BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P21396 (526 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1O5W-A nrPDB 1085 0.0 2BXR-A nrPDB 975 0.0 2BK5-A nrPDB 783 0.0 3RHA-A nrPDB 189 3e-48 6CR0-A nrPDB 102 4e-22 3NK2-X nrPDB 97 2e-20 3KVE-A nrPDB 83 4e-16 2VVL-G nrPDB 81 1e-15 1REO-A nrPDB 73 3e-13 4FWE-A nrPDB 71 1e-12 3L1R-A nrPDB 70 2e-12 5L3D-A nrPDB 58 8e-09 3ABT-A nrPDB 58 8e-09 1F8S-A nrPDB 52 5e-07 3BI4-A nrPDB 51 1e-06 1SEZ-A nrPDB 45 7e-05 4IV9-A nrPDB 42 6e-04 5MOG-A nrPDB 41 0.001 4IVM-B nrPDB 40 0.002 2JB2-A nrPDB 40 0.003 5NMX-A nrPDB 39 0.008 1I8T-A nrPDB 38 0.010 3X0V-A nrPDB 38 0.010 4DGK-A nrPDB 38 0.014 3KYB-A nrPDB 37 0.018 3LOV-A nrPDB 36 0.046 4MO2-B nrPDB 35 0.067 3KKJ-A nrPDB 35 0.091 3I6D-A nrPDB 35 0.095 2IVE-A nrPDB 35 0.10 4ZCC-A nrPDB 34 0.12 5TWC-A nrPDB 33 0.23 3LXD-A nrPDB 33 0.25 4RPJ-A nrPDB 33 0.37 2CVJ-A nrPDB 33 0.40 1GPE-A nrPDB 32 0.63 6BRD-A nrPDB 32 0.69 5BR7-A nrPDB 31 1.1 4P5A-A nrPDB 31 1.1 3IHG-A nrPDB 31 1.2 3UP5-A nrPDB 31 1.3 3MJ4-A nrPDB 31 1.4 5ZYN-B nrPDB 31 1.5 2Q7V-A nrPDB 30 1.8 3WE0-A nrPDB 30 1.9 5EQD-A nrPDB 30 2.0 4ZN0-A nrPDB 30 2.1 6GAR-A nrPDB 30 2.2 3P1W-A nrPDB 30 2.3 3ATQ-A nrPDB 30 2.3 4AQG-A nrPDB 30 2.4 3F8P-A nrPDB 30 2.5 4C5O-A nrPDB 30 2.5 4A6N-B nrPDB 30 2.7 4Y4N-A nrPDB 30 3.2 4YNU-A nrPDB 30 3.3 3IBB-A nrPDB 30 3.6 3AB1-A nrPDB 29 3.9 4K22-A nrPDB 29 5.4 5DQP-A nrPDB 29 5.7 1FOH-A nrPDB 29 6.0 3LZX-A nrPDB 29 6.3 1V59-A nrPDB 28 7.1 1GAL-A nrPDB 28 7.4 3GDN-A nrPDB 28 8.5 2GAG-B nrPDB 28 9.0 2VOU-A nrPDB 28 9.1 3RED-A nrPDB 28 9.4 4OVI-A nrPDB 28 9.9 >1O5W-A nrPDB Length = 534 Score = 1085 bits (2805), Expect = 0.0, Method: Compositional matrix adjust. Identities = 523/526 (99%), Positives = 524/526 (99%) Query: 1 MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV 60 MTDLEKPNLAGHMFDV +IGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV Sbjct: 9 MTDLEKPNLAGHMFDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV 68 Query: 61 KWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA 120 KWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA Sbjct: 69 KWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA 128 Query: 121 YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNI 180 YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNI Sbjct: 129 YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNI 188 Query: 181 NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL 240 NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL Sbjct: 189 NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL 248 Query: 241 SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM 300 SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM Sbjct: 249 SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM 308 Query: 301 GAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADR 360 GAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADR Sbjct: 309 GAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADR 368 Query: 361 QAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG 420 AKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG Sbjct: 369 LAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG 428 Query: 421 RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKD 480 RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKD Sbjct: 429 RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKD 488 Query: 481 VPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC 526 VPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC Sbjct: 489 VPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC 534 >2BXR-A nrPDB Length = 527 Score = 975 bits (2520), Expect = 0.0, Method: Compositional matrix adjust. Identities = 459/525 (87%), Positives = 497/525 (94%) Query: 1 MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV 60 M + EK ++AGHMFDV +IGGGISGL+AAKLL+EY ++VLVLEARDRVGGRTYT+RNEHV Sbjct: 1 MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV 60 Query: 61 KWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA 120 +VDVGGAYVGPTQNRILRLSKELGIETYKVNV+ERLVQYVKGKTYPFRGAFPPVWNP+A Sbjct: 61 DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA 120 Query: 121 YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNI 180 YLDYNNLWRT+D MGKEIP DAPW+A+HA +WDKMTMK+LIDKICWTKTAR FAYLFVNI Sbjct: 121 YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI 180 Query: 181 NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL 240 NVTSEPHEVSALWFLWYV+QCGGT RIFSVTNGGQERKFVGGSGQVSE+IM LLGD+VKL Sbjct: 181 NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL 240 Query: 241 SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM 300 + PVT++DQ+ DNII+ETLNHEHYECKYVI+AIPP LTAKIHF+PELP ERNQLIQRLPM Sbjct: 241 NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM 300 Query: 301 GAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADR 360 GAVIKCM+YYKEAFWKKKDYCGCMIIEDE+API+ITLDDTKPDGSLPAIMGFILARKADR Sbjct: 301 GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR 360 Query: 361 QAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG 420 AKLHK+IRK+KICELYAKVLGSQEAL+PVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG Sbjct: 361 LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG 420 Query: 421 RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKD 480 RVIRQPVGRI+FAGTETAT+WSGYMEGAVEAGERAAREVLN LGKV +KDIWV+EPESKD Sbjct: 421 RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD 480 Query: 481 VPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLP 525 VPA+EITHTF ERNLPSV GLLKI G STSV L FVLYK K LP Sbjct: 481 VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLP 525 >2BK5-A nrPDB Length = 520 Score = 783 bits (2022), Expect = 0.0, Method: Compositional matrix adjust. Identities = 367/500 (73%), Positives = 432/500 (86%), Gaps = 2/500 (0%) Query: 23 ISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSK 82 ISG+AAAKLL + +NV+VLEARDRVGGRTYT+RN+ VK+VD+GG+YVGPTQNRILRL+K Sbjct: 14 ISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAK 73 Query: 83 ELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDA 142 ELG+ETYKVN ERL+ +VKGK+YPFRG FPPVWNP+ YLD+NN WRTMD+MG+EIP DA Sbjct: 74 ELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDA 133 Query: 143 PWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCG 202 PW+A A+EWD MTMK+L+DK+CWT++A++ A LFVN+ VT+E HEVSALWFLWYV+QCG Sbjct: 134 PWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCG 193 Query: 203 GTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHE 262 GT RIFS TNGGQERKFVGGSGQVSE+IM LLGD+VKL PV YIDQT +N++VETLNHE Sbjct: 194 GTTRIFSTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHE 253 Query: 263 HYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCG 322 YE KYVISAIPP L KIHF P LP RNQ+I R+P+G+VIKC+VYYKE FW+KKDYCG Sbjct: 254 MYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCG 313 Query: 323 CMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLG 382 MII+ EEAP+A TLDDTKP+G+ AIMGFILA KA + A+L K+ R +K+CELYAKVLG Sbjct: 314 TMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLG 373 Query: 383 SQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWS 442 S EAL PVHYEEKNWCEEQYSGGCYT YFPPGI+TQYGRV+RQPV RIYFAGTETAT WS Sbjct: 374 SLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWS 433 Query: 443 GYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLL 502 GYMEGAVEAGERAARE+L+A+GK+ + +IW EPES DVPA IT TFLER+LPSVPGLL Sbjct: 434 GYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLL 493 Query: 503 KITGVST--SVALLCFVLYK 520 ++ G++T S L F+ +K Sbjct: 494 RLIGLTTIFSATALGFLAHK 513 >3RHA-A nrPDB Length = 482 Score = 189 bits (479), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 136/450 (30%), Positives = 224/450 (49%), Gaps = 9/450 (2%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQ 74 DV ++G G SGL AA+ L + ++V VLEARDRVGGRT+T + +++GG +V P Q Sbjct: 9 DVVIVGAGPSGLTAARELKKAGLSVAVLEARDRVGGRTWTDTIDGAM-LEIGGQWVSPDQ 67 Query: 75 NRILRLSKELGIETY-KVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDE 133 ++ L ELG++ Y + E + GK + G PV N + + L +DE Sbjct: 68 TVLMELLDELGLKMYSRYRDGESVYIGADGKRTQYTGDTFPV-NETTKAEMDKLVAILDE 126 Query: 134 MGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEP-HEVSAL 192 + EI PW A+E D ++ + + + A LF+ + ++P H SAL Sbjct: 127 LAAEIGPTEPWAHPKARELDTISFHHWLRQNSNDEEACNNIGLFIAGGMLTKPAHAFSAL 186 Query: 193 WFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDD 252 + G + + + + +++ +GG QVS LGD V L+SPV I + D+ Sbjct: 187 QAVLMAASAGSFSHL-TDEDFILDKRVIGGMQQVSLLQAAELGDDVVLNSPVRTI-KWDE 244 Query: 253 NIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKE 312 N + ++VI A+PP L +++ F P LP ++Q+ Q +G VIK Y Sbjct: 245 NGVSVVSERATVNARFVIMAVPPNLYSRVSFDPPLPRRQHQMHQHQSLGLVIKVHAVYDT 304 Query: 313 AFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRK 372 FW+++ G A + D+T S ++GF+ KAD +L + RK+ Sbjct: 305 PFWREEGLSGTGF--SAGALVQEVYDNTNHGDSRGTLVGFVSDEKADAVFELSAEDRKKA 362 Query: 373 ICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYF 432 I E A LG + AL P Y E +W E+++ G Y + + G + +YG+ VG IY+ Sbjct: 363 ILESIAGFLGDK-ALTPEVYYESDWGSEEWTRGAYASSYDLGGLHRYGKDQHANVGPIYW 421 Query: 433 AGTETATQWSGYMEGAVEAGERAAREVLNA 462 + ++ A + +++GAV G+ A ++ A Sbjct: 422 SSSDLAAEGYQHVDGAVRMGQATAARIVEA 451 >6CR0-A nrPDB Length = 440 Score = 102 bits (254), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 106/472 (22%), Positives = 198/472 (41%), Gaps = 56/472 (11%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGP 72 ++D ++G G SGL AA+ LS +VL++EAR R+GGRT+ V N + V++GGA V Sbjct: 8 IYDAIVVGAGFSGLVAARELSAQGRSVLIIEARHRLGGRTHVV-NFLGRPVEIGGAGVHW 66 Query: 73 TQNRILRLSKELGI---ETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLD--YNNL 127 Q + + G E ++++ + + G+ + P A D Y Sbjct: 67 CQPHVFAEMQRYGFGFKEAPLADLDKAYMVFADGQK---------IDVPPATFDEEYTTA 117 Query: 128 WRTMDEMGKEI---PVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVT- 183 + +E+ P +P D ++ +D ++ + E +N +T Sbjct: 118 FEKFCSRSRELFPRPY-SPLDNHEVSNLDGVSARDHLESLGLN----ELQLASMNAELTL 172 Query: 184 ---SEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL 240 + E+S F+ + + + T+ + GG+ + + I + Sbjct: 173 YGGAPTTELSYPSFVKF--HALASWDTITFTDSEKRYHVQGGTNALCQAIFDDCRADSEF 230 Query: 241 SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM 300 PV + QTD+ + V + + + +P + A + F+P LPPE+ I+ M Sbjct: 231 GVPVEAVAQTDNGVTVTLADKRVFRALTCVLTLPTKVYADVRFEPPLPPEKRAFIEHAEM 290 Query: 301 GAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAI-----MGFILA 355 + V+ ++ +C DD P ++ +G IL Sbjct: 291 ADGAELYVHVRQNLGNTFTFC----------------DDPNPFNAVQTYAYDDELGTILK 334 Query: 356 RKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGI 415 RQ+ ++ + E+ K+ G E L + Y NW ++Y+ Y A G Sbjct: 335 ITIGRQSLINLENFDAIAAEI-RKIHGDVEVLEALPY---NWAMDEYARTSYPA-MRKGW 389 Query: 416 MTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVA 467 ++Y + + +P R++FAG+ TA W Y++GA+E+G R RE+ + + A Sbjct: 390 FSRY-KDMAKPENRLFFAGSATADGWHEYIDGAIESGIRVGREIRHFMKATA 440 >3NK2-X nrPDB Length = 431 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 122/478 (25%), Positives = 201/478 (42%), Gaps = 85/478 (17%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKW--VDVGGAYV 70 M+D ++GGG SGL AA+ L+ VL+LE +R+GGR Y+ + +V V++GGAY+ Sbjct: 1 MYDAIVVGGGFSGLKAARDLTNAGKKVLLLEGGERLGGRAYSRESRNVPGLRVEIGGAYL 60 Query: 71 GPTQNRILRLSKEL---GIETYK----VNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLD 123 + RL+ EL GI T + RL + +P G+ Y Sbjct: 61 HRKHHP--RLAAELDRYGIPTAAASEFTSFRHRLGPTAVDQAFPIPGSEAVAVEAATYTL 118 Query: 124 YNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVT 183 + R E G E + ++ D + + + +DK+ +R+F L N+ Sbjct: 119 LRDAHRIDLEKGLE--------NQDLEDLD-IPLNEYVDKLDLPPVSRQF-LLAWAWNML 168 Query: 184 SEP-HEVSALWFLWYVRQCGGTARIFSVTNG--GQERKFVGGSGQVSEQIMGLLGDKVKL 240 +P + SALW L V A +S+ + F GS + + + + +++L Sbjct: 169 GQPADQASALWMLQLV-----AAHHYSILGVVLSLDEVFSNGSADLVDAMSQEI-PEIRL 222 Query: 241 SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM 300 + VT IDQ+ D + V + ++ VI A P +I F P LP R +I+ Sbjct: 223 QTVVTGIDQSGDVVNVTVKDGHAFQAHSVIVATPMNTWRRIVFTPALPERRRSVIEEGHG 282 Query: 301 GAVIKCMVYYKEA-----------FWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAI 349 G +K +++ + A F DY C + E E +A T Sbjct: 283 GQGLKILIHVRGAEAGIECVGDGIFPTLYDY--CEVSESERLLVAFT------------- 327 Query: 350 MGFILARKADRQAKLHKDIRKRKICELY----AKVLGSQEALYPVHYEEKNWCEEQYSGG 405 D + DI K LY +VLG + +W + G Sbjct: 328 ---------DSGSFDPTDIGAVKDAVLYYLPEVEVLG---------IDYHDWIADPLFEG 369 Query: 406 CYTAYFPPGIMTQYGRV---IRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVL 460 + A P + Q+ RV + +P GRI+F G++ + ++ GY+EGA+E E A +L Sbjct: 370 PWVA---PRV-GQFSRVHKELGEPAGRIHFVGSDVSLEFPGYIEGALETAECAVNAIL 423 >3KVE-A nrPDB Length = 486 Score = 82.8 bits (203), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 113/482 (23%), Positives = 193/482 (40%), Gaps = 69/482 (14%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQN 75 V ++G G+SGL+AA +L+ V VLEA +R GGR T RN W G P ++ Sbjct: 36 VVVVGAGMSGLSAAYVLAGAGHKVTVLEASERAGGRVRTHRNSKEGWYANLGPMRIPEKH 95 Query: 76 RILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMG 135 RI+R I + +N+NE + N A+ N+ + + E+ Sbjct: 96 RIVREY----IRKFGLNLNEFSQE-----------------NDNAWYFIKNIRKRVGEVN 134 Query: 136 KE-----IPVDAPWQARHA----QEWDKMTMKDLIDKICW-------TKTAREFAYLFVN 179 K+ PV + + A +E +KDL C T + +E YL Sbjct: 135 KDPGLLKYPVKPSEEGKSAGQLYEESLGSAVKDLKRTNCSYILNKYDTYSTKE--YLIKE 192 Query: 180 INVTSEPHEVSALWFLWYVRQCGGTARIFSVTNG---GQERKF---VGGSGQVSEQIMGL 233 N++ P V + L + I S+ + E++F VGG Q+ + Sbjct: 193 GNLS--PGAVDMIGDLLNEDSGYYVSFIESLKHDDIFAYEKRFDEIVGGMDQLPTSMYRA 250 Query: 234 LGDKVKLSSPVTYIDQTDDNIIVETLNHE----HYECKYVISAIPPILTAKIHFKPELPP 289 + +KVK ++ V I Q + + V E YVI +I F+P LPP Sbjct: 251 IEEKVKFNARVIKIQQNANQVTVTYQTPEKDTSSNTADYVIVCTTSRAARRIQFEPPLPP 310 Query: 290 ERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAI 349 ++ ++ + + K + FW+ G D + P+ + Sbjct: 311 KKQHALRSVHYRSGTKIFLTCSSKFWEDDGIHGGKSTTDLPSRFIYY-----PNHNFSTG 365 Query: 350 MGFILARKADRQAKLHKDIRKRKICELYAKVLG---------SQEALYPVHYEEKNWCEE 400 +G I+A A + ++ + ++ L Q YP ++ W + Sbjct: 366 VGVIIAYGIGDDANFFQALKFKDCADIVFNDLSLIHQLPKEEIQSFCYPSMIQK--WSLD 423 Query: 401 QYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVL 460 +Y+ G T F P ++ + P GRI+FAG TA + G+++ +++G AAR+V Sbjct: 424 KYAMGAITT-FTPYQFQRFSEALTAPQGRIFFAGEYTA-EAHGWIDSTIKSGLTAARDVN 481 Query: 461 NA 462 A Sbjct: 482 RA 483 >2VVL-G nrPDB Length = 495 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 112/485 (23%), Positives = 200/485 (41%), Gaps = 49/485 (10%) Query: 2 TDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVK 61 T++E + G +DV +IGGG GL A + L+ L+LEARDR+GGR+++ + Sbjct: 29 TNIEDTDKDG-PWDVIVIGGGYCGLTATRDLTVAGFKTLLLEARDRIGGRSWSSNIDGYP 87 Query: 62 WVDVGGAYVGPTQNRILRLSKELGIETYKV-NVNERLVQYVKGKTYPFRGAFPPVWNPLA 120 + ++GG +V Q+ + R I YK+ N + +G + P + Sbjct: 88 Y-EMGGTWVHWHQSHVWRE-----ITRYKMHNALSPSFNFSRGVNHFQLRTNPTTSTYMT 141 Query: 121 YLDYNNLWRT-------MDEMGKEIPVDAPWQARHAQE---WDKMTMKDLIDKICWTKTA 170 + + L R+ +D + P + E +D+M+ + ID+I + Sbjct: 142 HEAEDELLRSALHKFTNVDGTNGRTVLPFPHDMFYVPEFRKYDEMSYSERIDQIRDELSL 201 Query: 171 REFAYL--FVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSE 228 E + L F+ + S FL + G T + + KF G + Sbjct: 202 NERSSLEAFILLCSGGTLENSSFGEFLHWWAMSGYTYQ--GCMDCLMSYKFKDGQSAFAR 259 Query: 229 QI------MGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIH 282 + G LG PV + D V + + K V+ IP + + I Sbjct: 260 RFWEEAAGTGRLG--YVFGCPVRSVVNERDAARVTARDGREFVAKRVVCTIPLNVLSTIQ 317 Query: 283 FKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKP 342 F P L ER I + G V C + E KD I + + D Sbjct: 318 FSPALSTER---ISAMQAGHVSMCTKVHAEV--DNKDMRSWTGIAYPFNKLCYAIGD--- 369 Query: 343 DGSLPAIMGFILARKAD-RQAKLHKDIRK--RKICELYAKVLGSQEALYPVHYEEKNWCE 399 G+ PA ++ D + +D+R+ + + +L G + ++ NW + Sbjct: 370 -GTTPAGNTHLVCFGTDANHIQPDEDVRETLKAVGQLAPGTFGVKRLVF------HNWVK 422 Query: 400 EQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREV 459 ++++ G + + PG++++ + +R+ G + FA ++ A W +++GA+E G RAAR V Sbjct: 423 DEFAKGAW-FFSRPGMVSECLQGLREKHGGVVFANSDWALGWRSFIDGAIEEGTRAARVV 481 Query: 460 LNALG 464 L LG Sbjct: 482 LEELG 486 >1REO-A nrPDB Length = 486 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 109/486 (22%), Positives = 201/486 (41%), Gaps = 77/486 (15%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQN 75 V ++G G+SGL+AA +LS V VLEA +R GGR T RN+ W G P ++ Sbjct: 36 VVVVGAGMSGLSAAYVLSGAGHQVTVLEASERAGGRVRTYRNDKEDWYANLGPMRLPEKH 95 Query: 76 RILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMG 135 R+ +E I + + +NE + N A+ N+ + + E+ Sbjct: 96 ---RIVREY-IRKFGLQLNEFSQE-----------------NDNAWYFIKNIRKRVGEVK 134 Query: 136 KE-----IPVDAPWQARHAQEWDKMTMKDLIDKICWTK---------TAREFAYLFVNIN 181 K+ PV + + A + + ++ +++++ T T YL N Sbjct: 135 KDPGVLKYPVKPSEEGKSAGQLYEESLGKVVEELKRTNCSYILNKYDTYSTKEYLLKEGN 194 Query: 182 VTSEPHEVSALWFL------WYVR--QCGGTARIFSVTNGGQERKF---VGGSGQVSEQI 230 ++ P V + L +YV + IF+ E++F VGG ++ + Sbjct: 195 LS--PGAVDMIGDLMNEDSGYYVSFPESLRHDDIFAY-----EKRFDEIVGGMDKLPTSM 247 Query: 231 MGLLGDKVKLSSPVTYIDQTDDNIIV--ETLNHE--HYECKYVISAIPPILTAKIHFKPE 286 + +KV L++ V I + + + V +T E YVI T +I F+P Sbjct: 248 YRAIEEKVHLNAQVIKIQKNAEKVTVVYQTPAKEMASVTADYVIVCTTSRATRRIKFEPP 307 Query: 287 LPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSL 346 LPP++ ++ + + K + + FW+ + G D + P+ + Sbjct: 308 LPPKKAHALRSVHYRSGTKIFLTCTKKFWEDEGIHGGKSTTDLPSRFIYY-----PNHNF 362 Query: 347 PAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEE----------KN 396 + +G I+A A + + + ++ V+ ++ + EE + Sbjct: 363 TSGVGVIIAYGIGDDANFFQALDFKDCADI---VINDLSLIHQLPREEIQTFCYPSMIQK 419 Query: 397 WCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAA 456 W ++Y+ G T F P + + V RIYFAG TA + G+++ +++G RAA Sbjct: 420 WSLDKYAMGGITT-FTPYQFQHFSESLTASVDRIYFAGEHTA-EAHGWIDSTIKSGLRAA 477 Query: 457 REVLNA 462 R+V A Sbjct: 478 RDVNRA 483 >4FWE-A nrPDB Length = 796 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 102/443 (23%), Positives = 167/443 (37%), Gaps = 35/443 (7%) Query: 30 KLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVG-GAYV--GPTQNRILRLSKELGI 86 + L + I V VLEA+DR+GGR + ++ K V VG GA + G N + + ++LGI Sbjct: 373 RQLHNFGIKVTVLEAKDRIGGRVWD--DKSFKGVTVGRGAQIVNGCINNPVALMCEQLGI 430 Query: 87 ETYKVNVNERLVQ---YVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAP 143 +K L+Q + T R F +N L LD + WR +++P+ Sbjct: 431 SMHKFGERCDLIQEGGRITDPTIDKRMDFH--FNAL--LDVVSEWRKDKTQLQDVPL--- 483 Query: 144 WQARHAQEWDKMTMKDL-IDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCG 202 +E K +K+ I +F + S H+VSA W + Sbjct: 484 --GEKIEEIYKAFIKESGIQFSELEGQVLQFHLSNLEYACGSNLHQVSAR--SWDHNE-- 537 Query: 203 GTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHE 262 F G G + E++ G ++L SPV ID + D + V T + Sbjct: 538 -----FFAQFAGDHTLLTPGYSVIIEKLAE--GLDIQLKSPVQCIDYSGDEVQVTTTDGT 590 Query: 263 HYECKYVISAIPPILTAK--IHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKK-- 318 Y + V+ +P L K I F P L ++ + I L G + K + + FW K Sbjct: 591 GYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQ 650 Query: 319 --DYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICEL 376 D+ G + + + D P +M I L ++ Sbjct: 651 GADFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMAT 710 Query: 377 YAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTE 436 ++ QE P Y W + + Y+ G Y + G ++FAG Sbjct: 711 LRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDIQGTVFFAGEA 770 Query: 437 TATQWSGYMEGAVEAGERAAREV 459 T + + GA +G R A ++ Sbjct: 771 TNRHFPQTVTGAYLSGVREASKI 793 >3L1R-A nrPDB Length = 478 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 109/485 (22%), Positives = 206/485 (42%), Gaps = 70/485 (14%) Query: 18 LIGGGISGLAAAKLLSEYKI-NVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYV----GP 72 ++G G+SG++AAK LSE I ++L+LEA D +GGR + + V++G +V G Sbjct: 9 VVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGIN-VELGANWVEGVNGG 67 Query: 73 TQNRILRL-SKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTM 131 N I + + L + ++ + + Y+ Y G V++ L ++ Sbjct: 68 KMNPIWPIVNSTLKLRNFRSDFD-----YLAQNVYKEDGG---VYDEDYVQKRIELADSV 119 Query: 132 DEMGKEIPVDAPWQARHAQEWDKMTMKDLIDK--------ICWTKTAREFAYLFVNI-NV 182 +EMG+++ A A + + M+ L + + +F Y F V Sbjct: 120 EEMGEKL--SATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPPRV 177 Query: 183 TSEPHEVSALWF------LWYV-RQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLG 235 TS + V F +++V Q G A ++ + GQ K SG++ + Sbjct: 178 TSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYL--AGQYLKTDDKSGKIVDP------ 229 Query: 236 DKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYV-ISAIPPILTAK-IHFKPELPPERNQ 293 +++L+ V I + + V+T ++ Y YV +SA +L + I FKP+LP + + Sbjct: 230 -RLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWKVR 288 Query: 294 LIQRLPMGAVIKCMVYYKEAFW-------------KKKDYCGCMIIEDEEAPIAITLDDT 340 I + M + + FW ++ Y G +++ P A L T Sbjct: 289 AIYQFDMAVYTMIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLLVT 348 Query: 341 KPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEE 400 D +R+ ++Q+ K +I ++ K+ ++ W + Sbjct: 349 VTDEE---------SRRIEQQSDEQT---KAEIMQVLRKMFPGKDVPDATDILVPRWWSD 396 Query: 401 QYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVL 460 ++ G ++ + P G+ +R PVGR+YF G T+ ++GY+ GA +G +A ++ Sbjct: 397 RFYKGTFSNW-PVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEILI 455 Query: 461 NALGK 465 N K Sbjct: 456 NCAQK 460 >5L3D-A nrPDB Length = 852 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 94/200 (47%), Gaps = 24/200 (12%) Query: 18 LIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYV-GPTQNR 76 +IG G+SGLAAA+ L + ++V +LEARDRVGGR T R + D+G V G N Sbjct: 283 IIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNY-VADLGAMVVTGLGGNP 341 Query: 77 ILRLSKELGIETYKVNVNERLVQYVKGKTYP------FRGAFPPVWNPLAY----LDYNN 126 + +SK++ +E K+ L + G+ P F + +Y LD+N Sbjct: 342 MAVVSKQVNMELAKIKQKCPLYE-ANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNV 400 Query: 127 LWRTMDEMGKEIPVDAPWQARHAQE-----WDKMT-----MKDLIDKICWTKTA-REFAY 175 L +G+ + V Q +H ++ W K+ +K+L++K+ K +E Sbjct: 401 LNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQ 460 Query: 176 LFVNINVTSEPHEVSALWFL 195 + + P +++A + + Sbjct: 461 QYKEASEVKPPRDITAEFLV 480 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 51/254 (20%), Positives = 94/254 (37%), Gaps = 34/254 (13%) Query: 235 GDKVKLSSPVTYIDQTDDNIIVETLNHEH------YECKYVISAIP-PILTAK---IHFK 284 G +KL++ V + T V +N Y+C V+ +P +L + + F Sbjct: 581 GLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFV 640 Query: 285 PELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKK----DYCGCMIIEDEEAPIAITLDDT 340 P LP + +QR+ G + K ++ + FW + G E + L Sbjct: 641 PPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKA 700 Query: 341 KPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEE 400 P ++ + A + D+ + + + GS P W + Sbjct: 701 ------PILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRAD 754 Query: 401 QYSGGCYTAYFPPG-------IMTQ---YGRVI---RQPVGRIYFAGTETATQWSGYMEG 447 ++ G ++ Y G +M Q G I QP+ R++FAG T + + G Sbjct: 755 PWARGSHS-YVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHG 813 Query: 448 AVEAGERAAREVLN 461 A+ +G R A + + Sbjct: 814 ALLSGLREAGRIAD 827 >3ABT-A nrPDB Length = 662 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 55/202 (27%), Positives = 95/202 (47%), Gaps = 24/202 (11%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYV-GPTQ 74 V +IG G+SGLAAA+ L + ++V +LEARDRVGGR T R + D+G V G Sbjct: 110 VIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNY-VADLGAMVVTGLGG 168 Query: 75 NRILRLSKELGIETYKVNVNERLVQYVKGKTYP------FRGAFPPVWNPLAY----LDY 124 N + +SK++ +E K+ L + G+ P F + +Y LD+ Sbjct: 169 NPMAVVSKQVNMELAKIKQKCPLYE-ANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDF 227 Query: 125 NNLWRTMDEMGKEIPVDAPWQARHAQE-----WDKMT-----MKDLIDKICWTKTA-REF 173 N L +G+ + V Q +H ++ W K+ +K+L++K+ K +E Sbjct: 228 NVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKEL 287 Query: 174 AYLFVNINVTSEPHEVSALWFL 195 + + P +++A + + Sbjct: 288 HQQYKEASEVKPPRDITAEFLV 309 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 47/253 (18%), Positives = 90/253 (35%), Gaps = 32/253 (12%) Query: 235 GDKVKLSSPVTYIDQTDDNIIVETLNHEH------YECKYVISAIP-PILTAK---IHFK 284 G +KL++ V + T V +N Y+C V+ +P +L + + F Sbjct: 410 GLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFV 469 Query: 285 PELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKK----DYCGCMIIEDEEAPIAITLDDT 340 P LP + +QR+ G + K ++ + FW + G E + L Sbjct: 470 PPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKA 529 Query: 341 KPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEE 400 P ++ + A + D+ + + + GS P W + Sbjct: 530 ------PILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRAD 583 Query: 401 QYSGGCYTAYFPPGIMTQYGRVIR------------QPVGRIYFAGTETATQWSGYMEGA 448 ++ G Y+ Y + + QP+ R++FAG T + + GA Sbjct: 584 PWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGA 643 Query: 449 VEAGERAAREVLN 461 + +G R A + + Sbjct: 644 LLSGLREAGRIAD 656 >1F8S-A nrPDB Length = 498 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 61/260 (23%), Positives = 103/260 (39%), Gaps = 25/260 (9%) Query: 216 ERKF---VGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIV--ETLNHE--HYECKY 268 E++F V G ++ + + DKV ++ V I Q D + V ETL+ E Y Sbjct: 230 EKRFDEIVDGMDKLPTAMYRDIQDKVHFNAQVIKIQQNDQKVTVVYETLSKETPSVTADY 289 Query: 269 VISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIED 328 VI I F P L P++ ++ + + K + FW+ G D Sbjct: 290 VIVCTTSRAVRLIKFNPPLLPKKAHALRSVHYRSGTKIFLTCTTKFWEDDGIHGGKSTTD 349 Query: 329 EEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGS----- 383 + P+ + +G I+A A + + + ++ L Sbjct: 350 LPSRFIYY-----PNHNFTNGVGVIIAYGIGDDANFFQALDFKDCADIVFNDLSLIHQLP 404 Query: 384 ----QEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETAT 439 Q YP ++ W ++Y+ G T F P + + GRIYFAG TA Sbjct: 405 KKDIQSFCYPSVIQK--WSLDKYAMGGITT-FTPYQFQHFSDPLTASQGRIYFAGEYTA- 460 Query: 440 QWSGYMEGAVEAGERAAREV 459 Q G+++ +++G RAAR+V Sbjct: 461 QAHGWIDSTIKSGLRAARDV 480 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 27/64 (42%), Positives = 38/64 (59%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQN 75 V ++G G++GL+AA +L+ V VLEA +R GGR T RNE W G P ++ Sbjct: 36 VVIVGAGMAGLSAAYVLAGAGHQVTVLEASERPGGRVRTYRNEEAGWYANLGPMRLPEKH 95 Query: 76 RILR 79 RI+R Sbjct: 96 RIVR 99 >3BI4-A nrPDB Length = 516 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 33/87 (37%), Positives = 50/87 (57%), Gaps = 7/87 (8%) Query: 16 VGLIGGGISGLAAAKLLSEYKI-NVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQ 74 V +IG GI+GL AA L + I + LVLEARDRVGGR TV + D+G ++ T Sbjct: 11 VIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGRKYDIGASWHHDT- 69 Query: 75 NRILRLSKELGIETYKVNVNERLVQYV 101 L+ L +E ++++N+ ++V Sbjct: 70 -----LTNPLFLEEAQLSLNDGRTRFV 91 Score = 37.0 bits (84), Expect = 0.022, Method: Compositional matrix adjust. Identities = 25/71 (35%), Positives = 32/71 (45%), Gaps = 5/71 (7%) Query: 396 NWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVG---RIYFAGTETATQWSGYMEGAVEAG 452 NW + YS G Y+A FP V+ G RI FAG T +G GA E+G Sbjct: 439 NWTRDPYSRGAYSACFPGD--DPVDMVVAMSNGQDSRIRFAGEHTIMDGAGCAYGAWESG 496 Query: 453 ERAAREVLNAL 463 R A + + L Sbjct: 497 RREATRISDLL 507 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 23/93 (24%), Positives = 37/93 (39%), Gaps = 12/93 (12%) Query: 238 VKLSSPVTYIDQT-DDNIIVETLNHEHYECKYVISAIPPI-----------LTAKIHFKP 285 +KLS V I + N+ V + Y YVI +P L +I F+P Sbjct: 217 LKLSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVPQSVLNLSVQPEKNLRGRIEFQP 276 Query: 286 ELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKK 318 L P ++ GA+ K + ++E W + Sbjct: 277 PLKPVIQDAFDKIHFGALGKVIFEFEECCWSNE 309 >1SEZ-A nrPDB Length = 504 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 27/86 (31%), Positives = 47/86 (54%), Gaps = 4/86 (4%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQN 75 V +IG G+SGLAAA L + +NV V EA + GG+ +V + + W D G + ++ Sbjct: 16 VAVIGAGVSGLAAAYKLKIHGLNVTVFEAEGKAGGKLRSVSQDGLIW-DEGANTMTESEG 74 Query: 76 RILRLSKELGI---ETYKVNVNERLV 98 + L LG+ + + ++ N+R + Sbjct: 75 DVTFLIDSLGLREKQQFPLSQNKRYI 100 >4IV9-A nrPDB Length = 557 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 29/98 (29%), Positives = 50/98 (51%), Gaps = 7/98 (7%) Query: 16 VGLIGGGISGL-AAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVK---WVDVGGAYVG 71 V ++G GISGL AA +LL +V++ E+RDR+GGR ++ + + ++G Sbjct: 41 VAIVGAGISGLVAATELLRAGVKDVVLYESRDRIGGRVWSQVFDQTRPRYIAEMGAMRFP 100 Query: 72 PTQNRILRLSKELGIETYKVNVNERLVQ---YVKGKTY 106 P+ + K+ GI T + +V + +GK Y Sbjct: 101 PSATGLFHYLKKFGISTSTTFPDPGVVDTELHYRGKRY 138 >5MOG-A nrPDB Length = 497 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 24/73 (32%), Positives = 37/73 (50%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPT 73 V + G G++GL+ AK L++ ++LEARD +GG+ ++E W + G Sbjct: 18 LQVVIAGAGLAGLSTAKYLADAGHKPILLEARDVLGGKIAAWKDEDGDWYETGLHIFFGA 77 Query: 74 QNRILRLSKELGI 86 I L ELGI Sbjct: 78 YPNIQNLFGELGI 90 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 14/48 (29%), Positives = 26/48 (54%) Query: 424 RQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDI 471 R P+ Y AG T ++ MEGAV +G+ A+ V+ ++++ + Sbjct: 433 RSPIEGFYLAGDYTKQKYLASMEGAVLSGKLCAQSVVEDYKMLSRRSL 480 >4IVM-B nrPDB Length = 483 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 46/175 (26%), Positives = 75/175 (42%), Gaps = 20/175 (11%) Query: 18 LIGGGISGLAAAKLLSEYKI--NVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPT-- 73 ++GGGISGLAA+ LS V+++E+ +R+GG +VR + ++G + P Sbjct: 13 VLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPGGIRPAGA 72 Query: 74 -QNRILRLSKELGIETYKVNVN------ERLVQYVKGKTYP----FRGAF---PPVWNPL 119 R L L ELG+++ + V + YV G + RG PP PL Sbjct: 73 LGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSKPL 132 Query: 120 AYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFA 174 + L + + E V + Q R E + M L + + +RE + Sbjct: 133 FWAGLRELTKPRGKEPDET-VHSFAQRRLGPEVASLAMDSLCRGV-FAGNSRELS 185 >2JB2-A nrPDB Length = 489 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 93/466 (19%), Positives = 171/466 (36%), Gaps = 73/466 (15%) Query: 18 LIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRN----------------EHVK 61 ++GGG +GL +A L + V VLEAR R GGR +T R Sbjct: 16 VLGGGPAGLCSAFELQKAGYKVTVLEARTRPGGRVWTARGGSEETDLSGETQKCTFSEGH 75 Query: 62 WVDVGGAYVGPTQNRILRLSKELGIE-------TYKVNVNERLVQYVKGKTYPFRGAFPP 114 + +VG + P + L +ELG+E VN + + G++ +R A Sbjct: 76 FYNVGATRI-PQSHITLDYCRELGVEIQGFGNQNANTFVNYQSDTSLSGQSVTYRAAKAD 134 Query: 115 VWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMT-----MKDLIDKICWTKT 169 + ++ L + K A Q ++ D ++ DL D + + Sbjct: 135 TFGYMSEL-----------LKKATDQGALDQVLSREDKDALSEFLSDFGDLSDDGRYLGS 183 Query: 170 AREFAY-----LFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKF----V 220 +R Y +N +P + + +R G R FS G + V Sbjct: 184 SRR-GYDSEPGAGLNFGTEKKPFAMQEV-----IRS--GIGRNFSFDFGYDQAMMMFTPV 235 Query: 221 GGSGQVSEQIMGLLG-DKVKLSSPVTYIDQTDDNIIVETL---NHEHYECKYVISAIPPI 276 GG ++ +G D + + VT + + + VE + + Y I IPP Sbjct: 236 GGMDRIYYAFQDRIGTDNIVFGAEVTSMKNVSEGVTVEYTAGGSKKSITADYAICTIPPH 295 Query: 277 LTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKD--YCGCMIIEDEEAPIA 334 L ++ + LP + ++ + K + Y +W+ +D Y G + + + I Sbjct: 296 LVGRL--QNNLPGDVLTALKAAKPSSSGKLGIEYSRRWWETEDRIYGGASNTDKDISQIM 353 Query: 335 ITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEE 394 D D + R+ ++ H+ + I E +++ G + Sbjct: 354 FPYDHYNSDRGVVVAYYSSGKRQEAFESLTHRQRLAKAIAEG-SEIHGEKYTRDISSSFS 412 Query: 395 KNWCEEQYSGGCYTAYFPPGIMT------QYGRVIRQPVGRIYFAG 434 +W +YS + + G +Y +++ +PV +IYFAG Sbjct: 413 GSWRRTKYSESAWANWAGSGGSHGGAATPEYEKLL-EPVDKIYFAG 457 >5NMX-A nrPDB Length = 425 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 27/74 (36%), Positives = 36/74 (48%), Gaps = 5/74 (6%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGG--AYV 70 M V ++G G SGL AA+ L + V+V E VGG T+ +E W+ G Y Sbjct: 1 MRRVAVLGAGPSGLTAARYLKQAGFEVMVFERYHHVGG-TWNYTDE--TWMSEDGRPVYS 57 Query: 71 GPTQNRILRLSKEL 84 QN + L KEL Sbjct: 58 SMYQNLFVNLPKEL 71 >1I8T-A nrPDB Length = 367 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 36/66 (54%), Gaps = 1/66 (1%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGP 72 M+D ++G G+ G A L + VLV+E R+ +GG YT E ++ + GA++ Sbjct: 1 MYDYIIVGSGLFGAVCANELKKLNKKVLVIEKRNHIGGNAYTEDCEGIQ-IHKYGAHIFH 59 Query: 73 TQNRIL 78 T ++ + Sbjct: 60 TNDKYI 65 >3X0V-A nrPDB Length = 541 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 7/78 (8%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVL---VLEARDRVGGRTYTVRNEHVK--WVDVGGAYV 70 V ++G G+SGL A +L + KI L + E+ R GGR YT K + D+G Sbjct: 10 VCIVGAGVSGLYIAMILDDLKIPNLTYDIFESSSRTGGRLYTHHFTDAKHDYYDIGAMRY 69 Query: 71 G--PTQNRILRLSKELGI 86 P+ R L K G+ Sbjct: 70 PDIPSMKRTFNLFKRTGM 87 >4DGK-A nrPDB Length = 501 Score = 37.7 bits (86), Expect = 0.014, Method: Compositional matrix adjust. Identities = 19/41 (46%), Positives = 24/41 (58%) Query: 18 LIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNE 58 +IG G GLA A L I VL+LE RD+ GGR Y ++ Sbjct: 6 VIGAGFGGLALAIRLQAAGIPVLLLEQRDKPGGRAYVYEDQ 46 >3KYB-A nrPDB Length = 390 Score = 37.4 bits (85), Expect = 0.018, Method: Compositional matrix adjust. Identities = 18/62 (29%), Positives = 31/62 (50%), Gaps = 1/62 (1%) Query: 18 LIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVK-WVDVGGAYVGPTQNR 76 ++G G SG + L+E V +++ RD +GG +Y R+ V V G ++ T N Sbjct: 8 IVGAGFSGAVIGRQLAEKGHQVHIIDQRDHIGGNSYDARDSETNVMVHVYGPHIFHTDNE 67 Query: 77 IL 78 + Sbjct: 68 TV 69 >3LOV-A nrPDB Length = 475 Score = 35.8 bits (81), Expect = 0.046, Method: Compositional matrix adjust. Identities = 18/43 (41%), Positives = 28/43 (65%), Gaps = 2/43 (4%) Query: 18 LIGGGISGLAAAKLLSEY--KINVLVLEARDRVGGRTYTVRNE 58 ++GGGI+GLAAA +N+ +LEA +R+GG+ T R + Sbjct: 9 IVGGGITGLAAAYYAERAFPDLNITLLEAGERLGGKVATYRED 51 >4MO2-B nrPDB Length = 368 Score = 35.4 bits (80), Expect = 0.067, Method: Compositional matrix adjust. Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVG--GAYV 70 M+D ++G G+ G A +E LV+E R+ +GG YT E++K ++V GA++ Sbjct: 1 MYDYLIVGSGLFGSIFAYEATEKGYTCLVVEQREHIGGNCYT---ENIKNINVHKYGAHI 57 Query: 71 GPTQNR 76 T ++ Sbjct: 58 FRTSDQ 63 >3KKJ-A nrPDB Length = 336 Score = 35.0 bits (79), Expect = 0.091, Method: Compositional matrix adjust. Identities = 22/92 (23%), Positives = 40/92 (43%), Gaps = 1/92 (1%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQN 75 + +IG GI+GL+AA+ L+ V + + GGR + R++ +D+G Y Sbjct: 5 IAIIGTGIAGLSAAQALTAAGHQVHLFDKSRGSGGRMSSKRSD-AGALDMGAQYFTARDR 63 Query: 76 RILRLSKELGIETYKVNVNERLVQYVKGKTYP 107 R K+ + + L + G+ P Sbjct: 64 RFATAVKQWQAQGHVAEWTPLLYNFHAGRLSP 95 >3I6D-A nrPDB Length = 470 Score = 34.7 bits (78), Expect = 0.095, Method: Compositional matrix adjust. Identities = 27/83 (32%), Positives = 44/83 (53%), Gaps = 7/83 (8%) Query: 16 VGLIGGGISGLAAAKLLSE------YKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAY 69 V +IGGGI+GLAAA + + + + ++EA RVGG+ TV+ + ++ G Sbjct: 8 VVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASPRVGGKIQTVKKDGY-IIERGPDS 66 Query: 70 VGPTQNRILRLSKELGIETYKVN 92 + +L K+LG+E VN Sbjct: 67 FLERKKSAPQLVKDLGLEHLLVN 89 >2IVE-A nrPDB Length = 478 Score = 34.7 bits (78), Expect = 0.10, Method: Compositional matrix adjust. Identities = 17/41 (41%), Positives = 25/41 (60%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYT 54 +V ++GGGISGLA A L + ++LE+ R+GG T Sbjct: 17 MNVAVVGGGISGLAVAHHLRSRGTDAVLLESSARLGGAVGT 57 >4ZCC-A nrPDB Length = 336 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 22/92 (23%), Positives = 40/92 (43%), Gaps = 1/92 (1%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQN 75 + +IG GI+GL+AA+ L+ V + + GGR + R++ +D+G Y Sbjct: 5 IAIIGTGIAGLSAAQALTSAGHQVHLFDKSRGSGGRMSSKRSDAGS-LDMGAQYFTARDR 63 Query: 76 RILRLSKELGIETYKVNVNERLVQYVKGKTYP 107 R K+ + + L + G+ P Sbjct: 64 RFATAVKQWQAQGHVSEWTPLLYNFHGGRLSP 95 >5TWC-A nrPDB Length = 344 Score = 33.5 bits (75), Expect = 0.23, Method: Compositional matrix adjust. Identities = 30/97 (30%), Positives = 51/97 (52%), Gaps = 4/97 (4%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGP 72 M DV +IGGG SGL A+ ++V +++ + +GG+ + E + W D+GG P Sbjct: 1 MKDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKM-RIYPEKIIW-DIGGIAPKP 58 Query: 73 TQNRILRLSKELGIETY-KVNVNERLVQYVKGKTYPF 108 IL+ + + G+ +V++NER+V K F Sbjct: 59 CH-EILKDTIKQGLYFKPEVHLNERVVDIRKKAERHF 94 >3LXD-A nrPDB Length = 415 Score = 33.5 bits (75), Expect = 0.25, Method: Compositional matrix adjust. Identities = 17/35 (48%), Positives = 24/35 (68%) Query: 18 LIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRT 52 +IGGG GL AA +L+++ +NV +LEA RV R Sbjct: 157 VIGGGYIGLEAAAVLTKFGVNVTLLEALPRVLARV 191 >4RPJ-A nrPDB Length = 399 Score = 32.7 bits (73), Expect = 0.37, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 25/42 (59%), Gaps = 1/42 (2%) Query: 14 FDVGLIGGGISGLA-AAKLLSEYKINVLVLEARDRVGGRTYT 54 FD+ ++G G GL A ++ ++ VLVLE R +GG Y+ Sbjct: 8 FDLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGGNAYS 49 >2CVJ-A nrPDB Length = 180 Score = 32.7 bits (73), Expect = 0.40, Method: Compositional matrix adjust. Identities = 19/40 (47%), Positives = 27/40 (67%), Gaps = 5/40 (12%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRT 52 M+DV ++GGG SGL+AA L+ + VLVL+ GGR+ Sbjct: 1 MWDVIVVGGGPSGLSAALFLARAGLKVLVLD-----GGRS 35 >1GPE-A nrPDB Length = 587 Score = 32.0 bits (71), Expect = 0.63, Method: Compositional matrix adjust. Identities = 20/42 (47%), Positives = 27/42 (64%), Gaps = 2/42 (4%) Query: 4 LEKPN-LAGHMFDVGLIGGGISGLA-AAKLLSEYKINVLVLE 43 L P+ +AG +D + GGG++GL AAKL KI VLV+E Sbjct: 14 LSDPSKVAGKTYDYIIAGGGLTGLTVAAKLTENPKIKVLVIE 55 >6BRD-A nrPDB Length = 476 Score = 32.0 bits (71), Expect = 0.69, Method: Compositional matrix adjust. Identities = 20/53 (37%), Positives = 31/53 (58%), Gaps = 1/53 (1%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDV 65 MFDV ++GGG +GL A L + + VLVLE ++ R + HV+ ++V Sbjct: 1 MFDVIVVGGGPTGLMLAGELRLHGVRVLVLE-KETEPTRQSRAQGLHVRSIEV 52 >5BR7-A nrPDB Length = 393 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 25/42 (59%), Gaps = 1/42 (2%) Query: 14 FDVGLIGGGISGLAAA-KLLSEYKINVLVLEARDRVGGRTYT 54 FD+ ++G G+ GL A + S+ VL++E R +GG Y+ Sbjct: 4 FDLIVVGSGLFGLTVAERAASQLGKKVLIVEKRSHLGGNAYS 45 >4P5A-A nrPDB Length = 239 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 25/107 (23%), Positives = 45/107 (42%), Gaps = 7/107 (6%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVL-------VLEARDRVGGRTYTVRNEHVKWVDV 65 ++D G G I L ++ S ++ N + + R + RT++ E ++ +V Sbjct: 43 LYDGGSTRGLIRYLMRSRHGSPFEHNSMTFLVRAPIFTVRHLMRHRTWSFNEESARYREV 102 Query: 66 GGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAF 112 G A+ P R+LR + G Y + Q V+ T + AF Sbjct: 103 GAAFYVPDATRLLRQEGKPGDYRYVGGSTDDHQQVVRSATRAYEVAF 149 >3IHG-A nrPDB Length = 535 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 14/34 (41%), Positives = 21/34 (61%) Query: 12 HMFDVGLIGGGISGLAAAKLLSEYKINVLVLEAR 45 H DV ++G G+ GL+ A L+ + VLV+E R Sbjct: 4 HEVDVLVVGAGLGGLSTAMFLARQGVRVLVVERR 37 >3UP5-A nrPDB Length = 545 Score = 31.2 bits (69), Expect = 1.3, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 26/43 (60%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVR 56 D +IG G++G+ A L+++ + VL +EA + VGG Y R Sbjct: 10 LDAVVIGAGVTGIYQAFLINQAGMKVLGIEAGEDVGGTWYWNR 52 >3MJ4-A nrPDB Length = 397 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 22/40 (55%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTY 53 FD ++G G +G A+ L+ VL+++ R +GG Y Sbjct: 30 FDYLIVGAGFAGSVLAERLASSGQRVLIVDRRPHIGGNAY 69 >5ZYN-B nrPDB Length = 471 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 34/61 (55%), Gaps = 7/61 (11%) Query: 16 VGLIGGGISGLAAA-KLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQ 74 V +IG G++GL + +L+S+Y+I V++L+ +GG + + + GA+ Q Sbjct: 7 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASS------GINGAHTDTQQ 60 Query: 75 N 75 N Sbjct: 61 N 61 >2Q7V-A nrPDB Length = 325 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 21/32 (65%) Query: 12 HMFDVGLIGGGISGLAAAKLLSEYKINVLVLE 43 H +DV +IGGG +GL AA +++ L+LE Sbjct: 7 HDYDVVIIGGGPAGLTAAIYTGRAQLSTLILE 38 >3WE0-A nrPDB Length = 580 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 25/84 (29%), Positives = 41/84 (48%), Gaps = 9/84 (10%) Query: 10 AGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVD----- 64 A H +V ++G GI+GL AA L + + +V EA ++GGR +R++ D Sbjct: 62 ARHGEEVAIVGAGIAGLVAAYELMKLGLKPVVYEAS-KMGGR---LRSQAFNGTDGIIAE 117 Query: 65 VGGAYVGPTQNRILRLSKELGIET 88 +GG + +LG+ET Sbjct: 118 LGGMRFPVSSTAFYHYVDKLGLET 141 >5EQD-A nrPDB Length = 400 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 24/42 (57%), Gaps = 1/42 (2%) Query: 14 FDVGLIGGGISGLA-AAKLLSEYKINVLVLEARDRVGGRTYT 54 FD+ ++G G GL A + ++ VLV+E R +GG Y+ Sbjct: 5 FDLFVVGSGFFGLTIAERAATQLGKRVLVIERRPHIGGNAYS 46 >4ZN0-A nrPDB Length = 311 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 15/39 (38%), Positives = 25/39 (64%), Gaps = 1/39 (2%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGR 51 M+D+ +IGGG +GL A Y ++ L+LE R+ + G+ Sbjct: 7 MYDLIIIGGGPAGLTAGIYAVRYGLDTLILE-RNEISGQ 44 >6GAR-A nrPDB Length = 349 Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust. Identities = 20/55 (36%), Positives = 32/55 (58%), Gaps = 2/55 (3%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGG 67 +FDV +IGGG +GL +A ++ ++E +GG+ + V E + W DVGG Sbjct: 6 LFDVTVIGGGPAGLYSAFYSGLREMRTKIIEFHPHLGGKIH-VYPEKMIW-DVGG 58 >3P1W-A nrPDB Length = 475 Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 24/48 (50%) Query: 9 LAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVR 56 G +DV ++G G+ + LLS Y +LVL+ GG T ++ Sbjct: 16 FQGEHYDVIILGTGLKECILSGLLSHYGKKILVLDRNPYYGGETASLN 63 >3ATQ-A nrPDB Length = 453 Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust. Identities = 14/40 (35%), Positives = 28/40 (70%), Gaps = 2/40 (5%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEAR--DRVGGR 51 +DV +IGGG +G +AA LS + +L+++++ +R+G + Sbjct: 7 YDVLIIGGGFAGSSAAYQLSRRGLKILLVDSKPWNRIGDK 46 >4AQG-A nrPDB Length = 483 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 27/102 (26%), Positives = 43/102 (42%), Gaps = 15/102 (14%) Query: 382 GSQEALYPVHYEEKNWCEEQYSGGCYTAYFPP-GIMTQYGR--VIRQPVGRIYFAGTE-- 436 G + PV +E +WC E G A+ PP G + + GR + G A TE Sbjct: 186 GDENPRGPVSHEHVDWCREFVKGKYIMAFNPPWGDINKSGRSGIALVATGLAKLAETEGK 245 Query: 437 --------TATQWSGYMEGAVEAGERAARE--VLNALGKVAK 468 T +GY++ + +RA+ + + N L +AK Sbjct: 246 GIFDEAKKTVEALNGYLDKHKDEVDRASADSMITNLLKHIAK 287 >3F8P-A nrPDB Length = 323 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 14/31 (45%), Positives = 19/31 (61%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARD 46 V +IGGG S L A++LS Y V ++ RD Sbjct: 157 VAVIGGGDSALEGAEILSSYSTKVYLIHRRD 187 >4C5O-A nrPDB Length = 357 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 22/36 (61%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 DV +IGGG SGL+A L ++ ++L+A GG Sbjct: 5 DVVVIGGGQSGLSAGYFLRRSGLSYVILDAEASPGG 40 >4A6N-B nrPDB Length = 398 Score = 30.0 bits (66), Expect = 2.7, Method: Compositional matrix adjust. Identities = 16/39 (41%), Positives = 22/39 (56%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTY 53 +V +IGGG GL AKLL + I+V V E + R + Sbjct: 28 NVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIF 66 >4Y4N-A nrPDB Length = 286 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 14/29 (48%), Positives = 21/29 (72%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLE 43 DV ++GGG SGL AA+ +++ V+VLE Sbjct: 54 DVAIVGGGPSGLTAARYIAKEGYKVVVLE 82 >4YNU-A nrPDB Length = 571 Score = 29.6 bits (65), Expect = 3.3, Method: Compositional matrix adjust. Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 12/83 (14%) Query: 14 FDVGLIGGGISGLAAAKLLSEY-KINVLVLEAR-------DRVGGRTYTVR-NEHVKW-- 62 +D ++GGG SGL A LSE ++VL+LEA D Y + + W Sbjct: 6 YDYIVVGGGTSGLVVANRLSENPDVSVLLLEAGASVFNNPDVTNANGYGLAFGSAIDWQY 65 Query: 63 VDVGGAYVGPTQNRILRLSKELG 85 + +Y G Q ++LR K LG Sbjct: 66 QSINQSYAGGKQ-QVLRAGKALG 87 >3IBB-A nrPDB Length = 530 Score = 29.6 bits (65), Expect = 3.6, Method: Compositional matrix adjust. Identities = 18/49 (36%), Positives = 28/49 (57%), Gaps = 6/49 (12%) Query: 411 FPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREV 459 F P I+T +GRV +PVG + Q++G ++ + A E+AAR V Sbjct: 318 FAPNILTGFGRVEGRPVGIV----ANQPMQFAGCLD--ITASEKAARFV 360 >3AB1-A nrPDB Length = 360 Score = 29.3 bits (64), Expect = 3.9, Method: Compositional matrix adjust. Identities = 29/104 (27%), Positives = 49/104 (47%), Gaps = 4/104 (3%) Query: 1 MTDLEKPNLAGH-MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNE- 58 M D+ P H M D+ +IGGG +G+ AA I+ ++E+ ++GG+ + E Sbjct: 1 MLDIHNPATDHHDMRDLTIIGGGPTGIFAAFQCGMNNISCRIIESMPQLGGQLAALYPEK 60 Query: 59 HVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVK 102 H+ DV G P + + L + V +NE + +Y K Sbjct: 61 HI--YDVAGFPEVPAIDLVESLWAQAERYNPDVVLNETVTKYTK 102 >4K22-A nrPDB Length = 365 Score = 28.9 bits (63), Expect = 5.4, Method: Compositional matrix adjust. Identities = 15/31 (48%), Positives = 19/31 (61%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEAR 45 DV ++GGG+ GLA A L + V VLE R Sbjct: 5 DVAIVGGGMVGLAVACGLQGSGLRVAVLEQR 35 >5DQP-A nrPDB Length = 430 Score = 28.9 bits (63), Expect = 5.7, Method: Compositional matrix adjust. Identities = 13/30 (43%), Positives = 21/30 (70%) Query: 68 AYVGPTQNRILRLSKELGIETYKVNVNERL 97 A + P + RI LSK+LGI+ ++NV++ L Sbjct: 287 AGLDPAEQRIEALSKQLGIDLERINVDQVL 316 >1FOH-A nrPDB Length = 664 Score = 28.9 bits (63), Expect = 6.0, Method: Compositional matrix adjust. Identities = 12/21 (57%), Positives = 17/21 (80%) Query: 15 DVGLIGGGISGLAAAKLLSEY 35 DV ++G G +GL AA++LSEY Sbjct: 9 DVLIVGAGPAGLMAARVLSEY 29 >3LZX-A nrPDB Length = 332 Score = 28.9 bits (63), Expect = 6.3, Method: Compositional matrix adjust. Identities = 21/70 (30%), Positives = 34/70 (48%), Gaps = 4/70 (5%) Query: 1 MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV 60 + DL+K AG V ++GGG S + A +L V ++ RD+ ++V N H Sbjct: 146 VDDLQK--FAGRR--VAILGGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHA 201 Query: 61 KWVDVGGAYV 70 V+V +V Sbjct: 202 SKVNVLTPFV 211 >1V59-A nrPDB Length = 478 Score = 28.5 bits (62), Expect = 7.1, Method: Compositional matrix adjust. Identities = 15/41 (36%), Positives = 22/41 (53%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTV 55 DV +IGGG +G AA ++ N +E R ++GG V Sbjct: 7 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNV 47 >1GAL-A nrPDB Length = 583 Score = 28.5 bits (62), Expect = 7.4, Method: Compositional matrix adjust. Identities = 15/38 (39%), Positives = 25/38 (65%), Gaps = 1/38 (2%) Query: 8 NLAGHMFDVGLIGGGISGLAAAKLLSEY-KINVLVLEA 44 +++G D + GGG++GL A L+E I+VLV+E+ Sbjct: 14 DVSGRTVDYIIAGGGLTGLTTAARLTENPNISVLVIES 51 >3GDN-A nrPDB Length = 521 Score = 28.1 bits (61), Expect = 8.5, Method: Compositional matrix adjust. Identities = 22/42 (52%), Positives = 25/42 (59%), Gaps = 5/42 (11%) Query: 2 TDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLE 43 TDLE L G +D ++GGG SG A LSE K VLVLE Sbjct: 19 TDLE---LEGS-YDYVIVGGGTSGCPLAATLSE-KYKVLVLE 55 >2GAG-B nrPDB Length = 405 Score = 28.1 bits (61), Expect = 9.0, Method: Compositional matrix adjust. Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 5/61 (8%) Query: 14 FDVGLIGGGISGLAAAKLLSEYK--INVLVLEARDRVGG---RTYTVRNEHVKWVDVGGA 68 +D ++GGG GLA A L++ NV VLE GG R T+ + W + G Sbjct: 22 YDAIIVGGGGHGLATAYFLAKNHGITNVAVLEKGWLAGGNMARNTTIIRSNYLWDESAGI 81 Query: 69 Y 69 Y Sbjct: 82 Y 82 >2VOU-A nrPDB Length = 397 Score = 28.1 bits (61), Expect = 9.1, Method: Compositional matrix adjust. Identities = 27/119 (22%), Positives = 50/119 (42%), Gaps = 18/119 (15%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQN 75 + ++GG ISGL AA +L + ++V V E + G V Q Sbjct: 8 IAVVGGSISGLTAALMLRDAGVDVDVYERSPQ-------------PLSGFGTGIV--VQP 52 Query: 76 RILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEM 134 ++ E G+E ++V ++YV T G+ P W + Y++++ + E+ Sbjct: 53 ELVHYLLEQGVELDSISVPSSSMEYVDALTGERVGSVPADWR---FTSYDSIYGGLYEL 108 >3RED-A nrPDB Length = 521 Score = 28.1 bits (61), Expect = 9.4, Method: Compositional matrix adjust. Identities = 22/42 (52%), Positives = 25/42 (59%), Gaps = 5/42 (11%) Query: 2 TDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLE 43 TDLE L G +D ++GGG SG A LSE K VLVLE Sbjct: 19 TDLE---LEGS-YDYVIVGGGTSGCPLAATLSE-KYKVLVLE 55 >4OVI-A nrPDB Length = 542 Score = 28.1 bits (61), Expect = 9.9, Method: Compositional matrix adjust. Identities = 17/39 (43%), Positives = 21/39 (53%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTY 53 DV ++G G SGL A L E +V V+E VGG Y Sbjct: 18 DVLVVGAGFSGLYALYRLRELGRSVHVIETAGDVGGVWY 56 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1O5W-A nrPDB 788 0.0 2BXR-A nrPDB 759 0.0 2BK5-A nrPDB 679 0.0 3RHA-A nrPDB 421 e-118 3KVE-A nrPDB 399 e-111 1REO-A nrPDB 392 e-109 2VVL-G nrPDB 387 e-108 1F8S-A nrPDB 385 e-107 6CR0-A nrPDB 370 e-103 4FWE-A nrPDB 365 e-101 3L1R-A nrPDB 335 2e-92 3NK2-X nrPDB 319 3e-87 3ABT-A nrPDB 226 2e-59 5L3D-A nrPDB 222 3e-58 3BI4-A nrPDB 170 1e-42 4IV9-A nrPDB 148 5e-36 5MOG-A nrPDB 144 9e-35 1SEZ-A nrPDB 107 1e-23 Sequences not found previously or not previously below threshold: 2JB2-A nrPDB 150 2e-36 3X0V-A nrPDB 113 2e-25 3WE0-A nrPDB 112 4e-25 4IVM-B nrPDB 82 5e-16 3LOV-A nrPDB 79 3e-15 2IVE-A nrPDB 78 1e-14 3I6D-A nrPDB 74 2e-13 4DGK-A nrPDB 73 4e-13 1I8T-A nrPDB 63 2e-10 5ZBC-A nrPDB 61 9e-10 5BR7-A nrPDB 61 1e-09 4RPJ-A nrPDB 60 2e-09 5NMX-A nrPDB 59 3e-09 4MO2-B nrPDB 56 3e-08 5EQD-A nrPDB 56 4e-08 4ZCC-A nrPDB 56 5e-08 3KKJ-A nrPDB 55 1e-07 3KYB-A nrPDB 54 1e-07 2CVJ-A nrPDB 51 9e-07 3MJ4-A nrPDB 51 1e-06 3UKH-A nrPDB 51 2e-06 5Z70-A nrPDB 50 3e-06 4OVI-A nrPDB 49 3e-06 4REP-A nrPDB 49 4e-06 2YQU-A nrPDB 49 4e-06 3BHF-A nrPDB 49 5e-06 3K30-A nrPDB 49 6e-06 4Y4M-A nrPDB 48 1e-05 3LXD-A nrPDB 48 1e-05 1NAA-A nrPDB 46 3e-05 4Y4N-A nrPDB 46 3e-05 5MJK-A nrPDB 46 5e-05 3AB1-A nrPDB 46 6e-05 5VJ7-A nrPDB 45 6e-05 5JFC-L nrPDB 45 6e-05 3UP5-A nrPDB 45 9e-05 2UZZ-A nrPDB 45 1e-04 6JDK-A nrPDB 44 1e-04 3ATQ-A nrPDB 44 1e-04 4UIR-A nrPDB 44 1e-04 3URH-A nrPDB 44 1e-04 4YRY-B nrPDB 44 1e-04 4AP1-A nrPDB 44 1e-04 4C5O-A nrPDB 44 2e-04 2Q7V-A nrPDB 44 2e-04 3RP7-A nrPDB 44 2e-04 2VHY-A nrPDB 44 2e-04 2GAG-B nrPDB 43 3e-04 1V59-A nrPDB 43 3e-04 6BRD-A nrPDB 43 3e-04 1ZOV-A nrPDB 43 3e-04 3JSK-A nrPDB 43 4e-04 2VOU-A nrPDB 43 4e-04 3FPZ-A nrPDB 43 5e-04 1UKV-G nrPDB 42 6e-04 5TUF-A nrPDB 42 6e-04 3LZX-A nrPDB 42 7e-04 1DOD-A nrPDB 42 8e-04 3P1W-A nrPDB 41 9e-04 5TWC-A nrPDB 41 0.001 3IHG-A nrPDB 41 0.001 4GCM-A nrPDB 41 0.001 4K22-A nrPDB 41 0.001 4ZN0-A nrPDB 41 0.001 1RP0-A nrPDB 41 0.001 4C3X-A nrPDB 41 0.002 6N7F-A nrPDB 41 0.002 4A6N-B nrPDB 41 0.002 3R9U-A nrPDB 41 0.002 6C87-A nrPDB 40 0.002 5KOX-A nrPDB 40 0.002 5UTH-A nrPDB 40 0.002 2RGJ-A nrPDB 40 0.002 1NHQ-A nrPDB 40 0.003 5UWY-A nrPDB 40 0.003 3CP8-A nrPDB 40 0.003 1GPE-A nrPDB 39 0.004 2TMD-A nrPDB 39 0.004 5J5Z-A nrPDB 39 0.004 3CGD-A nrPDB 39 0.004 2A87-A nrPDB 39 0.005 3T14-A nrPDB 39 0.005 1EBD-A nrPDB 39 0.005 1PS9-A nrPDB 39 0.005 5YGQ-A nrPDB 39 0.005 6GAS-A nrPDB 39 0.006 4N9X-A nrPDB 39 0.006 5XGV-A nrPDB 39 0.007 2GMH-A nrPDB 39 0.007 5Y77-A nrPDB 38 0.009 2QA2-A nrPDB 38 0.009 6DLL-A nrPDB 38 0.009 4B1B-A nrPDB 38 0.010 5L46-A nrPDB 38 0.010 4P9S-A nrPDB 38 0.011 5XHU-A nrPDB 38 0.011 6J0Z-C nrPDB 38 0.011 4K2X-A nrPDB 38 0.012 2GV8-A nrPDB 38 0.013 6GAR-A nrPDB 37 0.013 5TR3-A nrPDB 37 0.017 1GAL-A nrPDB 37 0.019 4YNU-A nrPDB 37 0.020 4X4J-A nrPDB 37 0.022 5TUM-A nrPDB 37 0.022 3ISH-A nrPDB 37 0.023 4JDR-A nrPDB 37 0.028 5J7X-A nrPDB 36 0.029 6AON-A nrPDB 36 0.030 3O0H-A nrPDB 36 0.031 1FOH-A nrPDB 36 0.032 4MOP-A nrPDB 36 0.032 6C6P-A nrPDB 36 0.039 2EQ6-A nrPDB 36 0.041 3NIX-A nrPDB 36 0.042 4EMJ-A nrPDB 36 0.043 2E5V-A nrPDB 36 0.043 2R9Z-A nrPDB 36 0.046 4H7U-A nrPDB 36 0.053 3SM8-A nrPDB 36 0.062 4TXK-A nrPDB 35 0.064 2BRY-A nrPDB 35 0.064 4YKF-A nrPDB 35 0.076 3QJ4-A nrPDB 35 0.076 1FL2-A nrPDB 35 0.076 3COX-A nrPDB 35 0.092 3LAD-A nrPDB 35 0.097 4USR-A nrPDB 35 0.100 4RG3-A nrPDB 35 0.10 5TUK-A nrPDB 34 0.11 3GMC-A nrPDB 34 0.12 6ER9-A nrPDB 34 0.12 6BZ0-A nrPDB 34 0.14 6A37-A nrPDB 34 0.15 4HA6-A nrPDB 34 0.15 5EB4-A nrPDB 34 0.15 3IWA-A nrPDB 34 0.16 2CUL-A nrPDB 34 0.16 3FG2-P nrPDB 34 0.16 5OC1-A nrPDB 34 0.16 3L8K-A nrPDB 34 0.18 1DXL-A nrPDB 34 0.18 2EEZ-A nrPDB 34 0.19 3NTA-A nrPDB 34 0.20 1ZDL-A nrPDB 34 0.22 1KNR-A nrPDB 34 0.22 5U8W-A nrPDB 33 0.24 4NTC-A nrPDB 33 0.25 6CMZ-A nrPDB 33 0.25 1Y56-A nrPDB 33 0.27 1LVL-A nrPDB 33 0.27 5J72-A nrPDB 33 0.27 2BS2-A nrPDB 33 0.31 2X3N-A nrPDB 33 0.33 5EZ7-A nrPDB 33 0.33 5ZYN-B nrPDB 33 0.36 5KXJ-A nrPDB 33 0.37 3II4-A nrPDB 33 0.38 3RED-A nrPDB 32 0.42 3GDN-A nrPDB 32 0.42 4JNQ-A nrPDB 32 0.43 4CBQ-A nrPDB 32 0.45 3Q9T-A nrPDB 32 0.46 4P2C-A nrPDB 32 0.51 1C0L-A nrPDB 32 0.53 6BPY-A nrPDB 32 0.55 5X6R-A nrPDB 32 0.55 1YQZ-A nrPDB 32 0.61 4Z25-A nrPDB 32 0.74 5W4C-A nrPDB 32 0.77 2NVK-X nrPDB 32 0.81 5ER0-A nrPDB 32 0.85 4XDY-A nrPDB 31 0.94 2WOP-A nrPDB 31 1.00 5X68-A nrPDB 31 1.1 3IC9-A nrPDB 31 1.1 2YR5-A nrPDB 31 1.4 5X1Y-B nrPDB 31 1.5 3G5Q-A nrPDB 31 1.6 4MIF-A nrPDB 31 1.6 3IP1-A nrPDB 31 1.6 2XVH-A nrPDB 31 1.6 4Z2R-A nrPDB 31 2.0 4P5A-A nrPDB 30 2.2 3CUK-A nrPDB 30 2.3 1VE9-A nrPDB 30 2.3 5VT6-A nrPDB 30 2.4 6HRD-A nrPDB 30 3.0 2YVG-A nrPDB 30 3.1 5EVY-X nrPDB 30 3.4 4UDQ-A nrPDB 29 4.0 3GGO-A nrPDB 29 4.0 5I68-A nrPDB 29 4.3 1XLT-A nrPDB 29 4.6 3MOG-A nrPDB 29 5.3 3CP2-A nrPDB 29 6.2 3G05-A nrPDB 29 6.5 2QA1-A nrPDB 28 8.1 4TSK-A nrPDB 28 8.8 4BK3-A nrPDB 28 9.0 >1O5W-A nrPDB Length = 534 Score = 788 bits (2035), Expect = 0.0, Method: Composition-based stats. Identities = 523/526 (99%), Positives = 524/526 (99%) Query: 1 MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV 60 MTDLEKPNLAGHMFDV +IGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV Sbjct: 9 MTDLEKPNLAGHMFDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV 68 Query: 61 KWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA 120 KWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA Sbjct: 69 KWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA 128 Query: 121 YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNI 180 YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNI Sbjct: 129 YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNI 188 Query: 181 NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL 240 NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL Sbjct: 189 NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL 248 Query: 241 SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM 300 SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM Sbjct: 249 SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM 308 Query: 301 GAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADR 360 GAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADR Sbjct: 309 GAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADR 368 Query: 361 QAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG 420 AKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG Sbjct: 369 LAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG 428 Query: 421 RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKD 480 RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKD Sbjct: 429 RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKD 488 Query: 481 VPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC 526 VPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC Sbjct: 489 VPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC 534 >2BXR-A nrPDB Length = 527 Score = 759 bits (1959), Expect = 0.0, Method: Composition-based stats. Identities = 459/525 (87%), Positives = 497/525 (94%) Query: 1 MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV 60 M + EK ++AGHMFDV +IGGGISGL+AAKLL+EY ++VLVLEARDRVGGRTYT+RNEHV Sbjct: 1 MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHV 60 Query: 61 KWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA 120 +VDVGGAYVGPTQNRILRLSKELGIETYKVNV+ERLVQYVKGKTYPFRGAFPPVWNP+A Sbjct: 61 DYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIA 120 Query: 121 YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNI 180 YLDYNNLWRT+D MGKEIP DAPW+A+HA +WDKMTMK+LIDKICWTKTAR FAYLFVNI Sbjct: 121 YLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNI 180 Query: 181 NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL 240 NVTSEPHEVSALWFLWYV+QCGGT RIFSVTNGGQERKFVGGSGQVSE+IM LLGD+VKL Sbjct: 181 NVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKL 240 Query: 241 SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM 300 + PVT++DQ+ DNII+ETLNHEHYECKYVI+AIPP LTAKIHF+PELP ERNQLIQRLPM Sbjct: 241 NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPM 300 Query: 301 GAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADR 360 GAVIKCM+YYKEAFWKKKDYCGCMIIEDE+API+ITLDDTKPDGSLPAIMGFILARKADR Sbjct: 301 GAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADR 360 Query: 361 QAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG 420 AKLHK+IRK+KICELYAKVLGSQEAL+PVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG Sbjct: 361 LAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG 420 Query: 421 RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKD 480 RVIRQPVGRI+FAGTETAT+WSGYMEGAVEAGERAAREVLN LGKV +KDIWV+EPESKD Sbjct: 421 RVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKD 480 Query: 481 VPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLP 525 VPA+EITHTF ERNLPSV GLLKI G STSV L FVLYK K LP Sbjct: 481 VPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLP 525 >2BK5-A nrPDB Length = 520 Score = 679 bits (1752), Expect = 0.0, Method: Composition-based stats. Identities = 368/504 (73%), Positives = 433/504 (85%), Gaps = 2/504 (0%) Query: 23 ISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSK 82 ISG+AAAKLL + +NV+VLEARDRVGGRTYT+RN+ VK+VD+GG+YVGPTQNRILRL+K Sbjct: 14 ISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAK 73 Query: 83 ELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDA 142 ELG+ETYKVN ERL+ +VKGK+YPFRG FPPVWNP+ YLD+NN WRTMD+MG+EIP DA Sbjct: 74 ELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDA 133 Query: 143 PWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCG 202 PW+A A+EWD MTMK+L+DK+CWT++A++ A LFVN+ VT+E HEVSALWFLWYV+QCG Sbjct: 134 PWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCG 193 Query: 203 GTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHE 262 GT RIFS TNGGQERKFVGGSGQVSE+IM LLGD+VKL PV YIDQT +N++VETLNHE Sbjct: 194 GTTRIFSTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHE 253 Query: 263 HYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCG 322 YE KYVISAIPP L KIHF P LP RNQ+I R+P+G+VIKC+VYYKE FW+KKDYCG Sbjct: 254 MYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCG 313 Query: 323 CMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLG 382 MII+ EEAP+A TLDDTKP+G+ AIMGFILA KA + A+L K+ R +K+CELYAKVLG Sbjct: 314 TMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLG 373 Query: 383 SQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWS 442 S EAL PVHYEEKNWCEEQYSGGCYT YFPPGI+TQYGRV+RQPV RIYFAGTETAT WS Sbjct: 374 SLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWS 433 Query: 443 GYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLL 502 GYMEGAVEAGERAARE+L+A+GK+ + +IW EPES DVPA IT TFLER+LPSVPGLL Sbjct: 434 GYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLL 493 Query: 503 KITGVST--SVALLCFVLYKIKKL 524 ++ G++T S L F+ +K L Sbjct: 494 RLIGLTTIFSATALGFLAHKRGLL 517 >3RHA-A nrPDB Length = 482 Score = 421 bits (1083), Expect = e-118, Method: Composition-based stats. Identities = 136/450 (30%), Positives = 224/450 (49%), Gaps = 9/450 (2%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQ 74 DV ++G G SGL AA+ L + ++V VLEARDRVGGRT+T + +++GG +V P Q Sbjct: 9 DVVIVGAGPSGLTAARELKKAGLSVAVLEARDRVGGRTWTDTIDGAM-LEIGGQWVSPDQ 67 Query: 75 NRILRLSKELGIETY-KVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDE 133 ++ L ELG++ Y + E + GK + G PV N + + L +DE Sbjct: 68 TVLMELLDELGLKMYSRYRDGESVYIGADGKRTQYTGDTFPV-NETTKAEMDKLVAILDE 126 Query: 134 MGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEP-HEVSAL 192 + EI PW A+E D ++ + + + A LF+ + ++P H SAL Sbjct: 127 LAAEIGPTEPWAHPKARELDTISFHHWLRQNSNDEEACNNIGLFIAGGMLTKPAHAFSAL 186 Query: 193 WFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDD 252 + G + + + + +++ +GG QVS LGD V L+SPV I + D+ Sbjct: 187 QAVLMAASAGSFSHL-TDEDFILDKRVIGGMQQVSLLQAAELGDDVVLNSPVRTI-KWDE 244 Query: 253 NIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKE 312 N + ++VI A+PP L +++ F P LP ++Q+ Q +G VIK Y Sbjct: 245 NGVSVVSERATVNARFVIMAVPPNLYSRVSFDPPLPRRQHQMHQHQSLGLVIKVHAVYDT 304 Query: 313 AFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRK 372 FW+++ G A + D+T S ++GF+ KAD +L + RK+ Sbjct: 305 PFWREEGLSGTGF--SAGALVQEVYDNTNHGDSRGTLVGFVSDEKADAVFELSAEDRKKA 362 Query: 373 ICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYF 432 I E A LG + AL P Y E +W E+++ G Y + + G + +YG+ VG IY+ Sbjct: 363 ILESIAGFLGDK-ALTPEVYYESDWGSEEWTRGAYASSYDLGGLHRYGKDQHANVGPIYW 421 Query: 433 AGTETATQWSGYMEGAVEAGERAAREVLNA 462 + ++ A + +++GAV G+ A ++ A Sbjct: 422 SSSDLAAEGYQHVDGAVRMGQATAARIVEA 451 >3KVE-A nrPDB Length = 486 Score = 399 bits (1024), Expect = e-111, Method: Composition-based stats. Identities = 107/487 (21%), Positives = 190/487 (39%), Gaps = 65/487 (13%) Query: 9 LAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGA 68 + V ++G G+SGL+AA +L+ V VLEA +R GGR T RN W G Sbjct: 29 KTSNPKHVVVVGAGMSGLSAAYVLAGAGHKVTVLEASERAGGRVRTHRNSKEGWYANLGP 88 Query: 69 YVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLW 128 P ++RI+R I + +N+NE + N A+ N+ Sbjct: 89 MRIPEKHRIVREY----IRKFGLNLNEFSQE-----------------NDNAWYFIKNIR 127 Query: 129 RTMDEMGKE-----IPVDAPWQARHAQEWDKMTMKDLIDKICWTK---------TAREFA 174 + + E+ K+ PV + + A + + ++ + + T T Sbjct: 128 KRVGEVNKDPGLLKYPVKPSEEGKSAGQLYEESLGSAVKDLKRTNCSYILNKYDTYSTKE 187 Query: 175 YLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTN---GGQERKF---VGGSGQVSE 228 YL N++ P V + L + I S+ + E++F VGG Q+ Sbjct: 188 YLIKEGNLS--PGAVDMIGDLLNEDSGYYVSFIESLKHDDIFAYEKRFDEIVGGMDQLPT 245 Query: 229 QIMGLLGDKVKLSSPVTYIDQTDDNIIVET----LNHEHYECKYVISAIPPILTAKIHFK 284 + + +KVK ++ V I Q + + V + YVI +I F+ Sbjct: 246 SMYRAIEEKVKFNARVIKIQQNANQVTVTYQTPEKDTSSNTADYVIVCTTSRAARRIQFE 305 Query: 285 PELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDG 344 P LPP++ ++ + + K + FW+ G D + P+ Sbjct: 306 PPLPPKKQHALRSVHYRSGTKIFLTCSSKFWEDDGIHGGKSTTDLPSRFIYY-----PNH 360 Query: 345 SLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLG---------SQEALYPVHYEEK 395 + +G I+A A + ++ + ++ L Q YP + Sbjct: 361 NFSTGVGVIIAYGIGDDANFFQALKFKDCADIVFNDLSLIHQLPKEEIQSFCYPSMIQ-- 418 Query: 396 NWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERA 455 W ++Y+ G T F P ++ + P GRI+FAG TA + G+++ +++G A Sbjct: 419 KWSLDKYAMGAITT-FTPYQFQRFSEALTAPQGRIFFAGEYTA-EAHGWIDSTIKSGLTA 476 Query: 456 AREVLNA 462 AR+V A Sbjct: 477 ARDVNRA 483 >1REO-A nrPDB Length = 486 Score = 392 bits (1007), Expect = e-109, Method: Composition-based stats. Identities = 106/484 (21%), Positives = 193/484 (39%), Gaps = 65/484 (13%) Query: 12 HMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVG 71 + V ++G G+SGL+AA +LS V VLEA +R GGR T RN+ W G Sbjct: 32 NPKHVVVVGAGMSGLSAAYVLSGAGHQVTVLEASERAGGRVRTYRNDKEDWYANLGPMRL 91 Query: 72 PTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTM 131 P ++RI+R I + + +NE + N A+ N+ + + Sbjct: 92 PEKHRIVREY----IRKFGLQLNEFSQE-----------------NDNAWYFIKNIRKRV 130 Query: 132 DEMGKE-----IPVDAPWQARHAQEWDKMTMKDLIDKICWTK---------TAREFAYLF 177 E+ K+ PV + + A + + ++ +++++ T T YL Sbjct: 131 GEVKKDPGVLKYPVKPSEEGKSAGQLYEESLGKVVEELKRTNCSYILNKYDTYSTKEYLL 190 Query: 178 VNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTN---GGQERKF---VGGSGQVSEQIM 231 N++ P V + L + S+ + E++F VGG ++ + Sbjct: 191 KEGNLS--PGAVDMIGDLMNEDSGYYVSFPESLRHDDIFAYEKRFDEIVGGMDKLPTSMY 248 Query: 232 GLLGDKVKLSSPVTYIDQTDDNIIVETLNHE----HYECKYVISAIPPILTAKIHFKPEL 287 + +KV L++ V I + + + V YVI T +I F+P L Sbjct: 249 RAIEEKVHLNAQVIKIQKNAEKVTVVYQTPAKEMASVTADYVIVCTTSRATRRIKFEPPL 308 Query: 288 PPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLP 347 PP++ ++ + + K + + FW+ + G D + P+ + Sbjct: 309 PPKKAHALRSVHYRSGTKIFLTCTKKFWEDEGIHGGKSTTDLPSRFIYY-----PNHNFT 363 Query: 348 AIMGFILARKADRQAKLHKDIRKRKICELYAKVLG---------SQEALYPVHYEEKNWC 398 + +G I+A A + + + ++ L Q YP + W Sbjct: 364 SGVGVIIAYGIGDDANFFQALDFKDCADIVINDLSLIHQLPREEIQTFCYPSMIQ--KWS 421 Query: 399 EEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAARE 458 ++Y+ G T F P + + V RIYFAG TA + G+++ +++G RAAR+ Sbjct: 422 LDKYAMGGITT-FTPYQFQHFSESLTASVDRIYFAGEHTA-EAHGWIDSTIKSGLRAARD 479 Query: 459 VLNA 462 V A Sbjct: 480 VNRA 483 >2VVL-G nrPDB Length = 495 Score = 387 bits (993), Expect = e-108, Method: Composition-based stats. Identities = 106/482 (21%), Positives = 193/482 (40%), Gaps = 43/482 (8%) Query: 2 TDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVK 61 T++E + G +DV +IGGG GL A + L+ L+LEARDR+GGR+++ + Sbjct: 29 TNIEDTDKDG-PWDVIVIGGGYCGLTATRDLTVAGFKTLLLEARDRIGGRSWSSNIDGYP 87 Query: 62 WVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAY 121 ++GG +V Q+ + R + N + +G + P + + Sbjct: 88 -YEMGGTWVHWHQSHVWREITRYKMH----NALSPSFNFSRGVNHFQLRTNPTTSTYMTH 142 Query: 122 LDYNNLWRT-------MDEMGKEIPVDAPWQARHAQE---WDKMTMKDLIDKICWTKTAR 171 + L R+ +D + P + E +D+M+ + ID+I + Sbjct: 143 EAEDELLRSALHKFTNVDGTNGRTVLPFPHDMFYVPEFRKYDEMSYSERIDQIRDELSLN 202 Query: 172 EFAYL--FVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQ 229 E + L F+ + S FL + G T + + KF G + + Sbjct: 203 ERSSLEAFILLCSGGTLENSSFGEFLHWWAMSGYTYQ--GCMDCLMSYKFKDGQSAFARR 260 Query: 230 IMGLL----GDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKP 285 PV + D V + + K V+ IP + + I F P Sbjct: 261 FWEEAAGTGRLGYVFGCPVRSVVNERDAARVTARDGREFVAKRVVCTIPLNVLSTIQFSP 320 Query: 286 ELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGS 345 L ER I + G V C + E KD I + + D G+ Sbjct: 321 ALSTER---ISAMQAGHVSMCTKVHAEV--DNKDMRSWTGIAYPFNKLCYAIGD----GT 371 Query: 346 LPAIMGFILARKAD-RQAKLHKDIRK--RKICELYAKVLGSQEALYPVHYEEKNWCEEQY 402 PA ++ D + +D+R+ + + +L G + ++ NW ++++ Sbjct: 372 TPAGNTHLVCFGTDANHIQPDEDVRETLKAVGQLAPGTFGVKRLVF------HNWVKDEF 425 Query: 403 SGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNA 462 + G + + PG++++ + +R+ G + FA ++ A W +++GA+E G RAAR VL Sbjct: 426 AKGAW-FFSRPGMVSECLQGLREKHGGVVFANSDWALGWRSFIDGAIEEGTRAARVVLEE 484 Query: 463 LG 464 LG Sbjct: 485 LG 486 >1F8S-A nrPDB Length = 498 Score = 385 bits (989), Expect = e-107, Method: Composition-based stats. Identities = 104/482 (21%), Positives = 183/482 (37%), Gaps = 65/482 (13%) Query: 12 HMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVG 71 + V ++G G++GL+AA +L+ V VLEA +R GGR T RNE W G Sbjct: 32 NPKHVVIVGAGMAGLSAAYVLAGAGHQVTVLEASERPGGRVRTYRNEEAGWYANLGPMRL 91 Query: 72 PTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTM 131 P ++RI+R I + + +NE + N A+ N+ + + Sbjct: 92 PEKHRIVREY----IRKFDLRLNEFSQE-----------------NDNAWYFIKNIRKKV 130 Query: 132 DEMGKE-----IPVDAPWQARHAQEWDKMTMKDLIDKICWTK---------TAREFAYLF 177 E+ K+ PV + A + + ++ +++++ T T YL Sbjct: 131 GEVKKDPGLLKYPVKPSEAGKSAGQLYEESLGKVVEELKRTNCSYILNKYDTYSTKEYLI 190 Query: 178 VNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTN---GGQERKF---VGGSGQVSEQIM 231 +++ P V + L + I S+ + E++F V G ++ + Sbjct: 191 KEGDLS--PGAVDMIGDLLNEDSGYYVSFIESLKHDDIFAYEKRFDEIVDGMDKLPTAMY 248 Query: 232 GLLGDKVKLSSPVTYIDQTDDNIIVET----LNHEHYECKYVISAIPPILTAKIHFKPEL 287 + DKV ++ V I Q D + V YVI I F P L Sbjct: 249 RDIQDKVHFNAQVIKIQQNDQKVTVVYETLSKETPSVTADYVIVCTTSRAVRLIKFNPPL 308 Query: 288 PPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLP 347 P++ ++ + + K + FW+ G D + P+ + Sbjct: 309 LPKKAHALRSVHYRSGTKIFLTCTTKFWEDDGIHGGKSTTDLPSRFIYY-----PNHNFT 363 Query: 348 AIMGFILARKADRQAKLHKDIRKRKICELYAKVLG---------SQEALYPVHYEEKNWC 398 +G I+A A + + + ++ L Q YP + W Sbjct: 364 NGVGVIIAYGIGDDANFFQALDFKDCADIVFNDLSLIHQLPKKDIQSFCYPSVIQ--KWS 421 Query: 399 EEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAARE 458 ++Y+ G T F P + + GRIYFAG TA Q G+++ +++G RAAR+ Sbjct: 422 LDKYAMGGITT-FTPYQFQHFSDPLTASQGRIYFAGEYTA-QAHGWIDSTIKSGLRAARD 479 Query: 459 VL 460 V Sbjct: 480 VN 481 >6CR0-A nrPDB Length = 440 Score = 370 bits (950), Expect = e-103, Method: Composition-based stats. Identities = 103/469 (21%), Positives = 196/469 (41%), Gaps = 50/469 (10%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGP 72 ++D ++G G SGL AA+ LS +VL++EAR R+GGRT+ V N + V++GGA V Sbjct: 8 IYDAIVVGAGFSGLVAARELSAQGRSVLIIEARHRLGGRTHVV-NFLGRPVEIGGAGVHW 66 Query: 73 TQNRILRLSKELGI---ETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWR 129 Q + + G E ++++ + + G+ P ++ +Y + Sbjct: 67 CQPHVFAEMQRYGFGFKEAPLADLDKAYMVFADGQKIDVP---PATFDE----EYTTAFE 119 Query: 130 TMDEMGKEIPVDA--PWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVT---- 183 +E+ P D ++ +D ++ + E +N +T Sbjct: 120 KFCSRSRELFPRPYSPLDNHEVSNLDGVSARDHLESLGLN----ELQLASMNAELTLYGG 175 Query: 184 SEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSP 243 + E+S F+ + + + T+ + GG+ + + I + P Sbjct: 176 APTTELSYPSFVKF--HALASWDTITFTDSEKRYHVQGGTNALCQAIFDDCRADSEFGVP 233 Query: 244 VTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAV 303 V + QTD+ + V + + + +P + A + F+P LPPE+ I+ M Sbjct: 234 VEAVAQTDNGVTVTLADKRVFRALTCVLTLPTKVYADVRFEPPLPPEKRAFIEHAEMADG 293 Query: 304 IKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAI-----MGFILARKA 358 + V+ ++ +C DD P ++ +G IL Sbjct: 294 AELYVHVRQNLGNTFTFC----------------DDPNPFNAVQTYAYDDELGTILKITI 337 Query: 359 DRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQ 418 RQ+ ++ + E+ K+ G E L + Y NW ++Y+ Y A G ++ Sbjct: 338 GRQSLINLENFDAIAAEI-RKIHGDVEVLEALPY---NWAMDEYARTSYPA-MRKGWFSR 392 Query: 419 YGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVA 467 Y + + +P R++FAG+ TA W Y++GA+E+G R RE+ + + A Sbjct: 393 Y-KDMAKPENRLFFAGSATADGWHEYIDGAIESGIRVGREIRHFMKATA 440 >4FWE-A nrPDB Length = 796 Score = 365 bits (936), Expect = e-101, Method: Composition-based stats. Identities = 108/463 (23%), Positives = 173/463 (37%), Gaps = 31/463 (6%) Query: 9 LAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGA 68 H V +IG G +GLAAA+ L + I V VLEA+DR+GGR + ++ V G Sbjct: 352 KDYHNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDKSFKGVTVGRGAQ 411 Query: 69 YV-GPTQNRILRLSKELGIETYKVNVNERLVQ---YVKGKTYPFRGAFPPVWNPLAYLDY 124 V G N + + ++LGI +K L+Q + T R F A LD Sbjct: 412 IVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTIDKRMDFHF----NALLDV 467 Query: 125 NNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDL-IDKICWTKTAREFAYLFVNINVT 183 + WR +++P+ +E K +K+ I +F + Sbjct: 468 VSEWRKDKTQLQDVPL-----GEKIEEIYKAFIKESGIQFSELEGQVLQFHLSNLEYACG 522 Query: 184 SEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSP 243 S H+VSA W + F G G + E++ G ++L SP Sbjct: 523 SNLHQVSARS--WDHNE-------FFAQFAGDHTLLTPGYSVIIEKLAE--GLDIQLKSP 571 Query: 244 VTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAK--IHFKPELPPERNQLIQRLPMG 301 V ID + D + V T + Y + V+ +P L K I F P L ++ + I L G Sbjct: 572 VQCIDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAG 631 Query: 302 AVIKCMVYYKEAFWKKK----DYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARK 357 + K + + FW K D+ G + + + D P +M I Sbjct: 632 IIEKIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEA 691 Query: 358 ADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMT 417 L ++ ++ QE P Y W + + Y+ G Sbjct: 692 VASVRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGE 751 Query: 418 QYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVL 460 Y + G ++FAG T + + GA +G R A ++ Sbjct: 752 AYDIIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIA 794 >3L1R-A nrPDB Length = 478 Score = 335 bits (859), Expect = 2e-92, Method: Composition-based stats. Identities = 110/487 (22%), Positives = 207/487 (42%), Gaps = 70/487 (14%) Query: 16 VGLIGGGISGLAAAKLLSEYKI-NVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYV---- 70 V ++G G+SG++AAK LSE I ++L+LEA D +GGR + + V++G +V Sbjct: 7 VIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGIN-VELGANWVEGVN 65 Query: 71 GPTQNRILRLSKE-LGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWR 129 G N I + L + ++ + + Y+ Y G V++ L Sbjct: 66 GGKMNPIWPIVNSTLKLRNFRSDFD-----YLAQNVYKEDGG---VYDEDYVQKRIELAD 117 Query: 130 TMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDK--------ICWTKTAREFAYLFVNI- 180 +++EMG+++ A A + + M+ L + + +F Y F Sbjct: 118 SVEEMGEKL--SATLHASGRDDMSILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPP 175 Query: 181 NVTSEPHEVSALWF------LWYV-RQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGL 233 VTS + V F +++V Q G A ++ + GQ K SG++ + Sbjct: 176 RVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYL--AGQYLKTDDKSGKIVDP---- 229 Query: 234 LGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYV-ISAIPPILTAK-IHFKPELPPER 291 +++L+ V I + + V+T ++ Y YV +SA +L + I FKP+LP + Sbjct: 230 ---RLQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFKPKLPTWK 286 Query: 292 NQLIQRLPMGAVIKCMVYYKEAFW-------------KKKDYCGCMIIEDEEAPIAITLD 338 + I + M + + FW ++ Y G +++ P A L Sbjct: 287 VRAIYQFDMAVYTMIFLKFPRKFWPEGKGREFFLYASSRRGYYGVWQEFEKQYPDANVLL 346 Query: 339 DTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWC 398 T D +R+ ++Q+ + K +I ++ K+ ++ W Sbjct: 347 VTVTDEE---------SRRIEQQS---DEQTKAEIMQVLRKMFPGKDVPDATDILVPRWW 394 Query: 399 EEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAARE 458 +++ G ++ + P G+ +R PVGR+YF G T+ ++GY+ GA +G +A Sbjct: 395 SDRFYKGTFSNW-PVGVNRYEYDQLRAPVGRVYFTGEHTSEHYNGYVHGAYLSGIDSAEI 453 Query: 459 VLNALGK 465 ++N K Sbjct: 454 LINCAQK 460 >3NK2-X nrPDB Length = 431 Score = 319 bits (816), Expect = 3e-87, Method: Composition-based stats. Identities = 114/469 (24%), Positives = 194/469 (41%), Gaps = 67/469 (14%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKW--VDVGGAYV 70 M+D ++GGG SGL AA+ L+ VL+LE +R+GGR Y+ + +V V++GGAY+ Sbjct: 1 MYDAIVVGGGFSGLKAARDLTNAGKKVLLLEGGERLGGRAYSRESRNVPGLRVEIGGAYL 60 Query: 71 GPTQNR-ILRLSKELGIETYK----VNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYN 125 + + GI T + RL + +P G+ Y Sbjct: 61 HRKHHPRLAAELDRYGIPTAAASEFTSFRHRLGPTAVDQAFPIPGSEAVAVEAATYTLLR 120 Query: 126 NLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSE 185 + R E G + + ++ D + + + +DK+ +R+F L N+ + Sbjct: 121 DAHRIDLEKG--------LENQDLEDLD-IPLNEYVDKLDLPPVSRQF-LLAWAWNMLGQ 170 Query: 186 P-HEVSALWFLWYVRQCGGTARIFSVTNG--GQERKFVGGSGQVSEQIMGLLGDKVKLSS 242 P + SALW L V A +S+ + F GS + + + + +++L + Sbjct: 171 PADQASALWMLQLVA-----AHHYSILGVVLSLDEVFSNGSADLVDAMSQEI-PEIRLQT 224 Query: 243 PVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGA 302 VT IDQ+ D + V + ++ VI A P +I F P LP R +I+ G Sbjct: 225 VVTGIDQSGDVVNVTVKDGHAFQAHSVIVATPMNTWRRIVFTPALPERRRSVIEEGHGGQ 284 Query: 303 VIKCMVYYKEA-----------FWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMG 351 +K +++ + A F DYC + E E +A T Sbjct: 285 GLKILIHVRGAEAGIECVGDGIFPTLYDYC--EVSESERLLVAFT--------------- 327 Query: 352 FILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYF 411 D + DI K LY L E L + +W + G + A Sbjct: 328 -------DSGSFDPTDIGAVKDAVLY--YLPEVEVL---GIDYHDWIADPLFEGPWVAP- 374 Query: 412 PPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVL 460 G ++ + + +P GRI+F G++ + ++ GY+EGA+E E A +L Sbjct: 375 RVGQFSRVHKELGEPAGRIHFVGSDVSLEFPGYIEGALETAECAVNAIL 423 >3ABT-A nrPDB Length = 662 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 61/386 (15%), Positives = 123/386 (31%), Gaps = 46/386 (11%) Query: 104 KTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDK 163 + Y P + A + R + + KE A Q + ++ ++ D Sbjct: 289 QQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDV 348 Query: 164 --ICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVG 221 + ++ + + + +S L + Q G Sbjct: 349 YLSSRDRQILDWHFANLEFANATPLSTLS----LKHWDQDDD------FEFTGSHLTVRN 398 Query: 222 GSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEH------YECKYVISAIPP 275 G V + G +KL++ V + T V +N Y+C V+ +P Sbjct: 399 GYSCVPVALAE--GLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPL 456 Query: 276 ILTAK----IHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKK----KDYCGCMIIE 327 + + + F P LP + +QR+ G + K ++ + FW + G Sbjct: 457 GVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTAS 516 Query: 328 DEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEAL 387 E + L P ++ + A + D+ + + + GS Sbjct: 517 RGELFLFWNLYKA------PILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVP 570 Query: 388 YPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIR------------QPVGRIYFAGT 435 P W + ++ G Y+ Y + + QP+ R++FAG Sbjct: 571 QPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGE 630 Query: 436 ETATQWSGYMEGAVEAGERAAREVLN 461 T + + GA+ +G R A + + Sbjct: 631 HTIRNYPATVHGALLSGLREAGRIAD 656 Score = 141 bits (354), Expect = 9e-34, Method: Composition-based stats. Identities = 55/203 (27%), Positives = 95/203 (46%), Gaps = 24/203 (11%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYV-GPTQ 74 V +IG G+SGLAAA+ L + ++V +LEARDRVGGR T R + D+G V G Sbjct: 110 VIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNY-VADLGAMVVTGLGG 168 Query: 75 NRILRLSKELGIETYKVNVNERLVQYVKGKTYPF------RGAFPPVWNPLAY----LDY 124 N + +SK++ +E K+ L + G+ P F + +Y LD+ Sbjct: 169 NPMAVVSKQVNMELAKIKQKCPLYE-ANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDF 227 Query: 125 NNLWRTMDEMGKEIPVDAPWQARHAQE-----WDKMT-----MKDLIDKICWTKTA-REF 173 N L +G+ + V Q +H ++ W K+ +K+L++K+ K +E Sbjct: 228 NVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKEL 287 Query: 174 AYLFVNINVTSEPHEVSALWFLW 196 + + P +++A + + Sbjct: 288 HQQYKEASEVKPPRDITAEFLVK 310 >5L3D-A nrPDB Length = 852 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 60/386 (15%), Positives = 123/386 (31%), Gaps = 46/386 (11%) Query: 104 KTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDK 163 + Y P + A + R + + KE A Q + ++ ++ D Sbjct: 460 QQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDV 519 Query: 164 --ICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVG 221 + ++ + + + +S L + Q G Sbjct: 520 YLSSRDRQILDWHFANLEFANATPLSTLS----LKHWDQDDD------FEFTGSHLTVRN 569 Query: 222 GSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEH------YECKYVISAIPP 275 G V + G +KL++ V + T V +N Y+C V+ +P Sbjct: 570 GYSCVPVALAE--GLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPL 627 Query: 276 ILTAK----IHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKK----KDYCGCMIIE 327 + + + F P LP + +QR+ G + K ++ + FW + G Sbjct: 628 GVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTAS 687 Query: 328 DEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEAL 387 E + L P ++ + A + D+ + + + GS Sbjct: 688 RGELFLFWNLYKA------PILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVP 741 Query: 388 YPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIR------------QPVGRIYFAGT 435 P W + ++ G ++ Y + + QP+ R++FAG Sbjct: 742 QPKETVVSRWRADPWARGSHSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGE 801 Query: 436 ETATQWSGYMEGAVEAGERAAREVLN 461 T + + GA+ +G R A + + Sbjct: 802 HTIRNYPATVHGALLSGLREAGRIAD 827 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 55/203 (27%), Positives = 95/203 (46%), Gaps = 24/203 (11%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYV-GPTQ 74 V +IG G+SGLAAA+ L + ++V +LEARDRVGGR T R + D+G V G Sbjct: 281 VIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNY-VADLGAMVVTGLGG 339 Query: 75 NRILRLSKELGIETYKVNVNERLVQYVKGKTYPF------RGAFPPVWNPLAY----LDY 124 N + +SK++ +E K+ L + G+ P F + +Y LD+ Sbjct: 340 NPMAVVSKQVNMELAKIKQKCPLYE-ANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDF 398 Query: 125 NNLWRTMDEMGKEIPVDAPWQARHAQE-----WDKMT-----MKDLIDKICWTKTA-REF 173 N L +G+ + V Q +H ++ W K+ +K+L++K+ K +E Sbjct: 399 NVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKEL 458 Query: 174 AYLFVNINVTSEPHEVSALWFLW 196 + + P +++A + + Sbjct: 459 HQQYKEASEVKPPRDITAEFLVK 481 >3BI4-A nrPDB Length = 516 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 104/520 (20%), Positives = 178/520 (34%), Gaps = 93/520 (17%) Query: 16 VGLIGGGISGLAAAKLLSEYKI-NVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQ 74 V +IG GI+GL AA L + I + LVLEARDRVGGR TV + D+G ++ T Sbjct: 11 VIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGRKYDIGASWHHDT- 69 Query: 75 NRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNN--LWRTMD 132 L+ L +E ++++N+ ++V F + +D++ L +D Sbjct: 70 -----LTNPLFLEEAQLSLNDGRTRFV-----FDDDNFIYIDEERGRVDHDKELLLEIVD 119 Query: 133 EMGKEIPVDAPWQARHAQE--WDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVS 190 + Q + + ++ MK L+ + N + P Sbjct: 120 NEMSKFAELEFHQHLGVSDCSFFQLVMKYLL----------QRRQFLTNDQIRYLPQLCR 169 Query: 191 ALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDK-VKLSSPVTYIDQ 249 L + +A+ + G F V ++I +KLS V I + Sbjct: 170 YLELWHGLDWKLLSAKDTYFGHQG-RNAFALNYDSVVQRIAQSFPQNWLKLSCEVKSITR 228 Query: 250 TDD-NIIVETLNHEHYECKYVISAIPP-----------ILTAKIHFKPELPPERNQLIQR 297 N+ V + Y YVI +P L +I F+P L P + Sbjct: 229 EPSKNVTVNCEDGTVYNADYVIITVPQSVLNLSVQPEKNLRGRIEFQPPLKPVIQDAFDK 288 Query: 298 LPMGAVIKCMVYYKEAFW----------------------------------KKKDYCGC 323 + GA+ K + ++E W +++D Sbjct: 289 IHFGALGKVIFEFEECCWSNESSKIVTLANSTNEFVEIVRNAENLDELDSMLEREDSQKH 348 Query: 324 MIIEDEEAPIAIT-LDDTKPDGSLPAIMGFILARKADRQAKLHKDI--RKRKICELYAKV 380 + P+ L + S +M L + + + + + + K Sbjct: 349 TSVTCWSQPLFFVNLSKSTGVASFMMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKC 408 Query: 381 LGSQEALYPV---------------HYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQ 425 L S++ + + + NW + YS G Y+A FP + Sbjct: 409 LDSEDVIDGMRPIENIANANKPVLRNIIVSNWTRDPYSRGAYSACFPGDDPVDMVVAMSN 468 Query: 426 PVG-RIYFAGTETATQWSGYMEGAVEAGERAAREVLNALG 464 RI FAG T +G GA E+G R A + + L Sbjct: 469 GQDSRIRFAGEHTIMDGAGCAYGAWESGRREATRISDLLK 508 >2JB2-A nrPDB Length = 489 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 84/483 (17%), Positives = 158/483 (32%), Gaps = 38/483 (7%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVR----------------NEH 59 V ++GGG +GL +A L + V VLEAR R GGR +T R Sbjct: 14 VVVLGGGPAGLCSAFELQKAGYKVTVLEARTRPGGRVWTARGGSEETDLSGETQKCTFSE 73 Query: 60 VKWVDVGGAYVGPTQNRILRLSKELG--IETYKVNVNERLVQYVKGKTYPFRGAFPPVWN 117 + +VG + P + L +ELG I+ + V Y + + Sbjct: 74 GHFYNVGATRI-PQSHITLDYCRELGVEIQGFGNQNANTFVNYQSDTSLSGQSVTYRAAK 132 Query: 118 PLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLF 177 + + L + + G V + E+ DL D + ++R Sbjct: 133 ADTFGYMSELLKKATDQGALDQVLSREDKDALSEFL-SDFGDLSDDGRYLGSSRR--GYD 189 Query: 178 VNINVTSEPHEVSALWFLWYVRQCG---GTARIFSVTNGGQERKFVGGSGQVSEQIMGLL 234 + + V + G + F VGG ++ + Sbjct: 190 SEPGAGLNFGTEKKPFAMQEVIRSGIGRNFSFDFGYDQAMMMFTPVGGMDRIYYAFQDRI 249 Query: 235 G-DKVKLSSPVTYIDQTDDNIIVETL---NHEHYECKYVISAIPPILTAKIHFKPELPPE 290 G D + + VT + + + VE + + Y I IPP L ++ LP + Sbjct: 250 GTDNIVFGAEVTSMKNVSEGVTVEYTAGGSKKSITADYAICTIPPHLVGRLQNN--LPGD 307 Query: 291 RNQLIQRLPMGAVIKCMVYYKEAFWKKKD-YCGCMIIEDEEAPIAITLDDTKPDGSLPAI 349 ++ + K + Y +W+ +D G D++ + D + Sbjct: 308 VLTALKAAKPSSSGKLGIEYSRRWWETEDRIYGGASNTDKDISQIMFPYDHYNSDRGVVV 367 Query: 350 MGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTA 409 + ++ + L R K +++ G + +W +YS + Sbjct: 368 AYYSSGKRQEAFESLTHRQRLAKAIAEGSEIHGEKYTRDISSSFSGSWRRTKYSESAWAN 427 Query: 410 Y-----FPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALG 464 + G T + +PV +IYFAG + + GA+ + + + Sbjct: 428 WAGSGGSHGGAATPEYEKLLEPVDKIYFAGDHLS-NAIAWQHGALTSARDVVTHIHERVA 486 Query: 465 KVA 467 + A Sbjct: 487 QEA 489 >4IV9-A nrPDB Length = 557 Score = 148 bits (373), Expect = 5e-36, Method: Composition-based stats. Identities = 93/507 (18%), Positives = 177/507 (34%), Gaps = 66/507 (13%) Query: 16 VGLIGGGISGLAAAKLLSEYK-INVLVLEARDRVGGRTYTVRNEHVKW---VDVGGAYVG 71 V ++G GISGL AA L +V++ E+RDR+GGR ++ + + ++G Sbjct: 41 VAIVGAGISGLVAATELLRAGVKDVVLYESRDRIGGRVWSQVFDQTRPRYIAEMGAMRFP 100 Query: 72 PTQNRILRLSKELGIETYKVNVNERLVQ---YVKGKTYPFRGAFPPVWNPLAYLDYNNLW 128 P+ + K+ GI T + +V + +GK Y + P P + W Sbjct: 101 PSATGLFHYLKKFGISTSTTFPDPGVVDTELHYRGKRYHWPAGKKP---PELFRRVYEGW 157 Query: 129 RTMDEMGKEIP---VDAPWQ-----ARHAQEWDKMTMKDLIDKICWTKTAREFAYLFV-- 178 +++ G + + AP E + + ++ +F Sbjct: 158 QSLLSEGYLLEGGSLVAPLDITAMLKSGRLEEAAIAWQGWLNVFRDCSFYNAIVCIFTGR 217 Query: 179 ---NINVTSEPHEVSALWFL-------WYVRQCGGTARIFSVTNG--GQERKFVGGSGQV 226 + + P + L V Q G T + V NG +R G + Sbjct: 218 HPPGGDRWARPEDFELFGSLGIGSGGFLPVFQAGFTEILRMVINGYQSDQRLIPDGISSL 277 Query: 227 SEQIMG------LLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAK 280 + ++ L D+V S V I + + II++T E VI Sbjct: 278 AARLADQSFDGKALRDRVCF-SRVGRISREAEKIIIQTEAGEQRVFDRVIVTSSNRAMQM 336 Query: 281 IH----FKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAIT 336 IH + L + + ++ + K + + FW K + + + Sbjct: 337 IHCLTDSESFLSRDVARAVRETHLTGSSKLFILTRTKFWIKNKLPTTIQSDGLVRGV--Y 394 Query: 337 LDDTKPDGSLPAIMGFILARKADRQAK-----LHKDIRKRKICELYAKVLGS-QEALYPV 390 D +PD + +L+ + A+ K R + + + A + + L PV Sbjct: 395 CLDYQPDEPEGHGV-VLLSYTWEDDAQKMLAMPDKKTRCQVLVDDLAAIHPTFASYLLPV 453 Query: 391 HYEE------KNWCEEQYSGGCYTAYFPP---GIMTQYGRVIRQPVG----RIYFAGTET 437 + +W + +S G + +P + + + +Y AG Sbjct: 454 DGDYERYVLHHDWLTDPHSAGAFKLNYPGEDVYSQRLFFQPMTANSPNKDTGLYLAGCSC 513 Query: 438 ATQWSGYMEGAVEAGERAAREVLNALG 464 + G++EGAV+ +A VL + G Sbjct: 514 SFAG-GWIEGAVQTALNSACAVLRSTG 539 >5MOG-A nrPDB Length = 497 Score = 144 bits (363), Expect = 9e-35, Method: Composition-based stats. Identities = 80/491 (16%), Positives = 175/491 (35%), Gaps = 42/491 (8%) Query: 3 DLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKW 62 + E+P V + G G++GL+ AK L++ ++LEARD +GG+ ++E W Sbjct: 10 NSEQPTK---PLQVVIAGAGLAGLSTAKYLADAGHKPILLEARDVLGGKIAAWKDEDGDW 66 Query: 63 VDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGK------TYPFRGAFPPVW 116 + G I L ELGI ++ E + + + F P Sbjct: 67 YETGLHIFFGAYPNIQNLFGELGIND-RLQWKEHSMIFAMPNKPGEFSRFDFPETLPAPL 125 Query: 117 NPL-AYLDYNNLWRTMDEMGKEIPVDAPWQA--RHAQEWDKMTMKDLIDKICWTKTARE- 172 N + A L N + +++ + + + + D T+ + + K + Sbjct: 126 NGIWAILRNNEMLTWPEKVKFALGLLPAMVGGQAYVEAQDGFTVSEWMKKQGVPDRVNDE 185 Query: 173 -FAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGS--GQVSEQ 229 F + +N P E+S L + + G + F+ G+ ++ Sbjct: 186 VFIAMSKALNFI-NPDELSMQCILIALNRFLQEKH-------GSKMAFLDGNPPERLCMP 237 Query: 230 IMG---LLGDKVKLSSPVTYIDQTDDNII--VETLNHEHYECKYVISAIPPILTAKIHFK 284 I+ LG +V+L+S + I+ D + + + A P + + Sbjct: 238 IVDHVRSLGGEVRLNSRIQKIELNPDGTVKHFALTDGTQITGDAYVFATPVDILKLLV-- 295 Query: 285 PELPPERN----QLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDT 340 P+ + + +++L VI +++ D+ +++ Sbjct: 296 PQ--EWKEISYFKKLEKLVGVPVINVHIWFDRKLKNTYDHLLFSRSSLLSVYADMSVTCK 353 Query: 341 KPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEE 400 + +++ + A + + +I + + AK+ + A + + Sbjct: 354 EYYDPNRSMLELVFAPAEEWVGRSDTEIIEAT-MQELAKLFPDEIAADQSKAKILKYHVV 412 Query: 401 QYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVL 460 + Y + R P+ Y AG T ++ MEGAV +G+ A+ V+ Sbjct: 413 KTPRSVYKTIPD---CEPCRPLQRSPIEGFYLAGDYTKQKYLASMEGAVLSGKLCAQSVV 469 Query: 461 NALGKVAKKDI 471 ++++ + Sbjct: 470 EDYKMLSRRSL 480 >3X0V-A nrPDB Length = 541 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 86/494 (17%), Positives = 166/494 (33%), Gaps = 62/494 (12%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVL---VLEARDRVGGRTYT--VRNEHVKWVDVGG 67 V ++G G+SGL A +L + KI L + E+ R GGR YT + + D+G Sbjct: 7 PRKVCIVGAGVSGLYIAMILDDLKIPNLTYDIFESSSRTGGRLYTHHFTDAKHDYYDIGA 66 Query: 68 AYVG--PTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPP--VWNPLAYLD 123 P+ R L K G+ K ++ + + +G P V Sbjct: 67 MRYPDIPSMKRTFNLFKRTGMPLIKYYLDGENTPQLYNNHFFAKGVVDPYMVSVANGGTV 126 Query: 124 YNNLWRTMDEMGKEIPVDAPWQARHAQEWDK----------MTMKDLIDKICWTKTAREF 173 +++ ++ E ++ ++ + A+++DK MT ++ + + A ++ Sbjct: 127 PDDVVDSVGEKLQQ--AFGYYKEKLAEDFDKGFDELMLVDDMTTREYLKRGGPKGEAPKY 184 Query: 174 AYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGG----QERKFVGGSGQVSEQ 229 + + T Q + I S + GG+ + + Sbjct: 185 DFFAIQWMETQNTGT-------NLFDQAFSESVIDSFDFDNPTKPEWYCIEGGTSLLVDA 237 Query: 230 IMGLLGDKVKLSSPVTYI----DQTDDNIIVETLNHEHYEC-KYVISAIPPILTAKIHFK 284 + L KV+ + V I D DD + + + Y V + ++ + Sbjct: 238 MKETLVHKVQNNKRVEAISIDLDAPDDGNMSVKIGGKDYSGYSTVFNTTALGCLDRMDLR 297 Query: 285 P-ELPPERNQLIQRLPMGAVIKCMVYYKEAFW-KKKDY-CGCMIIEDEEAPIA----ITL 337 L P + I+ L K + + +W K CG D L Sbjct: 298 GLNLHPTQADAIRCLHYDNSTKVALKFSYPWWIKDCGITCGGAASTDLPLRTCVYPSYNL 357 Query: 338 DDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKN- 396 DT L + A + K ++ EL +L + L+ H + Sbjct: 358 GDTGEAVLLASYTWSQDATRIGSLVKDAPPQPPKED-ELVELILQNLARLHAEHMTYEKI 416 Query: 397 ------------WCEEQYSGGCYTAYFPPGIMTQYGRVIRQPV--GRIYFAGTETATQWS 442 W + GG + A F PG + + +P G+ + G ++ Sbjct: 417 KEAYTGVYHAYCWANDPNVGGAF-ALFGPGQFSNLYPYLMRPAAGGKFHIVGEASSVH-H 474 Query: 443 GYMEGAVEAGERAA 456 ++ G++E+ A Sbjct: 475 AWIIGSLESAYTAV 488 >3WE0-A nrPDB Length = 580 Score = 112 bits (280), Expect = 4e-25, Method: Composition-based stats. Identities = 94/515 (18%), Positives = 168/515 (32%), Gaps = 68/515 (13%) Query: 10 AGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKW--VDVGG 67 A H +V ++G GI+GL AA L + + +V EA ++GGR + ++GG Sbjct: 62 ARHGEEVAIVGAGIAGLVAAYELMKLGLKPVVYEAS-KMGGRLRSQAFNGTDGIIAELGG 120 Query: 68 AYVGPTQNRILRLSKELGIET--YKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYN 125 + +LG+ET + + V A P + + Sbjct: 121 MRFPVSSTAFYHYVDKLGLETKPFPNPLTPASRSTVIDLEGQTYYAEKAADLPALFQEVT 180 Query: 126 NLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKIC---WTKTAREFAYLFVNINV 182 + W E G + ++ D +K+L + + +T +F Sbjct: 181 DAWADALESGARFGDI----QQAIRDRDVPRLKELWNTLVPLWDDRTFYDFVATSKAFAK 236 Query: 183 TSEPH-----EVSALWFLWYVRQCGGTARIFSV--TNGGQERK-FVGGSGQVSEQIMGLL 234 S H +V W IF V TN + VGG QV + I + Sbjct: 237 LSFQHREVFGQVGFGTGGWDSDFPNSMLEIFRVVMTNCDDHQHLVVGGVEQVPQGIWRHV 296 Query: 235 GDK------------VKLSSP---VTYIDQTDDNIIVETL---NHEHYECKYVISAIPP- 275 ++ + +P V I + D + T + HY V++ Sbjct: 297 PERCAHWPEGTSLSSLHGGAPRTGVKRIARASDGRLAVTDNWGDCRHYAA--VLTTCQSW 354 Query: 276 ILTAKIHFKPELPPERN-QLIQRLPMGAVIKCMVYYKEAFWKKKDYCGC-----MIIEDE 329 +LT +I + L ++ + R K V FWK KD M + D Sbjct: 355 LLTTQIDCEESLFSQKMWMALDRTRYMQSSKTFVMVDRPFWKDKDPETGRDLMSMTLTDR 414 Query: 330 EAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHK--DIRKRKICELYAKVLGSQEAL 387 D+ P ++ A +D L + R + + K+ + Sbjct: 415 LTRGTYLFDN---GDDKPGVICLSYAWMSDALKMLPHPVEKRVQLALDALKKIYPKTDIA 471 Query: 388 -----YPVHYEEKNWCEEQYSGGCYTAYFPP------GIMTQYGRVIRQPVGR-IYFAGT 435 P+ +W + + G + P + + + R I+ AG Sbjct: 472 GHIIGDPITI---SWEADPHFLGAFKGALPGHYRYNQRMYAHFMQAQMPVEQRGIFIAGD 528 Query: 436 ETATQWSGYMEGAVEAGERAAREVLNALGKVAKKD 470 + + ++EGAV+ A ++N G D Sbjct: 529 DVSWT-PAWVEGAVQTSLNAVWGIMNHFGGKTHAD 562 >1SEZ-A nrPDB Length = 504 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 76/508 (14%), Positives = 166/508 (32%), Gaps = 78/508 (15%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQN 75 V +IG G+SGLAAA L + +NV V EA + GG+ +V + + W D G + ++ Sbjct: 16 VAVIGAGVSGLAAAYKLKIHGLNVTVFEAEGKAGGKLRSVSQDGLIW-DEGANTMTESEG 74 Query: 76 RILRLSKELGIE---TYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMD 132 + L LG+ + ++ N+R + R P + + + + Sbjct: 75 DVTFLIDSLGLREKQQFPLSQNKRYI---------ARNGTPVLLPSNPIDLIKSNFLSTG 125 Query: 133 EMGKEIPVDAPWQARHAQEWDK--MTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVS 190 + + W+ + + ++ + + FV +P +S Sbjct: 126 SKLQMLLEPILWKNKKLSQVSDSHESVSGFFQRHFGKEVVDYLIDPFVAGTCGGDPDSLS 185 Query: 191 A---LWFLWYVRQCGGTARIFSVTNGGQERK---------------------FVGGSGQV 226 LW + + G+ + ++ + + F+GG + Sbjct: 186 MHHSFPELWNLEKRFGSVILGAIRSKLSPKNEKKQGPPKTSANKKRQRGSFSFLGGMQTL 245 Query: 227 SEQIMGLLGDK-VKLSSPVTYI------DQTDDNIIVETLNHEHYEC-----KYVISAIP 274 ++ I L + ++L+S V + D D+ + + + + VI P Sbjct: 246 TDAICKDLREDELRLNSRVLELSCSCTEDSAIDSWSIISASPHKRQSEEESFDAVIMTAP 305 Query: 275 PILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEA------------FWKKKDYCG 322 + P I + + + +K K+ G Sbjct: 306 LCDVKSMKIAKRGNPFLLNFIPEVDYVPLSVVITTFKRENVKYPLEGFGVLVPSKEQQHG 365 Query: 323 CMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLG 382 + + + D P+ F+ + AK + K + ++LG Sbjct: 366 LKTLGTLFSSMMF--PDRAPNNVY-LYTTFVGGSRNRELAKASRTELKEIVTSDLKQLLG 422 Query: 383 SQEALYPVHYEEKNWCEE-QYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQW 441 ++ P + W + G Y + + + + +++AG + Sbjct: 423 AEG--EPTYVNHLYWSKAFPLYGHNYDSVLDA------IDKMEKNLPGLFYAGNH---RG 471 Query: 442 SGYMEGAVEAGERAAREVLNALGKVAKK 469 + A+ +G AA V++ L V+ Sbjct: 472 GLSVGKALSSGCNAADLVISYLESVSTD 499 >4IVM-B nrPDB Length = 483 Score = 82.2 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 98/487 (20%), Positives = 164/487 (33%), Gaps = 62/487 (12%) Query: 16 VGLIGGGISGLAAAKLLSEYKI--NVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPT 73 V ++GGGISGLAA+ LS V+++E+ +R+GG +VR + ++G + P Sbjct: 11 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPGGIRPA 70 Query: 74 ---QNRILRLSKELGIET--------YKVNVNERLVQYVKGKTYP-----FRGAFPPVWN 117 R L L ELG+++ + N L P PP Sbjct: 71 GALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSK 130 Query: 118 PLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLF 177 PL + L + GKE D + + +D +C A L Sbjct: 131 PLFWAGLRELTK---PRGKE--PDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELS 185 Query: 178 VNINVTS----EPHEVSALWFLWYVRQCGGTARIFSVTNGGQER----KFVGGSGQVSEQ 229 + S E S L L + ER GG + + Sbjct: 186 IRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQA 245 Query: 230 IMGLL---GDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPE 286 + L G V PV + + +L E +VISAIP + +++ Sbjct: 246 LETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSEL----- 300 Query: 287 LPPER---NQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLD----- 338 LP E + + + +V + Y+ A + + + ++ + I D Sbjct: 301 LPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFP 360 Query: 339 --DTKPDGSLPAIM--GFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEE 394 D P G +M G L L +++ +++ E A LG +E Sbjct: 361 EQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHL 420 Query: 395 KNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGY-MEGAVEAGE 453 C QY+ G + + + AG + G + +E+G Sbjct: 421 HKNCIPQYTLGHWQKLESARQF------LTAHRLPLTLAG----ASYEGVAVNDCIESGR 470 Query: 454 RAAREVL 460 +AA VL Sbjct: 471 QAAVSVL 477 >3LOV-A nrPDB Length = 475 Score = 79.5 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 68/410 (16%), Positives = 144/410 (35%), Gaps = 42/410 (10%) Query: 17 GLIGGGISGLAAAKLLSEY--KINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQ 74 ++GGGI+GLAAA +N+ +LEA +R+GG+ T R + ++ G + Sbjct: 8 VIVGGGITGLAAAYYAERAFPDLNITLLEAGERLGGKVATYREDGFT-IERGPDSYVARK 66 Query: 75 NRILRLSKELGIETYKVNVN-ERLVQYVKGKTYPFR-GAFPPVWNPLAYLDYNNLWRTMD 132 + + L + +G+ V N + G +P GA + L L + Sbjct: 67 HILTDLIEAIGLGEKLVRNNTSQAFILDTGGLHPIPKGAVMGIPTDLDLFRQTTLLTEEE 126 Query: 133 EMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVS-- 190 + + P + E D + + + + + ++ ++S Sbjct: 127 KQEVADLLLHPSDSLRIPEQD-IPLGEYLRPRLGDALVEKLIEPLLSGIYAGNIDQMSTF 185 Query: 191 --ALWFLWYVRQCGG---------------TARIFSVTNGGQERKFVGGSGQVSEQIMGL 233 F+ ++ G ++ GQ G + E++ + Sbjct: 186 ATYPQFVANEQKAGSLFEGMRLMRPLDQLPQTPQTTIKATGQFLSLETGLESLIERLEEV 245 Query: 234 L-GDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERN 292 L +++L +P+ I + D ++T + Y YV+ IP ++ LP Sbjct: 246 LERSEIRLETPLLAISREDGRYRLKTDHGPEY-ADYVLLTIPHPQVVQLLPDAHLPE--- 301 Query: 293 QLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAI---TLDDTKPDGSLP-- 347 +++L + + + + + G + + AP +I T D K + S P Sbjct: 302 --LEQLTTHSTATVTMIFDQQ--QSLPIEGTGFVVNRRAPYSITACTAIDQKWNHSAPDH 357 Query: 348 -AIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKN 396 + F+ D ++ ++ + + K+ G L P Sbjct: 358 TVLRAFVGRPGNDHLVHESDEVLQQAVLQDLEKICG--RTLEPKQVIISR 405 >2IVE-A nrPDB Length = 478 Score = 77.6 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 69/403 (17%), Positives = 128/403 (31%), Gaps = 25/403 (6%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQ 74 +V ++GGGISGLA A L + ++LE+ R+GG T V+ G + Sbjct: 18 NVAVVGGGISGLAVAHHLRSRGTDAVLLESSARLGGAVGTHALAGY-LVEQGPNSFLDRE 76 Query: 75 NRILRLSKELGIE---TYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTM 131 L+ L +E +R Y +G+ + PP + L R Sbjct: 77 PATRALAAALNLEGRIRAADPAAKRRYVYTRGRLRSVPAS-PPAFLASDILPLGARLRVA 135 Query: 132 DEM-GKEIP--VDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNIN---VTSE 185 E+ + P VD A + + L+D + A + L V + Sbjct: 136 GELFSRRAPEGVDESLAAFGRRHLGHRATQVLLDAVQTGIYAGDVEQLSVAATFPMLVKM 195 Query: 186 PHE-----VSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL 240 E + A+ RQ A +G F GG + + + LGD + Sbjct: 196 EREHRSLILGAIRAQKAQRQAALPAGTAPKLSGALST-FDGGLQVLIDALAASLGDAAHV 254 Query: 241 SSPVTYIDQTDDNIIVETLNH---EHYECKYVISAIPPILTAKIHFKPELPPERNQLIQR 297 + V + + D + H V+ A P TAK+ L L+ Sbjct: 255 GARVEGLAREDGGWRLIIEEHGRRAELSVAQVVLAAPAHATAKLL--RPLDDALAALVAG 312 Query: 298 LPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARK 357 + + + + D G ++ +E+ + + + + + Sbjct: 313 IAYAPIAVVHLGFDAGTLPAPDGFGFLVPAEEQRRMLGAIHASTTFPFRAEGGRVLYSCM 372 Query: 358 ADRQAKLHK-DIRKRKICELYAKVLGSQEALY--PVHYEEKNW 397 + + + + L + L + + P W Sbjct: 373 VGGARQPGLVEQDEDALAALAREELKALAGVTARPSFTRVFRW 415 >3I6D-A nrPDB Length = 470 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 91/471 (19%), Positives = 150/471 (31%), Gaps = 63/471 (13%) Query: 16 VGLIGGGISGLAAAKLL------SEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAY 69 V +IGGGI+GLAAA + + + ++EA RVGG+ TV+ + ++ G Sbjct: 8 VVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASPRVGGKIQTVKKDGY-IIERGPDS 66 Query: 70 VGPTQNRILRLSKELGIETYKVN---------VNERLVQYVKGKTYPFRGAFPPVWNPLA 120 + +L K+LG+E VN VN L KG P + Sbjct: 67 FLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRTLHPMPKGAVMGIPTKIAPFVSTGL 126 Query: 121 YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTK----------TA 170 + MD + +P + E+ + + D + + Sbjct: 127 FSLSGKARAAMDFI---LPASKTKDDQSLGEFFRRRVGDEVVENLIEPLLSGIYAGDIDK 183 Query: 171 REFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQI 230 F T + H L Q G+ + + GQ + G + E+I Sbjct: 184 LSLMSTFPQFYQTEQKHRSLILGMKKTRPQ--GSGQQLTAKKQGQFQTLSTGLQTLVEEI 241 Query: 231 MGLLGD-KVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPP 289 L KV + VT + + +E N + VI P A + ELP Sbjct: 242 EKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTLDADSVIVTAPHKAAAGML--SELPA 299 Query: 290 ERNQLIQRLPMGAVIKCMVYYKE--AFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLP 347 ++ + +V + + E + + + + A A T + K + P Sbjct: 300 --ISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVISRNSDFAITACTWTNKKWPHAAP 357 Query: 348 AIMGFILAR----KADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYS 403 + A + L + + E KV+ P W E Sbjct: 358 EGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLKKVMNING--EPEMTCVTRWHE---- 411 Query: 404 GGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSG-YMEGAVEAGE 453 M QY +Q RI A+ + G YM GA G Sbjct: 412 -----------SMPQYHVGHKQ---RIKELREALASAYPGVYMTGASFEGV 448 >4DGK-A nrPDB Length = 501 Score = 72.6 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 47/278 (16%), Positives = 96/278 (34%), Gaps = 39/278 (14%) Query: 18 LIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRI 77 +IG G GLA A L I VL+LE RD+ GGR Y ++ + G V + I Sbjct: 6 VIGAGFGGLALAIRLQAAGIPVLLLEQRDKPGGRAYVYEDQGFTFDA--GPTVITDPSAI 63 Query: 78 LRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKE 137 L G + + + + + W +Y+N ++ ++ Sbjct: 64 EELFALAGKQLKEYVELLPVTPFYR-----------LCWESGKVFNYDNDQTRLEAQIQQ 112 Query: 138 IPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEP--HEVSALWFL 195 R ++ + K+ K+ L + V + Sbjct: 113 FNPRDVEGYRQFLDYSRAVFKEGYLKLGTVPFLSFRDMLRAAPQLAKLQAWRSVYSKVAS 172 Query: 196 WYVRQCG----------------GTARIFSVTNGGQERKFV----GGSGQVSE---QIMG 232 + + T+ I+++ + + V GG+G + + ++ Sbjct: 173 YIEDEHLRQAFSFHSLLVGGNPFATSSIYTLIHALEREWGVWFPRGGTGALVQGMIKLFQ 232 Query: 233 LLGDKVKLSSPVTYIDQTDDNII-VETLNHEHYECKYV 269 LG +V L++ V++++ T + I V + + + V Sbjct: 233 DLGGEVVLNARVSHMETTGNKIEAVHLEDGRRFLTQAV 270 >1I8T-A nrPDB Length = 367 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 48/277 (17%), Positives = 85/277 (30%), Gaps = 42/277 (15%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGP 72 M+D ++G G+ G A L + VLV+E R+ +GG YT E ++ G Sbjct: 1 MYDYIIVGSGLFGAVCANELKKLNKKVLVIEKRNHIGGNAYTEDCEGIQIHKYGAHIFHT 60 Query: 73 TQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMD 132 I +L + N L Y K K + D ++ Sbjct: 61 NDKYIWDYVNDLV--EFNRFTNSPLAIY-KDKLFNLPFNMNTFHQMWGVKDPQEAQNIIN 117 Query: 133 EMGKEIPVDAPWQARHA------QEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEP 186 K+ P ++ + +K +K W ++A+E P Sbjct: 118 AQKKKYGDKVPENLEEQAISLVGEDLYQALIKGYTEK-QWGRSAKEL------------P 164 Query: 187 HEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTY 246 + + + + + VGG ++ E+++ G VKL Sbjct: 165 AFIIKRIPVRFTFDNNYFSDRYQGIP-------VGGYTKLIEKMLE--GVDVKLG----- 210 Query: 247 IDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHF 283 ID D + + +I P F Sbjct: 211 IDFLKDK------DSLASKAHRIIYTGPIDQYFDYRF 241 >5ZBC-A nrPDB Length = 451 Score = 61.4 bits (147), Expect = 9e-10, Method: Composition-based stats. Identities = 75/476 (15%), Positives = 146/476 (30%), Gaps = 77/476 (16%) Query: 12 HMFDVGLIGGGISGLAAAKLLSEY----KINVLVLEARDRVGGRTYTVRNEHVKWVDVGG 67 H D+ ++G GISGL A L + +++ + + + GGR + + +++G Sbjct: 23 HSSDICIVGAGISGLTCASHLLDSPACRGLSLRIFDMQQEAGGRIRSKMLDGKASIELGA 82 Query: 68 AYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKT--YPFRG-AFPPVWNPLAYLDY 124 P + + +Q+ K+ YPF F Sbjct: 83 GRYSPQLHPHF----------------QSAMQHYSQKSEVYPFTQLKFKSHVQQKLKRAM 126 Query: 125 NNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLF--VNINV 182 N L + E GKE + + + M D + + E AY + + Sbjct: 127 NELSPRLKEHGKESFLQFVSRYQGHDSAVGMIRSMGYDALFLPDISAEMAYDIVGKHPEI 186 Query: 183 TSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSS 242 S + WF + G G Q + + G + L Sbjct: 187 QSVTDNDANQWF---AAETGFA-----------------GLIQGIKAKVKAAGARFSLGY 226 Query: 243 PVTYIDQTDDNIIVETLN----HEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRL 298 + + D +++ + +++I AIPP A ++ L Sbjct: 227 RLLSVRTDGDGYLLQLAGDDGWKLEHRTRHLILAIPPSAMAGLNVDFP-EAWSGARYGSL 285 Query: 299 PMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDT----KPDGSLPAIMGFIL 354 P+ K + Y E +W ++I D D D + + Sbjct: 286 PL---FKGFLTYGEPWWLDYKLDDQVLIVDNPLRKIYFKGDKYLFFYTDSEMANYWRGCV 342 Query: 355 ARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEE-QYSGGCYTAYFPP 413 A + + + P+ + K W ++ + P Sbjct: 343 AEG-EDGYLEQIRTHLASALGIVRE-----RIPQPLAHVHKYWAHGVEFCRD--SDIDHP 394 Query: 414 GIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKK 469 ++ I A ++ T+ +G+MEG + + R A +L L ++A K Sbjct: 395 SALSHRDSGI--------IACSDAYTEHAGWMEGGLLSA-REASRLL--LQRIAAK 439 >5BR7-A nrPDB Length = 393 Score = 61.4 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 40/233 (17%), Positives = 75/233 (32%), Gaps = 21/233 (9%) Query: 14 FDVGLIGGGISGLAAAKLLSEY-KINVLVLEARDRVGGRTYTVR--NEHVKWVDVGGAYV 70 FD+ ++G G+ GL A+ + VL++E R +GG Y+ ++ G Sbjct: 4 FDLIVVGSGLFGLTVAERAASQLGKKVLIVEKRSHLGGNAYSEAEPETGIEIHKYGAHLF 63 Query: 71 GPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA-YLDYNNLWR 129 + R+ + T R+ G Y F + Y + Sbjct: 64 HTSNKRVWDYVNQF---TAFTGYQHRVFAMHNGTAYQFPMGLGLINQFFGRYYTPDEARE 120 Query: 130 TMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEV 189 + E EI ++ A ++ + + + A Y ++P E+ Sbjct: 121 LIKEQSAEI------DSKDATNLEEKAISLIGRPL---YEAFIRDYTAKQWQ--TDPKEL 169 Query: 190 SALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSS 242 A + R F+ T G V G Q + +V+L + Sbjct: 170 PAGNITRLPVRYNFDNRYFNDTYEGLP---VDGYAQWLSNMADHENIEVRLDT 219 >4RPJ-A nrPDB Length = 399 Score = 60.2 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 40/232 (17%), Positives = 74/232 (31%), Gaps = 19/232 (8%) Query: 14 FDVGLIGGGISGLA-AAKLLSEYKINVLVLEARDRVGGRTYTVR--NEHVKWVDVGGAYV 70 FD+ ++G G GL A ++ ++ VLVLE R +GG Y+ ++ G Sbjct: 8 FDLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGGNAYSEAEPQTGIEVHKYGAHLF 67 Query: 71 GPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRT 130 + R+ ++ T + R+ G+ Y F V R Sbjct: 68 HTSNKRVWDYVRQF---TDFTDYRHRVFAMHNGQAYQFPMGLGLVSQFFGKYFTPEQARQ 124 Query: 131 MDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVS 190 + QA D +++ + F + ++P E+ Sbjct: 125 L----------IAEQAAEIDTADAQNLEEKAISLIGRPLYEAFVKGYTAKQWQTDPKELP 174 Query: 191 ALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSS 242 A + R FS T G G + + +V+L++ Sbjct: 175 AANITRLPVRYTFDNRYFSDTYEGLP---TDGYTAWLQNMAADHRIEVRLNT 223 >5NMX-A nrPDB Length = 425 Score = 59.5 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 70/434 (16%), Positives = 131/434 (30%), Gaps = 62/434 (14%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGP 72 M V ++G G SGL AA+ L + V+V E VGG T+ +E ++ Sbjct: 1 MRRVAVLGAGPSGLTAARYLKQAGFEVMVFERYHHVGG-TWNYTDE---------TWMSE 50 Query: 73 TQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMD 132 + + VN+ + L+ + + G++ P L Y D N D Sbjct: 51 DGRPVYSSM----YQNLFVNLPKELMAFPDFPFHDIEGSYVPSKEVLKYFD--NFTDAFD 104 Query: 133 EMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSAL 192 + + + + + + D + + EF + V T + Sbjct: 105 LRKL---IKLQHHVENVRPCESGWLVTVTDLTTMVEHSFEFDAVVV---CTGQT------ 152 Query: 193 WFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQI-MGLLGDKVKLSSPVTYIDQTD 251 W Y G + +T+ + R + + G G + L +I Sbjct: 153 WCPLYPDVEGRSFFRGRLTHAHEFRSPEPFRNKRVLIVGAGPSGHDMAL-----HISYVS 207 Query: 252 DNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMG---AVIKCMV 308 + + + E + P +T K L ++ G V + + Sbjct: 208 KEVFLSRKELKPVEGLF-----PDNVTEK-----PLLTSLSEYTAHFSDGTSTDVDEILY 257 Query: 309 Y--YKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKA--DRQAKL 364 Y+ F CG + E P+ + + + L + + D QA+ Sbjct: 258 CTGYRYRFPFLSPECGVTVDEKYVYPLYLHMLNINKPTMLFIGVSYNACYSIMFDLQAQW 317 Query: 365 HKDIRKRKI----CELYAKVLGS------QEALYPVHYEEKNW-CEEQYSGGCYTAYFPP 413 + + E K EA++P W ++ PP Sbjct: 318 VTAVLAGRCTLPDAETMRKEEAEYMEKQRAEAVHPHVLMNHQWEYFKKLEEMSGAKTMPP 377 Query: 414 GIMTQYGRVIRQPV 427 M + V V Sbjct: 378 VYMKMFDDVASDLV 391 >4MO2-B nrPDB Length = 368 Score = 56.4 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 29/131 (22%), Positives = 51/131 (38%), Gaps = 4/131 (3%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGP 72 M+D ++G G+ G A +E LV+E R+ +GG YT +++ G Sbjct: 1 MYDYLIVGSGLFGSIFAYEATEKGYTCLVVEQREHIGGNCYTENIKNINVHKYGAHIFRT 60 Query: 73 TQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMD 132 + I + + +N + Y K + Y ++ L + N R + Sbjct: 61 SDQNIWDYMNQFC--EFNHFINSPIAIY-KDEIYNLPFNMN-TFSKLWGIKTPNEARKII 116 Query: 133 EMGKEIPVDAP 143 EM K+I P Sbjct: 117 EMQKQIIQHPP 127 >5EQD-A nrPDB Length = 400 Score = 56.0 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 41/233 (17%), Positives = 79/233 (33%), Gaps = 21/233 (9%) Query: 14 FDVGLIGGGISGLA-AAKLLSEYKINVLVLEARDRVGGRTYT--VRNEHVKWVDVGGAYV 70 FD+ ++G G GL A + ++ VLV+E R +GG Y+ ++ G Sbjct: 5 FDLFVVGSGFFGLTIAERAATQLGKRVLVIERRPHIGGNAYSEPEPETGIEVHKYGAHLF 64 Query: 71 GPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA-YLDYNNLWR 129 + R+ ++ T R+ G+ Y F V Y + Sbjct: 65 HTSNKRVWDYVRQF---TDFTGYQHRVFAMHNGQAYQFPMGLGLVSQFFGRYFSPDEARA 121 Query: 130 TMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEV 189 + E EI + A+ +++ + + + A Y ++P ++ Sbjct: 122 LIAEQASEI------DTKDAKNFEEKAISLVGRPL---YEAFIKHYTAKQWQ--TDPKDL 170 Query: 190 SALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSS 242 A + R F+ T G V G + E + +V+L + Sbjct: 171 PASNITRLPVRYTFDNRYFNDTYEGLP---VEGYTKWLENMAADERIEVRLDT 220 >4ZCC-A nrPDB Length = 336 Score = 55.6 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 25/128 (19%), Positives = 45/128 (35%), Gaps = 7/128 (5%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQN 75 + +IG GI+GL+AA+ L+ V + + GGR + R++ +D+G Y Sbjct: 5 IAIIGTGIAGLSAAQALTSAGHQVHLFDKSRGSGGRMSSKRSDAGS-LDMGAQYFTARDR 63 Query: 76 RILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMG 135 R K+ + + L + G+ P R Sbjct: 64 RFATAVKQWQAQGHVSEWTPLLYNFHGGRLSPSPDEQVRWVGEPGMSAITRAMR------ 117 Query: 136 KEIPVDAP 143 ++PV Sbjct: 118 GDLPVSFS 125 Score = 33.3 bits (74), Expect = 0.25, Method: Composition-based stats. Identities = 41/241 (17%), Positives = 85/241 (35%), Gaps = 28/241 (11%) Query: 221 GGSGQVSEQIMGLLGDKVKLSSPVTYI---DQTDDNIIVETLNHEHYECKYVISAIPPIL 277 G ++ + G L V S +T + +Q + + E+ NH + +VI A P Sbjct: 107 PGMSAITRAMRGDL--PVSFSCRITDVFRGEQHWNLLDAESENHGPFS--HVIIATPAPQ 162 Query: 278 TAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITL 337 + P+ ++ + M + ++ GC + + +A Sbjct: 163 ATALL---AAAPKLASVVAGVKMDPTWAVALAFETPLQTP--MQGCFVQDSPLDWLARNR 217 Query: 338 DDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNW 397 D +L + + ++ + + ++ + +A+++ PV W Sbjct: 218 SKPGRDDTLDSWVLHATSQWSRQNLDASREQVIEHLHGAFAELI-DCAMPAPVFSLAHRW 276 Query: 398 CEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAR 457 Y P ++G + +G IY G + SG +EGA +G+ AAR Sbjct: 277 L-----------YARPAGSHEWGALSDADLG-IYVCG-DWCL--SGRVEGAWLSGQEAAR 321 Query: 458 E 458 Sbjct: 322 R 322 >3KKJ-A nrPDB Length = 336 Score = 54.8 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 22/94 (23%), Positives = 40/94 (42%), Gaps = 1/94 (1%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQN 75 + +IG GI+GL+AA+ L+ V + + GGR + R++ +D+G Y Sbjct: 5 IAIIGTGIAGLSAAQALTAAGHQVHLFDKSRGSGGRMSSKRSDAGA-LDMGAQYFTARDR 63 Query: 76 RILRLSKELGIETYKVNVNERLVQYVKGKTYPFR 109 R K+ + + L + G+ P Sbjct: 64 RFATAVKQWQAQGHVAEWTPLLYNFHAGRLSPSP 97 Score = 36.7 bits (83), Expect = 0.025, Method: Composition-based stats. Identities = 38/241 (15%), Positives = 87/241 (36%), Gaps = 26/241 (10%) Query: 220 VGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYEC-KYVISAIP-PIL 277 G ++ + G + V S +T + + +++ + +++ +VI A P P Sbjct: 106 KPGMSAITRAMRGDM--PVSFSCRITEVFRGEEHWNLLDAEGQNHGPFSHVIIATPAPQA 163 Query: 278 TAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITL 337 + + P+L ++ + M + ++ GC + + +A Sbjct: 164 STLLAAAPKL----ASVVAGVKMDPTWAVALAFETPLQTP--MQGCFVQDSPLDWLARNR 217 Query: 338 DDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNW 397 + D +L + ++ + + ++ + +A+++ PV W Sbjct: 218 SKPERDDTLDTWILHATSQWSRQNLDASREQVIEHLHGAFAELI-DCTMPAPVFSLAHRW 276 Query: 398 CEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAR 457 Y P ++G + +G IY G + SG +EGA +G+ AAR Sbjct: 277 L-----------YARPAGAHEWGALSDADLG-IYVCG-DWCL--SGRVEGAWLSGQEAAR 321 Query: 458 E 458 Sbjct: 322 R 322 >3KYB-A nrPDB Length = 390 Score = 54.1 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 26/151 (17%), Positives = 49/151 (32%), Gaps = 11/151 (7%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNE--HVKWVDVGGAYVGPT 73 + ++G G SG + L+E V +++ RD +GG +Y R+ +V G Sbjct: 6 ILIVGAGFSGAVIGRQLAEKGHQVHIIDQRDHIGGNSYDARDSETNVMVHVYGPHIFHTD 65 Query: 74 QNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYL-DYNNLWRTMD 132 + + VN R+ V G+ + + + + + Sbjct: 66 NETVWNYINKHAEMMPYVN---RVKATVNGQVFSLPINLHTINQFFSKTCSPDEARALIA 122 Query: 133 EMGKEIPVDAPWQARHA-----QEWDKMTMK 158 E G D A +E + K Sbjct: 123 EKGDSTIADPQTFEEQALRFIGKELYEAFFK 153 >2CVJ-A nrPDB Length = 180 Score = 51.4 bits (121), Expect = 9e-07, Method: Composition-based stats. Identities = 29/91 (31%), Positives = 42/91 (46%), Gaps = 8/91 (8%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGP 72 M+DV ++GGG SGL+AA L+ + VLVL+ GGR+ V G P Sbjct: 1 MWDVIVVGGGPSGLSAALFLARAGLKVLVLD-----GGRSKVKGVSRVPNYP--GLLDEP 53 Query: 73 TQNRILRLSKELGIETYKVNVNERLVQYVKG 103 + +LR E Y V +V+ V+ Sbjct: 54 SGEELLRRL-EAHARRYGAEVRPGVVKGVRD 83 >3MJ4-A nrPDB Length = 397 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 28/172 (16%), Positives = 52/172 (30%), Gaps = 17/172 (9%) Query: 2 TDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVK 61 T+ FD ++G G +G A+ L+ VL+++ R +GG Y Sbjct: 18 TNTTNEQQESKGFDYLIVGAGFAGSVLAERLASSGQRVLIVDRRPHIGGNAY-------D 70 Query: 62 WVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQY-----VKGKTYPFRGAFPPVW 116 D G + P I + + E R Q+ V G+ P V Sbjct: 71 CYDDAGVLIHPYGPHIFHTNSKDVFEYLSRFTEWRPYQHRVLASVDGQLLPIPINLDTVN 130 Query: 117 N----PLAYLDYNNLWRTMDEMGKEIPVDAPWQARHA-QEWDKMTMKDLIDK 163 L + ++ E +++ ++ + K Sbjct: 131 RLYGLNLTSFQVEEFFASVAEKVEQVRTSEDVVVSKVGRDLYNKFFRGYTRK 182 >3UKH-A nrPDB Length = 519 Score = 50.6 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 79/514 (15%), Positives = 153/514 (29%), Gaps = 76/514 (14%) Query: 15 DVGLIGGGISGLAAAKLL-SEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPT 73 DV +IG G +GL AAK L + +++++ + GG T DVGG + Sbjct: 8 DVLVIGAGPTGLGAAKRLNQIDGPSWMIVDSNETPGGLASTDVTPEGFLYDVGGHVIFSH 67 Query: 74 QNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDE 133 + + E + Q + + P N ++ L + +D Sbjct: 68 Y----KYFDDCLDEALPKEDDWYTHQRISYVRCQGQWVPYPFQNNISMLPKEEQVKCIDG 123 Query: 134 MGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFA--YLFVNINVTSEPHEVSA 191 M +DA +AR T + I ++ T A F Y F V ++ Sbjct: 124 M-----IDAALEAR-VANTKPKTFDEWIVRMMGTGIADLFMRPYNFKVWAV--PTTKMQC 175 Query: 192 LWFLWYVRQCGGTARIFSVT----------NGGQERKFVGGSGQVSEQIMGLL-GDKVKL 240 W V A +V N GG+G + + L +K + Sbjct: 176 AWLGERVAAPNLKAVTTNVILGKTAGNWGPNATFRFPARGGTGGIWIAVANTLPKEKTRF 235 Query: 241 SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRL-- 298 +N V + K ++S + A+ EL QL Sbjct: 236 GEKGKVTKVNANNKTVTLQDGTTIGYKKLVSTMAVDFLAEAMNDQELVGLTKQLFYSSTH 295 Query: 299 ----------PMGAVIKCMVYYKE---AFWKKKDYCGC----MIIEDEEAPIAITLDDTK 341 P KC +Y+ E F++ + ++ P D ++ Sbjct: 296 VIGVGVRGSRPERIGDKCWLYFPEDNCPFYRATIFSNYSPYNQPEASKKLPTMQLADGSR 355 Query: 342 PDGS---LPAIMGFILARKADRQAKLHKDIRKRKIC-------------ELYAKVLGSQE 385 P + +L ++++ E+ + + Sbjct: 356 PQSTEAKEGPYWSIMLEVSESSMKPVNQETILADCIQGLVNTEMLKPTDEIVSTYHRRFD 415 Query: 386 ALYPVHYEEKNWC----------EEQYSGGCYTAYFPPGIMTQYGRVIR-QPVGRIYFAG 434 YP E+ ++ +S G + ++ + ++ + V I Sbjct: 416 HGYPTPTLEREGALTQILPKLQDKDIWSRGRFGSWRYEVGNQDHSFMLGVEAVDNIVNGA 475 Query: 435 TETATQWSGYMEGAVEAGERAAREVLNALGKVAK 468 E + ++ G + R +++ AK Sbjct: 476 VELTLNYPDFVNGR----QNTERRLVDGAQVFAK 505 >5Z70-A nrPDB Length = 605 Score = 49.8 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 73/461 (15%), Positives = 147/461 (31%), Gaps = 71/461 (15%) Query: 18 LIGGGISGLAAAKLL----SEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPT 73 +IG GI+GLA+A L ++ +L+A GG N ++ GG + Sbjct: 9 IIGSGIAGLASAFYLIRDGRMKGQDITILDAVGTPGGSLDGSGNAEDGYLIRGGREMNWN 68 Query: 74 QNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDE 133 + L +++ Y Y Y P W+ + R Sbjct: 69 YDHFWDLFQDIPALEYPS-------PYSVLDEYRAVNDNDPNWSKSRLMHKQGQIRDFST 121 Query: 134 MGKEIPVDAPWQ-----ARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHE 188 +G + W+ + ++ D +T++ + + E + ++ ++ + + Sbjct: 122 LG--LSSAHQWELIKLLLKRKEDLDDITIEQYF-----SDSFLETNFWYLWRSMFAFQNW 174 Query: 189 VSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLL---GDKVKLSSPVT 245 S L Y+ + + + K+ ++ L G V+ + V Sbjct: 175 QSLLEVKLYMHRFLDAIDGLTDMSALVFPKY-NQYDSFVVPLVNYLKGQGVNVEFGTRVY 233 Query: 246 YIDQTDDNIIVETL------NHEHYE----CKYVISAIP-----PILTAKIHFKPEL--- 287 +D TD+N + + K V+ A+ + P+L Sbjct: 234 DLDMTDNNGERTVTSILAKVDGRDQKIDIGAKDVVFALTGSMTEGTAYGDLDTAPDLTRA 293 Query: 288 --PP--------ERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITL 337 PP +N + G K + W+ C E +++ Sbjct: 294 TTPPGDSSDWALWQNLAKKSHVFGKPEKFCGQPSRSMWESATLT-CKPSPLTERLKDLSI 352 Query: 338 DDTKPDGSLPAIM------GFILARKADRQAKLHKDIRKRKICELYAKVLGSQ--EALYP 389 +D ++ + ++L+ +RQ + +YA V+ S+ L P Sbjct: 353 NDPYSGKTVTGGIITFTDSNWVLSFTCNRQPHFPTQPDDVLVLWVYALVMDSKGNHVLKP 412 Query: 390 VHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRI 430 + E + CY GI+ Q V RQ R+ Sbjct: 413 MPECTGR---EILAELCY----HLGIVDQVDEVARQTKVRL 446 >4OVI-A nrPDB Length = 542 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 29/127 (22%), Positives = 44/127 (34%), Gaps = 6/127 (4%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQ 74 DV ++G G SGL A L E +V V+E VGG + D+ + Sbjct: 18 DVLVVGAGFSGLYALYRLRELGRSVHVIETAGDVGG-VWYWNRYPGARCDI--ESIEYCY 74 Query: 75 NRILRLSKELGIETYKVNVNE--RLVQYVKGKTYPFRG-AFPPVWNPLAYLDYNNLWRTM 131 + + +E + E R + +V K G F A+ + N W Sbjct: 75 SFSEEVLQEWNWTERYASQPEILRYINFVADKFDLRSGITFHTTVTAAAFDEATNTWTVD 134 Query: 132 DEMGKEI 138 G I Sbjct: 135 TNHGDRI 141 >4REP-A nrPDB Length = 495 Score = 49.1 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 40/278 (14%), Positives = 84/278 (30%), Gaps = 20/278 (7%) Query: 31 LLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQ--NRILRLSKELGIE- 87 L +V + E D GG+ + + + + D+G + + L E I+ Sbjct: 19 RLRHQGYSVTIFEKNDYAGGKLHAIEKDGYR-FDLGPSLFTLPHLVENLFALFPEEIIDF 77 Query: 88 TYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNN---LWRTMDEMGKEIPVDAP- 143 YK + G + + + + + + + + + Sbjct: 78 GYKSKAISFHYFWDDGTLFKASTDSSQFIEDASKVFKEEKSTIKKYLAKSKSKYELTKSL 137 Query: 144 ------WQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWY 197 +A D + + T + F N +T + + Sbjct: 138 FLEKSLHKATTYFSLDTVKAIVHAPFLGLNNTLNDENSKFKNPKLTQLFNRYATYNGSSP 197 Query: 198 VRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGL---LGDKVKLSSPVTYIDQTDDNI 254 + G I + G GG ++S+ + L +G K + VT I + + + Sbjct: 198 YQTPGIMTMIPHLELGLGTYYPDGGMHRISQSLFELAQKVGVKFRFRESVTNITTSKNKV 257 Query: 255 I-VETLNHEHYECKYVISAIPPI-LTAKIHFKPELPPE 290 VET N Y V+S + + + P + Sbjct: 258 TGVETKNG-SYLSDLVVSNMDIVPTYRNLMKDVPAPEK 294 >2YQU-A nrPDB Length = 455 Score = 49.1 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 37/273 (13%), Positives = 90/273 (32%), Gaps = 25/273 (9%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGR-TYTVRNEHVKWVDVGGAYVG 71 M+D+ +IG G G AA ++ + V V+E +GG ++ Sbjct: 1 MYDLLVIGAGPGGYVAAIRAAQLGMKVGVVEKEKALGGTCLRVGCIPSKALLETTERIYE 60 Query: 72 PTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRT- 130 + + K + ++ + ++ V + F + + + + Sbjct: 61 AKKGLLGAKVKGVELDLPALMAHKDKVVQANTQGVEFLFKKNGIARHQGTARFLSERKVL 120 Query: 131 MDEMGKEIP----VDAPWQARHAQEWDKMTMKDLI---DKICWTKTAREFAYL---FVNI 180 ++E G+E+ + A A W ++ + ++ + + + + + + + + Sbjct: 121 VEETGEELEARYILIATGSAPLIPPWAQVDYERVVTSTEALSFPEVPKRLIVVGGGVIGL 180 Query: 181 NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL 240 + H + A + RI + R +E++ G ++ Sbjct: 181 ELGVVWHRLGAEVIVL-----EYMDRILPTMDLEVSR--------AAERVFKKQGLTIRT 227 Query: 241 SSPVTYIDQTDDNIIVETLNHEHYECKYVISAI 273 VT + VE E E V+ A+ Sbjct: 228 GVRVTAVVPEAKGARVELEGGEVLEADRVLVAV 260 Score = 31.7 bits (70), Expect = 0.73, Method: Composition-based stats. Identities = 13/48 (27%), Positives = 22/48 (45%) Query: 1 MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRV 48 +T E + + ++GGG+ GL + V+VLE DR+ Sbjct: 155 VTSTEALSFPEVPKRLIVVGGGVIGLELGVVWHRLGAEVIVLEYMDRI 202 >3BHF-A nrPDB Length = 390 Score = 49.1 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 42/282 (14%), Positives = 81/282 (28%), Gaps = 65/282 (23%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPT 73 FDV ++G G G+AA L++ + L+++A D G G T Sbjct: 5 FDVIVVGAGSMGMAAGYQLAKQGVKTLLVDAFD--------------PPHTNGSH-HGDT 49 Query: 74 QNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDE 133 + I + V L Y + Sbjct: 50 K-----------IIRHAYGEGREYVPLA------------LRSQELWYELEKETHHKIFT 86 Query: 134 MGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALW 193 + ++ E + + + T E + + P +A+ Sbjct: 87 KTGVLVFGPKGESAFVAETMEAAKEHSL-----TVDLLEGDEINKRWPGITVPENYNAI- 140 Query: 194 FLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDN 253 + G + N + + ++ G KV + V D + D+ Sbjct: 141 ---FEPNSG----VLFSENCIRAYR----------ELAEARGAKVLTHTRVEDFDISPDS 183 Query: 254 IIVETLNHEHYECKYVISAI---PPILTAKIHFKPELPPERN 292 + +ET N Y +I ++ L +K++ L P R Sbjct: 184 VKIETANG-SYTADKLIVSMGAWNSKLLSKLNLDIPLQPYRQ 224 >3K30-A nrPDB Length = 690 Score = 48.7 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 15/37 (40%), Positives = 22/37 (59%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRT 52 V ++G G SGL AA+ L +V++ EA +GGR Sbjct: 394 VLVVGAGPSGLEAARALGVRGYDVVLAEAGRDLGGRV 430 >4Y4M-A nrPDB Length = 290 Score = 47.9 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 13/29 (44%), Positives = 19/29 (65%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLE 43 DV ++G G SGL A+ L++ V+VLE Sbjct: 61 DVVIVGAGPSGLTCARYLAKEGFKVVVLE 89 >3LXD-A nrPDB Length = 415 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 18/47 (38%), Positives = 26/47 (55%) Query: 7 PNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTY 53 L + +IGGG GL AA +L+++ +NV +LEA RV R Sbjct: 146 AELDAGAKNAVVIGGGYIGLEAAAVLTKFGVNVTLLEALPRVLARVA 192 >1NAA-A nrPDB Length = 541 Score = 46.4 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 21/73 (28%), Positives = 31/73 (42%), Gaps = 6/73 (8%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGP 72 +D ++G G G+ AA LSE VL+LE GG + + +V G Sbjct: 2 PYDYIIVGAGPGGIIAADRLSEAGKKVLLLER----GGP--STKQTGGTYVAPWATSSGL 55 Query: 73 TQNRILRLSKELG 85 T+ I L + L Sbjct: 56 TKFDIPGLFESLF 68 >4Y4N-A nrPDB Length = 286 Score = 46.4 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 14/29 (48%), Positives = 21/29 (72%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLE 43 DV ++GGG SGL AA+ +++ V+VLE Sbjct: 54 DVAIVGGGPSGLTAARYIAKEGYKVVVLE 82 >5MJK-A nrPDB Length = 327 Score = 45.6 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 21/78 (26%), Positives = 38/78 (48%), Gaps = 6/78 (7%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRT-YTVRNEHVKWVDVGGAYVGP 72 +DV +IG G +G+ AA + ++ L+LE R GG+ T E+ + +GP Sbjct: 25 YDVVIIGSGPAGMTAAMYTARSEMKTLLLE-RGVPGGQMNNTAEIENYPGYET---IMGP 80 Query: 73 TQN-RILRLSKELGIETY 89 + ++ + LG+E Sbjct: 81 ELSMKMAEPLEGLGVENA 98 Score = 31.7 bits (70), Expect = 0.80, Method: Composition-based stats. Identities = 10/34 (29%), Positives = 21/34 (61%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRV 48 ++ +IGGG S + A L+ + +V ++ RD++ Sbjct: 165 EILVIGGGDSAVEEALYLTRFGQSVTIMHRRDKL 198 >3AB1-A nrPDB Length = 360 Score = 45.6 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 47/279 (16%), Positives = 96/279 (34%), Gaps = 26/279 (9%) Query: 1 MTDLEKPNLAGH-MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEH 59 M D+ P H M D+ +IGGG +G+ AA I+ ++E+ ++GG+ + E Sbjct: 1 MLDIHNPATDHHDMRDLTIIGGGPTGIFAAFQCGMNNISCRIIESMPQLGGQLAALYPEK 60 Query: 60 VKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPL 119 DV G P I L + L + + N + L + V T G F N Sbjct: 61 -HIYDVAG---FPEVPAI-DLVESLWAQAERYNPDVVLNETVTKYTKLDDGTFETRTNTG 115 Query: 120 AYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVN 179 + + P + D +T + + + + + V Sbjct: 116 NVY-----RSRAVLIAAGLGAFEPRKLPQLGNIDHLTGSSVYYAVKSVEDFKGKRVVIVG 170 Query: 180 INVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVK 239 + + W + ++ ++ + G E + G + E+ V Sbjct: 171 G------GDSALDWTVGLIKNAASV----TLVHRGHEFQGHGKTAHEVERARANGTIDVY 220 Query: 240 LSSPVTYIDQTDDNII---VETLNHE--HYECKYVISAI 273 L + V I++++ + + + + E ++ I Sbjct: 221 LETEVASIEESNGVLTRVHLRSSDGSKWTVEADRLLILI 259 >5VJ7-A nrPDB Length = 476 Score = 45.2 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 19/35 (54%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 V +IG G +GL A L++ V + EA + GG Sbjct: 157 VAIIGAGPAGLTCAADLAKMGYEVTIYEALHQPGG 191 >5JFC-L nrPDB Length = 474 Score = 45.2 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 19/35 (54%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 V +IG G +GL A L++ V + EA + GG Sbjct: 157 VAIIGAGPAGLTCAADLAKMGYEVTIYEALHQPGG 191 >3UP5-A nrPDB Length = 545 Score = 44.8 bits (104), Expect = 9e-05, Method: Composition-based stats. Identities = 15/43 (34%), Positives = 26/43 (60%), Gaps = 1/43 (2%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVR 56 D +IG G++G+ A L+++ + VL +EA + VGG T+ Sbjct: 10 LDAVVIGAGVTGIYQAFLINQAGMKVLGIEAGEDVGG-TWYWN 51 >2UZZ-A nrPDB Length = 372 Score = 44.8 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 20/102 (19%), Positives = 32/102 (31%), Gaps = 2/102 (1%) Query: 229 QIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELP 288 Q+ G + PVT I DD + +ET + E Y+ K I + + P P Sbjct: 157 QLAKEAGCAQLFNCPVTAIRHDDDGVTIETADGE-YQAKKAIVCAGTWVKDLLPELPVQP 215 Query: 289 PERNQLIQRLPMGAVIK-CMVYYKEAFWKKKDYCGCMIIEDE 329 + + +K + Y G D Sbjct: 216 VRKVFAWYQADGRYSVKNKFPAFTGELPNGDQYYGFPAENDA 257 Score = 34.0 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 11/31 (35%), Positives = 18/31 (58%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEA 44 +D+ +IG G G AA + +NVL+ +A Sbjct: 3 YDLIIIGSGSVGAAAGYYATRAGLNVLMTDA 33 >6JDK-A nrPDB Length = 544 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 18/110 (16%), Positives = 33/110 (30%), Gaps = 3/110 (2%) Query: 2 TDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVK 61 + + N +FD ++G G +G+ L + V + EA +GG + Sbjct: 6 SSQTQKNDDAEVFDALIVGAGFNGIYQLHRLRQEGFKVRLFEAGADMGG-IWYWNCYPGA 64 Query: 62 WVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGA 111 VD + + R E + R + K Sbjct: 65 RVDSHIPIYEFSIEELWRDWN--WTERFPAWDELRRYFHYVDKKLDLSRD 112 >3ATQ-A nrPDB Length = 453 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 14/40 (35%), Positives = 28/40 (70%), Gaps = 2/40 (5%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEAR--DRVGGR 51 +DV +IGGG +G +AA LS + +L+++++ +R+G + Sbjct: 7 YDVLIIGGGFAGSSAAYQLSRRGLKILLVDSKPWNRIGDK 46 >4UIR-A nrPDB Length = 646 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 42/278 (15%), Positives = 90/278 (32%), Gaps = 36/278 (12%) Query: 18 LIGGGISGLAAAKLLSEYKI----NVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPT 73 +IG GI+G++AA N+ LE GG N ++ GG + T Sbjct: 67 IIGSGIAGMSAAYYFIRDGHVPAKNITFLEQLHIDGGSLDGAGNPTDGYIIRGGREMDMT 126 Query: 74 QNRILRLSKE---LGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNL-WR 129 + + ++ L + ++E + Y + N D++ Sbjct: 127 YENLWDMFQDIPALEMPAPYSVLDEYRLINDNDSNYSKAR---LINNKGEIKDFSKFGLN 183 Query: 130 TMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREF---AYLFVNINVTSEP 186 MD++ ++ +E D +T++D + F + F N + E Sbjct: 184 KMDQLA-----IIRLLLKNKEELDDLTIEDYFSESFLKSNFWTFWRTMFAFENWHSLLEL 238 Query: 187 HEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTY 246 ++ FL + + + + + + G + L++ V Sbjct: 239 -KLYMHRFLHAIDGLNDLSSLVFPKYNQYDTFVTP-----LRKFLQEKGVNIHLNTLVKD 292 Query: 247 ID---QTDDNI---IVETLNHEHYEC-----KYVISAI 273 +D T+ + I+ + + + YVI Sbjct: 293 LDIHINTEGKVVEGIITEQDGKEVKIPVGKNDYVIVTT 330 >3URH-A nrPDB Length = 491 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 41/278 (14%), Positives = 87/278 (31%), Gaps = 25/278 (8%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPT 73 +D+ +IG G G A ++ + V V+E R GG V K + Sbjct: 26 YDLIVIGSGPGGYVCAIKAAQLGMKVAVVEKRSTYGGTCLNVGCIPSKALLHASEMFHQA 85 Query: 74 QNRILRL-----SKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLW 128 Q+ + L + +L ++ + + + V G ++ F+ + + Sbjct: 86 QHGLEALGVEVANPKLNLQKMMAHKDATVKSNVDGVSFLFKKNKIDGFQGTGKVLGQGKV 145 Query: 129 RTMDEMGKEIPVDAP----WQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTS 184 +E G+E ++A + + D+ + A V ++ Sbjct: 146 SVTNEKGEEQVLEAKNVVIATGSDVAGIPGVEVA--FDEKTIVSSTGALALEKVPASMIV 203 Query: 185 EPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSG----QVSEQIMGLLGDKVKL 240 V L + G + + GG + ++++ G KL Sbjct: 204 VGGGVIGLELGSVWARLGAKVTVVEFLDTIL-----GGMDGEVAKQLQRMLTKQGIDFKL 258 Query: 241 SSPVTYIDQTDDNIIVETL-----NHEHYECKYVISAI 273 + VT ++ D V + + V+ A Sbjct: 259 GAKVTGAVKSGDGAKVTFEPVKGGEATTLDAEVVLIAT 296 Score = 29.0 bits (63), Expect = 5.4, Method: Composition-based stats. Identities = 11/39 (28%), Positives = 19/39 (48%), Gaps = 1/39 (2%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRV-GG 50 + ++GGG+ GL + + V V+E D + GG Sbjct: 198 PASMIVVGGGVIGLELGSVWARLGAKVTVVEFLDTILGG 236 >4YRY-B nrPDB Length = 468 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 21/35 (60%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 V ++G G +GL AA L++ +V + EA + GG Sbjct: 143 VAVVGSGPAGLTAAADLAKMGYHVDIFEAFHKPGG 177 >4AP1-A nrPDB Length = 549 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 16/52 (30%), Positives = 22/52 (42%), Gaps = 1/52 (1%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDV 65 +DV ++G GI+GL A + V EA VGG + DV Sbjct: 22 YDVVVVGAGIAGLYAIHRFRSQGLTVRAFEAASGVGG-VWYWNRYPGARCDV 72 >4C5O-A nrPDB Length = 357 Score = 44.0 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 15/36 (41%), Positives = 22/36 (61%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 DV +IGGG SGL+A L ++ ++L+A GG Sbjct: 5 DVVVIGGGQSGLSAGYFLRRSGLSYVILDAEASPGG 40 >2Q7V-A nrPDB Length = 325 Score = 44.0 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 24/100 (24%), Positives = 47/100 (47%), Gaps = 4/100 (4%) Query: 11 GHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRT-YTVRNEHVKWVDVGGAY 69 H +DV +IGGG +GL AA +++ L+LE + GG+ ++ E+ A Sbjct: 6 AHDYDVVIIGGGPAGLTAAIYTGRAQLSTLILE-KGMPGGQIAWSEEVENFPGFPEPIAG 64 Query: 70 VGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFR 109 + Q R+ + +++ G +++ + + YPF Sbjct: 65 MELAQ-RMHQQAEKFG-AKVEMDEVQGVQHDATSHPYPFT 102 >3RP7-A nrPDB Length = 407 Score = 44.0 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 16/34 (47%), Positives = 20/34 (58%), Gaps = 1/34 (2%) Query: 11 GHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEA 44 GHM +IG GI GL+AA L + I+ V EA Sbjct: 22 GHM-KAIVIGAGIGGLSAAVALKQSGIDCDVYEA 54 >2VHY-A nrPDB Length = 377 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 34/190 (17%), Positives = 67/190 (35%), Gaps = 21/190 (11%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEAR-DRVG-------GRTYTVRNEHVKW-- 62 DV +IG G +G AA++ + V VL+ D++ GR +T + + Sbjct: 168 PADVVVIGAGTAGYNAARIANGMGATVTVLDINIDKLRQLDAEFCGRIHTRYSSAYELEG 227 Query: 63 ------VDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVW 116 + +G V + L +S L + LV + F G+ P + Sbjct: 228 AVKRADLVIGAVLVPGAKAPKL-VSNSL---VAHMKPGAVLVDIAIDQGGCFEGSRPTTY 283 Query: 117 NPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDL-IDKICWTKTAREFAY 175 + + ++ L+ + M +P + + +A + + D C + A Sbjct: 284 DHPTFAVHDTLFYCVANMPASVPKTSTYALTNATMPYVLELADHGWRAACRSNPALAKGL 343 Query: 176 LFVNINVTSE 185 + SE Sbjct: 344 STHEGALLSE 353 >2GAG-B nrPDB Length = 405 Score = 43.3 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 39/170 (22%), Positives = 58/170 (34%), Gaps = 45/170 (26%) Query: 14 FDVGLIGGGISGLAAAKLL-SEYKI-NVLVLEARDRVGG---RTYTVRNEHVKWVDVGGA 68 +D ++GGG GLA A L + I NV VLE GG R T+ + W + G Sbjct: 22 YDAIIVGGGGHGLATAYFLAKNHGITNVAVLEKGWLAGGNMARNTTIIRSNYLWDESAGI 81 Query: 69 Y-----------------VGPTQNRILRLSKELG---------------------IETYK 90 Y +Q +L L+ LG ++ + Sbjct: 82 YEKSLKLWEQLPEDLEYDFLFSQRGVLNLAHTLGDVRESVRRVEANKLNGVDAEWLDPSQ 141 Query: 91 VNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYN--NLWRTMDEMGKEI 138 V ++ YP GA +A D+ R +EMG +I Sbjct: 142 VKEACPIINTSDDIRYPVMGATWQPRAGIAKHDHVAWAFARKANEMGVDI 191 >1V59-A nrPDB Length = 478 Score = 43.3 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 44/283 (15%), Positives = 90/283 (31%), Gaps = 30/283 (10%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQ 74 DV +IGGG +G AA ++ N +E R ++GG T N Sbjct: 7 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG---TCLNVGCIPSKALLNNSHL-F 62 Query: 75 NRILRLSKELGIETYK-VNVNERLVQYVKGKTYPFRGAFPPVW---NPLAYLDYNNLWRT 130 +++ +++ GI+ + +N Q K + N + Y N + Sbjct: 63 HQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFE- 121 Query: 131 MDEMGKEIPVDAPWQAR-------HAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVT 183 DE + + + T ++ + +++ Sbjct: 122 -DETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLK 180 Query: 184 SEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERK------FVGGSGQVSEQIMGLLGDK 237 P ++ + + G E + G + +++ + G Sbjct: 181 EIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLD 240 Query: 238 VKLSSPVTYIDQTDDNIIVE-------TLNHEHYECKYVISAI 273 KLS+ V + DD +VE T E+ E + ++ A+ Sbjct: 241 FKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAV 283 >6BRD-A nrPDB Length = 476 Score = 43.3 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 16/31 (51%), Positives = 21/31 (67%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLE 43 MFDV ++GGG +GL A L + + VLVLE Sbjct: 1 MFDVIVVGGGPTGLMLAGELRLHGVRVLVLE 31 Score = 38.3 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 35/230 (15%), Positives = 68/230 (29%), Gaps = 56/230 (24%) Query: 223 SGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAK-- 280 + Q+ + LG +++ + + Q +D + V+ + E +YV+ T + Sbjct: 101 TEQLLAEHATALGAEIRRGRALVGLRQDEDGVTVDLADGEQLRARYVVGCDGGRSTVRKL 160 Query: 281 --IHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLD 338 + F P P L+ + M A + + K + G M + D + Sbjct: 161 LGVAF-PGEPSRVETLLGEMEMTASQEELTSVMTEVRKTQQRFGAMPLGDGVFRV----- 214 Query: 339 DTKPDGSLPAIMGFILARKA--DRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKN 396 + A DR A D K+++ G Sbjct: 215 -------------VVPAEGVAEDRTASPTLDEFKQQLRAHAGTDFGVHS----------- 250 Query: 397 WCEEQYSGGCYTAYFPPGIMTQYGRVIRQP----VGRIYFAGTETATQWS 442 P ++++G RQ V R++ AG Sbjct: 251 ----------------PRWLSRFGDATRQAERYRVDRVFLAGDAAHIHPP 284 >1ZOV-A nrPDB Length = 386 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 38/282 (13%), Positives = 81/282 (28%), Gaps = 65/282 (23%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPT 73 FDV ++G G G+AA L++ + L++ + G++ G Sbjct: 4 FDVIVVGAGSMGMAAGYYLAKQGVKTLLV---------------DSFDPPHTNGSHHG-- 46 Query: 74 QNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDE 133 + R++++ G+ + F L Y + Sbjct: 47 --------------------DTRIIRHAYGEGREYV-PFALRAQELWYELEKETHHKIFT 85 Query: 134 MGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALW 193 + + E + ++ E L P A+ Sbjct: 86 QTGVLVYGPKGGSAFVSETMEAANIHSLEH-----ELFEGKQLTDRWAGVEVPDNYEAI- 139 Query: 194 FLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDN 253 + G + N Q + ++ G V +PV + T+D Sbjct: 140 ---FEPNSG----VLFSENCIQAYR----------ELAEAHGATVLTYTPVEDFEVTEDL 182 Query: 254 IIVETLNHEHYECKYVISAI---PPILTAKIHFKPELPPERN 292 + ++T Y ++ ++ L +K+ + L P R Sbjct: 183 VTIKTAKG-SYTANKLVVSMGAWNSKLLSKLDVEIPLQPYRQ 223 >3JSK-A nrPDB Length = 344 Score = 42.5 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 3/56 (5%) Query: 1 MTDLEKPNLAGHM-FDVGLIGGGISGLAAAKLLSEY--KINVLVLEARDRVGGRTY 53 MT +L H D+ ++G G GL+AA +LS + + ++EA GG + Sbjct: 66 MTRRYFADLDAHAETDIVIVGAGSCGLSAAYVLSTLRPDLRITIVEAGVAPGGGAW 121 >2VOU-A nrPDB Length = 397 Score = 42.5 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 25/106 (23%), Positives = 43/106 (40%), Gaps = 15/106 (14%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQN 75 + ++GG ISGL AA +L + ++V V E + + V Q Sbjct: 8 IAVVGGSISGLTAALMLRDAGVDVDVYERSPQP------LSGFGTGIV---------VQP 52 Query: 76 RILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAY 121 ++ E G+E ++V ++YV T G+ P W +Y Sbjct: 53 ELVHYLLEQGVELDSISVPSSSMEYVDALTGERVGSVPADWRFTSY 98 >3FPZ-A nrPDB Length = 326 Score = 42.5 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 28/161 (17%), Positives = 56/161 (34%), Gaps = 22/161 (13%) Query: 15 DVGLIGGGISGLAAAKLLSEY--KINVLVLEARDRVGGRTY----------------TVR 56 DV ++G G SGL+AA ++++ + V ++E+ GG ++ Sbjct: 67 DVIIVGAGSSGLSAAYVIAKNRPDLKVCIIESSVAPGGGSWLGGQLFSAMVMRKPAHLFL 126 Query: 57 NEHVKWVDVGGAYVGPTQNRIL---RLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFP 113 E + G YV + LSK L + K+ N V+ + + +G Sbjct: 127 QELEIPYEDEGDYVVVKHAALFISTVLSKVLQLPNVKL-FNATCVEDLVTRPPTEKGEVT 185 Query: 114 PVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDK 154 + T M + A ++ ++ + Sbjct: 186 VAGVVTNWTLVTQAHGTQCSMDPNVIELAGYKNDGTRDLSQ 226 >1UKV-G nrPDB Length = 453 Score = 42.1 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 50/304 (16%), Positives = 94/304 (30%), Gaps = 50/304 (16%) Query: 3 DLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV-- 60 D E + +DV ++G GI+ + LLS VL ++ +D GG +V + Sbjct: 4 DQETIDTD---YDVIVLGTGITECILSGLLSVDGKKVLHIDKQDHYGGEAASVTLSQLYE 60 Query: 61 --------------------KWVDVGGAYVGPTQNRILRLSKELGIETY-KVNVNERLVQ 99 W + + + Y Sbjct: 61 KFKQNPISKEERESKFGKDRDWNVDLIPKFLMANGELTNILIHTDVTRYVDFKQVSGSYV 120 Query: 100 YVKGKTYPFRGAF-PPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMK 158 + +GK Y + +PL + + E D + + DK TM Sbjct: 121 FKQGKIYKVPANEIEAISSPLMGIFEKRRMKKFLEWISSYKEDDLSTHQGL-DLDKNTMD 179 Query: 159 DLIDKICWTKTAREFAY----LFVNINVTSEPHEVSALWFLWY---VRQCGGTARIFSVT 211 ++ K + +EF L+ N + +P S L Y V + G + ++ + Sbjct: 180 EVYYKFGLGNSTKEFIGHAMALWTNDDYLQQPARPSFERILLYCQSVARYGKSPYLYPMY 239 Query: 212 NGGQERKFVGGSGQVSEQIMGL---LGDKVKLSSPVTYIDQTDDNIIVETLNHE--HYEC 266 G G++ + L G L +P+ + D E + + ++ Sbjct: 240 ----------GLGELPQGFARLSAIYGGTYMLDTPIDEVLYKKDTGKFEGVKTKLGTFKA 289 Query: 267 KYVI 270 VI Sbjct: 290 PLVI 293 >5TUF-A nrPDB Length = 409 Score = 42.1 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 38/235 (16%), Positives = 79/235 (33%), Gaps = 19/235 (8%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLE--ARDRVGGRTYTVRNEHVKWVDVGGAYVGPT 73 + +IG G++G A A L + + +++E A R GG+ +R G Y Sbjct: 28 ILVIGVGVAGPAVAYWLKRFGFSPVLIEKSAAVRKGGQALDIRGIATHIAKEMGIYDQIC 87 Query: 74 QNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPP--VWNPLAYLDYNNLWRTM 131 R V+V ++ +G+T+ FR + L + + Sbjct: 88 NMRTQIKCGRY------VDVKGNVLHEEQGETFGFRQDDEVEILRGDLVEILMKAIADIP 141 Query: 132 DEMGK--------EIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVT 183 E + E V ++ + +D + D I + Y +N+ Sbjct: 142 CEFKQSVIKIEQNEDSVTVTYKDGRVENYDLVIAADGIHSATRGMVFSKNEYQLINLGSY 201 Query: 184 SEPHEVS-ALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDK 237 + L C ++ ++ + Q K + G S+ ++ + D+ Sbjct: 202 VSAFTIPNYLGLDHMELLCESNHKLVTLQSDSQADKAMAGFMFRSKHVLEDIRDE 256 Score = 35.2 bits (79), Expect = 0.069, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 22/50 (44%), Gaps = 1/50 (2%) Query: 224 GQVSEQIMGLLGD-KVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISA 272 G + E +M + D + V I+Q +D++ V + VI+A Sbjct: 127 GDLVEILMKAIADIPCEFKQSVIKIEQNEDSVTVTYKDGRVENYDLVIAA 176 >3LZX-A nrPDB Length = 332 Score = 41.7 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 28/155 (18%), Positives = 57/155 (36%), Gaps = 9/155 (5%) Query: 10 AGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAY 69 ++D+ +IGGG GL A + +V ++E+ ++GG+ + E + G Sbjct: 4 DTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGGQLSALYPEKYIYDVAGFPK 63 Query: 70 VGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWR 129 + R L L + K + L Q V+ G F V N + + Sbjct: 64 I-----RAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFKLVTNEETHYSKTVII- 117 Query: 130 TMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKI 164 G + +A++++ + +D + Sbjct: 118 ---TAGNGAFKPRKLELENAEQYEGKNLHYFVDDL 149 >1DOD-A nrPDB Length = 394 Score = 41.7 bits (96), Expect = 8e-04, Method: Composition-based stats. Identities = 17/49 (34%), Positives = 24/49 (48%), Gaps = 2/49 (4%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEAR--DRVGGRTYTVRNEHVK 61 V +IG G SGL +LL + I+ ++LE + D V GR E Sbjct: 4 QVAIIGAGPSGLLLGQLLHKAGIDNVILERQTPDYVLGRIRAGVLEQGM 52 >3P1W-A nrPDB Length = 475 Score = 41.3 bits (95), Expect = 9e-04, Method: Composition-based stats. Identities = 50/297 (16%), Positives = 96/297 (32%), Gaps = 42/297 (14%) Query: 11 GHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVR-------------- 56 G +DV ++G G+ + LLS Y +LVL+ GG T ++ Sbjct: 18 GEHYDVIILGTGLKECILSGLLSHYGKKILVLDRNPYYGGETASLNLTNLYNTFKPKENI 77 Query: 57 ----NEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNV-NERLVQYVKGKTYPFRGA 111 E+ W ++++ K+ + Y + E Y K Sbjct: 78 PSKYGENRHWNVDLIPKFILVGGNLVKILKKTRVTNYLEWLVVEGSYVYQHQKKGFLTSE 137 Query: 112 FPPVWNPLAYLDYNNLWRTMDEMGKE------IPVDAPWQARHAQEWD-----KMTMKDL 160 P D L + + ++ + W A WD K+TM ++ Sbjct: 138 KFIHKVPAT--DMEALVSPLLSLMEKNRCKNFYQYVSEWDANKRNTWDNLDPYKLTMLEI 195 Query: 161 IDKICWTKTAREFAY----LFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQE 216 + +F L++N + +P ++ Y++ F + Sbjct: 196 YKHFNLCQLTIDFLGHAVALYLNDDYLKQPAYLTLERIKLYMQSISA----FGKSPFIYP 251 Query: 217 RKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDN--IIVETLNHEHYECKYVIS 271 +GG + ++ + G L+ V DDN +++ + E C VI Sbjct: 252 LYGLGGIPEGFSRMCAINGGTFMLNKNVVDFVFDDDNKVCGIKSSDGEIAYCDKVIC 308 >5TWC-A nrPDB Length = 344 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 26/87 (29%), Positives = 44/87 (50%), Gaps = 2/87 (2%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGP 72 M DV +IGGG SGL A+ ++V +++ + +GG+ E + W D+GG P Sbjct: 1 MKDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRIYP-EKIIW-DIGGIAPKP 58 Query: 73 TQNRILRLSKELGIETYKVNVNERLVQ 99 + K+ +V++NER+V Sbjct: 59 CHEILKDTIKQGLYFKPEVHLNERVVD 85 >3IHG-A nrPDB Length = 535 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 14/34 (41%), Positives = 21/34 (61%) Query: 12 HMFDVGLIGGGISGLAAAKLLSEYKINVLVLEAR 45 H DV ++G G+ GL+ A L+ + VLV+E R Sbjct: 4 HEVDVLVVGAGLGGLSTAMFLARQGVRVLVVERR 37 >4GCM-A nrPDB Length = 312 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 15/53 (28%), Positives = 27/53 (50%), Gaps = 2/53 (3%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTY-TVRNEHVKWVDV 65 FD+ +IG G +G+ AA S + +++E R GG+ T E+ ++ Sbjct: 7 FDIAIIGAGPAGMTAAVYASRANLKTVMIE-RGIPGGQMANTEEVENFPGFEM 58 >4K22-A nrPDB Length = 365 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 15/31 (48%), Positives = 19/31 (61%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEAR 45 DV ++GGG+ GLA A L + V VLE R Sbjct: 5 DVAIVGGGMVGLAVACGLQGSGLRVAVLEQR 35 >4ZN0-A nrPDB Length = 311 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 15/40 (37%), Positives = 25/40 (62%), Gaps = 1/40 (2%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRT 52 M+D+ +IGGG +GL A Y ++ L+LE R+ + G+ Sbjct: 7 MYDLIIIGGGPAGLTAGIYAVRYGLDTLILE-RNEISGQI 45 Score = 30.6 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 13/51 (25%), Positives = 24/51 (47%), Gaps = 1/51 (1%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRV-GGRTYTVRNEHVKWVDV 65 V ++GGG S + A LS+ V ++ RD + R R + +++ Sbjct: 149 VAVVGGGNSAVTDALFLSKVAQKVYLVHRRDHLKAARVLQDRVDGTPNIEL 199 >1RP0-A nrPDB Length = 284 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 13/40 (32%), Positives = 23/40 (57%), Gaps = 1/40 (2%) Query: 15 DVGLIGGGISGLAAAKLLSEY-KINVLVLEARDRVGGRTY 53 DV ++G G +GL+AA +S+ + V ++E GG + Sbjct: 41 DVVVVGAGSAGLSAAYEISKNPNVQVAIIEQSVSPGGGAW 80 >4C3X-A nrPDB Length = 530 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 13/36 (36%), Positives = 18/36 (50%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 DV ++G G L A + + +VLE DR GG Sbjct: 29 DVLVVGSGGGALTGAYTAAAQGLTTIVLEKTDRFGG 64 >6N7F-A nrPDB Length = 453 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 13/38 (34%), Positives = 24/38 (63%), Gaps = 1/38 (2%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 +D +IGGG +G+A+A + + VL+ E ++ +GG Sbjct: 7 PYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKE-IGG 43 >4A6N-B nrPDB Length = 398 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 17/32 (53%), Positives = 21/32 (65%), Gaps = 1/32 (3%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARD 46 +V +IGGG GL AKLL + I+V V E RD Sbjct: 28 NVAIIGGGPVGLTMAKLLQQNGIDVSVYE-RD 58 >3R9U-A nrPDB Length = 315 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 1/53 (1%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGR-TYTVRNEHVKWVD 64 M DV +IGGG +GL+A + + +V+ + GG+ T + E+ V Sbjct: 4 MLDVAIIGGGPAGLSAGLYATRGGLKNVVMFEKGMPGGQITSSSEIENYPGVA 56 >6C87-A nrPDB Length = 452 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 42/295 (14%), Positives = 88/295 (29%), Gaps = 30/295 (10%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV----------KWV 63 +DV ++G G++ + LLS VL ++ GG + ++ + + Sbjct: 13 YDVVVLGTGLTECVISGLLSVSGKKVLHMDRNPYYGGESASLNLDQMFEKFRGQDAKPPA 72 Query: 64 DVGGAY---------VGPTQNRILRLSKELGIETYKVNV--NERLVQYVKGKTYPFR-GA 111 +G + +++++ + G+ Y + E Y KG+ + Sbjct: 73 SLGRSRDYNIDLIPKFLMANGKLVKILRMTGVTRYNMEFALVEGSFVYHKGEIHKVPITP 132 Query: 112 FPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAR 171 PL + + + + P + + K TM + ++ Sbjct: 133 TEVAKTPLLGFFEKLKAKKLVSYLYDYDQNNPKTHQGF-DCSKDTMDKIYKYYGVSEDTT 191 Query: 172 EFAYLFVN-INVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQI 230 +F V S V AL + R + G G++ + Sbjct: 192 DFLGHAVALYTDDSYMTTVPALEVI--ERMRLYEDSLNMYGKSPYVYPMY-GLGELPQVF 248 Query: 231 MGLL---GDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIH 282 L G L V I D+ +V + ++ P K+ Sbjct: 249 ARLCAVYGGTYMLDKKVDRIVYDDNGHVVGVESGGEVAKCKMVVGDPSYFPEKVR 303 >5KOX-A nrPDB Length = 476 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 14/32 (43%), Positives = 19/32 (59%) Query: 12 HMFDVGLIGGGISGLAAAKLLSEYKINVLVLE 43 HM DV + GGG +GL A L + + +VLE Sbjct: 3 HMIDVIIAGGGPTGLMLAGELRLHGVRTVVLE 34 Score = 35.2 bits (79), Expect = 0.067, Method: Composition-based stats. Identities = 8/50 (16%), Positives = 21/50 (42%) Query: 223 SGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISA 272 + ++ + LG +++ V +DQ D + E + +Y++ Sbjct: 104 TERLLTEHATELGAEIRRGCEVAGLDQDADGVTAELADGTRLRARYLVGC 153 >5UTH-A nrPDB Length = 319 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 15/54 (27%), Positives = 22/54 (40%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVG 66 + DV +IG G +G AA + ++ LV E G T E+ G Sbjct: 15 VHDVIIIGSGPAGYTAAIYAARAQLKPLVFEGTQFGGALMTTTEVENYPGFREG 68 Score = 31.7 bits (70), Expect = 0.87, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 19/32 (59%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARD 46 D+ ++GGG S + A L+ + +V ++ RD Sbjct: 157 DIVVVGGGDSAMEEATFLTRFARSVTLIHRRD 188 >2RGJ-A nrPDB Length = 402 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 12/37 (32%), Positives = 19/37 (51%), Gaps = 1/37 (2%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKI-NVLVLEARDRV 48 D+ + G GI GL+ A L + I V +LE+ + Sbjct: 4 PIDILIAGAGIGGLSCALALHQAGIGKVTLLESSSEI 40 >1NHQ-A nrPDB Length = 447 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 13/47 (27%), Positives = 25/47 (53%) Query: 4 LEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 L++ + + +V +IG G G+ AA+ ++ V V++ DR G Sbjct: 140 LKQKTVDPEVNNVVVIGSGYIGIEAAEAFAKAGKKVTVIDILDRPLG 186 >5UWY-A nrPDB Length = 308 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 15/53 (28%), Positives = 27/53 (50%), Gaps = 2/53 (3%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRT-YTVRNEHVKWVD 64 M+D +IG G +G+ AA + ++V ++E + GG+ T E+ D Sbjct: 4 MYDTLIIGSGPAGMTAALYAARSNLSVAIIE-QGAPGGQMNNTFDIENYPGYD 55 Score = 31.7 bits (70), Expect = 0.79, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 21/34 (61%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRV 48 D+ ++GGG S + A L+++ V V+ RD++ Sbjct: 145 DLLVVGGGDSAVEEAIYLTQFAKKVTVVHRRDQL 178 >3CP8-A nrPDB Length = 641 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 23/129 (17%), Positives = 45/129 (34%), Gaps = 7/129 (5%) Query: 12 HMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVG 71 HM+DV ++G G +G AA ++ ++ L++ + R +GG G Sbjct: 20 HMYDVIVVGAGHAGCEAALAVARGGLHCLLITSDLSAVARMSCNP-------AIGGVAKG 72 Query: 72 PTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTM 131 I L E+G + R++ KG A Y+ Sbjct: 73 QITREIDALGGEMGKAIDATGIQFRMLNRSKGPAMHSPRAQADKTQYSLYMRRIVEHEPN 132 Query: 132 DEMGKEIPV 140 ++ ++ + Sbjct: 133 IDLLQDTVI 141 >1GPE-A nrPDB Length = 587 Score = 39.4 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 19/42 (45%), Positives = 26/42 (61%), Gaps = 2/42 (4%) Query: 4 LEKPNL-AGHMFDVGLIGGGISGLAAAKLLSEY-KINVLVLE 43 L P+ AG +D + GGG++GL A L+E KI VLV+E Sbjct: 14 LSDPSKVAGKTYDYIIAGGGLTGLTVAAKLTENPKIKVLVIE 55 >2TMD-A nrPDB Length = 729 Score = 39.4 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 21/35 (60%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 V ++G G SG AA++L E V + + +++GG Sbjct: 392 VLIVGAGPSGSEAARVLMESGYTVHLTDTAEKIGG 426 >5J5Z-A nrPDB Length = 496 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 43/274 (15%), Positives = 84/274 (30%), Gaps = 18/274 (6%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQ 74 DV +IG G G AA ++ + +E + +GG V K + Y Sbjct: 30 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 89 Query: 75 NRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEM 134 + GIE +V +N + K + + N + + Sbjct: 90 GKDF---ASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK 146 Query: 135 GKEIPVDAPWQAR--HAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSAL 192 + A + + T ++ T +++ P ++ + Sbjct: 147 NQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVI 206 Query: 193 WFLWYVRQCGGTARIFSVTNGGQERK-FVGGSG------QVSEQIMGLLGDKVKLSSPVT 245 + G + E VGG G + ++I+ G K KL++ VT Sbjct: 207 GAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVT 266 Query: 246 YIDQTDDN---IIVETLNH---EHYECKYVISAI 273 + D + +E + E C ++ I Sbjct: 267 GATKKSDGKIDVSIEAASGGKAEVITCDVLLVCI 300 >3CGD-A nrPDB Length = 480 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 41/276 (14%), Positives = 87/276 (31%), Gaps = 25/276 (9%) Query: 1 MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLL--SEYKINVLVLEARDRVGGRTYTVRNE 58 + D + + G M + +IGG +G++AA + ++ NV+ LE G Y+ Sbjct: 25 LYDDDDKDRWGSM-NYVIIGGDAAGMSAAMQIVRNDENANVVTLEK-----GEIYSYAQC 78 Query: 59 HVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNP 118 + +V G + T+ I R K + Y ++ R A Sbjct: 79 GLPYVISGA--IASTEKLIARNVKTFR-DKYGIDAKVRHEVTKVDTEKKIVYAEHTKTKD 135 Query: 119 LAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKM-TMKDLIDKICWTKTAREFAYLF 177 + Y+ L PV W+ R Q + T+ D + +T + Sbjct: 136 VFEFSYDRLLIATGVR----PVMPEWEGRDLQGVHLLKTIPDAERILKTLETNKVEDVTI 191 Query: 178 VNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDK 237 + + + VR I ++ + G + + + Sbjct: 192 IGGGAIGLEMAETFVELGKKVRMIERNDHIGTI--------YDGDMAEYIYKEADKHHIE 243 Query: 238 VKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAI 273 + + V + + + Y+ V+ ++ Sbjct: 244 ILTNENVKAFKGN-ERVEAVETDKGTYKADLVLVSV 278 >2A87-A nrPDB Length = 335 Score = 39.0 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 17/60 (28%), Positives = 24/60 (40%), Gaps = 1/60 (1%) Query: 8 NLAGHMF-DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVG 66 + A H DV +IG G +G AA + ++ LV E G T E+ G Sbjct: 8 DRAHHPVRDVIVIGSGPAGYTAALYAARAQLAPLVFEGTSFGGALMTTTDVENYPGFRNG 67 Score = 30.2 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 11/32 (34%), Positives = 19/32 (59%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARD 46 D+ +IGGG S + A L+ + +V ++ RD Sbjct: 157 DIAVIGGGDSAMEEATFLTRFARSVTLVHRRD 188 >3T14-A nrPDB Length = 437 Score = 39.0 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 22/135 (16%), Positives = 36/135 (26%), Gaps = 18/135 (13%) Query: 16 VGLIGGGISGLAAAKLLSEY---KINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGP 72 V ++G G G+ AA + E V ++ A D Y WV VG Sbjct: 7 VVILGAGTGGMPAAYEMKEALGSGHEVTLISAND------YFQFVPSNPWVGVGWKERDD 60 Query: 73 TQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMD 132 I + GI + + + DY + Sbjct: 61 IAFPIRHYVERKGIH---------FIAQSAEQIDAEAQNITLADGNTVHYDYLMIATGPK 111 Query: 133 EMGKEIPVDAPWQAR 147 + +P P + Sbjct: 112 LAFENVPGSDPHEGP 126 >1EBD-A nrPDB Length = 455 Score = 39.0 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 36/281 (12%), Positives = 88/281 (31%), Gaps = 41/281 (14%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGR-------------TYTVRNEHVK 61 + ++G G G AA ++ V ++E + +GG + + R E K Sbjct: 5 ETLVVGAGPGGYVAAIRAAQLGQKVTIVE-KGNLGGVCLNVGCIPSKALISASHRYEQAK 63 Query: 62 WVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAY 121 + +G + + ++ +K +V ++L V+G V + Sbjct: 64 HSEE----MGIKAENVTIDFAK--VQEWKASVVKKLTGGVEG--LLKGNKVEIVKGEAYF 115 Query: 122 LDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNIN 181 +D N + + + A ++ + K + T +N Sbjct: 116 VDANTVRVVNGDSAQTYTFKNAIIATGSRPIELPNFKFSNRILDSTG----------ALN 165 Query: 182 VTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQE------RKFVGGSGQVSEQIMGLLG 235 + P + + + + G F E F + ++ + G Sbjct: 166 LGEVPKSLVVIGGGYIGIELGTAYANFGTKVTILEGAGEILSGFEKQMAAIIKKRLKKKG 225 Query: 236 DKVKLSSPVTYIDQTDDNIIVETL---NHEHYECKYVISAI 273 +V ++ ++ +D + V + + YV+ + Sbjct: 226 VEVVTNALAKGAEEREDGVTVTYEANGETKTIDADYVLVTV 266 Score = 30.6 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 10/41 (24%), Positives = 17/41 (41%) Query: 8 NLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRV 48 NL + +IGGG G+ + + V +LE + Sbjct: 165 NLGEVPKSLVVIGGGYIGIELGTAYANFGTKVTILEGAGEI 205 >1PS9-A nrPDB Length = 671 Score = 39.0 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 19/36 (52%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 ++ ++G G +GLA A + V + +A +GG Sbjct: 375 NLAVVGAGPAGLAFAINAAARGHQVTLFDAHSEIGG 410 >5YGQ-A nrPDB Length = 342 Score = 39.0 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 28/153 (18%), Positives = 52/153 (33%), Gaps = 10/153 (6%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDV-GGAYVGPT 73 DV ++G G GL A L + +++ D+VGG+ + E D+ G V Sbjct: 8 DVLIVGAGPCGLFAVFELGLLDVKAHLVDILDKVGGQCAELYPEK-PIYDIPGIPMVTGH 66 Query: 74 QNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDE 133 L++ L + N L + V+ F N + L Sbjct: 67 G-----LTEALMEQIKPFNPTFHLSEMVENVEKIGDPGFRVTTNAGKVFECTVLVVAAGG 121 Query: 134 MGKEIPVDAPWQARHAQEWDKMTMKDLIDKICW 166 G +P P + ++ ++ + K+ Sbjct: 122 -GSFLPKRPPV--PGVEAYEGTSVHYAVRKMED 151 >6GAS-A nrPDB Length = 331 Score = 39.0 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 25/110 (22%), Positives = 44/110 (40%), Gaps = 5/110 (4%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGP 72 ++D+ +IGGG +GL A + +V ++E+ ++GG+ + E + G V Sbjct: 9 VYDITIIGGGPTGLFTAFYGGMRQASVKIIESLPQLGGQLSALYPEKYIYDVAGFPKV-- 66 Query: 73 TQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYL 122 R L L + K + L + V G F V N + Sbjct: 67 ---RAQELVDNLKEQMKKFDPTVCLEEAVDTLEKQADGIFKLVTNKQTHY 113 >4N9X-A nrPDB Length = 411 Score = 38.7 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 14/30 (46%), Positives = 18/30 (60%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLE 43 FDV + GGG+ GLA A L + + VLE Sbjct: 4 FDVVIAGGGMVGLALACGLQGSGLRIAVLE 33 >5XGV-A nrPDB Length = 462 Score = 38.7 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 21/87 (24%), Positives = 35/87 (40%), Gaps = 8/87 (9%) Query: 202 GGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNH 261 G A F+V + ER+ E+ LG +V+ S+ +T + QT D + V T + Sbjct: 86 GDRAFSFAVPHAQVERRL--------EERARSLGVRVRRSTEITSVRQTPDGVQVTTGDG 137 Query: 262 EHYECKYVISAIPPILTAKIHFKPELP 288 E E Y++ + P Sbjct: 138 EVVEGAYLVGCDGSASLVREQAGIPFP 164 Score = 33.3 bits (74), Expect = 0.26, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 16/31 (51%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARD 46 V + GGG GL A L ++ +VLE D Sbjct: 4 VIIAGGGPVGLMLACELGLAGVDTVVLERHD 34 >2GMH-A nrPDB Length = 584 Score = 38.7 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 21/90 (23%), Positives = 35/90 (38%), Gaps = 15/90 (16%) Query: 15 DVGLIGGGISGLAAAKLL------SEYKINVLVLEARDRVGGRT--------YTVRNEHV 60 DV ++G G +GL+AA L E + V ++E +G T Sbjct: 37 DVVIVGAGPAGLSAATRLKQLAAQHEKDLRVCLVEKAAHIGAHTLSGACLDPRAFEELFP 96 Query: 61 KWVDVGGAYVGP-TQNRILRLSKELGIETY 89 W + G P T++R L+++ I Sbjct: 97 DWKEKGAPLNTPVTEDRFGILTEKYRIPVP 126 >5Y77-A nrPDB Length = 473 Score = 38.3 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 28/177 (15%), Positives = 57/177 (32%), Gaps = 8/177 (4%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQ 74 V +IG G++G A+LL+ V + E R + +++ A G Sbjct: 10 QVTIIGAGLAGTLVARLLARNGWQVNLFERRPDP----RIETGARGRSINLALAERGAHA 65 Query: 75 NRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEM 134 R+ L +E+ E + + +V G T P + + + + + + Sbjct: 66 LRLAGLEREVLAEAVMMR---GRMVHVPG-TPPNLQPYGRDDSEVIWSINRDRLNRILLD 121 Query: 135 GKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSA 191 G E + D + + + + + F L S + A Sbjct: 122 GAEAAGASIHFNLGLDSVDFARQRLTLSNVSGERLEKRFHLLIGADGCNSAVRQAMA 178 >2QA2-A nrPDB Length = 499 Score = 38.3 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 17/28 (60%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLE 43 V ++G G +GL A L ++V+VLE Sbjct: 15 VIVVGAGPAGLMLAGELRLGGVDVMVLE 42 >6DLL-A nrPDB Length = 398 Score = 38.3 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 15/48 (31%), Positives = 24/48 (50%), Gaps = 2/48 (4%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEAR--DRVGGRTYTVRNEHV 60 V +IG G SGL +LL + I+ +++E + + V GR E Sbjct: 7 QVAIIGAGPSGLLLGQLLHKAGIDNIIVERQTAEYVLGRIRAGVLEQG 54 >4B1B-A nrPDB Length = 542 Score = 38.3 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 38/286 (13%), Positives = 86/286 (30%), Gaps = 39/286 (13%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLE--------ARDRVGG----------RTYTV 55 +D +IGGG G+A+AK + + VL+ + + +GG + Sbjct: 43 YDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGTCVNVGCVPKKLMHY 102 Query: 56 RNEHVKWVDVGGAYVGPTQNRILRLSKEL--GIETYKVNVNERLVQYVKGKTYPFRGAFP 113 + G + + K+L ++++ ++N + ++ + Sbjct: 103 AGHMGSIFKLDSKAYGWKFDNLKHDWKKLVTTVQSHIRSLNFSYMTGLRSSKVKYINGLA 162 Query: 114 PVWNPLAY-LDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTARE 172 + + + + + + A H + D K+L + ++ Sbjct: 163 KLKDKNTVSYYLKGDLSKEETVTGKYILIATGCRPHIPD-DVEGAKELSITSDDIFSLKK 221 Query: 173 FAYLFVNINVTSEPHEVSALWFLWYVRQCGGT-----ARIFSVTNGGQERKFVGGSGQVS 227 +P + + + +C G + R F Sbjct: 222 ------------DPGKTLVVGASYVALECSGFLNSLGYDVTVAVRSIVLRGFDQQCAVKV 269 Query: 228 EQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAI 273 + M G K + + DD I+VE + V+ AI Sbjct: 270 KLYMEEQGVMFKNGILPKKLTKMDDKILVEFSDKTSELYDTVLYAI 315 >5L46-A nrPDB Length = 841 Score = 37.9 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 12/40 (30%), Positives = 24/40 (60%), Gaps = 1/40 (2%) Query: 15 DVGLIGGGISGLAAAKLLSEYKI-NVLVLEARDRVGGRTY 53 + +IGGG G++ A L++ + +V++LE + G T+ Sbjct: 24 ETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTW 63 >4P9S-A nrPDB Length = 848 Score = 37.9 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 12/40 (30%), Positives = 24/40 (60%), Gaps = 1/40 (2%) Query: 15 DVGLIGGGISGLAAAKLLSEYKI-NVLVLEARDRVGGRTY 53 + +IGGG G++ A L++ + +V++LE + G T+ Sbjct: 25 ETVIIGGGCVGVSLAYHLAKAGMRDVVLLEKSELTAGSTW 64 >5XHU-A nrPDB Length = 329 Score = 37.9 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 23/92 (25%), Positives = 41/92 (44%), Gaps = 7/92 (7%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGG-AYVG 71 ++DV +IGGG GL A ++ V+E ++GG+ ++ D+GG + Sbjct: 2 VYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGGKV-SLFFPEKIIRDIGGIPGIA 60 Query: 72 PTQNRILRLSKELGIETYKVNVNERLVQYVKG 103 Q L ++L + + + L Q V G Sbjct: 61 GKQ-----LIEQLKEQAATFDPDIVLNQRVTG 87 >6J0Z-C nrPDB Length = 491 Score = 37.9 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 11/29 (37%), Positives = 18/29 (62%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLE 43 DV ++G G +GL A L ++V+VL+ Sbjct: 7 DVVVVGAGPTGLMLAGELRLAGVSVVVLD 35 >4K2X-A nrPDB Length = 523 Score = 37.9 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 15/30 (50%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLE 43 +DV + G G +GL A L LVLE Sbjct: 23 YDVVIAGAGPTGLMLACELRLAGARTLVLE 52 >2GV8-A nrPDB Length = 447 Score = 37.9 bits (86), Expect = 0.013, Method: Composition-based stats. Identities = 14/44 (31%), Positives = 20/44 (45%), Gaps = 3/44 (6%) Query: 16 VGLIGGGISGLAAAKLL--SEYKINVLVLEARDRVGGRTYTVRN 57 + +IG G SGL AK L + V + E R GG + + Sbjct: 9 IAIIGAGPSGLVTAKALLAEKAFDQVTLFERRGSPGG-VWNYTS 51 >6GAR-A nrPDB Length = 349 Score = 37.5 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 2/55 (3%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGG 67 +FDV +IGGG +GL +A ++ ++E +GG+ + E + W DVGG Sbjct: 6 LFDVTVIGGGPAGLYSAFYSGLREMRTKIIEFHPHLGGKIHVYP-EKMIW-DVGG 58 >5TR3-A nrPDB Length = 481 Score = 37.1 bits (84), Expect = 0.017, Method: Composition-based stats. Identities = 39/277 (14%), Positives = 74/277 (26%), Gaps = 21/277 (7%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTY---TVRNEHVKWVDVGGAYV 70 FDV +IG G G AA ++ + +E G+ T N Sbjct: 8 FDVVVIGAGPGGYVAAIKAAQLGLKTACIEKYTDAEGKLALGGTCLNVGCIPSKALLDS- 66 Query: 71 GPTQNRILRLSKELGIETYKVNVN-ERLVQYVKGKTYPFRGAFPPVWNPLAYLDY----- 124 GI T +V ++ +V G G ++ Sbjct: 67 SWKYKEAKESFNVHGISTGEVKMDVAAMVGRKAGIVKNLTGGVATLFKANGVTSIQGHGK 126 Query: 125 -----NNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVN 179 D + I + A ++ D +D+ + + V Sbjct: 127 LLAGKKVEVTKADGTTEVIEAENVILASGSRPIDIPPAP--VDQNVIVDSTGALEFQAVP 184 Query: 180 INVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVK 239 + V L + G + + + +++ + G +K Sbjct: 185 KRLGVIGAGVIGLELGSVWARLGAEVTVLEALDTFL-MAADTAVSKEAQKTLTKQGLDIK 243 Query: 240 LSSPVTYIDQTDDNIIVETLNHEH---YECKYVISAI 273 L + VT + + V N E +I A+ Sbjct: 244 LGARVTGSKVNGNEVEVTYTNAEGEQKITFDKLIVAV 280 >1GAL-A nrPDB Length = 583 Score = 37.1 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 17/63 (26%), Positives = 32/63 (50%), Gaps = 9/63 (14%) Query: 8 NLAGHMFDVGLIGGGISGLAAAKLLSEY-KINVLVLEARDRVGGRTYTVRNEHVKWVDVG 66 +++G D + GGG++GL A L+E I+VLV+E+ + ++ ++ Sbjct: 14 DVSGRTVDYIIAGGGLTGLTTAARLTENPNISVLVIESG--------SYESDRGPIIEDL 65 Query: 67 GAY 69 AY Sbjct: 66 NAY 68 >4YNU-A nrPDB Length = 571 Score = 37.1 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 16/32 (50%), Positives = 22/32 (68%), Gaps = 1/32 (3%) Query: 14 FDVGLIGGGISGLAAAKLLSEY-KINVLVLEA 44 +D ++GGG SGL A LSE ++VL+LEA Sbjct: 6 YDYIVVGGGTSGLVVANRLSENPDVSVLLLEA 37 >4X4J-A nrPDB Length = 507 Score = 36.7 bits (83), Expect = 0.022, Method: Composition-based stats. Identities = 12/28 (42%), Positives = 15/28 (53%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLE 43 V + G G +GL A L I V+VLE Sbjct: 25 VVIAGAGPAGLMLAGELRLAGIGVVVLE 52 >5TUM-A nrPDB Length = 410 Score = 36.7 bits (83), Expect = 0.022, Method: Composition-based stats. Identities = 25/171 (14%), Positives = 49/171 (28%), Gaps = 24/171 (14%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLE--ARDRVGGRTYTVRNEHVKWVDVGGAYVGPT 73 + +IG G++G A L + + +++E A R GG+ VR Sbjct: 28 ILVIGAGVAGPAVCYWLRRFGFSPVLIEKYASIRKGGQALDVR---------------GI 72 Query: 74 QNRILRLSKELG-IETYKVNVNERLVQYVKGKTYPFRGA--FPPVWNPLAYLDYNNLWRT 130 I R I + + GK F + + +L Sbjct: 73 ATHIAREMGIYDQICEMRTRIERGRFVDSSGKVLHEEQGEKFGFRQDDEVEILRGDLVEI 132 Query: 131 MDEMGKEIPVDAPWQ----ARHAQEWDKMTMKDLIDKICWTKTAREFAYLF 177 + + ++P ++A + M I++ A Sbjct: 133 LMKTIADVPCYFNQSIISIEQNADNVTVIFMDGRIEQYDLVIAADGIHSAI 183 Score = 32.9 bits (73), Expect = 0.33, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 30/79 (37%), Gaps = 3/79 (3%) Query: 197 YVRQCGGTARIFSVTNGG--QERKFVGGSGQVSEQIMGLLGD-KVKLSSPVTYIDQTDDN 253 +V G G Q+ + G + E +M + D + + I+Q DN Sbjct: 98 FVDSSGKVLHEEQGEKFGFRQDDEVEILRGDLVEILMKTIADVPCYFNQSIISIEQNADN 157 Query: 254 IIVETLNHEHYECKYVISA 272 + V ++ + VI+A Sbjct: 158 VTVIFMDGRIEQYDLVIAA 176 >3ISH-A nrPDB Length = 311 Score = 36.7 bits (83), Expect = 0.023, Method: Composition-based stats. Identities = 16/52 (30%), Positives = 25/52 (48%), Gaps = 1/52 (1%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGR-TYTVRNEHVKWV 63 M D +IGGG +GL+A + + VL + GG+ T + E+ V Sbjct: 1 MIDCAIIGGGPAGLSAGLYATRGGVKNAVLFEKGMPGGQITGSSEIENYPGV 52 >4JDR-A nrPDB Length = 474 Score = 36.7 bits (83), Expect = 0.028, Method: Composition-based stats. Identities = 9/36 (25%), Positives = 21/36 (58%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 V ++G G +G +AA ++ + +++E + +GG Sbjct: 8 QVVVLGAGPAGYSAAFRCADLGLETVIVERYNTLGG 43 >5J7X-A nrPDB Length = 549 Score = 36.3 bits (82), Expect = 0.029, Method: Composition-based stats. Identities = 16/53 (30%), Positives = 22/53 (41%), Gaps = 4/53 (7%) Query: 14 FDVGLIGGGISGLAAAKLLSEY-KINVLVLEARDRVGGRTYTVRNEHVKWVDV 65 D +IG G SG+ L + K+ V + EA +GG T N V Sbjct: 13 LDALIIGSGFSGIYLLHKLRDELKLKVKIFEAESDIGG---TWNNNRYPGARV 62 >6AON-A nrPDB Length = 478 Score = 36.3 bits (82), Expect = 0.030, Method: Composition-based stats. Identities = 40/279 (14%), Positives = 79/279 (28%), Gaps = 32/279 (11%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPT 73 FDV +IG G G AA ++ ++V ++A +N G Sbjct: 8 FDVVVIGAGPGGYIAAIRAAQLGMSVACIDA----------WQNGQGGPAPGGTCTNVGC 57 Query: 74 QNRILRL------------SKELGIETYKVNVNERLVQYVKGKTYPFRGA---FPPVWNP 118 L E GIE V++ + K + N Sbjct: 58 IPSKALLQSSEHYEQANHHFAEHGIEVKGVSLKLDTLIGRKNTVVKQNNDGILYLFKKNK 117 Query: 119 LAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKI-CWTKTAREFAYLF 177 + Y + + G I V A + + ++ + Sbjct: 118 VTYFHGKGAFAGQVDGGWSIKVTGTTDADLVAKHVIVATGSSARELPGLPFDEKNILSND 177 Query: 178 VNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQER--KFVGGSGQVS----EQIM 231 +N+ + P ++ + + G R E +F+ + Q + Sbjct: 178 GALNIGAVPKKLGVIGAGVIGLEMGSVWRRLGAEVTILEAMPEFLAAADQQVAKEALKSF 237 Query: 232 GLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVI 270 G ++ + I +I V ++ + E K V+ Sbjct: 238 AKQGLDIQTGVKIGEIKAAAKSITVPYVDAKGAEQKLVV 276 Score = 30.6 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 20/44 (45%) Query: 1 MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEA 44 +++ N+ +G+IG G+ GL + V +LEA Sbjct: 174 LSNDGALNIGAVPKKLGVIGAGVIGLEMGSVWRRLGAEVTILEA 217 >3O0H-A nrPDB Length = 484 Score = 36.3 bits (82), Expect = 0.031, Method: Composition-based stats. Identities = 44/273 (16%), Positives = 77/273 (28%), Gaps = 28/273 (10%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGR------------TYTVRNEHVK 61 FD+ +IG G G+ AA+L V + E R+GG Y + Sbjct: 27 FDLFVIGSGSGGVRAARLAGALGKRVAIAE-EYRIGGTCVIRGCVPKKLYFYASQYAQEF 85 Query: 62 WVDVGGAYVGPTQ-NRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA 120 +G G + I K + + +++ E L + + V+ Sbjct: 86 SKSIG---FGWKYADPIFNWEKLVAAKNKEISRLEGLYREGLQNSNVHIYESRAVFVDEH 142 Query: 121 YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNI 180 L+ + G+ I + A A K+ I T+ E L Sbjct: 143 TLELSV-------TGERISAEKILIATGA----KIVSNSAIKGSDLCLTSNEIFDLEKLP 191 Query: 181 NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL 240 + G R F Q+ M G + Sbjct: 192 KSIVIVGGGYIGVEFANIFHGLGVKTTLLHRGDLILRNFDYDLRQLLNDAMVAKGISIIY 251 Query: 241 SSPVTYIDQTDDNIIVETLNHEHYECKYVISAI 273 + V+ + T++ V N + V+ A Sbjct: 252 EATVSQVQSTENCYNVVLTNGQTICADRVMLAT 284 Score = 31.7 bits (70), Expect = 0.71, Method: Composition-based stats. Identities = 10/48 (20%), Positives = 20/48 (41%) Query: 1 MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRV 48 +T E +L + ++GGG G+ A + + +L D + Sbjct: 179 LTSNEIFDLEKLPKSIVIVGGGYIGVEFANIFHGLGVKTTLLHRGDLI 226 >1FOH-A nrPDB Length = 664 Score = 36.3 bits (82), Expect = 0.032, Method: Composition-based stats. Identities = 12/24 (50%), Positives = 17/24 (70%) Query: 15 DVGLIGGGISGLAAAKLLSEYKIN 38 DV ++G G +GL AA++LSEY Sbjct: 9 DVLIVGAGPAGLMAARVLSEYVRQ 32 >4MOP-A nrPDB Length = 633 Score = 36.3 bits (82), Expect = 0.032, Method: Composition-based stats. Identities = 8/30 (26%), Positives = 14/30 (46%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLE 43 +DV ++G G G A+ L V + + Sbjct: 47 YDVVIVGSGPIGCTYARELVGAGYKVAMFD 76 >6C6P-A nrPDB Length = 458 Score = 36.0 bits (81), Expect = 0.039, Method: Composition-based stats. Identities = 13/32 (40%), Positives = 19/32 (59%), Gaps = 1/32 (3%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARD 46 +V ++G G+ G A A +LS V V+E RD Sbjct: 9 EVIIVGAGVLGSALAAVLSRDGRKVTVIE-RD 39 >2EQ6-A nrPDB Length = 464 Score = 36.0 bits (81), Expect = 0.041, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 22/37 (59%), Gaps = 1/37 (2%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 +D+ +IG G G AA ++ + VL +EA + VGG Sbjct: 7 YDLIVIGTGPGGYHAAIRAAQLGLKVLAVEAGE-VGG 42 >3NIX-A nrPDB Length = 421 Score = 36.0 bits (81), Expect = 0.042, Method: Composition-based stats. Identities = 11/29 (37%), Positives = 18/29 (62%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLE 43 DV +IG G +G AA L+++ V ++E Sbjct: 7 DVLVIGAGPAGTVAASLVNKSGFKVKIVE 35 >4EMJ-A nrPDB Length = 410 Score = 36.0 bits (81), Expect = 0.043, Method: Composition-based stats. Identities = 17/64 (26%), Positives = 28/64 (43%), Gaps = 9/64 (14%) Query: 17 GLIGGGISGLAAAKLLSEYKINVLVLEARD---------RVGGRTYTVRNEHVKWVDVGG 67 ++GGG+ G A + ++V +LEA D R+G + E V++G Sbjct: 147 LIVGGGLIGCEVATTARKLGLSVTILEAGDELLVRVLGRRIGAWLRGLLTELGVQVELGT 206 Query: 68 AYVG 71 VG Sbjct: 207 GVVG 210 >2E5V-A nrPDB Length = 472 Score = 36.0 bits (81), Expect = 0.043, Method: Composition-based stats. Identities = 10/28 (35%), Positives = 15/28 (53%) Query: 18 LIGGGISGLAAAKLLSEYKINVLVLEAR 45 +IG GI+GL+A L V ++ R Sbjct: 4 IIGSGIAGLSAGVALRRAGKKVTLISKR 31 >2R9Z-A nrPDB Length = 463 Score = 36.0 bits (81), Expect = 0.046, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 23/37 (62%), Gaps = 1/37 (2%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 FD+ IGGG GLA A+ + + V ++E++ +GG Sbjct: 5 FDLIAIGGGSGGLAVAEKAAAFGKRVALIESK-ALGG 40 Score = 34.8 bits (78), Expect = 0.093, Method: Composition-based stats. Identities = 12/37 (32%), Positives = 17/37 (45%) Query: 12 HMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRV 48 V +IG G G+ A LL + V V+ DR+ Sbjct: 165 QPKRVAIIGAGYIGIELAGLLRSFGSEVTVVALEDRL 201 >4H7U-A nrPDB Length = 602 Score = 35.6 bits (80), Expect = 0.053, Method: Composition-based stats. Identities = 16/36 (44%), Positives = 21/36 (58%), Gaps = 1/36 (2%) Query: 10 AGHMFDVGLIGGGISGLAAAKLLSEYKI-NVLVLEA 44 +G +D + GGG +GL A LSE VLV+EA Sbjct: 37 SGVDYDFIVAGGGTAGLVVASRLSENSNWKVLVIEA 72 >3SM8-A nrPDB Length = 381 Score = 35.6 bits (80), Expect = 0.062, Method: Composition-based stats. Identities = 15/45 (33%), Positives = 22/45 (48%), Gaps = 5/45 (11%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVG----GRTYTV 55 D +IG GI+G + LS + V+VLE + G GR+ Sbjct: 11 DYLVIGAGIAGASTGYWLSAHGR-VVVLEREAQPGYHSTGRSAAH 54 >4TXK-A nrPDB Length = 615 Score = 35.2 bits (79), Expect = 0.064, Method: Composition-based stats. Identities = 10/29 (34%), Positives = 16/29 (55%) Query: 17 GLIGGGISGLAAAKLLSEYKINVLVLEAR 45 ++G G GL AA L+ V+++E R Sbjct: 88 LVVGAGPCGLRAAVELALLGARVVLVEKR 116 >2BRY-A nrPDB Length = 497 Score = 35.2 bits (79), Expect = 0.064, Method: Composition-based stats. Identities = 10/29 (34%), Positives = 16/29 (55%) Query: 17 GLIGGGISGLAAAKLLSEYKINVLVLEAR 45 ++G G GL AA L+ V+++E R Sbjct: 96 LVVGAGPCGLRAAVELALLGARVVLVEKR 124 >4YKF-A nrPDB Length = 521 Score = 35.2 bits (79), Expect = 0.076, Method: Composition-based stats. Identities = 16/40 (40%), Positives = 23/40 (57%), Gaps = 3/40 (7%) Query: 7 PNLAGHMFD---VGLIGGGISGLAAAKLLSEYKINVLVLE 43 P+ G +F V +IGGG SG+ AA L+ +V +LE Sbjct: 346 PHCDGPLFKGKRVAVIGGGNSGVEAAIDLAGIVEHVTLLE 385 >3QJ4-A nrPDB Length = 342 Score = 35.2 bits (79), Expect = 0.076, Method: Composition-based stats. Identities = 20/68 (29%), Positives = 29/68 (42%), Gaps = 5/68 (7%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRV---GGRTYTVRNEHVKW--VDVGG 67 M V ++G G++G A LL L L D+ GGR T + H D+G Sbjct: 1 MAQVLIVGAGMTGSLCAALLRRQTSGPLYLAVWDKADDSGGRMTTACSPHNPQCTADLGA 60 Query: 68 AYVGPTQN 75 Y+ T + Sbjct: 61 QYITCTPH 68 >1FL2-A nrPDB Length = 310 Score = 35.2 bits (79), Expect = 0.076, Method: Composition-based stats. Identities = 16/40 (40%), Positives = 23/40 (57%), Gaps = 3/40 (7%) Query: 7 PNLAGHMFD---VGLIGGGISGLAAAKLLSEYKINVLVLE 43 P+ G +F V +IGGG SG+ AA L+ +V +LE Sbjct: 135 PHCDGPLFKGKRVAVIGGGNSGVEAAIDLAGIVEHVTLLE 174 >3COX-A nrPDB Length = 507 Score = 34.8 bits (78), Expect = 0.092, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 20/54 (37%), Gaps = 5/54 (9%) Query: 10 AGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWV 63 G +IG G G AA L++ I ++E GR++ K Sbjct: 8 DGDRVPALVIGSGYGGAVAALRLTQAGIPTQIVEM-----GRSWDTPGSDGKIF 56 >3LAD-A nrPDB Length = 476 Score = 34.8 bits (78), Expect = 0.097, Method: Composition-based stats. Identities = 10/30 (33%), Positives = 16/30 (53%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLE 43 FDV +IG G G AA ++ + ++E Sbjct: 4 FDVIVIGAGPGGYVAAIKSAQLGLKTALIE 33 Score = 31.7 bits (70), Expect = 0.71, Method: Composition-based stats. Identities = 11/30 (36%), Positives = 16/30 (53%) Query: 18 LIGGGISGLAAAKLLSEYKINVLVLEARDR 47 +IG G+ GL + + V VLEA D+ Sbjct: 185 VIGAGVIGLELGSVWARLGAEVTVLEAMDK 214 >4USR-A nrPDB Length = 361 Score = 34.8 bits (78), Expect = 0.100, Method: Composition-based stats. Identities = 13/38 (34%), Positives = 21/38 (55%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 + DV +IGGG + L A L ++ L+L+ + GG Sbjct: 7 ILDVIVIGGGQAALTTAYFLRRTSLSYLLLDEQPGPGG 44 >4RG3-A nrPDB Length = 548 Score = 34.8 bits (78), Expect = 0.10, Method: Composition-based stats. Identities = 29/130 (22%), Positives = 44/130 (33%), Gaps = 9/130 (6%) Query: 12 HMFDVGLIGGGISGLAAAKLL-SEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGA-Y 69 H D +IG G G+ A L E + + + D GG T+ D Y Sbjct: 15 HTVDAVVIGAGFGGIYAVHKLHHELGLTTVGFDKADGPGG-TWYWNRYPGALSDTESHLY 73 Query: 70 VGPTQNRILRLS--KELGIETYK-VNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNN 126 +L+ S K I + + E +V + + G YLD N Sbjct: 74 RFSFDRDLLQESTWKTTYITQPEILEYLEDVVDRFDLRRHFKFGTE---VTSALYLDDEN 130 Query: 127 LWRTMDEMGK 136 LW + G+ Sbjct: 131 LWEVTTDHGE 140 Score = 34.0 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 20/58 (34%), Positives = 27/58 (46%), Gaps = 5/58 (8%) Query: 233 LLGDKVKLSSPVTYIDQTDDNI--IVETLNHEHYECKYVISAIPPILTAKIHFKPELP 288 L K + VT DD V T + E Y KYV++A+ L + I+F P LP Sbjct: 109 DLRRHFKFGTEVTSALYLDDENLWEVTTDHGEVYRAKYVVNAV--GLLSAINF-PNLP 163 >5TUK-A nrPDB Length = 408 Score = 34.4 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 26/71 (36%), Gaps = 2/71 (2%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLE--ARDRVGGRTYTVRNEHVKWVDVGGAYVGPT 73 + +IG GI+G A L + + +++E A R GG +R + G Y Sbjct: 28 ILVIGAGIAGPAVCYWLRRFGFSPILVERCANLRKGGHAVDIRGVAIDLAKSMGIYKKIC 87 Query: 74 QNRILRLSKEL 84 R Sbjct: 88 NMRTQVELGRY 98 Score = 31.3 bits (69), Expect = 1.00, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 26/63 (41%), Gaps = 2/63 (3%) Query: 224 GQVSEQIMGLLGD-KVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPP-ILTAKI 281 G + + ++ +GD + V I Q D+++ V+ + VI A T ++ Sbjct: 127 GDLVQILIDAMGDVPCHFNQWVESIKQRDNDVEVQFKDGRTELYDLVIGADGLHSTTRRM 186 Query: 282 HFK 284 F Sbjct: 187 VFD 189 >3GMC-A nrPDB Length = 415 Score = 34.4 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 18/71 (25%), Positives = 30/71 (42%), Gaps = 6/71 (8%) Query: 1 MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRV---GGRTYTVRN 57 M ++ K G + GGG +GL AA L + +V + E + G Y N Sbjct: 37 MANVNKT--PGKTRRAEVAGGGFAGLTAAIALKQNGWDVRLHEKSSELRAFGAGIYLWHN 94 Query: 58 EHVKWVDVGGA 68 ++ ++ GA Sbjct: 95 -GLRVLEGLGA 104 >6ER9-A nrPDB Length = 549 Score = 34.4 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 12/43 (27%), Positives = 18/43 (41%), Gaps = 2/43 (4%) Query: 15 DVGLIGGGISGLAAAKLLSE-YKINVLVLEARDRVGGRTYTVR 56 D +IG G G+ A L + V+ + D GG T+ Sbjct: 11 DAVVIGAGFGGIYAVHKLHNEQGLTVVGFDKADGPGG-TWYWN 52 Score = 31.3 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 5/58 (8%) Query: 233 LLGDKVKLSSPVTYIDQ-TDDNI-IVETLNHEHYECKYVISAIPPILTAKIHFKPELP 288 L + + VT D+N+ V T E Y KYV++A+ L + I+F P+LP Sbjct: 102 DLRRHFRFGTEVTSAIYLEDENLWEVSTDKGEVYRAKYVVNAV--GLLSAINF-PDLP 156 >6BZ0-A nrPDB Length = 480 Score = 34.4 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 14/43 (32%), Positives = 19/43 (44%) Query: 7 PNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVG 49 N FD+ +IGGG G AA ++ V +E R G Sbjct: 1 SNAMSQQFDLVVIGGGPGGYEAAIRAAQLGFKVACIEKRIHNG 43 Score = 29.4 bits (64), Expect = 4.0, Method: Composition-based stats. Identities = 10/29 (34%), Positives = 14/29 (48%) Query: 18 LIGGGISGLAAAKLLSEYKINVLVLEARD 46 +IG G+ GL + V+V EA D Sbjct: 188 VIGAGVIGLELGSVWRRLGAEVVVFEAMD 216 >6A37-A nrPDB Length = 552 Score = 34.0 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 44/127 (34%), Gaps = 6/127 (4%) Query: 14 FDVGLIGGGISGLAAAKLLS-EYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGP 72 FD +IG G GL + K L ++ + V + VGG T+ D Sbjct: 27 FDAIIIGAGFGGLYSLKKLRDDFNLKVRAFDRATEVGG-TWFWNQYPGALSD--SETHLY 83 Query: 73 TQNRILRLSKELGIETYKVNVNE--RLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRT 130 + L +E+ I+ ++ + ++ V K + AY D N + Sbjct: 84 CYSWDKELLQEMEIKRKYISQPDVLAYLKRVADKHDLRKDIQFETGIRSAYFDEENSFWN 143 Query: 131 MDEMGKE 137 + E Sbjct: 144 VTTENDE 150 >4HA6-A nrPDB Length = 508 Score = 34.0 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 18/78 (23%), Positives = 31/78 (39%), Gaps = 15/78 (19%) Query: 15 DVGLIGGGISG-LAAAKLLSEYKINVLVLEARDR--------------VGGRTYTVRNEH 59 D+ ++GGG +G L AA+L + VL++EA + + GR+Y Sbjct: 3 DIVIVGGGSAGSLLAARLSEDPDSRVLLIEAGEEPTDPDIWNPAAWPALQGRSYDWDYRT 62 Query: 60 VKWVDVGGAYVGPTQNRI 77 G + R+ Sbjct: 63 EAQAGTAGRAHHWARGRL 80 >5EB4-A nrPDB Length = 532 Score = 34.0 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 50/310 (16%), Positives = 91/310 (29%), Gaps = 52/310 (16%) Query: 3 DLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTV--RNEHV 60 + + G +D +IGGG SG A LSE K VL+LE G T Sbjct: 17 NATDTSSEGS-YDYIVIGGGTSGCPLAATLSE-KYKVLLLER-----GTIATEYPNTLTA 69 Query: 61 KWVDVGGAYVGPTQNRILRLSKELGIETYKVN-------VNERLVQYVKGKTYPFRG--- 110 + + R E GI+ + +N + Y G Sbjct: 70 DGFAYNLQQQDDGKTPVERFVSEDGIDNVRARILGGTTIINAGVYARANISFYSQTGIEW 129 Query: 111 -------AFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQE----------WD 153 + V + + N W+++ G P +D Sbjct: 130 DLDLVNKTYEWVEDAIVVKPNNQSWQSVIGEGFLEAGILPDNGFSLDHEAGTRLTGSTFD 189 Query: 154 KMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNG 213 + D++ + + V + F I++ ++G Sbjct: 190 NNGTRHAADELLNKGDPNNL--------LVAVQASVEKILFSSNTSNLSAIGVIYTDSDG 241 Query: 214 GQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYV---- 269 + FV G+G+V + ++ L S V + + + Y ++V Sbjct: 242 NSHQAFVRGNGEVIVSAGTIGTPQLLLLSGVGPESYLSS-LNITVVQPNPYVGQFVYDNP 300 Query: 270 ---ISAIPPI 276 I+ +PP Sbjct: 301 RNFINILPPN 310 >3IWA-A nrPDB Length = 472 Score = 34.0 bits (76), Expect = 0.16, Method: Composition-based stats. Identities = 15/55 (27%), Positives = 28/55 (50%), Gaps = 7/55 (12%) Query: 1 MTDLEKPNL------AGHMFDVGLIGGGISGLAAAKLLSEY-KINVLVLEARDRV 48 +T+L++ AG + ++GGG GL A L++ I+ V+E D++ Sbjct: 141 VTNLDEAEFVQHAISAGEVSKAVIVGGGFIGLEMAVSLADMWGIDTTVVELADQI 195 >2CUL-A nrPDB Length = 232 Score = 34.0 bits (76), Expect = 0.16, Method: Composition-based stats. Identities = 9/29 (31%), Positives = 16/29 (55%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVL 42 + V ++G G SG A L++ + V +L Sbjct: 4 YQVLIVGAGFSGAETAFWLAQKGVRVGLL 32 >3FG2-P nrPDB Length = 404 Score = 34.0 bits (76), Expect = 0.16, Method: Composition-based stats. Identities = 14/45 (31%), Positives = 17/45 (37%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV 60 V +IG G GL A + V V+E RV R T Sbjct: 145 VVVIGAGFIGLEFAATARAKGLEVDVVELAPRVMARVVTPEISSY 189 >5OC1-A nrPDB Length = 565 Score = 34.0 bits (76), Expect = 0.16, Method: Composition-based stats. Identities = 14/32 (43%), Positives = 22/32 (68%), Gaps = 1/32 (3%) Query: 14 FDVGLIGGGISG-LAAAKLLSEYKINVLVLEA 44 FD ++G G +G + AA+L + ++VLVLEA Sbjct: 2 FDYVVVGAGNAGNVVAARLTEDPDVSVLVLEA 33 >3L8K-A nrPDB Length = 466 Score = 34.0 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 11/43 (25%), Positives = 18/43 (41%) Query: 6 KPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRV 48 K + D+ +IG G GL A + + ++E DR Sbjct: 165 KTSFRKLPQDMVIIGAGYIGLEIASIFRLMGVQTHIIEMLDRA 207 >1DXL-A nrPDB Length = 470 Score = 33.6 bits (75), Expect = 0.18, Method: Composition-based stats. Identities = 43/289 (14%), Positives = 84/289 (29%), Gaps = 53/289 (18%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRT---------------------- 52 DV +IGGG G AA ++ +E R +GG Sbjct: 8 DVVIIGGGPGGYVAAIKAAQLGFKTTCIEKRGALGGTCLNVGCIPSKALLHSSHMYHEAK 67 Query: 53 YTVRNEHVKWVDV---GGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFR 109 ++ N VK +V A +G + L++ GIE V+ P Sbjct: 68 HSFANHGVKVSNVEIDLAAMMGQKDKAVSNLTR--GIEGLFKKNKVTYVKGYGKFVSPSE 125 Query: 110 GAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKT 169 + + + ++ K +P + + + + ++ K+ Sbjct: 126 ISVDTIEGENTVVKGKHIIIATGSDVKSLPGVTIDEKKIVSSTGALALSEIPKKLVVIGA 185 Query: 170 -AREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSE 228 V + SE V + I + ++F + Sbjct: 186 GYIGLEMGSVWGRIGSEVTVVEF------------ASEIVPTMDAEIRKQF--------Q 225 Query: 229 QIMGLLGDKVKLSSPVTYIDQTDDNIIVETL-----NHEHYECKYVISA 272 + + G K KL + V +D + D + + E V+ + Sbjct: 226 RSLEKQGMKFKLKTKVVGVDTSGDGVKLTVEPSAGGEQTIIEADVVLVS 274 >2EEZ-A nrPDB Length = 369 Score = 33.6 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 24/147 (16%), Positives = 41/147 (27%), Gaps = 20/147 (13%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEAR--------DRVGGRTYTVRNEHVKWVD 64 V ++GGG G AAK+ V +L+ D GGR T+ Sbjct: 166 PASVVILGGGTVGTNAAKIALGMGAQVTILDVNHKRLQYLDDVFGGRVITLTATEANIKK 225 Query: 65 --------VGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVW 116 +G V + L L + + +V + P Sbjct: 226 SVQHADLLIGAVLVPGAKAPKLVTRDMLSL----MKEGAVIVDVAVDQGGCVETIRPTTH 281 Query: 117 NPLAYLDYNNLWRTMDEMGKEIPVDAP 143 Y+ + + M +P + Sbjct: 282 AEPTYVVDGVVHYGVANMPGAVPRTST 308 >3NTA-A nrPDB Length = 574 Score = 33.6 bits (75), Expect = 0.20, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 16/33 (48%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRV 48 ++GGG GL + L I +LE D+V Sbjct: 154 ATVVGGGFIGLEMMESLHHLGIKTTLLELADQV 186 >1ZDL-A nrPDB Length = 517 Score = 33.6 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 13/28 (46%), Positives = 17/28 (60%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLV 41 FD+ +IGGG GLA AK ++ V V Sbjct: 33 FDLLVIGGGSGGLACAKEAAQLGKKVAV 60 >1KNR-A nrPDB Length = 540 Score = 33.6 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 13/31 (41%), Positives = 19/31 (61%), Gaps = 1/31 (3%) Query: 12 HMFDVGLIGGGISGLAAAKLLSEYKINVLVL 42 H DV +IG G +GL+ A L++ V+VL Sbjct: 7 HSCDVLIIGSGAAGLSLALRLADQ-HQVIVL 36 >5U8W-A nrPDB Length = 481 Score = 33.3 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 10/30 (33%), Positives = 15/30 (50%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLE 43 FDV +IG G G AA ++ + +E Sbjct: 8 FDVVVIGAGPGGYVAAIRAAQLGLKTACIE 37 Score = 31.7 bits (70), Expect = 0.85, Method: Composition-based stats. Identities = 11/30 (36%), Positives = 16/30 (53%) Query: 18 LIGGGISGLAAAKLLSEYKINVLVLEARDR 47 +IG G+ GL + + V VLEA D+ Sbjct: 189 VIGAGVIGLELGSVWARLGAEVTVLEALDK 218 >4NTC-A nrPDB Length = 335 Score = 33.3 bits (74), Expect = 0.25, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 18/32 (56%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEA 44 + DV +IG G +GL+ A L+ +V ++ Sbjct: 14 LVDVLIIGAGPAGLSTATGLARQLHTAVVFDS 45 >6CMZ-A nrPDB Length = 466 Score = 33.3 bits (74), Expect = 0.25, Method: Composition-based stats. Identities = 19/75 (25%), Positives = 33/75 (44%), Gaps = 6/75 (8%) Query: 17 GLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNR 76 ++G G GL + + ++V V+EA +RV E V+ V A +G R Sbjct: 182 VVVGAGYIGLELGIVYRKLGVDVSVVEAAERV---LPAYDAELVRPVADSLARLG---VR 235 Query: 77 ILRLSKELGIETYKV 91 + K LG++ + Sbjct: 236 LWLGHKVLGLDKHGA 250 >1Y56-A nrPDB Length = 493 Score = 33.3 bits (74), Expect = 0.27, Method: Composition-based stats. Identities = 22/89 (24%), Positives = 35/89 (39%), Gaps = 12/89 (13%) Query: 411 FPPGIMTQYGRVIRQPVGRIYFAGTETAT--QWSGYMEGAVEAGERAAREVLNALGKVAK 468 F G + + IY AG+ + ++ Y+EG + +L G A+ Sbjct: 327 FRRGYYSPVLDEYHRIKDGIYVAGSAVSIKPHYANYLEGKL-----VGAYILKEFGYDAQ 381 Query: 469 KDIWVE-----EPESKDVPAIEITHTFLE 492 I+ E EPES +P I + LE Sbjct: 382 PCIYEEKLREYEPESLSIPRIPLDKFNLE 410 >1LVL-A nrPDB Length = 458 Score = 33.3 bits (74), Expect = 0.27, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 18/36 (50%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRV 48 + ++GGG GL + V V+EAR+R+ Sbjct: 171 PQHLVVVGGGYIGLELGIAYRKLGAQVSVVEARERI 206 >5J72-A nrPDB Length = 638 Score = 33.3 bits (74), Expect = 0.27, Method: Composition-based stats. Identities = 27/146 (18%), Positives = 51/146 (34%), Gaps = 31/146 (21%) Query: 26 LAAAKLLSEYKINVLVLEARDR---VGGRT---------------YTVRNEHVKWVDV-- 65 LA + L INV++ D+ +G RT Y N V++ Sbjct: 486 LATTEYLRSKGINVVMTRDTDKTMALGERTALSNTIKPDLFTSIHYNASNGSGNGVEIYY 545 Query: 66 ------GGAYVGPTQNRILRLSKEL-----GIETYKVNVNERLVQYVKGKTYPFRGAFPP 114 GG N + R+ ++ GI+T ++ + + ++ YP Sbjct: 546 KVKDKNGGTTKTAASNILKRILEKFNMKNRGIKTRTLDNGKDYLYVLRNNNYPAILVECA 605 Query: 115 VWNPLAYLDYNNLWRTMDEMGKEIPV 140 + + +D N + MG +I + Sbjct: 606 FIDNKSDMDKLNTAEKVKTMGTQIGI 631 >2BS2-A nrPDB Length = 660 Score = 33.3 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 15/71 (21%), Positives = 30/71 (42%), Gaps = 2/71 (2%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQ 74 D +IGGG++GL AA + ++ +VL R+++ + +G + + Sbjct: 7 DSLVIGGGLAGLRAAVATQQKGLSTIVLSLIPVK--RSHSAAAQGGMQASLGNSKMSDGD 64 Query: 75 NRILRLSKELG 85 N L + Sbjct: 65 NEDLHFMDTVK 75 >2X3N-A nrPDB Length = 399 Score = 32.9 bits (73), Expect = 0.33, Method: Composition-based stats. Identities = 34/162 (20%), Positives = 58/162 (35%), Gaps = 21/162 (12%) Query: 10 AGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEA--RDRVGGRTYTVRNEHVKWVDVGG 67 H+ DV + G GI G A LL V+V+E R+R ++ ++ V+ G Sbjct: 4 DNHI-DVLINGCGIGGAMLAYLLGRQGHRVVVVEQARRERAINGADLLKPAGIRVVEAAG 62 Query: 68 --AYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYN 125 A V R+ + + L++Y + RG F + P L Sbjct: 63 LLAEVTRRGGRVRHELEVY--------HDGELLRYFNYSSVDARGYF--ILMPCESLRRL 112 Query: 126 NLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWT 167 L + E E+ + +A E + ID++ Sbjct: 113 VLEKIDGEATVEMLFETRIEAVQRDE------RHAIDQVRLN 148 >5EZ7-A nrPDB Length = 392 Score = 32.9 bits (73), Expect = 0.33, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 19/36 (52%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 D+ ++GGGI+GL L +++E+ GG Sbjct: 9 DILIVGGGIAGLWLNARLRRAGYATVLVESASLGGG 44 >5ZYN-B nrPDB Length = 471 Score = 32.9 bits (73), Expect = 0.36, Method: Composition-based stats. Identities = 14/36 (38%), Positives = 26/36 (72%), Gaps = 1/36 (2%) Query: 16 VGLIGGGISGLAAA-KLLSEYKINVLVLEARDRVGG 50 V +IG G++GL + +L+S+Y+I V++L+ +GG Sbjct: 7 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 42 >5KXJ-A nrPDB Length = 557 Score = 32.9 bits (73), Expect = 0.37, Method: Composition-based stats. Identities = 14/28 (50%), Positives = 19/28 (67%), Gaps = 1/28 (3%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVL 42 DV +IG G +GL+ A L+E K V+VL Sbjct: 10 DVLIIGSGAAGLSLALRLAE-KHKVIVL 36 >3II4-A nrPDB Length = 466 Score = 32.9 bits (73), Expect = 0.38, Method: Composition-based stats. Identities = 8/30 (26%), Positives = 17/30 (56%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLE 43 +DV ++G G G AA ++ ++ ++E Sbjct: 6 YDVVVLGAGPGGYVAAIRAAQLGLSTAIVE 35 >3RED-A nrPDB Length = 521 Score = 32.5 bits (72), Expect = 0.42, Method: Composition-based stats. Identities = 19/41 (46%), Positives = 22/41 (53%), Gaps = 2/41 (4%) Query: 3 DLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLE 43 D L G +D ++GGG SG A LSE K VLVLE Sbjct: 17 DATDLELEGS-YDYVIVGGGTSGCPLAATLSE-KYKVLVLE 55 >3GDN-A nrPDB Length = 521 Score = 32.5 bits (72), Expect = 0.42, Method: Composition-based stats. Identities = 19/41 (46%), Positives = 22/41 (53%), Gaps = 2/41 (4%) Query: 3 DLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLE 43 D L G +D ++GGG SG A LSE K VLVLE Sbjct: 17 DATDLELEGS-YDYVIVGGGTSGCPLAATLSE-KYKVLVLE 55 >4JNQ-A nrPDB Length = 345 Score = 32.5 bits (72), Expect = 0.43, Method: Composition-based stats. Identities = 14/63 (22%), Positives = 24/63 (38%), Gaps = 2/63 (3%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVD--VGGAYVGPT 73 V +IG G +G AA + + +V+ + G T E+ V G ++ Sbjct: 29 VIVIGSGPAGYTAAIYAARAMLKPVVIAGLQQGGQLMITTDVENYPGYAEPVQGPWMMEQ 88 Query: 74 QNR 76 R Sbjct: 89 MAR 91 >4CBQ-A nrPDB Length = 314 Score = 32.5 bits (72), Expect = 0.45, Method: Composition-based stats. Identities = 15/60 (25%), Positives = 24/60 (40%), Gaps = 5/60 (8%) Query: 12 HMFDVGLIGGGISGLAAAKLLSEYKINVLVLE---ARDR-VGGRTYTVR-NEHVKWVDVG 66 ++ DV +IG G + AA L + ++ E A GG+ T E+ G Sbjct: 3 NIHDVVIIGSGPAAHTAAIYLGRSSLKPVMYEGFMAGGVAAGGQLTTTTIIENFPGFPNG 62 >3Q9T-A nrPDB Length = 577 Score = 32.5 bits (72), Expect = 0.46, Method: Composition-based stats. Identities = 14/36 (38%), Positives = 21/36 (58%), Gaps = 1/36 (2%) Query: 10 AGHMFDVGLIGGGISGLAAAKLLSEY-KINVLVLEA 44 G FD ++GGG +G A L+E + VL++EA Sbjct: 3 DGSHFDFVIVGGGTAGNTVAGRLAENPNVTVLIVEA 38 >4P2C-A nrPDB Length = 297 Score = 32.5 bits (72), Expect = 0.51, Method: Composition-based stats. Identities = 30/136 (22%), Positives = 45/136 (33%), Gaps = 30/136 (22%) Query: 366 KDIRKRKICELYAKVLGSQEALY---PVHYEEK-NWCEEQYSGGCYTAYFPPGIMTQYGR 421 + +R R+I + + L +Y P + NW G + P +Y Sbjct: 167 QALRFRQIQREFRQALSETAPVYTMTPEDVDLTLNW-------GRISNVLP-----EYRG 214 Query: 422 VIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESK-- 479 VGRI F + G R+ R V +PE + Sbjct: 215 EAGVRVGRISFNNISAILGTVAVILNCHHQGARSVRAVNEE-----------SQPECQIT 263 Query: 480 -DVPAIEITHTFLERN 494 D P I+IT+T E N Sbjct: 264 GDRPVIKITNTLWESN 279 >1C0L-A nrPDB Length = 363 Score = 32.1 bits (71), Expect = 0.53, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 21/31 (67%), Gaps = 1/31 (3%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARD 46 V ++G G+ GL++A +L+ +V +L ARD Sbjct: 9 VVVLGSGVIGLSSALILARKGYSVHIL-ARD 38 >6BPY-A nrPDB Length = 374 Score = 32.1 bits (71), Expect = 0.55, Method: Composition-based stats. Identities = 12/46 (26%), Positives = 20/46 (43%), Gaps = 4/46 (8%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEA----RDRVGGRTYTVRN 57 V +IG G + AA LS ++ ++ E GG+ T + Sbjct: 7 VVIIGSGPAAHTAAIYLSRAELKPVLYEGMLANGTAAGGQLTTTTD 52 Score = 29.8 bits (65), Expect = 2.7, Method: Composition-based stats. Identities = 13/31 (41%), Positives = 19/31 (61%) Query: 18 LIGGGISGLAAAKLLSEYKINVLVLEARDRV 48 +IGGG S A L++Y +V VL RD++ Sbjct: 163 VIGGGDSAAEEAMFLAKYGSSVTVLVRRDKL 193 >5X6R-A nrPDB Length = 420 Score = 32.1 bits (71), Expect = 0.55, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 24/46 (52%), Gaps = 2/46 (4%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVK 61 V +IG G+ G AA S+ NV + + R R T +N+++K Sbjct: 31 VAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDP--RLDTTKNKNLK 74 >1YQZ-A nrPDB Length = 438 Score = 32.1 bits (71), Expect = 0.61, Method: Composition-based stats. Identities = 10/54 (18%), Positives = 23/54 (42%), Gaps = 6/54 (11%) Query: 1 MTDLEKPN------LAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRV 48 + +LE + A + V ++G G L + L E ++ ++ D++ Sbjct: 130 LRNLEDTDAIDQFIKANQVDKVLVVGAGYVSLEVLENLYERGLHPTLIHRSDKI 183 >4Z25-A nrPDB Length = 652 Score = 31.7 bits (70), Expect = 0.74, Method: Composition-based stats. Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 4/42 (9%) Query: 6 KPNLAGHMFDVGLIGGGISG-LAAAKLLSEYKINVLVLEARD 46 K NL G D+ +IG G +G L A L + +++LEA Sbjct: 2 KDNLTG---DIVIIGAGAAGSLLAHYLARFSNMKIILLEAGH 40 >5W4C-A nrPDB Length = 371 Score = 31.7 bits (70), Expect = 0.77, Method: Composition-based stats. Identities = 14/56 (25%), Positives = 22/56 (39%), Gaps = 5/56 (8%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEA----RDRVGGRTYTVRN-EHVKWVDVG 66 V +IG G G AA L+ + ++ E GG+ T + E+ G Sbjct: 33 VVIIGSGPGGHTAAIYLARANLEPVLYEGMLANGFAPGGQLTTTTDVENFPGFPEG 88 >2NVK-X nrPDB Length = 488 Score = 31.7 bits (70), Expect = 0.81, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 17/30 (56%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLE 43 +D+ +IGGG +GLA AK V L+ Sbjct: 10 YDLIVIGGGSAGLACAKEAVLNGARVACLD 39 Score = 29.8 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 15/81 (18%), Positives = 27/81 (33%), Gaps = 7/81 (8%) Query: 8 NLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGG 67 +L ++G G GL A L V+ R+ +R + ++ Sbjct: 182 SLDREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMV-------RSIVLRGFDQQMAELVA 234 Query: 68 AYVGPTQNRILRLSKELGIET 88 A + LR + L +E Sbjct: 235 ASMEERGIPFLRKTVPLSVEK 255 >5ER0-A nrPDB Length = 518 Score = 31.7 bits (70), Expect = 0.85, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 17/33 (51%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRV 48 + +IG G G A+ S +V +++A RV Sbjct: 200 ITVIGAGYIGAELAEAYSTTGHDVTLIDAMARV 232 >4XDY-A nrPDB Length = 338 Score = 31.3 bits (69), Expect = 0.94, Method: Composition-based stats. Identities = 14/84 (16%), Positives = 30/84 (35%), Gaps = 3/84 (3%) Query: 1 MTDLEKPNLAGHMFD---VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRN 57 M L ++ + + ++G G G A A L + INV++ E G + + Sbjct: 1 MEILHDEDVDDSILRDKTIAVMGYGAQGDAQANCLKDSGINVVIGETEILGGNKNPSWEK 60 Query: 58 EHVKWVDVGGAYVGPTQNRILRLS 81 +V + ++ + Sbjct: 61 AKEDGFEVLPIDKAAEKGDVVHIL 84 >2WOP-A nrPDB Length = 562 Score = 31.3 bits (69), Expect = 1.00, Method: Composition-based stats. Identities = 20/93 (21%), Positives = 33/93 (35%), Gaps = 14/93 (15%) Query: 22 GISGLAAAKLLSEY-KINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPT-QNRILR 79 G +GL A L+E E D GGRT+T R D G ++ + R Sbjct: 75 GPAGLVPAPDLAEGPG------EVSD--GGRTWTYRLRRGLRYDDGTPITSDDVRHAVQR 126 Query: 80 LSKELGIETYKVNVNERLVQYVKGKTYPFRGAF 112 + + + L+ + P+ G + Sbjct: 127 VFAQDVLPGGPT----YLIPLLDDPERPYPGPY 155 >5X68-A nrPDB Length = 391 Score = 31.3 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 23/134 (17%), Positives = 47/134 (35%), Gaps = 8/134 (5%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQN 75 V +IGGG+ G A L++ + V EAR+ R T + + A + Sbjct: 17 VAVIGGGLVGSLQACFLAKRNFQIDVYEAREDT--RVATFT----RGRSINLALSHRGRQ 70 Query: 76 RILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMG 135 + + E I + + + R++ + GK + + + NL + + Sbjct: 71 ALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIP--YGTKSQYILSVSRENLNKDLLTAA 128 Query: 136 KEIPVDAPWQARHA 149 ++ P Sbjct: 129 EKYPNVKMHFNHRL 142 >3IC9-A nrPDB Length = 492 Score = 31.3 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 9/30 (30%), Positives = 18/30 (60%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVLEA 44 DV +IG G +G+ A + ++ V+++E Sbjct: 10 DVAIIGTGTAGMGAYRAAKKHTDKVVLIEG 39 >2YR5-A nrPDB Length = 721 Score = 30.9 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 22/116 (18%), Positives = 43/116 (37%), Gaps = 16/116 (13%) Query: 391 HYEEKNWCEEQYSGGCYTAYFPPGI------MTQYGRVIRQPVGRIYFAGTETATQWSGY 444 +W + +GG + + + + +F +++ + G+ Sbjct: 602 DRFVFDWTTNKTAGG-FKLDMTGDHHQSNLCFRYHTHALAASLDNRFFIASDSYSHLGGW 660 Query: 445 MEGAVEAGE--------RAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLE 492 +EGA + RA R ++AL A+ + P K VPA E+ + LE Sbjct: 661 LEGAFMSALNAVAGLIVRANRGDVSALSTEARPLVIGLRPVVK-VPAAELATSQLE 715 >5X1Y-B nrPDB Length = 554 Score = 30.9 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 21/37 (56%), Gaps = 1/37 (2%) Query: 14 FDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 50 +D+ +IG G + ++A EY V ++E R VGG Sbjct: 85 YDLLIIGSGAAAFSSAIKAIEYGAKVGMIE-RGTVGG 120 >3G5Q-A nrPDB Length = 443 Score = 30.6 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 17/33 (51%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVLEAR 45 M V ++G G++G AA L + V + E R Sbjct: 1 MERVNVVGAGLAGSEAAWTLLRLGVPVRLFEMR 33 >4MIF-A nrPDB Length = 620 Score = 30.6 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 33/128 (25%), Positives = 54/128 (42%), Gaps = 11/128 (8%) Query: 7 PNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLE--ARDRVGGRTYTVRNEHVKWVD 64 P A +DV + G G G AKL + + V ++E A D ++T + Sbjct: 7 PFRADEPYDVFIAGSGPIGATFAKLCVDANLRVCMVEIGAAD-----SFTSKPMKGDPNA 61 Query: 65 VGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDY 124 GP Q I K+ IE Y+ +++ R V +KG + P N +A LD Sbjct: 62 PRSVQFGPGQVPIPGYHKKNEIE-YQKDID-RFVNVIKGAL--STCSIPTSNNHIATLDP 117 Query: 125 NNLWRTMD 132 + + ++D Sbjct: 118 SVVSNSLD 125 >3IP1-A nrPDB Length = 404 Score = 30.6 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 10/28 (35%), Positives = 17/28 (60%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVL 42 +V ++GGG GLAA +L + ++L Sbjct: 216 NVVILGGGPIGLAAVAILKHAGASKVIL 243 >2XVH-A nrPDB Length = 464 Score = 30.6 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 21/121 (17%), Positives = 40/121 (33%), Gaps = 21/121 (17%) Query: 184 SEPHEVSALWFLWYV--RQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDK---- 237 EP S +LW ++C A + G+ + + I G + Sbjct: 59 GEPVHSSMYRYLWSNGPKECLEFADYTFDEHFGKPIASYPPREVLWDYIKGRVEKAGVRK 118 Query: 238 -VKLSSPVTYIDQTDDN--IIVETLNHE-----HYECKYVISAIPPILTAKIHFKPELPP 289 ++ ++ V +++ +D+ V +H E YV+ HF P Sbjct: 119 YIRFNTAVRHVEFNEDSQTFTVTVQDHTTDTIYSEEFDYVVCCTG-------HFSTPYVP 171 Query: 290 E 290 E Sbjct: 172 E 172 >4Z2R-A nrPDB Length = 592 Score = 30.6 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 10/28 (35%), Positives = 17/28 (60%) Query: 15 DVGLIGGGISGLAAAKLLSEYKINVLVL 42 DV ++G G +G +A LL+ I L++ Sbjct: 14 DVLIVGAGPAGAMSATLLASLGIRSLMI 41 >4P5A-A nrPDB Length = 239 Score = 30.2 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 17/62 (27%), Positives = 28/62 (45%) Query: 51 RTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRG 110 RT++ E ++ +VG A+ P R+LR + G Y + Q V+ T + Sbjct: 88 RTWSFNEESARYREVGAAFYVPDATRLLRQEGKPGDYRYVGGSTDDHQQVVRSATRAYEV 147 Query: 111 AF 112 AF Sbjct: 148 AF 149 >3CUK-A nrPDB Length = 347 Score = 30.2 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 10/25 (40%), Positives = 15/25 (60%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVL 40 V +IG G+ GL+ A + E +VL Sbjct: 3 VVVIGAGVIGLSTALCIHERYHSVL 27 >1VE9-A nrPDB Length = 347 Score = 30.2 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 10/25 (40%), Positives = 15/25 (60%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVL 40 V +IG G+ GL+ A + E +VL Sbjct: 3 VVVIGAGVIGLSTALCIHERYHSVL 27 >5VT6-A nrPDB Length = 269 Score = 30.2 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 14/47 (29%), Positives = 23/47 (48%), Gaps = 12/47 (25%) Query: 16 VGLIGGGISGLAAA--KLLSEYKINVLVLEARDRVGGRTYTVRNEHV 60 V + GG+ GL AA + L + + V V +++ RN+HV Sbjct: 27 VAFVTGGMGGLGAAISRRLHDAGMAVAV----------SHSERNDHV 63 >6HRD-A nrPDB Length = 317 Score = 29.8 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 23/52 (44%), Gaps = 6/52 (11%) Query: 12 HMFDVG----LIGGGISGLAAAKLLSEYKINVLVLEARDRV--GGRTYTVRN 57 HM D ++G G G A++ + + V V E + + GR V++ Sbjct: 20 HMSDAIQRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEALITAGRNRIVKS 71 >2YVG-A nrPDB Length = 408 Score = 29.8 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 19/37 (51%) Query: 17 GLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTY 53 ++GGG+ GL A ++V ++E + R+ R Sbjct: 149 LIVGGGVIGLELAATARTAGVHVSLVETQPRLMSRAA 185 >5EVY-X nrPDB Length = 438 Score = 29.8 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 14/36 (38%), Positives = 19/36 (52%), Gaps = 1/36 (2%) Query: 9 LAGHMFDVGLIGGGISGLAAAKLLSEYKI-NVLVLE 43 + V +IGGGI+G A A LS+ NV + E Sbjct: 18 KSKSPLRVAVIGGGIAGTALALGLSKSSHVNVKLFE 53 >4UDQ-A nrPDB Length = 531 Score = 29.4 bits (64), Expect = 4.0, Method: Composition-based stats. Identities = 14/33 (42%), Positives = 20/33 (60%), Gaps = 1/33 (3%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKIN-VLVLEA 44 +FD ++GGG +G A LS N VL++EA Sbjct: 5 IFDYVIVGGGTAGSVLANRLSARPENRVLLIEA 37 >3GGO-A nrPDB Length = 314 Score = 29.4 bits (64), Expect = 4.0, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 17/38 (44%) Query: 1 MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKIN 38 M ++ K + M +V ++G G G + AK L Sbjct: 21 MKNIIKILKSLSMQNVLIVGVGFMGGSFAKSLRRSGFK 58 >5I68-A nrPDB Length = 663 Score = 29.4 bits (64), Expect = 4.3, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 22/35 (62%), Gaps = 2/35 (5%) Query: 14 FDVGLIGGGISGLAAAKLLS--EYKINVLVLEARD 46 FD+ ++GGG SG A L+ ++ + V ++EA + Sbjct: 7 FDILVLGGGSSGSCIAGRLANLDHSLKVGLIEAGE 41 >1XLT-A nrPDB Length = 384 Score = 29.0 bits (63), Expect = 4.6, Method: Composition-based stats. Identities = 19/64 (29%), Positives = 29/64 (45%), Gaps = 7/64 (10%) Query: 13 MFDVGLIGGGISGLAA---AKLLSEYKINVLVLEAR----DRVGGRTYTVRNEHVKWVDV 65 V + G G++GL A AK L + V A + +GG+ TV +E +K + Sbjct: 172 PARVLVFGVGVAGLQAIATAKRLGAVVMATDVRAATKEQVESLGGKFITVDDEAMKTAET 231 Query: 66 GGAY 69 G Y Sbjct: 232 AGGY 235 >3MOG-A nrPDB Length = 483 Score = 29.0 bits (63), Expect = 5.3, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 15/28 (53%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLE 43 V +IG G G A++ + + VL+ + Sbjct: 8 VAVIGSGTMGAGIAEVAASHGHQVLLYD 35 >3CP2-A nrPDB Length = 649 Score = 28.6 bits (62), Expect = 6.2, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 16/30 (53%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVL 42 FDV +IGGG +G AA + L+L Sbjct: 26 PFDVIIIGGGHAGTEAAMAAARMGQQTLLL 55 >3G05-A nrPDB Length = 576 Score = 28.6 bits (62), Expect = 6.5, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 16/30 (53%) Query: 13 MFDVGLIGGGISGLAAAKLLSEYKINVLVL 42 FDV +IGGG +G AA + L+L Sbjct: 32 PFDVIIIGGGHAGTEAAMAAARMGQQTLLL 61 >2QA1-A nrPDB Length = 500 Score = 28.3 bits (61), Expect = 8.1, Method: Composition-based stats. Identities = 6/21 (28%), Positives = 10/21 (47%) Query: 16 VGLIGGGISGLAAAKLLSEYK 36 V ++G G +G+ A L Sbjct: 14 VIVVGAGPAGMMLAGELRLAG 34 >4TSK-A nrPDB Length = 350 Score = 28.3 bits (61), Expect = 8.8, Method: Composition-based stats. Identities = 12/51 (23%), Positives = 22/51 (43%), Gaps = 3/51 (5%) Query: 16 VGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVG 66 + +IG G G A A+ L + +V++ R G + + + VG Sbjct: 20 IAVIGYGSQGHAHAQNLRDSGFDVVI---GLRPGSSWAKAEADGFRVMAVG 67 >4BK3-A nrPDB Length = 424 Score = 28.3 bits (61), Expect = 9.0, Method: Composition-based stats. Identities = 8/37 (21%), Positives = 13/37 (35%) Query: 231 MGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECK 267 G ++ VT + D IV T + +E Sbjct: 121 ARAAGAELHTGVTVTDVITEGDKAIVSTDDGRTHEAD 157 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.121 0.291 Lambda K H 0.267 0.0370 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,380,010 Number of Sequences: 36641 Number of extensions: 689195 Number of successful extensions: 2766 Number of sequences better than 10.0: 270 Number of HSP's better than 10.0 without gapping: 294 Number of HSP's successfully gapped in prelim test: 72 Number of HSP's that attempted gapping in prelim test: 2217 Number of HSP's gapped (non-prelim): 504 length of query: 526 length of database: 10,336,785 effective HSP length: 102 effective length of query: 424 effective length of database: 6,599,403 effective search space: 2798146872 effective search space used: 2798146872 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.3 bits)