITVE 322 P+ E FP K L D+L L +P +RI++ Sbjct: 283 PNHE--------------------------IEFPDIPEKDLQDVLKCCLKRDPKQRISIP 316 Query: 323 EALAHPYLEQYYDPTDE 339 E LAHPY++ P ++ Sbjct: 317 ELLAHPYVQIQTHPVNQ 333 >4RT7-A nrPDB Length = 415 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 34/100 (34%), Positives = 55/100 (55%), Gaps = 3/100 (3%) Query: 141 DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGF 200 D +C F YQ+ +G++++ + +HRDL N+L+ +KICDFGLAR + ++ Sbjct: 244 DLLC-FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVR 302 Query: 201 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + +W APE + YT D+WS G +L E+ S Sbjct: 303 GNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFS 340 >2XYN-A nrPDB Length = 292 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 51/197 (25%), Positives = 88/197 (44%), Gaps = 14/197 (7%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G G YG V VA+K + E + L+E ++ +H N++ +L Sbjct: 40 LGGGQYGEVYVGVWKKYSLTVAVKTLK--EDTMEVEEFLKEAAVMKEIKHPNLV---QLL 94 Query: 108 RASTLEAMRDVYIVQDLME----TDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 TLE YIV + M D + ++++ + Y QI ++Y+ N + Sbjct: 95 GVCTLEP--PFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI 152 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 223 HRDL N L+ +K+ DFGL+R+ + +T +W APE + + Sbjct: 153 HRDLAARNCLVGENHVVKVADFGLSRLMTGD-TYTAHAGAKFPIKW-TAPESLAYNTFSI 210 Query: 224 KSIDIWSVGCILAEMLS 240 KS D+W+ G +L E+ + Sbjct: 211 KS-DVWAFGVLLWEIAT 226 >2FO0-A nrPDB Length = 495 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 50/197 (25%), Positives = 88/197 (44%), Gaps = 14/197 (7%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G G YG V VA+K + E + L+E ++ +H N++ +L Sbjct: 225 LGGGQYGEVYEGVWKKYSLTVAVKTLK--EDTMEVEEFLKEAAVMKEIKHPNLV---QLL 279 Query: 108 RASTLEAMRDVYIVQDLME----TDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 T E YI+ + M D + Q+++ + Y QI ++Y+ N + Sbjct: 280 GVCTREP--PFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFI 337 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 223 HR+L N L+ +K+ DFGL+R+ + +T +W APE + +K Sbjct: 338 HRNLAARNCLVGENHLVKVADFGLSRLMTGD-TYTAHAGAKFPIKW-TAPESLAYNKFSI 395 Query: 224 KSIDIWSVGCILAEMLS 240 KS D+W+ G +L E+ + Sbjct: 396 KS-DVWAFGVLLWEIAT 411 >6BSD-A nrPDB Length = 876 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 71/273 (26%), Positives = 114/273 (41%), Gaps = 53/273 (19%) Query: 7 QGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQY---IGEGAYGMV-----SS 58 QG GG + PG G+ G P PR ++L++ +GEG +G V S Sbjct: 541 QGVTGGNTYAVPALPPGAVGD-----GPPRVDFPR-SRLRFKEKLGEGQFGEVHLCEVDS 594 Query: 59 AYD--------HVRKTR---VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 D +VRK VA+K + P + L+E++I+ R + N+I + + Sbjct: 595 PQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVC 654 Query: 108 RASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDH--------------------ICYF 146 M + D ME DL + L + QL + + + Sbjct: 655 VQDDPLCM-----ITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHV 709 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 QI G++Y+ + N +HRDL N L+ +KI DFG++R + + Sbjct: 710 AAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLP 769 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239 RW A E +L K +T + D+W+ G L E+L Sbjct: 770 IRWM-AWECILMGK-FTTASDVWAFGVTLWEVL 800 >2OGV-A nrPDB Length = 317 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 99/212 (46%), Gaps = 27/212 (12%) Query: 48 IGEGAYGMVSSAY-------DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF-RHEN 99 +G GA+G V A D V K VA+K + H + + E++I+ +HEN Sbjct: 46 LGAGAFGKVVEATAFGLGKEDAVLK--VAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 103 Query: 100 VIGIRDILRAST----LEAMRDVYIVQDLM-------ETDLYKLLKSQQLSNDHICYFLY 148 ++ ++L A T + + + DL+ E DL K + L + +F Sbjct: 104 IV---NLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKE-DGRPLELRDLLHFSS 159 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 Q+ +G+ ++ S N +HRD+ N+L+ KI DFGLAR + ++ + + Sbjct: 160 QVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVK 219 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 W APE + + YT D+WS G +L E+ S Sbjct: 220 W-MAPESIFDCV-YTVQSDVWSYGILLWEIFS 249 >6FEX-A nrPDB Length = 321 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 96/223 (43%), Gaps = 38/223 (17%) Query: 48 IGEGAYGMV-----SSAYD--------HVRKTR---VAIKKISPFEHQTYCQRTLREIQI 91 +GEG +G V S D +VRK VA+K + P + L+E++I Sbjct: 24 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKI 83 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDH-------- 142 + R + N+I + + M + D ME DL + L + QL + Sbjct: 84 MSRLKDPNIIRLLGVCVQDDPLCM-----ITDYMENGDLNQFLSAHQLEDKAAEGAPGDP 138 Query: 143 ------ICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 + + QI G++Y+ + N +HRDL N L+ +KI DFG++R Sbjct: 139 TISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDY 198 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239 + + RW A E +L K +T + D+W+ G L E+L Sbjct: 199 YRVQGRAVLPIRWM-AWECILMGK-FTTASDVWAFGVTLWEVL 239 >5AP3-A nrPDB Length = 313 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 81/317 (25%), Positives = 133/317 (41%), Gaps = 54/317 (17%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-EIQILLRFRH 97 G Y+ L+ IG G V + +K AIK ++ E + R EI L + + Sbjct: 27 GRIYSILKQIGSGGSSKVFQVLNE-KKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 85 Query: 98 ENVIGIRDILRASTLEAMRD-VYIVQDLMETDLYKLLKSQQLSN--DHICYFLYQILRGL 154 + I+R E +Y+V + DL LK ++ + + Y+ +L + Sbjct: 86 HS----DKIIRLYDYEITDQYIYMVMECGNIDLNGWLKKKKSIDPWERKSYW-KNMLEAV 140 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVATRWYRAP 213 IH ++H DLKP+N LI LK+ DFG+A P D T + + V T Y P Sbjct: 141 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQP--DTTSVVKDSQVGTVNYMPP 197 Query: 214 EIMLNSKGYTKS----------IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS 263 E + + ++ D+WS+GCIL M + P + ++Q++ + I+ Sbjct: 198 EAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQISKLHAII-D 254 Query: 264 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKAL-DLLDRMLTFNPNKRITVE 322 P+ E FP K L D+L L +P +RI++ Sbjct: 255 PNHE--------------------------IEFPDIPEKDLQDVLKCCLKRDPKQRISIP 288 Query: 323 EALAHPYLEQYYDPTDE 339 E LAHPY++ P ++ Sbjct: 289 ELLAHPYVQIQTHPVNQ 305 >3BGP-A nrPDB Length = 333 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 102/230 (44%), Gaps = 35/230 (15%) Query: 25 PG-EVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIK-----KISPFEH 78 PG E E ++ Q + VGP +G G +G V S VAIK +IS + Sbjct: 47 PGKEKEPLESQ-YQVGP------LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGE 99 Query: 79 QTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI--------VQDLMETDLY 130 R E+ +L + G ++R D ++ VQDL + Sbjct: 100 LPNGTRVPMEVVLLKKVSS----GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE 155 Query: 131 KLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN-TTCDLKICDFGLAR 189 + ++L+ F +Q+L +++ H+ VLHRD+K N+LI+ +LK+ DFG Sbjct: 156 RGALQEELARS----FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA 211 Query: 190 IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239 + T++ TR Y PE + + + +S +WS+G +L +M+ Sbjct: 212 LLK-----DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV 256 >4RC3-A nrPDB Length = 289 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 95/218 (43%), Gaps = 33/218 (15%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIK-----KISPFEHQTYCQRTLREIQ 90 + VGP +G G +G V S VAIK +IS + R E+ Sbjct: 14 YQVGP------LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 67 Query: 91 ILLRFRHENVIGIRDILRASTLEAMRDVYI--------VQDLMETDLYKLLKSQQLSNDH 142 +L + G ++R D ++ VQDL + + ++L+ Sbjct: 68 LLKKVSS----GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS- 122 Query: 143 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN-TTCDLKICDFGLARIADPEHDHTGFL 201 F +Q+L +++ H+ VLHRD+K N+LI+ +LK+ DFG + Sbjct: 123 ---FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-----DTVY 174 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239 T++ TR Y PE + + + +S +WS+G +L +M+ Sbjct: 175 TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV 212 >3M42-A nrPDB Length = 299 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 75/324 (23%), Positives = 135/324 (41%), Gaps = 74/324 (22%) Query: 21 GPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQT 80 GP V +++ K D +Q+ +G G G V ++ + + A+K + Sbjct: 1 GPHVKSGLQIKKNAIIDDYKVTSQV--LGLGINGKVLQIFNKRTQEKFALKMLQD----- 53 Query: 81 YCQRTLREIQILLRFRH-ENVIGIRDILRASTLEAMRDVYIVQDLMET----DLYKLLKS 135 C + RE+++ R +++ I D+ L A R ++ +ME +L+ ++ Sbjct: 54 -CPKARREVELHWRASQCPHIVRIVDVY--ENLYAGRKCLLI--VMECLDGGELFSRIQD 108 Query: 136 ---QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT---TCDLKICDFGLAR 189 Q + + I ++Y+HS N+ HRD+KP NLL + LK+ DFG A+ Sbjct: 109 RGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK 168 Query: 190 IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKH 249 + TG + Y KS D+WS+G I+ +L P F H Sbjct: 169 ------ETTG--------------------EKYDKSCDMWSLGVIMYILLCGYPPFYSNH 202 Query: 250 YLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDR 309 G+ SP + + R P+ W+++ S+ + +L R Sbjct: 203 ---------GLAISPG-------MKTRIRMGQYEFPNP---EWSEV-----SEEVKMLIR 238 Query: 310 -MLTFNPNKRITVEEALAHPYLEQ 332 +L P +R+T+ E + HP++ Q Sbjct: 239 NLLKTEPTQRMTITEFMNHPWIMQ 262 >5IKW-A nrPDB Length = 310 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 56/220 (25%), Positives = 98/220 (44%), Gaps = 21/220 (9%) Query: 36 FDVGPRYTQLQ-YIGEGAYGMVSSAYDHVRKTRVAIKK--ISPFEHQTYCQRTLREIQIL 92 F VG L+ + EG + V H R A+K+ ++ C+R EI I+ Sbjct: 9 FAVGRHQVTLEESLAEGGFSTVFLVRTH-GGIRCALKRMYVNNMPDLNVCKR---EITIM 64 Query: 93 LRFR-HENVIGIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQ--LSNDHICYFL 147 H+N++G D S + + +V I+ + + ++ K Q + + Sbjct: 65 KELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIF 124 Query: 148 YQILRGLKYIHSAN--VLHRDLKPSNLLINTTCDLKICDFGLA--RIADPEHDHTGFLTE 203 + +H ++HRDLK N+L+N + +CDFG A + +P+ D + E Sbjct: 125 CDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEE 184 Query: 204 YV---ATRWYRAPEI--MLNSKGYTKSIDIWSVGCILAEM 238 + T YRAPE+ + K T DIW++GC+L ++ Sbjct: 185 EIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKL 224 >4XLV-A nrPDB Length = 328 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 58/220 (26%), Positives = 106/220 (48%), Gaps = 30/220 (13%) Query: 41 RYTQLQYIGEGAYGMV--SSAYDHVR---KTRVAIKKISPFEHQTYCQRT--LREIQILL 93 + T L+ +G+G++GMV +A D ++ +TRVA+K ++ E + +R L E ++ Sbjct: 40 KITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN--ESASLRERIEFLNEASVMK 97 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQLSNDH---------- 142 F +V+ + ++ + +V +LM DL L+S + ++ Sbjct: 98 GFTCHHVVRLLGVVSKG-----QPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQ 152 Query: 143 -ICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGF 200 + +I G+ Y+++ +HRDL N ++ +KI DFG+ R I + ++ G Sbjct: 153 EMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGG 212 Query: 201 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + RW APE L +T S D+WS G +L E+ S Sbjct: 213 -KGLLPVRWM-APE-SLKDGVFTTSSDMWSFGVVLWEITS 249 >5AMN-A nrPDB Length = 299 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 91/209 (43%), Gaps = 22/209 (10%) Query: 48 IGEGAYGMVSSAYDHVRKTR-----VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 +GEG +G V A K R VA+K + + + L E +L + H +VI Sbjct: 31 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIK 90 Query: 103 IRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-----------LSNDHICYFLYQIL 151 L + + + IV+ L L+ + L+ + F +QI Sbjct: 91 ----LYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQIS 146 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 +G++Y+ ++HRDL N+L+ +KI DFGL+R E + + +W Sbjct: 147 QGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM- 205 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLS 240 A E + + YT D+WS G +L E+++ Sbjct: 206 AIESLFDHI-YTTQSDVWSFGVLLWEIVT 233 >4Y12-A nrPDB Length = 375 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 50/166 (30%), Positives = 83/166 (50%), Gaps = 13/166 (7%) Query: 90 QILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQ 149 Q L H +++ I + + + YIV + + K K Q+L +L + Sbjct: 170 QFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLE 229 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFG-LARIADPEHDHTGFLTEYVATR 208 IL L Y+HS +++ DLKP N+++ T LK+ D G ++RI + G+L T Sbjct: 230 ILPALSYLHSIGLVYNDLKPENIML-TEEQLKLIDLGAVSRI-----NSFGYL---YGTP 280 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 ++APEI+ G T + DI++VG LA + + P G+ Y+D L Sbjct: 281 GFQAPEIV--RTGPTVATDIYTVGRTLAALTLDLPTRNGR-YVDGL 323 >4FL3-A nrPDB Length = 635 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 60/110 (54%), Gaps = 3/110 (2%) Query: 132 LLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA 191 L +++ + + +I ++Q+ G+KY+ +N +HRDL N+L+ T KI DFGL++ Sbjct: 460 LQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 519 Query: 192 DPEHDHTGFLTE-YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + ++ T +WY APE +N ++ D+WS G ++ E S Sbjct: 520 RADENYYKAQTHGKWPVKWY-APEC-INYYKFSSKSDVWSFGVLMWEAFS 567 >4AT3-A nrPDB Length = 299 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 96/213 (45%), Gaps = 28/213 (13%) Query: 48 IGEGAYGMV--SSAYD---HVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 +GEGA+G V + Y+ K VA+K + + RE ++L +HE+++ Sbjct: 21 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNAR-KDFHREAELLTNLQHEHIVK 79 Query: 103 IRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ--------------QLSNDHICYFLY 148 + +E + + + + DL K L++ +L+ + + Sbjct: 80 FYGV----CVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQ 135 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVAT 207 QI G+ Y+ S + +HRDL N L+ +KI DFG++R + ++ G T + Sbjct: 136 QIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHT-MLPI 194 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 RW IM + +T D+WS+G +L E+ + Sbjct: 195 RWMPPESIMY--RKFTTESDVWSLGVVLWEIFT 225 >2J0K-A nrPDB Length = 656 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/200 (25%), Positives = 96/200 (48%), Gaps = 19/200 (9%) Query: 48 IGEGAYGMVSSAYDHVRKT---RVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 IGEG +G V + VAIK + ++ L+E + +F H +++ + Sbjct: 398 IGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI 457 Query: 105 DILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSND--HICYFLYQILRGLKYIHSAN 161 ++ + V+I+ +L +L L+ ++ S D + + YQ+ L Y+ S Sbjct: 458 GVITENP------VWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYLESKR 511 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE--YVATRWYRAPEIMLNS 219 +HRD+ N+L++ T +K+ DFGL+R + D T + + +W APE +N Sbjct: 512 FVHRDIAARNVLVSATDCVKLGDFGLSRYME---DSTYYKASKGKLPIKWM-APE-SINF 566 Query: 220 KGYTKSIDIWSVGCILAEML 239 + +T + D+W G + E+L Sbjct: 567 RRFTSASDVWMFGVCMWEIL 586 >4OTD-A nrPDB Length = 341 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/197 (25%), Positives = 92/197 (46%), Gaps = 37/197 (18%) Query: 128 DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGL 187 DL + S S ++ ++ GL+++H +++RDLK NLL++T +KI DFGL Sbjct: 101 DLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGL 160 Query: 188 ARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 247 + D T + + T + APE++ ++ YT+++D W +G +L EML FPG Sbjct: 161 CKEGMGYGDRT---STFCGTPEFLAPEVLTDTS-YTRAVDWWGLGVLLYEMLVGESPFPG 216 Query: 248 KHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKS-DSKALDL 306 +E + I+N + R +P+ ++A+ + Sbjct: 217 DD---------------EEEVFDSIVNDEVR-----------------YPRFLSAEAIGI 244 Query: 307 LDRMLTFNPNKRITVEE 323 + R+L NP +R+ E Sbjct: 245 MRRLLRRNPERRLGSSE 261 >2ZMD-A nrPDB Length = 390 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 80/317 (25%), Positives = 132/317 (41%), Gaps = 54/317 (17%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-EIQILLRFRH 97 G Y+ L+ IG G V + +K AIK ++ E + R EI L + + Sbjct: 55 GRIYSILKQIGSGGSSKVFQVLNE-KKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 113 Query: 98 ENVIGIRDILRASTLEAMRD-VYIVQDLMETDLYKLLKSQQLSN--DHICYFLYQILRGL 154 + I+R E +Y+V + DL LK ++ + + Y+ +L + Sbjct: 114 HS----DKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYW-KNMLEAV 168 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVATRWYRAP 213 IH ++H DLKP+N LI LK+ DFG+A P D T + + V Y P Sbjct: 169 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQP--DTTSVVKDSQVGAVNYMPP 225 Query: 214 EIMLNSKGYTKS----------IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS 263 E + + ++ D+WS+GCIL M + P + ++Q++ + I+ Sbjct: 226 EAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQISKLHAII-D 282 Query: 264 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKAL-DLLDRMLTFNPNKRITVE 322 P+ E FP K L D+L L +P +RI++ Sbjct: 283 PNHE--------------------------IEFPDIPEKDLQDVLKCCLKRDPKQRISIP 316 Query: 323 EALAHPYLEQYYDPTDE 339 E LAHPY++ P ++ Sbjct: 317 ELLAHPYVQIQTHPVNQ 333 >5C26-A nrPDB Length = 299 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 60/110 (54%), Gaps = 3/110 (2%) Query: 132 LLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA 191 L +++ + + +I ++Q+ G+KY+ +N +HRDL N+L+ T KI DFGL++ Sbjct: 118 LQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 177 Query: 192 DPEHDHTGFLTE-YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + ++ T +WY APE +N ++ D+WS G ++ E S Sbjct: 178 RADENYYKAQTHGKWPVKWY-APEC-INYYKFSSKSDVWSFGVLMWEAFS 225 >4CRS-A nrPDB Length = 341 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 94/209 (44%), Gaps = 42/209 (20%) Query: 128 DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGL 187 DL + + S ++ ++ GL+Y+H +++RDLK NLL++T +KI DFGL Sbjct: 101 DLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGL 160 Query: 188 ARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 247 + D T + + T + APE+ L YT+++D W +G ++ EML FP Sbjct: 161 CKEGMGYGDRT---STFCGTPEFLAPEV-LTETSYTRAVDWWGLGVLIYEMLVGESPFP- 215 Query: 248 KHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKS-DSKALDL 306 G +E + I+N + R +P+ ++A+ + Sbjct: 216 --------------GDDEEEVFDSIVNDEVR-----------------YPRFLSTEAISI 244 Query: 307 LDRMLTFNPNKRITVEEALA-----HPYL 330 + R+L NP +R+ E A HP+ Sbjct: 245 MRRLLRRNPERRLGASEKDAEDVKKHPFF 273 >2BUJ-A nrPDB Length = 317 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 14/211 (6%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 Y +Q +GEG + V A+K+I E Q + RE + F H N++ Sbjct: 31 YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDR-EEAQREADMHRLFNHPNIL 89 Query: 102 GIRDIL---RASTLEAMRDV-YIVQDLMETDLYKLL-KSQQLSNDHICYFLYQILRGLKY 156 + R + EA + + + + ++ +L K L+ D I + L I RGL+ Sbjct: 90 RLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEA 149 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFG---LARIADPEHDHTGFLTEYVATRW---Y 210 IH+ HRDLKP+N+L+ + D G A I L ++ A R Y Sbjct: 150 IHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISY 209 Query: 211 RAPEIMLNSKGYT--KSIDIWSVGCILAEML 239 RAPE+ + D+WS+GC+L M+ Sbjct: 210 RAPELFSVQSHCVIDERTDVWSLGCVLYAMM 240 >4R7H-A nrPDB Length = 343 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 55/223 (24%), Positives = 100/223 (44%), Gaps = 36/223 (16%) Query: 48 IGEGAYGMV--SSAYDHVRKT---RVAIKKISPFEHQTYCQRTLREIQILLRF-RHENVI 101 +G GA+G V ++A+ ++ +VA+K + H + + E++I+ +HEN++ Sbjct: 58 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 117 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ------------------------ 137 ++L A T + I + DL L+ + Sbjct: 118 ---NLLGACT-HGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRP 173 Query: 138 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDH 197 L + +F Q+ +G+ ++ S N +HRD+ N+L+ KI DFGLAR + ++ Sbjct: 174 LELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNY 233 Query: 198 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + +W APE + +S YT D+WS G +L E+ S Sbjct: 234 IVKGNARLPVKWM-APESIFDSV-YTVQSDVWSYGILLWEIFS 274 >1FVR-A nrPDB Length = 327 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 93/209 (44%), Gaps = 21/209 (10%) Query: 48 IGEGAYGMVSSAYDHVRKTRV--AIKKISPFEHQTYCQRTLREIQILLRF-RHENVIGI- 103 IGEG +G V A R+ AIK++ + + + E+++L + H N+I + Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 92 Query: 104 -----RDILRASTLEA----MRDVYIVQDLMETD-LYKLLKS--QQLSNDHICYFLYQIL 151 R L + A + D ++ETD + + S LS+ + +F + Sbjct: 93 GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVA 152 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 RG+ Y+ +HRDL N+L+ KI DFGL+R + T + RW Sbjct: 153 RGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKT---MGRLPVRWMA 209 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLS 240 LN YT + D+WS G +L E++S Sbjct: 210 IES--LNYSVYTTNSDVWSYGVLLWEIVS 236 >5J0A-A nrPDB Length = 300 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 55/183 (30%), Positives = 86/183 (46%), Gaps = 13/183 (7%) Query: 69 AIKKISPF--EH--QTYCQRTLREIQILLRFRHENVIGIRDILRA---STLEAMR--DVY 119 A+KKI+P +H Y +R + E +IL H N++G R A S AM Sbjct: 41 AVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEK 100 Query: 120 IVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH-SANVLHRDLKPSNLLINTTC 178 + DL+E + YK I + RGLKY+H +LH D+K SN++I Sbjct: 101 SLNDLIE-ERYKA-SQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDF 158 Query: 179 D-LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE 237 + +KICD G++ D + T Y+ T ++ E + + T DI++ G L E Sbjct: 159 ETIKICDVGVSLPLDENMEVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWE 218 Query: 238 MLS 240 M++ Sbjct: 219 MMT 221 >2PZI-A nrPDB Length = 681 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 50/166 (30%), Positives = 83/166 (50%), Gaps = 13/166 (7%) Query: 90 QILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQ 149 Q L H +++ I + + + YIV + + K K Q+L +L + Sbjct: 131 QFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLE 190 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFG-LARIADPEHDHTGFLTEYVATR 208 IL L Y+HS +++ DLKP N+++ T LK+ D G ++RI + G+L T Sbjct: 191 ILPALSYLHSIGLVYNDLKPENIML-TEEQLKLIDLGAVSRI-----NSFGYL---YGTP 241 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 ++APEI+ G T + DI++VG LA + + P G+ Y+D L Sbjct: 242 GFQAPEIV--RTGPTVATDIYTVGRTLAALTLDLPTRNGR-YVDGL 284 >4TPT-A nrPDB Length = 303 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 50/214 (23%), Positives = 88/214 (41%), Gaps = 24/214 (11%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT-LREIQILLRFRHENVIGIR 104 + +G+G +G + +K++ + +T Q+T L E++++ H NV+ Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEET--QKTFLTEVKVMRSLDHPNVLKFI 63 Query: 105 DILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLH 164 +L + YI ++ L + F I G+ Y+HS ++H Sbjct: 64 GVLYKDKKLNLLTEYIEGGTLKDFLRSM---DPFPWQQKVRFAKGIASGMAYLHSMCIIH 120 Query: 165 RDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR---------------- 208 RDL N LI + + DFGL+R+ E R Sbjct: 121 RDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 180 Query: 209 -WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN 241 ++ APE MLN K Y +++DI+S G +L E++ Sbjct: 181 PYWMAPE-MLNGKSYDETVDIFSFGIVLCEIIGQ 213 >4LRM-A nrPDB Length = 334 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 47/206 (22%), Positives = 90/206 (43%), Gaps = 12/206 (5%) Query: 42 YTQLQYIGEGAYGMVSSAY----DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 + +++ +G GA+G V K VAIK++ + L E ++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 80 Query: 98 E---NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGL 154 +V + I ST++ + + L++ Y + + ++ + QI +G+ Sbjct: 81 PGNPHVCRLLGICLTSTVQLITQLMPFGCLLD---YVREHKDNIGSQYLLNWCVQIAKGM 137 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 Y+ ++HRDL N+L+ T +KI DFGLA++ E V +W Sbjct: 138 NYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALES 197 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLS 240 I+ + YT D+WS G + E+++ Sbjct: 198 IL--HRIYTHQSDVWSYGVTVWELMT 221 >3SOC-A nrPDB Length = 322 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 67/261 (25%), Positives = 114/261 (43%), Gaps = 32/261 (12%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG-I 103 L+ G +G V A + VA+K I P + + Q E+ L +HEN++ I Sbjct: 29 LEVKARGRFGCVWKA--QLLNEYVAVK-IFPIQDKQSWQNEY-EVYSLPGMKHENILQFI 84 Query: 104 RDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDHICYFLYQILRGLKYIH---- 158 R ++++ D++++ E L LK+ +S + +C+ + RGL Y+H Sbjct: 85 GAEKRGTSVDV--DLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIP 142 Query: 159 ------SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 + HRD+K N+L+ I DFGLA + G V TR Y A Sbjct: 143 GLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLA-LKFEAGKSAGDTHGQVGTRRYMA 201 Query: 213 PEIMLNSKGYTKS----IDIWSVGCILAEMLSNRPIFPG--KHYLDQLNHILGILGSPSQ 266 PE++ + + + ID++++G +L E+ S G Y+ +G PS Sbjct: 202 PEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG--QHPSL 259 Query: 267 EDLNCIINMKA-----RNYLQ 282 ED+ ++ K R+Y Q Sbjct: 260 EDMQEVVVHKKKRPVLRDYWQ 280 >6BFN-A nrPDB Length = 342 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 52/206 (25%), Positives = 90/206 (43%), Gaps = 13/206 (6%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKI---SPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 IGEG +G V A +R T A+K++ + E Q L E++ L RFRH N++ Sbjct: 30 IGEGGFGCVYRAV--MRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFA 87 Query: 105 DILRASTLEAMRDVYIVQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLKYIH--SAN 161 + + ++ +E L+ + LS L R ++++H S + Sbjct: 88 GYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPS 147 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLARI-----ADPEHDHTGFLTEYVATRWYRAPEIM 216 ++H D+K SN+L++ K+ DFGLAR + P T+ V PE Sbjct: 148 LIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEY 207 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNR 242 + + D +S G ++ E L+ + Sbjct: 208 IKTGRLAVDTDTFSFGVVVLETLAGQ 233 >2QLU-A nrPDB Length = 314 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 99/213 (46%), Gaps = 24/213 (11%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG-I 103 L+ G +G V A + VA+K I P + + Q + REI +HEN++ I Sbjct: 20 LEIKARGRFGCVWKA--QLMNDFVAVK-IFPLQDKQSWQ-SEREIFSTPGMKHENLLQFI 75 Query: 104 RDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDHICYFLYQILRGLKYIH---- 158 R S LE +++++ + L LK ++ + +C+ + RGL Y+H Sbjct: 76 AAEKRGSNLEV--ELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVP 133 Query: 159 -------SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 ++ HRD K N+L+ + + DFGLA +P G V TR Y Sbjct: 134 WCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKP-PGDTHGQVGTRRYM 192 Query: 212 APEIMLNSKGYTKS----IDIWSVGCILAEMLS 240 APE++ + + + ID++++G +L E++S Sbjct: 193 APEVLEGAINFQRDAFLRIDMYAMGLVLWELVS 225 >4YFF-A nrPDB Length = 311 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 88/209 (42%), Gaps = 19/209 (9%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT-----LREIQILLRFRHENV 100 + IG G++G V R VAIK+ + TYC ++ RE+ IL + H V Sbjct: 48 EIIGSGSFGKVYKG--RCRNKIVAIKR---YRANTYCSKSDVDMFCREVSILCQLNHPCV 102 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ--LSNDHICYFLYQILRGLKYIH 158 I + A + + + Q + L+ LL Q+ L + +G++Y+H Sbjct: 103 I---QFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLH 159 Query: 159 SAN--VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 + ++HRDL N+L+ + DFG +R D + RW APE+ Sbjct: 160 NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQ-SLDEDNMTKQPGNLRWM-APEVF 217 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 YT D++S L E+L+ F Sbjct: 218 TQCTRYTIKADVFSYALCLWEILTGEIPF 246 >3TXO-A nrPDB Length = 353 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 37/131 (28%), Positives = 65/131 (49%), Gaps = 6/131 (4%) Query: 129 LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLA 188 ++ + KS++ ++ +I+ L ++H +++RDLK N+L++ K+ DFG+ Sbjct: 112 MFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMC 171 Query: 189 RIADPEHDHTGFLTE-YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 247 + E G T + T Y APEI L Y ++D W++G +L EML F Sbjct: 172 K----EGICNGVTTATFCGTPDYIAPEI-LQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA 226 Query: 248 KHYLDQLNHIL 258 ++ D IL Sbjct: 227 ENEDDLFEAIL 237 >3BBT-B nrPDB Length = 328 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 47/211 (22%), Positives = 93/211 (44%), Gaps = 13/211 (6%) Query: 44 QLQYIGEGAYGMVSSAY----DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 +++ +G GA+G V K VAIK ++ + E I+ H + Sbjct: 19 RVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPH 78 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159 ++ + + + T++ + + L+E Y + + + + QI +G+ Y+ Sbjct: 79 LVRLLGVCLSPTIQLVTQLMPHGCLLE---YVHEHKDNIGSQLLLNWCVQIAKGMMYLEE 135 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 ++HRDL N+L+ + +KI DFGLAR+ + + + +W I + Sbjct: 136 RRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECI--HY 193 Query: 220 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHY 250 + +T D+WS G + E+++ F GK Y Sbjct: 194 RKFTHQSDVWSYGVTIWELMT----FGGKPY 220 >4YHJ-A nrPDB Length = 584 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 45/160 (28%), Positives = 74/160 (46%), Gaps = 17/160 (10%) Query: 145 YFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEY 204 ++ ++ GL+ + +++RDLKP N+L++ ++I D GLA PE + Sbjct: 291 FYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLA-TEIPEGQR---VRGR 346 Query: 205 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP 264 V T Y APE++ N K YT S D W +GC++ EM+ P K Y +++ Sbjct: 347 VGTVGYMAPEVVNNEK-YTFSPDWWGLGCLIYEMIQGHS--PFKKYKEKVKW-------- 395 Query: 265 SQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKAL 304 E+++ I Y + K L K+ SK L Sbjct: 396 --EEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRL 433 >4EBW-A nrPDB Length = 304 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 50/200 (25%), Positives = 96/200 (48%), Gaps = 19/200 (9%) Query: 48 IGEGAYGMVSSAYDHVRKT---RVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 IGEG +G V + VAIK + ++ L+E + +F H +++ + Sbjct: 46 IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI 105 Query: 105 DILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSND--HICYFLYQILRGLKYIHSAN 161 ++ + V+I+ +L +L L+ ++ S D + + YQ+ L Y+ S Sbjct: 106 GVITENP------VWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKR 159 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE--YVATRWYRAPEIMLNS 219 +HRD+ N+L+++ +K+ DFGL+R + D T + + +W APE +N Sbjct: 160 FVHRDIAARNVLVSSNDCVKLGDFGLSRYME---DSTYYKASKGKLPIKWM-APE-SINF 214 Query: 220 KGYTKSIDIWSVGCILAEML 239 + +T + D+W G + E+L Sbjct: 215 RRFTSASDVWMFGVCMWEIL 234 >1PY5-A nrPDB Length = 326 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 68/274 (24%), Positives = 115/274 (41%), Gaps = 31/274 (11%) Query: 17 TEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF 76 T G G G+P V+ + + IG+G +G V R VA+K S Sbjct: 12 TSGSGSGLPLLVQRT------IARTIVLQESIGKGRFGEVWRG--KWRGEEVAVKIFSSR 63 Query: 77 EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLE--AMRDVYIVQDLME-TDLYKLL 133 E +++ + EI + RHEN++G + A + +++V D E L+ L Sbjct: 64 EERSWFREA--EIYQTVMLRHENILGF---IAADNKDNGTWTQLWLVSDYHEHGSLFDYL 118 Query: 134 KSQQLSNDHICYFLYQILRGLKYIH--------SANVLHRDLKPSNLLINTTCDLKICDF 185 ++ + + GL ++H + HRDLK N+L+ I D Sbjct: 119 NRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADL 178 Query: 186 GLARIADPEHDHTGFLTEY-VATRWYRAPEIM---LNSKGYT--KSIDIWSVGCILAEML 239 GLA D D + V T+ Y APE++ +N K + K DI+++G + E + Sbjct: 179 GLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWE-I 237 Query: 240 SNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 + R G H QL + + PS E++ ++ Sbjct: 238 ARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVV 271 >3PP0-A nrPDB Length = 338 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 33/108 (30%), Positives = 54/108 (50%), Gaps = 7/108 (6%) Query: 133 LKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIAD 192 L SQ L N + QI +G+ Y+ ++HRDL N+L+ + +KI DFGLAR+ D Sbjct: 116 LGSQDLLN-----WCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLD 170 Query: 193 PEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + V +W I+ + +T D+WS G + E+++ Sbjct: 171 IDETEYHADGGKVPIKWMALESIL--RRRFTHQSDVWSYGVTVWELMT 216 >5TE0-A nrPDB Length = 347 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 108/238 (45%), Gaps = 25/238 (10%) Query: 17 TEGVGPGVPGEVEMVKGQPFDVGPRYTQL-QYIGEGAYGMVSSAYDHVRKTRVAIKKISP 75 T G+G G G V F +G + + + + EG + +V + A+K++ Sbjct: 2 TSGLGSGYIGRV-------FGIGRQQVTVDEVLAEGGFAIVFLVRTS-NGMKCALKRMF- 52 Query: 76 FEHQTYCQRTLREIQILLRFR-HENVIG-IRDILRASTLEAMRDVYIVQDLMETDLYKLL 133 ++ Q REIQI+ H+N++G I + + + +V I+ D L Sbjct: 53 VNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNL 112 Query: 134 KSQQL----SNDHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLLINTTCDLKICDFGL 187 +Q+L + + + + +H ++HRDLK N+L++ +CDFG Sbjct: 113 MNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGS 172 Query: 188 A--RIADPEHDHTGFLTEYV---ATRWYRAPEI--MLNSKGYTKSIDIWSVGCILAEM 238 A + +P+ + + + + T YRAPE+ + + K T DIW++GC+L ++ Sbjct: 173 ATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKL 230 >6FER-A nrPDB Length = 309 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 45/184 (24%), Positives = 79/184 (42%), Gaps = 17/184 (9%) Query: 68 VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET 127 VA+K + ++ L+EI+I+ R + N+I + + M I + + Sbjct: 53 VAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCM----ITEYMENG 108 Query: 128 DLYKLLKSQQ-----------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT 176 DL + L + +S ++ + QI G+KY+ S N +HRDL N L+ Sbjct: 109 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK 168 Query: 177 TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILA 236 +KI DFG++R + + RW I+L +T + D+W+ G L Sbjct: 169 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGK--FTTASDVWAFGVTLW 226 Query: 237 EMLS 240 E + Sbjct: 227 ETFT 230 >4X7Q-B nrPDB Length = 312 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 90/210 (42%), Gaps = 29/210 (13%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKI--------SPFEHQTYCQRTLREIQILLRFR--- 96 +G+G +G V + + + +VAIK I SP C E+ +L + Sbjct: 39 LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL---EVALLWKVGAGG 95 Query: 97 -HENVIGIRDILRAST--LEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 H VI + D + + QDL + Y K C+F Q++ Sbjct: 96 GHPGVIRLLDWFETQEGFMLVLERPLPAQDLFD---YITEKGPLGEGPSRCFF-GQVVAA 151 Query: 154 LKYIHSANVLHRDLKPSNLLINT--TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 +++ HS V+HRD+K N+LI+ C K+ DFG + HD T++ TR Y Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLRRGC-AKLIDFGSGALL---HDEP--YTDFDGTRVYS 205 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSN 241 PE + + + +WS+G +L +M+ Sbjct: 206 PPEWISRHQYHALPATVWSLGILLYDMVCG 235 >5FM2-A nrPDB Length = 355 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 31/105 (29%), Positives = 55/105 (52%), Gaps = 2/105 (1%) Query: 136 QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH 195 + L+ + F +QI +G++Y+ ++HRDL N+L+ +KI DFGL+R E Sbjct: 186 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED 245 Query: 196 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + + +W A E + + YT D+WS G +L E+++ Sbjct: 246 SYVKRSQGRIPVKWM-AIESLFDHI-YTTQSDVWSFGVLLWEIVT 288 >3MY0-A nrPDB Length = 305 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 90/217 (41%), Gaps = 19/217 (8%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 ++ +G+G YG V H VA+K S + Q++ + T EI + RH+N++G Sbjct: 13 VECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFRET--EIYNTVLLRHDNILGFI 68 Query: 105 DILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH------ 158 S + + I LY L+ Q L GL ++H Sbjct: 69 ASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGT 128 Query: 159 --SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVATRWYRAPEI 215 + HRD K N+L+ + I D GLA + D+ V T+ Y APE+ Sbjct: 129 QGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEV 188 Query: 216 M---LNSKGYT--KSIDIWSVGCILAEMLSNRPIFPG 247 + + + + K DIW+ G +L E ++ R I G Sbjct: 189 LDEQIRTDCFESYKWTDIWAFGLVLWE-IARRTIVNG 224 >3V5Q-A nrPDB Length = 297 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 93/222 (41%), Gaps = 31/222 (13%) Query: 48 IGEGAYGMV--SSAYDHVRKTRVAIKKISPFEHQTYCQRT--LREIQILLRFRHENVIGI 103 +GEGA+G V + Y+ + + + T R RE ++L +HE+++ Sbjct: 23 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF 82 Query: 104 RDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ-----------------QLSNDHICYF 146 + M + + + DL K L++ +L + + Sbjct: 83 YGVCGDGDPLIM----VFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHI 138 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYV 205 QI G+ Y+ S + +HRDL N L+ +KI DFG++R + ++ G T + Sbjct: 139 ASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHT-ML 197 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS--NRPIF 245 RW IM + +T D+WS G IL E+ + +P F Sbjct: 198 PIRWMPPESIMY--RKFTTESDVWSFGVILWEIFTYGKQPWF 237 >5KMM-A nrPDB Length = 329 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 64/253 (25%), Positives = 109/253 (43%), Gaps = 38/253 (15%) Query: 17 TEGVGPGVPGEVEMVKGQPFD------VGPRYTQLQY-IGEGAYGMVSSAYDH-----VR 64 TEG G G+ G + + Q F + R L++ +GEGA+G V A H Sbjct: 6 TEGKGSGLQGHI-IENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQD 64 Query: 65 KTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDL 124 K VA+K + ++ Q RE ++L +H++++ + E + + + + Sbjct: 65 KMLVAVKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGV----CTEGRPLLMVFEYM 119 Query: 125 METDLYKLLKSQQ----------------LSNDHICYFLYQILRGLKYIHSANVLHRDLK 168 DL + L+S L + Q+ G+ Y+ + +HRDL Sbjct: 120 RHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLA 179 Query: 169 PSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSID 227 N L+ +KI DFG++R I ++ G T + RW PE +L K +T D Sbjct: 180 TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT-MLPIRWM-PPESILYRK-FTTESD 236 Query: 228 IWSVGCILAEMLS 240 +WS G +L E+ + Sbjct: 237 VWSFGVVLWEIFT 249 >5U6B-A nrPDB Length = 307 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 52/220 (23%), Positives = 96/220 (43%), Gaps = 29/220 (13%) Query: 48 IGEGAYGMVSSAY----DHVRKTRVAIKKISPFEHQTYCQRT-----LREIQILLRFRHE 98 +GEG +G V D + K V KI+ C R+ L E + F H Sbjct: 31 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIA------ICTRSELEDFLSEAVCMKEFDHP 84 Query: 99 NVIGIRDI-LRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSNDHI-------CYFLYQ 149 NV+ + + + S E+ ++ M+ DL+ L +L + + F+ Sbjct: 85 NVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMAD 144 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLA-RIADPEHDHTGFLTEYVATR 208 I G++Y+ + +HRDL N ++N + + DFGL+ +I + ++ G + + + + Sbjct: 145 IASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAK-MPVK 203 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPG 247 W L + YT D+WS G + E+ + + +PG Sbjct: 204 WIAIES--LADRVYTSKSDVWSFGVTMWEIATRGQTPYPG 241 >5LPZ-A nrPDB Length = 332 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/201 (25%), Positives = 96/201 (47%), Gaps = 12/201 (5%) Query: 48 IGEGAYGMVSSAYDHVRK--TRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 IG G +G V Y + K + VAIKK+ Q + + E++ + + +H N++ + Sbjct: 25 IGSGGFGDV---YKAILKDGSAVAIKKLIHVSGQGD-REFMAEMETIGKIKHRNLVPLLG 80 Query: 106 ILRASTLEAMRDVYIVQDLMETDLYKLLKSQ-QLSNDHICYFLYQILRGLKYIH---SAN 161 + + ++ +E L+ K+ +L+ RGL ++H S + Sbjct: 81 YCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPH 140 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKG 221 ++HRD+K SN+L++ + ++ DFG+AR+ H T T Y PE + + Sbjct: 141 IIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVST-LAGTPGYVPPEYYQSFRC 199 Query: 222 YTKSIDIWSVGCILAEMLSNR 242 TK D++S G +L E+L+ + Sbjct: 200 STKG-DVYSYGVVLLELLTGK 219 >3Q4U-A nrPDB Length = 301 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 90/217 (41%), Gaps = 22/217 (10%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 T L+ +G+G YG V + VA+K S + +++ + T E+ + RHEN++G Sbjct: 11 TLLECVGKGRYGEVWRG--SWQGENVAVKIFSSRDEKSWFRET--ELYNTVMLRHENILG 66 Query: 103 IRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH---- 158 S + + I LY L+ L + I GL ++H Sbjct: 67 FIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF 126 Query: 159 ----SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVATRWYRAP 213 + HRDLK N+L+ I D GLA + + V T+ Y AP Sbjct: 127 GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAP 186 Query: 214 EIM-----LNSKGYTKSIDIWSVGCILAE----MLSN 241 E++ ++ K +DIW+ G +L E M+SN Sbjct: 187 EVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSN 223 >5AR8-A nrPDB Length = 326 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 93/213 (43%), Gaps = 8/213 (3%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQR--TLREIQILLRFRHE 98 + L+Y+ GA G VSSA + +VA+K + +R LRE +IL + R Sbjct: 33 KLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFS 92 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 ++ I I + Y+ + L++ + ++ L++I G+ Y+H Sbjct: 93 YILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLH 152 Query: 159 SAN--VLHRDLKPSNLLINTTCDLKICDFGLA--RIADPEHDHTGFLTEYVATRWYRAPE 214 + +LH DLK N+L++ +KI DFGL+ R+ + T Y PE Sbjct: 153 NMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPE 212 Query: 215 IMLNSKGYTKSI--DIWSVGCILAEMLSNRPIF 245 + SI DI+S I E+LS + F Sbjct: 213 NYEPGQKSRASIKHDIYSYAVITWEVLSRKQPF 245 >5LPV-A nrPDB Length = 296 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 51/201 (25%), Positives = 96/201 (47%), Gaps = 12/201 (5%) Query: 48 IGEGAYGMVSSAYDHVRK--TRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 IG G +G V Y + K + VAIKK+ Q + + E++ + + +H N++ + Sbjct: 25 IGSGGFGDV---YKAILKDGSAVAIKKLIHVSGQGD-REFMAEMETIGKIKHRNLVPLLG 80 Query: 106 ILRASTLEAMRDVYIVQDLMETDLYKLLKSQ-QLSNDHICYFLYQILRGLKYIH---SAN 161 + + ++ +E L+ K+ +L+ RGL ++H S + Sbjct: 81 YCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPH 140 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKG 221 ++HRD+K SN+L++ + ++ DFG+AR+ H T T Y PE + + Sbjct: 141 IIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVST-LAGTPGYVPPEYYQSFRC 199 Query: 222 YTKSIDIWSVGCILAEMLSNR 242 TK D++S G +L E+L+ + Sbjct: 200 STKG-DVYSYGVVLLELLTGK 219 >2QKW-B nrPDB Length = 321 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 33/91 (36%), Positives = 50/91 (54%), Gaps = 2/91 (2%) Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 RGL Y+H+ ++HRD+K N+L++ KI DFG+++ E D T T T Y Sbjct: 150 RGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISK-KGTELDQTHLSTVVKGTLGYI 208 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNR 242 PE + + KS D++S G +L E+L R Sbjct: 209 DPEYFIKGRLTEKS-DVYSFGVVLFEVLCAR 238 >3I81-A nrPDB Length = 315 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 57/237 (24%), Positives = 105/237 (44%), Gaps = 37/237 (15%) Query: 24 VPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRK--------TRVAIKKISP 75 VP E E+ + + T + +G+G++GMV Y+ V K TRVAIK ++ Sbjct: 9 VPDEWEVAR-------EKITMSRELGQGSFGMV---YEGVAKGVVKDEPETRVAIKTVNE 58 Query: 76 FEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS 135 L E ++ F +V+ + ++ + + I++ + DL L+S Sbjct: 59 AASMRERIEFLNEASVMKEFNCHHVVRLLGVVS----QGQPTLVIMELMTRGDLKSYLRS 114 Query: 136 --QQLSND---------HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICD 184 ++ N+ + +I G+ Y+++ +HRDL N ++ +KI D Sbjct: 115 LRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGD 174 Query: 185 FGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 FG+ R I + ++ G + RW +PE L +T D+WS G +L E+ + Sbjct: 175 FGMTRDIYETDYYRKGG-KGLLPVRWM-SPE-SLKDGVFTTYSDVWSFGVVLWEIAT 228 >3TKU-A nrPDB Length = 433 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 63/237 (26%), Positives = 107/237 (45%), Gaps = 44/237 (18%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR-----FRHEN 99 ++ IG GA+G VA+ K+ E + Y + L + ++L R FR E Sbjct: 95 IKVIGRGAFG------------EVAVVKMKNTE-RIYAMKILNKWEMLKRAETACFREE- 140 Query: 100 VIGIRDILRASTLE-------AMRD---VYIVQDL-METDLYKLLK--SQQLSNDHICYF 146 RD+L + A +D +Y+V D + DL LL +L D ++ Sbjct: 141 ----RDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFY 196 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFG-LARIADPEHDHTGFLTEYV 205 + +++ + IH + +HRD+KP N+L++ +++ DFG ++ D D T + V Sbjct: 197 IGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMND---DGTVQSSVAV 253 Query: 206 ATRWYRAPEI---MLNSKG-YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL 258 T Y +PEI M + G Y D WS+G + EML F + ++ I+ Sbjct: 254 GTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIM 310 >3ZZW-A nrPDB Length = 289 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 37/119 (31%), Positives = 61/119 (51%), Gaps = 3/119 (2%) Query: 122 QDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLK 181 D+ TD + +KS D + + + QI G++Y+ S +V+H+DL N+L+ ++K Sbjct: 110 SDVGSTDDDRTVKSALEPPDFV-HLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVK 168 Query: 182 ICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 I D GL R + + RW APE ++ K ++ DIWS G +L E+ S Sbjct: 169 ISDLGLFREVYAADYYKLLGNSLLPIRWM-APEAIMYGK-FSIDSDIWSYGVVLWEVFS 225 >4AW2-A nrPDB Length = 437 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 55/224 (24%), Positives = 102/224 (45%), Gaps = 16/224 (7%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEH----QTYCQRTLREIQILLRFRHENV 100 L+ IG GA+G V+ A+K ++ +E +T C R R++ L+ + + Sbjct: 79 LKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDV--LVNGDSKWI 136 Query: 101 IGIRDILRA-STLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159 + + + L + D Y+ DL+ T L K +L + ++L +++ + +H Sbjct: 137 TTLHYAFQDDNNLYLVMDYYVGGDLL-TLLSKF--EDRLPEEMARFYLAEMVIAIDSVHQ 193 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 + +HRD+KP N+L++ +++ DFG D T + V T Y +PEI+ Sbjct: 194 LHYVHRDIKPDNILMDMNGHIRLADFG--SCLKLMEDGTVQSSVAVGTPDYISPEILQAM 251 Query: 220 KG----YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 259 +G Y D WS+G + EML F + ++ I+ Sbjct: 252 EGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN 295 >3SXS-A nrPDB Length = 268 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 49/206 (23%), Positives = 89/206 (43%), Gaps = 24/206 (11%) Query: 43 TQLQYIGEGAYGMVS-----SAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 T L+ +G G +G+V YD VA+K I E +E Q +++ H Sbjct: 11 TLLKELGSGQFGVVKLGKWKGQYD------VAVKMIK--EGSMSEDEFFQEAQTMMKLSH 62 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLKS--QQLSNDHICYFLYQILRGL 154 ++ + +YIV + + L L+S + L + Y + G+ Sbjct: 63 PKLVKFYGVCSKEY-----PIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGM 117 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 ++ S +HRDL N L++ +K+ DFG+ R + + T++ +W APE Sbjct: 118 AFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKF-PVKW-SAPE 175 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLS 240 + K Y+ D+W+ G ++ E+ S Sbjct: 176 VFHYFK-YSSKSDVWAFGILMWEVFS 200 >4H1J-A nrPDB Length = 293 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 48/203 (23%), Positives = 93/203 (45%), Gaps = 11/203 (5%) Query: 48 IGEGAYGMV-SSAYDHVR--KTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 +GEG +G V Y + + K VA+K ++ + E I+ H +++ + Sbjct: 32 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLI 91 Query: 105 DILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLH 164 I+ + ++Y +L Y L + + QI + + Y+ S N +H Sbjct: 92 GIIEEEPTWIIMELYPYGELGH---YLERNKNSLKVLTLVLYSLQICKAMAYLESINCVH 148 Query: 165 RDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTK 224 RD+ N+L+ + +K+ DFGL+R + E + +T + +W +PE +N + +T Sbjct: 149 RDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTR-LPIKW-MSPE-SINFRRFTT 205 Query: 225 SIDIWSVGCILAEMLS--NRPIF 245 + D+W + E+LS +P F Sbjct: 206 ASDVWMFAVCMWEILSFGKQPFF 228 >3UIM-A nrPDB Length = 326 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 49/208 (23%), Positives = 93/208 (44%), Gaps = 8/208 (3%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 ++ +G G +G V T VA+K++ Q + E++++ H N++ Sbjct: 32 FSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLL 90 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHS- 159 +R T + Y+ + + L + +SQ L RGL Y+H Sbjct: 91 RLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDH 150 Query: 160 --ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 ++HRD+K +N+L++ + + DFGLA++ D + H T T + APE + Sbjct: 151 CDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHV--TTAVRGTIGHIAPEYLS 208 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIF 245 K K+ D++ G +L E+++ + F Sbjct: 209 TGKSSEKT-DVFGYGVMLLELITGQRAF 235 >5E8V-A nrPDB Length = 316 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 50/211 (23%), Positives = 90/211 (42%), Gaps = 19/211 (9%) Query: 48 IGEGAYGMVSSA---YDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 +G+G + V A + + KI P+E + +T ++I + +HEN++ Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYE-EYASWKTEKDIFSDINLKHENILQFL 75 Query: 105 DILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSAN--- 161 T + I + +L + L +S + + + RG+ ++HS + Sbjct: 76 TAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPC 135 Query: 162 ------VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVATRWYRAPE 214 ++HRDLK SN+L+ +CDFGL+ DP V T Y APE Sbjct: 136 GRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPE 195 Query: 215 IMLNSKGYT-----KSIDIWSVGCILAEMLS 240 ++ ++ K D++S+ +L EM S Sbjct: 196 VLASAMNLENVESFKQTDVYSMALVLWEMTS 226 >1LUF-A nrPDB Length = 343 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 54/219 (24%), Positives = 85/219 (38%), Gaps = 28/219 (12%) Query: 48 IGEGAYGMVSSA-----YDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI- 101 IGEGA+G V A + T VA+K + RE ++ F + N++ Sbjct: 55 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVK 114 Query: 102 --GIRDILRASTL-----------EAMRDV--YIVQDLMETDLYKLLKSQQ-----LSND 141 G+ + + L E +R + + V L +DL + LS Sbjct: 115 LLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCA 174 Query: 142 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFL 201 Q+ G+ Y+ +HRDL N L+ +KI DFGL+R + Sbjct: 175 EQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKADG 234 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 + + RW I N YT D+W+ G +L E+ S Sbjct: 235 NDAIPIRWMPPESIFYNR--YTTESDVWAYGVVLWEIFS 271 >3G2F-A nrPDB Length = 336 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 60/256 (23%), Positives = 108/256 (42%), Gaps = 33/256 (12%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 L+ IG G YG V + + VA+K S Q + + I + H+N+ R Sbjct: 18 LELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFINE--KNIYRVPLMEHDNIA--R 71 Query: 105 DIL---RASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSA- 160 I+ R + M + +++ L K L C + + RGL Y+H+ Sbjct: 72 FIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTEL 131 Query: 161 --------NVLHRDLKPSNLLINTTCDLKICDFGLA------RIADPEHDHTGFLTEYVA 206 + HRDL N+L+ I DFGL+ R+ P + ++E V Sbjct: 132 PRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISE-VG 190 Query: 207 TRWYRAPEI------MLNSKGYTKSIDIWSVGCILAEM-LSNRPIFPGKHYLD-QLNHIL 258 T Y APE+ + + + K +D++++G I E+ + +FPG+ + Q+ Sbjct: 191 TIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQT 250 Query: 259 GILGSPSQEDLNCIIN 274 + P+ ED+ +++ Sbjct: 251 EVGNHPTFEDMQVLVS 266 >3LMG-A nrPDB Length = 344 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 39/201 (19%), Positives = 82/201 (40%), Gaps = 9/201 (4%) Query: 44 QLQYIGEGAYGMVSSAY----DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 +L+ +G G +G V K V IK I + Q + + H + Sbjct: 35 KLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAH 94 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159 ++ + + S+L+ + + L++ + L + + QI +G+ Y+ Sbjct: 95 IVRLLGLCPGSSLQLVTQYLPLGSLLD---HVRQHRGALGPQLLLNWGVQIAKGMYYLEE 151 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 ++HR+L N+L+ + +++ DFG+A + P+ + +W I Sbjct: 152 HGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGK 211 Query: 220 KGYTKSIDIWSVGCILAEMLS 240 YT D+WS G + E+++ Sbjct: 212 --YTHQSDVWSYGVTVWELMT 230 >5VD3-A nrPDB Length = 311 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 54/219 (24%), Positives = 92/219 (42%), Gaps = 15/219 (6%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKK-ISPFEHQTYCQRTLREIQILLRFRHENV 100 + +L +G G+YG V A+K+ +SPF R L E+ HE V Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVG-----SHEKV 113 Query: 101 IGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKS--QQLSNDHICYFLYQILRGLKYI 157 +R E +Y+ +L L + ++ L + +L L L ++ Sbjct: 114 GQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHL 173 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 HS ++H D+KP+N+ + K+ DFGL + + G + E Y APE++ Sbjct: 174 HSQGLVHLDVKPANIFLGPRGRCKLGDFGL--LVELGTAGAGEVQE--GDPRYMAPELLQ 229 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 S Y + D++S+G + E+ N + G QL Sbjct: 230 GS--YGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ 266 >5L2Q-C nrPDB Length = 320 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 33/118 (27%), Positives = 61/118 (51%), Gaps = 5/118 (4%) Query: 123 DLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDLK 181 DL+ Y ++K ++LS Y ++R ++ +H N++HRDLK N+++N T + Sbjct: 136 DLINLQHY-VIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRIT 194 Query: 182 ICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239 I +F L + E D L + + Y +P+++ K D+W++G +L ML Sbjct: 195 ITNFCLGKHLVSEGD---LLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTML 249 >4F0G-A nrPDB Length = 287 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 88/213 (41%), Gaps = 26/213 (12%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKI------SPFEHQTYCQRTLREIQILLRFRHENVI 101 IG+G +G+V K+ VAIK + E Q RE+ I+ H N++ Sbjct: 27 IGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPNIV 86 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLL--KSQQLSNDHICYFLYQILRGLKYIHS 159 + ++ M V DLY L K+ + + I G++Y+ + Sbjct: 87 KLYGLMHNPPRMVMEFVPC------GDLYHRLLDKAHPIKWSVKLRLMLDIALGIEYMQN 140 Query: 160 AN--VLHRDLKPSNLLI-----NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 N ++HRDL+ N+ + N K+ DFGL++ + H +G L + +W Sbjct: 141 QNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQS--VHSVSGLLGNF---QWMAP 195 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 I + YT+ D +S IL +L+ F Sbjct: 196 ETIGAEEESYTEKADTYSFAMILYTILTGEGPF 228 >5X1R-A nrPDB Length = 302 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 58/222 (26%), Positives = 88/222 (39%), Gaps = 35/222 (15%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFE--------------------HQTYCQRTLR 87 IGEG +G+V AYDH + +AIK+ P Q ++ Sbjct: 29 IGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAGLNSFIQ 88 Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ---LSNDHIC 144 E ++L RF H G+ +LR E Y+ K L++QQ + I Sbjct: 89 EARLLARFSHP---GLLHVLR--FWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDEAWIR 143 Query: 145 YFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEY 204 L + + IH LHRD+ N+ I + + DFG AR E + TE Sbjct: 144 RLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSAR---KEIGNLSDETEI 200 Query: 205 VATRWYRAP--EIMLNSKGYTKS-IDIWSVGCILAEMLSNRP 243 V + AP + NS G DI+++G +L ++ P Sbjct: 201 VLKPGF-APIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSP 241 >4EUU-A nrPDB Length = 319 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 48/199 (24%), Positives = 86/199 (43%), Gaps = 13/199 (6%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G+GA V AIK + +RE ++L + H+N++ + I Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 76 Query: 108 RASTLEAMRDVYIVQDLMETDLYKLLK----SQQLSNDHICYFLYQILRGLKYIHSANVL 163 +T V I++ LY +L+ + L L ++ G+ ++ ++ Sbjct: 77 EETT--TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 134 Query: 164 HRDLKPSNLLINTTCD----LKICDFGLAR-IADPEHDHTGFLT-EYVATRWY-RAPEIM 216 HR++KP N++ D K+ DFG AR + D E + + T EY+ Y RA Sbjct: 135 HRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 194 Query: 217 LNSKGYTKSIDIWSVGCIL 235 + K Y ++D+WS+G Sbjct: 195 DHQKKYGATVDLWSIGVTF 213 >4NFN-A nrPDB Length = 309 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 90/218 (41%), Gaps = 32/218 (14%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR- 96 V R+ L+ IG G +G + A D + + VA+K S Q Q E+ +L + + Sbjct: 19 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESA---QQPKQVLKMEVAVLKKLQG 75 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY---QILRG 153 ++V R Y+V L +L L +SQ + L QIL Sbjct: 76 KDHVCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILES 130 Query: 154 LKYIHSANVLHRDLKPSNL----LINTTCDLKICDFGLARI-------ADPEHDHTGF-- 200 ++ IHS LHRD+KPSN L +T + DFGLAR P + GF Sbjct: 131 IEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRG 190 Query: 201 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM 238 Y + ++ E+ + D+WS+ +L E Sbjct: 191 TVRYASVNAHKNREM-------GRHDDLWSLFYMLVEF 221 >3QUP-A nrPDB Length = 323 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/234 (21%), Positives = 107/234 (45%), Gaps = 18/234 (7%) Query: 41 RYTQLQYIGEGAYGMVSSAY---DHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFR 96 ++T + +G+G +G V A + +VA+K + + + + LRE + F Sbjct: 24 QFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFD 83 Query: 97 HENVIGIRDI-LRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSND-------HICYFL 147 H +V + + LR+ + ++ M+ DL+ L + ++ + + F+ Sbjct: 84 HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFM 143 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVA 206 I G++Y+ S N +HRDL N ++ + + DFGL+R I ++ G ++ + Sbjct: 144 VDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASK-LP 202 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILG 259 +W + N YT D+W+ G + E+++ + + G + N+++G Sbjct: 203 VKWLALESLADNL--YTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIG 254 >4LQP-A nrPDB Length = 508 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 39/164 (23%), Positives = 79/164 (48%), Gaps = 25/164 (15%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 ++ IG+GA+G V R+ KK + + Y +TL + ++ + + +V R Sbjct: 107 VKVIGKGAFGEV----------RLVQKKDTG---KIYAMKTLLKSEMYKKDQLAHVKAER 153 Query: 105 DILRAS----------TLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDHIC-YFLYQILR 152 D+L S + + + +Y++ + + DL +L QL + + +++ + + Sbjct: 154 DVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECIL 213 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 ++ IH +HR +KP N+LI+ +K+ DFGL+ HD Sbjct: 214 AIETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHD 257 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 19/41 (46%), Positives = 23/41 (56%), Gaps = 1/41 (2%) Query: 205 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 V T Y APEI L +GY + D WS+G I+ E L P F Sbjct: 324 VGTPDYIAPEIFL-YQGYGQECDWWSLGAIMYECLIGWPPF 363 >4BTK-A nrPDB Length = 337 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 90/218 (41%), Gaps = 32/218 (14%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR- 96 V R+ L+ IG G +G + A D + + VA+K S Q Q E+ +L + + Sbjct: 54 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESA---QQPKQVLKMEVAVLKKLQG 110 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY---QILRG 153 ++V R Y+V L +L L +SQ + L QIL Sbjct: 111 KDHVCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILES 165 Query: 154 LKYIHSANVLHRDLKPSNL----LINTTCDLKICDFGLARI-------ADPEHDHTGF-- 200 ++ IHS LHRD+KPSN L +T + DFGLAR P + GF Sbjct: 166 IEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRG 225 Query: 201 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM 238 Y + ++ E+ + D+WS+ +L E Sbjct: 226 TVRYASVNAHKNREM-------GRHDDLWSLFYMLVEF 256 >4EUT-A nrPDB Length = 396 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 48/199 (24%), Positives = 86/199 (43%), Gaps = 13/199 (6%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G+GA V AIK + +RE ++L + H+N++ + I Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 76 Query: 108 RASTLEAMRDVYIVQDLMETDLYKLLK----SQQLSNDHICYFLYQILRGLKYIHSANVL 163 +T V I++ LY +L+ + L L ++ G+ ++ ++ Sbjct: 77 EETT--TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 134 Query: 164 HRDLKPSNLLINTTCD----LKICDFGLAR-IADPEHDHTGFLT-EYVATRWY-RAPEIM 216 HR++KP N++ D K+ DFG AR + D E + + T EY+ Y RA Sbjct: 135 HRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 194 Query: 217 LNSKGYTKSIDIWSVGCIL 235 + K Y ++D+WS+G Sbjct: 195 DHQKKYGATVDLWSIGVTF 213 >5U6C-A nrPDB Length = 315 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 49/212 (23%), Positives = 92/212 (43%), Gaps = 17/212 (8%) Query: 48 IGEGAYGMVSSA---YDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENVIGI 103 +GEG +G V + +VA+K + Q + L E + F H NV+ + Sbjct: 44 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVMRL 103 Query: 104 RDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSN--DHI-----CYFLYQILRGLK 155 + + + + ++ M+ DL+ L +L HI F+ I G++ Sbjct: 104 LGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGME 163 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLA-RIADPEHDHTGFLTEYVATRWYRAPE 214 Y+ + N LHRDL N ++ + + DFGL+ +I ++ G + + + +W Sbjct: 164 YLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAK-MPVKWIAIES 222 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFP 246 L + YT D+W+ G + E ++ R + P Sbjct: 223 --LADRVYTSKSDVWAFGVTMWE-IATRGMTP 251 >5FQD-C nrPDB Length = 341 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 46/159 (28%), Positives = 76/159 (47%), Gaps = 12/159 (7%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95 F VG +Y ++ IG G++G + A + VA+K S + +IL Sbjct: 15 FIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKIL--- 71 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILRG 153 + +GI I R E +V +V DL+ L L S++ + + Q++ Sbjct: 72 --QGGVGIPHI-RWYGQEKDYNV-LVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISR 127 Query: 154 LKYIHSANVLHRDLKPSNLL--INTTCD-LKICDFGLAR 189 ++Y+H+ N +HRD+KP N L I C+ L + DFGLA+ Sbjct: 128 IEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAK 166 >4JLC-A nrPDB Length = 657 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 43/158 (27%), Positives = 76/158 (48%), Gaps = 13/158 (8%) Query: 86 LREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK----SQQLSND 141 +RE ++L + H+N++ + I +T V I++ LY +L+ + L Sbjct: 54 MREFEVLKKLNHKNIVKLFAIEEETT--TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPES 111 Query: 142 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD----LKICDFGLAR-IADPEHD 196 L ++ G+ ++ ++HRD+KP N++ D K+ DFG AR + D E Sbjct: 112 EFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQF 171 Query: 197 HTGFLT-EYVATRWY-RAPEIMLNSKGYTKSIDIWSVG 232 + + T EY+ Y RA + K Y ++D+WSVG Sbjct: 172 VSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVG 209 >6NT9-A nrPDB Length = 742 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 48/196 (24%), Positives = 86/196 (43%), Gaps = 13/196 (6%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G+GA V AIK + +RE ++L + H+N++ + I Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 Query: 108 RASTLEAMRDVYIVQDLMETDLYKLLK----SQQLSNDHICYFLYQILRGLKYIHSANVL 163 +T V I++ LY +L+ + L L ++ G+ ++ ++ Sbjct: 75 EETT--TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 Query: 164 HRDLKPSNLLINTTCD----LKICDFGLAR-IADPEHDHTGFLT-EYVATRWY-RAPEIM 216 HR++KP N++ D K+ DFG AR + D E + + T EY+ Y RA Sbjct: 133 HRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRK 192 Query: 217 LNSKGYTKSIDIWSVG 232 + K Y ++D+WS+G Sbjct: 193 DHQKKYGATVDLWSIG 208 >6O8B-A nrPDB Length = 665 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 46/201 (22%), Positives = 83/201 (41%), Gaps = 23/201 (11%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 107 +G+GA V AIK + +RE ++L + H+N++ + I Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 82 Query: 108 RASTLEAMRDVYIVQDLMETDLYKLLK----SQQLSNDHICYFLYQILRGLKYIHSANVL 163 +T V I++ LY +L+ + L L ++ G+ ++ ++ Sbjct: 83 EETT--TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 140 Query: 164 HRDLKPSNLLINTTCD----LKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLN 218 HR++KP N++ D K+ DFG AR + D E E T Y P++ Sbjct: 141 HRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ-----FVELYGTEEYLHPDMYER 195 Query: 219 S-------KGYTKSIDIWSVG 232 + K Y ++D+WS+G Sbjct: 196 AVLRKDHQKKYGATVDLWSIG 216 >2Y4I-B nrPDB Length = 319 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 54/219 (24%), Positives = 98/219 (44%), Gaps = 47/219 (21%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENVI--- 101 + IG+G +G V H VAI+ I +++ + RE+ + RHENV+ Sbjct: 39 ELIGKGRFGQVYHGRWH---GEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFM 95 Query: 102 ----------GIRDILRASTL-EAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQI 150 I + + TL +RD IV D+ K++Q++ + I Sbjct: 96 GACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVN--------KTRQIAQE--------I 139 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA---------DPEHDHTGFL 201 ++G+ Y+H+ +LH+DLK N+ + + I DFGL I+ D G+L Sbjct: 140 VKGMGYLHAKGILHKDLKSKNVFYDNG-KVVITDFGLFSISGVLQAGRREDKLRIQNGWL 198 Query: 202 TEYVATRWYR--APEIMLNSKGYTKSIDIWSVGCILAEM 238 ++A R +P+ + ++K D++++G I E+ Sbjct: 199 C-HLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYEL 236 >4L68-A nrPDB Length = 340 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 49/189 (25%), Positives = 86/189 (45%), Gaps = 17/189 (8%) Query: 77 EHQTYC---QRTLR-EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYK 131 +H + C +R R E+ L RH N + +L +E + ++V M L+ Sbjct: 70 KHLSTCKLGEREFRYEMNQLWELRHSN---LAPLLGFCVVE--EEKFLVYKYMSNGTLHS 124 Query: 132 LLKSQQLSNDHICYFLYQI--LRGLKYIHSAN---VLHRDLKPSNLLINTTCDLKICDFG 186 LL S + D F + RGL ++H +LH+++ S +LI+ D +I D G Sbjct: 125 LLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSG 184 Query: 187 LARIADP-EHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 LAR+ P +++ + F+T + Y APE K D++ +G +L E+ + Sbjct: 185 LARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKG-DVYGLGVVLLELATGLKAV 243 Query: 246 PGKHYLDQL 254 G+ + L Sbjct: 244 GGEGFKGSL 252 >4TN6-A nrPDB Length = 318 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 45/159 (28%), Positives = 76/159 (47%), Gaps = 16/159 (10%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIK-KISPFEH-QTYCQRTLREIQILLRF 95 VG RY + IG G++G + D VAIK + +H Q + + + ++ Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMM----- 59 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMET--DLYKLLKSQQLSNDHICYFLYQILRG 153 + +GI I R E +V +++ L + DL+ S++ S + Q++ Sbjct: 60 --QGGVGIPTI-RWCGAEGDYNVMVMELLGPSLEDLFNFC-SRKFSLKTVLLLADQMISR 115 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCD---LKICDFGLAR 189 ++YIHS N +HRD+KP N L+ + I DFGLA+ Sbjct: 116 IEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAK 154 >5VC6-A nrPDB Length = 289 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 43/154 (27%), Positives = 73/154 (47%), Gaps = 27/154 (17%) Query: 41 RYT----QLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRF 95 RYT +L+ IG G +G V + AIK+ P Q LRE+ + Sbjct: 8 RYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREV-----Y 62 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQD-------LME--TDLYKLL---KSQQLSNDHI 143 H + ++R + A D ++Q+ L + ++ Y+++ K +L + Sbjct: 63 AHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKD--- 119 Query: 144 CYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT 177 L Q+ RGL+YIHS +++H D+KPSN+ I+ T Sbjct: 120 --LLLQVGRGLRYIHSMSLVHMDIKPSNIFISRT 151 >2WTK-B nrPDB Length = 373 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 93/218 (42%), Gaps = 29/218 (13%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKT--RVAIKKIS----PFEHQTYCQRTLREIQIL 92 G Y L IG+G +++ + T V +++I+ E T+ Q E+ + Sbjct: 8 GGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQG---ELHVS 64 Query: 93 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSND----HICYFLY 148 F H N++ R +T A ++++V M K L + I Y L Sbjct: 65 KLFNHPNIVPYR-----ATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQ 119 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDF--GLARIADPE-----HDHTGFL 201 +L+ L YIH +HR +K S++LI+ + + L+ I+ + HD F Sbjct: 120 GVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHD---FP 176 Query: 202 TEYVATRWYRAPEIM-LNSKGYTKSIDIWSVGCILAEM 238 V + +PE++ N +GY DI+SVG E+ Sbjct: 177 KYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACEL 214 >2VD5-A nrPDB Length = 412 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 61/268 (22%), Positives = 113/268 (42%), Gaps = 36/268 (13%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR-----FRHEN 99 L+ IG GA+ + VA+ K+ Q Y + + + +L R FR E Sbjct: 66 LKVIGRGAF------------SEVAVVKMKQ-TGQVYAMKIMNKWDMLKRGEVSCFREER 112 Query: 100 VIGIRDILRASTL--EAMRD---VYIVQDL-METDLYKLLK--SQQLSNDHICYFLYQIL 151 + + R T A +D +Y+V + + DL LL +++ + ++L +I+ Sbjct: 113 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 172 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 + +H +HRD+KP N+L++ +++ DFG D T V T Y Sbjct: 173 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFG--SCLKLRADGTVRSLVAVGTPDYL 230 Query: 212 APEIM------LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 +PEI+ + Y D W++G EM + F + I+ S Sbjct: 231 SPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLS 290 Query: 266 QEDLNCIINMKARNYLQSL--PSKTKVA 291 ++ + +AR+++Q L P +T++ Sbjct: 291 LPLVDEGVPEEARDFIQRLLCPPETRLG 318 >3SV0-A nrPDB Length = 483 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 45/158 (28%), Positives = 77/158 (48%), Gaps = 14/158 (8%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEH-QTYCQRTLREIQILLRFR 96 VG ++ + IG G++G + + VAIK E+ +T + L E +I Sbjct: 5 VGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK----LENVKTKHPQLLYESKIYRIL- 59 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILRGL 154 + GI ++ R +E +V +V DL+ L L S++LS + Q++ + Sbjct: 60 -QGGTGIPNV-RWFGVEGDYNV-LVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRV 116 Query: 155 KYIHSANVLHRDLKPSNLLIN---TTCDLKICDFGLAR 189 +++HS + LHRD+KP N L+ + I DFGLA+ Sbjct: 117 EFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAK 154 >2LAV-A nrPDB Length = 361 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 42/171 (24%), Positives = 76/171 (44%), Gaps = 18/171 (10%) Query: 48 IGEGAYGMV----SSAYDHVRKTRVAIKKISP------FEHQTYCQRTLR--EIQILLRF 95 IG+G +G + ++ + V + K+ P F + QR + +IQ +R Sbjct: 43 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 102 Query: 96 RHENVIGIRDILRASTLEAMRDVY--IVQDLMETDLYKLLKS--QQLSNDHICYFLYQIL 151 R +G+ + + Y ++ D +DL K+ ++ ++ S + +IL Sbjct: 103 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRIL 162 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTC--DLKICDFGLARIADPEHDHTGF 200 L+YIH +H D+K SNLL+N + + D+GLA PE H + Sbjct: 163 DILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 >5CEK-A nrPDB Length = 263 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 56/243 (23%), Positives = 98/243 (40%), Gaps = 49/243 (20%) Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGLK 155 H N+ GI +++ T Y+ + D++ ++S++ L + QI+ + Sbjct: 60 HSNITGIVEVILGET-----KAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVA 114 Query: 156 YIHSANVLHRDLKPSNLLINTT--CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 + H + ++ DLK + +T L++ I E D L++ Y +P Sbjct: 115 HCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDD---ALSDKHGCPAYVSP 171 Query: 214 EIMLNSKGYT-KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 EI+ + Y+ K+ D+WS+G +L +L R F H D L S + CI Sbjct: 172 EILNTTGTYSGKAADVWSLGVMLYTLLVGRYPF---HDSDP-----SALFSKIRRGQFCI 223 Query: 273 ---INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY 329 I+ KAR ++SL L P++R+T E L HP+ Sbjct: 224 PEHISPKARCLIRSL--------------------------LRREPSERLTAPEILLHPW 257 Query: 330 LEQ 332 E Sbjct: 258 FES 260 >2CMW-A nrPDB Length = 310 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 23/52 (44%), Positives = 33/52 (63%), Gaps = 6/52 (11%) Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLK-----ICDFGLAR-IADPE 194 Q+L ++Y+HS N+++RD+KP N LI + K I DFGLA+ DPE Sbjct: 105 QLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPE 156 >2RSV-A nrPDB Length = 403 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 42/171 (24%), Positives = 76/171 (44%), Gaps = 18/171 (10%) Query: 48 IGEGAYGMV----SSAYDHVRKTRVAIKKISP------FEHQTYCQRTLR--EIQILLRF 95 IG+G +G + ++ + V + K+ P F + QR + +IQ +R Sbjct: 50 IGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRT 109 Query: 96 RHENVIGIRDILRASTLEAMRDVY--IVQDLMETDLYKLLKS--QQLSNDHICYFLYQIL 151 R +G+ + + Y ++ D +DL K+ ++ ++ S + +IL Sbjct: 110 RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRIL 169 Query: 152 RGLKYIHSANVLHRDLKPSNLLIN--TTCDLKICDFGLARIADPEHDHTGF 200 L+YIH +H D+K SNLL+N + + D+GLA PE H + Sbjct: 170 DILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 220 >4NT4-A nrPDB Length = 312 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 42/160 (26%), Positives = 72/160 (45%), Gaps = 10/160 (6%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 VGP + + IG G +G + + VAIK + P + + LL Sbjct: 10 VGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIK-MEPMKSKAPQLHLEYRFYKLLGSHA 68 Query: 98 ENV-IGIRDILRASTLEAMRDVYIVQ--DLMETDLYKLLKSQQLSNDHICYFLYQILRGL 154 +N GI I T + +++ L DL+ + +++ S + Q+L + Sbjct: 69 DNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNIC-ARKFSLKTVLMIAKQLLHRI 127 Query: 155 KYIHSANVLHRDLKPSNLLINTTCD-----LKICDFGLAR 189 +Y+HS ++++RD+KP N LI T + I DFGLA+ Sbjct: 128 EYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAK 167 >5OAT-A nrPDB Length = 411 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 43/149 (28%), Positives = 68/149 (45%), Gaps = 17/149 (11%) Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCD----LKICDFGLARIADPEHD----HTGFLTEY 204 G+ ++ + + HRDLK NLL++T+ L I DFG +AD + +T + + Sbjct: 165 GVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCC-LADKTNGLSLPYTSYEMDK 223 Query: 205 VATRWYRAPEIMLNSKG------YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL 258 APEI+ G Y+K+ D+W+VG I E+ + F G L N+ Sbjct: 224 GGNTALMAPEIICQKPGTFSVLNYSKA-DLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKE 282 Query: 259 GILGSPSQEDLNCIINMKARNYLQSLPSK 287 G L E + +I N L+ P+K Sbjct: 283 GDLPKLPDE-VPTVIQALVANLLKRNPNK 310 >6DC0-A nrPDB Length = 292 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 56/243 (23%), Positives = 98/243 (40%), Gaps = 49/243 (20%) Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGLK 155 H N+ GI +++ T Y+ + D++ ++S++ L + QI+ + Sbjct: 57 HSNITGIVEVILGET-----KAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVA 111 Query: 156 YIHSANVLHRDLKPSNLLINTT--CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 + H + ++ DLK + +T L++ I E D L++ Y +P Sbjct: 112 HCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDD---ALSDKHGCPAYVSP 168 Query: 214 EIMLNSKGYT-KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 EI+ + Y+ K+ D+WS+G +L +L R F H D L S + CI Sbjct: 169 EILNTTGTYSGKAADVWSLGVMLYTLLVGRYPF---HDSDP-----SALFSKIRRGQFCI 220 Query: 273 ---INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY 329 I+ KAR ++SL L P++R+T E L HP+ Sbjct: 221 PEHISPKARCLIRSL--------------------------LRREPSERLTAPEILLHPW 254 Query: 330 LEQ 332 E Sbjct: 255 FES 257 >1CSN-A nrPDB Length = 298 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 42/171 (24%), Positives = 76/171 (44%), Gaps = 15/171 (8%) Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQ 90 + GQ VG Y + IGEG++G++ + + +VAIK + R + Sbjct: 1 MSGQNNVVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYK 60 Query: 91 ILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLY 148 +L GI ++ E + +V ++ DL+ L LL ++ S + Sbjct: 61 LL-----AGCTGIPNVYYFGQ-EGLHNVLVI-DLLGPSLEDLLDLCGRKFSVKTVAMAAK 113 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLIN-----TTCDLKICDFGLARI-ADP 193 Q+L ++ IH ++++RD+KP N LI + + DFG+ + DP Sbjct: 114 QMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDP 164 >2CHL-A nrPDB Length = 351 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 46/167 (27%), Positives = 73/167 (43%), Gaps = 19/167 (11%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 VGP + + IG G +G + + VAIK + P + R Q+ L +R Sbjct: 28 VGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKS--------RAPQLHLEYRF 78 Query: 98 ENVIGIRDILRASTLEAMRDVY--IVQDLMETDLYKL--LKSQQLSNDHICYFLYQILRG 153 +G D + Y +V +L+ L L L + S + Q++ Sbjct: 79 YKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISR 138 Query: 154 LKYIHSANVLHRDLKPSNLLI-----NTTCDLKICDFGLAR-IADPE 194 ++Y+HS N+++RD+KP N LI T + I DF LA+ DPE Sbjct: 139 MEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPE 185 >4JRN-A nrPDB Length = 372 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 25/93 (26%), Positives = 41/93 (44%), Gaps = 9/93 (9%) Query: 145 YFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEY 204 Y Q ++ + + + ++H D+KP+N L+ L + DFG RI + + Sbjct: 206 YLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINNS-------VGRA 258 Query: 205 VATRWYRAPEIMLNSKG--YTKSIDIWSVGCIL 235 + T Y PE + G YT D W +G L Sbjct: 259 IGTPGYEPPERPFQATGITYTFPTDAWQLGITL 291 >5X18-A nrPDB Length = 295 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 38/162 (23%), Positives = 77/162 (47%), Gaps = 20/162 (12%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 VG Y + IGEG++G++ + + VAIK FE + LR+ ++ Sbjct: 5 VGLHYKIGKKIGEGSFGVLFEGTNMINGVPVAIK----FEPRKTEAPQLRD-----EYKT 55 Query: 98 ENVI-GIRDILRASTL--EAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILR 152 ++ G +I A E + ++ ++ DL+ L L ++ S + Q++ Sbjct: 56 YKILNGTPNIPYAYYFGQEGLHNILVI-DLLGPSLEDLFDWCGRKFSVKTVVQVAVQMIT 114 Query: 153 GLKYIHSANVLHRDLKPSNLLIN-----TTCDLKICDFGLAR 189 ++ +H+ ++++RD+KP N LI ++ + DFG+A+ Sbjct: 115 LIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAK 156 >4M69-B nrPDB Length = 283 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 36/163 (22%), Positives = 73/163 (44%), Gaps = 3/163 (1%) Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL-KSQQLSNDHICYF 146 EI+ + +F N++ I I T++ +++ L +LL + + L+ Sbjct: 58 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLL 117 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADP-EHDHTGFLTEYV 205 + + RGL +H + LHR++ S+ L+ +K+ F L++ + E Sbjct: 118 VLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERS 177 Query: 206 ATRWYRAPEIMLNSKG-YTKSIDIWSVGCILAEMLSNRPIFPG 247 ++ Y +PE + N Y +I+S G +L E+ + + F G Sbjct: 178 SSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEG 220 >4IX6-A nrPDB Length = 350 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 43/211 (20%), Positives = 78/211 (36%), Gaps = 46/211 (21%) Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLI--NTTCDLKICDFGLARIADPEHDHTGFL--T 202 + ++L L +H V+HRD+KP+NL+ LK+ D G A + P + + Sbjct: 149 MRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETLNYYPGD 208 Query: 203 EYVATRWYRAPEIMLNSKGYTK----------------SIDIWSVGCILAEM--LSNRPI 244 R+ +A E+ L G + D WS GC++ ++ + R Sbjct: 209 GPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLAVVGLRTD 268 Query: 245 FPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNY----LQSLPSKTKVAWAKLFPKSD 300 + +L + D+N K+ Y +L + W Sbjct: 269 AGLERFLADYKAV--------GYDVNAFRGEKSGEYGTMDFAALDANGGAGW-------- 312 Query: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 DL R++ + R + E AL+H + + Sbjct: 313 ----DLCQRLMEAERDARASCEAALSHAFFD 339 >5VDK-A nrPDB Length = 297 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 35/142 (24%), Positives = 62/142 (43%), Gaps = 13/142 (9%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKK-ISPFEHQTYCQRTLREIQILLRFRHEN 99 + +++ IG G +G V + AIK+ + F + L E+ + H Sbjct: 16 EFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEV-----YAHAV 70 Query: 100 VIGIRDILRASTLEAMRDVYIVQD--LMETDLYKLLKSQQLSNDH-----ICYFLYQILR 152 + ++R + A D I+Q+ L + S +H + L QI Sbjct: 71 LGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISL 130 Query: 153 GLKYIHSANVLHRDLKPSNLLI 174 GL YIH+++++H D+KPSN+ I Sbjct: 131 GLNYIHNSSMVHLDIKPSNIFI 152 >2C47-A nrPDB Length = 313 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 18/52 (34%), Positives = 32/52 (61%), Gaps = 6/52 (11%) Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCD-----LKICDFGLAR-IADPE 194 Q++ ++Y+H+ ++++RD+KP N L+ + I DFGLA+ DPE Sbjct: 108 QLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPE 159 >4BTF-A nrPDB Length = 469 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 36/163 (22%), Positives = 73/163 (44%), Gaps = 3/163 (1%) Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL-KSQQLSNDHICYF 146 EI+ + +F N++ I I T++ +++ L +LL + + L+ Sbjct: 244 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLL 303 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADP-EHDHTGFLTEYV 205 + + RGL +H + LHR++ S+ L+ +K+ F L++ + E Sbjct: 304 VLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERS 363 Query: 206 ATRWYRAPEIMLNSKG-YTKSIDIWSVGCILAEMLSNRPIFPG 247 ++ Y +PE + N Y +I+S G +L E+ + + F G Sbjct: 364 SSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEG 406 >3ENH-A nrPDB Length = 540 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 32/106 (30%), Positives = 48/106 (45%), Gaps = 10/106 (9%) Query: 131 KLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARI 190 KL K N I Y + +I+ L H +V+H DL SN + + DL I DFGL +I Sbjct: 424 KLAKDVIEDNLDIAYKIGEIVGKL---HKNDVIHNDLTTSNFIFDK--DLYIIDFGLGKI 478 Query: 191 ADPEHDHT----GFLTEYVATRWYRAPEIMLNS-KGYTKSIDIWSV 231 ++ + D F ++T + EI +GY D W + Sbjct: 479 SNLDEDKAVDLIVFKKAVLSTHHEKFDEIWERFLEGYKSVYDRWEI 524 >5M07-A nrPDB Length = 276 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 36/162 (22%), Positives = 65/162 (40%), Gaps = 25/162 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF--EHQTYCQRTLREIQILLRFRHEN 99 YT ++ +G A G V A+K +SP + +R RE ++ R H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSND---------HICYFLYQI 150 ++ + D R + Q + D + + Q D + + + Sbjct: 92 ILEVHD----------RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAV 141 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTC--DLKI--CDFGLA 188 L Y H +LHRD+ P+N+++ + D +I DFG+A Sbjct: 142 AGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIA 183 >4XHL-A nrPDB Length = 394 Score = 36.2 bits (82), Expect = 0.025, Method: Compositional matrix adjust. Identities = 39/160 (24%), Positives = 66/160 (41%), Gaps = 18/160 (11%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQ---TYCQRTLREIQILLR 94 VG ++ + IG G++G + + + VAI+ S Y R R + + Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSGGV- 63 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILR 152 + IR R AM V DL+ L L ++ S + Q+ Sbjct: 64 ----GIPFIRWFGREGEYNAM-----VIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFC 114 Query: 153 GLKYIHSANVLHRDLKPSNLLINT---TCDLKICDFGLAR 189 ++YIH + +HRD+KP N L+ + + DFGL++ Sbjct: 115 RIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSK 154 >5CLR-A nrPDB Length = 451 Score = 35.8 bits (81), Expect = 0.031, Method: Compositional matrix adjust. Identities = 24/98 (24%), Positives = 48/98 (48%), Gaps = 12/98 (12%) Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 + + +K H ++HRDLKP N++++ + DFG + +D E + Sbjct: 182 MISVCHQVKQFHELGLIHRDLKPGNIMLDADMQCHLVDFG-SSSSDKEPKPASW-----G 235 Query: 207 TRWYRAPEIMLNSK----GYTKSIDIWSVGCILAEMLS 240 T Y APE LN++ +++ D++++ L E+ + Sbjct: 236 TASYLAPE--LNAQEDFIAFSQVSDLFALAYSLDELFN 271 >4XHH-A nrPDB Length = 403 Score = 35.8 bits (81), Expect = 0.034, Method: Compositional matrix adjust. Identities = 39/160 (24%), Positives = 66/160 (41%), Gaps = 18/160 (11%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 VG ++ + IG G++G + + + VAI+ S R + L Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKYL----- 59 Query: 98 ENVIGI---RDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILR 152 +GI R R AM V DL+ L L ++ S + Q++ Sbjct: 60 SGGVGIPFIRWFGREGEYNAM-----VIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMIC 114 Query: 153 GLKYIHSANVLHRDLKPSNLLINT---TCDLKICDFGLAR 189 ++YIH + +HRD+KP N L+ + + DFGL++ Sbjct: 115 RVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSK 154 >4L00-A nrPDB Length = 304 Score = 35.4 bits (80), Expect = 0.042, Method: Compositional matrix adjust. Identities = 44/193 (22%), Positives = 83/193 (43%), Gaps = 27/193 (13%) Query: 64 RKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDV--YIV 121 +K +V +K + P H+ ++ + H++++ + + +RDV +V Sbjct: 59 KKIKVILKVLDP-SHRDISLAFFEAASMMRQVSHKHIVYLYGV-------CVRDVENIMV 110 Query: 122 QDLME---TDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL----- 173 ++ +E DL+ KS L+ Q+ L Y+ +++H ++ NLL Sbjct: 111 EEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREG 170 Query: 174 INTTCDLKICDFGLARIADPEHDHTGFLTEYVATR--WYRAPEIMLNSKGYTKSIDIWSV 231 I++ C I +++DP T + R W APE + +SK + + D WS Sbjct: 171 IDSECGPFI------KLSDPGIPITVLSRQECIERIPWI-APECVEDSKNLSVAADKWSF 223 Query: 232 GCILAEMLSNRPI 244 G L E+ N I Sbjct: 224 GTTLWEICYNGEI 236 >5UU1-A nrPDB Length = 324 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 37/178 (20%), Positives = 78/178 (43%), Gaps = 17/178 (9%) Query: 39 GPRYTQLQYIGEGAYGMVSSAY-------DHVRKTRVAIKKISP-FEHQTYCQRTLRE-- 88 G ++ + IG G +G++ A+ D +V ++ P F + QR ++ Sbjct: 15 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDC 74 Query: 89 IQILLRFRHENVIGIRDILRASTLEAMRDV---YIVQDLMETDLYKLL-KSQQLSNDHIC 144 I+ + + + +GI + S L + ++V + + DL K+ ++ + Sbjct: 75 IKKWIERKQLDYLGI-PLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVL 133 Query: 145 YFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC--DLKICDFGLARIADPEHDHTGF 200 ++L L+YIH +H D+K +NLL+ + + D+GL+ P +H + Sbjct: 134 QLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQY 191 >5VE6-A nrPDB Length = 492 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 12/32 (37%), Positives = 21/32 (65%) Query: 143 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLI 174 +C+ L Q+ GL+++ ++HRDL NLL+ Sbjct: 210 VCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 >6EWX-A nrPDB Length = 484 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 12/32 (37%), Positives = 21/32 (65%) Query: 143 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLI 174 +C+ L Q+ GL+++ ++HRDL NLL+ Sbjct: 212 VCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 243 >2XHY-A nrPDB Length = 479 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 30/130 (23%), Positives = 54/130 (41%), Gaps = 19/130 (14%) Query: 242 RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDS 301 + + PGK+Y NH +ED+ M + + +T +AW ++FPK D Sbjct: 53 KEVLPGKYYP---NHEAVDFYGHYKEDIKLFAEMGFKCF------RTSIAWTRIFPKGDE 103 Query: 302 KAL---------DLLDRMLTFNPNKRITVEE-ALAHPYLEQYYDPTDEPVAEEPFTFAME 351 D+ D +L +N IT+ + ++QY T+ V + FA Sbjct: 104 AQPNEEGLKFYDDMFDELLKYNIEPVITLSHFEMPLHLVQQYGSWTNRKVVDFFVRFAEV 163 Query: 352 LDDLPKERLK 361 + + K ++K Sbjct: 164 VFERYKHKVK 173 >4CI6-B nrPDB Length = 643 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 21/94 (22%), Positives = 47/94 (50%), Gaps = 9/94 (9%) Query: 143 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN-TTCDLKICDFGLARIADPEHDHTGFL 201 I + +++L ++ A ++H D+KP N++ + + + + D GL H +G Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGL-------HSRSGEQ 210 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL 235 + T ++APE+ + + G ++ D++ V L Sbjct: 211 PKGF-TESFKAPELGVGNLGASEKSDVFLVVSTL 243 >6EQI-C nrPDB Length = 433 Score = 32.3 bits (72), Expect = 0.35, Method: Compositional matrix adjust. Identities = 31/107 (28%), Positives = 51/107 (47%), Gaps = 25/107 (23%) Query: 153 GLKYIHSANVLHRDLKPSNLLINTT-----CDLKICDFGLARIADPEHDHTGFLTEYVA- 206 + +++ N+ HRDLK N+L++ + + I DFG + D ++ G + Y + Sbjct: 179 AVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCC-LCDKQN---GLVIPYRSE 234 Query: 207 ------TRWYRAPEIMLNSK-------GYTKSIDIWSVGCILAEMLS 240 R APEI N+K Y KS D+W+VG I E+ + Sbjct: 235 DQDKGGNRALMAPEIA-NAKPGTFSWLNYKKS-DLWAVGAIAYEIFN 279 >4OAU-C nrPDB Length = 699 Score = 32.3 bits (72), Expect = 0.39, Method: Compositional matrix adjust. Identities = 51/214 (23%), Positives = 87/214 (40%), Gaps = 36/214 (16%) Query: 65 KTRVAIKKI---SP-FEHQTYCQRTLREIQILLRF----RHENVIGIRDILRASTLEAMR 116 K VA+K SP + + C ++ RE L+ F H + + L TLEA Sbjct: 366 KQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACL 425 Query: 117 DVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH-SANVLHRDLKPSNLLIN 175 DV+ +D+ + ++ L I + ++ +H S H+DL+P N+LI+ Sbjct: 426 DVHRGEDV-----------ENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID 474 Query: 176 TTCDLKICDF--GLARIADPEH-----DHTGFLTEYVATRW---YRAPEIMLNSKGYTKS 225 + + DF + DP+ + G L YV + + + N + S Sbjct: 475 SKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS 534 Query: 226 IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 259 D + I +R PG+H D L+ +LG Sbjct: 535 PDEETKDLI------HRLFHPGEHVRDCLSDLLG 562 >6J6I-B nrPDB Length = 351 Score = 31.6 bits (70), Expect = 0.63, Method: Compositional matrix adjust. Identities = 22/98 (22%), Positives = 48/98 (48%), Gaps = 5/98 (5%) Query: 149 QILRGLKYIHSAN---VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYV 205 +I + Y+H+A ++HRD+KP ++ ++ K+ D + I+ PE + E+V Sbjct: 171 EIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFS-ISLPE-GKSRIEAEWV 228 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRP 243 + + + T+ D++S G L +++ +P Sbjct: 229 LGTFGYIDPLYHKTCFVTEYTDVYSFGICLLVIITGKP 266 >5USZ-A nrPDB Length = 289 Score = 31.2 bits (69), Expect = 0.85, Method: Compositional matrix adjust. Identities = 36/209 (17%), Positives = 83/209 (39%), Gaps = 23/209 (11%) Query: 46 QYIGEGAYGMVSSA-------YDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 + +G+G + + Y + +T V +K + H+ Y + ++ + H+ Sbjct: 14 ESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDK-AHRNYSESFFEAASMMSKLSHK 72 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY------QILR 152 +++ L + +VQ+ ++ + L + N + L+ Q+ Sbjct: 73 HLV-----LNYGVCVCGDENILVQEFVK---FGSLDTYLKKNKNCINILWKLEVAKQLAA 124 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW-YR 211 + ++ ++H ++ N+L+ D K + +++DP T + + R + Sbjct: 125 AMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWV 184 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLS 240 PE + N K + D WS G L E+ S Sbjct: 185 PPECIENPKNLNLATDKWSFGTTLWEICS 213 >2R1H-A nrPDB Length = 143 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 19/71 (26%), Positives = 26/71 (36%), Gaps = 11/71 (15%) Query: 286 SKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD--PTDEPVAE 343 + K W K+ PKSD L RML P + Y + P PV + Sbjct: 9 ANVKAIWGKILPKSDEIGEQALSRMLVVYPQTK---------AYFSHWASVAPGSAPVKK 59 Query: 344 EPFTFAMELDD 354 T ++DD Sbjct: 60 HGITIMNQIDD 70 >4O1O-A nrPDB Length = 717 Score = 29.3 bits (64), Expect = 2.8, Method: Compositional matrix adjust. Identities = 11/40 (27%), Positives = 22/40 (55%) Query: 146 FLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDF 185 L + + + +H + H+DL+P N+LI++ + DF Sbjct: 447 ILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF 486 >5DMZ-A nrPDB Length = 365 Score = 28.9 bits (63), Expect = 3.8, Method: Compositional matrix adjust. Identities = 27/127 (21%), Positives = 51/127 (40%), Gaps = 13/127 (10%) Query: 124 LMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLI--------- 174 L +LYK + + + F ++L ++ +H ++H D+KP N ++ Sbjct: 155 LNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDD 214 Query: 175 --NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVG 232 + + L + D G I T T ++ E ML++K + ID + V Sbjct: 215 EDDLSAGLALIDLG-QSIDMKLFPKGTIFTAKCETSGFQCVE-MLSNKPWNYQIDYFGVA 272 Query: 233 CILAEML 239 + ML Sbjct: 273 ATVYCML 279 >3BCQ-A nrPDB Length = 142 Score = 28.5 bits (62), Expect = 4.6, Method: Compositional matrix adjust. Identities = 13/30 (43%), Positives = 17/30 (56%) Query: 289 KVAWAKLFPKSDSKALDLLDRMLTFNPNKR 318 K WAK+ PK++ D L RMLT P + Sbjct: 11 KAFWAKISPKAEDIGADALARMLTVYPQTK 40 >5LC5-m nrPDB Length = 118 Score = 28.1 bits (61), Expect = 6.0, Method: Compositional matrix adjust. Identities = 15/47 (31%), Positives = 23/47 (48%), Gaps = 4/47 (8%) Query: 317 KRITVEEALAHPYLEQYYDPTDEPVAEEP----FTFAMELDDLPKER 359 +R+ + L Y QYYDP+ V E+P +T+A + P R Sbjct: 24 ERLAIRSRLKREYQLQYYDPSRRGVIEDPALVRWTYARSANIYPNFR 70 >6BHC-A nrPDB Length = 438 Score = 27.7 bits (60), Expect = 9.5, Method: Compositional matrix adjust. Identities = 18/54 (33%), Positives = 28/54 (51%) Query: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLI 174 V D + L + KS L +C L Q+ GL+++ +V H DL+ NLL+ Sbjct: 158 VADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLL 211 >3K57-A nrPDB Length = 786 Score = 27.7 bits (60), Expect = 9.6, Method: Compositional matrix adjust. Identities = 21/72 (29%), Positives = 32/72 (44%), Gaps = 12/72 (16%) Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 251 DPEH GFL + + + PEI+ N IW G A+ N+P+ + Sbjct: 449 DPEHSTEGFLDAWFSREKHCLPEIVTN---------IWH-GRDEAKRQGNKPLSQALKII 498 Query: 252 DQLNHILGILGS 263 +N G+LG+ Sbjct: 499 --MNAFYGVLGT 508 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4QTB-A nrPDB 558 e-159 5NGU-A nrPDB 483 e-137 4EWQ-A nrPDB 397 e-111 3OHT-A nrPDB 392 e-109 4IC8-A nrPDB 385 e-107 2F9G-A nrPDB 385 e-107 4ZSG-A nrPDB 383 e-107 5Z33-A nrPDB 381 e-106 3GC9-A nrPDB 380 e-106 6DTL-A nrPDB 374 e-104 1CM8-A nrPDB 374 e-104 4MYG-A nrPDB 373 e-104 4QNY-A nrPDB 349 1e-96 1JNK-A nrPDB 348 3e-96 5AWM-A nrPDB 346 6e-96 3E7O-A nrPDB 345 1e-95 3OZ6-A nrPDB 343 8e-95 2XS0-A nrPDB 341 2e-94 3RP9-A nrPDB 335 2e-92 4O2Z-A nrPDB 333 8e-92 3FI2-A nrPDB 330 5e-91 2BPM-A nrPDB 330 7e-91 3N9X-A nrPDB 324 3e-89 3NIE-A nrPDB 319 1e-87 3NIZ-A nrPDB 315 2e-86 3PG1-A nrPDB 311 5e-85 2I6L-A nrPDB 308 4e-84 6GU6-A nrPDB 307 6e-84 4AU8-A nrPDB 304 4e-83 4KRC-A nrPDB 304 5e-83 1V0B-A nrPDB 301 3e-82 5EFQ-A nrPDB 299 9e-82 5JN2-A nrPDB 298 3e-81 4NST-A nrPDB 294 3e-80 1UA2-A nrPDB 294 5e-80 1G3N-A nrPDB 293 7e-80 3NCG-A nrPDB 293 1e-79 3MIA-A nrPDB 290 6e-79 4BBM-A nrPDB 290 8e-79 3DFA-A nrPDB 289 1e-78 4AGU-A nrPDB 287 7e-78 3MA6-A nrPDB 286 1e-77 5G6V-A nrPDB 283 7e-77 3HZT-A nrPDB 283 1e-76 4MVF-A nrPDB 283 1e-76 5AIR-A nrPDB 282 2e-76 2W96-B nrPDB 281 3e-76 3DXN-A nrPDB 278 3e-75 3LIJ-A nrPDB 277 7e-75 3GC0-A nrPDB 274 4e-74 3ZDU-A nrPDB 272 1e-73 4RGJ-A nrPDB 272 1e-73 4BGQ-A nrPDB 272 2e-73 4E7W-A nrPDB 271 5e-73 3Q5I-A nrPDB 271 5e-73 2BDW-A nrPDB 267 5e-72 5FG8-A nrPDB 267 5e-72 4YZB-A nrPDB 266 1e-71 3MN3-A nrPDB 265 2e-71 4REW-A nrPDB 264 3e-71 2VN9-A nrPDB 264 4e-71 4FG9-A nrPDB 263 7e-71 3E3P-A nrPDB 262 1e-70 2JC6-A nrPDB 262 1e-70 3H4J-B nrPDB 262 2e-70 4CQG-A nrPDB 261 3e-70 3KK8-A nrPDB 261 4e-70 2V7O-A nrPDB 261 4e-70 5YKS-A nrPDB 261 5e-70 5U6Y-A nrPDB 261 5e-70 5ES1-A nrPDB 260 6e-70 4CFH-A nrPDB 260 9e-70 3BHH-A nrPDB 260 9e-70 4D2V-A nrPDB 260 9e-70 4RED-A nrPDB 259 1e-69 2QNJ-A nrPDB 259 1e-69 2VZ6-A nrPDB 259 2e-69 5Y86-A nrPDB 259 2e-69 5IG1-A nrPDB 259 2e-69 4CFF-A nrPDB 257 4e-69 4D28-A nrPDB 257 5e-69 5EZV-A nrPDB 257 6e-69 5ZTN-A nrPDB 256 1e-68 2JAM-A nrPDB 255 2e-68 3EB0-A nrPDB 255 3e-68 5KZ7-A nrPDB 254 4e-68 4CZT-A nrPDB 254 5e-68 2YCR-A nrPDB 254 6e-68 3SOA-A nrPDB 253 7e-68 5WAX-A nrPDB 253 7e-68 3COM-A nrPDB 253 1e-67 3I6U-A nrPDB 251 3e-67 4NIF-A nrPDB 251 3e-67 6FD3-A nrPDB 251 4e-67 1PHK-A nrPDB 251 5e-67 3DAK-A nrPDB 251 5e-67 5KCV-A nrPDB 250 8e-67 5XZW-A nrPDB 250 1e-66 2Y7J-A nrPDB 249 1e-66 1U5R-A nrPDB 249 1e-66 3F3Z-A nrPDB 249 2e-66 4B6L-A nrPDB 249 2e-66 2GCD-A nrPDB 248 3e-66 4JG6-A nrPDB 247 5e-66 2YZA-A nrPDB 247 5e-66 2YAB-A nrPDB 247 6e-66 2J90-A nrPDB 247 7e-66 3GUB-A nrPDB 246 1e-65 5DBX-A nrPDB 246 1e-65 4LG4-A nrPDB 246 1e-65 2F57-A nrPDB 245 3e-65 2HW6-A nrPDB 244 4e-65 2W4O-A nrPDB 244 4e-65 6AO5-A nrPDB 244 6e-65 3ZUT-A nrPDB 243 8e-65 3IS5-A nrPDB 243 1e-64 4L42-A nrPDB 243 1e-64 4CRL-A nrPDB 243 1e-64 6CMJ-A nrPDB 242 1e-64 4FIE-A nrPDB 242 2e-64 4JXF-A nrPDB 242 2e-64 5JZN-A nrPDB 242 2e-64 4XBR-A nrPDB 242 2e-64 2Q0N-A nrPDB 242 2e-64 2A27-A nrPDB 242 2e-64 4I6B-A nrPDB 242 3e-64 4PDS-A nrPDB 241 3e-64 2X4F-A nrPDB 241 3e-64 3Q53-A nrPDB 241 3e-64 4JDH-A nrPDB 241 3e-64 4KS7-A nrPDB 241 5e-64 6O6Q-A nrPDB 241 5e-64 3UC3-A nrPDB 241 5e-64 3UDB-A nrPDB 241 6e-64 6CKI-A nrPDB 241 6e-64 4YNZ-A nrPDB 240 6e-64 3TAC-A nrPDB 240 7e-64 3D2K-A nrPDB 240 9e-64 6C9D-A nrPDB 239 1e-63 1ZWS-A nrPDB 239 1e-63 6FDY-U nrPDB 239 1e-63 4UZD-A nrPDB 239 2e-63 2Z7Q-A nrPDB 239 2e-63 2HAK-A nrPDB 239 2e-63 4QMW-A nrPDB 238 3e-63 5D7A-A nrPDB 238 3e-63 5D9K-A nrPDB 237 5e-63 2UV2-A nrPDB 237 5e-63 4RLP-A nrPDB 235 2e-62 5YV8-A nrPDB 235 3e-62 2XIK-A nrPDB 235 3e-62 3DB8-A nrPDB 235 3e-62 1FOT-A nrPDB 234 4e-62 3UTO-A nrPDB 233 1e-61 4FZF-B nrPDB 232 2e-61 2OU7-A nrPDB 232 2e-61 5J5T-A nrPDB 232 2e-61 4J52-A nrPDB 232 3e-61 3KN6-A nrPDB 231 4e-61 2JDO-A nrPDB 231 4e-61 1KOA-A nrPDB 231 4e-61 3MV5-A nrPDB 231 5e-61 2WO6-A nrPDB 231 5e-61 1VZO-A nrPDB 230 8e-61 3HDN-A nrPDB 229 1e-60 4WNO-A nrPDB 229 2e-60 5X8I-B nrPDB 229 2e-60 1KOB-A nrPDB 229 2e-60 2OZA-A nrPDB 227 4e-60 3HKO-A nrPDB 227 6e-60 5DYK-A nrPDB 226 9e-60 6FYV-A nrPDB 226 1e-59 1NY3-A nrPDB 226 1e-59 5X3F-B nrPDB 225 2e-59 6CQF-A nrPDB 225 3e-59 3ORZ-A nrPDB 225 3e-59 3KA0-A nrPDB 225 3e-59 6E9W-A nrPDB 225 3e-59 2BRG-A nrPDB 224 4e-59 5XVU-A nrPDB 223 1e-58 3FXW-A nrPDB 223 1e-58 6ED6-A nrPDB 222 1e-58 4WB7-A nrPDB 222 2e-58 6HXF-B nrPDB 222 2e-58 3TXO-A nrPDB 222 2e-58 2WTK-C nrPDB 222 2e-58 4U41-A nrPDB 222 2e-58 4CSV-A nrPDB 222 2e-58 6QAU-A nrPDB 222 2e-58 5N23-A nrPDB 222 2e-58 5F9E-A nrPDB 221 3e-58 5FET-A nrPDB 221 3e-58 4B8L-A nrPDB 220 7e-58 4C0T-A nrPDB 219 2e-57 4MD7-E nrPDB 218 3e-57 4APC-A nrPDB 217 6e-57 6CCF-A nrPDB 217 6e-57 5LOH-A nrPDB 216 1e-56 3LM0-A nrPDB 216 1e-56 2PVN-A nrPDB 216 1e-56 4XEY-B nrPDB 215 2e-56 6HMD-A nrPDB 215 2e-56 2FO0-A nrPDB 215 2e-56 6EII-A nrPDB 215 2e-56 4GS6-A nrPDB 215 2e-56 2H8H-A nrPDB 215 3e-56 6F3F-A nrPDB 214 5e-56 3A8W-A nrPDB 214 5e-56 6DBM-A nrPDB 213 1e-55 4OLI-A nrPDB 213 1e-55 4AF3-A nrPDB 213 1e-55 3RAW-A nrPDB 213 1e-55 5MJB-A nrPDB 213 1e-55 4RA4-A nrPDB 211 3e-55 4AW2-A nrPDB 211 4e-55 6E2O-A nrPDB 211 4e-55 4E20-A nrPDB 211 5e-55 4FR4-A nrPDB 210 9e-55 6BSD-A nrPDB 210 9e-55 6DBN-A nrPDB 210 9e-55 5L6P-A nrPDB 210 1e-54 3TKU-A nrPDB 209 1e-54 5TQX-A nrPDB 209 1e-54 6GQK-A nrPDB 209 2e-54 5A46-A nrPDB 209 2e-54 5SYS-A nrPDB 209 2e-54 1JPA-A nrPDB 209 3e-54 2WQN-A nrPDB 208 3e-54 2VWV-A nrPDB 207 6e-54 3TT0-A nrPDB 207 6e-54 3ALO-A nrPDB 206 1e-53 4EBW-A nrPDB 206 1e-53 1TKI-A nrPDB 206 2e-53 4KIK-B nrPDB 205 2e-53 3GQL-A nrPDB 205 2e-53 3VN9-A nrPDB 205 2e-53 6BDL-A nrPDB 205 2e-53 2DQ7-X nrPDB 205 3e-53 5UNP-A nrPDB 205 3e-53 3NYO-A nrPDB 204 4e-53 6NPU-A nrPDB 204 5e-53 2J0K-A nrPDB 204 5e-53 3PFQ-A nrPDB 204 7e-53 2Y6O-A nrPDB 204 8e-53 2PSQ-A nrPDB 203 1e-52 1ZXE-A nrPDB 203 1e-52 3ORP-A nrPDB 202 1e-52 4P5Q-A nrPDB 202 2e-52 4K33-A nrPDB 202 2e-52 4E93-A nrPDB 202 2e-52 3FME-A nrPDB 202 3e-52 5HI2-A nrPDB 202 3e-52 3PPZ-A nrPDB 201 4e-52 2XNP-A nrPDB 200 5e-52 2R2P-A nrPDB 200 5e-52 6GVJ-A nrPDB 200 6e-52 5KMM-A nrPDB 200 6e-52 4TNB-A nrPDB 200 6e-52 3M42-A nrPDB 200 6e-52 3QA8-A nrPDB 200 6e-52 2XYN-A nrPDB 200 7e-52 3DKO-A nrPDB 200 8e-52 4EQM-A nrPDB 200 9e-52 5HIE-A nrPDB 200 9e-52 4LFI-A nrPDB 200 1e-51 5O2B-A nrPDB 199 2e-51 5EG3-A nrPDB 199 2e-51 4UY9-A nrPDB 199 2e-51 3A4O-X nrPDB 199 2e-51 2I0E-A nrPDB 199 2e-51 6FEX-A nrPDB 198 3e-51 5O2C-A nrPDB 198 4e-51 4PDO-A nrPDB 197 5e-51 5X5O-A nrPDB 197 6e-51 4PWN-A nrPDB 197 8e-51 3HMP-A nrPDB 197 8e-51 4XCU-A nrPDB 197 9e-51 3V5Q-A nrPDB 197 9e-51 5H2U-A nrPDB 197 1e-50 3OMV-A nrPDB 196 1e-50 5X02-A nrPDB 196 1e-50 4AT3-A nrPDB 196 1e-50 2OGV-A nrPDB 196 2e-50 3CJF-A nrPDB 196 2e-50 4IAN-A nrPDB 196 2e-50 3G0E-A nrPDB 195 2e-50 2X7G-A nrPDB 195 2e-50 5AP3-A nrPDB 195 2e-50 1LUF-A nrPDB 195 2e-50 2VD5-A nrPDB 195 2e-50 3BBT-B nrPDB 195 2e-50 4XUF-A nrPDB 195 3e-50 5KKR-C nrPDB 195 3e-50 4AN9-A nrPDB 195 3e-50 3LZB-A nrPDB 195 3e-50 3DTC-A nrPDB 195 3e-50 3BEA-A nrPDB 195 3e-50 2JD5-A nrPDB 195 4e-50 5GNK-A nrPDB 194 6e-50 3DLS-A nrPDB 194 6e-50 4UYA-A nrPDB 194 6e-50 3KRL-A nrPDB 194 6e-50 2HK5-A nrPDB 194 6e-50 6BXI-A nrPDB 194 7e-50 4XLV-A nrPDB 194 7e-50 2ZMD-A nrPDB 194 8e-50 5O0Y-A nrPDB 194 8e-50 3EQC-A nrPDB 193 1e-49 5VO2-A nrPDB 193 1e-49 4H1J-A nrPDB 193 1e-49 5HLW-A nrPDB 192 2e-49 5TOS-A nrPDB 192 2e-49 3KUL-B nrPDB 192 2e-49 3QGY-A nrPDB 192 2e-49 5AMN-A nrPDB 192 2e-49 5UUU-A nrPDB 192 3e-49 2W1I-A nrPDB 192 3e-49 3IO7-A nrPDB 192 3e-49 3C51-A nrPDB 192 3e-49 2PL0-A nrPDB 192 3e-49 3PVW-A nrPDB 191 3e-49 3C1X-A nrPDB 191 4e-49 6B2Q-A nrPDB 190 7e-49 3PP0-A nrPDB 190 7e-49 5UIU-A nrPDB 190 1e-48 4X3F-A nrPDB 190 1e-48 4OW8-A nrPDB 190 1e-48 3QUP-A nrPDB 190 1e-48 4R7H-A nrPDB 190 1e-48 4M7I-A nrPDB 189 1e-48 1K9A-A nrPDB 189 1e-48 4WUA-A nrPDB 189 2e-48 5U6B-A nrPDB 189 2e-48 6J5U-C nrPDB 189 2e-48 4OTD-A nrPDB 189 2e-48 5FM2-A nrPDB 189 2e-48 4C59-A nrPDB 189 2e-48 5GRN-A nrPDB 188 3e-48 4HVI-A nrPDB 188 3e-48 5U6C-A nrPDB 188 3e-48 4LRM-A nrPDB 188 5e-48 1BYG-A nrPDB 187 5e-48 3LLT-A nrPDB 187 6e-48 1S9I-A nrPDB 187 6e-48 1FVR-A nrPDB 187 6e-48 3SXS-A nrPDB 187 9e-48 4Y93-A nrPDB 186 1e-47 4YHJ-A nrPDB 186 1e-47 3MDY-A nrPDB 186 1e-47 1AD5-A nrPDB 186 1e-47 6FER-A nrPDB 186 1e-47 4XI2-A nrPDB 186 2e-47 4CRS-A nrPDB 186 2e-47 6E4F-A nrPDB 185 2e-47 3PLS-A nrPDB 185 3e-47 5HVK-A nrPDB 185 3e-47 1U59-A nrPDB 185 3e-47 1PY5-A nrPDB 185 4e-47 2A1A-B nrPDB 184 4e-47 6CTH-A nrPDB 184 5e-47 5TUR-A nrPDB 183 1e-46 3BGP-A nrPDB 183 1e-46 3I81-A nrPDB 183 1e-46 2OZO-A nrPDB 183 1e-46 3Q4U-A nrPDB 183 1e-46 2RIO-A nrPDB 182 2e-46 4HZS-A nrPDB 182 2e-46 4RC3-A nrPDB 182 3e-46 3MY0-A nrPDB 181 5e-46 4PL5-B nrPDB 180 6e-46 1U54-B nrPDB 180 7e-46 6HV0-A nrPDB 180 8e-46 3UIU-A nrPDB 180 1e-45 4TPT-A nrPDB 180 1e-45 5B2L-A nrPDB 179 1e-45 4YFF-A nrPDB 179 2e-45 5VD3-A nrPDB 177 6e-45 5WNL-A nrPDB 177 1e-44 2WTK-B nrPDB 176 1e-44 3UIM-A nrPDB 176 1e-44 5LPZ-A nrPDB 176 1e-44 5LPV-A nrPDB 175 2e-44 4X7Q-B nrPDB 174 4e-44 2BUJ-A nrPDB 174 4e-44 2H34-A nrPDB 174 4e-44 3SOC-A nrPDB 174 4e-44 3ZZW-A nrPDB 174 6e-44 4NEU-A nrPDB 173 1e-43 4JLC-A nrPDB 173 1e-43 4Y83-A nrPDB 172 2e-43 5TE0-A nrPDB 172 2e-43 4EUU-A nrPDB 172 3e-43 5WNO-A nrPDB 171 4e-43 4EUT-A nrPDB 170 7e-43 2PMN-X nrPDB 170 1e-42 5XD6-A nrPDB 168 2e-42 6O8B-A nrPDB 168 3e-42 6NT9-A nrPDB 168 3e-42 3G2F-A nrPDB 168 4e-42 3QD2-B nrPDB 168 4e-42 4F9B-A nrPDB 167 1e-41 5IKW-A nrPDB 166 1e-41 4FL3-A nrPDB 165 3e-41 4IDT-A nrPDB 165 4e-41 4F0G-A nrPDB 165 4e-41 2QKW-B nrPDB 165 4e-41 5C26-A nrPDB 161 4e-40 5E8V-A nrPDB 160 7e-40 4G3E-A nrPDB 160 1e-39 2QLU-A nrPDB 160 1e-39 3LMG-A nrPDB 160 1e-39 4M66-A nrPDB 158 3e-39 6BFN-A nrPDB 157 8e-39 5AR8-A nrPDB 156 1e-38 6DC0-A nrPDB 153 1e-37 5CEK-A nrPDB 153 2e-37 2Y4I-B nrPDB 150 1e-36 4BTK-A nrPDB 143 8e-35 5J0A-A nrPDB 143 1e-34 4NFN-A nrPDB 142 2e-34 5L2Q-C nrPDB 139 1e-33 4LQP-A nrPDB 139 1e-33 3VHK-A nrPDB 139 2e-33 3HNG-A nrPDB 136 2e-32 2PZI-A nrPDB 135 4e-32 4Y12-A nrPDB 134 5e-32 4RT7-A nrPDB 133 1e-31 5X1R-A nrPDB 131 4e-31 5VC6-A nrPDB 131 5e-31 4JRN-A nrPDB 130 7e-31 5FQD-C nrPDB 129 2e-30 3SV0-A nrPDB 128 3e-30 4TN6-A nrPDB 127 1e-29 4L68-A nrPDB 124 8e-29 5OAT-A nrPDB 118 4e-27 4NT4-A nrPDB 115 4e-26 2CHL-A nrPDB 114 8e-26 1CSN-A nrPDB 113 1e-25 2CMW-A nrPDB 111 5e-25 2RSV-A nrPDB 83 2e-16 2LAV-A nrPDB 80 2e-15 Sequences not found previously or not previously below threshold: 3ZBF-A nrPDB 184 5e-47 3AOX-A nrPDB 173 1e-43 4BTF-A nrPDB 125 3e-29 5VDK-A nrPDB 123 1e-28 4MWI-A nrPDB 123 1e-28 4M69-B nrPDB 121 6e-28 5X18-A nrPDB 115 4e-26 5M07-A nrPDB 114 7e-26 4L00-A nrPDB 112 3e-25 2C47-A nrPDB 111 4e-25 5USZ-A nrPDB 111 5e-25 4XHH-A nrPDB 108 4e-24 5UV4-A nrPDB 107 8e-24 4XHL-A nrPDB 106 1e-23 6EQI-C nrPDB 103 1e-22 3REP-A nrPDB 100 2e-21 4I94-A nrPDB 96 2e-20 5C01-A nrPDB 95 3e-20 4WOV-A nrPDB 95 5e-20 6J6I-B nrPDB 93 1e-19 5UU1-A nrPDB 82 5e-16 5CLR-A nrPDB 80 2e-15 4IX6-A nrPDB 79 4e-15 6G4J-A nrPDB 72 4e-13 4CI6-B nrPDB 70 1e-12 6EAS-A nrPDB 70 2e-12 5DMZ-A nrPDB 67 1e-11 4O1O-A nrPDB 67 2e-11 4OAU-C nrPDB 63 2e-10 2JII-A nrPDB 63 2e-10 6BHC-A nrPDB 59 3e-09 5GZA-A nrPDB 59 3e-09 5GZ9-A nrPDB 58 5e-09 6EWX-A nrPDB 58 6e-09 3ENH-A nrPDB 58 6e-09 4CYJ-A nrPDB 58 8e-09 6M7Z-A nrPDB 57 2e-08 4AZW-A nrPDB 53 2e-07 5VE6-A nrPDB 53 3e-07 4AZV-A nrPDB 52 4e-07 6G38-A nrPDB 50 1e-06 6R5K-O nrPDB 48 4e-06 4BWP-A nrPDB 48 6e-06 4XR7-L nrPDB 48 7e-06 4CZY-B nrPDB 42 3e-04 3BYV-A nrPDB 42 4e-04 3Q60-A nrPDB 41 8e-04 4WWA-A nrPDB 41 0.001 1TQM-A nrPDB 40 0.002 2W1Z-A nrPDB 40 0.002 3DZO-A nrPDB 39 0.003 6FAI-l nrPDB 36 0.019 5YK0-A nrPDB 36 0.033 4ZO4-A nrPDB 34 0.12 6G18-v nrPDB 34 0.12 4FDJ-A nrPDB 33 0.19 6FDN-A nrPDB 33 0.20 4BVU-A nrPDB 33 0.32 6GL3-A nrPDB 32 0.41 >4QTB-A nrPDB Length = 380 Score = 558 bits (1438), Expect = e-159, Method: Composition-based stats. Identities = 379/379 (100%), Positives = 379/379 (100%) Query: 1 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY Sbjct: 2 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 61 Query: 61 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI Sbjct: 62 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 121 Query: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 180 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL Sbjct: 122 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 181 Query: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS Sbjct: 182 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 241 Query: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD Sbjct: 242 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 301 Query: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL 360 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL Sbjct: 302 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL 361 Query: 361 KELIFQETARFQPGVLEAP 379 KELIFQETARFQPGVLEAP Sbjct: 362 KELIFQETARFQPGVLEAP 380 >5NGU-A nrPDB Length = 381 Score = 483 bits (1243), Expect = e-137, Method: Composition-based stats. Identities = 304/349 (87%), Positives = 326/349 (93%) Query: 29 EMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLRE 88 EMV+GQ FDVGPRYT L YIGEGAYGMV SAYD++ K RVAIKKISPFEHQTYCQRTLRE Sbjct: 31 EMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLRE 90 Query: 89 IQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148 I+ILLRFRHEN+IGI DI+RA T+E M+DVYIVQDLMETDLYKLLK+Q LSNDHICYFLY Sbjct: 91 IKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 150 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 QILRGLKYIHSANVLHRDLKPSNLL+NTTCDLKICDFGLAR+ADP+HDHTGFLTEYVATR Sbjct: 151 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 210 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED Sbjct: 211 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 270 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 328 LNCIIN+KARNYL SLP K KV W +LFP +DSKALDLLD+MLTFNP+KRI VE+ALAHP Sbjct: 271 LNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 330 Query: 329 YLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLE 377 YLEQYYDP+DEP+AE PF F MELDDLPKE+LKELIF+ETARFQPG Sbjct: 331 YLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 379 >4EWQ-A nrPDB Length = 383 Score = 397 bits (1020), Expect = e-111, Method: Composition-based stats. Identities = 168/351 (47%), Positives = 234/351 (66%), Gaps = 9/351 (2%) Query: 29 EMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLR 87 + + ++V RY L +G GAYG V +A+D RVA+KK+S PF+ + +RT R Sbjct: 34 QELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR 93 Query: 88 EIQILLRFRHENVIGIRDILRA-STLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYF 146 E+++L +HENVIG+ D+ +LE DVY+V LM DL ++K Q+L++DH+ + Sbjct: 94 ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL 153 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 +YQILRGLKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVA Sbjct: 154 IYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVA 207 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 TRWYRAPEIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P Sbjct: 208 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGA 267 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 E L I + ARNY+QSL K+ +A +F ++ A+DLL++ML + +KRIT +ALA Sbjct: 268 ELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 327 Query: 327 HPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLE 377 H Y QY+DP DEPVA+ P+ + E DL + K L + E F P L+ Sbjct: 328 HAYFAQYHDPDDEPVAD-PYDQSFESRDLLIDEWKSLTYDEVISFVPPPLD 377 >3OHT-A nrPDB Length = 389 Score = 392 bits (1006), Expect = e-109, Method: Composition-based stats. Identities = 162/352 (46%), Positives = 232/352 (65%), Gaps = 9/352 (2%) Query: 29 EMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLR 87 + + ++V RY L +G GAYG V S+YD ++A+KK+S PF+ + +RT R Sbjct: 40 QELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYR 99 Query: 88 EIQILLRFRHENVIGIRDILRAST-LEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYF 146 E+++L +HENVIG+ D+ +T LE DVY+V LM DL ++K Q+L++DH+ + Sbjct: 100 ELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL 159 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 +YQILRGLKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVA Sbjct: 160 IYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVA 213 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 TRWYRAPEIMLN Y ++DIWSVGCI+AE+L+ R +FPG +++QL I+ + G+P Sbjct: 214 TRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPA 273 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 ++ + + +ARNY+ SLP K +A +F ++ A+DLL++ML + +KRIT EALA Sbjct: 274 SVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALA 333 Query: 327 HPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEA 378 HPY QY+DP DEP +E P+ + E L E K L ++E F+ + Sbjct: 334 HPYFSQYHDPDDEPESE-PYDQSFESRQLEIEEWKRLTYEEVCSFETPPFDG 384 >4IC8-A nrPDB Length = 442 Score = 385 bits (989), Expect = e-107, Method: Composition-based stats. Identities = 174/343 (50%), Positives = 237/343 (69%), Gaps = 4/343 (1%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILL 93 FDVG Y ++ IG GAYG+VSSA + +VAIKKI + F+ T +RTLRE++IL Sbjct: 50 TFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILK 109 Query: 94 RFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKS-QQLSNDHICYFLYQIL 151 F+H+N+I I+DILR + + VY+V DLME+DL++++ S Q L+ +H+ YFLYQ+L Sbjct: 110 HFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLL 169 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA-DPEHDHTGFLTEYVATRWY 210 RGLKY+HSA V+HRDLKPSNLL+N C+LKI DFG+AR +H F+TEYVATRWY Sbjct: 170 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 229 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 RAPE+ML+ YT++ID+WSVGCI EML+ R +FPGK+Y+ QL I+ +LG+PS + Sbjct: 230 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 289 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + + R Y+QSLP + V W ++P +D +AL LL RML F P+ RI+ AL HP+L Sbjct: 290 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL 349 Query: 331 EQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 373 +Y+DP DEP PF FA + + L +ER+KE I E F Sbjct: 350 AKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHA 392 >2F9G-A nrPDB Length = 353 Score = 385 bits (988), Expect = e-107, Method: Composition-based stats. Identities = 175/353 (49%), Positives = 232/353 (65%), Gaps = 12/353 (3%) Query: 30 MVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREI 89 M K +++ + +GEGAYG+V SA VAIKKI PF+ + RTLREI Sbjct: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 Query: 90 QILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQ 149 +IL F+HEN+I I +I R + E +VYI+Q+LM+TDL++++ +Q LS+DHI YF+YQ Sbjct: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIAD-------PEHDHTGFLT 202 LR +K +H +NV+HRDLKPSNLLIN+ CDLK+CDFGLARI D +T Sbjct: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 Query: 203 EYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILG 262 EYVATRWYRAPE+ML S Y++++D+WS GCILAE+ RPIFPG+ Y QL I GI+G Sbjct: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 Query: 263 SP-SQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 321 +P S DL CI + +AR Y++SLP K+FP+ + K +DLL RML F+P KRIT Sbjct: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 Query: 322 EEALAHPYLEQYYDPTDEPVAEEP----FTFAMELDDLPKERLKELIFQETAR 370 +EAL HPYL+ Y+DP DEP E F F + L + LK+LI+ E Sbjct: 301 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 >4ZSG-A nrPDB Length = 347 Score = 383 bits (983), Expect = e-107, Method: Composition-based stats. Identities = 174/343 (50%), Positives = 237/343 (69%), Gaps = 4/343 (1%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILL 93 FDVG Y ++ IG GAYG+VSSA + +VAIKKI + F+ T +RTLRE++IL Sbjct: 2 TFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILK 61 Query: 94 RFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKS-QQLSNDHICYFLYQIL 151 F+H+N+I I+DILR + + VY+V DLME+DL++++ S Q L+ +H+ YFLYQ+L Sbjct: 62 HFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLL 121 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA-DPEHDHTGFLTEYVATRWY 210 RGLKY+HSA V+HRDLKPSNLL+N C+LKI DFG+AR +H F+TEYVATRWY Sbjct: 122 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 181 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 RAPE+ML+ YT++ID+WSVGCI EML+ R +FPGK+Y+ QL I+ +LG+PS + Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 241 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + + R Y+QSLP + V W ++P +D +AL LL RML F P+ RI+ AL HP+L Sbjct: 242 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL 301 Query: 331 EQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 373 +Y+DP DEP PF FA + + L +ER+KE I E F Sbjct: 302 AKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHA 344 >5Z33-A nrPDB Length = 425 Score = 381 bits (979), Expect = e-106, Method: Composition-based stats. Identities = 172/354 (48%), Positives = 240/354 (67%), Gaps = 6/354 (1%) Query: 30 MVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLRE 88 V Q F V RYT + +G+GAYG+V +A ++ VAIKK+ + F + +R LRE Sbjct: 21 KVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALRE 80 Query: 89 IQILLRFR-HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS-QQLSNDHICYF 146 I++L FR H N+ + D + + + Y+ ++LME DL +++S Q L++ H F Sbjct: 81 IKLLQHFRGHRNITCLYD-MDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSF 139 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYV 205 +YQIL GLKYIHSANVLHRDLKP NLL+N C+LKICDFGLAR + ++ G++TEYV Sbjct: 140 IYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYV 199 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 ATRWYRAPEIML+ + YTK+ID+WSVGCILAE+L RP F G+ Y+DQLN IL ILG+P+ Sbjct: 200 ATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPN 259 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 +E L+ I + +A+ Y+++LP K + LFP ++ ALDLLDRML F+P+ RI+VE+AL Sbjct: 260 EETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQAL 319 Query: 326 AHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP 379 HPYL ++D +DEP F F E+ + E ++++I E RF+ V AP Sbjct: 320 EHPYLHIWHDASDEPDCPTTFNFDFEVVEDVGE-MRKMILDEVYRFRQLVRTAP 372 >3GC9-A nrPDB Length = 370 Score = 380 bits (976), Expect = e-106, Method: Composition-based stats. Identities = 164/356 (46%), Positives = 233/356 (65%), Gaps = 9/356 (2%) Query: 18 EGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PF 76 E GP + + ++V R L+ +G GAYG V SAYD + +VA+KK+S PF Sbjct: 6 EMSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPF 65 Query: 77 EHQTYCQRTLREIQILLRFRHENVIGIRDILRAST-LEAMRDVYIVQDLMETDLYKLLKS 135 + + +RT RE+++L +HENVIG+ D+ +T +E +VY+V LM DL ++KS Sbjct: 66 QSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKS 125 Query: 136 QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH 195 Q LS++H+ + +YQ+LRGLKYIHSA ++HRDLKPSN+ +N +L+I DFGLAR AD E Sbjct: 126 QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEE- 184 Query: 196 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLN 255 +T YVATRWYRAPEIMLN Y +++DIWSVGCI+AE+L + +FPG Y+DQL Sbjct: 185 -----MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLK 239 Query: 256 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 315 I+ ++G+PS E L I + AR Y+QSLP + + +F ++ A+DLL RML + Sbjct: 240 RIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDS 299 Query: 316 NKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARF 371 ++R++ EALAH Y QY+DP DEP AE P+ ++E + E KEL +QE F Sbjct: 300 DQRVSAAEALAHAYFSQYHDPEDEPEAE-PYDESVEAKERTLEEWKELTYQEVLSF 354 >6DTL-A nrPDB Length = 364 Score = 374 bits (960), Expect = e-104, Method: Composition-based stats. Identities = 170/345 (49%), Positives = 236/345 (68%), Gaps = 8/345 (2%) Query: 33 GQPFDVGPRYTQ-LQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQ 90 G F+V +Y + IG+GAYG+V SA + VAIKKI + F+++ +RTLREI+ Sbjct: 22 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK 81 Query: 91 ILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQ 149 +L HEN++ IRDI+ A DVYI +LM+TDL+++++S Q LS +H YFLYQ Sbjct: 82 LLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQ 141 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW 209 ILRGLKYIHSANVLHRDLKPSNLL+N CDLKICDFGLAR+ + F+TEYV TRW Sbjct: 142 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTS----ESDFMTEYVVTRW 197 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 269 YRAPE++LNS YT +ID+WSVGCI E++ +P+FPG+ ++ QL ++ ++G+PS+ + Sbjct: 198 YRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSE-EE 256 Query: 270 NCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY 329 +N A+ Y++ LP + + FP A+DL+++MLTF+P +RITV +ALAHPY Sbjct: 257 LEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPY 316 Query: 330 LEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPG 374 L +D +DEP PF F E L +E++KELI++E F P Sbjct: 317 LNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPE 361 >1CM8-A nrPDB Length = 367 Score = 374 bits (960), Expect = e-104, Method: Composition-based stats. Identities = 146/348 (41%), Positives = 219/348 (62%), Gaps = 9/348 (2%) Query: 29 EMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLR 87 + V ++V Y LQ +G GAYG V SA D +VAIKK+ PF+ + + +R R Sbjct: 14 QEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR 73 Query: 88 EIQILLRFRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYF 146 E+++L RHENVIG+ D+ TL+ D Y+V M TDL KL+K ++L D I + Sbjct: 74 ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFL 133 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 +YQ+L+GL+YIH+A ++HRDLKP NL +N C+LKI DFGLAR AD E +T YV Sbjct: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE------MTGYVV 187 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 TRWYRAPE++LN YT+++DIWSVGCI+AEM++ + +F G +LDQL I+ + G+P Sbjct: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 E + + + +A+NY++ LP K +A + + A++LL++ML + +R+T EALA Sbjct: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 Query: 327 HPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPG 374 HPY E +D DEP ++ + + + D + K + ++E F+P Sbjct: 308 HPYFESLHDTEDEPQVQK-YDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354 >4MYG-A nrPDB Length = 372 Score = 373 bits (957), Expect = e-104, Method: Composition-based stats. Identities = 151/347 (43%), Positives = 223/347 (64%), Gaps = 9/347 (2%) Query: 29 EMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLR 87 + V +++ Y ++G GAYG V SA D +VAIKK+S PF+ + + +R R Sbjct: 32 QDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR 91 Query: 88 EIQILLRFRHENVIGIRDILRA-STLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYF 146 E+ +L +HENVIG+ D+ S+L D Y+V M+TDL K++ + S + I Y Sbjct: 92 ELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-GMEFSEEKIQYL 150 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 +YQ+L+GLKYIHSA V+HRDLKP NL +N C+LKI DFGLAR AD E +T YV Sbjct: 151 VYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVV 204 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 TRWYRAPE++L+ Y +++DIWSVGCI+AEML+ + +F GK YLDQL IL + G P Sbjct: 205 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 264 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 E + + + A++Y+QSLP + + +LFP++ +A DLL++ML + +KR+T +AL Sbjct: 265 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 324 Query: 327 HPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 373 HP+ E + DP +E A++PF ++E + L + K+ I++E F P Sbjct: 325 HPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 371 >4QNY-A nrPDB Length = 354 Score = 349 bits (895), Expect = 1e-96, Method: Composition-based stats. Identities = 148/358 (41%), Positives = 226/358 (63%), Gaps = 10/358 (2%) Query: 23 GVPGEVEMVKGQPFD--VGPRYTQLQYIGEGAYGMVSSAYD-HVRKTRVAIKKISP--FE 77 G+P + + Q + RY + IG G+YG+V A D VA+K+++ FE Sbjct: 1 GMPATKSLAELQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFE 60 Query: 78 HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS-Q 136 +R LREI++L F +N+IG+R+IL E YIV D+METDL ++L+S Q Sbjct: 61 EVILAKRILREIKLLAHFNDDNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRSGQ 120 Query: 137 QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 +L+ HI +F+YQ LR L IHSA V+HRD+ P+N+L+NT CDLKICDFGLA+ E+D Sbjct: 121 ELTEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAK---EEND 177 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 ++T+YV RWYRAPE+++ K Y+ ID+W +GCIL E+L +RP+F GK ++QL+ Sbjct: 178 QGEYMTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDK 237 Query: 257 ILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPN 316 I+ ++G+PS+ED+N + + A+ YL+ + + W + +P + +ALDLL ML FNP Sbjct: 238 IVDVIGTPSEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPK 297 Query: 317 KRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPG 374 +RITV +A+ HP+LEQ +D D+ ++ F F E + +K I++E+ +F Sbjct: 298 RRITVLQAMRHPFLEQLHDDADDNLSYALFRFD-ENEQKTIVDVKRAIYEESVKFHNE 354 >1JNK-A nrPDB Length = 423 Score = 348 bits (893), Expect = 3e-96, Method: Composition-based stats. Identities = 146/356 (41%), Positives = 223/356 (62%), Gaps = 24/356 (6%) Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89 V F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ Sbjct: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 Query: 90 QILLRFRHENVIGIRDILRA-STLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148 ++ H+N+I + ++ TLE +DVY+V +LM+ +L ++++ +L ++ + Y LY Sbjct: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLY 171 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A + +T YV TR Sbjct: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA----GTSFMMTPYVVTR 227 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 +YRAPE++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E Sbjct: 228 YYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNPN 316 + + RNY+++ P + + KLFP S S+A DLL +ML +P Sbjct: 287 MK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 Query: 317 KRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQETAR 370 KRI+V++AL HPY+ +YDP E A P + +LD+ E KELI++E Sbjct: 346 KRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 >5AWM-A nrPDB Length = 394 Score = 346 bits (889), Expect = 6e-96, Method: Composition-based stats. Identities = 142/360 (39%), Positives = 221/360 (61%), Gaps = 25/360 (6%) Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89 V F + RY L+ IG GA G+V +AYD + + VAIKK+S PF++ T+ +R RE Sbjct: 35 VGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREF 94 Query: 90 QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148 +++ H+N+IG+ + LE +DVY+V +LM+ +L ++++ L +D + Y LY Sbjct: 95 KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ-MDLDHDRMSYLLY 153 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 Q+L G+K++HSA ++HRDLKPSN+++ C LKI DFGLAR A T +T YV TR Sbjct: 154 QMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA----GTTFMMTPYVVTR 209 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 +YRAPE++L GYT+++DIWSVGCI+ EM+ +FPG ++DQ N I+ LG+PS Sbjct: 210 YYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSF 268 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFP-------------KSDSKALDLLDRMLTFNP 315 + + RNY+++ P T ++ +LFP + S A +LL +ML +P Sbjct: 269 MQR-LQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 327 Query: 316 NKRITVEEALAHPYLEQYYD--PTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 373 +RI+V+EAL H Y+ +YD D P A EP+ +++ + E+ KELI++E ++ Sbjct: 328 EQRISVDEALKHEYINVWYDAEEVDAP-APEPYDHSVDEREHTVEQWKELIYEEVMDYEA 386 >3E7O-A nrPDB Length = 360 Score = 345 bits (886), Expect = 1e-95, Method: Composition-based stats. Identities = 145/368 (39%), Positives = 225/368 (61%), Gaps = 26/368 (7%) Query: 21 GPGVPGEVEMVK--GQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFE 77 G + + V+ F V RY QL+ IG GA G+V +A+D V VA+KK+S PF+ Sbjct: 1 GSHMDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQ 60 Query: 78 HQTYCQRTLREIQILLRFRHENVIGIRDILRA-STLEAMRDVYIVQDLMETDLYKLLKSQ 136 +QT+ +R RE+ +L H+N+I + ++ TLE +DVY+V +LM+ +L +++ Sbjct: 61 NQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-M 119 Query: 137 QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 +L ++ + Y LYQ+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A Sbjct: 120 ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNF- 178 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 +T YV TR+YRAPE++L GY +++DIWSVGCI+ E++ IF G ++DQ N Sbjct: 179 ---MMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNK 234 Query: 257 ILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPK------------SDSKAL 304 ++ LG+PS E + + RNY+++ P+ +A+ +LFP S+A Sbjct: 235 VIEQLGTPSAEFM-AALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQAR 293 Query: 305 DLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKE 362 DLL +ML +P+KRI+V+EAL HPY+ +YDP E A P + +L++ E KE Sbjct: 294 DLLSKMLVIDPDKRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKE 352 Query: 363 LIFQETAR 370 LI++E Sbjct: 353 LIYKEVMD 360 >3OZ6-A nrPDB Length = 388 Score = 343 bits (880), Expect = 8e-95, Method: Composition-based stats. Identities = 143/378 (37%), Positives = 220/378 (58%), Gaps = 40/378 (10%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRF 95 V +Y ++ +G+GAYG+V + D VA+KKI F++ T QRT REI IL Sbjct: 6 HVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTEL 65 Query: 96 R-HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGL 154 HEN++ + ++LRA + RDVY+V D METDL+ ++++ L H Y +YQ+++ + Sbjct: 66 SGHENIVNLLNVLRA---DNDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKVI 122 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA------------------DPEHD 196 KY+HS +LHRD+KPSN+L+N C +K+ DFGL+R + D Sbjct: 123 KYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDD 182 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 LT+YVATRWYRAPEI+L S YTK ID+WS+GCIL E+L +PIFPG ++QL Sbjct: 183 DQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLER 242 Query: 257 ILGILGSPSQEDLNCIINMKARNYLQSLPSKTKV----------AWAKLFPKSDS----- 301 I+G++ PS ED+ I + A+ ++SL K ++ W L K + Sbjct: 243 IIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCN 302 Query: 302 -KALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAM-ELDDLPKER 359 +ALDLLD++L FNPNKRI+ +AL HP++ +++P +EP + T + + + Sbjct: 303 EEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNVKHSIDD 362 Query: 360 LKELIFQETARFQPGVLE 377 + L++ E +R + ++ Sbjct: 363 YRNLVYSEISRRKRELIS 380 >2XS0-A nrPDB Length = 386 Score = 341 bits (876), Expect = 2e-94, Method: Composition-based stats. Identities = 140/358 (39%), Positives = 220/358 (61%), Gaps = 24/358 (6%) Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89 + F V RY L+ IG GA G+V +AYD + + VAIKK+S PF++QT+ +R RE+ Sbjct: 17 IGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYREL 76 Query: 90 QILLRFRHENVIGIRDILRA-STLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148 ++ H+N+IG+ ++ +LE +DVYIV +LM+ +L ++++ +L ++ + Y LY Sbjct: 77 VLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLY 135 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A + + +V TR Sbjct: 136 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA----GTSFMMVPFVVTR 191 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 +YRAPE++L GY +++DIWSVGCI+ EM+ +FPG ++DQ N ++ LG+P E Sbjct: 192 YYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEF 250 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNPN 316 + + R Y+++ P ++ KLFP S+A DLL +ML + + Sbjct: 251 MK-KLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 309 Query: 317 KRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQETARFQ 372 KRI+V+EAL HPY+ +YDP+ E A P +LD+ E KELI++E + Sbjct: 310 KRISVDEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 366 >3RP9-A nrPDB Length = 458 Score = 335 bits (859), Expect = 2e-92, Method: Composition-based stats. Identities = 156/444 (35%), Positives = 221/444 (49%), Gaps = 74/444 (16%) Query: 3 AAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQP----------FDVGPRYTQLQYIGEGA 52 AAAAQ G G + +P + + RY IG G+ Sbjct: 6 AAAAQQHNSGTQHTVSGSQQEGQQRKQHHSSKPTASMPRPHSDWQIPDRYEIRHLIGTGS 65 Query: 53 YGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAST 111 YG V AYD + K VAIKKI FE C+R LREI IL R H++V+ + DI+ Sbjct: 66 YGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDIVIPKD 125 Query: 112 LEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPS 170 +E ++Y+V ++ ++D KL ++ L+ HI LY +L G+KY+HSA +LHRDLKP+ Sbjct: 126 VEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPA 185 Query: 171 NLLINTTCDLKICDFGLARIADPEHDHTGFL------------------------TEYVA 206 N L+N C +K+CDFGLAR D + L T +V Sbjct: 186 NCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVV 245 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-----------NRPIFPGKH------ 249 TRWYRAPE++L + YT++ID+WS+GCI AE+L+ P+FPG Sbjct: 246 TRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPGSSCFPLSP 305 Query: 250 --------------YLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKL 295 DQLN I ILG+PS+ED+ + A+ Y++ P + A+ Sbjct: 306 DQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIFPKREGTDLAER 365 Query: 296 FPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEE----PFTFAME 351 FP S + A+ LL RML FNPNKRIT+ E LAHP+ ++ E A E PF M Sbjct: 366 FPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRIAEVETNATEKVRLPFNDWMN 425 Query: 352 LDDLPKERLKELIFQETARFQPGV 375 +D+ +L+ +E R+ P + Sbjct: 426 MDE---PQLRYAFVKEIQRYHPEI 446 >4O2Z-A nrPDB Length = 377 Score = 333 bits (854), Expect = 8e-92, Method: Composition-based stats. Identities = 144/368 (39%), Positives = 211/368 (57%), Gaps = 15/368 (4%) Query: 14 PRRTEGVGPGVPGEVEM--VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIK 71 E P + G+ ++ V G PF+V +YT L+ +G GAYG+ S D +V+IK Sbjct: 17 QGNQELSVPKIVGDFKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIK 76 Query: 72 KISP-FEHQTYCQRTLREIQILLRFRHENVIGIRDIL--RASTLEAMRDVYIVQDLMETD 128 K F +R LREI ++ F HEN++ + +IL + DVY+V LM+ D Sbjct: 77 KCRDVFRDVEDGKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVD 136 Query: 129 LYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGL 187 + +L+S+Q L H+ YF+YQILRGLKY+HSANV HRDLKP+NL+ N +C+LKI DFGL Sbjct: 137 MNVVLRSRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGL 196 Query: 188 ARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 247 +R D + LT+YV TRWYR PE++L + Y+ ++DIWSVGCI AEM + +P+FPG Sbjct: 197 SRSVDVPYSE---LTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPG 253 Query: 248 KHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKS--DSKALD 305 ++ +DQL I +G P + ++ N L + KL P +++ +D Sbjct: 254 RNTMDQLRMIAQHIGKPPASIVEHREALEKLNELPD----GSLNIPKLVPGLAGNTEGID 309 Query: 306 LLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIF 365 L +M T +P+KR T + LAHPYL +D DEP PF +A E + L+ + Sbjct: 310 FLSKMWTLDPSKRPTAADMLAHPYLAHLHDEEDEPTCPCPFLWAHESTPMGVSELRRAFW 369 Query: 366 QETARFQP 373 + + P Sbjct: 370 ADIVDYNP 377 >3FI2-A nrPDB Length = 353 Score = 330 bits (847), Expect = 5e-91, Method: Composition-based stats. Identities = 139/354 (39%), Positives = 215/354 (60%), Gaps = 31/354 (8%) Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89 V F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ Sbjct: 15 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 74 Query: 90 QILLRFRHENVIGIRDILRA-STLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148 ++ H+N+I + ++ TLE +DVY+V +LM+ +L ++++ +L ++ + Y LY Sbjct: 75 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLY 133 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A + +T YV TR Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA----GTSFMMTPYVVTR 189 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 +YRAPE++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E Sbjct: 190 YYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 248 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNPN 316 + + RNY+++ P + + KLFP S S+A DLL +ML +P Sbjct: 249 MK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 307 Query: 317 KRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETAR 370 KRI+V++AL HPY+ +Y + + E KELI++E Sbjct: 308 KRISVDDALQHPYINVWYX----------XXXXXDEREHTIEEWKELIYKEVMN 351 >2BPM-A nrPDB Length = 309 Score = 330 bits (846), Expect = 7e-91, Method: Composition-based stats. Identities = 115/315 (36%), Positives = 170/315 (53%), Gaps = 14/315 (4%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILL 93 P + +++ IGEG YG+V A + + VA+KKI E + +REI +L Sbjct: 2 PLVDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK 61 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLS---NDHICYFLYQI 150 H N++ + D++ +Y+V + + DL K + + L+ I +L+Q+ Sbjct: 62 ELNHPNIVKLLDVIHTE-----NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQL 116 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY 210 L+GL + HS VLHRDLKP NLLINT +K+ DFGLAR T V T WY Sbjct: 117 LQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP---VRTYTHEVVTLWY 173 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 RAPEI+L K Y+ ++DIWS+GCI AEM++ R +FPG +DQL I LG+P + Sbjct: 174 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 233 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + +M +Y S P + ++K+ P D LL +ML ++PNKRI+ + ALAHP+ Sbjct: 234 GVTSMP--DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 291 Query: 331 EQYYDPTDEPVAEEP 345 + P E P Sbjct: 292 QDVTKPVPHLRLERP 306 >3N9X-A nrPDB Length = 432 Score = 324 bits (831), Expect = 3e-89, Method: Composition-based stats. Identities = 138/395 (34%), Positives = 205/395 (51%), Gaps = 54/395 (13%) Query: 34 QPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP-FEHQTYCQRTLREIQIL 92 + V Y IG G+YG V AYD + VAIKK++ FE C+R LREI IL Sbjct: 20 KNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITIL 79 Query: 93 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQL-SNDHICYFLYQIL 151 R + + +I + D++ L ++YIV ++ ++DL KL K+ + +HI LY +L Sbjct: 80 NRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIFLTEEHIKTILYNLL 139 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDH-------------- 197 G +IH + ++HRDLKP+N L+N C +K+CDFGLAR + E D Sbjct: 140 LGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGP 199 Query: 198 -----TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-----------N 241 LT +V TRWYRAPE++L + YTKSIDIWS GCI AE+L+ Sbjct: 200 HNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNR 259 Query: 242 RPIFPG-----------------KHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSL 284 P+FPG K DQLN I I+G+P+++DL I + Y++ Sbjct: 260 FPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLF 319 Query: 285 PSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEE 344 P + + + +P ++LL+ ML FNPNKRIT+++AL HPYL+ E + + Sbjct: 320 PHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRKKKLENFSTK 379 Query: 345 PFTFAMELDD---LPKERLKELIFQETARFQPGVL 376 + DD L + +L+ + +E F P ++ Sbjct: 380 --KIILPFDDWMVLSETQLRYIFLKEVQSFHPELV 412 >3NIE-A nrPDB Length = 429 Score = 319 bits (817), Expect = 1e-87, Method: Composition-based stats. Identities = 137/398 (34%), Positives = 203/398 (51%), Gaps = 57/398 (14%) Query: 34 QPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP-FEHQTYCQRTLREIQIL 92 + V Y IG G+YG V AYD VAIKK++ FE C+R LREI IL Sbjct: 22 KNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITIL 81 Query: 93 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQL-SNDHICYFLYQIL 151 R + + +I + D++ L ++YIV ++ ++DL KL K+ + H+ LY +L Sbjct: 82 NRLKSDYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIFLTEQHVKTILYNLL 141 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDH-------------- 197 G K+IH + ++HRDLKP+N L+N C +KICDFGLAR + + D Sbjct: 142 LGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEE 201 Query: 198 --------TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS--------- 240 LT +V TRWYRAPE++L + YT SIDIWS GCI AE+L+ Sbjct: 202 PGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNP 261 Query: 241 --NRPIFPG-----------------KHYLDQLNHILGILGSPSQEDLNCIINMKARNYL 281 P+FPG K DQLN I ++G+P +EDL CI + Y+ Sbjct: 262 TNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYI 321 Query: 282 QSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPV 341 + P++ + +K + + +DLL+ ML FN KRIT+++AL+HPYL+ E Sbjct: 322 KLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKENLENF 381 Query: 342 AEEPFTFAMELDD---LPKERLKELIFQETARFQPGVL 376 + E + DD L + +L+ + +E F ++ Sbjct: 382 STE--KIILPFDDWMVLSETQLRYIFLKEIQSFHADLI 417 >3NIZ-A nrPDB Length = 311 Score = 315 bits (808), Expect = 2e-86, Method: Composition-based stats. Identities = 111/301 (36%), Positives = 168/301 (55%), Gaps = 13/301 (4%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFR 96 + +Y +L+ +GEG YG+V A D VA+K+I E + +REI +L Sbjct: 19 LMEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLKELH 77 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ--LSNDHICYFLYQILRGL 154 H N++ + D++ + R + +V + ME DL K+L + L + I +LYQ+LRG+ Sbjct: 78 HPNIVSLIDVIHSE-----RCLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGV 132 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 + H +LHRDLKP NLLIN+ LK+ DFGLAR T V T WYRAP+ Sbjct: 133 AHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAF---GIPVRSYTHEVVTLWYRAPD 189 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 +++ SK Y+ S+DIWS+GCI AEM++ +P+FPG DQL I ILG+P+ + + Sbjct: 190 VLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQE 249 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 334 + ++ K W+ + P + +DLL ML F+PNKRI+ +A+ HPY + Sbjct: 250 LPLWK-QRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLD 308 Query: 335 D 335 Sbjct: 309 P 309 >3PG1-A nrPDB Length = 362 Score = 311 bits (796), Expect = 5e-85, Method: Composition-based stats. Identities = 133/345 (38%), Positives = 198/345 (57%), Gaps = 21/345 (6%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI----------SPFEHQTYCQRTLREIQI 91 YT ++I G+YG V + D VAIK++ + C+R LREI++ Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQL--SNDHICYFLYQ 149 L F H N++G+RDI AM +Y+V +LM TDL +++ Q++ S HI YF+Y Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMYH 142 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW 209 IL GL +H A V+HRDL P N+L+ D+ ICDF LAR + + T ++T RW Sbjct: 143 ILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTH----RW 198 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 269 YRAPE+++ KG+TK +D+WS GC++AEM + + +F G + +QLN I+ ++G+P ED+ Sbjct: 199 YRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDV 258 Query: 270 NCIINMKARNYLQ-SLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 328 + AR+YL+ SL + AW + P +D ALDL+ +ML FNP +RI+ E+AL HP Sbjct: 259 VMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHP 318 Query: 329 YLEQYYDPTDEPVA-EEPFTFAMELDDLPKERLKELIFQETARFQ 372 Y E +DP D E F F + D + ++ E RF Sbjct: 319 YFESLFDPLDLTEGLSERFHFDESVTD--VYDMHKIFTAEVERFN 361 >2I6L-A nrPDB Length = 320 Score = 308 bits (788), Expect = 4e-84, Method: Composition-based stats. Identities = 139/316 (43%), Positives = 198/316 (62%), Gaps = 12/316 (3%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95 FD+G RY L+ +G G G+V SA D+ RVAIKKI + LREI+I+ R Sbjct: 7 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI-VLTDPQSVKHALREIKIIRRL 65 Query: 96 RHENVIGIRDILRASTLEAMRDV---------YIVQDLMETDLYKLLKSQQLSNDHICYF 146 H+N++ + +IL S + DV YIVQ+ METDL +L+ L +H F Sbjct: 66 DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLF 125 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLIN-TTCDLKICDFGLARIADPEHDHTGFLTEYV 205 +YQ+LRGLKYIHSANVLHRDLKP+NL IN LKI DFGLARI DP + H G L+E + Sbjct: 126 MYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGL 185 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 T+WYR+P ++L+ YTK+ID+W+ GCI AEML+ + +F G H L+Q+ IL + Sbjct: 186 VTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVH 245 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 +ED ++++ Y+++ ++ +L P +A+D L+++LTF+P R+T EEAL Sbjct: 246 EEDRQELLSV-IPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEAL 304 Query: 326 AHPYLEQYYDPTDEPV 341 +HPY+ Y P DEP+ Sbjct: 305 SHPYMSIYSFPMDEPI 320 >6GU6-A nrPDB Length = 302 Score = 307 bits (786), Expect = 6e-84, Method: Composition-based stats. Identities = 108/304 (35%), Positives = 162/304 (53%), Gaps = 15/304 (4%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILL 93 P YT+++ IGEG YG+V VA+KKI E + +REI +L Sbjct: 2 PLGSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLK 61 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS----QQLSNDHICYFLYQ 149 RH N++ ++D+L + +Y++ + + DL K L S Q + + + +LYQ Sbjct: 62 ELRHPNIVSLQDVLMQDSR-----LYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQ 116 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW 209 IL+G+ + HS VLHRDLKP NLLI+ +K+ DFGLAR T V T W Sbjct: 117 ILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVYTHEVVTLW 173 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 269 YR+PE++L S Y+ +DIWS+G I AE+ + +P+F G +DQL I LG+P+ E Sbjct: 174 YRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 233 Query: 270 NCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY 329 + ++ ++Y + P + A D LDLL +ML ++P KRI+ + AL HPY Sbjct: 234 PEVESL--QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 291 Query: 330 LEQY 333 Sbjct: 292 FNDL 295 >4AU8-A nrPDB Length = 296 Score = 304 bits (779), Expect = 4e-83, Method: Composition-based stats. Identities = 108/301 (35%), Positives = 162/301 (53%), Gaps = 14/301 (4%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHE 98 +Y +L+ IGEG YG V A + VA+K++ + + LREI +L +H+ Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 65 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS--QQLSNDHICYFLYQILRGLKY 156 N++ + D+L + + + +V + + DL K S L + + FL+Q+L+GL + Sbjct: 66 NIVRLHDVLHSD-----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 120 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 HS NVLHRDLKP NLLIN +LK+ DFGLAR + V T WYR P+++ Sbjct: 121 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVL 177 Query: 217 LNSKGYTKSIDIWSVGCILAEML-SNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 +K Y+ SID+WS GCI AE+ + RP+FPG DQL I +LG+P++E + + Sbjct: 178 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 237 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 P + + PK ++ DLL +L NP +RI+ EEAL HPY + Sbjct: 238 PDYKPYPMYP--ATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 295 Query: 336 P 336 P Sbjct: 296 P 296 >4KRC-A nrPDB Length = 317 Score = 304 bits (778), Expect = 5e-83, Method: Composition-based stats. Identities = 98/305 (32%), Positives = 160/305 (52%), Gaps = 18/305 (5%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 ++ QL+ +G G Y V + VA+K++ + +REI ++ +HEN Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ-------QLSNDHICYFLYQILR 152 ++ + D++ + +V + M+ DL K + S+ L + + YF +Q+L+ Sbjct: 65 IVRLYDVIHTE-----NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 GL + H +LHRDLKP NLLIN LK+ DFGLAR + V T WYRA Sbjct: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF---GIPVNTFSSEVVTLWYRA 176 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 P++++ S+ Y+ SIDIWS GCILAEM++ +P+FPG + +QL I I+G+P++ + Sbjct: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 Query: 273 INMKA--RNYLQSLPSKTKVAWAKLFPK-SDSKALDLLDRMLTFNPNKRITVEEALAHPY 329 + N Q P + + D +D L +L NP+ R++ ++AL HP+ Sbjct: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 Query: 330 LEQYY 334 +YY Sbjct: 297 FAEYY 301 >1V0B-A nrPDB Length = 288 Score = 301 bits (771), Expect = 3e-82, Method: Composition-based stats. Identities = 112/297 (37%), Positives = 161/297 (54%), Gaps = 14/297 (4%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRH 97 +Y L+ IGEG YG+V A ++ A+KKI E + T+REI IL +H Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILRGLK 155 N++ + D++ + + +V + ++ DL KLL L + FL Q+L G+ Sbjct: 60 SNIVKLYDVIHT-----KKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIA 114 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 Y H VLHRDLKP NLLIN +LKI DFGLAR T V T WYRAP++ Sbjct: 115 YCHDRRVLHRDLKPQNLLINREGELKIADFGLARAF---GIPVRKYTHEVVTLWYRAPDV 171 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 ++ SK Y+ +IDIWSVGCI AEM++ P+FPG DQL I ILG+P+ ++ + Sbjct: 172 LMGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVT-- 229 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 + Y + + W D +DLL +ML +PN+RIT ++AL H Y ++ Sbjct: 230 ELPKYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >5EFQ-A nrPDB Length = 347 Score = 299 bits (767), Expect = 9e-82, Method: Composition-based stats. Identities = 112/333 (33%), Positives = 170/333 (51%), Gaps = 13/333 (3%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHE 98 ++ + IGEG YG V A D VA+KK+ E + + +REI+IL + H+ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 99 NVIGIRDILRAST-----LEAMRDVYIVQDLMETDLYKLLKSQ--QLSNDHICYFLYQIL 151 ++I +++I+ + Y+V + M+ DL LL+S + +HI F+ Q++ Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 130 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 GL Y H N LHRD+K SN+L+N +K+ DFGLAR+ E T V T WYR Sbjct: 131 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRP--YTNKVITLWYR 188 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 PE++L + YT +ID+WS GCIL E+ + +PIF L QL I I GSP Sbjct: 189 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPD 248 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 +I + N ++ + + F + ALDL D ML +P+KR T E+AL +L Sbjct: 249 VIKLPYFNTMKPKKQYRRK-LREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLR 307 Query: 332 QYYDPTDEPVAEEPFTFA-MELDDLPKERLKEL 363 +P+ P + P EL + R K++ Sbjct: 308 D-VEPSKMPPPDLPLWQDCHELWSKKRRRQKQM 339 >5JN2-A nrPDB Length = 525 Score = 298 bits (762), Expect = 3e-81, Method: Composition-based stats. Identities = 96/379 (25%), Positives = 164/379 (43%), Gaps = 56/379 (14%) Query: 5 AAQGGGGGEPR-RTEGVG-PGVPGEV------EMVKGQPFDVGPRYTQLQYIGEGAYGMV 56 + GG GEPR R G G PG+ V+ RY + +G+G++G V Sbjct: 24 STLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEV 83 Query: 57 SSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEA 114 D + A+K IS + +T + LRE+Q+L + H N++ + + E Sbjct: 84 ILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFF-----ED 138 Query: 115 MRDVYIVQD-LMETDLYK-LLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNL 172 Y+V + +L+ ++ ++ S + Q+L G+ Y+H ++HRDLKP NL Sbjct: 139 KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL 198 Query: 173 LI---NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIW 229 L+ + +++I DFGL+ + + + + + T +Y APE++ + Y + D+W Sbjct: 199 LLESKSKDANIRIIDFGLSTHFEA----SKKMKDKIGTAYYIAPEVLHGT--YDEKCDVW 252 Query: 230 SVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTK 289 S G IL +LS P F G + D L + + Y LP K Sbjct: 253 STGVILYILLSGCPPFNGANEYDILKKV------------------EKGKYTFELPQWKK 294 Query: 290 VAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP---TDEPVAEEPF 346 V A DL+ +MLT+ P+ RI+ +AL H +++ Y D P + Sbjct: 295 V---------SESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAI 345 Query: 347 TFAMELDDLPKERLKELIF 365 + K L++ Sbjct: 346 LNIRQFQGTQKLAQAALLY 364 >4NST-A nrPDB Length = 351 Score = 294 bits (754), Expect = 3e-80, Method: Composition-based stats. Identities = 111/344 (32%), Positives = 171/344 (49%), Gaps = 14/344 (4%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHE 98 ++ + IGEG YG V A D VA+KK+ E + + +REI+IL + H Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 99 NVIGIRDILRAST-----LEAMRDVYIVQDLMETDLYKLLKSQ--QLSNDHICYFLYQIL 151 +V+ +++I+ + Y+V + M+ DL LL+S S DHI F+ Q++ Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLM 132 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 GL+Y H N LHRD+K SN+L+N + +K+ DFGLAR+ + E T V T WYR Sbjct: 133 EGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRP--YTNKVITLWYR 190 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 PE++L + YT +ID+WS GCIL E+ + +PIF L QL I + GSP Sbjct: 191 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPD 250 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 +I + N ++ + + F S ALDLLD MLT +P+KR T E+ L +L+ Sbjct: 251 VIKLPYFNTMKPKKQYRRR-LREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLK 309 Query: 332 QYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGV 375 +A + +L ++ + +P Sbjct: 310 DV---ELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPP 350 >1UA2-A nrPDB Length = 346 Score = 294 bits (752), Expect = 5e-80, Method: Composition-based stats. Identities = 115/330 (34%), Positives = 166/330 (50%), Gaps = 25/330 (7%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS----PFEHQTYCQRTLREIQILLR 94 RY +L ++GEG + V A D VAIKKI + LREI++L Sbjct: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQL--SNDHICYFLYQILR 152 H N+IG+ D + ++ +V D METDL ++K L + HI ++ L+ Sbjct: 69 LSHPNIIGLLDAFGHKS-----NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 GL+Y+H +LHRDLKP+NLL++ LK+ DFGLA+ + T V TRWYRA Sbjct: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN---RAYTHQVVTRWYRA 180 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++ ++ Y +D+W+VGCILAE+L P PG LDQL I LG+P++E + Sbjct: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 ++ +S P + +F + LDL+ + FNP RIT +AL Y Sbjct: 241 CSLPDYVTFKSFP---GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 Query: 333 YYDPTDEPVAEEPFTFAMELDDLPKERLKE 362 PT P + P + P E LKE Sbjct: 298 RPGPT--PGCQLPRP------NCPVETLKE 319 >1G3N-A nrPDB Length = 326 Score = 293 bits (751), Expect = 7e-80, Method: Composition-based stats. Identities = 109/302 (36%), Positives = 159/302 (52%), Gaps = 17/302 (5%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTR-VAIKKIS-PFEHQTYCQRTLREIQILLRFR- 96 +Y + IGEGAYG V A D R VA+K++ + T+RE+ +L Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 97 --HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS---QQLSNDHICYFLYQIL 151 H NV+ + D+ S + + +V + ++ DL L + + I ++Q+L Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 RGL ++HS V+HRDLKP N+L+ ++ +K+ DFGLARI LT V T WYR Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS----FQMALTSVVVTLWYR 186 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 APE++L S Y +D+WSVGCI AEM +P+F G +DQL IL ++G P +ED Sbjct: 187 APEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + + Q+ SK+ K D DLL + LTFNP KRI+ AL+HPY + Sbjct: 246 DVALPR----QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 Query: 332 QY 333 Sbjct: 302 DL 303 >3NCG-A nrPDB Length = 486 Score = 293 bits (750), Expect = 1e-79, Method: Composition-based stats. Identities = 92/337 (27%), Positives = 154/337 (45%), Gaps = 48/337 (14%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQ-TYCQRTLREIQILLRFRH 97 RY + +G+G++G V D + + A+K I+ + LRE+++L + H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYK-LLKSQQLSNDHICYFLYQILRGLK 155 N++ + +IL S+ YIV +L +L+ ++K ++ S + Q+ G+ Sbjct: 81 PNIMKLFEILEDSSS-----FYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGIT 135 Query: 156 YIHSANVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 Y+H N++HRDLKP N+L+ + CD+KI DFGL+ + + + T +Y A Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQ----QNTKMKDRIGTAYYIA 191 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++ + Y + D+WS G IL +LS P F GK+ D L + Sbjct: 192 PEVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV--------------- 234 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 + Y LP A DL+ +MLTF+P+ RIT + L HP++++ Sbjct: 235 ---ETGKYAFDLPQWR---------TISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQK 282 Query: 333 YYDPT----DEPVAEEPFTFAMELDDLPKERLKELIF 365 Y T D P E T + K L++ Sbjct: 283 YSSETPTISDLPSLESAMTNIRQFQAEKKLAQAALLY 319 >3MIA-A nrPDB Length = 351 Score = 290 bits (743), Expect = 6e-79, Method: Composition-based stats. Identities = 103/310 (33%), Positives = 155/310 (50%), Gaps = 8/310 (2%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKK-ISPFEHQTYCQRTLREIQILLRF 95 D +Y +L IG+G +G V A +VA+KK + E + + LREI+IL Sbjct: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 Query: 96 RHENVIGIRDILRA---STLEAMRDVYIVQDLMETDLYKLLKSQ--QLSNDHICYFLYQI 150 +HENV+ + +I R +Y+V D E DL LL + + + I + + Sbjct: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIAD-PEHDHTGFLTEYVATRW 209 L GL YIH +LHRD+K +N+LI LK+ DFGLAR ++ T V T W Sbjct: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 269 YR PE++L + Y ID+W GCI+AEM + PI G QL I + GS + E Sbjct: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Query: 270 NCIINMKARNYLQSLPSKTKVAWAKLFPKS-DSKALDLLDRMLTFNPNKRITVEEALAHP 328 + N + L+ + + + +L D ALDL+D++L +P +RI ++AL H Sbjct: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 Query: 329 YLEQYYDPTD 338 + P+D Sbjct: 314 FFWSDPMPSD 323 >4BBM-A nrPDB Length = 331 Score = 290 bits (742), Expect = 8e-79, Method: Composition-based stats. Identities = 89/299 (29%), Positives = 155/299 (51%), Gaps = 11/299 (3%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT-LREIQILLR 94 F +Y L +GEG+YGMV + VAIKK + ++ +REI++L + Sbjct: 21 FQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQ 80 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILR 152 RHEN++ + ++ + + Y+V + ++ + L+ L + +L+QI+ Sbjct: 81 LRHENLVNLLEVCKK-----KKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIIN 135 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 G+ + HS N++HRD+KP N+L++ + +K+CDFG AR + + VATRWYRA Sbjct: 136 GIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGE---VYDDEVATRWYRA 192 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE+++ Y K++D+W++GC++ EM P+FPG +DQL HI+ LG+ Sbjct: 193 PELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELF 252 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 ++ K + + +PK +DL + L +P+KR E L H + + Sbjct: 253 NKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >3DFA-A nrPDB Length = 286 Score = 289 bits (741), Expect = 1e-78, Method: Composition-based stats. Identities = 85/304 (27%), Positives = 144/304 (47%), Gaps = 44/304 (14%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQ-TYCQRTLREIQILLRFRH 97 RY + +G+G++G V D + + A+K I+ + LRE+++L + H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYK-LLKSQQLSNDHICYFLYQILRGLK 155 N++ + +IL S+ YIV +L +L+ ++K ++ S + Q+ G+ Sbjct: 81 PNIMKLFEILEDSSS-----FYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGIT 135 Query: 156 YIHSANVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 Y+H N++HRDLKP N+L+ + CD+KI DFGL+ + + + T +Y A Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQ----QNTKMKDRIGTAYYIA 191 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++ + Y + D+WS G IL +LS P F GK+ D L + Sbjct: 192 PEVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV--------------- 234 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 + Y LP A DL+ +MLTF+P+ RIT + L HP++++ Sbjct: 235 ---ETGKYAFDLPQWR---------TISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQK 282 Query: 333 YYDP 336 Y Sbjct: 283 YSSE 286 >4AGU-A nrPDB Length = 311 Score = 287 bits (734), Expect = 7e-78, Method: Composition-based stats. Identities = 90/303 (29%), Positives = 151/303 (49%), Gaps = 11/303 (3%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT-LREIQILLRFRH 97 +Y ++ IGEG+YG+V + VAIKK E ++ LREI++L + +H Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS--QQLSNDHICYFLYQILRGLK 155 N++ + ++ R R +++V + + + L + + + +Q L+ + Sbjct: 62 PNLVNLLEVFRR-----KRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVN 116 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 + H N +HRD+KP N+LI +K+CDFG AR+ D+ + VATRWYR+PE+ Sbjct: 117 FCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDY---YDDEVATRWYRSPEL 173 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 ++ Y +D+W++GC+ AE+LS P++PGK +DQL I LG Sbjct: 174 LVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTN 233 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 + + ++ + FP AL LL L +P +R+T E+ L HPY E + Sbjct: 234 QYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIRE 293 Query: 336 PTD 338 D Sbjct: 294 IED 296 >3MA6-A nrPDB Length = 298 Score = 286 bits (731), Expect = 1e-77, Method: Composition-based stats. Identities = 84/324 (25%), Positives = 147/324 (45%), Gaps = 50/324 (15%) Query: 20 VGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-- 77 GPG+ V+ RY + +G+G++G V D + A+K IS + Sbjct: 17 QGPGM-----FVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVK 71 Query: 78 HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQD-LMETDLYK-LLKS 135 +T + LRE+Q+L + H N++ + + E Y+V + +L+ ++ Sbjct: 72 QKTDKESLLREVQLLKQLDHPNIMKLYEFF-----EDKGYFYLVGEVYTGGELFDEIISR 126 Query: 136 QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLI---NTTCDLKICDFGLARIAD 192 ++ S + Q+L G+ Y+H ++HRDLKP NLL+ + +++I DFGL+ + Sbjct: 127 KRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFE 186 Query: 193 PEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLD 252 + + + + T +Y APE++ + Y + D+WS G IL +LS P F G + D Sbjct: 187 A----SKKMKDKIGTAYYIAPEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEYD 240 Query: 253 QLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLT 312 L + + Y LP KV A DL+ +MLT Sbjct: 241 ILKKV------------------EKGKYTFELPQWKKV---------SESAKDLIRKMLT 273 Query: 313 FNPNKRITVEEALAHPYLEQYYDP 336 + P+ RI+ +AL H +++ Y Sbjct: 274 YVPSMRISARDALDHEWIQTYTKE 297 >5G6V-A nrPDB Length = 324 Score = 283 bits (725), Expect = 7e-77, Method: Composition-based stats. Identities = 102/294 (34%), Positives = 153/294 (52%), Gaps = 11/294 (3%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 Y +L +GEG Y V + VA+K+I + +RE+ +L +H Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 60 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS--QQLSNDHICYFLYQILRGLKY 156 N++ + DI+ + + +V + ++ DL + L ++ ++ FL+Q+LRGL Y Sbjct: 61 NIVTLHDIIHTE-----KSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY 115 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 H VLHRDLKP NLLIN +LK+ DFGLAR T V T WYR P+I+ Sbjct: 116 CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIP---TKTYDNEVVTLWYRPPDIL 172 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 L S Y+ ID+W VGCI EM + RP+FPG +QL+ I ILG+P++E I++ + Sbjct: 173 LGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNE 232 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + P A P+ DS DLL ++L F RI+ E+A+ HP+ Sbjct: 233 EFKT-YNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >3HZT-A nrPDB Length = 467 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 88/320 (27%), Positives = 144/320 (45%), Gaps = 45/320 (14%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ--RTLREIQILLRF 95 + RY +++ +G GAYG V D + AIK I T L E+ +L + Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQD-LMETDLYK-LLKSQQLSNDHICYFLYQILRG 153 H N++ + + E R+ Y+V + +L+ ++ Q+ S + Q+L G Sbjct: 62 DHPNIMKLYEFF-----EDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSG 116 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWY 210 Y+H N++HRDLKP NLL+ + +KI DFGL+ + G + E + T +Y Sbjct: 117 TTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHF----EVGGKMKERLGTAYY 172 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 APE++ K Y + D+WS G IL +L P F G+ + L + Sbjct: 173 IAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRV------------- 217 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + + P T+V +A L+ MLT+ P+KRI+ EEAL HP++ Sbjct: 218 -----EKGKFSFDPPDWTQV---------SDEAKQLVKLMLTYEPSKRISAEEALNHPWI 263 Query: 331 EQYYDPTDEPVAEEPFTFAM 350 ++ V + T A+ Sbjct: 264 VKFCSQKHTDVGKHALTGAL 283 >4MVF-A nrPDB Length = 506 Score = 283 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 80/298 (26%), Positives = 132/298 (44%), Gaps = 44/298 (14%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 +Y + +G+G YG V D V AIK+ + R +EI+I+ + H N Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKK-DRLKNINRFFQEIEIMKKLDHPN 115 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICYFLYQILRGLKYI 157 ++ + + T E +Y++ +L +L+ ++++ + + + QI + Y+ Sbjct: 116 IVKLYE-----TYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYL 170 Query: 158 HSANVLHRDLKPSNLLI---NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 HS N++HRDLKP N L N LKI DFGL++ F T T +Y AP+ Sbjct: 171 HSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGE----FTTTKAGTPYYVAPQ 226 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 ++ Y K DIWS G I+ +L P F G + L + Sbjct: 227 VLDGK--YDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKV----------------- 267 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 + + S A +L+ ++LT+NPN+R T+EEAL HP++ Q Sbjct: 268 ----------KKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQ 315 >5AIR-A nrPDB Length = 430 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 110/330 (33%), Positives = 173/330 (52%), Gaps = 34/330 (10%) Query: 16 RTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP 75 T G GP P EV YT + IG G++G+V A VAIKK+ Sbjct: 52 ATPGQGPDRPQEVS------------YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-- 97 Query: 76 FEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDLMETDLYKLL 133 + + + RE+QI+ + H N++ +R +S E +VY+ V D + +Y++ Sbjct: 98 LQDKRFKN---RELQIMRKLDHCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVA 153 Query: 134 K-----SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL-KICDFGL 187 + Q L ++ ++YQ+ R L YIHS + HRD+KP NLL++ + K+CDFG Sbjct: 154 RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGS 213 Query: 188 ARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 247 A+ + Y+ +R+YRAPE++ + YT SID+WS GC+LAE+L +PIFPG Sbjct: 214 AKQLVRGEPNVS----YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPG 269 Query: 248 KHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLF-PKSDSKALDL 306 +DQL I+ +LG+P++E + M P W K+F P++ +A+ L Sbjct: 270 DSGVDQLVEIIKVLGTPTREQIRE---MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIAL 326 Query: 307 LDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 R+L + P R+T EA AH + ++ DP Sbjct: 327 CSRLLEYTPTARLTPLEACAHSFFDELRDP 356 >2W96-B nrPDB Length = 306 Score = 281 bits (720), Expect = 3e-76, Method: Composition-based stats. Identities = 104/301 (34%), Positives = 153/301 (50%), Gaps = 16/301 (5%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFR- 96 RY + IG GAYG V A D VA+K + P + T+RE+ +L R Sbjct: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEA 62 Query: 97 --HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS---QQLSNDHICYFLYQIL 151 H NV+ + D+ S + V +V + ++ DL L L + I + Q L Sbjct: 63 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 RGL ++H+ ++HRDLKP N+L+ + +K+ DFGLARI + L V T WYR Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS----YQMALDPVVVTLWYR 178 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 APE++L S Y +D+WSVGCI AEM +P+F G DQL I ++G P ++D Sbjct: 179 APEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 237 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 +++ + P + + P+ + LL MLTFNP+KRI+ AL H YL Sbjct: 238 DVSLPRG----AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 293 Query: 332 Q 332 + Sbjct: 294 K 294 >3DXN-A nrPDB Length = 287 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 84/304 (27%), Positives = 136/304 (44%), Gaps = 45/304 (14%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ--RTLREIQILLRF 95 + RY +++ +G GAYG V D + AIK I T L E+ +L + Sbjct: 19 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 78 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQD-LMETDLYK-LLKSQQLSNDHICYFLYQILRG 153 H N++ + + E R+ Y+V + +L+ ++ Q+ S + Q+L G Sbjct: 79 DHPNIMKLYEFF-----EDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSG 133 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWY 210 Y+H N++HRDLKP NLL+ + +KI DFGL+ + G + E + T +Y Sbjct: 134 TTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHF----EVGGKMKERLGTAYY 189 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 APE++ K Y + D+WS G IL +L P F G+ + L + S D Sbjct: 190 IAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWT 247 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + +A L+ MLT+ P+KRI+ EEAL HP++ Sbjct: 248 QV---------------------------SDEAKQLVKLMLTYEPSKRISAEEALNHPWI 280 Query: 331 EQYY 334 ++ Sbjct: 281 VKFC 284 >3LIJ-A nrPDB Length = 494 Score = 277 bits (708), Expect = 7e-75, Method: Composition-based stats. Identities = 78/297 (26%), Positives = 136/297 (45%), Gaps = 44/297 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENV 100 Y +++ +G GAYG V D V AIK I + + L E+ +L H N+ Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNI 98 Query: 101 IGIRDILRASTLEAMRDVYIVQD-LMETDLYK-LLKSQQLSNDHICYFLYQILRGLKYIH 158 + + D E R+ Y+V + +L+ ++ + + + Q+L G+ Y+H Sbjct: 99 MKLYDFF-----EDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLH 153 Query: 159 SANVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 N++HRDLKP NLL+ + +KI DFGL+ + ++ + E + T +Y APE+ Sbjct: 154 KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVF----ENQKKMKERLGTAYYIAPEV 209 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + K Y + D+WS+G IL +L+ P F G+ + L + Sbjct: 210 L--RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKV------------------ 249 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 + Y P A DL+ +ML F+ +RI+ ++AL HP++++ Sbjct: 250 EKGKYTFDSPEWK---------NVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKE 297 >3GC0-A nrPDB Length = 329 Score = 274 bits (702), Expect = 4e-74, Method: Composition-based stats. Identities = 113/321 (35%), Positives = 164/321 (51%), Gaps = 19/321 (5%) Query: 25 PGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQ 83 PG + + RY ++ +GEG YG V A D V VAIK+I E + Sbjct: 19 PGSMSVSAAPSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPG 78 Query: 84 RTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL-KSQQLSNDH 142 +RE+ +L +H N+I ++ ++ + ++++ + E DL K + K+ +S Sbjct: 79 TAIREVSLLKELQHRNIIELKSVIHHN-----HRLHLIFEYAENDLKKYMDKNPDVSMRV 133 Query: 143 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN-----TTCDLKICDFGLARIADPEHDH 197 I FLYQ++ G+ + HS LHRDLKP NLL++ T LKI DFGLAR Sbjct: 134 IKSFLYQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQ 193 Query: 198 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 257 T + T WYR PEI+L S+ Y+ S+DIWS+ CI AEML P+FPG +DQL I Sbjct: 194 ---FTHEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKI 250 Query: 258 LGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLF-PKSDSKALDLLDRMLTFNPN 316 +LG P + + ++ QS P ++ D + LDLL ML +P Sbjct: 251 FEVLGLPDDTTWPGVTALP--DWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPV 308 Query: 317 KRITVEEALAHPYLEQ-YYDP 336 KRI+ + AL HPY +DP Sbjct: 309 KRISAKNALEHPYFSHNDFDP 329 >3ZDU-A nrPDB Length = 325 Score = 272 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 89/293 (30%), Positives = 147/293 (50%), Gaps = 10/293 (3%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 Y L +GEG+YG V VAIK Q+ + +REI+ L +F HEN++ Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLV 64 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILRGLKYIHS 159 + ++ R + +++V + ++ + L+ L + + +L+QILR + Y+HS Sbjct: 65 NLIEVFRQ-----KKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHS 119 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 N++HRD+KP N+L++ + K+CDFG AR D + VATRWYRAPE++L Sbjct: 120 NNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGD---IYDDEVATRWYRAPELVLKD 176 Query: 220 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN 279 Y K +DIW++GC++ EM + P P LD L+ I+ +G+ S N Sbjct: 177 TSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFA 236 Query: 280 YLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 + + K +PK + D++ L +P RI+ + L H Y + Sbjct: 237 GVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTR 289 >4RGJ-A nrPDB Length = 520 Score = 272 bits (696), Expect = 1e-73, Method: Composition-based stats. Identities = 81/310 (26%), Positives = 140/310 (45%), Gaps = 46/310 (14%) Query: 30 MVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP--FEHQTYCQRTLR 87 ++ +Y ++ +G+G++G V + D AIK IS + +T + LR Sbjct: 50 FIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLR 109 Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQD-LMETDLYK-LLKSQQLSNDHICY 145 E+++L H N++ + + E Y+V D +L+ ++ ++ Sbjct: 110 EVELLKMLDHINIMKLYEFF-----EDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAAR 164 Query: 146 FLYQILRGLKYIHSANVLHRDLKPSNLLI----NTTCDLKICDFGLARIADPEHDHTGFL 201 + QIL G+ Y+H NV+HRDLKP N+L+ +KI DFGL+ +++ + Sbjct: 165 IIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHF----EYSKKM 220 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 261 + + T +Y AP+++ + Y + DIWS G IL +LS P F G + D L + Sbjct: 221 KDKIGTAYYIAPDVLHGT--YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV---- 274 Query: 262 GSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 321 +A Y LP F K KA DL+ +ML + RI+ Sbjct: 275 --------------EAGKYTFDLPQ---------FKKISDKAKDLIKKMLMYTSAVRISA 311 Query: 322 EEALAHPYLE 331 +AL H +++ Sbjct: 312 RDALEHEWIK 321 >4BGQ-A nrPDB Length = 304 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 95/307 (30%), Positives = 161/307 (52%), Gaps = 12/307 (3%) Query: 29 EMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP-FEHQTYCQRTLR 87 M +V ++ L +GEGAYG+V VAIKK E++ + TLR Sbjct: 1 SMKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLR 60 Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS--QQLSNDHICY 145 E+++L + EN++ +++ R +Y+V + +E ++ +LL+ + + + Sbjct: 61 ELKMLRTLKQENIVELKEAFRRRG-----KLYLVFEYVEKNMLELLEEMPNGVPPEKVKS 115 Query: 146 FLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYV 205 ++YQ+++ + + H +++HRD+KP NLLI+ LK+CDFG AR ++ E V Sbjct: 116 YIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNN--ANYDEEV 173 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 ATRWYR+PE++L + Y KS+D+WSVGCIL E+ +P+FPG+ +DQL I +LG Sbjct: 174 ATRWYRSPELLLGA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLP 232 Query: 266 QEDLNCII-NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 E + N + + + + +S LDL+ +L +P R E+ Sbjct: 233 SEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQC 292 Query: 325 LAHPYLE 331 L HP + Sbjct: 293 LNHPTFQ 299 >4E7W-A nrPDB Length = 394 Score = 271 bits (692), Expect = 5e-73, Method: Composition-based stats. Identities = 107/360 (29%), Positives = 183/360 (50%), Gaps = 36/360 (10%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 YT + IG G++G+V A VAIKK+ + + + RE+QI+ +H NV+ Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKV--LQDKRFKN---RELQIMRIVKHPNVV 95 Query: 102 GIRDILRASTLEAMRDVY-IVQDLMETDLYKLLK-----SQQLSNDHICYFLYQILRGLK 155 ++ ++ + +V + + +Y+ + Q + I ++YQ+LR L Sbjct: 96 DLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLA 155 Query: 156 YIHSANVLHRDLKPSNLLINT-TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 YIHS + HRD+KP NLL++ + LK+ DFG A+I + Y+ +R+YRAPE Sbjct: 156 YIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVS----YICSRYYRAPE 211 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 ++ + YT +IDIWS GC++AE++ +P+FPG+ +DQL I+ +LG+PS+E + Sbjct: 212 LIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIK---T 268 Query: 275 MKARNYLQSLPSKTKVAWAKLF-PKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 M P ++K+F P++ A+DL+ R+L + P+ R+T EAL HP+ ++ Sbjct: 269 MNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDEL 328 Query: 334 YD-PTDEP---VAEEPFTFAMELDDLPKERLKELIFQ-----------ETARFQPGVLEA 378 P F + E + + + L+ Q + FQP LE+ Sbjct: 329 RTGEARMPNGRELPPLFNWTKEELSVRPDLISRLVPQHAEAELLSRGIDVHNFQPIPLES 388 >3Q5I-A nrPDB Length = 504 Score = 271 bits (692), Expect = 5e-73, Method: Composition-based stats. Identities = 80/332 (24%), Positives = 145/332 (43%), Gaps = 60/332 (18%) Query: 19 GVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEH 78 + PG+ V+ + +G Y +++ +G GAYG V + + AIK I + Sbjct: 20 AINPGM-----YVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQF 74 Query: 79 ------------QTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME 126 + + + EI +L H N+I + D+ E + Y+V + E Sbjct: 75 DKGRYSDDNKNIEKFHEEIYNEISLLKSLDHPNIIKLFDVF-----EDKKYFYLVTEFYE 129 Query: 127 T-DLYK-LLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC---DLK 181 +L++ ++ + + QIL G+ Y+H N++HRD+KP N+L+ ++K Sbjct: 130 GGELFEQIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIK 189 Query: 182 ICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN 241 I DFGL+ ++ L + + T +Y APE++ K Y + D+WS G I+ +L Sbjct: 190 IVDFGLSSFFSKDYK----LRDRLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYILLCG 243 Query: 242 RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDS 301 P F G++ D + + + Y + Sbjct: 244 YPPFGGQNDQDIIKKV------------------EKGKYYFDF---------NDWKNISD 276 Query: 302 KALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 +A +L+ MLT++ NKR T EEAL ++++Y Sbjct: 277 EAKELIKLMLTYDYNKRCTAEEALNSRWIKKY 308 >2BDW-A nrPDB Length = 362 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 85/325 (26%), Positives = 142/325 (43%), Gaps = 52/325 (16%) Query: 21 GPGV---PGEVEMVKGQPF------DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIK 71 GP + G +M +G F Y + +G+GA+ +V A K Sbjct: 1 GPHMASMTGGQQMGRGSEFMMNASTKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAK 60 Query: 72 KISPFE-HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDL 129 I+ + Q+ RE +I + +H N++ + D ++ + Y+V DL+ +L Sbjct: 61 IINTKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEESFH-----YLVFDLVTGGEL 115 Query: 130 YKLLKSQQL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD---LKICDF 185 ++ + +++ S + + QIL + Y HS ++HR+LKP NLL+ + +K+ DF Sbjct: 116 FEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADF 175 Query: 186 GLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 GLA E + + + T Y +PE++ Y+K +DIW+ G IL +L P F Sbjct: 176 GLA----IEVNDSEAWHGFAGTPGYLSPEVL-KKDPYSKPVDIWACGVILYILLVGYPPF 230 Query: 246 PGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALD 305 + I KA Y P W + P +A Sbjct: 231 WDEDQHRLYAQI------------------KAGAYDYPSPE-----WDTVTP----EAKS 263 Query: 306 LLDRMLTFNPNKRITVEEALAHPYL 330 L+D MLT NP KRIT ++AL P++ Sbjct: 264 LIDSMLTVNPKKRITADQALKVPWI 288 >5FG8-A nrPDB Length = 285 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 84/299 (28%), Positives = 138/299 (46%), Gaps = 42/299 (14%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHE 98 Y + +G+GA+ +V A K I+ + Q+ RE +I + H Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHP 73 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQL-SNDHICYFLYQILRGLKY 156 N++ + D ++ Y+V DL+ +L++ + +++ S + + QIL + + Sbjct: 74 NIVRLHDSIQEENYH-----YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNH 128 Query: 157 IHSANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 H V+HRDLKP NLL+ + +K+ DFGLA + + DH + + T Y +P Sbjct: 129 CHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLA--IEVQGDHQAWF-GFAGTPGYLSP 185 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 E++ + Y KS+DIW+ G IL +L P F + + I Sbjct: 186 EVL-KKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI---------------- 228 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 KA Y P W + P +A +L+++MLT NPNKRIT EAL HP++ Q Sbjct: 229 --KAGAYDYPSPE-----WDTVTP----EAKNLINQMLTVNPNKRITAAEALKHPWICQ 276 >4YZB-A nrPDB Length = 491 Score = 266 bits (681), Expect = 1e-71, Method: Composition-based stats. Identities = 86/358 (24%), Positives = 151/358 (42%), Gaps = 48/358 (13%) Query: 10 GGGEPRRT-EGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRV 68 G G P + PG V+ RY + +G+G++G V D V Sbjct: 1 GPGSPAASKSDKLAATPGMF--VQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEY 58 Query: 69 AIKKISPFE--HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQD-LM 125 A+K IS + +T + L+E+++L + H N++ + + E Y+V + Sbjct: 59 AVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFF-----EDKGYFYLVTEVYT 113 Query: 126 ETDLYK-LLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT---TCDLK 181 +L+ ++ ++ S + Q+L G+ Y+H ++HRDLKP NLL+ +++ Sbjct: 114 GGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIR 173 Query: 182 ICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN 241 I DFGL+ + T + + + T +Y APE++ + Y + D+WS G IL +LS Sbjct: 174 IIDFGLSTHF----ESTKKMKDKIGTAYYIAPEVLHGT--YDEKCDVWSTGVILYILLSG 227 Query: 242 RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDS 301 P F G + D L + + + LP KV Sbjct: 228 CPPFNGANEFDILKKV------------------EKGKFTFDLPQWKKV---------SE 260 Query: 302 KALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKER 359 A DL+ +ML + P RI+ +AL H +L+ TD + + + + Sbjct: 261 PAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSIDVPSLESTILNIRQFQGTQ 318 >3MN3-A nrPDB Length = 271 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 76/303 (25%), Positives = 127/303 (41%), Gaps = 43/303 (14%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP--FEHQTYCQRTLREIQILLRFRHE 98 Y ++ +GEG++G V AY +VA+K I+ R REI L RH Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL-KSQQLSNDHICYFLYQILRGLKYI 157 ++I + D+++ + ++ +V + +L+ + + ++S F QI+ ++Y Sbjct: 65 HIIKLYDVIK-----SKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYC 119 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 H ++HRDLKP NLL++ ++KI DFGL+ I + FL + Y APE++ Sbjct: 120 HRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGN----FLKTSCGSPNYAAPEVIS 175 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 +D+WS G IL ML R F + +I Sbjct: 176 GKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNIS------------------- 216 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 N + +LP A L+ RML NP RI++ E + + + Sbjct: 217 -NGVYTLPKF-----------LSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVDLPEY 264 Query: 338 DEP 340 P Sbjct: 265 LLP 267 >4REW-A nrPDB Length = 540 Score = 264 bits (676), Expect = 3e-71, Method: Composition-based stats. Identities = 79/327 (24%), Positives = 130/327 (39%), Gaps = 49/327 (14%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHE 98 Y +G G +G V + +VA+K ++ + REIQ L FRH Sbjct: 7 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 66 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL-KSQQLSNDHICYFLYQILRGLKY 156 ++I + ++ + D+++V + + +L+ + K+ +L QIL G+ Y Sbjct: 67 HIIKLYQVISTPS-----DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 121 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 H V+HRDLKP N+L++ + KI DFGL+ + FL + Y APE++ Sbjct: 122 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE----FLRTSCGSPNYAAPEVI 177 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 +DIWS G IL +L F H I + Q Sbjct: 178 SGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQ---------- 227 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 + + LL ML +P KR ++++ H + +Q D Sbjct: 228 ---------------------YLNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ--DL 264 Query: 337 TDEPVAEEPFTFAMELDDLPKERLKEL 363 E+P + +DD E LKE+ Sbjct: 265 PKYLFPEDPSYSSTMIDD---EALKEV 288 >2VN9-A nrPDB Length = 301 Score = 264 bits (675), Expect = 4e-71, Method: Composition-based stats. Identities = 80/300 (26%), Positives = 130/300 (43%), Gaps = 42/300 (14%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRH 97 Y + +G+GA+ +V A K I+ + Q+ RE +I +H Sbjct: 3 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLY-KLLKSQQLSNDHICYFLYQILRGLK 155 N++ + D + Y+V DL+ +L+ ++ + S + + QIL + Sbjct: 63 PNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 117 Query: 156 YIHSANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 + H ++HRDLKP NLL+ + +K+ DFGLA + + D + + T Y + Sbjct: 118 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA--IEVQGDQQAWF-GFAGTPGYLS 174 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++ Y K +D+W+ G IL +L P F + I Sbjct: 175 PEVL-RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQI--------------- 218 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 KA Y P W + P +A DL+++MLT NP KRIT EAL HP++ Q Sbjct: 219 ---KAGAYDFPSPE-----WDTVTP----EAKDLINKMLTINPAKRITASEALKHPWICQ 266 >4FG9-A nrPDB Length = 320 Score = 263 bits (673), Expect = 7e-71, Method: Composition-based stats. Identities = 77/303 (25%), Positives = 129/303 (42%), Gaps = 42/303 (13%) Query: 33 GQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQIL 92 Q D+ Y +G GA+ V A D + VAIK I+ + EI +L Sbjct: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVL 70 Query: 93 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQL-SNDHICYFLYQI 150 + +H N++ + DI + +Y++ L+ +L+ + + + ++Q+ Sbjct: 71 HKIKHPNIVALDDIYESGG-----HLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQV 125 Query: 151 LRGLKYIHSANVLHRDLKPSNLL---INTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 L +KY+H ++HRDLKP NLL ++ + I DFGL+++ DP L+ T Sbjct: 126 LDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPG----SVLSTACGT 181 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 Y APE++ K Y+K++D WS+G I +L P F ++ IL Sbjct: 182 PGYVAPEVLAQ-KPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKA------- 233 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAH 327 Y P A D + ++ +P KR T E+AL H Sbjct: 234 -----------EYEFDSPYWD---------DISDSAKDFIRHLMEKDPEKRFTCEQALQH 273 Query: 328 PYL 330 P++ Sbjct: 274 PWI 276 >3E3P-A nrPDB Length = 360 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 100/334 (29%), Positives = 163/334 (48%), Gaps = 26/334 (7%) Query: 21 GPGVPGEVEMVKGQPF---DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE 77 GPG + R+ + G+G +G V + VAIKK+ + Sbjct: 1 GPGSMMSLNAAAAADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV--IQ 58 Query: 78 HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI--VQDLMETDLYKLLKS 135 + R L+ +Q L H N++ ++ RD+Y+ V + + L++ ++ Sbjct: 59 DPRFRNRELQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRN 118 Query: 136 QQL-----SNDHICYFLYQILRGLKYIH--SANVLHRDLKPSNLLINT-TCDLKICDFGL 187 I FL+Q++R + +H S NV HRD+KP N+L+N LK+CDFG Sbjct: 119 YYRRQVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGS 178 Query: 188 ARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 247 A+ P + Y+ +R+YRAPE++ ++ YT ++DIWSVGCI AEM+ PIF G Sbjct: 179 AKKLSPSEPNVA----YICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRG 234 Query: 248 KHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD----SKA 303 + QL+ I+ +LG PS+E L + + L + + W+ +F +A Sbjct: 235 DNSAGQLHEIVRVLGCPSREVLR---KLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEA 291 Query: 304 LDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 DLL +L + P +R+ EAL HPY ++ +DP Sbjct: 292 YDLLSALLQYLPEERMKPYEALCHPYFDELHDPA 325 >2JC6-A nrPDB Length = 334 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 73/307 (23%), Positives = 125/307 (40%), Gaps = 42/307 (13%) Query: 29 EMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLRE 88 K Q D+ + + +G GA+ V A + A+K I + E Sbjct: 11 SSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENE 70 Query: 89 IQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQL-SNDHICYF 146 I +L + +HEN++ + DI E+ +Y+V L+ +L+ + + + Sbjct: 71 IAVLRKIKHENIVALEDIY-----ESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTL 125 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLI---NTTCDLKICDFGLARIADPEHDHTGFLTE 203 + Q+L + Y+H ++HRDLKP NLL + + I DFGL+++ ++ Sbjct: 126 IRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM----EGKGDVMST 181 Query: 204 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS 263 T Y APE++ K Y+K++D WS+G I +L P F ++ IL Sbjct: 182 ACGTPGYVAPEVLAQ-KPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKA--- 237 Query: 264 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEE 323 Y P A D + ++ +PNKR T E+ Sbjct: 238 ---------------EYEFDSPYWD---------DISDSAKDFIRNLMEKDPNKRYTCEQ 273 Query: 324 ALAHPYL 330 A HP++ Sbjct: 274 AARHPWI 280 >3H4J-B nrPDB Length = 336 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 80/310 (25%), Positives = 136/310 (43%), Gaps = 48/310 (15%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP--FEHQTYCQRTLREIQILLR 94 +GP Y + +GEG++G V A + + +VA+K IS + R REI L Sbjct: 7 HIGP-YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKL 65 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL-KSQQLSNDHICYFLYQILRG 153 RH ++I + D++ T D+ +V + +L+ + + ++++ D F QI+ Sbjct: 66 LRHPHIIKLYDVITTPT-----DIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICA 120 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 ++Y H ++HRDLKP NLL++ ++KI DFGL+ I + FL + Y AP Sbjct: 121 IEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGN----FLKTSCGSPNYAAP 176 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 E++ +D+WS G +L ML R F E + + Sbjct: 177 EVINGKLYAGPEVDVWSCGIVLYVMLVGRLPF-------------------DDEFIPNLF 217 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE-- 331 K + + +P A L+ RM+ +P +RIT++E P+ Sbjct: 218 K-KVNSCVYVMPDF-----------LSPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVN 265 Query: 332 --QYYDPTDE 339 Y P +E Sbjct: 266 LPDYLRPMEE 275 >4CQG-A nrPDB Length = 331 Score = 261 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 78/317 (24%), Positives = 127/317 (40%), Gaps = 40/317 (12%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 ++ Y + IG G + V A + VAIK + + R EI L R Sbjct: 6 ELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLR 65 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQ-QLSNDHICYFLYQILRGL 154 H+++ + +L E +++V + +L+ + SQ +LS + QIL + Sbjct: 66 HQHICQLYHVL-----ETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAV 120 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 Y+HS HRDLKP NLL + LK+ DFGL A P+ + L E + Y APE Sbjct: 121 AYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLC--AKPKGNKDYHLQECCGSLAYAAPE 178 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 ++ D+WS+G +L ++ F + + I+ Sbjct: 179 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMR--------------- 223 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 334 +P ++ LL +ML +P KRI++ L HP++ Q Y Sbjct: 224 -----GKYEVPKW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDY 267 Query: 335 DPTDEPVAEEPFTFAME 351 E ++ P T E Sbjct: 268 SCPVEWQSKTPLTHLDE 284 >3KK8-A nrPDB Length = 284 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 79/300 (26%), Positives = 133/300 (44%), Gaps = 43/300 (14%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRF 95 Y + +G+GA+ +V A K I+ + Q+ RE +I + Sbjct: 3 KFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKL 62 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQL-SNDHICYFLYQILRG 153 +H N++ + D ++ + Y+V DL+ +L++ + +++ S + + QIL Sbjct: 63 QHPNIVRLHDSIQEESFH-----YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILES 117 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWY 210 + Y HS ++HR+LKP NLL+ + +K+ DFGLA E + + + T Y Sbjct: 118 IAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLA----IEVNDSEAWHGFAGTPGY 173 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 +PE++ Y+K +DIW+ G IL +L P F + I Sbjct: 174 LSPEVL-KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI------------- 219 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 KA Y P W + P +A L+D MLT NP KRIT ++AL P++ Sbjct: 220 -----KAGAYDYPSPE-----WDTVTP----EAKSLIDSMLTVNPKKRITADQALKVPWI 265 >2V7O-A nrPDB Length = 336 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 80/300 (26%), Positives = 135/300 (45%), Gaps = 42/300 (14%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRH 97 Y + +G+GA+ +V A K I+ + Q+ RE +I +H Sbjct: 30 TDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKH 89 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLY-KLLKSQQLSNDHICYFLYQILRGLK 155 N++ + D + Y+V DL+ +L+ ++ + S + ++QIL + Sbjct: 90 PNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVN 144 Query: 156 YIHSANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 +IH +++HRDLKP NLL+ + C +K+ DFGLA + + + + + T Y + Sbjct: 145 HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA--IEVQGEQQAWF-GFAGTPGYLS 201 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++ Y K +DIW+ G IL +L P F + I Sbjct: 202 PEVL-RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI--------------- 245 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 KA Y P W + P +A +L+++MLT NP KRIT ++AL HP++ Q Sbjct: 246 ---KAGAYDFPSPE-----WDTVTP----EAKNLINQMLTINPAKRITADQALKHPWVCQ 293 >5YKS-A nrPDB Length = 377 Score = 261 bits (666), Expect = 5e-70, Method: Composition-based stats. Identities = 79/357 (22%), Positives = 148/357 (41%), Gaps = 50/357 (14%) Query: 20 VGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQ 79 GP + G +G + Y + +G G + +V A +VA+K I + Sbjct: 18 QGPHMAG---FKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLD 74 Query: 80 TYCQ-RTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLL--KS 135 T +E++ + +H N++ + +++ T +Y++ +L + D++ + Sbjct: 75 TLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQT-----KLYLILELGDGGDMFDYIMKHE 129 Query: 136 QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNL-LINTTCDLKICDFGLARIADPE 194 + L+ D + QI+ + Y H +V+HRDLKP N+ +K+ DFG + P Sbjct: 130 EGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPG 189 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 LT + Y APEI+L + ++DIWS+G IL ++ +P F + + L Sbjct: 190 KK----LTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETL 245 Query: 255 NHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFN 314 I+ + ++PS + DL+ RML + Sbjct: 246 TMIM--------------------DCKYTVPS-----------HVSKECKDLITRMLQRD 274 Query: 315 PNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKER-LKELIFQETAR 370 P +R ++EE HP+L Q DP+ P L + ++ ++ + A Sbjct: 275 PKRRASLEEIENHPWL-QGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIAD 330 >5U6Y-A nrPDB Length = 461 Score = 261 bits (666), Expect = 5e-70, Method: Composition-based stats. Identities = 79/297 (26%), Positives = 131/297 (44%), Gaps = 42/297 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENV 100 Y + +G+GA+ +V + A K I+ + Q+ RE +I +H N+ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 101 IGIRDILRASTLEAMRDVYIVQDLM-ETDLY-KLLKSQQLSNDHICYFLYQILRGLKYIH 158 + + D + Y++ DL+ +L+ ++ + S + + QIL + + H Sbjct: 62 VRLHDSISEEGHH-----YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 116 Query: 159 SANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 V+HRDLKP NLL+ + +K+ DFGLA + E + + + T Y +PE+ Sbjct: 117 QMGVVHRDLKPENLLLASKLKGAAVKLADFGLA--IEVEGEQQAWF-GFAGTPGYLSPEV 173 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + Y K +D+W+ G IL +L P F + I Sbjct: 174 L-RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI------------------ 214 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 KA Y P W + P +A DL+++MLT NP+KRIT EAL HP++ Sbjct: 215 KAGAYDFPSPE-----WDTVTP----EAKDLINKMLTINPSKRITAAEALKHPWISH 262 >5ES1-A nrPDB Length = 328 Score = 260 bits (665), Expect = 6e-70, Method: Composition-based stats. Identities = 73/310 (23%), Positives = 131/310 (42%), Gaps = 43/310 (13%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHEN 99 Y L+ IG+G + V A + VAIK I + + + Q+ RE++I+ H N Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPN 75 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQ-QLSNDHICYFLYQILRGLKYI 157 ++ + +++ E + +Y+V + +++ L S ++ QI+ + Y Sbjct: 76 IVKLFEVI-----ETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYC 130 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 H N++HRDLK NLL++ ++KI DFG + E L + + Y APE+ Sbjct: 131 HQKNIVHRDLKAENLLLDAEANIKIADFGFS----NEFTLGSKLDTFCGSPPYAAPELFQ 186 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 K +DIWS+G IL ++S F G + + +L Sbjct: 187 GKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLR------------------ 228 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 +P + +D +++ L R L NP KR T+E+ + ++ Y+ Sbjct: 229 --GKYRVP---------FYMSTDCESI--LRRFLVLNPAKRCTLEQIMKDKWINIGYEGE 275 Query: 338 DEPVAEEPFT 347 + EP Sbjct: 276 ELKPYTEPEE 285 >4CFH-A nrPDB Length = 493 Score = 260 bits (664), Expect = 9e-70, Method: Composition-based stats. Identities = 80/327 (24%), Positives = 130/327 (39%), Gaps = 49/327 (14%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHE 98 Y +G G +G V + +VA+K ++ + REIQ L FRH Sbjct: 34 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 93 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL-KSQQLSNDHICYFLYQILRGLKY 156 ++I + ++ + D+++V + + +L+ + K+ +L QIL G+ Y Sbjct: 94 HIIKLYQVISTPS-----DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 148 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 H V+HRDLKP N+L++ + KI DFGL+ + FL + Y APE++ Sbjct: 149 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE----FLRTSCGSPNYAAPEVI 204 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 +DIWS G IL +L F H I + Q Sbjct: 205 SGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQ---------- 254 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 + + LL ML +P KR T+++ H + +Q D Sbjct: 255 ---------------------YLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQ--DL 291 Query: 337 TDEPVAEEPFTFAMELDDLPKERLKEL 363 E+P + +DD E LKE+ Sbjct: 292 PKYLFPEDPSYSSTMIDD---EALKEV 315 >3BHH-A nrPDB Length = 295 Score = 260 bits (664), Expect = 9e-70, Method: Composition-based stats. Identities = 83/300 (27%), Positives = 132/300 (44%), Gaps = 42/300 (14%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRH 97 Y + IG+GA+ +V A K I+ + Q+ RE +I +H Sbjct: 3 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLY-KLLKSQQLSNDHICYFLYQILRGLK 155 N++ + D + Y+V DL+ +L+ ++ + S + + QIL + Sbjct: 63 SNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 117 Query: 156 YIHSANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 + H V+HRDLKP NLL+ + C +K+ DFGLA + + D + + T Y + Sbjct: 118 HCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA--IEVQGDQQAWF-GFAGTPGYLS 174 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++ + Y K +DIW+ G IL +L P F + I Sbjct: 175 PEVL-RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI--------------- 218 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 KA Y P W + P +A +L+++MLT NP KRIT EAL HP++ Q Sbjct: 219 ---KAGAYDFPSPE-----WDTVTP----EAKNLINQMLTINPAKRITAHEALKHPWVCQ 266 >4D2V-A nrPDB Length = 356 Score = 260 bits (664), Expect = 9e-70, Method: Composition-based stats. Identities = 82/344 (23%), Positives = 135/344 (39%), Gaps = 51/344 (14%) Query: 19 GVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEH 78 G + E++K Y + IG G + V A + VAIK + Sbjct: 16 PRGSHMKDYDELLKY--------YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTL 67 Query: 79 QTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQ- 136 + R EI+ L RH+++ + +L E +++V + +L+ + SQ Sbjct: 68 GSDLPRIKTEIEALKNLRHQHICQLYHVL-----ETANKIFMVLEYCPGGELFDYIISQD 122 Query: 137 QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 +LS + QI+ + Y+HS HRDLKP NLL + LK+ DFGL A P+ + Sbjct: 123 RLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLC--AKPKGN 180 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 L Y APE++ D+WS+G +L ++ F + Sbjct: 181 KDYHLQACCGALAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAK 240 Query: 257 ILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPN 316 I+ +P ++ LL +ML +P Sbjct: 241 IMR--------------------GKYDVPKW-----------LSPSSILLLQQMLQVDPK 269 Query: 317 KRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL 360 KRI+++ L HP++ Q Y+ E ++ PF + LDD L Sbjct: 270 KRISMKNLLNHPWIMQDYNYPVEWQSKNPF---IHLDDDCVTEL 310 >4RED-A nrPDB Length = 351 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 79/327 (24%), Positives = 128/327 (39%), Gaps = 49/327 (14%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHE 98 Y +G G +G V + VA+K ++ + REIQ L FRH Sbjct: 15 HYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 74 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL-KSQQLSNDHICYFLYQILRGLKY 156 ++I + ++ + D+++V + + +L+ + K+ +L QIL G+ Y Sbjct: 75 HIIKLYQVISTPS-----DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 129 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 H V+HRDLKP N+L++ + KI DFGL+ + FL + Y APE++ Sbjct: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE----FLRTSCGSPNYAAPEVI 185 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 +DIWS G IL +L F H I + Q Sbjct: 186 SGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQ---------- 235 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 + + LL ML +P KR ++++ H + +Q D Sbjct: 236 ---------------------YLNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ--DL 272 Query: 337 TDEPVAEEPFTFAMELDDLPKERLKEL 363 E+P +DD E LKE+ Sbjct: 273 PKYLFPEDPSYSTTMIDD---EALKEV 296 >2QNJ-A nrPDB Length = 328 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 73/343 (21%), Positives = 143/343 (41%), Gaps = 55/343 (16%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHEN 99 Y L+ IG+G + V A + VAIK I + + T Q+ RE++I+ H N Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 72 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQ-QLSNDHICYFLYQILRGLKYI 157 ++ + +++ E + +Y++ + +++ L + ++ QI+ ++Y Sbjct: 73 IVKLFEVI-----ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 127 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 H ++HRDLK NLL++ ++KI DFG + E G L + + Y APE+ Sbjct: 128 HQKRIVHRDLKAENLLLDADMNIKIADFGFS----NEFTVGGKLDTFCGSPPYAAPELFQ 183 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 K +D+WS+G IL ++S F G++ + +L Sbjct: 184 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR------------------ 225 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 K ++ + + +LL R L NP KR T+E+ + ++ ++ Sbjct: 226 --------GKYRIPF-----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEED 272 Query: 338 D-EPVAEEPFTFAMELD-----------DLPKERLKELIFQET 368 + +P E + + + +E L ++ + E Sbjct: 273 ELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEI 315 >2VZ6-A nrPDB Length = 313 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 79/297 (26%), Positives = 131/297 (44%), Gaps = 42/297 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENV 100 Y + +G+GA+ +V + A K I+ + Q+ RE +I +H N+ Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 101 IGIRDILRASTLEAMRDVYIVQDLM-ETDLY-KLLKSQQLSNDHICYFLYQILRGLKYIH 158 + + D + Y++ DL+ +L+ ++ + S + + QIL + + H Sbjct: 84 VRLHDSISEEGHH-----YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 138 Query: 159 SANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 V+HRDLKP NLL+ + +K+ DFGLA + E + + + T Y +PE+ Sbjct: 139 QMGVVHRDLKPENLLLASKLKGAAVKLADFGLA--IEVEGEQQAWF-GFAGTPGYLSPEV 195 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + Y K +D+W+ G IL +L P F + I Sbjct: 196 L-RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI------------------ 236 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 KA Y P W + P +A DL+++MLT NP+KRIT EAL HP++ Sbjct: 237 KAGAYDFPSPE-----WDTVTP----EAKDLINKMLTINPSKRITAAEALKHPWISH 284 >5Y86-A nrPDB Length = 588 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 95/333 (28%), Positives = 157/333 (47%), Gaps = 43/333 (12%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 + RY L+ IG+G++G V+ YDH + VA+K + + + ++ EI+IL + Sbjct: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN--EKRFHRQAAEEIRILEHLK 261 Query: 97 HENVIGIRDILRA-STLEAMRDVYIVQDLMETDLYKLLKS---QQLSNDHICYFLYQILR 152 ++ G +++ + V + +L+ DLY+L+K Q S + F IL+ Sbjct: 262 KQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ 321 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWY 210 L +H ++H DLKP N+L+ K+ DFG + L Y+ +R+Y Sbjct: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF------EYQKLYTYIQSRFY 375 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 RAPEI+L S+ Y+ IDIWS GCILAE+L+ +P+FPG+ DQL ++ +LG P + L Sbjct: 376 RAPEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 Query: 271 CIINMKA----------------------------RNYLQSLPSKTKVAWAKLFPKSDSK 302 K R + P +K L D Sbjct: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 Query: 303 ALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 ++ L R L ++P+ R+T +AL HP++ + Sbjct: 495 FIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527 >5IG1-A nrPDB Length = 344 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 80/322 (24%), Positives = 138/322 (42%), Gaps = 46/322 (14%) Query: 21 GPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQ 79 GP + E D+ + IG+GA+ V + A+K I+ Sbjct: 1 GPHMETETSFFDLYDVDLKDK---RSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRS 57 Query: 80 TYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQL 138 + + REI I +HE+++ +R R + Y+V + + +L+ + +++ Sbjct: 58 SEINKIKREIGICSSLQHEHIVSMRRAFRDES-----HFYLVFEYVSGGELFDEIVTRKF 112 Query: 139 -SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLI---NTTCDLKICDFGLARIADPE 194 + ++QIL L++ HS N++HRDLKP NLL+ + +KI DFGLA I + Sbjct: 113 YNEKDASACMHQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQG 172 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 + G + T Y +PE++ Y ++D+W+ G IL +L P F + + Sbjct: 173 PTYFG----FAGTPGYLSPEVI-RRVPYDTAVDVWACGVILYILLVGYPPFWEEDHQKLY 227 Query: 255 NHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFN 314 I +N PS W + + A +L+ ML N Sbjct: 228 AQI--------------------KNCQYDFPSPE---WDSV----TTAAKELIKAMLEPN 260 Query: 315 PNKRITVEEALAHPYLEQYYDP 336 P +R TV+E L HP++ + P Sbjct: 261 PKRRPTVQELLQHPWIARRDVP 282 >4CFF-A nrPDB Length = 571 Score = 257 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 78/324 (24%), Positives = 127/324 (39%), Gaps = 46/324 (14%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHE 98 Y +G G +G V + +VA+K ++ + REIQ L FRH Sbjct: 34 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 93 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL-KSQQLSNDHICYFLYQILRGLKY 156 ++I + ++ T D ++V + + +L+ + K ++ QIL + Y Sbjct: 94 HIIKLYQVISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 148 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 H V+HRDLKP N+L++ + KI DFGL+ + FL + Y APE++ Sbjct: 149 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE----FLRTSCGSPNYAAPEVI 204 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 +DIWS G IL +L F +H I Sbjct: 205 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI------------------- 245 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 R + +P + A LL ML +P KR T+++ H + +Q D Sbjct: 246 -RGGVFYIPEYLNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQ--DL 291 Query: 337 TDEPVAEEPFTFAMELDDLPKERL 360 E+P A +DD + + Sbjct: 292 PSYLFPEDPSYDANVIDDEAVKEV 315 >4D28-A nrPDB Length = 446 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 77/308 (25%), Positives = 126/308 (40%), Gaps = 43/308 (13%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFRHE 98 +Y + IGEG + V A + VAIK ++ + REI I+ RH Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYK-LLKSQQLSNDHICYFLYQILRGLKY 156 N++ + ++L + + +YIV + + +L+ ++ +L D + Q++ + + Sbjct: 70 NIVRLYEVLASKS-----KIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAH 124 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 HS V HRDLKP NLL++T +LK+ DFGL+ + + L + T Y APE++ Sbjct: 125 CHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSAL---PQEGVELLNDTCGTPNYVAPEVL 181 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + DIWS G IL +L+ F Sbjct: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETD--------------------------- 214 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 L L K A P ++ L+ R+L NP RI ++ P+ + Y P Sbjct: 215 ----LPGLYRKINAAEFDCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVP 270 Query: 337 TDEPVAEE 344 EE Sbjct: 271 IRAREEEE 278 >5EZV-A nrPDB Length = 560 Score = 257 bits (657), Expect = 6e-69, Method: Composition-based stats. Identities = 78/324 (24%), Positives = 127/324 (39%), Gaps = 46/324 (14%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHE 98 Y +G G +G V + +VA+K ++ + REIQ L FRH Sbjct: 29 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 88 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL-KSQQLSNDHICYFLYQILRGLKY 156 ++I + ++ T D ++V + + +L+ + K ++ QIL + Y Sbjct: 89 HIIKLYQVISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 143 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 H V+HRDLKP N+L++ + KI DFGL+ + FL + Y APE++ Sbjct: 144 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE----FLRTSCGSPNYAAPEVI 199 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 +DIWS G IL +L F +H I Sbjct: 200 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI------------------- 240 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 R + +P + A LL ML +P KR T+++ H + +Q D Sbjct: 241 -RGGVFYIPEYLNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQ--DL 286 Query: 337 TDEPVAEEPFTFAMELDDLPKERL 360 E+P A +DD + + Sbjct: 287 PSYLFPEDPSYDANVIDDEAVKEV 310 >5ZTN-A nrPDB Length = 429 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 102/368 (27%), Positives = 165/368 (44%), Gaps = 52/368 (14%) Query: 1 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60 + A QG GG G + V+ V RY L+ IG+G++G V AY Sbjct: 63 LNAKKRQGMTGG-----PNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAY 117 Query: 61 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH---ENVIGIRDILRASTLEAMRD 117 DH VA+K + + + ++ EI+IL R +N + + +L T Sbjct: 118 DHKVHQHVALKMVRN--EKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFR--NH 173 Query: 118 VYIVQDLMETDLYKLLKS---QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLI 174 + + +L+ +LY+L+K Q S + F + IL+ L +H ++H DLKP N+L+ Sbjct: 174 ICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILL 233 Query: 175 NTTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVG 232 +K+ DFG + + Y+ +R+YRAPE++L ++ Y ID+WS+G Sbjct: 234 KQQGRSGIKVIDFGSSCYEHQ------RVYTYIQSRFYRAPEVILGAR-YGMPIDMWSLG 286 Query: 233 CILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLP------- 285 CILAE+L+ P+ PG+ DQL ++ +LG PSQ+ L+ K + P Sbjct: 287 CILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT 346 Query: 286 --------------------SKTKVAWAKLFPK-SDSKALDLLDRMLTFNPNKRITVEEA 324 W D LD L + L ++P R+T +A Sbjct: 347 LSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQA 406 Query: 325 LAHPYLEQ 332 L HP+L + Sbjct: 407 LRHPWLRR 414 >2JAM-A nrPDB Length = 304 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 74/305 (24%), Positives = 129/305 (42%), Gaps = 44/305 (14%) Query: 32 KGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQI 91 Q ++ + ++ +G GA+ V + A+K I EI + Sbjct: 1 SMQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSS-LENEIAV 59 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYK-LLKSQQLSNDHICYFLYQ 149 L + +HEN++ + DI ++T Y+V L+ +L+ +L+ + + Q Sbjct: 60 LKKIKHENIVTLEDIYESTT-----HYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQ 114 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLI---NTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 +L +KY+H ++HRDLKP NLL + I DFGL+++ + G ++ Sbjct: 115 VLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM-----EQNGIMSTACG 169 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 T Y APE++ K Y+K++D WS+G I +L P F + I Sbjct: 170 TPGYVAPEVLAQ-KPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKI--------- 219 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 K Y P + A D + +L +PN+R T E+AL+ Sbjct: 220 ---------KEGYYEFESP---------FWDDISESAKDFICHLLEKDPNERYTCEKALS 261 Query: 327 HPYLE 331 HP+++ Sbjct: 262 HPWID 266 >3EB0-A nrPDB Length = 383 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 98/336 (29%), Positives = 170/336 (50%), Gaps = 52/336 (15%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 +Y+ + +G G++G+V +D R A+KK+ + Y RE+ I+ H N Sbjct: 7 KKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKV--LQDPRYKN---RELDIMKVLDHVN 61 Query: 100 VIGIRDILRASTLEAMR---------------------------------DVYIVQDLME 126 +I + D + E + + ++ + + Sbjct: 62 IIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVP 121 Query: 127 TDLYKLLKS-----QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDL 180 L+K+LKS + + + I ++YQ+ R + +IHS + HRD+KP NLL+N+ L Sbjct: 122 DTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTL 181 Query: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240 K+CDFG A+ P Y+ +R+YRAPE+ML + YT SID+WS+GC+ E++ Sbjct: 182 KLCDFGSAKKLIPSEPSVA----YICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELIL 237 Query: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPK-S 299 +P+F G+ +DQL I+ I+G+P++E + I M P+ W K+ P+ + Sbjct: 238 GKPLFSGETSIDQLVRIIQIMGTPTKEQM---IRMNPHYTEVRFPTLKAKDWRKILPEGT 294 Query: 300 DSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 S A+DLL+++L + P+ RI EA+AHP+ + + Sbjct: 295 PSLAIDLLEQILRYEPDLRINPYEAMAHPFFDHLRN 330 >5KZ7-A nrPDB Length = 346 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 68/311 (21%), Positives = 134/311 (43%), Gaps = 48/311 (15%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHEN 99 Y L+ IG+G + V A + VA+K I + + + Q+ RE++I+ H N Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 93 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQ-QLSNDHICYFLYQILRGLKYI 157 ++ + +++ E + +Y+V + +++ L + ++ QI+ ++Y Sbjct: 94 IVKLFEVI-----ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 148 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 H ++HRDLK NLL++ ++KI DFG + E L + + Y APE+ Sbjct: 149 HQKFIVHRDLKAENLLLDADMNIKIADFGFS----NEFTFGNKLDTFCGSPPYAAPELFQ 204 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 K +D+WS+G IL ++S F G++ + +L Sbjct: 205 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR------------------ 246 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD-- 335 K ++ + + +LL + L NP+KR T+E+ + ++ ++ Sbjct: 247 --------GKYRIPF-----YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDD 293 Query: 336 ---PTDEPVAE 343 P EP+ + Sbjct: 294 ELKPYVEPLPD 304 >4CZT-A nrPDB Length = 464 Score = 254 bits (649), Expect = 5e-68, Method: Composition-based stats. Identities = 77/319 (24%), Positives = 126/319 (39%), Gaps = 47/319 (14%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFRHE 98 +Y + +GEG + V A + VAIK I + + REI + +H Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 71 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKS-QQLSNDHICYFLYQILRGLKY 156 NVI + +++ + T +Y V + + +L+ + S +L D + Q++ + Y Sbjct: 72 NVIRMFEVMASKT-----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 126 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 HS V HRDLKP NLL++ LK+ DFGL+ + G L T Y APE++ Sbjct: 127 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSA-LPQQVREDGLLHTTCGTPNYVAPEVI 185 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 N D+WS G IL +++ F + I + Sbjct: 186 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP----------- 234 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 P + A L+ R+L NP RIT E + + + ++ Y Sbjct: 235 --------------------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYK- 273 Query: 337 TDEPVAEEPFTFAMELDDL 355 A + + LDD+ Sbjct: 274 -----APKFENADVSLDDV 287 >2YCR-A nrPDB Length = 323 Score = 254 bits (648), Expect = 6e-68, Method: Composition-based stats. Identities = 88/312 (28%), Positives = 143/312 (45%), Gaps = 50/312 (16%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-------HQTYCQRTLR 87 P + Y + +G GA G V A++ +VAIK IS + Sbjct: 5 PKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVET 64 Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICY 145 EI+IL + H +I I++ D YIV +LME +L+ ++ +++L Sbjct: 65 EIEILKKLNHPCIIKIKNFF------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKL 118 Query: 146 FLYQILRGLKYIHSANVLHRDLKPSNLLIN---TTCDLKICDFGLARIADPEHDHTGFLT 202 + YQ+L ++Y+H ++HRDLKP N+L++ C +KI DFG ++I T + Sbjct: 119 YFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL----GETSLMR 174 Query: 203 EYVATRWYRAPEIM--LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI 260 T Y APE++ + + GY +++D WS+G IL LS P F Sbjct: 175 TLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFS-------------- 220 Query: 261 LGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT 320 +Q L I N++ +++ + KALDL+ ++L +P R T Sbjct: 221 -EHRTQVSLKDQITSGKYNFI-----------PEVWAEVSEKALDLVKKLLVVDPKARFT 268 Query: 321 VEEALAHPYLEQ 332 EEAL HP+L+ Sbjct: 269 TEEALRHPWLQD 280 >3SOA-A nrPDB Length = 444 Score = 253 bits (647), Expect = 7e-68, Method: Composition-based stats. Identities = 77/300 (25%), Positives = 130/300 (43%), Gaps = 42/300 (14%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRH 97 Y + +G+GA+ +V + A I+ + Q+ RE +I +H Sbjct: 10 TEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH 69 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLY-KLLKSQQLSNDHICYFLYQILRGLK 155 N++ + D + Y++ DL+ +L+ ++ + S + + QIL + Sbjct: 70 PNIVRLHDSISEEGHH-----YLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 124 Query: 156 YIHSANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 + H V+HR+LKP NLL+ + +K+ DFGLA + E + + + T Y + Sbjct: 125 HCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLA--IEVEGEQQAWF-GFAGTPGYLS 181 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++ Y K +D+W+ G IL +L P F + I Sbjct: 182 PEVL-RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI--------------- 225 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 KA Y P W + P +A DL+++MLT NP+KRIT EAL HP++ Sbjct: 226 ---KAGAYDFPSPE-----WDTVTP----EAKDLINKMLTINPSKRITAAEALKHPWISH 273 >5WAX-A nrPDB Length = 310 Score = 253 bits (647), Expect = 7e-68, Method: Composition-based stats. Identities = 82/333 (24%), Positives = 129/333 (38%), Gaps = 44/333 (13%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 G RY ++ IG G +G+ + VA+K I E + REI R Sbjct: 8 HDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKID--ENVQREIINHRSLR 65 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYK-LLKSQQLSNDHICYFLYQILRGL 154 H N+I ++++ T A IV + +L++ + + + S D +F Q++ G+ Sbjct: 66 HPNIIRFKEVILTPTHLA-----IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 120 Query: 155 KYIHSANVLHRDLKPSNLLINTTC--DLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 Y HS V HRDLK N L++ + LKICDFG ++ + V T Y A Sbjct: 121 SYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLH----SQPKSTVGTPAYIA 176 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH-ILGILGSPSQEDLNC 271 PE++L + K D+WS G L ML F I ILG Sbjct: 177 PEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV-------- 228 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 S+P + DL+ R+ NP RIT+ E HP+ Sbjct: 229 ---------QYSIPDYV---------HISPECQDLISRIFVANPATRITIPEIRNHPWFL 270 Query: 332 QYYDPTDEPVAEEPFTFAMELDDLPKERLKELI 364 + + + + P + + E++ Sbjct: 271 KNLPADLMDDSTMSKQYEEP--EQPMQSMDEIM 301 >3COM-A nrPDB Length = 314 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 77/322 (23%), Positives = 133/322 (41%), Gaps = 46/322 (14%) Query: 14 PRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI 73 R + + + QP +V + L+ +GEG+YG V A VAIK++ Sbjct: 6 QLRNPPRRQLKKLDEDSLTKQPEEV---FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV 62 Query: 74 SPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKL 132 ++ Q ++EI I+ + +V+ +T D++IV + + + Sbjct: 63 ---PVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNT-----DLWIVMEYCGAGSVSDI 114 Query: 133 --LKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARI 190 L+++ L+ D I L L+GL+Y+H +HRD+K N+L+NT K+ DFG+A Sbjct: 115 IRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQ 174 Query: 191 ADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHY 250 D + T ++ APE++ GY DIWS+G EM +P + H Sbjct: 175 LT---DTMAKRNTVIGTPFWMAPEVI-QEIGYNCVADIWSLGITAIEMAEGKPPYADIH- 229 Query: 251 LDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRM 310 + I I +P + W+ F D + + Sbjct: 230 --PMRAIFMIPTNPPPTF------------------RKPELWSDNF-------TDFVKQC 262 Query: 311 LTFNPNKRITVEEALAHPYLEQ 332 L +P +R T + L HP++ Sbjct: 263 LVKSPEQRATATQLLQHPFVRS 284 >3I6U-A nrPDB Length = 419 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 87/312 (27%), Positives = 143/312 (45%), Gaps = 50/312 (16%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-------HQTYCQRTLR 87 P + Y + +G GA G V A++ +VAI+ IS + Sbjct: 130 PKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVET 189 Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICY 145 EI+IL + H +I I++ D YIV +LME +L+ ++ +++L Sbjct: 190 EIEILKKLNHPCIIKIKNFF------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKL 243 Query: 146 FLYQILRGLKYIHSANVLHRDLKPSNLLIN---TTCDLKICDFGLARIADPEHDHTGFLT 202 + YQ+L ++Y+H ++HRDLKP N+L++ C +KI DFG ++I T + Sbjct: 244 YFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL----GETSLMR 299 Query: 203 EYVATRWYRAPEIM--LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI 260 T Y APE++ + + GY +++D WS+G IL LS P F Sbjct: 300 TLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFS-------------- 345 Query: 261 LGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT 320 +Q L I N++ +++ + KALDL+ ++L +P R T Sbjct: 346 -EHRTQVSLKDQITSGKYNFI-----------PEVWAEVSEKALDLVKKLLVVDPKARFT 393 Query: 321 VEEALAHPYLEQ 332 EEAL HP+L+ Sbjct: 394 TEEALRHPWLQD 405 >4NIF-A nrPDB Length = 333 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 86/307 (28%), Positives = 140/307 (45%), Gaps = 45/307 (14%) Query: 33 GQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQIL 92 G Y + IG G+Y A+K I + EI+IL Sbjct: 1 GSNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-----EIEIL 55 Query: 93 LRF-RHENVIGIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQ 149 LR+ +H N+I ++D+ + + VY+V +LM L K+L+ + S + L+ Sbjct: 56 LRYGQHPNIITLKDVY-----DDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHT 110 Query: 150 ILRGLKYIHSANVLHRDLKPSNLL-INTTCD---LKICDFGLARIADPEHDHTGFLTEYV 205 I + ++Y+HS V+HRDLKPSN+L ++ + + L+ICDFG A+ E+ G L Sbjct: 111 IGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAEN---GLLMTPC 167 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 T + APE++ +GY + DIWS+G +L ML+ F D IL +GS Sbjct: 168 YTANFVAPEVL-KRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGK 225 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 + W + A DL+ +ML +P++R+T ++ L Sbjct: 226 FTL-------------------SGGNWNTV----SETAKDLVSKMLHVDPHQRLTAKQVL 262 Query: 326 AHPYLEQ 332 HP++ Q Sbjct: 263 QHPWVTQ 269 >6FD3-A nrPDB Length = 300 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 132/296 (44%), Gaps = 39/296 (13%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 D +YT+ + IG+GA G V +A D VAIK+++ + Q + + EI ++ + Sbjct: 19 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN-LQQQPKKELIINEILVMRENK 77 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQLSNDHICYFLYQILRGLK 155 + N++ D + ++++V + + L ++ + I + L+ L Sbjct: 78 NPNIVNYLD-----SYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALD 132 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 ++HS V+HRD+K N+L+ +K+ DFG PE + V T ++ APE+ Sbjct: 133 FLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ---SKRSTMVGTPYWMAPEV 189 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + K Y +DIWS+G + EM+ P + ++ L L I G+P ++ Sbjct: 190 V-TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQNPE----- 242 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + + D L+R L + ++R + +E L HP+L+ Sbjct: 243 ----------------------RLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 276 >1PHK-A nrPDB Length = 298 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 87/310 (28%), Positives = 130/310 (41%), Gaps = 52/310 (16%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--------SPFEHQTYCQRTLREIQI 91 Y + +G G +V A+K I S E Q + TL+E+ I Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 92 LLRFR-HENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQ-QLSNDHICYFLY 148 L + H N+I ++D +T ++V DLM+ +L+ L + LS + Sbjct: 77 LRKVSGHPNIIQLKDTYETNTF-----FFLVFDLMKKGELFDYLTEKVTLSEKETRKIMR 131 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 +L + +H N++HRDLKP N+L++ ++K+ DFG + DP L E T Sbjct: 132 ALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEK----LREVCGTP 187 Query: 209 WYRAPEIML-----NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS 263 Y APEI+ N GY K +D+WS G I+ +L+ P F + + L I+ Sbjct: 188 SYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMS---- 243 Query: 264 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEE 323 NY P DL+ R L P KR T EE Sbjct: 244 --------------GNYQFGSPEWDDY---------SDTVKDLVSRFLVVQPQKRYTAEE 280 Query: 324 ALAHPYLEQY 333 ALAHP+ +QY Sbjct: 281 ALAHPFFQQY 290 >3DAK-A nrPDB Length = 290 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 73/311 (23%), Positives = 129/311 (41%), Gaps = 39/311 (12%) Query: 35 PFDVG-PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILL 93 P+ + Y + IG GA +V +AY +K +VAIK+I+ + QT L+EIQ + Sbjct: 4 PWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMS 63 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLK---------SQQLSNDHI 143 + H N++ ++ ++++V L+ + ++K S L I Sbjct: 64 QCHHPNIVSYY-----TSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTI 118 Query: 144 CYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD--HTGFL 201 L ++L GL+Y+H +HRD+K N+L+ ++I DFG++ D Sbjct: 119 ATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVR 178 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 261 +V T + APE+M +GY DIWS G E+ + + + L +L + Sbjct: 179 KTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVL--MLTLQ 236 Query: 262 GSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 321 P + + Y +S ++ L +P KR T Sbjct: 237 NDPPSLETGVQDKEMLKKYGKSF-------------------RKMISLCLQKDPEKRPTA 277 Query: 322 EEALAHPYLEQ 332 E L H + ++ Sbjct: 278 AELLRHKFFQK 288 >5KCV-A nrPDB Length = 460 Score = 250 bits (638), Expect = 8e-67, Method: Composition-based stats. Identities = 74/371 (19%), Positives = 142/371 (38%), Gaps = 58/371 (15%) Query: 3 AAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDH 62 AAA G P G EV + K + + L+ +G+G +G V + Sbjct: 128 AAAEMDFRSGSPSDNSG---AEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEK 184 Query: 63 VRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120 A+K + + TL E ++L RH + ++ + + + Sbjct: 185 ATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALK-----YSFQTHDRLCF 239 Query: 121 VQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGLKYIHS-ANVLHRDLKPSNLLINTT 177 V + + L + + S D ++ +I+ L Y+HS NV++RDLK NL+++ Sbjct: 240 VMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKD 299 Query: 178 CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE 237 +KI DFGL + + + + T Y APE++ ++ Y +++D W +G ++ E Sbjct: 300 GHIKITDFGLCKEGIKDG---ATMKTFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYE 355 Query: 238 MLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFP 297 M+ R F + + IL M+ + ++L Sbjct: 356 MMCGRLPFYNQDHEKLFELIL----------------MEEIRFPRTLG------------ 387 Query: 298 KSDSKALDLLDRMLTFNPNKRI-----TVEEALAHPYL-----EQYYDPTDEPVAEEPFT 347 +A LL +L +P +R+ +E + H + + Y+ P + T Sbjct: 388 ---PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVT 444 Query: 348 FAMELDDLPKE 358 + +E Sbjct: 445 SETDTRYFDEE 455 >5XZW-A nrPDB Length = 471 Score = 250 bits (638), Expect = 1e-66, Method: Composition-based stats. Identities = 81/334 (24%), Positives = 131/334 (39%), Gaps = 58/334 (17%) Query: 13 EPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKK 72 P T MV + + +G+GA+ V A + A+K Sbjct: 175 SPGLTSSTAS------SMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKI 228 Query: 73 ISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYK 131 IS + RE+++L + H ++ ++ E Y+V + + DL Sbjct: 229 ISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY-----EDTESYYMVMEFVSGGDLMD 283 Query: 132 LLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD--LKICDFGLA 188 + + + D QIL +KYIHS + HRDLKP N+LI +KI DFGLA Sbjct: 284 FVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLA 343 Query: 189 RIADPEHDHTGFLTEYVATRWYRAPEIMLNSKG------------YTKSIDIWSVGCILA 236 ++ + F+ + T Y APE++ Y+ +D+WS+GC++ Sbjct: 344 KV----QGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVY 399 Query: 237 EMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLF 296 +L+ F G DQL +G R P K Sbjct: 400 VILTGHLPFSG-STQDQLYKQIG------------------RGSYHEGPLKDF------- 433 Query: 297 PKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + +A D +D +L +PN R T +AL HP++ Sbjct: 434 -RISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >2Y7J-A nrPDB Length = 365 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 79/308 (25%), Positives = 131/308 (42%), Gaps = 51/308 (16%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIK-------KISPFEHQTYCQRTLREIQIL 92 +Y IG G +V A+K ++SP + + + T RE IL Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 93 LRFR-HENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ-LSNDHICYFLYQ 149 + H ++I + D +S+ +++V DLM +L+ L + LS + Sbjct: 154 RQVAGHPHIITLIDSYESSSF-----MFLVFDLMRKGELFDYLTEKVALSEKETRSIMRS 208 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW 209 +L + ++H+ N++HRDLKP N+L++ +++ DFG + +P L E T Sbjct: 209 LLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEK----LRELCGTPG 264 Query: 210 YRAPEIM-----LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP 264 Y APEI+ GY K +D+W+ G IL +L+ P F + + L I+ Sbjct: 265 YLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIME----- 319 Query: 265 SQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 Y S P S DL+ R+L +P R+T E+A Sbjct: 320 -------------GQYQFSSPEWDDR---------SSTVKDLISRLLQVDPEARLTAEQA 357 Query: 325 LAHPYLEQ 332 L HP+ E+ Sbjct: 358 LQHPFFER 365 >1U5R-A nrPDB Length = 348 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 85/334 (25%), Positives = 141/334 (42%), Gaps = 48/334 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY--CQRTLREIQILLRFRHEN 99 ++ L+ IG G++G V A D VAIKK+S Q+ Q ++E++ L + RH N Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL--KSQQLSNDHICYFLYQILRGLKYI 157 I R ++V + LL + L I + L+GL Y+ Sbjct: 116 TIQYRGCYLRE-----HTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYL 170 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 HS N++HRD+K N+L++ +K+ DFG A I P +V T ++ APE++L Sbjct: 171 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP-------ANSFVGTPYWMAPEVIL 223 Query: 218 --NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + Y +D+WS+G E+ +P + + L HI Sbjct: 224 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ---------------- 267 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 P+ W++ F + +D L P R T E L H ++ + Sbjct: 268 ------NESPALQSGHWSEYF-------RNFVDSCLQKIPQDRPTSEVLLKHRFVLRERP 314 Query: 336 PTD-EPVAEEPFTFAMELDDLPKERLKELIFQET 368 PT + + ELD+L ++K+++FQE Sbjct: 315 PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEA 348 >3F3Z-A nrPDB Length = 277 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 77/301 (25%), Positives = 124/301 (41%), Gaps = 44/301 (14%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 D+ YT IG G++G V A + R A KKI P R +EI+I+ Sbjct: 6 DINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKI-PKYFVEDVDRFKQEIEIMKSLD 64 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYK-LLKSQQLSNDHICYFLYQILRGL 154 H N+I + + T E D+Y+V +L +L++ ++ + + +L + Sbjct: 65 HPNIIRLYE-----TFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAV 119 Query: 155 KYIHSANVLHRDLKPSNLLI---NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 Y H NV HRDLKP N L + LK+ DFGLA P + V T +Y Sbjct: 120 AYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPG----KMMRTKVGTPYYV 175 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 +P+++ Y D WS G ++ +L P F + + I + ++D Sbjct: 176 SPQVLEG--LYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLN 233 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + +A L+ R+LT +P +RIT +AL H + E Sbjct: 234 V---------------------------SPQAESLIRRLLTKSPKQRITSLQALEHEWFE 266 Query: 332 Q 332 + Sbjct: 267 K 267 >4B6L-A nrPDB Length = 281 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 76/310 (24%), Positives = 127/310 (40%), Gaps = 44/310 (14%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILLRFR 96 G Y + + +G+G + A D + A+K I S ++ L EI++ + Sbjct: 8 GRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQ 67 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLK-SQQLSNDHICYFLYQILRGL 154 H +++ + E ++YI +L L + K L + Y+L QIL GL Sbjct: 68 HRHIVRF-----SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGL 122 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 KY+H +LHRDLK N I +LK+ DFGLA +P T Y APE Sbjct: 123 KYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRK---KTICGTPNYVAPE 179 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 ++L +G+ D+WS+GC++ +L P F + I + Sbjct: 180 VLL-RQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQV-------------- 224 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 334 +LP+ + A LL +L +P R ++++ L H + + Y Sbjct: 225 ------HYTLPASLSLP-----------ARQLLAAILRASPRDRPSIDQILRHDFFTKGY 267 Query: 335 DPTDEPVAEE 344 P P++ Sbjct: 268 TPDRLPISSC 277 >2GCD-A nrPDB Length = 309 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 85/334 (25%), Positives = 141/334 (42%), Gaps = 48/334 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY--CQRTLREIQILLRFRHEN 99 ++ L+ IG G++G V A D VAIKK+S Q+ Q ++E++ L + RH N Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL--KSQQLSNDHICYFLYQILRGLKYI 157 I R ++V + LL + L I + L+GL Y+ Sbjct: 77 TIQYRGCYLRE-----HTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYL 131 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 HS N++HRD+K N+L++ +K+ DFG A I P +V T ++ APE++L Sbjct: 132 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP-------ANSFVGTPYWMAPEVIL 184 Query: 218 --NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + Y +D+WS+G E+ +P + + L HI Sbjct: 185 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ---------------- 228 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 P+ W++ F + +D L P R T E L H ++ + Sbjct: 229 ------NESPALQSGHWSEYF-------RNFVDSCLQKIPQDRPTSEVLLKHRFVLRERP 275 Query: 336 PTD-EPVAEEPFTFAMELDDLPKERLKELIFQET 368 PT + + ELD+L ++K+++FQE Sbjct: 276 PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEA 309 >4JG6-A nrPDB Length = 355 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 84/318 (26%), Positives = 141/318 (44%), Gaps = 45/318 (14%) Query: 23 GVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYC 82 GV V+ + Y + IG G+Y + A+K I + Sbjct: 18 GVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE 77 Query: 83 QRTLREIQILLRF-RHENVIGIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLS 139 EI+ILLR+ +H N+I ++D+ + + VY+V +LM+ L K+L+ + S Sbjct: 78 -----EIEILLRYGQHPNIITLKDVY-----DDGKYVYVVTELMKGGELLDKILRQKFFS 127 Query: 140 NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL-INTTCD---LKICDFGLARIADPEH 195 L+ I + ++Y+H+ V+HRDLKPSN+L ++ + + ++ICDFG A+ E+ Sbjct: 128 EREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAEN 187 Query: 196 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLN 255 G L T + APE++ +GY + DIWS+G +L ML+ F D Sbjct: 188 ---GLLMTPCYTANFVAPEVL-ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPD-DTPE 242 Query: 256 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 315 IL +GS + A DL+ +ML +P Sbjct: 243 EILARIGSGKFS-----------------------LSGGYWNSVSDTAKDLVSKMLHVDP 279 Query: 316 NKRITVEEALAHPYLEQY 333 ++R+T L HP++ + Sbjct: 280 HQRLTAALVLRHPWIVHW 297 >2YZA-A nrPDB Length = 276 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 72/299 (24%), Positives = 118/299 (39%), Gaps = 44/299 (14%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHE 98 Y +G G +G V + +VA+K ++ + REIQ L FRH Sbjct: 12 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 71 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL-KSQQLSNDHICYFLYQILRGLKY 156 ++I + ++ T D ++V + + +L+ + K ++ QIL + Y Sbjct: 72 HIIKLYQVISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 126 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 H V+HRDLKP N+L++ + KI DFGL+ + FL + + Y APE++ Sbjct: 127 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE----FLRDSCGSPNYAAPEVI 182 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 +DIWS G IL +L F +H I Sbjct: 183 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI------------------- 223 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 R + +P + A LL ML +P KR T+++ H + +Q Sbjct: 224 -RGGVFYIPEYLNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQDLP 270 >2YAB-A nrPDB Length = 361 Score = 247 bits (631), Expect = 6e-66, Method: Composition-based stats. Identities = 78/337 (23%), Positives = 138/337 (40%), Gaps = 52/337 (15%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYC-----QRTLREIQI 91 V Y + +G G + +V + A K I + + + RE+ I Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSI 68 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL-KSQQLSNDHICYFLYQ 149 L + H N+I + D+ T DV ++ +L+ +L+ L + + LS + F+ Q Sbjct: 69 LRQVLHPNIITLHDVYENRT-----DVVLILELVSGGELFDFLAQKESLSEEEATSFIKQ 123 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTC----DLKICDFGLARIADPEHDHTGFLTEYV 205 IL G+ Y+H+ + H DLKP N+++ +K+ DFGLA + + Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE----FKNIF 179 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 T + APEI+ N + D+WS+G I +LS F G + L +I + Sbjct: 180 GTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFD 238 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 +E F ++ A D + ++L KR+T++EAL Sbjct: 239 EE---------------------------FFSQTSELAKDFIRKLLVKETRKRLTIQEAL 271 Query: 326 AHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKE 362 HP++ P D A + L++ K+ ++ Sbjct: 272 RHPWIT----PVDTQQAMVRRESVVNLENFKKQYVRR 304 >2J90-A nrPDB Length = 304 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 75/305 (24%), Positives = 128/305 (41%), Gaps = 48/305 (15%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYC-----QRTLREIQIL 92 V Y + +G G + +V A K I + + RE+ IL Sbjct: 24 VEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNIL 83 Query: 93 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL-KSQQLSNDHICYFLYQI 150 RH N+I + DI T DV ++ +L+ +L+ L + + L+ D FL QI Sbjct: 84 REIRHPNIITLHDIFENKT-----DVVLILELVSGGELFDFLAEKESLTEDEATQFLKQI 138 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTC----DLKICDFGLARIADPEHDHTGFLTEYVA 206 L G+ Y+HS + H DLKP N+++ +K+ DFG+A + ++ Sbjct: 139 LDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNE----FKNIFG 194 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 T + APEI+ N + D+WS+G I +LS F G+ + L +I + Sbjct: 195 TPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAV------ 247 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 NY + F + A D + R+L +P +R+T+ ++L Sbjct: 248 ------------NYDFD---------EEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLE 286 Query: 327 HPYLE 331 H +++ Sbjct: 287 HSWIK 291 >3GUB-A nrPDB Length = 295 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 78/306 (25%), Positives = 134/306 (43%), Gaps = 48/306 (15%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYC-----QRTLREIQI 91 +V Y + +G G + +V + + A K I ++ + RE+ I Sbjct: 8 NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSI 67 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL-KSQQLSNDHICYFLYQ 149 L +H NVI + ++ T DV ++ +L+ +L+ L + + L+ + FL Q Sbjct: 68 LKEIQHPNVITLHEVYENKT-----DVILIGELVAGGELFDFLAEKESLTEEEATEFLKQ 122 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTC----DLKICDFGLARIADPEHDHTGFLTEYV 205 IL G+ Y+HS + H DLKP N+++ +KI DFGLA D ++ Sbjct: 123 ILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNE----FKNIF 178 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 T + APEI+ N + D+WS+G I +LS F G + L Sbjct: 179 GTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLA---------- 227 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 N+ A NY + F + + A D + R+L +P KR+T++++L Sbjct: 228 --------NVSAVNYEFE---------DEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSL 270 Query: 326 AHPYLE 331 HP+++ Sbjct: 271 QHPWIK 276 >5DBX-A nrPDB Length = 328 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 73/303 (24%), Positives = 125/303 (41%), Gaps = 38/303 (12%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 Y + IG GA +V +A R+ RVAIK+I+ + QT L+EIQ + + H NV+ Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVV 72 Query: 102 GIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLK---------SQQLSNDHICYFLYQIL 151 ++ ++++V L+ + ++K + L I L ++L Sbjct: 73 TYY-----TSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVL 127 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD--HTGFLTEYVATRW 209 GL Y+H +HRDLK N+L+ ++I DFG++ D ++V T Sbjct: 128 EGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPC 187 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 269 + APE+M +GY D+WS G E+ + + + L +L + P + Sbjct: 188 WMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVL--MLTLQNDPPTLET 245 Query: 270 NCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY 329 + Y +S LL L +P+KR T E L + Sbjct: 246 GVEDKEMMKKYGKSF-------------------RKLLSLCLQKDPSKRPTAAELLKCKF 286 Query: 330 LEQ 332 ++ Sbjct: 287 FQK 289 >4LG4-A nrPDB Length = 299 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 79/310 (25%), Positives = 132/310 (42%), Gaps = 47/310 (15%) Query: 26 GEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT 85 GE + K QP +V + L+ +GEG+YG V A VAIK++ ++ Q Sbjct: 1 GEDSLTK-QPEEV---FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV---PVESDLQEI 53 Query: 86 LREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKL--LKSQQLSNDH 142 ++EI I+ + V+ +T D++IV + + + L+++ L D Sbjct: 54 IKEISIMQQCDSPYVVKYYGSYFKNT-----DLWIVMEYCGAGSVSDIIRLRNKTLIEDE 108 Query: 143 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLT 202 I L L+GL+Y+H +HR++K N+L+NT K+ DFG+A D Sbjct: 109 IATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLT---DTMAKRN 165 Query: 203 EYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILG 262 + T ++ APE++ GY DIWS+G EM +P + H + I I Sbjct: 166 TVIGTPFWMAPEVI-QEIGYNCVADIWSLGITSIEMAEGKPPYADIH---PMRAIFMIPT 221 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVE 322 +P + W+ F D + + L NP +R T Sbjct: 222 NPPPTF------------------RKPELWSDDF-------TDFVKKCLVKNPEQRATAT 256 Query: 323 EALAHPYLEQ 332 + L HP+++ Sbjct: 257 QLLQHPFIKN 266 >2F57-A nrPDB Length = 317 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 73/292 (25%), Positives = 130/292 (44%), Gaps = 39/292 (13%) Query: 47 YIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDI 106 IGEG+ G+V A + +VA+KK+ Q + E+ I+ + H+NV+ + Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMD-LRKQQRRELLFNEVVIMRDYHHDNVVDMY-- 108 Query: 107 LRASTLEAMRDVYIVQDLMETD-LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHR 165 S+ ++++V + +E L ++ +++ + I +LR L Y+H+ V+HR Sbjct: 109 ---SSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHR 165 Query: 166 DLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 225 D+K ++L+ + +K+ DFG E V T ++ APE++ + Y Sbjct: 166 DIKSDSILLTSDGRIKLSDFGFCAQVSKE---VPKRKSLVGTPYWMAPEVI-SRLPYGTE 221 Query: 226 IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLP 285 +DIWS+G ++ EM+ P + + L + I SLP Sbjct: 222 VDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRD-----------------------SLP 258 Query: 286 SKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 + K K S LD ML P++R T +E L HP+L+ P+ Sbjct: 259 PRVKD-----LHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPS 305 >2HW6-A nrPDB Length = 307 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 125/300 (41%), Gaps = 32/300 (10%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR-HENVIGIR 104 + +GEGAY V A A+K I + R RE++ L + + ++N++ + Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHS-RSRVFREVETLYQCQGNKNILELI 77 Query: 105 DILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANV 162 + T Y+V + ++ L + K + + + + L ++H+ + Sbjct: 78 EFFEDDTR-----FYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGI 132 Query: 163 LHRDLKPSNLLINTT---CDLKICDFGLARIADPEHDHTGF----LTEYVATRWYRAPEI 215 HRDLKP N+L + +KICDF L + T LT + Y APE+ Sbjct: 133 AHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEV 192 Query: 216 ML----NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 + + Y K D+WS+G +L MLS P F G G+ D Sbjct: 193 VEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGH------------CGADCGWDRGE 240 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + + +S+ K + S+A DL+ ++L + +R++ + L HP+++ Sbjct: 241 VCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 >2W4O-A nrPDB Length = 349 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 79/329 (24%), Positives = 131/329 (39%), Gaps = 50/329 (15%) Query: 14 PRRTEGVGPGVPGEVEMVKGQPFDVGPR------YTQLQYIGEGAYGMVSSAYDHVRKTR 67 + PG +V D R + +G GA +V + Sbjct: 21 QSMSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKP 80 Query: 68 VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-E 126 A+K + + + EI +LLR H N+I +++I T ++ +V +L+ Sbjct: 81 YALKVLKKTVDKKIVR---TEIGVLLRLSHPNIIKLKEIFETPT-----EISLVLELVTG 132 Query: 127 TDLYK-LLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT---TCDLKI 182 +L+ +++ S + QIL + Y+H ++HRDLKP NLL T LKI Sbjct: 133 GELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKI 192 Query: 183 CDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 242 DFGL++I +H + T Y APEI+ Y +D+WSVG I +L Sbjct: 193 ADFGLSKIV----EHQVLMKTVCGTPGYCAPEILRGC-AYGPEVDMWSVGIITYILLCGF 247 Query: 243 PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSK 302 F + + D + Y P +V+ Sbjct: 248 EPFYDE-----------------RGDQFMFRRILNCEYYFISPWWDEVSLN--------- 281 Query: 303 ALDLLDRMLTFNPNKRITVEEALAHPYLE 331 A DL+ +++ +P KR+T +AL HP++ Sbjct: 282 AKDLVRKLIVLDPKKRLTTFQALQHPWVT 310 >6AO5-A nrPDB Length = 362 Score = 244 bits (622), Expect = 6e-65, Method: Composition-based stats. Identities = 76/307 (24%), Positives = 130/307 (42%), Gaps = 46/307 (14%) Query: 29 EMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLRE 88 + + QP +V + L+ +GEG+YG V A VAIK++ ++ Q ++E Sbjct: 2 DSLTKQPEEV---FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV---PVESDLQEIIKE 55 Query: 89 IQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKL--LKSQQLSNDHICY 145 I I+ + V+ +T D++IV + + + L+++ L D I Sbjct: 56 ISIMQQCDSPYVVKYYGSYFKNT-----DLWIVMEYCGAGSVSDIIRLRNKTLIEDEIAT 110 Query: 146 FLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYV 205 L L+GL+Y+H +HR++K N+L+NT K+ DFG+A D + Sbjct: 111 ILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLT---DTMAKRNTVI 167 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 T ++ APE++ GY DIWS+G EM +P + H + I I +P Sbjct: 168 GTPFWMAPEVI-QEIGYNCVADIWSLGITSIEMAEGKPPYADIH---PMRAIFMIPTNPP 223 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 + W+ F D + + L NP +R T + L Sbjct: 224 PTF------------------RKPELWSDDF-------TDFVKKCLVKNPEQRATATQLL 258 Query: 326 AHPYLEQ 332 HP+++ Sbjct: 259 QHPFIKN 265 >3ZUT-A nrPDB Length = 362 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 77/347 (22%), Positives = 133/347 (38%), Gaps = 45/347 (12%) Query: 22 PGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY 81 P V G +++ RY ++ IG G +G+ D VA+K I E Sbjct: 4 PAVSGPMDL---PIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID- 59 Query: 82 CQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYK-LLKSQQLS 139 + REI RH N++ ++++ T A IV + +L++ + + + S Sbjct: 60 -ENVKREIINHRSLRHPNIVRFKEVILTPTHLA-----IVMEYASGGELFERICNAGRFS 113 Query: 140 NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC--DLKICDFGLARIADPEHDH 197 D +F Q++ G+ Y H+ V HRDLK N L++ + LKIC FG ++ + Sbjct: 114 EDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLH--- 170 Query: 198 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 257 V T Y APE++L + K D+WS G L ML F Sbjct: 171 -SQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKT 229 Query: 258 LGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNK 317 + + N ++P + L+ R+ +P K Sbjct: 230 I----------------HRILNVQYAIPDYV---------HISPECRHLISRIFVADPAK 264 Query: 318 RITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELI 364 RI++ E H + + + T + D P + ++E++ Sbjct: 265 RISIPEIRNHEWFLKNLPADLMN--DNTMTTQFDESDQPGQSIEEIM 309 >3IS5-A nrPDB Length = 285 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 76/305 (24%), Positives = 127/305 (41%), Gaps = 48/305 (15%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 + + + +G GA+G V + IK I+ Q ++ EI++L Sbjct: 19 TIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLD 78 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLL-----KSQQLSNDHICYFLYQI 150 H N+I I ++ E ++YIV + E +L + + + + LS ++ + Q+ Sbjct: 79 HPNIIKIFEVF-----EDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQM 133 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 + L Y HS +V+H+DLKP N+L +KI DFGLA + + T T Sbjct: 134 MNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDE----HSTNAAGT 189 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 Y APE+ + T DIWS G ++ +L+ F G S E Sbjct: 190 ALYMAPEVF--KRDVTFKCDIWSAGVVMYFLLTGCLPFTGT----------------SLE 231 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAH 327 ++ K NY +A+DLL +MLT +P +R + + L H Sbjct: 232 EVQQKATYKEPNYAVECRP------------LTPQAVDLLKQMLTKDPERRPSAAQVLHH 279 Query: 328 PYLEQ 332 + +Q Sbjct: 280 EWFKQ 284 >4L42-A nrPDB Length = 346 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 73/346 (21%), Positives = 139/346 (40%), Gaps = 54/346 (15%) Query: 23 GVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHV---RKTRVAIKKISP---F 76 G E + +G + L+ +G+G YG V A+K + Sbjct: 1 GAMSETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIV 60 Query: 77 EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKS 135 + T E IL +H ++ + + +Y++ + + +L+ L+ Sbjct: 61 RNAKDTAHTKAERNILEEVKHPFIVDLI-----YAFQTGGKLYLILEYLSGGELFMQLER 115 Query: 136 QQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPE 194 + D C++L +I L ++H +++RDLKP N+++N +K+ DFGL + + + Sbjct: 116 EGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHD 175 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 T + T Y APEI++ S G+ +++D WS+G ++ +ML+ P F G++ + Sbjct: 176 GTVTH---TFCGTIEYMAPEILMRS-GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTI 231 Query: 255 NHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFN 314 + IL L P +A DLL ++L N Sbjct: 232 DKILKCK-------------------------------LNLPPYLTQEARDLLKKLLKRN 260 Query: 315 PNKRI-----TVEEALAHPYLEQ-YYDPTDEPVAEEPFTFAMELDD 354 R+ E AHP+ ++ E PF ++ ++ Sbjct: 261 AASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEE 306 >4CRL-A nrPDB Length = 406 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 115/352 (32%), Positives = 168/352 (47%), Gaps = 46/352 (13%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTR--VAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 Y + G G YG V A K A+K+I E REI +L +H N Sbjct: 25 YEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQI---EGTGISMSACREIALLRELKHPN 80 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ----------LSNDHICYFLYQ 149 VI ++ + + A R V+++ D E DL+ ++K + L + LYQ Sbjct: 81 VISLQKVFLS---HADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQ 137 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLIN----TTCDLKICDFGLARIADPEHDHTGFLTEYV 205 IL G+ Y+H+ VLHRDLKP+N+L+ +KI D G AR+ + L V Sbjct: 138 ILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVV 197 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKH---------YLDQLNH 256 T WYRAPE++L ++ YTK+IDIW++GCI AE+L++ PIF + + DQL+ Sbjct: 198 VTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDR 257 Query: 257 ILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFP-------KSDSKALDLLDR 309 I ++G P+ +D I M + L + L K DSKA LL + Sbjct: 258 IFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQK 317 Query: 310 MLTFNPNKRITVEEALAHPYLEQYYDPTDE-------PVAEEPFTFAMELDD 354 +LT +P KRIT E+A+ PY + PT + P + F E DD Sbjct: 318 LLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDD 369 >6CMJ-A nrPDB Length = 321 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 78/334 (23%), Positives = 144/334 (43%), Gaps = 51/334 (15%) Query: 27 EVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYC---- 82 V + Q +YT IG+G+YG+V AY+ T A+K +S + Sbjct: 21 HVSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCI 80 Query: 83 ------QRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKS 135 ++ +EI IL + H NV+ + ++L + +Y+V +L+ + ++ Sbjct: 81 QPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNED---HLYMVFELVNQGPVMEVPTL 137 Query: 136 QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH 195 + LS D ++ +++G++Y+H ++HRD+KPSNLL+ +KI DFG++ Sbjct: 138 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSD 197 Query: 196 DHTGFLTEYVATRWYRAPEIMLNSKG--YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQ 253 L+ V T + APE + ++ K++D+W++G L + + F Sbjct: 198 ---ALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-------- 246 Query: 254 LNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTF 313 ++ ++ K ++ P + P DL+ RML Sbjct: 247 ------------MDERIMCLHSKIKSQALEFPDQ---------PDIAEDLKDLITRMLDK 285 Query: 314 NPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFT 347 NP RI V E HP++ ++ EP+ E Sbjct: 286 NPESRIVVPEIKLHPWVTRHGA---EPLPSEDEN 316 >4FIE-A nrPDB Length = 423 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 74/327 (22%), Positives = 135/327 (41%), Gaps = 42/327 (12%) Query: 13 EPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKK 72 EP+R ++ + G P + IGEG+ G+V A VA+KK Sbjct: 127 EPQRVSHEQFRAALQLVVDPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLVAVKK 183 Query: 73 ISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYK 131 + Q + E+ I+ ++HENV+ + + + ++++V + +E L Sbjct: 184 MD-LRKQQRRELLFNEVVIMRDYQHENVVEMYN-----SYLVGDELWVVMEFLEGGALTD 237 Query: 132 LLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA 191 ++ +++ + I +L+ L +H+ V+HRD+K ++L+ +K+ DFG Sbjct: 238 IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV 297 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 251 E V T ++ APE +++ Y +DIWS+G ++ EM+ P + + L Sbjct: 298 SKE---VPRRKSLVGTPYWMAPE-LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPL 353 Query: 252 DQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRML 311 + I +LP + K K LDR+L Sbjct: 354 KAMKMIRD-----------------------NLPPRLKN-----LHKVSPSLKGFLDRLL 385 Query: 312 TFNPNKRITVEEALAHPYLEQYYDPTD 338 +P +R T E L HP+L + P Sbjct: 386 VRDPAQRATAAELLKHPFLAKAGPPAS 412 >4JXF-A nrPDB Length = 266 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 74/296 (25%), Positives = 128/296 (43%), Gaps = 45/296 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFRHEN 99 + +G+G++ V A VAIK I QR E++I + +H + Sbjct: 9 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS 68 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQ--QLSNDHICYFLYQILRGLKY 156 ++ + + S VY+V ++ ++ + LK++ S + +F++QI+ G+ Y Sbjct: 69 ILELYNYFEDS-----NYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLY 123 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 +HS +LHRDL SNLL+ ++KI DFGLA H+ L T Y +PEI Sbjct: 124 LHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTL---CGTPNYISPEIA 180 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + D+WS+GC+ +L RP F + LN ++ Sbjct: 181 -TRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLA---------------- 223 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 +PS +A DL+ ++L NP R+++ L HP++ + Sbjct: 224 ----DYEMPSF-----------LSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSR 264 >5JZN-A nrPDB Length = 280 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 76/304 (25%), Positives = 130/304 (42%), Gaps = 43/304 (14%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 P + RY + IG+G + +V + A+K I + + E+ IL R Sbjct: 14 PATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRR 73 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKS-QQLSNDHICYFLYQILR 152 +H N++ + + ++ ++Y+V +L+ DL+ + S + + LY + Sbjct: 74 VKHPNIVLLIE-----EMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLAS 128 Query: 153 GLKYIHSANVLHRDLKPSNLLI----NTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 +KY+HS N++HRD+KP NLL+ + + LK+ DFGLA I D G L T Sbjct: 129 AIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVD------GPLYTVCGTP 182 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 Y APEI+ + GY +DIW+ G I +L P F G D Sbjct: 183 TYVAPEIIAET-GYGLKVDIWAAGVITYILLCGFPPFRGSG------------------D 223 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 328 ++ + PS + A +L+ ML + ++R + + L HP Sbjct: 224 DQEVLFDQILMGQVDFPSP-------YWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHP 276 Query: 329 YLEQ 332 ++ Sbjct: 277 WVND 280 >4XBR-A nrPDB Length = 366 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 74/327 (22%), Positives = 135/327 (41%), Gaps = 42/327 (12%) Query: 13 EPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKK 72 EP+R ++ + G P + IGEG+ G+V A VA+KK Sbjct: 70 EPQRVSHEQFRAALQLVVDPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLVAVKK 126 Query: 73 ISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYK 131 + Q + E+ I+ ++HENV+ + + + ++++V + +E L Sbjct: 127 MD-LRKQQRRELLFNEVVIMRDYQHENVVEMYN-----SYLVGDELWVVMEFLEGGALTD 180 Query: 132 LLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA 191 ++ +++ + I +L+ L +H+ V+HRD+K ++L+ +K+ DFG Sbjct: 181 IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV 240 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 251 E V T ++ APE +++ Y +DIWS+G ++ EM+ P + + L Sbjct: 241 SKE---VPRRKSLVGTPYWMAPE-LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPL 296 Query: 252 DQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRML 311 + I +LP + K K LDR+L Sbjct: 297 KAMKMIRD-----------------------NLPPRLKN-----LHKVSPSLKGFLDRLL 328 Query: 312 TFNPNKRITVEEALAHPYLEQYYDPTD 338 +P +R T E L HP+L + P Sbjct: 329 VRDPAQRATAAELLKHPFLAKAGPPAS 355 >2Q0N-A nrPDB Length = 301 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 74/327 (22%), Positives = 135/327 (41%), Gaps = 42/327 (12%) Query: 13 EPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKK 72 EP+R ++ + G P + IGEG+ G+V A VA+KK Sbjct: 5 EPQRVSHEQFRAALQLVVDPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLVAVKK 61 Query: 73 ISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYK 131 + Q + E+ I+ ++HENV+ + + + ++++V + +E L Sbjct: 62 MD-LRKQQRRELLFNEVVIMRDYQHENVVEMYN-----SYLVGDELWVVMEFLEGGALTD 115 Query: 132 LLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA 191 ++ +++ + I +L+ L +H+ V+HRD+K ++L+ +K+ DFG Sbjct: 116 IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV 175 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 251 E V T ++ APE +++ Y +DIWS+G ++ EM+ P + + L Sbjct: 176 SKE---VPRRKSLVGTPYWMAPE-LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPL 231 Query: 252 DQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRML 311 + I +LP + K K LDR+L Sbjct: 232 KAMKMIRD-----------------------NLPPRLKN-----LHKVSPSLKGFLDRLL 263 Query: 312 TFNPNKRITVEEALAHPYLEQYYDPTD 338 +P +R T E L HP+L + P Sbjct: 264 VRDPAQRATAAELLKHPFLAKAGPPAS 290 >2A27-A nrPDB Length = 321 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 79/337 (23%), Positives = 138/337 (40%), Gaps = 52/337 (15%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYC-----QRTLREIQI 91 V Y + +G G + +V + A K I + + + RE+ I Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSI 68 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL-KSQQLSNDHICYFLYQ 149 L + H NVI + D+ T DV ++ +L+ +L+ L + + LS + F+ Q Sbjct: 69 LRQVLHHNVITLHDVYENRT-----DVVLILELVSGGELFDFLAQKESLSEEEATSFIKQ 123 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTC----DLKICDFGLARIADPEHDHTGFLTEYV 205 IL G+ Y+H+ + H DLKP N+++ +K+ DFGLA + + Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE----FKNIF 179 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 T + APEI+ N + D+WS+G I +LS F G + L +I + Sbjct: 180 GTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFD 238 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 +E F ++ A D + ++L KR+T++EAL Sbjct: 239 EE---------------------------FFSQTSELAKDFIRKLLVKETRKRLTIQEAL 271 Query: 326 AHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKE 362 HP++ P D A + L++ K+ ++ Sbjct: 272 RHPWIT----PVDNQQAMVRRESVVNLENFRKQYVRR 304 >4I6B-A nrPDB Length = 308 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 76/304 (25%), Positives = 131/304 (43%), Gaps = 44/304 (14%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILLRFR 96 G RY++ + +G+G + D A K I S ++ +EI++ Sbjct: 27 GKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILH 86 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRGL 154 H++V+ E ++YI+ + + +LK+++ L+ + Y+L QI+ GL Sbjct: 87 HKHVVQFYHYF-----EDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGL 141 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 KY+H +LHRDLK N IN + +LK+ DFGLA +P T Y +PE Sbjct: 142 KYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHR---RRTICGTPNYLSPE 198 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 ++ N +G+ DIW++GC++ ML RP F + + I Sbjct: 199 VL-NKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSI----------------- 240 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 334 R ++PS A L+ ML+ NP R ++++ + H + Q + Sbjct: 241 ---REARYTMPSSLLAP-----------AKHLIASMLSKNPEDRPSLDDIIRHDFFTQGF 286 Query: 335 DPTD 338 P Sbjct: 287 TPDR 290 >4PDS-A nrPDB Length = 347 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 79/335 (23%), Positives = 131/335 (39%), Gaps = 58/335 (17%) Query: 13 EPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKK 72 P T MV + + +G+GA+ V A + ++K Sbjct: 10 SPGLTSSTAS------SMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKI 63 Query: 73 ISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYK 131 IS + RE+++L + H ++ ++ E Y+V + + DL Sbjct: 64 ISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY-----EDTESYYMVMEFVSGGDLMD 118 Query: 132 LLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD--LKICDFGLA 188 + + + D QIL +KYIHS + HRDLKP N+LI +KI FGLA Sbjct: 119 FVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLA 178 Query: 189 RIADPEHDHTGFLTEYVATRWYRAPEIMLNSKG------------YTKSIDIWSVGCILA 236 ++ + F+ + T Y APE++ Y+ +D+WS+GC++ Sbjct: 179 KV----QGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVY 234 Query: 237 EMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLF 296 +L+ F G DQL +G R P K Sbjct: 235 VILTGHLPFSG-STQDQLYKQIG------------------RGSYHEGPLKDF------- 268 Query: 297 PKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + +A D +D +L +PN R T +AL HP+++ Sbjct: 269 -RISEEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >2X4F-A nrPDB Length = 373 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 79/320 (24%), Positives = 132/320 (41%), Gaps = 45/320 (14%) Query: 21 GPGVPGEVEMVKGQPFDVGPRYTQLQY--IGEGAYGMVSSAYDHVRKTRVAIKKISPFEH 78 P P + +V + V YT + +G G +G V + ++A K I Sbjct: 68 APPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIK-TRG 126 Query: 79 QTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLL--KS 135 + EI ++ + H N+I + D E+ D+ +V + ++ +L+ + +S Sbjct: 127 MKDKEEVKNEISVMNQLDHANLIQLYDAF-----ESKNDIVLVMEYVDGGELFDRIIDES 181 Query: 136 QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT--CDLKICDFGLARIADP 193 L+ F+ QI G++++H +LH DLKP N+L +KI DFGLAR P Sbjct: 182 YNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKP 241 Query: 194 EHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQ 253 L T + APE++ N + D+WSVG I +LS F G + + Sbjct: 242 REK----LKVNFGTPEFLAPEVV-NYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAET 296 Query: 254 LNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTF 313 LN+IL E+ F +A + + ++L Sbjct: 297 LNNILACRWDLEDEE---------------------------FQDISEEAKEFISKLLIK 329 Query: 314 NPNKRITVEEALAHPYLEQY 333 + RI+ EAL HP+L + Sbjct: 330 EKSWRISASEALKHPWLSDH 349 >3Q53-A nrPDB Length = 306 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 131/296 (44%), Gaps = 39/296 (13%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 D +YT+ + IG+GA G V +A D VAI++++ + Q + + EI ++ + Sbjct: 18 DPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN-LQQQPKKELIINEILVMRENK 76 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQLSNDHICYFLYQILRGLK 155 + N++ D + ++++V + + L ++ + I + L+ L+ Sbjct: 77 NPNIVNYLD-----SYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALE 131 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 ++HS V+HRD+K N+L+ +K+ DFG PE + V T ++ APE+ Sbjct: 132 FLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ---SKRSTMVGTPYWMAPEV 188 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + K Y +DIWS+G + EM+ P + ++ L L I G+P ++ Sbjct: 189 V-TRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI-ATNGTPELQNPE----- 241 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 K + D L+R L + KR + +E + H +L+ Sbjct: 242 ----------------------KLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >4JDH-A nrPDB Length = 346 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 74/327 (22%), Positives = 135/327 (41%), Gaps = 42/327 (12%) Query: 13 EPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKK 72 EP+R ++ + G P + IGEG+ G+V A VA+KK Sbjct: 50 EPQRVSHEQFRAALQLVVDPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLVAVKK 106 Query: 73 ISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYK 131 + Q + E+ I+ ++HENV+ + + + ++++V + +E L Sbjct: 107 MD-LRKQQRRELLFNEVVIMRDYQHENVVEMYN-----SYLVGDELWVVMEFLEGGALTD 160 Query: 132 LLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA 191 ++ +++ + I +L+ L +H+ V+HRD+K ++L+ +K+ DFG Sbjct: 161 IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV 220 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 251 E V T ++ APE +++ Y +DIWS+G ++ EM+ P + + L Sbjct: 221 SKE---VPRRKSLVGTPYWMAPE-LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPL 276 Query: 252 DQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRML 311 + I +LP + K K LDR+L Sbjct: 277 KAMKMIRD-----------------------NLPPRLKN-----LHKVSPSLKGFLDRLL 308 Query: 312 TFNPNKRITVEEALAHPYLEQYYDPTD 338 +P +R T E L HP+L + P Sbjct: 309 VRDPAQRATAAELLKHPFLAKAGPPAS 335 >4KS7-A nrPDB Length = 292 Score = 241 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 68/307 (22%), Positives = 128/307 (41%), Gaps = 42/307 (13%) Query: 32 KGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQI 91 +G P + Y IGEG+ G+V A + +VA+K + Q + E+ I Sbjct: 18 QGDPRLLLDSYV---KIGEGSTGIVCLAREKHSGRQVAVKMMD-LRKQQRRELLFNEVVI 73 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLKSQQLSNDHICYFLYQI 150 + ++H NV+ + + +++++ + ++ L ++ +L+ + I + Sbjct: 74 MRDYQHFNVVEMY-----KSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAV 128 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY 210 L+ L Y+H+ V+HRD+K ++L+ +K+ DFG + V T ++ Sbjct: 129 LQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKD---VPKRKSLVGTPYW 185 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 APE++ S Y +DIWS+G ++ EM+ P + + + + Sbjct: 186 MAPEVISRS-LYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRL------------- 231 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + K K D L+RML +P +R T +E L HP+L Sbjct: 232 ---------------RDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL 276 Query: 331 EQYYDPT 337 Q P Sbjct: 277 LQTGLPE 283 >6O6Q-A nrPDB Length = 335 Score = 241 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 84/304 (27%), Positives = 153/304 (50%), Gaps = 20/304 (6%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95 ++ Y L+ +G G Y V D ++ +V IK + P + ++ REI IL Sbjct: 37 WNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVK----RKKIKREISILKNL 92 Query: 96 -RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGL 154 N+I + D++R ++ I + + D L ++ I +++Y++L+ L Sbjct: 93 VDGPNIIAMLDVVREP--QSKTPGLIFEHINNIDFRSLY--PTFTDYDIRFYMYELLKAL 148 Query: 155 KYIHSANVLHRDLKPSNLLINTTCD-LKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 Y HS ++HRD+KP N++I+ L++ D+GLA P ++ VA+R+++ P Sbjct: 149 DYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNV----RVASRYFKGP 204 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEM-LSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 E++++ + Y S+D+WS GC+LA M P F GK DQL I+ +LGS + + Sbjct: 205 ELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEK 264 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPK-----SDSKALDLLDRMLTFNPNKRITVEEALAH 327 N+ + + K W + + + LDL+DR+L ++ +R+T +EA+ H Sbjct: 265 YNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKH 324 Query: 328 PYLE 331 Y + Sbjct: 325 AYFD 328 >3UC3-A nrPDB Length = 361 Score = 241 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 72/321 (22%), Positives = 120/321 (37%), Gaps = 40/321 (12%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 RY ++ IG G +G+ D + K VA+K I + REI RH N Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID--ENVQREIINHRSLRHPN 77 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLM-ETDLYK-LLKSQQLSNDHICYFLYQILRGLKYI 157 ++ ++++ T A I+ + +LY+ + + + S D +F Q+L G+ Y Sbjct: 78 IVRFKEVILTPTHLA-----IIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 Query: 158 HSANVLHRDLKPSNLLINTT--CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 HS + HRDLK N L++ + LKICDFG ++ + V T Y APE+ Sbjct: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLH----SQPKSTVGTPAYIAPEV 188 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 +L + K D+WS G L ML F + + S + I Sbjct: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--- 245 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 + + L+ R+ +P RI++ E H + + Sbjct: 246 ----------------------RISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLP 283 Query: 336 PTDEPVAEEPFTFAMELDDLP 356 + F + Sbjct: 284 ADLMNESNTGSQFQEPEQPMQ 304 >3UDB-A nrPDB Length = 317 Score = 241 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 74/329 (22%), Positives = 127/329 (38%), Gaps = 42/329 (12%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 RY ++ IG G +G+ D VA+K I E + REI RH N Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKID--ENVKREIINHRSLRHPN 76 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLM-ETDLYK-LLKSQQLSNDHICYFLYQILRGLKYI 157 ++ ++++ T A IV + +L++ + + + S D +F Q++ G+ Y Sbjct: 77 IVRFKEVILTPTHLA-----IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYA 131 Query: 158 HSANVLHRDLKPSNLLINTTC--DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 H+ V HRDLK N L++ + LKI DFG ++ + V T Y APE+ Sbjct: 132 HAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLH----SQPKSAVGTPAYIAPEV 187 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 +L + K D+WS G L ML F + Sbjct: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI----------------H 231 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 + N ++P + L+ R+ +P KRI++ E H + + Sbjct: 232 RILNVQYAIPDYV---------HISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLP 282 Query: 336 PTDEPVAEEPFTFAMELDDLPKERLKELI 364 + T + D P + ++E++ Sbjct: 283 ADLMN--DNTMTTQFDESDQPGQSIEEIM 309 >6CKI-A nrPDB Length = 316 Score = 241 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 74/316 (23%), Positives = 123/316 (38%), Gaps = 33/316 (10%) Query: 42 YTQLQ-YIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR-HEN 99 Y + +GEGA+ V + + + A+K I R RE+++L + + H N Sbjct: 14 YQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHI-RSRVFREVEMLYQCQGHRN 72 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGLKYI 157 V + E Y+V + M L + K + + + + L ++ Sbjct: 73 V-----LELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFL 127 Query: 158 HSANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLT----EYVATRWY 210 H+ + HRDLKP N+L +KICDFGL D + T + Y Sbjct: 128 HNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEY 187 Query: 211 RAPEIM----LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 APE++ + Y K D+WS+G IL +LS P F G+ D G Sbjct: 188 MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD--------CGWDRG 239 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 E NM + + WA + A DL+ ++L + +R++ + L Sbjct: 240 EACPACQNMLFESIQEGKYEFPDKDWAHI----SCAAKDLISKLLVRDAKQRLSAAQVLQ 295 Query: 327 HPYLEQYYDPTDEPVA 342 HP+++ P Sbjct: 296 HPWVQGCAPENTLPTP 311 >4YNZ-A nrPDB Length = 342 Score = 240 bits (613), Expect = 6e-64, Method: Composition-based stats. Identities = 76/318 (23%), Positives = 132/318 (41%), Gaps = 46/318 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENV 100 Y + +G+G G+V V +VAIK ++ + ++ + REI IL H +V Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 101 IGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL-KSQQLSNDHICYFLYQILRGLKYIH 158 + + D+ E + +Y+V + + +L+ L K +L+ F QI+ L + H Sbjct: 72 LKLHDVY-----ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 126 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 S ++ HRDLKP NLL++ +++I DFG+A + + L + Y PE++ Sbjct: 127 SHSICHRDLKPENLLLDERNNIRIADFGMASLQVGD----SLLETSCGSPHYACPEVIRG 182 Query: 219 SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKAR 278 K + D+WS G IL +L F + Sbjct: 183 EKYDGRKADVWSCGVILFALLVGALPFDDDN----------------------------- 213 Query: 279 NYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTD 338 L+ L K K + LL M+ + +R+T+E H + Y + Sbjct: 214 --LRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIW---YIGGKN 268 Query: 339 EPVAEEPFTFAMELDDLP 356 EP E+P +++ LP Sbjct: 269 EPEPEQPIPRKVQIRSLP 286 >3TAC-A nrPDB Length = 361 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 127/304 (41%), Gaps = 50/304 (16%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY----CQRTLREIQILLRFRH 97 Y + IG+G + +V + + A+K + + + + RE I +H Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMET-DL-YKLLKSQQ----LSNDHICYFLYQIL 151 +++ + + T + +Y+V + M+ DL ++++K S +++ QIL Sbjct: 88 PHIVELLE-----TYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQIL 142 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCD---LKICDFGLARIADPEHDHTGFLTEYVATR 208 L+Y H N++HRD+KP +L+ + + +K+ FG+A + V T Sbjct: 143 EALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQL---GESGLVAGGRVGTP 199 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 + APE++ + Y K +D+W G IL +LS F G Sbjct: 200 HFMAPEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYG--------------------- 237 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 328 + + + + A DL+ RML +P +RITV EAL HP Sbjct: 238 -------TKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHP 290 Query: 329 YLEQ 332 +L++ Sbjct: 291 WLKE 294 >3D2K-A nrPDB Length = 272 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 69/294 (23%), Positives = 123/294 (41%), Gaps = 46/294 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF--EHQTYCQRTLREIQILLRFRHEN 99 + + +G+G +G V A + K +A+K + E + RE++I RH N Sbjct: 14 FDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPN 73 Query: 100 VIGIRDILRASTLEAMRDVYIVQDL--METDLYKLLKSQQLSNDHICYFLYQILRGLKYI 157 ++ + +T VY++ + + T +L K + ++ ++ L Y Sbjct: 74 ILRLYGYFHDATR-----VYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYC 128 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 HS V+HRD+KP NLL+ + +LKI DFG + H + T T Y PE++ Sbjct: 129 HSKRVIHRDIKPENLLLGSNGELKIADFGWSV-----HAPSSRRTTLCGTLDYLPPEMIE 183 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 + + + +D+WS+G + E L P F Y + I + Sbjct: 184 G-RMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRV----------------- 225 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + P A DL+ R+L N ++R+T+ E L HP+++ Sbjct: 226 ---EFTFPDF-----------VTEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >6C9D-A nrPDB Length = 459 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 65/321 (20%), Positives = 127/321 (39%), Gaps = 46/321 (14%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHEN 99 Y + IG+G + V A + VA+K I + + T Q+ RE++I+ H N Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 81 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQ-QLSNDHICYFLYQILRGLKYI 157 ++ + +++ E + +Y+V + +++ L + ++ QI+ ++Y Sbjct: 82 IVKLFEVI-----ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 136 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 H ++HRDLK NLL++ ++KI DFG + E L E+ + Y APE+ Sbjct: 137 HQKYIVHRDLKAENLLLDGDMNIKIADFGFS----NEFTVGNKLDEFCGSPPYAAPELFQ 192 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 K +D+WS+G IL ++S F G++ + +L Sbjct: 193 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR------------------ 234 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 +P L K P KR ++E+ + ++ ++ Sbjct: 235 --GKYRIPFYMSTDCENLLKKLLVLN-----------PIKRGSLEQIMKDRWMNVGHEEE 281 Query: 338 DEP---VAEEPFTFAMELDDL 355 + + F +D + Sbjct: 282 ELKPYTEPDPDFNDTKRIDIM 302 >1ZWS-A nrPDB Length = 288 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 74/306 (24%), Positives = 126/306 (41%), Gaps = 48/306 (15%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYC-----QRTLREIQI 91 V Y + +G G + +V + A K I + + + RE+ I Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSI 68 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL-KSQQLSNDHICYFLYQ 149 L + H NVI + D+ T DV ++ +L+ +L+ L + + LS + F+ Q Sbjct: 69 LRQVLHHNVITLHDVYENRT-----DVVLILELVSGGELFDFLAQKESLSEEEATSFIKQ 123 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTC----DLKICDFGLARIADPEHDHTGFLTEYV 205 IL G+ Y+H+ + H DLKP N+++ +K+ DFGLA + + Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE----FKNIF 179 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 T + APEI+ N + D+WS+G I +LS F G + L +I + Sbjct: 180 GTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFD 238 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 +E F + A D + ++L KR+T++EAL Sbjct: 239 EE---------------------------FFSHTSELAKDFIRKLLVKETRKRLTIQEAL 271 Query: 326 AHPYLE 331 HP++ Sbjct: 272 RHPWIT 277 >6FDY-U nrPDB Length = 276 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 73/302 (24%), Positives = 134/302 (44%), Gaps = 44/302 (14%) Query: 42 YTQLQYIGEGAYGMVSSAY-DHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFRHEN 99 + + +G G Y V AY + VAIK + ++ + L EI+IL RH + Sbjct: 13 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPH 72 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ-LSNDHICYFLYQILRGLKYI 157 ++ ++D ++Y++ + DL + + +++ L F+ Q+ L+++ Sbjct: 73 IVQLKDF-----QWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFL 127 Query: 158 HSANVLHRDLKPSNLLIN--TTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 H N+ H DLKP N+L++ LK+ DFG A+ P + + Y APE+ Sbjct: 128 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLR----GSPLYMAPEM 183 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + + Y +D+WS+G IL E L +P F + + + I Sbjct: 184 VCQRQ-YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRS---------------- 226 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 N + LP + P DLL R+L +P++RI+ ++ AHP+++ + Sbjct: 227 ---NRVIELPLR---------PLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHM 274 Query: 336 PT 337 P+ Sbjct: 275 PS 276 >4UZD-A nrPDB Length = 287 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 69/294 (23%), Positives = 122/294 (41%), Gaps = 46/294 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP--FEHQTYCQRTLREIQILLRFRHEN 99 + + +G+G +G V A + K +A+K + E + RE++I RH N Sbjct: 10 FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPN 69 Query: 100 VIGIRDILRASTLEAMRDVYIVQDL--METDLYKLLKSQQLSNDHICYFLYQILRGLKYI 157 ++ + +T VY++ + + T +L K + ++ ++ L Y Sbjct: 70 ILRLYGYFHDATR-----VYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYC 124 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 HS V+HRD+KP NLL+ + +LKI DFG + H + T T Y PE++ Sbjct: 125 HSKRVIHRDIKPENLLLGSAGELKIADFGWSV-----HAPSSRRTTLCGTLDYLPPEMIE 179 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 + + + +D+WS+G + E L +P F Y + I + Sbjct: 180 G-RMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRV----------------- 221 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + P A DL+ R+L NP++R + E L HP++ Sbjct: 222 ---EFTFPDF-----------VTEGARDLISRLLKHNPSQRPMLREVLEHPWIT 261 >2Z7Q-A nrPDB Length = 321 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 77/327 (23%), Positives = 133/327 (40%), Gaps = 53/327 (16%) Query: 13 EPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVR---KTRVA 69 +P + EGV + + G + L+ +G+G++G V R A Sbjct: 1 QPSKDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYA 60 Query: 70 IKKISPFEHQ-TYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ET 127 +K + + RT E IL H V+ + + +Y++ D + Sbjct: 61 MKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLH-----YAFQTEGKLYLILDFLRGG 115 Query: 128 DLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFG 186 DL+ L + + + + ++L ++ GL ++HS +++RDLKP N+L++ +K+ DFG Sbjct: 116 DLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFG 175 Query: 187 LARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFP 246 L++ A DH + T Y APE++ N +G++ S D WS G ++ EML+ F Sbjct: 176 LSKEAI---DHEKKAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPFQ 231 Query: 247 GKHYLDQLNHILGI-LGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALD 305 GK + + IL LG P ++A Sbjct: 232 GKDRKETMTLILKAKLGMPQF--------------------------------LSTEAQS 259 Query: 306 LLDRMLTFNPNKRI-----TVEEALAH 327 LL + NP R+ EE H Sbjct: 260 LLRALFKRNPANRLGSGPDGAEEIKRH 286 >2HAK-A nrPDB Length = 328 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 64/321 (19%), Positives = 126/321 (39%), Gaps = 46/321 (14%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHEN 99 Y + IG+G + V A + VA+K I + + T Q+ RE++I+ H N Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 75 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQ-QLSNDHICYFLYQILRGLKYI 157 ++ + +++ E + +Y+V + +++ L + ++ QI+ ++Y Sbjct: 76 IVKLFEVI-----ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 130 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 H ++HRDLK NLL++ ++KI DFG + E L + + Y APE+ Sbjct: 131 HQKYIVHRDLKAENLLLDGDMNIKIADFGFS----NEFTVGNKLDTFCGSPPYAAPELFQ 186 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 K +D+WS+G IL ++S F G++ + +L Sbjct: 187 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR------------------ 228 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 +P L K P KR ++E+ + ++ ++ Sbjct: 229 --GKYRIPFYMSTDCENLLKKLLVLN-----------PIKRGSLEQIMKDRWMNVGHEEE 275 Query: 338 DEP---VAEEPFTFAMELDDL 355 + + F +D + Sbjct: 276 ELKPYTEPDPDFNDTKRIDIM 296 >4QMW-A nrPDB Length = 310 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 79/326 (24%), Positives = 133/326 (40%), Gaps = 44/326 (13%) Query: 8 GGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTR 67 G G E V G+PG ++ +K P ++ +T+L+ IG+G++G V D+ + Sbjct: 1 GPLGSEFMAHSPVQSGLPG-MQNLKADPEEL---FTKLEKIGKGSFGEVFKGIDNRTQKV 56 Query: 68 VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET 127 VAIK I E + + +EI +L + V T ++I+ + + Sbjct: 57 VAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDT-----KLWIIMEYLGG 111 Query: 128 -DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFG 186 LL+ L I L +IL+GL Y+HS +HRD+K +N+L++ ++K+ DFG Sbjct: 112 GSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFG 171 Query: 187 LARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFP 246 +A D +V T ++ APE++ S Y DIWS+G E+ P Sbjct: 172 VAGQLT---DTQIKRNTFVGTPFWMAPEVIKQS-AYDSKADIWSLGITAIELARGEPPHS 227 Query: 247 GKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDL 306 H + L I K L + Sbjct: 228 ELHPMKVLFLI------------------------------PKNNPPTLEGNYSKPLKEF 257 Query: 307 LDRMLTFNPNKRITVEEALAHPYLEQ 332 ++ L P+ R T +E L H ++ + Sbjct: 258 VEACLNKEPSFRPTAKELLKHKFILR 283 >5D7A-A nrPDB Length = 308 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 118/310 (38%), Gaps = 44/310 (14%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF- 95 D + ++ +G G YG V AIK + + + +EI +L ++ Sbjct: 14 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE--EEIKQEINMLKKYS 71 Query: 96 RHENVIGIRDILRASTLEAMRD-VYIVQDLME----TDLYKLLKSQQLSNDHICYFLYQI 150 H N+ M D +++V + TDL K K L + I Y +I Sbjct: 72 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 131 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY 210 LRGL ++H V+HRD+K N+L+ ++K+ DFG++ D G ++ T ++ Sbjct: 132 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT---VGRRNTFIGTPYW 188 Query: 211 RAPEIMLNSKG----YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 APE++ + Y D+WS+G EM P H + L I Sbjct: 189 MAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPR------- 241 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 P W+K F ++ L N ++R E+ + Sbjct: 242 ---------------NPAPRLKSKKWSKKFQS-------FIESCLVKNHSQRPATEQLMK 279 Query: 327 HPYLEQYYDP 336 HP++ + Sbjct: 280 HPFIRDQPNE 289 >5D9K-A nrPDB Length = 330 Score = 237 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 79/371 (21%), Positives = 141/371 (38%), Gaps = 65/371 (17%) Query: 11 GGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRK---TR 67 G P+ E + + +G ++ L+ +G+G++G V Sbjct: 1 GPNPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQL 60 Query: 68 VAIKKISPFEHQ-TYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM- 125 A+K + + RT E IL+ H ++ + + +Y++ D + Sbjct: 61 YAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLH-----YAFQTEGKLYLILDFLR 115 Query: 126 ETDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICD 184 DL+ L + + + + ++L ++ L ++HS +++RDLKP N+L++ +K+ D Sbjct: 116 GGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTD 175 Query: 185 FGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPI 244 FGL++ DH + T Y APE++ N +G+T+S D WS G ++ EML+ Sbjct: 176 FGLSK---ESIDHEKKAYSFCGTVEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGTLP 231 Query: 245 FPGKHYLDQLNHILGI-LGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKA 303 F GK + + IL LG P +A Sbjct: 232 FQGKDRKETMTMILKAKLGMPQF--------------------------------LSPEA 259 Query: 304 LDLLDRMLTFNPNKRITV-----EEALAHPYLE---------QYYDPTDEP---VAEEPF 346 LL + NP R+ EE H + + P +P E+ F Sbjct: 260 QSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTF 319 Query: 347 TFAMELDDLPK 357 F E Sbjct: 320 YFDPEFTAKTP 330 >2UV2-A nrPDB Length = 325 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 73/321 (22%), Positives = 123/321 (38%), Gaps = 45/321 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + + +G+GA+G V A + A K I + + + + EI IL H N++ Sbjct: 39 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVID-TKSEEELEDYMVEIDILASCDHPNIV 97 Query: 102 GIRDILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 + D +++I+ + D L + L+ I Q L L Y+H Sbjct: 98 KLLDAFYYE-----NNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLH 152 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML- 217 ++HRDLK N+L D+K+ DFG++ ++ T ++ APE+++ Sbjct: 153 DNKIIHRDLKAGNILFTLDGDIKLADFGVSA---KNTRTIQRRDSFIGTPYWMAPEVVMC 209 Query: 218 ---NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 + Y D+WS+G L EM P H L+ + +L I S Sbjct: 210 ETSKDRPYDYKADVWSLGITLIEMAEIEPP---HHELNPMRVLLKIAKSEPPTLAQ---- 262 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE-QY 333 W+ F D L + L N + R T + L HP++ Sbjct: 263 --------------PSRWSSNF-------KDFLKKCLEKNVDARWTTSQLLQHPFVTVDS 301 Query: 334 YDPTDEPVAEEPFTFAMELDD 354 P E +AE E++D Sbjct: 302 NKPIRELIAEAKAEVTEEVED 322 >4RLP-A nrPDB Length = 288 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 70/323 (21%), Positives = 130/323 (40%), Gaps = 54/323 (16%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHV---RKTRVAIKKISP---FEHQTYCQRTLREIQIL 92 + L+ +G+G YG V A+K + + T E IL Sbjct: 4 PECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL 63 Query: 93 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ-LSNDHICYFLYQI 150 +H ++ + + +Y++ + + +L+ L+ + D C++L +I Sbjct: 64 EEVKHPFIVDLI-----YAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEI 118 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY 210 L ++H +++RDLKP N+++N +K+ DFGL + + + T + T Y Sbjct: 119 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTH---TFCGTIEY 175 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 APEI++ S G+ +++D WS+G ++ +ML+ P F G++ ++ IL Sbjct: 176 MAPEILMRS-GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK--------- 225 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEAL 325 L P +A DLL ++L N R+ E Sbjct: 226 ----------------------LNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQ 263 Query: 326 AHPYLEQ-YYDPTDEPVAEEPFT 347 AHP+ ++ E PF Sbjct: 264 AHPFFRHINWEELLARKVEPPFK 286 >5YV8-A nrPDB Length = 298 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 73/321 (22%), Positives = 136/321 (42%), Gaps = 63/321 (19%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYC----------------- 82 +YT IG+G+YG+V AY+ T A+K +S + Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 83 --------QRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLL 133 ++ +EI IL + H NV+ + ++L + +Y+V +L+ + ++ Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNED---HLYMVFELVNQGPVMEVP 129 Query: 134 KSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADP 193 + LS D ++ +++G++Y+H ++HRD+KPSNLL+ +KI DFG++ Sbjct: 130 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKG 189 Query: 194 EHDHTGFLTEYVATRWYRAPEIMLNSKG--YTKSIDIWSVGCILAEMLSNRPIFPGKHYL 251 L+ V T + APE + ++ K++D+W++G L + + F Sbjct: 190 SD---ALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF------ 240 Query: 252 DQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRML 311 ++ ++ K ++ P + P DL+ RML Sbjct: 241 --------------MDERIMCLHSKIKSQALEFPDQ---------PDIAEDLKDLITRML 277 Query: 312 TFNPNKRITVEEALAHPYLEQ 332 NP RI V E HP++ + Sbjct: 278 DKNPESRIVVPEIKLHPWVTR 298 >2XIK-A nrPDB Length = 294 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 123/298 (41%), Gaps = 40/298 (13%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 +T+L IG+G++G V D+ K VAIK I E + + +EI +L + + Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 80 Query: 102 GIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSA 160 ST ++I+ + + LLK L +I L +IL+GL Y+HS Sbjct: 81 RYFGSYLKST-----KLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSE 135 Query: 161 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 +HRD+K +N+L++ D+K+ DFG+A D +V T ++ APE++ S Sbjct: 136 RKIHRDIKAANVLLSEQGDVKLADFGVAGQLT---DTQIKRNTFVGTPFWMAPEVIKQS- 191 Query: 221 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNY 280 Y DIWS+G E+ P H + L I Sbjct: 192 AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLI----------------------- 228 Query: 281 LQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTD 338 K + L + + ++ L +P R T +E L H ++ +Y T Sbjct: 229 -------PKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTS 279 >3DB8-A nrPDB Length = 317 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 76/308 (24%), Positives = 127/308 (41%), Gaps = 44/308 (14%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP--FEHQTYCQRTLREIQILLRFR 96 RY + +++G+G + D K A K + ++ EI I Sbjct: 41 MKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLD 100 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRGL 154 + +V+G VY+V ++ L +L K ++ ++ YF+ Q ++G+ Sbjct: 101 NPHVVGFHGFFEDDDF-----VYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGV 155 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 +Y+H+ V+HRDLK NL +N D+KI DFGLA + + + + T Y APE Sbjct: 156 QYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERK---KDLCGTPNYIAPE 212 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 ++ KG++ +DIWS+GCIL +L +P F + I Sbjct: 213 VL-CKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRI----------------- 254 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 334 + S+P + A L+ RML +P R +V E L + Y Sbjct: 255 ---KKNEYSVPR-----------HINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGY 300 Query: 335 DPTDEPVA 342 P P + Sbjct: 301 APMRLPTS 308 >1FOT-A nrPDB Length = 318 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 76/344 (22%), Positives = 140/344 (40%), Gaps = 61/344 (17%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF--EHQTYCQRTLREIQILLRFRHEN 99 + L+ +G G++G V A+K + + T E +L H Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPF 67 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLL-KSQQLSNDHICYFLYQILRGLKYI 157 +I + T + + ++++ D +E +L+ LL KSQ+ N ++ ++ L+Y+ Sbjct: 68 IIRMWG-----TFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYL 122 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 HS ++++RDLKP N+L++ +KI DFG A+ T Y APE++ Sbjct: 123 HSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD------VTYTLCGTPDYIAPEVV- 175 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 ++K Y KSID WS G ++ EML+ F + + IL Sbjct: 176 STKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILN------------------ 217 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEALAHPYLEQ 332 A + P + DLL R++T + ++R+ E+ HP+ ++ Sbjct: 218 -------------AELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKE 264 Query: 333 YY---------DPTDEPVAEEPFTFAMELDDLPKERLKELIFQE 367 + EP ++ + D P+E + + E Sbjct: 265 VVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYPEEDINYGVQGE 308 >3UTO-A nrPDB Length = 573 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 75/340 (22%), Positives = 138/340 (40%), Gaps = 44/340 (12%) Query: 29 EMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLRE 88 + V+ + V Y + +G GA+G+V + A K + H++ + +E Sbjct: 146 QPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVM-TPHESDKETVRKE 204 Query: 89 IQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL--KSQQLSNDHICY 145 IQ + RH ++ + D E ++ ++ + M +L++ + + ++S D Sbjct: 205 IQTMSVLRHPTLVNLHDAF-----EDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVE 259 Query: 146 FLYQILRGLKYIHSANVLHRDLKPSNLLINTT--CDLKICDFGLARIADPEHDHTGFLTE 203 ++ Q+ +GL ++H N +H DLKP N++ T +LK+ DFGL DP+ Sbjct: 260 YMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT-- 317 Query: 204 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS 263 T + APE+ K D+WSVG + +LS F G++ + L ++ Sbjct: 318 --GTAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSC--- 371 Query: 264 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEE 323 D N F D + ++L +PN R+T+ + Sbjct: 372 ----DWNMD--------------------DSAFSGISEDGKDFIRKLLLADPNTRMTIHQ 407 Query: 324 ALAHPYLEQYYDP-TDEPVAEEPFTFAMELDDLPKERLKE 362 AL HP+L P D + +T + + E Sbjct: 408 ALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPE 447 >4FZF-B nrPDB Length = 283 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 119/298 (39%), Gaps = 40/298 (13%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 +T+L+ IG+G++G V D+ + VAIK I E + + +EI +L + V Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 69 Query: 102 GIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSA 160 + ++I+ + + LL++ I L +IL+GL Y+HS Sbjct: 70 KYYGSYLKGS-----KLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSE 124 Query: 161 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 +HRD+K +N+L++ D+K+ FG+A D +V T ++ APE++ S Sbjct: 125 KKIHRDIKAANVLLSEQGDVKLAAFGVAGQLT---DTQIKRNTFVGTPFWMAPEVIQQS- 180 Query: 221 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNY 280 Y DIWS+G E+ P H + L I Sbjct: 181 AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLI----------------------- 217 Query: 281 LQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTD 338 K L + +D L +P+ R T +E L H ++ + T Sbjct: 218 -------PKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTS 268 >2OU7-A nrPDB Length = 335 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 75/299 (25%), Positives = 125/299 (41%), Gaps = 44/299 (14%) Query: 47 YIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 ++G+G + D K A K + S ++ EI I H++V+G Sbjct: 48 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFH 107 Query: 105 DILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANV 162 + V++V +L L +L K ++ L+ Y+L QI+ G +Y+H V Sbjct: 108 GFFEDNDF-----VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 162 Query: 163 LHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 +HRDLK NL +N ++KI DFGLA + + + L T Y APE++ + KG+ Sbjct: 163 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVL---CGTPNYIAPEVL-SKKGH 218 Query: 223 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ 282 + +D+WS+GCI+ +L +P F + I + Sbjct: 219 SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRI--------------------KKNEY 258 Query: 283 SLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPV 341 S+P + A L+ +ML +P R T+ E L + Y P P+ Sbjct: 259 SIPK-----------HINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPI 306 >5J5T-A nrPDB Length = 370 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 79/363 (21%), Positives = 137/363 (37%), Gaps = 63/363 (17%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + +Q IG G YG V A + AIK I + + +EI ++ +H N++ Sbjct: 6 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-VQQEIIMMKDCKHPNIV 64 Query: 102 GIRDILRASTLEAMRDVYIVQDLMET-DLYKLLK-SQQLSNDHICYFLYQILRGLKYIHS 159 + ++I + L + + LS I Y + L+GL Y+HS Sbjct: 65 AYFG-----SYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHS 119 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI--ML 217 +HRD+K +N+L+ +K+ DFG++ ++ T ++ APE+ + Sbjct: 120 KGKMHRDIKGANILLTDNGHVKLADFGVSAQITAT---IAKRKAFIGTPYWMAPEVAAVE 176 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 GY + D+W+VG E+ +P H + L + P + Sbjct: 177 RKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPK----------- 225 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ----- 332 K K+ W+ F + LT NP KR T E+ L HP++ Q Sbjct: 226 --------LKDKMKWSNSFHH-------FVKMALTKNPKKRPTAEKLLQHPFVTQHLTRS 270 Query: 333 ----------------YYDPTD---EPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 373 Y+D D EP+ P ++ +E+ + I +F P Sbjct: 271 LAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDP 330 Query: 374 GVL 376 + Sbjct: 331 PLR 333 >4J52-A nrPDB Length = 293 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 75/299 (25%), Positives = 125/299 (41%), Gaps = 44/299 (14%) Query: 47 YIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 ++G+G + D K A K + S ++ EI I H++V+G Sbjct: 21 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFH 80 Query: 105 DILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANV 162 + V++V +L L +L K ++ L+ Y+L QI+ G +Y+H V Sbjct: 81 GFFEDNDF-----VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 135 Query: 163 LHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 +HRDLK NL +N ++KI DFGLA + + + L T Y APE++ + KG+ Sbjct: 136 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVL---CGTPNYIAPEVL-SKKGH 191 Query: 223 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ 282 + +D+WS+GCI+ +L +P F + I + Sbjct: 192 SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRI--------------------KKNEY 231 Query: 283 SLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPV 341 S+P + A L+ +ML +P R T+ E L + Y P P+ Sbjct: 232 SIPK-----------HINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPI 279 >3KN6-A nrPDB Length = 325 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 129/307 (42%), Gaps = 39/307 (12%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR-HENVIGIR 104 + +GEG++ + A+K IS T +EI L H N++ + Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISK----RMEANTQKEITALKLCEGHPNIVKLH 72 Query: 105 DILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANV 162 ++ ++V +L+ +L++ +K ++ S Y + +++ + ++H V Sbjct: 73 EVFHDQ-----LHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 127 Query: 163 LHRDLKPSNLLI---NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 +HRDLKP NLL N ++KI DFG AR+ P++ L T Y APE +LN Sbjct: 128 VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQ---PLKTPCFTLHYAAPE-LLNQ 183 Query: 220 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN 279 GY +S D+WS+G IL MLS + F + A Sbjct: 184 NGYDESCDLWSLGVILYTMLSGQVPFQSHD--------------------RSLTCTSAVE 223 Query: 280 YLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDE 339 ++ + + + +A DL+ +LT +PNKR+ + + +L+ + Sbjct: 224 IMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSN 283 Query: 340 PVAEEPF 346 P+ Sbjct: 284 PLMTPDI 290 >2JDO-A nrPDB Length = 342 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 67/362 (18%), Positives = 137/362 (37%), Gaps = 68/362 (18%) Query: 34 QPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQI 91 P + L+ +G+G +G V + A+K + + T+ E ++ Sbjct: 4 DPKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRV 63 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQ 149 L RH + ++ + + V + + L + + + + ++ + Sbjct: 64 LQNTRHPFLTALK-----YAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAE 118 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW 209 I+ L+Y+HS +V++RD+K NL+++ +KI DFGL + + + + T Sbjct: 119 IVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDG---ATMKTFCGTPE 175 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 269 Y APE++ ++ Y +++D W +G ++ EM+ R F + + IL Sbjct: 176 YLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL----------- 223 Query: 270 NCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEA 324 M+ + ++L +A LL +L +P +R+ +E Sbjct: 224 -----MEEIRFPRTL---------------SPEAKSLLAGLLKKDPKQRLGGGPSDAKEV 263 Query: 325 LAH------------------PYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQ 366 + H P+ Q D ++ FT A + P +R L Sbjct: 264 MEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFT-AQSITITPPDRYDSLGLL 322 Query: 367 ET 368 E Sbjct: 323 EL 324 >1KOA-A nrPDB Length = 491 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 75/340 (22%), Positives = 138/340 (40%), Gaps = 44/340 (12%) Query: 29 EMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLRE 88 + V+ + V Y + +G GA+G+V + A K + H++ + +E Sbjct: 40 QPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVM-TPHESDKETVRKE 98 Query: 89 IQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL--KSQQLSNDHICY 145 IQ + RH ++ + D E ++ ++ + M +L++ + + ++S D Sbjct: 99 IQTMSVLRHPTLVNLHDAF-----EDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVE 153 Query: 146 FLYQILRGLKYIHSANVLHRDLKPSNLLINTT--CDLKICDFGLARIADPEHDHTGFLTE 203 ++ Q+ +GL ++H N +H DLKP N++ T +LK+ DFGL DP+ Sbjct: 154 YMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT-- 211 Query: 204 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS 263 T + APE+ K D+WSVG + +LS F G++ + L ++ Sbjct: 212 --GTAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSC--- 265 Query: 264 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEE 323 D N F D + ++L +PN R+T+ + Sbjct: 266 ----DWNMD--------------------DSAFSGISEDGKDFIRKLLLADPNTRMTIHQ 301 Query: 324 ALAHPYLEQYYDP-TDEPVAEEPFTFAMELDDLPKERLKE 362 AL HP+L P D + +T + + E Sbjct: 302 ALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPE 341 >3MV5-A nrPDB Length = 342 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 71/354 (20%), Positives = 136/354 (38%), Gaps = 69/354 (19%) Query: 34 QPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQI 91 P + L+ +G+G +G V + A+K + + TL E ++ Sbjct: 4 DPRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 63 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQ 149 L RH + ++ + + + V + + L + + S D ++ + Sbjct: 64 LQNSRHPFLTALK-----YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 118 Query: 150 ILRGLKYIHS-ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 I+ L Y+HS NV++RDLK NL+++ +KI DFGL + + + + T Sbjct: 119 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDG---ATMKTFCGTP 175 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 Y APE++ ++ Y +++D W +G ++ EM+ R F + + IL Sbjct: 176 EYLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL---------- 224 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEE 323 M+ + ++L +A LL +L +P +R+ +E Sbjct: 225 ------MEEIRFPRTLG---------------PEAKSLLSGLLKKDPKQRLGGGSEDAKE 263 Query: 324 ALAH------------------PYLEQYYDPTDEPVAEEPFTFAMELDDLPKER 359 + H P+ Q TD +E FT A + P ++ Sbjct: 264 IMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT-AQMITITPPDQ 316 >2WO6-A nrPDB Length = 382 Score = 231 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 92/350 (26%), Positives = 153/350 (43%), Gaps = 56/350 (16%) Query: 30 MVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREI 89 + G+ + RY IG+G++G V AYD V + VAIK I + + + E+ Sbjct: 46 VKNGEKW--MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKN--KKAFLNQAQIEV 101 Query: 90 QILLRFR-HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQL---SNDHICY 145 ++L H+ + + + +V +++ +LY LL++ S + Sbjct: 102 RLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRK 161 Query: 146 FLYQILRGLKYIH--SANVLHRDLKPSNLLINT--TCDLKICDFGLARIADPEHDHTGFL 201 F Q+ L ++ +++H DLKP N+L+ +KI DFG + Sbjct: 162 FAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQ---- 217 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 261 Y+ +R+YR+PE++L Y +ID+WS+GCIL EM + P+F G + +DQ+N I+ +L Sbjct: 218 --YIQSRFYRSPEVLLG-MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVL 274 Query: 262 GSPSQEDLNCIINMKARNYLQSLP------SKTKVAWAKLFPKSDSKA------------ 303 G P L+ KAR + + LP KTK + P K Sbjct: 275 GIPPAHILDQA--PKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPG 332 Query: 304 -----------------LDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 DL+ RML ++P RI AL H + ++ D Sbjct: 333 GRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >1VZO-A nrPDB Length = 355 Score = 230 bits (586), Expect = 8e-61, Method: Composition-based stats. Identities = 77/366 (21%), Positives = 150/366 (40%), Gaps = 59/366 (16%) Query: 4 AAAQGGGGGEPRRT---EGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60 +A GG GGE T E + G E V + F L+ +G GAYG V Sbjct: 21 TSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENF------ELLKVLGTGAYGKVFLVR 74 Query: 61 D---HVRKTRVAIKKISP---FEHQTYCQRTLREIQILLRFRH-ENVIGIRDILRASTLE 113 H A+K + + + T E Q+L R ++ + + T Sbjct: 75 KISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTET-- 132 Query: 114 AMRDVYIVQDLM-ETDLYKLL-KSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSN 171 ++++ D + +L+ L + ++ + + ++ +I+ L+++H +++RD+K N Sbjct: 133 ---KLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLEN 189 Query: 172 LLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK-GYTKSIDIWS 230 +L+++ + + DFGL++ D T ++ T Y AP+I+ G+ K++D WS Sbjct: 190 ILLDSNGHVVLTDFGLSKEFVA--DETERAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWS 247 Query: 231 VGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKV 290 +G ++ E+L+ F + I +R L+S P + Sbjct: 248 LGVLMYELLTGASPFTVDGEKNSQAEI-------------------SRRILKSEPPYPQ- 287 Query: 291 AWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEALAHPYLEQ-YYDPTDEPVAEE 344 + + A DL+ R+L +P KR+ +E H + ++ +D Sbjct: 288 -------EMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPA 340 Query: 345 PFTFAM 350 PF + Sbjct: 341 PFKPVI 346 >3HDN-A nrPDB Length = 373 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 67/330 (20%), Positives = 131/330 (39%), Gaps = 50/330 (15%) Query: 32 KGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREI 89 P + L+ IG+G++G V A + A+K + + + + E Sbjct: 30 SSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER 89 Query: 90 QIL-LRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYF 146 +L +H ++G+ + + +Y V D + Y L + + ++ Sbjct: 90 NVLLKNVKHPFLVGLH-----FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFY 144 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 +I L Y+HS N+++RDLKP N+L+++ + + DFGL + +H + + Sbjct: 145 AAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCK---ENIEHNSTTSTFCG 201 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 T Y APE++ + + Y +++D W +G +L EML P F ++ + ++IL Sbjct: 202 TPEYLAPEVL-HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN------- 253 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVE---- 322 +L P + A LL+ +L + KR+ + Sbjct: 254 ------------------------KPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFM 289 Query: 323 EALAHPYLE-QYYDPTDEPVAEEPFTFAME 351 E +H + +D PF + Sbjct: 290 EIKSHVFFSLINWDDLINKKITPPFNPNVS 319 >4WNO-A nrPDB Length = 287 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 82/336 (24%), Positives = 133/336 (39%), Gaps = 65/336 (19%) Query: 8 GGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKT- 66 GGG EP R G G+ E +++ IG GA+ +V Sbjct: 1 GGGSMEPGRG---GTETVGKFE------------FSRKDLIGHGAFAVVFKGRHRAAHDL 45 Query: 67 RVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM- 125 VA+K I+ +EI+IL +HEN++ + D E VY+V + Sbjct: 46 EVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDF-----QEMANSVYLVMEYCN 100 Query: 126 ETDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN--------- 175 DL L + + LS D I FL QI ++ +HS ++HRDLKP N+L++ Sbjct: 101 GGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANP 160 Query: 176 TTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL 235 + +KI DFG AR + Y APE+++ S+ Y D+WS+G I+ Sbjct: 161 NSIRVKIADFGFARYLQSNM----MAATLCGSPMYMAPEVIM-SQHYDGKADLWSIGTIV 215 Query: 236 AEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKL 295 + L+ + F D + K + + ++P +T +L Sbjct: 216 YQCLTGKAPFQASSPQDL-----------------RLFYEKNKTLVPTIPRETSAPLRQL 258 Query: 296 FPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + N R+ +E HP+L+ Sbjct: 259 LLALLQR-----------NHKDRMDFDEFFHHPFLD 283 >5X8I-B nrPDB Length = 346 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 91/333 (27%), Positives = 141/333 (42%), Gaps = 48/333 (14%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRK-TRVAIKKISPFEHQTYCQRTLREIQILLRF 95 + RY + +GEGA+G V DH VA+K + + YC+ EIQ+L Sbjct: 10 VLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVD--RYCEAARSEIQVLEHL 67 Query: 96 R--HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ---QLSNDHICYFLYQI 150 N R + E + IV +L+ Y +K DHI YQI Sbjct: 68 NTTDPNST-FRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQI 126 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINT-------------------TCDLKICDFGLARIA 191 + + ++HS + H DLKP N+L D+K+ DFG A Sbjct: 127 CKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYD 186 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 251 D H + V+TR YRAPE++L + G+++ D+WS+GCIL E +FP Sbjct: 187 DEHH------STLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSK 239 Query: 252 DQLNHILGILGSPSQEDLNCIINMKARNYLQ----------SLPSKTKVAWAKLFPKSDS 301 + L + ILG + + K ++ + S+ + D Sbjct: 240 EHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDV 299 Query: 302 K---ALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + DL+ +ML ++P KRIT+ EAL HP+ + Sbjct: 300 EHERLFDLIQKMLEYDPAKRITLREALKHPFFD 332 >1KOB-A nrPDB Length = 387 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 76/341 (22%), Positives = 138/341 (40%), Gaps = 44/341 (12%) Query: 24 VPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ 83 VP VE+ +G +D Y L+ +G GA+G+V + K I+ + Sbjct: 38 VPQPVEVKQGSVYDY---YDILEELGSGAFGVVHRCVEKATGRVFVAKFIN-TPYPLDKY 93 Query: 84 RTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL--KSQQLSND 141 EI I+ + H +I + D + V I++ L +L+ + + ++S Sbjct: 94 TVKNEISIMNQLHHPKLINLHDAFE----DKYEMVLILEFLSGGELFDRIAAEDYKMSEA 149 Query: 142 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT--CDLKICDFGLARIADPEHDHTG 199 + ++ Q GLK++H +++H D+KP N++ T +KI DFGLA +P+ Sbjct: 150 EVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDE---- 205 Query: 200 FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 259 + AT + APEI+ + + D+W++G + +LS F G+ L+ L ++ Sbjct: 206 IVKVTTATAEFAAPEIV-DREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNV-K 263 Query: 260 ILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI 319 ED F +A D + +L P KR+ Sbjct: 264 RCDWEFDED--------------------------AFSSVSPEAKDFIKNLLQKEPRKRL 297 Query: 320 TVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL 360 TV +AL HP+L+ + + + + Sbjct: 298 TVHDALEHPWLKGDHSNLTSRIPSSRYNKIRQKIKEKYADW 338 >2OZA-A nrPDB Length = 356 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 75/363 (20%), Positives = 144/363 (39%), Gaps = 48/363 (13%) Query: 21 GPGVPGEVEMVKGQPFDVGPRYTQL-QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQ 79 G V +++ K + Y Q +G G G V ++ + + A+K + Sbjct: 1 GSHVKSGLQIKKNA---IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------ 51 Query: 80 TYCQRTLREIQILLRFRH-ENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ 137 C + RE+++ R +++ I D+ + + IV + ++ +L+ ++ + Sbjct: 52 QDCPKARREVELHWRASQCPHIVRIVDVYENL-YAGRKCLLIVMECLDGGELFSRIQDRG 110 Query: 138 ---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT---TCDLKICDFGLARIA 191 + + I ++Y+HS N+ HRD+KP NLL + LK+ DFG A+ Sbjct: 111 DQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-- 168 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 251 E LT T +Y APE++ + Y KS D+WS+G I+ +L P F H L Sbjct: 169 --ETTSHNSLTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL 225 Query: 252 DQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRML 311 ++ + + R P+ + + + L+ +L Sbjct: 226 ----------------AISPGMKTRIRMGQYEFPNPE-------WSEVSEEVKMLIRNLL 262 Query: 312 TFNPNKRITVEEALAHPYLEQYYDPTDEPV-AEEPFTFAMELDDLPKERLKELIFQETAR 370 P +R+T+ E + HP++ Q P+ E + KE + + Sbjct: 263 KTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVD 322 Query: 371 FQP 373 ++ Sbjct: 323 YEQ 325 >3HKO-A nrPDB Length = 345 Score = 227 bits (579), Expect = 6e-60, Method: Composition-based stats. Identities = 74/353 (20%), Positives = 135/353 (38%), Gaps = 82/353 (23%) Query: 33 GQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE----HQTYCQRTLRE 88 G ++ +Y IG+G+YG+V A ++ + AIK ++ + + +R E Sbjct: 19 GSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTE 78 Query: 89 IQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLK------------- 134 ++++ + H N+ + ++ E + + +V +L L L Sbjct: 79 VRLMKKLHHPNIARLYEVY-----EDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMD 133 Query: 135 ------------------------SQQLS----NDHICYFLYQILRGLKYIHSANVLHRD 166 + L I + QI L Y+H+ + HRD Sbjct: 134 VVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRD 193 Query: 167 LKPSNLLINTT--CDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIM-LNSKGY 222 +KP N L +T ++K+ DFGL++ + +T T ++ APE++ ++ Y Sbjct: 194 IKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESY 253 Query: 223 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ 282 D WS G +L +L FPG + D ++ + LN + + NY Sbjct: 254 GPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQV-----------LNKKLCFENPNY-- 300 Query: 283 SLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 335 A DLL +L N ++R AL HP++ Q+ D Sbjct: 301 --------------NVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSD 339 >5DYK-A nrPDB Length = 853 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 83/354 (23%), Positives = 141/354 (39%), Gaps = 56/354 (15%) Query: 20 VGPGVPGEVEMVKGQPFDV-GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE- 77 GP + E +K Q V + IG G +G V + K R A+K +S Sbjct: 518 QGPMLAHLEERIKMQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSI 577 Query: 78 -HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKS 135 + E +I H +I + T + + Y + +L+ +LY ++ Sbjct: 578 INLNQQNNIKLEREITAENDHPFIIRLV-----RTFKDSKYFYFLTELVTGGELYDAIRK 632 Query: 136 -QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPE 194 LS ++L I+ ++Y+H N+++RDLKP N+L++ +K+ DFG A+ Sbjct: 633 LGLLSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKV--- 689 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 G V T Y APE++L KGY ++DIW++G L E + F G DQL Sbjct: 690 ---QGRAYTLVGTPHYMAPEVILG-KGYGCTVDIWALGICLYEFICGPLPF-GNDEEDQL 744 Query: 255 NHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFN 314 IL + P +D+ +++L+ R+L Sbjct: 745 EIFRDIL-----------------TGQLTFPDYV----------TDTDSINLMKRLLCRL 777 Query: 315 PNKRITV-----EEALAHPYLEQYY------DPTDEPVAEEPFTFAMELDDLPK 357 P RI ++ HP+ + D P+ + T+A ++D Sbjct: 778 PQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKSETYAEDIDIKQI 831 >6FYV-A nrPDB Length = 337 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 89/333 (26%), Positives = 139/333 (41%), Gaps = 48/333 (14%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDH-VRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95 + RY + +GEGA+G V DH + VA+K + Y + EIQ+L Sbjct: 11 VLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVG--RYREAARSEIQVLEHL 68 Query: 96 RH--ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ---QLSNDHICYFLYQI 150 N + R + + V IV +L+ Y +K DHI YQI Sbjct: 69 NSTDPNSV-FRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQI 127 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINT-------------------TCDLKICDFGLARIA 191 + + ++H + H DLKP N+L D+K+ DFG A Sbjct: 128 CQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYD 187 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 251 D H + V+TR YRAPE++L + G+++ D+WS+GCIL E +F Sbjct: 188 DEHH------STLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSK 240 Query: 252 DQLNHILGILGSPSQEDLNCIINMKARNYLQ----------SLPSKTKVAWAKLFPKSDS 301 + L + ILG Q + K ++ Q + + D Sbjct: 241 EHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDE 300 Query: 302 K---ALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + DL+ RML ++P +RIT++EAL HP+ + Sbjct: 301 EHEKLFDLVRRMLEYDPTQRITLDEALQHPFFD 333 >1NY3-A nrPDB Length = 400 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 71/337 (21%), Positives = 136/337 (40%), Gaps = 44/337 (13%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-ENVIGIR 104 Q +G G G V ++ + + A+K + C + RE+++ R +++ I Sbjct: 68 QVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQCPHIVRIV 121 Query: 105 DILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ---LSNDHICYFLYQILRGLKYIHSA 160 D+ + + IV + ++ +L+ ++ + + + I ++Y+HS Sbjct: 122 DVYENL-YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 Query: 161 NVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 N+ HRD+KP NLL + LK+ DFG A+ E LT T +Y APE++ Sbjct: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTTPCYTPYYVAPEVL- 235 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 + Y KS D+WS+G I+ +L P F H L ++ + + Sbjct: 236 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL----------------AISPGMKTRI 279 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 R P+ + + + L+ +L P +R+T+ E + HP++ Q Sbjct: 280 RMGQYEFPNPE-------WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP 332 Query: 338 DEPV-AEEPFTFAMELDDLPKERLKELIFQETARFQP 373 P+ E + KE + + ++ Sbjct: 333 QTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQ 369 >5X3F-B nrPDB Length = 393 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 70/339 (20%), Positives = 132/339 (38%), Gaps = 60/339 (17%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFRH 97 ++ +++ +G G++G V A+K + + + TL E +IL Sbjct: 84 DQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 143 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKS-QQLSNDHICYFLYQILRGLK 155 ++ + + + ++Y+V + + +++ L+ + S H ++ QI+ + Sbjct: 144 PFLVKL-----EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 198 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 Y+HS ++++RDLKP NLLI+ +++ DFG A+ G T Y APEI Sbjct: 199 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK------GRTWTLCGTPEYLAPEI 252 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 +L SKGY K++D W++G ++ EM + P F + I+ Sbjct: 253 IL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK-------------- 297 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEALAHPYL 330 + S DLL +L + KR V + H + Sbjct: 298 -----------------VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 340 Query: 331 -EQYYDPTDEPVAEEPFTFAM-------ELDDLPKERLK 361 + + E PF DD +E ++ Sbjct: 341 ATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIR 379 >6CQF-A nrPDB Length = 297 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 78/310 (25%), Positives = 129/310 (41%), Gaps = 41/310 (13%) Query: 29 EMVKGQPFDVGPR--YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTL 86 ++V F+ PR Y LQ +G G YG V A D V VA+K + E Sbjct: 3 DVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK-MEPDDDVSTLQ 61 Query: 87 REIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLK-SQQLSNDHIC 144 +EI IL RH N++ ++ ++I + L + + + LS I Sbjct: 62 KEILILKTCRHANIVAYHGSYLW-----LQKLWICMEFCGAGSLQDIYQVTGSLSELQIS 116 Query: 145 YFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEY 204 Y ++L+GL Y+HS +HRD+K +N+LIN ++++ DFG++ + Sbjct: 117 YVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQI---GATLARRLAF 173 Query: 205 VATRWYRAPEI--MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILG 262 + T ++ APE+ + GY + DIWS+G E+ +P H L L + Sbjct: 174 IGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGY 233 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVE 322 P + K K W+ F + + LT +P KR + Sbjct: 234 QPPR-------------------LKEKGKWSAAFH-------NFIKVTLTKSPKKRPSAT 267 Query: 323 EALAHPYLEQ 332 + L+H + Q Sbjct: 268 KMLSHQLVSQ 277 >3ORZ-A nrPDB Length = 316 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 75/336 (22%), Positives = 129/336 (38%), Gaps = 52/336 (15%) Query: 7 QGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKT 66 G EPR G + K +P D + + +GEG++ V A + Sbjct: 8 MDGTAAEPRPGAGSLQHAQPPPQPRKKRPED----FKFGKILGEGSFSTVVLARELATSR 63 Query: 67 RVAIKKISPFE--HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDL 124 AIK + + RE ++ R H + + + +Y Sbjct: 64 EYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLY-----FCFQDDEKLYFGLSY 118 Query: 125 M-ETDLYKLLKS-QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKI 182 +L K ++ ++ +I+ L+Y+H ++HRDLKP N+L+N ++I Sbjct: 119 AKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQI 178 Query: 183 CDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 242 DFG A++ PE +V T Y +PE++ KS D+W++GCI+ ++++ Sbjct: 179 TDFGTAKVLSPESKQ-ARANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGL 236 Query: 243 PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSK 302 P F + I+ P K FP K Sbjct: 237 PPFRAGNEYLIFQKIIK--------------------LEYDFPEK-------FFP----K 265 Query: 303 ALDLLDRMLTFNPNKRITVEE------ALAHPYLEQ 332 A DL++++L + KR+ EE AHP+ E Sbjct: 266 ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFES 301 >3KA0-A nrPDB Length = 320 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 72/328 (21%), Positives = 135/328 (41%), Gaps = 44/328 (13%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-ENVIGIR 104 Q +G G G V ++ + + A+K + C + RE+++ R +++ I Sbjct: 22 QVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQCPHIVRIV 75 Query: 105 DILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ---LSNDHICYFLYQILRGLKYIHSA 160 D+ + + IV + ++ +L+ ++ + + + I ++Y+HS Sbjct: 76 DVYENL-YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 134 Query: 161 NVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 N+ HRD+KP NLL + LK+ DFG A+ E LTE T +Y APE++ Sbjct: 135 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTEPCYTPYYVAPEVL- 189 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 + Y KS D+WS+G I+ +L P F H L ++ + + Sbjct: 190 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL----------------AISPGMKTRI 233 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 337 R P+ + + + L+ +L P +R+T+ E + HP++ Q Sbjct: 234 RMGQYEFPNPE-------WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP 286 Query: 338 DEPV-AEEPFTFAMELDDLPKERLKELI 364 P+ E + KE + + Sbjct: 287 QTPLHTSRVLKEDKERWEDVKEEMTSAL 314 >6E9W-A nrPDB Length = 443 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 74/333 (22%), Positives = 126/333 (37%), Gaps = 47/333 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTL--REIQILLRFRHEN 99 Y ++ IG GA+G V + A+K +S FE E I+ Sbjct: 104 YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW 163 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 V+ + + R +Y+V + M DL L+ + + ++ +++ L IH Sbjct: 164 VVQLF-----YAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIH 218 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML- 217 S +HRD+KP N+L++ + LK+ DFG + E V T Y +PE++ Sbjct: 219 SMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEG--MVRCDTAVGTPDYISPEVLKS 276 Query: 218 --NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 Y + D WSVG L EML F + + I+ S + D N I Sbjct: 277 QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDI--- 333 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI---TVEEALAHPYLEQ 332 +A +L+ LT + R+ VEE H + + Sbjct: 334 ------------------------SKEAKNLICAFLT-DREVRLGRNGVEEIKRHLFFKN 368 Query: 333 Y---YDPTDEPVAEEPFTFAMELDDLPKERLKE 362 ++ + VA + ++D + L+E Sbjct: 369 DQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEE 401 >2BRG-A nrPDB Length = 297 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 75/293 (25%), Positives = 127/293 (43%), Gaps = 36/293 (12%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + +Q +GEGAYG V A + V + VA+K + + +EI I HENV+ Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVV 68 Query: 102 GIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQ-QLSNDHICYFLYQILRGLKYIHS 159 R ++ Y+ + +L+ ++ + F +Q++ G+ Y+H Sbjct: 69 KFYGHRREGNIQ-----YLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 + HRD+KP NLL++ +LKI DFGLA + ++ L + T Y APE++ Sbjct: 124 IGITHRDIKPENLLLDERDNLKISDFGLATVFR-YNNRERLLNKMCGTLPYVAPELLKRR 182 Query: 220 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN 279 + + + +D+WS G +L ML+ DQ PS + + Sbjct: 183 EFHAEPVDVWSCGIVLTAMLAGELP------WDQ----------PSDSCQEYSDWKEKKT 226 Query: 280 YLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 YL + K DS L LL ++L NP+ RIT+ + + + Sbjct: 227 YLNP------------WKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNK 267 >5XVU-A nrPDB Length = 332 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 88/312 (28%), Positives = 157/312 (50%), Gaps = 21/312 (6%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 ++ RY ++ IG G Y V + YD A ++ REI+IL Sbjct: 26 QWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA----IKVLKPVKKKKIKREIKILQN 81 Query: 95 FRH-ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 N+I + DI++ + ++ + + +K L + ++ I Y++YQIL+ Sbjct: 82 LNGGPNIIKLLDIVKDPVTKTPS---LIFEYINNIDFKTL-YPKFTDKDIRYYIYQILKA 137 Query: 154 LKYIHSANVLHRDLKPSNLLIN-TTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 L Y HS ++HRD+KP N++I+ +++ +GLA P ++ VA+R+Y+ Sbjct: 138 LDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNV----RVASRYYKG 193 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNC 271 PE++++ + Y S+DIWS+GC+LA M+ + P F G DQL I +LG+ Sbjct: 194 PELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLK 253 Query: 272 IINMKAR-NYLQSLPSKTKVAWAKLFPKSD-----SKALDLLDRMLTFNPNKRITVEEAL 325 N+K + +YL L + W+ +S+ + +DL+D+ML ++ KRI +EA+ Sbjct: 254 KYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAM 313 Query: 326 AHPYLEQYYDPT 337 HPY + + + Sbjct: 314 EHPYFREVREES 325 >3FXW-A nrPDB Length = 336 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 70/356 (19%), Positives = 138/356 (38%), Gaps = 61/356 (17%) Query: 22 PGVPGEVEMVKGQPFDVGPRYTQLQ-YIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQT 80 G+ + + + + V Y + +G G G V + + A+K + Sbjct: 10 SGLEVLFQGPEPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL------Y 63 Query: 81 YCQRTLREIQILLRFRH------ENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLL 133 + +E+ H +++ I D+ R + I+ + ME +L+ + Sbjct: 64 DSPKARQEVD-----HHWQASGGPHIVCILDVYENM-HHGKRCLLIIMECMEGGELFSRI 117 Query: 134 KSQQ---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT---TCDLKICDFGL 187 + + + + I ++++HS N+ HRD+KP NLL + LK+ DFG Sbjct: 118 QERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGF 177 Query: 188 ARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 247 A+ L T +Y APE++ + Y KS D+WS+G I+ +L P F Sbjct: 178 AK-----ETTQNALQTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYS 231 Query: 248 KHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLL 307 + + ++ + + R P+ + + A L+ Sbjct: 232 N----------------TGQAISPGMKRRIRLGQYGFPNPE-------WSEVSEDAKQLI 268 Query: 308 DRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKEL 363 +L +P +R+T+ + + HP++ Q V + P A L + K+ E+ Sbjct: 269 RLLLKTDPTERLTITQFMNHPWINQ-----SMVVPQTPLHTARVLQE-DKDHWDEV 318 >6ED6-A nrPDB Length = 415 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 73/331 (22%), Positives = 123/331 (37%), Gaps = 47/331 (14%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTL--REIQILLRFRHEN 99 Y ++ IG GA+G V + A+K +S FE E I+ Sbjct: 90 YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW 149 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 V+ + + R +Y+V + M DL L+ + + ++ +++ L IH Sbjct: 150 VVQLF-----YAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIH 204 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 S ++HRD+KP N+L++ LK+ DFG D V T Y +PE++ + Sbjct: 205 SMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETG--MVHCDTAVGTPDYISPEVLKS 262 Query: 219 SKG---YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 G Y + D WSVG L EML F + + I+ S Sbjct: 263 QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLC---------- 312 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI---TVEEALAHPYLEQ 332 P + A +L+ LT + R+ VEE HP+ + Sbjct: 313 --------FPEDA---------EISKHAKNLICAFLT-DREVRLGRNGVEEIRQHPFFKN 354 Query: 333 ---YYDPTDEPVAEEPFTFAMELDDLPKERL 360 ++D E A + ++D + + Sbjct: 355 DQWHWDNIRETAAPVVPELSSDIDSSNFDDI 385 >4WB7-A nrPDB Length = 405 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 70/339 (20%), Positives = 132/339 (38%), Gaps = 60/339 (17%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFRH 97 ++ +++ +G G++G V A+K + + + TL E +IL Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 155 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKS-QQLSNDHICYFLYQILRGLK 155 ++ + + + ++Y+V + + +++ L+ + S H ++ QI+ + Sbjct: 156 PFLVKL-----EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 210 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 Y+HS ++++RDLKP NLLI+ +++ DFG A+ G T Y APEI Sbjct: 211 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK------GRTWTLCGTPEYLAPEI 264 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 +L SKGY K++D W++G ++ EM + P F + I+ Sbjct: 265 IL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK-------------- 309 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEALAHPYL 330 + S DLL +L + KR V + H + Sbjct: 310 -----------------VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 352 Query: 331 -EQYYDPTDEPVAEEPFTFAM-------ELDDLPKERLK 361 + + E PF DD +E ++ Sbjct: 353 ATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIR 391 >6HXF-B nrPDB Length = 302 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 113/303 (37%), Gaps = 44/303 (14%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 D + + +G+GA+G V A + A K I + + + + EI+IL Sbjct: 16 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVI-ETKSEEELEDYIVEIEILATCD 74 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK---SQQLSNDHICYFLYQILRG 153 H ++ + ++I+ + + + L+ I Q+L Sbjct: 75 HPYIVKLLGAYYHDG-----KLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEA 129 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 L ++HS ++HRDLK N+L+ D+++ DFG++ ++ T ++ AP Sbjct: 130 LNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSA---KNLKTLQKRDSFIGTPYWMAP 186 Query: 214 EIM----LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 269 E++ + Y DIWS+G L EM P H L+ + +L I S L Sbjct: 187 EVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPP---HHELNPMRVLLKIAKSDPPTLL 243 Query: 270 NCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY 329 K + D L L NP R + + L HP+ Sbjct: 244 TP-------------------------SKWSVEFRDFLKIALDKNPETRPSAAQLLEHPF 278 Query: 330 LEQ 332 + Sbjct: 279 VSS 281 >3TXO-A nrPDB Length = 353 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 63/339 (18%), Positives = 126/339 (37%), Gaps = 56/339 (16%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFR- 96 + ++ +G+G++G V A A+K + + T+ E +IL R Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGL 154 H + + + ++ V + + ++ + KS++ ++ +I+ L Sbjct: 83 HPFLTQLF-----CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 137 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 ++H +++RDLK N+L++ K+ DFG+ + + + T Y APE Sbjct: 138 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCK---EGICNGVTTATFCGTPDYIAPE 194 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 I+ Y ++D W++G +L EML F ++ D IL Sbjct: 195 IL-QEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAIL---------------- 237 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-TVEE-----ALAHP 328 N P+ A +L +T NP R+ ++ + L HP Sbjct: 238 ----NDEVVYPTW-----------LHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHP 282 Query: 329 YLE-----QYYDPTDEPVAEEPFTFAMELDDLPKERLKE 362 + + Q EP ++ + + +KE Sbjct: 283 FFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKE 321 >2WTK-C nrPDB Length = 305 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 77/332 (23%), Positives = 132/332 (39%), Gaps = 49/332 (14%) Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ---RTLREIQILLRFRH 97 +Y +GEG+YG V D R A+K + + + +EIQ+L R RH Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS---QQLSNDHICYFLYQILRGL 154 +NVI + D+L E + +Y+V + + ++L S ++ + Q++ GL Sbjct: 66 KNVIQLVDVLYN---EEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGL 122 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 +Y+HS ++H+D+KP NLL+ T LKI G+A P T + ++ PE Sbjct: 123 EYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQ-GSPAFQPPE 181 Query: 215 IMLNSKGY-TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 I + +DIWS G L + + F G + +I Sbjct: 182 IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENI---------------- 225 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 ++P + DLL ML + P KR ++ + H + + Sbjct: 226 ----GKGSYAIPGDCGPPLS-----------DLLKGMLEYEPAKRFSIRQIRQHSWFRKK 270 Query: 334 YDPTDEPVAEEPFTFAMELDDLPKERLKELIF 365 + P + PV P K+R + + Sbjct: 271 HPPAEAPVPIPPSPD-------TKDRWRSMTV 295 >4U41-A nrPDB Length = 332 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 70/330 (21%), Positives = 124/330 (37%), Gaps = 44/330 (13%) Query: 17 TEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF 76 V++ D + ++ +G G YG V AIK + Sbjct: 1 GSANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVT 60 Query: 77 EHQTYCQRTLREIQILLRF-RHENVIGIRD-ILRASTLEAMRDVYIVQDLME----TDLY 130 E + + EI +L ++ H N+ ++ S +++V + TDL Sbjct: 61 EDEEEEIKL--EINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLV 118 Query: 131 KLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARI 190 K K L D I Y +ILRGL ++H +V+HRD+K N+L+ ++K+ DFG++ Sbjct: 119 KNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQ 178 Query: 191 ADPEHDHTGFLTEYVATRWYRAPEIMLNSKG----YTKSIDIWSVGCILAEMLSNRPIFP 246 D G ++ T ++ APE++ + Y D+WS G EM P Sbjct: 179 LDRT---VGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLC 235 Query: 247 GKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDL 306 H + L I +P + + K ++ Sbjct: 236 DMHPMRALFLIPR---NPPPRLKSKKWSKKFFSF-------------------------- 266 Query: 307 LDRMLTFNPNKRITVEEALAHPYLEQYYDP 336 ++ L N +R + E+ L HP++ + Sbjct: 267 IEGCLVKNYMQRPSTEQLLKHPFIRDQPNE 296 >4CSV-A nrPDB Length = 275 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 58/289 (20%), Positives = 113/289 (39%), Gaps = 45/289 (15%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 T + +G G +G V VA+K + E + L+E QI+ + +H N++ Sbjct: 14 TLERKLGSGQFGEVYEGKWRNYNIEVAVKTLK--EGTMSVEEFLQEAQIMKKLKHPNLVQ 71 Query: 103 IRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKS---QQLSNDHICYFLYQILRGLKYIH 158 + + +YI+ + M L L+ ++ + Q+ G+ Y+ Sbjct: 72 LYGVCTKE-----PPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLE 126 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 S N +HRDL N L+ +K+ DFGLAR+ + E ++T +W APE + Sbjct: 127 SQNFIHRDLAARNCLVGENNVVKVADFGLARLIN-EDEYTARAGAKFPIKW-TAPEAISY 184 Query: 219 SKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 ++ ++ D+W+ G +L E+ + + +PG + + + P + Sbjct: 185 NR-FSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQ---------- 233 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 + +L+ + +P +R T E L Sbjct: 234 --------------------GCPEEIYELMLQCWNKSPEERPTFAETLH 262 >6QAU-A nrPDB Length = 280 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 81/315 (25%), Positives = 131/315 (41%), Gaps = 51/315 (16%) Query: 33 GQPFDVGP-RYTQLQYIGEGAYGMVSSAYDHV-RKTRVAIKKISPFEHQTYCQRTLREIQ 90 G VG Y++ +G GA+ +V VAIK I+ +EI+ Sbjct: 3 GSMEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIK 62 Query: 91 ILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ-LSNDHICYFLY 148 IL +HEN++ + D+ E V++V + DL L+++ LS D I FL+ Sbjct: 63 ILKELQHENIVALYDV-----QELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLH 117 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLIN---------TTCDLKICDFGLARIADPEHDHTG 199 QI ++ +HS ++HRDLKP N+L++ + +KI DFG AR Sbjct: 118 QIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNM---- 173 Query: 200 FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 259 + + Y APE+++ S+ Y D+WS+G ++ + L +P F D Sbjct: 174 MAADLCGSPMYMAPEVIM-SQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDL------ 226 Query: 260 ILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI 319 + K R+ + S+P +T A L N R+ Sbjct: 227 -----------RMFYEKNRSLMPSIPRETSPYLANLLLGLL-----------QRNQKDRM 264 Query: 320 TVEEALAHPYLEQYY 334 E +HP+LEQ Sbjct: 265 DFEAFFSHPFLEQGP 279 >5N23-A nrPDB Length = 352 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 70/339 (20%), Positives = 130/339 (38%), Gaps = 59/339 (17%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFRH 97 ++ +++ +G G++G V A+K + + + TL E +I Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNF 101 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKS-QQLSNDHICYFLYQILRGLK 155 ++ + + + ++Y+V + +++ L+ + S H ++ QI+ + Sbjct: 102 PFLVKL-----EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 Y+HS ++++RDLKP NLLI+ +K+ DFG A+ T T Y APEI Sbjct: 157 YLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWT-----LCGTPEYLAPEI 211 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 +L SKGY K++D W++G ++ EM + P F + I+ Sbjct: 212 IL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK-------------- 256 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEALAHPYL 330 + S DLL +L + KR V + H + Sbjct: 257 -----------------VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 299 Query: 331 -EQYYDPTDEPVAEEPFTFAM-------ELDDLPKERLK 361 + + E PF DD +E ++ Sbjct: 300 ATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIR 338 >5F9E-A nrPDB Length = 353 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 74/321 (23%), Positives = 128/321 (39%), Gaps = 55/321 (17%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRF-RHE 98 + + +G+G++G V A AIK + + T+ E ++L H Sbjct: 21 FELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP 80 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGLKY 156 + + T + +++ V + + +Y + + ++ +I+ GL++ Sbjct: 81 FLTHMF-----CTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQF 135 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 +HS +++RDLK N+L++ +KI DFG+ + T E+ T Y APEI+ Sbjct: 136 LHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKT---NEFCGTPDYIAPEIL 192 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 L K Y S+D WS G +L EML + F G+ E+L I M Sbjct: 193 LGQK-YNHSVDWWSFGVLLYEMLIGQSPFHGQDE----------------EELFHSIRMD 235 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVE-EALAHPYL----- 330 Y + L + +A DLL ++ P KR+ V + HP Sbjct: 236 NPFYPRWL---------------EKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINW 280 Query: 331 ----EQYYDPTDEPVAEEPFT 347 + DP P + PF Sbjct: 281 EELERKEIDPPFRPKVKSPFD 301 >5FET-A nrPDB Length = 847 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 85/356 (23%), Positives = 142/356 (39%), Gaps = 56/356 (15%) Query: 20 VGPGVPGEVEMVKGQPFDV-GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEH 78 GP + E +K Q V + IG G +G V + + R A+K +S Sbjct: 512 QGPMLTHLEERIKMQDTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSI 571 Query: 79 QTYCQR--TLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKS 135 + Q+ E +I H +I + T + Y + +L+ +LY ++ Sbjct: 572 ISLNQQNNIKLEREITAENDHPFIIRLV-----RTFKDSNCFYFLTELVTGGELYDAIRK 626 Query: 136 -QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPE 194 LS ++L I+ ++Y+H N+++RDLKP N+L++ +K+ DFG A+ Sbjct: 627 LGLLSKPQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKI--- 683 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 G V T Y APE++L KGY ++DIW++G L E + F G DQL Sbjct: 684 ---QGRAYTLVGTPHYMAPEVILG-KGYGCTVDIWALGVCLYEFICGPLPF-GNDQEDQL 738 Query: 255 NHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFN 314 IL + P SD +++L+ R+L Sbjct: 739 EIFRDIL-----------------TGQLTFPDYV----------SDQDSINLMKRLLCRL 771 Query: 315 PNKRITV-----EEALAHPYLEQY-YDPTDEPVAEEPF-----TFAMELDDLPKER 359 P RI ++ H + + +D + E P T+A ++D E Sbjct: 772 PQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGETYAEDIDIKQIEE 827 >4B8L-A nrPDB Length = 286 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 64/296 (21%), Positives = 122/296 (41%), Gaps = 46/296 (15%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILLRFRH 97 + + +G+G +G V A + K +A+K + S E + + REI+I RH Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQ-QLSNDHICYFLYQILRGLK 155 N++ + + + +Y++ + +LYK L+ + F+ ++ L Sbjct: 75 PNILRMYNYFHDR-----KRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALH 129 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 Y H V+HRD+KP NLL+ +LKI DFG + H + T Y PE+ Sbjct: 130 YCHERKVIHRDIKPENLLMGYKGELKIADFGWSV-----HAPSLRRRTMCGTLDYLPPEM 184 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + K + + +D+W G + E L P F + + I+ + Sbjct: 185 IEG-KTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVD-------------- 229 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 K P + DL+ ++L ++P +R+ ++ + HP+++ Sbjct: 230 -----------------LKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVK 268 >4C0T-A nrPDB Length = 974 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 80/350 (22%), Positives = 148/350 (42%), Gaps = 48/350 (13%) Query: 24 VPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ 83 + GE++ ++ D + + +GEG+Y V A D + + A+K + + Sbjct: 254 MDGEMKTIRRNVTD----FKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKK 309 Query: 84 RTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKS-QQLSND 141 I+ R N + I T + +Y V D +L L+K L+ + Sbjct: 310 VKYVNIEKHALNRLSN--RLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEE 367 Query: 142 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTG-- 199 +F QIL +KY+H V+HRDLKP N+L++ ++I DFG AR+ + ++D + Sbjct: 368 CTRHFGAQILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEY 427 Query: 200 ----FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLN 255 +V T Y +PE++ N K K D+W+ GCI+ +M++ +P F + Sbjct: 428 PVDVRAKSFVGTAEYVSPELLEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQ 486 Query: 256 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 315 I +K + A++ FP DL+ ++L P Sbjct: 487 KI----------------------------TKLQFAFSAGFPTI---IRDLIKKILVLQP 515 Query: 316 NKRITVEEALAHPYLE--QYYDPTDEPVAEEPFTFAMELDDLPKERLKEL 363 ++R T+ E H + + + D +++ P ++ ++ EL Sbjct: 516 SRRATIPEIQKHYFFQSVDFKDFDSIWLSDPPEIGPYKMTAKSMMKVPEL 565 >4MD7-E nrPDB Length = 391 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 83/300 (27%), Positives = 148/300 (49%), Gaps = 21/300 (7%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-E 98 Y ++ +G G Y V A + + + ++ REI+IL R Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEK----VVVKILKPVKKKKIKREIKILENLRGGP 92 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 N+I + DI++ +V + + +K L Q L++ I +++Y+IL+ L Y H Sbjct: 93 NIITLADIVKDPVSRTPA---LVFEHVNNTDFKQL-YQTLTDYDIRFYMYEILKALDYCH 148 Query: 159 SANVLHRDLKPSNLLINTTCD-LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 S ++HRD+KP N++I+ L++ D+GLA P ++ VA+R+++ PE+++ Sbjct: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV----RVASRYFKGPELLV 204 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + + Y S+D+WS+GC+LA M+ + P F G DQL I +LG+ D N++ Sbjct: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 Query: 277 A-RNYLQSLPSKTKVAWAKLFPKS-----DSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + L ++ W + +ALD LD++L ++ R+T EA+ HPY Sbjct: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 >4APC-A nrPDB Length = 350 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 121/296 (40%), Gaps = 44/296 (14%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLR 94 F +Y +LQ IGEG++G + IK+I+ + + RE+ +L Sbjct: 20 FQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLAN 79 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ---LSNDHICYFLYQI 150 +H N++ R+ + +YIV D E DL+K + +Q+ D I + QI Sbjct: 80 MKHPNIVQYRESFEENGS-----LYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQI 134 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY 210 LK++H +LHRD+K N+ + +++ DFG+AR+ + + + T +Y Sbjct: 135 CLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVE---LARACIGTPYY 191 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 +PEI N K Y DIW++GC+L E+ + + F + + I+ P Sbjct: 192 LSPEICEN-KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPP------ 244 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 + L+ ++ NP R +V L Sbjct: 245 ------------------------VSLHYSYDLRSLVSQLFKRNPRDRPSVNSILE 276 >6CCF-A nrPDB Length = 290 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 75/321 (23%), Positives = 133/321 (41%), Gaps = 63/321 (19%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS------------------------- 74 +Y IG+GAYG+V AY+ A+K +S Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 75 PFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLL 133 P + +R +EI IL + H NV+ + ++L A ++Y+V DL+ + ++ Sbjct: 65 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDP---AEDNLYLVFDLLRKGPVMEVP 121 Query: 134 KSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADP 193 + S + +L ++ GL+Y+H ++HRD+KPSNLL+ +KI DFG++ + Sbjct: 122 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG 181 Query: 194 EHDHTGFLTEYVATRWYRAPEIM--LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 251 L+ T + APE + K++D+W+ G L + + F Sbjct: 182 NDAQ---LSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF------ 232 Query: 252 DQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRML 311 +D ++ K +N P + P+ + DL+ +ML Sbjct: 233 --------------IDDFILALHRKIKNEPVVFPEE---------PEISEELKDLILKML 269 Query: 312 TFNPNKRITVEEALAHPYLEQ 332 NP RI V + HP++ + Sbjct: 270 DKNPETRIGVPDIKLHPWVTK 290 >5LOH-A nrPDB Length = 341 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 71/364 (19%), Positives = 139/364 (38%), Gaps = 47/364 (12%) Query: 7 QGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKT 66 G + G G + +P + ++ ++ I GA+G V Sbjct: 4 MDPTAGSKKEPGGGAATEEGVNRIAVPKPPSI-EEFSIVKPISRGAFGKVYLGQ--KGGK 60 Query: 67 RVAIKKISPFE--HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDL 124 A+K + + ++ + E L + ++ + +L++ +VY+V + Sbjct: 61 LYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLY-----YSLQSANNVYLVMEY 115 Query: 125 M-ETDLYKLLK-SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKI 182 + D+ LL + ++ ++ L Y+H ++HRDLKP N+LI+ +K+ Sbjct: 116 LIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKL 175 Query: 183 CDFGLARI-ADPEHDHTGFLT--EYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239 DFGL+++ + + + LT + T Y APE++L + + ++D W++G L E L Sbjct: 176 TDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLG-RAHGPAVDWWALGVCLFEFL 234 Query: 240 SNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKS 299 + P F + +IL K + W + K Sbjct: 235 TGIPPFNDETPQQVFQNIL----------------------------KRDIPWPEGEEKL 266 Query: 300 DSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKER 359 A ++ +LT + KR ++E HP E + + F + DD Sbjct: 267 SDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDV---DWENLQHQTMPFIPQPDDETDTS 323 Query: 360 LKEL 363 E Sbjct: 324 YFEA 327 >3LM0-A nrPDB Length = 327 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 77/344 (22%), Positives = 142/344 (41%), Gaps = 51/344 (14%) Query: 22 PGVPGEVEMVKGQPFDVGPRYTQL--QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQ 79 GV E + Q + + L + +G G + +V A K + Sbjct: 9 SGVDLGTENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRG 68 Query: 80 TYCQ-RTLREIQILLRFRH-ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--- 134 C+ L EI +L + VI + ++ ++ + I++ +++ L Sbjct: 69 QDCRAEILHEIAVLELAKSCPRVINLHEVYENTS----EIILILEYAAGGEIFSLCLPEL 124 Query: 135 SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT---CDLKICDFGLARIA 191 ++ +S + + + QIL G+ Y+H N++H DLKP N+L+++ D+KI DFG++R Sbjct: 125 AEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKI 184 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 251 H L E + T Y APEI+ N T + D+W++G I +L++ F G+ Sbjct: 185 ----GHACELREIMGTPEYLAPEIL-NYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQ 239 Query: 252 DQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRML 311 + +I + S+E F A D + +L Sbjct: 240 ETYLNISQVNVDYSEET---------------------------FSSVSQLATDFIQSLL 272 Query: 312 TFNPNKRITVEEALAHPYLEQY-----YDPTDEPVAEEPFTFAM 350 NP KR T E L+H +L+Q+ + P + + + ++ Sbjct: 273 VKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSV 316 >2PVN-A nrPDB Length = 352 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 80/309 (25%), Positives = 150/309 (48%), Gaps = 21/309 (6%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 + Y ++ +G G Y V + K I ++ REI+IL Sbjct: 47 QWGEQDDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKKKKIKREIKILQN 102 Query: 95 F-RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 N++ + DI+R + ++ + + +K+L L++ I Y++Y++L+ Sbjct: 103 LCGGPNIVKLLDIVRDQHSKTPS---LIFEYVNNTDFKVL-YPTLTDYDIRYYIYELLKA 158 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCD-LKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 L Y HS ++HRD+KP N++I+ L++ D+GLA P ++ VA+R+++ Sbjct: 159 LDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNV----RVASRYFKG 214 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNC 271 PE++++ + Y S+D+WS+GC+ A M+ + P F G DQL I +LG+ Sbjct: 215 PELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLN 274 Query: 272 IINMKARNYLQSL-PSKTKVAWAKLF-----PKSDSKALDLLDRMLTFNPNKRITVEEAL 325 ++ L++L ++ W K +A+D LD++L ++ +R+T EA+ Sbjct: 275 KYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAM 334 Query: 326 AHPYLEQYY 334 HPY +Q Sbjct: 335 THPYFQQVR 343 >4XEY-B nrPDB Length = 408 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 65/316 (20%), Positives = 123/316 (38%), Gaps = 49/316 (15%) Query: 14 PRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI 73 P+R + GV + + + D+ T +G G YG V VA+K + Sbjct: 103 PKRNKPTVYGVSPNYDKWEMERTDI----TMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL 158 Query: 74 SPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKL 132 E + L+E ++ +H N++ + + YI+ + M +L Sbjct: 159 K--EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTRE-----PPFYIITEFMTYGNLLDY 211 Query: 133 LK---SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR 189 L+ Q+++ + Y QI ++Y+ N +HRDL N L+ +K+ DFGL+R Sbjct: 212 LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 271 Query: 190 IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGK 248 + + +T +W APE + +K ++ D+W+ G +L E+ + +PG Sbjct: 272 LMTGD-TYTAHAGAKFPIKW-TAPESLAYNK-FSIKSDVWAFGVLLWEIATYGMSPYPGI 328 Query: 249 HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLD 308 DL+ + + ++Y P K +L+ Sbjct: 329 -------------------DLSQVYELLEKDYRMERPE-----------GCPEKVYELMR 358 Query: 309 RMLTFNPNKRITVEEA 324 +NP+ R + E Sbjct: 359 ACWQWNPSDRPSFAEI 374 >6HMD-A nrPDB Length = 365 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 83/314 (26%), Positives = 154/314 (49%), Gaps = 21/314 (6%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-E 98 Y ++ +G G Y V A + R + ++ RE++IL R Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNER----VVVKILKPVKKKKIKREVKILENLRGGT 108 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 N+I + D ++ + +V + + +K L Q L++ I +++Y++L+ L Y H Sbjct: 109 NIIKLIDTVKDPVSKTPA---LVFEYINNTDFKQL-YQILTDFDIRFYMYELLKALDYCH 164 Query: 159 SANVLHRDLKPSNLLINT-TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 S ++HRD+KP N++I+ L++ D+GLA P ++ VA+R+++ PE+++ Sbjct: 165 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV----RVASRYFKGPELLV 220 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + + Y S+D+WS+GC+LA M+ R P F G+ DQL I +LG+ ++ Sbjct: 221 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 280 Query: 277 A-RNYLQSLPSKTKVAWAKLFPKS-----DSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 ++ L ++ W +ALDLLD++L ++ +R+T +EA+ HPY Sbjct: 281 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 340 Query: 331 EQYYDPTDEPVAEE 344 +P A+ Sbjct: 341 YPVVKEQSQPSADN 354 >2FO0-A nrPDB Length = 495 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 64/316 (20%), Positives = 123/316 (38%), Gaps = 49/316 (15%) Query: 14 PRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI 73 P+R + GV + + + D+ T +G G YG V VA+K + Sbjct: 195 PKRNKPTVYGVSPNYDKWEMERTDI----TMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL 250 Query: 74 SPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKL 132 E + L+E ++ +H N++ + + YI+ + M +L Sbjct: 251 K--EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTRE-----PPFYIITEFMTYGNLLDY 303 Query: 133 LK---SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR 189 L+ Q+++ + Y QI ++Y+ N +HR+L N L+ +K+ DFGL+R Sbjct: 304 LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSR 363 Query: 190 IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGK 248 + + +T +W APE + +K ++ D+W+ G +L E+ + +PG Sbjct: 364 LMTGD-TYTAHAGAKFPIKW-TAPESLAYNK-FSIKSDVWAFGVLLWEIATYGMSPYPGI 420 Query: 249 HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLD 308 DL+ + + ++Y P K +L+ Sbjct: 421 -------------------DLSQVYELLEKDYRMERPE-----------GCPEKVYELMR 450 Query: 309 RMLTFNPNKRITVEEA 324 +NP+ R + E Sbjct: 451 ACWQWNPSDRPSFAEI 466 >6EII-A nrPDB Length = 352 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 83/300 (27%), Positives = 148/300 (49%), Gaps = 21/300 (7%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-E 98 Y ++ +G G Y V A + + + ++ REI+IL R Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEK----VVVKILKPVKKKKIKREIKILENLRGGP 115 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 N+I + DI++ +V + + +K L Q L++ I +++Y+IL+ L Y H Sbjct: 116 NIITLADIVKDPVSRTPA---LVFEHVNNTDFKQL-YQTLTDYDIRFYMYEILKALDYCH 171 Query: 159 SANVLHRDLKPSNLLINTTCD-LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 S ++HRD+KP N++I+ L++ D+GLA P ++ VA+R+++ PE+++ Sbjct: 172 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV----RVASRYFKGPELLV 227 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + + Y S+D+WS+GC+LA M+ + P F G DQL I +LG+ D N++ Sbjct: 228 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 287 Query: 277 A-RNYLQSLPSKTKVAWAKLFPKS-----DSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + L ++ W + +ALD LD++L ++ R+T EA+ HPY Sbjct: 288 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >4GS6-A nrPDB Length = 315 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 85/355 (23%), Positives = 148/355 (41%), Gaps = 69/355 (19%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 + +G GA+G+V A + VAIK+I E ++ + + E++ L R H N++ Sbjct: 12 EVEEVVGRGAFGVVCKAKWRAKD--VAIKQI---ESESERKAFIVELRQLSRVNHPNIVK 66 Query: 103 IRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ----LSNDHICYFLYQILRGLKYI 157 + + V +V + E LY +L + + H + Q +G+ Y+ Sbjct: 67 LYGAC-------LNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYL 119 Query: 158 HSAN---VLHRDLKPSNLLINTTCDL-KICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 HS ++HRDLKP NLL+ + KICDFG A D +T + + AP Sbjct: 120 HSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC------DIQTHMTNNKGSAAWMAP 173 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 E+ S Y++ D++S G IL E+++ R F +G P+ + + Sbjct: 174 EVFEGS-NYSEKCDVFSWGIILWEVITRRKPF-------------DEIGGPAFRIMWAVH 219 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEE---ALAHPYL 330 N +++LP + L+ R + +P++R ++EE + H L Sbjct: 220 NGTRPPLIKNLPKPIE---------------SLMTRCWSKDPSQRPSMEEIVKIMTH--L 262 Query: 331 EQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARF------QPGVLEAP 379 +Y+ DEP+ +D E + F E R + V+ AP Sbjct: 263 MRYFPGADEPLQYPCQHSLPPGEDGRVEPY--VDFAEFYRLWSVDHGEQSVVTAP 315 >2H8H-A nrPDB Length = 535 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 76/329 (23%), Positives = 137/329 (41%), Gaps = 51/329 (15%) Query: 22 PGVPGEVEMVKGQPFDVGPRYTQLQY-IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQT 80 P + + + +++ +L+ +G+G +G V + TRVAIK + P Sbjct: 248 PTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS- 305 Query: 81 YCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ-- 137 + L+E Q++ + RHE ++ + ++ + +YIV + M L LK + Sbjct: 306 -PEAFLQEAQVMKKLRHEKLVQLYAVV------SEEPIYIVTEYMSKGSLLDFLKGETGK 358 Query: 138 -LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 L + QI G+ Y+ N +HRDL+ +N+L+ K+ DFGLAR+ + +++ Sbjct: 359 YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNE 417 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLN 255 +T +W APE L + +T D+WS G +L E+ + R +PG + L+ Sbjct: 418 YTARQGAKFPIKW-TAPEAALYGR-FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD 475 Query: 256 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 315 + P P+ DL+ + P Sbjct: 476 QVERGYRMPCP------------------------------PECPESLHDLMCQCWRKEP 505 Query: 316 NKRITVEEALAHPYLEQYYDPTDEPVAEE 344 +R T E A +LE Y+ + EP + Sbjct: 506 EERPTFEYLQA--FLEDYFT-STEPQYQP 531 >6F3F-A nrPDB Length = 455 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 76/329 (23%), Positives = 137/329 (41%), Gaps = 51/329 (15%) Query: 22 PGVPGEVEMVKGQPFDVGPRYTQLQY-IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQT 80 P + + + +++ +L+ +G+G +G V + TRVAIK + P Sbjct: 168 PTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS- 225 Query: 81 YCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ-- 137 + L+E Q++ + RHE ++ + ++ + +YIV + M L LK + Sbjct: 226 -PEAFLQEAQVMKKLRHEKLVQLYAVV------SEEPIYIVTEYMNKGSLLDFLKGETGK 278 Query: 138 -LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 L + QI G+ Y+ N +HRDL+ +N+L+ K+ DFGLAR+ + +++ Sbjct: 279 YLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNE 337 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLN 255 +T +W APE L + +T D+WS G +L E+ + R +PG + L+ Sbjct: 338 YTARQGAKFPIKW-TAPEAALYGR-FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD 395 Query: 256 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 315 + P P+ DL+ + P Sbjct: 396 QVERGYRMPCP------------------------------PECPESLHDLMCQCWRKEP 425 Query: 316 NKRITVEEALAHPYLEQYYDPTDEPVAEE 344 +R T E A +LE Y+ + EP + Sbjct: 426 EERPTFEYLQA--FLEDYFT-STEPQYQP 451 >3A8W-A nrPDB Length = 345 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 66/344 (19%), Positives = 135/344 (39%), Gaps = 42/344 (12%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF--EHQTYCQRTLREIQILLRF-RHE 98 + L+ IG G+Y V A+K + E + + H Sbjct: 11 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP 70 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDL-YKLLKSQQLSNDHICYFLYQILRGLKYI 157 ++G+ + + R ++++ + DL + + + ++L +H ++ +I L Y+ Sbjct: 71 FLVGLHSCFQTES----RLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYL 126 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 H +++RDLK N+L+++ +K+ D+G+ + D T + T Y APEI+ Sbjct: 127 HERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTS---TFCGTPNYIAPEILR 183 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 + Y S+D W++G ++ EM++ R F I+GS D N Sbjct: 184 G-EDYGFSVDWWALGVLMFEMMAGRSPF-------------DIVGSSDNPDQNT------ 223 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV------EEALAHPYLE 331 +YL + + ++ + KA +L L +P +R+ + HP+ Sbjct: 224 EDYLFQVILEKQIRIPR---SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFR 280 Query: 332 QY-YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPG 374 +D ++ PF + + + E + P Sbjct: 281 NVDWDMMEQKQVVPPFKPNIS-GEFGLDNFDSQFTNEPVQLTPD 323 >6DBM-A nrPDB Length = 318 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 120/298 (40%), Gaps = 25/298 (8%) Query: 33 GQPFDVGPRY-TQLQYIGEGAYGMVSS-AYDHV---RKTRVAIKKISPFEHQTYCQRTLR 87 G P RY +++ +GEG +G VS YD VA+K + + + Sbjct: 23 GDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQ 82 Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSNDHICYF 146 EI IL HE++I + + +++ +V + + L L + + F Sbjct: 83 EIDILRTLYHEHIIKYKGCCEDAGAASLQ---LVMEYVPLGSLRDYLPRHSIGLAQLLLF 139 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 QI G+ Y+HS + +HRDL N+L++ +KI DFGLA+ H++ + + Sbjct: 140 AQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDS 199 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 ++ APE + K Y + D+WS G L E+L+ L ++G +Q Sbjct: 200 PVFWYAPECLKEYKFY-YASDVWSFGVTLYELLT-----HCDSSQSPPTKFLELIG-IAQ 252 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 + + + + LP K ++ L+ + R T E Sbjct: 253 GQMTVLRLTELLERGERLPRPDKCP---------AEVYHLMKNCWETEASFRPTFENL 301 >4OLI-A nrPDB Length = 645 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 117/297 (39%), Gaps = 25/297 (8%) Query: 34 QPFDVGPRY-TQLQYIGEGAYGMVSS-AYDHV---RKTRVAIKKISPFEHQTYCQRTLRE 88 P RY +++ +GEG +G VS YD VA+K + + +E Sbjct: 346 DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQE 405 Query: 89 IQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSNDHICYFL 147 I IL HE++I + + + + +V + + L L + + F Sbjct: 406 IDILRTLYHEHIIKYKGCCED---QGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFA 462 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 QI G+ Y+HS + +HR+L N+L++ +KI DFGLA+ H++ + + Sbjct: 463 QQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP 522 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 ++ APE + K Y + D+WS G L E+L+ L ++G +Q Sbjct: 523 VFWYAPECLKEYKFY-YASDVWSFGVTLYELLT-----HCDSSQSPPTKFLELIG-IAQG 575 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 + + + + LP K + L+ + R T E Sbjct: 576 QMTVLRLTELLERGERLPRPDKCP---------CEVYHLMKNCWETEASFRPTFENL 623 Score = 93.9 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 38/279 (13%), Positives = 87/279 (31%), Gaps = 55/279 (19%) Query: 59 AYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDV 118 D ++ RV +K + P H ++ + H ++ + + + ++ Sbjct: 88 GRDRGQELRVVLKVLDP-SHHDIALAFYETASLMSQVSHTHLAFVHGVC----VRGPENI 142 Query: 119 YIVQDLMETDLYKLLKSQQ--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLI-- 174 + + + L L+ ++ + Q+ L Y+ + N++H ++ N+L+ Sbjct: 143 MVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLAR 202 Query: 175 -----NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS-KGYTKSIDI 228 T+ +K+ D G+ A + + + APE + + ++D Sbjct: 203 LGLAEGTSPFIKLSDPGVGLGALSREERVERI-------PWLAPECLPGGANSLSTAMDK 255 Query: 229 WSVGCILAEM-LSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSK 287 W G L E+ + + LP Sbjct: 256 WGFGATLLEICFDGEAPLQSRSPSE---------------------KEHFYQRQHRLPEP 294 Query: 288 TKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 + A L + LT+ P +R + L Sbjct: 295 SCPQLAT-----------LTSQCLTYEPTQRPSFRTILR 322 >4AF3-A nrPDB Length = 292 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 124/312 (39%), Gaps = 47/312 (15%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQIL 92 F + + + +G+G +G V A + VA+K + S E + + REI+I Sbjct: 19 HFTIDD-FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 77 Query: 93 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYK-LLKSQQLSNDHICYFLYQI 150 H N++ + + R +Y++ + +LYK L KS + ++ Sbjct: 78 AHLHHPNILRLYNYFYDR-----RRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEEL 132 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY 210 L Y H V+HRD+KP NLL+ +LKI DFG + H + T Y Sbjct: 133 ADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV-----HAPSLRRKTMCGTLDY 187 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 PE++ + + + +D+W +G + E+L P F + + I+ + Sbjct: 188 LPPEMIEG-RMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVD--------- 237 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 K + A DL+ ++L NP++R+ + + AHP++ Sbjct: 238 ----------------------LKFPASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWV 275 Query: 331 EQYYDPTDEPVA 342 P A Sbjct: 276 RANSRRVLPPSA 287 >3RAW-A nrPDB Length = 381 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 84/331 (25%), Positives = 132/331 (39%), Gaps = 52/331 (15%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKT-RVAIKKISPFEHQTYCQRTLREIQILLRFR-- 96 RY + +GEG +G V DH R +VA+K I Y + EI +L + + Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVG--KYREAARLEINVLKKIKEK 108 Query: 97 -HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQL---SNDHICYFLYQILR 152 EN +L + + I +L+ + ++ LK H+ + YQ+ Sbjct: 109 DKEN--KFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCH 166 Query: 153 GLKYIHSANVLHRDLKPSNLLINT-------------------TCDLKICDFGLARIADP 193 L+++H + H DLKP N+L +++ DFG A Sbjct: 167 ALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHE 226 Query: 194 EHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQ 253 H T VATR YR PE++L G+ + D+WS+GCIL E +F + Sbjct: 227 HH------TTIVATRHYRPPEVILE-LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREH 279 Query: 254 LNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPK--------------S 299 L + ILG P + + Y L + + + Sbjct: 280 LVMMEKILG-PIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLE 338 Query: 300 DSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + DL+ RML F+P +RIT+ EAL HP+ Sbjct: 339 HVQLFDLMRRMLEFDPAQRITLAEALLHPFF 369 >5MJB-A nrPDB Length = 305 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 69/285 (24%), Positives = 118/285 (41%), Gaps = 27/285 (9%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTR---VAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 + IG G +G V + R VAIK + + + L E I+ +F H N Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRN 88 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILRGLKY 156 +I + ++ S R V I+ + ME D + Q + + L I G+KY Sbjct: 89 IIRLEGVVTKS-----RPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKY 143 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD---HTGFLTEYVATRWYRAP 213 + N +HRDL N+L+N+ K+ DFGL+R + +T L + RW AP Sbjct: 144 LSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW-TAP 202 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 E + + +T + D+WS G ++ E++S + D +N I P D Sbjct: 203 EAIA-YRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAA 261 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNK 317 ++ + Q + ++ ++ LD+M+ NP Sbjct: 262 LHQLMLDCWQKDRNSRPRF---------AEIVNTLDKMI-RNPAS 296 >4RA4-A nrPDB Length = 355 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 60/321 (18%), Positives = 126/321 (39%), Gaps = 51/321 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFRHE- 98 + L +G+G++G V A + AIK + + T+ E ++L Sbjct: 22 FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP 81 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGLKY 156 + + S + + +Y V + + +Y + + + ++ +I GL + Sbjct: 82 FLTQLH-----SCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFF 136 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 +H +++RDLK N+++++ +KI DFG+ + + T + T Y APEI+ Sbjct: 137 LHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTT---RTFCGTPDYIAPEII 193 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + Y KS+D W+ G +L EML+ +P F G+ + I+ S + Sbjct: 194 A-YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPK---------- 242 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV-----EEALAHPYLE 331 +A+ + ++T +P KR+ + H + Sbjct: 243 ---------------------SLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFR 281 Query: 332 Q-YYDPTDEPVAEEPFTFAME 351 + ++ + + PF + Sbjct: 282 RIDWEKLENREIQPPFKPKVS 302 >4AW2-A nrPDB Length = 437 Score = 211 bits (538), Expect = 4e-55, Method: Composition-based stats. Identities = 64/350 (18%), Positives = 127/350 (36%), Gaps = 48/350 (13%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQR--TLREIQILLRFRHEN 99 + L+ IG GA+G V+ A+K ++ +E + E +L+ + Sbjct: 76 FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKW 135 Query: 100 VIGIRDILRASTLEAMRDVYIVQ-DLMETDLYKLLKS--QQLSNDHICYFLYQILRGLKY 156 + + + ++Y+V + DL LL +L + ++L +++ + Sbjct: 136 ITTLH-----YAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDS 190 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 +H + +HRD+KP N+L++ +++ DFG D T + V T Y +PEI+ Sbjct: 191 VHQLHYVHRDIKPDNILMDMNGHIRLADFGSC--LKLMEDGTVQSSVAVGTPDYISPEIL 248 Query: 217 L----NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 Y D WS+G + EML F + ++ I+ Sbjct: 249 QAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN------------- 295 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI---TVEEALAHPY 329 K + + A DL+ R++ + R+ +E+ HP+ Sbjct: 296 -------------HKERFQFPTQVTDVSENAKDLIRRLIC-SREHRLGQNGIEDFKKHPF 341 Query: 330 LEQYYDPTDEPVAEEPFTFAMEL-DDLPKERLKELIFQETARFQPGVLEA 378 D + E P+ + D + + + + P A Sbjct: 342 FS-GIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTA 390 >6E2O-A nrPDB Length = 295 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 77/291 (26%), Positives = 128/291 (43%), Gaps = 42/291 (14%) Query: 47 YIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDI 106 +G+G YG+V + D + R+AIK+I P Y Q EI + +H+N++ Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEI-PERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 87 Query: 107 LRASTLEAMRDVYIVQDLMETDLYKLLKSQ----QLSNDHICYFLYQILRGLKYIHSANV 162 + + ++ + L LL+S+ + + I ++ QIL GLKY+H + Sbjct: 88 FSENGFIKI----FMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQI 143 Query: 163 LHRDLKPSNLLINT-TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS-K 220 +HRD+K N+LINT + LKI DFG ++ + T T T Y APEI+ + Sbjct: 144 VHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT---GTLQYMAPEIIDKGPR 200 Query: 221 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNY 280 GY K+ DIWS+GC + EM + +P F LG P + + Sbjct: 201 GYGKAADIWSLGCTIIEMATGKPPFYE-------------LGEP----QAAMFKVGMFKV 243 Query: 281 LQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 +P ++A + + +P+KR + L +L+ Sbjct: 244 HPEIPE-----------SMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >4E20-A nrPDB Length = 290 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 63/297 (21%), Positives = 115/297 (38%), Gaps = 25/297 (8%) Query: 34 QPFDVGPRY-TQLQYIGEGAYGMVSS-AYDHV---RKTRVAIKKISPFEHQTYCQRTLRE 88 P RY +++ +GEG +G VS YD VA+K + RE Sbjct: 1 DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQRE 60 Query: 89 IQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSNDHICYFL 147 I+IL HE+++ + + + V +V + + L L + + F Sbjct: 61 IEILRTLYHEHIVKYKGCCED---QGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFA 117 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 QI G+ Y+H+ + +HR L N+L++ +KI DFGLA+ H++ + + Sbjct: 118 QQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP 177 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 ++ APE + K Y + D+WS G L E+L+ ++G +Q Sbjct: 178 VFWYAPECLKECKFY-YASDVWSFGVTLYELLT-----YCDSNQSPHTKFTELIGH-TQG 230 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 + + + + LP + + L+ + R T + Sbjct: 231 QMTVLRLTELLERGERLPRPDRCP---------CEIYHLMKNCWETEASFRPTFQNL 278 >4FR4-A nrPDB Length = 384 Score = 210 bits (535), Expect = 9e-55, Method: Composition-based stats. Identities = 72/318 (22%), Positives = 139/318 (43%), Gaps = 50/318 (15%) Query: 22 PGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQ 79 P V E E V F++ L+ IG+G++G V + K A+K ++ + + Sbjct: 3 PPVFDENEDVNFDHFEI------LRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVER 56 Query: 80 TYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDL-YKLLKSQQ 137 + +E+QI+ H ++ + + + D+++V DL+ DL Y L ++ Sbjct: 57 NEVRNVFKELQIMQGLEHPFLVNL-----WYSFQDEEDMFMVVDLLLGGDLRYHLQQNVH 111 Query: 138 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDH 197 + + F+ +++ L Y+ + ++HRD+KP N+L++ + I DF +A + E Sbjct: 112 FKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRE--- 168 Query: 198 TGFLTEYVATRWYRAPEIMLNSK--GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLN 255 +T T+ Y APE+ + K GY+ ++D WS+G E+L R + Sbjct: 169 -TQITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYH--------- 218 Query: 256 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 315 I S S +++ Y AW + + LL ++L NP Sbjct: 219 ----IRSSTSSKEIVHTFETTVVTY--------PSAW-------SQEMVSLLKKLLEPNP 259 Query: 316 NKRIT-VEEALAHPYLEQ 332 ++R + + + PY+ Sbjct: 260 DQRFSQLSDVQNFPYMND 277 >6BSD-A nrPDB Length = 876 Score = 210 bits (535), Expect = 9e-55, Method: Composition-based stats. Identities = 75/367 (20%), Positives = 130/367 (35%), Gaps = 78/367 (21%) Query: 7 QGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQ--LQYIGEGAYGMVSSAY---- 60 QG GG + PG G+ G P PR + +GEG +G V Sbjct: 541 QGVTGGNTYAVPALPPGAVGD-----GPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSP 595 Query: 61 ----------DHVRKTR--VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILR 108 + + VA+K + P + L+E++I+ R + N+I + + Sbjct: 596 QDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCV 655 Query: 109 ASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSN--------------------DHICYFL 147 + ++ D ME DL + L + QL + + + Sbjct: 656 QDD-----PLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVA 710 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 QI G++Y+ + N +HRDL N L+ +KI DFG++R + + Sbjct: 711 AQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPI 770 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAE--MLSNRPIFPGKHYLDQLNHILGILGSPS 265 RW A E +L K +T + D+W+ G L E ML F G + Sbjct: 771 RW-MAWECILMGK-FTTASDVWAFGVTLWEVLMLCRAQPF----------------GQLT 812 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 E + N + + + + P +L+ R + +R + Sbjct: 813 DEQV-------IENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL- 864 Query: 326 AHPYLEQ 332 H +L + Sbjct: 865 -HRFLAE 870 >6DBN-A nrPDB Length = 316 Score = 210 bits (534), Expect = 9e-55, Method: Composition-based stats. Identities = 65/317 (20%), Positives = 129/317 (40%), Gaps = 26/317 (8%) Query: 18 EGVGPGVPGEVEM-VKGQPFDVGPRY-TQLQYIGEGAYGMVSSAY----DHVRKTRVAIK 71 E P + E + + P R+ +++ +GEG +G V +VA+K Sbjct: 11 EEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVK 70 Query: 72 KISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYK 131 + P + +EI+IL HEN++ + I ++ I++ L L + Sbjct: 71 SLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIK--LIMEFLPSGSLKE 128 Query: 132 LL--KSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR 189 L +++ + QI +G+ Y+ S +HRDL N+L+ + +KI DFGL + Sbjct: 129 YLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTK 188 Query: 190 IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKH 249 + + ++ + + ++ APE ++ SK Y + D+WS G L E+L+ Sbjct: 189 AIETDKEYYTVKDDRDSPVFWYAPECLMQSKFY-IASDVWSFGVTLHELLT-----YCDS 242 Query: 250 YLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDR 309 + L ++G M + +L ++ P + L+ + Sbjct: 243 DSSPMALFLKMIG-------PTHGQMTVTRLVNTLKEGKRLPCP---PNCPDEVYQLMRK 292 Query: 310 MLTFNPNKRITVEEALA 326 F P+ R + + + Sbjct: 293 CWEFQPSNRTSFQNLIE 309 >5L6P-A nrPDB Length = 298 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 69/285 (24%), Positives = 117/285 (41%), Gaps = 27/285 (9%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTR---VAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 + IG G +G V R VAIK + + + L E I+ +F H N Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPN 81 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILRGLKY 156 +I + ++ S R V I+ + ME D + L Q + + L I G+KY Sbjct: 82 IIRLEGVVTKS-----RPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKY 136 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD---HTGFLTEYVATRWYRAP 213 + N +HRDL N+L+N+ K+ DFGL+R + + +T L + RW AP Sbjct: 137 LSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRW-TAP 195 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 E + + +T + D+WS G ++ E++S + D +N + P D Sbjct: 196 EAIA-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTA 254 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNK 317 ++ + + S+ ++ LD+ L NP Sbjct: 255 LHQLMLDCWVRDRNLRPKF---------SQIVNTLDK-LIRNPAS 289 >3TKU-A nrPDB Length = 433 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 57/302 (18%), Positives = 116/302 (38%), Gaps = 46/302 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQR--TLREIQILLRFRHEN 99 + ++ IG GA+G V+ + A+K ++ +E + E +L+ + Sbjct: 92 FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW 151 Query: 100 VIGIRDILRASTLEAMRDVYIVQ-DLMETDLYKLLKS--QQLSNDHICYFLYQILRGLKY 156 + + + +Y+V + DL LL +L D +++ +++ + Sbjct: 152 ITALH-----YAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDS 206 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 IH + +HRD+KP N+L++ +++ DFG D T + V T Y +PEI+ Sbjct: 207 IHQLHYVHRDIKPDNVLLDVNGHIRLADFGSC--LKMNDDGTVQSSVAVGTPDYISPEIL 264 Query: 217 L----NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 Y D WS+G + EML F + ++ I+ Sbjct: 265 QAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN------------- 311 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI---TVEEALAHPY 329 + + + +A DL+ R++ + +R+ +E+ H + Sbjct: 312 -------------HEERFQFPSHVTDVSEEAKDLIQRLIC-SRERRLGQNGIEDFKKHAF 357 Query: 330 LE 331 E Sbjct: 358 FE 359 >5TQX-A nrPDB Length = 655 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 72/293 (24%), Positives = 117/293 (39%), Gaps = 20/293 (6%) Query: 34 QPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILL 93 F G + + +G G +G V ++AIK +R EIQI+ Sbjct: 2 PEFGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMK 61 Query: 94 RFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ----LSNDHICYFLY 148 + H NV+ D+ + + + DL KLL + L I L Sbjct: 62 KLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLS 121 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLI-NTTCDL--KICDFGLARIADPEHDHTGFLTEYV 205 I G++Y+H ++HRDLKP N+++ + + KI D G A+ + D TE+V Sbjct: 122 DIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAK----DVDQGELCTEFV 177 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 T Y APE + +K YT ++D WS G ++ E ++ F H+L I Sbjct: 178 GTLQYLAPE-LFENKPYTATVDYWSFGTMVFECIAGYRPF--LHHLQPFTWHEKIKKKDP 234 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKR 318 + C + LP + + P + L ML ++P +R Sbjct: 235 KCIFACEEMSGEVRFSSHLPQPNSLCSLIVEPMENW-----LQLMLNWDPQQR 282 >6GQK-A nrPDB Length = 328 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 122/311 (39%), Gaps = 59/311 (18%) Query: 40 PRYTQLQYIGEGAYGMVSSA-----YDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 R + + +G GA+G V A VA+K + P H T + + E+++L Sbjct: 41 NRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSY 100 Query: 95 F-RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ---------------- 137 HEN++ + + I + DL L+ ++ Sbjct: 101 LGNHENIVNLLGACT----HGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKD 156 Query: 138 -LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 L+ +H+ F YQ+ +G+ ++ S N +HRDL N+L+ KICDFGLAR + + Sbjct: 157 FLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSN 216 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLN 255 + + +W APE + NS YT D+WS G L E+ S +PG + Sbjct: 217 YVDKGNARLPVKW-MAPESIFNS-VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY 274 Query: 256 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 315 ++ + S P + ++ D++ +P Sbjct: 275 KMIK------------------EGFRMSSPEY-----------APAEMYDIMKTCWDADP 305 Query: 316 NKRITVEEALA 326 +KR T ++ + Sbjct: 306 DKRPTFKQIVQ 316 >5A46-A nrPDB Length = 386 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 65/308 (21%), Positives = 126/308 (40%), Gaps = 36/308 (11%) Query: 14 PRRTEGVGPGV---PGEVEMVKGQPFDVG-PRYTQLQYIGEGAYGMVSSA------YDHV 63 P R G + E E+ + +++ R + +GEG +G V A D Sbjct: 10 PSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKP 69 Query: 64 RK-TRVAIKKISPFEHQTYCQRTLREIQILLRF-RHENVIGIRDILRASTLEAMRDVYIV 121 + T+VA+K + + + E++++ +H+N+I + + IV Sbjct: 70 NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT----QDGPLYVIV 125 Query: 122 QDLMETDLYKLLKSQQ-----------------LSNDHICYFLYQILRGLKYIHSANVLH 164 + + +L + L++++ LS+ + YQ+ RG++Y+ S +H Sbjct: 126 EYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIH 185 Query: 165 RDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTK 224 RDL N+L+ +KI DFGLAR + + +W APE + + + YT Sbjct: 186 RDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKW-MAPEALFD-RIYTH 243 Query: 225 SIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQS 283 D+WS G +L E+ + +PG + + + + M R+ + Sbjct: 244 QSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHA 303 Query: 284 LPSKTKVA 291 +PS+ Sbjct: 304 VPSQRPTF 311 >5SYS-A nrPDB Length = 286 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 74/322 (22%), Positives = 135/322 (41%), Gaps = 51/322 (15%) Query: 29 EMVKGQPFDVGPRYTQLQY-IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR 87 + + +++ +L+ +G+G +G + TRVAIK + P + L+ Sbjct: 6 QGLAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGT-TRVAIKTLKPGTMS--PEAFLQ 62 Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKS---QQLSNDHI 143 E Q++ + RHE ++ + ++ + +YIV + M L LK + L + Sbjct: 63 EAQVMKKLRHEKLVQLYAVV------SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQL 116 Query: 144 CYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE 203 QI G+ Y+ N +HRDL+ +N+L+ K+ DFGLAR+ + ++++T Sbjct: 117 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGA 175 Query: 204 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILG 262 +W APE L + +T D+WS G +L E+ + R +PG + L+ + Sbjct: 176 KFPIKW-TAPEAALYGR-FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 233 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVE 322 P P+ DL+ + +P +R T E Sbjct: 234 MPCP------------------------------PECPESLHDLMCQCWRKDPEERPTFE 263 Query: 323 EALAHPYLEQYYDPTDEPVAEE 344 A +LE Y+ + EP + Sbjct: 264 YLQA--FLEDYFT-STEPQYQP 282 >1JPA-A nrPDB Length = 312 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 74/285 (25%), Positives = 122/285 (42%), Gaps = 27/285 (9%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTR---VAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 Q IG G +G V S + + R VAIK + + + L E I+ +F H N Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPN 95 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLK--SQQLSNDHICYFLYQILRGLKY 156 VI + ++ ST V I+ + ME L L+ Q + + L I G+KY Sbjct: 96 VIHLEGVVTKST-----PVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKY 150 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD---HTGFLTEYVATRWYRAP 213 + N +HRDL N+L+N+ K+ DFGL+R + + +T L + RW AP Sbjct: 151 LADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW-TAP 209 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 E + + +T + D+WS G ++ E++S + D +N I P D Sbjct: 210 EAI-QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSA 268 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNK 317 ++ + Q + + ++ LD+M+ NPN Sbjct: 269 LHQLMLDCWQKDRNHRPKF---------GQIVNTLDKMI-RNPNS 303 >2WQN-A nrPDB Length = 310 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 75/313 (23%), Positives = 129/313 (41%), Gaps = 47/313 (15%) Query: 20 VGPGVPGEVEMVKGQP---FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF 76 GP VP +P ++ + + IG G + V A + VA+KK+ F Sbjct: 9 QGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIF 68 Query: 77 EHQTYCQRT--LREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLL 133 + R ++EI +L + H NVI + ++ IV +L + DL +++ Sbjct: 69 DLMDAKARADCIKEIDLLKQLNHPNVIKYYA-----SFIEDNELNIVLELADAGDLSRMI 123 Query: 134 K-----SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLA 188 K + + + + Q+ L+++HS V+HRD+KP+N+ I T +K+ D GL Sbjct: 124 KHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLG 183 Query: 189 RIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 248 R + T V T +Y +PE + + GY DIWS+GC+L EM + + F G Sbjct: 184 RFFSSK---TTAAHSLVGTPYYMSPERI-HENGYNFKSDIWSLGCLLYEMAALQSPFYGD 239 Query: 249 HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLD 308 + +L + + LPS + L++ Sbjct: 240 -----------------KMNLYSLCKKIEQCDYPPLPSD----------HYSEELRQLVN 272 Query: 309 RMLTFNPNKRITV 321 + +P KR V Sbjct: 273 MCINPDPEKRPDV 285 >2VWV-A nrPDB Length = 302 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 72/303 (23%), Positives = 124/303 (40%), Gaps = 28/303 (9%) Query: 26 GEVEMVKGQPFDVGPRYTQLQ-YIGEGAYGMVSSAYDHVRKTR---VAIKKISPFEHQTY 81 E V+ ++ Y +++ IG G +G V + VAIK + + Sbjct: 1 DPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQ 60 Query: 82 CQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQL 138 + L E I+ +F H N+I + ++ S V I+ + ME D + L Q Sbjct: 61 RREFLSEASIMGQFEHPNIIRLEGVVTNS-----MPVMILTEFMENGALDSFLRLNDGQF 115 Query: 139 SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIAD---PEH 195 + + L I G++Y+ + +HRDL N+L+N+ K+ DFGL+R + + Sbjct: 116 TVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDP 175 Query: 196 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQL 254 T L + RW APE + + +T + D WS G ++ E++S + D + Sbjct: 176 TETSSLGGKIPIRW-TAPEAIA-FRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVI 233 Query: 255 NHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFN 314 N I P D ++ + Q + FP+ S LD+M+ N Sbjct: 234 NAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPR-----FPQVVSA----LDKMI-RN 283 Query: 315 PNK 317 P Sbjct: 284 PAS 286 >3TT0-A nrPDB Length = 382 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 123/294 (41%), Gaps = 33/294 (11%) Query: 25 PGEVEMVKGQPFDVG-PRYTQLQYIGEGAYGMVSSA------YDHVRK-TRVAIKKISPF 76 E E+ + +++ R + +GEGA+G V A D + T+VA+K + Sbjct: 53 VSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD 112 Query: 77 EHQTYCQRTLREIQILLRF-RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS 135 + + E++++ +H+N+I + + IV+ + +L + L++ Sbjct: 113 ATEKDLSDLISEMEMMKMIGKHKNIINLLGACT----QDGPLYVIVEYASKGNLREYLQA 168 Query: 136 QQ-----------------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC 178 ++ LS+ + YQ+ RG++Y+ S +HRDL N+L+ Sbjct: 169 RRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN 228 Query: 179 DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM 238 +KI DFGLAR + + +W APE + + + YT D+WS G +L E+ Sbjct: 229 VMKIADFGLARDIHHIDYYKKTTNGRLPVKW-MAPEALFD-RIYTHQSDVWSFGVLLWEI 286 Query: 239 LS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVA 291 + +PG + + + + M R+ ++PS+ Sbjct: 287 FTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF 340 >3ALO-A nrPDB Length = 327 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 72/331 (21%), Positives = 135/331 (40%), Gaps = 48/331 (14%) Query: 25 PGEVEMVKGQPFDVG-PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ 83 G++++ Q +D L IG GAYG V+ +A+K+I + + Sbjct: 6 SGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQK 65 Query: 84 RTLREIQI-LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK------SQ 136 + L ++ + + ++ L D +I +LM T K K Sbjct: 66 QLLMDLDVVMRSSDCPYIVQFYGALFREG-----DCWICMELMSTSFDKFYKYVYSVLDD 120 Query: 137 QLSNDHICYFLYQILRGLKYIHSA-NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH 195 + + + ++ L ++ ++HRD+KPSN+L++ + ++K+CDFG++ Sbjct: 121 VIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVD-- 178 Query: 196 DHTGFLTEYVATRWYRAPEIM---LNSKGYTKSIDIWSVGCILAEMLSNRPIFPG-KHYL 251 + T R Y APE + + +GY D+WS+G L E+ + R +P Sbjct: 179 --SIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVF 236 Query: 252 DQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRML 311 DQL ++ G P Q + N + R + S ++ ++ L Sbjct: 237 DQLTQVVK--GDPPQ-----LSNSEEREFSPSF-------------------INFVNLCL 270 Query: 312 TFNPNKRITVEEALAHPYLEQYYDPTDEPVA 342 T + +KR +E L HP++ Y + E Sbjct: 271 TKDESKRPKYKELLKHPFILMYEERAVEVAC 301 >4EBW-A nrPDB Length = 304 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 59/292 (20%), Positives = 112/292 (38%), Gaps = 46/292 (15%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTR---VAIKKISPFEHQTYCQRTLREIQILLRFR 96 R + IGEG +G V + VAIK + ++ L+E + +F Sbjct: 38 ERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFD 97 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSNDHI--CYFLYQILRG 153 H +++ + ++ V+I+ +L +L L+ ++ S D + YQ+ Sbjct: 98 HPHIVKLIGVITE------NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTA 151 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 L Y+ S +HRD+ N+L+++ +K+ DFGL+R + + + + +W AP Sbjct: 152 LAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKASKGKLPIKW-MAP 209 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 E + N + +T + D+W G + E+L F G D + I P Sbjct: 210 ESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP------ 262 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 P L+ + ++P++R E Sbjct: 263 ------------------------PNCPPTLYSLMTKCWAYDPSRRPRFTEL 290 >1TKI-A nrPDB Length = 321 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 135/310 (43%), Gaps = 44/310 (14%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 ++ +Y + +G G +G+V + K K + +EI IL R Sbjct: 2 ELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVL--VKKEISILNIAR 59 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ--QLSNDHICYFLYQILRG 153 H N++ + + + E+M ++ ++ + + D+++ + + +L+ I +++Q+ Sbjct: 60 HRNILHLHE-----SFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEA 114 Query: 154 LKYIHSANVLHRDLKPSNLLINT--TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 L+++HS N+ H D++P N++ T + +KI +FG AR P + T Y Sbjct: 115 LQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTA----PEYY 170 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 APE+ + + + D+WS+G ++ +LS F + + +I+ + +E Sbjct: 171 APEVHQHDVV-STATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEE---- 225 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 F + +A+D +DR+L R+T EAL HP+L+ Sbjct: 226 -----------------------AFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLK 262 Query: 332 QYYDPTDEPV 341 Q + V Sbjct: 263 QKIERVSTKV 272 >4KIK-B nrPDB Length = 677 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 71/288 (24%), Positives = 113/288 (39%), Gaps = 21/288 (7%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + + +G G +G V ++ ++AIK+ +R EIQI+ R H NV+ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 80 Query: 102 GIRDILRASTLEAMRDV-YIVQDLM-ETDLYKLLKSQQ----LSNDHICYFLYQILRGLK 155 RD+ A D+ + + DL K L + L I L I L+ Sbjct: 81 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 140 Query: 156 YIHSANVLHRDLKPSNLLINTTCDL---KICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 Y+H ++HRDLKP N+++ KI D G A+ E D T +V T Y A Sbjct: 141 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAK----ELDQGSLCTSFVGTLQYLA 196 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE +L + YT ++D WS G + E ++ F + + + + Sbjct: 197 PE-LLEQQKYTVTVDYWSFGTLAFECITGFRPF--LPNWQPVQWHSKVRQKSEVDIVVSE 253 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT 320 + SLP L + L ML ++P +R T Sbjct: 254 DLNGTVKFSSSLPYP-----NNLNSVLAERLEKWLQLMLMWHPRQRGT 296 >3GQL-A nrPDB Length = 326 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 123/294 (41%), Gaps = 33/294 (11%) Query: 25 PGEVEMVKGQPFDVG-PRYTQLQYIGEGAYGMVSSA------YDHVRK-TRVAIKKISPF 76 E E+ + +++ R + +GEGA+G V A D + T+VA+K + Sbjct: 12 VSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD 71 Query: 77 EHQTYCQRTLREIQILLRF-RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS 135 + + E++++ +H+N+I + + IV+ + +L + L++ Sbjct: 72 ATEKDLSDLISEMEMMKMIGKHKNIINLLGACT----QDGPLYVIVEYASKGNLREYLQA 127 Query: 136 QQ-----------------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC 178 ++ LS+ + YQ+ RG++Y+ S +HRDL N+L+ Sbjct: 128 RRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN 187 Query: 179 DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM 238 +KI DFGLAR + + +W APE + + + YT D+WS G +L E+ Sbjct: 188 VMKIADFGLARDIHHIDYYKKTTNGRLPVKW-MAPEALFD-RIYTHQSDVWSFGVLLWEI 245 Query: 239 LS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVA 291 + +PG + + + + M R+ ++PS+ Sbjct: 246 FTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF 299 >3VN9-A nrPDB Length = 340 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 77/312 (24%), Positives = 128/312 (41%), Gaps = 48/312 (15%) Query: 31 VKGQPFDV-GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREI 89 + Q F+V + +G GAYG+V +A+K+I + +R L ++ Sbjct: 41 IGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDL 100 Query: 90 QI-LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL-----KSQQLSNDHI 143 I + + L DV+I +LM+T L K K Q + D + Sbjct: 101 DISMRTVDCPFTVTFYGALFREG-----DVWICMELMDTSLDKFYKQVIDKGQTIPEDIL 155 Query: 144 CYFLYQILRGLKYIHSA-NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLT 202 I++ L+++HS +V+HRD+KPSN+LIN +K+CDFG++ + T Sbjct: 156 GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD----SVAKT 211 Query: 203 EYVATRWYRAPEIM---LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 259 + Y APE + LN KGY+ DIWS+G + E+ R FP + + Sbjct: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQ 269 Query: 260 ILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI 319 ++ PS + K ++ +D + L N +R Sbjct: 270 VVEEPSPQLPAD--------------------------KFSAEFVDFTSQCLKKNSKERP 303 Query: 320 TVEEALAHPYLE 331 T E + HP+ Sbjct: 304 TYPELMQHPFFT 315 >6BDL-A nrPDB Length = 347 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 60/300 (20%), Positives = 120/300 (40%), Gaps = 49/300 (16%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRK-TRVAIKKISPF--EHQTYCQRTLREIQILLRFRHE 98 + + +G G +G V + A+K + + E QI+ + Sbjct: 36 FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSD 95 Query: 99 NVIGIRDILRASTLEAMRDVYIVQD-LMETDLYKLLKSQQ-LSNDHICYFLYQILRGLKY 156 ++ + T + + +Y++ + + +L+ +L+ + + ++ ++ Y Sbjct: 96 FIVRLY-----RTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 150 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 +HS +++RDLKP NL+++ K+ DFG A+ + T Y APEI+ Sbjct: 151 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKI----GFGKKTWTFCGTPEYVAPEII 206 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 LN KG+ S D WS+G ++ E+L+ P F G + N IL Sbjct: 207 LN-KGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILR----------------- 248 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEALAHPYLE 331 + + K A +L+ ++ NP++R+ V++ H + E Sbjct: 249 ------------GIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFE 296 >2DQ7-X nrPDB Length = 283 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 72/318 (22%), Positives = 134/318 (42%), Gaps = 51/318 (16%) Query: 33 GQPFDVGPR-YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQI 91 +++ ++ +G G +G V + T+VAIK + P + L E QI Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMS--PESFLEEAQI 57 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ---LSNDHICYFL 147 + + +H+ ++ + ++ + +YIV + M L LK + L ++ Sbjct: 58 MKKLKHDKLVQLYAVV------SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMA 111 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 Q+ G+ YI N +HRDL+ +N+L+ KI DFGLAR+ + ++++T Sbjct: 112 AQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE-DNEYTARQGAKFPI 170 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQ 266 +W APE L + +T D+WS G +L E+++ R +PG + + L + P Sbjct: 171 KW-TAPEAALYGR-FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCP 228 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 +D ++ +L+ +P +R T E + Sbjct: 229 QDCPISLH------------------------------ELMIHCWKKDPEERPTFEYLQS 258 Query: 327 HPYLEQYYDPTDEPVAEE 344 +LE Y+ T EP + Sbjct: 259 --FLEDYFTAT-EPQYQP 273 >5UNP-A nrPDB Length = 369 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 81/357 (22%), Positives = 136/357 (38%), Gaps = 63/357 (17%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKT-RVAIKKISPFEHQTYCQRTLREIQILLRFR-- 96 RY + +GEG +G V DH R RVA+K I E Y + EI +L + Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVE--KYKEAARLEINVLEKINEK 91 Query: 97 ---HENV-IGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ---QLSNDHICYFLYQ 149 ++N+ + + D + + I +L+ + LK + + +Q Sbjct: 92 DPDNKNLCVQMFDWF-----DYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQ 146 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCD-------------------LKICDFGLARI 190 + + +K++H + H DLKP N+L + +++ DFG A Sbjct: 147 LCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF 206 Query: 191 ADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHY 250 H + V+TR YRAPE++L G+++ D+WS+GCI+ E +F Sbjct: 207 DHEHH------STIVSTRHYRAPEVILE-LGWSQPCDVWSIGCIIFEYYVGFTLFQTHDN 259 Query: 251 LDQLNHILGILGSPSQEDLNCIINMK----------ARNYLQSLPSKTKVAWAKLFPKSD 300 + L + ILG + K + + Sbjct: 260 REHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEA 319 Query: 301 SK---ALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDD 354 + DL++ ML + P KR+T+ EAL HP+ + AE P D Sbjct: 320 EEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLR-------AEPPNKLWDSSRD 369 >3NYO-A nrPDB Length = 576 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 68/320 (21%), Positives = 123/320 (38%), Gaps = 49/320 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT--LREIQILLRFRHEN 99 + Q + +G+G +G V + A KK+ + L E QIL + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKL----LKSQQLSNDHICYFLYQILRGLK 155 V+ + A E + +V LM K + ++ +I GL+ Sbjct: 246 VVSL-----AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 +H +++RDLKP N+L++ ++I D GLA + V T Y APE+ Sbjct: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT----IKGRVGTVGYMAPEV 356 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + N + YT S D W++GC+L EM++ + F Q+ I Sbjct: 357 VKNER-YTFSPDWWALGCLLYEMIAGQSPF--------------------QQRKKKIKRE 395 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEALAHPYL 330 + ++ +P + + +A L ++L +P +R+ + E HP Sbjct: 396 EVERLVKEVPEEYSERF-------SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 Query: 331 EQY-YDPTDEPVAEEPFTFA 349 ++ + + E PF Sbjct: 449 KKLNFKRLGAGMLEPPFKPD 468 >6NPU-A nrPDB Length = 298 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 60/287 (20%), Positives = 112/287 (39%), Gaps = 45/287 (15%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 T +G G YG V VA+K + E + L+E ++ +H N++ Sbjct: 29 TMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK--EDTMEVEEFLKEAAVMKEIKHPNLVQ 86 Query: 103 IRDILRASTLEAMRDVYIVQDLME-TDLYKLLK---SQQLSNDHICYFLYQILRGLKYIH 158 + + YI+ + M +L L+ Q+++ + Y QI ++Y+ Sbjct: 87 LLGVCTRE-----PPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 141 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 N +HRDL N L+ +K+ DFGL+R+ + +T +W APE + Sbjct: 142 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGD-TYTAHAGAKFPIKW-TAPESLAY 199 Query: 219 SKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 +K ++ D+W+ G +L E+ + +PG DL+ + + Sbjct: 200 NK-FSIKSDVWAFGVLLWEIATYGMSPYPGI-------------------DLSQVYELLE 239 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 ++Y P K +L+ +NP+ R + E Sbjct: 240 KDYRMERPE-----------GCPEKVYELMRACWQWNPSDRPSFAEI 275 >2J0K-A nrPDB Length = 656 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 60/292 (20%), Positives = 112/292 (38%), Gaps = 46/292 (15%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRK---TRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 R + IGEG +G V + VAIK + ++ L+E + +F Sbjct: 390 ERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFD 449 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSNDHI--CYFLYQILRG 153 H +++ + ++ V+I+ +L +L L+ ++ S D + YQ+ Sbjct: 450 HPHIVKLIGVITE------NPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTA 503 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 L Y+ S +HRD+ N+L++ T +K+ DFGL+R + + + + +W AP Sbjct: 504 LAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYME-DSTYYKASKGKLPIKW-MAP 561 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 E + N + +T + D+W G + E+L F G D + I P Sbjct: 562 ESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMP------ 614 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 P L+ + ++P++R E Sbjct: 615 ------------------------PNCPPTLYSLMTKCWAYDPSRRPRFTEL 642 >3PFQ-A nrPDB Length = 674 Score = 204 bits (518), Expect = 7e-53, Method: Composition-based stats. Identities = 68/380 (17%), Positives = 137/380 (36%), Gaps = 66/380 (17%) Query: 19 GVGPGVPGEVEMVKGQPFDVGPR--------YTQLQYIGEGAYGMVSSAYDHVRKTRVAI 70 G G P E FD + L +G+G++G V + A+ Sbjct: 312 GQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAV 371 Query: 71 KKISPFE--HQTYCQRTLREIQILLR-FRHENVIGIRDILRASTLEAMRDVYIVQDLMET 127 K + + T+ E ++L + + + S + M +Y V + + Sbjct: 372 KILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH-----SCFQTMDRLYFVMEYVNG 426 Query: 128 D--LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDF 185 +Y + + + H ++ +I GL ++ S +++RDLK N+++++ +KI DF Sbjct: 427 GDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADF 486 Query: 186 GLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 G+ + + T + T Y APEI+ + Y KS+D W+ G +L EML+ + F Sbjct: 487 GMCKENIWDGVTT---KTFCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEMLAGQAPF 542 Query: 246 PGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALD 305 G+ + I+ + + +A+ Sbjct: 543 EGEDEDELFQSIMEHNVAYPK-------------------------------SMSKEAVA 571 Query: 306 LLDRMLTFNPNKRITV-----EEALAHPYLE-QYYDPTDEPVAEEPFTFAMELDDLPKER 359 + ++T +P KR+ + H + ++ + + P+ + E Sbjct: 572 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKASGRN--AEN 629 Query: 360 LKELIFQETARFQPGVLEAP 379 + P VL P Sbjct: 630 FDRFFTR-----HPPVLTPP 644 >2Y6O-A nrPDB Length = 291 Score = 204 bits (518), Expect = 8e-53, Method: Composition-based stats. Identities = 68/286 (23%), Positives = 119/286 (41%), Gaps = 27/286 (9%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTR---VAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 + IG G +G V S V R VAIK + + L E I+ +F H N Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPN 76 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKS--QQLSNDHICYFLYQILRGLKY 156 +I + ++ + V I+ + ME L L+ + + + L I G+KY Sbjct: 77 IIHLEGVVTKC-----KPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKY 131 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD-HTGFLTEYVATRWYRAPEI 215 + + +HRDL N+L+N+ K+ DFG++R+ + + + + RW APE Sbjct: 132 LSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRW-TAPEA 190 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 + + +T + D+WS G ++ E++S + D + I P D ++ Sbjct: 191 IA-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALH 249 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPN--KR 318 + Q S + +++LD+ L NPN KR Sbjct: 250 QLMLDCWQKERSDRPKF---------GQIVNMLDK-LIRNPNSLKR 285 >2PSQ-A nrPDB Length = 370 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 64/320 (20%), Positives = 131/320 (40%), Gaps = 42/320 (13%) Query: 25 PGEVEMVKGQPFDVG-PRYTQLQYIGEGAYGMVSSA----YDHVRKTR---VAIKKISPF 76 E E+ + ++ + T + +GEG +G V A D + VA+K + Sbjct: 65 VSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 124 Query: 77 EHQTYCQRTLREIQILLRF-RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS 135 + + E++++ +H+N+I + + IV+ + +L + L++ Sbjct: 125 ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT----QDGPLYVIVEYASKGNLREYLRA 180 Query: 136 QQ-----------------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC 178 ++ ++ + YQ+ RG++Y+ S +HRDL N+L+ Sbjct: 181 RRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN 240 Query: 179 DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM 238 +KI DFGLAR + + + +W APE + + + YT D+WS G ++ E+ Sbjct: 241 VMKIADFGLARDINNIDYYKKTTNGRLPVKW-MAPEALFD-RVYTHQSDVWSFGVLMWEI 298 Query: 239 LS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFP 297 + +PG + + + + M R+ ++PS+ Sbjct: 299 FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF------ 352 Query: 298 KSDSKALDLLDRMLTFNPNK 317 + ++ LDR+LT N+ Sbjct: 353 ---KQLVEDLDRILTLTTNE 369 >1ZXE-A nrPDB Length = 303 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 128/315 (40%), Gaps = 53/315 (16%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + ++ +G+GA+G V A + + AIKKI E + L E+ +L H+ V+ Sbjct: 8 FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEK--LSTILSEVMLLASLNHQYVV 65 Query: 102 GIRDILRAS--------TLEAMRDVYIVQDLMET-DLYKLLKSQQLSN--DHICYFLYQI 150 ++ ++I + E LY L+ S+ L+ D QI Sbjct: 66 RYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQI 125 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD-----------HTG 199 L L YIHS ++HR+LKP N+ I+ + ++KI DFGLA+ D + Sbjct: 126 LEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSD 185 Query: 200 FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 259 LT + T Y A E++ + Y + ID++S+G I EM+ P G ++ L + Sbjct: 186 NLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI--YPFSTGMERVNILKKLRS 243 Query: 260 ILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI 319 + + + + ++ + ++ ++ +PNKR Sbjct: 244 VSIEFPPDFDDNKMKVEKK---------------------------IIRLLIDHDPNKRP 276 Query: 320 TVEEALAHPYLEQYY 334 L +L + Sbjct: 277 GARTLLNSGWLPVKH 291 >3ORP-A nrPDB Length = 311 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 54/236 (22%), Positives = 97/236 (41%), Gaps = 6/236 (2%) Query: 34 QPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF--EHQTYCQRTLREIQI 91 P + RY + +G G V A D VA+K + ++ R RE Q Sbjct: 6 TPSHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQN 65 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ-QLSNDHICYFLYQ 149 H ++ + D A T YIV + ++ L ++ ++ ++ + Sbjct: 66 AAALNHPAIVAVYDTGEAETPAGPLP-YIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIAD 124 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW 209 + L + H ++HRD+KP+N++I+ T +K+ DFG+AR + + T Sbjct: 125 ACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQ 184 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 Y +PE D++S+GC+L E+L+ P F G + + P Sbjct: 185 YLSPEQARGDSV-DARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPP 239 >4P5Q-A nrPDB Length = 361 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 65/278 (23%), Positives = 115/278 (41%), Gaps = 25/278 (8%) Query: 46 QYIGEGAYGMVSSAYDHVRKTR---VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 + +G G +G V S + + VAIK + + + L E I+ +F H N+I Sbjct: 39 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIR 98 Query: 103 IRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQ--QLSNDHICYFLYQILRGLKYIHS 159 + ++ S + V IV + ME L L+ Q + + L I G+KY+ Sbjct: 99 LEGVVTKS-----KPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSD 153 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD-HTGFLTEYVATRWYRAPEIMLN 218 +HRDL N+LIN+ K+ DFGL+R+ + + + + RW +PE + Sbjct: 154 MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW-TSPEAIA- 211 Query: 219 SKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 + +T + D+WS G +L E++S + D + + P D + Sbjct: 212 YRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLM 271 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 315 + Q + + + +LD+ L NP Sbjct: 272 LDCWQKDRNNRPKF---------EQIVSILDK-LIRNP 299 >4K33-A nrPDB Length = 325 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 62/294 (21%), Positives = 119/294 (40%), Gaps = 33/294 (11%) Query: 25 PGEVEMVKGQPFDVGP-RYTQLQYIGEGAYGMVSSA----YDHVRKTR---VAIKKISPF 76 E+E+ +++ R T + +GEGA+G V A D R + VA+K + Sbjct: 20 VSELELPADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDD 79 Query: 77 EHQTYCQRTLREIQILLRF-RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS 135 + E++++ +H+N+I + + +V+ + +L + L++ Sbjct: 80 ATDKDLSDLVSEMEMMKMIGKHKNIINLLGACT----QGGPLYVLVEYAAKGNLREFLRA 135 Query: 136 QQ-----------------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC 178 ++ L+ + YQ+ RG++Y+ S +HRDL N+L+ Sbjct: 136 RRPPGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDN 195 Query: 179 DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM 238 +KI DFGLAR + + +W APE + + + YT D+WS G +L E+ Sbjct: 196 VMKIADFGLARDVHNLDYYKETTNGRLPVKW-MAPEALFD-RVYTHQSDVWSFGVLLWEI 253 Query: 239 LS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVA 291 + +PG + + + + M R + PS+ Sbjct: 254 FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTF 307 >4E93-A nrPDB Length = 377 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 61/290 (21%), Positives = 105/290 (36%), Gaps = 44/290 (15%) Query: 44 QLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGI 103 + IG G +G V S T VA+K + L+E +IL ++ H N++ + Sbjct: 118 LGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRL 177 Query: 104 RDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQ--QLSNDHICYFLYQILRGLKYIHSA 160 + + +YIV +L+ D L+++ +L + + G++Y+ S Sbjct: 178 IGVCTQ-----KQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESK 232 Query: 161 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 +HRDL N L+ LKI DFG++R V +W APE + N Sbjct: 233 CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW-TAPEAL-NYG 290 Query: 221 GYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN 279 Y+ D+WS G +L E S +P + P E + Sbjct: 291 RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFR---- 346 Query: 280 YLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI---TVEEALA 326 L+++ + P +R T+ + L Sbjct: 347 --------------------------LMEQCWAYEPGQRPSFSTIYQELQ 370 >3FME-A nrPDB Length = 290 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 73/299 (24%), Positives = 122/299 (40%), Gaps = 47/299 (15%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQI-LLRFRHENVI 101 + +G GAYG+V +A+K+I + +R L ++ I + + Sbjct: 10 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 69 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLK-----SQQLSNDHICYFLYQILRGLKY 156 L DV+I +LM+T L K K Q + D + I++ L++ Sbjct: 70 TFYGALFREG-----DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 124 Query: 157 IHSA-NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 +HS +V+HRD+KPSN+LIN +K+CDFG++ + + Y APE Sbjct: 125 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDID----AGCKPYMAPER 180 Query: 216 M---LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 + LN KGY+ DIWS+G + E+ R FP + + ++ PS + Sbjct: 181 INPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSPQLPAD- 237 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 K ++ +D + L N +R T E + HP+ Sbjct: 238 -------------------------KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 271 >5HI2-A nrPDB Length = 283 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 118/285 (41%), Gaps = 20/285 (7%) Query: 32 KGQPFDVGP-RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQ 90 +++ + T Q IG G++G V H VA+K ++P + Q E+ Sbjct: 11 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQ----LQAFKNEVG 63 Query: 91 ILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLKSQ--QLSNDHICYFL 147 +L + RH N++ + IV E LY L + + + Sbjct: 64 VLRKTRHVNILLFMGY------STKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIA 117 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 Q RG+ Y+H+ +++HRDLK +N+ ++ +KI DFGLA + + + Sbjct: 118 RQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLAT-VKSRWSGSHQFEQLSGS 176 Query: 208 RWYRAPEIM--LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 + APE++ +S Y+ D+++ G +L E+++ + + + DQ+ ++G Sbjct: 177 ILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSP 236 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRM 310 K L + K K FP+ ++ +L + Sbjct: 237 DLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 281 >3PPZ-A nrPDB Length = 309 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 68/279 (24%), Positives = 122/279 (43%), Gaps = 31/279 (11%) Query: 44 QLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENVIG 102 + IG G++G V A H + VA+K + + H LRE+ I+ R RH N++ Sbjct: 41 IKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVL 98 Query: 103 IRDILRASTLEAMRDVYIVQDLME-TDLYKLLK----SQQLSNDHICYFLYQILRGLKYI 157 + ++ IV + + LY+LL +QL Y + +G+ Y+ Sbjct: 99 FMGAVTQP-----PNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYL 153 Query: 158 HSAN--VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 H+ N ++HRDLK NLL++ +K+CDFGL+R+ + T + APE+ Sbjct: 154 HNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSS---KSAAGTPEWMAPEV 210 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + + + + D++S G IL E+ + + + + ++ +G C Sbjct: 211 LRD-EPSNEKSDVYSFGVILWELATLQQPWGNLNP----AQVVAAVG------FKCKRLE 259 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKA--LDLLDRMLT 312 RN + + + W K S A +DLL ++ Sbjct: 260 IPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIK 298 >2XNP-A nrPDB Length = 279 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 73/299 (24%), Positives = 124/299 (41%), Gaps = 49/299 (16%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTL-REIQILLRFRHENV 100 Y L IG G+YG + K++ ++ L E+ +L +H N+ Sbjct: 8 YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNI 67 Query: 101 IGIRDILRASTLEAMRDVYIVQDLMET-DLYKLL-----KSQQLSNDHICYFLYQILRGL 154 + D + T +YIV + E DL ++ + Q L + + + Q+ L Sbjct: 68 VRYYDRIIDRT---NTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLAL 124 Query: 155 KYIHS-----ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW 209 K H VLHRDLKP+N+ ++ ++K+ DFGLARI + + T F +V T + Sbjct: 125 KECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHD---TSFAKTFVGTPY 181 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 269 Y +PE +N Y + DIWS+GC+L E+ + P F + I Sbjct: 182 YMSPE-QMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKI------------ 228 Query: 270 NCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 328 + + ++ + + +++ RML R +VEE L +P Sbjct: 229 ------------------REGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENP 269 >2R2P-A nrPDB Length = 295 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 70/282 (24%), Positives = 118/282 (41%), Gaps = 25/282 (8%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTR---VAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 T + IG G +G V S + R VAIK + + + L E I+ +F H N Sbjct: 25 TIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPN 84 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKS--QQLSNDHICYFLYQILRGLKY 156 +I + ++ S + V IV + ME L LK Q + + L I G+KY Sbjct: 85 IIHLEGVVTKS-----KPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKY 139 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD-HTGFLTEYVATRWYRAPEI 215 + +HRDL N+LIN+ K+ DFGL+R+ + + + + RW APE Sbjct: 140 LSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW-TAPEA 198 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 + + +T + D+WS G ++ E++S + D + + PS D + Sbjct: 199 IA-FRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALY 257 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPN 316 + Q + + +++LD+ L NP Sbjct: 258 QLMLDCWQKERNSRPKF---------DEIVNMLDK-LIRNPA 289 >6GVJ-A nrPDB Length = 429 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 76/315 (24%), Positives = 125/315 (39%), Gaps = 50/315 (15%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-EIQILLRFR- 96 G Y+ L+ IG G V + +K AIK ++ E + R EI L + + Sbjct: 143 GRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 201 Query: 97 H-ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGL 154 H + +I + D + +Y+V + DL LK ++ + + +L + Sbjct: 202 HSDKIIRLYDY-----EITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 256 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 IH ++H DLKP+N LI LK+ DFG+A P+ + V T Y PE Sbjct: 257 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPD-TTSVVKDSQVGTVNYMPPE 314 Query: 215 IMLNSKGYTK----------SIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP 264 + + + D+WS+GCIL M + F I+ + Sbjct: 315 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ---------QIINQISK- 364 Query: 265 SQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 L+ II+ +P K D+L L +P +RI++ E Sbjct: 365 ----LHAIIDPNHEIEFPDIPEK--------------DLQDVLKCCLKRDPKQRISIPEL 406 Query: 325 LAHPYLEQYYDPTDE 339 LAHPY++ P ++ Sbjct: 407 LAHPYVQIQTHPVNQ 421 >5KMM-A nrPDB Length = 329 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 67/302 (22%), Positives = 116/302 (38%), Gaps = 39/302 (12%) Query: 17 TEGVGPGVPGEVEMVKGQPF------DVGPRYTQLQ-YIGEGAYGMVSSAYDH-----VR 64 TEG G G+ G + + Q F + R L+ +GEGA+G V A H Sbjct: 6 TEGKGSGLQGHI-IENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQD 64 Query: 65 KTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDL 124 K VA+K + ++ Q RE ++L +H++++ + R + +V + Sbjct: 65 KMLVAVKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEG-----RPLLMVFEY 118 Query: 125 M-ETDLYKLLKSQ----------------QLSNDHICYFLYQILRGLKYIHSANVLHRDL 167 M DL + L+S L + Q+ G+ Y+ + +HRDL Sbjct: 119 MRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL 178 Query: 168 KPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSID 227 N L+ +KI DFG++R + + RW PE +L K +T D Sbjct: 179 ATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRW-MPPESILYRK-FTTESD 236 Query: 228 IWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPS 286 +WS G +L E+ + + + + ++ I + R Q P Sbjct: 237 VWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQ 296 Query: 287 KT 288 + Sbjct: 297 QR 298 >4TNB-A nrPDB Length = 590 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 64/320 (20%), Positives = 120/320 (37%), Gaps = 49/320 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQR--TLREIQILLRFRHEN 99 + Q + +G+G +G V + A K++ + L E QIL + + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKL----LKSQQLSNDHICYFLYQILRGLK 155 V+ + A E + +V +M K + + + ++ +IL GL+ Sbjct: 246 VVNL-----AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 +H N ++RDLKP N+L++ ++I D GLA + V T Y APE+ Sbjct: 301 DLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD----LIRGRVGTVGYMAPEV 356 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + N + Y S D W +GC++ EM+ + F G+ Sbjct: 357 LNNQR-YGLSPDYWGLGCLIYEMIEGQSPFRGR--------------------------- 388 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT-----VEEALAHPYL 330 K + + + + K +A + +LT + +R+ E HP+ Sbjct: 389 KEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFF 448 Query: 331 EQ-YYDPTDEPVAEEPFTFA 349 + + + + PF Sbjct: 449 RNMNFKRLEAGMLDPPFVPD 468 >3M42-A nrPDB Length = 299 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 69/354 (19%), Positives = 132/354 (37%), Gaps = 69/354 (19%) Query: 21 GPGVPGEVEMVKGQPFDVGPRYTQL-QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQ 79 GP V +++ K + Y Q +G G G V ++ + + A+K + Sbjct: 1 GPHVKSGLQIKKNA---IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------ 51 Query: 80 TYCQRTLREIQILLRFRH-ENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ 137 C + RE+++ R +++ I D+ + + IV + ++ +L+ ++ + Sbjct: 52 QDCPKARREVELHWRASQCPHIVRIVDVYENL-YAGRKCLLIVMECLDGGELFSRIQDRG 110 Query: 138 ---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT---TCDLKICDFGLARIA 191 + + I ++Y+HS N+ HRD+KP NLL + LK+ DFG A+ Sbjct: 111 DQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET 170 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 251 E Y KS D+WS+G I+ +L P F H L Sbjct: 171 TGE--------------------------KYDKSCDMWSLGVIMYILLCGYPPFYSNHGL 204 Query: 252 DQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRML 311 ++ + + R P+ + + + L+ +L Sbjct: 205 ----------------AISPGMKTRIRMGQYEFPNPE-------WSEVSEEVKMLIRNLL 241 Query: 312 TFNPNKRITVEEALAHPYLEQYYDPTDEPV-AEEPFTFAMELDDLPKERLKELI 364 P +R+T+ E + HP++ Q P+ E + KE + + Sbjct: 242 KTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 295 >3QA8-A nrPDB Length = 676 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 115/291 (39%), Gaps = 21/291 (7%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + + +G G +G V +VAIK+ +R EIQI+ + H NV+ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVV 75 Query: 102 GIRDILRASTLEAMRDV-YIVQDLME-TDLYKLLKSQQ----LSNDHICYFLYQILRGLK 155 R++ A D+ + + E DL K L + L I L I L+ Sbjct: 76 SAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALR 135 Query: 156 YIHSANVLHRDLKPSNLLINTTCDL---KICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 Y+H ++HRDLKP N+++ KI D G A+ E D TE+V T Y A Sbjct: 136 YLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAK----ELDQGELCTEFVGTLQYLA 191 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE +L K YT ++D WS G + E ++ F Q + + + + + Sbjct: 192 PE-LLEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEHIVVYDDL 250 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEE 323 + + P+ A + L ML ++ +R T + Sbjct: 251 TGAVKFSSVLPTPNHLSGILAGKLERW-------LQCMLMWHQRQRGTDPQ 294 >2XYN-A nrPDB Length = 292 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 58/286 (20%), Positives = 109/286 (38%), Gaps = 45/286 (15%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 T +G G YG V VA+K + E + L+E ++ +H N++ Sbjct: 35 TMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK--EDTMEVEEFLKEAAVMKEIKHPNLVQ 92 Query: 103 IRDILRASTLEAMRDVYIVQDLME-TDLYKLLK---SQQLSNDHICYFLYQILRGLKYIH 158 + + YIV + M +L L+ ++++ + Y QI ++Y+ Sbjct: 93 LLGVCTLE-----PPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 147 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 N +HRDL N L+ +K+ DFGL+R+ + +T +W APE + Sbjct: 148 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGD-TYTAHAGAKFPIKW-TAPESLA- 204 Query: 219 SKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 ++ D+W+ G +L E+ + +PG DL+ + ++ Sbjct: 205 YNTFSIKSDVWAFGVLLWEIATYGMSPYPGI-------------------DLSQVYDLLE 245 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEE 323 + Y P K +L+ ++P R + E Sbjct: 246 KGYRMEQPE-----------GCPPKVYELMRACWKWSPADRPSFAE 280 >3DKO-A nrPDB Length = 318 Score = 200 bits (509), Expect = 8e-52, Method: Composition-based stats. Identities = 64/282 (22%), Positives = 117/282 (41%), Gaps = 23/282 (8%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTR---VAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 + IG G +G V S + R VAIK + + + L E I+ +F H N Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPN 105 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILRGLKY 156 V+ + ++ + V IV + ME D + Q + + L I G++Y Sbjct: 106 VVHLEGVVTRG-----KPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRY 160 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 + +HRDL N+L+N+ K+ DFGL+R+ + + + T + APE + Sbjct: 161 LADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAI 220 Query: 217 LNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + +T + D+WS G ++ E++S + D + I P+ D ++ Sbjct: 221 -QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQ 279 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNK 317 + Q ++ + + +LD+M+ NPN Sbjct: 280 LMLDCWQKERAERPKF---------EQIVGILDKMI-RNPNS 311 >4EQM-A nrPDB Length = 294 Score = 200 bits (509), Expect = 9e-52, Method: Composition-based stats. Identities = 76/299 (25%), Positives = 130/299 (43%), Gaps = 27/299 (9%) Query: 21 GPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEH 78 G + G++ + RY + +G G V A D + +VAIK I P E Sbjct: 1 GSHMIGKI---------INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREK 51 Query: 79 QTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ- 136 + +R RE+ + H+N++ + D+ E Y+V + +E L + ++S Sbjct: 52 EETLKRFEREVHNSSQLSHQNIVSMIDV-----DEEDDCYYLVMEYIEGPTLSEYIESHG 106 Query: 137 QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 LS D F QIL G+K+ H ++HRD+KP N+LI++ LKI DFG+A+ Sbjct: 107 PLSVDTAINFTNQILDGIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALS--ET 164 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQ-LN 255 + T Y +PE + + DI+S+G +L EML P F G+ + + Sbjct: 165 SLTQTNHVLGTVQYFSPE-QAKGEATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIK 223 Query: 256 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFN 314 HI + + + + I + L++ + + + D L +L N Sbjct: 224 HIQDSVPNVTTDVRKDIPQSLSNVILRATEKDKANRYKTI-----QEMKDDLSSVLHEN 277 >5HIE-A nrPDB Length = 302 Score = 200 bits (508), Expect = 9e-52, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 120/286 (41%), Gaps = 21/286 (7%) Query: 32 KGQPFDVGP-RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQ 90 +++ + T Q IG G++G V H VA+K ++P + Q E+ Sbjct: 27 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQ----LQAFKNEVG 79 Query: 91 ILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLK--SQQLSNDHICYFL 147 +L + RH N++ + IV E LY L + + Sbjct: 80 VLRKTRHVNILLFMGY------STKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIA 133 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 Q +G+ Y+H+ +++HRDLK +N+ ++ +KI DFGLA + + + Sbjct: 134 RQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAT-VKSRWSGSHQFEQLSGS 192 Query: 208 RWYRAPEIM--LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 + APE++ + Y+ D+++ G +L E+++ + + + DQ+ ++G Sbjct: 193 ILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSP 252 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRML 311 KA L + K K LFP+ + ++LL R L Sbjct: 253 DLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS-IELLARSL 297 >4LFI-A nrPDB Length = 374 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 74/333 (22%), Positives = 148/333 (44%), Gaps = 53/333 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKK---------------ISPFEHQTYCQRTL 86 Y +G G Y V K ++ IK ++ ++ TL Sbjct: 42 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 101 Query: 87 -----------REIQILLRFR----------HENVIGIRDILRASTLEAMRDVYIVQDLM 125 +E +L R H N+I + DI++ + +V + + Sbjct: 102 PFQKDQYYTNQKE-DVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA---LVFEYV 157 Query: 126 ETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDLKICD 184 + +++L +L++ I ++++++L+ L Y HS ++HRD+KP N++I+ L++ D Sbjct: 158 DNVDFRIL-YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 216 Query: 185 FGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRP 243 +GLA ++ VA+R+++ PE++++ + Y S+D+WS G +LA M+ P Sbjct: 217 WGLAEFYHVNMEYNV----RVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 272 Query: 244 IFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFP------ 297 F G DQL I+ +LG+ E + + + W + Sbjct: 273 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 332 Query: 298 KSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + + +DL+D +L ++ +R+T +EA+ HP+ Sbjct: 333 SGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 365 >5O2B-A nrPDB Length = 285 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 65/315 (20%), Positives = 130/315 (41%), Gaps = 44/315 (13%) Query: 24 VPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYC 82 + E++ V P ++ +G GA+ V D VA ++ + + Sbjct: 2 MEAEMKAVATSPSGRFLKFDI--ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ 59 Query: 83 QRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKS-QQLSN 140 QR E ++L +H N++ D S L+ + + +V +LM L LK + + Sbjct: 60 QRFKEEAEMLKGLQHPNIVRFYDSWE-SILKGKKCIVLVTELMTSGTLKTYLKRFKVMKP 118 Query: 141 DHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLLINT-TCDLKICDFGLARIADPEHDH 197 + + QIL+GL+++H+ ++HRDLK N+ I T +KI D GLA + Sbjct: 119 KVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM-----R 173 Query: 198 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 257 T F + T + APE + + Y +S+D+++ G + EM ++ + Q+ Sbjct: 174 TSFAKSVIGTPEFMAPE--MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRK 231 Query: 258 LGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNK 317 + P A +D + ++++ + N ++ Sbjct: 232 VTSGIKP----------------------------ASFNKVTDPEVKEIIEGCIRQNKSE 263 Query: 318 RITVEEALAHPYLEQ 332 R+++ + L H + + Sbjct: 264 RLSIRDLLNHAFFAE 278 >5EG3-A nrPDB Length = 334 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 65/320 (20%), Positives = 130/320 (40%), Gaps = 42/320 (13%) Query: 25 PGEVEMVKGQPFDVG-PRYTQLQYIGEGAYGMVSSA----YDHVRKTR---VAIKKISPF 76 E E+ + ++ + T + +GEGA+G V A D + VA+K + Sbjct: 19 VSEFELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 78 Query: 77 EHQTYCQRTLREIQILLRF-RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS 135 + + E++++ +H+N+I + + IV + +L + L++ Sbjct: 79 ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT----QDGPLYVIVAYASKGNLREYLRA 134 Query: 136 QQ-----------------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC 178 ++ ++ + YQ+ RG++Y+ S +HRDL N+L+ Sbjct: 135 RRPPGMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN 194 Query: 179 DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM 238 +KI DFGLAR + + +W APE + + + YT D+WS G ++ E+ Sbjct: 195 VMKIADFGLARDINNIDFFKETTNGRLPVKW-MAPEALFD-RVYTHQSDVWSFGVLMWEI 252 Query: 239 LS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFP 297 + +PG + + + + M R+ ++PS+ Sbjct: 253 FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF------ 306 Query: 298 KSDSKALDLLDRMLTFNPNK 317 + ++ LDR+LT N+ Sbjct: 307 ---KQLVEDLDRILTLTTNE 323 >4UY9-A nrPDB Length = 323 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 77/337 (22%), Positives = 130/337 (38%), Gaps = 62/337 (18%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIK--KISPFEHQTY-CQRTLREIQILLRFRHEN 99 T + IG G +G V A+ VA+K + P E + + +E ++ +H N Sbjct: 12 TLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 69 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 +I +R + ++ +V + L ++L +++ D + + QI RG+ Y+H Sbjct: 70 IIALRGVCLKE-----PNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLH 124 Query: 159 SANV---LHRDLKPSNLLIN--------TTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 + +HRDLK SN+LI + LKI DFGLAR H T Sbjct: 125 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR-----EWHRTTKMSAAGT 179 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 + APE++ S ++K D+WS G +L E+L+ F G Sbjct: 180 YAWMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDG----------------- 221 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAH 327 L + +PS +AK L++ +P+ R + L Sbjct: 222 -LAVAYGVAMNKLALPIPSTCPEPFAK-----------LMEDCWNPDPHSRPSFTNIL-- 267 Query: 328 PYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELI 364 +Q + E P L D K ++E+ Sbjct: 268 ---DQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMF 301 >3A4O-X nrPDB Length = 286 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 120/269 (44%), Gaps = 17/269 (6%) Query: 29 EMVKGQPFDVGPR-YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR 87 + +++ ++ +G G +G V Y + T+VA+K + P Q L Sbjct: 1 KPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGY-YNNSTKVAVKTLKPGTMS--VQAFLE 57 Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKS---QQLSNDHI 143 E ++ +H+ ++ + ++ +YI+ + M + L LKS ++ + Sbjct: 58 EANLMKTLQHDKLVRLYAVVTRE-----EPIYIITEYMAKGSLLDFLKSDEGGKVLLPKL 112 Query: 144 CYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE 203 F QI G+ YI N +HRDL+ +N+L++ + KI DFGLAR+ + ++++T Sbjct: 113 IDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE-DNEYTAREGA 171 Query: 204 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILG 262 +W APE + N +T D+WS G +L E+++ + +PG+ D + + Sbjct: 172 KFPIKW-TAPEAI-NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYR 229 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTKVA 291 P E+ + + + + Sbjct: 230 MPRVENCPDELYDIMKMCWKEKAEERPTF 258 >2I0E-A nrPDB Length = 353 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 62/349 (17%), Positives = 131/349 (37%), Gaps = 58/349 (16%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLR-FRHE 98 + L +G+G++G V + A+K + + T+ E ++L + Sbjct: 22 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 81 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILRGLKY 156 + + S + M +Y V + + +Y + + + H ++ +I GL + Sbjct: 82 FLTQLH-----SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 136 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 + S +++RDLK N+++++ +KI DFG+ + + T + T Y APEI+ Sbjct: 137 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT---KTFCGTPDYIAPEII 193 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + Y KS+D W+ G +L EML+ + F G+ + I+ + + Sbjct: 194 A-YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK---------- 242 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV-----EEALAHPYLE 331 +A+ + ++T +P KR+ + H + Sbjct: 243 ---------------------SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFR 281 Query: 332 -QYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP 379 ++ + + P+ + E + P VL P Sbjct: 282 YIDWEKLERKEIQPPYKPKACGRN--AENFDRFFTR-----HPPVLTPP 323 >6FEX-A nrPDB Length = 321 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 71/346 (20%), Positives = 125/346 (36%), Gaps = 72/346 (20%) Query: 22 PGVPGEVEMVKGQPFDVGPRYTQ--LQYIGEGAYGMVSSAY--------------DHVRK 65 PG G+ G P PR + +GEG +G V + + Sbjct: 1 PGAVGD-----GPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKG 55 Query: 66 TR--VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQD 123 VA+K + P + L+E++I+ R + N+I + + + ++ D Sbjct: 56 HPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDD-----PLCMITD 110 Query: 124 LME-TDLYKLLKSQQLSN--------------DHICYFLYQILRGLKYIHSANVLHRDLK 168 ME DL + L + QL + + + QI G++Y+ + N +HRDL Sbjct: 111 YMENGDLNQFLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLA 170 Query: 169 PSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDI 228 N L+ +KI DFG++R + + RW A E +L K +T + D+ Sbjct: 171 TRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRW-MAWECILMGK-FTTASDV 228 Query: 229 WSVGCILAE--MLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPS 286 W+ G L E ML F G + E + N + Sbjct: 229 WAFGVTLWEVLMLCRAQPF----------------GQLTDEQV-------IENAGEFFRD 265 Query: 287 KTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 + + + P +L+ R + +R + H +L + Sbjct: 266 QGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL--HRFLAE 309 >5O2C-A nrPDB Length = 380 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 125/304 (41%), Gaps = 42/304 (13%) Query: 47 YIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENVIGIRD 105 +G GA+ V D VA ++ + + QR E ++L +H N++ D Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 106 ILRASTLEAMRDVYIVQDLM-ETDLYKLLKS-QQLSNDHICYFLYQILRGLKYIHSAN-- 161 S L+ + + +V +LM L LK + + + + QIL+GL+++H+ Sbjct: 92 SWE-SILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 150 Query: 162 VLHRDLKPSNLLINT-TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 ++HRDLK N+ I T +KI D GLA + T F + T + APE + + Sbjct: 151 IIHRDLKCDNIFITGPTGSVKIGDLGLATLM-----RTSFAKSVIGTPEFMAPE--MYEE 203 Query: 221 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNY 280 Y +S+D+++ G + EM ++ + Q+ + P Sbjct: 204 HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKP---------------- 247 Query: 281 LQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEP 340 A +D + ++++ + N ++R+++ + L H + + E Sbjct: 248 ------------ASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVEL 295 Query: 341 VAEE 344 E+ Sbjct: 296 AEED 299 >4PDO-A nrPDB Length = 299 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 59/257 (22%), Positives = 109/257 (42%), Gaps = 14/257 (5%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTR----VAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 T+ + IG G +G V + VAIK + + L E I+ +F H Sbjct: 37 TRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHH 96 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLL--KSQQLSNDHICYFLYQILRGLK 155 N+I + ++ + + I+ + ME L K L K + S + L I G+K Sbjct: 97 NIIRLEGVISKY-----KPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMK 151 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 Y+ + N +HRDL N+L+N+ K+ DFGL+R+ + + + T + + APE Sbjct: 152 YLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEA 211 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 + + + +T + D+WS G ++ E+++ + + + I P+ D I Sbjct: 212 I-SYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIY 270 Query: 275 MKARNYLQSLPSKTKVA 291 Q ++ Sbjct: 271 QLMMQCWQQERARRPKF 287 >5X5O-A nrPDB Length = 310 Score = 197 bits (502), Expect = 6e-51, Method: Composition-based stats. Identities = 71/283 (25%), Positives = 120/283 (42%), Gaps = 56/283 (19%) Query: 49 GEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILR 108 G G++G V A + VA+KK+ E +E +IL H N+I ++ Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLKIE---------KEAEILSVLSHRNIIQFYGVIL 74 Query: 109 ASTLEAMRDVYIVQDLME-TDLYKLL---KSQQLSNDHICYFLYQILRGLKYIHSA---N 161 IV + LY + +S+++ DHI + + +G+ Y+H Sbjct: 75 EPPNYG-----IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVK 129 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKG 221 V+HRDLK N++I LKICDFG +R H+HT ++ V T + APE++ S Sbjct: 130 VIHRDLKSRNVVIAADGVLKICDFGASRF----HNHTTHMS-LVGTFPWMAPEVI-QSLP 183 Query: 222 YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYL 281 +++ D +S G +L EML+ F G E L + +N Sbjct: 184 VSETCDTYSYGVVLWEMLTREVPFKG------------------LEGLQVAWLVVEKNER 225 Query: 282 QSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 ++PS ++A+ LL + + KR + ++ Sbjct: 226 LTIPSSCPRSFAE-----------LLHQCWEADAKKRPSFKQI 257 >4PWN-A nrPDB Length = 274 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 61/292 (20%), Positives = 124/292 (42%), Gaps = 41/292 (14%) Query: 47 YIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENVIGIRD 105 IG G++ V D VA ++ + ++ QR E ++L +H N++ D Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYD 76 Query: 106 ILRASTLEAMRDVYIVQDLM-ETDLYKLLKS-QQLSNDHICYFLYQILRGLKYIHSAN-- 161 ST++ + + +V +LM L LK + + + + QIL+GL+++H+ Sbjct: 77 SWE-STVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135 Query: 162 VLHRDLKPSNLLINT-TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSK 220 ++HRDLK N+ I T +KI D GLA + F + T + APE + + Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLATL----EKRASFAKSVIGTPEFMAPE--MYEE 189 Query: 221 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNY 280 Y +S+D+++ G + EM ++ + Q+ + P+ D I Sbjct: 190 KYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAI-------- 241 Query: 281 LQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 + ++++ + N ++R ++++ L H + ++ Sbjct: 242 --------------------PEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >3HMP-A nrPDB Length = 342 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 76/315 (24%), Positives = 125/315 (39%), Gaps = 50/315 (15%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-EIQILLRFR- 96 G Y+ L+ IG G V + +K AIK ++ E + R EI L + + Sbjct: 55 GRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 113 Query: 97 H-ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGL 154 H + +I + D + +Y+V + DL LK ++ + + +L + Sbjct: 114 HSDKIIRLYDY-----EITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 168 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 IH ++H DLKP+N LI LK+ DFG+A P+ + V T Y PE Sbjct: 169 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPD-TTSVVKDSQVGTVNYMPPE 226 Query: 215 IMLNSKGY----------TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP 264 + + + D+WS+GCIL M + F I+ + Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ---------QIINQISK- 276 Query: 265 SQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 L+ II+ +P K D+L L +P +RI++ E Sbjct: 277 ----LHAIIDPNHEIEFPDIPEK--------------DLQDVLKCCLKRDPKQRISIPEL 318 Query: 325 LAHPYLEQYYDPTDE 339 LAHPY++ P ++ Sbjct: 319 LAHPYVQIQTHPVNQ 333 >4XCU-A nrPDB Length = 300 Score = 197 bits (500), Expect = 9e-51, Method: Composition-based stats. Identities = 59/305 (19%), Positives = 116/305 (38%), Gaps = 55/305 (18%) Query: 40 PRYTQLQYIGEGAYGMVSSAY-------DHVRKTRVAIKKISPFEHQTYCQRTLREIQIL 92 R + +GEG +G V A + + VA+K + + E++++ Sbjct: 17 DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVM 76 Query: 93 LRF-RHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ--------LSNDH 142 RH+N+I + + +Y++ + + +L + L++++ LS Sbjct: 77 KLIGRHKNIINLLGVCTQEG-----PLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPV 131 Query: 143 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLT 202 + YQ+ RG++Y+ S +HRDL N+L+ +KI DFGLAR + Sbjct: 132 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN 191 Query: 203 EYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGIL 261 + +W APE + + + YT D+WS G +L E+ + +PG + + + Sbjct: 192 GRLPVKW-MAPEALFD-RVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH 249 Query: 262 GSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 321 P + L+ P++R T Sbjct: 250 RMDRP------------------------------PHCPPELYGLMRECWHAAPSQRPTF 279 Query: 322 EEALA 326 ++ + Sbjct: 280 KQLVE 284 >3V5Q-A nrPDB Length = 297 Score = 197 bits (500), Expect = 9e-51, Method: Composition-based stats. Identities = 65/304 (21%), Positives = 115/304 (37%), Gaps = 60/304 (19%) Query: 44 QLQYIGEGAYGMVSSAYDH-----VRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 + +GEGA+G V A + K VA+K + + RE ++L +HE Sbjct: 19 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKD-PTLAARKDFQREAELLTNLQHE 77 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQ-----------------QLSN 140 +++ + + +V + M DL K L++ +L Sbjct: 78 HIVKFYGVCGDGD-----PLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGL 132 Query: 141 DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGF 200 + + QI G+ Y+ S + +HRDL N L+ +KI DFG++R + Sbjct: 133 SQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVG 192 Query: 201 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI 260 + RW PE ++ K +T D+WS G IL E+ + GK QL+ Sbjct: 193 GHTMLPIRW-MPPESIMYRK-FTTESDVWSFGVILWEIFT-----YGKQPWFQLS----- 240 Query: 261 LGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT 320 + E + CI + + P + D++ P +R+ Sbjct: 241 ----NTEVIECITQGRVLERPRVCPK---------------EVYDVMLGCWQREPQQRLN 281 Query: 321 VEEA 324 ++E Sbjct: 282 IKEI 285 >5H2U-A nrPDB Length = 267 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 62/258 (24%), Positives = 113/258 (43%), Gaps = 18/258 (6%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 +T + +G G +G V R +VAIK IS ++ + Q EIQ + + RH++ Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKDR-VQVAIKVISR-DNLLHQQMLQSEIQAMKKLRHKH 63 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKS---QQLSNDHICYFLYQILRGLK 155 ++ + ++ VYI+ +LM + L +LL+ + L + +Q+ G+ Sbjct: 64 ILALYAVVSVGD-----PVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMC 118 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW-YRAPE 214 Y+ S N +HRDL N+L+ K+ DFGLAR+ + +L+ + + APE Sbjct: 119 YLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKED----VYLSHDHNIPYKWTAPE 174 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 + + Y+ D+WS G +L EM S + +PG + + P + + Sbjct: 175 AL-SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSV 233 Query: 274 NMKARNYLQSLPSKTKVA 291 + P + Sbjct: 234 HKLMLTCWCRDPEQRPTF 251 >3OMV-A nrPDB Length = 307 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 115/271 (42%), Gaps = 17/271 (6%) Query: 47 YIGEGAYGMVSSAYDHVRKTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENVIGIRD 105 IG G++G V H VA+K + + Q E+ +L + RH N++ Sbjct: 43 RIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMG 99 Query: 106 ILRASTLEAMRDVYIVQDLMETD-LYKLLKSQ--QLSNDHICYFLYQILRGLKYIHSANV 162 + L IV E LYK L Q + + Q +G+ Y+H+ N+ Sbjct: 100 YMTKDNLA------IVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNI 153 Query: 163 LHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM--LNSK 220 +HRD+K +N+ ++ +KI DFGLA + + + + + APE++ ++ Sbjct: 154 IHRDMKSNNIFLHEGLTVKIGDFGLAT-VKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNN 212 Query: 221 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNY 280 ++ D++S G +L E+++ + + DQ+ ++G + KA Sbjct: 213 PFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKR 272 Query: 281 LQSLPSKTKVAWAKLFPKSDSKALDLLDRML 311 L + K LFP+ S ++LL L Sbjct: 273 LVADCVKKVKEERPLFPQILSS-IELLQHSL 302 >5X02-A nrPDB Length = 347 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 61/295 (20%), Positives = 115/295 (38%), Gaps = 39/295 (13%) Query: 43 TQLQYIGEGAYGMVSSAY-----DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF-R 96 + +G GA+G V +A +VA+K + + + + E++++ + Sbjct: 51 EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGS 110 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ--LSNDHICY-------- 145 HEN++ + S +Y++ + DL L+S++ S D I Y Sbjct: 111 HENIVNLLGACTLSG-----PIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEE 165 Query: 146 --------------FLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA 191 F YQ+ +G++++ + +HRDL N+L+ +KICDFGLAR Sbjct: 166 EEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI 225 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHY 250 + ++ + +W APE + YT D+WS G +L E+ S +PG Sbjct: 226 MSDSNYVVRGNARLPVKW-MAPESLFEG-IYTIKSDVWSYGILLWEIFSLGVNPYPGIPV 283 Query: 251 LDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALD 305 ++ Q + S+ + ++ L + D Sbjct: 284 DANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLAD 338 >4AT3-A nrPDB Length = 299 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 56/267 (20%), Positives = 102/267 (38%), Gaps = 29/267 (10%) Query: 44 QLQYIGEGAYGMVSSAYDH-----VRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 + +GEGA+G V A + K VA+K + + RE ++L +HE Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASD-NARKDFHREAELLTNLQHE 75 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQ--------------QLSNDHI 143 +++ + + +V + M DL K L++ +L+ + Sbjct: 76 HIVKFYGVCVEGD-----PLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQM 130 Query: 144 CYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE 203 + QI G+ Y+ S + +HRDL N L+ +KI DFG++R + Sbjct: 131 LHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHT 190 Query: 204 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILG 262 + RW PE ++ K +T D+WS+G +L E+ + + + + + I Sbjct: 191 MLPIRW-MPPESIMYRK-FTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV 248 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTK 289 + Q P K Sbjct: 249 LQRPRTCPQEVYELMLGCWQREPHMRK 275 >2OGV-A nrPDB Length = 317 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 55/249 (22%), Positives = 101/249 (40%), Gaps = 25/249 (10%) Query: 18 EGVGPGVPGEVEMVKGQPFDVGPR-YTQLQYIGEGAYGMVSSAYDHVRKT-----RVAIK 71 EG ++ + ++ + +G GA+G V A +VA+K Sbjct: 15 EGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVK 74 Query: 72 KISPFEHQTYCQRTLREIQILLRF-RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLY 130 + H + + E++I+ +HEN++ + + I + DL Sbjct: 75 MLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT----HGGPVLVITEYCCYGDLL 130 Query: 131 KLLKS-----------QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD 179 L+ + L + +F Q+ +G+ ++ S N +HRD+ N+L+ Sbjct: 131 NFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHV 190 Query: 180 LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239 KI DFGLAR + ++ + +W APE + + YT D+WS G +L E+ Sbjct: 191 AKIGDFGLARDIMNDSNYIVKGNARLPVKW-MAPESIFDC-VYTVQSDVWSYGILLWEIF 248 Query: 240 S-NRPIFPG 247 S +PG Sbjct: 249 SLGLNPYPG 257 >3CJF-A nrPDB Length = 309 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 70/308 (22%), Positives = 124/308 (40%), Gaps = 54/308 (17%) Query: 40 PRYTQLQYIGEGAYGMVSSA----YDHV-RKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 R + +G GA+G V A D VA+K + + + + E++IL+ Sbjct: 27 DRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIH 86 Query: 95 F-RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-------------LSN 140 H NV+ + + IV+ +L L+S++ L+ Sbjct: 87 IGHHLNVVNLLGACTKP---GGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTL 143 Query: 141 DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGF 200 +H+ + +Q+ +G++++ S +HRDL N+L++ +KICDFGLAR + D+ Sbjct: 144 EHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRK 203 Query: 201 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILG 259 + +W APE + + + YT D+WS G +L E+ S +PG ++ Sbjct: 204 GDARLPLKW-MAPETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCR--- 258 Query: 260 ILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI 319 L M+A +Y P+ LD P++R Sbjct: 259 --------RLKEGTRMRAPDYT--------------TPEMYQTMLD----CWHGEPSQRP 292 Query: 320 TVEEALAH 327 T E + H Sbjct: 293 TFSELVEH 300 >4IAN-A nrPDB Length = 358 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 85/332 (25%), Positives = 147/332 (44%), Gaps = 44/332 (13%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVR-KTRVAIKKISPFEHQTYCQRTLREIQILLRF 95 + RY Y G+G + V A D+ R VA+K I E + L+E++ L + Sbjct: 27 VLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNE--LMQKTGLKELEFLKKL 84 Query: 96 RHENVI-GIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ----LSNDHICYFLYQI 150 + + + + +V + + +L ++LK L + + Q+ Sbjct: 85 NDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQL 144 Query: 151 LRGLKYIHSANVLHRDLKPSNLLINTTCDL-KICDFGLARIADPEHDHTGFLTEYVATRW 209 LK + N+LH D+KP N+L+N + + K+CDFG A +T Y+ +R+ Sbjct: 145 FLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND-----ITPYLVSRF 199 Query: 210 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 269 YRAPEI++ K Y ID+WSVGC L E+ + + +FPGK L + + G + + Sbjct: 200 YRAPEIIIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMI 258 Query: 270 N--------------------CIINMKARNYLQSLPSKTKVAWAKL-----FPKSDSK-- 302 + + + + S + TK A L P+ K Sbjct: 259 RKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKV 318 Query: 303 --ALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 DLLD++L +P KRI++ +AL H ++++ Sbjct: 319 HQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >3G0E-A nrPDB Length = 336 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 67/314 (21%), Positives = 119/314 (37%), Gaps = 63/314 (20%) Query: 40 PRYTQLQYIGEGAYGMVSSA-----YDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 R + + +G GA+G V A VA+K + P H T + + E+++L Sbjct: 46 NRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSY 105 Query: 95 F-RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLS-------------- 139 H N++ + + I + DL L+ ++ S Sbjct: 106 LGNHMNIVNLLGACTIGG----PTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDD 161 Query: 140 -----NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPE 194 + + F YQ+ +G+ ++ S N +HRDL N+L+ KICDFGLAR + Sbjct: 162 ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND 221 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQ 253 ++ + +W APE + N YT D+WS G L E+ S +PG + Sbjct: 222 SNYVVKGNARLPVKW-MAPESIFNC-VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSK 279 Query: 254 LNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPK-SDSKALDLLDRMLT 312 ++ K + L P+ + ++ D++ Sbjct: 280 FYKMI------------------------------KEGFRMLSPEHAPAEMYDIMKTCWD 309 Query: 313 FNPNKRITVEEALA 326 +P KR T ++ + Sbjct: 310 ADPLKRPTFKQIVQ 323 >2X7G-A nrPDB Length = 389 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 89/378 (23%), Positives = 145/378 (38%), Gaps = 90/378 (23%) Query: 35 PFDVGP----RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQ 90 P +G RY ++ +G G + V +D K VA+K + +H Y + L EI+ Sbjct: 22 PVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQH--YTETALDEIK 79 Query: 91 ILLRFR-----HEN---VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL---KSQQLS 139 +L R N V+ + D + S + + V +V +++ L K + Q L Sbjct: 80 LLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIH-VCMVFEVLGHHLLKWIIKSNYQGLP 138 Query: 140 NDHICYFLYQILRGLKYIHSA-NVLHRDLKPSNLLINTTC-------------------- 178 + + Q+L+GL Y+HS ++H D+KP N+L+ Sbjct: 139 VRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPP 198 Query: 179 ---------------------------DLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 +KI D G A TE + TR YR Sbjct: 199 PSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKH------FTEDIQTRQYR 252 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKH------YLDQLNHILGILGS-P 264 + E+++ + GY+ DIWS C+ E+ + +F D + HI+ +LGS P Sbjct: 253 SIEVLIGA-GYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIP 311 Query: 265 SQEDLNCIINMKARNYLQSLPSKTKVAWAKLF----------PKSDSKALDLLDRMLTFN 314 L+ + + N L TK+ LF + ++ D L ML Sbjct: 312 RHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMV 371 Query: 315 PNKRITVEEALAHPYLEQ 332 P KR + E L HP+L Sbjct: 372 PEKRASAGECLRHPWLNS 389 >5AP3-A nrPDB Length = 313 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 81/333 (24%), Positives = 131/333 (39%), Gaps = 51/333 (15%) Query: 22 PGVPGEVEMVKGQPFDVGPR-YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQT 80 GV E + Q V R Y+ L+ IG G V + +K AIK ++ E Sbjct: 9 SGVDLGTENLYFQSMSVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADN 67 Query: 81 YCQRTLR-EIQILLRFR-H-ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ 137 + R EI L + + H + +I + D + +Y+V + DL LK ++ Sbjct: 68 QTLDSYRNEIAYLNKLQQHSDKIIRLYDY-----EITDQYIYMVMECGNIDLNGWLKKKK 122 Query: 138 -LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 + + +L + IH ++H DLKP+N LI LK+ DFG+A P+ Sbjct: 123 SIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPD-T 180 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTK----------SIDIWSVGCILAEMLSNRPIFP 246 + V T Y PE + + + D+WS+GCIL M + F Sbjct: 181 TSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ 240 Query: 247 GKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDL 306 I+ + L+ II+ +P K D+ Sbjct: 241 ---------QIINQISK-----LHAIIDPNHEIEFPDIPEK--------------DLQDV 272 Query: 307 LDRMLTFNPNKRITVEEALAHPYLEQYYDPTDE 339 L L +P +RI++ E LAHPY++ P ++ Sbjct: 273 LKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQ 305 >1LUF-A nrPDB Length = 343 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 56/283 (19%), Positives = 103/283 (36%), Gaps = 39/283 (13%) Query: 43 TQLQYIGEGAYGMVSSAYD-----HVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 ++ IGEGA+G V A + T VA+K + RE ++ F + Sbjct: 50 EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDN 109 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKS--------------------- 135 N++ + + + + ++ + M DL + L+S Sbjct: 110 PNIVKLLGVCAVG-----KPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVS 164 Query: 136 ----QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA 191 LS Q+ G+ Y+ +HRDL N L+ +KI DFGL+R Sbjct: 165 SPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNI 224 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHY 250 + + + RW PE + ++ YT D+W+ G +L E+ S + G + Sbjct: 225 YSADYYKADGNDAIPIRW-MPPESIFYNR-YTTESDVWAYGVVLWEIFSYGLQPYYGMAH 282 Query: 251 LDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWA 293 + + ++ E+ + R LP+ + Sbjct: 283 EEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCS 325 >2VD5-A nrPDB Length = 412 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 57/326 (17%), Positives = 113/326 (34%), Gaps = 49/326 (15%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQR--TLREIQILLRFRH 97 + L+ IG GA+ V+ A+K ++ ++ + E +L+ Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDL-METDLYKLLKS--QQLSNDHICYFLYQILRGL 154 + + + +Y+V + + DL LL +++ + ++L +I+ + Sbjct: 121 RWITQLH-----FAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAI 175 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 +H +HRD+KP N+L++ +++ DFG + + V T Y +PE Sbjct: 176 DSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLV--AVGTPDYLSPE 233 Query: 215 IML------NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 I+ + Y D W++G EM + F + I+ S Sbjct: 234 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPL 293 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI---TVEEAL 325 ++ +A D + R+L P R+ + Sbjct: 294 VDE--------------------------GVPEEARDFIQRLLCP-PETRLGRGGAGDFR 326 Query: 326 AHPYLEQYYDPTDEPVAEEPFTFAME 351 HP+ D + PFT E Sbjct: 327 THPFFF-GLDWDGLRDSVPPFTPDFE 351 >3BBT-B nrPDB Length = 328 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 55/304 (18%), Positives = 120/304 (39%), Gaps = 18/304 (5%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRV----AIKKISPFEHQTYCQRTLREIQILLRFRHE 98 +++ +G GA+G V V AIK ++ + E I+ H Sbjct: 18 KRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHP 77 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ--LSNDHICYFLYQILRGLK 155 +++ + + + T++ +V LM L + + + + + + + QI +G+ Sbjct: 78 HLVRLLGVCLSPTIQ------LVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMM 131 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 Y+ ++HRDL N+L+ + +KI DFGLAR+ + + + +W A E Sbjct: 132 YLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKW-MALEC 190 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 + + + +T D+WS G + E+++ + G + + + P + Sbjct: 191 I-HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVY 249 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 334 M + + ++ + +L + A D R L + R+ + + + Sbjct: 250 MVMVKCWM-IDADSRPKFKELAAEFSRMARD-PQRYLVIQGDDRMKLPSPNDSKFFQNLL 307 Query: 335 DPTD 338 D D Sbjct: 308 DEED 311 >4XUF-A nrPDB Length = 297 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 57/249 (22%), Positives = 105/249 (42%), Gaps = 39/249 (15%) Query: 43 TQLQYIGEGAYGMVSSAY-----DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF-R 96 + +G GA+G V +A +VA+K + + + + E++++ + Sbjct: 12 EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGS 71 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ--LSNDHICY-------- 145 HEN++ + S +Y++ + DL L+S++ S D I Y Sbjct: 72 HENIVNLLGACTLSG-----PIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEE 126 Query: 146 --------------FLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA 191 F YQ+ +G++++ + +HRDL N+L+ +KICDFGLAR Sbjct: 127 EEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI 186 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHY 250 + ++ + +W APE + YT D+WS G +L E+ S +PG Sbjct: 187 MSDSNYVVRGNARLPVKW-MAPESLFEG-IYTIKSDVWSYGILLWEIFSLGVNPYPGIPV 244 Query: 251 LDQLNHILG 259 ++ Sbjct: 245 DANFYKLIQ 253 >5KKR-C nrPDB Length = 395 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 63/309 (20%), Positives = 125/309 (40%), Gaps = 27/309 (8%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 + ++ +G G G+V +A K I + +RE+Q+L Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 127 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYK--LLKSQQLSNDHICYFLYQILRGLKYI 157 ++G + ++ I + M+ L K+ ++ + +++GL Y+ Sbjct: 128 IVGFYGAFYSDG-----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 182 Query: 158 -HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 ++HRD+KPSN+L+N+ ++K+CDFG++ +V TR Y +PE + Sbjct: 183 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-----SMANSFVGTRSYMSPERL 237 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + Y+ DIWS+G L EM R P + + + E Sbjct: 238 QGT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 296 Query: 277 ARNYLQSLPSKTKVAWAKLF--------PKSDS-----KALDLLDRMLTFNPNKRITVEE 323 + S+ +A +L PK S + D +++ L NP +R +++ Sbjct: 297 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQ 356 Query: 324 ALAHPYLEQ 332 + H ++++ Sbjct: 357 LMVHAFIKR 365 >4AN9-A nrPDB Length = 301 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 61/296 (20%), Positives = 125/296 (42%), Gaps = 43/296 (14%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 + ++ +G G G+V +A K I + +RE+Q+L Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 68 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYK--LLKSQQLSNDHICYFLYQILRGLKYI 157 ++G + ++ I + M+ L K+ ++ + +++GL Y+ Sbjct: 69 IVGFYGAFYSDG-----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 123 Query: 158 -HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 ++HRD+KPSN+L+N+ ++K+CDFG++ E E+V TR Y +PE + Sbjct: 124 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDE-----MANEFVGTRSYMSPERL 178 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + Y+ DIWS+G L EM R P + L++I+ P + + + ++ Sbjct: 179 QGT-HYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIV---NEPPPKLPSAVFSL- 233 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332 + D +++ L NP +R +++ + H ++++ Sbjct: 234 -------------------------EFQDFVNKCLIKNPAERADLKQLMVHAFIKR 264 >3LZB-A nrPDB Length = 327 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 114/272 (41%), Gaps = 17/272 (6%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRV----AIKKISPFEHQTYCQRTLREIQILLRFRH 97 + +++ +G GA+G V +V AIK++ + L E ++ + Sbjct: 17 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 76 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ--LSNDHICYFLYQILRGL 154 +V + I ST++ ++ LM L ++ + + + ++ + QI +G+ Sbjct: 77 PHVCRLLGICLTSTVQ------LITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGM 130 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 Y+ ++HRDL N+L+ T +KI DFGLA++ E V +W A E Sbjct: 131 NYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW-MALE 189 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 +L+ + YT D+WS G + E+++ + G + + + P + Sbjct: 190 SILH-RIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDV 248 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALD 305 M R + + ++ + +L + A D Sbjct: 249 YMIMRKCWM-IDADSRPKFRELIIEFSKMARD 279 >3DTC-A nrPDB Length = 271 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 68/268 (25%), Positives = 114/268 (42%), Gaps = 33/268 (12%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIK--KISPFEHQTY-CQRTLREIQILLRFRHEN 99 T + IG G +G V A+ VA+K + P E + + +E ++ +H N Sbjct: 10 TLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 67 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 +I +R + ++ +V + L ++L +++ D + + QI RG+ Y+H Sbjct: 68 IIALRGVCLKE-----PNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLH 122 Query: 159 SANV---LHRDLKPSNLLIN--------TTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 + +HRDLK SN+LI + LKI DFGLAR H Sbjct: 123 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR-----EWHRTTKMSAAGA 177 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKH-----YLDQLNHILGILG 262 + APE++ S ++K D+WS G +L E+L+ F G Y +N + + Sbjct: 178 YAWMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIP 236 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTKV 290 S E ++ S PS T + Sbjct: 237 STCPEPFAKLMEDCWNPDPHSRPSFTNI 264 >3BEA-A nrPDB Length = 333 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 56/253 (22%), Positives = 102/253 (40%), Gaps = 29/253 (11%) Query: 18 EGVGPGVPGEVEMVKGQPFDVGPR-YTQLQYIGEGAYGMVSSAYDHVRKT-----RVAIK 71 EG ++ + ++ + +G GA+G V A +VA+K Sbjct: 23 EGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVK 82 Query: 72 KISPFEHQTYCQRTLREIQILLRF-RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLY 130 + H + + E++I+ +HEN++ + + I + DL Sbjct: 83 MLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT----HGGPVLVITEYCCYGDLL 138 Query: 131 KLLKSQ---------------QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN 175 L+ + LS + +F Q+ +G+ ++ S N +HRD+ N+L+ Sbjct: 139 NFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT 198 Query: 176 TTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL 235 KI DFGLAR + ++ + +W APE + + YT D+WS G +L Sbjct: 199 NGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKW-MAPESIFDC-VYTVQSDVWSYGILL 256 Query: 236 AEMLS-NRPIFPG 247 E+ S +PG Sbjct: 257 WEIFSLGLNPYPG 269 >2JD5-A nrPDB Length = 373 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 80/347 (23%), Positives = 141/347 (40%), Gaps = 50/347 (14%) Query: 25 PGEVEMV-KGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ 83 PG KG+P+ RY ++ +G G + V A D V T VA+K + + Y + Sbjct: 4 PGGFHPAFKGEPYKDA-RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR--GDKVYTE 60 Query: 84 RTLREIQILLRFRHE-----------NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKL 132 EI++L R +++ + D + V +V +++ +L L Sbjct: 61 AAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVH-VVMVFEVLGENLLAL 119 Query: 133 LKS---QQLSNDHICYFLYQILRGLKYIHSA-NVLHRDLKPSNLLINTTC------DLKI 182 +K + + ++ Q+L GL Y+H ++H D+KP N+L+ +KI Sbjct: 120 IKKYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKI 179 Query: 183 CDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 242 D G A D + T + TR YR+PE++L + + DIWS C++ E+++ Sbjct: 180 ADLGNACWYDEHY------TNSIQTREYRSPEVLLGA-PWGCGADIWSTACLIFELITGD 232 Query: 243 PIFPGKH------YLDQLNHILGILGSPSQEDLNCIINMKA--------RNYLQSLPSKT 288 +F D + I+ +LG L + RN + Sbjct: 233 FLFEPDEGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPL 292 Query: 289 KVAWAKLFPKSDSKAL---DLLDRMLTFNPNKRITVEEALAHPYLEQ 332 + + + S +A D L ML +P KR + HP+L+ Sbjct: 293 EDVLTEKYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKD 339 >5GNK-A nrPDB Length = 297 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 58/286 (20%), Positives = 119/286 (41%), Gaps = 18/286 (6%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRV----AIKKISPFEHQTYCQRTLREIQILLRFRH 97 + +++ +G GA+G V +V AIK++ + L E ++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 80 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ--LSNDHICYFLYQILRGL 154 +V + I ST++ ++ LM L ++ + + + ++ + QI +G+ Sbjct: 81 PHVCRLLGICLTSTVQ------LIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGM 134 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 Y+ ++HRDL N+L+ T +KI DFGLA++ E V +W A E Sbjct: 135 NYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW-MALE 193 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 +L+ + YT D+WS G + E+++ + G + + + P + Sbjct: 194 SILH-RIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDV 252 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI 319 M + + ++ + +L + A D R L ++R+ Sbjct: 253 YMIMVKCWM-IDADSRPKFRELIIEFSKMARD-PQRYLVIQGDERM 296 >3DLS-A nrPDB Length = 335 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 64/327 (19%), Positives = 122/327 (37%), Gaps = 56/327 (17%) Query: 22 PGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY 81 P E+E + + +Y+ + +G GA+G V +A D + V +K I + Sbjct: 6 PPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLED 65 Query: 82 CQ-------RTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET--DLYKL 132 C + EI IL R H N+I + DI +V + + DL+ Sbjct: 66 CWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQ-----LVMEKHGSGLDLFAF 120 Query: 133 LKSQ-QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA 191 + +L Y Q++ + Y+ +++HRD+K N++I +K+ DFG A Sbjct: 121 IDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYL 180 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 251 + + T Y APE+++ + +++WS+G L ++ F Sbjct: 181 ----ERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFC----- 231 Query: 252 DQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRML 311 +L + P + + L+ +L Sbjct: 232 -ELEETVEAAIHPPY-------------------------------LVSKELMSLVSGLL 259 Query: 312 TFNPNKRITVEEALAHPYLEQYYDPTD 338 P +R T+E+ + P++ Q + D Sbjct: 260 QPVPERRTTLEKLVTDPWVTQPVNLAD 286 >4UYA-A nrPDB Length = 340 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 72/311 (23%), Positives = 112/311 (36%), Gaps = 58/311 (18%) Query: 32 KGQPFDVG-PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYC---QRTLR 87 +G P V R + IG G +G V A VA+K Q + R Sbjct: 17 QGSPVHVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRR 74 Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLKSQQLSNDHICYF 146 E ++ RH N+I +R + + +V + L + L +++ + + Sbjct: 75 EARLFAMLRHPNIIELRGVCLQQ-----PHLCLVLEFARGGALNRALAGRRIPPHVLVNW 129 Query: 147 LYQILRGLKYIHSAN---VLHRDLKPSNLLINT--------TCDLKICDFGLARIADPEH 195 QI RG+ Y+H +LHRDLK SN+L+ LKI DFGLAR Sbjct: 130 AVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR-----E 184 Query: 196 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLN 255 H + APE++ S ++K DIWS G +L E+L+ + G Sbjct: 185 WHRTTKMATAGAYAWMAPEVI-KSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDG----- 238 Query: 256 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 315 L + +PS +AK L+ +P Sbjct: 239 -------------LAVAYGVAVNKLTLPIPSTCPEPFAK-----------LMKECWQQDP 274 Query: 316 NKRITVEEALA 326 + R + L Sbjct: 275 HIRPSFALILE 285 >3KRL-A nrPDB Length = 335 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 56/255 (21%), Positives = 104/255 (40%), Gaps = 31/255 (12%) Query: 18 EGVGPGVPGEVEMVKGQPFDVGPR-YTQLQYIGEGAYGMVSSAYDHVRKT-----RVAIK 71 EG ++ + ++ + +G GA+G V A +VA+K Sbjct: 23 EGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVK 82 Query: 72 KISPFEHQTYCQRTLREIQILLRF-RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLY 130 + H + + E++I+ +HEN++ + + I + DL Sbjct: 83 MLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT----HGGPVLVITEYCCYGDLL 138 Query: 131 KLLKSQQ-----------------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL 173 L+ ++ LS+ + +F Q+ +G+ ++ S N +HRD+ N+L Sbjct: 139 NFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVL 198 Query: 174 INTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGC 233 + KI DFGLAR + ++ + +W APE + + YT D+WS G Sbjct: 199 LTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKW-MAPESIFDC-VYTVQSDVWSYGI 256 Query: 234 ILAEMLS-NRPIFPG 247 +L E+ S +PG Sbjct: 257 LLWEIFSLGLNPYPG 271 >2HK5-A nrPDB Length = 270 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 123/269 (45%), Gaps = 18/269 (6%) Query: 29 EMVKGQPFDVGPRYTQLQY-IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR 87 + + +++ +L+ +G G +G V A + + T+VA+K + P + L Sbjct: 3 KPWEKDAWEIPRESLKLEKKLGAGQFGEVWMAT-YNKHTKVAVKTMKPGSMS--VEAFLA 59 Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQLS---NDHI 143 E ++ +H+ ++ + ++ +YI+ + M + L LKS + S + Sbjct: 60 EANVMKTLQHDKLVKLHAVV------TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKL 113 Query: 144 CYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE 203 F QI G+ +I N +HRDL+ +N+L++ + KI DFGLAR+ + ++++T Sbjct: 114 IDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIE-DNEYTAREGA 172 Query: 204 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILG 262 +W APE + N +T D+WS G +L E+++ R +PG + + + Sbjct: 173 KFPIKW-TAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYR 230 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTKVA 291 P E+ + ++ P + Sbjct: 231 MPRPENCPEELYNIMMRCWKNRPEERPTF 259 >6BXI-A nrPDB Length = 333 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 58/279 (20%), Positives = 107/279 (38%), Gaps = 43/279 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ--RTLREIQILLRFRHEN 99 + L+ IG GA+G V A+K + + Q E IL+ Sbjct: 8 FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW 67 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL-KSQQLSNDHICYFLYQILRGLKYI 157 V+ + + + ++Y++ + + D+ LL K L+ + +++ + + + I Sbjct: 68 VVKMF-----YSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSI 122 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH---------------------- 195 H +HRD+KP NLL+++ +K+ DFGL H Sbjct: 123 HQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMN 182 Query: 196 ----------DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF 245 + V T Y APE+ + + GY K D WS+G I+ EML P F Sbjct: 183 SKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQT-GYNKLCDWWSLGVIMYEMLIGYPPF 241 Query: 246 PGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSL 284 + + ++ + + I+ KA++ + Sbjct: 242 CSETPQETYKKVMNWKETLTFPP-EVPISEKAKDLILRF 279 >4XLV-A nrPDB Length = 328 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 72/333 (21%), Positives = 124/333 (37%), Gaps = 68/333 (20%) Query: 24 VPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSS--AYDHVRKT---RVAIKKISPFEH 78 VP E E+ + + T L+ +G+G++GMV A D ++ RVA+K ++ Sbjct: 30 VPDEWEVSR-------EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESAS 82 Query: 79 QTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKS-- 135 L E ++ F +V+ + ++ + +V +LM DL L+S Sbjct: 83 LRERIEFLNEASVMKGFTCHHVVRLLGVVSKG-----QPTLVVMELMAHGDLKSYLRSLR 137 Query: 136 ---------QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFG 186 + + +I G+ Y+++ +HRDL N ++ +KI DFG Sbjct: 138 PEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFG 197 Query: 187 LARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIF 245 + R + + RW APE + + +T S D+WS G +L E+ S + Sbjct: 198 MTRDIYETDYYRKGGKGLLPVRW-MAPESLKDG-VFTTSSDMWSFGVVLWEITSLAEQPY 255 Query: 246 PGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALD 305 G L ++ G + NC + D Sbjct: 256 QGLSNEQVLKFVMD--GGYLDQPDNC----------------------------PERVTD 285 Query: 306 LLDRMLTFNPNKRITVEEALA------HPYLEQ 332 L+ FNPN R T E + HP + Sbjct: 286 LMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPE 318 >2ZMD-A nrPDB Length = 390 Score = 194 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 75/315 (23%), Positives = 124/315 (39%), Gaps = 50/315 (15%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-EIQILLRFR- 96 G Y+ L+ IG G V + +K AIK ++ E + R EI L + + Sbjct: 55 GRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 113 Query: 97 H-ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGL 154 H + +I + D + +Y+V + DL LK ++ + + +L + Sbjct: 114 HSDKIIRLYDY-----EITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 168 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 IH ++H DLKP+N LI LK+ DFG+A P+ + V Y PE Sbjct: 169 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPD-TTSVVKDSQVGAVNYMPPE 226 Query: 215 IMLNSKGY----------TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP 264 + + + D+WS+GCIL M + F I+ + Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ---------QIINQISK- 276 Query: 265 SQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 L+ II+ +P K D+L L +P +RI++ E Sbjct: 277 ----LHAIIDPNHEIEFPDIPEK--------------DLQDVLKCCLKRDPKQRISIPEL 318 Query: 325 LAHPYLEQYYDPTDE 339 LAHPY++ P ++ Sbjct: 319 LAHPYVQIQTHPVNQ 333 >5O0Y-A nrPDB Length = 579 Score = 194 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 114/298 (38%), Gaps = 49/298 (16%) Query: 53 YGMVSSAYDHVRKTRVAIKK------ISPFEHQTYCQRTLREIQILLRFRHENVIGIRDI 106 + V A+D + VA+K + + Y + RE +I H ++ + D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 107 LRASTLEAMRDVYIVQDLMET-DLYKLLKSQQL-SNDHICYFLYQILRGLKYIHSAN--V 162 T V + E DL LK +L S + QI+ LKY++ + Sbjct: 357 FSLDT----DSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPI 412 Query: 163 LHRDLKPSNLLINTT---CDLKICDFGLARIADPEH----DHTGFLTEYVATRWYRAPEI 215 +H DLKP N+L+ ++KI DFGL++I D + D ++ T WY PE Sbjct: 413 IHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPEC 472 Query: 216 MLNSK---GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 + K + +D+WSVG I + L R F SQ+D+ Sbjct: 473 FVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQ---------------SQQDILQE 517 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 + +Q P P +A + R L + RI V++ PYL Sbjct: 518 NTILKATEVQFPPK----------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 565 >3EQC-A nrPDB Length = 360 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 63/309 (20%), Positives = 125/309 (40%), Gaps = 27/309 (8%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 + ++ +G G G+V +A K I + +RE+Q+L Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 92 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYK--LLKSQQLSNDHICYFLYQILRGLKYI 157 ++G + ++ I + M+ L K+ ++ + +++GL Y+ Sbjct: 93 IVGFYGAFYSDG-----EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 147 Query: 158 -HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 ++HRD+KPSN+L+N+ ++K+CDFG++ +V TR Y +PE + Sbjct: 148 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-----SMANSFVGTRSYMSPERL 202 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + Y+ DIWS+G L EM R P + + + E Sbjct: 203 QGT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 261 Query: 277 ARNYLQSLPSKTKVAWAKLF--------PKSDS-----KALDLLDRMLTFNPNKRITVEE 323 + S+ +A +L PK S + D +++ L NP +R +++ Sbjct: 262 RPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 321 Query: 324 ALAHPYLEQ 332 + H ++++ Sbjct: 322 LMVHAFIKR 330 >5VO2-A nrPDB Length = 300 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 60/267 (22%), Positives = 115/267 (43%), Gaps = 24/267 (8%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 LQ++G GA G V H VA+KK+ + I+ L + +H N+I + Sbjct: 17 LQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD--------IKHLRKLKHPNIITFK 66 Query: 105 DILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANV 162 + + I+ + + LY++L++ + ++ + + I G+ Y+H + Sbjct: 67 GVCTQA-----PCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKI 121 Query: 163 LHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 +HRDLK N+LI +KI DFG ++ E + T + APE++ N + Sbjct: 122 IHRDLKSPNMLITYDDVVKISDFGTSK----ELSDKSTKMSFAGTVAWMAPEVIRN-EPV 176 Query: 223 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI-LGILGSPSQEDLNCIINMKARNYL 281 ++ +DIWS G +L E+L+ + + + L P + R Sbjct: 177 SEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCW 236 Query: 282 QSLPSKTKVAWAKLFPKSDSKALDLLD 308 S P + + ++ ++ D + D+L Sbjct: 237 NSKP-RNRPSFRQILLHLDIASADVLS 262 >4H1J-A nrPDB Length = 293 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 54/286 (18%), Positives = 109/286 (38%), Gaps = 46/286 (16%) Query: 46 QYIGEGAYGMVSSAY---DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 + +GEG +G V K VA+K ++ + E I+ H +++ Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVK 89 Query: 103 IRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ--LSNDHICYFLYQILRGLKYIHS 159 + I+ +I+ +L +L L+ + L + + QI + + Y+ S Sbjct: 90 LIGIIEE------EPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLES 143 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 N +HRD+ N+L+ + +K+ DFGL+R + E + +T + +W +PE + N Sbjct: 144 INCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVT-RLPIKW-MSPESI-NF 200 Query: 220 KGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKAR 278 + +T + D+W + E+LS + F D + + P + ++ Sbjct: 201 RRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYT--- 257 Query: 279 NYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 L+ R ++P+ R E Sbjct: 258 ---------------------------LMTRCWDYDPSDRPRFTEL 276 >5HLW-A nrPDB Length = 299 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 58/297 (19%), Positives = 121/297 (40%), Gaps = 16/297 (5%) Query: 19 GVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY---DHVRKTRVAIKKISP 75 + P + V+ V P + + + IG G +G V + +K A+K ++ Sbjct: 1 ALNPELVQAVQHVVIGPSSLIVHFN--EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR 58 Query: 76 FEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS 135 + L E I+ F H NV+ + I S + ++ + DL +++ Sbjct: 59 ITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRS---EGSPLVVLPYMKHGDLRNFIRN 115 Query: 136 QQLSN--DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADP 193 + + + F Q+ +G+KY+ S +HRDL N +++ +K+ DFGLAR Sbjct: 116 ETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHD 175 Query: 194 EHDHTGFLTE--YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHY 250 + ++ + +W A E + K +T D+WS G +L E+++ P +P + Sbjct: 176 KEYYSVHNKTGAKLPVKW-MALESLQTQK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNT 233 Query: 251 LDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLL 307 D ++L E + ++ + ++++L + + + Sbjct: 234 FDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP-KAEMRPSFSELVSRISAIFSTFI 289 >5TOS-A nrPDB Length = 395 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 69/326 (21%), Positives = 127/326 (38%), Gaps = 30/326 (9%) Query: 39 GPRYTQLQYIGEGAYGMVSSAY---------DHVRKTRVAIKKISPFEHQTYCQRTLREI 89 + IGEG +G V + +A+KK++ Q + + L EI Sbjct: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEI 122 Query: 90 QILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKL-LKSQQLSNDHICYFLY 148 L + H N++ + + ++ + +E L++ + L Sbjct: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 Query: 149 QILRGLKYIHS--ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 +GL ++HS V++RD+K SN+L++ + K+ DFGLAR P D + T + Sbjct: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD-GPMGDLSYVSTRVMG 241 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 T Y APE M + D++S G +L E+LS + + N + Sbjct: 242 TYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV--------- 291 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 D R L + ++ + P+ + + + L+F P R T+++ + Sbjct: 292 -DWARPYLTSKRKVLLIVDNRLD---TQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 Query: 327 HPYLEQYYDPTDEPVAEEPFTFAMEL 352 L+Q D +P P +L Sbjct: 348 A--LQQLQDNLGKPSQTNPVKDTKKL 371 >3KUL-B nrPDB Length = 325 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 60/291 (20%), Positives = 116/291 (39%), Gaps = 24/291 (8%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTR---VAIKKISPFEHQTYCQRTLREIQILLRF 95 R + IG G G V V R VAIK + + + L E I+ +F Sbjct: 48 ASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQF 107 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQ--QLSNDHICYFLYQILR 152 H N+I + ++ R IV + ME L L++ Q + + L + Sbjct: 108 DHPNIIRLEGVVTRG-----RLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGA 162 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 G++Y+ +HRDL N+L+++ K+ DFGL+R+ + + D T + A Sbjct: 163 GMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTA 222 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 PE + + ++ + D+WS G ++ E+L+ + D ++ + P+ Sbjct: 223 PEAIA-FRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPH 281 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNK-RITV 321 ++ + ++ ++++ D+ L +P R T Sbjct: 282 ALHQLMLDCWHKDRAQRPR-FSQIVSVLDA---------LIRSPESLRATA 322 >3QGY-A nrPDB Length = 286 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 114/265 (43%), Gaps = 16/265 (6%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 T +Q IG G +G+V Y + K +VAIK I E + E +++++ H ++ Sbjct: 30 TFVQEIGSGQFGLVHLGYW-LNKDKVAIKTIK--EGSMSEDDFIEEAEVMMKLSHPKLVQ 86 Query: 103 IRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ--LSNDHICYFLYQILRGLKYIHS 159 + + + +V + ME L L++Q+ + + + + G+ Y+ Sbjct: 87 LYGVCLEQA-----PICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEE 141 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 A V+HRDL N L+ +K+ DFG+ R + + T++ +W +PE+ S Sbjct: 142 ACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKF-PVKW-ASPEVFSFS 199 Query: 220 KGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKAR 278 + Y+ D+WS G ++ E+ S + + + + + I + + Sbjct: 200 R-YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMN 258 Query: 279 NYLQSLPSKTKVAWAKLFPKSDSKA 303 + + P + A+++L + A Sbjct: 259 HCWKERPE-DRPAFSRLLRQLAEIA 282 >5AMN-A nrPDB Length = 299 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 62/304 (20%), Positives = 119/304 (39%), Gaps = 33/304 (10%) Query: 28 VEMVKGQPFDVGPRYTQL-QYIGEGAYGMVSSAYDHVRKTR-----VAIKKISPFEHQTY 81 ++++ ++ + L + +GEG +G V A K R VA+K + + Sbjct: 10 FKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSE 69 Query: 82 CQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ---- 137 + L E +L + H +VI + + + IV+ L L+ + Sbjct: 70 LRDLLSEFNVLKQVNHPHVIKLYGAC----SQDGPLLLIVEYAKYGSLRGFLRESRKVGP 125 Query: 138 -------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARI 190 L+ + F +QI +G++Y+ ++HRDL N+L+ +KI DFGL+R Sbjct: 126 GYPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRD 185 Query: 191 ADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKH 249 E + + +W A E + + YT D+WS G +L E+++ +PG Sbjct: 186 VYEEDSYVKRSQGRIPVKW-MAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPGIP 243 Query: 250 YLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDR 309 N + ++ + + + P K P + DL ++ Sbjct: 244 PERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKR--------PVFADISKDL-EK 294 Query: 310 MLTF 313 M+ Sbjct: 295 MMVK 298 >5UUU-A nrPDB Length = 547 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 70/343 (20%), Positives = 125/343 (36%), Gaps = 62/343 (18%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILLRF---- 95 ++ + IG G +G V A+K + + + L E +I+L Sbjct: 200 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE-RIMLSLVSTG 258 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDL-YKLLKSQQLSNDHICYFLYQILRG 153 ++ + + + DLM DL Y L + S + ++ +I+ G Sbjct: 259 DCPFIV-----CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 313 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 L+++H+ V++RDLKP+N+L++ ++I D GLA + H V T Y AP Sbjct: 314 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-----VGTHGYMAP 368 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 E++ Y S D +S+GC+L ++L F D I Sbjct: 369 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-----------------KHEI 411 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEALAHP 328 + LP + LL+ +L + N+R+ +E P Sbjct: 412 DRMTLTMAVELPD-----------SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESP 460 Query: 329 YL----------EQYYDPTDEPVAEEPFTFAMELDDLPKERLK 361 + ++Y P P E A ++ +E K Sbjct: 461 FFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 503 >2W1I-A nrPDB Length = 326 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 58/288 (20%), Positives = 120/288 (41%), Gaps = 24/288 (8%) Query: 43 TQLQYIGEGAYGMVSSAY----DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 LQ +G+G +G V VA+KK+ + + + REI+IL +H+ Sbjct: 44 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL-QHSTEEHLRDFEREIEILKSLQHD 102 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHI--CYFLYQILRGLKY 156 N++ + + ++ ++ I++ L L L+ + DHI + QI +G++Y Sbjct: 103 NIVKYKGVCYSAGRRNLK--LIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEY 160 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 + + +HRDL N+L+ +KI DFGL ++ + ++ + ++ APE + Sbjct: 161 LGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESL 220 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 SK ++ + D+WS G +L E+ + + + ++G+ Q + ++ Sbjct: 221 TESK-FSVASDVWSFGVVLYELFT-----YIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE 274 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 LP ++ N N+R + + Sbjct: 275 LLKNNGRLPRPDGCPDEIYM---------IMTECWNNNVNQRPSFRDL 313 >3IO7-A nrPDB Length = 313 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 58/288 (20%), Positives = 120/288 (41%), Gaps = 24/288 (8%) Query: 43 TQLQYIGEGAYGMVSSAY----DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 LQ +G+G +G V VA+KK+ + + + REI+IL +H+ Sbjct: 31 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL-QHSTEEHLRDFEREIEILKSLQHD 89 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHI--CYFLYQILRGLKY 156 N++ + + ++ ++ I++ L L L+ + DHI + QI +G++Y Sbjct: 90 NIVKYKGVCYSAGRRNLK--LIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEY 147 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 + + +HRDL N+L+ +KI DFGL ++ + ++ + ++ APE + Sbjct: 148 LGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESL 207 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 SK ++ + D+WS G +L E+ + + + ++G+ Q + ++ Sbjct: 208 TESK-FSVASDVWSFGVVLYELFT-----YIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE 261 Query: 277 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 LP ++ N N+R + + Sbjct: 262 LLKNNGRLPRPDGCPDEIYM---------IMTECWNNNVNQRPSFRDL 300 >3C51-A nrPDB Length = 543 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 117/304 (38%), Gaps = 49/304 (16%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYC--QRTLREIQILLRFRHEN 99 + + +G G +G V + A KK++ + Q + E +IL + Sbjct: 187 FLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRF 246 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKL------LKSQQLSNDHICYFLYQILRG 153 ++ + A E D+ +V +M + + ++ QI+ G Sbjct: 247 IVSL-----AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSG 301 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 L+++H N+++RDLKP N+L++ +++I D GLA T Y T + AP Sbjct: 302 LEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKT---KGYAGTPGFMAP 358 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 E++L + Y S+D +++G L EM++ R F + Sbjct: 359 ELLLGEE-YDFSVDYFALGVTLYEMIAARGPFRARGE----------------------- 394 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEALAHP 328 ++ + Q + + K P S D + +L +P KR+ + + HP Sbjct: 395 KVENKELKQRVLEQAVTYPDKFSPAS----KDFCEALLQKDPEKRLGFRDGSCDGLRTHP 450 Query: 329 YLEQ 332 Sbjct: 451 LFRD 454 >2PL0-A nrPDB Length = 289 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 59/264 (22%), Positives = 118/264 (44%), Gaps = 18/264 (6%) Query: 34 QPFDVGPR-YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQIL 92 ++V ++ +G G +G V Y + T+VA+K + L E ++ Sbjct: 16 DEWEVPRETLKLVERLGAGQFGEVWMGY-YNGHTKVAVKSLKQGSMSPDA--FLAEANLM 72 Query: 93 LRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQ---QLSNDHICYFLY 148 + +H+ ++ + ++ +YI+ + ME L LK+ +L+ + + Sbjct: 73 KQLQHQRLVRLYAVVTQ------EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAA 126 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 QI G+ +I N +HRDL+ +N+L++ T KI DFGLAR+ + ++++T + Sbjct: 127 QIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE-DNEYTAREGAKFPIK 185 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQE 267 W APE + N +T D+WS G +L E+++ R +PG + + ++ + Sbjct: 186 W-TAPEAI-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPD 243 Query: 268 DLNCIINMKARNYLQSLPSKTKVA 291 + + R + P Sbjct: 244 NCPEELYQLMRLCWKERPEDRPTF 267 >3PVW-A nrPDB Length = 695 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 70/343 (20%), Positives = 125/343 (36%), Gaps = 62/343 (18%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--SPFEHQTYCQRTLREIQILLRF---- 95 ++ + IG G +G V A+K + + + L E +I+L Sbjct: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE-RIMLSLVSTG 249 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDL-YKLLKSQQLSNDHICYFLYQILRG 153 ++ + + + DLM DL Y L + S + ++ +I+ G Sbjct: 250 DCPFIV-----CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 L+++H+ V++RDLKP+N+L++ ++I D GLA + H V T Y AP Sbjct: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-----VGTHGYMAP 359 Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 E++ Y S D +S+GC+L ++L F D I Sbjct: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-----------------KHEI 402 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEALAHP 328 + LP + LL+ +L + N+R+ +E P Sbjct: 403 DRMTLTMAVELPD-----------SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESP 451 Query: 329 YL----------EQYYDPTDEPVAEEPFTFAMELDDLPKERLK 361 + ++Y P P E A ++ +E K Sbjct: 452 FFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 494 >3C1X-A nrPDB Length = 373 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 121/297 (40%), Gaps = 14/297 (4%) Query: 18 EGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY---DHVRKTRVAIKKIS 74 + P + V+ V P + + + IG G +G V + +K A+K ++ Sbjct: 69 SALNPELVQAVQHVVIGPSSLIVHFN--EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN 126 Query: 75 PFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK 134 + L E I+ F H NV+ + I S + ++ + DL ++ Sbjct: 127 RITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRS---EGSPLVVLPYMKHGDLRNFIR 183 Query: 135 SQQLSN--DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IA 191 ++ + + F Q+ +G+K++ S +HRDL N +++ +K+ DFGLAR + Sbjct: 184 NETHNPTVKDLIGFGLQVAKGMKFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMY 243 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHY 250 D E D T + A E + K +T D+WS G +L E+++ P +P + Sbjct: 244 DKEFDSVHNKTGAKLPVKWMALESLQTQK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNT 302 Query: 251 LDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLL 307 D ++L E + ++ + ++++L + + + Sbjct: 303 FDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP-KAEMRPSFSELVSRISAIFSTFI 358 >6B2Q-A nrPDB Length = 317 Score = 190 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 65/246 (26%), Positives = 104/246 (42%), Gaps = 9/246 (3%) Query: 7 QGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKT 66 G + G+ P + G + RY + I G G V A D+ Sbjct: 1 MGSSHHHHHHSSGLVPRGSLHMSPRVG--VTLSGRYRLQRLIATGGMGQVWEAVDNRLGR 58 Query: 67 RVAIKKISPF--EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDL 124 RVA+K + + +R E + H + + D + R Y+V +L Sbjct: 59 RVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMEL 118 Query: 125 METD-LYKLLKS-QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKI 182 + + L +LK +LS H L Q R L+ H+A ++HRD+KP N+LI T +KI Sbjct: 119 VNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKI 178 Query: 183 CDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 242 DFG+A+ D + + T Y APE L + + D++S+G + E +S + Sbjct: 179 TDFGIAKAVDAAPVTQTGM--VMGTAQYIAPEQALGHDA-SPASDVYSLGVVGYEAVSGK 235 Query: 243 PIFPGK 248 F G Sbjct: 236 RPFAGD 241 >3PP0-A nrPDB Length = 338 Score = 190 bits (483), Expect = 7e-49, Method: Composition-based stats. Identities = 57/271 (21%), Positives = 107/271 (39%), Gaps = 17/271 (6%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRV----AIKKISPFEHQTYCQRTLREIQILLRFRHE 98 +++ +G GA+G V V AIK + + L E ++ Sbjct: 20 RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP 79 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLK--SQQLSNDHICYFLYQILRGLK 155 V + I ST++ +V LM L ++ +L + + + QI +G+ Sbjct: 80 YVSRLLGICLTSTVQ------LVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMS 133 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 Y+ ++HRDL N+L+ + +KI DFGLAR+ D + V +W A E Sbjct: 134 YLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKW-MALES 192 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 274 +L + +T D+WS G + E+++ + G + + + P + Sbjct: 193 ILRRR-FTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVY 251 Query: 275 MKARNYLQSLPSKTKVAWAKLFPKSDSKALD 305 M + S+ + + +L + A D Sbjct: 252 MIMVKCWM-IDSECRPRFRELVSEFSRMARD 281 >5UIU-A nrPDB Length = 323 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 60/216 (27%), Positives = 97/216 (44%), Gaps = 16/216 (7%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS---PFEHQTYCQRTLREIQI 91 FD P +GEG +G+V Y V T VA+KK++ + Q+ +EI++ Sbjct: 42 NFDERPISVGGNKMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKV 99 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS----QQLSNDHICYFL 147 + + +HEN++ + + VY+ L L LS C Sbjct: 100 MAKCQHENLVELLGFSSDGDDLCLVYVYM----PNGSLLDRLSCLDGTPPLSWHMRCKIA 155 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 G+ ++H + +HRD+K +N+L++ KI DFGLAR A + T + V T Sbjct: 156 QGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLAR-ASEKFAQTVMTSRIVGT 214 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRP 243 Y APE + T DI+S G +L E+++ P Sbjct: 215 TAYMAPEALRGE--ITPKSDIYSFGVVLLEIITGLP 248 >4X3F-A nrPDB Length = 337 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 61/216 (28%), Positives = 97/216 (44%), Gaps = 7/216 (3%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF--EHQTYCQRTLREIQILLR 94 + RY + I G G V A D+ RVA+K + + +R E + Sbjct: 9 TLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAM 68 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLKS-QQLSNDHICYFLYQILR 152 H + + D + R Y+V +L+ + L +LK +LS H L Q R Sbjct: 69 LNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGR 128 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 L+ H+A ++HRD+KP N+LI T +KI DFG+A+ D + + T Y A Sbjct: 129 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGM--VMGTAQYIA 186 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 248 PE L + + D++S+G + E +S + F G Sbjct: 187 PEQALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 221 >4OW8-A nrPDB Length = 283 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 61/216 (28%), Positives = 97/216 (44%), Gaps = 7/216 (3%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF--EHQTYCQRTLREIQILLR 94 + RY + I G G V A D+ RVA+K + + +R E + Sbjct: 8 TLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAM 67 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-LYKLLKS-QQLSNDHICYFLYQILR 152 H + + D + R Y+V +L+ + L +LK +LS H L Q R Sbjct: 68 LNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGR 127 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 L+ H+A ++HRD+KP N+LI T +KI DFG+A+ D + + T Y A Sbjct: 128 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGM--VMGTAQYIA 185 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 248 PE L + + D++S+G + E +S + F G Sbjct: 186 PEQALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 220 >3QUP-A nrPDB Length = 323 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 56/295 (18%), Positives = 115/295 (38%), Gaps = 46/295 (15%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRK---TRVAIKKIS-PFEHQTYCQRTLREIQILLRF 95 ++T + +G+G +G V A +VA+K + + + LRE + F Sbjct: 23 QQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEF 82 Query: 96 RHENVIGIRDI-LRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ-------LSNDHICYF 146 H +V + + LR+ + ++ M DL+ L + + L + F Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRF 142 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 + I G++Y+ S N +HRDL N ++ + + DFGL+R + + Sbjct: 143 MVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLP 202 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPS 265 +W A E + ++ YT D+W+ G + E+++ + + G + N+++G Sbjct: 203 VKW-LALESLADN-LYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIG------ 254 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT 320 K P+ + DL+ + + +P +R + Sbjct: 255 ------------------------GNRLKQPPECMEEVYDLMYQCWSADPKQRPS 285 >4R7H-A nrPDB Length = 343 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 56/263 (21%), Positives = 103/263 (39%), Gaps = 40/263 (15%) Query: 18 EGVGPGVPGEVEMVKGQPFDVGPR-YTQLQYIGEGAYGMVSSAYDHVRKT-----RVAIK 71 EG ++ + ++ + +G GA+G V A +VA+K Sbjct: 27 EGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVK 86 Query: 72 KISPFEHQTYCQRTLREIQILLRF-RHENVIGIRDILRASTLEAMRDVYIVQDLME-TDL 129 + H + + E++I+ +HEN++ + V ++ + DL Sbjct: 87 MLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGG-----PVLVITEYCTYGDL 141 Query: 130 YKLLKS------------------------QQLSNDHICYFLYQILRGLKYIHSANVLHR 165 L+ + L + +F Q+ +G+ ++ S N +HR Sbjct: 142 LNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHR 201 Query: 166 DLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 225 D+ N+L+ KI DFGLAR + ++ + +W APE + +S YT Sbjct: 202 DVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKW-MAPESIFDS-VYTVQ 259 Query: 226 IDIWSVGCILAEMLS-NRPIFPG 247 D+WS G +L E+ S +PG Sbjct: 260 SDVWSYGILLWEIFSLGLNPYPG 282 >4M7I-A nrPDB Length = 299 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 62/286 (21%), Positives = 117/286 (40%), Gaps = 25/286 (8%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + +Q +G G +G+V A + V AIK+I + ++ +RE++ L + H ++ Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV 66 Query: 102 GIRD-ILRASTLEAMR------DVYIVQDLMETDLYKLLKSQQLSNDHI-----CYFLYQ 149 + L +T E ++ +YI L + K + + + + + Q Sbjct: 67 RYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQ 126 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFL-------- 201 I ++++HS ++HRDLKPSN+ +K+ DFGL D + + L Sbjct: 127 IAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYAR 186 Query: 202 -TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI 260 T V T+ Y +PE + + Y+ +DI+S+G IL E+L F + + + Sbjct: 187 HTGQVGTKLYMSPEQI-HGNSYSHKVDIFSLGLILFELL---YPFSTQMERVRTLTDVRN 242 Query: 261 LGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDL 306 L P + S + + + + LD Sbjct: 243 LKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDF 288 >1K9A-A nrPDB Length = 450 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 67/293 (22%), Positives = 113/293 (38%), Gaps = 54/293 (18%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 LQ IG+G +G V R +VA+K I + Q L E ++ + RH N++ Sbjct: 196 KLLQTIGKGEFGDVMLG--DYRGNKVAVKCIK---NDATAQAFLAEASVMTQLRHSNLVQ 250 Query: 103 IRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ---LSNDHICYFLYQILRGLKYIH 158 + ++ +E +YIV + M + L L+S+ L D + F + ++Y+ Sbjct: 251 LLGVI----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 N +HRDL N+L++ K+ DFGL + A D T + +W APE + Sbjct: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-----TGKLPVKW-TAPEAL-R 359 Query: 219 SKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 K ++ D+WS G +L E+ S R +P D + + Sbjct: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRV-------------------E 400 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA---LAH 327 + Y P D++ + R T + L H Sbjct: 401 KGYKMDAPD-----------GCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 >4WUA-A nrPDB Length = 401 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 85/377 (22%), Positives = 141/377 (37%), Gaps = 98/377 (25%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH- 97 RY ++ +G G + V ++D K VA+K + EH Y + L EI++L R+ Sbjct: 40 NGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEH--YTETALDEIRLLKSVRNS 97 Query: 98 -EN------VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL---KSQQLSNDHICYFL 147 N V+ + D + S + + +V +++ L K + Q L + + Sbjct: 98 DPNDPNREMVVQLLDDFKISGVNG-THICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKII 156 Query: 148 YQILRGLKYIHSA-NVLHRDLKPSNLLIN------------------------------- 175 Q+L+GL Y+H+ ++H D+KP N+L++ Sbjct: 157 QQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVST 216 Query: 176 ------------------TTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 +KI D G A TE + TR YR+ E+++ Sbjct: 217 APATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKH------FTEDIQTRQYRSLEVLI 270 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKH------YLDQLNHILGILGSPSQE---- 267 S GY DIWS C+ E+ + +F D + I+ +LG ++ Sbjct: 271 GS-GYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVA 329 Query: 268 ------------DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 315 DL I +K + L K W++ + + D L ML P Sbjct: 330 GKYSKEFFTKKGDLKHITKLKPWGLFEVLVEK--YEWSQ---EEAAGFTDFLLPMLELIP 384 Query: 316 NKRITVEEALAHPYLEQ 332 KR T E L HP+L Sbjct: 385 EKRATAAECLRHPWLNS 401 >5U6B-A nrPDB Length = 307 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 59/311 (18%), Positives = 118/311 (37%), Gaps = 46/311 (14%) Query: 44 QLQYIGEGAYGMVSSAYDHVRKT--RVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENV 100 + +GEG +G V + + +VA+K + ++ + L E + F H NV Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 101 IGIRDIL-RASTLEAMRDVYIVQDLM-ETDLYKLLKSQQL-------SNDHICYFLYQIL 151 + + + + S E+ ++ M DL+ L +L + F+ I Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 G++Y+ + +HRDL N ++N + + DFGL++ + + +W Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKW-I 205 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 A E + + + YT D+WS G + E+ + + +PG + +++ G+ ++ + Sbjct: 206 AIESLAD-RVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQ--GNRLKQPAD 262 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAH-PY 329 C+ + A L+ R NP R + E Sbjct: 263 CLDGLYA----------------------------LMSRCWELNPQDRPSFTELREDLEN 294 Query: 330 LEQYYDPTDEP 340 + P EP Sbjct: 295 TLKALPPAQEP 305 >6J5U-C nrPDB Length = 426 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 69/323 (21%), Positives = 128/323 (39%), Gaps = 28/323 (8%) Query: 14 PRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVR--------- 64 RTEG P + + + Q +GEG +G V + Sbjct: 58 TLRTEGEILSSPNLKAFTFNELKNATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGS 117 Query: 65 KTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDL 124 VA+K++ P Q + + L E+ L + H N++ + + ++ + Sbjct: 118 GIVVAVKQLKPEGFQGHKE-WLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGS 176 Query: 125 METDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLLINTTCDLKI 182 +E L++ +Q L+ +GL ++H A V++RD K +N+L++ + K+ Sbjct: 177 LENHLFRR-GAQPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKL 235 Query: 183 CDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 242 DFGLA+ A P D+T T+ + T Y APE + + T D++S G +L E++S R Sbjct: 236 SDFGLAK-AGPTGDNTHVSTKVIGTHGYAAPEYVATGRL-TAKSDVYSFGVVLLELISGR 293 Query: 243 PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSK 302 + ++ + + +P D + + P K Sbjct: 294 RAMDNSNGGNEYSLVDWA--TPYLGDKRKLFRIMDTKLGGQYPQKGAFT----------- 340 Query: 303 ALDLLDRMLTFNPNKRITVEEAL 325 A +L + L + R + E L Sbjct: 341 AANLALQCLNPDAKLRPKMSEVL 363 >4OTD-A nrPDB Length = 341 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 69/345 (20%), Positives = 126/345 (36%), Gaps = 53/345 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFR--- 96 + L +G G +G V + AIK + + + + + E +IL Sbjct: 14 FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAG 73 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDL-METDLYKLLKSQQLSNDHICYFLYQILRGLK 155 H ++ + + V V + DL + S S ++ ++ GL+ Sbjct: 74 HPFLVNLFGCF-----QTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQ 128 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 ++H +++RDLK NLL++T +KI DFGL + D T + T + APE+ Sbjct: 129 FLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTS---TFCGTPEFLAPEV 185 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + ++ YT+++D W +G +L EML FPG + + I+ Sbjct: 186 LTDT-SYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIV----------------- 227 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEALAHPYL 330 N P ++A+ ++ R+L NP +R+ E+ P+ Sbjct: 228 ---NDEVRYPRF-----------LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF 273 Query: 331 EQ-YYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPG 374 ++ PF + E E P Sbjct: 274 RTLGWEALLARRLPPPFVPTLSGR-TDVSNFDEEFTGEAPTLSPP 317 >5FM2-A nrPDB Length = 355 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 64/336 (19%), Positives = 121/336 (36%), Gaps = 47/336 (13%) Query: 10 GGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQL-QYIGEGAYGMVSSAYDHVRKTR- 67 G P ++++ ++ + L + +GEG +G V A K R Sbjct: 33 GARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRA 92 Query: 68 ----VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQD 123 VA+K + + + L E +L + H +VI + + + IV+ Sbjct: 93 GYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGAC----SQDGPLLLIVEY 148 Query: 124 LMETDLYKLLKSQQ-------------------------LSNDHICYFLYQILRGLKYIH 158 L L+ + L+ + F +QI +G++Y+ Sbjct: 149 AKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLA 208 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 ++HRDL N+L+ +KI DFGL+R E + + +W A E + + Sbjct: 209 EMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKW-MAIESLFD 267 Query: 219 SKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 YT D+WS G +L E+++ +PG N + ++ + + Sbjct: 268 H-IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLM 326 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTF 313 + P K P + DL ++M+ Sbjct: 327 LQCWKQEPDKR--------PVFADISKDL-EKMMVK 353 >4C59-A nrPDB Length = 340 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 70/332 (21%), Positives = 125/332 (37%), Gaps = 57/332 (17%) Query: 18 EGVGPGVPGEVEMVK-GQPFDVGP-RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP 75 G G G + GQ ++G R + + EG + V A D A+K++ Sbjct: 3 PGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLS 62 Query: 76 FEHQTYCQRTLREIQILLRFR-HENVIGI---RDILRASTLEAMRDVYIVQDLMETDLYK 131 E + ++E+ + + H N++ I + + + ++ +L + L + Sbjct: 63 NEEEKNR-AIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVE 121 Query: 132 LLK----SQQLSNDHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLLINTTCDLKICDF 185 LK LS D + YQ R ++++H ++HRDLK NLL++ +K+CDF Sbjct: 122 FLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDF 181 Query: 186 GLARIADPEHDHTGFLTEYV---------ATRWYRAPEIMLNSKGY--TKSIDIWSVGCI 234 G A D++ T YR PEI+ + + DIW++GCI Sbjct: 182 GSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCI 241 Query: 235 LAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAK 294 L + + F ++ N S+P Sbjct: 242 LYLLCFRQHPF------------------------EDGAKLRIVNGKYSIPPHDTQY--T 275 Query: 295 LFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 +F L+ ML NP +R+++ E + Sbjct: 276 VFHS-------LIRAMLQVNPEERLSIAEVVH 300 >5GRN-A nrPDB Length = 356 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 63/285 (22%), Positives = 110/285 (38%), Gaps = 43/285 (15%) Query: 44 QLQYIGEGAYGMVSSAYDHVRKT-----RVAIKKISPFEHQTYCQRTLREIQILLRFR-H 97 + +G GA+G V + +VA+K + P + Q + E++I+ H Sbjct: 50 LGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPH 109 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ------------------- 137 N++ + S +YI+ + DL L + Sbjct: 110 LNIVNLLGACTKSG-----PIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNL 164 Query: 138 --------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR 189 L+ + F YQ+ RG++++ S N +HRDL N+L+ +KICDFGLAR Sbjct: 165 LSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLAR 224 Query: 190 IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGK 248 + ++ + ++ +W APE + ++ YT D+WS G +L E+ S +PG Sbjct: 225 DIMHDSNYVSKGSTFLPVKW-MAPESIFDN-LYTTLSDVWSYGILLWEIFSLGGTPYPGM 282 Query: 249 HYLDQ-LNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAW 292 N I + + S P K + Sbjct: 283 MVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFY 327 >4HVI-A nrPDB Length = 314 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 58/280 (20%), Positives = 117/280 (41%), Gaps = 27/280 (9%) Query: 48 IGEGAYGMVSSAY----DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGI 103 +G+G +G V VA+K++ + REIQIL + ++ Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQL-QHSGPDQQRDFQREIQILKALHSDFIVKY 76 Query: 104 RDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ--LSNDHICYFLYQILRGLKYIHSAN 161 R + +++R +++ L L L+ + L + + QI +G++Y+ S Sbjct: 77 RGVSYGPGRQSLR--LVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRR 134 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKG 221 +HRDL N+L+ + +KI DFGLA++ + D+ + ++ APE + ++ Sbjct: 135 CVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDN-I 193 Query: 222 YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK-ARNY 280 +++ D+WS G +L E+ + + K SPS E L + + + Sbjct: 194 FSRQSDVWSFGVVLYELFT----YCDKSC------------SPSAEFLRMMGSERDVPAL 237 Query: 281 LQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT 320 + L + P ++ +L+ +P R + Sbjct: 238 SRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPS 277 >5U6C-A nrPDB Length = 315 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 50/261 (19%), Positives = 102/261 (39%), Gaps = 15/261 (5%) Query: 44 QLQYIGEGAYGMVSSA---YDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHEN 99 + +GEG +G V + +VA+K + Q + L E + F H N Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPN 99 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQL-------SNDHICYFLYQIL 151 V+ + + + + + ++ M+ DL+ L +L + F+ I Sbjct: 100 VMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIA 159 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 G++Y+ + N LHRDL N ++ + + DFGL++ + + +W Sbjct: 160 LGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKW-I 218 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 A E + + + YT D+W+ G + E+ + +PG + +++L ED Sbjct: 219 AIESLAD-RVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCL 277 Query: 271 CIINMKARNYLQSLPSKTKVA 291 + + ++ P Sbjct: 278 DELYEIMYSCWRTDPLDRPTF 298 >4LRM-A nrPDB Length = 334 Score = 188 bits (477), Expect = 5e-48, Method: Composition-based stats. Identities = 58/289 (20%), Positives = 119/289 (41%), Gaps = 21/289 (7%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRV----AIKKISPFEHQTYCQRTLREIQILLRFRH 97 + +++ +G GA+G V +V AIK++ + L E ++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN 80 Query: 98 E---NVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ--LSNDHICYFLYQIL 151 +V + I ST++ ++ LM L ++ + + + ++ + QI Sbjct: 81 PGNPHVCRLLGICLTSTVQ------LITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA 134 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 +G+ Y+ ++HRDL N+L+ T +KI DFGLA++ E V +W Sbjct: 135 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW-M 193 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 A E +L+ + YT D+WS G + E+++ + G + + + P Sbjct: 194 ALESILH-RIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT 252 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI 319 + M + + ++ + +L + A D R L ++R+ Sbjct: 253 IDVYMIMVKCWM-IDADSRPKFRELIIEFSKMARD-PQRYLVIQGDERM 299 >1BYG-A nrPDB Length = 278 Score = 187 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 61/245 (24%), Positives = 106/245 (43%), Gaps = 21/245 (8%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 LQ IG+G +G V R +VA+K I + Q L E ++ + RH N++ Sbjct: 24 KLLQTIGKGEFGDVMLG--DYRGNKVAVKCIK---NDATAQAFLAEASVMTQLRHSNLVQ 78 Query: 103 IRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ---LSNDHICYFLYQILRGLKYIH 158 + ++ +E +YIV + M + L L+S+ L D + F + ++Y+ Sbjct: 79 LLGVI----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 134 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN 218 N +HRDL N+L++ K+ DFGL + A D T + +W APE + Sbjct: 135 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-----TGKLPVKW-TAPEAL-R 187 Query: 219 SKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 K ++ D+WS G +L E+ S R +P D + + + + + Sbjct: 188 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 247 Query: 278 RNYLQ 282 +N Sbjct: 248 KNCWH 252 >3LLT-A nrPDB Length = 360 Score = 187 bits (476), Expect = 6e-48, Method: Composition-based stats. Identities = 69/335 (20%), Positives = 131/335 (39%), Gaps = 56/335 (16%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + ++ +G+G +G V K A+K + + Y + E IL + +++++ Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNI--KKYTRSAKIEADILKKIQNDDIN 94 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ---QLSNDHICYFLYQILRGLKYIH 158 + + ++ + + LY+++ + I + +IL+ L Y+ Sbjct: 95 NNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLR 154 Query: 159 SANVLHRDLKPSNLLINT-------------------------TCDLKICDFGLARIADP 193 ++ H DLKP N+L++ + +K+ DFG A Sbjct: 155 KMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSD 214 Query: 194 EHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQ 253 H + TR YRAPE++LN G+ S D+WS GC+LAE+ + +F +++ Sbjct: 215 YH------GSIINTRQYRAPEVILN-LGWDVSSDMWSFGCVLAELYTGSLLFRTHEHMEH 267 Query: 254 LNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDS------------ 301 L + I+ + L Y+ + K+AW + +S Sbjct: 268 LAMMESIIQPIPKNMLYEATKTNGSKYVNK--DELKLAWPENASSINSIKHVKKCLPLYK 325 Query: 302 -----KALDLLDRMLTFNPNKRITVEEALAHPYLE 331 D L +L +P R + E L H +LE Sbjct: 326 IIKHELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >1S9I-A nrPDB Length = 354 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 66/314 (21%), Positives = 128/314 (40%), Gaps = 33/314 (10%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 + ++ +G G G+V+ +A K I + +RE+Q+L Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 75 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLK-SQQLSNDHICYFLYQILRGLKYI 157 ++G + ++ I + M+ L ++LK ++++ + + +LRGL Y+ Sbjct: 76 IVGFYGAFYSDG-----EISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYL 130 Query: 158 HSAN-VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 + ++HRD+KPSN+L+N+ ++K+CDFG++ +V TR Y APE + Sbjct: 131 REKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-----SMANSFVGTRSYMAPERL 185 Query: 217 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 276 + Y+ DIWS+G L E+ R P +L I G +E I+ + Sbjct: 186 QGT-HYSVQSDIWSMGLSLVELAVGRYPIP-PPDAKELEAIFGRPVVDGEEGEPHSISPR 243 Query: 277 ARNY----------------LQSLPSKTKVAWAKLFPK--SDSKALDLLDRMLTFNPNKR 318 R + L P + +++ L NP +R Sbjct: 244 PRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAER 303 Query: 319 ITVEEALAHPYLEQ 332 ++ H ++++ Sbjct: 304 ADLKMLTNHTFIKR 317 >1FVR-A nrPDB Length = 327 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 112/305 (36%), Gaps = 62/305 (20%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRV--AIKKISPFEHQTYCQRTLREIQILLRF-RHEN 99 IGEG +G V A R+ AIK++ + + + E+++L + H N Sbjct: 28 KFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 87 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ-----------------LSND 141 +I + +Y+ + +L L+ + LS+ Sbjct: 88 IINLLGACEHRG-----YLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQ 142 Query: 142 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFL 201 + +F + RG+ Y+ +HRDL N+L+ KI DFGL+R + + Sbjct: 143 QLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKT 199 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGI 260 + RW A E + N YT + D+WS G +L E++S + G + + Sbjct: 200 MGRLPVRW-MAIESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQ- 256 Query: 261 LGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT 320 G ++ LNC D + DL+ + P +R + Sbjct: 257 -GYRLEKPLNC----------------------------DDEVYDLMRQCWREKPYERPS 287 Query: 321 VEEAL 325 + L Sbjct: 288 FAQIL 292 >3SXS-A nrPDB Length = 268 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 53/267 (19%), Positives = 101/267 (37%), Gaps = 15/267 (5%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 T L+ +G G +G+V + VA+K I E +E Q +++ H ++ Sbjct: 11 TLLKELGSGQFGVVKLGKWKG-QYDVAVKMIK--EGSMSEDEFFQEAQTMMKLSHPKLVK 67 Query: 103 IRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ--LSNDHICYFLYQILRGLKYIHS 159 + +YIV + + L L+S L + Y + G+ ++ S Sbjct: 68 FYGVCSKEY-----PIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLES 122 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 +HRDL N L++ +K+ DFG+ R + + T++ +W APE+ Sbjct: 123 HQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKF-PVKW-SAPEVFHYF 180 Query: 220 KGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKAR 278 K Y+ D+W+ G ++ E+ S + + + + + + I Sbjct: 181 K-YSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMY 239 Query: 279 NYLQSLPSKTKVAWAKLFPKSDSKALD 305 + LP K L + D Sbjct: 240 SCWHELPEKRPTFQQLLSSIEPLREKD 266 >4Y93-A nrPDB Length = 446 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 52/253 (20%), Positives = 105/253 (41%), Gaps = 16/253 (6%) Query: 36 FDVGPR-YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 +++ P+ T L+ +G G +G+V + VAIK I E + E ++++ Sbjct: 183 WEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIK--EGSMSEDEFIEEAKVMMN 239 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLK--SQQLSNDHICYFLYQIL 151 HE ++ + + R ++I+ + M L L+ + + + Sbjct: 240 LSHEKLVQLYGVCTKQ-----RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVC 294 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 ++Y+ S LHRDL N L+N +K+ DFG+ R + ++T +W Sbjct: 295 EAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYV-LDDEYTSSTGSKFPVKW-A 352 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 +PE+++ SK ++ DIW+ G ++ E+ S + + + HI L P + Sbjct: 353 SPEVLMYSK-FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLAS 411 Query: 271 CIINMKARNYLQS 283 + + Sbjct: 412 ERVYAIMYSCWHE 424 >4YHJ-A nrPDB Length = 584 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 64/317 (20%), Positives = 117/317 (36%), Gaps = 49/317 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT--LREIQILLRFRHEN 99 + + +G+G +G V + A KK+ + L E +IL + + Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRF 246 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKL----LKSQQLSNDHICYFLYQILRGLK 155 V+ + A E + +V +M K L + ++ ++ GL+ Sbjct: 247 VVSL-----AYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLE 301 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 + +++RDLKP N+L++ ++I D GLA + V T Y APE+ Sbjct: 302 DLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ----RVRGRVGTVGYMAPEV 357 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + N++ YT S D W +GC++ EM+ F Sbjct: 358 V-NNEKYTFSPDWWGLGCLIYEMIQGHSPF---------------------------KKY 389 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEALAHPYL 330 K + + + + K + K A + +LT NP+KR+ HP Sbjct: 390 KEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVF 449 Query: 331 EQ-YYDPTDEPVAEEPF 346 + + + + E PF Sbjct: 450 KDINFRRLEANMLEPPF 466 >3MDY-A nrPDB Length = 337 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 75/300 (25%), Positives = 123/300 (41%), Gaps = 29/300 (9%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 + + ++ IG+G YG V +VA+K E ++ + T EI + R Sbjct: 34 TIAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRET--EIYQTVLMR 89 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSNDHICYFLYQILRGLK 155 HEN++G T + +Y++ D E LY LKS L + Y + GL Sbjct: 90 HENILGFIAADIKGT-GSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLC 148 Query: 156 YIH--------SANVLHRDLKPSNLLINTTCDLKICDFGLA-RIADPEHDHTGFLTEYVA 206 ++H + HRDLK N+L+ I D GLA + ++ V Sbjct: 149 HLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVG 208 Query: 207 TRWYRAPEIM---LNSKGYTKS--IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 261 T+ Y PE++ LN + D++S G IL E ++ R + G QL + + Sbjct: 209 TKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWE-VARRCVSGGIVEEYQLPYHDLVP 267 Query: 262 GSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 321 PS ED+ I+ +K S P++ W+ + + L+ NP R+T Sbjct: 268 SDPSYEDMREIVCIK--KLRPSFPNR----WSSD--ECLRQMGKLMTECWAHNPASRLTA 319 >1AD5-A nrPDB Length = 438 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 117/269 (43%), Gaps = 28/269 (10%) Query: 29 EMVKGQPFDVGPRYTQLQY-IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR 87 + + +++ +L+ +G G +G V A + + T+VA+K + P + L Sbjct: 170 KPWEKDAWEIPRESLKLEKKLGAGQFGEVWMAT-YNKHTKVAVKTMKPGSMS--VEAFLA 226 Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQLS---NDHI 143 E ++ +H+ ++ + ++ +YI+ + M + L LKS + S + Sbjct: 227 EANVMKTLQHDKLVKLHAVV------TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKL 280 Query: 144 CYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE 203 F QI G+ +I N +HRDL+ +N+L++ + KI DFGLAR+ Sbjct: 281 IDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARV-----------GA 329 Query: 204 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILG 262 +W APE + N +T D+WS G +L E+++ R +PG + + + Sbjct: 330 KFPIKW-TAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYR 387 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTKVA 291 P E+ + ++ P + Sbjct: 388 MPRPENCPEELYNIMMRCWKNRPEERPTF 416 >6FER-A nrPDB Length = 309 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 60/310 (19%), Positives = 115/310 (37%), Gaps = 56/310 (18%) Query: 43 TQLQYIGEGAYGMVSSA--------YDH--------VRKTRVAIKKISPFEHQTYCQRTL 86 T + +GEG +G V D + VA+K + ++ L Sbjct: 12 TFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFL 71 Query: 87 REIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ-------- 137 +EI+I+ R + N+I + + + ++ + ME DL + L + Sbjct: 72 KEIKIMSRLKDPNIIHLLAVCITDD-----PLCMITEYMENGDLNQFLSRHEPPNSSSSD 126 Query: 138 ---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPE 194 +S ++ + QI G+KY+ S N +HRDL N L+ +KI DFG++R Sbjct: 127 VRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSG 186 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 + + RW + E +L K +T + D+W+ G L E + F + QL Sbjct: 187 DYYRIQGRAVLPIRW-MSWESILLGK-FTTASDVWAFGVTLWETFT----FCQEQPYSQL 240 Query: 255 NHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFN 314 + ++ + Q+ + + ++ L+ + Sbjct: 241 S---------DEQVIENTGEFFRDQGRQTYLPQPAICPDSVYK--------LMLSCWRRD 283 Query: 315 PNKRITVEEA 324 R + +E Sbjct: 284 TKNRPSFQEI 293 >4XI2-A nrPDB Length = 446 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 54/251 (21%), Positives = 100/251 (39%), Gaps = 15/251 (5%) Query: 15 RRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS 74 P + G T L+ +G G +G+V + VAIK I Sbjct: 162 YPVSKQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIR 220 Query: 75 PFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLL 133 E + E ++++ HE ++ + + R ++I+ + M L L Sbjct: 221 --EGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQ-----RPIFIITEYMANGCLLNYL 273 Query: 134 K--SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIA 191 + + + + ++Y+ S LHRDL N L+N +K+ DFGL+R Sbjct: 274 REMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV 333 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHY 250 + ++T + RW PE+++ SK ++ DIW+ G ++ E+ S + + Sbjct: 334 -LDDEYTSSVGSKFPVRW-SPPEVLMYSK-FSSKSDIWAFGVLMWEIYSLGKMPYERFTN 390 Query: 251 LDQLNHILGIL 261 + HI L Sbjct: 391 SETAEHIAQGL 401 >4CRS-A nrPDB Length = 341 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 69/343 (20%), Positives = 127/343 (37%), Gaps = 60/343 (17%) Query: 50 EGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQI---LLRFRHENVIGIR 104 G +G V A AIK + + + + E +I + RH ++ + Sbjct: 22 RGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLF 81 Query: 105 DILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 + V V + DL + + S ++ ++ GL+Y+H ++ Sbjct: 82 ACF-----QTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIV 136 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 223 +RDLK NLL++T +KI DFGL + D T + T + APE++ + YT Sbjct: 137 YRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTS---TFCGTPEFLAPEVLTET-SYT 192 Query: 224 KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQS 283 +++D W +G ++ EML FPG + + I+ N Sbjct: 193 RAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIV--------------------NDEVR 232 Query: 284 LPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI-----TVEEALAHPYLE--QYYDP 336 P ++A+ ++ R+L NP +R+ E+ HP+ + Sbjct: 233 YPRF-----------LSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSAL 281 Query: 337 TDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP 379 D+ V +D+ F + + +L P Sbjct: 282 MDKKVKPPFIPTIRGREDVSN-------FDDEFTSEAPILTPP 317 >6E4F-A nrPDB Length = 290 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 53/253 (20%), Positives = 105/253 (41%), Gaps = 16/253 (6%) Query: 36 FDVGPR-YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 +++ P+ T L+ +G G +G+V + VAIK I E + E ++++ Sbjct: 26 WEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIK--EGSMSEDEFIEEAKVMMN 82 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLK--SQQLSNDHICYFLYQIL 151 HE ++ + + R ++I+ + M L L+ + + + Sbjct: 83 LSHEKLVQLYGVCTKQ-----RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVC 137 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 ++Y+ S LHRDL N L+N +K+ DFGL+R + ++T + RW Sbjct: 138 EAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV-LDDEYTSSVGSKFPVRW-S 195 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 PE+++ SK ++ DIW+ G ++ E+ S + + + HI L + Sbjct: 196 PPEVLMYSK-FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLAS 254 Query: 271 CIINMKARNYLQS 283 + + Sbjct: 255 EKVYTIMYSCWHE 267 >3PLS-A nrPDB Length = 298 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 55/254 (21%), Positives = 106/254 (41%), Gaps = 13/254 (5%) Query: 46 QYIGEGAYGMVSSAYDH---VRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 + IG+G +G+V + + AIK +S + LRE ++ H NV+ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLA 86 Query: 103 IRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSN--DHICYFLYQILRGLKYIHSA 160 + I+ E + V + + DL + ++S Q + + F Q+ RG++Y+ Sbjct: 87 LIGIMLPP--EGLPHVLLP-YMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQ 143 Query: 161 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHT--GFLTEYVATRWYRAPEIMLN 218 +HRDL N +++ + +K+ DFGLAR ++ + +W A E + Sbjct: 144 KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKW-TALESLQT 202 Query: 219 SKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 + +T D+WS G +L E+L+ P + D + + P E + Sbjct: 203 YR-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVM 261 Query: 278 RNYLQSLPSKTKVA 291 + ++ P+ Sbjct: 262 QQCWEADPAVRPTF 275 >5HVK-A nrPDB Length = 315 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 114/300 (38%), Gaps = 49/300 (16%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 + +G+G +G + +K++ F+ +T L+E++++ H NV+ Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQR-TFLKEVKVMRCLEHPNVLKFI 77 Query: 105 DILRASTLEAMRDVYIVQDLMETDLYKLLKSQ--QLSNDHICYFLYQILRGLKYIHSANV 162 +L R +I + + L ++KS Q F I G+ Y+HS N+ Sbjct: 78 GVLYK----DKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNI 133 Query: 163 LHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLT-----------EYVATRWYR 211 +HR+L N L+ ++ + DFGLAR+ E L V ++ Sbjct: 134 IHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWM 193 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 APE++ N + Y + +D++S G +L E+ I + P Sbjct: 194 APEMI-NGRSYDEKVDVFSFGIVLCEI------------------IGRVNADPDYLPRTM 234 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + R +L FP + R +P KR + + L H +LE Sbjct: 235 DFGLNVRGFLDRYCPPNCPP--SFFPITV--------RCCDLDPEKRPSFVK-LEH-WLE 282 >1U59-A nrPDB Length = 287 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 53/242 (21%), Positives = 104/242 (42%), Gaps = 15/242 (6%) Query: 47 YIGEGAYGMVSSAYDHVRKTR--VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 +G G +G V +RK + VAIK + + + +RE QI+ + + ++ + Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 76 Query: 105 DILRASTLEAMRDVYIVQDLMETD-LYKLL--KSQQLSNDHICYFLYQILRGLKYIHSAN 161 + +A + +V ++ L+K L K +++ ++ L+Q+ G+KY+ N Sbjct: 77 GVCQAEA------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 130 Query: 162 VLHRDLKPSNLLINTTCDLKICDFGLARIADPEH-DHTGFLTEYVATRWYRAPEIMLNSK 220 +HRDL N+L+ KI DFGL++ + +T +WY APE + N + Sbjct: 131 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECI-NFR 188 Query: 221 GYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN 279 ++ D+WS G + E LS + + + + I + + + Sbjct: 189 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 248 Query: 280 YL 281 Sbjct: 249 CW 250 >1PY5-A nrPDB Length = 326 Score = 185 bits (469), Expect = 4e-47, Method: Composition-based stats. Identities = 72/320 (22%), Positives = 120/320 (37%), Gaps = 35/320 (10%) Query: 17 TEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF 76 T G G G+P V+ + + IG+G +G V VA+K S Sbjct: 12 TSGSGSGLPLLVQRT------IARTIVLQESIGKGRFGEVWRGKWR--GEEVAVKIFSSR 63 Query: 77 EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKS 135 E +++ + EI + RHEN++G +++V D E L+ L Sbjct: 64 EERSWFREA--EIYQTVMLRHENILGFIAA-DNKDNGTWTQLWLVSDYHEHGSLFDYLNR 120 Query: 136 QQLSNDHICYFLYQILRGLKYIH--------SANVLHRDLKPSNLLINTTCDLKICDFGL 187 ++ + + GL ++H + HRDLK N+L+ I D GL Sbjct: 121 YTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGL 180 Query: 188 ARIADPEHDHTGFL-TEYVATRWYRAPEIM---LNSKGYT--KSIDIWSVGCILAEMLSN 241 A D D V T+ Y APE++ +N K + K DI+++G + E+ Sbjct: 181 AVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARR 240 Query: 242 RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDS 301 I G H QL + + PS E++ ++ Q L W ++ Sbjct: 241 CSI-GGIHEDYQLPYYDLVPSDPSVEEMRKVVCE------QKLRPNIPNRWQSC--EALR 291 Query: 302 KALDLLDRMLTFNPNKRITV 321 ++ N R+T Sbjct: 292 VMAKIMRECWYANGAARLTA 311 >2A1A-B nrPDB Length = 284 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 65/303 (21%), Positives = 118/303 (38%), Gaps = 60/303 (19%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 G + +++ IG G +G V A + IK++ ++ RE++ L + H Sbjct: 10 GMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK-----YNNEKAEREVKALAKLDHV 64 Query: 99 NVIGIRDIL-----------RASTLEAMRDVYIVQDLME-TDLYKLLKSQQ---LSNDHI 143 N++ + S+ + ++I + + L + ++ ++ L Sbjct: 65 NIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLA 124 Query: 144 CYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE 203 QI +G+ YIHS +++RDLKPSN+ + T +KI DFGL + T Sbjct: 125 LELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKR----TR 180 Query: 204 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS 263 T Y +PE + +S+ Y K +D++++G ILAE+L H D Sbjct: 181 SKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL---------HVCDTAFETSKFFTD 230 Query: 264 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEE 323 ++ I + K + LL ++L+ P R E Sbjct: 231 LRDGIISDIFDKKEKT--------------------------LLQKLLSKKPEDRPNTSE 264 Query: 324 ALA 326 L Sbjct: 265 ILR 267 >6CTH-A nrPDB Length = 309 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 56/212 (26%), Positives = 99/212 (46%), Gaps = 15/212 (7%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 V + +GEG +G V + T +A+KK+S Q + E++I+ R R Sbjct: 12 KVTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYA-SEVKIISRLR 70 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ--LSNDHICYFLYQILRG 153 H+N++ + ++ +V + M L + + L+ + + + Sbjct: 71 HKNLVKLIGWCHERG-----ELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASA 125 Query: 154 LKYIHS---ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY 210 L Y+H VLHRD+K SN++++++ + K+ DFGLAR+ D H T T Y Sbjct: 126 LLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVD--HAKGLKKTLLAGTVGY 183 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 242 APE + + K +K D++S G + E+ S R Sbjct: 184 MAPECLSSGKA-SKESDVYSFGVVALEIASGR 214 >3ZBF-A nrPDB Length = 322 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 56/268 (20%), Positives = 102/268 (38%), Gaps = 28/268 (10%) Query: 47 YIGEGAYGMVSSAYDH------VRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 100 +G GA+G V + +VA+K + L+E ++ +F H N+ Sbjct: 40 LLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNI 99 Query: 101 IGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQL--------SNDHICYFLYQIL 151 + + + + YI+ +LME DL L+ ++ + + I Sbjct: 100 LKQLGVCLLNEPQ-----YIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDIS 154 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCD-----LKICDFGLARIADPEHDHTGFLTEYVA 206 +G Y+ + +HRDL N L++ +KI DFGLAR + + Sbjct: 155 KGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLP 214 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPS 265 RW APE +++ +T D+WS G ++ E+L+ +P LD LN++ Sbjct: 215 VRW-MAPESLMDG-IFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 272 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWA 293 + + P + Sbjct: 273 PRNCPDDLWNLMTQCWAQEPDQRPTFHR 300 >5TUR-A nrPDB Length = 404 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 64/311 (20%), Positives = 115/311 (36%), Gaps = 58/311 (18%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ-----RTLREIQILLR 94 +Y +G G +G V S VAIK + + + R E+ +L + Sbjct: 127 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 186 Query: 95 FRH--ENVIGIRDILRASTLEAMRDVYIVQDLMET--DLYKLL-KSQQLSNDHICYFLYQ 149 VI + D ++ + E DL+ + + L + F +Q Sbjct: 187 VSSGFSGVIRLLDWFERPDS-----FVLILERPEPVQDLFDFITERGALQEELARSFFWQ 241 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLIN-TTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 +L +++ H+ VLHRD+K N+LI+ +LK+ DFG + T++ TR Sbjct: 242 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-----TVYTDFDGTR 296 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 Y PE + + + +S +WS+G +L +M+ F +E Sbjct: 297 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-----------------EEI 339 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 328 + + + R S+ L+ L P+ R T EE HP Sbjct: 340 IRGQVFFRQR--------------------VSSECQHLIRWCLALRPSDRPTFEEIQNHP 379 Query: 329 YLEQYYDPTDE 339 +++ P + Sbjct: 380 WMQDVLLPQET 390 >3BGP-A nrPDB Length = 333 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 64/311 (20%), Positives = 115/311 (36%), Gaps = 58/311 (18%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ-----RTLREIQILLR 94 +Y +G G +G V S VAIK + + + R E+ +L + Sbjct: 56 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 115 Query: 95 FRH--ENVIGIRDILRASTLEAMRDVYIVQDLMET--DLYKLL-KSQQLSNDHICYFLYQ 149 VI + D ++ + E DL+ + + L + F +Q Sbjct: 116 VSSGFSGVIRLLDWFERPDS-----FVLILERPEPVQDLFDFITERGALQEELARSFFWQ 170 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLIN-TTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208 +L +++ H+ VLHRD+K N+LI+ +LK+ DFG + T++ TR Sbjct: 171 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-----TVYTDFDGTR 225 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 Y PE + + + +S +WS+G +L +M+ F +E Sbjct: 226 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-----------------EEI 268 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 328 + + + R S+ L+ L P+ R T EE HP Sbjct: 269 IRGQVFFRQR--------------------VSSECQHLIRWCLALRPSDRPTFEEIQNHP 308 Query: 329 YLEQYYDPTDE 339 +++ P + Sbjct: 309 WMQDVLLPQET 319 >3I81-A nrPDB Length = 315 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 57/288 (19%), Positives = 111/288 (38%), Gaps = 32/288 (11%) Query: 24 VPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDH-----VRKTRVAIKKISPFEH 78 VP E E+ + + T + +G+G++GMV +TRVAIK ++ Sbjct: 9 VPDEWEVAR-------EKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAAS 61 Query: 79 QTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ 137 L E ++ F +V+ + ++ + ++ +LM DL L+S + Sbjct: 62 MRERIEFLNEASVMKEFNCHHVVRLLGVVSQG-----QPTLVIMELMTRGDLKSYLRSLR 116 Query: 138 --------LSNDHICYFLY---QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFG 186 L+ + + +I G+ Y+++ +HRDL N ++ +KI DFG Sbjct: 117 PEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFG 176 Query: 187 LARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIF 245 + R + + RW +PE + + +T D+WS G +L E+ + + Sbjct: 177 MTRDIYETDYYRKGGKGLLPVRW-MSPESLKDG-VFTTYSDVWSFGVVLWEIATLAEQPY 234 Query: 246 PGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWA 293 G L ++ ++ ++ R Q P Sbjct: 235 QGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE 282 >2OZO-A nrPDB Length = 613 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 56/276 (20%), Positives = 110/276 (39%), Gaps = 16/276 (5%) Query: 14 PRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQY-IGEGAYGMVSSAYDHVRKTR--VAI 70 P T E+ + F +G G +G V +RK + VAI Sbjct: 309 PMDTSVFESPFSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAI 368 Query: 71 KKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD-L 129 K + + + +RE QI+ + + ++ + + +A + +V ++ L Sbjct: 369 KVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA------LMLVMEMAGGGPL 422 Query: 130 YKLL--KSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGL 187 +K L K +++ ++ L+Q+ G+KY+ N +HR+L N+L+ KI DFGL Sbjct: 423 HKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYAKISDFGL 482 Query: 188 ARIADPEH-DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIF 245 ++ + +T +WY APE + N + ++ D+WS G + E LS + + Sbjct: 483 SKALGADDSYYTARSAGKWPLKWY-APECI-NFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 Query: 246 PGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYL 281 + + I + + + Sbjct: 541 KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCW 576 >3Q4U-A nrPDB Length = 301 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 70/309 (22%), Positives = 114/309 (36%), Gaps = 47/309 (15%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 V T L+ +G+G YG V VA+K S + +++ + T E+ + R Sbjct: 5 TVARDITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRET--ELYNTVMLR 60 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKY 156 HEN++G S + + I LY L+ L + I GL + Sbjct: 61 HENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAH 120 Query: 157 IH--------SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVAT 207 +H + HRDLK N+L+ I D GLA + + V T Sbjct: 121 LHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGT 180 Query: 208 RWYRAPEIMLNSKGYT-----KSIDIWSVGCILAEMLSN----------RPIFPGKHYLD 252 + Y APE++ + K +DIW+ G +L E+ +P F Sbjct: 181 KRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDV---- 236 Query: 253 QLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLT 312 + PS ED+ ++ + Q P+ ++ P S A L+ Sbjct: 237 -------VPNDPSFEDMRKVVCVD-----QQRPNIPNRWFSD--PTLTSLAK-LMKECWY 281 Query: 313 FNPNKRITV 321 NP+ R+T Sbjct: 282 QNPSARLTA 290 >2RIO-A nrPDB Length = 434 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 81/315 (25%), Positives = 136/315 (43%), Gaps = 66/315 (20%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR-HENVIGIR 104 + +G G+ G V + VA+K++ +C L EI++L H NVI Sbjct: 21 KILGYGSSGTVVF-QGSFQGRPVAVKRM----LIDFCDIALMEIKLLTESDDHPNVIRYY 75 Query: 105 DILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHIC--------YFLYQILRGLKY 156 + R +YI +L +L L++S+ +S++++ L QI G+ + Sbjct: 76 -----CSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAH 130 Query: 157 IHSANVLHRDLKPSNLLIN-------------TTCDLKICDFGLARIADPEHDH-TGFLT 202 +HS ++HRDLKP N+L++ + I DFGL + D L Sbjct: 131 LHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLN 190 Query: 203 EYVATRWYRAPEIMLNS------KGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLN 255 T +RAPE++ S + T+SIDI+S+GC+ +LS + F G Y + N Sbjct: 191 NPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF-GDKYSRESN 249 Query: 256 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 315 I GI S +++ C+ + ++A DL+ +M+ +P Sbjct: 250 IIRGIF---SLDEMKCLHDRSLI----------------------AEATDLISQMIDHDP 284 Query: 316 NKRITVEEALAHPYL 330 KR T + L HP Sbjct: 285 LKRPTAMKVLRHPLF 299 >4HZS-A nrPDB Length = 341 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 57/259 (22%), Positives = 98/259 (37%), Gaps = 17/259 (6%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTR---VAIKKISP--FEHQTYCQRTLREIQILLRFRH 97 L+ +G+G++G+V + VA+K + P +RE+ + H Sbjct: 15 RLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDH 74 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ--LSNDHICYFLYQILRGL 154 N+I + ++ ++ +V +L L L+ Q + + Q+ G+ Sbjct: 75 RNLIRLYGVVLTPPMK------MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 128 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 Y+ S +HRDL NLL+ T +KI DFGL R DH + APE Sbjct: 129 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 188 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGS-PSQEDLNCI 272 + ++ ++ + D W G L EM + + + G + L+ I P ED Sbjct: 189 SL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 247 Query: 273 INMKARNYLQSLPSKTKVA 291 I P Sbjct: 248 IYNVMVQCWAHKPEDRPTF 266 >4RC3-A nrPDB Length = 289 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 66/322 (20%), Positives = 120/322 (37%), Gaps = 60/322 (18%) Query: 29 EMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQ----- 83 M + +P + +Y +G G +G V S VAIK + + + Sbjct: 3 HMKEKEPLE--SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 60 Query: 84 RTLREIQILLRFRH--ENVIGIRDILRASTLEAMRDVYIVQDLMET--DLYKLL-KSQQL 138 R E+ +L + VI + D ++ + E DL+ + + L Sbjct: 61 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDS-----FVLILERPEPVQDLFDFITERGAL 115 Query: 139 SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN-TTCDLKICDFGLARIADPEHDH 197 + F +Q+L +++ H+ VLHRD+K N+LI+ +LK+ DFG + Sbjct: 116 QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD---- 171 Query: 198 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 257 T++ TR Y PE + + + +S +WS+G +L +M+ F Sbjct: 172 -TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD--------- 221 Query: 258 LGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNK 317 +E + + + R S+ L+ L P+ Sbjct: 222 --------EEIIRGQVFFRQR--------------------VSSECQHLIRWCLALRPSD 253 Query: 318 RITVEEALAHPYLEQYYDPTDE 339 R T EE HP+++ P + Sbjct: 254 RPTFEEIQNHPWMQDVLLPQET 275 >3MY0-A nrPDB Length = 305 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 114/299 (38%), Gaps = 27/299 (9%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 V + ++ +G+G YG V H VA+K S + Q++ + T EI + R Sbjct: 5 TVARQVALVECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFRET--EIYNTVLLR 60 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKY 156 H+N++G S + + I LY L+ Q L GL + Sbjct: 61 HDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAH 120 Query: 157 IH--------SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVAT 207 +H + HRD K N+L+ + I D GLA + D+ V T Sbjct: 121 LHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGT 180 Query: 208 RWYRAPEIMLNSKGYT-----KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILG 262 + Y APE++ K DIW+ G +L E+ R I G + + Sbjct: 181 KRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA-RRTIVNGIVEDYRPPFYDVVPN 239 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 321 PS ED+ ++ + + ++P++ P A ++ NP+ R+T Sbjct: 240 DPSFEDMKKVVCVDQQT--PTIPNRLAAD-----PVLSGLAQ-MMRECWYPNPSARLTA 290 >4PL5-B nrPDB Length = 435 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 79/322 (24%), Positives = 130/322 (40%), Gaps = 52/322 (16%) Query: 22 PGVPGEVEMVKGQPFDVGP-RYTQLQYIGEGAYGM-VSSAYDHVRKTRVAIKKISPFEHQ 79 P + + E + + VG + +G GA G V VA+K+I P Sbjct: 8 PSLEQDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKGM--FDNRDVAVKRILPECFS 65 Query: 80 TYCQRTLREIQILLRFR-HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQL 138 RE+Q+L H NVI T + + YI +L L + ++ + Sbjct: 66 F----ADREVQLLRESDEHPNVIRYF-----CTEKDRQFQYIAIELCAATLQEYVEQKDF 116 Query: 139 SND--HICYFLYQILRGLKYIHSANVLHRDLKPSNLLI---NTTCDLK--ICDFGLARIA 191 ++ L+Q GL ++HS N++HRDLKP N+L+ N +K I DFGL + Sbjct: 117 AHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKL 176 Query: 192 DPEHDHTGFLTEYVATRWYRAPEIMLN--SKGYTKSIDIWSVGCILAEMLS-NRPIFPGK 248 + T + APE++ T ++DI+S GC+ ++S F GK Sbjct: 177 AVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GK 235 Query: 249 HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLD 308 Q N +LG L+C + K D A +L++ Sbjct: 236 SLQRQANILLGACN------LDCFHSDK---------------------HEDVIARELIE 268 Query: 309 RMLTFNPNKRITVEEALAHPYL 330 +M+ +P +R + + L HP+ Sbjct: 269 KMIAMDPQQRPSAKHVLKHPFF 290 >1U54-B nrPDB Length = 291 Score = 180 bits (458), Expect = 7e-46, Method: Composition-based stats. Identities = 57/259 (22%), Positives = 98/259 (37%), Gaps = 17/259 (6%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTR---VAIKKISP--FEHQTYCQRTLREIQILLRFRH 97 L+ +G+G++G+V + VA+K + P +RE+ + H Sbjct: 21 RLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDH 80 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ--LSNDHICYFLYQILRGL 154 N+I + ++ ++ +V +L L L+ Q + + Q+ G+ Sbjct: 81 RNLIRLYGVVLTPPMK------MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 134 Query: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 214 Y+ S +HRDL NLL+ T +KI DFGL R DH + APE Sbjct: 135 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 194 Query: 215 IMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGS-PSQEDLNCI 272 + ++ ++ + D W G L EM + + + G + L+ I P ED Sbjct: 195 SL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 253 Query: 273 INMKARNYLQSLPSKTKVA 291 I P Sbjct: 254 IYNVMVQCWAHKPEDRPTF 272 >6HV0-A nrPDB Length = 416 Score = 180 bits (457), Expect = 8e-46, Method: Composition-based stats. Identities = 77/297 (25%), Positives = 121/297 (40%), Gaps = 51/297 (17%) Query: 46 QYIGEGAYGM-VSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR-HENVIGI 103 +G GA G V VA+K+I P RE+Q+L H NVI Sbjct: 14 DVLGHGAEGTIVYRG--MFDNRDVAVKRILPECFSF----ADREVQLLRESDEHPNVIRY 67 Query: 104 RDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSND--HICYFLYQILRGLKYIHSAN 161 T + + YI +L L + ++ + ++ L Q GL ++HS N Sbjct: 68 F-----CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLN 122 Query: 162 VLHRDLKPSNLLI---NTTCDLK--ICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 ++HRDLKP N+LI N +K I DFGL + + T + APE++ Sbjct: 123 IVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEML 182 Query: 217 LN--SKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 + T ++DI+S GC+ ++S F GK Q N +LG L+C+ Sbjct: 183 SEDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACS------LDCLH 235 Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 330 K D A +L+++M+ +P KR + + L HP+ Sbjct: 236 PEK---------------------HEDVIARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >3UIU-A nrPDB Length = 306 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 65/316 (20%), Positives = 118/316 (37%), Gaps = 73/316 (23%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 G + +++ IG G +G V A + I+++ ++ RE++ L + H Sbjct: 11 GMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVK-----YNNEKAEREVKALAKLDHV 65 Query: 99 NVIGIRDIL------------------------RASTLEAMRDVYIVQDLME-TDLYKLL 133 N++ + S+ + ++I + + L + + Sbjct: 66 NIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWI 125 Query: 134 KSQQ---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARI 190 + ++ L QI +G+ YIHS ++HRDLKPSN+ + T +KI DFGL Sbjct: 126 EKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTS 185 Query: 191 ADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHY 250 + T T Y +PE + +S+ Y K +D++++G ILAE+L H Sbjct: 186 LKNDGKR----TRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL---------HV 231 Query: 251 LDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRM 310 D ++ I + K + LL ++ Sbjct: 232 CDTAFETSKFFTDLRDGIISDIFDKKEKT--------------------------LLQKL 265 Query: 311 LTFNPNKRITVEEALA 326 L+ P R E L Sbjct: 266 LSKKPEDRPNTSEILR 281 >4TPT-A nrPDB Length = 303 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 50/213 (23%), Positives = 86/213 (40%), Gaps = 24/213 (11%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 + +G+G +G + +K++ + +T + L E++++ H NV+ Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQ-KTFLTEVKVMRSLDHPNVLKFI 63 Query: 105 DILRASTLEAMRDVYIVQDLMETDLYKLLKS-QQLSNDHICYFLYQILRGLKYIHSANVL 163 +L + YI L L+S F I G+ Y+HS ++ Sbjct: 64 GVLYKDKKLNLLTEYI----EGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCII 119 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLT-----------------EYVA 206 HRDL N LI + + DFGL+R+ E V Sbjct: 120 HRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVG 179 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 239 ++ APE MLN K Y +++DI+S G +L E++ Sbjct: 180 NPYWMAPE-MLNGKSYDETVDIFSFGIVLCEII 211 >5B2L-A nrPDB Length = 324 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 111/310 (35%), Gaps = 51/310 (16%) Query: 39 GPRY-------TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQI 91 G RY L +G G G V +A+K++ ++ +R L ++ + Sbjct: 9 GQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDV 68 Query: 92 -LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS--QQLSNDHICYFLY 148 L ++ T DV+I +LM T KL K + + Sbjct: 69 VLKSHDCPYIVQCFG-----TFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTV 123 Query: 149 QILRGLKYI-HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 I++ L Y+ V+HRD+KPSN+L++ +K+CDFG++ + T Sbjct: 124 AIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVD----SKAKTRSAGC 179 Query: 208 RWYRAPEIML----NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS 263 Y APE + Y D+WS+G L E+ + + FP K+ + +L Sbjct: 180 AAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQ--FPYKNCKTDFEVLTKVL-- 235 Query: 264 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEE 323 + + + LT + KR + Sbjct: 236 -----------------------QEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNK 272 Query: 324 ALAHPYLEQY 333 L H ++++Y Sbjct: 273 LLEHSFIKRY 282 >4YFF-A nrPDB Length = 311 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 54/256 (21%), Positives = 98/256 (38%), Gaps = 18/256 (7%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFRHENVIGI 103 + IG G++G V VAIK+ ++ RE+ IL + H VI Sbjct: 48 EIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQF 105 Query: 104 RDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ--LSNDHICYFLYQILRGLKYIHS-- 159 + + Q + L+ LL Q+ L + +G++Y+H+ Sbjct: 106 VGACLNDPSQF---AIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLT 162 Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219 ++HRDL N+L+ + DFG +R + +T+ + APE+ Sbjct: 163 QPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDN--MTKQPGNLRWMAPEVFTQC 220 Query: 220 KGYTKSIDIWSVGCILAEMLSNRPIF----PGKHYLDQ-LNHILGILGSPSQEDLNCIIN 274 YT D++S L E+L+ F P D +HI +G + ++ ++ Sbjct: 221 TRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLI 280 Query: 275 MKARNYLQSLPSKTKV 290 + P ++V Sbjct: 281 RGWNACPEGRPEFSEV 296 >5VD3-A nrPDB Length = 311 Score = 177 bits (449), Expect = 6e-45, Method: Composition-based stats. Identities = 69/328 (21%), Positives = 113/328 (34%), Gaps = 56/328 (17%) Query: 9 GGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRV 68 G E ++ G P P + +L +G G+YG V Sbjct: 35 GEASETLQSPGYDPSRPESF---------FQQSFQRLSRLGHGSYGEVFKVRSKEDGRLY 85 Query: 69 AIKK-ISPFEHQTYCQRTLREIQILLRF-RHENVIGIRDILRASTLEAMRDVYIVQDLME 126 A+K+ +SPF R L E+ + +H + + E +Y+ +L Sbjct: 86 AVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRL-----EQAWEEGGILYLQTELCG 140 Query: 127 TDLYKLLKSQQ--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICD 184 L + ++ L + +L L L ++HS ++H D+KP+N+ + K+ D Sbjct: 141 PSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGD 200 Query: 185 FGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPI 244 FGL E G Y APE++ S Y + D++S+G + E+ N + Sbjct: 201 FGL----LVELGTAGAGEVQEGDPRYMAPELLQGS--YGTAADVFSLGLTILEVACNMEL 254 Query: 245 FPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKAL 304 G QL + S+ Sbjct: 255 PHGGEGWQQLRQ--------------------------------GYLPPEFTAGLSSELR 282 Query: 305 DLLDRMLTFNPNKRITVEEALAHPYLEQ 332 +L ML +P R T E LA P L Q Sbjct: 283 SVLVMMLEPDPKLRATAEALLALPVLRQ 310 >5WNL-A nrPDB Length = 342 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 77/339 (22%), Positives = 137/339 (40%), Gaps = 51/339 (15%) Query: 26 GEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQR- 84 G + + FD G + + +G G +G V KT +AIK SP H +R Sbjct: 7 GRWALGLLRTFDAGE-FAGWEKVGSGGFGQVYKVRHVHWKTWLAIK-CSPSLHVDDRERM 64 Query: 85 -TLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSNDH 142 L E + + + ++ + I + V +V + ME L KLL S+ L D Sbjct: 65 ELLEEAKKMEMAKFRYILPVYGICQ-------EPVGLVMEYMETGSLEKLLASEPLPWDL 117 Query: 143 ICYFLYQILRGLKYIH--SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGF 200 +++ G+ ++H S +LH +LKP+N+L++ +KI DFGLA+ H H Sbjct: 118 RFRIVHETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLS 177 Query: 201 LTEYVATRWYRAPEIM-LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 259 + T Y PE + S+ + D++S ++ +L+ + F + + HI+ Sbjct: 178 MDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKN---ILHIMM 234 Query: 260 ILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI 319 + + +L I + P++ + + L+ R +P R Sbjct: 235 KVVKGHRPELPPICRPR--------------------PRACASLIGLMQRCWHADPQVRP 274 Query: 320 TVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKE 358 T +E E + E+P E+ DL E Sbjct: 275 TFQEI----------TSETEDLCEKP---DEEVKDLAHE 300 >2WTK-B nrPDB Length = 373 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 69/344 (20%), Positives = 118/344 (34%), Gaps = 34/344 (9%) Query: 39 GPRYTQLQYIGEGAYG--MVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-EIQILLRF 95 G Y L IG+G V+ A V +++I+ L+ E+ + F Sbjct: 8 GGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLF 67 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQL----SNDHICYFLYQIL 151 H N++ R T A ++++V M K L + I Y L +L Sbjct: 68 NHPNIVPYRA-----TFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVL 122 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCDLKICDF--GLARIADPEHDHT--GFLTEYVAT 207 + L YIH +HR +K S++LI+ + + L+ I+ + F V Sbjct: 123 KALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKV 182 Query: 208 RWYRAPEIMLNS-KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG------- 259 + +PE++ + +GY DI+SVG E+ + F L L Sbjct: 183 LPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLL 242 Query: 260 ILGSPSQEDLNCIINMKARN--------YLQSLPSKTKVAWAKLFPKSDSKALDLLDRML 311 + E+L + N PS +++ L Sbjct: 243 DTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCL 302 Query: 312 TFNPNKRITVEEALAHPYLEQYYDPTDEPVAE--EPFTFAMELD 353 NP+ R + L H + +Q E + E P T + Sbjct: 303 QRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFE 346 >3UIM-A nrPDB Length = 326 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 58/285 (20%), Positives = 118/285 (41%), Gaps = 15/285 (5%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHEN 99 ++ +G G +G V T VA+K++ Q + E++++ H N Sbjct: 30 DNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRN 88 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIH 158 ++ +R T + Y+ + + L + +SQ L RGL Y+H Sbjct: 89 LLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLH 148 Query: 159 SA---NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 ++HRD+K +N+L++ + + DFGLA++ D + T T T + APE Sbjct: 149 DHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMD--YKDTHVTTAVRGTIGHIAPEY 206 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFP-----GKHYLDQLNHILGILGSPSQEDLN 270 + K ++ D++ G +L E+++ + F + L+ + G+L E L Sbjct: 207 LSTGKS-SEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKLEALV 265 Query: 271 CI-INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFN 314 + + ++ + + + P K +++ RML + Sbjct: 266 DVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVV-RMLEGD 309 >5LPZ-A nrPDB Length = 332 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 59/294 (20%), Positives = 121/294 (41%), Gaps = 32/294 (10%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + IG G +G V A + VAIKK+ Q + + E++ + + +H N++ Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDRE-FMAEMETIGKIKHRNLV 76 Query: 102 GIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ-----LSNDHICYFLYQILRGLK 155 + + +V + M+ L +L + L+ RGL Sbjct: 77 PLLGYCKVGDER-----LLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLA 131 Query: 156 YIHSA---NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 ++H +++HRD+K SN+L++ + ++ DFG+AR+ H T T Y Sbjct: 132 FLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVST-LAGTPGYVP 190 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE + + TK D++S G +L E+L+ + + D N+++G + ++ ++ + Sbjct: 191 PEYYQSFRCSTKG-DVYSYGVVLLELLTGKRPTDSPDFGD--NNLVGWVKQHAKLRISDV 247 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 + + +L + D +A +R T+ + +A Sbjct: 248 FDPELMKEDPALEIELLQHLKVAVACLDDRAW------------RRPTMVQVMA 289 >5LPV-A nrPDB Length = 296 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 59/294 (20%), Positives = 121/294 (41%), Gaps = 32/294 (10%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + IG G +G V A + VAIKK+ Q + + E++ + + +H N++ Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDRE-FMAEMETIGKIKHRNLV 76 Query: 102 GIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ-----LSNDHICYFLYQILRGLK 155 + + +V + M+ L +L + L+ RGL Sbjct: 77 PLLGYCKVGDER-----LLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLA 131 Query: 156 YIHSA---NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 ++H +++HRD+K SN+L++ + ++ DFG+AR+ H T T Y Sbjct: 132 FLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVST-LAGTPGYVP 190 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE + + TK D++S G +L E+L+ + + D N+++G + ++ ++ + Sbjct: 191 PEYYQSFRCSTKG-DVYSYGVVLLELLTGKRPTDSPDFGD--NNLVGWVKQHAKLRISDV 247 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 + + +L + D +A +R T+ + +A Sbjct: 248 FDPELMKEDPALEIELLQHLKVAVACLDDRAW------------RRPTMVQVMA 289 >4X7Q-B nrPDB Length = 312 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 67/306 (21%), Positives = 113/306 (36%), Gaps = 66/306 (21%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI--------SPFEHQTYCQRTLREIQILL 93 Y +G+G +G V + + + +VAIK I SP C E+ +L Sbjct: 33 YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCP---LEVALLW 89 Query: 94 RFR----HENVIGIRDILRASTLEAMRDVYIVQD--LMETDLYKLL-KSQQLSNDHICYF 146 + H VI + D E +V + L DL+ + + L F Sbjct: 90 KVGAGGGHPGVIRLLDWF-----ETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCF 144 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLIN-TTCDLKICDFGLARIADPEHDHTGFLTEYV 205 Q++ +++ HS V+HRD+K N+LI+ K+ DFG + E T++ Sbjct: 145 FGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPY-----TDFD 199 Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 TR Y PE + + + +WS+G +L +M+ F Sbjct: 200 GTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF-----------------ERD 242 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 QE L ++ A L+ R L P+ R ++EE L Sbjct: 243 QEILEAELHFPA--------------------HVSPDCCALIRRCLAPKPSSRPSLEEIL 282 Query: 326 AHPYLE 331 P+++ Sbjct: 283 LDPWMQ 288 >2BUJ-A nrPDB Length = 317 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 70/309 (22%), Positives = 112/309 (36%), Gaps = 48/309 (15%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 Y +Q +GEG + V A+K+I E Q + RE + F H Sbjct: 28 NKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHE-QQDREEAQREADMHRLFNHP 86 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL-----KSQQLSNDHICYFLYQILRG 153 N++ + ++ L+ + K L+ D I + L I RG Sbjct: 87 NILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRG 146 Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGL---ARIADPEHDHTGFLTEYVA---T 207 L+ IH+ HRDLKP+N+L+ + D G A I L ++ A T Sbjct: 147 LEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCT 206 Query: 208 RWYRAPEIMLNSKGY--TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 YRAPE+ + D+WS+GC+L M+ + D + + Sbjct: 207 ISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY------DMVFQKGDSVALAV 260 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVE--- 322 Q L+ + P+ S LL+ M+T +P++R + Sbjct: 261 QNQLSIPQS----------------------PRHSSALWQLLNSMMTVDPHQRPHIPLLL 298 Query: 323 ---EALAHP 328 EAL P Sbjct: 299 SQLEALQPP 307 >2H34-A nrPDB Length = 309 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 71/251 (28%), Positives = 105/251 (41%), Gaps = 15/251 (5%) Query: 19 GVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF-- 76 G + G E +G F Y + +G G G V A D VR+ VA+K +S Sbjct: 16 PRGSHMDGTAESREGTQF---GPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLS 72 Query: 77 EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKS 135 + R RE + R + +V+ I D E +Y+ L+ DL +L+ Sbjct: 73 SDPVFRTRMQREARTAGRLQEPHVVPIHDF-----GEIDGQLYVDMRLINGVDLAAMLRR 127 Query: 136 Q-QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPE 194 Q L+ + QI L H+A HRD+KP N+L++ + DFG+A E Sbjct: 128 QGPLAPPRAVAIVRQIGSALDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDE 187 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 L V T +Y APE S T DI+++ C+L E L+ P + G Sbjct: 188 K--LTQLGNTVGTLYYMAPERFSESHA-TYRADIYALTCVLYECLTGSPPYQGDQLSVMG 244 Query: 255 NHILGILGSPS 265 HI + PS Sbjct: 245 AHINQAIPRPS 255 >3SOC-A nrPDB Length = 322 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 63/293 (21%), Positives = 112/293 (38%), Gaps = 27/293 (9%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 L+ G +G V A + VA+K + Q++ E+ L +HEN++ Sbjct: 27 QLLEVKARGRFGCVWKAQ--LLNEYVAVKIFPIQDKQSWQNEY--EVYSLPGMKHENILQ 82 Query: 103 IRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS--- 159 + T + I + L LK+ +S + +C+ + RGL Y+H Sbjct: 83 FIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIP 142 Query: 160 -------ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 + HRD+K N+L+ I DFGLA + G V TR Y A Sbjct: 143 GLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEA-GKSAGDTHGQVGTRRYMA 201 Query: 213 PEIMLNSKGYTK----SIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268 PE++ + + + ID++++G +L E+ S G L I PS ED Sbjct: 202 PEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLED 261 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 321 + ++ K + + W K + + ++ + R++ Sbjct: 262 MQEVVVHKKKR------PVLRDYWQK--HAGMAMLCETIEECWDHDAEARLSA 306 >3ZZW-A nrPDB Length = 289 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 98/272 (36%), Gaps = 29/272 (10%) Query: 43 TQLQYIGEGAYGMVSSAYD-----HVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 ++ +GE +G V + + VAIK + + E + R +H Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQH 71 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK-----------------SQQLSN 140 NV+ + ++ + I DL++ L L Sbjct: 72 PNVVCLLGVVTKDQPLS----MIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEP 127 Query: 141 DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGF 200 + + QI G++Y+ S +V+H+DL N+L+ ++KI D GL R + Sbjct: 128 PDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLL 187 Query: 201 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILG 259 + RW APE ++ K ++ DIWS G +L E+ S + G D + I Sbjct: 188 GNSLLPIRW-MAPEAIMYGK-FSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRN 245 Query: 260 ILGSPSQEDLNCIINMKARNYLQSLPSKTKVA 291 P +D + PS+ Sbjct: 246 RQVLPCPDDCPAWVYALMIECWNEFPSRRPRF 277 >4NEU-A nrPDB Length = 333 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 65/319 (20%), Positives = 128/319 (40%), Gaps = 49/319 (15%) Query: 50 EGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFRHENVIGIRDILR 108 G +G VS + + + +K + + + L E +++ R RH V+ + ++ Sbjct: 34 SGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVII 92 Query: 109 ASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSNDHIC-YFLYQILRGLKYIHSANVLHRD 166 + +V + ME +L +LK++ + + + +I+ G+ Y+H V+H+D Sbjct: 93 EEGKYS-----LVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKD 147 Query: 167 LKPSNLLINTTCDLKICDFGLA------RIADPEHDH----TGFLTEYVATRWYRAPEIM 216 LKP N+L++ +KI D GLA ++ + EH+ G + T +Y APE + Sbjct: 148 LKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHL 207 Query: 217 LN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + + T+ D++S +L + +N+ + QL + P +D+ Sbjct: 208 NDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYC-- 265 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT---VEEALAHPYLEQ 332 + + L+ NP R T +EE YL Q Sbjct: 266 ------------------------PREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQ 301 Query: 333 YYDPTDEPVAEEPFTFAME 351 + +E V ++ E Sbjct: 302 LEESVEEDVKSLKKEYSNE 320 >3AOX-A nrPDB Length = 344 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 51/267 (19%), Positives = 99/267 (37%), Gaps = 23/267 (8%) Query: 40 PRYTQLQYIGEGAYGMVSSAY-----DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 T ++ +G GA+G V + +VA+K + + L E I+ + Sbjct: 47 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK 106 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ--------LSNDHICYF 146 F H+N++ + +L+++ +++ + DL L+ + L+ + + Sbjct: 107 FNHQNIVRCIGV----SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHV 162 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTC---DLKICDFGLARIADPEHDHTGFLTE 203 I G +Y+ + +HRD+ N L+ KI DFG+AR + Sbjct: 163 ARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCA 222 Query: 204 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILG 262 + +W PE + +T D WS G +L E+ S +P K + L + Sbjct: 223 MLPVKW-MPPEAFMEG-IFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGR 280 Query: 263 SPSQEDLNCIINMKARNYLQSLPSKTK 289 ++ + Q P Sbjct: 281 MDPPKNCPGPVYRIMTQCWQHQPEDRP 307 >4JLC-A nrPDB Length = 657 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 45/219 (20%), Positives = 84/219 (38%), Gaps = 21/219 (9%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + +G+GA V A+K + +RE ++L + H+N++ Sbjct: 10 WLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 69 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLK----SQQLSNDHICYFLYQILRGLKYI 157 + I +T V I++ LY +L+ + L L ++ G+ ++ Sbjct: 70 KLFAIEEETT--TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 127 Query: 158 HSANVLHRDLKPSNLL--INTTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 ++HRD+KP N++ I K+ DFG AR + + T Y P Sbjct: 128 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY----GTEEYLHP 183 Query: 214 EIML-------NSKGYTKSIDIWSVGCILAEMLSNRPIF 245 ++ + K Y ++D+WSVG + F Sbjct: 184 DMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPF 222 >4Y83-A nrPDB Length = 332 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 114/296 (38%), Gaps = 42/296 (14%) Query: 35 PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 P+ + R +I GA+G V A D K R+A K I + + +++I Sbjct: 68 PWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKP------SDVEIQAC 121 Query: 95 FRHENVIGIRDILRASTLEAMRDVYIVQDLMETD--LYKLLKSQQLSNDHICYFLYQILR 152 FRHEN+ + + V++ + E L KL + I + +L+ Sbjct: 122 FRHENIAELYGAVLWG-----ETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLK 176 Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 GL ++HS V+H D+KPSN++ +T + + DFGL+ + F + T Y + Sbjct: 177 GLDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTED---VYFPKDLRGTEIYMS 232 Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272 PE++L +G++ DI+S+G L M + P Sbjct: 233 PEVIL-CRGHSTKADIYSLGATLIHMQTGTPP------------------------WVKR 267 Query: 273 INMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 328 A + K + +L++ L NPN R + L H Sbjct: 268 YPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHE 323 >5TE0-A nrPDB Length = 347 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 65/323 (20%), Positives = 122/323 (37%), Gaps = 57/323 (17%) Query: 17 TEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF 76 T G+G G G V + Q V + + EG + +V + A+K++ Sbjct: 2 TSGLGSGYIGRVFGIGRQQVTVD------EVLAEGGFAIVFLVR-TSNGMKCALKRMF-V 53 Query: 77 EHQTYCQRTLREIQILLRFR-HENVIGIRDI-LRASTLEAMRDVYIVQDLMET----DLY 130 ++ Q REIQI+ H+N++G D + + + +V I+ D +L Sbjct: 54 NNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLM 113 Query: 131 KLLKSQQLSNDHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLLINTTCDLKICDFGLA 188 + + + + +H ++HRDLK N+L++ +CDFG A Sbjct: 114 NQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSA 173 Query: 189 --RIADPEHDHTGFLTEYV---ATRWYRAPEI--MLNSKGYTKSIDIWSVGCILAEMLSN 241 + +P+ + + + + T YRAPE+ + + K T DIW++GC+L ++ Sbjct: 174 TNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYF 233 Query: 242 RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDS 301 F + S +D++C Sbjct: 234 TLPFGESQVAICDGNFTIPDNSRYSQDMHC------------------------------ 263 Query: 302 KALDLLDRMLTFNPNKRITVEEA 324 L+ ML +P+KR + + Sbjct: 264 ----LIRYMLEPDPDKRPDIYQV 282 >4EUU-A nrPDB Length = 319 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 106/299 (35%), Gaps = 39/299 (13%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + +G+GA V AIK + +RE ++L + H+N++ Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 70 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLK----SQQLSNDHICYFLYQILRGLKYI 157 + I +T V I++ LY +L+ + L L ++ G+ ++ Sbjct: 71 KLFAIEEETT--TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 128 Query: 158 HSANVLHRDLKPSNLL--INTTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 ++HR++KP N++ I K+ DFG AR + + T Y P Sbjct: 129 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY----GTEEYLHP 184 Query: 214 EIML-------NSKGYTKSIDIWSVGCILAEMLSNRPIF-PGKHYLDQLNHILGILGSPS 265 ++ + K Y ++D+WS+G + F P + + I+ Sbjct: 185 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 244 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDL-------LDRMLTFNPNK 317 ++ + + + W+ P S S + L L +L + K Sbjct: 245 SGAISGVQKAENG----------PIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEK 293 >5WNO-A nrPDB Length = 330 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 55/213 (25%), Positives = 93/213 (43%), Gaps = 12/213 (5%) Query: 43 TQLQYIGEGAYGMVSSA-----YDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 + +G GA+G V + K VAIK Q+ L E + R RH Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVF--QTDQSQTDEMLEEATNMFRLRH 82 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYI 157 +N++ I + ++ V I + L + L + L + YQI G++Y+ Sbjct: 83 DNLLKIIGFCMHD--DGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYL 140 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 217 V+HRDL N+L+ ++I DFGL++I + D + VA +W A EI Sbjct: 141 EKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKW-LAIEIF- 198 Query: 218 NSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKH 249 + YT + D+W+ G E+++ + + G Sbjct: 199 SKHCYTHASDVWAFGVTCWEIITFGQSPYQGMS 231 >4EUT-A nrPDB Length = 396 Score = 170 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 106/299 (35%), Gaps = 39/299 (13%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + +G+GA V AIK + +RE ++L + H+N++ Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 70 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLK----SQQLSNDHICYFLYQILRGLKYI 157 + I +T V I++ LY +L+ + L L ++ G+ ++ Sbjct: 71 KLFAIEEETT--TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 128 Query: 158 HSANVLHRDLKPSNLL--INTTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 ++HR++KP N++ I K+ DFG AR + + T Y P Sbjct: 129 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY----GTEEYLHP 184 Query: 214 EIML-------NSKGYTKSIDIWSVGCILAEMLSNRPIF-PGKHYLDQLNHILGILGSPS 265 ++ + K Y ++D+WS+G + F P + + I+ Sbjct: 185 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 244 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDL-------LDRMLTFNPNK 317 ++ + + + W+ P S S + L L +L + K Sbjct: 245 SGAISGVQKAENG----------PIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEK 293 >2PMN-X nrPDB Length = 348 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 73/319 (22%), Positives = 119/319 (37%), Gaps = 51/319 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI----------------SPFEHQTYCQRT 85 Y ++ + +G + + A+KK ++ Sbjct: 33 YRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDDF 90 Query: 86 LREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD--------LYKLLKSQQ 137 E+QI+ ++E + I+ +VYI+ + ME D + L K+ Sbjct: 91 KNELQIITDIKNEYCLTCEGIITNYD-----EVYIIYEYMENDSILKFDEYFFVLDKNYT 145 Query: 138 --LSNDHICYFLYQILRGLKYIH-SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPE 194 + I + +L YIH N+ HRD+KPSN+L++ +K+ DFG + E Sbjct: 146 CFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFG-----ESE 200 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGY-TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQ 253 + + T + PE N Y +DIWS+G L M N F K L + Sbjct: 201 YMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVE 260 Query: 254 LNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTF 313 L + + D N ++L L +K D +D L L Sbjct: 261 LFNNIRTKNIEYPLDRN--------HFLYPLTNKKSTCSNNFLSNED---IDFLKLFLRK 309 Query: 314 NPNKRITVEEALAHPYLEQ 332 NP +RIT E+AL H +L Sbjct: 310 NPAERITSEDALKHEWLAD 328 >5XD6-A nrPDB Length = 305 Score = 168 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 59/221 (26%), Positives = 91/221 (41%), Gaps = 22/221 (9%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 D+ Y IGEG+YG V AIKK+ + Q L ++ ++ R R Sbjct: 19 DITDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD--QEFLAQVSMVSRLR 75 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ----------LSNDHICYF 146 ENV+ + L + Y L+ +L ++ LS Sbjct: 76 QENVVALLGYCVDGPLRVLAYEY----APNGSLHDILHGRKGVKGAQPGPVLSWHQRVKI 131 Query: 147 LYQILRGLKYIHSA---NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE 203 RGL+Y+H +V+HRD+K SN+L+ KI DF L+ A P+ T Sbjct: 132 AVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQA-PDMAARLHSTR 190 Query: 204 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPI 244 + T Y APE + + D++S G +L E+L+ R Sbjct: 191 VLGTFGYHAPEYAMTGTL-STKSDVYSFGVVLLELLTGRKP 230 >6O8B-A nrPDB Length = 665 Score = 168 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 106/299 (35%), Gaps = 39/299 (13%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + +G+GA V AIK + +RE ++L + H+N++ Sbjct: 17 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 76 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLK----SQQLSNDHICYFLYQILRGLKYI 157 + I +T V I++ LY +L+ + L L ++ G+ ++ Sbjct: 77 KLFAIEEETT--TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 134 Query: 158 HSANVLHRDLKPSNLL--INTTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 ++HR++KP N++ I K+ DFG AR + + T Y P Sbjct: 135 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELY----GTEEYLHP 190 Query: 214 EIML-------NSKGYTKSIDIWSVGCILAEMLSNRPIF-PGKHYLDQLNHILGILGSPS 265 ++ + K Y ++D+WS+G + F P + + I+ Sbjct: 191 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 250 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDL-------LDRMLTFNPNK 317 ++ + + + W+ P S S + L L +L + K Sbjct: 251 SGAISGVQKAENG----------PIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEK 299 >6NT9-A nrPDB Length = 742 Score = 168 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 106/299 (35%), Gaps = 39/299 (13%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + +G+GA V AIK + +RE ++L + H+N++ Sbjct: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLK----SQQLSNDHICYFLYQILRGLKYI 157 + I +T V I++ LY +L+ + L L ++ G+ ++ Sbjct: 69 KLFAIEEETT--TRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 Query: 158 HSANVLHRDLKPSNLL--INTTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 ++HR++KP N++ I K+ DFG AR + + T Y P Sbjct: 127 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY----GTEEYLHP 182 Query: 214 EIML-------NSKGYTKSIDIWSVGCILAEMLSNRPIF-PGKHYLDQLNHILGILGSPS 265 ++ + K Y ++D+WS+G + F P + + I+ Sbjct: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDL-------LDRMLTFNPNK 317 ++ + + + W+ P S S + L L +L + K Sbjct: 243 SGAISGVQKAENG----------PIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEK 291 >3G2F-A nrPDB Length = 336 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 66/321 (20%), Positives = 119/321 (37%), Gaps = 40/321 (12%) Query: 28 VEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR 87 +E +P L+ IG G YG V + + VA+K S Q + Sbjct: 1 MEAAASEPSLDLDNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFS----FANRQNFIN 54 Query: 88 EIQILL--RFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQLSNDHIC 144 E I H+N+ T + + +V + L K L C Sbjct: 55 EKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSC 114 Query: 145 YFLYQILRGLKYIH---------SANVLHRDLKPSNLLINTTCDLKICDFGLA------R 189 + + RGL Y+H + HRDL N+L+ I DFGL+ R Sbjct: 115 RLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNR 174 Query: 190 IADPEHDHTGFLTEYVATRWYRAPEIMLN------SKGYTKSIDIWSVGCILAEMLSNRP 243 + P + ++E V T Y APE++ + K +D++++G I E+ Sbjct: 175 LVRPGEEDNAAISE-VGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCT 233 Query: 244 -IFPGKHYLD-QLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDS 301 +FPG+ + Q+ + P+ ED+ +++ + + K AW + + Sbjct: 234 DLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQR------PKFPEAWKEN-SLAVR 286 Query: 302 KALDLLDRMLTFNPNKRITVE 322 + ++ + R+T + Sbjct: 287 SLKETIEDCWDQDAEARLTAQ 307 >3QD2-B nrPDB Length = 332 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 63/351 (17%), Positives = 125/351 (35%), Gaps = 99/351 (28%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVI 101 + +Q +G G +G+V A + V AIK+I + ++ +RE++ L + H ++ Sbjct: 8 FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV 67 Query: 102 GIRDILRASTLEAMR--------------------------------------------- 116 + + E + Sbjct: 68 RYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQL 127 Query: 117 -------DVYIVQDLMETDLYKLLKSQQLSNDHI-----CYFLYQILRGLKYIHSANVLH 164 +YI L + K +++ S + + QI ++++HS ++H Sbjct: 128 QPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLMH 187 Query: 165 RDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFL---------TEYVATRWYRAPEI 215 RDLKPSN+ +K+ DFGL D + + L T V T+ Y +PE Sbjct: 188 RDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQ 247 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + + Y+ +DI+S+G IL E+L + ++++ I + Sbjct: 248 I-HGNNYSHKVDIFSLGLILFELL-----YSFSTQMERVRIITDVRN------------- 288 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 K + + + +P+ D ML+ +P +R + + Sbjct: 289 ----------LKFPLLFTQKYPQEHMMVQD----MLSPSPTERPEATDIIE 325 >4F9B-A nrPDB Length = 361 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 90/365 (24%), Positives = 144/365 (39%), Gaps = 65/365 (17%) Query: 23 GVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVR---KTRVAIKKISPFEHQ 79 GV ++E + + + IGEG + V A ++ + ++A+K + P H Sbjct: 4 GVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP 63 Query: 80 TYCQRTLREIQILLRFR-HENVIGIRDILRASTLEAMRDVYIVQDLMETDLY-KLLKSQQ 137 R E+Q L +NV+G++ R + V I +E + + +L S Sbjct: 64 I---RIAAELQCLTVAGGQDNVMGVKYCFRKND-----HVVIAMPYLEHESFLDILNS-- 113 Query: 138 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLK-ICDFGLA-------- 188 LS + ++ + + LK IH ++HRD+KPSN L N + DFGLA Sbjct: 114 LSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKI 173 Query: 189 ---RIADPEHDHTGFLTEYV--------------ATRWYRAPEIMLNSKGYTKSIDIWSV 231 + E T +RAPE++ T +ID+WS Sbjct: 174 ELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSA 233 Query: 232 GCILAEMLSNRPIFP-GKHYLDQLNHILGILGSP--------------SQEDLNCIINMK 276 G I +LS R F L L I+ I GS +++ K Sbjct: 234 GVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRK 293 Query: 277 ARNYLQSLPSKTKVAWAKL---------FPKSDSKALDLLDRMLTFNPNKRITVEEALAH 327 L+ + S T + + + + +A DLLD++L NP RIT EEAL H Sbjct: 294 LCERLRGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLH 353 Query: 328 PYLEQ 332 P+ + Sbjct: 354 PFFKD 358 >5IKW-A nrPDB Length = 310 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 112/286 (39%), Gaps = 23/286 (8%) Query: 36 FDVGPRYTQLQY-IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 F VG L+ + EG + V H R A+K++ + REI I+ Sbjct: 9 FAVGRHQVTLEESLAEGGFSTVFLVRTHG-GIRCALKRM-YVNNMPDLNVCKREITIMKE 66 Query: 95 FR-HENVIGIRDILRASTLEAMRDVYIVQDLME-----TDLYKLLKSQQLSNDHICYFLY 148 H+N++G D S + + +V I+ + + K L++ + + Sbjct: 67 LSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTG-FTEPEVLQIFC 125 Query: 149 QILRGLKYIHSAN--VLHRDLKPSNLLINTTCDLKICDFGLA--RIADPEHDHTGFLTEY 204 + +H ++HRDLK N+L+N + +CDFG A + +P+ D + E Sbjct: 126 DTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEE 185 Query: 205 V---ATRWYRAPEI--MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 259 + T YRAPE+ + K T DIW++GC+L ++ F Q+ G Sbjct: 186 IKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGES----QVAICDG 241 Query: 260 ILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALD 305 P + I+ R L+ P + + A D Sbjct: 242 NFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAAAD 287 >4FL3-A nrPDB Length = 635 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 64/309 (20%), Positives = 125/309 (40%), Gaps = 26/309 (8%) Query: 1 MAAAAAQGGGGGE--PRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQL-QYIGEGAYGMVS 57 +A AA G E P TE E+ + + T + +G G +G V Sbjct: 327 LAPWAADKGPQREALPMDTEVFESPFADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVK 386 Query: 58 SAYDHVRKTRVA-----IKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTL 112 Y ++K +K + L E ++ + + ++ + I A + Sbjct: 387 KGYYQMKKVVKTVAVKILK--NEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES- 443 Query: 113 EAMRDVYIVQDLME-TDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPS 170 +V ++ E L K L+ + + + +I ++Q+ G+KY+ +N +HRDL Sbjct: 444 -----WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAAR 498 Query: 171 NLLINTTCDLKICDFGLARIADPEHDHTGFLT-EYVATRWYRAPEIMLNSKGYTKSIDIW 229 N+L+ T KI DFGL++ + ++ T +WY APE + K ++ D+W Sbjct: 499 NVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYK-FSSKSDVW 556 Query: 230 SVGCILAEMLS-NRPIFPGK--HYLDQLNHILGILGSP--SQEDLNCIINMKARNYLQSL 284 S G ++ E S + + G + + +G P ++ ++N+ +++ Sbjct: 557 SFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENR 616 Query: 285 PSKTKVAWA 293 P V Sbjct: 617 PGFAAVELR 625 >4IDT-A nrPDB Length = 356 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 75/361 (20%), Positives = 124/361 (34%), Gaps = 70/361 (19%) Query: 5 AAQGGGGGEPRRTEGVGPGV-------PGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVS 57 AA+G EP GV P + E + + +G G++G V Sbjct: 37 AARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQL-----RLGRGSFGEVH 91 Query: 58 SAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRD 117 D + A+KK+ + E+ ++ + +R Sbjct: 92 RMEDKQTGFQCAVKKVRLEVFRAE------ELMACAGLTSPRIVPLYGAVREGPW----- 140 Query: 118 VYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN 175 V I +L+E L +L+K Q L D Y+L Q L GL+Y+HS +LH D+K N+L++ Sbjct: 141 VNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLS 200 Query: 176 TTC-DLKICDFGLARIADPEHDHTGFLTEYV--ATRWYRAPEIMLNSKGYTKSIDIWSVG 232 + +CDFG A P+ LT T + APE++L + +D+WS Sbjct: 201 SDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG-RSCDAKVDVWSSC 259 Query: 233 CILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAW 292 C++ ML+ + S P + Sbjct: 260 CMMLHMLNGCHP------------------------WTQFFRGPLCLKIASEPPPVREIP 295 Query: 293 AKLFPKSDSKALDLLDRMLTFNPNKRITVEEA-------------LAHPYLEQYYDPTDE 339 P + + L P R++ E L P+ +Y +P Sbjct: 296 PSCAPLTAQA----IQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHP 351 Query: 340 P 340 P Sbjct: 352 P 352 >4F0G-A nrPDB Length = 287 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 59/315 (18%), Positives = 114/315 (36%), Gaps = 58/315 (18%) Query: 23 GVPGEVEMVKGQ-PFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS------P 75 G G E K + P + IG+G +G+V K+ VAIK + Sbjct: 1 GAMGGSEFPKSRLPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGE 60 Query: 76 FEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLL- 133 E Q RE+ I+ H N++ + ++ +V + + DLY L Sbjct: 61 TEMIEKFQEFQREVFIMSNLNHPNIVKLYGLMHNPPR-------MVMEFVPCGDLYHRLL 113 Query: 134 -KSQQLSNDHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLL---INTTCDL--KICDF 185 K+ + + I G++Y+ + N ++HRDL+ N+ ++ + K+ DF Sbjct: 114 DKAHPIKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADF 173 Query: 186 GLARIADPEHDHTGFLTEYVATRWYRAPEIM-LNSKGYTKSIDIWSVGCILAEMLSNRPI 244 GL++ + ++ + + APE + + YT+ D +S IL +L+ Sbjct: 174 GLSQQS------VHSVSGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGP 227 Query: 245 FPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKAL 304 F Y + I ++ ++P + Sbjct: 228 FDEYSYGK----------------IKFINMIREEGLRPTIPEDCPPRLRNV--------- 262 Query: 305 DLLDRMLTFNPNKRI 319 ++ + +P KR Sbjct: 263 --IELCWSGDPKKRP 275 >2QKW-B nrPDB Length = 321 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 62/290 (21%), Positives = 115/290 (39%), Gaps = 19/290 (6%) Query: 37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 + + IG G +G V +VA+K+ +P Q + I+ L R Sbjct: 36 EATNNFDHKFLIGHGVFGKVYKGVLR-DGAKVALKRRTPESSQGIEEFETE-IETLSFCR 93 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLY-KLLKSQQLSNDHICYFLYQILRGLK 155 H +++ + + Y+ ++ LY L + +S + RGL Sbjct: 94 HPHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLH 153 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 215 Y+H+ ++HRD+K N+L++ KI DFG+++ E D T T T Y PE Sbjct: 154 YLHTRAIIHRDVKSINILLDENFVPKITDFGISKK-GTELDQTHLSTVVKGTLGYIDPEY 212 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + + T+ D++S G +L E+L R + +N + S + L I++ Sbjct: 213 FIKGRL-TEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQLEQIVDP 271 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 + ++ P+S K D + L + R ++ + L Sbjct: 272 NLADKIR--------------PESLRKFGDTAVKCLALSSEDRPSMGDVL 307 >5C26-A nrPDB Length = 299 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 54/261 (20%), Positives = 111/261 (42%), Gaps = 23/261 (8%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVA-----IKKISPFEHQTYCQRTLREIQILLRFRHENV 100 + +G G +G V Y ++K +K + L E ++ + + + Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILK--NEANDPALKDELLAEANVMQQLDNPYI 90 Query: 101 IGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIH 158 + + I A + +V ++ E L K L+ + + + +I ++Q+ G+KY+ Sbjct: 91 VRMIGICEAES------WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 144 Query: 159 SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLT-EYVATRWYRAPEIML 217 +N +HRDL N+L+ T KI DFGL++ + ++ T +WY APE + Sbjct: 145 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECIN 203 Query: 218 NSKGYTKSIDIWSVGCILAEMLS-NRPIFPGK--HYLDQLNHILGILGSP--SQEDLNCI 272 K ++ D+WS G ++ E S + + G + + +G P ++ + Sbjct: 204 YYK-FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 262 Query: 273 INMKARNYLQSLPSKTKVAWA 293 +N+ +++ P V Sbjct: 263 MNLCWTYDVENRPGFAAVELR 283 >5E8V-A nrPDB Length = 316 Score = 160 bits (406), Expect = 7e-40, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 114/299 (38%), Gaps = 30/299 (10%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRK----TRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 +G+G + V A VA+K E+ ++ +T ++I + +HE Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASW--KTEKDIFSDINLKHE 69 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 158 N++ T + I + +L + L +S + + + RG+ ++H Sbjct: 70 NILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLH 129 Query: 159 SAN---------VLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLT-EYVATR 208 S + ++HRDLK SN+L+ +CDFGL+ DP V T Sbjct: 130 SDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 189 Query: 209 WYRAPEIMLNSKGYT-----KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS 263 Y APE++ ++ K D++S+ +L EM S + + ++ GS Sbjct: 190 RYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRC------NAVGEVKDYEPPFGS 243 Query: 264 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVE 322 +E C+ +M + + W + + L +P R+T + Sbjct: 244 KVRE-HPCVASMADNVLADAGRPEIPSFWLN--HQGIQMVCETLTECWDHDPEARLTAQ 299 >4G3E-A nrPDB Length = 352 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 53/203 (26%), Positives = 89/203 (43%), Gaps = 17/203 (8%) Query: 47 YIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDI 106 +G G++G V D + A+KK+ + E+ ++ + Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVE------ELVACAGLSSPRIVPLYGA 134 Query: 107 LRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLH 164 +R V I +L+E L +L+K L D Y+L Q L GL+Y+H+ +LH Sbjct: 135 VREGPW-----VNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILH 189 Query: 165 RDLKPSNLLINTTC-DLKICDFGLARIADPEHDHTGFLTEYV--ATRWYRAPEIMLNSKG 221 D+K N+L+++ +CDFG A P+ LT T + APE+++ K Sbjct: 190 GDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-KP 248 Query: 222 YTKSIDIWSVGCILAEMLSNRPI 244 +DIWS C++ ML+ Sbjct: 249 CDAKVDIWSSCCMMLHMLNGCHP 271 >2QLU-A nrPDB Length = 314 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 64/294 (21%), Positives = 114/294 (38%), Gaps = 28/294 (9%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 L+ G +G V A + VA+K + Q++ REI +HEN++ Sbjct: 18 QLLEIKARGRFGCVWKAQ--LMNDFVAVKIFPLQDKQSWQSE--REIFSTPGMKHENLLQ 73 Query: 103 IRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS--- 159 + + + I + L LK ++ + +C+ + RGL Y+H Sbjct: 74 FIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVP 133 Query: 160 --------ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 ++ HRD K N+L+ + + DFGLA +P G V TR Y Sbjct: 134 WCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKP-PGDTHGQVGTRRYM 192 Query: 212 APEIMLNSKGYTK----SIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 APE++ + + + ID++++G +L E++S G L I PS E Sbjct: 193 APEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLE 252 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 321 +L ++ K + K W K P + ++ + R++ Sbjct: 253 ELQEVVVHK------KMRPTIKDHWLKH-PGLAQLCV-TIEECWDHDAEARLSA 298 >3LMG-A nrPDB Length = 344 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 42/212 (19%), Positives = 87/212 (41%), Gaps = 14/212 (6%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKT----RVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 +L+ +G G +G V V IK I + Q + + H Sbjct: 34 RKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHA 93 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ--LSNDHICYFLYQILRGLKY 156 +++ + + S+L+ + Q L L ++ + L + + QI +G+ Y Sbjct: 94 HIVRLLGLCPGSSLQ-----LVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYY 148 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 + ++HR+L N+L+ + +++ DFG+A + P+ + +W A E + Sbjct: 149 LEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKW-MALESI 207 Query: 217 LNSKGYTKSIDIWSVGCILAEMLS-NRPIFPG 247 + YT D+WS G + E+++ + G Sbjct: 208 -HFGKYTHQSDVWSYGVTVWELMTFGAEPYAG 238 >4M66-A nrPDB Length = 325 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 51/208 (24%), Positives = 103/208 (49%), Gaps = 15/208 (7%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 +L+++G+G +G+V A+ VA+K ++ ++ E++ ++ R+ENV+ Sbjct: 23 KKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNS-------KKISWEVKAMVNLRNENVLL 75 Query: 103 IRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQ-QLSNDHICYFLYQILRGLKYIHSA 160 + + + + +V ME L LL+ + +C L +++ G+ Y+HS Sbjct: 76 LLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHSL 135 Query: 161 N--VLHRDLKPSNLLINTTCDLKICDFGLARI---ADPEHDHTGFLTEYVATRWYRAPEI 215 + +LHRDLKPSN+L++ K+ DFGL+ + + T Y PE+ Sbjct: 136 DPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPEL 195 Query: 216 MLN-SKGYTKSIDIWSVGCILAEMLSNR 242 + + +K+ D++S G ++ +L+ R Sbjct: 196 LFKVNLKASKASDVYSFGILVWAVLAGR 223 >6BFN-A nrPDB Length = 342 Score = 157 bits (397), Expect = 8e-39, Method: Composition-based stats. Identities = 54/212 (25%), Positives = 87/212 (41%), Gaps = 23/212 (10%) Query: 47 YIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY---CQRTLREIQILLRFRHENVIGI 103 IGEG +G V A +R T A+K++ + Q L E++ L RFRH N++ Sbjct: 29 KIGEGGFGCVYRAV--MRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 104 RDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ-----QLSNDHICYFLYQILRGLKYIH 158 + + L L L Q LS L R ++++H Sbjct: 87 AGYCAQNGF----YCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLH 142 Query: 159 --SANVLHRDLKPSNLLINTTCDLKICDFGLARI-----ADPEHDHTGFLTEYV-ATRWY 210 S +++H D+K SN+L++ K+ DFGLAR + P T+ V T Y Sbjct: 143 QDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAY 202 Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 242 E + + D +S G ++ E L+ + Sbjct: 203 LPEEYIKTGRL-AVDTDTFSFGVVVLETLAGQ 233 >5AR8-A nrPDB Length = 326 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 26/293 (8%) Query: 45 LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEH--QTYCQRTLREIQILLRFRHENVIG 102 L+Y+ GA G VSSA + +VA+K + + + LRE +IL + R ++ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 103 IRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ----LSNDHICYFLYQILRGLKYI 157 I I IV + M L +LL + ++ L++I G+ Y+ Sbjct: 97 ILGICNEPEFLG-----IVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYL 151 Query: 158 HSAN--VLHRDLKPSNLLINTTCDLKICDFGLA--RIADPEHDHTGFLTEYVATRWYRAP 213 H+ +LH DLK N+L++ +KI DFGL+ R+ + T Y P Sbjct: 152 HNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPP 211 Query: 214 EIMLNSKGY--TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 E + + DI+S I E+LS + F Q+ + + P Sbjct: 212 ENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRP------- 264 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 +IN ++ Y ++ + ++ + L ++ P R T EE Sbjct: 265 VINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLR-TFEEI 316 >6DC0-A nrPDB Length = 292 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 49/241 (20%), Positives = 90/241 (37%), Gaps = 43/241 (17%) Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ-QLSNDHICYFLYQILRGL 154 H N+ GI +++ T Y+ + D++ ++S+ +L + QI+ + Sbjct: 56 SHSNITGIVEVILGET-----KAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAV 110 Query: 155 KYIHSANVLHRDLKPSNLLIN--TTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 + H + ++ DLK + + L++ I E D L++ Y + Sbjct: 111 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDD---ALSDKHGCPAYVS 167 Query: 213 PEIMLNSKGY-TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 PEI+ + Y K+ D+WS+G +L +L R F + I Sbjct: 168 PEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKI-------------- 213 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 R +P KA L+ +L P++R+T E L HP+ E Sbjct: 214 ------RRGQFCIPE-----------HISPKARCLIRSLLRREPSERLTAPEILLHPWFE 256 Query: 332 Q 332 Sbjct: 257 S 257 >5CEK-A nrPDB Length = 263 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 49/241 (20%), Positives = 90/241 (37%), Gaps = 43/241 (17%) Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ-QLSNDHICYFLYQILRGL 154 H N+ GI +++ T Y+ + D++ ++S+ +L + QI+ + Sbjct: 59 SHSNITGIVEVILGET-----KAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAV 113 Query: 155 KYIHSANVLHRDLKPSNLLIN--TTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 212 + H + ++ DLK + + L++ I E D L++ Y + Sbjct: 114 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDD---ALSDKHGCPAYVS 170 Query: 213 PEIMLNSKGY-TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271 PEI+ + Y K+ D+WS+G +L +L R F + I Sbjct: 171 PEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKI-------------- 216 Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 R +P KA L+ +L P++R+T E L HP+ E Sbjct: 217 ------RRGQFCIPE-----------HISPKARCLIRSLLRREPSERLTAPEILLHPWFE 259 Query: 332 Q 332 Sbjct: 260 S 260 >2Y4I-B nrPDB Length = 319 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 64/310 (20%), Positives = 129/310 (41%), Gaps = 40/310 (12%) Query: 34 QPFDVG-PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQI 91 Q +D+ + + IG+G +G V H VAI+ I +++ + RE+ Sbjct: 26 QEWDIPFEQLEIGELIGKGRFGQVYHGRWH---GEVAIRLIDIERDNEDQLKAFKREVMA 82 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ--LSNDHICYFLY 148 + RHENV+ + A I+ L + LY +++ + L + Sbjct: 83 YRQTRHENVVLFMGACMSPPHLA-----IITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQ 137 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYV--A 206 +I++G+ Y+H+ +LH+DLK N+ + + I DFGL I+ + Sbjct: 138 EIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNG 196 Query: 207 TRWYRAPEIM--------LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL 258 + APEI+ + ++K D++++G I E+ + F + I+ Sbjct: 197 WLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPA----EAII 252 Query: 259 GILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKR 318 +G+ + +L+ I K + + + F +K +D+L+++ N +R Sbjct: 253 WQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTF----TKLMDMLEKLPKRN--RR 306 Query: 319 ITVEEALAHP 328 ++ HP Sbjct: 307 LS------HP 310 >4BTK-A nrPDB Length = 337 Score = 143 bits (362), Expect = 8e-35, Method: Composition-based stats. Identities = 59/245 (24%), Positives = 96/245 (39%), Gaps = 20/245 (8%) Query: 26 GEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT 85 GE + + V R+ L+ IG G +G + A D + + VA+K Q Q Sbjct: 42 GEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQVL 98 Query: 86 LREIQILLRFR-HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ---LSND 141 E+ +L + + ++V R Y+V L +L L +SQ + Sbjct: 99 KMEVAVLKKLQGKDHVCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRSQPRGTFTLS 153 Query: 142 HICYFLYQILRGLKYIHSANVLHRDLKPSNL----LINTTCDLKICDFGLARIA---DPE 194 QIL ++ IHS LHRD+KPSN L +T + DFGLAR + Sbjct: 154 TTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGD 213 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 + + T Y + N + + D+WS+ +L E + + +Q+ Sbjct: 214 VRPPRNVAGFRGTVRYASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQV 272 Query: 255 NHILG 259 I Sbjct: 273 GMIKE 277 >5J0A-A nrPDB Length = 300 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 116/300 (38%), Gaps = 38/300 (12%) Query: 46 QYIGEGAYGM---VSSAYDHVRK---TRVAIKKISPFEHQTYC----QRTLREIQILLRF 95 Q +G +G V R + A+KKI+P + Y +R + E +IL Sbjct: 15 QKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSL 71 Query: 96 RHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQ------QLSNDHICYFLY 148 H N++G R A+ + + + E L L++ + I Sbjct: 72 HHPNIVGYRAFTEAND----GSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVAL 127 Query: 149 QILRGLKYIHS-ANVLHRDLKPSNLLINTTCD-LKICDFGLARIADPEHDHTGFLTEYVA 206 + RGLKY+H +LH D+K SN++I + +KICD G++ D + T Y+ Sbjct: 128 NMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIG 187 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 T ++ E + + T DI++ G L EM++ HI + Sbjct: 188 TEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP-----------HINLSNDDDDE 236 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 + + Y +L ++ + +L +S K ++L +P R + + Sbjct: 237 DKTFDESDFDDEAYYAALGTRPPINMEEL-DESYQKVIELFSVCTNEDPKDRPSAAHIVE 295 >4NFN-A nrPDB Length = 309 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 59/245 (24%), Positives = 96/245 (39%), Gaps = 20/245 (8%) Query: 26 GEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRT 85 GE + + V R+ L+ IG G +G + A D + + VA+K Q Q Sbjct: 7 GEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQVL 63 Query: 86 LREIQILLRFR-HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ---LSND 141 E+ +L + + ++V R Y+V L +L L +SQ + Sbjct: 64 KMEVAVLKKLQGKDHVCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRSQPRGTFTLS 118 Query: 142 HICYFLYQILRGLKYIHSANVLHRDLKPSNL----LINTTCDLKICDFGLARIA---DPE 194 QIL ++ IHS LHRD+KPSN L +T + DFGLAR + Sbjct: 119 TTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGD 178 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 + + T Y + N + + D+WS+ +L E + + +Q+ Sbjct: 179 VRPPRNVAGFRGTVRYASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQV 237 Query: 255 NHILG 259 I Sbjct: 238 GMIKE 242 >5L2Q-C nrPDB Length = 320 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 52/307 (16%), Positives = 104/307 (33%), Gaps = 69/307 (22%) Query: 57 SSAYDHVRKTRVAIKK----------ISPFEHQTYCQRTLREIQILLRFR-HENVIGIRD 105 A +K I E + E +L + V+ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 106 ILRASTLEAMRD-------------VYIVQD-LMETDLYK-----------LLKSQQLSN 140 + + T E + D + +V D L D ++K ++LS Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 141 DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD-LKICDFGLARIADPEHDHTG 199 Y ++R ++ +H N++HRDLK N+++N + I +F L + E D Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGD--- 209 Query: 200 FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 259 L + + Y +P+++ K D+W++G +L ML + F + I Sbjct: 210 LLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKI-- 267 Query: 260 ILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI 319 + ++P +V+ + L+ ++L +P +R+ Sbjct: 268 ------------------KAAEYTIPEDGRVSENTVC---------LIRKLLVLDPQQRL 300 Query: 320 TVEEALA 326 + L Sbjct: 301 AAADVLE 307 >4LQP-A nrPDB Length = 508 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 34/165 (20%), Positives = 70/165 (42%), Gaps = 9/165 (5%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE--HQTYCQRTLREIQILLRFRHEN 99 + ++ IG+GA+G V A+K + E + E +L Sbjct: 104 FHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPW 163 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQ-LSNDHICYFLYQILRGLKYI 157 V+ + + + + +Y++ + + DL +L Q + D +++ + + ++ I Sbjct: 164 VVSLY-----YSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETI 218 Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLT 202 H +HR +KP N+LI+ +K+ DFGL+ HD + Sbjct: 219 HKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKK 263 Score = 89.6 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 32/141 (22%), Positives = 49/141 (34%), Gaps = 33/141 (23%) Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 V T Y APEI L +GY + D WS+G I+ E L P F + + Sbjct: 314 KSRRLMAYSTVGTPDYIAPEIFL-YQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETY 372 Query: 255 NHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFN 314 I+ + D I +A DL+ R+LT Sbjct: 373 RKIMNFEQTLQFPDDIHI---------------------------SYEAEDLIRRLLTH- 404 Query: 315 PNKRI----TVEEALAHPYLE 331 ++R+ +E +HP+ Sbjct: 405 ADQRLGRHGGADEIKSHPFFR 425 >3VHK-A nrPDB Length = 368 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 52/207 (25%), Positives = 89/207 (42%), Gaps = 36/207 (17%) Query: 122 QDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLK 181 ++ DLYK L+ +H+ + +Q+ +G++++ S +HRDL N+L++ +K Sbjct: 185 EEEAPEDLYKDF----LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVK 240 Query: 182 ICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS- 240 ICDFGLAR + D+ + +W APE + + + YT D+WS G +L E+ S Sbjct: 241 ICDFGLARDIYKDPDYVRKGDARLPLKW-MAPETIFD-RVYTIQSDVWSFGVLLWEIFSL 298 Query: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300 +PG ++ L M+A +Y P+ Sbjct: 299 GASPYPGVKIDEEFCR-----------RLKEGTRMRAPDYT--------------TPEMY 333 Query: 301 SKALDLLDRMLTFNPNKRITVEEALAH 327 LD P++R T E + H Sbjct: 334 QTMLD----CWHGEPSQRPTFSELVEH 356 Score = 70.8 bits (172), Expect = 9e-13, Method: Composition-based stats. Identities = 22/104 (21%), Positives = 41/104 (39%), Gaps = 9/104 (8%) Query: 40 PRYTQLQYIGEGAYGMVSSA----YDHV-RKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 R + +G GA+G V A D VA+K + + + + E++IL+ Sbjct: 29 DRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIH 88 Query: 95 F-RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ 137 H NV+ + + IV+ +L L+S++ Sbjct: 89 IGHHLNVVNLLGACTKP---GGPLMVIVEFCKFGNLSTYLRSKR 129 >3HNG-A nrPDB Length = 360 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 45/207 (21%), Positives = 93/207 (44%), Gaps = 17/207 (8%) Query: 105 DILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLH 164 + +S + + + V++ ++D + + ++ + + + +Q+ RG++++ S +H Sbjct: 166 ESFASSGFQEDKSLSDVEEEEDSDGF---YKEPITMEDLISYSFQVARGMEFLSSRKCIH 222 Query: 165 RDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTK 224 RDL N+L++ +KICDFGLAR D+ + +W APE + + K Y+ Sbjct: 223 RDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKW-MAPESIFD-KIYST 280 Query: 225 SIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQS 283 D+WS G +L E+ S +PG + L + M+A Y Sbjct: 281 KSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFC-----------SRLREGMRMRAPEYSTP 329 Query: 284 LPSKTKVAWAKLFPKSDSKALDLLDRM 310 + + PK + +L++++ Sbjct: 330 EIYQIMLDCWHRDPKERPRFAELVEKL 356 Score = 71.5 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 23/104 (22%), Positives = 41/104 (39%), Gaps = 9/104 (8%) Query: 40 PRYTQLQYIGEGAYGMVSSA-----YDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR 94 R + +G GA+G V A VA+K + + + + E++IL Sbjct: 27 ERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTH 86 Query: 95 F-RHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ 137 H NV+ + T + + IV+ +L LKS++ Sbjct: 87 IGHHLNVVNLLGAC---TKQGGPLMVIVEYCKYGNLSNYLKSKR 127 >2PZI-A nrPDB Length = 681 Score = 135 bits (340), Expect = 4e-32, Method: Composition-based stats. Identities = 65/290 (22%), Positives = 108/290 (37%), Gaps = 50/290 (17%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDH-VRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 V +Y I G G + A D V V +K + + E Q L Sbjct: 78 VAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV 137 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKY 156 H +++ I + + + YIV + + K K Q+L +L +IL L Y Sbjct: 138 HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSY 197 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFG-LARIADPEHDHTGFLTEYVATRWYRAPEI 215 +HS +++ DLKP N+++ LK+ D G ++RI + + T ++APEI Sbjct: 198 LHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY--------GTPGFQAPEI 248 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + T + DI++VG LA + + P Sbjct: 249 VRTGP--TVATDIYTVGRTLAALTLDLP-------------------------------T 275 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 + Y+ LP + DS LL R + +P +R T E + Sbjct: 276 RNGRYVDGLPEDDP-----VLKTYDSYGR-LLRRAIDPDPRQRFTTAEEM 319 >4Y12-A nrPDB Length = 375 Score = 134 bits (338), Expect = 5e-32, Method: Composition-based stats. Identities = 65/290 (22%), Positives = 108/290 (37%), Gaps = 50/290 (17%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDH-VRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR 96 V +Y I G G + A D V V +K + + E Q L Sbjct: 117 VAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV 176 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKY 156 H +++ I + + + YIV + + K K Q+L +L +IL L Y Sbjct: 177 HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSY 236 Query: 157 IHSANVLHRDLKPSNLLINTTCDLKICDFG-LARIADPEHDHTGFLTEYVATRWYRAPEI 215 +HS +++ DLKP N+++ LK+ D G ++RI + + T ++APEI Sbjct: 237 LHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY--------GTPGFQAPEI 287 Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275 + T + DI++VG LA + + P Sbjct: 288 VRTGP--TVATDIYTVGRTLAALTLDLP-------------------------------T 314 Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 + Y+ LP + DS LL R + +P +R T E + Sbjct: 315 RNGRYVDGLPEDDP-----VLKTYDSYGR-LLRRAIDPDPRQRFTTAEEM 358 >4RT7-A nrPDB Length = 415 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 47/220 (21%), Positives = 86/220 (39%), Gaps = 12/220 (5%) Query: 87 REIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYF 146 RE+QI H + I + S ++ + L + L+ + + F Sbjct: 198 REVQI-----HPDSDQISGLHGNSFHSEDE----IEYENQKRLEEEEDLNVLTFEDLLCF 248 Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 YQ+ +G++++ + +HRDL N+L+ +KICDFGLAR + ++ + Sbjct: 249 AYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLP 308 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPS 265 +W APE + YT D+WS G +L E+ S +PG ++ Sbjct: 309 VKW-MAPESLFEG-IYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMD 366 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALD 305 Q + S+ + ++ L + D Sbjct: 367 QPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLAD 406 Score = 81.9 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 19/102 (18%), Positives = 44/102 (43%), Gaps = 12/102 (11%) Query: 43 TQLQYIGEGAYGMVSSAY-----DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF-R 96 + +G GA+G V +A +VA+K + + + + E++++ + Sbjct: 68 EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGS 127 Query: 97 HENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ 137 HEN++ + S +Y++ + DL L+S++ Sbjct: 128 HENIVNLLGACTLSG-----PIYLIFEYCCYGDLLNYLRSKR 164 >5X1R-A nrPDB Length = 302 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 58/252 (23%), Positives = 93/252 (36%), Gaps = 36/252 (14%) Query: 18 EGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFE 77 G G P + G F+ + + IGEG +G+V AYDH + +AIK+ P Sbjct: 2 SGTGITKPNSNSLPSGYRFN---EFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTS 58 Query: 78 --------------------HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRD 117 Q ++E ++L RF H G+ +LR E Sbjct: 59 LAKRNDDLSIGLRGERFGKTFQAGLNSFIQEARLLARFSHP---GLLHVLRF--WEENGT 113 Query: 118 VYIVQDLMETDLYKLLKSQ---QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLI 174 Y+ K L++Q ++ I L + + IH LHRD+ N+ I Sbjct: 114 AYMGTQFYSGTTLKNLQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQI 173 Query: 175 NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKG--YTKSIDIWSVG 232 + + DFG AR E + TE V + E + DI+++G Sbjct: 174 QESQLPVLLDFGSAR---KEIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALG 230 Query: 233 CILAEMLSNRPI 244 +L ++ P Sbjct: 231 AVLHTLIVGSPP 242 >5VC6-A nrPDB Length = 289 Score = 131 bits (330), Expect = 5e-31, Method: Composition-based stats. Identities = 59/313 (18%), Positives = 105/313 (33%), Gaps = 72/313 (23%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKK-ISPFEHQTYCQRTLREIQILLRF-RHEN 99 + +L+ IG G +G V + AIK+ P Q LRE+ +H + Sbjct: 13 FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH 72 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-----LSNDHICYFLYQILRGL 154 V+ +++ Y L + + L Q+ RGL Sbjct: 73 VVRYFSAWAEDDHMLIQNEY----CNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGL 128 Query: 155 KYIHSANVLHRDLKPSNLLINTTC-------------------DLKICDFG-LARIADPE 194 +YIHS +++H D+KPSN+ I+ T KI D G + RI+ P+ Sbjct: 129 RYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ 188 Query: 195 HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 254 + + A E++ + + DI+++ + + P DQ Sbjct: 189 VEEGDSR--------FLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLP--RNGDQW 237 Query: 255 NHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFN 314 + I LP +V + +LL M+ + Sbjct: 238 HEIRQ----------------------GRLPRIPQV--------LSQEFTELLKVMIHPD 267 Query: 315 PNKRITVEEALAH 327 P +R + + H Sbjct: 268 PERRPSAMALVKH 280 >4JRN-A nrPDB Length = 372 Score = 130 bits (328), Expect = 7e-31, Method: Composition-based stats. Identities = 61/361 (16%), Positives = 109/361 (30%), Gaps = 92/361 (25%) Query: 12 GEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQY-----------IGEGAYGMVSSAY 60 G+P+ E + V P DV R+ + +G G + V A Sbjct: 31 GQPQALE--NSERLDRILTVAAWPPDVPKRFVSVTTGETRTLVRGAPLGSGGFATVYEAT 88 Query: 61 DHVRKTRVAIKKISPFEHQTYCQ--RTLREIQILLRFRH----------------ENVIG 102 D +A+K + T RE F +V+ Sbjct: 89 DVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQESCRFMVPSDVVM 148 Query: 103 IRD------ILRASTLEAMRDVYIVQDLMETDLYKLL---------KSQQLSNDHICYFL 147 + ++ T + + +++ E D+ K++ + Y Sbjct: 149 LEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVNKSEFGLVVRMYLS 208 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVAT 207 Q ++ + + + ++H D+KP+N L+ L + DFG RI + + + T Sbjct: 209 SQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINNS-------VGRAIGT 261 Query: 208 RWYRAPEIMLNSKG--YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265 Y PE + G YT D W +G L + P D L+ Sbjct: 262 PGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYLHF--------- 312 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325 P + DL+ +L +P KR+ +AL Sbjct: 313 ----------------------------ADCPSTPELVQDLIRSLLNRDPQKRMLPLQAL 344 Query: 326 A 326 Sbjct: 345 E 345 >5FQD-C nrPDB Length = 341 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 45/215 (20%), Positives = 85/215 (39%), Gaps = 18/215 (8%) Query: 32 KGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQI 91 F VG +Y ++ IG G++G + A + VA+K + + L E ++ Sbjct: 11 SKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK---LESQKARHPQLLYESKL 67 Query: 92 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQ 149 + +GI I + +V DL+ L L S++ + + Q Sbjct: 68 YKILQ--GGVGIPHIRWYG--QEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQ 123 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCDL---KICDFGLARIADPEHDHTGFL----T 202 ++ ++Y+H+ N +HRD+KP N L+ + DFGLA+ Sbjct: 124 MISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDK 183 Query: 203 EYVATRWYRAPEIMLNSKGYTKSIDIWSVG-CILA 236 T Y + L + ++ D+ S+G ++ Sbjct: 184 NLTGTARYASINAHLGIEQ-SRRDDMESLGYVLMY 217 >3SV0-A nrPDB Length = 483 Score = 128 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 50/223 (22%), Positives = 88/223 (39%), Gaps = 25/223 (11%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 VG ++ + IG G++G + + VAIK +T + L E +I + Sbjct: 5 VGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK---LENVKTKHPQLLYESKIYRILQG 61 Query: 98 ----ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQIL 151 N + + + +V DL+ L L S++LS + Q++ Sbjct: 62 GTGIPN-VRWFGVEGDYNV-------LVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMI 113 Query: 152 RGLKYIHSANVLHRDLKPSNLLIN---TTCDLKICDFGLARIADPEHDHTGFL----TEY 204 ++++HS + LHRD+KP N L+ + I DFGLA+ H Sbjct: 114 NRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNL 173 Query: 205 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 247 T Y + L + ++ D+ S+G +L L + G Sbjct: 174 TGTARYASVNTHLGIEQ-SRRDDLESLGYVLMYFLRGSLPWQG 215 >4TN6-A nrPDB Length = 318 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 60/257 (23%), Positives = 98/257 (38%), Gaps = 20/257 (7%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 VG RY + IG G++G + D VAIK + + + +I +++ Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHIESKIYKMMQGG- 62 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILRGLK 155 +GI I R E +V +V +L+ L L S++ S + Q++ ++ Sbjct: 63 ---VGIPTI-RWCGAEGDYNV-MVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIE 117 Query: 156 YIHSANVLHRDLKPSNLLIN---TTCDLKICDFGLARIADPEHDHTGFL----TEYVATR 208 YIHS N +HRD+KP N L+ + I DFGLA+ H T Sbjct: 118 YIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTA 177 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG---KHYLDQLNHILGILGSPS 265 Y + L + ++ D+ S+G +L + G + I S Sbjct: 178 RYASINTHLGIEQ-SRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTP 236 Query: 266 QEDLNCIINMKARNYLQ 282 E L + YL Sbjct: 237 IEVLCKGYPSEFATYLN 253 >4BTF-A nrPDB Length = 469 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 56/294 (19%), Positives = 112/294 (38%), Gaps = 18/294 (6%) Query: 23 GVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY- 81 +P ++++ + +GP +T+L+ + H V IK + + ++ Sbjct: 181 EIPQDLQIKEIPKEHLGPPWTKLKT---SKMSTIYRGEYHRS--PVTIKVFNNPQAESVG 235 Query: 82 --CQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ- 137 EI+ + +F N++ I I T+ + IV + E L +LL ++ Sbjct: 236 IVRFTFNDEIKTMKKFDSPNILRIFGICIDQTV-KPPEFSIVMEYCELGTLRELLDREKD 294 Query: 138 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADP-EHD 196 L+ + + RGL +H + LHR++ S+ L+ +K+ F L++ + Sbjct: 295 LTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRT 354 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKG-YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLN 255 E ++ Y +PE + N Y +I+S G +L E+ + + F G Sbjct: 355 AKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRE 414 Query: 256 HIL-----GILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKAL 304 + +G E L IIN + PS + + + Sbjct: 415 LVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILERLSAVEESTDKK 468 >4L68-A nrPDB Length = 340 Score = 124 bits (311), Expect = 8e-29, Method: Composition-based stats. Identities = 53/278 (19%), Positives = 108/278 (38%), Gaps = 32/278 (11%) Query: 54 GMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLE 113 G A + +A+K +S + + E+ L RH N+ + Sbjct: 54 GTTYKAL-LPDGSALAVKHLS--TCKLGEREFRYEMNQLWELRHSNLAPLLGFC-----V 105 Query: 114 AMRDVYIVQDLM-ETDLYKLLKSQQ--LSNDHICYFLYQILRGLKYIHSAN---VLHRDL 167 + ++V M L+ LL S + L RGL ++H +LH+++ Sbjct: 106 VEEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNI 165 Query: 168 KPSNLLINTTCDLKICDFGLARIADP-EHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSI 226 S +LI+ D +I D GLAR+ P +++ + F+T + Y APE + Sbjct: 166 CSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLA-SLKG 224 Query: 227 DIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPS 286 D++ +G +L E+ + G+ + L + L S + N++ + + + + Sbjct: 225 DVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEISK 284 Query: 287 KTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 ++A + + P +R ++ +A Sbjct: 285 FVEIALNCVSSR----------------PKERWSMFQA 306 >5VDK-A nrPDB Length = 297 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 50/314 (15%), Positives = 93/314 (29%), Gaps = 76/314 (24%) Query: 40 PRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKK-ISPFEHQTYCQRTLREIQILLRF-RH 97 + +++ IG G +G V + AIK+ + F + L E+ H Sbjct: 15 KEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHH 74 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYK------LLKSQQLSNDHICYFLYQIL 151 +V+ S+ + I + + + L QI Sbjct: 75 PHVVRYY-----SSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQIS 129 Query: 152 RGLKYIHSANVLHRDLKPSNLLINTTCD-----------------------LKICDFGLA 188 GL YIH+++++H D+KPSN+ I KI D G A Sbjct: 130 LGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHA 189 Query: 189 RIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 248 + G + A EI+ + DI+++G Sbjct: 190 TSINKPKVEEGDSR-------FLANEILQEDYRHLPKADIFALGLT-------------- 228 Query: 249 HYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLD 308 I G+ S + + +P + +++ LL Sbjct: 229 --------IAVAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSS-----------LLK 269 Query: 309 RMLTFNPNKRITVE 322 M+ + +R + Sbjct: 270 NMIQPDAEQRPSAA 283 >4MWI-A nrPDB Length = 294 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 55/268 (20%), Positives = 99/268 (36%), Gaps = 39/268 (14%) Query: 68 VAIKKISPFEH---QTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDL 124 VAIK + Q +EI+ + +F N++ I I T+ IV + Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETV-TPPQFSIVMEY 108 Query: 125 ME-TDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANV--LHRDLKPSNLLINTTCDL 180 E L +LL ++ L+ + RGL +H + LH ++ SN L+ + Sbjct: 109 CELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQV 168 Query: 181 KICDFGLAR-IADPEHDHTGFLTEYVATRWYRAP-EIMLNSKGYTKSIDIWSVGCILAEM 238 K+ F L + T T+ V + Y +P E+ Y +I+S G +L E+ Sbjct: 169 KLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEI 228 Query: 239 LSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPK 298 + F G + I ++ Q++ L Sbjct: 229 ATGDIPFQGCNS----EKIRKLVAVKRQQE-------------------------PLGED 259 Query: 299 SDSKALDLLDRMLTFNPNKRITVEEALA 326 S+ +++D +P+ R +V+E L Sbjct: 260 CPSELREIIDECRAHDPSVRPSVDEILK 287 >4M69-B nrPDB Length = 283 Score = 121 bits (303), Expect = 6e-28, Method: Composition-based stats. Identities = 55/288 (19%), Positives = 108/288 (37%), Gaps = 18/288 (6%) Query: 29 EMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTY---CQRT 85 ++ + +GP +T+L+ + H V IK + + ++ Sbjct: 1 QIKEIPKEHLGPPWTKLKT---SKMSTIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTF 55 Query: 86 LREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ-LSNDHI 143 EI+ + +F N++ I I T+ + IV + E L +LL ++ L+ Sbjct: 56 NDEIKTMKKFDSPNILRIFGICIDQTV-KPPEFSIVMEYCELGTLRELLDREKDLTMSVR 114 Query: 144 CYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADP-EHDHTGFLT 202 + + RGL +H + LHR++ S+ L+ +K+ F L++ + Sbjct: 115 SLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKA 174 Query: 203 EYVATRWYRAPEIMLNSKG-YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL--- 258 E ++ Y +PE + N Y +I+S G +L E+ + + F G + Sbjct: 175 ERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDK 234 Query: 259 --GILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKAL 304 +G E L IIN + PS + + + Sbjct: 235 KQEPVGQDCPELLREIINECRAHEPSQRPSVDGILERLSAVEESTDKK 282 >5OAT-A nrPDB Length = 411 Score = 118 bits (296), Expect = 4e-27, Method: Composition-based stats. Identities = 69/336 (20%), Positives = 116/336 (34%), Gaps = 88/336 (26%) Query: 44 QLQYIGEGAYGMVSSAYDHVRKT-----RVAIKKISPFEHQTYCQRTLR----------- 87 + I +G G+V SA +T A+K + ++ Q L+ Sbjct: 15 LGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETVPARM 74 Query: 88 ----------EIQILLRFRH----ENVIGIRDILRASTLEAMRD------------VYIV 121 EI++ R +H N++ I + A+ ++++ Sbjct: 75 YYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLL 134 Query: 122 QDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN----TT 177 + +L L + S L Q+L G+ ++ + + HRDLK NLL++ + Sbjct: 135 MKRYDCNLQSFLSTAP-STRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPES 193 Query: 178 CDLKICDFGLA---RIADPEHDHTGFLTEYVATRWYRAPEIMLNSKG------YTKSIDI 228 L I DFG + +T + + APEI+ G Y+K+ D+ Sbjct: 194 PILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYSKA-DL 252 Query: 229 WSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKT 288 W+VG I E+ + F G L N+ G L E I Sbjct: 253 WAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQA-------------- 298 Query: 289 KVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 L+ +L NPNKR+ E A Sbjct: 299 -----------------LVANLLKRNPNKRLDPEVA 317 >4NT4-A nrPDB Length = 312 Score = 115 bits (288), Expect = 4e-26, Method: Composition-based stats. Identities = 51/292 (17%), Positives = 100/292 (34%), Gaps = 31/292 (10%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF-R 96 VGP + + IG G +G + + VAIK ++ + E + Sbjct: 10 VGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM---EPMKSKAPQLHLEYRFYKLLGS 66 Query: 97 H-----ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKL--LKSQQLSNDHICYFLYQ 149 H + + I + +V +L+ L L + +++ S + Q Sbjct: 67 HADNAPDGIPRIYHLGTCGGRYNA----MVLELLGLSLEDLFNICARKFSLKTVLMIAKQ 122 Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTTCD-----LKICDFGLARIADPEHDHTGFL--- 201 +L ++Y+HS ++++RD+KP N LI T + I DFGLA+ + Sbjct: 123 LLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYRE 182 Query: 202 -TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI 260 T Y + + + ++ D+ ++G + L + G D L Sbjct: 183 HKSLTGTARYMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQK 240 Query: 261 LGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLT 312 +G + ++ + + P D L R+ Sbjct: 241 IGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPD-----YDFLRRLFQ 287 >5X18-A nrPDB Length = 295 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 49/263 (18%), Positives = 98/263 (37%), Gaps = 22/263 (8%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 VG Y + IGEG++G++ + + VAIK + + +IL Sbjct: 5 VGLHYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGT-- 62 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILRGLK 155 N+ L + +V DL+ L L ++ S + Q++ ++ Sbjct: 63 PNI-PYAYYFGQEGLHNI----LVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIE 117 Query: 156 YIHSANVLHRDLKPSNLLINTTCD-----LKICDFGLARIADPEHDHTGF----LTEYVA 206 +H+ ++++RD+KP N LI + + DFG+A+ Sbjct: 118 DLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSG 177 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG---KHYLDQLNHILGILGS 263 T Y + L + ++ D+ ++G + L + G + + I S Sbjct: 178 TARYMSINTHLGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRS 236 Query: 264 PSQEDLNCIINMKARNYLQSLPS 286 + DL + ++ YL+ + S Sbjct: 237 TNVYDLAQGLPVQFGRYLEIVRS 259 >5M07-A nrPDB Length = 276 Score = 114 bits (285), Expect = 7e-26, Method: Composition-based stats. Identities = 40/213 (18%), Positives = 82/213 (38%), Gaps = 33/213 (15%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF--EHQTYCQRTLREIQILLRFRHEN 99 YT ++ +G A G V A+K +SP + +R RE ++ R H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 100 VIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ---QLSNDHICYFLYQILRGLK 155 ++ + D E ++I D ++ D + + + L + + + L Sbjct: 92 ILEVHD-----RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALD 146 Query: 156 YIHSANVLHRDLKPSNLLINT----TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYR 211 Y H +LHRD+ P+N+++ + + + DFG+A Y Sbjct: 147 YAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-----------------PSYP 189 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPI 244 APE+ + ++ D +++ + + P Sbjct: 190 APELSAGADVDGRA-DQYALALTAIHLFAGAPP 221 >2CHL-A nrPDB Length = 351 Score = 114 bits (285), Expect = 8e-26, Method: Composition-based stats. Identities = 51/285 (17%), Positives = 97/285 (34%), Gaps = 22/285 (7%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 VGP + + IG G +G + + VAIK ++ + E + + Sbjct: 28 VGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPMKSRAPQLHLEYRFYKQLGS 84 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKL--LKSQQLSNDHICYFLYQILRGLK 155 + I +V +L+ L L L + S + Q++ ++ Sbjct: 85 GDGIPQVYYFGPCGKYNA----MVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRME 140 Query: 156 YIHSANVLHRDLKPSNLLINTTCD-----LKICDFGLARIADPEHDHTGFL----TEYVA 206 Y+HS N+++RD+KP N LI + + I DF LA+ Sbjct: 141 YVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTG 200 Query: 207 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 T Y + L + ++ D+ ++G + L + G D L +G + Sbjct: 201 TARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKR 258 Query: 267 EDLNCIINMKARNYLQSLPSKTKVAWAKL--FPKSDSKALDLLDR 309 ++ L ++ + + + DL DR Sbjct: 259 ATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 303 >1CSN-A nrPDB Length = 298 Score = 113 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 52/266 (19%), Positives = 100/266 (37%), Gaps = 22/266 (8%) Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQ 90 + GQ VG Y + IGEG++G++ + + +VAIK + R + Sbjct: 1 MSGQNNVVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYK 60 Query: 91 ILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLY 148 +L GI ++ E + +V ++ DL+ L LL ++ S + Sbjct: 61 LLAGC-----TGIPNVYYFGQ-EGLHNVLVI-DLLGPSLEDLLDLCGRKFSVKTVAMAAK 113 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLIN-----TTCDLKICDFGLARIADP----EHDHTG 199 Q+L ++ IH ++++RD+KP N LI + + DFG+ + +H Sbjct: 114 QMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYR 173 Query: 200 FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG---KHYLDQLNH 256 T Y + L + ++ D+ ++G + L + G + Sbjct: 174 EKKNLSGTARYMSINTHLGREQ-SRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYER 232 Query: 257 ILGILGSPSQEDLNCIINMKARNYLQ 282 I S +L + Y+ Sbjct: 233 IGEKKQSTPLRELCAGFPEEFYKYMH 258 >4L00-A nrPDB Length = 304 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 46/280 (16%), Positives = 96/280 (34%), Gaps = 56/280 (20%) Query: 58 SAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRD 117 +K +V +K + P H+ ++ + H++++ + + Sbjct: 53 EGTSEEKKIKVILKVLDP-SHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENI--- 108 Query: 118 VYIVQDLMET---DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLI 174 +V++ +E DL+ KS L+ Q+ L Y+ +++H ++ NLL+ Sbjct: 109 --MVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLL 166 Query: 175 NTTCD-------LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSID 227 +K+ D G+ + + + APE + +SK + + D Sbjct: 167 AREGIDSECGPFIKLSDPGIPITVLSRQECIERI-------PWIAPECVEDSKNLSVAAD 219 Query: 228 IWSVGCILAEM-LSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPS 286 WS G L E+ + K ++ K R Y Sbjct: 220 KWSFGTTLWEICYNGEIPLKDKTLIE-----------------------KERFY------ 250 Query: 287 KTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 + + P A DL+ R + ++PN+R + Sbjct: 251 --ESRCRPVTPSCKELA-DLMTRCMNYDPNQRPFFRAIMR 287 >2C47-A nrPDB Length = 313 Score = 111 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 48/285 (16%), Positives = 96/285 (33%), Gaps = 23/285 (8%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 GP + + IG G +G + + VAIK + P ++ + E + + Sbjct: 3 GPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPI--KSRAPQLHLEYRFYKQLSAT 59 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKL--LKSQQLSNDHICYFLYQILRGLKY 156 + +V +L+ L L L + + + Q++ ++Y Sbjct: 60 EGVPQVYYFGPCGKYNA----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEY 115 Query: 157 IHSANVLHRDLKPSNLLINTTCD-----LKICDFGLARIADPEHDHTGFL----TEYVAT 207 +H+ ++++RD+KP N L+ + I DFGLA+ T Sbjct: 116 VHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGT 175 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG---KHYLDQLNHILGILGSP 264 Y + L + ++ D+ ++G + L + G ++ I + Sbjct: 176 ARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRAT 234 Query: 265 SQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDR 309 E L + YL+ + + DL DR Sbjct: 235 PIEVLCENFPEEMATYLR-YVRRLDFFEKPDYDYLRKLFTDLFDR 278 >2CMW-A nrPDB Length = 310 Score = 111 bits (278), Expect = 5e-25, Method: Composition-based stats. Identities = 49/281 (17%), Positives = 97/281 (34%), Gaps = 22/281 (7%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 + IG G +G + + VAIK + P ++ + E + + G Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPI--KSRAPQLHLEYRFYKQLGSAG-EG 58 Query: 103 IRDILRASTLEAMRDVYIVQDLMETDLYKL--LKSQQLSNDHICYFLYQILRGLKYIHSA 160 + + +V +L+ L L L + + + Q+L ++Y+HS Sbjct: 59 LPQVYYFGPCGKYNA--MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSK 116 Query: 161 NVLHRDLKPSNLLINTTCD-----LKICDFGLARIADPEHDHTGFL----TEYVATRWYR 211 N+++RD+KP N LI + + I DFGLA+ T Y Sbjct: 117 NLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 176 Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG---KHYLDQLNHILGILGSPSQED 268 + L + ++ D+ ++G + L + G ++ I + E Sbjct: 177 SINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEA 235 Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDR 309 L + YL+ + + + DL ++ Sbjct: 236 LCENFPEEMATYLR-YVRRLDFFEKPDYEYLRTLFTDLFEK 275 >5USZ-A nrPDB Length = 289 Score = 111 bits (278), Expect = 5e-25, Method: Composition-based stats. Identities = 42/293 (14%), Positives = 99/293 (33%), Gaps = 62/293 (21%) Query: 46 QYIGEGAYGMVSSAYDHVRK-------TRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 + +G+G + + T V +K + H+ Y + ++ + H+ Sbjct: 14 ESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDK-AHRNYSESFFEAASMMSKLSHK 72 Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQ--LSNDHICYFLYQILRGLK 155 +++ + +VQ+ ++ L LK + ++ Q+ + Sbjct: 73 HLVLNYGVCVCGDENI-----LVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAAAMH 127 Query: 156 YIHSANVLHRDLKPSNLLINTTCD--------LKICDFGLARIADPEHDHTGFLTEYVAT 207 ++ ++H ++ N+L+ D +K+ D G++ P+ L E + Sbjct: 128 FLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKD----ILQERIP- 182 Query: 208 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 267 + PE + N K + D WS G L E+ S G Sbjct: 183 --WVPPECIENPKNLNLATDKWSFGTTLWEICSG--------------------GDKPLS 220 Query: 268 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT 320 L+ ++ LP+ ++ +L++ + + P+ R + Sbjct: 221 ALDSQRKLQFYEDRHQLPAPKA-----------AELANLINNCMDYEPDHRPS 262 >4XHH-A nrPDB Length = 403 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 52/285 (18%), Positives = 105/285 (36%), Gaps = 21/285 (7%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 VG ++ + IG G++G + + + VAI ++ + E ++ Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDYESRVYKYLS- 60 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILRGLK 155 +GI +R E + ++ DL+ L L ++ S + Q++ ++ Sbjct: 61 -GGVGIP-FIRWFGREGEYNAMVI-DLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQ 117 Query: 156 YIHSANVLHRDLKPSNLLIN---TTCDLKICDFGLARIADPEHDHTGFL----TEYVATR 208 YIH + +HRD+KP N L+ + + DFGL++ + H T Sbjct: 118 YIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTA 177 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG---KHYLDQLNHILGILGSPS 265 Y + L + ++ D+ S+G +L + G + + IL S Sbjct: 178 RYASVNTHLGIEQ-SRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCIS 236 Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRM 310 E L + ++ Y+ + K + DL ++ Sbjct: 237 VETLCAGLPLEFSEYM-NYCRNLKFDERPDYLYLARLFKDLSIKL 280 >5UV4-A nrPDB Length = 311 Score = 107 bits (267), Expect = 8e-24, Method: Composition-based stats. Identities = 49/207 (23%), Positives = 80/207 (38%), Gaps = 17/207 (8%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRD 105 + IG +G A + +K + + REI+ L RH N++ +R Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEG-FAKSKKEFSREIKKLGSVRHPNLVPLRG 88 Query: 106 ILRASTLEAMRDVYIVQDLME-TDLYKLLKS------QQLSNDHICYFLYQILRGLKYIH 158 + ++ D + T L L LS I R L Y+H Sbjct: 89 YYWGP---KEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLH 145 Query: 159 SANVL-HRDLKPSNLLI-NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 216 + V+ H ++K SN+LI N+T + D+ L R+ P L Y PE Sbjct: 146 NERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNA--GALGYSPPEFS 203 Query: 217 LNSKGY-TKSIDIWSVGCILAEMLSNR 242 SK + D+++ G IL E+L+ + Sbjct: 204 STSKPCPSLKSDVYAFGVILLELLTGK 230 >4XHL-A nrPDB Length = 394 Score = 106 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 48/256 (18%), Positives = 99/256 (38%), Gaps = 20/256 (7%) Query: 38 VGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH 97 VG ++ + IG G++G + + + VAI ++ + E ++ Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDYESRVYRYLS- 60 Query: 98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILRGLK 155 +GI +R E + ++ DL+ L L ++ S + Q+ ++ Sbjct: 61 -GGVGIP-FIRWFGREGEYNAMVI-DLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQ 117 Query: 156 YIHSANVLHRDLKPSNLLIN---TTCDLKICDFGLARIADPEHDHTGFL----TEYVATR 208 YIH + +HRD+KP N L+ + + DFGL++ + H T Sbjct: 118 YIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTA 177 Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG---KHYLDQLNHILGILGSPS 265 Y + L + ++ D+ S+G +L + G + + I+ + S Sbjct: 178 RYASVNTHLGIEQ-SRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVS 236 Query: 266 QEDLNCIINMKARNYL 281 E L + ++ + Y+ Sbjct: 237 VETLCSGLPLEFQEYM 252 >6EQI-C nrPDB Length = 433 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 60/347 (17%), Positives = 115/347 (33%), Gaps = 96/347 (27%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRK-----TRVAIKKISPFEHQTY----CQRTLRE----- 88 + I +G +V SA + ++A+K + ++ ++ + RE Sbjct: 18 DLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETVPAM 77 Query: 89 ----------IQILLRFR-----HENVIGIRDIL--RASTLEAMRDVY------------ 119 I+ + F+ H N++ + + R L+ + +Y Sbjct: 78 SYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRINPEG 137 Query: 120 --------IVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSN 171 +V + L + L+ + + L Q+L + +++ N+ HRDLK N Sbjct: 138 SGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLLEAVAHMNIHNISHRDLKSDN 197 Query: 172 LLINTTC-----DLKICDFGLA---RIADPEHDHTGFLTEYVATRWYRAPEIMLNSKG-- 221 +L++ + + I DFG + + + R APEI G Sbjct: 198 ILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIANAKPGTF 257 Query: 222 ----YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 277 Y K D+W+VG I E+ + F K + + Sbjct: 258 SWLNY-KKSDLWAVGAIAYEIFNIDNPFYDKT-------------------MKLLSKSYK 297 Query: 278 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 L LP +L+ ML+ + NKR+ + A Sbjct: 298 EEDLPELPD-----------TIPFIIRNLVSNMLSRSTNKRLDCDVA 333 >3REP-A nrPDB Length = 271 Score = 99.7 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 41/273 (15%), Positives = 84/273 (30%), Gaps = 47/273 (17%) Query: 54 GMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLE 113 G + V + K+ + + E L F H NV+ + ++ Sbjct: 24 GELWKGRWQGNDIVVKVLKVRDWSTRKSR-DFNEECPRLRIFSHPNVLPVLGACQSP--P 80 Query: 114 AMRDVYIVQDLMETDLYKLLKSQQ---LSNDHICYFLYQILRGLKYIHSAN-VLHR-DLK 168 A I + LY +L + F + RG+ ++H+ ++ R L Sbjct: 81 APHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALN 140 Query: 169 PSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT--KSI 226 +++I+ ARI+ + + + + APE + T +S Sbjct: 141 SRSVMIDEDMT--------ARISMADVKFSFQSPGRMYAPAWVAPEALQKKPEDTNRRSA 192 Query: 227 DIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPS 286 D+WS +L E+++ F ++ + P+ Sbjct: 193 DMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPT--------------------- 231 Query: 287 KTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRI 319 + P L+ + +P KR Sbjct: 232 --------IPPGISPHVSKLMKICMNEDPAKRP 256 >4I94-A nrPDB Length = 300 Score = 96.2 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 41/266 (15%), Positives = 92/266 (34%), Gaps = 37/266 (13%) Query: 55 MVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEA 114 +V + R+A+K+ + Q L E + + + R+ + + Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWPDSRQ-FLEEAKAVGQLRNHRMANLLGCCYEDEERL 101 Query: 115 MRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSAN-VLHRDLKPSNLL 173 + ++ + + L+ +SQ + I + L+Y S L+ DL +L Sbjct: 102 LIAEFMPNETLAKHLFH-WESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRVL 160 Query: 174 INTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGC 233 + + ++ FGL + + ++ L + PE + + +S+ I+S G Sbjct: 161 FDDDANPRLSCFGLMKNSRDGKSYSTNL-------AFTPPEYLRTGRVTPESV-IYSFGT 212 Query: 234 ILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWA 293 +L ++LS + I P + + +L E Sbjct: 213 LLLDLLSGKHIPPSHALDLIRDRNIQMLMDSGLE-------------------------G 247 Query: 294 KLFPKSDSKALDLLDRMLTFNPNKRI 319 + ++ + L R L + P +R Sbjct: 248 QFSSDDGTELIRLASRCLQYEPRERP 273 >5C01-A nrPDB Length = 342 Score = 95.4 bits (236), Expect = 3e-20, Method: Composition-based stats. Identities = 38/279 (13%), Positives = 87/279 (31%), Gaps = 55/279 (19%) Query: 59 AYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDV 118 D ++ RV +K + P H ++ + H ++ + + + ++ Sbjct: 101 GRDRGQELRVVLKVLDP-SHHDIALAFYETASLMSQVSHTHLAFVHGVC----VRGPENI 155 Query: 119 YIVQDLMETDLYKLLKSQQ--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLI-- 174 + + + L L+ ++ + Q+ L Y+ + N++H ++ N+L+ Sbjct: 156 MVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLAR 215 Query: 175 -----NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS-KGYTKSIDI 228 T+ +K+ D G+ A + + + APE + + ++D Sbjct: 216 LGLAEGTSPFIKLSDPGVGLGALSREERVERI-------PWLAPECLPGGANSLSTAMDK 268 Query: 229 WSVGCILAEM-LSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSK 287 W G L E+ + + LP Sbjct: 269 WGFGATLLEICFDGEAPLQSRSPSE---------------------KEHFYQRQHRLPEP 307 Query: 288 TKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 + A L + LT+ P +R + L Sbjct: 308 SCPQLAT-----------LTSQCLTYEPTQRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 95.0 bits (235), Expect = 5e-20, Method: Composition-based stats. Identities = 38/279 (13%), Positives = 87/279 (31%), Gaps = 55/279 (19%) Query: 59 AYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDV 118 D ++ RV +K + P H ++ + H ++ + + + ++ Sbjct: 78 GRDRGQELRVVLKVLDP-SHHDIALAFYETASLMSQVSHTHLAFVHGVC----VRGPENI 132 Query: 119 YIVQDLMETDLYKLLKSQQ--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLI-- 174 + + + L L+ ++ + Q+ L Y+ + N++H ++ N+L+ Sbjct: 133 MVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLAR 192 Query: 175 -----NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS-KGYTKSIDI 228 T+ +K+ D G+ A + + + APE + + ++D Sbjct: 193 LGLAEGTSPFIKLSDPGVGLGALSREERVERI-------PWLAPECLPGGANSLSTAMDK 245 Query: 229 WSVGCILAEM-LSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSK 287 W G L E+ + + LP Sbjct: 246 WGFGATLLEICFDGEAPLQSRSPSE---------------------KEHFYQRQHRLPEP 284 Query: 288 TKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 + A L + LT+ P +R + L Sbjct: 285 SCPQLAT-----------LTSQCLTYEPTQRPSFRTILR 312 >6J6I-B nrPDB Length = 351 Score = 93.5 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 34/200 (17%), Positives = 72/200 (36%), Gaps = 25/200 (12%) Query: 60 YDHVRKTRVAIKKISPFEHQTYCQRTLREIQ---IL--LRFRHENVIGIRDILRASTLEA 114 + IK+ S E R +E+ +L H N + + Sbjct: 76 RGEIEDRSYMIKRFSEDEITGKRHRV-KEVYNDIVLSARMSNHSNFLQLLGCCLEFPFP- 133 Query: 115 MRDVYIVQDLMETDLYK-----LLKSQQ--LSNDHICYFLYQILRGLKYIHS---ANVLH 164 +V + E ++ ++ L +I + Y+H+ ++H Sbjct: 134 ----VLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIH 189 Query: 165 RDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY-T 223 RD+KP ++ ++ K+ D + I+ PE + T Y P + + + T Sbjct: 190 RDVKPMHVFLDKNWTAKLSDLSFS-ISLPEGKSRIEAEWVLGTFGYIDP--LYHKTCFVT 246 Query: 224 KSIDIWSVGCILAEMLSNRP 243 + D++S G L +++ +P Sbjct: 247 EYTDVYSFGICLLVIITGKP 266 >2RSV-A nrPDB Length = 403 Score = 83.1 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 56/267 (20%), Positives = 102/267 (38%), Gaps = 34/267 (12%) Query: 9 GGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGP--------RYTQLQYIGEGAYGMVSSAY 60 G G P R + G + + F VG + IG+G +G + A Sbjct: 4 GSSGMP-RVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA- 61 Query: 61 DHVRKTRV-----AIKKISP-------FEHQTYCQRTLRE-IQILLRFRHENVIGIRDIL 107 D V + K+ P E + Y + E IQ +R R +G+ Sbjct: 62 DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYW 121 Query: 108 RASTLEAMRDVY--IVQDLMETDLYKLLKS--QQLSNDHICYFLYQILRGLKYIHSANVL 163 + + Y ++ D +DL K+ ++ ++ S + +IL L+YIH + Sbjct: 122 GSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYV 181 Query: 164 HRDLKPSNLLINTTC--DLKICDFGLARIADPEHDHTGFLTE----YVATRWYRAPEIML 217 H D+K SNLL+N + + D+GLA PE H + + + T + + + Sbjct: 182 HGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHN 241 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPI 244 ++ D+ +G + + L+ Sbjct: 242 GVAP-SRRGDLEILGYCMIQWLTGHLP 267 >5UU1-A nrPDB Length = 324 Score = 81.5 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 38/231 (16%), Positives = 88/231 (38%), Gaps = 32/231 (13%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVA--IKKISPFEHQTYCQRTLREIQILLRFR 96 G ++ + IG G +G++ A+ + + A + K+ E+ E++ R Sbjct: 15 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP----LFSELKFYQRVA 70 Query: 97 HENVIG--------------IRDILRASTLEAMRDVYIVQDLMETDLYKLL-KSQQLSND 141 ++ I + + + ++V + + DL K+ ++ Sbjct: 71 KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKS 130 Query: 142 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC--DLKICDFGLARIADPEHDHTG 199 + ++L L+YIH +H D+K +NLL+ + + D+GL+ P +H Sbjct: 131 TVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQ 190 Query: 200 F----LTEYVATRWYRAPEIMLNSKG--YTKSIDIWSVGCILAEMLSNRPI 244 + + T + + + KG ++ D+ +G + L + Sbjct: 191 YQENPRKGHNGTIEFTS---LDAHKGVALSRRSDVEILGYCMLRWLCGKLP 238 >2LAV-A nrPDB Length = 361 Score = 80.0 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 56/263 (21%), Positives = 103/263 (39%), Gaps = 31/263 (11%) Query: 5 AAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVR 64 AAQ G +R V + + + + VG IG+G +G + A D Sbjct: 6 AAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGL------PIGQGGFGCIYLA-DMNS 58 Query: 65 KTRV-----AIKKISP-------FEHQTYCQRTLRE-IQILLRFRHENVIGIRDILRAST 111 V + K+ P E + Y + E IQ +R R +G+ + Sbjct: 59 SESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGL 118 Query: 112 LEAMRDVY--IVQDLMETDLYKLLKS--QQLSNDHICYFLYQILRGLKYIHSANVLHRDL 167 + Y ++ D +DL K+ ++ ++ S + +IL L+YIH +H D+ Sbjct: 119 HDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDI 178 Query: 168 KPSNLLINTTC--DLKICDFGLARIADPEHDHTGFLTE----YVATRWYRAPEIMLNSKG 221 K SNLL+N + + D+GLA PE H + + + T + + + Sbjct: 179 KASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP 238 Query: 222 YTKSIDIWSVGCILAEMLSNRPI 244 ++ D+ +G + + L+ Sbjct: 239 -SRRGDLEILGYCMIQWLTGHLP 260 >5CLR-A nrPDB Length = 451 Score = 80.0 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 30/197 (15%), Positives = 66/197 (33%), Gaps = 27/197 (13%) Query: 57 SSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMR 116 Y +K + E L + + + Sbjct: 96 FKVYALDDGKTYFLKSVKI--DAESLTEFTNEKDTLSKLG-----RLVGTFFNEQTQVH- 147 Query: 117 DVYIVQDLMET-DLYKLLKSQQLSND-----HICYFLYQILRGLKYIHSANVLHRDLKPS 170 YI+ ++ DL + + L+ + + + + +K H ++HRDLKP Sbjct: 148 --YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPG 205 Query: 171 NLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI--MLNSKGYTKSIDI 228 N++++ + DFG + + T Y APE+ + +++ D+ Sbjct: 206 NIMLDADMQCHLVDFGSSSSDKEPKPASW------GTASYLAPELNAQEDFIAFSQVSDL 259 Query: 229 WSVGCILAEMLSNRPIF 245 +++ L E+ + F Sbjct: 260 FALAYSLDELFN---PF 273 >4IX6-A nrPDB Length = 350 Score = 78.9 bits (193), Expect = 4e-15, Method: Composition-based stats. Identities = 51/334 (15%), Positives = 102/334 (30%), Gaps = 72/334 (21%) Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFR-HEN----VIG 102 +G G +G V + V + + L E ++ + + H N Sbjct: 28 LGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYHVHANAKGTCAR 83 Query: 103 IRDILRASTLEA--------MRDVYIVQDLMETD--LYKLLKSQQLSNDHICYF------ 146 + + +++ E + + L++ Sbjct: 84 FMGCIELGAKDGGEIYNGTLTEGLWL-MWANEGENTVEALMRRGTAPLATAMACADATEL 142 Query: 147 ------LYQILRGLKYIHSANVLHRDLKPSNLLINTT--CDLKICDFGLARIADPEHDHT 198 + ++L L +H V+HRD+KP+NL+ LK+ D G A + P + Sbjct: 143 GVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETL 202 Query: 199 GFLTEYVA--TRWYRAPEIMLNSKGYTKSI----------------DIWSVGCILAEMLS 240 + R+ +A E+ L G + D WS GC++ ++ Sbjct: 203 NYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLA- 261 Query: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300 ++G+ E + K+ F D Sbjct: 262 ----------------VVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALD 305 Query: 301 S---KALDLLDRMLTFNPNKRITVEEALAHPYLE 331 + DL R++ + R + E AL+H + + Sbjct: 306 ANGGAGWDLCQRLMEAERDARASCEAALSHAFFD 339 >6G4J-A nrPDB Length = 315 Score = 71.9 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 33/159 (20%), Positives = 56/159 (35%), Gaps = 25/159 (15%) Query: 39 GPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHE 98 G YT + +G+GA G+V A VA+K E+ +L F Sbjct: 25 GNTYTLRKQLGKGANGIVYLAE--TSDGHVALKV------SDDSLSITSEVNVLKSFS-- 74 Query: 99 NVIGIRDILRASTLEAMRDVYI----------VQDLMETDLYKLLKSQQLSNDHICYFLY 148 + + + D YI + ++ L S + + I + Sbjct: 75 ---KAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAE-WIPVLMI 130 Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINT-TCDLKICDFG 186 Q+L L +H + DLKP NL++ ++ D G Sbjct: 131 QLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >4CI6-B nrPDB Length = 643 Score = 70.4 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 50/316 (15%), Positives = 104/316 (32%), Gaps = 53/316 (16%) Query: 62 HVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF-----RHENVIGIRDILRASTLEAMR 116 ++ VA E E++ +H N+ + A R Sbjct: 66 KDKQRLVA-----KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHG--MAVVPYGNR 118 Query: 117 DVY-IVQDLMET--------DLYKLLKSQQLS----NDHICYFLYQILRGLKYIHSANVL 163 Y ++ D ++ L K +++ I + +++L ++ A ++ Sbjct: 119 YYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIV 178 Query: 164 HRDLKPSNLLINT-TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 222 H D+KP N++ + + + + D GL + GF T ++APE+ + + G Sbjct: 179 HNDIKPGNVVFDRASGEPVVIDLGL--HSRSGEQPKGF------TESFKAPELGVGNLGA 230 Query: 223 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ 282 ++ D++ +++ +L F + + I P+ M Y Sbjct: 231 SEKSDVF---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAH-------VMDENGYPI 280 Query: 283 SLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVA 342 P V A + +L + + R EA H +L + Sbjct: 281 HRPGIAGVETAYTR---------FITDILGVSADSRPDSNEARLHEFLSDGTIDEESAKQ 331 Query: 343 EEPFTFAMELDDLPKE 358 T E+ LP + Sbjct: 332 ILKDTLTGEMSPLPTD 347 >6EAS-A nrPDB Length = 308 Score = 69.6 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 36/254 (14%), Positives = 85/254 (33%), Gaps = 45/254 (17%) Query: 78 HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--- 134 + + ++I L + H+N + + V + + L++ L Sbjct: 81 SKENESQYRKKITNLSKVSHKNFMNLLGYCEEE--HPFTRVMVFEYAPNGTLFEHLHVRE 138 Query: 135 SQQLSNDHICYFLYQILRGLKYIHSANV--LHRDLKPSNLLINTTCDLKICDFGLARIAD 192 +++L I L+++H R+ + + + K+ D A Sbjct: 139 AEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWNDAK 198 Query: 193 PEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLD 252 + T + +P++ + Y G +L E+L+ R Sbjct: 199 GHNSTTNNELAF-------SPDMEDIVRKY---------GMVLLEILTGRVP-------- 234 Query: 253 QLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWA-KLFPKSDSKAL-DLLDRM 310 S ED + N +R + + + + + FP+ ++AL +++ Sbjct: 235 ------------SSEDDGPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARALCEVVRSC 282 Query: 311 LTFNPNKRITVEEA 324 + +P KR ++E Sbjct: 283 IDRDPKKRPQMKEV 296 >5DMZ-A nrPDB Length = 365 Score = 67.3 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 45/231 (19%), Positives = 88/231 (38%), Gaps = 22/231 (9%) Query: 30 MVKGQPFDVGPRYTQLQ-YIGEGAYGMVSSAY-----DHVRKTRVAIKKISPFEH-QTYC 82 + F +G + + +GEGA+ V A D K + +K P + Y Sbjct: 54 IKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYI 113 Query: 83 QRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQLSND 141 L E ++ +H + L + + ++Y L+ +LYK + + Sbjct: 114 GTQLME-RLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQG 172 Query: 142 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLI-----------NTTCDLKICDFGLARI 190 + F ++L ++ +H ++H D+KP N ++ + + L + D G + Sbjct: 173 LVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSID 232 Query: 191 ADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN 241 T F T T ++ E++ N K + ID + V + ML Sbjct: 233 MKLFPKGTIF-TAKCETSGFQCVEMLSN-KPWNYQIDYFGVAATVYCMLFG 281 >4O1O-A nrPDB Length = 717 Score = 66.5 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 25/128 (19%), Positives = 52/128 (40%), Gaps = 17/128 (13%) Query: 65 KTRVAIKKISPFEHQTYCQRTLREIQILLRFR-HENVIGIRDILRASTLEAMRDVYIVQD 123 VA+K+ S R +E+ L R ++NV+ + +++ Sbjct: 369 DQEVAVKRFSEGST-----RGQQEVSCLQSSRANDNVVTFYG-----SESDGSCLHVCLA 418 Query: 124 LMETDLYKLLKSQQLS------NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT 177 L E L + L + + ++ L + + + +H + H+DL+P N+LI++ Sbjct: 419 LCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSK 478 Query: 178 CDLKICDF 185 + DF Sbjct: 479 NGTFLADF 486 Score = 30.3 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 9/38 (23%), Positives = 16/38 (42%), Gaps = 4/38 (10%) Query: 298 KSDSKALDLLDRMLTF--NPNKRITVEEALAHPYLEQY 333 D + DL+ + N R++ LAHP+ + Sbjct: 536 SPDEETRDLIHHLFHPGDNVEDRLSS--LLAHPFFWSW 571 >4OAU-C nrPDB Length = 699 Score = 63.1 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 29/158 (18%), Positives = 56/158 (35%), Gaps = 24/158 (15%) Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95 F + +Y + G + + K VA+K R RE+ L Sbjct: 343 FFIDEKYKIADT----SEGGIYLGF--YEKQEVAVKTFCEGS-----PRAQREVSCLQSS 391 Query: 96 R-HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDH------ICYFLY 148 R + +++ + +++ L E L L + + L Sbjct: 392 RENSHLVTFYG-----SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLS 446 Query: 149 QILRGLKYIH-SANVLHRDLKPSNLLINTTCDLKICDF 185 I + ++ +H S H+DL+P N+LI++ + DF Sbjct: 447 SIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 484 Score = 28.8 bits (63), Expect = 4.3, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 16/36 (44%) Query: 298 KSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333 D + DL+ R+ + R + + L HP+ + Sbjct: 534 SPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTW 569 >2JII-A nrPDB Length = 352 Score = 63.1 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 22/189 (11%), Positives = 63/189 (33%), Gaps = 12/189 (6%) Query: 107 LRASTLEAMRDVYIVQDLMETDL---YKLLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 + + ++V + L + LS + ++L L+++H + Sbjct: 122 CMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYV 181 Query: 164 HRDLKPSNLLIN--TTCDLKICDFGLARIADPEHDHTGFL----TEYVATRWYRAPEIML 217 H ++ N+ ++ + + +G A P H ++ + + + + ++ Sbjct: 182 HGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHK 241 Query: 218 NSKGYTKSIDIWSVGCILAEMLSNRPIFPG--KHYLDQLNHILGILGSPSQEDLNCIINM 275 ++ D+ S+G + + L + + D + + P C + Sbjct: 242 GCGP-SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWI 300 Query: 276 KARNYLQSL 284 + LQ Sbjct: 301 RPSETLQKY 309 >6BHC-A nrPDB Length = 438 Score = 59.2 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 56/308 (18%), Positives = 93/308 (30%), Gaps = 82/308 (26%) Query: 59 AYDHVRKTRVAIKKISPFEHQTY--------CQRTLREIQILLRFRH-----ENVIGIRD 105 A D + A+K ++ Q I H N + Sbjct: 79 AKDPLNN--YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN--RLLP 134 Query: 106 ILRASTLEAMRDVYI--------VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYI 157 S + V I V D + L + KS L +C L Q+ GL+++ Sbjct: 135 WEDPSKKQRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHL 194 Query: 158 HSANVLHRDLKPSNLLI---------------------NTTCDLKICDFGLARIADPEHD 196 +V H DL+ NLL+ + L + +F A+ D Sbjct: 195 KPYHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVD 254 Query: 197 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH 256 + APEI+ ++ K D + G ++ EML Sbjct: 255 PEILRDQSR-----LAPEIITATQY--KKCDEFQTGILIYEML----------------- 290 Query: 257 ILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPN 316 L +P E+ R L +P ++ L +L NP+ Sbjct: 291 ---HLPNPFDENPELKEREYTRADLPRIPFRSPY---------SRGLQQLASCLLNPNPS 338 Query: 317 KRITVEEA 324 +RI + +A Sbjct: 339 ERILISDA 346 >5GZA-A nrPDB Length = 290 Score = 58.8 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 41/214 (19%), Positives = 71/214 (33%), Gaps = 40/214 (18%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 +++ IG+GA V + +VA +S Y L + +L + +V+ Sbjct: 28 RRVKLIGQGAVKKVYLSEWQ--GQKVA---LSVLSSDQYADDFLHGLSMLRALQSSHVVT 82 Query: 103 IRDILRASTLEAMRDVYIVQDL-METDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS-- 159 + + + + L ++T L + + S + L Y+HS Sbjct: 83 LVGVCEEDAVFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHSSP 142 Query: 160 ANV--------LHRDLKPSNLLINTTCDLKICDFGLARIADPEHD-HTGFLTEYVA---- 206 A + LH+ L S L+ + L LA D + G L Sbjct: 143 AGIRVMCDSNDLHKTL--SQFLLASDMRL------LANDLDALPEVEKGGLGVKCGHHEL 194 Query: 207 TRWYRAPEIM-----------LNSKGYTKSIDIW 229 T + APE + GY + DIW Sbjct: 195 TGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >5GZ9-A nrPDB Length = 305 Score = 58.4 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 41/218 (18%), Positives = 76/218 (34%), Gaps = 47/218 (21%) Query: 43 TQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG 102 QL+ +GEGA V + +VA+ +++ E + + L +Q+L + E+V+ Sbjct: 37 RQLKRVGEGAVKRVFLSEWKE--HKVALSRLTRLEMK---EDFLHGLQMLKSLQSEHVVT 91 Query: 103 IRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLS-------NDHICYFLYQILRGL 154 + I+ + L L ++ QLS H + + + Sbjct: 92 LVGYCEEDGT-------ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSII 144 Query: 155 KYIHSANVLHRDLKPSN--------LLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA 206 Y+H + + R + SN L+ + + D A P DH + Sbjct: 145 NYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDL----DALPLVDHDSGVLIKCG 200 Query: 207 TRW----YRAPEIMLNS-----------KGYTKSIDIW 229 R + APE + Y + +DIW Sbjct: 201 HRELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >6EWX-A nrPDB Length = 484 Score = 58.0 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 37/245 (15%), Positives = 68/245 (27%), Gaps = 76/245 (31%) Query: 123 DLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC---- 178 D + + ++ +C+ L Q+ GL+++ ++HRDL NLL+ Sbjct: 192 DFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSS 251 Query: 179 -------------------------------------DLKICDFGLARIADPEHDHTGFL 201 L I +F A+ + Sbjct: 252 PGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQK 311 Query: 202 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 261 APEI+ S+ + D + G ++ E+L F Sbjct: 312 KSQAR----LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPF---------------- 349 Query: 262 GSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 321 ++ R+Y + + L +L +P KRI + Sbjct: 350 --------EVRAQLRERDY-----RREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRI 396 Query: 322 EEALA 326 EA Sbjct: 397 GEAKR 401 >3ENH-A nrPDB Length = 540 Score = 58.0 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 33/158 (20%), Positives = 60/158 (37%), Gaps = 12/158 (7%) Query: 46 QYIGEGAYGMVSSAYDHVRKTRVAIK-KISPFEHQTYCQRTLREIQILLRFRHENVIGIR 104 IG+GA + D V IK ++ +R+ + R+ ++ Sbjct: 342 HLIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDF 399 Query: 105 DILRASTLE-AMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVL 163 I + + + I+ + L K + L Y+I + +H +V+ Sbjct: 400 GIPAPYIFDVDLDNKRIMMSYINGKLAKDVIEDNLD------IAYKIGEIVGKLHKNDVI 453 Query: 164 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFL 201 H DL SN + + L I DFGL +I++ + D L Sbjct: 454 HNDLTTSNFIFDKD--LYIIDFGLGKISNLDEDKAVDL 489 >4CYJ-A nrPDB Length = 438 Score = 57.7 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 22/148 (14%), Positives = 53/148 (35%), Gaps = 21/148 (14%) Query: 53 YGM---VSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRA 109 +G V A + A++++ T + L ++ + ++ +++ I ++ Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRL-EGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTT 123 Query: 110 STLEAMRDVYIVQDLMETDLYKLLKSQQL--------------SNDHICYFLYQILRGLK 155 ++ L K L+ + I ++ QI LK Sbjct: 124 REFGDSS---LIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALK 180 Query: 156 YIHSANVLHRDLKPSNLLINTTCDLKIC 183 IHS + R L+PS +++ +++ Sbjct: 181 TIHSNRLAARCLEPSKIILTDINRIRLS 208 >6M7Z-A nrPDB Length = 319 Score = 56.5 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 43/242 (17%), Positives = 77/242 (31%), Gaps = 56/242 (23%) Query: 119 YIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC 178 YI L + + +L++ + S+ + ++ LK +H+ +LHR ++ ++ + Sbjct: 123 YIFHPLSKGLVGDMLETGR-SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDG 181 Query: 179 DLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI--------MLNSKGYTKSIDIWS 230 + + A P T + APEI L +T D++S Sbjct: 182 TVVLGGLDTAA---PIGTETRLWVGFFGQE--TAPEIDRNFLADLALTQGRHTVKSDVYS 236 Query: 231 VGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKV 290 +G L +LG G+ ED + Sbjct: 237 LGV----------------AFRNLVQLLGN-GNLGPEDRGAVRQDHL------------- 266 Query: 291 AWAKLFPKSDSKALD-LLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFA 349 + LD L +M+ P R T+EE + P E E PF + Sbjct: 267 -----------ELLDKLSQKMIEEEPGNRPTIEEIMKDPLFEGLNFEDIEEGKARPFRYK 315 Query: 350 ME 351 Sbjct: 316 QN 317 >4AZW-A nrPDB Length = 471 Score = 53.0 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 43/119 (36%), Gaps = 13/119 (10%) Query: 72 KISPFEHQTYCQRTLREIQILLR----FRHENVIGIRDILRASTLEAMRDVYIVQDLMET 127 ++ E Q EI+ L + F V+ E + ++V + + Sbjct: 275 ILTAEESQRNKHELHNEIKFLTQPPAGFDAPAVLA--------HGENAQSGWLVMEKLPG 326 Query: 128 DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFG 186 L + + L +LR L + H D++P N++++ ++ DFG Sbjct: 327 RLLSDMLAAG-EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG 384 >5VE6-A nrPDB Length = 492 Score = 52.7 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 21/35 (60%) Query: 140 NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLI 174 +C+ L Q+ GL+++ ++HRDL NLL+ Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 33.0 bits (74), Expect = 0.19, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 35/116 (30%), Gaps = 31/116 (26%) Query: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270 APEI+ S+ + D + G ++ E+L F Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPF------------------------E 358 Query: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 ++ R+Y Q + L +L +P KRI + EA Sbjct: 359 VRAQLRERDYRQE-----DLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKR 409 >4AZV-A nrPDB Length = 569 Score = 52.3 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 43/119 (36%), Gaps = 13/119 (10%) Query: 72 KISPFEHQTYCQRTLREIQILLR----FRHENVIGIRDILRASTLEAMRDVYIVQDLMET 127 ++ E Q EI+ L + F V+ E + ++V + + Sbjct: 275 ILTAEESQRNKYELHNEIKFLTQPPAGFDAPAVLA--------HGENAQSGWLVMEKLPG 326 Query: 128 DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFG 186 L + + L +LR L + H D++P N++++ ++ DFG Sbjct: 327 RLLSDMLAAG-EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDFG 384 >6G38-A nrPDB Length = 357 Score = 50.3 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 41/209 (19%), Positives = 62/209 (29%), Gaps = 48/209 (22%) Query: 10 GGGEPRRTEGVGPGVPGEVEMVKGQPFD---VGPRYTQLQYIGEGAYGMVSSAYDHVRKT 66 G TE + GE PF + + + IGEG +G V T Sbjct: 8 SSGVDLGTENLYFQSMGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVF--QTIADHT 65 Query: 67 RVAIKKIS-------PFEHQTYCQRTLREIQILLRF---------RHENVIGIRDIL--- 107 VAIK I+ HQ + L EI I R E IG+ + Sbjct: 66 PVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQ 125 Query: 108 ----------------------RASTLEAMRDVYIVQDLMETDL-YKLLKSQQLSNDHIC 144 ++IV + + + ++++ S Sbjct: 126 GSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAK 185 Query: 145 YFLYQILRGLKYIH-SANVLHRDLKPSNL 172 L+Q+ L S HRDL N+ Sbjct: 186 SILHQLTASLAVAEASLRFEHRDLHWGNV 214 >6R5K-O nrPDB Length = 689 Score = 48.4 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 23/135 (17%), Positives = 52/135 (38%), Gaps = 9/135 (6%) Query: 57 SSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMR 116 + + +K++ + + + QI + N+I RDI + + + Sbjct: 311 FKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDL- 369 Query: 117 DVYIVQDLMETDL----YKLLKSQQL--SNDHICYFLYQILRGLKYIHSANV-LHRDLKP 169 + +V D L Y + + +N+++ +L Q+ + IHS N+ + L Sbjct: 370 SICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLNW 429 Query: 170 SNLLINTT-CDLKIC 183 +LI +K+ Sbjct: 430 RKVLITGDPGRIKLS 444 >4BWP-A nrPDB Length = 448 Score = 48.0 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 27/165 (16%), Positives = 52/165 (31%), Gaps = 40/165 (24%) Query: 57 SSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMR 116 A + + +++I F Q+ TL +++ + +H NV+ +R++ Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTL--VEMWKKLQHTNVVQLREVFTTKAF-GDN 123 Query: 117 DVYIVQDLMETD---LYKLL------------------------------KSQQLSNDHI 143 + +V D L K L I Sbjct: 124 SLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATI 183 Query: 144 CYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT----CDLKICD 184 + Q+ GLK IH A + + L P+ +++ I D Sbjct: 184 WSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >4XR7-L nrPDB Length = 465 Score = 48.0 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 23/135 (17%), Positives = 52/135 (38%), Gaps = 9/135 (6%) Query: 57 SSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMR 116 + + +K++ + + + QI + N+I RDI + + + Sbjct: 87 FKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDL- 145 Query: 117 DVYIVQDLMETDL----YKLLKSQQL--SNDHICYFLYQILRGLKYIHSANV-LHRDLKP 169 + +V D L Y + + +N+++ +L Q+ + IHS N+ + L Sbjct: 146 SICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLNW 205 Query: 170 SNLLINTT-CDLKIC 183 +LI +K+ Sbjct: 206 RKVLITGDPGRIKLS 220 >4CZY-B nrPDB Length = 429 Score = 42.3 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 16/141 (11%), Positives = 50/141 (35%), Gaps = 18/141 (12%) Query: 57 SSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEA 114 A ++ A+++I ++ +E + + N++ + + Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKEW---KKIINANIVTVHEAFTTEFFGD 117 Query: 115 MRDVYIV-----------QDLMETDLYKLLKS-QQLSNDHICYFLYQILRGLKYIHSANV 162 +++ + + L++ ++ + + ++ QI L IH+A + Sbjct: 118 SSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKL 177 Query: 163 LHRDLKPSNLLINTTCDLKIC 183 R L+ S + I +++ Sbjct: 178 AARCLELSKI-IWENNRIRLA 197 >3BYV-A nrPDB Length = 377 Score = 42.3 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 17/103 (16%), Positives = 37/103 (35%), Gaps = 17/103 (16%) Query: 144 CYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE 203 Q++R L +H ++H L+P +++++ + + F G Sbjct: 209 LQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF-------EHLVRDGARVV 261 Query: 204 YVATRWYRAPEIMLNSKGY----------TKSIDIWSVGCILA 236 +R + PE+ T S D W++G ++ Sbjct: 262 SSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIY 304 >3Q60-A nrPDB Length = 371 Score = 41.1 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 33/194 (17%), Positives = 58/194 (29%), Gaps = 29/194 (14%) Query: 146 FLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYV 205 Q++R + S ++H P NL I L + D Sbjct: 199 LTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD------VSALWKVGTRGPASS 252 Query: 206 ATRWYRAPEIMLNSKG-YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP 264 Y E + S +T +++ W +G + + F L +P Sbjct: 253 VPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFG--------------LVTP 298 Query: 265 SQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEA 324 I + +P +A+ P D L+ R L F+ +R+ EA Sbjct: 299 G-------IKGSWKRPSLRVPGTDSLAFGSCTPLPDFV-KTLIGRFLNFDRRRRLLPLEA 350 Query: 325 LAHPYLEQYYDPTD 338 + P Q + Sbjct: 351 METPEFLQLQNEIS 364 >4WWA-A nrPDB Length = 261 Score = 40.7 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 31/183 (16%), Positives = 60/183 (32%), Gaps = 34/183 (18%) Query: 48 IGEGAYGMV-------SSAYDHVRKTRVAIK-------KISPFEHQTYCQRTLREIQILL 93 I +GA +V + IK + + RTL E ++L Sbjct: 22 ISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLA 81 Query: 94 RFRHENVIGIRDILRASTLEAMRD-VYIVQDLMETDL-----------YKLLKSQQLSND 141 + I + + +I + + DL + + Q +D Sbjct: 82 KLY-----LIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSD 136 Query: 142 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTC---DLKICDFGLARIADPEHDHT 198 + L ++ R + +H + H DL SN+++ + DFGL +++ D Sbjct: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKG 196 Query: 199 GFL 201 L Sbjct: 197 VDL 199 >1TQM-A nrPDB Length = 282 Score = 39.9 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 25/158 (15%), Positives = 52/158 (32%), Gaps = 31/158 (19%) Query: 44 QLQYIGEGAYGMVSSAYDHVRKTRVAI---------KKISPFEHQTYC-------QRTLR 87 + +GEG V + Y V KK+ + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 88 EIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFL 147 E + L + + + + E ++ +L+ D +L + + + D + Sbjct: 154 EFRALQKLQ------GLAVPKVYAWEGNA---VLMELI--DAKELYRVRVENPDEVLDM- 201 Query: 148 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDF 185 IL + + ++H DL N+L++ + I DF Sbjct: 202 --ILEEVAKFYHRGIVHGDLSQYNVLVSEEG-IWIIDF 236 >2W1Z-A nrPDB Length = 368 Score = 39.6 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 31/220 (14%), Positives = 72/220 (32%), Gaps = 24/220 (10%) Query: 69 AIKKISP----------FEHQTYCQRTLR---EIQILLRFRHENVIGIRDILRASTLEAM 115 AIK++S ++Q + LR I ++ + +I +R R + + Sbjct: 101 AIKQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVLSR 160 Query: 116 RDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY-----QILRGLKYIHSANVLHRDLKPS 170 +Y L +L S ++ + + Q++R + ++H D + Sbjct: 161 FFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVR 220 Query: 171 NLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY----TKSI 226 N+L++ + + G + + A A ++ + + T Sbjct: 221 NILLDQRGGVFLT--GFEHLVRDGASAVSPIGRGFAPPETTAERMLPYRQHHPTLMTFPF 278 Query: 227 DIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 D W++G + + L + I + Q Sbjct: 279 DTWTLGLAIYWIWCADLPNTEDAELGGIEWIYRRCKNIPQ 318 >3DZO-A nrPDB Length = 413 Score = 39.2 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 34/223 (15%), Positives = 82/223 (36%), Gaps = 30/223 (13%) Query: 69 AIKKISPFEHQTYCQRTLREIQILLRFR-HENVIGIRDILRASTLEAM-------RDVYI 120 AIK++ + R LR I+ + + H I D+++ + M RD+++ Sbjct: 121 AIKQMK---EEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWV 177 Query: 121 VQDL-----METDLY---KLLKSQQLSNDHICYFLY-----QILRGLKYIHSANVLHRDL 167 + M+++L ++L S ++ + + Q++R L +H ++H L Sbjct: 178 LSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYL 237 Query: 168 KPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY----T 223 +P +++++ + + G + + A A ++ + + T Sbjct: 238 RPVDIVLDQRGGVFLT--GFEHLVRDGASAVSPIGRGFAPPETTAERMLPFGQHHPTLMT 295 Query: 224 KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 266 + D W++G + + L I + Q Sbjct: 296 FAFDTWTLGLAIYWIWCADLPNTDDAALGGSEWIFRSCKNIPQ 338 >6FAI-l nrPDB Length = 425 Score = 36.5 bits (83), Expect = 0.019, Method: Composition-based stats. Identities = 26/167 (15%), Positives = 52/167 (31%), Gaps = 30/167 (17%) Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-ENV 100 Y+ IG G + D RV +K + R R L + N Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNR--DYLKKSNQGANW 151 Query: 101 IGIRDILRASTLEAMRDVY----------------IVQDLMETDLYKLLKSQQLSNDHIC 144 + + + + M +Y +V +L+E + L+ + Sbjct: 152 MHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYS 211 Query: 145 YFLYQILRGLKYIHSANVLHRDLKPSNLLINT------TCDLKICDF 185 + I+ + ++ ++H D N++I C + DF Sbjct: 212 DLMCFIVD----LANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >5YK0-A nrPDB Length = 452 Score = 35.7 bits (81), Expect = 0.033, Method: Composition-based stats. Identities = 24/169 (14%), Positives = 43/169 (25%), Gaps = 39/169 (23%) Query: 54 GMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLR-------------------------- 87 G V A VA+K P + Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 88 --EIQILLRFRHENVIGIRDILRASTLEAMRDVY------IVQDLMETDLYKLLKSQQLS 139 E+++ R N + V ++Q+ +E + + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTT 264 Query: 140 N--DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFG 186 D I L ++ ++H D P N ++ + I DFG Sbjct: 265 EQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >4ZO4-A nrPDB Length = 204 Score = 33.8 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 31/76 (40%) Query: 69 AIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETD 128 A K + F H + L ++QIL + + I + E + V ++ E Sbjct: 84 AKKILENFTHPKIRAKILEQMQILDKENKAFFVEIPLFFESGAYENLGKVIVIYTPKELS 143 Query: 129 LYKLLKSQQLSNDHIC 144 L ++++ +LS + Sbjct: 144 LKRIMQRDKLSLEAAK 159 >6G18-v nrPDB Length = 552 Score = 33.8 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 11/66 (16%), Positives = 30/66 (45%), Gaps = 4/66 (6%) Query: 120 IVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD 179 +V +L+ Y L + + + Y + + + + + ++H D NL+++ + Sbjct: 186 VVMELING--YPLCQIHHVEDPASVY--DEAMELIVKLANHGLIHGDFNEFNLILDESDH 241 Query: 180 LKICDF 185 + + DF Sbjct: 242 ITMIDF 247 >4FDJ-A nrPDB Length = 502 Score = 33.0 bits (74), Expect = 0.19, Method: Composition-based stats. Identities = 33/142 (23%), Positives = 49/142 (34%), Gaps = 29/142 (20%) Query: 213 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF-PGKHYLDQLNHILGILGSPSQEDLNC 271 PE++ + +K + W +G +RP F P KH D+ P Sbjct: 99 PELLKKAGYVSKIVGKWHLG--------HRPQFHPLKHGFDEWFGSPNCHFGPYDNKARP 150 Query: 272 IINM-----KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALA 326 I + Y + P K A L +ALD + R +A Sbjct: 151 NIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKR-------------QARH 197 Query: 327 HPYLEQY-YDPTDEPV-AEEPF 346 HP+ + D T PV A +PF Sbjct: 198 HPFFLYWAVDATHAPVYASKPF 219 >6FDN-A nrPDB Length = 320 Score = 33.0 bits (74), Expect = 0.20, Method: Composition-based stats. Identities = 11/66 (16%), Positives = 30/66 (45%), Gaps = 4/66 (6%) Query: 120 IVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCD 179 +V +L+ Y L + + + Y + + + + + ++H D NL+++ + Sbjct: 186 VVMELING--YPLCQIHHVEDPASVY--DEAMELIVKLANHGLIHGDFNEFNLILDESDH 241 Query: 180 LKICDF 185 + + DF Sbjct: 242 ITMIDF 247 >4BVU-A nrPDB Length = 211 Score = 32.6 bits (73), Expect = 0.32, Method: Composition-based stats. Identities = 20/145 (13%), Positives = 50/145 (34%), Gaps = 18/145 (12%) Query: 44 QLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQ--TYCQRTLREIQILLRFRHENVI 101 + IG+G+ + + KK +Q + +E ++ Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY---KKYDLIGNQYNEILEMAWQESELFN-------- 92 Query: 102 GIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSAN 161 + ++ DVY+ + + + + ++ +L I + ++ + Sbjct: 93 AFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICK----LNELS 148 Query: 162 VLHRDLKPSNLLINTTCD-LKICDF 185 ++H DL N+L + + L DF Sbjct: 149 IIHYDLNTGNMLYDKESESLFPIDF 173 >6GL3-A nrPDB Length = 386 Score = 32.2 bits (72), Expect = 0.41, Method: Composition-based stats. Identities = 30/190 (15%), Positives = 61/190 (32%), Gaps = 34/190 (17%) Query: 13 EPRRTEGVGPGVPGEVE-----MVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTR 67 R G G + + + +G P+ P + L I D +R+ Sbjct: 110 STRSDSGDGSALKEPWQEKVRRIREGSPYGHLPNWRLLSVI--------VKCGDDLRQEL 161 Query: 68 VA---IKKISPFEHQTYCQRTLREIQILLRFRHE-------NVIGIRDILRASTLEAMRD 117 +A +K++ Q ++ +IL+ N + I + + S L + Sbjct: 162 LAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLD- 220 Query: 118 VYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT 177 Y +Q+ L +Q+ + + Y+ H N+L++ Sbjct: 221 -YFLQEHGSYTTEAFLSAQRNFVQSCAGYCL-----VCYLLQVKDRHN----GNILLDAE 270 Query: 178 CDLKICDFGL 187 + DFG Sbjct: 271 GHIIHIDFGF 280 >6BQ8-A nrPDB Length = 152 Score = 31.5 bits (70), Expect = 0.59, Method: Composition-based stats. Identities = 15/112 (13%), Positives = 41/112 (36%), Gaps = 7/112 (6%) Query: 77 EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ 136 + LR + +L + + I D L + YI+++ E + +L Sbjct: 6 ARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGD--YIIREGEEGSTFFILAKG 63 Query: 137 QLSNDHIC--YFLYQILRGL---KYIHSANVLHRDLKPSNLLINTTCDLKIC 183 ++ + Q+++ L +Y ++ D++ +N++ + Sbjct: 64 KVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLV 115 >5YSW-A nrPDB Length = 441 Score = 30.7 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 8/53 (15%), Positives = 22/53 (41%), Gaps = 4/53 (7%) Query: 314 NPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFA--MELDDLPKERLKELI 364 +P R + + HP+ ++ E + ++ + +D R ++L+ Sbjct: 92 DP--RFSSDRFQYHPWFKELSPEFRERLRDDKARAGSFINMDPPEHTRYRKLL 142 >6EF6-A nrPDB Length = 354 Score = 30.3 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 18/28 (64%), Gaps = 3/28 (10%) Query: 161 NVLHRDLKPSNLLINTTC---DLKICDF 185 ++H DL+ +NLL++++ + + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >5A08-A nrPDB Length = 434 Score = 30.3 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 18/116 (15%), Positives = 40/116 (34%), Gaps = 16/116 (13%) Query: 257 ILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPN 316 IL ++ + ED+ I Y ++ + F + D + +L P Sbjct: 107 ILSLVRNSDLEDIISSIQQLEEEYNKNFGYPYTFLNDEEF---TDEFKDGIKSIL---PK 160 Query: 317 KRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQ 372 R+ + D + P + + + E+D + KE ++ + E + Sbjct: 161 DRVV-------EFGTIGPDNWNMPDSIDRERYDQEMDKMSKENIQ---YAEVESYH 206 >4ESA-B nrPDB Length = 146 Score = 29.9 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 10/49 (20%), Positives = 21/49 (42%), Gaps = 7/49 (14%) Query: 51 GAYGMVSSAYDHVRKTRVA---IKKI----SPFEHQTYCQRTLREIQIL 92 G++G + +A + +VA IK + ++ + E+ IL Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSIL 91 >4S1W-A nrPDB Length = 358 Score = 29.5 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 19/81 (23%), Positives = 30/81 (37%), Gaps = 12/81 (14%) Query: 98 ENV-IGIRDILRASTLEAMRDVYIVQDLME--TDLYKLLKSQQLSNDHICYFLYQILRGL 154 ENV + IR ++ I + +E D Y + +L + Q++ Sbjct: 277 ENVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYY 336 Query: 155 KYIHSANVLHRDL---KPSNL 172 + HRDL KP NL Sbjct: 337 AAL------HRDLDVDKPRNL 351 >5LJ3-H nrPDB Length = 591 Score = 29.2 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 28/63 (44%), Gaps = 6/63 (9%) Query: 131 KLLKSQQLSNDHICYFLYQILR--GLKYIHSANVLHRDLKPSNLLINTTCDLK-ICDFGL 187 + +K Q+ + + I + I+ + + + HRDL N+LI K + DF L Sbjct: 9 EDIKFQRENWEMIRSHVSPIISNLTMDNLQES---HRDLFQVNILIGRDIICKNVVDFTL 65 Query: 188 ARI 190 + Sbjct: 66 NKQ 68 >5YJJ-A nrPDB Length = 713 Score = 28.8 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 34/143 (23%), Positives = 54/143 (37%), Gaps = 32/143 (22%) Query: 237 EMLSNRPIFPGKHYLDQL----NHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAW 292 EML IF G + +L I+ + QE + + ++SL Sbjct: 212 EML--EAIFFGHEEIKRLVAFQQEIIDHIQPIKQEFVPVERDEDLVEKVKSL-------- 261 Query: 293 AKLFPKSDSKALDLLDRMLTFNPNKR---ITV--EEALAHPYLEQYYDPTDEPVAEEPFT 347 D D + LTF+ +R + EE + H DP +E + +E + Sbjct: 262 -----TEDKGLKDTV---LTFDKQQRDENLDALKEEVVGH--FLDEEDPENETLVKEVYA 311 Query: 348 FAMELDDLPKERLKELIFQETAR 370 L+DL KE ++ LI E R Sbjct: 312 I---LNDLIKEEVRRLIADEKIR 331 >4R7B-A nrPDB Length = 309 Score = 28.4 bits (62), Expect = 5.1, Method: Composition-based stats. Identities = 10/34 (29%), Positives = 16/34 (47%) Query: 163 LHRDLKPSNLLINTTCDLKICDFGLARIADPEHD 196 H DL P N + + L + D+ + + DP D Sbjct: 193 CHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWD 226 >6DFL-A nrPDB Length = 259 Score = 28.4 bits (62), Expect = 5.3, Method: Composition-based stats. Identities = 32/196 (16%), Positives = 60/196 (30%), Gaps = 22/196 (11%) Query: 26 GEVEMVKGQPFDVGPRYTQLQYI-----GEGAYGMVSSAYDHVRKTRVAIKKISPFEHQT 80 E V+ V + + G G + + +A K + + Sbjct: 17 DPFEAVEALQGKVYRELEGRRTLRTEVDGRGYFVKIHRGIG---WGEIA-K--NLLTAKL 70 Query: 81 YCQRTLREIQILLRFRHENV--IGIRDILRASTLEAMRDVYIVQDLMET--DLYKL---L 133 +E Q + R V + + A + +IV + + DL Sbjct: 71 PVLGARQEWQAIRRLHEAGVATMTAVAYGERGSDPARQHSFIVTEELAPTVDLEVFSQDW 130 Query: 134 KSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADP 193 + + + + R + +H A V HRD + L++T + DF L+ I Sbjct: 131 RERPPPPRLKRALVEAVARMVGDMHRAGVNHRDCYICHFLLHTDKPVSADDFRLSVI--- 187 Query: 194 EHDHTGFLTEYVATRW 209 H + RW Sbjct: 188 -DLHRAQTRDATPKRW 202 >4H05-A nrPDB Length = 273 Score = 28.4 bits (62), Expect = 5.5, Method: Composition-based stats. Identities = 11/27 (40%), Positives = 17/27 (62%), Gaps = 2/27 (7%) Query: 162 VLHRDLKPSNLLIN-TTCDLK-ICDFG 186 V H DL P N+L++ TC++ + D G Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVG 212 >3RAC-A nrPDB Length = 373 Score = 28.4 bits (62), Expect = 6.0, Method: Composition-based stats. Identities = 17/55 (30%), Positives = 28/55 (50%) Query: 264 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKR 318 P D I +R +L L S V + +L+ +K +DLL +LT++P +R Sbjct: 193 PRLLDALGISASLSRAFLACLTSGNYVQFRELWQLHAAKDVDLLANLLTWSPAER 247 >6IUQ-A nrPDB Length = 345 Score = 28.0 bits (61), Expect = 6.3, Method: Composition-based stats. Identities = 14/102 (13%), Positives = 31/102 (30%), Gaps = 7/102 (6%) Query: 55 MVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH--ENVIGIRDILRASTL 112 V D + + I + L E++ L H N + S Sbjct: 27 EVC---DQLDDKGYVV--IDDCFGHGWASALLEEMRWLNENDHFKPNKTQFALTQKGSDG 81 Query: 113 EAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGL 154 + ++ + E DL+ ++ + ++L+ L Sbjct: 82 KPQAFHFVKPHIFEVDLHDAALRTKVPELDALFHSTELLQAL 123 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.144 0.439 Lambda K H 0.267 0.0442 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,066,320 Number of Sequences: 36641 Number of extensions: 687593 Number of successful extensions: 6096 Number of sequences better than 10.0: 514 Number of HSP's better than 10.0 without gapping: 935 Number of HSP's successfully gapped in prelim test: 53 Number of HSP's that attempted gapping in prelim test: 2102 Number of HSP's gapped (non-prelim): 1256 length of query: 379 length of database: 10,336,785 effective HSP length: 99 effective length of query: 280 effective length of database: 6,709,326 effective search space: 1878611280 effective search space used: 1878611280 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 60 (27.6 bits)