BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P21793 (360 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1XCD-A nrPDB 673 0.0 2FT3-A nrPDB 382 e-106 5MX0-A nrPDB 107 6e-24 5YQ5-A nrPDB 107 8e-24 5LFN-A nrPDB 96 3e-20 5ZSN-B nrPDB 84 7e-17 6GFF-I nrPDB 82 5e-16 2XOT-A nrPDB 80 2e-15 4R08-A nrPDB 78 7e-15 4QDH-A nrPDB 74 8e-14 2V9T-B nrPDB 73 2e-13 3CIG-A nrPDB 70 1e-12 3ULU-A nrPDB 70 2e-12 4R6F-A nrPDB 67 1e-11 5Y31-B nrPDB 66 2e-11 5Y3K-A nrPDB 66 3e-11 2Z80-A nrPDB 65 4e-11 2Z7X-A nrPDB 65 5e-11 6HLU-A nrPDB 64 1e-10 3WPI-A nrPDB 60 2e-09 3J0A-A nrPDB 59 4e-09 5D3I-A nrPDB 57 1e-08 3A7C-A nrPDB 57 1e-08 3V44-A nrPDB 56 3e-08 5GY2-A nrPDB 54 1e-07 4PUF-A nrPDB 53 2e-07 3B2D-A nrPDB 51 7e-07 5Y3M-A nrPDB 51 8e-07 3RG1-A nrPDB 50 1e-06 4AY9-X nrPDB 49 3e-06 3A79-B nrPDB 49 4e-06 2Z7X-B nrPDB 49 4e-06 5XJX-C nrPDB 48 6e-06 1XWD-C nrPDB 47 1e-05 1JL5-A nrPDB 47 1e-05 3T6Q-A nrPDB 46 2e-05 6O00-A nrPDB 44 1e-04 3G04-C nrPDB 42 3e-04 1M9S-A nrPDB 41 7e-04 6HKW-A nrPDB 39 0.004 3JB9-j nrPDB 37 0.011 3G06-A nrPDB 37 0.017 4PBV-A nrPDB 35 0.036 6ICZ-o nrPDB 35 0.062 5LJ5-W nrPDB 33 0.14 3JCM-G nrPDB 33 0.22 2Q4G-W nrPDB 32 0.36 2BNH-A nrPDB 32 0.50 4ECN-A nrPDB 32 0.58 6EZB-A nrPDB 32 0.62 4PBW-B nrPDB 31 0.77 2YKV-A nrPDB 30 1.2 1DCE-A nrPDB 30 1.6 2QM3-A nrPDB 29 2.7 1K05-A nrPDB 28 5.8 3TSR-E nrPDB 28 6.5 5KH1-A nrPDB 28 6.9 6ACN-A nrPDB 28 8.0 3VCY-A nrPDB 27 9.7 >1XCD-A nrPDB Length = 329 Score = 673 bits (1736), Expect = 0.0, Method: Compositional matrix adjust. Identities = 329/329 (100%), Positives = 329/329 (100%) Query: 31 DEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQ 90 DEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQ Sbjct: 1 DEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQ 60 Query: 91 NNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMP 150 NNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMP Sbjct: 61 NNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMP 120 Query: 151 KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIAD 210 KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIAD Sbjct: 121 KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIAD 180 Query: 211 TNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTP 270 TNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTP Sbjct: 181 TNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTP 240 Query: 271 HLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSL 330 HLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSL Sbjct: 241 HLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSL 300 Query: 331 FSNPVQYWEIQPSTFRCVYVRAAVQLGNY 359 FSNPVQYWEIQPSTFRCVYVRAAVQLGNY Sbjct: 301 FSNPVQYWEIQPSTFRCVYVRAAVQLGNY 329 >2FT3-A nrPDB Length = 332 Score = 382 bits (981), Expect = e-106, Method: Compositional matrix adjust. Identities = 184/332 (55%), Positives = 243/332 (73%), Gaps = 2/332 (0%) Query: 30 EDEASGIGPEEHFPEVPEIEPM-GPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLD 88 ++EASG P++ + P +CPF C CHLRVVQCSDLGL+ VPK++ PDT LLD Sbjct: 1 DEEASGAETTSGIPDLDSLPPTYSAMCPFGCHCHLRVVQCSDLGLKAVPKEISPDTTLLD 60 Query: 89 LQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEK 148 LQNN I+E++ DFK L++L+ L+L+NNKISKI AF+PL KL++LY+SKN L E+P Sbjct: 61 LQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPN 120 Query: 149 MPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRI 208 +P +L ELR+H+N I KV K VF+GL M +E+G NPL++SG E GAF G+K L+Y+RI Sbjct: 121 LPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLK-LNYLRI 179 Query: 209 ADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLAN 268 ++ +T IP+ LP +L ELHLD NKI ++ L + L +LGL N I ++NGSL+ Sbjct: 180 SEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSF 239 Query: 269 TPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGV 328 P LRELHL+NNKL +VP GL D K +QVVYLH NNI+ +G NDFCP G+ K+A Y+G+ Sbjct: 240 LPTLRELHLDNNKLSRVPAGLPDLKLLQVVYLHTNNITKVGVNDFCPVGFGVKRAYYNGI 299 Query: 329 SLFSNPVQYWEIQPSTFRCVYVRAAVQLGNYK 360 SLF+NPV YWE+QP+TFRCV R A+Q GNYK Sbjct: 300 SLFNNPVPYWEVQPATFRCVTDRLAIQFGNYK 331 >5MX0-A nrPDB Length = 362 Score = 107 bits (268), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 76/268 (28%), Positives = 137/268 (51%), Gaps = 17/268 (6%) Query: 55 CPFRCQC---HLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTL 111 CP C C + C + L+ +P +P + QNN+IT I++G F N L + Sbjct: 62 CPQECDCPPNFPTAMYCDNRNLKYLPF-VPSRMKYVYFQNNQITSIQEGVFDNATGLLWI 120 Query: 112 ILINNKIS--KISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKS 169 L N+I+ K+ F+ L LERLYL N L +P +P++L+EL + N+I++V + Sbjct: 121 ALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNN 180 Query: 170 VFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHL 229 GL + + L N ++ G + +G++ L + ++ ++ +P GLP +L +L++ Sbjct: 181 ALEGLENLTALYLQHNEIQEVG---SSMRGLRSLILLDLSYNHLRKVPDGLPSALEQLYM 237 Query: 230 DGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNN---NKLVKVP 286 + N + V + +G L + LS NS++ +NG +NT + L + N+L K+P Sbjct: 238 EHNNVYTVPDSYFRGAPKLLYVRLSHNSLT--NNGLASNTFNSSSLLELDLSYNQLQKIP 295 Query: 287 GGLADHKYIQVVYLHNNNISAIGSNDFC 314 + ++ +YL N I+ + FC Sbjct: 296 PVNTN---LENLYLQGNRINEFSISSFC 320 >5YQ5-A nrPDB Length = 430 Score = 107 bits (267), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 81/269 (30%), Positives = 134/269 (49%), Gaps = 16/269 (5%) Query: 55 CPFRCQCHLRV---VQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTL 111 C C C + C + L+ +P ++P L LQ N+I + F N +L + Sbjct: 60 CVSECFCPTNFPSSMYCDNRKLKTIP-NIPMHIQQLYLQFNEIEAVTANSFINATHLKEI 118 Query: 112 ILINNKI--SKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKS 169 L +NKI KI G FA L L +L+L N L+E P +PK+L+ L + NEI+K++ + Sbjct: 119 NLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNNLEEFPFPLPKSLERLLLGYNEISKLQTN 178 Query: 170 VFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHL 229 +GL + +++L N L S +++ F M+KL + + + ++P GLP SL L L Sbjct: 179 AMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPGLPSSLMYLSL 238 Query: 230 DGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVK---VP 286 + N I+ + L L L +S N + + ++ N P++ EL + +NKL + +P Sbjct: 239 ENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIP-YNIFNLPNIVELSVGHNKLKQAFYIP 297 Query: 287 GGLADHKYIQVVYLHNNNISAIGSNDFCP 315 L + +YL NN I + CP Sbjct: 298 RNL------EHLYLQNNEIEKMNLTVMCP 320 >5LFN-A nrPDB Length = 337 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 79/288 (27%), Positives = 134/288 (46%), Gaps = 55/288 (19%) Query: 55 CPFRCQCH--LRVVQCSDLGLEKVPKDLPPDTALLDLQNN-------------------- 92 CP C CH L+ V C +GL+K+PK + T LL+LQ N Sbjct: 1 CPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLH 59 Query: 93 ----KITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEK 148 +I E+ G F+ LK L L L +N I + GAF L +L LYL N++ ELP Sbjct: 60 LQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELP-- 117 Query: 149 MPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRI 208 + + + L + +++L N ++ + GAFQG K L ++ + Sbjct: 118 -------------------RGLLSPLVNLFILQLNNNKIRE--LRAGAFQGAKDLRWLYL 156 Query: 209 ADTNITTIPQGL---PPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAV-DNG 264 ++ ++++ G +L + H+D N+++ +A+L L + +L LS N + ++ DN Sbjct: 157 SENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNA 216 Query: 265 SLANTPHLRELHLNNNKLVKVP-GGLADHKYIQVVYLHNNNISAIGSN 311 + +L L L+N L K G ++ V+L NN ++ + SN Sbjct: 217 FQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSN 264 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 50/93 (53%), Gaps = 1/93 (1%) Query: 222 PSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNK 281 P+L LHL +I +V A + +GL L L LS N I + G+ + L L+L++NK Sbjct: 53 PNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNK 112 Query: 282 LVKVPGGLADHKY-IQVVYLHNNNISAIGSNDF 313 + ++P GL + ++ L+NN I + + F Sbjct: 113 VTELPRGLLSPLVNLFILQLNNNKIRELRAGAF 145 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 23/65 (35%), Positives = 35/65 (53%), Gaps = 1/65 (1%) Query: 87 LDLQNNKITEIKDGDFKNL-KNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKEL 145 L L +N + I D F++ + L TL L N + K S GAF + L+ ++L N+L +L Sbjct: 202 LKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQL 261 Query: 146 PEKMP 150 P P Sbjct: 262 PSNFP 266 >5ZSN-B nrPDB Length = 823 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 80/265 (30%), Positives = 122/265 (46%), Gaps = 28/265 (10%) Query: 65 VVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKIS----- 119 +V C+D L ++P +P +T L L N I +I F L +L + N + Sbjct: 26 IVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLVHLVEIDFRCNCVPIRLGS 85 Query: 120 ---------KISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSV 170 +I P +F+ L L+ LYL NQL E+P+ +P +LQ L + N I +RK Sbjct: 86 KSNMCPRRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQ 145 Query: 171 FNGLNQMIVVELGTNPLK------SSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSL 224 L + ++ LG N S IE AF + KL + + D N+TT+P LP +L Sbjct: 146 LTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLPSTL 205 Query: 225 TELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVK 284 TEL+L N I ++ LN L L LS N N TP NN ++ Sbjct: 206 TELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCY-NAPFPCTP------CKNNSPLQ 258 Query: 285 VPGGLADH-KYIQVVYLHNNNISAI 308 +P D ++V+ LH+N++ + Sbjct: 259 IPVNAFDALTELKVLRLHSNSLQHV 283 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 66/252 (26%), Positives = 109/252 (43%), Gaps = 31/252 (12%) Query: 87 LDLQNNKITEIKDG-DFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKEL 145 L+L N I++ +G +F+ L L L NN++ + AF L KLE L +S N Sbjct: 500 LNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELRKLEVLDISSNSHYFQ 559 Query: 146 PE---------KMPKTLQELRVHENEITK----------VRKSVFNGLNQMIVVELGTNP 186 E K K LQ+L +++N+I+ +R F G + ++ G N Sbjct: 560 SEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWRDGDNR 619 Query: 187 LKSSGIENGAFQGMKKLSYIRIADTNITTIPQG----LPPSLTELHLDGNKITKVDAASL 242 F+ + KL + I+ +++ +P G +PP+L L L N + L Sbjct: 620 YLQ------LFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKL 673 Query: 243 KGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGG-LADHKYIQVVYLH 301 + L NL L LS N ++ V + L+ L L NN++ + L D ++ + L Sbjct: 674 RYLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLS 733 Query: 302 NNNISAIGSNDF 313 +N I I F Sbjct: 734 SNKIQMIQKTSF 745 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 73/270 (27%), Positives = 106/270 (39%), Gaps = 49/270 (18%) Query: 39 EEHFPEVPEIE--PMGPVCPFRCQCH---------------LRVVQCSDLGLEKVPKDLP 81 +E E+ IE +G C +R C+ L+V+ D + VP LP Sbjct: 143 KEQLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLP 202 Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILI-----------------NNKISKISPG 124 L L NN I EI++ DF NL L L L NN +I Sbjct: 203 STLTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPCKNNSPLQIPVN 262 Query: 125 AFAPLVKLERLYLSKNQLKELPEKMPK---TLQELRVHENEITKV--RKSVFNGLNQMIV 179 AF L +L+ L L N L+ +P + K LQEL + +N + K + L +I Sbjct: 263 AFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFLAKEIGDAKFLHFLPNLIQ 322 Query: 180 VELGTN----PLKSSGIENGAFQGMKKLSYIRIADTNITTIPQ-GLPP-----SLTELHL 229 ++L N ++S + AF +K L +RI + L P +L L L Sbjct: 323 LDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFQLSPLHNLQNLEVLDL 382 Query: 230 DGNKITKVDAASLKGLNNLAKLGLSFNSIS 259 N I + + K L + LS N IS Sbjct: 383 GTNFIKIANLSMFKQFKRLKVIDLSVNKIS 412 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 86/213 (40%), Gaps = 36/213 (16%) Query: 141 QLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTN--PLKSSGIEN---- 194 L E+P +P L + N I + + F+ L ++ ++ N P++ N Sbjct: 33 HLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLVHLVEIDFRCNCVPIRLGSKSNMCPR 92 Query: 195 ------GAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNL 248 +F G+ L + + + IPQGLPPSL L L+ N I + L L N+ Sbjct: 93 RLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQLTELANI 152 Query: 249 AKLGLSFNSIS--------AVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYL 300 L L N +++ + N L+ L L +N + VP L + +YL Sbjct: 153 EILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLPST--LTELYL 210 Query: 301 HNNNISAIGSNDF--------------CPPGYN 319 +NN I+ I +DF CP YN Sbjct: 211 YNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYN 243 Score = 32.3 bits (72), Expect = 0.31, Method: Compositional matrix adjust. Identities = 30/111 (27%), Positives = 53/111 (47%), Gaps = 5/111 (4%) Query: 80 LPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSK 139 +PP+ L L N + + LKNL TL L +N+++ + L+ L L Sbjct: 651 MPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKN 710 Query: 140 NQLKELPEKMPKTLQELR---VHENEITKVRKSVF--NGLNQMIVVELGTN 185 NQ++ L + + +LR + N+I ++K+ F N LN + ++ L N Sbjct: 711 NQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHN 761 >6GFF-I nrPDB Length = 618 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 77/262 (29%), Positives = 118/262 (45%), Gaps = 37/262 (14%) Query: 59 CQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKI 118 C+ + V C LGL +VP LPPDT LDL N++ I L L L N+I Sbjct: 7 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 66 Query: 119 SKISPGAFAPLVKLERLYLSKNQL----------------------------KELPEKM- 149 S + PGAF L LE L L+ N+L L E++ Sbjct: 67 SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 126 Query: 150 --PKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIR 207 +L L + EN +T++ + F + + ++L +N L IE+GAF+G+ +L+++ Sbjct: 127 GEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMD--IEDGAFEGLPRLTHLN 184 Query: 208 IADTNITTIPQGLPPSLTELHLDGNKITKVDAASL-KGLNNLAKLGLSFNSISAVDNGSL 266 ++ ++T I L L L N I AS + L L L N + + L Sbjct: 185 LSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--L 242 Query: 267 ANTPHLRELHLNNNKLVKVPGG 288 A P L L+L+NN L+++P G Sbjct: 243 AALPRLIYLNLSNN-LIRLPTG 263 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 59/230 (25%), Positives = 97/230 (42%), Gaps = 46/230 (20%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 P LLDL +N + ++ G + L +L TL+L N + + P FA L L+RL L N+ Sbjct: 344 PCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNR 402 Query: 142 LKEL---PEKMPK---------TLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKS 189 + E P +L+ L + +NEI +R F + ++L +NP Sbjct: 403 VSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLH-TPLTELDLSSNP--- 458 Query: 190 SGIE--NGAFQGMKK------------------------LSYIRIADTNITTIPQGLPP- 222 G+E GA G++ L + +A+ ++ +P Sbjct: 459 -GLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAV 517 Query: 223 SLTELHLDGNKITKVDAASLKGL-NNLAKLGLSFNSISAVDNGSLANTPH 271 SL L L N + + +++ GL +L +L L N +S NG LA H Sbjct: 518 SLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLH 567 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 66/234 (28%), Positives = 98/234 (41%), Gaps = 14/234 (5%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLK--E 144 LDL N+I I D ++L +L L L N + L L L LS N L+ E Sbjct: 301 LDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLE 360 Query: 145 LPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSG--IENG-----AF 197 L + +L+ L + N + + F L + + L N + G E G AF Sbjct: 361 LGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAF 420 Query: 198 QGMKKLSYIRIADTNITTIPQG--LPPSLTELHLDGNKITKVDAASLKGLN-NLAKLGLS 254 G+ L + + D I + G L LTEL L N +V +L GL +L L L Sbjct: 421 SGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQ 480 Query: 255 FNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAI 308 N + V L L+ L+L N+L +P ++V+ L NN+ S + Sbjct: 481 GNGL-MVLQVDLPCFICLKRLNLAENRLSHLP-AWTQAVSLEVLDLRNNSFSLL 532 >2XOT-A nrPDB Length = 361 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/203 (32%), Positives = 92/203 (45%), Gaps = 24/203 (11%) Query: 55 CPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIK-DGDFKNLKNLHTLIL 113 CP C C ++ CS L VP+ LP TALLDL +N ++ ++ + L NLH+L+L Sbjct: 12 CPANCLCASNILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLL 71 Query: 114 INNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRV---HENEITKVRKSV 170 +N ++ IS AF P+ L L LS N L L E + LQ L V + N I V ++ Sbjct: 72 SHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNA 131 Query: 171 FNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLD 230 F + Q+ + L N + +E I D N P L L L Sbjct: 132 FEDMAQLQKLYLSQNQISRFPVE-------------LIKDGNKL-------PKLMLLDLS 171 Query: 231 GNKITKVDAASLKGLNNLAKLGL 253 NK+ K+ L+ L K GL Sbjct: 172 SNKLKKLPLTDLQKLPAWVKNGL 194 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 53/183 (28%), Positives = 85/183 (46%), Gaps = 20/183 (10%) Query: 135 LYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVF-NGLNQMIVVELGTNPLKSSGIE 193 L SK QL +P+ +P L + N ++++R L + + L N L + I Sbjct: 23 LSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHL--NFIS 80 Query: 194 NGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELH---LDGNKITKVDAASLKGLNNLAK 250 + AF + L Y+ ++ ++ T+ + L L L L N I VD + + + L K Sbjct: 81 SEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQK 140 Query: 251 LGLSFNSISA-----VDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQV-----VYL 300 L LS N IS + +G+ P L L L++NKL K+P L D + + +YL Sbjct: 141 LYLSQNQISRFPVELIKDGN--KLPKLMLLDLSSNKLKKLP--LTDLQKLPAWVKNGLYL 196 Query: 301 HNN 303 HNN Sbjct: 197 HNN 199 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 31/100 (31%), Positives = 54/100 (54%), Gaps = 2/100 (2%) Query: 216 IPQGLPPSLTELHLDGNKITKVDAA-SLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRE 274 +PQ LP L L N ++++ A + L NL L LS N ++ + + + P+LR Sbjct: 33 VPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRY 92 Query: 275 LHLNNNKLVKVPGGL-ADHKYIQVVYLHNNNISAIGSNDF 313 L L++N L + L +D + ++V+ L+NN+I + N F Sbjct: 93 LDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAF 132 >4R08-A nrPDB Length = 811 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 72/261 (27%), Positives = 119/261 (45%), Gaps = 38/261 (14%) Query: 65 VVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLIL----------- 113 + +CS+ L++VP+ + LDL +N IT I + F+ L+NL + L Sbjct: 24 IAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNG 83 Query: 114 ---INNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSV 170 I + I+ GAF L L L L NQL ++P +P++L EL + +N I + K Sbjct: 84 NPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEG 143 Query: 171 FNGLNQMIVVELGTNPL-----KSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLT 225 + L + + L N + + IE+G F+ + L + ++ +++ +P LP SL Sbjct: 144 ISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLR 203 Query: 226 ELHLDGNKITKVDAASLKGLNNLAKLGLSFN------------------SISAVDNGSLA 267 +L L +I + KGL NL L LS N SI+ +D + Sbjct: 204 KLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASIN-IDRFAFQ 262 Query: 268 NTPHLRELHLNNNKLVKVPGG 288 N LR L+L++ L K+ Sbjct: 263 NLTQLRYLNLSSTSLRKINAA 283 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 65/224 (29%), Positives = 94/224 (41%), Gaps = 27/224 (12%) Query: 62 HLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINN----- 116 +LR + D L ++P LP L L N I I L NL L L N Sbjct: 104 NLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNK 163 Query: 117 --KISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGL 174 + + I G F L LE L LS N L +P K+P +L++L + +I + + F GL Sbjct: 164 VCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGL 223 Query: 175 NQMIVVELGTN-------PL--------KSSGIENGAFQGMKKLSYIRIADTNITTIPQG 219 + +++L N P S I+ AFQ + +L Y+ ++ T++ I Sbjct: 224 INLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAA 283 Query: 220 L---PPSLTELHLDGNKITK--VDAASLKGLNNLAKLGLSFNSI 258 P L L L+ N + A L L L L LSFN I Sbjct: 284 WFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYI 327 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 59/230 (25%), Positives = 99/230 (43%), Gaps = 25/230 (10%) Query: 82 PDTALLDLQNNKITEIKDG-DFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKN 140 PD A L+L N ++ G +F + ++ L L NN++ + A L LE L LS N Sbjct: 483 PDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 542 Query: 141 ----QLKELPEKMP--KTLQELRV----HENEITKVRKSVFNGLNQMIVVELGTNPLKSS 190 ++ + + + L+V H N T K L +VEL + + Sbjct: 543 SHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKY---NLESKSLVELVFSGNRLD 599 Query: 191 GIEN-------GAFQGMKKLSYIRIADTNITTIPQ----GLPPSLTELHLDGNKITKVDA 239 + N F+G+K L+ + ++ + IP LP SLTELH++ N + + Sbjct: 600 ILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNW 659 Query: 240 ASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGL 289 L+ L L L N + + + T LR L L++N++ +P G Sbjct: 660 TLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGF 709 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 29/85 (34%), Positives = 41/85 (48%), Gaps = 5/85 (5%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 P LLDL+ NK+ + D +L TL+L +N+IS + G + + L+ L LS N Sbjct: 666 PRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNL 725 Query: 142 LKE-----LPEKMPKTLQELRVHEN 161 LK L K L L +H N Sbjct: 726 LKTINKSALETKTTTKLSMLELHGN 750 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 44/196 (22%), Positives = 82/196 (41%), Gaps = 27/196 (13%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILIN---NKISKISPGAFAPLVKLERLYLSKNQLK 143 L L+ E+++ DF+ L L L IN N I +I F LE +YLS+N++ Sbjct: 350 LHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRIS 409 Query: 144 ELPEKMPKTLQELRVHENEITKVRK--------SVFNGLNQMIV----------VELGTN 185 L + ++ + I K R S F + ++ ++L N Sbjct: 410 PLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLN 469 Query: 186 PLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLP----PSLTELHLDGNKITKVDAAS 241 + G F+ + ++ + ++ + + G P + L L N++ +A++ Sbjct: 470 SIFFIG--PNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASA 527 Query: 242 LKGLNNLAKLGLSFNS 257 L L++L L LS+NS Sbjct: 528 LTELSDLEVLDLSYNS 543 >4QDH-A nrPDB Length = 438 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 68/226 (30%), Positives = 106/226 (46%), Gaps = 16/226 (7%) Query: 49 EPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNL 108 +P G CP RC C ++C+ GL VP +P L+L++NK+ + G F L L Sbjct: 2 DPGGKACPSRCSCSGTEIRCNSKGLTSVPTGIPSSATRLELESNKLQSLPHGVFDKLTQL 61 Query: 109 HTLILINNKISKISPGAFAPLVKLERLYLSKNQLKEL---PEKMPKT-LQELRVHENEIT 164 L L N + I P F L +L+ L LS N + + + +P T LQ L + N++ Sbjct: 62 TKLSLSRNNLVTIKPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLD 121 Query: 165 KVRKSVFNGLNQMIVVELGTN--PLKSSGI-ENGAF-QGMKKLSYIRIADTNI-TTIPQG 219 F+ L Q+ ++L N P GI N +F + L + +A +I T + Sbjct: 122 LYHWKSFSELPQLQALDLSYNSQPFSMKGIGHNFSFVTHLSMLQSLSLAHNDIHTRVSSH 181 Query: 220 L-PPSLTELHLDGNKITKV-DAASL-----KGLNNLAKLGLSFNSI 258 L S+ L GN + ++ D L +GL+ L KL LS N++ Sbjct: 182 LNSNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNL 227 >2V9T-B nrPDB Length = 220 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 50/158 (31%), Positives = 81/158 (51%), Gaps = 5/158 (3%) Query: 55 CPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILI 114 CP C C +V C GL ++P +LP + L+ N I I G F K L + L Sbjct: 5 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 64 Query: 115 NNKISKISPGAFAPLVKLERLYLSKNQLKELPEKM---PKTLQELRVHENEITKVRKSVF 171 NN+IS+++P AF L L L L N++ ELP+ + +LQ L ++ N+I +R F Sbjct: 65 NNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAF 124 Query: 172 NGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIA 209 L+ + ++ L N L++ I G F ++ + + +A Sbjct: 125 QDLHNLNLLSLYDNKLQT--IAKGTFSPLRAIQTMHLA 160 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 46/172 (26%), Positives = 82/172 (47%), Gaps = 10/172 (5%) Query: 142 LKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMK 201 L E+P +P+T+ E+R+ +N I + F+ ++ ++L N + S + AFQG++ Sbjct: 23 LTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQI--SELAPDAFQGLR 80 Query: 202 KLSYIRIADTNITTIPQGL---PPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSI 258 L+ + + IT +P+ L SL L L+ NKI + + + L+NL L L N + Sbjct: 81 SLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKL 140 Query: 259 SAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGS 310 + G+ + ++ +HL N + H YLH N I G+ Sbjct: 141 QTIAKGTFSPLRAIQTMHLAQNPFI-----CDCHLKWLADYLHTNPIETSGA 187 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 18/49 (36%), Positives = 33/49 (67%) Query: 92 NKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKN 140 NKI ++ F++L NL+ L L +NK+ I+ G F+PL ++ ++L++N Sbjct: 114 NKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN 162 >3CIG-A nrPDB Length = 697 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 73/303 (24%), Positives = 120/303 (39%), Gaps = 63/303 (20%) Query: 58 RCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNK 117 +C V CS L L +P DLP + +L+L +N++ + +F L L N Sbjct: 1 QCTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNS 60 Query: 118 ISKISPGAFAPLVKLERLYLSKNQLKELPEK---MPKTLQELRVHENEITKVRKSVFNGL 174 ISK+ P L L+ L L N+L ++ ++ L EL + N I K++ + F Sbjct: 61 ISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQ 120 Query: 175 NQMIVVELGTNPLKSSGIENGA------------------------FQGMKKLSYIRIAD 210 +I ++L N L S+ + G F G L + ++ Sbjct: 121 KNLIKLDLSHNGLSSTKLGTGVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSS 180 Query: 211 TNITTIPQG-----------------LPPSLTE-------------LHLDGNKITKVDAA 240 + G L P LTE L L N++ + Sbjct: 181 NPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSES 240 Query: 241 SLKGL--NNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVP----GGLADHKY 294 + GL NL +L LS+N++ V NGS + P LR L L N + ++ GL++ +Y Sbjct: 241 TFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRY 300 Query: 295 IQV 297 + + Sbjct: 301 LSL 303 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 61/246 (24%), Positives = 102/246 (41%), Gaps = 21/246 (8%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKN------ 140 LDL N + ++ +G F L +L L L N I ++SP +F L L L L + Sbjct: 253 LDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFTKQSV 312 Query: 141 ------QLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIEN 194 + + + K L+ L + +N I + + F GL + + L + N Sbjct: 313 SLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLSKTFTSLQTLTN 372 Query: 195 GAFQGMKK--LSYIRIADTNITTIPQGLPPSLTELH---LDGNKI-TKVDAASLKGLNNL 248 F + L + + +I+ I G L +L L N+I K+ +GL N+ Sbjct: 373 ETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWRGLRNI 432 Query: 249 AKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKV---PGGLADHKYIQVVYLHNNNI 305 ++ LS+N + S A P L+ L L L V P + + ++ L NNNI Sbjct: 433 FEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNI 492 Query: 306 SAIGSN 311 + I + Sbjct: 493 ANINED 498 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 30/103 (29%), Positives = 48/103 (46%), Gaps = 8/103 (7%) Query: 63 LRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKI- 121 LR V ++ + P + +LDL NN I I + + L+NL L +N ++++ Sbjct: 461 LRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLLEGLENLEILDFQHNNLARLW 520 Query: 122 ---SPGAFAPLVK----LERLYLSKNQLKELPEKMPKTLQELR 157 +PG +K L L L N L E+P + K L EL+ Sbjct: 521 KRANPGGPVNFLKGLSHLHILNLESNGLDEIPVGVFKNLFELK 563 Score = 31.2 bits (69), Expect = 0.81, Method: Compositional matrix adjust. Identities = 37/130 (28%), Positives = 63/130 (48%), Gaps = 14/130 (10%) Query: 56 PFRCQCHLRVVQCSDLGLEKVPKDLPP---DTALLDLQNNKITEI-KDGD-------FKN 104 PFR +L ++ S+ + + +DL + +LD Q+N + + K + K Sbjct: 475 PFRPLRNLTILDLSNNNIANINEDLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKG 534 Query: 105 LKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKM---PKTLQELRVHEN 161 L +LH L L +N + +I G F L +L+ + L N L +L + +L+ L + +N Sbjct: 535 LSHLHILNLESNGLDEIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKN 594 Query: 162 EITKVRKSVF 171 IT V K VF Sbjct: 595 LITSVEKDVF 604 >3ULU-A nrPDB Length = 694 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 75/303 (24%), Positives = 120/303 (39%), Gaps = 63/303 (20%) Query: 58 RCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNK 117 +C V CS L L +VP DLP + +L+L +N++ + +F L +L + N Sbjct: 11 KCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNT 70 Query: 118 ISKISPGAFAPLVKLERLYLSKNQLKELPEK---MPKTLQELRVHENEITKVRKSVFNGL 174 ISK+ P L L+ L L N+L +L +K L EL + N I K++ + F Sbjct: 71 ISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQ 130 Query: 175 NQMIVVELGTNPLKSSGI--------------ENGAFQGMK----------KLSYIRIAD 210 +I ++L N L S+ + N Q +K L + ++ Sbjct: 131 KNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSS 190 Query: 211 TNITTIPQG-----------------LPPSLTE-------------LHLDGNKITKVDAA 240 I G L PSLTE L L ++++ Sbjct: 191 NQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNT 250 Query: 241 SLKGL--NNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPG----GLADHKY 294 + GL NL L LS+N+++ V N S A P L L N + + GL + +Y Sbjct: 251 TFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRY 310 Query: 295 IQV 297 + + Sbjct: 311 LNL 313 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 49/214 (22%), Positives = 89/214 (41%), Gaps = 32/214 (14%) Query: 85 ALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKN---- 140 +LDL N + + + F L L L N I + + L + L L ++ Sbjct: 261 TMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQ 320 Query: 141 --QLKELPE------KMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGI 192 L LP+ + K L+ L + +N+I ++ ++F GL + + L Sbjct: 321 SISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLS--------- 371 Query: 193 ENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLG 252 +F ++ L TN T + P L L+L NKI+K+++ + L +L L Sbjct: 372 --NSFTSLRTL-------TNETFVSLAHSP-LHILNLTKNKISKIESDAFSWLGHLEVLD 421 Query: 253 LSFNSISAVDNG-SLANTPHLRELHLNNNKLVKV 285 L N I G ++ E++L+ NK +++ Sbjct: 422 LGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQL 455 Score = 36.6 bits (83), Expect = 0.018, Method: Compositional matrix adjust. Identities = 49/214 (22%), Positives = 88/214 (41%), Gaps = 46/214 (21%) Query: 86 LLDLQNNKI-TEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKE 144 +LDL N+I E+ +++ L+N+ + L NK +++ +FA + L+RL L + LK Sbjct: 419 VLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKN 478 Query: 145 LPEKMPKTLQELR------------------------------VHENEITKVRKSV---- 170 + + P Q LR + N + ++ K Sbjct: 479 V-DSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGG 537 Query: 171 ----FNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGL---PPS 223 GL+ + ++ L +N +E F+ + +L I + N+ T+P + S Sbjct: 538 PIYFLKGLSHLHILNLESNGFDEIPVE--VFKDLFELKIIDLGLNNLNTLPASVFNNQVS 595 Query: 224 LTELHLDGNKITKVDAASLK-GLNNLAKLGLSFN 256 L L+L N IT V+ NL +L + FN Sbjct: 596 LKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFN 629 Score = 36.2 bits (82), Expect = 0.022, Method: Compositional matrix adjust. Identities = 59/220 (26%), Positives = 96/220 (43%), Gaps = 36/220 (16%) Query: 108 LHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVR 167 LH L L NKISKI AF+ L LE L L N++ QEL E Sbjct: 393 LHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIG----------QELTGQE------- 435 Query: 168 KSVFNGLNQMIVVELGTNPLKSSGIENGAFQ---GMKKLSYIRIADTNITTIPQGLPP-- 222 + GL + + L N K + +F +++L R+A N+ + P P Sbjct: 436 ---WRGLENIFEIYLSYN--KYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLR 490 Query: 223 SLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGS--------LANTPHLRE 274 +LT L L N I ++ L+GL L L L N+++ + + L HL Sbjct: 491 NLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHI 550 Query: 275 LHLNNNKLVKVPGGL-ADHKYIQVVYLHNNNISAIGSNDF 313 L+L +N ++P + D ++++ L NN++ + ++ F Sbjct: 551 LNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVF 590 Score = 31.2 bits (69), Expect = 0.81, Method: Compositional matrix adjust. Identities = 20/85 (23%), Positives = 38/85 (44%), Gaps = 3/85 (3%) Query: 50 PMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDT---ALLDLQNNKITEIKDGDFKNLK 106 P GP+ + HL ++ G +++P ++ D ++DL N + + F N Sbjct: 535 PGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQV 594 Query: 107 NLHTLILINNKISKISPGAFAPLVK 131 +L +L L N I+ + F P + Sbjct: 595 SLKSLNLQKNLITSVEKKVFGPAFR 619 >4R6F-A nrPDB Length = 331 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 65/245 (26%), Positives = 113/245 (46%), Gaps = 27/245 (11%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELP 146 L+L NN++ + G F+ L NL TL L NN+++ + G F L L L LS N + + Sbjct: 90 LNLSNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNNNIANIN 149 Query: 147 EKMPK---TLQELRVHENEITKVRKSV--------FNGLNQMIVVELGTNPLKSSGIENG 195 ++M + L L + N + ++ K GL + + L +N I Sbjct: 150 DQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDE--IPRE 207 Query: 196 AFQGMKKLSYIRIADTNITTIP----QGLPPSLTELHLDGNKITKVDAAS--------LK 243 F+ + L+ + +++ NI I +GL +LT L+L N + ++ + LK Sbjct: 208 VFKDLTSLTTLNLSNNNIANINDQMLEGL-TNLTTLNLSHNNLARLWKHANPGGPIYFLK 266 Query: 244 GLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADH-KYIQVVYLHN 302 GL NL L LS N + + L L+L+NN+L +P G+ + ++ + L N Sbjct: 267 GLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNQLTSLPQGVFERLTNLKTLNLSN 326 Query: 303 NNISA 307 N + + Sbjct: 327 NQLQS 331 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 56/192 (29%), Positives = 88/192 (45%), Gaps = 14/192 (7%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 P+ L L NK+ +I K L NL L L NN++ + G F L L L LS NQ Sbjct: 63 PNVRYLALGGNKLHDI--SALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQ 120 Query: 142 LKELPEKMPK---TLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPL------KSSGI 192 L LP+ + + +L L + N I + + GL + + L N L + G Sbjct: 121 LTSLPQGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGG 180 Query: 193 ENGAFQGMKKLSYIRIADTNITTIPQGL---PPSLTELHLDGNKITKVDAASLKGLNNLA 249 +G+ L+ + ++ IP+ + SLT L+L N I ++ L+GL NL Sbjct: 181 PIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQMLEGLTNLT 240 Query: 250 KLGLSFNSISAV 261 L LS N+++ + Sbjct: 241 TLNLSHNNLARL 252 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 46/154 (29%), Positives = 77/154 (50%), Gaps = 14/154 (9%) Query: 50 PMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPD-TAL--LDLQNNKITEIKDGDFKNLK 106 P GP+ + +L + S G +++P+++ D T+L L+L NN I I D + L Sbjct: 178 PGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQMLEGLT 237 Query: 107 NLHTLILINNKISKI----SPGA----FAPLVKLERLYLSKNQLKELPEKMPK---TLQE 155 NL TL L +N ++++ +PG L L L LS N E+P ++ K +L Sbjct: 238 NLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTT 297 Query: 156 LRVHENEITKVRKSVFNGLNQMIVVELGTNPLKS 189 L + N++T + + VF L + + L N L+S Sbjct: 298 LNLSNNQLTSLPQGVFERLTNLKTLNLSNNQLQS 331 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 31/88 (35%), Positives = 48/88 (54%), Gaps = 3/88 (3%) Query: 222 PSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNK 281 P++ L L GNK+ D ++LK L NL L LS N + + G +L L+L+NN+ Sbjct: 63 PNVRYLALGGNKLH--DISALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQ 120 Query: 282 LVKVPGGLADH-KYIQVVYLHNNNISAI 308 L +P G+ + + + L NNNI+ I Sbjct: 121 LTSLPQGVFERLASLTTLNLSNNNIANI 148 >5Y31-B nrPDB Length = 544 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 42/144 (29%), Positives = 64/144 (44%), Gaps = 5/144 (3%) Query: 47 EIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLK 106 E P P CP C C C + +P+ +PPD L + TEI +G F Sbjct: 14 EAYPAKPKCPAVCTCTKDNALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTP 71 Query: 107 NLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPE---KMPKTLQELRVHENEI 163 +L L+ +N IS AF L LE L++ N +K + + K+L L + N + Sbjct: 72 SLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL 131 Query: 164 TKVRKSVFNGLNQMIVVELGTNPL 187 + K +F GL+ + V+L N Sbjct: 132 QTLPKDIFKGLDSLTNVDLRGNSF 155 Score = 35.4 bits (80), Expect = 0.044, Method: Compositional matrix adjust. Identities = 18/71 (25%), Positives = 32/71 (45%) Query: 212 NITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH 271 N +IP+ +PP + L + T++ S +L L + NS + + + PH Sbjct: 37 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPH 96 Query: 272 LRELHLNNNKL 282 L L + NN + Sbjct: 97 LEYLFIENNNI 107 Score = 30.8 bits (68), Expect = 0.85, Method: Compositional matrix adjust. Identities = 23/87 (26%), Positives = 36/87 (41%) Query: 203 LSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVD 262 LS++R T I+ PSL L N + + GL +L L + N+I ++ Sbjct: 52 LSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSIS 111 Query: 263 NGSLANTPHLRELHLNNNKLVKVPGGL 289 + L L L NN L +P + Sbjct: 112 RHTFRGLKSLIHLSLANNNLQTLPKDI 138 >5Y3K-A nrPDB Length = 802 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 65/226 (28%), Positives = 98/226 (43%), Gaps = 24/226 (10%) Query: 53 PVCPFRCQCHLRVVQCSDLGLEKVP---KDLPPDTAL-LDLQNNKITEIKDGDFKNLKNL 108 P P Q H +V C+ L L+ VP P D L L +N+I + D DF L NL Sbjct: 10 PFLPCELQPH-GLVNCNWLFLKSVPHFSAAAPRDNVTSLSLLSNRIHHLHDSDFAQLSNL 68 Query: 109 HTLILINN----KIS--------KISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQEL 156 L L N +S I P F + LE L LS N + +P +P +L L Sbjct: 69 QKLNLKWNCPPAGLSPMHFPCHMTIEPNTFLAVPTLEELNLSYNGITTVP-ALPSSLVSL 127 Query: 157 RVHENEITKVRKSVFNGLNQMIVVELGTNPL------KSSGIENGAFQGMKKLSYIRIAD 210 + I ++ + GL+ + + + N ++ + GA G+ L+++ + Sbjct: 128 ILSRTNILQLDPTSLTGLHALRFLYMDGNCYYKNPCGRALEVAPGALLGLGNLTHLSLKY 187 Query: 211 TNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFN 256 N+TT+P+ LPPSL L L N I + L L L L + N Sbjct: 188 NNLTTVPRSLPPSLEYLLLSYNHIVTLAPEDLANLTALRVLDVGGN 233 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 66/252 (26%), Positives = 112/252 (44%), Gaps = 32/252 (12%) Query: 87 LDLQNNKITEIKDGD-FKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ---- 141 L L +N I++ +G F L +L L L +NK+ +F L +LE L LS N Sbjct: 480 LRLSHNSISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYNSQPFS 539 Query: 142 ----------LKELPEKMPKTLQELRVHENEI-TKVRKSVFNGLNQMIVVELGTNPLKSS 190 + +LP TL+ L + N I ++V + + + + ++ N L Sbjct: 540 MRGVGHNLSFVAQLP-----TLRYLSLAHNGIHSRVSQQLCS--TSLWALDFSGNSLSQM 592 Query: 191 GIENGA----FQGMKKLSYIRIADTNITTI----PQGLPPSLTELHLDGNKITKVDAASL 242 E FQG++ L + ++ + T+ LP SL L L N + + +SL Sbjct: 593 WAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQLLRLRNNYLAFFNWSSL 652 Query: 243 KGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLV-KVPGGLADHKYIQVVYLH 301 L NL L L+ N + A+ NGSL + L+ L ++ N ++ VPG A ++ + L Sbjct: 653 TLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDVSRNSIIFVVPGFFALATRLRELNLS 712 Query: 302 NNNISAIGSNDF 313 N + + + F Sbjct: 713 ANALRTVEPSWF 724 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 57/232 (24%), Positives = 94/232 (40%), Gaps = 37/232 (15%) Query: 73 LEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKL 132 L VP+ LPP L L N I + D NL L L + N Sbjct: 190 LTTVPRSLPPSLEYLLLSYNHIVTLAPEDLANLTALRVLDVGGN---------------C 234 Query: 133 ERLYLSKNQLKELPEKMPK----------TLQELRVHENEITKVRKSVFNGLNQMIVVEL 182 R ++N E P K P+ L+ L + ++ + ++ F GL + V++L Sbjct: 235 RRCDHARNPCVECPHKFPQLHSDTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDL 294 Query: 183 GTNPLKSSGIENGAFQGMKKLSYI--------RIADTNITTIPQ-GLPPSLTELHLDGNK 233 N L + AFQG+ +L + +++ ++T P G SL EL + G Sbjct: 295 SENFLYDCITKTKAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQELDMHGIF 354 Query: 234 ITKVDAASLKGLNN---LAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKL 282 + +L+ L L +L L N I+ G + P LR + L++N++ Sbjct: 355 FRSLSQKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNRI 406 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 69/267 (25%), Positives = 104/267 (38%), Gaps = 71/267 (26%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGA-FAPLVKLERLYLSKNQL--- 142 LDL N + ++ F L L L L +N IS+ G+ F PL L+ L LS N+L Sbjct: 456 LDLSRNNLVTVQPEMFAQLSRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSHNKLDLY 515 Query: 143 -----KELPE--------------------------KMPKTLQELRVHENEI-TKVRKSV 170 ELP ++P TL+ L + N I ++V + + Sbjct: 516 HGRSFTELPRLEALDLSYNSQPFSMRGVGHNLSFVAQLP-TLRYLSLAHNGIHSRVSQQL 574 Query: 171 FNGLNQMIVVELGTNPLKSSGIENGA----FQGMKKLSYIRIADTNITTIP----QGLPP 222 + + ++ N L E FQG++ L + ++ + T+ LP Sbjct: 575 CS--TSLWALDFSGNSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPK 632 Query: 223 SLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSL---------------- 266 SL L L N + + +SL L NL L L+ N + A+ NGSL Sbjct: 633 SLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDVSRNSI 692 Query: 267 --------ANTPHLRELHLNNNKLVKV 285 A LREL+L+ N L V Sbjct: 693 IFVVPGFFALATRLRELNLSANALRTV 719 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 4/116 (3%) Query: 79 DLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLS 138 +LP LL L+NN + L NL TL L N++ +S G+ +L+RL +S Sbjct: 629 NLPKSLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDVS 688 Query: 139 KNQLKELPE---KMPKTLQELRVHENEITKVRKSVFNGL-NQMIVVELGTNPLKSS 190 +N + + + L+EL + N + V S F L + V+++ NPL + Sbjct: 689 RNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDVSANPLHCA 744 Score = 36.2 bits (82), Expect = 0.022, Method: Compositional matrix adjust. Identities = 59/227 (25%), Positives = 89/227 (39%), Gaps = 33/227 (14%) Query: 85 ALLDLQNNKITEI--KDGDFKNLKNLHTLILINNKISKISPG------AFAPLVKLERLY 136 +LDL N + + K F+ L L L L N K+S +F L+ L+ L Sbjct: 290 TVLDLSENFLYDCITKTKAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQELD 349 Query: 137 LSKNQLKELPEKMPK------TLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSS 190 + + L +K + LQ L + N I + + +F + ++L N + S Sbjct: 350 MHGIFFRSLSQKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNRI-SG 408 Query: 191 GIE----NGAFQGMKKLSYIRIADTNITTIPQGLPPSLT----------ELHLDGNKITK 236 +E G G KK + + ++T P P S L L N + Sbjct: 409 AVEPVATTGEVDGGKK---VWLTSRDLTPGPLDTPSSEDFMPSCKNLSFTLDLSRNNLVT 465 Query: 237 VDAASLKGLNNLAKLGLSFNSISAVDNGS-LANTPHLRELHLNNNKL 282 V L+ L L LS NSIS NGS L+ L L++NKL Sbjct: 466 VQPEMFAQLSRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSHNKL 512 >2Z80-A nrPDB Length = 353 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 56/187 (29%), Positives = 81/187 (43%), Gaps = 28/187 (14%) Query: 72 GLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVK 131 L +P L LDL NN+IT I + D + NL L+L +N I+ I +F+ L Sbjct: 42 SLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGS 101 Query: 132 LERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSG 191 LE L LS N L L S F L+ + + L NP K+ G Sbjct: 102 LEHLDLSYNYLSNLS---------------------SSWFKPLSSLTFLNLLGNPYKTLG 140 Query: 192 IENGAFQGMKKLSYIRIADTNITTIPQ-----GLPPSLTELHLDGNKITKVDAASLKGLN 246 E F + KL +R+ + + T Q GL L EL +D + + + SLK + Sbjct: 141 -ETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTF-LEELEIDASDLQSYEPKSLKSIQ 198 Query: 247 NLAKLGL 253 N++ L L Sbjct: 199 NVSHLIL 205 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 22/71 (30%), Positives = 38/71 (53%) Query: 212 NITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH 271 ++ +IP GL ++ L L N+IT + + L+ NL L L+ N I+ ++ S ++ Sbjct: 42 SLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGS 101 Query: 272 LRELHLNNNKL 282 L L L+ N L Sbjct: 102 LEHLDLSYNYL 112 >2Z7X-A nrPDB Length = 549 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 56/187 (29%), Positives = 81/187 (43%), Gaps = 28/187 (14%) Query: 72 GLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVK 131 L +P L LDL NN+IT I + D + NL L+L +N I+ I +F+ L Sbjct: 16 SLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGS 75 Query: 132 LERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSG 191 LE L LS N L L S F L+ + + L NP K+ G Sbjct: 76 LEHLDLSYNYLSNLS---------------------SSWFKPLSSLTFLNLLGNPYKTLG 114 Query: 192 IENGAFQGMKKLSYIRIADTNITTIPQ-----GLPPSLTELHLDGNKITKVDAASLKGLN 246 E F + KL +R+ + + T Q GL L EL +D + + + SLK + Sbjct: 115 -ETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGL-TFLEELEIDASDLQSYEPKSLKSIQ 172 Query: 247 NLAKLGL 253 N++ L L Sbjct: 173 NVSHLIL 179 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 22/71 (30%), Positives = 38/71 (53%) Query: 212 NITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH 271 ++ +IP GL ++ L L N+IT + + L+ NL L L+ N I+ ++ S ++ Sbjct: 16 SLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGS 75 Query: 272 LRELHLNNNKL 282 L L L+ N L Sbjct: 76 LEHLDLSYNYL 86 >6HLU-A nrPDB Length = 974 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/177 (33%), Positives = 92/177 (51%), Gaps = 14/177 (7%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKEL- 145 L L +N+IT+I +LK+L L L +N+IS I+P L L L LS+NQ+ ++ Sbjct: 206 LSLSSNQITDI--APLASLKSLTELSLSSNQISDIAP--LESLKSLTELQLSRNQISDIA 261 Query: 146 PEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSY 205 P + K+L EL++ N+IT + + L + ++L N + + + + LS Sbjct: 262 PLESLKSLTELQLSSNQITDI--APLASLKSLTELQLSRNQIS----DIAPLESLNSLSK 315 Query: 206 IRIADTNITTI-PQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAV 261 + + IT I P SLTEL L N+IT D A L L +L+ L LS N IS + Sbjct: 316 LWLNGNQITDIAPLASLNSLTELELSSNQIT--DIAPLASLKSLSTLWLSSNQISDI 370 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 100/218 (45%), Gaps = 37/218 (16%) Query: 116 NKISKISPGAFAPLVKLERLYLSKNQLKEL-----------------------PEKMPKT 152 N+I+ ISP A L L L+L +NQ+ ++ P + K+ Sbjct: 101 NQITDISP--LASLNSLSMLWLDRNQITDIAPLASLNSLSMLWLFGNKISDIAPLESLKS 158 Query: 153 LQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTN 212 L EL++ N+IT + + L + + L N + + + +K L+ + ++ Sbjct: 159 LTELQLSSNQITDI--APLASLKSLTELSLSGNNIS----DIAPLESLKSLTELSLSSNQ 212 Query: 213 ITTI-PQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH 271 IT I P SLTEL L N+I+ D A L+ L +L +L LS N IS D L + Sbjct: 213 ITDIAPLASLKSLTELSLSSNQIS--DIAPLESLKSLTELQLSRNQIS--DIAPLESLKS 268 Query: 272 LRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIG 309 L EL L++N++ + LA K + + L N IS I Sbjct: 269 LTELQLSSNQITDI-APLASLKSLTELQLSRNQISDIA 305 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 66/236 (27%), Positives = 111/236 (47%), Gaps = 27/236 (11%) Query: 34 SGIGPEEHFPEVPE-------IEPMGPVCPFRCQCHLRVV--QCSDLGLEKVPKDLPPDT 84 S I P E + E I + P+ + L + Q SD+ + K L Sbjct: 192 SDIAPLESLKSLTELSLSSNQITDIAPLASLKSLTELSLSSNQISDIAPLESLKSLTE-- 249 Query: 85 ALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKE 144 L L N+I++I ++LK+L L L +N+I+ I+P A L L L LS+NQ+ + Sbjct: 250 --LQLSRNQISDI--APLESLKSLTELQLSSNQITDIAP--LASLKSLTELQLSRNQISD 303 Query: 145 L-PEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKL 203 + P + +L +L ++ N+IT + + LN + +EL +N + + +K L Sbjct: 304 IAPLESLNSLSKLWLNGNQITDI--APLASLNSLTELELSSNQIT----DIAPLASLKSL 357 Query: 204 SYIRIADTNITTI-PQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSI 258 S + ++ I+ I P SL+EL L N+I+ D + L LN+L + N I Sbjct: 358 STLWLSSNQISDIAPLASLESLSELSLSSNQIS--DISPLASLNSLTGFDVRRNPI 411 Score = 32.3 bits (72), Expect = 0.33, Method: Compositional matrix adjust. Identities = 49/187 (26%), Positives = 78/187 (41%), Gaps = 51/187 (27%) Query: 12 QVSWAGPFQQ-KGLFDFML-EDEASGIGPEEHFPEVPE-------IEPMGPVCPFRCQCH 62 Q+S P + K L + L ++ S I P E + E I + P+ + Sbjct: 234 QISDIAPLESLKSLTELQLSRNQISDIAPLESLKSLTELQLSSNQITDIAPLASLKSLTE 293 Query: 63 LRVV--QCSDLG----LEKVPK---------DLPPDTAL-----LDLQNNKITEIKDGDF 102 L++ Q SD+ L + K D+ P +L L+L +N+IT+I Sbjct: 294 LQLSRNQISDIAPLESLNSLSKLWLNGNQITDIAPLASLNSLTELELSSNQITDI--APL 351 Query: 103 KNLKNLHTLILINNKISKISPGA-----------------FAPLVKLERLY---LSKNQL 142 +LK+L TL L +N+IS I+P A +PL L L + +N + Sbjct: 352 ASLKSLSTLWLSSNQISDIAPLASLESLSELSLSSNQISDISPLASLNSLTGFDVRRNPI 411 Query: 143 KELPEKM 149 K LPE + Sbjct: 412 KRLPETI 418 >3WPI-A nrPDB Length = 803 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 26/221 (11%) Query: 61 CHLR---VVQCSDLGLEKVPKDLPP----DTALLDLQNNKITEIKDGDFKNLKNLHTLIL 113 C L+ +V C+ L L+ VP+ + L L +N+I + + DF +L NL L L Sbjct: 14 CELKPHGLVDCNWLFLKSVPRFSAAASCSNITRLSLISNRIHHLHNSDFVHLSNLRQLNL 73 Query: 114 INN----KIS--------KISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHEN 161 N +S I P F + LE L LS N + +P ++P +L L + Sbjct: 74 KWNCPPTGLSPLHFSCHMTIEPRTFLAMRTLEELNLSYNGITTVP-RLPSSLVNLSLSHT 132 Query: 162 EITKVRKSVFNGLNQMIVVELG-----TNPLKSS-GIENGAFQGMKKLSYIRIADTNITT 215 I + + GL + V+ + NP + + GA G+ +L+++ + N+T Sbjct: 133 NILVLDANSLAGLYSLRVLFMDGNCYYKNPCTGAVKVTPGALLGLSQLTHLSLKYNNLTK 192 Query: 216 IPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFN 256 +P+ LPPSL L + N I K+ L L +L L + N Sbjct: 193 VPRQLPPSLEYLLVSYNLIVKLGPEDLAQLTSLRVLDVGGN 233 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 61/241 (25%), Positives = 101/241 (41%), Gaps = 28/241 (11%) Query: 73 LEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKL 132 L KVP+ LPP L + N I ++ D L +L L + N + A P ++ Sbjct: 190 LTKVPRQLPPSLEYLLVSYNLIVKLGPEDLAQLTSLRVLDVGGN--CRRCDHAPNPCIEC 247 Query: 133 --ERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSS 190 + L+L L L+ L + ++ + + S F GL Q+ V++L N L S Sbjct: 248 GQKSLHLHPETFHHLSH-----LEGLVLKDSSLHTLNSSWFQGLVQLSVLDLSENFLYES 302 Query: 191 GIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAK 250 AFQ + +L + ++ + S LHL A+S K L +L + Sbjct: 303 ITHTNAFQNLTRLRKLNLSFNYRKKV------SFARLHL---------ASSFKNLVSLQE 347 Query: 251 L---GLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGL-ADHKYIQVVYLHNNNIS 306 L G+ F ++ LA+ P L LHL N + + + + ++ V L +N IS Sbjct: 348 LNMNGIFFRLLNKYTLRWLADLPKLHTLHLQMNFINQAQLSIFGTFRALRFVDLSDNRIS 407 Query: 307 A 307 Sbjct: 408 G 408 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/180 (30%), Positives = 75/180 (41%), Gaps = 23/180 (12%) Query: 153 LQELRVHENEITKVRKSVFNGLNQMIVVEL-------GTNPLKSS---GIENGAFQGMKK 202 + L + N I + S F L+ + + L G +PL S IE F M+ Sbjct: 44 ITRLSLISNRIHHLHNSDFVHLSNLRQLNLKWNCPPTGLSPLHFSCHMTIEPRTFLAMRT 103 Query: 203 LSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISA-- 260 L + ++ ITT+P+ LP SL L L I +DA SL GL +L L + N Sbjct: 104 LEELNLSYNGITTVPR-LPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNCYYKNP 162 Query: 261 ------VDNGSLANTPHLRELHLNNNKLVKVPGGL-ADHKYIQVVYLHNNNISAIGSNDF 313 V G+L L L L N L KVP L +Y+ V Y N I +G D Sbjct: 163 CTGAVKVTPGALLGLSQLTHLSLKYNNLTKVPRQLPPSLEYLLVSY---NLIVKLGPEDL 219 Score = 31.6 bits (70), Expect = 0.53, Method: Compositional matrix adjust. Identities = 57/226 (25%), Positives = 88/226 (38%), Gaps = 30/226 (13%) Query: 85 ALLDLQNNKITE--IKDGDFKNLKNLHTLILINNKISKIS------PGAFAPLVKLERL- 135 ++LDL N + E F+NL L L L N K+S +F LV L+ L Sbjct: 290 SVLDLSENFLYESITHTNAFQNLTRLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQELN 349 Query: 136 -------YLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLK 188 L+K L+ L + +PK L L + N I + + S+F + V+L N + Sbjct: 350 MNGIFFRLLNKYTLRWLAD-LPK-LHTLHLQMNFINQAQLSIFGTFRALRFVDLSDNRIS 407 Query: 189 S-SGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLT----------ELHLDGNKITKV 237 S + + + + P P S + L N + + Sbjct: 408 GPSTLSEATPEEADDAEQEELLSADPHPAPLSTPASKNFMDRCKNFKFTMDLSRNNLVTI 467 Query: 238 DAASLKGLNNLAKLGLSFNSISAVDNGS-LANTPHLRELHLNNNKL 282 L+ L L LS NSI+ NGS +L+ L L++NKL Sbjct: 468 KPEMFVQLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKL 513 Score = 31.2 bits (69), Expect = 0.78, Method: Compositional matrix adjust. Identities = 66/265 (24%), Positives = 99/265 (37%), Gaps = 67/265 (25%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGA-FAPLVKLERLYLSKNQL--- 142 +DL N + IK F L L L L +N I++ G+ F PL L+ L LS N+L Sbjct: 457 MDLSRNNLVTIKPEMFVQLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLY 516 Query: 143 -----KELPEKMP-------------------------KTLQELRVHENEITKVRKSVFN 172 ELP+ LQ L + N+I S N Sbjct: 517 HWKSFSELPQLQALDLSYNSQPFSMKGIGHQFSFVTHLSMLQSLSLAHNDIHTRVSSHLN 576 Query: 173 GLNQMIVVELGTNPLKSSGIENGA----FQGMKKLSYIRIADTNITTI-PQGLP------ 221 N + ++ N + E G FQG+ L + ++ N+ + PQ L Sbjct: 577 S-NSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKSL 635 Query: 222 ---------------------PSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISA 260 P+L L L GN++ + +L L KL +S NSI + Sbjct: 636 KLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTQGTLPNGTLLQKLDVSSNSIVS 695 Query: 261 VDNGSLANTPHLRELHLNNNKLVKV 285 V A L+E++L++N L V Sbjct: 696 VVPAFFALAVELKEVNLSHNILKTV 720 >3J0A-A nrPDB Length = 844 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 76/282 (26%), Positives = 122/282 (43%), Gaps = 73/282 (25%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELP 146 LDL + + + F+ LK+L L L NKI+KI+ AF L L+ L LS N L EL Sbjct: 271 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGEL- 329 Query: 147 EKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYI 206 S F GL ++ ++L N + + I++ F+ ++KL + Sbjct: 330 --------------------YSSNFYGLPKVAYIDLQKNHI--AIIQDQTFKFLEKLQTL 367 Query: 207 RIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDN-GS 265 + D +TTI PS+ ++ L GNK+ + +L NL + LS N + +D Sbjct: 368 DLRDNALTTI--HFIPSIPDIFLSGNKLVTLPKINLTA--NL--IHLSENRLENLDILYF 421 Query: 266 LANTPHLRELHLNNNKLVKVPG----------------------------------GLAD 291 L PHL+ L LN N+ G GL+ Sbjct: 422 LLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLS- 480 Query: 292 HKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSN 333 ++QV+YL++N ++++ PPG + + G+SL SN Sbjct: 481 --HLQVLYLNHNYLNSL------PPGVFSHLTALRGLSLNSN 514 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 75/287 (26%), Positives = 122/287 (42%), Gaps = 59/287 (20%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 P A +DLQ N I I+D FK L+ L TL L +N ++ I F P + ++LS N+ Sbjct: 338 PKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIH---FIP--SIPDIFLSGNK 392 Query: 142 LKELP----------------EKMPKTLQELRVHENEITKVRKSVFN------------G 173 L LP E + LRV +I + ++ F+ Sbjct: 393 LVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPS 452 Query: 174 LNQMIVVELGTNPLK---SSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELH-- 228 L Q+ LG N L+ + + F+G+ L + + + ++P G+ LT L Sbjct: 453 LEQLF---LGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGL 509 Query: 229 -LDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPG 287 L+ N++T + L NL L +S N + A + + L L + +NK + Sbjct: 510 SLNSNRLTVLSHNDLPA--NLEILDISRNQLLAPNPDVFVS---LSVLDITHNKFI-CEC 563 Query: 288 GLADHKYIQVVYLHNNNISAIGSNDFCPPG--YNTKKASYSGVSLFS 332 L+ + +L++ N++ G PP Y S+SGVSLFS Sbjct: 564 ELSTF----INWLNHTNVTIAG-----PPADIYCVYPDSFSGVSLFS 601 Score = 32.3 bits (72), Expect = 0.35, Method: Compositional matrix adjust. Identities = 60/249 (24%), Positives = 101/249 (40%), Gaps = 36/249 (14%) Query: 97 IKDGDFKNLKNLHTLILINNKISKISPG-AFAPLVKLERLYLSKNQL-----KELPEKMP 150 +KDG F+NLK L L L N+I + +F L L+ + S NQ+ EL Sbjct: 114 LKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQG 173 Query: 151 KTLQELRVHENEITKVRKSV-----FNGLNQMI--VVELGTN--PLKSSGIENGAFQGMK 201 KTL + N + R SV N M+ ++++ N + +G + A + Sbjct: 174 KTLSFFSLAANSLYS-RVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQ 232 Query: 202 KLSYI-------------RIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNL 248 S I I D + T S+ L L + +++ + L +L Sbjct: 233 AFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDL 292 Query: 249 AKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPG----GLADHKYIQVVYLHNNN 304 L L++N I+ + + + +L+ L+L+ N L ++ GL YI L N+ Sbjct: 293 KVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYID---LQKNH 349 Query: 305 ISAIGSNDF 313 I+ I F Sbjct: 350 IAIIQDQTF 358 >5D3I-A nrPDB Length = 568 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 84/208 (40%), Gaps = 40/208 (19%) Query: 76 VPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERL 135 +P L LDL NKIT I GD + NL LIL +++I+ I AF L LE L Sbjct: 24 IPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHL 83 Query: 136 YLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENG 195 LS N L L S F L+ + + L NP ++ G+ Sbjct: 84 DLSDNHLSSLS---------------------SSWFGPLSSLKYLNLMGNPYQTLGV-TS 121 Query: 196 AFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSF 255 F + L +RI N+ T ++I ++D A L LN L LS Sbjct: 122 LFPNLTNLQTLRIG--NVETF---------------SEIRRIDFAGLTSLNELEIKALSL 164 Query: 256 NSISAVDNGSLANTPHLRELHLNNNKLV 283 + + S+ + HL LHL+ + + Sbjct: 165 RNYQSQSLKSIRDIHHL-TLHLSESAFL 191 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 34/125 (27%), Positives = 53/125 (42%), Gaps = 7/125 (5%) Query: 212 NITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH 271 + T+IP GL ++ L L NKIT + L+ NL L L + I+ ++ + + Sbjct: 20 SFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGS 79 Query: 272 LRELHLNNNKLVKVP----GGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSG 327 L L L++N L + G L+ KY+ L N +G P N + Sbjct: 80 LEHLDLSDNHLSSLSSSWFGPLSSLKYLN---LMGNPYQTLGVTSLFPNLTNLQTLRIGN 136 Query: 328 VSLFS 332 V FS Sbjct: 137 VETFS 141 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 33/133 (24%), Positives = 55/133 (41%), Gaps = 31/133 (23%) Query: 56 PFRCQC--HLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLIL 113 P CQ +R + S G+ V +P +LD+ NN NL + L Sbjct: 407 PDSCQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNN--------------NLDSFSL 452 Query: 114 INNKISKISPGAFAPLVKLERLYLSKNQLKELPE-KMPKTLQELRVHENEITKVRKSVFN 172 F P +L+ LY+S+N+LK LP+ + L +++ EN ++ K Sbjct: 453 ------------FLP--RLQELYISRNKLKTLPDASLFPVLLVMKIRENAVSTFSKDQLG 498 Query: 173 GLNQMIVVELGTN 185 ++ +E G N Sbjct: 499 SFPKLETLEAGDN 511 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 53/220 (24%), Positives = 94/220 (42%), Gaps = 46/220 (20%) Query: 102 FKNLKNLHTL------ILINNKISKISPGAFAPLVK-LERLYLSKNQLKE--LPEKMPK- 151 F +L +++L I + N + P +F+ +K LE L LS+N + E L K Sbjct: 303 FYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKG 362 Query: 152 ---TLQELRVHENEITKVRKS--VFNGLNQMIVVELGTN---PLKSSGIENGAFQGMKKL 203 +LQ L + +N + ++K+ + L + +++ N P+ S Q +K+ Sbjct: 363 AWPSLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPDSC------QWPEKM 416 Query: 204 SYIRIADTNI----TTIPQGLP----------------PSLTELHLDGNKITKVDAASLK 243 ++ ++ T I T IPQ L P L EL++ NK+ + ASL Sbjct: 417 RFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDSFSLFLPRLQELYISRNKLKTLPDASLF 476 Query: 244 GLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLV 283 + L + + N++S L + P L L +N V Sbjct: 477 PV--LLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFV 514 >3A7C-A nrPDB Length = 580 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 84/208 (40%), Gaps = 40/208 (19%) Query: 76 VPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERL 135 +P L LDL NKIT I GD + NL LIL +++I+ I AF L LE L Sbjct: 46 IPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHL 105 Query: 136 YLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENG 195 LS N L L S F L+ + + L NP ++ G+ Sbjct: 106 DLSDNHLSSLSS---------------------SWFGPLSSLKYLNLMGNPYQTLGV-TS 143 Query: 196 AFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSF 255 F + L +RI N+ T ++I ++D A L LN L LS Sbjct: 144 LFPNLTNLQTLRIG--NVETF---------------SEIRRIDFAGLTSLNELEIKALSL 186 Query: 256 NSISAVDNGSLANTPHLRELHLNNNKLV 283 + + S+ + HL LHL+ + + Sbjct: 187 RNYQSQSLKSIRDIHHL-TLHLSESAFL 213 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 34/125 (27%), Positives = 53/125 (42%), Gaps = 7/125 (5%) Query: 212 NITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH 271 + T+IP GL ++ L L NKIT + L+ NL L L + I+ ++ + + Sbjct: 42 SFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGS 101 Query: 272 LRELHLNNNKLVKVP----GGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSG 327 L L L++N L + G L+ KY+ L N +G P N + Sbjct: 102 LEHLDLSDNHLSSLSSSWFGPLSSLKYLN---LMGNPYQTLGVTSLFPNLTNLQTLRIGN 158 Query: 328 VSLFS 332 V FS Sbjct: 159 VETFS 163 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 36/138 (26%), Positives = 59/138 (42%), Gaps = 31/138 (22%) Query: 56 PFRCQC--HLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLIL 113 P CQ +R + S G+ V +P +LD+ NN NL + L Sbjct: 429 PDSCQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNN--------------NLDSFSL 474 Query: 114 INNKISKISPGAFAPLVKLERLYLSKNQLKELPE-KMPKTLQELRVHENEITKVRKSVFN 172 F P +L+ LY+S+N+LK LP+ + L +++ N++ V +F+ Sbjct: 475 ------------FLP--RLQELYISRNKLKTLPDASLFPVLLVMKIASNQLKSVPDGIFD 520 Query: 173 GLNQMIVVELGTNPLKSS 190 L + + L TNP S Sbjct: 521 RLTSLQKIWLHTNPWDCS 538 >3V44-A nrPDB Length = 407 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 64/239 (26%), Positives = 101/239 (42%), Gaps = 43/239 (17%) Query: 102 FKNLKNLHTLILINNKISKISPGA-FAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHE 160 FK L +L L+L +N I KI P + F + + L L+ N++K + E+ L Sbjct: 125 FKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEE-----DLLNFQG 179 Query: 161 NEITKVRKSVFNGLNQMIVVELGT----NPLKSSGIE------NGAFQGMKKLSYIRIAD 210 T +R S L M LG NP K++ I NG + M K + IA Sbjct: 180 KHFTLLRLSSIT-LQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAG 238 Query: 211 TNITTIP------------------------QGLPPS-LTELHLDGNKITKVDAASLKGL 245 T I ++ +GL S + L +KI + + Sbjct: 239 TKIQSLILSNSYNMGSSFGHTNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHF 298 Query: 246 NNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADH-KYIQVVYLHNN 303 +L +L L+ N I+ +D+ + HL+EL L+ N+L VP G+ D +Q ++LH N Sbjct: 299 TDLEQLTLAQNEINKIDDNAFWGLTHLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTN 357 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 27/77 (35%), Positives = 41/77 (53%), Gaps = 3/77 (3%) Query: 88 DLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPE 147 DL +KI + F + +L L L N+I+KI AF L L+ L L NQLK +P+ Sbjct: 281 DLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLTHLKELALDTNQLKSVPD 340 Query: 148 KM---PKTLQELRVHEN 161 + +LQ++ +H N Sbjct: 341 GIFDRLTSLQKIWLHTN 357 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 70/163 (42%), Gaps = 22/163 (13%) Query: 68 CSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFA 127 C + GL +VP +LP +DL N I E+ + F L++L L K+ + +PG Sbjct: 17 CINRGLHQVP-ELPAHVNYVDLSLNSIAELNETSFSRLQDLQFL-----KVEQQTPG--- 67 Query: 128 PLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPL 187 L + N + L +L L++ N+ ++ FNGL + V+ L L Sbjct: 68 -------LVIRNNTFRGLS-----SLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNL 115 Query: 188 KSSGIENGAFQGMKKLSYIRIADTNITTI-PQGLPPSLTELHL 229 + + F+ + L + + D NI I P ++ H+ Sbjct: 116 DGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHV 158 Score = 34.7 bits (78), Expect = 0.073, Method: Compositional matrix adjust. Identities = 19/58 (32%), Positives = 29/58 (50%) Query: 83 DTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKN 140 D L L N+I +I D F L +L L L N++ + G F L L++++L N Sbjct: 300 DLEQLTLAQNEINKIDDNAFWGLTHLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTN 357 >5GY2-A nrPDB Length = 455 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 40/147 (27%), Positives = 70/147 (47%), Gaps = 24/147 (16%) Query: 158 VHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIP 217 + +++I + KSVF+ + + L N + I++ AF G+ L Sbjct: 282 LSKSKIFALLKSVFSHFTDLEQLTLAQNEINK--IDDNAFWGLTHL-------------- 325 Query: 218 QGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHL 277 +L+L N + +D+ + L+ L L LS+N I A+ + S P+L+EL L Sbjct: 326 -------LKLNLSQNFLGSIDSRMFENLDKLEVLDLSYNHIRALGDQSFLGLPNLKELAL 378 Query: 278 NNNKLVKVPGGLADH-KYIQVVYLHNN 303 + N+L VP G+ D +Q ++LH N Sbjct: 379 DTNQLKSVPDGIFDRLTSLQKIWLHTN 405 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 40/124 (32%), Positives = 60/124 (48%), Gaps = 5/124 (4%) Query: 88 DLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPE 147 DL +KI + F + +L L L N+I+KI AF L L +L LS+N L + Sbjct: 281 DLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLTHLLKLNLSQNFLGSIDS 340 Query: 148 KMPKTLQELRVHE---NEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLS 204 +M + L +L V + N I + F GL + + L TN LKS + +G F + L Sbjct: 341 RMFENLDKLEVLDLSYNHIRALGDQSFLGLPNLKELALDTNQLKS--VPDGIFDRLTSLQ 398 Query: 205 YIRI 208 I + Sbjct: 399 KIWL 402 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 37/112 (33%), Positives = 54/112 (48%), Gaps = 5/112 (4%) Query: 83 DTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQL 142 D L L N+I +I D F L +L L L N + I F L KLE L LS N + Sbjct: 300 DLEQLTLAQNEINKIDDNAFWGLTHLLKLNLSQNFLGSIDSRMFENLDKLEVLDLSYNHI 359 Query: 143 KELPEK----MPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSS 190 + L ++ +P L+EL + N++ V +F+ L + + L TNP S Sbjct: 360 RALGDQSFLGLP-NLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTNPWDCS 410 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 70/163 (42%), Gaps = 22/163 (13%) Query: 68 CSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFA 127 C + GL +VP +LP +DL N I E+ + F L++L L K+ + +PG Sbjct: 17 CINRGLHQVP-ELPAHVNYVDLSLNSIAELNETSFSRLQDLQFL-----KVEQQTPG--- 67 Query: 128 PLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPL 187 L + N + L +L L++ N+ ++ FNGL + V+ L L Sbjct: 68 -------LVIRNNTFRGLS-----SLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNL 115 Query: 188 KSSGIENGAFQGMKKLSYIRIADTNITTI-PQGLPPSLTELHL 229 + + F+ + L + + D NI I P ++ H+ Sbjct: 116 DGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHV 158 >4PUF-A nrPDB Length = 637 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 60/238 (25%), Positives = 109/238 (45%), Gaps = 37/238 (15%) Query: 71 LGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLK-NLHTLILINNKISKISPGAFAPL 129 LGL +P +P L L NN++ + + NL+ N+ TL +N+++ I P Sbjct: 60 LGLTTIPAYIPEQITTLILDNNELKSLPE----NLQGNIKTLYANSNQLTSI-PATLPDT 114 Query: 130 VKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKS 189 ++ + LS N++ ELPE++P LQ L + N+I+ + +++ L + V + Sbjct: 115 IQ--EMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYD-------- 164 Query: 190 SGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLA 249 + I +++++ + ++T +P+ LPP L L N +T + ASL L Sbjct: 165 NSIRTLPAHLPSEITHLNVQSNSLTALPETLPPGLKTLEAGENALTSL-PASLPP--ELQ 221 Query: 250 KLGLSFNSISA-------------VDNGSLANTPH-----LRELHLNNNKLVKVPGGL 289 L +S N I+ V +L N P L+ + + N LV++P L Sbjct: 222 VLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPESL 279 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 47/182 (25%), Positives = 85/182 (46%), Gaps = 14/182 (7%) Query: 56 PFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILIN 115 P Q +++ + + L +P LP ++L N+ITE+ + + L +L L + Sbjct: 87 PENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFH 143 Query: 116 NKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLN 175 NKIS + P +L L + N ++ LP +P + L V N +T + +++ GL Sbjct: 144 NKISCL-PENLPE--ELRYLSVYDNSIRTLPAHLPSEITHLNVQSNSLTALPETLPPGLK 200 Query: 176 QMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKIT 235 +E G N L S +L + ++ IT +P+ LPP++T L + N +T Sbjct: 201 ---TLEAGENALTSLPASLPP-----ELQVLDVSKNQITVLPETLPPTITTLDVSRNALT 252 Query: 236 KV 237 + Sbjct: 253 NL 254 Score = 36.2 bits (82), Expect = 0.020, Method: Compositional matrix adjust. Identities = 34/131 (25%), Positives = 67/131 (51%), Gaps = 13/131 (9%) Query: 186 PLKSSGIENGAFQGMKKL-----SYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAA 240 P K + A Q M+ + +R+ +TTIP +P +T L LD N++ + Sbjct: 30 PAKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPAYIPEQITTLILDNNELKSL-PE 88 Query: 241 SLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYL 300 +L+G N+ L + N ++++ +L +T ++E+ L+ N++ ++P L +Q + L Sbjct: 89 NLQG--NIKTLYANSNQLTSIP-ATLPDT--IQEMELSINRITELPERLP--SALQSLDL 141 Query: 301 HNNNISAIGSN 311 +N IS + N Sbjct: 142 FHNKISCLPEN 152 >3B2D-A nrPDB Length = 603 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 70/283 (24%), Positives = 103/283 (36%), Gaps = 57/283 (20%) Query: 64 RVVQCSDLGLEKVPKDLPPDT------------------------ALLDLQNNKITEIKD 99 + C +LGL ++P LP T LDL +I I + Sbjct: 12 KTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHE 71 Query: 100 GDFKNLKNLHTLILINNKI---------------------SKISPGAFAP---LVKLERL 135 F++ L TL+L N + + IS F P L LE L Sbjct: 72 DTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESL 131 Query: 136 YLSKNQLKEL--PEKMP-KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGI 192 YL N + + P+ P + L+ L N I + + L Q I + L N GI Sbjct: 132 YLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGI 191 Query: 193 ENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGN----KITKVDAASLKGLNNL 248 E GAF S N++ I GL S T+ G + +A LKGL + Sbjct: 192 ELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEM 251 Query: 249 A--KLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGL 289 + L L + S + + + L+EL L L +P G+ Sbjct: 252 SVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGM 294 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 64/242 (26%), Positives = 97/242 (40%), Gaps = 31/242 (12%) Query: 75 KVPKDLPP-DTALLDLQNNKITEIKDGDFKNLKNLHTLILI--NNKISKISPGAFAPLVK 131 K PKD P + +LD QNN I I D ++L+ L L N + I GAF + Sbjct: 142 KFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIF 201 Query: 132 LERLYLSKNQLKELPEKMP-KTLQELRV---HENEITKVRKSVFNGLNQMIVVELGTNPL 187 + L + + T Q L + + + + ++ GL +M V L Sbjct: 202 QSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEH 261 Query: 188 KSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNN 247 + S I + FQ +L + + T++ +P G+ KGLN Sbjct: 262 RFSDISSTTFQCFTQLQELDLTATHLKGLPSGM----------------------KGLNL 299 Query: 248 LAKLGLSFNSISAVDNGSLANTPHLRELHLNNN--KLVKVPGGLADHKYIQVVYLHNNNI 305 L KL LS N + S AN P L L++ N KL G L +Q + L +N+I Sbjct: 300 LKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDI 359 Query: 306 SA 307 A Sbjct: 360 EA 361 >5Y3M-A nrPDB Length = 801 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 88/221 (39%), Gaps = 39/221 (17%) Query: 66 VQCSDLGLEKVPKDLP----PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKI 121 V C+ L L+ VP + L L +N+I + D DF +L NL L L N Sbjct: 22 VDCNWLFLKSVPHFSAGAPRANVTSLSLISNRIHHLHDSDFVHLSNLRVLNLKWN----C 77 Query: 122 SPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSV----------- 170 P +P+ R+ + N +P TL+EL + N IT V Sbjct: 78 PPAGLSPMHFPCRMTIEPNTFLAVP-----TLEELNLSYNGITTVPALPSSLVSLSLSHT 132 Query: 171 ---------FNGLNQMIVVELGTNPL------KSSGIENGAFQGMKKLSYIRIADTNITT 215 F GL+ + + + N ++ + GA G+ L+++ + N+T Sbjct: 133 SILVLGPTHFTGLHALRFLYMDGNCYYMNPCPRALEVAPGALLGLGNLTHLSLKYNNLTE 192 Query: 216 IPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFN 256 +P+ LPPSL L L N I + L L L L + N Sbjct: 193 VPRRLPPSLDTLLLSYNHIVTLAPEDLANLTALRVLDVGGN 233 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 59/229 (25%), Positives = 90/229 (39%), Gaps = 40/229 (17%) Query: 86 LLDLQNNKITE--IKDGDFKNLKNLHTLILINNKISKIS------PGAFAPLVKLERLYL 137 +LDL N + + K F +L L L L N K+S +F LV LE+L + Sbjct: 291 VLDLSENFLYDYITKTTIFNDLTQLRRLNLSFNYHKKVSFAHLHLASSFGSLVSLEKLDM 350 Query: 138 SKNQLKELPE-------KMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSS 190 + L ++PK LQ L + N I + + S+F ++ V+L N + + Sbjct: 351 HGIFFRSLTNITLQSLTRLPK-LQSLHLQLNFINQAQLSIFGAFPSLLFVDLSDNRISGA 409 Query: 191 GIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTE----------------LHLDGNKI 234 A + + + +P+GL P + L L N + Sbjct: 410 ATPAAALGEVD-------SRVEVWRLPRGLAPGPLDAVSSKDFMPSCNLNFTLDLSRNNL 462 Query: 235 TKVDAASLKGLNNLAKLGLSFNSISAVDNGS-LANTPHLRELHLNNNKL 282 + L+ L L LS NSIS NGS LR L L++NKL Sbjct: 463 VTIQQEMFTRLSRLQCLRLSHNSISQAVNGSQFVPLTSLRVLDLSHNKL 511 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 81/310 (26%), Positives = 121/310 (39%), Gaps = 71/310 (22%) Query: 78 KDLPPDTAL---LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGA-FAPLVKLE 133 KD P L LDL N + I+ F L L L L +N IS+ G+ F PL L Sbjct: 443 KDFMPSCNLNFTLDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQAVNGSQFVPLTSLR 502 Query: 134 RLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTN--PLKSSG 191 L LS N+L ++ R F L Q+ ++L N P G Sbjct: 503 VLDLSHNKL-------------------DLYHGRS--FTELPQLEALDLSYNSQPFSMQG 541 Query: 192 I-ENGAFQG-MKKLSYIRIADTNI-TTIPQGLP-PSLTELHLDGNKITKVDAAS------ 241 + N +F + L Y+ +A I + + Q L SL L GN ++++ A Sbjct: 542 VGHNLSFVAQLPSLRYLSLAHNGIHSRVSQKLSSASLRALDFSGNSLSQMWAEGDLYLCF 601 Query: 242 LKGLNNLAKLGLSFNSISAV------------------DN-------GSLANTPHLRELH 276 KGL NL +L LS N + + DN SL P L L Sbjct: 602 FKGLRNLVQLDLSENHLHTLLPRHLDNLPKSLRQLRLRDNNLAFFNWSSLTVLPRLEALD 661 Query: 277 LNNNKLVKVP-GGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPV 335 L N+L + G L +Q + + +N+I F PG+ + ++L +N + Sbjct: 662 LAGNQLKALSNGSLPPGIRLQKLDVSSNSIG------FVIPGFFVRATRLIELNLSANAL 715 Query: 336 QYWEIQPSTF 345 + + PS F Sbjct: 716 K--TVDPSWF 723 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 84/214 (39%), Gaps = 54/214 (25%) Query: 120 KISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIV 179 +++PGA L L L L N L E+P ++P +L L + N I + L + V Sbjct: 168 EVAPGALLGLGNLTHLSLKYNNLTEVPRRLPPSLDTLLLSYNHIVTLAPEDLANLTALRV 227 Query: 180 VELGTNP-----------------------------------LKSSG---IENGAFQGMK 201 +++G N LK S +E F+G+ Sbjct: 228 LDVGGNCRRCDHARNPCRECPKNFPKLHPDTFSHLSRLEGLVLKDSSLYKLEKDWFRGLG 287 Query: 202 KLSYIRIADTNI------TTIPQGLPPSLTELHLDGNKITKVD------AASLKGLNNLA 249 +L + +++ + TTI L L L+L N KV A+S L +L Sbjct: 288 RLQVLDLSENFLYDYITKTTIFNDL-TQLRRLNLSFNYHKKVSFAHLHLASSFGSLVSLE 346 Query: 250 KL---GLSFNSISAVDNGSLANTPHLRELHLNNN 280 KL G+ F S++ + SL P L+ LHL N Sbjct: 347 KLDMHGIFFRSLTNITLQSLTRLPKLQSLHLQLN 380 Score = 28.9 bits (63), Expect = 3.9, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 83/210 (39%), Gaps = 27/210 (12%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 P L LQ N I + + F +L + L +N+IS GA P L + S+ + Sbjct: 370 PKLQSLHLQLNFINQAQLSIFGAFPSLLFVDLSDNRIS----GAATPAAALGEVD-SRVE 424 Query: 142 LKELPEKM-PKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGM 200 + LP + P L + K N ++L N L + I+ F + Sbjct: 425 VWRLPRGLAPGPLDAVS---------SKDFMPSCNLNFTLDLSRNNLVT--IQQEMFTRL 473 Query: 201 KKLSYIRIADTNITTIPQG---LP-PSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFN 256 +L +R++ +I+ G +P SL L L NK+ S L L L LS+N Sbjct: 474 SRLQCLRLSHNSISQAVNGSQFVPLTSLRVLDLSHNKLDLYHGRSFTELPQLEALDLSYN 533 Query: 257 SISAVDNGS------LANTPHLRELHLNNN 280 S G +A P LR L L +N Sbjct: 534 SQPFSMQGVGHNLSFVAQLPSLRYLSLAHN 563 >3RG1-A nrPDB Length = 612 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 51/190 (26%), Positives = 85/190 (44%), Gaps = 16/190 (8%) Query: 64 RVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISP 123 R C +LGL ++P LP T +L+ N + I++ F L NL L L +I+ + Sbjct: 14 RTYNCENLGLREIPDTLPNTTEVLEFSFNFLPTIQNTTFSRLINLIFLDLTRCQINWVHE 73 Query: 124 GAFAPLVKLERLYLSKNQLKELPEKM---PKTLQELRVHENEITKVRKSVFNGLNQMIVV 180 F +L + L+ N L + E PK L+ L + + I+ + + L + + Sbjct: 74 DTFQSHHQLNTIVLTGNPLIFMAETSLTGPKFLKHLFLTQTGISNLEFIPVHNLENLESL 133 Query: 181 ELGTNPLKSSGI-ENGAFQGMKKLS-------YIRIADTNITTIPQGLPPSLTELHLDGN 232 LG+N + S + EN Q +K L YI DTN ++ Q S L+ +GN Sbjct: 134 HLGSNHISSINLPENFPTQNLKVLDFQNNAIHYISRKDTN--SLEQATNLS---LNFNGN 188 Query: 233 KITKVDAASL 242 I ++ + Sbjct: 189 DIKGIEPGAF 198 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 68/281 (24%), Positives = 112/281 (39%), Gaps = 45/281 (16%) Query: 7 FLLVAQVSWAGPFQQKGLFDFMLEDEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVV 66 + +A+ S GP K LF +GI E P V +E + + HL Sbjct: 92 LIFMAETSLTGPKFLKHLFL-----TQTGISNLEFIP-VHNLENLESL-------HLGSN 138 Query: 67 QCSDLGLEKVPKDLPP-DTALLDLQNNKITEIKDGDFKNLKNLHTLILI--NNKISKISP 123 S + L P++ P + +LD QNN I I D +L+ L L N I I P Sbjct: 139 HISSINL---PENFPTQNLKVLDFQNNAIHYISRKDTNSLEQATNLSLNFNGNDIKGIEP 195 Query: 124 GAF-APLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITK---VRKSVFNGLNQMIV 179 GAF + + + + S N TLQ L + E T + + F GL M V Sbjct: 196 GAFISKIFQSLKFGGSLNLFIIFKGLQNSTLQSLWLGTFEDTDDQYLTSATFEGLCDMSV 255 Query: 180 VELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDA 239 + + S + + F+ ++ + + ++ +P G+ Sbjct: 256 ESINLQKHRFSDLSSSTFRCFTRVQELDLTAAHLNGLPSGI------------------- 296 Query: 240 ASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNN 280 +G+N+L KL L+ NS + + A+ P LR+L++ N Sbjct: 297 ---EGMNSLKKLVLNANSFDQLCQINAASFPSLRDLYIKGN 334 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 50/195 (25%), Positives = 85/195 (43%), Gaps = 23/195 (11%) Query: 87 LDLQNNKI--TEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLK- 143 LDL ++ I ++ + KNL++L L L N+ + AF +LE L ++ L Sbjct: 354 LDLSHSDIEASDCCNLQLKNLRHLQYLNLSYNEPLGLEDQAFKECPQLELLDVAFTHLHV 413 Query: 144 ELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKL 203 + P + L LRV + + + NQ ++ G L+ ++ +FQ Sbjct: 414 KAPHSPFQNLHLLRV-----LNLSHCLLDTSNQHLLA--GLQDLRHLNLQGNSFQDGS-- 464 Query: 204 SYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDN 263 I+ TN+ + SL L L + +D + GL N+ L LS NS++ Sbjct: 465 ----ISKTNLLQ----MVGSLEILILSSCNLLSIDQQAFHGLRNVNHLDLSHNSLTG--- 513 Query: 264 GSLANTPHLRELHLN 278 S+ HL+ L+LN Sbjct: 514 DSMDALSHLKGLYLN 528 >4AY9-X nrPDB Length = 350 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 60/232 (25%), Positives = 106/232 (45%), Gaps = 40/232 (17%) Query: 55 CPFR-CQCHLRVVQCSDLGLEKVPKDLPP------------------------DTALLDL 89 C R C C RV C + + ++P DLP D +++ Sbjct: 2 CHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEI 61 Query: 90 QNNKITEIKDGD-FKNLKNLHTL-ILINNKISKISPGAFAPLVKLERLYLSKNQLKELPE 147 N + E+ + D F NL LH + I N + I+P AF L L+ L +S +K LP+ Sbjct: 62 SQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD 121 Query: 148 -----KMPKTLQELRVHENEITKVRKSVFNGLN-QMIVVELGTNPLKSSGIENGAFQGMK 201 + K L +++ + N I + ++ F GL+ + +++ L N ++ I N AF G Sbjct: 122 VHKIHSLQKVLLDIQDNIN-IHTIERNSFVGLSFESVILWLNKNGIQE--IHNSAFNGT- 177 Query: 202 KLSYIRIAD-TNITTIPQGLPPSLT-ELHLDGNKITKVDAASLKGLNNLAKL 251 +L + ++D N+ +P + + + LD ++ T++ + GL NL KL Sbjct: 178 QLDELNLSDNNNLEELPNDVFHGASGPVILDISR-TRIHSLPSYGLENLKKL 228 >3A79-B nrPDB Length = 562 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 36/113 (31%), Positives = 55/113 (48%), Gaps = 1/113 (0%) Query: 51 MGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHT 110 +G + PF + +V S+ L VPKDLPP T L L N I+E++ D L L Sbjct: 22 VGSMTPFSNELE-SMVDYSNRNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELRV 80 Query: 111 LILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEI 163 L L +N+I + F LE L +S N+L+ + +L+ L + N+ Sbjct: 81 LRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNISCCPMASLRHLDLSFNDF 133 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 22/65 (33%), Positives = 35/65 (53%), Gaps = 1/65 (1%) Query: 76 VPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERL 135 V + LPP +LDL NN+I I D +L+ L L + +N++ + G F L L+ + Sbjct: 444 VFRCLPPKVKVLDLHNNRIMSIP-KDVTHLQALQELNVASNQLKSVPDGVFDRLTSLQYI 502 Query: 136 YLSKN 140 +L N Sbjct: 503 WLHDN 507 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 32/132 (24%), Positives = 59/132 (44%), Gaps = 17/132 (12%) Query: 204 SYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDN 263 S + ++ N+T +P+ LPP L L N I+++ + L+ L L LS N I ++D Sbjct: 34 SMVDYSNRNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIRSLDF 93 Query: 264 GSLANTPHLRELHLNNNKLVKVPGG-LADHKYIQVVYLHNNNISAIGSNDF-----CPPG 317 L L +++N+L + +A +++ + + NDF C Sbjct: 94 HVFLFNQDLEYLDVSHNRLQNISCCPMASLRHLDLSF-----------NDFDVLPVCKEF 142 Query: 318 YNTKKASYSGVS 329 N K ++ G+S Sbjct: 143 GNLTKLTFLGLS 154 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 18/58 (31%), Positives = 31/58 (53%), Gaps = 2/58 (3%) Query: 131 KLERLYLSKNQLKELPEKMP--KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNP 186 K++ L L N++ +P+ + + LQEL V N++ V VF+ L + + L NP Sbjct: 451 KVKVLDLHNNRIMSIPKDVTHLQALQELNVASNQLKSVPDGVFDRLTSLQYIWLHDNP 508 Score = 28.1 bits (61), Expect = 6.9, Method: Compositional matrix adjust. Identities = 33/148 (22%), Positives = 56/148 (37%), Gaps = 43/148 (29%) Query: 172 NGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIA-----------DTNITT--IPQ 218 NGL V L T + S + + + +Y R +N+ T + + Sbjct: 387 NGLKNFFKVALMTKNMSSLETLDVSLNSLNSHAYDRTCAWAESILVLNLSSNMLTGSVFR 446 Query: 219 GLPPSLTELHLDGNKITKV--DAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELH 276 LPP + L L N+I + D L+ L +EL+ Sbjct: 447 CLPPKVKVLDLHNNRIMSIPKDVTHLQAL---------------------------QELN 479 Query: 277 LNNNKLVKVPGGLADH-KYIQVVYLHNN 303 + +N+L VP G+ D +Q ++LH+N Sbjct: 480 VASNQLKSVPDGVFDRLTSLQYIWLHDN 507 Score = 27.7 bits (60), Expect = 9.1, Method: Compositional matrix adjust. Identities = 20/71 (28%), Positives = 36/71 (50%), Gaps = 3/71 (4%) Query: 57 FRCQC-HLRVVQCSDLGLEKVPKDLPPDTAL--LDLQNNKITEIKDGDFKNLKNLHTLIL 113 FRC ++V+ + + +PKD+ AL L++ +N++ + DG F L +L + L Sbjct: 445 FRCLPPKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNQLKSVPDGVFDRLTSLQYIWL 504 Query: 114 INNKISKISPG 124 +N PG Sbjct: 505 HDNPWDCTCPG 515 >2Z7X-B nrPDB Length = 520 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 73/275 (26%), Positives = 113/275 (41%), Gaps = 26/275 (9%) Query: 72 GLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVK 131 GL VPKDL T +L++ N I+E+ D +L L LI+ +N+I + F + Sbjct: 11 GLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQE 70 Query: 132 LERLYLSKNQLKELPEKMPKTLQELRVHENEITKV-RKSVFNGLNQMIVVELGTNPLKSS 190 LE L LS N+L ++ L+ L + N + F ++Q+ + L T L+ S Sbjct: 71 LEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKS 130 Query: 191 GIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTE-LHL---DGNKITKVDAASLKGLN 246 + A + K+ + P+GL TE LH+ + + S+K + Sbjct: 131 SVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVA 190 Query: 247 NLA----KLGLSFNSISAVDN--GSLANTPHLRELHLNN-----NKLVKVPGGLADHKYI 295 NL K L N S + L P L L LNN N +++ L + Sbjct: 191 NLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRI---LQLVWHT 247 Query: 296 QVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSL 330 V Y +N+ G DF + YSG SL Sbjct: 248 TVWYFSISNVKLQGQLDF-------RDFDYSGTSL 275 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 56/107 (52%), Gaps = 5/107 (4%) Query: 87 LDLQNNKIT-EIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKEL 145 LD+ N ++ + K GD K+L +L + +N ++ P +K+ L L N++K + Sbjct: 379 LDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKV--LDLHSNKIKSI 436 Query: 146 PEKMPK--TLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSS 190 P+++ K LQEL V N++ V +F+ L + + L TNP S Sbjct: 437 PKQVVKLEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTNPWDCS 483 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 41/158 (25%), Positives = 67/158 (42%), Gaps = 32/158 (20%) Query: 129 LVKLERLYLSKNQLKELPE-----KMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELG 183 L +LE L L NQLKEL + K+LQ+L + +N ++ K Sbjct: 347 LTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEK--------------- 391 Query: 184 TNPLKSSGIENGAFQGMKKLSYIRIADTNIT-TIPQGLPPSLTELHLDGNKITKVDAASL 242 G K L + ++ +T TI + LPP + L L NKI + + Sbjct: 392 ----------KGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVV 441 Query: 243 KGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNN 280 K L L +L ++ N + +V +G L+++ L+ N Sbjct: 442 K-LEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTN 478 Score = 35.0 bits (79), Expect = 0.049, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 39/72 (54%), Gaps = 1/72 (1%) Query: 69 SDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAP 128 S++ + + + LPP +LDL +NKI I K L+ L L + +N++ + G F Sbjct: 408 SNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVK-LEALQELNVASNQLKSVPDGIFDR 466 Query: 129 LVKLERLYLSKN 140 L L++++L N Sbjct: 467 LTSLQKIWLHTN 478 Score = 34.3 bits (77), Expect = 0.083, Method: Compositional matrix adjust. Identities = 39/149 (26%), Positives = 74/149 (49%), Gaps = 13/149 (8%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGA--FAPLVKLERLYLSKNQLKE 144 LD NN +T+ + +L L TLIL N++ ++S A + L++L +S+N + Sbjct: 329 LDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSY 388 Query: 145 LPEK----MPKTLQELRVHENEITKVRKSVFNGLNQMI-VVELGTNPLKSSGIENGAFQG 199 +K K+L L + N +T ++F L I V++L +N +KS + + Sbjct: 389 DEKKGDCSWTKSLLSLNMSSNILT---DTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEA 445 Query: 200 MKKLSYIRIADTNITTIPQGLPPSLTELH 228 +++L+ +A + ++P G+ LT L Sbjct: 446 LQELN---VASNQLKSVPDGIFDRLTSLQ 471 >5XJX-C nrPDB Length = 433 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 62/228 (27%), Positives = 97/228 (42%), Gaps = 31/228 (13%) Query: 86 LLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLK-E 144 +LDL N + F L +L L N+++ PG P L L L++N L Sbjct: 160 VLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLP--ALSVLDLNQNLLTGP 217 Query: 145 LPEKMPK--TLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKK 202 +P + +L ++ + N +T N LNQ+++++L N L SG + QG+ Sbjct: 218 VPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRL--SGPFPSSLQGLN- 274 Query: 203 LSYIRIADTNITTIPQGLPPSLTELHLDGNK--ITKVDAASLKGLNNLAKLGLSFNSISA 260 SL L L GN T + + KGL NL L LS +I Sbjct: 275 --------------------SLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQG 314 Query: 261 VDNGSLANTPHLRELHLNNNKLV-KVPGGLADHKYIQVVYLHNNNISA 307 SL LR LHL N L ++P D K++ + L++N+++ Sbjct: 315 SIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTG 362 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 48/187 (25%), Positives = 80/187 (42%), Gaps = 19/187 (10%) Query: 131 KLERLYLSKNQ-LKELPEKMPK--TLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPL 187 L+ L L +N L +P+++ L+ L +H+N + FN + + ++L N L Sbjct: 133 SLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRL 192 Query: 188 KSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLT------ELHLDGNKITKVDAAS 241 G+ G L + + D N + +PP+LT ++ L N++T S Sbjct: 193 ------TGSIPGFV-LPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPES 245 Query: 242 LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNK--LVKVP-GGLADHKYIQVV 298 + LN L L LS+N +S SL L+ L L N +P K + ++ Sbjct: 246 INRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMIL 305 Query: 299 YLHNNNI 305 L N NI Sbjct: 306 VLSNTNI 312 >1XWD-C nrPDB Length = 252 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 60/232 (25%), Positives = 106/232 (45%), Gaps = 40/232 (17%) Query: 55 CPFR-CQCHLRVVQCSDLGLEKVPKDLPP------------------------DTALLDL 89 C R C C RV C + + ++P DLP D +++ Sbjct: 2 CHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEI 61 Query: 90 QNNKITEIKDGD-FKNLKNLHTL-ILINNKISKISPGAFAPLVKLERLYLSKNQLKELPE 147 N + E+ + D F NL LH + I N + I+P AF L L+ L +S +K LP+ Sbjct: 62 SQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD 121 Query: 148 -----KMPKTLQELRVHENEITKVRKSVFNGLN-QMIVVELGTNPLKSSGIENGAFQGMK 201 + K L +++ + N I + ++ F GL+ + +++ L N ++ I N AF G Sbjct: 122 VHKIHSLQKVLLDIQDNIN-IHTIERNSFVGLSFESVILWLNKNGIQE--IHNCAFNGT- 177 Query: 202 KLSYIRIAD-TNITTIPQGLPPSLT-ELHLDGNKITKVDAASLKGLNNLAKL 251 +L + ++D N+ +P + + + LD ++ T++ + GL NL KL Sbjct: 178 QLDELNLSDNNNLEELPNDVFHGASGPVILDISR-TRIHSLPSYGLENLKKL 228 >1JL5-A nrPDB Length = 454 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 63/244 (25%), Positives = 110/244 (45%), Gaps = 43/244 (17%) Query: 63 LRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKIS 122 L+++ + L+K+P DLPP + NN++ E+ + +NL L + NN + K+ Sbjct: 155 LKIIDVDNNSLKKLP-DLPPSLEFIAAGNNQLEEL--PELQNLPFLTAIYADNNSLKKLP 211 Query: 123 --PGAFAPLVK----------------LERLYLSKNQLKELPEKMPKTLQELRVHENEIT 164 P + +V L +Y N LK LP+ +P +L+ L V +N +T Sbjct: 212 DLPLSLESIVAGNNILEELPELQNLPFLTTIYADNNLLKTLPD-LPPSLEALNVRDNYLT 270 Query: 165 KVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSL 224 + + + L + V S I +G + L Y+ + I ++ LPPSL Sbjct: 271 DLPE-LPQSLTFLDV---------SENIFSGLSELPPNLYYLNASSNEIRSL-CDLPPSL 319 Query: 225 TELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH-LRELHLNNNKLV 283 EL++ NK+ ++ A + L +L SFN ++ V P L++LH+ N L Sbjct: 320 EELNVSNNKLIELPALPPR----LERLIASFNHLAEV-----PELPQNLKQLHVEYNPLR 370 Query: 284 KVPG 287 + P Sbjct: 371 EFPD 374 Score = 36.6 bits (83), Expect = 0.019, Method: Compositional matrix adjust. Identities = 68/272 (25%), Positives = 119/272 (43%), Gaps = 63/272 (23%) Query: 66 VQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGA 125 ++ ++LGL +P +LPP L N +TE+ + ++L +L++ NN + +S Sbjct: 76 LELNNLGLSSLP-ELPPHLESLVASCNSLTELPELP----QSLKSLLVDNNNLKALS--D 128 Query: 126 FAPLVKLERLYLSKNQLKELPE---------------------KMPKTLQELRVHENEIT 164 PL LE L +S NQL++LPE +P +L+ + N++ Sbjct: 129 LPPL--LEYLGVSNNQLEKLPELQNSSFLKIIDVDNNSLKKLPDLPPSLEFIAAGNNQLE 186 Query: 165 KVRK--------SVFNGLNQMIVVELGTNPLKSSGIENG--------AFQGMKKLSYIRI 208 ++ + +++ N + +L PL I G Q + L+ I Sbjct: 187 ELPELQNLPFLTAIYADNNSL--KKLPDLPLSLESIVAGNNILEELPELQNLPFLTTI-Y 243 Query: 209 ADTNITTIPQGLPPSLTELHLDGNKITK------------VDAASLKGLNNLAKLGLSFN 256 AD N+ LPPSL L++ N +T V GL+ L L + Sbjct: 244 ADNNLLKTLPDLPPSLEALNVRDNYLTDLPELPQSLTFLDVSENIFSGLSELPP-NLYYL 302 Query: 257 SISAVDNGSLAN-TPHLRELHLNNNKLVKVPG 287 + S+ + SL + P L EL+++NNKL+++P Sbjct: 303 NASSNEIRSLCDLPPSLEELNVSNNKLIELPA 334 >3T6Q-A nrPDB Length = 606 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 86/210 (40%), Gaps = 32/210 (15%) Query: 64 RVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISP 123 + C +LGL ++P LP T L+ N + I++ F L NL L L +I I Sbjct: 15 KTYNCENLGLNEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIYWIHE 74 Query: 124 GAFAPLVKLERLYLSKNQLKELPEKM---PKTLQELRVHENEITKVRKSVFNGLNQMIVV 180 F +L+ L L+ N L + E PK L+ L + I+ + Sbjct: 75 DTFQSQHRLDTLVLTANPLIFMAETALSGPKALKHLFFIQTGISSI-------------- 120 Query: 181 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPS-LTELHLDGNKI---TK 236 PL + + G +S I+ +P+G P L L N I +K Sbjct: 121 --DFIPLHNQKTLESLYLGSNHISSIK--------LPKGFPTEKLKVLDFQNNAIHYLSK 170 Query: 237 VDAASLKGLNNLAKLGLSFNSISAVDNGSL 266 D +SL+ NL+ L L+ N I+ ++ G+ Sbjct: 171 EDMSSLQQATNLS-LNLNGNDIAGIEPGAF 199 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 84/215 (39%), Gaps = 33/215 (15%) Query: 75 KVPKDLPPDT-ALLDLQNNKITEIKDGDFKNLK---NLHTLILINNKISKISPGAFAPLV 130 K+PK P + +LD QNN I + D +L+ NL +L L N I+ I PGAF V Sbjct: 145 KLPKGFPTEKLKVLDFQNNAIHYLSKEDMSSLQQATNL-SLNLNGNDIAGIEPGAFDSAV 203 Query: 131 KLERLYLSKNQ-----LKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTN 185 + L Q K L ++L + + + +VF GL +M V + Sbjct: 204 -FQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGLCEMSVESINLQ 262 Query: 186 PLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGL 245 I + F L + + T+++ +P GL GL Sbjct: 263 KHYFFNISSNTFHCFSGLQELDLTATHLSELPSGLV----------------------GL 300 Query: 246 NNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNN 280 + L KL LS N + S +N P L L + N Sbjct: 301 STLKKLVLSANKFENLCQISASNFPSLTHLSIKGN 335 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 76/323 (23%), Positives = 135/323 (41%), Gaps = 38/323 (11%) Query: 12 QVSWAGPFQQK-------GLFDFMLEDEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLR 64 Q W G F+ +F+ + E I ++H+ I F C L+ Sbjct: 228 QSLWLGTFEDMDDEDISPAVFEGLCEMSVESINLQKHY--FFNISSN----TFHCFSGLQ 281 Query: 65 VVQCSDLGLEKVPKDLPPDTAL--LDLQNNK---ITEIKDGDFKNLKNLHTLILINNKIS 119 + + L ++P L + L L L NK + +I +F +L H I N K Sbjct: 282 ELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLT--HLSIKGNTKRL 339 Query: 120 KISPGAFAPLVKLERLYLSKNQLK-----ELPEKMPKTLQELRVHENEITKVRKSVFNGL 174 ++ G L L L LS + ++ L + LQ L + NE ++ F Sbjct: 340 ELGTGCLENLENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKEC 399 Query: 175 NQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIA----DTNITTIPQGLPPSLTELHLD 230 Q+ +++L LK + FQ + L + ++ D + + GLP +L L+L Sbjct: 400 PQLELLDLAFTRLKVKDAQ-SPFQNLHLLKVLNLSHSLLDISSEQLFDGLP-ALQHLNLQ 457 Query: 231 GNKITKVD---AASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPG 287 GN K + SL+ L L L LSF +S++D + + + + L++N+L Sbjct: 458 GNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTS--S 515 Query: 288 GLADHKYIQVVYLH--NNNISAI 308 + +++ +YL+ +N+IS I Sbjct: 516 SIEALSHLKGIYLNLASNHISII 538 >6O00-A nrPDB Length = 820 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 76/314 (24%), Positives = 139/314 (44%), Gaps = 49/314 (15%) Query: 82 PDTA--LLDLQNNKITEIKDG----DFKNLKNLHTLILINNKISKISPGAFAPLVK-LER 134 PDT L++L+ K+ I D L L L L + +KI A A L + L Sbjct: 439 PDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA-AKIEAPALAFLRENLRA 497 Query: 135 LYLSKNQLKELPEKMP--KTLQELRVHEN-EITKVRKSVFNGLNQM-------------- 177 L++ +KE+P + KTL+EL + N R V +GL ++ Sbjct: 498 LHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSK 557 Query: 178 ---IVVELGTNPLKSSGIENG-------AFQGMKKLSYIRIADTNITTIPQGLPP--SLT 225 +V ++G + K S G + + M L+ + + ++ IP + +L Sbjct: 558 LPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQ 617 Query: 226 ELHLDGNKITKVDAA-SLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVK 284 E+ L N + ++ S + L+ L L L +N I+ + + N +L L+LN NK+ K Sbjct: 618 EIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIP-IQIGNLTNLERLYLNRNKIEK 676 Query: 285 VPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPST 344 +P L + ++ + L +NN++ F P + + +++ +N ++ + P Sbjct: 677 IPTQLFYCRKLRYLDLSHNNLT------FLPADIGLLQ-NLQNLAVTANRIE--ALPPEL 727 Query: 345 FRCVYVRAAVQLGN 358 F+C +R A+ LGN Sbjct: 728 FQCRKLR-ALHLGN 740 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 90/201 (44%), Gaps = 11/201 (5%) Query: 114 INNKISK-ISPGAFAPLVKLERLYLSKNQLKELPEKM--PKTLQELRVHENEITKVRKSV 170 INN+ +K I + +V L L L + L+ +P + LQE+ + +N + + + + Sbjct: 574 INNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEII 633 Query: 171 -FNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGL--PPSLTEL 227 F L+++ ++L N + I+ G +++L R I IP L L L Sbjct: 634 SFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR---NKIEKIPTQLFYCRKLRYL 690 Query: 228 HLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPG 287 L N +T + A + L NL L ++ N I A+ L LR LHL NN L +P Sbjct: 691 DLSHNNLTFL-PADIGLLQNLQNLAVTANRIEALP-PELFQCRKLRALHLGNNVLQSLPS 748 Query: 288 GLADHKYIQVVYLHNNNISAI 308 + + + + L N + + Sbjct: 749 RVGELTNLTQIELRGNRLECL 769 >3G04-C nrPDB Length = 239 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 63/246 (25%), Positives = 115/246 (46%), Gaps = 43/246 (17%) Query: 59 CQCHLR---VVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTL-ILI 114 C+CH V C D+ +++P LPP T L L + I F NL N+ + + I Sbjct: 8 CECHQEEDFRVTCKDI--QRIPS-LPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSI 64 Query: 115 NNKISKISPGAFAPLVKLERL---------YLSKNQLKELPEKMPKTLQELRVHEN---- 161 + + ++ +F L K+ + Y+ + LKELP L+ L + Sbjct: 65 DVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELP-----LLKFLGIFNTGLKM 119 Query: 162 --EITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGM-KKLSYIRIADTNITTIPQ 218 ++TKV + + ++E+ NP +S I AFQG+ + +++ + T++ Q Sbjct: 120 FPDLTKVYST-----DIFFILEITDNPYMTS-IPVNAFQGLCNETLTLKLYNNGFTSV-Q 172 Query: 219 GLPPSLTEL---HLDGNK-ITKVDAASLKGL-NNLAKLGLSFNSISAVDNGSLANTPHLR 273 G + T+L +L+ NK +T +D + G+ + + L +S S++A+ + L HL+ Sbjct: 173 GYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLE---HLK 229 Query: 274 ELHLNN 279 EL N Sbjct: 230 ELIARN 235 >1M9S-A nrPDB Length = 605 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 30/64 (46%), Positives = 36/64 (56%), Gaps = 4/64 (6%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 P L L NNKIT+I L L TL L +N+IS I P A L KL+ LYLSKN Sbjct: 131 PQLESLYLGNNKITDITV--LSRLTKLDTLSLEDNQISDIVP--LAGLTKLQNLYLSKNH 186 Query: 142 LKEL 145 + +L Sbjct: 187 ISDL 190 Score = 32.3 bits (72), Expect = 0.32, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 46/107 (42%), Gaps = 23/107 (21%) Query: 222 PSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAV-------------------- 261 P++T+L L+GNK+T D L L NL L L N I + Sbjct: 65 PNVTKLFLNGNKLT--DIKPLTNLKNLGWLFLDENKIKDLSSLKDLKKLKSLSLEHNGIS 122 Query: 262 DNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAI 308 D L + P L L+L NNK+ + L+ + + L +N IS I Sbjct: 123 DINGLVHLPQLESLYLGNNKITDIT-VLSRLTKLDTLSLEDNQISDI 168 Score = 28.1 bits (61), Expect = 6.2, Method: Compositional matrix adjust. Identities = 31/107 (28%), Positives = 47/107 (43%), Gaps = 25/107 (23%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISP------------------ 123 P+ L L NK+T+IK NLKNL L L NKI +S Sbjct: 65 PNVTKLFLNGNKLTDIKP--LTNLKNLGWLFLDENKIKDLSSLKDLKKLKSLSLEHNGIS 122 Query: 124 --GAFAPLVKLERLYLSKNQLKELP--EKMPKTLQELRVHENEITKV 166 L +LE LYL N++ ++ ++ K L L + +N+I+ + Sbjct: 123 DINGLVHLPQLESLYLGNNKITDITVLSRLTK-LDTLSLEDNQISDI 168 >6HKW-A nrPDB Length = 363 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 102/225 (45%), Gaps = 38/225 (16%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 + +LD+ N + I+ D L L L L+NNKISKI + L +L+ L L N+ Sbjct: 145 TELEILDISFNLLRNIEGVD--KLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNR 200 Query: 142 LKELPEKMPKT-LQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGM 200 ++ + T L+ L + +N+ITK++ + L + V+ + +N L +G+ Sbjct: 201 IRAIENIDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRL-------TKIEGL 251 Query: 201 KKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISA 260 + L +R EL+L N I ++ L+ N L L ++ N I Sbjct: 252 QNLVNLR------------------ELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKK 291 Query: 261 VDNGSLANTPHLRELHLNNNKLVKVP--GGLADHKYIQVVYLHNN 303 ++N +++ L+E +N+N L L + ++ VYL N Sbjct: 292 IEN--ISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERN 334 >3JB9-j nrPDB Length = 239 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 22/64 (34%), Positives = 37/64 (57%), Gaps = 2/64 (3%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELP 146 +D +N I + G+F +K L TL+ NN+I+ I+P L L+ L L++N L+E+ Sbjct: 46 IDFTDNDIRYL--GNFPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIA 103 Query: 147 EKMP 150 + P Sbjct: 104 DLDP 107 >3G06-A nrPDB Length = 622 Score = 36.6 bits (83), Expect = 0.017, Method: Compositional matrix adjust. Identities = 59/258 (22%), Positives = 110/258 (42%), Gaps = 33/258 (12%) Query: 61 CHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISK 120 H+ + D L +P LPP+ L++ N++T + L L + +N ++ Sbjct: 61 AHITTLVIPDNNLTSLPA-LPPELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTH 115 Query: 121 ISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKV--------RKSVFN 172 + P + L KL ++ NQL LP +P LQEL V +N++ + + +N Sbjct: 116 L-PALPSGLCKL---WIFGNQLTSLP-VLPPGLQELSVSDNQLASLPALPSELCKLWAYN 170 Query: 173 GLNQMIVVELGTNPLKSSGIENGAFQGM----KKLSYIRIADTNITTIPQGLPPSLTELH 228 NQ+ + + + L+ + + + +L + + +T++P LP L EL Sbjct: 171 --NQLTSLPMLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLP-ALPSGLKELI 227 Query: 229 LDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGG 288 + GN++T + L L G S+ + +G L+ L + N+L ++P Sbjct: 228 VSGNRLTSLPVLP-SELKELMVSGNRLTSLPMLPSGLLS-------LSVYRNQLTRLPES 279 Query: 289 LADHKYIQVVYLHNNNIS 306 L V L N +S Sbjct: 280 LIHLSSETTVNLEGNPLS 297 >4PBV-A nrPDB Length = 268 Score = 35.4 bits (80), Expect = 0.036, Method: Compositional matrix adjust. Identities = 38/123 (30%), Positives = 58/123 (47%), Gaps = 25/123 (20%) Query: 55 CPFRCQCHLRVVQCSDLGLEKVPKD--LPPDTALLDLQNNK-ITEIKDGDFKNLKNLHT- 110 CP C C + C K P D L P LL+ Q+++ IT I ++KNL+ L+ Sbjct: 4 CPANCLCSKTDINC------KKPDDGNLFP---LLEGQDSRNITSIHIENWKNLQTLNAV 54 Query: 111 ----------LILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQ--ELRV 158 L + N+ + I P AFA L + LS N+L L ++ +TL+ +LR+ Sbjct: 55 DMELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQTLRLFDLRL 114 Query: 159 HEN 161 N Sbjct: 115 ERN 117 >6ICZ-o nrPDB Length = 255 Score = 34.7 bits (78), Expect = 0.062, Method: Compositional matrix adjust. Identities = 37/122 (30%), Positives = 58/122 (47%), Gaps = 9/122 (7%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELP 146 +D +N+I ++ DG F L+ L TL++ NN+I +I G L L L L+ N L EL Sbjct: 47 IDFSDNEIRKL-DG-FPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELG 104 Query: 147 EKMP----KTLQELRVHENEITK---VRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQG 199 + P K+L L + N +T R V + Q+ V++ LK F+G Sbjct: 105 DLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQEAEKMFKG 164 Query: 200 MK 201 + Sbjct: 165 KR 166 >5LJ5-W nrPDB Length = 238 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 31/112 (27%), Positives = 55/112 (49%), Gaps = 16/112 (14%) Query: 64 RVVQCSDLGLEKVPKDLPPD-------TALLDLQNNKITEIKDGDFKNLKNLHTLILINN 116 + V DL LE + +P T +LDL NN + I D ++ ++HTL+L N Sbjct: 27 KCVILRDLQLETDSESMPSSLKHLTKPTHILDLTNNDLIMIPDLSRRD--DIHTLLLGRN 84 Query: 117 KISKISPGAFAPLVKLERLYLSKNQLKELPE-----KMPKTLQELRVHENEI 163 I ++ G P+ ++ L LS N ++ + + P+TL+ L + N++ Sbjct: 85 NIVEVD-GRLLPM-NVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQV 134 >3JCM-G nrPDB Length = 899 Score = 33.1 bits (74), Expect = 0.22, Method: Compositional matrix adjust. Identities = 21/98 (21%), Positives = 47/98 (47%), Gaps = 8/98 (8%) Query: 86 LLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLE----RLYLSK-- 139 L DL+N+++ + D ++L+ + T++ K +P + +LE + ++K Sbjct: 204 LKDLENDRVNSLSDATLEDLQKMRTILKSYRKADPTNPQGWIASARLEEKARKFSVAKKI 263 Query: 140 --NQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLN 175 N +E P L+ +R+HE+++ + V +N Sbjct: 264 IENGCQECPRSSDIWLENIRLHESDVHYCKTLVATAIN 301 >2Q4G-W nrPDB Length = 461 Score = 32.3 bits (72), Expect = 0.36, Method: Compositional matrix adjust. Identities = 19/57 (33%), Positives = 28/57 (49%), Gaps = 6/57 (10%) Query: 264 GSLANTPHLRELHLNNNKLVKV------PGGLADHKYIQVVYLHNNNISAIGSNDFC 314 G +A+ LREL L +NKL V PG L ++ +++ I+A G D C Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLC 277 >2BNH-A nrPDB Length = 457 Score = 31.6 bits (70), Expect = 0.50, Method: Compositional matrix adjust. Identities = 32/99 (32%), Positives = 48/99 (48%), Gaps = 16/99 (16%) Query: 200 MKKLSYIRIADTNITT-----IPQGLP--PSLTELHLDGNKITKVDA-ASLKGLNN---- 247 +++ +R+ D +T I L PSLTEL L N++ L+GL + Sbjct: 23 LQQYEVVRLDDCGLTEEHCKDIGSALRANPSLTELCLRTNELGDAGVHLVLQGLQSPTCK 82 Query: 248 LAKLGLSFNSISAVDNGSLANT----PHLRELHLNNNKL 282 + KL L S++ G L +T P LRELHL++N L Sbjct: 83 IQKLSLQNCSLTEAGCGVLPSTLRSLPTLRELHLSDNPL 121 >4ECN-A nrPDB Length = 876 Score = 31.6 bits (70), Expect = 0.58, Method: Compositional matrix adjust. Identities = 56/265 (21%), Positives = 106/265 (40%), Gaps = 30/265 (11%) Query: 44 EVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEI-KDGDF 102 ++PE++ + C + L ++ D P + + N + E Sbjct: 513 DLPELQSLNIACNRGISAAQLKADWTRLADDE---DTGPKIQIFYMGYNNLEEFPASASL 569 Query: 103 KNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEK---MPKTLQELRVH 159 + + L L ++NK+ + AF VKL L L NQ++E+PE ++ L Sbjct: 570 QKMVKLGLLDCVHNKVRHLE--AFGTNVKLTDLKLDYNQIEEIPEDFCAFTDQVEGLGFS 627 Query: 160 ENEITKVRKSVFNGLNQMIV--VELGTNPLKSSG----IENGAFQGMK----KLSYIRIA 209 N++ K ++FN + ++ V+ N + S G ++G+ LSY I Sbjct: 628 HNKL-KYIPNIFNAKSVYVMGSVDFSYNKIGSEGRNISCSMDDYKGINASTVTLSYNEIQ 686 Query: 210 DTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNN-------LAKLGLSFNSISAVD 262 G P ++ + L N +T + SLK + L + L FN ++++ Sbjct: 687 KFPTELFATGSP--ISTIILSNNLMTSIPENSLKPKDGNYKNTYLLTTIDLRFNKLTSLS 744 Query: 263 NGSLANT-PHLRELHLNNNKLVKVP 286 + A T P+L + ++ N P Sbjct: 745 DDFRATTLPYLSNMDVSYNCFSSFP 769 Score = 29.6 bits (65), Expect = 1.9, Method: Compositional matrix adjust. Identities = 41/159 (25%), Positives = 64/159 (40%), Gaps = 26/159 (16%) Query: 101 DFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPE----------KMP 150 D+K + N T+ L N+I K FA + + LS N + +PE K Sbjct: 669 DYKGI-NASTVTLSYNEIQKFPTELFATGSPISTIILSNNLMTSIPENSLKPKDGNYKNT 727 Query: 151 KTLQELRVHENEITKV----RKSVFNGLNQMIVV-----ELGTNPLKSSGIENGAFQGMK 201 L + + N++T + R + L+ M V T PL SS ++ + + Sbjct: 728 YLLTTIDLRFNKLTSLSDDFRATTLPYLSNMDVSYNCFSSFPTQPLNSSQLKAFGIRHQR 787 Query: 202 KLSYIRIADTNITTIPQGLP--PSLTELHLDGNKITKVD 238 RI + P G+ PSL +L + N I KVD Sbjct: 788 DAEGNRI----LRQWPTGITTCPSLIQLQIGSNDIRKVD 822 >6EZB-A nrPDB Length = 327 Score = 31.6 bits (70), Expect = 0.62, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 34/77 (44%), Gaps = 2/77 (2%) Query: 258 ISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPG 317 +S VD + + R N++V G + + V L N+++ I N CP Sbjct: 54 LSTVDFVAPDDRVVFRTCEREQNRVVFQMGTSDAERALAVARLVENDVAGIDVNMGCPKQ 113 Query: 318 YNTKKASYSGVSLFSNP 334 Y+TK G +L S+P Sbjct: 114 YSTKGG--MGAALLSDP 128 >4PBW-B nrPDB Length = 283 Score = 31.2 bits (69), Expect = 0.77, Method: Compositional matrix adjust. Identities = 33/130 (25%), Positives = 53/130 (40%), Gaps = 24/130 (18%) Query: 55 CPFRCQCHLRVVQCSD----------LGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKN 104 CP C C + C G + + + D+ N IT I ++KN Sbjct: 4 CPANCLCSKTDINCKKPDDGNLFPLLEGQDSGSSNGQTSIQITDISRN-ITSIHIENWKN 62 Query: 105 LKNLHT-----------LILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTL 153 L+ L+ L + N+ + I P AFA L + LS N+L L ++ +TL Sbjct: 63 LQTLNAVDMELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQTL 122 Query: 154 Q--ELRVHEN 161 + +LR+ N Sbjct: 123 RLFDLRLERN 132 >2YKV-A nrPDB Length = 465 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 26/125 (20%), Positives = 49/125 (39%), Gaps = 17/125 (13%) Query: 98 KDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELR 157 +DG F + NN I +S G A L++ ++ + + R Sbjct: 325 RDGAFAHAGTF------NNNILTMSAGHAA---------LTQIYTRQAASDLSASGDRFR 369 Query: 158 VHENEITKVRKS--VFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITT 215 + N I ++ F GL + + P++S+G A Q +K+L + + I Sbjct: 370 ANLNRIAVENQAPLQFTGLGSLGTIHFSRAPIRSAGDVRAADQQLKELFFFHMLRKGIYL 429 Query: 216 IPQGL 220 P+G+ Sbjct: 430 APRGM 434 >1DCE-A nrPDB Length = 567 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 23/59 (38%), Positives = 32/59 (54%), Gaps = 3/59 (5%) Query: 224 LTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKL 282 +T L L N++ + A L L L L S N++ VD +AN P L+EL L NN+L Sbjct: 465 VTHLDLSHNRLRALPPA-LAALRCLEVLQASDNALENVDG--VANLPRLQELLLCNNRL 520 >2QM3-A nrPDB Length = 373 Score = 29.3 bits (64), Expect = 2.7, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 37/78 (47%), Gaps = 4/78 (5%) Query: 133 ERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGI 192 E LY N +KE+ E++ KT ++ V+E + V +V + +V+L PL + Sbjct: 16 ENLYFQSNAMKEIVERV-KTKTKIPVYERSVENVLSAVLASDDIWRIVDLSEEPLP---L 71 Query: 193 ENGAFQGMKKLSYIRIAD 210 + + +L Y+ D Sbjct: 72 VVAILESLNELGYVTFED 89 >1K05-A nrPDB Length = 162 Score = 28.1 bits (61), Expect = 5.8, Method: Compositional matrix adjust. Identities = 20/61 (32%), Positives = 33/61 (54%), Gaps = 7/61 (11%) Query: 72 GLEKVPKDL-PPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLV 130 G++ P+++ PP TA LD N+K+ E G K +I +++KI P + P+V Sbjct: 11 GVKLQPQEISPPPTANLDRSNDKVYENVTGLVK------AVIEMSSKIQPAPPEEYVPMV 64 Query: 131 K 131 K Sbjct: 65 K 65 >3TSR-E nrPDB Length = 457 Score = 28.1 bits (61), Expect = 6.5, Method: Compositional matrix adjust. Identities = 29/87 (33%), Positives = 42/87 (48%), Gaps = 12/87 (13%) Query: 203 LSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAA-SLKGLNN----LAKLGLSFNS 257 L+ +R D I++ Q P+LTEL L N++ L+GL N + KL L Sbjct: 36 LTEVRCKD--ISSAVQA-NPALTELSLRTNELGDGGVGLVLQGLQNPTCKIQKLSLQNCG 92 Query: 258 ISAVDNG----SLANTPHLRELHLNNN 280 ++ G L + LRELHLN+N Sbjct: 93 LTEAGCGILPGMLRSLSTLRELHLNDN 119 >5KH1-A nrPDB Length = 591 Score = 28.1 bits (61), Expect = 6.9, Method: Compositional matrix adjust. Identities = 24/81 (29%), Positives = 43/81 (53%), Gaps = 9/81 (11%) Query: 206 IRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGS 265 I I+ N++ I LP SLT+L++ N++ ++ A L L S N + + Sbjct: 92 INISKNNLSLI-SPLPASLTQLNVSYNRLIELPALP----QGLKLLNASHNQLITLPTLP 146 Query: 266 LANTPHLRELHLNNNKLVKVP 286 ++ L+ELH++NN+L +P Sbjct: 147 IS----LKELHVSNNQLCSLP 163 >6ACN-A nrPDB Length = 754 Score = 27.7 bits (60), Expect = 8.0, Method: Compositional matrix adjust. Identities = 18/46 (39%), Positives = 25/46 (54%), Gaps = 2/46 (4%) Query: 204 SYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLA 249 S+ RI +TN+ QGL P D NKI VD +++GL + A Sbjct: 663 SFARIHETNLKK--QGLLPLTFADPADYNKIHPVDKLTIQGLKDFA 706 >3VCY-A nrPDB Length = 430 Score = 27.3 bits (59), Expect = 9.7, Method: Compositional matrix adjust. Identities = 26/106 (24%), Positives = 45/106 (42%), Gaps = 19/106 (17%) Query: 241 SLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYL 300 ++ G N A L + F S+ A + +AN P LR++ L ++ ++ + + Sbjct: 18 TISGAKN-AALPILFASLLAEEPVEVANVPKLRDVDTTMELLKRLGAEVSRNGSV----- 71 Query: 301 HNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPSTFR 346 +I A G NDFC P Y+ K + + W + P R Sbjct: 72 ---HIDASGVNDFCAP-YDLVKTMRASI---------WALGPLVAR 104 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1XCD-A nrPDB 415 e-116 2FT3-A nrPDB 363 e-101 5YQ5-A nrPDB 224 4e-59 5MX0-A nrPDB 208 5e-54 4QDH-A nrPDB 176 2e-44 4R08-A nrPDB 175 2e-44 5Y3K-A nrPDB 174 4e-44 6O00-A nrPDB 173 1e-43 5ZSN-B nrPDB 171 5e-43 3WPI-A nrPDB 167 7e-42 5LFN-A nrPDB 166 2e-41 3CIG-A nrPDB 166 2e-41 6GFF-I nrPDB 160 7e-40 5Y3M-A nrPDB 159 1e-39 3ULU-A nrPDB 156 2e-38 6HLU-A nrPDB 155 3e-38 4PUF-A nrPDB 154 7e-38 2Z7X-B nrPDB 151 3e-37 3B2D-A nrPDB 150 8e-37 5XJX-C nrPDB 147 7e-36 4R6F-A nrPDB 142 2e-34 2XOT-A nrPDB 139 2e-33 3J0A-A nrPDB 136 1e-32 2V9T-B nrPDB 136 1e-32 3RG1-A nrPDB 135 3e-32 5Y31-B nrPDB 134 7e-32 3T6Q-A nrPDB 132 2e-31 3A79-B nrPDB 126 2e-29 3V44-A nrPDB 123 1e-28 4AY9-X nrPDB 117 8e-27 5GY2-A nrPDB 115 4e-26 2Z80-A nrPDB 113 2e-25 2Z7X-A nrPDB 110 6e-25 3A7C-A nrPDB 110 1e-24 5D3I-A nrPDB 109 2e-24 1JL5-A nrPDB 109 3e-24 1XWD-C nrPDB 107 1e-23 3G04-C nrPDB 102 3e-22 1M9S-A nrPDB 79 2e-15 Sequences not found previously or not previously below threshold: 3G06-A nrPDB 109 3e-24 6HKW-A nrPDB 107 7e-24 5KH1-A nrPDB 88 7e-18 4ECN-A nrPDB 82 2e-16 3CVR-A nrPDB 80 2e-15 1OGQ-A nrPDB 79 3e-15 5YXM-A nrPDB 64 9e-11 2BNH-A nrPDB 64 1e-10 4PEQ-B nrPDB 62 3e-10 4PBW-B nrPDB 61 6e-10 4PBV-A nrPDB 60 1e-09 2IFG-A nrPDB 57 2e-08 2Q4G-W nrPDB 53 3e-07 6ICZ-o nrPDB 52 3e-07 2CA6-A nrPDB 50 1e-06 3JB9-j nrPDB 49 2e-06 1DCE-A nrPDB 49 4e-06 6J5T-G nrPDB 47 1e-05 3TSR-E nrPDB 46 3e-05 5LJ5-W nrPDB 42 5e-04 6MDV-A nrPDB 40 0.001 1KOH-A nrPDB 40 0.002 4WYK-A nrPDB 39 0.003 6FE8-D nrPDB 37 0.011 4NUY-A nrPDB 37 0.011 4K17-A nrPDB 34 0.11 1OWP-A nrPDB 32 0.38 1USY-C nrPDB 30 2.2 2P1O-B nrPDB 29 2.4 2A90-A nrPDB 29 2.7 5MG8-B nrPDB 29 2.8 4GIP-D nrPDB 28 6.8 >1XCD-A nrPDB Length = 329 Score = 415 bits (1067), Expect = e-116, Method: Composition-based stats. Identities = 329/329 (100%), Positives = 329/329 (100%) Query: 31 DEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQ 90 DEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQ Sbjct: 1 DEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQ 60 Query: 91 NNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMP 150 NNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMP Sbjct: 61 NNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMP 120 Query: 151 KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIAD 210 KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIAD Sbjct: 121 KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIAD 180 Query: 211 TNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTP 270 TNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTP Sbjct: 181 TNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTP 240 Query: 271 HLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSL 330 HLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSL Sbjct: 241 HLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSL 300 Query: 331 FSNPVQYWEIQPSTFRCVYVRAAVQLGNY 359 FSNPVQYWEIQPSTFRCVYVRAAVQLGNY Sbjct: 301 FSNPVQYWEIQPSTFRCVYVRAAVQLGNY 329 >2FT3-A nrPDB Length = 332 Score = 363 bits (932), Expect = e-101, Method: Composition-based stats. Identities = 184/332 (55%), Positives = 243/332 (73%), Gaps = 2/332 (0%) Query: 30 EDEASGIGPEEHFPEVPEIEPM-GPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLD 88 ++EASG P++ + P +CPF C CHLRVVQCSDLGL+ VPK++ PDT LLD Sbjct: 1 DEEASGAETTSGIPDLDSLPPTYSAMCPFGCHCHLRVVQCSDLGLKAVPKEISPDTTLLD 60 Query: 89 LQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEK 148 LQNN I+E++ DFK L++L+ L+L+NNKISKI AF+PL KL++LY+SKN L E+P Sbjct: 61 LQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPN 120 Query: 149 MPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRI 208 +P +L ELR+H+N I KV K VF+GL M +E+G NPL++SG E GAF G+ KL+Y+RI Sbjct: 121 LPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGL-KLNYLRI 179 Query: 209 ADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLAN 268 ++ +T IP+ LP +L ELHLD NKI ++ L + L +LGL N I ++NGSL+ Sbjct: 180 SEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSF 239 Query: 269 TPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGV 328 P LRELHL+NNKL +VP GL D K +QVVYLH NNI+ +G NDFCP G+ K+A Y+G+ Sbjct: 240 LPTLRELHLDNNKLSRVPAGLPDLKLLQVVYLHTNNITKVGVNDFCPVGFGVKRAYYNGI 299 Query: 329 SLFSNPVQYWEIQPSTFRCVYVRAAVQLGNYK 360 SLF+NPV YWE+QP+TFRCV R A+Q GNYK Sbjct: 300 SLFNNPVPYWEVQPATFRCVTDRLAIQFGNYK 331 >5YQ5-A nrPDB Length = 430 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 83/309 (26%), Positives = 145/309 (46%), Gaps = 16/309 (5%) Query: 39 EEHFPEVPEIEPMGPV------CPFRCQCHLRV---VQCSDLGLEKVPKDLPPDTALLDL 89 + FP ++ P C C C + C + L+ +P ++P L L Sbjct: 38 QTGFPFRQNVDYGVPFHQYTLGCVSECFCPTNFPSSMYCDNRKLKTIP-NIPMHIQQLYL 96 Query: 90 QNNKITEIKDGDFKNLKNLHTLILINNKI--SKISPGAFAPLVKLERLYLSKNQLKELPE 147 Q N+I + F N +L + L +NKI KI G FA L L +L+L N L+E P Sbjct: 97 QFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNNLEEFPF 156 Query: 148 KMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIR 207 +PK+L+ L + NEI+K++ + +GL + +++L N L S +++ F M+KL + Sbjct: 157 PLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLN 216 Query: 208 IADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLA 267 + + ++P GLP SL L L+ N I+ + L L L +S N + + ++ Sbjct: 217 LCSNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIP-YNIF 275 Query: 268 NTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSG 327 N P++ EL + +NKL + + ++ +YL NN I + CP + Sbjct: 276 NLPNIVELSVGHNKLKQ---AFYIPRNLEHLYLQNNEIEKMNLTVMCPSIDPLHYHHLTY 332 Query: 328 VSLFSNPVQ 336 + + N ++ Sbjct: 333 IRVDQNKLK 341 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 40/126 (31%), Gaps = 50/126 (39%) Query: 68 CSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAF- 126 CS+ LE +P LP L L+NN I+ I + F L LHTL + +NK+ I F Sbjct: 218 CSNR-LESMPPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYNIFN 276 Query: 127 ------------------------------------------------APLVKLERLYLS 138 L + + Sbjct: 277 LPNIVELSVGHNKLKQAFYIPRNLEHLYLQNNEIEKMNLTVMCPSIDPLHYHHLTYIRVD 336 Query: 139 KNQLKE 144 +N+LKE Sbjct: 337 QNKLKE 342 >5MX0-A nrPDB Length = 362 Score = 208 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 84/333 (25%), Positives = 154/333 (46%), Gaps = 13/333 (3%) Query: 30 EDEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRV---VQCSDLGLEKVPKDLPPDTAL 86 E SG+ P CP C C + C + L+ +P +P Sbjct: 37 EPSPSGVDEGPASTSGSPSPPDPRDCPQECDCPPNFPTAMYCDNRNLKYLP-FVPSRMKY 95 Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKIS--KISPGAFAPLVKLERLYLSKNQLKE 144 + QNN+IT I++G F N L + L N+I+ K+ F+ L LERLYL N L Sbjct: 96 VYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTR 155 Query: 145 LPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLS 204 +P +P++L+EL + N+I++V + GL + + L N ++ G + +G++ L Sbjct: 156 MPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEVG---SSMRGLRSLI 212 Query: 205 YIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNG 264 + ++ ++ +P GLP +L +L+++ N + V + +G L + LS NS++ Sbjct: 213 LLDLSYNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLTNNGLA 272 Query: 265 SLA-NTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKA 323 S N+ L EL L+ N+L K+P ++ +YL N I+ + FC + Sbjct: 273 SNTFNSSSLLELDLSYNQLQKIPPVN---TNLENLYLQGNRINEFSISSFCTVVDVVNFS 329 Query: 324 SYSGVSLFSNPVQYWEIQPSTFRCVYVRAAVQL 356 + L N ++ + C+ + + +++ Sbjct: 330 KLQVLRLDGNEIKRSAMPADAPLCLRLASLIEI 362 >4QDH-A nrPDB Length = 438 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 85/353 (24%), Positives = 136/353 (38%), Gaps = 66/353 (18%) Query: 48 IEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKN 107 +P G CP RC C ++C+ GL VP +P L+L++NK+ + G F L Sbjct: 1 ADPGGKACPSRCSCSGTEIRCNSKGLTSVPTGIPSSATRLELESNKLQSLPHGVFDKLTQ 60 Query: 108 LHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKEL---PEKMP-KTLQELRVHENEI 163 L L L N + I P F L +L+ L LS N + + + +P LQ L + N++ Sbjct: 61 LTKLSLSRNNLVTIKPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKL 120 Query: 164 TKVRKSVFNGLNQMIVVELGTN--PLKSSGI-ENGAF-QGMKKLSYIRIADTNI-TTIPQ 218 F+ L Q+ ++L N P GI N +F + L + +A +I T + Sbjct: 121 DLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHNFSFVTHLSMLQSLSLAHNDIHTRVSS 180 Query: 219 GLP-PSLTELHLDGNKITKVDAAS------LKGLNNLAKLGLSFNSISAVDNG------- 264 L S+ L GN + ++ +GL+ L KL LS N++ + Sbjct: 181 HLNSNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPK 240 Query: 265 ------------------SLANTPHLRELHLNNNKLVKV--------------------- 285 SL+ P+L L L N+L + Sbjct: 241 SLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSI 300 Query: 286 ----PGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNP 334 P A ++ V L +N + + + F P N K+ + L S P Sbjct: 301 VSVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMNLKELALDTNQLKSVP 353 Score = 36.2 bits (82), Expect = 0.020, Method: Composition-based stats. Identities = 16/66 (24%), Positives = 26/66 (39%), Gaps = 4/66 (6%) Query: 55 CPFRCQCHLRVVQCSDLGLEKVPKD----LPPDTALLDLQNNKITEIKDGDFKNLKNLHT 110 F L+ V S L+ V + + + L L N++ + DG F L +L Sbjct: 306 AFFALAVELKEVNLSHNILKTVDRSWFGPIVMNLKELALDTNQLKSVPDGIFDRLTSLQK 365 Query: 111 LILINN 116 + L N Sbjct: 366 IWLHTN 371 >4R08-A nrPDB Length = 811 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 73/278 (26%), Positives = 125/278 (44%), Gaps = 37/278 (13%) Query: 65 VVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINN-------- 116 + +CS+ L++VP+ + LDL +N IT I + F+ L+NL + L +N Sbjct: 24 IAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNG 83 Query: 117 ------KISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSV 170 I+ GAF L L L L NQL ++P +P++L EL + +N I + K Sbjct: 84 NPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEG 143 Query: 171 FNGLNQMIVVELGTNPL-----KSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLT 225 + L + + L N + + IE+G F+ + L + ++ +++ +P LP SL Sbjct: 144 ISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLR 203 Query: 226 ELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISA-----------------VDNGSLAN 268 +L L +I + KGL NL L LS N +D + N Sbjct: 204 KLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQN 263 Query: 269 TPHLRELHLNNNKLVKVPGGLA-DHKYIQVVYLHNNNI 305 LR L+L++ L K+ + +++V+ L N + Sbjct: 264 LTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYL 301 Score = 117 bits (292), Expect = 9e-27, Method: Composition-based stats. Identities = 73/289 (25%), Positives = 113/289 (39%), Gaps = 37/289 (12%) Query: 62 HLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKI--- 118 +LR + D L ++P LP L L N I I L NL L L N Sbjct: 104 NLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNK 163 Query: 119 ----SKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGL 174 + I G F L LE L LS N L +P K+P +L++L + +I + + F GL Sbjct: 164 VCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGL 223 Query: 175 NQMIVVELGTNPLK---------------SSGIENGAFQGMKKLSYIRIADTNITTIPQG 219 + +++L N + S I+ AFQ + +L Y+ ++ T++ I Sbjct: 224 INLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAA 283 Query: 220 LP---PSLTELHLDGNKIT-KVDAASLKG-LNNLAKLGLSFNSISAV------DNGSLAN 268 P L L L+ N + ++ + + L L L LSFN I + + + Sbjct: 284 WFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSK 343 Query: 269 TPHLRELHLNNNKLVKV----PGGLADHKYIQVVYLHNNNISAIGSNDF 313 LR LHL ++ L + + L N I I F Sbjct: 344 LLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLF 392 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 112/275 (40%), Gaps = 24/275 (8%) Query: 82 PDTALLDLQNN-KITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKN 140 PD A L+L N + +F + ++ L L NN++ + A L LE L LS N Sbjct: 483 PDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 542 Query: 141 ----QLKELPEKM-----PKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSG 191 ++ + + L+ L + N I + ++ + N L Sbjct: 543 SHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILW 602 Query: 192 IEN-----GAFQGMKKLSYIRIADTNITTIPQ----GLPPSLTELHLDGNKITKVDAASL 242 ++ F+G+K L+ + ++ + IP LP SLTELH++ N + + L Sbjct: 603 NDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLL 662 Query: 243 KGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGG-LADHKYIQVVYLH 301 + L L L N + + + T LR L L++N++ +P G L++ ++ + L Sbjct: 663 QQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLS 722 Query: 302 NNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQ 336 +N + I + S + L NP + Sbjct: 723 SNLLKTINKSALETK----TTTKLSMLELHGNPFE 753 Score = 87.5 bits (215), Expect = 9e-18, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 108/308 (35%), Gaps = 52/308 (16%) Query: 75 KVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKIS--------------- 119 VP LP L L N +I I + DFK L NL L L N Sbjct: 193 HVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGA 252 Query: 120 --KISPGAFAPLVKLERLYLSKNQLKELPEKMPKT---LQELRVHENEITKVRKSV--FN 172 I AF L +L L LS L+++ K L+ L + N + S Sbjct: 253 SINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLT 312 Query: 173 GLNQMIVVELGTNPLKSSGIE----NGAFQGMKKLSYIRIADTNITTI------PQGLPP 222 L ++ +++L N +K S + + F + L + + + P P Sbjct: 313 MLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLP 372 Query: 223 SLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLN---- 278 +L+ ++L N I ++D + +NL + LS N IS + + + + + Sbjct: 373 NLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKR 432 Query: 279 ---------NNKLVKVPGGL---ADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYS 326 ++ L Y + + L N+I IG N F N + Sbjct: 433 RSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQF----ENLPDIACL 488 Query: 327 GVSLFSNP 334 +S SN Sbjct: 489 NLSANSNA 496 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 73/350 (20%), Positives = 123/350 (35%), Gaps = 65/350 (18%) Query: 18 PFQQKGLFDFMLEDEASGIGPEEHFPEVPEIE--PMGPVCPFRCQCHLRVVQCSDLGLEK 75 P L L + EE F + + + CP V C Sbjct: 196 PKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASIN 255 Query: 76 VPKDLPPDTA---LLDLQNNKITEIKDGDFKNLKNLHTLILINNKISK-ISPGAFAP-LV 130 + + + L+L + + +I FKN+ +L L L N + I+ GAF L Sbjct: 256 IDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLP 315 Query: 131 KLERLYLSKNQLK-------ELPEKMPK--TLQELRVHENEITKVRKSVFNGL---NQMI 178 +LE L LS N +K + K +L+ L + ++R+ F L + Sbjct: 316 RLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLS 375 Query: 179 VVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPS--------------- 223 + LG N +K I+ FQ L I +++ I+ + + S Sbjct: 376 TINLGINFIKQ--IDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRR 433 Query: 224 ---------------------------LTELHLDGNKITKVDAASLKGLNNLAKLGLSFN 256 L L N I + + L ++A L LS N Sbjct: 434 STDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSAN 493 Query: 257 SISAVDNGS-LANTPHLRELHLNNNKLV-KVPGGLADHKYIQVVYLHNNN 304 S + V +G+ + PH++ L L NN+L L + ++V+ L N+ Sbjct: 494 SNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNS 543 Score = 72.4 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 29/137 (21%), Positives = 58/137 (42%), Gaps = 4/137 (2%) Query: 83 DTALLDLQNNKITEIKDGDFKNLK-NLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 + LDL N++ I + F NL +L L + +N + + +LE L L N+ Sbjct: 618 NLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNK 677 Query: 142 LKELPEKM---PKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQ 198 L L + + +L+ L + N I+ + + ++ + ++L +N LK+ + Sbjct: 678 LLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETK 737 Query: 199 GMKKLSYIRIADTNITT 215 KLS + + Sbjct: 738 TTTKLSMLELHGNPFEC 754 Score = 64.3 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 30/141 (21%), Positives = 55/141 (39%), Gaps = 9/141 (6%) Query: 57 FRCQCHLRVVQCSDLGLEKVPKD----LPPDTALLDLQNNKITEIKDGDFKNLKNLHTLI 112 F+ +L + S L+ +P + LP L + +N + + L L Sbjct: 613 FKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLD 672 Query: 113 LINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMP---KTLQELRVHENEITKVRKS 169 L NK+ ++ L L LS N++ LP +L+ L + N + + KS Sbjct: 673 LRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKS 732 Query: 170 VFN--GLNQMIVVELGTNPLK 188 ++ ++EL NP + Sbjct: 733 ALETKTTTKLSMLELHGNPFE 753 Score = 52.0 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 28/89 (31%), Positives = 43/89 (48%), Gaps = 5/89 (5%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 P LLDL+ NK+ + D +L TL+L +N+IS + G + + L+ L LS N Sbjct: 666 PRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNL 725 Query: 142 LKELPEKMPKT-----LQELRVHENEITK 165 LK + + +T L L +H N Sbjct: 726 LKTINKSALETKTTTKLSMLELHGNPFEC 754 >5Y3K-A nrPDB Length = 802 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 70/292 (23%), Positives = 114/292 (39%), Gaps = 41/292 (14%) Query: 53 PVCPFRCQCHLRVVQCSDLGLEKVPKDLPP----DTALLDLQNNKITEIKDGDFKNLKNL 108 P P Q H +V C+ L L+ VP + L L +N+I + D DF L NL Sbjct: 10 PFLPCELQPH-GLVNCNWLFLKSVPHFSAAAPRDNVTSLSLLSNRIHHLHDSDFAQLSNL 68 Query: 109 HTLILINNKIS------------KISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQEL 156 L L N I P F + LE L LS N + +P +P +L L Sbjct: 69 QKLNLKWNCPPAGLSPMHFPCHMTIEPNTFLAVPTLEELNLSYNGITTVP-ALPSSLVSL 127 Query: 157 RVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSG------IENGAFQGMKKLSYIRIAD 210 + I ++ + GL+ + + + N + + GA G+ L+++ + Sbjct: 128 ILSRTNILQLDPTSLTGLHALRFLYMDGNCYYKNPCGRALEVAPGALLGLGNLTHLSLKY 187 Query: 211 TNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFN-------------- 256 N+TT+P+ LPPSL L L N I + L L L L + N Sbjct: 188 NNLTTVPRSLPPSLEYLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCVEC 247 Query: 257 --SISAVDNGSLANTPHLRELHLNNNKLVKV-PGGLADHKYIQVVYLHNNNI 305 + + + ++ L L L ++ L ++ P + V+ L N + Sbjct: 248 PHKFPQLHSDTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFL 299 Score = 124 bits (310), Expect = 8e-29, Method: Composition-based stats. Identities = 67/275 (24%), Positives = 112/275 (40%), Gaps = 29/275 (10%) Query: 82 PDTALLDLQNNKITEIKDGD-FKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKN 140 L L +N I++ +G F L +L L L +NK+ +F L +LE L LS N Sbjct: 475 SRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYN 534 Query: 141 -----------QLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKS 189 L + + TL+ L + N I + ++ N L Sbjct: 535 SQPFSMRGVGHNLSFVAQ--LPTLRYLSLAHNGIHSRVSQQLCS-TSLWALDFSGNSLSQ 591 Query: 190 SGIENGA----FQGMKKLSYIRIADTNITTIPQ----GLPPSLTELHLDGNKITKVDAAS 241 E FQG++ L + ++ + T+ LP SL L L N + + +S Sbjct: 592 MWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQLLRLRNNYLAFFNWSS 651 Query: 242 LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLV-KVPGGLADHKYIQVVYL 300 L L NL L L+ N + A+ NGSL + L+ L ++ N ++ VPG A ++ + L Sbjct: 652 LTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDVSRNSIIFVVPGFFALATRLRELNL 711 Query: 301 HNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPV 335 N + + + F S + + +NP+ Sbjct: 712 SANALRTVEPSWF-----GFLAGSLEVLDVSANPL 741 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 67/279 (24%), Positives = 106/279 (37%), Gaps = 28/279 (10%) Query: 86 LLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGA-FAPLVKLERLYLSKNQL-- 142 LDL N + ++ F L L L L +N IS+ G+ F PL L+ L LS N+L Sbjct: 455 TLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSHNKLDL 514 Query: 143 -KELPEKMPKTLQELRVHENEITKVRKSV------FNGLNQMIVVELGTNPLKSSGIENG 195 L+ L + N + V L + + L N + S + Sbjct: 515 YHGRSFTELPRLEALDLSYNSQPFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQL 574 Query: 196 AFQGM-------KKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNN- 247 + LS + QGL SL L L N++ + +L L Sbjct: 575 CSTSLWALDFSGNSLSQMWAEGDLYLRFFQGLR-SLIRLDLSQNRLHTLLPCTLGNLPKS 633 Query: 248 LAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVP-GGLADHKYIQVVYLHNNNIS 306 L L L N ++ + SL P+L L L N+L + G L +Q + + N+I Sbjct: 634 LQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDVSRNSI- 692 Query: 307 AIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPSTF 345 F PG+ ++L +N ++ ++PS F Sbjct: 693 -----IFVVPGFFALATRLRELNLSANALR--TVEPSWF 724 Score = 99.8 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 112/312 (35%), Gaps = 47/312 (15%) Query: 62 HLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKI 121 +L + L VP+ LPP L L N I + D NL L L + N Sbjct: 179 NLTHLSLKYNNLTTVPRSLPPSLEYLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCD 238 Query: 122 S--------PGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNG 173 P F L +LS+ L+ L + ++ + ++ F G Sbjct: 239 HARNPCVECPHKFPQLHSDTFSHLSR-------------LEGLVLKDSSLYQLNPRWFRG 285 Query: 174 LNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADT--------NITTIPQ-GLPPSL 224 L + V++L N L + AFQG+ +L + ++ ++T P G SL Sbjct: 286 LGNLTVLDLSENFLYDCITKTKAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSL 345 Query: 225 TELHLDGNKITKVDAASLKGLNN---LAKLGLSFNSISAVDNGSLANTPHLRELHLNNNK 281 EL + G + +L+ L L +L L N I+ G + P LR + L++N+ Sbjct: 346 QELDMHGIFFRSLSQKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNR 405 Query: 282 LVKVPGGLADHKY--------IQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSN 333 + +A + L + S DF P N + L N Sbjct: 406 ISGAVEPVATTGEVDGGKKVWLTSRDLTPGPLDTPSSEDFMPSCKNLSFT----LDLSRN 461 Query: 334 PVQYWEIQPSTF 345 + +QP F Sbjct: 462 NL--VTVQPEMF 471 Score = 94.4 bits (233), Expect = 8e-20, Method: Composition-based stats. Identities = 55/248 (22%), Positives = 90/248 (36%), Gaps = 26/248 (10%) Query: 83 DTALLDLQNNKITEIKDGD--FKNLKNLHTLILINNKISKIS------PGAFAPLVKLER 134 + +LDL N + + F+ L L L L N K+S +F L+ L+ Sbjct: 288 NLTVLDLSENFLYDCITKTKAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQE 347 Query: 135 LYLSKNQLKEL------PEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLK 188 L + + L P LQ L + N I + + +F + ++L N + Sbjct: 348 LDMHGIFFRSLSQKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNRIS 407 Query: 189 SSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLT----------ELHLDGNKITKVD 238 + + + + ++T P P S L L N + V Sbjct: 408 GAVEPVATTGEVDGGKKVWLTSRDLTPGPLDTPSSEDFMPSCKNLSFTLDLSRNNLVTVQ 467 Query: 239 AASLKGLNNLAKLGLSFNSISAVDNGS-LANTPHLRELHLNNNKLVKVPG-GLADHKYIQ 296 L+ L L LS NSIS NGS L+ L L++NKL G + ++ Sbjct: 468 PEMFAQLSRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLE 527 Query: 297 VVYLHNNN 304 + L N+ Sbjct: 528 ALDLSYNS 535 Score = 89.8 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 49/202 (24%), Positives = 81/202 (40%), Gaps = 17/202 (8%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPG------AFAPLVKLERL 135 P L L +N I + +L L N +S++ F L L RL Sbjct: 554 PTLRYLSLAHNGIHSRVSQQLCS-TSLWALDFSGNSLSQMWAEGDLYLRFFQGLRSLIRL 612 Query: 136 YLSKNQLKELPEK----MPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSG 191 LS+N+L L +PK+LQ LR+ N + S L + ++L N LK+ Sbjct: 613 DLSQNRLHTLLPCTLGNLPKSLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALS 672 Query: 192 IENGAFQGMKKLSYIRIADTNITTIPQG---LPPSLTELHLDGNKITKVDAASLKGLN-N 247 NG+ +L + ++ +I + G L L EL+L N + V+ + L + Sbjct: 673 --NGSLPSGTQLQRLDVSRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGS 730 Query: 248 LAKLGLSFNSISAVDNGSLANT 269 L L +S N + + + Sbjct: 731 LEVLDVSANPLHCACGAAFVDF 752 Score = 65.1 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 33/115 (28%), Positives = 54/115 (46%), Gaps = 4/115 (3%) Query: 78 KDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYL 137 +LP LL L+NN + L NL TL L N++ +S G+ +L+RL + Sbjct: 628 GNLPKSLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDV 687 Query: 138 SKNQLKELPEK---MPKTLQELRVHENEITKVRKSVFNGLN-QMIVVELGTNPLK 188 S+N + + + L+EL + N + V S F L + V+++ NPL Sbjct: 688 SRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDVSANPLH 742 Score = 57.4 bits (137), Expect = 9e-09, Method: Composition-based stats. Identities = 26/100 (26%), Positives = 42/100 (42%), Gaps = 4/100 (4%) Query: 79 DLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLS 138 L P+ LDL N++ + +G + L L + N I + PG FA +L L LS Sbjct: 653 TLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDVSRNSIIFVVPGFFALATRLRELNLS 712 Query: 139 KNQLKELPEK----MPKTLQELRVHENEITKVRKSVFNGL 174 N L+ + + +L+ L V N + + F Sbjct: 713 ANALRTVEPSWFGFLAGSLEVLDVSANPLHCACGAAFVDF 752 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 20/111 (18%), Positives = 40/111 (36%), Gaps = 11/111 (9%) Query: 222 PSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNK 281 ++T L L N+I + + L+NL KL L +N L+ + + N Sbjct: 42 DNVTSLSLLSNRIHHLHDSDFAQLSNLQKLNLKWNC----PPAGLSPMHFPCHMTIEPNT 97 Query: 282 LVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFS 332 + VP ++ + L N I+ + + + + + S Sbjct: 98 FLAVPT-------LEELNLSYNGITTVPALPSSLVSLILSRTNILQLDPTS 141 >6O00-A nrPDB Length = 820 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 75/321 (23%), Positives = 138/321 (42%), Gaps = 50/321 (15%) Query: 73 LEKVPKDLPPDTALLDLQNNKITEIK----DGDFKNLKNLHTLILINNKISKISPGAFAP 128 L +P + L++L+ K+ I L L L L + +KI A A Sbjct: 435 LSGIPDTVF---DLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA-AKIEAPALAF 490 Query: 129 LV-KLERLYLSKNQLKELPEKMP--KTLQELRVHEN-EITKVRKSVFNGLNQMI---VVE 181 L L L++ +KE+P + KTL+EL + N R V +GL ++ V+ Sbjct: 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLR 550 Query: 182 LGTN-------------PLKSSGIEN--------GAFQGMKKLSYIRIADTNITTIPQGL 220 L +N L+ I N + + M L+ + + ++ IP + Sbjct: 551 LKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSI 610 Query: 221 PP--SLTELHLDGNKITKVDAA-SLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHL 277 +L E+ L N + ++ S + L+ L L L +N I+ + + N +L L+L Sbjct: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIP-IQIGNLTNLERLYL 669 Query: 278 NNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQY 337 N NK+ K+P L + ++ + L +NN++ F P + + +++ +N ++ Sbjct: 670 NRNKIEKIPTQLFYCRKLRYLDLSHNNLT------FLPADIGLLQ-NLQNLAVTANRIE- 721 Query: 338 WEIQPSTFRCVYVRAAVQLGN 358 + P F+C +R A+ LGN Sbjct: 722 -ALPPELFQCRKLR-ALHLGN 740 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 51/231 (22%), Positives = 93/231 (40%), Gaps = 13/231 (5%) Query: 72 GLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVK 131 L +V D+ L + N I K + NL L LI + +I P + L Sbjct: 557 KLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERI-PHSIFSLHN 615 Query: 132 LERLYLSKNQLKEL----PEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPL 187 L+ + L N LK + + L L++ N I + L + + L N + Sbjct: 616 LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIP-IQIGNLTNLERLYLNRNKI 674 Query: 188 KSSGIENGAFQGMKKLSYIRIADTNITTIPQ--GLPPSLTELHLDGNKITKVDAASLKGL 245 + I F +KL Y+ ++ N+T +P GL +L L + N+I + + Sbjct: 675 EK--IPTQLFY-CRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQ-C 730 Query: 246 NNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQ 296 L L L N + ++ + + +L ++ L N+L +P L + ++ Sbjct: 731 RKLRALHLGNNVLQSLPSR-VGELTNLTQIELRGNRLECLPVELGECPLLK 780 >5ZSN-B nrPDB Length = 823 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 81/270 (30%), Positives = 123/270 (45%), Gaps = 28/270 (10%) Query: 65 VVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKIS----- 119 +V C+D L ++P +P +T L L N I +I F L +L + N + Sbjct: 26 IVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLVHLVEIDFRCNCVPIRLGS 85 Query: 120 ---------KISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSV 170 +I P +F+ L L+ LYL NQL E+P+ +P +LQ L + N I +RK Sbjct: 86 KSNMCPRRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQ 145 Query: 171 FNGLNQMIVVELGTNPLK------SSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSL 224 L + ++ LG N S IE AF + KL + + D N+TT+P LP +L Sbjct: 146 LTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLPSTL 205 Query: 225 TELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVK 284 TEL+L N I ++ LN L L LS N N TP NN ++ Sbjct: 206 TELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCY-NAPFPCTP------CKNNSPLQ 258 Query: 285 VPGGLAD-HKYIQVVYLHNNNISAIGSNDF 313 +P D ++V+ LH+N++ + F Sbjct: 259 IPVNAFDALTELKVLRLHSNSLQHVPPRWF 288 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 71/295 (24%), Positives = 120/295 (40%), Gaps = 38/295 (12%) Query: 57 FRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINN 116 F +L+ + L ++P+ LPP LL L+ N I I+ L N+ L L N Sbjct: 101 FSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQLTELANIEILYLGQN 160 Query: 117 KI--------SKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRK 168 I AF L KL+ L L N + +P +P TL EL ++ N I ++++ Sbjct: 161 CYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLPSTLTELYLYNNMIAEIQE 220 Query: 169 SVFNGLNQMIVVELGTNP---------------LKSSGIENGAFQGMKKLSYIRIADTNI 213 FN LNQ+ +++L N I AF + +L +R+ ++ Sbjct: 221 DDFNNLNQLQILDLSGNCPRCYNAPFPCTPCKNNSPLQIPVNAFDALTELKVLRLHSNSL 280 Query: 214 TTIPQGLP---PSLTELHLDGNKI-TKVDAASLKG-LNNLAKLGLSFN------SISAVD 262 +P +L EL L N + ++ A L NL +L LSFN S Sbjct: 281 QHVPPRWFKNINNLQELDLSQNFLAKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNL 340 Query: 263 NGSLANTPHLRELHLNNNKLVKVP----GGLADHKYIQVVYLHNNNISAIGSNDF 313 + + ++ L+ L + ++ L + + ++V+ L N I + F Sbjct: 341 SQAFSSLKSLKILRIRGYVFKELKSFQLSPLHNLQNLEVLDLGTNFIKIANLSMF 395 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 62/250 (24%), Positives = 103/250 (41%), Gaps = 21/250 (8%) Query: 84 TALLDLQNNKIT-EIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQL 142 L+L N I+ + +F+ L L L NN++ + AF L KLE L +S N Sbjct: 497 LKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELRKLEVLDISSNSH 556 Query: 143 KELPEKMP---------KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSS--- 190 E + K LQ+L +++N+I+ + +E N L Sbjct: 557 YFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMES-ESLRTLEFRGNHLDVLWRD 615 Query: 191 --GIENGAFQGMKKLSYIRIADTNITTIP----QGLPPSLTELHLDGNKITKVDAASLKG 244 F+ + KL + I+ +++ +P G+PP+L L L N + L+ Sbjct: 616 GDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRY 675 Query: 245 LNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVP-GGLADHKYIQVVYLHNN 303 L NL L LS N ++ V + L+ L L NN++ + L D ++ + L +N Sbjct: 676 LKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSN 735 Query: 304 NISAIGSNDF 313 I I F Sbjct: 736 KIQMIQKTSF 745 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 91/378 (24%), Positives = 136/378 (35%), Gaps = 76/378 (20%) Query: 39 EEHFPEVPEIE--PMGPVCPFRCQCH---------------LRVVQCSDLGLEKVPKDLP 81 +E E+ IE +G C +R C+ L+V+ D + VP LP Sbjct: 143 KEQLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLP 202 Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKIS-----------------KISPG 124 L L NN I EI++ DF NL L L L N +I Sbjct: 203 STLTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPCKNNSPLQIPVN 262 Query: 125 AFAPLVKLERLYLSKNQLKELPEKMPK---TLQELRVHENEITKVRKSV--FNGLNQMIV 179 AF L +L+ L L N L+ +P + K LQEL + +N + K + L +I Sbjct: 263 AFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFLAKEIGDAKFLHFLPNLIQ 322 Query: 180 VELGTN----PLKSSGIENGAFQGMKKLSYIRIADTNITTI------PQGLPPSLTELHL 229 ++L N ++S + AF +K L +RI + P +L L L Sbjct: 323 LDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFQLSPLHNLQNLEVLDL 382 Query: 230 DGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH-------------LREL- 275 N I + + K L + LS N IS + + L +L Sbjct: 383 GTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSLVPRGSSNARTSVESYEPQVLEQLY 442 Query: 276 ------HLNNNKLVKVPGGLADH-----KYIQVVYLHNNNISAIGSNDFCPPGYNTKKAS 324 + + + KY Q + L N+I I S+DF K + Sbjct: 443 YFRYDKYARSCRFKNKEASFTSVQESCYKYGQTLDLSKNSIFFIKSSDF-QHLSFLKCLN 501 Query: 325 YSGVSLFSNPVQYWEIQP 342 SG +L S + E QP Sbjct: 502 LSG-NLISQTLNGSEFQP 518 Score = 54.3 bits (129), Expect = 7e-08, Method: Composition-based stats. Identities = 31/146 (21%), Positives = 58/146 (39%), Gaps = 7/146 (4%) Query: 83 DTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQL 142 + LDL +N++T + + ++L LIL NN+I ++ +L L LS N++ Sbjct: 678 NLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKI 737 Query: 143 -----KELPEKMPKTLQELRVHENEITKV-RKSVFNGLNQMIVVELGTNPLKSSGIENGA 196 PE + L+ L +H N F Q V + + + GA Sbjct: 738 QMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVQHTEVTIPYLATDVTCVGPGA 797 Query: 197 FQGMKKLSYIRIADTNITTIPQGLPP 222 +G + + + + + + L P Sbjct: 798 HKG-QSVISLDLYTCELDLTNEFLVP 822 >3WPI-A nrPDB Length = 803 Score = 167 bits (422), Expect = 7e-42, Method: Composition-based stats. Identities = 71/314 (22%), Positives = 122/314 (38%), Gaps = 44/314 (14%) Query: 56 PFRCQCHLR---VVQCSDLGLEKVPKDLPP----DTALLDLQNNKITEIKDGDFKNLKNL 108 P C L+ +V C+ L L+ VP+ + L L +N+I + + DF +L NL Sbjct: 9 PAFLPCELKPHGLVDCNWLFLKSVPRFSAAASCSNITRLSLISNRIHHLHNSDFVHLSNL 68 Query: 109 HTLILINNKISK------------ISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQEL 156 L L N I P F + LE L LS N + +P ++P +L L Sbjct: 69 RQLNLKWNCPPTGLSPLHFSCHMTIEPRTFLAMRTLEELNLSYNGITTVP-RLPSSLVNL 127 Query: 157 RVHENEITKVRKSVFNGLNQMIVVELGTNPLKSS------GIENGAFQGMKKLSYIRIAD 210 + I + + GL + V+ + N + + GA G+ +L+++ + Sbjct: 128 SLSHTNILVLDANSLAGLYSLRVLFMDGNCYYKNPCTGAVKVTPGALLGLSQLTHLSLKY 187 Query: 211 TNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISA---------- 260 N+T +P+ LPPSL L + N I K+ L L +L L + N Sbjct: 188 NNLTKVPRQLPPSLEYLLVSYNLIVKLGPEDLAQLTSLRVLDVGGNCRRCDHAPNPCIEC 247 Query: 261 ------VDNGSLANTPHLRELHLNNNKLVKVPGGLAD-HKYIQVVYLHNNNI-SAIGSND 312 + + + HL L L ++ L + + V+ L N + +I + Sbjct: 248 GQKSLHLHPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVQLSVLDLSENFLYESITHTN 307 Query: 313 FCPPGYNTKKASYS 326 +K + S Sbjct: 308 AFQNLTRLRKLNLS 321 Score = 99.0 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 65/289 (22%), Positives = 114/289 (39%), Gaps = 23/289 (7%) Query: 49 EPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLP---PDTALLDLQNNKI-TEIKDGDFKN 104 P RC+ + S L + ++ L L +N I + F Sbjct: 440 TPASKNFMDRCKNFKFTMDLSRNNLVTIKPEMFVQLSRLQCLSLSHNSIAQAVNGSQFLP 499 Query: 105 LKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ----LKELPEKM-----PKTLQE 155 L NL L L +NK+ +F+ L +L+ L LS N +K + + LQ Sbjct: 500 LTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHQFSFVTHLSMLQS 559 Query: 156 LRVHENEITKVRKSVFNGLNQMIVVELGTNPL----KSSGIENGAFQGMKKLSYIRIADT 211 L + N+I S N N + ++ N + G+ FQG+ L + ++ Sbjct: 560 LSLAHNDIHTRVSSHLNS-NSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQN 618 Query: 212 NITTIPQGLPPSLTELHLD----GNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLA 267 N+ + +L + N ++ + SL L NL L L+ N + A+ G+L Sbjct: 619 NLHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTQGTLP 678 Query: 268 NTPHLRELH-LNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCP 315 N L++L +N+ + VP A ++ V L +N + + + F P Sbjct: 679 NGTLLQKLDVSSNSIVSVVPAFFALAVELKEVNLSHNILKTVDRSWFGP 727 Score = 98.6 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 112/301 (37%), Gaps = 28/301 (9%) Query: 63 LRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKIS-KI 121 L + L KVP+ LPP L + N I ++ D L +L L + N Sbjct: 180 LTHLSLKYNNLTKVPRQLPPSLEYLLVSYNLIVKLGPEDLAQLTSLRVLDVGGNCRRCDH 239 Query: 122 SPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVE 181 +P + + L+L L L+ L + ++ + + S F GL Q+ V++ Sbjct: 240 APNPCIECGQ-KSLHLHPETFHHLSH-----LEGLVLKDSSLHTLNSSWFQGLVQLSVLD 293 Query: 182 LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAAS 241 L N L S AFQ + +L + ++ + S LHL A+S Sbjct: 294 LSENFLYESITHTNAFQNLTRLRKLNLSFNYRKKV------SFARLHL---------ASS 338 Query: 242 LKGLNNLAKLGLSF---NSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLA-DHKYIQV 297 K L +L +L ++ ++ LA+ P L LHL N + + + + ++ Sbjct: 339 FKNLVSLQELNMNGIFFRLLNKYTLRWLADLPKLHTLHLQMNFINQAQLSIFGTFRALRF 398 Query: 298 VYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPSTF--RCVYVRAAVQ 355 V L +N IS + P +S +P F RC + + Sbjct: 399 VDLSDNRISGPSTLSEATPEEADDAEQEELLSADPHPAPLSTPASKNFMDRCKNFKFTMD 458 Query: 356 L 356 L Sbjct: 459 L 459 >5LFN-A nrPDB Length = 337 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 76/283 (26%), Positives = 124/283 (43%), Gaps = 37/283 (13%) Query: 55 CPFRCQCH--LRVVQCSDLGLEKVPKDLPPDTALLDLQNN-------------------- 92 CP C CH L+ V C +GL+K+PK + T LL+LQ N Sbjct: 1 CPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLH 59 Query: 93 ----KITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEK 148 +I E+ G F+ LK L L L +N I + GAF L +L LYL N++ ELP Sbjct: 60 LQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRG 119 Query: 149 MPK---TLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSY 205 + L L+++ N+I ++R F G + + L N L S ++ GA ++ L+ Sbjct: 120 LLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENAL--SSLQPGALDDVENLAK 177 Query: 206 IRIADTNITTIPQGLPPSL---TELHLDGNKITKVDAASLKGLNN-LAKLGLSFNSISAV 261 + +++ P L EL L N + + + + L L L ++ Sbjct: 178 FHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKF 237 Query: 262 DNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNN 304 +G+ L+ +HL NN+L ++P ++ + L NN Sbjct: 238 SDGAFLGVTTLKHVHLENNRLNQLPSNFP-FDSLETLALTNNP 279 >3CIG-A nrPDB Length = 697 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 72/303 (23%), Positives = 117/303 (38%), Gaps = 60/303 (19%) Query: 58 RCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNK 117 +C V CS L L +P DLP + +L+L +N++ + +F L L N Sbjct: 1 QCTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNS 60 Query: 118 ISKISPGAFAPLVKLERLYLSKNQLKELPEK---MPKTLQELRVHENEITKVRKSVFNGL 174 ISK+ P L L+ L L N+L ++ ++ L EL + N I K++ + F Sbjct: 61 ISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQ 120 Query: 175 NQMIVVELGTNPLKSSGIENGA------------------------FQGMKKLSYIRIAD 210 +I ++L N L S+ + G F G L + ++ Sbjct: 121 KNLIKLDLSHNGLSSTKLGTGVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSS 180 Query: 211 TNITTIPQG-----------------LPPSLTE-------------LHLDGNKITKVDAA 240 + G L P LTE L L N++ + Sbjct: 181 NPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSES 240 Query: 241 SLKGL--NNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKV-PGGLADHKYIQV 297 + GL NL +L LS+N++ V NGS + P LR L L N + ++ P ++ Sbjct: 241 TFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRY 300 Query: 298 VYL 300 + L Sbjct: 301 LSL 303 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 62/251 (24%), Positives = 102/251 (40%), Gaps = 21/251 (8%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYL---- 137 + LDL N + ++ +G F L +L L L N I ++SP +F L L L L Sbjct: 248 TNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAF 307 Query: 138 --------SKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKS 189 S + + + K L+ L + +N I + + F GL + + L Sbjct: 308 TKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLSKTFTSL 367 Query: 190 SGIENGAFQGMKK--LSYIRIADTNITTIPQGLPP---SLTELHLDGNKI-TKVDAASLK 243 + N F + L + + +I+ I G L L L N+I K+ + Sbjct: 368 QTLTNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWR 427 Query: 244 GLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKV---PGGLADHKYIQVVYL 300 GL N+ ++ LS+N + S A P L+ L L L V P + + ++ L Sbjct: 428 GLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDL 487 Query: 301 HNNNISAIGSN 311 NNNI+ I + Sbjct: 488 SNNNIANINED 498 Score = 88.2 bits (217), Expect = 5e-18, Method: Composition-based stats. Identities = 61/296 (20%), Positives = 113/296 (38%), Gaps = 25/296 (8%) Query: 86 LLDLQNNKITEIKDGDFKNLKNLHTLILINNKI-SKISPGAFAPLVKLERLYLSKN---Q 141 L+L N I++I +G F L L L L N+I K+S + L + +YLS N Q Sbjct: 385 TLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQ 444 Query: 142 LKELPEKMPKTLQELRVHENEITKVR--KSVFNGLNQMIVVELGTNPLKSSGIENGAFQG 199 L + +LQ L + + V S F L + +++L N + + I +G Sbjct: 445 LSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNI--ANINEDLLEG 502 Query: 200 MKKLSYIRIADTNITTIPQGLPPS-----------LTELHLDGNKITKVDAASLKGLNNL 248 ++ L + N+ + + P L L+L+ N + ++ K L L Sbjct: 503 LENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGLDEIPVGVFKNLFEL 562 Query: 249 AKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLA--DHKYIQVVYLHNNNIS 306 + L N+++ ++ + LR L+L N + V + + + + + N Sbjct: 563 KSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDVFGPPFQNLNSLDMRFNPFD 622 Query: 307 -AIGSNDFCPPGYNTKKASYSGVS---LFSNPVQYWEIQPSTFRCVYVRAAVQLGN 358 S + N + S +S L + P Y+ F + + N Sbjct: 623 CTCESISWFVNWINQTHTNISELSTHYLCNTPHHYYGFPLKLFDTSSCKDSAPFEN 678 Score = 76.7 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 57/267 (21%), Positives = 101/267 (37%), Gaps = 21/267 (7%) Query: 56 PFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILIN 115 L ++ S ++ P + LDL +N ++ K G L+NL L+L Sbjct: 95 FCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQELLLAK 154 Query: 116 NKISKI--SPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNG 173 NKI + F L +L LS N LKE +T+ +L ++ + Sbjct: 155 NKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEK 214 Query: 174 L------NQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQG---LPPSL 224 L + + L N L ++ + L+ + ++ N+ + G PSL Sbjct: 215 LCWELSNTSIQNLSLANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSL 274 Query: 225 TELHLDGNKITKVDAASLKGLNNLAKLGL---------SFNSISAVDNGSLANTPHLREL 275 L L+ N I ++ S GL+NL L L S S +D+ S +L L Sbjct: 275 RYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYL 334 Query: 276 HLNNNKLVKVPGG-LADHKYIQVVYLH 301 ++++N + ++ + L Sbjct: 335 NMDDNNIPSTKSNTFTGLVSLKYLSLS 361 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 38/192 (19%), Positives = 75/192 (39%), Gaps = 14/192 (7%) Query: 63 LRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKI- 121 LR V ++ + P + +LDL NN I I + + L+NL L +N ++++ Sbjct: 461 LRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLLEGLENLEILDFQHNNLARLW 520 Query: 122 -------SPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQEL---RVHENEITKVRKSVF 171 L L L L N L E+P + K L EL + N + K+ +F Sbjct: 521 KRANPGGPVNFLKGLSHLHILNLESNGLDEIPVGVFKNLFELKSINLGLNNLNKLEPFIF 580 Query: 172 NGLNQMIVVELGTNPLKSSGIENGAFQGM-KKLSYIRIADTNITTIPQGLPPSLTELHLD 230 + + + L N + + +E F + L+ + + + + + ++ Sbjct: 581 DDQTSLRSLNLQKNLI--TSVEKDVFGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQT 638 Query: 231 GNKITKVDAASL 242 I+++ L Sbjct: 639 HTNISELSTHYL 650 Score = 47.8 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 28/134 (20%), Positives = 51/134 (38%), Gaps = 29/134 (21%) Query: 209 ADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLAN 268 + +T IP LP ++T L+L N++ ++ + + LA L FNSIS ++ Sbjct: 12 SHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQI 71 Query: 269 TPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGV 328 P ++V+ L +N +S I F + + + Sbjct: 72 LP-----------------------LLKVLNLQHNELSQISDQTF------VFCTNLTEL 102 Query: 329 SLFSNPVQYWEIQP 342 L SN + + P Sbjct: 103 DLMSNSIHKIKSNP 116 >6GFF-I nrPDB Length = 618 Score = 160 bits (405), Expect = 7e-40, Method: Composition-based stats. Identities = 77/262 (29%), Positives = 118/262 (45%), Gaps = 37/262 (14%) Query: 59 CQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKI 118 C+ + V C LGL +VP LPPDT LDL N++ I L L L N+I Sbjct: 7 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 66 Query: 119 SKISPGAFAPLVKLERLYLSKNQL----------------------------KELPEKMP 150 S + PGAF L LE L L+ N+L L E++ Sbjct: 67 SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 126 Query: 151 ---KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIR 207 +L L + EN +T++ + F + + ++L +N L IE+GAF+G+ +L+++ Sbjct: 127 GEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMD--IEDGAFEGLPRLTHLN 184 Query: 208 IADTNITTIPQGLPPSLTELHLDGNKITKVDAAS-LKGLNNLAKLGLSFNSISAVDNGSL 266 ++ ++T I L L L N I AS + L L L N + + L Sbjct: 185 LSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--L 242 Query: 267 ANTPHLRELHLNNNKLVKVPGG 288 A P L L+L+NN L+++P G Sbjct: 243 AALPRLIYLNLSNN-LIRLPTG 263 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 65/285 (22%), Positives = 109/285 (38%), Gaps = 42/285 (14%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 P L L N +T + F+++ L L L +N + I GAF L +L L LS+N Sbjct: 130 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNS 189 Query: 142 LKELPEKMPKTLQELRVHENEITKVR-KSVFNGLNQMIVVELGTNPLKSSGIENGAFQGM 200 L + + + L+ L + N I + S Q+ ++L N L + + Sbjct: 190 LTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL----LHFPDLAAL 245 Query: 201 KKLSYIRIADTNITTIPQGLP------------------------------PSLTELHLD 230 +L Y+ ++ N+ +P G P L L L Sbjct: 246 PRLIYLNLS-NNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLS 304 Query: 231 GNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLA 290 N+I + + L+ L +L L LS N + + L + P L L L++N L + G Sbjct: 305 YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGAR 364 Query: 291 DHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPV 335 ++ + L N + + PP AS ++L N V Sbjct: 365 ALGSLRTLLLQGNALRDL------PPYTFANLASLQRLNLQGNRV 403 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 60/298 (20%), Positives = 112/298 (37%), Gaps = 33/298 (11%) Query: 57 FRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLK-NLHTLILIN 115 F L + S L + +LDL N I + + L L L Sbjct: 174 FEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRE 233 Query: 116 NKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNG-- 173 NK+ + A L +L L LS N L LP P+ + + + + S +G Sbjct: 234 NKL--LHFPDLAALPRLIYLNLSNN-LIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNA 290 Query: 174 ----LNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQ---GLPPSLTE 226 L+Q++ ++L N ++ I + + + L ++ ++ + T G P L Sbjct: 291 SGRPLSQLLNLDLSYNEIEL--IPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLML 348 Query: 227 LHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVP 286 L L N + ++ + + L +L L L N++ + + AN L+ L+L N++ Sbjct: 349 LDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCG 407 Query: 287 GG----------LADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNP 334 G + ++ + L +N I + + F + + L SNP Sbjct: 408 GPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFL-------HTPLTELDLSSNP 458 Score = 104 bits (258), Expect = 1e-22, Method: Composition-based stats. Identities = 65/269 (24%), Positives = 98/269 (36%), Gaps = 39/269 (14%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 LDL N+I I D ++L +L L L N + L L L LS N Sbjct: 296 SQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNA 355 Query: 142 LK--ELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENG---- 195 L+ EL + +L+ L + N + + F L + + L N + G + Sbjct: 356 LETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPS 415 Query: 196 ---AFQGMKKLSYIRIADTNITTIPQG--LPPSLTELHLDGNKITKVDAASLKGLNN--- 247 AF G+ L + + D I + G L LTEL L N +V +L GL Sbjct: 416 GCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLE 475 Query: 248 ---------------------LAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVP 286 L +L L+ N +S + + A L L L NN +P Sbjct: 476 VLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAV--SLEVLDLRNNSFSLLP 533 Query: 287 GGLADH--KYIQVVYLHNNNISAIGSNDF 313 G ++ +YL N +S G+ Sbjct: 534 GSAMGGLETSLRRLYLQGNPLSCCGNGWL 562 Score = 89.4 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 44/210 (20%), Positives = 89/210 (42%), Gaps = 17/210 (8%) Query: 142 LKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMK 201 L ++P +P + L + N++ + S + ++L TN + S ++ GAFQ + Sbjct: 21 LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI--SFLQPGAFQALT 78 Query: 202 KLSYIRIADTNI---TTIPQG---LPPSLTELHLDGNKITK-VDAASLKGLNNLAKLGLS 254 L ++ +A + T + G P +T L L GN + + L +L L L+ Sbjct: 79 HLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLA 138 Query: 255 FNSISAVDNGSLANTPHLRELHLNNNKLVKVPGG-LADHKYIQVVYLHNNNISAIGSNDF 313 NS++ + + + P L +L L++N L+ + G + + L N+++ Sbjct: 139 ENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLT------- 191 Query: 314 CPPGYNTKKASYSGVSLFSNPVQYWEIQPS 343 C ++ ++ +S S QP Sbjct: 192 CISDFSLQQLRVLDLSCNSIEAFQTASQPQ 221 >5Y3M-A nrPDB Length = 801 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 70/314 (22%), Positives = 115/314 (36%), Gaps = 42/314 (13%) Query: 53 PVCPFRCQCHLRVVQCSDLGLEKVPKDLP----PDTALLDLQNNKITEIKDGDFKNLKNL 108 P Q H + V C+ L L+ VP + L L +N+I + D DF +L NL Sbjct: 10 AFLPCELQPHGQ-VDCNWLFLKSVPHFSAGAPRANVTSLSLISNRIHHLHDSDFVHLSNL 68 Query: 109 HTLILINNKIS------------KISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQEL 156 L L N I P F + LE L LS N + +P + Sbjct: 69 RVLNLKWNCPPAGLSPMHFPCRMTIEPNTFLAVPTLEELNLSYNGITTVPALPSSLVSLS 128 Query: 157 RVHENEITKVRKSVFNGLNQMIVVELGTNPL------KSSGIENGAFQGMKKLSYIRIAD 210 H I + + F GL+ + + + N ++ + GA G+ L+++ + Sbjct: 129 LSHT-SILVLGPTHFTGLHALRFLYMDGNCYYMNPCPRALEVAPGALLGLGNLTHLSLKY 187 Query: 211 TNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFN-------------- 256 N+T +P+ LPPSL L L N I + L L L L + N Sbjct: 188 NNLTEVPRRLPPSLDTLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCREC 247 Query: 257 --SISAVDNGSLANTPHLRELHLNNNKLVKVPGGLA-DHKYIQVVYLHNNNI-SAIGSND 312 + + + ++ L L L ++ L K+ +QV+ L N + I Sbjct: 248 PKNFPKLHPDTFSHLSRLEGLVLKDSSLYKLEKDWFRGLGRLQVLDLSENFLYDYITKTT 307 Query: 313 FCPPGYNTKKASYS 326 ++ + S Sbjct: 308 IFNDLTQLRRLNLS 321 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 65/282 (23%), Positives = 109/282 (38%), Gaps = 34/282 (12%) Query: 86 LLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGA-FAPLVKLERLYLSKNQL-- 142 LDL N + I+ F L L L L +N IS+ G+ F PL L L LS N+L Sbjct: 454 TLDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQAVNGSQFVPLTSLRVLDLSHNKLDL 513 Query: 143 -KELPEKMPKTLQELRVHENE----ITKVRKSV--FNGLNQMIVVELGTNPLKSSGIENG 195 L+ L + N + V ++ L + + L N + S Sbjct: 514 YHGRSFTELPQLEALDLSYNSQPFSMQGVGHNLSFVAQLPSLRYLSLAHNGIHS---RVS 570 Query: 196 AFQGMKKLSYIRIADTNIT----------TIPQGLPPSLTELHLDGNKITKVDAASLKGL 245 L + + +++ +GL +L +L L N + + L L Sbjct: 571 QKLSSASLRALDFSGNSLSQMWAEGDLYLCFFKGLR-NLVQLDLSENHLHTLLPRHLDNL 629 Query: 246 NN-LAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVP-GGLADHKYIQVVYLHNN 303 L +L L N+++ + SL P L L L N+L + G L +Q + + +N Sbjct: 630 PKSLRQLRLRDNNLAFFNWSSLTVLPRLEALDLAGNQLKALSNGSLPPGIRLQKLDVSSN 689 Query: 304 NISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPSTF 345 +I F PG+ + ++L +N ++ + PS F Sbjct: 690 SIG------FVIPGFFVRATRLIELNLSANALK--TVDPSWF 723 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 58/243 (23%), Positives = 94/243 (38%), Gaps = 20/243 (8%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGA------FAPLVKLERL 135 +LDL +NK+ F L L L L N G A L L L Sbjct: 499 TSLRVLDLSHNKLDLYHGRSFTELPQLEALDLSYNSQPFSMQGVGHNLSFVAQLPSLRYL 558 Query: 136 YLSKNQL-KELPEKMPK-TLQELRVHENEITKVRKSV------FNGLNQMIVVELGTNPL 187 L+ N + + +K+ +L+ L N ++++ F GL ++ ++L N L Sbjct: 559 SLAHNGIHSRVSQKLSSASLRALDFSGNSLSQMWAEGDLYLCFFKGLRNLVQLDLSENHL 618 Query: 188 KSSGIENGAFQGMKKLSYIRIADTNITTI---PQGLPPSLTELHLDGNKITKVDAASLKG 244 + + K L +R+ D N+ + P L L L GN++ + SL Sbjct: 619 HTL-LPRHLDNLPKSLRQLRLRDNNLAFFNWSSLTVLPRLEALDLAGNQLKALSNGSLPP 677 Query: 245 LNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLAD--HKYIQVVYLHN 302 L KL +S NSI V G L EL+L+ N L V ++++ + Sbjct: 678 GIRLQKLDVSSNSIGFVIPGFFVRATRLIELNLSANALKTVDPSWFGSLAGTLKILDVSA 737 Query: 303 NNI 305 N + Sbjct: 738 NPL 740 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 55/289 (19%), Positives = 96/289 (33%), Gaps = 57/289 (19%) Query: 82 PDTALLDLQNNKITEIK--------------------DGDFKNLKNLHTLILINN----- 116 P L+L N IT + F L L L + N Sbjct: 102 PTLEELNLSYNGITTVPALPSSLVSLSLSHTSILVLGPTHFTGLHALRFLYMDGNCYYMN 161 Query: 117 ---KISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNG 173 + +++PGA L L L L N L E+P ++P +L L + N I + Sbjct: 162 PCPRALEVAPGALLGLGNLTHLSLKYNNLTEVPRRLPPSLDTLLLSYNHIVTLAPEDLAN 221 Query: 174 LNQMIVVELGTNPLKSS--------------GIENGAFQGMKKLSYIRIADTNITTIPQG 219 L + V+++G N + + F + +L + + D+++ + + Sbjct: 222 LTALRVLDVGGNCRRCDHARNPCRECPKNFPKLHPDTFSHLSRLEGLVLKDSSLYKLEKD 281 Query: 220 LPPSL---TELHLDGNKITKVDAAS--LKGLNNLAKLGLSFNSISAVDNG------SLAN 268 L L L N + + L L +L LSFN V S + Sbjct: 282 WFRGLGRLQVLDLSENFLYDYITKTTIFNDLTQLRRLNLSFNYHKKVSFAHLHLASSFGS 341 Query: 269 TPHLRELHLNNNKLVKVP----GGLADHKYIQVVYLHNNNISAIGSNDF 313 L +L ++ + L +Q ++L N I+ + F Sbjct: 342 LVSLEKLDMHGIFFRSLTNITLQSLTRLPKLQSLHLQLNFINQAQLSIF 390 Score = 98.2 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 60/266 (22%), Positives = 96/266 (36%), Gaps = 56/266 (21%) Query: 62 HLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINN----- 116 +L + L +VP+ LPP L L N I + D NL L L + N Sbjct: 179 NLTHLSLKYNNLTEVPRRLPPSLDTLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCD 238 Query: 117 -----------KISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITK 165 K+ P F+ L +LE L L ++ + K Sbjct: 239 HARNPCRECPKNFPKLHPDTFSHLSRLEGLVLK---------------------DSSLYK 277 Query: 166 VRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLT 225 + K F GL ++ V++L N L + F + +L + ++ + S Sbjct: 278 LEKDWFRGLGRLQVLDLSENFLYDYITKTTIFNDLTQLRRLNLSFNYHKKV------SFA 331 Query: 226 ELHLDGNKITKVDAASLKGLNNLAKLGLSF---NSISAVDNGSLANTPHLRELHLNNNKL 282 LHL A+S L +L KL + S++ + SL P L+ LHL N + Sbjct: 332 HLHL---------ASSFGSLVSLEKLDMHGIFFRSLTNITLQSLTRLPKLQSLHLQLNFI 382 Query: 283 VKVPGGLADH-KYIQVVYLHNNNISA 307 + + + V L +N IS Sbjct: 383 NQAQLSIFGAFPSLLFVDLSDNRISG 408 Score = 93.6 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 57/247 (23%), Positives = 88/247 (35%), Gaps = 25/247 (10%) Query: 83 DTALLDLQNNKITEIKDGD--FKNLKNLHTLILINNKISKISPG------AFAPLVKLER 134 +LDL N + + F +L L L L N K+S +F LV LE+ Sbjct: 288 RLQVLDLSENFLYDYITKTTIFNDLTQLRRLNLSFNYHKKVSFAHLHLASSFGSLVSLEK 347 Query: 135 LYL------SKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLK 188 L + S + LQ L + N I + + S+F ++ V+L N + Sbjct: 348 LDMHGIFFRSLTNITLQSLTRLPKLQSLHLQLNFINQAQLSIFGAFPSLLFVDLSDNRIS 407 Query: 189 SSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLT---------ELHLDGNKITKVDA 239 + A + + + P S L L N + + Sbjct: 408 GAATPAAALGEVDSRVEVWRLPRGLAPGPLDAVSSKDFMPSCNLNFTLDLSRNNLVTIQQ 467 Query: 240 ASLKGLNNLAKLGLSFNSISAVDNGS-LANTPHLRELHLNNNKLVKVPG-GLADHKYIQV 297 L+ L L LS NSIS NGS LR L L++NKL G + ++ Sbjct: 468 EMFTRLSRLQCLRLSHNSISQAVNGSQFVPLTSLRVLDLSHNKLDLYHGRSFTELPQLEA 527 Query: 298 VYLHNNN 304 + L N+ Sbjct: 528 LDLSYNS 534 Score = 90.9 bits (224), Expect = 7e-19, Method: Composition-based stats. Identities = 47/202 (23%), Positives = 81/202 (40%), Gaps = 17/202 (8%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPG------AFAPLVKLERL 135 P L L +N I + L L N +S++ F L L +L Sbjct: 553 PSLRYLSLAHNGIHSRVSQKLSSAS-LRALDFSGNSLSQMWAEGDLYLCFFKGLRNLVQL 611 Query: 136 YLSKNQLKELPEK----MPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSG 191 LS+N L L + +PK+L++LR+ +N + S L ++ ++L N LK+ Sbjct: 612 DLSENHLHTLLPRHLDNLPKSLRQLRLRDNNLAFFNWSSLTVLPRLEALDLAGNQLKALS 671 Query: 192 IENGAFQGMKKLSYIRIADTNITTIPQGLP---PSLTELHLDGNKITKVDAASLKGLNN- 247 NG+ +L + ++ +I + G L EL+L N + VD + L Sbjct: 672 --NGSLPPGIRLQKLDVSSNSIGFVIPGFFVRATRLIELNLSANALKTVDPSWFGSLAGT 729 Query: 248 LAKLGLSFNSISAVDNGSLANT 269 L L +S N + + + Sbjct: 730 LKILDVSANPLHCACGAAFVDF 751 >3ULU-A nrPDB Length = 694 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 115/302 (38%), Gaps = 63/302 (20%) Query: 58 RCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNK 117 +C V CS L L +VP DLP + +L+L +N++ + +F L +L + N Sbjct: 11 KCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNT 70 Query: 118 ISKISPGAFAPLVKLERLYLSKNQLKELPEK---MPKTLQELRVHENEITKVRKSVFNGL 174 ISK+ P L L+ L L N+L +L +K L EL + N I K++ + F Sbjct: 71 ISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQ 130 Query: 175 NQMIVVELGTNPLKSSGIENGAFQGM------------------------KKLSYIRIAD 210 +I ++L N L S+ + L + ++ Sbjct: 131 KNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSS 190 Query: 211 TNITTIPQG-----------------LPPSLTE-------------LHLDGNKITKVDAA 240 I G L PSLTE L L ++++ Sbjct: 191 NQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNT 250 Query: 241 SLKGL--NNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPG----GLADHKY 294 + GL NL L LS+N+++ V N S A P L L N + + GL + +Y Sbjct: 251 TFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRY 310 Query: 295 IQ 296 + Sbjct: 311 LN 312 Score = 91.3 bits (225), Expect = 6e-19, Method: Composition-based stats. Identities = 63/256 (24%), Positives = 110/256 (42%), Gaps = 22/256 (8%) Query: 79 DLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLS 138 +L + + +I D F+ LK L L + +N I I F L+ L+ L LS Sbjct: 312 NLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLS 371 Query: 139 K--NQLKELPEKMPKTLQE-----LRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSG 191 L+ L + +L L + +N+I+K+ F+ L + V++LG N + Sbjct: 372 NSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEI-GQE 430 Query: 192 IENGAFQGMKKLSYIRIADTN---ITTIPQGLPPSLTELHLDGNKITKVD--AASLKGLN 246 + ++G++ + I ++ +T L PSL L L + VD + + L Sbjct: 431 LTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLR 490 Query: 247 NLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKV-----PGG----LADHKYIQV 297 NL L LS N+I+ +++ L L L L +N L ++ PGG L ++ + Sbjct: 491 NLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHI 550 Query: 298 VYLHNNNISAIGSNDF 313 + L +N I F Sbjct: 551 LNLESNGFDEIPVEVF 566 Score = 88.2 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 49/238 (20%), Positives = 98/238 (41%), Gaps = 21/238 (8%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKI-SKISPGAFAPLVKLERLYLSKNQLKEL 145 L+L NKI++I+ F L +L L L N+I +++ + L + +YLS N+ +L Sbjct: 396 LNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQL 455 Query: 146 ---PEKMPKTLQELRVHENEITKVRKSV--FNGLNQMIVVELGTNPLKSSGIENGAFQGM 200 + +LQ L + + V S F L + +++L + I + +G+ Sbjct: 456 TRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSN--NNIANINDDMLEGL 513 Query: 201 KKLSYIRIADTNITTIPQGLPPS-----------LTELHLDGNKITKVDAASLKGLNNLA 249 +KL + + N+ + + P L L+L+ N ++ K L L Sbjct: 514 EKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELK 573 Query: 250 KLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLA--DHKYIQVVYLHNNNI 305 + L N+++ + N L+ L+L N + V + + + + + N Sbjct: 574 IIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPF 631 Score = 70.1 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 54/273 (19%), Positives = 102/273 (37%), Gaps = 21/273 (7%) Query: 52 GPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTL 111 L ++ S ++ P + LDL +N ++ K G L+NL L Sbjct: 101 KTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQEL 160 Query: 112 ILINNKISKISPGAFA--PLVKLERLYLSKNQLKELPEKMPKTLQELR-VHENEIT---K 165 +L NNKI + L++L LS NQ+KE + L + N + Sbjct: 161 LLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPS 220 Query: 166 VRKSVFNGLNQ--MIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLP-- 221 + + + L + + L + L ++ L+ + ++ N+ + Sbjct: 221 LTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAW 280 Query: 222 -PSLTELHLDGNKITKVDAASLKGLNNLAKLGL---------SFNSISAVDNGSLANTPH 271 P L L+ N I + + SL GL N+ L L S S+ +D+ S Sbjct: 281 LPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKC 340 Query: 272 LRELHLNNNKLVKVPGGLAD-HKYIQVVYLHNN 303 L L++ +N + + + ++ + L N+ Sbjct: 341 LEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNS 373 Score = 60.1 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 49/196 (25%), Positives = 75/196 (38%), Gaps = 21/196 (10%) Query: 71 LGLEKVPKDLPPDTALLDLQNNKITEI--KDGDFKNLKNLHTLILINNKISKISPGAFAP 128 L L + L P L L+ + + F+ L+NL L L NN I+ I+ Sbjct: 453 LQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEG 512 Query: 129 LVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLK 188 L KLE L L N L L + GL+ + ++ L +N Sbjct: 513 LEKLEILDLQHNNLARLWKHANP-------------GGPIYFLKGLSHLHILNLESNGFD 559 Query: 189 SSGIENGAFQGMKKLSYIRIADTNITTIPQGLPP---SLTELHLDGNKITKVDAASL-KG 244 +E F+ + +L I + N+ T+P + SL L+L N IT V+ Sbjct: 560 EIPVE--VFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPA 617 Query: 245 LNNLAKLGLSFNSISA 260 NL +L + FN Sbjct: 618 FRNLTELDMRFNPFDC 633 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 26/150 (17%), Positives = 54/150 (36%), Gaps = 4/150 (2%) Query: 24 LFDFMLEDEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPD 83 + + + + E + P GP+ + HL ++ G +++P ++ D Sbjct: 509 MLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKD 568 Query: 84 ---TALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAP-LVKLERLYLSK 139 ++DL N + + F N +L +L L N I+ + F P L L + Sbjct: 569 LFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRF 628 Query: 140 NQLKELPEKMPKTLQELRVHENEITKVRKS 169 N E + + + I ++ Sbjct: 629 NPFDCTCESIAWFVNWINETHTNIPELSSH 658 >6HLU-A nrPDB Length = 974 Score = 155 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 80/294 (27%), Positives = 133/294 (45%), Gaps = 34/294 (11%) Query: 32 EASGIGPEEHFPEVP-------EIEPMGPVCPFRCQCHLRVVQCSDLGLEKV----PKDL 80 + + I P + +I + P+ L L K+ P + Sbjct: 102 QITDISPLASLNSLSMLWLDRNQITDIAPLASLNSLSML------WLFGNKISDIAPLES 155 Query: 81 PPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKN 140 L L +N+IT+I +LK+L L L N IS I+P L L L LS N Sbjct: 156 LKSLTELQLSSNQITDIAP--LASLKSLTELSLSGNNISDIAP--LESLKSLTELSLSSN 211 Query: 141 QLKEL-PEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQG 199 Q+ ++ P K+L EL + N+I+ + + L + ++L N + + Sbjct: 212 QITDIAPLASLKSLTELSLSSNQISDI--APLESLKSLTELQLSRNQISDI----APLES 265 Query: 200 MKKLSYIRIADTNITTI-PQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSI 258 +K L+ ++++ IT I P SLTEL L N+I+ + A L+ LN+L+KL L+ N I Sbjct: 266 LKSLTELQLSSNQITDIAPLASLKSLTELQLSRNQISDI--APLESLNSLSKLWLNGNQI 323 Query: 259 SAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSND 312 + + LA+ L EL L++N++ + LA K + ++L +N IS I Sbjct: 324 TDI--APLASLNSLTELELSSNQITDI-APLASLKSLSTLWLSSNQISDIAPLA 374 Score = 144 bits (362), Expect = 7e-35, Method: Composition-based stats. Identities = 79/293 (26%), Positives = 133/293 (45%), Gaps = 22/293 (7%) Query: 26 DFMLEDEASGIGPEEHFPEVPEIE----PMGPVCPFRCQCHLRVVQCSDLGLEKV-PKDL 80 ++ ++ S I P E + E++ + + P L + S + + P + Sbjct: 140 LWLFGNKISDIAPLESLKSLTELQLSSNQITDIAPLASLKSLTELSLSGNNISDIAPLES 199 Query: 81 PPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKN 140 L L +N+IT+I +LK+L L L +N+IS I+P L L L LS+N Sbjct: 200 LKSLTELSLSSNQITDIAP--LASLKSLTELSLSSNQISDIAP--LESLKSLTELQLSRN 255 Query: 141 QLKEL-PEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQG 199 Q+ ++ P + K+L EL++ N+IT + + L + ++L N + + Sbjct: 256 QISDIAPLESLKSLTELQLSSNQITDI--APLASLKSLTELQLSRNQISDI----APLES 309 Query: 200 MKKLSYIRIADTNITTI-PQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSI 258 + LS + + IT I P SLTEL L N+IT + A L L +L+ L LS N I Sbjct: 310 LNSLSKLWLNGNQITDIAPLASLNSLTELELSSNQITDI--APLASLKSLSTLWLSSNQI 367 Query: 259 SAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSN 311 S + LA+ L EL L++N++ + LA + + N I + Sbjct: 368 SDI--APLASLESLSELSLSSNQISDIS-PLASLNSLTGFDVRRNPIKRLPET 417 Score = 137 bits (345), Expect = 7e-33, Method: Composition-based stats. Identities = 72/250 (28%), Positives = 122/250 (48%), Gaps = 19/250 (7%) Query: 65 VVQCSDLGLEKV--PKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKIS 122 + C L+++ P + + L L +N+IT+I +L +L L L N+I+ I+ Sbjct: 72 LYDCGSDTLDRIIQPLESLKSLSELSLSSNQITDISP--LASLNSLSMLWLDRNQITDIA 129 Query: 123 PGAFAPLVKLERLYLSKNQLKEL-PEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVE 181 P A L L L+L N++ ++ P + K+L EL++ N+IT + + L + + Sbjct: 130 P--LASLNSLSMLWLFGNKISDIAPLESLKSLTELQLSSNQITDI--APLASLKSLTELS 185 Query: 182 LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTI-PQGLPPSLTELHLDGNKITKVDAA 240 L N + + +K L+ + ++ IT I P SLTEL L N+I+ + A Sbjct: 186 LSGNNISDI----APLESLKSLTELSLSSNQITDIAPLASLKSLTELSLSSNQISDI--A 239 Query: 241 SLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYL 300 L+ L +L +L LS N IS + L + L EL L++N++ + LA K + + L Sbjct: 240 PLESLKSLTELQLSRNQISDI--APLESLKSLTELQLSSNQITDI-APLASLKSLTELQL 296 Query: 301 HNNNISAIGS 310 N IS I Sbjct: 297 SRNQISDIAP 306 Score = 119 bits (299), Expect = 1e-27, Method: Composition-based stats. Identities = 57/211 (27%), Positives = 97/211 (45%), Gaps = 15/211 (7%) Query: 116 NKISKISPGAFAPLVKLERLYLSKNQLKEL-PEKMPKTLQELRVHENEITKVRKSVFNGL 174 N+I+ ISP A L L L+L +NQ+ ++ P +L L + N+I+ + + L Sbjct: 101 NQITDISP--LASLNSLSMLWLDRNQITDIAPLASLNSLSMLWLFGNKISDI--APLESL 156 Query: 175 NQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTI-PQGLPPSLTELHLDGNK 233 + ++L +N + +K L+ + ++ NI+ I P SLTEL L N+ Sbjct: 157 KSLTELQLSSNQITDI----APLASLKSLTELSLSGNNISDIAPLESLKSLTELSLSSNQ 212 Query: 234 ITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHK 293 IT + A L L +L +L LS N IS + L + L EL L+ N++ + L K Sbjct: 213 ITDI--APLASLKSLTELSLSSNQISDI--APLESLKSLTELQLSRNQISDI-APLESLK 267 Query: 294 YIQVVYLHNNNISAIGSNDFCPPGYNTKKAS 324 + + L +N I+ I + + Sbjct: 268 SLTELQLSSNQITDIAPLASLKSLTELQLSR 298 Score = 90.9 bits (224), Expect = 7e-19, Method: Composition-based stats. Identities = 51/180 (28%), Positives = 82/180 (45%), Gaps = 12/180 (6%) Query: 146 PEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSY 205 P + K+L EL + N+IT + S LN + ++ L N + + LS Sbjct: 86 PLESLKSLSELSLSSNQITDI--SPLASLNSLSMLWLDRNQITDI----APLASLNSLSM 139 Query: 206 IRIADTNITTI-PQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNG 264 + + I+ I P SLTEL L N+IT + A L L +L +L LS N+IS + Sbjct: 140 LWLFGNKISDIAPLESLKSLTELQLSSNQITDI--APLASLKSLTELSLSGNNISDI--A 195 Query: 265 SLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKAS 324 L + L EL L++N++ + LA K + + L +N IS I + + + Sbjct: 196 PLESLKSLTELSLSSNQITDI-APLASLKSLTELSLSSNQISDIAPLESLKSLTELQLSR 254 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 28/104 (26%), Positives = 44/104 (42%), Gaps = 13/104 (12%) Query: 232 NKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLAD 291 N+IT + L LN+L+ L L N I+ + LA+ L L L NK+ + L Sbjct: 101 NQITDISP--LASLNSLSMLWLDRNQITDI--APLASLNSLSMLWLFGNKISDI-APLES 155 Query: 292 HKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPV 335 K + + L +N I+ I S + +SL N + Sbjct: 156 LKSLTELQLSSNQITDIAPLA--------SLKSLTELSLSGNNI 191 Score = 47.8 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 32/150 (21%), Positives = 57/150 (38%), Gaps = 31/150 (20%) Query: 28 MLEDEASGIGPEEHFPEVPEIE----PMGPVCPFRCQCHLRVVQCSDLGLEKV-PKDLPP 82 + ++ + I P + E++ + + P L + + + + P Sbjct: 274 LSSNQITDIAPLASLKSLTELQLSRNQISDIAPLESLNSLSKLWLNGNQITDIAPLASLN 333 Query: 83 DTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKI----------------------SK 120 L+L +N+IT+I +LK+L TL L +N+I S Sbjct: 334 SLTELELSSNQITDIAP--LASLKSLSTLWLSSNQISDIAPLASLESLSELSLSSNQISD 391 Query: 121 ISPGAFAPLVKLERLYLSKNQLKELPEKMP 150 ISP A L L + +N +K LPE + Sbjct: 392 ISP--LASLNSLTGFDVRRNPIKRLPETIT 419 >4PUF-A nrPDB Length = 637 Score = 154 bits (388), Expect = 7e-38, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 119/272 (43%), Gaps = 27/272 (9%) Query: 71 LGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLK-NLHTLILINNKISKISPGAFAPL 129 LGL +P +P L L NN++ + + NL+ N+ TL +N+++ I P Sbjct: 60 LGLTTIPAYIPEQITTLILDNNELKSLPE----NLQGNIKTLYANSNQLTSI-PATLPD- 113 Query: 130 VKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKS 189 ++ + LS N++ ELPE++P LQ L + N+I+ + +++ L + V + Sbjct: 114 -TIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYD-------- 164 Query: 190 SGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLA 249 + I +++++ + ++T +P+ LPP L L N +T + A+ L Sbjct: 165 NSIRTLPAHLPSEITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLP---PELQ 221 Query: 250 KLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIG 309 L +S N I+ + P + L ++ N L +P L +Q++ NN+ + Sbjct: 222 VLDVSKNQITVLPETLP---PTITTLDVSRNALTNLPENLPAA--LQIMQASRNNLVRLP 276 Query: 310 SNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQ 341 + G + + NP IQ Sbjct: 277 ESLPHFRGEGPQPTRII---VEYNPFSERTIQ 305 Score = 122 bits (305), Expect = 3e-28, Method: Composition-based stats. Identities = 54/257 (21%), Positives = 101/257 (39%), Gaps = 47/257 (18%) Query: 40 EHFPEVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKD 99 E + P Q +++ + + L +P LP ++L N+ITE+ + Sbjct: 71 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPE 130 Query: 100 GDFKNLKN-LHTLILINNKISKISPGAFAPLV-KLERLYLSKNQLKELPEKMPKTLQELR 157 L + L +L L +NKIS + L +L L + N ++ LP +P + L Sbjct: 131 ----RLPSALQSLDLFHNKISCLPE----NLPEELRYLSVYDNSIRTLPAHLPSEITHLN 182 Query: 158 VHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIP 217 V N +T + +++ GL + + +T++P Sbjct: 183 VQSNSLTALPETLPPGLK-----------------------------TLEAGENALTSLP 213 Query: 218 QGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTP-HLRELH 276 LPP L L + N+IT + + L +S N+++ + N P L+ + Sbjct: 214 ASLPPELQVLDVSKNQITVLPETLPPTIT---TLDVSRNALTNLP----ENLPAALQIMQ 266 Query: 277 LNNNKLVKVPGGLADHK 293 + N LV++P L + Sbjct: 267 ASRNNLVRLPESLPHFR 283 Score = 62.0 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 34/177 (19%), Positives = 68/177 (38%), Gaps = 32/177 (18%) Query: 187 LKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLN 246 LK G+ ++++ + + + + ++P+ L ++ L+ + N++T + A + Sbjct: 57 LKILGLTTIPAYIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQ 116 Query: 247 N------------------LAKLGLSFNSISAVDNGSLANTP-HLRELHLNNNKLVKVPG 287 L L L N IS + N P LR L + +N + +P Sbjct: 117 EMELSINRITELPERLPSALQSLDLFHNKISCLP----ENLPEELRYLSVYDNSIRTLPA 172 Query: 288 GLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPST 344 L I + + +N+++A+ PPG K +L S P + P Sbjct: 173 HLPS--EITHLNVQSNSLTALPET--LPPG--LKTLEAGENALTSLP---ASLPPEL 220 Score = 60.1 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 29/112 (25%), Positives = 57/112 (50%), Gaps = 10/112 (8%) Query: 201 KKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISA 260 + +R+ +TTIP +P +T L LD N++ + L+G N+ L + N +++ Sbjct: 50 NNKTELRLKILGLTTIPAYIPEQITTLILDNNELKSLPEN-LQG--NIKTLYANSNQLTS 106 Query: 261 VDNGSLANTP-HLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSN 311 + A P ++E+ L+ N++ ++P L +Q + L +N IS + N Sbjct: 107 IP----ATLPDTIQEMELSINRITELPERLPSA--LQSLDLFHNKISCLPEN 152 Score = 46.2 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 24/131 (18%), Positives = 42/131 (32%), Gaps = 8/131 (6%) Query: 18 PFQQKGLFDFMLEDEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVP 77 P + L A + E P L+V+ S + +P Sbjct: 175 PSEITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLP 234 Query: 78 KDLPPDTALLDLQNNKITEIKDGDFKNLK-NLHTLILINNKISKIS---PGAFAPLVKLE 133 + LPP LD+ N +T + + NL L + N + ++ P + Sbjct: 235 ETLPPTITTLDVSRNALTNLPE----NLPAALQIMQASRNNLVRLPESLPHFRGEGPQPT 290 Query: 134 RLYLSKNQLKE 144 R+ + N E Sbjct: 291 RIIVEYNPFSE 301 >2Z7X-B nrPDB Length = 520 Score = 151 bits (382), Expect = 3e-37, Method: Composition-based stats. Identities = 75/284 (26%), Positives = 117/284 (41%), Gaps = 26/284 (9%) Query: 65 VVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPG 124 +V S GL VPKDL T +L++ N I+E+ D +L L LI+ +N+I + Sbjct: 4 LVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDIS 63 Query: 125 AFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVR-KSVFNGLNQMIVVELG 183 F +LE L LS N+L ++ L+ L + N + F ++Q+ + L Sbjct: 64 VFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLS 123 Query: 184 TNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTE-LHL---DGNKITKVDA 239 T L+ S + A + K+ + P+GL TE LH+ + + Sbjct: 124 TTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILD 183 Query: 240 ASLKGLNNLA----KLGLSFNSISAVDN--GSLANTPHLRELHLNN-----NKLVKVPGG 288 S+K + NL K L N S + L P L L LNN N +++ Sbjct: 184 VSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRI--- 240 Query: 289 LADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFS 332 L + V Y +N+ G DF + YSG SL + Sbjct: 241 LQLVWHTTVWYFSISNVKLQGQLDF-------RDFDYSGTSLKA 277 Score = 70.5 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 37/162 (22%), Positives = 66/162 (40%), Gaps = 5/162 (3%) Query: 146 PEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSY 205 P K+ L L N +T L ++ + L N LK MK L Sbjct: 320 PSKISPFL-HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQ 378 Query: 206 IRIADTNITTIPQGLPPSLTELHLDGNKITKVDAAS-LKGL-NNLAKLGLSFNSISAVDN 263 + I+ +++ + S T+ L N + + + + L + L L N I ++ Sbjct: 379 LDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIP- 437 Query: 264 GSLANTPHLRELHLNNNKLVKVPGGLAD-HKYIQVVYLHNNN 304 + L+EL++ +N+L VP G+ D +Q ++LH N Sbjct: 438 KQVVKLEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTNP 479 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 15/90 (16%), Positives = 36/90 (40%), Gaps = 3/90 (3%) Query: 30 EDEASGIGPEEHFPEVPEIEPMGPVCPFRCQCH-LRVVQCSDLGLEKVPKDLP--PDTAL 86 +++ + + + FRC ++V+ ++ +PK + Sbjct: 389 DEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQE 448 Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINN 116 L++ +N++ + DG F L +L + L N Sbjct: 449 LNVASNQLKSVPDGIFDRLTSLQKIWLHTN 478 Score = 32.4 bits (72), Expect = 0.32, Method: Composition-based stats. Identities = 53/366 (14%), Positives = 103/366 (28%), Gaps = 83/366 (22%) Query: 62 HLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKD-GDFKNLKNLHTLILINNKISK 120 L + S L K+ + LDL N + +F N+ L L L + K Sbjct: 70 ELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEK 129 Query: 121 I-------------------------SPGAFA--PLVKLERLYLSKNQLKELPEKMPKTL 153 P L ++ + + + + KT+ Sbjct: 130 SSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTV 189 Query: 154 QELRVHE-------NEITKVRKSVFNGLNQMIVVELGTNPLKSS---------------- 190 L + N+ + + + L N ++++ Sbjct: 190 ANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTV 249 Query: 191 ---GIENGAFQGMKKLSYIRIADTNITTIPQ--------GLPPSLTELHLDGNKITKVDA 239 I N QG + T++ + G P S I Sbjct: 250 WYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTV 309 Query: 240 ASLKGLNNL--------AKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVP---GG 288 + + ++ L L S N ++ + + L L L N+L ++ Sbjct: 310 SGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEM 369 Query: 289 LADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPSTFRCV 348 K +Q + + N++S C + S +++ SN + + FRC+ Sbjct: 370 TTQMKSLQQLDISQNSVSYDEKKGDC-----SWTKSLLSLNMSSNILTD-----TIFRCL 419 Query: 349 YVRAAV 354 R V Sbjct: 420 PPRIKV 425 >3B2D-A nrPDB Length = 603 Score = 150 bits (379), Expect = 8e-37, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 109/303 (35%), Gaps = 57/303 (18%) Query: 63 LRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKIS 122 + C +LGL ++P LP T L+ N + I + F L NL L L +I+ I Sbjct: 11 NKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIH 70 Query: 123 PGAFAPLVKLERLYLSKNQLKELPEKM---PKTLQELRVHENEITKVRKSVFNGLNQMIV 179 F +L L L+ N L + E PK+L+ L + + I+ + + L + Sbjct: 71 EDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLES 130 Query: 180 VELGTNPLKS------------------------------------------------SG 191 + LG+N + S G Sbjct: 131 LYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKG 190 Query: 192 IENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGN----KITKVDAASLKGLNN 247 IE GAF S N++ I GL S T+ G + +A LKGL Sbjct: 191 IELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCE 250 Query: 248 LAK--LGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNI 305 ++ L L + S + + + L+EL L L +P G+ ++ + L N+ Sbjct: 251 MSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHF 310 Query: 306 SAI 308 + Sbjct: 311 DQL 313 Score = 89.0 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 75/362 (20%), Positives = 130/362 (35%), Gaps = 65/362 (17%) Query: 7 FLLVAQVSWAGPFQQKGLFDFMLEDEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVV 66 + +A+ S GP K LF +GI E P V +E + + Sbjct: 90 LIFMAETSLNGPKSLKHLFLI-----QTGISNLEFIP-VHNLENLESLYLGSNHISS--- 140 Query: 67 QCSDLGLEKVPKDLPP-DTALLDLQNNKITEIKDGDFKNLKNLH--TLILINNKISKISP 123 K PKD P + +LD QNN I I D ++L+ +L N + I Sbjct: 141 -------IKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIEL 193 Query: 124 GAFA----------PLVKLERL-----------------------YLSKNQLKELPEKMP 150 GAF L + +S LK L E Sbjct: 194 GAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEM-- 251 Query: 151 KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIAD 210 +++ L + E+ + + + F Q+ ++L LK +G+ L + ++ Sbjct: 252 -SVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGL---PSGMKGLNLLKKLVLSV 307 Query: 211 TN---ITTIPQGLPPSLTELHLDGN-KITKVDAASLKGLNNLAKLGLSFNSI--SAVDNG 264 + + I PSLT L++ GN K + L+ L NL L LS N I S + Sbjct: 308 NHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSL 367 Query: 265 SLANTPHLRELHLNNNKLVKV-PGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKA 323 L N HL+ L+L++N+ + + + ++++ L + + + Sbjct: 368 QLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVL 427 Query: 324 SY 325 + Sbjct: 428 NL 429 Score = 86.7 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 45/243 (18%), Positives = 90/243 (37%), Gaps = 13/243 (5%) Query: 83 DTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ- 141 L+LQ ++ ++I F+ L L L + + G L L++L LS N Sbjct: 252 SVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGM-KGLNLLKKLVLSVNHF 310 Query: 142 --LKELPEKMPKTLQELRVHEN-EITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQ 198 L ++ +L L + N + + L + ++L N +++S + + Sbjct: 311 DQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLK 370 Query: 199 GMKKLSYIRIADTNITTIPQGLP---PSLTELHLDGNKIT-KVDAASLKGLNNLAKLGLS 254 + L + ++ + P L L L ++ + + L+ L L L+ Sbjct: 371 NLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLT 430 Query: 255 FNSISAVDNGSLANTPHLRELHLNNNKLVKVPGG----LADHKYIQVVYLHNNNISAIGS 310 + + + LA P LR L+L N L ++V+ L + + +I Sbjct: 431 YCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQ 490 Query: 311 NDF 313 F Sbjct: 491 QAF 493 Score = 64.7 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 43/214 (20%), Positives = 77/214 (35%), Gaps = 26/214 (12%) Query: 57 FRCQCHLRVVQCSD---LGLEKVPKDLPPDTALLDLQNNKIT-EIKDGDFKNLKNLHTLI 112 + HL+ + S LGL+ P LLDL ++ F+NL L L Sbjct: 369 LKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLN 428 Query: 113 LINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFN 172 L + + A L L L L N + + T + ++ Sbjct: 429 LTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQ------------------DGTITKTNLLQ 470 Query: 173 GLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLT--ELHLD 230 + + V+ L + L I+ AF + K+S++ ++ ++T L L+L Sbjct: 471 TVGSLEVLILSSCGL--LSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLA 528 Query: 231 GNKITKVDAASLKGLNNLAKLGLSFNSISAVDNG 264 N I + L L+ + + LS N + + Sbjct: 529 ANSINIISPRLLPILSQQSTINLSHNPLDCTCSN 562 >5XJX-C nrPDB Length = 433 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 60/245 (24%), Positives = 102/245 (41%), Gaps = 29/245 (11%) Query: 69 SDLGLEKVPKDLPP--DTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAF 126 + L +P +L + +LDL N + F L +L L N+++ PG Sbjct: 141 ENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFV 200 Query: 127 APLVKLERLYLSKNQLK-ELPEKMPK--TLQELRVHENEITKVRKSVFNGLNQMIVVELG 183 L L L L++N L +P + +L ++ + N +T N LNQ+++++L Sbjct: 201 --LPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLS 258 Query: 184 TNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLK 243 N L SG + QG+ L + + + T + + K Sbjct: 259 YNRL--SGPFPSSLQGLNSLQALMLKGNTKFS-------------------TTIPENAFK 297 Query: 244 GLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLV-KVPGGLADHKYIQVVYLHN 302 GL NL L LS +I SL LR LHL N L ++P D K++ + L++ Sbjct: 298 GLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLND 357 Query: 303 NNISA 307 N+++ Sbjct: 358 NSLTG 362 Score = 109 bits (273), Expect = 1e-24, Method: Composition-based stats. Identities = 51/255 (20%), Positives = 98/255 (38%), Gaps = 30/255 (11%) Query: 66 VQCSDLGLEKVPKDLP---PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKIS 122 +C +++P L L L+ N + NL NL L L N ++ Sbjct: 113 YRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSI 172 Query: 123 PGAFAPLVKLERLYLSKNQLK-ELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVE 181 P +F L L LS N+L +P + L L +++N +T +I ++ Sbjct: 173 PLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKID 232 Query: 182 LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAAS 241 L N + +G + + +L + ++ ++ +S Sbjct: 233 LSRN--RVTGPIPESINRLNQLVLLDLSYNRLSGPF---------------------PSS 269 Query: 242 LKGLNNLAKLGLSFNS--ISAVDNGSLANTPHLRELHLNNNKLV-KVPGGLADHKYIQVV 298 L+GLN+L L L N+ + + + +L L L+N + +P L ++V+ Sbjct: 270 LQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVL 329 Query: 299 YLHNNNISAIGSNDF 313 +L NN++ +F Sbjct: 330 HLEGNNLTGEIPLEF 344 Score = 38.9 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 18/93 (19%), Positives = 32/93 (34%), Gaps = 2/93 (2%) Query: 242 LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVK-VPGGLADHKYIQVVYL 300 LK L L + + L+ L L N + +P L + ++V+ L Sbjct: 104 LKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDL 163 Query: 301 HNNNISAIGSNDFCPPGYNTKKASYSGVSLFSN 333 H N+++ F + SG L + Sbjct: 164 HKNHLNGSIPLSF-NRFSGLRSLDLSGNRLTGS 195 >4R6F-A nrPDB Length = 331 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 63/244 (25%), Positives = 111/244 (45%), Gaps = 25/244 (10%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELP 146 L+L NN++ + G F+ L NL TL L NN+++ + G F L L L LS N + + Sbjct: 90 LNLSNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNNNIANIN 149 Query: 147 EKMPK---TLQELRVHENEITKVRKSV--------FNGLNQMIVVELGTNPLKSSGIENG 195 ++M + L L + N + ++ K GL + + L +N I Sbjct: 150 DQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDE--IPRE 207 Query: 196 AFQGMKKLSYIRIADTNITTIPQGL---PPSLTELHLDGNKITKVDAAS--------LKG 244 F+ + L+ + +++ NI I + +LT L+L N + ++ + LKG Sbjct: 208 VFKDLTSLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKG 267 Query: 245 LNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLAD-HKYIQVVYLHNN 303 L NL L LS N + + L L+L+NN+L +P G+ + ++ + L NN Sbjct: 268 LTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNQLTSLPQGVFERLTNLKTLNLSNN 327 Query: 304 NISA 307 + + Sbjct: 328 QLQS 331 Score = 141 bits (354), Expect = 7e-34, Method: Composition-based stats. Identities = 70/276 (25%), Positives = 120/276 (43%), Gaps = 29/276 (10%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 P+ L L NK+ +I K L NL L L NN++ + G F L L L LS NQ Sbjct: 63 PNVRYLALGGNKLHDI--SALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQ 120 Query: 142 LKELPEKMPK---TLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGA-- 196 L LP+ + + +L L + N I + + GL + + L N L Sbjct: 121 LTSLPQGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGG 180 Query: 197 ----FQGMKKLSYIRIADTNITTIPQGLP---PSLTELHLDGNKITKVDAASLKGLNNLA 249 +G+ L+ + ++ IP+ + SLT L+L N I ++ L+GL NL Sbjct: 181 PIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQMLEGLTNLT 240 Query: 250 KLGLSFNSISAV--------DNGSLANTPHLRELHLNNNKLVKVPGGLA-DHKYIQVVYL 300 L LS N+++ + L +L L+L++N ++P + D + + L Sbjct: 241 TLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNL 300 Query: 301 HNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQ 336 NN ++++ P G + + ++L +N +Q Sbjct: 301 SNNQLTSL------PQGVFERLTNLKTLNLSNNQLQ 330 Score = 82.5 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 43/180 (23%), Positives = 76/180 (42%), Gaps = 14/180 (7%) Query: 24 LFDFMLEDEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPD 83 + + + + P GP+ + +L + S G +++P+++ D Sbjct: 152 MLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKD 211 Query: 84 ---TALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGA--------FAPLVKL 132 L+L NN I I D + L NL TL L +N ++++ A L L Sbjct: 212 LTSLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNL 271 Query: 133 ERLYLSKNQLKELPEKMPK---TLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKS 189 L LS N E+P ++ K +L L + N++T + + VF L + + L N L+S Sbjct: 272 TTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNQLTSLPQGVFERLTNLKTLNLSNNQLQS 331 Score = 70.9 bits (172), Expect = 9e-13, Method: Composition-based stats. Identities = 34/165 (20%), Positives = 69/165 (41%), Gaps = 6/165 (3%) Query: 198 QGMKKLSYIRIADTNITTIPQ-GLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFN 256 Q + + Y+ + + I +L L+L N++ + + L NL L LS N Sbjct: 60 QYLPNVRYLALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNN 119 Query: 257 SISAVDNGSLANTPHLRELHLNNNKLVKVPGG-LADHKYIQVVYLHNNNISAI--GSNDF 313 ++++ G L L+L+NN + + L + + L +NN++ + +N Sbjct: 120 QLTSLPQGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPG 179 Query: 314 CPPGYNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRAAVQLGN 358 P + + + ++L SN + EI F+ + + L N Sbjct: 180 GPIYFLKGLTNLTTLNLSSNG--FDEIPREVFKDLTSLTTLNLSN 222 Score = 34.3 bits (77), Expect = 0.093, Method: Composition-based stats. Identities = 17/80 (21%), Positives = 33/80 (41%), Gaps = 7/80 (8%) Query: 256 NSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCP 315 N+ + P++R L L NKL + L + + + L NN + + P Sbjct: 49 NNSDIKSVQGIQYLPNVRYLALGGNKLHDISA-LKELTNLGWLNLSNNQLETL------P 101 Query: 316 PGYNTKKASYSGVSLFSNPV 335 G K + + ++L +N + Sbjct: 102 QGVFEKLTNLTTLNLSNNQL 121 >2XOT-A nrPDB Length = 361 Score = 139 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 65/230 (28%), Positives = 99/230 (43%), Gaps = 25/230 (10%) Query: 55 CPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIK-DGDFKNLKNLHTLIL 113 CP C C ++ CS L VP+ LP TALLDL +N ++ ++ + L NLH+L+L Sbjct: 12 CPANCLCASNILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLL 71 Query: 114 INNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELR---VHENEITKVRKSV 170 +N ++ IS AF P+ L L LS N L L E + LQ L ++ N I V ++ Sbjct: 72 SHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNA 131 Query: 171 FNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLD 230 F + Q+ + L N + +E + + P L L L Sbjct: 132 FEDMAQLQKLYLSQNQISRFPVE------------LIKDGNKL--------PKLMLLDLS 171 Query: 231 GNKITKVDAASLKGLNNLAKLGLS-FNSISAVDNGSLANTPHLRELHLNN 279 NK+ K+ L+ L K GL N+ D H + L++ Sbjct: 172 SNKLKKLPLTDLQKLPAWVKNGLYLHNNPLECDCKLYQLFSHWQYRQLSS 221 Score = 88.6 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 43/207 (20%), Positives = 78/207 (37%), Gaps = 32/207 (15%) Query: 135 LYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSV-FNGLNQMIVVELGTNPLKSSGIE 193 L SK QL +P+ +P L + N ++++R L + + L N L Sbjct: 23 LSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHL------ 76 Query: 194 NGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGL 253 I++ P+L L L N + +D L L L L Sbjct: 77 -----------------NFISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLL 119 Query: 254 SFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGL----ADHKYIQVVYLHNNNISAIG 309 N I VD + + L++L+L+ N++ + P L + ++ L +N + + Sbjct: 120 YNNHIVVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLP 179 Query: 310 SNDFCPPGYNTKKASYSGVSLFSNPVQ 336 D K +G+ L +NP++ Sbjct: 180 LTDLQKLPAWVK----NGLYLHNNPLE 202 >3J0A-A nrPDB Length = 844 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 72/286 (25%), Positives = 118/286 (41%), Gaps = 67/286 (23%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 LDL + + + F+ LK+L L L NKI+KI+ AF L L+ L LS N Sbjct: 266 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 325 Query: 142 LKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMK 201 L EL S F GL ++ ++L N + + I++ F+ ++ Sbjct: 326 LGEL---------------------YSSNFYGLPKVAYIDLQKNHI--AIIQDQTFKFLE 362 Query: 202 KLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAV 261 KL + + D +TTI PS+ ++ L GNK+ + +L + LS N + + Sbjct: 363 KLQTLDLRDNALTTI--HFIPSIPDIFLSGNKLVTLPKINLTA----NLIHLSENRLENL 416 Query: 262 DN-GSLANTPHLRELHLNNNKLVKVPG-------------------------------GL 289 D L PHL+ L LN N+ G Sbjct: 417 DILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVF 476 Query: 290 ADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPV 335 ++QV+YL++N ++++ PPG + + G+SL SN + Sbjct: 477 EGLSHLQVLYLNHNYLNSL------PPGVFSHLTALRGLSLNSNRL 516 Score = 93.2 bits (230), Expect = 1e-19, Method: Composition-based stats. Identities = 57/287 (19%), Positives = 102/287 (35%), Gaps = 56/287 (19%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISK--ISPGAFAPLVKLERLYLSK 139 P+ +LDL ++KI + F+ L +L L L +S + G F L L RL LSK Sbjct: 73 PNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSK 132 Query: 140 NQLKEL----PEKMPKTLQELRVHENEITKVRKSVFNGL--NQMIVVELGTNPLKSSGIE 193 NQ++ L +L+ + N+I V + L + L N L S Sbjct: 133 NQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSV 192 Query: 194 N-----GAFQGMKKLSYIRIADTNITTIPQGLPP-------------------------- 222 + F+ M L + ++ T G Sbjct: 193 DWGKCMNPFRNMV-LEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHN 251 Query: 223 ---------------SLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLA 267 S+ L L + +++ + L +L L L++N I+ + + + Sbjct: 252 IKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFY 311 Query: 268 NTPHLRELHLNNNKLVKV-PGGLADHKYIQVVYLHNNNISAIGSNDF 313 +L+ L+L+ N L ++ + + L N+I+ I F Sbjct: 312 GLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTF 358 Score = 82.8 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 64/335 (19%), Positives = 108/335 (32%), Gaps = 80/335 (23%) Query: 58 RCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDF--------------- 102 C R+ L +VP+ L T L L N I + F Sbjct: 1 SCSFDGRIAFYRFCNLTQVPQVL-NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQY 59 Query: 103 ----------KNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPE----- 147 +NL NL L L ++KI + P AF L L L L L + Sbjct: 60 TPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYF 119 Query: 148 KMPKTLQELRVHENEITKVRKSV-FNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYI 206 + K L L + +N+I + F LN + ++ +N + K LS+ Sbjct: 120 RNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFF 179 Query: 207 RIADTNI---------TTIPQGLPPSLTELHLDGN------------------------- 232 +A ++ + L L + GN Sbjct: 180 SLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILA 239 Query: 233 -----------KITKVDAASLKGL--NNLAKLGLSFNSISAVDNGSLANTPHLRELHLNN 279 I D + GL +++ L LS + ++++ L+ L+L Sbjct: 240 HHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAY 299 Query: 280 NKLVKVPGGLAD-HKYIQVVYLHNNNISAIGSNDF 313 NK+ K+ +QV+ L N + + S++F Sbjct: 300 NKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNF 334 Score = 67.0 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 31/112 (27%), Positives = 51/112 (45%), Gaps = 9/112 (8%) Query: 82 PDTALLDLQNNKI-----TEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLY 136 P L L N + TE+ F+ L +L L L +N ++ + PG F+ L L L Sbjct: 451 PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLS 510 Query: 137 LSKNQLKELP-EKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPL 187 L+ N+L L +P L+ L + N++ VF L+ V+++ N Sbjct: 511 LNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLS---VLDITHNKF 559 Score = 33.5 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 20/103 (19%), Positives = 35/103 (33%), Gaps = 5/103 (4%) Query: 28 MLEDEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPK-DLPPDTAL 86 + D G+ + P F LR + + L + DLP + + Sbjct: 471 LCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEI 530 Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNK-ISKISPGAFAP 128 LD+ N++ F +L L + +NK I + F Sbjct: 531 LDISRNQLLAPNPDVFVSLS---VLDITHNKFICECELSTFIN 570 >2V9T-B nrPDB Length = 220 Score = 136 bits (342), Expect = 1e-32, Method: Composition-based stats. Identities = 50/162 (30%), Positives = 82/162 (50%), Gaps = 5/162 (3%) Query: 55 CPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILI 114 CP C C +V C GL ++P +LP + L+ N I I G F K L + L Sbjct: 5 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 64 Query: 115 NNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPK---TLQELRVHENEITKVRKSVF 171 NN+IS+++P AF L L L L N++ ELP+ + + +LQ L ++ N+I +R F Sbjct: 65 NNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAF 124 Query: 172 NGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNI 213 L+ + ++ L N L++ I G F ++ + + +A Sbjct: 125 QDLHNLNLLSLYDNKLQT--IAKGTFSPLRAIQTMHLAQNPF 164 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 45/178 (25%), Positives = 81/178 (45%), Gaps = 10/178 (5%) Query: 142 LKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMK 201 L E+P +P+T+ E+R+ +N I + F+ ++ ++L N + + AFQG++ Sbjct: 23 LTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISE--LAPDAFQGLR 80 Query: 202 KLSYIRIADTNITTIPQGLPPSLTELHL---DGNKITKVDAASLKGLNNLAKLGLSFNSI 258 L+ + + IT +P+ L L L L + NKI + + + L+NL L L N + Sbjct: 81 SLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKL 140 Query: 259 SAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPP 316 + G+ + ++ +HL N + H YLH N I G+ P Sbjct: 141 QTIAKGTFSPLRAIQTMHLAQNPFI-----CDCHLKWLADYLHTNPIETSGARCTSPR 193 Score = 70.1 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 29/129 (22%), Positives = 49/129 (37%), Gaps = 25/129 (19%) Query: 212 NITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH 271 +T IP LP ++TE+ L+ N I + + L ++ LS N IS + + Sbjct: 22 GLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRS 81 Query: 272 LRELHLNNNKLVKVPGGLA-------------------------DHKYIQVVYLHNNNIS 306 L L L NK+ ++P L D + ++ L++N + Sbjct: 82 LNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQ 141 Query: 307 AIGSNDFCP 315 I F P Sbjct: 142 TIAKGTFSP 150 >3RG1-A nrPDB Length = 612 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 58/305 (19%), Positives = 110/305 (36%), Gaps = 61/305 (20%) Query: 63 LRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKIS 122 R C +LGL ++P LP T +L+ N + I++ F L NL L L +I+ + Sbjct: 13 NRTYNCENLGLREIPDTLPNTTEVLEFSFNFLPTIQNTTFSRLINLIFLDLTRCQINWVH 72 Query: 123 PGAFAPLVKLERLYLSKNQLKELPEKM---PKTLQELRVHENEITKVRKSVFNGLNQMIV 179 F +L + L+ N L + E PK L+ L + + I+ + + L + Sbjct: 73 EDTFQSHHQLNTIVLTGNPLIFMAETSLTGPKFLKHLFLTQTGISNLEFIPVHNLENLES 132 Query: 180 VELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTE-----LHLDGNKI 234 + LG+N + S + + L + + I I + SL + L+ +GN I Sbjct: 133 LHLGSNHISSINLPENF--PTQNLKVLDFQNNAIHYISRKDTNSLEQATNLSLNFNGNDI 190 Query: 235 TKVDAAS--------------------LKGLNN--------------------------- 247 ++ + KGL N Sbjct: 191 KGIEPGAFISKIFQSLKFGGSLNLFIIFKGLQNSTLQSLWLGTFEDTDDQYLTSATFEGL 250 Query: 248 ----LAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNN 303 + + L + S + + + ++EL L L +P G+ ++ + L+ N Sbjct: 251 CDMSVESINLQKHRFSDLSSSTFRCFTRVQELDLTAAHLNGLPSGIEGMNSLKKLVLNAN 310 Query: 304 NISAI 308 + + Sbjct: 311 SFDQL 315 Score = 96.7 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 76/373 (20%), Positives = 133/373 (35%), Gaps = 60/373 (16%) Query: 12 QVSWAGPFQQ-------KGLFDFMLEDEASGIGPEEH-FPEVPEIEPMGPVCPFRCQCHL 63 Q W G F+ F+ + + I ++H F ++ FRC + Sbjct: 227 QSLWLGTFEDTDDQYLTSATFEGLCDMSVESINLQKHRFSDLSSST-------FRCFTRV 279 Query: 64 RVVQCSDLGLEKVPKDLP--PDTALLDLQNN---KITEIKDGDF---------------- 102 + + + L +P + L L N ++ +I F Sbjct: 280 QELDLTAAHLNGLPSGIEGMNSLKKLVLNANSFDQLCQINAASFPSLRDLYIKGNMRKLD 339 Query: 103 ------KNLKNLHTLILINNKI--SKISPGAFAPLVKLERLYLSKNQ---LKELPEKMPK 151 + L+NL L L ++ I S L L+ L LS N+ L++ K Sbjct: 340 LGTRCLEKLENLQKLDLSHSDIEASDCCNLQLKNLRHLQYLNLSYNEPLGLEDQAFKECP 399 Query: 152 TLQELRVHENEIT-KVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIAD 210 L+ L V + K S F L+ + V+ L L +S G++ L ++ + Sbjct: 400 QLELLDVAFTHLHVKAPHSPFQNLHLLRVLNLSHCLLDTSNQH--LLAGLQDLRHLNLQG 457 Query: 211 TNITTIPQGLPP------SLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNG 264 + SL L L + +D + GL N+ L LS NS++ Sbjct: 458 NSFQDGSISKTNLLQMVGSLEILILSSCNLLSIDQQAFHGLRNVNHLDLSHNSLTGDSMD 517 Query: 265 SLANTPHLRELHLNNNKLVKVPGGLADHKYIQ-VVYLHNNNISAIGSNDFCPPGY--NTK 321 +L++ L L++ +N + +P L Q ++ L +N + SN Y N Sbjct: 518 ALSHLKGL-YLNMASNNIRIIPPHLLPALSQQSIINLSHNPLDCTCSNIHFITWYKENLH 576 Query: 322 KASYSGVSLFSNP 334 K S + +NP Sbjct: 577 KLEDSEETTCANP 589 Score = 89.0 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 69/358 (19%), Positives = 129/358 (36%), Gaps = 55/358 (15%) Query: 7 FLLVAQVSWAGPFQQKGLFDFMLEDEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVV 66 + +A+ S GP K LF +GI E P V +E + + + Sbjct: 92 LIFMAETSLTGPKFLKHLFL-----TQTGISNLEFIP-VHNLENLESL----------HL 135 Query: 67 QCSDLGLEKVPKDLPP-DTALLDLQNNKITEIK---DGDFKNLKNLHTLILINNKISKIS 122 + + +P++ P + +LD QNN I I + NL +L N I I Sbjct: 136 GSNHISSINLPENFPTQNLKVLDFQNNAIHYISRKDTNSLEQATNL-SLNFNGNDIKGIE 194 Query: 123 PGAFAP----------------------LVKLERLYL------SKNQLKELPEKMP--KT 152 PGAF L+ L+L L + + Sbjct: 195 PGAFISKIFQSLKFGGSLNLFIIFKGLQNSTLQSLWLGTFEDTDDQYLTSATFEGLCDMS 254 Query: 153 LQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTN 212 ++ + + ++ + + S F ++ ++L L +KKL + Sbjct: 255 VESINLQKHRFSDLSSSTFRCFTRVQELDLTAAHLNGLPSGIEGMNSLKKLVLNANSFDQ 314 Query: 213 ITTIPQGLPPSLTELHLDGNKIT-KVDAASLKGLNNLAKLGLSFNSI--SAVDNGSLANT 269 + I PSL +L++ GN + L+ L NL KL LS + I S N L N Sbjct: 315 LCQINAASFPSLRDLYIKGNMRKLDLGTRCLEKLENLQKLDLSHSDIEASDCCNLQLKNL 374 Query: 270 PHLRELHLNNNKLVKVPGGLA-DHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYS 326 HL+ L+L+ N+ + + + ++++ + ++ + + + + S Sbjct: 375 RHLQYLNLSYNEPLGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQNLHLLRVLNLS 432 >5Y31-B nrPDB Length = 544 Score = 134 bits (336), Expect = 7e-32, Method: Composition-based stats. Identities = 42/146 (28%), Positives = 64/146 (43%), Gaps = 5/146 (3%) Query: 46 PEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNL 105 E P P CP C C C + +P+ +PPD L + TEI +G F Sbjct: 13 YEAYPAKPKCPAVCTCTKDNALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFT 70 Query: 106 KNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPE---KMPKTLQELRVHENE 162 +L L+ +N IS AF L LE L++ N +K + + K+L L + N Sbjct: 71 PSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNN 130 Query: 163 ITKVRKSVFNGLNQMIVVELGTNPLK 188 + + K +F GL+ + V+L N Sbjct: 131 LQTLPKDIFKGLDSLTNVDLRGNSFN 156 Score = 74.0 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 27/120 (22%), Positives = 50/120 (41%), Gaps = 5/120 (4%) Query: 144 ELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKL 203 +P +P + L + T++ + F + ++ +N I + AF G+ L Sbjct: 40 SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDV--ISDDAFIGLPHL 97 Query: 204 SYIRIADTNITTIPQGLPPSLTEL---HLDGNKITKVDAASLKGLNNLAKLGLSFNSISA 260 Y+ I + NI +I + L L L N + + KGL++L + L NS + Sbjct: 98 EYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNC 157 Score = 70.9 bits (172), Expect = 9e-13, Method: Composition-based stats. Identities = 24/111 (21%), Positives = 41/111 (36%), Gaps = 4/111 (3%) Query: 200 MKKLSYIRIADTNITTIPQG---LPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFN 256 + + + T I +G PSL L N + + GL +L L + N Sbjct: 46 PPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN 105 Query: 257 SISAVDNGSLANTPHLRELHLNNNKLVKVPGGLAD-HKYIQVVYLHNNNIS 306 +I ++ + L L L NN L +P + + V L N+ + Sbjct: 106 NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 156 Score = 70.1 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 1/103 (0%) Query: 212 NITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH 271 N +IP+ +PP + L + T++ S +L L + NS + + + PH Sbjct: 37 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPH 96 Query: 272 LRELHLNNNKLVKVPG-GLADHKYIQVVYLHNNNISAIGSNDF 313 L L + NN + + K + + L NNN+ + + F Sbjct: 97 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIF 139 >3T6Q-A nrPDB Length = 606 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 61/305 (20%), Positives = 108/305 (35%), Gaps = 61/305 (20%) Query: 63 LRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKIS 122 + C +LGL ++P LP T L+ N + I++ F L NL L L +I I Sbjct: 14 NKTYNCENLGLNEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIYWIH 73 Query: 123 PGAFAPLVKLERLYLSKNQLKELPEKM---PKTLQELRVHENEITKVRKSVFNGLNQMIV 179 F +L+ L L+ N L + E PK L+ L + I+ + + + Sbjct: 74 EDTFQSQHRLDTLVLTANPLIFMAETALSGPKALKHLFFIQTGISSIDFIPLHNQKTLES 133 Query: 180 VELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTE-----LHLDGNKI 234 + LG+N + S + G +KL + + I + + SL + L+L+GN I Sbjct: 134 LYLGSNHISSIKLPKGF--PTEKLKVLDFQNNAIHYLSKEDMSSLQQATNLSLNLNGNDI 191 Query: 235 TKVDAAS--------------------LKGLNN--------------------------- 247 ++ + KGL N Sbjct: 192 AGIEPGAFDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGL 251 Query: 248 ----LAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNN 303 + + L + + + + L+EL L L ++P GL ++ + L N Sbjct: 252 CEMSVESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSAN 311 Query: 304 NISAI 308 + Sbjct: 312 KFENL 316 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 71/338 (21%), Positives = 129/338 (38%), Gaps = 33/338 (9%) Query: 12 QVSWAGPFQQK-------GLFDFMLEDEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLR 64 Q W G F+ +F+ + E I ++H+ I F C L+ Sbjct: 228 QSLWLGTFEDMDDEDISPAVFEGLCEMSVESINLQKHY--FFNISSN----TFHCFSGLQ 281 Query: 65 VVQCSDLGLEKVPKDLP--PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKIS-KI 121 + + L ++P L L L NK + N +L L + N ++ Sbjct: 282 ELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLEL 341 Query: 122 SPGAFAPLVKLERLYLSKNQLK-----ELPEKMPKTLQELRVHENEITKVRKSVFNGLNQ 176 G L L L LS + ++ L + LQ L + NE ++ F Q Sbjct: 342 GTGCLENLENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQ 401 Query: 177 MIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLP---PSLTELHLDGNK 233 + +++L LK FQ + L + ++ + + + L P+L L+L GN Sbjct: 402 LELLDLAFTRLKVKD-AQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNH 460 Query: 234 ITK---VDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLA 290 K SL+ L L L LSF +S++D + + + + L++N+L + Sbjct: 461 FPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTS--SSIE 518 Query: 291 DHKYIQVVYLH--NNNISAIGSNDFCPPGYNTKKASYS 326 +++ +YL+ +N+IS I P + + Sbjct: 519 ALSHLKGIYLNLASNHISIILP-SLLPILSQQRTINLR 555 Score = 89.4 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 71/321 (22%), Positives = 124/321 (38%), Gaps = 31/321 (9%) Query: 7 FLLVAQVSWAGPFQQKGLFDFMLEDEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVV 66 + +A+ + +GP K LF +GI + P + + + + Sbjct: 93 LIFMAETALSGPKALKHLFFI-----QTGISSIDFIP-LHNQKTLESLYLGSNHISS--- 143 Query: 67 QCSDLGLEKVPKDLP-PDTALLDLQNNKITEIKDGDFKNLKNLH--TLILINNKISKISP 123 K+PK P +LD QNN I + D +L+ +L L N I+ I P Sbjct: 144 -------IKLPKGFPTEKLKVLDFQNNAIHYLSKEDMSSLQQATNLSLNLNGNDIAGIEP 196 Query: 124 GAFAPLVKLERLYLSKNQ-----LKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMI 178 GAF V + L Q K L ++L + + + +VF GL +M Sbjct: 197 GAFDSAV-FQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGLCEMS 255 Query: 179 VVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGL--PPSLTELHLDGNKITK 236 V + I + F L + + T+++ +P GL +L +L L NK Sbjct: 256 VESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFEN 315 Query: 237 VDAASLKGLNNLAKLGLSFNSIS-AVDNGSLANTPHLRELHLNNNKLVK---VPGGLADH 292 + S +L L + N+ + G L N +LREL L+++ + L + Sbjct: 316 LCQISASNFPSLTHLSIKGNTKRLELGTGCLENLENLRELDLSHDDIETSDCCNLQLRNL 375 Query: 293 KYIQVVYLHNNNISAIGSNDF 313 ++Q + L N ++ + F Sbjct: 376 SHLQSLNLSYNEPLSLKTEAF 396 Score = 74.0 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 42/211 (19%), Positives = 80/211 (37%), Gaps = 16/211 (7%) Query: 63 LRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKIS 122 + C +L L + L+L N+ +K FK L L L ++ Sbjct: 362 IETSDCCNLQLRNL-----SHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKD 416 Query: 123 PGA-FAPLVKLERLYLSKNQLKELPEKMP---KTLQELRVHENEITK---VRKSVFNGLN 175 + F L L+ L LS + L E++ LQ L + N K + + L Sbjct: 417 AQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLG 476 Query: 176 QMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLT--ELHLDGNK 233 ++ ++ L S I+ AF +K ++++ ++ +T+ L L+L N Sbjct: 477 RLEILVLSF--CDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNH 534 Query: 234 ITKVDAASLKGLNNLAKLGLSFNSISAVDNG 264 I+ + + L L+ + L N + + Sbjct: 535 ISIILPSLLPILSQQRTINLRQNPLDCTCSN 565 >3A79-B nrPDB Length = 562 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 53/214 (24%), Positives = 88/214 (41%), Gaps = 7/214 (3%) Query: 51 MGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHT 110 +G + PF + +V S+ L VPKDLPP T L L N I+E++ D L L Sbjct: 22 VGSMTPFSNELE-SMVDYSNRNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELRV 80 Query: 111 LILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVR-KS 169 L L +N+I + F LE L +S N+L+ + +L+ L + N+ + Sbjct: 81 LRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNISCCPMASLRHLDLSFNDFDVLPVCK 140 Query: 170 VFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLP-PSLTELH 228 F L ++ + L + + A + + ++ + L P+ T LH Sbjct: 141 EFGNLTKLTFLGLSAAKFRQLDLLPVAHLHLSCILLDLVSYHIKGGETESLQIPNTTVLH 200 Query: 229 L--DGNKITKVDAASLKGLNNLAKLGLSFNSISA 260 L N + V +N L L LS ++ Sbjct: 201 LVFHPNSLFSVQVNM--SVNALGHLQLSNIKLND 232 Score = 69.0 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 32/201 (15%), Positives = 74/201 (36%), Gaps = 26/201 (12%) Query: 83 DTALLDLQNN-KITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 + +L + + I + + L N + + L +L+ L L +N Sbjct: 332 NIKMLSISDTPFIHMVCPPSPSSFT---FLNFTQNVFTDSVFQGCSTLKRLQTLILQRNG 388 Query: 142 LKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMK 201 LK + T ++ + +++ N L S + + Sbjct: 389 LKNFFKVALMT-------------------KNMSSLETLDVSLNSLNSHAYDRTCAWA-E 428 Query: 202 KLSYIRIADTNIT-TIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISA 260 + + ++ +T ++ + LPP + L L N+I + + L L +L ++ N + + Sbjct: 429 SILVLNLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIPK-DVTHLQALQELNVASNQLKS 487 Query: 261 VDNGSLANTPHLRELHLNNNK 281 V +G L+ + L++N Sbjct: 488 VPDGVFDRLTSLQYIWLHDNP 508 Score = 59.0 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 47/262 (17%), Positives = 98/262 (37%), Gaps = 36/262 (13%) Query: 81 PPDTALLDLQNNKITE-IKDGDFK-NLKNLHTLILIN--NKISKISPGAFAPL---VKLE 133 P L++ N ITE I +F + L +L++ + N++ S A + + ++ Sbjct: 275 PRPVEYLNIYNLTITERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALYSVFAEMNIK 334 Query: 134 RLYLSKNQLKEL-PEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGI 192 L +S + P + L +N T + L ++ + L N LK+ Sbjct: 335 MLSISDTPFIHMVCPPSPSSFTFLNFTQNVFTDSVFQGCSTLKRLQTLILQRNGLKNFFK 394 Query: 193 ENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLG 252 + M L + ++ ++ + + E L L Sbjct: 395 VALMTKNMSSLETLDVSLNSLNSHAYDRTCAWAESIL--------------------VLN 434 Query: 253 LSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSND 312 LS N ++ L P ++ L L+NN+++ +P + + +Q + + +N + ++ Sbjct: 435 LSSNMLTGSVFRCLP--PKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNQLKSV---- 488 Query: 313 FCPPGYNTKKASYSGVSLFSNP 334 P G + S + L NP Sbjct: 489 --PDGVFDRLTSLQYIWLHDNP 508 Score = 53.9 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 1/62 (1%) Query: 80 LPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSK 139 LPP +LDL NN+I I D +L+ L L + +N++ + G F L L+ ++L Sbjct: 448 LPPKVKVLDLHNNRIMSIPK-DVTHLQALQELNVASNQLKSVPDGVFDRLTSLQYIWLHD 506 Query: 140 NQ 141 N Sbjct: 507 NP 508 Score = 31.6 bits (70), Expect = 0.52, Method: Composition-based stats. Identities = 16/96 (16%), Positives = 39/96 (40%), Gaps = 15/96 (15%) Query: 256 NSISAVDNGSLANTPHL--------RELHLNNNKLVKVPGG-LADHKYIQVVYLHNNNIS 306 N + ++ + S N H+ + L L+ N + ++ ++ ++V+ L +N I Sbjct: 30 NELESMVDYSNRNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIR 89 Query: 307 AIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQP 342 ++ + F + Y + + N +Q P Sbjct: 90 SLDFHVFL----FNQDLEY--LDVSHNRLQNISCCP 119 >3V44-A nrPDB Length = 407 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 66/262 (25%), Positives = 107/262 (40%), Gaps = 45/262 (17%) Query: 82 PDTALLDLQNNKITE--IKDGDFKNLKNLHTLILINNKISKISPGAF-APLVKLERLYLS 138 + +L L + + FK L +L L+L +N I KI P +F + + L L+ Sbjct: 103 ANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLT 162 Query: 139 KNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGT----NPLKSSGIE- 193 N++K + E+ L T +R S L M LG NP K++ I Sbjct: 163 FNKVKSICEE-----DLLNFQGKHFTLLRLSSIT-LQDMNEYWLGWEKCGNPFKNTSITT 216 Query: 194 -----NGAFQGMKKLSYIRIADTNITTIP------------------------QGLPPS- 223 NG + M K + IA T I ++ +GL S Sbjct: 217 LDLSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTNFKDPDNFTFKGLEASG 276 Query: 224 LTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLV 283 + L +KI + + +L +L L+ N I+ +D+ + HL+EL L+ N+L Sbjct: 277 VKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLTHLKELALDTNQLK 336 Query: 284 KVPGGLAD-HKYIQVVYLHNNN 304 VP G+ D +Q ++LH N Sbjct: 337 SVPDGIFDRLTSLQKIWLHTNP 358 Score = 95.2 bits (235), Expect = 4e-20, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 101/284 (35%), Gaps = 41/284 (14%) Query: 57 FRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINN 116 C C + GL +VP +LP +DL N I E+ + F L++L L Sbjct: 6 SECSVIGYNAICINRGLHQVP-ELPAHVNYVDLSLNSIAELNETSFSRLQDLQFL----- 59 Query: 117 KISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQ 176 K+ + +PG L + N + L +L L++ N+ ++ FNGL Sbjct: 60 KVEQQTPG----------LVIRNNTFRGLS-----SLIILKLDYNQFLQLETGAFNGLAN 104 Query: 177 MIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLT----ELHLDGN 232 + V+ L L + + F+ + L + + D NI I L L N Sbjct: 105 LEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFN 164 Query: 233 KITKVDAASLKGLNN--LAKLGLSFNSISAVDNGSLAN--------TPHLRELHLNNNKL 282 K+ + L L LS ++ ++ L + L L+ N Sbjct: 165 KVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGF 224 Query: 283 V-KVPGGLADH---KYIQVVYLHN--NNISAIGSNDFCPPGYNT 320 + D IQ + L N N S+ G +F P T Sbjct: 225 KESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTNFKDPDNFT 268 Score = 55.1 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 52/150 (34%), Gaps = 10/150 (6%) Query: 186 PLKSSGIENGAFQ---GMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITK----VD 238 + I G Q ++Y+ ++ +I + + L +L + + Sbjct: 12 GYNAICINRGLHQVPELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQTPGLVIR 71 Query: 239 AASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVK--VPGGLA-DHKYI 295 + +GL++L L L +N ++ G+ +L L L L + G + Sbjct: 72 NNTFRGLSSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSL 131 Query: 296 QVVYLHNNNISAIGSNDFCPPGYNTKKASY 325 +++ L +NNI I F Sbjct: 132 EMLVLRDNNIKKIQPASFFLNMRRFHVLDL 161 >4AY9-X nrPDB Length = 350 Score = 117 bits (293), Expect = 8e-27, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 107/265 (40%), Gaps = 57/265 (21%) Query: 55 CPFR-CQCHLRVVQCSDLGLEKVPKDLPP------------------------DTALLDL 89 C R C C RV C + + ++P DLP D +++ Sbjct: 2 CHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEI 61 Query: 90 QNNKITEIKDGD-FKNLKNLHTLIL-INNKISKISPGAFAPLVKLERLYLSKNQLKELPE 147 N + E+ + D F NL LH + + N + I+P AF L L+ L +S +K LP+ Sbjct: 62 SQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD 121 Query: 148 -KMPKTLQE--LRVHEN-EITKVRKSVFNGLN-QMIVVELGTNPLKSSGIENGAFQGMKK 202 +LQ+ L + +N I + ++ F GL+ + +++ L N ++ I N AF G + Sbjct: 122 VHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQE--IHNSAFNG-TQ 178 Query: 203 LSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVD 262 L + ++D N + ++ G + L +S I ++ Sbjct: 179 LDELNLSDN--------------------NNLEELPNDVFHGASGPVILDISRTRIHSLP 218 Query: 263 NGSLANTPHLRELHLNNNKLVKVPG 287 + L N LR + L K+P Sbjct: 219 SYGLENLKKLR--ARSTYNLKKLPT 241 Score = 72.4 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 40/182 (21%), Positives = 77/182 (42%), Gaps = 12/182 (6%) Query: 141 QLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGM 200 ++ E+P +P+ ELR ++ ++K F+G + +E+ N + IE F + Sbjct: 20 KVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEV-IEADVFSNL 78 Query: 201 KKLSYIRI-ADTNITTIPQGLP---PSLTELHLDGNKITKVDAASLKGLNNLAK--LGLS 254 KL IRI N+ I P+L L + I + + +++L K L + Sbjct: 79 PKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLP--DVHKIHSLQKVLLDIQ 136 Query: 255 FN-SISAVDNGSLANT-PHLRELHLNNNKLVKVPGGLADHKYIQVVYLH-NNNISAIGSN 311 N +I ++ S L LN N + ++ + + + L NNN+ + ++ Sbjct: 137 DNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNSAFNGTQLDELNLSDNNNLEELPND 196 Query: 312 DF 313 F Sbjct: 197 VF 198 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 24/136 (17%), Positives = 55/136 (40%), Gaps = 9/136 (6%) Query: 187 LKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPS---LTELHLDGNK-ITKVDAASL 242 + S + + +R T + I +G L ++ + N + ++A Sbjct: 16 CQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVF 75 Query: 243 KGLNNLAKLGLSF-NSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQV--VY 299 L L ++ + N++ ++ + N P+L+ L ++N + +P + +Q + Sbjct: 76 SNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD-VHKIHSLQKVLLD 134 Query: 300 LHNN-NISAIGSNDFC 314 + +N NI I N F Sbjct: 135 IQDNINIHTIERNSFV 150 >5GY2-A nrPDB Length = 455 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 70/310 (22%), Positives = 117/310 (37%), Gaps = 63/310 (20%) Query: 82 PDTALLDLQNNKITE--IKDGDFKNLKNLHTLILINNKISKISPGAF-APLVKLERLYLS 138 + +L L + + FK L +L L+L +N I KI P +F + + L L+ Sbjct: 103 ANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLT 162 Query: 139 KNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGT----NPLKSSGIE- 193 N++K + E+ L T +R S L M LG NP K++ I Sbjct: 163 FNKVKSICEE-----DLLNFQGKHFTLLRLSSIT-LQDMNEYWLGWEKCGNPFKNTSITT 216 Query: 194 -----NGAFQGMKKLSYIRIADTNITTIP------------------------QGLPPS- 223 NG + M K + IA T I ++ +GL S Sbjct: 217 LDLSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTNFKDPDNFTFKGLEASG 276 Query: 224 LTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLV 283 + L +KI + + +L +L L+ N I+ +D+ + HL +L+L+ N L Sbjct: 277 VKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLTHLLKLNLSQNFLG 336 Query: 284 KV-PGGLADHKYIQVVYLHNNNISAIGSNDF------------------CPPGYNTKKAS 324 + + ++V+ L N+I A+G F P G + S Sbjct: 337 SIDSRMFENLDKLEVLDLSYNHIRALGDQSFLGLPNLKELALDTNQLKSVPDGIFDRLTS 396 Query: 325 YSGVSLFSNP 334 + L +NP Sbjct: 397 LQKIWLHTNP 406 Score = 92.5 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 101/284 (35%), Gaps = 41/284 (14%) Query: 57 FRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINN 116 C C + GL +VP +LP +DL N I E+ + F L++L L Sbjct: 6 SECSVIGYNAICINRGLHQVP-ELPAHVNYVDLSLNSIAELNETSFSRLQDLQFL----- 59 Query: 117 KISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQ 176 K+ + +PG L + N + L +L L++ N+ ++ FNGL Sbjct: 60 KVEQQTPG----------LVIRNNTFRGLS-----SLIILKLDYNQFLQLETGAFNGLAN 104 Query: 177 MIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLT----ELHLDGN 232 + V+ L L + + F+ + L + + D NI I L L N Sbjct: 105 LEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFN 164 Query: 233 KITKVDAASLKGLNN--LAKLGLSFNSISAVDNGSLAN--------TPHLRELHLNNNKL 282 K+ + L L LS ++ ++ L + L L+ N Sbjct: 165 KVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGF 224 Query: 283 V-KVPGGLADH---KYIQVVYLHN--NNISAIGSNDFCPPGYNT 320 + D IQ + L N N S+ G +F P T Sbjct: 225 KESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTNFKDPDNFT 268 >2Z80-A nrPDB Length = 353 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 73/298 (24%), Positives = 111/298 (37%), Gaps = 56/298 (18%) Query: 69 SDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAP 128 S L +P L LDL NN+IT I + D + NL L+L +N I+ I +F+ Sbjct: 39 SSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSS 98 Query: 129 LVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLK 188 L LE L LS N L L S F L+ + + L NP K Sbjct: 99 LGSLEHLDLSYNYLSNLS---------------------SSWFKPLSSLTFLNLLGNPYK 137 Query: 189 SSGIENGAFQGMKKLSYIRIADTNITTIPQ----GLPPSLTELHLDGNKITKVDAASLKG 244 + G E F + KL +R+ + + T Q L EL +D + + + SLK Sbjct: 138 TLG-ETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKS 196 Query: 245 LNNLAKLGLSFNSISAVDNGSLANTPH------LRELHLNNNKLVKVPGG---------- 288 + N++ L L + + LR+ L+ ++ G Sbjct: 197 IQNVSHLIL-HMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFT 255 Query: 289 -----LADHKYIQVVYLHNNNISAIGSNDF-------CPPGYNTKKASYSGVSLFSNP 334 + D QV+ L N IS + +F P G + S + L +NP Sbjct: 256 FRNVKITDESLFQVMKL-LNQISGLLELEFSRNQLKSVPDGIFDRLTSLQKIWLHTNP 312 Score = 79.0 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 26/127 (20%), Positives = 51/127 (40%), Gaps = 1/127 (0%) Query: 207 RIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSL 266 + + ++ +IP GL ++ L L N+IT + + L+ NL L L+ N I+ ++ S Sbjct: 37 KGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSF 96 Query: 267 ANTPHLRELHLNNNKLVKVPGGLA-DHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASY 325 ++ L L L+ N L + + + L N +G + Sbjct: 97 SSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRV 156 Query: 326 SGVSLFS 332 + F+ Sbjct: 157 GNMDTFT 163 >2Z7X-A nrPDB Length = 549 Score = 110 bits (276), Expect = 6e-25, Method: Composition-based stats. Identities = 55/189 (29%), Positives = 80/189 (42%), Gaps = 26/189 (13%) Query: 69 SDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAP 128 S L +P L LDL NN+IT I + D + NL L+L +N I+ I +F+ Sbjct: 13 SSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSS 72 Query: 129 LVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLK 188 L LE L LS N L L S F L+ + + L NP K Sbjct: 73 LGSLEHLDLSYNYLSNLS---------------------SSWFKPLSSLTFLNLLGNPYK 111 Query: 189 SSGIENGAFQGMKKLSYIRIADTNITTIPQ----GLPPSLTELHLDGNKITKVDAASLKG 244 + G E F + KL +R+ + + T Q L EL +D + + + SLK Sbjct: 112 TLG-ETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKS 170 Query: 245 LNNLAKLGL 253 + N++ L L Sbjct: 171 IQNVSHLIL 179 Score = 78.2 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 26/127 (20%), Positives = 51/127 (40%), Gaps = 1/127 (0%) Query: 207 RIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSL 266 + + ++ +IP GL ++ L L N+IT + + L+ NL L L+ N I+ ++ S Sbjct: 11 KGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSF 70 Query: 267 ANTPHLRELHLNNNKLVKVPGGLA-DHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASY 325 ++ L L L+ N L + + + L N +G + Sbjct: 71 SSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRV 130 Query: 326 SGVSLFS 332 + F+ Sbjct: 131 GNMDTFT 137 Score = 71.3 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 51/236 (21%), Positives = 90/236 (38%), Gaps = 42/236 (17%) Query: 81 PPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAF-------APLVKLE 133 P L ++ I F +L L++L +I+ + F L LE Sbjct: 280 PGKVETLTIRRLHIPRFY--LFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLE 337 Query: 134 RLYLSKNQLKE------LPEKMPKTLQELRVHENEITKVRK--SVFNGLNQMIVVELGTN 185 L LS+N + E E +LQ L + +N + + K L + +++ N Sbjct: 338 YLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKN 397 Query: 186 PLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLP--------------------PSLT 225 S Q +K+ Y+ ++ T I ++ +P P L Sbjct: 398 SFHSM---PETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLK 454 Query: 226 ELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNK 281 EL++ NK+ + ASL L L L +S N + +V +G L+++ L+ N Sbjct: 455 ELYISRNKLMTLPDASL--LPMLLVLKISRNQLKSVPDGIFDRLTSLQKIWLHTNP 508 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 15/55 (27%), Positives = 25/55 (45%), Gaps = 1/55 (1%) Query: 63 LRVVQCSDLGLEKVPK-DLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINN 116 L+ + S L +P L P +L + N++ + DG F L +L + L N Sbjct: 453 LKELYISRNKLMTLPDASLLPMLLVLKISRNQLKSVPDGIFDRLTSLQKIWLHTN 507 >3A7C-A nrPDB Length = 580 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 61/229 (26%), Positives = 90/229 (39%), Gaps = 42/229 (18%) Query: 70 DLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPL 129 +P L LDL NKIT I GD + NL LIL +++I+ I AF L Sbjct: 40 SRSFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSL 99 Query: 130 VKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKS 189 LE L LS N L L S F L+ + + L NP ++ Sbjct: 100 GSLEHLDLSDNHLSSLS---------------------SSWFGPLSSLKYLNLMGNPYQT 138 Query: 190 SGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLA 249 G+ F + L +RI N+ T ++I ++D A L LN L Sbjct: 139 LGV-TSLFPNLTNLQTLRIG--NVETF---------------SEIRRIDFAGLTSLNELE 180 Query: 250 KLGLSFNSISAVDNGSLANTPHLRELHLNNNK--LVKVPGGLADHKYIQ 296 LS + + S+ + HL LHL+ + L L+ +Y++ Sbjct: 181 IKALSLRNYQSQSLKSIRDIHHL-TLHLSESAFLLEIFADILSSVRYLE 228 Score = 86.3 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 45/199 (22%), Positives = 86/199 (43%), Gaps = 19/199 (9%) Query: 116 NKISKISPGAF-APLVKLERLYLSKNQLKE------LPEKMPKTLQELRVHENEITKVRK 168 N + P +F L LE L LS+N + E + +LQ L + +N + ++K Sbjct: 345 NSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQK 404 Query: 169 --SVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTE 226 + L + +++ N + Q +K+ ++ ++ T I + +P +L Sbjct: 405 TGEILLTLKNLTSLDISRNTFH---PMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQTLEV 461 Query: 227 LHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVP 286 L + N + L L +L +S N + + + SL P L + + +N+L VP Sbjct: 462 LDVSNNNLDSFSLF----LPRLQELYISRNKLKTLPDASL--FPVLLVMKIASNQLKSVP 515 Query: 287 GGLAD-HKYIQVVYLHNNN 304 G+ D +Q ++LH N Sbjct: 516 DGIFDRLTSLQKIWLHTNP 534 Score = 85.9 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 30/127 (23%), Positives = 50/127 (39%), Gaps = 1/127 (0%) Query: 207 RIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSL 266 + T+IP GL ++ L L NKIT + L+ NL L L + I+ ++ + Sbjct: 37 DGRSRSFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAF 96 Query: 267 ANTPHLRELHLNNNKLVKVPGGLA-DHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASY 325 + L L L++N L + ++ + L N +G P N + Sbjct: 97 YSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRI 156 Query: 326 SGVSLFS 332 V FS Sbjct: 157 GNVETFS 163 Score = 63.2 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 34/184 (18%), Positives = 69/184 (37%), Gaps = 15/184 (8%) Query: 148 KMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGM-KKLSYI 206 + + ++ + V +++ V S L + ++L N + ++N A +G L + Sbjct: 333 SLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTL 392 Query: 207 RIADTNITTIPQG-----LPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAV 261 ++ ++ ++ + +LT L + N + S + + L LS I V Sbjct: 393 VLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMP-DSCQWPEKMRFLNLSSTGIRVV 451 Query: 262 DNGSLANTPH-LRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNT 320 P L L ++NN L L +Q +Y+ N + + P Sbjct: 452 K----TCIPQTLEVLDVSNNNLDSFSLFLP---RLQELYISRNKLKTLPDASLFPVLLVM 504 Query: 321 KKAS 324 K AS Sbjct: 505 KIAS 508 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 49/285 (17%), Positives = 100/285 (35%), Gaps = 27/285 (9%) Query: 62 HLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLK------NLHTLILIN 115 HL + L ++ D+ L+L++ + + F L + L Sbjct: 202 HLTLHLSESAFLLEIFADILSSVRYLELRDTNLARFQ---FSPLPVDEVSSPMKKLAFRG 258 Query: 116 NKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLN 175 S ++ +F L+KL R L L E+ TL L + V + Sbjct: 259 ---SVLTDESFNELLKLLRYILE---LSEVEFDDC-TLNGLGDFNPSESDVVSE-LGKVE 310 Query: 176 QMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPP---SLTELHLDGN 232 + + L + + ++K+ I + ++ + +P SL L L N Sbjct: 311 TVTIRRLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSEN 370 Query: 233 KITK--VDAASLKGL-NNLAKLGLSFNSISAVDNGS--LANTPHLRELHLNNNKLVKVPG 287 + + + ++ KG +L L LS N + ++ L +L L ++ N +P Sbjct: 371 LMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPD 430 Query: 288 GLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFS 332 + ++ + L + I + + P S + + FS Sbjct: 431 SCQWPEKMRFLNLSSTGIRVVKTC--IPQTLEVLDVSNNNLDSFS 473 Score = 37.0 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 27/55 (49%), Gaps = 1/55 (1%) Query: 63 LRVVQCSDLGLEKVPK-DLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINN 116 L+ + S L+ +P L P ++ + +N++ + DG F L +L + L N Sbjct: 479 LQELYISRNKLKTLPDASLFPVLLVMKIASNQLKSVPDGIFDRLTSLQKIWLHTN 533 >5D3I-A nrPDB Length = 568 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 61/229 (26%), Positives = 90/229 (39%), Gaps = 42/229 (18%) Query: 70 DLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPL 129 +P L LDL NKIT I GD + NL LIL +++I+ I AF L Sbjct: 18 SRSFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSL 77 Query: 130 VKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKS 189 LE L LS N L L S F L+ + + L NP ++ Sbjct: 78 GSLEHLDLSDNHLSSLS---------------------SSWFGPLSSLKYLNLMGNPYQT 116 Query: 190 SGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLA 249 G+ F + L +RI N+ T ++I ++D A L LN L Sbjct: 117 LGV-TSLFPNLTNLQTLRIG--NVETF---------------SEIRRIDFAGLTSLNELE 158 Query: 250 KLGLSFNSISAVDNGSLANTPHLRELHLNNNK--LVKVPGGLADHKYIQ 296 LS + + S+ + HL LHL+ + L L+ +Y++ Sbjct: 159 IKALSLRNYQSQSLKSIRDIHHL-TLHLSESAFLLEIFADILSSVRYLE 206 Score = 85.5 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 30/127 (23%), Positives = 50/127 (39%), Gaps = 1/127 (0%) Query: 207 RIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSL 266 + T+IP GL ++ L L NKIT + L+ NL L L + I+ ++ + Sbjct: 15 DGRSRSFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAF 74 Query: 267 ANTPHLRELHLNNNKLVKVPGGLA-DHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASY 325 + L L L++N L + ++ + L N +G P N + Sbjct: 75 YSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRI 134 Query: 326 SGVSLFS 332 V FS Sbjct: 135 GNVETFS 141 Score = 65.9 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 38/200 (19%), Positives = 79/200 (39%), Gaps = 19/200 (9%) Query: 116 NKISKISPGAF-APLVKLERLYLSKNQLKE------LPEKMPKTLQELRVHENEITKVRK 168 N + P +F L LE L LS+N + E + +LQ L + +N + ++K Sbjct: 323 NSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQK 382 Query: 169 --SVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTE 226 + L + +++ N + Q +K+ ++ ++ T I + +P +L Sbjct: 383 TGEILLTLKNLTSLDISRNTFH---PMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQTLEV 439 Query: 227 LHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVP 286 L + N + L L +L +S N + + + SL P L + + N + Sbjct: 440 LDVSNNNLDSFSLF----LPRLQELYISRNKLKTLPDASL--FPVLLVMKIRENAVSTFS 493 Query: 287 -GGLADHKYIQVVYLHNNNI 305 L ++ + +N+ Sbjct: 494 KDQLGSFPKLETLEAGDNHF 513 Score = 64.0 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 36/192 (18%), Positives = 72/192 (37%), Gaps = 16/192 (8%) Query: 148 KMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGM-KKLSYI 206 + + ++ + V +++ V S L + ++L N + ++N A +G L + Sbjct: 311 SLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTL 370 Query: 207 RIADTNITTIPQG-----LPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAV 261 ++ ++ ++ + +LT L + N + S + + L LS I V Sbjct: 371 VLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMP-DSCQWPEKMRFLNLSSTGIRVV 429 Query: 262 DNGSLANTPH-LRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNT 320 P L L ++NN L L +Q +Y+ N + + P Sbjct: 430 K----TCIPQTLEVLDVSNNNLDSFSLFLP---RLQELYISRNKLKTLPDASLFPVLL-V 481 Query: 321 KKASYSGVSLFS 332 K + VS FS Sbjct: 482 MKIRENAVSTFS 493 Score = 42.0 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 49/285 (17%), Positives = 100/285 (35%), Gaps = 27/285 (9%) Query: 62 HLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLK------NLHTLILIN 115 HL + L ++ D+ L+L++ + + F L + L Sbjct: 180 HLTLHLSESAFLLEIFADILSSVRYLELRDTNLARFQ---FSPLPVDEVSSPMKKLAFRG 236 Query: 116 NKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLN 175 S ++ +F L+KL R L L E+ TL L + V + Sbjct: 237 ---SVLTDESFNELLKLLRYILE---LSEVEFDDC-TLNGLGDFNPSESDVVSE-LGKVE 288 Query: 176 QMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPP---SLTELHLDGN 232 + + L + + ++K+ I + ++ + +P SL L L N Sbjct: 289 TVTIRRLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSEN 348 Query: 233 KITK--VDAASLKGL-NNLAKLGLSFNSISAVDNGS--LANTPHLRELHLNNNKLVKVPG 287 + + + ++ KG +L L LS N + ++ L +L L ++ N +P Sbjct: 349 LMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPD 408 Query: 288 GLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFS 332 + ++ + L + I + + P S + + FS Sbjct: 409 SCQWPEKMRFLNLSSTGIRVVKTC--IPQTLEVLDVSNNNLDSFS 451 >3G06-A nrPDB Length = 622 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 63/274 (22%), Positives = 109/274 (39%), Gaps = 50/274 (18%) Query: 65 VVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKIS-- 122 V+ + GL +P LP L + +N +T + L TL + N+++ + Sbjct: 44 VLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTSLPVL 99 Query: 123 -PGAFA------PLVKL-------ERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRK 168 PG PL L +L++ NQL LP +P LQEL V +N++ + Sbjct: 100 PPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLP-VLPPGLQELSVSDNQLASLPA 158 Query: 169 SVFNGLNQMIVVELGTNPLKSSGIENGAFQGMK--------------KLSYIRIADTNIT 214 +++ + N L S + Q + +L + + +T Sbjct: 159 LP----SELCKLWAYNNQLTSLPMLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLT 214 Query: 215 TIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH-LR 273 ++P LP L EL + GN++T + + L +L +S N ++ SL P L Sbjct: 215 SLP-ALPSGLKELIVSGNRLTSLPVLP----SELKELMVSGNRLT-----SLPMLPSGLL 264 Query: 274 ELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISA 307 L + N+L ++P L V L N +S Sbjct: 265 SLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSE 298 Score = 74.0 bits (180), Expect = 9e-14, Method: Composition-based stats. Identities = 44/221 (19%), Positives = 86/221 (38%), Gaps = 28/221 (12%) Query: 134 RLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIE 193 L + ++ L LP+ +P + L + +N +T + ++ +E+ N L S + Sbjct: 44 VLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTSLPVL 99 Query: 194 NGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGL 253 L + I +T +P LP L +L + GN++T + L +L + Sbjct: 100 P------PGLLELSIFSNPLTHLP-ALPSGLCKLWIFGNQLTSLPVLP----PGLQELSV 148 Query: 254 SFNSISAVDNGSLANTPH-LRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSND 312 S N + SL P L +L NN+L +P + + + V ++ + S Sbjct: 149 SDNQL-----ASLPALPSELCKLWAYNNQLTSLPMLPSGLQELSVSDNQLASLPTLPSEL 203 Query: 313 FCPPGYNTKKAS-------YSGVSLFSNPVQYWEIQPSTFR 346 + YN + S + + N + + PS + Sbjct: 204 YKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLPSELK 244 >1JL5-A nrPDB Length = 454 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 59/258 (22%), Positives = 110/258 (42%), Gaps = 41/258 (15%) Query: 57 FRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINN 116 + L+++ + L+K+P DLPP + NN++ E+ + +NL L + NN Sbjct: 149 LQNSSFLKIIDVDNNSLKKLP-DLPPSLEFIAAGNNQLEELPE--LQNLPFLTAIYADNN 205 Query: 117 KISKISP------------------GAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRV 158 + K+ L L +Y N LK LP+ +P +L+ L V Sbjct: 206 SLKKLPDLPLSLESIVAGNNILEELPELQNLPFLTTIYADNNLLKTLPD-LPPSLEALNV 264 Query: 159 HENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQ 218 +N +T + + + +++ N I +G + L Y+ + I ++ Sbjct: 265 RDNYLTDLPELP----QSLTFLDVSEN------IFSGLSELPPNLYYLNASSNEIRSL-C 313 Query: 219 GLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLN 278 LPPSL EL++ NK+ ++ A L +L SFN ++ V +L++LH+ Sbjct: 314 DLPPSLEELNVSNNKLIELPALP----PRLERLIASFNHLAEVPELPQ----NLKQLHVE 365 Query: 279 NNKLVKVPGGLADHKYIQ 296 N L + P + ++ Sbjct: 366 YNPLREFPDIPESVEDLR 383 Score = 77.4 bits (189), Expect = 9e-15, Method: Composition-based stats. Identities = 55/274 (20%), Positives = 111/274 (40%), Gaps = 50/274 (18%) Query: 69 SDLGLEKVPKDLPPDTALLDLQNNKITEIKD------------GDFKNLKN----LHTLI 112 ++LGL +P +LPP L N +TE+ + + K L + L L Sbjct: 79 NNLGLSSLP-ELPPHLESLVASCNSLTELPELPQSLKSLLVDNNNLKALSDLPPLLEYLG 137 Query: 113 LINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFN 172 + NN++ K+ L+ + + N LK+LP+ +P +L+ + N++ ++ + Sbjct: 138 VSNNQLEKLPE--LQNSSFLKIIDVDNNSLKKLPD-LPPSLEFIAAGNNQLEELPE--LQ 192 Query: 173 GLNQMIVVELGTNPLKSSGIENGA----------------FQGMKKLSYIRIADTNITTI 216 L + + N LK + Q + L+ I + + T+ Sbjct: 193 NLPFLTAIYADNNSLKKLPDLPLSLESIVAGNNILEELPELQNLPFLTTIYADNNLLKTL 252 Query: 217 PQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELH 276 P LPPSL L++ N +T + +L L +S N S + P+L L+ Sbjct: 253 P-DLPPSLEALNVRDNYLTDLPELP----QSLTFLDVSENIFSGLSELP----PNLYYLN 303 Query: 277 LNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGS 310 ++N++ + ++ + + NN + + + Sbjct: 304 ASSNEIRSL---CDLPPSLEELNVSNNKLIELPA 334 Score = 64.3 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 44/216 (20%), Positives = 86/216 (39%), Gaps = 17/216 (7%) Query: 130 VKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKS 189 LE L S N L ELPE +P++L+ L V N + + + + + N L+ Sbjct: 91 PHLESLVASCNSLTELPE-LPQSLKSLLVDNNNLKALSDLPPL----LEYLGVSNNQLEK 145 Query: 190 SGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLA 249 Q L I + + ++ +P LPPSL + N++ ++ L+ L L Sbjct: 146 LP----ELQNSSFLKIIDVDNNSLKKLP-DLPPSLEFIAAGNNQLEELPE--LQNLPFLT 198 Query: 250 KLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIG 309 + NS+ + + L L + NN L ++P L + ++ +Y NN + + Sbjct: 199 AIYADNNSLKKLPDLPL----SLESIVAGNNILEELPE-LQNLPFLTTIYADNNLLKTLP 253 Query: 310 SNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPSTF 345 N + + + + + ++ + F Sbjct: 254 DLPPSLEALNVRDNYLTDLPELPQSLTFLDVSENIF 289 >6HKW-A nrPDB Length = 363 Score = 107 bits (267), Expect = 7e-24, Method: Composition-based stats. Identities = 60/254 (23%), Positives = 118/254 (46%), Gaps = 17/254 (6%) Query: 83 DTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQL 142 L L+ N I I++ + L++L L L +N+I KI L +LE L +S N L Sbjct: 102 KVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKIEN--LEALTELEILDISFNLL 157 Query: 143 KELPE-KMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMK 201 + + L++L + N+I+K+ + L+Q+ ++ELG+N +++ + Sbjct: 158 RNIEGVDKLTRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAIEN----IDTLT 211 Query: 202 KLSYIRIADTNITTIPQ-GLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISA 260 L + + IT + +LT L + N++TK++ L+ L NL +L LS N I Sbjct: 212 NLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIE--GLQNLVNLRELYLSHNGIEV 269 Query: 261 VDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNT 320 ++ L N L L + +N++ K+ ++ +Q ++++N + + D + Sbjct: 270 IE--GLENNNKLTMLDIASNRIKKI-ENISHLTELQEFWMNDNLLESWSDLDELKGARSL 326 Query: 321 KKASYSGVSLFSNP 334 + L +P Sbjct: 327 ETVYLERNPLQKDP 340 Score = 50.9 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 53/137 (38%), Gaps = 28/137 (20%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 + +L +Q+N++T+I +NL NL L L +N I I KL L ++ N+ Sbjct: 233 TNLTVLSMQSNRLTKI--EGLQNLVNLRELYLSHNGIEVIE--GLENNNKLTMLDIASNR 288 Query: 142 LKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMK 201 +K++ + L ++ + N L+S + +G + Sbjct: 289 IKKI-----------------------ENISHLTELQEFWMNDNLLESWSDLDE-LKGAR 324 Query: 202 KLSYIRIADTNITTIPQ 218 L + + + PQ Sbjct: 325 SLETVYLERNPLQKDPQ 341 Score = 34.7 bits (78), Expect = 0.060, Method: Composition-based stats. Identities = 18/76 (23%), Positives = 35/76 (46%), Gaps = 3/76 (3%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKI-SKISPGAFAPLVKLERLYLSKN 140 +LD+ +N+I +I++ +L L + +N + S LE +YL +N Sbjct: 277 NKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERN 334 Query: 141 QLKELPEKMPKTLQEL 156 L++ P+ K + L Sbjct: 335 PLQKDPQYRRKVMLAL 350 >1XWD-C nrPDB Length = 252 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 107/265 (40%), Gaps = 57/265 (21%) Query: 55 CPFR-CQCHLRVVQCSDLGLEKVPKDLPP------------------------DTALLDL 89 C R C C RV C + + ++P DLP D +++ Sbjct: 2 CHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEI 61 Query: 90 QNNKITEIKDGD-FKNLKNLHTLIL-INNKISKISPGAFAPLVKLERLYLSKNQLKELPE 147 N + E+ + D F NL LH + + N + I+P AF L L+ L +S +K LP+ Sbjct: 62 SQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD 121 Query: 148 -KMPKTLQE--LRVHEN-EITKVRKSVFNGLN-QMIVVELGTNPLKSSGIENGAFQGMKK 202 +LQ+ L + +N I + ++ F GL+ + +++ L N ++ I N AF G + Sbjct: 122 VHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQE--IHNCAFNG-TQ 178 Query: 203 LSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVD 262 L + ++D N + ++ G + L +S I ++ Sbjct: 179 LDELNLSDN--------------------NNLEELPNDVFHGASGPVILDISRTRIHSLP 218 Query: 263 NGSLANTPHLRELHLNNNKLVKVPG 287 + L N LR + L K+P Sbjct: 219 SYGLENLKKLR--ARSTYNLKKLPT 241 Score = 66.3 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 38/180 (21%), Positives = 71/180 (39%), Gaps = 8/180 (4%) Query: 141 QLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGM 200 ++ E+P +P+ ELR ++ ++K F+G + +E+ N + IE F + Sbjct: 20 KVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEV-IEADVFSNL 78 Query: 201 KKLSYIRI-ADTNITTIPQGLP---PSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFN 256 KL IRI N+ I P+L L + I + L + N Sbjct: 79 PKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDN 138 Query: 257 -SISAVDNGSLANT-PHLRELHLNNNKLVKVPGGLADHKYIQVVYLH-NNNISAIGSNDF 313 +I ++ S L LN N + ++ + + + L NNN+ + ++ F Sbjct: 139 INIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVF 198 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 24/136 (17%), Positives = 55/136 (40%), Gaps = 9/136 (6%) Query: 187 LKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPS---LTELHLDGNK-ITKVDAASL 242 + S + + +R T + I +G L ++ + N + ++A Sbjct: 16 CQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVF 75 Query: 243 KGLNNLAKLGLSF-NSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQV--VY 299 L L ++ + N++ ++ + N P+L+ L ++N + +P + +Q + Sbjct: 76 SNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPD-VHKIHSLQKVLLD 134 Query: 300 LHNN-NISAIGSNDFC 314 + +N NI I N F Sbjct: 135 IQDNINIHTIERNSFV 150 >3G04-C nrPDB Length = 239 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 59/242 (24%), Positives = 109/242 (45%), Gaps = 33/242 (13%) Query: 59 CQCHLR---VVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILI- 114 C+CH V C D+ +++P LPP T L L + I F NL N+ + + Sbjct: 8 CECHQEEDFRVTCKDI--QRIPS-LPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSI 64 Query: 115 NNKISKISPGAFAPLVKLERL---------YLSKNQLKELPEKMPKTLQELRVHENEITK 165 + + ++ +F L K+ + Y+ + LKELP L+ L + + Sbjct: 65 DVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPL-----LKFLGIFNTGLKM 119 Query: 166 VRK-SVFNGLNQMIVVELGTNPLKSSGIENGAFQGM-KKLSYIRIADTNITTIPQGLPPS 223 + + ++E+ NP +S I AFQG+ + +++ + T++ QG + Sbjct: 120 FPDLTKVYSTDIFFILEITDNPYMTS-IPVNAFQGLCNETLTLKLYNNGFTSV-QGYAFN 177 Query: 224 LTELH---LDGNK-ITKVDAASLKGL-NNLAKLGLSFNSISAVDNGSLANTPHLRELHLN 278 T+L L+ NK +T +D + G+ + + L +S S++A+ + L HL+EL Sbjct: 178 GTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLE---HLKELIAR 234 Query: 279 NN 280 N Sbjct: 235 NT 236 >5KH1-A nrPDB Length = 591 Score = 87.8 bits (216), Expect = 7e-18, Method: Composition-based stats. Identities = 44/245 (17%), Positives = 100/245 (40%), Gaps = 30/245 (12%) Query: 70 DLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPL 129 D+ +++ L LDL +T + + + ++ + N +S ISP Sbjct: 55 DIAFQRLVSCLQNQETNLDLSELGLTTLPEIP----PGIKSINISKNNLSLISPLP---- 106 Query: 130 VKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKS 189 L +L +S N+L ELP +P+ L+ L N++ + + + + + N L S Sbjct: 107 ASLTQLNVSYNRLIELP-ALPQGLKLLNASHNQLITLPTLPIS----LKELHVSNNQLCS 161 Query: 190 SGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLA 249 + L + ++ + +P LP SL E+ GN ++++ +N+ Sbjct: 162 LPVLPEL------LETLDVSCNGLAVLPP-LPFSLQEISAIGNLLSELPPLP----HNIH 210 Query: 250 KLGLSFNSISAVDNGSLANTP-HLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAI 308 + N ++ + P +LR + + N++ +P + + + + + +N +S+ Sbjct: 211 SIWAIDNMLTDIP-----YLPENLRNGYFDINQISHIPESILNLRNECSIDISDNPLSSH 265 Query: 309 GSNDF 313 Sbjct: 266 ALQSL 270 >4ECN-A nrPDB Length = 876 Score = 82.5 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 65/334 (19%), Positives = 122/334 (36%), Gaps = 47/334 (14%) Query: 29 LEDEASGIGPEEHFPEVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLP----PDT 84 S + + + + E GP +++ LE+ P Sbjct: 524 CNRGISAAQLKADWTRLADDEDTGPK--------IQIFYMGYNNLEEFPASASLQKMVKL 575 Query: 85 ALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKE 144 LLD +NK+ + F L L L N+I +I A ++E L S N+LK Sbjct: 576 GLLDCVHNKVRHL--EAFGTNVKLTDLKLDYNQIEEIPEDFCAFTDQVEGLGFSHNKLKY 633 Query: 145 LPEKMPK----TLQELRVHENEITKVRKSVFNGLN-----QMIVVELGTNPLKSSGIENG 195 +P + + N+I +++ ++ V L N ++ E Sbjct: 634 IPNIFNAKSVYVMGSVDFSYNKIGSEGRNISCSMDDYKGINASTVTLSYNEIQKFPTE-- 691 Query: 196 AFQGMKKLSYIRIADTNITTIPQ-GLPPS---------LTELHLDGNKITKVDAASLKG- 244 F +S I +++ +T+IP+ L P LT + L NK+T + + + Sbjct: 692 LFATGSPISTIILSNNLMTSIPENSLKPKDGNYKNTYLLTTIDLRFNKLTSL-SDDFRAT 750 Query: 245 -LNNLAKLGLSFNSISAVDNGSLANTPHLREL------HLNNNK-LVKVPGGLADHKYIQ 296 L L+ + +S+N S+ L N+ L+ N+ L + P G+ + Sbjct: 751 TLPYLSNMDVSYNCFSSFPTQPL-NSSQLKAFGIRHQRDAEGNRILRQWPTGITTCPSLI 809 Query: 297 VVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSL 330 + + +N+I + P Y A +S+ Sbjct: 810 QLQIGSNDIRKVDEK-LTPQLYILDIADNPNISI 842 Score = 70.9 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 45/262 (17%), Positives = 95/262 (36%), Gaps = 40/262 (15%) Query: 88 DLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKN------- 140 +L + + ++ D + N N+ L P L +L+ L ++ N Sbjct: 484 ELSWSNLKDLTDVELYNCPNMTQL-----------PDFLYDLPELQSLNIACNRGISAAQ 532 Query: 141 ------QLKELPEKMPKTLQELRVHENEITKVRKS-VFNGLNQMIVVELGTNPLKSSGIE 193 +L + + PK +Q + N + + S + ++ +++ N ++ Sbjct: 533 LKADWTRLADDEDTGPK-IQIFYMGYNNLEEFPASASLQKMVKLGLLDCVHNKVR----H 587 Query: 194 NGAFQGMKKLSYIRIADTNITTIPQG---LPPSLTELHLDGNKITKVDAA-SLKGLNNLA 249 AF KL+ +++ I IP+ + L NK+ + + K + + Sbjct: 588 LEAFGTNVKLTDLKLDYNQIEEIPEDFCAFTDQVEGLGFSHNKLKYIPNIFNAKSVYVMG 647 Query: 250 KLGLSFNSISAVDNGSLANTP-----HLRELHLNNNKLVKVPGGLADHKY-IQVVYLHNN 303 + S+N I + + + + L+ N++ K P L I + L NN Sbjct: 648 SVDFSYNKIGSEGRNISCSMDDYKGINASTVTLSYNEIQKFPTELFATGSPISTIILSNN 707 Query: 304 NISAIGSNDFCPPGYNTKKASY 325 +++I N P N K Sbjct: 708 LMTSIPENSLKPKDGNYKNTYL 729 >3CVR-A nrPDB Length = 571 Score = 80.1 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 46/245 (18%), Positives = 86/245 (35%), Gaps = 67/245 (27%) Query: 66 VQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGA 125 +Q + L L +P +LPP +L++ N + + + Sbjct: 64 LQLNRLNLSSLPDNLPPQITVLEITQNALISLPELP------------------------ 99 Query: 126 FAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTN 185 LE L N+L LPE +P +L+ L V N++T + L + Sbjct: 100 ----ASLEYLDACDNRLSTLPE-LPASLKHLDVDNNQLTMLP-----ELPAL-------- 141 Query: 186 PLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGL 245 L YI + +T +P+ LP SL L + N++T + Sbjct: 142 -----------------LEYINADNNQLTMLPE-LPTSLEVLSVRNNQLTFLPELP---- 179 Query: 246 NNLAKLGLSFNSISAVDNGSLANTPHLRE---LHLNNNKLVKVPGGLADHKYIQVVYLHN 302 +L L +S N + ++ + N N++ +P + + L + Sbjct: 180 ESLEALDVSTNLLESLPAVPVRNHHSEETEIFFRCRENRITHIPENILSLDPTCTIILED 239 Query: 303 NNISA 307 N +S+ Sbjct: 240 NPLSS 244 Score = 55.1 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 31/169 (18%), Positives = 61/169 (36%), Gaps = 23/169 (13%) Query: 200 MKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSIS 259 + + S +++ N++++P LPP +T L + N + + +L L N +S Sbjct: 58 INQFSELQLNRLNLSSLPDNLPPQITVLEITQNALISLPELP----ASLEYLDACDNRLS 113 Query: 260 ------------AVDNGSLANTPH----LRELHLNNNKLVKVPGGLADHKYIQVVYLHNN 303 VDN L P L ++ +NN+L +P ++V+ + NN Sbjct: 114 TLPELPASLKHLDVDNNQLTMLPELPALLEYINADNNQLTMLP---ELPTSLEVLSVRNN 170 Query: 304 NISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRA 352 ++ + + + + E FRC R Sbjct: 171 QLTFLPELPESLEALDVSTNLLESLPAVPVRNHHSEETEIFFRCRENRI 219 >1M9S-A nrPDB Length = 605 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 45/207 (21%), Positives = 79/207 (38%), Gaps = 18/207 (8%) Query: 69 SDLGLEKVPKDLPPD----TALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPG 124 +L + V + + + N+ I ++ + L N+ L L NK++ I P Sbjct: 26 DNLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQG--IQYLPNVTKLFLNGNKLTDIKP- 82 Query: 125 AFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVH-ENEITKVRKSVFNGLNQMIVVELG 183 L L L+L +N++K+L + N I+ + + L Q+ + LG Sbjct: 83 -LTNLKNLGWLFLDENKIKDLSSLKDLKKLKSLSLEHNGISDI--NGLVHLPQLESLYLG 139 Query: 184 TNPLKSSGIENGAFQGMKKLSYIRIADTNITTI-PQGLPPSLTELHLDGNKITKVDAASL 242 N + + + KL + + D I+ I P L L+L N I+ + +L Sbjct: 140 NNKITDITV----LSRLTKLDTLSLEDNQISDIVPLAGLTKLQNLYLSKNHISDL--RAL 193 Query: 243 KGLNNLAKLGLSFNSISAVDNGSLANT 269 GL NL L L +N Sbjct: 194 AGLKNLDVLELFSQECLNKPINHQSNL 220 Score = 72.1 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 31/157 (19%), Positives = 57/157 (36%), Gaps = 18/157 (11%) Query: 161 NEITKVRKSV--------FNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTN 212 N I ++ + L + + L N L +K L ++ + + Sbjct: 43 NSIDQIIANNSDIKSVQGIQYLPNVTKLFLNGNKLTDIK----PLTNLKNLGWLFLDENK 98 Query: 213 ITTIPQGLPPSLTELHL-DGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH 271 I + + + N I+ + L L L L L N I+ + L+ Sbjct: 99 IKDLSSLKDLKKLKSLSLEHNGISDI--NGLVHLPQLESLYLGNNKITDI--TVLSRLTK 154 Query: 272 LRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAI 308 L L L +N++ + LA +Q +YL N+IS + Sbjct: 155 LDTLSLEDNQISDI-VPLAGLTKLQNLYLSKNHISDL 190 Score = 67.8 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 36/105 (34%), Positives = 47/105 (44%), Gaps = 8/105 (7%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 P L L NNKIT+I L L TL L +N+IS I P A L KL+ LYLSKN Sbjct: 131 PQLESLYLGNNKITDI--TVLSRLTKLDTLSLEDNQISDIVP--LAGLTKLQNLYLSKNH 186 Query: 142 LKEL-PEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTN 185 + +L K L L + + N + ++V N Sbjct: 187 ISDLRALAGLKNLDVLELFS---QECLNKPINHQSNLVVPNTVKN 228 Score = 61.3 bits (147), Expect = 6e-10, Method: Composition-based stats. Identities = 38/171 (22%), Positives = 64/171 (37%), Gaps = 33/171 (19%) Query: 187 LKSSGIENGAFQG-MKKLSYIRIADTNITTIPQ-GLPPSLTELHLDGNKITKVDAASLKG 244 LK + + Q + + I +++I ++ P++T+L L+GNK+T + L Sbjct: 28 LKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVTKLFLNGNKLTDI--KPLTN 85 Query: 245 LNNLAKLGLSFNSISAV--------------------DNGSLANTPHLRELHLNNNKLVK 284 L NL L L N I + D L + P L L+L NNK+ Sbjct: 86 LKNLGWLFLDENKIKDLSSLKDLKKLKSLSLEHNGISDINGLVHLPQLESLYLGNNKITD 145 Query: 285 VPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPV 335 + L+ + + L +N IS I + L N + Sbjct: 146 I-TVLSRLTKLDTLSLEDNQISDIVPLA--------GLTKLQNLYLSKNHI 187 >1OGQ-A nrPDB Length = 313 Score = 79.4 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 54/254 (21%), Positives = 102/254 (40%), Gaps = 18/254 (7%) Query: 83 DTALLDLQNNKIT--EIKDGDFKNLKNLHTLILIN-NKISKISPGAFAPLVKLERLYLSK 139 LDL + NL L+ L + N + P A A L +L LY++ Sbjct: 51 RVNNLDLSGLNLPKPYPIPSSLANLPYLNFLYIGGINNLVGPIPPAIAKLTQLHYLYITH 110 Query: 140 NQLK-ELPEKMP--KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIEN-G 195 + +P+ + KTL L N ++ + L ++ + N + + ++ G Sbjct: 111 TNVSGAIPDFLSQIKTLVTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISGAIPDSYG 170 Query: 196 AFQGMKKLSYIRIADTNIT-TIPQGLPP-SLTELHLDGNKITKVDAASLKGLNNLAKLGL 253 +F + + + I+ +T IP +L + L N + + N K+ L Sbjct: 171 SFSKL--FTSMTISRNRLTGKIPPTFANLNLAFVDLSRNMLEGDASVLFGSDKNTQKIHL 228 Query: 254 SFNSISAVDNGSLANTPHLRELHLNNNKLVK-VPGGLADHKYIQVVYLHNNNISAIGSND 312 + NS++ D G + + +L L L NN++ +P GL K++ + + NN+ Sbjct: 229 AKNSLA-FDLGKVGLSKNLNGLDLRNNRIYGTLPQGLTQLKFLHSLNVSFNNLCGE---- 283 Query: 313 FCPPGYNTKKASYS 326 P G N ++ S Sbjct: 284 -IPQGGNLQRFDVS 296 Score = 54.3 bits (129), Expect = 7e-08, Method: Composition-based stats. Identities = 34/181 (18%), Positives = 61/181 (33%), Gaps = 8/181 (4%) Query: 156 LRVHENEITKVRK--SVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNI 213 L + + K S L + + +G I A + +L Y+ I TN+ Sbjct: 55 LDLSGLNLPKPYPIPSSLANLPYLNFLYIGGINNLVGPIPP-AIAKLTQLHYLYITHTNV 113 Query: 214 TTIPQGLPP---SLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTP 270 + +L L N ++ S+ L NL + N IS S + Sbjct: 114 SGAIPDFLSQIKTLVTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISGAIPDSYGSFS 173 Query: 271 HL-RELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVS 329 L + ++ N+L + + V L N + ++ NT+K + S Sbjct: 174 KLFTSMTISRNRLTGKIPPTFANLNLAFVDLSRNMLEG-DASVLFGSDKNTQKIHLAKNS 232 Query: 330 L 330 L Sbjct: 233 L 233 >5YXM-A nrPDB Length = 203 Score = 64.0 bits (154), Expect = 9e-11, Method: Composition-based stats. Identities = 37/156 (23%), Positives = 64/156 (41%), Gaps = 18/156 (11%) Query: 99 DGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELP--EKMPKTLQEL 156 D LK L L N I KIS + + + L L L +N +K++ + + TL+EL Sbjct: 46 DATLSTLKACKHLALSTNNIEKIS--SLSGMENLRILSLGRNLIKKIENLDAVADTLEEL 103 Query: 157 RVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTI 216 + N+I + S L + V+ + N + + G E + KL + +A + Sbjct: 104 WISYNQIASL--SGIEKLVNLRVLYMSNNKITNWG-EIDKLAALDKLEDLLLAGNPLYND 160 Query: 217 PQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLG 252 + + N ++ +K L NL KL Sbjct: 161 YK-----------ENNATSEYRIEVVKRLPNLKKLD 185 Score = 57.8 bits (138), Expect = 6e-09, Method: Composition-based stats. Identities = 29/107 (27%), Positives = 50/107 (46%), Gaps = 4/107 (3%) Query: 227 LHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVP 286 L L N I K+ +SL G+ NL L L N I ++N L EL ++ N++ + Sbjct: 58 LALSTNNIEKI--SSLSGMENLRILSLGRNLIKKIENLDAVADT-LEELWISYNQIASLS 114 Query: 287 GGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSN 333 G+ ++V+Y+ NN I+ G D + +G L+++ Sbjct: 115 -GIEKLVNLRVLYMSNNKITNWGEIDKLAALDKLEDLLLAGNPLYND 160 Score = 55.5 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 35/115 (30%), Positives = 51/115 (44%), Gaps = 7/115 (6%) Query: 85 ALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISP-GAFAPLVKLERLYLSKNQLK 143 L L N I +I ++NL L L N I KI A A LE L++S NQ+ Sbjct: 56 KHLALSTNNIEKI--SSLSGMENLRILSLGRNLIKKIENLDAVAD--TLEELWISYNQIA 111 Query: 144 ELPE-KMPKTLQELRVHENEITKVRK-SVFNGLNQMIVVELGTNPLKSSGIENGA 196 L + L+ L + N+IT + L+++ + L NPL + EN A Sbjct: 112 SLSGIEKLVNLRVLYMSNNKITNWGEIDKLAALDKLEDLLLAGNPLYNDYKENNA 166 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 22/100 (22%), Positives = 43/100 (43%), Gaps = 10/100 (10%) Query: 239 AASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVV 298 A+L L L LS N+I + SL+ +LR L L N + K+ A ++ + Sbjct: 46 DATLSTLKACKHLALSTNNIEKIS--SLSGMENLRILSLGRNLIKKIENLDAVADTLEEL 103 Query: 299 YLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQYW 338 ++ N I+++ + K + + + +N + W Sbjct: 104 WISYNQIASLSGIE--------KLVNLRVLYMSNNKITNW 135 >2BNH-A nrPDB Length = 457 Score = 63.6 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 65/348 (18%), Positives = 114/348 (32%), Gaps = 55/348 (15%) Query: 38 PEEHFPEVPEIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPP---DTALLDLQNNKI 94 EEH ++ P C LR + D G+ V + L L LQN + Sbjct: 37 TEEHCKDIGSALRANPSLTELC---LRTNELGDAGVHLVLQGLQSPTCKIQKLSLQNCSL 93 Query: 95 TE----IKDGDFKNLKNLHTLILINNKISK-----ISPGAFAPLVKLERLYLSKNQLKEL 145 TE + ++L L L L +N + + G P LE+L L +L Sbjct: 94 TEAGCGVLPSTLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPQCHLEKLQLEYCRLTAA 153 Query: 146 PEKMPKT-------LQELRVHENEI-----TKVRKSVFNGLNQMIVVELGTNPLKSSGIE 193 + + L+EL V N+I + + + + Q+ + L L + + Sbjct: 154 SCEPLASVLRATRALKELTVSNNDIGEAGARVLGQGLADSACQLETLRLENCGLTPANCK 213 Query: 194 N--GAFQGMKKLSYIRIADTNI-----TTIPQGLPP---SLTELHLDGNKITKVDAASL- 242 + G L + + + + GL L L L IT L Sbjct: 214 DLCGIVASQASLRELDLGSNGLGDAGIAELCPGLLSPASRLKTLWLWECDITASGCRDLC 273 Query: 243 ---KGLNNLAKLGLSFNSISA-----VDNGSLANTPHLRELHLNNNKL-----VKVPGGL 289 + L +L L+ N + + L L L + + L V L Sbjct: 274 RVLQAKETLKELSLAGNKLGDEGARLLCESLLQPGCQLESLWVKSCSLTAACCQHVSLML 333 Query: 290 ADHKYIQVVYLHNNNISAIGSNDFC----PPGYNTKKASYSGVSLFSN 333 +K++ + L +N + G + C PG + + ++ Sbjct: 334 TQNKHLLELQLSSNKLGDSGIQELCQALSQPGTTLRVLCLGDCEVTNS 381 >4PEQ-B nrPDB Length = 456 Score = 62.4 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 56/354 (15%), Positives = 111/354 (31%), Gaps = 85/354 (24%) Query: 60 QCHLRVVQCSDLGLEKVPKDLPPD--TALLDLQNNKITE-----IKDGDFKNLKNLHTLI 112 C L V+C D+G L + L L+ N++ + + G + L Sbjct: 32 DCGLTEVRCKDIG-----SALQANASLTELSLRTNELGDGGVLLVLQGLQSPTCKIQKLS 86 Query: 113 LINNKIS----KISPGAFAPLVKLERLYLSKNQLKELPEKMPKT--------LQELRVHE 160 L N ++ + PG L L L+LS N L + ++ L++L++ Sbjct: 87 LQNCCLTEAGCGVLPGVLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLEY 146 Query: 161 NEITKVRKSVFNGL----NQMIVVELGTNPLKSSGIE---NGAFQGMKKLSYIRIADTNI 213 +T + + + + N + +G++ G + +L +++ + + Sbjct: 147 CSLTAASCEPLAAVLRATRDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLENCGL 206 Query: 214 TTIPQ-------GLPPSLTELHLDGNKI-----TKVDAASLKGLNNLAKLGLSFNSISAV 261 T SL +L L N++ ++ L + L L L ++ Sbjct: 207 TAANCKDLCGIVASQASLKDLDLGSNRLGDAGLAELCPGLLSPSSQLRTLWLWECDLTVS 266 Query: 262 DNGSLANTPH----LRELHLNNNKL----------------------------------V 283 L L+EL L N L Sbjct: 267 GCRELCRVLQAKEALKELSLAGNSLGDEGAQLLCESLLQPGCQLESLWVKSCGFTAACCQ 326 Query: 284 KVPGGLADHKYIQVVYLHNNNISAIGSNDFC----PPGYNTKKASYSGVSLFSN 333 L +K++ + L +N + G + C PG + L ++ Sbjct: 327 HFSSMLTQNKHLLELQLSSNPLGDAGVHVLCQALGQPGTVLRVLWVGDCELTNS 380 Score = 50.9 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 65/383 (16%), Positives = 123/383 (32%), Gaps = 89/383 (23%) Query: 21 QKGLFDFMLEDEASGIGPEEHFPEVP----EIEPMGPVCPFRC----QCHLRVVQCSDLG 72 GL + +D S + E+ E+ G + + C ++ + + Sbjct: 32 DCGLTEVRCKDIGSALQANASLTELSLRTNELGDGGVLLVLQGLQSPTCKIQKLSLQNCC 91 Query: 73 LEK-----VPKDLP--PDTALLDLQNN-----KITEIKDGDFKNLKNLHTLILINNKIS- 119 L + +P L P L L +N + + +G L L L ++ Sbjct: 92 LTEAGCGVLPGVLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLEYCSLTA 151 Query: 120 -KISPGA--FAPLVKLERLYLSKNQLKE-----LPEKMPKT---LQELRVHENEITKVRK 168 P A L+ L +S N + E L + ++ L+ L++ +T Sbjct: 152 ASCEPLAAVLRATRDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLENCGLTAANC 211 Query: 169 SVFNG----LNQMIVVELGTNPLKSSGIE---NGAFQGMKKLSYIRIADTNIT-----TI 216 G + ++LG+N L +G+ G +L + + + ++T + Sbjct: 212 KDLCGIVASQASLKDLDLGSNRLGDAGLAELCPGLLSPSSQLRTLWLWECDLTVSGCREL 271 Query: 217 PQGLP--PSLTELHLDGNKITK-----VDAASLKGLNNLAKLGLSFNSISAVDNGSLANT 269 + L +L EL L GN + + + L+ L L + +A ++ Sbjct: 272 CRVLQAKEALKELSLAGNSLGDEGAQLLCESLLQPGCQLESLWVKSCGFTAACCQHFSSM 331 Query: 270 ----PHLRELHLNNNKL------------------------------VKVPGGLADHK-- 293 HL EL L++N L GGLA Sbjct: 332 LTQNKHLLELQLSSNPLGDAGVHVLCQALGQPGTVLRVLWVGDCELTNSSCGGLASLLLA 391 Query: 294 --YIQVVYLHNNNISAIGSNDFC 314 ++ + L NN + G Sbjct: 392 SPSLRELDLSNNGLGDPGVLQLL 414 Score = 45.1 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 61/276 (22%), Positives = 91/276 (32%), Gaps = 44/276 (15%) Query: 61 CHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKI-----TEIKDGDFKNLKNLHTLILIN 115 C L C L V + D L + NN I + G ++ L TL L N Sbjct: 147 CSLTAASCE--PLAAVLRA-TRDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLEN 203 Query: 116 NKIS--KISP--GAFAPLVKLERLYLSKNQL-----KELPEKMPK---TLQELRVHENEI 163 ++ G A L+ L L N+L EL + L+ L + E ++ Sbjct: 204 CGLTAANCKDLCGIVASQASLKDLDLGSNRLGDAGLAELCPGLLSPSSQLRTLWLWECDL 263 Query: 164 T----KVRKSVFNGLNQMIVVELGTNPLKSSG---IENGAFQGMKKLSYIRIADTNITTI 216 T + V + + L N L G + Q +L + + T Sbjct: 264 TVSGCRELCRVLQAKEALKELSLAGNSLGDEGAQLLCESLLQPGCQLESLWVKSCGFTAA 323 Query: 217 PQGLPPS-------LTELHLDGNKITKVDAASL-----KGLNNLAKLGLSFNSISAVDNG 264 S L EL L N + L + L L + ++ G Sbjct: 324 CCQHFSSMLTQNKHLLELQLSSNPLGDAGVHVLCQALGQPGTVLRVLWVGDCELTNSSCG 383 Query: 265 SLANT----PHLRELHLNNNKLVKVPGGLADHKYIQ 296 LA+ P LREL L+NN L PG L ++ Sbjct: 384 GLASLLLASPSLRELDLSNNGLGD-PGVLQLLGSLE 418 Score = 33.5 bits (75), Expect = 0.14, Method: Composition-based stats. Identities = 35/158 (22%), Positives = 60/158 (37%), Gaps = 24/158 (15%) Query: 206 IRIADTNITTIPQ-------GLPPSLTELHLDGNKITKVD-AASLKGL----NNLAKLGL 253 +R+ D +T + SLTEL L N++ L+GL + KL L Sbjct: 28 VRLDDCGLTEVRCKDIGSALQANASLTELSLRTNELGDGGVLLVLQGLQSPTCKIQKLSL 87 Query: 254 SFNSISA----VDNGSLANTPHLRELHLNNNKLVK------VPGGLADHKYIQVVYLHNN 303 ++ V G L + P LRELHL++N L G L ++ + L Sbjct: 88 QNCCLTEAGCGVLPGVLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLEYC 147 Query: 304 NISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQ 341 +++A T+ + + +N + +Q Sbjct: 148 SLTAASCEPLAAVLRATR--DLKELVVSNNDIGEAGVQ 183 >4PBW-B nrPDB Length = 283 Score = 61.3 bits (147), Expect = 6e-10, Method: Composition-based stats. Identities = 27/138 (19%), Positives = 51/138 (36%), Gaps = 26/138 (18%) Query: 55 CPFRCQCHLRVVQC------------------SDLGLEKVP-KDLPPDTALLDLQN-NKI 94 CP C C + C S G + D+ + + ++N + Sbjct: 4 CPANCLCSKTDINCKKPDDGNLFPLLEGQDSGSSNGQTSIQITDISRNITSIHIENWKNL 63 Query: 95 TEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQ 154 + D + L L + N+ + I P AFA L + LS N+L L ++ +TL+ Sbjct: 64 QTLNAVDMELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQTLR 123 Query: 155 ELRVHENEITKVRKSVFN 172 + ++ ++ F Sbjct: 124 LFDL------RLERNPFQ 135 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 18/102 (17%), Positives = 43/102 (42%), Gaps = 2/102 (1%) Query: 207 RIADTNITTI-PQGLPPSLTELHLDG-NKITKVDAASLKGLNNLAKLGLSFNSISAVDNG 264 + T+I + ++T +H++ + ++A ++ L +L + + + + Sbjct: 34 SGSSNGQTSIQITDISRNITSIHIENWKNLQTLNAVDMELYTGLQRLTIRNSGLRNIQPR 93 Query: 265 SLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNIS 306 + A PHLR + L+ N+L + L + + L N Sbjct: 94 AFAKNPHLRYIDLSGNRLTTLSWQLFQTLRLFDLRLERNPFQ 135 Score = 33.9 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 22/119 (18%), Positives = 40/119 (33%), Gaps = 16/119 (13%) Query: 146 PEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELG-TNPLKSSGIENGAFQGMKKLS 204 ++Q + N IT + + L + V++ L+ I N G++ + Sbjct: 36 SSNGQTSIQITDISRN-ITSIHIENWKNLQTLNAVDMELYTGLQRLTIRNS---GLRNIQ 91 Query: 205 YIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDN 263 A P L + L GN++T + + L L L L N + Sbjct: 92 PRAFAKN----------PHLRYIDLSGNRLTTLSWQLFQTL-RLFDLRLERNPFQCSCD 139 Score = 33.5 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 20/117 (17%), Positives = 40/117 (34%), Gaps = 22/117 (18%) Query: 221 PPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNN 280 S+ + N IT + + K L L + + L+ L + N+ Sbjct: 40 QTSIQITDISRN-ITSIHIENWKNLQTLNAVDMEL-------------YTGLQRLTIRNS 85 Query: 281 KLVKV-PGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSNPVQ 336 L + P A + +++ + L N ++ + F + + L NP Q Sbjct: 86 GLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLF-------QTLRLFDLRLERNPFQ 135 >4PBV-A nrPDB Length = 268 Score = 60.5 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 24/123 (19%), Positives = 47/123 (38%), Gaps = 11/123 (8%) Query: 55 CPFRCQCHLRVVQC----SDLGLEKVPKDLPPDTALLDLQN-NKITEIKDGDFKNLKNLH 109 CP C C + C + + + ++N + + D + L Sbjct: 4 CPANCLCSKTDINCKKPDDGNLFPLLEGQDSRNITSIHIENWKNLQTLNAVDMELYTGLQ 63 Query: 110 TLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKS 169 L + N+ + I P AFA L + LS N+L L ++ +TL+ + ++ ++ Sbjct: 64 RLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQTLRLFDL------RLERN 117 Query: 170 VFN 172 F Sbjct: 118 PFQ 120 Score = 46.2 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 38/85 (44%), Gaps = 1/85 (1%) Query: 223 SLTELHLDG-NKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNK 281 ++T +H++ + ++A ++ L +L + + + + + A PHLR + L+ N+ Sbjct: 36 NITSIHIENWKNLQTLNAVDMELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNR 95 Query: 282 LVKVPGGLADHKYIQVVYLHNNNIS 306 L + L + + L N Sbjct: 96 LTTLSWQLFQTLRLFDLRLERNPFQ 120 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 16/98 (16%), Positives = 31/98 (31%), Gaps = 8/98 (8%) Query: 186 PLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGL 245 S I + + K L + D + T L L + + + + + Sbjct: 31 GQDSRNITSIHIENWKNLQTLNAVDMELYT-------GLQRLTIRNSGLRNIQPRAFAKN 83 Query: 246 NNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLV 283 +L + LS N ++ + L +L L N Sbjct: 84 PHLRYIDLSGNRLTTLSWQLFQTLR-LFDLRLERNPFQ 120 Score = 32.8 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 20/103 (19%), Positives = 35/103 (33%), Gaps = 15/103 (14%) Query: 162 EITKVRKSVFNGLNQMIVVELG-TNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGL 220 IT + + L + V++ L+ I N G++ + A Sbjct: 36 NITSIHIENWKNLQTLNAVDMELYTGLQRLTIRNS---GLRNIQPRAFAKN--------- 83 Query: 221 PPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDN 263 P L + L GN++T + + L L L L N + Sbjct: 84 -PHLRYIDLSGNRLTTLSWQLFQTL-RLFDLRLERNPFQCSCD 124 Score = 31.6 bits (70), Expect = 0.48, Method: Composition-based stats. Identities = 13/81 (16%), Positives = 32/81 (39%), Gaps = 8/81 (9%) Query: 257 SISAVDNGSLANTPHLRELHLNNNKLVKV-PGGLADHKYIQVVYLHNNNISAIGSNDFCP 315 ++ ++ + L+ L + N+ L + P A + +++ + L N ++ + F Sbjct: 47 NLQTLNAVDMELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLF-- 104 Query: 316 PGYNTKKASYSGVSLFSNPVQ 336 + + L NP Q Sbjct: 105 -----QTLRLFDLRLERNPFQ 120 >2IFG-A nrPDB Length = 347 Score = 56.6 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 31/119 (26%), Positives = 54/119 (45%), Gaps = 10/119 (8%) Query: 55 CPFRCQCHLRV-VQCSDLG----LEKVPKDLPPDTALLDLQNN-KITEIKDGDFKNLKNL 108 CP C H ++C+ G L +P + L ++N + ++ D + L L Sbjct: 1 CPDACCPHGSSGLRCTRDGALDSLHHLPG--AENLTELYIENQQHLQHLELRDLRGLGEL 58 Query: 109 HTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKMPK--TLQELRVHENEITK 165 L ++ + + ++P AF +L RL LS N L+ L K + +LQEL + N + Sbjct: 59 RNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHC 117 Score = 49.7 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 20/85 (23%), Positives = 39/85 (45%), Gaps = 1/85 (1%) Query: 222 PSLTELHLDGNK-ITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNN 280 +LTEL+++ + + ++ L+GL L L + + + V + TP L L+L+ N Sbjct: 31 ENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFN 90 Query: 281 KLVKVPGGLADHKYIQVVYLHNNNI 305 L + +Q + L N + Sbjct: 91 ALESLSWKTVQGLSLQELVLSGNPL 115 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 18/93 (19%), Positives = 39/93 (41%), Gaps = 5/93 (5%) Query: 171 FNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQ---GLPPSLTEL 227 G + + + N +E +G+ +L + I + + + P L+ L Sbjct: 27 LPGAENLTELYIE-NQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL 85 Query: 228 HLDGNKITKVDAASLKGLNNLAKLGLSFNSISA 260 +L N + + +++GL+ L +L LS N + Sbjct: 86 NLSFNALESLSWKTVQGLS-LQELVLSGNPLHC 117 Score = 29.7 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 16/92 (17%), Positives = 35/92 (38%), Gaps = 7/92 (7%) Query: 126 FAPLVKLERLYLSKN-QLKEL---PEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVE 181 L LY+ L+ L + L+ L + ++ + V F+ ++ + Sbjct: 27 LPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLN 86 Query: 182 LGTNPLKSSGIENGAFQGMKKLSYIRIADTNI 213 L N L+S + QG+ L + ++ + Sbjct: 87 LSFNALESLSWKT--VQGLS-LQELVLSGNPL 115 >2Q4G-W nrPDB Length = 461 Score = 52.8 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 53/329 (16%), Positives = 108/329 (32%), Gaps = 77/329 (23%) Query: 60 QCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDG-DFKNLK----NLHTLILI 114 C L +C D+ + P A L+L++N++ ++ + L+ + L L Sbjct: 37 DCGLTEARCKDI---SSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQ 93 Query: 115 NNKISKISPGAFAP----LVKLERLYLSKNQLKE-----LPEKMPK---TLQELRVHENE 162 N ++ G + L L+ L+LS N L + L E + L++L++ Sbjct: 94 NCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCS 153 Query: 163 ITKVRKSVFNGL----NQMIVVELGTNPLKSSGIEN---GAFQGMKKLSYIRIADTNITT 215 ++ + + + N + +G+ G +L +++ +T+ Sbjct: 154 LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTS 213 Query: 216 IPQ-------GLPPSLTELHLDGNKITKVDAA---------------------------- 240 SL EL L NK+ V A Sbjct: 214 DNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273 Query: 241 -----SLKGLNNLAKLGLSFNSISA-----VDNGSLANTPHLRELHLNNNKLV-----KV 285 L+ +L +L L+ N + + L L L + + Sbjct: 274 GDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHF 333 Query: 286 PGGLADHKYIQVVYLHNNNISAIGSNDFC 314 LA ++++ + + NN + G + C Sbjct: 334 SSVLAQNRFLLELQISNNRLEDAGVRELC 362 Score = 43.5 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 67/373 (17%), Positives = 111/373 (29%), Gaps = 105/373 (28%) Query: 47 EIEPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDL---PPDTALLDLQNNKITE----IKD 99 +I V P + +LR + D+G+ V + L L LQN +T + Sbjct: 47 DISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLS 106 Query: 100 GDFKNLKNLHTLILINN-----KISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTL- 153 + L L L L +N + + G P +LE+L L L + ++ Sbjct: 107 STLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVL 166 Query: 154 ------QELRVHENEIT--------------------------KVRKSVFNGL------- 174 +EL V N+I V L Sbjct: 167 RAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK 226 Query: 175 NQMIVVELGTNPLKSSGIE---NGAFQGMKKLSYIRIADTNITTIPQG-------LPPSL 224 + + LG+N L G+ G +L + I + IT G SL Sbjct: 227 ASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESL 286 Query: 225 TELHLDGNKITK-----VDAASLKGLNNLAKLGLSFNSISAVDNGSLANT----PHLREL 275 EL L GN++ + L+ L L + S +A ++ L EL Sbjct: 287 KELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346 Query: 276 HLNNNKLVK----------------------------------VPGGLADHKYIQVVYLH 301 ++NN+L + L + ++ + L Sbjct: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLS 406 Query: 302 NNNISAIGSNDFC 314 NN + G Sbjct: 407 NNCLGDAGILQLV 419 Score = 32.4 bits (72), Expect = 0.33, Method: Composition-based stats. Identities = 38/164 (23%), Positives = 72/164 (43%), Gaps = 28/164 (17%) Query: 196 AFQGMKKLSYIRIADTNITT-----IPQGL--PPSLTELHLDGNKITKVDAA-SLKGL-- 245 +++ +R+ D +T I L P+L EL+L N++ V L+GL Sbjct: 23 LLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQT 82 Query: 246 --NNLAKLGLSFNSISA----VDNGSLANTPHLRELHLNNN-----KLVKVPGGLADHK- 293 + KL L ++ V + +L P L+ELHL++N L + GL D + Sbjct: 83 PSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQC 142 Query: 294 YIQVVYLHNNNISAIGSNDFCPPGYNTKKA--SYSGVSLFSNPV 335 ++ + L ++SA C P + +A + +++ +N + Sbjct: 143 RLEKLQLEYCSLSAAS----CEPLASVLRAKPDFKELTVSNNDI 182 >6ICZ-o nrPDB Length = 255 Score = 52.4 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 35/120 (29%), Positives = 54/120 (45%), Gaps = 9/120 (7%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKEL- 145 +D +N+I ++ F L+ L TL++ NN+I +I G L L L L+ N L EL Sbjct: 47 IDFSDNEIRKL--DGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELG 104 Query: 146 ---PEKMPKTLQELRVHENEITK---VRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQG 199 P K+L L + N +T R V + Q+ V++ LK F+G Sbjct: 105 DLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQEAEKMFKG 164 Score = 49.7 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 40/108 (37%), Gaps = 6/108 (5%) Query: 204 SYIRIADTNITTIPQ--GLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAV 261 + + I I + N+I K+D L L L ++ N I + Sbjct: 22 RELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLD--GFPLLRRLKTLLVNNNRICRI 79 Query: 262 DNGSLANTPHLRELHLNNNKLVKVP--GGLADHKYIQVVYLHNNNISA 307 G P L EL L NN LV++ LA K + + + N ++ Sbjct: 80 GEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTN 127 Score = 49.3 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 30/138 (21%), Positives = 59/138 (42%), Gaps = 12/138 (8%) Query: 154 QELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNI 213 +EL + +I + +++ L+Q ++ N ++ F +++L + + + I Sbjct: 22 RELDLRGYKIPVI-ENLGATLDQFDAIDFSDNEIRKL----DGFPLLRRLKTLLVNNNRI 76 Query: 214 TTIPQGL---PPSLTELHLDGNKITKV-DAASLKGLNNLAKLGLSFNSIS---AVDNGSL 266 I +GL P LTEL L N + ++ D L L +L L + N ++ + Sbjct: 77 CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVI 136 Query: 267 ANTPHLRELHLNNNKLVK 284 P +R L KL + Sbjct: 137 YKVPQVRVLDFQKVKLKE 154 Score = 38.9 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 18/64 (28%), Positives = 28/64 (43%), Gaps = 1/64 (1%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISP-GAFAPLVKLERLYLSKN 140 L + NN+I I +G + L L LIL NN + ++ A L L L + +N Sbjct: 64 RRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRN 123 Query: 141 QLKE 144 + Sbjct: 124 PVTN 127 >2CA6-A nrPDB Length = 386 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 53/226 (23%), Positives = 82/226 (36%), Gaps = 45/226 (19%) Query: 104 NLKNLHTLILINNKI--SKISP--GAFAPLVKLERLYLSKNQLK-ELPEKMPKTLQELRV 158 LHT+ L +N + P + LE LYL N L + K+ + LQEL V Sbjct: 92 KCPKLHTVRLSDNAFGPTAQEPLIDFLSKHTPLEHLYLHNNGLGPQAGAKIARALQELAV 151 Query: 159 H-------------------ENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQG 199 + EN K F + V++ N ++ GIE+ +G Sbjct: 152 NKKAKNAPPLRSIICGRNRLENGSMKEWAKTFQSHRLLHTVKMVQNGIRPEGIEHLLLEG 211 Query: 200 MK---KLSYIRIADTNITTIPQGLP-------PSLTELHLDGNKITKVDAA----SLKGL 245 + +L + + D T + P+L EL L+ ++ AA + L Sbjct: 212 LAYCQELKVLDLQDNTFTHLGSSALAIALKSWPNLRELGLNDCLLSARGAAAVVDAFSKL 271 Query: 246 NN--LAKLGLSFNSISAVDNGSL-----ANTPHLRELHLNNNKLVK 284 N L L L +N I +L P L L LN N+ + Sbjct: 272 ENIGLQTLRLQYNEIELDAVRTLKTVIDEKMPDLLFLELNGNRFSE 317 Score = 27.8 bits (60), Expect = 8.7, Method: Composition-based stats. Identities = 28/188 (14%), Positives = 59/188 (31%), Gaps = 36/188 (19%) Query: 150 PKTLQELRVHENEITKVRKSVFNGLNQ----MIVVELGTNPLKSSGIENGAFQGMKKLSY 205 L +R+ +N + + + L N L A + +++L+ Sbjct: 93 CPKLHTVRLSDNAFGPTAQEPLIDFLSKHTPLEHLYLHNNGLGPQAGAKIA-RALQELAV 151 Query: 206 IRIADTNITTIPQGLPPSLTELHLDGNKIT----KVDAASLKGLNNLAKLGLSFNSISAV 261 + A P L + N++ K A + + L + + N I Sbjct: 152 NKKAKNA---------PPLRSIICGRNRLENGSMKEWAKTFQSHRLLHTVKMVQNGIRPE 202 Query: 262 DNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTK 321 + L L GLA + ++V+ L +N + +GS+ + Sbjct: 203 G---------IEHLLLE---------GLAYCQELKVLDLQDNTFTHLGSSALAIALKSWP 244 Query: 322 KASYSGVS 329 G++ Sbjct: 245 NLRELGLN 252 >3JB9-j nrPDB Length = 239 Score = 49.3 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 6/79 (7%) Query: 87 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKEL- 145 +D +N I + G+F +K L TL+ NN+I+ I+P L L+ L L++N L+E+ Sbjct: 46 IDFTDNDIRYL--GNFPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIA 103 Query: 146 ---PEKMPKTLQELRVHEN 161 P L L +N Sbjct: 104 DLDPLASCPQLTNLSCIDN 122 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 18/62 (29%), Positives = 28/62 (45%), Gaps = 1/62 (1%) Query: 224 LTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDN-GSLANTPHLRELHLNNNKL 282 L L N+IT + K L NL L L+ N + + + LA+ P L L +N + Sbjct: 65 LQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASCPQLTNLSCIDNPV 124 Query: 283 VK 284 + Sbjct: 125 AQ 126 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 23/143 (16%), Positives = 48/143 (33%), Gaps = 26/143 (18%) Query: 72 GLEKVPKDLPP-DTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLV 130 L +VP + P LDL+ +I I++ + + +N I + G F + Sbjct: 7 FLSQVPSFISPLKETELDLRWYQIPIIENLGVLRDVH-DAIDFTDNDIRYL--GNFPRMK 63 Query: 131 KLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSS 190 +L+ L N++ + + K L + + L N L+ Sbjct: 64 RLQTLLCGNNRITAIAPDIGKVL---------------------PNLKTLSLAQNHLQEI 102 Query: 191 GIENGAFQGMKKLSYIRIADTNI 213 + +L+ + D + Sbjct: 103 A-DLDPLASCPQLTNLSCIDNPV 124 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 16/83 (19%), Positives = 31/83 (37%), Gaps = 4/83 (4%) Query: 227 LHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVP 286 + N I + + + L L N I+A+ P+L+ L L N L ++ Sbjct: 46 IDFTDNDIRYL--GNFPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIA 103 Query: 287 --GGLADHKYIQVVYLHNNNISA 307 LA + + +N ++ Sbjct: 104 DLDPLASCPQLTNLSCIDNPVAQ 126 Score = 35.1 bits (79), Expect = 0.047, Method: Composition-based stats. Identities = 19/63 (30%), Positives = 26/63 (41%), Gaps = 1/63 (1%) Query: 83 DTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISP-GAFAPLVKLERLYLSKNQ 141 L NN+IT I K L NL TL L N + +I+ A +L L N Sbjct: 64 RLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASCPQLTNLSCIDNP 123 Query: 142 LKE 144 + + Sbjct: 124 VAQ 126 Score = 33.9 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 15/62 (24%), Positives = 28/62 (45%), Gaps = 4/62 (6%) Query: 63 LRVVQCSDLGLEKVPKDLP---PDTALLDLQNNKITEIKDGD-FKNLKNLHTLILINNKI 118 L+ + C + + + D+ P+ L L N + EI D D + L L I+N + Sbjct: 65 LQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASCPQLTNLSCIDNPV 124 Query: 119 SK 120 ++ Sbjct: 125 AQ 126 Score = 33.1 bits (74), Expect = 0.18, Method: Composition-based stats. Identities = 19/126 (15%), Positives = 38/126 (30%), Gaps = 21/126 (16%) Query: 154 QELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNI 213 + +N+I + F + ++ + G N + + I + + L + +A ++ Sbjct: 44 DAIDFTDNDIRYL--GNFPRMKRLQTLLCGNNRI--TAIAPDIGKVLPNLKTLSLAQNHL 99 Query: 214 TTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLR 273 I LD AS L NL+ + + P L Sbjct: 100 QEIA----------DLD-------PLASCPQLTNLSCIDNPVAQKQYYRLYLIWRIPSLH 142 Query: 274 ELHLNN 279 L Sbjct: 143 ILDFER 148 >1DCE-A nrPDB Length = 567 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 27/107 (25%), Positives = 44/107 (41%), Gaps = 4/107 (3%) Query: 224 LTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLV 283 + LHL +T + L+ L + L LS N + A+ +LA L L ++N L Sbjct: 443 VRVLHLAHKDLTVL--CHLEQLLLVTHLDLSHNRLRALPP-ALAALRCLEVLQASDNALE 499 Query: 284 KVPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSL 330 V G+A+ +Q + L NN + + + G SL Sbjct: 500 NV-DGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSL 545 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 19/84 (22%), Positives = 34/84 (40%), Gaps = 7/84 (8%) Query: 84 TALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLK 143 LDL +N++ + L+ L L +N + + A L +L+ L L N+L+ Sbjct: 465 VTHLDLSHNRLRALPPA-LAALRCLEVLQASDNALENV--DGVANLPRLQELLLCNNRLQ 521 Query: 144 EL----PEKMPKTLQELRVHENEI 163 + P L L + N + Sbjct: 522 QSAAIQPLVSCPRLVLLNLQGNSL 545 Score = 45.1 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 24/134 (17%), Positives = 53/134 (39%), Gaps = 8/134 (5%) Query: 105 LKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPEKM--PKTLQELRVHENE 162 ++ L L + ++ + L+ + L LS N+L+ LP + + L+ L+ +N Sbjct: 440 YADVRVLHLAHKDLTVLC--HLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNA 497 Query: 163 ITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPP 222 + V L ++ + L N L+ S +L + + ++ +G+ Sbjct: 498 LENV--DGVANLPRLQELLLCNNRLQQSA-AIQPLVSCPRLVLLNLQGNSL-CQEEGIQE 553 Query: 223 SLTELHLDGNKITK 236 L E+ + I Sbjct: 554 RLAEMLPSVSSILT 567 Score = 40.9 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 19/112 (16%), Positives = 42/112 (37%), Gaps = 10/112 (8%) Query: 247 NLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNIS 306 ++ L L+ ++ + + L + L L++N+L +P LA + ++V+ +N + Sbjct: 442 DVRVLHLAHKDLTVLCH--LEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALE 499 Query: 307 AIGSNDFCPPGYNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRAAVQLGN 358 + P + L +N +Q C + GN Sbjct: 500 NVDGVANLP--------RLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGN 543 >6J5T-G nrPDB Length = 852 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 34/176 (19%), Positives = 67/176 (38%), Gaps = 23/176 (13%) Query: 116 NKISKISPGAFAPLVKLERLYLSKN----QLKELPEKMPKTLQEL---RVHENEITKVRK 168 NK++ F L L +SK+ L E+ +++ +LQ L + Sbjct: 545 NKLNSDLAKKFTDCKYLRVLDISKSIFDAPLSEILDEI-ASLQHLACLSLSNTHPLIQFP 603 Query: 169 SVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADT-NITTIPQGLPPSLTEL 227 L+ + +++ ++ KKL + + + ++ P+G+ SL +L Sbjct: 604 RSMEDLHNLQILDASY-CQNLKQLQPCIVLF-KKLLVLDMTNCGSLECFPKGIG-SLVKL 660 Query: 228 HL--------DGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLREL 275 + N + +K L NL KLGLS ++ L + +L +L Sbjct: 661 EVLLGFKPARSNNGCK---LSEVKNLTNLRKLGLSLTRGDQIEEEELDSLINLSKL 713 Score = 35.5 bits (80), Expect = 0.039, Method: Composition-based stats. Identities = 30/150 (20%), Positives = 54/150 (36%), Gaps = 24/150 (16%) Query: 100 GDFKNLKNLHTLILINNKISKISPGAFAPLVKLERL-YLSKNQLKELPEKMPKTLQELRV 158 + KNL NL L L + +I L+ L +L +S N + + Sbjct: 678 SEVKNLTNLRKLGLSLTRGDQIEEEELDSLINLSKLMSISINCYDSYGDDL--------- 728 Query: 159 HENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQ 218 ITK+ +Q+ + L P KSS + + L Y+ I N+ + + Sbjct: 729 ----ITKI--DALTPPHQLHELSLQFYPGKSSPSWLSPHK-LPMLRYMSICSGNLVKMQE 781 Query: 219 GLPPSLTELHLDGNKITKVDAASLKGLNNL 248 + N +++ L L++L Sbjct: 782 PFWGN-------ENTHWRIEGLMLSSLSDL 804 Score = 29.7 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 26/77 (33%), Gaps = 1/77 (1%) Query: 223 SLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNN-NK 281 L L L S++ L+NL L S+ + L L + N Sbjct: 587 HLACLSLSNTHPLIQFPRSMEDLHNLQILDASYCQNLKQLQPCIVLFKKLLVLDMTNCGS 646 Query: 282 LVKVPGGLADHKYIQVV 298 L P G+ ++V+ Sbjct: 647 LECFPKGIGSLVKLEVL 663 >3TSR-E nrPDB Length = 457 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 56/277 (20%), Positives = 93/277 (33%), Gaps = 54/277 (19%) Query: 61 CHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITE-----IKDGDFKNLKNLHTLILIN 115 C+L C L V + + D L L NN + E + G + L +L L N Sbjct: 148 CNLTATSCE--PLASVLR-VKADFKELVLSNNDLHEPGVRILCQGLKDSACQLESLKLEN 204 Query: 116 NKIS--KISP--GAFAPLVKLERLYLSKNQLKEL------PEKMPKT--LQELRVHENEI 163 I+ A L+ L LS N+L P + + L+ L + E +I Sbjct: 205 CGITAANCKDLCDVVASKASLQELDLSSNKLGNAGIAALCPGLLLPSCKLRTLWLWECDI 264 Query: 164 T----KVRKSVFNGLNQMIVVELGTNPLKSSG---IENGAFQGMKKLSYIRIADTNITTI 216 T K V + + L +N LK G + + +L + I ++T Sbjct: 265 TAEGCKDLCRVLRAKQSLKELSLASNELKDEGARLLCESLLEPGCQLESLWIKTCSLTAA 324 Query: 217 PQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSI-----SAVDNGSLANTPH 271 S+ L +L +L +S N + + Sbjct: 325 SCPYFCSV-----------------LTKSRSLLELQMSSNPLGDEGVQELCKALSQPDTV 367 Query: 272 LRELHL-----NNNKLVKVPGGLADHKYIQVVYLHNN 303 LREL L N+ + L ++ ++ + L NN Sbjct: 368 LRELWLGDCDVTNSGCSSLANVLLANRSLRELDLSNN 404 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 38/194 (19%), Positives = 65/194 (33%), Gaps = 29/194 (14%) Query: 151 KTLQELRVHENEI-TKVRKSVFNGLNQ----MIVVELGTNPLKSSG--IENGAFQGMKKL 203 L EL + NE+ V GL + + L L +G I G + + L Sbjct: 52 PALTELSLRTNELGDGGVGLVLQGLQNPTCKIQKLSLQNCGLTEAGCGILPGMLRSLSTL 111 Query: 204 SYIRIADT-----NITTIPQGLPP---SLTELHLDGNKITKVDAASLKGL----NNLAKL 251 + + D + + +GL L +L L+ +T L + + +L Sbjct: 112 RELHLNDNPMGDAGLKLLCEGLQDPQCRLEKLQLEYCNLTATSCEPLASVLRVKADFKEL 171 Query: 252 GLSFNSISA-----VDNGSLANTPHLRELHLNN-----NKLVKVPGGLADHKYIQVVYLH 301 LS N + + G + L L L N + +A +Q + L Sbjct: 172 VLSNNDLHEPGVRILCQGLKDSACQLESLKLENCGITAANCKDLCDVVASKASLQELDLS 231 Query: 302 NNNISAIGSNDFCP 315 +N + G CP Sbjct: 232 SNKLGNAGIAALCP 245 >5LJ5-W nrPDB Length = 238 Score = 41.6 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 27/112 (24%), Positives = 50/112 (44%), Gaps = 12/112 (10%) Query: 78 KDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYL 137 K L T +LDL NN + I D ++HTL+L N I ++ + ++ L L Sbjct: 48 KHLTKPTHILDLTNNDLIMIP--DLSRRDDIHTLLLGRNNIVEVDGRLLP--MNVQNLTL 103 Query: 138 SKNQLKELPE-----KMPKTLQELRVHEN---EITKVRKSVFNGLNQMIVVE 181 S N ++ + + P+TL+ L + N + R+ V + + ++ Sbjct: 104 SNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHLANYREHVLRLVPHLETLD 155 Score = 37.4 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 22/112 (19%), Positives = 44/112 (39%), Gaps = 14/112 (12%) Query: 208 IADTNITTIPQGLPPSLTEL-------HLDGNKITKVDAASLKGLNNLAKLGLSFNSISA 260 + D + T + +P SL L L N + + L +++ L L N+I Sbjct: 31 LRDLQLETDSESMPSSLKHLTKPTHILDLTNNDLIMIP--DLSRRDDIHTLLLGRNNIVE 88 Query: 261 VDNGSLANTPHLRELHLNNNKLVKVPGGLADH---KYIQVVYLHNNNISAIG 309 VD L +++ L L+NN + + + ++ + L N + + Sbjct: 89 VDGRLLPM--NVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHLA 138 Score = 35.5 bits (80), Expect = 0.036, Method: Composition-based stats. Identities = 29/147 (19%), Positives = 48/147 (32%), Gaps = 31/147 (21%) Query: 141 QLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGM 200 QL+ E MP +L+ L I + + + + + Sbjct: 35 QLETDSESMPSSLKHLT-KPTHILDLTNNDLIMIPDLSRRD------------------- 74 Query: 201 KKLSYIRIADTNITTIPQGLPP-SLTELHLDGNKITKVDAASLKGLNN----LAKLGLSF 255 + + + NI + L P ++ L L N I + + L+ L L L L Sbjct: 75 -DIHTLLLGRNNIVEVDGRLLPMNVQNLTLSNNSIRRFE--DLQRLRRAPRTLKNLTLIG 131 Query: 256 NSISAVDNG---SLANTPHLRELHLNN 279 N + + N L PHL L N Sbjct: 132 NQVCHLANYREHVLRLVPHLETLDFQN 158 Score = 30.1 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 17/67 (25%), Positives = 25/67 (37%), Gaps = 9/67 (13%) Query: 80 LPPDTALLDLQNNKITEIKDGDFKNLKN----LHTLILINNKISKIS---PGAFAPLVKL 132 LP + L L NN I D + L+ L L LI N++ ++ + L Sbjct: 94 LPMNVQNLTLSNNSIRRF--EDLQRLRRAPRTLKNLTLIGNQVCHLANYREHVLRLVPHL 151 Query: 133 ERLYLSK 139 E L Sbjct: 152 ETLDFQN 158 >6MDV-A nrPDB Length = 802 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 42/259 (16%), Positives = 90/259 (34%), Gaps = 48/259 (18%) Query: 72 GLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVK 131 G+ VP T+ +LQ +++ I D+ + L TL+ + + I Sbjct: 303 GVAHVPSTYKNRTST-NLQRHEVDNISHTDYTVSRKLKTLMTEDKRYDVIDQ-------- 353 Query: 132 LERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSG 191 K++P+ + +V + + R + + L + +++ Sbjct: 354 -----------KDIPDPALREQIIQQVGQYKGDLERYN--------KTLVLTGDKIQNLK 394 Query: 192 IENGAFQGMKKLSYIRIAD-TNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAK 250 + + KL + + +N+ I L P + K + G+ L K Sbjct: 395 ----GLEKLSKLQKLELRQLSNVKEITPELLPE---------SMKKDAELVMVGMTGLEK 441 Query: 251 LGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVV--YLHNNNISAI 308 L LS + +D + + HL +++N L + D K + + + N+ + Sbjct: 442 LNLSGLNRQTLDGIDVNSITHLTSFDISHNSL-DLSEKSEDRKLLMTLMEQVSNHQKITV 500 Query: 309 GSNDF---CPPGYNTKKAS 324 + F P GY + Sbjct: 501 KNTAFENQKPKGYYPQTYD 519 >1KOH-A nrPDB Length = 277 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 19/99 (19%), Positives = 44/99 (44%), Gaps = 5/99 (5%) Query: 212 NITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGS--LANT 269 + + P + ++ + + + + + L L LS N + +D+ S + Sbjct: 136 GLRSDPDLVAQNIDVVLNRRSSMAATLRIIEENIPELLSLNLSNNRLYRLDDMSSIVQKA 195 Query: 270 PHLRELHLNNNKLVKVPGGLADHK--YIQVVYLHNNNIS 306 P+L+ L+L+ N+L L K ++ ++L N++S Sbjct: 196 PNLKILNLSGNELKS-ERELDKIKGLKLEELWLDGNSLS 233 Score = 37.8 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 32/91 (35%), Gaps = 12/91 (13%) Query: 198 QGMKKLSYIRIADTNITTIPQGL-----PPSLTELHLDGNKITKVDAASLKGLNNLAKLG 252 + + +L + +++ + + P+L L+L GN++ L +L Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELW 226 Query: 253 LSFNSISA-------VDNGSLANTPHLRELH 276 L NS+S + P L L Sbjct: 227 LDGNSLSDTFRDQSTYISAIRERFPKLLRLD 257 Score = 37.4 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 17/70 (24%), Positives = 29/70 (41%), Gaps = 7/70 (10%) Query: 127 APLVKLERLYLSKNQLKELPE-----KMPKTLQELRVHENEITKVRK-SVFNGLNQMIVV 180 + +L L LS N+L L + + L+ L + NE+ R+ GL + + Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLK-LEEL 225 Query: 181 ELGTNPLKSS 190 L N L + Sbjct: 226 WLDGNSLSDT 235 Score = 33.1 bits (74), Expect = 0.17, Method: Composition-based stats. Identities = 24/157 (15%), Positives = 59/157 (37%), Gaps = 8/157 (5%) Query: 83 DTALLDLQNNKITEIKDGDFKNLKNLHTLILINN-KISKISPGAFAPLVKLERLYLSKNQ 141 + +LD +N +I+ I + L+ L ++ I + + L L Sbjct: 81 NYKILDRENRRISIIINSSAPPHTILNELKPEQVEQLKLIMSKRYDGSQ--QALDLKG-- 136 Query: 142 LKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMK 201 L+ P+ + + + + + + + + + +++ + L N L + Q Sbjct: 137 LRSDPDLVAQNIDVVLNRRSSMAATLRIIEENIPELLSLNLSNNRLYRLDDMSSIVQKAP 196 Query: 202 KLSYIRIADTNIT---TIPQGLPPSLTELHLDGNKIT 235 L + ++ + + + L EL LDGN ++ Sbjct: 197 NLKILNLSGNELKSERELDKIKGLKLEELWLDGNSLS 233 Score = 31.2 bits (69), Expect = 0.73, Method: Composition-based stats. Identities = 15/68 (22%), Positives = 29/68 (42%), Gaps = 4/68 (5%) Query: 267 ANTPHLRELHLNNNKLVKV---PGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKKA 323 N P L L+L+NN+L ++ + ++++ L N + + D G ++ Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELD-KIKGLKLEEL 225 Query: 324 SYSGVSLF 331 G SL Sbjct: 226 WLDGNSLS 233 Score = 28.9 bits (63), Expect = 3.6, Method: Composition-based stats. Identities = 15/73 (20%), Positives = 27/73 (36%), Gaps = 13/73 (17%) Query: 82 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 141 P+ +L+L N++ ++ D L L L N +S F Sbjct: 196 PNLKILNLSGNELKSERELDKIKGLKLEELWLDGNSLS----DTFRD---------QSTY 242 Query: 142 LKELPEKMPKTLQ 154 + + E+ PK L+ Sbjct: 243 ISAIRERFPKLLR 255 >4WYK-A nrPDB Length = 461 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 21/88 (23%), Positives = 34/88 (38%), Gaps = 3/88 (3%) Query: 57 FRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGD--FKNLKNLHTLILI 114 L C L + +++P L+L NN++ + D + NL L L Sbjct: 147 QNIDVVLNRRSCMAATLRIIEENIPE-LLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLS 205 Query: 115 NNKISKISPGAFAPLVKLERLYLSKNQL 142 N++ +KLE L+L N L Sbjct: 206 GNELKSERELDKIKGLKLEELWLDGNSL 233 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 32/91 (35%), Gaps = 12/91 (13%) Query: 198 QGMKKLSYIRIADTNITTIPQGL-----PPSLTELHLDGNKITKVDAASLKGLNNLAKLG 252 + + +L + +++ + + P+L L+L GN++ L +L Sbjct: 168 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELW 227 Query: 253 LSFNSI-------SAVDNGSLANTPHLRELH 276 L NS+ S + P L L Sbjct: 228 LDGNSLCDTFRDQSTYISAIRERFPKLLRLD 258 Score = 37.4 bits (85), Expect = 0.011, Method: Composition-based stats. Identities = 25/135 (18%), Positives = 48/135 (35%), Gaps = 16/135 (11%) Query: 127 APLVKLERLYLSKNQLKELPE-----KMPKTLQELRVHENEITKVRK-SVFNGLNQMIVV 180 + +L L LS N+L L + + L+ L + NE+ R+ GL + + Sbjct: 168 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLK-LEEL 226 Query: 181 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDA- 239 L N L + + + + + ++ + +P + + T + Sbjct: 227 WLDGNSLCDTFRDQSTYISAIRERFPKLLRLDGHELPPPIAFDVE-------APTTLPPC 279 Query: 240 -ASLKGLNNLAKLGL 253 S G NL L L Sbjct: 280 KGSYFGTENLKSLVL 294 Score = 31.6 bits (70), Expect = 0.59, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 23/49 (46%), Gaps = 3/49 (6%) Query: 267 ANTPHLRELHLNNNKLVKV---PGGLADHKYIQVVYLHNNNISAIGSND 312 N P L L+L+NN+L ++ + ++++ L N + + D Sbjct: 168 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELD 216 >6FE8-D nrPDB Length = 519 Score = 37.4 bits (85), Expect = 0.011, Method: Composition-based stats. Identities = 32/166 (19%), Positives = 67/166 (40%), Gaps = 19/166 (11%) Query: 74 EKVPKDLPPDTALLDLQN-NKITEIKDGDFKNLKNLHTLILINN---KISKIS-PGAFAP 128 + + + + L N+I+ DF NL L+L ++ I P F Sbjct: 300 KTISYIVKRRINEIRLSRMNQISRTGLADFTRWDNLQKLVLSRVAYIDLNSIVFPKNFKS 359 Query: 129 LV-----KLERLYLSKNQLKEL--PEKMPKTL--QELRVHENEITKVRKSVFNGLNQMIV 179 L K++ + +N LKEL ++ K+L +E + +R + L++ + Sbjct: 360 LTMKRVSKIKWWNIEENILKELKVDKRTFKSLYIKEDDSKFTKFFNLRHTRIKELDKSEI 419 Query: 180 VELGTNPLKSSGIENGAFQGMKKLSYIRIAD--TNITTIPQGLPPS 223 ++ L+ I +F+ + + +++ NI +P+ L S Sbjct: 420 NQITY--LRCQAIVWLSFRTLNHIKLQNVSEVFNNI-IVPRALFDS 462 Score = 30.5 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 27/177 (15%), Positives = 55/177 (31%), Gaps = 35/177 (19%) Query: 159 HENEITKVRKS----VFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNIT 214 N++T + + + + + L I F G + D Sbjct: 252 THNQLTSISVIRTIRSMESMKSLRKITVRGEKLYELLIN---FHGFR--------DNPGK 300 Query: 215 TIPQGLPPSLTELHLDG-NKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH-- 271 TI + + E+ L N+I++ A +NL KL LS + +++ Sbjct: 301 TISYIVKRRINEIRLSRMNQISRTGLADFTRWDNLQKLVLSRVAYIDLNSIVFPKNFKSL 360 Query: 272 -----------------LRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSN 311 L+EL ++ + D K+ + L + I + + Sbjct: 361 TMKRVSKIKWWNIEENILKELKVDKRTFKSLYIKEDDSKFTKFFNLRHTRIKELDKS 417 >4NUY-A nrPDB Length = 899 Score = 37.0 bits (84), Expect = 0.011, Method: Composition-based stats. Identities = 25/133 (18%), Positives = 46/133 (34%), Gaps = 14/133 (10%) Query: 160 ENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIP-Q 218 N ++ L + N K + G+ +++ + + P + Sbjct: 384 FNGTLRLDNPAIQSLEGL-------NKFKKLAQLD--LIGLSRITKLDRSVLPANMKPGK 434 Query: 219 GLPPSLTELHLDGNKIT--KVDAASLK--GLNNLAKLGLSFNSISAVDNGSLANTPHLRE 274 ++ E + NK + SLK GL L +L LS + A L + Sbjct: 435 DTLETVLETYKKDNKEEPATIPPVSLKVSGLTGLKELDLSGFDRETLAGLDAATLTSLEK 494 Query: 275 LHLNNNKLVKVPG 287 + ++ NKL PG Sbjct: 495 VDISGNKLDLAPG 507 >4K17-A nrPDB Length = 669 Score = 33.9 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 36/228 (15%), Positives = 81/228 (35%), Gaps = 49/228 (21%) Query: 128 PLVKLERLYLSKNQL-----KELP---EKMPKTLQELRVHENEIT---------KVRKSV 170 P L + L+ N L L K+PK L+ L + + ++ + + Sbjct: 275 PNSGLHTINLAGNSLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQSLSANP 334 Query: 171 FNGLNQMIVVELGTNPLKSSGIEN--GAFQGMKKLSYIRIADTN------ITTIPQGLPP 222 + + ++L N L+ + + + ++ +++T + + +G Sbjct: 335 LTA-STLTHLDLSGNALRGDDLSHMYNFLAQPNTIVHLDLSNTECSLEMVCSALLRGCLQ 393 Query: 223 SLTELHLDGN-----KITKVDAA---SLKGLNNLAKLGLSFNSISAVDNGS----LANTP 270 L L+L + K +V + L ++ LS +S + LA Sbjct: 394 CLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQINLSGTKLSPEPLKALLLGLACNH 453 Query: 271 HLR--ELHLNNNKL---------VKVPGGLADHKYIQVVYLHNNNISA 307 L+ L L+N +L + G +A+ I + + +N + + Sbjct: 454 SLKGVSLDLSNCELGHCLRSGGAQVLEGCIAEIHNITSLDISDNGLES 501 >1OWP-A nrPDB Length = 484 Score = 32.0 bits (71), Expect = 0.38, Method: Composition-based stats. Identities = 14/58 (24%), Positives = 23/58 (39%) Query: 77 PKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLER 134 P + T L+DL ++T I L L L + + PG A + +L+ Sbjct: 162 PTPVATPTELVDLSPEQLTAIAPLLLSELPTLKQLGFDWDGGFPVEPGETAAIARLQE 219 >1USY-C nrPDB Length = 275 Score = 29.7 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 13/67 (19%), Positives = 26/67 (38%), Gaps = 10/67 (14%) Query: 73 LEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFA--PLV 130 L+++PKDL L N + + L ++ + L ++ KI + Sbjct: 139 LKEIPKDLHEKVLNLIDTKN------LAEIEFLSHMKKIDLS--RVEKIIEDSIYRRSPE 190 Query: 131 KLERLYL 137 L+ + L Sbjct: 191 HLKTMDL 197 >2P1O-B nrPDB Length = 594 Score = 29.3 bits (64), Expect = 2.4, Method: Composition-based stats. Identities = 32/243 (13%), Positives = 82/243 (33%), Gaps = 34/243 (13%) Query: 108 LHTLILINNKISKISPGAFAPLVKLERLYLSK------NQLKELPEKMPKTLQELRVHEN 161 L +++ ++ + I+ + L LS + L + + L+EL + E+ Sbjct: 112 LKRMVVTDDCLELIA----KSFKNFKVLVLSSCEGFSTDGLAAIAAT-CRNLKELDLRES 166 Query: 162 EITKVRKSVFNGLN----QMIVVELGTNPLKSSGIENGAFQGM----KKLSYIRIADT-N 212 ++ V + ++ + + +S + A + + L +++ Sbjct: 167 DVDDVSGHWLSHFPDTYTSLVSLNIS---CLASEVSFSALERLVTRCPNLKSLKLNRAVP 223 Query: 213 ITTIPQGLP--PSLTELHLDG------NKITKVDAASLKGLNNLAKLGLSFNSISAVDNG 264 + + L P L EL G + + +L G L L ++++ A Sbjct: 224 LEKLATLLQRAPQLEELGTGGYTAEVRPDVYSGLSVALSGCKELRCLSGFWDAVPAYLPA 283 Query: 265 SLANTPHLRELHLNNNKLVK--VPGGLADHKYIQVVYLHNNNISAIGSNDFCPPGYNTKK 322 + L L+L+ + + L +Q +++ + I G + ++ Sbjct: 284 VYSVCSRLTTLNLSYATVQSYDLVKLLCQCPKLQRLWVLD-YIEDAGLEVLASTCKDLRE 342 Query: 323 ASY 325 Sbjct: 343 LRV 345 >2A90-A nrPDB Length = 240 Score = 29.3 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 30/91 (32%), Gaps = 3/91 (3%) Query: 249 AKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVK---VPGGLADHKYIQVVYLHNNNI 305 L LS I + +N LR+ + + P L Q L +N+ Sbjct: 145 QTLDLSNTHIGLPYTINFSNLTQLRQPSGPMRSIRRTQQAPYPLVKLTPQQANQLKSNSA 204 Query: 306 SAIGSNDFCPPGYNTKKASYSGVSLFSNPVQ 336 S + P +TK ++ +P+ Sbjct: 205 SVSSQYNTLPKLGDTKSLHRVPMTRQQHPLP 235 >5MG8-B nrPDB Length = 294 Score = 29.3 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 33/121 (27%), Gaps = 16/121 (13%) Query: 184 TNPLKSSGIENGAFQGM-KKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASL 242 ++P G FQG ++ N+ L + EL N + Sbjct: 5 SHPQFEKGALEVLFQGPGSQIEKRANESNNLQREIADLSEQIVELESKRNDLHSALLEMG 64 Query: 243 KGLNN-LAKLGLSFNSISAVD--------------NGSLANTPHLRELHLNNNKLVKVPG 287 L + L K N IS + N P L +L + P Sbjct: 65 GNLTSLLTKKDSIANKISDQSEHLKVLEDVQRDKVSAFGKNMPQLLKLITRETRFQHPPK 124 Query: 288 G 288 G Sbjct: 125 G 125 >4GIP-D nrPDB Length = 409 Score = 28.1 bits (61), Expect = 6.8, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 36/88 (40%), Gaps = 3/88 (3%) Query: 153 LQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKK-LSYIRIADT 211 L LR ++ V + L ++ + PL S + + L ++ +DT Sbjct: 313 LDNLRFTITQLANVTYNSTIKLESSQILSID--PLDISQNLAAVNKSLSDALQHLAQSDT 370 Query: 212 NITTIPQGLPPSLTELHLDGNKITKVDA 239 ++ I + L++++ N+I ++ Sbjct: 371 YLSAIEDKIEEILSKIYHIENEIARIKK 398 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.131 0.336 Lambda K H 0.267 0.0401 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,463,197 Number of Sequences: 36641 Number of extensions: 483888 Number of successful extensions: 4319 Number of sequences better than 10.0: 78 Number of HSP's better than 10.0 without gapping: 103 Number of HSP's successfully gapped in prelim test: 43 Number of HSP's that attempted gapping in prelim test: 1320 Number of HSP's gapped (non-prelim): 537 length of query: 360 length of database: 10,336,785 effective HSP length: 98 effective length of query: 262 effective length of database: 6,745,967 effective search space: 1767443354 effective search space used: 1767443354 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 60 (27.8 bits)