BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P25929 (384 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5ZBQ-A nrPDB 741 0.0 5ZBH-A nrPDB 495 e-140 5DYS-A nrPDB 111 5e-25 2KS9-A nrPDB 111 5e-25 5WS3-A nrPDB 108 5e-24 6ME9-A nrPDB 107 7e-24 4RWA-A nrPDB 103 1e-22 4ZJC-A nrPDB 101 5e-22 5DHG-A nrPDB 101 5e-22 6B73-A nrPDB 97 2e-20 6IBL-A nrPDB 96 2e-20 4ZUD-A nrPDB 95 6e-20 6DDF-R nrPDB 94 1e-19 5W0P-A nrPDB 92 3e-19 5C1M-A nrPDB 92 3e-19 6CMO-R nrPDB 92 4e-19 5UNF-A nrPDB 92 5e-19 2VT4-A nrPDB 91 6e-19 4LDO-A nrPDB 89 2e-18 6C1Q-B nrPDB 87 9e-18 4GBR-A nrPDB 87 1e-17 4EJ4-A nrPDB 86 3e-17 5GLH-A nrPDB 85 5e-17 5GLI-A nrPDB 85 6e-17 2R4S-A nrPDB 84 1e-16 6J20-A nrPDB 84 1e-16 3SN6-R nrPDB 83 3e-16 5O9H-A nrPDB 80 1e-15 5VBL-B nrPDB 79 4e-15 6MET-B nrPDB 79 4e-15 3AYN-A nrPDB 79 4e-15 4WW3-A nrPDB 78 6e-15 5T1A-A nrPDB 78 8e-15 5XSZ-A nrPDB 77 1e-14 3PWH-A nrPDB 76 2e-14 4DJH-A nrPDB 76 3e-14 3P0G-A nrPDB 75 4e-14 6GPS-A nrPDB 75 5e-14 6GPX-A nrPDB 74 9e-14 6G79-S nrPDB 73 2e-13 4DKL-A nrPDB 72 3e-13 5V54-A nrPDB 72 3e-13 3PBL-A nrPDB 72 3e-13 4IAR-A nrPDB 72 4e-13 6GDG-A nrPDB 72 4e-13 6HLP-A nrPDB 70 2e-12 6DO1-A nrPDB 70 2e-12 4MQS-A nrPDB 69 3e-12 5UIW-A nrPDB 69 3e-12 6AKX-A nrPDB 69 4e-12 6A94-A nrPDB 68 7e-12 5LWE-A nrPDB 67 9e-12 6CM4-A nrPDB 65 4e-11 4XT3-A nrPDB 64 9e-11 6DRY-A nrPDB 64 9e-11 5WB1-A nrPDB 63 2e-10 5XJM-A nrPDB 62 4e-10 4XNV-A nrPDB 62 4e-10 2LNL-A nrPDB 62 5e-10 4U15-A nrPDB 62 5e-10 4U14-A nrPDB 62 6e-10 5CXV-A nrPDB 61 8e-10 3OE9-A nrPDB 61 9e-10 5DSG-A nrPDB 56 2e-08 6BQH-A nrPDB 56 2e-08 6N4B-R nrPDB 55 5e-08 3UON-A nrPDB 54 1e-07 3VW7-A nrPDB 54 2e-07 4BWB-A nrPDB 51 9e-07 6D26-A nrPDB 51 1e-06 5WF6-A nrPDB 50 1e-06 5NJ6-A nrPDB 50 2e-06 5NDD-A nrPDB 49 3e-06 5ZKB-A nrPDB 48 6e-06 5UVI-A nrPDB 48 7e-06 5X33-A nrPDB 47 1e-05 5ZKQ-A nrPDB 47 1e-05 5ZKP-A nrPDB 46 3e-05 5N2S-A nrPDB 45 4e-05 4BUO-A nrPDB 44 1e-04 5YWY-A nrPDB 41 8e-04 4XEE-A nrPDB 38 0.009 3V2Y-A nrPDB 37 0.013 4GRV-A nrPDB 37 0.018 5ZTY-A nrPDB 37 0.019 6D9H-R nrPDB 35 0.053 5WIV-A nrPDB 35 0.063 5U09-A nrPDB 34 0.12 3RZE-A nrPDB 33 0.21 3O8E-A nrPDB 32 0.41 3F0Y-A nrPDB 32 0.43 6M9T-A nrPDB 32 0.65 4XCS-A nrPDB 31 0.84 4NTJ-A nrPDB 31 0.94 5XRA-A nrPDB 30 1.7 6IIU-A nrPDB 30 2.0 6AK3-B nrPDB 29 3.3 3KFV-A nrPDB 29 4.1 3EXW-A nrPDB 29 4.2 6EEM-B nrPDB 29 4.4 6Q8C-A nrPDB 28 7.6 >5ZBQ-A nrPDB Length = 525 Score = 741 bits (1913), Expect = 0.0, Method: Compositional matrix adjust. Identities = 356/357 (99%), Positives = 357/357 (100%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL Sbjct: 1 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 60 Query: 62 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC 121 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC Sbjct: 61 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC 120 Query: 122 VSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTD 181 VSITVSI+SLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTD Sbjct: 121 VSITVSIWSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTD 180 Query: 182 EPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR 241 EPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR Sbjct: 181 EPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR 240 Query: 242 NNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLL 301 NNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLL Sbjct: 241 NNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLL 300 Query: 302 FLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTD 358 FLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTD Sbjct: 301 FLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTD 357 >5ZBH-A nrPDB Length = 527 Score = 495 bits (1275), Expect = e-140, Method: Compositional matrix adjust. Identities = 243/261 (93%), Positives = 249/261 (95%), Gaps = 5/261 (1%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL Sbjct: 11 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 70 Query: 62 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC 121 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC Sbjct: 71 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC 130 Query: 122 VSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTD 181 VSITVSI+SLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTD Sbjct: 131 VSITVSIWSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTD 190 Query: 182 EPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR 241 EPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR Sbjct: 191 EPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR 250 Query: 242 N-----NMMDKMRDNKYRSSE 257 N + + +R Y+ +E Sbjct: 251 NIFEMLRIDEGLRLKIYKDTE 271 Score = 234 bits (597), Expect = 4e-62, Method: Compositional matrix adjust. Identities = 109/109 (100%), Positives = 109/109 (100%) Query: 250 DNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTA 309 DNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTA Sbjct: 411 DNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTA 470 Query: 310 MISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTD 358 MISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTD Sbjct: 471 MISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTD 519 >5DYS-A nrPDB Length = 349 Score = 111 bits (278), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 91/365 (24%), Positives = 163/365 (44%), Gaps = 27/365 (7%) Query: 10 ENHSVHSNFSEKNAQLLA-FENDDCHLPLAMIFTLALAYG-AVIILGVSGNLALIIIILK 67 E + + FS K + + FE +L F++ AY +I+LG N + + ++ Sbjct: 6 EGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQ 65 Query: 68 QKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVS 127 K++R N +++NL+ +DL + +L ++VFG C L F + ++ Sbjct: 66 HKKLRTPLNYILLNLAVADLFMVFGGFTTILYTSLHGYFVFGPTGCNLEGFFATLGGEIA 125 Query: 128 IFSLVLIAVERHQLIINP-RGWRPNNRHAYVGIAVIWVLAVASSLPFLI-YQVMTDEPFQ 185 ++SLV++A+ER+ ++ P +R HA +G+A WV+A+A + P L+ + E Q Sbjct: 126 LWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQ 185 Query: 186 -NVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNM 244 + +D Y +++ S+ + V+ + PL IF CY ++ +K Sbjct: 186 CSCGIDYYTPH--------EETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQ 237 Query: 245 MDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLL 304 + + E R M++ +V+AF +CWLP + + HQ +C + + Sbjct: 238 QQESATTQKAEKEVTR---MVIIMVIAFLICWLPYAGV-AFYIFTHQ--GSCFGPIFMTI 291 Query: 305 CHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSL 364 A S NP+ Y +NK F R+ C DD + T VSKT Sbjct: 292 PAFFAKTSAVYNPVIYIMMNKQF-RNCMVTTLCCGKNPLGDDEAS-------TTVSKTET 343 Query: 365 KQASP 369 Q +P Sbjct: 344 SQVAP 348 >2KS9-A nrPDB Length = 364 Score = 111 bits (278), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 98/336 (29%), Positives = 153/336 (45%), Gaps = 14/336 (4%) Query: 36 PLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLP 95 P I A AY +++ V GN+ ++ IIL K MR VTN +VNL+F++ +A Sbjct: 28 PAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTV 87 Query: 96 FTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHA 155 F Y + + W +G CK + F ++ SI+S+ +A +R+ II+P R + Sbjct: 88 VNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATAT 147 Query: 156 YVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLS---YT 212 V I VIWVLA+ + P Y T + + VC ++P +++ Y Sbjct: 148 KVVICVIWVLALLLAFPQGYYS----------TTETMPSRVVCMIEWPEHPNKIYEKVYH 197 Query: 213 TLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAF 272 + VL YF PL I Y + I L D + S +++ M++ +V F Sbjct: 198 ICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTF 257 Query: 273 AVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQ 332 A+CWLP IF + N + ++L AM ST NPI Y LN F+ + Sbjct: 258 AICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFK 317 Query: 333 FFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQAS 368 F C F S DYE + M + ++ S+ + S Sbjct: 318 HAFRCCPFIS-AGDYEGLEMKSTRYLQTQGSVYKVS 352 >5WS3-A nrPDB Length = 560 Score = 108 bits (269), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 65/233 (27%), Positives = 117/233 (50%), Gaps = 4/233 (1%) Query: 36 PLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLP 95 P + L Y V ++ + GN+ + + + K MR VTN IVNLS +D+LV I CLP Sbjct: 57 PKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLP 116 Query: 96 FTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHA 155 T V + + W FG+++CK+ P++Q VS++VS+ +L IA++R I +P ++ + A Sbjct: 117 ATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRA 176 Query: 156 YVGIAVIWVLAVASSLP-FLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTL 214 I +IW+++ +P ++ + T P + VC +++ + + Y Sbjct: 177 RNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFT---VCDERWGGEIYPKMYHIC 233 Query: 215 LLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLS 267 ++ Y PLC + + Y +I+ +L R + + Y + LLS Sbjct: 234 FFLVTYMAPLCLMVLAYLQIFRKLWCRQGIDCSFWNESYLTGSRDERKKSLLS 286 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 24/103 (23%), Positives = 46/103 (44%), Gaps = 3/103 (2%) Query: 239 KRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNH 298 K R N + + ++ ML+ +++ FA+C+LP++I N + T + Sbjct: 444 KFRENCKKRAMSFSKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFAHTEDR 503 Query: 299 NLL---FLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFC 338 + F H ++ NPI Y FL+ F+ + + F+ C Sbjct: 504 ETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCC 546 >6ME9-A nrPDB Length = 460 Score = 107 bits (268), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 90/340 (26%), Positives = 155/340 (45%), Gaps = 64/340 (18%) Query: 43 LALAYGAVIIL----GVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTF 98 +A A AV+I+ V GNL +I+ +L+ +++RN N+ +V+L+ ++L+VA P Sbjct: 115 VAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALANLVVAFYPYPLIL 174 Query: 99 VYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNR--HAY 156 V D W FGE CK + FV +S+ S++++ IA++R+ I + + R H Sbjct: 175 VAIFYDGWAFGEEHCKASAFVMGLSVIGSVWNITAIAIDRYLYICHSMAYHRIYRRWHTP 234 Query: 157 VGIAVIWVLAVASSLP-FLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLL 215 + I +IW+L V + LP F + + D + T F Q S YT + Sbjct: 235 LHICLIWLLTVVALLPNFFVGSLEYDPRIYSCT----------FIQTAS----TQYTAAV 280 Query: 216 LVLQYFGPLCFIFICYFKIYI-----RLKRRN--------NMMDKMRDN----------- 251 +V+ + P+ + CY +I++ R+K+ N D DN Sbjct: 281 VVIHFLLPIAVVSFCYLRIWVLVLQARMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDI 340 Query: 252 ------------KYRSSETK-------RINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQI 292 K + E + R + + + V FA+C+ PL N Q Sbjct: 341 PDDWVCPLCGVGKDQFEEVECLKPSDLRSFLTMFVVFVIFAICFAPLNCIGLAVAINPQE 400 Query: 293 IATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQ 332 +A LF+ +L A ++C+NPI YG L++NF+R+ + Sbjct: 401 MAPQIPEGLFVTSYLLAYFNSCLNPIVYGLLDQNFRREYK 440 >4RWA-A nrPDB Length = 411 Score = 103 bits (256), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 91/321 (28%), Positives = 151/321 (47%), Gaps = 31/321 (9%) Query: 19 SEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNIL 78 + +NA + + LA+ + Y AV +G+ GN+ ++ I++ +M+ TNI Sbjct: 101 TTRNAYIQKYLGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIY 160 Query: 79 IVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVER 138 I NL+ +D L A LPF LM+ W FGE +CK + ++ SIF+L +++V+R Sbjct: 161 IFNLALADAL-ATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDR 219 Query: 139 HQLIINP---RGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDK 195 + + +P +R + + I IWVLA +P ++ V P Sbjct: 220 YIAVCHPVKALDFRTPAKAKLINI-CIWVLASGVGVPIMVMAVT--RPRDGAV------- 269 Query: 196 YVCFDQFPSDSHRLSYTTLLLV--LQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKY 253 VC QFPS S T + V + P+ I +CY + +RL + + +K Sbjct: 270 -VCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL----RSVRLLSGSKE 324 Query: 254 RSSETKRINIMLLSIVVAFAVCWLPLTIFNTVF-----DWNHQIIATCNHNLLFLLCHLT 308 + +RI M+L +V AF VCW P+ IF V+ D ++ H LC Sbjct: 325 KDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALH-----LCIAL 379 Query: 309 AMISTCVNPIFYGFLNKNFQR 329 ++ +NP+ Y FL++NF+R Sbjct: 380 GYANSSLNPVLYAFLDENFKR 400 >4ZJC-A nrPDB Length = 553 Score = 101 bits (252), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 108/213 (50%), Gaps = 6/213 (2%) Query: 57 GNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLN 116 GN + + + + MR VTN IVNLS +D+LV +CLP + + + + W+FG A+CK+ Sbjct: 71 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVI 130 Query: 117 PFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIY 176 P++Q VS++V++ +L IA++R I +P ++ R A I IW A SL ++ Sbjct: 131 PYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIW----AVSLAIMVP 186 Query: 177 QVMTDEPFQNVTLDAYKDKY--VCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKI 234 Q E + A + + VC +++ D + Y + ++ Y PL + + YF+I Sbjct: 187 QAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQI 246 Query: 235 YIRLKRRNNMMDKMRDNKYRSSETKRINIMLLS 267 + +L R + + Y + LLS Sbjct: 247 FRKLWGRQGIDCSFWNESYLTGSRDERKKSLLS 279 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 25/103 (24%), Positives = 44/103 (42%), Gaps = 3/103 (2%) Query: 239 KRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFN---TVFDWNHQIIAT 295 K R N + + ++ ML+ +++ FA+C+LP+++ N VF Q Sbjct: 437 KFRENCKKRAMSFSKQMRARRKTAKMLMVVLLVFALCYLPISVLNILKRVFGMFRQASDR 496 Query: 296 CNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFC 338 F H ++ NPI Y FL+ F+ + F+ C Sbjct: 497 EAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCC 539 >5DHG-A nrPDB Length = 424 Score = 101 bits (252), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 85/309 (27%), Positives = 145/309 (46%), Gaps = 25/309 (8%) Query: 35 LPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCL 94 LPL + T+ Y AV + G+ GN ++ +IL+ +M+ TNI I NL+ +D LV ++ L Sbjct: 120 LPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTL 178 Query: 95 PFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP-RGW--RPN 151 PF L+ W FG A+CK + ++ S F+L ++V+R+ I +P R R + Sbjct: 179 PFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTS 238 Query: 152 NRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPS--DSHRL 209 ++ V +A IW LA +P I E ++ C + P+ D Sbjct: 239 SKAQAVNVA-IWALASVVGVPVAIMGSAQVE----------DEEIECLVEIPTPQDYWGP 287 Query: 210 SYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIV 269 + + + + P+ I +CY + IR R ++ R+ + +RI ++L +V Sbjct: 288 VFAICIFLFSFIVPVLVISVCY-SLMIRRLRGVRLLSGSRE---KDRNLRRITRLVLVVV 343 Query: 270 VAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQR 329 F CW P+ +F Q + +L C +++C+NPI Y FL++NF+ Sbjct: 344 AVFVGCWTPVQVFVLAQGLGVQPSSETAVAIL-RFCTALGYVNSCLNPILYAFLDENFK- 401 Query: 330 DLQFFFNFC 338 F FC Sbjct: 402 --ACFRKFC 408 >6B73-A nrPDB Length = 418 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 78/302 (25%), Positives = 146/302 (48%), Gaps = 32/302 (10%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHW 106 Y V ++G+ GN ++ +I++ +M+ TNI I NL+ +D LV +PF LM+ W Sbjct: 126 YSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVT-TTMPFQSTVYLMNSW 184 Query: 107 VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP---RGWRPNNRHAYVGIAVIW 163 FG+ +CK+ + ++ SIF+L +++V+R+ + +P +R + + I IW Sbjct: 185 PFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINIC-IW 243 Query: 164 VLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHR---LSYTTLLLVLQY 220 +L+ + + ++ + D C QFP D + L + + + Sbjct: 244 LLSSSVGISAIV--------LGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAF 295 Query: 221 FGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLT 280 P+ I +CY + +RLK + + ++ + +RI ++L +V F VCW P+ Sbjct: 296 VIPVLIIIVCYTLMILRLKS----VRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIH 351 Query: 281 IFNTVFDWNHQIIATCNHNLLFL----LCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFN 336 IF V + + + +H+ L C ++ +NPI Y FL++NF+R F + Sbjct: 352 IFILV-----EALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKR---CFRD 403 Query: 337 FC 338 FC Sbjct: 404 FC 405 >6IBL-A nrPDB Length = 416 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 78/313 (24%), Positives = 154/313 (49%), Gaps = 25/313 (7%) Query: 32 DCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAI 91 D +L A ++L V++L V+GN+ +I I + ++ +TN+ I +L+ +DL+V + Sbjct: 104 DANLAEAAAKVMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGL 163 Query: 92 MCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP- 150 + +PF + W++G +C+L + + +T SI +L +IA++R+ I +P ++ Sbjct: 164 LVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL 223 Query: 151 -NNRHAYVGIAVIWVL-AVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHR 208 A V I +W + A+ S LP +++ ++P L Y+D C F ++ Sbjct: 224 MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDP---QALKCYQDPGCC--DFVTNR-- 276 Query: 209 LSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRIN----IM 264 +Y ++ ++ PL + Y ++Y K + +D R +K ++S + + Sbjct: 277 -AYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKID--RASKRKTSRVMAMKEHKALK 333 Query: 265 LLSIVVA-FAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFY--- 320 L I++ F +CWLP + N V +N ++ + LF+ + ++ +NPI Y Sbjct: 334 TLGIIMGVFTLCWLPFFLVNIVNVFNRDLV----PDWLFVAFNWLGYANSAMNPIIYCRS 389 Query: 321 GFLNKNFQRDLQF 333 K F+R L F Sbjct: 390 PDFRKAFKRLLAF 402 >4ZUD-A nrPDB Length = 410 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 87/304 (28%), Positives = 150/304 (49%), Gaps = 35/304 (11%) Query: 39 MIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTF 98 MI TL Y + ++G+ GN ++I+I +++ V ++ ++NL+ +DL ++ LP Sbjct: 125 MIPTL---YSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCF-LLTLPLWA 180 Query: 99 VYTLMDH-WVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRH--A 155 VYT M++ W FG +CK+ ++ S+F L ++++R+ I++P R A Sbjct: 181 VYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVA 240 Query: 156 YVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLL 215 V +IW+LA +SLP +I+ +NV + VC + S + L L Sbjct: 241 KVTCIIIWLLAGLASLPAIIH--------RNVFFIENTNITVCAFHYESQNSTLPIGLGL 292 Query: 216 L--VLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFA 273 +L + P I Y I+ LK+ +++ NK R+ + +I +++IV+ F Sbjct: 293 TKNILGFLFPFLIILTSYTLIWKALKKAY----EIQKNKPRNDDIFKI---IMAIVLFFF 345 Query: 274 VCWLPLTIFNTVFDWNHQ--IIATC------NHNLLFLLCHLTAMISTCVNPIFYGFLNK 325 W+P IF T D Q II C + + +C A + C+NP+FYGFL K Sbjct: 346 FSWIPHQIF-TFLDVLIQLGIIRDCRIADIVDTAMPITIC--IAYFNNCLNPLFYGFLGK 402 Query: 326 NFQR 329 F+R Sbjct: 403 KFKR 406 >6DDF-R nrPDB Length = 356 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 84/301 (27%), Positives = 145/301 (48%), Gaps = 28/301 (9%) Query: 42 TLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYT 101 T+ Y V ++G+ GN ++ +I++ +M+ TNI I NL+ +D L A LPF V Sbjct: 68 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNY 126 Query: 102 LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP---RGWRPNNRHAYVG 158 LM W FG +CK+ + ++ SIF+L ++V+R+ + +P +R R+A + Sbjct: 127 LMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFR-TPRNAKIV 185 Query: 159 IAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLL-- 216 W+L+ A LP + M ++ ++D C F SH Y LL Sbjct: 186 NVCNWILSSAIGLPVMF---MATTKYRQGSID-------CTLTF---SHPTWYWENLLKI 232 Query: 217 ---VLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFA 273 + + P+ I +CY + +RLK + + +K + +RI M+L +V F Sbjct: 233 CVFIFAFIMPVLIITVCYGLMILRLKS----VRMLSGSKEKDRNLRRITRMVLVVVAVFI 288 Query: 274 VCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQF 333 VCW P+ I+ + I T + + C ++C+NP+ Y FL++NF+R + Sbjct: 289 VCWTPIHIY-VIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFRE 347 Query: 334 F 334 F Sbjct: 348 F 348 >5W0P-A nrPDB Length = 906 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 84/346 (24%), Positives = 156/346 (45%), Gaps = 26/346 (7%) Query: 28 FENDDCHLPLAMIFTLALAYG-AVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSD 86 FE +L F++ AY +I+LG N + + ++ K++R N +++NL+ +D Sbjct: 184 FEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVAD 243 Query: 87 LLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP- 145 L + + T +L ++VFG C L F + ++++SLV++A+ER+ ++ P Sbjct: 244 LFMVLGGFTSTLYTSLHGYFVFGPTGCNLQGFFATLGGEIALWSLVVLAIERYVVVCKPM 303 Query: 146 RGWRPNNRHAYVGIAVIWVLAVASSLPFLI-YQVMTDEPFQ-NVTLDAYKDKYVCFDQFP 203 +R HA +G+A WV+A+A + P L + E Q + +D Y K Sbjct: 304 SNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLK-------- 355 Query: 204 SDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINI 263 + + S+ + V+ + P+ IF CY ++ +K + +++ K + Sbjct: 356 PEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKE---AAAQQQESATTQKAEKEVTR 412 Query: 264 MLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFL 323 M++ V+AF +CW+P + + HQ +C + + A + NP+ Y + Sbjct: 413 MVIIYVIAFLICWVPYASV-AFYIFTHQ--GSCFGPIFMTIPAFFAKSAAIYNPVIYIMM 469 Query: 324 NKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASP 369 NK F R+ C DD + VSKT Q +P Sbjct: 470 NKQF-RNCMLTTICCGKNPLGDDEAS-------ATVSKTETSQVAP 507 >5C1M-A nrPDB Length = 296 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 83/296 (28%), Positives = 143/296 (48%), Gaps = 28/296 (9%) Query: 42 TLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYT 101 T+ Y V ++G+ GN ++ +I++ +M+ TNI I NL+ +D L A LPF V Sbjct: 19 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNY 77 Query: 102 LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRG---WRPNNRHAYVG 158 LM W FG +CK+ + ++ SIF+L ++V+R+ + +P +R R+A + Sbjct: 78 LMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFR-TPRNAKIV 136 Query: 159 IAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLL-- 216 W+L+ A LP + M ++ ++D C F SH Y LL Sbjct: 137 NVCNWILSSAIGLPVMF---MATTKYRQGSID-------CTLTF---SHPTWYWENLLKI 183 Query: 217 ---VLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFA 273 + + P+ I +CY + +RLK + + +K + +RI M+L +V F Sbjct: 184 CVFIFAFIMPVLIITVCYGLMILRLKS----VRMLSGSKEKDRNLRRITRMVLVVVAVFI 239 Query: 274 VCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQR 329 VCW P+ I+ + I T + + C ++C+NP+ Y FL++NF+R Sbjct: 240 VCWTPIHIY-VIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 294 >6CMO-R nrPDB Length = 463 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 75/305 (24%), Positives = 142/305 (46%), Gaps = 18/305 (5%) Query: 28 FENDDCHLPLAMIFTLALAYG-AVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSD 86 FE +L F++ AY +I+LG N + + ++ K++R N +++NL+ +D Sbjct: 164 FEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVAD 223 Query: 87 LLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP- 145 L + + T +L ++VFG C L F + ++++SLV++A+ER+ ++ P Sbjct: 224 LFMVLGGFTSTLYTSLHGYFVFGPTGCNLQGFFATLGGEIALWSLVVLAIERYVVVCKPM 283 Query: 146 RGWRPNNRHAYVGIAVIWVLAVASSLPFLI-YQVMTDEPFQ-NVTLDAYKDKYVCFDQFP 203 +R HA +G+A WV+A+A + P L + E Q + +D Y K Sbjct: 284 SNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLK-------- 335 Query: 204 SDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINI 263 + + S+ + V+ + P+ IF CY ++ +K + + E R Sbjct: 336 PEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTR--- 392 Query: 264 MLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFL 323 M++ V+AF +CW+P + + HQ +C + + A + NP+ Y + Sbjct: 393 MVIIYVIAFLICWVPYASV-AFYIFTHQ--GSCFGPIFMTIPAFFAKSAAIYNPVIYIMM 449 Query: 324 NKNFQ 328 NK F+ Sbjct: 450 NKQFR 454 >5UNF-A nrPDB Length = 411 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 82/308 (26%), Positives = 140/308 (45%), Gaps = 32/308 (10%) Query: 42 TLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYT 101 + + Y + ++G N+ ++ + QK + V++I I NL+ +DLL+ + Y+ Sbjct: 122 AIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYS 181 Query: 102 LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP-RGWRPNNRHAYVGIA 160 W+FG MCK+ +++ SIF + ++V+R+Q +I P R N A + Sbjct: 182 YRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVP 241 Query: 161 VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLL---V 217 ++W +A SSLP F++V Y C FP + + + L + Sbjct: 242 LVWCMACLSSLPTFY--------FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNI 293 Query: 218 LQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINI--MLLSIVVAFAVC 275 L + PL FI CYF I L ++ N Y + R + M ++V+AF +C Sbjct: 294 LGFIIPLIFIATCYFGIRKHL---------LKTNSYGKNRITRDQVLKMAAAVVLAFIIC 344 Query: 276 WLPLTI--FNTVFDW-----NHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQ 328 WLP + F W + ++IA + L F + L ++CVNP Y F+ FQ Sbjct: 345 WLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAI--LLGFTNSCVNPFLYCFVGNRFQ 402 Query: 329 RDLQFFFN 336 + L+ F Sbjct: 403 QKLRSVFR 410 >2VT4-A nrPDB Length = 313 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 76/305 (24%), Positives = 150/305 (49%), Gaps = 33/305 (10%) Query: 43 LALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTL 102 ++L V++L V+GN+ +I I + ++ +TN+ I +L+ +DL+V ++ +PF + Sbjct: 14 MSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVV 73 Query: 103 MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVGIA 160 W++G +C+L + + +T SI +L +IA++R+ I +P ++ A V I Sbjct: 74 RGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIIC 133 Query: 161 VIWVL-AVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQ 219 +W + A+ S LP +++ ++P L Y+D C F ++ +Y ++ Sbjct: 134 TVWAISALVSFLPIMMHWWRDEDP---QALKCYQDPGCC--DFVTNR---AYAIASSIIS 185 Query: 220 YFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIM-------LLSIVVA- 271 ++ PL + ++Y K + +D R+S+ KR+ +M L I++ Sbjct: 186 FYIPLLIMIFVALRVYREAKEQIRKID-------RASKRKRVMLMREHKALKTLGIIMGV 238 Query: 272 FAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGF---LNKNFQ 328 F +CWLP + N V +N ++ + LF+ + ++ +NPI Y K F+ Sbjct: 239 FTLCWLPFFLVNIVNVFNRDLVP----DWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFK 294 Query: 329 RDLQF 333 R L F Sbjct: 295 RLLAF 299 >4LDO-A nrPDB Length = 469 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 71/321 (22%), Positives = 150/321 (46%), Gaps = 24/321 (7%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 S ++Q N + + + A+ D+ + + + +++ V GN+ + Sbjct: 149 KSRWYNQTPNRAKRVITTFRTGTWDAYAADE-----VWVVGMGIVMSLIVLAIVFGNVLV 203 Query: 62 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC 121 I I K + ++ VTN I +L+ +DL++ + +PF + L W FG C+ + Sbjct: 204 ITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDV 263 Query: 122 VSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVGIAVIWVLAVASSLPFLIYQVM 179 + +T SI +L +IAV+R+ I +P ++ A V I ++W+++ +S FL Q+ Sbjct: 264 LCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTS--FLPIQMH 321 Query: 180 TDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLK 239 ++ Y ++ C D F + ++ ++ + ++ ++ PL + Y +++ K Sbjct: 322 WYRATHQEAINCYAEE-TCCDFFTNQAYAIASS----IVSFYVPLVIMVFVYSRVFQEAK 376 Query: 240 RRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHN 299 R+ +DK ++++ +T I I+ F +CWLP I N V H I Sbjct: 377 RQLQKIDKFALKEHKALKTLGI------IMGTFTLCWLPFFIVNIV----HVIQDNLIRK 426 Query: 300 LLFLLCHLTAMISTCVNPIFY 320 +++L + +++ NP+ Y Sbjct: 427 EVYILLNWIGYVNSGFNPLIY 447 >6C1Q-B nrPDB Length = 422 Score = 87.4 bits (215), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 84/326 (25%), Positives = 150/326 (46%), Gaps = 44/326 (13%) Query: 19 SEKNAQLLAFENDDCHLP--LAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTN 76 + +NA + + ++ +P LA++ + V ++GV GN AL++ + + R + Sbjct: 105 TTRNAYIQKYLSNTLRVPDILALVI-----FAVVFLVGVLGN-ALVVWVTAFEAKRTINA 158 Query: 77 ILIVNLSFSDLLVAIMCLPFTFVYTLMDH-WVFGEAMCKLNPFVQCVSITVSIFSLVLIA 135 I +NL+ +D L + + LP F + H W FG A C + P + +++ SI L I+ Sbjct: 159 IWFLNLAVADFL-SCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATIS 217 Query: 136 VERHQLIINPRGWRPNNRH---AYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAY 192 +R L+ P W N R A++ AV W LA+ ++P +Y+V+ +E F Sbjct: 218 ADRFLLVFKPI-WCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYF-------- 268 Query: 193 KDKYVCFDQFPSDSHRLSYTTLL-LVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDN 251 K +C + D R ++ LVL + PL + ICY I +R R Sbjct: 269 PPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSR---------- 318 Query: 252 KYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFL-----LCH 306 R++ + + +++++V +F + WLP + + + + L L LC Sbjct: 319 --RATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMS----FLEPSSPTFLLLKKLDSLCV 372 Query: 307 LTAMISTCVNPIFYGFLNKNFQRDLQ 332 A I+ C+NPI Y + FQ L+ Sbjct: 373 SFAYINCCINPIIYVVAGQGFQGRLR 398 >4GBR-A nrPDB Length = 309 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 66/283 (23%), Positives = 138/283 (48%), Gaps = 19/283 (6%) Query: 40 IFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFV 99 + + + +++ V GN+ +I I K + ++ VTN I +L+ +DL++ + +PF Sbjct: 5 VVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAA 64 Query: 100 YTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYV 157 + L W FG C+ + + +T SI +L +IAV+R+ I +P ++ A V Sbjct: 65 HILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARV 124 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLV 217 I ++W+++ +S FL Q+ ++ Y ++ C D F + ++ ++ + + Sbjct: 125 IILMVWIVSGLTS--FLPIQMHWYRATHQEAINCYAEETCC-DFFTNQAYAIASS----I 177 Query: 218 LQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWL 277 + ++ PL + Y +++ KR+ +DK ++++ +T I I+ F +CWL Sbjct: 178 VSFYVPLVIMVFVYSRVFQEAKRQLQKIDKFCLKEHKALKTLGI------IMGTFTLCWL 231 Query: 278 PLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFY 320 P I N V H I +++L + +++ NP+ Y Sbjct: 232 PFFIVNIV----HVIQDNLIRKEVYILLNWIGYVNSGFNPLIY 270 >4EJ4-A nrPDB Length = 461 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 107/218 (49%), Gaps = 17/218 (7%) Query: 37 LAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPF 96 LA+ + Y AV +G+ GN+ ++ I++ +++ TNI I NL+ +D L A LPF Sbjct: 11 LALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADAL-ATSTLPF 69 Query: 97 TFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP---RGWRPNNR 153 LM+ W FGE +CK + ++ SIF+L +++V+R+ + +P +R + Sbjct: 70 QSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAK 129 Query: 154 HAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTT 213 + I IWVLA +P ++ V +P VC QFPS S T Sbjct: 130 AKLINIC-IWVLASGVGVPIMVMAV--TQPRDGAV--------VCMLQFPSPSWYWDTVT 178 Query: 214 LLLV--LQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + V + P+ I +CY + +RL+ N+ + +R Sbjct: 179 KICVFLFAFVVPILIITVCYGLMLLRLRSVRNIFEMLR 216 Score = 36.2 bits (82), Expect = 0.024, Method: Compositional matrix adjust. Identities = 28/85 (32%), Positives = 44/85 (51%), Gaps = 10/85 (11%) Query: 250 DNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFN---TVFDWNHQ--IIATCNHNLLFLL 304 D + +RI M+L +V AF VCW P+ IF T+ D N + ++ H L Sbjct: 367 DAYEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALH-----L 421 Query: 305 CHLTAMISTCVNPIFYGFLNKNFQR 329 C ++ +NP+ Y FL++NF+R Sbjct: 422 CIALGYANSSLNPVLYAFLDENFKR 446 >5GLH-A nrPDB Length = 498 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 52/153 (33%), Positives = 83/153 (54%), Gaps = 16/153 (10%) Query: 50 VIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFG 109 V +LG+ GN L+ II K K MRN NILI +L+ DLL ++ +P L + W FG Sbjct: 49 VFVLGIIGNSTLLYIIYKNKCMRNGPNILIASLALGDLLHIVIAIPINVYKLLAEDWPFG 108 Query: 110 EAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNN-----RHAYVGIAVIWV 164 MCKL PF+Q S+ +++ SL ++++R++ + + W + V I +IWV Sbjct: 109 AEMCKLVPFIQKASVGITVLSLCALSIDRYRAVAS---WSRIKGIGVPKWTAVEIVLIWV 165 Query: 165 LAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYV 197 ++V ++P I F +T+D YK Y+ Sbjct: 166 VSVVLAVPEAI-------GFDIITMD-YKGSYL 190 >5GLI-A nrPDB Length = 464 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 51/150 (34%), Positives = 83/150 (55%), Gaps = 10/150 (6%) Query: 50 VIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFG 109 V +LG+ GN L+ II K K MRN NILI +L+ DLL ++ +P L + W FG Sbjct: 49 VFVLGIIGNSTLLYIIYKNKCMRNGPNILIASLALGDLLHIVIAIPINVYKLLAEDWPFG 108 Query: 110 EAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNN--RHAYVGIAVIWVLAV 167 MCKL PF+Q S+ +++ SL ++++R++ + + + + V I +IWV++V Sbjct: 109 AEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSV 168 Query: 168 ASSLPFLIYQVMTDEPFQNVTLDAYKDKYV 197 ++P I F +T+D YK Y+ Sbjct: 169 VLAVPEAI-------GFDIITMD-YKGSYL 190 >2R4S-A nrPDB Length = 342 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 69/306 (22%), Positives = 141/306 (46%), Gaps = 37/306 (12%) Query: 40 IFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFV 99 + + + +++ V GN+ +I I K + ++ VTN I +L+ +DL++ + +PF Sbjct: 10 VVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAA 69 Query: 100 YTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYV 157 + LM W FG C+ + + +T SI +L +IAV+R+ I +P ++ A V Sbjct: 70 HILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARV 129 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLV 217 I ++W+++ +S FL Q+ ++ Y ++ C D F + ++ ++ + + Sbjct: 130 IILMVWIVSGLTS--FLPIQMHWYRATHQEAINCYANETCC-DFFTNQAYAIASS----I 182 Query: 218 LQYFGPLCFIFICYFKIYIRLKRRNNMMDK-----------------------MRDNKYR 254 + ++ PL + Y +++ KR+ +DK R +K+ Sbjct: 183 VSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFC 242 Query: 255 SSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTC 314 E K + + + I+ F +CWLP I N V H I +++L + +++ Sbjct: 243 LKEHKALKTLGI-IMGTFTLCWLPFFIVNIV----HVIQDNLIRKEVYILLNWIGYVNSG 297 Query: 315 VNPIFY 320 NP+ Y Sbjct: 298 FNPLIY 303 >6J20-A nrPDB Length = 441 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 65/210 (30%), Positives = 99/210 (47%), Gaps = 13/210 (6%) Query: 36 PLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLP 95 P I A AY +++ V GN+ ++ IIL K MR VTN +VNL+F++ +A Sbjct: 27 PAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFANASMAAFNTV 86 Query: 96 FTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHA 155 F Y + + W +G CK + F ++ SI+S+ +A +R+ II+P R + Sbjct: 87 VNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIWSMTAVAFDRYMAIIHPLQPRLSATAT 146 Query: 156 YVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLS---YT 212 V I VIWVLA+ + P Y P + VC ++P +++ Y Sbjct: 147 KVVICVIWVLALLLAFPQGYYSTTETMP----------SRVVCMIEWPEHPNKIYEKVYH 196 Query: 213 TLLLVLQYFGPLCFIFICYFKIYIRLKRRN 242 + VL YF PL I Y + IRL N Sbjct: 197 ICVTVLIYFLPLLVIGYAYTVVGIRLWASN 226 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/79 (35%), Positives = 36/79 (45%), Gaps = 1/79 (1%) Query: 272 FAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDL 331 FA+CWLP IF + N + ++L AM ST NPI Y LN F+ Sbjct: 363 FAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGF 422 Query: 332 QFFFNFCDFRSRDDDYETI 350 + F C F S DYE + Sbjct: 423 KHAFRCCPFIS-AGDYEGL 440 >3SN6-R nrPDB Length = 514 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 68/306 (22%), Positives = 140/306 (45%), Gaps = 37/306 (12%) Query: 40 IFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFV 99 + + + +++ V GN+ +I I K + ++ VTN I +L+ +DL++ + +PF Sbjct: 182 VVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAA 241 Query: 100 YTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYV 157 + L W FG C+ + + +T SI +L +IAV+R+ I +P ++ A V Sbjct: 242 HILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARV 301 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLV 217 I ++W+++ +S FL Q+ ++ Y ++ C D F + ++ ++ + + Sbjct: 302 IILMVWIVSGLTS--FLPIQMHWYRATHQEAINCYAEE-TCCDFFTNQAYAIASS----I 354 Query: 218 LQYFGPLCFIFICYFKIYIRLKRRNNMMDK-----------------------MRDNKYR 254 + ++ PL + Y +++ KR+ +DK R +K+ Sbjct: 355 VSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFC 414 Query: 255 SSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTC 314 E K + + + I+ F +CWLP I N V H I +++L + +++ Sbjct: 415 LKEHKALKTLGI-IMGTFTLCWLPFFIVNIV----HVIQDNLIRKEVYILLNWIGYVNSG 469 Query: 315 VNPIFY 320 NP+ Y Sbjct: 470 FNPLIY 475 >5O9H-A nrPDB Length = 317 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 79/292 (27%), Positives = 132/292 (45%), Gaps = 37/292 (12%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDH- 105 + V ++GV GN AL++ + + R + I +NL+ +D L A + LP F + H Sbjct: 15 FAVVFLVGVLGN-ALVVWVTAFEAKRTINAIWFLNLAVADFL-ACLALPALFTSIVQHHH 72 Query: 106 WVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRH---AYVGIAVI 162 W FG A C + P + +++ SI L I+ +R L+ P W R A++ AV Sbjct: 73 WPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKP-AWCQRFRGAGLAWILCAVA 131 Query: 163 WVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLL-LVLQYF 221 W LA+ ++P +Y+V+ +E F K +C + D R ++ LVL + Sbjct: 132 WGLALLLTIPSALYRVVREEYF--------PPKVLCGVDYSHDKRRERAVAIVRLVLGFL 183 Query: 222 GPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTI 281 PL + ICY I +R + RS++T ++ + +V +F + WLP + Sbjct: 184 WPLLTLTICYTFILLR---------TWSARETRSTKTLKVVVA---VVASFFIFWLPYQV 231 Query: 282 FNTVFDWNHQIIATCNHNLLFL-----LCHLTAMISTCVNPIFYGFLNKNFQ 328 + + + L L LC A I+ C+NPI Y + FQ Sbjct: 232 TGIMMS----FLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQ 279 >5VBL-B nrPDB Length = 407 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 80/334 (23%), Positives = 139/334 (41%), Gaps = 60/334 (17%) Query: 47 YGAVIILGVSGN-LALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDH 105 Y V +LG +GN L L + +E R +I I +L+ +DL + LP YT D+ Sbjct: 53 YMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVT-LPLWATYTYRDY 111 Query: 106 -WVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNR-----HAYVGI 159 W FG CKL+ ++ V++ S F L ++ +R+ I+ P N R V Sbjct: 112 DWPFGTFFCKLSSYLIFVNMYASAFCLTGLSFDRYLAIVRPVA---NARLRLRVSGAVAT 168 Query: 160 AVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLV-- 217 AV+WVLA ++P ++ + D N + Y D + + S ++ L V Sbjct: 169 AVLWVLAALLAMPVMVLRTTGDLENTN-KVQCYMD----YSMVATVSSEWAWEVGLGVSS 223 Query: 218 --LQYFGPLCFIFICYFKIY--IRLKRRN--------NMMDKMRDNKYRSS--------- 256 + + P + CYF I I +K+ N D DN Sbjct: 224 TTVGFVVPFTIMLTCYFFIAQTIAMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDD 283 Query: 257 -----------------ETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHN 299 E +R+ +++ +VV FA+C +P + T++ + C+ + Sbjct: 284 WVCPLCGVGKDQFEEVEERRRLLSIIVVLVVTFALCKMPYHLVKTLYMLGSLLHWPCDFD 343 Query: 300 L----LFLLCHLTAMISTCVNPIFYGFLNKNFQR 329 L +F C + +++C+NP Y F + F++ Sbjct: 344 LFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQ 377 >6MET-B nrPDB Length = 313 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 79/305 (25%), Positives = 139/305 (45%), Gaps = 43/305 (14%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHW 106 Y V I G GN+ +I+I++ K ++++T+I ++NL+ SDL ++ +PF + + W Sbjct: 37 YSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFF-LLTVPF-WAHYAAAQW 94 Query: 107 VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGI---AVIW 163 FG MC+L + + IF ++L+ ++R+ +++ + R G+ + W Sbjct: 95 DFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAV-FALKARTVTFGVVTSVITW 153 Query: 164 VLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRL--SYTTL-LLVLQY 220 V+AV +SLP +I+ E Y C FP ++ ++ TL +++L Sbjct: 154 VVAVFASLPGIIFTRSQKEGLH----------YTCSSHFPYSQYQFWKNFQTLKIVILGL 203 Query: 221 FGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLP-- 278 PL + ICY I L R N +K R R ++ +I++ + + W P Sbjct: 204 VLPLLVMVICYSGILKTLLRCRN--EKKRHRAVR---------LIFTIMIVYFLFWAPYN 252 Query: 279 ----LTIFNTVFDWNHQIIATCNHNLLFLLCHLT---AMISTCVNPIFYGFLNKNFQRDL 331 L F F N+ + N L +T M C+NPI Y F+ + F+ L Sbjct: 253 IVLLLNTFQEFFGLNN----CSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYL 308 Query: 332 QFFFN 336 FF Sbjct: 309 LVFFQ 313 >3AYN-A nrPDB Length = 448 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 56/231 (24%), Positives = 105/231 (45%), Gaps = 28/231 (12%) Query: 67 KQKEMRNVTNILIVNLSFSDLLVAIM-CLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSIT 125 K K ++ N+ I+NL+FSD +++ P + + W+FG A CK+ F+ + Sbjct: 61 KTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFLKKWIFGFAACKVYGFIGGIFGF 120 Query: 126 VSIFSLVLIAVERHQLIINPRGW--RPNNRHAYVGIAVIWVLAVASSL-PFLIYQVMTDE 182 +SI ++ +I+++R+ +I P + ++R A++ I +W+ +V ++ P + T E Sbjct: 121 MSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGAYTLE 180 Query: 183 PFQNVTLDAYKDKYVC---FDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLK 239 +C FD DS S + +L +FGP+ IF CYF I + + Sbjct: 181 ------------GVLCNCSFDYISRDSTTRSNILCMFILGFFGPILIIFFCYFNIVMSVS 228 Query: 240 RRNNMMDKM---------RDNKYRSSETKRINIMLLSIVVAFAVCWLPLTI 281 M M R + ++ R+ + + IV F + W P + Sbjct: 229 NHEKEMAAMAKRLNAKELRKAQAGANAEMRLAKISIVIVSQFLLSWSPYAV 279 >4WW3-A nrPDB Length = 350 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 105/228 (46%), Gaps = 22/228 (9%) Query: 67 KQKEMRNVTNILIVNLSFSDLLVAIM-CLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSIT 125 K K ++ N+ I+NL+FSD +++ P + + W+FG A CK+ F+ + Sbjct: 53 KTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFLKKWIFGFAACKVYGFIGGIFGF 112 Query: 126 VSIFSLVLIAVERHQLIINPRGW--RPNNRHAYVGIAVIWVLAVASSL-PFLIYQVMTDE 182 +SI ++ +I+++R+ +I P + ++R A++ I +W+ +V ++ P + T E Sbjct: 113 MSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGAYTLE 172 Query: 183 PFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRN 242 V + FD DS S + +L +FGP+ IF CYF I + + Sbjct: 173 ---GVLCNC------SFDYISRDSTTRSNILCMFILGFFGPILIIFFCYFNIVMSVSNHE 223 Query: 243 NMMDKM---------RDNKYRSSETKRINIMLLSIVVAFAVCWLPLTI 281 M M R + ++ R+ + + IV F + W P + Sbjct: 224 KEMAAMAKRLNAKELRKAQAGANAEMRLAKISIVIVSQFLLSWSPYAV 271 >5T1A-A nrPDB Length = 508 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 107/209 (51%), Gaps = 23/209 (11%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHW 106 Y V I G GN+ +++I++ K+++ +T+I ++NL+ SDLL ++ LP + ++ + W Sbjct: 59 YSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLF-LITLPL-WAHSAANEW 116 Query: 107 VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGI---AVIW 163 VFG AMCKL + + IF ++L+ ++R+ I++ + R G+ + W Sbjct: 117 VFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAV-FALKARTVTFGVVTSVITW 175 Query: 164 VLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP---SDSHRLSYTTLLLVLQY 220 ++AV +S+P +I+ E YVC FP ++ H + L LVL Sbjct: 176 LVAVFASVPGIIFTKCQKE----------DSVYVCGPYFPRGWNNFHTIMRNILGLVL-- 223 Query: 221 FGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 PL + ICY I K R N+ + +R Sbjct: 224 --PLLIMVICYSGISRASKSRINIFEMLR 250 Score = 32.7 bits (73), Expect = 0.28, Method: Compositional matrix adjust. Identities = 22/87 (25%), Positives = 39/87 (44%), Gaps = 8/87 (9%) Query: 255 SSETKRINIMLLSIVVAFAVCWLP------LTIFNTVFDWNHQIIATCNHNLLFLLCHLT 308 S E K + + + +I++ + + W P L F F ++ +T + + Sbjct: 407 SREKKAVRV-IFTIMIVYFLFWTPYNIVILLNTFQEFFGLSN-CESTSQLDQATQVTETL 464 Query: 309 AMISTCVNPIFYGFLNKNFQRDLQFFF 335 M C+NPI Y F+ + F+R L FF Sbjct: 465 GMTHCCINPIIYAFVGEKFRRYLSVFF 491 >5XSZ-A nrPDB Length = 477 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 66/236 (27%), Positives = 119/236 (50%), Gaps = 26/236 (11%) Query: 29 ENDDCHLPL-AMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDL 87 +ND+ PL +M+F++ V ++G+ N+A + I + ++RN T ++NL SDL Sbjct: 22 KNDNFKYPLYSMVFSI------VFMVGLITNVAAMYIFMCSLKLRNETTTYMMNLVVSDL 75 Query: 88 LVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP-- 145 L ++ LP Y + +W FG +CKL+ + ++ SI L I+V+R I+ P Sbjct: 76 LF-VLTLPLRVFYFVQQNWPFGSLLCKLSVSLFYTNMYGSILFLTCISVDRFLAIVYPFR 134 Query: 146 -RGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPS 204 RG R R+A + A +WVL ++ SLP + + + +N ++ CF+ F S Sbjct: 135 SRGLR-TKRNAKIVCAAVWVLVLSGSLP-TGFMLNSTNKLENNSIS-------CFENFSS 185 Query: 205 DSHRLSYTTLLLVLQYFG---PLCFIFICYFKIYIRLKRRN--NMMDKMR-DNKYR 254 + + +++ ++ G PL +C + L+R N N+ + +R DN R Sbjct: 186 KEWKSHLSKVVIFIETVGFLIPLMLNVVCSAMVLQTLRRPNTVNIFEMLRIDNGLR 241 >3PWH-A nrPDB Length = 329 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 78/301 (25%), Positives = 143/301 (47%), Gaps = 32/301 (10%) Query: 49 AVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVF 108 A+ +L + GN+ + + ++NVTN +V+L+ +D+LV ++ +PF T+ + Sbjct: 15 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADILVGVLAIPFAI--TISTGFC- 71 Query: 109 GEAMCKLNPFVQCVSITV---SIFSLVLIAVERHQLIINP---RGWRPNNRHAYVGIAVI 162 A C F+ C + + SIFSL+ IA++R+ I P G R A + IA+ Sbjct: 72 --AACHGCLFIACFVLVLAQSSIFSLLAIAIDRYIAIAIPLRYNGLVTGTRAAGI-IAIC 128 Query: 163 WVLAVASSLPFLIYQVMTDEP--FQNVTLDAYKDKYVC-FDQFPSDSHRLSYTTLLLVLQ 219 WVL+ A L ++ +P +N + + + C F+ ++ + + VL Sbjct: 129 WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV 188 Query: 220 YFGPLCFIFICYFKIYIRLKRRNNMMDK--MRDNKYRSSETKRINIMLLSIVVA--FAVC 275 PL + Y +I+ +R+ M+ + + RS+ K ++ + ++A FA+C Sbjct: 189 ---PLLLMLGVYLRIFAAARRQLKQMESQPLPGERARSTLQKEVHAAKSAAIIAGLFALC 245 Query: 276 WLPLTIFN--TVFDWNHQIIATCNHNLLFL--LCHLTAMISTCVNPIFYGFLNKNFQRDL 331 WLPL I N T F C+H L+L L + A ++ VNP Y + + F++ Sbjct: 246 WLPLHIINCFTFF------CPDCSHAPLWLMYLAIVLAHTNSVVNPFIYAYRIREFRQTF 299 Query: 332 Q 332 + Sbjct: 300 R 300 >4DJH-A nrPDB Length = 480 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 56/230 (24%), Positives = 109/230 (47%), Gaps = 21/230 (9%) Query: 16 SNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVT 75 + ++AQL + H+ A+ + Y V ++G+ GN ++ +I++ +M+ T Sbjct: 3 TTMGSEDAQL-----EPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTAT 57 Query: 76 NILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIA 135 NI I NL+ +D LV +PF LM+ W FG+ +CK+ + ++ SIF+L +++ Sbjct: 58 NIYIFNLALADALVT-TTMPFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMS 116 Query: 136 VERHQLIINP---RGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAY 192 V+R+ + +P +R + + I IW+L+ + + ++ + Sbjct: 117 VDRYIAVCHPVKALDFRTPLKAKIINIC-IWLLSSSVGISAIV--------LGGTKVRED 167 Query: 193 KDKYVCFDQFPSDSHR---LSYTTLLLVLQYFGPLCFIFICYFKIYIRLK 239 D C QFP D + L + + + P+ I +CY + +RLK Sbjct: 168 VDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLK 217 Score = 36.6 bits (83), Expect = 0.018, Method: Compositional matrix adjust. Identities = 33/111 (29%), Positives = 52/111 (46%), Gaps = 20/111 (18%) Query: 237 RLKR-----RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQ 291 R KR R D R+ + +RI ++L +V F VCW P+ IF V + Sbjct: 368 RAKRVITTFRTGTWDAYRE---KDRNLRRITRLVLVVVAVFVVCWTPIHIFILV-----E 419 Query: 292 IIATCNHNLLFL----LCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFC 338 + + +H+ L C ++ +NPI Y FL++NF+R F +FC Sbjct: 420 ALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKR---CFRDFC 467 >3P0G-A nrPDB Length = 501 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 50/212 (23%), Positives = 109/212 (51%), Gaps = 9/212 (4%) Query: 40 IFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFV 99 + + + +++ V GN+ +I I K + ++ VTN I +L+ +DL++ + +PF Sbjct: 41 VVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAA 100 Query: 100 YTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYV 157 + LM W FG C+ + + +T SI +L +IAV+R+ I +P ++ A V Sbjct: 101 HILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARV 160 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLV 217 I ++W+++ +S FL Q+ ++ Y ++ C D F + ++ ++ + + Sbjct: 161 IILMVWIVSGLTS--FLPIQMHWYRATHQEAINCYAEE-TCCDFFTNQAYAIASS----I 213 Query: 218 LQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + ++ PL + Y +++ KR+ N+ + +R Sbjct: 214 VSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLR 245 >6GPS-A nrPDB Length = 429 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 77/338 (22%), Positives = 144/338 (42%), Gaps = 78/338 (23%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHW 106 Y V I G GN+ +++I++ K+++ +T+I ++NL+ SDLL I LP + ++ + W Sbjct: 48 YSLVFIFGFVGNMLVVLILINYKKLKCLTDIYLLNLAISDLLFLIT-LPL-WAHSAANEW 105 Query: 107 VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGI---AVIW 163 VFG AMCKL + + IF ++L+ ++R+ I++ + R G+ + W Sbjct: 106 VFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAV-FALKARTVTFGVVTSVITW 164 Query: 164 VLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP---SDSHRLSYTTLLLVLQY 220 ++AV +S+P +I+ E YVC FP ++ H + L LVL Sbjct: 165 LVAVFASVPNIIFTKCQKE----------DSVYVCGPYFPRGWNNFHTIMRNILGLVL-- 212 Query: 221 FGPLCFIFICY---FKIYIRLKR------------------------------------- 240 PL + ICY K +R+K+ Sbjct: 213 --PLLIMVICYSGILKTLLRMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVCP 270 Query: 241 ----RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLP------LTIFNTVFDWNH 290 + +++ + K R + + ++ +I++ + + W P L F F ++ Sbjct: 271 LCGVGKDQFEEVEEEKKRHRDVR----VIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSN 326 Query: 291 QIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQ 328 +T + + M C+NPI Y F+ + F+ Sbjct: 327 -CESTSQLDQATQVTETLGMTHCCINPIIYAFVGEEFR 363 >6GPX-A nrPDB Length = 349 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 104/203 (51%), Gaps = 26/203 (12%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHW 106 Y V I G GN+ +++I++ K+++ +T+I ++NL+ SDLL I LP + ++ + W Sbjct: 21 YSLVFIFGFVGNMLVVLILINYKKLKCLTDIYLLNLAISDLLFLIT-LPL-WAHSAANEW 78 Query: 107 VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGI---AVIW 163 VFG AMCKL + + IF ++L+ ++R+ I++ + R G+ + W Sbjct: 79 VFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAV-FALKARTVTFGVVTSVITW 137 Query: 164 VLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP---SDSHRLSYTTLLLVLQY 220 ++AV +S+P +I+ E YVC FP ++ H + L LVL Sbjct: 138 LVAVFASVPNIIFTKCQKE----------DSVYVCGPYFPRGWNNFHTIMRNILGLVL-- 185 Query: 221 FGPLCFIFICY---FKIYIRLKR 240 PL + ICY K +R+K+ Sbjct: 186 --PLLIMVICYSGILKTLLRMKK 206 >6G79-S nrPDB Length = 364 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 82/374 (21%), Positives = 146/374 (39%), Gaps = 94/374 (25%) Query: 30 NDDCHLPLAMIFTLALAYGAVIILGVS-GNLALIIIILKQKEMRNVTNILIVNLSFSDLL 88 D LP ++ + LA +I L + N +I + + +++ N LI +L+ +DLL Sbjct: 9 QDSISLPWKVLLVMLLA---LITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLL 65 Query: 89 VAIMCLPFTFVYTLMDHWVFGEAMCK--LNPFVQCVSITVSIFSLVLIAVERHQLIINPR 146 V+I+ +P + +YT+ W G+ +C L+ + C T SI+ L +IA++R+ I + Sbjct: 66 VSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCC--TASIWHLCVIALDRYWAITDAV 123 Query: 147 GW--RPNNRHAYVGIAVIWVLAVASSL-PFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP 203 + + + A V IA++WV +++ SL PF Q +E + Sbjct: 124 EYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVV-------------- 169 Query: 204 SDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYI----------------RLKRRNNMMDK 247 ++ + YT V ++ P + Y +IY+ RL R + D Sbjct: 170 -NTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDS 228 Query: 248 --------------------------------------MRDNKYRSSETKRINIMLLSIV 269 + K ++ ++ L I+ Sbjct: 229 PGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIIL 288 Query: 270 VAFAVCWLPLTIFNTVFD------WNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFL 323 AF VCWLP I + V W H I + L +L ++I NPI Y Sbjct: 289 GAFIVCWLPFFIISLVMPICKDACWFHLAI----FDFFTWLGYLNSLI----NPIIYTMS 340 Query: 324 NKNFQRDLQFFFNF 337 N++F++ F Sbjct: 341 NEDFKQAFHKLIRF 354 >4DKL-A nrPDB Length = 464 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 105/216 (48%), Gaps = 23/216 (10%) Query: 42 TLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYT 101 T+ Y V ++G+ GN ++ +I++ +M+ TNI I NL+ +D L A LPF V Sbjct: 19 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNY 77 Query: 102 LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP---RGWRPNNRHAYVG 158 LM W FG +CK+ + ++ SIF+L ++V+R+ + +P +R R+A + Sbjct: 78 LMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFR-TPRNAKIV 136 Query: 159 IAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLL-- 216 W+L+ A LP + M ++ ++D C F SH Y LL Sbjct: 137 NVCNWILSSAIGLPVMF---MATTKYRQGSID-------CTLTF---SHPTWYWENLLKI 183 Query: 217 ---VLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + + P+ I +CY + +RLK N+ + +R Sbjct: 184 CVFIFAFIMPVLIITVCYGLMILRLKSVRNIFEMLR 219 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 27/89 (30%), Positives = 43/89 (48%), Gaps = 4/89 (4%) Query: 250 DNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTA 309 D + +RI M+L +V F VCW P+ I+ + I T + + C Sbjct: 370 DAYEKDRNLRRITRMVLVVVAVFIVCWTPIHIY-VIIKALITIPETTFQTVSWHFCIALG 428 Query: 310 MISTCVNPIFYGFLNKNFQRDLQFFFNFC 338 ++C+NP+ Y FL++NF+R F FC Sbjct: 429 YTNSCLNPVLYAFLDENFKR---CFREFC 454 >5V54-A nrPDB Length = 395 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 54/225 (24%), Positives = 104/225 (46%), Gaps = 23/225 (10%) Query: 30 NDDCHLPLAMIFTLALAYGAVIILGVS-GNLALIIIILKQKEMRNVTNILIVNLSFSDLL 88 D LP ++ + LA +I L + N +I + + +++ N LI +L+ +DLL Sbjct: 5 QDSISLPWKVLLVMLLA---LITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLL 61 Query: 89 VAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW 148 V+I+ +P + +YT+ W G+ +C T SI+ L +IA++R+ I + + Sbjct: 62 VSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEY 121 Query: 149 --RPNNRHAYVGIAVIWVLAVASSL-PFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSD 205 + + A V IA++WV +++ SL PF Q +E + + Sbjct: 122 SAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVV---------------N 166 Query: 206 SHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR-NNMMDKMR 249 + + YT V ++ P + Y +IY+ + R ++ D+ R Sbjct: 167 TDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIADLEDRWR 211 Score = 32.0 bits (71), Expect = 0.46, Method: Compositional matrix adjust. Identities = 27/94 (28%), Positives = 40/94 (42%), Gaps = 15/94 (15%) Query: 251 NKYRSSETKRINIMLLSIVV-AFAVCWLPLTIFNTVFD------WNHQIIATCNHNLLFL 303 KY + +R L I++ AF VCWLP I + V W H I + Sbjct: 306 QKYLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAI----FDFFTW 361 Query: 304 LCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNF 337 L +L ++I NPI Y N++F++ F Sbjct: 362 LGYLNSLI----NPIIYTMSNEDFKQAFHKLIRF 391 >3PBL-A nrPDB Length = 481 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 102/214 (47%), Gaps = 26/214 (12%) Query: 44 ALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPF-TFVYTL 102 AL+Y A+I+ V GN + + +LK++ ++ TN L+V+L+ +DLLVA + +P+ ++ Sbjct: 42 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 101 Query: 103 MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNN-----RHAYV 157 W F C + + + T SI++L I+++R+ ++ P ++ R + Sbjct: 102 GGVWNFSRICCDVFVTLDVMMCTASIWNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVAL 161 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLV 217 I +WVLA A S P L T +P VC P + V Sbjct: 162 MITAVWVLAFAVSCPLLFGFNTTGDP------------TVCSISNP------DFVIYSSV 203 Query: 218 LQYFGPLCFIFICYFKIYIRLK--RRNNMMDKMR 249 + ++ P + Y +IY+ LK RR N+ + +R Sbjct: 204 VSFYLPFGVTVLVYARIYVVLKQRRRKNIFEMLR 237 >4IAR-A nrPDB Length = 401 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 103/218 (47%), Gaps = 26/218 (11%) Query: 30 NDDCHLPLAMIFTLALAYGAVIILGVS-GNLALIIIILKQKEMRNVTNILIVNLSFSDLL 88 D LP ++ + LA +I L + N +I + + +++ N LI +L+ +DLL Sbjct: 12 QDSISLPWKVLLVMLLA---LITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLL 68 Query: 89 VAIMCLPFTFVYTLMDHWVFGEAMCK--LNPFVQCVSITVSIFSLVLIAVERHQLIINPR 146 V+I+ +P + +YT+ W G+ +C L+ + C T SI+ L +IA++R+ I + Sbjct: 69 VSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCC--TASIWHLCVIALDRYWAITDAV 126 Query: 147 GW--RPNNRHAYVGIAVIWVLAVASSL-PFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP 203 + + + A V IA++WV +++ SL PF Q +E + Sbjct: 127 EYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVV-------------- 172 Query: 204 SDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR 241 ++ + YT V ++ P + Y +IY+ + R Sbjct: 173 -NTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSR 209 Score = 34.3 bits (77), Expect = 0.092, Method: Compositional matrix adjust. Identities = 26/93 (27%), Positives = 40/93 (43%), Gaps = 14/93 (15%) Query: 251 NKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFD------WNHQIIATCNHNLLFLL 304 KY ++ ++ L I+ AF VCWLP I + V W H I + L Sbjct: 313 QKYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAI----FDFFTWL 368 Query: 305 CHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNF 337 +L ++I NPI Y N++F++ F Sbjct: 369 GYLNSLI----NPIIYTMSNEDFKQAFHKLIRF 397 >6GDG-A nrPDB Length = 479 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 77/302 (25%), Positives = 142/302 (47%), Gaps = 34/302 (11%) Query: 49 AVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVF 108 A+ +L + GN+ + + ++NVTN +V+L+ +D+ V ++ +PF T+ + Sbjct: 178 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFC- 234 Query: 109 GEAMCKLNPFVQCVSITV---SIFSLVLIAVERHQLIINP---RGWRPNNRHAYVGIAVI 162 A C F+ C + + SIFSL+ IA++R+ I P G R + IA+ Sbjct: 235 --AACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI-IAIC 291 Query: 163 WVLAVASSLPFLIYQVMTDEPFQNV--TLDAYKDKYVC-FDQFPSDSHRLSYTTLLLVLQ 219 WVL+ A L ++ +P + + + + C F+ ++ + + VL Sbjct: 292 WVLSFAIGLTPMLGWNNCGQPKEGKAHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV 351 Query: 220 YFGPLCFIFICYFKIYIRLKRRNNMMDK--MRDNKYRSSETKRINIM--LLSIVVAFAVC 275 PL + Y +I++ +R+ M+ + + RS+ K ++ L IV FA+C Sbjct: 352 ---PLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALC 408 Query: 276 WLPLTIFN--TVFDWNHQIIATCNHNLLFLLCHLTAMIS---TCVNPIFYGFLNKNFQRD 330 WLPL I N T F C+H L+L+ +L ++S + VNP Y + + F++ Sbjct: 409 WLPLHIINCFTFF------CPDCSHAPLWLM-YLAIVLSHTNSVVNPFIYAYRIREFRQT 461 Query: 331 LQ 332 + Sbjct: 462 FR 463 >6HLP-A nrPDB Length = 520 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 67/235 (28%), Positives = 107/235 (45%), Gaps = 21/235 (8%) Query: 36 PLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLP 95 P I A AY +++ V GN+ ++ IIL K MR VTN +VN +F++ +A Sbjct: 28 PAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNAAFAEASMAAFNTV 87 Query: 96 FTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHA 155 F Y + + W +G CK + F +I SI+S+ +A +R+ II+P R + Sbjct: 88 VNFTYAVHNEWYYGLFYCKFHNFFPIAAIFASIYSMTAVAFDRYMAIIHPLQPRLSLTAT 147 Query: 156 YVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLS---YT 212 V I VIWVLA+ + P Y T + + VC ++P +++ Y Sbjct: 148 KVVICVIWVLALLLAFPQGYYS----------TTETMPSRVVCKIEWPEHPNKIYEKVYH 197 Query: 213 TLLLVLQYFGPLCFIFICYFKIYIRLKRRN--------NMMDKMRDNKYRSSETK 259 + VL YF PL I Y + I L+ + + RD + +S +K Sbjct: 198 ICVTVLIYFLPLLVIGYLYTVVGITLRASGIDCSFWNESYLTGSRDERKKSLLSK 252 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/112 (30%), Positives = 50/112 (44%), Gaps = 1/112 (0%) Query: 239 KRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNH 298 K R N + + S +++ M++ +V FA+CWLP IF + N + Sbjct: 409 KFRENCKKRAMSFSEQVSAARKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFI 468 Query: 299 NLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETI 350 ++L AM ST NPI Y LN F+ + F C F S DYE + Sbjct: 469 QQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFIS-AGDYEGL 519 >6DO1-A nrPDB Length = 425 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 106/213 (49%), Gaps = 17/213 (7%) Query: 39 MIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTF 98 MI TL Y + ++G+ GN ++I+I +++ V ++ ++NL+ +DL ++ LP Sbjct: 37 MIPTL---YSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCF-LLTLPLWA 92 Query: 99 VYTLMDH-WVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRH--A 155 VYT M++ W FG +CK+ ++ S+F L ++++R+ I++P R A Sbjct: 93 VYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVA 152 Query: 156 YVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLL 215 V +IW+LA +SLP +I++ + N+T VC + S + L L Sbjct: 153 KVTCIIIWLLAGLASLPAIIHRNVFFIENTNIT--------VCAFHYESQNSTLPIGLGL 204 Query: 216 L--VLQYFGPLCFIFICYFKIYIRLKRRNNMMD 246 +L + P I Y I+ LK+ ++ D Sbjct: 205 TKNILGFLFPFLIILTSYTLIWKALKKAYDLED 237 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 14/91 (15%) Query: 247 KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQ--IIATC------NH 298 +++ NK R+ + +I +++IV+ F W+P IF T D Q II C + Sbjct: 333 EIQKNKPRNDDIFKI---IMAIVLFFFFSWIPHQIF-TFLDVLIQLGIIRDCRIADIVDT 388 Query: 299 NLLFLLCHLTAMISTCVNPIFYGFLNKNFQR 329 + +C A + C+NP+FYGFL K F+R Sbjct: 389 AMPITIC--IAYFNNCLNPLFYGFLGKKFKR 417 >4MQS-A nrPDB Length = 351 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/302 (19%), Positives = 137/302 (45%), Gaps = 27/302 (8%) Query: 43 LALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTL 102 + L G++ ++ + GN+ +++ I + ++ V N + +L+ +DL++ + + +YT+ Sbjct: 43 IVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTV 102 Query: 103 MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW--RPNNRHAYVGIA 160 + +W G +C L + V S+ +L++I+ +R+ + P + + + A + IA Sbjct: 103 IGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 162 Query: 161 VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQY 220 WVL+ P +++ +Q + + C+ QF S++ + T + + Sbjct: 163 AAWVLSFILWAPAILF-------WQFIVGVRTVEDGECYIQFFSNA---AVTFGTAIAAF 212 Query: 221 FGPLCFIFICYFKIYIRLKRRNNMMDKMRD----------NKYRSSETKRINIMLLSIVV 270 + P+ + + Y+ I R + DK K S K++ +L+I++ Sbjct: 213 YLPVIIMTVLYWHIS-RASKSRIKKDKKEPVANQDPVSTRKKPPPSREKKVTRTILAILL 271 Query: 271 AFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRD 330 AF + W P + + + A C N ++ + + I++ +NP Y N F++ Sbjct: 272 AFIITWAPYNVMVLI----NTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKT 327 Query: 331 LQ 332 + Sbjct: 328 FK 329 >5UIW-A nrPDB Length = 411 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 80/387 (20%), Positives = 158/387 (40%), Gaps = 82/387 (21%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHW 106 Y V I G GN+ +I+I++ K ++++T+I ++NL+ SDL ++ +PF + + W Sbjct: 39 YSLVFIFGFVGNMLVILILINYKRLKSMTDIYLLNLAISDLFF-LLTVPF-WAHYAAAQW 96 Query: 107 VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGI---AVIW 163 FG MC+L + + IF ++L+ ++R+ +++ + R G+ + W Sbjct: 97 DFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAV-FALKARTVTFGVVTSVITW 155 Query: 164 VLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRL--SYTTL-LLVLQY 220 V+AV +SLP +I+ E Y C FP ++ ++ TL +++L Sbjct: 156 VVAVFASLPNIIFTRSQKEGLH----------YTCSSHFPYSQYQFWKNFQTLKIVILGL 205 Query: 221 FGPLCFIFICY---FKIYIRLKR------------------------------------- 240 PL + ICY K +R+K+ Sbjct: 206 VLPLLVMVICYSGILKTLLRMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVCP 265 Query: 241 ----RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLP------LTIFNTVFDWNH 290 + +++ + K R + + ++ +I++ + + W P L F F N+ Sbjct: 266 LCGVGKDQFEEVEEEKKRHRDVR----LIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNN 321 Query: 291 QIIATCNH-NLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFN------FCDFRSR 343 ++ N + + M C+NPI Y F+ + F+ L FF C + Sbjct: 322 --CSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEEFRNYLLVFFQKHIFCKCCSIFQQ 379 Query: 344 DDDYETIAMSTMHTDVSKTSLKQASPV 370 + ++ T T + S+ P+ Sbjct: 380 EAPERASSVYTRSTGEQEISVGLGRPL 406 >6AKX-A nrPDB Length = 381 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 75/347 (21%), Positives = 146/347 (42%), Gaps = 76/347 (21%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHW 106 Y V I G GN+ +I+I++ K ++++T+I ++NL+ SDL ++ +PF + + W Sbjct: 39 YSLVFIFGFVGNMLVILILINYKRLKSMTDIYLLNLAISDLFF-LLTVPF-WAHYAAAQW 96 Query: 107 VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGI---AVIW 163 FG MC+L + + IF ++L+ ++R+ +++ + R G+ + W Sbjct: 97 DFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAV-FALKARTVTFGVVTSVITW 155 Query: 164 VLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRL--SYTTL-LLVLQY 220 V+AV +SLP +I+ E Y C FP ++ ++ TL +++L Sbjct: 156 VVAVFASLPNIIFTRSQKEGLH----------YTCSSHFPYSQYQFWKNFQTLKIVILGL 205 Query: 221 FGPLCFIFICY---FKIYIRLKR------------------------------------- 240 PL + ICY K +R+K+ Sbjct: 206 VLPLLVMVICYSGILKTLLRMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVCP 265 Query: 241 ----RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLP------LTIFNTVFDWNH 290 + +++ + K R + + ++ +I++ + + W P L F F N+ Sbjct: 266 LCGVGKDQFEEVEEEKKRHRDVR----LIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNN 321 Query: 291 QIIATCNH-NLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFN 336 ++ N + + M C+NPI Y F+ + F+ L FF Sbjct: 322 --CSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEEFRNYLLVFFQ 366 >6A94-A nrPDB Length = 376 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 102/212 (48%), Gaps = 22/212 (10%) Query: 44 ALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLM 103 AL VIIL ++GN+ +I+ + +K+++N TN +++L+ +D+L+ + +P + + L Sbjct: 12 ALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILY 71 Query: 104 DH-WVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP-RGWRPNNR-HAYVGIA 160 + W +C + ++ + T I+ L I+++R+ I NP R N+R A++ I Sbjct: 72 GYRWPLPSKLCAVWIYLDVLFSTAKIWHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKII 131 Query: 161 VIWVLAVASSLPFLIYQVMTDEP-FQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQ 219 +W ++V S+P ++ + D F+ + D +V F S Sbjct: 132 AVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVS--------------- 176 Query: 220 YFGPLCFIFICYFKIYIRLKRRNNMMDKMRDN 251 +F PL + I YF + +K + DN Sbjct: 177 FFIPLTIMVITYF---LTIKSLQKEAADLEDN 205 >5LWE-A nrPDB Length = 331 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 72/297 (24%), Positives = 134/297 (45%), Gaps = 35/297 (11%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHW 106 Y V I+G GN +I++ + T++ ++NL+ +DLL ++ LPF + D W Sbjct: 33 YWLVFIVGALGNSLVILVYWYCARAKTATDMFLLNLAIADLLF-LVTLPF-WAIAAADQW 90 Query: 107 VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLI---INPRGWRPNNRHAYVGIA--V 161 F MCK+ + ++ + ++ I V+R+ I + WR R Y + Sbjct: 91 KFQTFMCKVVNSMYKMNFYSCVLLIMCICVDRYIAIAQAMRAHTWR-EKRLLYSKMVCFT 149 Query: 162 IWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSD-SHRLSYTTLLL--VL 218 IWVLA A +P ++Y + +E +C +PSD S +L L L +L Sbjct: 150 IWVLAAALCIPEILYSQIKEE----------SGIAICTMVYPSDESTKLKSAVLALKVIL 199 Query: 219 QYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLP 278 +F P + CY I + ++ + +K+++ + I +L++ V + Sbjct: 200 GFFLPFVVMACCYTIII------HTLIQAKKSSKHKALKA---TITVLTVFVLSQFPYNC 250 Query: 279 LTIFNTVFDWNHQIIATCNH----NLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDL 331 + + T+ D I+ C ++ F + A +C+NP+ Y F+ + F+RDL Sbjct: 251 ILLVQTI-DAYAMFISNCAVSTAIDICFQVTQAIAFFHSCLNPVLYVFVGERFRRDL 306 >6CM4-A nrPDB Length = 430 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 49/200 (24%), Positives = 92/200 (46%), Gaps = 24/200 (12%) Query: 55 VSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCK 114 V GN+ + + + ++K ++ TN LIV+L+ +DLLVA + +P+ ++ W F C Sbjct: 15 VFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCD 74 Query: 115 LNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWR---PNNRHAYVGIAVIWVLAVASSL 171 + + + T S +L I+++R+ + P + + R V I+++WVL+ S Sbjct: 75 IFVTLDVMMCTASALNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISC 134 Query: 172 PFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICY 231 P L N D+ C P ++ ++ ++ P + Y Sbjct: 135 PLLF-------GLNNA------DQNECIIANP------AFVVYSSIVSFYVPFIVTLLVY 175 Query: 232 FKIYIRLKRR--NNMMDKMR 249 KIYI L+RR N+ + +R Sbjct: 176 IKIYIVLRRRRKRNIFEMLR 195 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 38/84 (45%), Gaps = 12/84 (14%) Query: 251 NKYRSSETKRINIMLLSIVVA--FAVCWLPLTIFNTVFDWNHQIIATCNHNL---LFLLC 305 + Y+ S+ K ++ +VA F +CWLP I H + C+ N+ L+ Sbjct: 346 DAYKLSQQKEKKATQMAAIVAGVFIICWLPFFI-------THILNIHCDCNIPPVLYSAF 398 Query: 306 HLTAMISTCVNPIFYGFLNKNFQR 329 +++ VNPI Y N F++ Sbjct: 399 TWLGYVNSAVNPIIYTTFNIEFRK 422 >4XT3-A nrPDB Length = 362 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 76/307 (24%), Positives = 134/307 (43%), Gaps = 44/307 (14%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHW 106 YG V + G GN +I I ++ ++ ++ +NL+ +DLL + LP Y L+DH Sbjct: 48 YGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLF-VCTLPLWMQY-LLDHN 105 Query: 107 VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLA 166 C L V++ S+ + IA++R+ I+ R +RP + I W+ A Sbjct: 106 SLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMR-YRPVKQACLFSI-FWWIFA 163 Query: 167 VASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFG---- 222 V ++P + V+T + Q +T D +SY +L V G Sbjct: 164 VIIAIPH--FMVVTKKDNQCMT--------------DYDYLEVSYPIILNVELMLGAFVI 207 Query: 223 PLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLP--LT 280 PL I CY++I + + + ++++ RI +L+++V+ F + WLP LT Sbjct: 208 PLSVISYCYYRI--------SRIVAVSQSRHKG----RIVRVLIAVVLVFIIFWLPYHLT 255 Query: 281 IFNTVFDWNHQIIATCNHN----LLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFN 336 +F I ++C +L A C+NP+ Y F+ F+++L Sbjct: 256 LFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLA 315 Query: 337 FCDFRSR 343 +FR R Sbjct: 316 --EFRQR 320 >6DRY-A nrPDB Length = 411 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 51/202 (25%), Positives = 102/202 (50%), Gaps = 17/202 (8%) Query: 50 VIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDH-WVF 108 VII + GN +I+ + +K+++ TN +++L+ +DLLV + +P + + + W Sbjct: 29 VIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPL 88 Query: 109 GEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP-RGWRPNNRH-AYVGIAVIWVLA 166 +C F+ + T SI+ L I+V+R+ I P + + N+R A++ I V+W+++ Sbjct: 89 PLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLIS 148 Query: 167 VASSLPFLIYQVMTD-EPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLC 225 + ++P I + TD + N+T K+++ F F S + +F PL Sbjct: 149 IGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGS------------LAAFFTPLA 196 Query: 226 FIFICYF-KIYIRLKRRNNMMD 246 + + YF I+ K+ ++ D Sbjct: 197 IMIVTYFLTIHALQKKAADLED 218 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 24/90 (26%), Positives = 40/90 (44%), Gaps = 8/90 (8%) Query: 256 SETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHL---TAMIS 312 S +R + +L + F + W P I N + +CN L +L + +S Sbjct: 324 SNEQRASKVLGIVFFLFLLMWCPFFITNITL----VLCDSCNQTTLQMLLEIFVWIGYVS 379 Query: 313 TCVNPIFYGFLNKNFQRDLQFFFNFCDFRS 342 + VNP+ Y NK F RD + C++R+ Sbjct: 380 SGVNPLVYTLFNKTF-RDAFGRYITCNYRA 408 >5WB1-A nrPDB Length = 458 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 73/296 (24%), Positives = 130/296 (43%), Gaps = 42/296 (14%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHW 106 YG V + G GN +I I ++ ++ ++ +NL+ +DLL + LP Y L+DH Sbjct: 48 YGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLF-VCTLPLWMQY-LLDHN 105 Query: 107 VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLA 166 C L V++ S+ + IA++R+ I+ R +RP + I W+ A Sbjct: 106 SLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMR-YRPVKQACLFSI-FWWIFA 163 Query: 167 VASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFG---- 222 V ++P + V+T + Q +T D +SY +L V G Sbjct: 164 VIIAIPH--FMVVTKKDNQCMT--------------DYDYLEVSYPIILNVELMLGAFVI 207 Query: 223 PLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLP--LT 280 PL I CY++I + + + ++++ RI +L+++V+ F + WLP LT Sbjct: 208 PLSVISYCYYRI--------SRIVAVSQSRHKG----RIVRVLIAVVLVFIIFWLPYHLT 255 Query: 281 IFNTVFDWNHQIIATCNHN----LLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQ 332 +F I ++C +L A C+NP+ Y F+ F+++L Sbjct: 256 LFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELH 311 >5XJM-A nrPDB Length = 422 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 95/205 (46%), Gaps = 12/205 (5%) Query: 42 TLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYT 101 + + Y + ++G N+ ++ + QK + V++I I NL+ +DLL+ + Y+ Sbjct: 13 AIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYS 72 Query: 102 LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP-RGWRPNNRHAYVGIA 160 W+FG MCK+ +++ SIF + ++V+R+Q +I P R N A + Sbjct: 73 YRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVP 132 Query: 161 VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLL---V 217 ++W +A SSLP F++V Y C FP + + + L + Sbjct: 133 LVWCMACLSSLPTFY--------FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNI 184 Query: 218 LQYFGPLCFIFICYFKIYIRLKRRN 242 L + PL FI CYF I L + N Sbjct: 185 LGFIIPLIFIATCYFGIRKHLLKTN 209 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 12/103 (11%) Query: 241 RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTI--FNTVFDW-----NHQII 293 RN + K N+ + + M ++V+AF +CWLP + F W + ++I Sbjct: 307 RNAYIQKYLKNRITRDQVLK---MAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVI 363 Query: 294 ATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFN 336 A + L F + L ++CVNP Y F+ FQ+ L+ F Sbjct: 364 AVIDLALPFAI--LLGFTNSCVNPFLYCFVGNRFQQKLRSVFR 404 >4XNV-A nrPDB Length = 421 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 82/345 (23%), Positives = 137/345 (39%), Gaps = 64/345 (18%) Query: 41 FTLALAYGAVIILGVSGN-LALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFV 99 + L Y V I+G GN +A+ + + K ++ + + NL+ +D L + F Sbjct: 51 YYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGIS-VYMFNLALADFLYVLTLPALIFY 109 Query: 100 YTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRG--WRPNNRHAYV 157 Y W+FG+AMCKL F+ V++ SI L I+ R+ ++ P R ++A Sbjct: 110 YFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAIC 169 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLS---YTTL 214 ++W++ V + P L Y + +T C+D SD + S Y+ Sbjct: 170 ISVLVWLIVVVAISPILFYSGTGVRKNKTIT---------CYDT-TSDEYLRSYFIYSMC 219 Query: 215 LLVLQYFGPLCFIFICYFKIY----IRLKRRN--------NMMDKMRDN----------- 251 V + PL I CY I ++K+ N D DN Sbjct: 220 TTVAMFCVPLVLILGCYGLIVRALIYKMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDI 279 Query: 252 --------------KYRSSET--KRINIMLLSIVVA-FAVCWLPLTIFNTV---FDWNHQ 291 ++ E +R +I L+ IV+ FAV ++P + T+ + Q Sbjct: 280 PDDWVCPLCGVGKDQFEEVEEPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQ 339 Query: 292 IIATCNHN----LLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQ 332 A C N + + A +++CVNPI Y F+R L Sbjct: 340 TPAMCAFNDRVYATYQVTRGLASLNSCVNPILYFLAGDTFRRRLS 384 >2LNL-A nrPDB Length = 309 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 74/304 (24%), Positives = 143/304 (47%), Gaps = 42/304 (13%) Query: 41 FTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVY 100 + + +AY V +L + GN ++++IL + R+VT++ ++NL+ +DLL A+ LP + Sbjct: 21 YVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALT-LPI-WAA 78 Query: 101 TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIA 160 + ++ W+FG +CK+ ++ V+ I L I+V+R+ I++ RH + Sbjct: 79 SKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVC 138 Query: 161 V-IWVLAVASSLPFLIYQVMTDEPFQNVTLDAYK---DKYVCFDQFPSDSHRLSYTTLLL 216 + W L++ SLPF +++ AY VC++ +D+ + + +L Sbjct: 139 LGCWGLSMNLSLPFFLFR------------QAYHPNNSSPVCYEVLGNDTAK--WRMVLR 184 Query: 217 VLQY-FG---PLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAF 272 +L + FG PL + CY +R + +M K R + ++ ++V+ F Sbjct: 185 ILPHTFGFIVPLFVMLFCY-GFTLRTLFKAHMGQKHRAMR-----------VIFAVVLIF 232 Query: 273 AVCWLP--LTIFNTVFDWNHQIIATC----NHNLLFLLCHLTAMISTCVNPIFYGFLNKN 326 +CWLP L + I +C N + + +C+NPI Y F+ +N Sbjct: 233 LLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQN 292 Query: 327 FQRD 330 F+ Sbjct: 293 FRHG 296 >4U15-A nrPDB Length = 418 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 44/202 (21%), Positives = 98/202 (48%), Gaps = 12/202 (5%) Query: 43 LALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTL 102 +A G + ++ + GN+ +I+ K+++ V N +++L+ +DL++ ++ + Y + Sbjct: 15 IAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYII 74 Query: 103 MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPN--NRHAYVGIA 160 M+ W G C L + V+ S+ +L++I+ +R+ I P +R + A V I Sbjct: 75 MNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIG 134 Query: 161 VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQY 220 + WV++ P +++ +Q CF QF S+ +++ T + + Sbjct: 135 LAWVISFVLWAPAILF-------WQYFVGKRTVPPGECFIQFLSEPT-ITFGT--AIAAF 184 Query: 221 FGPLCFIFICYFKIYIRLKRRN 242 + P+ + I Y++IY ++ N Sbjct: 185 YMPVTIMTILYWRIYKETEKMN 206 Score = 34.3 bits (77), Expect = 0.097, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 4/72 (5%) Query: 257 ETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVN 316 + K+ L +I++AF + W P I V + I NL + LC+ I++ VN Sbjct: 325 KEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCY----INSTVN 380 Query: 317 PIFYGFLNKNFQ 328 P+ Y NK F+ Sbjct: 381 PVCYALCNKTFR 392 >4U14-A nrPDB Length = 460 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 44/202 (21%), Positives = 98/202 (48%), Gaps = 12/202 (5%) Query: 43 LALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTL 102 +A G + ++ + GN+ +I+ K+++ V N +++L+ +DL++ ++ + Y + Sbjct: 15 IAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYII 74 Query: 103 MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPN--NRHAYVGIA 160 M+ W G C L + V+ S+ +L++I+ +R+ I P +R + A V I Sbjct: 75 MNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIG 134 Query: 161 VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQY 220 + WV++ P +++ +Q CF QF S+ +++ T + + Sbjct: 135 LAWVISFVLWAPAILF-------WQYFVGKRTVPPGECFIQFLSEPT-ITFGT--AIAAF 184 Query: 221 FGPLCFIFICYFKIYIRLKRRN 242 + P+ + I Y++IY ++ N Sbjct: 185 YMPVTIMTILYWRIYKETEKMN 206 Score = 34.7 bits (78), Expect = 0.078, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 4/72 (5%) Query: 257 ETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVN 316 + K+ L +I++AF + W P I V + I NL + LC+ I++ VN Sbjct: 368 KEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCY----INSTVN 423 Query: 317 PIFYGFLNKNFQ 328 P+ Y NK F+ Sbjct: 424 PVCYALCNKTFR 435 >5CXV-A nrPDB Length = 515 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 52/223 (23%), Positives = 105/223 (47%), Gaps = 19/223 (8%) Query: 43 LALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTL 102 + + G + + V+GNL ++I E++ V N +++L+ +DL++ + Y L Sbjct: 53 IGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLL 112 Query: 103 MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNN--RHAYVGIA 160 M HW G C L + V+ S+ +L+LI+ +R+ + P +R R A + I Sbjct: 113 MGHWALGTLACDLWLALDYVASQASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIG 172 Query: 161 VIWVLAVASSLP-FLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQ 219 + W+++ P L +Q + E T+ A + C+ QF S +++ T + Sbjct: 173 LAWLVSFVLWAPAILFWQYLVGER----TVLAGQ----CYIQFLSQPI-ITFGTAMAA-- 221 Query: 220 YFGPLCFIFICYFKIYIRLKRRN-----NMMDKMRDNKYRSSE 257 ++ P+ + Y++IY + RN + + +R Y+ +E Sbjct: 222 FYLPVTVMCTLYWRIYRETENRNIFEMLRIDEGLRLKIYKDTE 264 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 22/87 (25%), Positives = 38/87 (43%), Gaps = 5/87 (5%) Query: 257 ETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVN 316 + K+ L +I++AF + W P I V + + L + LC+ +++ +N Sbjct: 408 KEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCY----VNSTIN 463 Query: 317 PIFYGFLNKNFQRDLQFFFNFCDFRSR 343 P+ Y NK F RD C + R Sbjct: 464 PMCYALCNKAF-RDTFRLLLLCRWDKR 489 >3OE9-A nrPDB Length = 499 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 107/212 (50%), Gaps = 22/212 (10%) Query: 43 LALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTL 102 L Y + + G+ GN +I+++ QK++R++T+ ++LS +DLL ++ LPF V + Sbjct: 51 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAV 109 Query: 103 MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP-RGWRPN----NRHAYV 157 + W FG +CK + V++ S++ L I+++R+ I++ RP + YV Sbjct: 110 AN-WYFGNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIVHATNSQRPRKLLAEKVVYV 168 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLV 217 G +W+ A+ ++P I F NV+ D+Y+C +P+D + + ++ Sbjct: 169 G---VWIPALLLTIPDFI--------FANVS--EADDRYICDRFYPNDLWVVVFQFQHIM 215 Query: 218 LQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + P I CY I +L +N+ + +R Sbjct: 216 VGLILPGIVILSCYCIIISKLS--HNIFEMLR 245 Score = 31.6 bits (70), Expect = 0.59, Method: Compositional matrix adjust. Identities = 29/120 (24%), Positives = 41/120 (34%), Gaps = 40/120 (33%) Query: 237 RLKR-----RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIF--------- 282 R KR R D + ++ + + ++L ++AF CWLP I Sbjct: 382 RAKRVITTFRTGTWDAYSGSGHQKRKALKPTVIL---ILAFFACWLPYYIGISIDSFILL 438 Query: 283 ----------NTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQ 332 NTV W + L F C C+NPI Y FL F+ Q Sbjct: 439 EIIKQGCEFENTVHKW-----ISITEALAFFHC--------CLNPILYAFLGAKFKTSAQ 485 >5DSG-A nrPDB Length = 422 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 47/213 (22%), Positives = 101/213 (47%), Gaps = 13/213 (6%) Query: 39 MIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTF 98 M+F +A G++ ++ V GN+ +++ I ++++ V N + +L+ +DL++ + Sbjct: 13 MVF-IATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYT 71 Query: 99 VYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW--RPNNRHAY 156 VY + +W G +C L + V S+ +L++I+ +R+ + P + R + A Sbjct: 72 VYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAG 131 Query: 157 VGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLL 216 + IA WVL+ P +++ +Q V CF QF S+ + T Sbjct: 132 LMIAAAWVLSFVLWAPAILF-------WQFVVGKRTVPDNQCFIQFLSNP---AVTFGTA 181 Query: 217 VLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + ++ P+ + + Y I + + R N+ + +R Sbjct: 182 IAAFYLPVVIMTVLYIHISLASRSRVNIFEMLR 214 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 16/88 (18%), Positives = 41/88 (46%), Gaps = 5/88 (5%) Query: 255 SSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTC 314 ++ +++ + +I++AF + W P + V + I ++ + LC+ +++ Sbjct: 327 AARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCY----VNST 382 Query: 315 VNPIFYGFLNKNFQRDLQFFFNFCDFRS 342 +NP Y N F++ + C +R+ Sbjct: 383 INPACYALCNATFKKTFRHLL-LCQYRN 409 >6BQH-A nrPDB Length = 452 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 33/125 (26%), Positives = 70/125 (56%), Gaps = 3/125 (2%) Query: 61 LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDH-WVFGEAMCKLNPFV 119 +I+ + +K++ N TN +++L+ +D+LV ++ +P + + L D+ W +C + + Sbjct: 61 VIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISL 120 Query: 120 QCVSITVSIFSLVLIAVERHQLIINP-RGWRPNNR-HAYVGIAVIWVLAVASSLPFLIYQ 177 + T SI L I+++R+ I NP R N+R A + IA++W +++ S+P + Sbjct: 121 DVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIG 180 Query: 178 VMTDE 182 + +E Sbjct: 181 LRDEE 185 >6N4B-R nrPDB Length = 495 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 78/325 (24%), Positives = 146/325 (44%), Gaps = 52/325 (16%) Query: 40 IFTLALAYGAVIILGVSGNLALIIIILKQKEMR-NVTNILIVNLSFSDLLVAIMCLPFTF 98 I L+L G +L NL ++ +IL + +R + I +L+ +DLL +++ F Sbjct: 134 IAVLSLTLGTFTVLE---NLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVI-----F 185 Query: 99 VYTLMDHWVFGEAMCKLNPFV-----QCVSITVSIFSLVLIAVERHQLIINPRGWRP--N 151 VY+ +D VF + N F+ S T S+ SL L A++R+ I P ++ Sbjct: 186 VYSFIDFHVFHRKDSR-NVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVT 244 Query: 152 NRHAYVGIAVIWVLA-VASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP--SDSHR 208 A V ++W +A V + LP L + E Q+V C D FP +++ Sbjct: 245 RPKAVVAFCLMWTIAIVIAVLPLLGWNC---EKLQSV----------CSDIFPHIDETYL 291 Query: 209 LSYTTLLLVLQYFGPLCFIFICY------FKIYIRLKRRNNMMDKMRDNKYRSS--ETKR 260 + + + VL F +++I + ++ R +++ ++ D K + + + R Sbjct: 292 MFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQAR 351 Query: 261 INIMLLSIVVAFAV----CWLPL--TIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTC 314 ++I L +V V CW PL + VF +++I T +F C + ++++ Sbjct: 352 MDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKT-----VFAFCSMLCLLNST 406 Query: 315 VNPIFYGFLNKNFQRDLQFFFNFCD 339 VNPI Y +K+ + + F C+ Sbjct: 407 VNPIIYALRSKDLRHAFRSMFPSCE 431 >3UON-A nrPDB Length = 467 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 42/209 (20%), Positives = 102/209 (48%), Gaps = 12/209 (5%) Query: 43 LALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTL 102 + L G++ ++ + GN+ +++ I + ++ V N + +L+ +DL++ + + +YT+ Sbjct: 26 IVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTV 85 Query: 103 MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW--RPNNRHAYVGIA 160 + +W G +C L + V S+ +L++I+ +R+ + P + + + A + IA Sbjct: 86 IGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 145 Query: 161 VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQY 220 WVL+ P +++ +Q + + C+ QF S++ + T + + Sbjct: 146 AAWVLSFILWAPAILF-------WQFIVGVRTVEDGECYIQFFSNA---AVTFGTAIAAF 195 Query: 221 FGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + P+ + + Y+ I K R N+ + +R Sbjct: 196 YLPVIIMTVLYWHISRASKSRINIFEMLR 224 Score = 34.3 bits (77), Expect = 0.097, Method: Compositional matrix adjust. Identities = 18/87 (20%), Positives = 41/87 (47%), Gaps = 5/87 (5%) Query: 256 SETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCV 315 S K++ +L+I++AF + W P + + + A C N ++ + + I++ + Sbjct: 381 SREKKVTRTILAILLAFIITWAPYNVMVLI----NTFCAPCIPNTVWTIGYWLCYINSTI 436 Query: 316 NPIFYGFLNKNFQRDLQFFFNFCDFRS 342 NP Y N F++ + C +++ Sbjct: 437 NPACYALCNATFKKTFKHLL-MCHYKN 462 >3VW7-A nrPDB Length = 484 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 45/210 (21%), Positives = 92/210 (43%), Gaps = 17/210 (8%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDH- 105 Y V ++ + N+ I++ + + +++ + +++L+ +D+L + LPF Y Sbjct: 27 YTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLF-VSVLPFKISYYFSGSD 85 Query: 106 WVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR---GWRPNNRHAYVGIAVI 162 W FG +C+ ++ SI + +I+++R ++ P WR R ++ +A I Sbjct: 86 WQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLA-I 144 Query: 163 WVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPS---DSHRLSYTTLLLVLQ 219 W LA+A +P L+ + P +T C D + + Y + + Sbjct: 145 WALAIAGVVPLLLKEQTIQVPGLGIT--------TCHDVLSETLLEGYYAYYFSAFSAVF 196 Query: 220 YFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 +F PL +CY I L N+ + +R Sbjct: 197 FFVPLIISTVCYVSIIRCLSSSANIFEMLR 226 >4BWB-A nrPDB Length = 338 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 65/307 (21%), Positives = 140/307 (45%), Gaps = 39/307 (12%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNV---TNILIVNLSFSDLLVAIMCLP---FTFVY 100 Y A+ ++G GN + + ++K ++++ + + +L+ SDLL+ + LP + F++ Sbjct: 26 YLALFVVGTVGNGVTLFTLARKKSLQSLQSRVDYYLGSLALSDLLILLFALPVDLYNFIW 85 Query: 101 TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVG 158 + W FG+A CK F++ + ++V ++VE + I +P + + Sbjct: 86 -VHHPWAFGDAGCKGYYFLREACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKF 144 Query: 159 IAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDA-YKDKYVCFDQFPSDSHRLSYTTLLLV 217 I+ IW+ + ++P L + QN++ D + VC + + TL +V Sbjct: 145 ISAIWLASALLAIPMLFTMGL-----QNLSGDGTHPGGLVC-------TPIVDTATLRVV 192 Query: 218 LQYFGPLCFIF---ICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRIN------IMLLSI 268 +Q + F+F + + +R M+ + + +E R+ ++L ++ Sbjct: 193 IQLNTFMSFLFPMLVASILNTVAARRLTVMVHQAAEQGRVCTEPGRVQALRRGVLVLRAV 252 Query: 269 VVAFAVCWLPLTIFNTVF------DWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGF 322 V+AF VCWLP + +F W + ++ ++L + +S +NPI Y Sbjct: 253 VIAFVVCWLPYHVRRLMFVYISDEQWTTALFDF--YHYFYMLSNALVYVSAAINPILYNL 310 Query: 323 LNKNFQR 329 ++ NF++ Sbjct: 311 VSANFRQ 317 >6D26-A nrPDB Length = 470 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 47/220 (21%), Positives = 101/220 (45%), Gaps = 25/220 (11%) Query: 45 LAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMD 104 L +G +LG+ N +I+ ++ + + V +++L+ SDLL + FT+ + Sbjct: 38 LLHGLASLLGLVEN-GVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGH 96 Query: 105 HWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNR---HAYVGIAV 161 W G CKL+ + +++ S F L I+++R ++ P W N+R A+ V Sbjct: 97 SWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPV-WAQNHRTVAAAHKVCLV 155 Query: 162 IWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCF------DQFPS-----DSHRLS 210 +W LAV +++P+ +++ T+ + +C+ + P +S + + Sbjct: 156 LWALAVLNTVPYFVFR---------DTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQAA 206 Query: 211 YTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRD 250 +L + PL I + + +RL+ R ++ + R+ Sbjct: 207 LAVSKFLLAFLVPLAIIASSHAAVSLRLQHRADLGLQHRN 246 >5WF6-A nrPDB Length = 504 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 50/210 (23%), Positives = 100/210 (47%), Gaps = 18/210 (8%) Query: 49 AVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVF 108 A+ +L + GN+ + + ++NVTN +V+L+ +D+ V ++ +PF T+ + Sbjct: 46 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFC- 102 Query: 109 GEAMCKLNPFVQCVSITV---SIFSLVLIAVERHQLIINP---RGWRPNNRHAYVGIAVI 162 A C F+ C + + +IFSL+ IA++R+ I P G R + IA+ Sbjct: 103 --AACHGCLFIACFVLVLTQSAIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI-IAIC 159 Query: 163 WVLAVASSLPFLIYQVMTDEP--FQNVTLDAYKDKYVC-FDQFPSDSHRLSYTTLLLVLQ 219 WVL+ A L ++ +P +N + + + C F+ ++ + + VL Sbjct: 160 WVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV 219 Query: 220 YFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 PL + Y +I++ +R+ N+ + +R Sbjct: 220 ---PLLLMLGVYLRIFLAARRQLNIFEMLR 246 Score = 36.2 bits (82), Expect = 0.023, Method: Compositional matrix adjust. Identities = 32/103 (31%), Positives = 51/103 (49%), Gaps = 14/103 (13%) Query: 237 RLKRRNNMMDKMRDNKYRSSETKRINIML-LSIVVA-FAVCWLPLTIFN--TVFDWNHQI 292 R KR + YRS+ K ++ L+I+V FA+CWLPL I N T F Sbjct: 383 RAKRVITTFRTGTWDAYRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFF------ 436 Query: 293 IATCNHNLLFLLCHLTAMIS---TCVNPIFYGFLNKNFQRDLQ 332 C+H L+L+ +L ++S + VNP Y + + F++ + Sbjct: 437 CPDCSHAPLWLM-YLAIVLSHTNSVVNPFIYAYRIREFRQTFR 478 >5NJ6-A nrPDB Length = 437 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 38/165 (23%), Positives = 77/165 (46%), Gaps = 11/165 (6%) Query: 43 LALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTL 102 L + Y V ++ + N + + L + + + I + NL+ +DLL +++ P Y + Sbjct: 25 LPIVYTIVFVVALPSNGMALWVFLFRTKKKAPAVIYMANLALADLL-SVIWFPLKIAYHI 83 Query: 103 -MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAV 161 ++W++GEA+C + ++ SI L ++V+R I+NP G + +GI++ Sbjct: 84 HGNNWIYGEALCNVLIGFFYANMYCSILFLTCLSVQRAWEIVNPMGHSRKKANIAIGISL 143 Query: 162 -IWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSD 205 IW+L + ++P + + P +T C D P Sbjct: 144 AIWLLILLVTIPLYVVKQTIFIPALQIT--------TCHDVLPEQ 180 Score = 28.1 bits (61), Expect = 6.8, Method: Compositional matrix adjust. Identities = 20/90 (22%), Positives = 45/90 (50%), Gaps = 6/90 (6%) Query: 241 RNNMMDKMRDNKYRSSETKRINIMLLSIVVA--FAVCWLPLTIFNTVFDWNHQIIATCNH 298 RN + K +N SE KR + L++ VA + +C+ P + V + + + Sbjct: 314 RNAYIQKYLEN----SEKKRKRAIKLAVTVAAMYLICFTPSNLLLVVHYFLIKSQGQSHV 369 Query: 299 NLLFLLCHLTAMISTCVNPIFYGFLNKNFQ 328 L+++ + +++C++P Y F++ +F+ Sbjct: 370 YALYIVALCLSTLNSCIDPFVYYFVSHDFR 399 >5NDD-A nrPDB Length = 619 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 38/164 (23%), Positives = 77/164 (46%), Gaps = 11/164 (6%) Query: 43 LALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTL 102 L + Y V ++ + N + + L + + + I + NL+ +DLL +++ P Y + Sbjct: 207 LPIVYTIVFVVALPSNGMALWVFLFRTKKKAPAVIYMANLALADLL-SVIWFPLKIAYHI 265 Query: 103 -MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAV 161 ++W++GEA+C + ++ SI L ++V+R I+NP G + +GI++ Sbjct: 266 HGNNWIYGEALCNVLIGFFYANMYCSILFLTCLSVQRAWEIVNPMGHSRKKANIAIGISL 325 Query: 162 -IWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPS 204 IW+L + ++P + + P +T C D P Sbjct: 326 AIWLLILLVTIPLYVVKQTIFIPALQIT--------TCHDVLPE 361 Score = 27.7 bits (60), Expect = 7.7, Method: Compositional matrix adjust. Identities = 20/90 (22%), Positives = 45/90 (50%), Gaps = 6/90 (6%) Query: 241 RNNMMDKMRDNKYRSSETKRINIMLLSIVVA--FAVCWLPLTIFNTVFDWNHQIIATCNH 298 RN + K +N SE KR + L++ VA + +C+ P + V + + + Sbjct: 496 RNAYIQKYLEN----SEKKRKRAIKLAVTVAAMYLICFTPSNLLLVVHYFLIKSQGQSHV 551 Query: 299 NLLFLLCHLTAMISTCVNPIFYGFLNKNFQ 328 L+++ + +++C++P Y F++ +F+ Sbjct: 552 YALYIVALCLSTLNSCIDPFVYYFVSHDFR 581 >5ZKB-A nrPDB Length = 421 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 28/136 (20%), Positives = 71/136 (52%), Gaps = 2/136 (1%) Query: 43 LALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTL 102 + L G++ ++ + GN+ +++ I + ++ V N + +L+ +DL++ + + +YT+ Sbjct: 28 IVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTV 87 Query: 103 MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW--RPNNRHAYVGIA 160 + +W G +C L + V + +L++I+ +R+ + P + + + A + IA Sbjct: 88 IGYWPLGPVVCDLWLALDYVVSNARVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 147 Query: 161 VIWVLAVASSLPFLIY 176 WVL+ P +++ Sbjct: 148 AAWVLSFILWAPAILF 163 Score = 34.3 bits (77), Expect = 0.089, Method: Compositional matrix adjust. Identities = 18/87 (20%), Positives = 41/87 (47%), Gaps = 5/87 (5%) Query: 256 SETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCV 315 S K++ +L+I++AF + W P + + + A C N ++ + + I++ + Sbjct: 329 SREKKVTRTILAILLAFIITWAPYNVMVLI----NTFCAPCIPNTVWTIGYWLCYINSTI 384 Query: 316 NPIFYGFLNKNFQRDLQFFFNFCDFRS 342 NP Y N F++ + C +++ Sbjct: 385 NPACYALCNATFKKTFKHLL-MCHYKN 410 >5UVI-A nrPDB Length = 447 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 55/234 (23%), Positives = 109/234 (46%), Gaps = 22/234 (9%) Query: 28 FENDDCHLPLAMIFTLALAYG-AVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSD 86 +++DD P M ++ + A+ +L + GN+ + + ++NVTN +V+L+ +D Sbjct: 18 YKDDDDGAPPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAAD 77 Query: 87 LLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITV---SIFSLVLIAVERHQLII 143 + V ++ +PF T+ + A C F+ C + + SIFSL+ IA++R+ I Sbjct: 78 IAVGVLAIPFAI--TISTGFC---AACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIR 132 Query: 144 NP---RGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEP--FQNVTLDAYKDKYVC 198 P G R + IA+ WVL+ A L ++ +P +N + + + C Sbjct: 133 IPLRYNGLVTGTRAKGI-IAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVAC 191 Query: 199 -FDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDN 251 F+ ++ + + VL PL + Y +I++ +R+ + + DN Sbjct: 192 LFEDVVPMNYMVYFNFFACVLV---PLLLMLGVYLRIFLAARRQ---LADLEDN 239 Score = 35.4 bits (80), Expect = 0.044, Method: Compositional matrix adjust. Identities = 31/100 (31%), Positives = 51/100 (51%), Gaps = 14/100 (14%) Query: 237 RLKRRNNMMDKMRDNKYRSSETKRINIML-LSIVVA-FAVCWLPLTIFN--TVFDWNHQI 292 +LK N + + RS+ K ++ L+I+V FA+CWLPL I N T F Sbjct: 326 QLKTTRNAYIQKYLERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFF------ 379 Query: 293 IATCNHNLLFLLCHLTAMIS---TCVNPIFYGFLNKNFQR 329 C+H L+L+ +L ++S + VNP Y + + F++ Sbjct: 380 CPDCSHAPLWLM-YLAIVLSHTNSVVNPFIYAYRIREFRQ 418 >5X33-A nrPDB Length = 523 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 48/226 (21%), Positives = 99/226 (43%), Gaps = 18/226 (7%) Query: 24 QLLAFENDD------CHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNI 77 +L+ +++DD +PL + L+++ +++G+ GN ++ ILK+ R+VT + Sbjct: 1 ELMDYKDDDDKEFSNTFIPLLAMILLSVS----MVVGLPGNTFVVWSILKRMRKRSVTAL 56 Query: 78 LIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVE 137 + V L ++ PF + W FG A C+L ++ VS+ S+ + ++++ Sbjct: 57 M-VLNLALADLAVLLTAPFFLHFLTWGTWSFGLAGCRLCHYICGVSMYASVLLITAMSLD 115 Query: 138 RHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYV 197 R + +P ++ A W+L FL+ + F+ V + + + Sbjct: 116 RSLAVASPF----LSQKVRTKTAARWLLVGIWGASFLLATPVL--AFRKV-VKLTNETDL 168 Query: 198 CFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNN 243 C +PSD H+ + + P + Y I RL+ R + Sbjct: 169 CLAVYPSDRHKAFHLLFEAFTGFVVPFLIVVASYADISRRLRARGS 214 Score = 29.3 bits (64), Expect = 2.9, Method: Compositional matrix adjust. Identities = 19/73 (26%), Positives = 32/73 (43%), Gaps = 6/73 (8%) Query: 268 IVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFL-----LCHLTAMISTCVNPIFYGF 322 I++AFA WLP + + V + + + T + + L +C A +S+ VNP+ Y Sbjct: 395 IILAFAAFWLPYHVVDLV-EGSRVLAGTLDQSKQQLRNARKVCIALAFLSSSVNPLLYAC 453 Query: 323 LNKNFQRDLQFFF 335 R F Sbjct: 454 AGGGLLRSAGVGF 466 >5ZKQ-A nrPDB Length = 438 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 45/206 (21%), Positives = 88/206 (42%), Gaps = 9/206 (4%) Query: 30 NDDCHLPLAMIFTL-ALAYGAVIILGVSGNLALIIIILKQKEMR--NVTNILIVNLSFSD 86 +D H+ +TL + Y + +LGV N ++ + + + N I +VNL+ +D Sbjct: 6 HDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMAD 65 Query: 87 LLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP- 145 +L I + Y +W+ + +C + + ++ S+ L +I R+Q + P Sbjct: 66 MLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVTRPI 125 Query: 146 RGWRPNNRHAYVGIA-VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPS 204 + + N R + ++ VIWV V ++ FLI P + D + CF+ + Sbjct: 126 KTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGDVTR----CFEHYEK 181 Query: 205 DSHRLSYTTLLLVLQYFGPLCFIFIC 230 S + + +V +F I C Sbjct: 182 GSVPVLIIHIFIVFSFFLVFLIILFC 207 >5ZKP-A nrPDB Length = 466 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 48/207 (23%), Positives = 90/207 (43%), Gaps = 11/207 (5%) Query: 30 NDDCHLPLAMIFTL-ALAYGAVIILGVSGNLALIIIILKQKEMR--NVTNILIVNLSFSD 86 +D H+ +TL + Y + +LGV N ++ + + + N I +VNL+ +D Sbjct: 6 HDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMAD 65 Query: 87 LLVAIMCLPFTFVYTL-MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP 145 +L I LP VY +W+ + +C + + ++ S+ L +I R+Q + P Sbjct: 66 MLFLIT-LPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVTRP 124 Query: 146 -RGWRPNNRHAYVGIA-VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP 203 + + N R + ++ VIWV V ++ FLI P + D + CF+ + Sbjct: 125 IKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGDVTR----CFEHYE 180 Query: 204 SDSHRLSYTTLLLVLQYFGPLCFIFIC 230 S + + +V +F I C Sbjct: 181 KGSVPVLIIHIFIVFSFFLVFLIILFC 207 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 28/102 (27%), Positives = 48/102 (47%), Gaps = 17/102 (16%) Query: 241 RNNMMDKMRDNKYRSSETKRINI-MLLSIVVAFAVCW-------LPLTIFNTVFDWN--H 290 R++++ D + +E KR ++ M +++ F +C+ LP T+ F + H Sbjct: 351 RDDIVGWAHDVRGAIAEVKRRDLWMACTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFH 410 Query: 291 QIIATCNHNLLFLLCHLTAMISTCV-NPIFYGFLNKNFQRDL 331 Q I + L LL + CV NP+ Y FL K F++ L Sbjct: 411 QAINDAHQVTLCLLS------TNCVLNPVIYCFLTKKFRKHL 446 >5N2S-A nrPDB Length = 436 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 64/287 (22%), Positives = 123/287 (42%), Gaps = 17/287 (5%) Query: 50 VIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFG 109 + ++ V GN+ +I + + +R+ T IV+L+ +D+LV + +P + + F Sbjct: 126 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVLVGALVIPLAILINIGPQTYFH 185 Query: 110 EAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWR--PNNRHAYVGIAVIWVLAV 167 + P + + SI +L+ IAV+R+ + P ++ R A V IA W+L+ Sbjct: 186 TCLMVACPVL--ILAQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSF 243 Query: 168 ASSL-PFLIYQVMTDEPFQNVTLDAYKDKYV-C-FDQFPSDSHRLSYTTLLLVLQYFGPL 224 L P + ++ + + + C F++ S + + + + VL + Sbjct: 244 VVGLTPMFGWNNLSAVERAWAAAGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLM 303 Query: 225 CFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFN- 283 I++ F + + + KY E K L I FA+ WLPL I N Sbjct: 304 VLIYLEVFALIRKQLNKKVSASSGDPQKYYGKELKIAKSAAL-IAFLFALSWLPLHILNC 362 Query: 284 -TVFDWNHQIIATCNH-NLLFLLCHLTAMISTCVNPIFYGFLNKNFQ 328 T+F +C+ ++L + A ++ +NPI Y F + F+ Sbjct: 363 ITLF------CPSCHKPSILTYIAIFLAHGNSAMNPIVYAFRIQKFR 403 >4BUO-A nrPDB Length = 335 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 59/303 (19%), Positives = 130/303 (42%), Gaps = 33/303 (10%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMC---LP---FTFVY 100 Y A+ ++G GN + + ++K ++++ + + L L ++ +P + F++ Sbjct: 25 YLALFVVGTVGNSVTLFTLARKKSLQSLQSTVDYYLGSLALSDLLILLLAMPVELYNFIW 84 Query: 101 TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVG 158 + W FG+A C+ F++ + ++V ++VE + I +P + + Sbjct: 85 -VHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKF 143 Query: 159 IAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDA-YKDKYVCFDQFPSDSHRLSYTTLLLV 217 I+ IW+ + ++P L + QN++ D + VC + + TL +V Sbjct: 144 ISAIWLASALLAIPMLFTMGL-----QNLSGDGTHPGGLVC-------TPIVDTATLKVV 191 Query: 218 LQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKY-------RSSETKRINIMLLSIVV 270 +Q + F+F + N + + + R +R ++L ++V+ Sbjct: 192 IQVNTFMSFLFPMLVASILNTVIANKLTVMVHQAAFNMTIEPGRVQALRRGVLVLRAVVI 251 Query: 271 AFAVCWLPLTIFNTVF----DWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKN 326 AF VCWLP + +F D ++ ++L + +S +NPI Y ++ N Sbjct: 252 AFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSAN 311 Query: 327 FQR 329 F++ Sbjct: 312 FRQ 314 >5YWY-A nrPDB Length = 332 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 22/70 (31%), Positives = 37/70 (52%), Gaps = 2/70 (2%) Query: 52 ILGVSGNLALIIIILK-QKEMRNVT-NILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFG 109 I GV GNL I+++ K +KE + T L+ L +DLL ++ P T + W G Sbjct: 29 IFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLLVTDLLGTLLVSPVTIATYMKGQWPGG 88 Query: 110 EAMCKLNPFV 119 + +C+ + F+ Sbjct: 89 QPLCEYSTFI 98 >4XEE-A nrPDB Length = 541 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 62/321 (19%), Positives = 133/321 (41%), Gaps = 51/321 (15%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMC---LP---FTFVY 100 Y A+ ++G GN + + ++K ++++ + + +L L ++ +P + F++ Sbjct: 39 YLALFVVGTVGNSVTLFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIW 98 Query: 101 TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVG 158 + W FG+A C+ F++ + ++ ++VER+ I +P + + Sbjct: 99 -VHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKF 157 Query: 159 IAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDA-YKDKYVCFDQFPSDSHRLSYTTLLLV 217 I+ IW+ + ++P L + QN + D + VC + + T+ +V Sbjct: 158 ISAIWLASALLAIPMLFTMGL-----QNRSADGTHPGGLVC-------TPIVDTATVKVV 205 Query: 218 LQ------YFGPLCFIFICYFKIYIRL-------KRRNNMMDKMRDNKYRSS------ET 258 +Q + P+ I I I +L + + N S E Sbjct: 206 IQVNTFMSFLFPMLVISILNTVIANKLTVMVHQAAEQGRVCTVGTHNGLEHSTFNMTIEP 265 Query: 259 KRIN------IMLLSIVVAFAVCWLPLTIFNTVF----DWNHQIIATCNHNLLFLLCHLT 308 R+ ++L ++V+AF VCWLP + +F D ++ ++L + Sbjct: 266 GRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNAL 325 Query: 309 AMISTCVNPIFYGFLNKNFQR 329 S+ +NPI Y ++ NF++ Sbjct: 326 FYASSAINPILYNLVSANFRQ 346 >3V2Y-A nrPDB Length = 520 Score = 37.0 bits (84), Expect = 0.013, Method: Compositional matrix adjust. Identities = 51/215 (23%), Positives = 91/215 (42%), Gaps = 40/215 (18%) Query: 58 NLALIIIILKQKEMRNVTNILIVNLSFSDLLVAI-----MCLPFTFVYTLMD-HWVFGEA 111 N+ +++ I K K+ I NL+ SDLL + + L Y L W E Sbjct: 81 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREG 140 Query: 112 MCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR---GWRPNNRHAYVGIAVIWVLA-V 167 V+++ S+FSL+ IA+ER+ ++ + G NN ++ I+ WV++ + Sbjct: 141 S-------MFVALSASVFSLLAIAIERYITMLKMKLHNG--SNNFRLFLLISACWVISLI 191 Query: 168 ASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFI 227 LP + + ++ + L Y Y+ F TT+ +L L I Sbjct: 192 LGGLPIMGWNCISALSSCSTVLPLYHKHYILF-----------CTTVFTLL-----LLSI 235 Query: 228 FICYFKIYIRLKRRN-----NMMDKMRDNKYRSSE 257 I Y +IY ++ RN + + +R Y+ +E Sbjct: 236 VILYCRIYSLVRTRNIFEMLRIDEGLRLKIYKDTE 270 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 27/82 (32%), Positives = 41/82 (50%), Gaps = 14/82 (17%) Query: 254 RSSETKRINIMLLSIVV----AFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCH--L 307 RSSE N+ LL V+ F CW PL I + D + + TC ++LF + + Sbjct: 412 RSSE----NVALLKTVIIVLSVFIACWAPLFIL-LLLDVGCK-VKTC--DILFRAEYFLV 463 Query: 308 TAMISTCVNPIFYGFLNKNFQR 329 A++++ NPI Y NK +R Sbjct: 464 LAVLNSGTNPIIYTLTNKEMRR 485 >4GRV-A nrPDB Length = 510 Score = 36.6 bits (83), Expect = 0.018, Method: Compositional matrix adjust. Identities = 19/67 (28%), Positives = 35/67 (52%), Gaps = 4/67 (5%) Query: 267 SIVVAFAVCWLPLTIFNTVF----DWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGF 322 ++V+AF VCWLP + +F D ++ ++L + A S+ +NPI Y Sbjct: 413 AVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALAYASSAINPILYNL 472 Query: 323 LNKNFQR 329 ++ NF++ Sbjct: 473 VSANFRQ 479 Score = 27.7 bits (60), Expect = 8.6, Method: Compositional matrix adjust. Identities = 25/136 (18%), Positives = 64/136 (47%), Gaps = 9/136 (6%) Query: 47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMC---LP---FTFVY 100 Y A+ ++G GN + + ++K ++++ + + +L L ++ +P + F++ Sbjct: 39 YLALFVVGTVGNSVTLFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIW 98 Query: 101 TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVG 158 + W FG+A C+ F++ + ++ ++V R+ I +P + + Sbjct: 99 -VHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVARYLAICHPFKAKTLMSRSRTKKF 157 Query: 159 IAVIWVLAVASSLPFL 174 I+ IW+ + ++P L Sbjct: 158 ISAIWLASALLAIPML 173 >5ZTY-A nrPDB Length = 500 Score = 36.6 bits (83), Expect = 0.019, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 65/121 (53%), Gaps = 5/121 (4%) Query: 58 NLALIIIILKQKEMRNVTNIL-IVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLN 116 N+A++ +IL ++R + L I +L+ +D L +++ +FV + H V +A+ L Sbjct: 50 NVAVLYLILSSHQLRRKPSYLFIGSLALADFLASVV-FACSFVNFHVFHGVDSKAVFLLK 108 Query: 117 PFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVGIAVIWVL-AVASSLPF 173 ++ T S+ SL+L A++R+ + P ++ A V + ++WVL A+ S LP Sbjct: 109 IGSVTMTFTASVGSLLLAAIDRYLCLRYPPSYKALLTRGRALVLLGIMWVLSALVSYLPL 168 Query: 174 L 174 + Sbjct: 169 M 169 >6D9H-R nrPDB Length = 389 Score = 35.0 bits (79), Expect = 0.053, Method: Compositional matrix adjust. Identities = 65/286 (22%), Positives = 122/286 (42%), Gaps = 15/286 (5%) Query: 50 VIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFG 109 + ++ V GN+ +I + + +R+ T IV+L+ +D+ V + +P + + F Sbjct: 74 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFH 133 Query: 110 EAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWR--PNNRHAYVGIAVIWVLAV 167 + P + + SI +L+ IAV+R+ + P ++ R A V IA W+L+ Sbjct: 134 TCLMVACPVL--ILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSF 191 Query: 168 ASSL-PFLIYQVMTDEPFQNVTLDAYKDKYV-C-FDQFPSDSHRLSYTTLLLVLQYFGPL 224 L P + ++ + + + C F++ S + + + + VL + Sbjct: 192 VVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLM 251 Query: 225 CFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFN- 283 I++ F + + + KY E K I L I+ FA+ WLPL I N Sbjct: 252 VLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELK-IAKSLALILFLFALSWLPLHILNC 310 Query: 284 -TVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQ 328 T+F + + + +FL +AM NPI Y F + F+ Sbjct: 311 ITLFCPSCHKPSILTYIAIFLTHGNSAM-----NPIVYAFRIQKFR 351 >5WIV-A nrPDB Length = 422 Score = 34.7 bits (78), Expect = 0.063, Method: Compositional matrix adjust. Identities = 36/133 (27%), Positives = 71/133 (53%), Gaps = 7/133 (5%) Query: 48 GAVIILG--VSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDH 105 G V+++G ++GN + + + ++ ++ TN IV+L+ +DLL+A++ L FVY+ + Sbjct: 44 GGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVL-PLFVYSEVQG 102 Query: 106 --WVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW--RPNNRHAYVGIAV 161 W+ +C + + T SIF+L I+V+R + P + + +R + I Sbjct: 103 GAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGA 162 Query: 162 IWVLAVASSLPFL 174 W+L+ A + P L Sbjct: 163 TWLLSAAVAAPVL 175 >5U09-A nrPDB Length = 508 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 29/105 (27%), Positives = 51/105 (48%), Gaps = 15/105 (14%) Query: 245 MDKMRDN-KYRS---SETKRINIMLLSIVVAFAV----CWLPL--TIFNTVFDWNHQIIA 294 + K R+N K R+ S+ R++I L +V V CW PL + VF +++I Sbjct: 394 LSKFRENCKKRAMSFSDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIK 453 Query: 295 TCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCD 339 T +F C + ++++ VNPI Y +K+ + + F C+ Sbjct: 454 T-----VFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCE 493 >3RZE-A nrPDB Length = 452 Score = 33.1 bits (74), Expect = 0.21, Method: Compositional matrix adjust. Identities = 20/65 (30%), Positives = 33/65 (50%), Gaps = 4/65 (6%) Query: 268 IVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNF 327 I+ AF +CW+P IF V + CN +L L I++ +NP+ Y N+NF Sbjct: 378 IMAAFILCWIPYFIFFMVIAFCKN---CCNEHLHMFTIWL-GYINSTLNPLIYPLCNENF 433 Query: 328 QRDLQ 332 ++ + Sbjct: 434 KKTFK 438 >3O8E-A nrPDB Length = 213 Score = 32.0 bits (71), Expect = 0.41, Method: Compositional matrix adjust. Identities = 17/47 (36%), Positives = 29/47 (61%), Gaps = 1/47 (2%) Query: 17 NFSEKNAQLL-AFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALI 62 N +E N Q++ + E++DC L L ++ T AL V ++GVS N ++ Sbjct: 27 NPTEANCQIMNSSESNDCKLILTLVKTGALVTAFVYVIGVSNNFNML 73 >3F0Y-A nrPDB Length = 208 Score = 32.0 bits (71), Expect = 0.43, Method: Compositional matrix adjust. Identities = 17/47 (36%), Positives = 29/47 (61%), Gaps = 1/47 (2%) Query: 17 NFSEKNAQLL-AFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALI 62 N +E N Q++ + E++DC L L ++ T AL V ++GVS N ++ Sbjct: 22 NPTEANCQMMDSSESNDCKLILTLVKTGALVTAFVYVIGVSNNFNML 68 >6M9T-A nrPDB Length = 537 Score = 31.6 bits (70), Expect = 0.65, Method: Compositional matrix adjust. Identities = 22/86 (25%), Positives = 35/86 (40%), Gaps = 7/86 (8%) Query: 258 TKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL-------LFLLCHLTAM 310 T I L++I+ +VCW PL I +N + C + FL+ A Sbjct: 440 TTETAIQLMAIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLAS 499 Query: 311 ISTCVNPIFYGFLNKNFQRDLQFFFN 336 ++ ++P Y L K R L+ F Sbjct: 500 LNQILDPWVYLLLRKILGRPLEVLFQ 525 >4XCS-A nrPDB Length = 219 Score = 31.2 bits (69), Expect = 0.84, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 33/88 (37%), Gaps = 24/88 (27%) Query: 147 GWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDS 206 G P H G A I A F VM D F++++L YK KYV F Sbjct: 13 GLVPRGSHMSSGNAKIGHPAPN----FKATAVMPDGQFKDISLSDYKGKYVVF------- 61 Query: 207 HRLSYTTLLLVLQYFGPLCFIFICYFKI 234 +F PL F F+C +I Sbjct: 62 -------------FFYPLDFTFVCPTEI 76 >4NTJ-A nrPDB Length = 466 Score = 30.8 bits (68), Expect = 0.94, Method: Compositional matrix adjust. Identities = 19/78 (24%), Positives = 37/78 (47%), Gaps = 5/78 (6%) Query: 259 KRINIMLLSIVVAFAVCWLPLTIFNTVFDWNH--QIIATCNHNLLFLLCHLTAMIST--- 313 K++N+ + I+ F +C++P + + + N LF + T +++ Sbjct: 347 KKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNA 406 Query: 314 CVNPIFYGFLNKNFQRDL 331 C+NP Y FL K+F+ L Sbjct: 407 CLNPFIYFFLCKSFRNSL 424 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 36/141 (25%), Positives = 64/141 (45%), Gaps = 19/141 (13%) Query: 45 LAYGAVIILG-VSGNLALIIIILKQKEMRNVTN--ILIVNLSFSDLLVAIMCLPFTFVYT 101 L Y + +G ++ LA+ I ++R+ +N I + N SDLL+ + TF + Sbjct: 39 LLYTVLFFVGLITNGLAMRIFF----QIRSKSNFIIFLKNTVISDLLMIL-----TFPFK 89 Query: 102 LMDHWVFGEA-----MCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP-RGWRPNN-RH 154 ++ G +C++ + ++ +SI L LI ++R+Q P + P N Sbjct: 90 ILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLG 149 Query: 155 AYVGIAVIWVLAVASSLPFLI 175 A + VIW SLP +I Sbjct: 150 AKILSVVIWAFMFLLSLPNMI 170 >5XRA-A nrPDB Length = 438 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 24/101 (23%), Positives = 47/101 (46%), Gaps = 11/101 (10%) Query: 241 RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAV----CWLPL--TIFNTVFDWNHQIIA 294 R++++ D + + R++I L +V V CW PL + VF +++I Sbjct: 341 RDDIVGWAHDVRGAIPDQARMDIELAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIK 400 Query: 295 TCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFF 335 T +F C + ++++ VNPI Y +K+ + + F Sbjct: 401 T-----VFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMF 436 >6IIU-A nrPDB Length = 484 Score = 30.0 bits (66), Expect = 2.0, Method: Compositional matrix adjust. Identities = 14/37 (37%), Positives = 22/37 (59%), Gaps = 1/37 (2%) Query: 246 DKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIF 282 D+ + + R SE + + L I+V +VCWLPL +F Sbjct: 382 DQFEEVEERDSEVEMM-AQALGIMVVASVCWLPLLVF 417 >6AK3-B nrPDB Length = 418 Score = 29.3 bits (64), Expect = 3.3, Method: Compositional matrix adjust. Identities = 63/284 (22%), Positives = 106/284 (37%), Gaps = 57/284 (20%) Query: 29 ENDDCH-----LPLAMIFTLALAYGAVIILGVSGN-LALIIII--LKQKEMRNVTNIL-- 78 +DC P+ M+ T G GN LA++++ +++E + + L Sbjct: 5 SGEDCGSVSVAFPITMLLT-----------GFVGNALAMLLVSRSYRRRESKRKKSFLLC 53 Query: 79 IVNLSFSDLLVAIMCLPFTFV-YTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLV----- 132 I L+ +DL+ ++ P V Y W + +L F +T+++F L Sbjct: 54 IGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFF---GLTMTVFGLSSLFIA 110 Query: 133 -LIAVERHQLIINPRGWRPNNRHAYVGIAV---IWVLAVA-SSLPFL-IYQVMTDEPFQN 186 +AVER I P W ++ + AV +W+ ++A + LP L + Q P Sbjct: 111 SAMAVERALAIRAPH-WYASHMKTRITRAVLLGVWLASLAFALLPVLGVGQYTVQWPGTW 169 Query: 187 VTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFG--PLCFIFICYFKIYIRLKRRNNM 244 + + Q S SH + G L F C L + Sbjct: 170 CFISTGRG-----GQGTSSSHNWGNLFFASAFAFLGLLALTVTFSC------NLATIKAL 218 Query: 245 MDKMRDNKYRSSE-------TKRINIMLLSIVVAFAVCWLPLTI 281 +D+ R S T I L+ I++ +VCW PL I Sbjct: 219 VDRCRAKATASQSSAQWGRITTETAIQLMGIMLVLSVCWSPLLI 262 >3KFV-A nrPDB Length = 308 Score = 28.9 bits (63), Expect = 4.1, Method: Compositional matrix adjust. Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 12/55 (21%) Query: 180 TDEPFQNVTLD-----AYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFI 229 TD P + + LD A KDK+ D PS RL+Y +QY+ P+ FI Sbjct: 179 TDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIERLNY------VQYY-PIVVFFI 226 >3EXW-A nrPDB Length = 213 Score = 28.9 bits (63), Expect = 4.2, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 28/47 (59%), Gaps = 1/47 (2%) Query: 17 NFSEKNAQLLAF-ENDDCHLPLAMIFTLALAYGAVIILGVSGNLALI 62 N + N Q++A E++DC L L ++ T AL V ++GVS + ++ Sbjct: 27 NPTTANCQIMASSESNDCKLILTLVKTGALVTAFVYVIGVSNDFNML 73 >6EEM-B nrPDB Length = 512 Score = 28.9 bits (63), Expect = 4.4, Method: Compositional matrix adjust. Identities = 17/64 (26%), Positives = 27/64 (42%), Gaps = 5/64 (7%) Query: 223 PLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIF 282 P F +C+ RLK K+ DN Y +T +N+ LL V A ++ + Sbjct: 421 PRTFAMVCF-----RLKPTAIFKQKIVDNDYIEDQTNEVNVKLLESVNASGKIYMTHAVV 475 Query: 283 NTVF 286 V+ Sbjct: 476 GGVY 479 >6Q8C-A nrPDB Length = 877 Score = 27.7 bits (60), Expect = 7.6, Method: Compositional matrix adjust. Identities = 13/29 (44%), Positives = 15/29 (51%) Query: 181 DEPFQNVTLDAYKDKYVCFDQFPSDSHRL 209 D NV+ DA K KY C FP S +L Sbjct: 21 DARISNVSEDASKPKYYCLSMFPYPSGKL 49 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5ZBQ-A nrPDB 424 e-119 3SN6-R nrPDB 286 9e-78 5ZBH-A nrPDB 283 6e-77 4LDO-A nrPDB 281 4e-76 5W0P-A nrPDB 275 2e-74 2KS9-A nrPDB 268 2e-72 6B73-A nrPDB 265 2e-71 5DHG-A nrPDB 262 2e-70 4RWA-A nrPDB 259 2e-69 5DYS-A nrPDB 255 2e-68 6IBL-A nrPDB 252 2e-67 6DDF-R nrPDB 245 3e-65 2R4S-A nrPDB 238 3e-63 4GBR-A nrPDB 235 4e-62 6CMO-R nrPDB 233 7e-62 4MQS-A nrPDB 233 1e-61 2VT4-A nrPDB 233 1e-61 5C1M-A nrPDB 232 2e-61 4ZUD-A nrPDB 228 4e-60 5UIW-A nrPDB 228 4e-60 6ME9-A nrPDB 224 3e-59 6GDG-A nrPDB 223 1e-58 6GPS-A nrPDB 221 4e-58 5UNF-A nrPDB 218 3e-57 6C1Q-B nrPDB 211 5e-55 3PWH-A nrPDB 209 1e-54 5VBL-B nrPDB 208 4e-54 5WS3-A nrPDB 207 8e-54 6GPX-A nrPDB 206 1e-53 6G79-S nrPDB 205 3e-53 3P0G-A nrPDB 202 2e-52 4DJH-A nrPDB 201 4e-52 4XNV-A nrPDB 199 1e-51 5N2S-A nrPDB 199 2e-51 6AKX-A nrPDB 198 4e-51 4EJ4-A nrPDB 197 8e-51 5WB1-A nrPDB 196 2e-50 6MET-B nrPDB 193 8e-50 4DKL-A nrPDB 192 2e-49 4ZJC-A nrPDB 186 2e-47 4XT3-A nrPDB 184 7e-47 5O9H-A nrPDB 181 3e-46 3UON-A nrPDB 181 6e-46 4BWB-A nrPDB 180 7e-46 2LNL-A nrPDB 180 8e-46 5LWE-A nrPDB 180 9e-46 6DO1-A nrPDB 179 2e-45 6J20-A nrPDB 177 6e-45 5DSG-A nrPDB 176 1e-44 4U14-A nrPDB 176 2e-44 4U15-A nrPDB 174 5e-44 5T1A-A nrPDB 174 7e-44 4BUO-A nrPDB 174 7e-44 5NDD-A nrPDB 173 1e-43 4IAR-A nrPDB 173 1e-43 5ZKB-A nrPDB 171 3e-43 5CXV-A nrPDB 171 3e-43 3PBL-A nrPDB 171 5e-43 3AYN-A nrPDB 170 1e-42 5V54-A nrPDB 169 2e-42 3OE9-A nrPDB 167 6e-42 4WW3-A nrPDB 167 9e-42 6HLP-A nrPDB 166 1e-41 5UVI-A nrPDB 166 2e-41 5WF6-A nrPDB 164 5e-41 6N4B-R nrPDB 162 2e-40 5XSZ-A nrPDB 161 5e-40 6CM4-A nrPDB 161 7e-40 5X33-A nrPDB 152 2e-37 5ZKP-A nrPDB 152 3e-37 6DRY-A nrPDB 151 5e-37 6A94-A nrPDB 151 7e-37 5XJM-A nrPDB 150 1e-36 5ZKQ-A nrPDB 149 2e-36 3VW7-A nrPDB 146 1e-35 6BQH-A nrPDB 146 2e-35 5NJ6-A nrPDB 140 9e-34 5GLH-A nrPDB 137 1e-32 5GLI-A nrPDB 134 4e-32 6D26-A nrPDB 132 3e-31 5YWY-A nrPDB 100 7e-22 Sequences not found previously or not previously below threshold: 4XEE-A nrPDB 188 5e-48 6D9H-R nrPDB 174 8e-44 3RZE-A nrPDB 144 4e-35 5UEN-A nrPDB 129 2e-30 4GRV-A nrPDB 125 3e-29 5U09-A nrPDB 108 4e-24 5WIV-A nrPDB 105 4e-23 5XRA-A nrPDB 103 1e-22 4NTJ-A nrPDB 98 4e-21 4PHU-A nrPDB 90 2e-18 6AK3-B nrPDB 87 8e-18 3V2Y-A nrPDB 85 6e-17 5ZTY-A nrPDB 81 6e-16 4Z36-A nrPDB 74 8e-14 6M9T-A nrPDB 69 4e-12 6IIU-A nrPDB 60 2e-09 4N9N-A nrPDB 48 8e-06 5B2G-A nrPDB 46 3e-05 5I14-A nrPDB 46 3e-05 5EUT-A nrPDB 46 3e-05 4WTV-A nrPDB 46 3e-05 4TN3-A nrPDB 46 3e-05 4EPI-A nrPDB 46 3e-05 2O7A-A nrPDB 46 3e-05 210L-A nrPDB 46 3e-05 1T8A-A nrPDB 46 3e-05 192L-A nrPDB 46 3e-05 6FW2-A nrPDB 45 4e-05 6A9E-A nrPDB 45 5e-05 2QB0-B nrPDB 45 6e-05 5EWX-A nrPDB 45 6e-05 5XF1-A nrPDB 45 7e-05 4IAP-A nrPDB 44 1e-04 4YXC-A nrPDB 44 1e-04 4YX7-C nrPDB 44 1e-04 5VBA-A nrPDB 44 1e-04 6AJJ-A nrPDB 44 1e-04 5JEA-K nrPDB 44 1e-04 6D9M-A nrPDB 44 1e-04 4XSJ-A nrPDB 44 1e-04 5V86-A nrPDB 43 2e-04 5YQR-A nrPDB 43 3e-04 4EKQ-A nrPDB 42 3e-04 4HTT-A nrPDB 42 4e-04 5EE7-A nrPDB 41 0.001 5CGD-A nrPDB 41 0.001 5VEW-A nrPDB 40 0.002 2LOT-A nrPDB 40 0.002 4K5Y-A nrPDB 39 0.004 5NX2-A nrPDB 33 0.21 6B3J-R nrPDB 32 0.48 5VAI-R nrPDB 32 0.62 >5ZBQ-A nrPDB Length = 525 Score = 424 bits (1089), Expect = e-119, Method: Composition-based stats. Identities = 356/358 (99%), Positives = 357/358 (99%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL Sbjct: 1 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 60 Query: 62 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC 121 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC Sbjct: 61 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC 120 Query: 122 VSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTD 181 VSITVSI+SLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTD Sbjct: 121 VSITVSIWSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTD 180 Query: 182 EPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR 241 EPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR Sbjct: 181 EPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR 240 Query: 242 NNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLL 301 NNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLL Sbjct: 241 NNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLL 300 Query: 302 FLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDV 359 FLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTD Sbjct: 301 FLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDE 358 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 4/27 (14%), Positives = 10/27 (37%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAF 28 S ++Q N + + + A+ Sbjct: 499 KSRWYNQTPNRAKRVITTFRTGTWDAY 525 >3SN6-R nrPDB Length = 514 Score = 286 bits (732), Expect = 9e-78, Method: Composition-based stats. Identities = 80/385 (20%), Positives = 158/385 (41%), Gaps = 43/385 (11%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 S ++Q N + + + A+ D+ + + + +++ V GN+ + Sbjct: 149 KSRWYNQTPNRAKRVITTFRTGTWDAYAADE-----VWVVGMGIVMSLIVLAIVFGNVLV 203 Query: 62 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC 121 I I K + ++ VTN I +L+ +DL++ + +PF + L W FG C+ + Sbjct: 204 ITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDV 263 Query: 122 VSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVGIAVIWVLAVASSLPFLIYQVM 179 + +T SI +L +IAV+R+ I +P ++ A V I ++W+++ +S FL Q+ Sbjct: 264 LCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTS--FLPIQMH 321 Query: 180 TDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLK 239 ++ Y ++ C D F + +Y ++ ++ PL + Y +++ K Sbjct: 322 WYRATHQEAINCYAEETCC-DFFTNQ----AYAIASSIVSFYVPLVIMVFVYSRVFQEAK 376 Query: 240 RRNNMMDK----------------------MRDNKYRSSETKRINIMLLSIVVAFAVCWL 277 R+ +DK +R + + + L I+ F +CWL Sbjct: 377 RQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWL 436 Query: 278 PLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNF 337 P I N V H I +++L + +++ NP+ Y + +F+ Q Sbjct: 437 PFFIVNIV----HVIQDNLIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELL-- 489 Query: 338 CDFRSRDDDYETIAMSTMHTDVSKT 362 C RS Y S +T Sbjct: 490 CLRRSSLKAYGNGYSSNGNTGEQSG 514 >5ZBH-A nrPDB Length = 527 Score = 283 bits (725), Expect = 6e-77, Method: Composition-based stats. Identities = 241/248 (97%), Positives = 245/248 (98%), Gaps = 1/248 (0%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL Sbjct: 11 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 70 Query: 62 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC 121 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC Sbjct: 71 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC 130 Query: 122 VSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTD 181 VSITVSI+SLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTD Sbjct: 131 VSITVSIWSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTD 190 Query: 182 EPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR 241 EPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR Sbjct: 191 EPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR 250 Query: 242 NNMMDKMR 249 N+ + +R Sbjct: 251 -NIFEMLR 257 Score = 144 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 109/110 (99%), Positives = 109/110 (99%) Query: 250 DNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTA 309 DNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTA Sbjct: 411 DNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTA 470 Query: 310 MISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDV 359 MISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTD Sbjct: 471 MISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDE 520 Score = 41.6 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 7/52 (13%), Positives = 17/52 (32%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIIL 53 S ++Q N + + + A++N I + L+ + Sbjct: 384 KSRWYNQTPNRAKRVITTFRTGTWDAYDNKYRSSETKRINIMLLSIVVAFAV 435 >4LDO-A nrPDB Length = 469 Score = 281 bits (718), Expect = 4e-76, Method: Composition-based stats. Identities = 73/336 (21%), Positives = 150/336 (44%), Gaps = 25/336 (7%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 S ++Q N + + + A+ D+ + + + +++ V GN+ + Sbjct: 149 KSRWYNQTPNRAKRVITTFRTGTWDAYAADE-----VWVVGMGIVMSLIVLAIVFGNVLV 203 Query: 62 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQC 121 I I K + ++ VTN I +L+ +DL++ + +PF + L W FG C+ + Sbjct: 204 ITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDV 263 Query: 122 VSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVGIAVIWVLAVASSLPFLIYQVM 179 + +T SI +L +IAV+R+ I +P ++ A V I ++W+++ +S FL Q+ Sbjct: 264 LCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTS--FLPIQMH 321 Query: 180 TDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLK 239 ++ Y ++ C D F + +Y ++ ++ PL + Y +++ K Sbjct: 322 WYRATHQEAINCYAEETCC-DFFTNQ----AYAIASSIVSFYVPLVIMVFVYSRVFQEAK 376 Query: 240 RRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHN 299 R+ +DK ++++ L I+ F +CWLP I N V H I Sbjct: 377 RQLQKIDKFALKEHKA------LKTLGIIMGTFTLCWLPFFIVNIV----HVIQDNLIRK 426 Query: 300 LLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFF 335 +++L + +++ NP+ Y + +F+ Q Sbjct: 427 EVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELL 461 >5W0P-A nrPDB Length = 906 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 81/394 (20%), Positives = 158/394 (40%), Gaps = 46/394 (11%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAF------------------------ENDDCHLPL 37 S ++Q N + + + A+ E +L Sbjct: 134 KSRWYNQTPNRAKRVITTFRTGTWDAYMCGTEGPNFYVPFSNATGVVRSPFEYPQYYLAE 193 Query: 38 AMIFTLALAYG-AVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPF 96 F++ AY +I+LG N + + ++ K++R N +++NL+ +DL + + Sbjct: 194 PWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTS 253 Query: 97 TFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRG-WRPNNRHA 155 T +L ++VFG C L F + ++++SLV++A+ER+ ++ P +R HA Sbjct: 254 TLYTSLHGYFVFGPTGCNLQGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHA 313 Query: 156 YVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLL 215 +G+A WV+A+A + P L + + + + + S+ + Sbjct: 314 IMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCG------IDYYTLKPEVNNESFVIYM 367 Query: 216 LVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVC 275 V+ + P+ IF CY ++ +K + + K + M++ V+AF +C Sbjct: 368 FVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQ---KAEKEVTRMVIIYVIAFLIC 424 Query: 276 WLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFF 335 W+P + + HQ +C + + A + NP+ Y +NK F+ + Sbjct: 425 WVPYASV-AFYIFTHQ--GSCFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFR-NCMLTT 480 Query: 336 NFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASP 369 C DD + VSKT Q +P Sbjct: 481 ICCGKNPLGDDEAS-------ATVSKTETSQVAP 507 >2KS9-A nrPDB Length = 364 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 102/363 (28%), Positives = 163/363 (44%), Gaps = 23/363 (6%) Query: 11 NHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKE 70 + ++ +N SE N + P I A AY +++ V GN+ ++ IIL K Sbjct: 12 SPNISTNTSEPNQFVQ---------PAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKR 62 Query: 71 MRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFS 130 MR VTN +VNL+F++ +A F Y + + W +G CK + F ++ SI+S Sbjct: 63 MRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYS 122 Query: 131 LVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLD 190 + +A +R+ II+P R + V I VIWVLA+ + P Y T + Sbjct: 123 MTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYS----------TTE 172 Query: 191 AYKDKYVCFDQFPSDSHRLS---YTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDK 247 + VC ++P +++ Y + VL YF PL I Y + I L D Sbjct: 173 TMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDS 232 Query: 248 MRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHL 307 + S +++ M++ +V FA+CWLP IF + N + ++L Sbjct: 233 SDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMW 292 Query: 308 TAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQA 367 AM ST NPI Y LN F+ + F C F S DYE + M + ++ S+ + Sbjct: 293 LAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFIS-AGDYEGLEMKSTRYLQTQGSVYKV 351 Query: 368 SPV 370 S + Sbjct: 352 SRL 354 >6B73-A nrPDB Length = 418 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 77/322 (23%), Positives = 150/322 (46%), Gaps = 24/322 (7%) Query: 19 SEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNIL 78 + +NA + + + A+ + Y V ++G+ GN ++ +I++ +M+ TNI Sbjct: 101 TTRNAYIQKYLG---SISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIY 157 Query: 79 IVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVER 138 I NL+ +D LV +PF LM+ W FG+ +CK+ + ++ SIF+L +++V+R Sbjct: 158 IFNLALADALVT-TTMPFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDR 216 Query: 139 HQLIINP---RGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDK 195 + + +P +R + + I IW+L+ + + ++ + D Sbjct: 217 YIAVCHPVKALDFRTPLKAKIINIC-IWLLSSSVGISAIVLGGT--------KVREDVDV 267 Query: 196 YVCFDQFPSDSHRLS---YTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNK 252 C QFP D + + + + P+ I +CY + +RLK + + ++ Sbjct: 268 IECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKS----VRLLSGSR 323 Query: 253 YRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMIS 312 + +RI ++L +V F VCW P+ IF V +T + + C + Sbjct: 324 EKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSS-YYFCIALGYTN 382 Query: 313 TCVNPIFYGFLNKNFQRDLQFF 334 + +NPI Y FL++NF+R + F Sbjct: 383 SSLNPILYAFLDENFKRCFRDF 404 >5DHG-A nrPDB Length = 424 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 81/324 (25%), Positives = 145/324 (44%), Gaps = 24/324 (7%) Query: 19 SEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNIL 78 + +NA + + LPL + T+ Y AV + G+ GN ++ +IL+ +M+ TNI Sbjct: 106 TTRNAYIQKYLG--AFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIY 163 Query: 79 IVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVER 138 I NL+ +D LV ++ LPF L+ W FG A+CK + ++ S F+L ++V+R Sbjct: 164 IFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDR 222 Query: 139 HQLIINPRGW--RPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKY 196 + I +P + A IW LA +P I E ++ Sbjct: 223 YVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVE----------DEEI 272 Query: 197 VCFDQFPS--DSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYR 254 C + P+ D + + + + P+ I +CY + RL+ + + ++ + Sbjct: 273 ECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRG----VRLLSGSREK 328 Query: 255 SSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTC 314 +RI ++L +V F CW P+ +F Q + +L C +++C Sbjct: 329 DRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAIL-RFCTALGYVNSC 387 Query: 315 VNPIFYGFLNKNFQRDLQFFFNFC 338 +NPI Y FL++NF+ + F C Sbjct: 388 LNPILYAFLDENFKACFRKF--CC 409 >4RWA-A nrPDB Length = 411 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 85/323 (26%), Positives = 144/323 (44%), Gaps = 21/323 (6%) Query: 19 SEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNIL 78 + +NA + + LA+ + Y AV +G+ GN+ ++ I++ +M+ TNI Sbjct: 101 TTRNAYIQKYLGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIY 160 Query: 79 IVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVER 138 I NL+ +D L A LPF LM+ W FGE +CK + ++ SIF+L +++V+R Sbjct: 161 IFNLALADAL-ATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDR 219 Query: 139 HQLIINP---RGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDK 195 + + +P +R + + I IWVLA +P ++ V Sbjct: 220 YIAVCHPVKALDFRTPAKAKLINIC-IWVLASGVGVPIMVMAVTRPR----------DGA 268 Query: 196 YVCFDQFPSDSHRLSYT--TLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKY 253 VC QFPS S + + + P+ I +CY + R + + +K Sbjct: 269 VVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGL----MLLRLRSVRLLSGSKE 324 Query: 254 RSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMIST 313 + +RI M+L +V AF VCW P+ IF V+ LC ++ Sbjct: 325 KDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANS 384 Query: 314 CVNPIFYGFLNKNFQRDLQFFFN 336 +NP+ Y FL++NF+R + Sbjct: 385 SLNPVLYAFLDENFKRCFRQLCR 407 >5DYS-A nrPDB Length = 349 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 85/364 (23%), Positives = 159/364 (43%), Gaps = 23/364 (6%) Query: 9 VENHSVHSNFSEKNAQLLA-FENDDCHLPLAMIFTLALAYG-AVIILGVSGNLALIIIIL 66 E + + FS K + + FE +L F++ AY +I+LG N + + + Sbjct: 5 TEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTV 64 Query: 67 KQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITV 126 + K++R N +++NL+ +DL + +L ++VFG C L F + + Sbjct: 65 QHKKLRTPLNYILLNLAVADLFMVFGGFTTILYTSLHGYFVFGPTGCNLEGFFATLGGEI 124 Query: 127 SIFSLVLIAVERHQLIINPRG-WRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQ 185 +++SLV++A+ER+ ++ P +R HA +G+A WV+A+A + P L+ Sbjct: 125 ALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGM 184 Query: 186 NVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMM 245 + + + +++ S+ + V+ + PL IF CY ++ +K Sbjct: 185 QCSCG------IDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQ 238 Query: 246 DKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLC 305 + + K + M++ +V+AF +CWLP + + HQ +C + + Sbjct: 239 QESATTQ---KAEKEVTRMVIIMVIAFLICWLPYAGV-AFYIFTHQ--GSCFGPIFMTIP 292 Query: 306 HLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLK 365 A S NP+ Y +NK F+ + C DD + T VSKT Sbjct: 293 AFFAKTSAVYNPVIYIMMNKQFR-NCMVTTLCCGKNPLGDDEAS-------TTVSKTETS 344 Query: 366 QASP 369 Q +P Sbjct: 345 QVAP 348 >6IBL-A nrPDB Length = 416 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 74/321 (23%), Positives = 152/321 (47%), Gaps = 21/321 (6%) Query: 23 AQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNL 82 QL F D +L A ++L V++L V+GN+ +I I + ++ +TN+ I +L Sbjct: 97 GQLKEFL--DANLAEAAAKVMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSL 154 Query: 83 SFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLI 142 + +DL+V ++ +PF + W++G +C+L + + +T SI +L +IA++R+ I Sbjct: 155 ACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAI 214 Query: 143 INPRGWRP--NNRHAYVGIAVIWVLAVASS-LPFLIYQVMTDEPFQNVTLDAYKDKYVCF 199 +P ++ A V I +W ++ S LP +++ ++P L Y+D C Sbjct: 215 TSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDP---QALKCYQDPGCCD 271 Query: 200 DQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMD---KMRDNKYRSS 256 +Y ++ ++ PL + Y ++Y K + +D K + ++ + Sbjct: 272 FV-----TNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRKIDRASKRKTSRVMAM 326 Query: 257 ETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVN 316 + + L I+ F +CWLP + N V +N ++ + LF+ + ++ +N Sbjct: 327 KEHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLV----PDWLFVAFNWLGYANSAMN 382 Query: 317 PIFYGFLNKNFQRDLQFFFNF 337 PI Y + +F++ + F Sbjct: 383 PIIYC-RSPDFRKAFKRLLAF 402 >6DDF-R nrPDB Length = 356 Score = 245 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 77/299 (25%), Positives = 136/299 (45%), Gaps = 20/299 (6%) Query: 40 IFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFV 99 T+ Y V ++G+ GN ++ +I++ +M+ TNI I NL+ +D L A LPF V Sbjct: 66 AITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSV 124 Query: 100 YTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWR--PNNRHAYV 157 LM W FG +CK+ + ++ SIF+L ++V+R+ + +P R+A + Sbjct: 125 NYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKI 184 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRL--SYTTLL 215 W+L+ A LP + T + C F + + Sbjct: 185 VNVCNWILSSAIGLPVMFM----------ATTKYRQGSIDCTLTFSHPTWYWENLLKICV 234 Query: 216 LVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVC 275 + + P+ I +CY + +RLK + + +K + +RI M+L +V F VC Sbjct: 235 FIFAFIMPVLIITVCYGLMILRLKS----VRMLSGSKEKDRNLRRITRMVLVVVAVFIVC 290 Query: 276 WLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFF 334 W P+ I+ + I T + + C ++C+NP+ Y FL++NF+R + F Sbjct: 291 WTPIHIYVIIKAL-ITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREF 348 >2R4S-A nrPDB Length = 342 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 76/351 (21%), Positives = 147/351 (41%), Gaps = 38/351 (10%) Query: 36 PLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLP 95 + + + +++ V GN+ +I I K + ++ VTN I +L+ +DL++ + +P Sbjct: 6 DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVP 65 Query: 96 FTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNR 153 F + LM W FG C+ + + +T SI +L +IAV+R+ I +P ++ Sbjct: 66 FGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKN 125 Query: 154 HAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTT 213 A V I ++W+++ +S FL Q+ ++ Y ++ C D F + +Y Sbjct: 126 KARVIILMVWIVSGLTS--FLPIQMHWYRATHQEAINCYANETCC-DFFTNQ----AYAI 178 Query: 214 LLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDK----------------------MRDN 251 ++ ++ PL + Y +++ KR+ +DK +R + Sbjct: 179 ASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRS 238 Query: 252 KYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMI 311 + + L I+ F +CWLP I N V H I +++L + + Sbjct: 239 SKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIV----HVIQDNLIRKEVYILLNWIGYV 294 Query: 312 STCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKT 362 ++ NP+ Y + +F+ Q C RS Y S +T Sbjct: 295 NSGFNPLIYC-RSPDFRIAFQELL--CLRRSSLKAYGNGYSSNGNTGEQSG 342 >4GBR-A nrPDB Length = 309 Score = 235 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 74/329 (22%), Positives = 145/329 (44%), Gaps = 22/329 (6%) Query: 36 PLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLP 95 + + + +++ V GN+ +I I K + ++ VTN I +L+ +DL++ + +P Sbjct: 1 DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVP 60 Query: 96 FTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNR 153 F + L W FG C+ + + +T SI +L +IAV+R+ I +P ++ Sbjct: 61 FGAAHILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKN 120 Query: 154 HAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTT 213 A V I ++W+++ +S FL Q+ ++ Y ++ C D F + +Y Sbjct: 121 KARVIILMVWIVSGLTS--FLPIQMHWYRATHQEAINCYAEETCC-DFFTNQ----AYAI 173 Query: 214 LLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFA 273 ++ ++ PL + Y +++ KR+ +DK ++++ L I+ F Sbjct: 174 ASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKFCLKEHKA------LKTLGIIMGTFT 227 Query: 274 VCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQF 333 +CWLP I N V H I +++L + +++ NP+ Y + +F+ Q Sbjct: 228 LCWLPFFIVNIV----HVIQDNLIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQE 282 Query: 334 FFNFCDFRSRDDDYETIAMSTMHTDVSKT 362 C RS Y S +T Sbjct: 283 LL--CLRRSSLKAYGNGYSSNGNTGEQSG 309 >6CMO-R nrPDB Length = 463 Score = 233 bits (595), Expect = 7e-62, Method: Composition-based stats. Identities = 73/333 (21%), Positives = 146/333 (43%), Gaps = 16/333 (4%) Query: 9 VENHSVHSNFSEKNAQLLA-FENDDCHLPLAMIFTLALAYG-AVIILGVSGNLALIIIIL 66 E + + FS + + FE +L F++ AY +I+LG N + + + Sbjct: 144 TEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTV 203 Query: 67 KQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITV 126 + K++R N +++NL+ +DL + + T +L ++VFG C L F + + Sbjct: 204 QHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLQGFFATLGGEI 263 Query: 127 SIFSLVLIAVERHQLIINPRG-WRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQ 185 +++SLV++A+ER+ ++ P +R HA +G+A WV+A+A + P L Sbjct: 264 ALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGL 323 Query: 186 NVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMM 245 + + + + + S+ + V+ + P+ IF CY ++ +K Sbjct: 324 QCSCG------IDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQ 377 Query: 246 DKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLC 305 + + K + M++ V+AF +CW+P + + HQ +C + + Sbjct: 378 QESATTQ---KAEKEVTRMVIIYVIAFLICWVPYASV-AFYIFTHQ--GSCFGPIFMTIP 431 Query: 306 HLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFC 338 A + NP+ Y +NK F+ + C Sbjct: 432 AFFAKSAAIYNPVIYIMMNKQFR-NCMLTTICC 463 >4MQS-A nrPDB Length = 351 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 59/309 (19%), Positives = 135/309 (43%), Gaps = 25/309 (8%) Query: 40 IFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFV 99 + + L G++ ++ + GN+ +++ I + ++ V N + +L+ +DL++ + + + Sbjct: 40 VVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTL 99 Query: 100 YTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW--RPNNRHAYV 157 YT++ +W G +C L + V S+ +L++I+ +R+ + P + + + A + Sbjct: 100 YTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGM 159 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLV 217 IA WVL+ P +++ Q + + C+ QF S+ + T + Sbjct: 160 MIAAAWVLSFILWAPAILFW-------QFIVGVRTVEDGECYIQFFSN---AAVTFGTAI 209 Query: 218 LQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR---------DNKYRSSETKRINIMLLSI 268 ++ P+ + + Y+ I K R K K S K++ +L+I Sbjct: 210 AAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSTRKKPPPSREKKVTRTILAI 269 Query: 269 VVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQ 328 ++AF + W P + + + A C N ++ + + I++ +NP Y N F+ Sbjct: 270 LLAFIITWAPYNVMVLI----NTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFK 325 Query: 329 RDLQFFFNF 337 + + Sbjct: 326 KTFKHLLMC 334 >2VT4-A nrPDB Length = 313 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 67/307 (21%), Positives = 141/307 (45%), Gaps = 17/307 (5%) Query: 35 LPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCL 94 L ++L V++L V+GN+ +I I + ++ +TN+ I +L+ +DL+V ++ + Sbjct: 6 LSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVV 65 Query: 95 PFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NN 152 PF + W++G +C+L + + +T SI +L +IA++R+ I +P ++ Sbjct: 66 PFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTR 125 Query: 153 RHAYVGIAVIWVLAVASS-LPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSY 211 A V I +W ++ S LP +++ ++P L Y+D C +Y Sbjct: 126 ARAKVIICTVWAISALVSFLPIMMHWWRDEDP---QALKCYQDPGCCDFV-----TNRAY 177 Query: 212 TTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMD-KMRDNKYRSSETKRINIMLLSIVV 270 ++ ++ PL + ++Y K + +D + + + L I+ Sbjct: 178 AIASSIISFYIPLLIMIFVALRVYREAKEQIRKIDRASKRKRVMLMREHKALKTLGIIMG 237 Query: 271 AFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRD 330 F +CWLP + N V +N ++ + LF+ + ++ +NPI Y + +F++ Sbjct: 238 VFTLCWLPFFLVNIVNVFNRDLV----PDWLFVAFNWLGYANSAMNPIIYC-RSPDFRKA 292 Query: 331 LQFFFNF 337 + F Sbjct: 293 FKRLLAF 299 >5C1M-A nrPDB Length = 296 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 76/296 (25%), Positives = 134/296 (45%), Gaps = 20/296 (6%) Query: 40 IFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFV 99 T+ Y V ++G+ GN ++ +I++ +M+ TNI I NL+ +D L A LPF V Sbjct: 17 AITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSV 75 Query: 100 YTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWR--PNNRHAYV 157 LM W FG +CK+ + ++ SIF+L ++V+R+ + +P R+A + Sbjct: 76 NYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKI 135 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRL--SYTTLL 215 W+L+ A LP + T + C F + + Sbjct: 136 VNVCNWILSSAIGLPVMFM----------ATTKYRQGSIDCTLTFSHPTWYWENLLKICV 185 Query: 216 LVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVC 275 + + P+ I +CY + +RLK + + +K + +RI M+L +V F VC Sbjct: 186 FIFAFIMPVLIITVCYGLMILRLKS----VRMLSGSKEKDRNLRRITRMVLVVVAVFIVC 241 Query: 276 WLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDL 331 W P+ I+ + I T + + C ++C+NP+ Y FL++NF+R Sbjct: 242 WTPIHIYVIIKAL-ITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCF 296 >4ZUD-A nrPDB Length = 410 Score = 228 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 80/329 (24%), Positives = 148/329 (44%), Gaps = 32/329 (9%) Query: 19 SEKNAQLLAFE-NDDCHLPLA-----MIFTLALAYGAVIILGVSGNLALIIIILKQKEMR 72 + +NA + + + P A + + Y + ++G+ GN ++I+I +++ Sbjct: 96 TTRNAYIQKYLILNSSDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK 155 Query: 73 NVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLV 132 V ++ ++NL+ +DL + + + W FG +CK+ ++ S+F L Sbjct: 156 TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT 215 Query: 133 LIAVERHQLIINPRGWRPNNRH--AYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLD 190 ++++R+ I++P R A V +IW+LA +SLP +I++ + N+T Sbjct: 216 CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNIT-- 273 Query: 191 AYKDKYVCFDQFPSDSHRLSYTTLLL--VLQYFGPLCFIFICYFKIYIRLKRRNNMMDKM 248 VC + S + L L +L + P I Y I+ LK+ + Sbjct: 274 ------VCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEI---- 323 Query: 249 RDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQ--IIATC----NHNLLF 302 + NK R+ + I ++++IV+ F W+P IF T D Q II C + Sbjct: 324 QKNKPRNDD---IFKIIMAIVLFFFFSWIPHQIF-TFLDVLIQLGIIRDCRIADIVDTAM 379 Query: 303 LLCHLTAMISTCVNPIFYGFLNKNFQRDL 331 + A + C+NP+FYGFL K F+R Sbjct: 380 PITICIAYFNNCLNPLFYGFLGKKFKRYF 408 >5UIW-A nrPDB Length = 411 Score = 228 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 82/387 (21%), Positives = 147/387 (37%), Gaps = 72/387 (18%) Query: 42 TLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYT 101 L Y V I G GN+ +I+I++ K ++++T+I ++NL+ SDL ++ +PF Y Sbjct: 34 LLPPLYSLVFIFGFVGNMLVILILINYKRLKSMTDIYLLNLAISDLFF-LLTVPFWAHYA 92 Query: 102 LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGI-- 159 W FG MC+L + + IF ++L+ ++R+ +++ + R G+ Sbjct: 93 AA-QWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAV-FALKARTVTFGVVT 150 Query: 160 -AVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTL---L 215 + WV+AV +SLP +I+ E Y C FP ++ + Sbjct: 151 SVITWVVAVFASLPNIIFTRSQKEGLH----------YTCSSHFPYSQYQFWKNFQTLKI 200 Query: 216 LVLQYFGPLCFIFICYFKIYIRLKRRN-----------NMMDKMRDNK------------ 252 ++L PL + ICY I L R N D DN Sbjct: 201 VILGLVLPLLVMVICYSGILKTLLRMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPD 260 Query: 253 -----------------YRSSETKRINIMLLSIVVAFAVCWLPLTI------FNTVFDWN 289 + R ++ +I++ + + W P I F F N Sbjct: 261 DWVCPLCGVGKDQFEEVEEEKKRHRDVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLN 320 Query: 290 HQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFN------FCDFRSR 343 + ++ + + M C+NPI Y F+ + F+ L FF C + Sbjct: 321 N-CSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEEFRNYLLVFFQKHIFCKCCSIFQQ 379 Query: 344 DDDYETIAMSTMHTDVSKTSLKQASPV 370 + ++ T T + S+ P+ Sbjct: 380 EAPERASSVYTRSTGEQEISVGLGRPL 406 >6ME9-A nrPDB Length = 460 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 84/359 (23%), Positives = 151/359 (42%), Gaps = 59/359 (16%) Query: 19 SEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNIL 78 + +NA + + D P + L+ + V GNL +I+ +L+ +++RN N+ Sbjct: 96 TTRNAYIQKYLGDGAR-PSWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLF 154 Query: 79 IVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVER 138 +V+L+ ++L+VA P V D W FGE CK + FV +S+ S++++ IA++R Sbjct: 155 LVSLALANLVVAFYPYPLILVAIFYDGWAFGEEHCKASAFVMGLSVIGSVWNITAIAIDR 214 Query: 139 HQLIINPRGWRPNNRH--AYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKY 196 + I + + R + I +IW+L V + LP + +P Y Sbjct: 215 YLYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPR----------IY 264 Query: 197 VCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYI-----RLKRRN--------N 243 C + YT ++V+ + P+ + CY +I++ R+K+ N Sbjct: 265 SCTFI---QTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARMKKYTCTVCGYIYN 321 Query: 244 MMDKMRDNKYRSS------------------------------ETKRINIMLLSIVVAFA 273 D DN R + + + V FA Sbjct: 322 PEDGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQFEEVECLKPSDLRSFLTMFVVFVIFA 381 Query: 274 VCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQ 332 +C+ PL N Q +A LF+ +L A ++C+NPI YG L++NF+R+ + Sbjct: 382 ICFAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNPIVYGLLDQNFRREYK 440 >6GDG-A nrPDB Length = 479 Score = 223 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 77/336 (22%), Positives = 145/336 (43%), Gaps = 27/336 (8%) Query: 23 AQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNL 82 QL F + + A + + A+ +L + GN+ + + ++NVTN +V+L Sbjct: 153 GQLKEFLDANLAEAAAKAVYITVEL-AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSL 211 Query: 83 SFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSI---TVSIFSLVLIAVERH 139 + +D+ V ++ +PF + A C F+ C + SIFSL+ IA++R+ Sbjct: 212 AAADIAVGVLAIPFAITISTGF-----CAACHGCLFIACFVLVLTQSSIFSLLAIAIDRY 266 Query: 140 QLIINPRGWR--PNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEP--FQNVTLDAYKDK 195 I P + A IA+ WVL+ A L ++ +P + + + + Sbjct: 267 IAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKAHSQGCGEGQ 326 Query: 196 YVC-FDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDK--MRDNK 252 C F+ ++ + + VL PL + Y +I++ +R+ M+ + + Sbjct: 327 VACLFEDVVPMNYMVYFNFFACVL---VPLLLMLGVYLRIFLAARRQLKQMESQPLPGER 383 Query: 253 YRSSETKRIN--IMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFL--LCHLT 308 RS+ K ++ L IV FA+CWLPL I N C+H L+L L + Sbjct: 384 ARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCF----TFFCPDCSHAPLWLMYLAIVL 439 Query: 309 AMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRD 344 + ++ VNP Y + + F++ + R ++ Sbjct: 440 SHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQE 475 >6GPS-A nrPDB Length = 429 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 77/345 (22%), Positives = 137/345 (39%), Gaps = 64/345 (18%) Query: 42 TLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYT 101 L Y V I G GN+ +++I++ K+++ +T+I ++NL+ SDLL ++ LP + ++ Sbjct: 43 LLPPLYSLVFIFGFVGNMLVVLILINYKKLKCLTDIYLLNLAISDLLF-LITLPL-WAHS 100 Query: 102 LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGI-- 159 + WVFG AMCKL + + IF ++L+ ++R+ I++ + R G+ Sbjct: 101 AANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAV-FALKARTVTFGVVT 159 Query: 160 -AVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVL 218 + W++AV +S+P +I+ E YVC FP +T + +L Sbjct: 160 SVITWLVAVFASVPNIIFTKCQKE----------DSVYVCGPYFPRG-WNNFHTIMRNIL 208 Query: 219 QYFGPLCFIFICYFKIYIRLKRRN-----------NMMDKMRDNK--------------- 252 PL + ICY I L R N D DN Sbjct: 209 GLVLPLLIMVICYSGILKTLLRMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWV 268 Query: 253 --------------YRSSETKRINIMLLSIVVAFAVCWLPLTI------FNTVFDWNHQI 292 + R ++ +I++ + + W P I F F ++ Sbjct: 269 CPLCGVGKDQFEEVEEEKKRHRDVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSN-C 327 Query: 293 IATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNF 337 +T + + M C+NPI Y F+ + F+ Sbjct: 328 ESTSQLDQATQVTETLGMTHCCINPIIYAFVGEEFRSLFHIALGC 372 >5UNF-A nrPDB Length = 411 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 79/330 (23%), Positives = 140/330 (42%), Gaps = 27/330 (8%) Query: 19 SEKNAQLLAFEND---DCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVT 75 + +NA + + + + + Y + ++G N+ ++ + QK + V+ Sbjct: 96 TTRNAYIQKYLGSGSCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVS 155 Query: 76 NILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIA 135 +I I NL+ +DLL+ + Y+ W+FG MCK+ +++ SIF + ++ Sbjct: 156 SIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMS 215 Query: 136 VERHQLIINPR-GWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKD 194 V+R+Q +I P R N A + ++W +A SSLP + ++V Y Sbjct: 216 VDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYF--------RDVRTIEYLG 267 Query: 195 KYVCFDQFPSDSHRLSYTTLLL---VLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDN 251 C FP + + + L +L + PL FI CYF I L + N+ Sbjct: 268 VNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSY------- 320 Query: 252 KYRSSETKRINIMLLSIVVAFAVCWLPLTI--FNTVFDWNHQIIATC---NHNLLFLLCH 306 ++ M ++V+AF +CWLP + F W I + +L Sbjct: 321 GKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAI 380 Query: 307 LTAMISTCVNPIFYGFLNKNFQRDLQFFFN 336 L ++CVNP Y F+ FQ+ L+ F Sbjct: 381 LLGFTNSCVNPFLYCFVGNRFQQKLRSVFR 410 >6C1Q-B nrPDB Length = 422 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 80/325 (24%), Positives = 145/325 (44%), Gaps = 32/325 (9%) Query: 19 SEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNIL 78 + +NA + + ++ +P + + + V ++GV GN ++ + + R + I Sbjct: 105 TTRNAYIQKYLSNTLRVPDILALVI---FAVVFLVGVLGNALVVW-VTAFEAKRTINAIW 160 Query: 79 IVNLSFSDLLVAIMCLPFTFVYTL-MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVE 137 +NL+ +D L + + LP F + HW FG A C + P + +++ SI L I+ + Sbjct: 161 FLNLAVADFL-SCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISAD 219 Query: 138 RHQLIINPRGWRPNNRH---AYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKD 194 R L+ P W N R A++ AV W LA+ ++P +Y+V+ +E F Sbjct: 220 RFLLVFKPI-WCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYF--------PP 270 Query: 195 KYVCFDQFPSDSHRL-SYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKY 253 K +C + D R + + LVL + PL + ICY I +R R Sbjct: 271 KVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSR------------ 318 Query: 254 RSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIAT-CNHNLLFLLCHLTAMIS 312 R++ + + +++++V +F + WLP + + + T L LC A I+ Sbjct: 319 RATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYIN 378 Query: 313 TCVNPIFYGFLNKNFQRDLQFFFNF 337 C+NPI Y + FQ L+ Sbjct: 379 CCINPIIYVVAGQGFQGRLRKSLPS 403 >3PWH-A nrPDB Length = 329 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 75/324 (23%), Positives = 139/324 (42%), Gaps = 26/324 (8%) Query: 35 LPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCL 94 +P+ A+ +L + GN+ + + ++NVTN +V+L+ +D+LV ++ + Sbjct: 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADILVGVLAI 60 Query: 95 PFTFVYTLMDHWVFGEAMCKLNPFVQCVSI---TVSIFSLVLIAVERHQLIINPRGWR-- 149 PF + A C F+ C + SIFSL+ IA++R+ I P + Sbjct: 61 PFAITISTGF-----CAACHGCLFIACFVLVLAQSSIFSLLAIAIDRYIAIAIPLRYNGL 115 Query: 150 PNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEP--FQNVTLDAYKDKYVC-FDQFPSDS 206 A IA+ WVL+ A L ++ +P +N + + + C F+ + Sbjct: 116 VTGTRAAGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMN 175 Query: 207 HRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDK--MRDNKYRSSETKRIN-- 262 + + + VL PL + Y +I+ +R+ M+ + + RS+ K ++ Sbjct: 176 YMVYFNFFACVL---VPLLLMLGVYLRIFAAARRQLKQMESQPLPGERARSTLQKEVHAA 232 Query: 263 IMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFL--LCHLTAMISTCVNPIFY 320 I FA+CWLPL I N C+H L+L L + A ++ VNP Y Sbjct: 233 KSAAIIAGLFALCWLPLHIINCF----TFFCPDCSHAPLWLMYLAIVLAHTNSVVNPFIY 288 Query: 321 GFLNKNFQRDLQFFFNFCDFRSRD 344 + + F++ + R ++ Sbjct: 289 AYRIREFRQTFRKIIRSHVLRQQE 312 >5VBL-B nrPDB Length = 407 Score = 208 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 68/337 (20%), Positives = 129/337 (38%), Gaps = 44/337 (13%) Query: 42 TLALAYGAVIILGVSGNLALIIIILKQ-KEMRNVTNILIVNLSFSDLLVAIMCLPFTFVY 100 + Y V +LG +GN ++ + + +E R +I I +L+ +DL + + Sbjct: 48 LIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYT 107 Query: 101 TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHA--YVG 158 W FG CKL+ ++ V++ S F L ++ +R+ I+ P V Sbjct: 108 YRDYDWPFGTFFCKLSSYLIFVNMYASAFCLTGLSFDRYLAIVRPVANARLRLRVSGAVA 167 Query: 159 IAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVL 218 AV+WVLA ++P ++ + D N + Y D + + + + Sbjct: 168 TAVLWVLAALLAMPVMVLRTTGDLENTN-KVQCYMDYSMVATVSSEWAWEVGLGVSSTTV 226 Query: 219 QYFGPLCFIFICYFKI--YIRLKRRN--------NMMDKMRDNKYRSS------------ 256 + P + CYF I I +K+ N D DN Sbjct: 227 GFVVPFTIMLTCYFFIAQTIAMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVC 286 Query: 257 --------------ETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLL- 301 E +R+ +++ +VV FA+C +P + T++ + C+ +L Sbjct: 287 PLCGVGKDQFEEVEERRRLLSIIVVLVVTFALCKMPYHLVKTLYMLGSLLHWPCDFDLFL 346 Query: 302 ---FLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFF 335 F C + +++C+NP Y F + F++ Sbjct: 347 MNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSML 383 >5WS3-A nrPDB Length = 560 Score = 207 bits (526), Expect = 8e-54, Method: Composition-based stats. Identities = 65/261 (24%), Positives = 123/261 (47%), Gaps = 3/261 (1%) Query: 7 SQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIIL 66 ++ + + + + L + + P + L Y V ++ + GN+ + + + Sbjct: 29 NETQEP-FLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVW 87 Query: 67 KQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITV 126 K MR VTN IVNLS +D+LV I CLP T V + + W FG+++CK+ P++Q VS++V Sbjct: 88 KNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSV 147 Query: 127 SIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQN 186 S+ +L IA++R I +P ++ + A I +IW+++ +P I + Sbjct: 148 SVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFP-- 205 Query: 187 VTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMD 246 + VC +++ + + Y ++ Y PLC + + Y +I+ +L R + Sbjct: 206 GLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQGIDC 265 Query: 247 KMRDNKYRSSETKRINIMLLS 267 + Y + LLS Sbjct: 266 SFWNESYLTGSRDERKKSLLS 286 Score = 89.0 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 21/90 (23%), Positives = 42/90 (46%), Gaps = 3/90 (3%) Query: 252 KYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLL---FLLCHLT 308 + ++ ML+ +++ FA+C+LP++I N + T + + F H Sbjct: 457 SKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWL 516 Query: 309 AMISTCVNPIFYGFLNKNFQRDLQFFFNFC 338 ++ NPI Y FL+ F+ + + F+ C Sbjct: 517 VYANSAANPIIYNFLSGKFREEFKAAFSCC 546 >6GPX-A nrPDB Length = 349 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 77/343 (22%), Positives = 137/343 (39%), Gaps = 64/343 (18%) Query: 42 TLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYT 101 L Y V I G GN+ +++I++ K+++ +T+I ++NL+ SDLL ++ LP + ++ Sbjct: 16 LLPPLYSLVFIFGFVGNMLVVLILINYKKLKCLTDIYLLNLAISDLLF-LITLPL-WAHS 73 Query: 102 LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGI-- 159 + WVFG AMCKL + + IF ++L+ ++R+ I++ + R G+ Sbjct: 74 AANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAV-FALKARTVTFGVVT 132 Query: 160 -AVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVL 218 + W++AV +S+P +I+ E YVC FP +T + +L Sbjct: 133 SVITWLVAVFASVPNIIFTKCQKE----------DSVYVCGPYFPRG-WNNFHTIMRNIL 181 Query: 219 QYFGPLCFIFICYFKIYIRLKRRN-----------NMMDKMRDNK--------------- 252 PL + ICY I L R N D DN Sbjct: 182 GLVLPLLIMVICYSGILKTLLRMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWV 241 Query: 253 --------------YRSSETKRINIMLLSIVVAFAVCWLPLTI------FNTVFDWNHQI 292 + R ++ +I++ + + W P I F F ++ Sbjct: 242 CPLCGVGKDQFEEVEEEKKRHRDVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSN-C 300 Query: 293 IATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFF 335 +T + + M C+NPI Y F+ + F+ Sbjct: 301 ESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIAL 343 >6G79-S nrPDB Length = 364 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 72/364 (19%), Positives = 134/364 (36%), Gaps = 74/364 (20%) Query: 30 NDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLV 89 D LP ++ + LA + + N +I + + +++ N LI +L+ +DLLV Sbjct: 9 QDSISLPWKVLLVMLLA--LITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLV 66 Query: 90 AIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW- 148 +I+ +P + +YT+ W G+ +C T SI+ L +IA++R+ I + + Sbjct: 67 SILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYS 126 Query: 149 -RPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSH 207 + + A V IA++WV +++ SLP ++ E + C ++ Sbjct: 127 AKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEE----------EVSECVV----NTD 172 Query: 208 RLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSET--------- 258 + YT V ++ P + Y +IY+ + R R K + Sbjct: 173 HILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGST 232 Query: 259 --------------------------------------------KRINIMLLSIVV-AFA 273 +R L I++ AF Sbjct: 233 SSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFI 292 Query: 274 VCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQF 333 VCWLP I + V H +F +++ +NPI Y N++F++ Sbjct: 293 VCWLPFFIISLVMPICKDACW--FHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHK 350 Query: 334 FFNF 337 F Sbjct: 351 LIRF 354 >3P0G-A nrPDB Length = 501 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 51/216 (23%), Positives = 106/216 (49%), Gaps = 9/216 (4%) Query: 36 PLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLP 95 + + + +++ V GN+ +I I K + ++ VTN I +L+ +DL++ + +P Sbjct: 37 DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVP 96 Query: 96 FTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNR 153 F + LM W FG C+ + + +T SI +L +IAV+R+ I +P ++ Sbjct: 97 FGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKN 156 Query: 154 HAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTT 213 A V I ++W+++ +S FL Q+ ++ Y ++ C D F + +Y Sbjct: 157 KARVIILMVWIVSGLTS--FLPIQMHWYRATHQEAINCYAEETCC-DFFTNQ----AYAI 209 Query: 214 LLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 ++ ++ PL + Y +++ KR+ N+ + +R Sbjct: 210 ASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLR 245 Score = 72.1 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 29/133 (21%), Positives = 46/133 (34%), Gaps = 8/133 (6%) Query: 231 YFKIYIRLKRRNNMMD-KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWN 289 Y + R KR D + + L I+ F +CWLP I N V Sbjct: 376 YNQTPNRAKRVITTFRTGTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIV---- 431 Query: 290 HQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYET 349 H I +++L + +++ NP+ Y + +F+ Q C RS Y Sbjct: 432 HVIQDNLIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELL--CLRRSSLKAYGN 488 Query: 350 IAMSTMHTDVSKT 362 S +T Sbjct: 489 GYSSNGNTGEQSG 501 Score = 42.0 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 4/28 (14%), Positives = 11/28 (39%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFE 29 S ++Q N + + + A++ Sbjct: 372 KSRWYNQTPNRAKRVITTFRTGTWDAYK 399 >4DJH-A nrPDB Length = 480 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 57/244 (23%), Positives = 113/244 (46%), Gaps = 25/244 (10%) Query: 16 SNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVT 75 + ++AQL + H+ A+ + Y V ++G+ GN ++ +I++ +M+ T Sbjct: 3 TTMGSEDAQL-----EPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTAT 57 Query: 76 NILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIA 135 NI I NL+ +D LV +PF LM+ W FG+ +CK+ + ++ SIF+L +++ Sbjct: 58 NIYIFNLALADALVT-TTMPFQSTVYLMNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMS 116 Query: 136 VERHQLIINP---RGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAY 192 V+R+ + +P +R + + I IW+L+ + + ++ + Sbjct: 117 VDRYIAVCHPVKALDFRTPLKAKIINIC-IWLLSSSVGISAIVLGGT--------KVRED 167 Query: 193 KDKYVCFDQFPSDSHRLS---YTTLLLVLQYFGPLCFIFICYFKIYIRLKR----RNNMM 245 D C QFP D + + + + P+ I +CY + +RLK N+ Sbjct: 168 VDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGNIF 227 Query: 246 DKMR 249 + +R Sbjct: 228 EMLR 231 Score = 73.2 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 28/106 (26%), Positives = 46/106 (43%), Gaps = 3/106 (2%) Query: 231 YFKIYIRLKRRNNMMDK--MRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDW 288 Y + R KR + + +RI ++L +V F VCW P+ IF V Sbjct: 362 YNQTPNRAKRVITTFRTGTWDAYREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEAL 421 Query: 289 NHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFF 334 +T + + C ++ +NPI Y FL++NF+R + F Sbjct: 422 GSTSHSTAALSS-YYFCIALGYTNSSLNPILYAFLDENFKRCFRDF 466 Score = 42.0 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 6/34 (17%), Positives = 13/34 (38%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHL 35 S ++Q N + + + A+ D +L Sbjct: 358 KSRWYNQTPNRAKRVITTFRTGTWDAYREKDRNL 391 >4XNV-A nrPDB Length = 421 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 75/356 (21%), Positives = 131/356 (36%), Gaps = 60/356 (16%) Query: 41 FTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVY 100 + L Y V I+G GN I + + + + ++ + NL+ +D L + F Y Sbjct: 51 YYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYY 110 Query: 101 TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW--RPNNRHAYVG 158 W+FG+AMCKL F+ V++ SI L I+ R+ ++ P R ++A Sbjct: 111 FNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICI 170 Query: 159 IAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLS--YTTLLL 216 ++W++ V + P L Y + +T C+D + R Y+ Sbjct: 171 SVLVWLIVVVAISPILFYSGTGVRKNKTIT---------CYDTTSDEYLRSYFIYSMCTT 221 Query: 217 VLQYFGPLCFIFICYFKIYI----RLKRRN--------NMMDKMRDNKYRSS-------- 256 V + PL I CY I ++K+ N D DN Sbjct: 222 VAMFCVPLVLILGCYGLIVRALIYKMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPD 281 Query: 257 --------------------ETKRINIMLLSIVVAFAVCWLPLTIFNTVF---DWNHQII 293 ++ +++ ++ FAV ++P + T+ + Q Sbjct: 282 DWVCPLCGVGKDQFEEVEEPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTP 341 Query: 294 ATCNHN----LLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDD 345 A C N + + A +++CVNPI Y F+R L RS + Sbjct: 342 AMCAFNDRVYATYQVTRGLASLNSCVNPILYFLAGDTFRRRLSRATRKASRRSEAN 397 >5N2S-A nrPDB Length = 436 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 64/319 (20%), Positives = 129/319 (40%), Gaps = 16/319 (5%) Query: 19 SEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNIL 78 + +NA + + A + + + ++ V GN+ +I + + +R+ T Sbjct: 98 TTRNAYIQKYLASSISAFQAAYIGIEV---LIALVSVPGNVLVIWAVKVNQALRDATFCF 154 Query: 79 IVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVER 138 IV+L+ +D+LV + +P + + F + P + SI +L+ IAV+R Sbjct: 155 IVSLAVADVLVGALVIPLAILINIGPQTYFHTCLMVACPVLILA--QSSILALLAIAVDR 212 Query: 139 HQLIINPRGWRP--NNRHAYVGIAVIWVLAVASSL-PFLIYQVMTDEPFQNVTLDAYKDK 195 + + P ++ R A V IA W+L+ L P + ++ + + Sbjct: 213 YLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAAAGSMGEP 272 Query: 196 YV-C-FDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKY 253 + C F++ S + + + + VL + I++ F + + + KY Sbjct: 273 VIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFALIRKQLNKKVSASSGDPQKY 332 Query: 254 RSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCN-HNLLFLLCHLTAMIS 312 E +I I FA+ WLPL I N + +C+ ++L + A + Sbjct: 333 YGKEL-KIAKSAALIAFLFALSWLPLHILNCI----TLFCPSCHKPSILTYIAIFLAHGN 387 Query: 313 TCVNPIFYGFLNKNFQRDL 331 + +NPI Y F + F+ Sbjct: 388 SAMNPIVYAFRIQKFRVTF 406 >6AKX-A nrPDB Length = 381 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 77/347 (22%), Positives = 135/347 (38%), Gaps = 66/347 (19%) Query: 42 TLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYT 101 L Y V I G GN+ +I+I++ K ++++T+I ++NL+ SDL ++ +PF Y Sbjct: 34 LLPPLYSLVFIFGFVGNMLVILILINYKRLKSMTDIYLLNLAISDLFF-LLTVPFWAHYA 92 Query: 102 LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGI-- 159 W FG MC+L + + IF ++L+ ++R+ +++ + R G+ Sbjct: 93 AA-QWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAV-FALKARTVTFGVVT 150 Query: 160 -AVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTL---L 215 + WV+AV +SLP +I+ E Y C FP ++ + Sbjct: 151 SVITWVVAVFASLPNIIFTRSQKEGLH----------YTCSSHFPYSQYQFWKNFQTLKI 200 Query: 216 LVLQYFGPLCFIFICYFKIYIRLKRRN-----------NMMDKMRDNK------------ 252 ++L PL + ICY I L R N D DN Sbjct: 201 VILGLVLPLLVMVICYSGILKTLLRMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPD 260 Query: 253 -----------------YRSSETKRINIMLLSIVVAFAVCWLPLTI------FNTVFDWN 289 + R ++ +I++ + + W P I F F N Sbjct: 261 DWVCPLCGVGKDQFEEVEEEKKRHRDVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLN 320 Query: 290 HQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFN 336 + ++ + + M C+NPI Y F+ + F+ L FF Sbjct: 321 N-CSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEEFRNYLLVFFQ 366 >4EJ4-A nrPDB Length = 461 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 60/223 (26%), Positives = 104/223 (46%), Gaps = 17/223 (7%) Query: 32 DCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAI 91 LA+ + Y AV +G+ GN+ ++ I++ +++ TNI I NL+ +D L A Sbjct: 6 RSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADAL-AT 64 Query: 92 MCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP---RGW 148 LPF LM+ W FGE +CK + ++ SIF+L +++V+R+ + +P + Sbjct: 65 STLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF 124 Query: 149 RPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHR 208 R + + I IWVLA +P ++ V VC QFPS S Sbjct: 125 RTPAKAKLINIC-IWVLASGVGVPIMVMAVTQPR----------DGAVVCMLQFPSPSWY 173 Query: 209 LSYT--TLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + + + P+ I +CY + +RL+ N+ + +R Sbjct: 174 WDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRNIFEMLR 216 Score = 72.4 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 29/107 (27%), Positives = 44/107 (41%), Gaps = 1/107 (0%) Query: 231 YFKIYIRLKRRNNMMD-KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWN 289 Y + R KR D + +RI M+L +V AF VCW P+ IF V+ Sbjct: 347 YNQTPNRAKRVITTFRTGTWDAYEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLV 406 Query: 290 HQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFN 336 LC ++ +NP+ Y FL++NF+R + Sbjct: 407 DINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCR 453 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 6/32 (18%), Positives = 12/32 (37%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDC 33 S ++Q N + + + A+E D Sbjct: 343 KSRWYNQTPNRAKRVITTFRTGTWDAYEKDRS 374 >5WB1-A nrPDB Length = 458 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 68/331 (20%), Positives = 129/331 (38%), Gaps = 34/331 (10%) Query: 41 FTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVY 100 YG V + G GN +I I ++ ++ ++ +NL+ +DLL + LP Y Sbjct: 42 PVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLF-VCTLPLWMQY 100 Query: 101 TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIA 160 L DH C L V++ S+ + IA++R+ I+ +RP + I Sbjct: 101 LL-DHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVY-MRYRPVKQACLFSI- 157 Query: 161 VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQY 220 W+ AV ++P V+T + Q +T + S+ + L++ + Sbjct: 158 FWWIFAVIIAIPHF--MVVTKKDNQCMT----------DYDYLEVSYPIILNVELMLGAF 205 Query: 221 FGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLT 280 PL I CY++I + + ++++ RI +L+++V+ F + WLP Sbjct: 206 VIPLSVISYCYYRISR--------IVAVSQSRHKG----RIVRVLIAVVLVFIIFWLPYH 253 Query: 281 --IFNTVFDWNHQIIATCNHN----LLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFF 334 +F I ++C +L A C+NP+ Y F+ F+++L Sbjct: 254 LTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCL 313 Query: 335 FNFCDFRSRDDDYETIAMSTMHTDVSKTSLK 365 R ++ + V Sbjct: 314 LAEFRLVPRGSGGSGGSLVPRGSQVQLVESG 344 >6MET-B nrPDB Length = 313 Score = 193 bits (491), Expect = 8e-50, Method: Composition-based stats. Identities = 74/307 (24%), Positives = 132/307 (42%), Gaps = 37/307 (12%) Query: 42 TLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYT 101 L Y V I G GN+ +I+I++ K ++++T+I ++NL+ SDL ++ +PF Y Sbjct: 32 LLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFF-LLTVPFWAHYA 90 Query: 102 LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGI-- 159 W FG MC+L + + IF ++L+ ++R+ +++ + R G+ Sbjct: 91 AA-QWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAV-FALKARTVTFGVVT 148 Query: 160 -AVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTL---L 215 + WV+AV +SLP +I+ E Y C FP ++ + Sbjct: 149 SVITWVVAVFASLPGIIFTRSQKEGLH----------YTCSSHFPYSQYQFWKNFQTLKI 198 Query: 216 LVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVC 275 ++L PL + ICY I L R N + R ++ +I++ + + Sbjct: 199 VILGLVLPLLVMVICYSGILKTLLRCRN-----------EKKRHRAVRLIFTIMIVYFLF 247 Query: 276 WLPLTI------FNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQR 329 W P I F F N+ ++ + + M C+NPI Y F+ + F+ Sbjct: 248 WAPYNIVLLLNTFQEFFGLNN-CSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRN 306 Query: 330 DLQFFFN 336 L FF Sbjct: 307 YLLVFFQ 313 >4DKL-A nrPDB Length = 464 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 54/214 (25%), Positives = 96/214 (44%), Gaps = 15/214 (7%) Query: 40 IFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFV 99 T+ Y V ++G+ GN ++ +I++ +M+ TNI I NL+ +D L A LPF V Sbjct: 17 AITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSV 75 Query: 100 YTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWR--PNNRHAYV 157 LM W FG +CK+ + ++ SIF+L ++V+R+ + +P R+A + Sbjct: 76 NYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKI 135 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRL--SYTTLL 215 W+L+ A LP + T + C F + + Sbjct: 136 VNVCNWILSSAIGLPVMFM----------ATTKYRQGSIDCTLTFSHPTWYWENLLKICV 185 Query: 216 LVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + + P+ I +CY + +RLK N+ + +R Sbjct: 186 FIFAFIMPVLIITVCYGLMILRLKSVRNIFEMLR 219 Score = 77.1 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 2/105 (1%) Query: 231 YFKIYIRLKRRNNMMD-KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWN 289 Y + R KR D + +RI M+L +V F VCW P+ I+ + Sbjct: 350 YNQTPNRAKRVITTFRTGTWDAYEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKAL- 408 Query: 290 HQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFF 334 I T + + C ++C+NP+ Y FL++NF+R + F Sbjct: 409 ITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREF 453 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 6/31 (19%), Positives = 12/31 (38%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDD 32 S ++Q N + + + A+E D Sbjct: 346 KSRWYNQTPNRAKRVITTFRTGTWDAYEKDR 376 >4XEE-A nrPDB Length = 541 Score = 188 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 53/330 (16%), Positives = 124/330 (37%), Gaps = 36/330 (10%) Query: 41 FTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMC---LPFT 97 + Y A+ ++G GN + + ++K ++++ + + +L L ++ +P Sbjct: 33 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVE 92 Query: 98 FVYT--LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNR 153 + W FG+A C+ F++ + ++ ++VER+ I +P + + Sbjct: 93 LYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRS 152 Query: 154 HAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTT 213 I+ IW+ + ++P L + + + VC + + ++ Sbjct: 153 RTKKFISAIWLASALLAIPMLFTMGLQNRS----ADGTHPGGLVCTPIVDTATVKVVIQV 208 Query: 214 LLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMD------------KMRDNKY-------R 254 + + P+ I I I +L + + + + R Sbjct: 209 NTFM-SFLFPMLVISILNTVIANKLTVMVHQAAEQGRVCTVGTHNGLEHSTFNMTIEPGR 267 Query: 255 SSETKRINIMLLSIVVAFAVCWLPLTIFNTVF----DWNHQIIATCNHNLLFLLCHLTAM 310 + ++L ++V+AF VCWLP + +F D ++ ++L + Sbjct: 268 VQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFY 327 Query: 311 ISTCVNPIFYGFLNKNFQRDLQFFFNF-CD 339 S+ +NPI Y ++ NF++ C Sbjct: 328 ASSAINPILYNLVSANFRQVFLSTLACLCP 357 Score = 41.2 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 4/27 (14%), Positives = 10/27 (37%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAF 28 S ++Q N + + + A+ Sbjct: 511 KSRWYNQTPNRAKRVITTFRTGTWDAY 537 >4ZJC-A nrPDB Length = 553 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 66/244 (27%), Positives = 121/244 (49%), Gaps = 2/244 (0%) Query: 24 QLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLS 83 + L + D P + L AY AV ++ + GN + + + + MR VTN IVNLS Sbjct: 38 EFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLS 97 Query: 84 FSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLII 143 +D+LV +CLP + + + + W+FG A+CK+ P++Q VS++V++ +L IA++R I Sbjct: 98 LADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAIC 157 Query: 144 NPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP 203 +P ++ R A I IW +++A +P + + + + VC +++ Sbjct: 158 HPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPE--LANRTRLFSVCDERWA 215 Query: 204 SDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINI 263 D + Y + ++ Y PL + + YF+I+ +L R + + Y + Sbjct: 216 DDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQGIDCSFWNESYLTGSRDERKK 275 Query: 264 MLLS 267 LLS Sbjct: 276 SLLS 279 Score = 93.2 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 22/90 (24%), Positives = 40/90 (44%), Gaps = 3/90 (3%) Query: 252 KYRSSETKRINIMLLSIVVAFAVCWLPLTIFNT---VFDWNHQIIATCNHNLLFLLCHLT 308 + ++ ML+ +++ FA+C+LP+++ N VF Q F H Sbjct: 450 SKQMRARRKTAKMLMVVLLVFALCYLPISVLNILKRVFGMFRQASDREAVYACFTFSHWL 509 Query: 309 AMISTCVNPIFYGFLNKNFQRDLQFFFNFC 338 ++ NPI Y FL+ F+ + F+ C Sbjct: 510 VYANSAANPIIYNFLSGKFREQFKAAFSCC 539 >4XT3-A nrPDB Length = 362 Score = 184 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 69/309 (22%), Positives = 128/309 (41%), Gaps = 36/309 (11%) Query: 41 FTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVY 100 YG V + G GN +I I ++ ++ ++ +NL+ +DLL + LP Y Sbjct: 42 PVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLF-VCTLPLWMQY 100 Query: 101 TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIA 160 L DH C L V++ S+ + IA++R+ I+ +RP + I Sbjct: 101 LL-DHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVY-MRYRPVKQACLFSI- 157 Query: 161 VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQY 220 W+ AV ++P V+T + Q +T + S+ + L++ + Sbjct: 158 FWWIFAVIIAIPHF--MVVTKKDNQCMT----------DYDYLEVSYPIILNVELMLGAF 205 Query: 221 FGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLT 280 PL I CY++I + + ++++ RI +L+++V+ F + WLP Sbjct: 206 VIPLSVISYCYYRISR--------IVAVSQSRHKG----RIVRVLIAVVLVFIIFWLPYH 253 Query: 281 --IFNTVFDWNHQIIATCNHN----LLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFF 334 +F I ++C +L A C+NP+ Y F+ F+++L Sbjct: 254 LTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCL 313 Query: 335 FNFCDFRSR 343 +FR R Sbjct: 314 LA--EFRQR 320 >5O9H-A nrPDB Length = 317 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 71/301 (23%), Positives = 125/301 (41%), Gaps = 27/301 (8%) Query: 41 FTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVY 100 + + V ++GV GN ++ + + R + I +NL+ +D L + Sbjct: 9 ILALVIFAVVFLVGVLGNALVVW-VTAFEAKRTINAIWFLNLAVADFLACLALPALFTSI 67 Query: 101 TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRH---AYV 157 HW FG A C + P + +++ SI L I+ +R L+ P W R A++ Sbjct: 68 VQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKP-AWCQRFRGAGLAWI 126 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRL-SYTTLLL 216 AV W LA+ ++P +Y+V+ +E F K +C + D R + + L Sbjct: 127 LCAVAWGLALLLTIPSALYRVVREEYF--------PPKVLCGVDYSHDKRRERAVAIVRL 178 Query: 217 VLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCW 276 VL + PL + ICY I +R R + + + +++++V +F + W Sbjct: 179 VLGFLWPLLTLTICYTFILLRTWSA------------RETRSTKTLKVVVAVVASFFIFW 226 Query: 277 LPLTIFNTVFDWNHQIIAT-CNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFF 335 LP + + + T L LC A I+ C+NPI Y + FQ + Sbjct: 227 LPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRERKSL 286 Query: 336 N 336 Sbjct: 287 P 287 >3UON-A nrPDB Length = 467 Score = 181 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 42/212 (19%), Positives = 101/212 (47%), Gaps = 12/212 (5%) Query: 40 IFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFV 99 + + L G++ ++ + GN+ +++ I + ++ V N + +L+ +DL++ + + + Sbjct: 23 VVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTL 82 Query: 100 YTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW--RPNNRHAYV 157 YT++ +W G +C L + V S+ +L++I+ +R+ + P + + + A + Sbjct: 83 YTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGM 142 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLV 217 IA WVL+ P +++ Q + + C+ QF S+ + T + Sbjct: 143 MIAAAWVLSFILWAPAILFW-------QFIVGVRTVEDGECYIQFFSN---AAVTFGTAI 192 Query: 218 LQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 ++ P+ + + Y+ I K R N+ + +R Sbjct: 193 AAFYLPVIIMTVLYWHISRASKSRINIFEMLR 224 Score = 81.3 bits (199), Expect = 7e-16, Method: Composition-based stats. Identities = 22/108 (20%), Positives = 43/108 (39%), Gaps = 5/108 (4%) Query: 231 YFKIYIRLKRRNNMMD-KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWN 289 Y + R KR D S K++ +L+I++AF + W P + + Sbjct: 355 YNQTPNRAKRVITTFRTGTWDAYPPPSREKKVTRTILAILLAFIITWAPYNVMVLI---- 410 Query: 290 HQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNF 337 + A C N ++ + + I++ +NP Y N F++ + Sbjct: 411 NTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMC 458 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 10/62 (16%), Positives = 21/62 (33%), Gaps = 2/62 (3%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 S ++Q N + + + A+ + T+ A II N+ + Sbjct: 351 KSRWYNQTPNRAKRVITTFRTGTWDAY--PPPSREKKVTRTILAILLAFIITWAPYNVMV 408 Query: 62 II 63 +I Sbjct: 409 LI 410 >4BWB-A nrPDB Length = 338 Score = 180 bits (457), Expect = 7e-46, Method: Composition-based stats. Identities = 59/311 (18%), Positives = 124/311 (39%), Gaps = 19/311 (6%) Query: 41 FTLALAYGAVIILGVSGNLALIIIILKQKEMRNVT---NILIVNLSFSDLLVAIMCLPFT 97 + Y A+ ++G GN + + ++K ++++ + + +L+ SDLL+ + LP Sbjct: 20 VLVTAIYLALFVVGTVGNGVTLFTLARKKSLQSLQSRVDYYLGSLALSDLLILLFALPVD 79 Query: 98 FVYT--LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNR 153 + W FG+A CK F++ + ++V ++VE + I +P + + Sbjct: 80 LYNFIWVHHPWAFGDAGCKGYYFLREACTYATALNVVSLSVELYLAICHPFKAKTLMSRS 139 Query: 154 HAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTT 213 I+ IW+ + ++P L QN++ D + + Sbjct: 140 RTKKFISAIWLASALLAIPMLFTM-----GLQNLSGDGTHPGGLVCTPIVDTATLRVVIQ 194 Query: 214 LLLVLQYFGPLCFIFICYFKIYIRLK---RRNNMMDKMRDNKYRSSETKRINIMLLSIVV 270 L + + P+ I RL + ++ R +R ++L ++V+ Sbjct: 195 LNTFMSFLFPMLVASILNTVAARRLTVMVHQAAEQGRVCTEPGRVQALRRGVLVLRAVVI 254 Query: 271 AFAVCWLPLTIFNTVF----DWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKN 326 AF VCWLP + +F D ++ ++L + +S +NPI Y ++ N Sbjct: 255 AFVVCWLPYHVRRLMFVYISDEQWTTALFDFYHYFYMLSNALVYVSAAINPILYNLVSAN 314 Query: 327 FQRDLQFFFNF 337 F++ Sbjct: 315 FRQVFLSTLAC 325 >2LNL-A nrPDB Length = 309 Score = 180 bits (457), Expect = 8e-46, Method: Composition-based stats. Identities = 65/312 (20%), Positives = 131/312 (41%), Gaps = 32/312 (10%) Query: 41 FTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVY 100 + + +AY V +L + GN ++++IL + R+VT++ ++NL+ + L+ + LP Sbjct: 21 YVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALA-DLLFALTLPIWAAS 79 Query: 101 TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIA 160 + + W+FG +CK+ ++ V+ I L I+V+R+ I++ RH + Sbjct: 80 KV-NGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVC 138 Query: 161 V-IWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDS--HRLSYTTLLLV 217 + W L++ SLPF +++ + VC++ +D+ R+ L Sbjct: 139 LGCWGLSMNLSLPFFLFRQAYHPNNSS---------PVCYEVLGNDTAKWRMVLRILPHT 189 Query: 218 LQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWL 277 + PL + CY L + + + R ++ ++V+ F +CWL Sbjct: 190 FGFIVPLFVMLFCYGFTLRTLFKAH------------MGQKHRAMRVIFAVVLIFLLCWL 237 Query: 278 PLTIFNTV--FDWNHQIIATC----NHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDL 331 P + I +C N + + +C+NPI Y F+ +NF+ Sbjct: 238 PYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGF 297 Query: 332 QFFFNFCDFRSR 343 S+ Sbjct: 298 LKILAMHGLVSK 309 >5LWE-A nrPDB Length = 331 Score = 180 bits (456), Expect = 9e-46, Method: Composition-based stats. Identities = 64/314 (20%), Positives = 120/314 (38%), Gaps = 37/314 (11%) Query: 43 LALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTL 102 L Y V I+G GN +I++ + T++ ++NL+ +DLL + + Sbjct: 29 LPPLYWLVFIVGALGNSLVILVYWYCARAKTATDMFLLNLAIADLLFLVTLPFWAIA--A 86 Query: 103 MDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRH----AYVG 158 D W F MCK+ + ++ + ++ I V+R+ I + + Sbjct: 87 ADQWKFQTFMCKVVNSMYKMNFYSCVLLIMCICVDRYIAIAQAMRAHTWREKRLLYSKMV 146 Query: 159 IAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSH---RLSYTTLL 215 IWVLA A +P ++Y + +E +C +PSD + + L Sbjct: 147 CFTIWVLAAALCIPEILYSQIKEE----------SGIAICTMVYPSDESTKLKSAVLALK 196 Query: 216 LVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVC 275 ++L +F P + CY I L + + S + ++++ F + Sbjct: 197 VILGFFLPFVVMACCYTIIIHTLI------------QAKKSSKHKALKATITVLTVFVLS 244 Query: 276 WLPLTIFNTV--FDWNHQIIATC----NHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQR 329 P V D I+ C ++ F + A +C+NP+ Y F+ + F+R Sbjct: 245 QFPYNCILLVQTIDAYAMFISNCAVSTAIDICFQVTQAIAFFHSCLNPVLYVFVGERFRR 304 Query: 330 DLQFFFNFCDFRSR 343 DL S+ Sbjct: 305 DLVKTLKNLGAISQ 318 >6DO1-A nrPDB Length = 425 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 48/213 (22%), Positives = 96/213 (45%), Gaps = 12/213 (5%) Query: 41 FTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVY 100 + Y + ++G+ GN ++I+I +++ V ++ ++NL+ +DL + + Sbjct: 36 VMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYT 95 Query: 101 TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRH--AYVG 158 + W FG +CK+ ++ S+F L ++++R+ I++P R A V Sbjct: 96 AMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVT 155 Query: 159 IAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLL-- 216 +IW+LA +SLP +I++ + N+T VC + S + L L Sbjct: 156 CIIIWLLAGLASLPAIIHRNVFFIENTNIT--------VCAFHYESQNSTLPIGLGLTKN 207 Query: 217 VLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 +L + P I Y I+ LK+ ++ D Sbjct: 208 ILGFLFPFLIILTSYTLIWKALKKAYDLEDNWE 240 Score = 63.6 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 27/111 (24%), Positives = 48/111 (43%), Gaps = 9/111 (8%) Query: 235 YIRLKRRNNMMDKMRDNKYRSSETKR--INIMLLSIVVAFAVCWLPLTIFNTVFDWNHQ- 291 + + R+ + + ++ + I ++++IV+ F W+P IF T D Q Sbjct: 316 VKEAQAAAEQLKTTRNAEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIF-TFLDVLIQL 374 Query: 292 -IIATC----NHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNF 337 II C + + A + C+NP+FYGFL K F+R + Sbjct: 375 GIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKY 425 >6J20-A nrPDB Length = 441 Score = 177 bits (449), Expect = 6e-45, Method: Composition-based stats. Identities = 70/242 (28%), Positives = 114/242 (47%), Gaps = 23/242 (9%) Query: 11 NHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKE 70 + ++ +N SE N + P I A AY +++ V GN+ ++ IIL K Sbjct: 11 SPNISTNTSEPNQFVQ---------PAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKR 61 Query: 71 MRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFS 130 MR VTN +VNL+F++ +A F Y + + W +G CK + F ++ SI+S Sbjct: 62 MRTVTNYFLVNLAFANASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIWS 121 Query: 131 LVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLD 190 + +A +R+ II+P R + V I VIWVLA+ + P Y T + Sbjct: 122 MTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYS----------TTE 171 Query: 191 AYKDKYVCFDQFPSDSHRLS---YTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDK 247 + VC ++P +++ Y + VL YF PL I Y + IRL +N+ + Sbjct: 172 TMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGIRLW-ASNIFEM 230 Query: 248 MR 249 +R Sbjct: 231 LR 232 Score = 92.9 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 31/105 (29%), Positives = 46/105 (43%), Gaps = 1/105 (0%) Query: 247 KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCH 306 + S +++ M++ +V FA+CWLP IF + N + ++L Sbjct: 338 TWDAYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIM 397 Query: 307 LTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIA 351 AM ST NPI Y LN F+ + F C F S DYE + Sbjct: 398 WLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFIS-AGDYEGLE 441 Score = 38.5 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 4/27 (14%), Positives = 10/27 (37%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAF 28 S ++Q N + + + A+ Sbjct: 316 KSRWYNQTPNRAKRVITTFRTGTWDAY 342 >5DSG-A nrPDB Length = 422 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 45/212 (21%), Positives = 98/212 (46%), Gaps = 12/212 (5%) Query: 40 IFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFV 99 + +A G++ ++ V GN+ +++ I ++++ V N + +L+ +DL++ + V Sbjct: 13 MVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTV 72 Query: 100 YTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW--RPNNRHAYV 157 Y + +W G +C L + V S+ +L++I+ +R+ + P + R + A + Sbjct: 73 YIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGL 132 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLV 217 IA WVL+ P +++ Q V CF QF S+ + T + Sbjct: 133 MIAAAWVLSFVLWAPAILFW-------QFVVGKRTVPDNQCFIQFLSNP---AVTFGTAI 182 Query: 218 LQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 ++ P+ + + Y I + + R N+ + +R Sbjct: 183 AAFYLPVVIMTVLYIHISLASRSRVNIFEMLR 214 Score = 78.6 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 17/108 (15%), Positives = 43/108 (39%), Gaps = 5/108 (4%) Query: 231 YFKIYIRLKRRNNMMD-KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWN 289 Y + R KR D ++ +++ + +I++AF + W P + V Sbjct: 302 YNQTPNRAKRVITTFRTGTWDAYQMAARERKVTRTIFAILLAFILTWTPYNVMVLV---- 357 Query: 290 HQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNF 337 + +C + ++ + + +++ +NP Y N F++ + Sbjct: 358 NTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLC 405 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 8/62 (12%), Positives = 22/62 (35%), Gaps = 2/62 (3%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 S ++Q N + + + A++ + T+ A I+ N+ + Sbjct: 298 KSRWYNQTPNRAKRVITTFRTGTWDAYQM--AARERKVTRTIFAILLAFILTWTPYNVMV 355 Query: 62 II 63 ++ Sbjct: 356 LV 357 >4U14-A nrPDB Length = 460 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 45/214 (21%), Positives = 98/214 (45%), Gaps = 13/214 (6%) Query: 38 AMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFT 97 + +A G + ++ + GN+ +I+ K+++ V N +++L+ +DL++ ++ + Sbjct: 10 WQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLF 69 Query: 98 FVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWR--PNNRHA 155 Y +M+ W G C L + V+ S+ +L++I+ +R+ I P +R + A Sbjct: 70 TTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRA 129 Query: 156 YVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLL 215 V I + WV++ P +++ Q CF QF S+ T Sbjct: 130 GVMIGLAWVISFVLWAPAILFW-------QYFVGKRTVPPGECFIQFLSEPT---ITFGT 179 Query: 216 LVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + ++ P+ + I Y++IY ++ N + +R Sbjct: 180 AIAAFYMPVTIMTILYWRIYKETEKM-NCFEMLR 212 Score = 74.8 bits (182), Expect = 7e-14, Method: Composition-based stats. Identities = 19/81 (23%), Positives = 34/81 (41%), Gaps = 4/81 (4%) Query: 257 ETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVN 316 + K+ L +I++AF + W P I V + +C + L + I++ VN Sbjct: 368 KEKKAAQTLSAILLAFIITWTPYNIMVLV----NTFCDSCIPKTYWNLGYWLCYINSTVN 423 Query: 317 PIFYGFLNKNFQRDLQFFFNF 337 P+ Y NK F+ + Sbjct: 424 PVCYALCNKTFRTTFKTLLLC 444 Score = 42.0 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 10/62 (16%), Positives = 22/62 (35%), Gaps = 4/62 (6%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 S ++Q N + + + A+ + TL+ A II N+ + Sbjct: 339 KSRWYNQCPNRAKRVITTFRTGTWDAYLIKEKKAAQ----TLSAILLAFIITWTPYNIMV 394 Query: 62 II 63 ++ Sbjct: 395 LV 396 >4U15-A nrPDB Length = 418 Score = 174 bits (441), Expect = 5e-44, Method: Composition-based stats. Identities = 45/214 (21%), Positives = 99/214 (46%), Gaps = 13/214 (6%) Query: 38 AMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFT 97 + +A G + ++ + GN+ +I+ K+++ V N +++L+ +DL++ ++ + Sbjct: 10 WQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLF 69 Query: 98 FVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWR--PNNRHA 155 Y +M+ W G C L + V+ S+ +L++I+ +R+ I P +R + A Sbjct: 70 TTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRA 129 Query: 156 YVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLL 215 V I + WV++ P +++ Q CF QF S+ T Sbjct: 130 GVMIGLAWVISFVLWAPAILFW-------QYFVGKRTVPPGECFIQFLSEPT---ITFGT 179 Query: 216 LVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + ++ P+ + I Y++IY ++ N+ + +R Sbjct: 180 AIAAFYMPVTIMTILYWRIYKETEKM-NIFEMLR 212 Score = 73.2 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 19/81 (23%), Positives = 34/81 (41%), Gaps = 4/81 (4%) Query: 257 ETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVN 316 + K+ L +I++AF + W P I V + +C + L + I++ VN Sbjct: 325 KEKKAAQTLSAILLAFIITWTPYNIMVLV----NTFCDSCIPKTYWNLGYWLCYINSTVN 380 Query: 317 PIFYGFLNKNFQRDLQFFFNF 337 P+ Y NK F+ + Sbjct: 381 PVCYALCNKTFRTTFKTLLLC 401 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 10/62 (16%), Positives = 22/62 (35%), Gaps = 4/62 (6%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 S ++Q N + + + A+ + TL+ A II N+ + Sbjct: 296 KSRWYNQTPNRAKRVITTFRTGTWDAYLIKEKKAAQ----TLSAILLAFIITWTPYNIMV 351 Query: 62 II 63 ++ Sbjct: 352 LV 353 >5T1A-A nrPDB Length = 508 Score = 174 bits (440), Expect = 7e-44, Method: Composition-based stats. Identities = 59/211 (27%), Positives = 105/211 (49%), Gaps = 17/211 (8%) Query: 42 TLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYT 101 L Y V I G GN+ +++I++ K+++ +T+I ++NL+ SDLL ++ LP + ++ Sbjct: 54 LLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLF-LITLPL-WAHS 111 Query: 102 LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGI-- 159 + WVFG AMCKL + + IF ++L+ ++R+ I++ + R G+ Sbjct: 112 AANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAV-FALKARTVTFGVVT 170 Query: 160 -AVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVL 218 + W++AV +S+P +I+ E YVC FP +T + +L Sbjct: 171 SVITWLVAVFASVPGIIFTKCQKE----------DSVYVCGPYFPRG-WNNFHTIMRNIL 219 Query: 219 QYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 PL + ICY I K R N+ + +R Sbjct: 220 GLVLPLLIMVICYSGISRASKSRINIFEMLR 250 Score = 83.2 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 26/113 (23%), Positives = 44/113 (38%), Gaps = 8/113 (7%) Query: 231 YFKIYIRLKRRNNMMD-KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTI------FN 283 Y + R KR D S K+ ++ +I++ + + W P I F Sbjct: 381 YNQTPNRAKRVITTFRTGTWDAYPPPSREKKAVRVIFTIMIVYFLFWTPYNIVILLNTFQ 440 Query: 284 TVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFN 336 F ++ +T + + M C+NPI Y F+ + F+R L FF Sbjct: 441 EFFGLSN-CESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRRYLSVFFR 492 Score = 46.6 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 9/63 (14%), Positives = 24/63 (38%), Gaps = 4/63 (6%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDD-CHLPLAMIFTLALAYGAVIILGVSGNLA 60 S ++Q N + + + A+ + +IFT+ + Y + N+ Sbjct: 377 KSRWYNQTPNRAKRVITTFRTGTWDAYPPPSREKKAVRVIFTIMIVY---FLFWTPYNIV 433 Query: 61 LII 63 +++ Sbjct: 434 ILL 436 >4BUO-A nrPDB Length = 335 Score = 174 bits (440), Expect = 7e-44, Method: Composition-based stats. Identities = 56/309 (18%), Positives = 126/309 (40%), Gaps = 17/309 (5%) Query: 41 FTLALAYGAVIILGVSGNLALIIIILKQKEMRNVT---NILIVNLSFSDLLVAIMCLPFT 97 + Y A+ ++G GN + + ++K ++++ + + +L+ SDLL+ ++ +P Sbjct: 19 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVDYYLGSLALSDLLILLLAMPVE 78 Query: 98 FVYT--LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNR 153 + W FG+A C+ F++ + ++V ++VE + I +P + + Sbjct: 79 LYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRS 138 Query: 154 HAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTT 213 I+ IW+ + ++P L + + + VC + + ++ Sbjct: 139 RTKKFISAIWLASALLAIPMLFTMGLQNLSGD----GTHPGGLVCTPIVDTATLKVVIQV 194 Query: 214 LLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMD-KMRDNKYRSSETKRINIMLLSIVVAF 272 + + P+ I I +L + M R +R ++L ++V+AF Sbjct: 195 NTFM-SFLFPMLVASILNTVIANKLTVMVHQAAFNMTIEPGRVQALRRGVLVLRAVVIAF 253 Query: 273 AVCWLPLTIFNTVF----DWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQ 328 VCWLP + +F D ++ ++L + +S +NPI Y ++ NF+ Sbjct: 254 VVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFR 313 Query: 329 RDLQFFFNF 337 + Sbjct: 314 QVFLSTLAC 322 >6D9H-R nrPDB Length = 389 Score = 174 bits (440), Expect = 8e-44, Method: Composition-based stats. Identities = 67/325 (20%), Positives = 129/325 (39%), Gaps = 21/325 (6%) Query: 36 PLAMIFTLALAYG----AVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAI 91 P I AY + ++ V GN+ +I + + +R+ T IV+L+ +D+ V Sbjct: 56 PPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA 115 Query: 92 MCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP- 150 + +P + + F + P + + SI +L+ IAV+R+ + P ++ Sbjct: 116 LVIPLAILINIGPQTYFHTCLMVACPVL--ILTQSSILALLAIAVDRYLRVKIPLRYKMV 173 Query: 151 -NNRHAYVGIAVIWVLAVASSL-PFLIYQVMTDEPFQNVTLDAYKDKYV-C-FDQFPSDS 206 R A V IA W+L+ L P + ++ + + + C F++ S Sbjct: 174 VTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISME 233 Query: 207 HRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLL 266 + + + + VL + I++ F + + + KY E +I L Sbjct: 234 YMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKEL-KIAKSLA 292 Query: 267 SIVVAFAVCWLPLTIFNTVFDWNHQIIATCN-HNLLFLLCHLTAMISTCVNPIFYGFLNK 325 I+ FA+ WLPL I N + +C+ ++L + ++ +NPI Y F + Sbjct: 293 LILFLFALSWLPLHILNCI----TLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQ 348 Query: 326 NFQRDLQFF----FNFCDFRSRDDD 346 F+ F D+D Sbjct: 349 KFRVTFLKIWNDHFRCQPAPPIDED 373 >5NDD-A nrPDB Length = 619 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 49/264 (18%), Positives = 102/264 (38%), Gaps = 23/264 (8%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPL---------AMIFTLALAYGAVII 52 S ++Q N + + + A+ + + L + Y V + Sbjct: 157 KSRWYNQTPNRAKRVITTFRTGTWDAYIYEFFSVDEFSASVLTGKLTTVFLPIVYTIVFV 216 Query: 53 LGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMD-HWVFGEA 111 + + N + + L + + + I + NL+ +DLL +++ P Y + +W++GEA Sbjct: 217 VALPSNGMALWVFLFRTKKKAPAVIYMANLALADLL-SVIWFPLKIAYHIHGNNWIYGEA 275 Query: 112 MCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAV-IWVLAVASS 170 +C + ++ SI L ++V+R I+NP G + +GI++ IW+L + + Sbjct: 276 LCNVLIGFFYANMYCSILFLTCLSVQRAWEIVNPMGHSRKKANIAIGISLAIWLLILLVT 335 Query: 171 LPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSD---SHRLSYTTLLLVLQYFGPLCFI 227 +P + + P +T C D P +Y L + + P Sbjct: 336 IPLYVVKQTIFIPALQIT--------TCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLT 387 Query: 228 FICYFKIYIRLKRRNNMMDKMRDN 251 Y + L + + + DN Sbjct: 388 ASAYVLMIRALADLEDNWETLNDN 411 Score = 54.3 bits (129), Expect = 8e-08, Method: Composition-based stats. Identities = 12/88 (13%), Positives = 39/88 (44%) Query: 255 SSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTC 314 + KR + +++ + +C+ P + V + + + L+++ + +++C Sbjct: 508 EKKRKRAIKLAVTVAAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSC 567 Query: 315 VNPIFYGFLNKNFQRDLQFFFNFCDFRS 342 ++P Y F++ +F+ + R+ Sbjct: 568 IDPFVYYFVSHDFRDHAKNALLCRSVRT 595 Score = 27.8 bits (60), Expect = 9.4, Method: Composition-based stats. Identities = 18/92 (19%), Positives = 34/92 (36%), Gaps = 10/92 (10%) Query: 19 SEKNAQLLAFENDDCHL---PLAMIFTLALAYGAVIILGVSGNLALI--IIILKQKEMRN 73 + +NA + + + + + T+A Y NL L+ ++K + + Sbjct: 494 TTRNAYIQKYLENSEKKRKRAIKLAVTVAAMYLICF---TPSNLLLVVHYFLIKSQGQSH 550 Query: 74 VTNILIVNLSFSDLLVAIMCLPFTFVYTLMDH 105 V + IV L S L PF + + D Sbjct: 551 VYALYIVALCLSTL--NSCIDPFVYYFVSHDF 580 >4IAR-A nrPDB Length = 401 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 49/223 (21%), Positives = 100/223 (44%), Gaps = 18/223 (8%) Query: 30 NDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLV 89 D LP ++ + LA + + N +I + + +++ N LI +L+ +DLLV Sbjct: 12 QDSISLPWKVLLVMLLA--LITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLV 69 Query: 90 AIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW- 148 +I+ +P + +YT+ W G+ +C T SI+ L +IA++R+ I + + Sbjct: 70 SILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYS 129 Query: 149 -RPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSH 207 + + A V IA++WV +++ SLP ++ E + C ++ Sbjct: 130 AKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEE----------EVSECVV----NTD 175 Query: 208 RLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRD 250 + YT V ++ P + Y +IY+ + R ++ + Sbjct: 176 HILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIADLEDNWE 218 Score = 83.6 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 22/87 (25%), Positives = 37/87 (42%), Gaps = 2/87 (2%) Query: 251 NKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAM 310 KY ++ ++ L I+ AF VCWLP I + V H +F Sbjct: 313 QKYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACW--FHLAIFDFFTWLGY 370 Query: 311 ISTCVNPIFYGFLNKNFQRDLQFFFNF 337 +++ +NPI Y N++F++ F Sbjct: 371 LNSLINPIIYTMSNEDFKQAFHKLIRF 397 >5ZKB-A nrPDB Length = 421 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 39/213 (18%), Positives = 98/213 (46%), Gaps = 12/213 (5%) Query: 40 IFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFV 99 + + L G++ ++ + GN+ +++ I + ++ V N + +L+ +DL++ + + + Sbjct: 25 VVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTL 84 Query: 100 YTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW--RPNNRHAYV 157 YT++ +W G +C L + V + +L++I+ +R+ + P + + + A + Sbjct: 85 YTVIGYWPLGPVVCDLWLALDYVVSNARVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGM 144 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLV 217 IA WVL+ P +++ Q + + C+ QF S+ + T + Sbjct: 145 MIAAAWVLSFILWAPAILFW-------QFIVGVRTVEDGECYIQFFSN---AAVTFGTAI 194 Query: 218 LQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRD 250 ++ P+ + + Y+ I K R ++ + Sbjct: 195 AAFYLPVIIMTVLYWHISRASKSRIADLEDNWE 227 Score = 80.5 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 37/83 (44%), Gaps = 4/83 (4%) Query: 255 SSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTC 314 S K++ +L+I++AF + W P + + + A C N ++ + + I++ Sbjct: 328 PSREKKVTRTILAILLAFIITWAPYNVMVLI----NTFCAPCIPNTVWTIGYWLCYINST 383 Query: 315 VNPIFYGFLNKNFQRDLQFFFNF 337 +NP Y N F++ + Sbjct: 384 INPACYALCNATFKKTFKHLLMC 406 >5CXV-A nrPDB Length = 515 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 46/215 (21%), Positives = 96/215 (44%), Gaps = 13/215 (6%) Query: 37 LAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPF 96 + + + G + + V+GNL ++I E++ V N +++L+ +DL++ + Sbjct: 47 PWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNL 106 Query: 97 TFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWR--PNNRH 154 Y LM HW G C L + V+ S+ +L+LI+ +R+ + P +R R Sbjct: 107 YTTYLLMGHWALGTLACDLWLALDYVASQASVMNLLLISFDRYFSVTRPLSYRAKRTPRR 166 Query: 155 AYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTL 214 A + I + W+++ P +++ Q + + C+ QF S T Sbjct: 167 AALMIGLAWLVSFVLWAPAILFW-------QYLVGERTVLAGQCYIQFLSQP---IITFG 216 Query: 215 LLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + ++ P+ + Y++IY + R N+ + +R Sbjct: 217 TAMAAFYLPVTVMCTLYWRIYRETENR-NIFEMLR 250 Score = 76.3 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 23/108 (21%), Positives = 40/108 (37%), Gaps = 5/108 (4%) Query: 231 YFKIYIRLKRRNNMMD-KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWN 289 Y + R KR D + + K+ L +I++AF + W P I V Sbjct: 381 YNQTPNRAKRVITTFRTGTWDAYFSLVKEKKAARTLSAILLAFILTWTPYNIMVLV---- 436 Query: 290 HQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNF 337 C L+ L + +++ +NP+ Y NK F+ + Sbjct: 437 STFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLC 484 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 9/67 (13%), Positives = 22/67 (32%), Gaps = 2/67 (2%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 S ++Q N + + + A+ TL+ A I+ N+ + Sbjct: 377 KSRWYNQTPNRAKRVITTFRTGTWDAYF--SLVKEKKAARTLSAILLAFILTWTPYNIMV 434 Query: 62 IIIILKQ 68 ++ + Sbjct: 435 LVSTFCK 441 >3PBL-A nrPDB Length = 481 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 55/214 (25%), Positives = 101/214 (47%), Gaps = 26/214 (12%) Query: 44 ALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLM 103 AL+Y A+I+ V GN + + +LK++ ++ TN L+V+L+ +DLLVA + +P+ + Sbjct: 42 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVT 101 Query: 104 DH-WVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNN-----RHAYV 157 W F C + + + T SI++L I+++R+ ++ P ++ R + Sbjct: 102 GGVWNFSRICCDVFVTLDVMMCTASIWNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVAL 161 Query: 158 GIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLV 217 I +WVLA A S P L T +P VC P + V Sbjct: 162 MITAVWVLAFAVSCPLLFGFNTTGDP------------TVCSISNPD------FVIYSSV 203 Query: 218 LQYFGPLCFIFICYFKIY--IRLKRRNNMMDKMR 249 + ++ P + Y +IY ++ +RR N+ + +R Sbjct: 204 VSFYLPFGVTVLVYARIYVVLKQRRRKNIFEMLR 237 Score = 71.7 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 22/109 (20%), Positives = 41/109 (37%), Gaps = 6/109 (5%) Query: 231 YFKIYIRLKRRNNMMD-KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWN 289 Y + R KR D K+ M+ ++ AF VCWLP + + + Sbjct: 368 YNQTPNRAKRVITTFRTGTWDAYGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVL---- 423 Query: 290 HQIIATCNH-NLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNF 337 + TC+ L+ +++ +NP+ Y N F++ + Sbjct: 424 NTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 472 Score = 41.6 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 7/55 (12%), Positives = 15/55 (27%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVS 56 S ++Q N + + + A+ + + L V L Sbjct: 364 KSRWYNQTPNRAKRVITTFRTGTWDAYGVPLREKKATQMVAIVLGAFIVCWLPFF 418 >3AYN-A nrPDB Length = 448 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 123/295 (41%), Gaps = 29/295 (9%) Query: 63 IIILKQKEMRNVTNILIVNLSFSDLLVAIMC-LPFTFVYTLMDHWVFGEAMCKLNPFVQC 121 + K K ++ N+ I+NL+FSD +++ P + + W+FG A CK+ F+ Sbjct: 57 YLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFLKKWIFGFAACKVYGFIGG 116 Query: 122 VSITVSIFSLVLIAVERHQLIINPRGW--RPNNRHAYVGIAVIWVLAVASSL-PFLIYQV 178 + +SI ++ +I+++R+ +I P + ++R A++ I +W+ +V ++ P + Sbjct: 117 IFGFMSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGA 176 Query: 179 MTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRL 238 T E FD DS S + +L +FGP+ IF CYF I + + Sbjct: 177 YTLEGVLC---------NCSFDYISRDSTTRSNILCMFILGFFGPILIIFFCYFNIVMSV 227 Query: 239 KRRNNMMD---------KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWN 289 M ++R + ++ R+ + + IV F + W P + + + Sbjct: 228 SNHEKEMAAMAKRLNAKELRKAQAGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFG 287 Query: 290 HQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFN----FCDF 340 T L + A S NP+ Y + F+ + F C F Sbjct: 288 PLEWVT---PYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPWVLTCCQF 339 >5V54-A nrPDB Length = 395 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 49/222 (22%), Positives = 99/222 (44%), Gaps = 18/222 (8%) Query: 30 NDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLV 89 D LP ++ + LA + + N +I + + +++ N LI +L+ +DLLV Sbjct: 5 QDSISLPWKVLLVMLLA--LITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLV 62 Query: 90 AIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW- 148 +I+ +P + +YT+ W G+ +C T SI+ L +IA++R+ I + + Sbjct: 63 SILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYS 122 Query: 149 -RPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSH 207 + + A V IA++WV +++ SLP ++ E + C ++ Sbjct: 123 AKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEE----------EVSECVV----NTD 168 Query: 208 RLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + YT V ++ P + Y +IY+ + R ++ Sbjct: 169 HILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIADLEDRW 210 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 20/84 (23%), Positives = 35/84 (41%), Gaps = 2/84 (2%) Query: 254 RSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMIST 313 ++ ++ L I+ AF VCWLP I + V H +F +++ Sbjct: 310 MAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACW--FHLAIFDFFTWLGYLNS 367 Query: 314 CVNPIFYGFLNKNFQRDLQFFFNF 337 +NPI Y N++F++ F Sbjct: 368 LINPIIYTMSNEDFKQAFHKLIRF 391 >3OE9-A nrPDB Length = 499 Score = 167 bits (424), Expect = 6e-42, Method: Composition-based stats. Identities = 48/211 (22%), Positives = 104/211 (49%), Gaps = 16/211 (7%) Query: 41 FTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVY 100 L Y + + G+ GN +I+++ QK++R++T+ ++LS +DLL ++ LPF V Sbjct: 49 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVD 107 Query: 101 TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNR--HAYVG 158 + + W FG +CK + V++ S++ L I+++R+ I++ + + V Sbjct: 108 AVAN-WYFGNFLCKAVHVIYTVNLYSSVWILAFISLDRYLAIVHATNSQRPRKLLAEKVV 166 Query: 159 IAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVL 218 +W+ A+ ++P I+ +++ D+Y+C +P+D + + +++ Sbjct: 167 YVGVWIPALLLTIPDFIFANVSE----------ADDRYICDRFYPNDLWVVVFQFQHIMV 216 Query: 219 QYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 P I CY I +L +N+ + +R Sbjct: 217 GLILPGIVILSCYCIIISKL--SHNIFEMLR 245 Score = 60.1 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 19/85 (22%), Positives = 33/85 (38%), Gaps = 6/85 (7%) Query: 257 ETKRINIMLLSIVVAFAVCWLPLTI-----FNTVFDWNHQIIATCNHNLLFL-LCHLTAM 310 + ++ + +++AF CWLP I + + Q N ++ + A Sbjct: 404 QKRKALKPTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAF 463 Query: 311 ISTCVNPIFYGFLNKNFQRDLQFFF 335 C+NPI Y FL F+ Q Sbjct: 464 FHCCLNPILYAFLGAKFKTSAQHAL 488 Score = 41.2 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 7/47 (14%), Positives = 15/47 (31%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYG 48 S ++Q N + + + A+ A+ T+ L Sbjct: 372 KSRWYNQTPNRAKRVITTFRTGTWDAYSGSGHQKRKALKPTVILILA 418 >4WW3-A nrPDB Length = 350 Score = 167 bits (422), Expect = 9e-42, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 123/295 (41%), Gaps = 29/295 (9%) Query: 63 IIILKQKEMRNVTNILIVNLSFSDLLVAIMC-LPFTFVYTLMDHWVFGEAMCKLNPFVQC 121 + K K ++ N+ I+NL+FSD +++ P + + W+FG A CK+ F+ Sbjct: 49 YLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFLKKWIFGFAACKVYGFIGG 108 Query: 122 VSITVSIFSLVLIAVERHQLIINPRGW--RPNNRHAYVGIAVIWVLAVASSL-PFLIYQV 178 + +SI ++ +I+++R+ +I P + ++R A++ I +W+ +V ++ P + Sbjct: 109 IFGFMSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGA 168 Query: 179 MTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRL 238 T E FD DS S + +L +FGP+ IF CYF I + + Sbjct: 169 YTLEGVLC---------NCSFDYISRDSTTRSNILCMFILGFFGPILIIFFCYFNIVMSV 219 Query: 239 KRRNNMMD---------KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWN 289 M ++R + ++ R+ + + IV F + W P + + + Sbjct: 220 SNHEKEMAAMAKRLNAKELRKAQAGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFG 279 Query: 290 HQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFN----FCDF 340 T L + A S NP+ Y + F+ + F C F Sbjct: 280 PLEWVT---PYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPWVLTCCQF 331 >6HLP-A nrPDB Length = 520 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 71/260 (27%), Positives = 115/260 (44%), Gaps = 23/260 (8%) Query: 11 NHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKE 70 + ++ +N SE N + P I A AY +++ V GN+ ++ IIL K Sbjct: 12 SPNISTNTSEPNQFVQ---------PAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKR 62 Query: 71 MRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFS 130 MR VTN +VN +F++ +A F Y + + W +G CK + F +I SI+S Sbjct: 63 MRTVTNYFLVNAAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAIFASIYS 122 Query: 131 LVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLD 190 + +A +R+ II+P R + V I VIWVLA+ + P Y T + Sbjct: 123 MTAVAFDRYMAIIHPLQPRLSLTATKVVICVIWVLALLLAFPQGYYS----------TTE 172 Query: 191 AYKDKYVCFDQFPSDSHRLS---YTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDK 247 + VC ++P +++ Y + VL YF PL I Y + I L+ + + Sbjct: 173 TMPSRVVCKIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYLYTVVGITLR-ASGIDCS 231 Query: 248 MRDNKYRSSETKRINIMLLS 267 + Y + LLS Sbjct: 232 FWNESYLTGSRDERKKSLLS 251 Score = 95.6 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 31/100 (31%), Positives = 46/100 (46%), Gaps = 1/100 (1%) Query: 252 KYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMI 311 + S +++ M++ +V FA+CWLP IF + N + ++L AM Sbjct: 422 SEQVSAARKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMS 481 Query: 312 STCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIA 351 ST NPI Y LN F+ + F C F S DYE + Sbjct: 482 STMYNPIIYCCLNDRFRLGFKHAFRCCPFIS-AGDYEGLE 520 >5UVI-A nrPDB Length = 447 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 50/233 (21%), Positives = 103/233 (44%), Gaps = 17/233 (7%) Query: 27 AFENDDCHLPLAMIFTLALAYGA-VIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFS 85 +++DD P M ++ + + +L + GN+ + + ++NVTN +V+L+ + Sbjct: 17 DYKDDDDGAPPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAA 76 Query: 86 DLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSI---TVSIFSLVLIAVERHQLI 142 D+ V ++ +PF + A C F+ C + SIFSL+ IA++R+ I Sbjct: 77 DIAVGVLAIPFAITISTGF-----CAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAI 131 Query: 143 INPRGWR--PNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEP--FQNVTLDAYKDKYVC 198 P + A IA+ WVL+ A L ++ +P +N + + + C Sbjct: 132 RIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVAC 191 Query: 199 -FDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRD 250 F+ ++ + + VL PL + Y +I++ +R+ ++ + Sbjct: 192 LFEDVVPMNYMVYFNFFACVL---VPLLLMLGVYLRIFLAARRQLADLEDNWE 241 Score = 76.7 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 29/111 (26%), Positives = 48/111 (43%), Gaps = 8/111 (7%) Query: 238 LKRRNNMMDKMRDNKYRSSETKRIN--IMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIAT 295 LK N + + RS+ K ++ L IV FA+CWLPL I N Sbjct: 327 LKTTRNAYIQKYLERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCF----TFFCPD 382 Query: 296 CNHNLLFL--LCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRD 344 C+H L+L L + + ++ VNP Y + + F++ + R ++ Sbjct: 383 CSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQE 433 >5WF6-A nrPDB Length = 504 Score = 164 bits (415), Expect = 5e-41, Method: Composition-based stats. Identities = 51/238 (21%), Positives = 106/238 (44%), Gaps = 23/238 (9%) Query: 27 AFENDDCHL------PLAMIFTLALAYGA-VIILGVSGNLALIIIILKQKEMRNVTNILI 79 +++DD + P M ++ + + +L + GN+ + + ++NVTN + Sbjct: 17 DYKDDDDAMGQPVGAPPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFV 76 Query: 80 VNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSI---TVSIFSLVLIAV 136 V+L+ +D+ V ++ +PF + A C F+ C + +IFSL+ IA+ Sbjct: 77 VSLAAADIAVGVLAIPFAITISTGF-----CAACHGCLFIACFVLVLTQSAIFSLLAIAI 131 Query: 137 ERHQLIINPRGWR--PNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEP--FQNVTLDAY 192 +R+ I P + A IA+ WVL+ A L ++ +P +N + Sbjct: 132 DRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCG 191 Query: 193 KDKYVC-FDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + + C F+ ++ + + VL PL + Y +I++ +R+ N+ + +R Sbjct: 192 EGQVACLFEDVVPMNYMVYFNFFACVL---VPLLLMLGVYLRIFLAARRQLNIFEMLR 246 Score = 77.5 bits (189), Expect = 9e-15, Method: Composition-based stats. Identities = 31/118 (26%), Positives = 50/118 (42%), Gaps = 8/118 (6%) Query: 231 YFKIYIRLKRRNNMMDKMRDNKYRSSETKRIN--IMLLSIVVAFAVCWLPLTIFNTVFDW 288 Y + R KR + YRS+ K ++ L IV FA+CWLPL I N Sbjct: 377 YNQTPNRAKRVITTFRTGTWDAYRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCF--- 433 Query: 289 NHQIIATCNHNLLFL--LCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRD 344 C+H L+L L + + ++ VNP Y + + F++ + R ++ Sbjct: 434 -TFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQE 490 Score = 41.2 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 11/104 (10%), Positives = 33/104 (31%), Gaps = 3/104 (2%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 S ++Q N + + + A+ + + +LA+ G + + ++ Sbjct: 373 KSRWYNQTPNRAKRVITTFRTGTWDAYRS-TLQKEVHAAKSLAIIVGLFALCWLPLHIIN 431 Query: 62 IIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDH 105 + ++ L+ + PF + Y + + Sbjct: 432 CFTFFCPDCSHAP--LWLMYLAIVLSHTNSVVNPFIYAYRIREF 473 >6N4B-R nrPDB Length = 495 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 71/329 (21%), Positives = 143/329 (43%), Gaps = 47/329 (14%) Query: 35 LPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRN-VTNILIVNLSFSDLLVAIMC 93 L + +A+ + V NL ++ +IL + +R + I +L+ +DLL +++ Sbjct: 126 LNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVI- 184 Query: 94 LPFTFVYTLMDHWVFGEAMCKLNPFVQ-----CVSITVSIFSLVLIAVERHQLIINPRGW 148 FVY+ +D VF + N F+ S T S+ SL L A++R+ I P + Sbjct: 185 ----FVYSFIDFHVFHRKDSR-NVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAY 239 Query: 149 RP--NNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP--S 204 + A V ++W +A+ ++ L+ K + VC D FP Sbjct: 240 KRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWN------------CEKLQSVCSDIFPHID 287 Query: 205 DSHRLSYTTLLLVLQYFGPLCFIFICY------FKIYIRLKRRNNMMDKMRDNKYRSSET 258 +++ + + + VL F +++I + ++ R +++ ++ D K + + Sbjct: 288 ETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRP 347 Query: 259 K------RINIMLLSIVVAFAVCWLPL--TIFNTVFDWNHQIIATCNHNLLFLLCHLTAM 310 R+ L+ I+V +CW PL + VF +++I T +F C + + Sbjct: 348 DQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKT-----VFAFCSMLCL 402 Query: 311 ISTCVNPIFYGFLNKNFQRDLQFFFNFCD 339 +++ VNPI Y +K+ + + F C+ Sbjct: 403 LNSTVNPIIYALRSKDLRHAFRSMFPSCE 431 >5XSZ-A nrPDB Length = 477 Score = 161 bits (407), Expect = 5e-40, Method: Composition-based stats. Identities = 59/228 (25%), Positives = 106/228 (46%), Gaps = 21/228 (9%) Query: 29 ENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLL 88 +ND+ PL ++ + V ++G+ N+A + I + ++RN T ++NL SDLL Sbjct: 22 KNDNFKYPLY-----SMVFSIVFMVGLITNVAAMYIFMCSLKLRNETTTYMMNLVVSDLL 76 Query: 89 VAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW 148 ++ LP Y + +W FG +CKL+ + ++ SI L I+V+R I+ P Sbjct: 77 F-VLTLPLRVFYFVQQNWPFGSLLCKLSVSLFYTNMYGSILFLTCISVDRFLAIVYPFRS 135 Query: 149 R--PNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDS 206 R R+A + A +WVL ++ SLP N T + CF+ F S Sbjct: 136 RGLRTKRNAKIVCAAVWVLVLSGSLPTGFM--------LNSTNKLENNSISCFENFSSKE 187 Query: 207 HRLSYTTLLLV---LQYFGPLCFIFICYFKIYIRLKRRN--NMMDKMR 249 + + +++ + + PL +C + L+R N N+ + +R Sbjct: 188 WKSHLSKVVIFIETVGFLIPLMLNVVCSAMVLQTLRRPNTVNIFEMLR 235 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 14/78 (17%), Positives = 30/78 (38%), Gaps = 5/78 (6%) Query: 257 ETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQ-----IIATCNHNLLFLLCHLTAMI 311 K+I M++ + F C++P + + A ++ + A+ Sbjct: 390 NKKKILRMIIVHLFIFCFCFIPYNVNLVFYSLVRTNTLKGCAAESVVRTIYPIALCIAVS 449 Query: 312 STCVNPIFYGFLNKNFQR 329 + C +PI Y F ++ Q Sbjct: 450 NCCFDPIVYYFTSETIQN 467 Score = 41.2 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 7/73 (9%), Positives = 24/73 (32%), Gaps = 8/73 (10%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSG-NL- 59 S ++Q N + + + A+ N I + + + + N+ Sbjct: 362 KSRWYNQTPNRAKRVITTFRTGTWDAYLN------KKKILRMIIVHLFIFCFCFIPYNVN 415 Query: 60 ALIIIILKQKEMR 72 + +++ ++ Sbjct: 416 LVFYSLVRTNTLK 428 >6CM4-A nrPDB Length = 430 Score = 161 bits (406), Expect = 7e-40, Method: Composition-based stats. Identities = 50/211 (23%), Positives = 95/211 (45%), Gaps = 24/211 (11%) Query: 44 ALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLM 103 A +I + V GN+ + + + ++K ++ TN LIV+L+ +DLLVA + +P+ ++ Sbjct: 4 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVV 63 Query: 104 DHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP---NNRHAYVGIA 160 W F C + + + T S +L I+++R+ + P + + R V I+ Sbjct: 64 GEWKFSRIHCDIFVTLDVMMCTASALNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIS 123 Query: 161 VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQY 220 ++WVL+ S P L D+ C P ++ ++ + Sbjct: 124 IVWVLSFTISCPLLFGLNNA-------------DQNECIIANP------AFVVYSSIVSF 164 Query: 221 FGPLCFIFICYFKIYIRLKRR--NNMMDKMR 249 + P + Y KIYI L+RR N+ + +R Sbjct: 165 YVPFIVTLLVYIKIYIVLRRRRKRNIFEMLR 195 Score = 70.1 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 32/91 (35%), Gaps = 4/91 (4%) Query: 247 KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCH 306 K + K+ M + F +CWLP I + + + +L+ Sbjct: 344 TWDAYKLSQQKEKKATQMAAIVAGVFIICWLPFFITHIL----NIHCDCNIPPVLYSAFT 399 Query: 307 LTAMISTCVNPIFYGFLNKNFQRDLQFFFNF 337 +++ VNPI Y N F++ + Sbjct: 400 WLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 430 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 8/52 (15%), Positives = 17/52 (32%), Gaps = 2/52 (3%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIIL 53 S ++Q N + + + A++ A +A V I+ Sbjct: 322 KSRWYNQTPNRAKRVITTFRTGTWDAYKLSQQKEKKATQ--MAAIVAGVFII 371 >5X33-A nrPDB Length = 523 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 49/237 (20%), Positives = 102/237 (43%), Gaps = 25/237 (10%) Query: 24 QLLAFENDD------CHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNI 77 +L+ +++DD +PL + L+++ ++G+ GN ++ ILK+ R+VT Sbjct: 1 ELMDYKDDDDKEFSNTFIPLLAMILLSVSM----VVGLPGNTFVVWSILKRMRKRSVTA- 55 Query: 78 LIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVE 137 L+V L ++ PF + W FG A C+L ++ VS+ S+ + ++++ Sbjct: 56 LMVLNLALADLAVLLTAPFFLHFLTWGTWSFGLAGCRLCHYICGVSMYASVLLITAMSLD 115 Query: 138 RHQLIINPRGWR--PNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDK 195 R + +P + A + IW + + P L ++ + + + Sbjct: 116 RSLAVASPFLSQKVRTKTAARWLLVGIWGASFLLATPVLAFRKV---------VKLTNET 166 Query: 196 YVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR---NNMMDKMR 249 +C +PSD H+ + + P + Y I RL+ R +N+ + +R Sbjct: 167 DLCLAVYPSDRHKAFHLLFEAFTGFVVPFLIVVASYADISRRLRARGSGSNIFEMLR 223 Score = 52.0 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 19/112 (16%), Positives = 38/112 (33%), Gaps = 9/112 (8%) Query: 264 MLLSIVVAFAVCWLPLTIFNTVFD----WNHQIIATCNHNLLFLLCHLTAMISTCVNPIF 319 +++ I++AFA WLP + + V + +C A +S+ VNP+ Sbjct: 391 LVVIIILAFAAFWLPYHVVDLVEGSRVLAGTLDQSKQQLRNARKVCIALAFLSSSVNPLL 450 Query: 320 YGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVA 371 Y R F ++ + + + + P+A Sbjct: 451 YACAGGGLLRSAGV-----GFVAKLLEATGAEAFSTRRGGTLAQTVKGIPMA 497 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 5/50 (10%), Positives = 13/50 (26%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVI 51 S ++Q N + + + A+ + L + Sbjct: 350 KSRWYNQTPNRAKRVITTFRTGTWDAYGSGSRFHRRRRTGRLVVIIILAF 399 >5ZKP-A nrPDB Length = 466 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 47/219 (21%), Positives = 90/219 (41%), Gaps = 9/219 (4%) Query: 30 NDDCHLPLAMIFTL-ALAYGAVIILGVSGNLALIIIILKQKEMR--NVTNILIVNLSFSD 86 +D H+ +TL + Y + +LGV N ++ + + + N I +VNL+ +D Sbjct: 6 HDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMAD 65 Query: 87 LLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR 146 +L I + Y +W+ + +C + + ++ S+ L +I R+Q + P Sbjct: 66 MLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVTRPI 125 Query: 147 G-WRPNNRHAYVGIA-VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPS 204 + N R + ++ VIWV V ++ FLI P + D + CF+ + Sbjct: 126 KTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGDVTR----CFEHYEK 181 Query: 205 DSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNN 243 S + + +V +F I C I L + Sbjct: 182 GSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQAK 220 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 14/81 (17%), Positives = 30/81 (37%), Gaps = 4/81 (4%) Query: 259 KRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLF----LLCHLTAMISTC 314 +R M +++ F +C++P + + + + + Sbjct: 370 RRDLWMACTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCV 429 Query: 315 VNPIFYGFLNKNFQRDLQFFF 335 +NP+ Y FL K F++ L F Sbjct: 430 LNPVIYCFLTKKFRKHLTEKF 450 >6DRY-A nrPDB Length = 411 Score = 151 bits (381), Expect = 5e-37, Method: Composition-based stats. Identities = 49/211 (23%), Positives = 99/211 (46%), Gaps = 16/211 (7%) Query: 44 ALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLM 103 AL VII + GN +I+ + +K+++ TN +++L+ +DLLV + +P + + Sbjct: 23 ALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMF 82 Query: 104 D-HWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVGIA 160 + W +C F+ + T SI+ L I+V+R+ I P + A++ I Sbjct: 83 EAMWPLPLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIKKPIQANQYNSRATAFIKIT 142 Query: 161 VIWVLAVASSLPFLIYQVMTDEPF-QNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQ 219 V+W++++ ++P I + TD N+T K+++ F F S + Sbjct: 143 VVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGS------------LAA 190 Query: 220 YFGPLCFIFICYFKIYIRLKRRNNMMDKMRD 250 +F PL + + YF L+++ ++ + Sbjct: 191 FFTPLAIMIVTYFLTIHALQKKAADLEDNWE 221 Score = 60.5 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 29/82 (35%), Gaps = 1/82 (1%) Query: 256 SETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCV 315 S +R + +L + F + W P I N +L + +S+ V Sbjct: 324 SNEQRASKVLGIVFFLFLLMWCPFFITNITLVL-CDSCNQTTLQMLLEIFVWIGYVSSGV 382 Query: 316 NPIFYGFLNKNFQRDLQFFFNF 337 NP+ Y NK F+ + Sbjct: 383 NPLVYTLFNKTFRDAFGRYITC 404 >6A94-A nrPDB Length = 376 Score = 151 bits (380), Expect = 7e-37, Method: Composition-based stats. Identities = 43/210 (20%), Positives = 95/210 (45%), Gaps = 17/210 (8%) Query: 44 ALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLM 103 AL VIIL ++GN+ +I+ + +K+++N TN +++L+ +D+L+ + +P + + L Sbjct: 12 ALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILY 71 Query: 104 DH-WVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVGIA 160 + W +C + ++ + T I+ L I+++R+ I NP + A++ I Sbjct: 72 GYRWPLPSKLCAVWIYLDVLFSTAKIWHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKII 131 Query: 161 VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQY 220 +W ++V S+P ++ + D D + + + + Sbjct: 132 AVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDN--------------FVLIGSFVSF 177 Query: 221 FGPLCFIFICYFKIYIRLKRRNNMMDKMRD 250 F PL + I YF L++ ++ + Sbjct: 178 FIPLTIMVITYFLTIKSLQKEAADLEDNWE 207 Score = 60.5 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 16/82 (19%), Positives = 29/82 (35%) Query: 256 SETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCV 315 S ++ +L + F V W P I N + + L + +S+ V Sbjct: 289 SNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAV 348 Query: 316 NPIFYGFLNKNFQRDLQFFFNF 337 NP+ Y NK ++ + Sbjct: 349 NPLVYTLFNKTYRSAFSRYIQC 370 >5XJM-A nrPDB Length = 422 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 54/213 (25%), Positives = 98/213 (46%), Gaps = 12/213 (5%) Query: 42 TLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYT 101 + + Y + ++G N+ ++ + QK + V++I I NL+ +DLL+ + Y+ Sbjct: 13 AIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYS 72 Query: 102 LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR-GWRPNNRHAYVGIA 160 W+FG MCK+ +++ SIF + ++V+R+Q +I P R N A + Sbjct: 73 YRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVP 132 Query: 161 VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLL---V 217 ++W +A SSLP + ++V Y C FP + + + L + Sbjct: 133 LVWCMACLSSLPTFYF--------RDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNI 184 Query: 218 LQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRD 250 L + PL FI CYF I L + N ++ + Sbjct: 185 LGFIIPLIFIATCYFGIRKHLLKTNADLEDNWE 217 Score = 76.7 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 5/84 (5%) Query: 258 TKRINIMLLSIVVAFAVCWLPLTI--FNTVFDWNHQIIATCNH---NLLFLLCHLTAMIS 312 ++ M ++V+AF +CWLP + F W I + +L L + Sbjct: 321 RDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTN 380 Query: 313 TCVNPIFYGFLNKNFQRDLQFFFN 336 +CVNP Y F+ FQ+ L+ F Sbjct: 381 SCVNPFLYCFVGNRFQQKLRSVFR 404 >5ZKQ-A nrPDB Length = 438 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 49/226 (21%), Positives = 95/226 (42%), Gaps = 10/226 (4%) Query: 30 NDDCHLPLAMIFTL-ALAYGAVIILGVSGNLALIIIILKQKEMR--NVTNILIVNLSFSD 86 +D H+ +TL + Y + +LGV N ++ + + + N I +VNL+ +D Sbjct: 6 HDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMAD 65 Query: 87 LLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR 146 +L I + Y +W+ + +C + + ++ S+ L +I R+Q + P Sbjct: 66 MLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVTRPI 125 Query: 147 G-WRPNNRHAYVGIA-VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPS 204 + N R + ++ VIWV V ++ FLI P + D + CF+ + Sbjct: 126 KTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGDVTR----CFEHYEK 181 Query: 205 DSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLK-RRNNMMDKMR 249 S + + +V +F I C I L + N+ + +R Sbjct: 182 GSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVNIFEMLR 227 Score = 54.7 bits (130), Expect = 6e-08, Method: Composition-based stats. Identities = 14/81 (17%), Positives = 30/81 (37%), Gaps = 4/81 (4%) Query: 259 KRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLF----LLCHLTAMISTC 314 +R M +++ F +C++P + + + + + Sbjct: 342 RRDLWMACTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCV 401 Query: 315 VNPIFYGFLNKNFQRDLQFFF 335 +NP+ Y FL K F++ L F Sbjct: 402 LNPVIYCFLTKKFRKHLTEKF 422 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 7/51 (13%), Positives = 17/51 (33%), Gaps = 1/51 (1%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVII 52 S ++Q N + + + A+ + L M T+ + + Sbjct: 311 KSRWYNQTPNRAKRVITTFRTGTWDAY-AEVKRRDLWMACTVLAVFIICFV 360 >3VW7-A nrPDB Length = 484 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 45/221 (20%), Positives = 91/221 (41%), Gaps = 17/221 (7%) Query: 36 PLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLP 95 + + Y V ++ + N+ I++ + + +++ + +++L+ +D+L + LP Sbjct: 16 SSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLF-VSVLP 74 Query: 96 FTFVYTLMD-HWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR---GWRPN 151 F Y W FG +C+ ++ SI + +I+++R ++ P WR Sbjct: 75 FKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTL 134 Query: 152 NRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPS---DSHR 208 R A IW LA+A +P L+ + P +T C D + + Sbjct: 135 GR-ASFTCLAIWALAIAGVVPLLLKEQTIQVPGLGIT--------TCHDVLSETLLEGYY 185 Query: 209 LSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 Y + + +F PL +CY I L N+ + +R Sbjct: 186 AYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSANIFEMLR 226 Score = 47.8 bits (112), Expect = 7e-06, Method: Composition-based stats. Identities = 16/102 (15%), Positives = 28/102 (27%), Gaps = 5/102 (4%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 S ++Q N + + + A+ N +F A + II N+ L Sbjct: 353 KSRWYNQTPNRAKRVITTFRTGTWDAYANRSKK--SRALFLSAAVFCIFIICFGPTNVLL 410 Query: 62 I--IIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYT 101 I L L ++ P + Y Sbjct: 411 IAHYSFLSHTST-TEAAYFAYLLCVCVSSISCCIDPLIYYYA 451 Score = 44.7 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 21/109 (19%), Positives = 39/109 (35%), Gaps = 2/109 (1%) Query: 231 YFKIYIRLKRRNNMMD-KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTV-FDW 288 Y + R KR D S+ R + ++ F +C+ P + + + Sbjct: 357 YNQTPNRAKRVITTFRTGTWDAYANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSF 416 Query: 289 NHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNF 337 T +LLC + IS C++P+ Y + + QR + Sbjct: 417 LSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCC 465 >6BQH-A nrPDB Length = 452 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 39/194 (20%), Positives = 89/194 (45%), Gaps = 16/194 (8%) Query: 60 ALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDH-WVFGEAMCKLNPF 118 +I+ + +K++ N TN +++L+ +D+LV ++ +P + + L D+ W +C + Sbjct: 60 LVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWIS 119 Query: 119 VQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVGIAVIWVLAVASSLPFLIY 176 + + T SI L I+++R+ I NP + A + IA++W +++ S+P + Sbjct: 120 LDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVI 179 Query: 177 QVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYI 236 + +E + + C P+ + + + +F PL + I Y Sbjct: 180 GLRDEEK-------VFVNNTTCVLNDPN------FVLIGSFVAFFIPLTIMVITYCLTIY 226 Query: 237 RLKRRNNMMDKMRD 250 L+R+ ++ + Sbjct: 227 VLRRQAADLEDNWE 240 Score = 64.7 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 13/82 (15%), Positives = 31/82 (37%) Query: 256 SETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCV 315 + ++ + +L + F + W P I N + + L + +++ + Sbjct: 342 NNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVNSGI 401 Query: 316 NPIFYGFLNKNFQRDLQFFFNF 337 NP+ Y NK ++R + Sbjct: 402 NPLVYTLFNKIYRRAFSNYLRC 423 >3RZE-A nrPDB Length = 452 Score = 144 bits (364), Expect = 4e-35, Method: Composition-based stats. Identities = 43/217 (19%), Positives = 96/217 (44%), Gaps = 12/217 (5%) Query: 35 LPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCL 94 + + L + + ++ V NL ++ + ++++ V N+ IV+LS +DL+V + + Sbjct: 3 MASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVM 62 Query: 95 PFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWR--PNN 152 P +Y LM W G +C + V+ T SIFS+ ++ ++R++ + P + Sbjct: 63 PMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTK 122 Query: 153 RHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYT 212 A I W L+ +P L + + + + + C F + + Sbjct: 123 TRASATILGAWFLSFLWVIPILGW-------NHFMQQTSVRREDKCETDFYDVTW---FK 172 Query: 213 TLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + ++ ++ P + Y KIY +++ N+ + +R Sbjct: 173 VMTAIINFYLPTLLMLWFYAKIYKAVRQHCNIFEMLR 209 Score = 73.2 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 24/103 (23%), Positives = 41/103 (39%), Gaps = 5/103 (4%) Query: 231 YFKIYIRLKRRNNMMD-KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWN 289 Y + R KR D + ++ L I+ AF +CW+P IF V Sbjct: 340 YNQTPNRAKRVITTFRTGTWDAYLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIA-- 397 Query: 290 HQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQ 332 C + L + I++ +NP+ Y N+NF++ + Sbjct: 398 --FCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 438 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 4/29 (13%), Positives = 11/29 (37%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A+ + Sbjct: 336 KSRWYNQTPNRAKRVITTFRTGTWDAYLH 364 >5NJ6-A nrPDB Length = 437 Score = 140 bits (353), Expect = 9e-34, Method: Composition-based stats. Identities = 45/216 (20%), Positives = 90/216 (41%), Gaps = 14/216 (6%) Query: 41 FTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVY 100 L + Y V ++ + N + + L + + + I + NL+ +DLL +++ P Y Sbjct: 23 VFLPIVYTIVFVVALPSNGMALWVFLFRTKKKAPAVIYMANLALADLL-SVIWFPLKIAY 81 Query: 101 TLMD-HWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGI 159 + +W++GEA+C + ++ SI L ++V+R I+NP G + +GI Sbjct: 82 HIHGNNWIYGEALCNVLIGFFYANMYCSILFLTCLSVQRAWEIVNPMGHSRKKANIAIGI 141 Query: 160 AV-IWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSD---SHRLSYTTLL 215 ++ IW+L + ++P + + P +T C D P +Y L Sbjct: 142 SLAIWLLILLVTIPLYVVKQTIFIPALQIT--------TCHDVLPEQLLVGDMFNYFLSL 193 Query: 216 LVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDN 251 + + P Y + L + + + DN Sbjct: 194 AIGVFLFPAFLTASAYVLMIRALADLEDNWETLNDN 229 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 12/88 (13%), Positives = 39/88 (44%) Query: 255 SSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTC 314 + KR + +++ + +C+ P + V + + + L+++ + +++C Sbjct: 326 EKKRKRAIKLAVTVAAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSC 385 Query: 315 VNPIFYGFLNKNFQRDLQFFFNFCDFRS 342 ++P Y F++ +F+ + R+ Sbjct: 386 IDPFVYYFVSHDFRDHAKNALLCRSVRT 413 >5GLH-A nrPDB Length = 498 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 55/223 (24%), Positives = 101/223 (45%), Gaps = 10/223 (4%) Query: 32 DCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAI 91 + + + V +LG+ GN L+ II K K MRN NILI +L+ DLL + Sbjct: 31 PIEIKETFKYINTVVSCLVFVLGIIGNSTLLYIIYKNKCMRNGPNILIASLALGDLLHIV 90 Query: 92 MCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPN 151 + +P L + W FG MCKL PF+Q S+ +++ SL ++++R++ + + + Sbjct: 91 IAIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGI 150 Query: 152 --NRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNV---TLDAYKDKYVCFDQFPSDS 206 + V I +IWV++V ++P I + ++ + + F QF Sbjct: 151 GVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQF---- 206 Query: 207 HRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + + L + PL Y + + R+ N+ + +R Sbjct: 207 YATAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRK-NIFEMLR 248 Score = 57.0 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 37/88 (42%), Gaps = 6/88 (6%) Query: 256 SETKRINIMLLSIVVAFAVCWLPLT---IFNTVFDWNHQIIATCNHNLLFLLCHL---TA 309 + + + + +V+ FA+CWLPL I + + L +L ++ A Sbjct: 407 KQRREVAKTVFCLVLVFALCWLPLHLARILKLTLYNQNDPNRCELLSFLLVLDYIGINMA 466 Query: 310 MISTCVNPIFYGFLNKNFQRDLQFFFNF 337 +++C NPI ++K F+ + Sbjct: 467 SLNSCANPIALYLVSKRFKNAFKSALCC 494 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 8/54 (14%), Positives = 19/54 (35%), Gaps = 3/54 (5%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGV 55 S ++Q N + + + A+ ND + T + V++ + Sbjct: 375 KSRWYNQTPNRAKRVITTFRTGTWDAYLNDHLKQRREVAKT---VFCLVLVFAL 425 >5GLI-A nrPDB Length = 464 Score = 134 bits (338), Expect = 4e-32, Method: Composition-based stats. Identities = 55/223 (24%), Positives = 101/223 (45%), Gaps = 10/223 (4%) Query: 32 DCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAI 91 + + + V +LG+ GN L+ II K K MRN NILI +L+ DLL + Sbjct: 31 PIEIKETFKYINTVVSCLVFVLGIIGNSTLLYIIYKNKCMRNGPNILIASLALGDLLHIV 90 Query: 92 MCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPN 151 + +P L + W FG MCKL PF+Q S+ +++ SL ++++R++ + + + Sbjct: 91 IAIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGI 150 Query: 152 --NRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNV---TLDAYKDKYVCFDQFPSDS 206 + V I +IWV++V ++P I + ++ + + F QF Sbjct: 151 GVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQF---- 206 Query: 207 HRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + + L + PL Y + + R+ N+ + +R Sbjct: 207 YATAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRK-NIFEMLR 248 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 37/88 (42%), Gaps = 6/88 (6%) Query: 256 SETKRINIMLLSIVVAFAVCWLPLT---IFNTVFDWNHQIIATCNHNLLFLLCHL---TA 309 + + + + +V+ FA+CWLPL I + + L +L ++ A Sbjct: 364 KQRREVAKTVFCLVLVFALCWLPLHLARILKLTLYNQNDPNRCELLSFLLVLDYIGINMA 423 Query: 310 MISTCVNPIFYGFLNKNFQRDLQFFFNF 337 +++C NPI ++K F+ + Sbjct: 424 SLNSCANPIALYLVSKRFKNAFKSALCC 451 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 8/54 (14%), Positives = 19/54 (35%), Gaps = 3/54 (5%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGV 55 S ++Q N + + + A+ ND + T + V++ + Sbjct: 332 KSRWYNQTPNRAKRVITTFRTGTWDAYLNDHLKQRREVAKT---VFCLVLVFAL 382 >6D26-A nrPDB Length = 470 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 45/221 (20%), Positives = 98/221 (44%), Gaps = 25/221 (11%) Query: 44 ALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLM 103 L +G +LG+ N ++ ++ + + V +++L+ SDLL + FT+ + Sbjct: 37 VLLHGLASLLGLVENGVILFVVGCRMR-QTVVTTWVLHLALSDLLASASLPFFTYFLAVG 95 Query: 104 DHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNR---HAYVGIA 160 W G CKL+ + +++ S F L I+++R ++ P W N+R A+ Sbjct: 96 HSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPV-WAQNHRTVAAAHKVCL 154 Query: 161 VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQF-----------PSDSHRL 209 V+W LAV +++P+ +++ T+ + +C+ +S + Sbjct: 155 VLWALAVLNTVPYFVFR---------DTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQA 205 Query: 210 SYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRD 250 + +L + PL I + + +RL+ R ++ + R+ Sbjct: 206 ALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRADLGLQHRN 246 Score = 41.2 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 4/28 (14%), Positives = 10/28 (35%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFE 29 S ++Q N + + + A+ Sbjct: 336 KSRWYNQTPNRAKRVITTFRTGTWDAYR 363 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 15/77 (19%), Positives = 25/77 (32%), Gaps = 5/77 (6%) Query: 275 CWLPLTIFNTVFDWNHQIIATCNHNLLF---LLCHLTAMISTCVNPIFYGFLNKNFQRDL 331 CW P +F+ + H L++ A ++ NP+ Y + R L Sbjct: 383 CWGPYHVFSLLEARAHA--NPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKL 440 Query: 332 QFFFNFCDFRSRDDDYE 348 + DD E Sbjct: 441 RRSLRTVLESVLVDDSE 457 >5UEN-A nrPDB Length = 416 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 42/212 (19%), Positives = 88/212 (41%), Gaps = 11/212 (5%) Query: 36 PLAMIFTLALAYG----AVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAI 91 P I AY + ++ V GN+ +I + + +R+ T IV+L+ +D+ V Sbjct: 2 PPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA 61 Query: 92 MCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP- 150 + +P + + F + P + + SI +L+ IAV+R+ + P ++ Sbjct: 62 LVIPLAILINIGPQTYFHTCLMVACPVL--ILTQSSILALLAIAVDRYLRVKIPLRYKMV 119 Query: 151 -NNRHAYVGIAVIWVLAVASSL-PFLIYQVMTDEPFQNVTLDAYKDKYV-C-FDQFPSDS 206 R A V IA W+L+ L P + ++ + + + C F++ S Sbjct: 120 VTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAAAGSMGEPVIKCEFEKVISME 179 Query: 207 HRLSYTTLLLVLQYFGPLCFIFICYFKIYIRL 238 + + + + VL + I++ F + + Sbjct: 180 YMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQ 211 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 21/109 (19%), Positives = 41/109 (37%), Gaps = 9/109 (8%) Query: 236 IRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIAT 295 ++ R + + + + +I L I+ FA+ WLPL I N + + Sbjct: 306 LKTTRNAYIQKYLERARSTLQKELKIAKSLALILFLFALSWLPLHILNCI----TLFCPS 361 Query: 296 CN-HNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFF----FNFCD 339 C+ ++L + ++ +NPI Y F + F+ F Sbjct: 362 CHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQP 410 >4GRV-A nrPDB Length = 510 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 33/216 (15%), Positives = 84/216 (38%), Gaps = 12/216 (5%) Query: 41 FTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMC---LPFT 97 + Y A+ ++G GN + + ++K ++++ + + +L L ++ +P Sbjct: 33 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVE 92 Query: 98 FVYT--LMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNR 153 + W FG+A C+ F++ + ++ ++V R+ I +P + + Sbjct: 93 LYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVARYLAICHPFKAKTLMSRS 152 Query: 154 HAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTT 213 I+ IW+ + ++P L + + + VC + + ++ Sbjct: 153 RTKKFISAIWLASALLAIPMLFTMGLQNRS----ADGTHPGGLVCTPIVDTATVKVVIQV 208 Query: 214 LLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + + P+ I I I +L N+ + +R Sbjct: 209 NTFM-SFLFPMLVISILNTVIANKLTVMVNIFEMLR 243 Score = 84.4 bits (207), Expect = 8e-17, Method: Composition-based stats. Identities = 20/89 (22%), Positives = 39/89 (43%), Gaps = 5/89 (5%) Query: 256 SETKRINIMLLSIVVAFAVCWLPLTIFNTVF----DWNHQIIATCNHNLLFLLCHLTAMI 311 + ++ ++V+AF VCWLP + +F D ++ ++L + A Sbjct: 402 QALRHGVLVARAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALAYA 461 Query: 312 STCVNPIFYGFLNKNFQRDLQFFFNF-CD 339 S+ +NPI Y ++ NF++ C Sbjct: 462 SSAINPILYNLVSANFRQVFLSTLACLCP 490 Score = 44.7 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 8/70 (11%), Positives = 22/70 (31%), Gaps = 9/70 (12%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLAL 61 S ++Q N + + + A+ + AL +G ++ V + Sbjct: 370 KSRWYNQTPNRAKRVITTFRTGTWDAYGSGS---------VQALRHGVLVARAVVIAFVV 420 Query: 62 IIIILKQKEM 71 + + + Sbjct: 421 CWLPYHVRRL 430 >5U09-A nrPDB Length = 508 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 50/243 (20%), Positives = 98/243 (40%), Gaps = 37/243 (15%) Query: 35 LPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRN-VTNILIVNLSFSDLLVAIMC 93 L + +A+ + V NL ++ +IL + +R + I +L+ +DLL +++ Sbjct: 23 LNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVI- 81 Query: 94 LPFTFVYTLMDHWVFGEAMCKLNPFVQ-----CVSITVSIFSLVLIAVERHQLIINPRGW 148 FVY+ +D VF + N F+ S T S+ SL L A++R+ I P + Sbjct: 82 ----FVYSFIDFHVFHRKDSR-NVFLFKLGGVTASFTASVGSLFLAAIDRYISIHRPLAY 136 Query: 149 RP--NNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP--S 204 + A V ++W +A+ ++ L+ K + VC D FP Sbjct: 137 KRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWN------------CEKLQSVCSDIFPHID 184 Query: 205 DSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIM 264 +++ + + + VL F +++I + + + + Y + Sbjct: 185 ETYLMFWIGVTSVLLLFIVYAYMYILW---------KAGIDCSFWNESYLTGSRDERKKS 235 Query: 265 LLS 267 LLS Sbjct: 236 LLS 238 Score = 61.3 bits (147), Expect = 8e-10, Method: Composition-based stats. Identities = 22/82 (26%), Positives = 41/82 (50%), Gaps = 7/82 (8%) Query: 260 RINIMLLSIVVAFAVCWLPL--TIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNP 317 R+ L+ I+V +CW PL + VF +++I T +F C + ++++ VNP Sbjct: 417 RLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKT-----VFAFCSMLCLLNSTVNP 471 Query: 318 IFYGFLNKNFQRDLQFFFNFCD 339 I Y +K+ + + F C+ Sbjct: 472 IIYALRSKDLRHAFRSMFPSCE 493 >5WIV-A nrPDB Length = 422 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 44/200 (22%), Positives = 84/200 (42%), Gaps = 21/200 (10%) Query: 46 AYGAVIILGVS--GNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLM 103 G V+++G GN + + + ++ ++ TN IV+L+ +DLL+A++ LP + Sbjct: 42 LVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQ 101 Query: 104 DH-WVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVGIA 160 W+ +C + + T SIF+L I+V+R + P + +R + I Sbjct: 102 GGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIG 161 Query: 161 VIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQY 220 W+L+ A + P L + +D VC + Y V + Sbjct: 162 ATWLLSAAVAAPVL----------CGLNDVRGRDPAVCRLE------DRDYVVYSSVCSF 205 Query: 221 FGPLCFIFICYFKIYIRLKR 240 F P + + Y+ + L+R Sbjct: 206 FLPCPLMLLLYWATFRGLQR 225 Score = 77.8 bits (190), Expect = 8e-15, Method: Composition-based stats. Identities = 15/85 (17%), Positives = 32/85 (37%), Gaps = 5/85 (5%) Query: 255 SSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCN-HNLLFLLCHLTAMIST 313 + ++ +L +V AF +CW P + + + C+ L +++ Sbjct: 341 TGRERKAMRVLPVVVGAFLLCWTPFFVVHI----TQALCPACSVPPRLVSAVTWLGYVNS 396 Query: 314 CVNPIFYGFLNKNFQRDLQFFFNFC 338 +NP+ Y N F+ + C Sbjct: 397 ALNPVIYTVFNAEFRNVFRKALRAC 421 >5XRA-A nrPDB Length = 438 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 46/207 (22%), Positives = 90/207 (43%), Gaps = 28/207 (13%) Query: 35 LPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRN-VTNILIVNLSFSDLLVAIMC 93 L + +A+ + V NL ++ +IL + +R + I +L+ +DLL +++ Sbjct: 13 LNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVI- 71 Query: 94 LPFTFVYTLMDHWVFGEAMCKLNPFVQ-----CVSITVSIFSLVLIAVERHQLIINPRGW 148 FVY+ +D VF + N F+ S T S+ SL L A++R+ I P + Sbjct: 72 ----FVYSFIDFHVFHRKDSR-NVFLFKLGGVTASFTASVGSLFLAAIDRYISIHRPLAY 126 Query: 149 RP--NNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP--S 204 + A V ++W +A+ ++ L+ K + VC D FP Sbjct: 127 KRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWN------------CEKLQSVCSDIFPHID 174 Query: 205 DSHRLSYTTLLLVLQYFGPLCFIFICY 231 ++ + + ++ VL F +++I + Sbjct: 175 KTYLMFWIGVVSVLLLFIVYAYMYILW 201 Score = 55.9 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 17/65 (26%), Positives = 31/65 (47%), Gaps = 7/65 (10%) Query: 275 CWLPL--TIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQ 332 CW PL + VF +++I T +F C + ++++ VNPI Y +K+ + + Sbjct: 379 CWGPLLAIMVYDVFGKMNKLIKT-----VFAFCSMLCLLNSTVNPIIYALRSKDLRHAFR 433 Query: 333 FFFNF 337 F Sbjct: 434 SMFPS 438 >5YWY-A nrPDB Length = 332 Score = 100 bits (250), Expect = 7e-22, Method: Composition-based stats. Identities = 46/286 (16%), Positives = 101/286 (35%), Gaps = 24/286 (8%) Query: 48 GAVIILGVSGNLALIIIILKQKEMRNVTNIL--IVNLSFSDLLVAIMCLPFTFVYTLMDH 105 + I GV GNL I+++ K ++ + T + L +DLL ++ P T + Sbjct: 25 AVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLLVTDLLGTLLVSPVTIATYMKGQ 84 Query: 106 WVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVGIAVIW 163 W G+ +C+ + F+ + + ++VER+ I + + + R A + + ++ Sbjct: 85 WPGGQPLCEYSTFILLFFSLSRLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVY 144 Query: 164 VLAVA-SSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSD--SHRLSYTTLLLVLQY 220 V +LP + + CF + + +H + Sbjct: 145 ASNVLFCALPNMGLGSSRLQY----------PDTWCFIDWTTQVTAHAAYSYMYAGFSSF 194 Query: 221 FGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLT 280 +C + L R + + + ++ I+L++ + +C +PL Sbjct: 195 LI--LATVLCNVLVCGALLRMHRQF-----FRRIAGAEIQMVILLIATSLVVLICSIPLV 247 Query: 281 IFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKN 326 + V + L A ++ ++P Y L K Sbjct: 248 VRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKT 293 >4NTJ-A nrPDB Length = 466 Score = 98.3 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 46/258 (17%), Positives = 85/258 (32%), Gaps = 33/258 (12%) Query: 27 AFENDDCHLPLAM--------------------IFTLALAYGAVIILGVSGNLALIIIIL 66 +++DD P A+ L Y + +G+ N + I Sbjct: 1 DYKDDDDGAPQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFF 60 Query: 67 KQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLM-DHWVFGEAMCKLNPFVQCVSIT 125 + + N I + N SDLL+ I+ PF + +C++ + ++ Sbjct: 61 QIRSKSNFI-IFLKNTVISDLLM-ILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMY 118 Query: 126 VSIFSLVLIAVERHQLIINPRGWRPNNR--HAYVGIAVIWVLAVASSLPFLIYQVMTDEP 183 +SI L LI ++R+Q P A + VIW SLP +I Sbjct: 119 ISISFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRD 178 Query: 184 FQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNN 243 K +F H + ++ ++ + +CY I L R Sbjct: 179 KNVKKCSFLKS------EFGLVWHEIVNYICQVI--FWINFLIVIVCYTLITKELYRSYV 230 Query: 244 MMDKMRDNKYRSSETKRI 261 + DN ++ ++ Sbjct: 231 RTADLEDNWETLNDNLKV 248 Score = 61.3 bits (147), Expect = 8e-10, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 33/85 (38%), Gaps = 5/85 (5%) Query: 258 TKRINIMLLSIVVAFAVCWLPLTIFNT--VFDWNHQIIATCNHNLLFLL---CHLTAMIS 312 K++N+ + I+ F +C++P + N LF + ++ Sbjct: 346 RKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLN 405 Query: 313 TCVNPIFYGFLNKNFQRDLQFFFNF 337 C+NP Y FL K+F+ L Sbjct: 406 ACLNPFIYFFLCKSFRNSLISMLKC 430 >4PHU-A nrPDB Length = 491 Score = 89.8 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 45/240 (18%), Positives = 79/240 (32%), Gaps = 23/240 (9%) Query: 26 LAFENDDCH------LPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMR-NVTNIL 78 + +++DD LP + F L Y A LG N+ I +R + + Sbjct: 1 MDYKDDDDKGSATMDLPPQLSFGL---YVAAFALGFPLNVLAIRGATAHARLRLTPSAVY 57 Query: 79 IVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVER 138 +NL SDLL+ + W ++C + + L ++ R Sbjct: 58 ALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFAPLYAGGGFLAALSAAR 117 Query: 139 HQLIINPRGWRPNNRHAYV--GIAVIWV-------LAVASSLPFLIYQVMTDEPFQNVTL 189 + P G++ R Y A IW L P N + Sbjct: 118 YLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPV 177 Query: 190 DAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMR 249 + VC + + S + +L L+L + L C+ L R +N+ + +R Sbjct: 178 N---GSPVCLEAWDPASAGPARFSLSLLLFFLP-LAITAFCFVGCLRALARGSNIFEMLR 233 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 4/27 (14%), Positives = 10/27 (37%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAF 28 S ++Q N + + + A+ Sbjct: 360 KSRWYNQTPNRAKRVITTFRTGTWDAY 386 >6AK3-B nrPDB Length = 418 Score = 87.5 bits (215), Expect = 8e-18, Method: Composition-based stats. Identities = 49/289 (16%), Positives = 93/289 (32%), Gaps = 22/289 (7%) Query: 52 ILGVSGNLALIIIILKQKEMRNVT--NILIVN---LSFSDLLVAIMCLPFTFVYTLMDH- 105 + G GN ++++ + R ++ L+ +DL+ ++ P V L Sbjct: 22 LTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQR 81 Query: 106 W----VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVGI 159 W G +C V S+F +AVER I P + R + Sbjct: 82 WEHIDPSGR-LCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRITRAVL 140 Query: 160 AVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQ 219 +W+ ++A +L ++ + + + L + + L Sbjct: 141 LGVWLASLAFALLPVLGVGQYTVQWPGTWCFISTGRGGQGTSSSHNWGNLFFASAFAFLG 200 Query: 220 YFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYR-SSETKRINIMLLSIVVAFAVCWLP 278 L F C L R + + T I L+ I++ +VCW P Sbjct: 201 LLA-LTVTFSCNLATIKALVDRCRAKATASQSSAQWGRITTETAIQLMGIMLVLSVCWSP 259 Query: 279 LTIFNTVFDWNHQIIATCNHNL-------LFLLCHLTAMISTCVNPIFY 320 L I + + C + FL+ A ++ ++P Y Sbjct: 260 LLIMMLKMIFQQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVY 308 >3V2Y-A nrPDB Length = 520 Score = 84.8 bits (208), Expect = 6e-17, Method: Composition-based stats. Identities = 43/208 (20%), Positives = 84/208 (40%), Gaps = 20/208 (9%) Query: 44 ALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLM 103 ++ + + + N+ +++ I K K+ I NL+ SDLL + + + Sbjct: 67 SVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV-AYTANLLLSGA 125 Query: 104 DHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP-RGWRPNNRHAYVGIAVI 162 + A L V+++ S+FSL+ IA+ER+ ++ NN ++ I+ Sbjct: 126 TTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISAC 185 Query: 163 WVLAVAS-SLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYF 221 WV+++ LP + + ++ + L Y H+ V + Sbjct: 186 WVISLILGGLPIMGWNCISALSSCSTVLPLY--------------HKHYILFCTTV--FT 229 Query: 222 GPLCFIFICYFKIYIRLKRRNNMMDKMR 249 L I I Y +IY L R N+ + +R Sbjct: 230 LLLLSIVILYCRIY-SLVRTRNIFEMLR 256 Score = 52.4 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 20/79 (25%), Positives = 33/79 (41%), Gaps = 4/79 (5%) Query: 254 RSSETKRINIMLLSIVVAFAVCWLPLTIFNTV-FDWNHQIIATCNHNLLFLLCHLTAMIS 312 RSSE + ++ ++ F CW PL I + + FL+ A+++ Sbjct: 412 RSSENVALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLV---LAVLN 468 Query: 313 TCVNPIFYGFLNKNFQRDL 331 + NPI Y NK +R Sbjct: 469 SGTNPIIYTLTNKEMRRAF 487 Score = 41.6 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 9/55 (16%), Positives = 19/55 (34%), Gaps = 7/55 (12%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVS 56 S ++Q N + + + A+ + +AL +I+L V Sbjct: 383 KSRWYNQTPNRAKRVITTFRTGTWDAYASRSSE-------NVALLKTVIIVLSVF 430 >5ZTY-A nrPDB Length = 500 Score = 81.3 bits (199), Expect = 6e-16, Method: Composition-based stats. Identities = 43/230 (18%), Positives = 92/230 (40%), Gaps = 35/230 (15%) Query: 31 DDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRN-VTNILIVNLSFSDLLV 89 D L +A+ + +L N+A++ +IL ++R + + I +L+ +D L Sbjct: 23 DYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLALADFLA 82 Query: 90 AIMCLPFTFVYTLMDHWVFGEAMCKLNPFV----QCVSITVSIFSLVLIAVERHQLIINP 145 +++ F + ++ VF K + ++ T S+ SL+L A++R+ + P Sbjct: 83 SVV-----FACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLAAIDRYLCLRYP 137 Query: 146 RGWR--PNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP 203 ++ A V + ++WVL+ S L+ P C + FP Sbjct: 138 PSYKALLTRGRALVLLGIMWVLSALVSYLPLMGWTCCPRP--------------CSELFP 183 Query: 204 --SDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR--RNNMMDKMR 249 + + LS+ + L I Y + + + +N+ + +R Sbjct: 184 LIPNDYLLSWLLFIAFL-----FSGIIYTYGHVLWKAHQHVASNIFEMLR 228 Score = 50.9 bits (120), Expect = 9e-07, Method: Composition-based stats. Identities = 17/104 (16%), Positives = 33/104 (31%), Gaps = 4/104 (3%) Query: 231 YFKIYIRLKRRNNMMD-KMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWN 289 Y + R KR D R + L ++ +CW P + + Sbjct: 359 YNQTPNRAKRVITTFRTGTWDAYARMRLDVELAKTLGLVLAVLLICWFP---VLALMAHS 415 Query: 290 HQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQF 333 + F C + +I++ VNP+ Y ++ + Sbjct: 416 LATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSEEIRSSAHH 459 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 9/50 (18%), Positives = 17/50 (34%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVI 51 S ++Q N + + + A+ + LA L LA + Sbjct: 355 KSRWYNQTPNRAKRVITTFRTGTWDAYARMRLDVELAKTLGLVLAVLLIC 404 >4Z36-A nrPDB Length = 459 Score = 74.4 bits (181), Expect = 8e-14, Method: Composition-based stats. Identities = 42/219 (19%), Positives = 76/219 (34%), Gaps = 34/219 (15%) Query: 28 FENDDCHLPLAMIFTLALAYGA---VIILGVSGNLALIIIILKQKEMRNVTNILIVNLSF 84 + HL L G V I + NL +++ I + L+ NL+ Sbjct: 52 YNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAA 111 Query: 85 SDLLVAIMCLPFTFVY------TLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVER 138 +D + F + W+ + + S+T S+ +L+ IA+ER Sbjct: 112 ADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQ-------GLIDTSLTASVANLLAIAIER 164 Query: 139 HQLIINP-RGWRPNNRHAYVGIAVIWVLAVAS-SLPFLIYQVMTDEPFQNVTLDAYKDKY 196 H + R +NR V I VIW +A+ ++P + + + D Y Sbjct: 165 HITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIEN----CSNMAPLY 220 Query: 197 VCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIY 235 C S+ + + LV + + Y I+ Sbjct: 221 SC-------SYLVFWAIFNLVT-----FVVMVVLYAHIF 247 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 33/75 (44%), Gaps = 8/75 (10%) Query: 261 INIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFY 320 + ++ ++ AF +CW P + + Q + FLL A ++ +NPI Y Sbjct: 360 LLKTVVIVLGAFIICWTPGLVLLLLDCCCPQ-CDVLAYEKFFLL---LAEFNSAMNPIIY 415 Query: 321 GFLNKN----FQRDL 331 + +K F++ L Sbjct: 416 SYRDKEMSATFRQIL 430 >6M9T-A nrPDB Length = 537 Score = 69.0 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 35/211 (16%), Positives = 68/211 (32%), Gaps = 15/211 (7%) Query: 52 ILGVSGNLALIIIILKQKEMRNVT--NILIVN---LSFSDLLVAIMCLPFTFVYTLMDH- 105 + G GN ++++ + R ++ L+ +DL+ ++ P V L Sbjct: 72 LTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQR 131 Query: 106 W----VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRP--NNRHAYVGI 159 W G +C V S+F +AVER I P + R + Sbjct: 132 WEHIDPSGR-LCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVL 190 Query: 160 AVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQ 219 +W+ +A +L ++ + + + L + + L Sbjct: 191 LGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLG 250 Query: 220 YFGPLCFIFICYFKIYIRLKRR-NNMMDKMR 249 L F C L R +N+ + +R Sbjct: 251 LLA-LTVTFSCNLATIKALVSRGSNIFEMLR 280 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 22/86 (25%), Positives = 35/86 (40%), Gaps = 7/86 (8%) Query: 258 TKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL-------LFLLCHLTAM 310 T I L++I+ +VCW PL I +N + C + FL+ A Sbjct: 440 TTETAIQLMAIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLAS 499 Query: 311 ISTCVNPIFYGFLNKNFQRDLQFFFN 336 ++ ++P Y L K R L+ F Sbjct: 500 LNQILDPWVYLLLRKILGRPLEVLFQ 525 Score = 42.0 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 4/27 (14%), Positives = 10/27 (37%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAF 28 S ++Q N + + + A+ Sbjct: 407 KSRWYNQTPNRAKRVITTFRTGTWDAY 433 >6IIU-A nrPDB Length = 484 Score = 59.7 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 58/384 (15%), Positives = 111/384 (28%), Gaps = 72/384 (18%) Query: 19 SEKNAQLLAFEN----DDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQK----E 70 + +NA + + + L + + ++G++ NL + ++ + Sbjct: 106 TTRNAYIQKYLPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSH 165 Query: 71 MRNVTNILIVNLSFSDLLVAIMCLPFTFV-YTLMDHWVFGEAMCKLNPFVQCVSIT--VS 127 R+ + L +D L ++ + + W + C+L F+ V I +S Sbjct: 166 TRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLS 225 Query: 128 IFSL-VLIAVERHQLIINPRG--WRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPF 184 L +A ER+ I P + R A W L ++ Sbjct: 226 PLLLGAAMASERYLGITRPFSRPAVASQRRA-------WATVGLVWAAALALGLLPLLGV 278 Query: 185 QNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQ------YFGPLCFIFICYFKIYIRL 238 T+ CF ++S +++ L +L F +Y + Sbjct: 279 GRYTVQY--PGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGM 336 Query: 239 KRRN--------NMMDKMRDNKYRSS-----------------------------ETKRI 261 K+ N D DN + Sbjct: 337 KKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQFEEVEERDSEVEM 396 Query: 262 NIMLLSIVVAFAVCWLPLTIFNT-VFDWNHQIIATCNHNLLFLLCHLTAMI-----STCV 315 L I+V +VCWLPL +F N ++ L + + + Sbjct: 397 MAQALGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQIL 456 Query: 316 NPIFYGFLNKNFQRDLQFFFNFCD 339 +P Y + R LQ F + Sbjct: 457 DPWVYILFRRAVLRRLQPRLEFLE 480 >4N9N-A nrPDB Length = 438 Score = 47.8 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 10/52 (19%), Positives = 19/52 (36%), Gaps = 2/52 (3%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIIL 53 S ++Q N + + + A+ D P A IF + A + + Sbjct: 257 KSRWYNQTPNRAKRVITTFRTGTWDAYV--DSMSPSAWIFHVKGAATILTAV 306 >5B2G-A nrPDB Length = 364 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 8/52 (15%), Positives = 18/52 (34%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIIL 53 S ++Q N + + + A++ M LA+ ++L Sbjct: 141 KSRWYNQTPNRAKRVITTFRTGTWDAYKGMASMGLQVMGIALAVLGWLAVML 192 >5I14-A nrPDB Length = 121 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 5/29 (17%), Positives = 12/29 (41%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A++N Sbjct: 92 KSRWYNQTPNRAKRVITTFRTGTWDAYKN 120 >5EUT-A nrPDB Length = 556 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 5/29 (17%), Positives = 12/29 (41%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A++N Sbjct: 238 KSRWYNQTPNRAKRVITTFRTGTWDAYKN 266 >4WTV-A nrPDB Length = 514 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 5/29 (17%), Positives = 12/29 (41%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A++N Sbjct: 210 KSRWYNQTPNRAKRVITTFRTGTWDAYKN 238 >4TN3-A nrPDB Length = 400 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 5/29 (17%), Positives = 12/29 (41%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A++N Sbjct: 371 KSRWYNQTPNRAKRVITTFRTGTWDAYKN 399 >4EPI-A nrPDB Length = 330 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 5/29 (17%), Positives = 12/29 (41%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A++N Sbjct: 301 KSRWYNQTPNRAKRVITTFRTGTWDAYKN 329 >2O7A-A nrPDB Length = 124 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 5/29 (17%), Positives = 12/29 (41%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A++N Sbjct: 77 KSRWYNQTPNRAKRVITTFRTGTWDAYKN 105 >210L-A nrPDB Length = 163 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 5/29 (17%), Positives = 12/29 (41%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A++N Sbjct: 134 KSRWYNQTPNRAKRVITTFRTGTWDAYKN 162 >1T8A-A nrPDB Length = 175 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 5/29 (17%), Positives = 12/29 (41%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A++N Sbjct: 146 KSRWYNQTPNRAKRVITTFRTGTWDAYKN 174 >192L-A nrPDB Length = 164 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 5/29 (17%), Positives = 12/29 (41%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A++N Sbjct: 135 KSRWYNQTPNRAKRVITTFRTGTWDAYKN 163 >6FW2-A nrPDB Length = 459 Score = 45.5 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 5/30 (16%), Positives = 11/30 (36%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEND 31 S ++Q N + + + A+ D Sbjct: 216 KSRWYNQTPNRAKRVITTFRTGTWDAYTKD 245 >6A9E-A nrPDB Length = 389 Score = 45.1 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 7/51 (13%), Positives = 18/51 (35%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVII 52 S ++Q N + + + A+ + F L G++++ Sbjct: 135 KSRWYNQTPNRAKRVITTFRTGTWDAYAAARTVQRRLLAFALRKLIGSILL 185 >2QB0-B nrPDB Length = 241 Score = 45.1 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 4/28 (14%), Positives = 11/28 (39%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFE 29 S ++Q N + + + A++ Sbjct: 214 KSRWYNQTPNRAKRVITTFRTGTWDAYK 241 >5EWX-A nrPDB Length = 227 Score = 44.7 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 5/29 (17%), Positives = 11/29 (37%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A+ N Sbjct: 198 KSRWYNQTPNRAKRVITTFRTGTWDAYAN 226 >5XF1-A nrPDB Length = 574 Score = 44.7 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 7/48 (14%), Positives = 17/48 (35%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGA 49 S ++Q N + + + A+E L L + + + + Sbjct: 367 KSRWYNQTPNRAKRVITTFRTGTWDAYERSFFSLYLGIGWGAPMLFVV 414 >4IAP-A nrPDB Length = 260 Score = 44.3 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 4/29 (13%), Positives = 11/29 (37%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A+ + Sbjct: 153 KSRWYNQTPNRAKRVITTFRTGTWDAYVD 181 >4YXC-A nrPDB Length = 185 Score = 44.3 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 4/29 (13%), Positives = 10/29 (34%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A+ Sbjct: 156 KSRWYNQTPNRAKRVITTFRTGTWDAYAA 184 >4YX7-C nrPDB Length = 197 Score = 44.3 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 4/29 (13%), Positives = 10/29 (34%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A+ Sbjct: 168 KSRWYNQTPNRAKRVITTFRTGTWDAYAA 196 >5VBA-A nrPDB Length = 437 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 4/28 (14%), Positives = 10/28 (35%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFE 29 S ++Q N + + + A+ Sbjct: 154 KSRWYNQTPNRAKRVITTFRTGTWDAYA 181 >6AJJ-A nrPDB Length = 943 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 5/28 (17%), Positives = 11/28 (39%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFE 29 S ++Q N + + + A+E Sbjct: 897 KSRWYNQTPNRAKRVITTFRTGTWDAYE 924 >5JEA-K nrPDB Length = 279 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 5/29 (17%), Positives = 11/29 (37%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S +Q N + + + A++N Sbjct: 250 KSRWHNQTPNRAKRVITTFRTGTWDAYKN 278 >6D9M-A nrPDB Length = 337 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 4/27 (14%), Positives = 10/27 (37%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAF 28 S ++Q N + + + A+ Sbjct: 135 KSRWYNQTPNRAKRVITTFRTGTWDAY 161 >4XSJ-A nrPDB Length = 262 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 4/27 (14%), Positives = 10/27 (37%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAF 28 S ++Q N + + + A+ Sbjct: 135 KSRWYNQTPNRAKRVITTFRTGTWDAY 161 >5V86-A nrPDB Length = 384 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 5/29 (17%), Positives = 11/29 (37%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + A++N Sbjct: 157 KSRWYNQTPNRTKRVITTFATGTWDAYKN 185 >5YQR-A nrPDB Length = 276 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 4/30 (13%), Positives = 12/30 (40%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEND 31 S ++Q N + + + A+ ++ Sbjct: 136 KSRWYNQTPNRAKRVITTFRTGTWDAYGSE 165 >4EKQ-A nrPDB Length = 187 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 4/29 (13%), Positives = 12/29 (41%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q + + + + A++N Sbjct: 158 KSRWYNQCPDRAKRVITTFRTGTWDAYKN 186 >4HTT-A nrPDB Length = 418 Score = 42.0 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 5/29 (17%), Positives = 12/29 (41%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFEN 30 S ++Q N + + + A++N Sbjct: 379 KSRWYNQTPNRAKRVITTFRTGTWDAYKN 407 >5EE7-A nrPDB Length = 452 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 4/33 (12%), Positives = 10/33 (30%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCH 34 S ++Q N + + + A+ Sbjct: 254 KSRWYNQTPNRAKRVITTFRTGTWDAYPERSFF 286 >5CGD-A nrPDB Length = 444 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 4/28 (14%), Positives = 11/28 (39%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFE 29 S ++Q N + + + A++ Sbjct: 247 KSRWYNQTPNRAKRVITTFRTGTWDAYK 274 >5VEW-A nrPDB Length = 455 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 7/55 (12%), Positives = 18/55 (32%), Gaps = 5/55 (9%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVS 56 S ++Q N + + + A+ +A+ +G ++ V Sbjct: 258 KSRWYNQTPNRAKRVITTFRTGTWDAYSEQ-----WIFRLYVAIGWGVPLLFVVP 307 >2LOT-A nrPDB Length = 64 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 7/28 (25%), Positives = 15/28 (53%) Query: 42 TLALAYGAVIILGVSGNLALIIIILKQK 69 + Y V +LG +GN ++ + ++K Sbjct: 30 LIPAIYMLVFLLGTTGNGLVLWTVFRKK 57 >4K5Y-A nrPDB Length = 441 Score = 38.9 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 4/27 (14%), Positives = 10/27 (37%) Query: 2 NSTLFSQVENHSVHSNFSEKNAQLLAF 28 S ++Q N + + + A+ Sbjct: 252 KSRWYNQTPNRAKRVIATFRTGTWDAY 278 >5NX2-A nrPDB Length = 422 Score = 33.2 bits (74), Expect = 0.21, Method: Composition-based stats. Identities = 41/309 (13%), Positives = 94/309 (30%), Gaps = 43/309 (13%) Query: 36 PLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCL- 94 P + L + Y L S + I+L + + N + +NL S +L A+ Sbjct: 118 PEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFI 177 Query: 95 ---PFTFVYT---LMDHW-----VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLII 143 ++Y+ W C+L + + + L++ V + + Sbjct: 178 KDAALKWMYSEAAQAHQWRGLLSYQDSLSCRLVFLFMQYCVAANYYWLLVEGV--YLYTL 235 Query: 144 NPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP 203 + +++ W + + +P + + C + Sbjct: 236 LAFSVFSEQWIFRLYVSIGWGVPLLFVVP-------------WGIVKYLYEDEAC---WA 279 Query: 204 SDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINI 263 +S+ + + L + + + F+ + K + N+M K + T + Sbjct: 280 RNSNMNYWLIIRLPILFAIGVNFLIFVRVIAIVVSKLKANLMCKTDIKCRLAKSTLTLIA 339 Query: 264 MLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFL 323 +L ++ V FA F ++ + L + I Y F Sbjct: 340 LLATVEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVA-------------ILYCFA 386 Query: 324 NKNFQRDLQ 332 N Q + + Sbjct: 387 NNEVQLEFR 395 >6B3J-R nrPDB Length = 491 Score = 32.0 bits (71), Expect = 0.48, Method: Composition-based stats. Identities = 42/309 (13%), Positives = 99/309 (32%), Gaps = 43/309 (13%) Query: 36 PLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCL- 94 P + L + Y L S + I+L + + N + +NL S +L A+ Sbjct: 146 PEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFI 205 Query: 95 ---PFTFVYTL---MDHW-----VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLII 143 ++Y+ W C+L + + + + L++ V + + Sbjct: 206 KDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGV--YLYTL 263 Query: 144 NPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP 203 + +++ W + + +P+ I + + ++ C + Sbjct: 264 LAFSVFSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEG-------------C---WT 307 Query: 204 SDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINI 263 +S+ + + L + + + F+ + K + N+M K + T + Sbjct: 308 RNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIP 367 Query: 264 MLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFL 323 +L + V FA F ++ + L + I Y F+ Sbjct: 368 LLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVA-------------ILYCFV 414 Query: 324 NKNFQRDLQ 332 N Q + + Sbjct: 415 NNEVQLEFR 423 >5VAI-R nrPDB Length = 461 Score = 31.6 bits (70), Expect = 0.62, Method: Composition-based stats. Identities = 42/309 (13%), Positives = 97/309 (31%), Gaps = 43/309 (13%) Query: 36 PLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCL- 94 P + +L + Y L S + I+L + + N + +NL S +L A+ Sbjct: 176 PEERLLSLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFI 235 Query: 95 ---PFTFVYTL---MDHW-----VFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLII 143 ++Y+ W C+L + + + + L++ + + Sbjct: 236 KDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGA--YLYTL 293 Query: 144 NPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFP 203 R + +++ W + + +P+ I + + ++ C + Sbjct: 294 LAFAVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEG-------------C---WT 337 Query: 204 SDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINI 263 +S+ + + L + + + F+ + K + N+M K + T + Sbjct: 338 RNSNMNYWLIIRLPILFAIGVNFLIFIRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIP 397 Query: 264 MLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFL 323 +L + V FA L F + I Y F+ Sbjct: 398 LLGTHEVIFAF-------VMDEHARGTLRFVKLFTELSFTSFQGLMVA------ILYCFV 444 Query: 324 NKNFQRDLQ 332 N Q + + Sbjct: 445 NNEVQMEFR 453 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.316 0.130 0.372 Lambda K H 0.267 0.0398 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,351,784 Number of Sequences: 36641 Number of extensions: 472664 Number of successful extensions: 2200 Number of sequences better than 10.0: 147 Number of HSP's better than 10.0 without gapping: 221 Number of HSP's successfully gapped in prelim test: 30 Number of HSP's that attempted gapping in prelim test: 1273 Number of HSP's gapped (non-prelim): 420 length of query: 384 length of database: 10,336,785 effective HSP length: 99 effective length of query: 285 effective length of database: 6,709,326 effective search space: 1912157910 effective search space used: 1912157910 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.2 bits) S2: 60 (27.8 bits)