BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P22680 (504 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3SN5-A nrPDB 999 0.0 2IAG-A nrPDB 261 5e-70 3B98-A nrPDB 258 4e-69 5JLC-A nrPDB 105 5e-23 4WMZ-A nrPDB 100 1e-21 3JUS-A nrPDB 81 1e-15 2WX2-A nrPDB 80 2e-15 3L4D-A nrPDB 77 1e-14 5FSA-A nrPDB 74 2e-13 2W0A-A nrPDB 73 2e-13 5YLW-A nrPDB 72 4e-13 2X2N-A nrPDB 70 1e-12 2VE3-A nrPDB 68 8e-12 6CR2-A nrPDB 68 9e-12 4R1Z-A nrPDB 67 2e-11 6B82-A nrPDB 64 2e-10 3EL3-A nrPDB 63 4e-10 6M7X-A nrPDB 60 2e-09 4KPA-A nrPDB 60 3e-09 5VEU-A nrPDB 58 9e-09 6AYB-A nrPDB 57 2e-08 3K9V-A nrPDB 57 3e-08 6DA2-A nrPDB 55 7e-08 3MZS-A nrPDB 55 9e-08 4R20-A nrPDB 55 1e-07 6C94-A nrPDB 53 2e-07 3N9Z-A nrPDB 52 5e-07 3E6I-A nrPDB 51 1e-06 4ZGX-A nrPDB 50 2e-06 2NNH-A nrPDB 50 3e-06 2HI4-A nrPDB 50 3e-06 3S79-A nrPDB 49 4e-06 5UYS-A nrPDB 49 5e-06 1N6B-A nrPDB 48 1e-05 5W0C-A nrPDB 47 1e-05 3MDV-A nrPDB 47 2e-05 3DBM-A nrPDB 46 4e-05 4H1N-A nrPDB 46 5e-05 3QZ1-A nrPDB 45 7e-05 4GQS-A nrPDB 45 9e-05 5E58-A nrPDB 44 2e-04 3IBD-A nrPDB 44 2e-04 5VBU-A nrPDB 42 5e-04 5E0E-A nrPDB 40 0.002 2RCM-A nrPDB 38 0.012 6IQ5-A nrPDB 37 0.028 3NC3-A nrPDB 36 0.035 6DCD-A nrPDB 36 0.037 3DL9-A nrPDB 35 0.061 3TBG-A nrPDB 35 0.067 6DWN-A nrPDB 35 0.086 2PG7-A nrPDB 34 0.12 4PWV-A nrPDB 33 0.40 1CPT-A nrPDB 32 0.58 5L94-A nrPDB 31 1.3 1WIY-A nrPDB 31 1.4 2IJ7-A nrPDB 30 2.2 5HIW-A nrPDB 30 3.5 2RHI-A nrPDB 29 4.4 >3SN5-A nrPDB Length = 491 Score = 999 bits (2584), Expect = 0.0, Method: Compositional matrix adjust. Identities = 478/479 (99%), Positives = 478/479 (99%) Query: 25 RRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLS 84 RRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLS Sbjct: 8 RRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLS 67 Query: 85 YHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTES 144 YHKVLCHGKYFDWKKFHFA SAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTES Sbjct: 68 YHKVLCHGKYFDWKKFHFALSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTES 127 Query: 145 MMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILN 204 MMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILN Sbjct: 128 MMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILN 187 Query: 205 NLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLN 264 NLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLN Sbjct: 188 NLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLN 247 Query: 265 DTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQ 324 DTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQ Sbjct: 248 DTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQ 307 Query: 325 KVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKD 384 KVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKD Sbjct: 308 KVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKD 367 Query: 385 DIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATIC 444 DIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATIC Sbjct: 368 DIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATIC 427 Query: 445 PGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKH 503 PGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKH Sbjct: 428 PGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKH 486 >2IAG-A nrPDB Length = 482 Score = 261 bits (667), Expect = 5e-70, Method: Compositional matrix adjust. Identities = 161/487 (33%), Positives = 254/487 (52%), Gaps = 19/487 (3%) Query: 25 RRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLS 84 R R+ GEPPL+ G IP+LG AL FG + FL + KHG +FT + G+YV + +P S Sbjct: 1 RTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHS 60 Query: 85 YHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIK-TLQGHALNSLTE 143 Y V+ + + F A R D + + + +K TL L +LTE Sbjct: 61 YDAVVWEPR----TRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTE 116 Query: 144 SMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFG-----RDLTRRDTQ 198 +M NL ++ + + W G+ F Y + AGYLT++G R + Sbjct: 117 AMYTNLHAVLLG--DATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQD 174 Query: 199 KAHILNNLDNFKQFDKVFPALVAG-LPIHMFRTAHNAREKLAESLRHENLQKRESISELI 257 + H + F+Q D++ P L G L + + + +L + L L +R S+ + Sbjct: 175 RVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWL 234 Query: 258 SLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKR 317 + + + ++++ A+ ++ LWA+Q N PA FW L +++NPEA+ A E++ Sbjct: 235 ESYLLHLEEMGVSEEMQ-ARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELES 293 Query: 318 TLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDG 377 L A Q VS L Q L+ PVLDS++ ESLRL++A R D + + DG Sbjct: 294 ILWQAEQPVS---QTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADG 350 Query: 378 -SYNIRKDDIIALYPQLM-HLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYM 435 +N+R+ D + L+P L DPEIY DP FKY+R+L+ +G K FY +G +LK Y M Sbjct: 351 REFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNM 410 Query: 436 PFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDI 495 P+G+G C GR +A++ IKQF+ L+L + +LELI + P D SR G G++ P +D+ Sbjct: 411 PWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDV 470 Query: 496 EFKYKFK 502 +Y+ + Sbjct: 471 PVRYRIR 477 >3B98-A nrPDB Length = 475 Score = 258 bits (659), Expect = 4e-69, Method: Compositional matrix adjust. Identities = 155/487 (31%), Positives = 257/487 (52%), Gaps = 28/487 (5%) Query: 20 LILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFI 79 ++ G R R+ EPPL+ G+IP+LG AL+FG + +FL + KHG +FT + G Y+ + Sbjct: 8 VLYGRRTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVL 67 Query: 80 TNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALN 139 + Y VL D + + F I P +E QG +L Sbjct: 68 LDSNCYDAVLSDVASLDQTSYAQVLMKRIFN--MILPSHNPESEKKRAEM--HFQGASLT 123 Query: 140 SLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQK 199 L+ SM NL R++ P KT+ W +G+++ CY ++F+ GYLT+FG + + Sbjct: 124 QLSNSMQNNL-RLLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGYLTVFGAE----NNNS 178 Query: 200 AHILNNLDNFKQFDKVFPALV-AGLPIHMFRTAHNAREKLAESLRHENLQKR-ESISELI 257 A + + F++FDK+ P L + + A AREKL + L L ++ S L Sbjct: 179 AALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTPSGLDRKPREQSWLG 238 Query: 258 SLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKR 317 S L D D + + L+ LW +Q N PA FW + ++ +PEA++A EE++ Sbjct: 239 SYVKQLQD--EGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQ- 295 Query: 318 TLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDG 377 G+ + LE + PV DS++ E+LRL++A+L R +D + L +G Sbjct: 296 ----GGKHLRLE--------ERQKNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNG 343 Query: 378 S-YNIRKDDIIALYPQLM-HLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYM 435 Y++R+ D + ++P + +DP+I+ P F++DR+L+ + K F+ NG ++KY + Sbjct: 344 QEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPSV 403 Query: 436 PFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDI 495 P+G+ +CPGR FA+H IK+ + +L+ F++EL + A P +D SR G GIL P D+ Sbjct: 404 PWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDL 463 Query: 496 EFKYKFK 502 E +Y+ + Sbjct: 464 EIRYRIR 470 >5JLC-A nrPDB Length = 515 Score = 105 bits (262), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 115/496 (23%), Positives = 210/496 (42%), Gaps = 67/496 (13%) Query: 19 WLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHF 78 W +L R+ PPL IP++G A+ +G P EF Q+K+G +F+ L+G+ + Sbjct: 27 WQLLYSLRKD--RPPLVFYWIPWVGSAIPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTV 84 Query: 79 ITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDG--------NTTENINDTFI 130 P H+ + + K D ++ A+ H + P+ G N F+ Sbjct: 85 YLGPKG-HEFIFNAKLAD------VSAEAAYSHLTT-PVFGKGVIYDCPNHRLMEQKKFV 136 Query: 131 K-TLQGHALNSLTESMMENLQRIMRPPVSSNSK---TAAWVTEGMYSFCYRVMFEAGYLT 186 K L A + E + + R S N K + + + M S +F A + Sbjct: 137 KGALTKEAFVRYVPLIAEEIYKYFRN--SKNFKINENNSGIVDVMVSQPEMTIFTAS-RS 193 Query: 187 IFGRDLTRR-DTQKAHILNNLD-NFKQFDKVFPALVAGLPIHMFRTAHNAREKLA----- 239 + G+++ + DT A++ ++LD F + VFP LP+ +R +A++ ++ Sbjct: 194 LLGKEMRDKLDTDFAYLYSDLDKGFTPINFVFP----NLPLEHYRKRDHAQQAISGTYMS 249 Query: 240 ---ESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFW 296 E ++Q R+ I EL+ + + T T D E A + VL Q + + W Sbjct: 250 LIKERREKNDIQNRDLIDELMKNSTYKDGTKMT--DQEIANLLIGVLMGGQHTSAATSAW 307 Query: 297 SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL 356 L + P+ + +E R L N ++++ + +L ++P+L+ +IKE+LRL Sbjct: 308 CLLHLAERPDVQEELYQEQMRVLNNDTKELTYD---------DLQNMPLLNQMIKETLRL 358 Query: 357 SSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDE 415 ++ R D + + + SY + +D + + P HL E +P P F R+ Sbjct: 359 HHPLHSLFRKVMRD--VAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRW--- 413 Query: 416 NGKTKTTFYCNGLKLKYY-----------YMPFGSGATICPGRLFAIHEIKQFLILMLSY 464 +G ++ G ++ Y Y+PFG G C G LFA ++ + + + Sbjct: 414 DGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRT 473 Query: 465 FELELIEGQAKCPPLD 480 + PP D Sbjct: 474 MKWRYPTEGETVPPSD 489 >4WMZ-A nrPDB Length = 539 Score = 100 bits (250), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 112/495 (22%), Positives = 212/495 (42%), Gaps = 68/495 (13%) Query: 18 LWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVH 77 +W +L R+ PPL IP++G A+ +G P EF Q+K+G +F+ L+G+ + Sbjct: 44 VWQLLYSLRKD--RPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMT 101 Query: 78 FITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDG--------NTTENINDTF 129 P H+ + + K D ++ A+ H + P+ G N+ F Sbjct: 102 VYLGPKG-HEFVFNAKLAD------VSAEAAYAHLTT-PVFGKGVIYDCPNSRLMEQKKF 153 Query: 130 IK-TLQGHALNSLTESMMENLQRIMRPP--VSSNSKTAAWVTEGMYSFCYRVMFEAGYLT 186 +K L A S + E + + R N +T + + M + +F A + Sbjct: 154 VKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTI-DVMVTQPEMTIFTAS-RS 211 Query: 187 IFGRDL-TRRDTQKAHILNNLD-NFKQFDKVFPALVAGLPIHMFRTAHNAREKLA----- 239 + G+++ + DT A++ ++LD F + VFP LP+ +R +A++ ++ Sbjct: 212 LLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFP----NLPLEHYRKRDHAQKAISGTYMS 267 Query: 240 ---ESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFW 296 E ++ ++Q R+ I L+ + + T D E A + VL Q + + W Sbjct: 268 LIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMT--DQEIANLLIGVLMGGQHTSAATSAW 325 Query: 297 SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL 356 L + P+ + EE R L+ ++++ + L ++P+L+ IKE+LR+ Sbjct: 326 ILLHLAERPDVQQELYEEQMRVLDGGKKELTYD---------LLQEMPLLNQTIKETLRM 376 Query: 357 SSA--SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLD 414 SL + K+ +H+ + SY I + + P HL E +P+ F R+ + Sbjct: 377 HHPLHSLFRKVMKD---MHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNN 433 Query: 415 ENGKTKTTFYCNGLKLKYY-----------YMPFGSGATICPGRLFAIHEIKQFLILMLS 463 ++ + Y G ++ Y Y+PFG G C G FA ++ + + + Sbjct: 434 DSASS----YSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIR 489 Query: 464 YFELELIEGQAKCPP 478 + EG+ PP Sbjct: 490 TLKWHYPEGKTVPPP 504 >3JUS-A nrPDB Length = 461 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 111/461 (24%), Positives = 190/461 (41%), Gaps = 64/461 (13%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGK-YVHFITNPLSYHKVLC 90 PP IP+LG A+ FG +P+EFL K+G VF+ ++GK + + + + + Sbjct: 13 PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNS 72 Query: 91 HGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFI--KTLQGHALNSLTESMMEN 148 + + + + + FG G + N F+ K + LN + Sbjct: 73 KNEDLNAEDVYSRLTTPVFGK-------GVAYDVPNPVFLEQKKMLKSGLN-----IAHF 120 Query: 149 LQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLT----IFGRDLTRRDTQK-AHIL 203 Q + + +W G + + + E LT + G+++ + +K A + Sbjct: 121 KQHVSIIEKETKEYFESWGESGEKN-VFEALSELIILTASHCLHGKEIRSQLNEKVAQLY 179 Query: 204 NNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELIS--LRM 261 +LD F L LP+ FR A ++ + + ++ +QKR E I L+ Sbjct: 180 ADLDG--GFSHAAWLLPGWLPLPSFRRRDRAHREIKD-IFYKAIQKRRQSQEKIDDILQT 236 Query: 262 FLNDTLST---FDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRT 318 L+ T D E A + +L A Q + + W F + R+ +T Sbjct: 237 LLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARD------------KT 284 Query: 319 LENAGQKVSLEGNPIC------LSQAELNDLPVLDSIIKESLRLSSA-SLNIRTAKEDFT 371 L+ +K LE +C L+ +L DL +LD IKE+LRL + +R A+ T Sbjct: 285 LQ---KKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQT 341 Query: 372 LHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLK 431 + Y I + + P + + + + L F DRYL +N + K Sbjct: 342 V----AGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGE---------K 388 Query: 432 YYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEG 472 + Y+PFG+G C G FA +IK ML +E +LI+G Sbjct: 389 FAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG 429 >2WX2-A nrPDB Length = 473 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 108/494 (21%), Positives = 199/494 (40%), Gaps = 70/494 (14%) Query: 31 EPPLENGLIPYLGCALQFGANPLEFLRANQR--KHGHVFTCKLMGKYVHFITNPLSYHKV 88 +PP+ +P+LG +QFG NPLEF++ +R K G VFT + G+ V + +P + + Sbjct: 17 DPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSG-VFTISIGGQRVTIVGDPHEHSRF 75 Query: 89 LCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESM--- 145 + + FG E + LN L E + Sbjct: 76 FSPRNEILSPREVYTIMTPVFG------------EGVAYAAPYPRMREQLNFLAEELTIA 123 Query: 146 -----MENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQK- 199 + +Q +R ++ N K V + C ++ +FG DL +R + Sbjct: 124 KFQNFVPAIQHEVRKFMAENWKEDEGVI-NLLEDCGAMIINTACQCLFGEDLRKRLNARH 182 Query: 200 -AHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESL-------RHENLQKRE 251 A +L+ +++ VF + LP+ AR +L + L E K Sbjct: 183 FAQLLSKMESSLIPAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDN 242 Query: 252 SISELIS--LRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMK 309 + S+L+ L+ D + E + ++A Q + T WS+ ++ +P+ K Sbjct: 243 NTSDLLGGLLKAVYRDG-TRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLM-HPKN-K 299 Query: 310 AATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKE 368 +++ + ++ +++ + ++++P + ++ES+R L + R K Sbjct: 300 KWLDKLHKEIDEFPAQLNYDNV--------MDEMPFAERCVRESIRRDPPLLMVMRMVKA 351 Query: 369 DFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGL 428 + + GSY + K DIIA P L H D E +P+P + +R DE Sbjct: 352 EVKV----GSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPER--DE------------- 392 Query: 429 KLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGI 488 K+ ++ FG+G C G+ FA+ ++K L ++ +L+ + P G Sbjct: 393 KVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVG--- 449 Query: 489 LPPLNDIEFKYKFK 502 P LN KY K Sbjct: 450 -PTLNQCLVKYTRK 462 >3L4D-A nrPDB Length = 453 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 103/465 (22%), Positives = 183/465 (39%), Gaps = 74/465 (15%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCH 91 PP+ +G P++G +QFG +PL F+ ++K+G +FT + G + + + V H Sbjct: 5 PPVVHGTTPFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITVVGD------VHQH 58 Query: 92 GKYFDWKK--------FHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTE 143 K+F + + F G P E +N + L + Sbjct: 59 SKFFTPRNEILSPREVYSFMVPVFGEGVAYAAPYP-RMREQLN-FLAEELTVAKFQNFAP 116 Query: 144 SMMENLQRIMRPPVSSNSKTAAW-VTEGMYSF---CYRVMFEAGYLTIFGRDLTRR--DT 197 S+ +++ M+ A W EG + C ++ +FG DL +R Sbjct: 117 SIQHEVRKFMK---------ANWNKDEGEINILDDCSAMIINTACQCLFGEDLRKRLDAR 167 Query: 198 QKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESL-------RHENLQKR 250 Q A +L +++ VF + LP+ +AR +L + L E QK Sbjct: 168 QFAQLLAKMESCLIPAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKD 227 Query: 251 ESISELIS--LRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMI--RNPE 306 + S+L++ L D + E + ++A Q + T WSL ++ RN Sbjct: 228 TNTSDLLAGLLGAVYRDG-TRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRN-- 284 Query: 307 AMKAATEEVKRTLENAGQKVSLEGNPICLSQAE-LNDLPVLDSIIKESLRLSSASLNIRT 365 KR L Q++ + P L+ + ++P + +ES+R + + Sbjct: 285 ---------KRHLAKLHQEI--DEFPAQLNYDNVMEEMPFAEQCARESIRRDPPLVML-- 331 Query: 366 AKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYC 425 ++ G Y + + DIIA P L H D E +P+P + +R N K +C Sbjct: 332 -MRKVLKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPER----NMKLVDGAFC 386 Query: 426 NGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELI 470 FG+G C G F + ++K L +L ++ EL+ Sbjct: 387 G----------FGAGVHKCIGEKFGLLQVKTVLATVLRDYDFELL 421 >5FSA-A nrPDB Length = 490 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 107/488 (21%), Positives = 195/488 (39%), Gaps = 52/488 (10%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCH 91 PPL IP+ G A +G P EF + ++K+G VF+ L+GK + P H+ + + Sbjct: 6 PPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKG-HEFVFN 64 Query: 92 GKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENL-- 149 K D ++ +A+ H + + ++ + + A +LT + Sbjct: 65 AKLSD------VSAEEAYKHLTTPVFGTGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVP 118 Query: 150 ---QRIMRPPVSSNSKTAAWVTEGMYSFCY---RVMFEAGYLTIFGRDLTR-RDTQKAHI 202 + I+ V+ S T G+ + + ++FG ++ R D A + Sbjct: 119 KIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQL 178 Query: 203 LNNLD-NFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRM 261 ++LD F + VFP L LP + R A A++K++ + E +RE ++ R Sbjct: 179 YSDLDKGFTPINFVFPNL--PLPHYWRRDA--AQKKISATYMKEIKLRRER-GDIDPNRD 233 Query: 262 FLNDTL--STFD------DLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATE 313 ++ L ST+ D E A + +L Q + + W L + P + Sbjct: 234 LIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQ 293 Query: 314 EVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLH 373 EV L+ G G+ L+ +L LP +++ IKE+LR+ L+ K L Sbjct: 294 EVVELLKEKG------GDLNDLTYEDLQKLPSVNNTIKETLRM-HMPLHSIFRKVTNPLR 346 Query: 374 LEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYY 433 + + +Y + K + + P H + +P F R+ K + + + ++ Y Sbjct: 347 IPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYG 406 Query: 434 -----------YMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQS 482 Y+PFG G C G FA ++ L + + L K P D Sbjct: 407 FGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV--YNLRWTIDGYKVP--DPD 462 Query: 483 RAGLGILP 490 + + +LP Sbjct: 463 YSSMVVLP 470 >2W0A-A nrPDB Length = 455 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 65/258 (25%), Positives = 117/258 (45%), Gaps = 31/258 (12%) Query: 223 LPIHMFRTAHNAREKLAESL------RHENLQKRESISELISLRMFLNDTLST--FDDLE 274 LPI FR AR L + R N +S +++ + + + T F E Sbjct: 186 LPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADE 245 Query: 275 KAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPIC 334 + +++A + W+L +++R+ +A A +E+ L G+ VS Sbjct: 246 ITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDE-LYGDGRSVSFHA---- 300 Query: 335 LSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQL 393 L +P L++++KE+LRL + + R AK +F + + I + D++A P + Sbjct: 301 -----LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQ----GHRIHEGDLVAASPAI 351 Query: 394 MHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHE 453 + PE +PDP F RY E + + L ++ ++PFG+G C G FAI + Sbjct: 352 SNRIPEDFPDPHDFVPARY--EQPRQED------LLNRWTWIPFGAGRHRCVGAAFAIMQ 403 Query: 454 IKQFLILMLSYFELELIE 471 IK ++L +E E+ + Sbjct: 404 IKAIFSVLLREYEFEMAQ 421 >5YLW-A nrPDB Length = 495 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 107/459 (23%), Positives = 182/459 (39%), Gaps = 73/459 (15%) Query: 22 LGIRRRQTGEPPLENGLIPY--LGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFI 79 L RRR+ P G PY +G LQ GANP + +++G + + L Y + Sbjct: 20 LSFRRRRNLPP----GPFPYPIVGNMLQLGANPHQVFAKLSKRYGPLMSIHLGSLYTVIV 75 Query: 80 TNPLSYHKVLC-HGKYFDWKKFHFATSAKAFGHRSID----PMDGN--------TTENIN 126 ++P ++L HG+ F + A + A H I P+ + + Sbjct: 76 SSPEMAKEILHRHGQVFSGRTI--AQAVHACDHDKISMGFLPVASEWRDMRKICKEQMFS 133 Query: 127 DTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLT 186 + ++ QG L + +++++Q+ S+S A + E + +M T Sbjct: 134 NQSMEASQGLRRQKL-QQLLDHVQK------CSDSGRAVDIREAAFITTLNLM----SAT 182 Query: 187 IFGRDLTRRDTQKA-------HILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKL- 238 +F T D++ + + F FP L P + R A KL Sbjct: 183 LFSSQATEFDSKATMEFKEIIEGVATIVGVPNFADYFPILRPFDPQGVKRRADVFFGKLL 242 Query: 239 --AESLRHENLQKRESISELISLRMFLNDTLSTFDDLE-KAKTH-----LVVLWASQANT 290 E +E L+ + + FL + E K KTH ++ L+ ++T Sbjct: 243 AKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFKLKTHHFTHLMLDLFVGGSDT 302 Query: 291 IPATF-WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSI 349 + W++ +++ NP+ M E+K S+ G+ + ++ + LP L ++ Sbjct: 303 NTTSIEWAMSELVMNPDKMARLKAELK----------SVAGDEKIVDESAMPKLPYLQAV 352 Query: 350 IKESLRLSSAS--LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTF 407 IKE +R+ L R A+ D E Y I K I + + DP I+ DP TF Sbjct: 353 IKEVMRIHPPGPLLLPRKAESD----QEVNGYLIPKGTQILINAYAIGRDPSIWTDPETF 408 Query: 408 KYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPG 446 +R+LD K F Y +PFGSG +CPG Sbjct: 409 DPERFLD----NKIDFKGQ----DYELLPFGSGRRVCPG 439 >2X2N-A nrPDB Length = 475 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 103/471 (21%), Positives = 190/471 (40%), Gaps = 70/471 (14%) Query: 31 EPPLENGLIPYLGCALQFGANPLEFLRANQRK-HGHVFTCKLMGKYVHFITNPLSYHKVL 89 +PP+ +P LG +QFG +PL F++ +R+ +FT ++GK V + +P + + Sbjct: 17 DPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFF 76 Query: 90 CHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENL 149 + ++ FG E + LN L E + Sbjct: 77 LPRNEVLSPREVYSFMVPVFG------------EGVAYAAPYPRMREQLNFLAEELTIAK 124 Query: 150 QRIMRPPVSSNSK---TAAW-VTEGMYSF---CYRVMFEAGYLTIFGRDLTRR-DTQK-A 200 + P + + A W EG + C ++ +FG DL +R D ++ A Sbjct: 125 FQNFVPAIQHEVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFA 184 Query: 201 HILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENL-QKRESISELISL 259 +L +++ VF ++ LP+ H AR +L + L + +K ++++ S Sbjct: 185 QLLAKMESSLIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKAAAVNKDSST 244 Query: 260 RMFLNDTLS-TFDDLEKAKTHLV------VLWASQANTIPATFWSLFQM-----IRNPEA 307 L+ LS + D H V ++A Q + T WS+ + +++ EA Sbjct: 245 SDLLSGLLSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEA 304 Query: 308 MKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTA 366 ++ EE L N + ++++P + +ES+R L + R Sbjct: 305 LRKEIEEFP---------AQLNYNNV------MDEMPFAERCARESIRRDPPLLMLMRKV 349 Query: 367 KEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCN 426 D + GSY + K DIIA P L H D E +P+P ++D DE Sbjct: 350 MADVKV----GSYVVPKGDIIACSPLLSHHDEEAFPEPR--RWDPERDE----------- 392 Query: 427 GLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCP 477 K++ ++ FG+G C G+ F + ++K L ++ +L+ + P Sbjct: 393 --KVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPDP 441 >2VE3-A nrPDB Length = 444 Score = 68.2 bits (165), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 99/454 (21%), Positives = 184/454 (40%), Gaps = 59/454 (12%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCH 91 PP + GL P+LG L F N +F + Q++ G +F +L GK V FI+ L+ ++ L Sbjct: 14 PPGDFGL-PWLGETLNF-LNDGDFGKKRQQQFGPIFKTRLFGKNVIFISGALA-NRFLFT 70 Query: 92 GKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQR 151 + ++ ++ G ++ G + + L+S M +Q Sbjct: 71 KEQETFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLDSYLPKMDGIVQG 130 Query: 152 IMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQ 211 + +N W Y R+ F+ G ++ Q + + + Q Sbjct: 131 YLEQWGKANE--VIW-----YPQLRRMTFDVAATLFMGEKVS----QNPQLFPWFETYIQ 179 Query: 212 FDKVFPALVAGLPIHMFRTAHNAR-------EKLAESLRHENLQKRESISELISLRMFLN 264 +F +L LP +F + AR EK+ ++ + + + +++ L++ R N Sbjct: 180 --GLF-SLPIPLPNTLFGKSQRARALLLAELEKIIKARQQQPPSEEDALGILLAARDDNN 236 Query: 265 DTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQ 324 LS L + K +++L + T+ + S ++ ++ + Sbjct: 237 QPLS----LPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIR--------------E 278 Query: 325 KVSLEGNPICLSQ---AE-LNDLPVLDSIIKESLRL-SSASLNIRTAKEDFTLHLEDGSY 379 +V E N + LSQ AE L +P LD +++E LRL R +D + Sbjct: 279 RVRQEQNKLQLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQ----GF 334 Query: 380 NIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGS 439 + K +++ H DP++YPDP F +R+ + T + ++PFG Sbjct: 335 HFPKGWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNP--------PFAHVPFGG 386 Query: 440 GATICPGRLFAIHEIKQFLILMLSYFELELIEGQ 473 G C G+ FA E+K F ++ F+ L+ GQ Sbjct: 387 GLRECLGKEFARLEMKLFATRLIQQFDWTLLPGQ 420 >6CR2-A nrPDB Length = 477 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 108/476 (22%), Positives = 199/476 (41%), Gaps = 51/476 (10%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGK--YVHFITNPLSYHKVL 89 PP+ P++G + +G +P +F + K+G +FT L+GK V+ T + + Sbjct: 6 PPVVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDF---I 62 Query: 90 CHGKYFD--WKKFHFATSAKAFG-HRSIDPMDGNTTENINDTFIK-TLQGHALNSLTESM 145 +GK D ++ + + FG H D + E F+K L AL S + Sbjct: 63 LNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLME--QKKFVKYGLTSDALRSYVPLI 120 Query: 146 MENLQRIMRPPVSSNSKTAAWVTEGMYSFC---YRVMFEAGYLTIFGRDL-TRRDTQKAH 201 + ++ ++ + A +G++ C + ++ G+++ ++ D+ A Sbjct: 121 TDEVESFVK------NSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEVRSKFDSTFAE 174 Query: 202 ILNNLD-NFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESL------RHENLQKRESIS 254 + +NLD F + + P A LP + R A A+ KL E+ R + K++S Sbjct: 175 LYHNLDMGFAPINFMLPW--APLPHNRKRDA--AQRKLTETYMEIIKARRQAGSKKDSED 230 Query: 255 ELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEE 314 + +L + + D E A + +L A Q ++ W + ++ P+ M+ +E Sbjct: 231 MVWNLMSCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQE 290 Query: 315 VKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHL 374 R L G + L+ L L + +IKE+LRL + +I A ++ + + Sbjct: 291 QIRVL---GSDLP------PLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKN-PMAV 340 Query: 375 EDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDEN-----GKTKTTFYCNGLK 429 + SY I + P + E +P+PL + R+ DEN + Y GL Sbjct: 341 DGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRW-DENIAASAEDDEKVDYGYGLV 399 Query: 430 LKYY---YMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQS 482 K Y+PFG+G C G FA ++ +++ F + G P D S Sbjct: 400 SKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVDGIPDTDYS 455 >4R1Z-A nrPDB Length = 439 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 62/253 (24%), Positives = 113/253 (44%), Gaps = 35/253 (13%) Query: 245 ENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLV-----VLWASQANTIPATFWSLF 299 +N+Q R+ + L+ + + S+ D+ + H++ + A T WS+ Sbjct: 189 DNVQ-RDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVETTTTVLKWSIA 247 Query: 300 QMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSA 359 ++ NP+ + EE+ K+ E +P ++ +LP L++ I+E LR+ Sbjct: 248 YLVHNPQVQRKIQEELD-------SKIGKERHP---QLSDRGNLPYLEATIREVLRIRPV 297 Query: 360 S--LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENG 417 S L A +D ++ G Y ++K + + +H D + + +P F R+L+E G Sbjct: 298 SPLLIPHVALQDSSV----GEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEG 353 Query: 418 KTKTTFYCNGLKL-KYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKC 476 +GL Y+PFG+G +C G A E+ FL +L F LE+ GQ Sbjct: 354 --------DGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQ--- 402 Query: 477 PPLDQSRAGLGIL 489 PL + G++ Sbjct: 403 -PLPDLQGKFGVV 414 >6B82-A nrPDB Length = 509 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 66/280 (23%), Positives = 121/280 (43%), Gaps = 42/280 (15%) Query: 225 IHMFRTAHNAREKLAESLRHE-------NLQKRESISELISLRMFLNDTLSTFDDLEKAK 277 + + R + R+KL + E N+Q R+ + L+ + + S+ D+ + Sbjct: 226 LRILRQCISIRDKLLQKKYEEHKVTYSDNVQ-RDLLDALLRAKRSSENNNSSTRDVGLTE 284 Query: 278 THLV-----VLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNP 332 H++ + A T WS+ ++ NP+ + EE+ K+ E +P Sbjct: 285 DHVLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQVQRKIQEELD-------SKIGKERHP 337 Query: 333 ICLSQAELNDLPVLDSIIKESLRLSSAS--LNIRTAKEDFTLHLEDGSYNIRKDDIIALY 390 ++ +LP L++ I E +R+ S L A +D ++ G Y ++K + + Sbjct: 338 ---QLSDRGNLPYLEATICEVMRIRPVSPLLIPHVALQDSSV----GEYTVQKGTRVVIN 390 Query: 391 PQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKY-YYMPFGSGATICPGRLF 449 +H D + + +P F R+L+E G +GL Y+PFG+G +C G Sbjct: 391 MWSLHHDEKEWKNPELFDPGRFLNEEG--------DGLCCPSGSYLPFGAGVRVCLGEAL 442 Query: 450 AIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGIL 489 A E+ FL +L F LE+ GQ PL + G++ Sbjct: 443 AKMELFLFLAWILQRFTLEMPTGQ----PLPDLQGKFGVV 478 >3EL3-A nrPDB Length = 467 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 104/477 (21%), Positives = 176/477 (36%), Gaps = 65/477 (13%) Query: 31 EPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLC 90 EPP+ G +P LG + +PL F+ + R HG V KL K V+ +TNP + Sbjct: 23 EPPVAGGGVPLLGHGWRLARDPLAFM-SQLRDHGDVVRIKLGPKTVYAVTNPELTGALAL 81 Query: 91 HGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQ 150 + Y + + G + +G T + A+ + M E Sbjct: 82 NPDYHIAGPL-WESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEE-- 138 Query: 151 RIMRPPVSSNSKTAAWV---TEGMYSFCYRVMFE-AGYLTIFGRDLTRRDTQKAHILNNL 206 +++ T W T S +RV A + G+ + R + L + Sbjct: 139 --------AHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATV 190 Query: 207 DNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDT 266 F ++ +V L ++R A + ++L +L E I+E + +D Sbjct: 191 -----FRGMYRRMVVPL-GPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDL 244 Query: 267 LSTF--------DDLEKAKTH--LVVLWASQANTIPATF-WSLFQMIRNPEAMKAATEEV 315 L+ D + + + H +V + + TI +T W L + +PE +EV Sbjct: 245 LTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEV 304 Query: 316 KRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSA--SLNIRTAKEDFTLH 373 + G+ V+ E ++ L ++I E++RL A L R E Sbjct: 305 EAV--TGGRPVAFE---------DVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAES---- 349 Query: 374 LEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYY 433 E G Y I I P + DP+ Y D L F DR+L E KY Sbjct: 350 -ELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVP---------KYA 399 Query: 434 YMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILP 490 PF +G CP F++ ++ + + + E + G D R G+ + P Sbjct: 400 MKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSN-----DAVRVGITLRP 451 >6M7X-A nrPDB Length = 484 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 55/222 (24%), Positives = 95/222 (42%), Gaps = 32/222 (14%) Query: 227 MFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWAS 286 +F+ N +K+ + L Q+ SI + LN LS D ++ L S Sbjct: 240 IFQYGDNCIQKIYQELAFSRPQQYTSIVA----ELLLNAELSP-DAIKANSMELTA--GS 292 Query: 287 QANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL 346 T+ +LF++ RNP +A +E + S+ +P Q +LP+L Sbjct: 293 VDTTVFPLLMTLFELARNPNVQQALRQE------SLAAAASISEHP----QKATTELPLL 342 Query: 347 DSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPL 405 + +KE+LRL L + R A D L +Y+I ++ ++ + +P ++P P Sbjct: 343 RAALKETLRLYPVGLFLERVASSDLVLQ----NYHIPAGTLVRVFLYSLGRNPALFPRPE 398 Query: 406 TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGR 447 + R+LD G + +Y++PFG G C GR Sbjct: 399 RYNPQRWLDIRGSGRN----------FYHVPFGFGMRQCLGR 430 >4KPA-A nrPDB Length = 494 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 54/192 (28%), Positives = 90/192 (46%), Gaps = 29/192 (15%) Query: 280 LVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAE 339 + L A T ++L+ +++NP ++ A EE R L +P+ S + Sbjct: 283 ITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVL----------VDPVP-SYKQ 331 Query: 340 LNDLPVLDSIIKESLRL-SSASLNIRTAKEDFTLHLEDGSYNIRK-DDIIALYPQLMHLD 397 + L + ++ E+LRL +A AKED L G Y + K D+++ L PQL H D Sbjct: 332 VKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVL---GGEYPLEKGDELMVLIPQL-HRD 387 Query: 398 PEIYPDPLT-FKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQ 456 I+ D + F+ +R+ + + + F PFG+G C G+ FA+HE Sbjct: 388 KTIWGDDVEEFRPERFENPSAIPQHAF-----------KPFGNGQRACIGQQFALHEATL 436 Query: 457 FLILMLSYFELE 468 L +ML +F+ E Sbjct: 437 VLGMMLKHFDFE 448 >5VEU-A nrPDB Length = 480 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 45/198 (22%), Positives = 86/198 (43%), Gaps = 25/198 (12%) Query: 272 DLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGN 331 DLE A ++ ++A T ++L+++ +P+ + +E+ L N Sbjct: 271 DLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP------ 324 Query: 332 PICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALY 390 + + + LD ++ E+LRL ++ + RT K+D +E I K ++ + Sbjct: 325 ----TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKD----VEINGVFIPKGSMVVIP 376 Query: 391 PQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA 450 +H DP+ + +P F+ +R+ + Y Y PFG+G C G FA Sbjct: 377 TYALHHDPKYWTEPEEFRPERFSKKKDSIDP----------YIYTPFGTGPRNCIGMRFA 426 Query: 451 IHEIKQFLILMLSYFELE 468 + +K LI +L F + Sbjct: 427 LMNMKLALIRVLQNFSFK 444 >6AYB-A nrPDB Length = 466 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 56/232 (24%), Positives = 102/232 (43%), Gaps = 30/232 (12%) Query: 272 DLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGN 331 D+ + + L+A Q + + W+L +I N K E+V++ E + G+ Sbjct: 255 DVHRIGILIAGLFAGQHTSSITSSWTLMNVISN----KKVLEKVRKEQEE------IMGS 304 Query: 332 PICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALY 390 L ++ + L++ +KE+LR+ + I R A++ E Y I K +I+ + Sbjct: 305 DKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKP----RECEQYIIPKGNILVVS 360 Query: 391 PQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA 450 P + + Y +P F +R + K KY +PFG+G C G FA Sbjct: 361 PSVAGRCTDTYTNPDVFDPERLTERKEHEK---------FKYGAVPFGAGRHKCIGENFA 411 Query: 451 IHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFK 502 + ++K + ++L YF++E I K P + +G PP +YK + Sbjct: 412 LLQVKSIISILLRYFDMEYI---GKIPDPSYTSLVVGPSPP---TRMRYKLR 457 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 21/51 (41%), Positives = 33/51 (64%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNP 82 PP LIPY+G + F NP++F+ N +K+G VFT ++GK + F+ +P Sbjct: 12 PPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLNHP 62 >3K9V-A nrPDB Length = 482 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 50/217 (23%), Positives = 97/217 (44%), Gaps = 31/217 (14%) Query: 285 ASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLP 344 A+ T + W L+ + RNP+A + +EV+ L + Q E +L ++P Sbjct: 294 AAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPD-NQTPRAE---------DLRNMP 343 Query: 345 VLDSIIKESLRLS-SASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPD 403 L + +KES+RL+ S RT + L G Y + K ++ L Q++ + + D Sbjct: 344 YLKACLKESMRLTPSVPFTTRTLDKPTVL----GEYALPKGTVLTLNTQVLGSSEDNFED 399 Query: 404 PLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLS 463 F+ +R+L + K + ++PFG G +C GR A ++ L ++ Sbjct: 400 SHKFRPERWLQKEKKINP----------FAHLPFGIGKRMCIGRRLAELQLHLALCWIIQ 449 Query: 464 YFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYK 500 +++ + + P++ LGIL P ++ ++ Sbjct: 450 KYDIVATDNE----PVEM--LHLGILVPSRELPIAFR 480 >6DA2-A nrPDB Length = 487 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 62/284 (21%), Positives = 114/284 (40%), Gaps = 34/284 (11%) Query: 196 DTQKAHILNNLDNFKQFDKVFPALVAGL--------PIHMFRTAHNAREKLAESLRHENL 247 +T+K + LD F VFP L+ L P + + +++ ES + Sbjct: 186 NTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQ 245 Query: 248 QKRESISELISLRMFLNDTLS--TFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNP 305 + R +L+ +T S DLE ++ ++A T + ++++ +P Sbjct: 246 KHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHP 305 Query: 306 EAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI-R 364 + + EE+ L N + + + LD ++ E+LRL ++ + R Sbjct: 306 DVQQKLQEEIDAVLPNKAPP----------TYDTVLQMEYLDMVVNETLRLFPIAMRLER 355 Query: 365 TAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFY 424 K+D +E I K ++ + +H DP+ + +P F +R+ +N Sbjct: 356 VCKKD----VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP-- 409 Query: 425 CNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELE 468 Y Y PFGSG C G FA+ +K LI +L F + Sbjct: 410 -------YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 446 >3MZS-A nrPDB Length = 486 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 56/198 (28%), Positives = 83/198 (41%), Gaps = 24/198 (12%) Query: 273 LEKAKTHLVVLWASQANTIPATF-WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGN 331 LE K ++ + A NT T W L++M R+ + EEV A +S Sbjct: 274 LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDIS---- 329 Query: 332 PICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYP 391 L +P+L + IKE+LRL S+ ++ E L L+D Y I ++ + Sbjct: 330 ------KMLQMVPLLKASIKETLRLHPISVTLQRYPES-DLVLQD--YLIPAKTLVQVAI 380 Query: 392 QLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAI 451 M DP + P F R+L K K + L FG G C GR A Sbjct: 381 YAMGRDPAFFSSPDKFDPTRWL---SKDKDLIHFRNLG-------FGWGVRQCVGRRIAE 430 Query: 452 HEIKQFLILMLSYFELEL 469 E+ FLI +L F++E+ Sbjct: 431 LEMTLFLIHILENFKVEM 448 >4R20-A nrPDB Length = 486 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 46/162 (28%), Positives = 77/162 (47%), Gaps = 19/162 (11%) Query: 331 NPICLSQAELNDLPVLDSIIKESLRLSSAS--LNIRTAKEDFTLHLEDGSYNIRKDDIIA 388 P CLS + LP+LD+++ E +R+ S L A +D +L G +++ K + Sbjct: 325 RPPCLS--DRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSL----GGHSVPKGTRVL 378 Query: 389 LYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRL 448 + +H DP+ + P F +R+L+ +GK KT + ++PFG+G +C G Sbjct: 379 VNMWAIHHDPKHWDQPEQFNPERFLEPSGKKKT---------QSSFLPFGAGPRVCVGES 429 Query: 449 FAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILP 490 A E+ F+ L F +A P L Q R G+ + P Sbjct: 430 LARIELFLFVSRPLQRFSFS-CPSEASLPDL-QGRFGVVLQP 469 >6C94-A nrPDB Length = 497 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 52/244 (21%), Positives = 90/244 (36%), Gaps = 21/244 (8%) Query: 226 HMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWA 285 H R + L + E +Q R + L L ++ D + ++ Sbjct: 234 HTDRVIRQRKAALQDEKEREKIQNRRHLDFLDILLDVRGESGVQLSDTDLRAEVDTFMFE 293 Query: 286 SQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPV 345 T W L+ M PE + EEV+ L G+ +L + Sbjct: 294 GHDTTTSGISWFLYCMALYPEHQQRCREEVREIL----------GDQDSFQWEDLAKMTY 343 Query: 346 LDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPL 405 L +KE RL + + DG ++ +I+L+ +H + +++PDP Sbjct: 344 LTMCMKECFRLYPPVPQVYRQLSK-PVSFVDGR-SLPAGSLISLHIYALHRNSDVWPDPE 401 Query: 406 TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 F R+ EN + Y ++PF +G C G+ FA++E+K L L F Sbjct: 402 VFDPLRFSPENSSGRHP---------YAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRF 452 Query: 466 ELEL 469 E + Sbjct: 453 EFSV 456 >3N9Z-A nrPDB Length = 487 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 91/213 (42%), Gaps = 29/213 (13%) Query: 259 LRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATF-WSLFQMIRNPEAMKAATEEVKR 317 L L D+ +F+D++ T ++ A +T T W L++M RN + EV Sbjct: 262 LYRLLGDSKMSFEDIKANVTEML---AGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLA 318 Query: 318 TLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLED 376 A +G+ + Q +P+L + IKE+LRL S+ + R D L Sbjct: 319 ARHQA------QGDMATMLQL----VPLLKASIKETLRLHPISVTLQRYLVNDLVLR--- 365 Query: 377 GSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMP 436 Y I ++ + + +P + DP F R+L ++ T++ N + Sbjct: 366 -DYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD--KNITYFRN--------LG 414 Query: 437 FGSGATICPGRLFAIHEIKQFLILMLSYFELEL 469 FG G C GR A E+ FLI ML F +E+ Sbjct: 415 FGWGVRQCLGRRIAELEMTIFLINMLENFRVEI 447 >3E6I-A nrPDB Length = 476 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 48/210 (22%), Positives = 84/210 (40%), Gaps = 22/210 (10%) Query: 282 VLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELN 341 + +A T + L +++ PE + EE+ R + G + + Sbjct: 275 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI----------GPSRIPAIKDRQ 324 Query: 342 DLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIY 401 ++P +D+++ E R +L + T Y I K ++ + D + + Sbjct: 325 EMPYMDAVVHEIQRF--ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF 382 Query: 402 PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILM 461 PDP FK + +L+ENGK K Y+ PF +G +C G A E+ L + Sbjct: 383 PDPEKFKPEHFLNENGK---------FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAI 433 Query: 462 LSYFELELIEGQAKCPPLDQSRAGLGILPP 491 L +F L+ + K L G G +PP Sbjct: 434 LQHFNLKPLV-DPKDIDLSPIHIGFGCIPP 462 >4ZGX-A nrPDB Length = 489 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 42/178 (23%), Positives = 77/178 (43%), Gaps = 26/178 (14%) Query: 272 DLEKAKTHLVVLWASQANTIP-ATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEG 330 LE K + + L A +T +LF++ RNP+ + +E + S+ Sbjct: 277 SLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE------SLAAAASISE 330 Query: 331 NPICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIAL 389 +P Q +LP+L + +KE+LRL L + R D L +Y+I ++ + Sbjct: 331 HP----QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQ----NYHIPAGTLVQV 382 Query: 390 YPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGR 447 + + + ++P P + R+LD G + ++++PFG G C GR Sbjct: 383 FLYSLGRNAALFPRPERYNPQRWLDIRGSGRN----------FHHVPFGFGMRQCLGR 430 >2NNH-A nrPDB Length = 476 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 77/317 (24%), Positives = 129/317 (40%), Gaps = 37/317 (11%) Query: 192 LTRRDTQKAHILNN-----LDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHEN 246 L +R + ILN+ +NF FP + ++ T REK+ E + Sbjct: 179 LMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLD 238 Query: 247 LQKRESISE--LISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATF-WSLFQMIR 303 + + LI + ++ S F+ +E + L+ + T T + L +++ Sbjct: 239 VNNPRDFIDCFLIKMEQEKDNQKSEFN-IENLVGTVADLFVAGTETTSTTLRYGLLLLLK 297 Query: 304 NPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI 363 +PE EE+ + G+ S C+ + + +P D+++ E R S L Sbjct: 298 HPEVTAKVQEEIDHVI---GRHRSP-----CMQ--DRSHMPYTDAVVHEIQRYSD--LVP 345 Query: 364 RTAKEDFTLHLEDGSYNIRKDD-IIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTT 422 T + +Y I K I+AL ++H D E +P+P F +LD+NG Sbjct: 346 TGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKE-FPNPNIFDPGHFLDKNG----- 399 Query: 423 FYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQS 482 K Y+MPF +G IC G A E+ FL +L F L+ ++ L+ + Sbjct: 400 ----NFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKN---LNTT 452 Query: 483 RAGLGI--LPPLNDIEF 497 GI LPP I F Sbjct: 453 AVTKGIVSLPPSYQICF 469 >2HI4-A nrPDB Length = 495 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 51/182 (28%), Positives = 77/182 (42%), Gaps = 22/182 (12%) Query: 293 ATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKE 352 A WSL ++ PE + +E+ T+ ++ L P LP L++ I E Sbjct: 301 AISWSLMYLVTKPEIQRKIQKELD-TVIGRERRPRLSDRP---------QLPYLEAFILE 350 Query: 353 SLRLSS-ASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYD 410 + R SS I + D TL +G Y +K + Q+ H DPE++ DP F+ + Sbjct: 351 TFRHSSFLPFTIPHSTTRDTTL---NGFYIPKKCCVFVNQWQVNH-DPELWEDPSEFRPE 406 Query: 411 RYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELI 470 R+L +G L M FG G C G + A EI FL ++L E + Sbjct: 407 RFLTADGTAINK------PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP 460 Query: 471 EG 472 G Sbjct: 461 PG 462 >3S79-A nrPDB Length = 503 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 49/195 (25%), Positives = 85/195 (43%), Gaps = 30/195 (15%) Query: 280 LVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAE 339 L +L A+ + F+ LF + ++P +A +E++ + K+ + Sbjct: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKID-----------D 349 Query: 340 LNDLPVLDSIIKESLRLSSA-SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDP 398 + L V+++ I ES+R L +R A ED + DG Y ++K I L MH Sbjct: 350 IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI---DG-YPVKKGTNIILNIGRMH-RL 404 Query: 399 EIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFL 458 E +P P F + + K Y Y+ PFG G C G+ A+ +K L Sbjct: 405 EFFPKPNEFTLENF------AKNVPY-------RYFQPFGFGPRGCAGKYIAMVMMKAIL 451 Query: 459 ILMLSYFELELIEGQ 473 + +L F ++ ++GQ Sbjct: 452 VTLLRRFHVKTLQGQ 466 >5UYS-A nrPDB Length = 494 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 45/199 (22%), Positives = 85/199 (42%), Gaps = 20/199 (10%) Query: 282 VLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELN 341 + A T W+L ++ NP+ K EE+ Q V P ++ N Sbjct: 281 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEID-------QNVGFSRTPTI---SDRN 330 Query: 342 DLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIY 401 L +L++ I+E LRL + + K + + + + + + II L+ +H + + + Sbjct: 331 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWA--LHHNEKEW 388 Query: 402 PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILM 461 P F +R+L+ G + + Y+PFG+G C G + A E+ + + Sbjct: 389 HQPDQFMPERFLNPAGTQLISPSVS-------YLPFGAGPRSCIGEILARQELFLIMAWL 441 Query: 462 LSYFELELIEGQAKCPPLD 480 L F+LE + + P L+ Sbjct: 442 LQRFDLE-VPDDGQLPSLE 459 >1N6B-A nrPDB Length = 473 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 66/263 (25%), Positives = 115/263 (43%), Gaps = 35/263 (13%) Query: 216 FPALVAGLP-IH--MFRTAHNAREKLAESLR-HENLQKRESISELISLRMFLNDTLSTFD 271 FPAL+ P IH + + A + + E ++ H+ L + + I + + + Sbjct: 201 FPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVNNPRDFIDCFLI---KMEQEN 257 Query: 272 DLEKAKTHLVV----LWASQANTIPATF-WSLFQMIRNPEAMKAATEEVKRTLENAGQKV 326 +LE LV+ L+ + T T +SL ++++PE EE++R + G+ Sbjct: 258 NLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVAARVQEEIERVI---GRHR 314 Query: 327 SLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKD-D 385 S C+ + + +P D++I E R L T + +Y I K D Sbjct: 315 S-----PCMQ--DRSRMPYTDAVIHEIQRF--IDLLPTNLPHAVTRDVRFRNYFIPKGTD 365 Query: 386 IIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICP 445 II ++H D + +P+P F +LDE+G K + Y+MPF +G +C Sbjct: 366 IITSLTSVLH-DEKAFPNPKVFDPGHFLDESGNFKKS---------DYFMPFSAGKRMCV 415 Query: 446 GRLFAIHEIKQFLILMLSYFELE 468 G A E+ FL +L F+L+ Sbjct: 416 GEGLARMELFLFLTSILQNFKLQ 438 >5W0C-A nrPDB Length = 477 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 92/222 (41%), Gaps = 34/222 (15%) Query: 273 LEKAKTHLVVLWASQANTIPATF-WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGN 331 +E + V L+ + T T ++L ++++PE EE++R + G+ S Sbjct: 267 IESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVI---GRNRS---- 319 Query: 332 PICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYP 391 C+ + + +P D+++ E R L + T ++ +Y I K I + Sbjct: 320 -PCMQ--DRSHMPYTDAVVHEVQRY--IDLLPTSLPHAVTCDIKFRNYLIPKGTTILISL 374 Query: 392 QLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAI 451 + D + +P+P F +LDE G K + Y+MPF +G IC G A Sbjct: 375 TSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS---------KYFMPFSAGKRICVGEALAG 425 Query: 452 HEIKQFLILMLSYFELE------------LIEGQAKCPPLDQ 481 E+ FL +L F L+ ++ G A PP Q Sbjct: 426 MELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQ 467 >3MDV-A nrPDB Length = 456 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 50/192 (26%), Positives = 75/192 (39%), Gaps = 31/192 (16%) Query: 296 WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLR 355 +++ ++ R PE + EV + G+ L +L L L ++KESLR Sbjct: 265 FTVMELSRQPEIVARLQAEVDEVI----------GSKRYLDFEDLGRLQYLSQVLKESLR 314 Query: 356 LSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDE 415 L + E+ TL DG + + + +M + DPLTF DR Sbjct: 315 LYPPAWGTFRLLEEETLI--DG-VRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDR---- 367 Query: 416 NGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEG--- 472 F K ++ Y PF G C G+ FA E+K + +L E L+ G Sbjct: 368 -------FGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRF 420 Query: 473 ----QAKCPPLD 480 QA PLD Sbjct: 421 GLQEQATLKPLD 432 >3DBM-A nrPDB Length = 473 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 40/169 (23%), Positives = 76/169 (44%), Gaps = 27/169 (15%) Query: 313 EEVKRTLENAGQ-KVSLEGNPICLSQAELNDLPVLDSIIKESLRLSS-ASLNIRTAKEDF 370 EE++ +++ G V+LE + +P+ S++ ESLR+ AK +F Sbjct: 305 EEIRGAIKSYGDGNVTLEA---------IEQMPLTKSVVYESLRIEPPVPPQYGKAKSNF 355 Query: 371 TLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYL-DENGKTKTTFYCNGLK 429 T+ D ++ ++K +++ Y DP+++ P + DR++ D K ++ NG Sbjct: 356 TIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDGEALLKYVWWSNG-- 413 Query: 430 LKYYYMPFGSGATI----CPGRLFAIHEIKQFLILML---SYFELELIE 471 P T+ C G+ F + + F+I + FE+EL E Sbjct: 414 ------PETESPTVENKQCAGKDFVVLITRLFVIELFRRYDSFEIELGE 456 >4H1N-A nrPDB Length = 479 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 57/224 (25%), Positives = 89/224 (39%), Gaps = 33/224 (14%) Query: 280 LVVLWASQANTIPATF-WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQA 338 ++ L+A+ T T + M++ P TE V++ +E Q + P +A Sbjct: 273 VLSLFAAGTETTSTTLRYGFLLMLKYPHV----TERVQKEIE---QVIGSHRPPALDDRA 325 Query: 339 ELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKD-DIIALYPQLMHLD 397 ++ P D++I E RL L T + Y I K+ ++ + +H D Sbjct: 326 KM---PYTDAVIHEIQRL--GDLIPFGVPHTVTKDTQFRGYVIPKNTEVFPVLSSALH-D 379 Query: 398 PEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQF 457 P + P TF +LD NG LK +MPF G IC G A E+ F Sbjct: 380 PRYFETPNTFNPGHFLDANG---------ALKRNEGFMPFSLGKRICLGEGIARTELFLF 430 Query: 458 LILMLSYFELELIEGQAKCPPLD----QSRAGLGILPPLNDIEF 497 +L F + + PP D +G+G +PP I F Sbjct: 431 FTTILQNFSI-----ASPVPPEDIDLTPRESGVGNVPPSYQIRF 469 >3QZ1-A nrPDB Length = 496 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 71/175 (40%), Gaps = 28/175 (16%) Query: 296 WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLR 355 W++ ++ +PE + EE+ R L G S ++ + LP+L++ I E LR Sbjct: 301 WAVAFLLHHPEIQRRLQEELDREL-GPGASCSR------VTYKDRARLPLLNATIAEVLR 353 Query: 356 LSSA---SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRY 412 L +L RT + Y+I + ++ Q HLD ++ P F+ DR+ Sbjct: 354 LRPVVPLALPHRTTRPSSIF-----GYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRF 408 Query: 413 LDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFEL 467 L+ + FG GA +C G A E+ L +L F L Sbjct: 409 LEPGANPSA-------------LAFGCGARVCLGESLARLELFVVLARLLQAFTL 450 >4GQS-A nrPDB Length = 477 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 87/213 (40%), Gaps = 35/213 (16%) Query: 282 VLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELN 341 +L A T ++L ++++PE EE++R V +P C+ + Sbjct: 277 LLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERV-------VGRNRSP-CMQ--DRG 326 Query: 342 DLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDD-IIALYPQLMHLDPEI 400 +P D+++ E R L + T ++ +Y I K I+ ++H + E Sbjct: 327 HMPYTDAVVHEVQRY--IDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKE- 383 Query: 401 YPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLIL 460 +P+P F +LDE G K + Y+MPF +G IC G A E+ FL Sbjct: 384 FPNPEMFDPRHFLDEGGNFKKS---------NYFMPFSAGKRICVGEGLARMELFLFLTF 434 Query: 461 MLSYFELE------------LIEGQAKCPPLDQ 481 +L F L+ ++ G A PP Q Sbjct: 435 ILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 467 >5E58-A nrPDB Length = 493 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/218 (22%), Positives = 82/218 (37%), Gaps = 22/218 (10%) Query: 280 LVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAE 339 L + +A T + M++ P + +E+ + + G+ + + Sbjct: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVI----------GSHRLPTLED 342 Query: 340 LNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPE 399 +P D++I E R S + I + L G + ++ + +H DP+ Sbjct: 343 RTKMPYTDAVIHEIQRFSDLA-PIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALH-DPQ 400 Query: 400 IYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLI 459 + P TF D +LD NG LK +MPF G IC G A +E+ F Sbjct: 401 YFEQPGTFNPDHFLDANG---------ALKKSEAFMPFSIGKRICLGEGIARNELFLFFT 451 Query: 460 LMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEF 497 +L F + K L +G+G +P I F Sbjct: 452 TILQNFSVS-SSVAPKDIDLSPKESGIGKVPQTYQISF 488 >3IBD-A nrPDB Length = 476 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 81/228 (35%), Gaps = 30/228 (13%) Query: 280 LVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAE 339 L + +A T + M++ P E V R +E Q + P +A+ Sbjct: 274 LSLFFAGTETTSTTLRYGFLLMLKYPHV----AERVYREIE---QVIGPHRPPELHDRAK 326 Query: 340 LNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPE 399 + P +++I E R S L T H Y I KD + L DP Sbjct: 327 M---PYTEAVIYEIQRFSD--LLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPH 381 Query: 400 IYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLI 459 + P F D +LD NG K T ++PF G IC G A E+ F Sbjct: 382 YFEKPDAFNPDHFLDANGALKKT---------EAFIPFSLGKRICLGEGIARAELFLFFT 432 Query: 460 LMLSYFELELIEGQAKCPPLD----QSRAGLGILPPLNDIEFKYKFKH 503 +L F + + P D G+G +PP I F + H Sbjct: 433 TILQNFSM-----ASPVAPEDIDLTPQECGVGKIPPTYQIRFLPRHHH 475 >5VBU-A nrPDB Length = 476 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 47/185 (25%), Positives = 75/185 (40%), Gaps = 31/185 (16%) Query: 286 SQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPV 345 + ANT+ W++ ++ +PE + EE+ L G S P + LP+ Sbjct: 277 TTANTL---SWAVVFLLHHPEIQQRLQEELDHEL---GPGASSSRVPY----KDRARLPL 326 Query: 346 LDSIIKESLRLSSA---SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYP 402 L++ I E LRL +L RT + Y+I + +I Q HLD ++ Sbjct: 327 LNATIAEVLRLRPVVPLALPHRTTRPSSI-----SGYDIPEGTVIIPNLQGAHLDETVWE 381 Query: 403 DPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILML 462 P F DR+L+ ++ + FG GA +C G A E+ L +L Sbjct: 382 RPHEFWPDRFLEPGKNSRA-------------LAFGCGARVCLGEPLARLELFVVLTRLL 428 Query: 463 SYFEL 467 F L Sbjct: 429 QAFTL 433 >5E0E-A nrPDB Length = 463 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 25/71 (35%), Positives = 32/71 (45%), Gaps = 9/71 (12%) Query: 397 DPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQ 456 DP+ + P TF D +LD NG LK +MPF G IC G A +E+ Sbjct: 370 DPQYFEQPDTFNPDHFLDANG---------ALKKSEAFMPFSIGKRICLGEGIARNELFL 420 Query: 457 FLILMLSYFEL 467 F +L F L Sbjct: 421 FFTTILQNFSL 431 >2RCM-A nrPDB Length = 495 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 29/158 (18%), Positives = 69/158 (43%), Gaps = 16/158 (10%) Query: 312 TEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSS-ASLNIRTAKEDF 370 EE++ +++ G + L+ + + + S++ E LR + AK+D Sbjct: 322 AEEIRSVIKSNGGE---------LTMGAIEKMELTKSVVYECLRFEPPVTAQYGRAKKDL 372 Query: 371 TLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKT--KTTFYCNGL 428 + D ++ ++ +++ Y L DP+I+ F +R++ E G+ + + NG Sbjct: 373 VIESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLLRHVLWSNGP 432 Query: 429 KLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFE 466 + + + G C G+ F + + F+I + ++ Sbjct: 433 ETETPTV----GNKQCAGKDFVVLVARLFVIEIFRRYD 466 >6IQ5-A nrPDB Length = 463 Score = 36.6 bits (83), Expect = 0.028, Method: Compositional matrix adjust. Identities = 39/148 (26%), Positives = 62/148 (41%), Gaps = 15/148 (10%) Query: 272 DLEKAKTHLV-VLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEG 330 DLE + + ASQ A W L R P+ E+ Q V + Sbjct: 249 DLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELD-------QVVGRDR 301 Query: 331 NPICLSQAELNDLPVLDSIIKESLRLSS-ASLNIRTAKEDFTLHLEDGSYNIRKDDIIAL 389 P Q +LP + + + E++R SS + I A T L Y+I KD ++ + Sbjct: 302 LPCMGDQP---NLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVL---GYHIPKDTVVFV 355 Query: 390 YPQLMHLDPEIYPDPLTFKYDRYLDENG 417 ++ DP +P+P F R+LD++G Sbjct: 356 NQWSVNHDPVKWPNPENFDPARFLDKDG 383 >3NC3-A nrPDB Length = 441 Score = 36.2 bits (82), Expect = 0.035, Method: Compositional matrix adjust. Identities = 43/147 (29%), Positives = 61/147 (41%), Gaps = 16/147 (10%) Query: 310 AATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSS-ASLNIRTAKE 368 AATE +TL A L NP ++ L D ++ I E+LR L R + Sbjct: 269 AATEPADKTL--ALMIYHLLNNPEQMNDV-LADRSLVPRAIAETLRYKPPVQLIPRQLSQ 325 Query: 369 DFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGL 428 D + G I+KD I+ + DPE + P F R E+ K+ F Sbjct: 326 DTVV----GGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHR---EDLGIKSAFSGAA- 377 Query: 429 KLKYYYMPFGSGATICPGRLFAIHEIK 455 ++ FGSG C G FA +EI+ Sbjct: 378 ----RHLAFGSGIHNCVGTAFAKNEIE 400 >6DCD-A nrPDB Length = 424 Score = 36.2 bits (82), Expect = 0.037, Method: Compositional matrix adjust. Identities = 50/224 (22%), Positives = 92/224 (41%), Gaps = 26/224 (11%) Query: 262 FLNDTLSTFDDLEKAKTHLVVLWASQANTIP-ATFWSLFQMIRNPEAMKAATEEVKRTLE 320 +L+D S + + + + VL A T P + + ++R+ + AA +E L Sbjct: 202 WLDDKFSAYIEDRRRQPRNDVLTALATATYPDGSTPEVIDVVRSATFLFAAGQETTAKLL 261 Query: 321 NAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSS-ASLNIRTAKEDFTLHLEDGSY 379 A +V G+ + + + ++ + I+ESLR+ S + R A++ T+ G Sbjct: 262 TAAMRVL--GDRPDIQRRLRENRSLIPNFIEESLRMDSPVKSDSRLARKRTTV----GGL 315 Query: 380 NIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGS 439 +I ++ + P + DP + DP F+ DR N + +M F Sbjct: 316 DIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR---PNVRE--------------HMAFAR 358 Query: 440 GATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSR 483 G CPG A E + L +L L++ + + P D R Sbjct: 359 GVHSCPGGPLARVEGRVSLERILDRM-LDIAINEDRHGPADDRR 401 >3DL9-A nrPDB Length = 479 Score = 35.4 bits (80), Expect = 0.061, Method: Compositional matrix adjust. Identities = 64/307 (20%), Positives = 109/307 (35%), Gaps = 48/307 (15%) Query: 185 LTIFGRDLTRRDTQKAHILNNLDNFKQFD--------KVFPALVAGLPI----HMFRTAH 232 L IFG T DT H++ + FP + LP +FR A Sbjct: 167 LIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP-WIGILPFGKHQQLFRNAA 225 Query: 233 NAREKLAESLRHENLQKRESISE------LISLRMFLNDTLSTF--DDLEKAKTHLVVLW 284 + L+ + ++ ++ + + L + ND STF ++L + L++ Sbjct: 226 VVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII-- 283 Query: 285 ASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLP 344 A T W++ M P +E+ + G+ S + +P Sbjct: 284 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP----------SWDDKCKMP 333 Query: 345 VLDSIIKESLRLSS-ASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYP 402 ++++ E LR + L I ED + Y+I K + +H D + + Sbjct: 334 YTEAVLHEVLRFCNIVPLGIFHATSEDAVVR----GYSIPKGTTVITNLYSVHFDEKYWR 389 Query: 403 DPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILML 462 DP F +R+LD +G K +PF G C G A E+ F +L Sbjct: 390 DPEVFHPERFLDSSGY---------FAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALL 440 Query: 463 SYFELEL 469 F L Sbjct: 441 QRFHLHF 447 >3TBG-A nrPDB Length = 479 Score = 35.0 bits (79), Expect = 0.067, Method: Compositional matrix adjust. Identities = 43/215 (20%), Positives = 82/215 (38%), Gaps = 35/215 (16%) Query: 268 STFDDLEKAKTHLVVLWASQANTIPATF-WSLFQMIRNPEAMKAATEEVKRTLENAGQKV 326 S+F+D E + + L+++ T T W L MI +P+ + +E+ + GQ Sbjct: 266 SSFND-ENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVI---GQ-- 319 Query: 327 SLEGNPICLSQAELND---LPVLDSIIKESLRLSSA---SLNIRTAKEDFTLHLEDGSYN 380 + + E+ D +P ++I E R + T+++ +E + Sbjct: 320 --------VRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRD-----IEVQGFR 366 Query: 381 IRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSG 440 I K + + D ++ P F + +LD G ++PF +G Sbjct: 367 IPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGH---------FVKPEAFLPFSAG 417 Query: 441 ATICPGRLFAIHEIKQFLILMLSYFELELIEGQAK 475 C G A E+ F +L +F + GQ + Sbjct: 418 RRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR 452 >6DWN-A nrPDB Length = 491 Score = 35.0 bits (79), Expect = 0.086, Method: Compositional matrix adjust. Identities = 41/182 (22%), Positives = 74/182 (40%), Gaps = 23/182 (12%) Query: 293 ATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKE 352 A WSL ++ NP + EE+ T+ ++ L ++ + LP +++ I E Sbjct: 298 AISWSLMYLVMNPRVQRKIQEELD-TVIGRSRRPRL---------SDRSHLPYMEAFILE 347 Query: 353 SLRLSS-ASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYD 410 + R SS I + D +L + I K + + ++ D +++ +P F + Sbjct: 348 TFRHSSFVPFTIPHSTTRDTSLK----GFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPE 403 Query: 411 RYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELI 470 R+L +G L + FG G C G A E+ FL ++L E + Sbjct: 404 RFLTPDGAIDKV-------LSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 456 Query: 471 EG 472 G Sbjct: 457 LG 458 >2PG7-A nrPDB Length = 476 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 44/196 (22%), Positives = 76/196 (38%), Gaps = 40/196 (20%) Query: 283 LWASQANTIPATF-WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELN 341 L+ T+ T + ++++PE EE+ R + Q P +A++ Sbjct: 276 LFVGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQ-------PKFEDRAKM- 327 Query: 342 DLPVLDSIIKESLRLSSA---SLNIRTAKE----DFTLHLEDGSYNIRKDDIIALYPQLM 394 P ++++I E R SL R K+ DF L G+ +YP L Sbjct: 328 --PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDF--FLPKGT---------EVYPMLG 374 Query: 395 HL--DPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIH 452 + DP + +P F +L+E G+ K + ++PF G C G A Sbjct: 375 SVLRDPSFFSNPQDFNPQHFLNEKGQFKKS---------DAFVPFSIGKRNCFGEGLARM 425 Query: 453 EIKQFLILMLSYFELE 468 E+ F ++ F L+ Sbjct: 426 ELFLFFTTVMQNFRLK 441 >4PWV-A nrPDB Length = 446 Score = 32.7 bits (73), Expect = 0.40, Method: Compositional matrix adjust. Identities = 27/120 (22%), Positives = 48/120 (40%), Gaps = 23/120 (19%) Query: 346 LDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDP 404 L+S +E LR ++ +++ R A D LH I D++ L+ + D E++ DP Sbjct: 303 LESATEEVLRWATPAMHFGRRAVTDMELH----GQVIAAGDVVTLWNNSANRDEEVFADP 358 Query: 405 LTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSY 464 F +R ++ ++ FG G C G E+ L + +Y Sbjct: 359 YAFDLNRSPNK------------------HITFGYGPHFCLGAYLGRAEVHALLDALRTY 400 >1CPT-A nrPDB Length = 428 Score = 32.0 bits (71), Expect = 0.58, Method: Compositional matrix adjust. Identities = 34/143 (23%), Positives = 65/143 (45%), Gaps = 24/143 (16%) Query: 321 NAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLN-IRTAKEDFTLHLEDGSY 379 + G + L NP L+ A+ +D ++ ++ E++R ++ + +RTA D + + Sbjct: 276 SGGAIIGLSRNPEQLALAK-SDPALIPRLVDEAVRWTAPVKSFMRTALADTEVRGQ---- 330 Query: 380 NIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGS 439 NI++ D I L + D E++ +P F R+ + ++ FG Sbjct: 331 NIKRGDRIMLSYPSANRDEEVFSNPDEFDITRFPNR------------------HLGFGW 372 Query: 440 GATICPGRLFAIHEIKQFLILML 462 GA +C G+ A E+K F +L Sbjct: 373 GAHMCLGQHLAKLEMKIFFEELL 395 >5L94-A nrPDB Length = 410 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 32/122 (26%), Positives = 46/122 (37%), Gaps = 23/122 (18%) Query: 345 VLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPD 403 +L S I+E LR S + R KED TL ++ + + + H D E + D Sbjct: 274 LLPSGIEEVLRYRSPVQALHRIVKEDVTL----AGKKLKAGEHVVPWMGSAHRDAEYFED 329 Query: 404 PLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLS 463 P FK DR + +M FG G C G A E K L ++ Sbjct: 330 PEVFKIDRKPN------------------VHMAFGRGIHFCLGAPLARIEAKIMLAELID 371 Query: 464 YF 465 + Sbjct: 372 RY 373 >1WIY-A nrPDB Length = 389 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 28/68 (41%), Gaps = 11/68 (16%) Query: 401 YPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLIL 460 +P+ F+ +R+L E G Y PFG G +C GR FA+ E L Sbjct: 304 FPEGEAFQPERFLAERGTPSGR-----------YFPFGLGQRLCLGRDFALLEGPIVLRA 352 Query: 461 MLSYFELE 468 F L+ Sbjct: 353 FFRRFRLD 360 >2IJ7-A nrPDB Length = 396 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 18/76 (23%), Positives = 34/76 (44%), Gaps = 17/76 (22%) Query: 371 TLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKL 430 T ++ G +RK +++ + + + DPE +P+P + + DR T+ Sbjct: 289 TADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDR------PNPTS-------- 334 Query: 431 KYYYMPFGSGATICPG 446 ++ FG G CPG Sbjct: 335 ---HLAFGRGQHFCPG 347 >5HIW-A nrPDB Length = 398 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 34/122 (27%), Positives = 47/122 (38%), Gaps = 23/122 (18%) Query: 345 VLDSIIKESLR-LSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPD 403 +L I+ES R SSA+ +R + + T+ G + I+ L H D EIYP Sbjct: 260 LLPQAIEESTRWCSSAAGIVRFVEREATI----GGETLAAGTILYLSLIARHYDEEIYPR 315 Query: 404 PLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLS 463 P TF R + N FG G C G A E + + L+L Sbjct: 316 PETFDIHR--------RPVGMLN----------FGGGLHYCVGAPLARMEARVGVSLLLE 357 Query: 464 YF 465 F Sbjct: 358 RF 359 >2RHI-A nrPDB Length = 345 Score = 29.3 bits (64), Expect = 4.4, Method: Compositional matrix adjust. Identities = 10/38 (26%), Positives = 22/38 (57%) Query: 398 PEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYM 435 P+ YPDP F +++YL+E G + + ++ + ++ Sbjct: 222 PQDYPDPDNFCWEKYLEETGASAVPTWAFKVRPPHSFL 259 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3SN5-A nrPDB 585 e-167 3B98-A nrPDB 397 e-111 4WMZ-A nrPDB 395 e-110 5JLC-A nrPDB 394 e-110 2IAG-A nrPDB 382 e-106 2WX2-A nrPDB 372 e-103 5FSA-A nrPDB 367 e-102 3L4D-A nrPDB 365 e-101 6CR2-A nrPDB 363 e-101 2X2N-A nrPDB 351 3e-97 3JUS-A nrPDB 324 4e-89 6AYB-A nrPDB 305 2e-83 2VE3-A nrPDB 289 2e-78 3EL3-A nrPDB 284 6e-77 5YLW-A nrPDB 279 1e-75 2NNH-A nrPDB 263 2e-70 6B82-A nrPDB 260 7e-70 2W0A-A nrPDB 258 4e-69 5E0E-A nrPDB 257 7e-69 5W0C-A nrPDB 256 2e-68 5E58-A nrPDB 255 3e-68 4GQS-A nrPDB 254 1e-67 4H1N-A nrPDB 253 2e-67 6DA2-A nrPDB 252 4e-67 3IBD-A nrPDB 250 1e-66 1N6B-A nrPDB 248 4e-66 3E6I-A nrPDB 244 7e-65 5VEU-A nrPDB 241 7e-64 4R1Z-A nrPDB 228 3e-60 4R20-A nrPDB 226 2e-59 5UYS-A nrPDB 215 3e-56 2HI4-A nrPDB 208 5e-54 6C94-A nrPDB 205 4e-53 3MDV-A nrPDB 202 2e-52 5VBU-A nrPDB 196 2e-50 3K9V-A nrPDB 187 7e-48 3QZ1-A nrPDB 187 1e-47 3MZS-A nrPDB 181 6e-46 4KPA-A nrPDB 172 3e-43 3N9Z-A nrPDB 167 1e-41 3S79-A nrPDB 159 3e-39 4ZGX-A nrPDB 153 2e-37 6M7X-A nrPDB 152 3e-37 3DBM-A nrPDB 106 2e-23 Sequences not found previously or not previously below threshold: 2PG7-A nrPDB 233 2e-61 3DL9-A nrPDB 208 4e-54 6DWN-A nrPDB 207 7e-54 3TBG-A nrPDB 197 1e-50 6IQ5-A nrPDB 177 1e-44 3NC3-A nrPDB 124 1e-28 2VZM-A nrPDB 104 1e-22 2RCM-A nrPDB 104 1e-22 1WIY-A nrPDB 103 2e-22 3EJB-B nrPDB 103 2e-22 6FYJ-A nrPDB 99 4e-21 2ZQJ-A nrPDB 97 2e-20 5L94-A nrPDB 97 2e-20 5CJE-A nrPDB 95 9e-20 4YT3-A nrPDB 94 2e-19 5YHJ-A nrPDB 93 3e-19 6HQG-A nrPDB 92 6e-19 4WPZ-A nrPDB 92 7e-19 5XNT-A nrPDB 91 1e-18 4UBS-A nrPDB 90 2e-18 5VWS-A nrPDB 90 2e-18 5IT1-A nrPDB 89 4e-18 2Y5N-A nrPDB 89 4e-18 4JBT-A nrPDB 88 1e-17 4GGV-A nrPDB 88 1e-17 4RM4-A nrPDB 87 1e-17 3R9C-A nrPDB 87 1e-17 2WIO-A nrPDB 87 1e-17 2ZBZ-A nrPDB 87 2e-17 5XJN-A nrPDB 87 2e-17 5GWE-A nrPDB 87 2e-17 5OFQ-A nrPDB 87 2e-17 1ODO-A nrPDB 86 3e-17 1CPT-A nrPDB 86 4e-17 2Z36-A nrPDB 85 5e-17 6GMF-A nrPDB 85 6e-17 3ABA-A nrPDB 85 6e-17 6DCD-A nrPDB 84 1e-16 3ABB-A nrPDB 83 2e-16 3RWL-A nrPDB 83 4e-16 3TYW-A nrPDB 82 5e-16 5FOI-A nrPDB 82 5e-16 6GK6-A nrPDB 82 7e-16 5YSW-A nrPDB 81 9e-16 6F0B-A nrPDB 81 1e-15 1EHE-A nrPDB 81 1e-15 5Y1I-A nrPDB 81 1e-15 1Q5D-A nrPDB 81 1e-15 5HDI-A nrPDB 81 1e-15 6B11-A nrPDB 80 2e-15 5LIE-A nrPDB 80 2e-15 5EX6-C nrPDB 80 2e-15 1GWI-A nrPDB 80 3e-15 1Z8P-A nrPDB 80 3e-15 5HIW-A nrPDB 80 3e-15 5Z9I-A nrPDB 79 4e-15 4TRI-A nrPDB 79 5e-15 3AWQ-A nrPDB 79 5e-15 1F4U-A nrPDB 79 6e-15 6A7J-A nrPDB 79 6e-15 3P3Z-A nrPDB 79 6e-15 1UE8-A nrPDB 78 1e-14 6A7I-A nrPDB 78 1e-14 6G5O-A nrPDB 77 2e-14 5M0P-A nrPDB 77 2e-14 5FYF-A nrPDB 77 2e-14 1UED-A nrPDB 76 2e-14 4OQR-A nrPDB 76 4e-14 1LG9-A nrPDB 76 4e-14 6HQD-A nrPDB 76 4e-14 2XKR-A nrPDB 76 5e-14 5L1U-A nrPDB 76 5e-14 3MGX-A nrPDB 75 5e-14 3WVS-A nrPDB 75 6e-14 4OQS-A nrPDB 75 7e-14 3TKT-A nrPDB 75 9e-14 2WIY-A nrPDB 75 9e-14 4YZR-A nrPDB 74 2e-13 3A50-A nrPDB 73 2e-13 4Z5P-A nrPDB 73 2e-13 5XW2-A nrPDB 73 3e-13 4MM0-A nrPDB 73 3e-13 3OFT-A nrPDB 72 5e-13 2RFC-A nrPDB 71 8e-13 4XE3-A nrPDB 70 2e-12 6FSH-A nrPDB 70 3e-12 3BUJ-A nrPDB 70 3e-12 3A1L-A nrPDB 69 4e-12 5NWS-A nrPDB 69 5e-12 3IVY-A nrPDB 68 8e-12 4Z5Q-A nrPDB 68 1e-11 4TX3-A nrPDB 67 1e-11 6GII-A nrPDB 67 2e-11 3OO3-A nrPDB 67 2e-11 5DQN-A nrPDB 67 2e-11 2FR7-A nrPDB 66 2e-11 5LIV-A nrPDB 66 2e-11 6HQW-A nrPDB 66 3e-11 6F88-A nrPDB 65 6e-11 5DE9-A nrPDB 65 7e-11 5KYO-A nrPDB 65 1e-10 4DO1-A nrPDB 65 1e-10 6M7L-A nrPDB 64 2e-10 5OMS-A nrPDB 63 3e-10 2WM5-A nrPDB 63 4e-10 6G71-A nrPDB 62 5e-10 2X9P-A nrPDB 62 6e-10 6CVC-A nrPDB 61 1e-09 3NV6-A nrPDB 61 1e-09 5HH3-A nrPDB 61 2e-09 5H1Z-A nrPDB 60 2e-09 4FB2-A nrPDB 59 4e-09 5D3U-A nrPDB 59 4e-09 2QBO-A nrPDB 59 4e-09 4C9K-A nrPDB 58 1e-08 4PWV-A nrPDB 57 2e-08 3WEC-A nrPDB 57 2e-08 2IJ7-A nrPDB 55 6e-08 5EX8-A nrPDB 55 7e-08 2NZA-A nrPDB 54 2e-07 6BLD-A nrPDB 54 2e-07 2UUQ-A nrPDB 48 7e-06 2YJN-B nrPDB 39 0.004 3JCU-S nrPDB 35 0.091 5MDX-S nrPDB 35 0.097 5L9W-B nrPDB 32 0.80 4YXC-B nrPDB 31 0.87 4YXB-D nrPDB 31 0.87 1T4B-A nrPDB 31 1.5 5C8J-I nrPDB 31 1.9 4BWI-A nrPDB 30 2.1 4CX7-A nrPDB 30 2.6 5W7L-A nrPDB 30 3.2 1CJM-A nrPDB 28 7.3 >3SN5-A nrPDB Length = 491 Score = 585 bits (1508), Expect = e-167, Method: Composition-based stats. Identities = 478/481 (99%), Positives = 478/481 (99%) Query: 23 GIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNP 82 RRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNP Sbjct: 6 SSRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNP 65 Query: 83 LSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLT 142 LSYHKVLCHGKYFDWKKFHFA SAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLT Sbjct: 66 LSYHKVLCHGKYFDWKKFHFALSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLT 125 Query: 143 ESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHI 202 ESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHI Sbjct: 126 ESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHI 185 Query: 203 LNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMF 262 LNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMF Sbjct: 186 LNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMF 245 Query: 263 LNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENA 322 LNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENA Sbjct: 246 LNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENA 305 Query: 323 GQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIR 382 GQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIR Sbjct: 306 GQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIR 365 Query: 383 KDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGAT 442 KDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGAT Sbjct: 366 KDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGAT 425 Query: 443 ICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFK 502 ICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFK Sbjct: 426 ICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFK 485 Query: 503 H 503 H Sbjct: 486 H 486 >3B98-A nrPDB Length = 475 Score = 397 bits (1020), Expect = e-111, Method: Composition-based stats. Identities = 155/487 (31%), Positives = 257/487 (52%), Gaps = 28/487 (5%) Query: 20 LILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFI 79 ++ G R R+ EPPL+ G+IP+LG AL+FG + +FL + KHG +FT + G Y+ + Sbjct: 8 VLYGRRTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVL 67 Query: 80 TNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALN 139 + Y VL D + + F I P +E QG +L Sbjct: 68 LDSNCYDAVLSDVASLDQTSYAQVLMKRIFN--MILPSHNPESEKKRAEM--HFQGASLT 123 Query: 140 SLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQK 199 L+ SM NL R++ P KT+ W +G+++ CY ++F+ GYLT+FG + + Sbjct: 124 QLSNSMQNNL-RLLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGYLTVFGAE----NNNS 178 Query: 200 AHILNNLDNFKQFDKVFPALV-AGLPIHMFRTAHNAREKLAESLRHENLQKR-ESISELI 257 A + + F++FDK+ P L + + A AREKL + L L ++ S L Sbjct: 179 AALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTPSGLDRKPREQSWLG 238 Query: 258 SLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKR 317 S L D D + + L+ LW +Q N PA FW + ++ +PEA++A EE++ Sbjct: 239 SYVKQLQDEG--IDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQ- 295 Query: 318 TLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDG 377 G+ + LE + PV DS++ E+LRL++A+L R +D + L +G Sbjct: 296 ----GGKHLRLE--------ERQKNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNG 343 Query: 378 -SYNIRKDDIIALYPQLM-HLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYM 435 Y++R+ D + ++P + +DP+I+ P F++DR+L+ + K F+ NG ++KY + Sbjct: 344 QEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPSV 403 Query: 436 PFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDI 495 P+G+ +CPGR FA+H IK+ + +L+ F++EL + A P +D SR G GIL P D+ Sbjct: 404 PWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDL 463 Query: 496 EFKYKFK 502 E +Y+ + Sbjct: 464 EIRYRIR 470 >4WMZ-A nrPDB Length = 539 Score = 395 bits (1014), Expect = e-110, Method: Composition-based stats. Identities = 108/494 (21%), Positives = 201/494 (40%), Gaps = 42/494 (8%) Query: 18 LWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVH 77 +W +L R+ PPL IP++G A+ +G P EF Q+K+G +F+ L+G+ + Sbjct: 44 VWQLLYSLRKD--RPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMT 101 Query: 78 FITNPLSYHKVLCHGKYFD--WKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIK-TLQ 134 P H+ + + K D + + + FG I N+ F+K L Sbjct: 102 VYLGPKG-HEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDC-PNSRLMEQKKFVKGALT 159 Query: 135 GHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLT- 193 A S + E + + R + T + + ++ G+++ Sbjct: 160 KEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRA 219 Query: 194 RRDTQKAHILNNLD-NFKQFDKVFPALVAGLPIHMFRTAHNAREK--------LAESLRH 244 + DT A++ ++LD F + VFP LP+ +R +A++ + E ++ Sbjct: 220 KLDTDFAYLYSDLDKGFTPINFVFP----NLPLEHYRKRDHAQKAISGTYMSLIKERRKN 275 Query: 245 ENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRN 304 ++Q R+ I L+ + + T D E A + VL Q + + W L + Sbjct: 276 NDIQDRDLIDSLMKNSTYKDGVKMT--DQEIANLLIGVLMGGQHTSAATSAWILLHLAER 333 Query: 305 PEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI- 363 P+ + EE R L+ ++ L+ L ++P+L+ IKE+LR+ ++ Sbjct: 334 PDVQQELYEEQMRVLDGGKKE---------LTYDLLQEMPLLNQTIKETLRMHHPLHSLF 384 Query: 364 RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKT---- 419 R +D +H+ + SY I + + P HL E +P+ F R+ +++ + Sbjct: 385 RKVMKD--MHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVG 442 Query: 420 ---KTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKC 476 F + Y+PFG G C G FA ++ + + + + EG+ Sbjct: 443 EEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVP 502 Query: 477 PPLDQSRAGLGILP 490 PP S L P Sbjct: 503 PPDFTSMVTLPTGP 516 >5JLC-A nrPDB Length = 515 Score = 394 bits (1011), Expect = e-110, Method: Composition-based stats. Identities = 112/511 (21%), Positives = 211/511 (41%), Gaps = 54/511 (10%) Query: 19 WLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHF 78 W +L R+ PPL IP++G A+ +G P EF Q+K+G +F+ L+G+ + Sbjct: 27 WQLLYSLRKD--RPPLVFYWIPWVGSAIPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTV 84 Query: 79 ITNPLSYHKVLCHGKYFD--WKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIK-TLQG 135 P H+ + + K D + + + FG I N F+K L Sbjct: 85 YLGPKG-HEFIFNAKLADVSAEAAYSHLTTPVFGKGVIYDC-PNHRLMEQKKFVKGALTK 142 Query: 136 HALNSLTESMMENLQRIMRPPVSSN-SKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLT- 193 A + E + + R + ++ + + + M S + ++ G+++ Sbjct: 143 EAFVRYVPLIAEEIYKYFRNSKNFKINENNSGIVDVMVSQP-EMTIFTASRSLLGKEMRD 201 Query: 194 RRDTQKAHILNNLD-NFKQFDKVFPALVAGLPIHMFRTAHNAREK--------LAESLRH 244 + DT A++ ++LD F + VFP LP+ +R +A++ + E Sbjct: 202 KLDTDFAYLYSDLDKGFTPINFVFP----NLPLEHYRKRDHAQQAISGTYMSLIKERREK 257 Query: 245 ENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRN 304 ++Q R+ I EL+ + + T T D E A + VL Q + + W L + Sbjct: 258 NDIQNRDLIDELMKNSTYKDGTKMT--DQEIANLLIGVLMGGQHTSAATSAWCLLHLAER 315 Query: 305 PEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI- 363 P+ + +E R L N ++ L+ +L ++P+L+ +IKE+LRL ++ Sbjct: 316 PDVQEELYQEQMRVLNNDTKE---------LTYDDLQNMPLLNQMIKETLRLHHPLHSLF 366 Query: 364 RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTF 423 R D + + + SY + +D + + P HL E +P P F R+ +G ++ Sbjct: 367 RKVMRD--VAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRW---DGDAASSS 421 Query: 424 YCNGLKLKYY-----------YMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEG 472 G ++ Y Y+PFG G C G LFA ++ + + + + Sbjct: 422 AAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTE 481 Query: 473 QAKCPPLDQSRAGLGILPPLNDIEFKYKFKH 503 PP D + + P + ++ +H Sbjct: 482 GETVPPSDFTSM---VTLPTAPAKIYWEKRH 509 >2IAG-A nrPDB Length = 482 Score = 382 bits (980), Expect = e-106, Method: Composition-based stats. Identities = 161/487 (33%), Positives = 252/487 (51%), Gaps = 19/487 (3%) Query: 25 RRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLS 84 R R+ GEPPL+ G IP+LG AL FG + FL + KHG +FT + G+YV + +P S Sbjct: 1 RTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHS 60 Query: 85 YHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIK-TLQGHALNSLTE 143 Y V+ + + F A R D + + + +K TL L +LTE Sbjct: 61 YDAVVWEPR----TRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTE 116 Query: 144 SMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFG-----RDLTRRDTQ 198 +M NL ++ + + W G+ F Y + AGYLT++G R + Sbjct: 117 AMYTNLHAVLL--GDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQD 174 Query: 199 KAHILNNLDNFKQFDKVFPALVAG-LPIHMFRTAHNAREKLAESLRHENLQKRESISELI 257 + H + F+Q D++ P L G L + + + +L + L L +R S+ + Sbjct: 175 RVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWL 234 Query: 258 SLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKR 317 + + + + +A+ ++ LWA+Q N PA FW L +++NPEA+ A E++ Sbjct: 235 ESYLLHLEEMG-VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELES 293 Query: 318 TLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDG 377 L A Q VS L Q L+ PVLDS++ ESLRL++A R D + + DG Sbjct: 294 ILWQAEQPVS---QTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADG 350 Query: 378 -SYNIRKDDIIALYPQLM-HLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYM 435 +N+R+ D + L+P L DPEIY DP FKY+R+L+ +G K FY +G +LK Y M Sbjct: 351 REFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNM 410 Query: 436 PFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDI 495 P+G+G C GR +A++ IKQF+ L+L + +LELI + P D SR G G++ P +D+ Sbjct: 411 PWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDV 470 Query: 496 EFKYKFK 502 +Y+ + Sbjct: 471 PVRYRIR 477 >2WX2-A nrPDB Length = 473 Score = 372 bits (955), Expect = e-103, Method: Composition-based stats. Identities = 95/494 (19%), Positives = 182/494 (36%), Gaps = 54/494 (10%) Query: 23 GIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRK-HGHVFTCKLMGKYVHFITN 81 + +PP+ +P+LG +QFG NPLEF++ +R VFT + G+ V + + Sbjct: 9 SFNTTRPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGD 68 Query: 82 PLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSL 141 P + + + + FG + + L + Sbjct: 69 PHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNF 128 Query: 142 TESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQ--K 199 ++ +++ M + + + C ++ +FG DL +R Sbjct: 129 VPAIQHEVRKFM-----AENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHF 183 Query: 200 AHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESL-------RHENLQKRES 252 A +L+ +++ VF + LP+ AR +L + L E K + Sbjct: 184 AQLLSKMESSLIPAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNN 243 Query: 253 ISELI-SLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMI--RNPEAMK 309 S+L+ L + + E + ++A Q + T WS+ ++ +N + + Sbjct: 244 TSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLD 303 Query: 310 AATEEVKRTLENAGQKVSLEGNPICLSQAE-LNDLPVLDSIIKESLRLSSASLNIRTAKE 368 +E+ P L+ ++++P + ++ES+R L Sbjct: 304 KLHKEIDE-------------FPAQLNYDNVMDEMPFAERCVRESIRRDPPLLM---VMR 347 Query: 369 DFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGL 428 ++ GSY + K DIIA P L H D E +P+P + +R Sbjct: 348 MVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPER---------------DE 392 Query: 429 KLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGI 488 K+ ++ FG+G C G+ FA+ ++K L ++ +L+ + P G Sbjct: 393 KVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVG--- 449 Query: 489 LPPLNDIEFKYKFK 502 P LN KY K Sbjct: 450 -PTLNQCLVKYTRK 462 >5FSA-A nrPDB Length = 490 Score = 367 bits (941), Expect = e-102, Method: Composition-based stats. Identities = 103/488 (21%), Positives = 185/488 (37%), Gaps = 46/488 (9%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCH 91 PPL IP+ G A +G P EF + ++K+G VF+ L+GK + P H+ + + Sbjct: 6 PPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKG-HEFVFN 64 Query: 92 GKYFD--WKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIK-TLQGHALNSLTESMMEN 148 K D ++ + + FG I N+ F K L + + E Sbjct: 65 AKLSDVSAEEAYKHLTTPVFGTGVIYDC-PNSRLMEQKKFAKFALTTDSFKRYVPKIREE 123 Query: 149 LQRIMRPPVSSNSKTAAWVTEGMYSFCY---RVMFEAGYLTIFGRDLTR-RDTQKAHILN 204 + + V+ S T G+ + + ++FG ++ R D A + + Sbjct: 124 I---LNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYS 180 Query: 205 NLD-NFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFL 263 +LD F + VFP LP+ + A++K++ + E ++ R ++ R + Sbjct: 181 DLDKGFTPINFVFP----NLPLPHYWRRDAAQKKISATYMKE-IKLRRERGDIDPNRDLI 235 Query: 264 NDTL--------STFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEV 315 + L D E A + +L Q + + W L + P +EV Sbjct: 236 DSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEV 295 Query: 316 KRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLE 375 L+ G G+ L+ +L LP +++ IKE+LR+ +I K L + Sbjct: 296 VELLKEKG------GDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFR-KVTNPLRIP 348 Query: 376 DGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYY-- 433 + +Y + K + + P H + +P F R+ K + + + ++ Y Sbjct: 349 ETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFG 408 Query: 434 ---------YMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRA 484 Y+PFG G C G FA ++ L + + L K P D S Sbjct: 409 KVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV--YNLRWTIDGYKVPDPDYSSM 466 Query: 485 GLGILPPL 492 + P Sbjct: 467 VVLPTEPA 474 >3L4D-A nrPDB Length = 453 Score = 365 bits (936), Expect = e-101, Method: Composition-based stats. Identities = 91/481 (18%), Positives = 181/481 (37%), Gaps = 53/481 (11%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCH 91 PP+ +G P++G +QFG +PL F+ ++K+G +FT + G + + + + K Sbjct: 5 PPVVHGTTPFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSKFFTP 64 Query: 92 GKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQR 151 + ++ FG + + L + S+ +++ Sbjct: 65 RNEILSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTVAKFQNFAPSIQHEVRK 124 Query: 152 IMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRR--DTQKAHILNNLDNF 209 M+ + + + C ++ +FG DL +R Q A +L +++ Sbjct: 125 FMKANWNKDE-----GEINILDDCSAMIINTACQCLFGEDLRKRLDARQFAQLLAKMESC 179 Query: 210 KQFDKVFPALVAGLPIHMFRTAHNAREKLAESL-------RHENLQKRESISELIS-LRM 261 VF + LP+ +AR +L + L E QK + S+L++ L Sbjct: 180 LIPAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNTSDLLAGLLG 239 Query: 262 FLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMI--RNPEAMKAATEEVKRTL 319 + + E + ++A Q + T WSL ++ RN + +E+ Sbjct: 240 AVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEIDE-- 297 Query: 320 ENAGQKVSLEGNPICLSQAE-LNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGS 378 P L+ + ++P + +ES+R + + ++ G Sbjct: 298 -----------FPAQLNYDNVMEEMPFAEQCARESIRRDPPLVML---MRKVLKPVQVGK 343 Query: 379 YNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFG 438 Y + + DIIA P L H D E +P+P + +R N + + FG Sbjct: 344 YVVPEGDIIACSPLLSHQDEEAFPNPREWNPER--------------NMKLVDGAFCGFG 389 Query: 439 SGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFK 498 +G C G F + ++K L +L ++ EL+ P + + + + P + K Sbjct: 390 AGVHKCIGEKFGLLQVKTVLATVLRDYDFELLG-----PLPEPNYHTMVVGPTASQCRVK 444 Query: 499 Y 499 Y Sbjct: 445 Y 445 >6CR2-A nrPDB Length = 477 Score = 363 bits (932), Expect = e-101, Method: Composition-based stats. Identities = 98/493 (19%), Positives = 192/493 (38%), Gaps = 44/493 (8%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCH 91 PP+ P++G + +G +P +F + K+G +FT L+GK + + Sbjct: 6 PPVVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGND-FILN 64 Query: 92 GKYFD--WKKFHFATSAKAFG-HRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMEN 148 GK D ++ + + FG H D + E L AL S + + Sbjct: 65 GKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLME-QKKFVKYGLTSDALRSYVPLITDE 123 Query: 149 LQRIMRPPVSSNSKTAAWVTEGMYSFCY---RVMFEAGYLTIFGRDLT-RRDTQKAHILN 204 ++ ++ + A +G++ C + ++ G+++ + D+ A + + Sbjct: 124 VESFVK------NSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEVRSKFDSTFAELYH 177 Query: 205 NLD-NFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESL------RHENLQKRESISELI 257 NLD F + + P P+ R A+ KL E+ R + K++S + Sbjct: 178 NLDMGFAPINFMLPWA----PLPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMVW 233 Query: 258 SLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKR 317 +L + + D E A + +L A Q ++ W + ++ P+ M+ +E R Sbjct: 234 NLMSCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIR 293 Query: 318 TLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDG 377 L + + L+ L L + +IKE+LRL + +I A ++ + ++ Sbjct: 294 VLGS---------DLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKN-PMAVDGT 343 Query: 378 SYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYL-------DENGKTKTTFYCNGLKL 430 SY I + P + E +P+PL + R+ +++ K + Sbjct: 344 SYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGT 403 Query: 431 KYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILP 490 Y+PFG+G C G FA ++ +++ F + G P D S L Sbjct: 404 NSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVDGIPDTDYSSLFSKPLG 463 Query: 491 PLNDIEFKYKFKH 503 +EF+ + H Sbjct: 464 RSF-VEFEKRHHH 475 >2X2N-A nrPDB Length = 475 Score = 351 bits (901), Expect = 3e-97, Method: Composition-based stats. Identities = 95/490 (19%), Positives = 187/490 (38%), Gaps = 56/490 (11%) Query: 28 QTGEPPLENGLIPYLGCALQFGANPLEFLRANQRK-HGHVFTCKLMGKYVHFITNPLSYH 86 + +PP+ +P LG +QFG +PL F++ +R+ +FT ++GK V + +P + Sbjct: 14 RPTDPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHS 73 Query: 87 KVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMM 146 + + ++ FG + + L + ++ Sbjct: 74 RFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQ 133 Query: 147 ENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRR--DTQKAHILN 204 +++ M + + C ++ +FG DL +R + A +L Sbjct: 134 HEVRKFMAANWDKDE-----GEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLLA 188 Query: 205 NLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRH-------ENLQKRESISELI 257 +++ VF ++ LP+ H AR +L + L + K S S+L+ Sbjct: 189 KMESSLIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKAAAVNKDSSTSDLL 248 Query: 258 S-LRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIR--NPEAMKAATEE 314 S L + + E + ++A Q + T WS+ ++ N + ++A +E Sbjct: 249 SGLLSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKE 308 Query: 315 VKRTLENAGQKVSLEGNPICLSQAE-LNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTL 372 + E P L+ ++++P + +ES+R L + R D + Sbjct: 309 I-------------EEFPAQLNYNNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKV 355 Query: 373 HLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKY 432 GSY + K DIIA P L H D E +P+P + +R K++ Sbjct: 356 ----GSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPER---------------DEKVEG 396 Query: 433 YYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPL 492 ++ FG+G C G+ F + ++K L ++ +L+ + P G P Sbjct: 397 AFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPDPDYHTMVVG----PTA 452 Query: 493 NDIEFKYKFK 502 + KY + Sbjct: 453 SQCRVKYIRR 462 >3JUS-A nrPDB Length = 461 Score = 324 bits (831), Expect = 4e-89, Method: Composition-based stats. Identities = 107/483 (22%), Positives = 185/483 (38%), Gaps = 54/483 (11%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGK-YVHFITNPLSYHKVLC 90 PP IP+LG A+ FG +P+EFL K+G VF+ ++GK + + + + + Sbjct: 13 PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNS 72 Query: 91 HGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFI--KTLQGHALNSLTESMMEN 148 + + + + + FG G + N F+ K + LN + Sbjct: 73 KNEDLNAEDVYSRLTTPVFGK-------GVAYDVPNPVFLEQKKMLKSGLN-----IAHF 120 Query: 149 LQRIMRPPVSSNSKTAAWVTEGMYSF---CYRVMFEAGYLTIFGRDLTRRDTQK-AHILN 204 Q + + +W G + ++ + G+++ + +K A + Sbjct: 121 KQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYA 180 Query: 205 NLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLN 264 +LD F L LP+ FR A ++ + ++R+S ++ + L Sbjct: 181 DLDG--GFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLL 238 Query: 265 D----TLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLE 320 D D E A + +L A Q + + W F + R+ K E K Sbjct: 239 DATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCG 298 Query: 321 NAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSA-SLNIRTAKEDFTLHLEDGSY 379 N L+ +L DL +LD IKE+LRL + +R A+ T+ Y Sbjct: 299 E---------NLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTV----AGY 345 Query: 380 NIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGS 439 I + + P + + + + L F DRYL +N + K+ Y+PFG+ Sbjct: 346 TIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGE---------KFAYVPFGA 396 Query: 440 GATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKY 499 G C G FA +IK ML +E +LI+G I P N + +Y Sbjct: 397 GRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGY-----FPTVNYTTMIHTPENPV-IRY 450 Query: 500 KFK 502 K + Sbjct: 451 KRR 453 >6AYB-A nrPDB Length = 466 Score = 305 bits (781), Expect = 2e-83, Method: Composition-based stats. Identities = 89/481 (18%), Positives = 180/481 (37%), Gaps = 45/481 (9%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCH 91 PP LIPY+G + F NP++F+ N +K+G VFT ++GK + F+ +P Sbjct: 12 PPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLNHPKILDTFFKA 71 Query: 92 GKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFI-KTLQGHALNSLTESMMENLQ 150 + + FG + D F+ L + + + Sbjct: 72 TDNELSLRDVYRFMRPVFGTGVVYDADSTERMMEQVKFVSSGLTTARFRVFVDIFEDEIA 131 Query: 151 RIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQK--AHILNNL-D 207 ++ T + ++ + G ++ + ++K + +++ D Sbjct: 132 HKVKELGPE-------GTVDVAELMADLIIFTASRCLLGDEVRQYLSEKNLGKLYHDIDD 184 Query: 208 NFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISE------LISLRM 261 +P+L A + ++L + R E+ + E + + + L Sbjct: 185 GISPLSFFYPSLPAPKRDKARKAVGEIFQELLDKRREEHKKHPERLLDESKMDVVDHLLT 244 Query: 262 FLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLEN 321 D+ + + L+A Q + + W+L +I N + ++ +E + + Sbjct: 245 QKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEEIM-- 302 Query: 322 AGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNI 381 G+ L ++ + L++ +KE+LR+ + I E Y I Sbjct: 303 --------GSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARK---PRECEQYII 351 Query: 382 RKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGA 441 K +I+ + P + + Y +P F +R + K KY +PFG+G Sbjct: 352 PKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEK---------FKYGAVPFGAGR 402 Query: 442 TICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKF 501 C G FA+ ++K + ++L YF++E I K P + +G PP +YK Sbjct: 403 HKCIGENFALLQVKSIISILLRYFDMEYI---GKIPDPSYTSLVVGPSPPT---RMRYKL 456 Query: 502 K 502 + Sbjct: 457 R 457 >2VE3-A nrPDB Length = 444 Score = 289 bits (740), Expect = 2e-78, Method: Composition-based stats. Identities = 91/451 (20%), Positives = 176/451 (39%), Gaps = 51/451 (11%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCH 91 PP + GL P+LG L F N +F + Q++ G +F +L GK V FI+ L+ ++ L Sbjct: 14 PPGDFGL-PWLGETLNF-LNDGDFGKKRQQQFGPIFKTRLFGKNVIFISGALA-NRFLFT 70 Query: 92 GKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQR 151 + ++ ++ G ++ G + + L+S M +Q Sbjct: 71 KEQETFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLDSYLPKMDGIVQG 130 Query: 152 IMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQ 211 + +N W Y R+ F+ G + +Q + + + Q Sbjct: 131 YLEQWGKANE--VIW-----YPQLRRMTFDVAATLFMGEKV----SQNPQLFPWFETYIQ 179 Query: 212 FDKVFPALVAGLPIHMFRTAHNAR-------EKLAESLRHENLQKRESISELISLRMFLN 264 +F +L LP +F + AR EK+ ++ + + + +++ L++ R + Sbjct: 180 --GLF-SLPIPLPNTLFGKSQRARALLLAELEKIIKARQQQPPSEEDALGILLAAR---D 233 Query: 265 DTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQ 324 D E L++L+A A + ++ + + +E + + Sbjct: 234 DNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLSQE- 292 Query: 325 KVSLEGNPICLSQAELNDLPVLDSIIKESLRL-SSASLNIRTAKEDFTLHLEDGSYNIRK 383 L+ L +P LD +++E LRL R +D + ++ K Sbjct: 293 ----------LTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDC----QFQGFHFPK 338 Query: 384 DDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATI 443 +++ H DP++YPDP F +R+ + T + ++PFG G Sbjct: 339 GWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPP--------FAHVPFGGGLRE 390 Query: 444 CPGRLFAIHEIKQFLILMLSYFELELIEGQA 474 C G+ FA E+K F ++ F+ L+ GQ Sbjct: 391 CLGKEFARLEMKLFATRLIQQFDWTLLPGQN 421 >3EL3-A nrPDB Length = 467 Score = 284 bits (726), Expect = 6e-77, Method: Composition-based stats. Identities = 93/484 (19%), Positives = 163/484 (33%), Gaps = 57/484 (11%) Query: 31 EPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLC 90 EPP+ G +P LG + +PL F+ + R HG V KL K V+ +TNP + Sbjct: 23 EPPVAGGGVPLLGHGWRLARDPLAFM-SQLRDHGDVVRIKLGPKTVYAVTNPELTGALAL 81 Query: 91 HGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQ 150 + Y + + G + +G T + A+ + M E Sbjct: 82 NPDYHIAGPL-WESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAH 140 Query: 151 RIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIF-GRDLTRRDTQKAHILNNLDNF 209 + T S +RV + G+ + R + L + Sbjct: 141 ALTERWQP-------GKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATV--- 190 Query: 210 KQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISE-----------LIS 258 F ++ +V L ++R A + ++L +L E I+E L + Sbjct: 191 --FRGMYRRMVVPL-GPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTA 247 Query: 259 LRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRT 318 L +D + E + +L W L + +PE +EV+ Sbjct: 248 LLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAV 307 Query: 319 LENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGS 378 ++ ++ L ++I E++RL A + E G Sbjct: 308 TGG-----------RPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRR---AVAESELGG 353 Query: 379 YNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFG 438 Y I I P + DP+ Y D L F DR+L E KY PF Sbjct: 354 YRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVP---------KYAMKPFS 404 Query: 439 SGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFK 498 +G CP F++ ++ + + + E + G D R G+ + P +D+ + Sbjct: 405 AGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSN-----DAVRVGITLRP--HDLLVR 457 Query: 499 YKFK 502 + Sbjct: 458 PVAR 461 >5YLW-A nrPDB Length = 495 Score = 279 bits (714), Expect = 1e-75, Method: Composition-based stats. Identities = 100/509 (19%), Positives = 177/509 (34%), Gaps = 67/509 (13%) Query: 21 ILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFIT 80 L RRR+ P P +G LQ GANP + +++G + + L Y ++ Sbjct: 19 FLSFRRRRNLPP--GPFPYPIVGNMLQLGANPHQVFAKLSKRYGPLMSIHLGSLYTVIVS 76 Query: 81 NPLSYHKVLC-HGKYFDWKKFHFATSAKAFGHRSIDPMDGNT------------TENIND 127 +P ++L HG+ F + A + A H I + ++ Sbjct: 77 SPEMAKEILHRHGQVFSGRTI--AQAVHACDHDKISMGFLPVASEWRDMRKICKEQMFSN 134 Query: 128 TFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTI 187 ++ QG L + +++++Q+ S+S A + E + +M T+ Sbjct: 135 QSMEASQGLRRQKL-QQLLDHVQK------CSDSGRAVDIREAAFITTLNLM----SATL 183 Query: 188 FGRDLTRRDTQKA-------HILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKL-- 238 F T D++ + + F FP L P + R A KL Sbjct: 184 FSSQATEFDSKATMEFKEIIEGVATIVGVPNFADYFPILRPFDPQGVKRRADVFFGKLLA 243 Query: 239 -AESLRHENLQKRESISELISLRMFLNDTLSTFDDLE-------KAKTHLVVLWASQANT 290 E +E L+ + + FL + E L + Sbjct: 244 KIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFKLKTHHFTHLMLDLFVGGSDTN 303 Query: 291 IPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSII 350 + W++ +++ NP+ M E+K G+ + ++ + LP L ++I Sbjct: 304 TTSIEWAMSELVMNPDKMARLKAELKSV----------AGDEKIVDESAMPKLPYLQAVI 353 Query: 351 KESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYD 410 KE +R+ + E Y I K I + + DP I+ DP TF + Sbjct: 354 KEVMRIHPPGPLL--LPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTDPETFDPE 411 Query: 411 RYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELI 470 R+LD K Y +PFGSG +CPG A + ++ F+ +L Sbjct: 412 RFLDNKIDFK--------GQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWKLE 463 Query: 471 EGQAKCPPLDQSRAGLGIL--PPLNDIEF 497 + G+ + PL I Sbjct: 464 DDSTAAADHAGELFGVAVRRAVPLRIIPI 492 >2NNH-A nrPDB Length = 476 Score = 263 bits (671), Expect = 2e-70, Method: Composition-based stats. Identities = 93/500 (18%), Positives = 167/500 (33%), Gaps = 43/500 (8%) Query: 22 LGIRRRQTGEPPLENGLIPYLGCALQFG-ANPLEFLRANQRKHGHVFTCKLMGKYVHFIT 80 + + G+ P +P +G LQ + + + +G VFT + Sbjct: 1 MAKKTSSKGKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFH 60 Query: 81 NPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNS 140 + + L + + S + I +G + I + TL+ + Sbjct: 61 GYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGK 120 Query: 141 LTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGR---------- 190 S+ + +Q V KT A + + +F + Sbjct: 121 --RSIEDRVQEEAHCLVEELRKTKASPCDPTF-ILGCAPCNVICSVVFQKRFDYKDQNFL 177 Query: 191 DLTRRDTQKAHILNN-----LDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHE 245 L +R + ILN+ +NF FP + ++ T REK+ E Sbjct: 178 TLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASL 237 Query: 246 NLQKRESISE--LISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIR 303 ++ + LI + ++ S F+ T + A T + L +++ Sbjct: 238 DVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLK 297 Query: 304 NPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI 363 +PE EE+ + G + + +P D+++ E R S L Sbjct: 298 HPEVTAKVQEEIDHVI----------GRHRSPCMQDRSHMPYTDAVVHEIQRYS--DLVP 345 Query: 364 RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTF 423 T + +Y I K I + D + +P+P F +LD+NG K Sbjct: 346 TGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKK-- 403 Query: 424 YCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSR 483 Y+MPF +G IC G A E+ FL +L F L+ ++ ++ Sbjct: 404 -------SDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTK 456 Query: 484 AGLGILPPLNDIEFKYKFKH 503 G+ LPP I F H Sbjct: 457 -GIVSLPPSYQICFIPVHHH 475 >6B82-A nrPDB Length = 509 Score = 260 bits (665), Expect = 7e-70, Method: Composition-based stats. Identities = 93/498 (18%), Positives = 177/498 (35%), Gaps = 54/498 (10%) Query: 29 TGEPPLENGLIPYLGCALQFGAN--PLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYH 86 PP L P +G + ++ P F + Q+K+G +++ + + + N Sbjct: 22 NRSPPSLPSL-PIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHHHAK 80 Query: 87 KVLCH-GKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESM 145 ++L GK F + + D + + F + + AL E Sbjct: 81 EILIKKGKIFAGRP--RTVTTDLLTRDGKDIAFADYSST--WKFHRKMVHGALCMFGEGS 136 Query: 146 MENLQRIMRPPVSSNSKTAAWVTE--GMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHIL 203 + + I R S + R + F R D + +L Sbjct: 137 VSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKRGDAEFESML 196 Query: 204 NNLDNFK------QFDKVFPALV--AGLPIHMFRTAHNAREKLAESLRHENLQ------K 249 +FP L + + R + R+KL + E+ + Sbjct: 197 QYSQGIVDTVAKDSLVDIFPWLQIFPNKDLRILRQCISIRDKLLQKKYEEHKVTYSDNVQ 256 Query: 250 RESISELISLRMFLNDTLSTFDDLEKAKTHLVV-----LWASQANTIPATFWSLFQMIRN 304 R+ + L+ + + S+ D+ + H+++ A T WS+ ++ N Sbjct: 257 RDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVHN 316 Query: 305 PEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSS--ASLN 362 P+ + EE+ + G ++ +LP L++ I E +R+ L Sbjct: 317 PQVQRKIQEELDSKI----------GKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLI 366 Query: 363 IRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTT 422 A +D ++ G Y ++K + + +H D + + +P F R+L+E G Sbjct: 367 PHVALQDSSV----GEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGD---- 418 Query: 423 FYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQS 482 Y+PFG+G +C G A E+ FL +L F LE+ GQ P L Q Sbjct: 419 ---GLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQ-PLPDL-QG 473 Query: 483 RAGLGILPPLNDIEFKYK 500 + G+ + P + K + Sbjct: 474 KFGVVLQPKKFKVVAKVR 491 >2W0A-A nrPDB Length = 455 Score = 258 bits (659), Expect = 4e-69, Method: Composition-based stats. Identities = 93/482 (19%), Positives = 188/482 (39%), Gaps = 52/482 (10%) Query: 33 PLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHG 92 P +G G +F +P+ ++ + + G V T +L GK V ++ + G Sbjct: 7 PRVSGGHDEHGHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAG 66 Query: 93 KYFDWKKFHFATSAKAFGHRSI-DPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQR 151 + + FG + D E +++ L+G + ++ + ++R Sbjct: 67 DDDLDQAKAYPFMTPIFGEAVVFDASPERRKEMLHNA---ALRGEQMKGHAATIEDQVRR 123 Query: 152 IMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRR-DTQKAHILNNLD-NF 209 ++ + + F + + G+ + D + A + + L+ Sbjct: 124 MIADWGEAGE-------IDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGT 176 Query: 210 KQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRH------ENLQKRESISELISLRMFL 263 V P LPI FR AR L + N +S +++ + + + Sbjct: 177 DPLAYVDP----YLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAV 232 Query: 264 NDTLST--FDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLEN 321 T F E + +++A + W+L +++R+ +A A +E+ L Sbjct: 233 KAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDE-LYG 291 Query: 322 AGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYN 380 G+ VS L +P L++++KE+LRL + + R AK +F + + Sbjct: 292 DGRSVSFHA---------LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQ----GHR 338 Query: 381 IRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSG 440 I + D++A P + + PE +PDP F RY + L ++ ++PFG+G Sbjct: 339 IHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQED--------LLNRWTWIPFGAG 390 Query: 441 ATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYK 500 C G FAI +IK ++L +E E+ A+ P ++ ++ +Y+ Sbjct: 391 RHRCVGAAFAIMQIKAIFSVLLREYEFEM----AQPPESYRNDHSKMVVQLAQPAAVRYR 446 Query: 501 FK 502 + Sbjct: 447 RR 448 >5E0E-A nrPDB Length = 463 Score = 257 bits (656), Expect = 7e-69, Method: Composition-based stats. Identities = 78/464 (16%), Positives = 147/464 (31%), Gaps = 46/464 (9%) Query: 56 LRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSID 115 R + K+G VFT L + V + + + L + A F + Sbjct: 27 FRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTIAVVEPIFRGYGVV 86 Query: 116 PMDGNTTENINDTFIKTLQ--GHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYS 173 +G + + + T++ G S+ E + E + ++ S Sbjct: 87 FANGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQGAPL---DPTFLF 143 Query: 174 FCYRVMFEAGYLTIFGRDLTRRDTQKAHIL---------------NNLDNFKQFDKVFPA 218 C + +FG +D Q +L + F F K FP Sbjct: 144 QC--ITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFSGFLKYFPG 201 Query: 219 LVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISE--LISLRMFLNDTLSTFDDLEKA 276 + ++ + + + + + L+ + ++ + FD Sbjct: 202 THRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHTEFDHQNLV 261 Query: 277 KTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLS 336 + L + +A + + M++ P + +E+ + + G+ + Sbjct: 262 ISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVI----------GSHRLPT 311 Query: 337 QAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHL 396 + +P +++I E R S L T Y + K+ + Sbjct: 312 LEDRTKMPYTEAVIYEIQRFS--DLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALH 369 Query: 397 DPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQ 456 DP+ + P TF D +LD NG K +MPF G IC G A +E+ Sbjct: 370 DPQYFEQPDTFNPDHFLDANGALKK---------SEAFMPFSIGKRICLGEGIARNELFL 420 Query: 457 FLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYK 500 F +L F L K L +G G +P I F + Sbjct: 421 FFTTILQNFSLS-SPVAPKDIDLSPKESGFGKVPQTYQICFLAR 463 >5W0C-A nrPDB Length = 477 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 94/493 (19%), Positives = 170/493 (34%), Gaps = 43/493 (8%) Query: 29 TGEPPLENGLIPYLGCALQFG-ANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHK 87 G+ P +P +G LQ G + + L + +G VFT K + + + + Sbjct: 9 RGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKE 68 Query: 88 VLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMME 147 L + F + +A I +G + I + TL+ + S+ + Sbjct: 69 ALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK--RSIED 126 Query: 148 NLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLD 207 +Q R V KT A + + IF + +D Q +++ L+ Sbjct: 127 RVQEEARCLVEELRKTKASPCDPTF-ILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 185 Query: 208 ---------------NFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRES 252 NF FP L ++ EK+ E ++ + Sbjct: 186 ENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQD 245 Query: 253 ISE--LISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKA 310 + L+ + ++ S F T + + A T ++L ++++PE Sbjct: 246 FIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAK 305 Query: 311 ATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDF 370 EE++R + G + + +P D+++ E R L + Sbjct: 306 VQEEIERVI----------GRNRSPCMQDRSHMPYTDAVVHEVQRY--IDLLPTSLPHAV 353 Query: 371 TLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKL 430 T ++ +Y I K I + + D + +P+P F +LDE G K Sbjct: 354 TCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK--------- 404 Query: 431 KYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILP 490 Y+MPF +G IC G A E+ FL +L F L+ + K G +P Sbjct: 405 SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD-PKNLDTTPVVNGFASVP 463 Query: 491 PLNDIEFKYKFKH 503 P + F H Sbjct: 464 PFYQLCFIPIHHH 476 >5E58-A nrPDB Length = 493 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 78/466 (16%), Positives = 148/466 (31%), Gaps = 46/466 (9%) Query: 56 LRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSID 115 + K+G VFT L + V + + + L + A G + Sbjct: 55 FMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTIAVIKPVIGDYGMI 114 Query: 116 PMDGNTTENINDTFIKTLQ--GHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYS 173 +G + + + T++ G S+ + + E Q ++ S Sbjct: 115 FSNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQGAPL---DPTFLF 171 Query: 174 FCYRVMFEAGYLTIFGRDLTRRDTQKAHILN---------------NLDNFKQFDKVFPA 218 C + +FG +D Q +L+ + F F K FP Sbjct: 172 QC--ITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFSGFMKYFPG 229 Query: 219 LVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISE--LISLRMFLNDTLSTFDDLEKA 276 + ++ + + + + + L+ + ++ + F Sbjct: 230 AHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHTEFHHQNLL 289 Query: 277 KTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLS 336 + L + +A T + M++ P + +E+ + + G+ + Sbjct: 290 ISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVI----------GSHRLPT 339 Query: 337 QAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHL 396 + +P D++I E R S L A T Y + K+ + Sbjct: 340 LEDRTKMPYTDAVIHEIQRFS--DLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALH 397 Query: 397 DPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQ 456 DP+ + P TF D +LD NG K +MPF G IC G A +E+ Sbjct: 398 DPQYFEQPGTFNPDHFLDANGALKK---------SEAFMPFSIGKRICLGEGIARNELFL 448 Query: 457 FLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFK 502 F +L F + K L +G+G +P I F + Sbjct: 449 FFTTILQNFSVS-SSVAPKDIDLSPKESGIGKVPQTYQISFLARHH 493 >4GQS-A nrPDB Length = 477 Score = 254 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 95/493 (19%), Positives = 166/493 (33%), Gaps = 43/493 (8%) Query: 29 TGEPPLENGLIPYLGCALQFG-ANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHK 87 G+ P +P +G LQ + + L + +G VFT + + + + Sbjct: 9 RGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKE 68 Query: 88 VLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMME 147 L + HF + +A I +G + I + TL+ + S+ + Sbjct: 69 ALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK--RSIED 126 Query: 148 NLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLD 207 +Q R V KT A + + IF + +D Q +++ L+ Sbjct: 127 RVQEEARCLVEELRKTKASPCDPTF-ILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLN 185 Query: 208 ---------------NFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRES 252 NF FP L ++ + EK+ E ++ Sbjct: 186 ENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRD 245 Query: 253 ISE--LISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKA 310 + LI + + S F T +L A T ++L ++++PE Sbjct: 246 FIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAK 305 Query: 311 ATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDF 370 EE++R + G + +P D+++ E R L + Sbjct: 306 VQEEIERVV----------GRNRSPCMQDRGHMPYTDAVVHEVQRY--IDLIPTSLPHAV 353 Query: 371 TLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKL 430 T ++ +Y I K I + D + +P+P F +LDE G K Sbjct: 354 TCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK--------- 404 Query: 431 KYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILP 490 Y+MPF +G IC G A E+ FL +L F L+ + K G +P Sbjct: 405 SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID-PKDLDTTPVVNGFASVP 463 Query: 491 PLNDIEFKYKFKH 503 P + F H Sbjct: 464 PFYQLCFIPIHHH 476 >4H1N-A nrPDB Length = 479 Score = 253 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 89/497 (17%), Positives = 161/497 (32%), Gaps = 43/497 (8%) Query: 22 LGIRRRQTGEPPLENGLIPYLGCALQFGANPL-EFLRANQRKHGHVFTCKLMGKYVHFIT 80 + + G+ P +P LG LQ L + K+G VFT L + V + Sbjct: 1 MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC 60 Query: 81 NPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNS 140 + + L + A F + +G + + T++ + Sbjct: 61 GTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGMGK 120 Query: 141 LTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKA 200 S+ E +Q R V K+ + + F + + +FG+ +D Sbjct: 121 --RSVEERIQEEARCLVEELRKSKGALLDNTLLF-HSITSNIICSIVFGKRFDYKDPVFL 177 Query: 201 HILN---------------NLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHE 245 +L+ + F F K FP + ++ + + + Sbjct: 178 RLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATL 237 Query: 246 NLQKRESISE--LISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIR 303 + + L+ + +D S F T L + A T + M++ Sbjct: 238 DPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLK 297 Query: 304 NPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI 363 P + +E+++ + G+ + + +P D++I E RL L Sbjct: 298 YPHVTERVQKEIEQVI----------GSHRPPALDDRAKMPYTDAVIHEIQRL--GDLIP 345 Query: 364 RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTF 423 T + Y I K+ + DP + P TF +LD NG Sbjct: 346 FGVPHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANG------ 399 Query: 424 YCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSR 483 LK +MPF G IC G A E+ F +L F + + L Sbjct: 400 ---ALKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSI-ASPVPPEDIDLTPRE 455 Query: 484 AGLGILPPLNDIEFKYK 500 +G+G +PP I F + Sbjct: 456 SGVGNVPPSYQIRFLAR 472 >6DA2-A nrPDB Length = 487 Score = 252 bits (642), Expect = 4e-67, Method: Composition-based stats. Identities = 88/486 (18%), Positives = 166/486 (34%), Gaps = 49/486 (10%) Query: 36 NGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYF 95 +P+LG L + F +K+G V+ + V IT+P VL Y Sbjct: 21 PTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYS 80 Query: 96 DWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRP 155 + F +I + + + T L + + + ++R Sbjct: 81 VFTNRRPFGPVG-FMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRN 139 Query: 156 PVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDT---------QKAHILNNL 206 + + T FG ++ + +K + L Sbjct: 140 LRRE---AETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFL 196 Query: 207 DNFKQFDKVFPALVAGL--------PIHMFRTAHNAREKLAESLRHENLQKRESISELIS 258 D F VFP L+ L P + + +++ ES + + R +L+ Sbjct: 197 DPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMI 256 Query: 259 LRMFLNDTLS--TFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVK 316 +T S DLE ++ ++A T + ++++ +P+ + EE+ Sbjct: 257 DSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEID 316 Query: 317 RTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLED 376 L N + + + LD ++ E+LRL ++ + +E Sbjct: 317 AVLPNKAPP----------TYDTVLQMEYLDMVVNETLRLFPIAMRLERV---CKKDVEI 363 Query: 377 GSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMP 436 I K ++ + +H DP+ + +P F +R+ +N Y Y P Sbjct: 364 NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP---------YIYTP 414 Query: 437 FGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIE 496 FGSG C G FA+ +K LI +L F + + PL S G+L P + Sbjct: 415 FGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPC--KETQIPLKLSLG--GLLQPEKPVV 470 Query: 497 FKYKFK 502 K + + Sbjct: 471 LKVESR 476 >3IBD-A nrPDB Length = 476 Score = 250 bits (638), Expect = 1e-66, Method: Composition-based stats. Identities = 82/470 (17%), Positives = 149/470 (31%), Gaps = 46/470 (9%) Query: 53 LEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHR 112 L+ + K+G VFT L + V + + + L + A F Sbjct: 33 LKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGY 92 Query: 113 SIDPMDGNTTENINDTFIKTLQ--GHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEG 170 + +GN + + + T++ G S+ E + E Q ++ + + Sbjct: 93 GVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIE-----ELRKSKGALMD 147 Query: 171 MYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNL---------------DNFKQFDKV 215 + +FG+ +D + +LN + F F K Sbjct: 148 PTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKH 207 Query: 216 FPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISE--LISLRMFLNDTLSTFDDL 273 FP + ++ + + + + + L+ + ++ S F Sbjct: 208 FPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNAHSEFSHQ 267 Query: 274 EKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPI 333 L + +A T + M++ P + E+++ + G Sbjct: 268 NLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVI----------GPHR 317 Query: 334 CLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQL 393 + +P +++I E R S L T H Y I KD + L Sbjct: 318 PPELHDRAKMPYTEAVIYEIQRFS--DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILST 375 Query: 394 MHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHE 453 DP + P F D +LD NG K T ++PF G IC G A E Sbjct: 376 ALHDPHYFEKPDAFNPDHFLDANGALKKT---------EAFIPFSLGKRICLGEGIARAE 426 Query: 454 IKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKH 503 + F +L F + + L G+G +PP I F + H Sbjct: 427 LFLFFTTILQNFSM-ASPVAPEDIDLTPQECGVGKIPPTYQIRFLPRHHH 475 >1N6B-A nrPDB Length = 473 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 94/497 (18%), Positives = 169/497 (34%), Gaps = 40/497 (8%) Query: 22 LGIRRRQTGEPPLENGLIPYLGCALQF-GANPLEFLRANQRKHGHVFTCKLMGKYVHFIT 80 + + G+ P P +G LQ + + L +G VFT L K + Sbjct: 1 MAKKTSSKGKLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLH 60 Query: 81 NPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNS 140 + + L + K I + T + + + TL+ + Sbjct: 61 GYEAVKEALVDLGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGK 120 Query: 141 LTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKA 200 S+ + +Q R V KT A + + IF +D + Sbjct: 121 --RSIEDRIQEEARCLVEELRKTNASPCDPTF-ILGCAPCNVICSVIFHNRFDYKDEEFL 177 Query: 201 HILNNLD--------NFKQFDKVFPALVAGLP---IHMFRTAHNAREKLAES-LRHENLQ 248 ++ +L + Q FPAL+ P + + A + + E H+ L Sbjct: 178 KLMESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLL 237 Query: 249 KRESISELISLRMFLNDTLSTFD-DLEKAKTHLVVLW-ASQANTIPATFWSLFQMIRNPE 306 + + I + + + + LE + L+ A T +SL ++++PE Sbjct: 238 DVNNPRDFIDCFLIKMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPE 297 Query: 307 AMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTA 366 EE++R + G + + +P D++I E R L Sbjct: 298 VAARVQEEIERVI----------GRHRSPCMQDRSRMPYTDAVIHEIQRF--IDLLPTNL 345 Query: 367 KEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCN 426 T + +Y I K I + D + +P+P F +LDE+G K Sbjct: 346 PHAVTRDVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKK----- 400 Query: 427 GLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGL 486 Y+MPF +G +C G A E+ FL +L F+L+ + + K + G Sbjct: 401 ----SDYFMPFSAGKRMCVGEGLARMELFLFLTSILQNFKLQSLV-EPKDLDITAVVNGF 455 Query: 487 GILPPLNDIEFKYKFKH 503 +PP + F H Sbjct: 456 VSVPPSYQLCFIPIHHH 472 >3E6I-A nrPDB Length = 476 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 85/499 (17%), Positives = 169/499 (33%), Gaps = 42/499 (8%) Query: 22 LGIRRRQTGEPPLENGLIPYLGCALQFG-ANPLEFLRANQRKHGHVFTCKLMGKYVHFIT 80 + + G+ P +P +G Q N + ++ G VFT + + + + Sbjct: 1 MAKKTSSKGKLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 60 Query: 81 NPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQG----- 135 + + L K + A R I +G T ++I + TL+ Sbjct: 61 GYKAVKEALLDYKDEFSGRGDLPAF-HAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK 119 Query: 136 ----HALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRD 191 + ++E L++ P + +R F+ Sbjct: 120 QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFL--R 177 Query: 192 LTRRDTQKAHILNN-----LDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHEN 246 L + H+L+ +NF F P + ++ E++ E + + Sbjct: 178 LMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLD 237 Query: 247 LQKRESISE--LISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRN 304 +++ L+ + + + T + +A T + L +++ Sbjct: 238 PNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKY 297 Query: 305 PEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIR 364 PE + EE+ R + G + + ++P +D+++ E R +L Sbjct: 298 PEIEEKLHEEIDRVI----------GPSRIPAIKDRQEMPYMDAVVHEIQRF--ITLVPS 345 Query: 365 TAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFY 424 + T Y I K ++ + D + +PDP FK + +L+ENGK K Sbjct: 346 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKY--- 402 Query: 425 CNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRA 484 Y+ PF +G +C G A E+ L +L +F L+ + K L Sbjct: 403 ------SDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVD-PKDIDLSPIHI 455 Query: 485 GLGILPPLNDIEFKYKFKH 503 G G +PP + + H Sbjct: 456 GFGCIPPRYKLCVIPRSHH 474 >5VEU-A nrPDB Length = 480 Score = 241 bits (614), Expect = 7e-64, Method: Composition-based stats. Identities = 88/501 (17%), Positives = 167/501 (33%), Gaps = 56/501 (11%) Query: 21 ILGIRR----RQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYV 76 + G R ++ G P +P LG L + +F +K+G ++ V Sbjct: 3 LYGTRTHGLFKRLGIP--GPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPV 60 Query: 77 HFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGH 136 IT+P VL Y + F +I + + I T Sbjct: 61 LAITDPDVIRTVLVKECYSVFTNRRSLGPVG-FMKSAISLAEDEEWKRIRSLLSPTFTSG 119 Query: 137 ALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRD 196 L + + + ++R K + + T FG ++ + Sbjct: 120 KLKEMFPIIAQYGDVLVRNLRREAEK---GKPVTLKDIFGAYSMDVITGTSFGVNIDSLN 176 Query: 197 T---------QKAHILNNLDNFKQFDKVFPALVAGL--------PIHMFRTAHNAREKLA 239 +K LD +FP L P + ++ Sbjct: 177 NPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMK 236 Query: 240 ESLRHENLQKRESISELISLRMFLNDTLS--TFDDLEKAKTHLVVLWASQANTIPATFWS 297 +S ++ + R +L+ +T S DLE A ++ ++A T ++ Sbjct: 237 KSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFT 296 Query: 298 LFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLS 357 L+++ +P+ + +E+ L N + + + LD ++ E+LRL Sbjct: 297 LYELATHPDVQQKLQKEIDAVLPNKAPP----------TYDAVVQMEYLDMVVNETLRLF 346 Query: 358 SASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENG 417 ++ + +E I K ++ + +H DP+ + +P F+ +R+ + Sbjct: 347 PVAI---RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKD 403 Query: 418 KTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCP 477 Y Y PFG+G C G FA+ +K LI +L F + + Sbjct: 404 SIDP----------YIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPL 453 Query: 478 PLDQSRAGLGILPPLNDIEFK 498 LD G+L P I K Sbjct: 454 KLDTQ----GLLQPEKPIVLK 470 >2PG7-A nrPDB Length = 476 Score = 233 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 79/500 (15%), Positives = 160/500 (32%), Gaps = 43/500 (8%) Query: 22 LGIRRRQTGEPPLENGLIPYLGCALQFGANP-LEFLRANQRKHGHVFTCKLMGKYVHFIT 80 + + G+ P +P++G LQ L ++G VFT L + V + Sbjct: 1 MAKKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC 60 Query: 81 NPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNS 140 + + L + AT F + +G + + I TL+ + Sbjct: 61 GHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGK 120 Query: 141 LTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKA 200 + E +Q + + T + + F R + +FG +D + Sbjct: 121 RG--IEERIQEEAGFLIDALRGTGGANIDPTF-FLSRTVSNVISSIVFGDRFDYKDKEFL 177 Query: 201 HILNNLDNFKQFDK--------VFPALVAGLPIHM---FRTAHNAREKLAESLRHE---- 245 +L + QF +F +++ LP F+ + +A+ + H Sbjct: 178 SLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTL 237 Query: 246 --NLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIR 303 N + S LI ++ + + F T L + + +++ Sbjct: 238 DPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMK 297 Query: 304 NPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI 363 +PE EE+ R + G + +P ++++I E R Sbjct: 298 HPEVEAKVHEEIDRVI----------GKNRQPKFEDRAKMPYMEAVIHEIQRFGDV--IP 345 Query: 364 RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTF 423 + + + + K + + DP + +P F +L+E G+ K Sbjct: 346 MSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKK-- 403 Query: 424 YCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSR 483 ++PF G C G A E+ F ++ F L+ + K + Sbjct: 404 -------SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQ-SPKDIDVSPKH 455 Query: 484 AGLGILPPLNDIEFKYKFKH 503 G +P + F + H Sbjct: 456 VGFATIPRNYTMSFLPRHHH 475 >4R1Z-A nrPDB Length = 439 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 71/349 (20%), Positives = 131/349 (37%), Gaps = 44/349 (12%) Query: 173 SFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFK------QFDKVFPALV--AGLP 224 R + F R D + +L +FP L Sbjct: 102 PELTRAVTNVVCALCFNSSYKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKD 161 Query: 225 IHMFRTAHNAREKLAESLRHENLQ------KRESISELISLRMFLNDTLSTFDDLEKAKT 278 + + R + R+KL + E+ +R+ + L+ + + S+ D+ + Sbjct: 162 LTILRQCISIRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTED 221 Query: 279 HLVV-----LWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPI 333 H+++ A T WS+ ++ NP+ + EE+ + G Sbjct: 222 HVLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKI----------GKER 271 Query: 334 CLSQAELNDLPVLDSIIKESLRLSS--ASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYP 391 ++ +LP L++ I+E LR+ L A +D ++ G Y ++K + + Sbjct: 272 HPQLSDRGNLPYLEATIREVLRIRPVSPLLIPHVALQDSSV----GEYTVQKGTRVVINL 327 Query: 392 QLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAI 451 +H D + + +P F R+L+E G Y+PFG+G +C G A Sbjct: 328 WSLHHDKKEWKNPELFDPGRFLNEEGD-------GLCCPSGSYLPFGAGVRVCLGEALAK 380 Query: 452 HEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYK 500 E+ FL +L F LE+ GQ P L Q + G+ + P + K + Sbjct: 381 MELFLFLAWILQRFTLEMPTGQ-PLPDL-QGKFGVVLQPKKFKVVAKVR 427 >4R20-A nrPDB Length = 486 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 76/470 (16%), Positives = 154/470 (32%), Gaps = 52/470 (11%) Query: 52 PLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAF-- 109 P ++G +F ++ +VL + T+ Sbjct: 41 PHLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQG 100 Query: 110 GHRSIDPMDGNTTENINDTFIKTLQ--GHALNSLTESMMENLQRIMRPPVSSNSKTAAWV 167 G +N + G N L + E + + Sbjct: 101 GKDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAA-----DSLCEELQACRGQ 155 Query: 168 TEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQ------FDKVFPALVA 221 + + R + +F D + ++ D Q +FP L Sbjct: 156 SSDLSVVLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWLRI 215 Query: 222 GLPIHMFR--TAHNAREKL--AESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAK 277 + R + R++L + L H+ +L+ + S D + + Sbjct: 216 FPNKDLKRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGGAD-DITE 274 Query: 278 THLVV-----LWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNP 332 H+++ A T W++ ++ +P+ + E+ + G Sbjct: 275 DHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECV----------GVD 324 Query: 333 ICLSQAELNDLPVLDSIIKESLRLSS--ASLNIRTAKEDFTLHLEDGSYNIRKDDIIALY 390 ++ LP+LD+++ E +R+ L A +D +L G +++ K + + Sbjct: 325 RPPCLSDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSL----GGHSVPKGTRVLVN 380 Query: 391 PQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA 450 +H DP+ + P F +R+L+ +GK KT + ++PFG+G +C G A Sbjct: 381 MWAIHHDPKHWDQPEQFNPERFLEPSGKKKT---------QSSFLPFGAGPRVCVGESLA 431 Query: 451 IHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYK 500 E+ F+ L F +A P L Q R G+ + P + + Sbjct: 432 RIELFLFVSRPLQRFSFS-CPSEASLPDL-QGRFGVVLQPERYTVTVTPR 479 >5UYS-A nrPDB Length = 494 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 81/474 (17%), Positives = 164/474 (34%), Gaps = 57/474 (12%) Query: 33 PLENGLIPYL---GCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVL 89 PL G +P+L G Q+K+G +++ ++ K + + +VL Sbjct: 17 PLV-GSLPFLPRHGHM-------HNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVL 68 Query: 90 CH-GKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKT---LQGHALNSLTESM 145 GK F + + + I D ++ L L + + Sbjct: 69 IKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKII 128 Query: 146 MENLQRIMRPPVSSNSKT---AAWVTEGMYSFCYRVMFEAGYLTIFGR-DLTRRDTQKAH 201 + + + + N ++ + V + + + F Y G +L Sbjct: 129 CQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKN--GDPELNVIQNYNEG 186 Query: 202 ILNNLD-----NFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISEL 256 I++NL + + K+FP + ++ K+ E+ E + + L Sbjct: 187 IIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENY-KEKFRSDSITNML 245 Query: 257 ISLRMFL----------NDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPE 306 +L + D T + A T W+L ++ NP+ Sbjct: 246 DTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQ 305 Query: 307 AMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTA 366 K EE+ Q V P + ++ N L +L++ I+E LRL + + Sbjct: 306 VKKKLYEEID-------QNVGFSRTP---TISDRNRLLLLEATIREVLRLRPVAPMLI-- 353 Query: 367 KEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCN 426 + G + + K + + +H + + + P F +R+L+ G + + Sbjct: 354 PHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVS 413 Query: 427 GLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD 480 Y+PFG+G C G + A E+ + +L F+LE + + P L+ Sbjct: 414 -------YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE-VPDDGQLPSLE 459 >3DL9-A nrPDB Length = 479 Score = 208 bits (530), Expect = 4e-54, Method: Composition-based stats. Identities = 76/472 (16%), Positives = 151/472 (31%), Gaps = 49/472 (10%) Query: 52 PLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHK-VLCHGKYFDWKKFHFATSAKAFG 110 P ++R + +G +F+ L G + + ++ + F + Sbjct: 36 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 95 Query: 111 HRSIDPMDGNTTENINDTFIKTLQ--GHALNSLTESMMENLQRIMRPPVSSNSKTAAWVT 168 ++ G + + + + G+ S ++E + + + Sbjct: 96 GGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEET-KFFNDAIETYKGRPFDFK 154 Query: 169 EGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAH---ILNNLDNFKQFDKVFP----ALVA 221 + + + + L IFG T DT H + + VF + Sbjct: 155 QLITNAVSNIT----NLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIG 210 Query: 222 GLP----IHMFRTAHNAREKLAESLRHENLQKRESISE------LISLRMFLNDTLSTFD 271 LP +FR A + L+ + ++ ++ + + L + ND STF Sbjct: 211 ILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFS 270 Query: 272 DLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGN 331 + ++ A T W++ M P +E+ + G+ Sbjct: 271 KENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP------ 324 Query: 332 PICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYP 391 S + +P ++++ E LR ++ + Y+I K + Sbjct: 325 ----SWDDKCKMPYTEAVLHEVLRF--CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNL 378 Query: 392 QLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAI 451 +H D + + DP F +R+LD +G K +PF G C G A Sbjct: 379 YSVHFDEKYWRDPEVFHPERFLDSSGYFAK---------KEALVPFSLGRRHCLGEHLAR 429 Query: 452 HEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKH 503 E+ F +L F L P L R G+ + P I + + H Sbjct: 430 MEMFLFFTALLQRFHLHFPHEL--VPDLKP-RLGMTLQPQPYLICAERRHHH 478 >2HI4-A nrPDB Length = 495 Score = 208 bits (529), Expect = 5e-54, Method: Composition-based stats. Identities = 82/465 (17%), Positives = 150/465 (32%), Gaps = 44/465 (9%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITN-PLSYHKVLC 90 PP G P LG L G NP L +++G V ++ V ++ ++ Sbjct: 18 PPEPWGW-PLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVR 76 Query: 91 HGKYFDWKKFHFATSAKAFGH-RSIDPMDGNTTENINDTFIKTLQGHALNSLTES----- 144 G F + + ++ G + G L ++ S S Sbjct: 77 QGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCY 136 Query: 145 MMENLQRIMRPPVS-SNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHIL 203 + E++ + + +S A Y+ + FG+ + ++ Sbjct: 137 LEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLV 196 Query: 204 NNLDNFK------QFDKVFPALVAGLPIHMFRTAHNAREK----LAESLRH-----ENLQ 248 N F FP L LP + ++ L ++++ + Sbjct: 197 KNTHEFVETASSGNPLDFFPILR-YLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNS 255 Query: 249 KRESISELIS-LRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEA 307 R+ L + + + + + A A WSL ++ PE Sbjct: 256 VRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEI 315 Query: 308 MKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAK 367 + +E+ + G ++ LP L++ I E+ R S S T Sbjct: 316 QRKIQKELDTVI----------GRERRPRLSDRPQLPYLEAFILETFRHS--SFLPFTIP 363 Query: 368 EDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNG 427 T + I K + + ++ DPE++ DP F+ +R+L +G Sbjct: 364 HSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKP---- 419 Query: 428 LKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEG 472 L M FG G C G + A EI FL ++L E + G Sbjct: 420 --LSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 462 >6DWN-A nrPDB Length = 491 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 79/467 (16%), Positives = 146/467 (31%), Gaps = 47/467 (10%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITN-PLSYHKVLC 90 PP G P +G L G NP L +++G V ++ V ++ ++ Sbjct: 13 PPGPWGW-PLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR 71 Query: 91 HGKYFDWKKFHFATSAKAFGHRS-IDPMDGNTTENINDTFIKTLQGHALNSLTES----- 144 G F + + + + G P G L+ ++ S S Sbjct: 72 QGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCY 131 Query: 145 MMENLQRIMRPPVSS-NSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHI- 202 + E++ + +S+ A Y + + FGR + + Sbjct: 132 LEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLV 191 Query: 203 -----LNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRH---------ENLQ 248 + F ++ LP + EK ++ E Sbjct: 192 NLNNNFGEVVGSGNPAD-FIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGH 250 Query: 249 KRESISELIS---LRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNP 305 R+ LI + + D + L + A A WSL ++ NP Sbjct: 251 IRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNP 310 Query: 306 EAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRT 365 + EE+ + G ++ + LP +++ I E+ R S S T Sbjct: 311 RVQRKIQEELDTVI----------GRSRRPRLSDRSHLPYMEAFILETFRHS--SFVPFT 358 Query: 366 AKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYC 425 T + I K + + ++ D +++ +P F +R+L +G Sbjct: 359 IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKV--- 415 Query: 426 NGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEG 472 L + FG G C G A E+ FL ++L E + G Sbjct: 416 ----LSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLG 458 >6C94-A nrPDB Length = 497 Score = 205 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 72/424 (16%), Positives = 135/424 (31%), Gaps = 52/424 (12%) Query: 72 MGKYVHFIT--NPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTF 129 +G+++ F+ P V G + F G +D G Sbjct: 63 VGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGKGLLVLD---GPKWFQHRKLL 119 Query: 130 IKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFG 189 L ++ + ++ K + ++S + + FG Sbjct: 120 TPGFHYDVLKPYVAIFADSTRIMLEKW---EKKACEGKSFDIFSDVGHMALDTLMKCTFG 176 Query: 190 RD---LTRRDTQKAHILNNL--------DNFKQFDKVFPALVAGLPIHMFRTAHNA---- 234 + L RD+ ++ L D+F+ + F + R A Sbjct: 177 KGDSGLNHRDSSYYVAVSELTLLMQQRIDSFQYHND-FIYWLTPHGRRFLRACRAAHDHT 235 Query: 235 -------REKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQ 287 + L + E +Q R + L L ++ D + ++ Sbjct: 236 DRVIRQRKAALQDEKEREKIQNRRHLDFLDILLDVRGESGVQLSDTDLRAEVDTFMFEGH 295 Query: 288 ANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLD 347 T W L+ M PE + EEV+ L G+ +L + L Sbjct: 296 DTTTSGISWFLYCMALYPEHQQRCREEVREIL----------GDQDSFQWEDLAKMTYLT 345 Query: 348 SIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTF 407 +KE RL + ++ S + +I+L+ +H + +++PDP F Sbjct: 346 MCMKECFRLYPPVPQVYRQLSKPVSFVDGRS--LPAGSLISLHIYALHRNSDVWPDPEVF 403 Query: 408 KYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFEL 467 R+ EN + Y ++PF +G C G+ FA++E+K L L FE Sbjct: 404 DPLRFSPENSSGRHP---------YAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEF 454 Query: 468 ELIE 471 + Sbjct: 455 SVDP 458 >3MDV-A nrPDB Length = 456 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 81/453 (17%), Positives = 141/453 (31%), Gaps = 48/453 (10%) Query: 54 EFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVL----CHGKYFDWKKFHFATSAKAF 109 + +K+G V + K +T+P S K L + ++ + F Sbjct: 14 DVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLF 73 Query: 110 GHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTE 169 G + + +L SL E+ E ++++ +K Sbjct: 74 GQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEI---LEAKADGQTPV 130 Query: 170 GMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFR 229 M + FG + + + + + + +A + Sbjct: 131 SMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRK 190 Query: 230 TAHNAREKL---------AESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHL 280 RE + R E L++ E + I L L DD + Sbjct: 191 QLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADI-LTQILKAEEGAQDDEGLLDNFV 249 Query: 281 VVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAEL 340 A + +++ ++ R PE + EV + G+ L +L Sbjct: 250 TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVI----------GSKRYLDFEDL 299 Query: 341 NDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEI 400 L L ++KESLRL + E+ TL + + + +M Sbjct: 300 GRLQYLSQVLKESLRLYPPAWGTFRLLEEETL---IDGVRVPGNTPLLFSTYVMGRMDTY 356 Query: 401 YPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLIL 460 + DPLTF DR+ K ++ Y PF G C G+ FA E+K + Sbjct: 357 FEDPLTFNPDRF-----------GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAK 405 Query: 461 MLSYFELELIEG-------QAKCPPLDQSRAGL 486 +L E L+ G QA PLD L Sbjct: 406 LLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTL 438 >3TBG-A nrPDB Length = 479 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 75/481 (15%), Positives = 143/481 (29%), Gaps = 52/481 (10%) Query: 46 LQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITN-PLSYHKVLCHGKYFDWKKFHFAT 104 + F P F +R+ G VF+ +L V + ++ HG+ + T Sbjct: 27 VDFQNTPYCF-DQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPIT 85 Query: 105 SAKAFGHRSIDPMD---GNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNS 161 FG RS G + TL+ L + + +N Sbjct: 86 QILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANH 145 Query: 162 KTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILN---------------NL 206 + G+ + + GR D + +L+ L Sbjct: 146 SGRPFRPNGLLD---KAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVL 202 Query: 207 DNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLR---HENLQKRESISELISLRMFL 263 + + PAL + E L E + + + L + Sbjct: 203 NAVPVLLHI-PALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAK 261 Query: 264 NDTLSTFDDLEKAKTHLVVLW-ASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENA 322 + S+F+D E + + L+ A T W L MI +P+ + +E+ + Sbjct: 262 GNPESSFND-ENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV 320 Query: 323 GQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIR 382 + + +P ++I E R + + +E + I Sbjct: 321 RRP----------EMGDQAHMPYTTAVIHEVQRF--GDIVPLGVTHMTSRDIEVQGFRIP 368 Query: 383 KDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGAT 442 K + + D ++ P F + +LD G ++PF +G Sbjct: 369 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKP---------EAFLPFSAGRR 419 Query: 443 ICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFK 502 C G A E+ F +L +F + GQ + P + P ++ + Sbjct: 420 ACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR--PSHHGVFAFLVSPSPYELCAVPRHH 477 Query: 503 H 503 H Sbjct: 478 H 478 >5VBU-A nrPDB Length = 476 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 83/488 (17%), Positives = 147/488 (30%), Gaps = 53/488 (10%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCH 91 PPL G + L L +L +K G ++ L G + N + Sbjct: 12 PPLAPGFLHLLQPDLPI------YLLGLTQKFGPIYRLHL-GLQDVVVLNSKRTIEEAMV 64 Query: 92 GKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQR 151 K+ D+ + K D G+ + K L AL ME + Sbjct: 65 KKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLL--WKAHKKLTRSALLLGIRDSMEPVVE 122 Query: 152 IMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAH-------ILN 204 + + + + FG + + A+ + Sbjct: 123 QLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKT 182 Query: 205 NLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESI--SELISLRMF 262 Q V P L P R A EK + + Q +ES+ + + + Sbjct: 183 WSHWSIQIVDVIPFLR-FFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDY 241 Query: 263 LNDTLSTFDDLEKAKTHLV---------VLWASQANTIPATFWSLFQMIRNPEAMKAATE 313 + ++ E + L +L T W++ ++ +PE + E Sbjct: 242 MLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQE 301 Query: 314 EVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLH 373 E+ L + + LP+L++ I E LRL T Sbjct: 302 ELDHELGPGASSSR-------VPYKDRARLPLLNATIAEVLRLRPV--VPLALPHRTTRP 352 Query: 374 LEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYY 433 Y+I + +I Q HLD ++ P F DR+L+ ++ Sbjct: 353 SSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRA------------ 400 Query: 434 YMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQS-RAGLGILPPL 492 + FG GA +C G A E+ L +L F L+ P L + + Sbjct: 401 -LAFGCGARVCLGEPLARLELFVVLTRLLQAFT--LLPSGDALPSLQPLPHCSVILKMQP 457 Query: 493 NDIEFKYK 500 + + + Sbjct: 458 FQVRLQPR 465 >3K9V-A nrPDB Length = 482 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 87/499 (17%), Positives = 173/499 (34%), Gaps = 58/499 (11%) Query: 26 RRQTGEPPLENGLIPYLGCALQFG-----ANPLEFLRANQRKHGHVFTCKLMGKYVHFIT 80 R + P P LG L+ + L +K+G +F KL + Sbjct: 20 TRNVTDLPGPTNW-PLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLG 78 Query: 81 NPLSYHKVLCHGKYFDWKKFHFATSAKAFGHR----SIDPMDGNTTENINDTFIKTLQG- 135 +P S + L + ++ HR + ++G + + F K L Sbjct: 79 SP-SLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKP 137 Query: 136 HALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTI----FG-- 189 + L + + E L + +YS + FE+ L + FG Sbjct: 138 VEIMKLDKKINEVLADFLERM--DELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLL 195 Query: 190 -RDLTRRDTQKAHILNNLDNFKQFDKVFP-ALVAGLPIHMFRTAHNAREKLAESLRH--- 244 ++ + + + V P L L +++ A + + +S++ Sbjct: 196 QKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCID 255 Query: 245 ENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRN 304 LQ+ L E + A+ T + W L+ + RN Sbjct: 256 NRLQRYSQQPGADFLCDIYQQ--DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 313 Query: 305 PEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSS-ASLNI 363 P+A + +EV+ L + +L ++P L + +KES+RL+ Sbjct: 314 PQAQRRLLQEVQSVLP----------DNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT 363 Query: 364 RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTF 423 RT + L G Y + K ++ L Q++ + + D F+ +R+L + K Sbjct: 364 RTLDKPTVL----GEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINP-- 417 Query: 424 YCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSR 483 + ++PFG G +C GR A ++ L ++ +++ + + Sbjct: 418 --------FAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPV------EM 463 Query: 484 AGLGILPPLNDIEFKYKFK 502 LGIL P ++ ++ + Sbjct: 464 LHLGILVPSRELPIAFRPR 482 >3QZ1-A nrPDB Length = 496 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 86/486 (17%), Positives = 151/486 (31%), Gaps = 50/486 (10%) Query: 32 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCH 91 PPL G + L L L + +K G V+ +L + V + + + + + Sbjct: 31 PPLVPGFLHLLQPNLPI------HLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMI- 83 Query: 92 GKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQR 151 K+ D+ S K R D G+ + K L AL T S ME Sbjct: 84 RKWVDFAGRPQIPSYKLVSQRCQDISLGDYSLL--WKAHKKLTRSALLLGTRSSMEPWVD 141 Query: 152 IMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNL----- 206 + + A + + FG + +L Sbjct: 142 QLTQEFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLMKTWD 201 Query: 207 DNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESI--SELISLRMFLN 264 Q + P L P A E + + + +ES+ + + ++ Sbjct: 202 HWSIQILDMVPFLR-FFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYML 260 Query: 265 DTLSTFDDLE--------KAKTHLVVLW-ASQANTIPATFWSLFQMIRNPEAMKAATEEV 315 + E +V L+ T W++ ++ +PE + EE+ Sbjct: 261 QGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEEL 320 Query: 316 KRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLE 375 R L ++ + LP+L++ I E LRL T Sbjct: 321 DRELGPGASCSR-------VTYKDRARLPLLNATIAEVLRLRPV--VPLALPHRTTRPSS 371 Query: 376 DGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYM 435 Y+I + ++ Q HLD ++ P F+ DR+L+ + Sbjct: 372 IFGYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANP-------------SAL 418 Query: 436 PFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQS-RAGLGILPPLND 494 FG GA +C G A E+ L +L F L L P L G+ + Sbjct: 419 AFGCGARVCLGESLARLELFVVLARLLQAFTL-LPPPVGALPSLQPDPYCGVNLKVQPFQ 477 Query: 495 IEFKYK 500 + + + Sbjct: 478 VRLQPR 483 >3MZS-A nrPDB Length = 486 Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats. Identities = 88/502 (17%), Positives = 166/502 (33%), Gaps = 58/502 (11%) Query: 31 EPPLENGLIPYLGCALQFGANPLEF-LRANQRKHGHVFTCKLMGKYVHFITNPLS-YHKV 88 P +NG + + G+ + F N +K+G ++ KL +I +P H Sbjct: 14 PSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLF 73 Query: 89 LCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFI---KTLQGHALNSLTESM 145 G Y + + + + I + + D + + + A+ + + Sbjct: 74 KFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLL 133 Query: 146 MENLQRIM-----RPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDL---TRRDT 197 Q + R + K + E ++ F + + +FG L Sbjct: 134 NPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNV----MFGERLGMLEETVN 189 Query: 198 QKAH-----ILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNA------REKLAESLRHEN 246 +A + V P L +R A + + + +++ Sbjct: 190 PEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQD 249 Query: 247 LQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATF-WSLFQMIRNP 305 L+++ + L + LE K ++ + A NT T W L++M R+ Sbjct: 250 LRRKTEFRNYPGILYCLLKSEKML--LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSL 307 Query: 306 EAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRT 365 + EEV A +S L +P+L + IKE+LRL S+ ++ Sbjct: 308 NVQEMLREEVLNARRQAEGDIS----------KMLQMVPLLKASIKETLRLHPISVTLQR 357 Query: 366 AKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYC 425 E L Y I ++ + M DP + P F R+L ++ Sbjct: 358 YPES---DLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIH---- 410 Query: 426 NGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD----Q 481 + + FG G C GR A E+ FLI +L F++E+ + Sbjct: 411 ------FRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTP 464 Query: 482 SRAGLGILPPLNDIEFKYKFKH 503 + + P N + H Sbjct: 465 DKPIFLVFRPFNQDPPQAHHHH 486 >6IQ5-A nrPDB Length = 463 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 70/472 (14%), Positives = 148/472 (31%), Gaps = 49/472 (10%) Query: 56 LRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSID 115 R++G VF +L + + + H+ L + FA+ G RS+ Sbjct: 7 FARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGRSMA 66 Query: 116 PMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFC 175 + + ++ + S ++ + +G + Sbjct: 67 FGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDP 126 Query: 176 YRVMF----EAGYLTIFGRDLTRRDTQKAHILNNLDNF------------KQFDKVFPAL 219 + FG + D + +L++ + F + + FP Sbjct: 127 RPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNP 186 Query: 220 VAGLPIHMFRTAHNAREKLAESLRH--ENLQKRESISELISLRMFLNDTLSTFD------ 271 V + + N + + E+L+ + +++ + + + D Sbjct: 187 VRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGA 246 Query: 272 --DLEKAKTHLVVLW-ASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSL 328 DLE + ++ ASQ A W L R P+ E+ + + Sbjct: 247 RLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVV--------- 297 Query: 329 EGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIA 388 G + +LP + + + E++R S S T T + Y+I KD ++ Sbjct: 298 -GRDRLPCMGDQPNLPYVLAFLYEAMRFS--SFVPVTIPHATTANTSVLGYHIPKDTVVF 354 Query: 389 LYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRL 448 + ++ DP +P+P F R+LD++G M F G C G Sbjct: 355 VNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRV-------MIFSVGKRRCIGEE 407 Query: 449 FAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYK 500 + ++ F+ ++ + + GL I P + + Sbjct: 408 LSKMQLFLFISILAHQCDFRANPNEPAKMNFS---YGLTIKPKSFKVNVTLR 456 >4KPA-A nrPDB Length = 494 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 78/432 (18%), Positives = 152/432 (35%), Gaps = 45/432 (10%) Query: 51 NPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFG 110 P++ L + G +F + G+ ++++ + C FD + F Sbjct: 48 KPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKE-ACDESRFDKNLSQALKFVRDFA 106 Query: 111 HRSIDPMDGNTT--ENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVT 168 + + + ++ + + A+ M++ ++++ N+ V Sbjct: 107 GDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVP 166 Query: 169 EGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLP---- 224 E M R+ + L F + H + D+ L P Sbjct: 167 EDMT----RLTLDTIGLCGFNYRFNSFYRDQPHPFIT-SMVRALDEAMNKLQRANPDDPA 221 Query: 225 ----IHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLND--TLSTFDDLEKAKT 278 F+ L + + + E +L++ + D T DD Sbjct: 222 YDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQ 281 Query: 279 HLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQA 338 + L A T ++L+ +++NP ++ A EE R L + S Sbjct: 282 IITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVD-----------PVPSYK 330 Query: 339 ELNDLPVLDSIIKESLRLSS-ASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLD 397 ++ L + ++ E+LRL A AKED L G Y + K D + + +H D Sbjct: 331 QVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVL---GGEYPLEKGDELMVLIPQLHRD 387 Query: 398 PEIY-PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQ 456 I+ D F+ +R+ + + + + PFG+G C G+ FA+HE Sbjct: 388 KTIWGDDVEEFRPERFENPSAIPQH-----------AFKPFGNGQRACIGQQFALHEATL 436 Query: 457 FLILMLSYFELE 468 L +ML +F+ E Sbjct: 437 VLGMMLKHFDFE 448 >3N9Z-A nrPDB Length = 487 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 73/436 (16%), Positives = 129/436 (29%), Gaps = 52/436 (11%) Query: 58 ANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPM 117 N +K+G ++ KL ++ +P + K F H+ Sbjct: 40 QNFQKYGPIYREKLGNVESVYVIDPEDVALLF---KSEGPNPERFLIPPWVAYHQYYQRP 96 Query: 118 DGNTTENIND-------TFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEG 170 G + + + A + + + + K + G Sbjct: 97 IGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSG 156 Query: 171 MY-SFCYRVMFEAGYLTIFGRD---LTRRDTQKAH-----ILNNLDNFKQ----FDKVFP 217 +R FE+ IFG L +A I +F Sbjct: 157 DISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFR 216 Query: 218 ALVAGLPIHMFRTAHNAREK----LAESLRHENLQKRESISELISLRMFLNDTLSTFDDL 273 K + L L D+ +F+D+ Sbjct: 217 LFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDI 276 Query: 274 EKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPI 333 + T ++ T W L++M RN + EV A ++ Sbjct: 277 KANVTEMLA--GGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATM---- 330 Query: 334 CLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQL 393 L +P+L + IKE+LRL S+ ++ + L Y I ++ + Sbjct: 331 ------LQLVPLLKASIKETLRLHPISVTLQRYLVN---DLVLRDYMIPAKTLVQVAIYA 381 Query: 394 MHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHE 453 + +P + DP F R+L ++ + + FG G C GR A E Sbjct: 382 LGREPTFFFDPENFDPTRWLSKDKNITY----------FRNLGFGWGVRQCLGRRIAELE 431 Query: 454 IKQFLILMLSYFELEL 469 + FLI ML F +E+ Sbjct: 432 MTIFLINMLENFRVEI 447 >3S79-A nrPDB Length = 503 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 78/424 (18%), Positives = 149/424 (35%), Gaps = 47/424 (11%) Query: 61 RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFD-WKKFHFATSAKAFGHRSIDPMDG 119 R +G + G+ I+ S ++ H Y + I + Sbjct: 79 RVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNP 138 Query: 120 NTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVM 179 + F+K L G L + E+L+ + T + + RVM Sbjct: 139 ELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLD---RLEEVTNESGYVDVLTLLRRVM 195 Query: 180 FEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHM-FRTAHNAREKL 238 + T+F L + A ++ F + + I ++ + + L Sbjct: 196 LDT-SNTLF---LRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDL 251 Query: 239 AESLRHENLQKRESISELISLRMFLN--------DTLSTFDDLEKAKTHLVVLWASQANT 290 +++ +KR IS L ++ + + L +L A+ Sbjct: 252 KDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTM 311 Query: 291 IPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSII 350 + F+ LF + ++P +A +E++ + K+ ++ L V+++ I Sbjct: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI-----------DDIQKLKVMENFI 360 Query: 351 KESLRLSSA-SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKY 409 ES+R L +R A ED + Y ++K I L MH E +P P F Sbjct: 361 YESMRYQPVVDLVMRKALEDDVID----GYPVKKGTNIILNIGRMHR-LEFFPKPNEFTL 415 Query: 410 DRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELEL 469 + + K Y Y+ PFG G C G+ A+ +K L+ +L F ++ Sbjct: 416 ENF------AKNVPYR-------YFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKT 462 Query: 470 IEGQ 473 ++GQ Sbjct: 463 LQGQ 466 >4ZGX-A nrPDB Length = 489 Score = 153 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 73/420 (17%), Positives = 141/420 (33%), Gaps = 60/420 (14%) Query: 56 LRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFH--FATSAKAFGHRS 113 + ++ G +F L G + + P K+ + + + GH+ Sbjct: 45 MHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKC 104 Query: 114 IDPMDGNTTENINDTFIKT--LQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWV--TE 169 + N + L A+ M++ + R + A T Sbjct: 105 GVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLP-MVDAVARDFSQALKKKVLQNARGSLTL 163 Query: 170 GMYSFCYRVMFEAGYLTIFGRDL-------TRRDTQKAHIL-----NNLDNFKQFDKVFP 217 + + EA L +FG L + H L + + + Sbjct: 164 DVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSR 223 Query: 218 ALVAGLPIHMF-------RTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTF 270 + + F + N +K+ + L Q I + L+ L+ Sbjct: 224 WISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS------ 277 Query: 271 DDLEKAKTHLVVLWAS-QANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLE 329 LE K + + L A T +LF++ RNP+ + +E + S+ Sbjct: 278 --LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE------SLAAAASIS 329 Query: 330 GNPICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIA 388 +P Q +LP+L + +KE+LRL L + R D L +Y+I ++ Sbjct: 330 EHP----QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQ----NYHIPAGTLVQ 381 Query: 389 LYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRL 448 ++ + + ++P P + R+LD G + ++++PFG G C GR Sbjct: 382 VFLYSLGRNAALFPRPERYNPQRWLDIRGSGRN----------FHHVPFGFGMRQCLGRR 431 >6M7X-A nrPDB Length = 484 Score = 152 bits (384), Expect = 3e-37, Method: Composition-based stats. Identities = 78/414 (18%), Positives = 142/414 (34%), Gaps = 58/414 (14%) Query: 61 RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKK--FHFATSAKAFGHR--SIDP 116 ++ G +F L G + + P K+ + + + GH+ Sbjct: 50 QELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLL 109 Query: 117 MDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWV--TEGMYSF 174 N + L +A+ M++ + R + A T + Sbjct: 110 NGPEWRFNRLRLNPEVLSPNAVQRFLP-MVDAVARDFSQALKKKVLQNARGSLTLDVQPS 168 Query: 175 CYRVMFEAGYLTIFGRDL-------TRRDTQKAHIL-----NNLDNFKQFDKVFPALVAG 222 + EA L +FG L + H L + + + Sbjct: 169 IFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPK 228 Query: 223 LPIHMF-------RTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEK 275 + F + N +K+ + L Q+ SI + LN LS D ++ Sbjct: 229 VWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIV----AELLLNAELSP-DAIKA 283 Query: 276 AKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICL 335 L S T+ +LF++ RNP +A +E + S+ +P Sbjct: 284 NSMELTA--GSVDTTVFPLLMTLFELARNPNVQQALRQE------SLAAAASISEHP--- 332 Query: 336 SQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLM 394 Q +LP+L + +KE+LRL L + R A D L +Y+I ++ ++ + Sbjct: 333 -QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQ----NYHIPAGTLVRVFLYSL 387 Query: 395 HLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRL 448 +P ++P P + R+LD G + +Y++PFG G C GR Sbjct: 388 GRNPALFPRPERYNPQRWLDIRGSGRN----------FYHVPFGFGMRQCLGRR 431 >3NC3-A nrPDB Length = 441 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 74/422 (17%), Positives = 134/422 (31%), Gaps = 62/422 (14%) Query: 47 QFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSA 106 QF NP + + + + + +FI+ +L H F K + Sbjct: 50 QFQNNPYAYFSQLREEDPVHYEESIDS---YFISRYHDVRYILQHPDIFTTKSLVER-AE 105 Query: 107 KAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAW 166 + M G +++ G AL+ L+ + +N + ++ P + Sbjct: 106 PVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALDHLSPLIKQNAENLLAPYLERGKSDLVN 165 Query: 167 VTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIH 226 ++ C + + G L +RD +K I F Sbjct: 166 DFGKTFAVCVTM-------DMLG--LDKRDHEK--ISEWHSGVADFITSISQSP-----E 209 Query: 227 MFRTAHNAREKLAESLRHENLQKRESI-SELISLRMFLNDTLSTFDDLEKAKTHLVVLWA 285 + E+L++ L ++R + S+LIS+ D + L VL A Sbjct: 210 ARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMALSDKDILALILNVLLA 269 Query: 286 SQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPV 345 + ++ ++ NPE M A+ + +P Sbjct: 270 ATEPADKTLALMIYHLLNNPEQMNDV-------------------------LADRSLVP- 303 Query: 346 LDSIIKESLRLSSAS-LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDP 404 I E+LR L R +D + G I+KD I+ + DPE + P Sbjct: 304 --RAIAETLRYKPPVQLIPRQLSQDTVV----GGMEIKKDTIVFCMIGAANRDPEAFEQP 357 Query: 405 LTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSY 464 F R + + ++ FGSG C G FA +EI+ ++L Sbjct: 358 DVFNIHR--------EDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDK 409 Query: 465 FE 466 Sbjct: 410 MR 411 >3DBM-A nrPDB Length = 473 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 34/187 (18%), Positives = 77/187 (41%), Gaps = 18/187 (9%) Query: 293 ATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKE 352 W N EE++ +++ G ++ + +P+ S++ E Sbjct: 288 TLKWIGLA-GENLHTQ--LAEEIRGAIKSYGDG--------NVTLEAIEQMPLTKSVVYE 336 Query: 353 SLRLSSA-SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDR 411 SLR+ AK +FT+ D ++ ++K +++ Y DP+++ P + DR Sbjct: 337 SLRIEPPVPPQYGKAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDR 396 Query: 412 YL-DENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFE-LEL 469 ++ D K ++ NG + + + C G+ F + + F+I + ++ E+ Sbjct: 397 FVGDGEALLKYVWWSNGPETESPTV----ENKQCAGKDFVVLITRLFVIELFRRYDSFEI 452 Query: 470 IEGQAKC 476 G++ Sbjct: 453 ELGESPL 459 >2VZM-A nrPDB Length = 436 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 74/455 (16%), Positives = 134/455 (29%), Gaps = 86/455 (18%) Query: 47 QFGANPLEFLRANQRKHGHVFTCKL-MGKYVHFITNPLSYHKVLCHGKYF-DWKKFHFAT 104 F A+P + + G + G V + VL ++ DW+ Sbjct: 43 DFAADPYPTYARLRAE-GPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPL 101 Query: 105 SAK--AFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSK 162 + A H ++ D + + + L + E + ++ +++ Sbjct: 102 TEAEAALNHNMLE-SDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDG 160 Query: 163 TAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAG 222 A + + V+ E + G + D + + VFP A Sbjct: 161 RADLMESLAWPLPITVISE-----LLG--VPEPDRAAFRVWTD-------AFVFPDDPA- 205 Query: 223 LPIHMFRTAHNAREKLAESLRHENLQKR--ESISELISLRMFLNDTLSTFDDLEKAKTHL 280 A A +++ L KR + L +L ++ S E Sbjct: 206 -------QAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAH 258 Query: 281 VVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAEL 340 ++L A T+ ++ ++ +P+ + A Sbjct: 259 ILLVAGHETTVNLIANGMYALLSHPDQLAALRA--------------------------- 291 Query: 341 NDLPVLDSIIKESLRLSSA--SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDP 398 D+ +LD ++E LR S R E L I D + + H P Sbjct: 292 -DMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLD----GTVIPAGDTVLVVLADAHRTP 346 Query: 399 EIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFL 458 E +PDP F R ++ FG G C G A E + + Sbjct: 347 ERFPDPHRFDIRR------------------DTAGHLAFGHGIHFCIGAPLARLEARIAV 388 Query: 459 ILMLSY---FELELIEGQAKCPPLDQSRAGLGILP 490 +L L++ G+ P R GL LP Sbjct: 389 RALLERCPDLALDVSPGELVWYPNPMIR-GLKALP 422 >2RCM-A nrPDB Length = 495 Score = 104 bits (258), Expect = 1e-22, Method: Composition-based stats. Identities = 63/463 (13%), Positives = 146/463 (31%), Gaps = 61/463 (13%) Query: 36 NGLIPYLGCALQ-----FGANPLEFLRANQRKH-GHVFTCKLMG-------KYVHFITNP 82 N +P +G + EF ++ RK+ V+ + V + + Sbjct: 33 NYGLPIVGPIKDRWDYFYDQGAEEFFKSRIRKYNSTVYRVNMPPGAFIAENPQVVALLDG 92 Query: 83 LSYHKVL-----CHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHA 137 S+ + + S E + + L+ Sbjct: 93 KSFPVLFDVDKVEKKDLLTGTYMPSTELTGGYRILSYLDPSEPKHEKLKNLLFFLLKSSR 152 Query: 138 ------LNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRD 191 + + ++L++ + ++ ++ T F +G + Sbjct: 153 NRIFPEFQATYSELFDSLEKELSLKGKADFGGSSDGT----------AFNFLARAFYGTN 202 Query: 192 LTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRE 251 DT+ L + P L GLP + + L +L + Q+ Sbjct: 203 PA--DTKLKADAPGLITKWVLFNLHPLLSIGLPRVIEEPLIHTFS-LPPALVKSDYQRLY 259 Query: 252 SISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRN-----PE 306 + + + E L+A+ NT M++ + Sbjct: 260 EFFLESAGEILVEADKLGISREEATHNL---LFATCFNTWGGMKILFPNMVKRIGRAGHQ 316 Query: 307 AMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS-LNIRT 365 EE++ +++ G + L+ + + + S++ E LR Sbjct: 317 VHNRLAEEIRSVIKSNGGE---------LTMGAIEKMELTKSVVYECLRFEPPVTAQYGR 367 Query: 366 AKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKT--KTTF 423 AK+D + D ++ ++ +++ Y L DP+I+ F +R++ E G+ + Sbjct: 368 AKKDLVIESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLLRHVL 427 Query: 424 YCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFE 466 + NG + + + G C G+ F + + F+I + ++ Sbjct: 428 WSNGPETETPTV----GNKQCAGKDFVVLVARLFVIEIFRRYD 466 >1WIY-A nrPDB Length = 389 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 73/454 (16%), Positives = 126/454 (27%), Gaps = 84/454 (18%) Query: 47 QFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSA 106 +PL L R H +F L + I +P L + F + + Sbjct: 15 DLQQDPLAVLLEWGRAHPRLF-LPLPRFPLALIFDPEGVEGALL-AEGTTKATFQYRALS 72 Query: 107 KAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAW 166 + G R + G + + ++ E+M E Sbjct: 73 RLTG-RGLLTDWGKSWKEARKALKDPFLPKSVRGYREAMEEEAWAFFGEWR----GEERD 127 Query: 167 VTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIH 226 + M + R++ A +FG+ L+ + A K D++ + L + Sbjct: 128 LDHEMLALSLRLLGRA----LFGKPLSPSLAEHA--------LKALDRIMAQTRSPLALL 175 Query: 227 MFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWAS 286 R+ R + ++ LS + +L A Sbjct: 176 DLAAEARFRKDRGALYREAEA-------------LIVHPPLSHLPRERALSEAVTLLVAG 222 Query: 287 QANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL 346 A WS + P+ K E + L Sbjct: 223 HETVASALTWSFLLLSHRPDWQKRVAESEEAALAAF------------------------ 258 Query: 347 DSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLT 406 +E+LRL + + E L ED + + + L P + +P+ Sbjct: 259 ----QEALRLYPPAWILTRRLERPLLLGEDR---LPQGTTLVLSPYVTQRL--YFPEGEA 309 Query: 407 FKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFE 466 F+ +R+L E G Y PFG G +C GR FA+ E L F Sbjct: 310 FQPERFLAERGTP-----------SGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFR 358 Query: 467 LELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYK 500 L P L P + + + Sbjct: 359 L--------DPLPFPRVLAQVTLRPEGGLPARPR 384 >3EJB-B nrPDB Length = 404 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 53/424 (12%), Positives = 122/424 (28%), Gaps = 73/424 (17%) Query: 47 QFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSA 106 +F NP F + H ++ + ++T +L ++ +++ Sbjct: 10 EFLKNPYSFYDTLRAVH-PIYKGSFLKYPGWYVTGYEETAAILKDARFKVRTPLPESSTK 68 Query: 107 KA-FGHR---SIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSK 162 H + + + S ++E + ++ K Sbjct: 69 YQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTPRTTESYQPYIIETVHHLLDQV--QGKK 126 Query: 163 TAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAG 222 +++ + V+ + + + + A L +F + K Sbjct: 127 KMEVISDFAFPLASFVIANIIGVP---EEDREQLKEWAASLIQTIDFTRSRKAL------ 177 Query: 223 LPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVV 282 A A E ++ ++ + + + + E A T +++ Sbjct: 178 --TEGNIMAVQAMAYFKELIQK----RKRHPQQDMISMLLKGREKDKLTEEEAASTCILL 231 Query: 283 LWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELND 342 A T+ S+ ++++PE + E Sbjct: 232 AIAGHETTVNLISNSVLCLLQHPEQLLKLRENPD-------------------------- 265 Query: 343 LPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIY 401 ++ + ++E LR S + R A ED + IR+ + + L + DP I+ Sbjct: 266 --LIGTAVEECLRYESPTQMTARVASEDIDIC----GVTIRQGEQVYLLLGAANRDPSIF 319 Query: 402 PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILM 461 +P F R ++ FG G +C G A E + + + Sbjct: 320 TNPDVFDITR------------------SPNPHLSFGHGHHVCLGSSLARLEAQIAINTL 361 Query: 462 LSYF 465 L Sbjct: 362 LQRM 365 >6FYJ-A nrPDB Length = 421 Score = 99.2 bits (245), Expect = 4e-21, Method: Composition-based stats. Identities = 58/436 (13%), Positives = 121/436 (27%), Gaps = 62/436 (14%) Query: 44 CALQFGANPLEFLRANQRKH-GHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHF 102 + ++ + +F +L+GK + + K+ Sbjct: 17 STWRLMEEGYMYILNRRHSFNSDIFETRLLGKKAICMGGKEAAEIFYDTEKFKRKDAAPN 76 Query: 103 ATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSK 162 FG + +DG T ++ + F+ + L LT+ + + + + Sbjct: 77 RVVQTLFGKNGVQALDGQTHKHRKEMFMSIMSPDELEKLTDITKKQWEIAVDKWEQMD-- 134 Query: 163 TAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAG 222 +Y +M + ++ + + NL + L Sbjct: 135 -----KVILYEEAKEIMCRTACQW---AGVPVQENEVKRLTKNLGAMFESAAAV-GLKHW 185 Query: 223 LPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVV 282 L H E+L + +R + E+ + + + D D E A ++ Sbjct: 186 LGRHARNYEEIWIEELIDRVRDGKVNPPENTT--LHKFSWYRDLEGNLLDTETAAVEVIN 243 Query: 283 LWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELND 342 + + + PE + D Sbjct: 244 ILRPIVAIAIFINFIALALHHYPEEKEKLKS---------------------------GD 276 Query: 343 LPVLDSIIKESLRLSSA-SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIY 401 ++E R + K+DFT Y + + L + DPEI+ Sbjct: 277 KKYSQMFVQEVRRFYPFFPFVVALVKKDFTWK----GYKFEEGTLTLLDLYGTNHDPEIW 332 Query: 402 PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGA----TICPGRLFAIHEIKQF 457 +P F DR+ G + ++P G G C G I +K Sbjct: 333 KNPDVFSPDRFAKWEGS------------PFSFIPQGGGDYFMGHRCAGEWVTIEVMKVS 380 Query: 458 LILMLSYFELELIEGQ 473 L + + + E+ + Sbjct: 381 LDYLTNRMDYEVPDQD 396 >2ZQJ-A nrPDB Length = 417 Score = 96.9 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 65/474 (13%), Positives = 130/474 (27%), Gaps = 81/474 (17%) Query: 42 LGCALQFGANPLEFLRANQRKH-GHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKF 100 L +L F++ ++ +F +L+GK +T + ++ Sbjct: 11 LDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAKVFYDTDRFQRQNAL 70 Query: 101 HFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSN 160 FG +I MDG+ + F+ + L E M E + + ++ Sbjct: 71 PKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSLMTPPHQKRLAELMTEEWKAAVTRWEKAD 130 Query: 161 SKTAAWVTEGMYSFCYRVMFEAGY----LTIFGRDLTRRDTQKAHILNNLDNFKQFDKVF 216 ++ ++ + + ++ R +++ Sbjct: 131 E-------VVLFEEAKEILCRVACYWAGVPLKETEVKERADDFIDMVDAFGAVG------ 177 Query: 217 PALVAGLPIHMFRTAHNAREKLAESLRHEN----LQKRESISELISLRMFLNDTLSTFDD 272 P H R + + E+ L K S + L + + S D Sbjct: 178 -------PRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMAFHTQEDGSQLDS 230 Query: 273 LEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNP 332 A + VL I A + L ++L +P Sbjct: 231 RMAAIELINVL-----RPIVAISYFLVF-----------------------SALALHEHP 262 Query: 333 ICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQ 392 + + ++E R + + +K + L Sbjct: 263 KYKEWLRSGNSREREMFVQEVRRYYPFGPFLGAL---VKKDFVWNNCEFKKGTSVLLDLY 319 Query: 393 LMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGA----TICPGRL 448 + DP ++ P F+ +R+ + + +P G G CPG Sbjct: 320 GTNHDPRLWDHPDEFRPERFAEREENL------------FDMIPQGGGHAEKGHRCPGEG 367 Query: 449 FAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFK 502 I +K L F + IE L S A + LP + + K Sbjct: 368 ITIEVMKASL-----DFLVHQIEYDVPEQSLHYSLARMPSLPESGFVMSGIRRK 416 >5L94-A nrPDB Length = 410 Score = 96.9 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 46/257 (17%), Positives = 81/257 (31%), Gaps = 53/257 (20%) Query: 233 NAREKLAESLRHENLQKRESI-SELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTI 291 A ++L +KR ++IS+ + + D E +++L A T Sbjct: 189 KANDELETYFYRIIEEKRTRPGDDIISVLLQAKEEGKQLTDEEIVGFSILLLIAGNETTT 248 Query: 292 PATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIK 351 +++ ++ + + + E + +L S I+ Sbjct: 249 NLISNTIYCLMEDKASFERLKREKE----------------------------LLPSGIE 280 Query: 352 ESLRLS-SASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYD 410 E LR R KED TL ++ + + + H D E + DP FK D Sbjct: 281 EVLRYRSPVQALHRIVKEDVTL----AGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKID 336 Query: 411 RYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF-ELEL 469 R +M FG G C G A E K L ++ + +++ Sbjct: 337 R------------------KPNVHMAFGRGIHFCLGAPLARIEAKIMLAELIDRYPQMDW 378 Query: 470 IEGQAKCPPLDQSRAGL 486 P GL Sbjct: 379 SPSFELKPIESTFVYGL 395 >5CJE-A nrPDB Length = 393 Score = 94.6 bits (233), Expect = 9e-20, Method: Composition-based stats. Identities = 63/458 (13%), Positives = 119/458 (25%), Gaps = 88/458 (19%) Query: 44 CALQFGANPLEFLRANQRKHGHVFTCKLMGKYVH----FITNPLSYHKVLCHGKYFDWKK 99 +F +P + + G V + + + + + D K Sbjct: 10 YGARFTEDPYPVYAELRER-GPVHWVRTPPPEAFEGWLVVGHEEARAALADPRLSKDGTK 68 Query: 100 FHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSS 159 + + +D + + + +L + E ++ Sbjct: 69 KGLTSLDVELMGPYLLVVDPPEHTRLRSLVARAFTMRRVEALRPRIQEITDGLL------ 122 Query: 160 NSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKV-FPA 218 + + + SF Y + + D+V F A Sbjct: 123 DEMLPRGRADLVDSFAYPLPITVICELL--------------------GVPDIDRVTFRA 162 Query: 219 LVAGLPIHMFRTAHNAREKLAESLRHENLQKRESI----SELISLRMFLNDTLSTFDDLE 274 L + A A + + E + + S L L + E Sbjct: 163 LSNEIVAPTGGDAELAAYERLAAYLDELIDDKRSTAPADDLLGDLIRTRAEDDDRLSGEE 222 Query: 275 KAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPIC 334 ++L A T+ + ++ +P+ + A Sbjct: 223 LRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRA--------------------- 261 Query: 335 LSQAELNDLPVLDSIIKESLRLSSAS--LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQ 392 D+ +LD ++E LR R A E +E G I + D + + Sbjct: 262 -------DMTLLDGAVEEVLRFEGPVETATYRYAAES----MEIGGTAIAEGDPVMIGLD 310 Query: 393 LMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIH 452 DP +PDP F R ++ FG G C G A Sbjct: 311 AAGRDPARHPDPHVFDIHR------------------APQGHLAFGHGIHYCLGAPLARL 352 Query: 453 EIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILP 490 E + L +L ++G P G+ LP Sbjct: 353 EARVALRSLLERCPDLALDGPPGARPPGMLIRGVRRLP 390 >4YT3-A nrPDB Length = 410 Score = 93.8 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 54/392 (13%), Positives = 116/392 (29%), Gaps = 72/392 (18%) Query: 83 LSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDP-------MDGNTTENINDTFIKTLQG 135 +VL K+F + S P D Sbjct: 50 EDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVPEKIQITESDPPDHRKRRSLLAAAFTP 109 Query: 136 HALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRR 195 +L + + E ++ + T + + S ++ DL Sbjct: 110 RSLQNWEPRIQEIADELI---GQMDGGTEIDIVASLASPLPIIVM---------ADLMGV 157 Query: 196 DTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISE 255 ++ + D +F + + A ++ + L +QKR + ++ Sbjct: 158 PSKDRLLFKKW-----VDTLFLPFDREKQEEVDKLKQVAAKEYYQYLYPIVVQKRLNPAD 212 Query: 256 LISLRMFLNDT-LSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEE 314 I + ++ F D E +T +++L A T S + ++ + K +E Sbjct: 213 DIISDLLKSEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYD---DKEVYQE 269 Query: 315 VKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHL 374 + +L ++ ++E LR N+ Sbjct: 270 LHE------------------------NLDLVPQAVEEMLRFR---FNLIKLDRTVKEDN 302 Query: 375 EDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYY 434 + +++ D + ++ ++D E++ DP T R ++ + Sbjct: 303 DLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHRPNNKK-----------------H 345 Query: 435 MPFGSGATICPGRLFAIHEIKQFLILMLSYFE 466 + FG+G C G A E K L L F+ Sbjct: 346 LTFGNGPHFCLGAPLARLEAKIALTAFLKKFK 377 >5YHJ-A nrPDB Length = 413 Score = 92.6 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 59/468 (12%), Positives = 123/468 (26%), Gaps = 78/468 (16%) Query: 42 LGCALQFGANPLEFLRANQRKH-GHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKF 100 L ++ F F+ ++ ++F +L+G+ V + + K+ Sbjct: 11 LDHSVDFLREGYLFVANRRKSFQSNIFESRLLGERVICLGGEEAAEVFYDANKFTRQDAA 70 Query: 101 HFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSN 160 FG + +DG+ + F+ + ++ L +I R Sbjct: 71 PKRLLKTLFGEGGVQTLDGSEHTHRKQMFMSLMTKENIDRLLRLTYREWNQIERM----- 125 Query: 161 SKTAAWVTEGMYSFCYRVMFEAGYL----TIFGRDLTRRDTQKAHILNNLDNFKQFDKVF 216 +Y V+ +A + ++ +R + + + + Sbjct: 126 -----GEEIVLYDIAQEVLMKAVCEWSGVPLAKEEVGKRTEEMRLLFES-GTSLGPTYL- 178 Query: 217 PALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMF--LNDTLSTFDDLE 274 R A ++ E + E R +E +L F D E Sbjct: 179 ----------QGRKARSSAEVWIRQMVKEVRSNRLLPNEHTALYEFSWHRDESGELLPEE 228 Query: 275 KAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAA-TEEVKRTLENAGQKVSLEGNPI 333 ++ + +++ + + P+ + EV +T Sbjct: 229 VVAVEVLNILRPTVAISVYVLFTVLALHQFPDVKEQVERGEVSKT--------------- 273 Query: 334 CLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQL 393 ++E R A E Y + + L Sbjct: 274 --------------EFVQEVRRFYP---FFPVAAARVKTDFEWDGYAFPEGTLTLLDLYG 316 Query: 394 MHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHE 453 + D I+ +P F R+ D G + + C G I Sbjct: 317 TNHDVSIWTEPDRFDPSRFKDWKESPFNFIPQGGGDVDFG--------HRCAGEHVTI-- 366 Query: 454 IKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKF 501 L ++ F E PP D S +P L + + Sbjct: 367 --AILAQVIELFTKEY---AYTVPPQDLS-YSFVDMPSLPKSKLRLTH 408 >6HQG-A nrPDB Length = 425 Score = 91.9 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 60/420 (14%), Positives = 122/420 (29%), Gaps = 78/420 (18%) Query: 51 NPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFG 110 +P+ + + G ++ + TN H+V A F Sbjct: 48 DPVHWGVSPHEDVGGYWSVTKYNDIMAVDTN----HEVFS-----SEPTIVLPDPADDFT 98 Query: 111 HRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEG 170 MD + T + + L L + E +I+ WV + Sbjct: 99 LPMFIAMDPPKHDVQRKTVQPIVAPNHLAYLEPIIRERAGKILDDLPIGEE--INWVDKV 156 Query: 171 MYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVF----PALVAGLPIH 226 + T+F D D +K +++ + P L Sbjct: 157 SIELTTMTL-----ATLF--DFPWEDRRKLTFWSDVATSAPESGILGTTDPEEHENLRRQ 209 Query: 227 MFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWAS 286 + +L + + + + ++ D +E ++++ Sbjct: 210 TLFECVDYFMRLWNERVNAPPKPD------LISMLAHGESTKNMDRMEYLGNLILLIVGG 263 Query: 287 QANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL 346 T S+ + +NP+ + E NP + Sbjct: 264 NDTTRNTISGSVLALHQNPDQDRKLRE-----------------NPGLIP---------- 296 Query: 347 DSIIKESLRL-SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPL 405 +++ E++R + + R AK DF L G IR+ D +A++ + D E+ P Sbjct: 297 -AMVSETIRWQTPLAYMRRRAKRDFEL----GGKTIREGDKVAMWYVSGNRDEEVIDRPN 351 Query: 406 TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 + +R ++ FG G C G A ++K +L+ F Sbjct: 352 DYWIER-----------------PRVRQHLSFGFGVHRCVGNRLAELQLKIIWEEILARF 394 >4WPZ-A nrPDB Length = 397 Score = 91.9 bits (226), Expect = 7e-19, Method: Composition-based stats. Identities = 56/384 (14%), Positives = 102/384 (26%), Gaps = 80/384 (20%) Query: 89 LCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMEN 148 T + S+ MD + K + +L + E Sbjct: 57 FSSKVMATAAAAMSETETGKLMNESLVGMDAPEHTRLRKLVTKAFTARRVETLRPRITEL 116 Query: 149 LQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDN 208 + +++ + + + V RV+ + G +DT Sbjct: 117 VGQLL-DELETLPRPVDLVKNFSVPLPVRVI-----CELLGVPAGDQDT----------- 159 Query: 209 FKQFDKVFPALVAGLPIHMFRTAHN--AREKLAESLRHENLQKRESI-SELISLRMFLND 265 F A L + A L KRE+ +LIS + ++D Sbjct: 160 -------FHAWSNALLGDWQQVVEKEAATVSLVNYFGELIAVKRENPADDLISELIAISD 212 Query: 266 TLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQK 325 ST + E + +L A T L ++ NPE + Sbjct: 213 GDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNPEELDKLR------------- 259 Query: 326 VSLEGNPICLSQAELNDLPVLDSIIKESLRLSSA----SLNIRTAKEDFTLHLEDGSYNI 381 +P + E LR + R + L G + Sbjct: 260 ------------DNREAIP---KAVDELLRFVPLTTTGGIIPRLTTAEVELS---GGQVL 301 Query: 382 RKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGA 441 ++ + DPE++ D R + ++ FG+G Sbjct: 302 PAGAVVLPAVATANRDPEVFEDGERLNVTRENNP------------------HLAFGAGI 343 Query: 442 TICPGRLFAIHEIKQFLILMLSYF 465 C G A E+++ L +L Sbjct: 344 HHCLGAQLARIELQEALGAILDRM 367 >5XNT-A nrPDB Length = 411 Score = 91.1 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 48/358 (13%), Positives = 107/358 (29%), Gaps = 65/358 (18%) Query: 110 GHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTE 169 I D +L + + E ++ + +T + + Sbjct: 84 DKIKITEADPPEHRKRRSLLAAAFTPRSLQNWEPRIQEIADELIE---EMDEETEIDIVQ 140 Query: 170 GMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFR 229 + S ++ DL ++ + D +F + Sbjct: 141 SLASPLPIIVM---------SDLMGVPSKDRLLFKKW-----VDILFLPFDKEKQEEVNE 186 Query: 230 TAHNAREKLAESLRHENLQKRESISELISLRMFLNDT-LSTFDDLEKAKTHLVVLWASQA 288 A ++ + L +QKR + ++ I + + F D E +T +++L A Sbjct: 187 LKQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKAEVDGEMFTDDEVVRTTMLILGAGVE 246 Query: 289 NTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDS 348 T S + ++ + K +E+ +L ++ Sbjct: 247 TTSHLLANSFYSLLYD---DKEVYQELHE------------------------NLDLVPQ 279 Query: 349 IIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFK 408 ++E LR N+ + +++ + + ++ +LD E++ D T Sbjct: 280 AVEEMLRYR---FNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLN 336 Query: 409 YDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFE 466 R ++ ++ FG+G C G A E K L L F+ Sbjct: 337 IHRPNNKK-----------------HLTFGNGPHFCLGAPLARLEAKIALTTFLKKFK 377 >4UBS-A nrPDB Length = 393 Score = 90.3 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 67/432 (15%), Positives = 131/432 (30%), Gaps = 91/432 (21%) Query: 73 GKYVHFITNPLSYHKVLCHGKYFDWKKF--HFATSAKAFGHRS----IDPMDGNTTENIN 126 G+ V +T + +L + + AT+ + R+ + +D Sbjct: 36 GRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGVDDPEHRTQR 95 Query: 127 DTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLT 186 + + +L + E + ++ + + A V+ V+ Sbjct: 96 RMLVPSFTLKRAAALRPRIQETVDGLL-DAMEAQGPPAELVSAFALPLPSMVI-----CA 149 Query: 187 IFG---RDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLR 243 + G D ++Q + L +AR +L + L Sbjct: 150 LLGVPYADHDFFESQSRRL--------------------LRGPGIAEVQDARAQLDDYLY 189 Query: 244 HENLQKRESISE-LISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMI 302 +KR+ + L+ + T D E ++L A T F ++ Sbjct: 190 ALIDRKRKEPGDGLLDDLIQEQLNRGTVDRAELVSLATLLLIAGHETTANMISLGTFTLL 249 Query: 303 RNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLR-LSSASL 361 R+PE + E +P + ++E LR LS A Sbjct: 250 RHPEQLAELRAEP-------------------------GLMP---AAVEELLRFLSIADG 281 Query: 362 NIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKT 421 +R A ED +E IR D+ + +++ D + +P + R Sbjct: 282 LLRVATED----IEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHR---------- 327 Query: 422 TFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSY---FELELIEGQAKCPP 478 +++ FG G C G+ A E++ L + L + P Sbjct: 328 --------SARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADEIPFKP 379 Query: 479 LDQSRAGLGILP 490 D + G+ LP Sbjct: 380 GDTIQ-GMLELP 390 >5VWS-A nrPDB Length = 393 Score = 89.9 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 59/381 (15%), Positives = 113/381 (29%), Gaps = 67/381 (17%) Query: 87 KVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMM 146 ++L + F + +A+ FG I +D + +++++ + Sbjct: 51 QILGDYQTFSSDRTRLMPTAQGFGKGGITMIDPPEHRHQRRLITHAFTPQSISAMEPRIR 110 Query: 147 ENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNL 206 + ++ V Y V+ E + R L R + + L + Sbjct: 111 QIADHLLDELPGPEFDL---VEHFAYPLPVIVIAELLGVPPGDRHLFRTWSDRLMSLQ-V 166 Query: 207 DNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESI-SELISLRMFLND 265 +N+ + RT A ++ + LR +R +L++ + Sbjct: 167 ENYADP-------------ELARTVAAAMTEMNDYLREHCRSRRTHPRDDLLTRLVQAEV 213 Query: 266 TLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQK 325 D E T ++L A T ++ + +PEA KA Sbjct: 214 EGKRLDLEEVVNTASLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVR------------- 260 Query: 326 VSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDD 385 +P + + ++ESLRL S L T + I + Sbjct: 261 ----ADPSLIP-----------AALEESLRLRSPFLQAGRV---TTRDVTIAGETIPANR 302 Query: 386 IIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICP 445 + + + D +PDP F R ++ FG G C Sbjct: 303 FVMAWILSANHDDRRFPDPERFDLHR------------------QTTGHIAFGHGVHFCL 344 Query: 446 GRLFAIHEIKQFLILMLSYFE 466 G E + L +L F Sbjct: 345 GAQLGRLEGRIALERLLGRFT 365 >5IT1-A nrPDB Length = 399 Score = 89.2 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 57/399 (14%), Positives = 109/399 (27%), Gaps = 77/399 (19%) Query: 73 GKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAF----GHRSIDPMDGNTTENINDT 128 G +T VL + T G S+ D + Sbjct: 42 GHEAWLVTGYEQVRAVLRDPSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEHTDDRKL 101 Query: 129 FIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIF 188 K + +L ++ + + + + V V+ + +F Sbjct: 102 LAKEFTVRRMQALRPNIQRIVDEHL-DAIEARGGPVDLVKTFANPVPSMVISD-----LF 155 Query: 189 GRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQ 248 G RR F++ + + A A L ++ +Q Sbjct: 156 GVPAERRAE-----------FQEIAEAMMR------VDQDAAATEAAGMRLGGLLYQLVQ 198 Query: 249 KRESI--SELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPE 306 +R + +LIS + D DD+ +L A+ T ++ P+ Sbjct: 199 ERRANPGDDLISALITTEDPDGVIDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDRPD 258 Query: 307 AMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTA 366 + + +P ++ + ++E LR ++ A Sbjct: 259 QLALLQK-----------------DPS-----------LIGNAVEELLRY--LTIGQFGA 288 Query: 367 KEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCN 426 + T E G I K + + + DP DP F R Sbjct: 289 ERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITR--------------- 333 Query: 427 GLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 ++ FG GA C G+ A E++ + F Sbjct: 334 ---RPAPHLAFGFGAHQCIGQQLARIELQIVFGTLFRRF 369 >2Y5N-A nrPDB Length = 417 Score = 89.2 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 63/422 (14%), Positives = 120/422 (28%), Gaps = 80/422 (18%) Query: 73 GKYVHFITNPLSYHKVLCHGKYFDWKKF--HFATSAKAFGHRSIDPMDGNTTENINDTFI 130 G+ +T VL G++ + + MD + + Sbjct: 60 GEEAWLVTRYEDVRAVLGDGRFVRGPSMTRDEPRTRPEMVKGGLLSMDPPEHSRLRRLVV 119 Query: 131 KTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGR 190 K SL + + +++ + A V RV+ + G Sbjct: 120 KAFTARRAESLRPR-AREIAHELVDQMAATGQPADLVAMFARQLPVRVI-----CELLG- 172 Query: 191 DLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKR 250 + D F ++ F + M A A + + + +++ Sbjct: 173 ----------VPSADHDRFTRWSGAFLSTAEVTAEEMQEAAEQAYAYMGDLIDR---RRK 219 Query: 251 ESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKA 310 E +L+S + D + + E + +L A +T ++ ++ PE + Sbjct: 220 EPTDDLVSALVQARDQQDSLSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTRPELRRQ 279 Query: 311 ATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASL---NIRTAK 367 L+ ++ S ++E R + R A Sbjct: 280 L----------------------------LDRPELIPSAVEELTRWVPLGVGTAFPRYAV 311 Query: 368 EDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNG 427 ED TL IR + + + D +PD DR Sbjct: 312 EDVTL----RGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDR---------------- 351 Query: 428 LKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLG 487 ++ FG G C G A E++ L ++L + G P Q R G Sbjct: 352 --TPNQHLGFGHGVHHCLGAPLARVELQVALEVLLQR-----LPGIRLGIPETQLRWSEG 404 Query: 488 IL 489 +L Sbjct: 405 ML 406 >4JBT-A nrPDB Length = 410 Score = 87.6 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 59/423 (13%), Positives = 126/423 (29%), Gaps = 81/423 (19%) Query: 57 RANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCH---GKYFDWKKFHFATSA----KAF 109 + R G + L+G +T ++L K + + + Sbjct: 23 TSRLRAAGPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLI 82 Query: 110 GHRSID----PMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAA 165 G +D +DG + + L L++L ++ + ++ + + A Sbjct: 83 GMIDVDRSMFTVDGPEHRRLRIKTTQALTRRRLDALKPTIERYVAELLDDLERAGADGAV 142 Query: 166 WVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPI 225 + ++++ + + + + D +L F F L Sbjct: 143 VDLKSVFAYPLPMRVISALMGVPSEDQE-------QLLTWYKAF------FSILTPQD-- 187 Query: 226 HMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWA 285 R E +R + E +L S ++ D + + E ++ A Sbjct: 188 ERLRVIDEMHGYFTEMVRRKTA---EPGDDLTSALIYATDGETPLTEEEVIGNLQALVAA 244 Query: 286 SQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPV 345 T+ ++ ++ +PE ++ + Sbjct: 245 GHETTVSLILTAVRALLSHPEQLRLVR---DGEIGW------------------------ 277 Query: 346 LDSIIKESLRLSSAS--LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYP- 402 ++ I+E+LR L +R A ED L G I + + + + + + D ++ Sbjct: 278 -ETAIEETLRWDGPVIHLLMRFATEDIDL----GDAVIPRGEGVVMSYRAIGRDITVHGA 332 Query: 403 DPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILML 462 D F R ++ FG G ICPG A E L + Sbjct: 333 DADDFDITRATAAR-----------------HISFGHGPHICPGAALARLEAAIALPALF 375 Query: 463 SYF 465 + F Sbjct: 376 TRF 378 >4GGV-A nrPDB Length = 418 Score = 87.6 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 62/414 (14%), Positives = 116/414 (28%), Gaps = 64/414 (15%) Query: 78 FITNPLSYHKVLCHGKY-FDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGH 136 P + + H + D + + MD + Sbjct: 58 VYGYPEAMDILNDHDTFTSDLAHLLPVSVDAPLLEGDMSQMDPPRHRKYRQLVSRAFTPR 117 Query: 137 ALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRD 196 L M + I R + + ++ V+ A + G RD Sbjct: 118 ----LVADMETRVADITRELLDAVDGKPEIEIAADLAYPLPVIVIAE---LLGVPAGDRD 170 Query: 197 TQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESIS-E 255 K + ++ F F + +G R A L + + ++R + + Sbjct: 171 LFKKWADDIIEGFSGFSFL---DTSGQGEQDVRDATERLRPLLDYMAGHVTERRRTPRED 227 Query: 256 LISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEV 315 L++ + D E ++L T ++ + +PE Sbjct: 228 LLTHLVQAEVDGERLTDNEIVNVANILLVTGHITTTMTLGNTVLCLDADPEVAAKVR--- 284 Query: 316 KRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLR-LSSASLNIRTAKEDFTLHL 374 A+ + +P I+E+LR LS ++ R + + Sbjct: 285 ----------------------ADRSLVP---GAIEEALRVLSPSAALARGTSREVEV-- 317 Query: 375 EDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYY 434 I KD I+ L+ + DP + DP + R + Sbjct: 318 --AGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTR------------------DPNPH 357 Query: 435 MPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGI 488 FG G C G A E + L + F + L AK P + +G+ Sbjct: 358 FGFGRGIHFCLGAPLARLEGRVALNALFDRFPV-LRTDPAKPPTFFPTPDMIGV 410 >4RM4-A nrPDB Length = 396 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 51/354 (14%), Positives = 103/354 (29%), Gaps = 62/354 (17%) Query: 112 RSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGM 171 SI MD I K + + E +++ + V + Sbjct: 79 NSIINMDPPKHTKIRSVVNKAFTPRVMKQWEPRIQEITDELIQKFQGRSEFDL--VHDFS 136 Query: 172 YSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTA 231 Y V+ E + G + ++ ++L DK A A L Sbjct: 137 YPLPVIVISE-----LLG--VPSAHMEQFKAWSDLLVSTPKDKSEEAEKAFL--EERDKC 187 Query: 232 HNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTI 291 + E K E ++IS+ + +T E ++L A T Sbjct: 188 EEELAAFFAGIIEEKRNKPEQ--DIISILVEAEETGEKLSGEELIPFCTLLLVAGNETTT 245 Query: 292 PATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIK 351 +++ ++ P + + ++ ++ Sbjct: 246 NLISNAMYSILETPGVYEELR----------------------------SHPELMPQAVE 277 Query: 352 ESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDR 411 E+LR + + +R + E G + I++ D++ + + D + P F R Sbjct: 278 EALRFRAPAPVLRRIAK---RDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR 334 Query: 412 YLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 + + ++ FG G C G A E L ++S F Sbjct: 335 HPNP------------------HIAFGHGIHFCLGAPLARLEANIALTSLISAF 370 >3R9C-A nrPDB Length = 418 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 47/240 (19%), Positives = 83/240 (34%), Gaps = 52/240 (21%) Query: 238 LAESLRHENLQKRESIS-ELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFW 296 L + LR ++R + +L+S + + ++ + E T ++L A T+ Sbjct: 208 LRDYLRALIDERRRTPGEDLMSGLVAVEESGDQLTEDEIIATCNLLLIAGHETTVNLIAN 267 Query: 297 SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL 356 + M+R P A + R ++I+E++R Sbjct: 268 AALAMLRTPGQWAALAADGSRA----------------------------SAVIEETMRY 299 Query: 357 SSAS-LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDE 415 L R A +D T+ G++ + K D + L H DP I P F DR Sbjct: 300 DPPVQLVSRYAGDDLTI----GTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPDR---- 351 Query: 416 NGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAK 475 + ++ FG GA C G A E L + + F + G+ + Sbjct: 352 --------------AQIRHLGFGKGAHFCLGAPLARLEATVALPALAARFPEARLSGEPE 397 >2WIO-A nrPDB Length = 431 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 55/382 (14%), Positives = 105/382 (27%), Gaps = 67/382 (17%) Query: 111 HRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEG 170 I +D + ++ L + + + ++ S Sbjct: 104 PGMIHEIDPPEHRALRKVVSSAFTPRTISDLEPRIRDVTRSLLADAGESFDL------VD 157 Query: 171 MYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGL-PIHMFR 229 + +F V A L + D + +++ + + + L P+ + Sbjct: 158 VLAFPLPVTIVAELLGLPPMDHEQFGDWSGALVDIQMDDPTDPALAERIADVLNPLTAYL 217 Query: 230 TAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQAN 289 A A + + +LIS + DD E A +L A Sbjct: 218 KARCAERR------------ADPGDDLISRLVLAEVDGRALDDEEAANFSTALLLAGHIT 265 Query: 290 TIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSI 349 T + + +P AA E + +P +I Sbjct: 266 TTVLLGNIVRTLDEHPAHWDAAAE-------------------------DPGRIP---AI 297 Query: 350 IKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKY 409 ++E LR ++ T E I D ++ + + D + + DP F Sbjct: 298 VEEVLRYRPPFPQMQRT---TTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDP 354 Query: 410 DRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF-ELE 468 R + FG G C G A E + L +++ F L Sbjct: 355 SR----------------KSGGAAQLSFGHGVHFCLGAPLARLENRVALEEIIARFGRLT 398 Query: 469 LIEGQAKCPPLDQSRAGLGILP 490 + + +Q G LP Sbjct: 399 VDRDDERLRHFEQIVLGTRHLP 420 >2ZBZ-A nrPDB Length = 412 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 59/412 (14%), Positives = 119/412 (28%), Gaps = 85/412 (20%) Query: 64 GHVFTCKLM-GKYVHFITNPLSYHKVLCHGKYFDWKKFH-FATSAKAFGHRSIDPM---- 117 G + L G+ +T + K+L + + F ++ AF P Sbjct: 38 GPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPAFEAVRESPQAFIG 97 Query: 118 -DGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCY 176 D I + + + E + + +++ TA V++ Sbjct: 98 LDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAG-PTADLVSQFALPVPS 156 Query: 177 RVMFEAGYLTIFG---RDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHN 233 V+ + G D ++ + D ++A Sbjct: 157 MVI-----CRLLGVPYADHEFFQDASKRLVQSTDA--------------------QSALT 191 Query: 234 AREKLAESLRHENLQKRESISELISLRMFLNDT-LSTFDDLEKAKTHLVVLWASQANTIP 292 AR LA L Q + + + + D E T +++L A T Sbjct: 192 ARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIAGHETTAS 251 Query: 293 ATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKE 352 T S+ ++ +PE A A+ + +P ++E Sbjct: 252 MTSLSVITLLDHPEQYAALR-------------------------ADRSLVP---GAVEE 283 Query: 353 SLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRY 412 LR + + + +E IR + + + + + D +Y DP R Sbjct: 284 LLRYLAIADIAGGRVATADIEVE--GQLIRAGEGVIVVNSIANRDGTVYEDPDALDIHR- 340 Query: 413 LDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSY 464 +++ FG G C G+ A E++ L ++ Sbjct: 341 -----------------SARHHLAFGFGVHQCLGQNLARLELEVILNALMDR 375 >5XJN-A nrPDB Length = 455 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 50/346 (14%), Positives = 94/346 (27%), Gaps = 64/346 (18%) Query: 119 GNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRV 178 I K +L + R M M S Sbjct: 140 PPEHTRIRAIAQKAFTPRRYKALEPDI-----RAMVIDRVEKMLANDQHVGDMVSDLAYD 194 Query: 179 MFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKL 238 + LT+ G D++ DT K ++ + + ++ + + Sbjct: 195 IPTITILTLIGADISMVDTYK--RWSDSRAAMTWGDLSDEEQIPHAHNLVEYWQECQRMV 252 Query: 239 AESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSL 298 A++ H ++L+ + D E A +L+A T Sbjct: 253 ADAHAHGG---DNLTADLVRAQQ----EGQEITDHEIASLLYSLLFAGHETTTTLISNCF 305 Query: 299 FQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLS- 357 ++ +PE +A E + ++ + + E LR S Sbjct: 306 RVLLDHPEQWQAILE----------------------------NPKLIPAAVDEVLRYSG 337 Query: 358 SASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENG 417 S R A +D + G I++ D + L + D + + F R Sbjct: 338 SIVGWRRKALKDTEI----GGVAIKEGDGVLLLMGSANRDEARFENGEEFDISR------ 387 Query: 418 KTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLS 463 ++ FG G C G + A + K L + Sbjct: 388 -----------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEVTR 422 >5GWE-A nrPDB Length = 405 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 50/346 (14%), Positives = 94/346 (27%), Gaps = 64/346 (18%) Query: 119 GNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRV 178 I K +L + R M M S Sbjct: 90 PPEHTRIRAIAQKAFTPRRYKALEPDI-----RAMVIDRVEKMLANDQHVGDMVSDLAYD 144 Query: 179 MFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKL 238 + LT+ G D++ DT K ++ + + ++ + + Sbjct: 145 IPTITILTLIGADISMVDTYK--RWSDSRAAMTWGDLSDEEQIPHAHNLVEYWQECQRMV 202 Query: 239 AESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSL 298 A++ H ++L+ + D E A +L+A T Sbjct: 203 ADAHAHGG---DNLTADLVRAQQ----EGQEITDHEIASLLYSLLFAGHETTTTLISNCF 255 Query: 299 FQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLS- 357 ++ +PE +A E + ++ + + E LR S Sbjct: 256 RVLLDHPEQWQAILE----------------------------NPKLIPAAVDEVLRYSG 287 Query: 358 SASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENG 417 S R A +D + G I++ D + L + D + + F R Sbjct: 288 SIVGWRRKALKDTEI----GGVAIKEGDGVLLLMGSANRDEARFENGEEFDISR------ 337 Query: 418 KTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLS 463 ++ FG G C G + A + K L + Sbjct: 338 -----------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEVTR 372 >5OFQ-A nrPDB Length = 409 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 58/408 (14%), Positives = 123/408 (30%), Gaps = 68/408 (16%) Query: 79 ITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHAL 138 + + + +L + F K+ MD + + K A+ Sbjct: 54 VFDYETVKYILKNPSLFSSKRAMEERQESILM------MDPPKHTKLRNLVNKAFTPRAI 107 Query: 139 NSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQ 198 L + E + + VSS K V + V+ E + I R L ++ + Sbjct: 108 QHLEGHI-EEIADYLLDEVSSKEKFDI-VEDFAGPLPIIVIAELLGVPIQDRALFKKYSD 165 Query: 199 KAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELIS 258 +++ +N D+ F ++ + +E +AE +++ +LIS Sbjct: 166 --DLVSGAEN--NSDEAFAKMMQKRNEGVIFLQGYFKEIIAERQQNK-------QEDLIS 214 Query: 259 LRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRT 318 L + + E +++L A T + M + + ++ Sbjct: 215 LLLEAEIDGEHLTEEEVLGFCILLLVAGNETTTNLITNGVRYMTEDVDVQNEVRRDIS-- 272 Query: 319 LENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGS 378 ++ ++++E+LR I + +E G Sbjct: 273 --------------------------LVPNLVEETLRYYPPIQAIGRIAAE---DVELGE 303 Query: 379 YNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFG 438 I++ + + + D + P TF R + ++ FG Sbjct: 304 CKIKRGQQVISWAASANRDSAKFEWPDTFVVHRKTNP------------------HVSFG 345 Query: 439 SGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGL 486 G C G A E K +L ++ Q+ P G+ Sbjct: 346 FGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDSPFVFGV 393 >1ODO-A nrPDB Length = 408 Score = 86.5 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 61/440 (13%), Positives = 127/440 (28%), Gaps = 87/440 (19%) Query: 58 ANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSID-- 115 R+ G ++G +++P+ ++L + H+ + G + Sbjct: 22 RTLREGGPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDARAHWPAFGEVVGTWPLALW 81 Query: 116 -------PMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVT 168 G + ++++ ++ + ++ + + Sbjct: 82 VAVENMFTAYGPNHRKLRRLVAPAFSARRVDAMRPAVEAMVTGLVDRLAELPAGEPVDLR 141 Query: 169 -EGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHM 227 E Y V+ + G RRD +A + D Sbjct: 142 QELAYPLPIAVIGH-----LMGVPQDRRDGFRALVDGVFDTTL----------------D 180 Query: 228 FRTAHNAREKLAESLRHENLQKRESISE----LISLRMFLNDTLSTFDDLEKAKTHLVVL 283 A +L E L KR + + L+ E T L+++ Sbjct: 181 QAEAQANTARLYEVLDQLIAAKRATPGDDMTSLLIAARDDEGDGDRLSPEELRDTLLLMI 240 Query: 284 WASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDL 343 A T+ ++ ++ P+ + + ++ A+ Sbjct: 241 SAGYETTVNVIDQAVHTLLTRPDQLALVRK-------------------GEVTWAD---- 277 Query: 344 PVLDSIIKESLRLSSAS--LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIY 401 +++E+LR A L +R A D L I + + I + P+ + Sbjct: 278 -----VVEETLRHEPAVKHLPLRYAVTDIALPDGRT---IARGEPILASYAAANRHPDWH 329 Query: 402 PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILM 461 D TF R + E ++ FG G C G A E+ L + Sbjct: 330 EDADTFDATRTVKE------------------HLAFGHGVHFCLGAPLARMEVTLALESL 371 Query: 462 LSYF-ELELIEGQAKCPPLD 480 F +L L + + PP+ Sbjct: 372 FGRFPDLRLADPAEELPPVP 391 >1CPT-A nrPDB Length = 428 Score = 85.7 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 39/214 (18%), Positives = 80/214 (37%), Gaps = 51/214 (23%) Query: 254 SELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATE 313 +++SL + DD ++ + A T ++ ++ + RNPE + Sbjct: 236 DDVMSLLANSKLDGNYIDDKYINAYYVAIATAGHDTTSSSSGGAIIGLSRNPEQLA---- 291 Query: 314 EVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLS-SASLNIRTAKEDFTL 372 L++++ +P L + E++R + +RTA D + Sbjct: 292 ---------------------LAKSDPALIPRL---VDEAVRWTAPVKSFMRTALADTEV 327 Query: 373 HLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKY 432 ++ I++ D I L + D E++ +P F R+ + Sbjct: 328 RGQN----IKRGDRIMLSYPSANRDEEVFSNPDEFDITRFPNR----------------- 366 Query: 433 YYMPFGSGATICPGRLFAIHEIKQFLILMLSYFE 466 ++ FG GA +C G+ A E+K F +L + Sbjct: 367 -HLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLK 399 >2Z36-A nrPDB Length = 413 Score = 85.3 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 55/420 (13%), Positives = 116/420 (27%), Gaps = 85/420 (20%) Query: 58 ANQRKHGHVFTCKLM-GKYVHFITNPLSYHKVLCHGKYFDWKKFH----FATSAKAFGHR 112 R+ + +L G +++ VL G++ K+ F A Sbjct: 29 ERLRERAPINKVRLTSGGQAWWVSGHEEARAVLADGRFSSDKRKDGFPLFTLDAATLQQL 88 Query: 113 SIDP-----MDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWV 167 P MDG I L +L + + + + ++++ + V Sbjct: 89 RSQPPLMLGMDGAEHSAARRPVIGEFTVKRLAALRPRIQDIVDHFIDDMLATDQRPVDLV 148 Query: 168 TEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHM 227 V+ + G + D + + Sbjct: 149 QALSLPVPSLVI-----CELLG--VPYTDHDFFQSRTTM---------------MVSRTS 186 Query: 228 FRTAHNAREKLAESLRHENLQKRESI-SELISLRMFLNDTLSTFDDLEKAKTHLVVLWAS 286 A +L + +K +L S ++ T D ++L A Sbjct: 187 MEDRRRAFAELRAYIDDLITRKESEPGDDLFSRQIARQRQEGTLDHAGLVSLAFLLLTAG 246 Query: 287 QANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL 346 T + ++ +P E++ N G+ Sbjct: 247 HETTANMISLGVVGLLSHP-------EQLTVVKANPGRTP-------------------- 279 Query: 347 DSIIKESLRLSSAS--LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDP 404 ++E LR + + + R A ED + G +I+ + + + + DP ++ DP Sbjct: 280 -MAVEELLRYFTIADGVTSRLATEDVEI----GGVSIKAGEGVIVSMLSANWDPAVFKDP 334 Query: 405 LTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSY 464 +R +++ FG G C G+ A E++ + Sbjct: 335 AVLDVER------------------GARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRR 376 >6GMF-A nrPDB Length = 397 Score = 85.3 bits (209), Expect = 6e-17, Method: Composition-based stats. Identities = 59/420 (14%), Positives = 115/420 (27%), Gaps = 73/420 (17%) Query: 50 ANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAF 109 NP +R +L + + +VL K F + + + Sbjct: 14 RNPYALFAELRRTSA---VGRLQPQGFMAVGRYQDVARVLHDAKGFSNRGWAASLPRGVK 70 Query: 110 GHRSIDP----MDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAA 165 S+ P +D + K + L + + ++ ++ A Sbjct: 71 WDTSMPPSIVQVDPPRHGKLRTLVTKAFTPRTVAQLEPRIRDIAHELVDGLRGKSTFEAT 130 Query: 166 WVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPI 225 + ++ A L + R +++ +V Sbjct: 131 ----VEVTVPMPMIVIAEMLGV----APERRADFKRWSDDMVGSLALVRV---------G 173 Query: 226 HMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWA 285 + + + +E A ++RE +LIS + E +L A Sbjct: 174 NAAQLERSTQEFYAYFSEVLEERRREPREDLISQLLAAEVDGEKLTAGEVLSFANTLLIA 233 Query: 286 SQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPV 345 T +L + +PE + AA DL + Sbjct: 234 GNETTTSLIGNALVALTDHPEQLAAAQA----------------------------DLSL 265 Query: 346 LDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPL 405 + ++++E LR S + I +E G I ++ + D +PDP Sbjct: 266 VPAVVEEVLRYESPAQCIFRQ---TMTDVEIGDERIPARSVVLPLLASANRDESRFPDPD 322 Query: 406 TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 F R ++ FG C G A E K L ++L+ Sbjct: 323 RFDIHR------------------DTKGHLAFGLDIHFCIGAPLARLEAKVMLEVLLARL 364 >3ABA-A nrPDB Length = 403 Score = 85.3 bits (209), Expect = 6e-17, Method: Composition-based stats. Identities = 53/397 (13%), Positives = 115/397 (28%), Gaps = 79/397 (19%) Query: 110 GHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTE 169 G S+ D + K + +L ++ + + ++ A Sbjct: 83 GRGSLLWQDEPEHTSDRKLLAKEFTVRRMQALRPNIQRIVDEHL------DAIEARGGPV 136 Query: 170 GMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFR 229 + + +FG + RR F+ + + Sbjct: 137 DLVKTFANAVPSMVISDLFGVPVERRAE-----------FQDIAEAMMR------VDQDA 179 Query: 230 TAHNAREKLAESLRHENLQKRESI--SELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQ 287 A A L ++ +Q+R + +LIS + D DD+ +L A+ Sbjct: 180 AATEAAGMRLGGLLYQLVQERRANPGDDLISALITTEDPDGVVDDMFLMNAAGTLLIAAH 239 Query: 288 ANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLD 347 T ++ +P+ + E +P ++ Sbjct: 240 DTTACMIGLGTALLLDSPDQLALLRE-----------------DPS-----------LVG 271 Query: 348 SIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTF 407 + ++E LR ++ + T +E G I K + + + DP +P F Sbjct: 272 NAVEELLRY--LTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERF 329 Query: 408 KYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFEL 467 R ++ FG GA C G+ A E++ + Sbjct: 330 DITR------------------RPAPHLAFGFGAHQCIGQQLARIELQIVFETLFRR--- 368 Query: 468 ELIEGQAKCPPLDQSRA-GLGILPPLNDIEFKYKFKH 503 + G P+++ R + ++++ + H Sbjct: 369 --LPGLRLAKPVEELRFRHDMVFYGVHELPVTWHHHH 403 >6DCD-A nrPDB Length = 424 Score = 84.2 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 68/476 (14%), Positives = 135/476 (28%), Gaps = 86/476 (18%) Query: 31 EPPLENGLIPYLGCAL---------QFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITN 81 +P L PY Q+G + + + + Sbjct: 12 DPSLIPDPHPYFDYLRSQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFS----NCVALGG 67 Query: 82 PLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSL 141 P +G + + + H MD + L L Sbjct: 68 PFPPLPFAPNGDDVNAQIDAHREQFPMYEHMV--TMDPPEHSRARSILSRLLTPSRLKQN 125 Query: 142 TESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAH 201 E M R + + + Y+ + + A + G + D + Sbjct: 126 EEFMWRLADRQLDEFLGAGECEFI----SEYAKPFATLVIAD---LLG--VPEDDRKDFR 176 Query: 202 ILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRM 261 ++ D + + V P+ K + + Q R + ++ Sbjct: 177 VVLGADRMGRVGALDHESVGVNPLQWLDD------KFSAYIEDRRRQPRNDVLTALATAT 230 Query: 262 FLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLEN 321 + + ST + ++ ++ + A Q T ++ + P+ + E Sbjct: 231 YPDG--STPEVIDVVRSATFLFAAGQETTAKLLTAAMRVLGDRPDIQRRLRE-------- 280 Query: 322 AGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL-SSASLNIRTAKEDFTLHLEDGSYN 380 + +P + I+ESLR+ S + R A++ T+ G + Sbjct: 281 -----------------NRSLIP---NFIEESLRMDSPVKSDSRLARKRTTV----GGLD 316 Query: 381 IRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSG 440 I ++ + P + DP + DP F+ DR +M F G Sbjct: 317 IAAGTVVMVLPGAANRDPRRFEDPHEFRLDR-----------------PNVREHMAFARG 359 Query: 441 ATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIE 496 CPG A E + L +L L++ + + P D R P + Sbjct: 360 VHSCPGGPLARVEGRVSLERILDRM-LDIAINEDRHGPADDRRYTY---EPTYILR 411 >3ABB-A nrPDB Length = 408 Score = 83.4 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 53/259 (20%), Positives = 90/259 (34%), Gaps = 59/259 (22%) Query: 248 QKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEA 307 ++ E L+ + D E LV+L A T+ A +I++P Sbjct: 206 KQAEPEDGLLDELIARQLEEGDLDHDEVVMIALVLLVAGHETTVNAIALGALTLIQHP-- 263 Query: 308 MKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS-LNIRTA 366 E++ L + G +++E LR +S S +R A Sbjct: 264 -----EQIDVLLRDPGAVSG---------------------VVEELLRFTSVSDHIVRMA 297 Query: 367 KEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCN 426 KED +E G I+ D + + LM+ D + Y +P F R Sbjct: 298 KED----IEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARR--------------- 338 Query: 427 GLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD--QSRA 484 +++ FG G C G+ A E++ L + + I G PLD +A Sbjct: 339 ---NARHHVGFGHGIHQCLGQNLARAELEIALGGLFAR-----IPGLRLAVPLDEVPIKA 390 Query: 485 GLGILPPLNDIEFKYKFKH 503 G P+ ++ + H Sbjct: 391 GHDAQGPI-ELPVVWHHHH 408 >3RWL-A nrPDB Length = 426 Score = 82.6 bits (202), Expect = 4e-16, Method: Composition-based stats. Identities = 46/351 (13%), Positives = 100/351 (28%), Gaps = 67/351 (19%) Query: 117 MDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCY 176 MD + + L +L ++ E + + + WV Sbjct: 114 MDRPRHDEQRKAVSPIVAPANLAALEGTIRERVSKTLDGLPVGEEF--DWVDRVSIEITT 171 Query: 177 RVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNARE 236 +++ T+F D + +K +++ V + + Sbjct: 172 QML-----ATLF--DFPFEERRKLTRWSDVTTAAPGGGVVESWDQR--KTELLECAAYFQ 222 Query: 237 KLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFW 296 L +++ + + + E L+++ T + Sbjct: 223 VLWNERVNKDPGND------LISMLAHSPATRNMTPEEYLGNVLLLIVGGNDTTRNSMTG 276 Query: 297 SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL 356 + + +NP+ NP ++++++ E +R Sbjct: 277 GVLALHKNPDQFAKLK-----------------ANPA-----------LVETMVPEIIRW 308 Query: 357 -SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDE 415 + + RTA D L G IRK D + ++ + D E+ P F DR Sbjct: 309 QTPLAHMRRTAIADSEL----GGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR---- 360 Query: 416 NGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFE 466 ++ FG G C G A +++ +L+ F Sbjct: 361 -------------PRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFS 398 >3TYW-A nrPDB Length = 417 Score = 82.2 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 46/349 (13%), Positives = 103/349 (29%), Gaps = 73/349 (20%) Query: 118 DGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYR 177 D + + ++ ++ + I+ + AA + S Sbjct: 103 DAPEHTRYRRMLLPAFTVRRVRAMRPAVQARVDEILDGML------AAGGPVDLVSAYAN 156 Query: 178 VMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREK 237 + + + G + R D + + + + + + + Sbjct: 157 AVSTSVICELLG--IPRHDLEFFRDVTRISGSRN------STAEQVSEALGGLFGLLGGL 208 Query: 238 LAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWS 297 +AE + + IS+L++ + + + + T + + A + T S Sbjct: 209 VAERREE---PRDDLISKLVTDHLVPGNVTT----EQLLSTLGITINAGRETTTSMIALS 261 Query: 298 LFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLS 357 ++ PE + + +P + + E LR+ Sbjct: 262 TLLLLDRPELPAELR-------------------------KDPDLMP---AAVDELLRVL 293 Query: 358 SAS--LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDE 415 S + + +R A ED L + DD + + DPE + DP + R Sbjct: 294 SVADSIPLRVAAEDIELS----GRTVPADDGVIALLAGANHDPEQFDDPERVDFHR---- 345 Query: 416 NGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSY 464 +++ FG G C G+ A E++ L +L Sbjct: 346 --------------TDNHHVAFGYGVHQCVGQHLARLELEVALETLLRR 380 >5FOI-A nrPDB Length = 408 Score = 82.2 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 55/396 (13%), Positives = 113/396 (28%), Gaps = 77/396 (19%) Query: 73 GKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAK---AFGHRSIDPMDGNTTENINDTF 129 G ++ +L + S G RS+ +D + F Sbjct: 55 GSPTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMF 114 Query: 130 IKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFG 189 I + ++ + + + I+ ++ +T +V+ + G Sbjct: 115 ISAFSVRQVETMRPEIEKIVDGILDRLLAL-EPPVDILTHLALPMSTQVI-----CHLLG 168 Query: 190 RDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQK 249 + D + + L + D+ PAL+ +L E L K Sbjct: 169 --VPYEDREFFQERSELASRPNDDRSMPALI----------------ELVEYLDGLVRTK 210 Query: 250 RESISE-LISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAM 308 L+ + E +++L A + S+ ++R+PE Sbjct: 211 TAHPDTGLLGTAVTERLLKGEITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETA 270 Query: 309 KAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKE 368 E+ + ++ + + E LR S + +R A Sbjct: 271 AELREQPE----------------------------LMPNAVDELLRYHSIADGLRRA-- 300 Query: 369 DFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGL 428 T + G + IR D + + + D + TF R Sbjct: 301 -ATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHR----------------- 342 Query: 429 KLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSY 464 +++ FG G C G+ A E++ L + Sbjct: 343 -PARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFRR 377 >6GK6-A nrPDB Length = 411 Score = 81.8 bits (200), Expect = 7e-16, Method: Composition-based stats. Identities = 51/393 (12%), Positives = 116/393 (29%), Gaps = 74/393 (18%) Query: 76 VHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQG 135 V + +P +++ + F + + D + + Sbjct: 54 VELLKDPRLIRDFRKLPDEV-RRRYFPLSDRTTFMDQHMLDADPPDHTRLRAIVQRAFSP 112 Query: 136 HALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRR 195 + L + E ++ + + + + + + V+ E + G + R Sbjct: 113 RMMEGLRPRIQEIADGLIDAVI--DRRRMELIADFAFPLPTAVIAE-----LLGLPVEDR 165 Query: 196 DTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAES-LRHENLQKRESIS 254 F+++ K+ L A E+ A + +++ Sbjct: 166 GR-----------FRRWTKIL--LAPAKDREFVERAQPVVEEFAAYFRALADARRKAPRD 212 Query: 255 ELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEE 314 +LIS + + E + ++L A T+ + ++ +P Sbjct: 213 DLISGLLLAEEQEHKLSPAELSSMVFLLLVAGHETTVHLIASGMLLLLSHP--------- 263 Query: 315 VKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS--LNIRTAKEDFTL 372 ++ L+ +P ++ S ++E+LR + IR + ED Sbjct: 264 --------AERRRLDEDPG-----------LVGSAVEEALRCEGPAELSTIRWSLED--- 301 Query: 373 HLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKY 432 +E + + +A + DP+ +PDP F R Sbjct: 302 -IELFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGR------------------SPN 342 Query: 433 YYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 ++ FG G C G + A E +L Sbjct: 343 RHIGFGGGIHFCLGAMLARIEAAIAFSTLLRRL 375 >5YSW-A nrPDB Length = 441 Score = 81.5 bits (199), Expect = 9e-16, Method: Composition-based stats. Identities = 65/451 (14%), Positives = 121/451 (26%), Gaps = 91/451 (20%) Query: 64 GHVFTCKLM-GKYVHFITNPLSYHKVLCHGKYFDWK---KFHFATSAKAFGHR------- 112 G V L G ++ VL ++ + F + F R Sbjct: 64 GPVARATLAAGDPFWLVSGYEEARAVLSDPRFSSDRFQYHPWFKELSPEFRERLRDDKAR 123 Query: 113 --SIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEG 170 S MD + L + E + + + + TA +TE Sbjct: 124 AGSFINMDPPEHTRYRKLLTGQFTVRRIRELGARIDEIVAGRV-DAMLAGGTTADLMTEF 182 Query: 171 MYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRT 230 + ++ + G R F+Q + A + + Sbjct: 183 AFPAPSLMI-----CELLGVRYEDRAE-----------FQQRASALLQMNAPV-AEAVKN 225 Query: 231 AHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANT 290 A R + + + ++IS + D E ++L A T Sbjct: 226 ADALRAFMQALVTDKRA---NPAGDIISGLIHHAGADPALTDDELINIANLLLIAGYDTT 282 Query: 291 IPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSII 350 +F +++ P + ++ R + + Sbjct: 283 ASMLGLGIFVLLQRPAQLATLRDDPSRIADA----------------------------V 314 Query: 351 KESLRLSSA--SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFK 408 +E LR S R AKED LE +I + + + D +PDP Sbjct: 315 EELLRYLSVVNPGIFRFAKED----LEFAGEHIPAGSTVVVSVVATNRDARHWPDPD--- 367 Query: 409 YDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF--- 465 + + + ++ FG G C G+ A E++ +L Sbjct: 368 ----------------LDLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNV 411 Query: 466 ELELIEGQAKCPPLDQSRAGLGILPPLNDIE 496 L + + D G+ LP D Sbjct: 412 RLAVPPEEVPLRN-DMLTYGVHSLPIAWDAP 441 >6F0B-A nrPDB Length = 395 Score = 81.1 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 60/427 (14%), Positives = 116/427 (27%), Gaps = 80/427 (18%) Query: 73 GKYVHFITNPLSYHKVLCHGKYF-DWKKFHFATSAKAFGHRSIDPMD----GNTTENIND 127 G H + VL ++ D ++ +F ++ P + Sbjct: 37 GTPAHVFSGYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHRRLRG 96 Query: 128 TFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTI 187 T + + L ++ E +Q ++ + T+ Sbjct: 97 TIAREFLPKHIELLRPAIREIVQGVLDGLAETAPPQ---------DMLEAFAVPVASATV 147 Query: 188 FGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENL 247 F R L +A + + +FRT L + Sbjct: 148 F-RLLGIPAEDRALLTRCVKGVVSAVG-----SEDEGAEVFRTLGEYIGGL--------V 193 Query: 248 QKRESISELISLRMFLNDTL--STFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNP 305 Q + E +R + E L+++ T SL P Sbjct: 194 QDPSELPEDSLIRRLVTGPYQEKQLTFHETIGVILMLIVGGYDTTASTISLSLVSYALQP 253 Query: 306 EAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRT 365 E E +R P+L ++E LR + S Sbjct: 254 EKFSVVHEHPERI-------------------------PLL---VEELLRYHTVSQL--G 283 Query: 366 AKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYC 425 T +E G +R ++ L + D ++P+P +DR Sbjct: 284 LGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR-------------- 329 Query: 426 NGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPL--DQSR 483 ++ FG G C G+ A E+++ + ++ + + P D + Sbjct: 330 ----PSVPHVGFGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLACALEDLPFRHDMAT 385 Query: 484 AGLGILP 490 G+ LP Sbjct: 386 YGIHELP 392 >1EHE-A nrPDB Length = 403 Score = 81.1 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 60/403 (14%), Positives = 121/403 (30%), Gaps = 80/403 (19%) Query: 97 WKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPP 156 + + + A + MD + T A+ +L + + ++ Sbjct: 69 FPELSASGKQAAKAKPTFVDMDPPEHMHQRSMVEPTFTPEAVKNLQPYIQRTVDDLLEQM 128 Query: 157 VSSN--SKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDK 214 + V E +++ T+ G N+L+ Q + Sbjct: 129 KQKGCANGPVDLVKEFALPVPSYIIY-----TLLG-----------VPFNDLEYLTQQNA 172 Query: 215 VFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTL-STFDDL 273 + R A A ++L + L Q+ + I ++ D Sbjct: 173 -----IRTNGSSTAREASAANQELLDYLAILVEQRLVEPKDDIISKLCTEQVKPGNIDKS 227 Query: 274 EKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPI 333 + + ++L A A + + + ++P+ + NP Sbjct: 228 DAVQIAFLLLVAGNATMVNMIALGVATLAQHPDQLAQLK-----------------ANPS 270 Query: 334 CLSQAELNDLPVLDSIIKESLRLS--SASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYP 391 Q ++E R SA RTAKED + G +R ++ I Sbjct: 271 LAPQ-----------FVEELCRYHTASALAIKRTAKEDVMI----GDKLVRANEGIIASN 315 Query: 392 QLMHLDPEIYPDPLTFKYDR-YLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA 450 Q + D E++ +P F +R + ++ + FG G C A Sbjct: 316 QSANRDEEVFENPDEFNMNRKWPPQDP-----------------LGFGFGDHRCIAEHLA 358 Query: 451 IHEIKQFLILMLSYF---ELELIEGQAKCPPLDQSRAGLGILP 490 E+ + F ++ + G+ PL+ G+ LP Sbjct: 359 KAELTTVFSTLYQKFPDLKVAVPLGKINYTPLN-RDVGIVDLP 400 >5Y1I-A nrPDB Length = 403 Score = 80.7 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 61/416 (14%), Positives = 118/416 (28%), Gaps = 74/416 (17%) Query: 78 FITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHA 137 +++P H L G F F + A S D I Sbjct: 56 LLSDPRVSHDGLRDGYPHISADFKFLSMA----QPSFAGQDDPEHGRIRRMVTLPFTARR 111 Query: 138 LNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDT 197 + ++ ++ + + + + + K V RV+ E + R+ +++ Sbjct: 112 IEAMRPAIQK-ITDELIDGMLAGPKPVDLVEALALPVPVRVICEMLGVPYEDREFLQQNN 170 Query: 198 QKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELI 257 A I + + A A+ + L L R + I Sbjct: 171 -NAMIYRDT-----------------AQGDAQKAAIAQAMYLKELVGTKLGDR---GDDI 209 Query: 258 SLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKR 317 + + + A +++L A T ++ NPE + + Sbjct: 210 LSDLAVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPEQLAEVRD---- 265 Query: 318 TLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDG 377 +P + + ++E LR + + T + +E G Sbjct: 266 -----------SDDPKVIV-----------NTVEELLRYLTIA--QDTVRRIAAEDIEIG 301 Query: 378 SYNIRKDDIIALYPQLMHLDPEIYPD-PLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMP 436 I+ + I + DP++YP+ P R ++ Sbjct: 302 GVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHR-----------------ANARRHLA 344 Query: 437 FGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPL--DQSRAGLGILP 490 FG G C G A E++ +L + G P DQ G+ LP Sbjct: 345 FGYGVHQCLGATLARVELQIVYSTLLRRIPTLALAGTLDEIPFKHDQIAHGVYELP 400 >1Q5D-A nrPDB Length = 419 Score = 80.7 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 55/462 (11%), Positives = 129/462 (27%), Gaps = 86/462 (18%) Query: 48 FGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAK 107 + +P + + +F +T V ++ ++ +++ Sbjct: 24 YAEDPFPAIERLREA-TPIFYWDEG--RSWVLTRYHDVSAVFRDERFAVSREEWESSAEY 80 Query: 108 A--------FGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSS 159 + + + + + A++ L + + +++ Sbjct: 81 SSAIPELSDMKKYGLFGLPPEDHARVRKLVNPSFTSRAIDLLRAEIQRTVDQLLDARSGQ 140 Query: 160 NSKTA-AWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPA 218 EG+ + + R + A L Sbjct: 141 EEFDVVRDYAEGIPMRAISALLKVPAEC--DEKFRRFGSATARALGV------------G 186 Query: 219 LVAGLPIHMFRTAHNAREKLAESLRHENLQKRESI---SELISLRMFLNDTLSTFDDLEK 275 LV + + E L +L H L +R ++++++ + S E Sbjct: 187 LVPRVDEETKTLVASVTEGL--ALLHGVLDERRRNPLENDVLTMLLQAEADGSRLSTKEL 244 Query: 276 AKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICL 335 ++ A TI +++ ++R+PEA++ E Sbjct: 245 VALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAEPG------------------- 285 Query: 336 SQAELNDLPVLDSIIKESLRLSSAS--LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQL 393 ++ + + E LR + +R A++D +I+K +++ L Sbjct: 286 ---------LMRNALDEVLRFDNILRIGTVRFARQDLEYC----GASIKKGEMVFLLIPS 332 Query: 394 MHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHE 453 D ++ P F R + +G G +CPG A E Sbjct: 333 ALRDGTVFSRPDVFDVRR------------------DTSASLAYGRGPHVCPGVSLARLE 374 Query: 454 IKQFLILMLSYF---ELELIEGQAKCPPLDQSRAGLGILPPL 492 + + + F +L+ P + IL P Sbjct: 375 AEIAVGTIFRRFPEMKLKETPVFGYHPAFRNIESLNVILKPS 416 >5HDI-A nrPDB Length = 404 Score = 80.7 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 32/197 (16%), Positives = 56/197 (28%), Gaps = 48/197 (24%) Query: 268 STFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVS 327 D L + + A +T +++ + P+ + Sbjct: 227 GELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRA-------------- 272 Query: 328 LEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDII 387 + +L + I+E+LR + T + D + Sbjct: 273 --------------NPELLGAFIEETLRYEPPFRGHYRHVRNAT---TLDGTELPADSHL 315 Query: 388 ALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGR 447 L + DP + P F+ DR GK ++ FG GA C G Sbjct: 316 LLLWGAANRDPAQFEAPGEFRLDR---AGGK--------------GHISFGKGAHFCVGA 358 Query: 448 LFAIHEIKQFLILMLSY 464 A E + L L+L Sbjct: 359 ALARLEARIVLRLLLDR 375 >6B11-A nrPDB Length = 440 Score = 80.3 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 56/430 (13%), Positives = 113/430 (26%), Gaps = 78/430 (18%) Query: 73 GKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSA---KAFGHRSIDPMDGNTTENINDTF 129 G V I+ +L + S +A RS+ +D + F Sbjct: 86 GAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDGEAEASRSLLTLDPPDHGALRGHF 145 Query: 130 IKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFG 189 I + L S+ + + ++ + + + F + + + Sbjct: 146 IPEFGLRRVRELRPSVEQIVTGLL-----DDLTARGDEADLLADFALPMATQVICRLL-- 198 Query: 190 RDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQK 249 D+ D + PA + ++ + Sbjct: 199 -DIPYEDRDYFQ-------ERTEQATRPAAGEEALEALLELRDYLDRLIS-------GKT 243 Query: 250 RESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMK 309 + + M + +++L A T S+ ++++P A + Sbjct: 244 GRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLLQHPTAWR 303 Query: 310 AATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKED 369 T NP L A + E LR S + +R Sbjct: 304 ELT-----------------VNPGLLPGA-----------VDELLRYLSIADGLRR---S 332 Query: 370 FTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLK 429 T +E + IR D + + D ++ +P F R Sbjct: 333 ATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHR------------------ 374 Query: 430 LKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGIL 489 ++ FG G C G+ A E++ L +L L A G+ Sbjct: 375 SARRHVAFGYGPHQCLGQNLARMELEVALGAVLERLPALRPTTDVAGLRLKSDSAVFGV- 433 Query: 490 PPLNDIEFKY 499 ++ + Sbjct: 434 ---YELPVAW 440 >5LIE-A nrPDB Length = 414 Score = 80.3 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 35/269 (13%), Positives = 78/269 (28%), Gaps = 51/269 (18%) Query: 197 TQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISEL 256 T + + ++ F A + L + + E + + + + + + Sbjct: 167 TDRHWLFEAVEPGFDFRGSRRATMPRLNVEDAGSRLYTYA--LELIAGKRAEPADDMLSV 224 Query: 257 ISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVK 316 ++ + D E ++ A T + L + NP+ ++ + + Sbjct: 225 VANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFE 284 Query: 317 RTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLED 376 +L + I+E +R +S S + R + Sbjct: 285 ----------------------------LLPTAIEEIVRWTSPSPSKRRTAS---RAVSL 313 Query: 377 GSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMP 436 G I + ++ + DP ++ F R ++ Sbjct: 314 GGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITR------------------KPNPHLG 355 Query: 437 FGSGATICPGRLFAIHEIKQFLILMLSYF 465 FG G C G A E++ +LS F Sbjct: 356 FGQGVHYCLGANLARLELRVLFEELLSRF 384 >5EX6-C nrPDB Length = 434 Score = 80.3 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 51/378 (13%), Positives = 95/378 (25%), Gaps = 79/378 (20%) Query: 117 MDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCY 176 D + + + + + + + + A + Sbjct: 127 YDPPEHTRLRRLLAPGFTHRKIRRMAPYIEQIVTERL-DEMEREGSPADLIELFADEVPG 185 Query: 177 RVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPAL-VAGLPIHMFRTAHNAR 235 V+ + G R +F L L + A Sbjct: 186 PVL-----CELLGVPRDDRA------------------MFLQLCHRHLDASLSGRRRAAA 222 Query: 236 EKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATF 295 + + + + M + + T D E + ++ A N Sbjct: 223 GEAFSRYLVTMVARERKDPGDGLIGMVVAEHGDTVTDEELRGVCVQMMLAGDDNISGMIG 282 Query: 296 WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLR 355 + ++RNPE + A D+P + + E +R Sbjct: 283 LGVLALLRNPEQIAALR----------------------------GDVPAAERAVDELIR 314 Query: 356 L--SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYL 413 + RTA ED T+ G I+ + + + DP + PD R Sbjct: 315 YLTVPYAPTPRTAIEDSTV----GDQVIKAGETVLCSLPTANRDPALLPDADRLDVTR-- 368 Query: 414 DENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF-ELELI-E 471 ++ FG G C G A E++ + F +L L Sbjct: 369 ----------------EAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADP 412 Query: 472 GQAKCPPLDQSRAGLGIL 489 A L G+ L Sbjct: 413 DGATEFRLSTPAYGISRL 430 >1GWI-A nrPDB Length = 411 Score = 79.9 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 66/462 (14%), Positives = 133/462 (28%), Gaps = 91/462 (19%) Query: 58 ANQRKHGHVFTCKL-MGKYVHFITNPLSYHKVLCHGKYFDWKKFH-----------FATS 105 A R G + +L G V +T+ +L + + Sbjct: 24 ARLRAAGPLAAVELPGGVPVWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPADWPLI 83 Query: 106 AKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAA 165 A RS+ +DG + + L + + + E R++ + ++ Sbjct: 84 GLANPGRSMLTVDGAEHRRLRTLVAQALTVRRVEHMRGRITELTDRLL-DELPADGGVVD 142 Query: 166 WVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPI 225 Y V+ + + G + R K ++V L Sbjct: 143 LKAAFAYPLPMYVVAD-----LMGIEEARLPRLKVLFEKFFSTQTPPEEVVATL------ 191 Query: 226 HMFRTAHNAREKLAESLRHENLQKRESI-SELISLRMFLNDTLSTFDDLEKAKTHLVVLW 284 +LA + KR + +L S + ++ D E T +++ Sbjct: 192 ----------TELASIMTDTVAAKRAAPGDDLTSALIQASENGDHLTDAEIVSTLQLMVA 241 Query: 285 ASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLP 344 A TI ++ + +P E + + + + S Sbjct: 242 AGHETTISLIVNAVVNLSTHP--------EQRALVLSGEAEWS----------------- 276 Query: 345 VLDSIIKESLRLSSAS--LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIY- 401 ++++E+LR S+ + + IR A ED + G I D + + + D + Sbjct: 277 ---AVVEETLRFSTPTSHVLIRFAAEDVPV----GDRVIPAGDALIVSYGALGRDERAHG 329 Query: 402 PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILM 461 P F R ++ FG G +CPG + E L + Sbjct: 330 PTADRFDLTR-----------------TSGNRHISFGHGPHVCPGAALSRMEAGVALPAL 372 Query: 462 LSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKH 503 + F P + + L ++ + H Sbjct: 373 YARF----PHLDLAVPAAELRNKPVVTQNDLFELPVRLAHHH 410 >1Z8P-A nrPDB Length = 404 Score = 79.9 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 59/423 (13%), Positives = 116/423 (27%), Gaps = 92/423 (21%) Query: 61 RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDP---- 116 R+ V + +G+ +T L + K + F P Sbjct: 24 RETAPVTPVRFLGQDAWLVTGYDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVR 83 Query: 117 ---------MDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWV 167 D T + + + ++ + + ++ S Sbjct: 84 NYFATNMGTSDPPTHTRLRKLVSQEFTVRRVEAMRPRVEQITAELLDEVGDSGVVDIVDR 143 Query: 168 TEGMYSF---CYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLP 224 C + + Y FGR + ++ P Sbjct: 144 FAHPLPIKVICELLGVDEKYRGEFGRWSSE------------------------ILVMDP 179 Query: 225 IHMFRTAHNAREKLAESLRHENLQKRESISELIS-LRMFLNDTLSTFDDLEKAKTHLVVL 283 + ARE + L ++ E +L+S L +D E LV+L Sbjct: 180 ERAEQRGQAAREVVNFILDLVERRRTEPGDDLLSALIRVQDDDDGRLSADELTSIALVLL 239 Query: 284 WASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDL 343 A +++ + ++ +P+ + + + L Sbjct: 240 LAGFESSVSLIGIGTYLLLTHPDQLALVR-------------------------RDPSAL 274 Query: 344 PVLDSIIKESLR-LSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYP 402 P + ++E LR ++ R A E+ + G I + + + + DP+ +P Sbjct: 275 P---NAVEEILRYIAPPETTTRFAAEEVEI----GGVAIPQYSTVLVANGAANRDPKQFP 327 Query: 403 DPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILML 462 DP F R ++ FG G C GR A E + L + Sbjct: 328 DPHRFDVTR------------------DTRGHLSFGQGIHFCMGRPLAKLEGEVALRALF 369 Query: 463 SYF 465 F Sbjct: 370 GRF 372 >5HIW-A nrPDB Length = 398 Score = 79.5 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 72/420 (17%), Positives = 121/420 (28%), Gaps = 77/420 (18%) Query: 50 ANPLEF---LRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSA 106 +P F L A R+H F L V + VL + F + + Sbjct: 13 KDPSAFGIHLAAAAREHSVYFDEGLG---VPVVLRGADVVAVLRDSETFSTRTYDTGIMK 69 Query: 107 KAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAW 166 A + G + F L ++ E+ + + R + + + Sbjct: 70 GAL-----VTLGGEAHTRMRRLFNAVLSPRVISRYEEATVTPVARRVVERLVRKERAE-- 122 Query: 167 VTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIH 226 ++ M +FG R A I + + + + Sbjct: 123 ----LFDDFAISMPMGVTSALFGLPEERIAENDALIRKMIRSVVMPQD-------PVVVA 171 Query: 227 MFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWAS 286 R+AH A E + + R + + L + E L ++ S Sbjct: 172 EGRSAHAAMEAQLREIAEREVAHPSDTLLGEIARAIVAEGLGGVEACE--GVVLTLILGS 229 Query: 287 QANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL 346 T L ++ +P+AM + +L Sbjct: 230 YETTSWMLANLLVALLAHPDAMNQLRQ----------------------------QPSLL 261 Query: 347 DSIIKESLRL-SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPL 405 I+ES R SSA+ +R + + T+ G + I+ L H D EIYP P Sbjct: 262 PQAIEESTRWCSSAAGIVRFVEREATI----GGETLAAGTILYLSLIARHYDEEIYPRPE 317 Query: 406 TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 TF R + FG G C G A E + + L+L F Sbjct: 318 TFDIHR------------------RPVGMLNFGGGLHYCVGAPLARMEARVGVSLLLERF 359 >5Z9I-A nrPDB Length = 398 Score = 79.1 bits (193), Expect = 4e-15, Method: Composition-based stats. Identities = 55/416 (13%), Positives = 113/416 (27%), Gaps = 62/416 (14%) Query: 78 FITNPLSYHKVLCHGKYF--DWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQG 135 P S +L + K F D + +A D + Sbjct: 38 VYGYPESA-AILSNPKVFSSDTMRLDPIKLDEAIVEGDFAHTDPPKHRRLRGLVDHAFTP 96 Query: 136 HALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRR 195 SL M + I+ + + + ++ ++ + G + R Sbjct: 97 ----SLVAKMESRVHGIIHELLDGVEGKSQFDLVAEFAAPLPLIM---ISDLLGVPESDR 149 Query: 196 DTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISE 255 + + LD ++F+ P V + + E ++ + Sbjct: 150 ALFRQWMDKMLDGSEKFES--PETVLEQEEELHKELELLWEMRDYWHERAAESRKRPRED 207 Query: 256 LISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEV 315 LIS + +D + + +L T ++ + + Sbjct: 208 LISQLVHAEVDGQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCLDAFSDQDARVR--- 264 Query: 316 KRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLE 375 A+ + +P ++++ES+R S + A +E Sbjct: 265 ----------------------ADRSLVP---ALLEESMRYMSPICGVGRATNS---EVE 296 Query: 376 DGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYM 435 I KD ++ ++ + D + P F R ++ Sbjct: 297 VAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGR------------------SPNAHL 338 Query: 436 PFGSGATICPGRLFAIHEIKQFLILMLSYF-ELELIEGQAKCPPLDQSRAGLGILP 490 FG G C GR A E K + ++L L +G+ LP Sbjct: 339 GFGRGIHFCLGRQLARMESKAAVEILLDRLPTLRADPANPPTFLQVVDASGVATLP 394 >4TRI-A nrPDB Length = 407 Score = 78.8 bits (192), Expect = 5e-15, Method: Composition-based stats. Identities = 46/275 (16%), Positives = 79/275 (28%), Gaps = 60/275 (21%) Query: 213 DKVFPALVAGLPIHMFRTAHNA-REKLAESLR------HENLQKRES--ISELISLRMFL 263 + L + A +KL ++ + + KR + +L S+ + Sbjct: 152 RDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNS 211 Query: 264 NDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAG 323 D E L++L T Q++R+ + A +V Sbjct: 212 EVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVD------- 264 Query: 324 QKVSLEGNPICLSQAELNDLPVLDSIIKESLRL-SSASLNIRTAKEDFTLHLEDGSYNIR 382 +L I+E LR S RT D H +R Sbjct: 265 ---------------------LLPGAIEEMLRWTSPVKNMCRTLTADTVFH----GTELR 299 Query: 383 KDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGAT 442 + I L + + D ++ DP F+ DR ++ FG G Sbjct: 300 AGEKIMLMFESANFDESVFGDPDNFRIDR------------------NPNSHVAFGFGTH 341 Query: 443 ICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCP 477 C G A E++ +L + A P Sbjct: 342 FCLGNQLARLELRLMTERVLRRLPDLRLADDAPVP 376 >3AWQ-A nrPDB Length = 415 Score = 78.8 bits (192), Expect = 5e-15, Method: Composition-based stats. Identities = 53/447 (11%), Positives = 117/447 (26%), Gaps = 79/447 (17%) Query: 44 CALQFGANPLEFLRANQRKHG-HVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHF 102 L A+P F+ ++ G + F + + K + + + ++ Sbjct: 12 ETLSLLADPYRFISRQCQRLGANAFESRFLLKKTNCLKGAKAAEIFYDTTRFEREGAMPV 71 Query: 103 ATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSK 162 A FG + +DG T + F+ + + +L + +R + Sbjct: 72 AIQKTLFGQGGVQGLDGETHRHRKQMFMGLMTPERVRALAQLFEAEWRRAVP-------- 123 Query: 163 TAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAG 222 W +G +F +L T+ G Sbjct: 124 --GWTRKGEI--------------VFYDELHEPLTRAVCAWA-----------------G 150 Query: 223 LPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVV 282 +P+ A + E + S L S +E + Sbjct: 151 VPLPD----DEAGNRAGELRALFDAAGSASPRHLWSRLARRRVDAWAKRIIEGIRA--GS 204 Query: 283 LWASQANTIPATFWSLFQMIRN-----PEAMKAATEEVKRTLENAGQKVSLEGNPIC--- 334 + + A W R+ P V R ++ + + Sbjct: 205 IGSGSGTAAYAIAW---HRDRHDDLLSPHVAAVELVNVLRPTVAIAVYITFVAHALQTCS 261 Query: 335 -LSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQL 393 + A + + ++E R + E + + L Sbjct: 262 GIRAALVQQPDYAELFVQEVRRFYP---FFPAVVARASQDFEWEGMAFPEGRQVVLDLYG 318 Query: 394 MHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGA----TICPGRLF 449 + D + DP F+ +R+ + + ++P G G CPG Sbjct: 319 SNHDAATWADPQEFRPERF------------RAWDEDSFNFIPQGGGDHYLGHRCPGEWI 366 Query: 450 AIHEIKQFLILMLSYFELELIEGQAKC 476 + +K L+++ ++ + Sbjct: 367 VLAIMKVAAHLLVNAMRYDVPDQDLSI 393 >1F4U-A nrPDB Length = 368 Score = 78.8 bits (192), Expect = 6e-15, Method: Composition-based stats. Identities = 38/241 (15%), Positives = 70/241 (29%), Gaps = 53/241 (21%) Query: 237 KLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFW 296 +L + ++ ++ + S D+EK +++L A T Sbjct: 163 ELGKKYLELIGYVKDHLNS--GTEVVSRVVNSNLSDIEKLGYIILLLIAGNETTTNLISN 220 Query: 297 SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL 356 S+ R + EE L + I+E+LR Sbjct: 221 SVIDFTRF-NLWQRIREENL----------------------------YLKA-IEEALRY 250 Query: 357 SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDEN 416 S + ++ G I + + + ++ + D E++ D F DR Sbjct: 251 SPPVM---RTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIPDR----- 302 Query: 417 GKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKC 476 ++ FGSG +C G A E + + F I K Sbjct: 303 -------------NPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFRHIEILDTEKV 349 Query: 477 P 477 P Sbjct: 350 P 350 >6A7J-A nrPDB Length = 411 Score = 78.8 bits (192), Expect = 6e-15, Method: Composition-based stats. Identities = 67/455 (14%), Positives = 126/455 (27%), Gaps = 86/455 (18%) Query: 58 ANQRKHGHVFTCKL-MGKYVHFITNPLSYHKVLCHGKYFDWKKFH-----------FATS 105 A R G + +L G +V+ +T+ +L + + Sbjct: 20 AALRAAGPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKDINVWNAWQRGEIPADWPLI 79 Query: 106 AKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAA 165 RS+ +DG + + L + L + + + + Sbjct: 80 GLVNPGRSMLTVDGPDHRRLRTLVAQALTVKRVEKLRAGIEALTNASLERLAALPAGEPV 139 Query: 166 W-VTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLP 224 E Y V+ E + G D K ++V P ++A L Sbjct: 140 DLKAEFAYPLPMNVISE-----LMGVDAADHPRLKELFEKFFSTQTPPEEV-PQMMADL- 192 Query: 225 IHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLW 284 K+ E + +L S + ++ D E T +++ Sbjct: 193 -------GTLFTKIVEEKKANPG------DDLTSALIAASEDGDHLTDEEILNTLQLIIA 239 Query: 285 ASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLP 344 A TI + + +PE K ++P Sbjct: 240 AGHETTISLIVNVVEALAIHPEQRKKVLS---------------------------GEIP 272 Query: 345 VLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIY-PD 403 + +I+E+LR ++ T +E G + K + + + + D E Y P Sbjct: 273 W-EGVIEETLRWNTP--TSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPT 329 Query: 404 PLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLS 463 F R ++ FG G +CPG + E L + Sbjct: 330 AGDFDATR------------------TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYE 371 Query: 464 YFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFK 498 F E P + + L+D+ K Sbjct: 372 RF----PELDLAVPAAELRNKPIVTQNDLHDLPVK 402 >3P3Z-A nrPDB Length = 416 Score = 78.8 bits (192), Expect = 6e-15, Method: Composition-based stats. Identities = 32/239 (13%), Positives = 67/239 (28%), Gaps = 47/239 (19%) Query: 237 KLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFW 296 ++ + L +++ + ++ + DD E VL A T Sbjct: 205 RMFDYLVAAIEKRKVEPGDDLTSDIVRAFHDGVLDDYELRTLVATVLVAGYETTNHQLAL 264 Query: 297 SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL 356 +++ ++P+ E + + ++E LR Sbjct: 265 AMYDFAQHPDQWMKIKE----------------------------NPELAPQAVEEVLRW 296 Query: 357 SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDEN 416 S A E I + + + H DP ++ D F Sbjct: 297 SPTLPVT--ATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDIT------ 348 Query: 417 GKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAK 475 +K + + FG G C G A E+ + + + + + I G+ Sbjct: 349 -----------VKREAPSIAFGGGPHFCLGTALARLELTEAVAALATRLDPPQIAGEIT 396 >1UE8-A nrPDB Length = 367 Score = 77.6 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 35/210 (16%), Positives = 72/210 (34%), Gaps = 52/210 (24%) Query: 267 LSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKV 326 S +LEK ++++ A T +I N Sbjct: 192 NSNLSELEKEGYFILLMIAGNETTT--------NLIGN---------------------- 221 Query: 327 SLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDI 386 ++E + S + + L ++ +E+LR S + ++ ++ I + ++ Sbjct: 222 AIEDFTLYNSWDYVREKGALKAV-EEALRFSPPVMRTIRVTKE---KVKIRDQVIDEGEL 277 Query: 387 IALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPG 446 + ++ + D E++ DP +F DR ++ FGSG +C G Sbjct: 278 VRVWIASANRDEEVFKDPDSFIPDR------------------TPNPHLSFGSGIHLCLG 319 Query: 447 RLFAIHEIKQFLILMLSYFELELIEGQAKC 476 A E + L F ++ I + K Sbjct: 320 APLARLEARIALEEFAKKFRVKEIVKKEKI 349 >6A7I-A nrPDB Length = 411 Score = 77.6 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 68/455 (14%), Positives = 127/455 (27%), Gaps = 86/455 (18%) Query: 58 ANQRKHGHVFTCKL-MGKYVHFITNPLSYHKVLCHGKYFDWKKFH-----------FATS 105 A R G + +L G +V+ +T +L + + Sbjct: 20 AALRAAGPLAEVELPGGVHVYAVTRHAEARALLTDSRVVKDIDVWNAWRRGEIPMDWPLI 79 Query: 106 AKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAA 165 A RS+ +DG + + L + L + + + + Sbjct: 80 GLANPGRSMLTVDGADHRRLRTLVAQALTVKRVERLRAGIEALTNASLEKLAALPAGEPV 139 Query: 166 W-VTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLP 224 E Y V+ E + G D K ++V P ++A L Sbjct: 140 DLKAEFAYPLPMNVISE-----LMGVDAADHPRLKELFEKFFSTQTPPEEV-PQMMADL- 192 Query: 225 IHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLW 284 K+ ++ R +L S + ++ D E T +++ Sbjct: 193 -------GALFTKIVDAKRTNPG------DDLTSALIAASENGDHLTDEEIVNTLQLIIA 239 Query: 285 ASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLP 344 A TI + + +PE K ++ +G Sbjct: 240 AGHETTISLIVNVVEALQTHPEQRKKV----------LNGEIGWDG-------------- 275 Query: 345 VLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIY-PD 403 +I+E+LR ++ T +E G + K + + + + D E Y P Sbjct: 276 ----VIEETLRWNTP--TSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQYGPT 329 Query: 404 PLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLS 463 F R ++ FG G +CPG + E L + Sbjct: 330 AGEFDATR------------------TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYE 371 Query: 464 YFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFK 498 F E P D + L+++ K Sbjct: 372 RF----PELDLAVPASDLRNKPIVTQNDLHELPVK 402 >6G5O-A nrPDB Length = 399 Score = 76.8 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 49/388 (12%), Positives = 108/388 (27%), Gaps = 85/388 (21%) Query: 115 DPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSF 174 P+ G + F + LQ LT + E ++ + E + F Sbjct: 77 PPVHGVYRAIVEPWFKRPLQAEYQEKLTAQISEIVEETLL----------KGSVEVVTDF 126 Query: 175 CYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNA 234 R+ A L + +T + + A Sbjct: 127 ALRLQSRALTLLL--------NTPFSESETWIS---------WGTHVFRSEGEALDGDKA 169 Query: 235 REKLAESLRHENLQKRESI--SELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIP 292 + E + + ++ S+ + E ++ + I Sbjct: 170 N--ILYHYIDEQIDRASENPGDDMYSVLLNSEFEGRKLTKEEVKGVMVLTFAGGRDTVIN 227 Query: 293 ATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKE 352 A S+ + +PEA++ +E + + ++E Sbjct: 228 AVTNSIAYLAEHPEALERLRKEPE----------------------------ITGRAVEE 259 Query: 353 SLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRY 412 +R S + T + ++ D I+L + D ++ +P DR Sbjct: 260 MIRYFSPLTQMGRV---VTEDTHVCEHAVKADSRISLCWASANRDAAVFENPNEIVLDRK 316 Query: 413 LDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF-ELELIE 471 ++ ++ FG C G A +K L + E+++ Sbjct: 317 VNP------------------HVGFGFSHHNCLGATHARQILKILLQTLAQKVASFEILD 358 Query: 472 GQAKCPPLDQSRAGLGILPPLNDIEFKY 499 + LD + +G ++I+ K+ Sbjct: 359 YKENIEDLDHFQRKVGF----HNIQIKF 382 >5M0P-A nrPDB Length = 428 Score = 76.8 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 56/424 (13%), Positives = 112/424 (26%), Gaps = 74/424 (17%) Query: 66 VFTCK-LMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTEN 124 VF K L GK +T + G +I +DG Sbjct: 41 VFQTKALGGKPFVVVTGKEGAEMFYNNDVVQREGMLPKRIVNTLAGKGAIHTVDGKKH-V 99 Query: 125 INDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGY 184 +L + + L ++ + + +Y ++ + G Sbjct: 100 DRKALFMSLMTEGNLNYVRELTRTL------WHANTQRMESMDEVNIYRESIVLLTKVGT 153 Query: 185 LTIFGRDLTRRDTQKAHILNNL--DNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESL 242 G D ++ ++ D+F+ F ++ + AR ++ + L Sbjct: 154 R-WAGVQAPPEDIERIATDMDIMIDSFRALGGAFKG---------YKASKEARRRVEDWL 203 Query: 243 RHENLQKRE---SISELISLRMFL--NDTLSTFDDLEKAKTHLVVLWASQANTIPATFWS 297 + ++ R+ E +L F D L D L+ + + Sbjct: 204 EEQIIETRKGNIHPPEGTALYEFAHWEDYLGNPMDSRTCAIDLMNTFRPLIAINRFVSFG 263 Query: 298 LFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLS 357 L M NP + E +E R Sbjct: 264 LHAMNENPITREKIKSEPD----------------------------YAYKFAQEVRRYY 295 Query: 358 S-ASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDEN 416 AK D ++ I +AL D ++ DP F+ +R+ + Sbjct: 296 PFVPFLPGKAKVD----IDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFETWD 351 Query: 417 GKTKTTFYCNGLKLKYYYMPFGSGA----TICPGRLFAIHEIKQFLILMLSYFELELIEG 472 G + +P G G C G + +++ + ++ E Sbjct: 352 GS------------PFDLIPQGGGDYWTNHRCAGEWITVIIMEETMKYFAEKITYDVPEQ 399 Query: 473 QAKC 476 + Sbjct: 400 DLEV 403 >5FYF-A nrPDB Length = 470 Score = 76.8 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 38/239 (15%), Positives = 73/239 (30%), Gaps = 51/239 (21%) Query: 230 TAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFD-DLEKAKTHLVVLWASQA 288 + +L E +LISL +T + +E +++ Sbjct: 251 DMARSFSRLWRDKEARRAAGEEPGFDLISLLQSNKETKDLINRPMEFIGNLTLLIVGGND 310 Query: 289 NTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDS 348 T + L M P + + + ++ + Sbjct: 311 TTRNSMSGGLVAMNEFPREFEKLKAKPE----------------------------LIPN 342 Query: 349 IIKESLRL-SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTF 407 ++ E +R + + R AK+D L G I+K D + ++ + D + +P F Sbjct: 343 MVSEIIRWQTPLAYMRRIAKQDVEL----GGQTIKKGDRVVMWYASGNRDERKFDNPDQF 398 Query: 408 KYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFE 466 DR K +M FG G C G A +++ +L F+ Sbjct: 399 IIDR-----------------KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFD 440 >1UED-A nrPDB Length = 406 Score = 76.4 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 57/426 (13%), Positives = 118/426 (27%), Gaps = 71/426 (16%) Query: 50 ANPLEF-LRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKA 108 P F LR N H F + G V + + G+ F W+ + + Sbjct: 13 REPANFQLRTNCDPHEDNFGLRAHGPLVRIVGESSTQL-----GRDFVWQAHGYEVVRRI 67 Query: 109 FGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSN-----SKT 163 G T++ + ++ +++ L++++ P + Sbjct: 68 LGDHEHFTTRPQFTQSKSGAHVEAQFVGQISTYDPPEHTRLRKMLTPEFTVRRIRRMEPA 127 Query: 164 AAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFD--KVFPALVA 221 + + A +F + AH L L + D + + Sbjct: 128 IQSLIDDRLDLLEAEGPSADLQGLFADPVG------AHALCELLGIPRDDQREFVRRIRR 181 Query: 222 GLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLV 281 + A A L ++ + + L M + D D E Sbjct: 182 NADLSRGLKARAADSAAFNRYLDNLLARQRADPDDGLLGMIVRDHGDNVTDEELKGLCTA 241 Query: 282 VLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELN 341 ++ + + ++ NP ++ E ++ Sbjct: 242 LILGGVETVAGMIGFGVLALLDNPGQIELLFESPEKA----------------------- 278 Query: 342 DLPVLDSIIKESLRLSSA--SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPE 399 + ++ E +R S + N R A +D + + I+ D + + + D Sbjct: 279 -----ERVVNELVRYLSPVQAPNPRLAIKDVVIDGQ----LIKAGDYVLCSILMANRDEA 329 Query: 400 IYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLI 459 + PDP LD N + + FG G C G A ++ Sbjct: 330 LTPDPDV------LDANRAAVSD------------VGFGHGIHYCVGAALARSMLRMAYQ 371 Query: 460 LMLSYF 465 + F Sbjct: 372 TLWRRF 377 >4OQR-A nrPDB Length = 457 Score = 76.1 bits (185), Expect = 4e-14, Method: Composition-based stats. Identities = 48/263 (18%), Positives = 89/263 (33%), Gaps = 56/263 (21%) Query: 234 AREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPA 293 A KL + KR S + + + + + D E L++L A T Sbjct: 231 ALGKLTRYIAELVATKRLSPKDDLLGSLITD---TDLTDEELTNIALILLVAGHETTANM 287 Query: 294 TFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKES 353 F ++++PE ++ +L D++ +E Sbjct: 288 LGLGTFALLQHPE--------------------------------QIANLDSPDAV-EEL 314 Query: 354 LRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYL 413 LR S +++ T +E IRK D +A+ ++ DP+++ +P + DR Sbjct: 315 LRYLSI-VHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR-- 371 Query: 414 DENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF-ELELIEG 472 + FG G C G+ A E++ + + F L L Sbjct: 372 ---------------VDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVP 416 Query: 473 QAKCPPLDQS-RAGLGILPPLND 494 + ++S G+ LP D Sbjct: 417 AEEIKLREKSAAYGVWALPVAWD 439 >1LG9-A nrPDB Length = 398 Score = 76.1 bits (185), Expect = 4e-14, Method: Composition-based stats. Identities = 46/352 (13%), Positives = 88/352 (25%), Gaps = 77/352 (21%) Query: 117 MDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCY 176 D + + + + + + + + S + +F Sbjct: 91 YDPPEHTRLRRKLTPGFTLRKMQRMAPYIEQIVNDRLDEMERAGSPA------DLIAFVA 144 Query: 177 RVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPAL-VAGLPIHMFRTAHNAR 235 + A + G RD +F L L + + A Sbjct: 145 DKVPGAVLCELVGVPRDDRD------------------MFMKLCHGHLDASLSQKRRAAL 186 Query: 236 EKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATF 295 + + + + + D E + V+ A N Sbjct: 187 GDKFSRYLLAMIARERKEPGEGMIGAVVAEYGDDATDEELRGFCVQVMLAGDDNISGMIG 246 Query: 296 WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLR 355 + M+R+PE + A + + + E +R Sbjct: 247 LGVLAMLRHPEQIDAFRGDEQSA----------------------------QRAVDELIR 278 Query: 356 L--SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYL 413 S R A+ED TL ++ I+K D + + DP + PD R Sbjct: 279 YLTVPYSPTPRIAREDLTLAGQE----IKKGDSVICSLPAANRDPALAPDVDRLDVTR-- 332 Query: 414 DENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 ++ FG G C G A E++ + F Sbjct: 333 ----------------EPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRF 368 >6HQD-A nrPDB Length = 420 Score = 75.7 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 59/418 (14%), Positives = 117/418 (27%), Gaps = 69/418 (16%) Query: 62 KHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNT 121 ++G ++ V TN + +G + A + + MD Sbjct: 54 EYGPYWSITKFSDIVAIDTNHKVFSSDHTNGSFVLDDTTLNAVDGGIYLPNFLG-MDPPK 112 Query: 122 TENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFE 181 + + L ++ E +R++ WV ++ Sbjct: 113 HDVHRMVVSPIVAPQNLLRFEATIRERTKRVLSELPIGEEF--NWVDRVSIELTTMML-- 168 Query: 182 AGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAES 241 T+ D D +K +++ + + + ++L Sbjct: 169 ---ATLL--DFPFDDRRKLTRWSDIITTRPGYGLVDSWEQR--ESELMECLAYFQRLYAE 221 Query: 242 LRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQM 301 K + IS L + + + T +++ T + S Sbjct: 222 R-QAMPPKPDLISML-----AHSPEMQDLTPTDFLGTLALLIVGGNDTTRSSMSGSAMAC 275 Query: 302 IRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL-SSAS 360 P +E + N +L S+I E +R + + Sbjct: 276 HLYP-------QEFDKVRNNRA---------------------LLASVIPEVVRWQTPIA 307 Query: 361 LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK 420 RTA ED E IRK D + ++ + D E+ P+ F DR Sbjct: 308 HMRRTALEDV----EFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDFIADR--------- 354 Query: 421 TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF-ELELIEGQAKCP 477 +++ FG G C G A ++K M + +E+ + P Sbjct: 355 --------PRARHHLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPVRVP 404 >2XKR-A nrPDB Length = 398 Score = 75.7 bits (184), Expect = 5e-14, Method: Composition-based stats. Identities = 44/292 (15%), Positives = 84/292 (28%), Gaps = 61/292 (20%) Query: 213 DKVFPALVAGLPIHMFRTAHNAREKLAE-SLRHENLQKRESISELISLRMFLNDTLSTFD 271 D + L + + F+ +A + + ++ + +L+S+ + Sbjct: 157 DDLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLVSSEVDGERLS 216 Query: 272 DLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGN 331 D E L++L T Q++RN + Sbjct: 217 DDELVMETLLILIGGDETTRHTLSGGTEQLLRNRD------------------------- 251 Query: 332 PICLSQAELNDLP-VLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALY 390 L P +L I+E LR ++ N+ T E + + + L Sbjct: 252 ----QWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRV---LTADTEFHGTALCAGEKMMLL 304 Query: 391 PQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA 450 + + D ++ +P F R ++ FG G C G A Sbjct: 305 FESANFDEAVFCEPEKFDVQR------------------NPNSHLAFGFGTHFCLGNQLA 346 Query: 451 IHEIKQFLILMLSYF-ELELIEGQAKCPP--------LDQSRAGLGILPPLN 493 E+ +L +L L+ + P L+ PPL Sbjct: 347 RLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPPLG 398 >5L1U-A nrPDB Length = 401 Score = 75.7 bits (184), Expect = 5e-14, Method: Composition-based stats. Identities = 59/417 (14%), Positives = 111/417 (26%), Gaps = 85/417 (20%) Query: 61 RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGN 120 +K G + G+ +T +L + ++ A + G+ Sbjct: 28 QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALAAGD 87 Query: 121 TTENI-------NDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYS 173 E I L + + ++ ++ +++++ + Sbjct: 88 DHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQ-LAASAPPVDLHRVLSFR 146 Query: 174 FCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHN 233 V+ + G L R + + N Sbjct: 147 LPTMVV-----CDLLGVPLADR-ERFGQ----------------WARGTFDQSDNEHSAN 184 Query: 234 AREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPA 293 +++ + + +KR + I L + + D + A VL TI Sbjct: 185 TFQQVVDYMLELVARKRVEPGDDI-LSELIAEKDGALSDADIAHLGNAVLLFGYETTIVR 243 Query: 294 TFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKES 353 ++RNP +A E + + ++E Sbjct: 244 IDLGTLLLLRNP-VQRAQLAEDPG---------------------------LAPAAVEEI 275 Query: 354 LRLS-----SASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFK 408 LRL S +L R A D T+ G IR D + L + D +PD F Sbjct: 276 LRLGVGGKGSNALIPRYAHGDITV----GETVIRTGDAVMLAIGAANYDDRAFPDGGLFD 331 Query: 409 YDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 R ++ FG GA C GR A E+ + Sbjct: 332 LTR-----------------VRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRL 371 >3MGX-A nrPDB Length = 415 Score = 75.3 bits (183), Expect = 5e-14, Method: Composition-based stats. Identities = 37/274 (13%), Positives = 80/274 (29%), Gaps = 61/274 (22%) Query: 230 TAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQAN 289 T A ++ +R+ + + + +D L+ DD+ ++ L Sbjct: 202 TPRQAHTEILVYFDELITARRKEPGDDLVSTLVTDDDLT-IDDVLLNCDNV--LIGGNET 258 Query: 290 TIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSI 349 T A ++ + P + A + D++ Sbjct: 259 TRHAITGAVHALATVPGLLTALRDGSADV----------------------------DTV 290 Query: 350 IKESLRL-SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFK 408 ++E LR S A +R D T++ D + + + + DP + DP TF Sbjct: 291 VEEVLRWTSPAMHVLRVTTADVTINGRD----LPSGTPVVAWLPAANRDPAEFDDPDTFL 346 Query: 409 YDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELE 468 R ++ FG G C G A E+ L ++ Sbjct: 347 PGR------------------KPNRHITFGHGMHHCLGSALARIELSVVLRVLAERVS-- 386 Query: 469 LIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFK 502 + + ++ ++ ++ + Sbjct: 387 -----RVDLEREPAWLRAIVVQGYRELPVRFTGR 415 >3WVS-A nrPDB Length = 401 Score = 75.3 bits (183), Expect = 6e-14, Method: Composition-based stats. Identities = 53/352 (15%), Positives = 100/352 (28%), Gaps = 73/352 (20%) Query: 117 MDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCY 176 MD + K + L + +L + + + + A V + Sbjct: 93 MDAPDHTRLRRLISKAFTIRRVEELRPKV-HDLAHRLIDDMLAKGEPADLVADYALPIPT 151 Query: 177 RVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNARE 236 V+ E + R+ R T + L+ P Sbjct: 152 TVICELLGVPFEDREKFGRWTDAILSTSTLN----------------PEEGRVKRMELVG 195 Query: 237 KLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFW 296 + + Q + +LIS + D + E + +L A T Sbjct: 196 YIGGIIAARRAQPAD---DLISGMIEARDVQDKLTEQELLDHCIGLLIAGHETTASQIPS 252 Query: 297 SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL 356 ++ ++ P+ K L+D ++ S ++E R Sbjct: 253 FVYALLDQPQHWKRL----------------------------LDDPELIPSAVEELFRF 284 Query: 357 SSA---SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYL 413 S R A+ED +E G +R + + + + D + DP K DR Sbjct: 285 VPLGSGSAAPRYARED----IEVGGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDR-- 338 Query: 414 DENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 +++ FG G C G A E+++ L +L Sbjct: 339 ----------------PSNHHIGFGHGIHHCLGAPLARLELQEALRALLERL 374 >4OQS-A nrPDB Length = 433 Score = 74.9 bits (182), Expect = 7e-14, Method: Composition-based stats. Identities = 49/265 (18%), Positives = 88/265 (33%), Gaps = 56/265 (21%) Query: 234 AREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPA 293 A KL + KR S + + + + + D E L++L A T Sbjct: 192 ALGKLTRYIAELVATKRLSPKDDLLGSLITD---TDLTDEELTNIALLLLVAGHETTANM 248 Query: 294 TFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKES 353 F ++++PE + A L D++ +E Sbjct: 249 LGLGTFALLQHPEQIAA--------------------------------LDSPDAV-EEL 275 Query: 354 LRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYL 413 LR S +++ T +E IRK D +A+ ++ DP+++ +P + DR Sbjct: 276 LRYLSI-VHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR-- 332 Query: 414 DENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF-ELELIEG 472 + FG G C G+ A E++ + + F L L Sbjct: 333 ---------------VDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVP 377 Query: 473 QAKCPPLDQS-RAGLGILPPLNDIE 496 + ++S G+ LP D Sbjct: 378 AEEIKLREKSAAYGVWALPVAWDAR 402 >3TKT-A nrPDB Length = 450 Score = 74.5 bits (181), Expect = 9e-14, Method: Composition-based stats. Identities = 41/254 (16%), Positives = 85/254 (33%), Gaps = 52/254 (20%) Query: 224 PIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDT-LSTFDDLEKAKTHLVV 282 P + + A + ++R + ++ ++ + D + A +++ Sbjct: 227 PEQISQIVAGAVAEFERYFAGLAAERRRNPTDDVATVIANAVVDGEPMSDRDTAGYYIIT 286 Query: 283 LWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELND 342 A T ++ + + R+P+ A+ N Sbjct: 287 ASAGHDTTSASSAGAALALARDPDLFARVK-------------------------ADRNL 321 Query: 343 LPVLDSIIKESLRLS-SASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIY 401 LP I++E++R + +RTA D L + I D + L + DP + Sbjct: 322 LP---GIVEEAIRWTTPVQHFMRTAATDTELCGQK----IAAGDWLMLNYVAANHDPAQF 374 Query: 402 PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILM 461 P+P F R ++ FG+G+ C G A E++ L ++ Sbjct: 375 PEPRKFDPTR------------------PANRHLAFGAGSHQCLGLHLARLEMRVLLDVL 416 Query: 462 LSYFELELIEGQAK 475 L + + G+ K Sbjct: 417 LDRVDSLELAGEPK 430 >2WIY-A nrPDB Length = 394 Score = 74.5 bits (181), Expect = 9e-14, Method: Composition-based stats. Identities = 41/255 (16%), Positives = 70/255 (27%), Gaps = 49/255 (19%) Query: 230 TAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQAN 289 A A L+ + KR + + ++ + + E T LV Sbjct: 178 RAAVAFGYLSARVAEMLEDKRVNPGDGLADSLLDAARAGEITESEAIATILVFYAVGHMA 237 Query: 290 TIPATFWSLFQMIRNPEAMKAAT-EEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDS 348 + R PE A +E R + Sbjct: 238 IGYLIASGIELFARRPEVFTAFRNDESARA-----------------------------A 268 Query: 349 IIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFK 408 II E +R+ L+ T +E G I I + DPE++ DP F Sbjct: 269 IINEMVRMDPPQLSFLRFP---TEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFD 325 Query: 409 YDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELE 468 + R + FG G C G++ + E ++ +E Sbjct: 326 HTR----------------PPAASRNLSFGLGPHSCAGQIISRAEATTVFAVLAERYERI 369 Query: 469 LIEGQAKCPPLDQSR 483 + + D +R Sbjct: 370 ELAEEPTVAHNDFAR 384 >4YZR-A nrPDB Length = 405 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 37/241 (15%), Positives = 79/241 (32%), Gaps = 54/241 (22%) Query: 233 NAREKLAESLRHENLQKR-ESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTI 291 A + + + +R + +LIS + + S + E +++ A T+ Sbjct: 188 QALREFKDYIAKLIHDRRIKPKDDLISKLVHAEENGSKLSEKELYSMLFLLVVAGLETTV 247 Query: 292 PATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIK 351 ++++ + + ++ + ++ Sbjct: 248 NLLGSGTLALLQHKKECEKLKQQPEMIATA----------------------------VE 279 Query: 352 ESLRLSSASLNI--RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKY 409 E LR +S + + R A EDFT ++I++ D+I + + DP + +P Sbjct: 280 ELLRYTSPVVMMANRWAIEDFTYK----GHSIKRGDMIFIGIGSANRDPNFFENPEILNI 335 Query: 410 DRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF-ELE 468 +R ++ FG G C G A E +L F ++E Sbjct: 336 NR------------------SPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIE 377 Query: 469 L 469 L Sbjct: 378 L 378 >3A50-A nrPDB Length = 411 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 59/386 (15%), Positives = 103/386 (26%), Gaps = 87/386 (22%) Query: 87 KVLCHGKYFDWK---KFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTE 143 + DW+ A + MD + ++ +N L Sbjct: 57 AFVDPRLSKDWRHRLPEDQRADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEP 116 Query: 144 SMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEA---GYLTIFGRDLTRRDTQKA 200 + E ++ A T+G F+ + G RD A Sbjct: 117 RITEIADGLL----------AGLPTDGPVDLMREYAFQIPVQVICELLGLPAEDRDDFSA 166 Query: 201 HILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISE--LIS 258 +D+ DK + A KL L +KR + L S Sbjct: 167 WSSVLVDDSPADDK-----------------NAAMGKLHGYLSDLLERKRTEPDDALLSS 209 Query: 259 LRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRT 318 L + E +++L A T+ + ++ +P+ + E Sbjct: 210 LLAVSDMDGDRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPD-QRKLLAEDPSL 268 Query: 319 LENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS--LNIRTAKEDFTLHLED 376 + +A ++E LR S IR ED T Sbjct: 269 ISSA---------------------------VEEFLRFDSPVSQAPIRFTAEDVTYS--- 298 Query: 377 GSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMP 436 I +++ L + D + P+P R D +G + Sbjct: 299 -GVTIPAGEMVMLGLAAANRDADWMPEPDRLDITR--DASGG----------------VF 339 Query: 437 FGSGATICPGRLFAIHEIKQFLILML 462 FG G C G A E + + + Sbjct: 340 FGHGIHFCLGAQLARLEGRVAIGRLF 365 >4Z5P-A nrPDB Length = 400 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 54/377 (14%), Positives = 107/377 (28%), Gaps = 74/377 (19%) Query: 112 RSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGM 171 +I +D + K + ++ +S +E L + V A V + Sbjct: 84 DTILSLDPPEHTRLRRLLSKAFTARRMGAM-QSWLEELFAGLLDGVERTGHPADIVRDLA 142 Query: 172 YSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTA 231 F V+ + G R F+ + +V + A A Sbjct: 143 QPFTIAVI-----CRLLGVPYEDRGR-----------FQHWSEVIMSTTAY----SKEEA 182 Query: 232 HNAREKLAESLRHENLQKRESI-SELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANT 290 +A + L +R + +L+ + + D + E + +L A + Sbjct: 183 VSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDDDRLTEDELITFGVTLLVAGHETS 242 Query: 291 IPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSII 350 ++ ++ + + + E+ + +L + Sbjct: 243 AHQLGNMVYALLTHEDQLSLLREQPE----------------------------LLPRAV 274 Query: 351 KESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYD 410 +E LR + A+ G +R + + + DP + DP Sbjct: 275 EELLRFVPLGNGVGNARIALEDVELSGG-TVRAGEGVVAAAVNANRDPRAFDDPDRLDIT 333 Query: 411 RYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELI 470 R K ++ FG GA C G A E++ + +L F Sbjct: 334 R------------------EKNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERF----- 370 Query: 471 EGQAKCPPLDQSRAGLG 487 G P DQ G Sbjct: 371 PGLRLAVPADQVEWKTG 387 >5XW2-A nrPDB Length = 419 Score = 73.0 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 58/447 (12%), Positives = 125/447 (27%), Gaps = 73/447 (16%) Query: 44 CALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFA 103 +G P + + +++ + + + + + +P ++ + + Sbjct: 34 HFWLYGRRPRQMVEFDEKM--NAWNVYGYAEAIEVLGDPGTFSSHMS--------RLLPM 83 Query: 104 TSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKT 163 + +AF + D + + L + Q ++ ++ Sbjct: 84 GADEAFTEGDLLQTDPPDHRELRKLVSHAFTPKVVAELEPRITALTQELLDAVADRDTFD 143 Query: 164 AAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGL 223 ++ V A L+I D + I+++L V Sbjct: 144 L----MTALAYPLPVTVVAELLSIPSADRHLFEGWMTEIVHSL------GDVSMEDAPED 193 Query: 224 PIHMFRTAHNAREKLAESLRHENLQ-KRESISELISLRMFLNDTLSTFDDLEKAKTHLVV 282 +F K+ E LR + +R +L+ + D ++ Sbjct: 194 QERIFEAGMAPMRKMLEYLREHAAECRRRPRGDLMGKLIEAEVDGRRLTDNHIVNFAKML 253 Query: 283 LWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELND 342 L A T ++ + PE A+ + Sbjct: 254 LIAGYLTTTMLIGNTVLCLDSYPEQAARVR-------------------------ADRSL 288 Query: 343 LPVLDSIIKESLR-LSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIY 401 +P L ++ES+R LS + R D + + D ++ ++ + D + Sbjct: 289 IPGL---LEESMRFLSPVAATYRATTRDVEV----AGQRLSADQMVMVWFGAANRDARQF 341 Query: 402 PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILM 461 +P F R ++ FG G C G A E + L + Sbjct: 342 AEPELFDMTR------------------GPNPHLGFGRGIHFCLGGPLARMEGRVALDHL 383 Query: 462 LSYFELELIEGQAKCPPLDQSRAGLGI 488 L F EL + P G+ Sbjct: 384 LDRFP-ELYTDPERPPTFMPGFDTTGV 409 >4MM0-A nrPDB Length = 399 Score = 73.0 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 62/421 (14%), Positives = 120/421 (28%), Gaps = 81/421 (19%) Query: 78 FITNPLSYHKVLCHGKYFDWKKF--HFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQG 135 +T VL ++ + + F S+ D + + Sbjct: 49 LVTRYEDVRFVLSDPRFSVRQDLPGAPRLTEMTF--ESVMTTDPPVHTRLRRLLSRDFTA 106 Query: 136 HALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRR 195 + + + E + ++ + A V F V+ + G + Sbjct: 107 RRIERMRPRLEEIAEGLL-DEMEKKGAPADIVESLAVPFPITVI-----CELLGVPMVDV 160 Query: 196 DTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESI-S 254 F+ + + L + AR+ L L KRE+ S Sbjct: 161 AR-----------FRGWAD----TMVSLTGYSMEDWTAARDALESYLDGLVAAKRENPGS 205 Query: 255 ELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEE 314 +L+S + + D + L++L A S+ ++R P+ + Sbjct: 206 DLLSALVATAAEDNELTDHDVRSLSLILLLAGYEPASNQLGSSVLTLLRFPDRLAELR-- 263 Query: 315 VKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS--LNIRTAKEDFTL 372 +P +L S ++E +R + A R ED T+ Sbjct: 264 ---------------RDPG-----------LLPSAVEELMRYAPAGDGALFRVTLEDVTI 297 Query: 373 HLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKY 432 G +I + + Q + DP + DP + DR Sbjct: 298 ----GDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDR------------------PDN 335 Query: 433 YYMPFGSGATICPGRLFAIHEIKQFLILMLSYF-ELELIEGQAKCPPLDQSR--AGLGIL 489 + G G C G A E++ + +L F L L ++ +G + Sbjct: 336 QHTALGHGIHFCLGAALARVELQVAIGALLRRFPRLALATDESGLRWSSPGSMLSGFAEI 395 Query: 490 P 490 P Sbjct: 396 P 396 >3OFT-A nrPDB Length = 396 Score = 72.2 bits (175), Expect = 5e-13, Method: Composition-based stats. Identities = 39/204 (19%), Positives = 58/204 (28%), Gaps = 51/204 (25%) Query: 273 LEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNP 332 E + +L+ + R+PE + E Sbjct: 222 DEARRMCRNLLFGGLDTVAAMIGMVALHLARHPEDQRLLRERPD---------------- 265 Query: 333 ICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQ 392 ++ + E +R R A D IRK D++ L P Sbjct: 266 ------------LIPAAADELMRRYPTVAVSRNAVADVDAD----GVTIRKGDLVYL-PS 308 Query: 393 LMH-LDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAI 451 ++H LDP + P ++DR L T G GA C G A Sbjct: 309 VLHNLDPASFEAPEEVRFDRGLAPIRHTTM----------------GVGAHRCVGAGLAR 352 Query: 452 HEIKQFLILMLSYF-ELELIEGQA 474 E+ FL L E L +A Sbjct: 353 MEVIVFLREWLGGMPEFALAPDKA 376 >2RFC-A nrPDB Length = 343 Score = 71.4 bits (173), Expect = 8e-13, Method: Composition-based stats. Identities = 40/236 (16%), Positives = 75/236 (31%), Gaps = 59/236 (25%) Query: 233 NAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIP 292 ++ L I +++ N L+ EK K ++++ T Sbjct: 139 YVNNRMVSRLLEIFKSDSHGIINVLAGSSLKNRKLTM---DEKIKYIMLLIIGGNETTTN 195 Query: 293 ATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKE 352 + + NP+ + L+N ++E Sbjct: 196 LIGNMIRVIDENPDI-------IDDALKNRSG------------------------FVEE 224 Query: 353 SLRLSSAS--LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYD 410 +LR S L R A ED ++ + I+K D + +Y + D + +P FK Sbjct: 225 TLRYYSPIQFLPHRFAAEDSYINNKK----IKKGDQVIVYLGSANRDETFFDEPDLFKIG 280 Query: 411 RYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFE 466 R + ++ FG G +C G A E L +L++F+ Sbjct: 281 R-------------------REMHLAFGIGIHMCLGAPLARLEASIALNDILNHFK 317 >4XE3-A nrPDB Length = 407 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 47/359 (13%), Positives = 100/359 (27%), Gaps = 75/359 (20%) Query: 111 HRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEG 170 + D + K + + + + ++ V+ S A V Sbjct: 90 PDGVLAQDPPDHTRLRRLVGKAFTARRVEEMRPRVRSLVDSLLDDMVAHGS-PADLVEFL 148 Query: 171 MYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRT 230 F V+ + G L RD + L + + Sbjct: 149 AVPFPVAVI-----CELLGVPLEDRDLFRTFSDAMLSSTRLTAA---------------E 188 Query: 231 AHNAREKLAESLRHENLQKRES-ISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQAN 289 ++ + Q+R++ +L+ D E + +L A Sbjct: 189 IQRVQQDFMVYMDGLVAQRRDAPTEDLLGALALATDNDDHLTKGEIVNMGVSLLIAGHET 248 Query: 290 TIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSI 349 ++ +L ++ L + SL +P + + Sbjct: 249 SVNQIT-NLVHLL----------------LTERKRYESLVADPALVP-----------AA 280 Query: 350 IKESLRLSS---ASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLT 406 ++E LR + A +R A ED L +R + ++ + D E++ Sbjct: 281 VEEMLRYTPLVSAGSFVRVATEDVELST----VTVRAGEPCVVHFASANRDEEVFDHADE 336 Query: 407 FKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 + R + ++ FG GA C G E+++ L ++ F Sbjct: 337 LDFHRERNP------------------HIAFGHGAHHCIGAQLGRLELQEALSALVRRF 377 >6FSH-A nrPDB Length = 398 Score = 69.9 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 40/352 (11%), Positives = 85/352 (24%), Gaps = 77/352 (21%) Query: 117 MDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCY 176 D + + L + E + ++ A + Sbjct: 91 YDPPEHTRLRHLLTPGFTQRRMRRLAPRIEEIV------TDRLDAMEQAGPPADLIELFA 144 Query: 177 RVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPAL-VAGLPIHMFRTAHNAR 235 + A + G RD +F L L + + A Sbjct: 145 DEVPGAVLCELIGVPRDDRD------------------MFMKLCHGHLDASLSQKRRAAL 186 Query: 236 EKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATF 295 + + + + + T D E + ++ A N Sbjct: 187 GDKFSRYLLAMIARERKDPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIG 246 Query: 296 WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLR 355 + ++R+PE + A + + D + E +R Sbjct: 247 LGVLALLRHPEQIAALRGDDQSA----------------------------DRAVDELIR 278 Query: 356 L--SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYL 413 + RTA ED + + I++ + + + + D + PD R Sbjct: 279 YLTVPYAPTPRTAVEDVMVADQ----VIKEGETVLCSLPMANRDRALLPDADRLDVTR-- 332 Query: 414 DENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 ++ FG G C G +++ + F Sbjct: 333 ----------------TPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRF 368 >3BUJ-A nrPDB Length = 397 Score = 69.9 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 44/342 (12%), Positives = 89/342 (26%), Gaps = 66/342 (19%) Query: 112 RSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGM 171 I D + AL L + + ++RP ++ G Sbjct: 77 DIILFQDEPDHGRLRGVVGPAFSPSALRRLEPVIAGTVDDLLRPALA----------RGA 126 Query: 172 YSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTA 231 + + + G A + V L G R Sbjct: 127 MDVVDELAYPLALRAVLGLLGLPAADWGAVG-------RWSRDVGRTLDRGASAEDMRRG 179 Query: 232 HNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTI 291 H A + A+ + ++R E + M E T + ++ Sbjct: 180 HAAIAEFADYVERALARRRREGGEDLLALMLDAHDRGLMSRNEIVSTVVTFIFTGHETVA 239 Query: 292 PATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIK 351 ++ ++ +P+ + +L ++ Sbjct: 240 SQVGNAVLSLLAHPDQLDLLRRRPD----------------------------LLAQAVE 271 Query: 352 ESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDR 411 E LR ++++ + +E +R+DD++ + + DP Y P F +R Sbjct: 272 ECLRYDP---SVQSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIER 328 Query: 412 YLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHE 453 M FG+G C G A + Sbjct: 329 ------------------DPVPSMSFGAGMRYCLGSYLARTQ 352 >3A1L-A nrPDB Length = 425 Score = 69.1 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 37/238 (15%), Positives = 68/238 (28%), Gaps = 52/238 (21%) Query: 228 FRTAHNAREKLAESLRHENLQKRESISELISLRMFL-NDTLSTFDDLEKAKTHLVVLWAS 286 + A A ++ R E ++ + + + DT S T + +L A Sbjct: 196 YARAEAASQEFTRYFRREVDRRGGDDRDDLLTLLVRARDTGSPLSVDGIVGTCVHLLTAG 255 Query: 287 QANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL 346 T ++ + + + + + E P Sbjct: 256 HETTTNFLAKAVLTLRAHRDVLDELR-------------TTPESTP-------------- 288 Query: 347 DSIIKESLRLSSAS-LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPL 405 + ++E +R R A ED L G ++I + + + DP +PDP Sbjct: 289 -AAVEELMRYDPPVQAVTRWAYEDIRL----GDHDIPRGSRVVALLGSANRDPARFPDPD 343 Query: 406 TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLS 463 R + + FG G C G A E + L +L Sbjct: 344 VLDVHRAAERQ------------------VGFGLGIHYCLGATLARAEAEIGLRALLD 383 >5NWS-A nrPDB Length = 435 Score = 68.7 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 64/447 (14%), Positives = 125/447 (27%), Gaps = 85/447 (19%) Query: 50 ANPLEFLRANQRKHGHVFTCKLM-GKYVHFITNPLSYHKVLCHGKYFDWKKFHF------ 102 A+P + + G V + + G V F+T VL ++ + Sbjct: 34 ADPFTGYGRLRER-GPVVRGRFVDGTPVWFVTRYDDVRAVLRDPRFVNTPSPVPGEGGAD 92 Query: 103 -----------ATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQR 151 + + SI D + + + L + R Sbjct: 93 PREGMMDLLNVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRILGLRPGIERIADR 152 Query: 152 IMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQ 211 ++ + T + + + G T +L+ +++ Sbjct: 153 LL---AELPRREEEDGTVDLLEHFAYPLSITVICELVGIPAT-----------DLERWRE 198 Query: 212 FDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFD 271 + ++ H F + +L E R + +SELI + +D Sbjct: 199 WGGDLVSMRPERLRHSFPVMIDYCHRLIEQRR--AALTDDLLSELIRAQ---DDDGGRLS 253 Query: 272 DLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGN 331 D+E L ++ A + ++ +P Sbjct: 254 DIETVTMILTLVLAGHETSAHLIGNGTAALLTHP-------------------------- 287 Query: 332 PICLSQAELNDLP-VLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALY 390 A L P +L + E +R + R T LE + + D + L Sbjct: 288 ---GQWALLRKDPALLPRAVHELMRWCGSVHVAR--LRYATEDLELAGTPVARGDAVQLV 342 Query: 391 PQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA 450 + DP Y DP R+ + + ++ FG G C G A Sbjct: 343 LVSANFDPRHYSDPDRLDITRHQEGQAEN--------------HVGFGHGIHYCLGATLA 388 Query: 451 IHEIKQFLILMLSYF-ELELIEGQAKC 476 E + L +L + +L L +G + Sbjct: 389 RQEGEVALARLLETYPDLALADGDPEV 415 >3IVY-A nrPDB Length = 433 Score = 68.4 bits (165), Expect = 8e-12, Method: Composition-based stats. Identities = 46/371 (12%), Positives = 96/371 (25%), Gaps = 78/371 (21%) Query: 117 MDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCY 176 MD + + A+ L + + E Q+I ++ S Sbjct: 119 MDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAAAGSGDFVEQVSCELPL-- 176 Query: 177 RVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNARE 236 + G + + + + + P P Sbjct: 177 -----QAIAGLLG----VPQEDRGKLFHWSNEMTGNED--PEYAHIDPKASSAELIGYAM 225 Query: 237 KLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFW 296 K+AE ++++ + + D E +++ A T + Sbjct: 226 KMAEEKAKNPA------DDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQ 279 Query: 297 SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL 356 + +P+ ++V+ E +R Sbjct: 280 GMMAFAEHPD-QWELYKKVRPETAAD-----------------------------EIVRW 309 Query: 357 -SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDE 415 + + RTA D+ L I+K + ++ + + D E++ DP TF R Sbjct: 310 ATPVTAFQRTALRDYELS----GVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILR---- 361 Query: 416 NGKTKTTFYCNGLKLKYYYMPFGS-GATICPGRLFAIHEIKQFLILMLSYFELELIEGQA 474 ++ FG GA C G A I + + Sbjct: 362 --------------NPNPHVGFGGTGAHYCIGANLARMTINLIFNAVADHM-----PDLK 402 Query: 475 KCPPLDQSRAG 485 ++ R+G Sbjct: 403 PISAPERLRSG 413 >4Z5Q-A nrPDB Length = 423 Score = 67.6 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 60/436 (13%), Positives = 118/436 (27%), Gaps = 82/436 (18%) Query: 35 ENGLIPYLGC-ALQFGANPLEFLRANQRKHGHVFTCKL-MGKYVHFITNPLSYHKVLCHG 92 P+ G L+ + + G +L G+ +T VL Sbjct: 34 APVAYPFTGSEGLELSQSYAKLFED-----GDPIRVQLPFGEPAWLVTRYDDARFVLTDR 88 Query: 93 KY--FDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQ 150 ++ + SI MD + K + S + L Sbjct: 89 RFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRTLVSKAFTPRRIESKRAWI-GELA 147 Query: 151 RIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFK 210 + + + A V + V+ + G + + + D Sbjct: 148 AGLVADMKAGGAPAELVGSYALAIPVTVI-----CELLG----VPEDDRTRLRGWCDAAL 198 Query: 211 QFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTF 270 + L + F E L + R E + + S LI R + Sbjct: 199 STGE----LTDEECVQSFMDLQKYFEDLVKERRAEP--RDDLTSALIEARDAHDRLAEP- 251 Query: 271 DDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEG 330 E + +L T + + + E Sbjct: 252 ---ELIGLCISILIGGFETTASEISSFVHVLQQRRELWTRL------------------- 289 Query: 331 NPICLSQAELNDLPVLDSIIKESLRLSSAS---LNIRTAKEDFTLHLEDGSYNIRKDDII 387 A+ +P + ++E LR + ++ R A ED T+ G +R+ + + Sbjct: 290 ------CADPEAIP---AAVEELLRFVPFAANGISPRYALEDMTV----GGVLVREGEPV 336 Query: 388 ALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGR 447 + ++ D ++ + DR +M FG GA C G Sbjct: 337 IVDTSAVNRDGLVFDNADEVVIDR------------------ADNRHMVFGHGAHHCLGA 378 Query: 448 LFAIHEIKQFLILMLS 463 A E+++ L ++ Sbjct: 379 HLARVELQEALKALVE 394 >4TX3-A nrPDB Length = 404 Score = 67.2 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 32/255 (12%), Positives = 68/255 (26%), Gaps = 53/255 (20%) Query: 214 KVFPAL-VAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDD 272 +F L L + A + + + + + + T D Sbjct: 170 AMFLQLCHRHLDASLSARKRAAAGEAFARYLVAMMARERKDPGDGFIGSIVAEHGDTITD 229 Query: 273 LEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNP 332 E + ++ A N + ++R+PE + A + + Sbjct: 230 EELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSA-------------- 275 Query: 333 ICLSQAELNDLPVLDSIIKESLRL--SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALY 390 D + E +R + RTA ED + + I++ + + Sbjct: 276 --------------DRAVDELIRYLTVPYAPTPRTAVEDVMVADQ----VIKEGETVLCS 317 Query: 391 PQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA 450 + + D + PD R ++ FG G C G Sbjct: 318 LPMANRDRALLPDADRLDVTR------------------TPVPHVAFGHGIHHCLGAALT 359 Query: 451 IHEIKQFLILMLSYF 465 +++ + F Sbjct: 360 RLQLRIAYTALWRRF 374 >6GII-A nrPDB Length = 479 Score = 67.2 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 49/435 (11%), Positives = 108/435 (24%), Gaps = 85/435 (19%) Query: 47 QFGANPLEFLRANQRK----HGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHF 102 + A+P +F+R + + + ++ +Y ++ F Sbjct: 75 AYMADPAQFVRWAREQVPIFYAPKLNYWVVTRYDTI-------KQIFRDPVTFSPSNVLQ 127 Query: 103 ATSAKAFGHRSIDPMDG------------NTTENINDTFIKTLQGHALNSLTESMMENLQ 150 + + + R + G ++ L + E ++ Sbjct: 128 SFAQPSAEVRQVLERYGYAFNRTLVNEDEPMHLERRRVLMEPFASEHLAEHEPMVRELVR 187 Query: 151 RIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFK 210 R + + + + + L G + D +K Sbjct: 188 RAVNRFIDT-------GRADLVDQMIWEVPFTVALHFLG--VDDDDREKMRRFAIAHTVN 238 Query: 211 QFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTF 270 F + P + + + E L + R + + Sbjct: 239 AFGRPSPEEQLAVAETVGQFWQFCGEVLEKMRR-----TADGPGWMRYSIRQQKLYPDVV 293 Query: 271 DDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEG 330 D ++ A+ T+ AT +L ++ + E V R + + Sbjct: 294 TDSYLHSMMQAIIVAAHETTVFATTNALKTLLEH--------ETVWREICADPSLIP--- 342 Query: 331 NPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALY 390 + +E LR + R T +E + I + Sbjct: 343 -----------------AAAEECLRYNGPVAGWRRR---TTREVEVEGVRLPVGANILMV 382 Query: 391 PQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA 450 + D + DP F R ++ FG GA C GR Sbjct: 383 VASANHDSAHFDDPEFFDIGR-----------------SNASEHLNFGYGAHQCLGRNLG 425 Query: 451 IHEIKQFLILMLSYF 465 E++ + + Sbjct: 426 RMEMQIMIEELSRRL 440 >3OO3-A nrPDB Length = 384 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 57/453 (12%), Positives = 121/453 (26%), Gaps = 89/453 (19%) Query: 47 QFGANPLEFLRANQRKHGHVFTCK----LMGKYVHFITNPLSYHKVLCHGKYFDWKKFHF 102 + +P+ Q K G + + G+ +T +L + F + Sbjct: 9 RLRLDPVPEFEELQ-KAGPLHEYDTEPGMDGRKQWLVTGHDEVRAILADHERFSSMRPVD 67 Query: 103 ATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSK 162 + +A + D + T + L + E ++ + S + Sbjct: 68 DEADRALLPGILQAYDPPDHTRLRRTVAPAYSARRMERLRPRIEEIVEECLDDFESVGA- 126 Query: 163 TAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAG 222 +V + + G + I + ++ + L Sbjct: 127 PVDFVRHAAWPIPAYI-----ACEFLGVPRDDQAELSRMIRESRESRLPRQRTLSGL--- 178 Query: 223 LPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVV 282 + + KR + + + + + + D E A Sbjct: 179 --------------GIVNYTKRLTSGKRRDPGDGMI-GVIVREHGAEISDEELAGLAEGN 223 Query: 283 LWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELND 342 L + ++ ++ +P+ M E+ + Sbjct: 224 LIMAAEQMAAQLAVAVLLLVTHPDQMALLREKPE-------------------------- 257 Query: 343 LPVLDSIIKESLRLSSA--SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEI 400 ++DS +E LR +S + R A D + D I D++ + P Sbjct: 258 --LIDSATEEVLRHASIVEAPAPRVALADVRMAGRD----IHAGDVLTCSMLATNRAPG- 310 Query: 401 YPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLIL 460 F R K +M FG G C G A +++ L Sbjct: 311 ----DRFDITR------------------EKATHMAFGHGIHHCIGAPLARLQLRVALPA 348 Query: 461 MLSYF---ELELIEGQAKCPPLDQSRAGLGILP 490 ++ F L + E + P + + LP Sbjct: 349 VVGRFPSLRLAVPEEDLRFKPGRPAPFAVEELP 381 >5DQN-A nrPDB Length = 426 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 49/351 (13%), Positives = 92/351 (26%), Gaps = 73/351 (20%) Query: 117 MDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCY 176 MD + + A+ L + + Q+I + + + Sbjct: 102 MDAPQHTRLRKIISRGFTPRAIGRLEDELRSRAQKIAQTAAAQGAGDFVEQVSCELPL-- 159 Query: 177 RVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNARE 236 + G RD + + + P P + Sbjct: 160 -----QAIAELLGVPQDDRDK----LFRWSNEMTAGED--PEYADVDPAMSSFELISYAM 208 Query: 237 KLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFW 296 K+AE ++++ + + D E +++ A T + Sbjct: 209 KMAEERAVNP------TEDIVTKLIEADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITH 262 Query: 297 SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL 356 + +NP+ + +E T + E +R Sbjct: 263 GMIAFAQNPDQWELYKKERPETAAD------------------------------EIVRW 292 Query: 357 -SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDE 415 + S RTA ED L G I+K + + + + D E++ DP TF R Sbjct: 293 ATPVSAFQRTALEDVEL----GGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILR---- 344 Query: 416 NGKTKTTFYCNGLKLKYYYMPFGS-GATICPGRLFAIHEIKQFLILMLSYF 465 ++ FG GA C G A I + Sbjct: 345 --------------SPNPHVGFGGTGAHYCIGANLARMTINLIFNAIADNM 381 >2FR7-A nrPDB Length = 412 Score = 66.4 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 34/241 (14%), Positives = 63/241 (26%), Gaps = 49/241 (20%) Query: 224 PIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVL 283 P + R + R ++ E Q+ + E +L Sbjct: 190 PPNELRQSAIERSAPHQAYVAEQCQRPNLAPGGFGACIHAFSDTGEITPEEAPLLVRSLL 249 Query: 284 WASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDL 343 A T+ +++ + R P+ + + V E Sbjct: 250 SAGLDTTVNGIAAAVYCLARFPDEFARLRADPSLARNAFEEAVRFE-------------- 295 Query: 344 PVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPD 403 S RT D L I + + + ++ + DP + D Sbjct: 296 -------------SPVQTFFRTTTRDVEL----AGATIGEGEKVLMFLGSANRDPRRWDD 338 Query: 404 PLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLS 463 P + R ++ FGSG +C G+L A E + L + Sbjct: 339 PDRYDITR------------------KTSGHVGFGSGVHMCVGQLVARLEGEVVLAALAR 380 Query: 464 Y 464 Sbjct: 381 K 381 >5LIV-A nrPDB Length = 450 Score = 66.4 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 58/411 (14%), Positives = 116/411 (28%), Gaps = 78/411 (18%) Query: 77 HFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGH 136 P+ K Y D F + + M G+ + + Sbjct: 86 TAFGMPILLRKSHITTAYRDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLPR 145 Query: 137 ALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFG---RDLT 193 A++ E + + + ++ + + + RV+ E +FG L Sbjct: 146 AVSQYEERFVRPISEQVVDRLAGKPRVDL-LEDFAMELPRRVIGE-----LFGFPAEKLH 199 Query: 194 RRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESI 253 D + +L L V + A + + ++ Sbjct: 200 ETDERVRAMLRGLVRMHDPAAV-------------AESQRAYGETLGLITEVVERESRDT 246 Query: 254 SELISLRMFLNDTLSTFDDLEKAKTHLVVL-WASQANTIPATFWSLFQMIRNPEAMKAAT 312 S+ + + D +E ++ ++ L T ++ ++ +P+ + Sbjct: 247 SDTLLGEILRTLKAEHMDTIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVR 306 Query: 313 EEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASL-NIRTAKEDFT 371 + +P +L + I+E +R +S +R + D Sbjct: 307 Q-----------------DPS-----------LLPAAIEEGMRWCPSSFGVLRMVERDVR 338 Query: 372 LHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLK 431 L + + ++ L + D YP P + DR K N Sbjct: 339 LDDQ----ALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR--------KPLPAANV---- 382 Query: 432 YYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQS 482 FG GA C G A E + L +L+ F G P S Sbjct: 383 -----FGGGAHFCVGAPLARMEARVGLQALLARF-----PGLRAVPEERPS 423 >6HQW-A nrPDB Length = 445 Score = 66.4 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 29/227 (12%), Positives = 65/227 (28%), Gaps = 56/227 (24%) Query: 236 EKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATF 295 ++L + + M ++ ++ E ++++ T Sbjct: 240 QRLWGARMQAPPSGD------LISMMIHSEAMNHMSPQEFMGNLVLLIVGGNDTTRNTMS 293 Query: 296 WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLR 355 + + + P+ + E + NA ++E +R Sbjct: 294 GIVHALDKFPD-QRELLERDASLIPNA---------------------------VQECIR 325 Query: 356 L-SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLD 414 + + RTA D L I+ + + L+ + D ++ +P DR Sbjct: 326 YVTPLAHMRRTATADTEL----FGNQIKAGEKVILWYISANRDETVFENPDKLMVDR--- 378 Query: 415 ENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILM 461 ++ FG G C G A +++ L M Sbjct: 379 --------------PNARRHLSFGHGIHRCVGARLAELQLRILLEEM 411 >6F88-A nrPDB Length = 400 Score = 65.3 bits (157), Expect = 6e-11, Method: Composition-based stats. Identities = 57/411 (13%), Positives = 116/411 (28%), Gaps = 78/411 (18%) Query: 77 HFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGH 136 P+ K Y D F + + M G+ + + Sbjct: 36 TAFGMPILLRKSHITTAYRDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLPR 95 Query: 137 ALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFG---RDLT 193 A++ E + + + ++ + + + RV+ E +FG L Sbjct: 96 AVSQYEERFVRPISEQVVDRLAGKPRVDL-LEDFAMELPRRVIGE-----LFGFPAEKLH 149 Query: 194 RRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESI 253 D + +L L V + A + + ++ Sbjct: 150 ETDERVRAMLRGLVRMHDPAAV-------------AESQRAYGETLGLITEVVERESRDT 196 Query: 254 SELISLRMFLNDTLSTFDDLEKAKTHLVVL-WASQANTIPATFWSLFQMIRNPEAMKAAT 312 S+ + + D +E ++ ++ L T ++ ++ +P+ + Sbjct: 197 SDTLLGEILRTLKAEHMDTIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVR 256 Query: 313 EEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASL-NIRTAKEDFT 371 + +P +L + I+E +R ++ +R + D Sbjct: 257 Q-----------------DPS-----------LLPAAIEEGMRWCPSNFGVLRMVERDVR 288 Query: 372 LHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLK 431 L + + ++ L + D YP P + DR K N Sbjct: 289 LDDQ----ALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR--------KPLPAANV---- 332 Query: 432 YYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQS 482 FG GA C G A E + L +L+ F G P S Sbjct: 333 -----FGGGAHFCVGAPLARMEARVGLQALLARF-----PGLRAVPEERPS 373 >5DE9-A nrPDB Length = 410 Score = 65.3 bits (157), Expect = 7e-11, Method: Composition-based stats. Identities = 36/232 (15%), Positives = 71/232 (30%), Gaps = 48/232 (20%) Query: 233 NAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIP 292 A+ ++ + +S E ++ + E +++ +A T Sbjct: 190 RAKNEMNAYFSDLIGLRSDSAGEDVTSLLGAAVGRDEITLSEAVGLAVLLQIGGEAVTNN 249 Query: 293 ATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKE 352 + ++ PE + E E P + L +P +++ Sbjct: 250 SGQ-MFHLLLSRPELAERLRSE-------------PEIRPRAID-ELLRWIPHRNAV--- 291 Query: 353 SLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRY 412 R A ED + IR D + + + DPE++PDP ++R Sbjct: 292 --------GLSRIALEDVEIK----GVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFER- 338 Query: 413 LDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSY 464 ++ FG G CPG + A E + + +L Sbjct: 339 -----------------SPNPHVSFGFGPHYCPGGMLARLESELLVDAVLDR 373 >5KYO-A nrPDB Length = 430 Score = 64.5 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 42/262 (16%), Positives = 77/262 (29%), Gaps = 56/262 (21%) Query: 232 HNAREKLAESLRHENLQKRESISELISLRMFLNDTLS-TFDDLEKAKTHLVVLWASQANT 290 + ++ E LR +R E + RM + D+E + VL Sbjct: 216 DDVTKQFREYLRPVIEARRIKPGEDMISRMINGEVGGRPLTDIEAENICIQVLVGGLDTV 275 Query: 291 IPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSII 350 + ++ + ++ +A +P ++D + Sbjct: 276 VNMLGFTFSHLAKDHALRRAI-----------------AADPS-----------LIDDAL 307 Query: 351 KESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYD 410 E R + R D E ++ D++ ++ +D DPL F+ Sbjct: 308 LEFFRRFPVVSSAREVLRD----QEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLG 363 Query: 411 RYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFL-ILMLSYFELEL 469 R + FG G+ CPG A E+K L E + Sbjct: 364 R------------------KARQHSTFGKGSHTCPGAHLARMEMKVVLREWFARIPEFRI 405 Query: 470 IEGQAKCPPLDQSRAGLGILPP 491 + PL S +G + P Sbjct: 406 EDDA----PLRYSNGIVGSVKP 423 >4DO1-A nrPDB Length = 410 Score = 64.5 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 35/241 (14%), Positives = 71/241 (29%), Gaps = 50/241 (20%) Query: 224 PIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVL 283 P + +TA R ++ +E Q+ + E +L Sbjct: 189 PNELRQTAIE-RSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLL 247 Query: 284 WASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDL 343 A T+ +++ + R P ++ +P Sbjct: 248 SAGLDTTVNGIGAAVYCLARFPGELQRLR-----------------SDPT---------- 280 Query: 344 PVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPD 403 + + +E++R S T +E G I + + + ++ + DP + D Sbjct: 281 -LARNAFEEAVRFESPVQTFFRT---TTREVELGGAVIGEGEKVLMFLGSANRDPRRWSD 336 Query: 404 PLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLS 463 P + R ++ FGSG +C G+L A E + L + Sbjct: 337 PDLYDITR------------------KTSGHVGFGSGVHMCVGQLVARLEGEVMLSALAR 378 Query: 464 Y 464 Sbjct: 379 K 379 >6M7L-A nrPDB Length = 404 Score = 63.7 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 39/240 (16%), Positives = 68/240 (28%), Gaps = 57/240 (23%) Query: 229 RTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQA 288 + + E + L M D + D E A VV+ +S Sbjct: 188 KRRRVLNGHAYLAYMRELAARLRRDPGDGMLGMVARDHGADISDEELAGLCAVVMNSSVE 247 Query: 289 NTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDS 348 T ++ +PE E + + + Sbjct: 248 QTESCLAAGTLLLLEHPEQFALLRERPE----------------------------LGEQ 279 Query: 349 IIKESLRLSSA--SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHL-DPEIYPDPL 405 ++E +R S L+ RTA ED + G I+K + + + DP + Sbjct: 280 AVEEIVRYLSVFEGLDPRTATEDVEI----GGQVIKKGEAVFCSLLAANRADPAL----D 331 Query: 406 TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 F R + ++ FG G C G A E++ ++S F Sbjct: 332 GFDITR------------------KESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRF 373 >5OMS-A nrPDB Length = 409 Score = 63.0 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 54/421 (12%), Positives = 116/421 (27%), Gaps = 64/421 (15%) Query: 45 ALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFAT 104 Q NP E + + F L + + +V D++ Sbjct: 19 MTQLERNPYEVYERLRAEAPLAFVPVLGS---YVASTAEVCREVATSP---DFEAVITPA 72 Query: 105 SAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTA 164 + FGH +I ++G+ ++ LQ ++ + ++ + R ++ Sbjct: 73 GGRTFGHPAIIGVNGDIHADLRSMVEPALQPAEVDRWIDDLVRPIARRYLERFEND---- 128 Query: 165 AWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLP 224 E + +C V + + +++ + L+ V P Sbjct: 129 -GHAELVAQYCEPVSVRSLGDLLGLQEVDS--DKLREWFAKLNRSFTNAAVDENGEFANP 185 Query: 225 IHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLND-TLSTFDDLEKAKTHL-VV 282 F A+ ++ + + E + + D E + V Sbjct: 186 -EGFAEGDQAKAEIRAVVDPLIDKWIEHPDDSAISHWLHDGMPPGQTRDREYIYPTIYVY 244 Query: 283 LWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELND 342 L + +L + PE ++ + +P + +A Sbjct: 245 LLGAMQEPGHGMASTLVGLFSRPEQLEEVVD-----------------DPTLIPRA---- 283 Query: 343 LPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYP 402 I E LR +S + T + ++ + L + D Y Sbjct: 284 -------IAEGLRWTSPIWS--ATARISTKPVTIAGVDLPAGTPVMLSYGSANHDTGKYE 334 Query: 403 DPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILML 462 P + R ++ FG+G C G FA H ++ L + Sbjct: 335 APSQYDLHR------------------PPLPHLAFGAGNHACAGIYFANHVMRIALEELF 376 Query: 463 S 463 Sbjct: 377 E 377 >2WM5-A nrPDB Length = 435 Score = 62.6 bits (150), Expect = 4e-10, Method: Composition-based stats. Identities = 39/244 (15%), Positives = 72/244 (29%), Gaps = 50/244 (20%) Query: 248 QKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEA 307 ++ +L S + E A ++++ A T A + + R PE Sbjct: 237 RRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYPEQ 296 Query: 308 MKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAK 367 + A ++E +R +S + +R Sbjct: 297 RDRWWSDFDGLAPTA---------------------------VEEIVRWASPVVYMRRT- 328 Query: 368 EDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNG 427 T +E + D ++L+ + D + DP TF R Sbjct: 329 --LTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLAR---------------- 370 Query: 428 LKLKYYYMPF-GSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGL 486 ++ F G GA C G A EI+ + +++ + L Q G+ Sbjct: 371 --NPNPHLGFGGGGAHFCLGANLARREIRVAFDELRRQMP-DVVATEEPARLLSQFIHGI 427 Query: 487 GILP 490 LP Sbjct: 428 KTLP 431 >6G71-A nrPDB Length = 405 Score = 62.2 bits (149), Expect = 5e-10, Method: Composition-based stats. Identities = 27/153 (17%), Positives = 50/153 (32%), Gaps = 25/153 (16%) Query: 340 LNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPE 399 L D + ++ +ES+R + I + E Y I + + L + D Sbjct: 263 LRDPKLWGAVFEESIRWVAP---IGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRS 319 Query: 400 IYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLI 459 ++ DP F +R ++ FG G +C G A ++ + Sbjct: 320 VWSDPDRFDIER------------------GSEAHLAFGKGVHVCLGAWAARSQVADVGL 361 Query: 460 LMLSYFELELIEGQAKCPPLDQSRAGLGILPPL 492 L ++G P + + G PL Sbjct: 362 PAL----FSRLKGLRLDPNQEATHGGWVFRGPL 390 >2X9P-A nrPDB Length = 404 Score = 61.8 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 39/246 (15%), Positives = 74/246 (30%), Gaps = 61/246 (24%) Query: 247 LQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPE 306 ++ + + + + L+ + A + +L+A + + + +P+ Sbjct: 206 VEHKRAEPGPDIISRLNDGELT---EDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPD 262 Query: 307 AMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS---LNI 363 AA + V+ ++E LR + A L Sbjct: 263 QRAAALADPD----------------------------VMARAVEEVLRTARAGGSVLPP 294 Query: 364 RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTF 423 R A ED +E G IR D++ L + D + P F R Sbjct: 295 RYASED----MEFGGVTIRAGDLVLFDLGLPNFDERAFTGPEEFDAAR------------ 338 Query: 424 YCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSR 483 ++ FG G C G A E++ + + + P++Q R Sbjct: 339 ------TPNPHLTFGHGIWHCIGAPLARLELRTMFTKLFTR-----LPELRPELPVEQLR 387 Query: 484 AGLGIL 489 G L Sbjct: 388 LKEGQL 393 >6CVC-A nrPDB Length = 433 Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 38/245 (15%), Positives = 71/245 (28%), Gaps = 52/245 (21%) Query: 248 QKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEA 307 ++ +L + + E A ++++ A T A + + R P+ Sbjct: 234 RRVNHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNAISHGMLALSRYPDE 293 Query: 308 MKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL-SSASLNIRTA 366 + + + ++E +R S RT Sbjct: 294 RAKWWSDFDG---------------------------LAATAVEEIVRWASPVVYMRRTL 326 Query: 367 KEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCN 426 +D L + D + L+ + D E + DP TF R + Sbjct: 327 SQDVDL----RGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQ---------- 372 Query: 427 GLKLKYYYMPFGSG-ATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAG 485 + FG G A C G A EI+ + +++ + L Q G Sbjct: 373 --------VGFGGGGAHFCLGANLARREIRVVFDELRRQMP-DVVATEEPARLLSQFIHG 423 Query: 486 LGILP 490 + LP Sbjct: 424 IKRLP 428 >3NV6-A nrPDB Length = 452 Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 34/224 (15%), Positives = 59/224 (26%), Gaps = 51/224 (22%) Query: 254 SELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATE 313 +LI+L + + ++L + + + + R+PE + Sbjct: 259 DDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVVNFLSFFMIHLARHPELVAELRS 318 Query: 314 EVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLH 373 + + + A E R R +D Sbjct: 319 DPLKLMRGAE----------------------------EMFRRFPVVSEARMVAKD---- 346 Query: 374 LEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYY 433 E +++ D+I L L LD P+P + R Sbjct: 347 QEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSR------------------RSIS 388 Query: 434 YMPFGSGATICPGRLFAIHEIKQFLILMLSYF-ELELIEGQAKC 476 + FG G C G A E+ L L E EG+ Sbjct: 389 HSTFGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPI 432 >5HH3-A nrPDB Length = 397 Score = 60.7 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 47/395 (11%), Positives = 90/395 (22%), Gaps = 76/395 (19%) Query: 72 MGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIK 131 G+ T +VL F + + T+A + D + Sbjct: 50 GGRTAWLATGYDEIRQVLS-SDDFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVAP 108 Query: 132 TLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRD 191 + + +Q + ++ A + G Sbjct: 109 AFAVRRMQKFQPQVERVVQDSL------DAIEALGGPVDFVPRFGWSVATTATCDFLG-- 160 Query: 192 LTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRE 251 RD Q + +L A + A K + + R Sbjct: 161 -IPRDDQ--------------ADLARSLHASRTERSGKRRTAAGNKFMTYMNKMTARTRR 205 Query: 252 SISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAA 311 + + + + + D E V+ A + M +PE Sbjct: 206 DPGDDM-FGVVVREYGDEITDAELTGVAAFVMGAGADQVARFLAAGAWLMADDPEQFALL 264 Query: 312 TEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFT 371 E+ + E +R + +T T Sbjct: 265 REKPDTV----------------PDWLD------------EVIRYLTTD--EKTHPRVAT 294 Query: 372 LHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLT-FKYDRYLDENGKTKTTFYCNGLKL 430 + G + I+ D + + +P P F R E Sbjct: 295 DDVRIGDHLIKAGDTVTCSLLAANRRN--FPRPEDRFDITRVRPE--------------- 337 Query: 431 KYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 ++ FG G C GR A + + + F Sbjct: 338 ---HLAFGHGIHHCLGRSLAELVFRTAIPALAHRF 369 >5H1Z-A nrPDB Length = 407 Score = 60.3 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 29/208 (13%), Positives = 61/208 (29%), Gaps = 48/208 (23%) Query: 257 ISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVK 316 + M +D ++ D +E ++++ T + + P+ Sbjct: 217 LISMMIHSDAMAEMDQMEFLGNLILLIVGGNDTTRNTMSAVAYGLDLFPDQRAKL----- 271 Query: 317 RTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLED 376 E +P + + ++E +R + ++R T+ E Sbjct: 272 ------------EADPSMIP-----------NTVQEIIRWQTPLAHMRRT---ATVDSEL 305 Query: 377 GSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMP 436 I+ D +AL+ + D ++ + DR ++ Sbjct: 306 EGQQIKAGDKLALWYISANRDESVFENADRIIVDR-----------------PNARRHLA 348 Query: 437 FGSGATICPGRLFAIHEIKQFLILMLSY 464 FG G C G A +I L M Sbjct: 349 FGHGIHRCVGARLAELQIAVLLEEMAKR 376 >4FB2-A nrPDB Length = 398 Score = 59.5 bits (142), Expect = 4e-09, Method: Composition-based stats. Identities = 43/388 (11%), Positives = 96/388 (24%), Gaps = 75/388 (19%) Query: 78 FITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHA 137 + V+ + K F K F + D + K A Sbjct: 48 VVAGYKEIQAVIQNTKAFSNKGVTFPRYETGEFELMMAGQDDPVHKKYRQLVAKPFSPEA 107 Query: 138 LNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDT 197 + TE + ++ ++ + AA T ++ R T Sbjct: 108 TDLFTEQLRQSTNDLIDARIELGEGDAA--------------------TWLANEIPARLT 147 Query: 198 QKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESIS-EL 256 L D V+ P +L R ++R + ++ Sbjct: 148 AILLGLPPEDGDTYRRWVWAITHVENPEE----GAEIFAELVAHARTLIAERRTNPGNDI 203 Query: 257 ISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVK 316 +S + + + + ++L NT +++ + E + Sbjct: 204 MSRVIMSKIDGESLSEDDLIGFFTILLLGGIDNTARFLSSVFWRLAWDIELRRRL----- 258 Query: 317 RTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLED 376 + ++ + + E LR ++ R ++ T+ Sbjct: 259 -----------------------IAHPELIPNAVDELLRFYGPAMVGRLVTQEVTV---- 291 Query: 377 GSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMP 436 G ++ L+ + D + P +R ++ Sbjct: 292 GDITMKPGQTAMLWFPIASRDRSAFDSPDNIVIER------------------TPNRHLS 333 Query: 437 FGSGATICPGRLFAIHEIKQFLILMLSY 464 G G C G E + + L Sbjct: 334 LGHGIHRCLGAHLIRVEARVAITEFLKR 361 >5D3U-A nrPDB Length = 427 Score = 59.1 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 30/217 (13%), Positives = 63/217 (29%), Gaps = 52/217 (23%) Query: 250 RESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMK 309 +++ ++ + + + + L+A T + RNP ++ Sbjct: 234 PDTVIARLAAAQDGLTETTPEQTVHQLALVFIALFAP--TTPGSLSSGTLAFARNPRQVE 291 Query: 310 AATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS-LNIRTAKE 368 + D+ E LR ++++ R A + Sbjct: 292 RFLADQACV----------------------------DNTANEVLRYNASNQFTWRVAAK 323 Query: 369 DFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGL 428 D + G I +AL+ + D ++ P F DR Sbjct: 324 DVEM----GGVRIEAGQTLALFLGSANRDANMFERPNDFDLDR----------------- 362 Query: 429 KLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 ++ FG G C ++K F + +L+ F Sbjct: 363 PNSARHLSFGQGVHACLAAQLISLQLKWFYVALLNRF 399 >2QBO-A nrPDB Length = 421 Score = 59.1 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 43/243 (17%), Positives = 75/243 (30%), Gaps = 52/243 (21%) Query: 233 NAREKLAESLRHENLQKRESIS-ELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTI 291 A+E L + L Q+R+ + IS+ E + ++L + Sbjct: 196 EAKEALYDYLIPIIEQRRQKPGTDAISIVANGQVNGRPITSDEAKRMCGLLLVVGLDTVV 255 Query: 292 PATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIK 351 +S+ + ++PE + E +R + + Sbjct: 256 NFLSFSMEFLAKSPEHRQELIERPERIP----------------------------AACE 287 Query: 352 ESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDR 411 E LR S + R D+ H ++K D I L L LD P+ + R Sbjct: 288 ELLRRFSLVADGRILTSDYEFH----GVQLKKGDQILLPQMLSGLDERENACPMHVDFSR 343 Query: 412 YLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF-ELELI 470 K + FG G+ +C G+ A EI L L+ + + Sbjct: 344 ------------------QKVSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIA 385 Query: 471 EGQ 473 G Sbjct: 386 PGA 388 >4C9K-A nrPDB Length = 421 Score = 57.6 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 38/255 (14%), Positives = 70/255 (27%), Gaps = 52/255 (20%) Query: 224 PIHMFRTAHNAREKLAESLRHENLQKRESIS-ELISLRMFLNDTLSTFDDLEKAKTHLVV 282 P R+ A + E + +R +LI+ + + D ++ Sbjct: 194 PEEQGRSLEAANKGFFEYVAPIIAARRGGSGTDLITRILNVEIDGKPMPDDRALGLVSLL 253 Query: 283 LWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELND 342 L + + + + R+PE + E + Sbjct: 254 LLGGLDTVVNFLGFMMIYLSRHPETVAEMRREPLK------------------------- 288 Query: 343 LPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYP 402 L ++E R + + R D +E +++ D+I L L LD + Sbjct: 289 ---LQRGVEELFRRFAVVSDARYVVSD----MEFHGTMLKEGDLILLPTALHGLDDRHHD 341 Query: 403 DPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLI-LM 461 DP+T R + F G C G A E+ L + Sbjct: 342 DPMTVDLSR------------------RDVTHSTFAQGPHRCAGMHLARLEVTVMLQEWL 383 Query: 462 LSYFELELIEGQAKC 476 E L + Sbjct: 384 ARIPEFRLKDRAVPI 398 >4PWV-A nrPDB Length = 446 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 27/117 (23%), Positives = 42/117 (35%), Gaps = 23/117 (19%) Query: 346 LDSIIKESLRL-SSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDP 404 L+S +E LR + A R A D LH + I D++ L+ + D E++ DP Sbjct: 303 LESATEEVLRWATPAMHFGRRAVTDMELHGQ----VIAAGDVVTLWNNSANRDEEVFADP 358 Query: 405 LTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILM 461 F +R ++ FG G C G E+ L + Sbjct: 359 YAFDLNR------------------SPNKHITFGYGPHFCLGAYLGRAEVHALLDAL 397 >3WEC-A nrPDB Length = 419 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 63/431 (14%), Positives = 116/431 (26%), Gaps = 81/431 (18%) Query: 48 FGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSA- 106 F A+P + + + L V T+ + GK F F ++ Sbjct: 22 FKADPYPVYARLRTEL-PIHRSALGAWIVADYTSCDKVLRSRLFGKDFANSTFFDHLTSM 80 Query: 107 -----KAFGHRSIDPMDGN--TTENINDTFIKTLQGHAL-NSLTESMMENLQRIMRPPVS 158 F ID T+ T ++ L A S T SM + + V Sbjct: 81 MGEDMPPFLGLGIDGDARPFMLTDPPEHTRLRGLVSDAFTRSTTTSMDDIVLSAASSAVR 140 Query: 159 SNSKTAAWVTEGMYSFCYRVMFEAGYLTIFG--RDLTRRDTQKAHILNNLDNFKQFDKVF 216 V+E F V+ +I G R ++ ++++ + Sbjct: 141 HLEHCTDAVSEVAEPFPVEVLS-----SILGIPDKDRGRFSEWSNLVA---GVLDINFA- 191 Query: 217 PALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKA 276 +P + A E+ + + L+ ++ E A Sbjct: 192 ------IPKEVADRRSAAIEESID-YFRTLATSGNAPEGLVRRLSEVSHGGDQLSVDEIA 244 Query: 277 KTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLS 336 T L++ A Q T L R+ + + Sbjct: 245 ATCLLITVAGQETTSNTIGNMLITFSRHADQFEQVRA----------------------- 281 Query: 337 QAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMH 395 + +++ + E LR + R A ED + + I K D + + + Sbjct: 282 -----NPQFIENAVAEVLRFEPPAHEAGRIALEDCEVSGAN----ITKGDAVMVLLASGN 332 Query: 396 LDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIK 455 E TF R + +G G C G A ++ Sbjct: 333 R--EAVERGDTFSVTR------------------PDVSSLSYGRGIHHCLGSALANSMLQ 372 Query: 456 QFLILMLSYFE 466 FL + + Sbjct: 373 HFLRELSQRYR 383 >2IJ7-A nrPDB Length = 396 Score = 55.3 bits (131), Expect = 6e-08, Method: Composition-based stats. Identities = 60/369 (16%), Positives = 118/369 (31%), Gaps = 72/369 (19%) Query: 89 LCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMEN 148 LC D + T+A + + N+ + L+ + ++T Sbjct: 50 LCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPK-APG 108 Query: 149 LQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDN 208 L++ +R ++NS +TEG + + + + L + Sbjct: 109 LEQFLRD--TANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKL------ 160 Query: 209 FKQFDKVFPALVAGLP---IHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLND 265 F+ F + +P I+ R +A L + N+ + + L D Sbjct: 161 FRSLSIAFMSSADPIPAAKINWDRDIEY----MAGILENPNI----TTGLMGELSRLRKD 212 Query: 266 T-LSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQ 324 S D A + A +T +L +I+ P+ E+ + Sbjct: 213 PAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPE-------- 264 Query: 325 KVSLEGNPICLSQAELNDLPVLDSIIKESLR--LSSASLNIRTAKEDFTLHLEDGSYNIR 382 ++ + ++E LR LS A R A D ++ G +R Sbjct: 265 --------------------LIPAGVEELLRINLSFADGLPRLATAD----IQVGDVLVR 300 Query: 383 KDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGAT 442 K +++ + + + DPE +P+P + + DR ++ FG G Sbjct: 301 KGELVLVLLEGANFDPEHFPNPGSIELDR-----------------PNPTSHLAFGRGQH 343 Query: 443 ICPGRLFAI 451 CPG Sbjct: 344 FCPGSALGR 352 >5EX8-A nrPDB Length = 424 Score = 54.9 bits (130), Expect = 7e-08, Method: Composition-based stats. Identities = 48/408 (11%), Positives = 97/408 (23%), Gaps = 82/408 (20%) Query: 89 LCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMEN 148 + F + + T+A + D + + + + + Sbjct: 93 VLGSDKFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVVPAFSHRRMQKFRPRVEQI 152 Query: 149 LQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDN 208 +Q + ++ + + G RD Q Sbjct: 153 VQDSL------DTIESLGGPVDFVPHFGWAIATPATCDFLG---IPRDDQ---------- 193 Query: 209 FKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLS 268 + L+A + A K ++ Q R + + + + Sbjct: 194 ----ADLARILLASRTDRSDKRRTAAGNKFMTYMKQHVAQSRRGSGDDL-FGIVGRENGD 248 Query: 269 TFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSL 328 D E V+ A+ + M+ P E+ + E Sbjct: 249 AITDAELTGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLREKPETVPEW------- 301 Query: 329 EGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIA 388 + E++R + +T T + G+ ++ D + Sbjct: 302 ---------------------LDETMRYLTTD--EKTHPRVATQDVRIGNQLVKAGDTVT 338 Query: 389 LYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRL 448 + P F R K ++ FG G C GR Sbjct: 339 CSLLAANR-PNYPSAEDEFDITR------------------EKAEHLAFGHGIHHCLGRA 379 Query: 449 FAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIE 496 A K + + F D R + + PP D+E Sbjct: 380 MAELMFKVSIPALAHRF--------PTLRLADPQR-EITLGPPPFDVE 418 >2NZA-A nrPDB Length = 413 Score = 54.1 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 22/119 (18%), Positives = 42/119 (35%), Gaps = 25/119 (21%) Query: 350 IKESLR---LSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLT 406 + E LR ++ R A ED +H I + + + + DP+++PDP Sbjct: 281 LDELLRWISHRTSVGLARIALEDVEVH----GTRIAAGEPVYVSYLAANRDPDVFPDPDR 336 Query: 407 FKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 465 DR ++ +G+G C G + A + + + +L Sbjct: 337 IDLDR------------------DPNPHLAYGNGHHFCTGAVLARMQTELLVDTLLERL 377 >6BLD-A nrPDB Length = 419 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 42/397 (10%), Positives = 100/397 (25%), Gaps = 67/397 (16%) Query: 85 YHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTES 144 ++V G ++ + ++DP + + + +S Sbjct: 76 TNEVFLSGNGVLFENVPAELLEASQSFLAMDP---PRHTKLRKLVSAAFTPRQVRRIEDS 132 Query: 145 MMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILN 204 + N + I+ + A + + + + + R + AH + Sbjct: 133 IKINAKGIV-----DELRMAGGGVDFVEHCAKELPIRTLSDMVGIPEADR--ERVAHAAD 185 Query: 205 NLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLN 264 L ++ + + H LA + +L S + Sbjct: 186 ALVSWADPRYLNGREPLAVLFENQMYLHQVAASLAAER------RDRPGDDLFSALVNAE 239 Query: 265 DTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQ 324 D + A +++ A T L + P + + A Sbjct: 240 VDGDRLADADVAAFFVLLAVAGNDTTRQTISHGLKALTDFPSQKAWLLADFDTRIGTA-- 297 Query: 325 KVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKD 384 ++E +R ++ + R E G IR Sbjct: 298 -------------------------VEELVRWATPVMTFRRTAAA---DFELGGQLIRAG 329 Query: 385 DIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATIC 444 + + ++ + D + + P R + + C Sbjct: 330 EKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGFGGGGVHF-----------------C 372 Query: 445 PGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQ 481 G A +++ +L ++L + QA P Sbjct: 373 LGAHLARAQLRAIFGELL----VQLPDIQAGDPVYVP 405 >2UUQ-A nrPDB Length = 414 Score = 48.3 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 33/192 (17%), Positives = 58/192 (30%), Gaps = 25/192 (13%) Query: 274 EKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPI 333 E A + L A+ T +L + + + V L + + + Sbjct: 214 EPADDAISHLVAAGVGADGDTAGTLSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQR 273 Query: 334 CLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQL 393 L + +P D++ +E LRL+S ++ T + G I + L Sbjct: 274 RLLLDDPEGIP--DAV-EELLRLTSP---VQGLARTTTRDVTIGDTTIPAGRRVLLLYGS 327 Query: 394 MHLDPEIY-PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIH 452 + D Y PD R + F GA C G A Sbjct: 328 ANRDERQYGPDAAELDVTR------------------CPRNILTFSHGAHHCLGAAAARM 369 Query: 453 EIKQFLILMLSY 464 + + L +L+ Sbjct: 370 QCRVALTELLAR 381 >2YJN-B nrPDB Length = 381 Score = 39.5 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 15/65 (23%), Positives = 26/65 (40%), Gaps = 3/65 (4%) Query: 347 DSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLT 406 + E LRL A R T + G + I + + + + + DPE++ +P Sbjct: 256 QRTVAEVLRLHPALHLERRT---ATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDR 312 Query: 407 FKYDR 411 DR Sbjct: 313 LDVDR 317 >3JCU-S nrPDB Length = 295 Score = 34.8 bits (78), Expect = 0.091, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 29/89 (32%), Gaps = 10/89 (11%) Query: 402 PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILM 461 PD F D LD + + + Y Y PFG G FA ++ + + Sbjct: 80 PDRRIFLPDGLLDRD--DIPEYLNGEVPGDYGYDPFGLGKKP---EDFAKYQAFELI--- 131 Query: 462 LSYFELELIEGQAKCPPLDQSRAGLGILP 490 + ++ P ++ G P Sbjct: 132 --HARWAMLGAAGCVIPEAFNKFGANCGP 158 >5MDX-S nrPDB Length = 232 Score = 34.8 bits (78), Expect = 0.097, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 28/89 (31%), Gaps = 10/89 (11%) Query: 402 PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILM 461 PD F D LD + + Y Y PFG G FA ++ + + Sbjct: 17 PDRRIFLPDGLLD--RSEIPEYLNGEVAGDYGYDPFGLGKKP---ENFAKYQAFELI--- 68 Query: 462 LSYFELELIEGQAKCPPLDQSRAGLGILP 490 + ++ P ++ G P Sbjct: 69 --HARWAMLGAAGFIIPEALNKYGANCGP 95 >5L9W-B nrPDB Length = 732 Score = 31.8 bits (70), Expect = 0.80, Method: Composition-based stats. Identities = 17/120 (14%), Positives = 37/120 (30%) Query: 235 REKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPAT 294 R +A + L +R+ I + + D+ + +++ + + Sbjct: 121 RRNIAVQNKPLPLIERDLILGVRERIDSSGSVVRPLDEEDVRTKLRMLMDRGARAIVVSL 180 Query: 295 FWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESL 354 WS + EE K V + + E VLD+ ++ S+ Sbjct: 181 LWSFMNPAHEKRVREIIREEYKEYHIGFVPVVMSHSVVSKIGEYERTMTAVLDAYLQRSM 240 >4YXC-B nrPDB Length = 227 Score = 31.4 bits (69), Expect = 0.87, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 18/44 (40%) Query: 346 LDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIAL 389 IKE LRL+ S+ L + Y I + +++ + Sbjct: 161 TRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 204 >4YXB-D nrPDB Length = 80 Score = 31.4 bits (69), Expect = 0.87, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 18/44 (40%) Query: 346 LDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIAL 389 IKE LRL+ S+ L + Y I + +++ + Sbjct: 14 TRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 57 >1T4B-A nrPDB Length = 367 Score = 30.6 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 23/159 (14%), Positives = 55/159 (34%), Gaps = 3/159 (1%) Query: 28 QTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLS--Y 85 ++GE P++N +P G + + L+ ++ + G T K++ + L Sbjct: 209 RSGELPVDNFGVPLAGSLIPWIDKQLDNGQSREEWKGQAETNKILNTSSVIPVDGLCVRV 268 Query: 86 HKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESM 145 + CH + F K + + N + ++ L A+ + Sbjct: 269 GALRCHSQAFTIKLKKDVSIPTVEELLAAHNPWAKVVPNDREITMRELTPAAVTGTLTTP 328 Query: 146 MENLQRIMRPPVSSNSKTAAWVTE-GMYSFCYRVMFEAG 183 + L+++ P ++ T G R++ + Sbjct: 329 VGRLRKLNMGPEFLSAFTVGDQLLWGAAEPLRRMLRQLA 367 >5C8J-I nrPDB Length = 207 Score = 30.6 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 9/37 (24%), Positives = 19/37 (51%) Query: 301 MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQ 337 M +NPE M+ EE +R ++ + + + P+ + Sbjct: 71 MSKNPEMMEKLQEEQQRIMQLNAELMKMSFRPMIYTW 107 >4BWI-A nrPDB Length = 432 Score = 30.2 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 36/215 (16%), Positives = 73/215 (33%), Gaps = 23/215 (10%) Query: 213 DKVFPALVAGLPIHMFRTAHNAREKL---AESLRHENLQKRESISELISLRMFLNDTLST 269 ++ + GL + ARE+L + + + +R+ EL + Sbjct: 63 NRAALPSLLGLHFPVEDIPPQAREELGNQRKMIAVDVAHRRKKSHELSGRISPTEHSNGH 122 Query: 270 FDDLEKAKTHLVVLWASQANTIPAT-------FWSLFQMIRNPEAMKAATEEVKRTLENA 322 + ++ H+ L A + W + M + + TE+ T+ Sbjct: 123 YTTVDSC--HIQYLLAMGVLSSLTVPVMQDQQLWGI--MAVHHSKPRRFTEQEWETMALL 178 Query: 323 GQKVSLEGNPICLSQAELNDLPVLDSIIKESL--RLSSASLNIRTAKEDFTLHLEDGSYN 380 ++VSL LS+ V ++E+L RL + E + LE Sbjct: 179 SKEVSLAITQSQLSRQ------VHQQQVQEALVQRLETTVAQYGDRPETWQYALETVGQA 232 Query: 381 IRK-DDIIALYPQLMHLDPEIYPDPLTFKYDRYLD 414 + ++ + P L + Y L F + +L+ Sbjct: 233 VEADGAVLYIAPDLTGSVAQHYQWNLRFDWGNWLE 267 >4CX7-A nrPDB Length = 431 Score = 29.8 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 14/52 (26%), Positives = 24/52 (46%), Gaps = 4/52 (7%) Query: 385 DIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMP 436 D++ L Q DPE++ P D L+ + + L+LK+Y +P Sbjct: 230 DVVPLVLQANGRDPELFEIP----PDLVLEVAMEHPKYEWFRELELKWYALP 277 >5W7L-A nrPDB Length = 205 Score = 29.8 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 52/163 (31%), Gaps = 21/163 (12%) Query: 138 LNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRR-D 196 + E + ++ + S+ + A ++ + L FG+ + Sbjct: 47 FTQARPGLNEKIFKMYKFKTMSDERDANG----------ELLPDDQRLGKFGKLIRSLSL 96 Query: 197 TQKAHILNNLDNFKQFDKVFPALVAGLPI--HMFRTAHNAREKLAESLRHENLQKRESIS 254 + + N L F P LV LPI + H+ R + L N + S Sbjct: 97 DELPQLFNVLKGDMSFIGPRPLLVEYLPIYNETQKHRHDVRPGIT-GLAQVNGRNAISWE 155 Query: 255 ELISLRMFLNDTLSTFDDLEKAKTHLVVLW-------ASQANT 290 + ++ LS D++ A + + QA T Sbjct: 156 KKFEYDVYYAKNLSFMLDVKIALMTIEKVLKRSGVSKEGQATT 198 >1CJM-A nrPDB Length = 295 Score = 28.3 bits (61), Expect = 7.3, Method: Composition-based stats. Identities = 10/63 (15%), Positives = 21/63 (33%), Gaps = 6/63 (9%) Query: 352 ESLRLSSAS------LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPL 405 E+L+ + L + + Y R +A+ H + +P+P Sbjct: 94 ETLKDTPPPRLIKSHLPLALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPG 153 Query: 406 TFK 408 T+ Sbjct: 154 TWD 156 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.117 0.297 Lambda K H 0.267 0.0362 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,592,571 Number of Sequences: 36641 Number of extensions: 611765 Number of successful extensions: 2506 Number of sequences better than 10.0: 180 Number of HSP's better than 10.0 without gapping: 209 Number of HSP's successfully gapped in prelim test: 32 Number of HSP's that attempted gapping in prelim test: 1714 Number of HSP's gapped (non-prelim): 311 length of query: 504 length of database: 10,336,785 effective HSP length: 101 effective length of query: 403 effective length of database: 6,636,044 effective search space: 2674325732 effective search space used: 2674325732 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 61 (28.3 bits)