BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P21549 (392 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5LUC-A nrPDB 804 0.0 3KGX-A nrPDB 640 0.0 2HUU-A nrPDB 371 e-103 2CH1-A nrPDB 366 e-101 1VJO-A nrPDB 336 1e-92 3ISL-A nrPDB 222 2e-58 3NNK-A nrPDB 218 5e-57 2YRI-A nrPDB 179 2e-45 3ZRR-A nrPDB 140 1e-33 2DR1-A nrPDB 128 5e-30 2Z9W-A nrPDB 114 8e-26 1M32-A nrPDB 96 2e-20 2BKW-A nrPDB 92 5e-19 1IUG-A nrPDB 89 3e-18 3KE3-A nrPDB 74 9e-14 3FFR-A nrPDB 51 9e-07 3LVM-A nrPDB 40 0.002 5WT2-A nrPDB 40 0.002 3TQX-A nrPDB 40 0.002 4W91-A nrPDB 37 0.015 2E7J-A nrPDB 36 0.024 4Q6R-A nrPDB 36 0.025 1QZ9-A nrPDB 36 0.026 6ENZ-A nrPDB 36 0.033 6MRE-A nrPDB 35 0.054 4MY5-A nrPDB 34 0.12 4U5I-A nrPDB 33 0.22 1FC4-A nrPDB 33 0.26 5WGB-A nrPDB 32 0.34 4EB7-A nrPDB 32 0.44 3HQT-A nrPDB 32 0.64 2JIS-A nrPDB 30 1.3 5HH9-A nrPDB 30 1.8 1T3I-A nrPDB 30 1.8 5O5C-A nrPDB 30 1.9 3NIZ-A nrPDB 29 3.3 2JPD-A nrPDB 28 5.6 2JNW-A nrPDB 28 5.7 3WY7-A nrPDB 28 8.2 >5LUC-A nrPDB Length = 403 Score = 804 bits (2076), Expect = 0.0, Method: Compositional matrix adjust. Identities = 391/392 (99%), Positives = 392/392 (100%) Query: 1 MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI 60 MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI Sbjct: 12 MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI 71 Query: 61 KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG 120 KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG Sbjct: 72 KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG 131 Query: 121 ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL 180 ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL Sbjct: 132 ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL 191 Query: 181 LVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF 240 LV+SVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF Sbjct: 192 LVNSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF 251 Query: 241 YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG 300 YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG Sbjct: 252 YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG 311 Query: 301 RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR 360 RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR Sbjct: 312 RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR 371 Query: 361 IGLLGCNATRENVDRVTEALRAALQHCPKKKL 392 IGLLGCNATRENVDRVTEALRAALQHCPKKKL Sbjct: 372 IGLLGCNATRENVDRVTEALRAALQHCPKKKL 403 >3KGX-A nrPDB Length = 393 Score = 640 bits (1651), Expect = 0.0, Method: Compositional matrix adjust. Identities = 301/392 (76%), Positives = 338/392 (86%) Query: 1 MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI 60 M S++LLV PP+AL KPLS+P +LLLGPGPSNL PR++AAG L+MIG M K+M QIM+EI Sbjct: 2 MGSYQLLVPPPEALSKPLSVPTRLLLGPGPSNLAPRVLAAGSLRMIGHMQKEMLQIMEEI 61 Query: 61 KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG 120 K+GIQYVFQTRNPLTLV+SGSGHCA+E AL N+LEPGDSFL G NGIWG RA +I +RIG Sbjct: 62 KQGIQYVFQTRNPLTLVVSGSGHCAMETALFNLLEPGDSFLTGTNGIWGMRAAEIADRIG 121 Query: 121 ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL 180 ARVH M K PG HYTLQEVEEGLAQHKPVLLFL HGESSTGV+QPLDGFGELCHRY+CLL Sbjct: 122 ARVHQMIKKPGEHYTLQEVEEGLAQHKPVLLFLVHGESSTGVVQPLDGFGELCHRYQCLL 181 Query: 181 LVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF 240 LVDSVASLGG P+YMD+QGIDI+YS SQK LNAPPG SLISF+DKAK K+YSRKTKP SF Sbjct: 182 LVDSVASLGGVPIYMDQQGIDIMYSSSQKVLNAPPGISLISFNDKAKYKVYSRKTKPVSF 241 Query: 241 YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG 300 Y DI +LA WGC+ + R+ HHT PV SLY LRESLALIAEQGLEN WR+HREA A+LH Sbjct: 242 YTDITYLAKLWGCEGETRVIHHTTPVTSLYCLRESLALIAEQGLENCWRRHREATAHLHK 301 Query: 301 RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR 360 LQ +GL+ FVKDP +RLPT+TTV VPAGY+WRDIVSYV+DHF IEI GGLGP+ +VLR Sbjct: 302 HLQEMGLKFFVKDPEIRLPTITTVTVPAGYNWRDIVSYVLDHFSIEISGGLGPTEERVLR 361 Query: 361 IGLLGCNATRENVDRVTEALRAALQHCPKKKL 392 IGLLG NAT ENVDRV EALR ALQHCPK KL Sbjct: 362 IGLLGYNATTENVDRVAEALREALQHCPKNKL 393 >2HUU-A nrPDB Length = 393 Score = 371 bits (952), Expect = e-103, Method: Compositional matrix adjust. Identities = 181/377 (48%), Positives = 247/377 (65%), Gaps = 1/377 (0%) Query: 8 VTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYV 67 VTPP L +PL PN+LL+GPGPSN P R++ A ++G + + +IMD+IKEG++Y+ Sbjct: 5 VTPPAVLREPLVTPNKLLMGPGPSNAPQRVLDAMSRPILGHLHPETLKIMDDIKEGVRYL 64 Query: 68 FQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMT 127 FQT N T +S SGH +EA L N+LE GD L+G G WG R+ D+ R GA V + Sbjct: 65 FQTNNIATFCLSASGHGGMEATLCNLLEDGDVILIGHTGHWGDRSADMATRYGADVRVVK 124 Query: 128 KDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVAS 187 G +L E+ + L HKP +LFLT G+SSTGVLQ L+G G LCH++ CLL+VD+VAS Sbjct: 125 SKVGQSLSLDEIRDALLIHKPSVLFLTQGDSSTGVLQGLEGVGALCHQHNCLLIVDTVAS 184 Query: 188 LGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWL 247 LGG P++MDR ID +Y+GSQK L APPG + +SFS +A ++ R TK +Y D+ + Sbjct: 185 LGGAPMFMDRWEIDAMYTGSQKVLGAPPGITPVSFSHRAVERYKRRNTKVKVYYWDMSLV 244 Query: 248 ANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGL 307 ++WGC +PR+YHHTI LY LRE++A+ E+GL +H + A L+ LQ G Sbjct: 245 GDYWGCFGRPRIYHHTISSTLLYGLREAIAMACEEGLPALIARHEDCAKRLYRGLQDAGF 304 Query: 308 QLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCN 367 +L+ DP RL TVTT+ VP G DW Y + + +EI GGLGP+ G+V RIGL+G N Sbjct: 305 ELYA-DPKDRLSTVTTIKVPQGVDWLKAAQYAMKTYLVEISGGLGPTAGQVFRIGLMGQN 363 Query: 368 ATRENVDRVTEALRAAL 384 AT E VDRV + + A+ Sbjct: 364 ATTERVDRVLQVFQEAV 380 >2CH1-A nrPDB Length = 396 Score = 366 bits (939), Expect = e-101, Method: Compositional matrix adjust. Identities = 167/376 (44%), Positives = 252/376 (67%) Query: 10 PPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQ 69 PP +L PL IP ++++GPGPSN R++ A ++ + ++++ MDE+K+G++Y+FQ Sbjct: 6 PPASLRNPLIIPEKIMMGPGPSNCSKRVLTAMTNTVLSNFHAELFRTMDEVKDGLRYIFQ 65 Query: 70 TRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKD 129 T N T+ +SGS H +EA L N+LE GD L+ NGIW +RAV++ ER GA V + Sbjct: 66 TENRATMCVSGSAHAGMEAMLSNLLEEGDRVLIAVNGIWAERAVEMSERYGADVRTIEGP 125 Query: 130 PGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLG 189 P ++L+ + + H+P LFLTHG+SS+G+LQPL+G G++CH++ CLL+VD+VASL Sbjct: 126 PDRPFSLETLARAIELHQPKCLFLTHGDSSSGLLQPLEGVGQICHQHDCLLIVDAVASLC 185 Query: 190 GTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLAN 249 G P YMD+ ID +Y+G+QK L APPG + IS S KA + +R+TK FY D+ L N Sbjct: 186 GVPFYMDKWEIDAVYTGAQKVLGAPPGITPISISPKALDVIRNRRTKSKVFYWDLLLLGN 245 Query: 250 FWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQL 309 +WGC D+P+ YHHT+ +++LRE+LA IAE+GLEN ++ E A L+ L +GL + Sbjct: 246 YWGCYDEPKRYHHTVASNLIFALREALAQIAEEGLENQIKRRIECAQILYEGLGKMGLDI 305 Query: 310 FVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNAT 369 FVKDP RLPTVT + +P G DW + Y +++F +E+ GGLGP+ GK R+G++G +T Sbjct: 306 FVKDPRHRLPTVTGIMIPKGVDWWKVSQYAMNNFSLEVQGGLGPTFGKAWRVGIMGECST 365 Query: 370 RENVDRVTEALRAALQ 385 + + + +L+ Sbjct: 366 VQKIQFYLYGFKESLK 381 >1VJO-A nrPDB Length = 393 Score = 336 bits (861), Expect = 1e-92, Method: Compositional matrix adjust. Identities = 164/371 (44%), Positives = 244/371 (65%), Gaps = 4/371 (1%) Query: 15 LKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPL 74 L+PL +P++LLLGPGPSN P ++ A + +G + +MDEI+ ++YV+QT NPL Sbjct: 27 LEPLEVPSRLLLGPGPSNAHPSVLQAMNVSPVGHLDPAFLALMDEIQSLLRYVWQTENPL 86 Query: 75 TLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHY 134 T+ +SG+G A+EA + N +EPGD L+G G +G R VD+ R GA V ++K G + Sbjct: 87 TIAVSGTGTAAMEATIANAVEPGDVVLIGVAGYFGNRLVDMAGRYGADVRTISKPWGEVF 146 Query: 135 TLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLY 194 +L+E+ L H+P +L L H E+STG QPL+G GELC + LLLVD+V SLGG P++ Sbjct: 147 SLEELRTALETHRPAILALVHAETSTGARQPLEGVGELCREFGTLLLVDTVTSLGGVPIF 206 Query: 195 MDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCD 254 +D G+D+ YS SQK L PG S + S +A +K+ R+TK ++YLD+ L +WG + Sbjct: 207 LDAWGVDLAYSCSQKGLGCSPGASPFTMSSRAIEKLQRRRTKVANWYLDMNLLGKYWGSE 266 Query: 255 DQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDP 314 R+YHHT P+ Y+LRE+L LIA++GL N W++H++ YL RL+ +GL L V + Sbjct: 267 ---RVYHHTAPINLYYALREALRLIAQEGLANCWQRHQKNVEYLWERLEDIGLSLHV-EK 322 Query: 315 ALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVD 374 RLPT+TTV +P G D + + +++ +IE+ GGLG GKV R+GL+G N+ +E+VD Sbjct: 323 EYRLPTLTTVCIPDGVDGKAVARRLLNEHNIEVGGGLGELAGKVWRVGLMGFNSRKESVD 382 Query: 375 RVTEALRAALQ 385 ++ AL L+ Sbjct: 383 QLIPALEQVLR 393 >3ISL-A nrPDB Length = 416 Score = 222 bits (566), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 124/387 (32%), Positives = 201/387 (51%), Gaps = 22/387 (5%) Query: 16 KPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLT 75 + L P + ++ PGP + PR++ ++G IM+E E ++ +FQT+N Sbjct: 5 RELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTGIMNETMEMLRELFQTKNRWA 64 Query: 76 LVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYT 135 I G+ +EA L +V+EP D L+ G +G +I ER GA VH + + G + Sbjct: 65 YPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLTEIAERYGANVHMLECEWGTVFD 124 Query: 136 LQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYM 195 +++ + + KP ++ + HGE+STG + PL GE C L +VD+VA++GG + + Sbjct: 125 PEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGEACRTEDALFIVDAVATIGGCEVKV 184 Query: 196 DRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRK-----------------TKPF 238 D ID G+QK L+ P G + I+++++ + +RK +P Sbjct: 185 DEWKIDAAIGGTQKCLSVPSGMAPITYNERVADVIAARKKVERGIATQADRAALSGNRPI 244 Query: 239 -SFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAY 297 S Y D+ L ++W + R+ HHT LY+LRE + L+ E+GLE + +HR A Sbjct: 245 TSNYFDLSQLEDYW---SERRLNHHTEATTMLYALREGVRLVLEEGLETRFERHRHHEAA 301 Query: 298 LHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGK 357 L ++A+GL+LF D + ++P VT V +P G D + ++ F IEI GP GK Sbjct: 302 LAAGIKAMGLRLF-GDDSCKMPVVTCVEIPGGIDGESVRDMLLAQFGIEIASSFGPLAGK 360 Query: 358 VLRIGLLGCNATRENVDRVTEALRAAL 384 + RIG +G + +ENV V L A L Sbjct: 361 IWRIGTMGYSCRKENVLFVLAGLEAVL 387 >3NNK-A nrPDB Length = 411 Score = 218 bits (554), Expect = 5e-57, Method: Compositional matrix adjust. Identities = 131/385 (34%), Positives = 199/385 (51%), Gaps = 20/385 (5%) Query: 18 LSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLV 77 L+ P++LL+GPGP N PR++ A Q+IG M M+E+ + VF+T N T++ Sbjct: 9 LNPPSRLLMGPGPINADPRVLRAMSSQLIGQYDPAMTHYMNEVMALYRGVFRTENRWTML 68 Query: 78 ISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQ 137 + G+ +EA LV+ + PGD LV G +G +I R A VH + G +T Sbjct: 69 VDGTSRAGIEAILVSAIRPGDKVLVPVFGRFGHLLCEIARRCRAEVHTIEVPWGEVFTPD 128 Query: 138 EVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDR 197 +VE+ + + +P LL G++ST +LQPL GE+C RY L D+ ASLGG PL D Sbjct: 129 QVEDAVKRIRPRLLLTVQGDTSTTMLQPLAELGEICRRYDALFYTDATASLGGNPLETDV 188 Query: 198 QGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKP----------------FSFY 241 G+D + +G QK L P GTS I+ S + ++ + RK +S Y Sbjct: 189 WGLDAVSAGMQKCLGGPSGTSPITLSARMEEAIRRRKCVEEGIRTDAHRDGDEEMIYSNY 248 Query: 242 LDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGR 301 D+ + ++WG + R+ HHT +L+ RE LI ++GL+ +H+ L Sbjct: 249 FDLGMVMDYWGPE---RLNHHTEATTALFGARECARLILQEGLDYGIARHKLHGDALVKG 305 Query: 302 LQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRI 361 +QA+GL+ F D ++ V V +P G + +++ F IEI GP GKV RI Sbjct: 306 IQAMGLETF-GDLKHKMNNVLGVVIPQGINGDQARKLMLEDFGIEIGTSFGPLHGKVWRI 364 Query: 362 GLLGCNATRENVDRVTEALRAALQH 386 G +G NA ++ V AL A L + Sbjct: 365 GTMGYNARKDCVMTTLSALEAVLNY 389 >2YRI-A nrPDB Length = 353 Score = 179 bits (454), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 123/362 (33%), Positives = 187/362 (51%), Gaps = 14/362 (3%) Query: 24 LLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQT-RNPLTLVISGSG 82 LLL PGP+ +P R+ A M G + ++ ++ I+E + +F L ++GSG Sbjct: 2 LLLTPGPTPIPERVQKALLRPMRGHLDPEVLRVNRAIQERLAALFDPGEGALVAALAGSG 61 Query: 83 HCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEG 142 +EA L N L+ G LV NG + QR ++ G + PG + V Sbjct: 62 SLGMEAGLAN-LDRG-PVLVLVNGAFSQRVAEMAALHGLDPEVLDFPPGEPVDPEAVARA 119 Query: 143 LAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDI 202 L + + ++ L HGE+STGVL P + G L L +D+V +LG P M G+D Sbjct: 120 LKRRRYRMVALVHGETSTGVLNPAEAIGALAKEAGALFFLDAVTTLGMLPFSMRAMGVDY 179 Query: 203 LYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHH 262 ++GSQK L+APPG + I+ S +A+K ++ +YLD+ +A W YHH Sbjct: 180 AFTGSQKCLSAPPGLAPIAASLEARKAFTGKR----GWYLDLARVAEHWERGG----YHH 231 Query: 263 TIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVT 322 T PV+ Y+L E+L L+ E+G+ R+ RE A++ L+A G + + K A LPTV Sbjct: 232 TTPVLLHYALLEALDLVLEEGVAARERRAREVYAWVLEELKARGFRPYPK--ASPLPTVL 289 Query: 323 TVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRA 382 V P G D +V + + + GG+GP+ G+VLR+GL+G A RE +AL Sbjct: 290 VVRPPEGVDADRLVRALYAE-GVAVAGGIGPTRGQVLRLGLMGEGARREAYQAFLKALDR 348 Query: 383 AL 384 AL Sbjct: 349 AL 350 >3ZRR-A nrPDB Length = 384 Score = 140 bits (352), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 105/346 (30%), Positives = 184/346 (53%), Gaps = 7/346 (2%) Query: 22 NQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVF-QTRNPLTLVISG 80 ++LLL GP+ + ++ AG +G SK+ + + +G++YV ++N L+I G Sbjct: 2 DKLLLHVGPTTIKEDVLVAGLENNVGFTSKEFVEALAYSLKGLRYVMGASKNYQPLIIPG 61 Query: 81 SGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVE 140 G A+E+ + ++L+P D LV +NG++G R I +R V + PG + EVE Sbjct: 62 GGTSAMES-VTSLLKPNDKILVVSNGVFGDRWEQIFKRYPVNVKVLRPSPGDYVKPGEVE 120 Query: 141 EGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGI 200 E + + + L+ LTH E+STGV +P+ +Y L++VD V+S+G + + + Sbjct: 121 EEVRKSEYKLVALTHVETSTGVREPVKDVINKIRKYVELIVVDGVSSVGAEEVKAEEWNV 180 Query: 201 DILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIK-WLANFWGCDDQPRM 259 D+ + SQKAL + G L+ S KA + S+ + +YLD++ WL G ++ Sbjct: 181 DVYLTASQKALGSAAGLGLLLLSPKALSILDSQNSIA-GYYLDLRNWLPVMRGAEEGKAA 239 Query: 260 YHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLP 319 Y T PV + L E+ LI ++G+EN ++H A+ + L+ALGL++ + P Sbjct: 240 YFATPPVHVILQLAEAFRLIEKEGIENRIKRHTMVASAIRAGLEALGLEIVARRPESYSN 299 Query: 320 TVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLG 365 TVT V + D + +++ ++ +E G+ P+ K RIG +G Sbjct: 300 TVTGVILKVA-DPQKVLAGTVNE-GVEFAPGVHPAF-KYFRIGHMG 342 >2DR1-A nrPDB Length = 386 Score = 128 bits (321), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 93/376 (24%), Positives = 177/376 (47%), Gaps = 16/376 (4%) Query: 21 PNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISG 80 P L GP P ++ +QM SK+ ++ + E ++ + L++ Sbjct: 19 PKYKLFTAGPVACFPEVLEIMKVQMFSHRSKEYRKVHMDTVERLREFLEVEKGEVLLVPS 78 Query: 81 SGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVE 140 SG +EA++ N + G LV G +G+R ++ E G + + +PG ++++ Sbjct: 79 SGTGIMEASIRNGVSKGGKVLVTIIGAFGKRYKEVVESNGRKAVVLEYEPGKAVKPEDLD 138 Query: 141 EGLAQHKPV-LLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQG 199 + L ++ V + +T+ E+STGVL PL ++ + L+ VD+V+++GG + D+ G Sbjct: 139 DALRKNPDVEAVTITYNETSTGVLNPLPELAKVAKEHDKLVFVDAVSAMGGADIKFDKWG 198 Query: 200 IDILYSGSQKALNAPPGTSLISFSDK---AKKKMYSRKTKPFSFYLDIKWLANFWGCDDQ 256 +D+++S SQKA PPG ++ +FS++ +KM R +Y DI + + Sbjct: 199 LDVVFSSSQKAFGVPPGLAIGAFSERFLEIAEKMPER-----GWYFDIPLYVKYL---KE 250 Query: 257 PRMYHHTIPVISLYSLRESLALIAEQGLENSWRQ-HREAAAYLHGRLQALGLQLFVKDPA 315 T P+ ++ + +L +I + G + W + + + A + ++ +GL + +P Sbjct: 251 KESTPSTPPMPQVFGINVALRIIEKMGGKEKWLEMYEKRAKMVREGVREIGLDILA-EPG 309 Query: 316 LRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDR 375 PT+T V P G D V + E+ G G K RIG +G E++ Sbjct: 310 HESPTITAVLTPPGIKG-DEVYEAMRKRGFELAKGYGSVKEKTFRIGHMGY-MKFEDIQE 367 Query: 376 VTEALRAALQHCPKKK 391 + + LR + K+K Sbjct: 368 MLDNLREVINELKKQK 383 >2Z9W-A nrPDB Length = 392 Score = 114 bits (285), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 85/346 (24%), Positives = 153/346 (44%), Gaps = 5/346 (1%) Query: 24 LLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGH 83 + L GP N P ++ G ++ + +++ + Q + N +++ G Sbjct: 11 ITLTAGPVNAYPEVLRGLGRTVLYDYDPAFQLLYEKVVDKAQKAMRLSNK-PVILHGEPV 69 Query: 84 CALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGL 143 LEAA +++ P D L A+G++G+ +R + + Q V + L Sbjct: 70 LGLEAAAASLISPDDVVLNLASGVYGKGFGYWAKRYSPHLLEIEVPYNEAIDPQAVADML 129 Query: 144 AQHKPV-LLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDI 202 H + ++ + H ++ +G + P+D G L + L+VD+V+S GG + + DI Sbjct: 130 KAHPEITVVSVCHHDTPSGTINPIDAIGALVSAHGAYLIVDAVSSFGGMKTHPEDCKADI 189 Query: 203 LYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHH 262 +G K L APPG +++ S++A KM + P + L I N W D + + Sbjct: 190 YVTGPNKCLGAPPGLTMMGVSERAWAKMKANPLAPRASMLSIVDWENAWSRD---KPFPF 246 Query: 263 TIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVT 322 T V + L +L L +G E W +H A + + A+GL ++ ++ PT T Sbjct: 247 TPSVSEINGLDVALDLYLNEGPEAVWARHALTAKAMRAGVTAMGLSVWAASDSIASPTTT 306 Query: 323 TVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNA 368 V P G D + + + + G G + GK+ RIG +G A Sbjct: 307 AVRTPDGVDEKALRQAARARYGVVFSSGRGETLGKLTRIGHMGPTA 352 >1M32-A nrPDB Length = 366 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 85/319 (26%), Positives = 146/319 (45%), Gaps = 17/319 (5%) Query: 22 NQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQI--MDEIKEGIQYVFQTRNPLTLVI- 78 N LLL PGP + A + D Y I +++I++ + + T V+ Sbjct: 4 NYLLLTPGPLTTSRTVKEA--MLFDSCTWDDDYNIGVVEQIRQQLTALATASEGYTSVLL 61 Query: 79 SGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQE 138 GSG A+EA L + L P D L+ +NG +G R V++ +G H +Q Sbjct: 62 QGSGSYAVEAVLGSALGPQDKVLIVSNGAYGARMVEMAGLMGIAHHAYDCGEVARPDVQA 121 Query: 139 VEEGLAQHKPVL--LFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMD 196 ++ + P + + + H E++TG+L P+D G L HRY +VD+++S GG P+ + Sbjct: 122 ID-AILNADPTISHIAMVHSETTTGMLNPIDEVGALAHRYGKTYIVDAMSSFGGIPMDIA 180 Query: 197 RQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGC-DD 255 ID L S + K + PG +F ++K+ + K S LD L W C +D Sbjct: 181 ALHIDYLISSANKCIQGVPG---FAFVIAREQKLAACKGHSRSLSLD---LYAQWRCMED 234 Query: 256 QPRMYHHTIPVISLYSLRESLALIA-EQGLENSWRQHREAAAYLHGRLQALGLQLFVKDP 314 + T P ++ + ++L +A E G+ +++++ L ++ALG + D Sbjct: 235 NHGKWRFTSPTHTVLAFAQALKELAKEGGVAARHQRYQQNQRSLVAGMRALGFNTLLDDE 294 Query: 315 ALRLPTVTTVAVPAGYDWR 333 L P +T P +R Sbjct: 295 -LHSPIITAFYSPEDPQYR 312 >2BKW-A nrPDB Length = 385 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 97/367 (26%), Positives = 159/367 (43%), Gaps = 25/367 (6%) Query: 25 LLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQT---RNPLTLVISGS 81 LL PGP L + A + +G S + I + + + VF++ V++GS Sbjct: 8 LLIPGPIILSGAVQKALDVPSLGHTSPEFVSIFQRVLKNTRAVFKSAAASKSQPFVLAGS 67 Query: 82 GHCALEAALVNVL---EPGDSFLVGANGIWGQRAVDIGERIGARVHPMTK-DPGGHYTLQ 137 G + N + P + LV + G + R D GA+V + G L+ Sbjct: 68 GTLGWDIFASNFILSKAPNKNVLVVSTGTFSDRFADCLRSYGAQVDVVRPLKIGESVPLE 127 Query: 138 EVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRY--KCLLLVDSVASLGGTPLYM 195 + E L+Q+ + +TH ++ST VL L + + + +VD+V S+G Sbjct: 128 LITEKLSQNSYGAVTVTHVDTSTAVLSDLKAISQAIKQTSPETFFVVDAVCSIGCEEFEF 187 Query: 196 DRQGIDILYSGSQKALNAPPGTSL----ISFSDKAKKKMYSRKTKPFSFYLDI-KWLANF 250 D G+D + SQKA+ AP G S+ F D A S+ ++ + +W Sbjct: 188 DEWGVDFALTASQKAIGAPAGLSISLCSSRFMDYALND--SKNGHVHGYFSSLRRWTPIM 245 Query: 251 WGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLF 310 + Y T PV + SL +L I E+GL W HRE + + L GLQL Sbjct: 246 ENYEAGKGAYFATPPVQLINSLDVALKEILEEGLHKRWDLHREMSDWFKDSL-VNGLQL- 303 Query: 311 VKDPALRLPT-VTTVAVPAGY--DWRDIVSYVIDHFDIEIMGGLGPSTG-KVLRIGLLGC 366 R P+ ++ + A Y D D+++++ H + I GG+ G K +RIG +G Sbjct: 304 --TSVSRYPSNMSAHGLTAVYVADPPDVIAFLKSH-GVVIAGGIHKDIGPKYIRIGHMGV 360 Query: 367 NATRENV 373 A +N+ Sbjct: 361 TACNKNL 367 >1IUG-A nrPDB Length = 352 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 94/350 (26%), Positives = 149/350 (42%), Gaps = 33/350 (9%) Query: 25 LLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHC 84 LL PGP L P+ + A + ++ ++ + + ++ F+T + L+++GSG Sbjct: 4 LLTPGPVRLHPKALEALARPQLHHRTEAAREVFLKARGLLREAFRTEGEV-LILTGSGTL 62 Query: 85 ALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEV-EEGL 143 A+EA + N+ PG+ LV G + +R +I G V + G ++V +EG Sbjct: 63 AMEALVKNLFAPGERVLVPVYGKFSERFYEIALEAGLVVERLDYPYGDTPRPEDVAKEGY 122 Query: 144 AQHKPVLLFLTHGESSTGVLQPLDGFGELCHRY--KCLLLVDSVASLGGTPLYMDRQGID 201 A L L H E+STG L L + L+ D V SL + ++ G+D Sbjct: 123 AG-----LLLVHSETSTGALADLPALARAFKEKNPEGLVGADMVTSLLVGEVALEAMGVD 177 Query: 202 ILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYH 261 SGSQK L PPG ++ S +A +++ KP +YLD+ Q Sbjct: 178 AAASGSQKGLMCPPGLGFVALSPRALERL-----KPRGYYLDLA-----RELKAQKEGES 227 Query: 262 HTIPVISLY-----SLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPAL 316 P I+L L E L + E +W+ A L+G + GL+ P Sbjct: 228 AWTPAINLVLAVAAVLEEVLPRLEEHLALKAWQN-----ALLYGVGEEGGLR---PVPKR 279 Query: 317 RLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGC 366 P V +P G + + + I GG GP GKV R+ L+G Sbjct: 280 FSPAVAAFYLPEGVPYARVKEAFAQRGAV-IAGGQGPLKGKVFRLSLMGA 328 >3KE3-A nrPDB Length = 379 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 68/258 (26%), Positives = 120/258 (46%), Gaps = 23/258 (8%) Query: 44 QMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVG 103 + + MSK ++M+++ ++ V+ ++I GSG +EA + L + L+ Sbjct: 24 RALNHMSKAFQEVMNDLLSNLKTVYNAE--AAVIIPGSGTYGMEA-VARQLTIDEDCLII 80 Query: 104 ANGIWGQRAVDIGER---------IGARVHPMTKDPGGHYTLQEVEEGLA---QHKPVLL 151 NG + R I E+ + A T+ P + ++E +A + K ++ Sbjct: 81 RNGWFSYRWTQILEKGKFAKSSTVLTAERTEDTEAPK-PFAPVDIETAVAKIKEDKSAIV 139 Query: 152 FLTHGESSTGVL---QPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQ 208 + H E+S+G++ + + E H LL++D +AS G L M GID+L S Q Sbjct: 140 YAPHVETSSGIILSEEYIKALSEAVHSVGGLLVIDCIAS-GCVWLDMKELGIDVLISAPQ 198 Query: 209 KALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIK-WLANFWGCDDQPRMYHHTIPVI 267 K ++ P L+ S A KK+ S ++ FS LD+K WL ++ YH T+P Sbjct: 199 KGWSSTPCAGLVMLSAAAIKKVESTESNCFS--LDLKQWLTIMRAYENGGHAYHATMPTD 256 Query: 268 SLYSLRESLALIAEQGLE 285 SL R+++ E G + Sbjct: 257 SLRQFRDAILEAKEIGFD 274 >3FFR-A nrPDB Length = 362 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 80/377 (21%), Positives = 152/377 (40%), Gaps = 33/377 (8%) Query: 22 NQLLLGPGPSNLPPRI---MAAGGLQMIGSMS---KDMYQIMDEIKEGIQYVFQTRNPLT 75 N++ PGPS L P + M + IG +S K ++ + ++ + + + Sbjct: 4 NKIYFTPGPSELYPTVRQHMITALDEKIGVISHRSKKFEEVYKTASDNLKTLLELPSNYE 63 Query: 76 LVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPG-GHY 134 ++ S E + N +E V NG + +R + +G + G G Y Sbjct: 64 VLFLASATEIWERIIQNCVEKKSFHCV--NGSFSKRFYEFAGELGREAYKEEAAFGKGFY 121 Query: 135 TLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYK-CLLLVDSVASLGGTPL 193 A+ ++ LTH E+S+GV P++ + K L+ VD+V+SL P Sbjct: 122 PADITVPADAE----IICLTHNETSSGVSMPVEDINTFRDKNKDALIFVDAVSSL-PYPK 176 Query: 194 YMDRQGIDILYSGSQKALNAPPGTSLISFSDKA--KKKMYSRKTKPFSFYLDIKWLANFW 251 + D ID ++ QK P G + +D+ K K K K Y I + Sbjct: 177 F-DWTKIDSVFFSVQKCFGLPAGLGVWILNDRVIEKSKALLAKRKSIGTYHTIPSMLEKA 235 Query: 252 GCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLF- 310 + P + + + L + + I+ G+ +Q E AA ++ +++ + F Sbjct: 236 RVNQTPET-PNAMNIFLLGKVTGDMLQISADGIR---KQTEEKAALINTYIESSKVFSFG 291 Query: 311 VKDPALRLPTV---TTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCN 367 V+D LR T T +P ++ +++ FD+ + G G +RI + Sbjct: 292 VEDAKLRSMTTIVANTTMLPGE------INKILEPFDMAVGAGYGSKKETQIRIANFPAH 345 Query: 368 ATRENVDRVTEALRAAL 384 + E V ++ + L+ + Sbjct: 346 SL-EQVHKLVQTLKEKI 361 >3LVM-A nrPDB Length = 423 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 27/114 (23%), Positives = 53/114 (46%), Gaps = 2/114 (1%) Query: 117 ERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRY 176 ER G V + G L+E+E + + +L+ + H + GV+Q + GE+C Sbjct: 134 EREGFEVTYLAPQRNGIIDLKELEAAM-RDDTILVSIMHVNNEIGVVQDIAAIGEMCRAR 192 Query: 177 KCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKM 230 + VD+ S+G P+ + + +D++ S S + P G + K + ++ Sbjct: 193 GIIYHVDATQSVGKLPIDLSQLKVDLM-SFSGHKIYGPKGIGALYVRRKPRVRI 245 >5WT2-A nrPDB Length = 401 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 25/100 (25%), Positives = 47/100 (47%), Gaps = 2/100 (2%) Query: 117 ERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRY 176 E +G V + + G T ++V E + + K L+ + + TG++ P++ G +C Sbjct: 115 ESLGVEVTYLPINEHGSITAEQVREAITE-KTALVSVMWANNETGLIFPIEEIGAICKEK 173 Query: 177 KCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPG 216 L D+V ++G P+ + + D L S S + P G Sbjct: 174 GVLFHTDAVQAIGKIPVDVLKANADFL-SFSAHKFHGPKG 212 >3TQX-A nrPDB Length = 399 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 53/186 (28%), Positives = 81/186 (43%), Gaps = 41/186 (22%) Query: 136 LQEVEEGLAQHKPVLLFLTHGE-SSTGVLQPLDGFGELCHRYKCLLLVDSVASLG----- 189 L+E +E A+ K L T G S G++ L +L +Y L++VD ++G Sbjct: 166 LKEADEKGARFK---LIATDGVFSMDGIIADLKSICDLADKYNALVMVDDSHAVGFIGEN 222 Query: 190 --GTPLY---MDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDI 244 GTP Y DR +DIL KAL G Y+ K I Sbjct: 223 GRGTPEYCGVADR--VDILTGTLGKALGGASGG-------------YTSGHKEI-----I 262 Query: 245 KWLANFWGCDDQPRMYHHTI-PVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQ 303 +WL N +P ++ +T+ PVI SL+ L L+ +G + +Q +E + Y ++ Sbjct: 263 EWLRN----RSRPYLFSNTVAPVIVATSLK-VLELLKTEGPQ-LRKQLQENSRYFRAGME 316 Query: 304 ALGLQL 309 LG QL Sbjct: 317 KLGFQL 322 >4W91-A nrPDB Length = 422 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 71/282 (25%), Positives = 117/282 (41%), Gaps = 26/282 (9%) Query: 115 IGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCH 174 I ER GA++ D G + ++E E+ L++ + L+ +TH ++ G + P+ EL H Sbjct: 149 IRERQGAKLVFTPVDDNGVFHIEEFEKRLSE-RTKLVAITHMSNTLGTVVPIKKIVELAH 207 Query: 175 RYKCLLLVDSVASLGGTPLYMDRQ--GIDILYSGSQKALNAPPGTSLISFSDKAKKKMYS 232 +LVD S G L +D Q G D Y + + P G ++ + +KM Sbjct: 208 ARGIPVLVD--GSQGAVHLPVDVQDLGCD-WYVFTGHKVYGPSGIGVLYGRAQMLEKM-- 262 Query: 233 RKTKPFSFYLD-IKWLANFWGCDDQP--RMYHHTIPVISLYSLRESLALIAEQGLENSWR 289 +PF + I+ + + P R T P++ L +L + + G Sbjct: 263 ---RPFQGGGEMIEEVTEENVTYNHPPHRFEAGTPPIVQAIGLGAALEYMEKIGRHAILA 319 Query: 290 QHREAAAYLHGRLQALG-LQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIM 348 + Y H RL + L++F P + + A+ G D VS VID + + Sbjct: 320 HEADLRDYAHERLGRINSLRIFGNAP--DKGAIISFALE-GIHAHD-VSMVIDRAGVAVR 375 Query: 349 GGLGPSTGKVLRIGLLG-CNA------TRENVDRVTEALRAA 383 G + + R G+ C A TR VD + EAL A Sbjct: 376 AGTHCAQPLLKRFGVTSTCRASFALYNTRAEVDALAEALEKA 417 >2E7J-A nrPDB Length = 371 Score = 36.2 bits (82), Expect = 0.024, Method: Compositional matrix adjust. Identities = 19/77 (24%), Positives = 37/77 (48%) Query: 137 QEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMD 196 Q +EE + + VL +T+ + + G L + ++C Y LLV+ ++G P+ + Sbjct: 137 QTIEETKKRGEVVLALITYPDGNYGNLPDVKKIAKVCSEYDVPLLVNGAYAIGRMPVSLK 196 Query: 197 RQGIDILYSGSQKALNA 213 G D + K++ A Sbjct: 197 EIGADFIVGSGHKSMAA 213 >4Q6R-A nrPDB Length = 511 Score = 36.2 bits (82), Expect = 0.025, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 24/100 (24%) Query: 161 GVLQPLDGFGELCHRYKCLLLVDSVASLGGT--------------PLYMDRQGIDILYSG 206 GV+ P+ +L +YK L VD A LGG P +G+ + + Sbjct: 236 GVIDPVPEVAKLAVKYKIPLHVD--ACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISAD 293 Query: 207 SQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKW 246 + K AP G+SL+ +SDK K + + F++D W Sbjct: 294 THKYGYAPKGSSLVLYSDK--------KYRNYQFFVDTDW 325 >1QZ9-A nrPDB Length = 416 Score = 36.2 bits (82), Expect = 0.026, Method: Compositional matrix adjust. Identities = 22/81 (27%), Positives = 36/81 (44%), Gaps = 1/81 (1%) Query: 137 QEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMD 196 +E+ + + Q V++ LTH TG + + L H L + D S G P+ + Sbjct: 156 EELPQAIDQDTAVVM-LTHVNYKTGYMHDMQALTALSHECGALAIWDLAHSAGAVPVDLH 214 Query: 197 RQGIDILYSGSQKALNAPPGT 217 + G D + K LN PG+ Sbjct: 215 QAGADYAIGCTYKYLNGGPGS 235 >6ENZ-A nrPDB Length = 530 Score = 35.8 bits (81), Expect = 0.033, Method: Compositional matrix adjust. Identities = 38/128 (29%), Positives = 55/128 (42%), Gaps = 17/128 (13%) Query: 123 VHPMTKDPGGHYTLQEVEEGLAQHK-----PVLLFLTHGESSTGVLQPLDGFGELCHRYK 177 V+ + D G +++E+ + Q + P L+ T G + G PLD E+C R+ Sbjct: 245 VYFVETDGRGKMIPEDLEKQIWQARQEGAVPFLVCATSGTTVLGAFDPLDEIAEVCERHG 304 Query: 178 CLLLVDSVASLGGTPLYMDR-----QGI---DILYSGSQKALNAPPGTSLISFSDKAK-- 227 L VD AS GG+ L + GI D + K L A S + DK+ Sbjct: 305 LWLHVD--ASWGGSALVSRKHRRLLHGIHRADSVAWNPHKMLMAGIQCSALLVKDKSDLL 362 Query: 228 KKMYSRKT 235 KK YS K Sbjct: 363 KKCYSAKA 370 >6MRE-A nrPDB Length = 420 Score = 35.0 bits (79), Expect = 0.054, Method: Compositional matrix adjust. Identities = 33/115 (28%), Positives = 51/115 (44%), Gaps = 6/115 (5%) Query: 118 RIGARVHPMTKDPGGHYTLQ-EVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRY 176 R+GA + + +P G TLQ E L K LL +TH + G PL L H++ Sbjct: 150 RVGAELRVIPLNPDG--TLQLETLPTLFDEKTRLLAITHVSNVLGTENPLAEMITLAHQH 207 Query: 177 KCLLLVDSVASLGGTPLYMDRQGIDI-LYSGSQKALNAPPGTSLISFSDKAKKKM 230 +LVD ++ P+ D Q +D Y S L P G ++ + ++M Sbjct: 208 GAKVLVDGAQAVMHHPV--DVQALDCDFYVFSGHKLYGPTGIGILYVKEALLQEM 260 >4MY5-A nrPDB Length = 393 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 34/132 (25%), Positives = 57/132 (43%), Gaps = 10/132 (7%) Query: 60 IKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERI 119 +KE + N + + I + AL A+L +LEPGD L+ A G V + Sbjct: 82 VKEKYHLTYNPDNEILVTIGATE--ALSASLTAILEPGDKVLLPAPAYPGYEPV--VNLV 137 Query: 120 GARVHPM-TKDPGGHYTLQEVEEGLAQHKPVL--LFLTHGESSTGVL---QPLDGFGELC 173 GA V + T+ T + +EE + + L + L + + TGV Q + E+ Sbjct: 138 GAEVVEIDTRSNDFVLTPEMLEEAILKEGEALKAVILNYPTNPTGVTYSRQQIKNLAEVL 197 Query: 174 HRYKCLLLVDSV 185 +Y ++ D V Sbjct: 198 KKYPIFVISDEV 209 >4U5I-A nrPDB Length = 403 Score = 33.1 bits (74), Expect = 0.22, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 25/48 (52%) Query: 57 MDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGA 104 +D++ I + + NP +VI G G+ LVN+ P D +L+G Sbjct: 219 IDDMNSRILKIIRKTNPTRIVIIGGGYWNSYNTLVNIKIPDDPYLIGT 266 >1FC4-A nrPDB Length = 401 Score = 32.7 bits (73), Expect = 0.26, Method: Compositional matrix adjust. Identities = 32/114 (28%), Positives = 53/114 (46%), Gaps = 14/114 (12%) Query: 136 LQEVEEGLAQHKPVLLFLTHGE-SSTGVLQPLDGFGELCHRYKCLLLVDSVASLG----- 189 L+E E A+H +L T G S GV+ L G +L +Y L++VD ++G Sbjct: 168 LKEAREAGARH---VLIATDGVFSMDGVIANLKGVCDLADKYDALVMVDDSHAVGFVGEN 224 Query: 190 --GTPLYMDRQG-IDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF 240 G+ Y D G +DI+ KAL G + + K + ++++P+ F Sbjct: 225 GRGSHEYCDVMGRVDIITGTLGKALGGASGG--YTAARKEVVEWLRQRSRPYLF 276 >5WGB-A nrPDB Length = 426 Score = 32.3 bits (72), Expect = 0.34, Method: Compositional matrix adjust. Identities = 24/99 (24%), Positives = 44/99 (44%), Gaps = 2/99 (2%) Query: 132 GHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGT 191 G L+E+E + Q L+ + + GV QP+ G +C K D+ ++G Sbjct: 151 GIIDLKELEAAI-QPDTSLVSVMTVNNEIGVKQPIAEIGRICSSRKVYFHTDAAQAVGKI 209 Query: 192 PLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKM 230 PL ++ ID++ S S + P G I + + ++ Sbjct: 210 PLDVNDMKIDLM-SISGHKIYGPKGVGAIYIRRRPRVRV 247 >4EB7-A nrPDB Length = 382 Score = 32.0 bits (71), Expect = 0.44, Method: Compositional matrix adjust. Identities = 20/79 (25%), Positives = 40/79 (50%), Gaps = 2/79 (2%) Query: 149 VLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQ 208 +L+ + H + G +QP++ E+ K L +D+ AS+G + +++ G D+L + S Sbjct: 140 ILVSVQHANNEIGTIQPVEEISEVLAG-KAALHIDATASVGQIEVDVEKIGADML-TISS 197 Query: 209 KALNAPPGTSLISFSDKAK 227 + P G + +AK Sbjct: 198 NDIYGPKGVGALWIRKEAK 216 >3HQT-A nrPDB Length = 409 Score = 31.6 bits (70), Expect = 0.64, Method: Compositional matrix adjust. Identities = 19/70 (27%), Positives = 29/70 (41%) Query: 120 GARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCL 179 GAR P H + + +H P ++ + S+ G + PL + + C Sbjct: 159 GARYANAQAHPFMHNNCDHLRMLIQRHGPGIIVVDSIYSTLGTIAPLAELVNISKEFGCA 218 Query: 180 LLVDSVASLG 189 LLVD SLG Sbjct: 219 LLVDESHSLG 228 >2JIS-A nrPDB Length = 515 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 37/76 (48%), Gaps = 7/76 (9%) Query: 123 VHPMTKDPGGHYTLQEVEE--GLAQHK---PVLLFLTHGESSTGVLQPLDGFGELCHRYK 177 V + D G +++E G+A+ + P L+ T G + G PL+ ++C R+ Sbjct: 230 VRVVKADERGKMVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHG 289 Query: 178 CLLLVDSVASLGGTPL 193 L VD A+ GG+ L Sbjct: 290 LWLHVD--AAWGGSVL 303 >5HH9-A nrPDB Length = 390 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 42/185 (22%), Positives = 77/185 (41%), Gaps = 16/185 (8%) Query: 51 KDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVL-EPGDSFLVGANGIWG 109 +++++ DE + F + P + ++GS L A +L +PG L ++ + Sbjct: 55 EEIWKYEDEARAWAGRYFAVQ-PGQVALTGSTTDGLAAIYGGLLVQPGKEILTSSHEHYS 113 Query: 110 QRAV--DIGERIGARVH--PMTKDPGGHYTLQEVEEGLAQHKPV--LLFLTHGESSTGVL 163 +R+G +V P+ KDP + + AQ +P +L +T +S +GV Sbjct: 114 TYTTLEYRHKRMGTQVREFPLFKDPHRVSADEILSSIAAQIRPQTRVLGMTWVQSGSGVK 173 Query: 164 QPLDGFGELCHRY--------KCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPP 215 P+ G+L + + +VD V G + D +G+ K L P Sbjct: 174 LPIREIGKLVRELNQKRDEQDRIIYVVDGVHGFGVEDVSFADFDCDYFIAGTHKWLFGPR 233 Query: 216 GTSLI 220 GT +I Sbjct: 234 GTGVI 238 >1T3I-A nrPDB Length = 420 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 24/106 (22%), Positives = 47/106 (44%), Gaps = 2/106 (1%) Query: 115 IGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCH 174 + + GA + + D + L+ + L++ K L+ + H ++ G + P + +L H Sbjct: 138 VAAKTGAVLKFVQLDEQESFDLEHFKTLLSE-KTKLVTVVHISNTLGCVNPAEEIAQLAH 196 Query: 175 RYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLI 220 + +LVD+ S PL + D L + K + AP G + Sbjct: 197 QAGAKVLVDACQSAPHYPLDVQLIDCDWLVASGHK-MCAPTGIGFL 241 >5O5C-A nrPDB Length = 519 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 1/54 (1%) Query: 137 QEVEEGLAQH-KPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLG 189 QEV+ L Q PV + T G + G + PL ELC + + VD+ G Sbjct: 251 QEVQRCLQQGLIPVAVVATSGTTDFGSIDPLGAISELCKHHGMWMHVDAAYGCG 304 >3NIZ-A nrPDB Length = 311 Score = 29.3 bits (64), Expect = 3.3, Method: Compositional matrix adjust. Identities = 18/58 (31%), Positives = 31/58 (53%), Gaps = 2/58 (3%) Query: 49 MSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANG 106 M KD+ +++DE K G+Q Q + L ++ G HC L L+P + L+ ++G Sbjct: 101 MEKDLKKVLDENKTGLQDS-QIKIYLYQLLRGVAHCHQHRILHRDLKP-QNLLINSDG 156 >2JPD-A nrPDB Length = 135 Score = 28.5 bits (62), Expect = 5.6, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 9/51 (17%) Query: 287 SWRQHREAAAYLHGRLQALG---------LQLFVKDPALRLPTVTTVAVPA 328 S R H Y+HGRLQ+LG +Q+ VKDP L + + + A Sbjct: 48 SLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDPQQALKELAKMCILA 98 >2JNW-A nrPDB Length = 133 Score = 28.5 bits (62), Expect = 5.7, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 9/51 (17%) Query: 287 SWRQHREAAAYLHGRLQALG---------LQLFVKDPALRLPTVTTVAVPA 328 S R H Y+HGRLQ+LG +Q+ VKDP L + + + A Sbjct: 61 SLRYHNLHPDYIHGRLQSLGKNFALRVLLVQVDVKDPQQALKELAKMCILA 111 >3WY7-A nrPDB Length = 404 Score = 27.7 bits (60), Expect = 8.2, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 17/32 (53%) Query: 158 SSTGVLQPLDGFGELCHRYKCLLLVDSVASLG 189 S+ G L PL +C R+ LLLVD LG Sbjct: 197 SADGDLAPLRDLHAVCRRHGALLLVDEAHGLG 228 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5LUC-A nrPDB 554 e-158 3KGX-A nrPDB 535 e-153 2CH1-A nrPDB 495 e-140 2HUU-A nrPDB 481 e-136 1VJO-A nrPDB 467 e-132 3ISL-A nrPDB 434 e-122 3NNK-A nrPDB 426 e-120 2DR1-A nrPDB 364 e-101 2Z9W-A nrPDB 350 6e-97 2YRI-A nrPDB 349 1e-96 3ZRR-A nrPDB 325 2e-89 2BKW-A nrPDB 319 1e-87 1M32-A nrPDB 292 1e-79 1IUG-A nrPDB 276 1e-74 3FFR-A nrPDB 275 2e-74 3KE3-A nrPDB 237 8e-63 3LVM-A nrPDB 130 7e-31 Sequences not found previously or not previously below threshold: 3VOM-A nrPDB 115 4e-26 5WGB-A nrPDB 102 3e-22 1T3I-A nrPDB 94 1e-19 5WT2-A nrPDB 93 1e-19 4W91-A nrPDB 92 5e-19 6MRE-A nrPDB 87 1e-17 6CZY-A nrPDB 87 1e-17 5XT5-A nrPDB 87 1e-17 2BIG-A nrPDB 83 2e-16 1ECX-A nrPDB 80 2e-15 2C0R-A nrPDB 76 2e-14 3QBO-A nrPDB 76 4e-14 4EB7-A nrPDB 74 1e-13 5F8V-A nrPDB 73 2e-13 3M5U-A nrPDB 72 3e-13 4Q75-A nrPDB 72 5e-13 5YD2-A nrPDB 71 8e-13 5HH9-A nrPDB 70 2e-12 4XK1-A nrPDB 69 2e-12 1QZ9-A nrPDB 69 3e-12 1BJO-A nrPDB 66 3e-11 4ISY-A nrPDB 64 9e-11 4MY5-A nrPDB 64 1e-10 3QM2-A nrPDB 62 4e-10 1V2E-A nrPDB 61 6e-10 4LW2-A nrPDB 61 7e-10 5YII-A nrPDB 61 7e-10 3AEO-A nrPDB 55 5e-08 3A9Z-A nrPDB 53 2e-07 6HRH-B nrPDB 53 2e-07 1M6S-A nrPDB 53 2e-07 6ENZ-A nrPDB 52 5e-07 3TQX-A nrPDB 50 2e-06 5V1X-E nrPDB 49 2e-06 3GZD-A nrPDB 49 3e-06 6EEI-A nrPDB 49 4e-06 4P3M-A nrPDB 49 5e-06 2CB1-A nrPDB 48 8e-06 1FC4-A nrPDB 48 8e-06 2CTZ-A nrPDB 46 2e-05 2JIS-A nrPDB 45 6e-05 3VK2-A nrPDB 45 6e-05 3CAI-A nrPDB 44 1e-04 3HQT-A nrPDB 44 2e-04 4Q6R-A nrPDB 43 2e-04 5K8B-A nrPDB 42 3e-04 2OKK-A nrPDB 42 5e-04 3EUC-A nrPDB 42 5e-04 4RIT-B nrPDB 42 7e-04 1SVV-A nrPDB 39 0.003 4BMK-A nrPDB 39 0.003 4J5U-A nrPDB 39 0.005 4OBV-D nrPDB 38 0.006 5O5C-A nrPDB 37 0.010 3ASB-A nrPDB 37 0.013 1M4N-A nrPDB 37 0.015 6HNB-A nrPDB 37 0.015 3G8M-A nrPDB 37 0.015 1IAY-A nrPDB 37 0.017 3E9K-A nrPDB 37 0.017 3DYD-A nrPDB 37 0.019 6EEQ-A nrPDB 37 0.020 4FL0-A nrPDB 37 0.020 3WY7-A nrPDB 36 0.024 4PPM-A nrPDB 36 0.026 5YKR-A nrPDB 36 0.026 3PDX-A nrPDB 36 0.027 3MAF-B nrPDB 35 0.052 1JS3-A nrPDB 35 0.077 3N0L-A nrPDB 35 0.079 2GB3-A nrPDB 34 0.088 4IYO-A nrPDB 34 0.11 2X8U-A nrPDB 34 0.11 5EAV-A nrPDB 34 0.14 1XI9-A nrPDB 34 0.16 4J8L-A nrPDB 34 0.16 1HC1-A nrPDB 33 0.26 6EEM-B nrPDB 33 0.29 3X2F-A nrPDB 32 0.41 5LH9-A nrPDB 32 0.55 4FNP-A nrPDB 32 0.58 2EEO-B nrPDB 31 0.81 3CLR-D nrPDB 31 1.0 3CQ5-A nrPDB 30 1.5 1AL3-A nrPDB 30 1.6 4DG5-A nrPDB 30 1.7 4BQ0-A nrPDB 30 2.0 1B4N-A nrPDB 30 2.1 3GD5-A nrPDB 30 2.5 2C2Q-A nrPDB 29 4.6 6GFF-I nrPDB 29 4.9 4MHX-A nrPDB 29 5.2 2V7B-A nrPDB 28 5.9 3SI2-A nrPDB 28 6.0 2X4L-A nrPDB 28 6.9 4ZM4-A nrPDB 28 7.3 >5LUC-A nrPDB Length = 403 Score = 554 bits (1428), Expect = e-158, Method: Composition-based stats. Identities = 391/392 (99%), Positives = 392/392 (100%) Query: 1 MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI 60 MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI Sbjct: 12 MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI 71 Query: 61 KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG 120 KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG Sbjct: 72 KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG 131 Query: 121 ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL 180 ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL Sbjct: 132 ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL 191 Query: 181 LVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF 240 LV+SVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF Sbjct: 192 LVNSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF 251 Query: 241 YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG 300 YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG Sbjct: 252 YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG 311 Query: 301 RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR 360 RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR Sbjct: 312 RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR 371 Query: 361 IGLLGCNATRENVDRVTEALRAALQHCPKKKL 392 IGLLGCNATRENVDRVTEALRAALQHCPKKKL Sbjct: 372 IGLLGCNATRENVDRVTEALRAALQHCPKKKL 403 >3KGX-A nrPDB Length = 393 Score = 535 bits (1379), Expect = e-153, Method: Composition-based stats. Identities = 301/392 (76%), Positives = 338/392 (86%) Query: 1 MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI 60 M S++LLV PP+AL KPLS+P +LLLGPGPSNL PR++AAG L+MIG M K+M QIM+EI Sbjct: 2 MGSYQLLVPPPEALSKPLSVPTRLLLGPGPSNLAPRVLAAGSLRMIGHMQKEMLQIMEEI 61 Query: 61 KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG 120 K+GIQYVFQTRNPLTLV+SGSGHCA+E AL N+LEPGDSFL G NGIWG RA +I +RIG Sbjct: 62 KQGIQYVFQTRNPLTLVVSGSGHCAMETALFNLLEPGDSFLTGTNGIWGMRAAEIADRIG 121 Query: 121 ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL 180 ARVH M K PG HYTLQEVEEGLAQHKPVLLFL HGESSTGV+QPLDGFGELCHRY+CLL Sbjct: 122 ARVHQMIKKPGEHYTLQEVEEGLAQHKPVLLFLVHGESSTGVVQPLDGFGELCHRYQCLL 181 Query: 181 LVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF 240 LVDSVASLGG P+YMD+QGIDI+YS SQK LNAPPG SLISF+DKAK K+YSRKTKP SF Sbjct: 182 LVDSVASLGGVPIYMDQQGIDIMYSSSQKVLNAPPGISLISFNDKAKYKVYSRKTKPVSF 241 Query: 241 YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG 300 Y DI +LA WGC+ + R+ HHT PV SLY LRESLALIAEQGLEN WR+HREA A+LH Sbjct: 242 YTDITYLAKLWGCEGETRVIHHTTPVTSLYCLRESLALIAEQGLENCWRRHREATAHLHK 301 Query: 301 RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR 360 LQ +GL+ FVKDP +RLPT+TTV VPAGY+WRDIVSYV+DHF IEI GGLGP+ +VLR Sbjct: 302 HLQEMGLKFFVKDPEIRLPTITTVTVPAGYNWRDIVSYVLDHFSIEISGGLGPTEERVLR 361 Query: 361 IGLLGCNATRENVDRVTEALRAALQHCPKKKL 392 IGLLG NAT ENVDRV EALR ALQHCPK KL Sbjct: 362 IGLLGYNATTENVDRVAEALREALQHCPKNKL 393 >2CH1-A nrPDB Length = 396 Score = 495 bits (1274), Expect = e-140, Method: Composition-based stats. Identities = 167/379 (44%), Positives = 252/379 (66%) Query: 7 LVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQY 66 PP +L PL IP ++++GPGPSN R++ A ++ + ++++ MDE+K+G++Y Sbjct: 3 FTPPPASLRNPLIIPEKIMMGPGPSNCSKRVLTAMTNTVLSNFHAELFRTMDEVKDGLRY 62 Query: 67 VFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPM 126 +FQT N T+ +SGS H +EA L N+LE GD L+ NGIW +RAV++ ER GA V + Sbjct: 63 IFQTENRATMCVSGSAHAGMEAMLSNLLEEGDRVLIAVNGIWAERAVEMSERYGADVRTI 122 Query: 127 TKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVA 186 P ++L+ + + H+P LFLTHG+SS+G+LQPL+G G++CH++ CLL+VD+VA Sbjct: 123 EGPPDRPFSLETLARAIELHQPKCLFLTHGDSSSGLLQPLEGVGQICHQHDCLLIVDAVA 182 Query: 187 SLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKW 246 SL G P YMD+ ID +Y+G+QK L APPG + IS S KA + +R+TK FY D+ Sbjct: 183 SLCGVPFYMDKWEIDAVYTGAQKVLGAPPGITPISISPKALDVIRNRRTKSKVFYWDLLL 242 Query: 247 LANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALG 306 L N+WGC D+P+ YHHT+ +++LRE+LA IAE+GLEN ++ E A L+ L +G Sbjct: 243 LGNYWGCYDEPKRYHHTVASNLIFALREALAQIAEEGLENQIKRRIECAQILYEGLGKMG 302 Query: 307 LQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGC 366 L +FVKDP RLPTVT + +P G DW + Y +++F +E+ GGLGP+ GK R+G++G Sbjct: 303 LDIFVKDPRHRLPTVTGIMIPKGVDWWKVSQYAMNNFSLEVQGGLGPTFGKAWRVGIMGE 362 Query: 367 NATRENVDRVTEALRAALQ 385 +T + + + +L+ Sbjct: 363 CSTVQKIQFYLYGFKESLK 381 >2HUU-A nrPDB Length = 393 Score = 481 bits (1238), Expect = e-136, Method: Composition-based stats. Identities = 181/377 (48%), Positives = 247/377 (65%), Gaps = 1/377 (0%) Query: 8 VTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYV 67 VTPP L +PL PN+LL+GPGPSN P R++ A ++G + + +IMD+IKEG++Y+ Sbjct: 5 VTPPAVLREPLVTPNKLLMGPGPSNAPQRVLDAMSRPILGHLHPETLKIMDDIKEGVRYL 64 Query: 68 FQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMT 127 FQT N T +S SGH +EA L N+LE GD L+G G WG R+ D+ R GA V + Sbjct: 65 FQTNNIATFCLSASGHGGMEATLCNLLEDGDVILIGHTGHWGDRSADMATRYGADVRVVK 124 Query: 128 KDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVAS 187 G +L E+ + L HKP +LFLT G+SSTGVLQ L+G G LCH++ CLL+VD+VAS Sbjct: 125 SKVGQSLSLDEIRDALLIHKPSVLFLTQGDSSTGVLQGLEGVGALCHQHNCLLIVDTVAS 184 Query: 188 LGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWL 247 LGG P++MDR ID +Y+GSQK L APPG + +SFS +A ++ R TK +Y D+ + Sbjct: 185 LGGAPMFMDRWEIDAMYTGSQKVLGAPPGITPVSFSHRAVERYKRRNTKVKVYYWDMSLV 244 Query: 248 ANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGL 307 ++WGC +PR+YHHTI LY LRE++A+ E+GL +H + A L+ LQ G Sbjct: 245 GDYWGCFGRPRIYHHTISSTLLYGLREAIAMACEEGLPALIARHEDCAKRLYRGLQDAGF 304 Query: 308 QLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCN 367 +L+ DP RL TVTT+ VP G DW Y + + +EI GGLGP+ G+V RIGL+G N Sbjct: 305 ELYA-DPKDRLSTVTTIKVPQGVDWLKAAQYAMKTYLVEISGGLGPTAGQVFRIGLMGQN 363 Query: 368 ATRENVDRVTEALRAAL 384 AT E VDRV + + A+ Sbjct: 364 ATTERVDRVLQVFQEAV 380 >1VJO-A nrPDB Length = 393 Score = 467 bits (1201), Expect = e-132, Method: Composition-based stats. Identities = 164/371 (44%), Positives = 244/371 (65%), Gaps = 4/371 (1%) Query: 15 LKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPL 74 L+PL +P++LLLGPGPSN P ++ A + +G + +MDEI+ ++YV+QT NPL Sbjct: 27 LEPLEVPSRLLLGPGPSNAHPSVLQAMNVSPVGHLDPAFLALMDEIQSLLRYVWQTENPL 86 Query: 75 TLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHY 134 T+ +SG+G A+EA + N +EPGD L+G G +G R VD+ R GA V ++K G + Sbjct: 87 TIAVSGTGTAAMEATIANAVEPGDVVLIGVAGYFGNRLVDMAGRYGADVRTISKPWGEVF 146 Query: 135 TLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLY 194 +L+E+ L H+P +L L H E+STG QPL+G GELC + LLLVD+V SLGG P++ Sbjct: 147 SLEELRTALETHRPAILALVHAETSTGARQPLEGVGELCREFGTLLLVDTVTSLGGVPIF 206 Query: 195 MDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCD 254 +D G+D+ YS SQK L PG S + S +A +K+ R+TK ++YLD+ L +WG + Sbjct: 207 LDAWGVDLAYSCSQKGLGCSPGASPFTMSSRAIEKLQRRRTKVANWYLDMNLLGKYWGSE 266 Query: 255 DQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDP 314 R+YHHT P+ Y+LRE+L LIA++GL N W++H++ YL RL+ +GL L V + Sbjct: 267 ---RVYHHTAPINLYYALREALRLIAQEGLANCWQRHQKNVEYLWERLEDIGLSLHV-EK 322 Query: 315 ALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVD 374 RLPT+TTV +P G D + + +++ +IE+ GGLG GKV R+GL+G N+ +E+VD Sbjct: 323 EYRLPTLTTVCIPDGVDGKAVARRLLNEHNIEVGGGLGELAGKVWRVGLMGFNSRKESVD 382 Query: 375 RVTEALRAALQ 385 ++ AL L+ Sbjct: 383 QLIPALEQVLR 393 >3ISL-A nrPDB Length = 416 Score = 434 bits (1115), Expect = e-122, Method: Composition-based stats. Identities = 122/388 (31%), Positives = 198/388 (51%), Gaps = 22/388 (5%) Query: 15 LKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPL 74 + L P + ++ PGP + PR++ ++G IM+E E ++ +FQT+N Sbjct: 4 RRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTGIMNETMEMLRELFQTKNRW 63 Query: 75 TLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHY 134 I G+ +EA L +V+EP D L+ G +G +I ER GA VH + + G + Sbjct: 64 AYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLTEIAERYGANVHMLECEWGTVF 123 Query: 135 TLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLY 194 +++ + + KP ++ + HGE+STG + PL GE C L +VD+VA++GG + Sbjct: 124 DPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGEACRTEDALFIVDAVATIGGCEVK 183 Query: 195 MDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFS--------------- 239 +D ID G+QK L+ P G + I+++++ + +RK Sbjct: 184 VDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADVIAARKKVERGIATQADRAALSGNRP 243 Query: 240 ---FYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAA 296 Y D+ L ++W + R+ HHT LY+LRE + L+ E+GLE + +HR A Sbjct: 244 ITSNYFDLSQLEDYWS---ERRLNHHTEATTMLYALREGVRLVLEEGLETRFERHRHHEA 300 Query: 297 YLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTG 356 L ++A+GL+LF D + ++P VT V +P G D + ++ F IEI GP G Sbjct: 301 ALAAGIKAMGLRLF-GDDSCKMPVVTCVEIPGGIDGESVRDMLLAQFGIEIASSFGPLAG 359 Query: 357 KVLRIGLLGCNATRENVDRVTEALRAAL 384 K+ RIG +G + +ENV V L A L Sbjct: 360 KIWRIGTMGYSCRKENVLFVLAGLEAVL 387 >3NNK-A nrPDB Length = 411 Score = 426 bits (1096), Expect = e-120, Method: Composition-based stats. Identities = 131/387 (33%), Positives = 199/387 (51%), Gaps = 20/387 (5%) Query: 18 LSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLV 77 L+ P++LL+GPGP N PR++ A Q+IG M M+E+ + VF+T N T++ Sbjct: 9 LNPPSRLLMGPGPINADPRVLRAMSSQLIGQYDPAMTHYMNEVMALYRGVFRTENRWTML 68 Query: 78 ISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQ 137 + G+ +EA LV+ + PGD LV G +G +I R A VH + G +T Sbjct: 69 VDGTSRAGIEAILVSAIRPGDKVLVPVFGRFGHLLCEIARRCRAEVHTIEVPWGEVFTPD 128 Query: 138 EVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDR 197 +VE+ + + +P LL G++ST +LQPL GE+C RY L D+ ASLGG PL D Sbjct: 129 QVEDAVKRIRPRLLLTVQGDTSTTMLQPLAELGEICRRYDALFYTDATASLGGNPLETDV 188 Query: 198 QGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKP----------------FSFY 241 G+D + +G QK L P GTS I+ S + ++ + RK +S Y Sbjct: 189 WGLDAVSAGMQKCLGGPSGTSPITLSARMEEAIRRRKCVEEGIRTDAHRDGDEEMIYSNY 248 Query: 242 LDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGR 301 D+ + ++WG + R+ HHT +L+ RE LI ++GL+ +H+ L Sbjct: 249 FDLGMVMDYWGPE---RLNHHTEATTALFGARECARLILQEGLDYGIARHKLHGDALVKG 305 Query: 302 LQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRI 361 +QA+GL+ F D ++ V V +P G + +++ F IEI GP GKV RI Sbjct: 306 IQAMGLETF-GDLKHKMNNVLGVVIPQGINGDQARKLMLEDFGIEIGTSFGPLHGKVWRI 364 Query: 362 GLLGCNATRENVDRVTEALRAALQHCP 388 G +G NA ++ V AL A L + Sbjct: 365 GTMGYNARKDCVMTTLSALEAVLNYLK 391 >2DR1-A nrPDB Length = 386 Score = 364 bits (935), Expect = e-101, Method: Composition-based stats. Identities = 91/377 (24%), Positives = 177/377 (46%), Gaps = 10/377 (2%) Query: 17 PLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTL 76 + P L GP P ++ +QM SK+ ++ + E ++ + L Sbjct: 15 EMVKPKYKLFTAGPVACFPEVLEIMKVQMFSHRSKEYRKVHMDTVERLREFLEVEKGEVL 74 Query: 77 VISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTL 136 ++ SG +EA++ N + G LV G +G+R ++ E G + + +PG Sbjct: 75 LVPSSGTGIMEASIRNGVSKGGKVLVTIIGAFGKRYKEVVESNGRKAVVLEYEPGKAVKP 134 Query: 137 QEVEEGLAQHKPV-LLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYM 195 +++++ L ++ V + +T+ E+STGVL PL ++ + L+ VD+V+++GG + Sbjct: 135 EDLDDALRKNPDVEAVTITYNETSTGVLNPLPELAKVAKEHDKLVFVDAVSAMGGADIKF 194 Query: 196 DRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDD 255 D+ G+D+++S SQKA PPG ++ +FS++ + + K +Y DI + Sbjct: 195 DKWGLDVVFSSSQKAFGVPPGLAIGAFSERFLEI--AEKMPERGWYFDIPLYVKYL---K 249 Query: 256 QPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQ-HREAAAYLHGRLQALGLQLFVKDP 314 + T P+ ++ + +L +I + G + W + + + A + ++ +GL + +P Sbjct: 250 EKESTPSTPPMPQVFGINVALRIIEKMGGKEKWLEMYEKRAKMVREGVREIGLDILA-EP 308 Query: 315 ALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVD 374 PT+T V P G D V + E+ G G K RIG +G E++ Sbjct: 309 GHESPTITAVLTPPGIKG-DEVYEAMRKRGFELAKGYGSVKEKTFRIGHMGY-MKFEDIQ 366 Query: 375 RVTEALRAALQHCPKKK 391 + + LR + K+K Sbjct: 367 EMLDNLREVINELKKQK 383 >2Z9W-A nrPDB Length = 392 Score = 350 bits (898), Expect = 6e-97, Method: Composition-based stats. Identities = 89/368 (24%), Positives = 159/368 (43%), Gaps = 5/368 (1%) Query: 24 LLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGH 83 + L GP N P ++ G ++ + +++ + Q + N +++ G Sbjct: 11 ITLTAGPVNAYPEVLRGLGRTVLYDYDPAFQLLYEKVVDKAQKAMRLSNK-PVILHGEPV 69 Query: 84 CALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGL 143 LEAA +++ P D L A+G++G+ +R + + Q V + L Sbjct: 70 LGLEAAAASLISPDDVVLNLASGVYGKGFGYWAKRYSPHLLEIEVPYNEAIDPQAVADML 129 Query: 144 AQHKPV-LLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDI 202 H + ++ + H ++ +G + P+D G L + L+VD+V+S GG + + DI Sbjct: 130 KAHPEITVVSVCHHDTPSGTINPIDAIGALVSAHGAYLIVDAVSSFGGMKTHPEDCKADI 189 Query: 203 LYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHH 262 +G K L APPG +++ S++A KM + P + L I N W D + + Sbjct: 190 YVTGPNKCLGAPPGLTMMGVSERAWAKMKANPLAPRASMLSIVDWENAWSRD---KPFPF 246 Query: 263 TIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVT 322 T V + L +L L +G E W +H A + + A+GL ++ ++ PT T Sbjct: 247 TPSVSEINGLDVALDLYLNEGPEAVWARHALTAKAMRAGVTAMGLSVWAASDSIASPTTT 306 Query: 323 TVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRA 382 V P G D + + + + G G + GK+ RIG +G A AL Sbjct: 307 AVRTPDGVDEKALRQAARARYGVVFSSGRGETLGKLTRIGHMGPTAQPIYAIAALTALGG 366 Query: 383 ALQHCPKK 390 A+ +K Sbjct: 367 AMNAAGRK 374 >2YRI-A nrPDB Length = 353 Score = 349 bits (895), Expect = 1e-96, Method: Composition-based stats. Identities = 121/362 (33%), Positives = 185/362 (51%), Gaps = 14/362 (3%) Query: 24 LLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQT-RNPLTLVISGSG 82 LLL PGP+ +P R+ A M G + ++ ++ I+E + +F L ++GSG Sbjct: 2 LLLTPGPTPIPERVQKALLRPMRGHLDPEVLRVNRAIQERLAALFDPGEGALVAALAGSG 61 Query: 83 HCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEG 142 +EA L N+ LV NG + QR ++ G + PG + V Sbjct: 62 SLGMEAGLANL--DRGPVLVLVNGAFSQRVAEMAALHGLDPEVLDFPPGEPVDPEAVARA 119 Query: 143 LAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDI 202 L + + ++ L HGE+STGVL P + G L L +D+V +LG P M G+D Sbjct: 120 LKRRRYRMVALVHGETSTGVLNPAEAIGALAKEAGALFFLDAVTTLGMLPFSMRAMGVDY 179 Query: 203 LYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHH 262 ++GSQK L+APPG + I+ S +A+K + +YLD+ +A W + YHH Sbjct: 180 AFTGSQKCLSAPPGLAPIAASLEARKAFTGK----RGWYLDLARVAEHW----ERGGYHH 231 Query: 263 TIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVT 322 T PV+ Y+L E+L L+ E+G+ R+ RE A++ L+A G + + K A LPTV Sbjct: 232 TTPVLLHYALLEALDLVLEEGVAARERRAREVYAWVLEELKARGFRPYPK--ASPLPTVL 289 Query: 323 TVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRA 382 V P G D +V + + + GG+GP+ G+VLR+GL+G A RE +AL Sbjct: 290 VVRPPEGVDADRLVRALYAE-GVAVAGGIGPTRGQVLRLGLMGEGARREAYQAFLKALDR 348 Query: 383 AL 384 AL Sbjct: 349 AL 350 >3ZRR-A nrPDB Length = 384 Score = 325 bits (834), Expect = 2e-89, Method: Composition-based stats. Identities = 106/368 (28%), Positives = 189/368 (51%), Gaps = 8/368 (2%) Query: 22 NQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVF-QTRNPLTLVISG 80 ++LLL GP+ + ++ AG +G SK+ + + +G++YV ++N L+I G Sbjct: 2 DKLLLHVGPTTIKEDVLVAGLENNVGFTSKEFVEALAYSLKGLRYVMGASKNYQPLIIPG 61 Query: 81 SGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVE 140 G A+E+ + ++L+P D LV +NG++G R I +R V + PG + EVE Sbjct: 62 GGTSAMES-VTSLLKPNDKILVVSNGVFGDRWEQIFKRYPVNVKVLRPSPGDYVKPGEVE 120 Query: 141 EGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGI 200 E + + + L+ LTH E+STGV +P+ +Y L++VD V+S+G + + + Sbjct: 121 EEVRKSEYKLVALTHVETSTGVREPVKDVINKIRKYVELIVVDGVSSVGAEEVKAEEWNV 180 Query: 201 DILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIK-WLANFWGCDDQPRM 259 D+ + SQKAL + G L+ S KA + S+ + +YLD++ WL G ++ Sbjct: 181 DVYLTASQKALGSAAGLGLLLLSPKALSILDSQNSIA-GYYLDLRNWLPVMRGAEEGKAA 239 Query: 260 YHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLP 319 Y T PV + L E+ LI ++G+EN ++H A+ + L+ALGL++ + P Sbjct: 240 YFATPPVHVILQLAEAFRLIEKEGIENRIKRHTMVASAIRAGLEALGLEIVARRPESYSN 299 Query: 320 TVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEA 379 TVT V + D + +++ ++ +E G+ P+ K RIG +G + + Sbjct: 300 TVTGVILKVA-DPQKVLAGTVNE-GVEFAPGVHPAF-KYFRIGHMGWVTPNDAIIA-ISV 355 Query: 380 LRAALQHC 387 + L+ Sbjct: 356 IERTLRKL 363 >2BKW-A nrPDB Length = 385 Score = 319 bits (818), Expect = 1e-87, Method: Composition-based stats. Identities = 97/384 (25%), Positives = 162/384 (42%), Gaps = 21/384 (5%) Query: 24 LLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQT---RNPLTLVISG 80 LL PGP L + A + +G S + I + + + VF++ V++G Sbjct: 7 TLLIPGPIILSGAVQKALDVPSLGHTSPEFVSIFQRVLKNTRAVFKSAAASKSQPFVLAG 66 Query: 81 SGHCALEAALVNVL---EPGDSFLVGANGIWGQRAVDIGERIGARVHPMTK-DPGGHYTL 136 SG + N + P + LV + G + R D GA+V + G L Sbjct: 67 SGTLGWDIFASNFILSKAPNKNVLVVSTGTFSDRFADCLRSYGAQVDVVRPLKIGESVPL 126 Query: 137 QEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRY--KCLLLVDSVASLGGTPLY 194 + + E L+Q+ + +TH ++ST VL L + + + +VD+V S+G Sbjct: 127 ELITEKLSQNSYGAVTVTHVDTSTAVLSDLKAISQAIKQTSPETFFVVDAVCSIGCEEFE 186 Query: 195 MDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKM--YSRKTKPFSFYLDIK-WLANFW 251 D G+D + SQKA+ AP G S+ S + S+ ++ ++ W Sbjct: 187 FDEWGVDFALTASQKAIGAPAGLSISLCSSRFMDYALNDSKNGHVHGYFSSLRRWTPIME 246 Query: 252 GCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFV 311 + Y T PV + SL +L I E+GL W HRE + + L GLQL Sbjct: 247 NYEAGKGAYFATPPVQLINSLDVALKEILEEGLHKRWDLHREMSDWFKDSL-VNGLQL-- 303 Query: 312 KDPALRLPT-VTTVAVPAGY--DWRDIVSYVIDHFDIEIMGGLGPSTG-KVLRIGLLGCN 367 R P+ ++ + A Y D D+++++ H + I GG+ G K +RIG +G Sbjct: 304 -TSVSRYPSNMSAHGLTAVYVADPPDVIAFLKSH-GVVIAGGIHKDIGPKYIRIGHMGVT 361 Query: 368 ATRENVDRVTEALRAALQHCPKKK 391 A +N+ + +KK Sbjct: 362 ACNKNLPYMKNCFDLIKLALQRKK 385 >1M32-A nrPDB Length = 366 Score = 292 bits (748), Expect = 1e-79, Method: Composition-based stats. Identities = 92/371 (24%), Positives = 164/371 (44%), Gaps = 20/371 (5%) Query: 22 NQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQI--MDEIKEGIQYVFQTRNPLT-LVI 78 N LLL PGP + A D Y I +++I++ + + T +++ Sbjct: 4 NYLLLTPGPLTTSRTVKEAML--FDSCTWDDDYNIGVVEQIRQQLTALATASEGYTSVLL 61 Query: 79 SGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQE 138 GSG A+EA L + L P D L+ +NG +G R V++ +G H +Q Sbjct: 62 QGSGSYAVEAVLGSALGPQDKVLIVSNGAYGARMVEMAGLMGIAHHAYDCGEVARPDVQA 121 Query: 139 VEEGLAQHKPVL--LFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMD 196 + + + P + + + H E++TG+L P+D G L HRY +VD+++S GG P+ + Sbjct: 122 I-DAILNADPTISHIAMVHSETTTGMLNPIDEVGALAHRYGKTYIVDAMSSFGGIPMDIA 180 Query: 197 RQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGC-DD 255 ID L S + K + PG +F ++K+ + K S LD+ W C +D Sbjct: 181 ALHIDYLISSANKCIQGVPG---FAFVIAREQKLAACKGHSRSLSLDL---YAQWRCMED 234 Query: 256 QPRMYHHTIPVISLYSLRESLALIAEQ-GLENSWRQHREAAAYLHGRLQALGLQLFVKDP 314 + T P ++ + ++L +A++ G+ +++++ L ++ALG + D Sbjct: 235 NHGKWRFTSPTHTVLAFAQALKELAKEGGVAARHQRYQQNQRSLVAGMRALGFNTLL-DD 293 Query: 315 ALRLPTVTTVAVPAGYDWR-DIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENV 373 L P +T P +R + I G S RIG +G ++ Sbjct: 294 ELHSPIITAFYSPEDPQYRFSEFYRRLKEQGFVIYPGK-VSQSDCFRIGNIGE-VYAADI 351 Query: 374 DRVTEALRAAL 384 + A+R A+ Sbjct: 352 TALLTAIRTAM 362 >1IUG-A nrPDB Length = 352 Score = 276 bits (706), Expect = 1e-74, Method: Composition-based stats. Identities = 96/370 (25%), Positives = 152/370 (41%), Gaps = 32/370 (8%) Query: 25 LLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHC 84 LL PGP L P+ + A + ++ ++ + + ++ F+T L+++GSG Sbjct: 4 LLTPGPVRLHPKALEALARPQLHHRTEAAREVFLKARGLLREAFRTEGE-VLILTGSGTL 62 Query: 85 ALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLA 144 A+EA + N+ PG+ LV G + +R +I G V + G ++V A Sbjct: 63 AMEALVKNLFAPGERVLVPVYGKFSERFYEIALEAGLVVERLDYPYGDTPRPEDV----A 118 Query: 145 QHKPVLLFLTHGESSTGVLQPLDGFGELCHRY--KCLLLVDSVASLGGTPLYMDRQGIDI 202 + L L H E+STG L L + L+ D V SL + ++ G+D Sbjct: 119 KEGYAGLLLVHSETSTGALADLPALARAFKEKNPEGLVGADMVTSLLVGEVALEAMGVDA 178 Query: 203 LYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHH 262 SGSQK L PPG ++ S +A +++ KP +YLD+ Q Sbjct: 179 AASGSQKGLMCPPGLGFVALSPRALERL-----KPRGYYLDLA-----RELKAQKEGESA 228 Query: 263 TIPVISLY-----SLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALR 317 P I+L L E L + E +W+ A L+G + GL+ P Sbjct: 229 WTPAINLVLAVAAVLEEVLPRLEEHLALKAWQN-----ALLYGVGEEGGLR---PVPKRF 280 Query: 318 LPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVT 377 P V +P G + + + I GG GP GKV R+ L+G E + V Sbjct: 281 SPAVAAFYLPEGVPYARVKEAFAQRGAV-IAGGQGPLKGKVFRLSLMGAYDRYEAL-GVA 338 Query: 378 EALRAALQHC 387 R L+ Sbjct: 339 GMFREVLEEI 348 >3FFR-A nrPDB Length = 362 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 76/377 (20%), Positives = 147/377 (38%), Gaps = 33/377 (8%) Query: 22 NQLLLGPGPSNLPPRIMAAGGLQ------MIGSMSKDMYQIMDEIKEGIQYVFQTRNPLT 75 N++ PGPS L P + +I SK ++ + ++ + + + Sbjct: 4 NKIYFTPGPSELYPTVRQHMITALDEKIGVISHRSKKFEEVYKTASDNLKTLLELPSNYE 63 Query: 76 LVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPG-GHY 134 ++ S E + N +E V NG + +R + +G + G G Y Sbjct: 64 VLFLASATEIWERIIQNCVEKKSFHCV--NGSFSKRFYEFAGELGREAYKEEAAFGKGFY 121 Query: 135 TLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRY-KCLLLVDSVASLGGTPL 193 A+ ++ LTH E+S+GV P++ + L+ VD+V+SL P Sbjct: 122 PADITVPADAE----IICLTHNETSSGVSMPVEDINTFRDKNKDALIFVDAVSSL-PYP- 175 Query: 194 YMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYS--RKTKPFSFYLDIKWLANFW 251 D ID ++ QK P G + +D+ +K + K K Y I + Sbjct: 176 KFDWTKIDSVFFSVQKCFGLPAGLGVWILNDRVIEKSKALLAKRKSIGTYHTIPSMLEKA 235 Query: 252 GCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLF- 310 + P + + + L + + I+ G+ +Q E AA ++ +++ + F Sbjct: 236 RVNQTPET-PNAMNIFLLGKVTGDMLQISADGIR---KQTEEKAALINTYIESSKVFSFG 291 Query: 311 VKDPALRLPTV---TTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCN 367 V+D LR T T +P + +++ FD+ + G G +RI + Sbjct: 292 VEDAKLRSMTTIVANTTMLPGEIN------KILEPFDMAVGAGYGSKKETQIRIANFPAH 345 Query: 368 ATRENVDRVTEALRAAL 384 + E V ++ + L+ + Sbjct: 346 SL-EQVHKLVQTLKEKI 361 >3KE3-A nrPDB Length = 379 Score = 237 bits (604), Expect = 8e-63, Method: Composition-based stats. Identities = 85/367 (23%), Positives = 149/367 (40%), Gaps = 35/367 (9%) Query: 42 GLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFL 101 + + MSK ++M+++ ++ V+ ++I GSG +EA + L + L Sbjct: 22 TDRALNHMSKAFQEVMNDLLSNLKTVYNAE--AAVIIPGSGTYGMEA-VARQLTIDEDCL 78 Query: 102 VGANGIWGQRAVDIGER---------IGARVHPMTKDPGGHYTLQEVEEG---LAQHKPV 149 + NG + R I E+ + A T+ P + ++E + + K Sbjct: 79 IIRNGWFSYRWTQILEKGKFAKSSTVLTAERTEDTEAP-KPFAPVDIETAVAKIKEDKSA 137 Query: 150 LLFLTHGESSTGVL---QPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSG 206 +++ H E+S+G++ + + E H LL++D +AS G L M GID+L S Sbjct: 138 IVYAPHVETSSGIILSEEYIKALSEAVHSVGGLLVIDCIAS-GCVWLDMKELGIDVLISA 196 Query: 207 SQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIK-WLANFWGCDDQPRMYHHTIP 265 QK ++ P L+ S A KK+ S ++ FS LD+K WL ++ YH T+P Sbjct: 197 PQKGWSSTPCAGLVMLSAAAIKKVESTESNCFS--LDLKQWLTIMRAYENGGHAYHATMP 254 Query: 266 VISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVA 325 SL R+++ E G + E + L G++ + P V Sbjct: 255 TDSLRQFRDAILEAKEIGFDILRDAQWELGNRVRKVLTDKGIESVAAE-GFEAPGVVVSY 313 Query: 326 VPAGYDWRDIVSYVIDHFDIEIMGGL-----GPSTGKVLRIGLLGCNATRE---NVDRVT 377 ++I G+ P K R+GL G + + V+R Sbjct: 314 TERD---DMHKGSAFAEAGLQIAAGVPLKVGEPDNFKTFRLGLFGLDKLTDIDGTVERFE 370 Query: 378 EALRAAL 384 +AL L Sbjct: 371 KALDEVL 377 >3LVM-A nrPDB Length = 423 Score = 130 bits (328), Expect = 7e-31, Method: Composition-based stats. Identities = 42/235 (17%), Positives = 91/235 (38%), Gaps = 23/235 (9%) Query: 116 GERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHR 175 ER G V + G L+E+E + + +L+ + H + GV+Q + GE+C Sbjct: 133 LEREGFEVTYLAPQRNGIIDLKELEAAM-RDDTILVSIMHVNNEIGVVQDIAAIGEMCRA 191 Query: 176 YKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKT 235 + VD+ S+G P+ + + +D++ S S + P G + K + ++ ++ Sbjct: 192 RGIIYHVDATQSVGKLPIDLSQLKVDLM-SFSGHKIYGPKGIGALYVRRKPRVRIEAQ-- 248 Query: 236 KPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAA 295 G + M T+PV + + E+ + E+ + + R Sbjct: 249 --------------MHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEE-MATEMERLRGLR 293 Query: 296 AYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGG 350 L ++ + D P + V +++ + S ++ D+ + G Sbjct: 294 NRLWNGIKDIEEVYLNGDLEHGAPNILNV----SFNYVEGESLIMALKDLAVSSG 344 >3VOM-A nrPDB Length = 398 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 66/371 (17%), Positives = 127/371 (34%), Gaps = 32/371 (8%) Query: 26 LGPGPSNLPPRIMAAGGLQM-----IGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVI-S 79 G GPS + + + ++ ++ G+ +F + +++ + Sbjct: 44 FGSGPSKVRLEQLQTLTTTAAALFGTSHRQAPVKNLVGRVRSGLAELFSLPDGYEVILGN 103 Query: 80 GSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGA--RVHPMTKDPGGHYTLQ 137 G +AA +++ L G + + + +T DPG Q Sbjct: 104 GGATAFWDAAAFGLIDKRSLHL--TYGEFSAKFASAVSKNPFVGEPIIITSDPGSAPEPQ 161 Query: 138 EVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDR 197 + + ++ H E+STGV L+++D+ + GG P+ + Sbjct: 162 -TDPSVD-----VIAWAHNETSTGV---AVAVRRPEGSDDALVVIDATSGAGGLPVDIAE 212 Query: 198 QGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQP 257 D Y QK + G L S A ++ + + D L + Sbjct: 213 T--DAYYFAPQKNFASDGGLWLAIMSPAALSRIEAIAATGR-WVPDFLSLPIAVENSLKN 269 Query: 258 RMYHHTIPVISLYSLRESLA-LIAEQGLENSWRQHREAAAYLHGRLQALGLQL-FVKDPA 315 + Y +T + +L L E + L+ GL+ + ++ +++ L+ Q FV DP Sbjct: 270 QTY-NTPAIATLALLAEQIDWLVGNGGLDWAVKRTADSSQRLYSWAQERPYTTPFVTDPG 328 Query: 316 LRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGC------NAT 369 LR V T+ D + + + I LR+ + +A Sbjct: 329 LRSQVVGTIDFVDDVDAGTVAKILRAN-GIVDTEPYRKLGRNQLRVAMFPAVEPDDVSAL 387 Query: 370 RENVDRVTEAL 380 E VD V E L Sbjct: 388 TECVDWVVERL 398 >5WGB-A nrPDB Length = 426 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 50/305 (16%), Positives = 107/305 (35%), Gaps = 36/305 (11%) Query: 31 SNLPPRIMAAGGLQMIGSMSK----------DMYQIMDEIKEGIQYVFQTRNPLTLVISG 80 + L PR++ A +I + M+ ++ + + + SG Sbjct: 36 TPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPREIIFTSG 95 Query: 81 ---SGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDI--GERIGARVHPMTKDPGGHYT 135 S + A++ + L+ E G +V + G Sbjct: 96 ATESNNIAIK-GVARFYRSRKKHLITTQTEHKCVLDSCRSLEAEGFQVTYLPVQKSGIID 154 Query: 136 LQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYM 195 L+E+E + Q L+ + + GV QP+ G +C K D+ ++G PL + Sbjct: 155 LKELEAAI-QPDTSLVSVMTVNNEIGVKQPIAEIGRICSSRKVYFHTDAAQAVGKIPLDV 213 Query: 196 DRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDD 255 + ID++ S S + P G I + + ++ + ++ G Sbjct: 214 NDMKIDLM-SISGHKIYGPKGVGAIYIRRRPRVRVEALQS----------------GGGQ 256 Query: 256 QPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQ-HREAAAYLHGRLQALGLQLFVKDP 314 + M T+P + L + +A+Q +E ++ + + + +++L + DP Sbjct: 257 ERGMRSGTVPTPLVVGL-GAACEVAQQEMEYDHKRISKLSERLIQNIMKSLPDVVMNGDP 315 Query: 315 ALRLP 319 P Sbjct: 316 KHHYP 320 >1T3I-A nrPDB Length = 420 Score = 94.0 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 62/355 (17%), Positives = 130/355 (36%), Gaps = 21/355 (5%) Query: 47 GSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAAL----VNVLEPGDSFLV 102 +S + ++ + R+P +V + + A+ +N L+ GD + Sbjct: 64 HQLSVRATDAYEAVRNKVAKFINARSPREIVYTRNATEAINLVAYSWGMNNLKAGDEIIT 123 Query: 103 GANGIWGQR--AVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESST 160 + + GA + + D + L+ + L++ K L+ + H ++ Sbjct: 124 TVMEHHSNLVPWQMVAAKTGAVLKFVQLDEQESFDLEHFKTLLSE-KTKLVTVVHISNTL 182 Query: 161 GVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLI 220 G + P + +L H+ +LVD+ S PL + D L S + AP G + Sbjct: 183 GCVNPAEEIAQLAHQAGAKVLVDACQSAPHYPLDVQLIDCDWLV-ASGHKMCAPTGIGFL 241 Query: 221 SFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIA 280 ++ + M + + +F + + T + +L ++ + Sbjct: 242 YGKEEILEAMP--PFFGGGEMIAEVFFDHFTTGELPHKFEAGTPAIAEAIALGAAVDYLT 299 Query: 281 EQGLENSWRQHREAAAYLHGRLQAL-GLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYV 339 + G+EN E YL L + L+L+ +P AG D+ + + Sbjct: 300 DLGMENIHNYEVELTHYLWQGLGQIPQLRLYGPNPKHGDRAALASFNVAGLHASDVAT-M 358 Query: 340 IDHFDIEIMGGLGPS--TGKVL------RIGLLGCNATRENVDRVTEALRAALQH 386 +D I I G + ++ R L N T+E +D ++L+A ++ Sbjct: 359 VDQDGIAIRSGHHCTQPLHRLFDASGSARASLYFYN-TKEEIDLFLQSLQATIRF 412 >5WT2-A nrPDB Length = 401 Score = 93.2 bits (230), Expect = 1e-19, Method: Composition-based stats. Identities = 54/340 (15%), Positives = 118/340 (34%), Gaps = 47/340 (13%) Query: 31 SNLPPRIMAAGGL---------QMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGS 81 + + P++ + + + + E + + R+ ++I+ Sbjct: 13 TRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGINARDIDDVIITSC 72 Query: 82 GHCALEAALV-----NVLEPGDSFLVGANGIWG--QRAVDIGERIGARVHPMTKDPGGHY 134 + L L+ G + +V + + E +G V + + G Sbjct: 73 ATESNNWVLKGVYFDECLKKGKNHIVTTVAEHPAVRSTCNFLESLGVEVTYLPINEHGSI 132 Query: 135 TLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLY 194 T ++V E + + K L+ + + TG++ P++ G +C L D+V ++G P+ Sbjct: 133 TAEQVREAITE-KTALVSVMWANNETGLIFPIEEIGAICKEKGVLFHTDAVQAIGKIPVD 191 Query: 195 MDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCD 254 + + D L S S + P G + + F G + Sbjct: 192 VLKANADFL-SFSAHKFHGPKGIGGLYIRS------------------GVGLTPLFHGGE 232 Query: 255 DQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQL----F 310 T+ V + + E++ L E +E L +L+ L++ Sbjct: 233 HMNGRRSGTLNVPYIVGMGEAMKLAVEH-----LDYEKEVVGKLRDKLEEALLKIPDVMV 287 Query: 311 VKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGG 350 V D R+P T V+V G + ++ + ++ +I G Sbjct: 288 VGDRIHRVPNTTLVSV-RGIEGEAML-WDLNRSNIAASTG 325 >4W91-A nrPDB Length = 422 Score = 91.7 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 68/352 (19%), Positives = 128/352 (36%), Gaps = 22/352 (6%) Query: 46 IGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVN----VLEPGDSFL 101 + +S ++ +E ++ + +V + + A+ + GD L Sbjct: 74 LHFLSNAATDAYEKSRETVRRFLNAGSVDEIVFTKNATEAINTVAYGYGMPFIGEGDEIL 133 Query: 102 VGANGIWGQR--AVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESS 159 + I ER GA++ D G + ++E E+ L++ + L+ +TH ++ Sbjct: 134 LSIMEHHSNIVPWHFIRERQGAKLVFTPVDDNGVFHIEEFEKRLSE-RTKLVAITHMSNT 192 Query: 160 TGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSL 219 G + P+ EL H +LVD P+ + G D + + P G + Sbjct: 193 LGTVVPIKKIVELAHARGIPVLVDGSQGAVHLPVDVQDLGCDWYV-FTGHKVYGPSGIGV 251 Query: 220 ISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALI 279 + + +KM R + ++ N R T P++ L +L + Sbjct: 252 LYGRAQMLEKM--RPFQGGGEMIEEVTEENVTYNHPPHRFEAGTPPIVQAIGLGAALEYM 309 Query: 280 AEQGLENSWRQHREAAAYLHGRL-QALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSY 338 + G + Y H RL + L++F P + + A+ G D+ S Sbjct: 310 EKIGRHAILAHEADLRDYAHERLGRINSLRIFGNAPDKG--AIISFAL-EGIHAHDV-SM 365 Query: 339 VIDHFDIEIMGGLGPSTGKVLRIGL-------LGCNATRENVDRVTEALRAA 383 VID + + G + + R G+ TR VD + EAL A Sbjct: 366 VIDRAGVAVRAGTHCAQPLLKRFGVTSTCRASFALYNTRAEVDALAEALEKA 417 >6MRE-A nrPDB Length = 420 Score = 87.5 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 64/363 (17%), Positives = 119/363 (32%), Gaps = 32/363 (8%) Query: 40 AGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNV----LE 95 A + I ++S + M+ +++ R+ LV + + + Sbjct: 66 AAVHRGIHTLSAQATEKMENVRKRASLFINARSAEELVFVAGTTEGINLVANSWGNSNVR 125 Query: 96 PGDSFLVGANGIWGQR--AVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFL 153 GD+ ++ + R+GA + + +P G L+ + L K LL + Sbjct: 126 AGDNIIISQMEHHANIVPWQMLCARVGAELRVIPLNPDGTLQLETL-PTLFDEKTRLLAI 184 Query: 154 THGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNA 213 TH + G PL L H++ +LVD ++ P+ + D S L Sbjct: 185 THVSNVLGTENPLAEMITLAHQHGAKVLVDGAQAVMHHPVDVQALDCDFYV-FSGHKLYG 243 Query: 214 PPGTSLISFSDKAKKKMYSRKT-----KPFSFYLDIKWLANFWGCDDQPRMYHHTIPVIS 268 P G ++ + ++M + S W W + T Sbjct: 244 PTGIGILYVKEALLQEMPPWEGGGSMIATVSLSEGTTWTKAPWRFEAG------TPNTGG 297 Query: 269 LYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPA 328 + L +L ++ GL N ++ + + L + P RL + + Sbjct: 298 IIGLGAALEYVSALGLNN-IAEYEQNLMHYALSQLESVPDLTLYGPQNRLGVI-AFNL-- 353 Query: 329 GYDWRDIVSYVIDHFDIEIMGGLG---PSTGKV-----LRIGLLGCNATRENVDRVTEAL 380 G V +D++ I + G P R L N T E VDR+ L Sbjct: 354 GKHHAYDVGSFLDNYGIAVRTGHHCAMPLMAYYNVPAMCRASLAMYN-THEEVDRLVTGL 412 Query: 381 RAA 383 + Sbjct: 413 QRI 415 >6CZY-A nrPDB Length = 362 Score = 87.1 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 45/308 (14%), Positives = 109/308 (35%), Gaps = 34/308 (11%) Query: 26 LGPGPSNLPPRIM------------AAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNP 73 GP+ LP ++ + + + K+ I+ + + ++ + + Sbjct: 8 FAAGPATLPENVLLKAQADLYNWRGSGMSVMEMSHRGKEFLSIIQKAESDLRQLLEIPQE 67 Query: 74 LTLV-ISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGG 132 +++ + G A +N+ + D+ G WG +AV ++ + Sbjct: 68 YSVLFLQGGATTQFAALPLNLCKSDDTVDFVVTGSWGDKAVKEAKKYCKTNVIWSGKSEK 127 Query: 133 HYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTP 192 + + EE L + E+ GV F + L+ D ++ P Sbjct: 128 YTKVPSFEELEQTPDAKYLHICANETIHGV-----EFKDYPVPKNGFLVADMSSNFCSKP 182 Query: 193 LYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWG 252 + + + G+ +Y G+QK + P G +++ + DI + + Sbjct: 183 VDVSKFGV--IYGGAQKNVG-PSGVTIVII-----------RKDLIGNAQDITPVMLDYK 228 Query: 253 CDDQPRMYHHTIPVISLYSLRESL-ALIAEQGLENSWRQHREAAAYLHGRLQA-LGLQLF 310 D+ ++T P +Y L+ + GL+ ++++ A L+ ++ G Sbjct: 229 IHDENSSLYNTPPCFGIYMCGLVFEDLLEQGGLKEVEKKNQRKADLLYNAIEESNGFFRC 288 Query: 311 VKDPALRL 318 + ++R Sbjct: 289 PVEKSVRS 296 >5XT5-A nrPDB Length = 419 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 55/346 (15%), Positives = 121/346 (34%), Gaps = 27/346 (7%) Query: 57 MDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNV----LEPGDSFLVGANGIWGQR- 111 + +E ++ ++ ++ + +L ++ L+PGD ++ Sbjct: 70 YEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALSYARANLKPGDEVVITYMEHHANII 129 Query: 112 -AVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFG 170 + GA + + G +L++V E + + ++ ++H + G + P+ Sbjct: 130 PWQQAVKATGATLKYIPLQEDGTISLEDVRETVTSN-TKIVAVSHVSNVLGTVNPIKEMA 188 Query: 171 ELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKM 230 ++ H +++VD S + + D S K + P G ++ + M Sbjct: 189 KIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFFALSSHK-MCGPTGVGVLYGKKALLENM 247 Query: 231 YSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQ 290 + +D L + + T + L ++ + E GL+ + Sbjct: 248 E--PAEFGGEMIDFVGLYESTWKELPWKFEAGTPIIAGAIGLGAAIDFLEEIGLDE-ISR 304 Query: 291 HREA-AAYLHGRLQAL-GLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIM 348 H AAY R + L G+ ++ + L T D+ + V+D I + Sbjct: 305 HEHKLAAYALERFRQLDGVTVYGPEERAGLVTFNL----DDVHPHDVAT-VLDAEGIAVR 359 Query: 349 GGLG---PSTG-----KVLRIGLLGCNATRENVDRVTEALRAALQH 386 G P R N T E +D++ EAL+ ++ Sbjct: 360 AGHHCAQPLMKWLDVTATARASFYLYN-TEEEIDKLVEALQKTKEY 404 >2BIG-A nrPDB Length = 361 Score = 82.8 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 53/340 (15%), Positives = 122/340 (35%), Gaps = 36/340 (10%) Query: 26 LGPGPSNLPPRIMA------------AGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNP 73 GPS LP + + + S+ ++ ++ + ++ + Q N Sbjct: 8 FNAGPSALPKPALERAQKELLNFNDTQMSVMELSHRSQSYEEVHEQAQNLLRELLQIPND 67 Query: 74 LTLV-ISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGG 132 ++ + G +N+L G G W ++A+ + +G + Sbjct: 68 YQILFLQGGASLQFTMLPMNLLTKGTIGNYVLTGSWSEKALKEAKLLGETHIAASTKANS 127 Query: 133 HYTLQEVEEGLAQHKPVLLFLTHGESSTGV-LQPLDGFGELCHRYKCLLLVDSVASLGGT 191 + ++ + E L +T + G Q L+ D + + Sbjct: 128 YQSIPDFSEFQLNENDAYLHITSNNTIYGTQYQNFPEINH------APLIADMSSDILSR 181 Query: 192 PLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFW 251 PL +++ G+ +Y+G+QK L P G +++ KK + + K + + + + Sbjct: 182 PLKVNQFGM--IYAGAQKNLG-PSGVTVVIV----KKDLLNTKVEQ------VPTMLQYA 228 Query: 252 GCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSW-RQHREAAAYLHGRL-QALGLQL 309 +Y +T P S+Y LR L I + G + +Q+ E A ++ + ++ G + Sbjct: 229 THIKSDSLY-NTPPTFSIYMLRNVLDWIKDLGGAEAIAKQNEEKAKIIYDTIDESNGFYV 287 Query: 310 FVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMG 349 + R T + + ++ + + + G Sbjct: 288 GHAEKGSRSLMNVTFNLRNEELNQQFLAKAKEQGFVGLNG 327 >1ECX-A nrPDB Length = 384 Score = 80.1 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 49/289 (16%), Positives = 96/289 (33%), Gaps = 46/289 (15%) Query: 120 GARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRY--K 177 G +V + D G L+E+E L L+ + + G +QP++ + + + Sbjct: 113 GFKVKYVPVDSRGVVKLEELE-KLVDEDTFLVSIMAANNEVGTIQPVEDVTRIVKKKNKE 171 Query: 178 CLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKP 237 L+ VD+V ++G P +++ +D S S + P G + RK P Sbjct: 172 TLVHVDAVQTIGKIPFSLEKLEVDYA-SFSAHKFHGPKGVGITYI----------RKGVP 220 Query: 238 FSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAY 297 G + + T V + ++ + E+ E + + + + Sbjct: 221 IR--------PLIHGGGQERGLRSGTQNVPGIVGAARAMEIAVEELSEAA-KHMEKLRSK 271 Query: 298 LHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPS--- 354 L L LG + + LP +V+ P + ++ + I + + Sbjct: 272 LVSGLMNLGAHIITP-LEISLPNTLSVSFPNI--RGSTLQNLLSGYGIYVSTSSACTSKD 328 Query: 355 ----------------TGKVLRIGLLGCNATRENVDRVTEALRAALQHC 387 +RI L N T E VD + + L Sbjct: 329 ERLRHVLDAMGVDRRIAQGAIRISLCKYN-TEEEVDYFLKKIEEILSFL 376 >2C0R-A nrPDB Length = 362 Score = 76.3 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 56/339 (16%), Positives = 117/339 (34%), Gaps = 34/339 (10%) Query: 26 LGPGPSNLPPRIMA------------AGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNP 73 GP+ LP ++ + + + +E + + + Sbjct: 8 FNAGPAALPLEVLERAQAEFVDYQHTGMSIMEMSHRGAVYEAVHNEAQARLLALLGNPTG 67 Query: 74 LTLV-ISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGG 132 ++ I G +N L+ G + G W +A+ + IG + + Sbjct: 68 YKVLFIQGGASTQFAMIPMNFLKEGQTANYVMTGSWASKALKEAKLIGDTHVAASSEASN 127 Query: 133 HYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTP 192 + TL +++E Q L LT E+ G F L+ D + + P Sbjct: 128 YMTLPKLQEIQLQDNAAYLHLTSNETIEG-----AQFKAFPDTGSVPLIGDMSSDILSRP 182 Query: 193 LYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWG 252 +++ G+ +Y+G+QK L P G +++ + + + + + Sbjct: 183 FDLNQFGL--VYAGAQKNLG-PSGVTVVIVRE---DLVAESPKH-------LPTMLRYDT 229 Query: 253 CDDQPRMYHHTIPVISLYSLRESLALIAE-QGLENSWRQHREAAAYLHGRL-QALGLQLF 310 +Y +T P +Y + E L I E GLE + +R+ A+ ++ + Q+ G Sbjct: 230 YVKNNSLY-NTPPSFGIYMVNEVLKWIEERGGLEGVQQANRKKASLIYDAIDQSGGFYRG 288 Query: 311 VKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMG 349 D R T + + ++ V + + G Sbjct: 289 CVDVDSRSDMNITFRLASEELEKEFVKASEQEGFVGLKG 327 >3QBO-A nrPDB Length = 364 Score = 75.5 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 49/297 (16%), Positives = 109/297 (36%), Gaps = 34/297 (11%) Query: 26 LGPGPSNLPPRIMA------------AGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNP 73 GP+ LP ++ + + SK+ Q+ +E ++ ++ + Sbjct: 10 FSAGPAMLPVEVLRRAQQELRDWHGLGTSVMEVSHRSKEFMQVAEESEKDLRDLLNVPAN 69 Query: 74 LTLVI-SGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERI-GARVHPMTKDPG 131 ++ G A +N+L +S G W A+ ++ V +T Sbjct: 70 YKVLFCHGGARAQFAAVPLNLLGDRNSADYVDGGYWAHSAIKEAQKYCTPNVIDVTTHDN 129 Query: 132 GHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGT 191 G +Q +++ + E+ G+ E +++ D +S+ Sbjct: 130 GLTGIQPMKQWKLSDNAAYVHYCPNETIDGI-----AIDEQPDFGNKVVVADFSSSILSR 184 Query: 192 PLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFW 251 P+ + R G+ +Y+G+QK + P G +L+ + K ++ + + ++ Sbjct: 185 PIDVSRYGV--IYAGAQKNIG-PAGLTLVIVREDLLGKAHTA----------LPSILDYK 231 Query: 252 GCDDQPRMYHHTIPVISLYSLRESLALIAEQ-GLENSWRQHREAAAYLHGRLQALGL 307 D M+ +T P + Y + EQ GL ++++ A L+G + G Sbjct: 232 ILADNDSMF-NTPPTFAWYLSGLVFKWLKEQGGLGEMEKRNQAKAELLYGAIDRTGF 287 >4EB7-A nrPDB Length = 382 Score = 73.6 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 67/390 (17%), Positives = 126/390 (32%), Gaps = 59/390 (15%) Query: 32 NLPPRIMAAGGLQM---------IGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSG 82 + RI+ A M + S + + E +E + + + SG+ Sbjct: 11 PVDERILEAMLPYMTESFGNPSSVHSYGFKAREAVQEAREKVAKLVNGGGGTVVFTSGAT 70 Query: 83 HCALEAALVNVLE---PGDSFLVGANGIWGQ-RAVDIGERIGARVHPMTKDPGGHYTLQE 138 A + + G LV A ++ G V + G + Sbjct: 71 EANNLAIIGYAMRNARKGKHILVSAVEHMSVINPAKFLQKQGFEVEYIPVGKYGEVDVSF 130 Query: 139 VEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQ 198 +++ L + +L+ + H + G +QP++ E+ K L +D+ AS+G + +++ Sbjct: 131 IDQKL-RDDTILVSVQHANNEIGTIQPVEEISEVL-AGKAALHIDATASVGQIEVDVEKI 188 Query: 199 GIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPR 258 G D+L S + P G + +AK G + Sbjct: 189 GADMLTISSND-IYGPKGVGALWIRKEAK------------------LQPVILGGGQENG 229 Query: 259 MYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQL----FVKDP 314 + + V S+ ++ + A + WR+ E L R+ L++ P Sbjct: 230 LRSGSENVPSIVGFGKAAEITAME-----WREEAERLRRLRDRIIDNVLKIEESYLNGHP 284 Query: 315 ALRLPTVTTVAVP-------------AGYD---WRDIVSYVIDHFDIEIMGGLGPSTGKV 358 RLP V AG S + + + GL Sbjct: 285 EKRLPNNVNVRFSYIEGESIVLSLDMAGIQASTGSACSSKTLQPSHVLMACGLKHEEAHG 344 Query: 359 LRIGLLGCNATRENVDRVTEALRAALQHCP 388 + LG T E+VDR+ E L ++ Sbjct: 345 TLLLTLGRYNTDEDVDRLLEVLPGVIERLR 374 >5F8V-A nrPDB Length = 379 Score = 73.2 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 61/382 (15%), Positives = 120/382 (31%), Gaps = 40/382 (10%) Query: 26 LGPGPSNLPPRIMA------------AGGLQMIGSMSKDMYQIMDEIKEGIQYVFQ-TRN 72 GP+ +P + + + K + E E ++ + Q N Sbjct: 9 FSAGPAAVPLECLERAAAEMTNWRNSGMSVIEVSHRGKHWMEEQKEATERLRTLLQVPEN 68 Query: 73 PLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERI---GARVHPMTK- 128 L ++G A N + + G W ++A D +R+ G V+ + Sbjct: 69 FNILFVAGGASLQFSAIPFNFIGEHKAVDYLCTGTWSKKAFDECKRLAFPGVTVNSVAGN 128 Query: 129 DPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGV-LQPLDGFGELCHRYKCLLLVDSVAS 187 P + + + E+ G+ Q L++D ++ Sbjct: 129 PPANPVEVPARDTWKLSEDAAYFYYCDNETIQGIEFQQFPDVPAP-------LIIDMSSN 181 Query: 188 LGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWL 247 P+ + + +++ +QK G S++ +K M R KPF Sbjct: 182 FLSRPI-TQWEKVGCIFACAQKNFGL-AGMSVVII----RKDMLERPVKPF-----CPIT 230 Query: 248 ANFWGCDDQPRMYHHTIPVISLYSLRESLALIAE-QGLENSWRQHREAAAYLHGRLQALG 306 ++ MY +T P ++Y I E GL ++E A ++ + + Sbjct: 231 MDYRIQVKNNCMY-NTPPTFAIYFANHIFKWIEEKGGLAAMDALNKEKAKKVYEAIDSNP 289 Query: 307 LQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGC 366 + P R P GY+ +D+ + L G V +G Sbjct: 290 NFVNRIKPEWRSRMNMPFFRPDGYENKDL-DADAKFVNFCTQRKLLTLKGHV-SVGGFRA 347 Query: 367 NATRENVDRVTEALRAALQHCP 388 + +AL A++ P Sbjct: 348 SCYNACPMEAVDALVQAMKEWP 369 >3M5U-A nrPDB Length = 361 Score = 72.4 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 44/310 (14%), Positives = 100/310 (32%), Gaps = 35/310 (11%) Query: 23 QLLLGPGPSNLPPRIMAAGGLQM------------IGSMSKDMYQIMDEIKEGIQYVFQT 70 ++ GPS LP I+ ++ I +K ++ +E + +++ Sbjct: 6 KINFSAGPSTLPLEILEQAQKELCDYQGRGYSIMEISHRTKVFEEVHFGAQEKAKKLYEL 65 Query: 71 RNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDP 130 + ++ G A + L G+W ++A+ + +G V + Sbjct: 66 NDDYEVLFLQGGASLQFAMIPMNLALNGVCEYANTGVWTKKAIKEAQILGVNVKTVASSE 125 Query: 131 GGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGG 190 ++ E ++ + G + + K L+VD+ + Sbjct: 126 ESNFDHIPRVEFSDNADYA--YICSNNTIYGTQY------QNYPKTKTPLIVDASSDFFS 177 Query: 191 TPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANF 250 + I + Y G QK G S I ++ +++ YL Sbjct: 178 RKVDFS--NIALFYGGVQKNAGI-SGLSCIFIRKDMLERSKNKQIPSMLNYLT------- 227 Query: 251 WGCDDQPRMYHHTIPVISLYSLRESLA-LIAEQGLENSWRQHREAAAYLHGRLQ-ALGLQ 308 + + +T P ++Y + L+ + GL+ ++ + A L+ + + G Sbjct: 228 ---HAENQSLFNTPPTFAIYMFNLEMDWLLNQGGLDKVHEKNSQKATMLYECIDLSNGFY 284 Query: 309 LFVKDPALRL 318 D R Sbjct: 285 KGHADKKDRS 294 >4Q75-A nrPDB Length = 429 Score = 71.7 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 45/316 (14%), Positives = 109/316 (34%), Gaps = 14/316 (4%) Query: 46 IGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNV----LEPGDSFL 101 I +S + ++ + + +V + + A+ + L+PGD + Sbjct: 73 IHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPGDEVI 132 Query: 102 VGANGIWG--QRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESS 159 + + ++ GA + +T + + ++ E L K L+ + H + Sbjct: 133 LTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRE-LISPKTKLVAVHHVSNV 191 Query: 160 TGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSL 219 P++ H +LVD+ S+ + + + D L + S K + P G Sbjct: 192 LASSLPIEEIVVWAHDVGAKVLVDACQSVPHMVVDVQKLNADFLVASSHK-MCGPTGIGF 250 Query: 220 ISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALI 279 + M + +L + + R T + +L ++ + Sbjct: 251 LYGKSDLLHSMP--PFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAIALGAAVDYL 308 Query: 280 AEQGLENSWRQHREAAAYLHGRLQAL-GLQLFVKDP--ALRLPTVTTVAVPAGYDWRDIV 336 + G+ E YL+ +L +L ++++ P ++ + + V G D+ Sbjct: 309 SGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNV-EGLHPTDLA 367 Query: 337 SYVIDHFDIEIMGGLG 352 +++ + I G Sbjct: 368 TFLDQQHGVAIRSGHH 383 >5YD2-A nrPDB Length = 354 Score = 71.3 bits (173), Expect = 8e-13, Method: Composition-based stats. Identities = 53/317 (16%), Positives = 111/317 (35%), Gaps = 33/317 (10%) Query: 39 AAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSG-HCALEAALVNVLEPG 97 + I SK+ +M+E K ++ V ++ G G +N+L Sbjct: 29 EGLSILEISHRSKEWINVMNETKALMKEVMDIPEGYEILFFGGGASLQFLMVAMNLL--N 86 Query: 98 DSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGE 157 G+W +A+ E IG V + +YT + E +T Sbjct: 87 KKACYLDTGVWASKAIKEAENIG-EVKIIGTSKDKNYT--YIPEYQIPSDYDYFHITTNN 143 Query: 158 S--STGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPP 215 + T + + ++ L+ D + + P+ + + + +Y+G+QK A Sbjct: 144 TIYGTEIRKDIES--------PIPLVADMSSDILSKPIDISKYSL--IYAGAQKNCGA-A 192 Query: 216 GTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRES 275 G +++ + K+ + I + ++ MY +T PVIS++++ ++ Sbjct: 193 GVTIVIIKKEILGKVQRK----------IPIILDYQVHILNNSMY-NTPPVISIFTVNQT 241 Query: 276 LALIAEQGLENSWRQ-HREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYD--W 332 L I + G ++ + E A L+ + + R + Y Sbjct: 242 LKYIKKIGGLKKIQELNEEKARLLYAEIDRNKIFRGTVRKKDRSIMNVCFVMEEQYKQLE 301 Query: 333 RDIVSYVIDHFDIEIMG 349 + Y + I I G Sbjct: 302 NEFSEYALQKGIIGIKG 318 >5HH9-A nrPDB Length = 390 Score = 70.1 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 69/323 (21%), Positives = 117/323 (36%), Gaps = 34/323 (10%) Query: 76 LVISGSGHCALEAALVNVL-EPGDSFLVGANGIWGQ--RAVDIGERIGARVHP--MTKDP 130 + ++GS L A +L +PG L ++ + +R+G +V + KDP Sbjct: 79 VALTGSTTDGLAAIYGGLLVQPGKEILTSSHEHYSTYTTLEYRHKRMGTQVREFPLFKDP 138 Query: 131 GGHYTLQEVEEGLAQHKP--VLLFLTHGESSTGVLQPLDGFGELCHRYK--------CLL 180 + + AQ +P +L +T +S +GV P+ G+L + Sbjct: 139 HRVSADEILSSIAAQIRPQTRVLGMTWVQSGSGVKLPIREIGKLVRELNQKRDEQDRIIY 198 Query: 181 LVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKK--MYSRKTKPF 238 +VD V G + D +G+ K L P GT +I + ++ + S T Sbjct: 199 VVDGVHGFGVEDVSFADFDCDYFIAGTHKWLFGPRGTGVIIARSEQLQEHLVPSIPTFSR 258 Query: 239 SFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYL 298 A+ +G P YH +L + L + G + + AYL Sbjct: 259 ---------ADNFGTLMTPGGYHAFE---HRLALGTAFELHLQLGKAEVQARIHQLNAYL 306 Query: 299 HGRLQAL-GLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGK 357 RL ++L T V G D + +++ H I + G Sbjct: 307 KQRLGEHPKVRLVTPTSPELSSGFTFFRV-EGRDCEAVAKHLMAHR--VISDAVDRDVGP 363 Query: 358 VLRIGLLGCNATRENVDRVTEAL 380 V+R+ N E +DRV E L Sbjct: 364 VVRLAPSLLNDEAE-IDRVLEIL 385 >4XK1-A nrPDB Length = 369 Score = 69.4 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 48/308 (15%), Positives = 101/308 (32%), Gaps = 35/308 (11%) Query: 26 LGPGPSNLPPRIM------------AAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNP 73 GP+ LP ++ + + S D I + ++ ++ + + Sbjct: 16 FCAGPAALPDAVLQRAQAELLDWRGKGLSVMEMSHRSDDYVAIASKAEQDLRDLLDIPSD 75 Query: 74 LTLV-ISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGG 132 ++ + G +N+L GIW ++A++ R G + Sbjct: 76 YKVLFLQGGASQQFAEIPLNLLPEDGVADYIDTGIWSKKAIEEARRYGTVNVAASAKEYD 135 Query: 133 HYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQP-LDGFGELCHRYKCLLLVDSVASLGGT 191 ++ + E + E+ G+ + G L+ D + + Sbjct: 136 YFAIPGQNEWTLTKDAAYVHYASNETIGGLEFDWIPETG------DVPLVTDMSSDILSR 189 Query: 192 PLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFW 251 PL + R G+ +Y+G+QK + P G ++ + + S + N+ Sbjct: 190 PLDVSRFGL--IYAGAQKNIG-PSGLVVVIVREDLLGRARSV----------CPTMLNYK 236 Query: 252 GCDDQPRMYHHTIPVISLYSLRESLALIAEQ-GLENSWRQHREAAAYLHGRLQALGLQLF 310 D MY +T S Y + EQ G+ +++R L+ + A Sbjct: 237 TAADNGSMY-NTPATYSWYLSGLVFEWLKEQGGVTAMEQRNRAKKDLLYKTIDASDFYTN 295 Query: 311 VKDPALRL 318 P+ R Sbjct: 296 PIQPSARS 303 >1QZ9-A nrPDB Length = 416 Score = 69.4 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 64/402 (15%), Positives = 130/402 (32%), Gaps = 46/402 (11%) Query: 12 KALLKPLSIPNQLL------LGPGPSNLPPRIMAAGGLQ-----MIGSMSKDMYQIMDEI 60 L + ++P ++ LG P R A + + S + + + Sbjct: 17 APLRQQFALPEGVIYLDGNSLGARPVAALARAQAVIAEEWGNGLIRSWNSAGWRDLSERL 76 Query: 61 KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVL------EPGDSFLVGANGIW------ 108 + + R+ +V++ + L L L P +V + Sbjct: 77 GNRLATLIGARDG-EVVVTDTTSINLFKVLSAALRVQATRSPERRVIVTETSNFPTDLYI 135 Query: 109 GQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDG 168 + D+ ++ G + + + +E+ + + Q ++ LTH TG + + Sbjct: 136 AEGLADMLQQ-GYTLRLVD-------SPEELPQAIDQD-TAVVMLTHVNYKTGYMHDMQA 186 Query: 169 FGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGT-SLISFSDKAK 227 L H L + D S G P+ + + G D + K LN PG+ + + S + Sbjct: 187 LTALSHECGALAIWDLAHSAGAVPVDLHQAGADYAIGCTYKYLNGGPGSQAFVWVSPQLC 246 Query: 228 KKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENS 287 + + F + + R T P+ SL + L + A+ + + Sbjct: 247 DLVPQPLSGWFGHSRQFAMEPRYEPSNGIARYLCGTQPITSLAMVECGLDVFAQTDMASL 306 Query: 288 WRQHREAAAYLHGRLQ----ALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHF 343 R+ ++ A L L + + + P GY ++ +ID Sbjct: 307 RRKSLALTDLFIELVEQRCAAHELTLVTPREHAKRGSHVSFEHPEGY---AVIQALIDRG 363 Query: 344 DIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRAALQ 385 I P +++R G T V + L L Sbjct: 364 --VIGDYREP---RIMRFGFTPLYTTFTEVWDAVQILGEILD 400 >1BJO-A nrPDB Length = 360 Score = 65.9 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 54/360 (15%), Positives = 115/360 (31%), Gaps = 68/360 (18%) Query: 26 LGPGPSNLPPRIMA------------AGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNP 73 GP+ LP ++ + + K+ Q+ +E ++ + + + Sbjct: 5 FSSGPAMLPAEVLKQAQQELRDWNGLGTSVMEVSHRGKEFIQVAEEAEKDFRDLLNVPSN 64 Query: 74 LTLVI-SGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGG 132 ++ G G A +N+L + G W A+ ++ P Sbjct: 65 YKVLFCHGGGRGQFAAVPLNILGDKTTADYVDAGYWAASAIKEAKKY--------CTPN- 115 Query: 133 HYTLQEVEEGLAQHKPVL-------LFLTH---GESSTGV-LQPLDGFGELCHRYKCLLL 181 + + +GL KP+ H E+ G+ + FG ++ Sbjct: 116 VFDAKVTVDGLRAVKPMREWQLSDNAAYMHYCPNETIDGIAIDETPDFGA-----DVVVA 170 Query: 182 VDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFY 241 D +++ P+ + R G+ +Y+G+QK + P G +++ ++ + + Sbjct: 171 ADFSSTILSRPIDVSRYGV--IYAGAQKNIG-PAGLTIVIV----REDLLGKANIACPSI 223 Query: 242 LDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLA-LIAEQGLENSWRQHREAAAYLHG 300 LD L + +T P + Y L A G+ + +++ A L+G Sbjct: 224 LDYSIL-------NDNGSMFNTPPTFAWYLSGLVFKWLKANGGVAEMDKINQQKAELLYG 276 Query: 301 RLQALGL--QLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIE--IMGGLGPSTG 356 + K R+ + +D +E GL G Sbjct: 277 VIDNSDFYRNDVAKRNRSRMNV-----------PFQLADSALDKLFLEESFAAGLHALKG 325 >4ISY-A nrPDB Length = 404 Score = 64.3 bits (155), Expect = 9e-11, Method: Composition-based stats. Identities = 44/245 (17%), Positives = 82/245 (33%), Gaps = 25/245 (10%) Query: 115 IGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPV-LLFLTHGESSTGVLQPLDGFGELC 173 + E GA V + G + + E L H V L+ + + G + P+ + Sbjct: 121 LVEHEGAHVTWLPTAADGSVSATALREALQSHDDVALVSVMWANNEVGTILPIAEMSVVA 180 Query: 174 HRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSR 233 + + D++ ++G PL G+ + S + PPG + Sbjct: 181 MEFGVPMHSDAIQAVGQLPLDFGASGLSAM-SVAGHKFGGPPGVGALLLRR--------- 230 Query: 234 KTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHRE 293 D+ + G + + T V S + + A IA GLE + + R Sbjct: 231 ---------DVTCVPLMHGGGQERDIRSGTPDVASAVGMATA-AQIAVDGLEENSARLRL 280 Query: 294 AAAYLHGRL--QALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGL 351 L + + + L D +RL G + ++ ++D IE G Sbjct: 281 LRDRLVEGVLAEIDDVCLNGADDPMRL-AGNAHFTFRGCEGDALL-MLLDANGIECSTGS 338 Query: 352 GPSTG 356 + G Sbjct: 339 ACTAG 343 >4MY5-A nrPDB Length = 393 Score = 64.0 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 63/388 (16%), Positives = 126/388 (32%), Gaps = 49/388 (12%) Query: 20 IPNQLLLGPG------PSNLPPRIMAAGGLQMIGSMSKDMYQIMDE-----IKEGIQYVF 68 IP+ L L G P ++ A + + +KE + Sbjct: 31 IPDVLKLTLGEPDFATPKHIKEAAKRAIDADESHYTGMAGLLALRQAASAFVKEKYHLTY 90 Query: 69 QTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTK 128 N ++++ AL A+L +LEPGD L+ A G + +GA V + Sbjct: 91 NPDN--EILVTIGATEALSASLTAILEPGDKVLLPAPAYPG--YEPVVNLVGAEVVEIDT 146 Query: 129 DPGGHY-TLQEVEEGLAQHKPVL--LFLTHGESSTGV---LQPLDGFGELCHRYKCLLLV 182 T + +EE + + L + L + + TGV Q + E+ +Y ++ Sbjct: 147 RSNDFVLTPEMLEEAILKEGEALKAVILNYPTNPTGVTYSRQQIKNLAEVLKKYPIFVIS 206 Query: 183 DSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYL 242 D V + ++ Y+G + S+ + L Sbjct: 207 DEVYA-------------ELTYTGESHV-----SIAEYLPDQTILISGLSKSHAMTGWRL 248 Query: 243 DIKWLANFWGCDDQP-RMYHHTIPVISL-YSLRESLALIAEQGLENSWRQHREAAAYLHG 300 + + Y T S+ ++ E+L + L ++ + Y+ Sbjct: 249 GLIFAPAVLTAQLIKSHQYLVTAATTSVQFAAIEALTNGKDDALPMK-EEYIKRRDYIIE 307 Query: 301 RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGG--LGPSTGKV 358 +++A+ ++ D A + V G D + + + G G Sbjct: 308 KMEAMKFKIIKPDGAFY--IFAKIPVAQGQDSFKFLQDFAKEKAVAFIPGVAFGKYGEGY 365 Query: 359 LRIGLLGCNATRENVDRVTEALRAALQH 386 LRI A+ E + + L+ ++ Sbjct: 366 LRIS---YAASMETIKEAMKRLKEFMEQ 390 >3QM2-A nrPDB Length = 386 Score = 62.0 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 52/351 (14%), Positives = 116/351 (33%), Gaps = 50/351 (14%) Query: 26 LGPGPSNLPPRIMA------------AGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNP 73 GP+ LP ++ + I K+ Q+ +E ++ + + + Sbjct: 31 FSSGPAMLPAEVLKLAQQELCDWHGLGTSVMEISHRGKEFIQVAEEAEQDFRDLLNIPSN 90 Query: 74 LTLVI-SGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERI-GARVHPMTKDPG 131 ++ G G +N+L + G W A+ ++ ++ Sbjct: 91 YKVLFCHGGGRGQFAGVPLNLLGDKTTADYVDAGYWAASAIKEAKKYCAPQIIDAKITVD 150 Query: 132 GHYTLQEVEEGLAQHKPVLLFLTHGESSTGV-LQPLDGFGELCHRYKCLLLVDSVASLGG 190 G ++ + E L E+ G+ + FG + ++ D +++ Sbjct: 151 GKRAVKPMREWQLSDNAAYLHYCPNETIDGIAIDETPDFGP-----EVVVTADFSSTILS 205 Query: 191 TPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANF 250 PL + R G+ +Y+G+QK + P G +L+ + K + + ++ Sbjct: 206 APLDVSRYGV--IYAGAQKNIG-PAGLTLVIVREDLLGKAHE----------SCPSILDY 252 Query: 251 WGCDDQPRMYHHTIPVISLYSLRESLA-LIAEQGLENSWRQHREAAAYLHGRLQALGL-- 307 +D M+ +T P + Y L A+ G+ + +++ A L+G + Sbjct: 253 TVLNDNDSMF-NTPPTFAWYLSGLVFKWLKAQGGVAAMHKINQQKAELLYGVIDNSDFYR 311 Query: 308 QLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIE--IMGGLGPSTG 356 + R+ + +D +E GL G Sbjct: 312 NDVAQANRSRMNV-----------PFQLADNTLDKVFLEESFAAGLHALKG 351 >1V2E-A nrPDB Length = 381 Score = 61.3 bits (147), Expect = 6e-10, Method: Composition-based stats. Identities = 65/367 (17%), Positives = 118/367 (32%), Gaps = 43/367 (11%) Query: 30 PSNLPPRIMAAGGLQMIGSMSK-DMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEA 88 PSN PP + + +G + + ++E + F P ++V++ AL Sbjct: 35 PSNPPPPFLLEAVRRALGRQDQYAPPAGLPALREALAEEFAVE-PESVVVTSGATEALYV 93 Query: 89 ALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMT---KDPGGHYTLQEVEEGLAQ 145 L +++ PGD +V + + GA+ + G L +E+ L Sbjct: 94 LLQSLVGPGDEVVVLE--PFFDVYLPDAFLAGAKARLVRLDLTPEGFRLDLSALEKAL-T 150 Query: 146 HKPVLLFLTHGESSTGVL---QPLDGFGELCHRYKCLLLVDSVAS---LGGTPLYMDRQG 199 + L L + TG++ + L+ L + L+ D V G P + Sbjct: 151 PRTRALLLNTPMNPTGLVFGERELEAIARLARAHDLFLISDEVYDELYYGERPRRLREF- 209 Query: 200 IDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRM 259 AP T + + K + R + LA Sbjct: 210 -------------APERTFTVGSAGKRLEATGYRVGWIVGPKEFMPRLAGMRQW------ 250 Query: 260 YHHTIPVISLYSLRESLALIAEQGLENSWRQ-HREAAAYLHGRLQALGLQLFVKDPALRL 318 + P + E+L L +G + R+ +R L G L+A+GL+++V + L Sbjct: 251 TSFSAPTPLQAGVAEALKLARREGFYEALREGYRRRRDLLAGGLRAMGLRVYVPEGTYFL 310 Query: 319 PTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTE 378 G+D +V L + R T E + E Sbjct: 311 MAEL-----PGWDAFRLVEEARVALIPASAFYLEDPPKDLFR---FAFCKTEEELHLALE 362 Query: 379 ALRAALQ 385 L + Sbjct: 363 RLGRVVN 369 >4LW2-A nrPDB Length = 404 Score = 61.3 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 57/348 (16%), Positives = 116/348 (33%), Gaps = 34/348 (9%) Query: 57 MDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNV----LEPGDSFLVGANGIWGQR- 111 + +E + + + T+V + ++ L+PGD +V Sbjct: 68 YEAAREKVAQLLNAPDDKTIVWTRGTTESINMVAQCYARPRLQPGDEIIVSVAEHHANLV 127 Query: 112 -AVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFG 170 + + ++ GA+V + + + + L + +L L + TG L Sbjct: 128 PWLMVAQQTGAKVVKLPLNAQRLPDVDLL-PELITPRSRILALGQMSNVTGGCPDLARAI 186 Query: 171 ELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKM 230 H +++VD P + + ID Y+ S L P G ++ + + M Sbjct: 187 TFAHSAGMVVMVDGAQGAVHFPADVQQLDIDF-YAFSGHKLYGPTGIGVLYGKSELLEAM 245 Query: 231 Y----SRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLEN 286 K + + W + T V + L +L +A+ + Sbjct: 246 SPWLGGGKMVHEVSFDGFTTQSAPWKLEAG------TPNVAGVIGLSAALEWLADYDINQ 299 Query: 287 SWRQHREAAAYLHGRLQAL-GLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDI 345 + R A L G + F + ++ AG D+V+ ++ + I Sbjct: 300 AESWSRSLATLAEDALAKRPGFRSF----RCQDSSLLAFDF-AGVHHSDMVT-LLAEYGI 353 Query: 346 EIMGGLG---PSTGKV-----LRIGLLGCNATRENVDRVTEALRAALQ 385 + G P ++ LR N T+ +VD + A+ AL+ Sbjct: 354 ALRAGQHCAQPLLAELGVTGTLRASFAPYN-TKSDVDALVNAVDRALE 400 >5YII-A nrPDB Length = 313 Score = 61.3 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 50/304 (16%), Positives = 107/304 (35%), Gaps = 33/304 (10%) Query: 52 DMYQIMDEIKEGIQYVFQTRNPLTLVISGSG-HCALEAALVNVLEPGDSFLVGANGIWGQ 110 + +M+E K ++ V ++ G G +N+L G+W Sbjct: 1 EWINVMNETKALMKEVMDIPEGYEILFFGGGASLQFLMVAMNLL--NKKACYLDTGVWAS 58 Query: 111 RAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGES--STGVLQPLDG 168 +A+ E IG V + +YT + E +T + T + + ++ Sbjct: 59 KAIKEAENIG-EVKIIGTSKDKNYT--YIPEYQIPSDYDYFHITTNNTIYGTEIRKDIES 115 Query: 169 FGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKK 228 L+ D + + P+ + + + +Y+G+QK A G +++ + Sbjct: 116 --------PIPLVADMSSDILSKPIDISKYSL--IYAGAQKNCGA-AGVTIVIIKKEILG 164 Query: 229 KMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSW 288 K+ + I + ++ MY +T PVIS++++ ++L I + G Sbjct: 165 KVQRK----------IPIILDYQVHILNNSMY-NTPPVISIFTVNQTLKYIKKIGGLKKI 213 Query: 289 RQ-HREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYD--WRDIVSYVIDHFDI 345 ++ + E A L+ + + R + Y + Y + I Sbjct: 214 QELNEEKARLLYAEIDRNKIFRGTVRKKDRSIMNVCFVMEEQYKQLENEFSEYALQKGII 273 Query: 346 EIMG 349 I G Sbjct: 274 GIKG 277 >3AEO-A nrPDB Length = 389 Score = 55.1 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 37/230 (16%), Positives = 77/230 (33%), Gaps = 26/230 (11%) Query: 80 GSGHCALEAALVNVLEPGDSFLVGANGIWG---QRAVDIGERIGARVHPMTKDPGGHYTL 136 GSG A+ ++ + L+ GD L+ + ++G R G V + + Sbjct: 81 GSGMGAISSSTLAFLQKGD-HLIAGDTLYGCTVSLFTHWLPRFGIEVDLIDTS-----DV 134 Query: 137 QEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMD 196 ++V+ + +++L + T + + G +CH L+VD+ + L Sbjct: 135 EKVKAAWKPN-TKMVYLESPANPTCKVSDIKGIAVVCHERGARLVVDATFTSPCF-LKPL 192 Query: 197 RQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRK--TKPFSFYLDIKWLANFWGCD 254 G DI K +N S K + + + K K + + + C Sbjct: 193 ELGADIALHSVSKYINGHGDVIGGVSSAKTAEDIATIKFYRKDAG---SLMAPMDAFLCA 249 Query: 255 DQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQA 304 + + + L+ + QH + H L++ Sbjct: 250 RGMKTLPIRMQIHMENGLKVA----------KFLEQHEKIVKVNHPGLES 289 >3A9Z-A nrPDB Length = 432 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 45/284 (15%), Positives = 88/284 (30%), Gaps = 53/284 (18%) Query: 138 EVEEGLAQHKPV--LLFLTHGESSTGVLQPLDGFGELCHRYK----------CLLLVDSV 185 EVE+ LA +P L+ + + TGV+ P+ L+ D+ Sbjct: 164 EVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAA 223 Query: 186 ASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIK 245 +LG + ++ G+D L + P + + + K+ Sbjct: 224 QALGKRRVDVEDLGVDFL-TIVGHKFYGP---RIGALYVRGVGKLT-------------P 266 Query: 246 WLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQA- 304 +G + T + L ++ L++E E R+ YL RL+A Sbjct: 267 LYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSEN-CETYEAHMRDIRDYLEERLEAE 325 Query: 305 LGLQLFVKDP---ALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTG----- 356 G ++ + RLP ++ +V + Sbjct: 326 FGKRIHLNSRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGASCHSDHEDRPSP 385 Query: 357 -------------KVLRIGLLGCNATRENVDRVTEALRAALQHC 387 +R+ +G + TR VD + + L+ A+ Sbjct: 386 VLLSCGIPVDVARNAVRLS-VGRSTTRAEVDLIVQDLKQAVNQL 428 >6HRH-B nrPDB Length = 469 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 40/266 (15%), Positives = 86/266 (32%), Gaps = 45/266 (16%) Query: 135 TLQEVEEGLAQHKPVLLFLTHGES---STGVLQPLDGFGELCHRYKCLLLVDSVASLGGT 191 +++ L + P + + E+ G + PL+ ++ H+Y L VD V ++G Sbjct: 188 DPDHLKKLLEKSNPKIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLY 247 Query: 192 --------PLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLD 243 IDI+ KA G + Sbjct: 248 GSRGAGIGERDGIMHKIDIISGTLGKAFGCVGG-----------------------YIAS 284 Query: 244 IKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQ 303 + L + ++ ++P + L ES+ L+ + + R H+ ++ L Sbjct: 285 TRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLM 344 Query: 304 ALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPST---GKVLR 360 GL + P+ +P + V + ++ I + P+ ++LR Sbjct: 345 DRGL-PVIPCPSHIIP----IRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLR 399 Query: 361 IG---LLGCNATRENVDRVTEALRAA 383 + + V+++ A A Sbjct: 400 LAPSPHHSPQMMEDFVEKLLLAWTAV 425 >1M6S-A nrPDB Length = 347 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 41/216 (18%), Positives = 79/216 (36%), Gaps = 21/216 (9%) Query: 35 PRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVL 94 + A +G D+Y I E + +T + SG + +++ Sbjct: 18 EEMRKAMAQAEVG---DDVYGEDPTINELERLAAETFGKEAALFVPSGTMGNQVSIMAHT 74 Query: 95 EPGDSFLVGANG-IWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQH-----KP 148 + GD ++ A+ I+ + G HP+ G +V + + + Sbjct: 75 QRGDEVILEADSHIFWYEVGAMAVLSGVMPHPV-PGKNGAMDPDDVRKAIRPRNIHFPRT 133 Query: 149 VLLFL--THGESSTGVLQPLDGFGELC---HRYKCLLLVDSV----ASLG-GTPLYMDRQ 198 L+ + TH S G + PL+ E+C + + +D AS+ G P+ Sbjct: 134 SLIAIENTHNR-SGGRVVPLENIKEICTIAKEHGINVHIDGARIFNASIASGVPVKEYAG 192 Query: 199 GIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRK 234 D + K L AP G+ ++ D ++ +RK Sbjct: 193 YADSVMFCLSKGLCAPVGSVVVGDRDFIERARKARK 228 >6ENZ-A nrPDB Length = 530 Score = 52.0 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 57/312 (18%), Positives = 108/312 (34%), Gaps = 59/312 (18%) Query: 110 QRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHK-----PVLLFLTHGESSTGVLQ 164 ++A V+ + D G +++E+ + Q + P L+ T G + G Sbjct: 232 KKAASFLGIGTQNVYFVETDGRGKMIPEDLEKQIWQARQEGAVPFLVCATSGTTVLGAFD 291 Query: 165 PLDGFGELCHRYKCLLLVDSVASLGGTPLYMDR--------QGIDILYSGSQKALNAPPG 216 PLD E+C R+ L VD+ S GG+ L + D + K L A G Sbjct: 292 PLDEIAEVCERHGLWLHVDA--SWGGSALVSRKHRRLLHGIHRADSVAWNPHKMLMA--G 347 Query: 217 TSLISFSDKAKKKMYSRKTKPFSFYL-------DIKWLA--NFWGCDDQPRMYHHTIPVI 267 + K K + + + YL D+ + C +P + + Sbjct: 348 IQCSALLVKDKSDLLKKCYSAKATYLFQQDKFYDVSYDTGDKSIQCSRRPDAFKFWMTWK 407 Query: 268 SLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQAL-GLQLFVKDPALRLPTVTTVAV 326 +L + GLE + + YL ++ G +L ++ V + Sbjct: 408 ALGT----------SGLEERVNRAFALSRYLVDEIKKREGFKLLMEPE---YTNVCFWYI 454 Query: 327 P-------AGYDWRD--------IVSYVIDHFDIEIMGGLGPSTGKV--LRIGLLGCNAT 369 P G ++ I ++ + + G P GKV R ++ + Sbjct: 455 PPSLREMEEGPEFWRKLSLVAPAIKEKMMKKGSLML--GYQPHRGKVNFFRQVVISPQVS 512 Query: 370 RENVDRVTEALR 381 RE++D + + + Sbjct: 513 REDMDFLLDEID 524 >3TQX-A nrPDB Length = 399 Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 45/274 (16%), Positives = 96/274 (35%), Gaps = 41/274 (14%) Query: 122 RVHPMTKDPGGHYTLQE-VEEGLAQ-HKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCL 179 + L+ ++E + + L+ S G++ L +L +Y L Sbjct: 148 KAQRYRYKNNAMGDLEAKLKEADEKGARFKLIATDGVFSMDGIIADLKSICDLADKYNAL 207 Query: 180 LLVDSVASLG-------GTPLYMD-RQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMY 231 ++VD ++G GTP Y +DIL KAL G Sbjct: 208 VMVDDSHAVGFIGENGRGTPEYCGVADRVDILTGTLGKALGGASG--------------- 252 Query: 232 SRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQH 291 + K + + +P ++ +T+ + + + + L L+ +G + +Q Sbjct: 253 -------GYTSGHKEIIEWLRNRSRPYLFSNTVAPVIVATSLKVLELLKTEGPQLR-KQL 304 Query: 292 REAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGL 351 +E + Y ++ LG QL + P + V + ++ +++ + Sbjct: 305 QENSRYFRAGMEKLGFQLVPGN----HPII-PVMLGDAQLATNMADHLLQEGIYVVGFSY 359 Query: 352 G--PSTGKVLRIGLLGCNATRENVDRVTEALRAA 383 P +R+ + T++ +DR EA Sbjct: 360 PVVPMGKARIRV-QMSAVHTQQQLDRAIEAFGQV 392 >5V1X-E nrPDB Length = 501 Score = 49.3 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 34/224 (15%), Positives = 71/224 (31%), Gaps = 18/224 (8%) Query: 31 SNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAAL 90 A + + ++DE + + + + T+V + + L Sbjct: 66 LRSYQTAAEARPCPFLRYQTPV---LLDESRAAVANLLKVP-VETVVFVANATMGVNTVL 121 Query: 91 VNVL---EPGDSFLV--GANGIWGQRAVDIGER----IGARVHPMTKDPGGHYTLQEVEE 141 N++ + D L G G+ + E + +R P+ + + Sbjct: 122 RNIVWSADGKDEILYFDTIFGACGKTIDYVIEDKRGIVSSRCIPLIYPAEDDDVVAAFRD 181 Query: 142 GLAQHK-----PVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMD 196 + + + P L + S GV P + ++C + + VD +G L + Sbjct: 182 AIKKSREEGKRPRLAVIDVVSSMPGVRFPFEDIVKICKEEEIISCVDGAQGIGMVDLKIT 241 Query: 197 RQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF 240 D L S K L P G ++ + + + S F Sbjct: 242 ETDPDFLISNCHKWLFTPRGCAVFYVPVRNQHLIRSTLPTSHGF 285 >3GZD-A nrPDB Length = 440 Score = 49.3 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 31/179 (17%), Positives = 60/179 (33%), Gaps = 30/179 (16%) Query: 138 EVEEGLAQHKP--VLLFLTHGESSTGVLQPLDGFGELCHRYK----------CLLLVDSV 185 EV++ LA +P L+ + + TG++ P+ + L+ D+ Sbjct: 171 EVDDILAAVRPTTRLVTIMLANNETGIVMPVPEISQRIKALNQERVAAGLPPILVHTDAA 230 Query: 186 ASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIK 245 +LG + ++ G+D L + P +Y R F+ Sbjct: 231 QALGKQRVDVEDLGVDFL-TIVGHKFYGP-----------RIGALYIRGLGEFT-----P 273 Query: 246 WLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQA 304 +G + T + L ++ L+ + E R+ YL RL+A Sbjct: 274 LYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQN-CEAYEAHMRDVRDYLEERLEA 331 >6EEI-A nrPDB Length = 490 Score = 48.9 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 28/164 (17%), Positives = 54/164 (32%), Gaps = 31/164 (18%) Query: 49 MSKDMYQIMDEIKE------GIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFL- 101 S ++ + + + F ++ VI GS EA LV ++ D L Sbjct: 118 TSPAATELEMIVLDWVAKLLNLPEQFMSKGNGGGVIQGSAS---EAVLVVLIAARDKVLR 174 Query: 102 -VGANG-----IWG--------QRAVDIGERIGARVHPM--TKDPGGHYTLQEVEEGLAQ 145 VG N ++ Q+A I + + ++E +++ Sbjct: 175 SVGKNALEKLVVYSSDQTHSALQKACQIAGIHPENCRVLTTDSSTNYALRPESLQEAVSR 234 Query: 146 HK-----PVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDS 184 P L G +S+ + PL G++ + VD+ Sbjct: 235 DLEAGLIPFFLCANVGTTSSTAVDPLAALGKIANSNGIWFHVDA 278 >4P3M-A nrPDB Length = 429 Score = 48.6 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 55/305 (18%), Positives = 99/305 (32%), Gaps = 44/305 (14%) Query: 33 LPPRIMAAGGLQMIGSMSK-----------DMYQIMDE-IKEGIQYVFQTRNPLTLVISG 80 PR+M A G Q+ ++ + + + E + +F V Sbjct: 39 TSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDVAESLAIERAKSLFGAD--YANVQPH 96 Query: 81 SGHCALEAALVNVLEPGDSFLVGANGIWGQRA----VDIGERIGARVHPMTKDPGGHYTL 136 SG A A + PGD+ L + G V ++ V G Sbjct: 97 SGSQANAAVYQALCAPGDTILGMSLAHGGHLTHGSHVSFSGKMYNAVQYGITPETGILDY 156 Query: 137 QEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDS--VASLGGTPLY 194 E+E +HKP ++ S G++ F E+ + L VD VA L LY Sbjct: 157 AEIERLAVEHKPTMIIAGFSAYS-GIV-DWAKFREIADKVGAYLFVDMAHVAGLVAAGLY 214 Query: 195 MDRQG-IDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGC 253 + D++ + + K L P G +++ +++A +K + P G Sbjct: 215 PNPVPFADVVTTTTHKTLGGPRGGLILAKANEAIEKKLNSAVFP--------------GQ 260 Query: 254 DDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKD 313 P + + + + AE +Q + A + A G ++ Sbjct: 261 QGGPL-------MHVIAAKAVAFKECAEPEFAVYQQQVLDNAKAMVKSFLARGYKIVSGG 313 Query: 314 PALRL 318 L Sbjct: 314 TENHL 318 >2CB1-A nrPDB Length = 412 Score = 47.8 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 33/155 (21%), Positives = 59/155 (38%), Gaps = 14/155 (9%) Query: 58 DEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQ---RAVD 114 ++E ++ + L V+ SG A AAL+ +L PGD V A G++GQ Sbjct: 59 KALEERLKAL---EGALEAVVLASGQAATFAALLALLRPGDEV-VAAKGLFGQTIGLFGQ 114 Query: 115 IGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCH 174 + +G V + + + V E L+ K +F+ + ++ L+ L Sbjct: 115 VLSLMGVTVRYVDPE------PEAVREALS-AKTRAVFVETVANPALLVPDLEALATLAE 167 Query: 175 RYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQK 209 L+VD+ G G ++ K Sbjct: 168 EAGVALVVDNTFGAAGALCRPLAWGAHVVVESLTK 202 >1FC4-A nrPDB Length = 401 Score = 47.8 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 49/268 (18%), Positives = 87/268 (32%), Gaps = 45/268 (16%) Query: 135 TLQEVEEGLAQHKP-----VLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLG 189 +QE+E L + + VL+ S GV+ L G +L +Y L++VD ++G Sbjct: 160 DMQELEARLKEAREAGARHVLIATDGVFSMDGVIANLKGVCDLADKYDALVMVDDSHAVG 219 Query: 190 -------GTPLYMDRQG-IDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFY 241 G+ Y D G +DI+ KAL G ++ K+ + + + + Sbjct: 220 FVGENGRGSHEYCDVMGRVDIITGTLGKALGGASG----GYTAARKEVVEWLRQRSRPYL 275 Query: 242 LDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGR 301 ++ + + + E G E + A + Sbjct: 276 FSNSL-------------------APAIVAASIKVLEMVEAGSELR-DRLWANARQFREQ 315 Query: 302 LQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGK-VLR 360 + A G L D A + V + + + I + G P K R Sbjct: 316 MSAAGFTLAGADHA-----IIPVMLGDAVVAQKFARELQKE-GIYVTGFFYPVVPKGQAR 369 Query: 361 IGL-LGCNATRENVDRVTEALRAALQHC 387 I + T E + R EA + Sbjct: 370 IRTQMSAAHTPEQITRAVEAFTRIGKQL 397 >2CTZ-A nrPDB Length = 421 Score = 46.2 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 34/202 (16%), Positives = 72/202 (35%), Gaps = 10/202 (4%) Query: 16 KPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGI-QYVFQTRNPL 74 +P ++ Q+ + P S + A L + +IM+ + + + + Sbjct: 15 EPTTLSRQVPIYPTTSYVFKSPEHAANLFALKEFGNIYSRIMNPTVDVLEKRLAALEGGK 74 Query: 75 TLVISGSGHCALEAALVNVLEPGDSFLVGAN---GIWGQRAVDIGERIGARVHPMTKDPG 131 + + SGH A AL + + GD+ + N G + Q +R+G V +++ Sbjct: 75 AALATASGHAAQFLALTTLAQAGDNIVSTPNLYGGTFNQ-FKVTLKRLGIEVRFTSREE- 132 Query: 132 GHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGT 191 +E L K ++ + + L+ + L+VD+ +GG Sbjct: 133 ---RPEEFL-ALTDEKTRAWWVESIGNPALNIPDLEALAQAAREKGVALIVDNTFGMGGY 188 Query: 192 PLYMDRQGIDILYSGSQKALNA 213 L G ++ K + Sbjct: 189 LLRPLAWGAALVTHSLTKWVGG 210 >2JIS-A nrPDB Length = 515 Score = 45.1 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 61/412 (14%), Positives = 120/412 (29%), Gaps = 65/412 (15%) Query: 22 NQLLLGPGPSNLPPRIMAAGGL--QMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVIS 79 NQL G P L RI+ Q ++ + +E+ ++ + + + Sbjct: 113 NQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVGWSSGDGIFCP 172 Query: 80 GSGHCALEAA-------LVNVLEPGDSFLVGANGIWGQRAVDIGERIGAR--------VH 124 G + A + + G L ++ + + GA V Sbjct: 173 GGSISNMYAVNLARYQRYPDCKQRGLRTLPPLA-LFTSKECHYSIQKGAAFLGLGTDSVR 231 Query: 125 PMTKDPGGHYTLQEVEEGLAQHK-----PVLLFLTHGESSTGVLQPLDGFGELCHRYKCL 179 + D G +++E + + P L+ T G + G PL+ ++C R+ Sbjct: 232 VVKADERGKMVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLW 291 Query: 180 LLVDSVASLGGTPLYMDRQG---------IDILYSGSQKALNAPPGTSLISFSDKAKKKM 230 L VD+ G + + + D + K L A S + D + + Sbjct: 292 LHVDAA---WGGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDTS-NLL 347 Query: 231 YSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIA------EQGL 284 S+ + V+ + L L +QGL Sbjct: 348 KRCHGSQASYLFQQDKFYDVALDTGDK--------VVQCGRRVDCLKLWLMWKAQGDQGL 399 Query: 285 ENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVP------AGYDWRD---- 334 E Q A YL ++ V +P + P D+ + Sbjct: 400 ERRIDQAFVLARYLVEEMKKREGFELVMEPE-FVNVCFWFVPPSLRGKQESPDYHERLSK 458 Query: 335 ----IVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRA 382 + ++ + I + G R+ + T ++D + L Sbjct: 459 VAPVLKERMVKEGSMMIGYQPHGTRGNFFRVVVANSALTCADMDFLLNELER 510 >3VK2-A nrPDB Length = 398 Score = 44.7 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 27/173 (15%), Positives = 62/173 (35%), Gaps = 19/173 (10%) Query: 47 GSMSKDMYQIMDEIKEGIQYVFQT-RNPLTLVISGSGHCALEAALVNVLEPGDSFLVGAN 105 G +I + ++ + + SG A+ + L +L PGD L+G N Sbjct: 56 GHF---YSRISNPTLNLLEARMASLEGGEAGLALASGMGAITSTLWTLLRPGDEVLLG-N 111 Query: 106 GIWGQRAVDI---GERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGV 162 ++G + G ++ + LQ +E + +++ + Sbjct: 112 TLYGHTFAFLHHGIGEFGVKLRHVDMA-----DLQALEAAMTPA-TRVIYFESPANPNMH 165 Query: 163 LQPLDGFGELCHRYKCLLLVDSVASLGGTPL--YMDRQGIDILYSGSQKALNA 213 + + G ++ ++ ++VD+ TP G D++ + K L+ Sbjct: 166 MADIAGVAKIARKHGATVVVDNTY---CTPYLQRPLELGADLVVHSATKYLSG 215 >3CAI-A nrPDB Length = 406 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 44/249 (17%), Positives = 82/249 (32%), Gaps = 27/249 (10%) Query: 112 AVDIGERIGARVH--PMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGF 169 + R GA+V + + G T Q E L L+ + + G + L Sbjct: 130 WLRAAHRYGAKVKWAEVDIETGELPTWQW--ESLISKSTRLVAVNSASGTLGGVTDLRAM 187 Query: 170 GELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKK 229 +L H L++VD A+ L + D++ + + A PP + F D + Sbjct: 188 TKLVHDVGALVVVDHSAAAPYRLLDIRETDADVV-TVNAHAWGGPP-IGAMVFRDPSV-- 243 Query: 230 MYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWR 289 F + + + V++ +L A Sbjct: 244 -----MNSFGSVSTNPYATGPARLEIGVHQFGLLAGVVASIEYLAALDESARGSRRERLA 298 Query: 290 QHREAA--------AYLHGRLQALGLQLFVKDPALRLPTVT--TVAVPAGYDWRDIVSYV 339 ++A YL L++L L + + P ++P V+ VPA +V + Sbjct: 299 VSMQSADAYLNRVFDYLMVSLRSLPLVMLIGRPEAQIPVVSFAVHKVPA----DRVVQRL 354 Query: 340 IDHFDIEIM 348 D+ + I Sbjct: 355 ADNGILAIA 363 >3HQT-A nrPDB Length = 409 Score = 43.5 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 45/293 (15%), Positives = 86/293 (29%), Gaps = 34/293 (11%) Query: 100 FLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESS 159 ++ + GAR P H + + +H P ++ + S+ Sbjct: 139 ICQPNTNVYIDFFAHMSLWEGARYANAQAHPFMHNNCDHLRMLIQRHGPGIIVVDSIYST 198 Query: 160 TGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSL 219 G + PL + + C LLVD SLG + P G L Sbjct: 199 LGTIAPLAELVNISKEFGCALLVDESHSLGT---------------------HGPNGAGL 237 Query: 220 ISFSDKAKKK--MYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLA 277 ++ ++ M + K F++ W N Y L L Sbjct: 238 LAELGLTREVHFMTASLAKTFAYRAGAIWCNNEVNRCVPFISYPAIFSSTLLPYEAAGLE 297 Query: 278 LIAE--QGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDI 335 E + +N + A L L LGL + + + + + + Sbjct: 298 TTLEIIESADNRRQHLDRMARKLRIGLSQLGLTIRSESQ------IIGLETGDERNTEKV 351 Query: 336 VSYVIDH--FDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRAALQH 386 Y+ + F ++R+ L + E + ++ E A+ + Sbjct: 352 RDYLESNGVFGSVFCRPATSKNKNIIRLSL-NSDVNDEQIAKIIEVCSDAVNY 403 >4Q6R-A nrPDB Length = 511 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 39/192 (20%), Positives = 77/192 (40%), Gaps = 30/192 (15%) Query: 134 YTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGT-- 191 ++ + ++++ +L+ T + GV+ P+ +L +YK L VD+ LGG Sbjct: 210 VDVRAMRRAISRNTAMLVCST-PQFPHGVIDPVPEVAKLAVKYKIPLHVDAC--LGGFLI 266 Query: 192 ------------PLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFS 239 P +G+ + + + K AP G+SL+ +SDK K + + Sbjct: 267 VFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDK--------KYRNYQ 318 Query: 240 FYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLH 299 F++D W + I + +L E G + +Q + A +L Sbjct: 319 FFVDTDWQGGIYASPTIAGSRPGGISA----ACWAALMHFGENGYVEATKQIIKTARFLK 374 Query: 300 GRLQAL-GLQLF 310 L+ + G+ +F Sbjct: 375 SELENIKGIFVF 386 >5K8B-A nrPDB Length = 403 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 41/292 (14%), Positives = 95/292 (32%), Gaps = 24/292 (8%) Query: 59 EIKEGIQYVFQTRNPLTLVISGSGHCALE-AALVNVLEPGDSFLVGANGIWGQRAVDIGE 117 + ++ Q + + N + SG AL+ A + + GD +V V+ Sbjct: 38 KTRDMEQLLCEKMNVKHAHLLSSGTAALQTAMMAAGIGAGDEVIVPPFTFVAS--VEAIF 95 Query: 118 RIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYK 177 GA D + + +E + + + L H G + +D +C ++ Sbjct: 96 MAGAVPIFAEIDETLCLSPEGIE-AVITPRTKAINLVHM---CGSMAKMDEIKAICKKHN 151 Query: 178 CLLLVDSVASLGGTPLYMDRQG----IDILYSGSQKALNAPPGTSLISFSDKAKKKMYSR 233 +LL D+ ++GG+ G + S K + G ++I+ + + + Sbjct: 152 LVLLEDACQAIGGS-YKGQALGTIGDVGCYSFDSVKTITCGEGGAVITNNTEIYDNAHMF 210 Query: 234 KTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHRE 293 + G D + + + +L L + L+ R+ Sbjct: 211 SDHGH----------DHIGKDRGAESHPIMGLNFRISEMNAALGLAQLRKLDTIIDIQRK 260 Query: 294 AAAYLHGRLQALGLQLF--VKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHF 343 + + ++ F + DP + +P ++I + + Sbjct: 261 NKKAIKDAMASIPEVSFREIPDPEGDSAGFLSFMLPTEARTQEISKKLAANG 312 >2OKK-A nrPDB Length = 497 Score = 42.0 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 47/298 (15%), Positives = 93/298 (31%), Gaps = 54/298 (18%) Query: 123 VHPMTKDPGGHYTLQEVEEGLAQHK-----PVLLFLTHGESSTGVLQPLDGFGELCHRYK 177 V + D G ++E + + K P L+ T G + G PL ++C +YK Sbjct: 212 VILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYK 271 Query: 178 CLLLVDSVASLGGTPLYMDRQGI------DILYSGSQKALNAPPGTSLISFSDKAKKKMY 231 + VD+ G + + + + K + P S + ++ M Sbjct: 272 IWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGL--MQ 329 Query: 232 SRKTKPFSFYL-----------------------DIKWLANFWGCDDQPRMYHHTIPVIS 268 + S+ D+ L W H V Sbjct: 330 NCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAH---VDK 386 Query: 269 LYSLRESLALIAE--QGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAV 326 L E L I + +G E + + + L+ +D R+ ++ VA Sbjct: 387 CLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWYIPPS-LRTL-EDNEERMSRLSKVAP 444 Query: 327 PAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKV--LRIGLLGCNATRENVDRVTEALRA 382 ++ + + ++ P KV R+ + AT +++D + E + Sbjct: 445 --------VIKARMMEYGTTMVS-YQPLGDKVNFFRMVISNPAATHQDIDFLIEEIER 493 >3EUC-A nrPDB Length = 367 Score = 41.6 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 16/131 (12%), Positives = 43/131 (32%), Gaps = 7/131 (5%) Query: 58 DEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGE 117 + ++ ++ V Q + +++ + + PG + G + Sbjct: 70 EALRAKLKEVMQVPAGMEVLLGNGSDEIISMLALAAARPGAKVMAPVPGFVMYAMS--AQ 127 Query: 118 RIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYK 177 G + + +A+H+P +++L + + TG L + + Sbjct: 128 FAGLEFVGVPLRADFTLDRGAMLAAMAEHQPAIVYLAYPNNPTGNLFDAADMEAIVRAAQ 187 Query: 178 C-----LLLVD 183 L++VD Sbjct: 188 GSVCRSLVVVD 198 >4RIT-B nrPDB Length = 486 Score = 41.6 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 56/325 (17%), Positives = 104/325 (32%), Gaps = 44/325 (13%) Query: 37 IMAAGGLQMIG-SMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCA-LEAALV--- 91 + AA M+ MS ++ + I +F V++ G A L+A V Sbjct: 108 VAAAVNNNMLSLEMSPSFSRLETLLLRAIAGLFGLGEQAGGVLTSGGSLANLQALAVARN 167 Query: 92 ---NVLEPGDSFLVGANGIWG--------QRAVDIGERIGARVHPMTKDPGGHYTLQEVE 140 + +EPG + L I+ Q+A + A V P+ +++ Sbjct: 168 VAFDSVEPGITGLAQRPVIFASEAAHTSLQKAAMLLGLGTAAVIPVRATADSRMDPEDLR 227 Query: 141 EGLAQHK-----PVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYM 195 + Q + P + T G ++TG + PL G + + VD+ + GG ++ Sbjct: 228 ARIDQARGAGQHPFCVVATAGTTTTGNIDPLAEIGAIAREHGLWFHVDA--AYGGALVFS 285 Query: 196 D--RQGI------DILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWL 247 + R + D + QK L +++ F D + R + + Y+ Sbjct: 286 ERHRWRLAGIEQADSITFNPQKWLYVAKTCAMVLFRDAG---VLERAFRIPAPYMRATDG 342 Query: 248 ANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGL 307 G H + L +L I +QG A + ++ Sbjct: 343 FINLGEIGVQGTRHA-----DVVKLWLTLQHIGQQGYARLIDDGYRLAERVVEGVRQRPF 397 Query: 308 QLFVKDPALRLPTVTTVAVPAGYDW 332 + V DW Sbjct: 398 LRLAGEID-----TNIVCFRGEPDW 417 >1SVV-A nrPDB Length = 359 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 50/275 (18%), Positives = 90/275 (32%), Gaps = 29/275 (10%) Query: 31 SNLPPRIMAAGGLQMIGSMSKDMYQIM-DEIKEGIQYVFQTRNPLTLVISGSGHCALEAA 89 + P+I+ + + + I + + + ISG G A Sbjct: 24 VGMHPKILDLMARDNMTQHAGYGQDSHCAKAARLIGELLERPDADVHFISG-GTQTNLIA 82 Query: 90 LVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHK-- 147 L P ++ + G E G +V G + ++E L +++ Sbjct: 83 CSLALRPWEAVIATQLGHISTHETGAIEATGHKVVTAPCPDGK-LRVADIESALHENRSE 141 Query: 148 ----PVLLFLTHGESSTGV---LQPLDGFGELCHRYKCLLLVDS--VASLGGTPL----- 193 P L++++ + G Q L+ C + L +D +AS +P+ Sbjct: 142 HMVIPKLVYIS-NTTEVGTQYTKQELEDISASCKEHGLYLFLDGARLASALSSPVNDLTL 200 Query: 194 -YMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWG 252 + R D+ Y G+ KA G +LI +D A K K +A W Sbjct: 201 ADIARL-TDMFYIGATKA-GGMFGEALIILND-ALKPNARHLIKQRG-----ALMAKGWL 252 Query: 253 CDDQPRMYHHTIPVISLYSLRESLALIAEQGLENS 287 Q + L + +A I + GLE Sbjct: 253 LGIQFEVLMKDNLFFELGAHSNKMAAILKAGLEAC 287 >4BMK-A nrPDB Length = 442 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 42/259 (16%), Positives = 88/259 (33%), Gaps = 36/259 (13%) Query: 57 MDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIG 116 E+++ ++ + T ++ +G+ A + + G+ ++ A+ ++ G Sbjct: 133 HMEVEQALRDFYGTTGA---IVFSTGYMANLGIISTLAGKGEYVILDAD---SHASIYDG 186 Query: 117 ERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRY 176 + G + L + L + L+ L S G + PL + ++ Sbjct: 187 CQQG-NAEIVRFRHNSVEDLDKRLGRLPKEPAKLVVLEGVYSMLGDIAPLKEMVAVAKKH 245 Query: 177 KCLLLVDSVASLG-----GTPLYMDRQGIDILYSGSQKALNAPPGT-SLISFSDKAKKKM 230 ++LVD S+G G +Y + QG++ +A GT S+ K + Sbjct: 246 GAMVLVDEAHSMGFFGPNGRGVY-EAQGLEGQIDFVVGTFSASVGTVGGFVVSNHPKFEA 304 Query: 231 YSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQ 290 +P+ F + S+ L + + Sbjct: 305 VRLACRPYIFTASLPPSVV-------------ATATTSIRKLMTA---------HEKRER 342 Query: 291 HREAAAYLHGRLQALGLQL 309 A LHG L+A+G +L Sbjct: 343 LWSNARALHGGLKAMGFRL 361 >4J5U-A nrPDB Length = 420 Score = 38.5 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 53/300 (17%), Positives = 97/300 (32%), Gaps = 47/300 (15%) Query: 33 LPPRIMAAGGLQMIGSM-----SKDMYQIMDEI-------KEGIQYVFQTRNPLTLVISG 80 + P ++ A G + SK Y +E+ E ++ +F + V Sbjct: 39 VSPAVLEAQGALLTNKYAEGYPSKRFYNGCEEVDKAENLAIERVKKLFNCK--YANVQPH 96 Query: 81 SGHCALEAALVNVLEPGDSFL---VGANGIWGQRAV-DIGERIGARVHPMTKDPGGHYTL 136 SG A +A + +L+PGD+ L + + G A ++ + V Sbjct: 97 SGSQANQAVYLALLQPGDTVLGMSLDSGGHLTHGAAPNMSGKWFNAVSYSVNKETYLIDY 156 Query: 137 QEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMD 196 E+E HKP LL + F E+ + + D +A + G + Sbjct: 157 DEIERLADLHKPKLLIAGFSAYPRNI--DFAKFREIVDKVGAYFMAD-IAHIAGLVATGE 213 Query: 197 RQG----IDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWG 252 Q + S + K L P G ++S ++ K+ S A F G Sbjct: 214 HQSPIPYAHAVTSTTHKTLRGPRGGLILSNDEEIGHKINS---------------ALFPG 258 Query: 253 CDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVK 312 P + + + + + ++ +Q A L LQ G + Sbjct: 259 LQGGPL-------MHIIAAKAVAFLENLQPEYKSYIQQVISNAKALASSLQERGYDILTG 311 >4OBV-D nrPDB Length = 490 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 18/82 (21%), Positives = 32/82 (39%), Gaps = 9/82 (10%) Query: 122 RVHPMTKDPGGHYTLQE--VEEGLAQHK-----PVLLFLTHGESSTGVLQPLDGFGELCH 174 H+ + +EE + K P ++ T G ++TG + PL LC Sbjct: 206 DSRIRRIPTNSHFQMDTTKLEEAIETDKKSGYIPFVVIGTAGTTNTGSIDPLTEISALCK 265 Query: 175 RYKCLLLVDSV--ASLGGTPLY 194 ++ +D AS+ +P Y Sbjct: 266 KHDMWFHIDGAYGASVLLSPKY 287 >5O5C-A nrPDB Length = 519 Score = 37.4 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 22/73 (30%), Positives = 30/73 (41%), Gaps = 10/73 (13%) Query: 113 VDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHK-PVLLFLTHGESSTGVLQPLDGFGE 171 VD ER V + QEV+ L Q PV + T G + G + PL E Sbjct: 236 VDYDERYRMDVDCLK---------QEVQRCLQQGLIPVAVVATSGTTDFGSIDPLGAISE 286 Query: 172 LCHRYKCLLLVDS 184 LC + + VD+ Sbjct: 287 LCKHHGMWMHVDA 299 >3ASB-A nrPDB Length = 400 Score = 37.0 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 54/309 (17%), Positives = 102/309 (33%), Gaps = 45/309 (14%) Query: 90 LVNVLEPGDSFLV--GANGIWGQRAVDIGERIGA-RVHPMTKDPGGHYTLQEVEEGLAQH 146 L++ P + + + + +DI GA + + + + E+ Sbjct: 111 LLSFFGPNQTVAIQDPSYPAY----LDIARLTGAKEIIALPCLQENAFFPEFPEDTHID- 165 Query: 147 KPVLLFLTHGESSTGVLQPLDGFGELCH---RYKCLLLVDSVASL----GGTPLYMDRQG 199 +L L + TG + D + H ++ L+L D+ S P + Sbjct: 166 ---ILCLCSPNNPTGTVLNKDQLRAIVHYAIEHEILILFDAAYSTFISDPSLPKSIFEIP 222 Query: 200 IDILYSGSQ-KALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPR 258 D + + + + P G + I + T Y D ++ W Sbjct: 223 -DARFCAIEINSFSKPLGFAGIRL---GWTVIPQELT-----YADGHFVIQDWERFLSTT 273 Query: 259 MYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRL 318 +IP S+ E + +RE + L L A G ++F + Sbjct: 274 FNGASIPAQEAGVAGLSILPQLE-----AIHYYRENSDLLRKALLATGFEVFGGE---HA 325 Query: 319 PTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGK----VLRIGLLGCNATRENVD 374 P + A RD+ + + + I I G+G G+ +R LG RE++ Sbjct: 326 PYLWVKPTQANISDRDLFDFFLREYHIAITPGIG--FGRSGSGFVRFSSLG---KREDIL 380 Query: 375 RVTEALRAA 383 E L+ A Sbjct: 381 AACERLQMA 389 >1M4N-A nrPDB Length = 435 Score = 37.0 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 52/304 (17%), Positives = 103/304 (33%), Gaps = 37/304 (12%) Query: 35 PRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVL 94 I A L + M + I+ T +P LV++ A E + + Sbjct: 73 ESIFAELALFQDYHGLPAFKKAMVDFMAEIRGNKVTFDPNHLVLTAGATSANETFIFCLA 132 Query: 95 EPGDSFLVGANGIWG-QRAVDIGERIGARVHPMTK--DPGGHYTLQEVEEGLAQHKPVLL 151 +PG++ L+ G R + R G + P+ G T +EE + + L Sbjct: 133 DPGEAVLIPTPYYPGFDRDLKW--RTGVEIVPIHCTSSNGFQITETALEEAYQEAEKRNL 190 Query: 152 FLTHGESSTGVL--QPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQK 209 + GVL P + G R + LL+ V G + D +YSG+ Sbjct: 191 RV------KGVLVTNPSNPLGTTMTRNELYLLLSFVEDKGIHLIS------DEIYSGT-- 236 Query: 210 ALNAPPGTSLISF--------SDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYH 261 A ++P S++ + + ++++ + L + + DD Sbjct: 237 AFSSPSFISVMEVLKDRNCDENSEVWQRVHVVYSLSKDLGLPGFRVGAIYSNDDMVVAAA 296 Query: 262 HTIPVISLYS-----LRESL---ALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKD 313 + L S L ++ + + + + ++ ++ L LQ G+ + Sbjct: 297 TKMSSFGLVSSQTQHLLSAMLSDKKLTKNYIAENHKRLKQRQKKLVSGLQKSGISCLNGN 356 Query: 314 PALR 317 L Sbjct: 357 AGLF 360 >6HNB-A nrPDB Length = 491 Score = 37.0 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 27/140 (19%), Positives = 58/140 (41%), Gaps = 12/140 (8%) Query: 51 KDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQ 110 + Q + E + + V +++S A ++ L GD+ LV + Sbjct: 112 PEFLQFIKEHTDMVHKV--PYENWDVIVSVGNTEAWDSTLRTFCSKGDTILVEEY-TFSS 168 Query: 111 RAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQ---HKPVLLF-LTHGESSTGVL--- 163 A++ G P+T D G +++EE +++ +KP L+ + G++ TG Sbjct: 169 -ALESANGQGVNTVPVTMDEFGII-PEKLEELMSRWVGNKPKFLYTICTGQNPTGSSLSA 226 Query: 164 QPLDGFGELCHRYKCLLLVD 183 + ++ +Y L++ D Sbjct: 227 ERRKQIYDIACKYDFLIIED 246 >3G8M-A nrPDB Length = 417 Score = 37.0 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 34/175 (19%), Positives = 62/175 (35%), Gaps = 35/175 (20%) Query: 33 LPPRIMAAGGLQMIGSMSK-----------DMYQIMDE-IKEGIQYVFQTRNPLTLVISG 80 PR+M A G Q+ ++ + I+++ + + +F V Sbjct: 39 TSPRVMQAQGSQLTNKFAEGYPGKRYYGGCEYVDIVEQLAIDRAKELFGAD--YANVQPH 96 Query: 81 SGHCALEAALVNVLEPGDSFL---VGANGI--------WGQRAVDIGERIGARVHPMTKD 129 SG A A +LEPGD+ L + G + + +I G Sbjct: 97 SGSQANFAVYTALLEPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVP-YGIDAT----- 150 Query: 130 PGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDS 184 GH ++E+ +HKP ++ + + +GV+ E+ L VD Sbjct: 151 --GHIDYADLEKQAKEHKPKMI-IGGFSAYSGVV-DWAKMREIADSIGAYLFVDM 201 >1IAY-A nrPDB Length = 428 Score = 36.6 bits (83), Expect = 0.017, Method: Composition-based stats. Identities = 27/159 (16%), Positives = 60/159 (37%), Gaps = 15/159 (9%) Query: 39 AAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGD 98 A + + + + E + +P +V++G A E + + +PGD Sbjct: 74 KAIANFQDYHGLPEFRKAIAKFMEKTRGGRVRFDPERVVMAGGATGANETIIFCLADPGD 133 Query: 99 SFLVGA--NGIWGQRAVDIGERIGARVHPMTKDPGGHYTL--QEVEEGLAQH-----KPV 149 +FLV + + + D+ R G ++ P+ + ++ + + V+E K Sbjct: 134 AFLVPSPYYPAFNR---DLRWRTGVQLIPIHCESSNNFKITSKAVKEAYENAQKSNIKVK 190 Query: 150 LLFLTHGESSTGVLQP---LDGFGELCHRYKCLLLVDSV 185 L LT+ + G L +++ L+ D + Sbjct: 191 GLILTNPSNPLGTTLDKDTLKSVLSFTNQHNIHLVCDEI 229 >3E9K-A nrPDB Length = 465 Score = 36.6 bits (83), Expect = 0.017, Method: Composition-based stats. Identities = 15/92 (16%), Positives = 32/92 (34%), Gaps = 3/92 (3%) Query: 124 HPMTKDPGG-HYTLQEVEEGLAQ--HKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL 180 + G ++++ E + + ++ + TG + + C + Sbjct: 188 RMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYV 247 Query: 181 LVDSVASLGGTPLYMDRQGIDILYSGSQKALN 212 D ++G LY+ G+D S K LN Sbjct: 248 GFDLAHAVGNVELYLHDWGVDFACWCSYKYLN 279 >3DYD-A nrPDB Length = 427 Score = 36.6 bits (83), Expect = 0.019, Method: Composition-based stats. Identities = 28/183 (15%), Positives = 54/183 (29%), Gaps = 17/183 (9%) Query: 29 GPSNLPPRIMAAGGLQMIGSM------SKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSG 82 G P + A + S +EI ++++ Sbjct: 68 GNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYHCPEAPLEAKDVILTSGC 127 Query: 83 HCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEG 142 A++ L + PG + LV G + + E +G V P + + + Sbjct: 128 SQAIDLCLAVLANPGQNILVPRPG-FS-LYKTLAESMGIEVKLYNLLPEKSWEIDLKQLE 185 Query: 143 LAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGIDI 202 + + + S P H K L +VA+ P+ D D+ Sbjct: 186 YLIDEKTACLIVNNPS-----NPCGSVFSKRHLQKIL----AVAARQCVPILADEIYGDM 236 Query: 203 LYS 205 ++S Sbjct: 237 VFS 239 >6EEQ-A nrPDB Length = 490 Score = 36.6 bits (83), Expect = 0.020, Method: Composition-based stats. Identities = 16/80 (20%), Positives = 32/80 (40%), Gaps = 8/80 (10%) Query: 136 LQEVEEGLAQH-----KPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSV--ASL 188 ++ + + P + T G ++ GV+ P+ G++ + L VD S Sbjct: 230 PNDLRDAIRSDLEAGLVPFYVCGTIGTTALGVVDPIKELGKVAREFDLWLHVDGAYGGSA 289 Query: 189 GGTPLYMDRQ-GIDILYSGS 207 P + G+D++ S S Sbjct: 290 CICPEFQHYLDGVDLVDSIS 309 >4FL0-A nrPDB Length = 456 Score = 36.6 bits (83), Expect = 0.020, Method: Composition-based stats. Identities = 44/301 (14%), Positives = 100/301 (33%), Gaps = 43/301 (14%) Query: 97 GDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHG 156 S ++G G + + ++ V M P + + ++F Sbjct: 171 DSSVIIGQTGHF----HEKTKKY-QNVVYMPCGPNNSFFPDLAMT----PRTDVIFFCSP 221 Query: 157 ESSTGVLQPLDGFGELC---HRYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNA 213 + TG + +L +++ DS +++ GS +++ Sbjct: 222 NNPTGYVASRKQLHQLVDFAKTNGSIIIFDS-----AYAAFIED--------GSPRSIYE 268 Query: 214 PPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHH--TIPVISLYS 271 PG ++ + K + + I + +H T + Sbjct: 269 IPGAREVAIEVSSFSKFAGFTGVRLGWSI-IPDELLYSNGFPIINDFHRIVTTSFNGASN 327 Query: 272 LRES--LALIAEQGLEN---SWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAV 326 + ++ LA ++ GL+ ++E L L +LGL+++ A P + Sbjct: 328 IAQAGGLACLSSGGLKEIRSVNNYYKENRKILMDTLVSLGLKVYGGVNA---PYLWVHF- 383 Query: 327 PAGYDWRDIVSYVIDHFDI--EIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRAAL 384 G D+ + ++++ I G GP + LRI G R+++ ++ L+ Sbjct: 384 -KGSKSWDVFNEILENTHIITVPGSGFGPGGEEYLRISGFG---RRDHIVEASKRLQNFF 439 Query: 385 Q 385 Sbjct: 440 N 440 >3WY7-A nrPDB Length = 404 Score = 36.2 bits (82), Expect = 0.024, Method: Composition-based stats. Identities = 43/193 (22%), Positives = 68/193 (35%), Gaps = 21/193 (10%) Query: 5 KLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMA--------AGGLQMIGSMSKDMYQI 56 +L V PP A L+ + L L P L + A G + G+ ++ Sbjct: 49 ELRVRPPVAAELDLASNDYLGLSQHPDVLDGGVEALRTWGGGAGGSRLVTGNT-----EL 103 Query: 57 MDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIG 116 + + + + L SG+ A ALV + PG L+ ++ + VD Sbjct: 104 HEAFEHQLASFLGAESALVF---SSGYTANLGALVALSGPGS--LIVSDALSHASLVDAC 158 Query: 117 ERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRY 176 ARV P + + ++ S+ G L PL +C R+ Sbjct: 159 RLSRARVVV---SPHRDVDAVDAALAARTEERAVVVTESVFSADGDLAPLRDLHAVCRRH 215 Query: 177 KCLLLVDSVASLG 189 LLLVD LG Sbjct: 216 GALLLVDEAHGLG 228 >4PPM-A nrPDB Length = 861 Score = 36.2 bits (82), Expect = 0.026, Method: Composition-based stats. Identities = 40/191 (20%), Positives = 63/191 (32%), Gaps = 24/191 (12%) Query: 28 PGPS-NLPPRIMAAGGLQMIGSMS-KDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCA 85 P P N + A G I +S + + E+ + N + S SG A Sbjct: 451 PQPVVNALKNYLDAQGPNFIQYISIPEQTAKLAEVLCRL----APGNMGRVFFSNSGTEA 506 Query: 86 LEAAL----VNVLEPGDSFLVGAN-----GIWGQRAVDIGERI--GARVHPMTKDPGGHY 134 +EAA+ + +PG ++L + G D R + G Sbjct: 507 VEAAMKIAKASTGKPGIAYLRNSYHGKTLGALSITGRDKHRRYFTPLLDAMVEVPFG--- 563 Query: 135 TLQEVEEGLAQHKPVLLFLTHGESSTGVLQP----LDGFGELCHRYKCLLLVDSVASLGG 190 L + E L + L + + GV P L +LC LL+VD V + G Sbjct: 564 DLAALREALNREDVGALMIEPIQGEGGVHIPPAGYLQAVQQLCRETGVLLMVDEVQTGLG 623 Query: 191 TPLYMDRQGID 201 + D Sbjct: 624 RTGKLFACEWD 634 >5YKR-A nrPDB Length = 461 Score = 36.2 bits (82), Expect = 0.026, Method: Composition-based stats. Identities = 27/161 (16%), Positives = 54/161 (33%), Gaps = 18/161 (11%) Query: 90 LVNVLEPGDSFLVGANGIWG---------QRAVDIGERIGARV----HPMTKDPGGHYTL 136 L +L D +V G A + R G H T L Sbjct: 149 LCRMLSGRDKVVVFNCNYHGSVDESQVEFDAAGRMVPRAGVHPNGVRHATTTRLVEFNDL 208 Query: 137 QEVEEGLAQHKPVLLFLTHGESSTGVLQPLDG----FGELCHRYKCLLLVDSVASLGGTP 192 +E LA + ++ G++ P +G EL R+ L++D ++ P Sbjct: 209 DALEAALAHGDVAAVLTEPFMTNVGMVPPAEGFHAGLRELTRRHDVALIIDETHTISCGP 268 Query: 193 L-YMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYS 232 Y G++ + K + +++ S +++++ Sbjct: 269 AGYSGAHGLEPDFFVLGKCIAGGIPSAVWGCSQAQAERIWA 309 >3PDX-A nrPDB Length = 402 Score = 36.2 bits (82), Expect = 0.027, Method: Composition-based stats. Identities = 33/185 (17%), Positives = 56/185 (30%), Gaps = 21/185 (11%) Query: 29 GPSNLPPRIMAAGGLQMIGSMSKDM---YQIMDEIKEGIQYVFQTRNPLT---LVISGSG 82 G P + A + + +E Y PL ++++ Sbjct: 45 GNLPTDPEVTQAMKDALDSGKYNGYAPSIGYLSSREEVASYYHCPEAPLEAKDVILTSGC 104 Query: 83 HCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGH--YTLQEVE 140 A+E L + PG + L+ G R + E +G V P L+++E Sbjct: 105 SQAIELCLAVLANPGQNILIPRPGFSLYRT--LAESMGIEVKLYNLLPEKSWEIDLKQLE 162 Query: 141 EGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGI 200 + L S P H K L +VA P+ D Sbjct: 163 SLI---DEKTACLVVNNPS----NPCGSVFSKRHLQKIL----AVAERQCVPILADEIYG 211 Query: 201 DILYS 205 D+++S Sbjct: 212 DMVFS 216 >3MAF-B nrPDB Length = 518 Score = 35.1 bits (79), Expect = 0.052, Method: Composition-based stats. Identities = 40/259 (15%), Positives = 85/259 (32%), Gaps = 33/259 (12%) Query: 70 TRNPLTLVISGSGHC-ALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTK 128 T ++ A + P V A+ + + A G ++ P+ Sbjct: 170 TSGGTESLLLAMKTYRDWARATKGITAPEAVVPVSAHAAFDKAAQYFGIKL--VRTPLDA 227 Query: 129 DPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASL 188 D + + E + + V++ + GV+ P+ L + VD+ L Sbjct: 228 DY--RADVAAMREAITPN-TVVVAGSAPGYPHGVVDPIPEIAALAAEHGIGCHVDAC--L 282 Query: 189 GGT-------------PLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKT 235 GG P +G+ + + + K GTS+I + + ++ + Sbjct: 283 GGFILPWAERLGYPVPPFDFRLEGVTSVSADTHKYGYGAKGTSVILY--RRPDLLHYQYF 340 Query: 236 KPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAA 295 + + + F G ++SL E+G ++ R+ +AA Sbjct: 341 IAADWPGGLYFSPTFAGSRPGALSATAWAAMLSLG----------EEGYLDATRRILQAA 390 Query: 296 AYLHGRLQALGLQLFVKDP 314 L ++A+ + DP Sbjct: 391 DRLKAGVRAIPSLKILGDP 409 >1JS3-A nrPDB Length = 486 Score = 34.7 bits (78), Expect = 0.077, Method: Composition-based stats. Identities = 35/190 (18%), Positives = 54/190 (28%), Gaps = 42/190 (22%) Query: 34 PPRIMAAGGLQMIGSM------SKDMYQIMDEIKEGIQYVFQTRNPL--------TLVIS 79 P ++A IG + S ++ + + + + Q VI Sbjct: 86 YPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLQLPEAFLAGEAGEGGGVIQ 145 Query: 80 GSGHCALEAALVNVLEPGDSF-------------------LVGANGIWGQRAVDIGERIG 120 GS EA LV +L LV +V+ IG Sbjct: 146 GSAS---EATLVALLAARTKVVRRLQAASPGLTQGAVLEKLVAYASDQAHSSVERAGLIG 202 Query: 121 ARVHPMTKDPGGH-YTLQEVEEGLAQHK-----PVLLFLTHGESSTGVLQPLDGFGELCH 174 G ++E L + K P + T G +S L G +CH Sbjct: 203 GVKLKAIPSDGKFAMRASALQEALERDKAAGLIPFFVVATLGTTSCCSFDNLLEVGPICH 262 Query: 175 RYKCLLLVDS 184 L VD+ Sbjct: 263 EEDIWLHVDA 272 >3N0L-A nrPDB Length = 417 Score = 34.7 bits (78), Expect = 0.079, Method: Composition-based stats. Identities = 39/219 (17%), Positives = 75/219 (34%), Gaps = 26/219 (11%) Query: 35 PRIMAAGGLQMIGSMSK-----------DMY-QIMDEIKEGIQYVFQTRNPLTLVISGSG 82 P +M G + ++ + +I E + +F + V SG Sbjct: 39 PEVMEVMGSILTNKYAEGYPGKRYYGGCEFVDEIETLAIERCKKLFNCK--FANVQPNSG 96 Query: 83 HCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPG----GHYTLQE 138 A + ++ PGD L G + G + + + G G ++ Sbjct: 97 SQANQGVYAALINPGDKIL-GMDLSHGGHLTHGAKVSSSGKMYESCFYGVELDGRIDYEK 155 Query: 139 VEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQ 198 V E + KP L+ G S+ + F E+ L D +A + G + + Sbjct: 156 VREIAKKEKPKLI--VCGASAYARVIDFAKFREIADEIGAYLFAD-IAHIAGLVVAGEHP 212 Query: 199 G----IDILYSGSQKALNAPPGTSLISFSDKAKKKMYSR 233 ++ S + K L P G +++ ++ KK+ S Sbjct: 213 SPFPYAHVVSSTTHKTLRGPRGGIIMTNDEELAKKINSA 251 >2GB3-A nrPDB Length = 409 Score = 34.3 bits (77), Expect = 0.088, Method: Composition-based stats. Identities = 24/119 (20%), Positives = 49/119 (41%), Gaps = 5/119 (4%) Query: 72 NPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPG 131 P ++++ G A+ + + PGD LV + + G ++ P+T+ Sbjct: 101 KPENVLVTNGGSEAILFSFAVIANPGDEILVLE--PFYANYNAFAKIAGVKLIPVTRRME 158 Query: 132 GHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDG---FGELCHRYKCLLLVDSVAS 187 + + + E + + L++ + TGV+ D E+ R+ L+VD V S Sbjct: 159 EGFAIPQNLESFINERTKGIVLSNPCNPTGVVYGKDEMRYLVEIAERHGLFLIVDEVYS 217 Score = 30.4 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 12/66 (18%), Positives = 30/66 (45%), Gaps = 3/66 (4%) Query: 112 AVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGE 171 ++ ++ G R+H + T + E + ++KP +++ +H S G+ + + F Sbjct: 34 FAEMAKKRGVRIHHLNIGQPDLKTPEVFFERIYENKPEVVYYSH---SAGIWELREAFAS 90 Query: 172 LCHRYK 177 R + Sbjct: 91 YYKRRQ 96 >4IYO-A nrPDB Length = 397 Score = 33.9 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 26/176 (14%), Positives = 61/176 (34%), Gaps = 19/176 (10%) Query: 65 QYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVH 124 + V SG A + ++ +L+ G V + ++G + ER+ R Sbjct: 71 RCVAALEGGTRAFAFASGMAAT-STVMELLDAGSHV-VAMDDLYGGTF-RLFERVRRRTA 127 Query: 125 PMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTG---VLQPLDGFGELCHRYKCLLL 181 + + + + E+ T L + + ++ L + Sbjct: 128 GLDFSFVDLTDPAAFKAAIRADTK----MVWIETPTNPMLKLVDIAAIAVIARKHGLLTV 183 Query: 182 VDSV--ASLGGTPLYMDRQGIDILYSGSQKALNAPP----GTSLISFSDKAKKKMY 231 VD+ + + PL + G D++ + K LN G +++ + + ++M Sbjct: 184 VDNTFASPMLQRPLSL---GADLVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMA 236 >2X8U-A nrPDB Length = 412 Score = 33.9 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 43/341 (12%), Positives = 107/341 (31%), Gaps = 48/341 (14%) Query: 54 YQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAV 113 YQ ++ ++ + T + + + + + + GD ++ A+ Sbjct: 88 YQGHKACEDALKEFYGTEHAIVFSTGYQANLGM---ISTLAGKGDYIILDADSHASIYDG 144 Query: 114 DIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELC 173 + L + L L+ L S G + PL + Sbjct: 145 CWLG----DAEIVRFRHNSVEDLDKRLGRLPAEAGKLVVLEGVYSMMGDIAPLQEMVAVS 200 Query: 174 HRYKCLLLVDSVASLG-----GTPLYMD---RQGIDILYSGSQKALNAPPGTSLISFSDK 225 ++ ++LVD +G G ++ + +D + K++ G S+ Sbjct: 201 KKHGAMILVDEAHGMGFFGEHGRGVFEEAGVEADVDFVVGTFSKSVGTVGG---FCVSNH 257 Query: 226 AKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLE 285 K ++ +P+ F + P + + S+ + G + Sbjct: 258 PKFEVLRLVCRPYVFTASL--------------------PPSVVATAATSIRKLMHAGDK 297 Query: 286 NSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDI 345 + + + LH L+ +G +L + + V + + ++ + Sbjct: 298 RAHL--WKNSRRLHQGLRDMGYKLGTETAQS---AIIAVILTDMAQAVALWQGLL-EAGL 351 Query: 346 EIMGGLGPSTGK---VLRIGLLGCNATRENVDRVTEALRAA 383 + P+T +LR L ++ E V+++ +A Sbjct: 352 YVNTARPPATPAGMFLLRCSLCAEHS-DEQVEQILGMFESA 391 >5EAV-A nrPDB Length = 441 Score = 33.9 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 42/236 (17%), Positives = 74/236 (31%), Gaps = 31/236 (13%) Query: 33 LPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGI-QYVFQTRNPLTLVISGSGHCALEAALV 91 PR++AA Q ++ + +++ +++ + +++ +G A E+AL Sbjct: 87 CHPRVIAALCRQA-ERLTLTLRAFGNDVTGPACRFMAEMFGYDRVLLMNTGAEAGESALK 145 Query: 92 ---------NVLEPGD-SFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHY------T 135 + P ++ N WG+ + + Sbjct: 146 IARKWAYEVKEIPPDSAKVILCNNNYWGRTITACSSSTTFDCYNNFGPFTPGFELIDYDD 205 Query: 136 LQEVEEGLAQHKPVLLFLTHGESSTGVLQP----LDGFGELCHRYKCLLLVDSVASLGG- 190 + +EE L F+ + GV P L ELC LL+VD + + Sbjct: 206 VGALEEALKDPNVAAFFVEPIQGEGGVNVPKPGYLKRAHELCRSKNVLLIVDEIQTGLCR 265 Query: 191 ----TPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYL 242 D DIL G K+L+A G IS M K Sbjct: 266 TGRLLAADHDEVHPDILLLG--KSLSA--GVVPISAVMGRADVMDVLKPGTHGSTF 317 >1XI9-A nrPDB Length = 406 Score = 33.5 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 16/113 (14%), Positives = 43/113 (38%), Gaps = 8/113 (7%) Query: 78 ISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMT--KDPGGHYT 135 ++ + AL+ +L+PGD LV G + + G + ++ Sbjct: 106 VTAAVTEALQLIFGALLDPGDEILVP--GPSYPPYTGLVKFYGGKPVEYRTIEEEDWQPD 163 Query: 136 LQEVEEGLAQHKPVLLFLTHGESSTGVLQP---LDGFGELCHRYKCLLLVDSV 185 + ++ + + + + + + + TG L L+ + Y+ ++ D + Sbjct: 164 IDDIRKKI-TDRTKAIAVINPNNPTGALYDKKTLEEILNIAGEYEIPVISDEI 215 >4J8L-A nrPDB Length = 361 Score = 33.5 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 54/163 (33%), Gaps = 19/163 (11%) Query: 77 VISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTL 136 ++ G+G A+ A L +L+PG LV ++ V I E++G + + + L Sbjct: 70 LVQGAGTGAIRAGLAALLKPGQRLLVHDAPVYPTTRV-IIEQMGLTLITVDFN-----DL 123 Query: 137 QEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVD------SVASLGG 190 +++ + + +P + H L L D VA +G Sbjct: 124 SALKQVVDEQQPDAALVQHTRQQPQDSYVLADVLATLRAAGVPALTDDNYAVMKVARIGC 183 Query: 191 TPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSR 233 G ++ K P G + ++ + Sbjct: 184 ------ECGANVSTFSCFKLFG-PEGVGAVVGDADVINRIRAT 219 >1HC1-A nrPDB Length = 657 Score = 32.8 bits (73), Expect = 0.26, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 30/85 (35%), Gaps = 4/85 (4%) Query: 76 LVISGSGHCALEAALVNVLEPGDSFLVGANGI--WGQRAVDIG--ERIGARVHPMTKDPG 131 +++ S +E L + GD G NG +G G P+ Sbjct: 568 MLLPKSKPEGMEFNLYVAVTDGDKDTEGHNGGHDYGGTHAQCGVHGEAYPDNRPLGYPLE 627 Query: 132 GHYTLQEVEEGLAQHKPVLLFLTHG 156 + V +G++ K V++ + H Sbjct: 628 RRIPDERVIDGVSNIKHVVVKIVHH 652 >6EEM-B nrPDB Length = 512 Score = 32.8 bits (73), Expect = 0.29, Method: Composition-based stats. Identities = 12/82 (14%), Positives = 29/82 (35%), Gaps = 7/82 (8%) Query: 110 QRAVDIGERIGARVHPMTKDPGGHY--TLQEVEEGLAQH-----KPVLLFLTHGESSTGV 162 Q+A I V + ++ + ++ + P+ L T G +S+ Sbjct: 209 QKAAQIAGINPKNVRAIKTSKATNFGLSPNSLQSAILADIESGLVPLFLCATVGTTSSTA 268 Query: 163 LQPLDGFGELCHRYKCLLLVDS 184 + P+ + Y + +D+ Sbjct: 269 VDPIGPLCAVAKLYGIWVHIDA 290 >3X2F-A nrPDB Length = 411 Score = 32.0 bits (71), Expect = 0.41, Method: Composition-based stats. Identities = 18/75 (24%), Positives = 29/75 (38%), Gaps = 9/75 (12%) Query: 62 EGIQYVFQTRNPLTLVISGSGHCALEAALVN--VLEPGDSFLVGANGIWGQRAVDIGERI 119 ++Y+F N G+G +A + N +L G + +V G G+ + Sbjct: 167 SKMKYLFD--NRY-----GTGQSTWDAIMRNTNLLVAGKNVVVAGYGWCGRGIALRAAGL 219 Query: 120 GARVHPMTKDPGGHY 134 GARV DP Sbjct: 220 GARVIVTEVDPVKAV 234 >5LH9-A nrPDB Length = 458 Score = 31.6 bits (70), Expect = 0.55, Method: Composition-based stats. Identities = 65/377 (17%), Positives = 113/377 (29%), Gaps = 68/377 (18%) Query: 59 EIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVL-------EPG-DSFLVGANGIWGQ 110 ++ E + +F ++ S G A+E AL EPG FL NG G Sbjct: 101 DLAERLTGMFAQERMARVLFSSGGSDAVETALKMARQYWIASGEPGRTRFLSLRNGYHGV 160 Query: 111 RAVDIG-----------ERIGARVHPMTKDP-----GGHYTLQEVEEGLAQHKPVLLFLT 154 ++ A H + Q + + + L Sbjct: 161 HMGGTSVGGNGVYHYNHGQLLAGCHLLDTPWLYRNPWDCRDPQALTAHCIRQLEEQIALL 220 Query: 155 HGESSTGVL-QPLDGFG--------------ELCHRYKCLLLVD-SVASLG--GTPLYMD 196 ++ ++ +P+ G G E+C R+ LL+ D V G G L Sbjct: 221 GAQTIAALIAEPVQGAGGVIVPPADYWPRLREVCDRHGILLIADEVVTGFGRSGCMLGSR 280 Query: 197 RQGIDILYSGSQKALNA---PPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGC 253 G+ K + A P G +L F+ + + + + + + C Sbjct: 281 GWGVAPDILCLAKGITAGYIPLGATL--FNQRIADAIENGQGFSHMIMHGYTYSGHPTAC 338 Query: 254 DDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQL---F 310 + + + A + EQ L+ ++ + G ++ GL + Sbjct: 339 AAALAVLDIVEAEDLPGNAAKVGAQLLEQ-LQPLVERY-----AVVGEVRGKGLMIALDL 392 Query: 311 VKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATR 370 V D R P PA I + + P K+ I TR Sbjct: 393 VSDKRTRQP-----LDPAAGQPSRIADEA-RRAGVLVR----PIGNKI--ILSPPLTLTR 440 Query: 371 ENVDRVTEALRAALQHC 387 + + AL AA C Sbjct: 441 DEAGLMVSALEAAFARC 457 >4FNP-A nrPDB Length = 729 Score = 31.6 bits (70), Expect = 0.58, Method: Composition-based stats. Identities = 34/200 (17%), Positives = 71/200 (35%), Gaps = 31/200 (15%) Query: 25 LLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHC 84 LL PG S P ++ Q + MS+ +++ + F+ R L+ + Sbjct: 283 LLQPGESFQTPEVVMVYSDQGLNGMSQTYHELYRT--RLARGAFRDRERPILINNWEATY 340 Query: 85 --ALEAALVNV----LEPGDSFLVGANGIWGQR------AVDI----------GERIGAR 122 E +VN+ E G +V +G +G+R D + + + Sbjct: 341 FDFNEEKIVNIARTEAELGIELVVLDDGWFGERDDDRRSLGDWIVNRRKLPNGLDGLAKQ 400 Query: 123 VHPMTKDPGGHYTLQEV---EEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCL 179 V+ + G + V E +H L + + S G Q + + C Sbjct: 401 VNELGLQFGLWVEPEMVSPNSELYRKHPDWCLHVPNRPRSEGRNQLVLDYS---REDVCD 457 Query: 180 LLVDSVAS-LGGTPLYMDRQ 198 +++++++ L P+ + Sbjct: 458 YIIETISNVLASAPITYVKW 477 >2EEO-B nrPDB Length = 95 Score = 31.2 bits (69), Expect = 0.81, Method: Composition-based stats. Identities = 9/31 (29%), Positives = 19/31 (61%) Query: 80 GSGHCALEAALVNVLEPGDSFLVGANGIWGQ 110 GSG + A ++++PGD ++ A G++ + Sbjct: 40 GSGVIGINGAAAHLVKPGDLVILVAYGVFDE 70 >3CLR-D nrPDB Length = 321 Score = 30.8 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 16/78 (20%), Positives = 23/78 (29%), Gaps = 6/78 (7%) Query: 90 LVNVLEP--GDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEG----L 143 N L+ D +V G V G + K + E + Sbjct: 25 AANGLKKSGEDKVVVAVIGSQADAFVPALSVNGVDELVVVKGSSIDFDPDVFEASVSALI 84 Query: 144 AQHKPVLLFLTHGESSTG 161 A H P ++ L H S G Sbjct: 85 AAHNPSVVLLPHSVDSLG 102 >3CQ5-A nrPDB Length = 369 Score = 30.4 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 14/76 (18%), Positives = 30/76 (39%), Gaps = 3/76 (3%) Query: 120 GARVHPMTKDPGG--HYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYK 177 G + G + E + +P ++F+T + TG + LD + + Sbjct: 135 GTHTEFIAVSRGADFRIDMDVALEEIRAKQPDIVFVTTPNNPTGDVTSLDDVERIINVAP 194 Query: 178 CLLLVD-SVASLGGTP 192 +++VD + A +P Sbjct: 195 GIVIVDEAYAEFSPSP 210 >1AL3-A nrPDB Length = 324 Score = 30.1 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 22/154 (14%), Positives = 45/154 (29%), Gaps = 8/154 (5%) Query: 18 LSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSK-DMYQIMDEIKEGIQYVFQTRNP--- 73 + P L G ++ G + ++ + + VF + Sbjct: 171 VVTPEHPLATKGSVSIEELAQYPLVTYTFGFTGRSELDTAFNRAGLTPRIVFTATDADVI 230 Query: 74 LTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGH 133 T V G G + + V+ + D + ANGI+ IG R + D Sbjct: 231 KTYVRLGLGVGVIASMAVDPVSDPDLVKLDANGIFSHSTTKIGFRRSTFLRSYMYDFIQR 290 Query: 134 YTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLD 167 + + + + L E + + + Sbjct: 291 FAPHLTRDVV----DTAVALRSNEDIEAMFKDIK 320 >4DG5-A nrPDB Length = 403 Score = 30.1 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 13/94 (13%), Positives = 29/94 (30%), Gaps = 2/94 (2%) Query: 72 NPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPG 131 + + + + LEAA+ ++ L+ N + + + G Sbjct: 93 DKEVVFVPETRGEKLEAAIKDL--KEGDVLLVENTRYEDLDGKKESKNDPELGKYWASLG 150 Query: 132 GHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQP 165 + +H + TH E++ G L Sbjct: 151 DVFVNDAFGTAHREHASNVGISTHLETAAGFLMD 184 >4BQ0-A nrPDB Length = 448 Score = 29.7 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 54/267 (20%), Positives = 88/267 (32%), Gaps = 33/267 (12%) Query: 131 GGHYTLQEVEEGLAQHKPVLLFLTHGES---STGVLQP----LDGFGELCHRYKCLLLVD 183 GG E+ + + H + E S GVL P L E+C ++ LL+ D Sbjct: 200 GGVELANELLKLIELHDASNIAAVIVEPMSGSAGVLVPPVGYLQRLREICDQHNILLIFD 259 Query: 184 SV-ASLGGTPLY--MDRQGI--DILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPF 238 V + G Y + G+ D++ Q A P + S + ++ Sbjct: 260 EVITAFGRLGTYSGAEYFGVTPDLMNVAKQVTNGAVP-MGAVIASSEIYDTFMNQALPEH 318 Query: 239 SFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYL 298 + + + PV L +L ++A +N +Q E A + Sbjct: 319 A-------------VEFSHGYTYSAHPVACAAGLA-ALDILAR---DNLVQQSAELAPHF 361 Query: 299 HGRLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKV 358 L GLQ +R + A D V + G G Sbjct: 362 EKGLH--GLQGAKNVIDIRNCGLAGAIQIAPRDGDPTVRPFEAGMKLWQQGFYVRFGGDT 419 Query: 359 LRIGLLGCNATRENVDRVTEALRAALQ 385 L+ G NA E +DR+ +A+ AL Sbjct: 420 LQFGPT-FNARPEELDRLFDAVGEALN 445 >1B4N-A nrPDB Length = 619 Score = 29.7 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 26/126 (20%), Positives = 46/126 (36%), Gaps = 19/126 (15%) Query: 16 KPLSIPNQLLLGPGPSNLPPR-----IMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQT 70 +PLS N+L+ GP N P ++ A + G M + + Sbjct: 50 EPLSPENKLIFAAGPFNGLPTPSGGKLVVAAKSPLTGGYGDGNLGTMASVH------LRR 103 Query: 71 RNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAV----DIGERIGARVHPM 126 LV+ G + + +E + ++ A G+WG+ ++ E G V + Sbjct: 104 AGYDALVVEGKA----KKPVYIYIEDDNVSILSAEGLWGKTTFETERELKEIHGKNVGVL 159 Query: 127 TKDPGG 132 T P G Sbjct: 160 TIGPAG 165 >3GD5-A nrPDB Length = 323 Score = 29.7 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 13/70 (18%), Positives = 21/70 (30%), Gaps = 10/70 (14%) Query: 63 GIQYVFQTRNPLTLVISGSGHCALEAALVN--VLEPGDSFLVGANGIWGQRAVDIGERIG 120 + YV N ++ G + A+ P + RA +I R G Sbjct: 159 KLAYVGDGNNVAHSLLLGCAKVGMSIAVATPEGFTPDPAV--------SARASEIAGRTG 210 Query: 121 ARVHPMTKDP 130 A V + Sbjct: 211 AEVQILRDPF 220 >2C2Q-A nrPDB Length = 199 Score = 28.5 bits (62), Expect = 4.6, Method: Composition-based stats. Identities = 8/47 (17%), Positives = 19/47 (40%), Gaps = 3/47 (6%) Query: 108 WGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLT 154 +G D+ +R + PG + E+ + ++P ++ T Sbjct: 78 YGLGLTDVAKRHSGVAAAL---PGEAWRPDELRRKVEHYRPRIVAFT 121 >6GFF-I nrPDB Length = 618 Score = 28.5 bits (62), Expect = 4.9, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 17/49 (34%) Query: 66 YVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVD 114 V RN ++ GS LE +L + G+ NG + Sbjct: 520 EVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQ 568 >4MHX-A nrPDB Length = 510 Score = 28.5 bits (62), Expect = 5.2, Method: Composition-based stats. Identities = 12/63 (19%), Positives = 25/63 (39%), Gaps = 2/63 (3%) Query: 231 YSRKTKPFSFYLDIKWLA--NFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSW 288 + +P +Y D++ W D+ R H T + + + L ++ +Q + W Sbjct: 414 RTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQW 473 Query: 289 RQH 291 H Sbjct: 474 ETH 476 >2V7B-A nrPDB Length = 529 Score = 28.1 bits (61), Expect = 5.9, Method: Composition-based stats. Identities = 26/151 (17%), Positives = 43/151 (28%), Gaps = 13/151 (8%) Query: 217 TSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESL 276 + +S + K + Y + A + + + Y L L Sbjct: 185 IAFWLYSSGSTGKPKGTVHTHANLYWTAELYAKPILGIAENDVVFSAAKLFFAYGLGNGL 244 Query: 277 ALIAEQGLENSWRQHREAAAYLHGRLQALGLQLFVKDPALRLPTVTTVAVPAGYD----- 331 G R A + RL +F P L + + +PA D Sbjct: 245 TFPLSVGATAILMAERPTADAIFARLVEHRPTVFYGVPTLYANMLVSPNLPARADVAIRI 304 Query: 332 --------WRDIVSYVIDHFDIEIMGGLGPS 354 R+I HF EI+ G+G + Sbjct: 305 CTSAGEALPREIGERFTAHFGCEILDGIGST 335 >3SI2-A nrPDB Length = 327 Score = 28.1 bits (61), Expect = 6.0, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 24/62 (38%), Gaps = 4/62 (6%) Query: 212 NAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYS 271 +A P ++ + KK++S K D+ F D +HH P SLY Sbjct: 126 SAVPCAMMLELARALDKKLHSLKDVS-GSKPDLSLQLIF---FDGEEAFHHWSPQDSLYG 181 Query: 272 LR 273 R Sbjct: 182 SR 183 >2X4L-A nrPDB Length = 325 Score = 28.1 bits (61), Expect = 6.9, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 24/63 (38%), Gaps = 1/63 (1%) Query: 88 AALVNVLEPGDSFLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHK 147 A VN +EP + G + + + ++ A V M D ++ EG + Sbjct: 227 ALGVNFVEPSEDAKKATGGWFESLSWENVDKYPADVIIMD-DRASTIQPADITEGTWKQL 285 Query: 148 PVL 150 P + Sbjct: 286 PAV 288 >4ZM4-A nrPDB Length = 447 Score = 28.1 bits (61), Expect = 7.3, Method: Composition-based stats. Identities = 37/232 (15%), Positives = 68/232 (29%), Gaps = 50/232 (21%) Query: 24 LLLGPGP---SNLPPRIMAAGGLQMI-GSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVIS 79 L +G GP ++ A Q G M+ +++ I + + + Sbjct: 63 LNMGYGPHLFGYADREVLDAVADQFAKGHMTGLPHELDARAGALIAEL--VPGVEQVRFA 120 Query: 80 GSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG------------------- 120 SG A+ +AL LV + R G Sbjct: 121 NSGTEAVASALRLARATTGRTLVVTFEGHYHGWSETVLRAGKTALHMEGTRPTDVVPGAL 180 Query: 121 -----ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLT--HGESSTGVLQPLDGFGELC 173 A H + + E A+ + + ++ GV+ P GF +L Sbjct: 181 GMIPEALAHTVQLGWN---DPDALRELFARDGDRIAAVIVEPVLANAGVIPPAPGFLQLL 237 Query: 174 H----RYKCLLLVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLIS 221 R +L+ D V + G + G+Q+ P +++S Sbjct: 238 RELTGRSGAMLVFDEVIT-----------GFRVARGGAQERYGVEPDLTVLS 278 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.131 0.326 Lambda K H 0.267 0.0403 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,943,403 Number of Sequences: 36641 Number of extensions: 524782 Number of successful extensions: 1821 Number of sequences better than 10.0: 117 Number of HSP's better than 10.0 without gapping: 92 Number of HSP's successfully gapped in prelim test: 75 Number of HSP's that attempted gapping in prelim test: 1625 Number of HSP's gapped (non-prelim): 172 length of query: 392 length of database: 10,336,785 effective HSP length: 99 effective length of query: 293 effective length of database: 6,709,326 effective search space: 1965832518 effective search space used: 1965832518 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 60 (27.7 bits)