BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P22304 (550 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6IOZ-A nrPDB 1064 0.0 4UG4-A nrPDB 122 4e-28 4UPI-A nrPDB 113 2e-25 3ED4-A nrPDB 92 6e-19 1P49-A nrPDB 91 1e-18 2QZU-A nrPDB 89 4e-18 4UPH-A nrPDB 86 4e-17 6BIA-A nrPDB 80 2e-15 4UPK-A nrPDB 79 4e-15 2W8S-A nrPDB 79 6e-15 2VQR-A nrPDB 78 1e-14 4UPL-A nrPDB 68 9e-12 1FSU-A nrPDB 68 1e-11 5G2V-A nrPDB 66 5e-11 4FDJ-A nrPDB 64 1e-10 5G2T-A nrPDB 64 2e-10 4MHX-A nrPDB 60 2e-09 1E2S-P nrPDB 58 1e-08 4CXU-A nrPDB 51 1e-06 4KAV-A nrPDB 37 0.018 5FGN-A nrPDB 36 0.035 4UOP-A nrPDB 34 0.16 4UOO-A nrPDB 33 0.22 2W8D-A nrPDB 32 0.65 4ZEF-A nrPDB 32 1.0 4TN0-A nrPDB 30 2.0 3CL7-A nrPDB 30 2.2 5OLB-A nrPDB 30 2.7 5FN1-A nrPDB 30 3.5 5I5F-A nrPDB 29 4.5 5MHP-A nrPDB 29 5.3 6GRI-C nrPDB 29 5.6 2LDX-A nrPDB 28 7.1 >6IOZ-A nrPDB Length = 517 Score = 1064 bits (2752), Expect = 0.0, Method: Compositional matrix adjust. Identities = 516/517 (99%), Positives = 516/517 (99%) Query: 34 TDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLT 93 TDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAV APSRVSFLT Sbjct: 1 TDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVAAPSRVSFLT 60 Query: 94 GRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSW 153 GRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSW Sbjct: 61 GRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSW 120 Query: 154 SFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMK 213 SFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMK Sbjct: 121 SFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMK 180 Query: 214 TSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQR 273 TSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQR Sbjct: 181 TSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQR 240 Query: 274 EDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTS 333 EDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTS Sbjct: 241 EDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTS 300 Query: 334 DHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEP 393 DHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEP Sbjct: 301 DHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEP 360 Query: 394 GRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYL 453 GRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYL Sbjct: 361 GRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYL 420 Query: 454 PGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLAN 513 PGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLAN Sbjct: 421 PGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLAN 480 Query: 514 FSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP 550 FSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP Sbjct: 481 FSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP 517 >4UG4-A nrPDB Length = 515 Score = 122 bits (306), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 122/402 (30%), Positives = 177/402 (44%), Gaps = 62/402 (15%) Query: 33 TTDALNVLLIIVDDLRPSLGCYG-DKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSF 91 TT N+L+I+VD L L G + +PN+ LA S F N + +CAP+R SF Sbjct: 5 TTGKPNILIIMVDQLNGKLFPDGPADFLHAPNLKALAKRSARFHNNYTSSPLCAPARASF 64 Query: 92 LTGRRPDTTRLYDFNSYWRVHAGNFSTIPQY---FKENGYVTMSVGKVFHPGISSNH--- 145 + G+ P TR+YD + ++ S+IP Y + GY T GK+ G H Sbjct: 65 MAGQLPSRTRVYDNAAEYQ------SSIPTYAHHLRRAGYYTALSGKMHFVGPDQLHGFE 118 Query: 146 ----TDDSP--YSWSFPPYHPSSEK----YENTKTCRGPDGELHANLLCPVDVLDVPEGT 195 TD P + W+ P Y E+ Y N + G V ++ Sbjct: 119 ERLTTDIYPADFGWT-PDYRKPGERIDWWYHNLGSVTG------------AGVAEITNQM 165 Query: 196 LPDKQSTEQAIQLL-----EKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYP-LENITL 249 D + A Q L E S P+ L V + PH P+ ++F LY E++T Sbjct: 166 EYDDEVAFLANQKLYQLSRENDDESRRPWCLTVSFTHPHDPYVARRKFWDLYEDCEHLT- 224 Query: 250 APDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQ--RKIRQSYFASVSYL 307 PEV G P+ Q Q + +S Y V + R+ R++YFA++SYL Sbjct: 225 ---PEV--GAIPLD-------EQDPHSQRIMLSCDYQNFDVTEENVRRSRRAYFANISYL 272 Query: 308 DTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRT 367 D +VG L+ L ++ + T+I F SDHG LGE G W K + F+ + VPL+ PG Sbjct: 273 DEKVGELIDTLTRTRMLDDTLILFCSDHGDMLGERGLWFKMNFFEGSARVPLMIAGPGIA 332 Query: 368 ASL---PEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSL 406 L P + + P L D A +E R D V LV + Sbjct: 333 PGLHLTPTSNLDVTPTL--ADLAGISLEEVRPWTDGVSLVPM 372 >4UPI-A nrPDB Length = 576 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 123/469 (26%), Positives = 185/469 (39%), Gaps = 108/469 (23%) Query: 25 GSETQA-NST----TDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAF 78 G+ET NS+ T N+L I+ D LR L CYG + + +PNID+LA + F NA+ Sbjct: 12 GAETAVPNSSSVPMTQNRNILWIMCDQLRFDYLSCYGHERLNTPNIDKLAKRGVRFTNAY 71 Query: 79 AQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIP---------QYFKENGYV 129 Q V PSR+S TGR Y R H + IP + ++ G Sbjct: 72 VQATVAGPSRMSAYTGR------------YVRSHGSTQNGIPLRVGEPTLGDHLRDVGMR 119 Query: 130 TMSVGK------------------------VFHPGISSNHTDDSPYSWSFPPYHPSSEKY 165 + +GK V G + DD + + P+ Y Sbjct: 120 NVLIGKTHMRPDLDGMKRLGIDPDSEIGARVGEGGFDAFDRDDGVHPTGYRKKEPAYNDY 179 Query: 166 --------EN-----TKTCRGPDGELHAN-LLCPVDV-LDVPEGTLPDKQSTEQAIQLLE 210 EN + G GE + LL D VPE T +A++ +E Sbjct: 180 LRHAGFQAENPWEFWANSAEGKGGENQSGWLLTHADKPARVPEEHSETAYMTRRAMEFME 239 Query: 211 KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDI 270 + P+ + Y KPH P+ P + ++ +++ P V A +P Sbjct: 240 AAEKDGRPWCAHLSYIKPHWPYIVPAPYHDMFGPDDVK----PAVRSDEELKAAHPLFKA 295 Query: 271 RQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIA 330 E+V + N + + + K+ +Y + +D Q+G+L + + + L +T+I Sbjct: 296 -MTEEVYSRNFARD------EVREKVIPAYMGLIKQIDDQLGQLFAFMQERGLDENTMIV 348 Query: 331 FTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQL 390 FT+DHG LG+H KY ++ A VPLI Y DP D A Sbjct: 349 FTADHGDYLGDHWMGEKYLFYEAAAKVPLIIY-------------------DPSDKADAT 389 Query: 391 MEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLL 439 G S LVE++ L PT AG VP H+ EGK+LL Sbjct: 390 R--GTVSDALVEMIDLAPTFVDYAG-------GVPPMHI---LEGKSLL 426 >3ED4-A nrPDB Length = 502 Score = 92.0 bits (227), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 90/331 (27%), Positives = 141/331 (42%), Gaps = 39/331 (11%) Query: 15 LVLSSVCVALGSETQANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLL 73 L+ +VC + N+++I+ DDL L YG ++V++PNID+LA + Sbjct: 6 LIGLAVCTGNAFSPALAAEAKQPNLVIIMADDLGYGDLATYGHQIVKTPNIDRLAQEGVK 65 Query: 74 FQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFN-SYWRVHAG-NFSTIPQYFKENGYVTM 131 F + +A + +PSR LTGR P T + + S V G N TI K GY T Sbjct: 66 FTDYYAPAPLSSPSRAGLLTGRMPFRTGIRSWIPSGKDVALGRNELTIANLLKAQGYDTA 125 Query: 132 SVGKVFHPGISSNHTDD-SPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLD 190 +GK+ H + TD F ++ + T ++ P L Sbjct: 126 MMGKL-HLNAGGDRTDQPQAQDMGFDYSLANTAGFVTDATLDNAKERPRYGMVYPTGWLR 184 Query: 191 VPEGT-LPDKQSTE----QAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLE 245 + T DK S E + + L+ K S PFFL V + + H P PK++ +Y Sbjct: 185 NGQPTPRADKMSGEYVSSEVVNWLDNKKDS-KPFFLYVAFTEVHSPLASPKKYLDMY--S 241 Query: 246 NITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVS 305 A + PD + Y W D P+ + Y+A++S Sbjct: 242 QYMSAYQKQHPD----LFYGDWAD-------------KPWRGV---------GEYYANIS 275 Query: 306 YLDTQVGRLLSALDDLQLANSTIIAFTSDHG 336 YLD QVG++L + + ++TI+ FTSD+G Sbjct: 276 YLDAQVGKVLDKIKAMGEEDNTIVIFTSDNG 306 >1P49-A nrPDB Length = 562 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 106/421 (25%), Positives = 176/421 (41%), Gaps = 71/421 (16%) Query: 38 NVLLIIVDDLRPSL-GCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96 N++L++ DDL GCYG+K +R+PNID+LAS + A + PSR +F+TGR Sbjct: 7 NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLATPSRAAFMTGRY 66 Query: 97 PDTTRLYDFNS----YWRVHAGNF----STIPQYFKENGYVTMSVGKVFHPGISSNHTDD 148 P + + ++ + +G T + K+ GY T +GK +H G+S + D Sbjct: 67 PVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGK-WHLGMSCHSKTD 125 Query: 149 SPYSWSFPPYHPSSEKY----ENTKTCRGPDGELHAN-----LLCPVDVLDVPEGTLPDK 199 + P +H + Y N + C+ +G + + P+ ++ V TL Sbjct: 126 FCHH---PLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTL--- 179 Query: 200 QSTEQAIQLLEK-MKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDG 258 + + LL + S FLA + F + + + N + P D Sbjct: 180 -AALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDN 238 Query: 259 LPPVAYNPWMDIRQREDVQALNISVPYGPIPV------DFQRKIRQSYFA-SVSYLDTQV 311 L QR + + Y + DF K + + +V +D V Sbjct: 239 LTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSV 298 Query: 312 GRLLSALDDLQLANSTIIAFTSDHGWALGE-------HG------EWAKYSNFDVATHVP 358 G++L+ LD+L+LAN T+I FTSD G + E HG + K +N++ VP Sbjct: 299 GQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVP 358 Query: 359 LIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQV 418 I P + +AG+K+ D + M+ +FPT+A LAG + Sbjct: 359 GILRWP----RVIQAGQKI-------DEPTSNMD-------------IFPTVAKLAGAPL 394 Query: 419 P 419 P Sbjct: 395 P 395 >2QZU-A nrPDB Length = 491 Score = 89.4 bits (220), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 97/403 (24%), Positives = 166/403 (41%), Gaps = 51/403 (12%) Query: 24 LGSETQANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQA 82 L + QA N++ I+ D R ++GC G + V++P++D+LAS + F NA + Sbjct: 15 LSTGLQAQEKQPTPNLVFIMADQYRGDAIGCIGKEPVKTPHLDKLASEGINFTNAISSYP 74 Query: 83 VCAPSRVSFLTGRRPDTTRLY-DFNS----YWRVHAGNFSTIPQYFKENGYVTMSVGKV- 136 V +P+R +TG P +++ + NS Y + N K+ GY +GK Sbjct: 75 VSSPARGMLMTGMYPIGSKVTGNCNSETAPYGVELSQNARCWSDVLKDQGYNMGYIGKWH 134 Query: 137 ----FHPGISS--NHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLD 190 + P + + N + W P + + T ++ N P D Sbjct: 135 LDAPYKPYVDTYNNRGKVAWNEWCPPERRHGFDHWIAYGTYDYHLKPMYWNTTAPRDSFY 194 Query: 191 VPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLA 250 P+ +++ +AI+ + K PF L V + PH + L Sbjct: 195 YVNQWGPEYEAS-KAIEYINGQKDQKQPFALVVSMNPPHTGYE---------------LV 238 Query: 251 PDPEVPDGLPPVAYNPWMDIRQREDVQALNISVP----YGPIPVDFQRKIRQSYFASVSY 306 PD + +I + DV+AL P G D+ R ++Y+A ++ Sbjct: 239 PDR-------------YKEIYKDLDVEALCKGRPDIPAKGTEMGDYFRNNIRNYYACITG 285 Query: 307 LDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIF----- 361 +D VGR++ AL L ++TI+ FTSDHG +G H K ++ + +P+I Sbjct: 286 VDENVGRIIEALKQNNLFDNTIVVFTSDHGICMGAHENAGKDIFYEESMRIPMILSWPDQ 345 Query: 362 YVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELV 404 P ++ L A L+P L S+ + Q+ DL V Sbjct: 346 IKPRKSDPLMIAFADLYPTLLSMMGFSKEIPETVQTFDLSNEV 388 >4UPH-A nrPDB Length = 547 Score = 85.9 bits (211), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 97/403 (24%), Positives = 153/403 (37%), Gaps = 56/403 (13%) Query: 38 NVLLIIVDDLRP-SLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96 NVLLI D R L G V++PN+D LA +LF FA A +P+R + TG Sbjct: 46 NVLLISADQWRGDCLSAVGHASVKTPNVDALAQDGVLFTRHFAGTAPASPARATLYTG-- 103 Query: 97 PDTTRLYDFNSYWRVHA----GNFSTIPQYFKENGYVTMSVGKVFHP----GISSNHTDD 148 LY N + F + + GY G G+ N Sbjct: 104 -----LYQMNHRVCRNGSPLDARFDNLALAARRGGYDPTLFGYTDTAPDPRGMDPNDPHL 158 Query: 149 SPYSWSFPPYH-----PSSEK-YENTKTCRGPDGELHANLLCPV-----DVLDV-PEGTL 196 + Y P + P EK + + RG ++ PV ++ DV P + Sbjct: 159 TTYEGVLPGFSARQLLPEHEKQWLSWLRSRGHPEATSRDIHIPVGATPGEISDVAPAYSK 218 Query: 197 PDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLEN---ITLAPDP 253 + Q+ A + + + +P+F V + +PH PF P+ + +++ + A + Sbjct: 219 DETQTAFLAGEFIRWLGEQDAPWFAHVSFLRPHPPFSVPEPYNRMFTPSDGPAFARAANR 278 Query: 254 EVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGR 313 E + P+ I + + S + IR Y+ ++ +DTQ+GR Sbjct: 279 EAEQAVHPLLAFALPLIGKDSFIYGGEGSA--SDWTSEDLSAIRAIYYGMIAEVDTQLGR 336 Query: 314 LLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEA 373 + AL ++ + T+I FTSDH +G+H K FD + HVPL+ PG Sbjct: 337 IWQALKNVGAWDDTLIIFTSDHAEMMGDHWMLGKGGFFDGSYHVPLVIRDPGHPGGA--- 393 Query: 374 GEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGL 416 GRQ +FPTL GL Sbjct: 394 --------------------GRQVERFTSAADIFPTLCDRLGL 416 >6BIA-A nrPDB Length = 477 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 91/399 (22%), Positives = 151/399 (37%), Gaps = 91/399 (22%) Query: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96 N++LI+ DDL +G G K + +PNID LA F +A+ C PSR + +TGR Sbjct: 28 NIILIVADDLGYADVGFNGSKDIITPNIDDLAKSGTSFSDAYVAHPFCGPSRAALMTGRY 87 Query: 97 PDTTRLYDFNSYWRVHAGNFST----IPQYFKENGYVTMSVGKVFHPGISSNHTD----- 147 P FN R T I + EN Y T ++GK +H G + H Sbjct: 88 PHKIG-SQFNLPTRGSNVGVPTDAKFISKLLNENNYFTGALGK-WHMGDTPQHHPNKRGF 145 Query: 148 DSPYSWSFPPYHPSSEKYENTKTCRGPDGELHA-NLLCPVD--VLDVPEGTLPDKQSTEQ 204 D Y + ++ ++Y+ + G + + P++ +V E + + Sbjct: 146 DEYYGFLGGGHNYFPDQYQPQYKKQKAQGLKNIFEYITPLEHNGKEVKETQYITDALSRE 205 Query: 205 AIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAY 264 A+ ++K PFFL + Y+ PH P + E ++P Sbjct: 206 AVNFVDKAVNKKHPFFLYLAYNAPHTPLQAKDEDMAMFP--------------------- 244 Query: 265 NPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLA 324 + + K R++Y V +D VG+L+ AL Sbjct: 245 --------------------------NIKNKDRKTYAGMVYAVDRGVGKLVEALKKNNQY 278 Query: 325 NSTIIAFTSDHGWALGEHG-----EWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFP 379 ++T+I F SD+G L + + K S + VP++F+ P + Sbjct: 279 DNTLIVFMSDNGGKLSKGANNFPLKAGKGSTQEGGFRVPMLFHWPKHVPA---------- 328 Query: 380 YLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQV 418 G++ V + L+PT A LAG +V Sbjct: 329 --------------GKRFSHPVSALDLYPTFAALAGAKV 353 >4UPK-A nrPDB Length = 538 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 99/433 (22%), Positives = 164/433 (37%), Gaps = 53/433 (12%) Query: 38 NVLLIIVDDLRPSL--GCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGR 95 NVL II+D LR G D V P++ LA ++ F+ ++ C PSR S LTG+ Sbjct: 35 NVLFIIIDQLRADCLWGALADH-VELPHLRALAQDAVSFRRHYSVTNPCGPSRASILTGQ 93 Query: 96 RPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVG--KVFHPGISSNHTDDSPYSW 153 R + R N +T ++ GY+ + G + + D + ++ Sbjct: 94 YAMNHRSVRNGTPLRHDTPNIAT---EMRKAGYLPLLFGYTDTSQDPRAYDANDPALKTY 150 Query: 154 SFP--PYHPSSEK-------YENTKTCRGPDGELHANLLCPV-DVLDVPEGTLP------ 197 FP +H +E +++ RG + +A + P D P P Sbjct: 151 EFPMRGFHEVTEMRLEMSYPWQSHLKNRGYAFDDYAQVYVPRPDADGTPRLNGPAMYRAE 210 Query: 198 DKQSTEQAIQLLEKMKTSASP-FFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVP 256 D + Q L M A +F + Y +PH P P + +Y + L +P Sbjct: 211 DSDTAFLTDQFLANMPAWAGQNWFAHLTYIRPHPPLVAPAPYNTMYDPAKLPLPA--RLP 268 Query: 257 DGLPPVAYNPWMDIRQREDVQA-LNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLL 315 A +P+ R A + P + + +R Y + +DT +GR++ Sbjct: 269 GRDDETAEHPFFGPATRYSSPASFVLGFPDLEPTDETIQTLRAVYLGLATEVDTHIGRVI 328 Query: 316 SALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGE 375 + L + + T+I T+DHG LG+ W K + +D A H PLI PG Sbjct: 329 AHLKETGQYDDTLIVVTADHGEMLGDRHSWGKMTVYDAAYHTPLIIRAPG---------- 378 Query: 376 KLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREG 435 +PG E + L PT+ G ++P S L E Sbjct: 379 ---------------CKPGHVVEAPTESIDLMPTILDWVGQEIPNAVDGRSLRPFLTGEA 423 Query: 436 KNLLKHFRFRDLE 448 + + + F +L+ Sbjct: 424 PSDWRQYSFSELD 436 >2W8S-A nrPDB Length = 543 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 113/467 (24%), Positives = 180/467 (38%), Gaps = 97/467 (20%) Query: 32 STTDALNVLLIIVDDLRPS-----LGCYGDK-LVRSPNIDQLASHSLLFQNAFAQQAVCA 85 S+ NVLLI+VD R + G + +++PN+D+L L F+N Sbjct: 28 SSMTRKNVLLIVVDQWRADFIPHLMRAEGREPFLKTPNLDRLCREGLTFRNHVTTCVPGG 87 Query: 86 PSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIP---------QYFKENGYVTMSVGKV 136 P+R S LTG LY N H +T+P + + GY +G Sbjct: 88 PARASLLTG-------LYLMN-----HRAVQNTVPLDQRHLNLGKALRAIGYDPALIGYT 135 Query: 137 FHPGISSNHTDDSPYSW----------SFPPYHPSSEKY------------ENTKTCRGP 174 + P S + P+ E Y EN + P Sbjct: 136 TTTPDPRTTSARDPRFTVLGDIMDGFRSVGAFEPNMEGYFGWVAQNGFELPENREDIWLP 195 Query: 175 DGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRY 234 +GE H+ +P+ TE+A+ L+ PFFL +GY++PH PF Sbjct: 196 EGE-HSVPGATDKPSRIPKEFSDSTFFTERALTYLKG--RDGKPFFLHLGYYRPHPPFVA 252 Query: 235 PKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMD-----IRQR---EDVQALNISVPYG 286 + +Y E++ E PD A +P M IR+ + ++ G Sbjct: 253 SAPYHAMYKAEDMPAPIRAENPDA--EAAQHPLMKHYIDHIRRGSFFHGAEGSGATLDEG 310 Query: 287 PIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWA 346 I R++R +Y ++ +D +GR+ + LD+ + T+I FTSDHG LG+H Sbjct: 311 EI-----RQMRATYCGLITEIDDCLGRVFAYLDETGQWDDTLIIFTSDHGEQLGDHHLLG 365 Query: 347 KYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSL 406 K + +PL+ + +AG+ A Q+ E +S+D++ Sbjct: 366 KIGYNAESFRIPLV---------IKDAGQNR--------HAGQIEEGFSESIDVM----- 403 Query: 407 FPTLAGLAGLQVPPRCPVPSFHVELCREGK------NLLKHFRFRDL 447 PT+ G + P C S + EGK L F FRD+ Sbjct: 404 -PTILEWLGGETPRACDGRSL-LPFLAEGKPSDWRTELHYEFDFRDV 448 >2VQR-A nrPDB Length = 543 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 104/433 (24%), Positives = 168/433 (38%), Gaps = 84/433 (19%) Query: 32 STTDALNVLLIIVDDLRPS-----LGCYGD-KLVRSPNIDQLASHSLLFQNAFAQQAVCA 85 S+ NVLLI+VD R L G +++PN+D+L + F+N Sbjct: 28 SSMRKKNVLLIVVDQWRADFVPHVLRADGKIDFLKTPNLDRLCREGVTFRNHVTTCVPAG 87 Query: 86 PSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIP--QYFKENGYVTMSVGKVFHPGISS 143 P+R S LTG LY N H +T+P Q G VG + P + Sbjct: 88 PARASLLTG-------LYLMN-----HRAVQNTVPLDQRHLNLGKALRGVG--YDPALI- 132 Query: 144 NHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANL-----LCPVDVLDVPEGT--- 195 +T P + P P + P G N+ + D+PE Sbjct: 133 GYTTTVPDPRTTSPNDPRFRVLGDLMDGFHPVGAFEPNMEGYFGWVAQNGFDLPEHRPDI 192 Query: 196 -LPDKQS----------------------TEQAIQLLEKMKTSASPFFLAVGYHKPHIPF 232 LP+ + TE+A+ L+ PFFL +GY++PH PF Sbjct: 193 WLPEGEDAVAGATDRPSRIPKEFSDSTFFTERALTYLKG--RDGKPFFLHLGYYRPHPPF 250 Query: 233 RYPKEFQKLYPLENI---TLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIP 289 + +Y E++ A +P++ P+ IR+ Q S + Sbjct: 251 VASAPYHAMYRPEDMPAPIRAANPDIEAAQHPLMKFYVDSIRRGSFFQGAEGSG--ATLD 308 Query: 290 VDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYS 349 R++R +Y ++ +D +GR+ S LD+ + T+I FTSDHG LG+H K Sbjct: 309 EAELRQMRATYCGLITEVDDCLGRVFSYLDETGQWDDTLIIFTSDHGEQLGDHHLLGKIG 368 Query: 350 NFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPT 409 D + +PL+ + +AGE ++ + +E G E + + PT Sbjct: 369 YNDPSFRIPLV---------IKDAGE---------NARAGAIESG-----FTESIDVMPT 405 Query: 410 LAGLAGLQVPPRC 422 + G ++P C Sbjct: 406 ILDWLGGKIPHAC 418 >4UPL-A nrPDB Length = 569 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 58/215 (26%), Positives = 93/215 (43%), Gaps = 21/215 (9%) Query: 202 TEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENI--TLAPDPEVPDGL 259 T +A++ +E+ P+ + Y KPH P+ P+ + ++ E++ + D E + Sbjct: 225 TSRAMEFIEQ---QTGPWCCHLSYIKPHWPYIVPEPYASMFGPEHVQDVVRSDSERQNAH 281 Query: 260 PPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALD 319 P + +MD + E + P +Y + D Q+GRL L+ Sbjct: 282 P--LFKAFMDTKVGEAFSRQEVRDAVIP-----------AYMGLIKQADDQMGRLFKWLE 328 Query: 320 DLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFP 379 D T+I TSDHG LG+H K D +T VPLI Y P R + G Sbjct: 329 DTGRMQDTMIVLTSDHGDFLGDHWMGEKTFFHDASTRVPLIIYDP-RPEADATRGSVCDA 387 Query: 380 YLDPFDSASQLMEP--GRQSMDLVELVSLFPTLAG 412 ++ D A +E G+ +M ++E SL P L G Sbjct: 388 LVESIDLAPTFVEAAGGKPAMHILEGESLIPILHG 422 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 45/172 (26%), Positives = 73/172 (42%), Gaps = 27/172 (15%) Query: 29 QANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPS 87 + + T +N+L I+ D LR L CYG K + +P+ID+LA+ + F A+ Q +C S Sbjct: 10 EKGAETAVMNILFIMFDQLRWDYLSCYGHKTLNTPHIDRLAAKGVRFDRAYIQSPICGSS 69 Query: 88 RVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTD 147 R+S TGR Y H +++ IP E M++G Sbjct: 70 RMSTYTGR------------YVHSHGASWNGIPLKVGE-----MTMGDHLRAAGMG---- 108 Query: 148 DSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLL-CPVDVLDVPEGTLPD 198 W H +++ + PD + A + C DV + +G LP+ Sbjct: 109 ----CWLVGKTHMRADEEGMARLGLEPDSLIGARVAECGFDVFERDDGMLPE 156 >1FSU-A nrPDB Length = 492 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 98/406 (24%), Positives = 155/406 (38%), Gaps = 89/406 (21%) Query: 38 NVLLIIVDDLRPS-LGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96 +++ ++ DDL + +G +G + +R+P++D LA+ +L N + Q + PSR LTGR Sbjct: 5 HLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLLDNYYTQ-PLATPSRSQLLTGRY 62 Query: 97 PDTTRLYDFNSYWRVHAG----NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS 152 T L W + +PQ KE GY T VGK +H G+ + Sbjct: 63 QIRTGL-QHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGK-WHLGMYRKECLPTRRG 120 Query: 153 W-SFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQS------TEQA 205 + ++ Y SE Y + + C D L+ C +D D E K T++A Sbjct: 121 FDTYFGYLLGSEDYYSHERCTLIDA-LNVT-RCALDFRDGEEVATGYKNMYSTNIFTKRA 178 Query: 206 IQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYN 265 I L+ P FL + H P + P+E+ K Sbjct: 179 IALITN-HPPEKPLFLYLALQSVHEPLQVPEEYLK------------------------- 212 Query: 266 PWMDIRQREDVQALNISVPYGPIPVDF-QRKIRQSYFASVSYLDTQVGRLLSALDDLQLA 324 P DF Q K R Y VS +D VG + +AL L Sbjct: 213 -----------------------PYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLW 249 Query: 325 NSTIIAFTSDH-GWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDP 383 N+T+ F++D+ G L W + GR SL E G + ++ Sbjct: 250 NNTVFIFSTDNGGQTLAGGNNWP----------------LRGRKWSLWEGGVRGVGFV-- 291 Query: 384 FDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHV 429 ++ L + G ++ +L+ + PTL LA P+ F V Sbjct: 292 --ASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDV 335 >5G2V-A nrPDB Length = 534 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 66/265 (24%), Positives = 109/265 (41%), Gaps = 68/265 (25%) Query: 288 IPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAK 347 I +Q+ +R Y A+V +D +GRLL+ L+ + ++TII +TSD G+ LGEHG + K Sbjct: 304 ISWKYQQYMR-DYLATVLAVDENIGRLLNYLEKIGELDNTIIVYTSDQGFFLGEHGWFDK 362 Query: 348 YSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLF 407 ++ +PLI P + ++ G S + V Sbjct: 363 RFMYEECQRMPLIIRYP------------------------KAIKAGSTSSAISMNVDFA 398 Query: 408 PTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYP 467 PT AG++VP S L EGK P + R+ Y Y Sbjct: 399 PTFLDFAGVEVPSDIQGASLKPVLENEGKT----------------PADWRKAAYYHYYE 442 Query: 468 RPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDS 527 P++ S+K Y IRT D++ + ++DI E+Y + + Sbjct: 443 YPAE--------HSVK----RHYGIRTQDFK-----------LIHFYNDIDEWEMYDMKA 479 Query: 528 DPLQDHNMYNDSQ----GGDLFQLL 548 DP + +N++ ++ +L QLL Sbjct: 480 DPREMNNIFGKAEYAKKQKELMQLL 504 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 31/99 (31%), Positives = 53/99 (53%), Gaps = 4/99 (4%) Query: 38 NVLLIIVDD-LRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96 N++ ++ DD ++ CYG L+++PN+D++A+ + F N +A A+ PSR LTG+ Sbjct: 30 NIIFMMTDDHTTQAMSCYGGNLIQTPNMDRIANEGIRFDNCYAVNALSGPSRACILTGKF 89 Query: 97 PDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGK 135 D S G+ T P+ ++ GY T +GK Sbjct: 90 SHENGFTDNAS---TFNGDQQTFPKLLQQAGYQTAMIGK 125 >4FDJ-A nrPDB Length = 502 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 39/113 (34%), Positives = 60/113 (53%), Gaps = 19/113 (16%) Query: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96 N+LL+++DD+ LG YG+ +PN+D++A+ LLF N ++ + +PSR + LTGR Sbjct: 6 NILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLXSPSRAALLTGRL 65 Query: 97 PDTTRLYDFNSYWRVHAGNFST--------------IPQYFKENGYVTMSVGK 135 P Y N+ HA N T +P+ K+ GYV+ VGK Sbjct: 66 PIRNGFYTTNA----HARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGK 114 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 60/123 (48%), Gaps = 10/123 (8%) Query: 297 RQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWAL-------GEHGEW--AK 347 R Y +V +D +G++L L DL +A++T + FTSD+G AL G +G + K Sbjct: 225 RGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGK 284 Query: 348 YSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLF 407 + F+ P + + PG + + +L +D F ++ L S ++ ++L Sbjct: 285 QTTFEGGMREPALAWWPGHVTA-GQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLL 343 Query: 408 PTL 410 PTL Sbjct: 344 PTL 346 >5G2T-A nrPDB Length = 489 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 94/403 (23%), Positives = 145/403 (35%), Gaps = 93/403 (23%) Query: 38 NVLLIIVDDL-RPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96 N L+I D L + +G YG + ID++AS ++F NA+ + PSR + +G Sbjct: 25 NFLIIQCDHLTQRVVGAYGQTQGCTLPIDEVASRGVIFSNAYVGCPLSQPSRAALWSGMM 84 Query: 97 PDTTRLYDFNSYWRVHA---GNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSW 153 P T + NS V+ N T+ F E+GY + GK G P + Sbjct: 85 PHQTNVRS-NSSEPVNTRLPENVPTLGSLFSESGYEAVHFGKTHDMGSLRGFKHKEPVAK 143 Query: 154 SF--PPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEK 211 F P + +++ + + TC E A+ L Sbjct: 144 PFTDPEFPVNNDSFLDVGTC-------------------------------EDAVAYLS- 171 Query: 212 MKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIR 271 PF + PH + E ++ I+ P PE+PD Sbjct: 172 -NPPKEPFICIADFQNPHNICGFIGENAGVHTDRPIS-GPLPELPDNF------------ 217 Query: 272 QREDVQAL-NISVPYGPIPVDFQRKIRQSYFASVSY-------------LDTQVGRLLSA 317 DV+ NI P I +R + +++ +Y + QV +L A Sbjct: 218 ---DVEDWSNIPTPVQYICCSHRRMTQAAHWNEENYRHYIAAFQHYTKMVSKQVDSVLKA 274 Query: 318 LDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNF-DVATHVPLIFYVPGRTASLPEAGEK 376 L +TI+ +DHG + H K+ +F D T+VP IF PG Sbjct: 275 LYSTPAGRNTIVVIMADHGDGMASHRMVTKHISFYDEMTNVPFIFAGPG----------- 323 Query: 377 LFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVP 419 + P D L +P + L PTL LAG+ VP Sbjct: 324 IKQQKKPVDHL--LTQP---------TLDLLPTLCDLAGIAVP 355 >4MHX-A nrPDB Length = 510 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 79/306 (25%), Positives = 119/306 (38%), Gaps = 61/306 (19%) Query: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97 N LL++ DD G Y + + +P++D LA SLLF+NAF + +PSR S LTG Sbjct: 24 NALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSSSPSRASLLTGLPQ 83 Query: 98 DTTRLY-------DFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSP 150 +Y FNS+ +V ++P + G T +GK H G + + D Sbjct: 84 HQNGMYGLHQDVHHFNSFDKVR-----SLPLLLSQAGVRTGIIGKK-HVGPETVYPFDFA 137 Query: 151 YSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLE 210 Y+ EN VL V K + +Q + Sbjct: 138 YT------------EENGS------------------VLQVGRNITRIKLLVRKFLQTQD 167 Query: 211 KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDI 270 PFFL V +H PH ++ + +PD P AY+P Sbjct: 168 D-----RPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPD-WTPQAYDP---- 217 Query: 271 RQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIA 330 L++ VPY R + + +V +D VG +L L D + N T++ Sbjct: 218 --------LDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVI 269 Query: 331 FTSDHG 336 FTSD+G Sbjct: 270 FTSDNG 275 >1E2S-P nrPDB Length = 489 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 37/109 (33%), Positives = 53/109 (48%), Gaps = 5/109 (4%) Query: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96 N++LI DDL LGCYG +PN+DQLA+ L F + + ++ PSR + LTGR Sbjct: 4 NIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLATPSRAALLTGRL 63 Query: 97 PDTTRLYDFNSYWRVHAG---NFSTIPQYFKENGYVTMSVGKVFHPGIS 142 P +Y G T+ + GY+T GK +H G+ Sbjct: 64 PVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK-WHLGVG 111 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 33/135 (24%) Query: 293 QRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG---WALGEHG-----E 344 +R R + S+ LD VG L++A+ DL L T++ FT+D+G + G Sbjct: 222 ERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 281 Query: 345 WAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELV 404 K + ++ P + + PG A PG + +L + Sbjct: 282 CGKGTTYEGGVREPALAFWPGHIA------------------------PG-VTHELASSL 316 Query: 405 SLFPTLAGLAGLQVP 419 L PTLA LAG +P Sbjct: 317 DLLPTLAALAGAPLP 331 >4CXU-A nrPDB Length = 536 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 79/341 (23%), Positives = 132/341 (38%), Gaps = 69/341 (20%) Query: 38 NVLLIIVDDLRPS-LGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGR- 95 N L+I+ DDL S +G +G ++ +PN+D LA L + F + +P+R LTG Sbjct: 6 NFLVIVADDLGFSDIGTFGGEIA-TPNLDALAIAGLRLTD-FHTASAASPTRSMLLTGTD 63 Query: 96 ----------RPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNH 145 T L Y +P+ +E GY T+ GK +H G+ Sbjct: 64 HHIAGIGTMAEALTPELEGKPGYEGHLNERVVALPELLREAGYQTLMAGK-WHLGLKPEQ 122 Query: 146 TDDSPYSWSF-----------------PPYHPSSEKYENTKTCRGPDGELHANLLCPVDV 188 T P++ F PPY S+ + + E + + L Sbjct: 123 T---PHARGFERSFALLPGAANHYGFEPPYDESTPRILKGTPALYVEDERYLDTL----- 174 Query: 189 LDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLY------ 242 PEG ++ +Q L K + + PFF + + PH P + P+E + Y Sbjct: 175 ---PEGFYSSDAFGDKLLQYL-KERDQSRPFFAYLPFSAPHWPLQAPREIVEKYRGRYDA 230 Query: 243 ---PLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQR----K 295 L LA E+ V +P + + + + +AL D +R + Sbjct: 231 GPEALRQERLARLKELGLVEADVEAHPVLALTR--EWEALE----------DEERAKSAR 278 Query: 296 IRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG 336 + Y A V +D +GR++ L ++T + F SD+G Sbjct: 279 AMEVYAAMVERMDWNIGRVVDYLRRQGELDNTFVLFMSDNG 319 >4KAV-A nrPDB Length = 335 Score = 37.4 bits (85), Expect = 0.018, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 41/72 (56%), Gaps = 11/72 (15%) Query: 298 QSYFASVSYLDT---QVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVA 354 +Y +V Y+D +V R L DDL+ +++ + SDHG +LGE+G + + + +A Sbjct: 208 NTYDNTVLYVDQFIDKVIRKLENRDDLE----SVVHYVSDHGESLGENGMYLHAAPYAIA 263 Query: 355 ----THVPLIFY 362 TH+P++ + Sbjct: 264 PSGQTHIPMVMW 275 >5FGN-A nrPDB Length = 550 Score = 36.2 bits (82), Expect = 0.035, Method: Compositional matrix adjust. Identities = 20/72 (27%), Positives = 42/72 (58%), Gaps = 11/72 (15%) Query: 298 QSYFASVSYLDTQVGRLLSAL---DDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVA 354 +Y +V Y+D + +++ L DDL+ +++ + SDHG +LGE+G + + + +A Sbjct: 417 NTYDNTVLYVDQFIDKVIRKLENRDDLE----SVVHYVSDHGESLGENGMYLHAAPYAIA 472 Query: 355 ----THVPLIFY 362 TH+P++ + Sbjct: 473 PSGQTHIPMVMW 484 >4UOP-A nrPDB Length = 442 Score = 34.3 bits (77), Expect = 0.16, Method: Compositional matrix adjust. Identities = 14/48 (29%), Positives = 25/48 (52%) Query: 288 IPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDH 335 +P D + +YF +V Y D Q+G + L D + + +++ F DH Sbjct: 238 LPSDLKDTELGNYFEAVHYADKQLGEFIQKLKDSGIWDDSVVVFYGDH 285 >4UOO-A nrPDB Length = 459 Score = 33.5 bits (75), Expect = 0.22, Method: Compositional matrix adjust. Identities = 23/83 (27%), Positives = 39/83 (46%), Gaps = 10/83 (12%) Query: 299 SYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWA-------KYSNF 351 +YF + YLD V + L L ++++I DH + + ++ E A Y+ F Sbjct: 252 TYFQTARYLDESVKSFVDYLKKSGLYDNSVIIMYGDH-YGISDNHEEAMTKILGKDYNTF 310 Query: 352 D--VATHVPLIFYVPGRTASLPE 372 + A VPL+ +VPG + E Sbjct: 311 ENAQAQRVPLMIHVPGVQGGVQE 333 >2W8D-A nrPDB Length = 436 Score = 32.0 bits (71), Expect = 0.65, Method: Compositional matrix adjust. Identities = 28/111 (25%), Positives = 46/111 (41%), Gaps = 17/111 (15%) Query: 291 DFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWA---- 346 DF + +YF S YLD + + + L L + +II DH + + E+ A Sbjct: 215 DFGDSVVDNYFQSAHYLDQSIEQFFNDLKKDGLYDKSIIVMYGDH-YGISENHNKAMAKV 273 Query: 347 ----KYSNFDVA--THVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLM 391 + +++D A VPL + G GEK+ Y D A ++ Sbjct: 274 LGKDEITDYDNAQLQRVPLFIHAAGV------KGEKVHKYAGDVDVAPTIL 318 >4ZEF-A nrPDB Length = 251 Score = 31.6 bits (70), Expect = 1.0, Method: Compositional matrix adjust. Identities = 16/59 (27%), Positives = 29/59 (49%), Gaps = 8/59 (13%) Query: 270 IRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDT--------QVGRLLSALDD 320 I+ +D++ + V G DF K ++ Y S+ YLDT ++G + + +DD Sbjct: 127 IKSYDDLKGKKVGVKIGTESADFLEKNKKKYDYSIKYLDTTDALYSALEIGEVDAMMDD 185 >4TN0-A nrPDB Length = 325 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 19/69 (27%), Positives = 37/69 (53%), Gaps = 5/69 (7%) Query: 298 QSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVA--- 354 +Y ++ Y D + ++ L + + S++ + SDHG +LGE+G + + +A Sbjct: 191 NTYDNTLLYTDYLLSEIIKLLKEQKSYESSLF-YLSDHGESLGENGIYLHGMPYAIAPSY 249 Query: 355 -THVPLIFY 362 TH+P IF+ Sbjct: 250 QTHIPAIFW 258 >3CL7-A nrPDB Length = 308 Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 25/47 (53%), Gaps = 1/47 (2%) Query: 471 DIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNP-DEFLANFSD 516 D+P W + P+ K ++ Y++ T D R+T GFN D+F D Sbjct: 192 DLPYWEPNNPTGKPHLVIPYTLDTNDMRFTQVQGFNKGDDFFEYLKD 238 >5OLB-A nrPDB Length = 844 Score = 30.0 bits (66), Expect = 2.7, Method: Compositional matrix adjust. Identities = 23/81 (28%), Positives = 33/81 (40%), Gaps = 10/81 (12%) Query: 285 YGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGE 344 YGP + +R+ +D VG+L+ L L+L + F DHG Sbjct: 286 YGPFGPEMTNPLRE--------IDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDR 337 Query: 345 WAKYSNFDVATHVPLIFYVPG 365 SN+ T+V I VPG Sbjct: 338 TEFLSNY--LTNVDDITLVPG 356 >5FN1-A nrPDB Length = 237 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 13/38 (34%), Positives = 22/38 (57%) Query: 55 GDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFL 92 D L+R PN +LA+HS+ A A+Q + + ++ L Sbjct: 177 ADGLIRQPNEKELAAHSVAKYGALARQKISTGNYITTL 214 >5I5F-A nrPDB Length = 586 Score = 29.3 bits (64), Expect = 4.5, Method: Compositional matrix adjust. Identities = 24/100 (24%), Positives = 47/100 (47%), Gaps = 8/100 (8%) Query: 293 QRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFD 352 Q+ + Y ++ S +D Q+ R+L+AL + ++T++ T+ G L +S Sbjct: 409 QKNFVKRYASAASDVDAQINRVLNALREAGKFDNTVVIITAGRGIPLTPEENRFDWSQGH 468 Query: 353 VATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLME 392 + VPL+ + PG A +++ D D + LM+ Sbjct: 469 L--QVPLVIHWPGTPA------QRINVLTDHTDVMTTLMQ 500 >5MHP-A nrPDB Length = 871 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 23/81 (28%), Positives = 33/81 (40%), Gaps = 10/81 (12%) Query: 285 YGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGE 344 YGP + +R+ +D VG+L+ L L+L + F DHG Sbjct: 318 YGPFGPEMTNPLRE--------IDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDR 369 Query: 345 WAKYSNFDVATHVPLIFYVPG 365 SN+ T+V I VPG Sbjct: 370 TEFLSNY--LTNVDDITLVPG 388 >6GRI-C nrPDB Length = 272 Score = 28.9 bits (63), Expect = 5.6, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 23/44 (52%), Gaps = 6/44 (13%) Query: 361 FYVPGRTASLPEAGEKLF------PYLDPFDSASQLMEPGRQSM 398 F+V G ASLPE E+ F +L+ F++ L PG S+ Sbjct: 26 FHVRGNFASLPEFAERTFVSAVPLAHLEKFENKEVLFRPGFSSV 69 >2LDX-A nrPDB Length = 331 Score = 28.5 bits (62), Expect = 7.1, Method: Compositional matrix adjust. Identities = 10/13 (76%), Positives = 11/13 (84%) Query: 332 TSDHGWALGEHGE 344 TS HGW LGEHG+ Sbjct: 182 TSCHGWVLGEHGD 194 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6IOZ-A nrPDB 702 0.0 5G2V-A nrPDB 352 2e-97 4UPH-A nrPDB 329 2e-90 4UPK-A nrPDB 324 8e-89 2W8S-A nrPDB 321 4e-88 4UPI-A nrPDB 319 3e-87 2VQR-A nrPDB 314 6e-86 2QZU-A nrPDB 309 2e-84 4UPL-A nrPDB 291 5e-79 1P49-A nrPDB 291 5e-79 3ED4-A nrPDB 284 6e-77 4UG4-A nrPDB 284 8e-77 6BIA-A nrPDB 272 4e-73 5G2T-A nrPDB 269 2e-72 1FSU-A nrPDB 249 2e-66 4CXU-A nrPDB 220 1e-57 4MHX-A nrPDB 211 6e-55 4FDJ-A nrPDB 196 2e-50 1E2S-P nrPDB 176 3e-44 Sequences not found previously or not previously below threshold: 3LXQ-A nrPDB 88 7e-18 5I5H-A nrPDB 65 9e-11 5I5F-A nrPDB 63 2e-10 4UOP-A nrPDB 62 6e-10 4UOO-A nrPDB 54 2e-07 5XWI-A nrPDB 50 3e-06 6BNF-A nrPDB 48 1e-05 5FGN-A nrPDB 48 1e-05 4KAV-A nrPDB 48 1e-05 1O99-A nrPDB 45 1e-04 2W8D-A nrPDB 43 3e-04 4TN0-A nrPDB 43 4e-04 5UDY-A nrPDB 42 6e-04 3E2D-A nrPDB 41 0.002 5KGM-A nrPDB 40 0.002 2W5S-A nrPDB 40 0.002 5MX9-A nrPDB 40 0.004 4LR2-A nrPDB 39 0.006 5JTL-E nrPDB 39 0.007 5VEN-A nrPDB 38 0.012 4QAX-A nrPDB 38 0.014 5YLE-A nrPDB 38 0.015 5VPU-A nrPDB 37 0.019 5VEM-A nrPDB 37 0.020 4B56-A nrPDB 35 0.092 2W5W-A nrPDB 35 0.12 1T0O-A nrPDB 33 0.40 3CL7-A nrPDB 33 0.47 3IGZ-B nrPDB 32 0.61 3WBH-A nrPDB 32 0.85 5NMX-A nrPDB 31 0.92 5FL8-q nrPDB 31 0.95 5OLB-A nrPDB 31 1.1 5MHP-A nrPDB 31 1.8 2MLZ-B nrPDB 31 1.9 3WDG-A nrPDB 30 2.2 4LJ8-A nrPDB 30 2.3 1QVR-A nrPDB 30 2.3 1Z7A-A nrPDB 29 5.2 3UER-A nrPDB 28 8.6 >6IOZ-A nrPDB Length = 517 Score = 702 bits (1812), Expect = 0.0, Method: Composition-based stats. Identities = 516/517 (99%), Positives = 516/517 (99%) Query: 34 TDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLT 93 TDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAV APSRVSFLT Sbjct: 1 TDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVAAPSRVSFLT 60 Query: 94 GRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSW 153 GRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSW Sbjct: 61 GRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSW 120 Query: 154 SFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMK 213 SFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMK Sbjct: 121 SFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMK 180 Query: 214 TSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQR 273 TSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQR Sbjct: 181 TSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQR 240 Query: 274 EDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTS 333 EDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTS Sbjct: 241 EDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTS 300 Query: 334 DHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEP 393 DHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEP Sbjct: 301 DHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEP 360 Query: 394 GRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYL 453 GRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYL Sbjct: 361 GRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYL 420 Query: 454 PGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLAN 513 PGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLAN Sbjct: 421 PGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLAN 480 Query: 514 FSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP 550 FSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP Sbjct: 481 FSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP 517 >5G2V-A nrPDB Length = 534 Score = 352 bits (902), Expect = 2e-97, Method: Composition-based stats. Identities = 116/568 (20%), Positives = 200/568 (35%), Gaps = 138/568 (24%) Query: 32 STTDALNVLLIIVDD-LRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVS 90 T N++ ++ DD ++ CYG L+++PN+D++A+ + F N +A A+ PSR Sbjct: 24 EETKRPNIIFMMTDDHTTQAMSCYGGNLIQTPNMDRIANEGIRFDNCYAVNALSGPSRAC 83 Query: 91 FLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSP 150 LTG+ D S G+ T P+ ++ GY T +GK +H Sbjct: 84 ILTGKFSHENGFTDNAS---TFNGDQQTFPKLLQQAGYQTAMIGK-WHLISEPQ------ 133 Query: 151 YSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLE 210 + + + + + G+ + + D + E T++AI LE Sbjct: 134 ----------GFDHW-SILSGQHEQGD-YYDPDFWEDGKHIVEKGYATDIITDKAINFLE 181 Query: 211 KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPD------------PEVPDG 258 + PF + PH + ++ + E Sbjct: 182 N-RDKNKPFCMMYHQKAPHRNWMPAPRHLGIFNNTIFPEPANLFDDYEGRGKAAREQDMS 240 Query: 259 LPPVAYNPWM----------------------------------DIRQREDVQALNISVP 284 + N W QR Sbjct: 241 IEHTLTNDWDLKLLTREEMLKDTTNRLYSVYKRMPSEVQDKWDSAYAQRIAEYRKGDLKG 300 Query: 285 YGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGE 344 I +Q+ +R Y A+V +D +GRLL+ L+ + ++TII +TSD G+ LGEHG Sbjct: 301 KALISWKYQQYMR-DYLATVLAVDENIGRLLNYLEKIGELDNTIIVYTSDQGFFLGEHGW 359 Query: 345 WAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELV 404 + K ++ +PLI P + ++ G S + V Sbjct: 360 FDKRFMYEECQRMPLIIRYP------------------------KAIKAGSTSSAISMNV 395 Query: 405 SLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYS 464 PT AG++VP S L EGK P + R+ Y Sbjct: 396 DFAPTFLDFAGVEVPSDIQGASLKPVLENEGKT----------------PADWRKAAYYH 439 Query: 465 QYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYF 524 Y P++ S+K Y IRT D++ + ++DI E+Y Sbjct: 440 YYEYPAE--------HSVK----RHYGIRTQDFK-----------LIHFYNDIDEWEMYD 476 Query: 525 VDSDPLQDHNMYNDSQ----GGDLFQLL 548 + +DP + +N++ ++ +L QLL Sbjct: 477 MKADPREMNNIFGKAEYAKKQKELMQLL 504 >4UPH-A nrPDB Length = 547 Score = 329 bits (842), Expect = 2e-90, Method: Composition-based stats. Identities = 111/532 (20%), Positives = 185/532 (34%), Gaps = 82/532 (15%) Query: 24 LGSETQANSTTDALNVLLIIVDDLRPS-LGCYGDKLVRSPNIDQLASHSLLFQNAFAQQA 82 + + + NVLLI D R L G V++PN+D LA +LF FA A Sbjct: 32 NPTSIEWRPSGKRPNVLLISADQWRGDCLSAVGHASVKTPNVDALAQDGVLFTRHFAGTA 91 Query: 83 VCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHP--- 139 +P+R + TG R+ S F + + GY G Sbjct: 92 PASPARATLYTGLYQMNHRVCRNGSPLD---ARFDNLALAARRGGYDPTLFGYTDTAPDP 148 Query: 140 -GISSNHTDDSPYSWSFPPYHPSS------EKYENTKTCRGPDGELHANLLCPV-----D 187 G+ N + Y P + +++ + RG ++ PV + Sbjct: 149 RGMDPNDPHLTTYEGVLPGFSARQLLPEHEKQWLSWLRSRGHPEATSRDIHIPVGATPGE 208 Query: 188 VLDV-PEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLEN 246 + DV P + + Q+ A + + + +P+F V + +PH PF P+ + +++ + Sbjct: 209 ISDVAPAYSKDETQTAFLAGEFIRWLGEQDAPWFAHVSFLRPHPPFSVPEPYNRMFTPSD 268 Query: 247 ---ITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFAS 303 A + E + P+ I + + S + IR Y+ Sbjct: 269 GPAFARAANREAEQAVHPLLAFALPLIGKDSFIYGGEGSAS--DWTSEDLSAIRAIYYGM 326 Query: 304 VSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYV 363 ++ +DTQ+GR+ AL ++ + T+I FTSDH +G+H K FD + HVPL+ Sbjct: 327 IAEVDTQLGRIWQALKNVGAWDDTLIIFTSDHAEMMGDHWMLGKGGFFDGSYHVPLVIRD 386 Query: 364 PGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCP 423 PG GRQ +FPTL GL Sbjct: 387 PGHPGG-----------------------AGRQVERFTSAADIFPTLCDRLGLVPDNHLD 423 Query: 424 VPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKP-SL 482 + L P R+ + R DI + +++ L Sbjct: 424 GGTLVPFLEG------------------GEPEGWRDAAFWEFDFR--DIAKGEAERHFGL 463 Query: 483 KDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHN 534 K IR ++Y + G P LY + DP++ N Sbjct: 464 KSNACNLAVIRDERFKYVHFAGLPPL-------------LYDLAKDPMELTN 502 >4UPK-A nrPDB Length = 538 Score = 324 bits (829), Expect = 8e-89, Method: Composition-based stats. Identities = 102/452 (22%), Positives = 171/452 (37%), Gaps = 54/452 (11%) Query: 31 NSTTDALNVLLIIVDDLRPSL--GCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSR 88 +S NVL II+D LR G D V P++ LA ++ F+ ++ C PSR Sbjct: 28 SSMGRQSNVLFIIIDQLRADCLWGALADH-VELPHLRALAQDAVSFRRHYSVTNPCGPSR 86 Query: 89 VSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVG--KVFHPGISSNHT 146 S LTG+ R + R N +T ++ GY+ + G + + Sbjct: 87 ASILTGQYAMNHRSVRNGTPLRHDTPNIAT---EMRKAGYLPLLFGYTDTSQDPRAYDAN 143 Query: 147 DDSPYSWSFP--PYHPSSEK-------YENTKTCRGPDGELHANLLCPV-DVLDVPEGTL 196 D + ++ FP +H +E +++ RG + +A + P D P Sbjct: 144 DPALKTYEFPMRGFHEVTEMRLEMSYPWQSHLKNRGYAFDDYAQVYVPRPDADGTPRLNG 203 Query: 197 P------DKQSTEQAIQLLEKMKTSASP-FFLAVGYHKPHIPFRYPKEFQKLYPLENITL 249 P D + Q L M A +F + Y +PH P P + +Y + L Sbjct: 204 PAMYRAEDSDTAFLTDQFLANMPAWAGQNWFAHLTYIRPHPPLVAPAPYNTMYDPAKLPL 263 Query: 250 APDPEVPDGLPPVAYNPWMDIRQREDVQA-LNISVPYGPIPVDFQRKIRQSYFASVSYLD 308 +P A +P+ R A + P + + +R Y + +D Sbjct: 264 PA--RLPGRDDETAEHPFFGPATRYSSPASFVLGFPDLEPTDETIQTLRAVYLGLATEVD 321 Query: 309 TQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTA 368 T +GR+++ L + + T+I T+DHG LG+ W K + +D A H PLI PG Sbjct: 322 THIGRVIAHLKETGQYDDTLIVVTADHGEMLGDRHSWGKMTVYDAAYHTPLIIRAPG--- 378 Query: 369 SLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFH 428 +PG E + L PT+ G ++P S Sbjct: 379 ----------------------CKPGHVVEAPTESIDLMPTILDWVGQEIPNAVDGRSLR 416 Query: 429 VELCREGKNLLKHFRFRDLE-EDPYLPGNPRE 459 L E + + + F +L+ +P P ++ Sbjct: 417 PFLTGEAPSDWRQYSFSELDISEPLDPTLWQQ 448 >2W8S-A nrPDB Length = 543 Score = 321 bits (823), Expect = 4e-88, Method: Composition-based stats. Identities = 117/544 (21%), Positives = 188/544 (34%), Gaps = 106/544 (19%) Query: 32 STTDALNVLLIIVDDLRPS-----LGCYGDK-LVRSPNIDQLASHSLLFQNAFAQQAVCA 85 S+ NVLLI+VD R + G + +++PN+D+L L F+N Sbjct: 28 SSMTRKNVLLIVVDQWRADFIPHLMRAEGREPFLKTPNLDRLCREGLTFRNHVTTCVPGG 87 Query: 86 PSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNH 145 P+R S LTG R N + + + GY +G Sbjct: 88 PARASLLTGLYLMNHRAVQNTVPLDQRHLN---LGKALRAIGYDPALIGYTTTTPDPRTT 144 Query: 146 TDDSPYS----------WSFPPYHPSSEKY------------ENTKTCRGPDGELHANLL 183 + P S + P+ E Y EN + P+GE H+ Sbjct: 145 SARDPRFTVLGDIMDGFRSVGAFEPNMEGYFGWVAQNGFELPENREDIWLPEGE-HSVPG 203 Query: 184 CPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYP 243 +P+ TE+A+ L+ PFFL +GY++PH PF + +Y Sbjct: 204 ATDKPSRIPKEFSDSTFFTERALTYLKG--RDGKPFFLHLGYYRPHPPFVASAPYHAMYK 261 Query: 244 LENITLAPDPEVPDGL---PPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSY 300 E++ E PD P+ + IR+ S + R++R +Y Sbjct: 262 AEDMPAPIRAENPDAEAAQHPLMKHYIDHIRRGSFFHGAEGSGA--TLDEGEIRQMRATY 319 Query: 301 FASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLI 360 ++ +D +GR+ + LD+ + T+I FTSDHG LG+H K + +PL+ Sbjct: 320 CGLITEIDDCLGRVFAYLDETGQWDDTLIIFTSDHGEQLGDHHLLGKIGYNAESFRIPLV 379 Query: 361 FYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPP 420 A Q G+ E + + PT+ G + P Sbjct: 380 IKD-----------------------AGQNRHAGQIEEGFSESIDVMPTILEWLGGETPR 416 Query: 421 RCPVPSFHVELCREGK------NLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQ 474 C S + EGK L F FRD+ Y +P + Q Sbjct: 417 ACDGRSL-LPFLAEGKPSDWRTELHYEFDFRDV-----------------FYDQPQNSVQ 458 Query: 475 WNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHN 534 + D SL I +Y+Y + P + + +DP + N Sbjct: 459 LSQDDCSLCV-------IEDENYKYVHFAALPPL-------------FFDLKADPHEFSN 498 Query: 535 MYND 538 + D Sbjct: 499 LAGD 502 >4UPI-A nrPDB Length = 576 Score = 319 bits (816), Expect = 3e-87, Method: Composition-based stats. Identities = 109/470 (23%), Positives = 180/470 (38%), Gaps = 81/470 (17%) Query: 25 GSETQANST-----TDALNVLLIIVDDLRPS-LGCYGDKLVRSPNIDQLASHSLLFQNAF 78 G+ET ++ T N+L I+ D LR L CYG + + +PNID+LA + F NA+ Sbjct: 12 GAETAVPNSSSVPMTQNRNILWIMCDQLRFDYLSCYGHERLNTPNIDKLAKRGVRFTNAY 71 Query: 79 AQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVF- 137 Q V PSR+S TGR + RV T+ + ++ G + +GK Sbjct: 72 VQATVAGPSRMSAYTGRYVRSHGSTQNGIPLRV---GEPTLGDHLRDVGMRNVLIGKTHM 128 Query: 138 -----------------------HPGISSNHTDDSPYSWSFPPYHPSS------------ 162 G + DD + + P+ Sbjct: 129 RPDLDGMKRLGIDPDSEIGARVGEGGFDAFDRDDGVHPTGYRKKEPAYNDYLRHAGFQAE 188 Query: 163 ---EKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPF 219 E + N+ +G + + L VPE T +A++ +E + P+ Sbjct: 189 NPWEFWANSAEGKGGENQSGWLLTHADKPARVPEEHSETAYMTRRAMEFMEAAEKDGRPW 248 Query: 220 FLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQAL 279 + Y KPH P+ P + ++ +++ P V A +P E+V + Sbjct: 249 CAHLSYIKPHWPYIVPAPYHDMFGPDDVK----PAVRSDEELKAAHPLFK-AMTEEVYSR 303 Query: 280 NISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWAL 339 N + + + K+ +Y + +D Q+G+L + + + L +T+I FT+DHG L Sbjct: 304 NFARD------EVREKVIPAYMGLIKQIDDQLGQLFAFMQERGLDENTMIVFTADHGDYL 357 Query: 340 GEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMD 399 G+H KY ++ A VPLI Y P D A G S Sbjct: 358 GDHWMGEKYLFYEAAAKVPLIIYDP-------------------SDKADATR--GTVSDA 396 Query: 400 LVELVSLFPTLAGLAGLQVP-PRCPVPSFHVELCREGKNLLKHFRFRDLE 448 LVE++ L PT AG P S L + + + + F +L+ Sbjct: 397 LVEMIDLAPTFVDYAGGVPPMHILEGKSLLPLLHDDDSSWDRQYVFSELD 446 >2VQR-A nrPDB Length = 543 Score = 314 bits (804), Expect = 6e-86, Method: Composition-based stats. Identities = 99/452 (21%), Positives = 162/452 (35%), Gaps = 67/452 (14%) Query: 32 STTDALNVLLIIVDDLRPS-----LGCYGD-KLVRSPNIDQLASHSLLFQNAFAQQAVCA 85 S+ NVLLI+VD R L G +++PN+D+L + F+N Sbjct: 28 SSMRKKNVLLIVVDQWRADFVPHVLRADGKIDFLKTPNLDRLCREGVTFRNHVTTCVPAG 87 Query: 86 PSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNH 145 P+R S LTG R N + + + GY +G Sbjct: 88 PARASLLTGLYLMNHRAVQNTVPLDQRHLN---LGKALRGVGYDPALIGYTTTVPDPRTT 144 Query: 146 TDDSPYSW----------SFPPYHPSSEKYENTKTCRGPDGELH-ANLLCPVD------- 187 + + P + P+ E Y G D H ++ P Sbjct: 145 SPNDPRFRVLGDLMDGFHPVGAFEPNMEGYFGWVAQNGFDLPEHRPDIWLPEGEDAVAGA 204 Query: 188 ---VLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPL 244 +P+ TE+A+ L+ PFFL +GY++PH PF + +Y Sbjct: 205 TDRPSRIPKEFSDSTFFTERALTYLKG--RDGKPFFLHLGYYRPHPPFVASAPYHAMYRP 262 Query: 245 ENIT---LAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYF 301 E++ A +P++ P+ IR+ Q S + R++R +Y Sbjct: 263 EDMPAPIRAANPDIEAAQHPLMKFYVDSIRRGSFFQGAEGSGA--TLDEAELRQMRATYC 320 Query: 302 ASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIF 361 ++ +D +GR+ S LD+ + T+I FTSDHG LG+H K D + +PL+ Sbjct: 321 GLITEVDDCLGRVFSYLDETGQWDDTLIIFTSDHGEQLGDHHLLGKIGYNDPSFRIPLVI 380 Query: 362 YVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPR 421 A + G E + + PT+ G ++P Sbjct: 381 KD-----------------------AGENARAGAIESGFTESIDVMPTILDWLGGKIPHA 417 Query: 422 CPVPSFHVELCREGK------NLLKHFRFRDL 447 C S + EG+ L + FRD+ Sbjct: 418 CDGLSL-LPFLSEGRPQDWRTELHYEYDFRDV 448 >2QZU-A nrPDB Length = 491 Score = 309 bits (792), Expect = 2e-84, Method: Composition-based stats. Identities = 92/404 (22%), Positives = 158/404 (39%), Gaps = 53/404 (13%) Query: 24 LGSETQANSTTDALNVLLIIVDDLRPS-LGCYGDKLVRSPNIDQLASHSLLFQNAFAQQA 82 L + QA N++ I+ D R +GC G + V++P++D+LAS + F NA + Sbjct: 15 LSTGLQAQEKQPTPNLVFIMADQYRGDAIGCIGKEPVKTPHLDKLASEGINFTNAISSYP 74 Query: 83 VCAPSRVSFLTGRRPDTTRLYDF-----NSYWRVHAGNFSTIPQYFKENGYVTMSVGKVF 137 V +P+R +TG P +++ Y + N K+ GY +GK Sbjct: 75 VSSPARGMLMTGMYPIGSKVTGNCNSETAPYGVELSQNARCWSDVLKDQGYNMGYIGKWH 134 Query: 138 HPGISS-------NHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLD 190 N + W P + + T ++ N P D Sbjct: 135 LDAPYKPYVDTYNNRGKVAWNEWCPPERRHGFDHWIAYGTYDYHLKPMYWNTTAPRDSFY 194 Query: 191 VPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFR-YPKEFQKLYPLENITL 249 P+ +++ +AI+ + K PF L V + PH + P ++++Y Sbjct: 195 YVNQWGPEYEAS-KAIEYINGQKDQKQPFALVVSMNPPHTGYELVPDRYKEIY------- 246 Query: 250 APDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGP----IPVDFQRKIRQSYFASVS 305 + DV+AL P P D+ R ++Y+A ++ Sbjct: 247 ----------------------KDLDVEALCKGRPDIPAKGTEMGDYFRNNIRNYYACIT 284 Query: 306 YLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYV-- 363 +D VGR++ AL L ++TI+ FTSDHG +G H K ++ + +P+I Sbjct: 285 GVDENVGRIIEALKQNNLFDNTIVVFTSDHGICMGAHENAGKDIFYEESMRIPMILSWPD 344 Query: 364 ---PGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELV 404 P ++ L A L+P L S+ + Q+ DL V Sbjct: 345 QIKPRKSDPLMIAFADLYPTLLSMMGFSKEIPETVQTFDLSNEV 388 >4UPL-A nrPDB Length = 569 Score = 291 bits (745), Expect = 5e-79, Method: Composition-based stats. Identities = 95/431 (22%), Positives = 159/431 (36%), Gaps = 65/431 (15%) Query: 29 QANSTTDALNVLLIIVDDLRPS-LGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPS 87 + + T +N+L I+ D LR L CYG K + +P+ID+LA+ + F A+ Q +C S Sbjct: 10 EKGAETAVMNILFIMFDQLRWDYLSCYGHKTLNTPHIDRLAAKGVRFDRAYIQSPICGSS 69 Query: 88 RVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVF---------- 137 R+S TGR + +V T+ + + G VGK Sbjct: 70 RMSTYTGRYVHSHGASWNGIPLKV---GEMTMGDHLRAAGMGCWLVGKTHMRADEEGMAR 126 Query: 138 --------------HPGISSNHTDDSPYSWSFPPY--HPSSEKYENTKTCRGPDGELHAN 181 G DD Y +++Y +G + + + Sbjct: 127 LGLEPDSLIGARVAECGFDVFERDDGMLPEGPDGYYDPDGAKEYNKFLRAKGYESDNPWH 186 Query: 182 LLCPVDVLD------------------VPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAV 223 + D + E T +A++ +E+ P+ + Sbjct: 187 DFANSGLDDEGNVQSGWFLKNATRPANIAEEDSETPYLTSRAMEFIEQ---QTGPWCCHL 243 Query: 224 GYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISV 283 Y KPH P+ P+ + ++ E++ + + +MD + E + Sbjct: 244 SYIKPHWPYIVPEPYASMFGPEHVQDVVRSDSERQNAHPLFKAFMDTKVGEAFSRQEV-- 301 Query: 284 PYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHG 343 + + +Y + D Q+GRL L+D T+I TSDHG LG+H Sbjct: 302 ---------RDAVIPAYMGLIKQADDQMGRLFKWLEDTGRMQDTMIVLTSDHGDFLGDHW 352 Query: 344 EWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEP--GRQSMDLV 401 K D +T VPLI Y P R + G ++ D A +E G+ +M ++ Sbjct: 353 MGEKTFFHDASTRVPLIIYDP-RPEADATRGSVCDALVESIDLAPTFVEAAGGKPAMHIL 411 Query: 402 ELVSLFPTLAG 412 E SL P L G Sbjct: 412 EGESLIPILHG 422 >1P49-A nrPDB Length = 562 Score = 291 bits (744), Expect = 5e-79, Method: Composition-based stats. Identities = 105/450 (23%), Positives = 179/450 (39%), Gaps = 71/450 (15%) Query: 34 TDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFL 92 N++L++ DDL GCYG+K +R+PNID+LAS + A + PSR +F+ Sbjct: 3 ASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLATPSRAAFM 62 Query: 93 TGRRPDTTRLYDFN--------SYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSN 144 TGR P + + ++ + + T + K+ GY T +GK +H G+S + Sbjct: 63 TGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGK-WHLGMSCH 121 Query: 145 HTDDSPYSWSFPPYHPSSEKYE----NTKTCRGPDGELHAN-----LLCPVDVLDVPEGT 195 D + P +H + Y N + C+ +G + + P+ ++ V T Sbjct: 122 SKTDFCHH---PLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLT 178 Query: 196 LPDKQSTEQAIQLLEK-MKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPE 254 L + + LL + S FLA + F + + + N + P Sbjct: 179 L----AALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPM 234 Query: 255 VPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPV------DFQRKIRQSYFA-SVSYL 307 D L QR + + Y + DF K + + +V + Sbjct: 235 SYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEM 294 Query: 308 DTQVGRLLSALDDLQLANSTIIAFTSDHGWALGE-------HG------EWAKYSNFDVA 354 D VG++L+ LD+L+LAN T+I FTSD G + E HG + K +N++ Sbjct: 295 DWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGG 354 Query: 355 THVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLA 414 VP I P +++ G++ + + +FPT+A LA Sbjct: 355 IRVPGILRWPR------------------------VIQAGQKIDEPTSNMDIFPTVAKLA 390 Query: 415 GLQVPPRCPVPSFHVELCREGKNLLKHFRF 444 G +P + + EGK+ F Sbjct: 391 GAPLPEDRIIDGRDLMPLLEGKSQRSDHEF 420 >3ED4-A nrPDB Length = 502 Score = 284 bits (726), Expect = 6e-77, Method: Composition-based stats. Identities = 117/543 (21%), Positives = 200/543 (36%), Gaps = 85/543 (15%) Query: 15 LVLSSVCVALGSETQANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLL 73 L+ +VC + N+++I+ DDL L YG ++V++PNID+LA + Sbjct: 6 LIGLAVCTGNAFSPALAAEAKQPNLVIIMADDLGYGDLATYGHQIVKTPNIDRLAQEGVK 65 Query: 74 FQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDF--NSYWRVHAGNFSTIPQYFKENGYVTM 131 F + +A + +PSR LTGR P T + + + N TI K GY T Sbjct: 66 FTDYYAPAPLSSPSRAGLLTGRMPFRTGIRSWIPSGKDVALGRNELTIANLLKAQGYDTA 125 Query: 132 SVGKVFHPGISSNHTD-DSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLD 190 +GK+ H + TD F ++ + T ++ P L Sbjct: 126 MMGKL-HLNAGGDRTDQPQAQDMGFDYSLANTAGFVTDATLDNAKERPRYGMVYPTGWLR 184 Query: 191 VPEGTLPDKQS-----TEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLE 245 + T + + + + L+ K S PFFL V + + H P PK++ +Y Sbjct: 185 NGQPTPRADKMSGEYVSSEVVNWLDNKKDS-KPFFLYVAFTEVHSPLASPKKYLDMY--S 241 Query: 246 NITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVS 305 A + PD + Y W D P+ + Y+A++S Sbjct: 242 QYMSAYQKQHPD----LFYGDWAD-------------KPWRGV---------GEYYANIS 275 Query: 306 YLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPG 365 YLD QVG++L + + ++TI+ FTSD+G E + + + + G Sbjct: 276 YLDAQVGKVLDKIKAMGEEDNTIVIFTSDNGPVTREARKVYELNLAGETD------GLRG 329 Query: 366 RTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVP 425 R +L E G ++ + Q G S V + PTLA + ++P Sbjct: 330 RKDNLWEGGIRVPAIIKYGKHLPQ----GMVSDTPVYGLDWMPTLAKMMNFKLPTDRTFD 385 Query: 426 SFHVELCREGKNLLKH----------FRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQW 475 + E K L + F+ +E G+ + +I + P+ Sbjct: 386 GESLVPVLEQKALKREKPLIFGIDMPFQDDPTDEWAIRDGDWKMIIDRNNKPK------- 438 Query: 476 NSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPD-------EFLANFSDIHAGELYFVDSD 528 Y++++ Y +G PD +FL +DI L D Sbjct: 439 ------------YLYNLKSDRYETLNLIGKKPDIEKQMYGKFLKYKTDIDNDSLMKARGD 486 Query: 529 PLQ 531 + Sbjct: 487 KPE 489 >4UG4-A nrPDB Length = 515 Score = 284 bits (725), Expect = 8e-77, Method: Composition-based stats. Identities = 130/516 (25%), Positives = 200/516 (38%), Gaps = 48/516 (9%) Query: 33 TTDALNVLLIIVDDLRPSLGCYG-DKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSF 91 TT N+L+I+VD L L G + +PN+ LA S F N + +CAP+R SF Sbjct: 5 TTGKPNILIIMVDQLNGKLFPDGPADFLHAPNLKALAKRSARFHNNYTSSPLCAPARASF 64 Query: 92 LTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNH------ 145 + G+ P TR+YD + ++ T + + GY T GK+ G H Sbjct: 65 MAGQLPSRTRVYDNAAEYQSS---IPTYAHHLRRAGYYTALSGKMHFVGPDQLHGFEERL 121 Query: 146 -TDDSPYSWS-FPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTE 203 TD P + P Y E+ + G + V ++ D + Sbjct: 122 TTDIYPADFGWTPDYRKPGERIDWWYHNLGS--------VTGAGVAEITNQMEYDDEVAF 173 Query: 204 QAIQLL-----EKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDG 258 A Q L E S P+ L V + PH P+ ++F LY +P Sbjct: 174 LANQKLYQLSRENDDESRRPWCLTVSFTHPHDPYVARRKFWDLYEDCEHLTPEVGAIPLD 233 Query: 259 LPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQ--RKIRQSYFASVSYLDTQVGRLLS 316 Q Q + +S Y V + R+ R++YFA++SYLD +VG L+ Sbjct: 234 E------------QDPHSQRIMLSCDYQNFDVTEENVRRSRRAYFANISYLDEKVGELID 281 Query: 317 ALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASL-PEAGE 375 L ++ + T+I F SDHG LGE G W K + F+ + VPL+ PG L Sbjct: 282 TLTRTRMLDDTLILFCSDHGDMLGERGLWFKMNFFEGSARVPLMIAGPGIAPGLHLTPTS 341 Query: 376 KLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREG 435 L D A +E R D V LV + + + + + REG Sbjct: 342 NLDVTPTLADLAGISLEEVRPWTDGVSLVPMVNGVERTEPVLMEYAAEASYAPLVAIREG 401 Query: 436 KNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTI 495 K + D E+ L +P EL ++ PR P + + +D++ + + Sbjct: 402 K-WKYVYCALDPEQLFDLEADPLELTNLAENPR---GPVDQATLTAFRDMRAAHWDMEAF 457 Query: 496 DYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQ 531 D V + + + G Y D PLQ Sbjct: 458 D----AAVRESQARRWVVYEALRNGAYYPWDHQPLQ 489 >6BIA-A nrPDB Length = 477 Score = 272 bits (694), Expect = 4e-73, Method: Composition-based stats. Identities = 108/526 (20%), Positives = 188/526 (35%), Gaps = 102/526 (19%) Query: 32 STTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVS 90 ++ N++LI+ DDL +G G K + +PNID LA F +A+ C PSR + Sbjct: 22 ASEQKPNIILIVADDLGYADVGFNGSKDIITPNIDDLAKSGTSFSDAYVAHPFCGPSRAA 81 Query: 91 FLTGRRPDTTRLYDFNSYWRVHAGNFST----IPQYFKENGYVTMSVGKVFHPGISSNHT 146 +TGR P FN R T I + EN Y T ++GK +H G + H Sbjct: 82 LMTGRYPHKIG-SQFNLPTRGSNVGVPTDAKFISKLLNENNYFTGALGK-WHMGDTPQHH 139 Query: 147 D-----DSPYSWSFPPYHPSSEKYENTKTCRGPDGELHA-NLLCPVD--VLDVPEGTLPD 198 D Y + ++ ++Y+ + G + + P++ +V E Sbjct: 140 PNKRGFDEYYGFLGGGHNYFPDQYQPQYKKQKAQGLKNIFEYITPLEHNGKEVKETQYIT 199 Query: 199 KQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDG 258 + +A+ ++K PFFL + Y+ PH P + E ++P Sbjct: 200 DALSREAVNFVDKAVNKKHPFFLYLAYNAPHTPLQAKDEDMAMFP--------------- 244 Query: 259 LPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSAL 318 + + K R++Y V +D VG+L+ AL Sbjct: 245 --------------------------------NIKNKDRKTYAGMVYAVDRGVGKLVEAL 272 Query: 319 DDLQLANSTIIAFTSDHGWALGEHGE-----WAKYSNFDVATHVPLIFYVPGRTASLPEA 373 ++T+I F SD+G L + K S + VP++F+ P + Sbjct: 273 KKNNQYDNTLIVFMSDNGGKLSKGANNFPLKAGKGSTQEGGFRVPMLFHWPKHVPA---- 328 Query: 374 GEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHV---E 430 G++ V + L+PT A LAG +V + ++ Sbjct: 329 --------------------GKRFSHPVSALDLYPTFAALAGAKVEENQHLDGTNMWPAF 368 Query: 431 LCREGK---NLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPS-DIPQWNSDKPSLKDIK 486 + E + R R D + N + + +Q P +I S+K + Sbjct: 369 IKNENPHKDEPIYALRHRKGYSDAAIRMNQWKALKVNQQPWQLFNIENDISEKHDVSKSN 428 Query: 487 IMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQD 532 + + W P + F + G + +D+ P D Sbjct: 429 KALLTDMVREMEKWSWDNQQP----SWFHETTEGVNWRLDAMPRFD 470 >5G2T-A nrPDB Length = 489 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 111/533 (20%), Positives = 179/533 (33%), Gaps = 134/533 (25%) Query: 33 TTDALNVLLIIVDDL-RPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSF 91 + N L+I D L + +G YG + ID++AS ++F NA+ + PSR + Sbjct: 20 QQEKPNFLIIQCDHLTQRVVGAYGQTQGCTLPIDEVASRGVIFSNAYVGCPLSQPSRAAL 79 Query: 92 LTGRRPDTTRLYDFNSYW--RVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDS 149 +G P T + +S N T+ F E+GY + GK G Sbjct: 80 WSGMMPHQTNVRSNSSEPVNTRLPENVPTLGSLFSESGYEAVHFGKTHDMGSLRGFKHKE 139 Query: 150 PYSWSF--PPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQ 207 P + F P + +++ + + TC E A+ Sbjct: 140 PVAKPFTDPEFPVNNDSFLDVGTC-------------------------------EDAVA 168 Query: 208 LLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPW 267 L PF + PH + E ++ I+ P PE+PD Sbjct: 169 YLSN--PPKEPFICIADFQNPHNICGFIGENAGVHTDRPIS-GPLPELPDNF-------- 217 Query: 268 MDIRQREDVQAL-NISVPYGPIPVDFQRKIRQSYFASVSY-------------LDTQVGR 313 DV+ NI P I +R + +++ +Y + QV Sbjct: 218 -------DVEDWSNIPTPVQYICCSHRRMTQAAHWNEENYRHYIAAFQHYTKMVSKQVDS 270 Query: 314 LLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYS-NFDVATHVPLIFYVPGRTASLPE 372 +L AL +TI+ +DHG + H K+ +D T+VP IF PG Sbjct: 271 VLKALYSTPAGRNTIVVIMADHGDGMASHRMVTKHISFYDEMTNVPFIFAGPG------- 323 Query: 373 AGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELC 432 + P D L +P + L PTL LAG+ VP S L Sbjct: 324 ----IKQQKKPVDH--LLTQPT---------LDLLPTLCDLAGIAVPAEKAGISLAPTLR 368 Query: 433 REGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSI 492 E + + PY+ +S+Y + G + Sbjct: 369 GE----------KQKKSHPYVVSEW-----HSEYEY----------------VTTPGRMV 397 Query: 493 RTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLF 545 R Y+YT ++ N + ELY + DP + N+ D + + Sbjct: 398 RGPRYKYTHYLEGNGE------------ELYDMKKDPGERKNLAKDPKYSKIL 438 >1FSU-A nrPDB Length = 492 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 117/532 (21%), Positives = 198/532 (37%), Gaps = 116/532 (21%) Query: 34 TDALNVLLIIVDDLRP-SLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFL 92 + +++ ++ DDL +G +G + +R+P++D LA+ +L N + Q + PSR L Sbjct: 1 SRPPHLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLLDNYYTQ-PLATPSRSQLL 58 Query: 93 TGRRPDTTRLYDFNSYWRVHAG----NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDD 148 TGR T L W + +PQ KE GY T VGK +H G+ Sbjct: 59 TGRYQIRTGL-QHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGK-WHLGMYRKECLP 116 Query: 149 SPYSW-SFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPE------GTLPDKQS 201 + + ++ Y SE Y + + C D C +D D E Sbjct: 117 TRRGFDTYFGYLLGSEDYYSHERCTLIDALN--VTRCALDFRDGEEVATGYKNMYSTNIF 174 Query: 202 TEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPP 261 T++AI L+ P FL + H P + P+E+ K Y Sbjct: 175 TKRAIALITN-HPPEKPLFLYLALQSVHEPLQVPEEYLKPYDF----------------- 216 Query: 262 VAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDL 321 Q K R Y VS +D VG + +AL Sbjct: 217 ------------------------------IQDKNRHHYAGMVSLMDEAVGNVTAALKSS 246 Query: 322 QLANSTIIAFTSDH-GWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPY 380 L N+T+ F++D+ G L W + GR SL E G + + Sbjct: 247 GLWNNTVFIFSTDNGGQTLAGGNNWP----------------LRGRKWSLWEGGVRGVGF 290 Query: 381 LDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELC-REGK--- 436 + ++ L + G ++ +L+ + PTL LA P+ F V EG Sbjct: 291 V----ASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSP 346 Query: 437 --NLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRT 494 LL + ++ P PR +A ++ S +P++++ S+ +IR Sbjct: 347 RIELLHNIDPNFVDSSPC----PRNSMAPAKDD--SSLPEYSAFNTSV------HAAIRH 394 Query: 495 IDYR----YTVWVGFNPDEFLANFSDIHAGE-------LYFVDSDPLQDHNM 535 +++ Y + P N S+I + + L+ +D DP + H++ Sbjct: 395 GNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDL 446 >4CXU-A nrPDB Length = 536 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 114/575 (19%), Positives = 199/575 (34%), Gaps = 122/575 (21%) Query: 34 TDALNVLLIIVDDLRP-SLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFL 92 + N L+I+ DDL +G +G + + +PN+D LA L + F + +P+R L Sbjct: 2 SKRPNFLVIVADDLGFSDIGTFGGE-IATPNLDALAIAGLRLTD-FHTASAASPTRSMLL 59 Query: 93 TGR-----------RPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGI 141 TG T L Y +P+ +E GY T+ GK +H G+ Sbjct: 60 TGTDHHIAGIGTMAEALTPELEGKPGYEGHLNERVVALPELLREAGYQTLMAGK-WHLGL 118 Query: 142 SSNHTDDSPYSWSF-----------------PPYHPSSEKYENTKTCRGPDGELHANLLC 184 T P++ F PPY S+ + + E + + L Sbjct: 119 KPEQT---PHARGFERSFALLPGAANHYGFEPPYDESTPRILKGTPALYVEDERYLDTL- 174 Query: 185 PVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYP- 243 PEG ++ +Q L K + + PFF + + PH P + P+E + Y Sbjct: 175 -------PEGFYSSDAFGDKLLQYL-KERDQSRPFFAYLPFSAPHWPLQAPREIVEKYRG 226 Query: 244 --------LENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRK 295 L LA E+ V +P + + + + +AL + Sbjct: 227 RYDAGPEALRQERLARLKELGLVEADVEAHPVLALTR--EWEALE------DEERAKSAR 278 Query: 296 IRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAK-------- 347 + Y A V +D +GR++ L ++T + F SD+G + K Sbjct: 279 AMEVYAAMVERMDWNIGRVVDYLRRQGELDNTFVLFMSDNGAEGALLEAFPKFGPDLLDF 338 Query: 348 -----YSNFDVATHVPLIFYVPGRTASLPEAGEKLFPY--------LDPFDSASQLMEPG 394 ++ + + R A A +L+ + +L G Sbjct: 339 LDRHYDNSLENIGRANSYVWYGPRWAQAATAPSRLYKAFTTQGGIRVPALVRYPRLSRQG 398 Query: 395 RQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLP 454 S ++ + PTL LAG++ P K +R R++ Sbjct: 399 AISHAFATVMDVTPTLLDLAGVRHPG-------------------KRWRGREI------- 432 Query: 455 GNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGY-SIRTIDYRYTVWVGFNPDEFLAN 513 PR S S + D+ ++ + G +IR D++ Sbjct: 433 AEPR---GRSWLGWLSGETEAAHDENTVTGWGLFGMRAIRQGDWKAVYLPAPVGPA---- 485 Query: 514 FSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLL 548 +LY + DP + H++ DSQ G L +L+ Sbjct: 486 -----TWQLYDLARDPGEIHDL-ADSQPGKLAELI 514 >4MHX-A nrPDB Length = 510 Score = 211 bits (537), Expect = 6e-55, Method: Composition-based stats. Identities = 110/533 (20%), Positives = 172/533 (32%), Gaps = 106/533 (19%) Query: 34 TDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLT 93 N LL++ DD G Y + + +P++D LA SLLF+NAF + +PSR S LT Sbjct: 20 ARPRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSSSPSRASLLT 79 Query: 94 GRRPDTTRLYDFNSYWRVHAG--NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPY 151 G +Y + ++P + G T +GK H G + + D Y Sbjct: 80 GLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKK-HVGPETVYPFDFAY 138 Query: 152 SWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEK 211 + EN VL V K + +Q + Sbjct: 139 T------------EENGS------------------VLQVGRNITRIKLLVRKFLQTQDD 168 Query: 212 MKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIR 271 PFFL V +H PH ++ + +PD P AY+P Sbjct: 169 -----RPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPD-WTPQAYDP----- 217 Query: 272 QREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAF 331 L++ VPY R + + +V +D VG +L L D + N T++ F Sbjct: 218 -------LDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIF 270 Query: 332 TSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLM 391 TSD+G + + + T PL+ P Sbjct: 271 TSDNGIPF----PSGRTNLYWPGTAEPLLVSSPEHPKRW--------------------- 305 Query: 392 EPGRQSMDLVELVSLFPTLAGLAGLQVPP---------RCPVPSFHVELCREGKNLLKHF 442 G+ S V L+ L PT+ + P S L E L Sbjct: 306 --GQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAE--PLWATV 361 Query: 443 RFRDLEEDPYLPGNPRELIAYSQ-------YPRPSDIPQWNSDKPSLKDIKIMGYSIRTI 495 + + R + + P I Q P+ +D+ RT Sbjct: 362 FGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLN-----RTT 416 Query: 496 DYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLL 548 + T W + + ELY DP + N+ D + L ++L Sbjct: 417 AGQPTGWY----KDLRHYYYRA-RWELYDRSRDPHETQNLATDPRFAQLLEML 464 >4FDJ-A nrPDB Length = 502 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 86/403 (21%), Positives = 146/403 (36%), Gaps = 88/403 (21%) Query: 37 LNVLLIIVDDLRP-SLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGR 95 N+LL+++DD+ LG YG+ +PN+D++A+ LLF N ++ + +PSR + LTGR Sbjct: 5 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLXSPSRAALLTGR 64 Query: 96 RPDTTRLYDFNSYWRVH----------AGNFSTIPQYFKENGYVTMSVGKVFHPGISSN- 144 P Y N++ R + +P+ K+ GYV+ VGK +H G Sbjct: 65 LPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGK-WHLGHRPQF 123 Query: 145 ----HTDDSPYSWS---FPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLP 197 H D + F PY + G + P+++ Sbjct: 124 HPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEF--PINLKTGEANLTQ 181 Query: 198 DKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPD 257 ++A+ +++ PFFL H P K F Sbjct: 182 IYL--QEALDFIKRQARH-HPFFLYWAVDATHAPVYASKPFLG----------------- 221 Query: 258 GLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSA 317 Q I +G++L Sbjct: 222 -----------------TSQRGRYGDAVREID-------------------DSIGKILEL 245 Query: 318 LDDLQLANSTIIAFTSDHGWAL-------GEHGEW--AKYSNFDVATHVPLIFYVPGRTA 368 L DL +A++T + FTSD+G AL G +G + K + F+ P + + PG Sbjct: 246 LQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVT 305 Query: 369 SLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLA 411 + + +L +D F ++ L S ++ ++L PTL Sbjct: 306 A-GQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLL 347 >1E2S-P nrPDB Length = 489 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 107/527 (20%), Positives = 170/527 (32%), Gaps = 122/527 (23%) Query: 37 LNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGR 95 N++LI DDL LGCYG +PN+DQLA+ L F + + ++ PSR + LTGR Sbjct: 3 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLATPSRAALLTGR 62 Query: 96 RPDTTRLYDFNSYWRVHAG---NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS 152 P +Y G T+ + GY+T GK +H G+ P+ Sbjct: 63 LPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK-WHLGVGPEGAFLPPHQ 121 Query: 153 WSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKM 212 F + + C+ + P D I LL + Sbjct: 122 -GFHRFLGIPYS-HDQGPCQ------NLTCFPPATPCDGG------CDQGLVPIPLLANL 167 Query: 213 KTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQ 272 A P P +P + Y L D + D P+ Sbjct: 168 SVEAQP---------PWLPGLEAR-----YMAFAHDLMADAQRQDR-------PFFLYYA 206 Query: 273 REDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFT 332 P +R R + S+ LD VG L++A+ DL L T++ FT Sbjct: 207 SHHTH-----YPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFT 261 Query: 333 SDHG---WALGEHG-----EWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPF 384 +D+G + G K + ++ P + + PG A Sbjct: 262 ADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPG-------------- 307 Query: 385 DSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPP-RCPVPSFHVELCREGKNLLKHFR 443 + +L + L PTLA LAG +P L GK+ Sbjct: 308 -----------VTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKS------ 350 Query: 444 FRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRY---- 499 PR+ + + P ++ +++RT Y+ Sbjct: 351 -------------PRQSLFF-YPSYPDEVRGV--------------FAVRTGKYKAHFFT 382 Query: 500 --TVWVGFNPDEFLANFSDIHAGE---LYFVDSDPLQDHNMYNDSQG 541 + D S + A E LY + DP +++N+ G Sbjct: 383 QGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAG 429 >3LXQ-A nrPDB Length = 450 Score = 88.5 bits (217), Expect = 7e-18, Method: Composition-based stats. Identities = 69/453 (15%), Positives = 124/453 (27%), Gaps = 113/453 (24%) Query: 35 DALNVLLIIVDDLRPS-LGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLT 93 N+++++ + L +G G + +PN+D+L F +A + T Sbjct: 84 KRKNLVILLQESLGAQFVGSLGGLPL-TPNLDELMQEGWQFTQMYATGTRSVRGIEAVTT 142 Query: 94 GRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSW 153 G P +R S + F TI KE GY T + D+ ++ Sbjct: 143 GFPPSPSRAVVKLSKSQT---GFFTIADLLKEQGYHTQFI-------YGGEANFDNMKTF 192 Query: 154 SFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMK 213 F ++ K P + D+ +A + E++ Sbjct: 193 FFGN---GFDQIVEEKNYTNPGFVGSWGV--------------SDEDLYNKADEEFERLS 235 Query: 214 TSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQR 273 PFF V H P+ YP+ + Y E++T Sbjct: 236 KGDKPFFSLVFTSSNHSPYEYPEGKIEQYDSEHMTRN----------------------- 272 Query: 274 EDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTS 333 +V Y D +G + TI + Sbjct: 273 ----------------------------NAVKYSDYALGTFFDKAKKSSYWDDTIFIVIA 304 Query: 334 DHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEP 393 DH + + H+P + Sbjct: 305 DH-----DARVFGANLVPVKHFHIPALIIGKDIQP------------------------- 334 Query: 394 GRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFR--FRDLEEDP 451 R+ + + + PTL L G+ L RE + + + F L D Sbjct: 335 -RKDDRIANNIDMPPTLLSLIGVDAKTPMIGRDLTKPLAREDERAMMQYDKNFGYLTRDN 393 Query: 452 YLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKD 484 + +P E ++ +Y S + S+ D Sbjct: 394 LVVLSPGEKVSTMEYDFESQTMKPLEVDESVID 426 >5I5H-A nrPDB Length = 586 Score = 65.0 bits (156), Expect = 9e-11, Method: Composition-based stats. Identities = 33/165 (20%), Positives = 63/165 (38%), Gaps = 5/165 (3%) Query: 244 LENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALN-ISVPYGPIPVDFQRKIRQSYFA 302 L + ++ D + W+ +ED + + +S I Q+ + Y Sbjct: 359 LSDFSMPSVRTQSDEQTATQWINWLGRYAQEDNRWFSWVSFNGTNIDDSNQQAFARKYSR 418 Query: 303 SVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFY 362 + +D Q+ R+L+AL D ++T++ T+ G L E E +S+ VPL+ + Sbjct: 419 AAGNVDDQINRVLNALRDSGKLDNTVVIITAGRGIPLSEEEETFDWSH--GHLQVPLVIH 476 Query: 363 VPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLF 407 PG A A + L+ + + + LF Sbjct: 477 WPGTPAQRINALTDHTDLMTTLMQR--LLHVSTPASEYSQGQDLF 519 >5I5F-A nrPDB Length = 586 Score = 63.4 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 37/220 (16%), Positives = 75/220 (34%), Gaps = 14/220 (6%) Query: 244 LENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALN-ISVPYGPIPVDFQRKIRQSYFA 302 L + ++ D + W+ +ED + + IS I Q+ + Y + Sbjct: 359 LSDFSMPAAQTQSDAQTASQWIDWLGRYAQEDNRWFSWISFNGTNIDDSNQKNFVKRYAS 418 Query: 303 SVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFY 362 + S +D Q+ R+L+AL + ++T++ T+ G L ++ VPL+ + Sbjct: 419 AASDVDAQINRVLNALREAGKFDNTVVIITAGRGIPLTPEEN--RFDWSQGHLQVPLVIH 476 Query: 363 VPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLF--PTLAGLAGLQVPP 420 PG A + L+ + + + +F P Sbjct: 477 WPGTPAQRINVLTDHTDVMTTLMQR--LLHVSTPANEYSQGQDIFTVPRRHNWVTAADGS 534 Query: 421 RCPV--PSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPR 458 + P + L G H++ DL + P+ Sbjct: 535 TLAITTPQMTLVLNNNG-----HYQTYDLHGEKIKDQKPQ 569 >4UOP-A nrPDB Length = 442 Score = 61.9 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 54/400 (13%), Positives = 117/400 (29%), Gaps = 93/400 (23%) Query: 22 VALGSETQANSTTDALNVLLIIVDDLRPSLG---CYGDKLVRSPNIDQLASHSLLFQNAF 78 V++ S N++++ ++ + +L G + +P +D L + ++ F Sbjct: 43 VSVKSNPDYFGAAKGKNLIIVQLESFQRNLTNVKINGQSI--TPTLDGLQNETMYSNQFF 100 Query: 79 AQQAVCAPSRV--SFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKV 136 + + S T P + Y + ++P+ +N Y T Sbjct: 101 QTVSKSNTADAEWSVYTSTFP--SGYYTNTQTYGDR--VIPSMPRLLGKNDYKTA----T 152 Query: 137 FHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTL 196 FH +S + D Y + ++ + G Sbjct: 153 FHTNDASFYNRDEFYPAV--GFDKFYDR--------------------KFFGDEDVIGFS 190 Query: 197 PDKQSTE-QAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEV 255 P + +A +LE+ + F+ + H+PF PK+ Sbjct: 191 PSDEVLYNKAFPILEEQYKNNQKFYAQLISVSSHMPFDIPKD------------------ 232 Query: 256 PDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLL 315 +P D + +YF +V Y D Q+G + Sbjct: 233 ---------------------------KQEIDLPSDLKDTELGNYFEAVHYADKQLGEFI 265 Query: 316 SALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVA----------THVPLIFYVPG 365 L D + + +++ F DH + + + + +P + PG Sbjct: 266 QKLKDSGIWDDSVVVFYGDHHIIKTDQLPEEQKKYVNRSTQLKAEPADDYRIPFFLHYPG 325 Query: 366 RTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVS 405 + P ++ G Q M ++++ Sbjct: 326 MENPGEIKNVGGEIDIMPTVMNLLGIKTGDQIMFGTDILN 365 >4UOO-A nrPDB Length = 459 Score = 54.2 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 32/153 (20%), Positives = 52/153 (33%), Gaps = 18/153 (11%) Query: 238 FQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIR 297 F Y N + + D ++ Q+ + P P+D + Sbjct: 181 FDASYYDMNEADVSNYGLKDKPFFKESEEYLSSLQQPFYTKFITLTNHFPYPIDEKDASI 240 Query: 298 Q----------SYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGE--- 344 +YF + YLD V + L L ++++I DH H E Sbjct: 241 APATTGDSSVDTYFQTARYLDESVKSFVDYLKKSGLYDNSVIIMYGDHYGISDNHEEAMT 300 Query: 345 --WAK-YSNFD--VATHVPLIFYVPGRTASLPE 372 K Y+ F+ A VPL+ +VPG + E Sbjct: 301 KILGKDYNTFENAQAQRVPLMIHVPGVQGGVQE 333 >5XWI-A nrPDB Length = 567 Score = 49.9 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 72/456 (15%), Positives = 130/456 (28%), Gaps = 63/456 (13%) Query: 32 STTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCA--PSRV 89 + T ++ I VD L + + + +L S +F + A P Sbjct: 36 AATPPKLIVAISVDQFSADLFSE-YRQYYTGGLKRLTSEGAVFPRGYQSHAATETCPGHS 94 Query: 90 SFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDS 149 + LTG RP T + N + + Y PG SS+ + S Sbjct: 95 TILTGSRPSRTGIIANNWFDLDAKREDKNL--------YCAE---DESQPGSSSDKYEAS 143 Query: 150 PYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCP-VDVLDVPEGTLPDKQSTEQAIQL 208 P P + G+ A ++ V P + + + Sbjct: 144 PLHLKVPTLGGRMKAANPATRVVSVAGKDRAAIMMGGATADQVWWLGGPQGYVSYKGVAP 203 Query: 209 LEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWM 268 + F + +P+ F P + + A + V G + Sbjct: 204 TPLVTQVNQAFAQRLA--QPNPGFELPAQ---CVSKDFPVQAGNRTVGTGRFARDAGDYK 258 Query: 269 DIRQREDVQALNISVPYGPIPVDFQRKIRQS-----------YFA------------SVS 305 R + A+ ++ I K Q+ Y V Sbjct: 259 GFRISPEQDAMTLAFAAAAIENMQLGKQAQTDIISIGLSATDYVGHTFGTEGTESCIQVD 318 Query: 306 YLDTQVGRLLSALDDLQLANSTIIAFTSDHGWA-LGEHGEWAKYSNFDVATHVPLIFY-- 362 LDT++G LD + ++ T+DHG L E + + + V + Sbjct: 319 RLDTELGAFFDKLDKDGI--DYVVVLTADHGGHDLPERH---RMNAMPMEQRVDMALTPK 373 Query: 363 -----------VPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLA 411 +PG+ + G Y D +A+Q +++ + T+ Sbjct: 374 ALNATIAEKAGLPGKK-VIWSDGPSGDIYYDKGLTAAQRARVETEALKYLRAHPQVQTVF 432 Query: 412 GLAGLQVPPRCPVPSFHVELCREGKNLLKHFRFRDL 447 A + P P L +E + R DL Sbjct: 433 TKAEIAATPSPSGPPESWSLIQEARASFYPSRSGDL 468 >6BNF-A nrPDB Length = 344 Score = 48.0 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 45/309 (14%), Positives = 93/309 (30%), Gaps = 30/309 (9%) Query: 120 PQYFKENGYVTM---SVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDG 176 + NGY + K+ G N + + S P Y + Sbjct: 43 ADHASFNGYQRATFPHMDKLIGLGQVHNFGNVTSCGTSTAYSVPCMFSYLGAEKYDVDTA 102 Query: 177 ELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSA---SPF------FLAVGYHK 227 + H N++ +D L V + ++ + L + SP Sbjct: 103 DYHENVIDTLDRLGVAILWRDNNSDSKGVMNRLPAKQYQDYKNSPLQGGNNTICH---TN 159 Query: 228 PHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYN-PWMDIRQREDVQALNISVPYG 286 P+ R L +++ + ++ L + + P R ++ Sbjct: 160 PYDECRDVGMLVDL--DDHVKAHANQDILIVLHQMGNHGPAYYKRYDDEFAQFLPVCTSS 217 Query: 287 PIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGE----- 341 + ++ + +Y ++ D + + + L A+ T + + SDHG +LGE Sbjct: 218 ELAECERQTVINAYDNALLATDDFLKQTIDWLAAQTHAD-TAMLYLSDHGESLGEKGVYL 276 Query: 342 HGEWAKYSNFDVATHVPLIFYV----PGRTASLPEAGEKLFP-YLDPFDSASQLMEPGRQ 396 HG K +P + ++ P A+ P AG + + Sbjct: 277 HGM-PKAFAPKEQLSIPALLWLGADTPFAVANSPTAGFSHDAITPTLLNLFDVSTQATAD 335 Query: 397 SMDLVELVS 405 V + Sbjct: 336 KTAFVNPLD 344 >5FGN-A nrPDB Length = 550 Score = 47.6 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 46/102 (45%), Gaps = 5/102 (4%) Query: 265 NPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLA 324 P R E + + I + + +Y +V Y+D + +++ L++ Sbjct: 384 GPTYYERYTEAERKFTPTCDTNEINKCTRATLVNTYDNTVLYVDQFIDKVIRKLENRDDL 443 Query: 325 NSTIIAFTSDHGWALGEHGEWAKYSNFD----VATHVPLIFY 362 S ++ + SDHG +LGE+G + + + TH+P++ + Sbjct: 444 ES-VVHYVSDHGESLGENGMYLHAAPYAIAPSGQTHIPMVMW 484 >4KAV-A nrPDB Length = 335 Score = 47.6 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 46/102 (45%), Gaps = 5/102 (4%) Query: 265 NPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLA 324 P R E + + I + + +Y +V Y+D + +++ L++ Sbjct: 175 GPTYYERYTEAERKFTPTCDTNEINKCTRATLVNTYDNTVLYVDQFIDKVIRKLENRDDL 234 Query: 325 NSTIIAFTSDHGWALGEHGEWAKYSNFD----VATHVPLIFY 362 S ++ + SDHG +LGE+G + + + TH+P++ + Sbjct: 235 ES-VVHYVSDHGESLGENGMYLHAAPYAIAPSGQTHIPMVMW 275 >1O99-A nrPDB Length = 511 Score = 44.5 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 43/205 (20%), Positives = 66/205 (32%), Gaps = 39/205 (19%) Query: 228 PHIPFRYPKEFQKLYPLENITLAPDPEVP--DGLPPVAYNPWMDIRQRE---DVQALNIS 282 PH+ F ++ +P E+ L P+VP D P ++ D +E D I Sbjct: 338 PHVTFFMSGGREEEFPGEDRILINSPKVPTYDLKPEMSAYEVTDALLKEIEADKYDAIIL 397 Query: 283 VPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEH 342 P V K+ + +V +D +G+++ A+ I T+DHG A Sbjct: 398 NYANPDMVGHSGKLEPT-IKAVEAVDECLGKVVDAILAKGG----IAIITADHGNADEVL 452 Query: 343 GEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVE 402 K VP+I + G + D Sbjct: 453 TPDGKPQTAHTTNPVPVIV-----------------------------TKKGIKLRDGGI 483 Query: 403 LVSLFPTLAGLAGLQVPPRCPVPSF 427 L L PT+ L GL P S Sbjct: 484 LGDLAPTMLDLLGLPQPKEMTGKSL 508 >2W8D-A nrPDB Length = 436 Score = 43.0 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 59/405 (14%), Positives = 114/405 (28%), Gaps = 126/405 (31%) Query: 33 TTDALNVLLIIVDDLRP---SLGCYGDKLVRSPNIDQLA--SHSLLFQNAFAQQAVCAPS 87 + NV+ + ++ L+ G ++ +P +++LA + + F N F Q S Sbjct: 28 KAEGKNVIYVSLESLQSFIIDYKIDGKEV--TPFLNKLAHDNETFYFDNFFHQTGQGKTS 85 Query: 88 RVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTI---PQYFKENGYVTMSVGKVFHPGISSN 144 F+ LY +T+ P K Y + + Sbjct: 86 DAEFM-----MENSLYPLAQGSVFVNKAQNTLQSVPAILKSKNYTSAT------------ 128 Query: 145 HTDDSPYSWSFPPYHPSSEKYENTKTCRGPDG--ELHANLLCPVDVLDVPEGTLPDKQST 202 +H +++ + N +G + + ++ + + DK Sbjct: 129 -------------FHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFF 175 Query: 203 EQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPV 262 ++++ LLE + PF+ H PF + Sbjct: 176 KESMPLLESLP---QPFYTKFITLSNHFPFGMDEGDTDF--------------------- 211 Query: 263 AYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQ 322 DF + +YF S YLD + + + L Sbjct: 212 -------------------------PAGDFGDSVVDNYFQSAHYLDQSIEQFFNDLKKDG 246 Query: 323 LANSTIIAFTSDHGWALGEHGEW-------AKYSNFDVA--THVPLIFYVPGRTASLPEA 373 L + +II DH H + + +++D A VPL + G Sbjct: 247 LYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIHAAGV------- 299 Query: 374 GEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQV 418 G + V + PT+ L G+ Sbjct: 300 -------------------KGEKVHKYAGDVDVAPTILHLLGVDT 325 >4TN0-A nrPDB Length = 325 Score = 42.6 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 44/102 (43%), Gaps = 5/102 (4%) Query: 265 NPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLA 324 P R + + + + + +Y ++ Y D + ++ L + + Sbjct: 158 GPTYYKRYPSEFKKFTPTCDTNELSKCDSEALINTYDNTLLYTDYLLSEIIKLLKEQKSY 217 Query: 325 NSTIIAFTSDHGWALGEHGEWAKYSNFDVA----THVPLIFY 362 S++ + SDHG +LGE+G + + +A TH+P IF+ Sbjct: 218 ESSLF-YLSDHGESLGENGIYLHGMPYAIAPSYQTHIPAIFW 258 >5UDY-A nrPDB Length = 422 Score = 42.2 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 20/117 (17%), Positives = 43/117 (36%), Gaps = 18/117 (15%) Query: 30 ANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLL---FQNAFAQQAVCAP 86 S +LL+ D R + D+ V +PN+D +A + AF + +P Sbjct: 13 VQSQGSQNKLLLVSFDGFRWNY----DQDVDTPNLDAMARDGVKARYMTPAFVT--MTSP 66 Query: 87 SRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISS 143 + +TG+ + + Y + + +P + T+ + + + G Sbjct: 67 CHFTLVTGKYIENHGVVHNMYY---NTTSKVKLPYH------ATLGIQRWWDNGSVP 114 Score = 31.8 bits (70), Expect = 0.72, Method: Composition-based stats. Identities = 26/121 (21%), Positives = 43/121 (35%), Gaps = 15/121 (12%) Query: 303 SVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWA--------LGEHGEWAKYSNFDVA 354 V +D VG L ++ L + + TSDHG L E ++ ++ D+ Sbjct: 204 MVRQVDRTVGYLRESIARNHLTDRLNLIITSDHGMTTVDKRAGDLVEFHKFPNFTFRDIE 263 Query: 355 THVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQL----MEPGRQSMDLVELVSLFPTL 410 L+ Y P LP+ G Y D+ +L E ++ + P L Sbjct: 264 FE--LLDYGPNGML-LPKEGRLEKVYDALKDAHPKLHVYKKEAFPEAFHYANNPRVTPLL 320 Query: 411 A 411 Sbjct: 321 M 321 >3E2D-A nrPDB Length = 502 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 49/329 (14%), Positives = 92/329 (27%), Gaps = 46/329 (13%) Query: 37 LNVLLIIVDDLRPS-LGCYGDKLVRSPN---------IDQLASHSLLFQ------NAFAQ 80 NV+L+I D + P +G ++PN I QLA ++ +A Sbjct: 4 KNVILMIGDGMGPQQVGLLETYANQAPNSIYKGNKTAIYQLAQEGVIGSSLTHPEDAIVV 63 Query: 81 QAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKV--FH 138 + C+ + TG + T+ + K+ G T V H Sbjct: 64 DSACSAT--MLATGIYS-----SSEVIGIDSQGNHVETVLEKAKKAGKATGLVSDTRLTH 116 Query: 139 PGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPD 198 +S S +S+ G H P D E Sbjct: 117 ATPASFAAHQPHRSL---ENQIASDMLATGADVMLSGGLRHW---IPKSTNDKGETYKQL 170 Query: 199 KQSTEQAIQLLEKMKTSASPFFLA------VGYHKPHIPFRYPKEFQKLYPLENITLAPD 252 ++ T+ + L K K + A + +++ + + L+ + Sbjct: 171 EKLTQGDVYLKSKRKDDRNLLTEAEKDGYQLAFNRNMLDDAKGDKLLGLFAYSGMDDGIA 230 Query: 253 PEVPDGLPPVAYNPWMDIRQR------EDVQALNISVPYGPIPVDFQRKIRQSYFASVSY 306 ++ Q+ +D + V G I + + Sbjct: 231 YSNKKKSGERTQPSLKEMTQKALNILSKDEDGFFLMVEGGQIDWAGHSNDAGTMLHELLK 290 Query: 307 LDTQVGRLLSALDDLQLANSTIIAFTSDH 335 D + + D TI+ T+DH Sbjct: 291 FDEAIQTVYEWAKDR---EDTIVIVTADH 316 >5KGM-A nrPDB Length = 552 Score = 40.3 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 49/273 (17%), Positives = 79/273 (28%), Gaps = 37/273 (13%) Query: 160 PSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSA-SP 218 ++Y++ + L + P +L S + + E + S Sbjct: 295 MGMDRYKDCNSKLAHPSNLQV-YGMTQYKAEFPFKSLFPPASNKNVLA--EWLAEQKVSQ 351 Query: 219 FFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPD-GLPPVAYNPWMDIRQREDVQ 277 F A H+ F + +K + E L P P+V L P + + E ++ Sbjct: 352 FHCAETEKYAHVTFFFNGGLEKQFEGEERCLVPSPKVATYDLQPEMSAAGVADKMIEQLE 411 Query: 278 ALNISVPYGPIPVDFQRKIRQSYFASVSY---LDTQVGRLLSALDDLQLANSTIIAFTSD 334 A Y A+V D +GR+ A + + T+D Sbjct: 412 AGTHPFIMCNFAPPDMVGHTGVYEAAVKACEATDIAIGRIYEATQKHGYS----LMVTAD 467 Query: 335 HGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPG 394 HG A VPL PG F ++DP D L Sbjct: 468 HGNAEKMKAPDGGKHTAHTCYRVPLTLSHPG------------FKFVDPADRHPALC--- 512 Query: 395 RQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSF 427 + PT+ + GL P S Sbjct: 513 ----------DVAPTVLAIMGLPQPAEMTGVSI 535 Score = 31.8 bits (70), Expect = 0.69, Method: Composition-based stats. Identities = 14/48 (29%), Positives = 23/48 (47%), Gaps = 3/48 (6%) Query: 25 GSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVR--SPNIDQLASH 70 G NS+ V LI++D S YG+ ++ +P +D+L S Sbjct: 18 GMAMANNSSVANK-VCLIVIDGWGVSEDPYGNAILNAQTPVMDKLCSG 64 >2W5S-A nrPDB Length = 424 Score = 40.3 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 29/154 (18%), Positives = 49/154 (31%), Gaps = 21/154 (13%) Query: 299 SYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVP 358 Y + YLD + ++ L L ++++I DH H + + T Sbjct: 223 GYIQTARYLDEALEEYINDLKKKGLYDNSVIMIYGDHYGISENHNNAMEKLLGEKIT--- 279 Query: 359 LIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQV 418 P + L G + G + + V + PT+ LAG+ Sbjct: 280 -----PAKFTDLNRTGFWIKIPGKS----------GGINNEYAGQVDVMPTILHLAGIDT 324 Query: 419 PPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPY 452 F +L +G N + FR D Y Sbjct: 325 KNYL---MFGTDLFSKGHNQVVPFRNGDFITKDY 355 >5MX9-A nrPDB Length = 324 Score = 39.5 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 36/253 (14%), Positives = 77/253 (30%), Gaps = 15/253 (5%) Query: 120 PQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELH 179 + + NGY + ++ +N + + S P Y + Sbjct: 34 ADHVQFNGYGRETFPQLAKVDGLANFSQVTSCGTSTAYSVPCMFSYLGQDDYDVDTAKYQ 93 Query: 180 ANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPH----IPFRYP 235 N+L +D L V + ++ + L A+ +F P+ Sbjct: 94 ENVLDTLDRLGVGILWRDNNSDSKGVMDKL-----PATQYFDYKSATNNTICNTNPYNEC 148 Query: 236 KEFQKLYPLENITLAPDP--EVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQ 293 ++ L L++ A + + + P R E + Sbjct: 149 RDVGMLVGLDDYVSANNGKDMLIMLHQMGNHGPAYFKRYDEQFAKFTPVCEGNELAKCEH 208 Query: 294 RKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEW----AKYS 349 + + +Y ++ D + + + L + + + SDHG +LGE+G + Sbjct: 209 QSLINAYDNALLATDDFIAKSIDWLKTHEANYDVAMLYVSDHGESLGENGVYLHGMPNAF 268 Query: 350 NFDVATHVPLIFY 362 VP F+ Sbjct: 269 APKEQRAVPAFFW 281 >4LR2-A nrPDB Length = 401 Score = 38.8 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 17/33 (51%) Query: 304 VSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG 336 + +D +G L+ L L L + + TSDHG Sbjct: 192 LKKIDDLIGDLVQRLKMLGLWENLNVIITSDHG 224 >5JTL-E nrPDB Length = 471 Score = 38.8 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 51/347 (14%), Positives = 87/347 (25%), Gaps = 55/347 (15%) Query: 32 STTDALNVLLIIVDDLRPSLGCYGDKLVRSPN-----IDQLASHSLLFQNAFAQQAV--- 83 S A N++L+I D + S ID L + A+ Sbjct: 60 SDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALP-----LTGQYTHYALNKK 114 Query: 84 ---------CAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVG 134 A S ++ TG + Y+ +H + TI + K G T +V Sbjct: 115 TGKPDYVTDSAASATAWSTG-----VKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVS 169 Query: 135 -----KVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTC--------------RGPD 175 + ++ T Y S E G Sbjct: 170 TAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGG 229 Query: 176 GELHANLLCPVDVLD---VPEGTLPDKQSTEQA--IQLLEKMKTSASPFFLAVGYHKPHI 230 + A + + Q A + + + L + P Sbjct: 230 AKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVR 289 Query: 231 PFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQ-ALNISVPYGPIP 289 + +T P+P+ D +P +A I + + V I Sbjct: 290 WLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASID 349 Query: 290 VDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG 336 LD V R L +T++ T+DH Sbjct: 350 KQDHAANPCGQIGETVDLDEAVQRALEFAKKEG---NTLVIVTADHA 393 >5VEN-A nrPDB Length = 416 Score = 38.0 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 24/156 (15%), Positives = 42/156 (26%), Gaps = 17/156 (10%) Query: 304 VSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYV 363 +S +D ++G L+ L +L N+ + TSDHG + + H LI + Sbjct: 194 ISDVDHKLGYLIKMLKRAKLWNNVNLIVTSDHGMTQCSKQRVIELDRYLDKEHYTLIDHS 253 Query: 364 PGRTASLPEAGEKLFPYLDPFDSASQLM---EPGRQSMDLVELVSLFPTLA--------- 411 P E + + E + + P +A Sbjct: 254 PVAAILPKEGKFDEVYDALAGAHPNLTVYKKEEIPERWHYKHNDRVQPIVAVADEGWYIL 313 Query: 412 -----GLAGLQVPPRCPVPSFHVELCREGKNLLKHF 442 + H G K+F Sbjct: 314 QNKSDDFLLGNHGYDNALAEMHPIFLAHGPAFRKNF 349 >4QAX-A nrPDB Length = 513 Score = 37.6 bits (85), Expect = 0.014, Method: Composition-based stats. Identities = 29/208 (13%), Positives = 58/208 (27%), Gaps = 45/208 (21%) Query: 228 PHIPFRYPKEFQKLYPLENITLAPDPEV--PDGLPPVAYNPWMDI------RQREDVQAL 279 PH+ + + + E L P+V D P ++ D + D+ L Sbjct: 340 PHVTYFMSGGRNEEFKGERRRLIDSPKVATYDLKPEMSAYEVKDALLEELNKGDLDLIIL 399 Query: 280 NISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWAL 339 N + P ++ + +D +G ++ + D+ T+DHG Sbjct: 400 NFANPDMVGHSGMLEPTIKA----IEAVDECLGEVVDKILDM----DGYAIITADHG--- 448 Query: 340 GEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMD 399 + + ++ + + G + Sbjct: 449 --------------------------NSDQVLTDDDQPMTTHTTNPVPVIVTKEGVTLRE 482 Query: 400 LVELVSLFPTLAGLAGLQVPPRCPVPSF 427 L L PTL L ++ P S Sbjct: 483 TGRLGDLAPTLLDLLNVEQPEDMTGESL 510 >5YLE-A nrPDB Length = 334 Score = 37.6 bits (85), Expect = 0.015, Method: Composition-based stats. Identities = 39/264 (14%), Positives = 79/264 (29%), Gaps = 15/264 (5%) Query: 120 PQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELH 179 + NGY + ++ +N ++ + S P Y + Sbjct: 35 ADHVSFNGYERDTFPQLAKIDGVTNFSNVTSCGTSTAYSVPCMFSYLGADEYDVDTAKYQ 94 Query: 180 ANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPH----IPFRYP 235 N+L +D L V + ++ + L + F P+ Sbjct: 95 ENVLDTLDRLGVSILWRDNNSDSKGVMDKL-----PKAQFADYKSATNNAICNTNPYNEC 149 Query: 236 KEFQKLYPLENITLAPDP--EVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQ 293 ++ L L++ A + + + P R E + Sbjct: 150 RDVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVCEGNELAKCEH 209 Query: 294 RKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEW----AKYS 349 + + +Y ++ D + + + L A + + SDHG +LGE+G + Sbjct: 210 QSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESLGENGVYLHGMPNAF 269 Query: 350 NFDVATHVPLIFYVPGRTASLPEA 373 VP F+ +T P A Sbjct: 270 APKEQRSVPAFFWTDKQTGITPMA 293 >5VPU-A nrPDB Length = 523 Score = 37.2 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 41/210 (19%), Positives = 73/210 (34%), Gaps = 49/210 (23%) Query: 229 HIPFRYPKEFQKLYPLENITLAPDPEV--PDGLPPVAYNPWMDIRQREDVQALNISVPYG 286 H+ F + + YP E L P P V D P ++ E V+A+N S Y Sbjct: 347 HVTFFFSGGREDEYPGEKRILIPSPNVATYDLKPEMSAYEV----TDELVKAIN-SGEYD 401 Query: 287 PIPVDFQRKIRQSYFA-------SVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG--W 337 + V++ + +V +DT +GR+ A+ +A + T+DHG Sbjct: 402 LLVVNYANGDMVGHTGVFDAAVKAVEAVDTCLGRVYEAV----MAKKGHMLITADHGNVE 457 Query: 338 ALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQS 397 + ++ ++ VP I+ P + + + E G Sbjct: 458 QMQDYESGQVHTQHTTEL-VPFIYVGP---------------------TQATIAEGGV-- 493 Query: 398 MDLVELVSLFPTLAGLAGLQVPPRCPVPSF 427 L + PT+ L + VP + Sbjct: 494 -----LADVAPTILNLMQIPVPAEMQGRNL 518 >5VEM-A nrPDB Length = 416 Score = 37.2 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 29/198 (14%), Positives = 51/198 (25%), Gaps = 20/198 (10%) Query: 277 QALNISVPYGPIPVD---FQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTS 333 + +N+ + Y P D +S +D ++G L+ L +L N+ + TS Sbjct: 164 EPINLGLLYWEDPDDMGHHLGPDSPLMGPVISDIDKKLGYLIQMLKKAKLWNTLNLIITS 223 Query: 334 DHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLM-- 391 DHG + + H LI P E + + Sbjct: 224 DHGMTQCSEERLIELDQYLDKDHYTLIDQSPVAAILPKEGKFDEVYEALTHAHPNLTVYK 283 Query: 392 -EPGRQSMDLVELVSLFPTLA--------------GLAGLQVPPRCPVPSFHVELCREGK 436 E + + P +A + H G Sbjct: 284 KEDVPERWHYKYNSRIQPIIAVADEGWHILQNKSDDFLLGNHGYDNALADMHPIFLAHGP 343 Query: 437 NLLKHFRFRDLEEDPYLP 454 K+F + P Sbjct: 344 AFRKNFSKEAMNSTDLYP 361 >4B56-A nrPDB Length = 820 Score = 34.9 bits (78), Expect = 0.092, Method: Composition-based stats. Identities = 22/156 (14%), Positives = 47/156 (30%), Gaps = 9/156 (5%) Query: 259 LPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSAL 318 + + + + +GP+ + + +++ +D VG L+ L Sbjct: 252 WLQLPSHERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQK--------VDRLVGMLMDGL 303 Query: 319 DDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLF 378 DL L + SDHG G ++ + + + + Y P + E + Sbjct: 304 KDLGLDKCLNLILISDHGMEQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTDVPETYY 363 Query: 379 PYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLA 414 + + + Q L P A Sbjct: 364 SFNYEALAKNLSCREPNQHFRP-YLKPFLPKRLHFA 398 >2W5W-A nrPDB Length = 375 Score = 34.5 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 24/124 (19%), Positives = 46/124 (37%), Gaps = 28/124 (22%) Query: 267 WMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYL-------DTQVGRLLSALD 319 ++ +Q L+ I + + + + SYL D +G L+ Sbjct: 230 FLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAK 289 Query: 320 DLQLANSTIIAFTSDH---GWALG----EHGEWAKYSNFDV-----------ATHVPLIF 361 +T++ TSDH G+ L + + ++YS++ AT +P+ Sbjct: 290 KDG---NTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFA 346 Query: 362 YVPG 365 Y PG Sbjct: 347 YGPG 350 >1T0O-A nrPDB Length = 417 Score = 33.0 bits (73), Expect = 0.40, Method: Composition-based stats. Identities = 21/193 (10%), Positives = 49/193 (25%), Gaps = 22/193 (11%) Query: 93 TGRRPDTTRLYDFNSYWRV------HAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHT 146 TG+ P +N+Y + + + GY +++ + Sbjct: 8 TGKVPS-LGWNSWNAYHCDIDESKFLSAAELIVSSGLLDAGYNYVNIDDCWSMKDGRVDG 66 Query: 147 DDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAI 206 +P + FP + G +++ P + A Sbjct: 67 HIAPNATRFPD---GIDGLAKKVHALGLKLGIYSTAGTAT-CAGYPASLGYEDV---DAA 119 Query: 207 QLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNP 266 + + Y ++P + E+ + + P+ L P P Sbjct: 120 DFADWGVD-------YLKYDNCNVPSDWQDEYVAC-NPDFVKTGPNGTCTTALDPTLAPP 171 Query: 267 WMDIRQREDVQAL 279 D + + Sbjct: 172 GYDWSTSKSAERF 184 >3CL7-A nrPDB Length = 308 Score = 32.6 bits (72), Expect = 0.47, Method: Composition-based stats. Identities = 16/50 (32%), Positives = 25/50 (50%), Gaps = 1/50 (2%) Query: 468 RPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNP-DEFLANFSD 516 D+P W + P+ K ++ Y++ T D R+T GFN D+F D Sbjct: 189 YDDDLPYWEPNNPTGKPHLVIPYTLDTNDMRFTQVQGFNKGDDFFEYLKD 238 >3IGZ-B nrPDB Length = 561 Score = 32.2 bits (71), Expect = 0.61, Method: Composition-based stats. Identities = 39/272 (14%), Positives = 77/272 (28%), Gaps = 26/272 (9%) Query: 158 YHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTL-PDKQSTEQAIQLLEKMKT-- 214 ++ N +A ++ L +P L P + T + + L Sbjct: 290 TRAFEDEDFNKFDRVRVPKVRYAGMMRYDGDLGIPNNFLVPPPKLTRVSEEYLCGSGLNI 349 Query: 215 ---SASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIR 271 S + F V Y + + + E P V P + + Sbjct: 350 FACSETQKFGHVTY---FWNGNRSGKIDEKH--ETFKEVPSDRVQFNEKPRMQSAAITEA 404 Query: 272 QREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAF 331 E +++ +V P A+++ + V L+ L D + + + Sbjct: 405 AIEALKSGMYNVVRINFPNGDMVGHTGDLKATITGV-EAVDESLAKLKDAVDSVNGVYIV 463 Query: 332 TSDHG--WALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQ 389 T+DHG + + + K D +V + + G L P + Sbjct: 464 TADHGNSDDMAQRDKKGK-PMKDGNGNVLPLTSHTLSPVPVFIGGAGLDPRVAMRTDLPA 522 Query: 390 LMEPGRQSMDLVELVSLFPTLAGLAGLQVPPR 421 L ++ T L G + P Sbjct: 523 A-----------GLANVTATFINLLGFEAPED 543 >3WBH-A nrPDB Length = 527 Score = 31.8 bits (70), Expect = 0.85, Method: Composition-based stats. Identities = 40/330 (12%), Positives = 86/330 (26%), Gaps = 48/330 (14%) Query: 35 DALNVLLIIVDDLRPS----LGCYGDK------LVRSPNIDQLASHSLL-FQ-----NAF 78 + NV+L+I D + P L Y ++ QLA ++ F +A Sbjct: 31 EVKNVILMIGDGMGPQQVGLLETYANQAPDSIYDGEPTAFHQLAKEGVVGFSLTHPEDAV 90 Query: 79 AQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGN--FSTIPQYFKENGYVTMSVGKV 136 + C+ + + +Y + + A T+ + + G T V Sbjct: 91 VVDSACSAT---------QLASGIYSGSEVIGIDAEGNPVETVLELAQARGKATGLVSDT 141 Query: 137 --FHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEG 194 H ++ S + + E G H + +V Sbjct: 142 RLTHATPAAFAAHQPHRSL---ENEIAVDMLEVGPDVMLSGGLRHWVPQSASEDAEVTSL 198 Query: 195 TLPDKQSTEQAI---QLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAP 251 + + LL + + + + + + L+ + Sbjct: 199 MDGAYEPASKRQDDRNLLAEAVEKGY----GLAFSREQLEADQSDKLLGLFANSGMADGI 254 Query: 252 DPEVPDGLPPVAYNPWMDIRQ------REDVQALNISVPYGPIPVDFQRKIRQSYFASVS 305 + ++ Q +D + V G I + + Sbjct: 255 EYRNTRDDADRREPTLHEMTQAALNRLEQDEDGFFLMVEGGQIDWAGHSNDAGTMLNEMV 314 Query: 306 YLDTQVGRLLSALDDLQLANSTIIAFTSDH 335 + V + T+I T+DH Sbjct: 315 KFEEAVQGVYDWAKGR---EDTVILVTADH 341 >5NMX-A nrPDB Length = 425 Score = 31.4 bits (69), Expect = 0.92, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 30/81 (37%), Gaps = 3/81 (3%) Query: 113 AGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCR 172 + T +Y K+ G+ M + H G + N+TD++ S S Y+N Sbjct: 10 GPSGLTAARYLKQAGFEVMVFERYHHVGGTWNYTDETW--MSEDGRPVYSSMYQNLFVNL 67 Query: 173 GPDGELHAN-LLCPVDVLDVP 192 + + ++ VP Sbjct: 68 PKELMAFPDFPFHDIEGSYVP 88 >5FL8-q nrPDB Length = 515 Score = 31.4 bits (69), Expect = 0.95, Method: Composition-based stats. Identities = 17/146 (11%), Positives = 45/146 (30%), Gaps = 14/146 (9%) Query: 238 FQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIR 297 + ++ ++ +T + G + R A + + Sbjct: 123 PRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTL 182 Query: 298 QSYFASVSYLDTQV-GRLLSALDDLQLANSTIIAFTSDHGWALGE----HGEWAKYSNFD 352 + ++ V + G +++ ++TI + G LG+ H +W +++ Sbjct: 183 KGHYNWVLCVSWSPDGEVIA----TGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWE 238 Query: 353 VATHVPLIFYVPGRTASLPEAGEKLF 378 P+ PG L + + Sbjct: 239 -----PIHLVKPGSKPRLASSSKDGT 259 >5OLB-A nrPDB Length = 844 Score = 31.4 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 17/33 (51%) Query: 304 VSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG 336 + +D VG+L+ L L+L + F DHG Sbjct: 297 LREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHG 329 >5MHP-A nrPDB Length = 871 Score = 30.7 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 17/33 (51%) Query: 304 VSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG 336 + +D VG+L+ L L+L + F DHG Sbjct: 329 LREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHG 361 >2MLZ-B nrPDB Length = 114 Score = 30.7 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 9/39 (23%), Positives = 13/39 (33%), Gaps = 3/39 (7%) Query: 298 QSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG 336 LD V R L +T++ T+DH Sbjct: 1 HMQIGETVDLDEAVQRALEFAKKEG---NTLVIVTADHA 36 >3WDG-A nrPDB Length = 226 Score = 30.3 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 11/54 (20%), Positives = 21/54 (38%), Gaps = 6/54 (11%) Query: 23 ALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQN 76 L Q N+ L + +L +GC + ++P++ A +L N Sbjct: 69 GLAFSVQPNAKFPPS--LRNMYKELADDIGC----VRQTPHLQDWAREGVLLLN 116 >4LJ8-A nrPDB Length = 339 Score = 30.3 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 16/88 (18%), Positives = 29/88 (32%), Gaps = 8/88 (9%) Query: 267 WMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYL-DTQVGRLLSALDDLQLAN 325 ++ + + PY I D K F + + D GRL + Sbjct: 128 YVGYEEGGQLTEAVRRRPYSVILFDEIEKAHPDVFNILLQILDD--GRLTDSHGRTVDFR 185 Query: 326 STIIAFTSDHG-----WALGEHGEWAKY 348 +T+I TS+ G L + + + Sbjct: 186 NTVIILTSNLGSPLILEGLQKGWPYERI 213 >1QVR-A nrPDB Length = 854 Score = 30.3 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 16/88 (18%), Positives = 29/88 (32%), Gaps = 8/88 (9%) Query: 267 WMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYL-DTQVGRLLSALDDLQLAN 325 ++ + + PY I D K F + + D GRL + Sbjct: 643 YVGYEEGGQLTEAVRRRPYSVILFDEIEKAHPDVFNILLQILDD--GRLTDSHGRTVDFR 700 Query: 326 STIIAFTSDHG-----WALGEHGEWAKY 348 +T+I TS+ G L + + + Sbjct: 701 NTVIILTSNLGSPLILEGLQKGWPYERI 728 >1Z7A-A nrPDB Length = 308 Score = 29.1 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 16/55 (29%), Positives = 24/55 (43%), Gaps = 1/55 (1%) Query: 463 YSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDE-FLANFSD 516 Y D+P W+ + K ++ Y++ T D R+T GFN E F D Sbjct: 184 YDSDTYDDDLPYWDPASTAEKPHLVIPYTLDTNDMRFTQVQGFNNGEQFFQYLKD 238 >3UER-A nrPDB Length = 655 Score = 28.4 bits (61), Expect = 8.6, Method: Composition-based stats. Identities = 12/54 (22%), Positives = 30/54 (55%) Query: 426 SFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDK 479 +F + L R G++L + R ++ LPG E++ ++ + RP+++ + + + Sbjct: 31 TFLLRLERYGEDLWESLRAVYGDQVRALPGRLLEVMLHAYHARPAELRRLDEAR 84 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.305 0.112 0.286 Lambda K H 0.267 0.0344 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,946,546 Number of Sequences: 36641 Number of extensions: 735105 Number of successful extensions: 2012 Number of sequences better than 10.0: 60 Number of HSP's better than 10.0 without gapping: 66 Number of HSP's successfully gapped in prelim test: 34 Number of HSP's that attempted gapping in prelim test: 1774 Number of HSP's gapped (non-prelim): 150 length of query: 550 length of database: 10,336,785 effective HSP length: 102 effective length of query: 448 effective length of database: 6,599,403 effective search space: 2956532544 effective search space used: 2956532544 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.4 bits)