BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P23965 (289 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1XX4-A nrPDB 543 e-155 5Z7R-A nrPDB 93 2e-19 2PPY-A nrPDB 92 2e-19 3H81-A nrPDB 79 2e-15 4FZW-A nrPDB 79 3e-15 5ZAI-A nrPDB 75 3e-14 5ZRV-A nrPDB 74 7e-14 5YLO-A nrPDB 73 1e-13 2D3T-A nrPDB 68 5e-12 1NZY-B nrPDB 65 4e-11 5JBW-A nrPDB 65 5e-11 5WYB-B nrPDB 64 6e-11 3MOY-A nrPDB 64 8e-11 2DUB-A nrPDB 64 8e-11 4B3J-A nrPDB 62 2e-10 2VSU-C nrPDB 62 3e-10 2HW5-A nrPDB 57 8e-09 3ZWA-A nrPDB 56 2e-08 6IUM-B nrPDB 56 2e-08 4JSB-A nrPDB 55 3e-08 2WTB-A nrPDB 55 4e-08 4J2U-A nrPDB 53 1e-07 4HDT-A nrPDB 51 5e-07 4ZU2-A nrPDB 50 9e-07 2UZF-A nrPDB 50 1e-06 2IEX-A nrPDB 48 5e-06 3HE2-A nrPDB 47 9e-06 4JCS-A nrPDB 47 1e-05 5VE2-A nrPDB 47 1e-05 3T88-A nrPDB 45 3e-05 3OME-A nrPDB 44 6e-05 3I47-A nrPDB 44 8e-05 1EF9-A nrPDB 44 9e-05 3HP0-A nrPDB 43 1e-04 4IZC-A nrPDB 40 0.001 6OJM-A nrPDB 39 0.002 4JWV-A nrPDB 39 0.003 2A81-A nrPDB 38 0.005 4EML-A nrPDB 37 0.011 3M6N-A nrPDB 35 0.033 3LAO-A nrPDB 34 0.095 4JFC-A nrPDB 33 0.18 3HIN-A nrPDB 32 0.22 4FZW-C nrPDB 32 0.44 2NP9-A nrPDB 30 1.1 5MRE-88 nrPDB 29 2.7 3TTK-A nrPDB 29 2.8 2WGW-B nrPDB 28 3.2 3RST-A nrPDB 28 5.7 4KWB-A nrPDB 28 5.8 2XFR-A nrPDB 28 6.0 6H7W-Q nrPDB 27 8.7 >1XX4-A nrPDB Length = 261 Score = 543 bits (1398), Expect = e-155, Method: Compositional matrix adjust. Identities = 261/261 (100%), Positives = 261/261 (100%) Query: 29 FSNKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERP 88 FSNKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERP Sbjct: 1 FSNKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERP 60 Query: 89 GIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTC 148 GIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTC Sbjct: 61 GIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTC 120 Query: 149 DYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVG 208 DYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVG Sbjct: 121 DYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVG 180 Query: 209 LVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFI 268 LVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFI Sbjct: 181 LVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFI 240 Query: 269 SRDSIQKSLHVYLEKLKQKKG 289 SRDSIQKSLHVYLEKLKQKKG Sbjct: 241 SRDSIQKSLHVYLEKLKQKKG 261 >5Z7R-A nrPDB Length = 267 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 67/253 (26%), Positives = 126/253 (49%), Gaps = 5/253 (1%) Query: 34 VLVEKEGEAGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFS 92 V++EKEG+ +AV+ P +N+L+ + L E + ++END + VILT F Sbjct: 6 VILEKEGK--VAVVTINRPKALNALNSDTLKEMDYVIGEIENDSEVLAVILTGAGEKSFV 63 Query: 93 AGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRI 152 AG D+ EM N ++ +++ RL L +I+A+NG + GGC +A++CD RI Sbjct: 64 AGADISEMKEMNTIEGRKFGILGNKVFRRLELLEKPVIAAVNGFALGGGCEIAMSCDIRI 123 Query: 153 MADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDE 212 + N+++ G E LGI F +G A++ + EAL++GLV++ Sbjct: 124 ASSNARF--GQPEVGLGITPGFGGTQRLSRLVGMGMAKQLIFTAQNIKADEALRIGLVNK 181 Query: 213 VVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDS 272 VV ++ + A+ + K + + +L+K + + ++ + + F S + Sbjct: 182 VVEPSELMNTAKEIANKIVSNAPVAVKLSKQAINRGMQCDIDTALAFESEAFGECFSTED 241 Query: 273 IQKSLHVYLEKLK 285 + ++ ++EK K Sbjct: 242 QKDAMTAFIEKRK 254 >2PPY-A nrPDB Length = 265 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 75/248 (30%), Positives = 114/248 (45%), Gaps = 11/248 (4%) Query: 41 EAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEM 100 E GIA + NS LEF EF +++ + D I+ VI+ S+ P FSAG D+ + Sbjct: 16 EDGIAEIHLHINKSNSYDLEFYKEFNAAIDDIRFDPDIKVVIVMSDVPKFFSAGADINFL 75 Query: 101 YGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYT 160 +P ++ E ++ S I+ + G + GG MAL CD R M D + Sbjct: 76 RSADPRFKTQFCLFCNETLDKIARSPQVYIACLEGHTVGGGLEMALACDLRFMGDEAG-K 134 Query: 161 IGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQL---GTLFPPAEALKVGLVDEVVPED 217 IGL E LG++A IG+ RAL + G P EAL++GLV+ V P+ Sbjct: 135 IGLPEVSLGVLAGTGGTQRLARLIGY---SRALDMNITGETITPQEALEIGLVNRVFPQA 191 Query: 218 QVHSKARSVMAKWFTIPDHSRQLTK--SMMRKATADNLIKQREADIQNFTSFISRDSIQK 275 + + R K ++ K M K N+ + E ++QN F S D+ ++ Sbjct: 192 ETRERTREYARKLANSATYAVSNIKLAIMNGKEMPLNVAIRYEGELQNLL-FRSEDA-KE 249 Query: 276 SLHVYLEK 283 L +LEK Sbjct: 250 GLSAFLEK 257 >3H81-A nrPDB Length = 278 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 64/261 (24%), Positives = 119/261 (45%), Gaps = 10/261 (3%) Query: 25 GARRFSNKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILT 84 G + + +LVE++ GI + + +N+L+ + + E + +L++D I +I+T Sbjct: 18 GPGSMTYETILVERDQRVGIITLN-RPQALNALNSQVMNEVTSAATELDDDPDIGAIIIT 76 Query: 85 SERPGIFSAGLDLMEMYGRN--PAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGC 142 F+AG D+ EM A A+++ W +L I+A+ G + GGC Sbjct: 77 GSAKA-FAAGADIKEMADLTFADAFTADFFAT----WGKLAAVRTPTIAAVAGYALGGGC 131 Query: 143 LMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPA 202 +A+ CD I AD +K+ G E LG++ IG A + G A Sbjct: 132 ELAMMCDVLIAADTAKF--GQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTMDAA 189 Query: 203 EALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQ 262 EA + GLV VVP D + ++AR+ + + ++ K + +A +L + + + Sbjct: 190 EAERSGLVSRVVPADDLLTEARATATTISQMSASAARMAKEAVNRAFESSLSEGLLYERR 249 Query: 263 NFTSFISRDSIQKSLHVYLEK 283 F S + + + + ++EK Sbjct: 250 LFHSAFATEDQSEGMAAFIEK 270 >4FZW-A nrPDB Length = 258 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 63/229 (27%), Positives = 103/229 (44%), Gaps = 5/229 (2%) Query: 55 NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRNPAHYAEYWKA 114 N+L+ L + V LE D SI ++T F+AG DL EM ++ A A Sbjct: 27 NALNNALLMQLVNELEAAATDTSISVCVITGN-ARFFAAGADLNEMAEKDLA--ATLNDT 83 Query: 115 VQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPF 174 +LW RL N LI+A+NG + GC +AL CD + +N+++ GL E LGI+ Sbjct: 84 RPQLWARLQAFNKPLIAAVNGYALGAGCELALLCDVVVAGENARF--GLPEITLGIMPGA 141 Query: 175 WLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVHSKARSVMAKWFTIP 234 + ++G A + + G +A + GLV +V P D A + +K Sbjct: 142 GGTQRLIRSVGKSLASKMVLSGESITAQQAQQAGLVSDVFPSDLTLEYALQLASKMARHS 201 Query: 235 DHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQKSLHVYLEK 283 + Q K +R++ L + Q FT + + + + +L+K Sbjct: 202 PLALQAAKQALRQSQEVALQAGLAQERQLFTLLAATEDRHEGISAFLQK 250 >5ZAI-A nrPDB Length = 259 Score = 75.1 bits (183), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 105/230 (45%), Gaps = 3/230 (1%) Query: 54 VNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRNPAHYAEYWK 113 +N+L+ + L E ++ + E+D IR +I+T + F AG D+ + PA ++ K Sbjct: 25 LNALNAKLLEELDRAVSQAESDPEIRVIIITG-KGKAFCAGADITQFNQLTPAEAWKFSK 83 Query: 114 AVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAP 173 +E+ ++ + I+ ING + GG +AL CD RI A+ ++ +GL E LGI Sbjct: 84 KGREIMDKIEALSKPTIAMINGYALGGGLELALACDIRIAAEEAQ--LGLPEINLGIYPG 141 Query: 174 FWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVHSKARSVMAKWFTI 233 + IG A + G P +A K GLV+ VVP + + R + K Sbjct: 142 YGGTQRLTRVIGKGRALEMMMTGDRIPGKDAEKYGLVNRVVPLANLEQETRKLAEKIAKK 201 Query: 234 PDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQKSLHVYLEK 283 S L K ++ + L+ + + S + ++ + +LEK Sbjct: 202 SPISLALIKEVVNRGLDSPLLSGLALESVGWGVVFSTEDKKEGVSAFLEK 251 >5ZRV-A nrPDB Length = 763 Score = 73.9 bits (180), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 52/174 (29%), Positives = 84/174 (48%), Gaps = 3/174 (1%) Query: 44 IAVMKFKNP--PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDL-MEM 100 +AV++ +P VN+LS E +EF + ++ IR +L S +PG F AG D+ M Sbjct: 49 VAVVRINSPNSKVNTLSKELHSEFSEVMNEIWASDQIRSAVLISSKPGCFIAGADINMLA 108 Query: 101 YGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYT 160 + + + Q + +L S +++AING+ GG +A++C YRI + K Sbjct: 109 ACKTLQEVTQLSQEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTV 168 Query: 161 IGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVV 214 +G E LLG + +G AA + G A K+GLVD++V Sbjct: 169 LGTPEVLLGALPGAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLV 222 >5YLO-A nrPDB Length = 271 Score = 72.8 bits (177), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 103/226 (45%), Gaps = 11/226 (4%) Query: 41 EAGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILT-SERPGIFSAGLDLM 98 EAGIA + P N+L + L + L+ E D ++R V+L S R F AG DL Sbjct: 12 EAGIAWLVLNRPQQRNALDIPTLEALHVRLDACERDPAVRAVVLGGSGRS--FCAGADLA 69 Query: 99 E---MYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMAD 155 E R + +A L RL+ + ++A+NG++ G +AL CD+RI A Sbjct: 70 EWAAAEARGELESYGWTEAAHALMGRLHALDKPTVAAVNGSAVGAGMDLALCCDFRIAAA 129 Query: 156 NSKYTIGLNE-SLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVV 214 ++++ G + W + +G AA+R L L + AL GLV EVV Sbjct: 130 SARFKAGYTGMAYCPDAGASW---HLPRLLGSEAAKRLLFLDEAWSAERALGAGLVGEVV 186 Query: 215 PEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREAD 260 ++ + + A+ + P + TK ++R +L +Q A+ Sbjct: 187 ADEHLVEAVGAFAARLASGPTFAFAQTKRLLRDGAGRSLAEQLRAE 232 >2D3T-A nrPDB Length = 715 Score = 67.8 bits (164), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 59/197 (29%), Positives = 94/197 (47%), Gaps = 8/197 (4%) Query: 41 EAGIAVMKF--KNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLM 98 E+GI +KF K VN + L E +++ ++ D S++GVI++S + +F G D+ Sbjct: 14 ESGIVELKFDLKGESVNKFNRLTLNELRQAVDAIKADASVKGVIVSSGKD-VFIVGADIT 72 Query: 99 EMYGRNPAHYAEYWKA---VQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMAD 155 E AE +++ N+ ++AING + GG M L D+R+MAD Sbjct: 73 EFVENFKLPDAELIAGNLEANKIFSDFEDLNVPTVAAINGIALGGGLEMCLAADFRVMAD 132 Query: 156 NSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVP 215 ++K IGL E LGI F IG A + G +ALKV VD VV Sbjct: 133 SAK--IGLPEVKLGIYPGFGGTVRLPRLIGVDNAVEWIASGKENRAEDALKVSAVDAVVT 190 Query: 216 EDQVHSKARSVMAKWFT 232 D++ + A ++ + + Sbjct: 191 ADKLGAAALDLIKRAIS 207 >1NZY-B nrPDB Length = 269 Score = 64.7 bits (156), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 64/250 (25%), Positives = 111/250 (44%), Gaps = 13/250 (5%) Query: 41 EAGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLME 99 E G+A + K P N+LS++ + E +L + E D S+ V++T F AG L E Sbjct: 10 EDGVAEITIKLPRHRNALSVKAMQEVTDALNRAEEDDSVGAVMITGAEDA-FCAGFYLRE 68 Query: 100 M-YGRNPAHYAEYWKAVQELWLRLYLSNLT-----LISAINGASPAGGCLMALTCDYRIM 153 + + A ++++ + LW + + +++AING + GG ++L D I Sbjct: 69 IPLDKGVAGVRDHFR-IAALWWHQMIHKIIRVKRPVLAAINGVAAGGGLGISLASDMAIC 127 Query: 154 ADNSKYTIGLNESLLGIVAPFWLKDNYVNTIG-HRAAERALQLGTLFPPAEALKVGLVDE 212 AD++K+ + +GI + +G RA E L TL+P EA GLV Sbjct: 128 ADSAKFVCAWH--TIGIGNDTATSYSLARIVGMRRAMELMLTDRTLYP-EEAKDWGLVSR 184 Query: 213 VVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDS 272 V P+D+ A V + P H + + K + + E +IQN + ++ Sbjct: 185 VYPKDEFREVAWKVARELAAAPTHLQVMAKERFHAGWMQPVEECTEFEIQNVIASVTHPH 244 Query: 273 IQKSLHVYLE 282 L +L+ Sbjct: 245 FMPCLTRFLD 254 >5JBW-A nrPDB Length = 260 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 44/165 (26%), Positives = 74/165 (44%), Gaps = 2/165 (1%) Query: 55 NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRNPAHYAEYWKA 114 N++S L E + ++ + + +R V++T F AG DL E + Sbjct: 26 NAISRAMLKELGELVTRVSSSRDVRAVVITGAGDKAFCAGADLKERATMAEDEVRAFLDG 85 Query: 115 VQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPF 174 ++ + + S+ I+AINGA+ GG +AL CD R+ A ++ +GL E LGI+ Sbjct: 86 LRRTFRAIEKSDCVFIAAINGAALGGGTELALACDLRVAAPAAE--LGLTEVKLGIIPGG 143 Query: 175 WLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQV 219 +G A+ + AEA VGL + + PE + Sbjct: 144 GGTQRLARLVGPGRAKDLILTARRINAAEAFSVGLANRLAPEGHL 188 >5WYB-B nrPDB Length = 280 Score = 64.3 bits (155), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 54/187 (28%), Positives = 81/187 (43%), Gaps = 14/187 (7%) Query: 33 RVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFS 92 ++ VEK G A++ +PP N+ + L +E L D I +++T + P FS Sbjct: 18 KLTVEKHGH--TALITINHPPANTWDRDSLIGLRQLIEHLNRDDDIYALVVTGQGPKFFS 75 Query: 93 AGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRI 152 AG DL + A E + E + L I+AING + GG AL CD RI Sbjct: 76 AGADLNMFADGDKARAREMARRFGEAFEALRDFRGVSIAAINGYAMGGGLECALACDIRI 135 Query: 153 MADNSKY-----TIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKV 207 ++ +GL G A WL +G A+R + AL++ Sbjct: 136 AERQAQMALPEAAVGLLPCAGGTQALPWL-------VGEGWAKRMILCNERVDAETALRI 188 Query: 208 GLVDEVV 214 GLV++VV Sbjct: 189 GLVEQVV 195 >3MOY-A nrPDB Length = 263 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 51/187 (27%), Positives = 85/187 (45%), Gaps = 8/187 (4%) Query: 42 AGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILT-SERPGIFSAGLDLME 99 AG+ +++ P +N+L+ E + + + D I +++T SER F+AG D+ E Sbjct: 18 AGVGLIRLDRPDALNALNQTLEAEVLDAARDFDADLEIGAIVVTGSER--AFAAGADIAE 75 Query: 100 MYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKY 159 M P E + + W L +++A+ G + GGC +A+ CD I AD +++ Sbjct: 76 MVTLTPHQARE--RNLLSGWDSLTQVRKPIVAAVAGYALGGGCELAMLCDLVIAADTARF 133 Query: 160 TIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQV 219 G E LGI+ +G A G EA +VGLV +VP + Sbjct: 134 --GQPEITLGILPGLGGTQRLTRAVGKAKAMDLCLTGRSLTAEEAERVGLVSRIVPAADL 191 Query: 220 HSKARSV 226 +A +V Sbjct: 192 LDEALAV 198 >2DUB-A nrPDB Length = 261 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 60/257 (23%), Positives = 113/257 (43%), Gaps = 13/257 (5%) Query: 34 VLVEKEGE-AGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIF 91 ++ EK+G+ + + +++ P +N+L + E +LE E D ++ ++LT F Sbjct: 7 IITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAVGAIVLTGGEKA-F 65 Query: 92 SAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYR 151 +AG D+ EM +N Y W + +I+A+NG + GGC +A+ CD Sbjct: 66 AAGADIKEM--QNRTFQDCYSGKFLSHWDHITRIKKPVIAAVNGYALGGGCELAMMCD-- 121 Query: 152 IMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVD 211 I+ K G E LLG + +G A + G +A + GLV Sbjct: 122 IIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVS 181 Query: 212 EVVPEDQVHSKARSVMAKWFTIPDHSR---QLTKSMMRKATADNLIKQREADIQNFTSFI 268 ++ P + + +A K I ++S+ + K + A L + + + + F S Sbjct: 182 KIFPVETLVEEAIQCAEK---IANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTF 238 Query: 269 SRDSIQKSLHVYLEKLK 285 + D ++ + ++EK K Sbjct: 239 ATDDRREGMSAFVEKRK 255 >4B3J-A nrPDB Length = 736 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/179 (30%), Positives = 89/179 (49%), Gaps = 8/179 (4%) Query: 43 GIAVMKFKNPP--VNSLSLEFLTEFVISLEKLENDK-SIRGVILTSERPGIFSAGLDLME 99 GI + +P N ++ ++ ++++L +K SI GV++ S + F+ G D+ Sbjct: 30 GIVTLTMDDPSGSTNVMNEAYIESMGKAVDRLVAEKDSITGVVVASAKKTFFAGG-DVKT 88 Query: 100 MYGRNPAHYAEYWKAVQELWLRL-YLSNL--TLISAINGASPAGGCLMALTCDYRIMADN 156 M P + + V+ + +L L L +++AINGA+ GG +AL C +RI AD Sbjct: 89 MIQARPEDAGDVFNTVETIKRQLRTLETLGKPVVAAINGAALGGGLEIALACHHRIAADV 148 Query: 157 SKYTIGLNESLLGIVAPFWLKDNYVNTIG-HRAAERALQLGTLFPPAEALKVGLVDEVV 214 +GL E LG++ V G A L GT F PA+A ++GLVDE+V Sbjct: 149 KGSQLGLPEVTLGLLPGGGGVTRTVRMFGIQNAFVSVLAQGTRFKPAKAKEIGLVDELV 207 >2VSU-C nrPDB Length = 275 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 58/191 (30%), Positives = 88/191 (46%), Gaps = 9/191 (4%) Query: 36 VEKEGEAGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAG 94 V+ E E GIA + P N++S E + LE LE D + GV++ + ++AG Sbjct: 11 VKVEIEDGIAFVILNRPEKRNAMSPTLNREMIDVLETLEQDPAA-GVLVLTGAGEAWTAG 69 Query: 95 LDLMEMYGR---NPAHYAEYWK--AVQELWLRLYLSNLTLISAINGASPAGGCLMALTCD 149 +DL E + P E + A Q W L + I+ +NG GG + CD Sbjct: 70 MDLKEYFREVDAGPEILQEKIRREASQWQWKLLRMYAKPTIAMVNGWCFGGGFAPLVACD 129 Query: 150 YRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGL 209 I AD + T GL+E GI + +T+GHR + + G F +A ++GL Sbjct: 130 LAICADEA--TFGLSEINWGIPPGNLVSKAMADTVGHRQSLYYIMTGKTFGGQKAAEMGL 187 Query: 210 VDEVVPEDQVH 220 V+E VP Q+ Sbjct: 188 VNESVPLAQLR 198 >2HW5-A nrPDB Length = 286 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 56/254 (22%), Positives = 108/254 (42%), Gaps = 7/254 (2%) Query: 34 VLVEKEGEAG-IAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIF 91 ++ EK G+ + +++ P +N+L + E +L+ E D ++ ++LT F Sbjct: 32 IIAEKRGKNNTVGLIQLNRPKALNALCDGLIDELNQALKIFEEDPAVGAIVLTGGDKA-F 90 Query: 92 SAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYR 151 +AG D+ EM +N + Y + W L +I+A+NG + GGC +A+ CD Sbjct: 91 AAGADIKEM--QNLSFQDCYSSKFLKHWDHLTQVKKPVIAAVNGYAFGGGCELAMMCD-- 146 Query: 152 IMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVD 211 I+ K E L+G + +G A + G +A + GLV Sbjct: 147 IIYAGEKAQFAQPEILIGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVS 206 Query: 212 EVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRD 271 ++ P + + +A K + + K + A L + + + + F S + D Sbjct: 207 KICPVETLVEEAIQCAEKIASNSKIVVAMAKESVNAAFEMTLTEGSKLEKKLFYSTFATD 266 Query: 272 SIQKSLHVYLEKLK 285 ++ + ++EK K Sbjct: 267 DRKEGMTAFVEKRK 280 >3ZWA-A nrPDB Length = 742 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 50/176 (28%), Positives = 82/176 (46%), Gaps = 9/176 (5%) Query: 44 IAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGR 103 +A+++ NPPVN++S + E L+K +D +++ +++ G F AG D+ Sbjct: 31 LAMIRLCNPPVNAVSPTVIREVRNGLQKAGSDHTVKAIVICGAN-GNFCAGADIHGFSAF 89 Query: 104 NPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTIGL 163 P A+ L + +++AI G + GG +AL C YRI N+K +GL Sbjct: 90 TPG------LALGSLVDEIQRYQKPVLAAIQGVALGGGLELALGCHYRIA--NAKARVGL 141 Query: 164 NESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQV 219 E LGI+ +G A + G EAL++G++D VV D V Sbjct: 142 PEVTLGILPGARGTQLLPRVVGVPVALDLITSGKYLSADEALRLGILDAVVKSDPV 197 >6IUM-B nrPDB Length = 701 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 49/180 (27%), Positives = 80/180 (44%), Gaps = 17/180 (9%) Query: 43 GIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYG 102 G+AV+ NPPVN L V + + +D +++ +++T FS G D+ E Sbjct: 10 GVAVITLDNPPVNGLGHSTRLGIVEGMTRALDDAAVKAIVITGAGKA-FSGGADIREF-- 66 Query: 103 RNPAHYAEYWKAVQELWLR-----LYLSNLTLISAINGASPAGGCLMALTCDYRIMADNS 157 P KA+QE L L S+ +++A++ + GG +AL C+YR+ + + Sbjct: 67 NTP-------KAMQEPTLHSVIRVLEGSSKPVVAAVHSVAMGGGLELALGCNYRVASKGA 119 Query: 158 KYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPED 217 + I L E LG++ IG AA + GT + L DE+V D Sbjct: 120 Q--IALPEVKLGLLPGAGGTQRLPRVIGLEAAANMIVSGTPVLSEKFAGTKLFDEIVDGD 177 >4JSB-A nrPDB Length = 296 Score = 55.1 bits (131), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 101/199 (50%), Gaps = 22/199 (11%) Query: 76 KSIRGVILTSERPGIFSAGLDL--------------MEMYGRNPAHYAEYWKAV---QEL 118 +++R V++T E P FS+G+DL + R+P A + + QE Sbjct: 77 QAVRIVVITGEGP-TFSSGIDLDMFQAGKVDGEPTPFTLLARDPNSTAALDQVIASYQEG 135 Query: 119 WLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKD 178 +L L +++ I+A+ G + G +AL+CD RI++D ++ + + E LG+V Sbjct: 136 FLWLRRADIVSIAAVRGHAIGAGFQLALSCDIRILSDTAQ--LCMKEPALGLVPDLTGTQ 193 Query: 179 NYVNTIG-HRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHS 237 V +G +RA E L T+ AEA ++ L + VV + ++ + +++A+ +P + Sbjct: 194 PLVELVGVNRAIELCLTARTI-DAAEAAQLRLAERVVADAELDAAVDALVAQLLAVPAAA 252 Query: 238 RQLTKSMMRKATADNLIKQ 256 + TK ++ +A ++L Q Sbjct: 253 ARATKELLLQAGRNDLATQ 271 >2WTB-A nrPDB Length = 725 Score = 54.7 bits (130), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 51/188 (27%), Positives = 87/188 (46%), Gaps = 6/188 (3%) Query: 40 GEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLM- 98 G G+AV+ NPPVNSLS + L + E+ + ++ +++T + G FS G D+ Sbjct: 14 GGDGVAVITLINPPVNSLSFDVLYNLKSNYEEALSRNDVKAIVITGAK-GRFSGGFDISG 72 Query: 99 --EMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADN 156 EM N + ++ + L + ++AI+G + GG +A+ C RI A Sbjct: 73 FGEMQKGNVKEPKAGYISIDIITDLLEAARKPSVAAIDGLALGGGLELAMACHARISAPA 132 Query: 157 SKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPE 216 ++ +GL E LG++ F +G A + E +GL+D VVP Sbjct: 133 AQ--LGLPELQLGVIPGFGGTQRLPRLVGLTKALEMILTSKPVKAEEGHSLGLIDAVVPP 190 Query: 217 DQVHSKAR 224 ++ + AR Sbjct: 191 AELVTTAR 198 >4J2U-A nrPDB Length = 365 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 48/212 (22%), Positives = 87/212 (41%), Gaps = 8/212 (3%) Query: 30 SNKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPG 89 S VL+ K AG + + +N+L+ + E +L D + V++ +E P Sbjct: 22 SMSDVLIRKVRRAGRITLS-RPAALNALTCAMVQEIDAALRGWIGDPEVELVVIDAEGPR 80 Query: 90 IFSAGLDLMEMYGR----NPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMA 145 F AG D+ E++GR + A ++W+ + R+ ++S + G + GG + Sbjct: 81 AFCAGGDIAELHGRGVAGDHAFGQDFWRVEYRMNDRIAAFPKPIVSLMQGFTMGGGVGLG 140 Query: 146 LTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEAL 205 +RI+ + S+ I + E +G+V G L G P +A+ Sbjct: 141 CHARHRIVGETSQ--ISMPECAIGLVPDVGGTHLLARAPGRIGVWLGLT-GARMGPGDAI 197 Query: 206 KVGLVDEVVPEDQVHSKARSVMAKWFTIPDHS 237 G D VPE ++ +PDH+ Sbjct: 198 FAGFADRFVPEADWPDLIAALEGGDLALPDHA 229 >4HDT-A nrPDB Length = 353 Score = 51.2 bits (121), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 91/209 (43%), Gaps = 23/209 (11%) Query: 31 NKRVLVEKEGEAGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPG 89 N+ VLV EG G+ ++ P +NSL+ +T L END S+R V+LT Sbjct: 8 NEDVLVNVEG--GVGLLTLNRPKAINSLTHGMVTTMAERLAAWENDDSVRAVLLTGAGER 65 Query: 90 IFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTL-------ISAINGASPAGGC 142 AG D++ +Y A AE + W Y N + +S ++G GG Sbjct: 66 GLCAGGDVVAIYHSAKADGAE----ARRFWFDEYRLNAHIGRYPKPYVSIMDGIVMGGGV 121 Query: 143 LMALTCDYRIMADNSKYTIGLNESLLGI---VAPFWLKDNYVNTIGHRAAERALQLGTLF 199 + + R++ D +K + + E +G V +L +G AA G F Sbjct: 122 GVGAHGNVRVVTDTTK--MAMPEVGIGFIPDVGGTYLLSRAPGKLGLHAA----LTGAPF 175 Query: 200 PPAEALKVGLVDEVVPEDQVHSKARSVMA 228 A+A+ +G D VP D++ R+V+A Sbjct: 176 SGADAIVMGFADHYVPHDKIDEFTRAVIA 204 >4ZU2-A nrPDB Length = 272 Score = 50.4 bits (119), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 48/159 (30%), Positives = 74/159 (46%), Gaps = 7/159 (4%) Query: 55 NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRNPAHYAEYW-- 112 N++SL + E L + +D+S+R ++L G F AG D+ +M G A Y Sbjct: 29 NAMSLAMVGELRAVLAAVRDDRSVRALVLRGA-DGHFCAGGDIKDMAGARAAGAEAYRTL 87 Query: 113 -KAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIV 171 +A L + L++ + GA GG +A D I A ++++ GL E+ LGI+ Sbjct: 88 NRAFGSLLEEAQAAPQLLVALVEGAVLGGGFGLACVSDVAIAAADAQF--GLPETSLGIL 145 Query: 172 APFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLV 210 P + V IG A R F EAL++GLV Sbjct: 146 -PAQIAPFVVRRIGLTQARRLALTAARFDGREALRLGLV 183 >2UZF-A nrPDB Length = 273 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 44/185 (23%), Positives = 83/185 (44%), Gaps = 10/185 (5%) Query: 43 GIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMY 101 GIA + P V N+ + + + E + + + +D+++ ++LT E F +G D + Sbjct: 22 GIAKVTINRPEVRNAFTPKTVAEMIDAFSRARDDQNVSVIVLTGEGDLAFCSGGDQKK-- 79 Query: 102 GRNPAHYAEYWKA----VQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNS 157 R Y + V +L + + +I+ + G + GG ++ + CD I ADN+ Sbjct: 80 -RGHGGYVGEDQIPRLNVLDLQRLIRIIPKPVIAMVKGYAVGGGNVLNVVCDLTIAADNA 138 Query: 158 KYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPED 217 + G +G + +GH+ A L + EAL +GLV+ VVP + Sbjct: 139 IF--GQTGPKVGSFDAGYGSGYLARIVGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLE 196 Query: 218 QVHSK 222 +V + Sbjct: 197 KVEDE 201 >2IEX-A nrPDB Length = 272 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 47/190 (24%), Positives = 83/190 (43%), Gaps = 8/190 (4%) Query: 43 GIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDL-MEM 100 GIA + P V N+ + + E + + K +D +I +ILT F +G D + Sbjct: 21 GIAKITINRPEVHNAFRPKTVNEMIDAFTKARDDSNIGVIILTGAGGKAFCSGGDQKVRG 80 Query: 101 YGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYT 160 +G V +L + + +I+ + G + GG ++ + CD I ADN+ + Sbjct: 81 HGGYVGEDEIPRLNVLDLQRLIRVIPKPVIAMVAGYAIGGGHVLHVVCDLTIAADNAIF- 139 Query: 161 IGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVH 220 G +G + +GH+ A L + EAL++GLV++VVP +Q+ Sbjct: 140 -GQTGPKVGSFDGGYGAGYLARIVGHKKAREIWYLCRQYTAQEALEMGLVNKVVPLEQLE 198 Query: 221 SKARSVMAKW 230 + KW Sbjct: 199 EET----VKW 204 >3HE2-A nrPDB Length = 264 Score = 47.0 bits (110), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 44/160 (27%), Positives = 74/160 (46%), Gaps = 11/160 (6%) Query: 55 NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRNPAHYAEYWKA 114 N+L+ + + E ++ K D S R ++LT + F AG DL A A+Y Sbjct: 43 NALNSQLVEELTQAIRK-AGDGSARAIVLTGQGTA-FCAGADL-----SGDAFAADYPDR 95 Query: 115 VQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPF 174 + EL + S + ++ AING + G +A+ CD R++A ++ + S G+ Sbjct: 96 LIELHKAMDASPMPVVGAINGPAIGAGLQLAMQCDLRVVAPDAFFQ--FPTSKYGLALDN 153 Query: 175 WLKDNYVNTIGHRAAERALQLGTLFPPAE-ALKVGLVDEV 213 W + +GH A RA+ L AE AL G+ + + Sbjct: 154 WSIRRLSSLVGHGRA-RAMLLSAEKLTAEIALHTGMANRI 192 >4JCS-A nrPDB Length = 286 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 47/195 (24%), Positives = 85/195 (43%), Gaps = 8/195 (4%) Query: 55 NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRNPAHYAEYWKA 114 N E + + LE++ +D IR ++LTS PG F AG +L + N YW+ Sbjct: 46 NPFDAELRADLMTVLERVRDDADIRVLVLTSH-PGSFCAGGNL-HVLRDNLDSGPAYWQQ 103 Query: 115 VQELWLRLYLSNLTL----ISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGI 170 + LR L L I+A++G + G ++LT D + + +++++ LG+ Sbjct: 104 RIKTGLRFIHDMLNLGRPVIAAVDGPAFGAGFALSLTADIVLASPRARFSMAYLR--LGL 161 Query: 171 VAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVHSKARSVMAKW 230 V +G + A+ + EA ++GLV EV + + +AR + Sbjct: 162 VPDLGALYLLPRAVGLQRAKELMFSTRELDAEEAHRLGLVMEVHESEALEQRAREIAESL 221 Query: 231 FTIPDHSRQLTKSMM 245 + LTK+ + Sbjct: 222 VQAAPTALALTKAAL 236 >5VE2-A nrPDB Length = 275 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/241 (21%), Positives = 104/241 (43%), Gaps = 30/241 (12%) Query: 55 NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRNPAHYA----- 109 N+L+ E LE+ +D IR V+LT+ F+AG DL + NP + Sbjct: 47 NALNRELYAALADELERSNHDDQIRAVLLTA-NGDTFTAGNDLDDFI--NPVEESGTPSV 103 Query: 110 -EYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYT-----IGL 163 + KA+ E ++ A+NG + G M L CD + ++++ +GL Sbjct: 104 IRFLKAISE-------CETPIVVAVNGPAIGVGLTMLLHCDMVYASKSARFRAPFTHVGL 156 Query: 164 -NESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVHSK 222 E+ ++ P + + N + + G + EAL GLV V +D + ++ Sbjct: 157 VPEAASSLLLPLAVGQAWANDL--------MLAGRILDAREALSAGLVTRVFEDDVLVAE 208 Query: 223 ARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQKSLHVYLE 282 + + + ++ +S + +K ++R + + Q + + F ++ ++S+ + E Sbjct: 209 SLKIAEQVASLAPNSVKQSKRLIRGVNKEEVQAQMKREGVIFAEQLASAEFKESVAAFFE 268 Query: 283 K 283 K Sbjct: 269 K 269 >3T88-A nrPDB Length = 289 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 43/176 (24%), Positives = 72/176 (40%), Gaps = 5/176 (2%) Query: 43 GIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLD--LME 99 GIA + P V N+ + E + +L D +I +ILT F +G D + Sbjct: 37 GIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDKAFCSGGDQKVRG 96 Query: 100 MYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKY 159 YG + V + ++ +++ + G S GG ++ + CD I ADN+ + Sbjct: 97 DYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTIAADNAIF 156 Query: 160 TIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVP 215 G +G W +G + A L + +AL +GLV+ VVP Sbjct: 157 --GQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVP 210 >3OME-A nrPDB Length = 282 Score = 44.3 bits (103), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 47/207 (22%), Positives = 87/207 (42%), Gaps = 31/207 (14%) Query: 44 IAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDL----- 97 IA + P N+ + E L E + + D ++ +IL + FSAG DL Sbjct: 33 IATITLNRPEAANAQNPELLDELDAAWTRAAEDNEVKVIILRANGKH-FSAGHDLRGGGE 91 Query: 98 ----------MEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALT 147 ++ R Y W+ V + I+A+ G +GG L+ Sbjct: 92 VPEKISLEFIIQHEARRYLDYTLRWRNVPK----------PSIAAVQGRCISGGLLLCWP 141 Query: 148 CDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKV 207 CD + +D++ ++ + +L+GI + + +G R A+ L G EA + Sbjct: 142 CDLILASDDALFSDPV--ALMGIGGVEYHGHTW--ELGPRKAKEILFTGRALTAEEAERT 197 Query: 208 GLVDEVVPEDQVHSKARSVMAKWFTIP 234 G+V+ VV D++ ++ R + + T+P Sbjct: 198 GMVNRVVARDELDAQTRELAEQIATMP 224 >3I47-A nrPDB Length = 268 Score = 43.9 bits (102), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 50/172 (29%), Positives = 80/172 (46%), Gaps = 19/172 (11%) Query: 55 NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRNPAHYAEYWKA 114 N+ + LTE I L+ ND ++R ++L + FSAG DL M ++ A++ E Sbjct: 26 NAFDNQLLTEMRIRLDSAINDTNVRVIVLKANGKH-FSAGADLTWM--QSMANFTEE--- 79 Query: 115 VQELWLRLYLSNLTL---------ISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNE 165 + L L L NL I+ + GA+ GG +A CD I + ++++ +E Sbjct: 80 -ENLEDSLVLGNLMYSISQSPKPTIAMVQGAAFGGGAGLAAACDIAIASTSARFC--FSE 136 Query: 166 SLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPED 217 LG++ P + V IG RAA+ +F A + LV VP+D Sbjct: 137 VKLGLI-PAVISPYVVRAIGERAAKMLFMSAEVFDATRAYSLNLVQHCVPDD 187 >1EF9-A nrPDB Length = 261 Score = 43.5 bits (101), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 46/169 (27%), Positives = 81/169 (47%), Gaps = 18/169 (10%) Query: 44 IAVMKFK-NPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPG-IFSAGLDLMEMY 101 +AV++F +N+LS F+ + + +L L N IR +IL + +FSAG D+ E+ Sbjct: 14 VAVIEFNYGRKLNALSKVFIDDLMQALSDL-NRPEIRCIILRAPSGSKVFSAGHDIHELP 72 Query: 102 --GRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKY 159 GR+P Y + + + + + +IS + G+ G M ++ D I A S + Sbjct: 73 SGGRDPLSYDDPLRQITRMIQKF---PKPIISMVEGSVWGGAFEMIMSSDLIIAASTSTF 129 Query: 160 T-----IGLNESLLGIV-----APFWLKDNYVNTIGHRAAERALQLGTL 198 + +G+ +L+GI A F + + T A+RAL +G L Sbjct: 130 SMTPVNLGVPYNLVGIHNLTRDAGFHIVKELIFTASPITAQRALAVGIL 178 >3HP0-A nrPDB Length = 267 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 46/188 (24%), Positives = 75/188 (39%), Gaps = 20/188 (10%) Query: 41 EAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEM 100 +A + + F P N+ + L E + + + + S V++ P +F G D E+ Sbjct: 14 QASVCYITFHRPEANNTINDTLIEECLQVLN-QCETSTVTVVVLEGLPEVFCFGADFQEI 72 Query: 101 Y-----GRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMAD 155 Y GR A E + +LW++L IS + G AGG D I Sbjct: 73 YQEMKRGRKQASSQE---PLYDLWMKLQTGPYVTISHVRGKVNAGGLGFVSATDIAIADQ 129 Query: 156 NSKYTIGLNESLLGI----VAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVD 211 + ++ L+E L G+ V PF ++ IG + A + EA + GL+D Sbjct: 130 TASFS--LSELLFGLYPACVLPFLIR-----RIGRQKAHYMTLMTKPISVQEASEWGLID 182 Query: 212 EVVPEDQV 219 E V Sbjct: 183 AFDAESDV 190 >4IZC-A nrPDB Length = 275 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 49/193 (25%), Positives = 79/193 (40%), Gaps = 14/193 (7%) Query: 43 GIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMY 101 G+ V+ P N+L + + E V + + K +R V+LT F AGLDL+E + Sbjct: 20 GVCVVTLNRPDKRNALDVATIEELV-TFFSTAHRKGVRAVVLTGAGDH-FCAGLDLVEHW 77 Query: 102 GRNPA-----HYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADN 156 + + H W E + ++ + +I+A+ GA GG +A R+M D Sbjct: 78 KADRSADDFMHVCLRW---HEAFNKMEYGGVPIIAALRGAVVGGGLALASAAHLRVM-DQ 133 Query: 157 SKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPE 216 S Y L E GI + IG + G ++ EA +GL + + E Sbjct: 134 STY-FALPEGQRGIFTGGGATIRVSDMIGKYRMIDMILTGRVYQGQEAADLGLA-QYITE 191 Query: 217 DQVHSKARSVMAK 229 KA + K Sbjct: 192 GSSFDKAMELADK 204 >6OJM-A nrPDB Length = 286 Score = 38.9 bits (89), Expect = 0.002, Method: Compositional matrix adjust. Identities = 62/271 (22%), Positives = 105/271 (38%), Gaps = 42/271 (15%) Query: 43 GIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPG------IFSAGL 95 G+A + F P + N+ + +E + D SI V+L+ E P F +G Sbjct: 28 GVARIAFNRPEIRNAFRPKTTSELYDAFYDAYEDPSIGVVLLSGEGPSPKDGGWAFCSGG 87 Query: 96 DL-----MEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDY 150 D G + H + E+ + +I+ + G + GG + + CD Sbjct: 88 DQKARGHQGYVGEDGRHRLN----ILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHVVCDL 143 Query: 151 RIMADNS---KYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKV 207 + + K T S G +L +G + A LG + EA ++ Sbjct: 144 TLASKEHAIFKQTDADVTSFDGGYGSAYL----AKMVGQKKAREIFFLGRNYSAQEAFEM 199 Query: 208 GLVDEVVP----EDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQN 263 G+V++VVP ED + A+ ++AK P R L +M T D ++ Q Q Sbjct: 200 GMVNKVVPHAELEDTAYEWAQEILAK---SPTSIRMLKFAM--NLTDDGMVGQ-----QV 249 Query: 264 FTSFISR-----DSIQKSLHVYLEKLKQKKG 289 F +R D ++ + +LEK K G Sbjct: 250 FAGEATRLAYMTDEAKEGRNAFLEKRKPDFG 280 >4JWV-A nrPDB Length = 278 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 24/87 (27%), Positives = 44/87 (50%), Gaps = 2/87 (2%) Query: 129 LISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRA 188 +++A+ G GG +A+ D + AD +++ GL E+ +GI+ + + + + Sbjct: 118 MVAAVQGFCVGGGFELAMCADIIVAADTAQF--GLPETKVGIIGECGVVHRAMRQLPYHI 175 Query: 189 AERALQLGTLFPPAEALKVGLVDEVVP 215 A + + G EA GLV+EVVP Sbjct: 176 ALQLILTGERIKADEARHYGLVNEVVP 202 >2A81-A nrPDB Length = 250 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 33/129 (25%), Positives = 57/129 (44%), Gaps = 2/129 (1%) Query: 35 LVEKEGEAGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSA 93 +V +E + V+ +P N S T +L + D S+R V++ FSA Sbjct: 1 MVFEENSDEVRVITLDHPNKHNPFSRTLETSVKDALARANADDSVRAVVVYGGAERSFSA 60 Query: 94 GLDLMEMYGRNPAHYAEYW-KAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRI 152 G D E+ + + E W V +L+ + N I+A++G + G AL D R+ Sbjct: 61 GGDFNEVKQLSRSEDIEEWIDRVIDLYQAVLNVNKPTIAAVDGYAIGMGFQFALMFDQRL 120 Query: 153 MADNSKYTI 161 MA + + + Sbjct: 121 MASTANFVM 129 >4EML-A nrPDB Length = 275 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 26/106 (24%), Positives = 50/106 (47%), Gaps = 6/106 (5%) Query: 128 TLISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHR 187 +I+ + G + GG ++ L CD I ADN+ + G +G + +G + Sbjct: 111 VVIALVAGYAIGGGHVLHLVCDLTIAADNAIF--GQTGPKVGSFDGGFGSSYLARIVGQK 168 Query: 188 AAERALQLGTLFPPAEALKVGLVDEVVPEDQVHSK----ARSVMAK 229 A L + EA ++G+V+ VVP D++ + A+ +++K Sbjct: 169 KAREIWYLCRQYSAQEAERMGMVNTVVPVDRLEEEGIQWAKEILSK 214 >3M6N-A nrPDB Length = 305 Score = 35.0 bits (79), Expect = 0.033, Method: Compositional matrix adjust. Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 2/89 (2%) Query: 130 ISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAA 189 I+ + G + GG AL+C + I+A+ +GL E L + I A Sbjct: 144 IALVQGNALGGGFEAALSC-HTIIAEEG-VMMGLPEVLFDLFPGMGAYSFMCQRISAHLA 201 Query: 190 ERALQLGTLFPPAEALKVGLVDEVVPEDQ 218 ++ + G L+ + L +GLVD VVP Q Sbjct: 202 QKIMLEGNLYSAEQLLGMGLVDRVVPRGQ 230 >3LAO-A nrPDB Length = 258 Score = 33.9 bits (76), Expect = 0.095, Method: Compositional matrix adjust. Identities = 41/167 (24%), Positives = 66/167 (39%), Gaps = 16/167 (9%) Query: 55 NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYG-------RNPAH 107 N+ L + +++ + E + R +L + F+AGLDLME+ R P Sbjct: 34 NAFDSAMLADLALAMGEYERSEESRCAVLFAHGEH-FTAGLDLMELAPKLAASGFRYPDG 92 Query: 108 YAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESL 167 + W VQ + L+ A+ G G + L D + A +++ E L Sbjct: 93 GVDPWGVVQP------RRSKPLVVAVQGTCWTAGIELMLNADIAVAARGTRFA--HLEVL 144 Query: 168 LGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVV 214 GI + G A R + G F EAL++ L+ EVV Sbjct: 145 RGIPPLGGSTVRFPRAAGWTDAMRYILTGDEFDADEALRMRLLTEVV 191 >4JFC-A nrPDB Length = 281 Score = 32.7 bits (73), Expect = 0.18, Method: Compositional matrix adjust. Identities = 52/255 (20%), Positives = 107/255 (41%), Gaps = 13/255 (5%) Query: 36 VEKEGEAGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAG 94 ++ E ++ NP N+L E + +L EN+ IR V++T E +F AG Sbjct: 27 IKSTSEGQTLILTLSNPEFRNALGPEIYAAGIEALNAAENNPEIRSVVITGEG-AVFCAG 85 Query: 95 LDLMEMYGRN---PAHYAEYWKAVQELWL---RLYLSNLTLISAINGASPAGGCLMALTC 148 +L + P A+ + + W+ R Y +I+A+ GA+ G +AL C Sbjct: 86 GNLQRLQANRREAPEVQAQSIEGLHN-WIDSIRTYPK--PVIAAVEGAAAGAGFSLALAC 142 Query: 149 DYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVG 208 D+ + A N+ + ++ S +G+ + ++ A L G +G Sbjct: 143 DFVVAASNAVFV--MSYSTVGLSPDGGGSWSLARSLPRALASELLMGGERISAQRLHDLG 200 Query: 209 LVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFI 268 LV++V S+A + + ++ K ++ +A+++ L +Q + +F + Sbjct: 201 LVNKVASAGDALSEALRMAGQLNARAPNALASIKELINEASSNTLSQQLACERDHFVRNL 260 Query: 269 SRDSIQKSLHVYLEK 283 + + + +L K Sbjct: 261 HHSNGGEGIAAFLGK 275 >3HIN-A nrPDB Length = 275 Score = 32.3 bits (72), Expect = 0.22, Method: Compositional matrix adjust. Identities = 18/71 (25%), Positives = 35/71 (49%) Query: 91 FSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDY 150 FSAGLDL E+ R+ + + ++ ++ + +I+A+ GA GG +A Sbjct: 71 FSAGLDLSELRERDATEGLVHSQTWHRVFDKIQYCRVPVIAALKGAVIGGGLELACAAHI 130 Query: 151 RIMADNSKYTI 161 R+ ++ Y + Sbjct: 131 RVAEASAYYAL 141 >4FZW-C nrPDB Length = 274 Score = 31.6 bits (70), Expect = 0.44, Method: Compositional matrix adjust. Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 2/58 (3%) Query: 41 EAGIAVMKFKNPP-VNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDL 97 E G+ + P +NS + E + L+++E D +IR ++LT G F AG DL Sbjct: 22 EKGVMTLTLNRPERLNSFNDEMHAQLAECLKQVERDDTIRCLLLTGAGRG-FCAGQDL 78 >2NP9-A nrPDB Length = 440 Score = 30.0 bits (66), Expect = 1.1, Method: Compositional matrix adjust. Identities = 51/215 (23%), Positives = 84/215 (39%), Gaps = 48/215 (22%) Query: 10 LLQAGSRLGR-RGAVDGARRFSNKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVIS 68 LL G R+G RG V R+ KRV AGI + ++ L +F++ Sbjct: 207 LLDPGVRVGLLRGGVMSHPRYRGKRVF-----SAGINLKYLSQGGIS------LVDFLMR 255 Query: 69 LEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRNPAHYAEYWKA--VQELWLRLYLSN 126 E K +RGV+ +RPG +W + +++ W Sbjct: 256 RELGYIHKLVRGVLTNDDRPG---------------------WWHSPRIEKPW------- 287 Query: 127 LTLISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGH 186 ++A++G + GG + L D R++A + Y L + GI+ P G Sbjct: 288 ---VAAVDGFAIGGGAQLLLVFD-RVLASSDAY-FSLPAAKEGII-PGAANLRLGRFAGP 341 Query: 187 RAAERALQLGTLFPPAEALKVGLVDEVVPEDQVHS 221 R + + + G E LVDEVV D++ + Sbjct: 342 RVSRQVILEGRRIWAKEPEARLLVDEVVEPDELDA 376 >5MRE-88 nrPDB Length = 457 Score = 28.9 bits (63), Expect = 2.7, Method: Compositional matrix adjust. Identities = 23/113 (20%), Positives = 53/113 (46%), Gaps = 5/113 (4%) Query: 54 VNSLSLEFLTEFVISLEKLENDKSIRGVIL-TSERPGIFSAGLDLMEM----YGRNPAHY 108 +N+L+ E +L + + VIL +S RP F AG D+ + + + A Sbjct: 23 LNALNAEMSESMFKTLNEYAKSDTTNLVILKSSNRPRSFCAGGDVATVAIFNFNKEFAKS 82 Query: 109 AEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTI 161 +++ L ++ +++ ++G + GG +++ +RI +N+K+ + Sbjct: 83 IKFFTDEYSLNFQIATYLKPIVTFMDGITMGGGVGLSIHTPFRIATENTKWAM 135 >3TTK-A nrPDB Length = 345 Score = 28.9 bits (63), Expect = 2.8, Method: Compositional matrix adjust. Identities = 16/51 (31%), Positives = 22/51 (43%) Query: 199 FPPAEALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKAT 249 FP A LV E + D + VM K +T PD + ++M R T Sbjct: 291 FPNGNAAATPLVSEAIRNDPGIYPSEEVMKKLYTFPDLPAKTQRAMTRSWT 341 >2WGW-B nrPDB Length = 248 Score = 28.5 bits (62), Expect = 3.2, Method: Compositional matrix adjust. Identities = 29/109 (26%), Positives = 49/109 (44%), Gaps = 6/109 (5%) Query: 120 LRLYLSNLTLISAIN-GASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKD 178 ++ + +LTL AI A+P + + R+ K++ G N+++ G + FWL+ Sbjct: 81 MKQWERDLTLRGAIQVSATPVFQQIAREVGEVRMQKYLKKFSYG-NQNISGGIDKFWLEG 139 Query: 179 NY-VNTIGHRAAERALQLGTLFPPAE---ALKVGLVDEVVPEDQVHSKA 223 ++ + +L L L E +K LV E PE VHSK Sbjct: 140 QLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKT 188 >3RST-A nrPDB Length = 240 Score = 27.7 bits (60), Expect = 5.7, Method: Compositional matrix adjust. Identities = 9/25 (36%), Positives = 19/25 (76%) Query: 65 FVISLEKLENDKSIRGVILTSERPG 89 F+ +LE+ ++DK+++G++L PG Sbjct: 34 FLKNLERAKDDKTVKGIVLKVNSPG 58 >4KWB-A nrPDB Length = 273 Score = 27.7 bits (60), Expect = 5.8, Method: Compositional matrix adjust. Identities = 9/25 (36%), Positives = 19/25 (76%) Query: 65 FVISLEKLENDKSIRGVILTSERPG 89 F+ +LE+ ++DK+++G++L PG Sbjct: 39 FLKNLERAKDDKTVKGIVLKVNSPG 63 >2XFR-A nrPDB Length = 535 Score = 27.7 bits (60), Expect = 6.0, Method: Compositional matrix adjust. Identities = 17/53 (32%), Positives = 24/53 (45%), Gaps = 7/53 (13%) Query: 230 WFTIPDHSRQLTKSMMRKATADN------LIKQREADIQNFTSFISRDSIQKS 276 W+ +P H+ +LT D ++K+ A I NFT RDS Q S Sbjct: 300 WYKVPSHAAELTAGYYNLHDRDGYRTIARMLKRHRASI-NFTCAEMRDSEQSS 351 >6H7W-Q nrPDB Length = 846 Score = 27.3 bits (59), Expect = 8.7, Method: Compositional matrix adjust. Identities = 20/73 (27%), Positives = 34/73 (46%), Gaps = 3/73 (4%) Query: 88 PGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNL-TLISAINGASPAGGCLMAL 146 P + +AGL L + + HY + W + + S + TL + +NG A CL L Sbjct: 592 PPLITAGLKLARRF-KAREHYDDNWSSQSSSLFKFLHSAISTLYTRVNGPGVADLCLR-L 649 Query: 147 TCDYRIMADNSKY 159 C +AD +++ Sbjct: 650 FCSCGQVADMTEF 662 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1XX4-A nrPDB 317 4e-87 5ZAI-A nrPDB 281 2e-76 5Z7R-A nrPDB 279 1e-75 2DUB-A nrPDB 277 3e-75 2HW5-A nrPDB 276 9e-75 3H81-A nrPDB 258 2e-69 2PPY-A nrPDB 251 2e-67 3MOY-A nrPDB 241 2e-64 2IEX-A nrPDB 238 3e-63 4FZW-A nrPDB 236 9e-63 3T88-A nrPDB 228 3e-60 1NZY-B nrPDB 227 3e-60 5WYB-B nrPDB 226 9e-60 2UZF-A nrPDB 224 5e-59 5VE2-A nrPDB 208 3e-54 5JBW-A nrPDB 207 6e-54 2VSU-C nrPDB 206 8e-54 5YLO-A nrPDB 195 2e-50 3OME-A nrPDB 188 2e-48 1EF9-A nrPDB 187 4e-48 4JCS-A nrPDB 185 2e-47 5ZRV-A nrPDB 184 3e-47 4J2U-A nrPDB 180 8e-46 3I47-A nrPDB 174 3e-44 6IUM-B nrPDB 173 7e-44 2D3T-A nrPDB 170 5e-43 2WTB-A nrPDB 168 2e-42 3ZWA-A nrPDB 166 7e-42 4IZC-A nrPDB 161 3e-40 3HE2-A nrPDB 159 2e-39 4ZU2-A nrPDB 158 3e-39 4JSB-A nrPDB 145 1e-35 4HDT-A nrPDB 144 3e-35 3HP0-A nrPDB 144 6e-35 4B3J-A nrPDB 141 4e-34 Sequences not found previously or not previously below threshold: 4EML-A nrPDB 208 2e-54 6OJM-A nrPDB 187 6e-48 4JWV-A nrPDB 167 7e-42 3T8B-A nrPDB 160 4e-40 4FZW-C nrPDB 160 8e-40 3HIN-A nrPDB 154 3e-38 4JFC-A nrPDB 152 2e-37 2A81-A nrPDB 142 2e-34 5KJP-A nrPDB 141 4e-34 3BPT-A nrPDB 137 5e-33 3LAO-A nrPDB 131 4e-31 5MRE-88 nrPDB 122 3e-28 4Q1J-A nrPDB 114 5e-26 2NP9-A nrPDB 103 1e-22 4HC8-A nrPDB 99 2e-21 3JU1-A nrPDB 99 2e-21 3M6N-A nrPDB 95 5e-20 4ZDC-A nrPDB 68 4e-12 3BF0-A nrPDB 36 0.015 2WWR-A nrPDB 33 0.13 6FAH-B nrPDB 32 0.48 3FK4-A nrPDB 31 0.73 2JIS-A nrPDB 30 0.85 3DO6-A nrPDB 30 1.0 6EM4-v nrPDB 30 1.1 4R6L-A nrPDB 30 1.4 6F73-A nrPDB 30 1.5 6N2Y-G nrPDB 30 1.7 3N6R-B nrPDB 28 3.7 5N4B-A nrPDB 28 4.1 4IKY-A nrPDB 28 4.2 4Q28-A nrPDB 28 4.5 6H7W-Q nrPDB 28 4.5 3CB4-D nrPDB 28 4.6 2C8T-A nrPDB 28 4.8 3IBB-A nrPDB 28 5.7 5ZF1-A nrPDB 28 6.7 1SKF-A nrPDB 27 8.3 >1XX4-A nrPDB Length = 261 Score = 317 bits (812), Expect = 4e-87, Method: Composition-based stats. Identities = 261/261 (100%), Positives = 261/261 (100%) Query: 29 FSNKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERP 88 FSNKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERP Sbjct: 1 FSNKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERP 60 Query: 89 GIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTC 148 GIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTC Sbjct: 61 GIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTC 120 Query: 149 DYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVG 208 DYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVG Sbjct: 121 DYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVG 180 Query: 209 LVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFI 268 LVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFI Sbjct: 181 LVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFI 240 Query: 269 SRDSIQKSLHVYLEKLKQKKG 289 SRDSIQKSLHVYLEKLKQKKG Sbjct: 241 SRDSIQKSLHVYLEKLKQKKG 261 >5ZAI-A nrPDB Length = 259 Score = 281 bits (719), Expect = 2e-76, Method: Composition-based stats. Identities = 64/258 (24%), Positives = 115/258 (44%), Gaps = 6/258 (2%) Query: 29 FSNKRVLVEKEGEAGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSER 87 + + +KEG + + P +N+L+ + L E ++ + E+D IR +I+T + Sbjct: 1 MEFETIETKKEG--NLFWITLNRPDKLNALNAKLLEELDRAVSQAESDPEIRVIIITG-K 57 Query: 88 PGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALT 147 F AG D+ + PA ++ K +E+ ++ + I+ ING + GG +AL Sbjct: 58 GKAFCAGADITQFNQLTPAEAWKFSKKGREIMDKIEALSKPTIAMINGYALGGGLELALA 117 Query: 148 CDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKV 207 CD RI A+ ++ +GL E LGI + IG A + G P +A K Sbjct: 118 CDIRIAAEEAQ--LGLPEINLGIYPGYGGTQRLTRVIGKGRALEMMMTGDRIPGKDAEKY 175 Query: 208 GLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSF 267 GLV+ VVP + + R + K S L K ++ + L+ + + Sbjct: 176 GLVNRVVPLANLEQETRKLAEKIAKKSPISLALIKEVVNRGLDSPLLSGLALESVGWGVV 235 Query: 268 ISRDSIQKSLHVYLEKLK 285 S + ++ + +LEK + Sbjct: 236 FSTEDKKEGVSAFLEKRE 253 >5Z7R-A nrPDB Length = 267 Score = 279 bits (714), Expect = 1e-75, Method: Composition-based stats. Identities = 67/258 (25%), Positives = 126/258 (48%), Gaps = 5/258 (1%) Query: 29 FSNKRVLVEKEGEAGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSER 87 V++EKEG+ +AV+ P +N+L+ + L E + ++END + VILT Sbjct: 1 MELNNVILEKEGK--VAVVTINRPKALNALNSDTLKEMDYVIGEIENDSEVLAVILTGAG 58 Query: 88 PGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALT 147 F AG D+ EM N ++ +++ RL L +I+A+NG + GGC +A++ Sbjct: 59 EKSFVAGADISEMKEMNTIEGRKFGILGNKVFRRLELLEKPVIAAVNGFALGGGCEIAMS 118 Query: 148 CDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKV 207 CD RI + N+++ G E LGI F +G A++ + EAL++ Sbjct: 119 CDIRIASSNARF--GQPEVGLGITPGFGGTQRLSRLVGMGMAKQLIFTAQNIKADEALRI 176 Query: 208 GLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSF 267 GLV++VV ++ + A+ + K + + +L+K + + ++ + + F Sbjct: 177 GLVNKVVEPSELMNTAKEIANKIVSNAPVAVKLSKQAINRGMQCDIDTALAFESEAFGEC 236 Query: 268 ISRDSIQKSLHVYLEKLK 285 S + + ++ ++EK K Sbjct: 237 FSTEDQKDAMTAFIEKRK 254 >2DUB-A nrPDB Length = 261 Score = 277 bits (709), Expect = 3e-75, Method: Composition-based stats. Identities = 56/254 (22%), Positives = 108/254 (42%), Gaps = 7/254 (2%) Query: 34 VLVEKEGE-AGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIF 91 ++ EK+G+ + + +++ P +N+L + E +LE E D ++ ++LT F Sbjct: 7 IITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAVGAIVLTG-GEKAF 65 Query: 92 SAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYR 151 +AG D+ EM R Y W + +I+A+NG + GGC +A+ CD Sbjct: 66 AAGADIKEMQNRT--FQDCYSGKFLSHWDHITRIKKPVIAAVNGYALGGGCELAMMCDII 123 Query: 152 IMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVD 211 + +++ G E LLG + +G A + G +A + GLV Sbjct: 124 YAGEKAQF--GQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVS 181 Query: 212 EVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRD 271 ++ P + + +A K + K + A L + + + + F S + D Sbjct: 182 KIFPVETLVEEAIQCAEKIANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTFATD 241 Query: 272 SIQKSLHVYLEKLK 285 ++ + ++EK K Sbjct: 242 DRREGMSAFVEKRK 255 >2HW5-A nrPDB Length = 286 Score = 276 bits (705), Expect = 9e-75, Method: Composition-based stats. Identities = 54/258 (20%), Positives = 111/258 (43%), Gaps = 7/258 (2%) Query: 30 SNKRVLVEKEGEAG-IAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSER 87 + + ++ EK G+ + +++ P +N+L + E +L+ E D ++ ++LT Sbjct: 28 NFEYIIAEKRGKNNTVGLIQLNRPKALNALCDGLIDELNQALKIFEEDPAVGAIVLTG-G 86 Query: 88 PGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALT 147 F+AG D+ EM +N + Y + W L +I+A+NG + GGC +A+ Sbjct: 87 DKAFAAGADIKEM--QNLSFQDCYSSKFLKHWDHLTQVKKPVIAAVNGYAFGGGCELAMM 144 Query: 148 CDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKV 207 CD + +++ E L+G + +G A + G +A + Sbjct: 145 CDIIYAGEKAQF--AQPEILIGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQA 202 Query: 208 GLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSF 267 GLV ++ P + + +A K + + K + A L + + + + F S Sbjct: 203 GLVSKICPVETLVEEAIQCAEKIASNSKIVVAMAKESVNAAFEMTLTEGSKLEKKLFYST 262 Query: 268 ISRDSIQKSLHVYLEKLK 285 + D ++ + ++EK K Sbjct: 263 FATDDRKEGMTAFVEKRK 280 >3H81-A nrPDB Length = 278 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 63/261 (24%), Positives = 116/261 (44%), Gaps = 8/261 (3%) Query: 25 GARRFSNKRVLVEKEGEAGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVIL 83 G + + +LVE++ GI + P +N+L+ + + E + +L++D I +I+ Sbjct: 18 GPGSMTYETILVERDQRVGI--ITLNRPQALNALNSQVMNEVTSAATELDDDPDIGAIII 75 Query: 84 TSERPGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCL 143 T F+AG D+ EM + + W +L I+A+ G + GGC Sbjct: 76 TGSAK-AFAAGADIKEMA--DLTFADAFTADFFATWGKLAAVRTPTIAAVAGYALGGGCE 132 Query: 144 MALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAE 203 +A+ CD I AD +K+ G E LG++ IG A + G AE Sbjct: 133 LAMMCDVLIAADTAKF--GQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTMDAAE 190 Query: 204 ALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQN 263 A + GLV VVP D + ++AR+ + + ++ K + +A +L + + + Sbjct: 191 AERSGLVSRVVPADDLLTEARATATTISQMSASAARMAKEAVNRAFESSLSEGLLYERRL 250 Query: 264 FTSFISRDSIQKSLHVYLEKL 284 F S + + + + ++EK Sbjct: 251 FHSAFATEDQSEGMAAFIEKR 271 >2PPY-A nrPDB Length = 265 Score = 251 bits (642), Expect = 2e-67, Method: Composition-based stats. Identities = 65/245 (26%), Positives = 103/245 (42%), Gaps = 1/245 (0%) Query: 41 EAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEM 100 E GIA + NS LEF EF +++ + D I+ VI+ S+ P FSAG D+ + Sbjct: 16 EDGIAEIHLHINKSNSYDLEFYKEFNAAIDDIRFDPDIKVVIVMSDVPKFFSAGADINFL 75 Query: 101 YGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYT 160 +P ++ E ++ S I+ + G + GG MAL CD R M D + Sbjct: 76 RSADPRFKTQFCLFCNETLDKIARSPQVYIACLEGHTVGGGLEMALACDLRFMGDEAG-K 134 Query: 161 IGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVH 220 IGL E LG++A IG+ A G P EAL++GLV+ V P+ + Sbjct: 135 IGLPEVSLGVLAGTGGTQRLARLIGYSRALDMNITGETITPQEALEIGLVNRVFPQAETR 194 Query: 221 SKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQKSLHVY 280 + R K ++ K + L + + + ++ L + Sbjct: 195 ERTREYARKLANSATYAVSNIKLAIMNGKEMPLNVAIRYEGELQNLLFRSEDAKEGLSAF 254 Query: 281 LEKLK 285 LEK + Sbjct: 255 LEKRQ 259 >3MOY-A nrPDB Length = 263 Score = 241 bits (616), Expect = 2e-64, Method: Composition-based stats. Identities = 56/261 (21%), Positives = 103/261 (39%), Gaps = 6/261 (2%) Query: 25 GARRFSNKRVLVEKEGEAGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVIL 83 G + + AG+ +++ P +N+L+ E + + + D I +++ Sbjct: 1 GPGSMTTYTTIATSRPVAGVGLIRLDRPDALNALNQTLEAEVLDAARDFDADLEIGAIVV 60 Query: 84 TSERPGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCL 143 T F+AG D+ EM P E + + W L +++A+ G + GGC Sbjct: 61 TGS-ERAFAAGADIAEMVTLTPHQARE--RNLLSGWDSLTQVRKPIVAAVAGYALGGGCE 117 Query: 144 MALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAE 203 +A+ CD I AD +++ G E LGI+ +G A G E Sbjct: 118 LAMLCDLVIAADTARF--GQPEITLGILPGLGGTQRLTRAVGKAKAMDLCLTGRSLTAEE 175 Query: 204 ALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQN 263 A +VGLV +VP + +A +V + + + + K + +A L + Sbjct: 176 AERVGLVSRIVPAADLLDEALAVAQRIARMSRPAGRAVKDAINEAFERPLSAGMRYERDA 235 Query: 264 FTSFISRDSIQKSLHVYLEKL 284 F + + + +LEK Sbjct: 236 FYAMFDTHDQTEGMTAFLEKR 256 >2IEX-A nrPDB Length = 272 Score = 238 bits (606), Expect = 3e-63, Method: Composition-based stats. Identities = 54/262 (20%), Positives = 107/262 (40%), Gaps = 9/262 (3%) Query: 27 RRFSNKRVLVEKEGEAGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTS 85 +++ + ++ E GIA + P V N+ + + E + + K +D +I +ILT Sbjct: 7 KQYDYEDIIYETY--NGIAKITINRPEVHNAFRPKTVNEMIDAFTKARDDSNIGVIILTG 64 Query: 86 ERPGIFSAGLDLM-EMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLM 144 F +G D +G V +L + + +I+ + G + GG ++ Sbjct: 65 AGGKAFCSGGDQKVRGHGGYVGEDEIPRLNVLDLQRLIRVIPKPVIAMVAGYAIGGGHVL 124 Query: 145 ALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEA 204 + CD I ADN+ + G +G + +GH+ A L + EA Sbjct: 125 HVVCDLTIAADNAIF--GQTGPKVGSFDGGYGAGYLARIVGHKKAREIWYLCRQYTAQEA 182 Query: 205 LKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRK-ATADNLIKQREADIQN 263 L++GLV++VVP +Q+ + + + + K+ + I+Q D Sbjct: 183 LEMGLVNKVVPLEQLEEETVKWAQEILEKSPTAIRFLKAAFNADSDGLAGIQQLAGDATL 242 Query: 264 FTSFISRDSIQKSLHVYLEKLK 285 F + + ++ + + EK K Sbjct: 243 L--FYTTEEAKEGMRAFKEKRK 262 >4FZW-A nrPDB Length = 258 Score = 236 bits (602), Expect = 9e-63, Method: Composition-based stats. Identities = 66/256 (25%), Positives = 113/256 (44%), Gaps = 8/256 (3%) Query: 30 SNKRVLVEKEGEAGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERP 88 S ++V ++ + ++ P N+L+ L + V LE D SI ++T Sbjct: 3 SMSELIVSRQQR--VLLLTLNRPAARNALNNALLMQLVNELEAAATDTSISVCVITGNA- 59 Query: 89 GIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTC 148 F+AG DL EM ++ A A +LW RL N LI+A+NG + GC +AL C Sbjct: 60 RFFAAGADLNEMAEKDLA--ATLNDTRPQLWARLQAFNKPLIAAVNGYALGAGCELALLC 117 Query: 149 DYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVG 208 D + +N+++ GL E LGI+ + ++G A + + G +A + G Sbjct: 118 DVVVAGENARF--GLPEITLGIMPGAGGTQRLIRSVGKSLASKMVLSGESITAQQAQQAG 175 Query: 209 LVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFI 268 LV +V P D A + +K + Q K +R++ L + Q FT Sbjct: 176 LVSDVFPSDLTLEYALQLASKMARHSPLALQAAKQALRQSQEVALQAGLAQERQLFTLLA 235 Query: 269 SRDSIQKSLHVYLEKL 284 + + + + +L+K Sbjct: 236 ATEDRHEGISAFLQKR 251 >3T88-A nrPDB Length = 289 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 50/259 (19%), Positives = 95/259 (36%), Gaps = 9/259 (3%) Query: 31 NKRVLVEKEGEAGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPG 89 + + EK GIA + P V N+ + E + +L D +I +ILT Sbjct: 26 FEDIRYEKS-TDGIAKITINRPQVRNAFRPLTVKEMIQALADARYDDNIGVIILTGAGDK 84 Query: 90 IFSAGLD--LMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALT 147 F +G D + YG + V + ++ +++ + G S GG ++ + Sbjct: 85 AFCSGGDQKVRGDYGGYKDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMM 144 Query: 148 CDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKV 207 CD I ADN+ + G +G W +G + A L + +AL + Sbjct: 145 CDLTIAADNAIF--GQTGPKVGSFDGGWGASYMARIVGQKKAREIWFLCRQYDAKQALDM 202 Query: 208 GLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQR-EADIQNFTS 266 GLV+ VVP + + + + + K+ + + E Sbjct: 203 GLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNA--DCDGQAGLQELAGNATML 260 Query: 267 FISRDSIQKSLHVYLEKLK 285 F + Q+ + + +K + Sbjct: 261 FYMTEEGQEGRNAFNQKRQ 279 >1NZY-B nrPDB Length = 269 Score = 227 bits (580), Expect = 3e-60, Method: Composition-based stats. Identities = 58/248 (23%), Positives = 106/248 (42%), Gaps = 9/248 (3%) Query: 41 EAGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLME 99 E G+A + K P N+LS++ + E +L + E D S+ V++T F AG L E Sbjct: 10 EDGVAEITIKLPRHRNALSVKAMQEVTDALNRAEEDDSVGAVMITGAED-AFCAGFYLRE 68 Query: 100 MY-GRNPAHYAEYWKAV----QELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMA 154 + + A ++++ ++ ++ +++AING + GG ++L D I A Sbjct: 69 IPLDKGVAGVRDHFRIAALWWHQMIHKIIRVKRPVLAAINGVAAGGGLGISLASDMAICA 128 Query: 155 DNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVV 214 D++K+ + +GI + +G R A + P EA GLV V Sbjct: 129 DSAKFVCAWH--TIGIGNDTATSYSLARIVGMRRAMELMLTDRTLYPEEAKDWGLVSRVY 186 Query: 215 PEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQ 274 P+D+ A V + P H + + K + + E +IQN + ++ Sbjct: 187 PKDEFREVAWKVARELAAAPTHLQVMAKERFHAGWMQPVEECTEFEIQNVIASVTHPHFM 246 Query: 275 KSLHVYLE 282 L +L+ Sbjct: 247 PCLTRFLD 254 >5WYB-B nrPDB Length = 280 Score = 226 bits (576), Expect = 9e-60, Method: Composition-based stats. Identities = 61/255 (23%), Positives = 106/255 (41%), Gaps = 4/255 (1%) Query: 33 RVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFS 92 ++ VEK G A++ +PP N+ + L +E L D I +++T + P FS Sbjct: 18 KLTVEKHGH--TALITINHPPANTWDRDSLIGLRQLIEHLNRDDDIYALVVTGQGPKFFS 75 Query: 93 AGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRI 152 AG DL + A E + E + L I+AING + GG AL CD RI Sbjct: 76 AGADLNMFADGDKARAREMARRFGEAFEALRDFRGVSIAAINGYAMGGGLECALACDIRI 135 Query: 153 MADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDE 212 ++ + L E+ +G++ +G A+R + AL++GLV++ Sbjct: 136 AERQAQ--MALPEAAVGLLPCAGGTQALPWLVGEGWAKRMILCNERVDAETALRIGLVEQ 193 Query: 213 VVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDS 272 VV + A + AK + + K +++ A + + F Sbjct: 194 VVDSGEARGAALLLAAKVARQSPVAIRTIKPLIQGARERAPNTWLPEERERFVDLFDAQD 253 Query: 273 IQKSLHVYLEKLKQK 287 ++ ++ +LEK K Sbjct: 254 TREGVNAFLEKRDPK 268 >2UZF-A nrPDB Length = 273 Score = 224 bits (570), Expect = 5e-59, Method: Composition-based stats. Identities = 52/252 (20%), Positives = 103/252 (40%), Gaps = 7/252 (2%) Query: 36 VEKEGEAGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAG 94 ++ E GIA + P V N+ + + + E + + + +D+++ ++LT E F +G Sbjct: 15 IKYEFYEGIAKVTINRPEVRNAFTPKTVAEMIDAFSRARDDQNVSVIVLTGEGDLAFCSG 74 Query: 95 LDLMEM-YGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIM 153 D + +G V +L + + +I+ + G + GG ++ + CD I Sbjct: 75 GDQKKRGHGGYVGEDQIPRLNVLDLQRLIRIIPKPVIAMVKGYAVGGGNVLNVVCDLTIA 134 Query: 154 ADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEV 213 ADN+ + G +G + +GH+ A L + EAL +GLV+ V Sbjct: 135 ADNAIF--GQTGPKVGSFDAGYGSGYLARIVGHKKAREIWYLCRQYNAQEALDMGLVNTV 192 Query: 214 VPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATA-DNLIKQREADIQNFTSFISRDS 272 VP ++V + + + + K+ M T ++Q D + D Sbjct: 193 VPLEKVEDETVQWCKEIMKHSPTALRFLKAAMNADTDGLAGLQQMAGDATLLY--YTTDE 250 Query: 273 IQKSLHVYLEKL 284 ++ + EK Sbjct: 251 AKEGRDAFKEKR 262 >4EML-A nrPDB Length = 275 Score = 208 bits (530), Expect = 2e-54, Method: Composition-based stats. Identities = 50/262 (19%), Positives = 91/262 (34%), Gaps = 14/262 (5%) Query: 31 NKRVLVEKEGEAGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPG 89 +L K G GIA + P N+ + + E + D I V+LT P Sbjct: 9 YDDILYYKAG--GIAKIVINRPHKRNAFRPQTVFELYDAFCNAREDNRIGVVLLTGAGPH 66 Query: 90 -----IFSAGLDL-MEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCL 143 F +G D + G V +L + +I+ + G + GG + Sbjct: 67 SDGKYAFCSGGDQSVRGEGGYIDDQGTPRLNVLDLQRLIRSMPKVVIALVAGYAIGGGHV 126 Query: 144 MALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAE 203 + L CD I ADN+ + G +G + +G + A L + E Sbjct: 127 LHLVCDLTIAADNAIF--GQTGPKVGSFDGGFGSSYLARIVGQKKAREIWYLCRQYSAQE 184 Query: 204 ALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQR-EADIQ 262 A ++G+V+ VVP D++ + + + + + K+ + E Sbjct: 185 AERMGMVNTVVPVDRLEEEGIQWAKEILSKSPLAIRCLKAAFNA--DCDGQAGLQELAGN 242 Query: 263 NFTSFISRDSIQKSLHVYLEKL 284 + + + +LEK Sbjct: 243 ATLLYYMTEEGSEGKQAFLEKR 264 >5VE2-A nrPDB Length = 275 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 49/242 (20%), Positives = 100/242 (41%), Gaps = 7/242 (2%) Query: 44 IAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYG 102 + + P + N+L+ E LE+ +D IR V+LT+ F+AG DL + Sbjct: 35 VLSLTINRPELKNALNRELYAALADELERSNHDDQIRAVLLTANGD-TFTAGNDLDDFI- 92 Query: 103 RNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTIG 162 NP + +V + ++ A+NG + G M L CD + ++++ Sbjct: 93 -NPVEESGTP-SVIRFLKAISECETPIVVAVNGPAIGVGLTMLLHCDMVYASKSARFRAP 150 Query: 163 LNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVHSK 222 G+V +G A + G + EAL GLV V +D + ++ Sbjct: 151 FTHV--GLVPEAASSLLLPLAVGQAWANDLMLAGRILDAREALSAGLVTRVFEDDVLVAE 208 Query: 223 ARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQKSLHVYLE 282 + + + ++ +S + +K ++R + + Q + + F ++ ++S+ + E Sbjct: 209 SLKIAEQVASLAPNSVKQSKRLIRGVNKEEVQAQMKREGVIFAEQLASAEFKESVAAFFE 268 Query: 283 KL 284 K Sbjct: 269 KR 270 >5JBW-A nrPDB Length = 260 Score = 207 bits (526), Expect = 6e-54, Method: Composition-based stats. Identities = 51/230 (22%), Positives = 94/230 (40%), Gaps = 2/230 (0%) Query: 55 NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRNPAHYAEYWKA 114 N++S L E + ++ + + +R V++T F AG DL E + Sbjct: 26 NAISRAMLKELGELVTRVSSSRDVRAVVITGAGDKAFCAGADLKERATMAEDEVRAFLDG 85 Query: 115 VQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPF 174 ++ + + S+ I+AINGA+ GG +AL CD R+ A ++ +GL E LGI+ Sbjct: 86 LRRTFRAIEKSDCVFIAAINGAALGGGTELALACDLRVAAPAAE--LGLTEVKLGIIPGG 143 Query: 175 WLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVHSKARSVMAKWFTIP 234 +G A+ + AEA VGL + + PE + + A + Sbjct: 144 GGTQRLARLVGPGRAKDLILTARRINAAEAFSVGLANRLAPEGHLLAVAYGLAESVVENA 203 Query: 235 DHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQKSLHVYLEKL 284 + K + + T L +++ + + + + L + EK Sbjct: 204 PIAVATAKHAIDEGTGLELDDALALELRKYEEILKTEDRLEGLRAFAEKR 253 >2VSU-C nrPDB Length = 275 Score = 206 bits (525), Expect = 8e-54, Method: Composition-based stats. Identities = 61/263 (23%), Positives = 104/263 (39%), Gaps = 11/263 (4%) Query: 35 LVEKEGEAGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSA 93 V+ E E GIA + P N++S E + LE LE D + ++LT ++A Sbjct: 10 TVKVEIEDGIAFVILNRPEKRNAMSPTLNREMIDVLETLEQDPAAGVLVLTGAG-EAWTA 68 Query: 94 GLDLMEMY---GRNPAHYAEYWK--AVQELWLRLYLSNLTLISAINGASPAGGCLMALTC 148 G+DL E + P E + A Q W L + I+ +NG GG + C Sbjct: 69 GMDLKEYFREVDAGPEILQEKIRREASQWQWKLLRMYAKPTIAMVNGWCFGGGFAPLVAC 128 Query: 149 DYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVG 208 D I AD + + GL+E GI + +T+GHR + + G F +A ++G Sbjct: 129 DLAICADEATF--GLSEINWGIPPGNLVSKAMADTVGHRQSLYYIMTGKTFGGQKAAEMG 186 Query: 209 LVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLI--KQREADIQNFTS 266 LV+E VP Q+ + + K ++ + + + Sbjct: 187 LVNESVPLAQLREVTIELARNLLEKNPVVLRAAKHGFKRCRELTWEQNEDYLYAKLDQSR 246 Query: 267 FISRDSIQKSLHVYLEKLKQKKG 289 + ++ + +L+ K G Sbjct: 247 LLDTGGREQGMKQFLDDKSIKPG 269 >5YLO-A nrPDB Length = 271 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 63/253 (24%), Positives = 107/253 (42%), Gaps = 7/253 (2%) Query: 36 VEKEGEAGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAG 94 ++ EAGIA + P N+L + L + L+ E D ++R V+L F AG Sbjct: 7 LQTRVEAGIAWLVLNRPQQRNALDIPTLEALHVRLDACERDPAVRAVVL-GGSGRSFCAG 65 Query: 95 LDLME---MYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYR 151 DL E R + +A L RL+ + ++A+NG++ G +AL CD+R Sbjct: 66 ADLAEWAAAEARGELESYGWTEAAHALMGRLHALDKPTVAAVNGSAVGAGMDLALCCDFR 125 Query: 152 IMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVD 211 I A ++++ G + +G AA+R L L + AL GLV Sbjct: 126 IAAASARFKAGYTGMAY--CPDAGASWHLPRLLGSEAAKRLLFLDEAWSAERALGAGLVG 183 Query: 212 EVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRD 271 EVV ++ + + A+ + P + TK ++R +L +Q A+ + Sbjct: 184 EVVADEHLVEAVGAFAARLASGPTFAFAQTKRLLRDGAGRSLAEQLRAEQAAGLLCGRSE 243 Query: 272 SIQKSLHVYLEKL 284 ++L EK Sbjct: 244 DAAEALRAVAEKR 256 >3OME-A nrPDB Length = 282 Score = 188 bits (478), Expect = 2e-48, Method: Composition-based stats. Identities = 49/232 (21%), Positives = 91/232 (39%), Gaps = 15/232 (6%) Query: 25 GARRFSNKRVLVEKEGEAGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVIL 83 G V IA + P N+ + E L E + + D ++ +IL Sbjct: 18 GPGSMVYIDYGV----ADSIATITLNRPEAANAQNPELLDELDAAWTRAAEDNEVKVIIL 73 Query: 84 TSERPGIFSAGLDLMEMYGRNPAHYAEYW-----KAVQELWLRLYLSNLTLISAINGASP 138 + FSAG DL E+ + + LR I+A+ G Sbjct: 74 RANGKH-FSAGHDLRGGGEVPEKISLEFIIQHEARRYLDYTLRWRNVPKPSIAAVQGRCI 132 Query: 139 AGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTL 198 +GG L+ CD + +D++ ++ +L+GI + + +G R A+ L G Sbjct: 133 SGGLLLCWPCDLILASDDALFSD--PVALMGIGGVEYHGHTW--ELGPRKAKEILFTGRA 188 Query: 199 FPPAEALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATA 250 EA + G+V+ VV D++ ++ R + + T+P + + K + + Sbjct: 189 LTAEEAERTGMVNRVVARDELDAQTRELAEQIATMPPFALRQAKRAVNQTLD 240 >1EF9-A nrPDB Length = 261 Score = 187 bits (476), Expect = 4e-48, Method: Composition-based stats. Identities = 52/256 (20%), Positives = 103/256 (40%), Gaps = 12/256 (4%) Query: 36 VEKEGEAGIAVMKFK-NPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTS-ERPGIFSA 93 V +AV++F +N+LS F+ + + +L L N IR +IL + +FSA Sbjct: 6 VNVVTINKVAVIEFNYGRKLNALSKVFIDDLMQALSDL-NRPEIRCIILRAPSGSKVFSA 64 Query: 94 GLDLMEMY--GRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYR 151 G D+ E+ GR+P Y + + + + + +IS + G+ G M ++ D Sbjct: 65 GHDIHELPSGGRDPLSYDDPLRQITRM---IQKFPKPIISMVEGSVWGGAFEMIMSSDLI 121 Query: 152 IMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVD 211 I A S ++ + LG+ N G + + + AL VG+++ Sbjct: 122 IAASTSTFS--MTPVNLGVPYNLVGIHNLTRDAGFHIVKELIFTASPITAQRALAVGILN 179 Query: 212 EVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQ--NFTSFIS 269 VV +++ + + + K +R + + E + + Sbjct: 180 HVVEVEELEDFTLQMAHHISEKAPLAIAVIKEELRVLGEAHTMNSDEFERIQGMRRAVYD 239 Query: 270 RDSIQKSLHVYLEKLK 285 + Q+ ++ +LEK K Sbjct: 240 SEDYQEGMNAFLEKRK 255 >6OJM-A nrPDB Length = 286 Score = 187 bits (474), Expect = 6e-48, Method: Composition-based stats. Identities = 48/268 (17%), Positives = 101/268 (37%), Gaps = 14/268 (5%) Query: 31 NKRVLVEKEGEAGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPG 89 + + +K G+A + F P + N+ + +E + D SI V+L+ E P Sbjct: 18 YEDITYKKC--NGVARIAFNRPEIRNAFRPKTTSELYDAFYDAYEDPSIGVVLLSGEGPS 75 Query: 90 ------IFSAGLDLMEM-YGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGC 142 F +G D + + + E+ + +I+ + G + GG Sbjct: 76 PKDGGWAFCSGGDQKARGHQGYVGEDGRHRLNILEVQRLIRFMPKVVIAVVPGWAVGGGH 135 Query: 143 LMALTCDYRIMADN-SKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPP 201 + + CD + + + + ++ + + +G + A LG + Sbjct: 136 SLHVVCDLTLASKEHAIFK--QTDADVTSFDGGYGSAYLAKMVGQKKAREIFFLGRNYSA 193 Query: 202 AEALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADI 261 EA ++G+V++VVP ++ A + S ++ K M T D ++ Q+ Sbjct: 194 QEAFEMGMVNKVVPHAELEDTAYEWAQEILAKSPTSIRMLKFAMN-LTDDGMVGQQVFAG 252 Query: 262 QNFTSFISRDSIQKSLHVYLEKLKQKKG 289 + D ++ + +LEK K G Sbjct: 253 EATRLAYMTDEAKEGRNAFLEKRKPDFG 280 >4JCS-A nrPDB Length = 286 Score = 185 bits (469), Expect = 2e-47, Method: Composition-based stats. Identities = 46/247 (18%), Positives = 98/247 (39%), Gaps = 7/247 (2%) Query: 42 AGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEM 100 + ++ N E + + LE++ +D IR ++LTS PG F AG +L + Sbjct: 32 NNVGWIRMNRAAKHNPFDAELRADLMTVLERVRDDADIRVLVLTSH-PGSFCAGGNLHVL 90 Query: 101 ---YGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNS 157 PA++ + K + +I+A++G + G ++LT D + + + Sbjct: 91 RDNLDSGPAYWQQRIKTGLRFIHDMLNLGRPVIAAVDGPAFGAGFALSLTADIVLASPRA 150 Query: 158 KYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPED 217 ++++ LG+V +G + A+ + EA ++GLV EV + Sbjct: 151 RFSMAY--LRLGLVPDLGALYLLPRAVGLQRAKELMFSTRELDAEEAHRLGLVMEVHESE 208 Query: 218 QVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQKSL 277 + +AR + + LTK+ + + + + + + S + ++ Sbjct: 209 ALEQRAREIAESLVQAAPTALALTKAALNVSLDSDEQTMFSLEAASQAAAFSTKEPRAAI 268 Query: 278 HVYLEKL 284 L K Sbjct: 269 EALLSKQ 275 >5ZRV-A nrPDB Length = 763 Score = 184 bits (468), Expect = 3e-47, Method: Composition-based stats. Identities = 52/204 (25%), Positives = 88/204 (43%), Gaps = 16/204 (7%) Query: 44 IAVMKFKNP--PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMY 101 +AV++ +P VN+LS E +EF + ++ IR +L S +PG F AG D+ + Sbjct: 49 VAVVRINSPNSKVNTLSKELHSEFSEVMNEIWASDQIRSAVLISSKPGCFIAGADINMLA 108 Query: 102 G-RNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYT 160 + + + Q + +L S +++AING+ GG +A++C YRI + K Sbjct: 109 ACKTLQEVTQLSQEAQRIVEKLEKSTKPIVAAINGSCLGGGLEVAISCQYRIATKDRKTV 168 Query: 161 IGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPE---- 216 +G E LLG + +G AA + G A K+GLVD++V Sbjct: 169 LGTPEVLLGALPGAGGTQRLPKMVGVPAALDMMLTGRSIRADRAKKMGLVDQLVEPLGPG 228 Query: 217 ---------DQVHSKARSVMAKWF 231 + + A + Sbjct: 229 LKPPEERTIEYLEEVAITFAKGLA 252 >4J2U-A nrPDB Length = 365 Score = 180 bits (456), Expect = 8e-46, Method: Composition-based stats. Identities = 53/255 (20%), Positives = 97/255 (38%), Gaps = 10/255 (3%) Query: 30 SNKRVLVEKEGEAGIAVMKFKNPP-VNSLSLEFLTEFVISLEKLENDKSIRGVILTSERP 88 S VL+ K AG + P +N+L+ + E +L D + V++ +E P Sbjct: 22 SMSDVLIRKVRRAGR--ITLSRPAALNALTCAMVQEIDAALRGWIGDPEVELVVIDAEGP 79 Query: 89 GIFSAGLDLMEMYGR----NPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLM 144 F AG D+ E++GR + A ++W+ + R+ ++S + G + GG + Sbjct: 80 RAFCAGGDIAELHGRGVAGDHAFGQDFWRVEYRMNDRIAAFPKPIVSLMQGFTMGGGVGL 139 Query: 145 ALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEA 204 +RI+ + S+ I + E +G+V G G P +A Sbjct: 140 GCHARHRIVGETSQ--ISMPECAIGLVPDVGGTHLLARAPGRIGVWLG-LTGARMGPGDA 196 Query: 205 LKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNF 264 + G D VPE ++ +PDH+ + + + D L A+I Sbjct: 197 IFAGFADRFVPEADWPDLIAALEGGDLALPDHAAPEGRLPVLQDEIDRLFAGTLAEIPAR 256 Query: 265 TSFISRDSIQKSLHV 279 ++L Sbjct: 257 LEATDTPLAAEALKA 271 >3I47-A nrPDB Length = 268 Score = 174 bits (442), Expect = 3e-44, Method: Composition-based stats. Identities = 54/260 (20%), Positives = 99/260 (38%), Gaps = 11/260 (4%) Query: 29 FSNKRVLVEKEGEAGIAVMKFKN-PPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSER 87 S +L E + + ++ N+ + LTE I L+ ND ++R ++L + Sbjct: 1 MSLSDLLYE--IQDKVGLLTMNRISKHNAFDNQLLTEMRIRLDSAINDTNVRVIVLKANG 58 Query: 88 PGIFSAGLDLMEMYGR---NPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLM 144 FSAG DL M E + L + S I+ + GA+ GG + Sbjct: 59 KH-FSAGADLTWMQSMANFTEEENLEDSLVLGNLMYSISQSPKPTIAMVQGAAFGGGAGL 117 Query: 145 ALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEA 204 A CD I + ++++ +E LG++ + V IG RAA+ +F A Sbjct: 118 AAACDIAIASTSARFCF--SEVKLGLIP-AVISPYVVRAIGERAAKMLFMSAEVFDATRA 174 Query: 205 LKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQR-EADIQN 263 + LV VP+D + ++ + + +K + + + ++ Sbjct: 175 YSLNLVQHCVPDDTLLEFTLKYASQISNNAPEAVKNSKQLAQYVANKKIDEELVRYTASL 234 Query: 264 FTSFISRDSIQKSLHVYLEK 283 D Q+ L +L K Sbjct: 235 IAHKRVSDEGQEGLKAFLNK 254 >6IUM-B nrPDB Length = 701 Score = 173 bits (439), Expect = 7e-44, Method: Composition-based stats. Identities = 53/286 (18%), Positives = 103/286 (36%), Gaps = 38/286 (13%) Query: 34 VLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSA 93 + + + + G+AV+ NPPVN L V + + +D +++ +++T FS Sbjct: 1 MTAQYQVQDGVAVITLDNPPVNGLGHSTRLGIVEGMTRALDDAAVKAIVITGAGK-AFSG 59 Query: 94 GLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIM 153 G D+ E P E + + L S+ +++A++ + GG +AL C+YR+ Sbjct: 60 GADIREF--NTPKAMQEP--TLHSVIRVLEGSSKPVVAAVHSVAMGGGLELALGCNYRVA 115 Query: 154 ADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEV 213 + ++ I L E LG++ IG AA + GT + L DE+ Sbjct: 116 SKGAQ--IALPEVKLGLLPGAGGTQRLPRVIGLEAAANMIVSGTPVLSEKFAGTKLFDEI 173 Query: 214 VPEDQVHSKARSVMAKWFTIPDHS------------------RQLTKSMMRKATADNL-- 253 V D + + + H + T + M K L Sbjct: 174 VDGDVLPAAVKFAQNVGAATGPHPKVRDLKVRHENPEGYLGFARNTVAAMAKNFPAPLKC 233 Query: 254 -----------IKQREADIQNFTSFISRDSIQKSLHVYLEKLKQKK 288 + + + + F ++ + H + + K Sbjct: 234 LEAVAGSLKPFEQGLKQEREGFLYLVTTPESRALRHAFFGERAASK 279 >2D3T-A nrPDB Length = 715 Score = 170 bits (432), Expect = 5e-43, Method: Composition-based stats. Identities = 59/225 (26%), Positives = 99/225 (44%), Gaps = 8/225 (3%) Query: 41 EAGIAVMKFK--NPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLM 98 E+GI +KF VN + L E +++ ++ D S++GVI+ S +F G D+ Sbjct: 14 ESGIVELKFDLKGESVNKFNRLTLNELRQAVDAIKADASVKGVIV-SSGKDVFIVGADIT 72 Query: 99 EMYGRNPAHYAEYW---KAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMAD 155 E AE +++ N+ ++AING + GG M L D+R+MAD Sbjct: 73 EFVENFKLPDAELIAGNLEANKIFSDFEDLNVPTVAAINGIALGGGLEMCLAADFRVMAD 132 Query: 156 NSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVP 215 ++K IGL E LGI F IG A + G +ALKV VD VV Sbjct: 133 SAK--IGLPEVKLGIYPGFGGTVRLPRLIGVDNAVEWIASGKENRAEDALKVSAVDAVVT 190 Query: 216 EDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREAD 260 D++ + A ++ + + + + + K + + + + Sbjct: 191 ADKLGAAALDLIKRAISGELDYKAKRQPKLEKLKLNAIEQMMAFE 235 >2WTB-A nrPDB Length = 725 Score = 168 bits (426), Expect = 2e-42, Method: Composition-based stats. Identities = 51/196 (26%), Positives = 88/196 (44%), Gaps = 6/196 (3%) Query: 35 LVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAG 94 V + G G+AV+ NPPVNSLS + L + E+ + ++ +++T + FS G Sbjct: 9 TVMEVGGDGVAVITLINPPVNSLSFDVLYNLKSNYEEALSRNDVKAIVITGAKGR-FSGG 67 Query: 95 LDLM---EMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYR 151 D+ EM N + ++ + L + ++AI+G + GG +A+ C R Sbjct: 68 FDISGFGEMQKGNVKEPKAGYISIDIITDLLEAARKPSVAAIDGLALGGGLELAMACHAR 127 Query: 152 IMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVD 211 I A ++ +GL E LG++ F +G A + E +GL+D Sbjct: 128 ISAPAAQ--LGLPELQLGVIPGFGGTQRLPRLVGLTKALEMILTSKPVKAEEGHSLGLID 185 Query: 212 EVVPEDQVHSKARSVM 227 VVP ++ + AR Sbjct: 186 AVVPPAELVTTARRWA 201 >4JWV-A nrPDB Length = 278 Score = 167 bits (422), Expect = 7e-42, Method: Composition-based stats. Identities = 47/257 (18%), Positives = 96/257 (37%), Gaps = 7/257 (2%) Query: 30 SNKRVLVEKEGEAGIAVMKFKNPP-VNSLSLEFLTEFVISLEKLENDKSIRGVILTSERP 88 S + EG +A ++ P +N+++ E + + ++ + I V+L++E Sbjct: 22 SMADIDFRIEGH--VAHVRLNRPQGLNAITQEMDDLLLDAWTEVNANSDIWAVVLSAEGE 79 Query: 89 GIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTC 148 F G D+ R L +++A+ G GG +A+ Sbjct: 80 KAFCIGADVSGGAERKTRMALGGGLTGIGGPL--VTCKKPMVAAVQGFCVGGGFELAMCA 137 Query: 149 DYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVG 208 D + AD +++ GL E+ +GI+ + + + + A + + G EA G Sbjct: 138 DIIVAADTAQF--GLPETKVGIIGECGVVHRAMRQLPYHIALQLILTGERIKADEARHYG 195 Query: 209 LVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFI 268 LV+EVVP ++ A +K + Q K+ L + + Sbjct: 196 LVNEVVPFAELEEAALRWASKLNAASPLAVQAAKAAALGRLGHPLEVALMTRFEPIEEYA 255 Query: 269 SRDSIQKSLHVYLEKLK 285 + + ++ E+ K Sbjct: 256 ATEDKKEGERAAGERRK 272 >3ZWA-A nrPDB Length = 742 Score = 166 bits (421), Expect = 7e-42, Method: Composition-based stats. Identities = 53/192 (27%), Positives = 86/192 (44%), Gaps = 10/192 (5%) Query: 43 GIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYG 102 +A+++ NPPVN++S + E L+K +D +++ +++ G F AG D+ Sbjct: 30 SLAMIRLCNPPVNAVSPTVIREVRNGLQKAGSDHTVKAIVICGAN-GNFCAGADIHGFSA 88 Query: 103 RNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTIG 162 P A+ L + +++AI G + GG +AL C YRI N+K +G Sbjct: 89 FTPG------LALGSLVDEIQRYQKPVLAAIQGVALGGGLELALGCHYRIA--NAKARVG 140 Query: 163 LNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVHSK 222 L E LGI+ +G A + G EAL++G++D VV D V + Sbjct: 141 LPEVTLGILPGARGTQLLPRVVGVPVALDLITSGKYLSADEALRLGILDAVVKSDPV-EE 199 Query: 223 ARSVMAKWFTIP 234 A K P Sbjct: 200 AIKFAQKIIDKP 211 >4IZC-A nrPDB Length = 275 Score = 161 bits (407), Expect = 3e-40, Method: Composition-based stats. Identities = 48/247 (19%), Positives = 93/247 (37%), Gaps = 8/247 (3%) Query: 40 GEAGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLM 98 + G+ V+ P N+L + + E V + K +R V+LT F AGLDL+ Sbjct: 17 RDNGVCVVTLNRPDKRNALDVATIEELVTFFSTA-HRKGVRAVVLTGAGDH-FCAGLDLV 74 Query: 99 EMYGRNP--AHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADN 156 E + + + E + ++ + +I+A+ GA GG +A R+M + Sbjct: 75 EHWKADRSADDFMHVCLRWHEAFNKMEYGGVPIIAALRGAVVGGGLALASAAHLRVMDQS 134 Query: 157 SKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPE 216 + + L E GI + IG + G ++ EA +GL + + E Sbjct: 135 TYF--ALPEGQRGIFTGGGATIRVSDMIGKYRMIDMILTGRVYQGQEAADLGLA-QYITE 191 Query: 217 DQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQKS 276 KA + K + + S + + + A+ ++ + ++ Sbjct: 192 GSSFDKAMELADKIASNLPLTNFAICSAISHMQNMSGLDAAYAEAFVGGIVNTQPAARER 251 Query: 277 LHVYLEK 283 L + K Sbjct: 252 LEAFANK 258 >3T8B-A nrPDB Length = 334 Score = 160 bits (406), Expect = 4e-40, Method: Composition-based stats. Identities = 42/281 (14%), Positives = 95/281 (33%), Gaps = 24/281 (8%) Query: 23 VDGARRFSNKRVLVEKEGEAGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGV 81 VDG + + + + + F P V N+ + E L+ + V Sbjct: 48 VDGFDDLT--DITYHRHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVV 105 Query: 82 ILTSERPG------IFSAGLDLM-------EMYGRNPAHYAEYWKA----VQELWLRLYL 124 +LT P F +G D + + A + +A + E+ + Sbjct: 106 LLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRF 165 Query: 125 SNLTLISAINGASPAGGCLMALTCDYRIMADN-SKYTIGLNESLLGIVAPFWLKDNYVNT 183 +I +NG + GG + + CD + + +++ ++ +G + Sbjct: 166 MPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFK--QTDADVGSFDGGYGSAYLARQ 223 Query: 184 IGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKS 243 +G + A LG + + ++G V+ V ++ + A+ ++++ K Sbjct: 224 VGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKF 283 Query: 244 MMRKATADNLIKQREADIQNFTSFISRDSIQKSLHVYLEKL 284 D L+ Q+ + D + +L+K Sbjct: 284 AFN-LLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKR 323 >4FZW-C nrPDB Length = 274 Score = 160 bits (404), Expect = 8e-40, Method: Composition-based stats. Identities = 53/251 (21%), Positives = 97/251 (38%), Gaps = 8/251 (3%) Query: 39 EGEAGIAVMKFKNPP-VNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDL 97 E G+ + P +NS + E + L+++E D +IR ++LT F AG DL Sbjct: 20 HVEKGVMTLTLNRPERLNSFNDEMHAQLAECLKQVERDDTIRCLLLTGAG-RGFCAGQDL 78 Query: 98 MEMYGRNPAHYAEYWKAVQE----LWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIM 153 + + +V+ L RL +I A+NG + G +AL D I Sbjct: 79 NDRNVDPTGPAPDLGMSVERFYNPLVRRLAKLPKPVICAVNGVAAGAGATLALGGDIVIA 138 Query: 154 ADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEV 213 A ++K+ + + LG++ G A LG +A + G++ +V Sbjct: 139 ARSAKFVMAFS--KLGLIPDCGGTWLLPRVAGRARAMGLALLGNQLSAEQAHEWGMIWQV 196 Query: 214 VPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSI 273 V ++ + A+ + T P L K + A + L Q + + Sbjct: 197 VDDETLADTAQQLARHLATQPTFGLGLIKQAINSAETNTLDTQLDLERDYQRLAGRSADY 256 Query: 274 QKSLHVYLEKL 284 ++ + +L K Sbjct: 257 REGVSAFLAKR 267 >3HE2-A nrPDB Length = 264 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 52/264 (19%), Positives = 100/264 (37%), Gaps = 22/264 (8%) Query: 25 GARRFSNKRVLVEKEGEAGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVIL 83 G + + ++ + P N+L+ + + E ++ K D S R ++L Sbjct: 18 GPGSM------IGITQAEAVLTIELQRPERRNALNSQLVEELTQAIRKA-GDGSARAIVL 70 Query: 84 TSERPGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCL 143 T + F AG DL A A+Y + EL + S + ++ AING + G Sbjct: 71 TGQG-TAFCAGADL-----SGDAFAADYPDRLIELHKAMDASPMPVVGAINGPAIGAGLQ 124 Query: 144 MALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAE 203 +A+ CD R++A ++ + S G+ W + +GH A L Sbjct: 125 LAMQCDLRVVAPDAFFQF--PTSKYGLALDNWSIRRLSSLVGHGRARAMLLSAEKLTAEI 182 Query: 204 ALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQN 263 AL G+ + + A++ A+ + + Q K ++ A + + A + Sbjct: 183 ALHTGMANRIGTLAD----AQAWAAEIARLAPLAIQHAKRVLNDDGA--IEEAWPAHKEL 236 Query: 264 FTSFISRDSIQKSLHVYLEKLKQK 287 F + ++ +EK K Sbjct: 237 FDKAWGSQDVIEAQVARMEKRPPK 260 >4ZU2-A nrPDB Length = 272 Score = 158 bits (399), Expect = 3e-39, Method: Composition-based stats. Identities = 56/248 (22%), Positives = 103/248 (41%), Gaps = 9/248 (3%) Query: 43 GIAVMKFKNPP-VNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMY 101 G+ + P N++SL + E L + +D+S+R ++L G F AG D+ +M Sbjct: 16 GVLRITLNRPQSRNAMSLAMVGELRAVLAAVRDDRSVRALVLRGA-DGHFCAGGDIKDMA 74 Query: 102 GRNPAH---YAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSK 158 G A Y +A L + L++ + GA GG +A D I A +++ Sbjct: 75 GARAAGAEAYRTLNRAFGSLLEEAQAAPQLLVALVEGAVLGGGFGLACVSDVAIAAADAQ 134 Query: 159 YTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPE-D 217 + GL E+ LGI+ + V IG A R F EAL++GLV + D Sbjct: 135 F--GLPETSLGILP-AQIAPFVVRRIGLTQARRLALTAARFDGREALRLGLVHFCEADAD 191 Query: 218 QVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQKSL 277 + + + + ++ TK+++ + + L + + F + + Sbjct: 192 ALEQRLEETLEQLRRCAPNANAATKALLLASESGELGALLDDAARQFAEAVGGAEGSEGT 251 Query: 278 HVYLEKLK 285 +++K K Sbjct: 252 LAFVQKRK 259 >3HIN-A nrPDB Length = 275 Score = 154 bits (390), Expect = 3e-38, Method: Composition-based stats. Identities = 42/245 (17%), Positives = 82/245 (33%), Gaps = 6/245 (2%) Query: 44 IAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYG 102 + + P N+L+ + L + IR V++ FSAGLDL E+ Sbjct: 26 VLTIGLNRPKKRNALNDGLMAALKDCLTDIP--DQIRAVVIHGIGDH-FSAGLDLSELRE 82 Query: 103 RNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTIG 162 R+ + + ++ ++ + +I+A+ GA GG +A R+ ++ Y Sbjct: 83 RDATEGLVHSQTWHRVFDKIQYCRVPVIAALKGAVIGGGLELACAAHIRVAEASAYY--A 140 Query: 163 LNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVHSK 222 L E GI IG + G ++ AE + G ++ + K Sbjct: 141 LPEGSRGIFVGGGGSVRLPRLIGVARMADMMLTGRVYSAAEGVVHGFSQYLIENGSAYDK 200 Query: 223 ARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQKSLHVYLE 282 A + + + + N + T S + + +L+ Sbjct: 201 ALELGNRVAQNAPLTNFAVLQALPMIAEANPQTGLLMESLMATVAQSDQEAKTRIRAFLD 260 Query: 283 KLKQK 287 K Sbjct: 261 HKTAK 265 >4JFC-A nrPDB Length = 281 Score = 152 bits (383), Expect = 2e-37, Method: Composition-based stats. Identities = 47/243 (19%), Positives = 100/243 (41%), Gaps = 7/243 (2%) Query: 46 VMKFKNPP-VNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRN 104 ++ NP N+L E + +L EN+ IR V++T E +F AG +L + Sbjct: 37 ILTLSNPEFRNALGPEIYAAGIEALNAAENNPEIRSVVITGEG-AVFCAGGNLQRLQANR 95 Query: 105 ---PAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTI 161 P A+ + + + +I+A+ GA+ G +AL CD+ + A N+ + + Sbjct: 96 REAPEVQAQSIEGLHNWIDSIRTYPKPVIAAVEGAAAGAGFSLALACDFVVAASNAVFVM 155 Query: 162 GLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVHS 221 + +G+ + ++ A L G +GLV++V S Sbjct: 156 SYS--TVGLSPDGGGSWSLARSLPRALASELLMGGERISAQRLHDLGLVNKVASAGDALS 213 Query: 222 KARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQKSLHVYL 281 +A + + ++ K ++ +A+++ L +Q + +F + + + + +L Sbjct: 214 EALRMAGQLNARAPNALASIKELINEASSNTLSQQLACERDHFVRNLHHSNGGEGIAAFL 273 Query: 282 EKL 284 K Sbjct: 274 GKR 276 >4JSB-A nrPDB Length = 296 Score = 145 bits (367), Expect = 1e-35, Method: Composition-based stats. Identities = 54/245 (22%), Positives = 109/245 (44%), Gaps = 23/245 (9%) Query: 44 IAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEM-- 100 +A + P N+++ TE L +++R V++T E P FS+G+DL Sbjct: 46 VARITLSRPHRRNAMTGRMWTELARIGHTLP--QAVRIVVITGEGP-TFSSGIDLDMFQA 102 Query: 101 ------------YGRNPAHYAEYWKAV---QELWLRLYLSNLTLISAINGASPAGGCLMA 145 R+P A + + QE +L L +++ I+A+ G + G +A Sbjct: 103 GKVDGEPTPFTLLARDPNSTAALDQVIASYQEGFLWLRRADIVSIAAVRGHAIGAGFQLA 162 Query: 146 LTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEAL 205 L+CD RI++D ++ + + E LG+V V +G A AEA Sbjct: 163 LSCDIRILSDTAQ--LCMKEPALGLVPDLTGTQPLVELVGVNRAIELCLTARTIDAAEAA 220 Query: 206 KVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFT 265 ++ L + VV + ++ + +++A+ +P + + TK ++ +A ++L Q + Sbjct: 221 QLRLAERVVADAELDAAVDALVAQLLAVPAAAARATKELLLQAGRNDLATQARVERTAQL 280 Query: 266 SFISR 270 + ++ Sbjct: 281 ARLAE 285 >4HDT-A nrPDB Length = 353 Score = 144 bits (364), Expect = 3e-35, Method: Composition-based stats. Identities = 57/257 (22%), Positives = 100/257 (38%), Gaps = 14/257 (5%) Query: 31 NKRVLVEKEGEAGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPG 89 N+ VLV EG G+ ++ P +NSL+ +T L END S+R V+LT Sbjct: 8 NEDVLVNVEG--GVGLLTLNRPKAINSLTHGMVTTMAERLAAWENDDSVRAVLLTGAGER 65 Query: 90 IFSAGLDLMEMYGRNPAHYAE---YWKAVQELWLRLYLSNLTLISAINGASPAGGCLMAL 146 AG D++ +Y A AE +W L + +S ++G GG + Sbjct: 66 GLCAGGDVVAIYHSAKADGAEARRFWFDEYRLNAHIGRYPKPYVSIMDGIVMGGGVGVGA 125 Query: 147 TCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALK 206 + R++ D +K + + E +G + G A G F A+A+ Sbjct: 126 HGNVRVVTDTTK--MAMPEVGIGFIPDVGGTYLLSRAPGK-LGLHAALTGAPFSGADAIV 182 Query: 207 VGLVDEVVPEDQVHSKARSVMAK--WFTIPDHSRQLTKSMMRKATADNLIKQREADIQ-- 262 +G D VP D++ R+V+A + H+++ S + + + D Sbjct: 183 MGFADHYVPHDKIDEFTRAVIADGVDAALAAHAQEPPASPL-AEQRSWIDECYTGDTVAD 241 Query: 263 NFTSFISRDSIQKSLHV 279 + + D+ Sbjct: 242 IIAALRAHDAPAAGEAA 258 >3HP0-A nrPDB Length = 267 Score = 144 bits (362), Expect = 6e-35, Method: Composition-based stats. Identities = 43/190 (22%), Positives = 74/190 (38%), Gaps = 12/190 (6%) Query: 35 LVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAG 94 ++ +A + + F P N+ + L E + + + + S V++ P +F G Sbjct: 8 TIKVRFQASVCYITFHRPEANNTINDTLIEECLQVLN-QCETSTVTVVVLEGLPEVFCFG 66 Query: 95 LDLMEMY-----GRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCD 149 D E+Y GR A E + +LW++L IS + G AGG D Sbjct: 67 ADFQEIYQEMKRGRKQASSQEP---LYDLWMKLQTGPYVTISHVRGKVNAGGLGFVSATD 123 Query: 150 YRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGL 209 I + ++ L+E L G+ + + IG + A + EA + GL Sbjct: 124 IAIADQTASFS--LSELLFGLYP-ACVLPFLIRRIGRQKAHYMTLMTKPISVQEASEWGL 180 Query: 210 VDEVVPEDQV 219 +D E V Sbjct: 181 IDAFDAESDV 190 >2A81-A nrPDB Length = 250 Score = 142 bits (357), Expect = 2e-34, Method: Composition-based stats. Identities = 51/242 (21%), Positives = 88/242 (36%), Gaps = 5/242 (2%) Query: 35 LVEKEGEAGIAVMKFKNPPV-NSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSA 93 +V +E + V+ +P N S T +L + D S+R V++ FSA Sbjct: 1 MVFEENSDEVRVITLDHPNKHNPFSRTLETSVKDALARANADDSVRAVVVYGGAERSFSA 60 Query: 94 GLDLMEMYGRNPAHYAEYW-KAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRI 152 G D E+ + + E W V +L+ + N I+A++G + G AL D R+ Sbjct: 61 GGDFNEVKQLSRSEDIEEWIDRVIDLYQAVLNVNKPTIAAVDGYAIGMGFQFALMFDQRL 120 Query: 153 MADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDE 212 MA + + + E GI T G + + + LV++ Sbjct: 121 MASTANFV--MPELKHGIGCSVGAAI-LGFTHGFSTMQEIIYQCQSLDAPRCVDYRLVNQ 177 Query: 213 VVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDS 272 VV + A + + P + TK + K L + R+A + Sbjct: 178 VVESSALLDAAITQAHVMASYPASAFINTKRAVNKPFIHLLEQTRDASKAVHKAAFQARD 237 Query: 273 IQ 274 Q Sbjct: 238 AQ 239 >5KJP-A nrPDB Length = 265 Score = 141 bits (355), Expect = 4e-34, Method: Composition-based stats. Identities = 47/253 (18%), Positives = 91/253 (35%), Gaps = 9/253 (3%) Query: 36 VEKEGEAGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAG 94 V E I ++ P N+++ ++++L+ D + ILT G F AG Sbjct: 17 VLVEQRDRILIITINRPKAKNAVNAAVSRGLADAMDQLDGDAGLSVAILTGGG-GSFCAG 75 Query: 95 LDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMA 154 +DL E LI+A+ G + AGG +AL D + A Sbjct: 76 MDLKAFARGENVVVEGRGLGFTE-----RPPTKPLIAAVEGYALAGGTELALAADLIVAA 130 Query: 155 DNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVV 214 +S + G+ E G+VA I + A G P A ++GLV+ + Sbjct: 131 RDSAF--GIPEVKRGLVAGGGGLLRLPERIPYAIAMELALTGDNLPAERAHELGLVNVLA 188 Query: 215 PEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQ 274 A ++ K + TK ++ ++ + ++ + + + Sbjct: 189 EPGTALDAAIALAEKITANGPLAVVATKRIITESRGWSPDTMFAEQMKILVPVFTSNDAK 248 Query: 275 KSLHVYLEKLKQK 287 + + E+ + + Sbjct: 249 EGAIAFAERRRPR 261 >4B3J-A nrPDB Length = 736 Score = 141 bits (355), Expect = 4e-34, Method: Composition-based stats. Identities = 57/221 (25%), Positives = 103/221 (46%), Gaps = 11/221 (4%) Query: 26 ARRFSNKRVLVEKEGEAGIAVMKFKNPP--VNSLSLEFLTEFVISLEKLEND-KSIRGVI 82 + + +K+ GI + +P N ++ ++ ++++L + SI GV+ Sbjct: 14 PNSMPDNTIQWDKDA-DGIVTLTMDDPSGSTNVMNEAYIESMGKAVDRLVAEKDSITGVV 72 Query: 83 LTSERPGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSN---LTLISAINGASPA 139 + S + F AG D+ M P + + V+ + +L +++AINGA+ Sbjct: 73 VASAKKTFF-AGGDVKTMIQARPEDAGDVFNTVETIKRQLRTLETLGKPVVAAINGAALG 131 Query: 140 GGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAA-ERALQLGTL 198 GG +AL C +RI AD +GL E LG++ V G + A L GT Sbjct: 132 GGLEIALACHHRIAADVKGSQLGLPEVTLGLLPGGGGVTRTVRMFGIQNAFVSVLAQGTR 191 Query: 199 FPPAEALKVGLVDEVVP-EDQVHSKARS-VMAKWFTIPDHS 237 F PA+A ++GLVDE+V +++ A++ + + PD + Sbjct: 192 FKPAKAKEIGLVDELVATVEELVPAAKAWIKEELKANPDGA 232 >3BPT-A nrPDB Length = 363 Score = 137 bits (345), Expect = 5e-33, Method: Composition-based stats. Identities = 32/192 (16%), Positives = 70/192 (36%), Gaps = 9/192 (4%) Query: 32 KRVLVEKEGEAGIAVMKFKNPP-VNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGI 90 + VL+ K+G G+ + P +N+L+L + + L+K E D +I+ Sbjct: 6 EEVLLGKKGCTGV--ITLNRPKFLNALTLNMIRQIYPQLKKWEQDPETFLIIIKGAGGKA 63 Query: 91 FSAGLDLM---EMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALT 147 F AG D+ E +++ L + ++ I+G + GG +++ Sbjct: 64 FCAGGDIRVISEAEKAKQKIAPVFFREEYMLNNAVGSCQKPYVALIHGITMGGGVGLSVH 123 Query: 148 CDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKV 207 +R+ + K + E+ +G+ G G + + Sbjct: 124 GQFRVATE--KCLFAMPETAIGLFPDVGGGYFLPRLQGK-LGYFLALTGFRLKGRDVYRA 180 Query: 208 GLVDEVVPEDQV 219 G+ V +++ Sbjct: 181 GIATHFVDSEKL 192 Score = 29.6 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 7/66 (10%), Positives = 22/66 (33%) Query: 221 SKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFTSFISRDSIQKSLHVY 280 S A + + S ++T + + ++ L + + + + + + + Sbjct: 260 SFALEQLKVINKMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAV 319 Query: 281 LEKLKQ 286 L Q Sbjct: 320 LIDKDQ 325 >3LAO-A nrPDB Length = 258 Score = 131 bits (329), Expect = 4e-31, Method: Composition-based stats. Identities = 45/262 (17%), Positives = 94/262 (35%), Gaps = 12/262 (4%) Query: 22 AVDGARRFSNKRVLVEKEGEAGIAVMKFKNP-PVNSLSLEFLTEFVISLEKLENDKSIRG 80 A G R + +E + ++ N+ L + +++ + E + R Sbjct: 7 ANSGPGRVT-------REQRGHLFLIGLDRAGKRNAFDSAMLADLALAMGEYERSEESRC 59 Query: 81 VILTSERPGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLY-LSNLTLISAINGASPA 139 +L + F+AGLDLME+ + A Y + W + + L+ A+ G Sbjct: 60 AVLFAHGEH-FTAGLDLMELAPKLAASGFRYPDGGVDPWGVVQPRRSKPLVVAVQGTCWT 118 Query: 140 GGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLF 199 G + L D + A +++ E L GI + G A R + G F Sbjct: 119 AGIELMLNADIAVAARGTRF--AHLEVLRGIPPLGGSTVRFPRAAGWTDAMRYILTGDEF 176 Query: 200 PPAEALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREA 259 EAL++ L+ EVV + ++A + + + + + Sbjct: 177 DADEALRMRLLTEVVEPGEELARALEYAERIARAAPLAVRAALQSAFQGRDEGDDAALSR 236 Query: 260 DIQNFTSFISRDSIQKSLHVYL 281 ++ + I + +++ + + Sbjct: 237 VNESLAALIGSEDVREGVLAMV 258 >5MRE-88 nrPDB Length = 457 Score = 122 bits (305), Expect = 3e-28, Method: Composition-based stats. Identities = 34/194 (17%), Positives = 75/194 (38%), Gaps = 13/194 (6%) Query: 46 VMKFKNPP-VNSLSLEFLTEFVISLEKLENDKSIRGVIL-TSERPGIFSAGLDLMEMY-- 101 V+ P +N+L+ E +L + + VIL +S RP F AG D+ + Sbjct: 14 VITLNRPKKLNALNAEMSESMFKTLNEYAKSDTTNLVILKSSNRPRSFCAGGDVATVAIF 73 Query: 102 --GRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKY 159 + A +++ L ++ +++ ++G + GG +++ +RI +N+K+ Sbjct: 74 NFNKEFAKSIKFFTDEYSLNFQIATYLKPIVTFMDGITMGGGVGLSIHTPFRIATENTKW 133 Query: 160 TIGLNESLLGIVAPFWLKDNYVNTIGH-----RAAERALQLGTLFPPAEALKVGLVDEVV 214 + E +G + + A G + A+A +GL V Sbjct: 134 --AMPEMDIGFFPDVGSTFALPRIVTLANSNSQMALYLCLTGEVVTGADAYMLGLASHYV 191 Query: 215 PEDQVHSKARSVMA 228 + + + + + Sbjct: 192 SSENLDALQKRLGE 205 >4Q1J-A nrPDB Length = 268 Score = 114 bits (285), Expect = 5e-26, Method: Composition-based stats. Identities = 47/251 (18%), Positives = 87/251 (34%), Gaps = 10/251 (3%) Query: 25 GARRFSNKRVLVEKEGEAGIAVMKF-KNPPVNSLSLEFLTEFVISLEKLENDKSIRGVIL 83 G S ++ E E+ I +K N+ S E + + + E + + + VIL Sbjct: 18 GPMTHSVVELI---EIESAIIQVKMQDRTHKNAFSQELTDDLIQAFEYIRQNPKYKAVIL 74 Query: 84 TSERPGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCL 143 T F++G + + L L + +I+A+ G GG + Sbjct: 75 TGY-DNYFASGGTQEGLLRIQQGLTKFTDDNLYSLALD---CEIPVIAAMQGHGIGGGFV 130 Query: 144 MALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAE 203 M L D I++ S YT G +G A+ L + A+ Sbjct: 131 MGLFADIVILSRESVYTANF--MKYGFTPGMGATFIVPKKLGFSLAQEILLNAGSYRGAD 188 Query: 204 ALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQN 263 K G+ +V+P +V A + + P +S K + D L + E ++ Sbjct: 189 LEKRGVPFKVLPRAEVLDYAVELAQELAEKPRNSLVTLKDHLVAPLRDQLPRVIEQELMM 248 Query: 264 FTSFISRDSIQ 274 + ++ Sbjct: 249 AEKTFHHEEVK 259 >2NP9-A nrPDB Length = 440 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 37/242 (15%), Positives = 83/242 (34%), Gaps = 31/242 (12%) Query: 36 VEKEGEAGIAVMKFKNPP-VNSLSLEFLTEFVISLEKLENDKSIRGVILTSE-------- 86 V E G+A + +N+ + + + +++ D +R +L Sbjct: 169 VHLERRDGVARLTMCRDDRLNAEDGQQVDDMETAVDLALLDPGVRVGLLRGGVMSHPRYR 228 Query: 87 RPGIFSAGLDLMEMYGRNPAHYAEYWKA----VQEL------------WLRLYLSNLTLI 130 +FSAG++L + + + + +L W + Sbjct: 229 GKRVFSAGINLKYLSQGGISLVDFLMRRELGYIHKLVRGVLTNDDRPGWWHSPRIEKPWV 288 Query: 131 SAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAE 190 +A++G + GG + L D + + ++ ++ L + GI+ G R + Sbjct: 289 AAVDGFAIGGGAQLLLVFDRVLASSDAYFS--LPAAKEGIIPGAANL-RLGRFAGPRVSR 345 Query: 191 RALQLGTLFPPAEALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATA 250 + + G E LVDEVV D++ + ++ + + + M+ A Sbjct: 346 QVILEGRRIWAKEPEARLLVDEVVEPDELDA---AIERSLTRLDGDAVLANRRMLNLADE 402 Query: 251 DN 252 Sbjct: 403 SP 404 >4HC8-A nrPDB Length = 255 Score = 99.3 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 48/230 (20%), Positives = 87/230 (37%), Gaps = 4/230 (1%) Query: 36 VEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGL 95 V + IAV+ + VN+L +++ + D + +++T +FS G Sbjct: 7 VSYTRKDSIAVISMDDGKVNALGPAMQQALNAAIDNADRDD-VGALVITGNG-RVFSGGF 64 Query: 96 DLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMAD 155 DL + + + EL RL ++ A G + A G + D+R+ A Sbjct: 65 DLKILTSGEVQPAIDMLRGGFELAYRLLSYPKPVVMACTGHAIAMGAFLLSCGDHRVAAH 124 Query: 156 NSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVP 215 Y I NE +G+ P+ + + A ++A L F AL G +DE+ Sbjct: 125 A--YNIQANEVAIGMTIPYAALEIMKLRLTRSAYQQATGLAKTFFGETALAAGFIDEIAL 182 Query: 216 EDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQREADIQNFT 265 + V S+A ++ + H+ TK R + + F Sbjct: 183 PEVVVSRAEEAAREFAGLNQHAHAATKLRSRADALTAIRAGIDGIAAEFG 232 >3JU1-A nrPDB Length = 407 Score = 99.3 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 36/222 (16%), Positives = 76/222 (34%), Gaps = 14/222 (6%) Query: 25 GARRFSNKRVLVEKEGEAG---IAVMKFK-NPPVNSLSLEFLTEFVISLEKLENDKSIRG 80 A F+ + V+ + A + V+ +N+L L+ + + L + D I Sbjct: 30 AAHSFATQNVVFQTLATASGKLVGVVTLNVEKALNALDLDMVRAMTVQLNLWKKDPLIAC 89 Query: 81 VILTSERPGIFSAGLDLMEMYGRNPAHYAE-------YWKAVQELWLRLYLSNLTLISAI 133 V+L F AG D+ +Y + A + +++ L L+ ++ Sbjct: 90 VVLDGSGEKAFCAGGDVRALYHASVAAKGQVTEVAKVFFEEEYRLDYLLHTYGKPVLVWG 149 Query: 134 NGASPAGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERAL 193 +G GG + ++++ + S+ I + E +G+ G Sbjct: 150 DGIVMGGGLGLMAGASHKVVTETSR--IAMPEVTIGLYPDVGGSYFLNRMPGK-MGLFLG 206 Query: 194 QLGTLFPPAEALKVGLVDEVVPEDQVHSKARSVMAKWFTIPD 235 A+A VGL D + D ++ ++ Sbjct: 207 LTAYHMNAADACYVGLADHYLNRDDKELMFDAMATLDWSDSP 248 >3M6N-A nrPDB Length = 305 Score = 94.7 bits (234), Expect = 5e-20, Method: Composition-based stats. Identities = 43/240 (17%), Positives = 81/240 (33%), Gaps = 20/240 (8%) Query: 35 LVEKEGEAGIAVMKFK-----NPPVNSLSLEFLTEFVISLEKLENDKSIRGV----ILTS 85 ++E+ + + NP S + + L + GV ++ + Sbjct: 34 IIEEPQRD-VYWIHMHADLAINPGRACFSTRLVDDITGYQTNLGQRLNTAGVLAPHVVLA 92 Query: 86 ERPGIFSAGLDLMEM----YGRNPAHYAEYWKAVQELWLRLYLS---NLTLISAINGASP 138 +F+ G DL + A +Y + ++ I+ + G + Sbjct: 93 SDSDVFNLGGDLALFCQLIREGDRARLLDYAQRCVRGVHAFHVGLGARAHSIALVQGNAL 152 Query: 139 AGGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTL 198 GG AL+C I + +GL E L + I A++ + G L Sbjct: 153 GGGFEAALSCHTIIAEEG--VMMGLPEVLFDLFPGMGAYSFMCQRISAHLAQKIMLEGNL 210 Query: 199 FPPAEALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQRE 258 + + L +GLVD VVP Q + V+ + H+ + + TA L + Sbjct: 211 YSAEQLLGMGLVDRVVPRGQGVAAVEQVIRE-SKRTPHAWAAMQQVREMTTAVPLEEMMR 269 >4ZDC-A nrPDB Length = 300 Score = 68.1 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 34/254 (13%), Positives = 72/254 (28%), Gaps = 28/254 (11%) Query: 31 NKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGI 90 N+++ EG I + +N+L E LE + ++ + I+ S Sbjct: 28 NEKISYRIEGPFFIIHL-INPDNLNALEGEDYIYLGELLELADRNRDVYFTIIQSSG-RF 85 Query: 91 FSAGLDLMEMYGRNPAHYAEYWKAVQE-----------LWLRLYLSNLTLISAINGASPA 139 FS+G D + +Y + + + LI +NG + Sbjct: 86 FSSGADFKGIAKAQGDDTNKYPSETSKWVSNFVARNVYVTDAFIKHSKVLICCLNGPAIG 145 Query: 140 GGCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLF 199 + CD ++ Y + + LG++ + G L F Sbjct: 146 LSAALVALCDIVYSINDKVYLL-YPFANLGLITEGGTTVSLPLKFGTNTTYECLMFNKPF 204 Query: 200 PPAEALKVGLVDEVV--PEDQVHSKARSVMAKWFTIP-----DHSRQLTK-------SMM 245 + G + + P + V+ + + K Sbjct: 205 KYDIMCENGFISKNFNMPSSNAEAFNAKVLEELREKVKGLYLPSCLGMKKLLKSNHIDAF 264 Query: 246 RKATADNLIKQREA 259 KA + + + + Sbjct: 265 NKANSVEVNESLKY 278 >3BF0-A nrPDB Length = 593 Score = 36.2 bits (82), Expect = 0.015, Method: Composition-based stats. Identities = 21/206 (10%), Positives = 54/206 (26%), Gaps = 60/206 (29%) Query: 66 VISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLS 125 + D ++ ++L PG + ++ + Sbjct: 328 AAQIRDARLDPKVKAIVLRVNSPG-----------------GSVTASEVIRAELAAARAA 370 Query: 126 NLTLISAINGASPAGGCLMALTCDYRIMADNS-KYTIGLNES---------LLGIVAPFW 175 ++ ++ G + +GG ++ +Y + ++ +IG+ +G+ Sbjct: 371 GKPVVVSMGGMAASGGYWISTPANYIVANPSTLTGSIGIFGVITTVENSLDSIGVHTDGV 430 Query: 176 LKDNYV-----NTIGHRAAERA----------------------------LQLGTLFPPA 202 + A + G ++ Sbjct: 431 STSPLADVSITRALPPEAQLMMQLSIENGYKRFITLVADARHSTPEQIDKIAQGHVWTGQ 490 Query: 203 EALKVGLVDEVVPEDQVHSKARSVMA 228 +A GLVD + D +KA + Sbjct: 491 DAKANGLVDSLGDFDDAVAKAAELAK 516 >2WWR-A nrPDB Length = 330 Score = 33.1 bits (74), Expect = 0.13, Method: Composition-based stats. Identities = 11/45 (24%), Positives = 18/45 (40%) Query: 162 GLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALK 206 GL +S +GI+ + + +R L G P EA + Sbjct: 152 GLTQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGRQPRPEEAAE 196 >6FAH-B nrPDB Length = 262 Score = 31.5 bits (70), Expect = 0.48, Method: Composition-based stats. Identities = 17/122 (13%), Positives = 36/122 (29%), Gaps = 6/122 (4%) Query: 165 ESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFPPAEALKVGLVDEVVPEDQVHSKAR 224 E+ L I + V T+G A L+ EA L D + + Sbjct: 43 EAALVIKDENPGTEVIVMTMGPPQASEMLRECLAMGADEAYL--LSDRAFGGADTWATSA 100 Query: 225 SVMAKWFTIPDHSRQLTKSMMRKA----TADNLIKQREADIQNFTSFISRDSIQKSLHVY 280 ++ A + L + ++ + + + I + + +H Sbjct: 101 TLAAGIKKVKKVDLVLAGRQAIDGDTAQVGSQIAQRLKMPVVTYVEDIKIEDKKAIVHRQ 160 Query: 281 LE 282 +E Sbjct: 161 ME 162 >3FK4-A nrPDB Length = 414 Score = 30.8 bits (68), Expect = 0.73, Method: Composition-based stats. Identities = 32/187 (17%), Positives = 62/187 (33%), Gaps = 34/187 (18%) Query: 36 VEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILTSERPGIFSAGL 95 + K+ + GI +++ P +N S + + KL D ++ + LT FS Sbjct: 67 LRKKVKRGIIKIEY--PLLN-FSPDLPAILTTTFGKLSLDGEVKLIDLT------FS--- 114 Query: 96 DLMEMYGRNPAHYAEYWKAVQELWLR--LYLSNLTLISAINGA--------SPAGGCLMA 145 D ++ + P + + + ++ R L +I G + G Sbjct: 115 DELKKHFPGPKFGIDGIRNLLQVHDRPLLMSIFKGMIGRNIGYLKTQLRDQAIGG----- 169 Query: 146 LTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTLFP----P 201 D + D + L IV+ + + T GH+ G F Sbjct: 170 --VDI-VKDDEILFENALTPLTKRIVSGKEVLQSVYETYGHKTLYAVNLTGRTFDLKENA 226 Query: 202 AEALKVG 208 A++ G Sbjct: 227 KRAVQAG 233 >2JIS-A nrPDB Length = 515 Score = 30.4 bits (67), Expect = 0.85, Method: Composition-based stats. Identities = 14/44 (31%), Positives = 17/44 (38%) Query: 79 RGVILTSERPGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRL 122 R ++ S GIF G + MY N A Y Y Q L Sbjct: 158 RALVGWSSGDGIFCPGGSISNMYAVNLARYQRYPDCKQRGLRTL 201 >3DO6-A nrPDB Length = 543 Score = 30.4 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 12/55 (21%), Positives = 25/55 (45%) Query: 80 GVILTSERPGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAIN 134 V++ + R + G +L ++ N E +K ++ L NL ++ A+N Sbjct: 314 AVLVATVRALKYHGGANLKNIHEENLEALKEGFKNLRVHVENLRKFNLPVVVALN 368 >6EM4-v nrPDB Length = 231 Score = 30.0 bits (66), Expect = 1.1, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 27/68 (39%), Gaps = 4/68 (5%) Query: 55 NSLSLEFLT----EFVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRNPAHYAE 110 N + + E +++ DK+ V + + F A D+ E+ R+ E Sbjct: 98 NDYNAATVELDENEIPEGGARIQRDKNGDVVRVVYGKKKNFDADEDVNEIKARDTTEETE 157 Query: 111 YWKAVQEL 118 K ++EL Sbjct: 158 VVKKLEEL 165 >4R6L-A nrPDB Length = 519 Score = 29.6 bits (65), Expect = 1.4, Method: Composition-based stats. Identities = 22/125 (17%), Positives = 36/125 (28%), Gaps = 15/125 (12%) Query: 141 GCLMALTCDYRIMADNSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQL----G 196 G L+AL D I+A + L E G+ + + + R G Sbjct: 30 GLLLALAADMTIVAGS----DNLPELT-GLAIGALIGRSAADVFDSETHNRLTIALAEPG 84 Query: 197 TLFPPAEA------LKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATA 250 A G V DQ+ + P + T S +R+ A Sbjct: 85 AAVGAPIAVGFTMRKDAGFVGSWHRHDQLVFLELEPPQRDVAEPQAFFRRTNSAIRRLQA 144 Query: 251 DNLIK 255 ++ Sbjct: 145 AETLE 149 >6F73-A nrPDB Length = 574 Score = 29.6 bits (65), Expect = 1.5, Method: Composition-based stats. Identities = 10/50 (20%), Positives = 18/50 (36%), Gaps = 1/50 (2%) Query: 107 HYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADN 156 E + R+ + + G + GG + L+ Y + ADN Sbjct: 202 EGFEAYAMANSTGHRIVGGTCPTVGIVGGYTQGGGHSI-LSSSYGVAADN 250 >6N2Y-G nrPDB Length = 285 Score = 29.6 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 17/128 (13%), Positives = 38/128 (29%), Gaps = 24/128 (18%) Query: 25 GARRFSNKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILT 84 GA S+ ++ + G V+ + + L +++K +I+ Sbjct: 59 GAGGASHPMLVSRPVKKTGYLVITSDRGLAGAYNSNVLRLVYQTIQKRHASPDEYAIIVI 118 Query: 85 SERPGIF------------------SAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSN 126 F + D+ E+ + +A+ + LY+ Sbjct: 119 GRVGLSFFRKRNMPVILDITRLPDQPSFADIKEIARKTVGLFADG------TFDELYMYY 172 Query: 127 LTLISAIN 134 +SAI Sbjct: 173 NHYVSAIQ 180 >3N6R-B nrPDB Length = 531 Score = 28.5 bits (62), Expect = 3.7, Method: Composition-based stats. Identities = 12/70 (17%), Positives = 21/70 (30%), Gaps = 6/70 (8%) Query: 92 SAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYR 151 S G + E + + + + + + IS I G G D+ Sbjct: 149 SGGARIQEGVDSLAGYGEVFQRNI------MASGVVPQISMIMGPCAGGAVYSPAMTDFI 202 Query: 152 IMADNSKYTI 161 M +S Y Sbjct: 203 FMVKDSSYMF 212 >5N4B-A nrPDB Length = 731 Score = 28.1 bits (61), Expect = 4.1, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 30/82 (36%), Gaps = 9/82 (10%) Query: 109 AEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMADNSKYTIGLNESLL 168 ++ A Q L Y + + AINGA+ G +M + A + + E + Sbjct: 552 DDFIAAAQFLVKNKYAAPGKV--AINGAANGGLLVMGS----IVRAPEGTFGAAVPEGGV 605 Query: 169 GIVAPFW---LKDNYVNTIGHR 187 + F +++ G+ Sbjct: 606 ADLLKFHKFTGGQAWISEYGNP 627 >4IKY-A nrPDB Length = 507 Score = 28.1 bits (61), Expect = 4.2, Method: Composition-based stats. Identities = 15/100 (15%), Positives = 29/100 (29%), Gaps = 7/100 (7%) Query: 156 NSKYTIGLNESLLG-----IVAPFWLKDNYVNTIGHRAAERALQLG-TLFPPAEALKVGL 209 ++ ++I LG +V +G A + LG +F +GL Sbjct: 155 DAGFSIFYMGINLGAFLAPLVVGTAGMKY-NFHLGFGLAAVGMFLGLVVFVATRKKNLGL 213 Query: 210 VDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKAT 249 VP ++ + A L ++ Sbjct: 214 AGTYVPNPLTPAEKKKAAAIMAVGAVVIAVLLAILIPNGW 253 >4Q28-A nrPDB Length = 113 Score = 28.1 bits (61), Expect = 4.5, Method: Composition-based stats. Identities = 7/17 (41%), Positives = 9/17 (52%) Query: 195 LGTLFPPAEALKVGLVD 211 G P EA + GL+D Sbjct: 22 TGRELSPEEAHRAGLID 38 >6H7W-Q nrPDB Length = 846 Score = 28.1 bits (61), Expect = 4.5, Method: Composition-based stats. Identities = 14/96 (14%), Positives = 29/96 (30%), Gaps = 4/96 (4%) Query: 190 ERALQLGTLFPPAEALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKAT 249 + E L + ++ +V P++ + + H + Sbjct: 229 LEQIVQCRDILAQEYL-LEVITQVFPDEYHLHTLDQFLGAVSRLNPHVNV---KAIVIGM 284 Query: 250 ADNLIKQREADIQNFTSFISRDSIQKSLHVYLEKLK 285 + L E + QN +++L LEK K Sbjct: 285 MNRLSDYAERESQNEPEEDRAKLEEEALAKLLEKTK 320 >3CB4-D nrPDB Length = 599 Score = 28.1 bits (61), Expect = 4.6, Method: Composition-based stats. Identities = 11/59 (18%), Positives = 24/59 (40%), Gaps = 1/59 (1%) Query: 26 ARRFSNKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVILT 84 A VL+ E +A++ ++ N E + + + + + D +I+ I T Sbjct: 477 ASDMVRVDVLINGERVDALALITHRDNSQNR-GRELVEKMKDLIPRQQFDIAIQAAIGT 534 >2C8T-A nrPDB Length = 206 Score = 28.1 bits (61), Expect = 4.8, Method: Composition-based stats. Identities = 10/27 (37%), Positives = 15/27 (55%) Query: 197 TLFPPAEALKVGLVDEVVPEDQVHSKA 223 F AEAL+ G VD ++ V+ +A Sbjct: 174 RWFTAAEALEYGFVDHIITRAHVNGEA 200 >3IBB-A nrPDB Length = 530 Score = 27.7 bits (60), Expect = 5.7, Method: Composition-based stats. Identities = 19/153 (12%), Positives = 43/153 (28%), Gaps = 18/153 (11%) Query: 96 DLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLTLISAINGASPAGGCLMALTCDYRIMAD 155 D+ + + +L + + LI+ I + G + + Sbjct: 375 DVPGFLPGVDQEHDGIIRRGAKLIFAYAEATVPLITVITRKAFGGAYAVMGSKHL----- 429 Query: 156 NSKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERALQLGTL---------FPPAEALK 206 + + + + ++ + A + A P A + Sbjct: 430 GADLNLAWPTAQIAVMGAQGAVNILHRRTIADAGDDAEATRARLIQEYEDALLNPYTAAE 489 Query: 207 VGLVDEVV-PED---QVHSKARSVMAKWFTIPD 235 G VD V+ P D + R + K ++P Sbjct: 490 RGYVDAVIMPSDTRRHIVRGLRQLRTKRESLPP 522 >5ZF1-A nrPDB Length = 301 Score = 27.7 bits (60), Expect = 6.7, Method: Composition-based stats. Identities = 11/60 (18%), Positives = 21/60 (35%), Gaps = 5/60 (8%) Query: 24 DGARRFSNKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTEFVISLEKLENDKSIRGVIL 83 D + R VE GI + S + + ++ L D S+ G+++ Sbjct: 42 DDPASHTYVRNKVEAAKFVGIDALTINRD-----SDITEEQLLSEIQNLNEDNSVDGILV 96 >1SKF-A nrPDB Length = 262 Score = 27.3 bits (59), Expect = 8.3, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 13/35 (37%), Gaps = 3/35 (8%) Query: 126 NLTLISAINGASPAGGCLMALTCDYRIMADNSKYT 160 I+A+ G + G L Y AD + T Sbjct: 2 TKPTIAAVGGYAMNNGTGTTL---YTKAADTRRST 33 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.136 0.345 Lambda K H 0.267 0.0420 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 10,029,360 Number of Sequences: 36641 Number of extensions: 381897 Number of successful extensions: 1592 Number of sequences better than 10.0: 90 Number of HSP's better than 10.0 without gapping: 97 Number of HSP's successfully gapped in prelim test: 48 Number of HSP's that attempted gapping in prelim test: 1287 Number of HSP's gapped (non-prelim): 154 length of query: 289 length of database: 10,336,785 effective HSP length: 96 effective length of query: 193 effective length of database: 6,819,249 effective search space: 1316115057 effective search space used: 1316115057 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 59 (27.3 bits)