BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P21954 (428 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2QFY-A nrPDB 855 0.0 6BL1-B nrPDB 552 e-158 3US8-A nrPDB 536 e-153 5I96-A nrPDB 530 e-151 4HCX-A nrPDB 519 e-147 1ZOR-A nrPDB 458 e-129 4AOY-A nrPDB 456 e-129 2UXQ-A nrPDB 410 e-115 2D1C-A nrPDB 54 2e-07 1A05-A nrPDB 52 7e-07 3U1H-A nrPDB 51 1e-06 1V5B-A nrPDB 47 1e-05 2E5M-A nrPDB 47 2e-05 1CM7-A nrPDB 44 2e-04 5YVT-A nrPDB 42 6e-04 6C0E-A nrPDB 42 7e-04 1CNZ-A nrPDB 41 8e-04 2IV0-A nrPDB 39 0.005 3TY3-A nrPDB 38 0.009 3VMK-A nrPDB 37 0.012 3VML-A nrPDB 37 0.014 1XAD-A nrPDB 37 0.018 1WPW-A nrPDB 37 0.019 1IDM-A nrPDB 37 0.020 5M2E-A nrPDB 35 0.065 3VMJ-A nrPDB 35 0.074 4IWH-A nrPDB 35 0.088 4Y1P-A nrPDB 34 0.10 2G4O-A nrPDB 34 0.14 3FMX-X nrPDB 32 0.47 4N13-A nrPDB 31 1.0 1AI3-A nrPDB 31 1.2 3ASJ-A nrPDB 31 1.3 1XR6-A nrPDB 29 3.7 6DJL-B nrPDB 29 4.4 6IXF-A nrPDB 29 4.5 1VLC-A nrPDB 29 4.6 3DMS-A nrPDB 28 6.7 5K0Y-T nrPDB 28 6.9 2D4V-A nrPDB 28 7.6 1KQ3-A nrPDB 28 7.8 5EQT-A nrPDB 28 8.2 >2QFY-A nrPDB Length = 427 Score = 855 bits (2210), Expect = 0.0, Method: Compositional matrix adjust. Identities = 413/413 (100%), Positives = 413/413 (100%) Query: 16 AFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQD 75 AFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQD Sbjct: 15 AFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQD 74 Query: 76 AAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPR 135 AAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPR Sbjct: 75 AAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPR 134 Query: 136 LVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGV 195 LVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGV Sbjct: 135 LVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGV 194 Query: 196 AMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSK 255 AMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSK Sbjct: 195 AMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSK 254 Query: 256 FEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTP 315 FEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTP Sbjct: 255 FEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTP 314 Query: 316 DGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANI 375 DGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANI Sbjct: 315 DGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANI 374 Query: 376 LESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKSIE 428 LESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKSIE Sbjct: 375 LESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKSIE 427 >6BL1-B nrPDB Length = 425 Score = 552 bits (1423), Expect = e-158, Method: Compositional matrix adjust. Identities = 269/401 (67%), Positives = 323/401 (80%), Gaps = 9/401 (2%) Query: 26 VVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGV 85 VVE+ GDEMTRIIW+ IK+KLI PY+++DL YDL +E+RDAT+D++T+DAAEAIKK+ V Sbjct: 10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNV 69 Query: 86 GIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVPRWEKPII 145 G+KCATITPDE RV+EF L +MWKSPNGTIRNILGGTVFRE I+ IPRLV W KPII Sbjct: 70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPII 129 Query: 146 IGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYK-GSGVAMAMYNTDE 204 IGRHA+GDQY+ATD ++PGPG +E+ Y PSD T Q T V++++ G GVAM MYN D+ Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGT--QKVTYLVHNFEEGGGVAMGMYNQDK 187 Query: 205 SIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYE 264 SIE FAHSSF++A+ K L+LSTKNTILKKYDGRFKDIFQE+Y+ QYKS+FE I YE Sbjct: 188 SIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYE 247 Query: 265 HRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEA 324 HRLIDDMVAQ +KS+GGFI A KNYDGDVQSD VAQG+GSLG+MTS+LV PDGKT E+EA Sbjct: 248 HRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEA 307 Query: 325 AHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTV 384 AHGTVTRHYR YQKG+ETSTN IASIFAW+RGL R +LDN L FAN LE ++ T+ Sbjct: 308 AHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETI 367 Query: 385 QQDGIMTKDLALAC----GNNERSAYVTTEEFLDAVEKRLQ 421 + G MTKDLA AC N +RS Y+ T EF+D + + L+ Sbjct: 368 EA-GFMTKDLA-ACIKGLPNVQRSDYLNTFEFMDKLGENLK 406 >3US8-A nrPDB Length = 427 Score = 536 bits (1381), Expect = e-153, Method: Compositional matrix adjust. Identities = 259/409 (63%), Positives = 318/409 (77%), Gaps = 6/409 (1%) Query: 18 SKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAA 77 +KIKV PVVELDGDEMTRIIW IK KLI PYLD+DL+YYDL VE+RDAT D++T DAA Sbjct: 25 AKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLDLEYYDLGVENRDATDDQVTIDAA 84 Query: 78 EAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLV 137 AIKK+GVG+KCATITPDE RV+EF L KMWKSPNGTIRNILGG +FREPI+ +PRLV Sbjct: 85 NAIKKHGVGVKCATITPDEGRVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLV 144 Query: 138 PRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAM 197 P W KPII+GRHA GDQY+ATD PG G L + + D T + VYD G+GVA+ Sbjct: 145 PGWTKPIIVGRHAFGDQYRATDFKFPGKGKLSIKFVGEDGQTIEHD---VYDAPGAGVAL 201 Query: 198 AMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFE 257 AMYN DESI FA +SF + +K+ ++LSTKNTILK YDGRFKDIFQ+V++ ++ ++F+ Sbjct: 202 AMYNLDESITEFARASFNYGLQRKVPVYLSTKNTILKAYDGRFKDIFQKVFDEEFAAQFK 261 Query: 258 QLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDG 317 + YEHRLIDDMVA +K GG++ A KNYDGDVQSDIVAQGFGSLGLMTS+L+TPDG Sbjct: 262 AEKLWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDG 321 Query: 318 KTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILE 377 KT E+EAAHGTVTRHYR++QKGEETSTNSIASIFAW+RGL R +LD L KF+ LE Sbjct: 322 KTVEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDGNAELAKFSETLE 381 Query: 378 SATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKS 426 ++TV+ G MTKDLAL G ++ +++T FLD +++ L+K + + Sbjct: 382 RVCVDTVES-GFMTKDLALLIGPDQ--PWLSTTGFLDKIDENLRKAMAA 427 >5I96-A nrPDB Length = 458 Score = 530 bits (1364), Expect = e-151, Method: Compositional matrix adjust. Identities = 257/417 (61%), Positives = 317/417 (76%), Gaps = 9/417 (2%) Query: 13 RLAAFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKI 72 R A +IKV +PVVE+DGDEMTRIIW IK+KLILP++D+ LKY+DL + +RD T D++ Sbjct: 37 RHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQV 96 Query: 73 TQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPR 132 T D+A A +KY V +KCATITPDEARV+EF L KMWKSPNGTI+NILGGTVFREPI+ Sbjct: 97 TIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIQNILGGTVFREPIICKN 156 Query: 133 IPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKG 192 IPRLVP W KPI IGRHAHGDQYKATD + G+ ++V+ P D + + +VY++ Sbjct: 157 IPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVK--EWEVYNFPA 214 Query: 193 SGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQY 252 GV M MYNTDESI GFAHS F+ AI KK L++STKNTILK YDGRFKDIFQE+++ Y Sbjct: 215 GGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHY 274 Query: 253 KSKFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSIL 312 K+ F++ I YEHRLIDDMVAQ++KS GGF+ A KNYDGDVQSDI+AQGFGSLGLMTS+L Sbjct: 275 KTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVL 334 Query: 313 VTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKF 372 V PDGKT E+EAAHGTVTRHYR++QKG TSTN IASIFAW+RGL RG+LD L +F Sbjct: 335 VCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRF 394 Query: 373 ANILESATLNTVQQDGIMTKDLALACGNNERSA-----YVTTEEFLDAVEKRLQKEI 424 A +LE + TV+ G MTKDLA C + + ++ T +FLD ++ L + + Sbjct: 395 AQMLEKVCVETVES-GAMTKDLA-GCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449 >4HCX-A nrPDB Length = 409 Score = 519 bits (1336), Expect = e-147, Method: Compositional matrix adjust. Identities = 253/408 (62%), Positives = 310/408 (75%), Gaps = 4/408 (0%) Query: 19 KIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAE 78 KIKV PVVELDGDEMTR+IW IK LILPYLD+ L YYDL +E RDAT D++T DAA Sbjct: 6 KIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDYYDLGIEHRDATDDQVTIDAAY 65 Query: 79 AIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVP 138 AIKK+GVG+KCATITPDEARV+EFNL KMW SPNGTIRNILGGT+FREPIVI +PRLVP Sbjct: 66 AIKKHGVGVKCATITPDEARVEEFNLKKMWLSPNGTIRNILGGTIFREPIVISNVPRLVP 125 Query: 139 RWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMA 198 W KPI+IGRHA GDQY+AT+ + PG++ L + P+D + + G GV + Sbjct: 126 GWTKPIVIGRHAFGDQYRATNFKVDQPGTVTLTFTPADGSAPIVHEMVSIPEDG-GVVLG 184 Query: 199 MYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQ 258 MYN ESI FA +SF ++ K ++LSTKNTILK YDG FKD F+ VYE ++K++FE Sbjct: 185 MYNFKESIRDFARASFSYGLNAKWPVYLSTKNTILKAYDGMFKDEFERVYEEEFKAQFEA 244 Query: 259 LGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGK 318 G+ YEHRLIDDMVA +K +GG++ A KNYDGDVQSD VAQG+GSLGLMTS+L+T DGK Sbjct: 245 AGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTADGK 304 Query: 319 TFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILES 378 T E+EAAHGTVTRHYR+YQ G+ TSTN IASIFAW+RGL RG+LD TP + FA+ LES Sbjct: 305 TVEAEAAHGTVTRHYRQYQAGKPTSTNPIASIFAWTRGLQHRGKLDGTPEVIDFAHKLES 364 Query: 379 ATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKS 426 + TV+ G MTKDLA+ G + ++ +EEFLDA+ L+KE+ + Sbjct: 365 VVIATVES-GKMTKDLAILIGPEQD--WLNSEEFLDAIADNLEKELAN 409 >1ZOR-A nrPDB Length = 399 Score = 458 bits (1178), Expect = e-129, Method: Compositional matrix adjust. Identities = 223/406 (54%), Positives = 297/406 (73%), Gaps = 9/406 (2%) Query: 17 FSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDA 76 K+KVK P+VELDGDEM R++W IK+KLILPYLD+ L Y+DL ++ RD T D+IT +A Sbjct: 1 MEKVKVKNPIVELDGDEMARVMWKMIKEKLILPYLDIQLVYFDLGIKKRDETDDQITIEA 60 Query: 77 AEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRL 136 A+AIKKYGVG+KCATITPD RVKE+NL K WKSPN TIR L GTVFR+PI++ +P L Sbjct: 61 AKAIKKYGVGVKCATITPDAERVKEYNLKKAWKSPNATIRAYLDGTVFRKPIMVKNVPPL 120 Query: 137 VPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVA 196 V RW+KPIIIGRHA+GD Y A + + GP +ELV + + +TL V+ ++G+GV Sbjct: 121 VKRWKKPIIIGRHAYGDIYNAVEAKVEGPAEVELVVR-----NKENKTLLVHKFEGNGVV 175 Query: 197 MAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKF 256 MAM+N ++SI FA S AI +K++++ +TK+TI K Y FKDIFQE + + K + Sbjct: 176 MAMHNLEKSIRSFAQSCINYAISEKVDIWFATKDTISKVYHAYFKDIFQEEVDKR-KEEL 234 Query: 257 EQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPD 316 E+ G++Y + LIDD AQ+++S+GG + A NY+GD+ SD++A GFGSLGLMTS+LV+PD Sbjct: 235 EKAGVNYRYMLIDDAAAQILRSEGGMLWACMNYEGDIMSDMIASGFGSLGLMTSVLVSPD 294 Query: 317 GKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANIL 376 G +E EAAHGTV RHY +Y KGE+TSTN ASIFAW+ + KRGELD TP +C+FA+ L Sbjct: 295 G-VYEFEAAHGTVRRHYYRYLKGEKTSTNPTASIFAWTGAIRKRGELDGTPEVCEFADKL 353 Query: 377 ESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQK 422 E A +NT++ G++TKDL YVT EEF+D V+K L+K Sbjct: 354 EKAVINTIES-GVITKDLQ-PFTEPPIDKYVTLEEFIDEVKKNLEK 397 >4AOY-A nrPDB Length = 402 Score = 456 bits (1173), Expect = e-129, Method: Compositional matrix adjust. Identities = 227/404 (56%), Positives = 294/404 (72%), Gaps = 6/404 (1%) Query: 18 SKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAA 77 SKIK+K P+VE+DGDEMTRIIW IK+ L+ PY++++ +YYDL +E+RD T D++T DAA Sbjct: 2 SKIKMKVPLVEMDGDEMTRIIWRLIKENLLEPYIELNTEYYDLGLENRDKTEDQVTIDAA 61 Query: 78 EAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLV 137 AI+KYGVG+KCATITP+ RV+E+NL KMWKSPNGTIR IL GTVFR PIV+ I V Sbjct: 62 RAIQKYGVGVKCATITPNAQRVEEYNLKKMWKSPNGTIRAILDGTVFRAPIVVNSIKPFV 121 Query: 138 PRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAM 197 W+KPI I RHA+GD YK + +P G ELV+ + ++ QT ++++ G GV M Sbjct: 122 KGWKKPISIARHAYGDVYKNVEYYVPSAGKAELVFTSENGEVSR-QT--IHEFDGPGVIM 178 Query: 198 AMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFE 257 M+NTD+SI FA + F A+D +L+ STK+TI K YD RFKDIFQE+YE +YK KFE Sbjct: 179 GMHNTDKSIRSFARACFNYALDMNQDLWFSTKDTISKTYDHRFKDIFQEIYENEYKEKFE 238 Query: 258 QLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDG 317 + Y + LIDD VA++I+S+GG + A KNYDGDV SD+VA FGSL +MTS+LV+PDG Sbjct: 239 AKNLQYFYTLIDDAVARIIRSEGGMVWACKNYDGDVMSDMVASAFGSLAMMTSVLVSPDG 298 Query: 318 KTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILE 377 K +E EAAHGTVTRHY K+ KGEETSTNS+A+IFAW+ L KRGELD L FA LE Sbjct: 299 K-YEFEAAHGTVTRHYYKHLKGEETSTNSMATIFAWTGALKKRGELDGIKELVDFATKLE 357 Query: 378 SATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQ 421 A++ T+ ++G+MTKDLA E+ V TE+FL + K + Sbjct: 358 QASVQTI-ENGVMTKDLASLSEVPEKKI-VNTEDFLKEIRKTFE 399 >2UXQ-A nrPDB Length = 402 Score = 410 bits (1053), Expect = e-115, Method: Compositional matrix adjust. Identities = 204/406 (50%), Positives = 285/406 (70%), Gaps = 10/406 (2%) Query: 19 KIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAE 78 KI++K P+VELDGDEMTR++W IK KL+LP++D+ +YYDL +E RD T+D+IT DAAE Sbjct: 2 KIQMKTPLVELDGDEMTRVLWPLIKDKLLLPFIDLQTEYYDLGIEERDRTNDQITIDAAE 61 Query: 79 AIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVP 138 AIKKYGVG+K ATITP++ RV+E+ L + WKSPN T+R +L GTVFR+PI++ I V Sbjct: 62 AIKKYGVGVKNATITPNQDRVEEYGLKEQWKSPNATVRAMLDGTVFRKPIMVKNIKPSVR 121 Query: 139 RWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMA 198 W+KPI++GRHA+GD YK + G LE+V + + ++V + + Sbjct: 122 SWQKPIVVGRHAYGDFYKNAEIFAEAGGKLEIVVTDKNGKETRQTIMEVDE---PAIVQG 178 Query: 199 MYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQ 258 ++NT SI FA + F+ ++D+K++ + +TK+TI K+YD RFK IF+E++ +YK KF Sbjct: 179 IHNTVASIGHFARACFEYSLDQKIDCWFATKDTISKQYDQRFKIIFEEIFAQEYKEKFAA 238 Query: 259 LGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGK 318 GI Y + LIDD+VA+M+K++GG + A KNYDGDV SD+VA FGSL +M+S+LV+P G Sbjct: 239 AGIEYFYTLIDDVVARMMKTEGGMLWACKNYDGDVMSDMVASAFGSLAMMSSVLVSPYG- 297 Query: 319 TFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILES 378 FE EAAHGTV RHY ++ KGE TSTN +A I+AW+ L KRGELD TP LC F + LE+ Sbjct: 298 YFEYEAAHGTVQRHYYQHLKGERTSTNPVALIYAWTGALRKRGELDGTPDLCAFCDSLEA 357 Query: 379 ATLNTVQQDGIMTKDLALACGNNERSA--YVTTEEFLDAVEKRLQK 422 T+ ++ G MT DLA C E +A + + EF+D + KRLQ+ Sbjct: 358 ITIECIES-GYMTGDLARIC---EPAAIKVLDSIEFIDELGKRLQQ 399 >2D1C-A nrPDB Length = 496 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 85/361 (23%), Positives = 148/361 (40%), Gaps = 68/361 (18%) Query: 65 RDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVF 124 R + + Q+ E+I+K V +K TP + KS N T+R + Sbjct: 62 RRGIASGVPQETIESIRKTRVVLKGPLETP---------VGYGEKSANVTLRKLFETYAN 112 Query: 125 REPIV-IPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQ 183 P+ P +P +++ R D Y + + P+ AQ Sbjct: 113 VRPVREFPNVPTPYAGRGIDLVVVRENVEDLYAGIEHM-------------QTPSVAQ-- 157 Query: 184 TLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLA-IDKKLNLFLSTKNTILKKYDGRFKD 242 TLK+ +KGS E I FA F+LA + + + +TK+ I+K +G K Sbjct: 158 TLKLISWKGS----------EKIVRFA---FELARAEGRKKVHCATKSNIMKLAEGTLKR 204 Query: 243 IFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQG 301 F++V AQ E + H ++D+ Q++K F ++ N +GD+ SD+ + Sbjct: 205 AFEQV--AQEYPDIEAV-----HIIVDNAAHQLVKRPEQFEVIVTTNMNGDILSDLTSGL 257 Query: 302 FGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRG 361 G LG S + + F EA HG+ ++ K N A + + L Sbjct: 258 IGGLGFAPSANIGNEVAIF--EAVHGSAPKYAGK------NVINPTAVLLSAVMMLRYLE 309 Query: 362 ELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQ 421 E A+++E+A L T+++ ++T D+ +R A T E+ +A+ + L Sbjct: 310 EFAT-------ADLIENALLYTLEEGRVLTGDVV----GYDRGAKTT--EYTEAIIQNLG 356 Query: 422 K 422 K Sbjct: 357 K 357 >1A05-A nrPDB Length = 358 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 95/216 (43%), Gaps = 25/216 (11%) Query: 181 QPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRF 240 QP+ L+V D K G +Y+ DE I AH +F+ A ++ L K +L+ + Sbjct: 143 QPRGLEVIDGKRRGFNTMVYDEDE-IRRIAHVAFRAAQGRRKQLCSVDKANVLETTR-LW 200 Query: 241 KDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVA 299 +++ EV Y + H +D+ Q+I++ F ++ N GD+ SD + Sbjct: 201 REVVTEVAR-DYPD------VRLSHMYVDNAAMQLIRAPAQFDVLLTGNMFGDILSDEAS 253 Query: 300 QGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLK 359 Q GS+G++ P E A + + H + N +A+I S ++ Sbjct: 254 QLTGSIGML------PSASLGEGRAMYEPI--HGSAPDIAGQDKANPLATIL--SVAMML 303 Query: 360 RGELDNTPALCKFANILESATLNTVQQDGIMTKDLA 395 R L+ P +A +E+A + Q G+ T D+A Sbjct: 304 RHSLNAEP----WAQRVEAAVQRVLDQ-GLRTADIA 334 >3U1H-A nrPDB Length = 390 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 59/226 (26%), Positives = 98/226 (43%), Gaps = 28/226 (12%) Query: 202 TDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGI 261 T E IE +F+LA+ +K + K +L+ +++EV E K E + Sbjct: 184 TREEIERIIRKAFELALTRKKKVTSVDKANVLES-----SRLWREVAEEVAK---EYPDV 235 Query: 262 HYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTF 320 EH L+D+ Q+I++ F ++ +N GD+ SD + GSLG++ S ++ DG Sbjct: 236 ELEHMLVDNAAMQLIRNPRQFDVIVTENMFGDILSDEASMITGSLGMLPSASLSTDGLGL 295 Query: 321 ESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESAT 380 E HG+ K + S A + +S GL + A +E A Sbjct: 296 -YEPVHGSAPDIAGKGIANPLATILSAAMMLRYSFGLEEE------------AKAIEKA- 341 Query: 381 LNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKS 426 + V +G T D+A G YV+T E D V+ + E+ + Sbjct: 342 VEKVLAEGYRTADIAKPGGK-----YVSTTEMTDEVKAAVVDELAT 382 >1V5B-A nrPDB Length = 366 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 58/222 (26%), Positives = 97/222 (43%), Gaps = 28/222 (12%) Query: 202 TDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGI 261 T E IE +F+LA ++ L K +L+ +++E+ E K K+ + Sbjct: 163 TREEIERIIEKAFQLAQIRRKKLASVDKANVLES-----SRMWREIAEETAK-KYPD--V 214 Query: 262 HYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTF 320 H L+D Q+I + G F ++ +N GD+ SD+ + GSLG++ S + D + Sbjct: 215 ELSHMLVDSTAMQLIANPGQFDVIVTENMFGDILSDLASVITGSLGMLPSASLRSD-RFG 273 Query: 321 ESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESAT 380 E HG+ + + + S A + +S GL K A +E A Sbjct: 274 MYEPVHGSAPDIAGQGKANPLGTVLSAALMLRYSFGLEKE------------AAAIEKA- 320 Query: 381 LNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQK 422 ++ V QDG T DL +A G V+T E D + ++L Sbjct: 321 VDDVLQDGYCTGDLQVANGK-----VVSTIELTDRLIEKLNN 357 >2E5M-A nrPDB Length = 409 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 82/355 (23%), Positives = 147/355 (41%), Gaps = 64/355 (18%) Query: 68 TSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREP 127 +D+ ++ E + KY V +K TP + K WKS N IR +L P Sbjct: 76 VNDRFPKETQEMLLKYRVVLKGPLETP---------IGKGWKSVNVAIRLMLDLYANIRP 126 Query: 128 IVIPRIPRLVPRWEKPI--------IIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTT 179 + + + E P+ II R D Y+ + P + E K D Sbjct: 127 V------KYIEGLESPLKHPEKVDMIIFRENTDDLYRGIEY----PFNSEEAKKIRDFLR 176 Query: 180 AQPQTLKVYDYKGSGV-AMAMYNTDESIEGFAHSSFKLAID-KKLNLFLSTKNTILKKYD 237 + + +++ D G G+ M+ Y T + + AI+ K+ + + K ++K + Sbjct: 177 KELK-VEIEDDTGIGIKVMSKYKTQR----ITRLAIQYAIEHKRKKVTIMHKGNVMKYTE 231 Query: 238 GRFKDIFQEVYEAQYK-----------SKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMA 285 G F++ EV +Y+ K +Q I R+ D+M Q+I + I+ Sbjct: 232 GAFREWAYEVALKEYRDFIVTEEEINQGKPDQGKIILNDRIADNMFQQIIIRPEEYDIIL 291 Query: 286 LKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTN 345 N +GD SD G++G++ + +G F EA HGT ++ + Sbjct: 292 APNVNGDYISDAAGALIGNIGMLGGANIGDEGGMF--EAIHGTAPKY----------AGK 339 Query: 346 SIASIFAWSRGLLKRGELD-NTPALCKFANILESATLNTVQQDGIMTKDLALACG 399 ++A+ G++K GEL + A+++E A +N +D +T+D+A G Sbjct: 340 NVAN----PTGIIKAGELMLRWMGWNEAADLIEKA-INMAIRDKKVTQDIARFMG 389 >1CM7-A nrPDB Length = 363 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/165 (29%), Positives = 71/165 (43%), Gaps = 21/165 (12%) Query: 261 IHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKT 319 + H ID+ Q+IK F ++ N GD+ SD A GS+G++ S + G Sbjct: 219 VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG 278 Query: 320 FESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESA 379 E A G+ K N IA I S LL R LD A C +E A Sbjct: 279 L-YEPAGGSAPDIAGK------NIANPIAQIL--SLALLLRYSLDADDAACA----IERA 325 Query: 380 TLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEI 424 +N ++GI T DLA +A V+T+E D + + + + + Sbjct: 326 -INRALEEGIRTGDLARG------AAAVSTDEMGDIIARYVAEGV 363 >5YVT-A nrPDB Length = 339 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 49/194 (25%), Positives = 80/194 (41%), Gaps = 28/194 (14%) Query: 219 DKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKS 278 + + N+ K I++ DG F +EV E+ KF ++ +D + M++ Sbjct: 163 NHRSNVTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEM-------YLDTVCLNMVQD 215 Query: 279 KGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDG-KTFESEAAHGTVTRHYRKY 336 F ++ + N GD+ SD+ A G LG+ S + +G FES HGT K Sbjct: 216 PSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFES--VHGTAPDIAGK- 272 Query: 337 QKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLAL 396 N A + + L G D+ A +E+A T++ +TKDL Sbjct: 273 -----DMANPTALLLSAVMMLRHMGLFDH-------AARIEAACFATIKDGKSLTKDL-- 318 Query: 397 ACGNNERSAYVTTE 410 G N + + T E Sbjct: 319 --GGNAKCSDFTEE 330 >6C0E-A nrPDB Length = 419 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 61/278 (21%), Positives = 115/278 (41%), Gaps = 33/278 (11%) Query: 72 ITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPI-VI 130 + ++ +A+KKY V IK TP ++ N+ IR + V PI Sbjct: 87 LPKETLDAMKKYVVSIKGPLTTPVGGGIRSLNV---------AIRQDMDLYVCLRPIRYF 137 Query: 131 PRIPRLVPR-WEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYD 189 +P V W+ ++I R D Y + P + +++ + + ++ + Sbjct: 138 NGVPSPVREPWKTDMVIFRENSEDIYAGIEWQADTPEAKKVIQFLTKEMGVK--KIRFPE 195 Query: 190 YKGSGVAMAMYNTDESIEGFAHSSFKLAIDK-KLNLFLSTKNTILKKYDGRFKDIFQEVY 248 + G GV + E ++ + AID + + L K I+K +G FKD +V Sbjct: 196 HCGIGVKPV---SREGTTRLVKAAIQYAIDNDRSTVTLVHKGNIMKFTEGAFKDWGYQVA 252 Query: 249 EAQYKSKFEQLGIHYEHR--------LIDDMVAQ------MIKSKGGFIMALKNYDGDVQ 294 + +K Q G E + +I+D++A +++ + ++A N +GD Sbjct: 253 RDSFGAKEYQGGPWMEFKNPKTGKQIIINDVIADAFLQQILLRPEDYSVIATLNLNGDYI 312 Query: 295 SDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRH 332 SD +A G +G+ ++ F EA HGT ++ Sbjct: 313 SDALAAQVGGIGIAPGANISDQMAVF--EATHGTAPKY 348 >1CNZ-A nrPDB Length = 363 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 47/165 (28%), Positives = 71/165 (43%), Gaps = 21/165 (12%) Query: 261 IHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKT 319 + H ID+ Q+IK F ++ N GD+ SD A GS+G++ S + G Sbjct: 219 VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG 278 Query: 320 FESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESA 379 E A G+ K N IA I S LL R LD A A +E A Sbjct: 279 L-YEPAGGSAPDIAGK------NIANPIAQIL--SLALLLRYSLDANDA----ATAIEQA 325 Query: 380 TLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEI 424 +N ++G+ T DLA +A V+T+E D + + + + + Sbjct: 326 -INRALEEGVRTGDLARG------AAAVSTDEMGDIIARYVAEGV 363 >2IV0-A nrPDB Length = 412 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 35/218 (16%) Query: 219 DKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQ--------------YKSKFEQLGIHYE 264 + + ++ L K I+K +G F+D EV + + Y K + I + Sbjct: 213 NNRKSVTLVHKGNIMKYTEGAFRDWGYEVAKQEFGEYCITEDELWDKYGGKQPEGKIVVK 272 Query: 265 HRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESE 323 R+ D+M Q++ + ++AL N +GD SD A G LG+ + FE Sbjct: 273 DRIADNMFQQILTRTDEYDVIALPNLNGDYLSDAAAALIGGLGIAPGSNIGDGIGVFEP- 331 Query: 324 AAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNT 383 HG+ ++ + N A I + G D + + K + S+ Sbjct: 332 -VHGSAPKY------AGQNKVNPTAEILTGALMFEYIGWKDASEMIKKAVEMTISS---- 380 Query: 384 VQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQ 421 GI+T D+ G + V T EF +AV + LQ Sbjct: 381 ----GIVTYDIHRHMGGTK----VGTREFAEAVVENLQ 410 >3TY3-A nrPDB Length = 366 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 33/116 (28%), Positives = 57/116 (49%), Gaps = 13/116 (11%) Query: 217 AIDKKLNLFLSTKNTILKKYDGRFKDIFQ--EVYEAQYKSKFEQLGIHYEHRLIDDMVAQ 274 +I KK + + K+ ++ DG F++ + + + Y S I+ + +++D MV + Sbjct: 188 SIHKKPLVTIIHKSNVMSVTDGLFRESCRHAQSLDPSYAS------INVDEQIVDSMVYR 241 Query: 275 MIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTF-ESEAAHGT 328 + + F ++ N GD+ SD A GSLGL+ S V G F SE HG+ Sbjct: 242 LFREPECFDVVVAPNLYGDILSDGAASLIGSLGLVPSANV---GDNFVMSEPVHGS 294 >3VMK-A nrPDB Length = 375 Score = 37.4 bits (85), Expect = 0.012, Method: Compositional matrix adjust. Identities = 20/58 (34%), Positives = 31/58 (53%), Gaps = 1/58 (1%) Query: 261 IHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDG 317 + EH ID+ Q+++ F +M N GD+ SD +A GS+GL+ SI + G Sbjct: 228 VELEHIYIDNATMQLLRRPNEFDVMLCSNLFGDIVSDEIAMLTGSMGLLASISMNSQG 285 >3VML-A nrPDB Length = 375 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 20/58 (34%), Positives = 31/58 (53%), Gaps = 1/58 (1%) Query: 261 IHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDG 317 + EH ID+ Q+++ F +M N GD+ SD +A GS+GL+ SI + G Sbjct: 228 VELEHIYIDNATMQLLRRPNEFDVMLCSNLFGDIVSDEIAMLTGSMGLLASISMNSQG 285 >1XAD-A nrPDB Length = 345 Score = 37.0 bits (84), Expect = 0.018, Method: Compositional matrix adjust. Identities = 24/83 (28%), Positives = 41/83 (49%), Gaps = 8/83 (9%) Query: 252 YKSKFEQLGIHY-----EHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSL 305 ++ E++G Y EH+ +D M +++S F ++ N GD+ SD+ + GSL Sbjct: 195 WRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSL 254 Query: 306 GLMTSILVTPDGKTFESEAAHGT 328 GL+ S + FE HG+ Sbjct: 255 GLLPSASLGRGTPVFEP--VHGS 275 >1WPW-A nrPDB Length = 336 Score = 36.6 bits (83), Expect = 0.019, Method: Compositional matrix adjust. Identities = 55/239 (23%), Positives = 95/239 (39%), Gaps = 34/239 (14%) Query: 190 YKG------SGVAMAM-YNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKD 242 YKG GVA+ M T + E A A+ ++ + K +++ DG Sbjct: 123 YKGFEHIVSDGVAVGMKIITRFASERIAKVGLNFALRRRKKVTCVHKANVMRITDG---- 178 Query: 243 IFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQG 301 +F E + K K E Y +D A ++++ F ++ +N GD+ SD +Q Sbjct: 179 LFAEACRSVLKGKVE-----YSEMYVDAAAANLVRNPQMFDVIVTENVYGDILSDEASQI 233 Query: 302 FGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRG 361 GSLG+ S + FE HG + + N A + + S + Sbjct: 234 AGSLGIAPSANIGDKKALFEP--VHGAA------FDIAGKNIGNPTAFLLSVSMMYERMY 285 Query: 362 ELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRL 420 EL N K + LE+A ++ +T D+ GN TT++ ++ + +L Sbjct: 286 ELSNDDRYIKASRALENAIYLVYKERKALTPDVG---GN------ATTDDLINEIYNKL 335 >1IDM-A nrPDB Length = 343 Score = 36.6 bits (83), Expect = 0.020, Method: Compositional matrix adjust. Identities = 24/83 (28%), Positives = 41/83 (49%), Gaps = 8/83 (9%) Query: 252 YKSKFEQLGIHY-----EHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSL 305 ++ E++G Y EH+ +D M +++S F ++ N GD+ SD+ + GSL Sbjct: 193 WRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSL 252 Query: 306 GLMTSILVTPDGKTFESEAAHGT 328 GL+ S + FE HG+ Sbjct: 253 GLLPSASLGRGTPVFEP--VHGS 273 >5M2E-A nrPDB Length = 418 Score = 35.0 bits (79), Expect = 0.065, Method: Compositional matrix adjust. Identities = 32/146 (21%), Positives = 63/146 (43%), Gaps = 17/146 (11%) Query: 202 TDESIEGFAHSSFKLAIDK-KLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLG 260 + E + + + A+D + ++ L K I+K +G FKD EV ++ ++ G Sbjct: 204 SQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVARDEFGAELLDGG 263 Query: 261 IHYEHR-------------LIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLG 306 + + + D M+ Q++ + ++A N +GD SD +A G +G Sbjct: 264 PWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIATLNLNGDYLSDALAAEVGGIG 323 Query: 307 LMTSILVTPDGKTFESEAAHGTVTRH 332 + ++ F EA HGT ++ Sbjct: 324 IAPGANLSDSVAMF--EATHGTAPKY 347 >3VMJ-A nrPDB Length = 375 Score = 34.7 bits (78), Expect = 0.074, Method: Compositional matrix adjust. Identities = 19/58 (32%), Positives = 31/58 (53%), Gaps = 1/58 (1%) Query: 261 IHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDG 317 + EH ID+ Q+++ F +M N GD+ SD +A GS+GL++S + G Sbjct: 228 VELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSTG 285 >4IWH-A nrPDB Length = 363 Score = 34.7 bits (78), Expect = 0.088, Method: Compositional matrix adjust. Identities = 46/198 (23%), Positives = 86/198 (43%), Gaps = 23/198 (11%) Query: 199 MYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQ 258 M ++ + AH +F+ A + L K+ +L+ ++D+ +V + E Sbjct: 168 MRYSEPEVRRIAHVAFQAAQKRAKKLLSVDKSNVLETSQ-FWRDVMIDVSK-------EY 219 Query: 259 LGIHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDG 317 + H +D+ Q+ K+ F ++ N GD+ SD + GS+G++ S + + Sbjct: 220 ADVELSHMYVDNAAMQLAKAPKQFDVIVTGNMFGDILSDEASMLTGSIGMLPSASLDKNN 279 Query: 318 KTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILE 377 K E +HG+ K N +A+I S +L R L+ + A+ +E Sbjct: 280 KGL-YEPSHGSAPDIAGK------GIANPLATIL--SAAMLLRYSLNR----AEQADRIE 326 Query: 378 SATLNTVQQDGIMTKDLA 395 A + TV + G T D+A Sbjct: 327 RA-VKTVLEQGYRTGDIA 343 >4Y1P-A nrPDB Length = 337 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 27/121 (22%), Positives = 51/121 (42%), Gaps = 12/121 (9%) Query: 209 FAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLI 268 A + A+ +K + K+ +++ DG F + + V + + + Y + Sbjct: 150 IAQVALNQALRRKKKVVCVHKSNVMRITDGLFAESCRNVLKGK---------VEYSEMYV 200 Query: 269 DDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHG 327 D A ++++ F ++ +N GD+ SD Q GSLG+ S + FE HG Sbjct: 201 DAAAANLVRNPQAFDVIVTENTYGDILSDEAGQIAGSLGISPSANIGDRKSLFEP--VHG 258 Query: 328 T 328 Sbjct: 259 A 259 >2G4O-A nrPDB Length = 337 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 28/111 (25%), Positives = 47/111 (42%), Gaps = 8/111 (7%) Query: 201 NTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLG 260 NT + +F+ A ++ +L L K +L G + EV E + + Sbjct: 151 NTAFGVRRVVADAFERARRRRKHLTLVHKTNVLTFAGGLWLRTVDEVGEC-----YPDVE 205 Query: 261 IHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTS 310 + Y+H +D MI G F ++ N GD+ +D+ A G +GL S Sbjct: 206 VAYQH--VDAATIHMITDPGRFDVIVTDNLFGDIITDLAAAVCGGIGLAAS 254 >3FMX-X nrPDB Length = 364 Score = 32.0 bits (71), Expect = 0.47, Method: Compositional matrix adjust. Identities = 30/115 (26%), Positives = 50/115 (43%), Gaps = 17/115 (14%) Query: 252 YKSKFEQLGIHYEH-----RLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSL 305 + + E + HY H + ID + A+ + F ++ N GD+ SD+ G++ Sbjct: 203 WDKRTEAMAAHYPHVSWDKQHIDILCARFVLQPERFDVVVASNLFGDILSDLGPACAGTI 262 Query: 306 GLMTSILVTPDGKTFES--EAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLL 358 G+ S + P+ + F S E HG+ + K N IA I WS L+ Sbjct: 263 GIAPSANLNPE-RNFPSLFEPVHGSAPDIFGK------NIANPIAMI--WSGALM 308 >4N13-A nrPDB Length = 265 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%) Query: 56 KYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTI 115 K Y +++ SRD T ++I Q A E + Y I IT E ++ + K NG I Sbjct: 59 KIYKIAISSRDLTKEEIEQGAKETVFAYDALI---FITSPEIKITNITEENLAKILNGEI 115 Query: 116 RN 117 +N Sbjct: 116 QN 117 >1AI3-A nrPDB Length = 416 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 30/146 (20%), Positives = 65/146 (44%), Gaps = 17/146 (11%) Query: 202 TDESIEGFAHSSFKLAI-DKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLG 260 ++E + ++ + AI + + ++ L K I+K +G FKD ++ ++ + G Sbjct: 202 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGG 261 Query: 261 IHYEHR--------LIDDMVAQ------MIKSKGGFIMALKNYDGDVQSDIVAQGFGSLG 306 + + +I D++A +++ ++A N +GD SD +A G +G Sbjct: 262 PWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIG 321 Query: 307 LMTSILVTPDGKTFESEAAHGTVTRH 332 + + + F EA HGT ++ Sbjct: 322 IAPGANIGDECALF--EATHGTAPKY 345 >3ASJ-A nrPDB Length = 334 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 27/107 (25%), Positives = 46/107 (42%), Gaps = 10/107 (9%) Query: 223 NLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF 282 L ++ K +L G F D +EV + F ++ + ++D+ Q++ F Sbjct: 165 TLHIAHKANVLPLTQGLFLDTVKEVAK-----DFPL--VNVQDIIVDNCAMQLVMRPERF 217 Query: 283 -IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGT 328 ++ N GD+ SD+ A G LGL S + FE HG+ Sbjct: 218 DVIVTTNLLGDILSDLAAGLVGGLGLAPSGNIGDTTAVFEP--VHGS 262 >1XR6-A nrPDB Length = 460 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 18/48 (37%), Positives = 27/48 (56%), Gaps = 4/48 (8%) Query: 57 YYDLSVESRDATSDKITQDAA---EAIKKYGVGIKCATITPDEARVKE 101 Y + ++ RD ++K T+D + EA+ KYGV + T DE R KE Sbjct: 120 YVTMGIKKRDLINNK-TKDISRLKEALDKYGVDLPMITFLKDELRKKE 166 >6DJL-B nrPDB Length = 266 Score = 28.9 bits (63), Expect = 4.4, Method: Compositional matrix adjust. Identities = 15/41 (36%), Positives = 25/41 (60%), Gaps = 5/41 (12%) Query: 250 AQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYD 290 A+Y + EQL + +DD+ A++ +KG + MALKN + Sbjct: 217 AKYYVQLEQLK-----KTVDDLQAKLTLAKGEYKMALKNLE 252 >6IXF-A nrPDB Length = 228 Score = 28.9 bits (63), Expect = 4.5, Method: Compositional matrix adjust. Identities = 15/41 (36%), Positives = 25/41 (60%), Gaps = 5/41 (12%) Query: 250 AQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYD 290 A+Y + EQL + +DD+ A++ +KG + MALKN + Sbjct: 178 AKYYVQLEQLK-----KTVDDLQAKLTLAKGEYKMALKNLE 213 >1VLC-A nrPDB Length = 366 Score = 28.9 bits (63), Expect = 4.6, Method: Compositional matrix adjust. Identities = 50/221 (22%), Positives = 94/221 (42%), Gaps = 32/221 (14%) Query: 204 ESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGR-FKDIFQEVYEAQYKSKFEQLGIH 262 +++E A ++F++A +++ + K +L Y ++ + EV E + Sbjct: 174 KTVERIARTAFEIAKNRRKKVTSVDKANVL--YSSMLWRKVVNEVAR-------EYPDVE 224 Query: 263 YEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFE 321 H +D+ Q+I F ++ N GD+ SD A GSLGL+ S G Sbjct: 225 LTHIYVDNAAMQLILKPSQFDVILTTNMFGDILSDESAALPGSLGLLPS---ASFGDKNL 281 Query: 322 SEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATL 381 E A G+ K N IA I + + L+++ + + A +E A + Sbjct: 282 YEPAGGSAPDIAGK------NIANPIAQILSLAM------MLEHSFGMVEEARKIERA-V 328 Query: 382 NTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQK 422 V ++G T+D+A + V+T + D + K+L++ Sbjct: 329 ELVIEEGYRTRDIA-----EDPEKAVSTSQMGDLICKKLEE 364 >3DMS-A nrPDB Length = 427 Score = 28.1 bits (61), Expect = 6.7, Method: Compositional matrix adjust. Identities = 58/285 (20%), Positives = 111/285 (38%), Gaps = 41/285 (14%) Query: 72 ITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPI-VI 130 + ++ + +K+Y V IK TP ++ N+ +R L V PI Sbjct: 94 LPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNV---------ALRQELDLYVCLRPIQYF 144 Query: 131 PRIPRLVPRWEKP-IIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQ----PQTL 185 +P V EK ++I R D Y + + +++ + + PQT Sbjct: 145 KGVPSPVREPEKTNMVIFRENSEDIYAGIEWAAESEQAKKVIKFLQEEMGVKKIRFPQT- 203 Query: 186 KVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDK-KLNLFLSTKNTILKKYDGRFKDIF 244 SG+ + + E E + + AID + ++ L K I+K +G F+D Sbjct: 204 -------SGIGIKPV-SKEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTEGAFRDAG 255 Query: 245 QEVYEAQYKSKFEQLG-------------IHYEHRLIDDMVAQMIKSKGGF-IMALKNYD 290 + + ++ ++ G I + + D + Q++ + ++A N + Sbjct: 256 YALAQKEFGAELIDGGPWMKFKNPKTGNEIVVKDSIADAFLQQILLRPAEYDVIATLNLN 315 Query: 291 GDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRK 335 GD SD +A G +G+ ++ F EA HGT ++ K Sbjct: 316 GDYISDALAAQVGGIGIAPGANLSDSVAMF--EATHGTAPKYAGK 358 >5K0Y-T nrPDB Length = 329 Score = 28.1 bits (61), Expect = 6.9, Method: Compositional matrix adjust. Identities = 12/31 (38%), Positives = 16/31 (51%) Query: 303 GSLGLMTSILVTPDGKTFESEAAHGTVTRHY 333 G G + S+ PDGK++ S G V HY Sbjct: 283 GHFGPINSVAFHPDGKSYSSGGEDGYVRIHY 313 >2D4V-A nrPDB Length = 429 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 31/135 (22%), Positives = 54/135 (40%), Gaps = 29/135 (21%) Query: 221 KLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKS---------------------KFEQL 259 K ++ L K I+K +G F+D + E ++ K EQ Sbjct: 222 KPSVSLVHKGNIMKFTEGGFRDWGYALAEREFAGRVFTWRQKAAISKAEGKAAGQKAEQQ 281 Query: 260 GIHYEHRLIDDMVAQ------MIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILV 313 I +I D++A +++ + ++A N +GD SD +A G +G+ + Sbjct: 282 AIADGKLIIKDVIADNFLQQILLRPEDYSVVATLNLNGDYVSDALAAEVGGIGMAPGANL 341 Query: 314 TPDGKTFESEAAHGT 328 + F EA HGT Sbjct: 342 SDTHAIF--EATHGT 354 >1KQ3-A nrPDB Length = 376 Score = 28.1 bits (61), Expect = 7.8, Method: Compositional matrix adjust. Identities = 28/98 (28%), Positives = 42/98 (42%), Gaps = 17/98 (17%) Query: 317 GKTFES---EAAHG-----TVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPA 368 G FES AAH TV + KY GE+ + +AS+F + R ++ + Sbjct: 252 GLGFESGGLAAAHAIHNGLTVLENTHKYLHGEKVAIGVLASLFLTDK---PRKMIEEVYS 308 Query: 369 LCKFANILESATLNTVQQDGIMTKDLA----LACGNNE 402 C+ + TL + DG+ +DL AC NE Sbjct: 309 FCEEVGL--PTTLAEIGLDGVSDEDLMKVAEKACDKNE 344 >5EQT-A nrPDB Length = 257 Score = 28.1 bits (61), Expect = 8.2, Method: Compositional matrix adjust. Identities = 14/27 (51%), Positives = 18/27 (66%) Query: 402 ERSAYVTTEEFLDAVEKRLQKEIKSIE 428 ER YVT E+FL AV+K L E K ++ Sbjct: 228 ERRTYVTQEDFLKAVDKVLGNERKLLQ 254 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2QFY-A nrPDB 599 e-172 5I96-A nrPDB 581 e-166 3US8-A nrPDB 565 e-161 4HCX-A nrPDB 560 e-160 6BL1-B nrPDB 548 e-156 4AOY-A nrPDB 528 e-150 1ZOR-A nrPDB 517 e-147 2UXQ-A nrPDB 517 e-147 6C0E-A nrPDB 269 2e-72 2E5M-A nrPDB 265 2e-71 2D1C-A nrPDB 264 4e-71 5YVT-A nrPDB 213 2e-55 1A05-A nrPDB 205 3e-53 3U1H-A nrPDB 203 1e-52 1V5B-A nrPDB 199 2e-51 1CM7-A nrPDB 178 3e-45 1CNZ-A nrPDB 176 1e-44 Sequences not found previously or not previously below threshold: 5M2E-A nrPDB 240 1e-63 1AI3-A nrPDB 237 6e-63 3DMS-A nrPDB 230 1e-60 2IV0-A nrPDB 230 1e-60 2D4V-A nrPDB 226 2e-59 1HQS-A nrPDB 219 2e-57 1XGV-A nrPDB 211 4e-55 4IWH-A nrPDB 173 1e-43 4Y1P-A nrPDB 171 5e-43 1WPW-A nrPDB 169 2e-42 1VLC-A nrPDB 163 1e-40 3BLV-B nrPDB 163 1e-40 3VMK-A nrPDB 161 8e-40 3VML-A nrPDB 157 1e-38 3VMJ-A nrPDB 156 1e-38 5J32-A nrPDB 155 3e-38 3ASJ-A nrPDB 154 6e-38 3TY3-A nrPDB 148 5e-36 3BLX-A nrPDB 146 2e-35 5GRH-B nrPDB 143 1e-34 5HN5-A nrPDB 136 1e-32 1XAD-A nrPDB 134 9e-32 1IDM-A nrPDB 132 3e-31 3UDO-A nrPDB 130 1e-30 3FMX-X nrPDB 119 2e-27 2G4O-A nrPDB 118 5e-27 1J1W-A nrPDB 39 0.004 2B0T-A nrPDB 38 0.007 5Z16-A nrPDB 36 0.037 4ZDA-A nrPDB 35 0.052 6G3U-A nrPDB 33 0.30 1XDT-T nrPDB 32 0.61 5KVU-A nrPDB 32 0.62 4OM9-A nrPDB 32 0.67 5L2E-A nrPDB 29 3.1 5CC2-A nrPDB 29 3.1 >2QFY-A nrPDB Length = 427 Score = 599 bits (1545), Expect = e-172, Method: Composition-based stats. Identities = 413/414 (99%), Positives = 413/414 (99%) Query: 15 AAFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQ 74 AFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQ Sbjct: 14 HAFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQ 73 Query: 75 DAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIP 134 DAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIP Sbjct: 74 DAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIP 133 Query: 135 RLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSG 194 RLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSG Sbjct: 134 RLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSG 193 Query: 195 VAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKS 254 VAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKS Sbjct: 194 VAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKS 253 Query: 255 KFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVT 314 KFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVT Sbjct: 254 KFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVT 313 Query: 315 PDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFAN 374 PDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFAN Sbjct: 314 PDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFAN 373 Query: 375 ILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKSIE 428 ILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKSIE Sbjct: 374 ILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKSIE 427 >5I96-A nrPDB Length = 458 Score = 581 bits (1498), Expect = e-166, Method: Composition-based stats. Identities = 256/416 (61%), Positives = 314/416 (75%), Gaps = 7/416 (1%) Query: 13 RLAAFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKI 72 R A +IKV +PVVE+DGDEMTRIIW IK+KLILP++D+ LKY+DL + +RD T D++ Sbjct: 37 RHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQV 96 Query: 73 TQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPR 132 T D+A A +KY V +KCATITPDEARV+EF L KMWKSPNGTI+NILGGTVFREPI+ Sbjct: 97 TIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIQNILGGTVFREPIICKN 156 Query: 133 IPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKG 192 IPRLVP W KPI IGRHAHGDQYKATD + G+ ++V+ P D + + +VY++ Sbjct: 157 IPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVK--EWEVYNFPA 214 Query: 193 SGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQY 252 GV M MYNTDESI GFAHS F+ AI KK L++STKNTILK YDGRFKDIFQE+++ Y Sbjct: 215 GGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHY 274 Query: 253 KSKFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSIL 312 K+ F++ I YEHRLIDDMVAQ++KS GGF+ A KNYDGDVQSDI+AQGFGSLGLMTS+L Sbjct: 275 KTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVL 334 Query: 313 VTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKF 372 V PDGKT E+EAAHGTVTRHYR++QKG TSTN IASIFAW+RGL RG+LD L +F Sbjct: 335 VCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRF 394 Query: 373 ANILESATLNTVQQDGIMTKDLALACGNNERSA----YVTTEEFLDAVEKRLQKEI 424 A +LE + TV+ G MTKDLA ++ T +FLD ++ L + + Sbjct: 395 AQMLEKVCVETVES-GAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449 >3US8-A nrPDB Length = 427 Score = 565 bits (1456), Expect = e-161, Method: Composition-based stats. Identities = 259/410 (63%), Positives = 318/410 (77%), Gaps = 6/410 (1%) Query: 17 FSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDA 76 +KIKV PVVELDGDEMTRIIW IK KLI PYLD+DL+YYDL VE+RDAT D++T DA Sbjct: 24 MAKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLDLEYYDLGVENRDATDDQVTIDA 83 Query: 77 AEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRL 136 A AIKK+GVG+KCATITPDE RV+EF L KMWKSPNGTIRNILGG +FREPI+ +PRL Sbjct: 84 ANAIKKHGVGVKCATITPDEGRVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRL 143 Query: 137 VPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVA 196 VP W KPII+GRHA GDQY+ATD PG G L + + D T + VYD G+GVA Sbjct: 144 VPGWTKPIIVGRHAFGDQYRATDFKFPGKGKLSIKFVGEDGQTIEHD---VYDAPGAGVA 200 Query: 197 MAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKF 256 +AMYN DESI FA +SF + +K+ ++LSTKNTILK YDGRFKDIFQ+V++ ++ ++F Sbjct: 201 LAMYNLDESITEFARASFNYGLQRKVPVYLSTKNTILKAYDGRFKDIFQKVFDEEFAAQF 260 Query: 257 EQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPD 316 + + YEHRLIDDMVA +K GG++ A KNYDGDVQSDIVAQGFGSLGLMTS+L+TPD Sbjct: 261 KAEKLWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPD 320 Query: 317 GKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANIL 376 GKT E+EAAHGTVTRHYR++QKGEETSTNSIASIFAW+RGL R +LD L KF+ L Sbjct: 321 GKTVEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDGNAELAKFSETL 380 Query: 377 ESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKS 426 E ++TV+ G MTKDLAL G ++ +++T FLD +++ L+K + + Sbjct: 381 ERVCVDTVES-GFMTKDLALLIGPDQP--WLSTTGFLDKIDENLRKAMAA 427 >4HCX-A nrPDB Length = 409 Score = 560 bits (1443), Expect = e-160, Method: Composition-based stats. Identities = 253/408 (62%), Positives = 310/408 (75%), Gaps = 4/408 (0%) Query: 19 KIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAE 78 KIKV PVVELDGDEMTR+IW IK LILPYLD+ L YYDL +E RDAT D++T DAA Sbjct: 6 KIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDYYDLGIEHRDATDDQVTIDAAY 65 Query: 79 AIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVP 138 AIKK+GVG+KCATITPDEARV+EFNL KMW SPNGTIRNILGGT+FREPIVI +PRLVP Sbjct: 66 AIKKHGVGVKCATITPDEARVEEFNLKKMWLSPNGTIRNILGGTIFREPIVISNVPRLVP 125 Query: 139 RWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMA 198 W KPI+IGRHA GDQY+AT+ + PG++ L + P+D + + G GV + Sbjct: 126 GWTKPIVIGRHAFGDQYRATNFKVDQPGTVTLTFTPADGSAPIVHEMVSIPEDG-GVVLG 184 Query: 199 MYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQ 258 MYN ESI FA +SF ++ K ++LSTKNTILK YDG FKD F+ VYE ++K++FE Sbjct: 185 MYNFKESIRDFARASFSYGLNAKWPVYLSTKNTILKAYDGMFKDEFERVYEEEFKAQFEA 244 Query: 259 LGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGK 318 G+ YEHRLIDDMVA +K +GG++ A KNYDGDVQSD VAQG+GSLGLMTS+L+T DGK Sbjct: 245 AGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTADGK 304 Query: 319 TFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILES 378 T E+EAAHGTVTRHYR+YQ G+ TSTN IASIFAW+RGL RG+LD TP + FA+ LES Sbjct: 305 TVEAEAAHGTVTRHYRQYQAGKPTSTNPIASIFAWTRGLQHRGKLDGTPEVIDFAHKLES 364 Query: 379 ATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKS 426 + TV+ G MTKDLA+ G + ++ +EEFLDA+ L+KE+ + Sbjct: 365 VVIATVES-GKMTKDLAILIGPEQD--WLNSEEFLDAIADNLEKELAN 409 >6BL1-B nrPDB Length = 425 Score = 548 bits (1411), Expect = e-156, Method: Composition-based stats. Identities = 269/413 (65%), Positives = 325/413 (78%), Gaps = 7/413 (1%) Query: 17 FSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDA 76 SK VVE+ GDEMTRIIW+ IK+KLI PY+++DL YDL +E+RDAT+D++T+DA Sbjct: 1 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA 60 Query: 77 AEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRL 136 AEAIKK+ VG+KCATITPDE RV+EF L +MWKSPNGTIRNILGGTVFRE I+ IPRL Sbjct: 61 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL 120 Query: 137 VPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYK-GSGV 195 V W KPIIIGRHA+GDQY+ATD ++PGPG +E+ Y PSD T Q T V++++ G GV Sbjct: 121 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGT--QKVTYLVHNFEEGGGV 178 Query: 196 AMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSK 255 AM MYN D+SIE FAHSSF++A+ K L+LSTKNTILKKYDGRFKDIFQE+Y+ QYKS+ Sbjct: 179 AMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQ 238 Query: 256 FEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTP 315 FE I YEHRLIDDMVAQ +KS+GGFI A KNYDGDVQSD VAQG+GSLG+MTS+LV P Sbjct: 239 FEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCP 298 Query: 316 DGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANI 375 DGKT E+EAAHGTVTRHYR YQKG+ETSTN IASIFAW+RGL R +LDN L FAN Sbjct: 299 DGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANA 358 Query: 376 LESATLNTVQQDGIMTKDLA---LACGNNERSAYVTTEEFLDAVEKRLQKEIK 425 LE ++ T++ G MTKDLA N +RS Y+ T EF+D + + L+ ++ Sbjct: 359 LEEVSIETIEA-GFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLA 410 >4AOY-A nrPDB Length = 402 Score = 528 bits (1360), Expect = e-150, Method: Composition-based stats. Identities = 225/405 (55%), Positives = 292/405 (72%), Gaps = 6/405 (1%) Query: 17 FSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDA 76 SKIK+K P+VE+DGDEMTRIIW IK+ L+ PY++++ +YYDL +E+RD T D++T DA Sbjct: 1 MSKIKMKVPLVEMDGDEMTRIIWRLIKENLLEPYIELNTEYYDLGLENRDKTEDQVTIDA 60 Query: 77 AEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRL 136 A AI+KYGVG+KCATITP+ RV+E+NL KMWKSPNGTIR IL GTVFR PIV+ I Sbjct: 61 ARAIQKYGVGVKCATITPNAQRVEEYNLKKMWKSPNGTIRAILDGTVFRAPIVVNSIKPF 120 Query: 137 VPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVA 196 V W+KPI I RHA+GD YK + +P G ELV+ + ++ ++++ G GV Sbjct: 121 VKGWKKPISIARHAYGDVYKNVEYYVPSAGKAELVFTSENGEVSRQT---IHEFDGPGVI 177 Query: 197 MAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKF 256 M M+NTD+SI FA + F A+D +L+ STK+TI K YD RFKDIFQE+YE +YK KF Sbjct: 178 MGMHNTDKSIRSFARACFNYALDMNQDLWFSTKDTISKTYDHRFKDIFQEIYENEYKEKF 237 Query: 257 EQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPD 316 E + Y + LIDD VA++I+S+GG + A KNYDGDV SD+VA FGSL +MTS+LV+PD Sbjct: 238 EAKNLQYFYTLIDDAVARIIRSEGGMVWACKNYDGDVMSDMVASAFGSLAMMTSVLVSPD 297 Query: 317 GKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANIL 376 GK +E EAAHGTVTRHY K+ KGEETSTNS+A+IFAW+ L KRGELD L FA L Sbjct: 298 GK-YEFEAAHGTVTRHYYKHLKGEETSTNSMATIFAWTGALKKRGELDGIKELVDFATKL 356 Query: 377 ESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQ 421 E A++ T++ +G+MTKDLA E+ V TE+FL + K + Sbjct: 357 EQASVQTIE-NGVMTKDLASLSEVPEKKI-VNTEDFLKEIRKTFE 399 >1ZOR-A nrPDB Length = 399 Score = 517 bits (1331), Expect = e-147, Method: Composition-based stats. Identities = 223/408 (54%), Positives = 298/408 (73%), Gaps = 9/408 (2%) Query: 17 FSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDA 76 K+KVK P+VELDGDEM R++W IK+KLILPYLD+ L Y+DL ++ RD T D+IT +A Sbjct: 1 MEKVKVKNPIVELDGDEMARVMWKMIKEKLILPYLDIQLVYFDLGIKKRDETDDQITIEA 60 Query: 77 AEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRL 136 A+AIKKYGVG+KCATITPD RVKE+NL K WKSPN TIR L GTVFR+PI++ +P L Sbjct: 61 AKAIKKYGVGVKCATITPDAERVKEYNLKKAWKSPNATIRAYLDGTVFRKPIMVKNVPPL 120 Query: 137 VPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVA 196 V RW+KPIIIGRHA+GD Y A + + GP +ELV + + +TL V+ ++G+GV Sbjct: 121 VKRWKKPIIIGRHAYGDIYNAVEAKVEGPAEVELVVR-----NKENKTLLVHKFEGNGVV 175 Query: 197 MAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKF 256 MAM+N ++SI FA S AI +K++++ +TK+TI K Y FKDIFQE + + K + Sbjct: 176 MAMHNLEKSIRSFAQSCINYAISEKVDIWFATKDTISKVYHAYFKDIFQEEVDKR-KEEL 234 Query: 257 EQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPD 316 E+ G++Y + LIDD AQ+++S+GG + A NY+GD+ SD++A GFGSLGLMTS+LV+PD Sbjct: 235 EKAGVNYRYMLIDDAAAQILRSEGGMLWACMNYEGDIMSDMIASGFGSLGLMTSVLVSPD 294 Query: 317 GKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANIL 376 G +E EAAHGTV RHY +Y KGE+TSTN ASIFAW+ + KRGELD TP +C+FA+ L Sbjct: 295 G-VYEFEAAHGTVRRHYYRYLKGEKTSTNPTASIFAWTGAIRKRGELDGTPEVCEFADKL 353 Query: 377 ESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEI 424 E A +NT++ G++TKDL YVT EEF+D V+K L+K + Sbjct: 354 EKAVINTIES-GVITKDLQ-PFTEPPIDKYVTLEEFIDEVKKNLEKLL 399 >2UXQ-A nrPDB Length = 402 Score = 517 bits (1330), Expect = e-147, Method: Composition-based stats. Identities = 202/404 (50%), Positives = 282/404 (69%), Gaps = 6/404 (1%) Query: 19 KIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAE 78 KI++K P+VELDGDEMTR++W IK KL+LP++D+ +YYDL +E RD T+D+IT DAAE Sbjct: 2 KIQMKTPLVELDGDEMTRVLWPLIKDKLLLPFIDLQTEYYDLGIEERDRTNDQITIDAAE 61 Query: 79 AIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVP 138 AIKKYGVG+K ATITP++ RV+E+ L + WKSPN T+R +L GTVFR+PI++ I V Sbjct: 62 AIKKYGVGVKNATITPNQDRVEEYGLKEQWKSPNATVRAMLDGTVFRKPIMVKNIKPSVR 121 Query: 139 RWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMA 198 W+KPI++GRHA+GD YK + G LE+V + + ++V + + Sbjct: 122 SWQKPIVVGRHAYGDFYKNAEIFAEAGGKLEIVVTDKNGKETRQTIMEVDE---PAIVQG 178 Query: 199 MYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQ 258 ++NT SI FA + F+ ++D+K++ + +TK+TI K+YD RFK IF+E++ +YK KF Sbjct: 179 IHNTVASIGHFARACFEYSLDQKIDCWFATKDTISKQYDQRFKIIFEEIFAQEYKEKFAA 238 Query: 259 LGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGK 318 GI Y + LIDD+VA+M+K++GG + A KNYDGDV SD+VA FGSL +M+S+LV+P G Sbjct: 239 AGIEYFYTLIDDVVARMMKTEGGMLWACKNYDGDVMSDMVASAFGSLAMMSSVLVSPYG- 297 Query: 319 TFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILES 378 FE EAAHGTV RHY ++ KGE TSTN +A I+AW+ L KRGELD TP LC F + LE+ Sbjct: 298 YFEYEAAHGTVQRHYYQHLKGERTSTNPVALIYAWTGALRKRGELDGTPDLCAFCDSLEA 357 Query: 379 ATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQK 422 T+ ++ G MT DLA C + + EF+D + KRLQ+ Sbjct: 358 ITIECIES-GYMTGDLARIC-EPAAIKVLDSIEFIDELGKRLQQ 399 >6C0E-A nrPDB Length = 419 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 74/371 (19%), Positives = 142/371 (38%), Gaps = 50/371 (13%) Query: 67 ATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFRE 126 + ++ +A+KKY V IK TP ++ S N IR + V Sbjct: 82 GGDQWLPKETLDAMKKYVVSIKGPLTTPVGGGIR---------SLNVAIRQDMDLYVCLR 132 Query: 127 PI-VIPRIPRLVPR-WEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQT 184 PI +P V W+ ++I R D Y + P + +++ + + Sbjct: 133 PIRYFNGVPSPVREPWKTDMVIFRENSEDIYAGIEWQADTPEAKKVIQFLTKEMGVK--K 190 Query: 185 LKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDK-KLNLFLSTKNTILKKYDGRFKDI 243 ++ ++ G GV + E ++ + AID + + L K I+K +G FKD Sbjct: 191 IRFPEHCGIGVKPV---SREGTTRLVKAAIQYAIDNDRSTVTLVHKGNIMKFTEGAFKDW 247 Query: 244 FQEVYEAQYKSKFEQLGIHYEHR--------LIDDMVAQ------MIKSKGGFIMALKNY 289 +V + +K Q G E + +I+D++A +++ + ++A N Sbjct: 248 GYQVARDSFGAKEYQGGPWMEFKNPKTGKQIIINDVIADAFLQQILLRPEDYSVIATLNL 307 Query: 290 DGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIAS 349 +GD SD +A G +G+ ++ F EA HGT ++ + N + Sbjct: 308 NGDYISDALAAQVGGIGIAPGANISDQMAVF--EATHGTAPKYAGQ------NKVNPGSI 359 Query: 350 IFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTT 409 I + L G + A+++ + + +T D + V++ Sbjct: 360 ILSAEMMLRHMG-------WYEAADLIIRG-MEGAIEAKTVTYDFERGMQG---ATLVSS 408 Query: 410 EEFLDAVEKRL 420 F DA+ K + Sbjct: 409 SGFADAMIKHM 419 >2E5M-A nrPDB Length = 409 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 87/375 (23%), Positives = 154/375 (41%), Gaps = 56/375 (14%) Query: 61 SVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILG 120 ++ +D+ ++ E + KY V +K TP + K WKS N IR +L Sbjct: 69 GEKAEKLVNDRFPKETQEMLLKYRVVLKGPLETP---------IGKGWKSVNVAIRLMLD 119 Query: 121 GTVFREPI-VIPRIPRLVPRWEK-PIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPT 178 P+ I + + EK +II R D Y+ + P + E K D Sbjct: 120 LYANIRPVKYIEGLESPLKHPEKVDMIIFRENTDDLYRGIEY----PFNSEEAKKIRDFL 175 Query: 179 TAQPQTLKVYDYKGSGV-AMAMYNTDESIEGFAHSSFKLAIDK-KLNLFLSTKNTILKKY 236 + + +++ D G G+ M+ Y T + + AI+ + + + K ++K Sbjct: 176 RKELK-VEIEDDTGIGIKVMSKYKTQ----RITRLAIQYAIEHKRKKVTIMHKGNVMKYT 230 Query: 237 DGRFKDIFQEVYEAQYKS-----------KFEQLGIHYEHRLIDDMVAQMIKSKGGF-IM 284 +G F++ EV +Y+ K +Q I R+ D+M Q+I + I+ Sbjct: 231 EGAFREWAYEVALKEYRDFIVTEEEINQGKPDQGKIILNDRIADNMFQQIIIRPEEYDII 290 Query: 285 ALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETST 344 N +GD SD G++G++ + +G F EA HGT ++ K Sbjct: 291 LAPNVNGDYISDAAGALIGNIGMLGGANIGDEGGMF--EAIHGTAPKYAGK------NVA 342 Query: 345 NSIASIFAWSRGLLKRGELD-NTPALCKFANILESATLNTVQQDGIMTKDLALACGNNER 403 N G++K GEL + A+++E A +N +D +T+D+A G Sbjct: 343 NPT--------GIIKAGELMLRWMGWNEAADLIEKA-INMAIRDKKVTQDIARFMGV--- 390 Query: 404 SAYVTTEEFLDAVEK 418 + T+E+ D + K Sbjct: 391 -KALGTKEYADELIK 404 >2D1C-A nrPDB Length = 496 Score = 264 bits (675), Expect = 4e-71, Method: Composition-based stats. Identities = 81/361 (22%), Positives = 145/361 (40%), Gaps = 68/361 (18%) Query: 65 RDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVF 124 R + + Q+ E+I+K V +K TP + KS N T+R + Sbjct: 62 RRGIASGVPQETIESIRKTRVVLKGPLETP---------VGYGEKSANVTLRKLFETYAN 112 Query: 125 REPIV-IPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQ 183 P+ P +P +++ R D Y + + P+ AQ Sbjct: 113 VRPVREFPNVPTPYAGRGIDLVVVRENVEDLYAGIEHM-------------QTPSVAQ-- 157 Query: 184 TLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLA-IDKKLNLFLSTKNTILKKYDGRFKD 242 TLK+ +KGS E +F+LA + + + +TK+ I+K +G K Sbjct: 158 TLKLISWKGS-------------EKIVRFAFELARAEGRKKVHCATKSNIMKLAEGTLKR 204 Query: 243 IFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQG 301 F++V + E I H ++D+ Q++K F ++ N +GD+ SD+ + Sbjct: 205 AFEQVAQ-------EYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDILSDLTSGL 257 Query: 302 FGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRG 361 G LG S + + F EA HG+ ++ K N A + + L Sbjct: 258 IGGLGFAPSANIGNEVAIF--EAVHGSAPKYAGK------NVINPTAVLLSAVMMLRYLE 309 Query: 362 ELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQ 421 E A+++E+A L T+++ ++T D+ +R A T E+ +A+ + L Sbjct: 310 EFAT-------ADLIENALLYTLEEGRVLTGDVV----GYDRGAK--TTEYTEAIIQNLG 356 Query: 422 K 422 K Sbjct: 357 K 357 >5M2E-A nrPDB Length = 418 Score = 240 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 68/369 (18%), Positives = 139/369 (37%), Gaps = 50/369 (13%) Query: 69 SDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPI 128 + Q+ +A++ Y V IK TP ++ S N +R L V + P+ Sbjct: 83 DTWLPQETLDAVRDYVVSIKGPLTTPVGGGIR---------SLNVALRQQLDLYVCQRPV 133 Query: 129 V-IPRIPRLVPRWE-KPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLK 186 +P V + ++I R D Y + P + +++ ++ + ++ Sbjct: 134 RWFEGVPSPVKKPGDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLTEEMGVK--KIR 191 Query: 187 VYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDK-KLNLFLSTKNTILKKYDGRFKDIFQ 245 + G G+ + E + + + A+D + ++ L K I+K +G FKD Sbjct: 192 FTENCGIGIKPV---SQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGAFKDWGY 248 Query: 246 EVYEAQYKSKFEQLGIHYEHR-------------LIDDMVAQMIKSKGGF-IMALKNYDG 291 EV ++ ++ G + + + D M+ Q++ + ++A N +G Sbjct: 249 EVARDEFGAELLDGGPWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIATLNLNG 308 Query: 292 DVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIF 351 D SD +A G +G+ ++ F EA HGT ++ + N + I Sbjct: 309 DYLSDALAAEVGGIGIAPGANLSDSVAMF--EATHGTAPKYAGQ------DKVNPGSLIL 360 Query: 352 AWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEE 411 + L G + A+++ T N +T D + ++ E Sbjct: 361 SAEMMLRHMG-------WTEAADLIIKGT-NGAIAAKTVTYDFERLMDG---ATLLSCSE 409 Query: 412 FLDAVEKRL 420 F DA+ ++ Sbjct: 410 FGDAMIAKM 418 >1AI3-A nrPDB Length = 416 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 61/366 (16%), Positives = 132/366 (36%), Gaps = 50/366 (13%) Query: 72 ITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPI-VI 130 + + + I++Y V IK TP ++ S N +R L + P+ Sbjct: 84 LPAETLDLIREYRVAIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYY 134 Query: 131 PRIPRLVPRWE-KPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYD 189 P V E ++I R D Y + + +++ + + ++ + Sbjct: 135 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVK--KIRFPE 192 Query: 190 YKGSGVAMAMYNTDESIEGFAHSSFKLAI-DKKLNLFLSTKNTILKKYDGRFKDIFQEVY 248 + G G+ ++E + ++ + AI + + ++ L K I+K +G FKD ++ Sbjct: 193 HCGIGIKPC---SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 249 Query: 249 EAQYKSKFEQLGIHYE-------------HRLIDDMVAQMIKSKGGF-IMALKNYDGDVQ 294 ++ + G + + D + Q++ + ++A N +GD Sbjct: 250 REEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYI 309 Query: 295 SDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWS 354 SD +A G +G+ + + F EA HGT ++ + N + I + Sbjct: 310 SDALAAQVGGIGIAPGANIGDECALF--EATHGTAPKYAGQ------DKVNPGSIILSAE 361 Query: 355 RGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLD 414 L G + A+++ + +T D + + EF D Sbjct: 362 MMLRHMG-------WTEAADLIVKG-MEGAINAKTVTYDFERLMDG---AKLLKCSEFGD 410 Query: 415 AVEKRL 420 A+ + + Sbjct: 411 AIIENM 416 >3DMS-A nrPDB Length = 427 Score = 230 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 68/367 (18%), Positives = 138/367 (37%), Gaps = 50/367 (13%) Query: 72 ITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPI-VI 130 + ++ + +K+Y V IK TP ++ S N +R L V PI Sbjct: 94 LPEETLQVLKEYVVSIKGPLTTPVGGGIR---------SLNVALRQELDLYVCLRPIQYF 144 Query: 131 PRIPRLVPRWEK-PIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYD 189 +P V EK ++I R D Y + + +++ + + ++ Sbjct: 145 KGVPSPVREPEKTNMVIFRENSEDIYAGIEWAAESEQAKKVIKFLQEEMGVK--KIRFPQ 202 Query: 190 YKGSGVAMAMYNTDESIEGFAHSSFKLAIDK-KLNLFLSTKNTILKKYDGRFKDIFQEVY 248 G G+ + E E + + AID + ++ L K I+K +G F+D + Sbjct: 203 TSGIGIKPV---SKEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTEGAFRDAGYALA 259 Query: 249 EAQYKSKFEQLGIHYEHR-------------LIDDMVAQMIKSKGGF-IMALKNYDGDVQ 294 + ++ ++ G + + + D + Q++ + ++A N +GD Sbjct: 260 QKEFGAELIDGGPWMKFKNPKTGNEIVVKDSIADAFLQQILLRPAEYDVIATLNLNGDYI 319 Query: 295 SDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWS 354 SD +A G +G+ ++ F EA HGT ++ K N + I + Sbjct: 320 SDALAAQVGGIGIAPGANLSDSVAMF--EATHGTAPKYAGK------DYVNPGSEILSAE 371 Query: 355 RGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLD 414 L G + A+++ SA +++Q + T D A + V+ F Sbjct: 372 MMLRHLG-------WTEAADVIISAMEKSIKQKRV-TYDFARLMEG---ATQVSCSGFGQ 420 Query: 415 AVEKRLQ 421 + + ++ Sbjct: 421 VLIENME 427 >2IV0-A nrPDB Length = 412 Score = 230 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 76/368 (20%), Positives = 136/368 (36%), Gaps = 55/368 (14%) Query: 72 ITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVI- 130 + D AIK++ V +K TP ++S N TIR +L P+ Sbjct: 80 LPDDTLNAIKEFRVALKGPLTTPVGG---------GYRSLNVTIRQVLDLYANVRPVYYL 130 Query: 131 PRIPRLVPRWEK-PIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYD 189 +P + EK +I R D Y + +L+L+ + + + Sbjct: 131 KGVPSPIKHPEKVNFVIFRENTEDVYAGIEWPRGSEEALKLIRFLKNEFGVTIR-----E 185 Query: 190 YKGSGVAMAMYNTDESIEGFAHSSFKLAI-DKKLNLFLSTKNTILKKYDGRFKDIFQEVY 248 G G+ ++ + + + + AI + + ++ L K I+K +G F+D EV Sbjct: 186 DSGIGIKPI---SEFATKRLVRMAIRYAIENNRKSVTLVHKGNIMKYTEGAFRDWGYEVA 242 Query: 249 EAQ--------------YKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDV 293 + + Y K + I + R+ D+M Q++ + ++AL N +GD Sbjct: 243 KQEFGEYCITEDELWDKYGGKQPEGKIVVKDRIADNMFQQILTRTDEYDVIALPNLNGDY 302 Query: 294 QSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAW 353 SD A G LG+ + E HG+ ++ + N A I Sbjct: 303 LSDAAAALIGGLGIAPGSNIGD--GIGVFEPVHGSAPKYAGQ------NKVNPTAEILTG 354 Query: 354 SRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFL 413 + G + +++ A + GI+T D+ G V T EF Sbjct: 355 ALMFEYIG-------WKDASEMIKKA-VEMTISSGIVTYDIHRHMGG----TKVGTREFA 402 Query: 414 DAVEKRLQ 421 +AV + LQ Sbjct: 403 EAVVENLQ 410 >2D4V-A nrPDB Length = 429 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 70/379 (18%), Positives = 133/379 (35%), Gaps = 63/379 (16%) Query: 72 ITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPI-VI 130 + + AI++Y V IK TP ++ S N +R L V P+ Sbjct: 84 LPDETMAAIREYKVAIKGPLETPVGGGIR---------SLNVAMRQDLDLYVCLRPVRYF 134 Query: 131 PRIPRLVPRWEK-PIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYD 189 P + EK ++I R D Y + P + +++ + ++ D Sbjct: 135 EGTPSPMRHPEKVDMVIFRENSEDIYAGIEWPAGSPEAEKIIRFLREEMGV--TKIRFPD 192 Query: 190 YKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLN-LFLSTKNTILKKYDGRFKDIFQEVY 248 G+ + E E + + A++ + L K I+K +G F+D + Sbjct: 193 SSAIGIKPV---STEGSERLIRRTIQYALEHGKPSVSLVHKGNIMKFTEGGFRDWGYALA 249 Query: 249 EAQYKSK--------------------------FEQLGIHYEHRLIDDMVAQ-MIKSKGG 281 E ++ + + + + D+ + Q +++ + Sbjct: 250 EREFAGRVFTWRQKAAISKAEGKAAGQKAEQQAIADGKLIIKDVIADNFLQQILLRPEDY 309 Query: 282 FIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEE 341 ++A N +GD SD +A G +G+ ++ F EA HGT + + Sbjct: 310 SVVATLNLNGDYVSDALAAEVGGIGMAPGANLSDTHAIF--EATHGTAPDIAGQGK---- 363 Query: 342 TSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNN 401 N + I + L G + A + +A T+ G +T DLA G Sbjct: 364 --ANPSSLILSAVMMLEHLG-------WGEAAQAIVAAMNATI-AAGEVTGDLAALRG-- 411 Query: 402 ERSAYVTTEEFLDAVEKRL 420 ++T EF A+ +R Sbjct: 412 -DVPALSTTEFTAALIRRF 429 >1HQS-A nrPDB Length = 423 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 69/391 (17%), Positives = 136/391 (34%), Gaps = 61/391 (15%) Query: 61 SVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILG 120 ++ + T + + + + I++Y + IK TP ++ S N +R L Sbjct: 64 GEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGIR---------SLNVALRQELD 114 Query: 121 GTVFREPI-VIPRIPRLVPRWE-KPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPT 178 V P+ +P V R E ++I R D Y + +L+ + Sbjct: 115 LFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGSEEVQKLISFLQNEL 174 Query: 179 TAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDK-KLNLFLSTKNTILKKYD 237 ++ + G G+ ++E ++ AI+ + ++ L K I+K + Sbjct: 175 NV--NKIRFPETSGIGIKPV---SEEGTSRLVRAAIDYAIEHGRKSVTLVHKGNIMKFTE 229 Query: 238 GRFKDIFQEVYEAQYKSK--------------------------FEQLGIHYEHRLIDDM 271 G FK+ E+ E +Y K I + + D Sbjct: 230 GAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAAGKIIIKDSIADIF 289 Query: 272 VAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVT 330 + Q++ F ++A N +GD SD +A G +G+ + + EA HGT Sbjct: 290 LQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAP 349 Query: 331 RHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIM 390 ++ N + I + L G + A+++ + T+ ++ Sbjct: 350 KYAG------LDKVNPSSVILSGVLLLEHLG-------WNEAADLVIKSMEKTI-ASKVV 395 Query: 391 TKDLALACGNNERSAYVTTEEFLDAVEKRLQ 421 T D A + V EF + + K + Sbjct: 396 TYDFARLMDG---ATEVKCSEFGEELIKNMD 423 >5YVT-A nrPDB Length = 339 Score = 213 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 73/374 (19%), Positives = 134/374 (35%), Gaps = 87/374 (23%) Query: 63 ESRDATSDK-------ITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTI 115 E R+ T+ + I +A E++ K +G+K TP A S N + Sbjct: 37 EERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAA---------GHPSMNLLL 87 Query: 116 RNILGGTVFREPIVIPRIPRLVPRWEKP-----IIIGRHAHGDQYKATDTLIPGPGSLEL 170 R P V + ++ P I+ R +Y + +I G ++ Sbjct: 88 RKTFDLYANVRPCV------SIEGYKTPYTDVNIVTIRENTEGEYSGIEHVI-VDGVVQS 140 Query: 171 VYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAI-DKKLNLFLSTK 229 + ++ + A +F+ A + + N+ K Sbjct: 141 IKLITEGASK---------------------------RIAEFAFEYARNNHRSNVTAVHK 173 Query: 230 NTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMALKN 288 I++ DG F +EV E+ KF + +D + M++ F ++ + N Sbjct: 174 ANIMRMSDGLFLQKCREVAESCKDIKFNE-------MYLDTVCLNMVQDPSQFDVLVMPN 226 Query: 289 YDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIA 348 GD+ SD+ A G LG+ S + +G E+ HGT K N A Sbjct: 227 LYGDILSDLCAGLIGGLGVTPSGNIGANGVAI-FESVHGTAPDIAGK------DMANPTA 279 Query: 349 SIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVT 408 + + L G D+ A +E+A T++ +TKDL G N + + Sbjct: 280 LLLSAVMMLRHMGLFDH-------AARIEAACFATIKDGKSLTKDL----GGNAKCS--- 325 Query: 409 TEEFLDAVEKRLQK 422 +F + + +R++ Sbjct: 326 --DFTEEICRRVKD 337 >1XGV-A nrPDB Length = 435 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 62/376 (16%), Positives = 124/376 (32%), Gaps = 52/376 (13%) Query: 65 RDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVF 124 R+ + + + E I+ V +K TP + ++S N IR L Sbjct: 84 REKCGELLPKATLEGIRLARVALKGPLETP---------VGTGYRSLNVAIRQALDLYAN 134 Query: 125 REPIVIPRIPRLVP-RWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQ 183 P+ P ++I R D Y + P + + A+ Sbjct: 135 IRPVRYYGQPAPHKYADRVDMVIFRENTEDVYAGIEWPHDSPEAARIRRFL-----AEEF 189 Query: 184 TLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAI-DKKLNLFLSTKNTILKKYDGRFKD 242 + + + G GV + + + + A+ + + + K I+K +G F Sbjct: 190 GISIREDAGIGVKPI---SRFATRRLMERALEWALRNGNTVVTIMHKGNIMKYTEGAFMR 246 Query: 243 IFQEVYEAQYKSKF--------------EQLGIHYEHRLIDDMVAQMIKSK-GGFIMALK 287 EV +++ + I R+ D+M+ Q+I ++ Sbjct: 247 WAYEVALEKFREHVVTEQEVQEKYGGVRPEGKILVNDRIADNMLQQIITRPWDYQVIVAP 306 Query: 288 NYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSI 347 N +GD SD + G +G+ + + +E HGT ++ K N Sbjct: 307 NLNGDYISDAASALVGGIGMAAGMNMGDGIAV--AEPVHGTAPKYAGK------DLINPS 358 Query: 348 ASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYV 407 A I + S + GE + + + Q +T+DLA + + Sbjct: 359 AEILSASLLI---GEFMGWREV----KSIVEYAIRKAVQSKKVTQDLARHMPGVQP---L 408 Query: 408 TTEEFLDAVEKRLQKE 423 T E+ + + + + Sbjct: 409 RTSEYTETLIAYIDEA 424 >1A05-A nrPDB Length = 358 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 74/344 (21%), Positives = 126/344 (36%), Gaps = 61/344 (17%) Query: 66 DATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFR 125 DA+ D + + + I A P R + K + +R L Sbjct: 48 DASDDPLPAASLQLAMAADAVILGAVGGP---RWDAYPPAKRPEQGLLRLRKGLDLYANL 104 Query: 126 EPIVI--------PRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDP 177 P I P P LV + I++ R GD Y Sbjct: 105 RPAQIFPQLLDASPLRPELVR--DVDILVVRELTGDIYFG-------------------- 142 Query: 178 TTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYD 237 QP+ L+V D K G +Y+ DE I AH +F+ A ++ L K +L+ Sbjct: 143 ---QPRGLEVIDGKRRGFNTMVYDEDE-IRRIAHVAFRAAQGRRKQLCSVDKANVLETTR 198 Query: 238 GRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSD 296 ++++ EV + + H +D+ Q+I++ F ++ N GD+ SD Sbjct: 199 -LWREVVTEVAR-------DYPDVRLSHMYVDNAAMQLIRAPAQFDVLLTGNMFGDILSD 250 Query: 297 IVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRG 356 +Q GS+G++ S + E HG+ + N +A+I S Sbjct: 251 EASQLTGSIGMLPSASLGEGRAM--YEPIHGSAPDIAGQ------DKANPLATIL--SVA 300 Query: 357 LLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGN 400 ++ R L+ P +A +E+A + Q G+ T D+A Sbjct: 301 MMLRHSLNAEP----WAQRVEAAVQRVLDQ-GLRTADIAAPGTP 339 >3U1H-A nrPDB Length = 390 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 77/388 (19%), Positives = 140/388 (36%), Gaps = 74/388 (19%) Query: 52 DVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCAT------ITPDEARVKEFNLH 105 + + +Y + + D + ++ + + + A P E R ++ L Sbjct: 56 EFEFEYGLIGGAAIDEAGTPLPEETLDVCRGSDAILLGAVGGPKWDQNPSELRPEKGLLG 115 Query: 106 KMWKSPNGTIRNILGGTVFREPIVIPRIPRLVPRWEK------PIIIGRHAHGDQYKATD 159 IR L P+ + +K ++I R G Y Sbjct: 116 ---------IRKGLDLFANLRPVKVYDSLADASPLKKEVIEGVDLVIVRELTGGLYFG-- 164 Query: 160 TLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAID 219 + + + + + V +Y T E IE +F+LA+ Sbjct: 165 ----------------------EPSERYEEGEEAAVDTLLY-TREEIERIIRKAFELALT 201 Query: 220 KKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSK 279 +K + K +L+ +++EV E K E + EH L+D+ Q+I++ Sbjct: 202 RKKKVTSVDKANVLESS-----RLWREVAEEVAK---EYPDVELEHMLVDNAAMQLIRNP 253 Query: 280 GGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQK 338 F ++ +N GD+ SD + GSLG++ S ++ DG E HG+ K Sbjct: 254 RQFDVIVTENMFGDILSDEASMITGSLGMLPSASLSTDG-LGLYEPVHGSAPDIAGKGIA 312 Query: 339 GEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALAC 398 + S A + +S GL + A +E A + V +G T D+A Sbjct: 313 NPLATILSAAMMLRYSFGLEEE------------AKAIEKA-VEKVLAEGYRTADIAKPG 359 Query: 399 GNNERSAYVTTEEFLDAVEKRLQKEIKS 426 G YV+T E D V+ + E+ + Sbjct: 360 GK-----YVSTTEMTDEVKAAVVDELAT 382 >1V5B-A nrPDB Length = 366 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 75/373 (20%), Positives = 133/373 (35%), Gaps = 74/373 (19%) Query: 66 DATSDKITQDAAEAIKKYGVGIKCAT------ITPDEARVKEFNLHKMWKSPNGTIRNIL 119 D + ++ + ++ + A P R ++ L +R + Sbjct: 49 DEAGTPLPEETLDICRRSDAILLGAVGGPKWDHNPASLRPEKGLLG---------LRKEM 99 Query: 120 GGTVFREPI----VIPRIPRLVPRWEK--PIIIGRHAHGDQYKATDTLIPGPGSLELVYK 173 G P+ + L + ++I R G Y + GPG E+V Sbjct: 100 GLFANLRPVKAYATLLNASPLKRERVENVDLVIVRELTGGLYFGRPSERRGPGENEVVDT 159 Query: 174 PSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTIL 233 + T E IE +F+LA ++ L K +L Sbjct: 160 LA-------------------------YTREEIERIIEKAFQLAQIRRKKLASVDKANVL 194 Query: 234 KKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGD 292 + +++E+ E K + + H L+D Q+I + G F ++ +N GD Sbjct: 195 ESS-----RMWREIAEETAK---KYPDVELSHMLVDSTAMQLIANPGQFDVIVTENMFGD 246 Query: 293 VQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFA 352 + SD+ + GSLG++ S + D + E HG+ + + + S A + Sbjct: 247 ILSDLASVITGSLGMLPSASLRSD-RFGMYEPVHGSAPDIAGQGKANPLGTVLSAALMLR 305 Query: 353 WSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEF 412 +S GL K A +E A ++ V QDG T DL +A G V+T E Sbjct: 306 YSFGLEKE------------AAAIEKA-VDDVLQDGYCTGDLQVANGK-----VVSTIEL 347 Query: 413 LDAVEKRLQKEIK 425 D + ++L Sbjct: 348 TDRLIEKLNNSAA 360 >1CM7-A nrPDB Length = 363 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 73/382 (19%), Positives = 127/382 (33%), Gaps = 62/382 (16%) Query: 51 LDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKS 110 + + +YD+ + D + E ++ + + P + + + Sbjct: 36 MRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLPPD--QQPERG 93 Query: 111 PNGTIRNILGGTVFREPIV-------IPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIP 163 +R P + + I+ R G Y Sbjct: 94 ALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGRE 153 Query: 164 GPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLN 223 G G E + +Y+ IE A +F+ A ++ Sbjct: 154 GSGQYEKAFDTE-----------------------VYH-RFEIERIARIAFESARKRRHK 189 Query: 224 LFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF- 282 + K +L+ +++I E+ E + H ID+ Q+IK F Sbjct: 190 VTSIDKANVLQSS-ILWREIVNEIAT-------EYPDVELAHMYIDNATMQLIKDPSQFD 241 Query: 283 IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEET 342 ++ N GD+ SD A GS+G++ S + G E A G+ K Sbjct: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGL-YEPAGGSAPDIAGK------N 294 Query: 343 STNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNE 402 N IA I S LL R LD A C +E A +N ++GI T DLA Sbjct: 295 IANPIAQIL--SLALLLRYSLDADDAAC----AIERA-INRALEEGIRTGDLARG----- 342 Query: 403 RSAYVTTEEFLDAVEKRLQKEI 424 +A V+T+E D + + + + + Sbjct: 343 -AAAVSTDEMGDIIARYVAEGV 363 >1CNZ-A nrPDB Length = 363 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 70/382 (18%), Positives = 128/382 (33%), Gaps = 62/382 (16%) Query: 51 LDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKS 110 + + +YD+ + D + + E ++ + + P + + + + Sbjct: 36 MRITTSHYDVGGIAIDNHGHPLPKATVEGCEQADAILFGSVGGPKWENLPPES--QPERG 93 Query: 111 PNGTIRNILGGTVFREPIV-------IPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIP 163 +R P + + I+ R G Y Sbjct: 94 ALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGRE 153 Query: 164 GPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLN 223 G G E + +Y+ IE A +F+ A ++ Sbjct: 154 GSGQYEKAFDTE-----------------------VYH-RFEIERIARIAFESARKRRRK 189 Query: 224 LFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF- 282 + K +L+ +++E+ K+ + H ID+ Q+IK F Sbjct: 190 VTSIDKANVLQSS-----ILWREIVNDVAKT---YPDVELAHMYIDNATMQLIKDPSQFD 241 Query: 283 IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEET 342 ++ N GD+ SD A GS+G++ S + G E A G+ K Sbjct: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGL-YEPAGGSAPDIAGK------N 294 Query: 343 STNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNE 402 N IA I S LL R LD A +E A +N ++G+ T DLA Sbjct: 295 IANPIAQIL--SLALLLRYSLDAN----DAATAIEQA-INRALEEGVRTGDLARG----- 342 Query: 403 RSAYVTTEEFLDAVEKRLQKEI 424 +A V+T+E D + + + + + Sbjct: 343 -AAAVSTDEMGDIIARYVAEGV 363 >4IWH-A nrPDB Length = 363 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 68/319 (21%), Positives = 115/319 (36%), Gaps = 65/319 (20%) Query: 115 IRNILGGTVFREPIVI--------PRIPRLVPRWEKPIIIGRHAHGDQY----KATDTLI 162 +R L P + P P LV I+I R +GD Y + Sbjct: 97 LRKHLELFANFRPAICYPQLVDASPLKPELVAGL--DILIVRELNGDIYFGQPRGVRAAP 154 Query: 163 PGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKL 222 GP + + G Y+ E + AH +F+ A + Sbjct: 155 DGPFA----------------------GEREGFDTMRYSEPE-VRRIAHVAFQAAQKRAK 191 Query: 223 NLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF 282 L K+ +L+ ++D+ +V + E + H +D+ Q+ K+ F Sbjct: 192 KLLSVDKSNVLETSQ-FWRDVMIDVSK-------EYADVELSHMYVDNAAMQLAKAPKQF 243 Query: 283 -IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEE 341 ++ N GD+ SD + GS+G++ S + + K E +HG+ K Sbjct: 244 DVIVTGNMFGDILSDEASMLTGSIGMLPSASLDKNNKGL-YEPSHGSAPDIAGKG----- 297 Query: 342 TSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNN 401 N +A+I + +L R L+ + A+ +E A + TV + G T D+A Sbjct: 298 -IANPLATILSA--AMLLRYSLNR----AEQADRIERA-VKTVLEQGYRTGDIATPG--- 346 Query: 402 ERSAYVTTEEFLDAVEKRL 420 V T DAV L Sbjct: 347 --CRQVGTAAMGDAVVAAL 363 >4Y1P-A nrPDB Length = 337 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 67/391 (17%), Positives = 133/391 (34%), Gaps = 78/391 (19%) Query: 35 TRIIWDKIKKKLILP--YLDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATI 92 ++ I ++ +K LP Y++V+ +++ D + +D+ I+K + +K Sbjct: 21 SKTILARLNEKFSLPIEYIEVEA-----GDTTKNKFGDALPKDSLRVIEKADMILKGP-- 73 Query: 93 TPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVPRWE-KPIIIGRHAH 151 + + +R + P +P L ++ I++ R Sbjct: 74 -----------VGETAADVVVKLRLMYDLYANLRP--AKSLPGLENKFGDVDILVVRENT 120 Query: 152 GDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAH 211 D YK + +I SD T + + T + A Sbjct: 121 EDLYKGLEHVI------------SDGVTVGIKVI----------------TRAASTRIAQ 152 Query: 212 SSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDM 271 + A+ +K + K+ +++ DG F + + V + + Y +D Sbjct: 153 VALNQALRRKKKVVCVHKSNVMRITDGLFAESCRNVL---------KGKVEYSEMYVDAA 203 Query: 272 VAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVT 330 A ++++ F ++ +N GD+ SD Q GSLG+ S + F E HG Sbjct: 204 AANLVRNPQAFDVIVTENTYGDILSDEAGQIAGSLGISPSANIGDRKSLF--EPVHGAAF 261 Query: 331 RHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIM 390 K N A + + L + EL A L A + + + Sbjct: 262 DIAGK------NIANPTAFLLSVGMMLDRMQELSGDIRYNNAAKSLRDAIYSVYSEGKYL 315 Query: 391 TKDLALACGNNERSAYVTTEEFLDAVEKRLQ 421 T D+ TT+E + A+ ++ Sbjct: 316 TPDV---------GGSSTTDEMISAIRSKIG 337 >1WPW-A nrPDB Length = 336 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 70/389 (17%), Positives = 136/389 (34%), Gaps = 74/389 (19%) Query: 35 TRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITP 94 ++ I KI + LP ++++ D ++ + + +D+ + I K + +K Sbjct: 20 SKRILAKINELYSLPIEYIEVEAGDRALA---RYGEALPKDSLKIIDKADIILKGP---- 72 Query: 95 DEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVPRWEK-PIIIGRHAHGD 153 + + +R I P IP + ++ I+I R D Sbjct: 73 ---------VGESAADVVVKLRQIYDMYANIRP--AKSIPGIDTKYGNVDILIVRENTED 121 Query: 154 QYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSS 213 YK + ++ G V M + T + E A Sbjct: 122 LYKGFEHIVS---------------------------DGVAVGMKII-TRFASERIAKVG 153 Query: 214 FKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVA 273 A+ ++ + K +++ DG F + + V + + Y +D A Sbjct: 154 LNFALRRRKKVTCVHKANVMRITDGLFAEACRSVL---------KGKVEYSEMYVDAAAA 204 Query: 274 QMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRH 332 ++++ F ++ +N GD+ SD +Q GSLG+ S + F E HG Sbjct: 205 NLVRNPQMFDVIVTENVYGDILSDEASQIAGSLGIAPSANIGDKKALF--EPVHGAAFDI 262 Query: 333 YRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTK 392 K N A + + S + EL N K + LE+A ++ +T Sbjct: 263 AGK------NIGNPTAFLLSVSMMYERMYELSNDDRYIKASRALENAIYLVYKERKALTP 316 Query: 393 DLALACGNNERSAYVTTEEFLDAVEKRLQ 421 D+ G N TT++ ++ + +L Sbjct: 317 DV----GGNA-----TTDDLINEIYNKLG 336 >1VLC-A nrPDB Length = 366 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 60/317 (18%), Positives = 112/317 (35%), Gaps = 65/317 (20%) Query: 114 TIRNILGGTVFREPIVI-------PRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPG 166 +R +L PI + + V ++ R Y Sbjct: 105 ALRKMLNLYANIRPIKVYRSLVHVSPLKEKVIGSGVDLVTVRELSYGVYYG--------- 155 Query: 167 SLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFL 226 QP+ L + G +Y+ +++E A ++F++A +++ + Sbjct: 156 --------------QPRGL----DEEKGFDTMIYD-RKTVERIARTAFEIAKNRRKKVTS 196 Query: 227 STKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMA 285 K +L ++ + EV E + H +D+ Q+I F ++ Sbjct: 197 VDKANVL-YSSMLWRKVVNEVAR-------EYPDVELTHIYVDNAAMQLILKPSQFDVIL 248 Query: 286 LKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTN 345 N GD+ SD A GSLGL+ S E A G+ K N Sbjct: 249 TTNMFGDILSDESAALPGSLGLLPSASFGDKNL---YEPAGGSAPDIAGK------NIAN 299 Query: 346 SIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSA 405 IA I + + L + + + A +E A + V ++G T+D+A + Sbjct: 300 PIAQILSLAMMLEH------SFGMVEEARKIERA-VELVIEEGYRTRDIA-----EDPEK 347 Query: 406 YVTTEEFLDAVEKRLQK 422 V+T + D + K+L++ Sbjct: 348 AVSTSQMGDLICKKLEE 364 >3BLV-B nrPDB Length = 354 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 72/360 (20%), Positives = 131/360 (36%), Gaps = 85/360 (23%) Query: 72 ITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIP 131 I A ++I K V +K TP + K +S N T+R G P Sbjct: 69 IPDPAVQSITKNLVALKGPLATP---------IGKGHRSLNLTLRKTFGLFANVRP---- 115 Query: 132 RIPRLVPRWEK-----PIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLK 186 + + ++ +++ R +Y + ++ PG ++ + Sbjct: 116 --AKSIEGFKTTYENVDLVLIRENTEGEYSGIEHIV-CPGVVQSIKLI------------ 160 Query: 187 VYDYKGSGVAMAMYNTDESIEGFAHSSFKLA-IDKKLNLFLSTKNTILKKYDGRFKDIFQ 245 T ++ E +F+ A + + + K+TI + DG F ++ + Sbjct: 161 ---------------TRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAK 205 Query: 246 EVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF---IMALKNYDGDVQSDIVAQGF 302 E+ + E + E LID+ V +++ + + + N GD+ SD+ + Sbjct: 206 ELSK-------EYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLS 258 Query: 303 -GSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRG 361 GSLGL S + F EA HG+ + N A + + L G Sbjct: 259 AGSLGLTPSANIGHKISIF--EAVHGSAPDIAGQ------DKANPTALLLSSVMMLNHMG 310 Query: 362 ELDNTPALCKFANILESATLNTVQQD-GIMTKDLALACGNNERSAYVTTEEFLDAVEKRL 420 ++ A+ +++A L+T+ T DLA TT F +AV KRL Sbjct: 311 LTNH-------ADQIQNAVLSTIASGPENRTGDLA---------GTATTSSFTEAVIKRL 354 >3VMK-A nrPDB Length = 375 Score = 161 bits (406), Expect = 8e-40, Method: Composition-based stats. Identities = 66/383 (17%), Positives = 131/383 (34%), Gaps = 61/383 (15%) Query: 52 DVDLKY--YDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWK 109 D+ ++Y YD+ + D + + + + + + P + + + + Sbjct: 44 DLSIEYSEYDVGGAAIDNHGCPLPEATLKGCEAADAVLFGSVGGPKWEHLPPND--QPER 101 Query: 110 SPNGTIRNILGGTVFREPIVI-------PRIPRLVPRWEKPIIIGRHAHGDQYKATDTLI 162 +R P + + + I+ R G Y Sbjct: 102 GALLPLRGHFELFCNMRPAKLHPGLEHMSPLRSDISEKGFDILCVRELTGGIYFGKPKGR 161 Query: 163 PGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKL 222 G G E + M + + I A +F+ A ++ Sbjct: 162 QGEGENEEAFD------------------------TMRYSRKEIRRIAKIAFESAQGRRK 197 Query: 223 NLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF 282 + K +L +++EV E K + + EH ID+ Q+++ F Sbjct: 198 KVTSVDKANVL-----ACSVLWREVVEEVAK---DYPDVELEHIYIDNATMQLLRRPNEF 249 Query: 283 -IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEE 341 +M N GD+ SD +A GS+GL+ SI + G E A G+ + Sbjct: 250 DVMLCSNLFGDIVSDEIAMLTGSMGLLASISMNSQG-FGMYEPAGGSAPDIAGQG----- 303 Query: 342 TSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNN 401 N +A I + + L +L+ A +E+A ++ DG +T +L + Sbjct: 304 -IANPVAQILSAALLLRHSLKLE------DAALAIEAA-VSKALSDGYLTCEL---LPAS 352 Query: 402 ERSAYVTTEEFLDAVEKRLQKEI 424 ERS +T + D + + + + + Sbjct: 353 ERSQAKSTSQMGDYIAQAIAEGV 375 >3VML-A nrPDB Length = 375 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 58/318 (18%), Positives = 108/318 (33%), Gaps = 57/318 (17%) Query: 115 IRNILGGTVFREPIVI-------PRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGS 167 +R P + + + I+ R G Y G G Sbjct: 107 LRGHFELFCNMRPAKLHPGLEHMSPLRSDISEKGFDILCVRELTGGIYFGKPKGRQGEGE 166 Query: 168 LELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLS 227 E + M + + I A +F+ A ++ + Sbjct: 167 NEEAFD------------------------TMRYSRKEIRRIAKIAFESAQGRRKKVTSV 202 Query: 228 TKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMAL 286 K +L +++EV E K + + EH ID+ Q+++ F +M Sbjct: 203 DKANVL-----ACSVLWREVVEEVAK---DYPDVELEHIYIDNATMQLLRRPNEFDVMLC 254 Query: 287 KNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNS 346 N GD+ SD +A GS+GL+ SI + G E A G+ + N Sbjct: 255 SNLFGDIVSDEIAMLTGSMGLLASISMNSQG-FGMYEPAGGSAPDIAGQG------IANP 307 Query: 347 IASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAY 406 +A I + + L +L+ A +E+A ++ G +T +L +++R Sbjct: 308 VAQILSAALLLRHSLKLE------DAALAIEAA-VSKALNSGYLTGEL---LSSDQRHKA 357 Query: 407 VTTEEFLDAVEKRLQKEI 424 TT + D + ++ + Sbjct: 358 KTTVQMGDFIADAVKAGV 375 >3VMJ-A nrPDB Length = 375 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 55/318 (17%), Positives = 104/318 (32%), Gaps = 57/318 (17%) Query: 115 IRNILGGTVFREPIVIPR-------IPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGS 167 +R P + + + ++ R G Y G G Sbjct: 107 LRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGE 166 Query: 168 LELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLS 227 E + M + I A +F+ A ++ + Sbjct: 167 SEEAFD------------------------TMRYSRREISRIARIAFEAARGRRKKVTSV 202 Query: 228 TKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMAL 286 K +L ++ + +EV + + EH ID+ Q+++ F +M Sbjct: 203 DKANVL-ACSVLWRQVVEEVA-------VDFPDVELEHIYIDNATMQLLRRPDEFDVMLC 254 Query: 287 KNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNS 346 N GD+ SD +A GS+GL++S + G E A G+ K N Sbjct: 255 SNLFGDILSDEIAMLTGSMGLLSSASMNSTGFGL-FEPAGGSAPDIAGKG------IANP 307 Query: 347 IASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAY 406 IA I + + L + + A+ +E A + G +T +L +++R Sbjct: 308 IAQILSAALMLRH------SLKQEEAASAIERA-VTKALNSGYLTGEL---LSSDQRHKA 357 Query: 407 VTTEEFLDAVEKRLQKEI 424 TT + D + ++ + Sbjct: 358 KTTVQMGDFIADAVKAGV 375 >5J32-A nrPDB Length = 403 Score = 155 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 67/407 (16%), Positives = 133/407 (32%), Gaps = 68/407 (16%) Query: 31 GDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCA 90 G E+ I + +++ L ++ + + + + D + ++ A K+ + A Sbjct: 52 GPEVVSIAKNVLQQAGSLEGVEFNFREMPIGGAALDLVGVPLPEETISAAKESDAVLLGA 111 Query: 91 TITPDEARVKEFNLHKMWKSPNG--TIRNILGGTVFREP-------IVIPRIPRLVPRWE 141 K N K + G IR L P + + R V Sbjct: 112 I-----GGYKWDNNEKHLRPEKGLLQIRAALKVFANLRPATVLPQLVDASTLKREVAE-G 165 Query: 142 KPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKV-YDYKGSGVAMAMY 200 +++ R G Y +P+ +K + + G +Y Sbjct: 166 VDLMVVRELTGGIYFG-----------------------EPRGIKTNENGEEVGFNTEVY 202 Query: 201 NTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLG 260 E I+ A +F+ A ++ L K +L+ ++ + E Sbjct: 203 AAHE-IDRIARVAFETARKRRGKLCSVDKANVLEAS-ILWRKRVTALAS-------EYPD 253 Query: 261 IHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKT 319 + H +D+ Q+++ F + N GD+ SD + GS+G++ S ++ G Sbjct: 254 VELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLSDSGPG 313 Query: 320 FESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESA 379 E HG+ + N +A+I + + L K A +E A Sbjct: 314 L-FEPIHGSAPDIAGQ------DKANPLATILSAAMLLKY------GLGEEKAAKRIEDA 360 Query: 380 TLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKS 426 L +G T D+ A E + V K + ++ + Sbjct: 361 VL-VALNNGFRTGDIYSAGTKLVGCK-----EMGEEVLKSVDSQVPA 401 >3ASJ-A nrPDB Length = 334 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 67/360 (18%), Positives = 119/360 (33%), Gaps = 74/360 (20%) Query: 64 SRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTV 123 R TS + ++ E I + A +P F + +R L Sbjct: 45 ERRGTS--VPEETVEKILSCHATLFGAATSPTRKVPGFFGAIRY-------LRRRLDLYA 95 Query: 124 FREPIVIPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQ 183 P +P P ++I R Y + + V Sbjct: 96 NVRPAKSRPVPGSRPG--VDLVIVRENTEGLYVEQERRYLDVAIADAVI----------- 142 Query: 184 TLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDK-KLNLFLSTKNTILKKYDGRFKD 242 + ++ E ++ ++A + + L ++ K +L G F D Sbjct: 143 ------------------SKKASERIGRAALRIAEGRPRKTLHIAHKANVLPLTQGLFLD 184 Query: 243 IFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQG 301 +EV + + ++ + ++D+ Q++ F ++ N GD+ SD+ A Sbjct: 185 TVKEVAK-------DFPLVNVQDIIVDNCAMQLVMRPERFDVIVTTNLLGDILSDLAAGL 237 Query: 302 FGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRG 361 G LGL S + F E HG+ K N A+I + + L G Sbjct: 238 VGGLGLAPSGNIGDTTAVF--EPVHGSAPDIAGKG------IANPTAAILSAAMMLDYLG 289 Query: 362 ELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQ 421 E + A +E A ++ V + G T DL TTE F +AV + L+ Sbjct: 290 E-------KEAAKRVEKA-VDLVLERGPRTPDL---------GGDATTEAFTEAVVEALK 332 >3TY3-A nrPDB Length = 366 Score = 148 bits (373), Expect = 5e-36, Method: Composition-based stats. Identities = 69/385 (17%), Positives = 133/385 (34%), Gaps = 62/385 (16%) Query: 43 KKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAEAIK-KYGVGIKCATITPDEARVKE 101 K KL ++D+ D + + T + + E +K + + A +P Sbjct: 39 KHKLKFDFIDL-----DAGWGTFERTGKALPERTVERLKTECNAALFGAVQSPTHKVA-- 91 Query: 102 FNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVPRWEKPIIIGRHAHGDQYKATDTL 161 + SP +R +G P+ ++I R Y + + Sbjct: 92 -----GYSSPIVALRKKMGLYANVRPVKSLDG---AKGKPVDLVIVRENTECLYVKEERM 143 Query: 162 I---PGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAI 218 + PG E + + S+ + + + + + + I S +I Sbjct: 144 VQNTPGKRVAEAIRRISEEASTKIGKMAFE----------IAKSRQKIRE----SGTYSI 189 Query: 219 DKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKS 278 KK + + K+ ++ DG F++ + I+ + +++D MV ++ + Sbjct: 190 HKKPLVTIIHKSNVMSVTDGLFRESCRH----AQSLDPSYASINVDEQIVDSMVYRLFRE 245 Query: 279 KGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQ 337 F ++ N GD+ SD A GSLGL+ S V + SE HG+ + Sbjct: 246 PECFDVVVAPNLYGDILSDGAASLIGSLGLVPSANVGDN--FVMSEPVHGSAPDIAGRG- 302 Query: 338 KGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALA 397 N +A+ + + L G D A + +A + + ++T DL Sbjct: 303 -----IANPVATFRSVALMLEFMGHQDA-------AADIYTAVDKVLTEGKVLTPDLGGK 350 Query: 398 CGNNERSAYVTTEEFLDAVEKRLQK 422 G T E DAV + Sbjct: 351 SG---------TNEITDAVLANIHN 366 >3BLX-A nrPDB Length = 349 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 62/349 (17%), Positives = 117/349 (33%), Gaps = 70/349 (20%) Query: 75 DAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIV-IPRI 133 +A E++K+ +G+K TP + S N +R L + + Sbjct: 65 EAVESLKRNKIGLKGLWHTPADQ--------TGHGSLNVALRKQLDIYANVALFKSLKGV 116 Query: 134 PRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGS 193 +P + +I+ R ++ + PG +E + Sbjct: 117 KTRIP--DIDLIVIRENTEGEFSGLEHES-VPGVVESLKVM------------------- 154 Query: 194 GVAMAMYNTDESIEGFAHSSFKLAID-KKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQY 252 T E A +F A + ++ K I+K DG F++I E+ + +Y Sbjct: 155 --------TRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEY 206 Query: 253 KSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSI 311 I ++D+ Q + F ++ + G + +I A G GL+ Sbjct: 207 PD------IDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGA 260 Query: 312 LVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCK 371 D FE +RH KG + N A I + + L G L + Sbjct: 261 NFGRDYAVFE------PGSRHVGLDIKG-QNVANPTAMILSSTLMLNHLG-------LNE 306 Query: 372 FANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRL 420 +A + A T+ + T+D+ +T +F + + +L Sbjct: 307 YATRISKAVHETIAEGKHTTRDI---------GGSSSTTDFTNEIINKL 346 >5GRH-B nrPDB Length = 354 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 65/329 (19%), Positives = 115/329 (34%), Gaps = 61/329 (18%) Query: 69 SDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPI 128 ++ ++A AI++ V +K T NL KS N +R L I Sbjct: 57 DEEDIRNAIMAIRRNRVALKGNIET-------NHNLPPSHKSRNNILRTSLDLYANV--I 107 Query: 129 VIPRIPRLVPRWE-KPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKV 187 +P +V R + I+I R +Y + + ++LK+ Sbjct: 108 HCKSLPGVVTRHKDIDILIVRENTEGEYSSLEHESVAG---------------VVESLKI 152 Query: 188 YDYKGSGVAMAMYNTDESIEGFAHSSFKLAID-KKLNLFLSTKNTILKKYDGRFKDIFQE 246 T A +FKLA + + + K I+K DG F +E Sbjct: 153 I-------------TKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCRE 199 Query: 247 VYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSL 305 V I +E+ ++D+ Q++ F +M + N G++ +++ A G Sbjct: 200 VAAR-------YPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGP 252 Query: 306 GLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDN 365 GL+ FE T TR+ K + N A++ A L Sbjct: 253 GLVAGANYGHVYAVFE------TATRNTGKSIAN-KNIANPTATLLASCMMLDHL----- 300 Query: 366 TPALCKFANILESATLNTVQQDGIMTKDL 394 L +A + A L ++ + + T D+ Sbjct: 301 --KLHSYATSIRKAVLASMDNENMHTPDI 327 >5HN5-A nrPDB Length = 353 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 68/366 (18%), Positives = 121/366 (33%), Gaps = 63/366 (17%) Query: 53 VDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPN 112 V +YY+ V+ I ++ E I++ + AT TP F+L ++S Sbjct: 31 VRFEYYEGGVDVFQECGSPIREEDLEEIRRSDAVLFGATTTP-------FDL-PGYRSLI 82 Query: 113 GTIRNILGGTVFREPIVIPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVY 172 T+R LG I P L E I+I R Y ++ G Sbjct: 83 LTLRKELGLYANLRII-----PDLRTGRE--IVIVRENSEGLYFGIGAVVNG-------- 127 Query: 173 KPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTI 232 + +++ T E E A + + A + + K + Sbjct: 128 --------RAVDVRLI-------------TREGAERIARFAVEQAKARGSFITFVHKANV 166 Query: 233 LKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSK-GGFIMALKNYDG 291 L D F+ I +EV + G+ +ID +++++ ++ +N G Sbjct: 167 L-TGDKFFRRIVREVAGEE--------GVEVRDAIIDSFTIKLVRNPWEHGVILSENLFG 217 Query: 292 DVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIF 351 D+ SD+ GS+G++ S F E HG+ K N I +I Sbjct: 218 DILSDLATVHAGSIGIVPSGNYGDGIALF--EPVHGSAPDIAGKG------IANPIGAIL 269 Query: 352 AWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEE 411 + + L G LD + + + L T+D+ E Sbjct: 270 SGAMLLDYLG-LDGSLIRAAVRGYVVNGELTPDMGGRARTEDVVRGIIGEIEDLLSMDEV 328 Query: 412 FLDAVE 417 + D + Sbjct: 329 WRDEIR 334 >1XAD-A nrPDB Length = 345 Score = 134 bits (336), Expect = 9e-32, Method: Composition-based stats. Identities = 62/379 (16%), Positives = 120/379 (31%), Gaps = 73/379 (19%) Query: 51 LDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPD-EARVKEFNLHKMWK 109 L + + + + DA + + + +++ + + P + +E K Sbjct: 32 LGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDQNPRELRPEKGLL 91 Query: 110 SPNGTIRNILGGTVFREPIVI----PRIPRLVPRW--EKPIIIGRHAHGDQYKATDTLIP 163 S IR L P+ + L + +I R G Y Sbjct: 92 S----IRKQLDLFANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGIYFG------ 141 Query: 164 GPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLN 223 +P + A+ + Y +E A +F+ A ++ + Sbjct: 142 ---------EPRGMSEAEAWNTERYSKP-------------EVERVARVAFEAARKRRKH 179 Query: 224 LFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF- 282 + K +L+ + ++ +EV + EH+ +D M +++S F Sbjct: 180 VVSVDKANVLEVGE-FWRKTVEEVGRG-------YPDVALEHQYVDAMAMHLVRSPARFD 231 Query: 283 IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEET 342 ++ N GD+ SD+ + GSLGL+ S + F E HG+ K Sbjct: 232 VVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVF--EPVHGSAPDIAGKG------ 283 Query: 343 STNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNE 402 N A+I + + L L + A +E A + + + Sbjct: 284 IANPTAAILSAAMMLEHAF------GLVELARKVEDAVAKALLE-----------TPPPD 326 Query: 403 RSAYVTTEEFLDAVEKRLQ 421 TE F V + L Sbjct: 327 LGGSAGTEAFTATVLRHLA 345 >1IDM-A nrPDB Length = 343 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 57/315 (18%), Positives = 102/315 (32%), Gaps = 68/315 (21%) Query: 114 TIRNILGGTVFREPI-VIPRIPRLVP-----RWEKPIIIGRHAHGDQYKATDTLIPGPGS 167 ++R P V P + RL P ++I R G Y Sbjct: 90 SLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFG---------- 139 Query: 168 LELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLS 227 +P + A+ + Y +E A +F+ A ++ ++ Sbjct: 140 -----EPRGMSEAEAWNTERYSKP-------------EVERVARVAFEAARKRRKHVVSV 181 Query: 228 TKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMAL 286 K +L+ + ++ +EV + EH+ +D M +++S F ++ Sbjct: 182 DKANVLEVGE-FWRKTVEEVGRG-------YPDVALEHQYVDAMAMHLVRSPARFDVVVT 233 Query: 287 KNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNS 346 N GD+ SD+ + GSLGL+ S + F E HG+ K N Sbjct: 234 GNIFGDILSDLASVLPGSLGLLPSASLGRGTPVF--EPVHGSAPDIAGKG------IANP 285 Query: 347 IASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAY 406 A+I + + L L + A +E A + + + Sbjct: 286 TAAILSAAMMLEHAF------GLVELARKVEDAVAKALLE-----------TPPPDLGGS 328 Query: 407 VTTEEFLDAVEKRLQ 421 TE F V + L Sbjct: 329 AGTEAFTATVLRHLA 343 >3UDO-A nrPDB Length = 361 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 63/264 (23%), Positives = 110/264 (41%), Gaps = 34/264 (12%) Query: 164 GPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTD----ESIEGFAHSSFKLAID 219 P E++ K D + T +Y K + Y+T+ + IE A +F+ A Sbjct: 123 SPLKNEIIQKGVDILCVRELTGGIYFGKQDLGKESAYDTEIYTKKEIERIARIAFESARI 182 Query: 220 KKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSK 279 +K + L K +L +++EV K + I+ E+ +D+ Q++K+ Sbjct: 183 RKKKVHLIDKANVLASS-----ILWREVVANVAK---DYQDINLEYMYVDNAAMQIVKNP 234 Query: 280 GGF-IMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQK 338 F +M N GD+ SD +A GSLGL++S + G E A G+ Sbjct: 235 SIFDVMLCSNLFGDILSDELAAINGSLGLLSSASLNDKGFGL-YEPAGGSAPDIA----- 288 Query: 339 GEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALAC 398 N IA I + + L + + + A +E+A ++ G MTKDL Sbjct: 289 -HLNIANPIAQILSAALMLKYSFKEE------QAAQDIENA-ISLALAQGKMTKDL---- 336 Query: 399 GNNERSAYVTTEEFLDAVEKRLQK 422 +Y+ T+E D + + L++ Sbjct: 337 ---NAKSYLNTDEMGDCILEILKE 357 >3FMX-X nrPDB Length = 364 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 58/346 (16%), Positives = 114/346 (32%), Gaps = 52/346 (15%) Query: 72 ITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIV-I 130 + D AE +K+Y A PD+ + K R V P+ Sbjct: 59 MPDDWAEQLKQYDAIYFGAVGWPDKVPDHISLWGSLLK-----FRREFDQYVNIRPVRLF 113 Query: 131 PRIPRLVPRWE---KPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKV 187 P +P + + ++ R +Y + + Sbjct: 114 PGVPCALANRKVGDIDFVVVRENTEGEYSSL------------------------GGIMF 149 Query: 188 YDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDK-KLNLFLSTKNTILKKYDGRFKDIFQE 246 + + V T ++ +F LA + + ++ +TK+ + + D E Sbjct: 150 ENTENEIVIQESIFTRRGVDRILKYAFDLAEKRERKHVTSATKSNGMAISMPYW-DKRTE 208 Query: 247 VYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMALKNYDGDVQSDIVAQGFGSL 305 A Y + ++ + ID + A+ + F ++ N GD+ SD+ G++ Sbjct: 209 AMAAHYP------HVSWDKQHIDILCARFVLQPERFDVVVASNLFGDILSDLGPACAGTI 262 Query: 306 GLMTSILVTPDGKT-FESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELD 364 G+ S + P+ E HG+ + K N IA I WS L+ Sbjct: 263 GIAPSANLNPERNFPSLFEPVHGSAPDIFGK------NIANPIAMI--WSGALMLEFLGQ 314 Query: 365 NTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTE 410 + + + +A + V DG +T D+ + A ++ Sbjct: 315 GDERYQRAHDDMLNA-IERVIADGSVTPDMGGTLSTQQVGAAISDT 359 >2G4O-A nrPDB Length = 337 Score = 118 bits (295), Expect = 5e-27, Method: Composition-based stats. Identities = 57/346 (16%), Positives = 104/346 (30%), Gaps = 51/346 (14%) Query: 53 VDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPN 112 V YDL AT + + ++ + + A P + + Sbjct: 31 VQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDP------SVPSGVLERGLL 84 Query: 113 GTIRNILGGTVFREPIV-IPRIPRLVPRW-EKPIIIGRHAHGDQYKATDTLIPGPGSLEL 170 +R L + P P + + ++ R Y G++ + Sbjct: 85 LRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVREGTEGPYTG------NGGAIRV 138 Query: 171 VYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKN 230 T NT + +F+ A ++ +L L K Sbjct: 139 GTPNEVATEVSV------------------NTAFGVRRVVADAFERARRRRKHLTLVHKT 180 Query: 231 TILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGF-IMALKNY 289 +L G + EV E Y + ++ +D MI G F ++ N Sbjct: 181 NVLTFAGGLWLRTVDEVGE-CYPD------VEVAYQHVDAATIHMITDPGRFDVIVTDNL 233 Query: 290 DGDVQSDIVAQGFGSLGLMTSILV-TPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIA 348 GD+ +D+ A G +GL S + E HG+ + + A Sbjct: 234 FGDIITDLAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQG------IADPTA 287 Query: 349 SIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDL 394 +I + + L GE D + + A L T + + T D+ Sbjct: 288 AIMSVALLLSHLGEHDAAARV----DRAVEAHLATRGSERLATSDV 329 >1J1W-A nrPDB Length = 741 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 45/115 (39%), Gaps = 3/115 (2%) Query: 276 IKSKGGFIMALKNYDGDVQSDI--VAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHY 333 I+ I N D +D+ + + S +++ + + G FE+ A G+ +H Sbjct: 532 IREGKDTISVTGNVLRDYLTDLFPIMELGTSAKMLSIVPLMSGGGLFET-GAGGSAPKHV 590 Query: 334 RKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDG 388 +++ + +S+ A + L G P A+ L+ AT + + Sbjct: 591 QQFLEEGYLRWDSLGEFLALAASLEHLGNAYKNPKALVLASTLDQATGKILDNNK 645 >2B0T-A nrPDB Length = 738 Score = 38.2 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 19/115 (16%), Positives = 44/115 (38%), Gaps = 3/115 (2%) Query: 276 IKSKGGFIMALKNYDGDVQSDI--VAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHY 333 I+ I N D +D+ + + S +++ + + G FE+ A G+ +H Sbjct: 528 IRRGEDTISVTGNVLRDYNTDLFPILELGTSAKMLSVVPLMAGGGLFET-GAGGSAPKHV 586 Query: 334 RKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDG 388 ++ Q+ +S+ A + + A+ L+ AT + ++ Sbjct: 587 QQVQEENHLRWDSLGEFLALAESFRHELNNNGNTKAGVLADALDKATEKLLNEEK 641 >5Z16-A nrPDB Length = 751 Score = 35.9 bits (81), Expect = 0.037, Method: Composition-based stats. Identities = 22/117 (18%), Positives = 46/117 (39%), Gaps = 6/117 (5%) Query: 283 IMALKNYDGDVQSDI--VAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGE 340 I N D +D+ + + S +++ + + G +E+ A G+ +H ++ + Sbjct: 548 ISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYET-GAGGSAPKHVQQLVEEN 606 Query: 341 ETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGI---MTKDL 394 +S+ A + L + G +N A L+ AT + D T +L Sbjct: 607 HLRWDSLGEFLALAVSLEEMGIKENNARTKLLAKTLDEATGKLLDNDKSPSRRTGEL 663 >4ZDA-A nrPDB Length = 767 Score = 35.2 bits (79), Expect = 0.052, Method: Composition-based stats. Identities = 21/117 (17%), Positives = 45/117 (38%), Gaps = 6/117 (5%) Query: 283 IMALKNYDGDVQSDI--VAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGE 340 I A N D +D+ + + S +++ + + G +E+ A G+ +H + + Sbjct: 542 IAATGNILRDYLTDLFPILELGTSAKMLSIVPLMAGGGLYET-GAGGSAPKHVHQLVEEN 600 Query: 341 ETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGI---MTKDL 394 +S+ A L G A L++AT ++++ T +L Sbjct: 601 HLRWDSLGEFLALGASLEDMGNKTGNEKAKVLAKALDTATGKLLEENKSPSRRTGEL 657 Score = 29.4 bits (64), Expect = 3.6, Method: Composition-based stats. Identities = 32/188 (17%), Positives = 70/188 (37%), Gaps = 15/188 (7%) Query: 93 TPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRI----PRLVPRWEKP--III 146 T DE ++K+ + + N +R G + R P + P + W + + Sbjct: 118 TDDEKKIKDRYAKILGSAVNPVLRE--GNSDRRAPKAVKEYARKHPHSMGEWSQASRTHV 175 Query: 147 GRHAHGDQYKATDTL-IPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDES 205 GD Y ++ + +++V K + + +MY + ++ Sbjct: 176 ATMKTGDFYHGEKSMTLDRDRRVKMVLKTKSGEEIVLKPE--VKLDAGDIIDSMYMSKKA 233 Query: 206 IEGFAHSSFKLAIDKKLNLFLSTKNTILKKYD----GRFKDIFQEVYEAQYKSKFEQLGI 261 + F + A + L K T++K G +F + A+++ F++LG+ Sbjct: 234 LIAFYEEQIEDAYKTGVMFSLHVKATMMKVSHPIVFGHAVKVFYKDAFAKHEKLFDELGV 293 Query: 262 HYEHRLID 269 + + L D Sbjct: 294 NVNNGLSD 301 >6G3U-A nrPDB Length = 737 Score = 32.9 bits (73), Expect = 0.30, Method: Composition-based stats. Identities = 17/120 (14%), Positives = 43/120 (35%), Gaps = 3/120 (2%) Query: 271 MVAQMIKSKGGFIMALKNYDGDVQSDI--VAQGFGSLGLMTSILVTPDGKTFESEAAHGT 328 + + + I N D +D+ + + S +++ + + G +E+ A G+ Sbjct: 523 VSMERLIRGKDTISVTGNVLRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYET-GAGGS 581 Query: 329 VTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDG 388 +H ++ + +S+ A + L + G L+ AT + + Sbjct: 582 APKHVQQLVEENYLRWDSLGEFLALAVSLEETGIKTGNAKAKLLGKALDEATGKLLDNNK 641 >1XDT-T nrPDB Length = 535 Score = 31.7 bits (70), Expect = 0.61, Method: Composition-based stats. Identities = 49/318 (15%), Positives = 96/318 (30%), Gaps = 53/318 (16%) Query: 133 IPRLVPRWEKPIIIGRHAHGDQYKA--------------TDTLIPGPGSLELVYKPSDPT 178 + + +KP + + D +K D P G V K + P Sbjct: 28 VDSIQKGIQKPKSGTQGNYDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPG 87 Query: 179 TAQPQTLKVYDYKGSGVAMAMY---------NTDESIEGFAHSSFKLAIDKKLNLFLSTK 229 + LKV + + + + T+E I+ F + ++ + L + Sbjct: 88 LTKVLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLS----LPFAEG 143 Query: 230 NTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVA-QMIKSKGGFIMALKN 288 ++ ++ + + V + G + + A ++ G ++ N Sbjct: 144 SSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQACAGNRVRRSVGSSLSCIN 203 Query: 289 YDGDVQSDIVAQGFGSL----------GLMTSILVTPDGKTFESEAAHGTVTRHYRKYQK 338 D DV D SL + V+ + E H T H + Sbjct: 204 LDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTALEHPELSEL 263 Query: 339 GEETSTNSI---ASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLA 395 T TN + A+ AW+ + + A+ LE T G + Sbjct: 264 KTVTGTNPVFAGANYAAWAVNV-------AQVIDSETADNLEKTTAALSILPG-----IG 311 Query: 396 LACGNNERSAYVTTEEFL 413 G + + + TEE + Sbjct: 312 SVMGIADGAVHHNTEEIV 329 >5KVU-A nrPDB Length = 745 Score = 31.7 bits (70), Expect = 0.62, Method: Composition-based stats. Identities = 24/150 (16%), Positives = 52/150 (34%), Gaps = 6/150 (4%) Query: 283 IMALKNYDGDVQSDI--VAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGE 340 I A N D +D+ + + S +++ + + G +E+ A G+ +H ++ + Sbjct: 542 IAATGNILRDYLTDLFPILELGTSAKMLSVVPLMAGGGMYET-GAGGSAPKHVKQLVEEN 600 Query: 341 ETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGI---MTKDLALA 397 +S+ A G G L++A + D T +L Sbjct: 601 HLRWDSLGEFLALGAGFEDIGIKTGNERAKLLGKTLDAAIGKLLDNDKSPSRKTGELDNR 660 Query: 398 CGNNERSAYVTTEEFLDAVEKRLQKEIKSI 427 + Y E +++L + S+ Sbjct: 661 GSQFYLAMYWAQELAAQTDDQQLAEHFASL 690 >4OM9-A nrPDB Length = 966 Score = 31.7 bits (70), Expect = 0.67, Method: Composition-based stats. Identities = 26/169 (15%), Positives = 51/169 (30%), Gaps = 8/169 (4%) Query: 53 VDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVK-EFNLHKMWKSP 111 +DL ++ + + AT T + K+ + + V L + Sbjct: 431 LDLNGHNQTFKKIAATDSGTTITNSNTTKESVLSVNNQNNYIYHGNVDGNVRLEHHLDTK 490 Query: 112 NGTIRNILGGTVFREPIVIPRIPRLVPRWEKPIIIGR----HAHGDQYKATDTLI---PG 164 R IL G + I I P ++ I R + + D + Sbjct: 491 QDNARLILDGDIQANSISIKNAPLVMQGHATDHAIFRTTKTNNCPEFLCGVDWVTRIKNA 550 Query: 165 PGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSS 213 S+ K + + Q L D++ N ++S A ++ Sbjct: 551 ENSVNQKNKTTYKSNNQVSDLSQPDWETRKFRFDNLNIEDSSLSIARNA 599 >5L2E-A nrPDB Length = 688 Score = 29.4 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 19/67 (28%), Positives = 27/67 (40%), Gaps = 5/67 (7%) Query: 50 YLDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWK 109 Y+ D KY D T + + + K+ +GI TITPD V +F M Sbjct: 468 YVAPDHKY---GSPQEDGTWNGLVGELV--FKRADIGISALTITPDRENVVDFTTRYMDY 522 Query: 110 SPNGTIR 116 S +R Sbjct: 523 SVGVLLR 529 >5CC2-A nrPDB Length = 265 Score = 29.4 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 19/67 (28%), Positives = 27/67 (40%), Gaps = 5/67 (7%) Query: 50 YLDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWK 109 Y+ D KY D T + + + K+ +GI TITPD V +F M Sbjct: 51 YVAPDHKY---GSPQEDGTWNGLVGELV--FKRADIGISALTITPDRENVVDFTTRYMDY 105 Query: 110 SPNGTIR 116 S +R Sbjct: 106 SVGVLLR 112 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.123 0.306 Lambda K H 0.267 0.0374 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,313,371 Number of Sequences: 36641 Number of extensions: 559667 Number of successful extensions: 1869 Number of sequences better than 10.0: 53 Number of HSP's better than 10.0 without gapping: 64 Number of HSP's successfully gapped in prelim test: 43 Number of HSP's that attempted gapping in prelim test: 1586 Number of HSP's gapped (non-prelim): 121 length of query: 428 length of database: 10,336,785 effective HSP length: 100 effective length of query: 328 effective length of database: 6,672,685 effective search space: 2188640680 effective search space used: 2188640680 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 60 (27.9 bits)