BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P24941 (298 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2BPM-A nrPDB 614 e-176 6GU6-A nrPDB 406 e-114 3NIZ-A nrPDB 380 e-106 1V0B-A nrPDB 371 e-103 4AU8-A nrPDB 356 7e-99 3GC0-A nrPDB 343 7e-95 4KRC-A nrPDB 342 1e-94 5G6V-A nrPDB 325 1e-89 1G3N-A nrPDB 275 2e-74 1UA2-A nrPDB 273 8e-74 2W96-B nrPDB 253 5e-68 5EFQ-A nrPDB 243 7e-65 4NST-A nrPDB 243 9e-65 4BBM-A nrPDB 234 3e-62 4AGU-A nrPDB 231 4e-61 3MIA-A nrPDB 215 2e-56 4ZSG-A nrPDB 212 2e-55 4IC8-A nrPDB 211 3e-55 4BGQ-A nrPDB 204 5e-53 4MYG-A nrPDB 202 1e-52 4QTB-A nrPDB 201 4e-52 3OZ6-A nrPDB 199 2e-51 5Z33-A nrPDB 195 3e-50 3OHT-A nrPDB 194 5e-50 6DTL-A nrPDB 194 5e-50 5NGU-A nrPDB 193 6e-50 1CM8-A nrPDB 193 7e-50 4CRL-A nrPDB 192 1e-49 4EWQ-A nrPDB 191 3e-49 2F9G-A nrPDB 191 3e-49 3ZDU-A nrPDB 191 4e-49 3GC9-A nrPDB 187 4e-48 3RP9-A nrPDB 181 4e-46 4E7W-A nrPDB 177 4e-45 3FI2-A nrPDB 176 8e-45 1JNK-A nrPDB 176 8e-45 5AIR-A nrPDB 175 3e-44 4O2Z-A nrPDB 171 3e-43 3EB0-A nrPDB 171 3e-43 3N9X-A nrPDB 171 4e-43 2XS0-A nrPDB 170 5e-43 3E7O-A nrPDB 169 1e-42 5AWM-A nrPDB 167 6e-42 3NIE-A nrPDB 166 9e-42 3PG1-A nrPDB 166 1e-41 3E3P-A nrPDB 166 1e-41 4QNY-A nrPDB 165 2e-41 2I6L-A nrPDB 164 5e-41 5ZTN-A nrPDB 138 3e-33 5YKS-A nrPDB 137 7e-33 5Y86-A nrPDB 135 3e-32 5XVU-A nrPDB 133 9e-32 3LIJ-A nrPDB 133 1e-31 4MVF-A nrPDB 133 1e-31 6HMD-A nrPDB 132 3e-31 3NCG-A nrPDB 131 4e-31 2PVN-A nrPDB 130 8e-31 3DXN-A nrPDB 129 1e-30 3DFA-A nrPDB 129 1e-30 2WQN-A nrPDB 129 2e-30 3HZT-A nrPDB 129 2e-30 6EII-A nrPDB 128 3e-30 4UZD-A nrPDB 127 5e-30 4MD7-E nrPDB 127 6e-30 6FD3-A nrPDB 124 6e-29 3MA6-A nrPDB 124 6e-29 2QNJ-A nrPDB 123 9e-29 6O6Q-A nrPDB 123 1e-28 5JN2-A nrPDB 123 1e-28 2WO6-A nrPDB 122 1e-28 3D2K-A nrPDB 122 2e-28 5ES1-A nrPDB 122 2e-28 4D28-A nrPDB 122 2e-28 6HXF-B nrPDB 122 3e-28 5KZ7-A nrPDB 121 4e-28 3Q53-A nrPDB 120 7e-28 3MN3-A nrPDB 120 8e-28 6FDY-U nrPDB 119 1e-27 4LG4-A nrPDB 118 2e-27 2HAK-A nrPDB 118 2e-27 5XZW-A nrPDB 118 3e-27 4APC-A nrPDB 118 3e-27 6AO5-A nrPDB 118 4e-27 3COM-A nrPDB 117 6e-27 6C9D-A nrPDB 117 8e-27 4LFI-A nrPDB 116 9e-27 4YNZ-A nrPDB 115 2e-26 5FG8-A nrPDB 115 3e-26 4B8L-A nrPDB 115 3e-26 4IAN-A nrPDB 114 4e-26 6CQF-A nrPDB 114 4e-26 2UV2-A nrPDB 114 7e-26 4PDS-A nrPDB 113 1e-25 2F57-A nrPDB 112 1e-25 4CQG-A nrPDB 112 2e-25 4RED-A nrPDB 112 2e-25 4JXF-A nrPDB 111 3e-25 6CMJ-A nrPDB 111 3e-25 4REW-A nrPDB 111 4e-25 2WTK-C nrPDB 111 4e-25 3Q5I-A nrPDB 111 5e-25 3TXO-A nrPDB 110 5e-25 4D2V-A nrPDB 110 5e-25 4KS7-A nrPDB 110 6e-25 4CFH-A nrPDB 110 7e-25 3H4J-B nrPDB 110 8e-25 2BRG-A nrPDB 110 8e-25 4CFF-A nrPDB 110 9e-25 5EZV-A nrPDB 110 1e-24 4RGJ-A nrPDB 109 1e-24 4CZT-A nrPDB 109 2e-24 2XNP-A nrPDB 108 3e-24 5F9E-A nrPDB 108 3e-24 2YZA-A nrPDB 107 4e-24 5J5T-A nrPDB 107 5e-24 4RLP-A nrPDB 107 5e-24 5KKR-C nrPDB 107 5e-24 3EQC-A nrPDB 107 6e-24 4AN9-A nrPDB 107 6e-24 4L42-A nrPDB 107 6e-24 1U5R-A nrPDB 106 9e-24 2GCD-A nrPDB 106 1e-23 3TAC-A nrPDB 106 1e-23 2Q0N-A nrPDB 106 1e-23 4XBR-A nrPDB 106 1e-23 4JDH-A nrPDB 106 2e-23 3KK8-A nrPDB 105 2e-23 4FIE-A nrPDB 105 3e-23 5YV8-A nrPDB 104 4e-23 3RAW-A nrPDB 104 4e-23 2BDW-A nrPDB 104 5e-23 1S9I-A nrPDB 103 6e-23 5X8I-B nrPDB 103 7e-23 2VZ6-A nrPDB 103 1e-22 3BHH-A nrPDB 103 1e-22 5UNP-A nrPDB 102 1e-22 2V7O-A nrPDB 102 1e-22 5U6Y-A nrPDB 102 2e-22 2Y7J-A nrPDB 102 2e-22 4EQM-A nrPDB 102 2e-22 4WNO-A nrPDB 102 2e-22 3IS5-A nrPDB 101 3e-22 2VN9-A nrPDB 101 4e-22 5WAX-A nrPDB 101 5e-22 4AF3-A nrPDB 100 6e-22 3SOA-A nrPDB 100 6e-22 1KOA-A nrPDB 100 7e-22 3UTO-A nrPDB 100 8e-22 4YZB-A nrPDB 100 8e-22 2Z7Q-A nrPDB 100 9e-22 6E2O-A nrPDB 100 9e-22 2X4F-A nrPDB 100 1e-21 5HVK-A nrPDB 99 2e-21 2XIK-A nrPDB 99 2e-21 1ZXE-A nrPDB 99 2e-21 5JZN-A nrPDB 99 2e-21 4QMW-A nrPDB 99 2e-21 5IG1-A nrPDB 99 3e-21 3UDB-A nrPDB 99 3e-21 4FG9-A nrPDB 98 4e-21 3ZUT-A nrPDB 98 4e-21 2JD5-A nrPDB 98 4e-21 4TPT-A nrPDB 98 6e-21 1KOB-A nrPDB 97 6e-21 1PHK-A nrPDB 97 9e-21 5D9K-A nrPDB 97 1e-20 5FET-A nrPDB 96 1e-20 2JC6-A nrPDB 96 1e-20 6QAU-A nrPDB 96 2e-20 2YCR-A nrPDB 96 2e-20 2JAM-A nrPDB 96 2e-20 6DBN-A nrPDB 96 3e-20 2RIO-A nrPDB 95 3e-20 4M7I-A nrPDB 95 4e-20 3UC3-A nrPDB 95 4e-20 2W1I-A nrPDB 94 5e-20 3NYO-A nrPDB 94 5e-20 3IO7-A nrPDB 94 6e-20 3I6U-A nrPDB 94 8e-20 5VD3-A nrPDB 94 8e-20 2W4O-A nrPDB 94 8e-20 5DYK-A nrPDB 94 1e-19 6CCF-A nrPDB 93 1e-19 3HKO-A nrPDB 93 1e-19 2J90-A nrPDB 93 1e-19 3VN9-A nrPDB 93 1e-19 6FYV-A nrPDB 92 2e-19 3KN6-A nrPDB 92 2e-19 4WB7-A nrPDB 92 2e-19 5LOH-A nrPDB 92 2e-19 3A8W-A nrPDB 92 4e-19 5D7A-A nrPDB 91 5e-19 2JDO-A nrPDB 91 5e-19 1FOT-A nrPDB 91 5e-19 4CSV-A nrPDB 91 5e-19 5X3F-B nrPDB 91 7e-19 3DAK-A nrPDB 91 7e-19 5DBX-A nrPDB 91 7e-19 5N23-A nrPDB 91 8e-19 3FME-A nrPDB 91 8e-19 3A4O-X nrPDB 90 9e-19 4JG6-A nrPDB 90 9e-19 6HV0-A nrPDB 90 1e-18 4FZF-B nrPDB 90 1e-18 4TNB-A nrPDB 90 1e-18 3F3Z-A nrPDB 90 1e-18 4RA4-A nrPDB 89 2e-18 4OLI-A nrPDB 89 2e-18 3ORZ-A nrPDB 89 2e-18 3QA8-A nrPDB 89 3e-18 4E20-A nrPDB 89 3e-18 4GS6-A nrPDB 89 3e-18 6DBM-A nrPDB 88 4e-18 3GUB-A nrPDB 88 4e-18 4NIF-A nrPDB 88 5e-18 2I0E-A nrPDB 88 5e-18 3PFQ-A nrPDB 88 6e-18 1AD5-A nrPDB 87 7e-18 3DB8-A nrPDB 87 8e-18 6CTH-A nrPDB 87 8e-18 3ORP-A nrPDB 87 8e-18 2HK5-A nrPDB 87 9e-18 3ALO-A nrPDB 87 9e-18 3HMP-A nrPDB 87 1e-17 5AP3-A nrPDB 87 1e-17 6GVJ-A nrPDB 87 1e-17 5H2U-A nrPDB 86 2e-17 4KIK-B nrPDB 86 2e-17 5UIU-A nrPDB 86 2e-17 6NPU-A nrPDB 86 2e-17 4B6L-A nrPDB 86 2e-17 4XEY-B nrPDB 86 2e-17 1VZO-A nrPDB 86 2e-17 4U41-A nrPDB 86 3e-17 4E93-A nrPDB 86 3e-17 4PL5-B nrPDB 86 3e-17 5TOS-A nrPDB 86 3e-17 2YAB-A nrPDB 85 3e-17 4XCU-A nrPDB 85 4e-17 2DQ7-X nrPDB 85 4e-17 6E9W-A nrPDB 85 4e-17 4C0T-A nrPDB 85 5e-17 3MV5-A nrPDB 84 6e-17 4UYA-A nrPDB 84 6e-17 5KCV-A nrPDB 84 7e-17 2ZMD-A nrPDB 84 7e-17 2FO0-A nrPDB 84 7e-17 4YHJ-A nrPDB 84 7e-17 4I6B-A nrPDB 84 8e-17 3PLS-A nrPDB 83 1e-16 3DLS-A nrPDB 83 1e-16 2H8H-A nrPDB 83 1e-16 6F3F-A nrPDB 83 2e-16 2A1A-B nrPDB 83 2e-16 6ED6-A nrPDB 82 2e-16 2PL0-A nrPDB 82 2e-16 5B2L-A nrPDB 82 2e-16 6FER-A nrPDB 82 3e-16 1ZWS-A nrPDB 82 3e-16 4WUA-A nrPDB 82 3e-16 5VO2-A nrPDB 82 3e-16 2A27-A nrPDB 82 3e-16 5TQX-A nrPDB 82 3e-16 3HDN-A nrPDB 82 4e-16 3UIU-A nrPDB 82 4e-16 6FEX-A nrPDB 81 5e-16 5SYS-A nrPDB 81 5e-16 3SXS-A nrPDB 81 6e-16 2PSQ-A nrPDB 80 7e-16 4OTD-A nrPDB 80 8e-16 5UUU-A nrPDB 80 8e-16 5EG3-A nrPDB 80 8e-16 2X7G-A nrPDB 80 8e-16 3PVW-A nrPDB 80 9e-16 2XYN-A nrPDB 80 1e-15 4PWN-A nrPDB 80 1e-15 1LUF-A nrPDB 80 1e-15 4FR4-A nrPDB 80 1e-15 4EBW-A nrPDB 80 1e-15 2J0K-A nrPDB 80 1e-15 4CRS-A nrPDB 79 2e-15 3LM0-A nrPDB 79 2e-15 5U6B-A nrPDB 79 2e-15 5TUR-A nrPDB 79 2e-15 4RC3-A nrPDB 79 2e-15 3BGP-A nrPDB 79 2e-15 5MJB-A nrPDB 79 2e-15 1U54-B nrPDB 79 3e-15 4HZS-A nrPDB 79 3e-15 4G3E-A nrPDB 78 4e-15 3PPZ-A nrPDB 78 4e-15 5A46-A nrPDB 78 5e-15 5O2B-A nrPDB 78 5e-15 1TKI-A nrPDB 78 5e-15 6BSD-A nrPDB 78 5e-15 4AT3-A nrPDB 78 5e-15 5O2C-A nrPDB 78 5e-15 3GQL-A nrPDB 78 5e-15 3TT0-A nrPDB 78 5e-15 3QD2-B nrPDB 77 7e-15 3ZZW-A nrPDB 77 7e-15 4IDT-A nrPDB 77 8e-15 3C51-A nrPDB 77 8e-15 4UY9-A nrPDB 77 1e-14 4K33-A nrPDB 77 1e-14 1U59-A nrPDB 77 1e-14 4OW8-A nrPDB 76 1e-14 5AMN-A nrPDB 76 1e-14 4YFF-A nrPDB 76 1e-14 3DTC-A nrPDB 76 2e-14 4X3F-A nrPDB 76 2e-14 4HVI-A nrPDB 76 2e-14 6B2Q-A nrPDB 76 2e-14 5X5O-A nrPDB 76 2e-14 2R2P-A nrPDB 75 2e-14 6J5U-C nrPDB 75 3e-14 3DKO-A nrPDB 75 3e-14 3QGY-A nrPDB 75 3e-14 2HW6-A nrPDB 75 3e-14 4C59-A nrPDB 75 4e-14 6BDL-A nrPDB 75 4e-14 2OZO-A nrPDB 75 4e-14 3C1X-A nrPDB 75 4e-14 3V5Q-A nrPDB 75 5e-14 5HLW-A nrPDB 75 5e-14 4X7Q-B nrPDB 75 5e-14 2VD5-A nrPDB 74 6e-14 4M66-A nrPDB 74 8e-14 4NEU-A nrPDB 74 8e-14 5L6P-A nrPDB 74 8e-14 2OU7-A nrPDB 74 8e-14 1FVR-A nrPDB 74 1e-13 4XLV-A nrPDB 74 1e-13 4PDO-A nrPDB 74 1e-13 4J52-A nrPDB 73 1e-13 1BYG-A nrPDB 73 2e-13 5KMM-A nrPDB 72 2e-13 5IKW-A nrPDB 72 2e-13 1K9A-A nrPDB 72 2e-13 1JPA-A nrPDB 72 2e-13 3BBT-B nrPDB 72 3e-13 4P5Q-A nrPDB 72 3e-13 6BXI-A nrPDB 72 3e-13 5GNK-A nrPDB 72 4e-13 3LZB-A nrPDB 71 5e-13 4XI2-A nrPDB 71 5e-13 3TKU-A nrPDB 71 5e-13 2Y6O-A nrPDB 71 5e-13 5O0Y-A nrPDB 71 6e-13 6CKI-A nrPDB 71 6e-13 5FM2-A nrPDB 71 6e-13 5U6C-A nrPDB 71 7e-13 4F9B-A nrPDB 71 7e-13 2VWV-A nrPDB 70 9e-13 4H1J-A nrPDB 70 1e-12 2PMN-X nrPDB 70 1e-12 3KA0-A nrPDB 70 1e-12 6E4F-A nrPDB 69 2e-12 3LLT-A nrPDB 69 2e-12 3QUP-A nrPDB 69 2e-12 1NY3-A nrPDB 69 2e-12 4AW2-A nrPDB 69 2e-12 2OZA-A nrPDB 69 3e-12 2BUJ-A nrPDB 69 3e-12 4Y93-A nrPDB 69 3e-12 3G2F-A nrPDB 68 6e-12 3FXW-A nrPDB 67 9e-12 4LRM-A nrPDB 67 9e-12 3UIM-A nrPDB 67 1e-11 3OMV-A nrPDB 67 1e-11 5TE0-A nrPDB 67 1e-11 3KUL-B nrPDB 66 2e-11 4Y83-A nrPDB 65 3e-11 2QKW-B nrPDB 65 3e-11 3ZBF-A nrPDB 65 3e-11 5LPZ-A nrPDB 65 3e-11 6BFN-A nrPDB 65 3e-11 5LPV-A nrPDB 65 3e-11 3I81-A nrPDB 65 3e-11 2H34-A nrPDB 65 3e-11 3CJF-A nrPDB 65 4e-11 5HI2-A nrPDB 65 4e-11 2OGV-A nrPDB 64 7e-11 3HNG-A nrPDB 64 9e-11 3MDY-A nrPDB 64 1e-10 5GRN-A nrPDB 64 1e-10 1PY5-A nrPDB 63 1e-10 4EUU-A nrPDB 63 1e-10 4JLC-A nrPDB 63 1e-10 5C26-A nrPDB 63 1e-10 4EUT-A nrPDB 63 1e-10 4LQP-A nrPDB 63 2e-10 6O8B-A nrPDB 62 2e-10 4F0G-A nrPDB 62 2e-10 4FL3-A nrPDB 62 2e-10 6NT9-A nrPDB 62 2e-10 6GQK-A nrPDB 62 3e-10 5HIE-A nrPDB 61 5e-10 2WTK-B nrPDB 61 5e-10 5VDK-A nrPDB 61 5e-10 5XD6-A nrPDB 61 5e-10 3G0E-A nrPDB 61 5e-10 4XUF-A nrPDB 61 6e-10 5X02-A nrPDB 61 7e-10 3Q4U-A nrPDB 60 8e-10 3VHK-A nrPDB 60 9e-10 3PP0-A nrPDB 60 1e-09 3BEA-A nrPDB 59 3e-09 4Y12-A nrPDB 59 4e-09 3KRL-A nrPDB 58 5e-09 2PZI-A nrPDB 58 5e-09 2QLU-A nrPDB 57 7e-09 3SOC-A nrPDB 57 8e-09 5WNO-A nrPDB 57 8e-09 5CEK-A nrPDB 57 8e-09 6DC0-A nrPDB 57 1e-08 2Y4I-B nrPDB 57 1e-08 4NFN-A nrPDB 56 2e-08 5WNL-A nrPDB 56 2e-08 4BTK-A nrPDB 56 2e-08 2CHL-A nrPDB 55 4e-08 2C47-A nrPDB 55 4e-08 4R7H-A nrPDB 55 4e-08 3M42-A nrPDB 52 2e-07 3LMG-A nrPDB 52 3e-07 5VC6-A nrPDB 52 3e-07 5X1R-A nrPDB 52 4e-07 5X18-A nrPDB 51 7e-07 2CMW-A nrPDB 50 1e-06 5AR8-A nrPDB 50 1e-06 4NT4-A nrPDB 49 2e-06 5E8V-A nrPDB 49 2e-06 3SV0-A nrPDB 49 2e-06 4RT7-A nrPDB 49 3e-06 3AOX-A nrPDB 48 4e-06 3MY0-A nrPDB 48 4e-06 4L00-A nrPDB 48 5e-06 5M07-A nrPDB 47 1e-05 4XHH-A nrPDB 45 3e-05 4XHL-A nrPDB 45 5e-05 5FQD-C nrPDB 45 5e-05 1CSN-A nrPDB 43 1e-04 4TN6-A nrPDB 43 2e-04 4M69-B nrPDB 42 3e-04 4IX6-A nrPDB 42 4e-04 4BTF-A nrPDB 42 5e-04 5OAT-A nrPDB 41 6e-04 4JRN-A nrPDB 40 0.001 5J0A-A nrPDB 40 0.002 5L2Q-C nrPDB 39 0.003 3REP-A nrPDB 39 0.004 4L68-A nrPDB 38 0.004 4MWI-A nrPDB 38 0.005 2RSV-A nrPDB 37 0.007 2LAV-A nrPDB 37 0.010 5UU1-A nrPDB 35 0.038 4OAU-C nrPDB 35 0.044 4O1O-A nrPDB 34 0.065 6G4J-A nrPDB 34 0.093 5UV4-A nrPDB 33 0.13 5C01-A nrPDB 33 0.16 4WOV-A nrPDB 33 0.19 4CYJ-A nrPDB 33 0.22 5CLR-A nrPDB 32 0.26 6J6I-B nrPDB 32 0.28 5KH2-A nrPDB 30 1.7 6EQI-C nrPDB 30 1.8 4BWP-A nrPDB 29 2.3 5VE6-A nrPDB 29 2.4 6EWX-A nrPDB 29 2.7 4AZV-A nrPDB 29 2.8 5ZBY-A nrPDB 28 3.6 1T6J-A nrPDB 28 3.7 4AZW-A nrPDB 28 4.0 >2BPM-A nrPDB Length = 309 Score = 614 bits (1583), Expect = e-176, Method: Compositional matrix adjust. Identities = 298/298 (100%), Positives = 298/298 (100%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH Sbjct: 6 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 65 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS Sbjct: 66 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 125 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY Sbjct: 126 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 185 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF Sbjct: 186 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 245 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL Sbjct: 246 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 303 >6GU6-A nrPDB Length = 302 Score = 406 bits (1044), Expect = e-114, Method: Compositional matrix adjust. Identities = 196/302 (64%), Positives = 236/302 (78%), Gaps = 11/302 (3%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME++ K+EKIGEGTYGVVYK R+K TG+VVA+KKIRL++E EGVPSTAIREISLLKEL H Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 65 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIP------LPLIKSYLFQLLQG 114 PNIV L DV+ +++LYL+FEFL DLKK++D+ IP L+KSYL+Q+LQG Sbjct: 66 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDS-----IPPGQYMDSSLVKSYLYQILQG 120 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 + FCHS RVLHRDLKPQNLLI+ +G IKLADFGLARAFG+P+R YTHEVVTLWYR+PE+L Sbjct: 121 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 180 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 LG YST VDIWS+G IFAE+ T++ LF GDSEIDQLFRIFR LGTP+ VWP V S+ Sbjct: 181 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 240 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 DYK +FPKW + V LDE+G LLS+ML YDP KRIS K AL HP+F D+ + Sbjct: 241 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIK 300 Query: 295 HL 296 + Sbjct: 301 KM 302 >3NIZ-A nrPDB Length = 311 Score = 380 bits (975), Expect = e-106, Method: Compositional matrix adjust. Identities = 182/290 (62%), Positives = 235/290 (81%), Gaps = 3/290 (1%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME +QK+EK+GEGTYGVVYKA++ G +VALK+IRLD E EG+PSTAIREISLLKEL+H Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDS-QGRIVALKRIRLDAEDEGIPSTAIREISLLKELHH 78 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 PNIV L+DVIH+E L LVFEF+ +DLKK +D + TG+ IK YL+QLL+G+A CH Sbjct: 79 PNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENK-TGLQDSQIKIYLYQLLRGVAHCHQ 137 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 HR+LHRDLKPQNLLIN++GA+KLADFGLARAFG+PVR+YTHEVVTLWYRAP++L+G K Y Sbjct: 138 HRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKKY 197 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239 ST+VDIWS+GCIFAEM+T + LFPG ++ DQL +IF LGTP+ WP V +P +K + Sbjct: 198 STSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQRT 257 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 F + ++ +S ++P ++G LLS ML +DPNKRISA+ A+ HP+F+D+ Sbjct: 258 FQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDL 307 >1V0B-A nrPDB Length = 288 Score = 371 bits (952), Expect = e-103, Method: Compositional matrix adjust. Identities = 182/288 (63%), Positives = 215/288 (74%), Gaps = 2/288 (0%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME + +EKIGEGTYGVVYKA+N GE ALKKIRL+ E EG+PST IREIS+LKEL H Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NIVKL DVIHT+ +L LVFE L QDLKK +D G+ KS+L QLL G+A+CH Sbjct: 60 SNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCE-GGLESVTAKSFLLQLLNGIAYCHD 118 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 RVLHRDLKPQNLLIN EG +K+ADFGLARAFG+PVR YTHEVVTLWYRAP++L+G K Y Sbjct: 119 RRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKY 178 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 ST +DIWS+GCIFAEMV LFPG SE DQL RIFR LGTP+ WP VT +P Y P+F Sbjct: 179 STTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNF 238 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + + + LDE G LLS+ML DPN+RI+AK AL H +F++ Sbjct: 239 TVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >4AU8-A nrPDB Length = 296 Score = 356 bits (913), Expect = 7e-99, Method: Compositional matrix adjust. Identities = 175/293 (59%), Positives = 218/293 (74%), Gaps = 4/293 (1%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++K+EKIGEGTYG V+KA+N+ T E+VALK++RLD + EGVPS+A+REI LLKEL H Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 65 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L DV+H++ KL LVFEF QDLKK+ D+ P ++KS+LFQLL+GL FCHS Sbjct: 66 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDP-EIVKSFLFQLLKGLGFCHSR 124 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 VLHRDLKPQNLLIN G +KLADFGLARAFG+PVR Y+ EVVTLWYR P++L G K YS Sbjct: 125 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 184 Query: 182 TAVDIWSLGCIFAEMVTR-RALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 T++D+WS GCIFAE+ R LFPG+ DQL RIFR LGTP E WP +T +PDYKP + Sbjct: 185 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP-Y 243 Query: 241 PKW-ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 P + A VVP L+ GR LL +L +P +RISA+ AL HP+F D P Sbjct: 244 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >3GC0-A nrPDB Length = 329 Score = 343 bits (879), Expect = 7e-95, Method: Compositional matrix adjust. Identities = 166/293 (56%), Positives = 224/293 (76%), Gaps = 8/293 (2%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ ++++ K+GEGTYG VYKA + +T E VA+K+IRL+ E EGVP TAIRE+SLLKEL H Sbjct: 33 IDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQH 92 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NI++L VIH ++L+L+FE+ DLKK+MD + + + +IKS+L+QL+ G+ FCHS Sbjct: 93 RNIIELKSVIHHNHRLHLIFEYAENDLKKYMDKNP--DVSMRVIKSFLYQLINGVNFCHS 150 Query: 121 HRVLHRDLKPQNLLINTEGA-----IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 R LHRDLKPQNLL++ A +K+ DFGLARAFG+P+R +THE++TLWYR PEILL Sbjct: 151 RRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILL 210 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 G ++YST+VDIWS+ CI+AEM+ + LFPGDSEIDQLF+IF LG PD+ WPGVT++PD Sbjct: 211 GSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALPD 270 Query: 236 YKPSFPKWARQDFSKVV-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 +K SFPK+ + +V+ LD++G LL+ ML DP KRISAK AL HP+F Sbjct: 271 WKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFS 323 >4KRC-A nrPDB Length = 317 Score = 342 bits (877), Expect = 1e-94, Method: Compositional matrix adjust. Identities = 165/294 (56%), Positives = 217/294 (73%), Gaps = 10/294 (3%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 F+++EK+G GTY VYK NK TG VALK+++LD+E EG PSTAIREISL+KEL H NI Sbjct: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHENI 65 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALT----GIPLPLIKSYLFQLLQGLAFCH 119 V+L DVIHTENKL LVFEF+ DLKK+MD+ + G+ L L+K + +QLLQGLAFCH Sbjct: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 +++LHRDLKPQNLLIN G +KL DFGLARAFG+PV T++ EVVTLWYRAP++L+G + Sbjct: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 YST++DIWS GCI AEM+T + LFPG ++ +QL IF +GTP+E +WP VT +P Y P+ Sbjct: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 Query: 240 FPKWARQDFSKVV-----PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + +D +V+ PLD + L +L +P+ R+SAK AL HP+F + Sbjct: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 >5G6V-A nrPDB Length = 324 Score = 325 bits (833), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 160/287 (55%), Positives = 207/287 (72%), Gaps = 3/287 (1%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME + K++K+GEGTY VYK ++KLT +VALK+IRL+ E EG P TAIRE+SLLK+L H Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 59 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NIV L D+IHTE L LVFE+L +DLK+++D I + +K +LFQLL+GLA+CH Sbjct: 60 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCG-NIINMHNVKLFLFQLLRGLAYCHR 118 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 +VLHRDLKPQNLLIN G +KLADFGLARA +P +TY +EVVTLWYR P+ILLG Y Sbjct: 119 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDY 178 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239 ST +D+W +GCIF EM T R LFPG + +QL IFR LGTP E WPG+ S ++K + Sbjct: 179 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 238 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 +PK+ + P LD DG LL+++L ++ RISA+ A+ HPFF Sbjct: 239 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >1G3N-A nrPDB Length = 326 Score = 275 bits (702), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 145/299 (48%), Positives = 198/299 (66%), Gaps = 13/299 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARN-KLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59 + ++ V +IGEG YG V+KAR+ K G VALK++R+ T EG+P + IRE+++L+ L Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 60 --HPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112 HPN+V+L DV E KL LVFE + QDL ++D G+P IK +FQLL Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 +GL F HSHRV+HRDLKPQN+L+ + G IKLADFGLAR + + T VVTLWYRAPE Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPE 189 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 +LL Y+T VD+WS+GCIFAEM R+ LF G S++DQL +I +G P E WP + Sbjct: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 +P + +F + Q K V +DE G+ LL + L ++P KRISA +AL+HP+FQD+ + Sbjct: 249 LP--RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 >1UA2-A nrPDB Length = 346 Score = 273 bits (697), Expect = 8e-74, Method: Compositional matrix adjust. Identities = 134/300 (44%), Positives = 194/300 (64%), Gaps = 5/300 (1%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE---GVPSTAIREISLLKEL 58 + ++K++ +GEG + VYKAR+K T ++VA+KKI+L +E G+ TA+REI LL+EL Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 +HPNI+ LLD ++ + LVF+F+ DL+ + ++L P IK+Y+ LQGL + Sbjct: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTP-SHIKAYMLMTLQGLEYL 128 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 H H +LHRDLKP NLL++ G +KLADFGLA++FG P R YTH+VVT WYRAPE+L G + Sbjct: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y VD+W++GCI AE++ R PGDS++DQL RIF TLGTP E WP + S+PDY Sbjct: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV- 247 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298 +F + + +D L+ + ++P RI+A AL +F + P P +L Sbjct: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQL 307 >2W96-B nrPDB Length = 306 Score = 253 bits (647), Expect = 5e-68, Method: Compositional matrix adjust. Identities = 134/292 (45%), Positives = 189/292 (64%), Gaps = 12/292 (4%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN---H 60 ++ V +IG G YG VYKAR+ +G VALK +R+ EG+P + +RE++LL+ L H Sbjct: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEH 65 Query: 61 PNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 PN+V+L+DV T E K+ LVFE + QDL+ ++D + G+P IK + Q L+GL Sbjct: 66 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 125 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 F H++ ++HRDLKP+N+L+ + G +KLADFGLAR + + VVTLWYRAPE+LL Sbjct: 126 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALDPVVVTLWYRAPEVLL 184 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 Y+T VD+WS+GCIFAEM R+ LF G+SE DQL +IF +G P E WP S+P Sbjct: 185 QST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP- 242 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 + +FP + VVP ++E G LL +ML ++P+KRISA AL H + Sbjct: 243 -RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 293 >5EFQ-A nrPDB Length = 347 Score = 243 bits (620), Expect = 7e-65, Method: Compositional matrix adjust. Identities = 134/305 (43%), Positives = 184/305 (60%), Gaps = 21/305 (6%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ F + IGEGTYG VYKAR+K TGE+VALKK+RLD E EG P TAIREI +L++L H Sbjct: 10 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 69 Query: 61 PNIVKL----------LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ 110 +I+ + LD + YLVFE++ DL ++ S L IKS++ Q Sbjct: 70 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLE-SGLVHFNENHIKSFMRQ 128 Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP-VRTYTHEVVTLWYR 169 L++GL +CH LHRD+K N+L+N G IKLADFGLAR + R YT++V+TLWYR Sbjct: 129 LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 188 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 PE+LLG + Y+ A+D+WS GCI E+ T++ +F + E+ QL I R G+P VWP Sbjct: 189 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPD 248 Query: 230 VTSMPDYKPSFPKWA-----RQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284 V +P + PK R++F +P D L ML DP+KR +A+ AL Sbjct: 249 VIKLPYFNTMKPKKQYRRKLREEFV-FIPAAALD---LFDYMLALDPSKRCTAEQALQCE 304 Query: 285 FFQDV 289 F +DV Sbjct: 305 FLRDV 309 >4NST-A nrPDB Length = 351 Score = 243 bits (619), Expect = 9e-65, Method: Compositional matrix adjust. Identities = 134/305 (43%), Positives = 185/305 (60%), Gaps = 21/305 (6%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ F + IGEGTYG VYKA++K TGE+VALKK+RLD E EG P TAIREI +L++L H Sbjct: 12 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 71 Query: 61 PNIVKL----------LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ 110 ++V + LD + YLVFE++ DL ++ S L IKS++ Q Sbjct: 72 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLE-SGLVHFSEDHIKSFMKQ 130 Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP-VRTYTHEVVTLWYR 169 L++GL +CH LHRD+K N+L+N G IKLADFGLAR + R YT++V+TLWYR Sbjct: 131 LMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYR 190 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 PE+LLG + Y+ A+D+WS GCI E+ T++ +F + E+ QL I R G+P VWP Sbjct: 191 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPD 250 Query: 230 VTSMPDYKPSFPKWA-----RQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284 V +P + PK R++FS +P D LL ML DP+KR +A+ L Sbjct: 251 VIKLPYFNTMKPKKQYRRRLREEFS-FIPSAALD---LLDHMLTLDPSKRCTAEQTLQSD 306 Query: 285 FFQDV 289 F +DV Sbjct: 307 FLKDV 311 >4BBM-A nrPDB Length = 331 Score = 234 bits (598), Expect = 3e-62, Method: Compositional matrix adjust. Identities = 121/295 (41%), Positives = 170/295 (57%), Gaps = 15/295 (5%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME ++ + +GEG+YG+V K RNK TG +VA+KK + + V A+REI LLK+L H Sbjct: 24 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 83 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASAL--TGIPLPLIKSYLFQLLQGLAFC 118 N+V LL+V + + YLVFEF+ + +D L G+ +++ YLFQ++ G+ FC Sbjct: 84 ENLVNLLEVCKKKKRWYLVFEFVDHTI---LDDLELFPNGLDYQVVQKYLFQIINGIGFC 140 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 HSH ++HRD+KP+N+L++ G +KL DFG AR P Y EV T WYRAPE+L+G Sbjct: 141 HSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDV 200 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y AVD+W++GC+ EM LFPGDS+IDQL+ I LG + P + + P Sbjct: 201 KYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGN----LIPRHQELFNKNP 256 Query: 239 SFPKW------ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 F R+ + P L E L + LH DP+KR L H FFQ Sbjct: 257 VFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >4AGU-A nrPDB Length = 311 Score = 231 bits (588), Expect = 4e-61, Method: Compositional matrix adjust. Identities = 121/303 (39%), Positives = 177/303 (58%), Gaps = 27/303 (8%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME ++K+ KIGEG+YGVV+K RN+ TG++VA+KK + + A+REI +LK+L H Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 PN+V LL+V + +L+LVFE+ + +D G+P L+KS +Q LQ + FCH Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQ-RGVPEHLVKSITWQTLQAVNFCHK 120 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 H +HRD+KP+N+LI IKL DFG AR P Y EV T WYR+PE+L+G Y Sbjct: 121 HNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQY 180 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VD+W++GC+FAE+++ L+PG S++DQL+ I +TLG +P ++ F Sbjct: 181 GPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLG----------DLIPRHQQVF 230 Query: 241 PKWARQDFSKVVPPLDED--------------GRSLLSQMLHYDPNKRISAKAALAHPFF 286 Q FS V P ED LL LH DP +R++ + L HP+F Sbjct: 231 S--TNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYF 288 Query: 287 QDV 289 +++ Sbjct: 289 ENI 291 >3MIA-A nrPDB Length = 351 Score = 215 bits (548), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 122/309 (39%), Positives = 180/309 (58%), Gaps = 18/309 (5%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 + ++K+ KIG+GT+G V+KAR++ TG+ VALKK+ ++ E EG P TA+REI +L+ L H Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 Query: 61 PNIVKLLDVIHT--------ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112 N+V L+++ T + +YLVF+F DL + ++ L L IK + LL Sbjct: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL-SNVLVKFTLSEIKRVMQMLL 134 Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT----YTHEVVTLWY 168 GL + H +++LHRD+K N+LI +G +KLADFGLARAF + + YT+ VVTLWY Sbjct: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228 R PE+LLG + Y +D+W GCI AEM TR + G++E QL I + G+ VWP Sbjct: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 Query: 229 GVTSMPDY-KPSFPKWARQDFSKVVPPLDED--GRSLLSQMLHYDPNKRISAKAALAHPF 285 V + Y K K ++ + D L+ ++L DP +RI + AL H F Sbjct: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 Query: 286 FQDVTKPVP 294 F + P+P Sbjct: 315 FW--SDPMP 321 >4ZSG-A nrPDB Length = 347 Score = 212 bits (540), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 118/305 (38%), Positives = 168/305 (55%), Gaps = 18/305 (5%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ +E IG G YGVV AR +LTG+ VA+KKI + +RE+ +LK H Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 66 Query: 62 NIVKLLDVIHTE------NKLYLVFEFLHQDLKKFMDASALTGIPLPL--IKSYLFQLLQ 113 NI+ + D++ +Y+V + + DL + + +S PL L ++ +L+QLL+ Sbjct: 67 NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQ----PLTLEHVRYFLYQLLR 122 Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----THEVVTLWYR 169 GL + HS +V+HRDLKP NLL+N +K+ DFG+AR + T V T WYR Sbjct: 123 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 182 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP- 228 APE++L Y+ A+D+WS+GCIF EM+ RR LFPG + + QL I LGTP V Sbjct: 183 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 242 Query: 229 -GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 G + Y S P + V P D SLL +ML ++P+ RISA AAL HPF Sbjct: 243 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 302 Query: 288 DVTKP 292 P Sbjct: 303 KYHDP 307 >4IC8-A nrPDB Length = 442 Score = 211 bits (537), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 118/305 (38%), Positives = 168/305 (55%), Gaps = 18/305 (5%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ +E IG G YGVV AR +LTG+ VA+KKI + +RE+ +LK H Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 114 Query: 62 NIVKLLDVIHTE------NKLYLVFEFLHQDLKKFMDASALTGIPLPL--IKSYLFQLLQ 113 NI+ + D++ +Y+V + + DL + + +S PL L ++ +L+QLL+ Sbjct: 115 NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQ----PLTLEHVRYFLYQLLR 170 Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----THEVVTLWYR 169 GL + HS +V+HRDLKP NLL+N +K+ DFG+AR + T V T WYR Sbjct: 171 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 230 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP- 228 APE++L Y+ A+D+WS+GCIF EM+ RR LFPG + + QL I LGTP V Sbjct: 231 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 290 Query: 229 -GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 G + Y S P + V P D SLL +ML ++P+ RISA AAL HPF Sbjct: 291 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 350 Query: 288 DVTKP 292 P Sbjct: 351 KYHDP 355 >4BGQ-A nrPDB Length = 304 Score = 204 bits (518), Expect = 5e-53, Method: Compositional matrix adjust. Identities = 114/298 (38%), Positives = 166/298 (55%), Gaps = 20/298 (6%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 M F+ + +GEG YGVV K R+K T E+VA+KK + E E V T +RE+ +L+ L Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NIV+L + KLYLVFE++ +++ + ++ G+P +KSY++QL++ + +CH Sbjct: 71 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAIHWCHK 129 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR-TYTHEVVTLWYRAPEILLGCKY 179 + ++HRD+KP+NLLI+ +KL DFG AR Y EV T WYR+PE+LLG Sbjct: 130 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAP- 188 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 Y +VD+WS+GCI E+ + LFPG+SEIDQLF I + LG P + S Sbjct: 189 YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-------PLPSEQMKLFYS 241 Query: 240 FPKWARQDFSKVVPPLDEDGR----------SLLSQMLHYDPNKRISAKAALAHPFFQ 287 P++ F V P + R L+ +L DP R + L HP FQ Sbjct: 242 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >4MYG-A nrPDB Length = 372 Score = 202 bits (515), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 115/291 (39%), Positives = 163/291 (56%), Gaps = 15/291 (5%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 +G G YG V A +K +GE VA+KK+ ++E A RE+ LLK + H N++ LLDV Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 70 IHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 + L YLV F+ DL+K M I+ ++Q+L+GL + HS V Sbjct: 111 FTPASSLRNFYDFYLVMPFMQTDLQKIMGME----FSEEKIQYLVYQMLKGLKYIHSAGV 166 Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 +HRDLKP NL +N + +K+ DFGLAR + Y VVT WYRAPE++L +Y+ Sbjct: 167 VHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSWMHYNQT 223 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP--DEVVWPGVTSMPDYKPSFP 241 VDIWS+GCI AEM+T + LF G +DQL +I + G P + V + Y S P Sbjct: 224 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 283 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 + R+DF+++ P LL +ML D +KR++A AL HPFF+ P Sbjct: 284 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 334 >4QTB-A nrPDB Length = 380 Score = 201 bits (510), Expect = 4e-52, Method: Compositional matrix adjust. Identities = 113/301 (37%), Positives = 169/301 (56%), Gaps = 16/301 (5%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 + +++ IGEG YG+V A + + VA+KKI E + +REI +L H N+ Sbjct: 43 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENV 101 Query: 64 VKLLDVIHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 + + D++ +Y+V + + DL K + + L+ I +L+Q+L+GL + Sbjct: 102 IGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSN---DHICYFLYQILRGLKYI 158 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT----HEVVTLWYRAPEIL 174 HS VLHRDLKP NLLINT +K+ DFGLAR P +T V T WYRAPEI+ Sbjct: 159 HSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIM 217 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 L K Y+ ++DIWS+GCI AEM++ R +FPG +DQL I LG+P + + +M Sbjct: 218 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 277 Query: 235 --DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 +Y S P + ++K+ P D LL +ML ++PNKRI+ + ALAHP+ + P Sbjct: 278 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 337 Query: 293 V 293 Sbjct: 338 T 338 >3OZ6-A nrPDB Length = 388 Score = 199 bits (505), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 121/330 (36%), Positives = 184/330 (55%), Gaps = 51/330 (15%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59 + ++ V+K+G+G YG+V+K+ ++ TGEVVA+KKI + REI +L EL+ Sbjct: 8 LRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSG 67 Query: 60 HPNIVKLLDVIHTENK--LYLVFEFLHQDLKKFMDASALTGIPLPLIKSYL-FQLLQGLA 116 H NIV LL+V+ +N +YLVF+++ DL + A+ L P+ K Y+ +QL++ + Sbjct: 68 HENIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRANILE----PVHKQYVVYQLIKVIK 123 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE-------------- 162 + HS +LHRD+KP N+L+N E +K+ADFGL+R+F V +R T+ Sbjct: 124 YLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSF-VNIRRVTNNIPLSINENTENFDD 182 Query: 163 --------VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR 214 V T WYRAPEILLG Y+ +D+WSLGCI E++ + +FPG S ++QL R Sbjct: 183 DQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLER 242 Query: 215 IFRTLGTP-----DEVVWPGVTSM------------PDYKPSFPKWARQDFSKVVPPLD- 256 I + P + + P +M + + F KW + K+ P D Sbjct: 243 IIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKW-KNLLLKINPKADC 301 Query: 257 -EDGRSLLSQMLHYDPNKRISAKAALAHPF 285 E+ LL ++L ++PNKRISA AL HPF Sbjct: 302 NEEALDLLDKLLQFNPNKRISANDALKHPF 331 >5Z33-A nrPDB Length = 425 Score = 195 bits (495), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 115/299 (38%), Positives = 165/299 (55%), Gaps = 17/299 (5%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NH 60 E + +++G+G YG+V A N T E VA+KK+ + + A+REI LL+ H Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGH 90 Query: 61 PNIVKLLDVI----HTENKLYLVFEFLHQDLKKFMDASALTGIPL--PLIKSYLFQLLQG 114 NI L D+ N+ YL E + DL + +G PL +S+++Q+L G Sbjct: 91 RNITCLYDMDIPRPDNFNETYLYEELMECDLAAII----RSGQPLTDAHFQSFIYQILCG 146 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP----VRTYTHEVVTLWYRA 170 L + HS VLHRDLKP NLL+N + +K+ DFGLAR F V T V T WYRA Sbjct: 147 LKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRA 206 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 PEI+L + Y+ A+D+WS+GCI AE++ R F G +DQL +I LGTP+E + Sbjct: 207 PEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRI 266 Query: 231 TS--MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 S +Y + P A++ F + P + D LL +ML +DP+ RIS + AL HP+ Sbjct: 267 GSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYLH 325 >3OHT-A nrPDB Length = 389 Score = 194 bits (492), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 112/302 (37%), Positives = 166/302 (54%), Gaps = 20/302 (6%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E +Q + +G G YG V + + +G +A+KK+ ++ RE+ LLK + H Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 110 Query: 62 NIVKLLDV------IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 N++ LLDV + N +YLV + DL + LT + + ++Q+L+GL Sbjct: 111 NVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL---IYQILRGL 167 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 + HS ++HRDLKP NL +N + +K+ DFGLAR + Y V T WYRAPEI+L Sbjct: 168 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIML 224 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP- 234 +Y+ VDIWS+GCI AE++T R LFPG I+QL +I R GTP V ++ MP Sbjct: 225 NWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASV---ISRMPS 281 Query: 235 ----DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 +Y S P+ +++F+ V + LL +ML D +KRI+A ALAHP+F Sbjct: 282 HEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQYH 341 Query: 291 KP 292 P Sbjct: 342 DP 343 >6DTL-A nrPDB Length = 364 Score = 194 bits (492), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 107/286 (37%), Positives = 159/286 (55%), Gaps = 9/286 (3%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 IG+G YG+V A N T E VA+KKI + + +REI LL+ ++H NIV + D+ Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 97 Query: 70 I-----HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 I + N +Y+ +E + DL + + ++ + + +L+Q+L+GL + HS VL Sbjct: 98 IPPPLRNAFNDVYIAYELMDTDLHQIIRSN--QALSEEHCQYFLYQILRGLKYIHSANVL 155 Query: 125 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAV 184 HRDLKP NLL+N +K+ DFGLAR T VVT WYRAPE+LL Y+ A+ Sbjct: 156 HRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLLNSSDYTAAI 214 Query: 185 DIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD-YKPSFPKW 243 D+WS+GCIF E++ R+ LFPG + QL + +GTP E + Y P + Sbjct: 215 DVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPY 274 Query: 244 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 RQ + P + L+ +ML +DP +RI+ ALAHP+ + Sbjct: 275 PRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 320 >5NGU-A nrPDB Length = 381 Score = 193 bits (491), Expect = 6e-50, Method: Compositional matrix adjust. Identities = 112/300 (37%), Positives = 165/300 (55%), Gaps = 16/300 (5%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 + + IGEG YG+V A + L VA+KKI E + +REI +L H NI Sbjct: 44 YTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENI 102 Query: 64 VKLLDVIHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 + + D+I +Y+V + + DL K + L+ I +L+Q+L+GL + Sbjct: 103 IGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSN---DHICYFLYQILRGLKYI 159 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT----HEVVTLWYRAPEIL 174 HS VLHRDLKP NLL+NT +K+ DFGLAR P +T V T WYRAPEI+ Sbjct: 160 HSANVLHRDLKPSNLLLNTTCDLKICDFGLARV-ADPDHDHTGFLTEYVATRWYRAPEIM 218 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 L K Y+ ++DIWS+GCI AEM++ R +FPG +DQL I LG+P + + ++ Sbjct: 219 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 278 Query: 235 --DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 +Y S P + ++++ P D LL +ML ++P+KRI + ALAHP+ + P Sbjct: 279 ARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDP 338 >1CM8-A nrPDB Length = 367 Score = 193 bits (491), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 109/294 (37%), Positives = 163/294 (55%), Gaps = 14/294 (4%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 ++ ++ +G G YG V A + TG VA+KK+ ++E A RE+ LLK + H N+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 64 VKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 + LLDV + L YLV F+ DL K M L I+ ++Q+L+GL + Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE---DRIQFLVYQMLKGLRY 143 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 H+ ++HRDLKP NL +N + +K+ DFGLAR + Y VVT WYRAPE++L Sbjct: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILNW 200 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS--MPD 235 Y+ VDIWS+GCI AEM+T + LF G +DQL I + GTP + S + Sbjct: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 Y P+ ++DF+ ++ +LL +ML D +R++A ALAHP+F+ + Sbjct: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 >4CRL-A nrPDB Length = 406 Score = 192 bits (488), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 124/324 (38%), Positives = 181/324 (55%), Gaps = 46/324 (14%) Query: 9 KIGEGTYGVVYKARNKLTGEVV--ALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 K+G GTYG VYKA+ K + ALK+I E G+ +A REI+LL+EL HPN++ L Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 84 Query: 67 LDVI--HTENKLYLVFEFLHQDLK---KFMDASALTGIPLPL----IKSYLFQLLQGLAF 117 V H + K++L+F++ DL KF AS P+ L +KS L+Q+L G+ + Sbjct: 85 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 144 Query: 118 CHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRA 170 H++ VLHRDLKP N+L+ EG +K+AD G AR F P++ VVT WYRA Sbjct: 145 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 204 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEI---------DQLFRIFRTLGT 221 PE+LLG ++Y+ A+DIW++GCIFAE++T +F E DQL RIF +G Sbjct: 205 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 264 Query: 222 PDEVVWPGVTSMPDYKPSFPKWARQDFS-----------KVVPPLDEDGRSLLSQMLHYD 270 P + W + MP++ + R ++ KV P D LL ++L D Sbjct: 265 PADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKP--DSKAFHLLQKLLTMD 322 Query: 271 PNKRISAKAALAHPFFQDVTKPVP 294 P KRI+++ A+ P+F + P+P Sbjct: 323 PIKRITSEQAMQDPYF--LEDPLP 344 >4EWQ-A nrPDB Length = 383 Score = 191 bits (485), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 112/299 (37%), Positives = 162/299 (54%), Gaps = 14/299 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E +Q + +G G YG V A + TG VA+KK+ ++ RE+ LLK + H Sbjct: 45 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 104 Query: 62 NIVKLLDV------IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 N++ LLDV + N +YLV + DL + LT + + ++Q+L+GL Sbjct: 105 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL---IYQILRGL 161 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 + HS ++HRDLKP NL +N + +K+ DFGLAR + Y V T WYRAPEI+L Sbjct: 162 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIML 218 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP- 234 +Y+ VDIWS+GCI AE++T R LFPG IDQL I R +GTP + ++S Sbjct: 219 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 278 Query: 235 -DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 +Y S + + +F+ V + LL +ML D +KRI+A ALAH +F P Sbjct: 279 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 337 >2F9G-A nrPDB Length = 353 Score = 191 bits (485), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 114/309 (36%), Positives = 161/309 (52%), Gaps = 24/309 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR-LDTETEGVPSTAIREISLLKELNHP 61 +FQ +GEG YGVV A +K TGE+VA+KKI D + +REI +LK H Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFAL--RTLREIKILKHFKHE 69 Query: 62 NIVKLLDVIHTE-----NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 NI+ + ++ + N++Y++ E + DL + + L+ I+ +++Q L+ + Sbjct: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSD---DHIQYFIYQTLRAVK 126 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV----------RTYTHEVVTL 166 H V+HRDLKP NLLIN+ +K+ DFGLAR T V T Sbjct: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 Query: 167 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVV 226 WYRAPE++L YS A+D+WS GCI AE+ RR +FPG QL IF +GTP Sbjct: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Query: 227 WPGVTSMP---DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAH 283 P +Y S P + K+ P ++ G LL +ML +DP KRI+AK AL H Sbjct: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 Query: 284 PFFQDVTKP 292 P+ Q P Sbjct: 307 PYLQTYHDP 315 >3ZDU-A nrPDB Length = 325 Score = 191 bits (485), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 107/297 (36%), Positives = 164/297 (55%), Gaps = 22/297 (7%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME ++ + K+GEG+YG V K ++K TG++VA+K I + + V A+REI LK+ +H Sbjct: 2 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHH 60 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 N+V L++V + K++LVFEF+ H L + G+ ++ YLFQ+L+ + + H Sbjct: 61 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCH--GLESKRLRKYLFQILRAIDYLH 118 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 S+ ++HRD+KP+N+L++ G KL DFG AR P Y EV T WYRAPE++L Sbjct: 119 SNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTS 178 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 Y VDIW+LGC+ EM T P S++D L +I +G + P + ++ P Sbjct: 179 YGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGN----LSPHLQNIFSKSPI 234 Query: 240 F----------PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 F PK AR+ + P L+ ++ L DP RIS+ L H +F Sbjct: 235 FAGVVLPQVQHPKNARKKY----PKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 287 >3GC9-A nrPDB Length = 370 Score = 187 bits (476), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 109/299 (36%), Positives = 162/299 (54%), Gaps = 14/299 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + Q + +G G YG V A + + VA+KK+ ++ RE+ LLK L H Sbjct: 28 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 87 Query: 62 NIVKLLDV------IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 N++ LLDV I +++YLV + DL + + AL+ + + ++QLL+GL Sbjct: 88 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQALSDEHVQFL---VYQLLRGL 144 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 + HS ++HRDLKP N+ +N + +++ DFGLAR + Y V T WYRAPEI+L Sbjct: 145 KYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGY---VATRWYRAPEIML 201 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS--M 233 +Y+ VDIWS+GCI AE++ +ALFPG IDQL RI +GTP V ++S Sbjct: 202 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 261 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 Y S P ++D S + + LL +ML D ++R+SA ALAH +F P Sbjct: 262 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 320 >3RP9-A nrPDB Length = 458 Score = 181 bits (459), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 125/346 (36%), Positives = 170/346 (49%), Gaps = 69/346 (19%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 IG G+YG V +A +KL VVA+KKI E +REI++L LNH ++VK+LD+ Sbjct: 61 IGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDI 120 Query: 70 IHTEN-----KLYLVFEFLHQDLKK-FMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 + ++ +LY+V E D KK F LT + IK+ L+ LL G+ + HS + Sbjct: 121 VIPKDVEKFDELYVVLEIADSDFKKLFRTPVYLTELH---IKTLLYNLLVGVKYVHSAGI 177 Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVP---------------------------V 156 LHRDLKP N L+N + ++K+ DFGLAR P Sbjct: 178 LHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLK 237 Query: 157 RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-----------RRALFPG 205 R T VVT WYRAPE++L + Y+ A+D+WS+GCIFAE++ R LFPG Sbjct: 238 RQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPG 297 Query: 206 DS--------------------EIDQLFRIFRTLGTPDEVVWPGV--TSMPDYKPSFPKW 243 S DQL IF LGTP E + Y FPK Sbjct: 298 SSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIFPKR 357 Query: 244 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 D ++ P D LL +ML ++PNKRI+ LAHPFF++V Sbjct: 358 EGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEV 403 >4E7W-A nrPDB Length = 394 Score = 177 bits (450), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 110/299 (36%), Positives = 171/299 (57%), Gaps = 25/299 (8%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 + + IG G++GVV++A+ + EV A+KK+ D + RE+ +++ + HPN+ Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDEV-AIKKVLQDKRFKN------RELQIMRIVKHPNV 94 Query: 64 VKLLDVIHTENK------LYLVFEFLHQDLKKFMD--ASALTGIPLPLIKSYLFQLLQGL 115 V L ++ L LV E++ + + + A +P+ LIK Y++QLL+ L Sbjct: 95 VDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSL 154 Query: 116 AFCHSHRVLHRDLKPQNLLINT-EGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPE 172 A+ HS + HRD+KPQNLL++ G +KL DFG A+ G P +Y + + +YRAPE Sbjct: 155 AYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSY---ICSRYYRAPE 211 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 ++ G Y+T +DIWS GC+ AE++ + LFPG+S IDQL I + LGTP T Sbjct: 212 LIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIK--TM 269 Query: 233 MPDY-KPSFPKWARQDFSKVV-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 P+Y + FP+ FSKV P D L+S++L Y P+ R++A AL HPFF ++ Sbjct: 270 NPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDEL 328 >3FI2-A nrPDB Length = 353 Score = 176 bits (447), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 114/310 (36%), Positives = 164/310 (52%), Gaps = 33/310 (10%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ +Q ++ IG G G+V A + + VA+KK+ + + A RE+ L+K +NH Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 82 Query: 61 PNIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQ 110 NI+ LL+V + L YLV E MDA+ I + L + L+Q Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYLVMEL--------MDANLCQVIQMELDHERMSYLLYQ 134 Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 +L G+ HS ++HRDLKP N+++ ++ +K+ DFGLAR G T VVT +YRA Sbjct: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRA 193 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP-DEVVWPG 229 PE++LG Y VDIWS+GCI EMV + LFPG IDQ ++ LGTP E + Sbjct: 194 PEVILGMGYKEN-VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 252 Query: 230 VTSMPDYKPSFPKWARQDFSKVVP----PLDED--------GRSLLSQMLHYDPNKRISA 277 ++ +Y + PK+A F K+ P P D + R LLS+ML DP KRIS Sbjct: 253 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 312 Query: 278 KAALAHPFFQ 287 AL HP+ Sbjct: 313 DDALQHPYIN 322 >1JNK-A nrPDB Length = 423 Score = 176 bits (447), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 117/325 (36%), Positives = 169/325 (52%), Gaps = 39/325 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ +Q ++ IG G G+V A + + VA+KK+ + + A RE+ L+K +NH Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 61 PNIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQ 110 NI+ LL+V + L YLV E MDA+ I + L + L+Q Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMEL--------MDANLCQVIQMELDHERMSYLLYQ 172 Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 +L G+ HS ++HRDLKP N+++ ++ +K+ DFGLAR G T VVT +YRA Sbjct: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRA 231 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP-DEVVWPG 229 PE++LG Y VDIWS+GCI EMV + LFPG IDQ ++ LGTP E + Sbjct: 232 PEVILGMGYKEN-VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 Query: 230 VTSMPDYKPSFPKWARQDFSKVVP----PLDED--------GRSLLSQMLHYDPNKRISA 277 ++ +Y + PK+A F K+ P P D + R LLS+ML DP KRIS Sbjct: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 Query: 278 KAALAHPFFQ------DVTKPVPHL 296 AL HP+ +V P P + Sbjct: 351 DDALQHPYINVWYDPAEVEAPPPQI 375 >5AIR-A nrPDB Length = 430 Score = 175 bits (443), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 101/303 (33%), Positives = 177/303 (58%), Gaps = 24/303 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 ++ + IG G++GVVY+A+ +GE+VA+KK+ D + RE+ ++++L+H N Sbjct: 65 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCN 118 Query: 63 IVKLLDVIHTENK------LYLVFEFLHQDLKKFMD--ASALTGIPLPLIKSYLFQLLQG 114 IV+L ++ + L LV +++ + + + + A +P+ +K Y++QL + Sbjct: 119 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 178 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAI-KLADFGLARAF--GVPVRTYTHEVVTLWYRAP 171 LA+ HS + HRD+KPQNLL++ + A+ KL DFG A+ G P +Y + + +YRAP Sbjct: 179 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAP 235 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWPGV 230 E++ G Y++++D+WS GC+ AE++ + +FPGDS +DQL I + LGTP E + Sbjct: 236 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 295 Query: 231 TSMPDYKPSFPKWARQDFSKVV-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 + ++K FP+ ++KV P + +L S++L Y P R++ A AH FF ++ Sbjct: 296 PNYTEFK--FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDEL 353 Query: 290 TKP 292 P Sbjct: 354 RDP 356 >4O2Z-A nrPDB Length = 377 Score = 171 bits (434), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 100/292 (34%), Positives = 159/292 (54%), Gaps = 25/292 (8%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 +G G YG+ + TGE V++KK R +REI +++ +H N++ ++++ Sbjct: 53 LGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENLLNVVNI 112 Query: 70 I-------HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 + H+ +Y+V + D+ + + + + ++ +++Q+L+GL + HS Sbjct: 113 LPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQV--LEESHMQYFVYQILRGLKYLHSAN 170 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182 V HRDLKP NL+ N +K+ DFGL+R+ VP T V+T WYR PE+LL YST Sbjct: 171 VAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLLENTNYST 230 Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVV------WPGVTSMPDY 236 AVDIWS+GCIFAEM R+ +FPG + +DQL I + +G P + + +PD Sbjct: 231 AVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREALEKLNELPDG 290 Query: 237 KPSFPKWARQDFSKVVPPL--DEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 + P K+VP L + +G LS+M DP+KR +A LAHP+ Sbjct: 291 SLNIP--------KLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYL 334 >3EB0-A nrPDB Length = 383 Score = 171 bits (433), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 106/322 (32%), Positives = 172/322 (53%), Gaps = 56/322 (17%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 +G G++G+V + + +G+ ALKK+ D P RE+ ++K L+H NI+KL+D Sbjct: 15 LGTGSFGIVCEVFDIESGKRFALKKVLQD------PRYKNRELDIMKVLDHVNIIKLVDY 68 Query: 70 IHT-------------------------------------ENK-LYLVFEF----LHQDL 87 +T +NK L ++ E+ LH+ L Sbjct: 69 FYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHKVL 128 Query: 88 KKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT-EGAIKLADF 146 K F+ + IP+ LI Y++QL + + F HS + HRD+KPQNLL+N+ + +KL DF Sbjct: 129 KSFIRSGR--SIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDF 186 Query: 147 GLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGD 206 G A+ +P + + +YRAPE++LG Y+ ++D+WS+GC+F E++ + LF G+ Sbjct: 187 GSAKKL-IPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGE 245 Query: 207 SEIDQLFRIFRTLGTPDEVVWPGVTSMPDY-KPSFPKWARQDFSKVVPPLDED-GRSLLS 264 + IDQL RI + +GTP + + P Y + FP +D+ K++P LL Sbjct: 246 TSIDQLVRIIQIMGTPTKEQM--IRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAIDLLE 303 Query: 265 QMLHYDPNKRISAKAALAHPFF 286 Q+L Y+P+ RI+ A+AHPFF Sbjct: 304 QILRYEPDLRINPYEAMAHPFF 325 >3N9X-A nrPDB Length = 432 Score = 171 bits (433), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 116/339 (34%), Positives = 162/339 (47%), Gaps = 59/339 (17%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 IG G+YG VY A +K T + VA+KK+ E +REI++L L I++L D+ Sbjct: 34 IGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLYDL 93 Query: 70 IHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 I ++ +LY+V E DLKK + IK+ L+ LL G F H ++ Sbjct: 94 IIPDDLLKFDELYIVLEIADSDLKKLFKTPIF--LTEEHIKTILYNLLLGENFIHESGII 151 Query: 125 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT----------------------YTHE 162 HRDLKP N L+N + ++K+ DFGLAR T T Sbjct: 152 HRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQLTSH 211 Query: 163 VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMV-----------TRRALFPGD----- 206 VVT WYRAPE++L + Y+ ++DIWS GCIFAE++ R LFPG Sbjct: 212 VVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLFPGSSCFPL 271 Query: 207 ------------SEIDQLFRIFRTLGTPDEVVWPGVT--SMPDYKPSFPKWARQDFSKVV 252 S DQL IF +GTP E + + Y FP + + Sbjct: 272 SPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHRKPINLKQKY 331 Query: 253 PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 P + +DG +LL ML ++PNKRI+ AL HP+ +DV K Sbjct: 332 PSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRK 370 >2XS0-A nrPDB Length = 386 Score = 170 bits (431), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 110/310 (35%), Positives = 161/310 (51%), Gaps = 33/310 (10%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ +Q ++ IG G G+V A + + VA+KK+ + + A RE+ L+K +NH Sbjct: 25 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 84 Query: 61 PNIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQ 110 NI+ LL+V + L Y+V E MDA+ I + L + L+Q Sbjct: 85 KNIIGLLNVFTPQKSLEEFQDVYIVMEL--------MDANLCQVIQMELDHERMSYLLYQ 136 Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 +L G+ HS ++HRDLKP N+++ ++ +K+ DFGLAR G VVT +YRA Sbjct: 137 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPF-VVTRYYRA 195 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP-DEVVWPG 229 PE++LG Y VDIWS+GCI EM+ LFPG IDQ ++ LGTP E + Sbjct: 196 PEVILGMGYKEN-VDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKL 254 Query: 230 VTSMPDYKPSFPKWARQDFSKVVP----PLDED--------GRSLLSQMLHYDPNKRISA 277 ++ Y + PK+A F K+ P P D + R LLS+ML D +KRIS Sbjct: 255 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 314 Query: 278 KAALAHPFFQ 287 AL HP+ Sbjct: 315 DEALQHPYIN 324 >3E7O-A nrPDB Length = 360 Score = 169 bits (428), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 109/309 (35%), Positives = 164/309 (53%), Gaps = 33/309 (10%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ +Q+++ IG G G+V A + + G VA+KK+ + + A RE+ LLK +NH Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 80 Query: 61 PNIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQ 110 NI+ LL+V + L YLV E MDA+ I + L + L+Q Sbjct: 81 KNIISLLNVFTPQKTLEEFQDVYLVMEL--------MDANLCQVIHMELDHERMSYLLYQ 132 Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 +L G+ HS ++HRDLKP N+++ ++ +K+ DFGLAR T VVT +YRA Sbjct: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNF-MMTPYVVTRYYRA 191 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD----EVV 226 PE++LG Y VDIWS+GCI E+V +F G IDQ ++ LGTP + Sbjct: 192 PEVILGMGYKEN-VDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAAL 250 Query: 227 WPGVTSMPDYKPSFPKWARQD-FSKVVPPLDED--------GRSLLSQMLHYDPNKRISA 277 P V + + +P++P A ++ F + P + + R LLS+ML DP+KRIS Sbjct: 251 QPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISV 310 Query: 278 KAALAHPFF 286 AL HP+ Sbjct: 311 DEALRHPYI 319 >5AWM-A nrPDB Length = 394 Score = 167 bits (422), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 111/315 (35%), Positives = 159/315 (50%), Gaps = 40/315 (12%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 IG G G+V A + +T + VA+KK+ + A RE L+K +NH NI+ LL+ Sbjct: 52 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 111 Query: 70 IHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQLLQGLAFCH 119 + L YLV E MDA+ I + L + L+Q+L G+ H Sbjct: 112 FTPQRNLEEFQDVYLVMEL--------MDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLH 163 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 S ++HRDLKP N+++ + +K+ DFGLAR G T VVT +YRAPE++LG Sbjct: 164 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVILGMG- 221 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT-SMPDYKP 238 Y+ VDIWS+GCI EM+ LFPG IDQ +I LGTP + ++ +Y Sbjct: 222 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 281 Query: 239 SFPKWARQDFSKVVP----PLDE---------DGRSLLSQMLHYDPNKRISAKAALAHPF 285 + P++ F ++ P P D D R+LLS+ML DP +RIS AL H + Sbjct: 282 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 341 Query: 286 F------QDVTKPVP 294 ++V P P Sbjct: 342 INVWYDAEEVDAPAP 356 >3NIE-A nrPDB Length = 429 Score = 166 bits (421), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 115/350 (32%), Positives = 163/350 (46%), Gaps = 62/350 (17%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +N++ IG G+YG VY A +K + VA+KK+ E +REI++L L Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 62 NIVKLLDVIHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 I++L D+I E+ +LY+V E DLKK + +K+ L+ LL G Sbjct: 88 YIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIF--LTEQHVKTILYNLLLGEK 145 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--------------------- 155 F H ++HRDLKP N L+N + ++K+ DFGLAR Sbjct: 146 FIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPH 205 Query: 156 ----VRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMV-----------TRR 200 + T VVT WYRAPE++L + Y+ ++DIWS GCIFAE++ R Sbjct: 206 NKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRF 265 Query: 201 ALFPGD-----------------SEIDQLFRIFRTLGTPDEVVWPGVTSMP--DYKPSFP 241 LFPG S DQL IF +GTP E +T Y FP Sbjct: 266 PLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFP 325 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 D SK + ++G LL ML ++ KRI+ AL+HP+ +DV K Sbjct: 326 TRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRK 375 >3PG1-A nrPDB Length = 362 Score = 166 bits (420), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 105/302 (34%), Positives = 162/302 (53%), Gaps = 22/302 (7%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEG----------VPSTAIREISLLKELN 59 I G+YG V + G VA+K++ +T ++G + +REI LL + Sbjct: 30 ISSGSYGAVCAGVDS-EGIPVAIKRV-FNTVSDGRTVNILSDSFLCKRVLREIRLLNHFH 87 Query: 60 HPNIVKLLDV-IHTE----NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 HPNI+ L D+ +H E +KLYLV E + DL + + + P I+ +++ +L G Sbjct: 88 HPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISP-QHIQYFMYHILLG 146 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 L H V+HRDL P N+L+ I + DF LAR TH V WYRAPE++ Sbjct: 147 LHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANK-THYVTHRWYRAPELV 205 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP--DEVVWPGVTS 232 + K ++ VD+WS GC+ AEM R+ALF G + +QL +I +GTP ++VV S Sbjct: 206 MQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMFSSPS 265 Query: 233 MPDY-KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 DY + S + ++ VVP D L+++ML ++P +RIS + AL HP+F+ + Sbjct: 266 ARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFESLFD 325 Query: 292 PV 293 P+ Sbjct: 326 PL 327 >3E3P-A nrPDB Length = 360 Score = 166 bits (420), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 110/315 (34%), Positives = 162/315 (51%), Gaps = 27/315 (8%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-- 58 M+ FQ G+GT+G V + K TG VA+KK+ D P RE+ ++++L Sbjct: 22 MDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQD------PRFRNRELQIMQDLAV 75 Query: 59 -NHPNIVKLLDVIHTENK-------LYLVFEFLHQDLKKFMDASALTGIPLP--LIKSYL 108 +HPNIV+L +T + L +V E++ L + + P LIK +L Sbjct: 76 LHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFL 135 Query: 109 FQLLQGLAFCH--SHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVT 165 FQL++ + H S V HRD+KP N+L+N +G +KL DFG A+ P + + Sbjct: 136 FQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLS-PSEPNVAYICS 194 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEV 225 +YRAPE++ G ++Y+TAVDIWS+GCIFAEM+ +F GD+ QL I R LG P Sbjct: 195 RYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSRE 254 Query: 226 VW----PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281 V P T + Y W+ FS ++ LLS +L Y P +R+ AL Sbjct: 255 VLRKLNPSHTDVDLYNSKGIPWSNV-FSDHSLKDAKEAYDLLSALLQYLPEERMKPYEAL 313 Query: 282 AHPFFQDVTKPVPHL 296 HP+F ++ P L Sbjct: 314 CHPYFDELHDPATKL 328 >4QNY-A nrPDB Length = 354 Score = 165 bits (418), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 94/287 (32%), Positives = 153/287 (53%), Gaps = 11/287 (3%) Query: 10 IGEGTYGVVYKARN-KLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELNHPNIVKLL 67 IG G+YGVV +AR+ K +VA+K++ + E + + I REI LL N NI+ L Sbjct: 28 IGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNIIGLR 87 Query: 68 DVIHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 +++ E+ Y+V + + DLK+ + + + I+ +++Q L+ L HS Sbjct: 88 NILTPEDPENFDHFYIVMDIMETDLKQVLRSG--QELTEAHIQFFIYQALRALHIIHSAG 145 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182 V+HRD+ P N+L+NT +K+ DFGLA+ T V WYRAPE+++ K YS Sbjct: 146 VIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEDKDYSA 205 Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDE--VVWPGVTSMPDYKPSF 240 +D+W +GCI E++ R LF G ++QL +I +GTP E + G ++ Y Sbjct: 206 QIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAAQKYLKKK 265 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 + D+ + P + LL ML ++P +RI+ A+ HPF + Sbjct: 266 SHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLE 312 >2I6L-A nrPDB Length = 320 Score = 164 bits (414), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 106/322 (32%), Positives = 175/322 (54%), Gaps = 50/322 (15%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 + ++ +G G G+V+ A + + VA+KKI L T+ + V A+REI +++ L+H NI Sbjct: 13 YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVL-TDPQSV-KHALREIKIIRRLDHDNI 70 Query: 64 VKLLDVIH-------------TE-NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKS--- 106 VK+ +++ TE N +Y+V E++ DL ++ PL++ Sbjct: 71 VKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQG-------PLLEEHAR 123 Query: 107 -YLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHE-- 162 +++QLL+GL + HS VLHRDLKP NL INTE +K+ DFGLAR Y+H+ Sbjct: 124 LFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMD---PHYSHKGH 180 Query: 163 ----VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRT 218 +VT WYR+P +LL Y+ A+D+W+ GCIFAEM+T + LF G E++Q+ I + Sbjct: 181 LSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILES 240 Query: 219 LGTPDEVVWPGVTSMPDYKPSFPKWARQD-------FSKVVPPLDEDGRSLLSQMLHYDP 271 + E + S+ P + R D ++++P + + L Q+L + P Sbjct: 241 IPVVHEEDRQELLSV------IPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSP 294 Query: 272 NKRISAKAALAHPFFQDVTKPV 293 R++A+ AL+HP+ + P+ Sbjct: 295 MDRLTAEEALSHPYMSIYSFPM 316 >5ZTN-A nrPDB Length = 429 Score = 138 bits (348), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 93/319 (29%), Positives = 159/319 (49%), Gaps = 39/319 (12%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL---NH 60 ++ ++ IG+G++G V KA + + VALK +R + + IR + L++ N Sbjct: 99 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT 158 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 N++ +L+ N + + FE L +L + + + G LPL++ + +LQ L H Sbjct: 159 MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK 218 Query: 121 HRVLHRDLKPQNLLINTEG--AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 +R++H DLKP+N+L+ +G IK+ DFG + V TY + + +YRAPE++LG + Sbjct: 219 NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTY---IQSRFYRAPEVILGAR 275 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y +D+WSLGCI AE++T L PG+ E DQL + LG P + + ++ Sbjct: 276 -YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVS 334 Query: 239 S--FPKW-----------------ARQDFSKVVPPLDEDGRSL-----------LSQMLH 268 S +P++ +R+ + P E G +L L Q L Sbjct: 335 SKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLE 394 Query: 269 YDPNKRISAKAALAHPFFQ 287 +DP R++ AL HP+ + Sbjct: 395 WDPAVRMTPGQALRHPWLR 413 >5YKS-A nrPDB Length = 377 Score = 137 bits (344), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 100/293 (34%), Positives = 145/293 (49%), Gaps = 46/293 (15%) Query: 10 IGEGTYGVVYKARNKLTGEVVALK---KIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 +G G + VV AR+ TGE VA+K K +LDT G +E+ +K + HPNIV+L Sbjct: 43 LGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATG---HLFQEVRCMKLVQHPNIVRL 99 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMD--ASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 +VI T+ KLYL+ E D D G+ L K Y Q++ +++CH V+ Sbjct: 100 YEVIDTQTKLYLILEL--GDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVV 157 Query: 125 HRDLKPQNLLI-NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 HRDLKP+N++ +G +KL DFG + F P + T +L Y APEILLG +Y + A Sbjct: 158 HRDLKPENVVFFEKQGLVKLTDFGFSNKFQ-PGKKLTTSCGSLAYSAPEILLGDEYDAPA 216 Query: 184 VDIWSLGCIFAEMVTRRALF--PGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 VDIWSLG I +V + F DSE +T + D K + P Sbjct: 217 VDIWSLGVILFMLVCGQPPFQEANDSET--------------------LTMIMDCKYTVP 256 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 + ++ + L+++ML DP +R S + HP+ Q V P P Sbjct: 257 SH-----------VSKECKDLITRMLQRDPKRRASLEEIENHPWLQGV-DPSP 297 >5Y86-A nrPDB Length = 588 Score = 135 bits (339), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 96/326 (29%), Positives = 163/326 (50%), Gaps = 42/326 (12%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP-- 61 ++ ++ IG+G++G V + + + VALK +R + + IR + LK+ + Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268 Query: 62 -NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 N++ +L+ N + + FE L DL + + + G + L++ + +LQ L H Sbjct: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328 Query: 121 HRVLHRDLKPQNLLINTEG--AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 ++++H DLKP+N+L+ G + K+ DFG + + TY + + +YRAPEI+LG + Sbjct: 329 NKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTY---IQSRFYRAPEIILGSR 385 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVV------------ 226 Y ST +DIWS GCI AE++T + LFPG+ E DQL + LG P + Sbjct: 386 Y-STPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444 Query: 227 ------WPGVTSMPDYKPSFPKWARQDFSKVVPPLDED-GRSL-----------LSQMLH 268 + VT+ D + + K PP +D G +L L + LH Sbjct: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLH 504 Query: 269 YDPNKRISAKAALAHPFFQDVTKPVP 294 +DP+ R++ AL HP+ ++K VP Sbjct: 505 WDPSARLTPAQALRHPW---ISKSVP 527 >5XVU-A nrPDB Length = 332 Score = 133 bits (335), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 97/304 (31%), Positives = 157/304 (51%), Gaps = 33/304 (10%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH-PN 62 ++ ++KIG G Y V+ + A+K REI +L+ LN PN Sbjct: 33 YEIMKKIGRGKYSEVFNGYDTECNRPCAIK-----VLKPVKKKKIKREIKILQNLNGGPN 87 Query: 63 IVKLLDVIH--TENKLYLVFEFLHQ-DLK----KFMDASALTGIPLPLIKSYLFQLLQGL 115 I+KLLD++ L+FE+++ D K KF D I+ Y++Q+L+ L Sbjct: 88 IIKLLDIVKDPVTKTPSLIFEYINNIDFKTLYPKFTDKD---------IRYYIYQILKAL 138 Query: 116 AFCHSHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 +CHS ++HRD+KP N++I+ E I+L +GLA F P + Y V + +Y+ PE+L Sbjct: 139 DYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAE-FYHPGQEYNVRVASRYYKGPELL 197 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEIDQLFRIFRTLGTPDEVVW---PGV 230 + + Y ++DIWSLGC+ A M+ ++ F G DQL +I + LGT D + + Sbjct: 198 IDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNI 257 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGR-----SLLSQMLHYDPNKRISAKAALAHPF 285 P Y ++ R+ +S + + D L+ +ML YD KRI+ K A+ HP+ Sbjct: 258 KLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEHPY 317 Query: 286 FQDV 289 F++V Sbjct: 318 FREV 321 >3LIJ-A nrPDB Length = 494 Score = 133 bits (334), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 92/301 (30%), Positives = 146/301 (48%), Gaps = 52/301 (17%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E +Q+V+K+G G YG V R+K+T A+K IR + + S + E+++LK L+HP Sbjct: 37 EMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHP 96 Query: 62 NIVKLLDVIHTENKLYLVF----------EFLHQDLKKFMDASALTGIPLPLIKSYLFQL 111 NI+KL D + YLV E +H+ KF + A I Q+ Sbjct: 97 NIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHR--MKFNEVDAAVIIK---------QV 145 Query: 112 LQGLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWY 168 L G+ + H H ++HRDLKP+NLL+ + + IK+ DFGL+ F + + T +Y Sbjct: 146 LSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQ-KKMKERLGTAYY 204 Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228 APE+L K Y D+WS+G I ++ F G ++ + L ++ + T D W Sbjct: 205 IAPEVLR--KKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWK 262 Query: 229 GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 V+ E + L+ QML +D +RISA+ AL HP+ ++ Sbjct: 263 NVS-------------------------EGAKDLIKQMLQFDSQRRISAQQALEHPWIKE 297 Query: 289 V 289 + Sbjct: 298 M 298 >4MVF-A nrPDB Length = 506 Score = 133 bits (334), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 87/295 (29%), Positives = 149/295 (50%), Gaps = 36/295 (12%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 EK+G+GTYG VYK +K+T ++ A+K+ + D + +EI ++K+L+HPNIVKL Sbjct: 63 EKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKN--INRFFQEIEIMKKLDHPNIVKLY 120 Query: 68 DVIHTENKLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 + +N +YL+ E ++ D+ G + + Q+ + + HS ++HR Sbjct: 121 ETYENDNYIYLIMELCSG--RELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVHR 178 Query: 127 DLKPQNLLINTEGA---IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 DLKP+N L +E +K+ DFGL++ G T T + T +Y AP++L G Y Sbjct: 179 DLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFT-TTKAGTPYYVAPQVLDG--KYDKK 235 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW 243 DIWS G I ++ F GD++ + L ++ + E W ++S Sbjct: 236 CDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISS----------- 284 Query: 244 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298 D ++L++++L Y+PN+R + + AL HP+ +TK H+ L Sbjct: 285 --------------DAKNLITKLLTYNPNERCTIEEALNHPWITQMTKSHEHVEL 325 >6HMD-A nrPDB Length = 365 Score = 132 bits (331), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 92/304 (30%), Positives = 151/304 (49%), Gaps = 25/304 (8%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +++Q V K+G G Y V++A N E + + + L Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNE----RVVVKILKPVKKKKIKREVKILENLRGGT 108 Query: 62 NIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 NI+KL+D + LVFE+++ D K+ LT I+ Y+++LL+ L +C Sbjct: 109 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--QILTDFD---IRFYMYELLKALDYC 163 Query: 119 HSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 HS ++HRD+KP N++I+ + ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 164 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLVDY 222 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 + Y ++D+WSLGC+ A M+ RR F G DQL RI + LGT +E+ D Sbjct: 223 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT-EELYGYLKKYHIDL 281 Query: 237 KPSF---------PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 P F +W S+ + + LL ++L YD +R++AK A+ HP+F Sbjct: 282 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 341 Query: 288 DVTK 291 V K Sbjct: 342 PVVK 345 >3NCG-A nrPDB Length = 486 Score = 131 bits (330), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 87/306 (28%), Positives = 147/306 (48%), Gaps = 48/306 (15%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E + V +G+G++G V K ++++T + A+K I + ST +RE+ LLK+L+HP Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 62 NIVKLLDVIHTENKLYLVFEF-----LHQDL---KKFMDASALTGIPLPLIKSYLFQLLQ 113 NI+KL +++ + Y+V E L ++ K+F + A I Q+ Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIK---------QVFS 132 Query: 114 GLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 G+ + H H ++HRDLKP+N+L+ + + IK+ DFGL+ F + + T +Y A Sbjct: 133 GITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKM-KDRIGTAYYIA 191 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 PE+L G Y D+WS G I +++ F G +E D L R+ Sbjct: 192 PEVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV--------------- 234 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 Y P+W + +D + L+ +ML + P+ RI+A L HP+ Q + Sbjct: 235 -ETGKYAFDLPQWR---------TISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYS 284 Query: 291 KPVPHL 296 P + Sbjct: 285 SETPTI 290 >2PVN-A nrPDB Length = 352 Score = 130 bits (326), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 94/304 (30%), Positives = 158/304 (51%), Gaps = 29/304 (9%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NH 60 ++++ V K+G G Y V++ N E K + REI +L+ L Sbjct: 52 DDYEVVRKVGRGKYSEVFEGINVNNNE-----KCIIKILKPVKKKKIKREIKILQNLCGG 106 Query: 61 PNIVKLLDVIHTENKL--YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 PNIVKLLD++ ++ L+FE+++ K + LT I+ Y+++LL+ L +C Sbjct: 107 PNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVL-YPTLTDYD---IRYYIYELLKALDYC 162 Query: 119 HSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 HS ++HRD+KP N++I+ E ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 163 HSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAE-FYHPGKEYNVRVASRYFKGPELLVDL 221 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEIDQLFRIFRTLGTPDEVVW--------- 227 + Y ++D+WSLGC+FA M+ R+ F G DQL +I + LGT + Sbjct: 222 QDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELD 281 Query: 228 PGVTSMPDYKPSFP--KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 P + ++ P K+ D +V P + L ++L YD +R++A A+ HP+ Sbjct: 282 PQLEALVGRHSRKPWLKFMNADNQHLVSP---EAIDFLDKLLRYDHQERLTALEAMTHPY 338 Query: 286 FQDV 289 FQ V Sbjct: 339 FQQV 342 >3DXN-A nrPDB Length = 287 Score = 129 bits (325), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 91/292 (31%), Positives = 149/292 (51%), Gaps = 41/292 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELNH 60 + +Q+V+K+G G YG V ++KLTG A+K I+ + T S A+ E+++LK+L+H Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 61 PNIVKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 PNI+KL + + YLV E + + + + + +I + Q+L G + Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVI---MKQVLSGTTYL 137 Query: 119 HSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 H H ++HRDLKP+NLL+ + + IK+ DFGL+ F V + + T +Y APE+L Sbjct: 138 HKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKM-KERLGTAYYIAPEVLR 196 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 K Y D+WS G I ++ F G ++ + L R+ + Sbjct: 197 --KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKG----------------- 237 Query: 236 YKPSF--PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 K SF P W + + ++ + L+ ML Y+P+KRISA+ AL HP+ Sbjct: 238 -KFSFDPPDWTQ---------VSDEAKQLVKLMLTYEPSKRISAEEALNHPW 279 >3DFA-A nrPDB Length = 286 Score = 129 bits (325), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 86/297 (28%), Positives = 144/297 (48%), Gaps = 48/297 (16%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E + V +G+G++G V K ++++T + A+K I + ST +RE+ LLK+L+HP Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 62 NIVKLLDVIHTENKLYLVFEF-----LHQDL---KKFMDASALTGIPLPLIKSYLFQLLQ 113 NI+KL +++ + Y+V E L ++ K+F + A I Q+ Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIK---------QVFS 132 Query: 114 GLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 G+ + H H ++HRDLKP+N+L+ + + IK+ DFGL+ F + + T +Y A Sbjct: 133 GITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKM-KDRIGTAYYIA 191 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 PE+L G Y D+WS G I +++ F G +E D L R+ Sbjct: 192 PEVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV--------------- 234 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 Y P+W + +D + L+ +ML + P+ RI+A L HP+ Q Sbjct: 235 -ETGKYAFDLPQWR---------TISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQ 281 >2WQN-A nrPDB Length = 310 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 80/212 (37%), Positives = 110/212 (51%), Gaps = 9/212 (4%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL-DTETEGVPSTAIREISLLKELN 59 + NF+ +KIG G + VY+A L G VALKK+++ D + I+EI LLK+LN Sbjct: 31 LANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLN 90 Query: 60 HPNIVKLLDVIHTENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 HPN++K +N+L +V E L + +K F L IP + Y QL Sbjct: 91 HPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRL--IPERTVWKYFVQLCSA 148 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 L HS RV+HRD+KP N+ I G +KL D GL R F V T +Y +PE + Sbjct: 149 LEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI 208 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGD 206 Y+ DIWSLGC+ EM ++ F GD Sbjct: 209 HE-NGYNFKSDIWSLGCLLYEMAALQSPFYGD 239 >3HZT-A nrPDB Length = 467 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 91/292 (31%), Positives = 149/292 (51%), Gaps = 41/292 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELNH 60 + +Q+V+K+G G YG V ++KLTG A+K I+ + T S A+ E+++LK+L+H Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 61 PNIVKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 PNI+KL + + YLV E + + + + + +I + Q+L G + Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVI---MKQVLSGTTYL 120 Query: 119 HSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 H H ++HRDLKP+NLL+ + + IK+ DFGL+ F V + + T +Y APE+L Sbjct: 121 HKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKM-KERLGTAYYIAPEVLR 179 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 K Y D+WS G I ++ F G ++ + L R+ + Sbjct: 180 --KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKG----------------- 220 Query: 236 YKPSF--PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 K SF P W + + ++ + L+ ML Y+P+KRISA+ AL HP+ Sbjct: 221 -KFSFDPPDWTQ---------VSDEAKQLVKLMLTYEPSKRISAEEALNHPW 262 >6EII-A nrPDB Length = 352 Score = 128 bits (322), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 89/303 (29%), Positives = 153/303 (50%), Gaps = 23/303 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +++Q V K+G G Y V++A N E V +K + L P Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKI----LKPVKKKKIKREIKILENLRGGP 115 Query: 62 NIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 NI+ L D++ LVFE ++ D K+ LT I+ Y++++L+ L +C Sbjct: 116 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYD---IRFYMYEILKALDYC 170 Query: 119 HSHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 HS ++HRD+KP N++I+ E ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 171 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDY 229 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM--- 233 + Y ++D+WSLGC+ A M+ R+ F G DQL RI + LGT D + ++ Sbjct: 230 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 289 Query: 234 PDYKPSFPKWARQDFSKVVPPLDE-----DGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 P + + +R+ + + V ++ + L ++L YD R++A+ A+ HP+F Sbjct: 290 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 349 Query: 289 VTK 291 V K Sbjct: 350 VVK 352 >4UZD-A nrPDB Length = 287 Score = 127 bits (320), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 87/299 (29%), Positives = 149/299 (49%), Gaps = 45/299 (15%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59 +E+F+ +G+G +G VY AR K + ++ALK + + E GV RE+ + L Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 66 Query: 60 HPNIVKLLDVIHTENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 HPNI++L H ++YL+ E+ ++++L+K L+ +Y+ +L Sbjct: 67 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQK------LSKFDEQRTATYITELANA 120 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 L++CHS RV+HRD+KP+NLL+ + G +K+ADFG + P T TL Y PE++ Sbjct: 121 LSYCHSKRVIHRDIKPENLLLGSAGELKIADFGW--SVHAPSSRRTTLCGTLDYLPPEMI 178 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 G + + VD+WSLG + E + + F ++ + RI R T P Sbjct: 179 EG-RMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFT-----------FP 226 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-QDVTKP 292 D+ + E R L+S++L ++P++R + L HP+ + +KP Sbjct: 227 DF------------------VTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKP 267 >4MD7-E nrPDB Length = 391 Score = 127 bits (319), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 89/303 (29%), Positives = 155/303 (51%), Gaps = 23/303 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +++Q V K+G G Y V++A N E V +K ++ + L P Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGP 92 Query: 62 NIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 NI+ L D++ LVFE ++ D K+ LT I+ Y++++L+ L +C Sbjct: 93 NIITLADIVKDPVSRTPALVFEHVNNTDFKQLY--QTLTDYD---IRFYMYEILKALDYC 147 Query: 119 HSHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 HS ++HRD+KP N++I+ E ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVDY 206 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM--- 233 + Y ++D+WSLGC+ A M+ R+ F G DQL RI + LGT D + ++ Sbjct: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Query: 234 PDYKPSFPKWARQDFSKVVPPLDE-----DGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 P + + +R+ + + V ++ + L ++L YD R++A+ A+ HP+F Sbjct: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 Query: 289 VTK 291 V K Sbjct: 327 VVK 329 >6FD3-A nrPDB Length = 300 Score = 124 bits (310), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 92/293 (31%), Positives = 144/293 (49%), Gaps = 32/293 (10%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 + + EKIG+G G VY A + TG+ VA+K++ L + + I EI +++E +PNI Sbjct: 24 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNPNI 81 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 V LD ++L++V E+L D T + I + + LQ L F HS++V Sbjct: 82 VNYLDSYLVGDELWVVMEYLAGG--SLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQV 139 Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 +HRD+K N+L+ +G++KL DFG + V T ++ APE++ K Y Sbjct: 140 IHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR-KAYGPK 198 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW 243 VDIWSLG + EMV + ++ + L+ + T GTP E+ P Sbjct: 199 VDIWSLGIMAIEMVEGEPPYLNENPLRALY-LIATNGTP-ELQNP--------------- 241 Query: 244 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296 + S V R L++ L D ++R SAK L HPF + + KP+ L Sbjct: 242 --ERLSAVF-------RDFLNRCLEMDVDRRGSAKELLQHPFLK-LDKPLSSL 284 >3MA6-A nrPDB Length = 298 Score = 124 bits (310), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 87/294 (29%), Positives = 147/294 (50%), Gaps = 49/294 (16%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 +G+G++G V ++K+TG+ A+K I + + + + +RE+ LLK+L+HPNI+KL + Sbjct: 40 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYE 99 Query: 69 VIHTENKLYLVFEF-----LHQDL---KKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 + YLV E L ++ K+F + A I Q+L G+ + H Sbjct: 100 FFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIR---------QVLSGITYMHK 150 Query: 121 HRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 ++++HRDLKP+NLL+ + + I++ DFGL+ F + ++ T +Y APE+L G Sbjct: 151 NKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEAS-KKMKDKIGTAYYIAPEVLHGT 209 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 Y D+WS G I +++ F G +E D L ++ + Y Sbjct: 210 --YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK----------------GKYT 251 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 P+W + + E + L+ +ML Y P+ RISA+ AL H + Q TK Sbjct: 252 FELPQWKK---------VSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTK 296 >2QNJ-A nrPDB Length = 328 Score = 123 bits (309), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 79/218 (36%), Positives = 121/218 (55%), Gaps = 8/218 (3%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTA---IREISLLKELN 59 N++ ++ IG+G + V AR+ LTG VA+K I +T+ P++ RE+ ++K LN Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILTGREVAIKII---DKTQLNPTSLQKLFREVRIMKILN 69 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 HPNIVKL +VI TE LYL+ E+ + F A + +S Q++ + +CH Sbjct: 70 HPNIVKLFEVIETEKTLYLIMEYASGG-EVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 128 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 R++HRDLK +NLL++ + IK+ADFG + F V + T + Y APE+ G KY Sbjct: 129 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTF-CGSPPYAAPELFQGKKY 187 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR 217 VD+WSLG I +V+ F G + + R+ R Sbjct: 188 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 225 >6O6Q-A nrPDB Length = 335 Score = 123 bits (308), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 88/302 (29%), Positives = 159/302 (52%), Gaps = 32/302 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKEL-N 59 EN++ + K+G G Y V+ + E V +K ++ V I REIS+LK L + Sbjct: 41 ENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLK------PVKRKKIKREISILKNLVD 94 Query: 60 HPNIVKLLDVIHTENKLY--LVFEFLHQDLKKFMDASALTGIPLPL-IKSYLFQLLQGLA 116 PNI+ +LDV+ L+FE ++ +D +L I+ Y+++LL+ L Sbjct: 95 GPNIIAMLDVVREPQSKTPGLIFEHINN-----IDFRSLYPTFTDYDIRFYMYELLKALD 149 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAI-KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 + HS ++HRD+KP N++I+ + + +L D+GLA + P Y V + +++ PE+L+ Sbjct: 150 YSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYH-PGTEYNVRVASRYFKGPELLV 208 Query: 176 GCKYYSTAVDIWSLGCIFAEMV-TRRALFPGDSEIDQLFRIFRTLGTPD--EVVWPGVTS 232 + Y ++D+WS GC+ A MV + F G S DQL +I R LG+ + + + S Sbjct: 209 DYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNIS 268 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQ--------MLHYDPNKRISAKAALAHP 284 + + + ++ + + ++E+ + L+SQ +L YD +R++AK A+ H Sbjct: 269 LGEEYEDIGYYNKRQWVRF---MNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHA 325 Query: 285 FF 286 +F Sbjct: 326 YF 327 >5JN2-A nrPDB Length = 525 Score = 123 bits (308), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 87/298 (29%), Positives = 150/298 (50%), Gaps = 57/298 (19%) Query: 10 IGEGTYGVVYKARNKLTGE-----VVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64 +G+G++G V ++K+TG+ V++ ++++ T+ E + +RE+ LLK+L+HPNI+ Sbjct: 75 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESL----LREVQLLKQLDHPNIM 130 Query: 65 KLLDVIHTENKLYLVFE-FLHQDL-------KKFMDASALTGIPLPLIKSYLFQLLQGLA 116 KL + + YLV E + +L K+F + A I Q+L G+ Sbjct: 131 KLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIR---------QVLSGIT 181 Query: 117 FCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 173 + H ++++HRDLKP+NLL+ + + I++ DFGL+ F + ++ T +Y APE+ Sbjct: 182 YMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEAS-KKMKDKIGTAYYIAPEV 240 Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233 L G Y D+WS G I +++ F G +E D L ++ + Sbjct: 241 LHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK---------------- 282 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 Y P+W + + E + L+ +ML Y P+ RISA+ AL H + Q TK Sbjct: 283 GKYTFELPQWKK---------VSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTK 331 >2WO6-A nrPDB Length = 382 Score = 122 bits (307), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 96/332 (28%), Positives = 151/332 (45%), Gaps = 52/332 (15%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 M+ ++ IG+G++G V KA +++ E VA+K I+ + + A E+ LL+ +N Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIK---NKKAFLNQAQIEVRLLELMNK 109 Query: 61 PNIVKLLDVIHTE------NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 + ++H + N L LVFE L +L + + G+ L L + + Q+ Sbjct: 110 HDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTA 169 Query: 115 LAFCHSHR--VLHRDLKPQNLLINT--EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 L F + ++H DLKP+N+L+ AIK+ DFG + G + Y + + +YR+ Sbjct: 170 LLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQY---IQSRFYRS 226 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 PE+LLG Y A+D+WSLGCI EM T LF G +E+DQ+ +I LG P + Sbjct: 227 PEVLLGMPY-DLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQA 285 Query: 231 TSMPDYKPSFP------KWARQDFSKVVPP--------------------LDEDG----- 259 + P K + + PP E G Sbjct: 286 PKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVAD 345 Query: 260 ----RSLLSQMLHYDPNKRISAKAALAHPFFQ 287 + L+ +ML YDP RI AL H FF+ Sbjct: 346 YLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 377 >3D2K-A nrPDB Length = 272 Score = 122 bits (307), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 85/299 (28%), Positives = 147/299 (49%), Gaps = 45/299 (15%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59 +E+F +G+G +G VY AR + + ++ALK + + E GV RE+ + L Sbjct: 11 LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLR 70 Query: 60 HPNIVKLLDVIHTENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 HPNI++L H ++YL+ E+ ++++L+K L+ +Y+ +L Sbjct: 71 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQK------LSRFDEQRTATYITELANA 124 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 L++CHS RV+HRD+KP+NLL+ + G +K+ADFG + P T TL Y PE++ Sbjct: 125 LSYCHSKRVIHRDIKPENLLLGSNGELKIADFGW--SVHAPSSRRTTLCGTLDYLPPEMI 182 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 G + + VD+WSLG + E + F + + RI R T P Sbjct: 183 EG-RMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFT-----------FP 230 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ-DVTKP 292 D+ + E R L+S++L ++ ++R++ L HP+ + + +KP Sbjct: 231 DF------------------VTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKP 271 >5ES1-A nrPDB Length = 328 Score = 122 bits (307), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 80/219 (36%), Positives = 119/219 (54%), Gaps = 10/219 (4%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTA---IREISLLKELN 59 N++ + IG+G + V AR+ LTG VA+K I +T+ PS+ RE+ ++K LN Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKII---DKTQLNPSSLQKLFREVRIMKGLN 72 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFC 118 HPNIVKL +VI TE LYLV E+ + D G + ++ Q++ + +C Sbjct: 73 HPNIVKLFEVIETEKTLYLVMEYASAG--EVFDYLVSHGRMKEKEARAKFRQIVSAVHYC 130 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 H ++HRDLK +NLL++ E IK+ADFG + F + + T + Y APE+ G K Sbjct: 131 HQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTF-CGSPPYAAPELFQGKK 189 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR 217 Y VDIWSLG I +V+ F G + + R+ R Sbjct: 190 YDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLR 228 >4D28-A nrPDB Length = 446 Score = 122 bits (305), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 75/186 (40%), Positives = 106/186 (56%), Gaps = 4/186 (2%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELNHPNIVKLLD 68 IGEGT+ V ARN TG+ VA+K + T + I REIS++K + HPNIV+L + Sbjct: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 Query: 69 VIHTENKLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 V+ +++K+Y+V EF+ + D G + + Y QL+ +A CHS V HRD Sbjct: 77 VLASKSKIYIVLEFVTGG--ELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHSKGVYHRD 134 Query: 128 LKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIW 187 LKP+NLL++T G +K++DFGL+ V T Y APE+L G Y +A DIW Sbjct: 135 LKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYDGSAADIW 194 Query: 188 SLGCIF 193 S G I Sbjct: 195 SCGVIL 200 >6HXF-B nrPDB Length = 302 Score = 122 bits (305), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 92/294 (31%), Positives = 141/294 (47%), Gaps = 34/294 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E ++ V ++G+G +G VYKA+NK TG + A K I +T++E I EI +L +HP Sbjct: 19 EVWEIVGELGDGAFGKVYKAKNKETGALAAAKVI--ETKSEEELEDYIVEIEILATCDHP 76 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 IVKLL + + KL+++ EF + G+ P I+ Q+L+ L F HS Sbjct: 77 YIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSK 136 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY-- 179 R++HRDLK N+L+ EG I+LADFG++ ++ + T ++ APE+++ C+ Sbjct: 137 RIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVM-CETMK 195 Query: 180 ---YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 Y DIWSLG EM + P E++ + R+ + D P P Sbjct: 196 DTPYDYKADIWSLGITLIEMAQ---IEPPHHELNPM-RVLLKIAKSD----PPTLLTPS- 246 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 KW+ + R L L +P R SA L HPF +T Sbjct: 247 -----KWSVE------------FRDFLKIALDKNPETRPSAAQLLEHPFVSSIT 283 >5KZ7-A nrPDB Length = 346 Score = 121 bits (303), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 76/219 (34%), Positives = 117/219 (53%), Gaps = 10/219 (4%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 N++ ++ IG+G + V AR+ LTG+ VA+K I RE+ ++K LNHPN Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 93 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 IVKL +VI TE LYLV E+ + F A + ++ Q++ + +CH Sbjct: 94 IVKLFEVIETEKTLYLVMEYASGG-EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 152 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW----YRAPEILLGCK 178 ++HRDLK +NLL++ + IK+ADFG + F T+ +++ T Y APE+ G K Sbjct: 153 IVHRDLKAENLLLDADMNIKIADFGFSNEF-----TFGNKLDTFCGSPPYAAPELFQGKK 207 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR 217 Y VD+WSLG I +V+ F G + + R+ R Sbjct: 208 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 246 >3Q53-A nrPDB Length = 306 Score = 120 bits (301), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 88/293 (30%), Positives = 142/293 (48%), Gaps = 32/293 (10%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 + + EKIG+G G VY A + TG+ VA++++ L + + I EI +++E +PNI Sbjct: 23 YTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPK--KELIINEILVMRENKNPNI 80 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 V LD ++L++V E+L D T + I + + LQ L F HS++V Sbjct: 81 VNYLDSYLVGDELWVVMEYLAGG--SLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQV 138 Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 +HRD+K N+L+ +G++KL DFG + V T ++ APE++ K Y Sbjct: 139 IHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR-KAYGPK 197 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW 243 VDIWSLG + EM+ + ++ + L+ + T GTP E+ P Sbjct: 198 VDIWSLGIMAIEMIEGEPPYLNENPLRALY-LIATNGTP-ELQNP--------------- 240 Query: 244 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296 + S + R L++ L D KR SAK + H F + + KP+ L Sbjct: 241 --EKLSAIF-------RDFLNRCLEMDVEKRGSAKELIQHQFLK-IAKPLSSL 283 >3MN3-A nrPDB Length = 271 Score = 120 bits (300), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 87/288 (30%), Positives = 141/288 (48%), Gaps = 37/288 (12%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELNHP 61 N+Q V+ +GEG++G V A + TG+ VALK I + I REIS L+ L HP Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +I+KL DVI +++++ +V E+ +L ++ + + + Q++ + +CH H Sbjct: 65 HIIKLYDVIKSKDEIIMVIEYAGNELFDYI--VQRDKMSEQEARRFFQQIISAVEYCHRH 122 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKY 179 +++HRDLKP+NLL++ +K+ADFGL+ G ++T + Y APE++ G Y Sbjct: 123 KIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKT---SCGSPNYAAPEVISGKLY 179 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 VD+WS G I M+ RR F D I LF+ GV ++P + Sbjct: 180 AGPEVDVWSCGVILYVMLCRRLPF-DDESIPVLFKNISN----------GVYTLPKF--- 225 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 L L+ +ML +P RIS + +F+ Sbjct: 226 ---------------LSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK 258 >6FDY-U nrPDB Length = 276 Score = 119 bits (298), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 89/291 (30%), Positives = 140/291 (48%), Gaps = 38/291 (13%) Query: 1 MENFQKVEKIGEGTYGVVYKA-RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 ++ F E++G GTY VYKA K T EVVA+K + + + + EI +LK + Sbjct: 10 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIR 69 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HP+IV+L D + +YL+ EF DL +F+ + +P + + ++ QL L F Sbjct: 70 HPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRI--LPEKVARVFMQQLASALQFL 127 Query: 119 HSHRVLHRDLKPQNLLINT--EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 H + H DLKPQN+L+++ + +KLADFG A+ + L Y APE++ Sbjct: 128 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL-YMAPEMVCQ 186 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGD--SEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 + Y VD+WS+G I E + + F SE+++ R R + P Sbjct: 187 -RQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELP------------ 233 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 + P L D R LL ++L DP++RIS + AHP+ Sbjct: 234 ----------------LRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPW 268 >4LG4-A nrPDB Length = 299 Score = 118 bits (296), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 90/302 (29%), Positives = 150/302 (49%), Gaps = 44/302 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E F +EK+GEG+YG V+KA +K +G+VVA+K++ ++++ + + I+EIS++++ + P Sbjct: 11 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI----IKEISIMQQCDSP 66 Query: 62 NIVKLLDVIHTENKLYLVFEFLH----QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 +VK L++V E+ D+ + + + + ++KS L+GL + Sbjct: 67 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKS----TLKGLEY 122 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 H R +HR++K N+L+NTEG KLADFG+A + + T ++ APE++ Sbjct: 123 LHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 182 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 Y A DIWSLG EM + P ++I + IF P Sbjct: 183 GYNCVA-DIWSLGITSIEMAEGK---PPYADIHPMRAIFMIPTNP--------------P 224 Query: 238 PSF--PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPH 295 P+F P+ DF+ V + L +P +R +A L HPF ++ KPV Sbjct: 225 PTFRKPELWSDDFTDFV-----------KKCLVKNPEQRATATQLLQHPFIKN-AKPVSI 272 Query: 296 LR 297 LR Sbjct: 273 LR 274 >2HAK-A nrPDB Length = 328 Score = 118 bits (296), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 78/218 (35%), Positives = 119/218 (54%), Gaps = 8/218 (3%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTA---IREISLLKELN 59 N++ + IG+G + V AR+ LTG VA+K I +T+ P++ RE+ ++K LN Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKII---DKTQLNPTSLQKLFREVRIMKILN 72 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 HPNIVKL +VI TE LYLV E+ + F A + ++ Q++ + +CH Sbjct: 73 HPNIVKLFEVIETEKTLYLVMEYASGG-EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 131 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 ++HRDLK +NLL++ + IK+ADFG + F V + T + Y APE+ G KY Sbjct: 132 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTF-CGSPPYAAPELFQGKKY 190 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR 217 VD+WSLG I +V+ F G + + R+ R Sbjct: 191 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 228 >5XZW-A nrPDB Length = 471 Score = 118 bits (296), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 90/301 (29%), Positives = 142/301 (47%), Gaps = 48/301 (15%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 E +G+G + V KA + TG+ A+K I + G RE+ +L++LNHP IV+L Sbjct: 202 EVVGQGAFATVKKAIERTTGKTFAVKIIS-KRKVIGNMDGVTRELEVLQKLNHPRIVRLK 260 Query: 68 DVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 Y+V EF+ DL F+ A G + Q+L + + HS + HR Sbjct: 261 GFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAG--REISRQILTAIKYIHSMGISHR 318 Query: 127 DLKPQNLLINTEG--AIKLADFGLAR--AFGVPVRTYTHEVVTLWYRAPEILLGC----- 177 DLKP N+LI + +K+ DFGLA+ G ++T+ TL Y APE++ G Sbjct: 319 DLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCG---TLAYVAPEVIRGKDTSVS 375 Query: 178 -------KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 YS+ VD+WS+GC+ ++T F G ++ DQL ++ +G Sbjct: 376 PDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQL---YKQIG---------- 421 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 + S+ + +DF + E+ R + +L DPN R +A AL HP+ D + Sbjct: 422 ------RGSYHEGPLKDFR-----ISEEARDFIDSLLQVDPNNRSTAAKALNHPWIVDSS 470 Query: 291 K 291 Sbjct: 471 N 471 >4APC-A nrPDB Length = 350 Score = 118 bits (295), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 77/286 (26%), Positives = 129/286 (45%), Gaps = 30/286 (10%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME + +++KIGEG++G ++ G +K+I + + + RE+++L + H Sbjct: 23 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 82 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 PNIV+ + LY+V ++ DL K ++A I + Q+ L H Sbjct: 83 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 142 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 ++LHRD+K QN+ + +G ++L DFG+AR V + T +Y +PEI K Sbjct: 143 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICEN-KP 201 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 Y+ DIW+LGC+ E+ T + F S + + +I +P V+ Y Sbjct: 202 YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISG-------SFPPVSLHYSY--- 251 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 D RSL+SQ+ +P R S + L F Sbjct: 252 ------------------DLRSLVSQLFKRNPRDRPSVNSILEKGF 279 >6AO5-A nrPDB Length = 362 Score = 118 bits (295), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 90/302 (29%), Positives = 150/302 (49%), Gaps = 44/302 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E F +EK+GEG+YG V+KA +K +G+VVA+K++ ++++ + + I+EIS++++ + P Sbjct: 10 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI----IKEISIMQQCDSP 65 Query: 62 NIVKLLDVIHTENKLYLVFEFLH----QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 +VK L++V E+ D+ + + + + ++KS L+GL + Sbjct: 66 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKS----TLKGLEY 121 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 H R +HR++K N+L+NTEG KLADFG+A + + T ++ APE++ Sbjct: 122 LHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 181 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 Y A DIWSLG EM + P ++I + IF P Sbjct: 182 GYNCVA-DIWSLGITSIEMAEGK---PPYADIHPMRAIFMIPTNP--------------P 223 Query: 238 PSF--PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPH 295 P+F P+ DF+ V + L +P +R +A L HPF ++ KPV Sbjct: 224 PTFRKPELWSDDFTDFV-----------KKCLVKNPEQRATATQLLQHPFIKN-AKPVSI 271 Query: 296 LR 297 LR Sbjct: 272 LR 273 >3COM-A nrPDB Length = 314 Score = 117 bits (293), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 88/291 (30%), Positives = 142/291 (48%), Gaps = 41/291 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E F +EK+GEG+YG VYKA +K TG++VA+K++ ++++ + + I+EIS++++ + P Sbjct: 29 EVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEI----IKEISIMQQCDSP 84 Query: 62 NIVKLLDVIHTENKLYLVFEFLH----QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 ++VK L++V E+ D+ + + + + I + L L+GL + Sbjct: 85 HVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT----LTEDEIATILQSTLKGLEY 140 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 H R +HRD+K N+L+NTEG KLADFG+A + + T ++ APE++ Sbjct: 141 LHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 200 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 Y A DIWSLG EM + P ++I + IF P Sbjct: 201 GYNCVA-DIWSLGITAIEMAEGK---PPYADIHPMRAIFMIPTNP--------------P 242 Query: 238 PSFPKWARQDFSKVVPPLDEDG-RSLLSQMLHYDPNKRISAKAALAHPFFQ 287 P+F K P L D + Q L P +R +A L HPF + Sbjct: 243 PTFRK----------PELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVR 283 >6C9D-A nrPDB Length = 459 Score = 117 bits (292), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 77/218 (35%), Positives = 118/218 (54%), Gaps = 8/218 (3%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTA---IREISLLKELN 59 N++ + IG+G + V AR+ LTG VA+K I +T+ P++ RE+ ++K LN Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKII---DKTQLNPTSLQKLFREVRIMKILN 78 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 HPNIVKL +VI TE LYLV E+ + F A + ++ Q++ + +CH Sbjct: 79 HPNIVKLFEVIETEKTLYLVMEYASGG-EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 137 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 ++HRDLK +NLL++ + IK+ADFG + F V + + Y APE+ G KY Sbjct: 138 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK-LDEFCGSPPYAAPELFQGKKY 196 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR 217 VD+WSLG I +V+ F G + + R+ R Sbjct: 197 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 234 >4LFI-A nrPDB Length = 374 Score = 116 bits (291), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 81/251 (32%), Positives = 133/251 (52%), Gaps = 27/251 (10%) Query: 60 HPNIVKLLDVIHT--ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 H NI+ L D+I LVFE++ + + LT + I+ Y+F+LL+ L + Sbjct: 132 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRIL-YPKLTDLE---IRFYMFELLKALDY 187 Query: 118 CHSHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 CHS ++HRD+KP N++I+ + ++L D+GLA + V + Y V + +++ PE+L+ Sbjct: 188 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVD 246 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEIDQLFRIFRTLGTPD--------EVVW 227 + Y ++D+WS G + A M+ +R F G S DQL +I + LGT D E+ Sbjct: 247 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 306 Query: 228 P-GVTSMPDY--KPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 282 P M Y KP W R D +K + DE L+ +L YD +R++AK A+ Sbjct: 307 PREFYDMDQYIRKP----WHRFINDGNKHLSGNDE-IIDLIDNLLRYDHQERLTAKEAMG 361 Query: 283 HPFFQDVTKPV 293 HP+F + + + Sbjct: 362 HPWFAPIREQI 372 >4YNZ-A nrPDB Length = 342 Score = 115 bits (288), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 90/284 (31%), Positives = 138/284 (48%), Gaps = 36/284 (12%) Query: 6 KVEK-IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64 ++EK +G+G G+V + +T + VA+K + + +E V REI++LK + HP+++ Sbjct: 13 RLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVL 72 Query: 65 KLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPL-IKSYLFQLLQGLAFCHSHRV 123 KL DV + LYLV E H + D G P + + Q++ L FCHSH + Sbjct: 73 KLHDVYENKKYLYLVLE--HVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSI 130 Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 HRDLKP+NLL++ I++ADFG+A + V + Y PE++ G KY Sbjct: 131 CHRDLKPENLLLDERNNIRIADFGMA-SLQVGDSLLETSCGSPHYACPEVIRGEKYDGRK 189 Query: 184 VDIWSLGCI-FAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPK 242 D+WS G I FA +V AL D + QL E V GV MP + Sbjct: 190 ADVWSCGVILFALLVG--ALPFDDDNLRQLL----------EKVKRGVFHMPHF------ 231 Query: 243 WARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 +PP D +SLL M+ D +R++ + H ++ Sbjct: 232 ---------IPP---DCQSLLRGMIEVDAARRLTLEHIQKHIWY 263 >5FG8-A nrPDB Length = 285 Score = 115 bits (287), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 91/287 (31%), Positives = 141/287 (49%), Gaps = 30/287 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +N+ E++G+G + +V + K TG A K I T RE + ++L+HP Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHP 73 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L D I EN YLVF+ + + F D A + Q+L+ + CH + Sbjct: 74 NIVRLHDSIQEENYHYLVFDLV-TGGELFEDIVAREFYSEADASHCIQQILESVNHCHQN 132 Query: 122 RVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 V+HRDLKP+NLL+ ++ A+KLADFGLA + + T Y +PE+L + Sbjct: 133 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKK-E 191 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y +VDIW+ G I ++ +P + DQ R++ + G P Sbjct: 192 PYGKSVDIWACGVILYILLVG---YPPFWDEDQ-HRLYSQIKA-------GAYDYPS--- 237 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 P+W V P + ++L++QML +PNKRI+A AL HP+ Sbjct: 238 --PEW-----DTVTP----EAKNLINQMLTVNPNKRITAAEALKHPW 273 >4B8L-A nrPDB Length = 286 Score = 115 bits (287), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 88/303 (29%), Positives = 145/303 (47%), Gaps = 52/303 (17%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59 +++F +G+G +G VY AR K ++ALK + + E EGV REI + L Sbjct: 14 IDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLR 73 Query: 60 HPNIVKLLDVIHTENKLYLVFEF-----LHQDLKK---FMDASALTGIPLPLIKSYLFQL 111 HPNI+++ + H ++YL+ EF L+++L+K F + + T ++ +L Sbjct: 74 HPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSAT---------FMEEL 124 Query: 112 LQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLA-RAFGVPVRTYTHEVVTLWYRA 170 L +CH +V+HRD+KP+NLL+ +G +K+ADFG + A + RT TL Y Sbjct: 125 ADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTM---CGTLDYLP 181 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 PE++ G K + VD+W G + E + F S + RI Sbjct: 182 PEMIEG-KTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNV------------ 228 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 D K FP P L + + L+S++L Y P +R+ K + HP+ + + Sbjct: 229 ----DLK--FP-----------PFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKANS 271 Query: 291 KPV 293 + V Sbjct: 272 RRV 274 >4IAN-A nrPDB Length = 358 Score = 114 bits (286), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 96/319 (30%), Positives = 149/319 (46%), Gaps = 48/319 (15%) Query: 11 GEGTYGVVYKAR-NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN------I 63 G+G + V +AR N + VA+K IR E + T ++E+ LK+LN + Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIR---NNELMQKTGLKELEFLKKLNDADPDDKFHC 95 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASAL-TGIPLPLIKSYLFQLLQGLAFCHSHR 122 ++L + + L LVFE L +L++ + G+ + ++SY QL L Sbjct: 96 LRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCN 155 Query: 123 VLHRDLKPQNLLINTEGAI-KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 +LH D+KP N+L+N I KL DFG A V T +V+ +YRAPEI++G K Y Sbjct: 156 ILHADIKPDNILVNESKTILKLCDFGSASH--VADNDITPYLVSRFYRAPEIIIG-KSYD 212 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTL--GTPDEVVWPGVTSMPDYKPS 239 +D+WS+GC E+ T + LFPG + + + ++ L P++++ GV + + Sbjct: 213 YGIDMWSVGCTLYELYTGKILFPGKTN-NHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQN 271 Query: 240 F-------PKWARQD----FSKVVPPLD------------EDGR-------SLLSQMLHY 269 K ++ S + P D ED R LL Q+L Sbjct: 272 LNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILML 331 Query: 270 DPNKRISAKAALAHPFFQD 288 DP KRIS AL H F Q+ Sbjct: 332 DPAKRISINQALQHAFIQE 350 >6CQF-A nrPDB Length = 297 Score = 114 bits (286), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 71/201 (35%), Positives = 114/201 (56%), Gaps = 11/201 (5%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +++ ++++G GTYG V+KAR+K++G++VALK ++++ + + ST +EI +LK H Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDD--VSTLQKEILILKTCRHA 73 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF-QLLQGLAFCHS 120 NIV KL++ EF D +TG L SY+ ++LQGLA+ HS Sbjct: 74 NIVAYHGSYLWLQKLWICMEFCGAG--SLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 131 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI----LLG 176 + +HRD+K N+LIN G ++LADFG++ G + + T ++ APE+ L G Sbjct: 132 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKG 191 Query: 177 CKYYSTAVDIWSLGCIFAEMV 197 Y+ DIWSLG E+ Sbjct: 192 G--YNELCDIWSLGITAIELA 210 >2UV2-A nrPDB Length = 325 Score = 114 bits (284), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 92/305 (30%), Positives = 147/305 (48%), Gaps = 47/305 (15%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 ++ + ++G+G +G VYKA+NK T + A K I DT++E + EI +L +HPNI Sbjct: 39 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVI--DTKSEEELEDYMVEIDILASCDHPNI 96 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF----QLLQGLAFCH 119 VKLLD + EN L+++ EF +DA L + PL +S + Q L L + H Sbjct: 97 VKLLDAFYYENNLWILIEFC---AGGAVDAVMLE-LERPLTESQIQVVCKQTLDALNYLH 152 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 ++++HRDLK N+L +G IKLADFG++ ++ + T ++ APE+++ C+ Sbjct: 153 DNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVM-CET 211 Query: 180 -----YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 Y D+WSLG EM + P E++ + R+ + + P + P Sbjct: 212 SKDRPYDYKADVWSLGITLIEMA---EIEPPHHELNPM-RVLLKIAKSE----PPTLAQP 263 Query: 235 DYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ-DVTK 291 +W+ +DF K + D R SQ+L HPF D K Sbjct: 264 ------SRWSSNFKDFLKKCLEKNVDARWTTSQLLQ--------------HPFVTVDSNK 303 Query: 292 PVPHL 296 P+ L Sbjct: 304 PIREL 308 >4PDS-A nrPDB Length = 347 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 88/300 (29%), Positives = 143/300 (47%), Gaps = 54/300 (18%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALK---KIRLDTETEGVPSTAIREISLLKELNHPNIV 64 E +G+G + V KA + TG+ ++K K ++ +GV RE+ +L++LNHP IV Sbjct: 37 EVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGV----TRELEVLQKLNHPRIV 92 Query: 65 KLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 +L Y+V EF+ DL F+ A G + Q+L + + HS + Sbjct: 93 RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAG--REISRQILTAIKYIHSMGI 150 Query: 124 LHRDLKPQNLLINTEGA--IKLADFGLAR--AFGVPVRTYTHEVVTLWYRAPEILLGC-- 177 HRDLKP N+LI + +K+ FGLA+ G ++T+ TL Y APE++ G Sbjct: 151 SHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCG---TLAYVAPEVIRGKDT 207 Query: 178 ----------KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227 YS+ VD+WS+GC+ ++T F G ++ DQL ++ +G Sbjct: 208 SVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQL---YKQIG------- 256 Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 + S+ + +DF + E+ R + +L DPN R +A AL HP+ + Sbjct: 257 ---------RGSYHEGPLKDFR-----ISEEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >2F57-A nrPDB Length = 317 Score = 112 bits (281), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 86/292 (29%), Positives = 137/292 (46%), Gaps = 34/292 (11%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 KIGEG+ G+V A K TG+ VA+KK +D + E+ ++++ +H N+V + Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKK--MDLRKQQRRELLFNEVVIMRDYHHDNVVDMYS 109 Query: 69 VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 128 ++L++V EFL + D T + I + +L+ L++ H+ V+HRD+ Sbjct: 110 SYLVGDELWVVMEFL--EGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDI 167 Query: 129 KPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWS 188 K ++L+ ++G IKL+DFG V V T ++ APE++ Y T VDIWS Sbjct: 168 KSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLP-YGTEVDIWS 226 Query: 189 LGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDF 248 LG + EM+ G P P + +M + S P + D Sbjct: 227 LGIMVIEMID---------------------GEPPYFNEPPLQAMRRIRDSLPPRVK-DL 264 Query: 249 SKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP---VPHLR 297 KV L R L ML +P++R +A+ L HPF + P VP +R Sbjct: 265 HKVSSVL----RGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMR 312 >4CQG-A nrPDB Length = 331 Score = 112 bits (280), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 89/297 (29%), Positives = 135/297 (45%), Gaps = 37/297 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ ++ E IG G + V A + LTGE+VA+K + + +P EI LK L H Sbjct: 8 LKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKT-EIDALKSLRH 66 Query: 61 PNIVKLLDVIHTENKLYLVFEFL--HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 +I +L V+ T+NK+++V E+ + + L+ ++ Q+L +A+ Sbjct: 67 QHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVV---FRQILSAVAYV 123 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGL-ARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 HS HRDLKP+NLL + +KL DFGL A+ G +L Y APE++ G Sbjct: 124 HSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGK 183 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 Y + D+WS+G + ++ F D+ + +I R K Sbjct: 184 SYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRG------------------K 225 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF-FQDVTKPV 293 PKW L LL QML DP KRIS + L HP+ QD + PV Sbjct: 226 YEVPKW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPV 271 >4RED-A nrPDB Length = 351 Score = 112 bits (279), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 93/289 (32%), Positives = 134/289 (46%), Gaps = 39/289 (13%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHPNIVKL 66 + +G GT+G V +++LTG VA+K + R + V REI LK HP+I+KL Sbjct: 20 DTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKL 79 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ-LLQGLAFCHSHRVLH 125 VI T + +++V E++ + D G LFQ +L G+ +CH H V+H Sbjct: 80 YQVISTPSDIFMVMEYVSG--GELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVH 137 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 RDLKP+N+L++ K+ADFGL+ G +RT + Y APE++ G Y Sbjct: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT---SCGSPNYAAPEVISGRLYAGPE 194 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW 243 VDIWS G I ++ F D + LF+ + G+ P Y Sbjct: 195 VDIWSSGVILYALLCGTLPF-DDDHVPTLFK----------KICDGIFYTPQY------- 236 Query: 244 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-QDVTK 291 L+ SLL ML DP KR S K H +F QD+ K Sbjct: 237 -----------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPK 274 >4JXF-A nrPDB Length = 266 Score = 111 bits (278), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 80/290 (27%), Positives = 138/290 (47%), Gaps = 35/290 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59 +E+F+ +G+G++ VY+A + TG VA+K I + G+ E+ + +L Sbjct: 6 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 65 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HP+I++L + N +YLV E H ++ +++ + + + ++ Q++ G+ + Sbjct: 66 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYL-KNRVKPFSENEARHFMHQIITGMLYL 124 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 HSH +LHRDL NLL+ IK+ADFGLA +P + T Y +PEI Sbjct: 125 HSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSA 184 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK- 237 + D+WSLGC+F ++ R F D+ + L ++ + DY+ Sbjct: 185 -HGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV----------------LADYEM 227 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 PSF L + + L+ Q+L +P R+S + L HPF Sbjct: 228 PSF--------------LSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263 >6CMJ-A nrPDB Length = 321 Score = 111 bits (278), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 84/298 (28%), Positives = 144/298 (48%), Gaps = 42/298 (14%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALK---KIRLDTETEGV--PSTAI----RE 51 ++ + ++IG+G+YGVV A N+ A+K K +L + G P I +E Sbjct: 33 LDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQE 92 Query: 52 ISLLKELNHPNIVKLLDVIH--TENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF 109 I++LK+L+HPN+VKL++V+ E+ LY+VFE ++Q M+ L + + Y Sbjct: 93 IAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQ--GPVMEVPTLKPLSEDQARFYFQ 150 Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYR 169 L++G+ + H +++HRD+KP NLL+ +G IK+ADFG++ F ++ V T + Sbjct: 151 DLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFM 210 Query: 170 APEILLGCK--YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227 APE L + + A+D+W++G V + F DE + Sbjct: 211 APESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF------------------MDERIM 252 Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 + + FP P + ED + L+++ML +P RI HP+ Sbjct: 253 CLHSKIKSQALEFPDQ---------PDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 301 >4REW-A nrPDB Length = 540 Score = 111 bits (278), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 93/289 (32%), Positives = 134/289 (46%), Gaps = 39/289 (13%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHPNIVKL 66 + +G GT+G V +++LTG VA+K + R + V REI LK HP+I+KL Sbjct: 12 DTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKL 71 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ-LLQGLAFCHSHRVLH 125 VI T + +++V E++ + D G LFQ +L G+ +CH H V+H Sbjct: 72 YQVISTPSDIFMVMEYVSG--GELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVH 129 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 RDLKP+N+L++ K+ADFGL+ G +RT + Y APE++ G Y Sbjct: 130 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT---SCGSPNYAAPEVISGRLYAGPE 186 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW 243 VDIWS G I ++ F D + LF+ + G+ P Y Sbjct: 187 VDIWSSGVILYALLCGTLPF-DDDHVPTLFK----------KICDGIFYTPQY------- 228 Query: 244 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-QDVTK 291 L+ SLL ML DP KR S K H +F QD+ K Sbjct: 229 -----------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPK 266 >2WTK-C nrPDB Length = 305 Score = 111 bits (277), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 83/292 (28%), Positives = 137/292 (46%), Gaps = 38/292 (13%) Query: 10 IGEGTYGVVYKARNK--LTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 +GEG+YG V + + L V + K + + +EI LL+ L H N+++L+ Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLV 72 Query: 68 DVIHTE--NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 125 DV++ E K+Y+V E+ +++ +D+ P+ Y QL+ GL + HS ++H Sbjct: 73 DVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVH 132 Query: 126 RDLKPQNLLINTEGAIKLADFGLARA---FGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182 +D+KP NLL+ T G +K++ G+A A F T + + ++ PEI G +S Sbjct: 133 KDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQ-GSPAFQPPEIANGLDTFSG 191 Query: 183 -AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 VDIWS G + T L+P E D ++++F +G G ++P Sbjct: 192 FKVDIWSAGVTLYNITT--GLYP--FEGDNIYKLFENIGK-------GSYAIP------- 233 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293 PPL + LL ML Y+P KR S + H +F+ P Sbjct: 234 -------GDCGPPLSD----LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPA 274 >3Q5I-A nrPDB Length = 504 Score = 111 bits (277), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 85/296 (28%), Positives = 136/296 (45%), Gaps = 47/296 (15%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR----------- 50 E++ KV K+G G YG V + K A+K I+ +G S + Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95 Query: 51 EISLLKELNHPNIVKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYL 108 EISLLK L+HPNI+KL DV + YLV EF + ++ ++ I + Sbjct: 96 EISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANI---M 152 Query: 109 FQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA---IKLADFGLARAFGVPVRTYTHEVVT 165 Q+L G+ + H H ++HRD+KP+N+L+ + + IK+ DFGL+ F + + T Sbjct: 153 KQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKL-RDRLGT 211 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEV 225 +Y APE+L K Y+ D+WS G I ++ F G ++ D + ++ + Sbjct: 212 AYYIAPEVLK--KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEK-------- 261 Query: 226 VWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281 Y F W + ++ + L+ ML YD NKR +A+ AL Sbjct: 262 --------GKYYFDFNDW---------KNISDEAKELIKLMLTYDYNKRCTAEEAL 300 >3TXO-A nrPDB Length = 353 Score = 110 bits (276), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 90/308 (29%), Positives = 144/308 (46%), Gaps = 61/308 (19%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLKEL 58 ++NF+ + +G+G++G V AR K TG++ A+K ++ D + + V T + L Sbjct: 22 IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR 81 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYLFQ 110 NHP + +L T ++L+ V EF++ Q ++F +A A + Y + Sbjct: 82 NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARA---------RFYAAE 132 Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLAR---AFGVPVRTYTHEVVTLW 167 ++ L F H +++RDLK N+L++ EG KLADFG+ + GV T+ T Sbjct: 133 IISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCG---TPD 189 Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227 Y APEIL Y AVD W++G + EM+ A F ++E D LF DEVV Sbjct: 190 YIAPEILQE-MLYGPAVDWWAMGVLLYEMLCGHAPFEAENE-DDLFEAILN----DEVV- 242 Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA------KAAL 281 +P W L ED +L + +P R+ + A L Sbjct: 243 ------------YPTW-----------LHEDATGILKSFMTKNPTMRLGSLTQGGEHAIL 279 Query: 282 AHPFFQDV 289 HPFF+++ Sbjct: 280 RHPFFKEI 287 >4D2V-A nrPDB Length = 356 Score = 110 bits (276), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 90/290 (31%), Positives = 129/290 (44%), Gaps = 37/290 (12%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 E IG G + V A + LTGE+VA+K + +T +P EI LK L H +I +L Sbjct: 35 ETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKT-EIEALKNLRHQHICQLY 93 Query: 68 DVIHTENKLYLVFEFL--HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 125 V+ T NK+++V E+ + + L+ ++ Q++ +A+ HS H Sbjct: 94 HVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVV---FRQIVSAVAYVHSQGYAH 150 Query: 126 RDLKPQNLLINTEGAIKLADFGL-ARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAV 184 RDLKP+NLL + +KL DFGL A+ G L Y APE++ G Y + Sbjct: 151 RDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYLGSEA 210 Query: 185 DIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWA 244 D+WS+G + ++ F D+ + +I R K PKW Sbjct: 211 DVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRG------------------KYDVPKW- 251 Query: 245 RQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF-FQDVTKPV 293 L LL QML DP KRIS K L HP+ QD PV Sbjct: 252 ----------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPV 291 >4KS7-A nrPDB Length = 292 Score = 110 bits (276), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 87/293 (29%), Positives = 137/293 (46%), Gaps = 34/293 (11%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 KIGEG+ G+V AR K +G VA+K +D + E+ ++++ H N+V++ Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKM--MDLRKQQRRELLFNEVVIMRDYQHFNVVEMYK 87 Query: 69 VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 128 +L+++ EFL D + + I + +LQ LA+ H+ V+HRD+ Sbjct: 88 SYLVGEELWVLMEFLQGG--ALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDI 145 Query: 129 KPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWS 188 K ++L+ +G +KL+DFG V V T ++ APE+ + Y+T VDIWS Sbjct: 146 KSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEV-ISRSLYATEVDIWS 204 Query: 189 LGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDF 248 LG + EMV + DS + + R + D P PK ++ Sbjct: 205 LGIMVIEMVDGEPPYFSDSPVQAMKR------------------LRDSPP--PKL--KNS 242 Query: 249 SKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP---VPHLRL 298 KV P L R L +ML DP +R +A+ L HPF P VP ++L Sbjct: 243 HKVSPVL----RDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQL 291 >4CFH-A nrPDB Length = 493 Score = 110 bits (275), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 92/289 (31%), Positives = 134/289 (46%), Gaps = 39/289 (13%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHPNIVKL 66 + +G GT+G V +++LTG VA+K + R + V REI LK HP+I+KL Sbjct: 39 DTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKL 98 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ-LLQGLAFCHSHRVLH 125 VI T + +++V E++ + D G LFQ +L G+ +CH H V+H Sbjct: 99 YQVISTPSDIFMVMEYVSGG--ELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVH 156 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 RDLKP+N+L++ K+ADFGL+ G +RT + Y APE++ G Y Sbjct: 157 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT---SCGSPNYAAPEVISGRLYAGPE 213 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW 243 VDIWS G I ++ F D + LF+ + G+ P Y Sbjct: 214 VDIWSSGVILYALLCGTLPF-DDDHVPTLFK----------KICDGIFYTPQY------- 255 Query: 244 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-QDVTK 291 L+ SLL ML DP KR + K H +F QD+ K Sbjct: 256 -----------LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK 293 >3H4J-B nrPDB Length = 336 Score = 110 bits (275), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 88/285 (30%), Positives = 139/285 (48%), Gaps = 41/285 (14%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHPNIVKL 66 E +GEG++G V A + T + VALK I R + + REIS LK L HP+I+KL Sbjct: 15 ETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKL 74 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFM-DASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 125 DVI T + +V E+ +L ++ + +T + + Q++ + +CH H+++H Sbjct: 75 YDVITTPTDIVMVIEYAGGELFDYIVEKKRMTEDEG---RRFFQQIICAIEYCHRHKIVH 131 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 RDLKP+NLL++ +K+ADFGL+ G ++T + Y APE++ G Y Sbjct: 132 RDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKT---SCGSPNYAAPEVINGKLYAGPE 188 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSE-IDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPK 242 VD+WS G + M+ R P D E I LF+ + V MPD+ Sbjct: 189 VDVWSCGIVLYVMLVGR--LPFDDEFIPNLFKKVNSC----------VYVMPDF------ 230 Query: 243 WARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 L +SL+ +M+ DP +RI+ + P+F Sbjct: 231 ------------LSPGAQSLIRRMIVADPMQRITIQEIRRDPWFN 263 >2BRG-A nrPDB Length = 297 Score = 110 bits (275), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 66/200 (33%), Positives = 104/200 (52%), Gaps = 4/200 (2%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 +E++ V+ +GEG YG V A N++T E VA+K + + + P +EI + K LNH Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD-CPENIKKEICINKMLNH 64 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 N+VK N YL E+ + F G+P P + + QL+ G+ + H Sbjct: 65 ENVVKFYGHRREGNIQYLFLEYCSGG-ELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCK 178 + HRD+KP+NLL++ +K++DFGLA F R TL Y APE+L + Sbjct: 124 IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRRE 183 Query: 179 YYSTAVDIWSLGCIFAEMVT 198 +++ VD+WS G + M+ Sbjct: 184 FHAEPVDVWSCGIVLTAMLA 203 >4CFF-A nrPDB Length = 571 Score = 110 bits (274), Expect = 9e-25, Method: Compositional matrix adjust. Identities = 89/284 (31%), Positives = 130/284 (45%), Gaps = 38/284 (13%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHPNIVKL 66 + +G GT+G V ++LTG VA+K + R + V REI LK HP+I+KL Sbjct: 39 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 98 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ-LLQGLAFCHSHRVLH 125 VI T ++V E++ + D G + LFQ +L + +CH H V+H Sbjct: 99 YQVISTPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVH 156 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 RDLKP+N+L++ K+ADFGL+ G +RT + Y APE++ G Y Sbjct: 157 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT---SCGSPNYAAPEVISGRLYAGPE 213 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW 243 VDIWS G I ++ F D + LF+ R GV +P+Y Sbjct: 214 VDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRG----------GVFYIPEY------- 255 Query: 244 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 L+ +LL ML DP KR + K H +F+ Sbjct: 256 -----------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 288 >5EZV-A nrPDB Length = 560 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 89/284 (31%), Positives = 130/284 (45%), Gaps = 38/284 (13%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHPNIVKL 66 + +G GT+G V ++LTG VA+K + R + V REI LK HP+I+KL Sbjct: 34 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 93 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ-LLQGLAFCHSHRVLH 125 VI T ++V E++ + D G + LFQ +L + +CH H V+H Sbjct: 94 YQVISTPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVH 151 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 RDLKP+N+L++ K+ADFGL+ G +RT + Y APE++ G Y Sbjct: 152 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT---SCGSPNYAAPEVISGRLYAGPE 208 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW 243 VDIWS G I ++ F D + LF+ R GV +P+Y Sbjct: 209 VDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRG----------GVFYIPEY------- 250 Query: 244 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 L+ +LL ML DP KR + K H +F+ Sbjct: 251 -----------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 283 >4RGJ-A nrPDB Length = 520 Score = 109 bits (273), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 91/320 (28%), Positives = 153/320 (47%), Gaps = 64/320 (20%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTG-----EVVALKKIRLDTETEGVPSTAIREISLLK 56 E ++ ++ +G+G++G V +R+K TG +V++ K ++ T+ E + +RE+ LLK Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESL----LREVELLK 115 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEF-----LHQDL---KKFMDASALTGIPLPLIKSYL 108 L+H NI+KL + N YLV + L ++ K+F + A I Sbjct: 116 MLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIK-------- 167 Query: 109 FQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTHEVV 164 Q+L G+ + H + V+HRDLKP+N+L+ T+ IK+ DFGL+ F + ++ Sbjct: 168 -QILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYS-KKMKDKIG 225 Query: 165 TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDE 224 T +Y AP++L G Y DIWS G I +++ F G +E D L ++ T D Sbjct: 226 TAYYIAPDVLHGT--YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFD- 282 Query: 225 VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284 +P +K + + + L+ +ML Y RISA+ AL H Sbjct: 283 --------LPQFK----------------KISDKAKDLIKKMLMYTSAVRISARDALEHE 318 Query: 285 FFQDVTKP------VPHLRL 298 + + +T +P L L Sbjct: 319 WIKMMTSKDNLNIDIPSLEL 338 >4CZT-A nrPDB Length = 464 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 74/213 (34%), Positives = 115/213 (53%), Gaps = 8/213 (3%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELNHPNIVKLLD 68 +GEGT+ V ARN G+ VA+K I + + I REIS +K + HPN++++ + Sbjct: 19 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 78 Query: 69 VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 128 V+ ++ K+Y V EF+ + F S+ + + Y QL+ + +CHS V HRDL Sbjct: 79 VMASKTKIYFVLEFVTGG-ELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDL 137 Query: 129 KPQNLLINTEGAIKLADFGLARAFGVPVRT--YTHEVV-TLWYRAPEILLGCKYYSTAVD 185 KP+NLL++ GA+K++DFGL+ A VR H T Y APE++ Y D Sbjct: 138 KPENLLLDANGALKVSDFGLS-ALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKAD 196 Query: 186 IWSLGCIFAEMVTRRALFPGDSEIDQLF-RIFR 217 +WS G I ++ F DS + L+ +IF+ Sbjct: 197 LWSCGVILFVLMAGYLPFE-DSNLTSLYKKIFK 228 >2XNP-A nrPDB Length = 279 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 73/213 (34%), Positives = 105/213 (49%), Gaps = 14/213 (6%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E+++ + IG G+YG K R K G+++ K++ + TE + E++LL+EL HP Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 62 NIVKLLDVI--HTENKLYLVFEFLH-QDLKKFMDASALTGIPL--PLIKSYLFQLLQGLA 116 NIV+ D I T LY+V E+ DL + L + + QL L Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125 Query: 117 FCH-----SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAP 171 CH H VLHRDLKP N+ ++ + +KL DFGLAR V T +Y +P Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFP 204 E + Y+ DIWSLGC+ E+ AL P Sbjct: 186 E-QMNRMSYNEKSDIWSLGCLLYELC---ALMP 214 >5F9E-A nrPDB Length = 353 Score = 108 bits (269), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 80/294 (27%), Positives = 140/294 (47%), Gaps = 36/294 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLKEL 58 +E+F+ + +G+G++G V+ A K T + A+K ++ D + V T + + L Sbjct: 18 IEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAW 77 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 HP + + T+ L+ V E+L+ DL + L Y +++ GL F Sbjct: 78 EHPFLTHMFCTFQTKENLFFVMEYLNGGDL--MYHIQSCHKFDLSRATFYAAEIILGLQF 135 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 HS +++RDLK N+L++ +G IK+ADFG+ + + T Y APEILLG Sbjct: 136 LHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQ 195 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 K Y+ +VD WS G + EM+ ++ F G E ++LF R Sbjct: 196 K-YNHSVDWWSFGVLLYEMLIGQSPFHGQDE-EELFHSIRM-----------------DN 236 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL-AHPFFQDVT 290 P +P+W L+++ + LL ++ +P KR+ + + HP F+++ Sbjct: 237 PFYPRW-----------LEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREIN 279 >2YZA-A nrPDB Length = 276 Score = 107 bits (268), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 88/284 (30%), Positives = 129/284 (45%), Gaps = 38/284 (13%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHPNIVKL 66 + +G GT+G V ++LTG VA+K + R + V REI LK HP+I+KL Sbjct: 17 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 76 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ-LLQGLAFCHSHRVLH 125 VI T ++V E++ + D G + LFQ +L + +CH H V+H Sbjct: 77 YQVISTPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVH 134 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 RDLKP+N+L++ K+ADFGL+ G +R + Y APE++ G Y Sbjct: 135 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRD---SCGSPNYAAPEVISGRLYAGPE 191 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW 243 VDIWS G I ++ F D + LF+ R GV +P+Y Sbjct: 192 VDIWSCGVILYALLCGTLPFD-DEHVPTLFKKIRG----------GVFYIPEY------- 233 Query: 244 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 L+ +LL ML DP KR + K H +F+ Sbjct: 234 -----------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 266 >5J5T-A nrPDB Length = 370 Score = 107 bits (268), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 83/287 (28%), Positives = 136/287 (47%), Gaps = 31/287 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E+F+ +++IG GTYG VYKARN TGE+ A+K I+L+ + + +EI ++K+ HP Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDF--AVVQQEIIMMKDCKHP 61 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF-QLLQGLAFCHS 120 NIV +KL++ EF D +TG L +Y+ + LQGL + HS Sbjct: 62 NIVAYFGSYLRRDKLWICMEFCGGG--SLQDIYHVTGPLSELQIAYVSRETLQGLYYLHS 119 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY- 179 +HRD+K N+L+ G +KLADFG++ + + T ++ APE+ + Sbjct: 120 KGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKG 179 Query: 180 -YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y+ D+W++G E+ L P ++ + +F L T P + + Sbjct: 180 GYNQLCDLWAVGITAIELA---ELQPPMFDLHPMRALF--LMTKSNFQPPKLKDKMKWSN 234 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 SF + + +K +P KR +A+ L HPF Sbjct: 235 SFHHFVKMALTK-------------------NPKKRPTAEKLLQHPF 262 >4RLP-A nrPDB Length = 288 Score = 107 bits (268), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 88/308 (28%), Positives = 144/308 (46%), Gaps = 59/308 (19%) Query: 2 ENFQKVEKIGEGTYGVVYKAR---NKLTGEVVALKKIRLDTETEGVPSTA--IREISLLK 56 E F+ + +G+G YG V++ R TG++ A+K ++ TA E ++L+ Sbjct: 5 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 64 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFLH-----QDLKK---FMDASALTGIPLPLIKSYL 108 E+ HP IV L+ T KLYL+ E+L L++ FM+ +A YL Sbjct: 65 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACF---------YL 115 Query: 109 FQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLW 167 ++ L H +++RDLKP+N+++N +G +KL DFGL + + T TH T+ Sbjct: 116 AEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE-SIHDGTVTHTFCGTIE 174 Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227 Y APEIL+ ++ AVD WSLG + +M+T F G++ + +I + Sbjct: 175 YMAPEILMRSG-HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC--------- 224 Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA-----LA 282 K + P P L ++ R LL ++L + R+ A A Sbjct: 225 ---------KLNLP-----------PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQA 264 Query: 283 HPFFQDVT 290 HPFF+ + Sbjct: 265 HPFFRHIN 272 >5KKR-C nrPDB Length = 395 Score = 107 bits (267), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 67/206 (32%), Positives = 110/206 (53%), Gaps = 10/206 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++F+K+ ++G G GVV+K +K +G V+A K I L+ + + + IRE+ +L E N P Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 126 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFC-H 119 IV +++ ++ + E H D G IP ++ +++GL + Sbjct: 127 YIVGFYGAFYSDGEISICME--HMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 184 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGCK 178 H+++HRD+KP N+L+N+ G IKL DFG++ G + + + V T Y +PE L G Sbjct: 185 KHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPERLQGT- 240 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFP 204 +YS DIWS+G EM R P Sbjct: 241 HYSVQSDIWSMGLSLVEMAVGRYPIP 266 >3EQC-A nrPDB Length = 360 Score = 107 bits (267), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 67/206 (32%), Positives = 110/206 (53%), Gaps = 10/206 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++F+K+ ++G G GVV+K +K +G V+A K I L+ + + + IRE+ +L E N P Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 91 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFC-H 119 IV +++ ++ + E H D G IP ++ +++GL + Sbjct: 92 YIVGFYGAFYSDGEISICME--HMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 149 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGCK 178 H+++HRD+KP N+L+N+ G IKL DFG++ G + + + V T Y +PE L G Sbjct: 150 KHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPERLQGT- 205 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFP 204 +YS DIWS+G EM R P Sbjct: 206 HYSVQSDIWSMGLSLVEMAVGRYPIP 231 >4AN9-A nrPDB Length = 301 Score = 107 bits (267), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 67/202 (33%), Positives = 109/202 (53%), Gaps = 10/202 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++F+K+ ++G G GVV+K +K +G V+A K I L+ + + + IRE+ +L E N P Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 67 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFC-H 119 IV +++ ++ + E H D G IP ++ +++GL + Sbjct: 68 YIVGFYGAFYSDGEISICME--HMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 125 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGCK 178 H+++HRD+KP N+L+N+ G IKL DFG++ G + +E V T Y +PE L G Sbjct: 126 KHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDEMANEFVGTRSYMSPERLQGT- 181 Query: 179 YYSTAVDIWSLGCIFAEMVTRR 200 +YS DIWS+G EM R Sbjct: 182 HYSVQSDIWSMGLSLVEMAVGR 203 >4L42-A nrPDB Length = 346 Score = 107 bits (267), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 88/308 (28%), Positives = 144/308 (46%), Gaps = 59/308 (19%) Query: 2 ENFQKVEKIGEGTYGVVYKAR---NKLTGEVVALKKIRLDTETEGVPSTA--IREISLLK 56 E F+ + +G+G YG V++ R TG++ A+K ++ TA E ++L+ Sbjct: 18 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 77 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFLH-----QDLKK---FMDASALTGIPLPLIKSYL 108 E+ HP IV L+ T KLYL+ E+L L++ FM+ +A YL Sbjct: 78 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACF---------YL 128 Query: 109 FQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLW 167 ++ L H +++RDLKP+N+++N +G +KL DFGL + + T TH T+ Sbjct: 129 AEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE-SIHDGTVTHTFCGTIE 187 Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227 Y APEIL+ ++ AVD WSLG + +M+T F G++ + +I + Sbjct: 188 YMAPEILMRSG-HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC--------- 237 Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA-----LA 282 K + P P L ++ R LL ++L + R+ A A Sbjct: 238 ---------KLNLP-----------PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQA 277 Query: 283 HPFFQDVT 290 HPFF+ + Sbjct: 278 HPFFRHIN 285 >1U5R-A nrPDB Length = 348 Score = 106 bits (265), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 68/202 (33%), Positives = 105/202 (51%), Gaps = 12/202 (5%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP-STAIREISLLKELNHPN 62 F + +IG G++G VY AR+ EVVA+KK+ + I+E+ L++L HPN Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPL--IKSYLFQLLQGLAFCHS 120 ++ E+ +LV E+ L D + PL I + LQGLA+ HS Sbjct: 116 TIQYRGCYLREHTAWLVMEYC---LGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHS 172 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK-- 178 H ++HRD+K N+L++ G +KL DFG A + P ++ V T ++ APE++L Sbjct: 173 HNMIHRDVKAGNILLSEPGLVKLGDFGSA-SIMAPANSF---VGTPYWMAPEVILAMDEG 228 Query: 179 YYSTAVDIWSLGCIFAEMVTRR 200 Y VD+WSLG E+ R+ Sbjct: 229 QYDGKVDVWSLGITCIELAERK 250 >2GCD-A nrPDB Length = 309 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 67/202 (33%), Positives = 106/202 (52%), Gaps = 12/202 (5%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP-STAIREISLLKELNHPN 62 F + +IG G++G VY AR+ EVVA+KK+ + I+E+ L++L HPN Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIK--SYLFQLLQGLAFCHS 120 ++ E+ +LV E+ L D + PL ++ + LQGLA+ HS Sbjct: 77 TIQYRGCYLREHTAWLVMEYC---LGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHS 133 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK-- 178 H ++HRD+K N+L++ G +KL DFG A + P ++ V T ++ APE++L Sbjct: 134 HNMIHRDVKAGNILLSEPGLVKLGDFGSA-SIMAPANSF---VGTPYWMAPEVILAMDEG 189 Query: 179 YYSTAVDIWSLGCIFAEMVTRR 200 Y VD+WSLG E+ R+ Sbjct: 190 QYDGKVDVWSLGITCIELAERK 211 >3TAC-A nrPDB Length = 361 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 83/296 (28%), Positives = 145/296 (48%), Gaps = 40/296 (13%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD--TETEGVPSTAI-REISLLKELNH 60 ++ E IG+G + VV + N+ TG+ A+K + + T + G+ + + RE S+ L H Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQ-----DLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 P+IV+LL+ ++ LY+VFEF+ ++ K DA + + Y+ Q+L+ L Sbjct: 88 PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYS--EAVASHYMRQILEAL 145 Query: 116 AFCHSHRVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 +CH + ++HRD+KP +L+ ++ +KL FG+A G V T + APE Sbjct: 146 RYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPE 205 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 ++ + Y VD+W G I +++ F G E R+F E + G Sbjct: 206 VVKR-EPYGKPVDVWGCGVILFILLSGCLPFYGTKE-----RLF-------EGIIKG--- 249 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 YK + +W+ + E + L+ +ML DP +RI+ AL HP+ ++ Sbjct: 250 --KYKMNPRQWSH---------ISESAKDLVRRMLMLDPAERITVYEALNHPWLKE 294 >2Q0N-A nrPDB Length = 301 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 83/292 (28%), Positives = 134/292 (45%), Gaps = 34/292 (11%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 KIGEG+ G+V A + +G++VA+KK +D + E+ ++++ H N+V++ + Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKK--MDLRKQQRRELLFNEVVIMRDYQHENVVEMYN 93 Query: 69 VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 128 ++L++V EFL D T + I + +LQ L+ H+ V+HRD+ Sbjct: 94 SYLVGDELWVVMEFLEGG--ALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 151 Query: 129 KPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWS 188 K ++L+ +G +KL+DFG V V T ++ APE L+ Y VDIWS Sbjct: 152 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVDIWS 210 Query: 189 LGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDF 248 LG + EMV G P P + +M + + P + + Sbjct: 211 LGIMVIEMVD---------------------GEPPYFNEPPLKAMKMIRDNLPPRLK-NL 248 Query: 249 SKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP---VPHLR 297 KV P L + L ++L DP +R +A L HPF P VP +R Sbjct: 249 HKVSPSL----KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMR 296 >4XBR-A nrPDB Length = 366 Score = 106 bits (264), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 83/292 (28%), Positives = 134/292 (45%), Gaps = 34/292 (11%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 KIGEG+ G+V A + +G++VA+KK +D + E+ ++++ H N+V++ + Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKK--MDLRKQQRRELLFNEVVIMRDYQHENVVEMYN 158 Query: 69 VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 128 ++L++V EFL D T + I + +LQ L+ H+ V+HRD+ Sbjct: 159 SYLVGDELWVVMEFLEG--GALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 216 Query: 129 KPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWS 188 K ++L+ +G +KL+DFG V V T ++ APE L+ Y VDIWS Sbjct: 217 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVDIWS 275 Query: 189 LGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDF 248 LG + EMV G P P + +M + + P + + Sbjct: 276 LGIMVIEMVD---------------------GEPPYFNEPPLKAMKMIRDNLPPRLK-NL 313 Query: 249 SKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP---VPHLR 297 KV P L + L ++L DP +R +A L HPF P VP +R Sbjct: 314 HKVSPSL----KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMR 361 >4JDH-A nrPDB Length = 346 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 83/292 (28%), Positives = 134/292 (45%), Gaps = 34/292 (11%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 KIGEG+ G+V A + +G++VA+KK +D + E+ ++++ H N+V++ + Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKK--MDLRKQQRRELLFNEVVIMRDYQHENVVEMYN 138 Query: 69 VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 128 ++L++V EFL D T + I + +LQ L+ H+ V+HRD+ Sbjct: 139 SYLVGDELWVVMEFLEGG--ALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 196 Query: 129 KPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWS 188 K ++L+ +G +KL+DFG V V T ++ APE L+ Y VDIWS Sbjct: 197 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVDIWS 255 Query: 189 LGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDF 248 LG + EMV G P P + +M + + P + + Sbjct: 256 LGIMVIEMVD---------------------GEPPYFNEPPLKAMKMIRDNLPPRLK-NL 293 Query: 249 SKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP---VPHLR 297 KV P L + L ++L DP +R +A L HPF P VP +R Sbjct: 294 HKVSPSL----KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMR 341 >3KK8-A nrPDB Length = 284 Score = 105 bits (262), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 89/288 (30%), Positives = 138/288 (47%), Gaps = 31/288 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +N+ E++G+G + VV + +K TG A K I + RE + ++L HP Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 65 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L D I E+ YLVF+ + + F D A + Q+L+ +A+CHS+ Sbjct: 66 NIVRLHDSIQEESFHYLVFDLVTGG-ELFEDIVAREFYSEADASHCIQQILESIAYCHSN 124 Query: 122 RVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 ++HR+LKP+NLL+ ++ A+KLADFGLA + T Y +PE+L Sbjct: 125 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSPEVLKK-D 182 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 YS VDIW+ G I ++ +P + DQ R++ + G P Sbjct: 183 PYSKPVDIWACGVILYILLVG---YPPFWDEDQ-HRLYAQIKA-------GAYDYPS--- 228 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P+W V P + +SL+ ML +P KRI+A AL P+ Sbjct: 229 --PEW-----DTVTP----EAKSLIDSMLTVNPKKRITADQALKVPWI 265 >4FIE-A nrPDB Length = 423 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 83/292 (28%), Positives = 134/292 (45%), Gaps = 34/292 (11%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 KIGEG+ G+V A + +G++VA+KK +D + E+ ++++ H N+V++ + Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKK--MDLRKQQRRELLFNEVVIMRDYQHENVVEMYN 215 Query: 69 VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 128 ++L++V EFL D T + I + +LQ L+ H+ V+HRD+ Sbjct: 216 SYLVGDELWVVMEFLEGG--ALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 273 Query: 129 KPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWS 188 K ++L+ +G +KL+DFG V V T ++ APE L+ Y VDIWS Sbjct: 274 KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVDIWS 332 Query: 189 LGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDF 248 LG + EMV G P P + +M + + P + + Sbjct: 333 LGIMVIEMVD---------------------GEPPYFNEPPLKAMKMIRDNLPPRLK-NL 370 Query: 249 SKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP---VPHLR 297 KV P L + L ++L DP +R +A L HPF P VP +R Sbjct: 371 HKVSPSL----KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMR 418 >5YV8-A nrPDB Length = 298 Score = 104 bits (260), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 80/306 (26%), Positives = 137/306 (44%), Gaps = 57/306 (18%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDT------------------------ETEG 43 ++IG+G+YGVV A N+ A+K + + G Sbjct: 19 DEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRG 78 Query: 44 VPSTAIREISLLKELNHPNIVKLLDVIH--TENKLYLVFEFLHQDLKKFMDASALTGIPL 101 +EI++LK+L+HPN+VKL++V+ E+ LY+VFE ++Q M+ L + Sbjct: 79 PIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQ--GPVMEVPTLKPLSE 136 Query: 102 PLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTH 161 + Y L++G+ + H +++HRD+KP NLL+ +G IK+ADFG++ F ++ Sbjct: 137 DQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSN 196 Query: 162 EVVTLWYRAPEILLGCK--YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTL 219 V T + APE L + + A+D+W++G V + F Sbjct: 197 TVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF---------------- 240 Query: 220 GTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKA 279 DE + + + FP P + ED + L+++ML +P RI Sbjct: 241 --MDERIMCLHSKIKSQALEFPDQ---------PDIAEDLKDLITRMLDKNPESRIVVPE 289 Query: 280 ALAHPF 285 HP+ Sbjct: 290 IKLHPW 295 >3RAW-A nrPDB Length = 381 Score = 104 bits (260), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 95/338 (28%), Positives = 148/338 (43%), Gaps = 64/338 (18%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEV-VALKKIRLDTETEGVPSTAIREISLLKELNH 60 E ++ V +GEGT+G V + + G+ VALK IR + I + +KE + Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDK 110 Query: 61 PN---IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 N V + D + + + FE L ++ +F+ + PLP ++ +QL L F Sbjct: 111 ENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRF 170 Query: 118 CHSHRVLHRDLKPQNLL-INTE------------------GAIKLADFGLARAFGVPVRT 158 H +++ H DLKP+N+L +N+E +I++ADFG A T Sbjct: 171 LHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA--------T 222 Query: 159 YTHE-----VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLF 213 + HE V T YR PE++L ++ D+WS+GCI E LF + L Sbjct: 223 FDHEHHTTIVATRHYRPPEVILELG-WAQPCDVWSIGCILFEYYRGFTLFQTHENREHLV 281 Query: 214 RIFRTLG-TPDEV---------------VWPGVTSMPDY-----KPSFPKWARQDFSKVV 252 + + LG P + VW +S Y KP + QD + V Sbjct: 282 MMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKP-LKSYMLQDSLEHV 340 Query: 253 PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 D L+ +ML +DP +RI+ AL HPFF +T Sbjct: 341 QLFD-----LMRRMLEFDPAQRITLAEALLHPFFAGLT 373 >2BDW-A nrPDB Length = 362 Score = 104 bits (259), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 89/288 (30%), Positives = 138/288 (47%), Gaps = 31/288 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +N+ E++G+G + VV + +K TG A K I + RE + ++L HP Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 88 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L D I E+ YLVF+ + + F D A + Q+L+ +A+CHS+ Sbjct: 89 NIVRLHDSIQEESFHYLVFDLVTGG-ELFEDIVAREFYSEADASHCIQQILESIAYCHSN 147 Query: 122 RVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 ++HR+LKP+NLL+ ++ A+KLADFGLA + T Y +PE+L Sbjct: 148 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSPEVLKK-D 205 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 YS VDIW+ G I ++ +P + DQ R++ + G P Sbjct: 206 PYSKPVDIWACGVILYILLVG---YPPFWDEDQ-HRLYAQIKA-------GAYDYPS--- 251 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P+W V P + +SL+ ML +P KRI+A AL P+ Sbjct: 252 --PEW-----DTVTP----EAKSLIDSMLTVNPKKRITADQALKVPWI 288 >1S9I-A nrPDB Length = 354 Score = 103 bits (258), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 70/223 (31%), Positives = 121/223 (54%), Gaps = 24/223 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++F+++ ++G G GVV K +++ +G ++A K I L+ + + + IRE+ +L E N P Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 74 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG-------IPLPLIKSYLFQLLQG 114 IV +++ ++ + E MD +L IP ++ +L+G Sbjct: 75 YIVGFYGAFYSDGEISICMEH--------MDGGSLDQVLKEAKRIPEEILGKVSIAVLRG 126 Query: 115 LAFC-HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPE 172 LA+ H+++HRD+KP N+L+N+ G IKL DFG++ G + + + V T Y APE Sbjct: 127 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMAPE 183 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEM-VTRRALFPGDS-EIDQLF 213 L G +YS DIWS+G E+ V R + P D+ E++ +F Sbjct: 184 RLQGT-HYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIF 225 >5X8I-B nrPDB Length = 346 Score = 103 bits (258), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 98/337 (29%), Positives = 147/337 (43%), Gaps = 60/337 (17%) Query: 4 FQKVEKIGEGTYG-VVYKARNKLTGEVVALKKIR-LDTETEGVPSTAIREISLLKELN-- 59 ++ V+ +GEG +G VV +K G VA+K ++ +D E S EI +L+ LN Sbjct: 15 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARS----EIQVLEHLNTT 70 Query: 60 HPN----IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 PN V++L+ + +VFE L F+ + L I+ +Q+ + + Sbjct: 71 DPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSV 130 Query: 116 AFCHSHRVLHRDLKPQNLLI----NTEG---------------AIKLADFGLARAFGVPV 156 F HS+++ H DLKP+N+L TE IK+ DFG A Sbjct: 131 NFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA------- 183 Query: 157 RTYTHE-----VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQ 211 TY E V T YRAPE++L +S D+WS+GCI E +FP + Sbjct: 184 -TYDDEHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEYYLGFTVFPTHDSKEH 241 Query: 212 LFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW-----ARQDFSKVVPPLDEDGRS----- 261 L + R LG + + + W A + S+ PL E S Sbjct: 242 LAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEH 301 Query: 262 -----LLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293 L+ +ML YDP KRI+ + AL HPFF + K + Sbjct: 302 ERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 338 >2VZ6-A nrPDB Length = 313 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 85/286 (29%), Positives = 134/286 (46%), Gaps = 30/286 (10%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 +Q E++G+G + VV + L G+ A K I + RE + + L HPNI Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 V+L D I E YL+F+ + + F D A + Q+L+ + CH V Sbjct: 84 VRLHDSISEEGHHYLIFDLVTGG-ELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 142 Query: 124 LHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 +HRDLKP+NLL+ ++ A+KLADFGLA + + T Y +PE+L Y Sbjct: 143 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-DPY 201 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VD+W+ G I ++ +P + DQ R+++ + G P Sbjct: 202 GKPVDLWACGVILYILLVG---YPPFWDEDQ-HRLYQQIKA-------GAYDFPS----- 245 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P+W V P + + L+++ML +P+KRI+A AL HP+ Sbjct: 246 PEW-----DTVTP----EAKDLINKMLTINPSKRITAAEALKHPWI 282 >3BHH-A nrPDB Length = 295 Score = 103 bits (256), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 87/287 (30%), Positives = 131/287 (45%), Gaps = 30/287 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + +Q E IG+G + VV + TG A K I + RE + + L H Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L D I E YLVF+ + + F D A + Q+L+ + CH Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGG-ELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 122 Query: 122 RVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 V+HRDLKP+NLL+ ++ A+KLADFGLA + + T Y +PE+L + Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK-E 181 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y VDIW+ G I ++ F D + +L++ + G P Sbjct: 182 AYGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQIKA----------GAYDFPS--- 227 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 P+W V P + ++L++QML +P KRI+A AL HP+ Sbjct: 228 --PEW-----DTVTP----EAKNLINQMLTINPAKRITAHEALKHPW 263 >5UNP-A nrPDB Length = 369 Score = 102 bits (255), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 91/340 (26%), Positives = 148/340 (43%), Gaps = 58/340 (17%) Query: 2 ENFQKVEKIGEGTYG-VVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 E ++ V +GEGT+G VV ++ G VALK I+ E A EI++L+++N Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK---NVEKYKEAARLEINVLEKINE 90 Query: 61 PN------IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 + V++ D + + FE L F+ + P+ ++ FQL Q Sbjct: 91 KDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQA 150 Query: 115 LAFCHSHRVLHRDLKPQNLL-INTE------------------GAIKLADFGLARAFGVP 155 + F H +++ H DLKP+N+L +N++ A+++ DFG A Sbjct: 151 VKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA------ 204 Query: 156 VRTYTHE-----VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEID 210 T+ HE V T YRAPE++L +S D+WS+GCI E LF + Sbjct: 205 --TFDHEHHSTIVSTRHYRAPEVILELG-WSQPCDVWSIGCIIFEYYVGFTLFQTHDNRE 261 Query: 211 QLFRIFRTLG-TPDEVVWPGVTSMPDYK--------PSFPKWARQDFSKVVPPLDEDGR- 260 L + R LG P ++ Y+ S ++ R++ + L + Sbjct: 262 HLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEE 321 Query: 261 -----SLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPH 295 L+ ML Y+P KR++ AL HPFF + P+ Sbjct: 322 HHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 361 >2V7O-A nrPDB Length = 336 Score = 102 bits (255), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 85/287 (29%), Positives = 133/287 (46%), Gaps = 30/287 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +++Q E++G+G + VV + K + A K I + RE + + L HP Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 90 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L D I E YLVF+ + + F D A + Q+L+ + H H Sbjct: 91 NIVRLHDSISEEGFHYLVFDLVTGG-ELFEDIVAREYYSEADASHCIHQILESVNHIHQH 149 Query: 122 RVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 ++HRDLKP+NLL+ ++ A+KLADFGLA + + T Y +PE+L Sbjct: 150 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRK-D 208 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y VDIW+ G I ++ F D + +L++ + G P Sbjct: 209 PYGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQIKA----------GAYDFPS--- 254 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 P+W V P + ++L++QML +P KRI+A AL HP+ Sbjct: 255 --PEW-----DTVTP----EAKNLINQMLTINPAKRITADQALKHPW 290 >5U6Y-A nrPDB Length = 461 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 85/286 (29%), Positives = 134/286 (46%), Gaps = 30/286 (10%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 +Q E++G+G + VV + L G+ A K I + RE + + L HPNI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 V+L D I E YL+F+ + + F D A + Q+L+ + CH V Sbjct: 62 VRLHDSISEEGHHYLIFDLV-TGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 120 Query: 124 LHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 +HRDLKP+NLL+ ++ A+KLADFGLA + + T Y +PE+L Y Sbjct: 121 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-DPY 179 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VD+W+ G I ++ +P + DQ R+++ + G P Sbjct: 180 GKPVDLWACGVILYILLVG---YPPFWDEDQ-HRLYQQIKA-------GAYDFPS----- 223 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P+W V P + + L+++ML +P+KRI+A AL HP+ Sbjct: 224 PEW-----DTVTP----EAKDLINKMLTINPSKRITAAEALKHPWI 260 >2Y7J-A nrPDB Length = 365 Score = 102 bits (254), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 81/291 (27%), Positives = 135/291 (46%), Gaps = 41/291 (14%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTET------EGVPSTAIREISLLKEL-NHPN 62 IG G VV + ++ TG A+K + + E E V RE +L+++ HP+ Sbjct: 102 IGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPH 161 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 I+ L+D + + ++LVF+ + + + F + + +S + LL+ ++F H++ Sbjct: 162 IITLIDSYESSSFMFLVFDLMRKG-ELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANN 220 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY--- 179 ++HRDLKP+N+L++ I+L+DFG + P T Y APEI L C Sbjct: 221 IVHRDLKPENILLDDNMQIRLSDFGFSCHLE-PGEKLRELCGTPGYLAPEI-LKCSMDET 278 Query: 180 ---YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 Y VD+W+ G I ++ F +I L I Y Sbjct: 279 HPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEG----------------QY 322 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 + S P+W D S V + L+S++L DP R++A+ AL HPFF+ Sbjct: 323 QFSSPEW--DDRSSTV-------KDLISRLLQVDPEARLTAEQALQHPFFE 364 >4EQM-A nrPDB Length = 294 Score = 102 bits (254), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 64/211 (30%), Positives = 114/211 (54%), Gaps = 6/211 (2%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD-TETEGVPSTAIREISLLKELNH 60 E ++ V+K+G G VY A + + VA+K I + E E RE+ +L+H Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSH 70 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 NIV ++DV ++ YLV E++ L +++++ + + ++ Q+L G+ H Sbjct: 71 QNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAI--NFTNQILDGIKHAH 128 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGCK 178 R++HRD+KPQN+LI++ +K+ DFG+A+A T T+ V+ T+ Y +PE G + Sbjct: 129 DMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKG-E 187 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209 DI+S+G + EM+ F G++ + Sbjct: 188 ATDECTDIYSIGIVLYEMLVGEPPFNGETAV 218 >4WNO-A nrPDB Length = 287 Score = 102 bits (254), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 71/224 (31%), Positives = 115/224 (51%), Gaps = 18/224 (8%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEV-VALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 F + + IG G + VV+K R++ ++ VA+K I + + +EI +LKEL H N Sbjct: 20 FSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKS-QTLLGKEIKILKELKHEN 78 Query: 63 IVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 IV L D N +YLV E+ + DL ++ A+ + I+ +L Q+ + HS Sbjct: 79 IVALYDFQEMANSVYLVMEYCNGGDLADYL--HAMRTLSEDTIRLFLQQIAGAMRLLHSK 136 Query: 122 RVLHRDLKPQNLLINTEGA---------IKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 ++HRDLKPQN+L++ +K+ADFG AR + T + Y APE Sbjct: 137 GIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT-LCGSPMYMAPE 195 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF 216 +++ ++Y D+WS+G I + +T +A F S D R+F Sbjct: 196 VIM-SQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD--LRLF 236 >3IS5-A nrPDB Length = 285 Score = 101 bits (252), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 84/286 (29%), Positives = 126/286 (44%), Gaps = 38/286 (13%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELNHPNIVKLL 67 K+G G +G V+ + +G +K I D VP I EI +LK L+HPNI+K+ Sbjct: 29 KLGSGAFGDVHLVEERSSGLERVIKTINKDRSQ--VPMEQIEAEIEVLKSLDHPNIIKIF 86 Query: 68 DVIHTENKLYLVFEFLH--QDLKKFMDASAL-TGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 +V + +Y+V E + L++ + A A + + + Q++ LA+ HS V+ Sbjct: 87 EVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHSQHVV 146 Query: 125 HRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 H+DLKP+N+L IK+ DFGLA F + T+ T Y APE+ + + Sbjct: 147 HKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHS-TNAAGTALYMAPEVFK--RDVT 203 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 DIWS G + ++T F G S +EV P+Y Sbjct: 204 FKCDIWSAGVVMYFLLTGCLPFTGTS--------------LEEVQQKATYKEPNYAVE-- 247 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 PL LL QML DP +R SA L H +F+ Sbjct: 248 ----------CRPLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFK 283 >2VN9-A nrPDB Length = 301 Score = 101 bits (251), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 85/288 (29%), Positives = 135/288 (46%), Gaps = 30/288 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + +Q E++G+G + VV + TG+ A K I + RE + + L HP Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 63 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L D I E YLVF+ + + F D A + Q+L+ + CH + Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGG-ELFEDIVAREYYSEADASHCIQQILESVNHCHLN 122 Query: 122 RVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 ++HRDLKP+NLL+ ++ A+KLADFGLA + + T Y +PE+L Sbjct: 123 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK-D 181 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y VD+W+ G I ++ +P + DQ R+++ + G P Sbjct: 182 PYGKPVDMWACGVILYILLVG---YPPFWDEDQ-HRLYQQIKA-------GAYDFPS--- 227 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P+W V P + + L+++ML +P KRI+A AL HP+ Sbjct: 228 --PEW-----DTVTP----EAKDLINKMLTINPAKRITASEALKHPWI 264 >5WAX-A nrPDB Length = 310 Score = 101 bits (251), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 84/291 (28%), Positives = 134/291 (46%), Gaps = 38/291 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ V IG G +GV RN+ G++VA+K I E + REI + L HP Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIE---RGEKIDENVQREIINHRSLRHP 67 Query: 62 NIVKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 NI++ +VI T L +V E+ + ++ +A + + + QL+ G+++CH Sbjct: 68 NIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSE---DEARFFFQQLISGVSYCH 124 Query: 120 SHRVLHRDLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 S +V HRDLK +N L++ A +K+ DFG +++ V V T Y APE+LL Sbjct: 125 SMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPEVLLKK 183 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR--IFRTLGTPDEVVWPGVTSMPD 235 +Y D+WS G M+ F D + + FR I R LG S+PD Sbjct: 184 EYDGKVADVWSCGVTLYVMLVGAYPFE-DPDEPKNFRKTIQRILGVQ--------YSIPD 234 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 Y P+ + L+S++ +P RI+ HP+F Sbjct: 235 YVHISPEC----------------QDLISRIFVANPATRITIPEIRNHPWF 269 >4AF3-A nrPDB Length = 292 Score = 100 bits (250), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 84/301 (27%), Positives = 146/301 (48%), Gaps = 48/301 (15%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59 +++F+ +G+G +G VY AR K + +VALK + + E EGV REI + L+ Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH 81 Query: 60 HPNIVKLLDVIHTENKLYLVFEF-----LHQDLKK--FMDASALTGIPLPLIKSYLFQLL 112 HPNI++L + + ++YL+ E+ L+++L+K D I + +L Sbjct: 82 HPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI--------MEELA 133 Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 L +CH +V+HRD+KP+NLL+ +G +K+ADFG + P TL Y PE Sbjct: 134 DALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGW--SVHAPSLRRKTMCGTLDYLPPE 191 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 ++ G + ++ VD+W +G + E++ F S + RI + Sbjct: 192 MIEG-RMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV-------------- 236 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 D K F VP +D L+S++L ++P++R+ AHP+ + ++ Sbjct: 237 --DLK----------FPASVPTGAQD---LISKLLRHNPSERLPLAQVSAHPWVRANSRR 281 Query: 293 V 293 V Sbjct: 282 V 282 >3SOA-A nrPDB Length = 444 Score = 100 bits (250), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 84/288 (29%), Positives = 134/288 (46%), Gaps = 30/288 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E +Q E++G+G + VV + L G+ A I + RE + + L HP Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L D I E YL+F+ + + F D A + Q+L+ + CH Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGG-ELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 129 Query: 122 RVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 V+HR+LKP+NLL+ ++ A+KLADFGLA + + T Y +PE+L Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-D 188 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y VD+W+ G I ++ +P + DQ R+++ + G P Sbjct: 189 PYGKPVDLWACGVILYILLVG---YPPFWDEDQ-HRLYQQIKA-------GAYDFPS--- 234 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P+W V P + + L+++ML +P+KRI+A AL HP+ Sbjct: 235 --PEW-----DTVTP----EAKDLINKMLTINPSKRITAAEALKHPWI 271 >1KOA-A nrPDB Length = 491 Score = 100 bits (249), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 74/296 (25%), Positives = 134/296 (45%), Gaps = 35/296 (11%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++++ E++G G +GVV++ + TG A K + T E T +EI + L H Sbjct: 50 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVM--TPHESDKETVRKEIQTMSVLRH 107 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 P +V L D +N++ +++EF+ A + Y+ Q+ +GL H Sbjct: 108 PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE 167 Query: 121 HRVLHRDLKPQNLLINTE--GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG-- 176 + +H DLKP+N++ T+ +KL DFGL A P ++ T + APE+ G Sbjct: 168 NNYVHLDLKPENIMFTTKRSNELKLIDFGLT-AHLDPKQSVKVTTGTAEFAAPEVAEGKP 226 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 YY+ D+WS+G + +++ + F G+++ + L + D+ + G++ Sbjct: 227 VGYYT---DMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGIS----- 278 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 EDG+ + ++L DPN R++ AL HP+ P Sbjct: 279 --------------------EDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAP 314 >3UTO-A nrPDB Length = 573 Score = 100 bits (249), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 73/296 (24%), Positives = 135/296 (45%), Gaps = 35/296 (11%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++++ E++G G +GVV++ + TG A K + E++ T +EI + L H Sbjct: 156 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESD--KETVRKEIQTMSVLRH 213 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 P +V L D +N++ +++EF+ A + Y+ Q+ +GL H Sbjct: 214 PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE 273 Query: 121 HRVLHRDLKPQNLLINTE--GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG-- 176 + +H DLKP+N++ T+ +KL DFGL A P ++ T + APE+ G Sbjct: 274 NNYVHLDLKPENIMFTTKRSNELKLIDFGLT-AHLDPKQSVKVTTGTAEFAAPEVAEGKP 332 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 YY+ D+WS+G + +++ + F G+++ + L + D+ + G++ Sbjct: 333 VGYYT---DMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGIS----- 384 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 EDG+ + ++L DPN R++ AL HP+ P Sbjct: 385 --------------------EDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAP 420 >4YZB-A nrPDB Length = 491 Score = 100 bits (249), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 86/290 (29%), Positives = 143/290 (49%), Gaps = 49/290 (16%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 +G+G++G V ++K+TG+ A+K I + + + ++E+ LLK+L+HPNI+KL + Sbjct: 38 LGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYE 97 Query: 69 VIHTENKLYLVFEF-----LHQDL---KKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 + YLV E L ++ K+F + A I Q+L G+ + H Sbjct: 98 FFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIR---------QVLSGITYMHK 148 Query: 121 HRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 ++++HRDLKP+NLL+ + I++ DFGL+ F + ++ T +Y APE+L G Sbjct: 149 NKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHF-ESTKKMKDKIGTAYYIAPEVLHGT 207 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 Y D+WS G I +++ F G +E D L ++ + T D Sbjct: 208 --YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFD-------------- 251 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 P+W KV P + L+ +ML Y P RISA+ AL H + + Sbjct: 252 --LPQW-----KKVSEP----AKDLIRKMLAYVPTMRISARDALEHEWLK 290 >2Z7Q-A nrPDB Length = 321 Score = 100 bits (248), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 75/226 (33%), Positives = 119/226 (52%), Gaps = 10/226 (4%) Query: 3 NFQKVEKIGEGTYGVVYKARNKL---TGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 +F+ ++ +G+G++G V+ R +G + A+K ++ T E +L ++N Sbjct: 29 HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVN 88 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HP +VKL TE KLYL+ +FL DL F S +K YL +L GL Sbjct: 89 HPFVVKLHYAFQTEGKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALGLDHL 146 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLAR-AFGVPVRTYTHEVVTLWYRAPEILLGC 177 HS +++RDLKP+N+L++ EG IKL DFGL++ A + Y+ T+ Y APE+ + Sbjct: 147 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSF-CGTVEYMAPEV-VNR 204 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRT-LGTP 222 + +S + D WS G + EM+T F G + + I + LG P Sbjct: 205 QGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP 250 >6E2O-A nrPDB Length = 295 Score = 100 bits (248), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 88/296 (29%), Positives = 130/296 (43%), Gaps = 52/296 (17%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELNHPNIVKLLD 68 +G+GTYG+VY R+ +A+K+I E + S + EI+L K L H NIV+ L Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSRYSQPLHEEIALHKHLKHKNIVQYLG 86 Query: 69 VIHTENKLYLVF----------EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 +EN +F L D G Y Q+L+GL + Sbjct: 87 SF-SENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGF-------YTKQILEGLKYL 138 Query: 119 HSHRVLHRDLKPQNLLINT-EGAIKLADFGLA-RAFGVPVRTYTHEVVTLWYRAPEIL-L 175 H ++++HRD+K N+LINT G +K++DFG + R G+ T T TL Y APEI+ Sbjct: 139 HDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETF-TGTLQYMAPEIIDK 197 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 G + Y A DIWSLGC EM T + F LG P ++ M Sbjct: 198 GPRGYGKAADIWSLGCTIIEMATGKP-------------PFYELGEPQAAMFK--VGMFK 242 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 P P+ + + ++ + + DP+KR A L F + +K Sbjct: 243 VHPEIPE-----------SMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSK 287 >2X4F-A nrPDB Length = 373 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 81/289 (28%), Positives = 135/289 (46%), Gaps = 39/289 (13%) Query: 6 KVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPST--AIREISLLKELNHPNI 63 K E +G G +G V+K TG +A K I+ T G+ EIS++ +L+H N+ Sbjct: 93 KTEILGGGRFGQVHKCEETATGLKLAAKIIK----TRGMKDKEEVKNEISVMNQLDHANL 148 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF--QLLQGLAFCHSH 121 ++L D ++N + LV E++ D + D L + + LF Q+ +G+ H Sbjct: 149 IQLYDAFESKNDIVLVMEYV--DGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQM 206 Query: 122 RVLHRDLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 +LH DLKP+N+L A IK+ DFGLAR + P T + APE+ + + Sbjct: 207 YILHLDLKPENILCVNRDAKQIKIIDFGLARRYK-PREKLKVNFGTPEFLAPEV-VNYDF 264 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 S D+WS+G I +++ + F GD++ + L I Sbjct: 265 VSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILAC--------------------- 303 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 +W +D + + E+ + +S++L + + RISA AL HP+ D Sbjct: 304 --RWDLED--EEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSD 348 >5HVK-A nrPDB Length = 315 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 109/207 (52%), Gaps = 19/207 (9%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKK-IRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 E +G+G +G K ++ TGEV+ +K+ IR D ET+ T ++E+ +++ L HPN++K Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQ---RTFLKEVKVMRCLEHPNVLKF 76 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 + V++ + +L + E++ + + S + P S+ + G+A+ HS ++HR Sbjct: 77 IGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHR 136 Query: 127 DLKPQNLLINTEGAIKLADFGLA-------------RAFGVPVRTYTHEVV-TLWYRAPE 172 +L N L+ + +ADFGLA R+ P R + VV ++ APE Sbjct: 137 NLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPE 196 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTR 199 ++ G + Y VD++S G + E++ R Sbjct: 197 MING-RSYDEKVDVFSFGIVLCEIIGR 222 >2XIK-A nrPDB Length = 294 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 69/201 (34%), Positives = 110/201 (54%), Gaps = 14/201 (6%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E F K+++IG+G++G VYK + T EVVA+K I L+ + + +EI++L + + P Sbjct: 19 ELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ-QEITVLSQCDSP 77 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGI-PLPLIKSY----LFQLLQGLA 116 I + KL+++ E+L SAL + P PL ++Y L ++L+GL Sbjct: 78 YITRYFGSYLKSTKLWIIMEYLG-------GGSALDLLKPGPLEETYIATILREILKGLD 130 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 + HS R +HRD+K N+L++ +G +KLADFG+A V T ++ APE++ Sbjct: 131 YLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ 190 Query: 177 CKYYSTAVDIWSLGCIFAEMV 197 Y A DIWSLG E+ Sbjct: 191 SAYDFKA-DIWSLGITAIELA 210 >1ZXE-A nrPDB Length = 303 Score = 99.0 bits (245), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 67/223 (30%), Positives = 111/223 (49%), Gaps = 32/223 (14%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP- 61 +F+++ +G+G +G V KARN L A+KKIR TE ST + E+ LL LNH Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIR---HTEEKLSTILSEVMLLASLNHQY 63 Query: 62 ------------NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYL 108 N VK + + ++ L++ E+ ++ L + + L + + Sbjct: 64 VVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFR 123 Query: 109 FQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLA----RAFGV---------- 154 Q+L+ L++ HS ++HR+LKP N+ I+ +K+ DFGLA R+ + Sbjct: 124 -QILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPG 182 Query: 155 PVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMV 197 T + T Y A E+L G +Y+ +D++SLG IF EM+ Sbjct: 183 SSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI 225 >5JZN-A nrPDB Length = 280 Score = 99.0 bits (245), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 87/292 (29%), Positives = 130/292 (44%), Gaps = 35/292 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E ++ IG+G + VV + + T ALK I+ ++ G E+S+L+ + HP Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIK-KSKCRGKEHMIQNEVSILRRVKHP 77 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKS-YLFQLLQGLAFCHS 120 NIV L++ + +LYLV E + DA T S L+ L + + HS Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKG--GDLFDAITSTNKYTERDASGMLYNLASAIKYLHS 135 Query: 121 HRVLHRDLKPQNLLI----NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 ++HRD+KP+NLL+ + ++KL DFGLA P+ T T Y APEI+ Sbjct: 136 LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCG---TPTYVAPEIIAE 192 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 Y VDIW+ G I L G F FR G EV++ + Sbjct: 193 TG-YGLKVDIWAAGVI------TYILLCG-------FPPFRGSGDDQEVLFDQILMGQVD 238 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 PS P W + + + L++ ML D ++R SA L HP+ D Sbjct: 239 FPS-PYWDN---------VSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 280 >4QMW-A nrPDB Length = 310 Score = 99.0 bits (245), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 69/201 (34%), Positives = 110/201 (54%), Gaps = 14/201 (6%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E F K+EKIG+G++G V+K + T +VVA+K I L+ + + +EI++L + + P Sbjct: 29 ELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ-QEITVLSQCDSP 87 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGI-PLPL----IKSYLFQLLQGLA 116 + K + KL+++ E+L SAL + P PL I + L ++L+GL Sbjct: 88 YVTKYYGSYLKDTKLWIIMEYLG-------GGSALDLLEPGPLDETQIATILREILKGLD 140 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 + HS + +HRD+K N+L++ G +KLADFG+A V T ++ APE++ Sbjct: 141 YLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ 200 Query: 177 CKYYSTAVDIWSLGCIFAEMV 197 Y S A DIWSLG E+ Sbjct: 201 SAYDSKA-DIWSLGITAIELA 220 >5IG1-A nrPDB Length = 344 Score = 98.6 bits (244), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 68/197 (34%), Positives = 97/197 (49%), Gaps = 26/197 (13%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 IG+G + V++ NK TGEV A+K I L + + REI + L H +IV + Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRRA 84 Query: 70 IHTENKLYLVFEFLHQD-------LKKFM---DASALTGIPLPLIKSYLFQLLQGLAFCH 119 E+ YLVFE++ +KF DASA + Q+L L CH Sbjct: 85 FRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASAC-----------MHQILSALQHCH 133 Query: 120 SHRVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 S ++HRDLKP+NLL+ ++ +K+ DFGLA TY T Y +PE++ Sbjct: 134 SKNIIHRDLKPENLLLASKDPNAPVKITDFGLA-VIMEQGPTYFGFAGTPGYLSPEVIRR 192 Query: 177 CKYYSTAVDIWSLGCIF 193 Y TAVD+W+ G I Sbjct: 193 VP-YDTAVDVWACGVIL 208 >3UDB-A nrPDB Length = 317 Score = 98.6 bits (244), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 86/291 (29%), Positives = 134/291 (46%), Gaps = 38/291 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ V+ IG G +GV R+K E+VA+K I E + REI + L HP Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYIE---RGEKIDENVKREIINHRSLRHP 75 Query: 62 NIVKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 NIV+ +VI T L +V E+ + ++ +A + + + QL+ G+++ H Sbjct: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSE---DEARFFFQQLISGVSYAH 132 Query: 120 SHRVLHRDLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 + +V HRDLK +N L++ A +K+ADFG ++A V V T Y APE+LL Sbjct: 133 AMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKA-SVLHSQPKSAVGTPAYIAPEVLLKK 191 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR--IFRTLGTPDEVVWPGVTSMPD 235 +Y D+WS G M+ F D E + FR I R L Sbjct: 192 EYDGKVADVWSCGVTLYVMLVGAYPFE-DPEEPKNFRKTIHRILNV-------------- 236 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 ++A D+ + P + R L+S++ DP KRIS H +F Sbjct: 237 ------QYAIPDYVHISP----ECRHLISRIFVADPAKRISIPEIRNHEWF 277 >4FG9-A nrPDB Length = 320 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 77/280 (27%), Positives = 129/280 (46%), Gaps = 34/280 (12%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 +G G + V A +K T ++VA+K I + EG + EI++L ++ HPNIV L D+ Sbjct: 26 LGTGAFSEVILAEDKRTQKLVAIKCIAKEA-LEGKEGSMENEIAVLHKIKHPNIVALDDI 84 Query: 70 IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYL-FQLLQGLAFCHSHRVLHRDL 128 + LYL+ + + + D G S L FQ+L + + H ++HRDL Sbjct: 85 YESGGHLYLIMQLVSG--GELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDL 142 Query: 129 KPQNLL---INTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVD 185 KP+NLL ++ + I ++DFGL++ P + T Y APE+ L K YS AVD Sbjct: 143 KPENLLYYSLDEDSKIMISDFGLSK-MEDPGSVLSTACGTPGYVAPEV-LAQKPYSKAVD 200 Query: 186 IWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR 245 WS+G I ++ F +++ +I + +Y+ P W Sbjct: 201 CWSIGVIAYILLCGYPPFYDENDAKLFEQILKA----------------EYEFDSPYW-- 242 Query: 246 QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 + + + + ++ DP KR + + AL HP+ Sbjct: 243 -------DDISDSAKDFIRHLMEKDPEKRFTCEQALQHPW 275 >3ZUT-A nrPDB Length = 362 Score = 97.8 bits (242), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 84/291 (28%), Positives = 134/291 (46%), Gaps = 38/291 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ V+ IG G +GV R+K + E+VA+K I E + REI + L HP Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE---RGEKIDENVKREIINHRSLRHP 75 Query: 62 NIVKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 NIV+ +VI T L +V E+ + ++ +A + + + QL+ G+++CH Sbjct: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSE---DEARFFFQQLISGVSYCH 132 Query: 120 SHRVLHRDLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 + +V HRDLK +N L++ A +K+ FG +++ V V T Y APE+LL Sbjct: 133 AMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKS-SVLHSQPKSTVGTPAYIAPEVLLKK 191 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR--IFRTLGTPDEVVWPGVTSMPD 235 +Y D+WS G M+ F D E + FR I R L Sbjct: 192 EYDGKVADVWSCGVTLYVMLVGAYPFE-DPEEPKNFRKTIHRILNV-------------- 236 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 ++A D+ + P + R L+S++ DP KRIS H +F Sbjct: 237 ------QYAIPDYVHISP----ECRHLISRIFVADPAKRISIPEIRNHEWF 277 >2JD5-A nrPDB Length = 373 Score = 97.8 bits (242), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 94/335 (28%), Positives = 144/335 (42%), Gaps = 70/335 (20%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN---- 62 V K+G G + V+ A++ + VA+K +R D + A EI LL+ +N + Sbjct: 24 VRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGD---KVYTEAAEDEIKLLQRVNDADNTKE 80 Query: 63 -------IVKLLDVIHTEN----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQL 111 I+KLLD + + + +VFE L ++L + GIPL +K QL Sbjct: 81 DSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQL 140 Query: 112 LQGLAFCHSH-RVLHRDLKPQNLLINTEGA------IKLADFGLARAFGVPVRTYTHEVV 164 L GL + H ++H D+KP+N+L+ + IK+AD G A + YT+ + Sbjct: 141 LLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYD---EHYTNSIQ 197 Query: 165 TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDS------EIDQLFRIFRT 218 T YR+PE+LLG + DIWS C+ E++T LF D + D + +I Sbjct: 198 TREYRSPEVLLGAP-WGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIEL 256 Query: 219 LGTPDEVVWPGVTSMPDYKPSFPKWARQDFS-----------KVVPPLD----------- 256 LG +P Y K+ R F+ K P D Sbjct: 257 LG-----------ELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKD 305 Query: 257 --EDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 ++ LS ML DP KR A + HP+ +D Sbjct: 306 EAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKDT 340 >4TPT-A nrPDB Length = 303 Score = 97.8 bits (242), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 67/217 (30%), Positives = 112/217 (51%), Gaps = 38/217 (17%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKK-IRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 E +G+G +G K +K TG+V+ +K+ IR D ET+ T + E+ +++ L+HPN++K Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQ---KTFLTEVKVMRSLDHPNVLKF 62 Query: 67 LDVIHTENKLYLVFEFLH----QDLKKFMDASALTGIPLPLIKSYLFQ--LLQGLAFCHS 120 + V++ + KL L+ E++ +D + MD P P + F + G+A+ HS Sbjct: 63 IGVLYKDKKLNLLTEYIEGGTLKDFLRSMD-------PFPWQQKVRFAKGIASGMAYLHS 115 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAF-----GVPVRTYTHEVVTL--------- 166 ++HRDL N LI + + +ADFGL+R P+ T + TL Sbjct: 116 MCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRY 175 Query: 167 ------WYRAPEILLGCKYYSTAVDIWSLGCIFAEMV 197 ++ APE+L G K Y VDI+S G + E++ Sbjct: 176 TVVGNPYWMAPEMLNG-KSYDETVDIFSFGIVLCEII 211 >1KOB-A nrPDB Length = 387 Score = 97.4 bits (241), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 77/299 (25%), Positives = 138/299 (46%), Gaps = 39/299 (13%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 +E++G G +GVV++ K TG V K I +T T EIS++ +L+HP ++ L Sbjct: 56 LEELGSGAFGVVHRCVEKATGRVFVAKFI--NTPYPLDKYTVKNEISIMNQLHHPKLINL 113 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 D + ++ L+ EFL A+ + + +Y+ Q +GL H H ++H Sbjct: 114 HDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSIVHL 173 Query: 127 DLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL--LGCKYYST 182 D+KP+N++ T+ A +K+ DFGLA P T + APEI+ +Y+ Sbjct: 174 DIKPENIMCETKKASSVKIIDFGLATKLN-PDEIVKVTTATAEFAAPEIVDREPVGFYT- 231 Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPK 242 D+W++G + +++ + F G+ +++ L + R DE Sbjct: 232 --DMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDE------------------ 271 Query: 243 WARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ----DVTKPVPHLR 297 FS V P + + + +L +P KR++ AL HP+ + ++T +P R Sbjct: 272 ---DAFSSVSP----EAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDHSNLTSRIPSSR 323 >1PHK-A nrPDB Length = 298 Score = 97.1 bits (240), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 85/310 (27%), Positives = 140/310 (45%), Gaps = 43/310 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD-------TETEGVPSTAIREISL 54 EN++ E +G G VV + +K T + A+K I + E + + ++E+ + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 55 LKELN-HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQ 113 L++++ HPNI++L D T +LVF+ + + + F + + + + LL+ Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKG-ELFDYLTEKVTLSEKETRKIMRALLE 135 Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 173 + H ++HRDLKP+N+L++ + IKL DFG + P T Y APEI Sbjct: 136 VICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLD-PGEKLREVCGTPSYLAPEI 194 Query: 174 LLGCKY------YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227 + C Y VD+WS G I ++ F ++ L I Sbjct: 195 -IECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSG--------- 244 Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 +Y+ P+W D+S V + L+S+ L P KR +A+ ALAHPFFQ Sbjct: 245 -------NYQFGSPEW--DDYSDTV-------KDLVSRFLVVQPQKRYTAEEALAHPFFQ 288 Query: 288 D-VTKPVPHL 296 V + V H Sbjct: 289 QYVVEEVRHF 298 >5D9K-A nrPDB Length = 330 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 74/227 (32%), Positives = 120/227 (52%), Gaps = 12/227 (5%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTG----EVVALKKIRLDTETEGVPSTAIREISLLKEL 58 F+ ++ +G+G++G V+ + K++G ++ A+K ++ T E +L E+ Sbjct: 31 QFELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEV 89 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 NHP IVKL TE KLYL+ +FL DL F S +K YL +L L Sbjct: 90 NHPFIVKLHYAFQTEGKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALALDH 147 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLAR-AFGVPVRTYTHEVVTLWYRAPEILLG 176 HS +++RDLKP+N+L++ EG IKL DFGL++ + + Y+ T+ Y APE+ + Sbjct: 148 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSF-CGTVEYMAPEV-VN 205 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRT-LGTP 222 + ++ + D WS G + EM+T F G + + I + LG P Sbjct: 206 RRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP 252 >5FET-A nrPDB Length = 847 Score = 96.3 bits (238), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 87/284 (30%), Positives = 128/284 (45%), Gaps = 39/284 (13%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELNHPNIVKLLD 68 IG GT+G V +K T ALK + + I+ E + E +HP I++L+ Sbjct: 541 IGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRLVR 600 Query: 69 VIHTENKLYLVFEFLHQDLKKFMDASALTGI-PLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 N Y + E + + DA G+ P + YL ++ + + H +++RD Sbjct: 601 TFKDSNCFYFLTELVTGG--ELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNIVYRD 658 Query: 128 LKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIW 187 LKP+N+L++ +G +KL DFG A+ + R YT V T Y APE++LG K Y VDIW Sbjct: 659 LKPENILLDKQGYVKLIDFGCAKK--IQGRAYTL-VGTPHYMAPEVILG-KGYGCTVDIW 714 Query: 188 SLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD 247 +LG E + F D E DQL IFR + T G + PDY Sbjct: 715 ALGVCLYEFICGPLPFGNDQE-DQL-EIFRDILT-------GQLTFPDYVS--------- 756 Query: 248 FSKVVPPLDEDGRSLLSQMLHYDPNKRISA-----KAALAHPFF 286 D+D +L+ ++L P RI K H FF Sbjct: 757 --------DQDSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFF 792 >2JC6-A nrPDB Length = 334 Score = 96.3 bits (238), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 80/286 (27%), Positives = 130/286 (45%), Gaps = 34/286 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 F+ E +G G + V A K TG++ A+K I +G S+ EI++L+++ H NI Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKA-LKGKESSIENEIAVLRKIKHENI 82 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF-QLLQGLAFCHSHR 122 V L D+ + N LYLV + + + D G S L Q+L + + H Sbjct: 83 VALEDIYESPNHLYLVMQLVSGG--ELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 140 Query: 123 VLHRDLKPQNLLI---NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 ++HRDLKP+NLL + E I ++DFGL++ G + T Y APE+ L K Sbjct: 141 IVHRDLKPENLLYYSQDEESKIMISDFGLSKMEG-KGDVMSTACGTPGYVAPEV-LAQKP 198 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 YS AVD WS+G I ++ F +++ +I + +Y+ Sbjct: 199 YSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKA----------------EYEFD 242 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 P W + + + + ++ DPNKR + + A HP+ Sbjct: 243 SPYW---------DDISDSAKDFIRNLMEKDPNKRYTCEQAARHPW 279 >6QAU-A nrPDB Length = 280 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 70/234 (29%), Positives = 115/234 (49%), Gaps = 38/234 (16%) Query: 4 FQKVEKIGEGTYGVVYKARNKL-TGEVVALKKIRLDTETEGVPSTAI---REISLLKELN 59 + K + +G G + VV++ R++ T VA+K I + + + I +EI +LKEL Sbjct: 13 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSI----NKKNLSKSQILLGKEIKILKELQ 68 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 H NIV L DV N ++LV E+ + DL ++ A + I+ +L Q+ + Sbjct: 69 HENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGT--LSEDTIRVFLHQIAAAMRIL 126 Query: 119 HSHRVLHRDLKPQNLLINTEG---------AIKLADFGLARAFGVPVRTYTHEVVTL--- 166 HS ++HRDLKPQN+L++ IK+ADFG AR Y H + Sbjct: 127 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFAR--------YLHSNMMAADL 178 Query: 167 ----WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF 216 Y APE+++ ++Y D+WS+G + + + + F +S D R+F Sbjct: 179 CGSPMYMAPEVIM-SQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD--LRMF 229 >2YCR-A nrPDB Length = 323 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 85/293 (29%), Positives = 138/293 (47%), Gaps = 44/293 (15%) Query: 10 IGEGTYGVVYKARNKLTGEVVALK-----KIRLDTETEGVPSTAIR-EISLLKELNHPNI 63 +G G G V A + T + VA+K K + + E P+ + EI +LK+LNHP I Sbjct: 18 LGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 77 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 +K+ + E+ Y+V E + + F + K Y +Q+L + + H + + Sbjct: 78 IKIKNFFDAED-YYIVLELMEGG-ELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGI 135 Query: 124 LHRDLKPQNLLINTEGA---IKLADFGLARAFGVP--VRTYTHEVVTLWYRAPEIL--LG 176 +HRDLKP+N+L++++ IK+ DFG ++ G +RT T Y APE+L +G Sbjct: 136 IHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCG---TPTYLAPEVLVSVG 192 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRT-LGTPDEVVWPGVTSMPD 235 Y+ AVD WSLG I ++ +P SE RT + D++ +P+ Sbjct: 193 TAGYNRAVDCWSLGVILFICLSG---YPPFSE-------HRTQVSLKDQITSGKYNFIPE 242 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 WA + E L+ ++L DP R + + AL HP+ QD Sbjct: 243 V------WAE---------VSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 280 >2JAM-A nrPDB Length = 304 Score = 95.5 bits (236), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 81/289 (28%), Positives = 135/289 (46%), Gaps = 38/289 (13%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 +E +G G + V+ + +LTG++ ALK I+ S+ EI++LK++ H NIV L Sbjct: 14 MEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD--SSLENEIAVLKKIKHENIVTL 71 Query: 67 LDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 D+ + YLV + + + + ++ T L+ + Q+L + + H + ++ Sbjct: 72 EDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLV---IQQVLSAVKYLHENGIV 128 Query: 125 HRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 HRDLKP+NLL T I + DFGL++ + + T Y APE+ L K YS Sbjct: 129 HRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTA--CGTPGYVAPEV-LAQKPYS 185 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 AVD WS+G I ++ F ++E +LF E + G Y+ P Sbjct: 186 KAVDCWSIGVITYILLCGYPPFYEETE-SKLF----------EKIKEGY-----YEFESP 229 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 W + E + + +L DPN+R + + AL+HP+ T Sbjct: 230 FW---------DDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNT 269 >6DBN-A nrPDB Length = 316 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 105/206 (50%), Gaps = 15/206 (7%) Query: 4 FQKVEKIGEGTYGVV----YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 +++ +GEG +G V Y TGE VA+K ++ ++ + +EI +L+ L Sbjct: 37 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLK-KEIEILRNLY 95 Query: 60 HPNIVKLLDVIHTE--NKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 H NIVK + + N + L+ EFL LK+++ + I L Y Q+ +G+ Sbjct: 96 HENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK-NKINLKQQLKYAVQICKGMD 154 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT----HEVVTLWYRAPE 172 + S + +HRDL +N+L+ +E +K+ DFGL +A YT + WY APE Sbjct: 155 YLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWY-APE 213 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVT 198 L+ K+Y A D+WS G E++T Sbjct: 214 CLMQSKFY-IASDVWSFGVTLHELLT 238 >2RIO-A nrPDB Length = 434 Score = 95.1 bits (235), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 90/326 (27%), Positives = 151/326 (46%), Gaps = 59/326 (18%) Query: 1 MENFQKVEKI-GEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 ++N EKI G G+ G V + G VA+K++ +D A+ EI LL E + Sbjct: 13 LKNLVVSEKILGYGSSGTVV-FQGSFQGRPVAVKRMLID-----FCDIALMEIKLLTESD 66 Query: 60 -HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSY-----LFQLLQ 113 HPN+++ T+ LY+ E + +L+ +++ ++ L L K Y L Q+ Sbjct: 67 DHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIAS 126 Query: 114 GLAFCHSHRVLHRDLKPQNLLINTE---------GA----IKLADFGLARAFGVPVRTYT 160 G+A HS +++HRDLKPQN+L++T GA I ++DFGL + ++ Sbjct: 127 GVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFR 186 Query: 161 HEVV----TLWYRAPEILLGCKYYST------AVDIWSLGCIFAEMVTRRALFPGDSEID 210 + T +RAPE+L T ++DI+S+GC+F ++++ GD Sbjct: 187 TNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKY-- 244 Query: 211 QLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYD 270 + + + G+ S+ + K D S + D L+SQM+ +D Sbjct: 245 ----------SRESNIIRGIFSLDEMK------CLHDRSLIAEATD-----LISQMIDHD 283 Query: 271 PNKRISAKAALAHPFFQDVTKPVPHL 296 P KR +A L HP F +K + L Sbjct: 284 PLKRPTAMKVLRHPLFWPKSKKLEFL 309 >4M7I-A nrPDB Length = 299 Score = 94.7 bits (234), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 69/238 (28%), Positives = 119/238 (50%), Gaps = 33/238 (13%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 + +F+ ++ +G G +GVV++A+NK+ A+K+IRL E +RE+ L +L H Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNR-ELAREKVMREVKALAKLEH 62 Query: 61 PNIVKLLDVIHTEN----------KLYLVFEFL---HQDLKKFMDASALTGIPLPLIKSY 107 P IV+ + +N K+YL + ++LK +M+ + + Sbjct: 63 PGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLH 122 Query: 108 LF-QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG---------VPVR 157 +F Q+ + + F HS ++HRDLKP N+ + +K+ DFGL A P+ Sbjct: 123 IFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 182 Query: 158 TY---THEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQL 212 Y T +V T Y +PE + G YS VDI+SLG I E+ L+P ++++++ Sbjct: 183 AYARHTGQVGTKLYMSPEQIHG-NSYSHKVDIFSLGLILFEL-----LYPFSTQMERV 234 >3UC3-A nrPDB Length = 361 Score = 94.7 bits (234), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 63/193 (32%), Positives = 100/193 (51%), Gaps = 11/193 (5%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + + V+ IG G +GV R+KLT E+VA+K I + REI + L HP Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE---RGAAIDENVQREIINHRSLRHP 76 Query: 62 NIVKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 NIV+ +VI T L ++ E+ + ++ +A + + + QLL G+++CH Sbjct: 77 NIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSE---DEARFFFQQLLSGVSYCH 133 Query: 120 SHRVLHRDLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 S ++ HRDLK +N L++ A +K+ DFG +++ V V T Y APE+LL Sbjct: 134 SMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPEVLLRQ 192 Query: 178 KYYSTAVDIWSLG 190 +Y D+WS G Sbjct: 193 EYDGKIADVWSCG 205 >2W1I-A nrPDB Length = 326 Score = 94.4 bits (233), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 66/203 (32%), Positives = 104/203 (51%), Gaps = 16/203 (7%) Query: 7 VEKIGEGTYGVVYKAR----NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 ++++G+G +G V R TGEVVA+KK++ TE REI +LK L H N Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEH--LRDFEREIEILKSLQHDN 103 Query: 63 IVKLLDVIHTENK--LYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 IVK V ++ + L L+ E+L + L+ ++ + L++ Y Q+ +G+ + Sbjct: 104 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQ-YTSQICKGMEYLG 162 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT----HEVVTLWYRAPEILL 175 + R +HRDL +N+L+ E +K+ DFGL + Y E WY APE L Sbjct: 163 TKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APESLT 221 Query: 176 GCKYYSTAVDIWSLGCIFAEMVT 198 K +S A D+WS G + E+ T Sbjct: 222 ESK-FSVASDVWSFGVVLYELFT 243 >3NYO-A nrPDB Length = 576 Score = 94.4 bits (233), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 83/296 (28%), Positives = 139/296 (46%), Gaps = 36/296 (12%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGV-PSTAIREISLLKELNHP 61 F++ +G+G +G V + + TG++ A KK+ + + A+ E +L+++N Sbjct: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +V L T++ L LV ++ DLK + G P Y ++ GL H Sbjct: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV-RTYTHEVVTLWYRAPEILLGCKY 179 R+++RDLKP+N+L++ G I+++D GL A VP +T V T+ Y APE++ + Sbjct: 305 ERIVYRDLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGTVGYMAPEVVKN-ER 361 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 Y+ + D W+LGC+ EM+ G S Q R E V V +P+ Sbjct: 362 YTFSPDWWALGCLLYEMIA------GQSPFQQ-----RKKKIKREEVERLVKEVPE---- 406 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA-----HPFFQDVT 290 ++S+ P RSL SQ+L DP +R+ + A HP F+ + Sbjct: 407 -------EYSERFSP---QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 >3IO7-A nrPDB Length = 313 Score = 94.0 bits (232), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 66/203 (32%), Positives = 104/203 (51%), Gaps = 16/203 (7%) Query: 7 VEKIGEGTYGVVYKAR----NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 ++++G+G +G V R TGEVVA+KK++ TE REI +LK L H N Sbjct: 33 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEH--LRDFEREIEILKSLQHDN 90 Query: 63 IVKLLDVIHTENK--LYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 IVK V ++ + L L+ E+L + L+ ++ + L++ Y Q+ +G+ + Sbjct: 91 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQ-YTSQICKGMEYLG 149 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT----HEVVTLWYRAPEILL 175 + R +HRDL +N+L+ E +K+ DFGL + Y E WY APE L Sbjct: 150 TKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APESLT 208 Query: 176 GCKYYSTAVDIWSLGCIFAEMVT 198 K +S A D+WS G + E+ T Sbjct: 209 ESK-FSVASDVWSFGVVLYELFT 230 >3I6U-A nrPDB Length = 419 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 85/293 (29%), Positives = 139/293 (47%), Gaps = 44/293 (15%) Query: 10 IGEGTYGVVYKARNKLTGEVVALK-----KIRLDTETEGVPSTAIR-EISLLKELNHPNI 63 +G G G V A + T + VA++ K + + E P+ + EI +LK+LNHP I Sbjct: 143 LGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 202 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 +K+ + E+ Y+V E L + + F + K Y +Q+L + + H + + Sbjct: 203 IKIKNFFDAED-YYIVLE-LMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGI 260 Query: 124 LHRDLKPQNLLINTEGA---IKLADFGLARAFGVP--VRTYTHEVVTLWYRAPEIL--LG 176 +HRDLKP+N+L++++ IK+ DFG ++ G +RT T Y APE+L +G Sbjct: 261 IHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCG---TPTYLAPEVLVSVG 317 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRT-LGTPDEVVWPGVTSMPD 235 Y+ AVD WSLG I ++ +P SE RT + D++ +P+ Sbjct: 318 TAGYNRAVDCWSLGVILFICLSG---YPPFSE-------HRTQVSLKDQITSGKYNFIPE 367 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 WA + E L+ ++L DP R + + AL HP+ QD Sbjct: 368 V------WAE---------VSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 >5VD3-A nrPDB Length = 311 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 81/288 (28%), Positives = 123/288 (42%), Gaps = 35/288 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-H 60 ++FQ++ ++G G+YG V+K R+K G + A+K+ + + E+ +++ H Sbjct: 57 QSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQH 116 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 P V+L LYL E L++ +A + +P + YL L LA HS Sbjct: 117 PCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGAS-LPEAQVWGYLRDTLLALAHLHS 175 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 ++H D+KP N+ + G KL DFGL G E Y APE+L G Y Sbjct: 176 QGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPR-YMAPELLQGS--Y 232 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 TA D++SLG E+ L G QL + + +P P F Sbjct: 233 GTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGY----------------LP---PEF 273 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 L + RS+L ML DP R +A+A LA P + Sbjct: 274 -----------TAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ 310 >2W4O-A nrPDB Length = 349 Score = 93.6 bits (231), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 86/290 (29%), Positives = 137/290 (47%), Gaps = 37/290 (12%) Query: 1 MENFQKVE-KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 + +F +VE ++G G +VY+ + K T + ALK ++ + + V + EI +L L+ Sbjct: 51 LSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRT----EIGVLLRLS 106 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPL-IKSYLFQLLQGLAFC 118 HPNI+KL ++ T ++ LV E + + D G + Q+L+ +A+ Sbjct: 107 HPNIIKLKEIFETPTEISLVLELVTGG--ELFDRIVEKGYYSERDAADAVKQILEAVAYL 164 Query: 119 HSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 H + ++HRDLKP+NLL T + +K+ADFGL++ V T T Y APEIL Sbjct: 165 HENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKT-VCGTPGYCAPEILR 223 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 GC Y VD+WS+G I ++ F D DQ F R L + Sbjct: 224 GCA-YGPEVDMWSVGIITYILLCGFEPFY-DERGDQ-FMFRRILNC-------------E 267 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 Y P W + + L+ +++ DP KR++ AL HP+ Sbjct: 268 YYFISPWWDEVSL---------NAKDLVRKLIVLDPKKRLTTFQALQHPW 308 >5DYK-A nrPDB Length = 853 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 91/298 (30%), Positives = 132/298 (44%), Gaps = 45/298 (15%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELN 59 M+ + IG GT+G V +K T ALK + + I+ E + E + Sbjct: 538 MDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAEND 597 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKS----YLFQLLQGL 115 HP I++L+ Y + E + + DA G+ L KS YL ++ + Sbjct: 598 HPFIIRLVRTFKDSKYFYFLTELVTG--GELYDAIRKLGL---LSKSQAQFYLGSIILAI 652 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 + H +++RDLKP+N+L++ +G +KL DFG A+ V R YT V T Y APE++L Sbjct: 653 EYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKK--VQGRAYTL-VGTPHYMAPEVIL 709 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 G K Y VDIW+LG E + F D E DQL IFR + T G + PD Sbjct: 710 G-KGYGCTVDIWALGICLYEFICGPLPFGNDEE-DQL-EIFRDILT-------GQLTFPD 759 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA-----KAALAHPFFQD 288 Y D D +L+ ++L P RI K HPFF + Sbjct: 760 Y-----------------VTDTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSN 800 >6CCF-A nrPDB Length = 290 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 79/313 (25%), Positives = 134/313 (42%), Gaps = 57/313 (18%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-----------------RLDTETEG 43 + ++ +IG+G YGVV A N+ A+K + R +G Sbjct: 4 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 63 Query: 44 VPSTAI-------REISLLKELNHPNIVKLLDVIH--TENKLYLVFEFLHQDLKKFMDAS 94 P+ + +EI++LK+L+H N+VKL++V+ E+ LYLVF+ L + M+ Sbjct: 64 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRK--GPVMEVP 121 Query: 95 ALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV 154 + YL ++ GL + H +++HRD+KP NLL+ +G +K+ADFG++ F Sbjct: 122 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG 181 Query: 155 PVRTYTHEVVTLWYRAPEIL--LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQL 212 + T + APE + G + A+D+W+ G V + F ID Sbjct: 182 NDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF-----IDDF 236 Query: 213 FRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPN 272 + VV+P P + E+ + L+ +ML +P Sbjct: 237 ILALHRKIKNEPVVFPE----------------------EPEISEELKDLILKMLDKNPE 274 Query: 273 KRISAKAALAHPF 285 RI HP+ Sbjct: 275 TRIGVPDIKLHPW 287 >3HKO-A nrPDB Length = 345 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 88/335 (26%), Positives = 141/335 (42%), Gaps = 78/335 (23%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKL 66 IG+G+YGVV A T + A+K + + + P R E+ L+K+L+HPNI +L Sbjct: 34 IGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPNIARL 93 Query: 67 LDVIHTENKLYLVFEFLH-----QDLKKFMDASALTG-----------IPLP-------- 102 +V E + LV E H L F+D S TG P P Sbjct: 94 YEVYEDEQYICLVMELCHGGHLLDKLNVFIDDS--TGKCAMDVVKTQICPCPECNEEAIN 151 Query: 103 -----------------LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA--IKL 143 LI + + Q+ L + H+ + HRD+KP+N L +T + IKL Sbjct: 152 GSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKL 211 Query: 144 ADFGLARAF----GVPVRTYTHEVVTLWYRAPEIL-LGCKYYSTAVDIWSLGCIFAEMVT 198 DFGL++ F T + T ++ APE+L + Y D WS G + ++ Sbjct: 212 VDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLHLLLM 271 Query: 199 RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDED 258 FPG ++ D + ++ ++ + P+Y V+ PL Sbjct: 272 GAVPFPGVNDADTISQVLNK-----KLCFEN----PNY-------------NVLSPL--- 306 Query: 259 GRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293 R LLS +L+ + ++R A AL HP+ + + Sbjct: 307 ARDLLSNLLNRNVDERFDAMRALQHPWISQFSDKI 341 >2J90-A nrPDB Length = 304 Score = 92.8 bits (229), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 77/300 (25%), Positives = 144/300 (48%), Gaps = 40/300 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVA---LKKIRLDTETEGVPSTAI-REISLLKE 57 ++++ E++G G + +V K R K TG+ A +KK RL + GV I RE+++L+E Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 85 Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFM-DASALTGIPLPLIKSYLFQLLQGL 115 + HPNI+ L D+ + + L+ E + +L F+ + +LT +L Q+L G+ Sbjct: 86 IRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEAT---QFLKQILDGV 142 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTHEVVTLWYRAP 171 + HS R+ H DLKP+N+++ + IKL DFG+A + + T + AP Sbjct: 143 HYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAG-NEFKNIFGTPEFVAP 201 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT 231 EI + + D+WS+G I +++ + F G+++ + L I DE + + Sbjct: 202 EI-VNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTS 260 Query: 232 SMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 + +DF + ++L DP +R++ +L H + + + + Sbjct: 261 ELA-----------KDF--------------IRRLLVKDPKRRMTIAQSLEHSWIKAIRR 295 >3VN9-A nrPDB Length = 340 Score = 92.8 bits (229), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 63/212 (29%), Positives = 104/212 (49%), Gaps = 9/212 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++ + + ++G G YGVV K R+ +G+++A+K+IR ++ + ++ ++ P Sbjct: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG--IPLPLIKSYLFQLLQGLAFCH 119 V + E +++ E + L KF G IP ++ +++ L H Sbjct: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 Query: 120 SH-RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL---L 175 S V+HRD+KP N+LIN G +K+ DFG++ + V T + Y APE + L Sbjct: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGIS-GYLVDSVAKTIDAGCKPYMAPERINPEL 229 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDS 207 K YS DIWSLG E+ R FP DS Sbjct: 230 NQKGYSVKSDIWSLGITMIELAILR--FPYDS 259 >6FYV-A nrPDB Length = 337 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 92/332 (27%), Positives = 142/332 (42%), Gaps = 64/332 (19%) Query: 4 FQKVEKIGEGTYG-VVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELNH- 60 ++ V+ +GEG +G VV + + G VA+K ++ G A R EI +L+ LN Sbjct: 16 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVK----NVGRYREAARSEIQVLEHLNST 71 Query: 61 -PN----IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 PN V++L+ + +VFE L F+ ++ + I+ +Q+ Q + Sbjct: 72 DPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSI 131 Query: 116 AFCHSHRVLHRDLKPQNLLI---------------------NTEGAIKLADFGLARAFGV 154 F H +++ H DLKP+N+L NT+ IK+ DFG A Sbjct: 132 NFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTD--IKVVDFGSA----- 184 Query: 155 PVRTYTHE-----VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209 TY E V T YRAPE++L +S D+WS+GCI E +F Sbjct: 185 ---TYDDEHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEYYLGFTVFQTHDSK 240 Query: 210 DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW-----ARQDFSKVVPPL-------DE 257 + L + R LG + + + + W A + + PL DE Sbjct: 241 EHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDE 300 Query: 258 DGRSLLS---QMLHYDPNKRISAKAALAHPFF 286 + L +ML YDP +RI+ AL HPFF Sbjct: 301 EHEKLFDLVRRMLEYDPTQRITLDEALQHPFF 332 >3KN6-A nrPDB Length = 325 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 83/297 (27%), Positives = 129/297 (43%), Gaps = 51/297 (17%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKI--RLDTETEGVPSTAIREISLLKEL-NHPNIVKL 66 +GEG++ + K +K + + A+K I R++ T+ +EI+ LK HPNIVKL Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQ-------KEITALKLCEGHPNIVKL 71 Query: 67 LDVIHTENKLYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYLF-QLLQGLAF 117 +V H + +LV E L+ + K F + A SY+ +L+ ++ Sbjct: 72 HEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEA----------SYIMRKLVSAVSH 121 Query: 118 CHSHRVLHRDLKPQNLLINTEG---AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 H V+HRDLKP+NLL E IK+ DFG AR + TL Y APE L Sbjct: 122 MHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-L 180 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 L Y + D+WSLG I M++ + F R+L V Sbjct: 181 LNQNGYDESCDLWSLGVILYTMLSGQVPFQSHD---------RSLTCTSAVEIMKKIKKG 231 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 D+ W + ++ + L+ +L DPNKR+ + + QD ++ Sbjct: 232 DFSFEGEAWKN---------VSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQ 279 >4WB7-A nrPDB Length = 405 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 67/211 (31%), Positives = 112/211 (53%), Gaps = 8/211 (3%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD--TETEGVPSTAIREISLLKEL 58 ++ F++++ +G G++G V ++K TG A+K + + + + T + E +L+ + Sbjct: 95 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHT-LNEKRILQAV 153 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 N P +VKL + LY+V E++ + F + P + Y Q++ + Sbjct: 154 NFPFLVKLEFSFKDNSNLYMVMEYVPGG-EMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 212 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 HS +++RDLKP+NLLI+ +G I++ DFG A+ V RT+T T Y APEI+L K Sbjct: 213 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPEIIL-SK 268 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209 Y+ AVD W+LG + EM F D I Sbjct: 269 GYNKAVDWWALGVLIYEMAAGYPPFFADQPI 299 >5LOH-A nrPDB Length = 341 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 84/297 (28%), Positives = 133/297 (44%), Gaps = 39/297 (13%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR-LDTETEGVPSTAIREISLLKELN 59 +E F V+ I G +G VY + G++ A+K ++ D + + E L Sbjct: 35 IEEFSIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALSK 92 Query: 60 HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 P IV L + + N +YLV E+L D+K + + + Y+ ++ L + Sbjct: 93 SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAV--KYISEVALALDYL 150 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF------GVPVRTYTHEVVTLWYRAPE 172 H H ++HRDLKP N+LI+ EG IKL DFGL++ + + T T Y APE Sbjct: 151 HRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPE 210 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 +LLG + + AVD W+LG E +T + P + E Q ++F+ + D + WP Sbjct: 211 LLLG-RAHGPAVDWWALGVCLFEFLT--GIPPFNDETPQ--QVFQNILKRD-IPWP---- 260 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 + L ++ +S + +L D KR K HP F DV Sbjct: 261 -----------------EGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDV 300 >3A8W-A nrPDB Length = 345 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 82/300 (27%), Positives = 135/300 (45%), Gaps = 36/300 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR--LDTETEGVPSTAIREISLLKEL 58 +++F + IG G+Y V R K T + A+K ++ L + E + + + Sbjct: 8 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 67 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 NHP +V L TE++L+ V E+++ DL M +P + Y ++ L + Sbjct: 68 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQ--RKLPEEHARFYSAEISLALNY 125 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 H +++RDLK N+L+++EG IKL D+G+ + P T + T Y APEIL G Sbjct: 126 LHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG- 184 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY- 236 + Y +VD W+LG + EM+ R+ F I + PD+ + DY Sbjct: 185 EDYGFSVDWWALGVLMFEMMAGRSPFD----------IVGSSDNPDQ-------NTEDYL 227 Query: 237 -KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL------AHPFFQDV 289 + K R + L S+L L+ DP +R+ HPFF++V Sbjct: 228 FQVILEKQIR-----IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNV 282 >5D7A-A nrPDB Length = 308 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 67/210 (31%), Positives = 104/210 (49%), Gaps = 23/210 (10%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH-PN 62 F+ VE +G GTYG VYK R+ TG++ A+K + + + E +EI++LK+ +H N Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE---EEIKQEINMLKKYSHHRN 75 Query: 63 IVKLLDVIHTEN------KLYLVFEFLHQ----DLKKFMDASALTGIPLPLIKSYLFQLL 112 I +N +L+LV EF DL K + L + I ++L Sbjct: 76 IATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI---CREIL 132 Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 +GL+ H H+V+HRD+K QN+L+ +KL DFG++ V + T ++ APE Sbjct: 133 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 192 Query: 173 ILLGCK-----YYSTAVDIWSLGCIFAEMV 197 + + C Y D+WSLG EM Sbjct: 193 V-IACDENPDATYDFKSDLWSLGITAIEMA 221 >2JDO-A nrPDB Length = 342 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 83/306 (27%), Positives = 142/306 (46%), Gaps = 50/306 (16%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLKEL 58 M +F ++ +G+GT+G V R K TG A+K +R + + V T + E +L+ Sbjct: 9 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHT-VTESRVLQNT 67 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HP + L T ++L V E+ + + F S + Y +++ L + Sbjct: 68 RHPFLTALKYAFQTHDRLCFVMEYANGG-ELFFHLSRERVFTEERARFYGAEIVSALEYL 126 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLAR---AFGVPVRTYTHEVVTLWYRAPEILL 175 HS V++RD+K +NL+++ +G IK+ DFGL + + G ++T+ T Y APE+L Sbjct: 127 HSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCG---TPEYLAPEVLE 183 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 Y AVD W LG + EM+ R F + + ++LF + +E+ +P Sbjct: 184 DND-YGRAVDWWGLGVVMYEMMCGRLPFY-NQDHERLFELILM----EEIRFP------- 230 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF---- 286 + + P + +SLL+ +L DP +R+ AK + H FF Sbjct: 231 --------------RTLSP---EAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSIN 273 Query: 287 -QDVTK 291 QDV + Sbjct: 274 WQDVVQ 279 >1FOT-A nrPDB Length = 318 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 73/297 (24%), Positives = 141/297 (47%), Gaps = 44/297 (14%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD--TETEGVPSTAIREISLLKEL 58 +++FQ + +G G++G V+ R++ G A+K ++ + + V T + +L + Sbjct: 5 LQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERL-MLSIV 63 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 HP I+++ +++++ +++ +L + S P P+ K Y ++ L + Sbjct: 64 THPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQR--FPNPVAKFYAAEVCLALEY 121 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 HS +++RDLKP+N+L++ G IK+ DFG A+ VP TYT T Y APE+ + Sbjct: 122 LHSKDIIYRDLKPENILLDKNGHIKITDFGFAKY--VPDVTYTL-CGTPDYIAPEV-VST 177 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 K Y+ ++D WS G + EM+ F + + +I E+ +P Sbjct: 178 KPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNA-----ELRFP--------- 223 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDV 289 P +ED + LLS+++ D ++R+ + HP+F++V Sbjct: 224 ---------------PFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEV 265 >4CSV-A nrPDB Length = 275 Score = 90.9 bits (224), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 67/253 (26%), Positives = 122/253 (48%), Gaps = 30/253 (11%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTA--IREISLLKELNHPNIVKL 66 K+G G +G VY+ + + VA+K ++ EG S ++E ++K+L HPN+V+L Sbjct: 18 KLGSGQFGEVYEGKWRNYNIEVAVKTLK-----EGTMSVEEFLQEAQIMKKLKHPNLVQL 72 Query: 67 LDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 125 V E +Y++ E++ H L ++ + + Q+ G+A+ S +H Sbjct: 73 YGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFIH 132 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT---LWYRAPEILLGCKYYST 182 RDL +N L+ +K+ADFGLAR + YT + + APE + +S Sbjct: 133 RDLAARNCLVGENNVVKVADFGLARL--INEDEYTARAGAKFPIKWTAPEA-ISYNRFSI 189 Query: 183 AVDIWSLGCIFAEMVTRRAL-FPGDS------EIDQLFRIFRTLGTPDEV------VWPG 229 D+W+ G + E+ T + +PG S ++++ +R+ R G P+E+ W Sbjct: 190 KSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIYELMLQCW-- 247 Query: 230 VTSMPDYKPSFPK 242 P+ +P+F + Sbjct: 248 -NKSPEERPTFAE 259 >5X3F-B nrPDB Length = 393 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 66/211 (31%), Positives = 111/211 (52%), Gaps = 8/211 (3%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD--TETEGVPSTAIREISLLKEL 58 ++ F +++ +G G++G V ++K +G A+K + + + + T + E +L+ + Sbjct: 83 LDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHT-LNEKRILQAV 141 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 N P +VKL + LY+V E++ + F + P + Y Q++ + Sbjct: 142 NFPFLVKLEFSFKDNSNLYMVMEYVAGG-EMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 200 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 HS +++RDLKP+NLLI+ +G I++ DFG A+ V RT+T T Y APEI+L K Sbjct: 201 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPEIIL-SK 256 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209 Y+ AVD W+LG + EM F D I Sbjct: 257 GYNKAVDWWALGVLIYEMAAGYPPFFADQPI 287 >3DAK-A nrPDB Length = 290 Score = 90.5 bits (223), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 81/299 (27%), Positives = 134/299 (44%), Gaps = 34/299 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++++ E IG G VV A E VA+K+I L+ + + ++EI + + +HP Sbjct: 10 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLE-KCQTSMDELLKEIQAMSQCHHP 68 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ----DLKKFMDASA--LTGI-PLPLIKSYLFQLLQG 114 NIV +++L+LV + L D+ K + A +G+ I + L ++L+G Sbjct: 69 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 128 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF----GVPVRTYTHE--VVTLWY 168 L + H + +HRD+K N+L+ +G++++ADFG++ AF G R + V T + Sbjct: 129 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVS-AFLATGGDITRNKVRKTFVGTPCW 187 Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228 APE++ + Y DIWS G E+ T A + + L + E Sbjct: 188 MAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQ 247 Query: 229 GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 + Y SF R ++S L DP KR +A L H FFQ Sbjct: 248 DKEMLKKYGKSF-------------------RKMISLCLQKDPEKRPTAAELLRHKFFQ 287 >5DBX-A nrPDB Length = 328 Score = 90.5 bits (223), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 84/296 (28%), Positives = 135/296 (45%), Gaps = 40/296 (13%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 E IG G VV A K E VA+K+I L+ + + ++EI + + +HPN+V Sbjct: 17 EVIGSGATAVVQAALCKPRQERVAIKRINLE-KCQTSMDELLKEIQAMSQCSHPNVVTYY 75 Query: 68 DVIHTENKLYLVFEFLHQ----DLKKFM--DASALTGI-PLPLIKSYLFQLLQGLAFCHS 120 +++L+LV + L D+ K++ G+ +I + L ++L+GL + H Sbjct: 76 TSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHR 135 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAF----GVPVRTYTHE--VVTLWYRAPEIL 174 + +HRDLK N+L+ +G++++ADFG++ AF G R + V T + APE++ Sbjct: 136 NGQIHRDLKAGNILLGEDGSVQIADFGVS-AFLATGGDVTRNKVRKDFVGTPCWMAPEVM 194 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS-- 232 + Y D+WS G E+ T A + + + + TL + GV Sbjct: 195 EQVRGYDFKADMWSFGITAIELATGAAPY---HKYPPMKVLMLTLQNDPPTLETGVEDKE 251 Query: 233 -MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 M Y SF R LLS L DP+KR +A L FFQ Sbjct: 252 MMKKYGKSF-------------------RKLLSLCLQKDPSKRPTAAELLKCKFFQ 288 >5N23-A nrPDB Length = 352 Score = 90.5 bits (223), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 67/211 (31%), Positives = 108/211 (51%), Gaps = 7/211 (3%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD--TETEGVPSTAIREISLLKEL 58 ++ F+++ +G G++G V ++K TG A+K + + + + T + E + + + Sbjct: 41 LDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHT-LNEKRIQQAV 99 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 N P +VKL + LY+V E+ + F + P + Y Q++ + Sbjct: 100 NFPFLVKLEFSFKDNSNLYMVLEYAPGG-EMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 HS +++RDLKP+NLLI+ +G IK+ADFG A+ V RT T Y APEI+L K Sbjct: 159 HSLDLIYRDLKPENLLIDQQGYIKVADFGFAKR--VKGRTPWTLCGTPEYLAPEIIL-SK 215 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209 Y+ AVD W+LG + EM F D I Sbjct: 216 GYNKAVDWWALGVLIYEMAAGYPPFFADQPI 246 >3FME-A nrPDB Length = 290 Score = 90.5 bits (223), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 63/214 (29%), Positives = 104/214 (48%), Gaps = 13/214 (6%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++ + + ++G G YGVV K R+ +G+++A+K+IR ++ + ++ ++ P Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 66 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG--IPLPLIKSYLFQLLQGLAFCH 119 V + E +++ E + L KF G IP ++ +++ L H Sbjct: 67 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 126 Query: 120 SH-RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW--YRAPEIL-- 174 S V+HRD+KP N+LIN G +K+ DFG++ G V ++ Y APE + Sbjct: 127 SKLSVIHRDVKPSNVLINALGQVKMCDFGIS---GYLVDDVAKDIDAGCKPYMAPERINP 183 Query: 175 -LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDS 207 L K YS DIWSLG E+ R FP DS Sbjct: 184 ELNQKGYSVKSDIWSLGITMIELAILR--FPYDS 215 >3A4O-X nrPDB Length = 286 Score = 90.1 bits (222), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 66/236 (27%), Positives = 120/236 (50%), Gaps = 20/236 (8%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E+ + V+++G G +G V+ + +V A+K ++ T + + E +L+K L H Sbjct: 13 ESIKLVKRLGAGQFGEVWMGYYNNSTKV-AVKTLKPGTMS---VQAFLEEANLMKTLQHD 68 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +V+L V+ E +Y++ E++ + L F+ + + LP + + Q+ +G+A+ Sbjct: 69 KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER 128 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT---LWYRAPE-ILLG 176 +HRDL+ N+L++ K+ADFGLAR + YT + + APE I G Sbjct: 129 KNYIHRDLRAANVLVSESLMCKIADFGLARV--IEDNEYTAREGAKFPIKWTAPEAINFG 186 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRAL-FPGDSEID------QLFRIFRTLGTPDEV 225 C ++ D+WS G + E+VT + +PG + D Q +R+ R PDE+ Sbjct: 187 C--FTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 240 >4JG6-A nrPDB Length = 355 Score = 90.1 bits (222), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 85/302 (28%), Positives = 131/302 (43%), Gaps = 59/302 (19%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ E IG G+Y V + +K T A+K I +++ P+ I EI LL+ HP Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKII---DKSKRDPTEEI-EI-LLRYGQHP 89 Query: 62 NIVKLLDVIHTENKLYLVFEF----------LHQDLKKFMDASALTGIPLPLIKSYLFQL 111 NI+ L DV +Y+V E L Q +ASA+ LF + Sbjct: 90 NIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAV-----------LFTI 138 Query: 112 LQGLAFCHSHRVLHRDLKPQNLLINTEG----AIKLADFGLARAFGVPVRTYTHEVVTLW 167 + + + H+ V+HRDLKP N+L E +I++ DFG A+ T Sbjct: 139 TKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTAN 198 Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALF---PGDSEIDQLFRIFRTLGTPDE 224 + APE+L + Y A DIWSLG + M+T F P D+ + L RI + Sbjct: 199 FVAPEVLER-QGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSG 257 Query: 225 VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284 W V+ + + L+S+MLH DP++R++A L HP Sbjct: 258 GYWNSVS-------------------------DTAKDLVSKMLHVDPHQRLTAALVLRHP 292 Query: 285 FF 286 + Sbjct: 293 WI 294 >6HV0-A nrPDB Length = 416 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 88/294 (29%), Positives = 131/294 (44%), Gaps = 45/294 (15%) Query: 10 IGEGTYG-VVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVKLL 67 +G G G +VY R VA+K+I + S A RE+ LL+E + HPN+++ Sbjct: 16 LGHGAEGTIVY--RGMFDNRDVAVKRILPE-----CFSFADREVQLLRESDEHPNVIRYF 68 Query: 68 DVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 Y+ E L+++++ + L I + L Q GLA HS ++HRD Sbjct: 69 CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPI-TLLQQTTSGLAHLHSLNIVHRD 127 Query: 128 LKPQNLLI---NTEGAIK--LADFGLARAFGVPVRTYTHEV---VTLWYRAPEILL-GCK 178 LKP N+LI N G IK ++DFGL + V +++ T + APE+L CK Sbjct: 128 LKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCK 187 Query: 179 YYST-AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 T VDI+S GC+F +++ + G S Q + G S+ Sbjct: 188 ENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ------------ANILLGACSLDCLH 235 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 P + D R L+ +M+ DP KR SAK L HPFF + K Sbjct: 236 PEKHE-------------DVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEK 276 >4FZF-B nrPDB Length = 283 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 84/300 (28%), Positives = 141/300 (47%), Gaps = 42/300 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E F K+E+IG+G++G V+K + T +VVA+K I L+ + + +EI++L + + Sbjct: 8 ELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ-QEITVLSQCDSS 66 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGI---PLP--LIKSYLFQLLQGLA 116 + K +KL+++ E+L SAL + P I + L ++L+GL Sbjct: 67 YVTKYYGSYLKGSKLWIIMEYLG-------GGSALDLLRAGPFDEFQIATMLKEILKGLD 119 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 + HS + +HRD+K N+L++ +G +KLA FG+A V T ++ APE++ Sbjct: 120 YLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQ 179 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 Y S A DIWSLG E+ P +S++ + +F +P Sbjct: 180 SAYDSKA-DIWSLGITAIELAKGE---PPNSDMHPMRVLFL---------------IPKN 220 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296 P P DF+K + + L+ DP+ R +AK L H F +K +L Sbjct: 221 NP--PTLV-GDFTKSF-------KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYL 270 >4TNB-A nrPDB Length = 590 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 77/296 (26%), Positives = 135/296 (45%), Gaps = 38/296 (12%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHPN 62 F++ +G+G +G V + + TG++ A K++ + + S A+ E +L+++N Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +V L T++ L LV ++ DLK + G Y ++L GL H Sbjct: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHE 305 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKY 179 ++RDLKP+N+L++ G I+++D GLA G +R V T+ Y APE+L + Sbjct: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRG---RVGTVGYMAPEVLNN-QR 361 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 Y + D W LGC+ EM+ ++ F G E + + R + +EV Y Sbjct: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV----------YSHK 411 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA-----HPFFQDVT 290 F E+ +S+ +L D +R+ + A HPFF+++ Sbjct: 412 F---------------SEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMN 452 >3F3Z-A nrPDB Length = 277 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 86/301 (28%), Positives = 131/301 (43%), Gaps = 58/301 (19%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 IG G++G V A K T A KKI E V +EI ++K L+HPNI++L + Sbjct: 17 IGRGSWGEVKIAVQKGTRIRRAAKKIP-KYFVEDVDRFK-QEIEIMKSLDHPNIIRLYET 74 Query: 70 IHTENKLYLVFEF----------LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 +YLV E +H+ + + DA+ + + +L +A+CH Sbjct: 75 FEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARI-----------MKDVLSAVAYCH 123 Query: 120 SHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 V HRDLKP+N L T + +KL DFGLA F P + +V T +Y +P++L G Sbjct: 124 KLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFK-PGKMMRTKVGTPYYVSPQVLEG 182 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALF--PGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 Y D WS G + ++ F P DSE+ R G + P Sbjct: 183 L--YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIR-------------EGTFTFP 227 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 + +D+ V P SL+ ++L P +RI++ AL H +F+ P Sbjct: 228 E----------KDWLNVSP----QAESLIRRLLTKSPKQRITSLQALEHEWFEKQLSSSP 273 Query: 295 H 295 Sbjct: 274 R 274 >4RA4-A nrPDB Length = 355 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 116/227 (51%), Gaps = 27/227 (11%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLKEL 58 + +F + +G+G++G V A K T E+ A+K ++ D + + V T + + L Sbjct: 19 LTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD 78 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYLFQ 110 P + +L T ++LY V E+++ Q + KF + A+ Y + Sbjct: 79 KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVF---------YAAE 129 Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF---GVPVRTYTHEVVTLW 167 + GL F H +++RDLK N+++++EG IK+ADFG+ + GV RT+ T Sbjct: 130 ISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCG---TPD 186 Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR 214 Y APEI + + Y +VD W+ G + EM+ + F G+ E D+LF+ Sbjct: 187 YIAPEI-IAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE-DELFQ 231 >4OLI-A nrPDB Length = 645 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 65/205 (31%), Positives = 102/205 (49%), Gaps = 15/205 (7%) Query: 4 FQKVEKIGEGTYGVV----YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 +K+ +GEG +G V Y N TGE+VA+K ++ D + S +EI +L+ L Sbjct: 355 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHR-SGWKQEIDILRTLY 413 Query: 60 HPNIVKLLDVI--HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 H +I+K E L LV E++ L D I L + + Q+ +G+A+ Sbjct: 414 HEHIIKYKGCCEDQGEKSLQLVMEYV--PLGSLRDYLPRHSIGLAQLLLFAQQICEGMAY 471 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----THEVVTLWYRAPEI 173 HS +HR+L +N+L++ + +K+ DFGLA+A Y + WY APE Sbjct: 472 LHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-APEC 530 Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVT 198 L K+Y A D+WS G E++T Sbjct: 531 LKEYKFY-YASDVWSFGVTLYELLT 554 Score = 35.4 bits (80), Expect = 0.028, Method: Compositional matrix adjust. Identities = 47/194 (24%), Positives = 80/194 (41%), Gaps = 46/194 (23%) Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLI-------NTEGAIKLADFGLARAFGVPVRTYTHE 162 QL L++ + ++H ++ +N+L+ T IKL+D G+ G+ + Sbjct: 175 QLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGV----GLGALSREER 230 Query: 163 VVTLWYRAPEIL-LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGT 221 V + + APE L G STA+D W G E+ F G++ + + Sbjct: 231 VERIPWLAPECLPGGANSLSTAMDKWGFGATLLEIC-----FDGEAPLQS------RSPS 279 Query: 222 PDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281 E + +P+ PS P+ A +L SQ L Y+P +R S + L Sbjct: 280 EKEHFYQRQHRLPE--PSCPQLA----------------TLTSQCLTYEPTQRPSFRTIL 321 Query: 282 AHPFFQDVTKPVPH 295 +D+T+ PH Sbjct: 322 -----RDLTRLQPH 330 >3ORZ-A nrPDB Length = 316 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 82/294 (27%), Positives = 132/294 (44%), Gaps = 32/294 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI--RLDTETEGVPSTAIREISLLKELN 59 E+F+ + +GEG++ V AR T A+K + R + VP RE ++ L+ Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT-RERDVMSRLD 95 Query: 60 HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HP VKL + KLY + + +L K++ + + Y +++ L + Sbjct: 96 HPFFVKLYFCFQDDEKLYFGLSYAKNGELLKYI--RKIGSFDETCTRFYTAEIVSALEYL 153 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE--VVTLWYRAPEILLG 176 H ++HRDLKP+N+L+N + I++ DFG A+ + V T Y +PE LL Sbjct: 154 HGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE-LLT 212 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 K + D+W+LGCI ++V F +E + IF+ + + D+ Sbjct: 213 EKSACKSSDLWALGCIIYQLVAGLPPFRAGNE----YLIFQKI----------IKLEYDF 258 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 F AR K++ LD R +M Y P K AHPFF+ VT Sbjct: 259 PEKFFPKARDLVEKLL-VLDATKRLGCEEMEGYGPLK--------AHPFFESVT 303 >3QA8-A nrPDB Length = 676 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 65/202 (32%), Positives = 103/202 (50%), Gaps = 14/202 (6%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 E++G G +G V + ++ TGE VA+K+ R + + + EI ++K+LNHPN+V Sbjct: 20 ERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCL-EIQIMKKLNHPNVVSAR 78 Query: 68 DVIHTENKL------YLVFEFLHQ-DLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCH 119 +V KL L E+ DL+K+++ G+ I++ L + L + H Sbjct: 79 EVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRYLH 138 Query: 120 SHRVLHRDLKPQNLLIN---TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 +R++HRDLKP+N+++ K+ D G A+ T V TL Y APE LL Sbjct: 139 ENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQG-ELCTEFVGTLQYLAPE-LLE 196 Query: 177 CKYYSTAVDIWSLGCIFAEMVT 198 K Y+ VD WS G + E +T Sbjct: 197 QKKYTVTVDYWSFGTLAFECIT 218 >4E20-A nrPDB Length = 290 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 66/207 (31%), Positives = 104/207 (50%), Gaps = 19/207 (9%) Query: 4 FQKVEKIGEGTYGVV----YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 +K+ +GEG +G V Y N TGE+VA+K ++ + + S REI +L+ L Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQ-LRSGWQREIEILRTLY 68 Query: 60 HPNIVKLLDVI--HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 H +IVK E + LV E++ L D + L + + Q+ +G+A+ Sbjct: 69 HEHIVKYKGCCEDQGEKSVQLVMEYV--PLGSLRDYLPRHCVGLAQLLLFAQQICEGMAY 126 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV------TLWYRAP 171 H+ +HR L +N+L++ + +K+ DFGLA+A VP + V WY AP Sbjct: 127 LHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKA--VPEGHEYYRVREDGDSPVFWY-AP 183 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVT 198 E L CK+Y A D+WS G E++T Sbjct: 184 ECLKECKFY-YASDVWSFGVTLYELLT 209 >4GS6-A nrPDB Length = 315 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 76/220 (34%), Positives = 110/220 (50%), Gaps = 30/220 (13%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 E +G G +GVV KA K + VA+K+I ++E + I E+ L +NHPNIVKL Sbjct: 15 EVVGRGAFGVVCKA--KWRAKDVAIKQIESESERKAF----IVELRQLSRVNHPNIVKLY 68 Query: 68 DVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIK-----SYLFQLLQGLAFCHSH 121 N + LV E+ L + + PLP S+ Q QG+A+ HS Sbjct: 69 GA--CLNPVCLVMEYAEGGSLYNVLHGAE----PLPYYTAAHAMSWCLQCSQGVAYLHSM 122 Query: 122 R---VLHRDLKPQNLLINTEGAI-KLADFGLARAFGVPVRTY-THEVVTLWYRAPEILLG 176 + ++HRDLKP NLL+ G + K+ DFG A ++T+ T+ + + APE+ G Sbjct: 123 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTA----CDIQTHMTNNKGSAAWMAPEVFEG 178 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF 216 YS D++S G I E++TRR F D FRI Sbjct: 179 SN-YSEKCDVFSWGIILWEVITRRKPF--DEIGGPAFRIM 215 >6DBM-A nrPDB Length = 318 Score = 88.2 bits (217), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 67/207 (32%), Positives = 103/207 (49%), Gaps = 19/207 (9%) Query: 4 FQKVEKIGEGTYGVV----YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 +K+ +GEG +G V Y N TGE+VA+K ++ D + S +EI +L+ L Sbjct: 33 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHR-SGWKQEIDILRTLY 91 Query: 60 HPNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 H +I+K L LV E++ L D I L + + Q+ +G+A+ Sbjct: 92 HEHIIKYKGCCEDAGAASLQLVMEYV--PLGSLRDYLPRHSIGLAQLLLFAQQICEGMAY 149 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV------TLWYRAP 171 HS +HRDL +N+L++ + +K+ DFGLA+A VP + V WY AP Sbjct: 150 LHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKA--VPEGHEYYRVREDGDSPVFWY-AP 206 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVT 198 E L K+Y A D+WS G E++T Sbjct: 207 ECLKEYKFY-YASDVWSFGVTLYELLT 232 >3GUB-A nrPDB Length = 295 Score = 88.2 bits (217), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 81/292 (27%), Positives = 140/292 (47%), Gaps = 44/292 (15%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVA---LKKIRLDTETEGVPSTAI-REISLLKELNHPNI 63 E++G G + VV K R K TG A +KK R + GV I RE+S+LKE+ HPN+ Sbjct: 17 EELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNV 76 Query: 64 VKLLDVIHTENKLYLVFEFLH-QDLKKFM-DASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 + L +V + + L+ E + +L F+ + +LT +L Q+L G+ + HS Sbjct: 77 ITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTE---EEATEFLKQILNGVYYLHSL 133 Query: 122 RVLHRDLKPQNLLINTEGA----IKLADFGLARA--FGVPVRTYTHEVVTLWYRAPEILL 175 ++ H DLKP+N+++ IK+ DFGLA FG + + T + APEI + Sbjct: 134 QIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFG---NEFKNIFGTPEFVAPEI-V 189 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 + D+WS+G I +++ + F GD++ + L + S + Sbjct: 190 NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANV----------------SAVN 233 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 Y ++ + FS + + ++L DP KR++ + +L HP+ + Sbjct: 234 Y-----EFEDEYFSNTSAL----AKDFIRRLLVKDPKKRMTIQDSLQHPWIK 276 >4NIF-A nrPDB Length = 333 Score = 87.8 bits (216), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 83/287 (28%), Positives = 123/287 (42%), Gaps = 43/287 (14%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 E IG G+Y + +K T A+K I +++ PS I EI LL+ HPNI+ L Sbjct: 14 ETIGVGSYSECKRCVHKATNMEYAVKVI---DKSKRDPSEEI-EI-LLRYGQHPNIITLK 68 Query: 68 DVIHTENKLYLVFEFLHQD--LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 125 DV +YLV E + L K + + + L + + + + HS V+H Sbjct: 69 DVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFV---LHTIGKTVEYLHSQGVVH 125 Query: 126 RDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 RDLKP N+L E +++ DFG A+ T + APE+L + Y Sbjct: 126 RDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR-QGYD 184 Query: 182 TAVDIWSLGCIFAEMVTRRALF---PGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 DIWSLG + M+ F P D+ + L RI T W V+ Sbjct: 185 EGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVS------- 237 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 E + L+S+MLH DP++R++AK L HP+ Sbjct: 238 ------------------ETAKDLVSKMLHVDPHQRLTAKQVLQHPW 266 >2I0E-A nrPDB Length = 353 Score = 87.8 bits (216), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 113/218 (51%), Gaps = 27/218 (12%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLKELNHPNIVKLL 67 +G+G++G V + K T E+ A+K ++ D + + V T + + L P + +L Sbjct: 28 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 87 Query: 68 DVIHTENKLYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 T ++LY V E+++ Q + +F + A+ Y ++ GL F Sbjct: 88 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF---------YAAEIAIGLFFLQ 138 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAF---GVPVRTYTHEVVTLWYRAPEILLG 176 S +++RDLK N+++++EG IK+ADFG+ + GV +T+ T Y APEI + Sbjct: 139 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAPEI-IA 194 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR 214 + Y +VD W+ G + EM+ +A F G+ E D+LF+ Sbjct: 195 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQ 231 >3PFQ-A nrPDB Length = 674 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 113/218 (51%), Gaps = 27/218 (12%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLKELNHPNIVKLL 67 +G+G++G V + K T E+ A+K ++ D + + V T + + L P + +L Sbjct: 349 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 408 Query: 68 DVIHTENKLYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 T ++LY V E+++ Q + +F + A+ Y ++ GL F Sbjct: 409 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVF---------YAAEIAIGLFFLQ 459 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAF---GVPVRTYTHEVVTLWYRAPEILLG 176 S +++RDLK N+++++EG IK+ADFG+ + GV +T+ T Y APEI + Sbjct: 460 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAPEI-IA 515 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR 214 + Y +VD W+ G + EM+ +A F G+ E D+LF+ Sbjct: 516 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQ 552 >1AD5-A nrPDB Length = 438 Score = 87.4 bits (215), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 71/254 (27%), Positives = 127/254 (50%), Gaps = 34/254 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKAR-NKLTGEVVALKKIRLDTETEGVPSTA--IREISLLKEL 58 E+ + +K+G G +G V+ A NK T K+ + T G S + E +++K L Sbjct: 182 ESLKLEKKLGAGQFGEVWMATYNKHT-------KVAVKTMKPGSMSVEAFLAEANVMKTL 234 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 H +VKL V+ T+ +Y++ EF+ + L F+ + + PLP + + Q+ +G+AF Sbjct: 235 QHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAF 293 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG-VPVRTYTHEVVTLWYRAPEILLG 176 +HRDL+ N+L++ K+ADFGLAR P++ + APE + Sbjct: 294 IEQRNYIHRDLRAANILVSASLVCKIADFGLARVGAKFPIK----------WTAPEA-IN 342 Query: 177 CKYYSTAVDIWSLGCIFAEMVTR-RALFPGDSE------IDQLFRIFRTLGTPDE---VV 226 ++ D+WS G + E+VT R +PG S +++ +R+ R P+E ++ Sbjct: 343 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIM 402 Query: 227 WPGVTSMPDYKPSF 240 + P+ +P+F Sbjct: 403 MRCWKNRPEERPTF 416 >3DB8-A nrPDB Length = 317 Score = 87.4 bits (215), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 82/301 (27%), Positives = 135/301 (44%), Gaps = 46/301 (15%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEV----VALKKIRLDTETEGVPSTAIREISLLK 56 M+ + + +G+G + Y+ + T EV V K + L + ST EI++ K Sbjct: 41 MKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMST---EIAIHK 97 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFLHQ----DLKKFMDASALTGIPLPLIKSYLFQLL 112 L++P++V ++ +Y+V E + +L K A + P + ++ Q + Sbjct: 98 SLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKA-----VTEPEARYFMRQTI 152 Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 QG+ + H++RV+HRDLK NL +N + +K+ DFGLA T Y APE Sbjct: 153 QGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPE 212 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 +L K +S VDIWSLGCI ++ +G P P TS Sbjct: 213 VLCK-KGHSFEVDIWSLGCILYTLL---------------------VGKP-----PFETS 245 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 K ++ + + ++S V ++ +L+ +MLH DP R S L FF P Sbjct: 246 C--LKETYIRIKKNEYS-VPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAP 302 Query: 293 V 293 + Sbjct: 303 M 303 >6CTH-A nrPDB Length = 309 Score = 87.0 bits (214), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 72/225 (32%), Positives = 113/225 (50%), Gaps = 22/225 (9%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 NF K+GEG +G VY+ + + +A+KK+ ++ +G+ A E+ ++ L H N Sbjct: 16 NFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASK-QGIKEYA-SEVKIISRLRHKN 73 Query: 63 IVKLLDVIHTENKLYLVFEFLHQ---DLKKFMDASALT-GIPLPLIKSYLFQLLQGLAFC 118 +VKL+ H +L LV+EF+ D F S LT + ++K L L + Sbjct: 74 LVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVK----DLASALLYL 129 Query: 119 HS---HRVLHRDLKPQNLLINTEGAIKLADFGLAR----AFGVPVRTYTHEVVTLWYRAP 171 H H VLHRD+K N+++++ KL DFGLAR A G+ T T+ Y AP Sbjct: 130 HEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGL---KKTLLAGTVGYMAP 186 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRI 215 E L K S D++S G + E+ + RR++ P E + L + Sbjct: 187 ECLSSGK-ASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLV 230 >3ORP-A nrPDB Length = 311 Score = 87.0 bits (214), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 70/245 (28%), Positives = 113/245 (46%), Gaps = 22/245 (8%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKEL 58 + ++ E +G G V+ AR+ VA+K +R D + PS +R E L Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARD--PSFYLRFRREAQNAAAL 69 Query: 59 NHPNIVKLLDVIHTENKL----YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL-- 112 NHP IV + D E Y+V E++ D D G P+ +++ Sbjct: 70 NHPAIVAVYDTGEAETPAGPLPYIVMEYV--DGVTLRDIVHTEG---PMTPKRAIEVIAD 124 Query: 113 --QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF---GVPVRTYTHEVVTLW 167 Q L F H + ++HRD+KP N++I+ A+K+ DFG+ARA G V + T Sbjct: 125 ACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQ 184 Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227 Y +PE G + + D++SLGC+ E++T F GDS + ++ R P Sbjct: 185 YLSPEQARGDSVDARS-DVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARH 243 Query: 228 PGVTS 232 G+++ Sbjct: 244 EGLSA 248 >2HK5-A nrPDB Length = 270 Score = 87.0 bits (214), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 72/256 (28%), Positives = 128/256 (50%), Gaps = 28/256 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKAR-NKLTGEVVALKKIRLDTETEGVPSTA--IREISLLKEL 58 E+ + +K+G G +G V+ A NK T K+ + T G S + E +++K L Sbjct: 15 ESLKLEKKLGAGQFGEVWMATYNKHT-------KVAVKTMKPGSMSVEAFLAEANVMKTL 67 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 H +VKL V+ T+ +Y++ EF+ + L F+ + + PLP + + Q+ +G+AF Sbjct: 68 QHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAF 126 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE---VVTLWYRAPEIL 174 +HRDL+ N+L++ K+ADFGLAR + YT + + APE Sbjct: 127 IEQRNYIHRDLRAANILVSASLVCKIADFGLARV--IEDNEYTAREGAKFPIKWTAPEA- 183 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTR-RALFPGDSE------IDQLFRIFRTLGTPDE--- 224 + ++ D+WS G + E+VT R +PG S +++ +R+ R P+E Sbjct: 184 INFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYN 243 Query: 225 VVWPGVTSMPDYKPSF 240 ++ + P+ +P+F Sbjct: 244 IMMRCWKNRPEERPTF 259 >3ALO-A nrPDB Length = 327 Score = 87.0 bits (214), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 74/293 (25%), Positives = 129/293 (44%), Gaps = 33/293 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E+ + + +IG G YG V K +K +G+++A+K+IR + + + +++ + P Sbjct: 22 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 81 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDA--SALTG-IPLPLIKSYLFQLLQGLAFC 118 IV+ + E ++ E + KF S L IP ++ ++ L Sbjct: 82 YIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHL 141 Query: 119 HSH-RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL--- 174 + +++HRD+KP N+L++ G IKL DFG++ V T + Y APE + Sbjct: 142 KENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQL-VDSIAKTRDAGCRPYMAPERIDPS 200 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPG-DSEIDQLFRIFRTLGTPDEVVWPGVTSM 233 + Y D+WSLG E+ T R +P +S DQL ++ + G P ++ + Sbjct: 201 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK--GDPPQL---SNSEE 255 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 ++ PSF + +K D +KR K L HPF Sbjct: 256 REFSPSFINFVNLCLTK-------------------DESKRPKYKELLKHPFI 289 >3HMP-A nrPDB Length = 342 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 80/304 (26%), Positives = 128/304 (42%), Gaps = 44/304 (14%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH--PNIV 64 +++IG G V++ N+ ++ A+K + L+ + EI+ L +L I+ Sbjct: 61 LKQIGSGGSSKVFQVLNE-KKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKII 119 Query: 65 KLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 +L D T+ +Y+V E + DL ++ I KSY +L+ + H H ++ Sbjct: 120 RLYDYEITDQYIYMVMECGNIDLNSWLKKKK--SIDPWERKSYWKNMLEAVHTIHQHGIV 177 Query: 125 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT--HEVVTLWYRAPEILLGCK---- 178 H DLKP N LI +G +KL DFG+A + +V T+ Y PE + Sbjct: 178 HSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRE 236 Query: 179 ------YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 S D+WSLGCI M + P I+Q+ ++ + Sbjct: 237 NGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQISKLHAIID------------ 282 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 P+++ FP +D V L L DP +RIS LAHP+ Q T P Sbjct: 283 -PNHEIEFPDIPEKDLQDV-----------LKCCLKRDPKQRISIPELLAHPYVQIQTHP 330 Query: 293 VPHL 296 V + Sbjct: 331 VNQM 334 >5AP3-A nrPDB Length = 313 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 80/304 (26%), Positives = 128/304 (42%), Gaps = 44/304 (14%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH--PNIV 64 +++IG G V++ N+ ++ A+K + L+ + EI+ L +L I+ Sbjct: 33 LKQIGSGGSSKVFQVLNE-KKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKII 91 Query: 65 KLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 +L D T+ +Y+V E + DL ++ I KSY +L+ + H H ++ Sbjct: 92 RLYDYEITDQYIYMVMECGNIDLNGWLKKKK--SIDPWERKSYWKNMLEAVHTIHQHGIV 149 Query: 125 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT--HEVVTLWYRAPEILLGCK---- 178 H DLKP N LI +G +KL DFG+A + +V T+ Y PE + Sbjct: 150 HSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRE 208 Query: 179 ------YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 S D+WSLGCI M + P I+Q+ ++ + Sbjct: 209 NGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQISKLHAIID------------ 254 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 P+++ FP +D V L L DP +RIS LAHP+ Q T P Sbjct: 255 -PNHEIEFPDIPEKDLQDV-----------LKCCLKRDPKQRISIPELLAHPYVQIQTHP 302 Query: 293 VPHL 296 V + Sbjct: 303 VNQM 306 >6GVJ-A nrPDB Length = 429 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 78/304 (25%), Positives = 129/304 (42%), Gaps = 44/304 (14%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH--PNIV 64 +++IG G V++ N+ ++ A+K + L+ + EI+ L +L I+ Sbjct: 149 LKQIGSGGSSKVFQVLNE-KKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKII 207 Query: 65 KLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 +L D T+ +Y+V E + DL ++ I KSY +L+ + H H ++ Sbjct: 208 RLYDYEITDQYIYMVMECGNIDLNSWLKKKK--SIDPWERKSYWKNMLEAVHTIHQHGIV 265 Query: 125 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT--HEVVTLWYRAPEILLGCK---- 178 H DLKP N LI +G +KL DFG+A + +V T+ Y PE + Sbjct: 266 HSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRE 324 Query: 179 ------YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 S D+WSLGCI M + P I+Q+ ++ + E+ +P + Sbjct: 325 NGKSKSKISPKSDVWSLGCILYYMTYGKT--PFQQIINQISKLHAIIDPNHEIEFPDIP- 381 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 ++D + +L L DP +RIS LAHP+ Q T P Sbjct: 382 -----------------------EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHP 418 Query: 293 VPHL 296 V + Sbjct: 419 VNQM 422 >5H2U-A nrPDB Length = 267 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 63/217 (29%), Positives = 106/217 (48%), Gaps = 8/217 (3%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E F K+G G +G V++ K +V A+K I D EI +K+L H Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKDRVQV-AIKVISRDNLLH--QQMLQSEIQAMKKLRHK 62 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +I+ L V+ + +Y++ E + + L + + S +P+ + +Q+ +G+ + S Sbjct: 63 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 122 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR-TYTHEVVTLWYRAPEILLGCKY 179 +HRDL +N+L+ K+ DFGLAR V ++ H + W APE L + Sbjct: 123 QNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKW-TAPEA-LSRGH 180 Query: 180 YSTAVDIWSLGCIFAEMVTRRAL-FPGDSEIDQLFRI 215 YST D+WS G + EM +R + +PG S + R+ Sbjct: 181 YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRV 217 >4KIK-B nrPDB Length = 677 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 64/202 (31%), Positives = 100/202 (49%), Gaps = 14/202 (6%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 E++G G +G V + N+ TGE +A+K+ R + + EI +++ L HPN+V Sbjct: 25 ERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL-EIQIMRRLTHPNVVAAR 83 Query: 68 DVIHTENKL------YLVFEFLHQ-DLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCH 119 DV L L E+ DL+K+++ G+ I + L + L + H Sbjct: 84 DVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLH 143 Query: 120 SHRVLHRDLKPQNLLINT-EGAI--KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 +R++HRDLKP+N+++ E + K+ D G A+ T V TL Y APE+L Sbjct: 144 ENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQG-SLCTSFVGTLQYLAPELLEQ 202 Query: 177 CKYYSTAVDIWSLGCIFAEMVT 198 KY T VD WS G + E +T Sbjct: 203 QKYTVT-VDYWSFGTLAFECIT 223 >5UIU-A nrPDB Length = 323 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 69/200 (34%), Positives = 103/200 (51%), Gaps = 18/200 (9%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIR--LDTETEGVPSTAIREISLLKELNHPNIVKL 66 K+GEG +GVVYK + VA+KK+ +D TE + +EI ++ + H N+V+L Sbjct: 54 KMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDA-SALTGIPLPLIKSYLFQLLQGLA----FCHSH 121 L + L LV+ ++ +D S L G P PL ++ QG A F H + Sbjct: 112 LGFSSDGDDLCLVYVYMPN--GSLLDRLSCLDGTP-PLSWHMRCKIAQGAANGINFLHEN 168 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARA---FGVPVRTYTHEVVTLWYRAPEILLGCK 178 +HRD+K N+L++ K++DFGLARA F V T + V T Y APE L G Sbjct: 169 HHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMT-SRIVGTTAYMAPEALRG-- 225 Query: 179 YYSTAVDIWSLGCIFAEMVT 198 + DI+S G + E++T Sbjct: 226 EITPKSDIYSFGVVLLEIIT 245 >6NPU-A nrPDB Length = 298 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 65/227 (28%), Positives = 114/227 (50%), Gaps = 15/227 (6%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKELNHPNIVKLL 67 K+G G YG VY+ K VA+K ++ DT E E ++E +++KE+ HPN+V+LL Sbjct: 33 KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF----LKEAAVMKEIKHPNLVQLL 88 Query: 68 DVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 V E Y++ EF+ + +L ++ + ++ Q+ + + +HR Sbjct: 89 GVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHR 148 Query: 127 DLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVD 185 DL +N L+ +K+ADFGL+R G + + + APE L K +S D Sbjct: 149 DLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK-FSIKSD 207 Query: 186 IWSLGCIFAEMVTR-RALFPGD--SEIDQL----FRIFRTLGTPDEV 225 +W+ G + E+ T + +PG S++ +L +R+ R G P++V Sbjct: 208 VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 254 >4B6L-A nrPDB Length = 281 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 74/291 (25%), Positives = 118/291 (40%), Gaps = 32/291 (10%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELNHP 61 + K +G+G + Y+A + TG A+K I + I EI L ++L H Sbjct: 10 TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR 69 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +IV+ + +Y+ E + + + T + P ++ YL Q+L GL + H Sbjct: 70 HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLE-PEVRYYLRQILSGLKYLHQR 128 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 +LHRDLK N I +K+ DFGLA P + T Y APE+LL + + Sbjct: 129 GILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLR-QGHG 187 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 D+WSLGC+ ++ F +++ + +R + + P S+P Sbjct: 188 PEADVWSLGCVMYTLLCGSPPFE-TADLKETYRCIKQV----HYTLPASLSLP------- 235 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 R LL+ +L P R S L H FF P Sbjct: 236 -----------------ARQLLAAILRASPRDRPSIDQILRHDFFTKGYTP 269 >4XEY-B nrPDB Length = 408 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 65/227 (28%), Positives = 114/227 (50%), Gaps = 15/227 (6%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKELNHPNIVKLL 67 K+G G YG VY+ K VA+K ++ DT E E ++E +++KE+ HPN+V+LL Sbjct: 132 KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF----LKEAAVMKEIKHPNLVQLL 187 Query: 68 DVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 V E Y++ EF+ + +L ++ + ++ Q+ + + +HR Sbjct: 188 GVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHR 247 Query: 127 DLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVD 185 DL +N L+ +K+ADFGL+R G + + + APE L K +S D Sbjct: 248 DLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK-FSIKSD 306 Query: 186 IWSLGCIFAEMVTR-RALFPGD--SEIDQL----FRIFRTLGTPDEV 225 +W+ G + E+ T + +PG S++ +L +R+ R G P++V Sbjct: 307 VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 353 >1VZO-A nrPDB Length = 355 Score = 85.5 bits (210), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 77/303 (25%), Positives = 138/303 (45%), Gaps = 39/303 (12%) Query: 1 MENFQKVEKIGEGTYGVVY---KARNKLTGEVVALKKIRLDTETEGVPST--AIREISLL 55 +ENF+ ++ +G G YG V+ K TG++ A+K ++ T + +T E +L Sbjct: 53 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 112 Query: 56 KELNH-PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 + + P +V L TE KL+L+ ++++ + F S ++ Y+ +++ Sbjct: 113 EHIRQSPFLVTLHYAFQTETKLHLILDYINGG-ELFTHLSQRERFTEHEVQIYVGEIVLA 171 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEI 173 L H +++RD+K +N+L+++ G + L DFGL++ F ++ T+ Y AP+I Sbjct: 172 LEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDI 231 Query: 174 LLGCKY-YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 + G + AVD WSLG + E++T + F D E + I R + + S Sbjct: 232 VRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRI----------LKS 281 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFFQ 287 P Y A + L+ ++L DP KR+ A H FFQ Sbjct: 282 EPPYPQEMSALA---------------KDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQ 326 Query: 288 DVT 290 + Sbjct: 327 KIN 329 >4U41-A nrPDB Length = 332 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 67/210 (31%), Positives = 101/210 (48%), Gaps = 23/210 (10%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH-PN 62 F+ VE +G GTYG VYK R+ TG++ A+K + + TE EI++LK+ +H N Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV---TEDEEEEIKLEINMLKKYSHHRN 82 Query: 63 IVKLLDVI------HTENKLYLVFEFLHQ----DLKKFMDASALTGIPLPLIKSYLFQLL 112 I +++L+LV EF DL K + L + I ++L Sbjct: 83 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISR---EIL 139 Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 +GLA H H V+HRD+K QN+L+ +KL DFG++ V + T ++ APE Sbjct: 140 RGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 199 Query: 173 ILLGCK-----YYSTAVDIWSLGCIFAEMV 197 + + C Y D+WS G EM Sbjct: 200 V-IACDENPDATYDYRSDLWSCGITAIEMA 228 >4E93-A nrPDB Length = 377 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 55/194 (28%), Positives = 98/194 (50%), Gaps = 6/194 (3%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 E+IG G +G V+ R + +VA+K R +T + + ++E +LK+ +HPNIV+L+ Sbjct: 120 EQIGRGNFGEVFSGRLRADNTLVAVKSCR-ETLPPDLKAKFLQEARILKQYSHPNIVRLI 178 Query: 68 DVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 V + +Y+V E + D F+ + + + + G+ + S +HR Sbjct: 179 GVCTQKQPIYIVMELVQGGDFLTFLRTEGAR-LRVKTLLQMVGDAAAGMEYLESKCCIHR 237 Query: 127 DLKPQNLLINTEGAIKLADFGLAR--AFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAV 184 DL +N L+ + +K++DFG++R A GV + V + + APE L YS+ Sbjct: 238 DLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEA-LNYGRYSSES 296 Query: 185 DIWSLGCIFAEMVT 198 D+WS G + E + Sbjct: 297 DVWSFGILLWETFS 310 >4PL5-B nrPDB Length = 435 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 84/294 (28%), Positives = 128/294 (43%), Gaps = 45/294 (15%) Query: 10 IGEGTYG-VVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVKLL 67 +G G G +VYK VA+K+I + S A RE+ LL+E + HPN+++ Sbjct: 35 LGHGAEGTIVYKG--MFDNRDVAVKRILPE-----CFSFADREVQLLRESDEHPNVIRYF 87 Query: 68 DVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 Y+ E L+++++ + L I + L Q GLA HS ++HRD Sbjct: 88 CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPI-TLLHQTTSGLAHLHSLNIVHRD 146 Query: 128 LKPQNLLI---NTEGAIK--LADFGLARAFGVPVRTYTHEV---VTLWYRAPEILL-GCK 178 LKP N+L+ N G IK ++DFGL + V +++ T + APE+L CK Sbjct: 147 LKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCK 206 Query: 179 YYST-AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 T VDI+S GC+F +++ P + + I D Sbjct: 207 DNPTYTVDIFSAGCVFYYVIS-EGYHPFGKSLQRQANILLGACNLD-------------- 251 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 F +D R L+ +M+ DP +R SAK L HPFF + K Sbjct: 252 -CFHSDKHEDVI---------ARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEK 295 >5TOS-A nrPDB Length = 395 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 70/217 (32%), Positives = 112/217 (51%), Gaps = 20/217 (9%) Query: 3 NFQKVEKIGEGTYGVVYKA---------RNKLTGEVVALKKIRLDTETEGVPSTAIREIS 53 NF+ IGEG +G V+K TG V+A+KK L+ E + EI+ Sbjct: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKK--LNQEGFQGHREWLTEIN 123 Query: 54 LLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLP--LIKSYLFQ 110 L +L+HPN+VKL+ + LV+EF+ + L+ + PLP L + Sbjct: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 Query: 111 LLQGLAFCHSH--RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY--THEVVTL 166 +GLAF HS +V++RD+K N+L++ + KL+DFGLAR + +Y T + T Sbjct: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 Query: 167 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL 202 Y APE + + + D++S G + E+++ +RAL Sbjct: 244 GYAAPEY-MSSGHLNARSDVYSFGVLLLEILSGKRAL 279 >2YAB-A nrPDB Length = 361 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 80/296 (27%), Positives = 143/296 (48%), Gaps = 41/296 (13%) Query: 1 MENFQKV-EKIGEGTYGVVYKARNKLTG-EVVA--LKKIRLDTETEGVPSTAI-REISLL 55 +E+F + E++G G + +V K R K TG E A +KK + GV I RE+S+L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSIL 69 Query: 56 KELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQG 114 +++ HPNI+ L DV + L+ E + +L F+ + + S++ Q+L G Sbjct: 70 RQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFL--AQKESLSEEEATSFIKQILDG 127 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 + + H+ ++ H DLKP+N+++ + IKL DFGLA V + + T + A Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVA 186 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 PEI + + D+WS+G I +++ + F GD++ + L + Sbjct: 187 PEI-VNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETL---------------ANI 230 Query: 231 TSMP-DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 T++ D+ F FS+ E + + ++L + KR++ + AL HP+ Sbjct: 231 TAVSYDFDEEF-------FSQT----SELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >4XCU-A nrPDB Length = 300 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 114/226 (50%), Gaps = 22/226 (9%) Query: 10 IGEGTYGVVYKAR-------NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HP 61 +GEG +G V +A VA+K ++ D ++ + + E+ ++K + H Sbjct: 25 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK-DNASDKDLADLVSEMEVMKLIGRHK 83 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTG-----IPLPLIKSYLFQLLQGL 115 NI+ LL V E LY++ E + +L++F+ A G + P++ S +Q+ +G+ Sbjct: 84 NIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQVARGM 143 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARA---FGVPVRTYTHEVVTLWYRAPE 172 + S + +HRDL +N+L+ + +K+ADFGLAR +T + W APE Sbjct: 144 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWM-APE 202 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFR 217 L + Y+ D+WS G + E+ T + +PG +++LF + R Sbjct: 203 ALFD-RVYTHQSDVWSFGILLWEIFTLGGSPYPG-IPVEELFSLLR 246 >2DQ7-X nrPDB Length = 283 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 115/227 (50%), Gaps = 15/227 (6%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEV-VALKKIRLDTETEGVPSTAIREISLLKELNH 60 E+ Q ++++G G +G V+ G VA+K ++ T + P + + E ++K+L H Sbjct: 9 ESLQLIKRLGNGQFGEVWMG--TWNGNTKVAIKTLKPGTMS---PESFLEEAQIMKKLKH 63 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 +V+L V+ +E +Y+V E++++ L F+ + LP + Q+ G+A+ Sbjct: 64 DKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIE 122 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT---LWYRAPEILLG 176 +HRDL+ N+L+ K+ADFGLAR + YT + + APE L Sbjct: 123 RMNYIHRDLRSANILVGNGLICKIADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALY 180 Query: 177 CKYYSTAVDIWSLGCIFAEMVTR-RALFPGDSEIDQLFRIFRTLGTP 222 + ++ D+WS G + E+VT+ R +PG + + L ++ R P Sbjct: 181 GR-FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMP 226 >6E9W-A nrPDB Length = 443 Score = 84.7 bits (208), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 69/233 (29%), Positives = 109/233 (46%), Gaps = 14/233 (6%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNH 60 E+++ V+ IG G +G V R+K T +V A+K + + + + E ++ N Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 161 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 P +V+L + LY+V E++ DL M + +P + Y +++ L H Sbjct: 162 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLM---SNYDVPEKWARFYTAEVVLALDAIH 218 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYTHEVVTLWYRAPEILL-- 175 S +HRD+KP N+L++ G +KLADFG VR T V T Y +PE+L Sbjct: 219 SMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDT-AVGTPDYISPEVLKSQ 277 Query: 176 -GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF---RTLGTPDE 224 G YY D WS+G EM+ F DS + +I +L PD+ Sbjct: 278 GGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDD 330 >4C0T-A nrPDB Length = 974 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 66/229 (28%), Positives = 109/229 (47%), Gaps = 37/229 (16%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI--RLDTETEGVPSTAIREISLLKELNH 60 +F+ +++GEG+Y V A +K+TG+ A+K + R + + V I + +L + N Sbjct: 267 DFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNR 326 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF----------- 109 ++ L ++ LY V ++ A G L LIK Y Sbjct: 327 LGVISLYFTFQDKDSLYFVLDY------------ASNGELLTLIKRYNTLNEECTRHFGA 374 Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLAR----------AFGVPVRTY 159 Q+L + + H + V+HRDLKP+N+L++ + I++ DFG AR + V VR Sbjct: 375 QILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAK 434 Query: 160 THEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSE 208 + V T Y +PE LL KY D+W+ GCI +M+ + F +E Sbjct: 435 SF-VGTAEYVSPE-LLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNE 481 >3MV5-A nrPDB Length = 342 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 80/300 (26%), Positives = 137/300 (45%), Gaps = 46/300 (15%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLKEL 58 M F+ ++ +G+GT+G V + K TG A+K ++ + + V T + E +L+ Sbjct: 9 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTENRVLQNS 67 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HP + L T ++L V E+ + + F S + Y +++ L + Sbjct: 68 RHPFLTALKYSFQTHDRLCFVMEYANGG-ELFFHLSRERVFSEDRARFYGAEIVSALDYL 126 Query: 119 HSHR-VLHRDLKPQNLLINTEGAIKLADFGLARAF---GVPVRTYTHEVVTLWYRAPEIL 174 HS + V++RDLK +NL+++ +G IK+ DFGL + G ++T+ T Y APE+L Sbjct: 127 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPEVL 183 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 Y AVD W LG + EM+ R F + + ++LF + +E+ +P Sbjct: 184 EDND-YGRAVDWWGLGVVMYEMMCGRLPFY-NQDHEKLFELILM----EEIRFPRT---- 233 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFFQDV 289 L + +SLLS +L DP +R+ AK + H FF + Sbjct: 234 --------------------LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 273 >4UYA-A nrPDB Length = 340 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 66/217 (30%), Positives = 100/217 (46%), Gaps = 20/217 (9%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS--TAIREISLLKELN 59 E + E IG G +G VY+A G+ VA+K R D E + + + RE L L Sbjct: 26 ERLELKELIGAGGFGQVYRA--TWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLR 83 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 HPNI++L V + L LV EF A A IP ++ ++ Q+ +G+ + H Sbjct: 84 HPNIIELRGVCLQQPHLCLVLEFARGG--ALNRALAGRRIPPHVLVNWAVQIARGMLYLH 141 Query: 120 SHR---VLHRDLKPQNLLI--------NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWY 168 +LHRDLK N+L+ +K+ DFGLAR + + T + Sbjct: 142 EEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYA--W 199 Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPG 205 APE+ + +S DIWS G + E++T + G Sbjct: 200 MAPEV-IKSSLFSKGSDIWSYGVLLWELLTGEVPYRG 235 >5KCV-A nrPDB Length = 460 Score = 84.0 bits (206), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 80/300 (26%), Positives = 137/300 (45%), Gaps = 46/300 (15%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLKEL 58 M F+ ++ +G+GT+G V + K TG A+K ++ + + V T + E +L+ Sbjct: 161 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTENRVLQNS 219 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HP + L T ++L V E+ + + F S + Y +++ L + Sbjct: 220 RHPFLTALKYSFQTHDRLCFVMEYANGG-ELFFHLSRERVFSEDRARFYGAEIVSALDYL 278 Query: 119 HSHR-VLHRDLKPQNLLINTEGAIKLADFGLARAF---GVPVRTYTHEVVTLWYRAPEIL 174 HS + V++RDLK +NL+++ +G IK+ DFGL + G ++T+ T Y APE+L Sbjct: 279 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPEVL 335 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 Y AVD W LG + EM+ R F + + ++LF + +E+ +P Sbjct: 336 EDND-YGRAVDWWGLGVVMYEMMCGRLPFY-NQDHEKLFELILM----EEIRFPRT---- 385 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFFQDV 289 L + +SLLS +L DP +R+ AK + H FF + Sbjct: 386 --------------------LGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 425 >2ZMD-A nrPDB Length = 390 Score = 84.0 bits (206), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 79/304 (25%), Positives = 127/304 (41%), Gaps = 44/304 (14%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH--PNIV 64 +++IG G V++ N+ ++ A+K + L+ + EI+ L +L I+ Sbjct: 61 LKQIGSGGSSKVFQVLNE-KKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKII 119 Query: 65 KLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 +L D T+ +Y+V E + DL ++ I KSY +L+ + H H ++ Sbjct: 120 RLYDYEITDQYIYMVMECGNIDLNSWLKKKK--SIDPWERKSYWKNMLEAVHTIHQHGIV 177 Query: 125 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT--HEVVTLWYRAPEILLGCK---- 178 H DLKP N LI +G +KL DFG+A + +V + Y PE + Sbjct: 178 HSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRE 236 Query: 179 ------YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 S D+WSLGCI M + F I+Q+ ++ + Sbjct: 237 NGKSKSKISPKSDVWSLGCILYYMTYGKTPF--QQIINQISKLHAIID------------ 282 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 P+++ FP +D V L L DP +RIS LAHP+ Q T P Sbjct: 283 -PNHEIEFPDIPEKDLQDV-----------LKCCLKRDPKQRISIPELLAHPYVQIQTHP 330 Query: 293 VPHL 296 V + Sbjct: 331 VNQM 334 >2FO0-A nrPDB Length = 495 Score = 84.0 bits (206), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 64/227 (28%), Positives = 114/227 (50%), Gaps = 15/227 (6%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKELNHPNIVKLL 67 K+G G YG VY+ K VA+K ++ DT E E ++E +++KE+ HPN+V+LL Sbjct: 224 KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF----LKEAAVMKEIKHPNLVQLL 279 Query: 68 DVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 V E Y++ EF+ + +L ++ + ++ Q+ + + +HR Sbjct: 280 GVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHR 339 Query: 127 DLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVD 185 +L +N L+ +K+ADFGL+R G + + + APE L K +S D Sbjct: 340 NLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK-FSIKSD 398 Query: 186 IWSLGCIFAEMVT-RRALFPGD--SEIDQL----FRIFRTLGTPDEV 225 +W+ G + E+ T + +PG S++ +L +R+ R G P++V Sbjct: 399 VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 445 >4YHJ-A nrPDB Length = 584 Score = 84.0 bits (206), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 77/296 (26%), Positives = 131/296 (44%), Gaps = 38/296 (12%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGV-PSTAIREISLLKELNHPN 62 F+ +G+G +G V + + TG++ A KK++ + + A+ E +L+++ Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRF 246 Query: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +V L T++ L LV ++ DLK + G Y +L GL Sbjct: 247 VVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRE 306 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKY 179 R+++RDLKP+N+L++ G I+++D GLA G VR V T+ Y APE++ K Sbjct: 307 RIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRG---RVGTVGYMAPEVVNNEK- 362 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 Y+ + D W LGC+ EM+ + F E +V W V Sbjct: 363 YTFSPDWWGLGCLIYEMIQGHSPFKKYKE---------------KVKWEEVDQR------ 401 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA-----HPFFQDVT 290 + D + ED +S+ +L +P+KR+ + A HP F+D+ Sbjct: 402 ----IKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDIN 453 >4I6B-A nrPDB Length = 308 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 67/259 (25%), Positives = 121/259 (46%), Gaps = 17/259 (6%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELNH 60 + + + + +G+G + Y+ + +V A K I ++ I +EI L + L+H Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHH 87 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 ++V+ + +Y++ E+ + + + A + + P ++ YL Q++ GL + H Sbjct: 88 KHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKV--LTEPEVRYYLRQIVSGLKYLH 145 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGCK 178 +LHRDLK N IN +K+ DFGLA A P+ + T Y +PE+ L + Sbjct: 146 EQEILHRDLKLGNFFINESMELKVGDFGLA-ARLEPLEHRRRTICGTPNYLSPEV-LNKQ 203 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRT--LGTPDEVVWPG---VTSM 233 + DIW+LGC+ M+ R F + + + +R R P ++ P + SM Sbjct: 204 GHGAESDIWALGCVMYTMLLGRPPFE-TTNLKETYRSIREARYTMPSSLLAPAKHLIASM 262 Query: 234 ----PDYKPSFPKWARQDF 248 P+ +PS R DF Sbjct: 263 LSKNPEDRPSLDDIIRHDF 281 >3PLS-A nrPDB Length = 298 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 61/204 (29%), Positives = 108/204 (52%), Gaps = 18/204 (8%) Query: 10 IGEGTYGVVY------KARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 IG+G +GVVY +A+N++ + +L +I TE + V +RE L++ LNHPN+ Sbjct: 29 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRI---TEMQQV-EAFLREGLLMRGLNHPNV 84 Query: 64 VKLLDVIHTENKL--YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 + L+ ++ L L+ H DL +F+ + LI S+ Q+ +G+ + Sbjct: 85 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLI-SFGLQVARGMEYLAEQ 143 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILLGC 177 + +HRDL +N +++ +K+ADFGLAR V+ + H + + + A E L Sbjct: 144 KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTY 203 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRA 201 + ++T D+WS G + E++TR A Sbjct: 204 R-FTTKSDVWSFGVLLWELLTRGA 226 >3DLS-A nrPDB Length = 335 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 98/205 (47%), Gaps = 13/205 (6%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGV------PSTAIREISLL 55 + + + +G G +G V+ A +K + V +K I+ + E EI++L Sbjct: 24 QKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAIL 83 Query: 56 KELNHPNIVKLLDVIHTENKLYLVFEFLHQ--DLKKFMDASALTGIPLPLIKSYLF-QLL 112 + H NI+K+LD+ + LV E DL F+D PL SY+F QL+ Sbjct: 84 SRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPL---ASYIFRQLV 140 Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 + + ++HRD+K +N++I + IKL DFG A YT T+ Y APE Sbjct: 141 SAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTF-CGTIEYCAPE 199 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMV 197 +L+G Y +++WSLG +V Sbjct: 200 VLMGNPYRGPELEMWSLGVTLYTLV 224 >2H8H-A nrPDB Length = 535 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 64/223 (28%), Positives = 113/223 (50%), Gaps = 16/223 (7%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 K+G+G +G V+ T V A+K ++ T + P ++E ++K+L H +V+L Sbjct: 274 KLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 329 Query: 69 VIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 V+ +E +Y+V E++ + L F+ + LP + Q+ G+A+ +HRD Sbjct: 330 VV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 388 Query: 128 LKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT---LWYRAPEILLGCKYYSTAV 184 L+ N+L+ K+ADFGLAR + YT + + APE L + ++ Sbjct: 389 LRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR-FTIKS 445 Query: 185 DIWSLGCIFAEMVTR-RALFPG--DSEI-DQLFRIFRTLGTPD 223 D+WS G + E+ T+ R +PG + E+ DQ+ R +R P+ Sbjct: 446 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE 488 >6F3F-A nrPDB Length = 455 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 64/223 (28%), Positives = 114/223 (51%), Gaps = 16/223 (7%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 K+G+G +G V+ T V A+K ++ T + P ++E ++K+L H +V+L Sbjct: 194 KLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 249 Query: 69 VIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 V+ +E +Y+V E++++ L F+ + LP + Q+ G+A+ +HRD Sbjct: 250 VV-SEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRD 308 Query: 128 LKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT---LWYRAPEILLGCKYYSTAV 184 L+ N+L+ K+ADFGLAR + YT + + APE L + ++ Sbjct: 309 LRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR-FTIKS 365 Query: 185 DIWSLGCIFAEMVTR-RALFPG--DSEI-DQLFRIFRTLGTPD 223 D+WS G + E+ T+ R +PG + E+ DQ+ R +R P+ Sbjct: 366 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE 408 >2A1A-B nrPDB Length = 284 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 56/212 (26%), Positives = 108/212 (50%), Gaps = 25/212 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 +F+++E IG G +G V+KA++++ G+ +K+++ + E A RE+ L +L+H N Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEK------AEREVKALAKLDHVN 65 Query: 63 IVKLLDV---------IHTENK-------LYLVFEFLHQD-LKKFMDASALTGIPLPLIK 105 IV ++N L++ EF + L+++++ + L Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLAL 125 Query: 106 SYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT 165 Q+ +G+ + HS ++++RDLKP N+ + +K+ DFGL + + T T Sbjct: 126 ELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKR-TRSKGT 184 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMV 197 L Y +PE + + Y VD+++LG I AE++ Sbjct: 185 LRYMSPE-QISSQDYGKEVDLYALGLILAELL 215 >6ED6-A nrPDB Length = 415 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 102/220 (46%), Gaps = 9/220 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNH 60 E++ V+ IG G +G V R+K + +V A+K + + + + E ++ N Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 147 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 P +V+L + LY+V E++ DL M + +P K Y +++ L H Sbjct: 148 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLM---SNYDVPEKWAKFYTAEVVLALDAIH 204 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILL--- 175 S ++HRD+KP N+L++ G +KLADFG + V T Y +PE+L Sbjct: 205 SMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG 264 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRI 215 G +Y D WS+G EM+ F DS + +I Sbjct: 265 GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKI 304 >2PL0-A nrPDB Length = 289 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 67/260 (25%), Positives = 125/260 (48%), Gaps = 36/260 (13%) Query: 2 ENFQKVEKIGEGTYGVV----YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKE 57 E + VE++G G +G V Y K VA+K ++ + + P + E +L+K+ Sbjct: 23 ETLKLVERLGAGQFGEVWMGYYNGHTK-----VAVKSLKQGSMS---PDAFLAEANLMKQ 74 Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 L H +V+L V+ T+ +Y++ E++ L F+ + + + + Q+ +G+A Sbjct: 75 LQHQRLVRLYAVV-TQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 133 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE---VVTLWYRAPEI 173 F +HRDL+ N+L++ + K+ADFGLAR + YT + + APE Sbjct: 134 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARL--IEDNEYTAREGAKFPIKWTAPEA 191 Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVTR-RALFPGDS------EIDQLFRIFRTLGTPDE-- 224 + ++ D+WS G + E+VT R +PG + +++ +R+ R P+E Sbjct: 192 -INYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELY 250 Query: 225 ----VVWPGVTSMPDYKPSF 240 + W P+ +P+F Sbjct: 251 QLMRLCW---KERPEDRPTF 267 >5B2L-A nrPDB Length = 324 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 58/206 (28%), Positives = 96/206 (46%), Gaps = 13/206 (6%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 + + + + ++G GT G V+K R + TG V+A+K++R E + +LK + Sbjct: 16 INDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDC 75 Query: 61 PNIVKLLDVIHTENKLYLVFEFLH---QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 P IV+ T +++ E + + LKK M IP ++ +++ L + Sbjct: 76 PYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGP----IPERILGKMTVAIVKALYY 131 Query: 118 C-HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL- 175 H V+HRD+KP N+L++ G IKL DFG++ V + T Y APE + Sbjct: 132 LKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRL-VDSKAKTRSAGCAAYMAPERIDP 190 Query: 176 ---GCKYYSTAVDIWSLGCIFAEMVT 198 Y D+WSLG E+ T Sbjct: 191 PDPTKPDYDIRADVWSLGISLVELAT 216 >6FER-A nrPDB Length = 309 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 77/291 (26%), Positives = 124/291 (42%), Gaps = 38/291 (13%) Query: 8 EKIGEGTYGVVY----KARNKLTGE------------VVALKKIRLDTETEGVPSTAIRE 51 EK+GEG +G V+ + K + +VA+K +R D + + ++E Sbjct: 15 EKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADA-NKNARNDFLKE 73 Query: 52 ISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMD--------ASALTGIPLP 102 I ++ L PNI+ LL V T++ L ++ E++ DL +F+ +S + + Sbjct: 74 IKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYT 133 Query: 103 LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYT 160 +K Q+ G+ + S +HRDL +N L+ IK+ADFG++R G R Sbjct: 134 NLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQG 193 Query: 161 HEVVTL-WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFP-----GDSEIDQLFR 214 V+ + W ILLG ++TA D+W+ G E T P + I+ Sbjct: 194 RAVLPIRWMSWESILLG--KFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGE 251 Query: 215 IFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQ 265 FR G + P + YK W R +K P E LL Q Sbjct: 252 FFRDQGRQTYLPQPAICPDSVYKLMLSCWRRD--TKNRPSFQEIHLLLLQQ 300 >1ZWS-A nrPDB Length = 288 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 81/308 (26%), Positives = 144/308 (46%), Gaps = 41/308 (13%) Query: 1 MENFQKV-EKIGEGTYGVVYKARNKLTG-EVVA--LKKIRLDTETEGVPSTAI-REISLL 55 +E+F + E++G G + +V K R K TG E A +KK + GV I RE+S+L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSIL 69 Query: 56 KELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQG 114 +++ H N++ L DV + L+ E + +L F+ + + S++ Q+L G Sbjct: 70 RQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFL--AQKESLSEEEATSFIKQILDG 127 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 + + H+ ++ H DLKP+N+++ + IKL DFGLA V + + T + A Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVA 186 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 PEI+ + D+WS+G I +++ + F GD++ + L + Sbjct: 187 PEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETL---------------ANI 230 Query: 231 TSMP-DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 TS+ D+ F FS E + + ++L + KR++ + AL HP+ V Sbjct: 231 TSVSYDFDEEF-------FSHT----SELAKDFIRKLLVKETRKRLTIQEALRHPWITPV 279 Query: 290 TKPVPHLR 297 +R Sbjct: 280 DNQQAMVR 287 >4WUA-A nrPDB Length = 401 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 72/262 (27%), Positives = 116/262 (44%), Gaps = 69/262 (26%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL----- 58 + + K+G G + V+ + + + VA+K ++ E TA+ EI LLK + Sbjct: 43 YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK---SAEHYTETALDEIRLLKSVRNSDP 99 Query: 59 NHPN---IVKLLDVIHTEN----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQL 111 N PN +V+LLD + +VFE L L K++ S G+PLP +K + Q+ Sbjct: 100 NDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQV 159 Query: 112 LQGLAFCHSH-RVLHRDLKPQNLLINTE-----------------GA------------- 140 LQGL + H+ R++H D+KP+N+L++ GA Sbjct: 160 LQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPA 219 Query: 141 -------------------IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 +K+AD G A + +T ++ T YR+ E+L+G Y+ Sbjct: 220 TAGNFLVNPLEPKNAEKLKVKIADLGNACWVH---KHFTEDIQTRQYRSLEVLIGSG-YN 275 Query: 182 TAVDIWSLGCIFAEMVTRRALF 203 T DIWS C+ E+ T LF Sbjct: 276 TPADIWSTACMAFELATGDYLF 297 >5VO2-A nrPDB Length = 300 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 59/200 (29%), Positives = 96/200 (48%), Gaps = 20/200 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E ++ +G G G V+ R GE VA+KK+R ET+ I L++L HP Sbjct: 12 EEILDLQWVGSGAQGAVFLGR--FHGEEVAVKKVRDLKETD---------IKHLRKLKHP 60 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPL--PLIKSYLFQLLQGLAFC 118 NI+ V ++ EF Q L + + A G P+ L+ + + G+ + Sbjct: 61 NIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA----GRPVTPSLLVDWSMGIAGGMNYL 116 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 H H+++HRDLK N+LI + +K++DFG ++ + W APE++ + Sbjct: 117 HLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWM-APEVIRN-E 174 Query: 179 YYSTAVDIWSLGCIFAEMVT 198 S VDIWS G + E++T Sbjct: 175 PVSEKVDIWSFGVVLWELLT 194 >2A27-A nrPDB Length = 321 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 80/308 (25%), Positives = 145/308 (47%), Gaps = 41/308 (13%) Query: 1 MENFQKV-EKIGEGTYGVVYKARNKLTG-EVVA--LKKIRLDTETEGVPSTAI-REISLL 55 +E+F + E++G G + +V K R K TG E A +KK + GV I RE+S+L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSIL 69 Query: 56 KELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQG 114 +++ H N++ L DV + L+ E + +L F+ + + S++ Q+L G Sbjct: 70 RQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFL--AQKESLSEEEATSFIKQILDG 127 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 + + H+ ++ H DLKP+N+++ + IKL DFGLA V + + T + A Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVA 186 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 PEI + + D+WS+G I +++ + F GD++ + L + Sbjct: 187 PEI-VNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETL---------------ANI 230 Query: 231 TSMP-DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 T++ D+ F FS+ E + + ++L + KR++ + AL HP+ V Sbjct: 231 TAVSYDFDEEF-------FSQT----SELAKDFIRKLLVKETRKRLTIQEALRHPWITPV 279 Query: 290 TKPVPHLR 297 +R Sbjct: 280 DNQQAMVR 287 >5TQX-A nrPDB Length = 655 Score = 81.6 bits (200), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 63/201 (31%), Positives = 98/201 (48%), Gaps = 13/201 (6%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 E++G G +G V +++ +A+K RL+ T+ EI ++K+LNH N+VK Sbjct: 14 ERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWC-HEIQIMKKLNHANVVKAC 72 Query: 68 DVIHTENKL-----YLVFEFLHQ-DLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHS 120 DV N L L E+ DL+K ++ G+ I S L + G+ + H Sbjct: 73 DVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHE 132 Query: 121 HRVLHRDLKPQNLLINTEGAI---KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 ++++HRDLKP+N+++ G K+ D G A+ T V TL Y APE L Sbjct: 133 NKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQG-ELCTEFVGTLQYLAPE-LFEN 190 Query: 178 KYYSTAVDIWSLGCIFAEMVT 198 K Y+ VD WS G + E + Sbjct: 191 KPYTATVDYWSFGTMVFECIA 211 >3HDN-A nrPDB Length = 373 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 62/198 (31%), Positives = 100/198 (50%), Gaps = 6/198 (3%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTG---EVVALKKIRLDTETEGVPSTAIREISLLKELN 59 +F ++ IG+G++G V AR+K V L+K + + E + R + LLK + Sbjct: 39 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNV-LLKNVK 97 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 HP +V L T +KLY V ++++ + F P + Y ++ L + H Sbjct: 98 HPFLVGLHFSFQTADKLYFVLDYINGG-ELFYHLQRERCFLEPRARFYAAEIASALGYLH 156 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 S +++RDLKP+N+L++++G I L DFGL + T + T Y APE+L Y Sbjct: 157 SLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY 216 Query: 180 YSTAVDIWSLGCIFAEMV 197 T VD W LG + EM+ Sbjct: 217 DRT-VDWWCLGAVLYEML 233 >3UIU-A nrPDB Length = 306 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 110/225 (48%), Gaps = 38/225 (16%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 +F+++E IG G +G V+KA++++ G+ +++++ + E A RE+ L +L+H N Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEK------AEREVKALAKLDHVN 66 Query: 63 IVKL----------------------LDVIHTENK-------LYLVFEFLHQD-LKKFMD 92 IV D +++N L++ EF + L+++++ Sbjct: 67 IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIE 126 Query: 93 ASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF 152 + L Q+ +G+ + HS +++HRDLKP N+ + +K+ DFGL + Sbjct: 127 KRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 186 Query: 153 GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMV 197 + T TL Y +PE + + Y VD+++LG I AE++ Sbjct: 187 KNDGKR-TRSKGTLRYMSPE-QISSQDYGKEVDLYALGLILAELL 229 >6FEX-A nrPDB Length = 321 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 76/296 (25%), Positives = 130/296 (43%), Gaps = 39/296 (13%) Query: 8 EKIGEGTYGVVYKAR--------------NKLTGE--VVALKKIRLDTETEGVPSTAIRE 51 EK+GEG +G V+ N G +VA+K +R D T+ + ++E Sbjct: 22 EKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDA-TKNARNDFLKE 80 Query: 52 ISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTG-----------I 99 + ++ L PNI++LL V ++ L ++ +++ DL +F+ A L I Sbjct: 81 VKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDPTI 140 Query: 100 PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVR 157 P++ Q+ G+ + + +HRDL +N L+ IK+ADFG++R G R Sbjct: 141 SYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYR 200 Query: 158 TYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAE--MVTRRALF---PGDSEIDQL 212 V+ + + A E +L K ++TA D+W+ G E M+ R F + I+ Sbjct: 201 VQGRAVLPIRWMAWECILMGK-FTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENA 259 Query: 213 FRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLH 268 FR G + P Y+ W+R+ S+ PP + R L L+ Sbjct: 260 GEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRE--SEQRPPFSQLHRFLAEDALN 313 >5SYS-A nrPDB Length = 286 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 63/223 (28%), Positives = 112/223 (50%), Gaps = 16/223 (7%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 K+G+G +G + T V A+K ++ T + P ++E ++K+L H +V+L Sbjct: 25 KLGQGCFGECWMGTWNGTTRV-AIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 80 Query: 69 VIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 V+ +E +Y+V E++ + L F+ + LP + Q+ G+A+ +HRD Sbjct: 81 VV-SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 139 Query: 128 LKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT---LWYRAPEILLGCKYYSTAV 184 L+ N+L+ K+ADFGLAR + YT + + APE L + ++ Sbjct: 140 LRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR-FTIKS 196 Query: 185 DIWSLGCIFAEMVTR-RALFPG--DSEI-DQLFRIFRTLGTPD 223 D+WS G + E+ T+ R +PG + E+ DQ+ R +R P+ Sbjct: 197 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE 239 >3SXS-A nrPDB Length = 268 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 69/271 (25%), Positives = 130/271 (47%), Gaps = 26/271 (9%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEV-VALKKIRLDTETEGVPSTAIREISLLKELNH 60 E ++++G G +GVV K G+ VA+K I+ + +E +E + +L+H Sbjct: 8 EEITLLKELGSGQFGVV--KLGKWKGQYDVAVKMIKEGSMSE---DEFFQEAQTMMKLSH 62 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 P +VK V E +Y+V E++ S G+ + + + +G+AF S Sbjct: 63 PKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLES 122 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILLGC 177 H+ +HRDL +N L++ + +K++DFG+ R V Y V T + + APE+ Sbjct: 123 HQFIHRDLAARNCLVDRDLCVKVSDFGMTRY--VLDDQYVSSVGTKFPVKWSAPEVFHYF 180 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRAL---FPGDSE----IDQLFRIFRTLGTPD---EVVW 227 K YS+ D+W+ G + E+ + + +SE + Q R++R D ++++ Sbjct: 181 K-YSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMY 239 Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDED 258 +P+ +P+F +Q S + P ++D Sbjct: 240 SCWHELPEKRPTF----QQLLSSIEPLREKD 266 >2PSQ-A nrPDB Length = 370 Score = 80.5 bits (197), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 61/233 (26%), Positives = 113/233 (48%), Gaps = 27/233 (11%) Query: 10 IGEGTYGVVYKA------RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPN 62 +GEG +G V A ++K V K+ D TE S + E+ ++K + H N Sbjct: 89 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 148 Query: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPL--------------IKSY 107 I+ LL + LY++ E+ + +L++++ A G+ + S Sbjct: 149 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 208 Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYTHEVVT 165 +QL +G+ + S + +HRDL +N+L+ +K+ADFGLAR + T+ + Sbjct: 209 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 268 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFR 217 + + APE L + Y+ D+WS G + E+ T + +PG +++LF++ + Sbjct: 269 VKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPG-IPVEELFKLLK 319 >4OTD-A nrPDB Length = 341 Score = 80.5 bits (197), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 73/235 (31%), Positives = 118/235 (50%), Gaps = 18/235 (7%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR-----LDTETEGVPSTAIREISLL 55 +E+F+ + +G G +G V + + +GE+ A+K ++ E E + R ++ + Sbjct: 11 LEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK-RILAAV 69 Query: 56 KELNHPNIVKLLDVIHTENKLYLVFEF-LHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 HP +V L T + V E+ DL + + + P Y ++ G Sbjct: 70 TSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSE---PRAIFYSACVVLG 126 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLAR-AFGVPVRTYTHEVVTLWYRAPEI 173 L F H H++++RDLK NLL++TEG +K+ADFGL + G RT T T + APE+ Sbjct: 127 LQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTF-CGTPEFLAPEV 185 Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228 L Y+ AVD W LG + EM+ + FPGD E + +F ++ DEV +P Sbjct: 186 LTDTS-YTRAVDWWGLGVLLYEMLVGESPFPGDDEEE----VFDSI-VNDEVRYP 234 >5UUU-A nrPDB Length = 547 Score = 80.5 bits (197), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 135/300 (45%), Gaps = 42/300 (14%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIRE---ISLLK 56 M +F IG G +G VY R TG++ A+K + + + + + A+ E +SL+ Sbjct: 197 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 256 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 + P IV + HT +KL + + ++ DL + + ++ Y +++ GL Sbjct: 257 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEIILGL 314 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEIL 174 H+ V++RDLKP N+L++ G ++++D GLA F + H V T Y APE+L Sbjct: 315 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS---KKKPHASVGTHGYMAPEVL 371 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 Y ++ D +SLGC+ +++ + F D+ D + +P Sbjct: 372 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK--------HEIDRMTLTMAVELP 423 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDV 289 D FS P L RSLL +L D N+R+ A+ PFF+ + Sbjct: 424 D-----------SFS---PEL----RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 465 >5EG3-A nrPDB Length = 334 Score = 80.5 bits (197), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 63/233 (27%), Positives = 114/233 (48%), Gaps = 27/233 (11%) Query: 10 IGEGTYGVVYKA------RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPN 62 +GEG +G V A ++K V K+ D TE S + E+ ++K + H N Sbjct: 43 LGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 102 Query: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPL-PLIK-------------SY 107 I+ LL + LY++ + + +L++++ A G+ L P I S Sbjct: 103 IINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMTFKDLVSC 162 Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYTHEVVT 165 +QL +G+ + S + +HRDL +N+L+ +K+ADFGLAR + T+ + Sbjct: 163 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFKETTNGRLP 222 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFR 217 + + APE L + Y+ D+WS G + E+ T + +PG +++LF++ + Sbjct: 223 VKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPG-IPVEELFKLLK 273 >2X7G-A nrPDB Length = 389 Score = 80.5 bits (197), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 93/363 (25%), Positives = 148/363 (40%), Gaps = 86/363 (23%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK-----EL 58 + + K+G G + V+ + VA+K ++ + TA+ EI LLK + Sbjct: 33 YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK---SAQHYTETALDEIKLLKCVRESDP 89 Query: 59 NHPN---IVKLLD--VIHTENKLY--LVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQL 111 + PN +V+L+D I N ++ +VFE L L K++ S G+P+ +KS + Q+ Sbjct: 90 SDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQV 149 Query: 112 LQGLAFCHSH-RVLHRDLKPQNLLINTEGA------------------------------ 140 LQGL + HS +++H D+KP+N+L+ + A Sbjct: 150 LQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPA 209 Query: 141 -----------------IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 +K+AD G A + +T ++ T YR+ E+L+G YST Sbjct: 210 ADLLVNPLDPRNADKIRVKIADLGNACWVH---KHFTEDIQTRQYRSIEVLIGAG-YSTP 265 Query: 184 VDIWSLGCIFAEMVTRRALFPGDS------EIDQLFRIFRTLGT-PDEVVWPGVTSMPDY 236 DIWS C+ E+ T LF S + D + I LG+ P G S + Sbjct: 266 ADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFF 325 Query: 237 K--------PSFPKWARQD--FSKVVPPLDEDGR--SLLSQMLHYDPNKRISAKAALAHP 284 W+ D K P ++ + L ML P KR SA L HP Sbjct: 326 NRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHP 385 Query: 285 FFQ 287 + Sbjct: 386 WLN 388 >3PVW-A nrPDB Length = 695 Score = 80.5 bits (197), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 135/300 (45%), Gaps = 42/300 (14%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIRE---ISLLK 56 M +F IG G +G VY R TG++ A+K + + + + + A+ E +SL+ Sbjct: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 + P IV + HT +KL + + ++ DL + + ++ Y +++ GL Sbjct: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEIILGL 305 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEIL 174 H+ V++RDLKP N+L++ G ++++D GLA F + H V T Y APE+L Sbjct: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS---KKKPHASVGTHGYMAPEVL 362 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 Y ++ D +SLGC+ +++ + F D+ D + +P Sbjct: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK--------HEIDRMTLTMAVELP 414 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDV 289 D FS P L RSLL +L D N+R+ A+ PFF+ + Sbjct: 415 D-----------SFS---PEL----RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 >2XYN-A nrPDB Length = 292 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 98/201 (48%), Gaps = 9/201 (4%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKELNHPNIVKLL 67 K+G G YG VY K VA+K ++ DT E E ++E +++KE+ HPN+V+LL Sbjct: 39 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEF----LKEAAVMKEIKHPNLVQLL 94 Query: 68 DVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 V E Y+V E++ + +L ++ + ++ Q+ + + +HR Sbjct: 95 GVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHR 154 Query: 127 DLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVD 185 DL +N L+ +K+ADFGL+R G + + + APE L +S D Sbjct: 155 DLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES-LAYNTFSIKSD 213 Query: 186 IWSLGCIFAEMVTR-RALFPG 205 +W+ G + E+ T + +PG Sbjct: 214 VWAFGVLLWEIATYGMSPYPG 234 >4PWN-A nrPDB Length = 274 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 80/293 (27%), Positives = 135/293 (46%), Gaps = 49/293 (16%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 +IG G++ VYK + T VA +++ T+ E +LK L HPNIV+ D Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYD 76 Query: 69 ----VIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR- 122 + + + LV E + LK ++ + + + +++S+ Q+L+GL F H+ Sbjct: 77 SWESTVKGKKCIVLVTELMTSGTLKTYLKRFKV--MKIKVLRSWCRQILKGLQFLHTRTP 134 Query: 123 -VLHRDLKPQNLLINT-EGAIKLADFGLA----RAFGVPVRTYTHEVV-TLWYRAPEILL 175 ++HRDLK N+ I G++K+ D GLA RA ++ V+ T + APE+ Sbjct: 135 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRA------SFAKSVIGTPEFMAPEMYE 188 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 + Y +VD+++ G EM T + SE +I+R V GV Sbjct: 189 --EKYDESVDVYAFGMCMLEMATSEYPY---SECQNAAQIYRR-------VTSGV----- 231 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 KP+ F KV P + + ++ + + ++R S K L H FFQ+ Sbjct: 232 -KPA-------SFDKVAIP---EVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >1LUF-A nrPDB Length = 343 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 59/225 (26%), Positives = 101/225 (44%), Gaps = 30/225 (13%) Query: 3 NFQKVEKIGEGTYGVVYKARNK--LTGEVVALKKIRLDTETEGVPSTA--IREISLLKEL 58 N + V IGEG +G V++AR L E + +++ E A RE +L+ E Sbjct: 48 NIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEF 107 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFL---------------------HQDLKKFMDASALT 97 ++PNIVKLL V + L+FE++ H DL S+ Sbjct: 108 DNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPG 167 Query: 98 GIPLPLIKSYLF--QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP 155 PL + Q+ G+A+ + +HRDL +N L+ +K+ADFGL+R Sbjct: 168 PPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA 227 Query: 156 --VRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 + ++ + + + PE + + Y+T D+W+ G + E+ + Sbjct: 228 DYYKADGNDAIPIRWMPPESIFYNR-YTTESDVWAYGVVLWEIFS 271 >4FR4-A nrPDB Length = 384 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 73/295 (24%), Positives = 137/295 (46%), Gaps = 36/295 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIREISLLKELNH 60 ++F+ + IG+G++G V + T ++ A+K + E +E+ +++ L H Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 74 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 P +V L E +++V + L DL+ + + +K ++ +L+ L + Sbjct: 75 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV--HFKEETVKLFICELVMALDYLQ 132 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY-THEVVTLWYRAPEILLGCK 178 + R++HRD+KP N+L++ G + + DF +A +P T T T Y APE+ K Sbjct: 133 NQRIIHRDMKPDNILLDEHGHVHITDFNIAAM--LPRETQITTMAGTKPYMAPEMFSSRK 190 Query: 179 --YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 YS AVD WSLG E++ R + R+ + E+V T++ Y Sbjct: 191 GAGYSFAVDWWSLGVTAYELLRGRRPYH-----------IRSSTSSKEIVHTFETTVVTY 239 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAH-PFFQDVT 290 PS W+++ SLL ++L +P++R S + + + P+ D+ Sbjct: 240 -PS--AWSQEMV------------SLLKKLLEPNPDQRFSQLSDVQNFPYMNDIN 279 >4EBW-A nrPDB Length = 304 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 60/214 (28%), Positives = 114/214 (53%), Gaps = 14/214 (6%) Query: 10 IGEGTYGVVYKA---RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 IGEG +G V++ + VA+K + + ++ V ++E +++ +HP+IVKL Sbjct: 46 IGEGQFGDVHQGIYMSPENPALAVAIKTCK-NCTSDSVREKFLQEALTMRQFDHPHIVKL 104 Query: 67 LDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 125 + VI TEN ++++ E +L+ F+ + + L + Y +QL LA+ S R +H Sbjct: 105 IGVI-TENPVWIIMELCTLGELRSFLQVRKYS-LDLASLILYAYQLSTALAYLESKRFVH 162 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY---THEVVTLWYRAPEILLGCKYYST 182 RD+ +N+L+++ +KL DFGL+R + TY + + + + APE + + +++ Sbjct: 163 RDIAARNVLVSSNDCVKLGDFGLSRY--MEDSTYYKASKGKLPIKWMAPES-INFRRFTS 219 Query: 183 AVDIWSLG-CIFAEMVTRRALFPGDSEIDQLFRI 215 A D+W G C++ ++ F G D + RI Sbjct: 220 ASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 253 >2J0K-A nrPDB Length = 656 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 60/214 (28%), Positives = 113/214 (52%), Gaps = 14/214 (6%) Query: 10 IGEGTYGVVYKA---RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 IGEG +G V++ + VA+K + + ++ V ++E +++ +HP+IVKL Sbjct: 398 IGEGQFGDVHQGIYMSPENPAMAVAIKTCK-NCTSDSVREKFLQEALTMRQFDHPHIVKL 456 Query: 67 LDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 125 + VI TEN ++++ E +L+ F+ + + L + Y +QL LA+ S R +H Sbjct: 457 IGVI-TENPVWIIMELCTLGELRSFLQVRKFS-LDLASLILYAYQLSTALAYLESKRFVH 514 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY---THEVVTLWYRAPEILLGCKYYST 182 RD+ +N+L++ +KL DFGL+R + TY + + + + APE + + +++ Sbjct: 515 RDIAARNVLVSATDCVKLGDFGLSRY--MEDSTYYKASKGKLPIKWMAPES-INFRRFTS 571 Query: 183 AVDIWSLG-CIFAEMVTRRALFPGDSEIDQLFRI 215 A D+W G C++ ++ F G D + RI Sbjct: 572 ASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 605 >4CRS-A nrPDB Length = 341 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 83/298 (27%), Positives = 136/298 (45%), Gaps = 45/298 (15%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL-DTETEGVPSTAIREISLLKELN 59 +++F+ + G +G V A K T E+ A+K ++ D + + E + + +N Sbjct: 11 LQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVN 70 Query: 60 ---HPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 HP +V L T+ + V E+ DL + + P Y ++ GL Sbjct: 71 SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSE---PRAVFYAACVVLGL 127 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLAR-AFGVPVRTYTHEVVTLWYRAPEIL 174 + H H++++RDLK NLL++TEG +K+ADFGL + G RT T T + APE+L Sbjct: 128 QYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTF-CGTPEFLAPEVL 186 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 Y+ AVD W LG + EM+ + FPGD E + +F ++ DEV +P S Sbjct: 187 TETS-YTRAVDWWGLGVLIYEMLVGESPFPGDDEEE----VFDSI-VNDEVRYPRFLST- 239 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA-----HPFFQ 287 + S++ ++L +P +R+ A A HPFF+ Sbjct: 240 -----------------------EAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFR 274 >3LM0-A nrPDB Length = 327 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 75/303 (24%), Positives = 140/303 (46%), Gaps = 49/303 (16%) Query: 1 MENFQKV-----EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLL 55 MENF +++G G + VV + +K TG+ A K ++ + + + EI++L Sbjct: 23 MENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVL 82 Query: 56 K-ELNHPNIVKLLDVIHTENKLYLVFEFLHQD------LKKFMDASALTGIPLPLIKSYL 108 + + P ++ L +V +++ L+ E+ L + + + + + LIK Sbjct: 83 ELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDV-IRLIK--- 138 Query: 109 FQLLQGLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVV- 164 Q+L+G+ + H + ++H DLKPQN+L+++ G IK+ DFG++R G E++ Sbjct: 139 -QILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACE--LREIMG 195 Query: 165 TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDE 224 T Y APEI L +TA D+W++G I ++T + F G+ + I + E Sbjct: 196 TPEYLAPEI-LNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSE 254 Query: 225 VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284 + V+ + DF + +L +P KR +A+ L+H Sbjct: 255 ETFSSVSQLA-----------TDF--------------IQSLLVKNPEKRPTAEICLSHS 289 Query: 285 FFQ 287 + Q Sbjct: 290 WLQ 292 >5U6B-A nrPDB Length = 307 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 71/286 (24%), Positives = 132/286 (46%), Gaps = 50/286 (17%) Query: 10 IGEGTYGVVYKARNKLTGEV--VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 +GEG +G V + + + VA+K +++ T + E +KE +HPN+++L+ Sbjct: 31 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 90 Query: 68 DVIH--TENKLY----LVFEFL-HQDLKKFMDASALTG----IPLPLIKSYLFQLLQGLA 116 V +E + + ++ F+ H DL F+ S L +P ++ ++ + G+ Sbjct: 91 GVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGME 150 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL-- 174 + + R +HRDL +N ++N ++ +ADFGL++ + Y + +YR I Sbjct: 151 YLSTKRFIHRDLAARNCMLNENMSVCVADFGLSK------KIYNGD----YYRQGRIAKM 200 Query: 175 ---------LGCKYYSTAVDIWSLGCIFAEMVTR-RALFPG--DSEIDQLFRIFRTLGTP 222 L + Y++ D+WS G E+ TR + +PG +SEI R L P Sbjct: 201 PVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQP 260 Query: 223 DEVVWPGVTSM--------PDYKPSFPKWARQDFS---KVVPPLDE 257 + + G+ ++ P +PSF + R+D K +PP E Sbjct: 261 ADCL-DGLYALMSRCWELNPQDRPSFTE-LREDLENTLKALPPAQE 304 >5TUR-A nrPDB Length = 404 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 69/242 (28%), Positives = 111/242 (45%), Gaps = 15/242 (6%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIR---EISLLKELNH--PNI 63 +G G +G VY VA+K + D ++ G R E+ LLK+++ + Sbjct: 135 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 194 Query: 64 VKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 ++LLD + L+ E QDL F+ + L +S+ +Q+L+ + CH+ Sbjct: 195 IRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHNC 252 Query: 122 RVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 VLHRD+K +N+LI+ G +KL DFG V YT T Y PE + +Y+ Sbjct: 253 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWIRYHRYH 310 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEI--DQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 + +WSLG + +MV F D EI Q+F R ++ + P +P Sbjct: 311 GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRP 370 Query: 239 SF 240 +F Sbjct: 371 TF 372 >4RC3-A nrPDB Length = 289 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 69/242 (28%), Positives = 111/242 (45%), Gaps = 15/242 (6%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIR---EISLLKELNH--PNI 63 +G G +G VY VA+K + D ++ G R E+ LLK+++ + Sbjct: 20 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 79 Query: 64 VKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 ++LLD + L+ E QDL F+ + L +S+ +Q+L+ + CH+ Sbjct: 80 IRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHNC 137 Query: 122 RVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 VLHRD+K +N+LI+ G +KL DFG V YT T Y PE + +Y+ Sbjct: 138 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWIRYHRYH 195 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEI--DQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 + +WSLG + +MV F D EI Q+F R ++ + P +P Sbjct: 196 GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRP 255 Query: 239 SF 240 +F Sbjct: 256 TF 257 >3BGP-A nrPDB Length = 333 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 69/242 (28%), Positives = 111/242 (45%), Gaps = 15/242 (6%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIR---EISLLKELNH--PNI 63 +G G +G VY VA+K + D ++ G R E+ LLK+++ + Sbjct: 64 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 123 Query: 64 VKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 ++LLD + L+ E QDL F+ + L +S+ +Q+L+ + CH+ Sbjct: 124 IRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHNC 181 Query: 122 RVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 VLHRD+K +N+LI+ G +KL DFG V YT T Y PE + +Y+ Sbjct: 182 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWIRYHRYH 239 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEI--DQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 + +WSLG + +MV F D EI Q+F R ++ + P +P Sbjct: 240 GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRP 299 Query: 239 SF 240 +F Sbjct: 300 TF 301 >5MJB-A nrPDB Length = 305 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 107/206 (51%), Gaps = 13/206 (6%) Query: 3 NFQKVEK-IGEGTYGVVYKARNKLTGE---VVALKKIRLDTETEGVPSTAIREISLLKEL 58 +F K+E+ IG G +G VYK R KL G+ VA+K ++ +E + E S++ + Sbjct: 26 SFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-SEKQRRDFLSEASIMGQF 84 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 +H NI++L V+ + ++ EF+ L F+ + + L+ L + G+ + Sbjct: 85 DHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLV-GMLRGIAAGMKY 143 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR--TYTHEV---VTLWYRAPE 172 +HRDL +N+L+N+ K++DFGL+R TYT + + + + APE Sbjct: 144 LSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPE 203 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVT 198 + + +++A D+WS G + E+++ Sbjct: 204 -AIAYRKFTSASDVWSYGIVMWEVMS 228 >1U54-B nrPDB Length = 291 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 60/206 (29%), Positives = 99/206 (48%), Gaps = 13/206 (6%) Query: 2 ENFQKVEKIGEGTYGVVYKAR-NKLTGEVVALKKIRLDTETEGVPSTA---IREISLLKE 57 ++ + +EK+G+G++GVV + + +G+ V++ L + P IRE++ + Sbjct: 18 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 77 Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDA--SALTGIPLPLIKSYLFQLLQGL 115 L+H N+++L V+ T + +V E L +D L + Y Q+ +G+ Sbjct: 78 LDHRNLIRLYGVVLTP-PMKMVTEL--APLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 134 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT---HEVVTLWYRAPE 172 + S R +HRDL +NLL+ T +K+ DFGL RA Y H V + APE Sbjct: 135 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 194 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVT 198 L + +S A D W G EM T Sbjct: 195 S-LKTRTFSHASDTWMFGVTLWEMFT 219 >4HZS-A nrPDB Length = 341 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 60/206 (29%), Positives = 99/206 (48%), Gaps = 13/206 (6%) Query: 2 ENFQKVEKIGEGTYGVVYKAR-NKLTGEVVALKKIRLDTETEGVPSTA---IREISLLKE 57 ++ + +EK+G+G++GVV + + +G+ V++ L + P IRE++ + Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 71 Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDA--SALTGIPLPLIKSYLFQLLQGL 115 L+H N+++L V+ T + +V E L +D L + Y Q+ +G+ Sbjct: 72 LDHRNLIRLYGVVLTP-PMKMVTEL--APLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 128 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT---HEVVTLWYRAPE 172 + S R +HRDL +NLL+ T +K+ DFGL RA Y H V + APE Sbjct: 129 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 188 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVT 198 L + +S A D W G EM T Sbjct: 189 S-LKTRTFSHASDTWMFGVTLWEMFT 213 >4G3E-A nrPDB Length = 352 Score = 78.2 bits (191), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 57/197 (28%), Positives = 97/197 (49%), Gaps = 17/197 (8%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 ++G G++G V++ ++K TG A+KK+RL+ + E+ L+ P IV L Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRLEV-------FRVEELVACAGLSSPRIVPLYG 133 Query: 69 VIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 + + + E L L + + + +P YL Q L+GL + H+ R+LH D Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLI--KQMGCLPEDRALYYLGQALEGLEYLHTRRILHGD 191 Query: 128 LKPQNLLINTEGA-IKLADFGLA-----RAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 +K N+L++++G+ L DFG A G + T + T + APE+++G K Sbjct: 192 VKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-KPCD 250 Query: 182 TAVDIWSLGCIFAEMVT 198 VDIWS C+ M+ Sbjct: 251 AKVDIWSSCCMMLHMLN 267 >3PPZ-A nrPDB Length = 309 Score = 78.2 bits (191), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 59/196 (30%), Positives = 102/196 (52%), Gaps = 9/196 (4%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHPNIVKL 66 EKIG G++G V++A + G VA+K + D E V + +RE++++K L HPNIV Sbjct: 43 EKIGAGSFGTVHRA--EWHGSDVAVKILMEQDFHAERV-NEFLREVAIMKRLRHPNIVLF 99 Query: 67 LDVIHTENKLYLVFEFLHQ-DLKKFMDAS-ALTGIPLPLIKSYLFQLLQGLAFCHSHR-- 122 + + L +V E+L + L + + S A + S + + +G+ + H+ Sbjct: 100 MGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPP 159 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182 ++HRDLK NLL++ + +K+ DFGL+R + T + APE+L + + Sbjct: 160 IVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRD-EPSNE 218 Query: 183 AVDIWSLGCIFAEMVT 198 D++S G I E+ T Sbjct: 219 KSDVYSFGVILWELAT 234 >5A46-A nrPDB Length = 386 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 118/236 (50%), Gaps = 33/236 (13%) Query: 10 IGEGTYGVVYKAR---------NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59 +GEG +G V A N++T VA+K ++ D TE S I E+ ++K + Sbjct: 48 LGEGCFGQVVLAEAIGLDKDKPNRVTK--VAVKMLKSDA-TEKDLSDLISEMEMMKMIGK 104 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSY----------- 107 H NI+ LL + LY++ E+ + +L++++ A G+ S+ Sbjct: 105 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 164 Query: 108 ---LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG--VPVRTYTHE 162 +Q+ +G+ + S + +HRDL +N+L+ + +K+ADFGLAR + T+ Sbjct: 165 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 224 Query: 163 VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFR 217 + + + APE L + Y+ D+WS G + E+ T + +PG +++LF++ + Sbjct: 225 RLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLK 278 >5O2B-A nrPDB Length = 285 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 76/291 (26%), Positives = 135/291 (46%), Gaps = 42/291 (14%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 ++G G + VYK + T VA +++ T+ E +LK L HPNIV+ D Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 69 ----VIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR- 122 ++ + + LV E + LK ++ + + +++S+ Q+L+GL F H+ Sbjct: 83 SWESILKGKKCIVLVTELMTSGTLKTYLKRFKV--MKPKVLRSWCRQILKGLQFLHTRTP 140 Query: 123 -VLHRDLKPQNLLINT-EGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGCKY 179 ++HRDLK N+ I G++K+ D GLA ++ V+ T + APE+ ++ Sbjct: 141 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT---SFAKSVIGTPEFMAPEMYE--EH 195 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 Y +VD+++ G EM T + SE +I+R VTS KP+ Sbjct: 196 YDESVDVYAFGMCMLEMATSEYPY---SECQNAAQIYRK-----------VTS--GIKPA 239 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 F+KV P + + ++ + + ++R+S + L H FF + T Sbjct: 240 -------SFNKVTDP---EVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT 280 >1TKI-A nrPDB Length = 321 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 70/297 (23%), Positives = 139/297 (46%), Gaps = 36/297 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELNH 60 E + E +G G +G+V++ + + K +++ +G ++ EIS+L H Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKV----KGTDQVLVKKEISILNIARH 60 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 NI+ L + + +L ++FEF+ D+ + ++ SA ++ SY+ Q+ + L F H Sbjct: 61 RNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIV-SYVHQVCEALQFLH 119 Query: 120 SHRVLHRDLKPQNLLINT--EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 SH + H D++P+N++ T IK+ +FG AR P + Y APE+ Sbjct: 120 SHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLK-PGDNFRLLFTAPEYYAPEV-HQH 177 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 STA D+WSLG + +++ + P +E +Q + ++ + + Sbjct: 178 DVVSTATDMWSLGTLVYVLLS--GINPFLAETNQQI----------------IENIMNAE 219 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 +F + A ++ S + +D + ++L + R++A AL HP+ + + V Sbjct: 220 YTFDEEAFKEIS--IEAMD-----FVDRLLVKERKSRMTASEALQHPWLKQKIERVS 269 >6BSD-A nrPDB Length = 876 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 77/302 (25%), Positives = 131/302 (43%), Gaps = 45/302 (14%) Query: 8 EKIGEGTYGVVYKAR--------------NKLTGE--VVALKKIRLDTETEGVPSTAIRE 51 EK+GEG +G V+ N G +VA+K +R D T+ + ++E Sbjct: 577 EKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDA-TKNARNDFLKE 635 Query: 52 ISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFM---------------DASA 95 + ++ L PNI++LL V ++ L ++ +++ DL +F+ D A Sbjct: 636 VKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQA 695 Query: 96 LTG--IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF- 152 G I P++ Q+ G+ + + +HRDL +N L+ IK+ADFG++R Sbjct: 696 AQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLY 755 Query: 153 -GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAE--MVTRRALF---PGD 206 G R V+ + + A E +L K ++TA D+W+ G E M+ R F + Sbjct: 756 AGDYYRVQGRAVLPIRWMAWECILMGK-FTTASDVWAFGVTLWEVLMLCRAQPFGQLTDE 814 Query: 207 SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQM 266 I+ FR G + P Y+ W+R+ S+ PP + R L Sbjct: 815 QVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRE--SEQRPPFSQLHRFLAEDA 872 Query: 267 LH 268 L+ Sbjct: 873 LN 874 >4AT3-A nrPDB Length = 299 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 101/209 (48%), Gaps = 22/209 (10%) Query: 9 KIGEGTYGVVYKARN-KLTGE----VVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 ++GEG +G V+ A L E +VA+K ++ ++ RE LL L H +I Sbjct: 20 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK--DASDNARKDFHREAELLTNLQHEHI 77 Query: 64 VKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGI-------PLPLIKSYLFQLLQ-- 113 VK V + L +VFE++ H DL KF+ A + P L +S + + Q Sbjct: 78 VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI 137 Query: 114 --GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYTHEVVTLWYR 169 G+ + S +HRDL +N L+ +K+ DFG++R R H ++ + + Sbjct: 138 AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM 197 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVT 198 PE ++ K ++T D+WSLG + E+ T Sbjct: 198 PPESIMYRK-FTTESDVWSLGVVLWEIFT 225 >5O2C-A nrPDB Length = 380 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 75/291 (25%), Positives = 135/291 (46%), Gaps = 42/291 (14%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 ++G G + VYK + T VA +++ T+ E +LK L HPNIV+ D Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 69 ----VIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR- 122 ++ + + LV E + LK ++ + + +++S+ Q+L+GL F H+ Sbjct: 92 SWESILKGKKCIVLVTELMTSGTLKTYLKRFKV--MKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 123 -VLHRDLKPQNLLINT-EGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGCKY 179 ++HRDLK N+ I G++K+ D GLA ++ V+ T + APE+ ++ Sbjct: 150 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT---SFAKSVIGTPEFMAPEMYE--EH 204 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 Y +VD+++ G EM T + SE +I+R V G+ KP+ Sbjct: 205 YDESVDVYAFGMCMLEMATSEYPY---SECQNAAQIYRK-------VTSGI------KPA 248 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 F+KV P + + ++ + + ++R+S + L H FF + T Sbjct: 249 -------SFNKVTDP---EVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT 289 >3GQL-A nrPDB Length = 326 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 118/236 (50%), Gaps = 33/236 (13%) Query: 10 IGEGTYGVVYKAR---------NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59 +GEG +G V A N++T VA+K ++ D TE S I E+ ++K + Sbjct: 36 LGEGAFGQVVLAEAIGLDKDKPNRVTK--VAVKMLKSDA-TEKDLSDLISEMEMMKMIGK 92 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPL--------------I 104 H NI+ LL + LY++ E+ + +L++++ A G+ + Sbjct: 93 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 152 Query: 105 KSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG--VPVRTYTHE 162 S +Q+ +G+ + S + +HRDL +N+L+ + +K+ADFGLAR + T+ Sbjct: 153 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 212 Query: 163 VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFR 217 + + + APE L + Y+ D+WS G + E+ T + +PG +++LF++ + Sbjct: 213 RLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLK 266 >3TT0-A nrPDB Length = 382 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 118/236 (50%), Gaps = 33/236 (13%) Query: 10 IGEGTYGVVYKAR---------NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59 +GEG +G V A N++T VA+K ++ D TE S I E+ ++K + Sbjct: 77 LGEGAFGQVVLAEAIGLDKDKPNRVTK--VAVKMLKSDA-TEKDLSDLISEMEMMKMIGK 133 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSY----------- 107 H NI+ LL + LY++ E+ + +L++++ A G+ S+ Sbjct: 134 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDL 193 Query: 108 ---LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG--VPVRTYTHE 162 +Q+ +G+ + S + +HRDL +N+L+ + +K+ADFGLAR + T+ Sbjct: 194 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 253 Query: 163 VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFR 217 + + + APE L + Y+ D+WS G + E+ T + +PG +++LF++ + Sbjct: 254 RLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKLLK 307 >3QD2-B nrPDB Length = 332 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 69/268 (25%), Positives = 113/268 (42%), Gaps = 73/268 (27%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 + +F+ ++ +G G +GVV++A+NK+ A+K+IRL E +RE+ L +L H Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNR-ELAREKVMREVKALAKLEH 63 Query: 61 PNIV---------------------------------------------KLLDVIHTEN- 74 P IV + +D T+N Sbjct: 64 PGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNT 123 Query: 75 ---------KLYLVFEFL---HQDLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSH 121 K+YL + ++LK +M+ +L + Q+ + + F HS Sbjct: 124 VGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSK 183 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFG---------VPV---RTYTHEVVTLWYR 169 ++HRDLKP N+ + +K+ DFGL A P+ T+T +V T Y Sbjct: 184 GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYM 243 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMV 197 +PE + G YS VDI+SLG I E++ Sbjct: 244 SPEQIHG-NNYSHKVDIFSLGLILFELL 270 >3ZZW-A nrPDB Length = 289 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 64/246 (26%), Positives = 118/246 (47%), Gaps = 31/246 (12%) Query: 7 VEKIGEGTYGVVYKAR--NKLTGE---VVALKKIRLDTETEGVPSTAIREISLLK-ELNH 60 +E++GE +G VYK GE VA+K ++ + EG R ++L+ L H Sbjct: 14 MEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLK--DKAEGPLREEFRHEAMLRARLQH 71 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFM--------------DASALTGIPLPLIK 105 PN+V LL V+ + L ++F + H DL +F+ D + + + P Sbjct: 72 PNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFV 131 Query: 106 SYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYTHEV 163 + Q+ G+ + SH V+H+DL +N+L+ + +K++D GL R + + + Sbjct: 132 HLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSL 191 Query: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFP----GDSEIDQLFRIFRTL 219 + + + APE ++ K +S DIWS G + E+ + L P + ++ ++ R + L Sbjct: 192 LPIRWMAPEAIMYGK-FSIDSDIWSYGVVLWEVFS-YGLQPYCGYSNQDVVEMIRNRQVL 249 Query: 220 GTPDEV 225 PD+ Sbjct: 250 PCPDDC 255 >4IDT-A nrPDB Length = 356 Score = 77.0 bits (188), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 57/197 (28%), Positives = 93/197 (47%), Gaps = 17/197 (8%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 ++G G++G V++ +K TG A+KK+RL+ E+ L P IV L Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEV-------FRAEELMACAGLTSPRIVPLYG 133 Query: 69 VIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 + + + E L L + + +P YL Q L+GL + HS R+LH D Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGC--LPEDRALYYLGQALEGLEYLHSRRILHGD 191 Query: 128 LKPQNLLINTEGA-IKLADFGLA-----RAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 +K N+L++++G+ L DFG A G + T + T + APE++LG + Sbjct: 192 VKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG-RSCD 250 Query: 182 TAVDIWSLGCIFAEMVT 198 VD+WS C+ M+ Sbjct: 251 AKVDVWSSCCMMLHMLN 267 >3C51-A nrPDB Length = 543 Score = 77.0 bits (188), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 74/291 (25%), Positives = 125/291 (42%), Gaps = 37/291 (12%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP-STAIREISLLKELNHPNIVKLLD 68 +G G +G V+ + K TG++ A KK+ + A+ E +L +++ IV L Sbjct: 193 LGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAY 252 Query: 69 VIHTENKLYLVFEFLHQDLKKF----MDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 T+ L LV ++ ++ +D G P Y Q++ GL H ++ Sbjct: 253 AFETKTDLCLVMTIMNGGDIRYHIYNVDEDN-PGFQEPRAIFYTAQIVSGLEHLHQRNII 311 Query: 125 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAV 184 +RDLKP+N+L++ +G ++++D GLA T + APE+LLG + Y +V Sbjct: 312 YRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLG-EEYDFSV 370 Query: 185 DIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWA 244 D ++LG EM+ R F E + + V+ VT + P A Sbjct: 371 DYFALGVTLYEMIAARGPFRARGEKVENKEL------KQRVLEQAVTYPDKFSP-----A 419 Query: 245 RQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDVT 290 +DF + +L DP KR+ S HP F+D++ Sbjct: 420 SKDFCEA--------------LLQKDPEKRLGFRDGSCDGLRTHPLFRDIS 456 >4UY9-A nrPDB Length = 323 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 66/213 (30%), Positives = 99/213 (46%), Gaps = 24/213 (11%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPST---AIREISLLKELNHPNIV 64 E IG G +G VY+A G+ VA+K R D + E + T +E L L HPNI+ Sbjct: 15 EIIGIGGFGKVYRAF--WIGDEVAVKAARHDPD-EDISQTIENVRQEAKLFAMLKHPNII 71 Query: 65 KLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR- 122 L V E L LV EF L + + IP ++ ++ Q+ +G+ + H Sbjct: 72 ALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR---IPPDILVNWAVQIARGMNYLHDEAI 128 Query: 123 --VLHRDLKPQNLLI--------NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 ++HRDLK N+LI + +K+ DFGLAR + T T + APE Sbjct: 129 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH--RTTKMSAAGTYAWMAPE 186 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPG 205 ++ +S D+WS G + E++T F G Sbjct: 187 VIRA-SMFSKGSDVWSYGVLLWELLTGEVPFRG 218 >4K33-A nrPDB Length = 325 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 61/235 (25%), Positives = 112/235 (47%), Gaps = 31/235 (13%) Query: 10 IGEGTYGVVYKA------RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPN 62 +GEG +G V A +++ V K+ D T+ S + E+ ++K + H N Sbjct: 44 LGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 103 Query: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPL--------------IKSY 107 I+ LL LY++ E+ + +L++F+ A G+ + S Sbjct: 104 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLTFKDLVSC 163 Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT-- 165 +Q+ +G+ + S + +HRDL +N+L+ + +K+ADFGLAR V Y E Sbjct: 164 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLAR--DVHNLDYYKETTNGR 221 Query: 166 --LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFR 217 + + APE L + Y+ D+WS G + E+ T + +PG +++LF++ + Sbjct: 222 LPVKWMAPEALFD-RVYTHQSDVWSFGVLLWEIFTLGGSPYPG-IPVEELFKLLK 274 >1U59-A nrPDB Length = 287 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 58/198 (29%), Positives = 95/198 (47%), Gaps = 14/198 (7%) Query: 9 KIGEGTYGVV----YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64 ++G G +G V Y+ R K VA+K ++ TE +RE ++ +L++P IV Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEM-MREAQIMHQLDNPYIV 73 Query: 65 KLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 +L+ V E L LV E L KF+ IP+ + L Q+ G+ + Sbjct: 74 RLIGVCQAE-ALMLVMEMAGGGPLHKFL-VGKREEIPVSNVAELLHQVSMGMKYLEEKNF 131 Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILLGCKYY 180 +HRDL +N+L+ K++DFGL++A G YT W + APE + + + Sbjct: 132 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC-INFRKF 190 Query: 181 STAVDIWSLGCIFAEMVT 198 S+ D+WS G E ++ Sbjct: 191 SSRSDVWSYGVTMWEALS 208 >4OW8-A nrPDB Length = 283 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/210 (30%), Positives = 99/210 (47%), Gaps = 15/210 (7%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKL 66 I G G V++A + G VA+K ++ + ++ P R E LNHP I + Sbjct: 19 IATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSD--PEFIERFRAEARTTAMLNHPGIASV 76 Query: 67 LDVIHTE-----NKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 D ++ YLV E ++ + L + + + L L Q + L H+ Sbjct: 77 HDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHAL--DMLEQTGRALQIAHA 134 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGCKY 179 ++HRD+KP N+LI G +K+ DFG+A+A T T V+ T Y APE LG Sbjct: 135 AGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHD- 193 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209 S A D++SLG + E V+ + F GD + Sbjct: 194 ASPASDVYSLGVVGYEAVSGKRPFAGDGAL 223 >5AMN-A nrPDB Length = 299 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 101/206 (49%), Gaps = 20/206 (9%) Query: 10 IGEGTYGVVYKA-----RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64 +GEG +G V KA + + VA+K ++ + + + E ++LK++NHP+++ Sbjct: 31 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSEL-RDLLSEFNVLKQVNHPHVI 89 Query: 65 KLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIK--------SYLFQLLQGL 115 KL + L L+ E+ + L+ F+ S G P + S+ +Q+ QG+ Sbjct: 90 KLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQISQGM 149 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF---GVPVRTYTHEVVTLWYRAPE 172 + +++HRDL +N+L+ +K++DFGL+R V+ + W A E Sbjct: 150 QYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM-AIE 208 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVT 198 L Y+T D+WS G + E+VT Sbjct: 209 SLFD-HIYTTQSDVWSFGVLLWEIVT 233 >4YFF-A nrPDB Length = 311 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 70/274 (25%), Positives = 124/274 (45%), Gaps = 43/274 (15%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTE-TEGVPSTAIREISLLKELNHPNIVKL 66 E IG G++G VYK R + ++VA+K+ R +T ++ RE+S+L +LNHP +++ Sbjct: 48 EIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQF 105 Query: 67 LDVIHTENKLYLV----------FEFLHQDLKKFMDASALTGIPLPLIKS--YLFQLLQG 114 + + + + F LH+ K+ +D + I + + K YL L Q Sbjct: 106 VGACLNDPSQFAIVTQYISGGSLFSLLHEQ-KRILDLQSKLIIAVDVAKGMEYLHNLTQ- 163 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVVTLWYRAPEI 173 ++HRDL N+L+ +G +ADFG +R + T + L + APE+ Sbjct: 164 -------PIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEV 216 Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVTRRALF----PGDSEIDQLFRIFR-----TLGTP-D 223 C Y+ D++S E++T F P + D + R ++ P Sbjct: 217 FTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPIS 276 Query: 224 EVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDE 257 ++ G + P+ +P +FS+VV L+E Sbjct: 277 SLLIRGWNACPEGRP--------EFSEVVMKLEE 302 >3DTC-A nrPDB Length = 271 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 66/214 (30%), Positives = 100/214 (46%), Gaps = 26/214 (12%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPST---AIREISLLKELNHPNIV 64 E IG G +G VY+A G+ VA+K R D + E + T +E L L HPNI+ Sbjct: 13 EIIGIGGFGKVYRAF--WIGDEVAVKAARHDPD-EDISQTIENVRQEAKLFAMLKHPNII 69 Query: 65 KLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR- 122 L V E L LV EF L + + IP ++ ++ Q+ +G+ + H Sbjct: 70 ALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR---IPPDILVNWAVQIARGMNYLHDEAI 126 Query: 123 --VLHRDLKPQNLLI--------NTEGAIKLADFGLARAFGVPVRTYTHEVVTLW-YRAP 171 ++HRDLK N+LI + +K+ DFGLAR + RT + + AP Sbjct: 127 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH---RTTKMSAAGAYAWMAP 183 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPG 205 E++ +S D+WS G + E++T F G Sbjct: 184 EVIRA-SMFSKGSDVWSYGVLLWELLTGEVPFRG 216 >4X3F-A nrPDB Length = 337 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/210 (30%), Positives = 99/210 (47%), Gaps = 15/210 (7%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKL 66 I G G V++A + G VA+K ++ + ++ P R E LNHP I + Sbjct: 20 IATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSD--PEFIERFRAEARTTAMLNHPGIASV 77 Query: 67 LDVIHTE-----NKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 D ++ YLV E ++ + L + + + L L Q + L H+ Sbjct: 78 HDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHAL--DMLEQTGRALQIAHA 135 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGCKY 179 ++HRD+KP N+LI G +K+ DFG+A+A T T V+ T Y APE LG Sbjct: 136 AGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHD- 194 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209 S A D++SLG + E V+ + F GD + Sbjct: 195 ASPASDVYSLGVVGYEAVSGKRPFAGDGAL 224 >4HVI-A nrPDB Length = 314 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/214 (29%), Positives = 101/214 (47%), Gaps = 30/214 (14%) Query: 3 NFQKVEKIGEGTYGVV----YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL 58 + + + ++G+G +G V Y TG +VA+K+++ + REI +LK L Sbjct: 11 HLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ--QRDFQREIQILKAL 68 Query: 59 NHPNIVKLLDVIHTENK--LYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYL 108 + IVK V + + L LV E+L Q + +DAS L Y Sbjct: 69 HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLL--------LYS 120 Query: 109 FQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT----HEVV 164 Q+ +G+ + S R +HRDL +N+L+ +E +K+ADFGLA+ + Y + Sbjct: 121 SQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSP 180 Query: 165 TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 WY APE L +S D+WS G + E+ T Sbjct: 181 IFWY-APESLSD-NIFSRQSDVWSFGVVLYELFT 212 >6B2Q-A nrPDB Length = 317 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/210 (30%), Positives = 99/210 (47%), Gaps = 15/210 (7%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKL 66 I G G V++A + G VA+K ++ + ++ P R E LNHP I + Sbjct: 40 IATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSD--PEFIERFRAEARTTAMLNHPGIASV 97 Query: 67 LDVIHTE-----NKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 D ++ YLV E ++ + L + + + L L Q + L H+ Sbjct: 98 HDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHAL--DMLEQTGRALQIAHA 155 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGCKY 179 ++HRD+KP N+LI G +K+ DFG+A+A T T V+ T Y APE LG Sbjct: 156 AGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHD- 214 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209 S A D++SLG + E V+ + F GD + Sbjct: 215 ASPASDVYSLGVVGYEAVSGKRPFAGDGAL 244 >5X5O-A nrPDB Length = 310 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 103/208 (49%), Gaps = 17/208 (8%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++ Q E G G++G VY+A+ + VA+KK+ L E +E +L L+H Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIE---------KEAEILSVLSHR 64 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NI++ VI +V E+ L +++++ + + I ++ + +G+ + H Sbjct: 65 NIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHM 124 Query: 121 H---RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 +V+HRDLK +N++I +G +K+ DFG +R T+ V T + APE++ Sbjct: 125 EAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHT--THMSLVGTFPWMAPEVIQSL 182 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPG 205 T D +S G + EM+TR F G Sbjct: 183 PVSETC-DTYSYGVVLWEMLTREVPFKG 209 >2R2P-A nrPDB Length = 295 Score = 75.5 bits (184), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 56/196 (28%), Positives = 99/196 (50%), Gaps = 10/196 (5%) Query: 10 IGEGTYGVVYKARNKLTGEV---VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 IG G +G V R KL G+ VA+K +++ TE + E S++ + +HPNI+ L Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY-TEKQRRDFLGEASIMGQFDHPNIIHL 88 Query: 67 LDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 125 V+ + +V E++ L F+ + + L+ L + G+ + +H Sbjct: 89 EGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLV-GMLRGISAGMKYLSDMGYVH 147 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHE--VVTLWYRAPEILLGCKYYST 182 RDL +N+LIN+ K++DFGL+R P YT + + + APE + + +++ Sbjct: 148 RDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPE-AIAFRKFTS 206 Query: 183 AVDIWSLGCIFAEMVT 198 A D+WS G + E+V+ Sbjct: 207 ASDVWSYGIVMWEVVS 222 >6J5U-C nrPDB Length = 426 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 112/219 (51%), Gaps = 24/219 (10%) Query: 2 ENFQKVEKIGEGTYGVVYK---------ARNKLTGEVVALKKIRLDTETEGVPSTA--IR 50 +NF++ +GEG +G V+K A +G VVA+K+++ EG + Sbjct: 84 KNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLK----PEGFQGHKEWLT 139 Query: 51 EISLLKELNHPNIVKLLD-VIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYL 108 E++ L +L+HPN+V L+ EN+L LV+EF+ + L+ + + + Sbjct: 140 EVNYLGQLSHPNLVLLVGYCAEGENRL-LVYEFMPKGSLENHLFRRGAQPLTWAIRMKVA 198 Query: 109 FQLLQGLAFCHSHR--VLHRDLKPQNLLINTEGAIKLADFGLARA--FGVPVRTYTHEVV 164 +GL F H + V++RD K N+L++ + KL+DFGLA+A G T + Sbjct: 199 VGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIG 258 Query: 165 TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL 202 T Y APE + + + + D++S G + E+++ RRA+ Sbjct: 259 THGYAAPEYVATGRLTAKS-DVYSFGVVLLELISGRRAM 296 >3DKO-A nrPDB Length = 318 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 102/201 (50%), Gaps = 11/201 (5%) Query: 6 KVEK-IGEGTYGVVYKARNKLTGE---VVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 K+E+ IG G +G V R KL G+ VA+K +++ TE + E S++ + +HP Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY-TEKQRRDFLCEASIMGQFDHP 104 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 N+V L V+ + +V EF+ L F+ + L+ L + G+ + Sbjct: 105 NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLV-GMLRGIAAGMRYLAD 163 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFG---VPVRTYTHEVVTLWYRAPEILLGC 177 +HRDL +N+L+N+ K++DFGL+R V T T + + + APE + Sbjct: 164 MGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQ-Y 222 Query: 178 KYYSTAVDIWSLGCIFAEMVT 198 + +++A D+WS G + E+++ Sbjct: 223 RKFTSASDVWSYGIVMWEVMS 243 >3QGY-A nrPDB Length = 286 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 59/204 (28%), Positives = 101/204 (49%), Gaps = 26/204 (12%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 V++IG G +G+V+ L + VA+K I+ + +E I E ++ +L+HP +V+L Sbjct: 32 VQEIGSGQFGLVHLGY-WLNKDKVAIKTIKEGSMSE---DDFIEEAEVMMKLSHPKLVQL 87 Query: 67 LDVIHTENKLYLVFEFL-HQDLKKFM-------DASALTGIPLPLIKSYLFQLLQGLAFC 118 V + + LVFEF+ H L ++ A L G+ L + +G+A+ Sbjct: 88 YGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCL--------DVCEGMAYL 139 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILL 175 V+HRDL +N L+ IK++DFG+ R V YT T + + +PE+ Sbjct: 140 EEACVIHRDLAARNCLVGENQVIKVSDFGMTRF--VLDDQYTSSTGTKFPVKWASPEVFS 197 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTR 199 + YS+ D+WS G + E+ + Sbjct: 198 FSR-YSSKSDVWSFGVLMWEVFSE 220 >2HW6-A nrPDB Length = 307 Score = 75.1 bits (183), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 78/309 (25%), Positives = 127/309 (41%), Gaps = 56/309 (18%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NHPNIVKL 66 E +GEG Y V A + G+ A+K I + + S RE+ L + + NI++L Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQCQGNKNILEL 76 Query: 67 LDVIHTENKLYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 ++ + + YLVFE L Q K F + A + + L F Sbjct: 77 IEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREA---------SRVVRDVAAALDFL 127 Query: 119 HSHRVLHRDLKPQNLLINTE---GAIKLADFGLARAFGV-----PVRT--YTHEVVTLWY 168 H+ + HRDLKP+N+L + +K+ DF L + P+ T T + Y Sbjct: 128 HTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEY 187 Query: 169 RAPEILL----GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEID------QLFRIFRT 218 APE++ +Y D+WSLG + M++ F G D ++ R+ + Sbjct: 188 MAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQN 247 Query: 219 LGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAK 278 E + G PD WA + + + L+S++L D +R+SA Sbjct: 248 --KLFESIQEGKYEFPD-----KDWAH---------ISSEAKDLISKLLVRDAKQRLSAA 291 Query: 279 AALAHPFFQ 287 L HP+ Q Sbjct: 292 QVLQHPWVQ 300 >4C59-A nrPDB Length = 340 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 63/223 (28%), Positives = 100/223 (44%), Gaps = 34/223 (15%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVKLLD 68 + EG + VY+A++ +G ALK RL + E I+E+ +K+L+ HPNIV+ Sbjct: 35 LAEGGFAFVYEAQDVGSGREYALK--RLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCS 92 Query: 69 VIHT--------ENKLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCH 119 + + L+ E L +F+ G + + +Q + + H Sbjct: 93 AASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMH 152 Query: 120 SHR--VLHRDLKPQNLLINTEGAIKLADFGLAR--------AFGVPVRTYTHEVVTL--- 166 + ++HRDLK +NLL++ +G IKL DFG A ++ R E +T Sbjct: 153 RQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTT 212 Query: 167 -WYRAPEILLGCKYYST-----AVDIWSLGCIFAEMVTRRALF 203 YR PEI+ YS DIW+LGCI + R+ F Sbjct: 213 PMYRTPEII---DLYSNFPIGEKQDIWALGCILYLLCFRQHPF 252 >6BDL-A nrPDB Length = 347 Score = 74.7 bits (182), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 62/219 (28%), Positives = 103/219 (47%), Gaps = 29/219 (13%) Query: 1 MENFQKVEKIGEGTYG----VVYKARNKLTGEVVALKKIRL-DTETEGVPSTAIREISLL 55 + +F ++ +G G +G V K+ T + LKK + DT + IR + Sbjct: 33 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQ----EHIRSEKQI 88 Query: 56 KELNHPN-IVKLLDVIHTENKLYLVFEF--------LHQDLKKFMDASALTGIPLPLIKS 106 + H + IV+L LY++ E + +D F D++ + Sbjct: 89 MQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTT---------RF 139 Query: 107 YLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTL 166 Y +++ A+ HS +++RDLKP+NL+++ G KL DFG A+ G +T+T T Sbjct: 140 YTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTF-CGTP 198 Query: 167 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPG 205 Y APEI+L K + + D WSLG + E++T F G Sbjct: 199 EYVAPEIILN-KGHDISADYWSLGILMYELLTGSPPFSG 236 >2OZO-A nrPDB Length = 613 Score = 74.7 bits (182), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 57/198 (28%), Positives = 95/198 (47%), Gaps = 14/198 (7%) Query: 9 KIGEGTYGVV----YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64 ++G G +G V Y+ R K VA+K ++ TE +RE ++ +L++P IV Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADT-EEMMREAQIMHQLDNPYIV 399 Query: 65 KLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 +L+ V E L LV E L KF+ IP+ + L Q+ G+ + Sbjct: 400 RLIGVCQAE-ALMLVMEMAGGGPLHKFL-VGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILLGCKYY 180 +HR+L +N+L+ K++DFGL++A G YT W + APE + + + Sbjct: 458 VHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC-INFRKF 516 Query: 181 STAVDIWSLGCIFAEMVT 198 S+ D+WS G E ++ Sbjct: 517 SSRSDVWSYGVTMWEALS 534 >3C1X-A nrPDB Length = 373 Score = 74.7 bits (182), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 101/203 (49%), Gaps = 12/203 (5%) Query: 8 EKIGEGTYGVVYKAR---NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64 E IG G +G VY N A+K + T+ G S + E ++K+ +HPN++ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDI-GEVSQFLTEGIIMKDFSHPNVL 153 Query: 65 KLLDV-IHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 LL + + +E +V ++ H DL+ F+ LI + Q+ +G+ F S + Sbjct: 154 SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLI-GFGLQVAKGMKFLASKK 212 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFG----VPVRTYTHEVVTLWYRAPEILLGCK 178 +HRDL +N +++ + +K+ADFGLAR V T + + + A E L K Sbjct: 213 FVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQK 272 Query: 179 YYSTAVDIWSLGCIFAEMVTRRA 201 ++T D+WS G + E++TR A Sbjct: 273 -FTTKSDVWSFGVLLWELMTRGA 294 >3V5Q-A nrPDB Length = 297 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 98/215 (45%), Gaps = 31/215 (14%) Query: 9 KIGEGTYGVVYKA--------RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++GEG +G V+ A ++K+ V ALK L + RE LL L H Sbjct: 22 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKD-----FQREAELLTNLQH 76 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASA------LTGIP--------LPLIK 105 +IVK V + L +VFE++ H DL KF+ A + G P L + Sbjct: 77 EHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQML 136 Query: 106 SYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYTHEV 163 Q+ G+ + S +HRDL +N L+ +K+ DFG++R R H + Sbjct: 137 HIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTM 196 Query: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 + + + PE ++ + ++T D+WS G I E+ T Sbjct: 197 LPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFT 230 >5HLW-A nrPDB Length = 299 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 59/203 (29%), Positives = 101/203 (49%), Gaps = 12/203 (5%) Query: 8 EKIGEGTYGVVYKAR---NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64 E IG G +G VY N A+K + T+ G S + E ++K+ +HPN++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDI-GEVSQFLTEGIIMKDFSHPNVL 84 Query: 65 KLLDV-IHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 LL + + +E +V ++ H DL+ F+ LI + Q+ +G+ + S + Sbjct: 85 SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLI-GFGLQVAKGMKYLASKK 143 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFG----VPVRTYTHEVVTLWYRAPEILLGCK 178 +HRDL +N +++ + +K+ADFGLAR V T + + + A E L K Sbjct: 144 FVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQK 203 Query: 179 YYSTAVDIWSLGCIFAEMVTRRA 201 ++T D+WS G + E++TR A Sbjct: 204 -FTTKSDVWSFGVLLWELMTRGA 225 >4X7Q-B nrPDB Length = 312 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 67/226 (29%), Positives = 105/226 (46%), Gaps = 17/226 (7%) Query: 10 IGEGTYGVVYKARNKLTGEV-VALKKIRLDTETEGVP----STAIREISLLKELN----H 60 +G+G +G V+ A ++LT + VA+K I + P T E++LL ++ H Sbjct: 39 LGKGGFGTVF-AGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGH 97 Query: 61 PNIVKLLDVIHTENKLYLVFE--FLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 P +++LLD T+ LV E QDL ++ G + + Q++ + C Sbjct: 98 PGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLG--EGPSRCFFGQVVAAIQHC 155 Query: 119 HSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 HS V+HRD+K +N+LI+ G KL DFG YT T Y PE + Sbjct: 156 HSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLH--DEPYTDFDGTRVYSPPEWISRH 213 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD 223 +Y++ +WSLG + +MV F D EI + F +PD Sbjct: 214 QYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPD 259 >2VD5-A nrPDB Length = 412 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 82/299 (27%), Positives = 124/299 (41%), Gaps = 42/299 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNH 60 ++F+ ++ IG G + V + K TG+V A+K + + D G S E +L + Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 61 PNIVKLLDVIHTENKLYLVFEF-LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 I +L EN LYLV E+ + DL + IP + + YL +++ + H Sbjct: 121 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFG-ERIPAEMARFYLAEIVMAIDSVH 179 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLA---RAFGVPVRTYTHEVVTLWYRAPEILLG 176 +HRD+KP N+L++ G I+LADFG RA G VR+ V T Y +PEIL Sbjct: 180 RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGT-VRSLV-AVGTPDYLSPEILQA 237 Query: 177 CKYYSTA------VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 D W+LG EM + F DS + +I V + Sbjct: 238 VGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI---------VHYKEH 288 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA---LAHPFF 286 S+P P+ AR +++ P P R+ A HPFF Sbjct: 289 LSLPLVDEGVPEEARDFIQRLLCP----------------PETRLGRGGAGDFRTHPFF 331 >4M66-A nrPDB Length = 325 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 75/260 (28%), Positives = 124/260 (47%), Gaps = 41/260 (15%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELNH 60 E +K+E +G+G +GVV++A ++ VA+K + S I E+ + L + Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN---------SKKISWEVKAMVNLRN 70 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQD--LKKFMDASALTGI-------PLPLIKSYLFQL 111 N++ LL V TE+ L ++F+ + +FM+ +L G+ P PL+ L ++ Sbjct: 71 ENVLLLLGV--TED---LQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEV 125 Query: 112 LQGLAFCHSHR--VLHRDLKPQNLLINTEGAIKLADFGLA------RAFGVPVRTYTHEV 163 + G+ + HS +LHRDLKP N+L++ E KLADFGL+ ++ Sbjct: 126 VLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSG 185 Query: 164 VTLWYRAPEILLGCKY-YSTAVDIWSLGC-IFAEMVTRRALFPGDSEIDQLFRIFRTLGT 221 TL Y PE+L S A D++S G ++A + R A +D+ I T+ Sbjct: 186 GTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAEL-----VDKTSLIRETVC- 239 Query: 222 PDEVVWPGVTSMPDYKPSFP 241 D P +T +P P P Sbjct: 240 -DRQSRPPLTELPPGSPETP 258 >4NEU-A nrPDB Length = 333 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 63/250 (25%), Positives = 112/250 (44%), Gaps = 42/250 (16%) Query: 49 IREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSY 107 + E ++ L H +VKLL VI E K LV E++ + +L + A T PL + Sbjct: 70 LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMST--PLSVKGRI 127 Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE----- 162 + ++++G+ + H V+H+DLKP+N+L++ + IK+AD GLA +F + + E Sbjct: 128 ILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLA-SFKMWSKLNNEEHNELR 186 Query: 163 ---------VVTLWYRAPEILLGCKYYSTA-VDIWSLGCIFAEMVTRRALFPGDSEIDQL 212 TL+Y APE L T D++S + + + + QL Sbjct: 187 EVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQL 246 Query: 213 FRIFRTLGTPD----------------EVVWPGVTSMPDYKPSFP----KWARQDFSKVV 252 ++ PD ++ W + P+ +P+FP K+ S++ Sbjct: 247 IMCIKSGNRPDVDDITEYCPREIISLMKLCW---EANPEARPTFPGIEEKFRPFYLSQLE 303 Query: 253 PPLDEDGRSL 262 ++ED +SL Sbjct: 304 ESVEEDVKSL 313 >5L6P-A nrPDB Length = 298 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 101/200 (50%), Gaps = 12/200 (6%) Query: 8 EKIGEGTYGVVYKARNKLTGE---VVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64 E IG G +G V + R K G VA+K +++ TE + E S++ + +HPNI+ Sbjct: 25 EVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGY-TERQRRDFLSEASIMGQFDHPNII 83 Query: 65 KLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 +L V+ + ++ EF+ L F+ + + L+ L + G+ + Sbjct: 84 RLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLV-GMLRGIAAGMKYLSEMNY 142 Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR--TYTHEV---VTLWYRAPEILLGCK 178 +HRDL +N+L+N+ K++DFGL+R TYT + + + + APE + + Sbjct: 143 VHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEA-IAYR 201 Query: 179 YYSTAVDIWSLGCIFAEMVT 198 +++A D+WS G + E+++ Sbjct: 202 KFTSASDVWSYGIVMWEVMS 221 >2OU7-A nrPDB Length = 335 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 66/238 (27%), Positives = 101/238 (42%), Gaps = 35/238 (14%) Query: 51 EISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQD--LKKFMDASALTGIPLPLIKSYL 108 EIS+ + L H ++V + +++V E + L+ ALT P + YL Sbjct: 91 EISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTE---PEARYYL 147 Query: 109 FQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWY 168 Q++ G + H +RV+HRDLK NL +N + +K+ DFGLA T Y Sbjct: 148 RQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNY 207 Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228 APE+ L K +S VD+WS+GCI ++ + F + RI + Sbjct: 208 IAPEV-LSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKN---------- 256 Query: 229 GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 +Y S PK ++ SL+ +ML DP R + L FF Sbjct: 257 ------EY--SIPKH-----------INPVAASLIQKMLQTDPTARPTINELLNDEFF 295 >1FVR-A nrPDB Length = 327 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 74/276 (26%), Positives = 118/276 (42%), Gaps = 51/276 (18%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR--------EISLL 55 FQ V IGEG +G V KAR K G +R+D + + A + E+ +L Sbjct: 29 FQDV--IGEGNFGQVLKARIKKDG-------LRMDAAIKRMKEYASKDDHRDFAGELEVL 79 Query: 56 KEL-NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDAS---------ALTGIPLPLI 104 +L +HPNI+ LL LYL E+ H +L F+ S A+ + Sbjct: 80 CKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTL 139 Query: 105 KS-----YLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY 159 S + + +G+ + + +HRDL +N+L+ K+ADFGL+R V V+ Sbjct: 140 SSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKT 199 Query: 160 THEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRAL-FPGDS------EIDQL 212 + W L Y+T D+WS G + E+V+ + G + ++ Q Sbjct: 200 MGRLPVRWMAIES--LNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQG 257 Query: 213 FRIFRTLGTPDEV------VWPGVTSMPDYKPSFPK 242 +R+ + L DEV W P +PSF + Sbjct: 258 YRLEKPLNCDDEVYDLMRQCW---REKPYERPSFAQ 290 >4XLV-A nrPDB Length = 328 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 51/212 (24%), Positives = 106/212 (50%), Gaps = 16/212 (7%) Query: 2 ENFQKVEKIGEGTYGVVYK--ARNKLTGEVVALKKIRLDTETEGVPSTA--IREISLLKE 57 E + ++G+G++G+VY+ AR+ + GE ++ E+ + + E S++K Sbjct: 39 EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKG 98 Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFM-----DASALTGIPLPLIKSYL--- 108 ++V+LL V+ +V E + H DLK ++ +A G P P ++ + Sbjct: 99 FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA 158 Query: 109 FQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYTHEVVTL 166 ++ G+A+ ++ + +HRDL +N ++ + +K+ DFG+ R R ++ + Sbjct: 159 AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV 218 Query: 167 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 + APE L ++T+ D+WS G + E+ + Sbjct: 219 RWMAPESLKD-GVFTTSSDMWSFGVVLWEITS 249 >4PDO-A nrPDB Length = 299 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 60/202 (29%), Positives = 103/202 (50%), Gaps = 13/202 (6%) Query: 5 QKVEKIGEGTYGVVYKARNKLTG---EV-VALKKIRLDTETEGVPSTAIREISLLKELNH 60 QKV IG G +G VYK K + EV VA+K ++ TE + E ++ + +H Sbjct: 39 QKV--IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGY-TEKQRVDFLGEAGIMGQFSH 95 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 NI++L VI + ++ E++ L KF+ L L+ L + G+ + Sbjct: 96 HNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLV-GMLRGIAAGMKYLA 154 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHE--VVTLWYRAPEILLG 176 + +HRDL +N+L+N+ K++DFGL+R P TYT + + + APE + Sbjct: 155 NMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPE-AIS 213 Query: 177 CKYYSTAVDIWSLGCIFAEMVT 198 + +++A D+WS G + E++T Sbjct: 214 YRKFTSASDVWSFGIVMWEVMT 235 >4J52-A nrPDB Length = 293 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 66/238 (27%), Positives = 101/238 (42%), Gaps = 35/238 (14%) Query: 51 EISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQD--LKKFMDASALTGIPLPLIKSYL 108 EIS+ + L H ++V + +++V E + L+ ALT P + YL Sbjct: 64 EISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTE---PEARYYL 120 Query: 109 FQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWY 168 Q++ G + H +RV+HRDLK NL +N + +K+ DFGLA T Y Sbjct: 121 RQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNY 180 Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228 APE+ L K +S VD+WS+GCI ++ + F + RI + Sbjct: 181 IAPEV-LSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKN---------- 229 Query: 229 GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 +Y S PK ++ SL+ +ML DP R + L FF Sbjct: 230 ------EY--SIPKH-----------INPVAASLIQKMLQTDPTARPTINELLNDEFF 268 >1BYG-A nrPDB Length = 278 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 101/200 (50%), Gaps = 12/200 (6%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 M+ + ++ IG+G +G V + G VA+K I+ D + + E S++ +L H Sbjct: 20 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF----LAEASVMTQLRH 73 Query: 61 PNIVKLLDVIHTE-NKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 N+V+LL VI E LY+V E++ + L ++ + + + + + + + + + Sbjct: 74 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 133 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 + +HRDL +N+L++ + K++DFGL + T + + + APE L K Sbjct: 134 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE---ASSTQDTGKLPVKWTAPEALRE-K 189 Query: 179 YYSTAVDIWSLGCIFAEMVT 198 +ST D+WS G + E+ + Sbjct: 190 KFSTKSDVWSFGILLWEIYS 209 >5KMM-A nrPDB Length = 329 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/214 (28%), Positives = 98/214 (45%), Gaps = 30/214 (14%) Query: 9 KIGEGTYGVVYKA--------RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++GEG +G V+ A ++K+ V ALK+ +E RE LL L H Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA-----SESARQDFQREAELLTMLQH 96 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFM-----DASALTG----IPLPLIKSYLF- 109 +IV+ V L +VFE++ H DL +F+ DA L G P PL L Sbjct: 97 QHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLA 156 Query: 110 ---QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYTHEVV 164 Q+ G+ + +HRDL +N L+ +K+ DFG++R R ++ Sbjct: 157 VASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML 216 Query: 165 TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 + + PE +L + ++T D+WS G + E+ T Sbjct: 217 PIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFT 249 >5IKW-A nrPDB Length = 310 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/209 (30%), Positives = 102/209 (48%), Gaps = 22/209 (10%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVKL 66 E + EG + V+ R G ALK++ ++ + + REI+++KEL+ H NIV Sbjct: 20 ESLAEGGFSTVFLVRTH-GGIRCALKRMYVNNMPD--LNVCKREITIMKELSGHKNIVGY 76 Query: 67 LDVIH---TEN--KLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 LD ++N ++ ++ E+ + M+ TG P + + +A H Sbjct: 77 LDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQ 136 Query: 121 HR--VLHRDLKPQNLLINTEGAIKLADFGLA-RAFGVP----VRTYTHEV---VTLWYRA 170 + ++HRDLK +N+L+N G L DFG A F P V E+ TL YRA Sbjct: 137 CKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRA 196 Query: 171 PEI--LLGCKYYSTAVDIWSLGCIFAEMV 197 PE+ L G K +T DIW+LGC+ ++ Sbjct: 197 PEMINLYGGKPITTKADIWALGCLLYKLC 225 >1K9A-A nrPDB Length = 450 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 101/200 (50%), Gaps = 12/200 (6%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 M+ + ++ IG+G +G V + G VA+K I+ D + + E S++ +L H Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF----LAEASVMTQLRH 245 Query: 61 PNIVKLLDVIHTE-NKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 N+V+LL VI E LY+V E++ + L ++ + + + + + + + + + Sbjct: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 + +HRDL +N+L++ + K++DFGL + T + + + APE L K Sbjct: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE---ASSTQDTGKLPVKWTAPEALRE-K 361 Query: 179 YYSTAVDIWSLGCIFAEMVT 198 +ST D+WS G + E+ + Sbjct: 362 KFSTKSDVWSFGILLWEIYS 381 >1JPA-A nrPDB Length = 312 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 102/203 (50%), Gaps = 13/203 (6%) Query: 6 KVEK-IGEGTYGVVYKARNKLTGE---VVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 K+E+ IG G +G V KL G+ VA+K ++ TE + E S++ + +HP Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLK-SGYTEKQRRDFLSEASIMGQFDHP 94 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 N++ L V+ + ++ EF+ L F+ + + L+ L + G+ + Sbjct: 95 NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLV-GMLRGIAAGMKYLAD 153 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR--TYTHEV---VTLWYRAPEILL 175 +HRDL +N+L+N+ K++DFGL+R TYT + + + + APE + Sbjct: 154 MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPE-AI 212 Query: 176 GCKYYSTAVDIWSLGCIFAEMVT 198 + +++A D+WS G + E+++ Sbjct: 213 QYRKFTSASDVWSYGIVMWEVMS 235 >3BBT-B nrPDB Length = 328 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 102/202 (50%), Gaps = 11/202 (5%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALK-KIRLDTETEGVPSTA--IREISLLKELNH 60 ++V+ +G G +G VYK GE V + I++ ET G + + E ++ ++H Sbjct: 17 LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH 76 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 P++V+LL V + + LV + + H L +++ I L+ ++ Q+ +G+ + Sbjct: 77 PHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHK-DNIGSQLLLNWCVQIAKGMMYLE 134 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 R++HRDL +N+L+ + +K+ DFGLAR + Y + + + + L C + Sbjct: 135 ERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKW--MALECIH 192 Query: 180 Y---STAVDIWSLGCIFAEMVT 198 Y + D+WS G E++T Sbjct: 193 YRKFTHQSDVWSYGVTIWELMT 214 >4P5Q-A nrPDB Length = 361 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 52/196 (26%), Positives = 98/196 (50%), Gaps = 10/196 (5%) Query: 10 IGEGTYGVVYKARNKLTGE---VVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 +G G +G V R KL + VA+K +++ TE + E S++ + +HPNI++L Sbjct: 41 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-TEKQRRDFLGEASIMGQFDHPNIIRL 99 Query: 67 LDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 125 V+ + +V E++ L F+ + L+ L + G+ + +H Sbjct: 100 EGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLV-GMLRGIASGMKYLSDMGYVH 158 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHE--VVTLWYRAPEILLGCKYYST 182 RDL +N+LIN+ K++DFGL+R P YT + + + +PE + + +++ Sbjct: 159 RDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPE-AIAYRKFTS 217 Query: 183 AVDIWSLGCIFAEMVT 198 A D+WS G + E+++ Sbjct: 218 ASDVWSYGIVLWEVMS 233 >6BXI-A nrPDB Length = 333 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 65/235 (27%), Positives = 100/235 (42%), Gaps = 42/235 (17%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELN 59 +E+F+ ++ IG G +G V + K TG V A+K +R E IR E +L E + Sbjct: 5 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 64 Query: 60 HPNIVKLLDVIHTENKLYLVFEFL--HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 +VK+ + LYL+ EFL + M LT Y+ + + + Sbjct: 65 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQF---YIAETVLAIDS 121 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT-------------YTHEVV 164 H +HRD+KP NLL++++G +KL+DFGL RT +T + + Sbjct: 122 IHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNM 181 Query: 165 T------LWYR----------------APEILLGCKYYSTAVDIWSLGCIFAEMV 197 W R APE+ + Y+ D WSLG I EM+ Sbjct: 182 NSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-YNKLCDWWSLGVIMYEML 235 >5GNK-A nrPDB Length = 297 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 99/207 (47%), Gaps = 19/207 (9%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVV----ALKKIRLDTETEGVPSTAIREISLLKEL 58 F+K++ +G G +G VYK GE V A+K++R T + + E ++ + Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA-NKEILDEAYVMASV 78 Query: 59 NHPNIVKLLDVIHTENKLYLV----FEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 ++P++ +LL + T ++ F L +++ D I + ++ Q+ +G Sbjct: 79 DNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKD-----NIGSQYLLNWCVQIAKG 133 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE---VVTLWYRAP 171 + + R++HRDL +N+L+ T +K+ DFGLA+ G + Y E V W Sbjct: 134 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE 193 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVT 198 IL + Y+ D+WS G E++T Sbjct: 194 SILH--RIYTHQSDVWSYGVTVWELMT 218 >3LZB-A nrPDB Length = 327 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 98/207 (47%), Gaps = 19/207 (9%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVV----ALKKIRLDTETEGVPSTAIREISLLKEL 58 F+K++ +G G +G VYK GE V A+K++R T + + E ++ + Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA-NKEILDEAYVMASV 74 Query: 59 NHPNIVKLLDVIHTENKLYLV----FEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 ++P++ +LL + T + F L +++ D I + ++ Q+ +G Sbjct: 75 DNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKD-----NIGSQYLLNWCVQIAKG 129 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE---VVTLWYRAP 171 + + R++HRDL +N+L+ T +K+ DFGLA+ G + Y E V W Sbjct: 130 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE 189 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVT 198 IL + Y+ D+WS G E++T Sbjct: 190 SILH--RIYTHQSDVWSYGVTVWELMT 214 >4XI2-A nrPDB Length = 446 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 102/200 (51%), Gaps = 20/200 (10%) Query: 7 VEKIGEGTYGVVYKARNKLTGEV-VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVK 65 ++++G G +GVV K G+ VA+K IR + +E I E ++ L+H +V+ Sbjct: 192 LKELGTGQFGVV--KYGKWRGQYDVAIKMIREGSMSE---DEFIEEAKVMMNLSHEKLVQ 246 Query: 66 LLDVIHTENKLYLVFEFLHQ----DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 L V + ++++ E++ + + M T L + K + + + + S Sbjct: 247 LYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD----VCEAMEYLESK 302 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILLGCK 178 + LHRDL +N L+N +G +K++DFGL+R V YT V + + + PE+L+ K Sbjct: 303 QFLHRDLAARNCLVNDQGVVKVSDFGLSRY--VLDDEYTSSVGSKFPVRWSPPEVLMYSK 360 Query: 179 YYSTAVDIWSLGCIFAEMVT 198 +S+ DIW+ G + E+ + Sbjct: 361 -FSSKSDIWAFGVLMWEIYS 379 >3TKU-A nrPDB Length = 433 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 99/227 (43%), Gaps = 16/227 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIRE-ISLLKELNH 60 E+F+ ++ IG G +G V + K T + A+K + + + RE +L + Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 61 PNIVKLLDVIHTENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 I L EN LYLV ++ L L KF D +P + + Y+ +++ + Sbjct: 150 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDK-----LPEDMARFYIGEMVLAI 204 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEIL 174 H +HRD+KP N+L++ G I+LADFG + V T Y +PEIL Sbjct: 205 DSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEIL 264 Query: 175 L----GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR 217 G Y D WSLG EM+ F +S ++ +I Sbjct: 265 QAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN 311 >2Y6O-A nrPDB Length = 291 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 53/201 (26%), Positives = 102/201 (50%), Gaps = 11/201 (5%) Query: 6 KVEK-IGEGTYGVVYKARNKLTGE---VVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 K+EK IG G +G V R K+ G+ VA+K ++ T+ + E S++ + +HP Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGY-TDKQRRDFLSEASIMGQFDHP 75 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NI+ L V+ + ++ E++ L F+ + + L+ L + G+ + Sbjct: 76 NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLV-GMLRGIGSGMKYLSD 134 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHE--VVTLWYRAPEILLGC 177 +HRDL +N+L+N+ K++DFG++R P YT + + + APE + Sbjct: 135 MSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPE-AIAY 193 Query: 178 KYYSTAVDIWSLGCIFAEMVT 198 + +++A D+WS G + E+++ Sbjct: 194 RKFTSASDVWSYGIVMWEVMS 214 >5O0Y-A nrPDB Length = 579 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 82/305 (26%), Positives = 128/305 (41%), Gaps = 53/305 (17%) Query: 15 YGVVYKARNKLTGEVVALKKIRL-----DTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 + VYKA + VA+K +L D + E A RE + KEL+HP IVKL D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 70 IHTENKLYL-VFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR--VLH 125 + + V E+ DL ++ L + +S + Q++ L + + + ++H Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKL--MSEKEARSIIMQIVNALKYLNEIKPPIIH 414 Query: 126 RDLKPQN-LLINTE--GAIKLADFGLARAFGVP-------VRTYTHEVVTLWYRAPEILL 175 DLKP N LL+N G IK+ DFGL++ + + T WY PE + Sbjct: 415 YDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFV 474 Query: 176 GCK---YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 K S VD+WS+G IF + + R F G ++ Q T+ EV +P Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQDILQENTILKATEVQFPP--- 530 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 KP VV P + ++ + + L Y RI + P+ Sbjct: 531 ----KP------------VVTP---EAKAFIRRCLAYRKEDRIDVQQLACDPYL------ 565 Query: 293 VPHLR 297 +PH+R Sbjct: 566 LPHIR 570 >6CKI-A nrPDB Length = 316 Score = 70.9 bits (172), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 84/312 (26%), Positives = 133/312 (42%), Gaps = 48/312 (15%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVKLLD 68 +GEG + V N +T + A+K I + + + S RE+ +L + H N+++L++ Sbjct: 21 LGEGAHARVQTCINLITSQEYAVKII--EKQPGHIRSRVFREVEMLYQCQGHRNVLELIE 78 Query: 69 VIHTENKLYLVFEFLHQDLKKFMDASALTGIPL-----PLIKSYLFQ-LLQGLAFCHSHR 122 E++ YLVFE K S L+ I L S + Q + L F H+ Sbjct: 79 FFEEEDRFYLVFE-------KMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKG 131 Query: 123 VLHRDLKPQNLLI---NTEGAIKLADFGLARAF---GVPVRTYTHEVVT----LWYRAPE 172 + HRDLKP+N+L N +K+ DFGL G T E++T Y APE Sbjct: 132 IAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPE 191 Query: 173 ILLG----CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228 ++ Y D+WSLG I +++ F G D + +++ Sbjct: 192 VVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLF- 250 Query: 229 GVTSMPDYKPSFP--KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 S+ + K FP WA + + L+S++L D +R+SA L HP+ Sbjct: 251 --ESIQEGKYEFPDKDWAH---------ISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 299 Query: 287 QDV----TKPVP 294 Q T P P Sbjct: 300 QGCAPENTLPTP 311 >5FM2-A nrPDB Length = 355 Score = 70.9 bits (172), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 55/220 (25%), Positives = 102/220 (46%), Gaps = 34/220 (15%) Query: 10 IGEGTYGVVYKA-----RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64 +GEG +G V KA + + VA+K ++ + + + E ++LK++NHP+++ Sbjct: 72 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSEL-RDLLSEFNVLKQVNHPHVI 130 Query: 65 KLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTG----------------------IPL 101 KL + L L+ E+ + L+ F+ S G + + Sbjct: 131 KLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTM 190 Query: 102 PLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF---GVPVRT 158 + S+ +Q+ QG+ + +++HRDL +N+L+ +K++DFGL+R V+ Sbjct: 191 GDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR 250 Query: 159 YTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 + W A E L Y+T D+WS G + E+VT Sbjct: 251 SQGRIPVKWM-AIESLFD-HIYTTQSDVWSFGVLLWEIVT 288 >5U6C-A nrPDB Length = 315 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 106/221 (47%), Gaps = 35/221 (15%) Query: 10 IGEGTYGVVYKARNKL---TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 +GEG +G V + K T VA+K ++LD ++ + E + +K+ +HPN+++L Sbjct: 44 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVMRL 103 Query: 67 LDVIHTEN-----KLYLVFEFL-HQDLKKFMDASAL-TG---IPLPLIKSYLFQLLQGLA 116 L V + K ++ F+ + DL ++ S L TG IPL + ++ + G+ Sbjct: 104 LGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGME 163 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL-- 174 + + LHRDL +N ++ + + +ADFGL++ + Y+ + +YR I Sbjct: 164 YLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSK------KIYSGD----YYRQGRIAKM 213 Query: 175 ---------LGCKYYSTAVDIWSLGCIFAEMVTRRAL-FPG 205 L + Y++ D+W+ G E+ TR +PG Sbjct: 214 PVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG 254 >4F9B-A nrPDB Length = 361 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 82/356 (23%), Positives = 141/356 (39%), Gaps = 80/356 (22%) Query: 1 MENFQKVE-KIGEGTYGVVYKARNKLT---GEVVALKKIRLDTETEGVPST-AIREISLL 55 + N K+E KIGEGT+ VY A +L E +ALK + +P++ IR + L Sbjct: 19 LSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHL--------IPTSHPIRIAAEL 70 Query: 56 KELN----HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQL 111 + L N++ + + + + +L + F+D L + ++ Y+ L Sbjct: 71 QCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHE--SFLDI--LNSLSFQEVREYMLNL 126 Query: 112 LQGLAFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAF--------------GVPV 156 + L H ++HRD+KP N L N L DFGLA+ Sbjct: 127 FKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQE 186 Query: 157 RTYTHEVV--------------TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRR-A 201 R ++ T +RAPE+L C +TA+D+WS G IF +++ R Sbjct: 187 RCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYP 246 Query: 202 LFPGDSEIDQLFRIFRTLGTPD----------EVVWPGVTSMPDYKPSFPKWARQDFSKV 251 + ++ L +I G+ + ++ D + + D S Sbjct: 247 FYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSS-- 304 Query: 252 VPPLDEDGRSLLSQMLHY-----------------DPNKRISAKAALAHPFFQDVT 290 P L D + + + + +P RI+A+ AL HPFF+D++ Sbjct: 305 TPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMS 360 >2VWV-A nrPDB Length = 302 Score = 70.5 bits (171), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 54/206 (26%), Positives = 103/206 (50%), Gaps = 13/206 (6%) Query: 3 NFQKVEK-IGEGTYGVVYKARNKLTGE---VVALKKIRLDTETEGVPSTAIREISLLKEL 58 ++ K+E+ IG G +G V + R K G+ VA+K ++ TE + E S++ + Sbjct: 16 SYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK-GGYTERQRREFLSEASIMGQF 74 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 HPNI++L V+ + ++ EF+ L F+ + + L+ L + G+ + Sbjct: 75 EHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLV-GMLRGIASGMRY 133 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF----GVPVRTYT-HEVVTLWYRAPE 172 +HRDL +N+L+N+ K++DFGL+R P T + + + + APE Sbjct: 134 LAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPE 193 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVT 198 + + +++A D WS G + E+++ Sbjct: 194 A-IAFRKFTSASDAWSYGIVMWEVMS 218 >4H1J-A nrPDB Length = 293 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 51/195 (26%), Positives = 100/195 (51%), Gaps = 11/195 (5%) Query: 10 IGEGTYGVVYKA---RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 +GEG +G VY+ +K VA+K + D + + E ++K L+HP+IVKL Sbjct: 32 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKL 90 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 + +I E ++ + + +L +++ + + L L+ Y Q+ + +A+ S +HR Sbjct: 91 IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLV-LYSLQICKAMAYLESINCVHR 149 Query: 127 DLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT---LWYRAPEILLGCKYYSTA 183 D+ +N+L+ + +KL DFGL+R + Y VT + + +PE + + ++TA Sbjct: 150 DIAVRNILVASPECVKLGDFGLSRY--IEDEDYYKASVTRLPIKWMSPES-INFRRFTTA 206 Query: 184 VDIWSLGCIFAEMVT 198 D+W E+++ Sbjct: 207 SDVWMFAVCMWEILS 221 >2PMN-X nrPDB Length = 348 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 58/255 (22%), Positives = 110/255 (43%), Gaps = 30/255 (11%) Query: 50 REISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQD-LKKF------MDASALTGIPLP 102 E+ ++ ++ + + +I +++Y+++E++ D + KF +D + IP+ Sbjct: 92 NELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFIPIQ 151 Query: 103 LIKSYLFQLLQGLAFCHSHR-VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTH 161 +IK + +L ++ H+ + + HRD+KP N+L++ G +KL+DFG + + + Sbjct: 152 VIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEY--MVDKKIKG 209 Query: 162 EVVTLWYRAPEILLGCKYYSTA-VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLG 220 T + PE Y+ A VDIWSLG M F + +LF RT Sbjct: 210 SRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNIRTKN 269 Query: 221 TP-----DEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI 275 + ++P +F DF K+ L +P +RI Sbjct: 270 IEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKL--------------FLRKNPAERI 315 Query: 276 SAKAALAHPFFQDVT 290 +++ AL H + D Sbjct: 316 TSEDALKHEWLADTN 330 >3KA0-A nrPDB Length = 320 Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 75/298 (25%), Positives = 129/298 (43%), Gaps = 53/298 (17%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISL-LKELNHPNIVKLLD 68 +G G G V + NK T E ALK + + P A RE+ L + P+IV+++D Sbjct: 24 LGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRASQCPHIVRIVD 76 Query: 69 VIHT----ENKLYLVFEFLH-----QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 V L +V E L ++ D + ++KS + + + + H Sbjct: 77 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS----IGEAIQYLH 132 Query: 120 SHRVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 S + HRD+KP+NLL ++ +KL DFG A+ + T T +Y APE+ LG Sbjct: 133 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTEPCYTPYYVAPEV-LG 190 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS---M 233 + Y + D+WSLG I ++ F + + + PG+ + M Sbjct: 191 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------AISPGMKTRIRM 235 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 Y+ P+W+ + E+ + L+ +L +P +R++ + HP+ TK Sbjct: 236 GQYEFPNPEWSE---------VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 284 >6E4F-A nrPDB Length = 290 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 102/200 (51%), Gaps = 20/200 (10%) Query: 7 VEKIGEGTYGVVYKARNKLTGEV-VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVK 65 ++++G G +GVV K G+ VA+K I+ + +E I E ++ L+H +V+ Sbjct: 36 LKELGTGQFGVV--KYGKWRGQYDVAIKMIKEGSMSE---DEFIEEAKVMMNLSHEKLVQ 90 Query: 66 LLDVIHTENKLYLVFEFLHQ----DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 L V + ++++ E++ + + M T L + K + + + + S Sbjct: 91 LYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD----VCEAMEYLESK 146 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILLGCK 178 + LHRDL +N L+N +G +K++DFGL+R V YT V + + + PE+L+ K Sbjct: 147 QFLHRDLAARNCLVNDQGVVKVSDFGLSRY--VLDDEYTSSVGSKFPVRWSPPEVLMYSK 204 Query: 179 YYSTAVDIWSLGCIFAEMVT 198 +S+ DIW+ G + E+ + Sbjct: 205 -FSSKSDIWAFGVLMWEIYS 223 >3LLT-A nrPDB Length = 360 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/241 (26%), Positives = 108/241 (44%), Gaps = 41/241 (17%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 F + K+G+GT+G V ++ + A+K +R + +A E +LK++ + +I Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVR---NIKKYTRSAKIEADILKKIQNDDI 93 Query: 64 VKLLDVIHTENKLY-----LVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 V + +Y L+FE L L + + + G + IK Y ++L+ L + Sbjct: 94 NNNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYL 153 Query: 119 HSHRVLHRDLKPQNLLIN--------------TEG-----------AIKLADFGLARAFG 153 + H DLKP+N+L++ T+G IKL DFG A Sbjct: 154 RKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCA---- 209 Query: 154 VPVRTYTHEVV--TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQ 211 ++ H + T YRAPE++L + + D+WS GC+ AE+ T LF ++ Sbjct: 210 -TFKSDYHGSIINTRQYRAPEVILNLG-WDVSSDMWSFGCVLAELYTGSLLFRTHEHMEH 267 Query: 212 L 212 L Sbjct: 268 L 268 >3QUP-A nrPDB Length = 323 Score = 68.9 bits (167), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 101/214 (47%), Gaps = 17/214 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEV---VALKKIRLDTETEGVPSTAIREISLLKEL 58 + F +G+G +G V +A+ K VA+K ++ D +RE + +KE Sbjct: 23 QQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEF 82 Query: 59 NHPNIVKLLDV-IHTENKLYL-----VFEFL-HQDLKKFMDASALT----GIPLPLIKSY 107 +HP++ KL+ V + + K L + F+ H DL F+ AS + +PL + + Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRF 142 Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVT 165 + + G+ + S +HRDL +N ++ + + +ADFGL+R G R + Sbjct: 143 MVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLP 202 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTR 199 + + A E L Y+ D+W+ G E++TR Sbjct: 203 VKWLALESLAD-NLYTVHSDVWAFGVTMWEIMTR 235 >1NY3-A nrPDB Length = 400 Score = 68.9 bits (167), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 75/298 (25%), Positives = 129/298 (43%), Gaps = 53/298 (17%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISL-LKELNHPNIVKLLD 68 +G G G V + NK T E ALK + + P A RE+ L + P+IV+++D Sbjct: 70 LGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRASQCPHIVRIVD 122 Query: 69 VIHT----ENKLYLVFEFLH-----QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 V L +V E L ++ D + ++KS + + + + H Sbjct: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS----IGEAIQYLH 178 Query: 120 SHRVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 S + HRD+KP+NLL ++ +KL DFG A+ + T T +Y APE+ LG Sbjct: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEV-LG 236 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS---M 233 + Y + D+WSLG I ++ F + + + PG+ + M Sbjct: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------AISPGMKTRIRM 281 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 Y+ P+W+ + E+ + L+ +L +P +R++ + HP+ TK Sbjct: 282 GQYEFPNPEWSE---------VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 >4AW2-A nrPDB Length = 437 Score = 68.9 bits (167), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 100/227 (44%), Gaps = 16/227 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIRE-ISLLKELNH 60 E+F+ ++ IG G +G V + K +V A+K + + + RE +L + Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDS 133 Query: 61 PNIVKLLDVIHTENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 I L +N LYLV ++ L L KF D +P + + YL +++ + Sbjct: 134 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDR-----LPEEMARFYLAEMVIAI 188 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLA-RAFGVPVRTYTHEVVTLWYRAPEIL 174 H +HRD+KP N+L++ G I+LADFG + + V T Y +PEIL Sbjct: 189 DSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEIL 248 Query: 175 L----GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR 217 G Y D WSLG EM+ F +S ++ +I Sbjct: 249 QAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN 295 >2OZA-A nrPDB Length = 356 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 75/298 (25%), Positives = 129/298 (43%), Gaps = 53/298 (17%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISL-LKELNHPNIVKLLD 68 +G G G V + NK T E ALK + + P A RE+ L + P+IV+++D Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRASQCPHIVRIVD 78 Query: 69 VIHT----ENKLYLVFEFLH-----QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 V L +V E L ++ D + ++KS + + + + H Sbjct: 79 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS----IGEAIQYLH 134 Query: 120 SHRVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 S + HRD+KP+NLL ++ +KL DFG A+ + T T +Y APE+ LG Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEV-LG 192 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS---M 233 + Y + D+WSLG I ++ F + + + PG+ + M Sbjct: 193 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------AISPGMKTRIRM 237 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 Y+ P+W+ + E+ + L+ +L +P +R++ + HP+ TK Sbjct: 238 GQYEFPNPEWSE---------VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 286 >2BUJ-A nrPDB Length = 317 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 92/211 (43%), Gaps = 24/211 (11%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 ++K+GEG + V G ALK+I + + A RE + + NHPNI++L Sbjct: 34 IQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQD--REEAQREADMHRLFNHPNILRL 91 Query: 67 LDVIHTE----NKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 + E ++ +L+ F L ++++ D + I L + +GL Sbjct: 92 VAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNF--LTEDQILWLLLGICRGLEA 149 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV---------RTYTHEVVTLWY 168 H+ HRDLKP N+L+ EG L D G + V + + + T+ Y Sbjct: 150 IHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISY 209 Query: 169 RAPEILLGCKY--YSTAVDIWSLGCIFAEMV 197 RAPE+ + D+WSLGC+ M+ Sbjct: 210 RAPELFSVQSHCVIDERTDVWSLGCVLYAMM 240 >4Y93-A nrPDB Length = 446 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 99/198 (50%), Gaps = 16/198 (8%) Query: 7 VEKIGEGTYGVVYKARNKLTGEV-VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVK 65 ++++G G +GVV K G+ VA+K I+ + +E I E ++ L+H +V+ Sbjct: 193 LKELGTGQFGVV--KYGKWRGQYDVAIKMIKEGSMSE---DEFIEEAKVMMNLSHEKLVQ 247 Query: 66 LLDVIHTENKLYLVFEFLHQ----DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 L V + ++++ E++ + + M T L + K + + + + S Sbjct: 248 LYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD----VCEAMEYLESK 303 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLAR-AFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 + LHRDL +N L+N +G +K++DFG+ R + T + + +PE+L+ K + Sbjct: 304 QFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSK-F 362 Query: 181 STAVDIWSLGCIFAEMVT 198 S+ DIW+ G + E+ + Sbjct: 363 SSKSDIWAFGVLMWEIYS 380 >3G2F-A nrPDB Length = 336 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 78/311 (25%), Positives = 131/311 (42%), Gaps = 44/311 (14%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++N + +E IG G YG VYK L VA+K + I + L++ H Sbjct: 12 LDNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFINEKNIYRVPLME---H 66 Query: 61 PNIVKLL---DVIHTENKL--YLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 NI + + + + + ++ LV E+ + L K++ + + + +G Sbjct: 67 DNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLA---HSVTRG 123 Query: 115 LAFCHSH---------RVLHRDLKPQNLLINTEGAIKLADFGLARAF--------GVPVR 157 LA+ H+ + HRDL +N+L+ +G ++DFGL+ G Sbjct: 124 LAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDN 183 Query: 158 TYTHEVVTLWYRAPEILLG------CKYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEID 210 EV T+ Y APE+L G C+ VD+++LG I+ E+ R LFPG+S + Sbjct: 184 AAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPE 243 Query: 211 QLFRIFRTLGT-PDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHY 269 +G P + S +P FP+ A ++ S V L E Q Sbjct: 244 YQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPE-AWKENSLAVRSLKETIEDCWDQ---- 298 Query: 270 DPNKRISAKAA 280 D R++A+ A Sbjct: 299 DAEARLTAQCA 309 >3FXW-A nrPDB Length = 336 Score = 67.0 bits (162), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 72/294 (24%), Positives = 118/294 (40%), Gaps = 56/294 (19%) Query: 10 IGEGTYGVVYKARNKLTGEVVALK------KIRLDTETEGVPSTAIREISLLKELNHPNI 63 +G G G V + ++ TG+ ALK K R + + S P+I Sbjct: 37 LGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGG------------PHI 84 Query: 64 VKLLDVI----HTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 V +LDV H + L ++ E + +L + + + + F Sbjct: 85 VCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFL 144 Query: 119 HSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 HSH + HRD+KP+NLL + + +KL DFG A+ T +Y APE+ L Sbjct: 145 HSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKE--TTQNALQTPCYTPYYVAPEV-L 201 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT---S 232 G + Y + D+WSLG I M FP + G + + PG+ Sbjct: 202 GPEKYDKSCDMWSLGVI---MYILLCGFPP---------FYSNTG---QAISPGMKRRIR 246 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 + Y P+W+ + ED + L+ +L DP +R++ + HP+ Sbjct: 247 LGQYGFPNPEWSE---------VSEDAKQLIRLLLKTDPTERLTITQFMNHPWI 291 >4LRM-A nrPDB Length = 334 Score = 67.0 bits (162), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 97/214 (45%), Gaps = 30/214 (14%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVV----ALKKIRLDTETEGVPSTAIREI------ 52 F+K++ +G G +G VYK GE V A+K++R E A +EI Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-----EATSPKANKEILDEAYV 74 Query: 53 -SLLKELNHPNIVKLLDVIHTENKLYLV----FEFLHQDLKKFMDASALTGIPLPLIKSY 107 + + +P++ +LL + T + F L +++ D I + ++ Sbjct: 75 MASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKD-----NIGSQYLLNW 129 Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE---VV 164 Q+ +G+ + R++HRDL +N+L+ T +K+ DFGLA+ G + Y E V Sbjct: 130 CVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVP 189 Query: 165 TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 W IL + Y+ D+WS G E++T Sbjct: 190 IKWMALESILH--RIYTHQSDVWSYGVTVWELMT 221 >3UIM-A nrPDB Length = 326 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 100/209 (47%), Gaps = 10/209 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +NF +G G +G VYK R G +VA+K+++ + T+G E+ ++ H Sbjct: 30 DNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLK-EERTQGGELQFQTEVEMISMAVHR 87 Query: 62 NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQL--LQGLAFC 118 N+++L T + LV+ ++ + + + + PL K L +GLA+ Sbjct: 88 NLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYL 147 Query: 119 HSH---RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEIL 174 H H +++HRD+K N+L++ E + DFGLA+ T V T+ + APE L Sbjct: 148 HDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYL 207 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALF 203 K S D++ G + E++T + F Sbjct: 208 STGK-SSEKTDVFGYGVMLLELITGQRAF 235 >3OMV-A nrPDB Length = 307 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/227 (24%), Positives = 111/227 (48%), Gaps = 23/227 (10%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 +IG G++G VYK K G+V A+K +++ T E+++L++ H NI+ + Sbjct: 43 RIGSGSFGTVYKG--KWHGDV-AVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMG 99 Query: 69 VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL-------QGLAFCHSH 121 + T++ L +V ++ +S + + K +FQL+ QG+ + H+ Sbjct: 100 YM-TKDNLAIVTQWCE-------GSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAK 151 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLA--RAFGVPVRTYTHEVVTLWYRAPEI--LLGC 177 ++HRD+K N+ ++ +K+ DFGLA ++ + ++ + APE+ + Sbjct: 152 NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDN 211 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQ-LFRIFRTLGTPD 223 +S D++S G + E++T + + DQ +F + R +PD Sbjct: 212 NPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPD 258 >5TE0-A nrPDB Length = 347 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 94/210 (44%), Gaps = 23/210 (10%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVKL 66 E + EG + +V+ R G ALK++ ++ E + REI ++++L+ H NIV Sbjct: 25 EVLAEGGFAIVFLVRTS-NGMKCALKRMFVNNEHD--LQVCKREIQIMRDLSGHKNIVGY 81 Query: 67 LDVIHTENKLYLVFEFL-------HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 +D V+E L + M+ TG + + +A H Sbjct: 82 IDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLH 141 Query: 120 SHR--VLHRDLKPQNLLINTEGAIKLADFGLA-RAFGVP-------VRTYTHEVVTLWYR 169 + ++HRDLK +N+L++ G L DFG A F P V + TL YR Sbjct: 142 QCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYR 201 Query: 170 APEI--LLGCKYYSTAVDIWSLGCIFAEMV 197 APE+ L K +T DIW+LGC+ ++ Sbjct: 202 APEMVNLYSGKIITTKADIWALGCLLYKLC 231 >3KUL-B nrPDB Length = 325 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 97/200 (48%), Gaps = 11/200 (5%) Query: 7 VEKI-GEGTYGVVYKARNKLTGEV---VALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 +EKI G G G V R ++ G+ VA+K ++ TE + E S++ + +HPN Sbjct: 53 IEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY-TERQRRDFLSEASIMGQFDHPN 111 Query: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 I++L V+ +V E++ L F+ + L+ L + G+ + Sbjct: 112 IIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLV-GMLRGVGAGMRYLSDL 170 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFG---VPVRTYTHEVVTLWYRAPEILLGCK 178 +HRDL +N+L+++ K++DFGL+R T T + + + APE + + Sbjct: 171 GYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEA-IAFR 229 Query: 179 YYSTAVDIWSLGCIFAEMVT 198 +S+A D+WS G + E++ Sbjct: 230 TFSSASDVWSFGVVMWEVLA 249 >4Y83-A nrPDB Length = 332 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 75/283 (26%), Positives = 118/283 (41%), Gaps = 50/283 (17%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 I G +G VY A++ T + +A K I +D + PS ++ + H NI +L Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIPVD---QFKPS----DVEIQACFRHENIAELYGA 133 Query: 70 IHTENKLYLVFEFLHQD--LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 + ++L E L+K + + + ++ L+GL F HS +V+H D Sbjct: 134 VLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHV---LKGLDFLHSKKVIHHD 190 Query: 128 LKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIW 187 +KP N++ + A+ L DFGL+ V T Y +PE++L C+ +ST DI+ Sbjct: 191 IKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL-CRGHSTKADIY 248 Query: 188 SLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD 247 SLG M T GTP P V P + ++P + Sbjct: 249 SLGATLIHMQT---------------------GTP-----PWVKRYP--RSAYPSYLYI- 279 Query: 248 FSKVVPPLDEDG-------RSLLSQMLHYDPNKRISAKAALAH 283 K PPL++ R L+ L +PN R A L H Sbjct: 280 IHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKH 322 >2QKW-B nrPDB Length = 321 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 102/209 (48%), Gaps = 19/209 (9%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 NF IG G +G VYK + G VALK+ R ++G+ EI L HP+ Sbjct: 40 NFDHKFLIGHGVFGKVYKGVLR-DGAKVALKR-RTPESSQGIEEFET-EIETLSFCRHPH 96 Query: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQ-------G 114 +V L+ N++ L+++++ +LK+ L G LP + Q L+ G Sbjct: 97 LVSLIGFCDERNEMILIYKYMENGNLKRH-----LYGSDLPTMSMSWEQRLEICIGAARG 151 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--TLWYRAPE 172 L + H+ ++HRD+K N+L++ K+ DFG+++ +T+ VV TL Y PE Sbjct: 152 LHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPE 211 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRA 201 + + + D++S G + E++ R+ Sbjct: 212 YFIKGRLTEKS-DVYSFGVVLFEVLCARS 239 >3ZBF-A nrPDB Length = 322 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 66/267 (24%), Positives = 119/267 (44%), Gaps = 33/267 (12%) Query: 10 IGEGTYGVVYKAR-----NKLTGEV-VALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 +G G +G VY+ +GE+ VA+K ++ + T+ ++E L+ + NHPNI Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGS-TDQEKIEFLKEAHLMSKFNHPNI 99 Query: 64 VKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLP-----LIKSYLFQLLQGLAF 117 +K L V Y++ E + DL ++ + + P + + +G + Sbjct: 100 LKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVY 159 Query: 118 CHSHRVLHRDLKPQNLLINTEG-----AIKLADFGLARAF--GVPVRTYTHEVVTLWYRA 170 +HRDL +N L++ + +K+ DFGLAR R ++ + + A Sbjct: 160 LERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMA 219 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQL------FRIFRTLGTPD 223 PE L+ ++T D+WS G + E++T +P S +D L R+ PD Sbjct: 220 PESLMD-GIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPD 278 Query: 224 EVVWPGVTSM----PDYKPSFPKWARQ 246 + +W +T PD +P+F + Q Sbjct: 279 D-LWNLMTQCWAQEPDQRPTFHRIQDQ 304 >5LPZ-A nrPDB Length = 332 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 62/216 (28%), Positives = 102/216 (47%), Gaps = 20/216 (9%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 F IG G +G VYKA K G VA+KK+ + +G + E+ + ++ H N Sbjct: 18 GFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKL-IHVSGQG-DREFMAEMETIGKIKHRN 74 Query: 63 IVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPL--PLIKSYLFQLLQGLAFCH 119 +V LL ++ LV+EF+ + L+ + G+ L + +GLAF H Sbjct: 75 LVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134 Query: 120 ---SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 S ++HRD+K N+L++ +++DFG+AR TH V+ P + Sbjct: 135 HNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSA---MDTHLSVSTLAGTPG-YVP 190 Query: 177 CKYY-----STAVDIWSLGCIFAEMVTRRALFPGDS 207 +YY ST D++S G + E++T + P DS Sbjct: 191 PEYYQSFRCSTKGDVYSYGVVLLELLTGKR--PTDS 224 >6BFN-A nrPDB Length = 342 Score = 65.1 bits (157), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 49/153 (32%), Positives = 68/153 (44%), Gaps = 5/153 (3%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 NF + KIGEG +G VY+A + T V K D E V + + E+ L HPN Sbjct: 23 NFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPN 82 Query: 63 IVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPL--PLIKSYLFQLLQGLAFCH 119 IV LV+ FL + L+ + PL P L + + F H Sbjct: 83 IVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLH 142 Query: 120 --SHRVLHRDLKPQNLLINTEGAIKLADFGLAR 150 S ++H D+K N+L++ KL DFGLAR Sbjct: 143 QDSPSLIHGDIKSSNVLLDERLTPKLGDFGLAR 175 >5LPV-A nrPDB Length = 296 Score = 65.1 bits (157), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 62/217 (28%), Positives = 102/217 (47%), Gaps = 20/217 (9%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 F IG G +G VYKA K G VA+KK+ + +G + E+ + ++ H Sbjct: 17 NGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKL-IHVSGQG-DREFMAEMETIGKIKHR 73 Query: 62 NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPL--PLIKSYLFQLLQGLAFC 118 N+V LL ++ LV+EF+ + L+ + G+ L + +GLAF Sbjct: 74 NLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFL 133 Query: 119 H---SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 H S ++HRD+K N+L++ +++DFG+AR TH V+ P + Sbjct: 134 HHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSA---MDTHLSVSTLAGTPG-YV 189 Query: 176 GCKYY-----STAVDIWSLGCIFAEMVTRRALFPGDS 207 +YY ST D++S G + E++T + P DS Sbjct: 190 PPEYYQSFRCSTKGDVYSYGVVLLELLTGKR--PTDS 224 >3I81-A nrPDB Length = 315 Score = 65.1 bits (157), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 47/205 (22%), Positives = 100/205 (48%), Gaps = 16/205 (7%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTA----IREISLLKELNHPNIV 64 ++G+G++G+VY+ K + ++ + T E + E S++KE N ++V Sbjct: 25 ELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVV 84 Query: 65 KLLDVIHTENKLYLVFEFLHQ-DLKKF-------MDASALTGIP-LPLIKSYLFQLLQGL 115 +LL V+ ++ E + + DLK + M+ + + P L + ++ G+ Sbjct: 85 RLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGM 144 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYTHEVVTLWYRAPEI 173 A+ ++++ +HRDL +N ++ + +K+ DFG+ R R ++ + + +PE Sbjct: 145 AYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPES 204 Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVT 198 L ++T D+WS G + E+ T Sbjct: 205 LKD-GVFTTYSDVWSFGVVLWEIAT 228 >2H34-A nrPDB Length = 309 Score = 65.1 bits (157), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 94/202 (46%), Gaps = 10/202 (4%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELNHPNIVKLLD 68 +G G G VY+A + + +VALK + ++ V T + RE L P++V + D Sbjct: 42 VGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHD 101 Query: 69 VIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPL--PLIKSYLFQLLQGLAFCHSHRVLH 125 + +LY+ ++ DL + PL P + + Q+ L H+ H Sbjct: 102 FGEIDGQLYVDMRLINGVDLAAMLRRQG----PLAPPRAVAIVRQIGSALDAAHAAGATH 157 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGCKYYSTAV 184 RD+KP+N+L++ + L DFG+A A T V TL+Y APE + + Sbjct: 158 RDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPE-RFSESHATYRA 216 Query: 185 DIWSLGCIFAEMVTRRALFPGD 206 DI++L C+ E +T + GD Sbjct: 217 DIYALTCVLYECLTGSPPYQGD 238 >3CJF-A nrPDB Length = 309 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 71/274 (25%), Positives = 120/274 (43%), Gaps = 35/274 (12%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-------NHPN 62 +G G +G V +A + + + + EG + R +L+ EL +H N Sbjct: 35 LGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR--ALMSELKILIHIGHHLN 92 Query: 63 IVKLLDVIHTENK-LYLVFEFLH-QDLKKFMDASALTGIP----------LPLIKSYLFQ 110 +V LL L ++ EF +L ++ + +P L + Y FQ Sbjct: 93 VVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQ 152 Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLAR-AFGVP--VRTYTHEVVTLW 167 + +G+ F S + +HRDL +N+L++ + +K+ DFGLAR + P VR + W Sbjct: 153 VAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKW 212 Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRAL-FPGDSEIDQLFRIFRTLGTPDEVV 226 APE + + Y+ D+WS G + E+ + A +PG +ID+ F R L + Sbjct: 213 M-APETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPG-VKIDEEF--CRRLKEGTRMR 267 Query: 227 WPGVTSMPDYKPSFPKW-----ARQDFSKVVPPL 255 P T+ Y+ W R FS++V L Sbjct: 268 APDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL 301 >5HI2-A nrPDB Length = 283 Score = 64.7 bits (156), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 60/255 (23%), Positives = 118/255 (46%), Gaps = 31/255 (12%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 ++IG G++G VYK K G+V K+ + + + E+ +L++ H NI+ + Sbjct: 26 QRIGSGSFGTVYKG--KWHGDVAV--KMLTPQQLQAFKN----EVGVLRKTRHVNILLFM 77 Query: 68 DVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 T+ +L +V ++ L + AS T + + Q +G+ + H+ ++HR Sbjct: 78 GY-STKPQLAIVTQWCEGSSLYHHLHASE-TKFEMKKLIDIARQTARGMDYLHAKSIIHR 135 Query: 127 DLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT---LWYRAPEI--LLGCKYYS 181 DLK N+ ++ + +K+ DFGLA ++ E ++ LW APE+ + YS Sbjct: 136 DLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM-APEVIRMQDSNPYS 194 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF-RTLGTPD-------------EVVW 227 D+++ G + E++T + + + DQ+ + R +PD ++ Sbjct: 195 FQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMA 254 Query: 228 PGVTSMPDYKPSFPK 242 + D +PSFP+ Sbjct: 255 ECLKKKRDERPSFPR 269 >2OGV-A nrPDB Length = 317 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 97/217 (44%), Gaps = 25/217 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL----DTETEGVPSTAIREISLLKE 57 N Q + +G G +G V +A G+ A+ K+ + T + E+ ++ Sbjct: 38 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSH 97 Query: 58 LN-HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFM------DASALTGIPLPL--IKSY 107 L H NIV LL + ++ E+ + DL F+ D G PL L + + Sbjct: 98 LGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHF 157 Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT-- 165 Q+ QG+AF S +HRD+ +N+L+ K+ DFGLAR + ++ +V Sbjct: 158 SSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLAR----DIMNDSNYIVKGN 213 Query: 166 ----LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 + + APE + C Y+ D+WS G + E+ + Sbjct: 214 ARLPVKWMAPESIFDC-VYTVQSDVWSYGILLWEIFS 249 >3HNG-A nrPDB Length = 360 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 39/118 (33%), Positives = 64/118 (54%), Gaps = 7/118 (5%) Query: 86 DLKKFMDASALTGIPLPL--IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKL 143 D+++ D+ P+ + + SY FQ+ +G+ F S + +HRDL +N+L++ +K+ Sbjct: 181 DVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKI 240 Query: 144 ADFGLARA-FGVP--VRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 DFGLAR + P VR + W APE + K YST D+WS G + E+ + Sbjct: 241 CDFGLARDIYKNPDYVRKGDTRLPLKWM-APESIFD-KIYSTKSDVWSYGVLLWEIFS 296 >3MDY-A nrPDB Length = 337 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 84/308 (27%), Positives = 138/308 (44%), Gaps = 57/308 (18%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + Q V++IG+G YG V+ K GE VA+K E T I + L++ H Sbjct: 37 KQIQMVKQIGKGRYGEVWMG--KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMR---HE 91 Query: 62 NIVKLL--DVIHTEN--KLYLVFEFLHQD--LKKFMDASALTGIPLPLIKSYL---FQLL 112 NI+ + D+ T + +LYL+ ++ H++ L ++ ++ L KS L + + Sbjct: 92 NILGFIAADIKGTGSWTQLYLITDY-HENGSLYDYLKSTTLDA------KSMLKLAYSSV 144 Query: 113 QGLAFCHSHR----------VLHRDLKPQNLLINTEGAIKLADFGLARAF-------GVP 155 GL CH H + HRDLK +N+L+ G +AD GLA F +P Sbjct: 145 SGL--CHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIP 202 Query: 156 VRTYTHEVVTLWYRAPEIL---LGCKYYSTAV--DIWSLGCIFAEMVTRRALFPGDSEID 210 T V T Y PE+L L ++ + + D++S G I E V RR + G E Sbjct: 203 PNT---RVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWE-VARRCVSGGIVEEY 258 Query: 211 QLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP-KWARQDFSKVVPPLDEDGRSLLSQMLHY 269 QL P + + +PSFP +W+ + L + G+ L+++ + Sbjct: 259 QLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDEC------LRQMGK-LMTECWAH 311 Query: 270 DPNKRISA 277 +P R++A Sbjct: 312 NPASRLTA 319 >5GRN-A nrPDB Length = 356 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 65/272 (23%), Positives = 113/272 (41%), Gaps = 46/272 (16%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVKLL 67 K+ EGT + +++ + V LK +E + + S E+ ++ L H NIV LL Sbjct: 61 KVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMS----ELKIMTHLGPHLNIVNLL 116 Query: 68 DVIHTENKLYLVFEF-------------------------LHQDLKKFMDASALTGIPLP 102 +Y++ E+ L ++K + G+ L Sbjct: 117 GACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLL 176 Query: 103 LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE 162 + S+ +Q+ +G+ F S +HRDL +N+L+ +K+ DFGLAR + Y + Sbjct: 177 DLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI-MHDSNYVSK 235 Query: 163 VVTLW---YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRAL-FPG---DSEIDQLFRI 215 T + APE + Y+T D+WS G + E+ + +PG DS + Sbjct: 236 GSTFLPVKWMAPESIFD-NLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKS 294 Query: 216 FRTLGTPD-------EVVWPGVTSMPDYKPSF 240 + PD E++ S P+ +PSF Sbjct: 295 GYRMAKPDHATSEVYEIMVKCWNSEPEKRPSF 326 >1PY5-A nrPDB Length = 326 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 102/227 (44%), Gaps = 31/227 (13%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 E IG+G +G V+ R K GE VA+K E I + +L+ H NI+ + Sbjct: 35 ESIGKGRFGEVW--RGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLR---HENILGFI 89 Query: 68 DVIHTEN----KLYLVFEF-LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH- 121 + +N +L+LV ++ H L +++ +T +IK L GLA H Sbjct: 90 AADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT--VEGMIKLAL-STASGLAHLHMEI 146 Query: 122 -------RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----THEVVTLWYRA 170 + HRDLK +N+L+ G +AD GLA T H V T Y A Sbjct: 147 VGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMA 206 Query: 171 PEIL---LGCKYYST--AVDIWSLGCIFAEMVTRRALFPGDSEIDQL 212 PE+L + K++ + DI+++G +F E + RR G E QL Sbjct: 207 PEVLDDSINMKHFESFKRADIYAMGLVFWE-IARRCSIGGIHEDYQL 252 >4EUU-A nrPDB Length = 319 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 96/211 (45%), Gaps = 31/211 (14%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 +G+G V++ R+K TG++ A+K + V +RE +LK+LNH NIVKL + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 75 Query: 70 IH--TENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 T L+ EF L+ L+ + S G+P L ++ G+ + Sbjct: 76 EEETTTRHKVLIMEFCPCGSLYTVLE---EPSNAYGLPESEFLIVLRDVVGGMNHLRENG 132 Query: 123 VLHRDLKPQNLL--INTEG--AIKLADFGLARAFGVPVRTYTHEVVTLW----YRAPEIL 174 ++HR++KP N++ I +G KL DFG AR + V+L+ Y P++ Sbjct: 133 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVSLYGTEEYLHPDMY 187 Query: 175 LGC-------KYYSTAVDIWSLGCIFAEMVT 198 K Y VD+WS+G F T Sbjct: 188 ERAVLRKDHQKKYGATVDLWSIGVTFYHAAT 218 >4JLC-A nrPDB Length = 657 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 70/245 (28%), Positives = 107/245 (43%), Gaps = 37/245 (15%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 +G+G V++ R+K TG++ A+K + V +RE +LK+LNH NIVKL + Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 74 Query: 70 ---IHTENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 T +K+ L+ EF L+ L+ + S G+P L ++ G+ + Sbjct: 75 EEETTTRHKV-LIMEFCPCGSLYTVLE---EPSNAYGLPESEFLIVLRDVVGGMNHLREN 130 Query: 122 RVLHRDLKPQNLL--INTEG--AIKLADFGLARAFG--------VPVRTYTHEVVTLWYR 169 ++HRD+KP N++ I +G KL DFG AR Y H ++ R Sbjct: 131 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP--DMYER 188 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 A K Y VD+WS+G F T P FR F EV++ Sbjct: 189 AVLRKDHQKKYGATVDLWSVGVTFYHAAT--GSLP--------FRPFEGPRRNKEVMYKI 238 Query: 230 VTSMP 234 +T P Sbjct: 239 ITGKP 243 >5C26-A nrPDB Length = 299 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 52/224 (23%), Positives = 104/224 (46%), Gaps = 13/224 (5%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE--GVPSTAIREISLLKELNHPNIVK 65 +++G G +G V K ++ V + L E + + E +++++L++P IV+ Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 66 LLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 ++ + E+ + LV E L K++ + + I + Q+ G+ + + Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQN--RHVKDKNIIELVHQVSMGMKYLEESNFV 149 Query: 125 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILLGCKYYS 181 HRDL +N+L+ T+ K++DFGL++A Y + W + APE + K +S Sbjct: 150 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-FS 208 Query: 182 TAVDIWSLGCIFAEMVTR-RALFPG--DSEIDQLFRIFRTLGTP 222 + D+WS G + E + + + G SE+ + +G P Sbjct: 209 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 252 >4EUT-A nrPDB Length = 396 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 96/211 (45%), Gaps = 31/211 (14%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 +G+G V++ R+K TG++ A+K + V +RE +LK+LNH NIVKL + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 75 Query: 70 IH--TENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 T L+ EF L+ L+ + S G+P L ++ G+ + Sbjct: 76 EEETTTRHKVLIMEFCPCGSLYTVLE---EPSNAYGLPESEFLIVLRDVVGGMNHLRENG 132 Query: 123 VLHRDLKPQNLL--INTEG--AIKLADFGLARAFGVPVRTYTHEVVTLW----YRAPEIL 174 ++HR++KP N++ I +G KL DFG AR + V+L+ Y P++ Sbjct: 133 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVSLYGTEEYLHPDMY 187 Query: 175 LGC-------KYYSTAVDIWSLGCIFAEMVT 198 K Y VD+WS+G F T Sbjct: 188 ERAVLRKDHQKKYGATVDLWSIGVTFYHAAT 218 >4LQP-A nrPDB Length = 508 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 48/154 (31%), Positives = 75/154 (48%), Gaps = 6/154 (3%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTA--IREISLLKELN 59 E+F V+ IG+G +G V + K TG++ A+K + L +E A E +L + Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTL-LKSEMYKKDQLAHVKAERDVLAGSD 160 Query: 60 HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 P +V L LYL+ EFL DL + L + + Y+ + + + Sbjct: 161 SPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQL--FTEDVTRFYMAECILAIETI 218 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF 152 H +HR +KP N+LI+ G IKL+DFGL+ F Sbjct: 219 HKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGF 252 >6O8B-A nrPDB Length = 665 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 69/242 (28%), Positives = 105/242 (43%), Gaps = 31/242 (12%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 +G+G V++ R+K TG++ A+K + V +RE +LK+LNH NIVKL + Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 81 Query: 70 IH--TENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 T L+ EF L+ L+ + S G+P L ++ G+ + Sbjct: 82 EEETTTRHKVLIMEFCPCGSLYTVLE---EPSNAYGLPESEFLIVLRDVVGGMNHLRENG 138 Query: 123 VLHRDLKPQNLL--INTEG--AIKLADFGLARAFGVP---VRTYTHEVV---TLWYRAPE 172 ++HR++KP N++ I +G KL DFG AR V Y E ++ RA Sbjct: 139 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVL 198 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 K Y VD+WS+G F T P FR F EV++ +T Sbjct: 199 RKDHQKKYGATVDLWSIGVTFYHAAT--GSLP--------FRPFEGPRRNKEVMYKIITG 248 Query: 233 MP 234 P Sbjct: 249 KP 250 >4F0G-A nrPDB Length = 287 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 98/209 (46%), Gaps = 18/209 (8%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRL---DTETEGVP--STAIREISLLKELNHPN 62 ++IG+G +G+V+K R VVA+K + L + ETE + RE+ ++ LNHPN Sbjct: 25 KQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPN 84 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 IVKL ++H ++ + F + +D + + L + + G+ + + Sbjct: 85 IVKLYGLMHNPPRMVMEFVPCGDLYHRLLDKAHPIKWSVKL--RLMLDIALGIEYMQNQN 142 Query: 123 --VLHRDLKPQNLLI-----NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 ++HRDL+ N+ + N K+ADFGL++ V + + + + APE + Sbjct: 143 PPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ---SVHSVSGLLGNFQWMAPETIG 199 Query: 176 G-CKYYSTAVDIWSLGCIFAEMVTRRALF 203 + Y+ D +S I ++T F Sbjct: 200 AEEESYTEKADTYSFAMILYTILTGEGPF 228 >4FL3-A nrPDB Length = 635 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 47/197 (23%), Positives = 94/197 (47%), Gaps = 10/197 (5%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE--GVPSTAIREISLLKELNHPNIVK 65 +++G G +G V K ++ V + L E + + E +++++L++P IV+ Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 66 LLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 ++ + E+ + LV E L K++ + + I + Q+ G+ + + Sbjct: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQN--RHVKDKNIIELVHQVSMGMKYLEESNFV 491 Query: 125 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILLGCKYYS 181 HRDL +N+L+ T+ K++DFGL++A Y + W + APE + K +S Sbjct: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-FS 550 Query: 182 TAVDIWSLGCIFAEMVT 198 + D+WS G + E + Sbjct: 551 SKSDVWSFGVLMWEAFS 567 >6NT9-A nrPDB Length = 742 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 68/244 (27%), Positives = 104/244 (42%), Gaps = 35/244 (14%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 +G+G V++ R+K TG++ A+K + V +RE +LK+LNH NIVKL + Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 73 Query: 70 IH--TENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 T L+ EF L+ L+ + S G+P L ++ G+ + Sbjct: 74 EEETTTRHKVLIMEFCPCGSLYTVLE---EPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 Query: 123 VLHRDLKPQNLL--INTEG--AIKLADFGLARAFG--------VPVRTYTHEVVTLWYRA 170 ++HR++KP N++ I +G KL DFG AR Y H ++ RA Sbjct: 131 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP--DMYERA 188 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 K Y VD+WS+G F T P FR F EV++ + Sbjct: 189 VLRKDHQKKYGATVDLWSIGVTFYHAAT--GSLP--------FRPFEGPRRNKEVMYKII 238 Query: 231 TSMP 234 T P Sbjct: 239 TGKP 242 >6GQK-A nrPDB Length = 328 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 70/277 (25%), Positives = 122/277 (44%), Gaps = 43/277 (15%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NHPNIVKLL 67 K+ E T + K+ +T V LK TE E + S E+ +L L NH NIV LL Sbjct: 56 KVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMS----ELKVLSYLGNHENIVNLL 111 Query: 68 DVIHTENKLYLVFEFL-HQDLKKFMDASALTGIP--------------LPLIKSYLFQLL 112 ++ E+ + DL F+ +P L + S+ +Q+ Sbjct: 112 GACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVA 171 Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV------VTL 166 +G+AF S +HRDL +N+L+ K+ DFGLAR ++ ++ V + + Sbjct: 172 KGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLAR----DIKNDSNYVDKGNARLPV 227 Query: 167 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPG---DSEIDQLFRIFRTLGTP 222 + APE + Y+ D+WS G E+ + + +PG DS+ ++ + + +P Sbjct: 228 KWMAPESIFN-SVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSP 286 Query: 223 D-------EVVWPGVTSMPDYKPSFPKWARQDFSKVV 252 + +++ + PD +P+F K QD K + Sbjct: 287 EYAPAEMYDIMKTCWDADPDKRPTF-KQIVQDIEKQI 322 >5HIE-A nrPDB Length = 302 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 54/222 (24%), Positives = 105/222 (47%), Gaps = 16/222 (7%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 ++IG G++G VYK K G+V K+ + + + E+ +L++ H NI+ + Sbjct: 42 QRIGSGSFGTVYKG--KWHGDVAV--KMLTPQQLQAFKN----EVGVLRKTRHVNILLFM 93 Query: 68 DVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 T+ +L +V ++ T + + Q QG+ + H+ ++HRD Sbjct: 94 GY-STKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRD 152 Query: 128 LKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT---LWYRAPEI--LLGCKYYST 182 LK N+ ++ + +K+ DFGLA ++ E ++ LW APE+ + YS Sbjct: 153 LKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM-APEVIRMQDKNPYSF 211 Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQ-LFRIFRTLGTPD 223 D+++ G + E++T + + + DQ +F + R +PD Sbjct: 212 QSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPD 253 >2WTK-B nrPDB Length = 373 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 70/304 (23%), Positives = 118/304 (38%), Gaps = 40/304 (13%) Query: 21 ARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF 80 AR K TGE V +++I L+ + + + E+ + K NHPNIV +N+L++V Sbjct: 30 ARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVT 89 Query: 81 EFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEG 139 F+ + K + + G+ I L +L+ L + H +HR +K ++LI+ +G Sbjct: 90 SFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDG 149 Query: 140 AIKLADFGLARAFGVPVRTYTHEVV---------TLWYRAPEIL-LGCKYYSTAVDIWSL 189 + L+ GL + VV L + +PE+L + Y DI+S+ Sbjct: 150 KVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSV 207 Query: 190 GCIFAEMVTRRALFPGDSEIDQLFRIFR-----------------TLGTPDEVVWPGV-- 230 G E+ F L T+ V G+ Sbjct: 208 GITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSD 267 Query: 231 ---TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 TS P +PS + + P + Q L +P+ R SA L H FF+ Sbjct: 268 SLTTSTP--RPSNGDSPSHPYHRTFSP---HFHHFVEQCLQRNPDARPSASTLLNHSFFK 322 Query: 288 DVTK 291 + + Sbjct: 323 QIKR 326 >5VDK-A nrPDB Length = 297 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 78/307 (25%), Positives = 124/307 (40%), Gaps = 65/307 (21%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIREISLLKEL-NHP 61 F +VEKIG G +G VYK +L G V A+K+ + T TE ++A+ E+ L +HP Sbjct: 17 FLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR-SMKTFTELSNENSALHEVYAHAVLGHHP 75 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTG--IPLPLIKSYLFQLLQGLAFC 118 ++V+ ++ + + E+ + L+ + + +G P +K L Q+ GL + Sbjct: 76 HVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYI 135 Query: 119 HSHRVLHRDLKPQNLLI------NTEGAI-----------------KLADFGLARAFGVP 155 H+ ++H D+KP N+ I + G I K+ D G A + P Sbjct: 136 HNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKP 195 Query: 156 VRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRI 215 E + A EIL + DI++LG A Sbjct: 196 KV----EEGDSRFLANEILQEDYRHLPKADIFALGLTIA--------------------- 230 Query: 216 FRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI 275 V G S+P ++ + +F V L E SLL M+ D +R Sbjct: 231 ----------VAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRP 280 Query: 276 SAKAALA 282 SA AALA Sbjct: 281 SA-AALA 286 >5XD6-A nrPDB Length = 305 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 98/214 (45%), Gaps = 22/214 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +N+ IGEG+YG V+ K +G+ A+KK+ + + + ++S++ L Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD---QEFLAQVSMVSRLRQE 77 Query: 62 NIVKLLDVIHTENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSY-----LFQL 111 N+V LL L +E+ LH L P P++ + Sbjct: 78 NVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQ--PGPVLSWHQRVKIAVGA 135 Query: 112 LQGLAFCHSH---RVLHRDLKPQNLLINTEGAIKLADFGLA-RAFGVPVRTYTHEVV-TL 166 +GL + H V+HRD+K N+L+ + K+ADF L+ +A + R ++ V+ T Sbjct: 136 ARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTF 195 Query: 167 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRR 200 Y APE + ST D++S G + E++T R Sbjct: 196 GYHAPEYAM-TGTLSTKSDVYSFGVVLLELLTGR 228 >3G0E-A nrPDB Length = 336 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 71/250 (28%), Positives = 112/250 (44%), Gaps = 43/250 (17%) Query: 9 KIGEGT-YGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NHPNIVKL 66 K+ E T YG++ K+ +T V LK TE E + S E+ +L L NH NIV L Sbjct: 61 KVVEATAYGLI-KSDAAMTVAVKMLKPSAHLTEREALMS----ELKVLSYLGNHMNIVNL 115 Query: 67 LDVIHTENKLYLVFEFL-HQDLKKFMDA---SALTGIPLPLI-------------KSYLF 109 L ++ E+ + DL F+ S + P I S+ + Sbjct: 116 LGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSY 175 Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT---- 165 Q+ +G+AF S +HRDL +N+L+ K+ DFGLAR ++ ++ VV Sbjct: 176 QVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLAR----DIKNDSNYVVKGNAR 231 Query: 166 --LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPG---DSE----IDQLFRI 215 + + APE + C Y+ D+WS G E+ + + +PG DS+ I + FR+ Sbjct: 232 LPVKWMAPESIFNC-VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRM 290 Query: 216 FRTLGTPDEV 225 P E+ Sbjct: 291 LSPEHAPAEM 300 >4XUF-A nrPDB Length = 297 Score = 60.8 bits (146), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 53/230 (23%), Positives = 99/230 (43%), Gaps = 38/230 (16%) Query: 2 ENFQKVEKIGEGTYGVVYKARN---KLTGEVVALKKIRLDTETEGVPSTAI-REISLLKE 57 EN + + +G G +G V A TG + + L + + A+ E+ ++ + Sbjct: 9 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQ 68 Query: 58 L-NHPNIVKLLDVIHTENKLYLVFEFL----------------------HQDLKKFMDAS 94 L +H NIV LL +YL+FE+ +++ K+ + Sbjct: 69 LGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEE 128 Query: 95 ALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV 154 L + + + +Q+ +G+ F +HRDL +N+L+ +K+ DFGLAR Sbjct: 129 DLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLAR---- 184 Query: 155 PVRTYTHEVVT------LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 + + ++ VV + + APE L Y+ D+WS G + E+ + Sbjct: 185 DIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFS 233 >5X02-A nrPDB Length = 347 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 53/230 (23%), Positives = 99/230 (43%), Gaps = 38/230 (16%) Query: 2 ENFQKVEKIGEGTYGVVYKARN---KLTGEVVALKKIRLDTETEGVPSTAI-REISLLKE 57 EN + + +G G +G V A TG + + L + + A+ E+ ++ + Sbjct: 48 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQ 107 Query: 58 L-NHPNIVKLLDVIHTENKLYLVFEFL----------------------HQDLKKFMDAS 94 L +H NIV LL +YL+FE+ +++ K+ + Sbjct: 108 LGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEE 167 Query: 95 ALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV 154 L + + + +Q+ +G+ F +HRDL +N+L+ +K+ DFGLAR Sbjct: 168 DLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLAR---- 223 Query: 155 PVRTYTHEVVT------LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 + + ++ VV + + APE L Y+ D+WS G + E+ + Sbjct: 224 DIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFS 272 >3Q4U-A nrPDB Length = 301 Score = 60.5 bits (145), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 91/220 (41%), Gaps = 29/220 (13%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 +E +G+G YG V+ R GE VA+K E T + +L+ H NI+ Sbjct: 13 LECVGKGRYGEVW--RGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLR---HENILGF 67 Query: 67 L--DVI--HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH- 121 + D+ H+ +L+L+ + ++ D LT + + + GLA H Sbjct: 68 IASDMTSRHSSTQLWLITHY--HEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEI 125 Query: 122 -------RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----THEVVTLWYRA 170 + HRDLK +N+L+ G +AD GLA V T Y A Sbjct: 126 FGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMA 185 Query: 171 PEIL-----LGCKYYSTAVDIWSLGCIFAEMVTRRALFPG 205 PE+L + C VDIW+ G + E V RR + G Sbjct: 186 PEVLDETIQVDCFDSYKRVDIWAFGLVLWE-VARRMVSNG 224 >3VHK-A nrPDB Length = 368 Score = 60.5 bits (145), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 49/159 (30%), Positives = 78/159 (49%), Gaps = 14/159 (8%) Query: 106 SYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLAR-AFGVP--VRTYTHE 162 Y FQ+ +G+ F S + +HRDL +N+L++ + +K+ DFGLAR + P VR Sbjct: 204 CYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDAR 263 Query: 163 VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRAL-FPGDSEIDQLFRIFRTLGT 221 + W APE + + Y+ D+WS G + E+ + A +PG +ID+ F R L Sbjct: 264 LPLKWM-APETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPG-VKIDEEF--CRRLKE 318 Query: 222 PDEVVWPGVTSMPDYKPSFPKW-----ARQDFSKVVPPL 255 + P T+ Y+ W R FS++V L Sbjct: 319 GTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL 357 >3PP0-A nrPDB Length = 338 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 52/204 (25%), Positives = 95/204 (46%), Gaps = 15/204 (7%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVV----ALKKIRLDTETEGVPSTAIREISLLKELN 59 +KV+ +G G +G VYK GE V A+K +R +T + + E ++ + Sbjct: 19 LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKA-NKEILDEAYVMAGVG 77 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQD--LKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 P + +LL + T + + LV + + L + G L ++ Q+ +G+++ Sbjct: 78 SPYVSRLLGICLT-STVQLVTQLMPYGCLLDHVRENRGRLGSQDLL--NWCMQIAKGMSY 134 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE---VVTLWYRAPEIL 174 R++HRDL +N+L+ + +K+ DFGLAR + Y + V W IL Sbjct: 135 LEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESIL 194 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVT 198 + ++ D+WS G E++T Sbjct: 195 R--RRFTHQSDVWSYGVTVWELMT 216 >3BEA-A nrPDB Length = 333 Score = 58.5 bits (140), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 54/221 (24%), Positives = 96/221 (43%), Gaps = 29/221 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL----DTETEGVPSTAIREISLLKE 57 N Q + +G G +G V +A G+ A+ K+ + T + E+ ++ Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSH 105 Query: 58 LN-HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMD------------ASALTGIPLPL 103 L H NIV LL + ++ E+ + DL F+ A A + + Sbjct: 106 LGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRD 165 Query: 104 IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV 163 + + Q+ QG+AF S +HRD+ +N+L+ K+ DFGLAR + ++ + Sbjct: 166 LLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLAR----DIMNDSNYI 221 Query: 164 VT------LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 V + + APE + C Y+ D+WS G + E+ + Sbjct: 222 VKGNARLPVKWMAPESIFDC-VYTVQSDVWSYGILLWEIFS 261 >4Y12-A nrPDB Length = 375 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 48/178 (26%), Positives = 91/178 (51%), Gaps = 22/178 (12%) Query: 54 LLKELNHPNIVKLLDVI-----HTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSY 107 L E+ HP+IV++ + + H + Y+V E++ Q LK+ S +P+ +Y Sbjct: 171 FLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR----SKGQKLPVAEAIAY 226 Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW 167 L ++L L++ HS +++ DLKP+N+++ TE +KL D G + ++ + T Sbjct: 227 LLEILPALSYLHSIGLVYNDLKPENIML-TEEQLKLIDLGAVSR----INSFGYLYGTPG 281 Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMV----TRRALF-PGDSEIDQLFRIFRTLG 220 ++APEI+ + A DI+++G A + TR + G E D + + + + G Sbjct: 282 FQAPEIVRTGP--TVATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYG 337 >3KRL-A nrPDB Length = 335 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 54/223 (24%), Positives = 94/223 (42%), Gaps = 31/223 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL----DTETEGVPSTAIREISLLKE 57 N Q + +G G +G V +A G+ A+ K+ + T + E+ ++ Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSH 105 Query: 58 LN-HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKS--------- 106 L H NIV LL + ++ E+ + DL F+ G+ S Sbjct: 106 LGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSS 165 Query: 107 -----YLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTH 161 + Q+ QG+AF S +HRD+ +N+L+ K+ DFGLAR + ++ Sbjct: 166 RDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLAR----DIMNDSN 221 Query: 162 EVVT------LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 +V + + APE + C Y+ D+WS G + E+ + Sbjct: 222 YIVKGNARLPVKWMAPESIFDC-VYTVQSDVWSYGILLWEIFS 263 >2PZI-A nrPDB Length = 681 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 111/223 (49%), Gaps = 24/223 (10%) Query: 10 IGEGTYGVVYKARNK-LTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 I G G +Y A ++ + G V LK + + + + A+ E L E+ HP+IV++ + Sbjct: 88 IAHGGLGWIYLALDRNVNGRPVVLKGL-VHSGDAEAQAMAMAERQFLAEVVHPSIVQIFN 146 Query: 69 VI-----HTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 + H + Y+V E++ Q LK+ S +P+ +YL ++L L++ HS Sbjct: 147 FVEHTDRHGDPVGYIVMEYVGGQSLKR----SKGQKLPVAEAIAYLLEILPALSYLHSIG 202 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182 +++ DLKP+N+++ TE +KL D G + ++ + T ++APEI+ + Sbjct: 203 LVYNDLKPENIML-TEEQLKLIDLGAVSR----INSFGYLYGTPGFQAPEIVRTGP--TV 255 Query: 183 AVDIWSLGCIFAEMV----TRRALF-PGDSEIDQLFRIFRTLG 220 A DI+++G A + TR + G E D + + + + G Sbjct: 256 ATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYG 298 >2QLU-A nrPDB Length = 314 Score = 57.4 bits (137), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 102/216 (47%), Gaps = 24/216 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + Q +E G +G V+KA +L + VA+K L + + REI + H N Sbjct: 16 SLQLLEIKARGRFGCVWKA--QLMNDFVAVKIFPLQDKQSW---QSEREIFSTPGMKHEN 70 Query: 63 IVKLLDV----IHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQ----LLQ 113 +++ + + E +L+L+ F + L ++ + +T L + + + L + Sbjct: 71 LLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHE 130 Query: 114 GLAFC----HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLW 167 + +C H + HRD K +N+L+ ++ LADFGLA F G P +V T Sbjct: 131 DVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRR 190 Query: 168 YRAPEILLGCKYYST----AVDIWSLGCIFAEMVTR 199 Y APE+L G + +D++++G + E+V+R Sbjct: 191 YMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSR 226 >3SOC-A nrPDB Length = 322 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 96/214 (44%), Gaps = 23/214 (10%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 Q +E G +G V+KA +L E VA+K + + E+ L + H NI Sbjct: 26 LQLLEVKARGRFGCVWKA--QLLNEYVAVKIFPIQDKQSWQNEY---EVYSLPGMKHENI 80 Query: 64 VKLLDV----IHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIK-------SYLFQL 111 ++ + + L+L+ F + L F+ A+ ++ L I +YL + Sbjct: 81 LQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHED 140 Query: 112 LQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYR 169 + GL H + HRD+K +N+L+ +ADFGLA F G +V T Y Sbjct: 141 IPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYM 200 Query: 170 APEILLGCKYYST----AVDIWSLGCIFAEMVTR 199 APE+L G + +D++++G + E+ +R Sbjct: 201 APEVLEGAINFQRDAFLRIDMYAMGLVLWELASR 234 >5WNO-A nrPDB Length = 330 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 49/200 (24%), Positives = 92/200 (46%), Gaps = 15/200 (7%) Query: 8 EKIGEGTYGVV-----YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 +K+G G +G V Y R K VA+K + D + + E + + L H N Sbjct: 28 KKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTD---QSQTDEMLEEATNMFRLRHDN 84 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKS--YLFQLLQGLAFCHS 120 ++K++ ++ L +V +++ L + L L + Y +Q+ G+ + Sbjct: 85 LLKIIGFCMHDDGLKIVT--IYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEK 142 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV--VTLWYRAPEILLGCK 178 RV+HRDL +N+L+ +++ DFGL++ + T + V + + A EI Sbjct: 143 QRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEI-FSKH 201 Query: 179 YYSTAVDIWSLGCIFAEMVT 198 Y+ A D+W+ G E++T Sbjct: 202 CYTHASDVWAFGVTCWEIIT 221 >5CEK-A nrPDB Length = 263 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 58/245 (23%), Positives = 97/245 (39%), Gaps = 56/245 (22%) Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 +H NI +++VI E K Y+ FE D+ ++ + + Q++ +A C Sbjct: 59 SHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSR--KRLREEEAARLFKQIVSAVAHC 116 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKL-------------ADFGLARAFGVPVRTYTHEVVT 165 H ++ DLK + + +TE +L D L+ G P Sbjct: 117 HQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPA--------- 167 Query: 166 LWYRAPEILLGCKYYS-TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDE 224 Y +PEIL YS A D+WSLG + ++ R F DS+ LF R Sbjct: 168 --YVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPF-HDSDPSALFSKIRR------ 218 Query: 225 VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284 G +P++ + R L+ +L +P++R++A L HP Sbjct: 219 ----GQFCIPEH------------------ISPKARCLIRSLLRREPSERLTAPEILLHP 256 Query: 285 FFQDV 289 +F+ V Sbjct: 257 WFESV 261 >6DC0-A nrPDB Length = 292 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/245 (23%), Positives = 97/245 (39%), Gaps = 56/245 (22%) Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 +H NI +++VI E K Y+ FE D+ ++ + + Q++ +A C Sbjct: 56 SHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSR--KRLREEEAARLFKQIVSAVAHC 113 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKL-------------ADFGLARAFGVPVRTYTHEVVT 165 H ++ DLK + + +TE +L D L+ G P Sbjct: 114 HQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPA--------- 164 Query: 166 LWYRAPEILLGCKYYS-TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDE 224 Y +PEIL YS A D+WSLG + ++ R F DS+ LF R Sbjct: 165 --YVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPF-HDSDPSALFSKIRR------ 215 Query: 225 VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284 G +P++ + R L+ +L +P++R++A L HP Sbjct: 216 ----GQFCIPEH------------------ISPKARCLIRSLLRREPSERLTAPEILLHP 253 Query: 285 FFQDV 289 +F+ V Sbjct: 254 WFESV 258 >2Y4I-B nrPDB Length = 319 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/235 (24%), Positives = 101/235 (42%), Gaps = 36/235 (15%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E + E IG+G +G VY R GEV A++ I ++ + E RE+ ++ H Sbjct: 33 EQLEIGELIGKGRFGQVYHGR--WHGEV-AIRLIDIERDNEDQLKAFKREVMAYRQTRHE 89 Query: 62 NIVKLLDVIHTENKLYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYLFQLLQ 113 N+V + + L ++ +D K +D + I ++K Sbjct: 90 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVK-------- 141 Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV---PVRTYTHEVVTLW--Y 168 G+ + H+ +LH+DLK +N+ + G + + DFGL GV R + W + Sbjct: 142 GMGYLHAKGILHKDLKSKNVFYDN-GKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCH 200 Query: 169 RAPEILLGCK--------YYSTAVDIWSLGCIFAEMVTRRALF---PGDSEIDQL 212 APEI+ +S D+++LG I+ E+ R F P ++ I Q+ Sbjct: 201 LAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQM 255 >4NFN-A nrPDB Length = 309 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 43/157 (27%), Positives = 76/157 (48%), Gaps = 11/157 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELNH 60 + ++ ++KIG G +G +Y+A + LT E VALK E+ P ++ E+++LK+L Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-----VESAQQPKQVLKMEVAVLKKLQG 75 Query: 61 PN-IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 + + + + E Y+V + ++L + L Q+L+ + H Sbjct: 76 KDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIH 135 Query: 120 SHRVLHRDLKPQNLLI----NTEGAIKLADFGLARAF 152 S LHRD+KP N + +T + DFGLAR + Sbjct: 136 SVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 172 >5WNL-A nrPDB Length = 342 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 56/224 (25%), Positives = 104/224 (46%), Gaps = 32/224 (14%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIRE---ISLLKELN 59 F EK+G G +G VYK R+ +A+K PS + + + LL+E Sbjct: 21 EFAGWEKVGSGGFGQVYKVRHVHWKTWLAIK---------CSPSLHVDDRERMELLEEAK 71 Query: 60 HPNIVKLLDVIH----TENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQG 114 + K ++ + + LV E++ L+K + + L P L + + G Sbjct: 72 KMEMAKFRYILPVYGICQEPVGLVMEYMETGSLEKLLASEPL---PWDLRFRIVHETAVG 128 Query: 115 LAF--CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV------TL 166 + F C S +LH +LKP N+L++ +K++DFGLA+ G+ +++H++ T+ Sbjct: 129 MNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGM---SHSHDLSMDGLFGTI 185 Query: 167 WYRAPE-ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209 Y PE I + + T D++S + ++T++ F + I Sbjct: 186 AYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNI 229 >4BTK-A nrPDB Length = 337 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 43/152 (28%), Positives = 73/152 (48%), Gaps = 11/152 (7%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELNHPN-IV 64 ++KIG G +G +Y+A + LT E VALK E+ P ++ E+++LK+L + + Sbjct: 61 LKKIGGGGFGEIYEAMDLLTRENVALK-----VESAQQPKQVLKMEVAVLKKLQGKDHVC 115 Query: 65 KLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 + + E Y+V + ++L + L Q+L+ + HS L Sbjct: 116 RFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFL 175 Query: 125 HRDLKPQNLLI----NTEGAIKLADFGLARAF 152 HRD+KP N + +T + DFGLAR + Sbjct: 176 HRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 207 >2CHL-A nrPDB Length = 351 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 67/253 (26%), Positives = 105/253 (41%), Gaps = 27/253 (10%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 NF+ +KIG G +G + +N T E VA I+L+ P + E K+L + Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHL-EYRFYKQLGSGD 86 Query: 63 IVKLLDVIHTENKLY-LVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 + + K +V E L L+ D T L + QL+ + + HS Sbjct: 87 GIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT-FSLKTVLMIAIQLISRMEYVHSK 145 Query: 122 RVLHRDLKPQNLLIN-----TEGAIKLADFGLARAF-------GVPVRTYTHEVVTLWYR 169 +++RD+KP+N LI T+ I + DF LA+ + +P R + T Y Sbjct: 146 NLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYM 205 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDS-EIDQLFRIFRTLG-----TPD 223 + LG K S D+ +LG +F M R P + D L ++ +G TP Sbjct: 206 SINTHLG-KEQSRRDDLEALGHMF--MYFLRGSLPWQGLKADTLKERYQKIGDTKRATPI 262 Query: 224 EVVWPGVTSMPDY 236 EV+ M Y Sbjct: 263 EVLCENFPEMATY 275 >2C47-A nrPDB Length = 313 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 70/266 (26%), Positives = 115/266 (43%), Gaps = 31/266 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 NF+ +KIG G +G + +N T E VA I+L+ P + E K+L+ Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVA---IKLEPIKSRAPQLHL-EYRFYKQLSATE 60 Query: 63 IVKLLDVIHTENKLY-LVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 V + K +V E L L+ D T L + QL+ + + H+ Sbjct: 61 GVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT-FTLKTVLMIAIQLITRMEYVHTK 119 Query: 122 RVLHRDLKPQNLLINTEG-----AIKLADFGLARAF-------GVPVRTYTHEVVTLWYR 169 +++RD+KP+N L+ G AI + DFGLA+ + +P R + T Y Sbjct: 120 SLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 179 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDS-EIDQLFRIFRTLG-----TPD 223 + LG K S D+ +LG +F M R P + D L ++ +G TP Sbjct: 180 SINTHLG-KEQSRRDDLEALGHMF--MYFLRGSLPWQGLKADTLKERYQKIGDTKRATPI 236 Query: 224 EVVWPGVTSMPDYKPSFPKWARQ-DF 248 EV+ + P+ ++ ++ R+ DF Sbjct: 237 EVL---CENFPEEMATYLRYVRRLDF 259 >4R7H-A nrPDB Length = 343 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 56/230 (24%), Positives = 96/230 (41%), Gaps = 38/230 (16%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL----DTETEGVPSTAIREISLLKE 57 N Q + +G G +G V +A G+ A+ K+ + T + E+ ++ Sbjct: 50 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSH 109 Query: 58 LN-HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALT------------------ 97 L H NIV LL + ++ E+ + DL F+ A Sbjct: 110 LGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKE 169 Query: 98 -GIPLPL--IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV 154 G PL L + + Q+ QG+AF S +HRD+ +N+L+ K+ DFGLAR Sbjct: 170 DGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLAR---- 225 Query: 155 PVRTYTHEVVT------LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 + ++ +V + + APE + Y+ D+WS G + E+ + Sbjct: 226 DIMNDSNYIVKGNARLPVKWMAPESIFDS-VYTVQSDVWSYGILLWEIFS 274 >3M42-A nrPDB Length = 299 Score = 52.4 bits (124), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 69/298 (23%), Positives = 119/298 (39%), Gaps = 74/298 (24%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISL-LKELNHPNIVKLLD 68 +G G G V + NK T E ALK + + P A RE+ L + P+IV+++D Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRASQCPHIVRIVD 78 Query: 69 VIHT----ENKLYLVFEFLH-----QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 V L +V E L ++ D + ++KS + + + + H Sbjct: 79 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS----IGEAIQYLH 134 Query: 120 SHRVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 S + HRD+KP+NLL ++ +KL DFG A+ G Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE----------------------TTG 172 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS---M 233 K Y + D+WSLG I ++ F + + + PG+ + M Sbjct: 173 EK-YDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------AISPGMKTRIRM 216 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 Y+ P+W+ + E+ + L+ +L +P +R++ + HP+ TK Sbjct: 217 GQYEFPNPEWSE---------VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 265 >3LMG-A nrPDB Length = 344 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 49/203 (24%), Positives = 95/203 (46%), Gaps = 11/203 (5%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALK---KIRLDTETEGVPSTAIREISLLKELN 59 +K++ +G G +G V+K GE + + K+ D + + L+ Sbjct: 32 ELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLD 91 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMD-ASALTGIPLP-LIKSYLFQLLQGLAF 117 H +IV+LL + + L LV ++L L +D G P L+ ++ Q+ +G+ + Sbjct: 92 HAHIVRLLGLC-PGSSLQLVTQYL--PLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYY 148 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT--YTHEVVTLWYRAPEILL 175 H ++HR+L +N+L+ + +++ADFG+A + Y+ + + A E + Sbjct: 149 LEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIH 208 Query: 176 GCKYYSTAVDIWSLGCIFAEMVT 198 KY + D+WS G E++T Sbjct: 209 FGKYTHQS-DVWSYGVTVWELMT 230 >5VC6-A nrPDB Length = 289 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 35/139 (25%), Positives = 67/139 (48%), Gaps = 8/139 (5%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NHPN 62 F ++EKIG G +G V+K +L G + A+K+ + A+RE+ L H + Sbjct: 13 FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH 72 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASA-----LTGIPLPLIKSYLFQLLQGLAF 117 +V+ ++ + + E+ + DA + ++ +K L Q+ +GL + Sbjct: 73 VVRYFSAWAEDDHMLIQNEYCNGG--SLADAISENYRIMSYFKEAELKDLLLQVGRGLRY 130 Query: 118 CHSHRVLHRDLKPQNLLIN 136 HS ++H D+KP N+ I+ Sbjct: 131 IHSMSLVHMDIKPSNIFIS 149 >5X1R-A nrPDB Length = 302 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 45/166 (27%), Positives = 65/166 (39%), Gaps = 19/166 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKK--------------IRLDTETEGVPSTA- 48 F+ E IGEG +G+VY+A + +A+K+ I L E G A Sbjct: 23 FEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAG 82 Query: 49 ----IREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLI 104 I+E LL +HP ++ +L Y+ +F K + A I I Sbjct: 83 LNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDEAWI 142 Query: 105 KSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLAR 150 + L L + H LHRD+ N+ I L DFG AR Sbjct: 143 RRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSAR 188 >5X18-A nrPDB Length = 295 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 86/203 (42%), Gaps = 27/203 (13%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH-PNIVKL 66 +KIGEG++GV+++ N + G VA+K TE + E K LN PNI Sbjct: 13 KKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRD----EYKTYKILNGTPNIPYA 68 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 LV + L L+ D + + Q++ + H+H +++R Sbjct: 69 YYFGQEGLHNILVIDLLGPSLEDLFDWCGRK-FSVKTVVQVAVQMITLIEDLHAHDLIYR 127 Query: 127 DLKPQNLLINTEGA-----IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY- 180 D+KP N LI G I L DFG+A+ + P +T H + YR + L G Y Sbjct: 128 DIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDP-KTKQH----IPYREKKSLSGTARYM 182 Query: 181 ----------STAVDIWSLGCIF 193 S D+ +LG +F Sbjct: 183 SINTHLGREQSRRDDMEALGHVF 205 >2CMW-A nrPDB Length = 310 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 84/202 (41%), Gaps = 24/202 (11%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN----I 63 +KIG G +G + +N T E VA I+L+ P + E K+L Sbjct: 6 KKIGCGNFGELRLGKNLYTNEYVA---IKLEPIKSRAPQLHL-EYRFYKQLGSAGEGLPQ 61 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 V N + V E L L+ D T L + QLL + + HS + Sbjct: 62 VYYFGPCGKYNAM--VLELLGPSLEDLFDLCDRT-FTLKTVLMIAIQLLSRMEYVHSKNL 118 Query: 124 LHRDLKPQNLLINTEG-----AIKLADFGLARAF-------GVPVRTYTHEVVTLWYRAP 171 ++RD+KP+N LI +G I + DFGLA+ + +P R + T Y + Sbjct: 119 IYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSI 178 Query: 172 EILLGCKYYSTAVDIWSLGCIF 193 LG K S D+ +LG +F Sbjct: 179 NTHLG-KEQSRRDDLEALGHMF 199 >5AR8-A nrPDB Length = 326 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 96/210 (45%), Gaps = 20/210 (9%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIR-----LDTETEGVPSTAIREISLLKELNHPNIV 64 + G G V AR+ VA+K + LD+E + V +RE +L + I+ Sbjct: 40 LSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDV----LREAEILHKARFSYIL 95 Query: 65 KLLDVIHTENKLYLVFEFL-HQDLKKFMD-ASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 +L + + L +V E++ + L + + + + PL L ++ G+ + H+ Sbjct: 96 PILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMT 155 Query: 123 --VLHRDLKPQNLLINTEGAIKLADFGLAR-----AFGVPVRTYTHEVVTLWYRAPEILL 175 +LH DLK QN+L++ E +K+ADFGL++ E T+ Y PE Sbjct: 156 PPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYE 215 Query: 176 GCKYYSTAV--DIWSLGCIFAEMVTRRALF 203 + ++ DI+S I E+++R+ F Sbjct: 216 PGQKSRASIKHDIYSYAVITWEVLSRKQPF 245 >4NT4-A nrPDB Length = 312 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 70/272 (25%), Positives = 116/272 (42%), Gaps = 37/272 (13%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL---- 58 NF+ +KIG G +G + +N E VA I+++ P + E K L Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVA---IKMEPMKSKAPQLHL-EYRFYKLLGSHA 68 Query: 59 -NHPNIVKLLDVIHTENKLY--LVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 N P+ + + + T Y +V E L L+ + A L + QLL + Sbjct: 69 DNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARK-FSLKTVLMIAKQLLHRI 127 Query: 116 AFCHSHRVLHRDLKPQNLLIN-----TEGAIKLADFGLARAF-------GVPVRTYTHEV 163 + HS +++RD+KP+N LI E I + DFGLA+ + +P R + Sbjct: 128 EYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLT 187 Query: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDS-EIDQLFRIFRTLG-- 220 T Y + +G + S D+ +LG +F M R P + D L ++ +G Sbjct: 188 GTARYMSINTHMG-REQSRRDDLEALGHMF--MYFLRGSLPWQGLKADTLKERYQKIGDT 244 Query: 221 ---TPDEVVWPGVTSMPDYKPSFPKWARQ-DF 248 TP EV+ G P+ ++ ++ R+ DF Sbjct: 245 KRATPIEVLCDG---HPEEFATYLRYVRRLDF 273 >5E8V-A nrPDB Length = 316 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 90/214 (42%), Gaps = 27/214 (12%) Query: 10 IGEGTYGVVYKARNKL-TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 +G+G + VYKA+ K T E +++ E ++I L H NI++ L Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLT 76 Query: 69 VIHTENKL---YLVFEFLHQ--DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR- 122 + +L Y + H +L++++ ++ L + S L +G+A HS Sbjct: 77 AEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGS---SLARGIAHLHSDHT 133 Query: 123 --------VLHRDLKPQNLLINTEGAIKLADFGLAR----AFGVPVRTYTHEVVTLWYRA 170 ++HRDLK N+L+ + L DFGL+ V + +V T Y A Sbjct: 134 PCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMA 193 Query: 171 PEILLGCKYYSTA-----VDIWSLGCIFAEMVTR 199 PE+L D++S+ + EM +R Sbjct: 194 PEVLASAMNLENVESFKQTDVYSMALVLWEMTSR 227 >3SV0-A nrPDB Length = 483 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/183 (28%), Positives = 83/183 (45%), Gaps = 14/183 (7%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTE-TEGVPSTAIREISLLKELNHPN 62 F+ KIG G++G +Y N T E VA+K + T+ + + + I I L PN Sbjct: 9 FRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIYRI-LQGGTGIPN 67 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 V+ V N LV + L L+ + + + L + Q++ + F HS Sbjct: 68 -VRWFGVEGDYN--VLVMDLLGPSLEDLFNFCSRK-LSLKTVLMLADQMINRVEFVHSKS 123 Query: 123 VLHRDLKPQNLLIN---TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 LHRD+KP N L+ + + DFGLA+ + T TH+ + YR + L G Sbjct: 124 FLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKY---RDTSTHQHIP--YRENKNLTGTAR 178 Query: 180 YST 182 Y++ Sbjct: 179 YAS 181 >4RT7-A nrPDB Length = 415 Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 31/124 (25%), Positives = 60/124 (48%), Gaps = 11/124 (8%) Query: 81 EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA 140 E +++ K+ + L + + + +Q+ +G+ F +HRDL +N+L+ Sbjct: 222 EIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKV 281 Query: 141 IKLADFGLARAFGVPVRTYTHEVVT------LWYRAPEILLGCKYYSTAVDIWSLGCIFA 194 +K+ DFGLAR + + ++ VV + + APE L Y+ D+WS G + Sbjct: 282 VKICDFGLAR----DIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILLW 336 Query: 195 EMVT 198 E+ + Sbjct: 337 EIFS 340 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 5/86 (5%) Query: 2 ENFQKVEKIGEGTYGVVYKARN---KLTGEVVALKKIRLDTETEGVPSTAI-REISLLKE 57 EN + + +G G +G V A TG + + L + + A+ E+ ++ + Sbjct: 65 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQ 124 Query: 58 L-NHPNIVKLLDVIHTENKLYLVFEF 82 L +H NIV LL +YL+FE+ Sbjct: 125 LGSHENIVNLLGACTLSGPIYLIFEY 150 >3AOX-A nrPDB Length = 344 Score = 48.1 bits (113), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 55/239 (23%), Positives = 99/239 (41%), Gaps = 27/239 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKAR-----NKLTGEVVALKKIRLDTETEGVPSTAIREISLLK 56 +N + +G G +G VY+ + N + VA+K + + +E + E ++ Sbjct: 47 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EVCSEQDELDFLMEALIIS 105 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQL---- 111 + NH NIV+ + V +++ E + DLK F+ + P P S L L Sbjct: 106 KFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETR----PRPSQPSSLAMLDLLH 161 Query: 112 -----LQGLAFCHSHRVLHRDLKPQNLLINTEG---AIKLADFGLARAF--GVPVRTYTH 161 G + + +HRD+ +N L+ G K+ DFG+AR R Sbjct: 162 VARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGC 221 Query: 162 EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLG 220 ++ + + PE + +++ D WS G + E+ + P S+ +Q F T G Sbjct: 222 AMLPVKWMPPEAFME-GIFTSKTDTWSFGVLLWEIFS-LGYMPYPSKSNQEVLEFVTSG 278 >3MY0-A nrPDB Length = 305 Score = 48.1 bits (113), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 63/222 (28%), Positives = 92/222 (41%), Gaps = 33/222 (14%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 VE +G+G YG V+ R GE VA+K E T I LL+ H NI+ Sbjct: 13 VECVGKGRYGEVW--RGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLR---HDNILGF 67 Query: 67 L--DVI--HTENKLYLVFEF-LHQDLKKFMDASALT-GIPLPLIKSYLFQLLQGLAFCHS 120 + D+ ++ +L+L+ + H L F+ L + L L S GLA H Sbjct: 68 IASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAAC----GLAHLHV 123 Query: 121 H--------RVLHRDLKPQNLLINTEGAIKLADFGLA--RAFGVPVRTYTHE--VVTLWY 168 + HRD K +N+L+ + +AD GLA + G + V T Y Sbjct: 124 EIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRY 183 Query: 169 RAPEIL-----LGCKYYSTAVDIWSLGCIFAEMVTRRALFPG 205 APE+L C DIW+ G + E + RR + G Sbjct: 184 MAPEVLDEQIRTDCFESYKWTDIWAFGLVLWE-IARRTIVNG 224 >4L00-A nrPDB Length = 304 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 67/307 (21%), Positives = 118/307 (38%), Gaps = 63/307 (20%) Query: 8 EKIGEGTYGVVYKAR------NKLTGEVVALKKIR--LDTETEGVPSTAIREISLLKELN 59 E +G GT +Y ++ T E +K I LD + S++++++ Sbjct: 31 EHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVS 90 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQ---DLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 H +IV L V + + +V EF+ DL + LT P QL L+ Sbjct: 91 HKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLT---TPWKFKVAKQLASALS 147 Query: 117 FCHSHRVLHRDLKPQNLLINTEGA-------IKLADFGLARAFGVPVRTYTHEVVTLWYR 169 + ++H ++ +NLL+ EG IKL+D G+ + V + + + + Sbjct: 148 YLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIP----ITVLSRQECIERIPWI 203 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 APE + K S A D WS G E+ + D + + R + + P V P Sbjct: 204 APECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRP---VTPS 260 Query: 230 VTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 + D L+++ ++YDPN+R PFF+ + Sbjct: 261 CKELAD--------------------------LMTRCMNYDPNQR---------PFFRAI 285 Query: 290 TKPVPHL 296 + + L Sbjct: 286 MRDINKL 292 >5M07-A nrPDB Length = 276 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 27/105 (25%), Positives = 55/105 (52%), Gaps = 5/105 (4%) Query: 50 REISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYL 108 RE + L HP+I+++ D + +L++ +++ D + M +P+ + + + Sbjct: 79 RETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIV 138 Query: 109 FQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLA 149 + L + H +LHRD+ P N+++ ++ A I LADFG+A Sbjct: 139 TAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIA 183 >4XHH-A nrPDB Length = 403 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 56/196 (28%), Positives = 86/196 (43%), Gaps = 40/196 (20%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVA--LKKIR-----LDTETE-------GVPSTAI 49 F+ KIG G++G +Y N ++GE VA L+ IR LD E+ GV I Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKYLSGGVGIPFI 68 Query: 50 REISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF 109 R E N ++ LL L +F + H +KF S T I L L Sbjct: 69 RWFGREGEYN-AMVIDLLGP-----SLEDLFNYCH---RKF---SFKTVIMLAL------ 110 Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTL 166 Q++ + + H +HRD+KP N L+ + + DFGL++ + T+ H + Sbjct: 111 QMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKY-RDFNTHRH----I 165 Query: 167 WYRAPEILLGCKYYST 182 YR + L G Y++ Sbjct: 166 PYRENKSLTGTARYAS 181 >4XHL-A nrPDB Length = 394 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 87/213 (40%), Gaps = 43/213 (20%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVA--LKKIR-----LDTETE-------GVPSTAI 49 F+ KIG G++G +Y N ++GE VA L+ IR LD E+ GV I Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSGGVGIPFI 68 Query: 50 REISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF 109 R E N ++ LL L +F + H+ S T I L L Sbjct: 69 RWFGREGEYN-AMVIDLLGP-----SLEDLFNYCHRRF------SFKTVIMLAL------ 110 Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAF-------GVPVRTY 159 Q+ + + H +HRD+KP N L+ + + DFGL++ + +P R Sbjct: 111 QMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYREN 170 Query: 160 THEVVTLWYRAPEILLGCKYYSTAVDIWSLGCI 192 T Y + LG + S D+ SLG + Sbjct: 171 KSLTGTARYASVNTHLGIE-QSRRDDLESLGYV 202 >5FQD-C nrPDB Length = 341 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 54/192 (28%), Positives = 82/192 (42%), Gaps = 32/192 (16%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 ++ V KIG G++G +Y A N GE VA+K + S R LL E I Sbjct: 21 YKLVRKIGSGSFGDIYLAINITNGEEVAVK----------LESQKARHPQLLYESKLYKI 70 Query: 64 VKLLDVI-----HTENKLY--LVFEFLH---QDLKKFMDASALTGIPLPLIKSYLFQLLQ 113 ++ I + + K Y LV + L +DL F L L Q++ Sbjct: 71 LQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLAD----QMIS 126 Query: 114 GLAFCHSHRVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 + + H+ +HRD+KP N L+ + L DFGLA+ + RT H + YR Sbjct: 127 RIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY-RDNRTRQH----IPYRE 181 Query: 171 PEILLGCKYYST 182 + L G Y++ Sbjct: 182 DKNLTGTARYAS 193 >1CSN-A nrPDB Length = 298 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 87/205 (42%), Gaps = 33/205 (16%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS--TAIREISLLKELNH-PNIVK 65 +IGEG++GV+++ N L + VA I+ + P R LL PN+ Sbjct: 17 RIGEGSFGVIFEGTNLLNNQQVA---IKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNVYY 73 Query: 66 L-LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 + +H LV + L L+ +D + + Q+L + H ++ Sbjct: 74 FGQEGLHN----VLVIDLLGPSLEDLLDLCGRK-FSVKTVAMAAKQMLARVQSIHEKSLV 128 Query: 125 HRDLKPQNLLI---NTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 +RD+KP N LI N++ A I + DFG+ + + PV T H + YR + L G Sbjct: 129 YRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPV-TKQH----IPYREKKNLSGTAR 183 Query: 180 Y-----------STAVDIWSLGCIF 193 Y S D+ +LG +F Sbjct: 184 YMSINTHLGREQSRRDDLEALGHVF 208 >4TN6-A nrPDB Length = 318 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 45/178 (25%), Positives = 76/178 (42%), Gaps = 14/178 (7%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 KIG G++G +Y + GE VA I+L+ P I E + K + + + Sbjct: 14 KIGSGSFGDIYLGTDIAAGEEVA---IKLECVKTKHPQLHI-ESKIYKMMQGGVGIPTIR 69 Query: 69 VIHTENKL-YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 E +V E L L+ + + L + Q++ + + HS +HRD Sbjct: 70 WCGAEGDYNVMVMELLGPSLEDLFNFCSRK-FSLKTVLLLADQMISRIEYIHSKNFIHRD 128 Query: 128 LKPQNLLIN---TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182 +KP N L+ + + DFGLA+ + RT+ H + YR + L G Y++ Sbjct: 129 VKPDNFLMGLGKKGNLVYIIDFGLAKKY-RDARTHQH----IPYRENKNLTGTARYAS 181 >4M69-B nrPDB Length = 283 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 37/166 (22%), Positives = 71/166 (42%), Gaps = 14/166 (8%) Query: 51 EISLLKELNHPNIVKLLDVIHTEN----KLYLVFEFLH-QDLKKFMDASALTGIPLPLIK 105 EI +K+ + PNI+++ + + + +V E+ L++ +D + + + Sbjct: 58 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREK--DLTMSVRS 115 Query: 106 SYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----TH 161 + + +GL H LHR++ + L+ +KLA F L++ RT Sbjct: 116 LLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAE 175 Query: 162 EVVTLWYRAPEILLG--CKYYSTAVDIWSLGCIFAEMVTRRALFPG 205 + Y +PE L C Y +I+S G + E+ T + F G Sbjct: 176 RSSSTIYVSPERLKNPFC-LYDIKAEIYSFGIVLWEIATGKIPFEG 220 >4IX6-A nrPDB Length = 350 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 90/214 (42%), Gaps = 43/214 (20%) Query: 101 LPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTE--GAIKLADFGLARAFGVP--- 155 L + K + +LL LA H V+HRD+KP NL+ + G +KL D G A A +P Sbjct: 142 LGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAA-ALCLPLPE 200 Query: 156 -VRTYTHE--VVTLWYRAPEILL------------GCKYYST----AVDIWSLGCIFAEM 196 + Y + + +A E+ L K + D WS GC+ ++ Sbjct: 201 TLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQL 260 Query: 197 VTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLD 256 D+ +++ ++ +G D + G S ++ DF+ LD Sbjct: 261 AV--VGLRTDAGLERFLADYKAVGY-DVNAFRGEKS--------GEYGTMDFAA----LD 305 Query: 257 EDGRS---LLSQMLHYDPNKRISAKAALAHPFFQ 287 +G + L +++ + + R S +AAL+H FF Sbjct: 306 ANGGAGWDLCQRLMEAERDARASCEAALSHAFFD 339 >4BTF-A nrPDB Length = 469 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 37/166 (22%), Positives = 71/166 (42%), Gaps = 14/166 (8%) Query: 51 EISLLKELNHPNIVKLLDVIHTEN----KLYLVFEFLH-QDLKKFMDASALTGIPLPLIK 105 EI +K+ + PNI+++ + + + +V E+ L++ +D + + + Sbjct: 244 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREK--DLTMSVRS 301 Query: 106 SYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----TH 161 + + +GL H LHR++ + L+ +KLA F L++ RT Sbjct: 302 LLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAE 361 Query: 162 EVVTLWYRAPEILLG--CKYYSTAVDIWSLGCIFAEMVTRRALFPG 205 + Y +PE L C Y +I+S G + E+ T + F G Sbjct: 362 RSSSTIYVSPERLKNPFC-LYDIKAEIYSFGIVLWEIATGKIPFEG 406 >5OAT-A nrPDB Length = 411 Score = 40.8 bits (94), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 84/200 (42%), Gaps = 39/200 (19%) Query: 60 HPNIVKLLDV------------IHTENK-----LYLVFEFLHQDLKKFMDASALTGIPLP 102 HPNIV + V +H E + L+L+ + +L+ F+ + T Sbjct: 98 HPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLLMKRYDCNLQSFLSTAPSTRTS-- 155 Query: 103 LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARA-----FG 153 L QLL+G+A +H + HRDLK NLL++T + ++DFG A Sbjct: 156 --LLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLS 213 Query: 154 VPVRTYTHEV-VTLWYRAPEIL------LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGD 206 +P +Y + APEI+ YS A D+W++G I E+ F G Sbjct: 214 LPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYSKA-DLWAVGAIAYEIFNCHNPFYGP 272 Query: 207 SEIDQL-FRIFRTLGTPDEV 225 S + ++ PDEV Sbjct: 273 SRLKNFNYKEGDLPKLPDEV 292 >4JRN-A nrPDB Length = 372 Score = 39.7 bits (91), Expect = 0.001, Method: Compositional matrix adjust. Identities = 59/243 (24%), Positives = 96/243 (39%), Gaps = 48/243 (19%) Query: 10 IGEGTYGVVYKARNKLTGEVVALK----------KIRLDTETEGVPSTAIREISLLKELN 59 +G G + VY+A + T E +A+K + LD + E S+ R SL K Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRE---SSCYRNFSLAKTAK 132 Query: 60 H---------PNIVKLLD--------VIHTENK----LYLVFEFLHQDLKK-----FMDA 93 P+ V +L+ VI + +L+ D+ K F DA Sbjct: 133 DAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDA 192 Query: 94 SALTGIPLPLIKSYLF-QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLAR-- 150 S +++ YL Q ++ +A + ++H D+KP N L+ +G + L DFG R Sbjct: 193 SVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRIN 252 Query: 151 -AFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209 + G + T +E ++A I Y+ D W LG + + P D Sbjct: 253 NSVGRAIGTPGYEPPERPFQATGIT-----YTFPTDAWQLGITLYCIWCKERPTPADGIW 307 Query: 210 DQL 212 D L Sbjct: 308 DYL 310 >5J0A-A nrPDB Length = 300 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/160 (23%), Positives = 68/160 (42%), Gaps = 10/160 (6%) Query: 49 IREISLLKELNHPNIVKLLDVIH-TENKLYLVFEFLHQ----DLKKFMDASALTGIPLPL 103 + E +LK L+HPNIV + L L E+ + DL + ++ P + Sbjct: 62 MDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAI 121 Query: 104 IKSYLFQLLQGLAFCHSH-RVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPVRTYTH 161 I + +GL + H ++LH D+K N++I + IK+ D G++ + Sbjct: 122 ILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDP 181 Query: 162 EVV---TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT 198 E T ++ E + + DI++ G EM+T Sbjct: 182 EACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMT 221 >5L2Q-C nrPDB Length = 320 Score = 38.5 bits (88), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/98 (28%), Positives = 46/98 (46%), Gaps = 4/98 (4%) Query: 119 HSHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 H ++HRDLK N+++N I + +F L + + + Y +P++L G Sbjct: 170 HQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGR 229 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFP-GDSEIDQLFR 214 Y D+W+LG + M+ FP DS +LFR Sbjct: 230 PYRGKPSDMWALGVVLFTMLY--GQFPFYDSIPQELFR 265 >3REP-A nrPDB Length = 271 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 46/217 (21%), Positives = 86/217 (39%), Gaps = 30/217 (13%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 K+ E G ++K R + VV + K+R D T E L+ +HPN++ +L Sbjct: 17 KLNENHSGELWKGRWQGNDIVVKVLKVR-DWSTRKS-RDFNEECPRLRIFSHPNVLPVLG 74 Query: 69 VIHTENKLY-----------LVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 + + ++ LH+ +D S + + +G+AF Sbjct: 75 ACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAV--------KFALDMARGMAF 126 Query: 118 CHSHRVL--HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 H+ L L ++++I+ + +++ + +F P R Y V APE L Sbjct: 127 LHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQSPGRMYAPAWV-----APEALQ 181 Query: 176 GCKYYST--AVDIWSLGCIFAEMVTRRALFPGDSEID 210 + + D+WS + E+VTR F S ++ Sbjct: 182 KKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNME 218 >4L68-A nrPDB Length = 340 Score = 38.1 bits (87), Expect = 0.004, Method: Compositional matrix adjust. Identities = 44/167 (26%), Positives = 76/167 (45%), Gaps = 32/167 (19%) Query: 51 EISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLF 109 E++ L EL H N+ LL E + +LV++++ L +D++ L S F Sbjct: 85 EMNQLWELRHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSN-----RGELDWSTRF 139 Query: 110 QL----LQGLAFCHSHR---VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT---- 158 ++ +GLA+ H +LH+++ +LI+ + ++ D GLAR VP Sbjct: 140 RIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLM-VPSDNNESS 198 Query: 159 -YTHEVVTLWYRAPEILLGCKYYSTAV------DIWSLGCIFAEMVT 198 T ++ Y APE YST + D++ LG + E+ T Sbjct: 199 FMTGDLGEFGYVAPE-------YSTTMLASLKGDVYGLGVVLLELAT 238 >4MWI-A nrPDB Length = 294 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 45/177 (25%), Positives = 73/177 (41%), Gaps = 20/177 (11%) Query: 44 VPSTAIREISLLKELNHPNIVKLLDVIHTEN----KLYLVFEFLH-QDLKKFMDASALTG 98 V T +EI +K+ PNI+++ + E + +V E+ L++ +D Sbjct: 66 VRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREK--- 122 Query: 99 IPLPLIKSYLFQL--LQGLAFCHSHRV--LHRDLKPQNLLINTEGAIKLADFGLAR---- 150 L L K + L +GL H LH ++ N L+ +KLA F L + Sbjct: 123 -DLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTS 181 Query: 151 -AFGVPVRTYTHEVVTLWYRAPEILLGCKY-YSTAVDIWSLGCIFAEMVTRRALFPG 205 + G R T V + Y +P+ L Y Y +I+S G + E+ T F G Sbjct: 182 MSLGT-TREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQG 237 >2RSV-A nrPDB Length = 403 Score = 37.4 bits (85), Expect = 0.007, Method: Compositional matrix adjust. Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 3/75 (4%) Query: 77 YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN 136 +++ + DL+K +A+A + ++L L + H H +H D+K NLL+N Sbjct: 135 FMIMDRFGSDLQKIYEANAKR-FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 193 Query: 137 TEG--AIKLADFGLA 149 + + L D+GLA Sbjct: 194 YKNPDQVYLVDYGLA 208 >2LAV-A nrPDB Length = 361 Score = 37.0 bits (84), Expect = 0.010, Method: Compositional matrix adjust. Identities = 21/78 (26%), Positives = 39/78 (50%), Gaps = 3/78 (3%) Query: 77 YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN 136 +++ + DL+K +A+A + ++L L + H H +H D+K NLL+N Sbjct: 128 FMIMDRFGSDLQKIYEANAKR-FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLN 186 Query: 137 TEG--AIKLADFGLARAF 152 + + L D+GLA + Sbjct: 187 YKNPDQVYLVDYGLAYRY 204 >5UU1-A nrPDB Length = 324 Score = 35.0 bits (79), Expect = 0.038, Method: Compositional matrix adjust. Identities = 46/176 (26%), Positives = 76/176 (43%), Gaps = 30/176 (17%) Query: 1 MENFQKV--EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEG------------VPS 46 ME Q V +KIG G +G++Y A E A ++++ + G Sbjct: 13 MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKK 72 Query: 47 TAIREISLLKELNHPNIVKLLDVIHTENK----LYLVFEFLHQDLKKFMDASALTGIPLP 102 I++ K+L++ I TE K ++V E L DL+K ++G Sbjct: 73 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQK------ISGQNGT 126 Query: 103 LIKSYLFQL----LQGLAFCHSHRVLHRDLKPQNLLINTEG--AIKLADFGLARAF 152 KS + QL L L + H + +H D+K NLL+ + + LAD+GL+ + Sbjct: 127 FKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRY 182 >4OAU-C nrPDB Length = 699 Score = 35.0 bits (79), Expect = 0.044, Method: Compositional matrix adjust. Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 10/121 (8%) Query: 33 KKIRLDTETEGVPSTAIREISLLKE-LNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFM 91 +++ + T EG P A RE+S L+ + ++V L++ Q L+ + Sbjct: 367 QEVAVKTFCEGSPR-AQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACL 425 Query: 92 DASALTGIP------LPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLAD 145 D + + S +F+ +Q L S H+DL+PQN+LI+++ A LAD Sbjct: 426 DVHRGEDVENEEDEFARNVLSSIFKAVQELHL--SCGYTHQDLQPQNILIDSKKAAHLAD 483 Query: 146 F 146 F Sbjct: 484 F 484 >4O1O-A nrPDB Length = 717 Score = 34.3 bits (77), Expect = 0.065, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 25/42 (59%) Query: 105 KSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADF 146 ++ L L + + H H+DL+PQN+LI+++ LADF Sbjct: 445 RNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF 486 >6G4J-A nrPDB Length = 315 Score = 33.9 bits (76), Expect = 0.093, Method: Compositional matrix adjust. Identities = 38/166 (22%), Positives = 69/166 (41%), Gaps = 26/166 (15%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 +++G+G G+VY A G V +++ ++ + S E+++LK + V + Sbjct: 32 KQLGKGANGIVYLAETS-DGHVA----LKVSDDSLSITS----EVNVLKSFSKAQSVTMG 82 Query: 68 DVIHTENKLYL----------VFEFLHQDLK-KFMDASALTGIPLPLIKSYLFQLLQGLA 116 + Y+ E++ L K++ IP+ +I QLL L+ Sbjct: 83 PSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMI-----QLLSSLS 137 Query: 117 FCHSHRVLHRDLKPQNLLINTEGA-IKLADFGLARAFGVPVRTYTH 161 H + DLKP NL++ A I+ D G G ++ YT Sbjct: 138 VLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTE 183 >5UV4-A nrPDB Length = 311 Score = 33.1 bits (74), Expect = 0.13, Method: Compositional matrix adjust. Identities = 50/208 (24%), Positives = 87/208 (41%), Gaps = 21/208 (10%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTA---IREISLLKELNHPNI 63 E IG +G YKA G ++ +K ++ EG + REI L + HPN+ Sbjct: 30 AEIIGRSCHGTSYKATLD-NGYMLTVKWLK-----EGFAKSKKEFSREIKKLGSVRHPNL 83 Query: 64 VKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC-- 118 V L E++ ++ ++ L ++ +P PL + +A C Sbjct: 84 VPLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLP-PLSAGQRLNIAIDIARCLD 142 Query: 119 --HSHRVL-HRDLKPQNLLI-NTEGAIKLADFGLARAFG-VPVRTYTHEVVTLWYRAPEI 173 H+ RV+ H ++K N+LI N+ + + D+ L R + + L Y PE Sbjct: 143 YLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEF 202 Query: 174 LLGCK-YYSTAVDIWSLGCIFAEMVTRR 200 K S D+++ G I E++T + Sbjct: 203 SSTSKPCPSLKSDVYAFGVILLELLTGK 230 >5C01-A nrPDB Length = 342 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 12/96 (12%) Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLI-------NTEGAIKLADFGLARAFGVPVRTYTHE 162 QL L++ + ++H ++ +N+L+ T IKL+D G+ G+ + Sbjct: 188 QLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGV----GLGALSREER 243 Query: 163 VVTLWYRAPEIL-LGCKYYSTAVDIWSLGCIFAEMV 197 V + + APE L G STA+D W G E+ Sbjct: 244 VERIPWLAPECLPGGANSLSTAMDKWGFGATLLEIC 279 >4WOV-A nrPDB Length = 317 Score = 32.7 bits (73), Expect = 0.19, Method: Compositional matrix adjust. Identities = 43/180 (23%), Positives = 73/180 (40%), Gaps = 41/180 (22%) Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLI-------NTEGAIKLADFGLARAFGVPVRTYTHE 162 QL L++ + ++H ++ +N+L+ T IKL+D G+ G+ + Sbjct: 165 QLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGV----GLGALSREER 220 Query: 163 VVTLWYRAPEIL-LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGT 221 V + + APE L G STA+D W G E+ F G++ + + Sbjct: 221 VERIPWLAPECLPGGANSLSTAMDKWGFGATLLEIC-----FDGEAPLQS------RSPS 269 Query: 222 PDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281 E + +P+ PS P+ A +L SQ L Y+P +R S + L Sbjct: 270 EKEHFYQRQHRLPE--PSCPQLA----------------TLTSQCLTYEPTQRPSFRTIL 311 >4CYJ-A nrPDB Length = 438 Score = 32.7 bits (73), Expect = 0.22, Method: Compositional matrix adjust. Identities = 36/159 (22%), Positives = 65/159 (40%), Gaps = 23/159 (14%) Query: 18 VYKARNKLTGEVVALKKI---RLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTE- 73 VYKA+N G AL+++ RL E + + K++ + +IV + +V T Sbjct: 71 VYKAQNSRNGRHYALRRLEGYRLTNE-----KAILNVMKDWKKIKNASIVTIHEVFTTRE 125 Query: 74 -NKLYLVFEFLHQDLKKFMDASALT-----------GIPLPLIKSYLFQLLQGLAFCHSH 121 L+F + L K + +P I Y+ Q+ L HS+ Sbjct: 126 FGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSN 185 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARA--FGVPVRT 158 R+ R L+P +++ I+L+ + FG+ R+ Sbjct: 186 RLAARCLEPSKIILTDINRIRLSACAILDVVQFGMNSRS 224 >5CLR-A nrPDB Length = 451 Score = 32.3 bits (72), Expect = 0.26, Method: Compositional matrix adjust. Identities = 19/69 (27%), Positives = 38/69 (55%), Gaps = 12/69 (17%) Query: 86 DLKKFMDASALTGIPLPLIKSYLFQLLQ-GLAFCHSHR------VLHRDLKPQNLLINTE 138 DL ++ +A +PL + + +++L ++ CH + ++HRDLKP N++++ + Sbjct: 158 DLSRYKNA-----LPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIMLDAD 212 Query: 139 GAIKLADFG 147 L DFG Sbjct: 213 MQCHLVDFG 221 >6J6I-B nrPDB Length = 351 Score = 32.3 bits (72), Expect = 0.28, Method: Compositional matrix adjust. Identities = 40/184 (21%), Positives = 73/184 (39%), Gaps = 15/184 (8%) Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG----IPLPLIKSYLFQLLQG 114 NH N ++LL LVFEF + G +P + ++ Sbjct: 116 NHSNFLQLLGCCLEFPFPVLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANA 175 Query: 115 LAFCHS---HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--TLWYR 169 + + H+ ++HRD+KP ++ ++ KL+D + + E V T Y Sbjct: 176 VTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYI 235 Query: 170 APEILLGCKYYSTAVDIWSLG-CIFAEMVTRRALFP-GDSEIDQLFRIFRTL---GTPDE 224 P C + + D++S G C+ + + A+ D ++ + + R L G DE Sbjct: 236 DPLYHKTC-FVTEYTDVYSFGICLLVIITGKPAIMTISDGDLQGILSLVRELCENGKLDE 294 Query: 225 VVWP 228 V+ P Sbjct: 295 VIDP 298 >5KH2-A nrPDB Length = 272 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 28/114 (24%), Positives = 51/114 (44%), Gaps = 12/114 (10%) Query: 34 KIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDA 93 KI++ ET+ +P ++ +EL N +L+ + + L + +DA Sbjct: 128 KIQMIGETDRLPKQTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLISQDVLDA 187 Query: 94 SALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADF 146 G I LI +YLF + L +DL+ +L+I T G ++L++F Sbjct: 188 KINPGDITEELIGNYLFT-----------QHLPKDLRDPDLIIRTSGELRLSNF 230 >6EQI-C nrPDB Length = 433 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 24/42 (57%), Gaps = 5/42 (11%) Query: 113 QGLAFCHSHRVLHRDLKPQNLLIN-TEG----AIKLADFGLA 149 + +A + H + HRDLK N+L++ +EG I + DFG Sbjct: 178 EAVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCC 219 >4BWP-A nrPDB Length = 448 Score = 29.3 bits (64), Expect = 2.3, Method: Compositional matrix adjust. Identities = 20/74 (27%), Positives = 37/74 (50%), Gaps = 13/74 (17%) Query: 16 GVVYKARNKLTGEVVALKKI---RLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHT 72 Y+A + TG L++I RL + + + + + K+L H N+V+L +V T Sbjct: 64 ATTYRATHNTTGYKYCLRRIHGFRLQS------TKCMTLVEMWKKLQHTNVVQLREVFTT 117 Query: 73 ----ENKLYLVFEF 82 +N L LV+++ Sbjct: 118 KAFGDNSLVLVYDY 131 >5VE6-A nrPDB Length = 492 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 20/60 (33%), Positives = 27/60 (45%), Gaps = 5/60 (8%) Query: 81 EFLHQDLKKFMDASALTGIPLP-----LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLI 135 E HQ F+ SA + P + L QL GL H ++HRDL +NLL+ Sbjct: 182 EVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 >6EWX-A nrPDB Length = 484 Score = 28.9 bits (63), Expect = 2.7, Method: Compositional matrix adjust. Identities = 13/28 (46%), Positives = 17/28 (60%) Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLI 135 L QL GL H ++HRDL +NLL+ Sbjct: 216 LLQLCNGLEHLKEHGIIHRDLCLENLLL 243 >4AZV-A nrPDB Length = 569 Score = 28.9 bits (63), Expect = 2.8, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 21/40 (52%) Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFG 147 L LL+ LA H D++P N++++ +L DFG Sbjct: 345 LGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDFG 384 >5ZBY-A nrPDB Length = 158 Score = 28.5 bits (62), Expect = 3.6, Method: Compositional matrix adjust. Identities = 27/99 (27%), Positives = 50/99 (50%), Gaps = 12/99 (12%) Query: 11 GEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVI 70 G+ +GV+ R K E+V + + E +P + + +I+ K P++V +D I Sbjct: 25 GDDAFGVLVAERLK---ELVKTPDVLILNCGE-MPESYVGKIAAFK----PDLVVFVDAI 76 Query: 71 HTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYL 108 H + + EF+ D LK +A + G+PL ++ SY+ Sbjct: 77 HFGGE---IGEFIIADPLKTLGEAVSTHGLPLRIVASYI 112 >1T6J-A nrPDB Length = 716 Score = 28.5 bits (62), Expect = 3.7, Method: Compositional matrix adjust. Identities = 15/34 (44%), Positives = 18/34 (52%) Query: 261 SLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 SLLSQ L + + A HPF DVT+P P Sbjct: 290 SLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHP 323 >4AZW-A nrPDB Length = 471 Score = 28.5 bits (62), Expect = 4.0, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 21/40 (52%) Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFG 147 L LL+ LA H D++P N++++ +L DFG Sbjct: 345 LGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG 384 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2BPM-A nrPDB 452 e-127 6GU6-A nrPDB 377 e-105 3NIZ-A nrPDB 364 e-101 1V0B-A nrPDB 357 2e-99 4AU8-A nrPDB 353 4e-98 4KRC-A nrPDB 351 2e-97 1UA2-A nrPDB 332 1e-91 3GC0-A nrPDB 325 2e-89 5G6V-A nrPDB 322 1e-88 1G3N-A nrPDB 318 1e-87 5EFQ-A nrPDB 310 4e-85 1CM8-A nrPDB 307 3e-84 4NST-A nrPDB 307 4e-84 4EWQ-A nrPDB 307 5e-84 4BBM-A nrPDB 305 1e-83 3OHT-A nrPDB 305 2e-83 4MYG-A nrPDB 305 2e-83 2F9G-A nrPDB 305 2e-83 4AGU-A nrPDB 304 3e-83 4QTB-A nrPDB 304 4e-83 4IC8-A nrPDB 304 4e-83 2W96-B nrPDB 302 1e-82 5NGU-A nrPDB 299 8e-82 6DTL-A nrPDB 299 8e-82 4ZSG-A nrPDB 299 1e-81 5Z33-A nrPDB 298 2e-81 3GC9-A nrPDB 298 2e-81 3MIA-A nrPDB 294 5e-80 3NCG-A nrPDB 293 6e-80 4MVF-A nrPDB 293 8e-80 3OZ6-A nrPDB 291 3e-79 5JN2-A nrPDB 290 3e-79 4BGQ-A nrPDB 287 3e-78 3DFA-A nrPDB 287 4e-78 1JNK-A nrPDB 286 9e-78 4QNY-A nrPDB 285 1e-77 3LIJ-A nrPDB 284 2e-77 3MA6-A nrPDB 284 3e-77 2XS0-A nrPDB 284 4e-77 5AWM-A nrPDB 283 7e-77 3HZT-A nrPDB 282 9e-77 3FI2-A nrPDB 282 2e-76 3E7O-A nrPDB 281 2e-76 3ZDU-A nrPDB 280 4e-76 3DXN-A nrPDB 280 4e-76 5AIR-A nrPDB 280 4e-76 5FG8-A nrPDB 277 4e-75 3RP9-A nrPDB 277 6e-75 2VN9-A nrPDB 276 9e-75 2BDW-A nrPDB 272 1e-73 5U6Y-A nrPDB 272 1e-73 2V7O-A nrPDB 272 2e-73 4E7W-A nrPDB 272 2e-73 3N9X-A nrPDB 270 4e-73 3COM-A nrPDB 270 4e-73 2VZ6-A nrPDB 270 7e-73 3KK8-A nrPDB 269 1e-72 3NIE-A nrPDB 268 1e-72 3MN3-A nrPDB 268 2e-72 4O2Z-A nrPDB 268 2e-72 3BHH-A nrPDB 268 2e-72 5ES1-A nrPDB 268 2e-72 4LG4-A nrPDB 268 3e-72 3Q5I-A nrPDB 268 3e-72 4YZB-A nrPDB 267 6e-72 4RGJ-A nrPDB 265 1e-71 6AO5-A nrPDB 265 1e-71 3SOA-A nrPDB 265 2e-71 2JC6-A nrPDB 264 2e-71 4UZD-A nrPDB 264 3e-71 3PG1-A nrPDB 264 3e-71 2QNJ-A nrPDB 263 4e-71 5Y86-A nrPDB 263 8e-71 5IG1-A nrPDB 262 1e-70 5XZW-A nrPDB 262 1e-70 6FD3-A nrPDB 262 1e-70 3E3P-A nrPDB 262 1e-70 5YKS-A nrPDB 262 2e-70 3D2K-A nrPDB 262 2e-70 4FG9-A nrPDB 262 2e-70 5KZ7-A nrPDB 261 2e-70 3H4J-B nrPDB 260 5e-70 4JXF-A nrPDB 258 2e-69 3TAC-A nrPDB 258 3e-69 4REW-A nrPDB 257 5e-69 5WAX-A nrPDB 256 7e-69 4D28-A nrPDB 256 8e-69 4CFF-A nrPDB 255 2e-68 2I6L-A nrPDB 255 2e-68 4FIE-A nrPDB 255 2e-68 3DAK-A nrPDB 254 3e-68 5EZV-A nrPDB 254 3e-68 4CZT-A nrPDB 254 3e-68 2UV2-A nrPDB 254 3e-68 4PDS-A nrPDB 254 4e-68 2F57-A nrPDB 253 4e-68 5KCV-A nrPDB 253 7e-68 4L42-A nrPDB 253 7e-68 5ZTN-A nrPDB 253 9e-68 2J90-A nrPDB 253 9e-68 3EB0-A nrPDB 253 9e-68 6CMJ-A nrPDB 252 1e-67 2JDO-A nrPDB 252 1e-67 4JDH-A nrPDB 252 1e-67 3Q53-A nrPDB 252 2e-67 4KS7-A nrPDB 252 2e-67 4XBR-A nrPDB 252 2e-67 2JAM-A nrPDB 252 2e-67 2Q0N-A nrPDB 251 2e-67 4CQG-A nrPDB 251 3e-67 3MV5-A nrPDB 251 3e-67 4CFH-A nrPDB 251 3e-67 1PHK-A nrPDB 251 3e-67 1FOT-A nrPDB 251 3e-67 4RED-A nrPDB 251 3e-67 4NIF-A nrPDB 250 4e-67 5D9K-A nrPDB 250 4e-67 4RLP-A nrPDB 250 5e-67 2YAB-A nrPDB 250 6e-67 2XIK-A nrPDB 250 6e-67 2Y7J-A nrPDB 250 6e-67 4D2V-A nrPDB 250 6e-67 3IS5-A nrPDB 250 8e-67 4QMW-A nrPDB 249 9e-67 5J5T-A nrPDB 249 1e-66 2W4O-A nrPDB 248 1e-66 5DBX-A nrPDB 248 2e-66 3F3Z-A nrPDB 248 2e-66 6HXF-B nrPDB 248 2e-66 4APC-A nrPDB 248 2e-66 3TXO-A nrPDB 248 2e-66 6C9D-A nrPDB 248 2e-66 3ZUT-A nrPDB 248 3e-66 2YZA-A nrPDB 247 3e-66 2HAK-A nrPDB 247 3e-66 2YCR-A nrPDB 247 4e-66 4CSV-A nrPDB 247 5e-66 4FZF-B nrPDB 247 5e-66 6FDY-U nrPDB 247 6e-66 5D7A-A nrPDB 247 6e-66 3UTO-A nrPDB 246 8e-66 5F9E-A nrPDB 246 9e-66 3UDB-A nrPDB 246 1e-65 2Z7Q-A nrPDB 245 1e-65 2A27-A nrPDB 245 1e-65 3GUB-A nrPDB 245 2e-65 5YV8-A nrPDB 245 2e-65 1ZWS-A nrPDB 245 2e-65 3UC3-A nrPDB 244 3e-65 1KOA-A nrPDB 244 3e-65 3I6U-A nrPDB 243 5e-65 5JZN-A nrPDB 243 5e-65 4JG6-A nrPDB 243 5e-65 6E9W-A nrPDB 243 7e-65 6ED6-A nrPDB 243 9e-65 3DB8-A nrPDB 242 1e-64 3HDN-A nrPDB 242 1e-64 2X4F-A nrPDB 241 3e-64 1VZO-A nrPDB 240 8e-64 3TKU-A nrPDB 239 1e-63 2HW6-A nrPDB 239 1e-63 5X8I-B nrPDB 239 1e-63 4B6L-A nrPDB 238 2e-63 4B8L-A nrPDB 237 3e-63 1KOB-A nrPDB 237 3e-63 3HKO-A nrPDB 237 3e-63 4RA4-A nrPDB 237 5e-63 4CRL-A nrPDB 236 9e-63 4AW2-A nrPDB 236 1e-62 5LOH-A nrPDB 235 1e-62 2WQN-A nrPDB 235 2e-62 4I6B-A nrPDB 235 2e-62 3NYO-A nrPDB 235 2e-62 3KN6-A nrPDB 235 2e-62 3ORZ-A nrPDB 234 3e-62 4YNZ-A nrPDB 234 4e-62 2OU7-A nrPDB 233 6e-62 3A8W-A nrPDB 233 7e-62 2WO6-A nrPDB 233 8e-62 1U5R-A nrPDB 233 1e-61 5X3F-B nrPDB 232 1e-61 4U41-A nrPDB 232 1e-61 4TNB-A nrPDB 232 2e-61 4AF3-A nrPDB 232 2e-61 4J52-A nrPDB 232 2e-61 2GCD-A nrPDB 231 3e-61 5N23-A nrPDB 231 3e-61 4WB7-A nrPDB 231 3e-61 5DYK-A nrPDB 230 5e-61 6FYV-A nrPDB 230 8e-61 3PFQ-A nrPDB 228 3e-60 6CQF-A nrPDB 227 4e-60 6CKI-A nrPDB 227 4e-60 6E2O-A nrPDB 227 4e-60 3ALO-A nrPDB 227 6e-60 2VD5-A nrPDB 226 1e-59 3LM0-A nrPDB 225 1e-59 3VN9-A nrPDB 225 2e-59 2I0E-A nrPDB 225 2e-59 3C51-A nrPDB 225 2e-59 1NY3-A nrPDB 225 2e-59 5FET-A nrPDB 225 2e-59 3KA0-A nrPDB 225 2e-59 3PPZ-A nrPDB 225 3e-59 2FO0-A nrPDB 225 3e-59 2BRG-A nrPDB 225 3e-59 4XEY-B nrPDB 224 3e-59 2OZA-A nrPDB 224 4e-59 4WNO-A nrPDB 223 5e-59 3FXW-A nrPDB 223 7e-59 2XYN-A nrPDB 223 7e-59 6O6Q-A nrPDB 223 1e-58 6GVJ-A nrPDB 222 2e-58 4C0T-A nrPDB 222 2e-58 6NPU-A nrPDB 222 2e-58 6BDL-A nrPDB 222 2e-58 2H8H-A nrPDB 222 2e-58 3FME-A nrPDB 221 2e-58 6F3F-A nrPDB 221 3e-58 6CCF-A nrPDB 221 4e-58 5MJB-A nrPDB 221 4e-58 5UNP-A nrPDB 220 4e-58 4FR4-A nrPDB 220 5e-58 4P5Q-A nrPDB 220 5e-58 5KKR-C nrPDB 220 5e-58 6FEX-A nrPDB 220 9e-58 4E93-A nrPDB 220 9e-58 5H2U-A nrPDB 219 1e-57 6BSD-A nrPDB 219 1e-57 2WTK-C nrPDB 219 1e-57 2PVN-A nrPDB 218 2e-57 6QAU-A nrPDB 218 2e-57 2DQ7-X nrPDB 218 2e-57 4MD7-E nrPDB 218 2e-57 3A4O-X nrPDB 218 3e-57 2XNP-A nrPDB 218 3e-57 5L6P-A nrPDB 217 4e-57 3EQC-A nrPDB 217 4e-57 4YHJ-A nrPDB 217 4e-57 3HMP-A nrPDB 216 6e-57 2R2P-A nrPDB 216 6e-57 5SYS-A nrPDB 216 7e-57 6HMD-A nrPDB 216 9e-57 5UUU-A nrPDB 215 2e-56 1JPA-A nrPDB 215 2e-56 6BXI-A nrPDB 215 2e-56 3DKO-A nrPDB 215 2e-56 4AN9-A nrPDB 215 3e-56 3PVW-A nrPDB 214 3e-56 2ZMD-A nrPDB 214 3e-56 4OTD-A nrPDB 214 3e-56 5X5O-A nrPDB 214 4e-56 2Y6O-A nrPDB 214 4e-56 3RAW-A nrPDB 214 5e-56 5AP3-A nrPDB 213 5e-56 5XVU-A nrPDB 213 6e-56 4GS6-A nrPDB 213 8e-56 4EBW-A nrPDB 212 1e-55 6EII-A nrPDB 212 2e-55 2HK5-A nrPDB 211 2e-55 2PL0-A nrPDB 211 2e-55 5A46-A nrPDB 211 2e-55 2VWV-A nrPDB 211 3e-55 4YFF-A nrPDB 211 4e-55 1S9I-A nrPDB 210 7e-55 4UYA-A nrPDB 210 8e-55 2J0K-A nrPDB 209 1e-54 3GQL-A nrPDB 209 1e-54 4EQM-A nrPDB 209 1e-54 4AT3-A nrPDB 208 2e-54 1AD5-A nrPDB 208 2e-54 6FER-A nrPDB 208 2e-54 1TKI-A nrPDB 208 2e-54 3V5Q-A nrPDB 208 3e-54 3TT0-A nrPDB 208 3e-54 4CRS-A nrPDB 207 4e-54 1K9A-A nrPDB 207 5e-54 6GQK-A nrPDB 207 5e-54 4OLI-A nrPDB 207 6e-54 4XLV-A nrPDB 207 6e-54 4KIK-B nrPDB 206 7e-54 3QGY-A nrPDB 206 8e-54 5AMN-A nrPDB 206 1e-53 4UY9-A nrPDB 206 1e-53 5B2L-A nrPDB 205 2e-53 4PDO-A nrPDB 205 2e-53 4PWN-A nrPDB 205 2e-53 5O2B-A nrPDB 205 2e-53 2PSQ-A nrPDB 205 2e-53 5O2C-A nrPDB 205 2e-53 4XCU-A nrPDB 205 2e-53 1BYG-A nrPDB 205 2e-53 5EG3-A nrPDB 205 2e-53 6DBM-A nrPDB 205 3e-53 1FVR-A nrPDB 205 3e-53 5VO2-A nrPDB 205 3e-53 3OMV-A nrPDB 204 3e-53 4IAN-A nrPDB 204 3e-53 3DTC-A nrPDB 204 3e-53 3BBT-B nrPDB 204 4e-53 4Y93-A nrPDB 204 5e-53 2WTK-B nrPDB 204 5e-53 5HI2-A nrPDB 204 5e-53 2OGV-A nrPDB 203 5e-53 4XI2-A nrPDB 203 8e-53 1LUF-A nrPDB 203 9e-53 4K33-A nrPDB 203 1e-52 5VD3-A nrPDB 202 1e-52 4E20-A nrPDB 202 1e-52 3BEA-A nrPDB 202 1e-52 3SXS-A nrPDB 202 1e-52 3ORP-A nrPDB 202 2e-52 3KRL-A nrPDB 202 2e-52 5KMM-A nrPDB 202 2e-52 2JD5-A nrPDB 201 2e-52 1ZXE-A nrPDB 201 2e-52 5FM2-A nrPDB 201 3e-52 3KUL-B nrPDB 201 3e-52 6E4F-A nrPDB 201 3e-52 6DBN-A nrPDB 201 3e-52 4XUF-A nrPDB 200 7e-52 5X02-A nrPDB 200 9e-52 5HIE-A nrPDB 199 1e-51 3QA8-A nrPDB 199 1e-51 5GNK-A nrPDB 199 1e-51 4H1J-A nrPDB 199 2e-51 4R7H-A nrPDB 198 2e-51 3DLS-A nrPDB 198 2e-51 5O0Y-A nrPDB 198 3e-51 3CJF-A nrPDB 198 3e-51 3ZBF-A nrPDB 198 3e-51 3LZB-A nrPDB 198 4e-51 4M7I-A nrPDB 197 5e-51 5TUR-A nrPDB 196 6e-51 2X7G-A nrPDB 196 9e-51 3PP0-A nrPDB 196 9e-51 4HZS-A nrPDB 196 1e-50 2W1I-A nrPDB 195 1e-50 5HVK-A nrPDB 195 2e-50 5GRN-A nrPDB 195 2e-50 4LFI-A nrPDB 195 2e-50 3BGP-A nrPDB 195 2e-50 5U6B-A nrPDB 195 2e-50 3M42-A nrPDB 195 2e-50 3IO7-A nrPDB 195 3e-50 1U59-A nrPDB 195 3e-50 4RC3-A nrPDB 194 3e-50 2OZO-A nrPDB 194 4e-50 1U54-B nrPDB 194 4e-50 4WUA-A nrPDB 194 4e-50 2A1A-B nrPDB 194 5e-50 4LRM-A nrPDB 193 6e-50 3C1X-A nrPDB 193 6e-50 5HLW-A nrPDB 193 7e-50 5TQX-A nrPDB 193 9e-50 4HVI-A nrPDB 193 1e-49 3I81-A nrPDB 192 2e-49 3G0E-A nrPDB 191 2e-49 5UIU-A nrPDB 191 2e-49 2RIO-A nrPDB 191 2e-49 3QUP-A nrPDB 191 4e-49 5TOS-A nrPDB 190 5e-49 4TPT-A nrPDB 190 9e-49 3UIU-A nrPDB 189 1e-48 5U6C-A nrPDB 189 1e-48 3LLT-A nrPDB 188 2e-48 4PL5-B nrPDB 188 3e-48 6HV0-A nrPDB 186 7e-48 4NEU-A nrPDB 186 7e-48 4C59-A nrPDB 186 1e-47 6J5U-C nrPDB 186 1e-47 4X3F-A nrPDB 185 2e-47 4OW8-A nrPDB 185 2e-47 6B2Q-A nrPDB 185 2e-47 6CTH-A nrPDB 185 2e-47 4X7Q-B nrPDB 185 3e-47 3PLS-A nrPDB 184 5e-47 3ZZW-A nrPDB 183 1e-46 3AOX-A nrPDB 183 1e-46 3MDY-A nrPDB 181 2e-46 3Q4U-A nrPDB 180 5e-46 2PMN-X nrPDB 180 6e-46 4Y83-A nrPDB 179 2e-45 3G2F-A nrPDB 177 4e-45 5WNL-A nrPDB 177 6e-45 4FL3-A nrPDB 176 9e-45 5TE0-A nrPDB 176 1e-44 3SOC-A nrPDB 176 1e-44 3QD2-B nrPDB 175 2e-44 4IDT-A nrPDB 175 2e-44 3UIM-A nrPDB 175 3e-44 5LPZ-A nrPDB 175 3e-44 5WNO-A nrPDB 174 4e-44 1PY5-A nrPDB 174 5e-44 5LPV-A nrPDB 173 6e-44 5C26-A nrPDB 173 1e-43 4JLC-A nrPDB 172 2e-43 4EUU-A nrPDB 172 2e-43 4F0G-A nrPDB 172 2e-43 4EUT-A nrPDB 171 5e-43 4F9B-A nrPDB 170 5e-43 4G3E-A nrPDB 170 8e-43 3MY0-A nrPDB 170 8e-43 2QKW-B nrPDB 170 9e-43 3LMG-A nrPDB 168 2e-42 6O8B-A nrPDB 168 3e-42 5IKW-A nrPDB 168 3e-42 6NT9-A nrPDB 168 3e-42 4LQP-A nrPDB 168 4e-42 2BUJ-A nrPDB 168 4e-42 2Y4I-B nrPDB 165 2e-41 5XD6-A nrPDB 164 5e-41 2H34-A nrPDB 163 1e-40 2QLU-A nrPDB 163 1e-40 5AR8-A nrPDB 159 1e-39 5VDK-A nrPDB 158 3e-39 5E8V-A nrPDB 157 6e-39 6BFN-A nrPDB 156 9e-39 5VC6-A nrPDB 156 1e-38 4M66-A nrPDB 156 1e-38 6DC0-A nrPDB 150 6e-37 5CEK-A nrPDB 150 6e-37 4L00-A nrPDB 149 2e-36 3SV0-A nrPDB 148 2e-36 2CHL-A nrPDB 147 7e-36 5J0A-A nrPDB 146 1e-35 4BTK-A nrPDB 145 2e-35 4NFN-A nrPDB 144 4e-35 4TN6-A nrPDB 143 9e-35 2CMW-A nrPDB 143 1e-34 2C47-A nrPDB 142 2e-34 5FQD-C nrPDB 142 2e-34 3VHK-A nrPDB 141 3e-34 5X1R-A nrPDB 140 9e-34 5X18-A nrPDB 139 1e-33 4NT4-A nrPDB 138 3e-33 4M69-B nrPDB 138 3e-33 4BTF-A nrPDB 137 5e-33 3HNG-A nrPDB 136 1e-32 4RT7-A nrPDB 134 5e-32 1CSN-A nrPDB 129 1e-30 4JRN-A nrPDB 128 4e-30 2PZI-A nrPDB 128 4e-30 4Y12-A nrPDB 127 5e-30 4XHH-A nrPDB 126 9e-30 4XHL-A nrPDB 124 4e-29 5M07-A nrPDB 123 1e-28 5OAT-A nrPDB 116 2e-26 4IX6-A nrPDB 95 4e-20 Sequences not found previously or not previously below threshold: 4MWI-A nrPDB 131 4e-31 5L2Q-C nrPDB 126 1e-29 5USZ-A nrPDB 124 5e-29 3REP-A nrPDB 118 2e-27 5C01-A nrPDB 112 2e-25 4WOV-A nrPDB 111 3e-25 4L68-A nrPDB 109 2e-24 6EQI-C nrPDB 104 5e-23 5UV4-A nrPDB 102 1e-22 4I94-A nrPDB 100 1e-21 6J6I-B nrPDB 98 4e-21 5CLR-A nrPDB 89 3e-18 5UU1-A nrPDB 82 2e-16 2RSV-A nrPDB 81 8e-16 4O1O-A nrPDB 80 1e-15 2LAV-A nrPDB 79 2e-15 4OAU-C nrPDB 77 1e-14 4CI6-B nrPDB 77 1e-14 6EAS-A nrPDB 74 8e-14 5DMZ-A nrPDB 72 3e-13 6G4J-A nrPDB 70 1e-12 2JII-A nrPDB 64 8e-11 6M7Z-A nrPDB 59 2e-09 4CYJ-A nrPDB 59 3e-09 5GZA-A nrPDB 59 3e-09 6EWX-A nrPDB 58 7e-09 5GZ9-A nrPDB 56 1e-08 6G38-A nrPDB 56 3e-08 6BHC-A nrPDB 55 3e-08 4AZW-A nrPDB 54 9e-08 4AZV-A nrPDB 53 1e-07 4BWP-A nrPDB 52 4e-07 5VE6-A nrPDB 51 6e-07 3ENH-A nrPDB 51 6e-07 3Q60-A nrPDB 49 2e-06 6R5K-O nrPDB 48 5e-06 3BYV-A nrPDB 48 5e-06 4WWA-A nrPDB 48 6e-06 4CZY-B nrPDB 47 1e-05 3DZO-A nrPDB 47 1e-05 4XR7-L nrPDB 46 2e-05 2W1Z-A nrPDB 43 1e-04 1TQM-A nrPDB 39 0.003 6FAI-l nrPDB 34 0.062 2X8T-A nrPDB 34 0.071 6G18-v nrPDB 34 0.081 6DFL-A nrPDB 33 0.13 5YK0-A nrPDB 33 0.19 6FDN-A nrPDB 33 0.19 3LV4-A nrPDB 32 0.28 4FDJ-A nrPDB 32 0.35 >2BPM-A nrPDB Length = 309 Score = 452 bits (1163), Expect = e-127, Method: Composition-based stats. Identities = 298/298 (100%), Positives = 298/298 (100%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH Sbjct: 6 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 65 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS Sbjct: 66 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 125 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY Sbjct: 126 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 185 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF Sbjct: 186 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 245 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL Sbjct: 246 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 303 >6GU6-A nrPDB Length = 302 Score = 377 bits (969), Expect = e-105, Method: Composition-based stats. Identities = 194/297 (65%), Positives = 235/297 (79%), Gaps = 1/297 (0%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME++ K+EKIGEGTYGVVYK R+K TG+VVA+KKIRL++E EGVPSTAIREISLLKEL H Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 65 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASAL-TGIPLPLIKSYLFQLLQGLAFCH 119 PNIV L DV+ +++LYL+FEFL DLKK++D+ + L+KSYL+Q+LQG+ FCH Sbjct: 66 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 125 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 S RVLHRDLKPQNLLI+ +G IKLADFGLARAFG+P+R YTHEVVTLWYR+PE+LLG Sbjct: 126 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 185 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 YST VDIWS+G IFAE+ T++ LF GDSEIDQLFRIFR LGTP+ VWP V S+ DYK + Sbjct: 186 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 245 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296 FPKW + V LDE+G LLS+ML YDP KRIS K AL HP+F D+ + + Sbjct: 246 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 302 >3NIZ-A nrPDB Length = 311 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 182/294 (61%), Positives = 236/294 (80%), Gaps = 3/294 (1%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME +QK+EK+GEGTYGVVYKA++ G +VALK+IRLD E EG+PSTAIREISLLKEL+H Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLKELHH 78 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 PNIV L+DVIH+E L LVFEF+ +DLKK +D + TG+ IK YL+QLL+G+A CH Sbjct: 79 PNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENK-TGLQDSQIKIYLYQLLRGVAHCHQ 137 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 HR+LHRDLKPQNLLIN++GA+KLADFGLARAFG+PVR+YTHEVVTLWYRAP++L+G K Y Sbjct: 138 HRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKKY 197 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239 ST+VDIWS+GCIFAEM+T + LFPG ++ DQL +IF LGTP+ WP V +P +K + Sbjct: 198 STSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQRT 257 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293 F + ++ +S ++P ++G LLS ML +DPNKRISA+ A+ HP+F+D+ + Sbjct: 258 FQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLDPQI 311 >1V0B-A nrPDB Length = 288 Score = 357 bits (918), Expect = 2e-99, Method: Composition-based stats. Identities = 182/290 (62%), Positives = 215/290 (74%), Gaps = 2/290 (0%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME + +EKIGEGTYGVVYKA+N GE ALKKIRL+ E EG+PST IREIS+LKEL H Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NIVKL DVIHT+ +L LVFE L QDLKK +D G+ KS+L QLL G+A+CH Sbjct: 60 SNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEG-GLESVTAKSFLLQLLNGIAYCHD 118 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 RVLHRDLKPQNLLIN EG +K+ADFGLARAFG+PVR YTHEVVTLWYRAP++L+G K Y Sbjct: 119 RRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKY 178 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 ST +DIWS+GCIFAEMV LFPG SE DQL RIFR LGTP+ WP VT +P Y P+F Sbjct: 179 STTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNF 238 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 + + + LDE G LLS+ML DPN+RI+AK AL H +F++ Sbjct: 239 TVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKENN 288 >4AU8-A nrPDB Length = 296 Score = 353 bits (907), Expect = 4e-98, Method: Composition-based stats. Identities = 173/292 (59%), Positives = 215/292 (73%), Gaps = 2/292 (0%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++K+EKIGEGTYG V+KA+N+ T E+VALK++RLD + EGVPS+A+REI LLKEL H Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 65 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L DV+H++ KL LVFEF QDLKK+ D+ + ++KS+LFQLL+GL FCHS Sbjct: 66 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD-LDPEIVKSFLFQLLKGLGFCHSR 124 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 VLHRDLKPQNLLIN G +KLADFGLARAFG+PVR Y+ EVVTLWYR P++L G K YS Sbjct: 125 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 184 Query: 182 TAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 T++D+WS GCIFAE+ R LFPG+ DQL RIFR LGTP E WP +T +PDYKP Sbjct: 185 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 244 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 A VVP L+ GR LL +L +P +RISA+ AL HP+F D P Sbjct: 245 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >4KRC-A nrPDB Length = 317 Score = 351 bits (902), Expect = 2e-97, Method: Composition-based stats. Identities = 165/298 (55%), Positives = 217/298 (72%), Gaps = 10/298 (3%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 F+++EK+G GTY VYK NK TG VALK+++LD+E EG PSTAIREISL+KEL H N Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHEN 64 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDA----SALTGIPLPLIKSYLFQLLQGLAFC 118 IV+L DVIHTENKL LVFEF+ DLKK+MD+ + G+ L L+K + +QLLQGLAFC Sbjct: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 H +++LHRDLKPQNLLIN G +KL DFGLARAFG+PV T++ EVVTLWYRAP++L+G + Sbjct: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 YST++DIWS GCI AEM+T + LFPG ++ +QL IF +GTP+E +WP VT +P Y P Sbjct: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 Query: 239 SFPKWARQDFSKVV-----PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 + + +D +V+ PLD + L +L +P+ R+SAK AL HP+F + Sbjct: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYH 302 >1UA2-A nrPDB Length = 346 Score = 332 bits (851), Expect = 1e-91, Method: Composition-based stats. Identities = 133/300 (44%), Positives = 194/300 (64%), Gaps = 5/300 (1%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE---GVPSTAIREISLLKEL 58 + ++K++ +GEG + VYKAR+K T ++VA+KKI+L +E G+ TA+REI LL+EL Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 +HPNI+ LLD ++ + LVF+F+ DL+ + ++L + IK+Y+ LQGL + Sbjct: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV-LTPSHIKAYMLMTLQGLEYL 128 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 H H +LHRDLKP NLL++ G +KLADFGLA++FG P R YTH+VVT WYRAPE+L G + Sbjct: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y VD+W++GCI AE++ R PGDS++DQL RIF TLGTP E WP + S+PDY Sbjct: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV- 247 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298 +F + + +D L+ + ++P RI+A AL +F + P P +L Sbjct: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQL 307 >3GC0-A nrPDB Length = 329 Score = 325 bits (833), Expect = 2e-89, Method: Composition-based stats. Identities = 165/293 (56%), Positives = 223/293 (76%), Gaps = 8/293 (2%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ ++++ K+GEGTYG VYKA + +T E VA+K+IRL+ E EGVP TAIRE+SLLKEL H Sbjct: 33 IDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQH 92 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NI++L VIH ++L+L+FE+ DLKK+MD + + + +IKS+L+QL+ G+ FCHS Sbjct: 93 RNIIELKSVIHHNHRLHLIFEYAENDLKKYMDKNP--DVSMRVIKSFLYQLINGVNFCHS 150 Query: 121 HRVLHRDLKPQNLLIN-----TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 R LHRDLKPQNLL++ +K+ DFGLARAFG+P+R +THE++TLWYR PEILL Sbjct: 151 RRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILL 210 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 G ++YST+VDIWS+ CI+AEM+ + LFPGDSEIDQLF+IF LG PD+ WPGVT++PD Sbjct: 211 GSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALPD 270 Query: 236 YKPSFPKWARQDFSKVV-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 +K SFPK+ + +V+ LD++G LL+ ML DP KRISAK AL HP+F Sbjct: 271 WKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFS 323 >5G6V-A nrPDB Length = 324 Score = 322 bits (825), Expect = 1e-88, Method: Composition-based stats. Identities = 161/297 (54%), Positives = 211/297 (71%), Gaps = 3/297 (1%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME + K++K+GEGTY VYK ++KLT +VALK+IRL+ E EG P TAIRE+SLLK+L H Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 59 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NIV L D+IHTE L LVFE+L +DLK+++D I + +K +LFQLL+GLA+CH Sbjct: 60 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCG-NIINMHNVKLFLFQLLRGLAYCHR 118 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 +VLHRDLKPQNLLIN G +KLADFGLARA +P +TY +EVVTLWYR P+ILLG Y Sbjct: 119 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDY 178 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK-PS 239 ST +D+W +GCIF EM T R LFPG + +QL IFR LGTP E WPG+ S ++K + Sbjct: 179 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 238 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296 +PK+ + P LD DG LL+++L ++ RISA+ A+ HPFF + + + L Sbjct: 239 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKL 295 >1G3N-A nrPDB Length = 326 Score = 318 bits (816), Expect = 1e-87, Method: Composition-based stats. Identities = 145/299 (48%), Positives = 198/299 (66%), Gaps = 13/299 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARN-KLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59 + ++ V +IGEG YG V+KAR+ K G VALK++R+ T EG+P + IRE+++L+ L Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 60 --HPNIVKLLDVIH-----TENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112 HPN+V+L DV E KL LVFE + QDL ++D G+P IK +FQLL Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130 Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 +GL F HSHRV+HRDLKPQN+L+ + G IKLADFGLAR + + T VVTLWYRAPE Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPE 189 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 +LL Y+T VD+WS+GCIFAEM R+ LF G S++DQL +I +G P E WP + Sbjct: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 +P + +F + Q K V +DE G+ LL + L ++P KRISA +AL+HP+FQD+ + Sbjct: 249 LP--RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 >5EFQ-A nrPDB Length = 347 Score = 310 bits (795), Expect = 4e-85, Method: Composition-based stats. Identities = 133/313 (42%), Positives = 186/313 (59%), Gaps = 16/313 (5%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ F + IGEGTYG VYKAR+K TGE+VALKK+RLD E EG P TAIREI +L++L H Sbjct: 10 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 69 Query: 61 PNIVKLLDVIHTENK----------LYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ 110 +I+ + +++ + YLVFE++ DL ++ S L IKS++ Q Sbjct: 70 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLE-SGLVHFNENHIKSFMRQ 128 Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG-VPVRTYTHEVVTLWYR 169 L++GL +CH LHRD+K N+L+N G IKLADFGLAR + R YT++V+TLWYR Sbjct: 129 LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 188 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 PE+LLG + Y+ A+D+WS GCI E+ T++ +F + E+ QL I R G+P VWP Sbjct: 189 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPD 248 Query: 230 VTSMPDYKPSFPKWA-RQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 V +P + PK R+ + + L ML DP+KR +A+ AL F +D Sbjct: 249 VIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRD 308 Query: 289 VTK---PVPHLRL 298 V P P L L Sbjct: 309 VEPSKMPPPDLPL 321 >1CM8-A nrPDB Length = 367 Score = 307 bits (788), Expect = 3e-84, Method: Composition-based stats. Identities = 108/296 (36%), Positives = 162/296 (54%), Gaps = 14/296 (4%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 ++ ++ +G G YG V A + TG VA+KK+ ++E A RE+ LLK + H N+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 64 VKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 + LLDV + L YLV F+ DL K M + I+ ++Q+L+GL + Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK---HEKLGEDRIQFLVYQMLKGLRY 143 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 H+ ++HRDLKP NL +N + +K+ DFGLAR T VVT WYRAPE++L Sbjct: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS---EMTGYVVTRWYRAPEVILNW 200 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS--MPD 235 Y+ VDIWS+GCI AEM+T + LF G +DQL I + GTP + S + Sbjct: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 Y P+ ++DF+ ++ +LL +ML D +R++A ALAHP+F+ + Sbjct: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 >4NST-A nrPDB Length = 351 Score = 307 bits (787), Expect = 4e-84, Method: Composition-based stats. Identities = 128/301 (42%), Positives = 182/301 (60%), Gaps = 13/301 (4%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ F + IGEGTYG VYKA++K TGE+VALKK+RLD E EG P TAIREI +L++L H Sbjct: 12 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 71 Query: 61 PNIVKLLDVIHTENK----------LYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ 110 ++V + +++ + YLVFE++ DL ++ S L IKS++ Q Sbjct: 72 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLE-SGLVHFSEDHIKSFMKQ 130 Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVVTLWYR 169 L++GL +CH LHRD+K N+L+N G IKLADFGLAR + R YT++V+TLWYR Sbjct: 131 LMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYR 190 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 PE+LLG + Y+ A+D+WS GCI E+ T++ +F + E+ QL I R G+P VWP Sbjct: 191 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPD 250 Query: 230 VTSMPDYKPSFPKWA-RQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 V +P + PK R+ + + LL ML DP+KR +A+ L F +D Sbjct: 251 VIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKD 310 Query: 289 V 289 V Sbjct: 311 V 311 >4EWQ-A nrPDB Length = 383 Score = 307 bits (786), Expect = 5e-84, Method: Composition-based stats. Identities = 112/299 (37%), Positives = 160/299 (53%), Gaps = 14/299 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E +Q + +G G YG V A + TG VA+KK+ ++ RE+ LLK + H Sbjct: 45 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 104 Query: 62 NIVKLLDVI------HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 N++ LLDV N +YLV + DL + LT ++ ++Q+L+GL Sbjct: 105 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD---DHVQFLIYQILRGL 161 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 + HS ++HRDLKP NL +N + +K+ DFGLAR T V T WYRAPEI+L Sbjct: 162 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTGYVATRWYRAPEIML 218 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT--SM 233 +Y+ VDIWS+GCI AE++T R LFPG IDQL I R +GTP + ++ S Sbjct: 219 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 278 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 +Y S + + +F+ V + LL +ML D +KRI+A ALAH +F P Sbjct: 279 RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 337 >4BBM-A nrPDB Length = 331 Score = 305 bits (783), Expect = 1e-83, Method: Composition-based stats. Identities = 118/289 (40%), Positives = 167/289 (57%), Gaps = 3/289 (1%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME ++ + +GEG+YG+V K RNK TG +VA+KK + + V A+REI LLK+L H Sbjct: 24 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 83 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 N+V LL+V + + YLVFEF+ + ++ G+ +++ YLFQ++ G+ FCHS Sbjct: 84 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLEL-FPNGLDYQVVQKYLFQIINGIGFCHS 142 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 H ++HRD+KP+N+L++ G +KL DFG AR P Y EV T WYRAPE+L+G Y Sbjct: 143 HNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKY 202 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY-KPS 239 AVD+W++GC+ EM LFPGDS+IDQL+ I LG P + Sbjct: 203 GKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVR 262 Query: 240 FPKW-ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 P+ R+ + P L E L + LH DP+KR L H FFQ Sbjct: 263 LPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >3OHT-A nrPDB Length = 389 Score = 305 bits (782), Expect = 2e-83, Method: Composition-based stats. Identities = 111/299 (37%), Positives = 162/299 (54%), Gaps = 14/299 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E +Q + +G G YG V + + +G +A+KK+ ++ RE+ LLK + H Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 110 Query: 62 NIVKLLDVI------HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 N++ LLDV N +YLV + DL + LT ++ ++Q+L+GL Sbjct: 111 NVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTD---DHVQFLIYQILRGL 167 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 + HS ++HRDLKP NL +N + +K+ DFGLAR T V T WYRAPEI+L Sbjct: 168 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTGYVATRWYRAPEIML 224 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM-- 233 +Y+ VDIWS+GCI AE++T R LFPG I+QL +I R GTP V + S Sbjct: 225 NWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHEA 284 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 +Y S P+ +++F+ V + LL +ML D +KRI+A ALAHP+F P Sbjct: 285 RNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQYHDP 343 >4MYG-A nrPDB Length = 372 Score = 305 bits (781), Expect = 2e-83, Method: Composition-based stats. Identities = 115/291 (39%), Positives = 162/291 (55%), Gaps = 15/291 (5%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 +G G YG V A +K +GE VA+KK+ ++E A RE+ LLK + H N++ LLDV Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 70 IHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 + L YLV F+ DL+K M I+ ++Q+L+GL + HS V Sbjct: 111 FTPASSLRNFYDFYLVMPFMQTDLQKIM----GMEFSEEKIQYLVYQMLKGLKYIHSAGV 166 Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 +HRDLKP NL +N + +K+ DFGLAR T VVT WYRAPE++L +Y+ Sbjct: 167 VHRDLKPGNLAVNEDCELKILDFGLARHADA---EMTGYVVTRWYRAPEVILSWMHYNQT 223 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP--DEVVWPGVTSMPDYKPSFP 241 VDIWS+GCI AEM+T + LF G +DQL +I + G P + V + Y S P Sbjct: 224 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLP 283 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 + R+DF+++ P LL +ML D +KR++A AL HPFF+ P Sbjct: 284 QTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 334 >2F9G-A nrPDB Length = 353 Score = 305 bits (781), Expect = 2e-83, Method: Composition-based stats. Identities = 113/308 (36%), Positives = 157/308 (50%), Gaps = 22/308 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 +FQ +GEG YGVV A +K TGE+VA+KKI + +REI +LK H N Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHEN 70 Query: 63 IVKLL-----DVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 I+ + D N++Y++ E + DL + + + I+ +++Q L+ + Sbjct: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM---LSDDHIQYFIYQTLRAVKV 127 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT----------YTHEVVTLW 167 H V+HRDLKP NLLIN+ +K+ DFGLAR T V T W Sbjct: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227 YRAPE++L YS A+D+WS GCI AE+ RR +FPG QL IF +GTP Sbjct: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Query: 228 PGVTSMP---DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284 P +Y S P + K+ P ++ G LL +ML +DP KRI+AK AL HP Sbjct: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 Query: 285 FFQDVTKP 292 + Q P Sbjct: 308 YLQTYHDP 315 >4AGU-A nrPDB Length = 311 Score = 304 bits (780), Expect = 3e-83, Method: Composition-based stats. Identities = 114/293 (38%), Positives = 170/293 (58%), Gaps = 3/293 (1%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME ++K+ KIGEG+YGVV+K RN+ TG++VA+KK + + A+REI +LK+L H Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 PN+V LL+V + +L+LVFE+ + +D G+P L+KS +Q LQ + FCH Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQ-RGVPEHLVKSITWQTLQAVNFCHK 120 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 H +HRD+KP+N+LI IKL DFG AR P Y EV T WYR+PE+L+G Y Sbjct: 121 HNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQY 180 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGT--PDEVVWPGVTSMPDYKP 238 VD+W++GC+FAE+++ L+PG S++DQL+ I +TLG P Sbjct: 181 GPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK 240 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 + P + LL LH DP +R++ + L HP+F+++ + Sbjct: 241 IPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIRE 293 >4QTB-A nrPDB Length = 380 Score = 304 bits (778), Expect = 4e-83, Method: Composition-based stats. Identities = 111/301 (36%), Positives = 166/301 (55%), Gaps = 14/301 (4%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + +++ IGEG YG+V A + + VA+KKI E + +REI +L H N Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHEN 100 Query: 63 IVKLLDVIHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 ++ + D++ +Y+V + + DL K + + + I +L+Q+L+GL + Sbjct: 101 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ---LSNDHICYFLYQILRGLKY 157 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT---YTHEVVTLWYRAPEIL 174 HS VLHRDLKP NLLINT +K+ DFGLAR T V T WYRAPEI+ Sbjct: 158 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 217 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 L K Y+ ++DIWS+GCI AEM++ R +FPG +DQL I LG+P + + +M Sbjct: 218 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 277 Query: 235 --DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 +Y S P + ++K+ P D LL +ML ++PNKRI+ + ALAHP+ + P Sbjct: 278 ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDP 337 Query: 293 V 293 Sbjct: 338 T 338 >4IC8-A nrPDB Length = 442 Score = 304 bits (778), Expect = 4e-83, Method: Composition-based stats. Identities = 116/303 (38%), Positives = 166/303 (54%), Gaps = 14/303 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ +E IG G YGVV AR +LTG+ VA+KKI + +RE+ +LK H Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 114 Query: 62 NIVKLLDV------IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 NI+ + D+ +Y+V + + DL + + +S + L ++ +L+QLL+GL Sbjct: 115 NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSS--QPLTLEHVRYFLYQLLRGL 172 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----THEVVTLWYRAP 171 + HS +V+HRDLKP NLL+N +K+ DFG+AR + T V T WYRAP Sbjct: 173 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 232 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP--G 229 E++L Y+ A+D+WS+GCIF EM+ RR LFPG + + QL I LGTP V G Sbjct: 233 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 292 Query: 230 VTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 + Y S P + V P D SLL +ML ++P+ RISA AAL HPF Sbjct: 293 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY 352 Query: 290 TKP 292 P Sbjct: 353 HDP 355 >2W96-B nrPDB Length = 306 Score = 302 bits (773), Expect = 1e-82, Method: Composition-based stats. Identities = 133/294 (45%), Positives = 188/294 (63%), Gaps = 12/294 (4%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN--- 59 ++ V +IG G YG VYKAR+ +G VALK +R+ EG+P + +RE++LL+ L Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFE 64 Query: 60 HPNIVKLLDVIHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 HPN+V+L+DV T K+ LVFE + QDL+ ++D + G+P IK + Q L+G Sbjct: 65 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 124 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 L F H++ ++HRDLKP+N+L+ + G +KLADFGLAR + + VVTLWYRAPE+L Sbjct: 125 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALDPVVVTLWYRAPEVL 183 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 L Y+T VD+WS+GCIFAEM R+ LF G+SE DQL +IF +G P E WP S+P Sbjct: 184 LQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 242 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + +FP + VVP ++E G LL +ML ++P+KRISA AL H + Sbjct: 243 --RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 294 >5NGU-A nrPDB Length = 381 Score = 299 bits (767), Expect = 8e-82, Method: Composition-based stats. Identities = 110/300 (36%), Positives = 162/300 (54%), Gaps = 14/300 (4%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + + IGEG YG+V A + L VA+KKI E + +REI +L H N Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHEN 101 Query: 63 IVKLLDVI-----HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 I+ + D+I +Y+V + + DL K + + I +L+Q+L+GL + Sbjct: 102 IIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQ---HLSNDHICYFLYQILRGLKY 158 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT---YTHEVVTLWYRAPEIL 174 HS VLHRDLKP NLL+NT +K+ DFGLAR T V T WYRAPEI+ Sbjct: 159 IHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIM 218 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 L K Y+ ++DIWS+GCI AEM++ R +FPG +DQL I LG+P + + ++ Sbjct: 219 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 278 Query: 235 --DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 +Y S P + ++++ P D LL +ML ++P+KRI + ALAHP+ + P Sbjct: 279 ARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDP 338 >6DTL-A nrPDB Length = 364 Score = 299 bits (767), Expect = 8e-82, Method: Composition-based stats. Identities = 107/291 (36%), Positives = 159/291 (54%), Gaps = 9/291 (3%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 + IG+G YG+V A N T E VA+KKI + + +REI LL+ ++H NIV + Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 94 Query: 67 LDVIHTE-----NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 D+I N +Y+ +E + DL + + ++ + + +L+Q+L+GL + HS Sbjct: 95 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN--QALSEEHCQYFLYQILRGLKYIHSA 152 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 VLHRDLKP NLL+N +K+ DFGLAR T VVT WYRAPE+LL Y+ Sbjct: 153 NVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSDYT 211 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD-YKPSF 240 A+D+WS+GCIF E++ R+ LFPG + QL + +GTP E + Y Sbjct: 212 AAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 271 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 P + RQ + P + L+ +ML +DP +RI+ ALAHP+ + Sbjct: 272 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 322 >4ZSG-A nrPDB Length = 347 Score = 299 bits (765), Expect = 1e-81, Method: Composition-based stats. Identities = 116/303 (38%), Positives = 166/303 (54%), Gaps = 14/303 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ +E IG G YGVV AR +LTG+ VA+KKI + +RE+ +LK H Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 66 Query: 62 NIVKLLDV------IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 NI+ + D+ +Y+V + + DL + + +S + L ++ +L+QLL+GL Sbjct: 67 NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSS--QPLTLEHVRYFLYQLLRGL 124 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----THEVVTLWYRAP 171 + HS +V+HRDLKP NLL+N +K+ DFG+AR + T V T WYRAP Sbjct: 125 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 184 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP--G 229 E++L Y+ A+D+WS+GCIF EM+ RR LFPG + + QL I LGTP V G Sbjct: 185 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 244 Query: 230 VTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 + Y S P + V P D SLL +ML ++P+ RISA AAL HPF Sbjct: 245 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY 304 Query: 290 TKP 292 P Sbjct: 305 HDP 307 >5Z33-A nrPDB Length = 425 Score = 298 bits (763), Expect = 2e-81, Method: Composition-based stats. Identities = 112/301 (37%), Positives = 162/301 (53%), Gaps = 13/301 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-H 60 E + +++G+G YG+V A N T E VA+KK+ + + A+REI LL+ H Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGH 90 Query: 61 PNIVKLLDVIHTE----NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 NI L D+ N+ YL E + DL + + + +S+++Q+L GL Sbjct: 91 RNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRS--GQPLTDAHFQSFIYQILCGLK 148 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT----YTHEVVTLWYRAPE 172 + HS VLHRDLKP NLL+N + +K+ DFGLAR F V T V T WYRAPE Sbjct: 149 YIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPE 208 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP--GV 230 I+L + Y+ A+D+WS+GCI AE++ R F G +DQL +I LGTP+E G Sbjct: 209 IMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGS 268 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 +Y + P A++ F + P + D LL +ML +DP+ RIS + AL HP+ Sbjct: 269 PRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYLHIWH 328 Query: 291 K 291 Sbjct: 329 D 329 >3GC9-A nrPDB Length = 370 Score = 298 bits (763), Expect = 2e-81, Method: Composition-based stats. Identities = 107/299 (35%), Positives = 159/299 (53%), Gaps = 14/299 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + Q + +G G YG V A + + VA+KK+ ++ RE+ LLK L H Sbjct: 28 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 87 Query: 62 NIVKLLDVI------HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 N++ LLDV +++YLV + DL + + A + ++ ++QLL+GL Sbjct: 88 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQA---LSDEHVQFLVYQLLRGL 144 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 + HS ++HRDLKP N+ +N + +++ DFGLAR T V T WYRAPEI+L Sbjct: 145 KYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQ---ADEEMTGYVATRWYRAPEIML 201 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS--M 233 +Y+ VDIWS+GCI AE++ +ALFPG IDQL RI +GTP V ++S Sbjct: 202 NWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHA 261 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 Y S P ++D S + + LL +ML D ++R+SA ALAH +F P Sbjct: 262 RTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 320 >3MIA-A nrPDB Length = 351 Score = 294 bits (752), Expect = 5e-80, Method: Composition-based stats. Identities = 122/310 (39%), Positives = 180/310 (58%), Gaps = 18/310 (5%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 + ++K+ KIG+GT+G V+KAR++ TG+ VALKK+ ++ E EG P TA+REI +L+ L H Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 Query: 61 PNIVKLLDVIHT--------ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112 N+V L+++ T + +YLVF+F DL + ++ L L IK + LL Sbjct: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL-SNVLVKFTLSEIKRVMQMLL 134 Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT----YTHEVVTLWY 168 GL + H +++LHRD+K N+LI +G +KLADFGLARAF + + YT+ VVTLWY Sbjct: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228 R PE+LLG + Y +D+W GCI AEM TR + G++E QL I + G+ VWP Sbjct: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 Query: 229 GVTSMPDY-KPSFPKWARQDFSKVVPPL--DEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 V + Y K K ++ + D L+ ++L DP +RI + AL H F Sbjct: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 Query: 286 FQDVTKPVPH 295 F + P+P Sbjct: 315 FW--SDPMPS 322 >3NCG-A nrPDB Length = 486 Score = 293 bits (750), Expect = 6e-80, Method: Composition-based stats. Identities = 83/298 (27%), Positives = 142/298 (47%), Gaps = 32/298 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E + V +G+G++G V K ++++T + A+K I + ST +RE+ LLK+L+HP Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NI+KL +++ + Y+V E + F + + Q+ G+ + H H Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGG-ELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 122 RVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 ++HRDLKP+N+L+ + + IK+ DFGL+ F + + T +Y APE+L G Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTK-MKDRIGTAYYIAPEVLRGT- 198 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y D+WS G I +++ F G +E D L R+ Y Sbjct: 199 -YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV----------------ETGKYAF 241 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296 P+W + +D + L+ +ML + P+ RI+A L HP+ Q + P + Sbjct: 242 DLPQWR---------TISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTI 290 >4MVF-A nrPDB Length = 506 Score = 293 bits (750), Expect = 8e-80, Method: Composition-based stats. Identities = 85/301 (28%), Positives = 147/301 (48%), Gaps = 36/301 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + + EK+G+GTYG VYK +K+T ++ A+K+ + D +EI ++K+L+HP Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINR--FFQEIEIMKKLDHP 114 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHS 120 NIVKL + +N +YL+ E ++ D+ G + + Q+ + + HS Sbjct: 115 NIVKLYETYENDNYIYLIMELCSG--RELFDSIIENGSFTEKNAATIMKQIFSAIFYLHS 172 Query: 121 HRVLHRDLKPQNLLI---NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 ++HRDLKP+N L N + +K+ DFGL++ G T + T +Y AP++L G Sbjct: 173 LNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLG-TGEFTTTKAGTPYYVAPQVLDG- 230 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 Y DIWS G I ++ F GD++ + L ++ + E W Sbjct: 231 -KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWG--------- 280 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR 297 + D ++L++++L Y+PN+R + + AL HP+ +TK H+ Sbjct: 281 ----------------SISSDAKNLITKLLTYNPNERCTIEEALNHPWITQMTKSHEHVE 324 Query: 298 L 298 L Sbjct: 325 L 325 >3OZ6-A nrPDB Length = 388 Score = 291 bits (745), Expect = 3e-79, Method: Composition-based stats. Identities = 116/335 (34%), Positives = 176/335 (52%), Gaps = 47/335 (14%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59 + ++ V+K+G+G YG+V+K+ ++ TGEVVA+KKI + REI +L EL+ Sbjct: 8 LRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSG 67 Query: 60 HPNIVKLLDVIHTENK--LYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 H NIV LL+V+ +N +YLVF+++ DL + A+ L + + ++QL++ + + Sbjct: 68 HENIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRANILEPVHKQYV---VYQLIKVIKY 124 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF---------------------GVPV 156 HS +LHRD+KP N+L+N E +K+ADFGL+R+F Sbjct: 125 LHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQ 184 Query: 157 RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF 216 T V T WYRAPEILLG Y+ +D+WSLGCI E++ + +FPG S ++QL RI Sbjct: 185 PILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERII 244 Query: 217 RTLGTPDEVVWPGVTS-----------------MPDYKPSFPKWARQDFSKVVPPLD--E 257 + P + S + + F KW + K+ P D E Sbjct: 245 GVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKW-KNLLLKINPKADCNE 303 Query: 258 DGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 + LL ++L ++PNKRISA AL HPF P Sbjct: 304 EALDLLDKLLQFNPNKRISANDALKHPFVSIFHNP 338 >5JN2-A nrPDB Length = 525 Score = 290 bits (744), Expect = 3e-79, Method: Composition-based stats. Identities = 83/296 (28%), Positives = 147/296 (49%), Gaps = 35/296 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNH 60 + ++ +G+G++G V ++K+TG+ A+K I + + + + +RE+ LLK+L+H Sbjct: 67 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 126 Query: 61 PNIVKLLDVIHTENKLYLVFE-FLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 PNI+KL + + YLV E + +L + + + Q+L G+ + H Sbjct: 127 PNIMKLYEFFEDKGYFYLVGEVYTGGELFD--EIISRKRFSEVDAARIIRQVLSGITYMH 184 Query: 120 SHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 ++++HRDLKP+NLL+ + + I++ DFGL+ F + ++ T +Y APE+L G Sbjct: 185 KNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEA-SKKMKDKIGTAYYIAPEVLHG 243 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 Y D+WS G I +++ F G +E D L ++ + Y Sbjct: 244 T--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKG----------------KY 285 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 P+W + + E + L+ +ML Y P+ RISA+ AL H + Q TK Sbjct: 286 TFELPQWKK---------VSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKE 332 >4BGQ-A nrPDB Length = 304 Score = 287 bits (736), Expect = 3e-78, Method: Composition-based stats. Identities = 110/291 (37%), Positives = 164/291 (56%), Gaps = 6/291 (2%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 M F+ + +GEG YGVV K R+K T E+VA+KK + E E V T +RE+ +L+ L Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NIV+L + KLYLVFE++ +++ + ++ G+P +KSY++QL++ + +CH Sbjct: 71 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLE-EMPNGVPPEKVKSYIYQLIKAIHWCHK 129 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR-TYTHEVVTLWYRAPEILLGCKY 179 + ++HRD+KP+NLLI+ +KL DFG AR Y EV T WYR+PE+LLG Sbjct: 130 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGA-P 188 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY--- 236 Y +VD+WS+GCI E+ + LFPG+SEIDQLF I + LG S P + Sbjct: 189 YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 248 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 + + + + L+ L+ +L DP R + L HP FQ Sbjct: 249 RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >3DFA-A nrPDB Length = 286 Score = 287 bits (735), Expect = 4e-78, Method: Composition-based stats. Identities = 82/292 (28%), Positives = 140/292 (47%), Gaps = 32/292 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E + V +G+G++G V K ++++T + A+K I + ST +RE+ LLK+L+HP Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NI+KL +++ + Y+V E + F + + Q+ G+ + H H Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGG-ELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 122 RVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 ++HRDLKP+N+L+ + + IK+ DFGL+ F + + T +Y APE+L G Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTK-MKDRIGTAYYIAPEVLRGT- 198 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y D+WS G I +++ F G +E D L R+ Y Sbjct: 199 -YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV----------------ETGKYAF 241 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 P+W + +D + L+ +ML + P+ RI+A L HP+ Q + Sbjct: 242 DLPQWR---------TISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYS 284 >1JNK-A nrPDB Length = 423 Score = 286 bits (732), Expect = 9e-78, Method: Composition-based stats. Identities = 111/313 (35%), Positives = 164/313 (52%), Gaps = 25/313 (7%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ +Q ++ IG G G+V A + + VA+KK+ + + A RE+ L+K +NH Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 61 PNIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 NI+ LL+V + L YLV E + +L + + + + L+Q+L G Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM----ELDHERMSYLLYQMLCG 176 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 + HS ++HRDLKP N+++ ++ +K+ DFGLAR G T VVT +YRAPE++ Sbjct: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVI 235 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP-DEVVWPGVTSM 233 LG Y VDIWS+GCI EMV + LFPG IDQ ++ LGTP E + ++ Sbjct: 236 LGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 Query: 234 PDYKPSFPKWARQDFSKVVP----PLDED--------GRSLLSQMLHYDPNKRISAKAAL 281 +Y + PK+A F K+ P P D + R LLS+ML DP KRIS AL Sbjct: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 Query: 282 AHPFFQDVTKPVP 294 HP+ P Sbjct: 355 QHPYINVWYDPAE 367 >4QNY-A nrPDB Length = 354 Score = 285 bits (730), Expect = 1e-77, Method: Composition-based stats. Identities = 93/299 (31%), Positives = 154/299 (51%), Gaps = 11/299 (3%) Query: 2 ENFQKVEKIGEGTYGVVYKARN-KLTGEVVALKKIRLDTETEGV-PSTAIREISLLKELN 59 + + IG G+YGVV +AR+ K +VA+K++ + E + +REI LL N Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFN 79 Query: 60 HPNIVKLLDVIHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 NI+ L +++ E+ Y+V + + DLK+ + + + I+ +++Q L+ Sbjct: 80 DDNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRS--GQELTEAHIQFFIYQALRA 137 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 L HS V+HRD+ P N+L+NT +K+ DFGLA+ T V WYRAPE++ Sbjct: 138 LHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELV 197 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP--GVTS 232 + K YS +D+W +GCI E++ R LF G ++QL +I +GTP E G ++ Sbjct: 198 MEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSA 257 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 Y + D+ + P + LL ML ++P +RI+ A+ HPF + + Sbjct: 258 AQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHD 316 >3LIJ-A nrPDB Length = 494 Score = 284 bits (728), Expect = 2e-77, Method: Composition-based stats. Identities = 89/301 (29%), Positives = 148/301 (49%), Gaps = 33/301 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E +Q+V+K+G G YG V R+K+T A+K IR + + S + E+++LK L+HP Sbjct: 37 EMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHP 96 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NI+KL D + YLV E ++ + F + + Q+L G+ + H H Sbjct: 97 NIMKLYDFFEDKRNYYLVME-CYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKH 155 Query: 122 RVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 ++HRDLKP+NLL+ + + IK+ DFGL+ F + + T +Y APE+L K Sbjct: 156 NIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFEN-QKKMKERLGTAYYIAPEVLR--K 212 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y D+WS+G I ++ F G ++ + L ++ + Y Sbjct: 213 KYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKG----------------KYTF 256 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV-TKPVPHLR 297 P+W + E + L+ QML +D +RISA+ AL HP+ +++ +K + Sbjct: 257 DSPEWKN---------VSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEMCSKKESGIE 307 Query: 298 L 298 L Sbjct: 308 L 308 >3MA6-A nrPDB Length = 298 Score = 284 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 83/296 (28%), Positives = 147/296 (49%), Gaps = 35/296 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNH 60 + ++ +G+G++G V ++K+TG+ A+K I + + + + +RE+ LLK+L+H Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 91 Query: 61 PNIVKLLDVIHTENKLYLVFE-FLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 PNI+KL + + YLV E + +L + + + Q+L G+ + H Sbjct: 92 PNIMKLYEFFEDKGYFYLVGEVYTGGELFD--EIISRKRFSEVDAARIIRQVLSGITYMH 149 Query: 120 SHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 ++++HRDLKP+NLL+ + + I++ DFGL+ F + ++ T +Y APE+L G Sbjct: 150 KNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEA-SKKMKDKIGTAYYIAPEVLHG 208 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 Y D+WS G I +++ F G +E D L ++ + Y Sbjct: 209 T--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKG----------------KY 250 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 P+W + + E + L+ +ML Y P+ RISA+ AL H + Q TK Sbjct: 251 TFELPQWKK---------VSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKE 297 >2XS0-A nrPDB Length = 386 Score = 284 bits (727), Expect = 4e-77, Method: Composition-based stats. Identities = 105/311 (33%), Positives = 159/311 (51%), Gaps = 25/311 (8%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ +Q ++ IG G G+V A + + VA+KK+ + + A RE+ L+K +NH Sbjct: 25 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 84 Query: 61 PNIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 NI+ LL+V + L Y+V E + +L + + + + L+Q+L G Sbjct: 85 KNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQM----ELDHERMSYLLYQMLCG 140 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 + HS ++HRDLKP N+++ ++ +K+ DFGLAR G VVT +YRAPE++ Sbjct: 141 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMVPFVVTRYYRAPEVI 199 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP-DEVVWPGVTSM 233 LG Y VDIWS+GCI EM+ LFPG IDQ ++ LGTP E + ++ Sbjct: 200 LGMG-YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTV 258 Query: 234 PDYKPSFPKWARQDFSKVVPPL------------DEDGRSLLSQMLHYDPNKRISAKAAL 281 Y + PK+A F K+ P + R LLS+ML D +KRIS AL Sbjct: 259 RTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEAL 318 Query: 282 AHPFFQDVTKP 292 HP+ P Sbjct: 319 QHPYINVWYDP 329 >5AWM-A nrPDB Length = 394 Score = 283 bits (724), Expect = 7e-77, Method: Composition-based stats. Identities = 105/319 (32%), Positives = 158/319 (49%), Gaps = 32/319 (10%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + + IG G G+V A + +T + VA+KK+ + A RE L+K +NH N Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 104 Query: 63 IVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 I+ LL+ + L YLV E + +L + + + + L+Q+L G+ Sbjct: 105 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM----DLDHDRMSYLLYQMLCGIK 160 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 HS ++HRDLKP N+++ + +K+ DFGLAR G T VVT +YRAPE++LG Sbjct: 161 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVILG 219 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP-DEVVWPGVTSMPD 235 Y+ VDIWS+GCI EM+ LFPG IDQ +I LGTP + ++ + Sbjct: 220 MG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 278 Query: 236 YKPSFPKWARQDFSKVVPP-------------LDEDGRSLLSQMLHYDPNKRISAKAALA 282 Y + P++ F ++ P D R+LLS+ML DP +RIS AL Sbjct: 279 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 338 Query: 283 HPFF------QDVTKPVPH 295 H + ++V P P Sbjct: 339 HEYINVWYDAEEVDAPAPE 357 >3HZT-A nrPDB Length = 467 Score = 282 bits (723), Expect = 9e-77, Method: Composition-based stats. Identities = 87/289 (30%), Positives = 142/289 (49%), Gaps = 33/289 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS-TAIREISLLKELNH 60 + +Q+V+K+G G YG V ++KLTG A+K I+ + T S + E+++LK+L+H Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 PNI+KL + + YLV E + F + + Q+L G + H Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGG-ELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHK 122 Query: 121 HRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 H ++HRDLKP+NLL+ + + IK+ DFGL+ F V + + T +Y APE+L Sbjct: 123 HNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGK-MKERLGTAYYIAPEVLR-- 179 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 K Y D+WS G I ++ F G ++ + L R+ + + Sbjct: 180 KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKG----------------KFS 223 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P W + + ++ + L+ ML Y+P+KRISA+ AL HP+ Sbjct: 224 FDPPDWTQ---------VSDEAKQLVKLMLTYEPSKRISAEEALNHPWI 263 >3FI2-A nrPDB Length = 353 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 110/306 (35%), Positives = 163/306 (53%), Gaps = 25/306 (8%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ +Q ++ IG G G+V A + + VA+KK+ + + A RE+ L+K +NH Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 82 Query: 61 PNIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 NI+ LL+V + L YLV E + +L + + + + L+Q+L G Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM----ELDHERMSYLLYQMLCG 138 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 + HS ++HRDLKP N+++ ++ +K+ DFGLAR G T VVT +YRAPE++ Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVI 197 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP-DEVVWPGVTSM 233 LG Y VDIWS+GCI EMV + LFPG IDQ ++ LGTP E + ++ Sbjct: 198 LGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 256 Query: 234 PDYKPSFPKWARQDFSKVVP----PLDED--------GRSLLSQMLHYDPNKRISAKAAL 281 +Y + PK+A F K+ P P D + R LLS+ML DP KRIS AL Sbjct: 257 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 316 Query: 282 AHPFFQ 287 HP+ Sbjct: 317 QHPYIN 322 >3E7O-A nrPDB Length = 360 Score = 281 bits (720), Expect = 2e-76, Method: Composition-based stats. Identities = 104/313 (33%), Positives = 159/313 (50%), Gaps = 25/313 (7%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ +Q+++ IG G G+V A + + G VA+KK+ + + A RE+ LLK +NH Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 80 Query: 61 PNIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 NI+ LL+V + L YLV E + +L + + + + L+Q+L G Sbjct: 81 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHM----ELDHERMSYLLYQMLCG 136 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 + HS ++HRDLKP N+++ ++ +K+ DFGLAR T VVT +YRAPE++ Sbjct: 137 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNF-MMTPYVVTRYYRAPEVI 195 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD-EVVWPGVTSM 233 LG Y VDIWS+GCI E+V +F G IDQ ++ LGTP E + ++ Sbjct: 196 LGMG-YKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTV 254 Query: 234 PDYKPSFPKWARQDFSKVVPP------------LDEDGRSLLSQMLHYDPNKRISAKAAL 281 +Y + P + F ++ P R LLS+ML DP+KRIS AL Sbjct: 255 RNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEAL 314 Query: 282 AHPFFQDVTKPVP 294 HP+ P Sbjct: 315 RHPYITVWYDPAE 327 >3ZDU-A nrPDB Length = 325 Score = 280 bits (718), Expect = 4e-76, Method: Composition-based stats. Identities = 99/288 (34%), Positives = 155/288 (53%), Gaps = 4/288 (1%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME ++ + K+GEG+YG V K ++K TG++VA+K + + V A+REI LK+ +H Sbjct: 2 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIF-YERPEQSVNKIAMREIKFLKQFHH 60 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 N+V L++V + K++LVFEF+ + + G+ ++ YLFQ+L+ + + HS Sbjct: 61 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDEL-QHYCHGLESKRLRKYLFQILRAIDYLHS 119 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 + ++HRD+KP+N+L++ G KL DFG AR P Y EV T WYRAPE++L Y Sbjct: 120 NNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSY 179 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VDIW+LGC+ EM T P S++D L +I +G + + P + Sbjct: 180 GKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVV 239 Query: 241 PKWARQDF--SKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 + K P L+ ++ L DP RIS+ L H +F Sbjct: 240 LPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 287 >3DXN-A nrPDB Length = 287 Score = 280 bits (718), Expect = 4e-76, Method: Composition-based stats. Identities = 87/289 (30%), Positives = 142/289 (49%), Gaps = 33/289 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS-TAIREISLLKELNH 60 + +Q+V+K+G G YG V ++KLTG A+K I+ + T S + E+++LK+L+H Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 PNI+KL + + YLV E + F + + Q+L G + H Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGG-ELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHK 139 Query: 121 HRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 H ++HRDLKP+NLL+ + + IK+ DFGL+ F V + + T +Y APE+L Sbjct: 140 HNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGK-MKERLGTAYYIAPEVLR-- 196 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 K Y D+WS G I ++ F G ++ + L R+ + + Sbjct: 197 KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKG----------------KFS 240 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P W + + ++ + L+ ML Y+P+KRISA+ AL HP+ Sbjct: 241 FDPPDWTQ---------VSDEAKQLVKLMLTYEPSKRISAEEALNHPWI 280 >5AIR-A nrPDB Length = 430 Score = 280 bits (718), Expect = 4e-76, Method: Composition-based stats. Identities = 98/300 (32%), Positives = 171/300 (57%), Gaps = 20/300 (6%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 + + IG G++GVVY+A+ +GE+VA+KK+ D + RE+ ++++L+H NI Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 119 Query: 64 VKLLDVIHTENK------LYLVFEFLHQDLKKFMD--ASALTGIPLPLIKSYLFQLLQGL 115 V+L ++ + L LV +++ + + + + A +P+ +K Y++QL + L Sbjct: 120 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 179 Query: 116 AFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 A+ HS + HRD+KPQNLL++ + +KL DFG A+ V + + +YRAPE++ Sbjct: 180 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRAPELI 238 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 G Y++++D+WS GC+ AE++ + +FPGDS +DQL I + LGTP + P Sbjct: 239 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN--P 296 Query: 235 DY-KPSFPKWARQDFSKVV-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 +Y + FP+ ++KV P + +L S++L Y P R++ A AH FF ++ P Sbjct: 297 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 356 >5FG8-A nrPDB Length = 285 Score = 277 bits (709), Expect = 4e-75, Method: Composition-based stats. Identities = 86/288 (29%), Positives = 136/288 (47%), Gaps = 30/288 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +N+ E++G+G + +V + K TG A K I T RE + ++L+HP Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHP 73 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L D I EN YLVF+ + + F D A + Q+L+ + CH + Sbjct: 74 NIVRLHDSIQEENYHYLVFDLVTGG-ELFEDIVAREFYSEADASHCIQQILESVNHCHQN 132 Query: 122 RVLHRDLKPQNLLINTEGA---IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 V+HRDLKP+NLL+ ++ +KLADFGLA + + T Y +PE+L + Sbjct: 133 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKK-E 191 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y +VDIW+ G I ++ F D + +L+ + Y Sbjct: 192 PYGKSVDIWACGVILYILLVGYPPF-WDEDQHRLYSQIKA---------------GAYDY 235 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P+W + + ++L++QML +PNKRI+A AL HP+ Sbjct: 236 PSPEWD---------TVTPEAKNLINQMLTVNPNKRITAAEALKHPWI 274 >3RP9-A nrPDB Length = 458 Score = 277 bits (708), Expect = 6e-75, Method: Composition-based stats. Identities = 122/354 (34%), Positives = 170/354 (48%), Gaps = 67/354 (18%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ IG G+YG V +A +KL VVA+KKI E +REI++L LNH Sbjct: 53 DRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHD 112 Query: 62 NIVKLLDVIHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 ++VK+LD++ ++ +LY+V E D KK + IK+ L+ LL G+ Sbjct: 113 HVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFR--TPVYLTELHIKTLLYNLLVGVK 170 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV-------------------- 156 + HS +LHRDLKP N L+N + ++K+ DFGLAR P Sbjct: 171 YVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTF 230 Query: 157 -------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT----------- 198 R T VVT WYRAPE++L + Y+ A+D+WS+GCIFAE++ Sbjct: 231 PHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHAD 290 Query: 199 RRALFPGDS--------------------EIDQLFRIFRTLGTPDEVVWPGVTS--MPDY 236 R LFPG S DQL IF LGTP E + Y Sbjct: 291 RGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRY 350 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 FPK D ++ P D LL +ML ++PNKRI+ LAHPFF++V Sbjct: 351 IRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVR 404 >2VN9-A nrPDB Length = 301 Score = 276 bits (706), Expect = 9e-75, Method: Composition-based stats. Identities = 80/288 (27%), Positives = 130/288 (45%), Gaps = 30/288 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + +Q E++G+G + VV + TG+ A K I + RE + + L HP Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 63 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L D I E YLVF+ + + F D A + Q+L+ + CH + Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGG-ELFEDIVAREYYSEADASHCIQQILESVNHCHLN 122 Query: 122 RVLHRDLKPQNLLINTEGA---IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 ++HRDLKP+NLL+ ++ +KLADFGLA + + T Y +PE+L Sbjct: 123 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK-D 181 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y VD+W+ G I ++ F D + +L++ + Y Sbjct: 182 PYGKPVDMWACGVILYILLVGYPPF-WDEDQHRLYQQIKA---------------GAYDF 225 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P+W + + + L+++ML +P KRI+A AL HP+ Sbjct: 226 PSPEWD---------TVTPEAKDLINKMLTINPAKRITASEALKHPWI 264 >2BDW-A nrPDB Length = 362 Score = 272 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 84/288 (29%), Positives = 133/288 (46%), Gaps = 31/288 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +N+ E++G+G + VV + +K TG A K I + RE + ++L HP Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 88 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L D I E+ YLVF+ + + F D A + Q+L+ +A+CHS+ Sbjct: 89 NIVRLHDSIQEESFHYLVFDLVTGG-ELFEDIVAREFYSEADASHCIQQILESIAYCHSN 147 Query: 122 RVLHRDLKPQNLLINTEGA---IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 ++HR+LKP+NLL+ ++ +KLADFGLA + T Y +PE+L Sbjct: 148 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSPEVLKK-D 205 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 YS VDIW+ G I ++ F D + +L+ + Y Sbjct: 206 PYSKPVDIWACGVILYILLVGYPPF-WDEDQHRLYAQIKA---------------GAYDY 249 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P+W + + +SL+ ML +P KRI+A AL P+ Sbjct: 250 PSPEWD---------TVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 288 >5U6Y-A nrPDB Length = 461 Score = 272 bits (696), Expect = 1e-73, Method: Composition-based stats. Identities = 80/287 (27%), Positives = 129/287 (44%), Gaps = 30/287 (10%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 +Q E++G+G + VV + L G+ A K I + RE + + L HPNI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 V+L D I E YL+F+ + + F D A + Q+L+ + CH V Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGG-ELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 120 Query: 124 LHRDLKPQNLLINTEGA---IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 +HRDLKP+NLL+ ++ +KLADFGLA + + T Y +PE+L Y Sbjct: 121 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-DPY 179 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VD+W+ G I ++ F D + +L++ + Y Sbjct: 180 GKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKA---------------GAYDFPS 223 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 P+W + + + L+++ML +P+KRI+A AL HP+ Sbjct: 224 PEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 261 >2V7O-A nrPDB Length = 336 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 81/288 (28%), Positives = 130/288 (45%), Gaps = 30/288 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +++Q E++G+G + VV + K + A K I + RE + + L HP Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 90 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L D I E YLVF+ + + F D A + Q+L+ + H H Sbjct: 91 NIVRLHDSISEEGFHYLVFDLVTGG-ELFEDIVAREYYSEADASHCIHQILESVNHIHQH 149 Query: 122 RVLHRDLKPQNLLINTEGA---IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 ++HRDLKP+NLL+ ++ +KLADFGLA + + T Y +PE+L Sbjct: 150 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRK-D 208 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y VDIW+ G I ++ F D + +L++ + Y Sbjct: 209 PYGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQIKA---------------GAYDF 252 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P+W + + ++L++QML +P KRI+A AL HP+ Sbjct: 253 PSPEWD---------TVTPEAKNLINQMLTINPAKRITADQALKHPWV 291 >4E7W-A nrPDB Length = 394 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 107/298 (35%), Positives = 168/298 (56%), Gaps = 21/298 (7%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 + + IG G++GVV++A+ + E VA+KK+ D + RE+ +++ + HPN+ Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN------RELQIMRIVKHPNV 94 Query: 64 VKLLDVIHTENK------LYLVFEFLHQDLKKFMD--ASALTGIPLPLIKSYLFQLLQGL 115 V L ++ L LV E++ + + + A +P+ LIK Y++QLL+ L Sbjct: 95 VDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSL 154 Query: 116 AFCHSHRVLHRDLKPQNLLINT-EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 A+ HS + HRD+KPQNLL++ G +KL DFG A+ + + + +YRAPE++ Sbjct: 155 AYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKIL-IAGEPNVSYICSRYYRAPELI 213 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 G Y+T +DIWS GC+ AE++ + LFPG+S IDQL I + LGTP T P Sbjct: 214 FGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIK--TMNP 271 Query: 235 DY-KPSFPKWARQDFSKVV-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 +Y + FP+ FSKV P D L+S++L Y P+ R++A AL HPFF ++ Sbjct: 272 NYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDELR 329 >3N9X-A nrPDB Length = 432 Score = 270 bits (692), Expect = 4e-73, Method: Composition-based stats. Identities = 117/348 (33%), Positives = 164/348 (47%), Gaps = 59/348 (16%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +N+ IG G+YG VY A +K T + VA+KK+ E +REI++L L Sbjct: 26 DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 85 Query: 62 NIVKLLDVIHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 I++L D+I ++ +LY+V E DLKK + IK+ L+ LL G Sbjct: 86 YIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIF--LTEEHIKTILYNLLLGEN 143 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT------------------ 158 F H ++HRDLKP N L+N + ++K+ DFGLAR T Sbjct: 144 FIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKN 203 Query: 159 ----YTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMV-----------TRRALF 203 T VVT WYRAPE++L + Y+ ++DIWS GCIFAE++ R LF Sbjct: 204 LKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLF 263 Query: 204 PGD-----------------SEIDQLFRIFRTLGTPDEVVWPGVTSMP--DYKPSFPKWA 244 PG S DQL IF +GTP E + Y FP Sbjct: 264 PGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHRK 323 Query: 245 RQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 + + P + +DG +LL ML ++PNKRI+ AL HP+ +DV K Sbjct: 324 PINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRKK 371 >3COM-A nrPDB Length = 314 Score = 270 bits (692), Expect = 4e-73, Method: Composition-based stats. Identities = 83/287 (28%), Positives = 135/287 (47%), Gaps = 31/287 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E F +EK+GEG+YG VYKA +K TG++VA+K++ + E I+EIS++++ + P Sbjct: 29 EVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV----ESDLQEIIKEISIMQQCDSP 84 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 ++VK L++V E+ + + I + L L+GL + H Sbjct: 85 HVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFM 144 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 R +HRD+K N+L+NTEG KLADFG+A + + T ++ APE++ Y+ Sbjct: 145 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-YN 203 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 DIWSLG EM + + ++I + IF P P ++ P Sbjct: 204 CVADIWSLGITAIEMAEGKPPY---ADIHPMRAIFMIPTNPP----------PTFRK--P 248 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + +F+ + Q L P +R +A L HPF + Sbjct: 249 ELWSDNFT-----------DFVKQCLVKSPEQRATATQLLQHPFVRS 284 >2VZ6-A nrPDB Length = 313 Score = 270 bits (690), Expect = 7e-73, Method: Composition-based stats. Identities = 80/287 (27%), Positives = 129/287 (44%), Gaps = 30/287 (10%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 +Q E++G+G + VV + L G+ A K I + RE + + L HPNI Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 V+L D I E YL+F+ + + F D A + Q+L+ + CH V Sbjct: 84 VRLHDSISEEGHHYLIFDLVTGG-ELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 142 Query: 124 LHRDLKPQNLLINTEGA---IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 +HRDLKP+NLL+ ++ +KLADFGLA + + T Y +PE+L Y Sbjct: 143 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-DPY 201 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VD+W+ G I ++ F D + +L++ + Y Sbjct: 202 GKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKA---------------GAYDFPS 245 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 P+W + + + L+++ML +P+KRI+A AL HP+ Sbjct: 246 PEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 283 >3KK8-A nrPDB Length = 284 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 83/288 (28%), Positives = 131/288 (45%), Gaps = 31/288 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +N+ E++G+G + VV + +K TG A K I + RE + ++L HP Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 65 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L D I E+ YLVF+ + + F D A + Q+L+ +A+CHS+ Sbjct: 66 NIVRLHDSIQEESFHYLVFDLVTGG-ELFEDIVAREFYSEADASHCIQQILESIAYCHSN 124 Query: 122 RVLHRDLKPQNLLINTEGA---IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 ++HR+LKP+NLL+ ++ +KLADFGLA + T Y +PE+L Sbjct: 125 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSPEVLKK-D 182 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 YS VDIW+ G I ++ F + + +I Y Sbjct: 183 PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI----------------KAGAYDY 226 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P+W + + +SL+ ML +P KRI+A AL P+ Sbjct: 227 PSPEWD---------TVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 265 >3NIE-A nrPDB Length = 429 Score = 268 bits (687), Expect = 1e-72, Method: Composition-based stats. Identities = 115/351 (32%), Positives = 163/351 (46%), Gaps = 62/351 (17%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +N++ IG G+YG VY A +K + VA+KK+ E +REI++L L Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 62 NIVKLLDVIHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 I++L D+I E+ +LY+V E DLKK + +K+ L+ LL G Sbjct: 88 YIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIF--LTEQHVKTILYNLLLGEK 145 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--------------------- 155 F H ++HRDLKP N L+N + ++K+ DFGLAR Sbjct: 146 FIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPH 205 Query: 156 ----VRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMV-----------TRR 200 + T VVT WYRAPE++L + Y+ ++DIWS GCIFAE++ R Sbjct: 206 NKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRF 265 Query: 201 ALFPGD-----------------SEIDQLFRIFRTLGTPDEVVWPGVTSMP--DYKPSFP 241 LFPG S DQL IF +GTP E +T Y FP Sbjct: 266 PLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFP 325 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 D SK + ++G LL ML ++ KRI+ AL+HP+ +DV K Sbjct: 326 TRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKE 376 >3MN3-A nrPDB Length = 271 Score = 268 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 82/286 (28%), Positives = 134/286 (46%), Gaps = 33/286 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS-TAIREISLLKELNHP 61 N+Q V+ +GEG++G V A + TG+ VALK I + REIS L+ L HP Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +I+KL DVI +++++ +V E+ +L ++ + + + Q++ + +CH H Sbjct: 65 HIIKLYDVIKSKDEIIMVIEYAGNELFDYI--VQRDKMSEQEARRFFQQIISAVEYCHRH 122 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 +++HRDLKP+NLL++ +K+ADFGL+ + Y APE++ G Y Sbjct: 123 KIVHRDLKPENLLLDEHLNVKIADFGLSNIMT-DGNFLKTSCGSPNYAAPEVISGKLYAG 181 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 VD+WS G I M+ RR F +S I GV ++P + Sbjct: 182 PEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISN-----------GVYTLPKF----- 225 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 L L+ +ML +P RIS + +F+ Sbjct: 226 -------------LSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK 258 >4O2Z-A nrPDB Length = 377 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 93/297 (31%), Positives = 153/297 (51%), Gaps = 9/297 (3%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + ++ +G G YG+ + TGE V++KK R +REI +++ +H N Sbjct: 46 KYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHEN 105 Query: 63 IVKLLDV-------IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 ++ ++++ H+ +Y+V + D+ + + + + ++ +++Q+L+GL Sbjct: 106 LLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQV--LEESHMQYFVYQILRGL 163 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 + HS V HRDLKP NL+ N +K+ DFGL+R+ VP T V+T WYR PE+LL Sbjct: 164 KYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLL 223 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 YSTAVDIWS+GCIFAEM R+ +FPG + +DQL I + +G P + ++ Sbjct: 224 ENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREALEK 283 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 + +G LS+M DP+KR +A LAHP+ + Sbjct: 284 LNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHDE 340 >3BHH-A nrPDB Length = 295 Score = 268 bits (685), Expect = 2e-72, Method: Composition-based stats. Identities = 83/288 (28%), Positives = 128/288 (44%), Gaps = 30/288 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + +Q E IG+G + VV + TG A K I + RE + + L H Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L D I E YLVF+ + + F D A + Q+L+ + CH Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGG-ELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 122 Query: 122 RVLHRDLKPQNLLINTEGA---IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 V+HRDLKP+NLL+ ++ +KLADFGLA + + T Y +PE+L + Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK-E 181 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y VDIW+ G I ++ F D + +L++ + Y Sbjct: 182 AYGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQIKA---------------GAYDF 225 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P+W + + ++L++QML +P KRI+A AL HP+ Sbjct: 226 PSPEWD---------TVTPEAKNLINQMLTINPAKRITAHEALKHPWV 264 >5ES1-A nrPDB Length = 328 Score = 268 bits (685), Expect = 2e-72, Method: Composition-based stats. Identities = 85/286 (29%), Positives = 134/286 (46%), Gaps = 33/286 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 N++ + IG+G + V AR+ LTG VA+K I RE+ ++K LNHPN Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPN 75 Query: 63 IVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 IVKL +VI TE LYLV E+ ++ ++ + + ++ Q++ + +CH Sbjct: 76 IVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGR--MKEKEARAKFRQIVSAVHYCHQK 133 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 ++HRDLK +NLL++ E IK+ADFG + F + + T + Y APE+ G KY Sbjct: 134 NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDT-FCGSPPYAAPELFQGKKYDG 192 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 VDIWSLG I +V+ F G + + R+ R G +P Y Sbjct: 193 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLR-----------GKYRVPFY----- 236 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 + D S+L + L +P KR + + + + Sbjct: 237 -------------MSTDCESILRRFLVLNPAKRCTLEQIMKDKWIN 269 >4LG4-A nrPDB Length = 299 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 88/297 (29%), Positives = 143/297 (48%), Gaps = 34/297 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E F +EK+GEG+YG V+KA +K +G+VVA+K++ + E I+EIS++++ + P Sbjct: 11 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCDSP 66 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +VK L++V E+ + + T I I + L L+GL + H Sbjct: 67 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLI-EDEIATILKSTLKGLEYLHF 125 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 R +HR++K N+L+NTEG KLADFG+A + + T ++ APE++ Y Sbjct: 126 MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-Y 184 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 + DIWSLG EM + + ++I + IF P P ++ Sbjct: 185 NCVADIWSLGITSIEMAEGKPPY---ADIHPMRAIFMIPTNPP----------PTFRK-- 229 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR 297 P+ DF+ + + L +P +R +A L HPF ++ KPV LR Sbjct: 230 PELWSDDFT-----------DFVKKCLVKNPEQRATATQLLQHPFIKN-AKPVSILR 274 >3Q5I-A nrPDB Length = 504 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 84/308 (27%), Positives = 133/308 (43%), Gaps = 43/308 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL-----------DTETEGVPSTAIR 50 E++ KV K+G G YG V + K A+K I+ + E Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95 Query: 51 EISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ 110 EISLLK L+HPNI+KL DV + YLV EF + F + + Q Sbjct: 96 EISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGG-ELFEQIINRHKFDECDAANIMKQ 154 Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEG---AIKLADFGLARAFGVPVRTYTHEVVTLW 167 +L G+ + H H ++HRD+KP+N+L+ + IK+ DFGL+ F + + T + Sbjct: 155 ILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYK-LRDRLGTAY 213 Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227 Y APE+L K Y+ D+WS G I ++ F G ++ D + ++ + Sbjct: 214 YIAPEVLK--KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKG--------- 262 Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 Y F W + ++ + L+ ML YD NKR +A+ AL + + Sbjct: 263 -------KYYFDFNDWKN---------ISDEAKELIKLMLTYDYNKRCTAEEALNSRWIK 306 Query: 288 DVTKPVPH 295 + Sbjct: 307 KYANNINK 314 >4YZB-A nrPDB Length = 491 Score = 267 bits (682), Expect = 6e-72, Method: Composition-based stats. Identities = 78/291 (26%), Positives = 142/291 (48%), Gaps = 35/291 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNH 60 + ++ +G+G++G V ++K+TG+ A+K I + + + ++E+ LLK+L+H Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDH 89 Query: 61 PNIVKLLDVIHTENKLYLVFE-FLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 PNI+KL + + YLV E + +L + + + Q+L G+ + H Sbjct: 90 PNIMKLYEFFEDKGYFYLVTEVYTGGELFD--EIISRKRFSEVDAARIIRQVLSGITYMH 147 Query: 120 SHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 ++++HRDLKP+NLL+ + I++ DFGL+ F + ++ T +Y APE+L G Sbjct: 148 KNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFEST-KKMKDKIGTAYYIAPEVLHG 206 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 Y D+WS G I +++ F G +E D L ++ + + Sbjct: 207 T--YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKG----------------KF 248 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 P+W + + E + L+ +ML Y P RISA+ AL H + + Sbjct: 249 TFDLPQWKK---------VSEPAKDLIRKMLAYVPTMRISARDALEHEWLK 290 >4RGJ-A nrPDB Length = 520 Score = 265 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 83/309 (26%), Positives = 145/309 (46%), Gaps = 42/309 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNH 60 E ++ ++ +G+G++G V +R+K TG A+K I + + + + +RE+ LLK L+H Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDH 119 Query: 61 PNIVKLLDVIHTENKLYLVFE-FLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 NI+KL + N YLV + + +L + + + Q+L G+ + H Sbjct: 120 INIMKLYEFFEDNNYYYLVSDVYTGGELFD--EIISRKRFYEIDAARIIKQILSGITYMH 177 Query: 120 SHRVLHRDLKPQNLLI----NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 + V+HRDLKP+N+L+ + IK+ DFGL+ F + ++ T +Y AP++L Sbjct: 178 KNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEY-SKKMKDKIGTAYYIAPDVLH 236 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 G Y DIWS G I +++ F G +E D L ++ Sbjct: 237 GT--YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV----------------EAGK 278 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP--- 292 Y P++ + + + + L+ +ML Y RISA+ AL H + + +T Sbjct: 279 YTFDLPQFKK---------ISDKAKDLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNL 329 Query: 293 ---VPHLRL 298 +P L L Sbjct: 330 NIDIPSLEL 338 >6AO5-A nrPDB Length = 362 Score = 265 bits (678), Expect = 1e-71, Method: Composition-based stats. Identities = 86/296 (29%), Positives = 141/296 (47%), Gaps = 32/296 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E F +EK+GEG+YG V+KA +K +G+VVA+K++ + E I+EIS++++ + P Sbjct: 10 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCDSP 65 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +VK L++V E+ + + I + L L+GL + H Sbjct: 66 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFM 125 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 R +HR++K N+L+NTEG KLADFG+A + + T ++ APE++ Y+ Sbjct: 126 RKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-YN 184 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 DIWSLG EM + + ++I + IF P P ++ P Sbjct: 185 CVADIWSLGITSIEMAEGKPPY---ADIHPMRAIFMIPTNPP----------PTFRK--P 229 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR 297 + DF+ + + L +P +R +A L HPF ++ KPV LR Sbjct: 230 ELWSDDFT-----------DFVKKCLVKNPEQRATATQLLQHPFIKN-AKPVSILR 273 >3SOA-A nrPDB Length = 444 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 79/289 (27%), Positives = 129/289 (44%), Gaps = 30/289 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E +Q E++G+G + VV + L G+ A I + RE + + L HP Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L D I E YL+F+ + + F D A + Q+L+ + CH Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGG-ELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 129 Query: 122 RVLHRDLKPQNLLINTEGA---IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 V+HR+LKP+NLL+ ++ +KLADFGLA + + T Y +PE+L Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-D 188 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y VD+W+ G I ++ F D + +L++ + Y Sbjct: 189 PYGKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKA---------------GAYDF 232 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 P+W + + + L+++ML +P+KRI+A AL HP+ Sbjct: 233 PSPEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272 >2JC6-A nrPDB Length = 334 Score = 264 bits (676), Expect = 2e-71, Method: Composition-based stats. Identities = 78/287 (27%), Positives = 130/287 (45%), Gaps = 34/287 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 F+ E +G G + V A K TG++ A+K I +G S+ EI++L+++ H NI Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKAL-KGKESSIENEIAVLRKIKHENI 82 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGI-PLPLIKSYLFQLLQGLAFCHSHR 122 V L D+ + N LYLV + + + D G + + Q+L + + H Sbjct: 83 VALEDIYESPNHLYLVMQLVSGG--ELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 140 Query: 123 VLHRDLKPQNLLI---NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 ++HRDLKP+NLL + E I ++DFGL++ G + T Y APE+L K Sbjct: 141 IVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD-VMSTACGTPGYVAPEVL-AQKP 198 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 YS AVD WS+G I ++ F +++ +I + +Y+ Sbjct: 199 YSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKA----------------EYEFD 242 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P W + + + + ++ DPNKR + + A HP+ Sbjct: 243 SPYWD---------DISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 280 >4UZD-A nrPDB Length = 287 Score = 264 bits (676), Expect = 3e-71, Method: Composition-based stats. Identities = 82/298 (27%), Positives = 144/298 (48%), Gaps = 34/298 (11%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59 +E+F+ +G+G +G VY AR K + ++ALK + + E GV RE+ + L Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 66 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 HPNI++L H ++YL+ E+ + + L+ +Y+ +L L++CH Sbjct: 67 HPNILRLYGYFHDATRVYLILEYAPLGTV-YRELQKLSKFDEQRTATYITELANALSYCH 125 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 S RV+HRD+KP+NLL+ + G +K+ADFG + P T TL Y PE++ G + Sbjct: 126 SKRVIHRDIKPENLLLGSAGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEG-RM 182 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 + VD+WSLG + E + + F ++ + RI R + + Sbjct: 183 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRV------------------EFT 224 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR 297 FP + + E R L+S++L ++P++R + L HP+ + + + Sbjct: 225 FPDF-----------VTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQ 271 >3PG1-A nrPDB Length = 362 Score = 264 bits (676), Expect = 3e-71, Method: Composition-based stats. Identities = 98/307 (31%), Positives = 154/307 (50%), Gaps = 20/307 (6%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTET---------EGVPSTAIREISL 54 + I G+YG V + G VA+K++ + +REI L Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 55 LKELNHPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF 109 L +HPNI+ L D+ +KLYLV E + DL + + + I I+ +++ Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIV-ISPQHIQYFMY 141 Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYR 169 +L GL H V+HRDL P N+L+ I + DF LAR TH V WYR Sbjct: 142 HILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANK-THYVTHRWYR 200 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP---DEVV 226 APE+++ K ++ VD+WS GC+ AEM R+ALF G + +QL +I +GTP D V+ Sbjct: 201 APELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVM 260 Query: 227 WPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 + ++ + S + ++ VVP D L+++ML ++P +RIS + AL HP+F Sbjct: 261 FSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYF 320 Query: 287 QDVTKPV 293 + + P+ Sbjct: 321 ESLFDPL 327 >2QNJ-A nrPDB Length = 328 Score = 263 bits (674), Expect = 4e-71, Method: Composition-based stats. Identities = 87/290 (30%), Positives = 135/290 (46%), Gaps = 31/290 (10%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 N++ ++ IG+G + V AR+ LTG VA+K I RE+ ++K LNHPN Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 72 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 IVKL +VI TE LYL+ E+ + F A + +S Q++ + +CH R Sbjct: 73 IVKLFEVIETEKTLYLIMEYASGG-EVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 131 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182 ++HRDLK +NLL++ + IK+ADFG + F V + T + Y APE+ G KY Sbjct: 132 IVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDT-FCGSPPYAAPELFQGKKYDGP 190 Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPK 242 VD+WSLG I +V+ F G + + R+ R G +P Y Sbjct: 191 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR-----------GKYRIPFY------ 233 Query: 243 WARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 + D +LL + L +P KR + + + + + Sbjct: 234 ------------MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEE 271 >5Y86-A nrPDB Length = 588 Score = 263 bits (672), Expect = 8e-71, Method: Composition-based stats. Identities = 91/333 (27%), Positives = 157/333 (47%), Gaps = 46/333 (13%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN--- 59 ++ ++ IG+G++G V + + + VALK +R + + A EI +L+ L Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE---KRFHRQAAEEIRILEHLKKQD 264 Query: 60 ---HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 N++ +L+ N + + FE L DL + + + G + L++ + +LQ L Sbjct: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 Query: 117 FCHSHRVLHRDLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 H ++++H DLKP+N+L+ G K+ DFG + + + + +YRAPEI+ Sbjct: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEII 381 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 LG + YST +DIWS GCI AE++T + LFPG+ E DQL + LG P + Sbjct: 382 LGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 Query: 235 DYKPS--FPKW----------------ARQDFSKVVPPLDED------------GRSLLS 264 + S P++ + K PP +D L Sbjct: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 Query: 265 QMLHYDPNKRISAKAALAHPFF-QDVTKPVPHL 296 + LH+DP+ R++ AL HP+ + V +P+ + Sbjct: 501 RCLHWDPSARLTPAQALRHPWISKSVPRPLTTI 533 >5IG1-A nrPDB Length = 344 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 77/287 (26%), Positives = 120/287 (41%), Gaps = 31/287 (10%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 IG+G + V++ NK TGEV A+K I L + + REI + L H +IV + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRR 83 Query: 69 VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 128 E+ YLVFE++ + F + + + Q+L L CHS ++HRDL Sbjct: 84 AFRDESHFYLVFEYVSGG-ELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHRDL 142 Query: 129 KPQNLLI---NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVD 185 KP+NLL+ + +K+ DFGLA TY T Y +PE++ Y TAVD Sbjct: 143 KPENLLLASKDPNAPVKITDFGLAVIMEQGP-TYFGFAGTPGYLSPEVIRRV-PYDTAVD 200 Query: 186 IWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR 245 +W+ G I ++ F + +I Y P+W Sbjct: 201 VWACGVILYILLVGYPPFWEEDHQKLYAQIKNC----------------QYDFPSPEWD- 243 Query: 246 QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 + + L+ ML +P +R + + L HP+ P Sbjct: 244 --------SVTTAAKELIKAMLEPNPKRRPTVQELLQHPWIARRDVP 282 >5XZW-A nrPDB Length = 471 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 90/306 (29%), Positives = 138/306 (45%), Gaps = 45/306 (14%) Query: 2 ENFQKV-EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++F + E +G+G + V KA + TG+ A+K I G RE+ +L++LNH Sbjct: 195 KDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVI-GNMDGVTRELEVLQKLNH 253 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 P IV+L Y+V EF+ DL F+ A G + Q+L + + H Sbjct: 254 PRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVG--EDAGREISRQILTAIKYIH 311 Query: 120 SHRVLHRDLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 S + HRDLKP N+LI + +K+ DFGLA+ G TL Y APE++ G Sbjct: 312 SMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGS-FMKTFCGTLAYVAPEVIRGK 370 Query: 178 ------------KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEV 225 YS+ VD+WS+GC+ ++T F G S DQL++ Sbjct: 371 DTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG-STQDQLYKQI--------- 420 Query: 226 VWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 + S+ + +DF + E+ R + +L DPN R +A AL HP+ Sbjct: 421 ----------GRGSYHEGPLKDFR-----ISEEARDFIDSLLQVDPNNRSTAAKALNHPW 465 Query: 286 FQDVTK 291 D + Sbjct: 466 IVDSSN 471 >6FD3-A nrPDB Length = 300 Score = 262 bits (670), Expect = 1e-70, Method: Composition-based stats. Identities = 90/295 (30%), Positives = 142/295 (48%), Gaps = 32/295 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + + + EKIG+G G VY A + TG+ VA+K++ L + + I EI +++E +P Sbjct: 22 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNP 79 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV LD ++L++V E+L D T + I + + LQ L F HS+ Sbjct: 80 NIVNYLDSYLVGDELWVVMEYLAGG--SLTDVVTETCMDEGQIAAVCRECLQALDFLHSN 137 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 +V+HRD+K N+L+ +G++KL DFG + V T ++ APE++ K Y Sbjct: 138 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYG 196 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 VDIWSLG + EMV + ++ + L+ I T GTP+ Sbjct: 197 PKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPE------------------ 237 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296 + L R L++ L D ++R SAK L HPF + + KP+ L Sbjct: 238 -------LQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK-LDKPLSSL 284 >3E3P-A nrPDB Length = 360 Score = 262 bits (670), Expect = 1e-70, Method: Composition-based stats. Identities = 109/315 (34%), Positives = 161/315 (51%), Gaps = 27/315 (8%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-- 58 M+ FQ G+GT+G V + K TG VA+KK+ D RE+ ++++L Sbjct: 22 MDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRN------RELQIMQDLAV 75 Query: 59 -NHPNIVKLLDVIHTENK-------LYLVFEFLHQDLKKFMDASALTGIPLP--LIKSYL 108 +HPNIV+L +T + L +V E++ L + + P LIK +L Sbjct: 76 LHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFL 135 Query: 109 FQLLQGLAFCH--SHRVLHRDLKPQNLLINT-EGAIKLADFGLARAFGVPVRTYTHEVVT 165 FQL++ + H S V HRD+KP N+L+N +G +KL DFG A+ P + + Sbjct: 136 FQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLS-PSEPNVAYICS 194 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEV 225 +YRAPE++ G ++Y+TAVDIWS+GCIFAEM+ +F GD+ QL I R LG P Sbjct: 195 RYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSRE 254 Query: 226 VW----PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281 V P T + Y W+ FS ++ LLS +L Y P +R+ AL Sbjct: 255 VLRKLNPSHTDVDLYNSKGIPWSNV-FSDHSLKDAKEAYDLLSALLQYLPEERMKPYEAL 313 Query: 282 AHPFFQDVTKPVPHL 296 HP+F ++ P L Sbjct: 314 CHPYFDELHDPATKL 328 >5YKS-A nrPDB Length = 377 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 92/293 (31%), Positives = 140/293 (47%), Gaps = 34/293 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 + + +G G + VV AR+ TGE VA+K I +E+ +K + HPNI Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 64 VKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 V+L +VI T+ KLYL+ E D+ ++ G+ L K Y Q++ +++CH Sbjct: 97 VRLYEVIDTQTKLYLILELGDGGDMFDYIMKHE-EGLNEDLAKKYFAQIVHAISYCHKLH 155 Query: 123 VLHRDLKPQN-LLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 V+HRDLKP+N + +G +KL DFG + F P + T +L Y APEILLG +Y + Sbjct: 156 VVHRDLKPENVVFFEKQGLVKLTDFGFSNKF-QPGKKLTTSCGSLAYSAPEILLGDEYDA 214 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 AVDIWSLG I +V + F ++ + L I T Sbjct: 215 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYT-------------------- 254 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 V + ++ + L+++ML DP +R S + HP+ Q V P P Sbjct: 255 ---------VPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGV-DPSP 297 >3D2K-A nrPDB Length = 272 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 82/294 (27%), Positives = 143/294 (48%), Gaps = 35/294 (11%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59 +E+F +G+G +G VY AR + + ++ALK + + E GV RE+ + L Sbjct: 11 LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLR 70 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 HPNI++L H ++YL+ E+ + + L+ +Y+ +L L++CH Sbjct: 71 HPNILRLYGYFHDATRVYLILEYAPLGTV-YRELQKLSRFDEQRTATYITELANALSYCH 129 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 S RV+HRD+KP+NLL+ + G +K+ADFG + P T TL Y PE++ G + Sbjct: 130 SKRVIHRDIKPENLLLGSNGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEG-RM 186 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 + VD+WSLG + E + F + + RI R + + Sbjct: 187 HDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRV------------------EFT 228 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ-DVTKP 292 FP + + E R L+S++L ++ ++R++ L HP+ + + +KP Sbjct: 229 FPDF-----------VTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKP 271 >4FG9-A nrPDB Length = 320 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 75/287 (26%), Positives = 130/287 (45%), Gaps = 34/287 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 + + +G G + V A +K T ++VA+K I + EG + EI++L ++ HPNI Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEAL-EGKEGSMENEIAVLHKIKHPNI 78 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGI-PLPLIKSYLFQLLQGLAFCHSHR 122 V L D+ + LYL+ + + + D G +FQ+L + + H Sbjct: 79 VALDDIYESGGHLYLIMQLVSGG--ELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136 Query: 123 VLHRDLKPQNLL---INTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 ++HRDLKP+NLL ++ + I ++DFGL++ P + T Y APE+L K Sbjct: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLSK-MEDPGSVLSTACGTPGYVAPEVL-AQKP 194 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 YS AVD WS+G I ++ F +++ +I + +Y+ Sbjct: 195 YSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKA----------------EYEFD 238 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P W + + + + ++ DP KR + + AL HP+ Sbjct: 239 SPYWD---------DISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276 >5KZ7-A nrPDB Length = 346 Score = 261 bits (668), Expect = 2e-70, Method: Composition-based stats. Identities = 86/301 (28%), Positives = 137/301 (45%), Gaps = 40/301 (13%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 N++ ++ IG+G + V AR+ LTG+ VA+K I RE+ ++K LNHPN Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 93 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 IVKL +VI TE LYLV E+ + F A + ++ Q++ + +CH Sbjct: 94 IVKLFEVIETEKTLYLVMEYASGG-EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 152 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182 ++HRDLK +NLL++ + IK+ADFG + F + Y APE+ G KY Sbjct: 153 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFG-NKLDTFCGSPPYAAPELFQGKKYDGP 211 Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPK 242 VD+WSLG I +V+ F G + + R+ R G +P Y Sbjct: 212 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR-----------GKYRIPFY------ 254 Query: 243 WARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF---------FQDVTKPV 293 + D +LL + L +P+KR + + + + + +P+ Sbjct: 255 ------------MSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL 302 Query: 294 P 294 P Sbjct: 303 P 303 >3H4J-B nrPDB Length = 336 Score = 260 bits (665), Expect = 5e-70, Method: Composition-based stats. Identities = 85/299 (28%), Positives = 137/299 (45%), Gaps = 37/299 (12%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS-TAIREISLLKELNHPN 62 + E +GEG++G V A + T + VALK I + REIS LK L HP+ Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 I+KL DVI T + +V E+ +L ++ + + + Q++ + +CH H+ Sbjct: 71 IIKLYDVITTPTDIVMVIEYAGGELFDYI--VEKKRMTEDEGRRFFQQIICAIEYCHRHK 128 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182 ++HRDLKP+NLL++ +K+ADFGL+ + Y APE++ G Y Sbjct: 129 IVHRDLKPENLLLDDNLNVKIADFGLSNIMT-DGNFLKTSCGSPNYAAPEVINGKLYAGP 187 Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPK 242 VD+WS G + M+ R F D I LF+ + V MPD+ Sbjct: 188 EVDVWSCGIVLYVMLVGRLPF-DDEFIPNLFKKVNS----------CVYVMPDF------ 230 Query: 243 WARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ----DVTKPVPHLR 297 L +SL+ +M+ DP +RI+ + P+F D +P+ ++ Sbjct: 231 ------------LSPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEEVQ 277 >4JXF-A nrPDB Length = 266 Score = 258 bits (659), Expect = 2e-69, Method: Composition-based stats. Identities = 77/291 (26%), Positives = 130/291 (44%), Gaps = 31/291 (10%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59 +E+F+ +G+G++ VY+A + TG VA+K I + G+ E+ + +L Sbjct: 6 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 65 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 HP+I++L + N +YLV E H + + + ++ Q++ G+ + H Sbjct: 66 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 125 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 SH +LHRDL NLL+ IK+ADFGLA +P + T Y +PEI Sbjct: 126 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSA- 184 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 + D+WSLGC+F ++ R F D+ + L ++ MP + Sbjct: 185 HGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLAD-----------YEMPSF--- 230 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 L + + L+ Q+L +P R+S + L HPF + Sbjct: 231 ---------------LSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNS 266 >3TAC-A nrPDB Length = 361 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 81/296 (27%), Positives = 138/296 (46%), Gaps = 36/296 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEG---VPSTAIREISLLKEL 58 + ++ E IG+G + VV + N+ TG+ A+K + + T RE S+ L Sbjct: 26 DVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHML 85 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGI--PLPLIKSYLFQLLQGL 115 HP+IV+LL+ ++ LY+VFEF+ DL + A G + Y+ Q+L+ L Sbjct: 86 KHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEAL 145 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGA---IKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 +CH + ++HRD+KP +L+ ++ +KL FG+A G V T + APE Sbjct: 146 RYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPE 205 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 ++ + Y VD+W G I +++ F G E R+F + Sbjct: 206 VVK-REPYGKPVDVWGCGVILFILLSGCLPFYGTKE-----RLFEGIIK----------- 248 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 YK + +W+ + E + L+ +ML DP +RI+ AL HP+ ++ Sbjct: 249 -GKYKMNPRQWSH---------ISESAKDLVRRMLMLDPAERITVYEALNHPWLKE 294 >4REW-A nrPDB Length = 540 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 84/288 (29%), Positives = 129/288 (44%), Gaps = 34/288 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHP 61 ++ + +G GT+G V +++LTG VA+K + R + V REI LK HP Sbjct: 7 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 66 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +I+KL VI T + +++V E++ L ++ + + + Q+L G+ +CH Sbjct: 67 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR--LDEKESRRLFQQILSGVDYCHR 124 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 H V+HRDLKP+N+L++ K+ADFGL+ + Y APE++ G Y Sbjct: 125 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYA 183 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VDIWS G I ++ F D + LF+ G+ P Y Sbjct: 184 GPEVDIWSSGVILYALLCGTLPF-DDDHVPTLFKKI----------CDGIFYTPQY---- 228 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 L+ SLL ML DP KR S K H +F+ Sbjct: 229 --------------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ 262 >5WAX-A nrPDB Length = 310 Score = 256 bits (655), Expect = 7e-69, Method: Composition-based stats. Identities = 76/287 (26%), Positives = 124/287 (43%), Gaps = 30/287 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ V IG G +GV RN+ G++VA+K I E + REI + L HP Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYI---ERGEKIDENVQREIINHRSLRHP 67 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NI++ +VI T L +V E+ + F + + QL+ G+++CHS Sbjct: 68 NIIRFKEVILTPTHLAIVMEYASGG-ELFERICNAGRFSEDEARFFFQQLISGVSYCHSM 126 Query: 122 RVLHRDLKPQNLLINTEG--AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 +V HRDLK +N L++ +K+ DFG +++ V V T Y APE+LL +Y Sbjct: 127 QVCHRDLKLENTLLDGSTAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPEVLLKKEY 185 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 D+WS G M+ F E + + + S+PDY Sbjct: 186 DGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRI-------LGVQYSIPDYVH- 237 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 + + + L+S++ +P RI+ HP+F Sbjct: 238 ---------------ISPECQDLISRIFVANPATRITIPEIRNHPWF 269 >4D28-A nrPDB Length = 446 Score = 256 bits (655), Expect = 8e-69, Method: Composition-based stats. Identities = 85/293 (29%), Positives = 137/293 (46%), Gaps = 31/293 (10%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHP 61 ++ IGEGT+ V ARN TG+ VA+K + + + REIS++K + HP Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+L +V+ +++K+Y+V EF+ + F + + Y QL+ +A CHS Sbjct: 70 NIVRLYEVLASKSKIYIVLEFVTGG-ELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHSK 128 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 V HRDLKP+NLL++T G +K++DFGL+ V T Y APE+L G Y Sbjct: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYDG 188 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 +A DIWS G I ++ F ++++ L+R + P Sbjct: 189 SAADIWSCGVILFVILAGYLPF-SETDLPGLYRKINAA-----------------EFDCP 230 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 W + + L+ ++L +P RI + P+F+ P+ Sbjct: 231 PW-----------FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVPIR 272 >4CFF-A nrPDB Length = 571 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 83/288 (28%), Positives = 127/288 (44%), Gaps = 34/288 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHP 61 ++ + +G GT+G V ++LTG VA+K + R + V REI LK HP Sbjct: 34 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 93 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +I+KL VI T ++V E++ L ++ + + Q+L + +CH Sbjct: 94 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAVDYCHR 151 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 H V+HRDLKP+N+L++ K+ADFGL+ + Y APE++ G Y Sbjct: 152 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYA 210 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VDIWS G I ++ F D + LF+ R GV +P+Y Sbjct: 211 GPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRG----------GVFYIPEY---- 255 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 L+ +LL ML DP KR + K H +F+ Sbjct: 256 --------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 289 >2I6L-A nrPDB Length = 320 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 96/310 (30%), Positives = 161/310 (51%), Gaps = 24/310 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + ++ +G G G+V+ A + + VA+KKI L A+REI +++ L+H N Sbjct: 12 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLT--DPQSVKHALREIKIIRRLDHDN 69 Query: 63 IVKLL--------------DVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYL 108 IVK+ + N +Y+V E++ DL ++ + + ++ Sbjct: 70 IVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGP---LLEEHARLFM 126 Query: 109 FQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHE---VV 164 +QLL+GL + HS VLHRDLKP NL IN + +K+ DFGLAR H +V Sbjct: 127 YQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLV 186 Query: 165 TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDE 224 T WYR+P +LL Y+ A+D+W+ GCIFAEM+T + LF G E++Q+ I ++ E Sbjct: 187 TKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHE 246 Query: 225 VVWPGVTS-MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAH 283 + S +P Y + + ++++P + + L Q+L + P R++A+ AL+H Sbjct: 247 EDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSH 306 Query: 284 PFFQDVTKPV 293 P+ + P+ Sbjct: 307 PYMSIYSFPM 316 >4FIE-A nrPDB Length = 423 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 78/300 (26%), Positives = 132/300 (44%), Gaps = 37/300 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++NF KIGEG+ G+V A + +G++VA+KK+ D + E+ ++++ H Sbjct: 153 LDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQH 207 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 N+V++ + ++L++V EFL D T + I + +LQ L+ H+ Sbjct: 208 ENVVEMYNSYLVGDELWVVMEFLEGG--ALTDIVTHTRMNEEQIAAVCLAVLQALSVLHA 265 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 V+HRD+K ++L+ +G +KL+DFG V V T ++ APE++ Y Sbjct: 266 QGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PY 324 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VDIWSLG + EMV + + + + I L Sbjct: 325 GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLP-------------------- 364 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP---VPHLR 297 K + + + L ++L DP +R +A L HPF P VP +R Sbjct: 365 ------PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMR 418 >3DAK-A nrPDB Length = 290 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 74/299 (24%), Positives = 125/299 (41%), Gaps = 32/299 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++++ E IG G VV A E VA+K+I L+ + ++EI + + +HP Sbjct: 10 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKC-QTSMDELLKEIQAMSQCHHP 68 Query: 62 NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTG------IPLPLIKSYLFQLLQG 114 NIV +++L+LV + L + + G + I + L ++L+G Sbjct: 69 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 128 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV-----RTYTHEVVTLWYR 169 L + H + +HRD+K N+L+ +G++++ADFG++ + V T + Sbjct: 129 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 188 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 APE++ + Y DIWS G E+ T A + + L + E Sbjct: 189 APEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQD 248 Query: 230 VTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + Y SF R ++S L DP KR +A L H FFQ Sbjct: 249 KEMLKKYGKSF-------------------RKMISLCLQKDPEKRPTAAELLRHKFFQK 288 >5EZV-A nrPDB Length = 560 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 83/288 (28%), Positives = 127/288 (44%), Gaps = 34/288 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHP 61 ++ + +G GT+G V ++LTG VA+K + R + V REI LK HP Sbjct: 29 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 88 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +I+KL VI T ++V E++ L ++ + + Q+L + +CH Sbjct: 89 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAVDYCHR 146 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 H V+HRDLKP+N+L++ K+ADFGL+ + Y APE++ G Y Sbjct: 147 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYA 205 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VDIWS G I ++ F D + LF+ R GV +P+Y Sbjct: 206 GPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRG----------GVFYIPEY---- 250 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 L+ +LL ML DP KR + K H +F+ Sbjct: 251 --------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 284 >4CZT-A nrPDB Length = 464 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 75/292 (25%), Positives = 130/292 (44%), Gaps = 33/292 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP-STAIREISLLKELNHP 61 ++ +GEGT+ V ARN G+ VA+K I + + + REIS +K + HP Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 71 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 N++++ +V+ ++ K+Y V EF+ + F S+ + + Y QL+ + +CHS Sbjct: 72 NVIRMFEVMASKTKIYFVLEFVTGG-ELFDKISSNGRLKEDEARKYFQQLINAVDYCHSR 130 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGV--PVRTYTHEVVTLWYRAPEILLGCKY 179 V HRDLKP+NLL++ GA+K++DFGL+ T Y APE++ Y Sbjct: 131 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY 190 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 D+WS G I ++ F + +IF+ + + Sbjct: 191 DGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA------------------EFT 232 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 P W + L+ ++L +P RI+ + + +F+ K Sbjct: 233 CPPW-----------FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYK 273 >2UV2-A nrPDB Length = 325 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 83/301 (27%), Positives = 137/301 (45%), Gaps = 34/301 (11%) Query: 2 ENF-QKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 E+F + + ++G+G +G VYKA+NK T + A K I DT++E + EI +L +H Sbjct: 36 EDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVI--DTKSEEELEDYMVEIDILASCDH 93 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 PNIVKLLD + EN L+++ EF + + I+ Q L L + H Sbjct: 94 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 153 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL----G 176 ++++HRDLK N+L +G IKLADFG++ ++ + T ++ APE+++ Sbjct: 154 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 213 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 + Y D+WSLG EM + + L +I ++ P + P Sbjct: 214 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS--EPPTLAQPS------- 264 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ-DVTKPVPH 295 +W + + L + L + + R + L HPF D KP+ Sbjct: 265 -----RW------------SSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRE 307 Query: 296 L 296 L Sbjct: 308 L 308 >4PDS-A nrPDB Length = 347 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 87/302 (28%), Positives = 136/302 (45%), Gaps = 45/302 (14%) Query: 2 ENFQKV-EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++F + E +G+G + V KA + TG+ ++K I G RE+ +L++LNH Sbjct: 30 KDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVI-GNMDGVTRELEVLQKLNH 88 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 P IV+L Y+V EF+ DL F+ A G + Q+L + + H Sbjct: 89 PRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVG--EDAGREISRQILTAIKYIH 146 Query: 120 SHRVLHRDLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 S + HRDLKP N+LI + +K+ FGLA+ G TL Y APE++ G Sbjct: 147 SMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGS-FMKTFCGTLAYVAPEVIRGK 205 Query: 178 ------------KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEV 225 YS+ VD+WS+GC+ ++T F G S DQL++ Sbjct: 206 DTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG-STQDQLYKQI--------- 255 Query: 226 VWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 + S+ + +DF + E+ R + +L DPN R +A AL HP+ Sbjct: 256 ----------GRGSYHEGPLKDFR-----ISEEARDFIDSLLQVDPNNRSTAAKALNHPW 300 Query: 286 FQ 287 + Sbjct: 301 IK 302 >2F57-A nrPDB Length = 317 Score = 253 bits (648), Expect = 4e-68, Method: Composition-based stats. Identities = 80/292 (27%), Positives = 134/292 (45%), Gaps = 34/292 (11%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 KIGEG+ G+V A K TG+ VA+KK+ D + E+ ++++ +H N+V + Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKM--DLRKQQRRELLFNEVVIMRDYHHDNVVDMYS 109 Query: 69 VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 128 ++L++V EFL D T + I + +L+ L++ H+ V+HRD+ Sbjct: 110 SYLVGDELWVVMEFLEGG--ALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDI 167 Query: 129 KPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWS 188 K ++L+ ++G IKL+DFG V V T ++ APE++ Y T VDIWS Sbjct: 168 KSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRL-PYGTEVDIWS 226 Query: 189 LGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDF 248 LG + EM+ + + + + RI + S P + Sbjct: 227 LGIMVIEMIDGEPPYFNEPPLQAMRRI---------------------RDSLPPRVKD-- 263 Query: 249 SKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP---VPHLR 297 + + R L ML +P++R +A+ L HPF + P VP +R Sbjct: 264 ---LHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMR 312 >5KCV-A nrPDB Length = 460 Score = 253 bits (647), Expect = 7e-68, Method: Composition-based stats. Identities = 76/296 (25%), Positives = 125/296 (42%), Gaps = 38/296 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTE-TEGVPSTAIREISLLKELN 59 M F+ ++ +G+GT+G V + K TG A+K ++ + + + + E +L+ Sbjct: 161 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 220 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 HP + L T ++L V E+ + + F S + Y +++ L + H Sbjct: 221 HPFLTALKYSFQTHDRLCFVMEYANGG-ELFFHLSRERVFSEDRARFYGAEIVSALDYLH 279 Query: 120 S-HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 S V++RDLK +NL+++ +G IK+ DFGL + T T Y APE+L Sbjct: 280 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED-N 338 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y AVD W LG + EM+ R F I +E+ +P Sbjct: 339 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM-----EEIRFP---------- 383 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFFQDV 289 L + +SLLS +L DP +R+ AK + H FF + Sbjct: 384 --------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 425 >4L42-A nrPDB Length = 346 Score = 253 bits (646), Expect = 7e-68, Method: Composition-based stats. Identities = 81/299 (27%), Positives = 133/299 (44%), Gaps = 41/299 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLDTETEGVPSTA--IREISLLK 56 E F+ + +G+G YG V++ R TG++ A+K ++ TA E ++L+ Sbjct: 18 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 77 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 E+ HP IV L+ T KLYL+ E+L + FM YL ++ L Sbjct: 78 EVKHPFIVDLIYAFQTGGKLYLILEYLSGG-ELFMQLEREGIFMEDTACFYLAEISMALG 136 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 H +++RDLKP+N+++N +G +KL DFGL + T+ Y APEIL+ Sbjct: 137 HLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMR 196 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 ++ AVD WSLG + +M+T F G++ + +I + Sbjct: 197 SG-HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK----------------- 238 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFFQDVT 290 + P L ++ R LL ++L + R+ A AHPFF+ + Sbjct: 239 ------------LNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHIN 285 >5ZTN-A nrPDB Length = 429 Score = 253 bits (646), Expect = 9e-68, Method: Composition-based stats. Identities = 92/330 (27%), Positives = 154/330 (46%), Gaps = 45/330 (13%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP- 61 ++ ++ IG+G++G V KA + + VALK +R + + A EI +L+ L Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNE---KRFHRQAAEEIRILEHLRKQD 154 Query: 62 -----NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 N++ +L+ N + + FE L +L + + + G LPL++ + +LQ L Sbjct: 155 KDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD 214 Query: 117 FCHSHRVLHRDLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 H +R++H DLKP+N+L+ +G IK+ DFG + V TY + + +YRAPE++ Sbjct: 215 ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTY---IQSRFYRAPEVI 271 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 LG + Y +D+WSLGCI AE++T L PG+ E DQL + LG P + + Sbjct: 272 LGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAK 330 Query: 235 DYKPSF------------------------------PKWARQDFSKVVPPLDEDGRSLLS 264 ++ S P +R+ + + D L Sbjct: 331 NFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLK 390 Query: 265 QMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 Q L +DP R++ AL HP+ + P Sbjct: 391 QCLEWDPAVRMTPGQALRHPWLRRRLPKPP 420 >2J90-A nrPDB Length = 304 Score = 253 bits (646), Expect = 9e-68, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 133/300 (44%), Gaps = 38/300 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGV----PSTAIREISLLKE 57 ++++ E++G G + +V K R K TG+ A K I+ + RE+++L+E Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 85 Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 + HPNI+ L D+ + + L+ E + L F+ + + +L Q+L G+ Sbjct: 86 IRHPNIITLHDIFENKTDVVLILELVSGGELFDFL--AEKESLTEDEATQFLKQILDGVH 143 Query: 117 FCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 + HS R+ H DLKP+N+++ + IKL DFG+A + + T + APE Sbjct: 144 YLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAG-NEFKNIFGTPEFVAPE 202 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 I+ + D+WS+G I +++ + F G+++ + L I DE + Sbjct: 203 IV-NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNT-- 259 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 E + + ++L DP +R++ +L H + + + + Sbjct: 260 -----------------------SELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRR 296 >3EB0-A nrPDB Length = 383 Score = 253 bits (646), Expect = 9e-68, Method: Composition-based stats. Identities = 100/334 (29%), Positives = 171/334 (51%), Gaps = 52/334 (15%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + + + +G G++G+V + + +G+ ALKK+ D + RE+ ++K L+H Sbjct: 7 KKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN------RELDIMKVLDHV 60 Query: 62 NIVKLLDVIHT--------------------------------------ENKLYLVFEFL 83 NI+KL+D +T L ++ E++ Sbjct: 61 NIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYV 120 Query: 84 HQDLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT-EGA 140 L K + + + IP+ LI Y++QL + + F HS + HRD+KPQNLL+N+ + Sbjct: 121 PDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT 180 Query: 141 IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRR 200 +KL DFG A+ +P + + +YRAPE++LG Y+ ++D+WS+GC+F E++ + Sbjct: 181 LKLCDFGSAKKL-IPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGK 239 Query: 201 ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY-KPSFPKWARQDFSKVVPPLDED- 258 LF G++ IDQL RI + +GTP + + P Y + FP +D+ K++P Sbjct: 240 PLFSGETSIDQLVRIIQIMGTPTKEQM--IRMNPHYTEVRFPTLKAKDWRKILPEGTPSL 297 Query: 259 GRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 LL Q+L Y+P+ RI+ A+AHPFF + Sbjct: 298 AIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNS 331 >6CMJ-A nrPDB Length = 321 Score = 252 bits (644), Expect = 1e-67, Method: Composition-based stats. Identities = 82/309 (26%), Positives = 144/309 (46%), Gaps = 43/309 (13%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT---------ETEGVPSTAIRE 51 ++ + ++IG+G+YGVV A N+ A+K + + G +E Sbjct: 33 LDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQE 92 Query: 52 ISLLKELNHPNIVKLLDVIHT--ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF 109 I++LK+L+HPN+VKL++V+ E+ LY+VFE ++Q M+ L + + Y Sbjct: 93 IAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVPTLKPLSEDQARFYFQ 150 Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYR 169 L++G+ + H +++HRD+KP NLL+ +G IK+ADFG++ F ++ V T + Sbjct: 151 DLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFM 210 Query: 170 APEILLGCKYY--STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227 APE L + A+D+W++G V + F DE + Sbjct: 211 APESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF------------------MDERIM 252 Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF- 286 + + FP P + ED + L+++ML +P RI HP+ Sbjct: 253 CLHSKIKSQALEFPDQ---------PDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVT 303 Query: 287 QDVTKPVPH 295 + +P+P Sbjct: 304 RHGAEPLPS 312 >2JDO-A nrPDB Length = 342 Score = 252 bits (644), Expect = 1e-67, Method: Composition-based stats. Identities = 76/296 (25%), Positives = 125/296 (42%), Gaps = 37/296 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTE-TEGVPSTAIREISLLKELN 59 M +F ++ +G+GT+G V R K TG A+K +R + + + + E +L+ Sbjct: 9 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTR 68 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 HP + L T ++L V E+ + + F S + Y +++ L + H Sbjct: 69 HPFLTALKYAFQTHDRLCFVMEYANGG-ELFFHLSRERVFTEERARFYGAEIVSALEYLH 127 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 S V++RD+K +NL+++ +G IK+ DFGL + T T Y APE+L Sbjct: 128 SRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED-ND 186 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 Y AVD W LG + EM+ R F I +E+ +P Sbjct: 187 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILM-----EEIRFP----------- 230 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFFQDVT 290 L + +SLL+ +L DP +R+ AK + H FF + Sbjct: 231 -------------RTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSIN 273 >4JDH-A nrPDB Length = 346 Score = 252 bits (644), Expect = 1e-67, Method: Composition-based stats. Identities = 78/300 (26%), Positives = 132/300 (44%), Gaps = 37/300 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++NF KIGEG+ G+V A + +G++VA+KK+ D + E+ ++++ H Sbjct: 76 LDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQH 130 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 N+V++ + ++L++V EFL D T + I + +LQ L+ H+ Sbjct: 131 ENVVEMYNSYLVGDELWVVMEFLEGG--ALTDIVTHTRMNEEQIAAVCLAVLQALSVLHA 188 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 V+HRD+K ++L+ +G +KL+DFG V V T ++ APE++ Y Sbjct: 189 QGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PY 247 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VDIWSLG + EMV + + + + I L Sbjct: 248 GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLP-------------------- 287 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP---VPHLR 297 K + + + L ++L DP +R +A L HPF P VP +R Sbjct: 288 ------PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMR 341 >3Q53-A nrPDB Length = 306 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 87/295 (29%), Positives = 140/295 (47%), Gaps = 32/295 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + + + EKIG+G G VY A + TG+ VA++++ L + + I EI +++E +P Sbjct: 21 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPK--KELIINEILVMRENKNP 78 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV LD ++L++V E+L D T + I + + LQ L F HS+ Sbjct: 79 NIVNYLDSYLVGDELWVVMEYLAGG--SLTDVVTETCMDEGQIAAVCRECLQALEFLHSN 136 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 +V+HRD+K N+L+ +G++KL DFG + V T ++ APE++ K Y Sbjct: 137 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKAYG 195 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 VDIWSLG + EM+ + ++ + L+ I T GTP+ Sbjct: 196 PKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI-ATNGTPE------------------ 236 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296 + L R L++ L D KR SAK + H F + + KP+ L Sbjct: 237 -------LQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLK-IAKPLSSL 283 >4KS7-A nrPDB Length = 292 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 80/293 (27%), Positives = 131/293 (44%), Gaps = 34/293 (11%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 KIGEG+ G+V AR K +G VA+K + D + E+ ++++ H N+V++ Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMM--DLRKQQRRELLFNEVVIMRDYQHFNVVEMYK 87 Query: 69 VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 128 +L+++ EFL D + + I + +LQ LA+ H+ V+HRD+ Sbjct: 88 SYLVGEELWVLMEFLQGG--ALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDI 145 Query: 129 KPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWS 188 K ++L+ +G +KL+DFG V V T ++ APE++ Y+T VDIWS Sbjct: 146 KSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLYATEVDIWS 204 Query: 189 LGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDF 248 LG + EMV + DS + + R+ + + Sbjct: 205 LGIMVIEMVDGEPPYFSDSPVQAMKRL--------------------------RDSPPPK 238 Query: 249 SKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP---VPHLRL 298 K + R L +ML DP +R +A+ L HPF P VP ++L Sbjct: 239 LKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQL 291 >4XBR-A nrPDB Length = 366 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 78/300 (26%), Positives = 132/300 (44%), Gaps = 37/300 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++NF KIGEG+ G+V A + +G++VA+KK+ D + E+ ++++ H Sbjct: 96 LDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQH 150 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 N+V++ + ++L++V EFL D T + I + +LQ L+ H+ Sbjct: 151 ENVVEMYNSYLVGDELWVVMEFLEGG--ALTDIVTHTRMNEEQIAAVCLAVLQALSVLHA 208 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 V+HRD+K ++L+ +G +KL+DFG V V T ++ APE++ Y Sbjct: 209 QGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PY 267 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VDIWSLG + EMV + + + + I L Sbjct: 268 GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLP-------------------- 307 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP---VPHLR 297 K + + + L ++L DP +R +A L HPF P VP +R Sbjct: 308 ------PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMR 361 >2JAM-A nrPDB Length = 304 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 77/290 (26%), Positives = 126/290 (43%), Gaps = 34/290 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 F +E +G G + V+ + +LTG++ ALK I+ S+ EI++LK++ H NI Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD--SSLENEIAVLKKIKHENI 68 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 V L D+ + YLV + + + F + Q+L + + H + + Sbjct: 69 VTLEDIYESTTHYYLVMQLVSGG-ELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGI 127 Query: 124 LHRDLKPQNLLI---NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 +HRDLKP+NLL I + DFGL++ + + T Y APE+L K Y Sbjct: 128 VHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGI--MSTACGTPGYVAPEVL-AQKPY 184 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 S AVD WS+G I ++ F ++E +I Y+ Sbjct: 185 SKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGY----------------YEFES 228 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 P W + E + + +L DPN+R + + AL+HP+ T Sbjct: 229 PFWD---------DISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNT 269 >2Q0N-A nrPDB Length = 301 Score = 251 bits (642), Expect = 2e-67, Method: Composition-based stats. Identities = 78/300 (26%), Positives = 132/300 (44%), Gaps = 37/300 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++NF KIGEG+ G+V A + +G++VA+KK+ D + E+ ++++ H Sbjct: 31 LDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQH 85 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 N+V++ + ++L++V EFL D T + I + +LQ L+ H+ Sbjct: 86 ENVVEMYNSYLVGDELWVVMEFLEGG--ALTDIVTHTRMNEEQIAAVCLAVLQALSVLHA 143 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 V+HRD+K ++L+ +G +KL+DFG V V T ++ APE++ Y Sbjct: 144 QGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PY 202 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VDIWSLG + EMV + + + + I L Sbjct: 203 GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLP-------------------- 242 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP---VPHLR 297 K + + + L ++L DP +R +A L HPF P VP +R Sbjct: 243 ------PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMR 296 >4CQG-A nrPDB Length = 331 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 89/297 (29%), Positives = 136/297 (45%), Gaps = 35/297 (11%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ ++ E IG G + V A + LTGE+VA+K + + +P EI LK L H Sbjct: 8 LKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPR-VKTEIDALKSLRH 66 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 +I +L V+ T+NK+++V E+ +L ++ + + + Q+L +A+ H Sbjct: 67 QHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQ--DRLSEEETRVVFRQILSAVAYVH 124 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGL-ARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 S HRDLKP+NLL + +KL DFGL A+ G +L Y APE++ G Sbjct: 125 SQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKS 184 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y + D+WS+G + ++ F D+ + +I R K Sbjct: 185 YLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRG------------------KY 226 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF-FQDVTKPVP 294 PKW L LL QML DP KRIS + L HP+ QD + PV Sbjct: 227 EVPKW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPVE 272 >3MV5-A nrPDB Length = 342 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 76/296 (25%), Positives = 125/296 (42%), Gaps = 38/296 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTE-TEGVPSTAIREISLLKELN 59 M F+ ++ +G+GT+G V + K TG A+K ++ + + + + E +L+ Sbjct: 9 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 68 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 HP + L T ++L V E+ + + F S + Y +++ L + H Sbjct: 69 HPFLTALKYSFQTHDRLCFVMEYANGG-ELFFHLSRERVFSEDRARFYGAEIVSALDYLH 127 Query: 120 S-HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 S V++RDLK +NL+++ +G IK+ DFGL + T T Y APE+L Sbjct: 128 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED-N 186 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y AVD W LG + EM+ R F I +E+ +P Sbjct: 187 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM-----EEIRFP---------- 231 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFFQDV 289 L + +SLLS +L DP +R+ AK + H FF + Sbjct: 232 --------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 273 >4CFH-A nrPDB Length = 493 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 83/288 (28%), Positives = 129/288 (44%), Gaps = 34/288 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHP 61 ++ + +G GT+G V +++LTG VA+K + R + V REI LK HP Sbjct: 34 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 93 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +I+KL VI T + +++V E++ L ++ + + + Q+L G+ +CH Sbjct: 94 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR--LDEKESRRLFQQILSGVDYCHR 151 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 H V+HRDLKP+N+L++ K+ADFGL+ + Y APE++ G Y Sbjct: 152 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYA 210 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VDIWS G I ++ F D + LF+ G+ P Y Sbjct: 211 GPEVDIWSSGVILYALLCGTLPF-DDDHVPTLFKKI----------CDGIFYTPQY---- 255 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 L+ SLL ML DP KR + K H +F+ Sbjct: 256 --------------LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQ 289 >1PHK-A nrPDB Length = 298 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 78/302 (25%), Positives = 133/302 (44%), Gaps = 42/302 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL-------DTETEGVPSTAIREISL 54 EN++ E +G G VV + +K T + A+K I + E + + ++E+ + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 55 LKELN-HPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLL 112 L++++ HPNI++L D T +LVF+ + +L ++ + + + + LL Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYL--TEKVTLSEKETRKIMRALL 134 Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 + + H ++HRDLKP+N+L++ + IKL DFG + P T Y APE Sbjct: 135 EVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLD-PGEKLREVCGTPSYLAPE 193 Query: 173 ILL-----GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227 I+ Y VD+WS G I ++ F ++ L I Sbjct: 194 IIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSG--------- 244 Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 +Y+ P+W + + L+S+ L P KR +A+ ALAHPFFQ Sbjct: 245 -------NYQFGSPEWDDY---------SDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQ 288 Query: 288 DV 289 Sbjct: 289 QY 290 >1FOT-A nrPDB Length = 318 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 134/296 (45%), Gaps = 42/296 (14%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIREISLLKELN 59 +++FQ + +G G++G V+ R++ G A+K ++ + E +L + Sbjct: 5 LQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVT 64 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HP I+++ +++++ +++ L + S P P+ K Y ++ L + Sbjct: 65 HPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKS--QRFPNPVAKFYAAEVCLALEYL 122 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 HS +++RDLKP+N+L++ G IK+ DFG A+ VP TYT T Y APE++ K Sbjct: 123 HSKDIIYRDLKPENILLDKNGHIKITDFGFAK--YVPDVTYT-LCGTPDYIAPEVV-STK 178 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y+ ++D WS G + EM+ F + + +I Sbjct: 179 PYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAE------------------- 219 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDV 289 + P +ED + LLS+++ D ++R+ + HP+F++V Sbjct: 220 ----------LRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEV 265 >4RED-A nrPDB Length = 351 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 84/288 (29%), Positives = 129/288 (44%), Gaps = 34/288 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHP 61 ++ + +G GT+G V +++LTG VA+K + R + V REI LK HP Sbjct: 15 HYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 74 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +I+KL VI T + +++V E++ L ++ + + + Q+L G+ +CH Sbjct: 75 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR--LDEKESRRLFQQILSGVDYCHR 132 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 H V+HRDLKP+N+L++ K+ADFGL+ + Y APE++ G Y Sbjct: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYA 191 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VDIWS G I ++ F D + LF+ G+ P Y Sbjct: 192 GPEVDIWSSGVILYALLCGTLPF-DDDHVPTLFKKI----------CDGIFYTPQY---- 236 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 L+ SLL ML DP KR S K H +F+ Sbjct: 237 --------------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ 270 >4NIF-A nrPDB Length = 333 Score = 250 bits (640), Expect = 4e-67, Method: Composition-based stats. Identities = 79/306 (25%), Positives = 122/306 (39%), Gaps = 44/306 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLL-KELNH 60 + + E IG G+Y + +K T A+K I EI +L + H Sbjct: 8 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPS------EEIEILLRYGQH 61 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGI-PLPLIKSYLFQLLQGLAFCH 119 PNI+ L DV +YLV E + + +D L + + + + H Sbjct: 62 PNIITLKDVYDDGKHVYLVTELMRGG--ELLDKILRQKFFSEREASFVLHTIGKTVEYLH 119 Query: 120 SHRVLHRDLKPQNLL-INTEGA---IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 S V+HRDLKP N+L ++ G +++ DFG A+ T + APE+L Sbjct: 120 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 179 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALF---PGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 + Y DIWSLG + M+ F P D+ + L RI T W Sbjct: 180 -RQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWN---- 234 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 + E + L+S+MLH DP++R++AK L HP+ Sbjct: 235 ---------------------TVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQ-KDK 272 Query: 293 VPHLRL 298 +P +L Sbjct: 273 LPQSQL 278 >5D9K-A nrPDB Length = 330 Score = 250 bits (640), Expect = 4e-67, Method: Composition-based stats. Identities = 81/297 (27%), Positives = 132/297 (44%), Gaps = 43/297 (14%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTG----EVVALKKIRLDTETEGVPSTAIREISLLKEL 58 F+ ++ +G+G++G V+ + K++G ++ A+K ++ T E +L E+ Sbjct: 31 QFELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEV 89 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 NHP IVKL TE KLYL+ +FL F S +K YL +L L Sbjct: 90 NHPFIVKLHYAFQTEGKLYLILDFLRGG-DLFTRLSKEVMFTEEDVKFYLAELALALDHL 148 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 HS +++RDLKP+N+L++ EG IKL DFGL++ + T+ Y APE++ + Sbjct: 149 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV-NRR 207 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR-TLGTPDEVVWPGVTSMPDYK 237 ++ + D WS G + EM+T F G + + I + LG P Sbjct: 208 GHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQF------------- 254 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA-----KAALAHPFFQDV 289 L + +SLL + +P R+ A + H FF + Sbjct: 255 -----------------LSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTI 294 >4RLP-A nrPDB Length = 288 Score = 250 bits (639), Expect = 5e-67, Method: Composition-based stats. Identities = 81/299 (27%), Positives = 133/299 (44%), Gaps = 41/299 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLDTETEGVPSTA--IREISLLK 56 E F+ + +G+G YG V++ R TG++ A+K ++ TA E ++L+ Sbjct: 5 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 64 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 E+ HP IV L+ T KLYL+ E+L + FM YL ++ L Sbjct: 65 EVKHPFIVDLIYAFQTGGKLYLILEYLSGG-ELFMQLEREGIFMEDTACFYLAEISMALG 123 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 H +++RDLKP+N+++N +G +KL DFGL + T+ Y APEIL+ Sbjct: 124 HLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMR 183 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 ++ AVD WSLG + +M+T F G++ + +I + Sbjct: 184 SG-HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK----------------- 225 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFFQDVT 290 + P L ++ R LL ++L + R+ A AHPFF+ + Sbjct: 226 ------------LNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHIN 272 >2YAB-A nrPDB Length = 361 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 74/303 (24%), Positives = 130/303 (42%), Gaps = 38/303 (12%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEG----VPSTAIREISLLKELN 59 + E++G G + +V K R K TG A K I+ RE+S+L+++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HPNI+ L DV + L+ E + L F+ + + S++ Q+L G+ + Sbjct: 74 HPNIITLHDVYENRTDVVLILELVSGGELFDFL--AQKESLSEEEATSFIKQILDGVNYL 131 Query: 119 HSHRVLHRDLKPQNLLINTEG----AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 H+ ++ H DLKP+N+++ + IKL DFGLA V + + T + APEI+ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVAPEIV 190 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 + D+WS+G I +++ + F GD++ + L I DE Sbjct: 191 -NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDE---------- 239 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 + E + + ++L + KR++ + AL HP+ V Sbjct: 240 ---------------EFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDTQQA 284 Query: 295 HLR 297 +R Sbjct: 285 MVR 287 >2XIK-A nrPDB Length = 294 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 80/295 (27%), Positives = 129/295 (43%), Gaps = 32/295 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E F K+++IG+G++G VYK + T EVVA+K I L+ +EI++L + + P Sbjct: 19 ELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAE-DEIEDIQQEITVLSQCDSP 77 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 I + KL+++ E+L +D + I + L ++L+GL + HS Sbjct: 78 YITRYFGSYLKSTKLWIIMEYLGGG--SALDLLKPGPLEETYIATILREILKGLDYLHSE 135 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 R +HRD+K N+L++ +G +KLADFG+A V T ++ APE++ Y Sbjct: 136 RKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSA-YD 194 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 DIWSLG E+ +S++ + R+ + G S P Sbjct: 195 FKADIWSLGITAIELAKGEPP---NSDLHPM-RVLFLIPKNSPPTLEGQHSKP------- 243 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296 + + L+ DP R +AK L H F TK L Sbjct: 244 -----------------FKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFL 281 >2Y7J-A nrPDB Length = 365 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 77/299 (25%), Positives = 136/299 (45%), Gaps = 41/299 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTET------EGVPSTAIREISLL 55 + + + IG G VV + ++ TG A+K + + E E V RE +L Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 56 KEL-NHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQ 113 +++ HP+I+ L+D + + ++LVF+ + +L ++ + + +S + LL+ Sbjct: 154 RQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYL--TEKVALSEKETRSIMRSLLE 211 Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 173 ++F H++ ++HRDLKP+N+L++ I+L+DFG + P T Y APEI Sbjct: 212 AVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHL-EPGEKLRELCGTPGYLAPEI 270 Query: 174 L-----LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228 L Y VD+W+ G I ++ F +I L I Sbjct: 271 LKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEG---------- 320 Query: 229 GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 Y+ S P+W + + L+S++L DP R++A+ AL HPFF+ Sbjct: 321 ------QYQFSSPEWDDR---------SSTVKDLISRLLQVDPEARLTAEQALQHPFFE 364 >4D2V-A nrPDB Length = 356 Score = 250 bits (638), Expect = 6e-67, Method: Composition-based stats. Identities = 90/297 (30%), Positives = 134/297 (45%), Gaps = 35/297 (11%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ ++ E IG G + V A + LTGE+VA+K + +T +P EI LK L H Sbjct: 28 LKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPR-IKTEIEALKNLRH 86 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 +I +L V+ T NK+++V E+ +L ++ + + + Q++ +A+ H Sbjct: 87 QHICQLYHVLETANKIFMVLEYCPGGELFDYIISQ--DRLSEEETRVVFRQIVSAVAYVH 144 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGL-ARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 S HRDLKP+NLL + +KL DFGL A+ G L Y APE++ G Sbjct: 145 SQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKS 204 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y + D+WS+G + ++ F D+ + +I R K Sbjct: 205 YLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRG------------------KY 246 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-QDVTKPVP 294 PKW L LL QML DP KRIS K L HP+ QD PV Sbjct: 247 DVPKW-----------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVE 292 >3IS5-A nrPDB Length = 285 Score = 250 bits (638), Expect = 8e-67, Method: Composition-based stats. Identities = 82/293 (27%), Positives = 126/293 (43%), Gaps = 36/293 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + F K+G G +G V+ + +G +K I D ++ EI +LK L+HP Sbjct: 22 DLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKD-RSQVPMEQIEAEIEVLKSLDHP 80 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQD--LKKFMDASAL-TGIPLPLIKSYLFQLLQGLAFC 118 NI+K+ +V + +Y+V E L++ + A A + + + Q++ LA+ Sbjct: 81 NIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYF 140 Query: 119 HSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 HS V+H+DLKP+N+L IK+ DFGLA F + T+ T Y APE+ Sbjct: 141 HSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHS-TNAAGTALYMAPEVFK 199 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 + + DIWS G + ++T F G S +EV P+ Sbjct: 200 --RDVTFKCDIWSAGVVMYFLLTGCLPFTGTS--------------LEEVQQKATYKEPN 243 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 Y PL LL QML DP +R SA L H +F+ Sbjct: 244 YAVE------------CRPLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >4QMW-A nrPDB Length = 310 Score = 249 bits (637), Expect = 9e-67, Method: Composition-based stats. Identities = 78/295 (26%), Positives = 130/295 (44%), Gaps = 32/295 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E F K+EKIG+G++G V+K + T +VVA+K I L+ +EI++L + + P Sbjct: 29 ELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAE-DEIEDIQQEITVLSQCDSP 87 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 + K + KL+++ E+L +D + I + L ++L+GL + HS Sbjct: 88 YVTKYYGSYLKDTKLWIIMEYLGGG--SALDLLEPGPLDETQIATILREILKGLDYLHSE 145 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 + +HRD+K N+L++ G +KLADFG+A V T ++ APE++ Y Sbjct: 146 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSA-YD 204 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 + DIWSLG E+ SE+ + +F + G S P Sbjct: 205 SKADIWSLGITAIELARGEPP---HSELHPMKVLFLIPKNNPPTL-EGNYSKP------- 253 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296 + + L+ +P+ R +AK L H F K +L Sbjct: 254 -----------------LKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYL 291 >5J5T-A nrPDB Length = 370 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 78/290 (26%), Positives = 129/290 (44%), Gaps = 31/290 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E+F+ +++IG GTYG VYKARN TGE+ A+K I+L+ + +EI ++K+ HP Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPG--EDFAVVQQEIIMMKDCKHP 61 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NIV +KL++ EF L+ + + I + LQGL + HS Sbjct: 62 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGP--LSELQIAYVSRETLQGLYYLHS 119 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI--LLGCK 178 +HRD+K N+L+ G +KLADFG++ + + T ++ APE+ + Sbjct: 120 KGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKG 179 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y+ D+W++G E+ + + LF + ++ P P + + Sbjct: 180 GYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQP-----PKLKDKMKWSN 234 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 SF + L +P KR +A+ L HPF Sbjct: 235 SFH-------------------HFVKMALTKNPKKRPTAEKLLQHPFVTQ 265 >2W4O-A nrPDB Length = 349 Score = 248 bits (635), Expect = 1e-66, Method: Composition-based stats. Identities = 78/286 (27%), Positives = 130/286 (45%), Gaps = 34/286 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 F+ ++G G +VY+ + K T + ALK ++ + + V + EI +L L+HPNI Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRT----EIGVLLRLSHPNI 110 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 +KL ++ T ++ LV E + + F + Q+L+ +A+ H + + Sbjct: 111 IKLKEIFETPTEISLVLELVTGG-ELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGI 169 Query: 124 LHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 +HRDLKP+NLL T + +K+ADFGL++ V T Y APEIL GC Y Sbjct: 170 VHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQV-LMKTVCGTPGYCAPEILRGCA-Y 227 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VD+WS+G I ++ F + +FR +Y Sbjct: 228 GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNC---------------EYYFIS 272 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P W + + + L+ +++ DP KR++ AL HP+ Sbjct: 273 PWWD---------EVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 309 >5DBX-A nrPDB Length = 328 Score = 248 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 76/299 (25%), Positives = 126/299 (42%), Gaps = 32/299 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ E IG G VV A K E VA+K+I L+ + ++EI + + +HP Sbjct: 11 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKC-QTSMDELLKEIQAMSQCSHP 69 Query: 62 NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTG------IPLPLIKSYLFQLLQG 114 N+V +++L+LV + L + + G + +I + L ++L+G Sbjct: 70 NVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEG 129 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV-----RTYTHEVVTLWYR 169 L + H + +HRDLK N+L+ +G++++ADFG++ + V T + Sbjct: 130 LDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWM 189 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 APE++ + Y D+WS G E+ T A + + L + E Sbjct: 190 APEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVED 249 Query: 230 VTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 M Y SF R LLS L DP+KR +A L FFQ Sbjct: 250 KEMMKKYGKSF-------------------RKLLSLCLQKDPSKRPTAAELLKCKFFQK 289 >3F3Z-A nrPDB Length = 277 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 76/295 (25%), Positives = 118/295 (40%), Gaps = 34/295 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 + IG G++G V A K T A KKI +EI ++K L+HPNI Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFV--EDVDRFKQEIEIMKSLDHPNI 68 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 ++L + +YLV E + F + +L +A+CH V Sbjct: 69 IRLYETFEDNTDIYLVMELCTGG-ELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNV 127 Query: 124 LHRDLKPQNLLI---NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 HRDLKP+N L + + +KL DFGLA F P + +V T +Y +P++L G Y Sbjct: 128 AHRDLKPENFLFLTDSPDSPLKLIDFGLAARFK-PGKMMRTKVGTPYYVSPQVLEG--LY 184 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 D WS G + ++ F ++ + + +I T E W V Sbjct: 185 GPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNV---------- 234 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPH 295 SL+ ++L P +RI++ AL H +F+ P Sbjct: 235 ---------------SPQAESLIRRLLTKSPKQRITSLQALEHEWFEKQLSSSPR 274 >6HXF-B nrPDB Length = 302 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 89/293 (30%), Positives = 134/293 (45%), Gaps = 32/293 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E ++ V ++G+G +G VYKA+NK TG + A K I +T++E I EI +L +HP Sbjct: 19 EVWEIVGELGDGAFGKVYKAKNKETGALAAAKVI--ETKSEEELEDYIVEIEILATCDHP 76 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 IVKLL + + KL+++ EF + G+ P I+ Q+L+ L F HS Sbjct: 77 YIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSK 136 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL----LGC 177 R++HRDLK N+L+ EG I+LADFG++ ++ + T ++ APE++ + Sbjct: 137 RIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKD 196 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 Y DIWSLG EM + + L +I S P Sbjct: 197 TPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKI--------------AKSDPPTL 242 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 + KW + R L L +P R SA L HPF +T Sbjct: 243 LTPSKW------------SVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSIT 283 >4APC-A nrPDB Length = 350 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 75/289 (25%), Positives = 127/289 (43%), Gaps = 30/289 (10%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ME + +++KIGEG++G ++ G +K+I + + + RE+++L + H Sbjct: 23 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 82 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 PNIV+ + LY+V ++ DL K ++A I + Q+ L H Sbjct: 83 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 142 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 ++LHRD+K QN+ + +G ++L DFG+AR V + T +Y +PEI K Sbjct: 143 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICEN-KP 201 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 Y+ DIW+LGC+ E+ T + F S + + +I P + + Sbjct: 202 YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHY------------ 249 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 D RSL+SQ+ +P R S + L F Sbjct: 250 ----------------SYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAK 282 >3TXO-A nrPDB Length = 353 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 82/297 (27%), Positives = 132/297 (44%), Gaps = 39/297 (13%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTA-IREISLLKEL- 58 ++NF+ + +G+G++G V AR K TG++ A+K ++ D + + E +L Sbjct: 22 IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR 81 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 NHP + +L T ++L+ V EF++ F + Y +++ L F Sbjct: 82 NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMF-HIQKSRRFDEARARFYAAEIISALMFL 140 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 H +++RDLK N+L++ EG KLADFG+ + T T Y APEIL Sbjct: 141 HDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEM- 199 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y AVD W++G + EM+ A F ++E D I DEVV+P Sbjct: 200 LYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN-----DEVVYPTW-------- 246 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA------KAALAHPFFQDV 289 L ED +L + +P R+ + A L HPFF+++ Sbjct: 247 ----------------LHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEI 287 >6C9D-A nrPDB Length = 459 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 76/249 (30%), Positives = 117/249 (46%), Gaps = 2/249 (0%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 N++ + IG+G + V AR+ LTG VA+K I RE+ ++K LNHPN Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 81 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 IVKL +VI TE LYLV E+ + F A + ++ Q++ + +CH Sbjct: 82 IVKLFEVIETEKTLYLVMEYASGG-EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKY 140 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182 ++HRDLK +NLL++ + IK+ADFG + F V + Y APE+ G KY Sbjct: 141 IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVG-NKLDEFCGSPPYAAPELFQGKKYDGP 199 Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPK 242 VD+WSLG I +V+ F G + + R+ R + ++ Sbjct: 200 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNP 259 Query: 243 WARQDFSKV 251 R ++ Sbjct: 260 IKRGSLEQI 268 >3ZUT-A nrPDB Length = 362 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 77/287 (26%), Positives = 123/287 (42%), Gaps = 30/287 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ V+ IG G +GV R+K + E+VA+K I E + REI + L HP Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKREIINHRSLRHP 75 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+ +VI T L +V E+ + F + + QL+ G+++CH+ Sbjct: 76 NIVRFKEVILTPTHLAIVMEYASGG-ELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 Query: 122 RVLHRDLKPQNLLINTEG--AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 +V HRDLK +N L++ +K+ FG +++ V V T Y APE+LL +Y Sbjct: 135 QVCHRDLKLENTLLDGSPAPRLKICAFGYSKS-SVLHSQPKSTVGTPAYIAPEVLLKKEY 193 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 D+WS G M+ F E + + ++PDY Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI-------HRILNVQYAIPDYVH- 245 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 + + R L+S++ DP KRIS H +F Sbjct: 246 ---------------ISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >2YZA-A nrPDB Length = 276 Score = 247 bits (632), Expect = 3e-66, Method: Composition-based stats. Identities = 83/288 (28%), Positives = 127/288 (44%), Gaps = 34/288 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHP 61 ++ + +G GT+G V ++LTG VA+K + R + V REI LK HP Sbjct: 12 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 71 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +I+KL VI T ++V E++ L ++ + + Q+L + +CH Sbjct: 72 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAVDYCHR 129 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 H V+HRDLKP+N+L++ K+ADFGL+ + Y APE++ G Y Sbjct: 130 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRDSCGSPNYAAPEVISGRLYA 188 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VDIWS G I ++ F D + LF+ R GV +P+Y Sbjct: 189 GPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRG----------GVFYIPEY---- 233 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 L+ +LL ML DP KR + K H +F+ Sbjct: 234 --------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 267 >2HAK-A nrPDB Length = 328 Score = 247 bits (632), Expect = 3e-66, Method: Composition-based stats. Identities = 76/249 (30%), Positives = 117/249 (46%), Gaps = 2/249 (0%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 N++ + IG+G + V AR+ LTG VA+K I RE+ ++K LNHPN Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 75 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 IVKL +VI TE LYLV E+ + F A + ++ Q++ + +CH Sbjct: 76 IVKLFEVIETEKTLYLVMEYASGG-EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKY 134 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182 ++HRDLK +NLL++ + IK+ADFG + F V + Y APE+ G KY Sbjct: 135 IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVG-NKLDTFCGSPPYAAPELFQGKKYDGP 193 Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPK 242 VD+WSLG I +V+ F G + + R+ R + ++ Sbjct: 194 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNP 253 Query: 243 WARQDFSKV 251 R ++ Sbjct: 254 IKRGSLEQI 262 >2YCR-A nrPDB Length = 323 Score = 247 bits (631), Expect = 4e-66, Method: Composition-based stats. Identities = 80/298 (26%), Positives = 126/298 (42%), Gaps = 38/298 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTA------IREISLL 55 + + + +G G G V A + T + VA+K I G A EI +L Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 56 KELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 K+LNHP I+K+ + E+ Y+V E + + F + K Y +Q+L + Sbjct: 70 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGG-ELFDKVVGNKRLKEATCKLYFYQMLLAV 127 Query: 116 AFCHSHRVLHRDLKPQNLLIN---TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 + H + ++HRDLKP+N+L++ + IK+ DFG ++ G T T Y APE Sbjct: 128 QYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRT-LCGTPTYLAPE 186 Query: 173 IL--LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 +L +G Y+ AVD WSLG I ++ F +V Sbjct: 187 VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH---------------RTQVSLKDQ 231 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + Y WA + E L+ ++L DP R + + AL HP+ QD Sbjct: 232 ITSGKYNFIPEVWA---------EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 280 >4CSV-A nrPDB Length = 275 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 65/266 (24%), Positives = 123/266 (46%), Gaps = 20/266 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 K+G G +G VY+ + + VA+K ++ T + ++E ++K+L HPN Sbjct: 12 EITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS---VEEFLQEAQIMKKLKHPN 68 Query: 63 IVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +V+L V E +Y++ E++ H L ++ + + Q+ G+A+ S Sbjct: 69 LVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQ 128 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV---TLWYRAPEILLGCK 178 +HRDL +N L+ +K+ADFGLAR YT + + APE + Sbjct: 129 NFIHRDLAARNCLVGENNVVKVADFGLARLINED--EYTARAGAKFPIKWTAPEAI-SYN 185 Query: 179 YYSTAVDIWSLGCIFAEMVT-RRALFPGDS------EIDQLFRIFRTLGTPDEV---VWP 228 +S D+W+ G + E+ T + +PG S ++++ +R+ R G P+E+ + Sbjct: 186 RFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIYELMLQ 245 Query: 229 GVTSMPDYKPSFPKWARQDFSKVVPP 254 P+ +P+F + + +P Sbjct: 246 CWNKSPEERPTFAETLHALETMFLPE 271 >4FZF-B nrPDB Length = 283 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 77/295 (26%), Positives = 130/295 (44%), Gaps = 32/295 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E F K+E+IG+G++G V+K + T +VVA+K I L+ +EI++L + + Sbjct: 8 ELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAE-DEIEDIQQEITVLSQCDSS 66 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 + K +KL+++ E+L +D I + L ++L+GL + HS Sbjct: 67 YVTKYYGSYLKGSKLWIIMEYLGGG--SALDLLRAGPFDEFQIATMLKEILKGLDYLHSE 124 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 + +HRD+K N+L++ +G +KLA FG+A V T ++ APE++ Y Sbjct: 125 KKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA-YD 183 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 + DIWSLG E+ + LF I + + P Sbjct: 184 SKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPK---------------------NNP 222 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296 DF+K + + L+ DP+ R +AK L H F +K +L Sbjct: 223 PTLVGDFTKSF-------KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYL 270 >6FDY-U nrPDB Length = 276 Score = 247 bits (630), Expect = 6e-66, Method: Composition-based stats. Identities = 89/298 (29%), Positives = 140/298 (46%), Gaps = 38/298 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKAR-NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 ++ F E++G GTY VYKA K T EVVA+K + + + + EI +LK + Sbjct: 10 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIR 69 Query: 60 HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HP+IV+L D + +YL+ EF DL +F+ + +P + + ++ QL L F Sbjct: 70 HPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRI--LPEKVARVFMQQLASALQFL 127 Query: 119 HSHRVLHRDLKPQNLLIN--TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 H + H DLKPQN+L++ + +KLADFG A+ + + Y APE++ Sbjct: 128 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLR-GSPLYMAPEMVCQ 186 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALF--PGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 + Y VD+WS+G I E + + F SE+++ R R + P Sbjct: 187 -RQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELP------------ 233 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 + P L D R LL ++L DP++RIS + AHP+ P Sbjct: 234 ----------------LRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMP 275 >5D7A-A nrPDB Length = 308 Score = 247 bits (630), Expect = 6e-66, Method: Composition-based stats. Identities = 76/297 (25%), Positives = 127/297 (42%), Gaps = 42/297 (14%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NHPN 62 F+ VE +G GTYG VYK R+ TG++ A+K + + + E +EI++LK+ +H N Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE---EEIKQEINMLKKYSHHRN 75 Query: 63 IVKLLDVIHTENK------LYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 I +N L+LV EF + + + + I ++L+GL Sbjct: 76 IATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGL 135 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL- 174 + H H+V+HRD+K QN+L+ +KL DFG++ V + T ++ APE++ Sbjct: 136 SHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 195 Query: 175 ---LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT 231 Y D+WSLG EM + LF I R Sbjct: 196 CDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPA----------- 244 Query: 232 SMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 P+ + +SK +S + L + ++R + + + HPF +D Sbjct: 245 ---------PRLKSKKWSKKF-------QSFIESCLVKNHSQRPATEQLMKHPFIRD 285 >3UTO-A nrPDB Length = 573 Score = 246 bits (629), Expect = 8e-66, Method: Composition-based stats. Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 31/294 (10%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++++ E++G G +GVV++ + TG A K + E T +EI + L H Sbjct: 156 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTP--HESDKETVRKEIQTMSVLRH 213 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 P +V L D +N++ +++EF+ A + Y+ Q+ +GL H Sbjct: 214 PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE 273 Query: 121 HRVLHRDLKPQNLLINTE--GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 + +H DLKP+N++ T+ +KL DFGL P ++ T + APE+ G K Sbjct: 274 NNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLD-PKQSVKVTTGTAEFAAPEVAEG-K 331 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 D+WS+G + +++ + F G+++ + L + D+ + G+ Sbjct: 332 PVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGI-------- 383 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 EDG+ + ++L DPN R++ AL HP+ P Sbjct: 384 -----------------SEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAP 420 >5F9E-A nrPDB Length = 353 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 75/293 (25%), Positives = 134/293 (45%), Gaps = 34/293 (11%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKEL- 58 +E+F+ + +G+G++G V+ A K T + A+K ++ D + + E +L Sbjct: 18 IEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAW 77 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HP + + T+ L+ V E+L+ + + L Y +++ GL F Sbjct: 78 EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMY-HIQSCHKFDLSRATFYAAEIILGLQFL 136 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 HS +++RDLK N+L++ +G IK+ADFG+ + + T Y APEILLG K Sbjct: 137 HSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQK 196 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y+ +VD WS G + EM+ ++ F G E + I P Sbjct: 197 -YNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI------------------RMDNP 237 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAK-AALAHPFFQDVT 290 +P+W L+++ + LL ++ +P KR+ + HP F+++ Sbjct: 238 FYPRW-----------LEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREIN 279 >3UDB-A nrPDB Length = 317 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 79/287 (27%), Positives = 123/287 (42%), Gaps = 30/287 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ V+ IG G +GV R+K E+VA+K I E + REI + L HP Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYI---ERGEKIDENVKREIINHRSLRHP 75 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+ +VI T L +V E+ + F + + QL+ G+++ H+ Sbjct: 76 NIVRFKEVILTPTHLAIVMEYASGG-ELFERICNAGRFSEDEARFFFQQLISGVSYAHAM 134 Query: 122 RVLHRDLKPQNLLINTEG--AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 +V HRDLK +N L++ +K+ADFG ++A V V T Y APE+LL +Y Sbjct: 135 QVAHRDLKLENTLLDGSPAPRLKIADFGYSKA-SVLHSQPKSAVGTPAYIAPEVLLKKEY 193 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 D+WS G M+ F E + + ++PDY Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTI-------HRILNVQYAIPDYVH- 245 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 + + R L+S++ DP KRIS H +F Sbjct: 246 ---------------ISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >2Z7Q-A nrPDB Length = 321 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 41/296 (13%) Query: 3 NFQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 +F+ ++ +G+G++G V+ R +G + A+K ++ T E +L ++N Sbjct: 29 HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVN 88 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 HP +VKL TE KLYL+ +FL F S +K YL +L GL H Sbjct: 89 HPFVVKLHYAFQTEGKLYLILDFLRGG-DLFTRLSKEVMFTEEDVKFYLAELALGLDHLH 147 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 S +++RDLKP+N+L++ EG IKL DFGL++ + T+ Y APE++ + Sbjct: 148 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVV-NRQG 206 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR-TLGTPDEVVWPGVTSMPDYKP 238 +S + D WS G + EM+T F G + + I + LG P Sbjct: 207 HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQF-------------- 252 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDV 289 L + +SLL + +P R+ A+ H F+ + Sbjct: 253 ----------------LSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTI 292 >2A27-A nrPDB Length = 321 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 72/303 (23%), Positives = 129/303 (42%), Gaps = 38/303 (12%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP----STAIREISLLKELN 59 + E++G G + +V K R K TG A K I+ RE+S+L+++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 H N++ L DV + L+ E + L F+ + + S++ Q+L G+ + Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFL--AQKESLSEEEATSFIKQILDGVNYL 131 Query: 119 HSHRVLHRDLKPQNLLINTEG----AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 H+ ++ H DLKP+N+++ + IKL DFGLA V + + T + APEI+ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVAPEIV 190 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 + D+WS+G I +++ + F GD++ + L I DE Sbjct: 191 -NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDE---------- 239 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 + E + + ++L + KR++ + AL HP+ V Sbjct: 240 ---------------EFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQA 284 Query: 295 HLR 297 +R Sbjct: 285 MVR 287 >3GUB-A nrPDB Length = 295 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 131/296 (44%), Gaps = 38/296 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP----STAIREISLLKE 57 + + E++G G + VV K R K TG A K I+ RE+S+LKE Sbjct: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70 Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 + HPN++ L +V + + L+ E + +L F+ + + +L Q+L G+ Sbjct: 71 IQHPNVITLHEVYENKTDVILIGELVAGGELFDFL--AEKESLTEEEATEFLKQILNGVY 128 Query: 117 FCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 + HS ++ H DLKP+N+++ IK+ DFGLA + + T + APE Sbjct: 129 YLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFG-NEFKNIFGTPEFVAPE 187 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 I+ + D+WS+G I +++ + F GD++ + L + ++ + ++ Sbjct: 188 IV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSA 246 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + + + ++L DP KR++ + +L HP+ + Sbjct: 247 L-------------------------AKDFIRRLLVKDPKKRMTIQDSLQHPWIKP 277 >5YV8-A nrPDB Length = 298 Score = 245 bits (625), Expect = 2e-65, Method: Composition-based stats. Identities = 80/314 (25%), Positives = 138/314 (43%), Gaps = 57/314 (18%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--------------------- 39 + + ++IG+G+YGVV A N+ A+K + Sbjct: 12 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 71 Query: 40 ---ETEGVPSTAIREISLLKELNHPNIVKLLDVIHT--ENKLYLVFEFLHQDLKKFMDAS 94 + G +EI++LK+L+HPN+VKL++V+ E+ LY+VFE ++Q M+ Sbjct: 72 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 129 Query: 95 ALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV 154 L + + Y L++G+ + H +++HRD+KP NLL+ +G IK+ADFG++ F Sbjct: 130 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKG 189 Query: 155 PVRTYTHEVVTLWYRAPEILLGCKYY--STAVDIWSLGCIFAEMVTRRALFPGDSEIDQL 212 ++ V T + APE L + A+D+W++G V + F Sbjct: 190 SDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF--------- 240 Query: 213 FRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPN 272 DE + + + FP P + ED + L+++ML +P Sbjct: 241 ---------MDERIMCLHSKIKSQALEFPDQ---------PDIAEDLKDLITRMLDKNPE 282 Query: 273 KRISAKAALAHPFF 286 RI HP+ Sbjct: 283 SRIVVPEIKLHPWV 296 >1ZWS-A nrPDB Length = 288 Score = 245 bits (625), Expect = 2e-65, Method: Composition-based stats. Identities = 72/303 (23%), Positives = 129/303 (42%), Gaps = 38/303 (12%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP----STAIREISLLKELN 59 + E++G G + +V K R K TG A K I+ RE+S+L+++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 H N++ L DV + L+ E + L F+ + + S++ Q+L G+ + Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFL--AQKESLSEEEATSFIKQILDGVNYL 131 Query: 119 HSHRVLHRDLKPQNLLINTEG----AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 H+ ++ H DLKP+N+++ + IKL DFGLA V + + T + APEI+ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVAPEIV 190 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 + D+WS+G I +++ + F GD++ + L I DE Sbjct: 191 -NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDE---------- 239 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 + E + + ++L + KR++ + AL HP+ V Sbjct: 240 ---------------EFFSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQA 284 Query: 295 HLR 297 +R Sbjct: 285 MVR 287 >3UC3-A nrPDB Length = 361 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 76/287 (26%), Positives = 121/287 (42%), Gaps = 30/287 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + + V+ IG G +GV R+KLT E+VA+K I + REI + L HP Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGAAIDENVQREIINHRSLRHP 76 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NIV+ +VI T L ++ E+ + + + + QLL G+++CHS Sbjct: 77 NIVRFKEVILTPTHLAIIMEYASGG-ELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 Query: 122 RVLHRDLKPQNLLINTEG--AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 ++ HRDLK +N L++ +K+ DFG +++ V V T Y APE+LL +Y Sbjct: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPEVLLRQEY 194 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 D+WS G M+ F E + + + S+PD Sbjct: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI-------LSVKYSIPDDI-- 245 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 + + L+S++ DP RIS H +F Sbjct: 246 --------------RISPECCHLISRIFVADPATRISIPEIKTHSWF 278 >1KOA-A nrPDB Length = 491 Score = 244 bits (623), Expect = 3e-65, Method: Composition-based stats. Identities = 71/294 (24%), Positives = 129/294 (43%), Gaps = 31/294 (10%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++++ E++G G +GVV++ + TG A K + E T +EI + L H Sbjct: 50 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTP--HESDKETVRKEIQTMSVLRH 107 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 P +V L D +N++ +++EF+ A + Y+ Q+ +GL H Sbjct: 108 PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE 167 Query: 121 HRVLHRDLKPQNLLINTE--GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 + +H DLKP+N++ T+ +KL DFGL P ++ T + APE+ G K Sbjct: 168 NNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLD-PKQSVKVTTGTAEFAAPEVAEG-K 225 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 D+WS+G + +++ + F G+++ + L + D+ + G+ Sbjct: 226 PVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGI-------- 277 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 EDG+ + ++L DPN R++ AL HP+ P Sbjct: 278 -----------------SEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAP 314 >3I6U-A nrPDB Length = 419 Score = 243 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 79/298 (26%), Positives = 126/298 (42%), Gaps = 38/298 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTA------IREISLL 55 + + + +G G G V A + T + VA++ I G A EI +L Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 56 KELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 K+LNHP I+K+ + E+ Y+V E + + F + K Y +Q+L + Sbjct: 195 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGG-ELFDKVVGNKRLKEATCKLYFYQMLLAV 252 Query: 116 AFCHSHRVLHRDLKPQNLLIN---TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 + H + ++HRDLKP+N+L++ + IK+ DFG ++ G T T Y APE Sbjct: 253 QYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRT-LCGTPTYLAPE 311 Query: 173 IL--LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 +L +G Y+ AVD WSLG I ++ F +V Sbjct: 312 VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH---------------RTQVSLKDQ 356 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + Y WA + E L+ ++L DP R + + AL HP+ QD Sbjct: 357 ITSGKYNFIPEVWA---------EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 >5JZN-A nrPDB Length = 280 Score = 243 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 82/292 (28%), Positives = 130/292 (44%), Gaps = 35/292 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E ++ IG+G + VV + + T ALK I+ ++ G E+S+L+ + HP Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKK-SKCRGKEHMIQNEVSILRRVKHP 77 Query: 62 NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NIV L++ + +LYLV E + DL + ++ L+ L + + HS Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKGGDLFDAI--TSTNKYTERDASGMLYNLASAIKYLHS 135 Query: 121 HRVLHRDLKPQNLLI----NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 ++HRD+KP+NLL+ + ++KL DFGLA P+ T T Y APEI+ Sbjct: 136 LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTV---CGTPTYVAPEIIAE 192 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 Y VDIW+ G I ++ F G G EV++ + Sbjct: 193 TG-YGLKVDIWAAGVITYILLCGFPPFRGS-------------GDDQEVLFDQILMGQVD 238 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 PS P W + + + L++ ML D ++R SA L HP+ D Sbjct: 239 FPS-PYWDN---------VSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 280 >4JG6-A nrPDB Length = 355 Score = 243 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 80/306 (26%), Positives = 128/306 (41%), Gaps = 44/306 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLL-KELNH 60 + ++ E IG G+Y V + +K T A+K I + EI +L + H Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKII------DKSKRDPTEEIEILLRYGQH 88 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGI-PLPLIKSYLFQLLQGLAFCH 119 PNI+ L DV +Y+V E + + +D + LF + + + + H Sbjct: 89 PNIITLKDVYDDGKYVYVVTELMKGG--ELLDKILRQKFFSEREASAVLFTITKTVEYLH 146 Query: 120 SHRVLHRDLKPQNLL-INTEGA---IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 + V+HRDLKP N+L ++ G I++ DFG A+ T + APE+L Sbjct: 147 AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL- 205 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALF---PGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 + Y A DIWSLG + M+T F P D+ + L RI + W V Sbjct: 206 ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSV-- 263 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 + + L+S+MLH DP++R++A L HP+ Sbjct: 264 -----------------------SDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHW-DQ 299 Query: 293 VPHLRL 298 +P +L Sbjct: 300 LPQYQL 305 >6E9W-A nrPDB Length = 443 Score = 243 bits (621), Expect = 7e-65, Method: Composition-based stats. Identities = 69/295 (23%), Positives = 120/295 (40%), Gaps = 36/295 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNH 60 E+++ V+ IG G +G V R+K T +V A+K + + + + E ++ N Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 161 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 P +V+L + LY+V E++ ++ + +P + Y +++ L HS Sbjct: 162 PWVVQLFYAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWARFYTAEVVLALDAIHS 219 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT-HEVVTLWYRAPEILL---G 176 +HRD+KP N+L++ G +KLADFG V T Y +PE+L G Sbjct: 220 MGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGG 279 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 YY D WS+G EM+ F DS + +I + PD Sbjct: 280 DGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMN---------HKNSLTFPDD 330 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI---SAKAALAHPFFQD 288 + ++ ++L+ L D R+ + H FF++ Sbjct: 331 N----------------DISKEAKNLICAFLT-DREVRLGRNGVEEIKRHLFFKN 368 >6ED6-A nrPDB Length = 415 Score = 243 bits (620), Expect = 9e-65, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 123/295 (41%), Gaps = 36/295 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNH 60 E++ V+ IG G +G V R+K + +V A+K + + + + E ++ N Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 147 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 P +V+L + LY+V E++ ++ + +P K Y +++ L HS Sbjct: 148 PWVVQLFYAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWAKFYTAEVVLALDAIHS 205 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT-HEVVTLWYRAPEILL---G 176 ++HRD+KP N+L++ G +KLADFG + V T Y +PE+L G Sbjct: 206 MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGG 265 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 +Y D WS+G EM+ F DS + +I + Sbjct: 266 DGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNS--------------- 310 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI---SAKAALAHPFFQD 288 FP+ A + + ++L+ L D R+ + HPFF++ Sbjct: 311 -LCFPEDA---------EISKHAKNLICAFLT-DREVRLGRNGVEEIRQHPFFKN 354 >3DB8-A nrPDB Length = 317 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 73/296 (24%), Positives = 125/296 (42%), Gaps = 34/296 (11%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELN 59 M+ + + +G+G + Y+ + T EV A K + + + EI++ K L+ Sbjct: 41 MKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLD 100 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 +P++V ++ +Y+V E + L + + P + ++ Q +QG+ + Sbjct: 101 NPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKA--VTEPEARYFMRQTIQGVQYL 158 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 H++RV+HRDLK NL +N + +K+ DFGLA T Y APE+L K Sbjct: 159 HNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCK-K 217 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 +S VDIWSLGCI ++ + F + RI Sbjct: 218 GHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRI----------------------- 254 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 +++ V ++ +L+ +MLH DP R S L FF P+ Sbjct: 255 ------KKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPMR 304 >3HDN-A nrPDB Length = 373 Score = 242 bits (618), Expect = 1e-64, Method: Composition-based stats. Identities = 74/294 (25%), Positives = 123/294 (41%), Gaps = 37/294 (12%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREIS-LLKELNH 60 +F ++ IG+G++G V AR+K A+K + + + + E + LLK + H Sbjct: 39 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 98 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 P +V L T +KLY V ++++ + F P + Y ++ L + HS Sbjct: 99 PFLVGLHFSFQTADKLYFVLDYINGG-ELFYHLQRERCFLEPRARFYAAEIASALGYLHS 157 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 +++RDLKP+N+L++++G I L DFGL + T + T Y APE+L + Y Sbjct: 158 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHK-QPY 216 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VD W LG + EM+ F + + I Sbjct: 217 DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKP--------------------- 255 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAK----AALAHPFFQDVT 290 ++ P + R LL +L D KR+ AK +H FF + Sbjct: 256 --------LQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLIN 301 >2X4F-A nrPDB Length = 373 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 75/284 (26%), Positives = 130/284 (45%), Gaps = 33/284 (11%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 E +G G +G V+K TG +A K I+ + EIS++ +L+H N+++L Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKD--KEEVKNEISVMNQLDHANLIQLY 152 Query: 68 DVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 D ++N + LV E++ L + + L I ++ Q+ +G+ H +LH Sbjct: 153 DAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTIL-FMKQICEGIRHMHQMYILHL 211 Query: 127 DLKPQNLLINTE--GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAV 184 DLKP+N+L IK+ DFGLAR + P T + APE++ + S Sbjct: 212 DLKPENILCVNRDAKQIKIIDFGLARRYK-PREKLKVNFGTPEFLAPEVV-NYDFVSFPT 269 Query: 185 DIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWA 244 D+WS+G I +++ + F GD++ + L I +W Sbjct: 270 DMWSVGVIAYMLLSGLSPFLGDNDAETLNNILAC-----------------------RWD 306 Query: 245 RQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 +D + + E+ + +S++L + + RISA AL HP+ D Sbjct: 307 LED--EEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSD 348 >1VZO-A nrPDB Length = 355 Score = 240 bits (612), Expect = 8e-64, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 134/303 (44%), Gaps = 39/303 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLDTETEGVP--STAIREISLL 55 +ENF+ ++ +G G YG V+ R TG++ A+K ++ T + E +L Sbjct: 53 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 112 Query: 56 KELN-HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 + + P +V L TE KL+L+ ++++ + F S ++ Y+ +++ Sbjct: 113 EHIRQSPFLVTLHYAFQTETKLHLILDYINGG-ELFTHLSQRERFTEHEVQIYVGEIVLA 171 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT-HEVVTLWYRAPEI 173 L H +++RD+K +N+L+++ G + L DFGL++ F T+ Y AP+I Sbjct: 172 LEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDI 231 Query: 174 LLGC-KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 + G + AVD WSLG + E++T + F D E + I R + + S Sbjct: 232 VRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRI----------LKS 281 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFFQ 287 P Y + + L+ ++L DP KR+ A H FFQ Sbjct: 282 EPPYPQE---------------MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQ 326 Query: 288 DVT 290 + Sbjct: 327 KIN 329 >3TKU-A nrPDB Length = 433 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 120/299 (40%), Gaps = 36/299 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIRE-ISLLKELNH 60 E+F+ ++ IG G +G V + K T + A+K + + + RE +L + Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 61 PNIVKLLDVIHTENKLYLVFEF-LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 I L EN LYLV ++ + DL + + +P + + Y+ +++ + H Sbjct: 150 QWITALHYAFQDENHLYLVMDYYVGGDLLTLL-SKFEDKLPEDMARFYIGEMVLAIDSIH 208 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTH-EVVTLWYRAPEILL--- 175 +HRD+KP N+L++ G I+LADFG + V T Y +PEIL Sbjct: 209 QLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAME 268 Query: 176 -GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 G Y D WSLG EM+ F +S ++ +I Sbjct: 269 DGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN----------------- 311 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI---SAKAALAHPFFQDVT 290 R F V + E+ + L+ +++ +R+ + H FF+ + Sbjct: 312 -------HEERFQFPSHVTDVSEEAKDLIQRLIC-SRERRLGQNGIEDFKKHAFFEGLN 362 >2HW6-A nrPDB Length = 307 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 70/302 (23%), Positives = 120/302 (39%), Gaps = 29/302 (9%) Query: 2 ENFQKV-EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59 + ++ E +GEG Y V A + G+ A+K I + + S RE+ L + Sbjct: 12 DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQCQG 69 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 + NI++L++ + + YLVFE L + + L F H Sbjct: 70 NKNILELIEFFEDDTRFYLVFEKLQGG-SILAHIQKQKHFNEREASRVVRDVAAALDFLH 128 Query: 120 SHRVLHRDLKPQNLLINTEGA---IKLADFGLARAFG-------VPVRTYTHEVVTLWYR 169 + + HRDLKP+N+L + +K+ DF L + T + Y Sbjct: 129 TKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM 188 Query: 170 APEILL----GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEV 225 APE++ +Y D+WSLG + M++ F G D + Sbjct: 189 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNK 248 Query: 226 VWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 ++ S+ + K FP K + + + L+S++L D +R+SA L HP+ Sbjct: 249 LFE---SIQEGKYEFPD-------KDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPW 298 Query: 286 FQ 287 Q Sbjct: 299 VQ 300 >5X8I-B nrPDB Length = 346 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 89/332 (26%), Positives = 141/332 (42%), Gaps = 48/332 (14%) Query: 3 NFQKVEKIGEGTYGVVYKAR-NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-- 59 ++ V+ +GEG +G V + +K G VA+K ++ + A EI +L+ LN Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK---NVDRYCEAARSEIQVLEHLNTT 70 Query: 60 HPN----IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 PN V++L+ + +VFE L F+ + L I+ +Q+ + + Sbjct: 71 DPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSV 130 Query: 116 AFCHSHRVLHRDLKPQNLLINT-------------------EGAIKLADFGLARAFGVPV 156 F HS+++ H DLKP+N+L IK+ DFG A Sbjct: 131 NFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA---TYDD 187 Query: 157 RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF 216 ++ V T YRAPE++L +S D+WS+GCI E +FP + L + Sbjct: 188 EHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMME 246 Query: 217 RTLGTPDEVVWPGVTSMPDYKPSFPKW-----ARQDFSKVVPPLDEDGR----------S 261 R LG + + + W A + S+ PL E Sbjct: 247 RILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFD 306 Query: 262 LLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293 L+ +ML YDP KRI+ + AL HPFF + K + Sbjct: 307 LIQKMLEYDPAKRITLREALKHPFFDLLKKSI 338 >4B6L-A nrPDB Length = 281 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 72/290 (24%), Positives = 112/290 (38%), Gaps = 32/290 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIREISLLKELNHPN 62 + K +G+G + Y+A + TG A+K I + + EI L ++L H + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 IV+ + +Y+ E + + + T + P ++ YL Q+L GL + H Sbjct: 71 IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLL-EPEVRYYLRQILSGLKYLHQRG 129 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182 +LHRDLK N I +K+ DFGLA P + T Y APE+LL + + Sbjct: 130 ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGP 188 Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPK 242 D+WSLGC+ ++ F + I + T Sbjct: 189 EADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYT--------------------- 227 Query: 243 WARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 + L R LL+ +L P R S L H FF P Sbjct: 228 --------LPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTP 269 >4B8L-A nrPDB Length = 286 Score = 237 bits (606), Expect = 3e-63, Method: Composition-based stats. Identities = 80/295 (27%), Positives = 133/295 (45%), Gaps = 36/295 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59 +++F +G+G +G VY AR K ++ALK + + E EGV REI + L Sbjct: 14 IDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLR 73 Query: 60 HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HPNI+++ + H ++YL+ EF +L K + +++ +L L +C Sbjct: 74 HPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGR--FDEQRSATFMEELADALHYC 131 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 H +V+HRD+KP+NLL+ +G +K+ADFG + P TL Y PE++ G K Sbjct: 132 HERKVIHRDIKPENLLMGYKGELKIADFGWS--VHAPSLRRRTMCGTLDYLPPEMIEG-K 188 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 + VD+W G + E + F S + RI Sbjct: 189 THDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVD------------------- 229 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293 K P L + + L+S++L Y P +R+ K + HP+ + ++ V Sbjct: 230 ----------LKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKANSRRV 274 >1KOB-A nrPDB Length = 387 Score = 237 bits (606), Expect = 3e-63, Method: Composition-based stats. Identities = 71/302 (23%), Positives = 134/302 (44%), Gaps = 35/302 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + + +E++G G +GVV++ K TG V K I + T EIS++ +L+HP Sbjct: 51 DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKY--TVKNEISIMNQLHHP 108 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 ++ L D + ++ L+ EFL A+ + + +Y+ Q +GL H H Sbjct: 109 KLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEH 168 Query: 122 RVLHRDLKPQNLLINTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 ++H D+KP+N++ T+ A +K+ DFGLA P T + APEI+ + Sbjct: 169 SIVHLDIKPENIMCETKKASSVKIIDFGLATKLN-PDEIVKVTTATAEFAAPEIV-DREP 226 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 D+W++G + +++ + F G+ +++ L + R DE Sbjct: 227 VGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDE--------------- 271 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ----DVTKPVPH 295 + + + + +L +P KR++ AL HP+ + ++T +P Sbjct: 272 ----------DAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDHSNLTSRIPS 321 Query: 296 LR 297 R Sbjct: 322 SR 323 >3HKO-A nrPDB Length = 345 Score = 237 bits (606), Expect = 3e-63, Method: Composition-based stats. Identities = 82/344 (23%), Positives = 133/344 (38%), Gaps = 74/344 (21%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKEL 58 + + IG+G+YGVV A T + A+K + + + P R E+ L+K+L Sbjct: 26 KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL 85 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQD-----LKKFMDASALTG--------------- 98 +HPNI +L +V E + LV E H L F+D S Sbjct: 86 HHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPEC 145 Query: 99 -------------------IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEG 139 LI + + Q+ L + H+ + HRD+KP+N L +T Sbjct: 146 NEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNK 205 Query: 140 --AIKLADFGLARAFGV----PVRTYTHEVVTLWYRAPEILLGC-KYYSTAVDIWSLGCI 192 IKL DFGL++ F T + T ++ APE+L + Y D WS G + Sbjct: 206 SFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVL 265 Query: 193 FAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVV 252 ++ FPG ++ D + ++ P+Y Sbjct: 266 LHLLLMGAVPFPGVNDADTISQVLNKKLC---------FENPNYN--------------- 301 Query: 253 PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296 L R LLS +L+ + ++R A AL HP+ + + + Sbjct: 302 -VLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSDKIYKM 344 >4RA4-A nrPDB Length = 355 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 73/296 (24%), Positives = 134/296 (45%), Gaps = 38/296 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKELN 59 + +F + +G+G++G V A K T E+ A+K ++ D + + E +L L+ Sbjct: 19 LTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD 78 Query: 60 HP-NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 P + +L T ++LY V E+++ + + P Y ++ GL F Sbjct: 79 KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMY-HIQQVGKFKEPQAVFYAAEISIGLFFL 137 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 H +++RDLK N+++++EG IK+ADFG+ + + T T Y APEI+ + Sbjct: 138 HKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEII-AYQ 196 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y +VD W+ G + EM+ + F G+ E D+LF+ S+ ++ Sbjct: 197 PYGKSVDWWAYGVLLYEMLAGQPPFDGEDE-DELFQ-----------------SIMEHNV 238 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA-----KAALAHPFFQDV 289 S+PK L ++ S+ ++ P KR+ + H FF+ + Sbjct: 239 SYPK-----------SLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI 283 >4CRL-A nrPDB Length = 406 Score = 236 bits (603), Expect = 9e-63, Method: Composition-based stats. Identities = 116/322 (36%), Positives = 176/322 (54%), Gaps = 42/322 (13%) Query: 9 KIGEGTYGVVYKARNKLTGEV--VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 K+G GTYG VYKA+ K + ALK+I E G+ +A REI+LL+EL HPN++ L Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 84 Query: 67 LDVI--HTENKLYLVFEFLHQDLKKFMDASALTG-------IPLPLIKSYLFQLLQGLAF 117 V H + K++L+F++ DL + + +P ++KS L+Q+L G+ + Sbjct: 85 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 144 Query: 118 CHSHRVLHRDLKPQNLLIN----TEGAIKLADFGLARAFGVPVR---TYTHEVVTLWYRA 170 H++ VLHRDLKP N+L+ G +K+AD G AR F P++ VVT WYRA Sbjct: 145 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 204 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEI---------DQLFRIFRTLGT 221 PE+LLG ++Y+ A+DIW++GCIFAE++T +F E DQL RIF +G Sbjct: 205 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 264 Query: 222 PDEVVWPGVTSMPDYKPSFPKWARQDFS---------KVVPPLDEDGRSLLSQMLHYDPN 272 P + W + MP++ + R ++ K D LL ++L DP Sbjct: 265 PADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPI 324 Query: 273 KRISAKAALAHPFFQDVTKPVP 294 KRI+++ A+ P+F + P+P Sbjct: 325 KRITSEQAMQDPYF--LEDPLP 344 >4AW2-A nrPDB Length = 437 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 120/298 (40%), Gaps = 36/298 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIRE-ISLLKELNH 60 E+F+ ++ IG G +G V + K +V A+K + + + RE +L + Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDS 133 Query: 61 PNIVKLLDVIHTENKLYLVFEF-LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 I L +N LYLV ++ + DL + + +P + + YL +++ + H Sbjct: 134 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLL-SKFEDRLPEEMARFYLAEMVIAIDSVH 192 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLA-RAFGVPVRTYTHEVVTLWYRAPEILL--- 175 +HRD+KP N+L++ G I+LADFG + + V T Y +PEIL Sbjct: 193 QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAME 252 Query: 176 -GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 G Y D WSLG EM+ F +S ++ +I Sbjct: 253 GGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN----------------- 295 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI---SAKAALAHPFFQDV 289 R F V + E+ + L+ +++ R+ + HPFF + Sbjct: 296 -------HKERFQFPTQVTDVSENAKDLIRRLIC-SREHRLGQNGIEDFKKHPFFSGI 345 >5LOH-A nrPDB Length = 341 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 79/297 (26%), Positives = 124/297 (41%), Gaps = 39/297 (13%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL-DTETEGVPSTAIREISLLKELN 59 +E F V+ I G +G VY + G++ A+K ++ D + + E L Sbjct: 35 IEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSK 92 Query: 60 HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 P IV L + + N +YLV E+L D+K + + Y+ ++ L + Sbjct: 93 SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGY--FDEEMAVKYISEVALALDYL 150 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF------GVPVRTYTHEVVTLWYRAPE 172 H H ++HRDLKP N+LI+ EG IKL DFGL++ + + T T Y APE Sbjct: 151 HRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPE 210 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 +LLG + + AVD W+LG E +T F ++ I + Sbjct: 211 LLLG-RAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILK--------------- 254 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 + + L ++ +S + +L D KR K HP F DV Sbjct: 255 -----------RDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDV 300 >2WQN-A nrPDB Length = 310 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 87/279 (31%), Positives = 128/279 (45%), Gaps = 30/279 (10%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL-DTETEGVPSTAIREISLLKELN 59 + NF+ +KIG G + VY+A L G VALKK+++ D + I+EI LLK+LN Sbjct: 31 LANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLN 90 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMD--ASALTGIPLPLIKSYLFQLLQGLA 116 HPN++K +N+L +V E DL + + IP + Y QL L Sbjct: 91 HPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALE 150 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 HS RV+HRD+KP N+ I G +KL D GL R F V T +Y +PE + Sbjct: 151 HMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHE 210 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 Y+ DIWSLGC+ EM ++ F GD ++ ++ +P + S Sbjct: 211 NG-YNFKSDIWSLGCLLYEMAALQSPFYGDK-----MNLYSLCKKIEQCDYPPLPS---- 260 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI 275 E+ R L++ ++ DP KR Sbjct: 261 ----------------DHYSEELRQLVNMCINPDPEKRP 283 >4I6B-A nrPDB Length = 308 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 65/293 (22%), Positives = 116/293 (39%), Gaps = 34/293 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELNH 60 + + + + +G+G + Y+ + +V A K I ++ I +EI L + L+H Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHH 87 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 ++V+ + +Y++ E+ + + + A + + P ++ YL Q++ GL + H Sbjct: 88 KHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKV--LTEPEVRYYLRQIVSGLKYLH 145 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 +LHRDLK N IN +K+ DFGLA T Y +PE+L + Sbjct: 146 EQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQG 204 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 + DIW+LGC+ M+ R F + + I T + Sbjct: 205 HGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAP---------- 254 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 + L++ ML +P R S + H FF P Sbjct: 255 -------------------AKHLIASMLSKNPEDRPSLDDIIRHDFFTQGFTP 288 >3NYO-A nrPDB Length = 576 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 78/294 (26%), Positives = 134/294 (45%), Gaps = 34/294 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGV-PSTAIREISLLKELNHPN 62 F++ +G+G +G V + + TG++ A KK+ + + A+ E +L+++N Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 Query: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +V L T++ L LV ++ DLK + G P Y ++ GL H Sbjct: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 R+++RDLKP+N+L++ G I+++D GLA +T V T+ Y APE++ + Y+ Sbjct: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVVKNER-YT 363 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 + D W+LGC+ EM+ ++ F R E V V +P+ Sbjct: 364 FSPDWWALGCLLYEMIAGQSPFQ-----------QRKKKIKREEVERLVKEVPE------ 406 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDVT 290 + RSL SQ+L DP +R+ SA+ HP F+ + Sbjct: 407 --------EYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 >3KN6-A nrPDB Length = 325 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 77/288 (26%), Positives = 124/288 (43%), Gaps = 29/288 (10%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NHPNIVKL 66 + +GEG++ + K +K + + A+K I ++ + + +EI+ LK HPNIVKL Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKII-----SKRMEANTQKEITALKLCEGHPNIVKL 71 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 +V H + +LV E L+ + F + +L+ ++ H V+HR Sbjct: 72 HEVFHDQLHTFLVMELLNGG-ELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 130 Query: 127 DLKPQNLLI---NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183 DLKP+NLL N IK+ DFG AR + TL Y APE LL Y + Sbjct: 131 DLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LLNQNGYDES 189 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW 243 D+WSLG I M++ + F R+L V D+ W Sbjct: 190 CDLWSLGVILYTMLSGQVPFQSHD---------RSLTCTSAVEIMKKIKKGDFSFEGEAW 240 Query: 244 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 + ++ + L+ +L DPNKR+ + + QD ++ Sbjct: 241 KN---------VSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQ 279 >3ORZ-A nrPDB Length = 316 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 74/299 (24%), Positives = 124/299 (41%), Gaps = 42/299 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNH 60 E+F+ + +GEG++ V AR T A+K + + E RE ++ L+H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 P VKL + KLY + + +L K++ + Y +++ L + H Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIG--SFDETCTRFYTAEIVSALEYLH 154 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT--YTHEVVTLWYRAPEILLGC 177 ++HRDLKP+N+L+N + I++ DFG A+ + V T Y +PE+L Sbjct: 155 GKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE- 213 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 K + D+W+LGCI ++V F +E +I + E +P Sbjct: 214 KSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFP--------- 264 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKA------ALAHPFFQDVT 290 R L+ ++L D KR+ + AHPFF+ VT Sbjct: 265 --------------------KARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVT 303 >4YNZ-A nrPDB Length = 342 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 78/283 (27%), Positives = 131/283 (46%), Gaps = 33/283 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 ++ + +G+G G+V + +T + VA+K + + +E V REI++LK + HP++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 64 VKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 +KL DV + LYLV E + L ++ + + + Q++ L FCHSH Sbjct: 72 LKLHDVYENKKYLYLVLEHVSGGELFDYL--VKKGRLTPKEARKFFRQIISALDFCHSHS 129 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182 + HRDLKP+NLL++ I++ADFG+A + V + Y PE++ G KY Sbjct: 130 ICHRDLKPENLLLDERNNIRIADFGMA-SLQVGDSLLETSCGSPHYACPEVIRGEKYDGR 188 Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPK 242 D+WS G I ++ F D+ L ++ R GV MP + P Sbjct: 189 KADVWSCGVILFALLVGALPFDDDNLRQLLEKVKR-----------GVFHMPHFIP---- 233 Query: 243 WARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285 D +SLL M+ D +R++ + H + Sbjct: 234 --------------PDCQSLLRGMIEVDAARRLTLEHIQKHIW 262 >2OU7-A nrPDB Length = 335 Score = 233 bits (595), Expect = 6e-62, Method: Composition-based stats. Identities = 69/287 (24%), Positives = 115/287 (40%), Gaps = 34/287 (11%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELNHPNIVKLLD 68 +G+G + ++ + T EV A K + + + EIS+ + L H ++V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 69 VIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 + +++V E + L + + P + YL Q++ G + H +RV+HRD Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKA--LTEPEARYYLRQIVLGCQYLHRNRVIHRD 166 Query: 128 LKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIW 187 LK NL +N + +K+ DFGLA T Y APE+L K +S VD+W Sbjct: 167 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVDVW 225 Query: 188 SLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD 247 S+GCI ++ + F + RI + S+P + Sbjct: 226 SIGCIMYTLLVGKPPFETSCLKETYLRIKK-----------NEYSIPKH----------- 263 Query: 248 FSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 ++ SL+ +ML DP R + L FF P Sbjct: 264 -------INPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPAR 303 >3A8W-A nrPDB Length = 345 Score = 233 bits (595), Expect = 7e-62, Method: Composition-based stats. Identities = 76/297 (25%), Positives = 131/297 (44%), Gaps = 30/297 (10%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD-TETEGVPSTAIREISLLKEL- 58 +++F + IG G+Y V R K T + A+K ++ + + E + ++ Sbjct: 8 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 67 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 NHP +V L TE++L+ V E+++ F +P + Y ++ L + Sbjct: 68 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMF-HMQRQRKLPEEHARFYSAEISLALNYL 126 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 H +++RDLK N+L+++EG IKL D+G+ + P T + T Y APEIL G + Sbjct: 127 HERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG-E 185 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y +VD W+LG + EM+ R+ F I + PD+ + + K Sbjct: 186 DYGFSVDWWALGVLMFEMMAGRSPFD----------IVGSSDNPDQNTEDYLFQVILEKQ 235 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA------KAALAHPFFQDV 289 ++ L S+L L+ DP +R+ HPFF++V Sbjct: 236 I----------RIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNV 282 >2WO6-A nrPDB Length = 382 Score = 233 bits (594), Expect = 8e-62, Method: Composition-based stats. Identities = 97/337 (28%), Positives = 147/337 (43%), Gaps = 52/337 (15%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59 M+ ++ IG+G++G V KA +++ E VA+K I+ + + A E+ LL+ +N Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIK---NKKAFLNQAQIEVRLLELMNK 109 Query: 60 HP-----NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 H IV L N L LVFE L +L + + G+ L L + + Q+ Sbjct: 110 HDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTA 169 Query: 115 LAFCH--SHRVLHRDLKPQNLLINT--EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 L F ++H DLKP+N+L+ AIK+ DFG + G + Y + + +YR+ Sbjct: 170 LLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQY---IQSRFYRS 226 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 PE+LLG Y A+D+WSLGCI EM T LF G +E+DQ+ +I LG P + Sbjct: 227 PEVLLGM-PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQA 285 Query: 231 TSMPDYKPSFP------KWARQDFSKVVPPLDE--------------------------- 257 + P K + + PP Sbjct: 286 PKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVAD 345 Query: 258 --DGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 + L+ +ML YDP RI AL H FF+ Sbjct: 346 YLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >1U5R-A nrPDB Length = 348 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 124/298 (41%), Gaps = 35/298 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP-STAIREISLLKELNHPN 62 F + +IG G++G VY AR+ EVVA+KK+ + I+E+ L++L HPN Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 ++ E+ +LV E+ ++ + I + LQGLA+ HSH Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHN 174 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL--LGCKYY 180 ++HRD+K N+L++ G +KL DFG A V T ++ APE++ + Y Sbjct: 175 MIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAMDEGQY 230 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VD+WSLG E+ R+ + + L+ I + Sbjct: 231 DGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ--------------------NES 270 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298 P +S+ R+ + L P R +++ L H F P + L Sbjct: 271 PALQSGHWSEYF-------RNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDL 321 >5X3F-B nrPDB Length = 393 Score = 232 bits (592), Expect = 1e-61, Method: Composition-based stats. Identities = 74/292 (25%), Positives = 122/292 (41%), Gaps = 40/292 (13%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59 ++ F +++ +G G++G V ++K +G A+K + + + E +L+ +N Sbjct: 83 LDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 142 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 P +VKL + LY+V E++ + F + P + Y Q++ + H Sbjct: 143 FPFLVKLEFSFKDNSNLYMVMEYVAGG-EMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 201 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 S +++RDLKP+NLLI+ +G I++ DFG A+ RT+T T Y APEI+L K Sbjct: 202 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWT-LCGTPEYLAPEIIL-SKG 257 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 Y+ AVD W+LG + EM F D I +I Sbjct: 258 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK-------------------- 297 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFF 286 + D + LL +L D KR H +F Sbjct: 298 ---------VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 340 >4U41-A nrPDB Length = 332 Score = 232 bits (592), Expect = 1e-61, Method: Composition-based stats. Identities = 75/297 (25%), Positives = 119/297 (40%), Gaps = 42/297 (14%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NHPN 62 F+ VE +G GTYG VYK R+ TG++ A+K + + TE EI++LK+ +H N Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV---TEDEEEEIKLEINMLKKYSHHRN 82 Query: 63 IVKLLDVIH------TENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 I +++L+LV EF + + + + I ++L+GL Sbjct: 83 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 142 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL- 174 A H H V+HRD+K QN+L+ +KL DFG++ V + T ++ APE++ Sbjct: 143 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 202 Query: 175 ---LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT 231 Y D+WS G EM + LF I R P + + Sbjct: 203 CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPR--NPPPRLKSKKWS 260 Query: 232 SMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + L + +R S + L HPF +D Sbjct: 261 KKFFSF-------------------------IEGCLVKNYMQRPSTEQLLKHPFIRD 292 >4TNB-A nrPDB Length = 590 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 73/294 (24%), Positives = 129/294 (43%), Gaps = 34/294 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHPN 62 F++ +G+G +G V + + TG++ A K++ + + S A+ E +L+++N Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +V L T++ L LV ++ DLK + G Y ++L GL H Sbjct: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHE 305 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 ++RDLKP+N+L++ G I+++D GLA V T+ Y APE+L + Y Sbjct: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-LIRGRVGTVGYMAPEVLNNQR-YG 363 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 + D W LGC+ EM+ ++ F G E + + R + +EV Sbjct: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV---------------- 407 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFFQDVT 290 E+ +S+ +L D +R+ A HPFF+++ Sbjct: 408 ---------YSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMN 452 >4AF3-A nrPDB Length = 292 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 75/294 (25%), Positives = 138/294 (46%), Gaps = 34/294 (11%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59 +++F+ +G+G +G VY AR K + +VALK + + E EGV REI + L+ Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH 81 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 HPNI++L + + ++YL+ E+ + + + + + + +L L +CH Sbjct: 82 HPNILRLYNYFYDRRRIYLILEYAPRG-ELYKELQKSCTFDEQRTATIMEELADALMYCH 140 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 +V+HRD+KP+NLL+ +G +K+ADFG + P TL Y PE++ G + Sbjct: 141 GKKVIHRDIKPENLLLGLKGELKIADFGWS--VHAPSLRRKTMCGTLDYLPPEMIEG-RM 197 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 ++ VD+W +G + E++ F S + RI + V G Sbjct: 198 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTG---------- 247 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293 + L+S++L ++P++R+ AHP+ + ++ V Sbjct: 248 -------------------AQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRV 282 >4J52-A nrPDB Length = 293 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 69/287 (24%), Positives = 115/287 (40%), Gaps = 34/287 (11%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELNHPNIVKLLD 68 +G+G + ++ + T EV A K + + + EIS+ + L H ++V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 69 VIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 + +++V E + L + + P + YL Q++ G + H +RV+HRD Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKA--LTEPEARYYLRQIVLGCQYLHRNRVIHRD 139 Query: 128 LKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIW 187 LK NL +N + +K+ DFGLA T Y APE+L K +S VD+W Sbjct: 140 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVDVW 198 Query: 188 SLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQD 247 S+GCI ++ + F + RI + S+P + Sbjct: 199 SIGCIMYTLLVGKPPFETSCLKETYLRIKK-----------NEYSIPKH----------- 236 Query: 248 FSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 ++ SL+ +ML DP R + L FF P Sbjct: 237 -------INPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPAR 276 >2GCD-A nrPDB Length = 309 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 124/298 (41%), Gaps = 35/298 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP-STAIREISLLKELNHPN 62 F + +IG G++G VY AR+ EVVA+KK+ + I+E+ L++L HPN Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 ++ E+ +LV E+ ++ + I + LQGLA+ HSH Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHN 135 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL--LGCKYY 180 ++HRD+K N+L++ G +KL DFG A V T ++ APE++ + Y Sbjct: 136 MIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAMDEGQY 191 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 VD+WSLG E+ R+ + + L+ I + Sbjct: 192 DGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ--------------------NES 231 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298 P +S+ R+ + L P R +++ L H F P + L Sbjct: 232 PALQSGHWSEYF-------RNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDL 282 >5N23-A nrPDB Length = 352 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 75/292 (25%), Positives = 119/292 (40%), Gaps = 39/292 (13%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59 ++ F+++ +G G++G V ++K TG A+K + + + E + + +N Sbjct: 41 LDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVN 100 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 P +VKL + LY+V E+ + F + P + Y Q++ + H Sbjct: 101 FPFLVKLEFSFKDNSNLYMVLEYAPGG-EMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 S +++RDLKP+NLLI+ +G IK+ADFG A+ RT T Y APEI+L K Sbjct: 160 SLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVK--GRTPWTLCGTPEYLAPEIIL-SKG 216 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 Y+ AVD W+LG + EM F D I +I Sbjct: 217 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK-------------------- 256 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFF 286 + D + LL +L D KR H +F Sbjct: 257 ---------VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 299 >4WB7-A nrPDB Length = 405 Score = 231 bits (589), Expect = 3e-61, Method: Composition-based stats. Identities = 75/292 (25%), Positives = 123/292 (42%), Gaps = 40/292 (13%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59 ++ F++++ +G G++G V ++K TG A+K + + + E +L+ +N Sbjct: 95 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 154 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 P +VKL + LY+V E++ + F + P + Y Q++ + H Sbjct: 155 FPFLVKLEFSFKDNSNLYMVMEYVPGG-EMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 213 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 S +++RDLKP+NLLI+ +G I++ DFG A+ RT+T T Y APEI+L K Sbjct: 214 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWT-LCGTPEYLAPEIIL-SKG 269 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 Y+ AVD W+LG + EM F D I +I Sbjct: 270 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK-------------------- 309 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFF 286 + D + LL +L D KR H +F Sbjct: 310 ---------VRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 352 >5DYK-A nrPDB Length = 853 Score = 230 bits (587), Expect = 5e-61, Method: Composition-based stats. Identities = 86/297 (28%), Positives = 130/297 (43%), Gaps = 39/297 (13%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELN 59 M+ + IG GT+G V +K T ALK + + I+ E + E + Sbjct: 538 MDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAEND 597 Query: 60 HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HP I++L+ Y + E + +L + L + + YL ++ + + Sbjct: 598 HPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGL--LSKSQAQFYLGSIILAIEYL 655 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 H +++RDLKP+N+L++ +G +KL DFG A+ R YT V T Y APE++LG K Sbjct: 656 HERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQ--GRAYT-LVGTPHYMAPEVILG-K 711 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y VDIW+LG E + F G+ E DQL IFR + T G + PDY Sbjct: 712 GYGCTVDIWALGICLYEFICGPLPF-GNDEEDQL-EIFRDILT-------GQLTFPDYVT 762 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA-----KAALAHPFFQDVT 290 D D +L+ ++L P RI K HPFF + Sbjct: 763 -----------------DTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFN 802 >6FYV-A nrPDB Length = 337 Score = 230 bits (586), Expect = 8e-61, Method: Composition-based stats. Identities = 82/330 (24%), Positives = 135/330 (40%), Gaps = 48/330 (14%) Query: 3 NFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH- 60 ++ V+ +GEG +G V + + + G VA+K ++ A EI +L+ LN Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGR---YREAARSEIQVLEHLNST 71 Query: 61 -PN----IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 PN V++L+ + +VFE L F+ ++ + I+ +Q+ Q + Sbjct: 72 DPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSI 131 Query: 116 AFCHSHRVLHRDLKPQNLLIN-------------------TEGAIKLADFGLARAFGVPV 156 F H +++ H DLKP+N+L IK+ DFG A Sbjct: 132 NFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA---TYDD 188 Query: 157 RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF 216 ++ V T YRAPE++L +S D+WS+GCI E +F + L + Sbjct: 189 EHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMME 247 Query: 217 RTLGTPDEVVWPGVTSMPDYKPSFPKW---------------ARQDFSKVVPPLDEDGRS 261 R LG + + + + W ++F E Sbjct: 248 RILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFD 307 Query: 262 LLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 L+ +ML YDP +RI+ AL HPFF + K Sbjct: 308 LVRRMLEYDPTQRITLDEALQHPFFDLLKK 337 >3PFQ-A nrPDB Length = 674 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 69/294 (23%), Positives = 131/294 (44%), Gaps = 38/294 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKE-L 58 + +F + +G+G++G V + K T E+ A+K ++ D + + E +L Sbjct: 340 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 399 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 P + +L T ++LY V E+++ + + P Y ++ GL F Sbjct: 400 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMY-HIQQVGRFKEPHAVFYAAEIAIGLFFL 458 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 S +++RDLK N+++++EG IK+ADFG+ + T T Y APEI+ + Sbjct: 459 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AYQ 517 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y +VD W+ G + EM+ +A F G+ E D+LF+ S+ ++ Sbjct: 518 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQ-----------------SIMEHNV 559 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA-----KAALAHPFFQ 287 ++PK + ++ ++ ++ P KR+ + H FF+ Sbjct: 560 AYPK-----------SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFR 602 >6CQF-A nrPDB Length = 297 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 78/285 (27%), Positives = 132/285 (46%), Gaps = 31/285 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +++ ++++G GTYG V+KAR+K++G++VALK ++++ + ST +EI +LK H Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKME--PDDDVSTLQKEILILKTCRHA 73 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NIV KL++ EF L+ + I ++LQGLA+ HS Sbjct: 74 NIVAYHGSYLWLQKLWICMEFCGAGSLQDI--YQVTGSLSELQISYVCREVLQGLAYLHS 131 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI--LLGCK 178 + +HRD+K N+LIN G ++LADFG++ G + + T ++ APE+ + Sbjct: 132 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKG 191 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y+ DIWSLG E+ + + LF + ++ P P + + Sbjct: 192 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQP-----PRLKEKGKWSA 246 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAH 283 +F + + L P KR SA L+H Sbjct: 247 AFH-------------------NFIKVTLTKSPKKRPSATKMLSH 272 >6CKI-A nrPDB Length = 316 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 73/316 (23%), Positives = 128/316 (40%), Gaps = 35/316 (11%) Query: 2 ENFQKVE-KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59 + +Q E +GEG + V N +T + A+K I + + + S RE+ +L + Sbjct: 12 DVYQLQEDVLGEGAHARVQTCINLITSQEYAVKII--EKQPGHIRSRVFREVEMLYQCQG 69 Query: 60 HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 H N+++L++ E++ YLVFE + + + + + L F Sbjct: 70 HRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRR--HFNELEASVVVQDVASALDFL 127 Query: 119 HSHRVLHRDLKPQNLLINTEGA---IKLADFGLARAFGVPVR-------TYTHEVVTLWY 168 H+ + HRDLKP+N+L +K+ DFGL + + Y Sbjct: 128 HNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEY 187 Query: 169 RAPEIL----LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDE 224 APE++ Y D+WSLG I +++ F G D + Sbjct: 188 MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQN 247 Query: 225 VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284 +++ S+ + K FP K + + L+S++L D +R+SA L HP Sbjct: 248 MLFE---SIQEGKYEFPD-------KDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHP 297 Query: 285 FFQ----DVTKPVPHL 296 + Q + T P P + Sbjct: 298 WVQGCAPENTLPTPMV 313 >6E2O-A nrPDB Length = 295 Score = 227 bits (579), Expect = 4e-60, Method: Composition-based stats. Identities = 80/299 (26%), Positives = 126/299 (42%), Gaps = 37/299 (12%) Query: 3 NFQKVE-----KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKE 57 +++ E +G+GTYG+VY R+ +A+K+I EI+L K Sbjct: 18 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKH 75 Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDAS-ALTGIPLPLIKSYLFQLLQGL 115 L H NIV+ L + + E + L + + I Y Q+L+GL Sbjct: 76 LKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGL 135 Query: 116 AFCHSHRVLHRDLKPQNLLINT-EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174 + H ++++HRD+K N+LINT G +K++DFG ++ TL Y APEI+ Sbjct: 136 KYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEII 195 Query: 175 -LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233 G + Y A DIWSLGC EM T + F LG P ++ M Sbjct: 196 DKGPRGYGKAADIWSLGCTIIEMATGKPPFY-------------ELGEPQAAMFK--VGM 240 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 P P+ + + ++ + + DP+KR A L F + +K Sbjct: 241 FKVHPEIPE-----------SMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKK 288 >3ALO-A nrPDB Length = 327 Score = 227 bits (578), Expect = 6e-60, Method: Composition-based stats. Identities = 72/293 (24%), Positives = 129/293 (44%), Gaps = 33/293 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E+ + + +IG G YG V K +K +G+++A+K+IR + + + +++ + P Sbjct: 22 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 81 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMD---ASALTGIPLPLIKSYLFQLLQGLAFC 118 IV+ + E ++ E + KF + IP ++ ++ L Sbjct: 82 YIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHL 141 Query: 119 HSH-RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL-- 175 + +++HRD+KP N+L++ G IKL DFG++ V T + Y APE + Sbjct: 142 KENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQL-VDSIAKTRDAGCRPYMAPERIDPS 200 Query: 176 -GCKYYSTAVDIWSLGCIFAEMVTRRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233 + Y D+WSLG E+ T R +P +S DQL ++ + G P ++ + Sbjct: 201 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK--GDPPQL---SNSEE 255 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 ++ PSF + ++ L D +KR K L HPF Sbjct: 256 REFSPSF-------------------INFVNLCLTKDESKRPKYKELLKHPFI 289 >2VD5-A nrPDB Length = 412 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 75/297 (25%), Positives = 116/297 (39%), Gaps = 38/297 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL-DTETEGVPSTAIREISLLKELNH 60 ++F+ ++ IG G + V + K TG+V A+K + D G S E +L + Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 61 PNIVKLLDVIHTENKLYLVFEF-LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 I +L EN LYLV E+ + DL + + IP + + YL +++ + H Sbjct: 121 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLL-SKFGERIPAEMARFYLAEIVMAIDSVH 179 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT-HEVVTLWYRAPEILLG-- 176 +HRD+KP N+L++ G I+LADFG + V T Y +PEIL Sbjct: 180 RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVG 239 Query: 177 ----CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 Y D W+LG EM + F DS + +I Sbjct: 240 GGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV---------------- 283 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI---SAKAALAHPFF 286 V + E+ R + ++L P R+ A HPFF Sbjct: 284 --------HYKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFF 331 >3LM0-A nrPDB Length = 327 Score = 225 bits (575), Expect = 1e-59, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 130/298 (43%), Gaps = 37/298 (12%) Query: 1 MENFQKV-----EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLL 55 MENF +++G G + VV + +K TG+ A K ++ + + + EI++L Sbjct: 23 MENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVL 82 Query: 56 KELN-HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQ 113 + P ++ L +V +++ L+ E+ ++ + + + Q+L+ Sbjct: 83 ELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILE 142 Query: 114 GLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 G+ + H + ++H DLKPQN+L+++ G IK+ DFG++R G + T Y A Sbjct: 143 GVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACE-LREIMGTPEYLA 201 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 PEIL +TA D+W++G I ++T + F G+ + I + E Sbjct: 202 PEIL-NYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSE------ 254 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + + + + +L +P KR +A+ L+H + Q Sbjct: 255 -------------------ETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQ 293 >3VN9-A nrPDB Length = 340 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 71/292 (24%), Positives = 121/292 (41%), Gaps = 35/292 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++ + + ++G G YGVV K R+ +G+++A+K+IR ++ + ++ ++ P Sbjct: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG--IPLPLIKSYLFQLLQGLAFCH 119 V + E +++ E + L KF G IP ++ +++ L H Sbjct: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 Query: 120 SH-RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL---L 175 S V+HRD+KP N+LIN G +K+ DFG++ V T + Y APE + L Sbjct: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPERINPEL 229 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 K YS DIWSLG E+ R + + QL ++ Sbjct: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS-------------- 275 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P+ F + SQ L + +R + + HPFF Sbjct: 276 ------PQLPADKF-------SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 >2I0E-A nrPDB Length = 353 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 69/294 (23%), Positives = 131/294 (44%), Gaps = 38/294 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKE-L 58 + +F + +G+G++G V + K T E+ A+K ++ D + + E +L Sbjct: 19 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 78 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 P + +L T ++LY V E+++ + + P Y ++ GL F Sbjct: 79 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMY-HIQQVGRFKEPHAVFYAAEIAIGLFFL 137 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 S +++RDLK N+++++EG IK+ADFG+ + T T Y APEI+ + Sbjct: 138 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AYQ 196 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y +VD W+ G + EM+ +A F G+ E D+LF+ S+ ++ Sbjct: 197 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQ-----------------SIMEHNV 238 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA-----KAALAHPFFQ 287 ++PK + ++ ++ ++ P KR+ + H FF+ Sbjct: 239 AYPK-----------SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFR 281 >3C51-A nrPDB Length = 543 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 120/296 (40%), Gaps = 35/296 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGV-PSTAIREISLLKELNHPN 62 F +G G +G V+ + K TG++ A KK+ + A+ E +L +++ Sbjct: 187 FLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRF 246 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALT---GIPLPLIKSYLFQLLQGLAFCH 119 IV L T+ L LV ++ ++ + G P Y Q++ GL H Sbjct: 247 IVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLH 306 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 +++RDLKP+N+L++ +G ++++D GLA T + APE+LLG + Sbjct: 307 QRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEE- 365 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 Y +VD ++LG EM+ R F E + + + V + PD Sbjct: 366 YDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQR-------VLEQAVTYPD---- 414 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDVT 290 + +L DP KR+ S HP F+D++ Sbjct: 415 --------------KFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDIS 456 >1NY3-A nrPDB Length = 400 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 71/301 (23%), Positives = 122/301 (40%), Gaps = 40/301 (13%) Query: 1 MENFQKV-EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLL-KEL 58 +++++ + +G G G V + NK T E ALK + A RE+ L + Sbjct: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 112 Query: 59 NHPNIVKLLDVIHT----ENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQ 113 P+IV+++DV L +V E L L + + + + Sbjct: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 Query: 114 GLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 + + HS + HRD+KP+NLL + +KL DFG A+ + T T +Y A Sbjct: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVA 231 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 PE+L G + Y + D+WSLG I ++ F + G Sbjct: 232 PEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMKTR 278 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 M Y+ P+W+ + E+ + L+ +L +P +R++ + HP+ T Sbjct: 279 IRMGQYEFPNPEWS---------EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 Query: 291 K 291 K Sbjct: 330 K 330 >5FET-A nrPDB Length = 847 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 84/297 (28%), Positives = 131/297 (44%), Gaps = 39/297 (13%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELN 59 M + IG GT+G V +K T ALK + + I+ E + E + Sbjct: 532 MHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAEND 591 Query: 60 HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HP I++L+ N Y + E + +L + L + P + YL ++ + + Sbjct: 592 HPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGL--LSKPQAQFYLGSIILAIEYL 649 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 H +++RDLKP+N+L++ +G +KL DFG A+ R YT V T Y APE++LG K Sbjct: 650 HERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQ--GRAYT-LVGTPHYMAPEVILG-K 705 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 Y VDIW+LG E + F G+ + DQL IFR + T + Sbjct: 706 GYGCTVDIWALGVCLYEFICGPLPF-GNDQEDQL-EIFRDILT--------------GQL 749 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA-----KAALAHPFFQDVT 290 +FP + D+D +L+ ++L P RI K H FF + Sbjct: 750 TFPDYVS----------DQDSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNFN 796 >3KA0-A nrPDB Length = 320 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 71/301 (23%), Positives = 122/301 (40%), Gaps = 40/301 (13%) Query: 1 MENFQKV-EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLL-KEL 58 +++++ + +G G G V + NK T E ALK + A RE+ L + Sbjct: 14 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 66 Query: 59 NHPNIVKLLDVIHT----ENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQ 113 P+IV+++DV L +V E L L + + + + Sbjct: 67 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 126 Query: 114 GLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 + + HS + HRD+KP+NLL + +KL DFG A+ + T T +Y A Sbjct: 127 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTEPCYTPYYVA 185 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 PE+L G + Y + D+WSLG I ++ F + G Sbjct: 186 PEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMKTR 232 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 M Y+ P+W+ + E+ + L+ +L +P +R++ + HP+ T Sbjct: 233 IRMGQYEFPNPEWS---------EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 283 Query: 291 K 291 K Sbjct: 284 K 284 >3PPZ-A nrPDB Length = 309 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 65/303 (21%), Positives = 119/303 (39%), Gaps = 38/303 (12%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + EKIG G++G V++A G VA+K + + +RE++++K L HPN Sbjct: 38 DLNIKEKIGAGSFGTVHRAE--WHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPN 95 Query: 63 IVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASA-LTGIPLPLIKSYLFQLLQGLAFCHS 120 IV + + L +V E+L L + + S + S + + +G+ + H+ Sbjct: 96 IVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHN 155 Query: 121 HR--VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 ++HRDLK NLL++ + +K+ DFGL+R + T + APE+L + Sbjct: 156 RNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRD-E 214 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 + D++S G I E+ T + + G + + Sbjct: 215 PSNEKSDVYSFGVILWELATLQQPW----------------GNLNPAQVVAAVGFKCKRL 258 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI---SAKAALAHPFFQDVTKPVPH 295 P+ L+ +++ +P KR + L P + P Sbjct: 259 EIPR-----------NLNPQVAAIIEGCWTNEPWKRPSFATIMDLLR-PLIKSAVPPPNR 306 Query: 296 LRL 298 L Sbjct: 307 SDL 309 >2FO0-A nrPDB Length = 495 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 63/281 (22%), Positives = 118/281 (41%), Gaps = 35/281 (12%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + K+G G YG VY+ K VA+K ++ DT ++E +++KE+ HPN Sbjct: 218 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM---EVEEFLKEAAVMKEIKHPN 274 Query: 63 IVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +V+LL V E Y++ EF+ + +L ++ + ++ Q+ + + Sbjct: 275 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 334 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILLGCKYY 180 +HR+L +N L+ +K+ADFGL+R G + + + APE L + Sbjct: 335 NFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL-AYNKF 393 Query: 181 STAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 S D+W+ G + E+ T + +PG ++ Q++ + DY+ Sbjct: 394 SIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLE----------------KDYRME 436 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA 280 P+ E L+ ++P+ R S Sbjct: 437 RPEGCP-----------EKVYELMRACWQWNPSDRPSFAEI 466 >2BRG-A nrPDB Length = 297 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 78/297 (26%), Positives = 128/297 (43%), Gaps = 33/297 (11%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 +E++ V+ +GEG YG V A N++T E VA+K + + + P +EI + K LNH Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD-CPENIKKEICINKMLNH 64 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 N+VK N YL E+ + F G+P P + + QL+ G+ + H Sbjct: 65 ENVVKFYGHRREGNIQYLFLEYCSGG-ELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY--THEVVTLWYRAPEILLGCK 178 + HRD+KP+NLL++ +K++DFGLA F R TL Y APE+L + Sbjct: 124 IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRRE 183 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 +++ VD+WS G + M+ + S+ Q + Y Sbjct: 184 FHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ--------------EYSDWKEKKTYLN 229 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPH 295 + K + LL ++L +P+ RI+ + KP+ Sbjct: 230 PWKKIDSAPLA------------LLHKILVENPSARITIPDIKKDRW---YNKPLKK 271 >4XEY-B nrPDB Length = 408 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 64/281 (22%), Positives = 118/281 (41%), Gaps = 35/281 (12%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + K+G G YG VY+ K VA+K ++ DT ++E +++KE+ HPN Sbjct: 126 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM---EVEEFLKEAAVMKEIKHPN 182 Query: 63 IVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +V+LL V E Y++ EF+ + +L ++ + ++ Q+ + + Sbjct: 183 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 242 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILLGCKYY 180 +HRDL +N L+ +K+ADFGL+R G + + + APE L + Sbjct: 243 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL-AYNKF 301 Query: 181 STAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 S D+W+ G + E+ T + +PG ++ Q++ + DY+ Sbjct: 302 SIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLE----------------KDYRME 344 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA 280 P+ E L+ ++P+ R S Sbjct: 345 RPEGCP-----------EKVYELMRACWQWNPSDRPSFAEI 374 >2OZA-A nrPDB Length = 356 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 71/301 (23%), Positives = 122/301 (40%), Gaps = 40/301 (13%) Query: 1 MENFQKV-EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLL-KEL 58 +++++ + +G G G V + NK T E ALK + A RE+ L + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 68 Query: 59 NHPNIVKLLDVIHT----ENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQ 113 P+IV+++DV L +V E L L + + + + Sbjct: 69 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 128 Query: 114 GLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 + + HS + HRD+KP+NLL + +KL DFG A+ + T T +Y A Sbjct: 129 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVA 187 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 PE+L G + Y + D+WSLG I ++ F + G Sbjct: 188 PEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMKTR 234 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 M Y+ P+W+ + E+ + L+ +L +P +R++ + HP+ T Sbjct: 235 IRMGQYEFPNPEWS---------EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 285 Query: 291 K 291 K Sbjct: 286 K 286 >4WNO-A nrPDB Length = 287 Score = 223 bits (570), Expect = 5e-59, Method: Composition-based stats. Identities = 80/296 (27%), Positives = 124/296 (41%), Gaps = 42/296 (14%) Query: 3 NFQKVEKIGEGTYGVVYKARNKL-TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 F + + IG G + VV+K R++ VA+K I + +EI +LKEL H Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQT-LLGKEIKILKELKHE 77 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NIV L D N +YLV E+ + DL ++ A + + I+ +L Q+ + HS Sbjct: 78 NIVALYDFQEMANSVYLVMEYCNGGDLADYLHA--MRTLSEDTIRLFLQQIAGAMRLLHS 135 Query: 121 HRVLHRDLKPQNLLINTEG---------AIKLADFGLARAFGVPVRTYTHEVVTLWYRAP 171 ++HRDLKPQN+L++ +K+ADFG AR + T + Y AP Sbjct: 136 KGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT-LCGSPMYMAP 194 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT 231 E+++ ++Y D+WS+G I + +T +A F S D R+F P T Sbjct: 195 EVIM-SQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD--LRLFYEKNKTLVPTIPRET 251 Query: 232 SMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 S P + R + R+ HPF Sbjct: 252 SAPLRQLLLALLQR------------------------NHKDRMDFDEFFHHPFLD 283 >3FXW-A nrPDB Length = 336 Score = 223 bits (569), Expect = 7e-59, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 120/297 (40%), Gaps = 41/297 (13%) Query: 2 ENFQK-VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 +++Q + +G G G V + ++ TG+ ALK + + A +E+ + + Sbjct: 28 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPK-------ARQEVDHHWQASG 80 Query: 61 -PNIVKLLDVIHTENK----LYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQG 114 P+IV +LDV + L ++ E + L + + + Sbjct: 81 GPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTA 140 Query: 115 LAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAP 171 + F HSH + HRD+KP+NLL + + +KL DFG A+ T +Y AP Sbjct: 141 IQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKE--TTQNALQTPCYTPYYVAP 198 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT 231 E+L G + Y + D+WSLG I ++ F ++ G Sbjct: 199 EVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNT------------GQAISPGMKRRI 245 Query: 232 SMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + Y P+W+ + ED + L+ +L DP +R++ + HP+ Sbjct: 246 RLGQYGFPNPEWS---------EVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQ 293 >2XYN-A nrPDB Length = 292 Score = 223 bits (569), Expect = 7e-59, Method: Composition-based stats. Identities = 64/261 (24%), Positives = 118/261 (45%), Gaps = 23/261 (8%) Query: 1 MENFQKVE-------KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREIS 53 M+ ++ K+G G YG VY K VA+K ++ DT ++E + Sbjct: 24 MDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM---EVEEFLKEAA 80 Query: 54 LLKELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLL 112 ++KE+ HPN+V+LL V E Y+V E++ + +L ++ + ++ Q+ Sbjct: 81 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 140 Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVVTLWYRAP 171 + + +HRDL +N L+ +K+ADFGL+R G + + + AP Sbjct: 141 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 200 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPG------DSEIDQLFRIFRTLGTPD- 223 E L +S D+W+ G + E+ T + +PG +++ +R+ + G P Sbjct: 201 ESL-AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPK 259 Query: 224 --EVVWPGVTSMPDYKPSFPK 242 E++ P +PSF + Sbjct: 260 VYELMRACWKWSPADRPSFAE 280 >6O6Q-A nrPDB Length = 335 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 82/301 (27%), Positives = 150/301 (49%), Gaps = 22/301 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NH 60 EN++ + K+G G Y V+ + E V +K ++ + REIS+LK L + Sbjct: 41 ENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKK-----IKREISILKNLVDG 95 Query: 61 PNIVKLLDVIHTENKLY--LVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 PNI+ +LDV+ L+FE ++ S I+ Y+++LL+ L + Sbjct: 96 PNIIAMLDVVREPQSKTPGLIFEHINN----IDFRSLYPTFTDYDIRFYMYELLKALDYS 151 Query: 119 HSHRVLHRDLKPQNLLINTEGA-IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 HS ++HRD+KP N++I+ + ++L D+GLA + P Y V + +++ PE+L+ Sbjct: 152 HSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLA-EYYHPGTEYNVRVASRYFKGPELLVDY 210 Query: 178 KYYSTAVDIWSLGCIFAEM-VTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 + Y ++D+WS GC+ A M + F G S DQL +I R LG+ + + ++ Sbjct: 211 RLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLG 270 Query: 237 K-------PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 + + +W R + ++ L+ ++L YD +R++AK A+ H +F + Sbjct: 271 EEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYFDPI 330 Query: 290 T 290 Sbjct: 331 R 331 >6GVJ-A nrPDB Length = 429 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 79/307 (25%), Positives = 129/307 (42%), Gaps = 44/307 (14%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN--HP 61 + +++IG G V++ N ++ A+K + L+ + EI+ L +L Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 I++L D T+ +Y+V E + DL ++ I KSY +L+ + H H Sbjct: 205 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKK--KSIDPWERKSYWKNMLEAVHTIHQH 262 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT--YTHEVVTLWYRAPEILLGCK- 178 ++H DLKP N LI +G +KL DFG+A + +V T+ Y PE + Sbjct: 263 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 321 Query: 179 ---------YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 S D+WSLGCI M + F I+Q+ ++ + Sbjct: 322 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAII---------- 369 Query: 230 VTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 P+++ FP +D + +L L DP +RIS LAHP+ Q Sbjct: 370 ---DPNHEIEFPDIPEKDL-----------QDVLKCCLKRDPKQRISIPELLAHPYVQIQ 415 Query: 290 TKPVPHL 296 T PV + Sbjct: 416 THPVNQM 422 >4C0T-A nrPDB Length = 974 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 125/299 (41%), Gaps = 44/299 (14%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHP 61 +F+ +++GEG+Y V A +K+TG+ A+K + + E E L L++ Sbjct: 267 DFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNR 326 Query: 62 -NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 ++ L ++ LY V ++ + +L + + + + Q+L + + H Sbjct: 327 LGVISLYFTFQDKDSLYFVLDYASNGELLTLIKR--YNTLNEECTRHFGAQILDAIKYMH 384 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY---------THEVVTLWYRA 170 + V+HRDLKP+N+L++ + I++ DFG AR V T Y + Sbjct: 385 DNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVS 444 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 PE+L KY D+W+ GCI +M+ + F +E +I + Sbjct: 445 PELLEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKL------------ 491 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 + FS P + R L+ ++L P++R + H FFQ V Sbjct: 492 --------------QFAFSAGFPTI---IRDLIKKILVLQPSRRATIPEIQKHYFFQSV 533 >6NPU-A nrPDB Length = 298 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 64/281 (22%), Positives = 118/281 (41%), Gaps = 35/281 (12%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + K+G G YG VY+ K VA+K ++ DT ++E +++KE+ HPN Sbjct: 27 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM---EVEEFLKEAAVMKEIKHPN 83 Query: 63 IVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +V+LL V E Y++ EF+ + +L ++ + ++ Q+ + + Sbjct: 84 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 143 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILLGCKYY 180 +HRDL +N L+ +K+ADFGL+R G + + + APE L + Sbjct: 144 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL-AYNKF 202 Query: 181 STAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 S D+W+ G + E+ T + +PG ++ Q++ + DY+ Sbjct: 203 SIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLE----------------KDYRME 245 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA 280 P+ E L+ ++P+ R S Sbjct: 246 RPEGCP-----------EKVYELMRACWQWNPSDRPSFAEI 275 >6BDL-A nrPDB Length = 347 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 124/298 (41%), Gaps = 39/298 (13%) Query: 1 MENFQKVEKIGEGTYGVVYKARNK-LTGEVVALKKIRLDTETEGVPSTAIR-EISLLKEL 58 + +F ++ +G G +G V + K + A+K ++ + IR E +++ Sbjct: 33 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 92 Query: 59 NHPNIVKLLDVIHTENKLYLVFE-FLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 + IV+L LY++ E L +L + + Y +++ A+ Sbjct: 93 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRG--SFEDSTTRFYTACVVEAFAY 150 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 HS +++RDLKP+NL+++ G KL DFG A+ G +T+T T Y APEI+L Sbjct: 151 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWT-FCGTPEYVAPEIILN- 208 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 K + + D WSLG + E++T F G + I R + Sbjct: 209 KGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGI------------------ 250 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDVT 290 D + + ++ +L+ ++ +P++R+ K H +F+ Sbjct: 251 ---------DMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFN 299 >2H8H-A nrPDB Length = 535 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 70/291 (24%), Positives = 121/291 (41%), Gaps = 39/291 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E+ + K+G+G +G V+ T VA+K ++ T + P ++E ++K+L H Sbjct: 267 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHE 322 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +V+L V+ +E +Y+V E++ L F+ + LP + Q+ G+A+ Sbjct: 323 KLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 381 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT-YTHEVVTLWYRAPEILLGCKY 179 +HRDL+ N+L+ K+ADFGLAR T + + APE L Sbjct: 382 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-YGR 440 Query: 180 YSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 ++ D+WS G + E+ T R +PG + L ++ R P P Sbjct: 441 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP---------- 490 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 E L+ Q +P +R + + A F +D Sbjct: 491 ------------------ESLHDLMCQCWRKEPEERPTFEYLQA--FLEDY 521 >3FME-A nrPDB Length = 290 Score = 221 bits (564), Expect = 2e-58, Method: Composition-based stats. Identities = 70/292 (23%), Positives = 120/292 (41%), Gaps = 35/292 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++ + + ++G G YGVV K R+ +G+++A+K+IR ++ + ++ ++ P Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 66 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG--IPLPLIKSYLFQLLQGLAFCH 119 V + E +++ E + L KF G IP ++ +++ L H Sbjct: 67 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 126 Query: 120 SH-RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL---L 175 S V+HRD+KP N+LIN G +K+ DFG++ V + Y APE + L Sbjct: 127 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAK-DIDAGCKPYMAPERINPEL 185 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 K YS DIWSLG E+ R + + QL ++ Sbjct: 186 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS-------------- 231 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 P+ F + SQ L + +R + + HPFF Sbjct: 232 ------PQLPADKF-------SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 270 >6F3F-A nrPDB Length = 455 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 70/291 (24%), Positives = 122/291 (41%), Gaps = 39/291 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E+ + K+G+G +G V+ T VA+K ++ T + P ++E ++K+L H Sbjct: 187 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHE 242 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +V+L V+ +E +Y+V E+++ L F+ + LP + Q+ G+A+ Sbjct: 243 KLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVER 301 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT-YTHEVVTLWYRAPEILLGCKY 179 +HRDL+ N+L+ K+ADFGLAR T + + APE L Sbjct: 302 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-YGR 360 Query: 180 YSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 ++ D+WS G + E+ T R +PG + L ++ R P P Sbjct: 361 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP---------- 410 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 E L+ Q +P +R + + A F +D Sbjct: 411 ------------------ESLHDLMCQCWRKEPEERPTFEYLQA--FLEDY 441 >6CCF-A nrPDB Length = 290 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 74/316 (23%), Positives = 130/316 (41%), Gaps = 57/316 (18%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGV---------------- 44 + ++ +IG+G YGVV A N+ A+K + + Sbjct: 4 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 63 Query: 45 --------PSTAIREISLLKELNHPNIVKLLDVIHT--ENKLYLVFEFLHQDLKKFMDAS 94 +EI++LK+L+H N+VKL++V+ E+ LYLVF+ L + M+ Sbjct: 64 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKG--PVMEVP 121 Query: 95 ALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV 154 + YL ++ GL + H +++HRD+KP NLL+ +G +K+ADFG++ F Sbjct: 122 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG 181 Query: 155 PVRTYTHEVVTLWYRAPEIL--LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQL 212 + T + APE + G + A+D+W+ G V + F Sbjct: 182 NDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF--------- 232 Query: 213 FRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPN 272 D+ + + + FP+ P + E+ + L+ +ML +P Sbjct: 233 ---------IDDFILALHRKIKNEPVVFPE---------EPEISEELKDLILKMLDKNPE 274 Query: 273 KRISAKAALAHPFFQD 288 RI HP+ Sbjct: 275 TRIGVPDIKLHPWVTK 290 >5MJB-A nrPDB Length = 305 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 65/278 (23%), Positives = 125/278 (44%), Gaps = 21/278 (7%) Query: 5 QKVEKIGEGTYGVVYKARNKLTGE---VVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + E IG G +G VYK R KL G+ VA+K ++ +E + E S++ + +H Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-SEKQRRDFLSEASIMGQFDHR 87 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NI++L V+ + ++ EF+ L F+ + + + L + G+ + Sbjct: 88 NIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQ-FTVIQLVGMLRGIAAGMKYLSE 146 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR--TYTHEVV---TLWYRAPEILL 175 +HRDL +N+L+N+ K++DFGL+R TYT + + + APE + Sbjct: 147 MNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAI- 205 Query: 176 GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 + +++A D+WS G + E+++ + S D + I + P + P Sbjct: 206 AYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAAL--- 262 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPN 272 ++ W + S+ P + + L +M+ +P Sbjct: 263 -HQLMLDCWQKDRNSR---PRFAEIVNTLDKMI-RNPA 295 >5UNP-A nrPDB Length = 369 Score = 220 bits (562), Expect = 4e-58, Method: Composition-based stats. Identities = 86/335 (25%), Positives = 141/335 (42%), Gaps = 48/335 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKAR-NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59 E ++ V +GEGT+G V + ++ G VALK I+ E A EI++L+++N Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK---NVEKYKEAARLEINVLEKINE 90 Query: 60 ----HPNI-VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 + N+ V++ D + + FE L F+ + P+ ++ FQL Q Sbjct: 91 KDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQA 150 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEG-------------------AIKLADFGLARAFGVP 155 + F H +++ H DLKP+N+L A+++ DFG A Sbjct: 151 VKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF---D 207 Query: 156 VRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRI 215 ++ V T YRAPE++L +S D+WS+GCI E LF + L + Sbjct: 208 HEHHSTIVSTRHYRAPEVILELG-WSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMM 266 Query: 216 FRTLGTPDEVVWPGVTSMP---------DYKPSFPKWARQDFSKVVPPLDEDGR------ 260 R LG + D S ++ R++ + L + Sbjct: 267 ERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLF 326 Query: 261 SLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPH 295 L+ ML Y+P KR++ AL HPFF + P+ Sbjct: 327 DLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 361 >4FR4-A nrPDB Length = 384 Score = 220 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 68/294 (23%), Positives = 130/294 (44%), Gaps = 34/294 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP-STAIREISLLKELNH 60 ++F+ + IG+G++G V + T ++ A+K + E +E+ +++ L H Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 74 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 P +V L E +++V + L DL+ + + +K ++ +L+ L + Sbjct: 75 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV--HFKEETVKLFICELVMALDYLQ 132 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK- 178 + R++HRD+KP N+L++ G + + DF +A + T T Y APE+ K Sbjct: 133 NQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQ-ITTMAGTKPYMAPEMFSSRKG 191 Query: 179 -YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 YS AVD WSLG E++ R + R+ + E+V T++ Y Sbjct: 192 AGYSFAVDWWSLGVTAYELLRGRRPYH-----------IRSSTSSKEIVHTFETTVVTYP 240 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-AKAALAHPFFQDVT 290 ++ ++ SLL ++L +P++R S P+ D+ Sbjct: 241 SAW---------------SQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDIN 279 >4P5Q-A nrPDB Length = 361 Score = 220 bits (561), Expect = 5e-58, Method: Composition-based stats. Identities = 63/277 (22%), Positives = 121/277 (43%), Gaps = 19/277 (6%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEV---VALKKIRLDTETEGVPSTAIREISLLKELN 59 N + +G G +G V R KL + VA+K +++ TE + E S++ + + Sbjct: 34 NISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-TEKQRRDFLGEASIMGQFD 92 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HPNI++L V+ + +V E++ L F+ + + L + G+ + Sbjct: 93 HPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQ-FTVIQLVGMLRGIASGMKYL 151 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVV--TLWYRAPEILL 175 +HRDL +N+LIN+ K++DFGL+R P YT + + +PE + Sbjct: 152 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAI- 210 Query: 176 GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 + +++A D+WS G + E+++ + S D + + P + P Sbjct: 211 AYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAAL--- 267 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDP 271 Y+ W + + P E S+L +++ +P Sbjct: 268 -YQLMLDCWQKD---RNNRPKFEQIVSILDKLI-RNP 299 >5KKR-C nrPDB Length = 395 Score = 220 bits (561), Expect = 5e-58, Method: Composition-based stats. Identities = 79/303 (26%), Positives = 138/303 (45%), Gaps = 23/303 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++F+K+ ++G G GVV+K +K +G V+A K I L+ + + + IRE+ +L E N P Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 126 Query: 62 NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC-H 119 IV +++ ++ + E + L + + + IP ++ +++GL + Sbjct: 127 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLRE 184 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 H+++HRD+KP N+L+N+ G IKL DFG++ V T Y +PE L G + Sbjct: 185 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQGT-H 241 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEID-QLFRIFRTLGTPDEVVWPGVTSM----- 233 YS DIWS+G EM R P + +L + G E T Sbjct: 242 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 301 Query: 234 --PDYKPSFPKWARQDFSKVVPP-------LDEDGRSLLSQMLHYDPNKRISAKAALAHP 284 D +P + D+ PP + + +++ L +P +R K + H Sbjct: 302 YGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 361 Query: 285 FFQ 287 F + Sbjct: 362 FIK 364 >6FEX-A nrPDB Length = 321 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 75/301 (24%), Positives = 130/301 (43%), Gaps = 39/301 (12%) Query: 3 NFQKVEKIGEGTYGVVYKAR--------------NKLTGE--VVALKKIRLDTETEGVPS 46 + EK+GEG +G V+ N G +VA+K +R D T+ + Sbjct: 17 RLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDA-TKNARN 75 Query: 47 TAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTG------- 98 ++E+ ++ L PNI++LL V ++ L ++ +++ DL +F+ A L Sbjct: 76 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAP 135 Query: 99 ----IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-- 152 I P++ Q+ G+ + + +HRDL +N L+ IK+ADFG++R Sbjct: 136 GDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYA 195 Query: 153 GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAE--MVTRRALF---PGDS 207 G R V+ + + A E +L ++TA D+W+ G E M+ R F + Sbjct: 196 GDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQ 254 Query: 208 EIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQML 267 I+ FR G + P Y+ W+R+ S+ PP + R L L Sbjct: 255 VIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRE--SEQRPPFSQLHRFLAEDAL 312 Query: 268 H 268 + Sbjct: 313 N 313 >4E93-A nrPDB Length = 377 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 117/288 (40%), Gaps = 38/288 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E+ E+IG G +G V+ R + +VA+K R +T + + ++E +LK+ +HP Sbjct: 114 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCR-ETLPPDLKAKFLQEARILKQYSHP 172 Query: 62 NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NIV+L+ V + +Y+V E + D F+ + + + + G+ + S Sbjct: 173 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGAR-LRVKTLLQMVGDAAAGMEYLES 231 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTH--EVVTLWYRAPEILLGCK 178 +HRDL +N L+ + +K++DFG++R V + V + + APE L Sbjct: 232 KCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEAL-NYG 290 Query: 179 YYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 YS+ D+WS G + E + + +P S + + P + P Sbjct: 291 RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFR---- 346 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI---SAKAALA 282 L+ Q Y+P +R + L Sbjct: 347 ------------------------LMEQCWAYEPGQRPSFSTIYQELQ 370 >5H2U-A nrPDB Length = 267 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 68/283 (24%), Positives = 113/283 (39%), Gaps = 34/283 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E F K+G G +G V++ K + VA+K I D EI +K+L H Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKDRVQ-VAIKVISRDNLLHQ--QMLQSEIQAMKKLRHK 62 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +I+ L V+ + +Y++ E + L + + S +P+ + +Q+ +G+ + S Sbjct: 63 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 122 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 +HRDL +N+L+ K+ DFGLAR V + + APE L +Y Sbjct: 123 QNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL-SRGHY 181 Query: 181 STAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 ST D+WS G + EM + + +PG S + R+ P + P Sbjct: 182 STKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECP----------- 230 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 282 L+ DP +R + KA Sbjct: 231 -----------------PSVHKLMLTCWCRDPEQRPTFKALRE 256 >6BSD-A nrPDB Length = 876 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 75/307 (24%), Positives = 130/307 (42%), Gaps = 45/307 (14%) Query: 3 NFQKVEKIGEGTYGVVYKAR--------------NKLTGE--VVALKKIRLDTETEGVPS 46 + EK+GEG +G V+ N G +VA+K +R D T+ + Sbjct: 572 RLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDA-TKNARN 630 Query: 47 TAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTG------- 98 ++E+ ++ L PNI++LL V ++ L ++ +++ DL +F+ A L Sbjct: 631 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAP 690 Query: 99 ----------IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGL 148 I P++ Q+ G+ + + +HRDL +N L+ IK+ADFG+ Sbjct: 691 GDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGM 750 Query: 149 ARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAE--MVTRRALF- 203 +R G R V+ + + A E +L ++TA D+W+ G E M+ R F Sbjct: 751 SRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRAQPFG 809 Query: 204 --PGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRS 261 + I+ FR G + P Y+ W+R+ S+ PP + R Sbjct: 810 QLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRE--SEQRPPFSQLHRF 867 Query: 262 LLSQMLH 268 L L+ Sbjct: 868 LAEDALN 874 >2WTK-C nrPDB Length = 305 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 80/299 (26%), Positives = 135/299 (45%), Gaps = 36/299 (12%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTET--EGVPSTAIREISLLKELNH 60 + + +GEG+YG V + + T A+K ++ + +EI LL+ L H Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 61 PNIVKLLDVI--HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 N+++L+DV+ + K+Y+V E+ +++ +D+ P+ Y QL+ GL + Sbjct: 66 KNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYL 125 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG--VPVRTYTHEVVTLWYRAPEILLG 176 HS ++H+D+KP NLL+ T G +K++ G+A A T + ++ PEI G Sbjct: 126 HSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANG 185 Query: 177 CKYYS-TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 +S VDIWS G + T F GD+ ++++F +G G ++P Sbjct: 186 LDTFSGFKVDIWSAGVTLYNITTGLYPFEGDN----IYKLFENIG-------KGSYAIP- 233 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 PPL LL ML Y+P KR S + H +F+ P Sbjct: 234 -------------GDCGPPLS----DLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAE 275 >2PVN-A nrPDB Length = 352 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 85/301 (28%), Positives = 147/301 (48%), Gaps = 21/301 (6%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++++ V K+G G Y V++ N E K I + L P Sbjct: 52 DDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKKKKIKREIKILQNLCGGP 107 Query: 62 NIVKLLDVIHTE--NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 NIVKLLD++ + L+FE+++ K + + I+ Y+++LL+ L +CH Sbjct: 108 NIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVL----YPTLTDYDIRYYIYELLKALDYCH 163 Query: 120 SHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 S ++HRD+KP N++I+ E ++L D+GLA F P + Y V + +++ PE+L+ + Sbjct: 164 SQGIMHRDVKPHNVMIDHELRKLRLIDWGLA-EFYHPGKEYNVRVASRYFKGPELLVDLQ 222 Query: 179 YYSTAVDIWSLGCIFAEMVTRRAL-FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY- 236 Y ++D+WSLGC+FA M+ R+ F G DQL +I + LGT + + Sbjct: 223 DYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELDP 282 Query: 237 -------KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 + S W + + + + L ++L YD +R++A A+ HP+FQ V Sbjct: 283 QLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQV 342 Query: 290 T 290 Sbjct: 343 R 343 >6QAU-A nrPDB Length = 280 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 75/297 (25%), Positives = 130/297 (43%), Gaps = 42/297 (14%) Query: 3 NFQKVEKIGEGTYGVVYKARNKL-TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + K + +G G + VV++ R++ T VA+K I ++ +EI +LKEL H Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ-ILLGKEIKILKELQHE 70 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NIV L DV N ++LV E+ + DL ++ A + I+ +L Q+ + HS Sbjct: 71 NIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGT--LSEDTIRVFLHQIAAAMRILHS 128 Query: 121 HRVLHRDLKPQNLLIN---------TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAP 171 ++HRDLKPQN+L++ + IK+ADFG AR + + Y AP Sbjct: 129 KGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMA-ADLCGSPMYMAP 187 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT 231 E+++ ++Y D+WS+G + + + + F +S D L + Sbjct: 188 EVIM-SQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD-LRMFYE-------------- 231 Query: 232 SMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 PS P+ + ++ L + R+ +A +HPF + Sbjct: 232 KNRSLMPSIPRETSPYLANLLLGLL-----------QRNQKDRMDFEAFFSHPFLEQ 277 >2DQ7-X nrPDB Length = 283 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 65/251 (25%), Positives = 116/251 (46%), Gaps = 18/251 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E+ Q ++++G G +G V+ VA+K ++ T + P + + E ++K+L H Sbjct: 9 ESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMS---PESFLEEAQIMKKLKHD 64 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +V+L V+ +E +Y+V E+++ L F+ + LP + Q+ G+A+ Sbjct: 65 KLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER 123 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT-YTHEVVTLWYRAPEILLGCKY 179 +HRDL+ N+L+ K+ADFGLAR T + + APE L Sbjct: 124 MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-YGR 182 Query: 180 YSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWP---------G 229 ++ D+WS G + E+VT R +PG + + L ++ R P P Sbjct: 183 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 242 Query: 230 VTSMPDYKPSF 240 P+ +P+F Sbjct: 243 WKKDPEERPTF 253 >4MD7-E nrPDB Length = 391 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 89/308 (28%), Positives = 152/308 (49%), Gaps = 23/308 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH- 60 +++Q V K+G G Y V++A N E + + REI +L+ L Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKKKIKREIKILENLRGG 91 Query: 61 PNIVKLLDVIHTE--NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 PNI+ L D++ LVFE ++ K + I+ Y++++L+ L +C Sbjct: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFK----QLYQTLTDYDIRFYMYEILKALDYC 147 Query: 119 HSHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 HS ++HRD+KP N++I+ E ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 148 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDY 206 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRAL-FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 + Y ++D+WSLGC+ A M+ R+ F G DQL RI + LGT D + ++ Sbjct: 207 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 266 Query: 237 --------KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + S +W R S+ + + L ++L YD R++A+ A+ HP+F Sbjct: 267 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 326 Query: 289 VTKPVPHL 296 V K + Sbjct: 327 VVKDQARM 334 >3A4O-X nrPDB Length = 286 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 65/253 (25%), Positives = 121/253 (47%), Gaps = 21/253 (8%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E+ + V+++G G +G V+ + VA+K ++ T + + E +L+K L H Sbjct: 13 ESIKLVKRLGAGQFGEVWMGYYNNS-TKVAVKTLKPGTMS---VQAFLEEANLMKTLQHD 68 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +V+L V+ E +Y++ E++ L F+ + + LP + + Q+ +G+A+ Sbjct: 69 KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER 128 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV---TLWYRAPEILLGC 177 +HRDL+ N+L++ K+ADFGLAR YT + + APE + Sbjct: 129 KNYIHRDLRAANVLVSESLMCKIADFGLARVIED--NEYTAREGAKFPIKWTAPEAI-NF 185 Query: 178 KYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEID------QLFRIFRTLGTPDE---VVW 227 ++ D+WS G + E+VT + +PG + D Q +R+ R PDE ++ Sbjct: 186 GCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMK 245 Query: 228 PGVTSMPDYKPSF 240 + +P+F Sbjct: 246 MCWKEKAEERPTF 258 >2XNP-A nrPDB Length = 279 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 79/295 (26%), Positives = 126/295 (42%), Gaps = 39/295 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E+++ + IG G+YG K R K G+++ K++ + TE + E++LL+EL HP Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 62 NIVKLLDVI--HTENKLYLVFEFLHQ-DLKKFMDASALTG--IPLPLIKSYLFQLLQGLA 116 NIV+ D I T LY+V E+ DL + + + + QL L Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125 Query: 117 FCHS-----HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAP 171 CH H VLHRDLKP N+ ++ + +KL DFGLAR V T +Y +P Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT 231 E + Y+ DIWSLGC+ E+ F S+ + +I Sbjct: 186 EQ-MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGK------------ 232 Query: 232 SMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 F ++ ++ ++++ML+ R S + L +P Sbjct: 233 ----------------FRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLI 271 >5L6P-A nrPDB Length = 298 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 63/278 (22%), Positives = 121/278 (43%), Gaps = 21/278 (7%) Query: 5 QKVEKIGEGTYGVVYKARNKLTGEV---VALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + E IG G +G V + R K G VA+K +++ TE + E S++ + +HP Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGY-TERQRRDFLSEASIMGQFDHP 80 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NI++L V+ + ++ EF+ L F+ + + + L + G+ + Sbjct: 81 NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQ-FTVIQLVGMLRGIAAGMKYLSE 139 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYTHEVV---TLWYRAPEILL 175 +HRDL +N+L+N+ K++DFGL+R TYT + + + APE + Sbjct: 140 MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAI- 198 Query: 176 GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 + +++A D+WS G + E+++ + S D + + + P + P Sbjct: 199 AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTAL--- 255 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPN 272 ++ W R + P + +L L +P Sbjct: 256 -HQLMLDCWVRD--RNLRPKFSQIVNTLDK--LIRNPA 288 >3EQC-A nrPDB Length = 360 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 79/303 (26%), Positives = 138/303 (45%), Gaps = 23/303 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++F+K+ ++G G GVV+K +K +G V+A K I L+ + + + IRE+ +L E N P Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 91 Query: 62 NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC-H 119 IV +++ ++ + E + L + + + IP ++ +++GL + Sbjct: 92 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLRE 149 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 H+++HRD+KP N+L+N+ G IKL DFG++ V T Y +PE L G + Sbjct: 150 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQGT-H 206 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEID-QLFRIFRTLGTPDEVVWPGVTSM----- 233 YS DIWS+G EM R P + +L + G E T Sbjct: 207 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLNK 266 Query: 234 --PDYKPSFPKWARQDFSKVVPP-------LDEDGRSLLSQMLHYDPNKRISAKAALAHP 284 D +P + D+ PP + + +++ L +P +R K + H Sbjct: 267 FGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 326 Query: 285 FFQ 287 F + Sbjct: 327 FIK 329 >4YHJ-A nrPDB Length = 584 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 72/294 (24%), Positives = 128/294 (43%), Gaps = 34/294 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGV-PSTAIREISLLKELNHPN 62 F+ +G+G +G V + + TG++ A KK++ + + A+ E +L+++ Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRF 246 Query: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +V L T++ L LV ++ DLK + G Y +L GL Sbjct: 247 VVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRE 306 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 R+++RDLKP+N+L++ G I+++D GLA R V T+ Y APE++ K Y+ Sbjct: 307 RIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQR-VRGRVGTVGYMAPEVVNNEK-YT 364 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 + D W LGC+ EM+ + F E + + + + Sbjct: 365 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRI---------------------- 402 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDVT 290 + D + ED +S+ +L +P+KR+ A HP F+D+ Sbjct: 403 ---KNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDIN 453 >3HMP-A nrPDB Length = 342 Score = 216 bits (552), Expect = 6e-57, Method: Composition-based stats. Identities = 79/307 (25%), Positives = 129/307 (42%), Gaps = 44/307 (14%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN--HP 61 + +++IG G V++ N ++ A+K + L+ + EI+ L +L Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 I++L D T+ +Y+V E + DL ++ I KSY +L+ + H H Sbjct: 117 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKK--SIDPWERKSYWKNMLEAVHTIHQH 174 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT--YTHEVVTLWYRAPEILLGCK- 178 ++H DLKP N LI +G +KL DFG+A + +V T+ Y PE + Sbjct: 175 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 233 Query: 179 ---------YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 S D+WSLGCI M + F I+Q+ ++ + Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF--QQIINQISKLHAII---------- 281 Query: 230 VTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 P+++ FP +D + +L L DP +RIS LAHP+ Q Sbjct: 282 ---DPNHEIEFPDIPEKDL-----------QDVLKCCLKRDPKQRISIPELLAHPYVQIQ 327 Query: 290 TKPVPHL 296 T PV + Sbjct: 328 THPVNQM 334 >2R2P-A nrPDB Length = 295 Score = 216 bits (552), Expect = 6e-57, Method: Composition-based stats. Identities = 64/276 (23%), Positives = 123/276 (44%), Gaps = 19/276 (6%) Query: 5 QKVEKIGEGTYGVVYKARNKLTGEV---VALKKIRLDTETEGVPSTAIREISLLKELNHP 61 IG G +G V R KL G+ VA+K +++ TE + E S++ + +HP Sbjct: 25 TIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY-TEKQRRDFLGEASIMGQFDHP 83 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NI+ L V+ + +V E++ L F+ + + + L + G+ + Sbjct: 84 NIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQ-FTVIQLVGMLRGISAGMKYLSD 142 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVV--TLWYRAPEILLGC 177 +HRDL +N+LIN+ K++DFGL+R P YT + + APE + Sbjct: 143 MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-AF 201 Query: 178 KYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 + +++A D+WS G + E+V+ + + D + + P + P Y Sbjct: 202 RKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAAL----Y 257 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPN 272 + W ++ S+ P ++ ++L +++ +P Sbjct: 258 QLMLDCWQKERNSR---PKFDEIVNMLDKLI-RNPA 289 >5SYS-A nrPDB Length = 286 Score = 216 bits (552), Expect = 7e-57, Method: Composition-based stats. Identities = 70/291 (24%), Positives = 120/291 (41%), Gaps = 39/291 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E+ + K+G+G +G + T VA+K ++ T + P ++E ++K+L H Sbjct: 18 ESLRLEVKLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHE 73 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +V+L V+ +E +Y+V E++ L F+ + LP + Q+ G+A+ Sbjct: 74 KLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVER 132 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT-YTHEVVTLWYRAPEILLGCKY 179 +HRDL+ N+L+ K+ADFGLAR T + + APE L Sbjct: 133 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-YGR 191 Query: 180 YSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 ++ D+WS G + E+ T R +PG + L ++ R P P Sbjct: 192 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP---------- 241 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 E L+ Q DP +R + + A F +D Sbjct: 242 ------------------ESLHDLMCQCWRKDPEERPTFEYLQA--FLEDY 272 >6HMD-A nrPDB Length = 365 Score = 216 bits (551), Expect = 9e-57, Method: Composition-based stats. Identities = 89/307 (28%), Positives = 153/307 (49%), Gaps = 23/307 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH- 60 +++Q V K+G G Y V++A N E ++ + RE+ +L+ L Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPVKKKKIKREVKILENLRGG 107 Query: 61 PNIVKLLDVIHTE--NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 NI+KL+D + LVFE+++ K + I+ Y+++LL+ L +C Sbjct: 108 TNIIKLIDTVKDPVSKTPALVFEYINNTDFK----QLYQILTDFDIRFYMYELLKALDYC 163 Query: 119 HSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 HS ++HRD+KP N++I+ + ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 164 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDY 222 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRAL-FPGDSEIDQLFRIFRTLGTPD--------EVVWP 228 + Y ++D+WSLGC+ A M+ RR F G DQL RI + LGT + + Sbjct: 223 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 282 Query: 229 GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + + S +W S+ + + LL ++L YD +R++AK A+ HP+F Sbjct: 283 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 342 Query: 289 VTKPVPH 295 V K Sbjct: 343 VVKEQSQ 349 >5UUU-A nrPDB Length = 547 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 131/307 (42%), Gaps = 40/307 (13%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKEL- 58 M +F IG G +G VY R TG++ A+K + + + + + A+ E +L + Sbjct: 197 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 256 Query: 59 --NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 + P IV + HT +KL + + ++ DL + + ++ Y +++ GL Sbjct: 257 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEIILGL 314 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 H+ V++RDLKP N+L++ G ++++D GLA F + V T Y APE+L Sbjct: 315 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK--KKPHASVGTHGYMAPEVLQ 372 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 Y ++ D +SLGC+ +++ + F D Sbjct: 373 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD------------------------- 407 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDVT 290 K + ++ + RSLL +L D N+R+ A+ PFF+ + Sbjct: 408 -KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 466 Query: 291 KPVPHLR 297 + L+ Sbjct: 467 WQMVFLQ 473 >1JPA-A nrPDB Length = 312 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 58/274 (21%), Positives = 115/274 (41%), Gaps = 22/274 (8%) Query: 5 QKVEKIGEGTYGVVYKARNKLTGEV---VALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + + IG G +G V KL G+ VA+K ++ TE + E S++ + +HP Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-TEKQRRDFLSEASIMGQFDHP 94 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 N++ L V+ + ++ EF+ L F+ + + + L + G+ + Sbjct: 95 NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQ-FTVIQLVGMLRGIAAGMKYLAD 153 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR--TYTHEVV---TLWYRAPEILL 175 +HRDL +N+L+N+ K++DFGL+R TYT + + + APE + Sbjct: 154 MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQ 213 Query: 176 GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWP------ 228 + +++A D+WS G + E+++ + + D + I + P + P Sbjct: 214 -YRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQL 272 Query: 229 ---GVTSMPDYKPSFPKWARQDFSKVVPPLDEDG 259 +++P F + + P Sbjct: 273 MLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKA 306 >6BXI-A nrPDB Length = 333 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 127/330 (38%), Gaps = 71/330 (21%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKELN 59 +E+F+ ++ IG G +G V + K TG V A+K +R E IR E +L E + Sbjct: 5 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 64 Query: 60 HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 +VK+ + LYL+ EFL D+ + + + Y+ + + + Sbjct: 65 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLL--MKKDTLTEEETQFYIAETVLAIDSI 122 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE---------------- 162 H +HRD+KP NLL++++G +KL+DFGL RT + Sbjct: 123 HQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMN 182 Query: 163 -------------------VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALF 203 V T Y APE+ + Y+ D WSLG I EM+ F Sbjct: 183 SKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-YNKLCDWWSLGVIMYEMLIGYPPF 241 Query: 204 PGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLL 263 ++ + ++ W + P P + E + L+ Sbjct: 242 CSETPQETYKKVMN---------WKETLTFPPEVP----------------ISEKAKDLI 276 Query: 264 SQ-MLHYDPNKRISA---KAALAHPFFQDV 289 + ++ RI A + ++ FF+ V Sbjct: 277 LRFCCEWEH--RIGAPGVEEIKSNSFFEGV 304 >3DKO-A nrPDB Length = 318 Score = 215 bits (547), Expect = 2e-56, Method: Composition-based stats. Identities = 64/275 (23%), Positives = 119/275 (43%), Gaps = 17/275 (6%) Query: 5 QKVEKIGEGTYGVVYKARNKLTGEV---VALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + IG G +G V R KL G+ VA+K +++ TE + E S++ + +HP Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY-TEKQRRDFLCEASIMGQFDHP 104 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 N+V L V+ + +V EF+ + + L + G+ + Sbjct: 105 NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADM 164 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP---VRTYTHEVVTLWYRAPEILLGCK 178 +HRDL +N+L+N+ K++DFGL+R V T T + + + APE + + Sbjct: 165 GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQ-YR 223 Query: 179 YYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 +++A D+WS G + E+++ + S D + I P + P ++ Sbjct: 224 KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPA----GLHQ 279 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPN 272 W ++ + P E +L +M+ +PN Sbjct: 280 LMLDCWQKE---RAERPKFEQIVGILDKMI-RNPN 310 >4AN9-A nrPDB Length = 301 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 75/288 (26%), Positives = 132/288 (45%), Gaps = 35/288 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++F+K+ ++G G GVV+K +K +G V+A K I L+ + + + IRE+ +L E N P Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 67 Query: 62 NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC-H 119 IV +++ ++ + E + L + + + IP ++ +++GL + Sbjct: 68 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLRE 125 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 H+++HRD+KP N+L+N+ G IKL DFG++ V T Y +PE L G + Sbjct: 126 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDEMANEFVGTRSYMSPERLQGT-H 182 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 YS DIWS+G EM R P + + L D +V +P S Sbjct: 183 YSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELL----------DYIVNEPPPKLPSAVFS 232 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 + + +++ L +P +R K + H F + Sbjct: 233 L-----------------EFQDFVNKCLIKNPAERADLKQLMVHAFIK 263 >3PVW-A nrPDB Length = 695 Score = 214 bits (546), Expect = 3e-56, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 131/307 (42%), Gaps = 40/307 (13%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKEL- 58 M +F IG G +G VY R TG++ A+K + + + + + A+ E +L + Sbjct: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 Query: 59 --NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 + P IV + HT +KL + + ++ DL + + ++ Y +++ GL Sbjct: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEIILGL 305 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 H+ V++RDLKP N+L++ G ++++D GLA F + V T Y APE+L Sbjct: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK--KKPHASVGTHGYMAPEVLQ 363 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 Y ++ D +SLGC+ +++ + F D Sbjct: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD------------------------- 398 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDVT 290 K + ++ + RSLL +L D N+R+ A+ PFF+ + Sbjct: 399 -KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 Query: 291 KPVPHLR 297 + L+ Sbjct: 458 WQMVFLQ 464 >2ZMD-A nrPDB Length = 390 Score = 214 bits (546), Expect = 3e-56, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 128/307 (41%), Gaps = 44/307 (14%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN--HP 61 + +++IG G V++ N ++ A+K + L+ + EI+ L +L Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 I++L D T+ +Y+V E + DL ++ I KSY +L+ + H H Sbjct: 117 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKK--SIDPWERKSYWKNMLEAVHTIHQH 174 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT--YTHEVVTLWYRAPEILLGCK- 178 ++H DLKP N LI +G +KL DFG+A + +V + Y PE + Sbjct: 175 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSS 233 Query: 179 ---------YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 S D+WSLGCI M + F I+Q+ ++ + Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF--QQIINQISKLHAII---------- 281 Query: 230 VTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 P+++ FP +D + +L L DP +RIS LAHP+ Q Sbjct: 282 ---DPNHEIEFPDIPEKDL-----------QDVLKCCLKRDPKQRISIPELLAHPYVQIQ 327 Query: 290 TKPVPHL 296 T PV + Sbjct: 328 THPVNQM 334 >4OTD-A nrPDB Length = 341 Score = 214 bits (546), Expect = 3e-56, Method: Composition-based stats. Identities = 77/299 (25%), Positives = 130/299 (43%), Gaps = 43/299 (14%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL-DTETEGVPSTAIREISLLKEL- 58 +E+F+ + +G G +G V + + +GE+ A+K ++ D + + E +L + Sbjct: 11 LEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVT 70 Query: 59 --NHPNIVKLLDVIHTENKLYLVFEF-LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 HP +V L T + V E+ DL + + P Y ++ GL Sbjct: 71 SAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDV---FSEPRAIFYSACVVLGL 127 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 F H H++++RDLK NLL++TEG +K+ADFGL + + T + APE+L Sbjct: 128 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 187 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 Y+ AVD W LG + EM+ + FPGD E + I DEV +P Sbjct: 188 DTS-YTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN-----DEVRYPRF----- 236 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFFQDV 289 L + ++ ++L +P +R+ A+ PFF+ + Sbjct: 237 -------------------LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTL 276 >5X5O-A nrPDB Length = 310 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 66/283 (23%), Positives = 120/283 (42%), Gaps = 44/283 (15%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++ Q E G G++G VY+A+ + VA+KK+ +E +L L+H Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK----------IEKEAEILSVLSHR 64 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NI++ VI +V E+ L +++++ + + I ++ + +G+ + H Sbjct: 65 NIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHM 124 Query: 121 H---RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 +V+HRDLK +N++I +G +K+ DFG +R T+ V T + APE++ Sbjct: 125 EAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHT--THMSLVGTFPWMAPEVIQSL 182 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 S D +S G + EM+TR F G + + + + + Sbjct: 183 PV-SETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVE----------------KNER 225 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA 280 + P + F++ LL Q D KR S K Sbjct: 226 LTIPSSCPRSFAE-----------LLHQCWEADAKKRPSFKQI 257 >2Y6O-A nrPDB Length = 291 Score = 214 bits (545), Expect = 4e-56, Method: Composition-based stats. Identities = 61/280 (21%), Positives = 125/280 (44%), Gaps = 21/280 (7%) Query: 5 QKVEKIGEGTYGVVYKARNKLTGEV---VALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + + IG G +G V R K+ G+ VA+K ++ T+ + E S++ + +HP Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGY-TDKQRRDFLSEASIMGQFDHP 75 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NI+ L V+ + ++ E++ L F+ + + + L + G+ + Sbjct: 76 NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGR-FTVIQLVGMLRGIGSGMKYLSD 134 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVV--TLWYRAPEILLGC 177 +HRDL +N+L+N+ K++DFG++R P YT + + APE + Sbjct: 135 MSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-AY 193 Query: 178 KYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 + +++A D+WS G + E+++ + S D + I P + P + + Sbjct: 194 RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCP----IALH 249 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPN--KR 274 + W ++ + P ++L +++ +PN KR Sbjct: 250 QLMLDCWQKERSDR---PKFGQIVNMLDKLI-RNPNSLKR 285 >3RAW-A nrPDB Length = 381 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 85/332 (25%), Positives = 143/332 (43%), Gaps = 48/332 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGE-VVALKKIRLDTETEGVPSTAIREISLLKEL-- 58 E ++ V +GEGT+G V + + G+ VALK IR + A EI++LK++ Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGK---YREAARLEINVLKKIKE 107 Query: 59 -NHPN---IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 + N V + D + + + FE L ++ +F+ + PLP ++ +QL Sbjct: 108 KDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHA 167 Query: 115 LAFCHSHRVLHRDLKPQNLLINT-------------------EGAIKLADFGLARAFGVP 155 L F H +++ H DLKP+N+L +I++ADFG A Sbjct: 168 LRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF---D 224 Query: 156 VRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRI 215 +T V T YR PE++L ++ D+WS+GCI E LF + L + Sbjct: 225 HEHHTTIVATRHYRPPEVILELG-WAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMM 283 Query: 216 FRTLGTPDEVVWPGVTSMP---------DYKPSFPKWARQDFSKVVPPLDEDGR------ 260 + LG + D S ++ +++ + + +D Sbjct: 284 EKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLF 343 Query: 261 SLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 L+ +ML +DP +RI+ AL HPFF +T Sbjct: 344 DLMRRMLEFDPAQRITLAEALLHPFFAGLTPE 375 >5AP3-A nrPDB Length = 313 Score = 213 bits (544), Expect = 5e-56, Method: Composition-based stats. Identities = 79/307 (25%), Positives = 129/307 (42%), Gaps = 44/307 (14%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN--HP 61 + +++IG G V++ N ++ A+K + L+ + EI+ L +L Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 I++L D T+ +Y+V E + DL ++ I KSY +L+ + H H Sbjct: 89 KIIRLYDYEITDQYIYMVMECGNIDLNGWLKKKK--SIDPWERKSYWKNMLEAVHTIHQH 146 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT--YTHEVVTLWYRAPEILLGCK- 178 ++H DLKP N LI +G +KL DFG+A + +V T+ Y PE + Sbjct: 147 GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 205 Query: 179 ---------YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 S D+WSLGCI M + F I+Q+ ++ + Sbjct: 206 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAII---------- 253 Query: 230 VTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 P+++ FP +D + +L L DP +RIS LAHP+ Q Sbjct: 254 ---DPNHEIEFPDIPEKDL-----------QDVLKCCLKRDPKQRISIPELLAHPYVQIQ 299 Query: 290 TKPVPHL 296 T PV + Sbjct: 300 THPVNQM 306 >5XVU-A nrPDB Length = 332 Score = 213 bits (543), Expect = 6e-56, Method: Composition-based stats. Identities = 92/305 (30%), Positives = 155/305 (50%), Gaps = 25/305 (8%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH- 60 ++ ++KIG G Y V+ + A + REI +L+ LN Sbjct: 31 NRYEIMKKIGRGKYSEVFNGYDTECNRPCA-----IKVLKPVKKKKIKREIKILQNLNGG 85 Query: 61 PNIVKLLDVIHTE--NKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 PNI+KLLD++ L+FE+++ D K I+ Y++Q+L+ L + Sbjct: 86 PNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTL-----YPKFTDKDIRYYIYQILKALDY 140 Query: 118 CHSHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 CHS ++HRD+KP N++I+ E I+L +GLA F P + Y V + +Y+ PE+L+ Sbjct: 141 CHSQGIMHRDVKPHNIMIDHENRQIRLISWGLA-EFYHPGQEYNVRVASRYYKGPELLID 199 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRAL-FPGDSEIDQLFRIFRTLGTPDEVVW---PGVTS 232 + Y ++DIWSLGC+ A M+ ++ F G DQL +I + LGT D + + Sbjct: 200 LQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKL 259 Query: 233 MPDYKPSFPKWARQDFSKVVPPLD-----EDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 P Y ++ R+ +S + + ++ L+ +ML YD KRI+ K A+ HP+F+ Sbjct: 260 KPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEHPYFR 319 Query: 288 DVTKP 292 +V + Sbjct: 320 EVREE 324 >4GS6-A nrPDB Length = 315 Score = 213 bits (542), Expect = 8e-56, Method: Composition-based stats. Identities = 83/287 (28%), Positives = 125/287 (43%), Gaps = 44/287 (15%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + + E +G G +GVV KA+ + + VA+K+I E+E I E+ L +NHP Sbjct: 9 KEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQI----ESESERKAFIVELRQLSRVNHP 62 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMD-ASALTGIPLPLIKSYLFQLLQGLAFCH 119 NIVKL N + LV E+ L + A L S+ Q QG+A+ H Sbjct: 63 NIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH 120 Query: 120 SHR---VLHRDLKPQNLLINTEGAI-KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 S + ++HRDLKP NLL+ G + K+ DFG A T+ + + APE+ Sbjct: 121 SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ---THMTNNKGSAAWMAPEVFE 177 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 G YS D++S G I E++TRR F +G P + V Sbjct: 178 GS-NYSEKCDVFSWGIILWEVITRRKPF-------------DEIGGPAFRIMWAV----- 218 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 282 R K +P E SL+++ DP++R S + + Sbjct: 219 -----HNGTRPPLIKNLPKPIE---SLMTRCWSKDPSQRPSMEEIVK 257 >4EBW-A nrPDB Length = 304 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 68/287 (23%), Positives = 125/287 (43%), Gaps = 38/287 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEV---VALKKIRLDTETEGVPSTAIREISLLKEL 58 E + IGEG +G V++ VA+K + + ++ V ++E +++ Sbjct: 38 ERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK-NCTSDSVREKFLQEALTMRQF 96 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 +HP+IVKL+ VI TEN ++++ E +L+ F+ + + L + Y +QL LA+ Sbjct: 97 DHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKYS-LDLASLILYAYQLSTALAY 154 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV-PVRTYTHEVVTLWYRAPEILLG 176 S R +HRD+ +N+L+++ +KL DFGL+R + + + + APE + Sbjct: 155 LESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESI-N 213 Query: 177 CKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 + +++A D+W G E++ F G D + RI P Sbjct: 214 FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLP------------- 260 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 282 + P SL+++ YDP++R A Sbjct: 261 ---------------MPPNCPPTLYSLMTKCWAYDPSRRPRFTELKA 292 >6EII-A nrPDB Length = 352 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 89/303 (29%), Positives = 151/303 (49%), Gaps = 23/303 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH- 60 +++Q V K+G G Y V++A N E + + REI +L+ L Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKKKIKREIKILENLRGG 114 Query: 61 PNIVKLLDVIHTE--NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 PNI+ L D++ LVFE ++ K + I+ Y++++L+ L +C Sbjct: 115 PNIITLADIVKDPVSRTPALVFEHVNNTDFK----QLYQTLTDYDIRFYMYEILKALDYC 170 Query: 119 HSHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 HS ++HRD+KP N++I+ E ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 171 HSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVDY 229 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRAL-FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 + Y ++D+WSLGC+ A M+ R+ F G DQL RI + LGT D + ++ Sbjct: 230 QMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELD 289 Query: 237 --------KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + S +W R S+ + + L ++L YD R++A+ A+ HP+F Sbjct: 290 PRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 349 Query: 289 VTK 291 V K Sbjct: 350 VVK 352 >2HK5-A nrPDB Length = 270 Score = 211 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 71/254 (27%), Positives = 128/254 (50%), Gaps = 24/254 (9%) Query: 2 ENFQKVEKIGEGTYGVVYKA-RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 E+ + +K+G G +G V+ A NK T VA+K ++ + + + E +++K L H Sbjct: 15 ESLKLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSMS---VEAFLAEANVMKTLQH 69 Query: 61 PNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 +VKL V+ T+ +Y++ EF+ L F+ + + PLP + + Q+ +G+AF Sbjct: 70 DKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIE 128 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV---TLWYRAPEILLG 176 +HRDL+ N+L++ K+ADFGLAR YT + + APE + Sbjct: 129 QRNYIHRDLRAANILVSASLVCKIADFGLARVIED--NEYTAREGAKFPIKWTAPEAI-N 185 Query: 177 CKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSE------IDQLFRIFRTLGTPDE---VV 226 ++ D+WS G + E+VT R +PG S +++ +R+ R P+E ++ Sbjct: 186 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIM 245 Query: 227 WPGVTSMPDYKPSF 240 + P+ +P+F Sbjct: 246 MRCWKNRPEERPTF 259 >2PL0-A nrPDB Length = 289 Score = 211 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 64/253 (25%), Positives = 123/253 (48%), Gaps = 22/253 (8%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E + VE++G G +G V+ VA+K ++ + + P + E +L+K+L H Sbjct: 23 ETLKLVERLGAGQFGEVWMGYYNGH-TKVAVKSLKQGSMS---PDAFLAEANLMKQLQHQ 78 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 +V+L V+ T+ +Y++ E++ L F+ + + + + Q+ +G+AF Sbjct: 79 RLVRLYAVV-TQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEE 137 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV---TLWYRAPEILLGC 177 +HRDL+ N+L++ + K+ADFGLAR YT + + APE + Sbjct: 138 RNYIHRDLRAANILVSDTLSCKIADFGLARLIED--NEYTAREGAKFPIKWTAPEAI-NY 194 Query: 178 KYYSTAVDIWSLGCIFAEMVT-RRALFPGDS------EIDQLFRIFRTLGTPDE---VVW 227 ++ D+WS G + E+VT R +PG + +++ +R+ R P+E ++ Sbjct: 195 GTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMR 254 Query: 228 PGVTSMPDYKPSF 240 P+ +P+F Sbjct: 255 LCWKERPEDRPTF 267 >5A46-A nrPDB Length = 386 Score = 211 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 69/307 (22%), Positives = 137/307 (44%), Gaps = 39/307 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGE-------VVALKKIRLDTETEGVPSTAIREISL 54 + + +GEG +G V A + VA+K ++ D TE S I E+ + Sbjct: 40 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA-TEKDLSDLISEMEM 98 Query: 55 LKEL-NHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPL--------- 103 +K + H NI+ LL + LY++ E+ +L++++ A G+ Sbjct: 99 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 158 Query: 104 -----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG--VPV 156 + S +Q+ +G+ + S + +HRDL +N+L+ + +K+ADFGLAR Sbjct: 159 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 218 Query: 157 RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRI 215 + T+ + + + APE L + Y+ D+WS G + E+ T + +PG +++LF++ Sbjct: 219 KKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKL 276 Query: 216 FRTLGTPDE----------VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQ 265 + D+ ++ ++P +P+F + V +++ L Sbjct: 277 LKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMP 336 Query: 266 MLHYDPN 272 + Y P+ Sbjct: 337 LDQYSPS 343 >2VWV-A nrPDB Length = 302 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 60/278 (21%), Positives = 116/278 (41%), Gaps = 21/278 (7%) Query: 5 QKVEKIGEGTYGVVYKARNKLTGEV---VALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + E IG G +G V + R K G+ VA+K ++ TE + E S++ + HP Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK-GGYTERQRREFLSEASIMGQFEHP 77 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NI++L V+ + ++ EF+ L F+ + + + L + G+ + Sbjct: 78 NIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQ-FTVIQLVGMLRGIASGMRYLAE 136 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE-----VVTLWYRAPEILL 175 +HRDL +N+L+N+ K++DFGL+R T + + + APE + Sbjct: 137 MSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAI- 195 Query: 176 GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 + +++A D WS G + E+++ + S D + I + P P Sbjct: 196 AFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSL--- 252 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPN 272 ++ W + ++ P +M+ +P Sbjct: 253 -HQLMLDCWQKDRNARPRFPQVVSALD---KMI-RNPA 285 >4YFF-A nrPDB Length = 311 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 58/258 (22%), Positives = 113/258 (43%), Gaps = 19/258 (7%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTE-TEGVPSTAIREISLLKELN 59 + + E IG G++G VYK R + ++VA+K+ R +T ++ RE+S+L +LN Sbjct: 41 LSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 98 Query: 60 HPNIVKLLDVIHTENKLY-LVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 HP +++ + + + +V +++ L + + L + +G+ + Sbjct: 99 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDVAKGMEY 157 Query: 118 CHS--HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV-PVRTYTHEVVTLWYRAPEIL 174 H+ ++HRDL N+L+ +G +ADFG +R T + L + APE+ Sbjct: 158 LHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVF 217 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALF----PGDSEIDQLFRIFR------TLGTPDE 224 C Y+ D++S E++T F P + D + R Sbjct: 218 TQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISS 277 Query: 225 VVWPGVTSMPDYKPSFPK 242 ++ G + P+ +P F + Sbjct: 278 LLIRGWNACPEGRPEFSE 295 >1S9I-A nrPDB Length = 354 Score = 210 bits (534), Expect = 7e-55, Method: Composition-based stats. Identities = 81/308 (26%), Positives = 138/308 (44%), Gaps = 29/308 (9%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++F+++ ++G G GVV K +++ +G ++A K I L+ + + + IRE+ +L E N P Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 74 Query: 62 NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC-H 119 IV +++ ++ + E + L + + IP ++ +L+GLA+ Sbjct: 75 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKE--AKRIPEEILGKVSIAVLRGLAYLRE 132 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 H+++HRD+KP N+L+N+ G IKL DFG++ V T Y APE L G + Sbjct: 133 KHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMAPERLQGT-H 189 Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM------ 233 YS DIWS+G E+ R P + L IF E P S Sbjct: 190 YSVQSDIWSMGLSLVELAVGRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHSISPRPRPPG 248 Query: 234 -------PDYKPSFPKWARQDFSKVVPP-------LDEDGRSLLSQMLHYDPNKRISAKA 279 D +P+ + D+ PP D + +++ L +P +R K Sbjct: 249 RPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKM 308 Query: 280 ALAHPFFQ 287 H F + Sbjct: 309 LTNHTFIK 316 >4UYA-A nrPDB Length = 340 Score = 210 bits (534), Expect = 8e-55, Method: Composition-based stats. Identities = 76/278 (27%), Positives = 115/278 (41%), Gaps = 29/278 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE--GVPSTAIREISLLKELN 59 E + E IG G +G VY+A G+ VA+K R D E + + RE L L Sbjct: 26 ERLELKELIGAGGFGQVYRAT--WQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLR 83 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 HPNI++L V + L LV EF A A IP ++ ++ Q+ +G+ + H Sbjct: 84 HPNIIELRGVCLQQPHLCLVLEFARGGALN--RALAGRRIPPHVLVNWAVQIARGMLYLH 141 Query: 120 SHR---VLHRDLKPQNLLINT--------EGAIKLADFGLARAFGVPVRTYTHEVVTLWY 168 +LHRDLK N+L+ +K+ DFGLAR + + T + Sbjct: 142 EEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATA--GAYAW 199 Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228 APE++ +S DIWS G + E++T + G ID L + + P Sbjct: 200 MAPEVIKSS-LFSKGSDIWSYGVLLWELLTGEVPYRG---IDGLAVAYGVAVNKLTLPIP 255 Query: 229 GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQM 266 P K W + P + +L Q+ Sbjct: 256 STCPEPFAKLMKECWQQD------PHIRPSFALILEQL 287 >2J0K-A nrPDB Length = 656 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 68/287 (23%), Positives = 124/287 (43%), Gaps = 38/287 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTG---EVVALKKIRLDTETEGVPSTAIREISLLKEL 58 E + IGEG +G V++ VA+K + + ++ V ++E +++ Sbjct: 390 ERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCK-NCTSDSVREKFLQEALTMRQF 448 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 +HP+IVKL+ VI TEN ++++ E +L+ F+ + + L + Y +QL LA+ Sbjct: 449 DHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKFS-LDLASLILYAYQLSTALAY 506 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILLG 176 S R +HRD+ +N+L++ +KL DFGL+R + + + + APE + Sbjct: 507 LESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESI-N 565 Query: 177 CKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 + +++A D+W G E++ F G D + RI P Sbjct: 566 FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLP------------- 612 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 282 + P SL+++ YDP++R A Sbjct: 613 ---------------MPPNCPPTLYSLMTKCWAYDPSRRPRFTELKA 644 >3GQL-A nrPDB Length = 326 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 133/297 (44%), Gaps = 39/297 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGE-------VVALKKIRLDTETEGVPSTAIREISL 54 + + +GEG +G V A + VA+K ++ D TE S I E+ + Sbjct: 28 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA-TEKDLSDLISEMEM 86 Query: 55 LKEL-NHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPL--------- 103 +K + H NI+ LL + LY++ E+ +L++++ A G+ Sbjct: 87 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 146 Query: 104 -----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG--VPV 156 + S +Q+ +G+ + S + +HRDL +N+L+ + +K+ADFGLAR Sbjct: 147 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 206 Query: 157 RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRI 215 + T+ + + + APE L + Y+ D+WS G + E+ T + +PG +++LF++ Sbjct: 207 KKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKL 264 Query: 216 FRTLGTPDE----------VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSL 262 + D+ ++ ++P +P+F + V +++ L Sbjct: 265 LKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDL 321 >4EQM-A nrPDB Length = 294 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 64/219 (29%), Positives = 114/219 (52%), Gaps = 6/219 (2%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKELNH 60 E ++ V+K+G G VY A + + VA+K I + E E RE+ +L+H Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSH 70 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 NIV ++DV ++ YLV E++ L +++++ + + ++ Q+L G+ H Sbjct: 71 QNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGP--LSVDTAINFTNQILDGIKHAH 128 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV-VTLWYRAPEILLGCK 178 R++HRD+KPQN+LI++ +K+ DFG+A+A T T+ V T+ Y +PE G Sbjct: 129 DMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGEA 188 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR 217 DI+S+G + EM+ F G++ + + + Sbjct: 189 T-DECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQ 226 >4AT3-A nrPDB Length = 299 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 62/265 (23%), Positives = 111/265 (41%), Gaps = 27/265 (10%) Query: 3 NFQKVEKIGEGTYGVVYKARN-----KLTGEVVALKKIRLDTETEGVPSTAIREISLLKE 57 N ++GEG +G V+ A + +VA+K ++ ++ RE LL Sbjct: 14 NIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK--DASDNARKDFHREAELLTN 71 Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASAL-----------TGIPLPLIK 105 L H +IVK V + L +VFE++ H DL KF+ A T + + Sbjct: 72 LQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQML 131 Query: 106 SYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYTHEV 163 Q+ G+ + S +HRDL +N L+ +K+ DFG++R R H + Sbjct: 132 HIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTM 191 Query: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTP 222 + + + PE ++ + ++T D+WSLG + E+ T + + S + + + Sbjct: 192 LPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNE----VIECITQG 246 Query: 223 DEVVWPGVTSMPDYKPSFPKWARQD 247 + P Y+ W R+ Sbjct: 247 RVLQRPRTCPQEVYELMLGCWQREP 271 >1AD5-A nrPDB Length = 438 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 69/251 (27%), Positives = 126/251 (50%), Gaps = 28/251 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKA-RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 E+ + +K+G G +G V+ A NK T VA+K ++ + + + E +++K L H Sbjct: 182 ESLKLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSMS---VEAFLAEANVMKTLQH 236 Query: 61 PNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 +VKL V+ T+ +Y++ EF+ L F+ + + PLP + + Q+ +G+AF Sbjct: 237 DKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIE 295 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179 +HRDL+ N+L++ K+ADFGLAR + + APE + Sbjct: 296 QRNYIHRDLRAANILVSASLVCKIADFGLARV---------GAKFPIKWTAPEAI-NFGS 345 Query: 180 YSTAVDIWSLGCIFAEMVT-RRALFPGDSE------IDQLFRIFRTLGTPDE---VVWPG 229 ++ D+WS G + E+VT R +PG S +++ +R+ R P+E ++ Sbjct: 346 FTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRC 405 Query: 230 VTSMPDYKPSF 240 + P+ +P+F Sbjct: 406 WKNRPEERPTF 416 >6FER-A nrPDB Length = 309 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 71/294 (24%), Positives = 121/294 (41%), Gaps = 36/294 (12%) Query: 4 FQKVEKIGEGTYGVVYKAR--------------NKLTGE--VVALKKIRLDTETEGVPST 47 EK+GEG +G V+ + + +VA+K +R D + + Sbjct: 11 LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADA-NKNARND 69 Query: 48 AIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASAL--------TG 98 ++EI ++ L PNI+ LL V T++ L ++ E++ DL +F+ Sbjct: 70 FLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRT 129 Query: 99 IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPV 156 + +K Q+ G+ + S +HRDL +N L+ IK+ADFG++R G Sbjct: 130 VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYY 189 Query: 157 RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT--RRALF---PGDSEIDQ 211 R V+ + + + E +L ++TA D+W+ G E T + + + I+ Sbjct: 190 RIQGRAVLPIRWMSWESIL-LGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIEN 248 Query: 212 LFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQ 265 FR G + P + YK W R +K P E LL Q Sbjct: 249 TGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRD--TKNRPSFQEIHLLLLQQ 300 >1TKI-A nrPDB Length = 321 Score = 208 bits (530), Expect = 2e-54, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 128/296 (43%), Gaps = 34/296 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E + E +G G +G+V++ + + K +++ + + +EIS+L H Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVL---VKKEISILNIARHR 61 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NI+ L + + +L ++FEF+ D+ + ++ SA + I SY+ Q+ + L F HS Sbjct: 62 NILHLHESFESMEELVMIFEFISGLDIFERINTSAFE-LNEREIVSYVHQVCEALQFLHS 120 Query: 121 HRVLHRDLKPQNLLINTE--GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 H + H D++P+N++ T IK+ +FG AR P + Y APE+ Sbjct: 121 HNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLK-PGDNFRLLFTAPEYYAPEV-HQHD 178 Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238 STA D+WSLG + +++ F ++ + I T DE + Sbjct: 179 VVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFK---------- 228 Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294 + + + ++L + R++A AL HP+ + + V Sbjct: 229 ---------------EISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQKIERVS 269 >3V5Q-A nrPDB Length = 297 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 115/301 (38%), Gaps = 54/301 (17%) Query: 3 NFQKVEKIGEGTYGVVYKARN-----KLTGEVVALKKIRLDTETEGVPSTAIREISLLKE 57 + ++GEG +G V+ A +VA+K ++ T RE LL Sbjct: 16 DIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTL--AARKDFQREAELLTN 73 Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALT--------------GIPLP 102 L H +IVK V + L +VFE++ H DL KF+ A + L Sbjct: 74 LQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLS 133 Query: 103 LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYT 160 + Q+ G+ + S +HRDL +N L+ +K+ DFG++R R Sbjct: 134 QMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGG 193 Query: 161 HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTL 219 H ++ + + PE ++ + ++T D+WS G I E+ T + + S + + I + Sbjct: 194 HTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGR 252 Query: 220 GTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKA 279 V P ++ ++ +P +R++ K Sbjct: 253 VLERPRVCP----------------------------KEVYDVMLGCWQREPQQRLNIKE 284 Query: 280 A 280 Sbjct: 285 I 285 >3TT0-A nrPDB Length = 382 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 66/293 (22%), Positives = 132/293 (45%), Gaps = 39/293 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGE-------VVALKKIRLDTETEGVPSTAIREISL 54 + + +GEG +G V A + VA+K ++ D TE S I E+ + Sbjct: 69 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA-TEKDLSDLISEMEM 127 Query: 55 LKEL-NHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPL--------- 103 +K + H NI+ LL + LY++ E+ +L++++ A G+ Sbjct: 128 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQ 187 Query: 104 -----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG--VPV 156 + S +Q+ +G+ + S + +HRDL +N+L+ + +K+ADFGLAR Sbjct: 188 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 247 Query: 157 RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRI 215 + T+ + + + APE L + Y+ D+WS G + E+ T + +PG +++LF++ Sbjct: 248 KKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPG-VPVEELFKL 305 Query: 216 FRTLGTPDE----------VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDED 258 + D+ ++ ++P +P+F + V +++ Sbjct: 306 LKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE 358 >4CRS-A nrPDB Length = 341 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 78/297 (26%), Positives = 128/297 (43%), Gaps = 43/297 (14%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL-DTETEGVPSTAIREISLLKELN 59 +++F+ + G +G V A K T E+ A+K ++ D + + E + + +N Sbjct: 11 LQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVN 70 Query: 60 ---HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 HP +V L T+ + V E+ DL + P Y ++ GL Sbjct: 71 SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDV---FSEPRAVFYAACVVLGL 127 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 + H H++++RDLK NLL++TEG +K+ADFGL + + T + APE+L Sbjct: 128 QYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 187 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 Y+ AVD W LG + EM+ + FPGD E + I DEV +P Sbjct: 188 ETS-YTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN-----DEVRYPRF----- 236 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKA-----ALAHPFFQ 287 L + S++ ++L +P +R+ A HPFF+ Sbjct: 237 -------------------LSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFR 274 >1K9A-A nrPDB Length = 450 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 62/289 (21%), Positives = 116/289 (40%), Gaps = 44/289 (15%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 M+ + ++ IG+G +G V + G VA+K I+ D + E S++ +L H Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKND----ATAQAFLAEASVMTQLRH 245 Query: 61 PNIVKLLDVI-HTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 N+V+LL VI + LY+V E++ L ++ + + + + + + + + + Sbjct: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 305 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 + +HRDL +N+L++ + K++DFGL + T V + APE L K Sbjct: 306 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV---KWTAPEALRE-K 361 Query: 179 YYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 +ST D+WS G + E+ + R +P D + R+ + P Sbjct: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVY----- 416 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS---AKAALAH 283 ++ H D R + + L H Sbjct: 417 -----------------------DVMKNCWHLDAATRPTFLQLREQLEH 442 >6GQK-A nrPDB Length = 328 Score = 207 bits (527), Expect = 5e-54, Method: Composition-based stats. Identities = 65/318 (20%), Positives = 121/318 (38%), Gaps = 58/318 (18%) Query: 2 ENFQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETEGVPSTAIREISLLK 56 + +G G +G V +A + VA+K ++ + + E+ +L Sbjct: 41 NRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLK-PSAHSTEREALMSELKVLS 99 Query: 57 EL-NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIP-------------- 100 L NH NIV LL ++ E+ + DL F+ +P Sbjct: 100 YLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLT 159 Query: 101 LPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR--T 158 L + S+ +Q+ +G+AF S +HRDL +N+L+ K+ DFGLAR Sbjct: 160 LEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVD 219 Query: 159 YTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFR 217 + + + + APE + Y+ D+WS G E+ + + +PG + +++ + Sbjct: 220 KGNARLPVKWMAPESIFNS-VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIK 278 Query: 218 TLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA 277 ++ S P++A + ++ DP+KR + Sbjct: 279 ----------------EGFRMSSPEYAPA-----------EMYDIMKTCWDADPDKRPTF 311 Query: 278 KAALAHPFFQDVTKPVPH 295 K QD+ K + Sbjct: 312 KQI-----VQDIEKQISE 324 >4OLI-A nrPDB Length = 645 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 70/282 (24%), Positives = 122/282 (43%), Gaps = 26/282 (9%) Query: 4 FQKVEKIGEGTYGVV----YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 +K+ +GEG +G V Y N TGE+VA+K ++ D + S +EI +L+ L Sbjct: 355 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQ-HRSGWKQEIDILRTLY 413 Query: 60 HPNIVKLLDVIHTENK--LYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 H +I+K + + L LV E++ L D I L + + Q+ +G+A+ Sbjct: 414 HEHIIKYKGCCEDQGEKSLQLVMEYVP--LGSLRDYLPRHSIGLAQLLLFAQQICEGMAY 471 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV---VTLWYRAPEIL 174 HS +HR+L +N+L++ + +K+ DFGLA+A Y +++ APE L Sbjct: 472 LHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECL 531 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 K+Y A D+WS G E++T DS + +G + G ++ Sbjct: 532 KEYKFY-YASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELIG-----IAQGQMTVL 580 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS 276 + R P + L+ + + R + Sbjct: 581 RLTELLERGERLPRPDKCP---CEVYHLMKNCWETEASFRPT 619 Score = 109 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 55/270 (20%), Positives = 97/270 (35%), Gaps = 43/270 (15%) Query: 21 ARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF 80 R++ V LK + D + SL+ +++H ++ + V + +V Sbjct: 88 GRDRGQELRVVLKVL--DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVT 145 Query: 81 EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA 140 E++ +P+ QL L++ + ++H ++ +N+L+ G Sbjct: 146 EYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGL 205 Query: 141 -------IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL-LGCKYYSTAVDIWSLGCI 192 IKL+D G G+ + V + + APE L G STA+D W G Sbjct: 206 AEGTSPFIKLSDPG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGAT 261 Query: 193 FAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVV 252 E+ F G++ P + P K F + + Sbjct: 262 LLEIC-----FDGEA--------------------PLQSRSPSEKEHFYQRQHRLPEPSC 296 Query: 253 PPLDEDGRSLLSQMLHYDPNKRISAKAALA 282 P L L SQ L Y+P +R S + L Sbjct: 297 PQLAT----LTSQCLTYEPTQRPSFRTILR 322 >4XLV-A nrPDB Length = 328 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 65/312 (20%), Positives = 126/312 (40%), Gaps = 53/312 (16%) Query: 2 ENFQKVEKIGEGTYGVVYK--ARNKLTGE---VVALKKIRLDTETEGVPSTAIREISLLK 56 E + ++G+G++G+VY+ AR+ + GE VA+K + ++ + + E S++K Sbjct: 39 EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ESASLRERIEFLNEASVMK 97 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGI--------PLPLIKSY 107 ++V+LL V+ +V E + H DLK ++ + L + Sbjct: 98 GFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQM 157 Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--T 165 ++ G+A+ ++ + +HRDL +N ++ + +K+ DFG+ R Sbjct: 158 AAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLP 217 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTR-RALFPGDSEIDQLFRIFRTLGTPDE 224 + + APE L ++T+ D+WS G + E+ + + G S L + Sbjct: 218 VRWMAPESLKD-GVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDG------ 270 Query: 225 VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA-- 282 G PD P E L+ ++PN R + + Sbjct: 271 ----GYLDQPDNCP------------------ERVTDLMRMCWQFNPNMRPTFLEIVNLL 308 Query: 283 ----HPFFQDVT 290 HP F +V+ Sbjct: 309 KDDLHPSFPEVS 320 >4KIK-B nrPDB Length = 677 Score = 206 bits (526), Expect = 7e-54, Method: Composition-based stats. Identities = 77/284 (27%), Positives = 126/284 (44%), Gaps = 19/284 (6%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 ++ E++G G +G V + N+ TGE +A+K+ R + + EI +++ L HPN+ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL-EIQIMRRLTHPNV 79 Query: 64 VKLLDVIHTENKL------YLVFEFL-HQDLKKFMDA-SALTGIPLPLIKSYLFQLLQGL 115 V DV L L E+ DL+K+++ G+ I + L + L Sbjct: 80 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASAL 139 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGA---IKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 + H +R++HRDLKP+N+++ K+ D G A+ T V TL Y APE Sbjct: 140 RYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLC-TSFVGTLQYLAPE 198 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 +L K Y+ VD WS G + E +T F + + Q R D VV + Sbjct: 199 LLEQQK-YTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNG 257 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS 276 + S P + S + L++ L ML + P +R + Sbjct: 258 TVKFSSSLP-YPNNLNSVLAERLEKW----LQLMLMWHPRQRGT 296 >3QGY-A nrPDB Length = 286 Score = 206 bits (525), Expect = 8e-54, Method: Composition-based stats. Identities = 61/256 (23%), Positives = 114/256 (44%), Gaps = 18/256 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 V++IG G +G+V+ L + VA+K I+ + +E I E ++ +L+HP Sbjct: 28 ELTFVQEIGSGQFGLVHLGYW-LNKDKVAIKTIKEGSMSEDD---FIEEAEVMMKLSHPK 83 Query: 63 IVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +V+L V + + LVFEF+ H L ++ + + +G+A+ Sbjct: 84 LVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-FAAETLLGMCLDVCEGMAYLEEA 142 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARA-FGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 V+HRDL +N L+ IK++DFG+ R + T + + +PE+ Y Sbjct: 143 CVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVF-SFSRY 201 Query: 181 STAVDIWSLGCIFAEMVT-RRALFPGDSEID------QLFRIFRTLGTPDEV---VWPGV 230 S+ D+WS G + E+ + + + S + FR+++ V + Sbjct: 202 SSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCW 261 Query: 231 TSMPDYKPSFPKWARQ 246 P+ +P+F + RQ Sbjct: 262 KERPEDRPAFSRLLRQ 277 >5AMN-A nrPDB Length = 299 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 69/285 (24%), Positives = 126/285 (44%), Gaps = 26/285 (9%) Query: 2 ENFQKVEKIGEGTYGVVYKARN-KLTGE----VVALKKIRLDTETEGVPSTAIREISLLK 56 +N + +GEG +G V KA L G VA+K ++ + + + E ++LK Sbjct: 23 KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELRDLLSEFNVLK 81 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTG--------IPLPLIKSY 107 ++NHP+++KL + L L+ E+ + L+ F+ S G + + + S+ Sbjct: 82 QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISF 141 Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--T 165 +Q+ QG+ + +++HRDL +N+L+ +K++DFGL+R Sbjct: 142 AWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIP 201 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDE 224 + + A E L Y+T D+WS G + E+VT +PG R+F L T Sbjct: 202 VKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP----ERLFNLLKTGHR 256 Query: 225 VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHY 269 + P S Y+ W ++ P + + L +M+ Sbjct: 257 MERPDNCSEEMYRLMLQCWKQEP--DKRPVFADISKDL-EKMMVK 298 >4UY9-A nrPDB Length = 323 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 71/262 (27%), Positives = 109/262 (41%), Gaps = 25/262 (9%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP--STAIREISLLKELNH 60 E IG G +G VY+A G+ VA+K R D + + +E L L H Sbjct: 10 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 67 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 PNI+ L V E L LV EF L + + + IP ++ ++ Q+ +G+ + H Sbjct: 68 PNIIALRGVCLKEPNLCLVMEFARGGPLNRVL---SGKRIPPDILVNWAVQIARGMNYLH 124 Query: 120 SHR---VLHRDLKPQNLLI--------NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWY 168 ++HRDLK N+LI + +K+ DFGLAR + + T + Sbjct: 125 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM--SAAGTYAW 182 Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228 APE++ +S D+WS G + E++T F G ID L + + P Sbjct: 183 MAPEVIRAS-MFSKGSDVWSYGVLLWELLTGEVPFRG---IDGLAVAYGVAMNKLALPIP 238 Query: 229 GVTSMPDYKPSFPKWARQDFSK 250 P K W S+ Sbjct: 239 STCPEPFAKLMEDCWNPDPHSR 260 >5B2L-A nrPDB Length = 324 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 69/294 (23%), Positives = 116/294 (39%), Gaps = 32/294 (10%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 + + + + ++G GT G V+K R + TG V+A+K++R E + +LK + Sbjct: 16 INDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDC 75 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC-H 119 P IV+ T +++ E + +K + IP ++ +++ L + Sbjct: 76 PYIVQCFGTFITNTDVFIAMELMGTSAEK-LKKRMQGPIPERILGKMTVAIVKALYYLKE 134 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL---- 175 H V+HRD+KP N+L++ G IKL DFG++ V + T Y APE + Sbjct: 135 KHGVIHRDVKPSNILLDERGQIKLCDFGISGRL-VDSKAKTRSAGCAAYMAPERIDPPDP 193 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 Y D+WSLG E+ T + + + T EV+ + P Sbjct: 194 TKPDYDIRADVWSLGISLVELATGQFPY-------------KNCKTDFEVLTKVLQEEPP 240 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 P D +S + L D KR L H F + Sbjct: 241 LLPG------------HMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRY 282 >4PDO-A nrPDB Length = 299 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 117/269 (43%), Gaps = 17/269 (6%) Query: 8 EKIGEGTYGVVYKARNK-LTGEV---VALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 + IG G +G VYK K +G+ VA+K ++ TE + E ++ + +H NI Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGY-TEKQRVDFLGEAGIMGQFSHHNI 98 Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123 ++L VI + ++ E++ + + L + G+ + + Sbjct: 99 IRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNY 158 Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVV--TLWYRAPEILLGCKYY 180 +HRDL +N+L+N+ K++DFGL+R P TYT + + APE + + + Sbjct: 159 VHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAI-SYRKF 217 Query: 181 STAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 ++A D+WS G + E++T + S + + I P + P Y+ Sbjct: 218 TSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAI----YQLM 273 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLH 268 W ++ + P D S+L +++ Sbjct: 274 MQCWQQE---RARRPKFADIVSILDKLIR 299 >4PWN-A nrPDB Length = 274 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 120/288 (41%), Gaps = 39/288 (13%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 +IG G++ VYK + T VA +++ T+ E +LK L HPNIV+ D Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYD 76 Query: 69 VIHT----ENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH-- 121 + + + LV E + LK ++ + + +++S+ Q+L+GL F H+ Sbjct: 77 SWESTVKGKKCIVLVTELMTSGTLKTYLKR--FKVMKIKVLRSWCRQILKGLQFLHTRTP 134 Query: 122 RVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 ++HRDLK N+ I G++K+ D GLA + T + APE+ + Y Sbjct: 135 PIIHRDLKCDNIFITGPTGSVKIGDLGLAT-LEKRASFAKSVIGTPEFMAPEMYE--EKY 191 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 +VD+++ G EM T + Q++R + P + Sbjct: 192 DESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAI---------- 241 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + + ++ + + ++R S K L H FFQ+ Sbjct: 242 ----------------PEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >5O2B-A nrPDB Length = 285 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 70/290 (24%), Positives = 126/290 (43%), Gaps = 40/290 (13%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 ++G G + VYK + T VA +++ T+ E +LK L HPNIV+ D Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 69 VIHT----ENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH-- 121 + + + LV E + LK ++ + +++S+ Q+L+GL F H+ Sbjct: 83 SWESILKGKKCIVLVTELMTSGTLKTYLKR--FKVMKPKVLRSWCRQILKGLQFLHTRTP 140 Query: 122 RVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 ++HRDLK N+ I G++K+ D GLA + T + APE+ ++Y Sbjct: 141 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA--KSVIGTPEFMAPEMYE--EHY 196 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 +VD+++ G EM T + SE +I+R + + Sbjct: 197 DESVDVYAFGMCMLEMATSEYPY---SECQNAAQIYRKVTS------------------- 234 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 F+KV D + + ++ + + ++R+S + L H FF + T Sbjct: 235 -GIKPASFNKVT---DPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT 280 >2PSQ-A nrPDB Length = 370 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 68/293 (23%), Positives = 134/293 (45%), Gaps = 39/293 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKA------RNKLTGEV-VALKKIRLDTETEGVPSTAIREISL 54 + + +GEG +G V A ++K V VA+K ++ D TE S + E+ + Sbjct: 81 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DDATEKDLSDLVSEMEM 139 Query: 55 LKEL-NHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPL--------- 103 +K + H NI+ LL + LY++ E+ +L++++ A G+ Sbjct: 140 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 199 Query: 104 -----IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG--VPV 156 + S +QL +G+ + S + +HRDL +N+L+ +K+ADFGLAR Sbjct: 200 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 259 Query: 157 RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRI 215 + T+ + + + APE L + Y+ D+WS G + E+ T + +PG +++LF++ Sbjct: 260 KKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKL 317 Query: 216 FRTLGTPDE----------VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDED 258 + D+ ++ ++P +P+F + + +E+ Sbjct: 318 LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE 370 >5O2C-A nrPDB Length = 380 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 70/290 (24%), Positives = 126/290 (43%), Gaps = 40/290 (13%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 ++G G + VYK + T VA +++ T+ E +LK L HPNIV+ D Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 69 VIHT----ENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH-- 121 + + + LV E + LK ++ + +++S+ Q+L+GL F H+ Sbjct: 92 SWESILKGKKCIVLVTELMTSGTLKTYLKR--FKVMKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 122 RVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 ++HRDLK N+ I G++K+ D GLA + T + APE+ ++Y Sbjct: 150 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA--KSVIGTPEFMAPEMYE--EHY 205 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 +VD+++ G EM T + SE +I+R + + Sbjct: 206 DESVDVYAFGMCMLEMATSEYPY---SECQNAAQIYRKVTS------------------- 243 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 F+KV D + + ++ + + ++R+S + L H FF + T Sbjct: 244 -GIKPASFNKVT---DPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT 289 >4XCU-A nrPDB Length = 300 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 65/267 (24%), Positives = 122/267 (45%), Gaps = 28/267 (10%) Query: 2 ENFQKVEKIGEGTYGVVYKARN------KLTGE-VVALKKIRLDTETEGVPSTAIREISL 54 + + +GEG +G V +A + VA+K ++ D ++ + + E+ + Sbjct: 17 DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK-DNASDKDLADLVSEMEV 75 Query: 55 LKEL-NHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPL-----PLIKSY 107 +K + H NI+ LL V E LY++ E +L++F+ A G P++ S Sbjct: 76 MKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSC 135 Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--T 165 +Q+ +G+ + S + +HRDL +N+L+ + +K+ADFGLAR Sbjct: 136 AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 195 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEID------QLFRIFRT 218 + + APE L + Y+ D+WS G + E+ T + +PG + + R+ R Sbjct: 196 VKWMAPEALFD-RVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRP 254 Query: 219 LGTPDE---VVWPGVTSMPDYKPSFPK 242 P E ++ + P +P+F + Sbjct: 255 PHCPPELYGLMRECWHAAPSQRPTFKQ 281 >1BYG-A nrPDB Length = 278 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 65/289 (22%), Positives = 119/289 (41%), Gaps = 44/289 (15%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 M+ + ++ IG+G +G V + G VA+K I+ D + E S++ +L H Sbjct: 20 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKND----ATAQAFLAEASVMTQLRH 73 Query: 61 PNIVKLLDVI-HTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 N+V+LL VI + LY+V E++ L ++ + + + + + + + + + Sbjct: 74 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL 133 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178 + +HRDL +N+L++ + K++DFGL + T V + APE L K Sbjct: 134 EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV---KWTAPEALRE-K 189 Query: 179 YYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237 +ST D+WS G + E+ + R +P D + R+ + Sbjct: 190 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGY------------------ 231 Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS---AKAALAH 283 + D PP + + H D R S + L H Sbjct: 232 -------KMDAPDGCPPAVYEV---MKNCWHLDAAMRPSFLQLREQLEH 270 >5EG3-A nrPDB Length = 334 Score = 205 bits (521), Expect = 2e-53, Method: Composition-based stats. Identities = 69/297 (23%), Positives = 135/297 (45%), Gaps = 39/297 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKA------RNKLTGEV-VALKKIRLDTETEGVPSTAIREISL 54 + + +GEG +G V A ++K V VA+K ++ D TE S + E+ + Sbjct: 35 DKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DDATEKDLSDLVSEMEM 93 Query: 55 LKEL-NHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPL----------- 101 +K + H NI+ LL + LY++ + +L++++ A G+ L Sbjct: 94 MKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQ 153 Query: 102 ---PLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV-- 156 + S +QL +G+ + S + +HRDL +N+L+ +K+ADFGLAR Sbjct: 154 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFF 213 Query: 157 RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRI 215 + T+ + + + APE L + Y+ D+WS G + E+ T + +PG +++LF++ Sbjct: 214 KETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKL 271 Query: 216 FRTLGTPDE----------VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSL 262 + D+ ++ ++P +P+F + + +E+ L Sbjct: 272 LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDL 328 >6DBM-A nrPDB Length = 318 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 71/282 (25%), Positives = 120/282 (42%), Gaps = 26/282 (9%) Query: 4 FQKVEKIGEGTYGVV----YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 +K+ +GEG +G V Y N TGE+VA+K ++ D + S +EI +L+ L Sbjct: 33 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQ-HRSGWKQEIDILRTLY 91 Query: 60 HPNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 H +I+K L LV E++ L D I L + + Q+ +G+A+ Sbjct: 92 HEHIIKYKGCCEDAGAASLQLVMEYVP--LGSLRDYLPRHSIGLAQLLLFAQQICEGMAY 149 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV---VTLWYRAPEIL 174 HS +HRDL +N+L++ + +K+ DFGLA+A Y +++ APE L Sbjct: 150 LHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECL 209 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 K+Y A D+WS G E++T DS + +G + G ++ Sbjct: 210 KEYKFY-YASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELIG-----IAQGQMTVL 258 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS 276 + R P + L+ + + R + Sbjct: 259 RLTELLERGERLPRPDKCPA---EVYHLMKNCWETEASFRPT 297 >1FVR-A nrPDB Length = 327 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 68/270 (25%), Positives = 123/270 (45%), Gaps = 31/270 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVV--ALKKIRLDTETEGVPSTAIREISLLKEL- 58 + + + IGEG +G V KAR K G + A+K+++ + ++ E+ +L +L Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMK-EYASKDDHRDFAGELEVLCKLG 83 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASAL--------------TGIPLPL 103 +HPNI+ LL LYL E+ H +L F+ S + + + Sbjct: 84 HHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQ 143 Query: 104 IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV 163 + + + +G+ + + +HRDL +N+L+ K+ADFGL+R V V+ + Sbjct: 144 LLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRL 203 Query: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDS------EIDQLFRIF 216 + + A E L Y+T D+WS G + E+V+ + G + ++ Q +R+ Sbjct: 204 -PVRWMAIESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLE 261 Query: 217 RTLGTPDEV---VWPGVTSMPDYKPSFPKW 243 + L DEV + P +PSF + Sbjct: 262 KPLNCDDEVYDLMRQCWREKPYERPSFAQI 291 >5VO2-A nrPDB Length = 300 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 70/283 (24%), Positives = 115/283 (40%), Gaps = 43/283 (15%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E ++ +G G G V+ R GE VA+KK+R ET+ I L++L HP Sbjct: 12 EEILDLQWVGSGAQGAVFLGR--FHGEEVAVKKVRDLKETD---------IKHLRKLKHP 60 Query: 62 NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 NI+ V ++ EF L + + A + L+ + + G+ + H Sbjct: 61 NIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRP--VTPSLLVDWSMGIAGGMNYLHL 118 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 H+++HRDLK N+LI + +K++DFG ++ T T+ + APE++ + Sbjct: 119 HKIIHRDLKSPNMLITYDDVVKISDFGTSKELS-DKSTKMSFAGTVAWMAPEVIRN-EPV 176 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 S VDIWS G + E++T + + GV S + P Sbjct: 177 SEKVDIWSFGVVLWELLTGEIPYKDVD---------------SSAIIWGVGSNSLHLP-- 219 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAH 283 V + + LL Q + P R S + L H Sbjct: 220 ----------VPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH 252 >3OMV-A nrPDB Length = 307 Score = 204 bits (520), Expect = 3e-53, Method: Composition-based stats. Identities = 57/254 (22%), Positives = 115/254 (45%), Gaps = 24/254 (9%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 +IG G++G VYK + VA+K +++ T E+++L++ H NI+ + Sbjct: 43 RIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMG 99 Query: 69 VIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 T++ L +V ++ L K + T + + Q QG+ + H+ ++HRD Sbjct: 100 -YMTKDNLAIVTQWCEGSSLYKHLHVQE-TKFQMFQLIDIARQTAQGMDYLHAKNIIHRD 157 Query: 128 LKPQNLLINTEGAIKLADFGLA--RAFGVPVRTYTHEVVTLWYRAPEIL--LGCKYYSTA 183 +K N+ ++ +K+ DFGLA ++ + ++ + APE++ +S Sbjct: 158 MKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ 217 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQ-LFRIFRTLGTPD-------------EVVWPG 229 D++S G + E++T + + DQ +F + R +PD +V Sbjct: 218 SDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADC 277 Query: 230 VTSMPDYKPSFPKW 243 V + + +P FP+ Sbjct: 278 VKKVKEERPLFPQI 291 >4IAN-A nrPDB Length = 358 Score = 204 bits (520), Expect = 3e-53, Method: Composition-based stats. Identities = 91/327 (27%), Positives = 147/327 (44%), Gaps = 46/327 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLT-GEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 + + G+G + V +AR+ + VA+K IR + E + T ++E+ LK+LN Sbjct: 30 KRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNN---ELMQKTGLKELEFLKKLND 86 Query: 61 P------NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALT-GIPLPLIKSYLFQLLQ 113 + ++L + + L LVFE L +L++ + G+ + ++SY QL Sbjct: 87 ADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFL 146 Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGAI-KLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 L +LH D+KP N+L+N I KL DFG A V T +V+ +YRAPE Sbjct: 147 ALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSAS--HVADNDITPYLVSRFYRAPE 204 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGT-PDEVVWPGVT 231 I++G K Y +D+WS+GC E+ T + LFPG + L G P++++ GV Sbjct: 205 IIIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVF 263 Query: 232 SMPDYKPSF-------PKWARQDFSKVVPPLDE-----------------------DGRS 261 + + K ++ V+ ++ + Sbjct: 264 KDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKD 323 Query: 262 LLSQMLHYDPNKRISAKAALAHPFFQD 288 LL Q+L DP KRIS AL H F Q+ Sbjct: 324 LLDQILMLDPAKRISINQALQHAFIQE 350 >3DTC-A nrPDB Length = 271 Score = 204 bits (520), Expect = 3e-53, Method: Composition-based stats. Identities = 70/262 (26%), Positives = 108/262 (41%), Gaps = 25/262 (9%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP--STAIREISLLKELNH 60 E IG G +G VY+A G+ VA+K R D + + +E L L H Sbjct: 8 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 65 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 PNI+ L V E L LV EF L + + + IP ++ ++ Q+ +G+ + H Sbjct: 66 PNIIALRGVCLKEPNLCLVMEFARGGPLNRVL---SGKRIPPDILVNWAVQIARGMNYLH 122 Query: 120 SHR---VLHRDLKPQNLLI--------NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWY 168 ++HRDLK N+LI + +K+ DFGLAR + + + Sbjct: 123 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM--SAAGAYAW 180 Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228 APE++ +S D+WS G + E++T F G ID L + + P Sbjct: 181 MAPEVIRAS-MFSKGSDVWSYGVLLWELLTGEVPFRG---IDGLAVAYGVAMNKLALPIP 236 Query: 229 GVTSMPDYKPSFPKWARQDFSK 250 P K W S+ Sbjct: 237 STCPEPFAKLMEDCWNPDPHSR 258 >3BBT-B nrPDB Length = 328 Score = 204 bits (519), Expect = 4e-53, Method: Composition-based stats. Identities = 64/279 (22%), Positives = 123/279 (44%), Gaps = 20/279 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVV----ALKKIRLDTETEGVPSTAIREISLLKEL 58 ++V+ +G G +G VYK GE V A+K + T + + E ++ + Sbjct: 16 ELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE-FMDEALIMASM 74 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 +HP++V+LL V + + LV + + H L +++ I L+ ++ Q+ +G+ + Sbjct: 75 DHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDN-IGSQLLLNWCVQIAKGMMY 132 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--TLWYRAPEILL 175 R++HRDL +N+L+ + +K+ DFGLAR + Y + + + A E + Sbjct: 133 LEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIH 192 Query: 176 GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 + ++ D+WS G E++T + G + I L + + P + ++ Sbjct: 193 -YRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTRE----IPDLLEKGERLPQPPICTID 247 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNK 273 Y W S+ P E S+M DP + Sbjct: 248 VYMVMVKCWMIDADSR--PKFKELAAEF-SRM-ARDPQR 282 >4Y93-A nrPDB Length = 446 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 53/252 (21%), Positives = 115/252 (45%), Gaps = 20/252 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEV-VALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ ++++G G +GVV K G+ VA+K I+ + +E I E ++ L+H Sbjct: 188 KDLTFLKELGTGQFGVVK--YGKWRGQYDVAIKMIKEGSMSE---DEFIEEAKVMMNLSH 242 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 +V+L V + ++++ E++ + L ++ + + + + + Sbjct: 243 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEYLE 301 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARA-FGVPVRTYTHEVVTLWYRAPEILLGCK 178 S + LHRDL +N L+N +G +K++DFG+ R + T + + +PE+L+ K Sbjct: 302 SKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSK 361 Query: 179 YYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDE---------VVWP 228 +S+ DIW+ G + E+ + + + + + I + L P +++ Sbjct: 362 -FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAIMYS 420 Query: 229 GVTSMPDYKPSF 240 D +P+F Sbjct: 421 CWHEKADERPTF 432 >2WTK-B nrPDB Length = 373 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 68/323 (21%), Positives = 119/323 (36%), Gaps = 34/323 (10%) Query: 4 FQKVEKIGEGTYG---VVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ + IG+G + V AR K TGE V +++I L+ + + + E+ + K NH Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNH 69 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 PNIV +N+L++V F+ + K + + G+ I L +L+ L + H Sbjct: 70 PNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIH 129 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV---------TLWYRA 170 +HR +K ++LI+ +G + L+ GL + VV L + + Sbjct: 130 HMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLS 187 Query: 171 PEIL-LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRT----------- 218 PE+L + Y DI+S+G E+ F L Sbjct: 188 PEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTI 247 Query: 219 ------LGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPN 272 + V G++ P + Q L +P+ Sbjct: 248 PAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPD 307 Query: 273 KRISAKAALAHPFFQDVTKPVPH 295 R SA L H FF+ + + Sbjct: 308 ARPSASTLLNHSFFKQIKRRASE 330 >5HI2-A nrPDB Length = 283 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 61/279 (21%), Positives = 122/279 (43%), Gaps = 37/279 (13%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 ++IG G++G VYK + VA+K + T E+ +L++ H N Sbjct: 21 QITVGQRIGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNEVGVLRKTRHVN 72 Query: 63 IVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 I+ + T+ +L +V ++ L + AS T + + Q +G+ + H+ Sbjct: 73 ILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHASE-TKFEMKKLIDIARQTARGMDYLHAK 130 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE--VVTLWYRAPEIL--LGC 177 ++HRDLK N+ ++ + +K+ DFGLA ++ E ++ + APE++ Sbjct: 131 SIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDS 190 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF-RTLGTPD------------- 223 YS D+++ G + E++T + + + DQ+ + R +PD Sbjct: 191 NPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMK 250 Query: 224 EVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSL 262 ++ + D +PSFP+ ++ ++E R L Sbjct: 251 RLMAECLKKKRDERPSFPR--------ILAEIEELAREL 281 >2OGV-A nrPDB Length = 317 Score = 203 bits (518), Expect = 5e-53, Method: Composition-based stats. Identities = 60/267 (22%), Positives = 108/267 (40%), Gaps = 30/267 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEV-----VALKKIRLDTETEGVPSTAIREISLLK 56 N Q + +G G +G V +A G+ VA+K ++ T + E+ ++ Sbjct: 38 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALMSELKIMS 96 Query: 57 EL-NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFM--------DASALTGIPLPLIKS 106 L H NIV LL + ++ E+ + DL F+ D + L + Sbjct: 97 HLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLH 156 Query: 107 YLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT--YTHEVV 164 + Q+ QG+AF S +HRD+ +N+L+ K+ DFGLAR + + Sbjct: 157 FSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARL 216 Query: 165 TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD----------SEIDQLF 213 + + APE + C Y+ D+WS G + E+ + +PG + Q+ Sbjct: 217 PVKWMAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMA 275 Query: 214 RIFRTLGTPDEVVWPGVTSMPDYKPSF 240 + ++ P ++P+F Sbjct: 276 QPAFAPKNIYSIMQACWALEPTHRPTF 302 >4XI2-A nrPDB Length = 446 Score = 203 bits (517), Expect = 8e-53, Method: Composition-based stats. Identities = 61/272 (22%), Positives = 122/272 (44%), Gaps = 25/272 (9%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEV-VALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ ++++G G +GVV K G+ VA+K IR + +E I E ++ L+H Sbjct: 187 KDLTFLKELGTGQFGVVK--YGKWRGQYDVAIKMIREGSMSE---DEFIEEAKVMMNLSH 241 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 +V+L V + ++++ E++ + L ++ + + + + + Sbjct: 242 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEYLE 300 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV---TLWYRAPEILLG 176 S + LHRDL +N L+N +G +K++DFGL+R YT V + + PE+L+ Sbjct: 301 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD--EYTSSVGSKFPVRWSPPEVLMY 358 Query: 177 CKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 K +S+ DIW+ G + E+ + + + + + I + L + P + S Sbjct: 359 SK-FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGL----RLYRPHLASERV 413 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQML 267 Y + W + + + LLS +L Sbjct: 414 YTIMYSCWHEKADER------PSFKILLSNIL 439 >1LUF-A nrPDB Length = 343 Score = 203 bits (516), Expect = 9e-53, Method: Composition-based stats. Identities = 63/279 (22%), Positives = 123/279 (44%), Gaps = 42/279 (15%) Query: 2 ENFQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETEGVPSTAIREISLLK 56 N + V IGEG +G V++AR +VA+K ++ + + + + RE +L+ Sbjct: 47 NNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLK-EEASADMQADFQREAALMA 105 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALT------------------ 97 E ++PNIVKLL V + L+FE++ + DL +F+ + + Sbjct: 106 EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSS 165 Query: 98 ----GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG 153 + Q+ G+A+ + +HRDL +N L+ +K+ADFGL+R Sbjct: 166 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 225 Query: 154 --VPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEID 210 + ++ + + + PE + Y+T D+W+ G + E+ + + G + + Sbjct: 226 SADYYKADGNDAIPIRWMPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEE 284 Query: 211 QLF--RIFRTLGTPD-------EVVWPGVTSMPDYKPSF 240 ++ R L P+ ++ + +P +PSF Sbjct: 285 VIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSF 323 >4K33-A nrPDB Length = 325 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 64/280 (22%), Positives = 125/280 (44%), Gaps = 39/280 (13%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGE-------VVALKKIRLDTETEGVPSTAIREISLL 55 + +GEG +G V A + VA+K ++ D T+ S + E+ ++ Sbjct: 37 RLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLK-DDATDKDLSDLVSEMEMM 95 Query: 56 KEL-NHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPL------------ 101 K + H NI+ LL LY++ E+ +L++F+ A G+ Sbjct: 96 KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQL 155 Query: 102 --PLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG--VPVR 157 + S +Q+ +G+ + S + +HRDL +N+L+ + +K+ADFGLAR + Sbjct: 156 TFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYK 215 Query: 158 TYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIF 216 T+ + + + APE L + Y+ D+WS G + E+ T + +PG +++LF++ Sbjct: 216 ETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-PVEELFKLL 273 Query: 217 RTLGTPDE----------VVWPGVTSMPDYKPSFPKWARQ 246 + D+ ++ + P +P+F + Sbjct: 274 KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVED 313 >5VD3-A nrPDB Length = 311 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 78/288 (27%), Positives = 120/288 (41%), Gaps = 35/288 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NH 60 ++FQ++ ++G G+YG V+K R+K G + A+K+ + + E+ +++ H Sbjct: 57 QSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQH 116 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 P V+L LYL E L++ +A + +P + YL L LA HS Sbjct: 117 PCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGAS-LPEAQVWGYLRDTLLALAHLHS 175 Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 ++H D+KP N+ + G KL DFGL G E Y APE+L G Y Sbjct: 176 QGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQE-GDPRYMAPELLQGS--Y 232 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 TA D++SLG E+ L G QL + + Sbjct: 233 GTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPP--------------------- 271 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + L + RS+L ML DP R +A+A LA P + Sbjct: 272 ---------EFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ 310 >4E20-A nrPDB Length = 290 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 70/283 (24%), Positives = 125/283 (44%), Gaps = 28/283 (9%) Query: 4 FQKVEKIGEGTYGVV----YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 +K+ +GEG +G V Y N TGE+VA+K ++ + + S REI +L+ L Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQ-LRSGWQREIEILRTLY 68 Query: 60 HPNIVKLLDVIHTENK--LYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 H +IVK + + + LV E++ L D + L + + Q+ +G+A+ Sbjct: 69 HEHIVKYKGCCEDQGEKSVQLVMEYVP--LGSLRDYLPRHCVGLAQLLLFAQQICEGMAY 126 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV---VTLWYRAPEIL 174 H+ +HR L +N+L++ + +K+ DFGLA+A Y +++ APE L Sbjct: 127 LHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECL 186 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLG-TPDEVVWPGVTSM 233 CK+Y A D+WS G E++T DS + +G T ++ +T + Sbjct: 187 KECKFY-YASDVWSFGVTLYELLTYC-----DSNQSPHTKFTELIGHTQGQMTVLRLTEL 240 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS 276 + P+ R + L+ + + R + Sbjct: 241 LERGERLPRPDRCPC---------EIYHLMKNCWETEASFRPT 274 >3BEA-A nrPDB Length = 333 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 58/271 (21%), Positives = 108/271 (39%), Gaps = 34/271 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEV-----VALKKIRLDTETEGVPSTAIREISLLK 56 N Q + +G G +G V +A G+ VA+K ++ T + E+ ++ Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALMSELKIMS 104 Query: 57 EL-NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASAL------------TGIPLP 102 L H NIV LL + ++ E+ + DL F+ + + + Sbjct: 105 HLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTR 164 Query: 103 LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT--YT 160 + + Q+ QG+AF S +HRD+ +N+L+ K+ DFGLAR Sbjct: 165 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKG 224 Query: 161 HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD----------SEI 209 + + + + APE + C Y+ D+WS G + E+ + +PG + Sbjct: 225 NARLPVKWMAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDG 283 Query: 210 DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 Q+ + ++ P ++P+F Sbjct: 284 YQMAQPAFAPKNIYSIMQACWALEPTHRPTF 314 >3SXS-A nrPDB Length = 268 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 62/254 (24%), Positives = 123/254 (48%), Gaps = 24/254 (9%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEV-VALKKIRLDTETEGVPSTAIREISLLKELNH 60 E ++++G G +GVV + K G+ VA+K I+ + +E +E + +L+H Sbjct: 8 EEITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSED---EFFQEAQTMMKLSH 62 Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 P +VK V E +Y+V E++ L ++ + G+ + + + +G+AF Sbjct: 63 PKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHG-KGLEPSQLLEMCYDVCEGMAFLE 121 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTL---WYRAPEILLG 176 SH+ +HRDL +N L++ + +K++DFG+ R Y V T + APE+ Sbjct: 122 SHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDD--QYVSSVGTKFPVKWSAPEVFHY 179 Query: 177 CKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEID------QLFRIFRTLGTPD---EVV 226 K YS+ D+W+ G + E+ + + + + + Q R++R D +++ Sbjct: 180 FK-YSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIM 238 Query: 227 WPGVTSMPDYKPSF 240 + +P+ +P+F Sbjct: 239 YSCWHELPEKRPTF 252 >3ORP-A nrPDB Length = 311 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 64/240 (26%), Positives = 105/240 (43%), Gaps = 12/240 (5%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIREISLLKELNH 60 + ++ E +G G V+ AR+ VA+K +R D + RE LNH Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNH 71 Query: 61 PNIVKLLDVIHTENKL----YLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 P IV + D E Y+V E++ L+ + + + Q L Sbjct: 72 PAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGP--MTPKRAIEVIADACQAL 129 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE---VVTLWYRAPE 172 F H + ++HRD+KP N++I+ A+K+ DFG+ARA + T + T Y +PE Sbjct: 130 NFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPE 189 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 G D++SLGC+ E++T F GDS + ++ R P G+++ Sbjct: 190 QARGDSV-DARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSA 248 >3KRL-A nrPDB Length = 335 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 107/273 (39%), Gaps = 36/273 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEV-----VALKKIRLDTETEGVPSTAIREISLLK 56 N Q + +G G +G V +A G+ VA+K ++ T + E+ ++ Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALMSELKIMS 104 Query: 57 EL-NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPL----------- 103 L H NIV LL + ++ E+ + DL F+ G+ Sbjct: 105 HLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLS 164 Query: 104 ---IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT-- 158 + + Q+ QG+AF S +HRD+ +N+L+ K+ DFGLAR Sbjct: 165 SRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIV 224 Query: 159 YTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD----------S 207 + + + + APE + C Y+ D+WS G + E+ + +PG Sbjct: 225 KGNARLPVKWMAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK 283 Query: 208 EIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240 + Q+ + ++ P ++P+F Sbjct: 284 DGYQMAQPAFAPKNIYSIMQACWALEPTHRPTF 316 >5KMM-A nrPDB Length = 329 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 59/294 (20%), Positives = 111/294 (37%), Gaps = 53/294 (18%) Query: 9 KIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 ++GEG +G V+ A +VA+K ++ +E RE LL L H +I Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK--EASESARQDFQREAELLTMLQHQHI 99 Query: 64 VKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALT-------------GIPLPLIKSYLF 109 V+ V L +VFE++ H DL +F+ + + L + + Sbjct: 100 VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVAS 159 Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYTHEVVTLW 167 Q+ G+ + +HRDL +N L+ +K+ DFG++R R ++ + Sbjct: 160 QVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR 219 Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVV 226 + PE +L + ++T D+WS G + E+ T + + S + + I + Sbjct: 220 WMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRA 278 Query: 227 WPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA 280 P + +++ +P +R S K Sbjct: 279 CP----------------------------PEVYAIMRGCWQREPQQRHSIKDV 304 >2JD5-A nrPDB Length = 373 Score = 201 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 90/327 (27%), Positives = 142/327 (43%), Gaps = 48/327 (14%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP- 61 + V K+G G + V+ A++ + VA+K +R D + A EI LL+ +N Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGD---KVYTEAAEDEIKLLQRVNDAD 76 Query: 62 ----------NIVKLLDVIHTEN----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSY 107 +I+KLLD + + + +VFE L ++L + GIPL +K Sbjct: 77 NTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQI 136 Query: 108 LFQLLQGLAFCHSH-RVLHRDLKPQNLL---INTEG---AIKLADFGLARAFGVPVRTYT 160 QLL GL + H ++H D+KP+N+L +++ IK+AD G A + YT Sbjct: 137 SKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYD---EHYT 193 Query: 161 HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGD------SEIDQLFR 214 + + T YR+PE+LLG + DIWS C+ E++T LF D + D + + Sbjct: 194 NSIQTREYRSPEVLLGA-PWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQ 252 Query: 215 IFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLD----------EDGR---S 261 I LG + + S K P D ++ + Sbjct: 253 IIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISD 312 Query: 262 LLSQMLHYDPNKRISAKAALAHPFFQD 288 LS ML DP KR A + HP+ +D Sbjct: 313 FLSPMLQLDPRKRADAGGLVNHPWLKD 339 >1ZXE-A nrPDB Length = 303 Score = 201 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 77/312 (24%), Positives = 131/312 (41%), Gaps = 59/312 (18%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 +F+++ +G+G +G V KARN L A+KKIR TE ST + E+ LL LNH Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRH---TEEKLSTILSEVMLLASLNHQY 63 Query: 63 IVKLLDVIHT-------------ENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYL 108 +V+ ++ L++ E+ L + + L + Sbjct: 64 VVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWR-LF 122 Query: 109 FQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV-------------- 154 Q+L+ L++ HS ++HR+LKP N+ I+ +K+ DFGLA+ Sbjct: 123 RQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPG 182 Query: 155 PVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR 214 T + T Y A E+L G +Y+ +D++SLG IF EM+ F E + + Sbjct: 183 SSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVNILK 239 Query: 215 IFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 274 R++ ++ P F + K+ + ++ +DPNKR Sbjct: 240 KLRSVSI-------------EFPPDFDDNKMKVEKKI-----------IRLLIDHDPNKR 275 Query: 275 ISAKAALAHPFF 286 A+ L + Sbjct: 276 PGARTLLNSGWL 287 >5FM2-A nrPDB Length = 355 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 126/299 (42%), Gaps = 40/299 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARN-KLTGE----VVALKKIRLDTETEGVPSTAIREISLLK 56 +N + +GEG +G V KA L G VA+K ++ + + + E ++LK Sbjct: 64 KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELRDLLSEFNVLK 122 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTG----------------- 98 ++NHP+++KL + L L+ E+ + L+ F+ S G Sbjct: 123 QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH 182 Query: 99 -----IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG 153 + + + S+ +Q+ QG+ + +++HRDL +N+L+ +K++DFGL+R Sbjct: 183 PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 242 Query: 154 VPVRTYTHEVV--TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEID 210 + + A E L Y+T D+WS G + E+VT +PG Sbjct: 243 EEDSYVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP-- 299 Query: 211 QLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHY 269 R+F L T + P S Y+ W ++ P + + L +M+ Sbjct: 300 --ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEP--DKRPVFADISKDL-EKMMVK 353 >3KUL-B nrPDB Length = 325 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 58/284 (20%), Positives = 111/284 (39%), Gaps = 20/284 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEV---VALKKIRLDTETEGVPSTAIREISLLKELN 59 + IG G G V R ++ G+ VA+K ++ TE + E S++ + + Sbjct: 50 RIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY-TERQRRDFLSEASIMGQFD 108 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 HPNI++L V+ +V E++ L F+ + + L + G+ + Sbjct: 109 HPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQ-FTIMQLVGMLRGVGAGMRYL 167 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR---TYTHEVVTLWYRAPEILL 175 +HRDL +N+L+++ K++DFGL+R T T + + + APE + Sbjct: 168 SDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAI- 226 Query: 176 GCKYYSTAVDIWSLGCIFAE-MVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 + +S+A D+WS G + E + + + D + + P + P Sbjct: 227 AFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHAL--- 283 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNK-RISA 277 ++ W + + L P R +A Sbjct: 284 -HQLMLDCWHKDRAQRPRFSQIVSVLD----ALIRSPESLRATA 322 >6E4F-A nrPDB Length = 290 Score = 201 bits (511), Expect = 3e-52, Method: Composition-based stats. Identities = 60/272 (22%), Positives = 122/272 (44%), Gaps = 25/272 (9%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEV-VALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++ ++++G G +GVV K G+ VA+K I+ + +E I E ++ L+H Sbjct: 31 KDLTFLKELGTGQFGVVK--YGKWRGQYDVAIKMIKEGSMSE---DEFIEEAKVMMNLSH 85 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 +V+L V + ++++ E++ + L ++ + + + + + Sbjct: 86 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEYLE 144 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV---TLWYRAPEILLG 176 S + LHRDL +N L+N +G +K++DFGL+R YT V + + PE+L+ Sbjct: 145 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD--EYTSSVGSKFPVRWSPPEVLMY 202 Query: 177 CKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 K +S+ DIW+ G + E+ + + + + + I + L + P + S Sbjct: 203 SK-FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGL----RLYRPHLASEKV 257 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQML 267 Y + W + + + LLS +L Sbjct: 258 YTIMYSCWHEKADER------PTFKILLSNIL 283 >6DBN-A nrPDB Length = 316 Score = 201 bits (511), Expect = 3e-52, Method: Composition-based stats. Identities = 72/283 (25%), Positives = 129/283 (45%), Gaps = 26/283 (9%) Query: 4 FQKVEKIGEGTYGVVYKARNKL----TGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 +++ +GEG +G V R TGE VA+K ++ ++ + +EI +L+ L Sbjct: 37 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIAD-LKKEIEILRNLY 95 Query: 60 HPNIVKLLDVIHTE--NKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 H NIVK + + N + L+ EFL LK+++ + I L Y Q+ +G+ Sbjct: 96 HENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK-NKINLKQQLKYAVQICKGMD 154 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT---HEVVTLWYRAPEI 173 + S + +HRDL +N+L+ +E +K+ DFGL +A YT +++ APE Sbjct: 155 YLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC 214 Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233 L+ K+Y A D+WS G E++T DS+ + + +G G ++ Sbjct: 215 LMQSKFY-IASDVWSFGVTLHELLTYC-----DSDSSPMALFLKMIGPTH-----GQMTV 263 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS 276 + + R P ++ L+ + + P+ R S Sbjct: 264 TRLVNTLKEGKRLPCPPNCP---DEVYQLMRKCWEFQPSNRTS 303 >4XUF-A nrPDB Length = 297 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 60/281 (21%), Positives = 112/281 (39%), Gaps = 43/281 (15%) Query: 2 ENFQKVEKIGEGTYGVVYKARN---KLTG--EVVALKKIRLDTETEGVPSTAIREISLLK 56 EN + + +G G +G V A TG VA+K ++ + + E+ ++ Sbjct: 9 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSELKMMT 67 Query: 57 EL-NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASA------------------- 95 +L +H NIV LL +YL+FE+ + DL ++ + Sbjct: 68 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEE 127 Query: 96 --LTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG 153 L + + + +Q+ +G+ F +HRDL +N+L+ +K+ DFGLAR Sbjct: 128 EDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIM 187 Query: 154 VPVRT--YTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEID 210 + + + + APE L Y+ D+WS G + E+ + +PG Sbjct: 188 SDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDA 246 Query: 211 QLFRIFRTLGTPDE----------VVWPGVTSMPDYKPSFP 241 +++ + D+ ++ +PSFP Sbjct: 247 NFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFP 287 >5X02-A nrPDB Length = 347 Score = 200 bits (508), Expect = 9e-52, Method: Composition-based stats. Identities = 60/281 (21%), Positives = 112/281 (39%), Gaps = 43/281 (15%) Query: 2 ENFQKVEKIGEGTYGVVYKARN---KLTG--EVVALKKIRLDTETEGVPSTAIREISLLK 56 EN + + +G G +G V A TG VA+K ++ + + E+ ++ Sbjct: 48 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSELKMMT 106 Query: 57 EL-NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASA------------------- 95 +L +H NIV LL +YL+FE+ + DL ++ + Sbjct: 107 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEE 166 Query: 96 --LTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG 153 L + + + +Q+ +G+ F +HRDL +N+L+ +K+ DFGLAR Sbjct: 167 EDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIM 226 Query: 154 VPVRT--YTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEID 210 + + + + APE L Y+ D+WS G + E+ + +PG Sbjct: 227 SDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDA 285 Query: 211 QLFRIFRTLGTPDE----------VVWPGVTSMPDYKPSFP 241 +++ + D+ ++ +PSFP Sbjct: 286 NFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFP 326 >5HIE-A nrPDB Length = 302 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 57/260 (21%), Positives = 113/260 (43%), Gaps = 29/260 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 ++IG G++G VYK + VA+K + T E+ +L++ H N Sbjct: 37 QITVGQRIGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNEVGVLRKTRHVN 88 Query: 63 IVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 I+ + T+ +L +V ++ L + T + + Q QG+ + H+ Sbjct: 89 ILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHI-IETKFEMIKLIDIARQTAQGMDYLHAK 146 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE--VVTLWYRAPEIL--LGC 177 ++HRDLK N+ ++ + +K+ DFGLA ++ E ++ + APE++ Sbjct: 147 SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDK 206 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQ-LFRIFRTLGTPD------------- 223 YS D+++ G + E++T + + + DQ +F + R +PD Sbjct: 207 NPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMK 266 Query: 224 EVVWPGVTSMPDYKPSFPKW 243 ++ + D +P FP+ Sbjct: 267 RLMAECLKKKRDERPLFPQI 286 >3QA8-A nrPDB Length = 676 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 72/249 (28%), Positives = 117/249 (46%), Gaps = 14/249 (5%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 ++ E++G G +G V + ++ TGE VA+K+ R + + + EI ++K+LNHPN+ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCL-EIQIMKKLNHPNV 74 Query: 64 VKLLDVIHTENKL------YLVFEFLHQ-DLKKFMDA-SALTGIPLPLIKSYLFQLLQGL 115 V +V KL L E+ DL+K+++ G+ I++ L + L Sbjct: 75 VSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSAL 134 Query: 116 AFCHSHRVLHRDLKPQNLLIN---TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 + H +R++HRDLKP+N+++ K+ D G A+ T V TL Y APE Sbjct: 135 RYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQG-ELCTEFVGTLQYLAPE 193 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 LL K Y+ VD WS G + E +T F + + Q R VV+ +T Sbjct: 194 -LLEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEHIVVYDDLTG 252 Query: 233 MPDYKPSFP 241 + P Sbjct: 253 AVKFSSVLP 261 >5GNK-A nrPDB Length = 297 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 61/272 (22%), Positives = 122/272 (44%), Gaps = 21/272 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVV----ALKKIRLDTETEGVPSTAIREISLLKEL 58 F+K++ +G G +G VYK GE V A+K++R T + + E ++ + Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE-ILDEAYVMASV 78 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 ++P++ +LL + T + L+ + + L ++ I + ++ Q+ +G+ + Sbjct: 79 DNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDN-IGSQYLLNWCVQIAKGMNY 136 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--TLWYRAPEILL 175 R++HRDL +N+L+ T +K+ DFGLA+ G + Y E + + A E +L Sbjct: 137 LEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL 196 Query: 176 GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 + Y+ D+WS G E++T + G + I L + + P + ++ Sbjct: 197 -HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASE----ISSILEKGERLPQPPICTID 251 Query: 235 DYKPSFPKW-----ARQDFSKVVPPLDEDGRS 261 Y W +R F +++ + R Sbjct: 252 VYMIMVKCWMIDADSRPKFRELIIEFSKMARD 283 >4H1J-A nrPDB Length = 293 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 58/285 (20%), Positives = 120/285 (42%), Gaps = 38/285 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKAR---NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL 58 E+ +GEG +G VY+ +K VA+K + D + + E ++K L Sbjct: 24 EDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNL 82 Query: 59 NHPNIVKLLDVIHTENKLYLVFE-FLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 +HP+IVKL+ +I E +++ E + + +L +++ + + + + Y Q+ + +A+ Sbjct: 83 DHPHIVKLIGIIEEEPT-WIIMELYPYGELGHYLERNK-NSLKVLTLVLYSLQICKAMAY 140 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILLG 176 S +HRD+ +N+L+ + +KL DFGL+R + + + + +PE + Sbjct: 141 LESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESI-N 199 Query: 177 CKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 + ++TA D+W E+++ + F D + + + P + P V Sbjct: 200 FRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYT-- 257 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA 280 L+++ YDP+ R Sbjct: 258 --------------------------LMTRCWDYDPSDRPRFTEL 276 >4R7H-A nrPDB Length = 343 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 59/285 (20%), Positives = 108/285 (37%), Gaps = 43/285 (15%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEV-----VALKKIRLDTETEGVPSTAIREISLLK 56 N Q + +G G +G V +A G+ VA+K ++ T + E+ ++ Sbjct: 50 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALMSELKIMS 108 Query: 57 EL-NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFM---------------------DA 93 L H NIV LL + ++ E+ + DL F+ D Sbjct: 109 HLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDK 168 Query: 94 SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG 153 + L + + Q+ QG+AF S +HRD+ +N+L+ K+ DFGLAR Sbjct: 169 EDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIM 228 Query: 154 VPVRT--YTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD---- 206 + + + + APE + Y+ D+WS G + E+ + +PG Sbjct: 229 NDSNYIVKGNARLPVKWMAPESIFDS-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNS 287 Query: 207 ------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR 245 + Q+ + ++ P ++P+F + Sbjct: 288 KFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQITS 332 >3DLS-A nrPDB Length = 335 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 66/293 (22%), Positives = 114/293 (38%), Gaps = 42/293 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGV------PSTAIREISLL 55 + + + +G G +G V+ A +K + V +K I+ + E EI++L Sbjct: 24 QKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAIL 83 Query: 56 KELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 + H NI+K+LD+ + LV E L F + PL QL+ + Sbjct: 84 SRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAV 143 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175 + ++HRD+K +N++I + IKL DFG A YT T+ Y APE+L+ Sbjct: 144 GYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYT-FCGTIEYCAPEVLM 202 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 G Y +++WSLG +V F +L P + Sbjct: 203 GNPYRGPELEMWSLGVTLYTLVFEENPFC------ELEETVEAAIHPPYL---------- 246 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + ++ SL+S +L P +R + + + P+ Sbjct: 247 -------------------VSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ 280 >5O0Y-A nrPDB Length = 579 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 75/305 (24%), Positives = 121/305 (39%), Gaps = 53/305 (17%) Query: 15 YGVVYKARNKLTGEVVALKKIRL-----DTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 + VYKA + VA+K +L D + E A RE + KEL+HP IVKL D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 70 IH-TENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR--VLH 125 + V E+ DL ++ L + +S + Q++ L + + + ++H Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKL--MSEKEARSIIMQIVNALKYLNEIKPPIIH 414 Query: 126 RDLKPQNLLINTE---GAIKLADFGLARAFGVP-------VRTYTHEVVTLWYRAPEIL- 174 DLKP N+L+ G IK+ DFGL++ + + T WY PE Sbjct: 415 YDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFV 474 Query: 175 --LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 S VD+WS+G IF + + R F G ++ Q T+ EV +P Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQDILQENTILKATEVQFPP--- 530 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292 P + + ++ + + L Y RI + P+ Sbjct: 531 -------------------KPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL------ 565 Query: 293 VPHLR 297 +PH+R Sbjct: 566 LPHIR 570 >3CJF-A nrPDB Length = 309 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 119/303 (39%), Gaps = 50/303 (16%) Query: 2 ENFQKVEKIGEGTYGVVYKA----RNK-LTGEVVALKKIRLDTETEGVPSTAIREISLLK 56 + + +G G +G V +A +K T VA+K ++ + T + E+ +L Sbjct: 27 DRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-EGATHSEHRALMSELKILI 85 Query: 57 ELNHP-NIVKLLDVIHTEN-KLYLVFEFLH-QDLKKFMDASALTGIP----------LPL 103 + H N+V LL L ++ EF +L ++ + +P L Sbjct: 86 HIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEH 145 Query: 104 IKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTH 161 + Y FQ+ +G+ F S + +HRDL +N+L++ + +K+ DFGLAR Sbjct: 146 LICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGD 205 Query: 162 EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLG 220 + L + APE + + Y+ D+WS G + E+ + + +PG + R L Sbjct: 206 ARLPLKWMAPETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDE---EFCRRLK 261 Query: 221 TPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA 280 + P T+ Y+ W +P++R + Sbjct: 262 EGTRMRAPDYTTPEMYQTMLDCWHG------------------------EPSQRPTFSEL 297 Query: 281 LAH 283 + H Sbjct: 298 VEH 300 >3ZBF-A nrPDB Length = 322 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 65/274 (23%), Positives = 117/274 (42%), Gaps = 31/274 (11%) Query: 2 ENFQKVEKIGEGTYGVVYKAR-----NKLTGEV-VALKKIRLDTETEGVPSTAIREISLL 55 E +G G +G VY+ +GE+ VA+K ++ + T+ ++E L+ Sbjct: 33 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGS-TDQEKIEFLKEAHLM 91 Query: 56 KELNHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLP-----LIKSYLF 109 + NHPNI+K L V Y++ E + DL ++ + + P + Sbjct: 92 SKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCV 151 Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLI-----NTEGAIKLADFGLARAF--GVPVRTYTHE 162 + +G + +HRDL +N L+ + +K+ DFGLAR R Sbjct: 152 DISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEG 211 Query: 163 VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLF------RI 215 ++ + + APE L+ ++T D+WS G + E++T +P S +D L R+ Sbjct: 212 LLPVRWMAPESLMD-GIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRL 270 Query: 216 FRTLGTPDE---VVWPGVTSMPDYKPSFPKWARQ 246 PD+ ++ PD +P+F + Q Sbjct: 271 EPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQ 304 >3LZB-A nrPDB Length = 327 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 61/272 (22%), Positives = 122/272 (44%), Gaps = 21/272 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVV----ALKKIRLDTETEGVPSTAIREISLLKEL 58 F+K++ +G G +G VYK GE V A+K++R T + + E ++ + Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE-ILDEAYVMASV 74 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 ++P++ +LL + T + L+ + + L ++ I + ++ Q+ +G+ + Sbjct: 75 DNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDN-IGSQYLLNWCVQIAKGMNY 132 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--TLWYRAPEILL 175 R++HRDL +N+L+ T +K+ DFGLA+ G + Y E + + A E +L Sbjct: 133 LEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL 192 Query: 176 GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 + Y+ D+WS G E++T + G + I L + + P + ++ Sbjct: 193 -HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASE----ISSILEKGERLPQPPICTID 247 Query: 235 DYKPSFPKW-----ARQDFSKVVPPLDEDGRS 261 Y W +R F +++ + R Sbjct: 248 VYMIMRKCWMIDADSRPKFRELIIEFSKMARD 279 >4M7I-A nrPDB Length = 299 Score = 197 bits (501), Expect = 5e-51, Method: Composition-based stats. Identities = 78/318 (24%), Positives = 130/318 (40%), Gaps = 58/318 (18%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 + +F+ ++ +G G +GVV++A+NK+ A+K+IRL E +RE+ L +L H Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNR-ELAREKVMREVKALAKLEH 62 Query: 61 PNIVKLLDVIHTEN------------KLYLVFEFLHQ-DLKKFMD-ASALTGIPLPLIKS 106 P IV+ + +N LY+ + + +LK +M+ + + Sbjct: 63 PGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLH 122 Query: 107 YLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT-------- 158 Q+ + + F HS ++HRDLKP N+ + +K+ DFGL A Sbjct: 123 IFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 182 Query: 159 ----YTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR 214 +T +V T Y +PE + G YS VDI+SLG I E++ F E + Sbjct: 183 AYARHTGQVGTKLYMSPEQIHG-NSYSHKVDIFSLGLILFELL---YPFSTQMERVRTLT 238 Query: 215 IFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 274 R L P P + +P + ML P +R Sbjct: 239 DVRNLKFP-----------PLFTQKYPCEYVM----------------VQDMLSPSPMER 271 Query: 275 ISAKAALAHPFFQDVTKP 292 A + + F+D+ P Sbjct: 272 PEAINIIENAVFEDLDFP 289 >5TUR-A nrPDB Length = 404 Score = 196 bits (500), Expect = 6e-51, Method: Composition-based stats. Identities = 74/305 (24%), Positives = 122/305 (40%), Gaps = 48/305 (15%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP----STAIREISLLKEL 58 +Q +G G +G VY VA+K + D ++ + E+ LLK++ Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 187 Query: 59 NHPN--IVKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 + +++LLD + L+ E QDL F+ + L +S+ +Q+L+ Sbjct: 188 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA--LQEELARSFFWQVLEA 245 Query: 115 LAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 173 + CH+ VLHRD+K +N+LI+ G +KL DFG V YT T Y PE Sbjct: 246 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEW 303 Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233 + +Y+ + +WSLG + +MV F D EI + FR Sbjct: 304 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ--------------- 348 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293 + + + L+ L P+ R + + HP+ QDV P Sbjct: 349 --------------------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 388 Query: 294 PHLRL 298 + Sbjct: 389 ETAEI 393 >2X7G-A nrPDB Length = 389 Score = 196 bits (499), Expect = 9e-51, Method: Composition-based stats. Identities = 90/365 (24%), Positives = 143/365 (39%), Gaps = 86/365 (23%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN--- 59 + + K+G G + V+ + VA+K ++ + TA+ EI LLK + Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK---SAQHYTETALDEIKLLKCVRESD 88 Query: 60 --HPN---IVKLLDVIHTEN----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ 110 PN +V+L+D + +VFE L L K++ S G+P+ +KS + Q Sbjct: 89 PSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQ 148 Query: 111 LLQGLAFCHSH-RVLHRDLKPQNLLINTEG------------------------------ 139 +LQGL + HS +++H D+KP+N+L+ + Sbjct: 149 VLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAP 208 Query: 140 -----------------AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182 +K+AD G A + +T ++ T YR+ E+L+G YST Sbjct: 209 AADLLVNPLDPRNADKIRVKIADLGNACWVH---KHFTEDIQTRQYRSIEVLIGAG-YST 264 Query: 183 AVDIWSLGCIFAEMVTRRALFPGDS------EIDQLFRIFRTLGT-PDEVVWPGVTSMPD 235 DIWS C+ E+ T LF S + D + I LG+ P G S Sbjct: 265 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREF 324 Query: 236 YK--------PSFPKWARQD--FSKVVPPLDEDGR--SLLSQMLHYDPNKRISAKAALAH 283 + W+ D K P ++ + L ML P KR SA L H Sbjct: 325 FNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRH 384 Query: 284 PFFQD 288 P+ Sbjct: 385 PWLNS 389 >3PP0-A nrPDB Length = 338 Score = 196 bits (499), Expect = 9e-51, Method: Composition-based stats. Identities = 59/272 (21%), Positives = 117/272 (43%), Gaps = 21/272 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVV----ALKKIRLDTETEGVPSTAIREISLLKEL 58 +KV+ +G G +G VYK GE V A+K +R +T + + E ++ + Sbjct: 18 ELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKE-ILDEAYVMAGV 76 Query: 59 NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 P + +LL + T + LV + + + L + + + + ++ Q+ +G+++ Sbjct: 77 GSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGR-LGSQDLLNWCMQIAKGMSY 134 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--TLWYRAPEILL 175 R++HRDL +N+L+ + +K+ DFGLAR + Y + + + A E +L Sbjct: 135 LEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESIL 194 Query: 176 GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 + ++ D+WS G E++T + G + I L + + P + ++ Sbjct: 195 -RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPARE----IPDLLEKGERLPQPPICTID 249 Query: 235 DYKPSFPKWA-----RQDFSKVVPPLDEDGRS 261 Y W R F ++V R Sbjct: 250 VYMIMVKCWMIDSECRPRFRELVSEFSRMARD 281 >4HZS-A nrPDB Length = 341 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 69/258 (26%), Positives = 121/258 (46%), Gaps = 22/258 (8%) Query: 2 ENFQKVEKIGEGTYGVVYKAR-NKLTGEVV--ALKKIRLDTETE-GVPSTAIREISLLKE 57 ++ + +EK+G+G++GVV + + +G+ V A+K ++ D ++ IRE++ + Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 71 Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 L+H N+++L V+ T + +V E L + + L + Y Q+ +G+ Sbjct: 72 LDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEGMG 129 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT---HEVVTLWYRAPEI 173 + S R +HRDL +NLL+ T +K+ DFGL RA Y H V + APE Sbjct: 130 YLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPES 189 Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRI---FRTLGTPDE----- 224 L + +S A D W G EM T + + G + L +I L P++ Sbjct: 190 LK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI 248 Query: 225 --VVWPGVTSMPDYKPSF 240 V+ P+ +P+F Sbjct: 249 YNVMVQCWAHKPEDRPTF 266 >2W1I-A nrPDB Length = 326 Score = 195 bits (497), Expect = 1e-50, Method: Composition-based stats. Identities = 72/291 (24%), Positives = 129/291 (44%), Gaps = 32/291 (10%) Query: 3 NFQKVEKIGEGTYGVVYKARNKL----TGEVVALKKIRLDTETEGVPSTAIREISLLKEL 58 + + ++++G+G +G V R TGEVVA+KK++ TE REI +LK L Sbjct: 42 HLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH--STEEHLRDFEREIEILKSL 99 Query: 59 NHPNIVKLLDVIHTENK--LYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 H NIVK V ++ + L L+ E+L + L+ ++ I + Y Q+ +G+ Sbjct: 100 QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK-ERIDHIKLLQYTSQICKGM 158 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV---TLWYRAPE 172 + + R +HRDL +N+L+ E +K+ DFGL + Y + +++ APE Sbjct: 159 EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPE 218 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 L K +S A D+WS G + E+ T I ++ P E + Sbjct: 219 SLTESK-FSVASDVWSFGVVLYELFTY---------------IEKSKSPPAEFMRMIGND 262 Query: 233 MPDYKPSFPKWARQDFSKVVPPLD---EDGRSLLSQMLHYDPNKRISAKAA 280 F + +P D ++ ++++ + + N+R S + Sbjct: 263 KQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 313 >5HVK-A nrPDB Length = 315 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 64/302 (21%), Positives = 124/302 (41%), Gaps = 45/302 (14%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + E +G+G +G K ++ TGEV+ +K++ E T ++E+ +++ L HPN Sbjct: 15 DLIHGEVLGKGCFGQAIKVTHRETGEVMVMKEL--IRFDEETQRTFLKEVKVMRCLEHPN 72 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 ++K + V++ + +L + E++ + + S + P S+ + G+A+ HS Sbjct: 73 VLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMN 132 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAF--------------GVPVRTYTHEVVTLWY 168 ++HR+L N L+ + +ADFGLAR + V ++ Sbjct: 133 IIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYW 192 Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228 APE++ G + Y VD++S G + E+ I R PD + Sbjct: 193 MAPEMING-RSYDEKVDVFSFGIVLCEI------------------IGRVNADPDYLPRT 233 Query: 229 GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288 + + + ++ + P+ L DP KR S L H + + Sbjct: 234 MDFGL-NVRGFLDRYCPPNCPPSFFPITVRCCDL-------DPEKRPSFVK-LEH-WLET 283 Query: 289 VT 290 + Sbjct: 284 LR 285 >5GRN-A nrPDB Length = 356 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 60/283 (21%), Positives = 110/283 (38%), Gaps = 46/283 (16%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGE-----VVALKKIRLDTETEGVPSTAIREISLLK 56 + +G G +G V + VA+K ++ T + E+ ++ Sbjct: 46 DGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLK-PTARSSEKQALMSELKIMT 104 Query: 57 ELN-HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASAL------------------ 96 L H NIV LL +Y++ E+ + DL ++ + Sbjct: 105 HLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNL 164 Query: 97 ------TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLAR 150 G+ L + S+ +Q+ +G+ F S +HRDL +N+L+ +K+ DFGLAR Sbjct: 165 LSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLAR 224 Query: 151 AFGVPVR--TYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDS 207 + + + + APE + Y+T D+WS G + E+ + +PG Sbjct: 225 DIMHDSNYVSKGSTFLPVKWMAPESIFD-NLYTTLSDVWSYGILLWEIFSLGGTPYPGMM 283 Query: 208 EIDQLFRIFR---TLGTPD-------EVVWPGVTSMPDYKPSF 240 + + + PD E++ S P+ +PSF Sbjct: 284 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSF 326 >4LFI-A nrPDB Length = 374 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 77/340 (22%), Positives = 151/340 (44%), Gaps = 51/340 (15%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVAL------------------------KKIRL 37 ++++ K+G G Y V++ + + + K Sbjct: 40 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 99 Query: 38 DTETEGVPSTAIREISLLKELN----------HPNIVKLLDVIHTE--NKLYLVFEFLHQ 85 + ++ +LK + H NI+ L D+I LVFE++ Sbjct: 100 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 159 Query: 86 DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT-EGAIKLA 144 + + + I+ Y+F+LL+ L +CHS ++HRD+KP N++I+ ++L Sbjct: 160 VDFRIL----YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 215 Query: 145 DFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRAL-F 203 D+GLA + V + Y V + +++ PE+L+ + Y ++D+WS G + A M+ +R F Sbjct: 216 DWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF 274 Query: 204 PGDSEIDQLFRIFRTLGTPDEVVWPGVTS--MPDYKPSFPKWARQDFSKVV------PPL 255 G S DQL +I + LGT D + +P ++ R+ + + + Sbjct: 275 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSG 334 Query: 256 DEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPH 295 +++ L+ +L YD +R++AK A+ HP+F + + + Sbjct: 335 NDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 374 >3BGP-A nrPDB Length = 333 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 74/305 (24%), Positives = 122/305 (40%), Gaps = 48/305 (15%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP----STAIREISLLKEL 58 +Q +G G +G VY VA+K + D ++ + E+ LLK++ Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 116 Query: 59 NHPN--IVKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 + +++LLD + L+ E QDL F+ + L +S+ +Q+L+ Sbjct: 117 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA--LQEELARSFFWQVLEA 174 Query: 115 LAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 173 + CH+ VLHRD+K +N+LI+ G +KL DFG V YT T Y PE Sbjct: 175 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEW 232 Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233 + +Y+ + +WSLG + +MV F D EI + FR Sbjct: 233 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ--------------- 277 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293 + + + L+ L P+ R + + HP+ QDV P Sbjct: 278 --------------------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 317 Query: 294 PHLRL 298 + Sbjct: 318 ETAEI 322 >5U6B-A nrPDB Length = 307 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 64/279 (22%), Positives = 123/279 (44%), Gaps = 28/279 (10%) Query: 6 KVEKIGEGTYGVVYKARNKLTG--EVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 + +GEG +G V + + VA+K +++ T + E +KE +HPN+ Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 64 VKLLDVIHTENKL------YLVFEFL-HQDLKKFMDASALTG----IPLPLIKSYLFQLL 112 ++L+ V ++ ++ F+ H DL F+ S L +P ++ ++ + Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--TLWYRA 170 G+ + + R +HRDL +N ++N ++ +ADFGL++ + + + A Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIA 206 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPG--DSEIDQLFRIFRTLGTPDE--- 224 E L + Y++ D+WS G E+ T + +PG +SEI R L P + Sbjct: 207 IESLAD-RVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLD 265 Query: 225 ----VVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDE 257 ++ P +PSF + ++ K +PP E Sbjct: 266 GLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQE 304 >3M42-A nrPDB Length = 299 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 63/301 (20%), Positives = 111/301 (36%), Gaps = 61/301 (20%) Query: 1 MENFQKV-EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLL-KEL 58 +++++ + +G G G V + NK T E ALK + A RE+ L + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 68 Query: 59 NHPNIVKLLDVIHT----ENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQ 113 P+IV+++DV L +V E L L + + + + Sbjct: 69 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 128 Query: 114 GLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170 + + HS + HRD+KP+NLL + +KL DFG A+ Sbjct: 129 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE------------------- 169 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230 + Y + D+WSLG I ++ F + G Sbjct: 170 ----TTGEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMKTR 213 Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 M Y+ P+W+ + E+ + L+ +L +P +R++ + HP+ T Sbjct: 214 IRMGQYEFPNPEWS---------EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 264 Query: 291 K 291 K Sbjct: 265 K 265 >3IO7-A nrPDB Length = 313 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 72/291 (24%), Positives = 129/291 (44%), Gaps = 32/291 (10%) Query: 3 NFQKVEKIGEGTYGVVYKARNKL----TGEVVALKKIRLDTETEGVPSTAIREISLLKEL 58 + + ++++G+G +G V R TGEVVA+KK++ TE REI +LK L Sbjct: 29 HLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH--STEEHLRDFEREIEILKSL 86 Query: 59 NHPNIVKLLDVIHTENK--LYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 H NIVK V ++ + L L+ E+L + L+ ++ I + Y Q+ +G+ Sbjct: 87 QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK-ERIDHIKLLQYTSQICKGM 145 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV---TLWYRAPE 172 + + R +HRDL +N+L+ E +K+ DFGL + Y + +++ APE Sbjct: 146 EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPE 205 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 L K +S A D+WS G + E+ T I ++ P E + Sbjct: 206 SLTESK-FSVASDVWSFGVVLYELFTY---------------IEKSKSPPAEFMRMIGND 249 Query: 233 MPDYKPSFPKWARQDFSKVVPPLD---EDGRSLLSQMLHYDPNKRISAKAA 280 F + +P D ++ ++++ + + N+R S + Sbjct: 250 KQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >1U59-A nrPDB Length = 287 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 64/265 (24%), Positives = 116/265 (43%), Gaps = 12/265 (4%) Query: 9 KIGEGTYGVVYKARNKLTGEV--VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 ++G G +G V + ++ + VA+K ++ TE + +RE ++ +L++P IV+L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVRL 75 Query: 67 LDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 125 + V E L LV E L KF+ IP+ + L Q+ G+ + +H Sbjct: 76 IGVCQAE-ALMLVMEMAGGGPLHKFL-VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 133 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILLGCKYYST 182 RDL +N+L+ K++DFGL++A G YT W + APE + + +S+ Sbjct: 134 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFSS 192 Query: 183 AVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-PDEVVWPGVTSMPDYKPSF 240 D+WS G E ++ + + + + I + P + ++ + Sbjct: 193 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIY 252 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQ 265 R DF V + SL S+ Sbjct: 253 KWEDRPDFLTVEQRMRACYYSLASK 277 >4RC3-A nrPDB Length = 289 Score = 194 bits (494), Expect = 3e-50, Method: Composition-based stats. Identities = 74/305 (24%), Positives = 122/305 (40%), Gaps = 48/305 (15%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP----STAIREISLLKEL 58 +Q +G G +G VY VA+K + D ++ + E+ LLK++ Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 72 Query: 59 NHPN--IVKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 + +++LLD + L+ E QDL F+ + L +S+ +Q+L+ Sbjct: 73 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA--LQEELARSFFWQVLEA 130 Query: 115 LAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 173 + CH+ VLHRD+K +N+LI+ G +KL DFG V YT T Y PE Sbjct: 131 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEW 188 Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233 + +Y+ + +WSLG + +MV F D EI + FR Sbjct: 189 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ--------------- 233 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293 + + + L+ L P+ R + + HP+ QDV P Sbjct: 234 --------------------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 273 Query: 294 PHLRL 298 + Sbjct: 274 ETAEI 278 >2OZO-A nrPDB Length = 613 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 63/265 (23%), Positives = 116/265 (43%), Gaps = 12/265 (4%) Query: 9 KIGEGTYGVVYKARNKLTGEV--VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66 ++G G +G V + ++ + VA+K ++ TE + +RE ++ +L++P IV+L Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVRL 401 Query: 67 LDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 125 + V E L LV E L KF+ IP+ + L Q+ G+ + +H Sbjct: 402 IGVCQAE-ALMLVMEMAGGGPLHKFL-VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 Query: 126 RDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILLGCKYYST 182 R+L +N+L+ K++DFGL++A G YT W + APE + + +S+ Sbjct: 460 RNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFSS 518 Query: 183 AVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGT-PDEVVWPGVTSMPDYKPSF 240 D+WS G E ++ + + + + I + P + ++ + Sbjct: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIY 578 Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQ 265 R DF V + SL S+ Sbjct: 579 KWEDRPDFLTVEQRMRACYYSLASK 603 >1U54-B nrPDB Length = 291 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 69/258 (26%), Positives = 121/258 (46%), Gaps = 22/258 (8%) Query: 2 ENFQKVEKIGEGTYGVVYKAR-NKLTGEVV--ALKKIRLDTETE-GVPSTAIREISLLKE 57 ++ + +EK+G+G++GVV + + +G+ V A+K ++ D ++ IRE++ + Sbjct: 18 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 77 Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 L+H N+++L V+ T + +V E L + + L + Y Q+ +G+ Sbjct: 78 LDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEGMG 135 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT---HEVVTLWYRAPEI 173 + S R +HRDL +NLL+ T +K+ DFGL RA Y H V + APE Sbjct: 136 YLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPES 195 Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRI---FRTLGTPDE----- 224 L + +S A D W G EM T + + G + L +I L P++ Sbjct: 196 LK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI 254 Query: 225 --VVWPGVTSMPDYKPSF 240 V+ P+ +P+F Sbjct: 255 YNVMVQCWAHKPEDRPTF 272 >4WUA-A nrPDB Length = 401 Score = 194 bits (493), Expect = 4e-50, Method: Composition-based stats. Identities = 86/367 (23%), Positives = 140/367 (38%), Gaps = 88/367 (23%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL---- 58 + + K+G G + V+ + + + VA+K ++ E TA+ EI LLK + Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK---SAEHYTETALDEIRLLKSVRNSD 98 Query: 59 -NHPN---IVKLLDVIH----TENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ 110 N PN +V+LLD + +VFE L L K++ S G+PLP +K + Q Sbjct: 99 PNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQ 158 Query: 111 LLQGLAFCHSH-RVLHRDLKPQNLLIN--------------------------------- 136 +LQGL + H+ R++H D+KP+N+L++ Sbjct: 159 VLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAP 218 Query: 137 ----------------TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180 + +K+AD G A + +T ++ T YR+ E+L+G Y Sbjct: 219 ATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH---KHFTEDIQTRQYRSLEVLIGSG-Y 274 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDS------EIDQLFRIFRTLGTPDEVVWPGVTSMP 234 +T DIWS C+ E+ T LF S + D + I LG + Sbjct: 275 NTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSK 334 Query: 235 DYKPSFPKWARQD----------FSKVVPPLDEDGR---SLLSQMLHYDPNKRISAKAAL 281 ++ + E+ L ML P KR +A L Sbjct: 335 EFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECL 394 Query: 282 AHPFFQD 288 HP+ Sbjct: 395 RHPWLNS 401 >2A1A-B nrPDB Length = 284 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 63/297 (21%), Positives = 122/297 (41%), Gaps = 58/297 (19%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 +F+++E IG G +G V+KA++++ G+ +K+++ + E A RE+ L +L+H N Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEK------AEREVKALAKLDHVN 65 Query: 63 IVKLLDVI----------------HTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIK 105 IV L++ EF L+++++ + L Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLAL 125 Query: 106 SYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT 165 Q+ +G+ + HS ++++RDLKP N+ + +K+ DFGL + + T T Sbjct: 126 ELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGK-RTRSKGT 184 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEV 225 L Y +PE + + Y VD+++LG I AE++ D F + + Sbjct: 185 LRYMSPEQI-SSQDYGKEVDLYALGLILAELL---------HVCDTAFETSKFFTDLRDG 234 Query: 226 VWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 282 + + + ++LL ++L P R + L Sbjct: 235 IISDIFDKKE------------------------KTLLQKLLSKKPEDRPNTSEILR 267 >4LRM-A nrPDB Length = 334 Score = 193 bits (492), Expect = 6e-50, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 122/275 (44%), Gaps = 24/275 (8%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVV----ALKKIRLDTETEGVPSTAIREISLLKEL 58 F+K++ +G G +G VYK GE V A+K++R T + + E ++ + Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE-ILDEAYVMASV 78 Query: 59 NHP---NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 ++P ++ +LL + T + L+ + + L ++ I + ++ Q+ +G Sbjct: 79 DNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDN-IGSQYLLNWCVQIAKG 136 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--TLWYRAPE 172 + + R++HRDL +N+L+ T +K+ DFGLA+ G + Y E + + A E Sbjct: 137 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALE 196 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT 231 +L + Y+ D+WS G E++T + G + I L + + P + Sbjct: 197 SIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASE----ISSILEKGERLPQPPIC 251 Query: 232 SMPDYKPSFPKW-----ARQDFSKVVPPLDEDGRS 261 ++ Y W +R F +++ + R Sbjct: 252 TIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARD 286 >3C1X-A nrPDB Length = 373 Score = 193 bits (492), Expect = 6e-50, Method: Composition-based stats. Identities = 69/258 (26%), Positives = 118/258 (45%), Gaps = 22/258 (8%) Query: 8 EKIGEGTYGVVYKAR---NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64 E IG G +G VY N A+K + T+ G S + E ++K+ +HPN++ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDI-GEVSQFLTEGIIMKDFSHPNVL 153 Query: 65 KLLDVI-HTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 LL + +E +V ++ H DL+ F+ LI + Q+ +G+ F S + Sbjct: 154 SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLI-GFGLQVAKGMKFLASKK 212 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFG----VPVRTYTHEVVTLWYRAPEILLGCK 178 +HRDL +N +++ + +K+ADFGLAR V T + + + A E L K Sbjct: 213 FVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQK 272 Query: 179 YYSTAVDIWSLGCIFAEMVT-RRALFPGDSEID------QLFRIFRTLGTPD---EVVWP 228 ++T D+WS G + E++T +P + D Q R+ + PD EV+ Sbjct: 273 -FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLK 331 Query: 229 GVTSMPDYKPSFPKWARQ 246 + +PSF + + Sbjct: 332 CWHPKAEMRPSFSELVSR 349 >5HLW-A nrPDB Length = 299 Score = 193 bits (491), Expect = 7e-50, Method: Composition-based stats. Identities = 68/258 (26%), Positives = 118/258 (45%), Gaps = 22/258 (8%) Query: 8 EKIGEGTYGVVYKAR---NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64 E IG G +G VY N A+K + T+ G S + E ++K+ +HPN++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDI-GEVSQFLTEGIIMKDFSHPNVL 84 Query: 65 KLLDVI-HTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 LL + +E +V ++ H DL+ F+ LI + Q+ +G+ + S + Sbjct: 85 SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLI-GFGLQVAKGMKYLASKK 143 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGV----PVRTYTHEVVTLWYRAPEILLGCK 178 +HRDL +N +++ + +K+ADFGLAR V T + + + A E L K Sbjct: 144 FVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQK 203 Query: 179 YYSTAVDIWSLGCIFAEMVT-RRALFPGDSEID------QLFRIFRTLGTPD---EVVWP 228 ++T D+WS G + E++T +P + D Q R+ + PD EV+ Sbjct: 204 -FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLK 262 Query: 229 GVTSMPDYKPSFPKWARQ 246 + +PSF + + Sbjct: 263 CWHPKAEMRPSFSELVSR 280 >5TQX-A nrPDB Length = 655 Score = 193 bits (490), Expect = 9e-50, Method: Composition-based stats. Identities = 75/281 (26%), Positives = 125/281 (44%), Gaps = 18/281 (6%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 ++ E++G G +G V +++ +A+K RL+ T+ EI ++K+LNH N+ Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKN-RERWCHEIQIMKKLNHANV 68 Query: 64 VKLLDVIHTENKL-----YLVFEFL-HQDLKKFMDA-SALTGIPLPLIKSYLFQLLQGLA 116 VK DV N L L E+ DL+K ++ G+ I S L + G+ Sbjct: 69 VKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIR 128 Query: 117 FCHSHRVLHRDLKPQNLLI-NTEGAI--KLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 173 + H ++++HRDLKP+N+++ + G I K+ D G A+ T V TL Y APE Sbjct: 129 YLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQG-ELCTEFVGTLQYLAPE- 186 Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233 L K Y+ VD WS G + E + F + + ++ Sbjct: 187 LFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGE 246 Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 274 + P+ S +V P++ L ML++DP +R Sbjct: 247 VRFSSHLPQ-PNSLCSLIVEPMENW----LQLMLNWDPQQR 282 >4HVI-A nrPDB Length = 314 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 68/284 (23%), Positives = 115/284 (40%), Gaps = 27/284 (9%) Query: 3 NFQKVEKIGEGTYGVVYKARNKL----TGEVVALKKIRLDTETEGVPSTAIREISLLKEL 58 + + + ++G+G +G V R TG +VA+K+++ + REI +LK L Sbjct: 11 HLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQ--RDFQREIQILKAL 68 Query: 59 NHPNIVKLLDVIHTENK--LYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 + IVK V + + L LV E+L L+ F+ + + Y Q+ +G+ Sbjct: 69 HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR-LDASRLLLYSSQICKGM 127 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV---TLWYRAPE 172 + S R +HRDL +N+L+ +E +K+ADFGLA+ + Y +++ APE Sbjct: 128 EYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPE 187 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 L +S D+WS G + E+ T D R +G+ +V Sbjct: 188 SLSD-NIFSRQSDVWSFGVVLYELFTYC-----DKSCSPSAEFLRMMGSERDV------- 234 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS 276 P P + L+ P R S Sbjct: 235 -PALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPS 277 >3I81-A nrPDB Length = 315 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 58/282 (20%), Positives = 117/282 (41%), Gaps = 28/282 (9%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGE-----VVALKKIRLDTETEGVPSTAIREISLLK 56 E ++G+G++G+VY+ K + VA+K + + + + E S++K Sbjct: 18 EKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAASMRERIEFLNEASVMK 76 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALT--------GIPLPLIKSY 107 E N ++V+LL V+ ++ E + DLK ++ + L + Sbjct: 77 EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQM 136 Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--T 165 ++ G+A+ ++++ +HRDL +N ++ + +K+ DFG+ R Sbjct: 137 AGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLP 196 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTR-RALFPGDSEIDQLFRIF------RT 218 + + +PE L ++T D+WS G + E+ T + G S L + + Sbjct: 197 VRWMSPESLKD-GVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKP 255 Query: 219 LGTPD---EVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDE 257 PD E++ P +PSF + ++ P E Sbjct: 256 DNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFRE 297 >3G0E-A nrPDB Length = 336 Score = 191 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 114/307 (37%), Gaps = 55/307 (17%) Query: 2 ENFQKVEKIGEGTYGVVYKAR-----NKLTGEVVALKKIRLDTETEGVPSTAIREISLLK 56 + +G G +G V +A VA+K ++ + + E+ +L Sbjct: 46 NRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK-PSAHLTEREALMSELKVLS 104 Query: 57 EL-NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGI--------------- 99 L NH NIV LL ++ E+ + DL F+ + I Sbjct: 105 YLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELA 164 Query: 100 -PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT 158 L + S+ +Q+ +G+AF S +HRDL +N+L+ K+ DFGLAR Sbjct: 165 LDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNY 224 Query: 159 --YTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRI 215 + + + + APE + C Y+ D+WS G E+ + + +PG + +++ Sbjct: 225 VVKGNARLPVKWMAPESIFNC-VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKM 283 Query: 216 FRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI 275 + ++ P+ A + ++ DP KR Sbjct: 284 IK----------------EGFRMLSPEHAP-----------AEMYDIMKTCWDADPLKRP 316 Query: 276 SAKAALA 282 + K + Sbjct: 317 TFKQIVQ 323 >5UIU-A nrPDB Length = 323 Score = 191 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 59/199 (29%), Positives = 94/199 (47%), Gaps = 10/199 (5%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKI--RLDTETEGVPSTAIREISLLKELNHPNIVKL 66 K+GEG +GVVYK + VA+KK+ +D TE + +EI ++ + H N+V+L Sbjct: 54 KMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 67 LDVIHTENKLYLVFEFLHQD--LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 L + L LV+ ++ L + + + G+ F H + + Sbjct: 112 LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHI 171 Query: 125 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE--VVTLWYRAPEILLGCKYYST 182 HRD+K N+L++ K++DFGLARA +T V T Y APE L G + Sbjct: 172 HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE--ITP 229 Query: 183 AVDIWSLGCIFAEMVTRRA 201 DI+S G + E++T Sbjct: 230 KSDIYSFGVVLLEIITGLP 248 >2RIO-A nrPDB Length = 434 Score = 191 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 80/319 (25%), Positives = 142/319 (44%), Gaps = 60/319 (18%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVKL 66 + +G G+ G V + G VA+K++ +D A+ EI LL E + HPN+++ Sbjct: 21 KILGYGSSGTVVF-QGSFQGRPVAVKRMLID-----FCDIALMEIKLLTESDDHPNVIRY 74 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSY-----LFQLLQGLAFCHSH 121 T+ LY+ E + +L+ +++ ++ L L K Y L Q+ G+A HS Sbjct: 75 YCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSL 134 Query: 122 RVLHRDLKPQNLLIN-------------TEGAIKLADFGLARAFGVPVRTYTHEV----V 164 +++HRDLKPQN+L++ I ++DFGL + ++ + Sbjct: 135 KIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSG 194 Query: 165 TLWYRAPEILLGC------KYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFR 217 T +RAPE+L + + ++DI+S+GC+F +++ + F + + I R Sbjct: 195 TSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF--GDKYSRESNIIR 252 Query: 218 TLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA 277 + + DE+ L + L+SQM+ +DP KR +A Sbjct: 253 GIFSLDEMKC----------------------LHDRSLIAEATDLISQMIDHDPLKRPTA 290 Query: 278 KAALAHPFFQDVTKPVPHL 296 L HP F +K + L Sbjct: 291 MKVLRHPLFWPKSKKLEFL 309 >3QUP-A nrPDB Length = 323 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 118/292 (40%), Gaps = 46/292 (15%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTG---EVVALKKIRLDTETEGVPSTAIREISLLKEL 58 + F +G+G +G V +A+ K VA+K ++ D +RE + +KE Sbjct: 23 QQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEF 82 Query: 59 NHPNIVKLLDVIHT---ENKL---YLVFEFL-HQDLKKFMDASALTG----IPLPLIKSY 107 +HP++ KL+ V + +L ++ F+ H DL F+ AS + +PL + + Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRF 142 Query: 108 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVT 165 + + G+ + S +HRDL +N ++ + + +ADFGL+R G R + Sbjct: 143 MVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLP 202 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDE 224 + + A E L Y+ D+W+ G E++T + + G + + Sbjct: 203 VKWLALESLAD-NLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLI-------- 253 Query: 225 VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS 276 + K P E+ L+ Q DP +R S Sbjct: 254 --------------------GGNRLKQPPECMEEVYDLMYQCWSADPKQRPS 285 >5TOS-A nrPDB Length = 395 Score = 190 bits (484), Expect = 5e-49, Method: Composition-based stats. Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 30/296 (10%) Query: 3 NFQKVEKIGEGTYGVVYKA---------RNKLTGEVVALKKIRLDTETEGVPSTAIREIS 53 NF+ IGEG +G V+K TG V+A+KK+ + + EI+ Sbjct: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLTEIN 123 Query: 54 LLKELNHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSY--LFQ 110 L +L+HPN+VKL+ + LV+EF+ L+ + PLP Sbjct: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 Query: 111 LLQGLAFCHSH--RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY--THEVVTL 166 +GLAF HS +V++RD+K N+L++ + KL+DFGLAR + +Y T + T Sbjct: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 Query: 167 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVV 226 Y APE + + + D++S G + E+++ + + +V Sbjct: 244 GYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKR-----------ALDHNRPAKEENLV 291 Query: 227 WPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 282 + + + ++ +P S+ Q L ++P R + + Sbjct: 292 DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 >4TPT-A nrPDB Length = 303 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 58/216 (26%), Positives = 104/216 (48%), Gaps = 26/216 (12%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + E +G+G +G K +K TG+V+ +K++ E T + E+ +++ L+HPN Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKEL--IRCDEETQKTFLTEVKVMRSLDHPN 58 Query: 63 IVKLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 ++K + V++ + KL L+ E++ LK F+ + + P + + G+A+ HS Sbjct: 59 VLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRS--MDPFPWQQKVRFAKGIASGMAYLHSM 116 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAF--------------------GVPVRTYTH 161 ++HRDL N LI + + +ADFGL+R + Sbjct: 117 CIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYT 176 Query: 162 EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMV 197 V ++ APE+L G K Y VDI+S G + E++ Sbjct: 177 VVGNPYWMAPEMLNG-KSYDETVDIFSFGIVLCEII 211 >3UIU-A nrPDB Length = 306 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 122/310 (39%), Gaps = 71/310 (22%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 +F+++E IG G +G V+KA++++ G+ +++++ + E A RE+ L +L+H N Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEK------AEREVKALAKLDHVN 66 Query: 63 IVKLLDVI-----------------------------HTENKLYLVFEFLH-QDLKKFMD 92 IV L++ EF L+++++ Sbjct: 67 IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIE 126 Query: 93 ASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF 152 + L Q+ +G+ + HS +++HRDLKP N+ + +K+ DFGL + Sbjct: 127 KRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 186 Query: 153 GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQL 212 + T TL Y +PE + + Y VD+++LG I AE++ D Sbjct: 187 KNDGK-RTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL---------HVCDTA 235 Query: 213 FRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPN 272 F + + + + + ++LL ++L P Sbjct: 236 FETSKFFTDLRDGIISDIFDKKE------------------------KTLLQKLLSKKPE 271 Query: 273 KRISAKAALA 282 R + L Sbjct: 272 DRPNTSEILR 281 >5U6C-A nrPDB Length = 315 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 58/260 (22%), Positives = 114/260 (43%), Gaps = 26/260 (10%) Query: 6 KVEKIGEGTYGVVYKARNKL---TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + +GEG +G V + K T VA+K ++LD ++ + E + +K+ +HPN Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPN 99 Query: 63 IVKLLDVIHTE-----NKLYLVFEFL-HQDLKKFMDASALT----GIPLPLIKSYLFQLL 112 +++LL V K ++ F+ + DL ++ S L IPL + ++ + Sbjct: 100 VMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIA 159 Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--TLWYRA 170 G+ + + LHRDL +N ++ + + +ADFGL++ + + + A Sbjct: 160 LGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIA 219 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQ---------LFRIFRTLG 220 E L + Y++ D+W+ G E+ T +PG + L + L Sbjct: 220 IESLAD-RVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLD 278 Query: 221 TPDEVVWPGVTSMPDYKPSF 240 E+++ + P +P+F Sbjct: 279 ELYEIMYSCWRTDPLDRPTF 298 >3LLT-A nrPDB Length = 360 Score = 188 bits (478), Expect = 2e-48, Method: Composition-based stats. Identities = 73/331 (22%), Positives = 128/331 (38%), Gaps = 54/331 (16%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 F + K+G+GT+G V ++ + A+K +R + +A E +LK++ + +I Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVR---NIKKYTRSAKIEADILKKIQNDDI 93 Query: 64 -----VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 VK + + L+FE L L + + + G + IK Y ++L+ L + Sbjct: 94 NNNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYL 153 Query: 119 HSHRVLHRDLKPQNLLINT--------------EGA-----------IKLADFGLARAFG 153 + H DLKP+N+L++ +G IKL DFG A Sbjct: 154 RKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKS 213 Query: 154 VPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLF 213 + + T YRAPE++L + + D+WS GC+ AE+ T LF ++ L Sbjct: 214 D---YHGSIINTRQYRAPEVILNLG-WDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLA 269 Query: 214 RIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLD----------------- 256 + + + + T K + + + ++ Sbjct: 270 MMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKIIKH 329 Query: 257 EDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 E L +L DP R S L H F + Sbjct: 330 ELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >4PL5-B nrPDB Length = 435 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 80/302 (26%), Positives = 124/302 (41%), Gaps = 47/302 (15%) Query: 9 KIGEGTYGV-VYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVKL 66 +G G G VYK VA+K+I + S A RE+ LL+E + HPN+++ Sbjct: 34 VLGHGAEGTIVYKG--MFDNRDVAVKRILPE-----CFSFADREVQLLRESDEHPNVIRY 86 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 Y+ E L+++++ + L I + L Q GLA HS ++HR Sbjct: 87 FCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPI-TLLHQTTSGLAHLHSLNIVHR 145 Query: 127 DLKPQNLLI---NTEGAIK--LADFGLARAFGVPVRTYTHEVV---TLWYRAPEILLGCK 178 DLKP N+L+ N G IK ++DFGL + V +++ T + APE+L Sbjct: 146 DLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDC 205 Query: 179 YY--STAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 + VDI+S GC+F +++ F S+ Sbjct: 206 KDNPTYTVDIFSAGCVFYYVISEGYHPFG--------------------------KSLQR 239 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPH 295 D D R L+ +M+ DP +R SAK L HPFF + K + Sbjct: 240 QANILLGACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQF 299 Query: 296 LR 297 + Sbjct: 300 FQ 301 >6HV0-A nrPDB Length = 416 Score = 186 bits (474), Expect = 7e-48, Method: Composition-based stats. Identities = 85/302 (28%), Positives = 131/302 (43%), Gaps = 47/302 (15%) Query: 9 KIGEGTYGV-VYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVKL 66 +G G G VY+ VA+K+I + S A RE+ LL+E + HPN+++ Sbjct: 15 VLGHGAEGTIVYRG--MFDNRDVAVKRILPE-----CFSFADREVQLLRESDEHPNVIRY 67 Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 Y+ E L+++++ + L I + L Q GLA HS ++HR Sbjct: 68 FCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPI-TLLQQTTSGLAHLHSLNIVHR 126 Query: 127 DLKPQNLLI---NTEGAIK--LADFGLARAFGVPVRTYTHEVV---TLWYRAPEILLG-- 176 DLKP N+LI N G IK ++DFGL + V +++ T + APE+L Sbjct: 127 DLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDC 186 Query: 177 CKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 + + VDI+S GC+F +++ F G S Q + G S+ Sbjct: 187 KENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQ------------ANILLGACSLDC 233 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPH 295 P + D R L+ +M+ DP KR SAK L HPFF + K + Sbjct: 234 LHPEKHE-------------DVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQF 280 Query: 296 LR 297 + Sbjct: 281 FQ 282 >4NEU-A nrPDB Length = 333 Score = 186 bits (474), Expect = 7e-48, Method: Composition-based stats. Identities = 66/292 (22%), Positives = 123/292 (42%), Gaps = 35/292 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 +F + ++ G +G V ++ G ++ +K + + E ++ L H Sbjct: 25 DFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHSR 83 Query: 63 IVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +VKLL VI E K LV E++ +L + A T PL + + ++++G+ + H Sbjct: 84 VVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMST--PLSVKGRIILEIIEGMCYLHGK 141 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLA-------------RAFGVPVRTYTHEVVTLWY 168 V+H+DLKP+N+L++ + IK+AD GLA T TL+Y Sbjct: 142 GVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYY 201 Query: 169 RAPEILLGCKYY-STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD---- 223 APE L + D++S + + + + QL ++ PD Sbjct: 202 MAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDI 261 Query: 224 ---------EVVWPGVTSMPDYKPSFP----KWARQDFSKVVPPLDEDGRSL 262 ++ + P+ +P+FP K+ S++ ++ED +SL Sbjct: 262 TEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSL 313 >4C59-A nrPDB Length = 340 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 70/304 (23%), Positives = 122/304 (40%), Gaps = 59/304 (19%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HP 61 + + EG + VY+A++ +G ALK++ + E + I+E+ +K+L+ HP Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKN--RAIIQEVCFMKKLSGHP 85 Query: 62 NIVKL-----LDVIHTEN---KLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLL 112 NIV+ + ++ + L+ E L +F+ G + + +Q Sbjct: 86 NIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTC 145 Query: 113 QGLAFCHSHR--VLHRDLKPQNLLINTEGAIKLADFGLARAFGVP------------VRT 158 + + H + ++HRDLK +NLL++ +G IKL DFG A V Sbjct: 146 RAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEE 205 Query: 159 YTHEVVTLWYRAPEILLGCKYY--STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF 216 T YR PEI+ + DIW+LGCI + R+ F +++ RI Sbjct: 206 EITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL----RIV 261 Query: 217 RTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS 276 G S+P + + + SL+ ML +P +R+S Sbjct: 262 N-----------GKYSIPPHDTQYTVF----------------HSLIRAMLQVNPEERLS 294 Query: 277 AKAA 280 Sbjct: 295 IAEV 298 >6J5U-C nrPDB Length = 426 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 68/294 (23%), Positives = 119/294 (40%), Gaps = 28/294 (9%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLT---------GEVVALKKIRLDTETEGVPSTAIREI 52 +NF++ +GEG +G V+K T G VVA+K+++ E + E+ Sbjct: 84 KNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLK--PEGFQGHKEWLTEV 141 Query: 53 SLLKELNHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQL 111 + L +L+HPN+V L+ LV+EF+ L+ + + + Sbjct: 142 NYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGA 201 Query: 112 LQGLAFCHSHR--VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY--THEVVTLW 167 +GL F H + V++RD K N+L++ + KL+DFGLA+A T+ T + T Sbjct: 202 AKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHG 261 Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227 Y APE + + D++S G + E+++ R + G +V Sbjct: 262 YAAPEYV-ATGRLTAKSDVYSFGVVLLELISGRRAMDNSNG-----------GNEYSLVD 309 Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281 + D + F + + +L Q L+ D R L Sbjct: 310 WATPYLGDKRKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVL 363 >4X3F-A nrPDB Length = 337 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 69/280 (24%), Positives = 110/280 (39%), Gaps = 39/280 (13%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIREISLLKELNHP 61 ++ I G G V++A + G VA+K ++ + ++ E LNHP Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 72 Query: 62 NIVKLLDVIH-----TENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGL 115 I + D YLV E ++ + L + + + L L Q + L Sbjct: 73 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRAL 130 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV-VTLWYRAPEIL 174 H+ ++HRD+KP N+LI G +K+ DFG+A+A T T V T Y APE Sbjct: 131 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 190 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 LG S A D++SLG + E V+ + F GD + + + Sbjct: 191 LGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK----------------- 232 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 274 + + P L + R L+ L +P R Sbjct: 233 -----------EPPPPLPPDLPPNVRELIEITLVKNPAMR 261 >4OW8-A nrPDB Length = 283 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 69/280 (24%), Positives = 110/280 (39%), Gaps = 39/280 (13%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIREISLLKELNHP 61 ++ I G G V++A + G VA+K ++ + ++ E LNHP Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 62 NIVKLLDVIH-----TENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGL 115 I + D YLV E ++ + L + + + L L Q + L Sbjct: 72 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRAL 129 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV-VTLWYRAPEIL 174 H+ ++HRD+KP N+LI G +K+ DFG+A+A T T V T Y APE Sbjct: 130 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 189 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 LG S A D++SLG + E V+ + F GD + + + Sbjct: 190 LGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK----------------- 231 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 274 + + P L + R L+ L +P R Sbjct: 232 -----------EPPPPLPPDLPPNVRELIEITLVKNPAMR 260 >6B2Q-A nrPDB Length = 317 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 69/280 (24%), Positives = 110/280 (39%), Gaps = 39/280 (13%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIREISLLKELNHP 61 ++ I G G V++A + G VA+K ++ + ++ E LNHP Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 62 NIVKLLDVIH-----TENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGL 115 I + D YLV E ++ + L + + + L L Q + L Sbjct: 93 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRAL 150 Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV-VTLWYRAPEIL 174 H+ ++HRD+KP N+LI G +K+ DFG+A+A T T V T Y APE Sbjct: 151 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 210 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 LG S A D++SLG + E V+ + F GD + + + Sbjct: 211 LGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK----------------- 252 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 274 + + P L + R L+ L +P R Sbjct: 253 -----------EPPPPLPPDLPPNVRELIEITLVKNPAMR 281 >6CTH-A nrPDB Length = 309 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 58/203 (28%), Positives = 95/203 (46%), Gaps = 9/203 (4%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 NF K+GEG +G VY+ + + +A+KK+ ++ E+ ++ L H N Sbjct: 16 NFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSR--ASKQGIKEYASEVKIISRLRHKN 73 Query: 63 IVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +VKL+ H +L LV+EF+ + L + + + + + L L + H Sbjct: 74 LVKLIGWCHERGELMLVYEFMANGSLDSHI-FKGKSLLTWEVRYRIVKDLASALLYLHEE 132 Query: 122 R---VLHRDLKPQNLLINTEGAIKLADFGLARAFGVP-VRTYTHEVVTLWYRAPEILLGC 177 VLHRD+K N+++++ KL DFGLAR T T+ Y APE L Sbjct: 133 GDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSG 192 Query: 178 KYYSTAVDIWSLGCIFAEMVTRR 200 K S D++S G + E+ + R Sbjct: 193 KA-SKESDVYSFGVVALEIASGR 214 >4X7Q-B nrPDB Length = 312 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 74/303 (24%), Positives = 117/303 (38%), Gaps = 50/303 (16%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP----STAIREISLLKEL 58 ++ +G+G +G V+ VA+K I + P T E++LL ++ Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 59 N----HPNIVKLLDVIHTENKLYLVFE--FLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112 HP +++LLD T+ LV E QDL ++ G + + Q++ Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLG--EGPSRCFFGQVV 149 Query: 113 QGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAP 171 + CHS V+HRD+K +N+LI+ G KL DFG YT T Y P Sbjct: 150 AAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD--EPYTDFDGTRVYSPP 207 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT 231 E + +Y++ +WSLG + +MV F D EI + F +PD Sbjct: 208 EWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCA----- 262 Query: 232 SMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291 L+ + L P+ R S + L P+ Q + Sbjct: 263 ------------------------------LIRRCLAPKPSSRPSLEEILLDPWMQTPAE 292 Query: 292 PVP 294 VP Sbjct: 293 DVP 295 >3PLS-A nrPDB Length = 298 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 65/252 (25%), Positives = 119/252 (47%), Gaps = 22/252 (8%) Query: 8 EKIGEGTYGVVYKARNK---LTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64 IG+G +GVVY A+K + TE + V +RE L++ LNHPN++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQV-EAFLREGLLMRGLNHPNVL 85 Query: 65 KLLDVIHTENKL-YLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 L+ ++ L +++ ++ H DL +F+ + LI S+ Q+ +G+ + + Sbjct: 86 ALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLI-SFGLQVARGMEYLAEQK 144 Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILLGCK 178 +HRDL +N +++ +K+ADFGLAR V+ + H + + + A E L + Sbjct: 145 FVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYR 204 Query: 179 YYSTAVDIWSLGCIFAEMVT-RRALFPGDSEID------QLFRIFRTLGTPD---EVVWP 228 ++T D+WS G + E++T + D Q R+ + PD +V+ Sbjct: 205 -FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQ 263 Query: 229 GVTSMPDYKPSF 240 + P +P+F Sbjct: 264 CWEADPAVRPTF 275 >3ZZW-A nrPDB Length = 289 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 66/274 (24%), Positives = 120/274 (43%), Gaps = 34/274 (12%) Query: 5 QKVEKIGEGTYGVVYKAR--NKLTGEV---VALKKIRLDTETEGVPSTAIREISLLKELN 59 + +E++GE +G VYK GE VA+K ++ E + E L L Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGP-LREEFRHEAMLRARLQ 70 Query: 60 HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFM--------------DASALTGIPLPLI 104 HPN+V LL V+ + L ++F + H DL +F+ D + + + P Sbjct: 71 HPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDF 130 Query: 105 KSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG--VPVRTYTHE 162 + Q+ G+ + SH V+H+DL +N+L+ + +K++D GL R + + Sbjct: 131 VHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNS 190 Query: 163 VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEID--QLFRIFRTL 219 ++ + + APE ++ +S DIWS G + E+ + + G S D ++ R + L Sbjct: 191 LLPIRWMAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVL 249 Query: 220 GTPDE-------VVWPGVTSMPDYKPSFPKWARQ 246 PD+ ++ P +P F + Sbjct: 250 PCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSR 283 >3AOX-A nrPDB Length = 344 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 53/263 (20%), Positives = 101/263 (38%), Gaps = 23/263 (8%) Query: 2 ENFQKVEKIGEGTYGVVYKAR-----NKLTGEVVALKKIRLDTETEGVPSTAIREISLLK 56 +N + +G G +G VY+ + N + VA+K + + +E + E ++ Sbjct: 47 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EVCSEQDELDFLMEALIIS 105 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDA-----SALTGIPLPLIKSYLFQ 110 + NH NIV+ + V +++ E + DLK F+ S + + + + Sbjct: 106 KFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARD 165 Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEG---AIKLADFGLARAFGVPVRTYTHEVV--T 165 + G + + +HRD+ +N L+ G K+ DFG+AR Sbjct: 166 IACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLP 225 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDE 224 + + PE + +++ D WS G + E+ + +P S + L + Sbjct: 226 VKWMPPEAFME-GIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPP 284 Query: 225 VVWPGVTSMPDYKPSFPKWARQD 247 PG P Y+ W Q Sbjct: 285 KNCPG----PVYRIMTQCWQHQP 303 >3MDY-A nrPDB Length = 337 Score = 181 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 70/299 (23%), Positives = 122/299 (40%), Gaps = 39/299 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + Q V++IG+G YG V+ + + GE VA+K E T I + L++ H Sbjct: 37 KQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLMR---HE 91 Query: 62 NIVKLLDVIHTEN----KLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 NI+ + +LYL+ ++ L ++ + T + + + + GL Sbjct: 92 NILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKS---TTLDAKSMLKLAYSSVSGLC 148 Query: 117 FCH--------SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----THEVV 164 H + HRDLK +N+L+ G +AD GLA F V Sbjct: 149 HLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVG 208 Query: 165 TLWYRAPEIL---LGCKYYSTA--VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTL 219 T Y PE+L L ++ + D++S G I E+ RR + G E QL Sbjct: 209 TKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVA-RRCVSGGIVEEYQLPYHDLVP 267 Query: 220 GTPDEVVWPGVTSMPDYKPSFP-KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA 277 P + + +PSFP +W+ + + + L+++ ++P R++A Sbjct: 268 SDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGK-------LMTECWAHNPASRLTA 319 >3Q4U-A nrPDB Length = 301 Score = 180 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 65/307 (21%), Positives = 107/307 (34%), Gaps = 57/307 (18%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + +E +G+G YG V++ GE VA+K E T + +L+ H N Sbjct: 9 DITLLECVGKGRYGEVWRG--SWQGENVAVKIFSSRDEKSWFRETELYNTVMLR---HEN 63 Query: 63 IVKLLDVIHTENK----LYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 I+ + T L+L+ + L ++ + L + + + GLA Sbjct: 64 ILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVS---CLRIVLSIASGLAH 120 Query: 118 CH--------SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----THEVVT 165 H + HRDLK +N+L+ G +AD GLA V T Sbjct: 121 LHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGT 180 Query: 166 LWYRAPEILLGCKYYS-----TAVDIWSLGCIFAEMVTR----------RALFPGDSEID 210 Y APE+L VDIW+ G + E+ R + F Sbjct: 181 KRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDV---- 236 Query: 211 QLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYD 270 P V + +P+ P D P L + L+ + + + Sbjct: 237 -------VPNDPSFEDMRKVVCVDQQRPNIPNRWFSD-----PTLTSLAK-LMKECWYQN 283 Query: 271 PNKRISA 277 P+ R++A Sbjct: 284 PSARLTA 290 >2PMN-X nrPDB Length = 348 Score = 180 bits (457), Expect = 6e-46, Method: Composition-based stats. Identities = 59/315 (18%), Positives = 116/315 (36%), Gaps = 39/315 (12%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI---------------RLDTETEGVP 45 + +++ + + +G + + + ALKK + Sbjct: 30 INDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKY 87 Query: 46 STAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQD-------LKKFMDASALTG 98 E+ ++ ++ + + +I +++Y+++E++ D +D + Sbjct: 88 DDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCF 147 Query: 99 IPLPLIKSYLFQLLQGLAFCH-SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR 157 IP+ +IK + +L ++ H + HRD+KP N+L++ G +KL+DFG + + Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVD--K 205 Query: 158 TYTHEVVTLWYRAPEILLGCKYY-STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF 216 T + PE Y VDIWSLG M F + +LF Sbjct: 206 KIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNI 265 Query: 217 RTLGTPDEVVWPGVTSMPDYKPSFP-KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI 275 RT P + F + + L + L L +P +RI Sbjct: 266 RTKNI----------EYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERI 315 Query: 276 SAKAALAHPFFQDVT 290 +++ AL H + D Sbjct: 316 TSEDALKHEWLADTN 330 >4Y83-A nrPDB Length = 332 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 66/275 (24%), Positives = 102/275 (37%), Gaps = 32/275 (11%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69 I G +G VY A++ T + +A K I +D + + H NI +L Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD-------VEIQACFRHENIAELYGA 133 Query: 70 IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLK 129 + ++L E + + I +L+GL F HS +V+H D+K Sbjct: 134 VLWGETVHLFMEAGEGG-SVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIK 192 Query: 130 PQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL 189 P N++ + A+ L DFGL+ V T Y +PE++L C+ +ST DI+SL Sbjct: 193 PSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL-CRGHSTKADIYSL 250 Query: 190 GCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFS 249 G M T + V ++ P Y K A Sbjct: 251 GATLIHMQTGTPPW---------------------VKRYPRSAYPSYLYIIHKQAP-PLE 288 Query: 250 KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284 + R L+ L +PN R A L H Sbjct: 289 DIADDCSPGMRELIEASLERNPNHRPRAADLLKHE 323 >3G2F-A nrPDB Length = 336 Score = 177 bits (450), Expect = 4e-45, Method: Composition-based stats. Identities = 73/311 (23%), Positives = 127/311 (40%), Gaps = 44/311 (14%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 ++N + +E IG G YG VYK L VA+K + I + L++ H Sbjct: 12 LDNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFINEKNIYRVPLME---H 66 Query: 61 PNIVKLL---DVIHTENKL--YLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114 NI + + + + + ++ LV E+ + L K++ + + +G Sbjct: 67 DNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSC---RLAHSVTRG 123 Query: 115 LAFCH---------SHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--------GVPVR 157 LA+ H + HRDL +N+L+ +G ++DFGL+ G Sbjct: 124 LAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDN 183 Query: 158 TYTHEVVTLWYRAPEILLG------CKYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEID 210 EV T+ Y APE+L G C+ VD+++LG I+ E+ R LFPG+S + Sbjct: 184 AAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPE 243 Query: 211 -QLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHY 269 Q+ P + S +P FP+ +++ V + + Sbjct: 244 YQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVR-----SLKETIEDCWDQ 298 Query: 270 DPNKRISAKAA 280 D R++A+ A Sbjct: 299 DAEARLTAQCA 309 >5WNL-A nrPDB Length = 342 Score = 177 bits (449), Expect = 6e-45, Method: Composition-based stats. Identities = 59/285 (20%), Positives = 111/285 (38%), Gaps = 33/285 (11%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 F EK+G G +G VYK R+ +A+K + + E ++ Sbjct: 21 EFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRY 80 Query: 63 IVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH-- 119 I+ + + + LV E++ L+K + A +P L + + G+ F H Sbjct: 81 ILPVYGICQE--PVGLVMEYMETGSLEKLL---ASEPLPWDLRFRIVHETAVGMNFLHCM 135 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP---VRTYTHEVVTLWYRAPEILLG 176 S +LH +LKP N+L++ +K++DFGLA+ G+ + T+ Y PE + Sbjct: 136 SPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIRE 195 Query: 177 -CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 + + T D++S + ++T++ F + I + + Sbjct: 196 KSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKV----------------VKG 239 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA 280 ++P P R P L+ + H DP R + + Sbjct: 240 HRPELPPICRP-----RPRACASLIGLMQRCWHADPQVRPTFQEI 279 >4FL3-A nrPDB Length = 635 Score = 176 bits (447), Expect = 9e-45, Method: Composition-based stats. Identities = 52/224 (23%), Positives = 107/224 (47%), Gaps = 13/224 (5%) Query: 8 EKIGEGTYGVVYKARNK--LTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVK 65 +++G G +G V K + + VA+K ++ + + + E +++++L++P IV+ Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 66 LLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 ++ + E+ + LV E L K++ + + I + Q+ G+ + + Sbjct: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNR--HVKDKNIIELVHQVSMGMKYLEESNFV 491 Query: 125 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILLGCKYYS 181 HRDL +N+L+ T+ K++DFGL++A Y + W + APE + K +S Sbjct: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-FS 550 Query: 182 TAVDIWSLGCIFAEMVT-RRALFPGD--SEIDQLFRIFRTLGTP 222 + D+WS G + E + + + G SE+ + +G P Sbjct: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 >5TE0-A nrPDB Length = 347 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 73/314 (23%), Positives = 123/314 (39%), Gaps = 62/314 (19%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVKL 66 E + EG + +V+ R G ALK++ ++ E + REI ++++L+ H NIV Sbjct: 25 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHD--LQVCKREIQIMRDLSGHKNIVGY 81 Query: 67 LDVIHTEN------KLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 +D ++ ++ +F + M+ TG + + +A H Sbjct: 82 IDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLH 141 Query: 120 SHR--VLHRDLKPQNLLINTEGAIKLADFGLA-RAFGVPVRTYTHEV-------VTLWYR 169 + ++HRDLK +N+L++ G L DFG A F P + V TL YR Sbjct: 142 QCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYR 201 Query: 170 APEI--LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227 APE+ L K +T DIW+LGC+ ++ F G + Sbjct: 202 APEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF----------------GESQVAIC 245 Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 G ++PD +D L+ ML DP+KR +F Sbjct: 246 DGNFTIPD----------------NSRYSQDMHCLIRYMLEPDPDKRPDIYQV---SYFS 286 Query: 288 ----DVTKPVPHLR 297 P+P+++ Sbjct: 287 FKLLKKECPIPNVQ 300 >3SOC-A nrPDB Length = 322 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 113/295 (38%), Gaps = 35/295 (11%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 Q +E G +G V+KA+ E VA+K + + E+ L + H NI Sbjct: 26 LQLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNE---YEVYSLPGMKHENI 80 Query: 64 VKLLDVIHTEN----KLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 ++ + L+L+ F L F+ A+ ++ L I + +GLA+ Sbjct: 81 LQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETM---ARGLAYL 137 Query: 119 HS----------HRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTL 166 H + HRD+K +N+L+ +ADFGLA F G +V T Sbjct: 138 HEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTR 197 Query: 167 WYRAPEILLGCKYYST----AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP 222 Y APE+L G + +D++++G + E+ +R G + L P Sbjct: 198 RYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHP 257 Query: 223 DEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA 277 V +P + ++ + L E + + +D R+SA Sbjct: 258 SLEDMQEVVVHKKKRPVLRDYWQK--HAGMAMLCET----IEECWDHDAEARLSA 306 >3QD2-B nrPDB Length = 332 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 76/336 (22%), Positives = 127/336 (37%), Gaps = 85/336 (25%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60 + +F+ ++ +G G +GVV++A+NK+ A+K+IRL E +RE+ L +L H Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNR-ELAREKVMREVKALAKLEH 63 Query: 61 PNIVKLL---------------------------------------------DVIHTEN- 74 P IV+ D T+N Sbjct: 64 PGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNT 123 Query: 75 -----------KLYLVFEFLHQ-DLKKFM-DASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 LY+ + + +LK +M +L + Q+ + + F HS Sbjct: 124 VGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSK 183 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR------------TYTHEVVTLWYR 169 ++HRDLKP N+ + +K+ DFGL A T+T +V T Y Sbjct: 184 GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYM 243 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 +PE + G YS VDI+SLG I E++ S Q+ R+ R + + +P Sbjct: 244 SPEQIHG-NNYSHKVDIFSLGLILFELLY--------SFSTQMERV-RIITDVRNLKFPL 293 Query: 230 VTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQ 265 + + K QD P + ++ Sbjct: 294 LFTQ---KYPQEHMMVQDMLSPSPTERPEATDIIEN 326 >4IDT-A nrPDB Length = 356 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 70/310 (22%), Positives = 117/310 (37%), Gaps = 59/310 (19%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 ++G G++G V++ +K TG A+KK+RL+ E+ L P IV L Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE-------ELMACAGLTSPRIVPLYG 133 Query: 69 VIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 + + + E L L + + +P YL Q L+GL + HS R+LH D Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGC--LPEDRALYYLGQALEGLEYLHSRRILHGD 191 Query: 128 LKPQNLLINTEG-AIKLADFGLA-----RAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 +K N+L++++G L DFG A G + T + T + APE++LG + Sbjct: 192 VKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG-RSCD 250 Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 VD+WS C+ M+ + FR P Sbjct: 251 AKVDVWSSCCMMLHMLNGCHP---------WTQFFRGPLCLKIASEPP------------ 289 Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA-------------LAHPF--- 285 ++ P + + L +P R+SA L P+ Sbjct: 290 -----PVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGE 344 Query: 286 FQDVTKPVPH 295 +++ P P+ Sbjct: 345 YKEPRHPPPN 354 >3UIM-A nrPDB Length = 326 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 55/209 (26%), Positives = 99/209 (47%), Gaps = 10/209 (4%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +NF +G G +G VYK R G +VA+K+++ + T+G E+ ++ H Sbjct: 30 DNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLK-EERTQGGELQFQTEVEMISMAVHR 87 Query: 62 NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPL--IKSYLFQLLQGLAFC 118 N+++L T + LV+ ++ + + + + PL + +GLA+ Sbjct: 88 NLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYL 147 Query: 119 HSH---RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV-VTLWYRAPEIL 174 H H +++HRD+K N+L++ E + DFGLA+ T V T+ + APE L Sbjct: 148 HDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYL 207 Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALF 203 K S D++ G + E++T + F Sbjct: 208 STGKS-SEKTDVFGYGVMLLELITGQRAF 235 >5LPZ-A nrPDB Length = 332 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 55/207 (26%), Positives = 94/207 (45%), Gaps = 12/207 (5%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 F IG G +G VYKA K G VA+KK+ + + E+ + ++ H N+ Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIH--VSGQGDREFMAEMETIGKIKHRNL 75 Query: 64 VKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTG--IPLPLIKSYLFQLLQGLAFCH- 119 V LL ++ LV+EF+ + L+ + G + + +GLAF H Sbjct: 76 VPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHH 135 Query: 120 --SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG--VPVRTYTHEVVTLWYRAPEILL 175 S ++HRD+K N+L++ +++DFG+AR + + T Y PE Sbjct: 136 NCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRAL 202 + ST D++S G + E++T + Sbjct: 196 SFRC-STKGDVYSYGVVLLELLTGKRP 221 >5WNO-A nrPDB Length = 330 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 57/270 (21%), Positives = 110/270 (40%), Gaps = 19/270 (7%) Query: 5 QKVEKIGEGTYGVVYKA-----RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59 + +K+G G +G V+ R K VA+K + D + + E + + L Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTD---QSQTDEMLEEATNMFRLR 81 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 H N++K++ ++ L +V + +L+ F+ + Y +Q+ G+ + Sbjct: 82 HDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHK-ENLGAREQVLYCYQIASGMQYL 140 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--TLWYRAPEILLG 176 RV+HRDL +N+L+ +++ DFGL++ + T + + + A EI Sbjct: 141 EKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSK 200 Query: 177 CKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 Y+ A D+W+ G E++T ++ + G S I L + + P S Sbjct: 201 H-CYTHASDVWAFGVTCWEIITFGQSPYQGMSTDS----IHNFLKDGNRLSQPPNCSQDL 255 Query: 236 YKPSFPKWARQDFSK-VVPPLDEDGRSLLS 264 Y+ W S+ L E + Sbjct: 256 YQELLRCWMADPKSRPGFEILYERFKEFCK 285 >1PY5-A nrPDB Length = 326 Score = 174 bits (441), Expect = 5e-44, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 122/297 (41%), Gaps = 43/297 (14%) Query: 6 KVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK--ELNHPNI 63 E IG+G +G V++ + + GE VA+K + + RE + + L H NI Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIF-----SSREERSWFREAEIYQTVMLRHENI 85 Query: 64 VKLLDVIHTEN----KLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 + + + +N +L+LV ++ H L +++ + + + GLA Sbjct: 86 LGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT---VTVEGMIKLALSTASGLAHL 142 Query: 119 H--------SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----THEVVTL 166 H + HRDLK +N+L+ G +AD GLA T H V T Sbjct: 143 HMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTK 202 Query: 167 WYRAPEIL---LGCKYYS--TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGT 221 Y APE+L + K++ DI+++G +F E+ R ++ G E QL Sbjct: 203 RYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSD 261 Query: 222 PDEVVWPGVTSMPDYKPSFP-KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA 277 P V +P+ P +W + +V+ + + + + + R++A Sbjct: 262 PSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKI-------MRECWYANGAARLTA 311 >5LPV-A nrPDB Length = 296 Score = 173 bits (440), Expect = 6e-44, Method: Composition-based stats. Identities = 55/207 (26%), Positives = 94/207 (45%), Gaps = 12/207 (5%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 F IG G +G VYKA K G VA+KK+ + + E+ + ++ H N+ Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIH--VSGQGDREFMAEMETIGKIKHRNL 75 Query: 64 VKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTG--IPLPLIKSYLFQLLQGLAFCH- 119 V LL ++ LV+EF+ + L+ + G + + +GLAF H Sbjct: 76 VPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHH 135 Query: 120 --SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG--VPVRTYTHEVVTLWYRAPEILL 175 S ++HRD+K N+L++ +++DFG+AR + + T Y PE Sbjct: 136 NCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRAL 202 + ST D++S G + E++T + Sbjct: 196 SFRC-STKGDVYSYGVVLLELLTGKRP 221 >5C26-A nrPDB Length = 299 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 52/224 (23%), Positives = 107/224 (47%), Gaps = 13/224 (5%) Query: 8 EKIGEGTYGVVYKARNK--LTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVK 65 +++G G +G V K + + VA+K ++ + + + E +++++L++P IV+ Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 66 LLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 ++ + E+ + LV E L K++ + + I + Q+ G+ + + Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQNR--HVKDKNIIELVHQVSMGMKYLEESNFV 149 Query: 125 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILLGCKYYS 181 HRDL +N+L+ T+ K++DFGL++A Y + W + APE + K +S Sbjct: 150 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-FS 208 Query: 182 TAVDIWSLGCIFAEMVT-RRALFPGD--SEIDQLFRIFRTLGTP 222 + D+WS G + E + + + G SE+ + +G P Sbjct: 209 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 252 >4JLC-A nrPDB Length = 657 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 65/242 (26%), Positives = 100/242 (41%), Gaps = 27/242 (11%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 +G+G V++ R+K TG++ A+K + V +RE +LK+LNH NIVKL Sbjct: 15 ILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFA 73 Query: 69 VIHTEN--KLYLVFEFLH-QDLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 + L+ EF L ++ S G+P L ++ G+ + ++ Sbjct: 74 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 133 Query: 125 HRDLKPQNLL--INTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG---- 176 HRD+KP N++ I +G KL DFG AR + T Y P++ Sbjct: 134 HRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLR 192 Query: 177 ---CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233 K Y VD+WS+G F T F R F EV++ +T Sbjct: 193 KDHQKKYGATVDLWSVGVTFYHAATGSLPF----------RPFEGPRRNKEVMYKIITGK 242 Query: 234 PD 235 P Sbjct: 243 PS 244 >4EUU-A nrPDB Length = 319 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 64/242 (26%), Positives = 100/242 (41%), Gaps = 27/242 (11%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 +G+G V++ R+K TG++ A+K + V +RE +LK+LNH NIVKL Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFA 74 Query: 69 VIHTEN--KLYLVFEFLH-QDLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 + L+ EF L ++ S G+P L ++ G+ + ++ Sbjct: 75 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 134 Query: 125 HRDLKPQNLL--INTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG---- 176 HR++KP N++ I +G KL DFG AR + T Y P++ Sbjct: 135 HRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLR 193 Query: 177 ---CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233 K Y VD+WS+G F T F R F EV++ +T Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHAATGSLPF----------RPFEGPRRNKEVMYKIITGK 243 Query: 234 PD 235 P Sbjct: 244 PS 245 >4F0G-A nrPDB Length = 287 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 66/274 (24%), Positives = 118/274 (43%), Gaps = 24/274 (8%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL-----DTETEGVPSTAIREISLLK 56 + ++IG+G +G+V+K R VVA+K + L +TE RE+ ++ Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMS 78 Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 LNHPNIVKL ++H + +V EF+ DL + I + + + G+ Sbjct: 79 NLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRL-LDKAHPIKWSVKLRLMLDIALGI 135 Query: 116 AFCHSHR--VLHRDLKPQNLL---INTEGAI--KLADFGLARAFGVPVRTYTHEVVTLWY 168 + + ++HRDL+ N+ ++ + K+ADFGL++ V + + + + Sbjct: 136 EYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ---SVHSVSGLLGNFQW 192 Query: 169 RAPEIL-LGCKYYSTAVDIWSLGCIFAEMVTRRALF----PGDSEIDQLFRIFRTLGTPD 223 APE + + Y+ D +S I ++T F G + + R T Sbjct: 193 MAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIP 252 Query: 224 EVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDE 257 E P + ++ + S R FS +V L E Sbjct: 253 EDCPPRLRNVIELCWSGDPKKRPHFSYIVKELSE 286 >4EUT-A nrPDB Length = 396 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 64/242 (26%), Positives = 100/242 (41%), Gaps = 27/242 (11%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 +G+G V++ R+K TG++ A+K + V +RE +LK+LNH NIVKL Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFA 74 Query: 69 VIHTEN--KLYLVFEFLH-QDLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 + L+ EF L ++ S G+P L ++ G+ + ++ Sbjct: 75 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 134 Query: 125 HRDLKPQNLL--INTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG---- 176 HR++KP N++ I +G KL DFG AR + T Y P++ Sbjct: 135 HRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLR 193 Query: 177 ---CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233 K Y VD+WS+G F T F R F EV++ +T Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHAATGSLPF----------RPFEGPRRNKEVMYKIITGK 243 Query: 234 PD 235 P Sbjct: 244 PS 245 >4F9B-A nrPDB Length = 361 Score = 170 bits (432), Expect = 5e-43, Method: Composition-based stats. Identities = 76/346 (21%), Positives = 128/346 (36%), Gaps = 67/346 (19%) Query: 4 FQKVEKIGEGTYGVVYKARNKLT---GEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59 F+ +KIGEGT+ VY A +L E +ALK + P E+ L Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHL----IPTSHPIRIAAELQCLTVAGG 78 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 N++ + + + + +L + F+D L + ++ Y+ L + L H Sbjct: 79 QDNVMGVKYCFRKNDHVVIAMPYLEH--ESFLDI--LNSLSFQEVREYMLNLFKALKRIH 134 Query: 120 SHRVLHRDLKPQNLLINTEGAIK-LADFGLARAFGVPV---------------------- 156 ++HRD+KP N L N L DFGLA+ Sbjct: 135 QFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCS 194 Query: 157 ------RTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFP-GDSEI 209 + T +RAPE+L C +TA+D+WS G IF +++ R F ++ Sbjct: 195 ICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDL 254 Query: 210 DQLFRIFRTLGTPDEVV--------WPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRS 261 L +I G+ + + +P + P L D + Sbjct: 255 TALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQG 314 Query: 262 LLSQMLHY-----------------DPNKRISAKAALAHPFFQDVT 290 + + + +P RI+A+ AL HPFF+D++ Sbjct: 315 HATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMS 360 >4G3E-A nrPDB Length = 352 Score = 170 bits (431), Expect = 8e-43, Method: Composition-based stats. Identities = 57/201 (28%), Positives = 95/201 (47%), Gaps = 17/201 (8%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 ++G G++G V++ ++K TG A+KK+RL+ + E+ L+ P IV L Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR-------VEELVACAGLSSPRIVPLYG 133 Query: 69 VIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 + + + E L L + + +P YL Q L+GL + H+ R+LH D Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLIKQMGC--LPEDRALYYLGQALEGLEYLHTRRILHGD 191 Query: 128 LKPQNLLINTEG-AIKLADFGLA-----RAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181 +K N+L++++G L DFG A G + T + T + APE+++G K Sbjct: 192 VKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-KPCD 250 Query: 182 TAVDIWSLGCIFAEMVTRRAL 202 VDIWS C+ M+ Sbjct: 251 AKVDIWSSCCMMLHMLNGCHP 271 >3MY0-A nrPDB Length = 305 Score = 170 bits (430), Expect = 8e-43, Method: Composition-based stats. Identities = 68/294 (23%), Positives = 105/294 (35%), Gaps = 37/294 (12%) Query: 6 KVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVK 65 VE +G+G YG V++ GE VA+K E T I LL+ H NI+ Sbjct: 12 LVECVGKGRYGEVWRG--LWHGESVAVKIFSSRDEQSWFRETEIYNTVLLR---HDNILG 66 Query: 66 LLDVIHTE----NKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH- 119 + T +L+L+ + H L F+ + L GLA H Sbjct: 67 FIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQT---LEPHLALRLAVSAACGLAHLHV 123 Query: 120 -------SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----THEVVTLWY 168 + HRD K +N+L+ + +AD GLA V T Y Sbjct: 124 EIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRY 183 Query: 169 RAPEILLGCKYYS-----TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD 223 APE+L DIW+ G + E+ RR + G E + P Sbjct: 184 MAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA-RRTIVNGIVEDYRPPFYDVVPNDPS 242 Query: 224 EVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA 277 V + P+ P D P L + ++ + + +P+ R++A Sbjct: 243 FEDMKKVVCVDQQTPTIPNRLAAD-----PVLSGLAQ-MMRECWYPNPSARLTA 290 >2QKW-B nrPDB Length = 321 Score = 170 bits (430), Expect = 9e-43, Method: Composition-based stats. Identities = 62/285 (21%), Positives = 109/285 (38%), Gaps = 21/285 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 NF IG G +G VYK + G VALK R E+ EI L HP Sbjct: 39 NNFDHKFLIGHGVFGKVYKGVLR-DGAKVALK--RRTPESSQGIEEFETEIETLSFCRHP 95 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALT--GIPLPLIKSYLFQLLQGLAFC 118 ++V L+ N++ L+++++ +LK+ + S L + +GL + Sbjct: 96 HLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYL 155 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV--VTLWYRAPEILLG 176 H+ ++HRD+K N+L++ K+ DFG+++ +T+ V TL Y PE + Sbjct: 156 HTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIK 215 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 + + D++S G + E++ R+ I ++L + + Sbjct: 216 GRL-TEKSDVYSFGVVLFEVLCARS------------AIVQSLPREMVNLAEWAVESHNN 262 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281 K+ P + L R S L Sbjct: 263 GQLEQIVDPNLADKIRPESLRKFGDTAVKCLALSSEDRPSMGDVL 307 >3LMG-A nrPDB Length = 344 Score = 168 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 54/276 (19%), Positives = 112/276 (40%), Gaps = 18/276 (6%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLL---KELN 59 +K++ +G G +G V+K GE + + E + + + L+ Sbjct: 32 ELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLD 91 Query: 60 HPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 H +IV+LL + + L LV ++L L + + L+ ++ Q+ +G+ + Sbjct: 92 HAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRGA-LGPQLLLNWGVQIAKGMYYL 149 Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT--YTHEVVTLWYRAPEILLG 176 H ++HR+L +N+L+ + +++ADFG+A + Y+ + + A E + Sbjct: 150 EEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIH- 208 Query: 177 CKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235 Y+ D+WS G E++T + G +L + L + + P + ++ Sbjct: 209 FGKYTHQSDVWSYGVTVWELMTFGAEPYAGL----RLAEVPDLLEKGERLAQPQICTIDV 264 Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDP 271 Y W + + P E + DP Sbjct: 265 YMVMVKCWMIDE--NIRPTFKELANEFTR--MARDP 296 >6O8B-A nrPDB Length = 665 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 64/242 (26%), Positives = 100/242 (41%), Gaps = 27/242 (11%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 +G+G V++ R+K TG++ A+K + V +RE +LK+LNH NIVKL Sbjct: 22 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFA 80 Query: 69 VIHTEN--KLYLVFEFLH-QDLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 + L+ EF L ++ S G+P L ++ G+ + ++ Sbjct: 81 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 140 Query: 125 HRDLKPQNLL--INTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG---- 176 HR++KP N++ I +G KL DFG AR + T Y P++ Sbjct: 141 HRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVELYGTEEYLHPDMYERAVLR 199 Query: 177 ---CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233 K Y VD+WS+G F T F R F EV++ +T Sbjct: 200 KDHQKKYGATVDLWSIGVTFYHAATGSLPF----------RPFEGPRRNKEVMYKIITGK 249 Query: 234 PD 235 P Sbjct: 250 PS 251 >5IKW-A nrPDB Length = 310 Score = 168 bits (425), Expect = 3e-42, Method: Composition-based stats. Identities = 72/295 (24%), Positives = 117/295 (39%), Gaps = 54/295 (18%) Query: 5 QKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNI 63 E + EG + V+ R G ALK++ ++ + + REI+++KEL+ H NI Sbjct: 17 TLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPD--LNVCKREITIMKELSGHKNI 73 Query: 64 VKLLDV---IHTEN--KLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 V LD ++N ++ ++ E+ + M+ TG P + + +A Sbjct: 74 VGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVAR 133 Query: 118 CHSHR--VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--------TLW 167 H + ++HRDLK +N+L+N G L DFG A + + VV TL Sbjct: 134 LHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLS 193 Query: 168 YRAPEILL--GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEV 225 YRAPE++ G K +T DIW+LGC+ ++ F G Sbjct: 194 YRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF----------------GESQVA 237 Query: 226 VWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA 280 + G ++PD + L+ ML DP R Sbjct: 238 ICDGNFTIPD----------------NSRYSRNIHCLIRFMLEPDPEHRPDIFQV 276 >6NT9-A nrPDB Length = 742 Score = 168 bits (425), Expect = 3e-42, Method: Composition-based stats. Identities = 64/242 (26%), Positives = 100/242 (41%), Gaps = 27/242 (11%) Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68 +G+G V++ R+K TG++ A+K + V +RE +LK+LNH NIVKL Sbjct: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFA 72 Query: 69 VIHTEN--KLYLVFEFLH-QDLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 + L+ EF L ++ S G+P L ++ G+ + ++ Sbjct: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIV 132 Query: 125 HRDLKPQNLL--INTEGA--IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG---- 176 HR++KP N++ I +G KL DFG AR + T Y P++ Sbjct: 133 HRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLR 191 Query: 177 ---CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233 K Y VD+WS+G F T F R F EV++ +T Sbjct: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPF----------RPFEGPRRNKEVMYKIITGK 241 Query: 234 PD 235 P Sbjct: 242 PS 243 >4LQP-A nrPDB Length = 508 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 72/338 (21%), Positives = 128/338 (37%), Gaps = 62/338 (18%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNH 60 E+F V+ IG+G +G V + K TG++ A+K + + + + + E +L + Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 P +V L LYL+ EFL DL + L + + Y+ + + + H Sbjct: 162 PWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQL--FTEDVTRFYMAECILAIETIH 219 Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV--------------VT 165 +HR +KP N+LI+ G IKL+DFGL+ F + ++ T Sbjct: 220 KLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGT 279 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDE- 224 Y A K + VD SL M R+ + + + T+GTPD Sbjct: 280 --YNANTTDTANKRQTMVVDSISL-----TMSNRQQIQTWRKSRRLMA--YSTVGTPDYI 330 Query: 225 ---------------------VVWPGVTSMPDYKPSFPKWARQDFSKVVPPL-------- 255 +++ + P + P+ + L Sbjct: 331 APEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHI 390 Query: 256 DEDGRSLLSQMLHYDPNKRI----SAKAALAHPFFQDV 289 + L+ ++L + ++R+ A +HPFF+ V Sbjct: 391 SYEAEDLIRRLLTH-ADQRLGRHGGADEIKSHPFFRGV 427 >2BUJ-A nrPDB Length = 317 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 113/307 (36%), Gaps = 52/307 (16%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +++ ++K+GEG + V G ALK+I + A RE + + NHP Sbjct: 29 KHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRIL--CHEQQDREEAQREADMHRLFNHP 86 Query: 62 NIVKLLDVIHTEN----KLYLVFEFL-HQDLKKFMDASALTG--IPLPLIKSYLFQLLQG 114 NI++L+ E + +L+ F L ++ G + I L + +G Sbjct: 87 NILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRG 146 Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR---------TYTHEVVT 165 L H+ HRDLKP N+L+ EG L D G + V + + T Sbjct: 147 LEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCT 206 Query: 166 LWYRAPEILLGCKY--YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD 223 + YRAPE+ + D+WSLGC+ M+ + + G Sbjct: 207 ISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYD----------MVFQKGDSV 256 Query: 224 EVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR------ISA 277 + S+P P LL+ M+ DP++R +S Sbjct: 257 ALAVQNQLSIPQ----------------SPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQ 300 Query: 278 KAALAHP 284 AL P Sbjct: 301 LEALQPP 307 >2Y4I-B nrPDB Length = 319 Score = 165 bits (418), Expect = 2e-41, Method: Composition-based stats. Identities = 59/299 (19%), Positives = 123/299 (41%), Gaps = 37/299 (12%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E + E IG+G +G VY R VA++ I ++ + E RE+ ++ H Sbjct: 33 EQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE 89 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 N+V + + L ++ + A + + + ++++G+ + H+ Sbjct: 90 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK 149 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGL---ARAFGVPVRTYTHEVVTLW--YRAPEILLG 176 +LH+DLK +N+ + G + + DFGL + R + W + APEI+ Sbjct: 150 GILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQ 208 Query: 177 CK--------YYSTAVDIWSLGCIFAEMVTRRALF---PGDSEIDQLFRIFRTLGTPDEV 225 +S D+++LG I+ E+ R F P ++ I Q+ + Sbjct: 209 LSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMK-PNLSQIG 267 Query: 226 VWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284 + ++ + + +F + R F+K++ +L ++ + +R+S HP Sbjct: 268 MGKEISDILLFCWAFEQEERPTFTKLM--------DMLEKLPKRN--RRLS------HP 310 >5XD6-A nrPDB Length = 305 Score = 164 bits (415), Expect = 5e-41, Method: Composition-based stats. Identities = 52/214 (24%), Positives = 91/214 (42%), Gaps = 18/214 (8%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 +N+ IGEG+YG V+ K +G+ A+KK+ + + + ++S++ L Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD---QEFLAQVSMVSRLRQE 77 Query: 62 NIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTG-------IPLPLIKSYLFQLLQ 113 N+V LL L +E+ + L + + + Sbjct: 78 NVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAAR 137 Query: 114 GLAFCHSH---RVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEV-VTLWY 168 GL + H V+HRD+K N+L+ + K+ADF L+ + R ++ V T Y Sbjct: 138 GLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGY 197 Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRAL 202 APE + ST D++S G + E++T R Sbjct: 198 HAPEYAM-TGTLSTKSDVYSFGVVLLELLTGRKP 230 >2H34-A nrPDB Length = 309 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 61/277 (22%), Positives = 115/277 (41%), Gaps = 18/277 (6%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGV-PSTAIREISLLKELNHPN 62 ++ +G G G VY+A + + +VALK + ++ V + RE L P+ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 +V + D + +LY+ ++ DL + + P + + Q+ L H+ Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGP--LAPPRAVAIVRQIGSALDAAHAA 153 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY-THEVVTLWYRAPEILLGCKYY 180 HRD+KP+N+L++ + L DFG+A A T + V TL+Y APE + Sbjct: 154 GATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSES-HA 212 Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP-----------DEVVWPG 229 + DI++L C+ E +T + GD I + + P D V+ G Sbjct: 213 TYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVIARG 272 Query: 230 VTSMPDYKP-SFPKWARQDFSKVVPPLDEDGRSLLSQ 265 + P+ + + + + + + +L + Sbjct: 273 MAKNPEDRYVTCGDLSAAAHAALATADQDRATDILRR 309 >2QLU-A nrPDB Length = 314 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 115/297 (38%), Gaps = 38/297 (12%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 Q +E G +G V+KA+ + VA+K L + REI + H N+ Sbjct: 17 LQLLEIKARGRFGCVWKAQLM--NDFVAVKIFPLQDKQSWQSE---REIFSTPGMKHENL 71 Query: 64 VKLLDVIHTEN----KLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 ++ + + +L+L+ F L ++ + +T L + + +GL++ Sbjct: 72 LQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMS---RGLSYL 128 Query: 119 HS-----------HRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVT 165 H + HRD K +N+L+ ++ LADFGLA F G P +V T Sbjct: 129 HEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGT 188 Query: 166 LWYRAPEILLGCKYYST----AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGT 221 Y APE+L G + +D++++G + E+V+R G + L Sbjct: 189 RRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQH 248 Query: 222 PDEVVWPGVTSMPDYKPSFPK-WARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA 277 P V +P+ W + + + + +D R+SA Sbjct: 249 PSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVT-------IEECWDHDAEARLSA 298 >5AR8-A nrPDB Length = 326 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 63/287 (21%), Positives = 110/287 (38%), Gaps = 32/287 (11%) Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKELNHPNIVK 65 + + G G V AR+ VA+K + + T + +RE +L + I+ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 66 LLDVIHTENKLYLVFEFL-HQDLKKFMDASALT-GIPLPLIKSYLFQLLQGLAFCHSH-- 121 +L + + L +V E++ + L + + + PL L ++ G+ + H+ Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP 156 Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLAR-----AFGVPVRTYTHEVVTLWYRAPEILL- 175 +LH DLK QN+L++ E +K+ADFGL++ E T+ Y PE Sbjct: 157 PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEP 216 Query: 176 -GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234 S DI+S I E+++R+ F + Q+ P V + Sbjct: 217 GQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRP-------VINEE 269 Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281 P AR SL+ +P++R S L Sbjct: 270 SLPYDIPHRARM-------------ISLIESGWAQNPDERPSFLKCL 303 >5VDK-A nrPDB Length = 297 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 72/306 (23%), Positives = 118/306 (38%), Gaps = 62/306 (20%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NH 60 + F +VEKIG G +G VYK +L G V A+K+ ++A+ E+ L +H Sbjct: 15 KEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHH 74 Query: 61 PNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTG--IPLPLIKSYLFQLLQGLAF 117 P++V+ ++ + + E+ + L+ + + +G P +K L Q+ GL + Sbjct: 75 PHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNY 134 Query: 118 CHSHRVLHRDLKPQNLLI------NTEGAI-----------------KLADFGLARAFGV 154 H+ ++H D+KP N+ I + G I K+ D G A + Sbjct: 135 IHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINK 194 Query: 155 PVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR 214 P E + A EIL + DI++LG A Sbjct: 195 P----KVEEGDSRFLANEILQEDYRHLPKADIFALGLTIA-------------------- 230 Query: 215 IFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 274 V G S+P ++ + +F V L E SLL M+ D +R Sbjct: 231 -----------VAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQR 279 Query: 275 ISAKAA 280 SA A Sbjct: 280 PSAAAL 285 >5E8V-A nrPDB Length = 316 Score = 157 bits (397), Expect = 6e-39, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 111/308 (36%), Gaps = 48/308 (15%) Query: 10 IGEGTYGVVYKARNKLTG----EVVALKKIRLDTETEGV-PSTAIREISLLKELNHPNIV 64 +G+G + VYKA+ K E VA+K + +I L H NI+ Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDI----NLKHENIL 72 Query: 65 KLLDVIHTENKL----YLVFEF-LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 + L + +L +L+ F +L++++ I ++ L +G+A H Sbjct: 73 QFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHV---ISWEDLRKLGSSLARGIAHLH 129 Query: 120 S---------HRVLHRDLKPQNLLINTEGAIKLADFGLARAFG----VPVRTYTHEVVTL 166 S ++HRDLK N+L+ + L DFGL+ V + +V T Sbjct: 130 SDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 189 Query: 167 WYRAPEILLGCKYYS-----TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGT 221 Y APE+L D++S+ + EM +R + + Sbjct: 190 RYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRC-------NAVGEVKDYEPPFG 242 Query: 222 PDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA- 280 P V SM D + + + L++ +DP R++A+ Sbjct: 243 SKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVA 302 Query: 281 -----LAH 283 L H Sbjct: 303 ERFSELEH 310 >6BFN-A nrPDB Length = 342 Score = 156 bits (396), Expect = 9e-39, Method: Composition-based stats. Identities = 58/214 (27%), Positives = 91/214 (42%), Gaps = 19/214 (8%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEG--VPSTAIREISLLKELNH 60 NF + KIGEG +G VY+A + T V A+K+++ + + E V + + E+ L H Sbjct: 23 NFSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRH 80 Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMD--ASALTGIPLPLIKSYLFQLLQGLAF 117 PNIV LV+ FL + L+ + A + P L + + F Sbjct: 81 PNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQF 140 Query: 118 CH--SHRVLHRDLKPQNLLINTEGAIKLADFGLAR---------AFGVPVRTYTHEVVTL 166 H S ++H D+K N+L++ KL DFGLAR + V TL Sbjct: 141 LHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTL 200 Query: 167 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRR 200 Y PE + + D +S G + E + + Sbjct: 201 AYL-PEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >5VC6-A nrPDB Length = 289 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 107/304 (35%), Gaps = 58/304 (19%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NHP 61 F ++EKIG G +G V+K +L G + A+K+ + A+RE+ L H Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 62 NIVKLLDVIHTENKLYLVFEFLH-QDLKKFM--DASALTGIPLPLIKSYLFQLLQGLAFC 118 ++V+ ++ + + E+ + L + + ++ +K L Q+ +GL + Sbjct: 72 HVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYI 131 Query: 119 HSHRVLHRDLKPQNLLINTEGAI-------------------KLADFGLARAFGVPVRTY 159 HS ++H D+KP N+ I+ K+ D G P Sbjct: 132 HSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSP---- 187 Query: 160 THEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTL 219 E + A E+L + DI++L P + + R R Sbjct: 188 QVEEGDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLPRNGDQWHEIRQGRLP 246 Query: 220 GTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKA 279 P L ++ LL M+H DP +R SA A Sbjct: 247 RIPQ------------------------------VLSQEFTELLKVMIHPDPERRPSAMA 276 Query: 280 ALAH 283 + H Sbjct: 277 LVKH 280 >4M66-A nrPDB Length = 325 Score = 156 bits (394), Expect = 1e-38, Method: Composition-based stats. Identities = 72/294 (24%), Positives = 118/294 (40%), Gaps = 44/294 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 E +K+E +G+G +GVV++A ++ VA+K + + E+ + L + Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKIS--------WEVKAMVNLRNE 71 Query: 62 NIVKLLDVIHTENKLY-----LVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 N++ LL V + LV F+ L + A P PL+ L +++ G+ Sbjct: 72 NVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPR--PWPLLCRLLQEVVLGM 129 Query: 116 AFCHS--HRVLHRDLKPQNLLINTEGAIKLADFGLAR------AFGVPVRTYTHEVVTLW 167 + HS +LHRDLKP N+L++ E KLADFGL+ + TL Sbjct: 130 CYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLA 189 Query: 168 YRAPEILLGCK-YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVV 226 Y PE+L S A D++S G + ++ R +D+ I T+ D Sbjct: 190 YLDPELLFKVNLKASKASDVYSFGILVWAVLAGRE----AELVDKTSLIRETVC--DRQS 243 Query: 227 WPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA 280 P +T +P P P E + L+ R S + Sbjct: 244 RPPLTELPPGSPETPGL-------------EKLKELMIHCWGSQSENRPSFQDC 284 >6DC0-A nrPDB Length = 292 Score = 150 bits (380), Expect = 6e-37, Method: Composition-based stats. Identities = 55/275 (20%), Positives = 98/275 (35%), Gaps = 41/275 (14%) Query: 18 VYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLY 77 V +A TG + K + + + +H NI +++VI E K Y Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ-------LPSHSNITGIVEVILGETKAY 74 Query: 78 LVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT 137 + FE D+ ++ + + Q++ +A CH ++ DLK + + +T Sbjct: 75 VFFEKDFGDMHSYVRSRKR--LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFST 132 Query: 138 EG--AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS-TAVDIWSLGCIFA 194 E ++L + + Y +PEIL YS A D+WSLG + Sbjct: 133 EERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 192 Query: 195 EMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPP 254 ++ R F +I R E Sbjct: 193 TLLVGRYPFHDSDPSALFSKIRRGQFCIPE-----------------------------H 223 Query: 255 LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 + R L+ +L +P++R++A L HP+F+ V Sbjct: 224 ISPKARCLIRSLLRREPSERLTAPEILLHPWFESV 258 >5CEK-A nrPDB Length = 263 Score = 150 bits (380), Expect = 6e-37, Method: Composition-based stats. Identities = 55/275 (20%), Positives = 98/275 (35%), Gaps = 41/275 (14%) Query: 18 VYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLY 77 V +A TG + K + + + +H NI +++VI E K Y Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ-------LPSHSNITGIVEVILGETKAY 77 Query: 78 LVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT 137 + FE D+ ++ + + Q++ +A CH ++ DLK + + +T Sbjct: 78 VFFEKDFGDMHSYVRSRKR--LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFST 135 Query: 138 EG--AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS-TAVDIWSLGCIFA 194 E ++L + + Y +PEIL YS A D+WSLG + Sbjct: 136 EERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 195 Query: 195 EMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPP 254 ++ R F +I R E Sbjct: 196 TLLVGRYPFHDSDPSALFSKIRRGQFCIPE-----------------------------H 226 Query: 255 LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289 + R L+ +L +P++R++A L HP+F+ V Sbjct: 227 ISPKARCLIRSLLRREPSERLTAPEILLHPWFESV 261 >4L00-A nrPDB Length = 304 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 61/311 (19%), Positives = 115/311 (36%), Gaps = 57/311 (18%) Query: 2 ENFQKVEKIGEGTYGVVYKAR------NKLTGEVVALKKIRL--DTETEGVPSTAIREIS 53 ++ + E +G GT +Y ++ T E +K I D + S Sbjct: 25 KDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAAS 84 Query: 54 LLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQ 113 ++++++H +IV L V + + +V EF+ + P QL Sbjct: 85 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLAS 144 Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGA-------IKLADFGLARAFGVPVRTYTHEVVTL 166 L++ ++H ++ +NLL+ EG IKL+D G + V + + + Sbjct: 145 ALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPG----IPITVLSRQECIERI 200 Query: 167 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVV 226 + APE + K S A D WS G E+ + D + + R + + P Sbjct: 201 PWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRP---- 256 Query: 227 WPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286 V P ++ L+++ ++YDPN+R PFF Sbjct: 257 -------------------------VTPSCKELADLMTRCMNYDPNQR---------PFF 282 Query: 287 QDVTKPVPHLR 297 + + + + L Sbjct: 283 RAIMRDINKLE 293 >3SV0-A nrPDB Length = 483 Score = 148 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 112/288 (38%), Gaps = 28/288 (9%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH- 60 F+ KIG G++G +Y N T E VA+K + T+ + E + + L Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHP----QLLYESKIYRILQGG 62 Query: 61 ---PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 PN V+ V + LV + L L+ + + + L + Q++ + F Sbjct: 63 TGIPN-VRWFGV--EGDYNVLVMDLLGPSLEDLFNFCSRK-LSLKTVLMLADQMINRVEF 118 Query: 118 CHSHRVLHRDLKPQNLLIN---TEGAIKLADFGLARAF-------GVPVRTYTHEVVTLW 167 HS LHRD+KP N L+ + + DFGLA+ + +P R + T Sbjct: 119 VHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTAR 178 Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPG---DSEIDQLFRI-FRTLGTPD 223 Y + LG + S D+ SLG + + + G ++ + +I + + T Sbjct: 179 YASVNTHLGIEQ-SRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVATSI 237 Query: 224 EVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSL-LSQMLHYD 270 E + G + + + R D L R L + + +D Sbjct: 238 EALCRGYPTEFASYFHYCRSLRFDDKPDYSYLKRLFRDLFIREGFQFD 285 >2CHL-A nrPDB Length = 351 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 65/252 (25%), Positives = 103/252 (40%), Gaps = 25/252 (9%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH-P 61 NF+ +KIG G +G + +N T E VA+K L+ P + E K+L Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPMKSRAPQLHL-EYRFYKQLGSGD 86 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 I ++ +V E L L+ D T L + QL+ + + HS Sbjct: 87 GIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT-FSLKTVLMIAIQLISRMEYVHSK 145 Query: 122 RVLHRDLKPQNLLINTEG-----AIKLADFGLARAF-------GVPVRTYTHEVVTLWYR 169 +++RD+KP+N LI G I + DF LA+ + +P R + T Y Sbjct: 146 NLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYM 205 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLG-----TPDE 224 + LG K S D+ +LG +F + + G + D L ++ +G TP E Sbjct: 206 SINTHLG-KEQSRRDDLEALGHMFMYFLRGSLPWQGL-KADTLKERYQKIGDTKRATPIE 263 Query: 225 VVWPGVTSMPDY 236 V+ M Y Sbjct: 264 VLCENFPEMATY 275 >5J0A-A nrPDB Length = 300 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 62/299 (20%), Positives = 107/299 (35%), Gaps = 35/299 (11%) Query: 6 KVEKIGEGTYGV---VYKARNKLTGE---VVALKKIR---LDTETEGVPSTAIREISLLK 56 ++K+G +G VY + G A+KKI D + E +LK Sbjct: 13 FMQKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILK 69 Query: 57 ELNHPNIVKLLDVIH-TENKLYLVFEFL-HQDLKKFMDAS---ALTGIPLPLIKSYLFQL 111 L+HPNIV + L L E+ + L ++ + P +I + Sbjct: 70 SLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNM 129 Query: 112 LQGLAFCHS-HRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHE---VVTL 166 +GL + H ++LH D+K N++I + IK+ D G++ + E + T Sbjct: 130 ARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTE 189 Query: 167 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVV 226 ++ E + + DI++ G EM+T I+ T DE Sbjct: 190 PWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP-----HINLSNDDDDEDKTFDESD 244 Query: 227 WPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAK---AALA 282 + Y + + ++ + L S + DP R SA AL Sbjct: 245 FDDEA----YYAALGTRPPINMEELDESY-QKVIELFSVCTNEDPKDRPSAAHIVEALE 298 >4BTK-A nrPDB Length = 337 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 53/229 (23%), Positives = 93/229 (40%), Gaps = 16/229 (6%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ ++KIG G +G +Y+A + LT E VALK + E+++LK+L Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV----ESAQQPKQVLKMEVAVLKKLQGK 111 Query: 62 -NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 ++ + + E Y+V + ++L + L Q+L+ + HS Sbjct: 112 DHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 171 Query: 121 HRVLHRDLKPQNL----LINTEGAIKLADFGLARAFGV------PVRTYTHEVVTLWYRA 170 LHRD+KP N L +T + DFGLAR + P R T+ Y + Sbjct: 172 VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYAS 231 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTL 219 + D+WSL + E + + + +Q+ I Sbjct: 232 VNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKY 279 >4NFN-A nrPDB Length = 309 Score = 144 bits (364), Expect = 4e-35, Method: Composition-based stats. Identities = 53/229 (23%), Positives = 93/229 (40%), Gaps = 16/229 (6%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + ++ ++KIG G +G +Y+A + LT E VALK + E+++LK+L Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV----ESAQQPKQVLKMEVAVLKKLQGK 76 Query: 62 -NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 ++ + + E Y+V + ++L + L Q+L+ + HS Sbjct: 77 DHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 136 Query: 121 HRVLHRDLKPQNL----LINTEGAIKLADFGLARAFGV------PVRTYTHEVVTLWYRA 170 LHRD+KP N L +T + DFGLAR + P R T+ Y + Sbjct: 137 VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYAS 196 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTL 219 + D+WSL + E + + + +Q+ I Sbjct: 197 VNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKY 244 >4TN6-A nrPDB Length = 318 Score = 143 bits (361), Expect = 9e-35, Method: Composition-based stats. Identities = 63/279 (22%), Positives = 109/279 (39%), Gaps = 21/279 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++ KIG G++G +Y + GE VA+K L+ P I E + K + Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK---LECVKTKHPQLHI-ESKIYKMMQGG 62 Query: 62 NIVKLLDVIHTENKL-YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 + + E +V E L L+ + + L + Q++ + + HS Sbjct: 63 VGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRK-FSLKTVLLLADQMISRIEYIHS 121 Query: 121 HRVLHRDLKPQNLLI---NTEGAIKLADFGLARAF-------GVPVRTYTHEVVTLWYRA 170 +HRD+KP N L+ + + DFGLA+ + +P R + T Y + Sbjct: 122 KNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYAS 181 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPG---DSEIDQLFRI-FRTLGTPDEVV 226 LG + S D+ SLG + + G ++ + RI + + TP EV+ Sbjct: 182 INTHLGIEQ-SRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL 240 Query: 227 WPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQ 265 G S +F + R D L + R+L + Sbjct: 241 CKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHR 279 >2CMW-A nrPDB Length = 310 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 60/258 (23%), Positives = 106/258 (41%), Gaps = 23/258 (8%) Query: 5 QKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH--PN 62 + +KIG G +G + +N T E VA+K L+ P + E K+L Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL-EYRFYKQLGSAGEG 58 Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122 + ++ +V E L L+ D T L + QLL + + HS Sbjct: 59 LPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT-FTLKTVLMIAIQLLSRMEYVHSKN 117 Query: 123 VLHRDLKPQNLLINTEG-----AIKLADFGLARAF-------GVPVRTYTHEVVTLWYRA 170 +++RD+KP+N LI +G I + DFGLA+ + +P R + T Y + Sbjct: 118 LIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMS 177 Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEV--VWP 228 LG K S D+ +LG +F + + G + D L ++ +G + Sbjct: 178 INTHLG-KEQSRRDDLEALGHMFMYFLRGSLPWQGL-KADTLKERYQKIGDTKRNTPIEA 235 Query: 229 GVTSMPDYKPSFPKWARQ 246 + P+ ++ ++ R+ Sbjct: 236 LCENFPEEMATYLRYVRR 253 >2C47-A nrPDB Length = 313 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 63/262 (24%), Positives = 112/262 (42%), Gaps = 28/262 (10%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH-P 61 NF+ +KIG G +G + +N T E VA+K L+ P + E K+L+ Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL-EYRFYKQLSATE 60 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 + ++ +V E L L+ D T L + QL+ + + H+ Sbjct: 61 GVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRT-FTLKTVLMIAIQLITRMEYVHTK 119 Query: 122 RVLHRDLKPQNLLINTEGA-----IKLADFGLARAF-------GVPVRTYTHEVVTLWYR 169 +++RD+KP+N L+ G I + DFGLA+ + +P R + T Y Sbjct: 120 SLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 179 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLG-----TPDE 224 + LG K S D+ +LG +F + + G + D L ++ +G TP E Sbjct: 180 SINTHLG-KEQSRRDDLEALGHMFMYFLRGSLPWQGL-KADTLKERYQKIGDTKRATPIE 237 Query: 225 VVWPGVTSMPDYKPSFPKWARQ 246 V+ + P+ ++ ++ R+ Sbjct: 238 VLCE---NFPEEMATYLRYVRR 256 >5FQD-C nrPDB Length = 341 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 61/250 (24%), Positives = 105/250 (42%), Gaps = 31/250 (12%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH-- 60 ++ V KIG G++G +Y A N GE VA+K L+++ P + E L K L Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVK---LESQKARHPQ-LLYESKLYKILQGGV 75 Query: 61 --PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118 P+I + ++ LV + L L+ + + + + Q++ + + Sbjct: 76 GIPHI-RWYG--QEKDYNVLVMDLLGPSLEDLFNFCSRR-FTMKTVLMLADQMISRIEYV 131 Query: 119 HSHRVLHRDLKPQNLLINTEGAI---KLADFGLARAF-------GVPVRTYTHEVVTLWY 168 H+ +HRD+KP N L+ L DFGLA+ + +P R + T Y Sbjct: 132 HTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARY 191 Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGD-----SEIDQLFRI-FRTLGTP 222 + LG + S D+ SLG + M R P ++ + +I + + TP Sbjct: 192 ASINAHLGIEQ-SRRDDMESLGYVL--MYFNRTSLPWQGLKAATKKQKYEKISEKKMSTP 248 Query: 223 DEVVWPGVTS 232 EV+ G + Sbjct: 249 VEVLCKGFPA 258 >3VHK-A nrPDB Length = 368 Score = 141 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 42/181 (23%), Positives = 76/181 (41%), Gaps = 10/181 (5%) Query: 96 LTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--G 153 + L + Y FQ+ +G+ F S + +HRDL +N+L++ + +K+ DFGLAR Sbjct: 194 KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKD 253 Query: 154 VPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQL 212 + L + APE + + Y+ D+WS G + E+ + + +PG + Sbjct: 254 PDYVRKGDARLPLKWMAPETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDE-- 310 Query: 213 FRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPN 272 R L + P T+ Y+ W + + P E L +L + Sbjct: 311 -EFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQR--PTFSELVEHL-GNLLQANAQ 366 Query: 273 K 273 + Sbjct: 367 Q 367 Score = 74.5 bits (182), Expect = 5e-14, Method: Composition-based stats. Identities = 24/117 (20%), Positives = 48/117 (41%), Gaps = 9/117 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKA----RNK-LTGEVVALKKIRLDTETEGVPSTAIREISLLK 56 + + + +G G +G V +A +K T VA+K ++ + T + E+ +L Sbjct: 29 DRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-EGATHSEHRALMSELKILI 87 Query: 57 ELNHP-NIVKLLDVIHTE-NKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQ 110 + H N+V LL L ++ EF +L ++ + +P + Q Sbjct: 88 HIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQ 144 >5X1R-A nrPDB Length = 302 Score = 140 bits (353), Expect = 9e-34, Method: Composition-based stats. Identities = 48/222 (21%), Positives = 79/222 (35%), Gaps = 21/222 (9%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-------------------RLDTETE 42 F+ E IGEG +G+VY+A + +A+K+ R + Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 43 GVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLP 102 ++ I+E LL +HP ++ +L Y+ +F K + A I Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDEA 140 Query: 103 LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE 162 I+ L L + H LHRD+ N+ I L DFG AR + T Sbjct: 141 WIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDETEI 200 Query: 163 VVTLWYRAPEILLGC--KYYSTAVDIWSLGCIFAEMVTRRAL 202 V+ + E DI++LG + ++ Sbjct: 201 VLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP 242 >5X18-A nrPDB Length = 295 Score = 139 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 62/276 (22%), Positives = 107/276 (38%), Gaps = 20/276 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH-P 61 +++ +KIGEG++GV+++ N + G VA+K TE + E K LN P Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRD----EYKTYKILNGTP 63 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 NI LV + L L+ D + + Q++ + H+H Sbjct: 64 NIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRK-FSVKTVVQVAVQMITLIEDLHAH 122 Query: 122 RVLHRDLKPQNLLINTEGA-----IKLADFGLARAF-------GVPVRTYTHEVVTLWYR 169 +++RD+KP N LI G I L DFG+A+ + +P R T Y Sbjct: 123 DLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYM 182 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRT-LGTPDEVVWP 228 + LG + S D+ +LG +F + + G + + + V+ Sbjct: 183 SINTHLG-REQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRSTNVYD 241 Query: 229 GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLS 264 +P + + R + P + + LLS Sbjct: 242 LAQGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLS 277 >4NT4-A nrPDB Length = 312 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 68/290 (23%), Positives = 118/290 (40%), Gaps = 39/290 (13%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NH- 60 NF+ +KIG G +G + +N E VA+K + P + E K L +H Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM---EPMKSKAPQLHL-EYRFYKLLGSHA 68 Query: 61 ---PNIVKLLDVIHTENKLY--LVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 P+ + + + T Y +V E L L+ + A L + QLL + Sbjct: 69 DNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARK-FSLKTVLMIAKQLLHRI 127 Query: 116 AFCHSHRVLHRDLKPQNLLI-----NTEGAIKLADFGLARAF-------GVPVRTYTHEV 163 + HS +++RD+KP+N LI E I + DFGLA+ + +P R + Sbjct: 128 EYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLT 187 Query: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLG--- 220 T Y + +G + S D+ +LG +F + + G + D L ++ +G Sbjct: 188 GTARYMSINTHMG-REQSRRDDLEALGHMFMYFLRGSLPWQGL-KADTLKERYQKIGDTK 245 Query: 221 --TPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLH 268 TP EV+ G P+ ++ ++ R+ P L ++ Sbjct: 246 RATPIEVLCDGH---PEEFATYLRYVRRLDFFETPDY-----DFLRRLFQ 287 >4M69-B nrPDB Length = 283 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 52/279 (18%), Positives = 100/279 (35%), Gaps = 43/279 (15%) Query: 16 GVVYKARNKLTGEVVALKKIRLDTETE--GVPSTAIREISLLKELNHPNIVKLLDVIHTE 73 +Y+ + V +K V T EI +K+ + PNI+++ + + Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 74 N----KLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 128 + +V E+ L++ +D + + + + + +GL H LHR++ Sbjct: 81 TVKPPEFSIVMEYCELGTLRELLDREK--DLTMSVRSLLVLRAARGLYRLHHSETLHRNI 138 Query: 129 KPQNLLINTEGAIKLADFGLARAFGVPVRTYTH----EVVTLWYRAPEILLGCK-YYSTA 183 + L+ +KLA F L++ RT + Y +PE L Y Sbjct: 139 SSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIK 198 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW 243 +I+S G + E+ T + F G + R L D+ P P Sbjct: 199 AEIYSFGIVLWEIATGKIPFEGCDS-----KKIRELVAEDKKQEPVGQDCP--------- 244 Query: 244 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 282 E R ++++ ++P++R S L Sbjct: 245 -------------ELLREIINECRAHEPSQRPSVDGILE 270 >4BTF-A nrPDB Length = 469 Score = 137 bits (346), Expect = 5e-33, Method: Composition-based stats. Identities = 52/279 (18%), Positives = 100/279 (35%), Gaps = 43/279 (15%) Query: 16 GVVYKARNKLTGEVVALKKIRLDTETE--GVPSTAIREISLLKELNHPNIVKLLDVIHTE 73 +Y+ + V +K V T EI +K+ + PNI+++ + + Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 74 N----KLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 128 + +V E+ L++ +D + + + + + +GL H LHR++ Sbjct: 267 TVKPPEFSIVMEYCELGTLRELLDREK--DLTMSVRSLLVLRAARGLYRLHHSETLHRNI 324 Query: 129 KPQNLLINTEGAIKLADFGLARAFGVPVRTYTH----EVVTLWYRAPEILLGCK-YYSTA 183 + L+ +KLA F L++ RT + Y +PE L Y Sbjct: 325 SSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIK 384 Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW 243 +I+S G + E+ T + F G + R L D+ P P Sbjct: 385 AEIYSFGIVLWEIATGKIPFEGCDS-----KKIRELVAEDKKQEPVGQDCP--------- 430 Query: 244 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 282 E R ++++ ++P++R S L Sbjct: 431 -------------ELLREIINECRAHEPSQRPSVDGILE 456 >3HNG-A nrPDB Length = 360 Score = 136 bits (342), Expect = 1e-32, Method: Composition-based stats. Identities = 50/198 (25%), Positives = 80/198 (40%), Gaps = 14/198 (7%) Query: 70 IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLK 129 + L V E +D F I + + SY FQ+ +G+ F S + +HRDL Sbjct: 173 FQEDKSLSDVEE--EEDSDGFYK----EPITMEDLISYSFQVARGMEFLSSRKCIHRDLA 226 Query: 130 PQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIW 187 +N+L++ +K+ DFGLAR + L + APE + K YST D+W Sbjct: 227 ARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFD-KIYSTKSDVW 285 Query: 188 SLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ 246 S G + E+ + + +PG + R + P ++ Y+ W R Sbjct: 286 SYGVLLWEIFSLGGSPYPGVQMDEDFCSRLR---EGMRMRAPEYSTPEIYQIMLDCWHRD 342 Query: 247 DFSK-VVPPLDEDGRSLL 263 + L E LL Sbjct: 343 PKERPRFAELVEKLGDLL 360 Score = 73.7 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 47/115 (40%), Gaps = 9/115 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKA-----RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLK 56 E + + +G G +G V +A + T VA+K ++ + T + E+ +L Sbjct: 27 ERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLK-EGATASEYKALMTELKILT 85 Query: 57 ELNHP-NIVKLLDVIHTE-NKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYL 108 + H N+V LL + L ++ E+ + +L ++ + ++ Sbjct: 86 HIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHM 140 >4RT7-A nrPDB Length = 415 Score = 134 bits (338), Expect = 5e-32, Method: Composition-based stats. Identities = 44/209 (21%), Positives = 87/209 (41%), Gaps = 29/209 (13%) Query: 50 REISLLKELNHPN---IVKLLD-VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIK 105 RE+ + HP+ I L H+E+++ E+ ++ K+ + L + + Sbjct: 198 REVQI-----HPDSDQISGLHGNSFHSEDEI----EY--ENQKRLEEEEDLNVLTFEDLL 246 Query: 106 SYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT--YTHEV 163 + +Q+ +G+ F +HRDL +N+L+ +K+ DFGLAR + Sbjct: 247 CFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNAR 306 Query: 164 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTP 222 + + + APE L Y+ D+WS G + E+ + +PG +++ + Sbjct: 307 LPVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKM 365 Query: 223 DE----------VVWPGVTSMPDYKPSFP 241 D+ ++ +PSFP Sbjct: 366 DQPFYATEEIYIIMQSCWAFDSRKRPSFP 394 Score = 90.7 bits (224), Expect = 6e-19, Method: Composition-based stats. Identities = 26/103 (25%), Positives = 47/103 (45%), Gaps = 8/103 (7%) Query: 2 ENFQKVEKIGEGTYGVVYKARN---KLTG--EVVALKKIRLDTETEGVPSTAIREISLLK 56 EN + + +G G +G V A TG VA+K ++ + + E+ ++ Sbjct: 65 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSELKMMT 123 Query: 57 EL-NHPNIVKLLDVIHTENKLYLVFEF-LHQDLKKFMDASALT 97 +L +H NIV LL +YL+FE+ + DL ++ + Sbjct: 124 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREK 166 >4MWI-A nrPDB Length = 294 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 53/267 (19%), Positives = 92/267 (34%), Gaps = 43/267 (16%) Query: 30 VALKKIRLDTETEG--VPSTAIREISLLKELNHPNIVKLLDVIHTEN----KLYLVFEFL 83 VA+K + V T +EI +K+ PNI+++ + E + +V E+ Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYC 109 Query: 84 H-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV--LHRDLKPQNLLINTEGA 140 L++ +D + L + +GL H LH ++ N L+ Sbjct: 110 ELGTLRELLDREK--DLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQ 167 Query: 141 IKLADFGLARAFGV----PVRTYTHEVVTLWYRAPEILLGCKY-YSTAVDIWSLGCIFAE 195 +KLA F L + R T V + Y +P+ L Y Y +I+S G + E Sbjct: 168 VKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWE 227 Query: 196 MVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPL 255 + T F G E + V +P + Sbjct: 228 IATGDIPFQG---------------CNSEKIRKLVAVKRQQEP------------LGEDC 260 Query: 256 DEDGRSLLSQMLHYDPNKRISAKAALA 282 + R ++ + +DP+ R S L Sbjct: 261 PSELREIIDECRAHDPSVRPSVDEILK 287 >1CSN-A nrPDB Length = 298 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 105/281 (37%), Gaps = 21/281 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH-P 61 +++ +IGEG++GV+++ N L + VA+K ++ + R LL P Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDE-YRTYKLLAGCTGIP 69 Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 N+ LV + L L+ +D + + Q+L + H Sbjct: 70 NV---YYFGQEGLHNVLVIDLLGPSLEDLLDLCGRK-FSVKTVAMAAKQMLARVQSIHEK 125 Query: 122 RVLHRDLKPQNLLINTEGA-----IKLADFGLARAF-------GVPVRTYTHEVVTLWYR 169 +++RD+KP N LI + I + DFG+ + + +P R + T Y Sbjct: 126 SLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYM 185 Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 + LG + S D+ +LG +F + + G + R Sbjct: 186 SINTHLG-REQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTPLRE 244 Query: 230 VTS-MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHY 269 + + P+ + +AR P D + L S++L Sbjct: 245 LCAGFPEEFYKYMHYARNLAFDATPDYDY-LQGLFSKVLER 284 >4JRN-A nrPDB Length = 372 Score = 128 bits (321), Expect = 4e-30, Method: Composition-based stats. Identities = 58/316 (18%), Positives = 100/316 (31%), Gaps = 75/316 (23%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTE-TEGVPSTAIREISLLKELN--------- 59 +G G + VY+A + T E +A+K + E T+ RE S + + Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 60 -------HPNIVKLLD-----------VIHTENKLYLVFEFLHQDLKKFMD------ASA 95 ++V L +L+ D+ K + + Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVN 195 Query: 96 LTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP 155 + L + Q ++ +A + ++H D+KP N L+ +G + L DFG R Sbjct: 196 KSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRI---- 251 Query: 156 VRTYTHEVVTLWYRAPEILLGCKY--YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLF 213 + + T Y PE Y+ D W LG + + P D D L Sbjct: 252 NNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYLH 311 Query: 214 RIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNK 273 P E + L+ +L+ DP K Sbjct: 312 -----------------------------------FADCPSTPELVQDLIRSLLNRDPQK 336 Query: 274 RISAKAALAHPFFQDV 289 R+ AL F+++ Sbjct: 337 RMLPLQALETAAFKEM 352 >2PZI-A nrPDB Length = 681 Score = 128 bits (321), Expect = 4e-30, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 108/285 (37%), Gaps = 52/285 (18%) Query: 3 NFQKVEKIGEGTYGVVYKARNKL-TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++ I G G +Y A ++ G V LK + + E L E+ HP Sbjct: 81 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE-RQFLAEVVHP 139 Query: 62 NIVKLLDVIHTENKL-----YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 +IV++ + + ++ Y+V E++ + S +P+ +YL ++L L+ Sbjct: 140 SIVQIFNFVEHTDRHGDPVGYIVMEYVGGQS---LKRSKGQKLPVAEAIAYLLEILPALS 196 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 + HS +++ DLKP+N+++ E +KL D G Y T ++APEI+ Sbjct: 197 YLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQAPEIVRT 251 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 + A DI+++G A + T +D +P+ Sbjct: 252 GP--TVATDIYTVGRTLAAL-TLDLPTRNGRYVD---------------------GLPED 287 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281 P + LL + + DP +R + + Sbjct: 288 DPVLKTYDSYGR-------------LLRRAIDPDPRQRFTTAEEM 319 >4Y12-A nrPDB Length = 375 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 108/285 (37%), Gaps = 52/285 (18%) Query: 3 NFQKVEKIGEGTYGVVYKARNKL-TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 ++ I G G +Y A ++ G V LK + + E L E+ HP Sbjct: 120 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE-RQFLAEVVHP 178 Query: 62 NIVKLLDVIHTENKL-----YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116 +IV++ + + ++ Y+V E++ + S +P+ +YL ++L L+ Sbjct: 179 SIVQIFNFVEHTDRHGDPVGYIVMEYVGGQS---LKRSKGQKLPVAEAIAYLLEILPALS 235 Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176 + HS +++ DLKP+N+++ E +KL D G Y T ++APEI+ Sbjct: 236 YLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQAPEIVRT 290 Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236 + A DI+++G A + T +D +P+ Sbjct: 291 GP--TVATDIYTVGRTLAAL-TLDLPTRNGRYVD---------------------GLPED 326 Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281 P + LL + + DP +R + + Sbjct: 327 DPVLKTYDSYGR-------------LLRRAIDPDPRQRFTTAEEM 358 >4XHH-A nrPDB Length = 403 Score = 126 bits (318), Expect = 9e-30, Method: Composition-based stats. Identities = 55/275 (20%), Positives = 103/275 (37%), Gaps = 21/275 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 F+ KIG G++G +Y N ++GE VA+ RL++ P E + K L+ Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQ-LDYESRVYKYLSGGV 63 Query: 63 IVKLLDVIHTENKLY-LVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 + + E + +V + L L+ + + Q++ + + H Sbjct: 64 GIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYC-HRKFSFKTVIMLALQMICRVQYIHGR 122 Query: 122 RVLHRDLKPQNLLIN---TEGAIKLADFGLARAF-------GVPVRTYTHEVVTLWYRAP 171 +HRD+KP N L+ + + DFGL++ + +P R T Y + Sbjct: 123 SFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASV 182 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPG---DSEIDQLFRIF-RTLGTPDEVVW 227 LG + S D+ SLG + + G ++ + RI + L E + Sbjct: 183 NTHLGIEQ-SRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCISVETLC 241 Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSL 262 G+ ++ + + D L + L Sbjct: 242 AGLPLEFSEYMNYCRNLKFDERPDYLYLARLFKDL 276 >5L2Q-C nrPDB Length = 320 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 54/302 (17%), Positives = 105/302 (34%), Gaps = 65/302 (21%) Query: 19 YKARNKLTGEVVALKKIRLDTE-TEGVPSTAIR--------EISLLKELN-HPNIVKLLD 68 AR T + LK + L+ +G+ S R E SLL L+ +V Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 69 VIHT------------------ENKLYLVFE-FLHQDLKK----FMDAS----ALTGIPL 101 + + ++ LV + D ++ + Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 102 PLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA-IKLADFGLARAFGVPVRTYT 160 + +++ + H ++HRDLK N+++N I + +F L + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 161 HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLG 220 + + Y +P++L G Y D+W+LG + M+ + F DS +LFR + Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFY-DSIPQELFRKIKA-- 269 Query: 221 TPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA 280 ++P+ + E+ L+ ++L DP +R++A Sbjct: 270 --------AEYTIPEDG----------------RVSENTVCLIRKLLVLDPQQRLAAADV 305 Query: 281 LA 282 L Sbjct: 306 LE 307 >4XHL-A nrPDB Length = 394 Score = 124 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 55/279 (19%), Positives = 104/279 (37%), Gaps = 21/279 (7%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 F+ KIG G++G +Y N ++GE VA+ RL++ P E + + L+ Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQ-LDYESRVYRYLSGGV 63 Query: 63 IVKLLDVIHTENKLY-LVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 + + E + +V + L L+ + + Q+ + + H Sbjct: 64 GIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRR-FSFKTVIMLALQMFCRIQYIHGR 122 Query: 122 RVLHRDLKPQNLLIN---TEGAIKLADFGLARAF-------GVPVRTYTHEVVTLWYRAP 171 +HRD+KP N L+ + + DFGL++ + +P R T Y + Sbjct: 123 SFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASV 182 Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPG---DSEIDQLFRIF-RTLGTPDEVVW 227 LG + S D+ SLG + + G ++ + RI + L E + Sbjct: 183 NTHLGIEQ-SRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETLC 241 Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQM 266 G+ ++ K + D L + L ++ Sbjct: 242 SGLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDLSIKL 280 >5USZ-A nrPDB Length = 289 Score = 124 bits (312), Expect = 5e-29, Method: Composition-based stats. Identities = 53/291 (18%), Positives = 106/291 (36%), Gaps = 52/291 (17%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGE-------VVALKKIRLDTETEGVPSTAIREISL 54 E+ E +G+GT+ ++K + G+ V LK + D + S+ Sbjct: 8 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFEAASM 65 Query: 55 LKELNHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQ 113 + +L+H ++V V ++ LV EF+ L ++ + I + QL Sbjct: 66 MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNK-NCINILWKLEVAKQLAA 124 Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGA--------IKLADFGLARAFGVPVRTYTHEVVT 165 + F + ++H ++ +N+L+ E IKL+D G++ +P + Sbjct: 125 AMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITV-LPKDILQERI-- 181 Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEV 225 + PE + K + A D WS G E+ + G Sbjct: 182 -PWVPPECIENPKNLNLATDKWSFGTTLWEICSG--------------------GDKPLS 220 Query: 226 VWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS 276 + Y +D ++ P + +L++ + Y+P+ R S Sbjct: 221 ALDSQRKLQFY---------EDRHQLPAPKAAELANLINNCMDYEPDHRPS 262 >5M07-A nrPDB Length = 276 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 41/205 (20%), Positives = 78/205 (38%), Gaps = 21/205 (10%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTE-TEGVPSTAIREISLLKELNHPN 62 + V +G G VY ++ ALK + + RE + L HP+ Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 I+++ D + +L++ +++ D + M +P+ + + + + L + H Sbjct: 92 ILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQR 151 Query: 122 RVLHRDLKPQNLLINT----EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177 +LHRD+ P N+++ + + I LADFG+A Y APE L Sbjct: 152 GLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ--------------PSYPAPE-LSAG 196 Query: 178 KYYSTAVDIWSLGCIFAEMVTRRAL 202 D ++L + Sbjct: 197 ADVDGRADQYALALTAIHLFAGAPP 221 >3REP-A nrPDB Length = 271 Score = 118 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 48/269 (17%), Positives = 101/269 (37%), Gaps = 45/269 (16%) Query: 16 GVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTEN- 74 G ++K R + VV K +++ + E L+ +HPN++ +L + Sbjct: 24 GELWKGRWQGNDIVV--KVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPA 81 Query: 75 -KLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS-HRVLHR-DLKP 130 L+ ++ + L + + + + +G+AF H+ ++ R L Sbjct: 82 PHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNS 141 Query: 131 QNLLINTEGAIKL--ADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS--TAVDI 186 ++++I+ + ++ AD + F P R Y + APE L + + D+ Sbjct: 142 RSVMIDEDMTARISMADVKFS--FQSPGRMYA-----PAWVAPEALQKKPEDTNRRSADM 194 Query: 187 WSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ 246 WS + E+VTR F S ++ ++ ++ +P+ P Sbjct: 195 WSFAVLLWELVTREVPFADLSNMEIGMKV----------------ALEGLRPTIP----- 233 Query: 247 DFSKVVPPLDEDGRSLLSQMLHYDPNKRI 275 P + L+ ++ DP KR Sbjct: 234 ------PGISPHVSKLMKICMNEDPAKRP 256 >5OAT-A nrPDB Length = 411 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 70/339 (20%), Positives = 113/339 (33%), Gaps = 94/339 (27%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGE-----VVALKKIRLDTETEGVPSTAIR----- 50 + + + I +GT GVVY A+ K ALK + E Sbjct: 10 LNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRET 69 Query: 51 ---------------EISLLKELNH----PNIVKLLDVIHT-----------------EN 74 EI L H PNIV + V Sbjct: 70 VPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNM 129 Query: 75 KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLL 134 L+L+ + +L+ F+ + T L L+ L +G+A +H + HRDLK NLL Sbjct: 130 SLFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLL----EGVAHMTAHGIAHRDLKSDNLL 185 Query: 135 INTEGA----IKLADFG--LARAFGVPVRTYTHE----VVTLWYRAPEIL-LGCKYYS-- 181 ++T + ++DFG LA YT APEI+ +S Sbjct: 186 LDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVL 245 Query: 182 --TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239 + D+W++G I E+ F G S + Sbjct: 246 NYSKADLWAVGAIAYEIFNCHNPFYGPS-----------------------------RLK 276 Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAK 278 + D K+ + ++L++ +L +PNKR+ + Sbjct: 277 NFNYKEGDLPKLPDEVPTVIQALVANLLKRNPNKRLDPE 315 >5C01-A nrPDB Length = 342 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 55/270 (20%), Positives = 97/270 (35%), Gaps = 43/270 (15%) Query: 21 ARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF 80 R++ V LK + D + SL+ +++H ++ + V + +V Sbjct: 101 GRDRGQELRVVLKVL--DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVT 158 Query: 81 EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA 140 E++ +P+ QL L++ + ++H ++ +N+L+ G Sbjct: 159 EYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGL 218 Query: 141 -------IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL-LGCKYYSTAVDIWSLGCI 192 IKL+D G G+ + V + + APE L G STA+D W G Sbjct: 219 AEGTSPFIKLSDPG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGAT 274 Query: 193 FAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVV 252 E+ F G++ P + P K F + + Sbjct: 275 LLEIC-----FDGEA--------------------PLQSRSPSEKEHFYQRQHRLPEPSC 309 Query: 253 PPLDEDGRSLLSQMLHYDPNKRISAKAALA 282 P L L SQ L Y+P +R S + L Sbjct: 310 PQLAT----LTSQCLTYEPTQRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 111 bits (278), Expect = 3e-25, Method: Composition-based stats. Identities = 55/270 (20%), Positives = 97/270 (35%), Gaps = 43/270 (15%) Query: 21 ARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF 80 R++ V LK + D + SL+ +++H ++ + V + +V Sbjct: 78 GRDRGQELRVVLKVL--DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVT 135 Query: 81 EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA 140 E++ +P+ QL L++ + ++H ++ +N+L+ G Sbjct: 136 EYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGL 195 Query: 141 -------IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL-LGCKYYSTAVDIWSLGCI 192 IKL+D G G+ + V + + APE L G STA+D W G Sbjct: 196 AEGTSPFIKLSDPG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGAT 251 Query: 193 FAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVV 252 E+ F G++ P + P K F + + Sbjct: 252 LLEIC-----FDGEA--------------------PLQSRSPSEKEHFYQRQHRLPEPSC 286 Query: 253 PPLDEDGRSLLSQMLHYDPNKRISAKAALA 282 P L L SQ L Y+P +R S + L Sbjct: 287 PQLAT----LTSQCLTYEPTQRPSFRTILR 312 >4L68-A nrPDB Length = 340 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 44/192 (22%), Positives = 79/192 (41%), Gaps = 14/192 (7%) Query: 16 GVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENK 75 G YKA G +A+K + + E++ L EL H N+ LL E + Sbjct: 54 GTTYKA-LLPDGSALAVKHLST---CKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEEE 109 Query: 76 LYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS---HRVLHRDLKPQ 131 +LV++++ + L +D++ + +GLA+ H +LH+++ Sbjct: 110 KFLVYKYMSNGTLHSLLDSNRGE-LDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSS 168 Query: 132 NLLINTEGAIKLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIW 187 +LI+ + ++ D GLAR T ++ Y APE S D++ Sbjct: 169 VILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPE-YSTTMLASLKGDVY 227 Query: 188 SLGCIFAEMVTR 199 LG + E+ T Sbjct: 228 GLGVVLLELATG 239 >6EQI-C nrPDB Length = 433 Score = 104 bits (260), Expect = 5e-23, Method: Composition-based stats. Identities = 64/349 (18%), Positives = 111/349 (31%), Gaps = 102/349 (29%) Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTG-----EVVALKKI---RLDTETEGVPSTAIRE- 51 ++ E I +G VVY A+ K +A+K + +++ + + RE Sbjct: 14 LDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRET 73 Query: 52 --------------ISLLKELN-----HPNIVKLLDVIHTENK----------------- 75 I + + HPNIV++ V Sbjct: 74 VPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRI 133 Query: 76 ----------LYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 125 L+LV + LK+++ + L QLL+ +A + H + H Sbjct: 134 NPEGSGRNMSLFLVMKRYDCTLKEYLRDKTPN---MRSSILLLSQLLEAVAHMNIHNISH 190 Query: 126 RDLKPQNLLINTEG-----AIKLADFGLA-----RAFGVPVRTYTHEV-VTLWYRAPEIL 174 RDLK N+L++ I + DFG +P R+ + APEI Sbjct: 191 RDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIA 250 Query: 175 LGC-KYYS----TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229 +S D+W++G I E+ F + Sbjct: 251 NAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKT---------------------- 288 Query: 230 VTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAK 278 K + +D ++ + R+L+S ML NKR+ Sbjct: 289 ------MKLLSKSYKEEDLPELPDTIPFIIRNLVSNMLSRSTNKRLDCD 331 >5UV4-A nrPDB Length = 311 Score = 102 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 46/203 (22%), Positives = 84/203 (41%), Gaps = 13/203 (6%) Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67 E IG +G YKA G ++ +K ++ REI L + HPN+V L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKS--KKEFSREIKKLGSVRHPNLVPLR 87 Query: 68 DVIH--TENKLYLVFEFLH-QDLKKFM---DASALTGIPLPLIKSYLFQLLQGLAFCHSH 121 E++ ++ ++ L ++ D L + + + + L + H+ Sbjct: 88 GYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNE 147 Query: 122 RVL-HRDLKPQNLLI-NTEGAIKLADFGLARAFG-VPVRTYTHEVVTLWYRAPEILLGCK 178 RV+ H ++K N+LI N+ + + D+ L R + + L Y PE K Sbjct: 148 RVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSK 207 Query: 179 YY-STAVDIWSLGCIFAEMVTRR 200 S D+++ G I E++T + Sbjct: 208 PCPSLKSDVYAFGVILLELLTGK 230 >4I94-A nrPDB Length = 300 Score = 99.5 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 46/264 (17%), Positives = 94/264 (35%), Gaps = 39/264 (14%) Query: 17 VVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKL 76 VVYK + +A+K+ + + + E + +L + + LL + + + Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWPDS--RQFLEEAKAVGQLRNHRMANLLGCCYEDEER 100 Query: 77 YLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR-VLHRDLKPQNLL 134 L+ EF+ ++ L K + + + + Q L +C S L+ DL +L Sbjct: 101 LLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRVL 160 Query: 135 INTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFA 194 + + +L+ FGL + T+ T PE L + + I+S G + Sbjct: 161 FDDDANPRLSCFGLMKNSRDGKSYSTNLAFTP----PEYLRTGRV-TPESVIYSFGTLLL 215 Query: 195 EMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPP 254 ++++ + + P + R + L D Sbjct: 216 DLLSGKHIPPSHALDLIRDRNIQML--------------------------MDSGLEGQF 249 Query: 255 LDEDGRSLLS---QMLHYDPNKRI 275 +DG L+ + L Y+P +R Sbjct: 250 SSDDGTELIRLASRCLQYEPRERP 273 >6J6I-B nrPDB Length = 351 Score = 98.0 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 34/192 (17%), Positives = 70/192 (36%), Gaps = 13/192 (6%) Query: 22 RNKLTGEVVALKKIRLD--TETEGVPSTAIREISLLKEL-NHPNIVKLLDVIHTENKLYL 78 R ++ +K+ D T +I L + NH N ++LL L Sbjct: 76 RGEIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVL 135 Query: 79 VFEFLHQDLKK----FMDASALTGIPLPLIKSYLFQLLQGLAFCHS---HRVLHRDLKPQ 131 VFEF + + +P + ++ + + H+ ++HRD+KP Sbjct: 136 VFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPM 195 Query: 132 NLLINTEGAIKLADFGLARAFGVPVRTYTHE--VVTLWYRAPEILLGCKYYSTAVDIWSL 189 ++ ++ KL+D + + E + T Y P + + + D++S Sbjct: 196 HVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSF 254 Query: 190 GCIFAEMVTRRA 201 G ++T + Sbjct: 255 GICLLVIITGKP 266 >4IX6-A nrPDB Length = 350 Score = 94.9 bits (235), Expect = 4e-20, Method: Composition-based stats. Identities = 63/328 (19%), Positives = 114/328 (34%), Gaps = 66/328 (20%) Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN----IVK 65 +G G +G V++ K + V LK + D E+ + + H N + Sbjct: 28 LGSGNFGTVFRGVFKGD-QDVVLKNAKADVM--AAEELLECEMDVNYHV-HANAKGTCAR 83 Query: 66 LLDVIH----TENKLY--LVFE---FL-----HQDLKKFMDASAL---------TGIPLP 102 + I ++Y + E + ++ M L Sbjct: 84 FMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATELG 143 Query: 103 LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTE--GAIKLADFGLARAFGVPVRTYT 160 + K + +LL LA H V+HRD+KP NL+ + G +KL D G A T Sbjct: 144 VTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETLN 203 Query: 161 HEVV-----TLWYRAPEILLGCKYYSTAV----------------DIWSLGCIFAEMVTR 199 + + +A E+ L D WS GC+ ++ Sbjct: 204 YYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLAV- 262 Query: 200 RALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDG 259 D+ +++ ++ +G D + G S ++ DF+ + G Sbjct: 263 -VGLRTDAGLERFLADYKAVGY-DVNAFRGEKS--------GEYGTMDFAALDANGGA-G 311 Query: 260 RSLLSQMLHYDPNKRISAKAALAHPFFQ 287 L +++ + + R S +AAL+H FF Sbjct: 312 WDLCQRLMEAERDARASCEAALSHAFFD 339 >5CLR-A nrPDB Length = 451 Score = 88.7 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 39/193 (20%), Positives = 73/193 (37%), Gaps = 21/193 (10%) Query: 19 YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKL-- 76 +K G+ LK +++D E+ + E L +L +L+ E Sbjct: 96 FKVYALDDGKTYFLKSVKIDAES---LTEFTNEKDTLSKLG-----RLVGTFFNEQTQVH 147 Query: 77 YLVFEFLHQ-DLKKFMDASALTGI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNL 133 Y++ F+ DL ++ +A L + + + + H ++HRDLKP N+ Sbjct: 148 YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNI 207 Query: 134 LINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI--LLGCKYYSTAVDIWSLGC 191 +++ + L DFG + T Y APE+ +S D+++L Sbjct: 208 MLDADMQCHLVDFGSS---SSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAY 264 Query: 192 IFAEMVTRRALFP 204 E+ F Sbjct: 265 SLDELFN---PFR 274 >5UU1-A nrPDB Length = 324 Score = 82.2 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 38/229 (16%), Positives = 77/229 (33%), Gaps = 34/229 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61 + +KIG G +G++Y A E A ++++ + G E+ + + Sbjct: 16 NQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP---LFSELKFYQRVAKK 72 Query: 62 NIVK---------------LLDV----IHTENKLYLVFEFLHQDLKKFMDASALTGIPLP 102 + +K + ++V E L DL+K + Sbjct: 73 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFKKS 130 Query: 103 LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLI--NTEGAIKLADFGLARAFGVPVRT-- 158 + ++L L + H + +H D+K NLL+ + LAD+GL+ + Sbjct: 131 TVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQ 190 Query: 159 -----YTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRAL 202 T+ + + + G S D+ LG + + Sbjct: 191 YQENPRKGHNGTIEFTSLDAHKGVAL-SRRSDVEILGYCMLRWLCGKLP 238 >2RSV-A nrPDB Length = 403 Score = 80.6 bits (198), Expect = 8e-16, Method: Composition-based stats. Identities = 43/242 (17%), Positives = 87/242 (35%), Gaps = 33/242 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVV------ALKKIRLDT----------ETEGVP 45 + ++ IG+G +G +Y A + + E V +K D + P Sbjct: 42 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 100 Query: 46 STAIREISLLKELNHPNIVKLLDVIHTEN----KLYLVFEFLHQDLKKFMDASALTGIPL 101 + I ++L + + K + +++ + DL+K +A+A Sbjct: 101 EQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA-KRFSR 158 Query: 102 PLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN--TEGAIKLADFGLA-----RAFGV 154 + ++L L + H H +H D+K NLL+N + L D+GLA Sbjct: 159 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 218 Query: 155 PVRTYTHEV--VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQL 212 + T+ + + + G S D+ LG + +T + + + + Sbjct: 219 EYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY 277 Query: 213 FR 214 R Sbjct: 278 VR 279 >4O1O-A nrPDB Length = 717 Score = 80.3 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 48/289 (16%), Positives = 94/289 (32%), Gaps = 76/289 (26%) Query: 16 GVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVKLLDVIHTEN 74 G +Y + VA+K+ + + +E+S L+ + N+V + Sbjct: 360 GGIYLG--LYEDQEVAVKRFSEGS------TRGQQEVSCLQSSRANDNVVTFYGSESDGS 411 Query: 75 KLYLVFEFLHQDLKKFMDASALTGIPLPL---IKSYLFQLLQGLAFCHSHRVLHRDLKPQ 131 L++ L++ + +P ++ L L + + H H+DL+PQ Sbjct: 412 CLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQ 471 Query: 132 NLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLG- 190 N+LI+++ LADF + + + D+ +LG Sbjct: 472 NILIDSKNGTFLADFDKSIKWAEDPQKIKR-----------------------DLEALGL 508 Query: 191 CIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSK 250 + + F + + ++ + Sbjct: 509 LVLYVVKKGDISFE----------------------------------TLKNQSFEEVIQ 534 Query: 251 VVPPLDEDGRSLLSQMLHY--DPNKRISAKAALAHPFFQDVTKPVPHLR 297 P DE+ R L+ + H + R+S+ LAHPFF LR Sbjct: 535 GSP--DEETRDLIHHLFHPGDNVEDRLSS--LLAHPFFWSWESRYRTLR 579 >2LAV-A nrPDB Length = 361 Score = 79.1 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 43/242 (17%), Positives = 87/242 (35%), Gaps = 33/242 (13%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVV------ALKKIRLDT----------ETEGVP 45 + ++ IG+G +G +Y A + + E V +K D + P Sbjct: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 Query: 46 STAIREISLLKELNHPNIVKLLDVIHTEN----KLYLVFEFLHQDLKKFMDASALTGIPL 101 + I ++L + + K + +++ + DL+K +A+A Sbjct: 94 EQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANA-KRFSR 151 Query: 102 PLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN--TEGAIKLADFGLA-----RAFGV 154 + ++L L + H H +H D+K NLL+N + L D+GLA Sbjct: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 Query: 155 PVRTYTHEV--VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQL 212 + T+ + + + G S D+ LG + +T + + + + Sbjct: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKDPKY 270 Query: 213 FR 214 R Sbjct: 271 VR 272 >4OAU-C nrPDB Length = 699 Score = 76.8 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 49/287 (17%), Positives = 91/287 (31%), Gaps = 71/287 (24%) Query: 16 GVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVKLLDVIHTEN 74 G +Y + VA+K EG P A RE+S L+ + ++V Sbjct: 357 GGIYLGF--YEKQEVAVKTF-----CEGSPR-AQREVSCLQSSRENSHLVTFYGSESHRG 408 Query: 75 KLYLVFEFLHQDLKKFMDASALTGIPLPL---IKSYLFQLLQGLAFCH-SHRVLHRDLKP 130 L++ Q L+ +D + ++ L + + + H S H+DL+P Sbjct: 409 HLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQP 468 Query: 131 QNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLG 190 QN+LI+++ A LADF + + + E+ + Sbjct: 469 QNILIDSKKAAHLADFDKSIKWAGDPQ--------------EVKRDLEDLGR-------- 506 Query: 191 CIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSK 250 + + F + ++ + Sbjct: 507 LVLYVVKKGSISFED----------------------------------LKAQSNEEVVQ 532 Query: 251 VVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR 297 + P DE+ + L+ ++ H + R L HPFF LR Sbjct: 533 LSP--DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLR 577 >4CI6-B nrPDB Length = 643 Score = 76.8 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 52/286 (18%), Positives = 92/286 (32%), Gaps = 47/286 (16%) Query: 24 KLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-----NHPNIVKLLD--VIHTENKL 76 K +VA E E+ K + HPN+ + V+ N+ Sbjct: 66 KDKQRLVA------KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRY 119 Query: 77 Y--LVFE-----FLHQDLKKFMDASALTGIPLP----LIKSYLFQLLQGLAFCHSHRVLH 125 Y L+ + L+ D+ I IK +LL ++H Sbjct: 120 YYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVH 179 Query: 126 RDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAV 184 D+KP N++ + G + D GL G + +T ++APE+ +G S Sbjct: 180 NDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGFTES-----FKAPELGVGNLGASEKS 234 Query: 185 DIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWA 244 D++ + + ++ F D EI + P V+ P ++P Sbjct: 235 DVF---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHVM--DENGYPIHRPGIAGVE 289 Query: 245 RQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290 ++ +L + R + A H F D T Sbjct: 290 TAYTR------------FITDILGVSADSRPDSNEARLHEFLSDGT 323 >6EAS-A nrPDB Length = 308 Score = 74.1 bits (181), Expect = 8e-14, Method: Composition-based stats. Identities = 44/288 (15%), Positives = 94/288 (32%), Gaps = 42/288 (14%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALK---KIRLDTETEGVPSTAIREISLLKEL 58 E+F + IG + ++YK +G +A+ ++ S ++I+ L ++ Sbjct: 42 EDFSNI--IGSTSTCMLYKGT-LSSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKV 98 Query: 59 NHPNIVKLLDVIHTENKL--YLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 +H N + LL E+ +VFE+ + L + + + + L Sbjct: 99 SHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCL 158 Query: 116 AFCHSHRV--LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 173 H + R+ + + + A K++D F + + +P++ Sbjct: 159 EHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDL----EFWNDAKGHNSTTNNELAFSPDM 214 Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVTRRAL-FPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232 + Y G + E++T R D ++ + G E + Sbjct: 215 EDIVRKY---------GMVLLEILTGRVPSSEDDGPLENWVSRYFEGGMRLEELIDPSIG 265 Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA 280 FP+ + +V + + DP KR K Sbjct: 266 F------FPEDTARALCEV-----------VRSCIDRDPKKRPQMKEV 296 >5DMZ-A nrPDB Length = 365 Score = 72.2 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 48/283 (16%), Positives = 94/283 (33%), Gaps = 42/283 (14%) Query: 10 IGEGTYGVVYKAR-----NKLTGEVVALKKIRLDTETEGVPSTAIREISLLK-ELNHPNI 63 +GEG + VY+A + + LK + E T + E LK + H Sbjct: 73 LGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER--LKPSMQHMF- 129 Query: 64 VKLLDVIHTENKLYLVFE-FLHQDLKK---FMDASALTGIPLPLIKSYLFQLLQGLAFCH 119 +K +N LV E + + L + +P L+ S+ ++L + H Sbjct: 130 MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVH 189 Query: 120 SHRVLHRDLKPQNLLINT-----------EGAIKLADFGLARAFGVPVRT--YTHEVVTL 166 ++H D+KP N ++ + L D G + + + +T + T Sbjct: 190 DCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETS 249 Query: 167 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVV 226 ++ E+L K ++ +D + + M+ + E + Sbjct: 250 GFQCVEMLSN-KPWNYQIDYFGVAATVYCMLFGTY----------MKVKNEGGECKPEGL 298 Query: 227 WPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHY 269 + + + + F +P L LL Q L Sbjct: 299 FRRLPHLDMWNEFFHVMLNIPDCHHLPSL-----DLLRQKLKK 336 >6G4J-A nrPDB Length = 315 Score = 70.2 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 43/226 (19%), Positives = 82/226 (36%), Gaps = 29/226 (12%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63 + +++G+G G+VY A G VALK + E+++LK + Sbjct: 28 YTLRKQLGKGANGIVYLA-ETSDGH-VALKV-------SDDSLSITSEVNVLKSFSKAQS 78 Query: 64 VKLLDVIHTENKLYL----------VFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQ 113 V + + Y+ E++ L + + G I + QLL Sbjct: 79 VTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPL--LLKYVSDKG--AEWIPVLMIQLLS 134 Query: 114 GLAFCHSHRVLHRDLKPQNLLINT-EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172 L+ H + DLKP NL++ I+ D G G ++ YT ++ Sbjct: 135 SLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGYWG--- 191 Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRT 218 G + + D++++ I V ++ + +QL + Sbjct: 192 --YGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIEG 235 >2JII-A nrPDB Length = 352 Score = 64.1 bits (155), Expect = 8e-11, Method: Composition-based stats. Identities = 29/171 (16%), Positives = 66/171 (38%), Gaps = 12/171 (7%) Query: 70 IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLK 129 +H + +LV L + L+ +D S + + +LL L F H + +H ++ Sbjct: 127 VHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVT 186 Query: 130 PQNLLIN--TEGAIKLADFGLARAFGVPVRTYTHEVVTL-------WYRAPEILLGCKYY 180 +N+ ++ + + LA +G A + + + + + + ++ GC Sbjct: 187 AENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP- 245 Query: 181 STAVDIWSLGCIFAEMVTRRALFPG--DSEIDQLFRIFRTLGTPDEVVWPG 229 S D+ SLG + + + + D + + + + P V P Sbjct: 246 SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPC 296 >6M7Z-A nrPDB Length = 319 Score = 59.1 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 34/202 (16%), Positives = 65/202 (32%), Gaps = 48/202 (23%) Query: 97 TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV 156 TG P ++ ++ L H+ +LHR ++ + + +G + L A G Sbjct: 139 TGRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLGGLDTAAPIGTET 198 Query: 157 RTYTHEVVTLWYRAPEI--------LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSE 208 R + APEI L ++ D++SLG Sbjct: 199 RLWVGFFG--QETAPEIDRNFLADLALTQGRHTVKSDVYSLGV----------------- 239 Query: 209 IDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLH 268 + + LG + P RQD +++ L +M+ Sbjct: 240 --AFRNLVQLLGN------------GNLGPEDRGAVRQDHLELLDKLS-------QKMIE 278 Query: 269 YDPNKRISAKAALAHPFFQDVT 290 +P R + + + P F+ + Sbjct: 279 EEPGNRPTIEEIMKDPLFEGLN 300 >4CYJ-A nrPDB Length = 438 Score = 58.7 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 33/140 (23%), Positives = 57/140 (40%), Gaps = 15/140 (10%) Query: 18 VYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTE--NK 75 VYKA+N G AL+ RL+ + + K++ + +IV + +V T Sbjct: 71 VYKAQNSRNGRHYALR--RLEGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTTREFGD 128 Query: 76 LYLVFEFLHQDLKKFMDASALTGI-----------PLPLIKSYLFQLLQGLAFCHSHRVL 124 L+F + L K + I P I Y+ Q+ L HS+R+ Sbjct: 129 SSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSNRLA 188 Query: 125 HRDLKPQNLLINTEGAIKLA 144 R L+P +++ I+L+ Sbjct: 189 ARCLEPSKIILTDINRIRLS 208 >5GZA-A nrPDB Length = 290 Score = 58.7 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 41/217 (18%), Positives = 67/217 (30%), Gaps = 50/217 (23%) Query: 5 QKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64 ++V+ IG+G VY + G+ VAL + D + +S+L+ L ++V Sbjct: 28 RRVKLIGQGAVKKVYLSE--WQGQKVALSVLSSDQYADDFLHG----LSMLRALQSSHVV 81 Query: 65 KLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQG----LAFCH 119 L+ V + V E+ + A QL LA+ H Sbjct: 82 TLVGVCEED--AVFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLH 139 Query: 120 SH--RV--------LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV----- 164 S + LH+ L L+ ++ + LA + Sbjct: 140 SSPAGIRVMCDSNDLHKTL--SQFLLASDMRL------LANDLDALPEVEKGGLGVKCGH 191 Query: 165 ---TLWYRAPEIL-----------LGCKYYSTAVDIW 187 T + APE L Y DIW Sbjct: 192 HELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >6EWX-A nrPDB Length = 484 Score = 57.5 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 43/259 (16%), Positives = 74/259 (28%), Gaps = 77/259 (29%) Query: 71 HTENKLYLVF-EFLHQDLKKFMDASALTGIPLPLI-----KSYLFQLLQGLAFCHSHRVL 124 ++ + ++ E HQ F+ S + P + L QL GL H ++ Sbjct: 173 QEQDCVVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGII 232 Query: 125 HRDLKPQNLLINTEG-----------------------------------------AIKL 143 HRDL +NLL+ + + Sbjct: 233 HRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLII 292 Query: 144 ADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALF 203 ++F A+ + APEI+ +Y D + G + E++ Sbjct: 293 SNFLKAKQKPGGTTNLQQKKSQAR-LAPEIVSASQY--RKFDEFQTGILIYELL--HQPN 347 Query: 204 PGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLL 263 P + R +R P + ++ Y P + L Sbjct: 348 PFEVRAQLRERDYRR------EDLPPLPTLSLYSPGLQQ-------------------LA 382 Query: 264 SQMLHYDPNKRISAKAALA 282 +L DP KRI A Sbjct: 383 HLLLEADPIKRIRIGEAKR 401 >5GZ9-A nrPDB Length = 305 Score = 56.4 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 33/211 (15%), Positives = 66/211 (31%), Gaps = 37/211 (17%) Query: 5 QKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64 ++++++GEG V+ + K VAL ++ E + +LK L ++V Sbjct: 37 RQLKRVGEGAVKRVFLSEWKE--HKVALSRLTRLEMKEDFLHG----LQMLKSLQSEHVV 90 Query: 65 KLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGI----PLPLIKSYLFQLLQGLAFCH 119 L+ + ++ E+ L + L+ + + + + H Sbjct: 91 TLVGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYLH 148 Query: 120 SHRVLHRDLKPQN--------LLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---- 167 + R + N L+ + +I D A + Sbjct: 149 HSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLD-ALPLVDHDSGVLIKCGHRELHGD 207 Query: 168 YRAPEILLGCK-----------YYSTAVDIW 187 + APE L Y+ VDIW Sbjct: 208 FVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >6G38-A nrPDB Length = 357 Score = 55.6 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 42/178 (23%), Positives = 63/178 (35%), Gaps = 50/178 (28%) Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD------TETEGVPSTAIREISLL 55 E Q+ EKIGEG +G V+ + VA+K I ++ + + EI + Sbjct: 41 EKLQRCEKIGEGVFGEVF--QTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIIS 98 Query: 56 KE-----------------LNHPNIVK------LLDV----------------IHTENKL 76 KE LN + V+ LL +++L Sbjct: 99 KELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQL 158 Query: 77 YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH-SHRVLHRDLKPQNL 133 ++V EF + ++ L KS L QL LA S R HRDL N+ Sbjct: 159 FIVLEFEFGGID--LEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >6BHC-A nrPDB Length = 438 Score = 55.2 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 49/298 (16%), Positives = 85/298 (28%), Gaps = 84/298 (28%) Query: 30 VALKKIRLDTETEG-------VPSTAIREISLLKELNH-----PN-IVKLLDVIHTENKL 76 A+K + + V + ++ ++ H PN ++ D + Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPSKKQRSH 145 Query: 77 YLVF----------EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126 +V +F+ L + + + L QL GL + V H Sbjct: 146 VVVITREVPCLTVADFVRDSLAQH---GKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHC 202 Query: 127 DLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWY------------------ 168 DL+ +NLL+ G A+ FG T T T Sbjct: 203 DLRLENLLLVHYQPG-----GTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEI 257 Query: 169 ------RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP 222 APEI+ +Y D + G + EM+ F Sbjct: 258 LRDQSRLAPEIITATQY--KKCDEFQTGILIYEMLHLPNPFD------------------ 297 Query: 223 DEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA 280 P + + P+ P + L S +L+ +P++RI A Sbjct: 298 ---ENPELKEREYTRADLPRIP------FRSPYSRGLQQLASCLLNPNPSERILISDA 346 >4AZW-A nrPDB Length = 471 Score = 53.7 bits (128), Expect = 9e-08, Method: Composition-based stats. Identities = 30/133 (22%), Positives = 45/133 (33%), Gaps = 19/133 (14%) Query: 27 GEVVALKK--------IRLDTETEGVPSTAIREISLLKE----LNHPNIVKLLDVIHTEN 74 GE K I E++ EI L + + P + L Sbjct: 259 GEDYVCKFFYYDMPHGILTAEESQRNKHELHNEIKFLTQPPAGFDAPAV---LAHGENAQ 315 Query: 75 KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLL 134 +LV E L L M A+ L LL+ LA H D++P N++ Sbjct: 316 SGWLVMEKLPGRLLSDMLAAGEEIDRE----KILGSLLRSLAALEKKGFWHDDVRPWNVM 371 Query: 135 INTEGAIKLADFG 147 ++ +L DFG Sbjct: 372 VDARQHARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 53.3 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 30/133 (22%), Positives = 45/133 (33%), Gaps = 19/133 (14%) Query: 27 GEVVALKK--------IRLDTETEGVPSTAIREISLLKE----LNHPNIVKLLDVIHTEN 74 GE K I E++ EI L + + P + L Sbjct: 259 GEDYVCKFFYYDMPHGILTAEESQRNKYELHNEIKFLTQPPAGFDAPAV---LAHGENAQ 315 Query: 75 KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLL 134 +LV E L L M A+ L LL+ LA H D++P N++ Sbjct: 316 SGWLVMEKLPGRLLSDMLAAGEEIDRE----KILGSLLRSLAALEKQGFWHDDVRPWNVM 371 Query: 135 INTEGAIKLADFG 147 ++ +L DFG Sbjct: 372 VDARQHARLIDFG 384 >4BWP-A nrPDB Length = 448 Score = 51.7 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 31/165 (18%), Positives = 58/165 (35%), Gaps = 41/165 (24%) Query: 19 YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHT----EN 74 Y+A + TG +R + + + + K+L H N+V+L +V T +N Sbjct: 67 YRATHNTTGYKY---CLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDN 123 Query: 75 KLYLVFEFLHQD---LKKFM---------------------------DASALTGIPLPLI 104 L LV+++ L K+ S +P I Sbjct: 124 SLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATI 183 Query: 105 KSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTE----GAIKLAD 145 S + QL GL H + + L P +++ + + ++D Sbjct: 184 WSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >5VE6-A nrPDB Length = 492 Score = 51.0 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 6/71 (8%) Query: 71 HTENKLYLVF-EFLHQDLKKFMDASALTGIPLPL-----IKSYLFQLLQGLAFCHSHRVL 124 ++ + ++ E HQ F+ SA + P + L QL GL H ++ Sbjct: 171 QEQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGII 230 Query: 125 HRDLKPQNLLI 135 HRDL +NLL+ Sbjct: 231 HRDLCLENLLL 241 Score = 36.0 bits (82), Expect = 0.019, Method: Composition-based stats. Identities = 22/114 (19%), Positives = 36/114 (31%), Gaps = 29/114 (25%) Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228 APEI+ +Y D + G + E++ P + R +R + P Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELL--HQPNPFEVRAQLRERDYR------QEDLP 374 Query: 229 GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 282 + ++ Y P + L +L DP KRI A Sbjct: 375 PLPALSLYSPGLQQ-------------------LAHLLLEADPIKRIRIGEAKR 409 >3ENH-A nrPDB Length = 540 Score = 51.0 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 27/167 (16%), Positives = 60/167 (35%), Gaps = 31/167 (18%) Query: 10 IGEGTYGVVYKARNKLTGEVVALK-KIRLDTETEGVPSTAI-----REISLLKELNH--- 60 IG+G + R+ V +K +++ E + RE L + Sbjct: 344 IGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGI 401 Query: 61 --PNIVKLLDVIHTENKLYLVFEFLHQDL-KKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 P I DV + ++ +++ L K ++ + +++ + + Sbjct: 402 PAPYI---FDVDLDNKR--IMMSYINGKLAKDVIEDN----------LDIAYKIGEIVGK 446 Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV 164 H + V+H DL N + + + + + DFGL + + +V Sbjct: 447 LHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDEDKAVDLIV 491 >3Q60-A nrPDB Length = 371 Score = 49.0 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 57/336 (16%), Positives = 101/336 (30%), Gaps = 76/336 (22%) Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62 + VE + G VV+ R+ E ALK + E + E + Sbjct: 63 KLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAAA----- 117 Query: 63 IVKLLD-------------------VIHTENKL--------------YLVF--------E 81 +LL + ++ YL+ E Sbjct: 118 --RLLGESPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLE 175 Query: 82 FLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI 141 L L GI I + QL++ A S ++H P NL I +G + Sbjct: 176 LLFSTLDFVYVFRGDEGILALHILT--AQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRL 233 Query: 142 KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK--YYSTAVDIWSLGCIFAEMVTR 199 L D ++ + V R V + AP L ++ A++ W LG + Sbjct: 234 MLGD--VSALWKVGTRGPASSVPVTY--APREFLNASTATFTHALNAWQLGLSIYRVWCL 289 Query: 200 RALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDG 259 F + + + PG S+ PL + Sbjct: 290 FLPFGLVTPG------IKGSWKRPSLRVPGTDSLAFGS--------------CTPLPDFV 329 Query: 260 RSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPH 295 ++L+ + L++D +R+ A+ P F + + Sbjct: 330 KTLIGRFLNFDRRRRLLPLEAMETPEFLQLQNEISS 365 >6R5K-O nrPDB Length = 689 Score = 47.9 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 28/135 (20%), Positives = 56/135 (41%), Gaps = 10/135 (7%) Query: 19 YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTEN---- 74 +K + G+ LK++ + + P+ + + ++N N++K D+ T Sbjct: 311 FKVFSNYDGKAYVLKRLP-NIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDL 369 Query: 75 KLYLVFEFLHQDLKKF-MDASALTGIPL--PLIKSYLFQLLQGLAFCHSHRV-LHRDLKP 130 + LVF++ L + P+ + YL QL + HS + + L Sbjct: 370 SICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLNW 429 Query: 131 QNLLINTE-GAIKLA 144 + +LI + G IKL+ Sbjct: 430 RKVLITGDPGRIKLS 444 >3BYV-A nrPDB Length = 377 Score = 47.9 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 40/268 (14%), Positives = 92/268 (34%), Gaps = 50/268 (18%) Query: 20 KARNKLTGEVV--------------ALKKIRLDTETEGVPS--TAIREISLLKELNHPNI 63 +A ++ TGE A+K+++ + + ++ + P Sbjct: 91 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 150 Query: 64 V-------KLLDVIHTENKLYLVFEF-----LHQDLKKF-----MDASALTGIPLPLIKS 106 + K++ V E ++++ F + +L+ F +S + Sbjct: 151 LVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQ 210 Query: 107 YLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTL 166 Q+++ LA H + ++H L+P +++++ G + L F V V+ Sbjct: 211 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF----EHLVRDGARVVSSVSR 266 Query: 167 WYRAPEI--LLGCKYY--------STAVDIWSLGCIFAEMVTRRALFPGDSEI---DQLF 213 + PE+ Y + + D W+LG + + D+ + + +F Sbjct: 267 GFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLPITKDAALGGSEWIF 326 Query: 214 RIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 R + + P + G P P Sbjct: 327 RSCKNIPQPVRALLEGFLRYPKEDRLLP 354 >4WWA-A nrPDB Length = 261 Score = 47.9 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 30/154 (19%), Positives = 54/154 (35%), Gaps = 30/154 (19%) Query: 19 YKARNKLTGEVVALKKIRLDTETEGV------PSTAIREISLLKELNHPNIV------KL 66 Y R K + + +K + E LL +L ++ +L Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKL---YLIPGLCVPQL 94 Query: 67 LDVIHTENKLYLVFEFLHQDL---------KKFMDASALTGIPLPLIKSYLFQLLQGLAF 117 + ++L EFL +DL K F+ L+ + L ++ + + Sbjct: 95 IACDPYNGFIWL--EFLGEDLPGGHGFSNLKNFLWMHDQDPYS-DLVATTLRKVGRQIGL 151 Query: 118 CHSHRVLHRDLKPQNLLINTEG---AIKLADFGL 148 H + H DL N+++ +G L DFGL Sbjct: 152 LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >4CZY-B nrPDB Length = 429 Score = 47.1 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 32/140 (22%), Positives = 56/140 (40%), Gaps = 17/140 (12%) Query: 19 YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHT----EN 74 YKA+N G AL++I + + K++ + NIV + + T ++ Sbjct: 61 YKAQNNKNGRHFALRRI--EGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGDS 118 Query: 75 KLYLVFEF--LHQDLKKFM--------DASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124 L V++F L + L IP L+ SY+ Q+ L H+ ++ Sbjct: 119 SLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKLA 178 Query: 125 HRDLKPQNLLINTEGAIKLA 144 R L+ + I I+LA Sbjct: 179 ARCLELSKI-IWENNRIRLA 197 >3DZO-A nrPDB Length = 413 Score = 46.7 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 39/267 (14%), Positives = 93/267 (34%), Gaps = 49/267 (18%) Query: 20 KARNKLTGEVV--------------ALKKIRLDTETEGVPS--TAIREISLLKELNHPNI 63 +A ++ TGE A+K+++ + + ++ + P Sbjct: 96 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 155 Query: 64 V-------KLLDVIHTENKLYLVFEF-----LHQDLKKF-----MDASALTGIPLPLIKS 106 + K++ V E ++++ F + +L+ F +S + Sbjct: 156 LVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQ 215 Query: 107 YLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTL 166 Q+++ LA H + ++H L+P +++++ G + L F + + Sbjct: 216 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF---EHLVRDGASAVSPIG-R 271 Query: 167 WYRAPE-----ILLGCKYY----STAVDIWSLGCIFAEMVTRRALFPGDSEI---DQLFR 214 + PE +L +++ + A D W+LG + D+ + + +FR Sbjct: 272 GFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDDAALGGSEWIFR 331 Query: 215 IFRTLGTPDEVVWPGVTSMPDYKPSFP 241 + + P + G P P Sbjct: 332 SCKNIPQPVRALLEGFLRYPKEDRLLP 358 >4XR7-L nrPDB Length = 465 Score = 46.0 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 28/135 (20%), Positives = 56/135 (41%), Gaps = 10/135 (7%) Query: 19 YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTEN---- 74 +K + G+ LK++ + + P+ + + ++N N++K D+ T Sbjct: 87 FKVFSNYDGKAYVLKRLP-NIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDL 145 Query: 75 KLYLVFEFLHQDLKKF-MDASALTGIPL--PLIKSYLFQLLQGLAFCHSHRV-LHRDLKP 130 + LVF++ L + P+ + YL QL + HS + + L Sbjct: 146 SICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLNW 205 Query: 131 QNLLINTE-GAIKLA 144 + +LI + G IKL+ Sbjct: 206 RKVLITGDPGRIKLS 220 >2W1Z-A nrPDB Length = 368 Score = 43.3 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 25/164 (15%), Positives = 55/164 (33%), Gaps = 16/164 (9%) Query: 90 FMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLA 149 +S + QL++ A + ++H D + +N+L++ G + L F Sbjct: 179 LSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLTGF--- 235 Query: 150 RAFGVPVRTYTHEVVTLWYRAPE-----ILLGCKYY----STAVDIWSLGCIFAEMVTRR 200 + + + PE +L +++ + D W+LG + Sbjct: 236 EHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCAD 294 Query: 201 ALFPGDSE---IDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241 D+E I+ ++R + + P + G P Sbjct: 295 LPNTEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYSKEDRLLP 338 >1TQM-A nrPDB Length = 282 Score = 38.6 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 31/156 (19%), Positives = 60/156 (38%), Gaps = 28/156 (17%) Query: 6 KVEKIGEGTYGVVYKARNKLTGEVVA---------LKKIRLDTETEGVP------STAIR 50 + +GEG V+ ++ GE V KK++ + + +A Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 51 EISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ 110 E L++L + K+ + L + +DA L + + L Sbjct: 154 EFRALQKLQGLAVPKVYAWEG------------NAVLMELIDAKELYRVRVENPDEVLDM 201 Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADF 146 +L+ +A + ++H DL N+L++ EG I + DF Sbjct: 202 ILEEVAKFYHRGIVHGDLSQYNVLVSEEG-IWIIDF 236 >6FAI-l nrPDB Length = 425 Score = 34.4 bits (78), Expect = 0.062, Method: Composition-based stats. Identities = 23/170 (13%), Positives = 48/170 (28%), Gaps = 37/170 (21%) Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL---------------DTETEGVPSTA 48 + IG G +YK +K V +K RL +G Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 49 I------REISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLP 102 + +E + L K+ + + +V E + + + Sbjct: 154 LSRLAANKEYQFMSMLYSKGF-KVPEPFDNSRHI-VVMELIEGYPMRRLRKHKNIPKLYS 211 Query: 103 LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT------EGAIKLADF 146 + ++ L + ++H D N++I + + DF Sbjct: 212 DLMCFIVDLA-------NSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >2X8T-A nrPDB Length = 471 Score = 34.0 bits (77), Expect = 0.071, Method: Composition-based stats. Identities = 12/44 (27%), Positives = 21/44 (47%), Gaps = 1/44 (2%) Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLP 102 HPN+V + KL++V+ + ++ + TG PLP Sbjct: 165 KHPNVVDPHTFFDKDGKLWMVYGSYSGGIF-ILEMNPKTGFPLP 207 >6G18-v nrPDB Length = 552 Score = 34.0 bits (77), Expect = 0.081, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 30/79 (37%), Gaps = 15/79 (18%) Query: 72 TENKLYLVFEFLHQ----DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 N+ +V E ++ + D +++ + LI +H ++H D Sbjct: 180 DYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVK-----------LANHGLIHGD 228 Query: 128 LKPQNLLINTEGAIKLADF 146 NL+++ I + DF Sbjct: 229 FNEFNLILDESDHITMIDF 247 >6DFL-A nrPDB Length = 259 Score = 33.3 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 21/98 (21%), Positives = 38/98 (38%), Gaps = 4/98 (4%) Query: 74 NKLYLVFEFLHQ--DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQ 131 ++V E L DL+ F P L ++ + + + + H V HRD Sbjct: 108 QHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHRAGVNHRDCYIC 167 Query: 132 NLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYR 169 + L++T+ + DF L+ R T + +R Sbjct: 168 HFLLHTDKPVSADDFRLSVI--DLHRAQTRDATPKRWR 203 >5YK0-A nrPDB Length = 452 Score = 32.9 bits (74), Expect = 0.19, Method: Composition-based stats. Identities = 8/26 (30%), Positives = 15/26 (57%) Query: 122 RVLHRDLKPQNLLINTEGAIKLADFG 147 ++H D P N ++ +G + + DFG Sbjct: 286 GLMHGDAHPGNFMLLPDGRMGIIDFG 311 >6FDN-A nrPDB Length = 320 Score = 32.9 bits (74), Expect = 0.19, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 30/79 (37%), Gaps = 15/79 (18%) Query: 72 TENKLYLVFEFLHQ----DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127 N+ +V E ++ + D +++ + LI +H ++H D Sbjct: 180 DYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVK-----------LANHGLIHGD 228 Query: 128 LKPQNLLINTEGAIKLADF 146 NL+++ I + DF Sbjct: 229 FNEFNLILDESDHITMIDF 247 >3LV4-A nrPDB Length = 456 Score = 32.1 bits (72), Expect = 0.28, Method: Composition-based stats. Identities = 12/44 (27%), Positives = 19/44 (43%), Gaps = 1/44 (2%) Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLP 102 HPN+V KL++V+ + ++ TG PLP Sbjct: 142 KHPNVVDPHTFFDQNGKLWMVYGSYSGGIF-ILEMDKKTGFPLP 184 >4FDJ-A nrPDB Length = 502 Score = 31.7 bits (71), Expect = 0.35, Method: Composition-based stats. Identities = 22/124 (17%), Positives = 35/124 (28%), Gaps = 29/124 (23%) Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSE--------IDQLFRIFRTLGTP 222 PE+L Y S V W LG R F + F + P Sbjct: 99 PELLKKAGYVSKIVGKWHLGH--------RPQFHPLKHGFDEWFGSPNCHFGPYDNKARP 150 Query: 223 DEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 282 + V+ + Y FP + + + ++ + + A Sbjct: 151 NIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKR-------------QARH 197 Query: 283 HPFF 286 HPFF Sbjct: 198 HPFF 201 >6EF6-A nrPDB Length = 354 Score = 31.3 bits (70), Expect = 0.47, Method: Composition-based stats. Identities = 14/80 (17%), Positives = 26/80 (32%), Gaps = 18/80 (22%) Query: 81 EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH-----------RVLHRDLK 129 E D ++ G+ L + H ++H DL+ Sbjct: 178 EHCLGDTPRWGRWQDAEGVGASETAL----LTRAQDLLHRKLEEYGSGPDRYGLIHADLR 233 Query: 130 PQNLLINT---EGAIKLADF 146 NLL+++ + I + DF Sbjct: 234 LANLLVDSSTPQRTITVIDF 253 >3CNW-A nrPDB Length = 148 Score = 30.9 bits (69), Expect = 0.63, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 34/72 (47%), Gaps = 2/72 (2%) Query: 216 FRTLGTPDEV--VWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNK 273 G+P++V + G S+PD+ P P + +V + DG +++ ++ ++ + Sbjct: 10 MEIFGSPEQVWQLIGGFNSLPDWLPYIPSSKLTEGGRVRHLANPDGDTIIERLEVFNDKE 69 Query: 274 RISAKAALAHPF 285 R + + PF Sbjct: 70 RYYTYSIMNAPF 81 >5XGF-A nrPDB Length = 300 Score = 30.2 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 22/96 (22%), Positives = 32/96 (33%), Gaps = 22/96 (22%) Query: 30 VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD-------VIHTENKLY-LVFE 81 A K ++ E +EI + K N D H+ N++Y L+F Sbjct: 174 YAEKVLQNVKEDNEKDEAKRQEILIAKTFN------FYDYMLFQRLAFHSGNQIYGLIF- 226 Query: 82 FLHQDLKKFMDASALTGIPLP----LIKSYLFQLLQ 113 LKK D P L + QLL+ Sbjct: 227 ---NGLKKLYDRVGSYYFSNPASRELALKFYHQLLE 259 >3F7W-A nrPDB Length = 288 Score = 30.2 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 26/66 (39%), Gaps = 4/66 (6%) Query: 82 FLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC----HSHRVLHRDLKPQNLLINT 137 + Q + ++ +A G P + ++L L +H DL N+L Sbjct: 145 YAEQRILPYLRRAADRGALTPGDVRLVEKVLDALDHLAGDPEPPARIHGDLWNGNVLWQD 204 Query: 138 EGAIKL 143 +GA+ + Sbjct: 205 DGAVVI 210 >3IHP-A nrPDB Length = 854 Score = 29.8 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 29/95 (30%), Gaps = 8/95 (8%) Query: 196 MVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPL 255 ++ R F G + +R G P V +T S+ + + L Sbjct: 236 ILCGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTITPDGADVYSYDEDDMVLDPSLAEHL 295 Query: 256 DEDGRSLLSQ------M--LHYDPNKRISAKAALA 282 G +L M L D N+RI + Sbjct: 296 SHFGIDMLKMQKTDKTMTELEIDMNQRIGEWELIQ 330 >6BQ8-A nrPDB Length = 152 Score = 29.4 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 23/146 (15%), Positives = 48/146 (32%), Gaps = 20/146 (13%) Query: 41 TEGVPSTAIREISLLKELNHPNIVKLLDVIHT---ENKLYLVFEFLHQDLKKFMDASALT 97 + +R +SLLK L + K++D + + Y++ E F+ A Sbjct: 7 RDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTF-FILAKGKV 65 Query: 98 GIPLPLIKSYLFQLLQGL---AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV 154 + QL++ L + ++ D++ N++ L + Sbjct: 66 KVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLV---------I 116 Query: 155 PVRTYTHEVVTLWYRAPEILLGCKYY 180 T+ V T E+ + Y Sbjct: 117 DRETFNQTVGTFE----ELQKYLEGY 138 >5N1Q-B nrPDB Length = 443 Score = 29.4 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 27/81 (33%), Gaps = 6/81 (7%) Query: 62 NIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 NI LL L +V ++ K M+A A I + + Sbjct: 174 NIASLLGAPSNMEGLGYALRNIMVNHYVATTKKNLMNAVAFASIMEQTAMFEMGDAIGSF 233 Query: 116 AFCHSHRVLHRDLKPQNLLIN 136 H + ++ L NL+I+ Sbjct: 234 ERMHLLGLAYQGLNSDNLVID 254 >5N28-B nrPDB Length = 444 Score = 29.4 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 27/81 (33%), Gaps = 6/81 (7%) Query: 62 NIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115 NI LL L +V ++ K M+A A I + + Sbjct: 174 NIASLLGAPTNLEGLGYALRNIMVNHYVATTKKNIMNAVAFASIMEQTAMFEMGDAIGSF 233 Query: 116 AFCHSHRVLHRDLKPQNLLIN 136 H + ++ L NL+I+ Sbjct: 234 ERLHLLGLAYQGLNADNLVID 254 >4BVU-A nrPDB Length = 211 Score = 29.0 bits (64), Expect = 2.6, Method: Composition-based stats. Identities = 25/147 (17%), Positives = 48/147 (32%), Gaps = 23/147 (15%) Query: 6 KVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVK 65 + IG+G+ +++ N + K + + + A +E L Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALYK--KYDLIGNQYNEILEMAWQESELFN--------A 93 Query: 66 LLD-----VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120 VI +YL + +D IP + YL + + + Sbjct: 94 FYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDT---ADIPDNIESLYLQLICK----LNE 146 Query: 121 HRVLHRDLKPQNLLINTEGA-IKLADF 146 ++H DL N+L + E + DF Sbjct: 147 LSIIHYDLNTGNMLYDKESESLFPIDF 173 >5FBM-A nrPDB Length = 99 Score = 28.6 bits (63), Expect = 3.4, Method: Composition-based stats. Identities = 14/45 (31%), Positives = 21/45 (46%), Gaps = 6/45 (13%) Query: 5 QKVEKIGEGTYGVVY-----KARNKLTGEVVALKKIRLDTETEGV 44 +KV+ IG G + V K RN TGE + +K ++ G Sbjct: 41 EKVQLIGFGNF-EVRERAARKGRNPQTGEEIKIKASKVPAFKAGK 84 >5JY7-I nrPDB Length = 441 Score = 28.2 bits (62), Expect = 4.9, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 17/39 (43%), Gaps = 5/39 (12%) Query: 53 SLLKELNHPNIVKLLDVIHT--ENKLY---LVFEFLHQD 86 +L +P++ +LL T E + Y +V EF Sbjct: 162 RVLARAGNPHVARLLGSFETEWEGEPYALGMVTEFAANS 200 >2UZK-A nrPDB Length = 97 Score = 27.9 bits (61), Expect = 5.2, Method: Composition-based stats. Identities = 7/37 (18%), Positives = 16/37 (43%), Gaps = 5/37 (13%) Query: 261 SLLSQMLHYDPNKRISAKAA-----LAHPFFQDVTKP 292 L+++ + P+KR++ P+F+D Sbjct: 8 DLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDS 44 >5LJ3-H nrPDB Length = 591 Score = 27.9 bits (61), Expect = 5.3, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 16/30 (53%), Gaps = 1/30 (3%) Query: 125 HRDLKPQNLLINTEGAIK-LADFGLARAFG 153 HRDL N+LI + K + DF L + G Sbjct: 41 HRDLFQVNILIGRDIICKNVVDFTLNKQNG 70 >4D0L-A nrPDB Length = 566 Score = 27.9 bits (61), Expect = 5.8, Method: Composition-based stats. Identities = 19/113 (16%), Positives = 48/113 (42%), Gaps = 14/113 (12%) Query: 132 NLLINTEGAIKLADFG--LARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL 189 N+L++ EG I DFG L+ + + +T + +++ G D+++ Sbjct: 443 NILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFV--DVMGGLDG-----DMFNY 495 Query: 190 GCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEV-VWPGVTSMPDYKPSFP 241 +M+ + L +D++ +I + ++ + G +++ + K F Sbjct: 496 ----YKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFH 544 >6GL3-A nrPDB Length = 386 Score = 27.9 bits (61), Expect = 5.8, Method: Composition-based stats. Identities = 19/113 (16%), Positives = 48/113 (42%), Gaps = 14/113 (12%) Query: 132 NLLINTEGAIKLADFG--LARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL 189 N+L++ EG I DFG L+ + + +T + +++ G D+++ Sbjct: 264 NILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFV--DVMGGLDG-----DMFNY 316 Query: 190 GCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEV-VWPGVTSMPDYKPSFP 241 +M+ + L +D++ +I + ++ + G +++ + K F Sbjct: 317 ----YKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFH 365 >5A0Z-A nrPDB Length = 792 Score = 27.5 bits (60), Expect = 6.8, Method: Composition-based stats. Identities = 10/66 (15%), Positives = 23/66 (34%), Gaps = 2/66 (3%) Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQL-LQGLAFCHSHRVLH 125 ++ + ++ L + D D + + + L + S R +H Sbjct: 459 IEFVLNRGRMVLFDSYQGLDTGDLRDLRTFDEFDAAVKQQIAHIVRLSAIGTVISQR-VH 517 Query: 126 RDLKPQ 131 RD+ P+ Sbjct: 518 RDVAPK 523 >5C4G-E nrPDB Length = 529 Score = 27.5 bits (60), Expect = 7.6, Method: Composition-based stats. Identities = 19/113 (16%), Positives = 48/113 (42%), Gaps = 14/113 (12%) Query: 132 NLLINTEGAIKLADFG--LARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL 189 N+L++ EG I DFG L+ + + +T + +++ G D+++ Sbjct: 406 NILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFV--DVMGGLDG-----DMFNY 458 Query: 190 GCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEV-VWPGVTSMPDYKPSFP 241 +M+ + L +D++ +I + ++ + G +++ + K F Sbjct: 459 ----YKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFH 507 >6GML-W nrPDB Length = 584 Score = 27.5 bits (60), Expect = 7.9, Method: Composition-based stats. Identities = 18/63 (28%), Positives = 28/63 (44%), Gaps = 3/63 (4%) Query: 48 AIREISLLKELNHPNIVKLL-DVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLI 104 + EIS +L HP +++LL + TE+ V E L + L M G LP++ Sbjct: 448 LLDEISTCHQLLHPQVLQLLVKLFETEHSQLDVMEQLELKKTLLDRMVHLLSRGYVLPVV 507 Query: 105 KSY 107 Sbjct: 508 SYI 510 >3NPK-A nrPDB Length = 291 Score = 27.5 bits (60), Expect = 7.9, Method: Composition-based stats. Identities = 7/27 (25%), Positives = 14/27 (51%) Query: 102 PLIKSYLFQLLQGLAFCHSHRVLHRDL 128 P + + + L F H++ ++H DL Sbjct: 56 PELLNQALDVALALEFIHTYSLIHDDL 82 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.158 0.512 Lambda K H 0.267 0.0484 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,111,550 Number of Sequences: 36641 Number of extensions: 631291 Number of successful extensions: 6046 Number of sequences better than 10.0: 522 Number of HSP's better than 10.0 without gapping: 958 Number of HSP's successfully gapped in prelim test: 44 Number of HSP's that attempted gapping in prelim test: 1806 Number of HSP's gapped (non-prelim): 1213 length of query: 298 length of database: 10,336,785 effective HSP length: 96 effective length of query: 202 effective length of database: 6,819,249 effective search space: 1377488298 effective search space used: 1377488298 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 59 (27.1 bits)