BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P21375 (501 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5ZYN-B nrPDB 966 0.0 1QO8-A nrPDB 213 1e-55 1KSU-A nrPDB 207 9e-54 1D4E-A nrPDB 201 5e-52 5KXJ-A nrPDB 102 5e-22 1KNR-A nrPDB 97 1e-20 2H88-A nrPDB 96 4e-20 4YTP-A nrPDB 92 5e-19 3VR8-A nrPDB 87 2e-17 2E5V-A nrPDB 85 6e-17 2B76-A nrPDB 84 1e-16 2WDR-A nrPDB 66 3e-11 5XMJ-A nrPDB 60 2e-09 2BS2-A nrPDB 54 1e-07 5BR7-A nrPDB 39 0.004 4RPJ-A nrPDB 37 0.025 1O5W-A nrPDB 35 0.077 5EQD-A nrPDB 35 0.10 2ZJ8-A nrPDB 33 0.28 2BXR-A nrPDB 32 0.66 1QT1-A nrPDB 32 0.66 4RG3-A nrPDB 32 0.75 5MKK-A nrPDB 32 0.87 2GMH-A nrPDB 31 1.2 4IVM-B nrPDB 31 1.3 6A37-A nrPDB 31 1.3 5MOG-A nrPDB 31 1.4 4YNU-A nrPDB 30 2.1 3ABT-A nrPDB 30 2.8 4ZCC-A nrPDB 30 3.0 1I8T-A nrPDB 30 3.4 5KOI-A nrPDB 29 3.7 6ER9-A nrPDB 29 3.9 3L1R-A nrPDB 29 4.5 3BI4-A nrPDB 29 4.6 5L3D-A nrPDB 29 4.6 5EZ7-A nrPDB 29 5.5 3KKJ-A nrPDB 28 6.6 2AK2-A nrPDB 28 7.2 4FX9-A nrPDB 28 8.3 2C9Y-A nrPDB 28 8.4 >5ZYN-B nrPDB Length = 471 Score = 966 bits (2497), Expect = 0.0, Method: Compositional matrix adjust. Identities = 470/470 (100%), Positives = 470/470 (100%) Query: 32 SMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQN 91 SMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQN Sbjct: 2 SMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQN 61 Query: 92 LKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHSV 151 LKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHSV Sbjct: 62 LKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHSV 121 Query: 152 PRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYM 211 PRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYM Sbjct: 122 PRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYM 181 Query: 212 DENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAE 271 DENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAE Sbjct: 182 DENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAE 241 Query: 272 LIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTM 331 LIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTM Sbjct: 242 LIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTM 301 Query: 332 EIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELV 391 EIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELV Sbjct: 302 EIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELV 361 Query: 392 TELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIK 451 TELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIK Sbjct: 362 TELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIK 421 Query: 452 KNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIAKLY 501 KNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIAKLY Sbjct: 422 KNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIAKLY 471 >1QO8-A nrPDB Length = 566 Score = 213 bits (543), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 157/489 (32%), Positives = 250/489 (51%), Gaps = 46/489 (9%) Query: 20 VLKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASS 79 + K +G +T+ V+V+G+G AG S K V+L+DKA GGNS+ ++ Sbjct: 110 IQKAIAAGPSETTQ---VLVVGAGSAGFNAS-LAAKKAGANVILVDKAPFSGGNSMISAG 165 Query: 80 GINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLK 139 G+N T Q V D E F++D + + + L+ L ++S ++WL++ Sbjct: 166 GMNAVGTKQQTAHGVEDKVEWFIEDAMKGGRQQNDIKLVTILAEQSADGVQWLES-LGAN 224 Query: 140 LDLLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIEL 199 LD L + GG V RTHR G G EI+ L K K+ + LNS VV + + Sbjct: 225 LDDLKRSGGARVDRTHRPHGGKSSGPEIIDTLRKAAKEQG------IDTRLNSRVVKLVV 278 Query: 200 DNQGHVTGVVYMDENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTG 259 ++ V G V ++ ++ + VV +GG+G +KEM+ Y P + + ++N TG Sbjct: 279 NDDHSVVGAVVHGKHTGYYMIGAKSVVLATGGYGMNKEMIAYYRPTMKDMTSSNNITATG 338 Query: 260 DGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRF 319 DG + ++GA + D+D VQ HPT D + L +E +RG+G ++++ G RF Sbjct: 339 DGVLMAKEIGASMTDIDWVQAHPTVGKDS-------RILISETVRGVGAVMVN-KDGNRF 390 Query: 320 TNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIR 379 +EL+TRD + I K P A ++ +++Y+ + + L K ++ L + Sbjct: 391 ISELTTRDKASDAIL-KQPG--QFAWIIFDNQLYKKAKMVRGYDHLEMLYKGDTVEQLAK 447 Query: 380 QYDLQTTASELVTELKSYSDVN-----TKDT----FDRPLIINAFDKDISTESTVYVGEV 430 +T ++ K+ SD N KDT D PL + T+S Y +V Sbjct: 448 -----STGMKVADLAKTVSDYNGYVASGKDTAFGRADMPLNM--------TQSPYYAVKV 494 Query: 431 TPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFG 490 P +H TMGGV IN + V+ S+ + +G+FAAGEV+GGVHG NRLGG+++ + VVFG Sbjct: 495 APGIHHTMGGVAINTTASVLDLQSKPI--DGLFAAGEVTGGVHGYNRLGGNAIADTVVFG 552 Query: 491 KTAADNIAK 499 + A DN AK Sbjct: 553 RIAGDNAAK 561 >1KSU-A nrPDB Length = 571 Score = 207 bits (527), Expect = 9e-54, Method: Compositional matrix adjust. Identities = 141/443 (31%), Positives = 239/443 (53%), Gaps = 32/443 (7%) Query: 61 VVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDK 120 V+L++K IGGN+ A+ G+N A TD Q+ K+ D+PEL +DT+ + P+L+ Sbjct: 152 VILIEKEPVIGGNAKLAAGGMNAAWTDQQKAKKITDSPELMFEDTMKGGQNINDPALVKV 211 Query: 121 LTKESKSAIRWLQTEFDLKLDLLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISS 180 L+ SK ++ W+ T L + +GG SV R HR +G G +VQ L D + Sbjct: 212 LSSHSKDSVDWM-TAMGADLTDVGMMGGASVNRAHRPTGGAGVGAHVVQVLY----DNAV 266 Query: 181 KDSNLVQIMLNSEVVDIELDNQGHVTGVVYMDENGNRKIMKSHHVVFCSGGFGYSKEMLK 240 K + + + +N+ +++ D++G V G++ +K+ V+ +GGF + E + Sbjct: 267 KRN--IDLRMNTRGIEVLKDDKGTVKGILVKGMYKGYYWVKADAVILATGGFAKNNERVA 324 Query: 241 EYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAA 300 + P+L +TN GDG + G L DM +Q HPT + + Sbjct: 325 KLDPSLKGFISTNQPGAVGDGLDVAENAGGALKDMQYIQAHPTLSVKGG-------VMVT 377 Query: 301 EALRGLGGILLHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNI 360 EA+RG G IL++ G+RF NE++TRD + I ++ K+ A L+ D V ++ + I Sbjct: 378 EAVRGNGAILVN-REGKRFVNEITTRDKASAAILAQTGKS---AYLIFDDSVRKSLS-KI 432 Query: 361 NFYMSKNLIKKVSINDLIRQYDLQTTASELVTE-LKSYSDV--NTKDT-FDRPLIINAFD 416 + Y+ + + + L++ ++ + +TE + Y+ + + KDT F+RP + A + Sbjct: 433 DKYIGLGVAP--TADSLVKLGKMEGIDGKALTETVARYNSLVSSGKDTDFERPNLPRALN 490 Query: 417 KDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGAN 476 E Y EVTP VH+TMGGV I+ K++V+ N++ + G++ AGEV+GGVHGAN Sbjct: 491 -----EGNYYAIEVTPGVHYTMGGVMIDTKAEVM--NAKKQVIPGLYGAGEVTGGVHGAN 543 Query: 477 RLGGSSLLECVVFGKTAADNIAK 499 RLGG+++ + + FG+ A + AK Sbjct: 544 RLGGNAISDIITFGRLAGEEAAK 566 >1D4E-A nrPDB Length = 572 Score = 201 bits (512), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 148/447 (33%), Positives = 227/447 (50%), Gaps = 37/447 (8%) Query: 61 VVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDK 120 V+LL+K GGN+ A+ G+N A T Q L + D ++ + DT+ + P L+ Sbjct: 152 VILLEKEPIPGGNTKLAAGGMNAAETKPQAKLGIEDKKQIMIDDTMKGGRNINDPELVKV 211 Query: 121 LTKESKSAIRWLQTEFDLKLDLLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISS 180 L S +I WL T + + ++GG SV R+HR +G G + Q L D + Sbjct: 212 LANNSSDSIDWL-TSMGADMTDVGRMGGASVNRSHRPTGGAGVGAHVAQVLW----DNAV 266 Query: 181 KDSNLVQIMLNSEVVDIELDNQGHVTGVVYMDENGNRKIMKSHHVVFCSGGFGYSKEMLK 240 K I LNS VV I D G VTGV+ E ++K+ VV +GGF + E + Sbjct: 267 KRG--TDIRLNSRVVRILEDASGKVTGVLVKGEYTGYYVIKADAVVIAAGGFAKNNERVS 324 Query: 241 EYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAA 300 +Y P L TN TGDG + + GA D+ +Q HPT + Sbjct: 325 KYDPKLKGFKATNHPGATGDGLDVALQAGAATRDLQYIQAHPT-------YSPAGGVMIT 377 Query: 301 EALRGLGGILLHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNI 360 EA+RG G I+++ G RF NE++TRD + I + A LV D + ++ I Sbjct: 378 EAVRGNGAIVVN-REGNRFMNEITTRDKASAAILQ---QKGESAYLVFDDSIRKSL-KAI 432 Query: 361 NFYMSKNLIKK-VSINDLIRQYDLQTTASELVTELKSYSDV--NTKDT-FDRPLIINAFD 416 Y+ N++K+ +I +L +Q D+ A+EL + +Y+ + KD F+RP Sbjct: 433 EGYVHLNIVKEGKTIEELAKQIDV--PAAELAKTVTAYNGFVKSGKDAQFERP------- 483 Query: 417 KDISTESTV---YVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVH 473 D+ E V Y E+ P VH TMGG+ I+ K++V + + ++ G++AAGEV+GGVH Sbjct: 484 -DLPRELVVAPFYALEIAPAVHHTMGGLVIDTKAEVKSEKTAKPIT-GLYAAGEVTGGVH 541 Query: 474 GANRLGGSSLLECVVFGKTAADNIAKL 500 GANRLGG+++ + V +G+ A + AK Sbjct: 542 GANRLGGNAISDIVTYGRIAGASAAKF 568 >5KXJ-A nrPDB Length = 557 Score = 102 bits (253), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 119/483 (24%), Positives = 203/483 (42%), Gaps = 105/483 (21%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMD 96 V++IGSG AGL+ + RL K++ V++L K G++ A GI +T D Sbjct: 11 VLIIGSGAAGLSLALRLAEKHK--VIVLSKGPVSEGSTFYAQGGIAAVFDET-------D 61 Query: 97 TPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTE---FDLKLDL-------LAQL 146 + ++DTL + G ++ + +++ ++WL + FD + L + Sbjct: 62 SIASHVEDTLIAGAGICDRHAVEFVASNARTCVQWLIDQGVLFDTHVQPNGKESYHLTRE 121 Query: 147 GGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVT 206 GGHS R ++ G E+ L + ++ + +Q++ S VD+ + ++ + Sbjct: 122 GGHSHRRILHAADAT--GKEVETTLVSRAQNHPN-----IQVLERSNAVDLIISDKMGLP 174 Query: 207 G----VVYMDENGNRKIMKSHH---VVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTG 259 G V N N++ +++ H VV +GG + ++ TTN ++G Sbjct: 175 GPRRVVGAWIWNRNKEWVETCHAKSVVLATGG------------ASKVYQYTTNPDISSG 222 Query: 260 DGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRF 319 DG + + G + +++ Q HPT P R FL EALRG G L P G RF Sbjct: 223 DGIAMAWRAGCRVANLEFNQFHPTALYHPQAR----NFLLTEALRGEGAYLKRP-DGSRF 277 Query: 320 TNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVS--INDL 377 P D R L D V + + + + +S +D Sbjct: 278 M-----------------PDVDERGELAPRDIVARAIDHEMKQLGADCMFLDISHKPDDF 320 Query: 378 IRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFT 437 +RQ+ A L D+ + T V P H+T Sbjct: 321 VRQHFPMIYAKLL---------------------------DLGMDLTKEPIPVVPAAHYT 353 Query: 438 MGGVKINEKSQVIKKNSESVLSNGIFAAGEVS-GGVHGANRLGGSSLLECVVFGKTAADN 496 GGV +++ + +G++A GEVS G+HGANR+ +SLLEC+V+G +AA + Sbjct: 354 CGGVVVDDYGRTD--------VDGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAMD 405 Query: 497 IAK 499 I + Sbjct: 406 IDR 408 >1KNR-A nrPDB Length = 540 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 122/486 (25%), Positives = 203/486 (41%), Gaps = 111/486 (22%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMD 96 V++IGSG AGL+ + RL +++ V++L K G++ A GI +T D Sbjct: 11 VLIIGSGAAGLSLALRLADQHQ--VIVLSKGPVTEGSTFYAQGGIAAVFDET-------D 61 Query: 97 TPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTE---FDLKLDL-------LAQL 146 + + ++DTL + G ++ + ++S ++WL + FD + L + Sbjct: 62 SIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTRE 121 Query: 147 GGHSVPRTHRSSGKLPPGFEIVQAL-SKKLKDISSK---DSNLVQIMLNSEVVDIELDNQ 202 GGHS R ++ G E+ L SK L + + +N V ++++ + I L Sbjct: 122 GGHSHRRILHAADAT--GREVETTLVSKALNHPNIRVLERTNAVDLIVSDK---IGLPGT 176 Query: 203 GHVTGVVYMDENGNRKIMKSHH---VVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTG 259 V G N N++ +++ H VV +GG + +Y TTN ++G Sbjct: 177 RRVVGAWVW--NRNKETVETCHAKAVVLATGG----ASKVYQY--------TTNPDISSG 222 Query: 260 DGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRF 319 DG + + G + +++ Q HPT P R FL EALRG G L P G RF Sbjct: 223 DGIAMAWRAGCRVANLEFNQFHPTALYHPQAR----NFLLTEALRGEGAYLKRP-DGTRF 277 Query: 320 TNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSIN--DL 377 P D R L D V + + + + +S D Sbjct: 278 M-----------------PDFDERGELAPRDIVARAIDHEMKRLGADCMFLDISHKPADF 320 Query: 378 IRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIIN---AFDKDISTESTVYVGEVTPVV 434 IRQ+ P+I D++ E + P Sbjct: 321 IRQH--------------------------FPMIYEKLLGLGIDLTQEPV----PIVPAA 350 Query: 435 HFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVS-GGVHGANRLGGSSLLECVVFGKTA 493 H+T GGV +++ + + G++A GEVS G+HGAN + +SLLEC+V+G +A Sbjct: 351 HYTCGGVMVDDHGRTDVE--------GLYAIGEVSYTGLHGANLMASNSLLECLVYGWSA 402 Query: 494 ADNIAK 499 A++I + Sbjct: 403 AEDITR 408 >2H88-A nrPDB Length = 621 Score = 95.9 bits (237), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 92/320 (28%), Positives = 140/320 (43%), Gaps = 81/320 (25%) Query: 194 VVDIELDNQGHVTGVVYMD-ENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTT 252 +D+ ++N G GV+ + E+G ++ + V +GG+G + + T Sbjct: 178 ALDLLMEN-GECRGVIALCIEDGTIHRFRAKNTVIATGGYGRT------------YFSCT 224 Query: 253 NGKQTTGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLH 312 + +TGDG ++++ G D++ VQ HPTG L E RG GGIL++ Sbjct: 225 SAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIYGAG-------CLITEGCRGEGGILIN 277 Query: 313 PTTGRRF-------TNELSTRDTV----TMEIQSKCPKNDNRALLVMSDKVYENYTNNIN 361 + G RF +L++RD V T+EI+ + R D VY Sbjct: 278 -SQGERFMERYAPVAKDLASRDVVSRSMTIEIR------EGRGCGPEKDHVY-------- 322 Query: 362 FYMSKNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDIST 421 + ++ L Q +L T L S+ +I D ++ Sbjct: 323 ----------LQLHHLPPQ--------QLATRLPGISET--------AMIFAGVD--VTK 354 Query: 422 ESTVYVGEVTPVVHFTMGGVKINEKSQVIKK-NSESVLSNGIFAAGEV-SGGVHGANRLG 479 E V P VH+ MGG+ N K QVI N E + G++A GE S VHGANRLG Sbjct: 355 EPI----PVLPTVHYNMGGIPTNYKGQVITHVNGEDKVVPGLYACGEAASASVHGANRLG 410 Query: 480 GSSLLECVVFGKTAADNIAK 499 +SLL+ VVFG+ A IA+ Sbjct: 411 ANSLLDLVVFGRACALTIAE 430 >4YTP-A nrPDB Length = 664 Score = 92.0 bits (227), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 87/320 (27%), Positives = 142/320 (44%), Gaps = 81/320 (25%) Query: 194 VVDIELDNQGHVTGVVYMD-ENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTT 252 +D+ ++N G GV+ + E+G+ +++ + V +GG+G + + T Sbjct: 221 ALDLLMEN-GECRGVIALCIEDGSIHRIRARNTVVATGGYGRT------------YFSCT 267 Query: 253 NGKQTTGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLH 312 + +TGDG ++++ G D++ VQ HPTG L E RG GGIL++ Sbjct: 268 SAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIYGAG-------CLITEGCRGEGGILIN 320 Query: 313 PTTGRRF-------TNELSTRDTV----TMEIQSKCPKNDNRALLVMSDKVYENYTNNIN 361 + G RF +L++RD V T+EI+ + R D VY Sbjct: 321 -SQGERFMERYAPVAKDLASRDVVSRSMTLEIR------EGRGCGPEKDHVY-------- 365 Query: 362 FYMSKNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDIST 421 + ++ L +L L S+ +I D ++ Sbjct: 366 ----------LQLHHL--------PPEQLAVRLPGISET--------AMIFAGVD--VTK 397 Query: 422 ESTVYVGEVTPVVHFTMGGVKINEKSQVIKK-NSESVLSNGIFAAGEVS-GGVHGANRLG 479 E V P VH+ MGG+ N K QV++ N + + G++A GE + VHGANRLG Sbjct: 398 EPI----PVLPTVHYNMGGIPTNYKGQVLRHVNGQDQVVPGLYACGEAACASVHGANRLG 453 Query: 480 GSSLLECVVFGKTAADNIAK 499 +SLL+ VVFG+ A +IA+ Sbjct: 454 ANSLLDLVVFGRACALSIAE 473 >3VR8-A nrPDB Length = 645 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 87/314 (27%), Positives = 132/314 (42%), Gaps = 81/314 (25%) Query: 199 LDNQGHVTGVVYMD-ENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQT 257 L ++G GV+ + E+G +S + +GG+G + + T Sbjct: 205 LMDKGRCVGVIALCLEDGTIHRFRSKRTIVATGGYGRA------------YFSCTTAHMN 252 Query: 258 TGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGR 317 TGDG + ++ G L D++ +Q HPTG L E RG GG L++ + G Sbjct: 253 TGDGTALATRAGIALEDLEFIQFHPTGIYGVG-------CLITEGSRGEGGFLVN-SEGE 304 Query: 318 RF-------TNELSTRDTV----TMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSK 366 RF +L++RD V T+EI + R + D +Y Sbjct: 305 RFMERYAPKAKDLASRDVVSRAETIEIM------EGRGVGPEKDHIY------------- 345 Query: 367 NLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVY 426 + ++ L A +L L S+ T F D++ E Sbjct: 346 -----LQLHHL--------PAEQLHQRLPGISE--TAKIFA--------GVDVTKEPI-- 380 Query: 427 VGEVTPVVHFTMGGVKINEKSQVIKKNSES--VLSNGIFAAGEVSG-GVHGANRLGGSSL 483 V P VH+ MGG+ N K+QVIK E + G++A GE + VHGANRLG +SL Sbjct: 381 --PVIPTVHYNMGGIPTNYKAQVIKYTKEGGDKIVPGLYACGECACHSVHGANRLGANSL 438 Query: 484 LECVVFGKTAADNI 497 L+ VVFG+ + NI Sbjct: 439 LDAVVFGRACSINI 452 >2E5V-A nrPDB Length = 472 Score = 85.1 bits (209), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 126/461 (27%), Positives = 195/461 (42%), Gaps = 108/461 (23%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMD 96 + +IGSG+AGL+ L + V L+ K GG++ A G+ ++ D Sbjct: 2 IYIIGSGIAGLSAGVAL-RRAGKKVTLISKRID-GGSTPIAKGGV-------AASVGSDD 52 Query: 97 TPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTE-FDLKLDLLAQLGGHSVPRT- 154 +PEL +DT+ G ++ +T E+K+ I ++ F+ + DL + GGH+ R Sbjct: 53 SPELHAQDTIRVGDGLCDVKTVNYVTSEAKNVIETFESWGFEFEEDLRLE-GGHTKRRVL 111 Query: 155 HRSSGKLPPGFEIVQALSKKLKD--ISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMD 212 HR+ G EI L K ++ I + LV+I + G VTG V Sbjct: 112 HRTD---ETGREIFNFLLKLAREEGIPIIEDRLVEIRVK----------DGKVTGFVTEK 158 Query: 213 ENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAEL 272 + K +V +GG+ Y L EYS +TN GDG I K G L Sbjct: 159 RGLVEDVDK---LVLATGGYSY----LYEYSST----QSTN----IGDGMAIAFKAGTIL 203 Query: 273 IDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTME 332 DM+ VQ HPT + D E FL E LRG G +++ G RF R + Sbjct: 204 ADMEFVQFHPT--VTSLDGE---VFLLTETLRGEGAQIINE-NGERFLFNYDKRGEL--- 254 Query: 333 IQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVT 392 P++ ++S +Y E++ Sbjct: 255 ----APRD------ILSRAIY----------------------------------IEMLK 270 Query: 393 ELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVT--PVVHFTMGGVKINEKSQVI 450 K + D++ + F+R + A K ++ Y ++ P HF GG+++N + Sbjct: 271 GHKVFIDLSKIEDFERKFPVVA--KYLARHGHNYKVKIPIFPAAHFVDGGIRVNIR---- 324 Query: 451 KKNSESVLSNGIFAAGEVS-GGVHGANRLGGSSLLECVVFG 490 ES + N ++A GEVS G+HGANRL +SLLE +VFG Sbjct: 325 ---GESNIVN-LYAIGEVSDSGLHGANRLASNSLLEGLVFG 361 >2B76-A nrPDB Length = 602 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 104/357 (29%), Positives = 153/357 (42%), Gaps = 67/357 (18%) Query: 145 QLGGHSVPRTHRSSGKLPPGFEIVQAL---SKKLKDISSKDSNLVQIMLNSEVVDIELDN 201 + GG + RT ++ K GF ++ L S + I D + V +DI +D+ Sbjct: 116 RFGGMKIERTWFAADKT--GFHMLHTLFQTSLQFPQIQRFDEHFV--------LDILVDD 165 Query: 202 QGHVTGVVYMDE-NGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGD 260 GHV G+V M+ G ++++ VV +GG G + Y N TNG TGD Sbjct: 166 -GHVRGLVAMNMMEGTLVQIRANAVVMATGGAG------RVYRYN------TNGGIVTGD 212 Query: 261 GQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFT 320 G + G L DM+ VQ HPTG P L E RG GGIL++ G R+ Sbjct: 213 GMGMALSHGVPLRDMEFVQYHPTGL--PGS-----GILMTEGCRGEGGILVN-KNGYRYL 264 Query: 321 NELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQ 380 + + E PKN L DKV + + + + N I D++ Sbjct: 265 QDYG----MGPETPLGEPKNKYMEL-GPRDKVSQAFWHE---WRKGNTIS-TPRGDVV-Y 314 Query: 381 YDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGG 440 DL+ + + E P I + + V P H+TMGG Sbjct: 315 LDLRHLGEKKLHE-------------RLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGG 361 Query: 441 VKINEKSQVIKKNSESVLSNGIFAAGEVSG-GVHGANRLGGSSLLECVVFGKTAADN 496 ++ ++ N E+ + G+FA GE S G+HGANRLG +SL E VVFG+ A + Sbjct: 362 IETDQ-------NCETRI-KGLFAVGECSSVGLHGANRLGSNSLAELVVFGRLAGEQ 410 >2WDR-A nrPDB Length = 588 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 85/320 (26%), Positives = 128/320 (40%), Gaps = 68/320 (21%) Query: 184 NLVQIMLNSEVVDIELDNQGHVTGVVYMD-ENGNRKIMKSHHVVFCSGGFGYSKEMLKEY 242 N I +D+ + G V G + E G K+ V +GG G Sbjct: 156 NHTTIFSEWYALDLVKNQDGAVVGCTALCIETGEVVYFKARATVLATGGAGR-------- 207 Query: 243 SPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEA 302 I+ TTN TGDG + + G + DM+ Q HPTG L E Sbjct: 208 ----IYQSTTNAHINTGDGVGMAIRAGVPVQDMEMWQFHPTGIAGAG-------VLVTEG 256 Query: 303 LRGLGGILLHPTTGRRF-------TNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYEN 355 RG GG LL+ G RF +L+ RD V I + + D + Sbjct: 257 CRGEGGYLLN-KHGERFMERYAPNAKDLAGRDVVARSIMIEIREGRG------CDGPWGP 309 Query: 356 YTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAF 415 + K+ ++ L ++ L++ ++ ++++ V D P+ + Sbjct: 310 HA-------------KLKLDHLGKEV-LESRLPGILELSRTFAHV---DPVKEPIPV--- 349 Query: 416 DKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSG-GVHG 474 I T + G T V T + +NEK E V+ G+FA GE++ VHG Sbjct: 350 ---IPTCHYMMGGIPTKV---TGQALTVNEK-------GEDVVVPGLFAVGEIACVSVHG 396 Query: 475 ANRLGGSSLLECVVFGKTAA 494 ANRLGG+SLL+ VVFG+ A Sbjct: 397 ANRLGGNSLLDLVVFGRAAG 416 >5XMJ-A nrPDB Length = 627 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 72/256 (28%), Positives = 102/256 (39%), Gaps = 51/256 (19%) Query: 247 IHLPTTNGKQTTGDGQKILSKLG-AELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRG 305 I+ TTN G GQ I G + +M+ VQ HPTG + P D L E RG Sbjct: 222 IYKATTNAVICDGGGQIIALDTGLVPMGNMEAVQFHPTGTV-PTD------ILVTEGCRG 274 Query: 306 LGGILLHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMS 365 GG LL RF + ++A L D V T +M Sbjct: 275 DGGTLLD-VNQYRFMPDYEP----------------DKAQLASRDVVSRRMTE----HMR 313 Query: 366 KNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTV 425 K L K D + + T+L+ D+ T F L +N + I Sbjct: 314 KGLGVKSPYGDHLWLDIRHLGEKHITTKLREVYDICT--NF---LGVNPIHQLIP----- 363 Query: 426 YVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGE-VSGGVHGANRLGGSSLL 484 V P H++MGGV+ N ++ + G+F+AGE +HG NRLGG+SL Sbjct: 364 ----VRPTHHYSMGGVRTN-------RDGAAYGLKGLFSAGESACWDMHGFNRLGGNSLA 412 Query: 485 ECVVFGKTAADNIAKL 500 E VV G+ + + + Sbjct: 413 ETVVAGRYIGERMVEF 428 >2BS2-A nrPDB Length = 660 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 64/262 (24%), Positives = 106/262 (40%), Gaps = 66/262 (25%) Query: 247 IHLPTTNGKQTTGDGQKILSKLG-AELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRG 305 I+ TTN G G I + G A+L +M+ VQ HPT L E RG Sbjct: 222 IYKNTTNAVVCEGTGTAIALETGIAQLGNMEAVQFHPTPLFPSG-------ILLTEGCRG 274 Query: 306 LGGILLHPTTGRRF-------TNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTN 358 GGIL G RF EL++RD V+ + K Sbjct: 275 DGGIL-RDVDGHRFMPDYEPEKKELASRDVVSRRMIEHIRKG-----------------K 316 Query: 359 NINFYMSKNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKD 418 + ++L +SI L R++ ++T ++ + ++ ++ + + Sbjct: 317 GVQSPYGQHLWLDISI--LGRKH-IETNLRDVQEICEYFAGIDPAEKW------------ 361 Query: 419 ISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGG-VHGANR 477 V P+ H++MGG++ + + + K G+F+AGE + +HG NR Sbjct: 362 ---------APVLPMQHYSMGGIRTDYRGEAKLK--------GLFSAGEAACWDMHGFNR 404 Query: 478 LGGSSLLECVVFGKTAADNIAK 499 LGG+S+ E VV G + A+ Sbjct: 405 LGGNSVSEAVVAGMIVGEYFAE 426 >5BR7-A nrPDB Length = 393 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 23/67 (34%), Positives = 38/67 (56%), Gaps = 7/67 (10%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSI---KASSGIN----GAHTDTQ 89 ++V+GSGL GLT + R S+ V++++K + +GGN+ + +GI GAH Sbjct: 6 LIVVGSGLFGLTVAERAASQLGKKVLIVEKRSHLGGNAYSEAEPETGIEIHKYGAHLFHT 65 Query: 90 QNLKVMD 96 N +V D Sbjct: 66 SNKRVWD 72 >4RPJ-A nrPDB Length = 399 Score = 36.6 bits (83), Expect = 0.025, Method: Compositional matrix adjust. Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 7/67 (10%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSI---KASSGIN----GAHTDTQ 89 + V+GSG GLT + R+ ++ V++L++ IGGN+ + +GI GAH Sbjct: 10 LFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGGNAYSEAEPQTGIEVHKYGAHLFHT 69 Query: 90 QNLKVMD 96 N +V D Sbjct: 70 SNKRVWD 76 >1O5W-A nrPDB Length = 534 Score = 35.0 bits (79), Expect = 0.077, Method: Compositional matrix adjust. Identities = 20/61 (32%), Positives = 35/61 (57%), Gaps = 7/61 (11%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASS------GINGAHTDTQQ 90 VVVIG G++GL + +L+S+Y+I V++L+ +GG + + + GA+ Q Sbjct: 24 VVVIGGGISGLAAA-KLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQ 82 Query: 91 N 91 N Sbjct: 83 N 83 >5EQD-A nrPDB Length = 400 Score = 34.7 bits (78), Expect = 0.10, Method: Compositional matrix adjust. Identities = 21/67 (31%), Positives = 35/67 (52%), Gaps = 7/67 (10%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSI---KASSGIN----GAHTDTQ 89 + V+GSG GLT + R ++ V+++++ IGGN+ + +GI GAH Sbjct: 7 LFVVGSGFFGLTIAERAATQLGKRVLVIERRPHIGGNAYSEPEPETGIEVHKYGAHLFHT 66 Query: 90 QNLKVMD 96 N +V D Sbjct: 67 SNKRVWD 73 >2ZJ8-A nrPDB Length = 720 Score = 33.1 bits (74), Expect = 0.28, Method: Compositional matrix adjust. Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 21/117 (17%) Query: 257 TTGDGQKILSKLGAELI--DMDQVQ----VHPTGFIDPND----RENNWKFLAAEALRGL 306 T G+ +++ L AELI D V+ V GF+ D R ++W+ L +A+R Sbjct: 178 TIGNPEELAEWLNAELIVSDWRPVKLRRGVFYQGFVTWEDGSIDRFSSWEELVYDAIRKK 237 Query: 307 GGILLHPTTGRRFTNELSTRDTVTMEIQSKCP----KNDNRALLVMSDKVYENYTNN 359 G L+ F N + V +E+ K K + RAL ++D + EN TN Sbjct: 238 KGALI-------FVNMRRKAERVALELSKKVKSLLTKPEIRALNELADSLEENPTNE 287 >2BXR-A nrPDB Length = 527 Score = 32.0 bits (71), Expect = 0.66, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 35/61 (57%), Gaps = 7/61 (11%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASS------GINGAHTDTQQ 90 VVVIG G++GL+ + +L+++Y + V++L+ +GG + + + GA+ Q Sbjct: 16 VVVIGGGISGLSAA-KLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQ 74 Query: 91 N 91 N Sbjct: 75 N 75 >1QT1-A nrPDB Length = 387 Score = 32.0 bits (71), Expect = 0.66, Method: Compositional matrix adjust. Identities = 23/84 (27%), Positives = 39/84 (46%), Gaps = 12/84 (14%) Query: 21 LKRTLSGTDQTSMKQPVV--------VIGSGLAGLTTSNRLISKY--RIPVVLLDKAASI 70 +KR G D+T MK P+ V G G T ++R + +Y R + +D A + Sbjct: 71 IKRFRQGLDETGMKVPMATTNLFTHPVFKDG--GFTANDRDVRRYALRKTIRNIDLAVEL 128 Query: 71 GGNSIKASSGINGAHTDTQQNLKV 94 G + A G GA + ++++V Sbjct: 129 GAQTYVAWGGREGAESGAAKDVRV 152 >4RG3-A nrPDB Length = 548 Score = 31.6 bits (70), Expect = 0.75, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 36/72 (50%), Gaps = 2/72 (2%) Query: 21 LKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSG 80 L+ ++ T QT+ VVIG+G G+ ++L + + V DKA GG + Sbjct: 3 LEASMHMTAQTTHTVDAVVIGAGFGGIYAVHKLHHELGLTTVGFDKADGPGGTWYW--NR 60 Query: 81 INGAHTDTQQNL 92 GA +DT+ +L Sbjct: 61 YPGALSDTESHL 72 >5MKK-A nrPDB Length = 611 Score = 31.6 bits (70), Expect = 0.87, Method: Compositional matrix adjust. Identities = 33/125 (26%), Positives = 53/125 (42%), Gaps = 18/125 (14%) Query: 89 QQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSA----IRWLQTEF-------D 137 Q+NL ++T +LF+K+ K D+L ++ A IRW F D Sbjct: 216 QENLSGVETIQLFVKEREREEK-------FDRLNRDLFRAWVEIIRWFALFFPVVGFLGD 268 Query: 138 LKLDLLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDI 197 + L GG V R S G L + + L + L+D+S K + M ++E + Sbjct: 269 FAVASLVYYGGGEVVRGAVSLGLLVAFVDYTRQLFQPLQDLSDKFNLFQGAMASAERIFG 328 Query: 198 ELDNQ 202 LD + Sbjct: 329 VLDTE 333 >2GMH-A nrPDB Length = 584 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 16/48 (33%), Positives = 29/48 (60%), Gaps = 5/48 (10%) Query: 37 VVVIGSGLAGLTTSNRLIS-----KYRIPVVLLDKAASIGGNSIKASS 79 VV++G+G AGL+ + RL + + V L++KAA IG +++ + Sbjct: 38 VVIVGAGPAGLSAATRLKQLAAQHEKDLRVCLVEKAAHIGAHTLSGAC 85 >4IVM-B nrPDB Length = 483 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 22/54 (40%), Positives = 33/54 (61%), Gaps = 4/54 (7%) Query: 33 MKQPVVVIGSGLAGLTTSNRLISKYRIP--VVLLDKAASIGGNSIKASSGINGA 84 M + VVV+G G++GL S L S+ P VVL++ + +GG I++ G NGA Sbjct: 7 MGRTVVVLGGGISGLAASYHL-SRAPCPPKVVLVESSERLGGW-IRSVRGPNGA 58 >6A37-A nrPDB Length = 552 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 16/60 (26%), Positives = 30/60 (50%), Gaps = 2/60 (3%) Query: 33 MKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNL 92 M ++IG+G GL + +L + + V D+A +GG + GA +D++ +L Sbjct: 25 MDFDAIIIGAGFGGLYSLKKLRDDFNLKVRAFDRATEVGGTWF--WNQYPGALSDSETHL 82 >5MOG-A nrPDB Length = 497 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 33/68 (48%), Gaps = 2/68 (2%) Query: 21 LKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSG 80 L ++Q + VV+ G+GLAGL+T+ L P++L +A + G I A Sbjct: 4 LSSFFRNSEQPTKPLQVVIAGAGLAGLSTAKYLADAGHKPILL--EARDVLGGKIAAWKD 61 Query: 81 INGAHTDT 88 +G +T Sbjct: 62 EDGDWYET 69 >4YNU-A nrPDB Length = 571 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 22/36 (61%) Query: 38 VVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGN 73 +V+G G +GL +NRL + V+LL+ AS+ N Sbjct: 9 IVVGGGTSGLVVANRLSENPDVSVLLLEAGASVFNN 44 >3ABT-A nrPDB Length = 662 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 24/101 (23%), Positives = 45/101 (44%), Gaps = 14/101 (13%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGN-------------SIKASSGING 83 V++IGSG++GL + +L S + + V LL+ +GG +G+ G Sbjct: 110 VIIIGSGVSGLAAARQLQS-FGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGG 168 Query: 84 AHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKE 124 M+ ++ K L+ A G+ VP D++ ++ Sbjct: 169 NPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQ 209 >4ZCC-A nrPDB Length = 336 Score = 29.6 bits (65), Expect = 3.0, Method: Compositional matrix adjust. Identities = 16/41 (39%), Positives = 23/41 (56%), Gaps = 1/41 (2%) Query: 33 MKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGN 73 M P+ +IG+G+AGL+ + L S V L DK+ GG Sbjct: 1 MTVPIAIIGTGIAGLSAAQALTSAGH-QVHLFDKSRGSGGR 40 >1I8T-A nrPDB Length = 367 Score = 29.6 bits (65), Expect = 3.4, Method: Compositional matrix adjust. Identities = 19/53 (35%), Positives = 29/53 (54%), Gaps = 6/53 (11%) Query: 38 VVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSI-KASSGIN----GAH 85 +++GSGL G +N L K V++++K IGGN+ + GI GAH Sbjct: 5 IIVGSGLFGAVCANEL-KKLNKKVLVIEKRNHIGGNAYTEDCEGIQIHKYGAH 56 >5KOI-A nrPDB Length = 293 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 12/25 (48%), Positives = 19/25 (76%), Gaps = 1/25 (4%) Query: 392 TELKS-YSDVNTKDTFDRPLIINAF 415 TELK Y+DV T++ F R ++I+A+ Sbjct: 120 TELKGRYADVTTRENFSRTMVISAY 144 >6ER9-A nrPDB Length = 549 Score = 29.3 bits (64), Expect = 3.9, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 2/56 (3%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNL 92 VVIG+G G+ ++L ++ + VV DKA GG + GA +DT+ +L Sbjct: 12 AVVIGAGFGGIYAVHKLHNEQGLTVVGFDKADGPGGTWYW--NRYPGALSDTESHL 65 >3L1R-A nrPDB Length = 478 Score = 29.3 bits (64), Expect = 4.5, Method: Compositional matrix adjust. Identities = 15/47 (31%), Positives = 29/47 (61%), Gaps = 1/47 (2%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKAS-SGIN 82 V+V+G+G++G++ + RL +++L+ IGG K + +GIN Sbjct: 7 VIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGIN 53 >3BI4-A nrPDB Length = 516 Score = 29.3 bits (64), Expect = 4.6, Method: Compositional matrix adjust. Identities = 21/79 (26%), Positives = 38/79 (48%), Gaps = 9/79 (11%) Query: 34 KQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGING--------AH 85 K+ V++IG+G+AGL ++ L ++L+ +GG ++ +G G H Sbjct: 8 KKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGR-LQTVTGYQGRKYDIGASWH 66 Query: 86 TDTQQNLKVMDTPELFLKD 104 DT N ++ +L L D Sbjct: 67 HDTLTNPLFLEEAQLSLND 85 >5L3D-A nrPDB Length = 852 Score = 29.3 bits (64), Expect = 4.6, Method: Compositional matrix adjust. Identities = 24/101 (23%), Positives = 45/101 (44%), Gaps = 14/101 (13%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGN-------------SIKASSGING 83 V++IGSG++GL + +L S + + V LL+ +GG +G+ G Sbjct: 281 VIIIGSGVSGLAAARQLQS-FGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGG 339 Query: 84 AHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKE 124 M+ ++ K L+ A G+ VP D++ ++ Sbjct: 340 NPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQ 380 >5EZ7-A nrPDB Length = 392 Score = 28.9 bits (63), Expect = 5.5, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 29/47 (61%), Gaps = 1/47 (2%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGING 83 ++++G G+AGL + RL + VL++ A+ GG S+K+ I+G Sbjct: 10 ILIVGGGIAGLWLNARL-RRAGYATVLVESASLGGGQSVKSQGIIHG 55 >3KKJ-A nrPDB Length = 336 Score = 28.5 bits (62), Expect = 6.6, Method: Compositional matrix adjust. Identities = 15/41 (36%), Positives = 23/41 (56%), Gaps = 1/41 (2%) Query: 33 MKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGN 73 M P+ +IG+G+AGL+ + L + V L DK+ GG Sbjct: 1 MTVPIAIIGTGIAGLSAAQALTAAGHQ-VHLFDKSRGSGGR 40 >2AK2-A nrPDB Length = 233 Score = 28.5 bits (62), Expect = 7.2, Method: Compositional matrix adjust. Identities = 20/72 (27%), Positives = 34/72 (47%), Gaps = 6/72 (8%) Query: 303 LRGLGGILLHPTTGRRFTNELST-----RDTVTMEIQSKCPKNDNRALLVMSDKVYENYT 357 +R + G L+HP +GR + E + +D +T E + +DN+ L + + Y T Sbjct: 137 IRRITGRLIHPQSGRSYHEEFNPPKEPMKDDITGEPLIRR-SDDNKKALKIRLEAYHTQT 195 Query: 358 NNINFYMSKNLI 369 + Y SK I Sbjct: 196 TPLVEYYSKRGI 207 >4FX9-A nrPDB Length = 453 Score = 28.1 bits (61), Expect = 8.3, Method: Compositional matrix adjust. Identities = 14/46 (30%), Positives = 26/46 (56%), Gaps = 7/46 (15%) Query: 186 VQIMLNSEVVDIELDNQGHVTGVVYMDENGNRKIMKSHHVVFCSGG 231 + + LN+EV++++ TG V + ENG K + ++VF +G Sbjct: 77 IDLHLNAEVIEVD-------TGYVRVRENGGEKSYEWDYLVFANGA 115 >2C9Y-A nrPDB Length = 242 Score = 28.1 bits (61), Expect = 8.4, Method: Compositional matrix adjust. Identities = 22/107 (20%), Positives = 44/107 (41%), Gaps = 13/107 (12%) Query: 303 LRGLGGILLHPTTGRRFTNELST-----RDTVTMEIQSKCPKNDNRALLVMSDKVYENYT 357 +R + G L+HP +GR + E + +D +T E + ++ +AL + + T Sbjct: 137 IRRITGRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNEKALKIRLQAYHTQTT 196 Query: 358 NNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKD 404 I +Y + + + + QT + L ++S KD Sbjct: 197 PLIEYYRKRGIHSAIDAS--------QTPDVVFASILAAFSKATCKD 235 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5ZYN-B nrPDB 578 e-165 1QO8-A nrPDB 465 e-131 1KSU-A nrPDB 438 e-123 1D4E-A nrPDB 433 e-122 5KXJ-A nrPDB 397 e-111 1KNR-A nrPDB 385 e-107 2E5V-A nrPDB 297 6e-81 2B76-A nrPDB 292 2e-79 2WDR-A nrPDB 279 2e-75 2H88-A nrPDB 278 3e-75 4YTP-A nrPDB 273 1e-73 3VR8-A nrPDB 265 3e-71 5XMJ-A nrPDB 245 2e-65 2BS2-A nrPDB 244 6e-65 Sequences not found previously or not previously below threshold: 4C3X-A nrPDB 78 1e-14 3GYX-A nrPDB 43 5e-04 5L46-A nrPDB 42 5e-04 5EQD-A nrPDB 41 8e-04 5BR7-A nrPDB 41 0.001 4P9S-A nrPDB 41 0.002 1PJ5-A nrPDB 40 0.002 4RPJ-A nrPDB 40 0.002 2GAG-B nrPDB 38 0.007 5EZ7-A nrPDB 38 0.008 4IA5-A nrPDB 38 0.009 3MJ4-A nrPDB 38 0.014 1SEZ-A nrPDB 37 0.015 4JNQ-A nrPDB 37 0.018 3IHG-A nrPDB 37 0.019 1F8S-A nrPDB 37 0.023 4ZCC-A nrPDB 36 0.033 3OC4-A nrPDB 36 0.033 5MOG-A nrPDB 36 0.043 3L1R-A nrPDB 36 0.046 3KVE-A nrPDB 36 0.050 1GPE-A nrPDB 36 0.052 3KKJ-A nrPDB 35 0.056 1RP0-A nrPDB 35 0.065 5EVY-X nrPDB 35 0.072 4X4J-A nrPDB 35 0.077 2JB2-A nrPDB 35 0.086 5L3D-A nrPDB 35 0.093 3ABT-A nrPDB 35 0.093 1O5W-A nrPDB 34 0.14 2BXR-A nrPDB 34 0.14 2GMH-A nrPDB 34 0.19 1REO-A nrPDB 33 0.24 3FPZ-A nrPDB 33 0.34 4ILK-A nrPDB 33 0.35 5MJK-A nrPDB 33 0.41 3CGD-A nrPDB 33 0.45 2AAQ-A nrPDB 33 0.45 3JBO-G nrPDB 32 0.47 3J7A-G nrPDB 32 0.47 3RHA-A nrPDB 32 0.51 4UIR-A nrPDB 32 0.53 2YVG-A nrPDB 32 0.63 3ATQ-A nrPDB 32 0.68 4YNU-A nrPDB 31 0.83 4RG3-A nrPDB 31 0.84 4C5O-A nrPDB 31 0.84 3BI4-A nrPDB 31 0.87 2GV8-A nrPDB 31 0.89 5X1Y-B nrPDB 31 0.92 5Y77-A nrPDB 31 0.95 4V6B-AA nrPDB 31 1.1 3F8P-A nrPDB 31 1.1 3R9U-A nrPDB 31 1.2 1I8T-A nrPDB 31 1.5 1FOH-A nrPDB 31 1.5 1PS9-A nrPDB 31 1.6 4IV9-A nrPDB 31 1.8 6N7F-A nrPDB 30 1.8 2BKW-A nrPDB 30 1.8 4PLW-A nrPDB 30 1.9 1GAL-A nrPDB 30 2.1 3NIX-A nrPDB 30 2.2 4CBQ-A nrPDB 30 2.3 5TR3-A nrPDB 30 2.5 3TL2-A nrPDB 30 2.5 5XYI-C nrPDB 30 2.8 3IHM-A nrPDB 30 2.9 1C0L-A nrPDB 30 3.0 4UDQ-A nrPDB 30 3.1 4H7U-A nrPDB 30 3.1 3IC9-A nrPDB 30 3.2 4NTC-A nrPDB 30 3.2 5CEE-A nrPDB 30 3.3 4YRY-B nrPDB 30 3.3 3UKH-A nrPDB 30 3.3 5Z70-A nrPDB 30 3.4 3ISH-A nrPDB 30 3.6 2DZD-A nrPDB 30 3.8 4Z25-A nrPDB 29 4.0 5NCC-A nrPDB 29 4.1 4JDR-A nrPDB 29 4.2 2TMD-A nrPDB 29 4.3 3FLC-O nrPDB 29 4.4 5J7X-A nrPDB 29 4.5 1GEU-A nrPDB 29 4.6 5XXU-C nrPDB 29 4.8 3LAD-A nrPDB 29 4.8 2YQU-A nrPDB 29 5.0 2Q7V-A nrPDB 29 5.0 4OVI-A nrPDB 29 5.1 5TUF-A nrPDB 29 5.3 1F6M-A nrPDB 29 5.3 5J7I-A nrPDB 29 5.3 1DOD-A nrPDB 29 5.5 3K30-A nrPDB 29 5.9 3JSK-A nrPDB 29 6.3 5VDN-A nrPDB 29 6.5 6ER9-A nrPDB 28 7.2 2VHY-A nrPDB 28 7.9 6BWT-A nrPDB 28 8.1 4GCM-A nrPDB 28 8.3 2CVJ-A nrPDB 28 8.5 1VRQ-A nrPDB 28 8.6 4Y4N-A nrPDB 28 9.4 5U8W-A nrPDB 28 9.6 4AP1-A nrPDB 28 9.9 >5ZYN-B nrPDB Length = 471 Score = 578 bits (1488), Expect = e-165, Method: Composition-based stats. Identities = 470/470 (100%), Positives = 470/470 (100%) Query: 32 SMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQN 91 SMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQN Sbjct: 2 SMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQN 61 Query: 92 LKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHSV 151 LKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHSV Sbjct: 62 LKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHSV 121 Query: 152 PRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYM 211 PRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYM Sbjct: 122 PRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYM 181 Query: 212 DENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAE 271 DENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAE Sbjct: 182 DENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAE 241 Query: 272 LIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTM 331 LIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTM Sbjct: 242 LIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTM 301 Query: 332 EIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELV 391 EIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELV Sbjct: 302 EIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELV 361 Query: 392 TELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIK 451 TELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIK Sbjct: 362 TELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIK 421 Query: 452 KNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIAKLY 501 KNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIAKLY Sbjct: 422 KNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIAKLY 471 >1QO8-A nrPDB Length = 566 Score = 465 bits (1196), Expect = e-131, Method: Composition-based stats. Identities = 150/481 (31%), Positives = 245/481 (50%), Gaps = 30/481 (6%) Query: 20 VLKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASS 79 + K +G +T+ V+V+G+G AG S K V+L+DKA GGNS+ ++ Sbjct: 110 IQKAIAAGPSETTQ---VLVVGAGSAGFNASL-AAKKAGANVILVDKAPFSGGNSMISAG 165 Query: 80 GINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLK 139 G+N T Q V D E F++D + + + L+ L ++S ++WL++ Sbjct: 166 GMNAVGTKQQTAHGVEDKVEWFIEDAMKGGRQQNDIKLVTILAEQSADGVQWLES-LGAN 224 Query: 140 LDLLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIEL 199 LD L + GG V RTHR G G EI+ L K K+ + LNS VV + + Sbjct: 225 LDDLKRSGGARVDRTHRPHGGKSSGPEIIDTLRKAAKEQG------IDTRLNSRVVKLVV 278 Query: 200 DNQGHVTGVVYMDENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTG 259 ++ V G V ++ ++ + VV +GG+G +KEM+ Y P + + ++N TG Sbjct: 279 NDDHSVVGAVVHGKHTGYYMIGAKSVVLATGGYGMNKEMIAYYRPTMKDMTSSNNITATG 338 Query: 260 DGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRF 319 DG + ++GA + D+D VQ HPT D + L +E +RG+G ++++ G RF Sbjct: 339 DGVLMAKEIGASMTDIDWVQAHPTVGKDS-------RILISETVRGVGAVMVN-KDGNRF 390 Query: 320 TNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIR 379 +EL+TRD + I + A ++ +++Y+ + + L K ++ L + Sbjct: 391 ISELTTRDKASDAILKQP---GQFAWIIFDNQLYKKAKMVRGYDHLEMLYKGDTVEQLAK 447 Query: 380 QYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDIS-TESTVYVGEVTPVVHFTM 438 +T ++ K+ SD N + D ++ T+S Y +V P +H TM Sbjct: 448 -----STGMKVADLAKTVSDYNGYVASGKDTAFGRADMPLNMTQSPYYAVKVAPGIHHTM 502 Query: 439 GGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIA 498 GGV IN + V+ S+ +G+FAAGEV+GGVHG NRLGG+++ + VVFG+ A DN A Sbjct: 503 GGVAINTTASVLDLQSKP--IDGLFAAGEVTGGVHGYNRLGGNAIADTVVFGRIAGDNAA 560 Query: 499 K 499 K Sbjct: 561 K 561 >1KSU-A nrPDB Length = 571 Score = 438 bits (1127), Expect = e-123, Method: Composition-based stats. Identities = 148/484 (30%), Positives = 248/484 (51%), Gaps = 36/484 (7%) Query: 21 LKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSG 80 S T V SG AG + + V+L++K IGGN+ A+ G Sbjct: 116 QAALASAPHDTVDVVVVG---SGGAGFSAAISATD-SGAKVILIEKEPVIGGNAKLAAGG 171 Query: 81 INGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKL 140 +N A TD Q+ K+ D+PEL +DT+ + P+L+ L+ SK ++ W+ T L Sbjct: 172 MNAAWTDQQKAKKITDSPELMFEDTMKGGQNINDPALVKVLSSHSKDSVDWM-TAMGADL 230 Query: 141 DLLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELD 200 + +GG SV R HR +G G +VQ L D + K + + + +N+ +++ D Sbjct: 231 TDVGMMGGASVNRAHRPTGGAGVGAHVVQVLY----DNAVKRN--IDLRMNTRGIEVLKD 284 Query: 201 NQGHVTGVVYMDENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGD 260 ++G V G++ +K+ V+ +GGF + E + + P+L +TN GD Sbjct: 285 DKGTVKGILVKGMYKGYYWVKADAVILATGGFAKNNERVAKLDPSLKGFISTNQPGAVGD 344 Query: 261 GQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFT 320 G + G L DM +Q HPT + + EA+RG G IL++ G+RF Sbjct: 345 GLDVAENAGGALKDMQYIQAHPTLSVKGG-------VMVTEAVRGNGAILVN-REGKRFV 396 Query: 321 NELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQ 380 NE++TRD + I ++ K+ A L+ D V ++ + I+ Y+ + + + L++ Sbjct: 397 NEITTRDKASAAILAQTGKS---AYLIFDDSVRKSLSK-IDKYIGLGVAP--TADSLVKL 450 Query: 381 YDLQTTASELVTE-LKSYSDV--NTKDT-FDRPLIINAFDKDISTESTVYVGEVTPVVHF 436 ++ + +TE + Y+ + + KDT F+RP + A + E Y EVTP VH+ Sbjct: 451 GKMEGIDGKALTETVARYNSLVSSGKDTDFERPNLPRALN-----EGNYYAIEVTPGVHY 505 Query: 437 TMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADN 496 TMGGV I+ K++V+ N++ + G++ AGEV+GGVHGANRLGG+++ + + FG+ A + Sbjct: 506 TMGGVMIDTKAEVM--NAKKQVIPGLYGAGEVTGGVHGANRLGGNAISDIITFGRLAGEE 563 Query: 497 IAKL 500 AK Sbjct: 564 AAKY 567 >1D4E-A nrPDB Length = 572 Score = 433 bits (1113), Expect = e-122, Method: Composition-based stats. Identities = 147/482 (30%), Positives = 230/482 (47%), Gaps = 33/482 (6%) Query: 22 KRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGI 81 K +G +T+ VVI + V+LL+K GGN+ A+ G+ Sbjct: 117 KAIAAGVKETTD----VVIIGSGGAGLAAAVSARDAGAKVILLEKEPIPGGNTKLAAGGM 172 Query: 82 NGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLD 141 N A T Q L + D ++ + DT+ + P L+ L S +I WL T + Sbjct: 173 NAAETKPQAKLGIEDKKQIMIDDTMKGGRNINDPELVKVLANNSSDSIDWL-TSMGADMT 231 Query: 142 LLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDN 201 + ++GG SV R+HR +G G + Q L D + K I LNS VV I D Sbjct: 232 DVGRMGGASVNRSHRPTGGAGVGAHVAQVLW----DNAVKRG--TDIRLNSRVVRILEDA 285 Query: 202 QGHVTGVVYMDENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDG 261 G VTGV+ E ++K+ VV +GGF + E + +Y P L TN TGDG Sbjct: 286 SGKVTGVLVKGEYTGYYVIKADAVVIAAGGFAKNNERVSKYDPKLKGFKATNHPGATGDG 345 Query: 262 QKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTN 321 + + GA D+ +Q HPT + EA+RG G I+++ G RF N Sbjct: 346 LDVALQAGAATRDLQYIQAHPT-------YSPAGGVMITEAVRGNGAIVVN-REGNRFMN 397 Query: 322 ELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQY 381 E++TRD + I + A LV D + ++ + + + +I +L +Q Sbjct: 398 EITTRDKASAAILQ---QKGESAYLVFDDSIRKSLKAIEGYVHLNIVKEGKTIEELAKQI 454 Query: 382 DLQTTASELVTELKSYSDV--NTKDT-FDRPLIINAFDKDISTESTVYVGEVTPVVHFTM 438 D+ A+EL + +Y+ + KD F+RP + + Y E+ P VH TM Sbjct: 455 DV--PAAELAKTVTAYNGFVKSGKDAQFERPDLPRELVV-----APFYALEIAPAVHHTM 507 Query: 439 GGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIA 498 GG+ I+ K++V + + ++ G++AAGEV+GGVHGANRLGG+++ + V +G+ A + A Sbjct: 508 GGLVIDTKAEVKSEKTAKPIT-GLYAAGEVTGGVHGANRLGGNAISDIVTYGRIAGASAA 566 Query: 499 KL 500 K Sbjct: 567 KF 568 >5KXJ-A nrPDB Length = 557 Score = 397 bits (1019), Expect = e-111, Method: Composition-based stats. Identities = 119/483 (24%), Positives = 202/483 (41%), Gaps = 105/483 (21%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMD 96 V++IGSG AGL+ + RL K++ V++L K G++ A GI +T D Sbjct: 11 VLIIGSGAAGLSLALRLAEKHK--VIVLSKGPVSEGSTFYAQGGIAAVFDET-------D 61 Query: 97 TPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTE---FDLKLDL-------LAQL 146 + ++DTL + G ++ + +++ ++WL + FD + L + Sbjct: 62 SIASHVEDTLIAGAGICDRHAVEFVASNARTCVQWLIDQGVLFDTHVQPNGKESYHLTRE 121 Query: 147 GGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVT 206 GGHS R ++ G E+ L + ++ + +Q++ S VD+ + ++ + Sbjct: 122 GGHSHRRILHAADAT--GKEVETTLVSRAQNHPN-----IQVLERSNAVDLIISDKMGLP 174 Query: 207 G----VVYMDENGNRKIMKSHH---VVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTG 259 G V N N++ +++ H VV +GG ++ TTN ++G Sbjct: 175 GPRRVVGAWIWNRNKEWVETCHAKSVVLATGGASK------------VYQYTTNPDISSG 222 Query: 260 DGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRF 319 DG + + G + +++ Q HPT P R FL EALRG G L P G RF Sbjct: 223 DGIAMAWRAGCRVANLEFNQFHPTALYHPQAR----NFLLTEALRGEGAYLKRP-DGSRF 277 Query: 320 TNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSI--NDL 377 P D R L D V + + + + +S +D Sbjct: 278 M-----------------PDVDERGELAPRDIVARAIDHEMKQLGADCMFLDISHKPDDF 320 Query: 378 IRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFT 437 +RQ+ A L D+ + T V P H+T Sbjct: 321 VRQHFPMIYAKLL---------------------------DLGMDLTKEPIPVVPAAHYT 353 Query: 438 MGGVKINEKSQVIKKNSESVLSNGIFAAGEVS-GGVHGANRLGGSSLLECVVFGKTAADN 496 GGV +++ + +G++A GEVS G+HGANR+ +SLLEC+V+G +AA + Sbjct: 354 CGGVVVDDYGRTD--------VDGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAMD 405 Query: 497 IAK 499 I + Sbjct: 406 IDR 408 >1KNR-A nrPDB Length = 540 Score = 385 bits (988), Expect = e-107, Method: Composition-based stats. Identities = 116/481 (24%), Positives = 193/481 (40%), Gaps = 101/481 (20%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMD 96 V++IGSG AGL+ + RL +++ V++L K G++ A GI +T D Sbjct: 11 VLIIGSGAAGLSLALRLADQHQ--VIVLSKGPVTEGSTFYAQGGIAAVFDET-------D 61 Query: 97 TPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTE---FDLKLDL-------LAQL 146 + + ++DTL + G ++ + ++S ++WL + FD + L + Sbjct: 62 SIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTRE 121 Query: 147 GGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKD----SNLVQIMLNSEVVDIELDNQ 202 GGHS R ++ G E+ L K + + +N V ++++ + I L Sbjct: 122 GGHSHRRILHAADAT--GREVETTLVSKALNHPNIRVLERTNAVDLIVSDK---IGLPGT 176 Query: 203 GHVTGVVYMDENG-NRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDG 261 V G + N + + VV +GG ++ TTN ++GDG Sbjct: 177 RRVVGAWVWNRNKETVETCHAKAVVLATGGASK------------VYQYTTNPDISSGDG 224 Query: 262 QKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTN 321 + + G + +++ Q HPT P R FL EALRG G L P G RF Sbjct: 225 IAMAWRAGCRVANLEFNQFHPTALYHPQAR----NFLLTEALRGEGAYLKRP-DGTRFM- 278 Query: 322 ELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSIN--DLIR 379 P D R L D V + + + + +S D IR Sbjct: 279 ----------------PDFDERGELAPRDIVARAIDHEMKRLGADCMFLDISHKPADFIR 322 Query: 380 QYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMG 439 Q+ L D++ E + P H+T G Sbjct: 323 QHFPMIYEKLL-----------------------GLGIDLTQEP----VPIVPAAHYTCG 355 Query: 440 GVKINEKSQVIKKNSESVLSNGIFAAGEVS-GGVHGANRLGGSSLLECVVFGKTAADNIA 498 GV +++ + G++A GEVS G+HGAN + +SLLEC+V+G +AA++I Sbjct: 356 GVMVDDHGRTD--------VEGLYAIGEVSYTGLHGANLMASNSLLECLVYGWSAAEDIT 407 Query: 499 K 499 + Sbjct: 408 R 408 >2E5V-A nrPDB Length = 472 Score = 297 bits (761), Expect = 6e-81, Method: Composition-based stats. Identities = 113/460 (24%), Positives = 178/460 (38%), Gaps = 106/460 (23%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMD 96 + +IGSG+AGL+ L + V L+ K GG++ A G+ ++ D Sbjct: 2 IYIIGSGIAGLSAGVAL-RRAGKKVTLISKRID-GGSTPIAKGGVAA-------SVGSDD 52 Query: 97 TPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTE-FDLKLDLLAQLGGHSVPRTH 155 +PEL +DT+ G ++ +T E+K+ I ++ F+ + DL GGH+ R Sbjct: 53 SPELHAQDTIRVGDGLCDVKTVNYVTSEAKNVIETFESWGFEFEEDLRL-EGGHTKRRVL 111 Query: 156 RSSGKLPPGFEIVQALSKKLKD--ISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMDE 213 + G EI L K ++ I + LV+I + G VTG V Sbjct: 112 HRTD--ETGREIFNFLLKLAREEGIPIIEDRLVEIRVK----------DGKVTGFVTEKR 159 Query: 214 NGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELI 273 + K +V +GG+ Y ++ ++ GDG I K G L Sbjct: 160 GLVEDVDK---LVLATGGYSY------------LYEYSSTQSTNIGDGMAIAFKAGTILA 204 Query: 274 DMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTMEI 333 DM+ VQ HPT + FL E LRG G +++ G RF R Sbjct: 205 DMEFVQFHPTVTSLDGE-----VFLLTETLRGEGAQIINE-NGERFLFNYDKR------- 251 Query: 334 QSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTE 393 L D + E++ Sbjct: 252 ----------GELAPRDILSRAIY------------------------------IEMLKG 271 Query: 394 LKSYSDVNTKDTFDRPLIINAFDKDISTESTVY--VGEVTPVVHFTMGGVKINEKSQVIK 451 K + D++ + F+R + A K ++ Y + P HF GG+++N + + Sbjct: 272 HKVFIDLSKIEDFERKFPVVA--KYLARHGHNYKVKIPIFPAAHFVDGGIRVNIRGESNI 329 Query: 452 KNSESVLSNGIFAAGEVS-GGVHGANRLGGSSLLECVVFG 490 N ++A GEVS G+HGANRL +SLLE +VFG Sbjct: 330 VN--------LYAIGEVSDSGLHGANRLASNSLLEGLVFG 361 >2B76-A nrPDB Length = 602 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 109/452 (24%), Positives = 172/452 (38%), Gaps = 82/452 (18%) Query: 60 PVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMD 119 + L+ K + +++ A G D D+ E DT+ ++D Sbjct: 32 KIALISKVYPMRSHTVAAQGGSAAVAQD-------HDSFEYHFHDTVAGGDWLCEQDVVD 84 Query: 120 KLTKESKSAIRWLQTEF-------DLKLDLLAQLGGHSVPRTHRSSGKLPPGFEIVQAL- 171 + + L+ D ++ + + GG + RT ++ K GF ++ L Sbjct: 85 YFVHHCPTEMTQLELWGCPWSRRPDGSVN-VRRFGGMKIERTWFAADKT--GFHMLHTLF 141 Query: 172 --SKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMD-ENGNRKIMKSHHVVFC 228 S + I D + V +DI +D+ GHV G+V M+ G ++++ VV Sbjct: 142 QTSLQFPQIQRFDEHFV--------LDILVDD-GHVRGLVAMNMMEGTLVQIRANAVVMA 192 Query: 229 SGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQVHPTGFIDP 288 +GG G ++ TNG TGDG + G L DM+ VQ HPTG Sbjct: 193 TGGAGR------------VYRYNTNGGIVTGDGMGMALSHGVPLRDMEFVQYHPTGLPGS 240 Query: 289 NDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVM 348 L E RG GGIL++ G R+ + + E PKN L Sbjct: 241 G-------ILMTEGCRGEGGILVN-KNGYRYLQDYG----MGPETPLGEPKNKYM-ELGP 287 Query: 349 SDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDR 408 DKV + + + K D++ +L L Sbjct: 288 RDKVSQAFWHE----WRKGNTISTPRGDVVYLDLRHLGEKKLHERL-------------- 329 Query: 409 PLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEV 468 P I + + V P H+TMGG++ ++ + G+FA GE Sbjct: 330 PFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETDQNCETR--------IKGLFAVGEC 381 Query: 469 SG-GVHGANRLGGSSLLECVVFGKTAADNIAK 499 S G+HGANRLG +SL E VVFG+ A + + Sbjct: 382 SSVGLHGANRLGSNSLAELVVFGRLAGEQATE 413 >2WDR-A nrPDB Length = 588 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 107/468 (22%), Positives = 171/468 (36%), Gaps = 94/468 (20%) Query: 54 ISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRG 113 IS+ LL K +++ A GI A +T D E + DT+ + G Sbjct: 26 ISQSGQTCALLSKVFPTRSHTVSAQGGITVALGNTH-----EDNWEWHMYDTVKGSDYIG 80 Query: 114 VPSLMDKLTKESKSAIRWLQ------TEFDLKLDLLAQLGGHSVP-----RTHRSSGKLP 162 ++ + K AI L+ + D GG S ++ Sbjct: 81 DQDAIEYMCKTGPEAILELEHMGLPFSRLDDGRIYQRPFGGQSKNFGGEQAARTAAAADR 140 Query: 163 PGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMD-ENGNRKIMK 221 G ++ L ++ N I +D+ + G V G + E G K Sbjct: 141 TGHALLHTLYQQ------NLKNHTTIFSEWYALDLVKNQDGAVVGCTALCIETGEVVYFK 194 Query: 222 SHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQVH 281 + V +GG G I+ TTN TGDG + + G + DM+ Q H Sbjct: 195 ARATVLATGGAGR------------IYQSTTNAHINTGDGVGMAIRAGVPVQDMEMWQFH 242 Query: 282 PTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFT-------NELSTRDTVTMEIQ 334 PTG L E RG GG LL+ G RF +L+ RD V I Sbjct: 243 PTGIAGAG-------VLVTEGCRGEGGYLLN-KHGERFMERYAPNAKDLAGRDVVARSIM 294 Query: 335 SKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTEL 394 + + D + + K+ ++ L ++ L++ ++ Sbjct: 295 IEIREGRG------CDGPWGPHA-------------KLKLDHLGKEV-LESRLPGILELS 334 Query: 395 KSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKKN- 453 ++++ V + V P H+ MGG+ Q + N Sbjct: 335 RTFAHV---------------------DPVKEPIPVIPTCHYMMGGIPTKVTGQALTVNE 373 Query: 454 -SESVLSNGIFAAGEVSG-GVHGANRLGGSSLLECVVFGKTAADNIAK 499 E V+ G+FA GE++ VHGANRLGG+SLL+ VVFG+ A ++ + Sbjct: 374 KGEDVVVPGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGLHLQE 421 >2H88-A nrPDB Length = 621 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 109/467 (23%), Positives = 181/467 (38%), Gaps = 96/467 (20%) Query: 55 SKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGV 114 S+ + K +++ A GIN A + + D DT+ + G Sbjct: 38 SEAGFNTACVTKLFPTRSHTVAAQGGINAALGNME-----DDNWRWHFYDTVKGSDWLGD 92 Query: 115 PSLMDKLTKESKSAIRWLQTE-FDLKLDLLAQ-----LGGHSVP-----RTHRSSGKLP- 162 + +T+++ +A+ L+ + GG S+ + HR Sbjct: 93 QDAIHYMTEQAPAAVIELENYGMPFSRTEEGKIYQRAFGGQSLQFGKGGQAHRCCCVADR 152 Query: 163 PGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMD-ENGNRKIMK 221 G ++ L + +D+ ++N G GV+ + E+G + Sbjct: 153 TGHSLLHTLY------GRSLRYDTSYFVEYFALDLLMEN-GECRGVIALCIEDGTIHRFR 205 Query: 222 SHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQVH 281 + + V +GG+G + + T+ +TGDG ++++ G D++ VQ H Sbjct: 206 AKNTVIATGGYGRT------------YFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFH 253 Query: 282 PTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFT-------NELSTRDTVTMEIQ 334 PTG L E RG GGIL++ + G RF +L++RD V+ + Sbjct: 254 PTGIYGAG-------CLITEGCRGEGGILIN-SQGERFMERYAPVAKDLASRDVVSRSMT 305 Query: 335 SKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTEL 394 + + R D VY + ++ L Q +L T L Sbjct: 306 IEIR--EGRGCGPEKDHVY------------------LQLHHLPPQ--------QLATRL 337 Query: 395 KSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKK-N 453 S+ + D++ E V P VH+ MGG+ N K QVI N Sbjct: 338 PGISETA----------MIFAGVDVTKEP----IPVLPTVHYNMGGIPTNYKGQVITHVN 383 Query: 454 SESVLSNGIFAAGE-VSGGVHGANRLGGSSLLECVVFGKTAADNIAK 499 E + G++A GE S VHGANRLG +SLL+ VVFG+ A IA+ Sbjct: 384 GEDKVVPGLYACGEAASASVHGANRLGANSLLDLVVFGRACALTIAE 430 >4YTP-A nrPDB Length = 664 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 101/467 (21%), Positives = 178/467 (38%), Gaps = 96/467 (20%) Query: 55 SKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGV 114 S+ + K +++ A GIN A + + D DT+ + G Sbjct: 81 SEAGFNTACVTKLFPTRSHTVAAQGGINAALGNME-----EDNWRWHFYDTVKGSDWLGD 135 Query: 115 PSLMDKLTKESKSAIRWLQTE-FDLKLDLLAQ-----LGGHSVP-----RTHRSSGKLP- 162 + +T+++ +++ L+ + GG S+ + HR Sbjct: 136 QDAIHYMTEQAPASVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADR 195 Query: 163 PGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMD-ENGNRKIMK 221 G ++ L + +D+ ++N G GV+ + E+G+ ++ Sbjct: 196 TGHSLLHTLY------GRSLRYDTSYFVEYFALDLLMEN-GECRGVIALCIEDGSIHRIR 248 Query: 222 SHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQVH 281 + + V +GG+G + + T+ +TGDG ++++ G D++ VQ H Sbjct: 249 ARNTVVATGGYGRT------------YFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFH 296 Query: 282 PTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFT-------NELSTRDTVTMEIQ 334 PTG L E RG GGIL++ + G RF +L++RD V+ + Sbjct: 297 PTGIYGAG-------CLITEGCRGEGGILIN-SQGERFMERYAPVAKDLASRDVVSRSMT 348 Query: 335 SKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTEL 394 + + R D VY + ++ L + Sbjct: 349 LEIR--EGRGCGPEKDHVY------------------LQLHHLPPEQL------------ 376 Query: 395 KSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKK-N 453 P I + T V P VH+ MGG+ N K QV++ N Sbjct: 377 ----------AVRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLRHVN 426 Query: 454 SESVLSNGIFAAGEVSG-GVHGANRLGGSSLLECVVFGKTAADNIAK 499 + + G++A GE + VHGANRLG +SLL+ VVFG+ A +IA+ Sbjct: 427 GQDQVVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAE 473 >3VR8-A nrPDB Length = 645 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 103/469 (21%), Positives = 171/469 (36%), Gaps = 101/469 (21%) Query: 56 KYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVP 115 + ++ K ++ A GIN A D + DT + G Sbjct: 62 EAGFKTAVVTKMFPTRSHTTAAQGGINAALGSMNP-----DDWKWHFYDTAKGSDWLGDQ 116 Query: 116 SLMDKLTKESKSAIRWLQT-EFDLKLDLLAQ-----LGGHSVP--------RTHRSSGKL 161 + M LT+ + A+ L+ + GG S RT + + Sbjct: 117 NAMHYLTRNAVEAVTELENFGMPFSRTPEGKIYQRSFGGQSNNYGKGGVAKRTCCVADRT 176 Query: 162 PPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMD-ENGNRKIM 220 G ++ L + + +D+ + ++G GV+ + E+G Sbjct: 177 --GHSMLHTLY------GNSLRCHCTFFIEYFALDLLM-DKGRCVGVIALCLEDGTIHRF 227 Query: 221 KSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQV 280 +S + +GG+G + + T TGDG + ++ G L D++ +Q Sbjct: 228 RSKRTIVATGGYGRA------------YFSCTTAHMNTGDGTALATRAGIALEDLEFIQF 275 Query: 281 HPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFT-------NELSTRDTVTMEI 333 HPTG L E RG GG L++ + G RF +L++RD V+ Sbjct: 276 HPTGIYGVG-------CLITEGSRGEGGFLVN-SEGERFMERYAPKAKDLASRDVVSRAE 327 Query: 334 QSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTE 393 + + R + D +Y + ++ L A +L Sbjct: 328 TIEI--MEGRGVGPEKDHIY------------------LQLHHL--------PAEQLHQR 359 Query: 394 LKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKKN 453 L S+ + T V P VH+ MGG+ N K+QVIK Sbjct: 360 LPGISET--------------AKIFAGVDVTKEPIPVIPTVHYNMGGIPTNYKAQVIKYT 405 Query: 454 SE--SVLSNGIFAAGEVSG-GVHGANRLGGSSLLECVVFGKTAADNIAK 499 E + G++A GE + VHGANRLG +SLL+ VVFG+ + NI + Sbjct: 406 KEGGDKIVPGLYACGECACHSVHGANRLGANSLLDAVVFGRACSINIKE 454 >5XMJ-A nrPDB Length = 627 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 98/494 (19%), Positives = 164/494 (33%), Gaps = 103/494 (20%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMD 96 V+ IG LAG + S + ++L +S A G+ A + + D Sbjct: 8 VLCIGGALAGERVAVE-ASMAGLKTIMLSLVPPRRSHSSAAQGGMQAALGN--AIMGDGD 64 Query: 97 TPELFLKDTLHSAKGRGVPSLMDKLTKES----KSAIRWLQTE----------------F 136 +P++ DT+ + + + + W F Sbjct: 65 SPDVHFADTVKGSDWGCDQEVARIFADTAPIVMREVAHWGVPWNRVVPGKHTYYKGGKPF 124 Query: 137 DLKLDLLAQ-------LGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIM 189 + + GG + RT ++ G ++ L K + +Q Sbjct: 125 EAEEKAEKAGLIHARAFGGTAAWRTCYTADGT--GRSVLNTLDTKCLQYGVTVHDRMQ-- 180 Query: 190 LNSEVVDIELDNQGHVTGVVYMD-ENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIH 248 + + + G+ G + G + + +GG+G I+ Sbjct: 181 -----AEALIHDGGNCLGCIARCLRTGELVAYLATSTLIATGGYGR------------IY 223 Query: 249 LPTTNGKQTTGDGQKILSKLG-AELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLG 307 TTN G GQ I G + +M+ VQ HPTG + L E RG G Sbjct: 224 KATTNAVICDGGGQIIALDTGLVPMGNMEAVQFHPTGTVP-------TDILVTEGCRGDG 276 Query: 308 GILLHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKN 367 G LL RF + ++A L D V T +M K Sbjct: 277 GTLLD-VNQYRFMPDYEP----------------DKAQLASRDVVSRRMTE----HMRKG 315 Query: 368 LIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYV 427 L K D + + T+L+ D+ T + + Sbjct: 316 LGVKSPYGDHLWLDIRHLGEKHITTKLREVYDICT--------------NFLGVNPIHQL 361 Query: 428 GEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGG-VHGANRLGGSSLLEC 486 V P H++MGGV+ N ++ + G+F+AGE + +HG NRLGG+SL E Sbjct: 362 IPVRPTHHYSMGGVRTN-------RDGAAYGLKGLFSAGESACWDMHGFNRLGGNSLAET 414 Query: 487 VVFGKTAADNIAKL 500 VV G+ + + + Sbjct: 415 VVAGRYIGERMVEF 428 >2BS2-A nrPDB Length = 660 Score = 244 bits (623), Expect = 6e-65, Method: Composition-based stats. Identities = 96/499 (19%), Positives = 173/499 (34%), Gaps = 118/499 (23%) Query: 38 VVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDT 97 +VIG GLAGL + K + ++L +S A G+ + +++ + D Sbjct: 9 LVIGGGLAGLRAAVATQQK-GLSTIVLSLIPVKRSHSAAAQGGMQASLGNSKMSDG--DN 65 Query: 98 PELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTE---------------FDLKLDL 142 +L DT+ + + + AIR L + + Sbjct: 66 EDLHFMDTVKGSDWGCDQKVARMFVNTAPKAIRELAAWGVPWTRIHKGDRMAIINAQKTT 125 Query: 143 LAQ------------LGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIML 190 + + GG RT ++ + + + K +Q Sbjct: 126 ITEEDFRHGLIHSRDFGGTKKWRTCYTADATG------HTMLFAVANECLKLGVSIQDRK 179 Query: 191 NSEVVDIELDNQGHVTGVVYMDE-NGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHL 249 + + G G V D G+ + + +GG+G I+ Sbjct: 180 EAIA---LIHQDGKCYGAVVRDLVTGDIIAYVAKGTLIATGGYGR------------IYK 224 Query: 250 PTTNGKQTTGDGQKILSKLG-AELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGG 308 TTN G G I + G A+L +M+ VQ HPT L E RG GG Sbjct: 225 NTTNAVVCEGTGTAIALETGIAQLGNMEAVQFHPTPLFPSG-------ILLTEGCRGDGG 277 Query: 309 ILLHPTTGRRFTNEL-------STRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNIN 361 IL G RF + ++RD V+ + K + Sbjct: 278 IL-RDVDGHRFMPDYEPEKKELASRDVVSRRMIEHIRKGKG-----------------VQ 319 Query: 362 FYMSKNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDIST 421 ++L +SI L R++ ++T ++ + ++ ++ + + Sbjct: 320 SPYGQHLWLDISI--LGRKH-IETNLRDVQEICEYFAGIDPAEKW--------------- 361 Query: 422 ESTVYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGG-VHGANRLGG 480 V P+ H++MGG++ + + + G+F+AGE + +HG NRLGG Sbjct: 362 ------APVLPMQHYSMGGIRTDYRGEAK--------LKGLFSAGEAACWDMHGFNRLGG 407 Query: 481 SSLLECVVFGKTAADNIAK 499 +S+ E VV G + A+ Sbjct: 408 NSVSEAVVAGMIVGEYFAE 426 >4C3X-A nrPDB Length = 530 Score = 77.7 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 85/520 (16%), Positives = 169/520 (32%), Gaps = 66/520 (12%) Query: 32 SMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQN 91 + + V+V+GSG LT + ++ + ++L+K GG S + + I T Q+ Sbjct: 25 TSECDVLVVGSGGGALTGAYTAAAQ-GLTTIVLEKTDRFGGTSAYSGASIWLPGTQVQER 83 Query: 92 LKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQT------EFDLKLDLLAQ 145 + D+ E + L + G D + + + + L+ EF D Sbjct: 84 AGLPDSTE-NARTYLRALLGDAESERQDAYVETAPAVVALLEQNPNIEFEFRAFPDYYKA 142 Query: 146 LGGHSVPRTHRSSGKLP------------------------PGFEIVQALSKKLKDISSK 181 G R+ P PG I + + Sbjct: 143 EGRMDTGRSINPLDLDPADIGDLAGKVRPELDQDRTGQDHAPGPMIGGRALIGRLLAAVQ 202 Query: 182 DSNLVQIMLNSEVVDIELDNQGHVTGVVYMDENGNRKIMKSHHVVFCSGGFGYSKEMLKE 241 + ++ S + + +++ G V G ++I + V+ +GG + EM ++ Sbjct: 203 STGKAELRTESVLTSLIVED-GRVVGAEVESGGETQRIKANRGVLMAAGGIEGNAEMREQ 261 Query: 242 YSPNLIHLPTTNGKQT-TGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAA 300 + + TGD +G +DQ P + + F+ Sbjct: 262 AGTPGKAIWSMGPFGANTGDAISAGIAVGGATALLDQAWFCP----GVEQPDGSAAFMV- 316 Query: 301 EALRGLGGILLHPTTGRRFTNELSTRDTVTMEIQSK-----------CPKNDNRALLV-- 347 +RG L+ + G R+ NE D + + + L Sbjct: 317 -GVRGG---LVVDSAGERYLNESLPYDQFGRAMDAHDDNGSAVPSFMIFDSREGGGLPAI 372 Query: 348 ------MSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVN 401 + + + + + L + A++L + + + + Sbjct: 373 CIPNTAPAKHLEAGTWVGADTLEELAAKTGLPADALRSTVEKFNDAAKLGVDEEFHRGED 432 Query: 402 TKDTFDRPLIINAFDKDISTE-STVYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSN 460 D F P A + E Y + T GG+ + +V++ + + + Sbjct: 433 PYDAFFCPPNGGANAALTAIENGPFYAARIVLSDLGTKGGLVTDVNGRVLRADGSA--ID 490 Query: 461 GIFAAGEVSGGVHGANRLG-GSSLLECVVFGKTAADNIAK 499 G++AAG S + G G G L +VF AA ++AK Sbjct: 491 GLYAAGNTSASLSGRFYPGPGVPLGTAMVFSYRAAQDMAK 530 >3GYX-A nrPDB Length = 662 Score = 42.6 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 70/510 (13%), Positives = 149/510 (29%), Gaps = 91/510 (17%) Query: 37 VVVIGSGLAGLTTS---NRLISKY--RIPVVLLDKAASIGGNSIKASSGINGAHTDTQQN 91 ++++G G+ + R KY ++L+DKA S+ + A G++ +T N Sbjct: 25 LLMVGGGMGNCGAAFEAVRWADKYAPEAKILLVDKA-SLERSGAVAQ-GLSAINTYLGDN 82 Query: 92 LKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIR---------WLQTEFDLKLD- 141 D + D + G L+ L + ++ W++ E LD Sbjct: 83 -NADDYVRMVRTDLM----GLVREDLIYDLGRHVDDSVHLFEEWGLPVWIKDEHGHNLDG 137 Query: 142 LLAQLGGHSVPRTHRSSGKLP----PGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDI 197 A+ G S+ + E + + + + +++ + + + Sbjct: 138 AQAKAAGKSLRNGDKPVRSGRWQIMINGESYKVIVAEAAKNALGQDRIIE-RIFIVKLLL 196 Query: 198 ELDNQGHVTGVVYMDENGN-RKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTN--- 253 + + + G V + N I K++ +V GG + Y P + Sbjct: 197 DKNTPNRIAGAVGFNLRANEVHIFKANAMVVACGGA------VNVYRPRSVGEGMGRAWY 250 Query: 254 GKQTTGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLA---AEALRGLGGIL 310 G + +++GAE+ M+ + P F D W L A +G Sbjct: 251 PVWNAGSTYTMCAQVGAEMTMME-NRFVPARFKDGYGPVGAWFLLFKAKATNCKGEDYCA 309 Query: 311 LHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIK 370 + R + C N+ + I Sbjct: 310 TNRA----MLKPYEERGYAKGHVIPTC---------------LRNHMMLREMREGRGPIY 350 Query: 371 KVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEV 430 + L + + A + E +++ D D + + E+ Sbjct: 351 MDTKTALQTSFATMSPAQQKHLEAEAWEDF-----LDMCVGQANLWAATNCAPEERGSEI 405 Query: 431 TPVVHFTMGG----------------VKINEKSQVIKKNSESVL--SNGIFAAGE-VSGG 471 P + +G V + K + + + G++ + V Sbjct: 406 MPTEPYLLGSHSGCCGIWASGPDEAWVPEDYKVRAANGKVYNRMTTVEGLWTCADGVGAS 465 Query: 472 VHGANRLGGSSLLECVVFGKTAADNIAKLY 501 H + S E G+ + + Y Sbjct: 466 GH---KFSSGSHAE----GRIVGKQMVRWY 488 >5L46-A nrPDB Length = 841 Score = 42.2 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 20/81 (24%), Positives = 33/81 (40%) Query: 21 LKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSG 80 K LS Q + V+IG G G++ + L VVLL+K+ G++ A+ Sbjct: 9 EKPPLSAETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGL 68 Query: 81 INGAHTDTQQNLKVMDTPELF 101 H D+ +L+ Sbjct: 69 TTYFHPGINLKKIHYDSIKLY 89 >5EQD-A nrPDB Length = 400 Score = 41.5 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 13/45 (28%), Positives = 26/45 (57%) Query: 31 TSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSI 75 ++ + V+GSG GLT + R ++ V+++++ IGGN+ Sbjct: 1 STGNFDLFVVGSGFFGLTIAERAATQLGKRVLVIERRPHIGGNAY 45 >5BR7-A nrPDB Length = 393 Score = 40.7 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 15/39 (38%), Positives = 27/39 (69%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSI 75 ++V+GSGL GLT + R S+ V++++K + +GGN+ Sbjct: 6 LIVVGSGLFGLTVAERAASQLGKKVLIVEKRSHLGGNAY 44 >4P9S-A nrPDB Length = 848 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 16/74 (21%), Positives = 30/74 (40%) Query: 28 TDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTD 87 + + V+IG G G++ + L VVLL+K+ G++ A+ H Sbjct: 17 PPEWKDRAETVIIGGGCVGVSLAYHLAKAGMRDVVLLEKSELTAGSTWHAAGLTTYFHPG 76 Query: 88 TQQNLKVMDTPELF 101 D+ +L+ Sbjct: 77 INLKKIHYDSIKLY 90 >1PJ5-A nrPDB Length = 830 Score = 40.3 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 43/213 (20%), Positives = 77/213 (36%), Gaps = 28/213 (13%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAAS--IGGNSIKASSGINGAHTDTQQNLKV 94 +V+IG+G+ G ++ L+++ + +LD+ GG++ A + + Sbjct: 7 IVIIGAGIVGTNLADELVTRGWNNITVLDQGPLNMPGGSTSHAPGLVFQTNPSKTMASFA 66 Query: 95 MDTPELFLKDTLHSAKGRGVPSLMDKLTKESK---------SAIRW-----LQTEFDLKL 140 T E L T ++ T E++ A W L + + + Sbjct: 67 KYTVEKLLSLTEDGVSCFNQVGGLEVATTETRLADLKRKLGYAAAWGIEGRLLSPAECQE 126 Query: 141 DLLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELD 200 G + + H S L VQ L K+ +S V ++ V IE Sbjct: 127 LYPLLDGENILGGLHVPSDGLASAARAVQLLIKRT------ESAGVTYRGSTTVTGIEQS 180 Query: 201 NQGHVTGVVYMDENGNRKIMKSHHVVFCSGGFG 233 G VTGV ++ + VV C+G +G Sbjct: 181 G-GRVTGV-----QTADGVIPADIVVSCAGFWG 207 >4RPJ-A nrPDB Length = 399 Score = 39.9 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 14/44 (31%), Positives = 27/44 (61%) Query: 32 SMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSI 75 + + + V+GSG GLT + R+ ++ V++L++ IGGN+ Sbjct: 5 TARFDLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGGNAY 48 >2GAG-B nrPDB Length = 405 Score = 38.4 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 44/230 (19%), Positives = 81/230 (35%), Gaps = 42/230 (18%) Query: 30 QTSMKQPVVVIGSGLAGLTTSNRLISKYRI-PVVLLDKAASIGGNSIKASSGI--NGAHT 86 + +++G G GL T+ L + I V +L+K GGN + ++ I N Sbjct: 17 EPKKSYDAIIVGGGGHGLATAYFLAKNHGITNVAVLEKGWLAGGNMARNTTIIRSNYLWD 76 Query: 87 DTQ----QNLKVMDT-PELFLKDTLHSAKGR--------GVPSLMDKLTKESKSAIR--W 131 ++ ++LK+ + PE D L S +G V + ++ + + W Sbjct: 77 ESAGIYEKSLKLWEQLPEDLEYDFLFSQRGVLNLAHTLGDVRESVRRVEANKLNGVDAEW 136 Query: 132 LQTE--------FDLKLDLLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDS 183 L + D+ + G T + + + A ++K ++ Sbjct: 137 LDPSQVKEACPIINTSDDIRYPVMGA----TWQPRAGIAKHDHVAWAFARKANEMG---- 188 Query: 184 NLVQIMLNSEVVDIELDNQGHVTGVVYMDENGNRKIMKSHHVVFCSGGFG 233 V I+ N EV D + VTGV R + + V G Sbjct: 189 --VDIIQNCEVTGFIKDGE-KVTGV-----KTTRGTIHAGKVALAGAGHS 230 >5EZ7-A nrPDB Length = 392 Score = 38.4 bits (87), Expect = 0.008, Method: Composition-based stats. Identities = 35/212 (16%), Positives = 77/212 (36%), Gaps = 22/212 (10%) Query: 32 SMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGA------H 85 ++ ++++G G+AGL + RL + VL++ A+ GG S+K+ I+G Sbjct: 5 ALSTDILIVGGGIAGLWLNARL-RRAGYATVLVESASLGGGQSVKSQGIIHGGAKYALHG 63 Query: 86 TDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKE----SKSAIRWLQTEFDLKLD 141 T + + D P + + G + L++ S + T F Sbjct: 64 ALTGASEAIADMPRRW--RACLGSDGELDLRGVRLLSEAHYLWSPGGLAGSLTSFFASKA 121 Query: 142 LLAQL---GGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIE 198 + +++ G +P R G + + + + I +L E ++ Sbjct: 122 VRSRVEQAKGEDLPPALRDKGFKGKAYRLTEIVFDVPDLIRRLAELAGDSLLAGERIEPL 181 Query: 199 LDNQGHVTGVVYMDENGNRKIMKSHHVVFCSG 230 + + G+ +++ VV +G Sbjct: 182 REG-RELAGLCVDGRE-----IRAQRVVLSAG 207 >4IA5-A nrPDB Length = 591 Score = 38.4 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 14/43 (32%), Positives = 24/43 (55%), Gaps = 3/43 (6%) Query: 34 KQPVVVIGSGLAGLTTSNRLISKY---RIPVVLLDKAASIGGN 73 K+ +IGSGLAGL+T+ L+ + +L++ GG+ Sbjct: 22 KKSAYIIGSGLAGLSTAVFLVRDAQMKGENIHILEELPVAGGS 64 >3MJ4-A nrPDB Length = 397 Score = 37.6 bits (85), Expect = 0.014, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 25/46 (54%), Gaps = 1/46 (2%) Query: 30 QTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSI 75 Q S +++G+G AG + RL S V+++D+ IGGN+ Sbjct: 25 QESKGFDYLIVGAGFAGSVLAERLAS-SGQRVLIVDRRPHIGGNAY 69 >1SEZ-A nrPDB Length = 504 Score = 37.2 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 19/85 (22%), Positives = 37/85 (43%), Gaps = 4/85 (4%) Query: 23 RTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSI-KASSGI 81 +G D+ S + V VIG+G++GL + +L + + V + + GG + G+ Sbjct: 2 APSAGEDKHSSAKRVAVIGAGVSGLAAAYKL-KIHGLNVTVFEAEGKAGGKLRSVSQDGL 60 Query: 82 NGAHTDTQQNLKVMDTPELFLKDTL 106 + + + FL D+L Sbjct: 61 --IWDEGANTMTESEGDVTFLIDSL 83 >4JNQ-A nrPDB Length = 345 Score = 37.2 bits (84), Expect = 0.018, Method: Composition-based stats. Identities = 22/106 (20%), Positives = 38/106 (35%), Gaps = 13/106 (12%) Query: 21 LKRTLSGTDQTSMKQ-PVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASS 79 L+ G + + PV+VIGSG AG T + PVV+ + Sbjct: 12 LEAQTQGPGSMTQRHAPVIVIGSGPAGYTAAIYAARAMLKPVVI----------AGLQQG 61 Query: 80 GINGAHTDTQQNLKVMDTPE--LFLKDTLHSAKGRGVPSLMDKLTK 123 G TD + + + ++ A+ G + D +T+ Sbjct: 62 GQLMITTDVENYPGYAEPVQGPWMMEQMARQAENVGAQIVHDIITE 107 >3IHG-A nrPDB Length = 535 Score = 37.2 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 37/225 (16%), Positives = 75/225 (33%), Gaps = 23/225 (10%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMD 96 V+V+G+GL GL+T+ L + + V+++++ G + ++G N + + V D Sbjct: 8 VLVVGAGLGGLSTAMFLARQ-GVRVLVVERRP--GLSPYPRAAGQNPRTMELLRIGGVAD 64 Query: 97 TPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHSVPRTHR 156 E+ D + +G V L + + E + + + G + Sbjct: 65 --EVVRADDIRGTQGDFVIRLAESVRGEILRTVSESFDDMVAATEPCTPAGWAML----- 117 Query: 157 SSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMDEN-G 215 S KL P L + + I + ++ + GV Sbjct: 118 SQDKLEP------ILLAQARKHGGA------IRFGTRLLSFRQHDDDAGAGVTARLAGPD 165 Query: 216 NRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGD 260 +++ ++V G +E L L G D Sbjct: 166 GEYDLRAGYLVGADGNRSLVRESLGIGRYGHGTLTHMVGVIFDAD 210 >1F8S-A nrPDB Length = 498 Score = 36.8 bits (83), Expect = 0.023, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 25/46 (54%), Gaps = 1/46 (2%) Query: 27 GTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 G TS + VV++G+G+AGL+ + L V +L+ + GG Sbjct: 26 GLKATSNPKHVVIVGAGMAGLSAAYVLAG-AGHQVTVLEASERPGG 70 >4ZCC-A nrPDB Length = 336 Score = 36.1 bits (81), Expect = 0.033, Method: Composition-based stats. Identities = 18/50 (36%), Positives = 29/50 (58%), Gaps = 3/50 (6%) Query: 33 MKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG--NSIKASSG 80 M P+ +IG+G+AGL+ + L S V L DK+ GG +S ++ +G Sbjct: 1 MTVPIAIIGTGIAGLSAAQALTS-AGHQVHLFDKSRGSGGRMSSKRSDAG 49 >3OC4-A nrPDB Length = 452 Score = 36.1 bits (81), Expect = 0.033, Method: Composition-based stats. Identities = 16/57 (28%), Positives = 29/57 (50%), Gaps = 5/57 (8%) Query: 33 MKQPVVVIGSGLAGLTTSNRLISKY-RIPVVLLDKAASIGGNSIKASSGINGAHTDT 88 M +V+IG+ AG++ + KY + + L+DK A++G S G++ T Sbjct: 1 MSLKIVIIGASFAGISAAIASRKKYPQAEISLIDKQATVG----YLSGGLSAYFNHT 53 >5MOG-A nrPDB Length = 497 Score = 35.7 bits (80), Expect = 0.043, Method: Composition-based stats. Identities = 15/45 (33%), Positives = 25/45 (55%), Gaps = 1/45 (2%) Query: 28 TDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 ++Q + VV+ G+GLAGL+T+ L +LL+ +GG Sbjct: 11 SEQPTKPLQVVIAGAGLAGLSTAKYLAD-AGHKPILLEARDVLGG 54 >3L1R-A nrPDB Length = 478 Score = 35.7 bits (80), Expect = 0.046, Method: Composition-based stats. Identities = 49/287 (17%), Positives = 106/287 (36%), Gaps = 44/287 (15%) Query: 32 SMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKAS-SGIN---GAHTD 87 ++ V+V+G+G++G++ + RL +++L+ IGG K + +GIN GA+ Sbjct: 2 TVGPRVIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGGRMHKTNFAGINVELGANWV 61 Query: 88 TQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKE--SKSAIRWLQTEFD--LKLDLL 143 N M+ + TL R S D L + + + + ++L Sbjct: 62 EGVNGGKMNPIWPIVNSTLKL---RNFRSDFDYLAQNVYKEDGGVYDEDYVQKRIELADS 118 Query: 144 AQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQG 203 + G + T +SG+ + A+ + + + + V ++++ D E Sbjct: 119 VEEMGEKLSATLHASGRDDMS---ILAMQRLNEHQPNGPATPVDMVVDYYKFDYEFAEPP 175 Query: 204 HVTG------VVYMDENGNRKIMKSHH------VVFCSGGFGYSKE-------------- 237 VT + + G+ + V + +G + + + Sbjct: 176 RVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDKSGKIVDPRLQLNK 235 Query: 238 --MLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQVHP 282 +YSP + + T + + D + + LG D+ +Q P Sbjct: 236 VVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDL--IQFKP 280 >3KVE-A nrPDB Length = 486 Score = 35.7 bits (80), Expect = 0.050, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 26/46 (56%), Gaps = 1/46 (2%) Query: 27 GTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 G +TS + VVV+G+G++GL+ + L V +L+ + GG Sbjct: 26 GLKKTSNPKHVVVVGAGMSGLSAAYVLAG-AGHKVTVLEASERAGG 70 >1GPE-A nrPDB Length = 587 Score = 35.7 bits (80), Expect = 0.052, Method: Composition-based stats. Identities = 16/51 (31%), Positives = 26/51 (50%), Gaps = 1/51 (1%) Query: 18 IIVLKRTLSGTDQTSMKQPVVVI-GSGLAGLTTSNRLISKYRIPVVLLDKA 67 I V LS + + K +I G GL GLT + +L +I V++++K Sbjct: 7 IDVQSSLLSDPSKVAGKTYDYIIAGGGLTGLTVAAKLTENPKIKVLVIEKG 57 >3KKJ-A nrPDB Length = 336 Score = 35.3 bits (79), Expect = 0.056, Method: Composition-based stats. Identities = 17/50 (34%), Positives = 29/50 (58%), Gaps = 3/50 (6%) Query: 33 MKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG--NSIKASSG 80 M P+ +IG+G+AGL+ + L + V L DK+ GG +S ++ +G Sbjct: 1 MTVPIAIIGTGIAGLSAAQALTA-AGHQVHLFDKSRGSGGRMSSKRSDAG 49 >1RP0-A nrPDB Length = 284 Score = 35.3 bits (79), Expect = 0.065, Method: Composition-based stats. Identities = 13/46 (28%), Positives = 26/46 (56%) Query: 31 TSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIK 76 T + VVV+G+G AGL+ + + + V +++++ S GG + Sbjct: 36 TYAETDVVVVGAGSAGLSAAYEISKNPNVQVAIIEQSVSPGGGAWL 81 >5EVY-X nrPDB Length = 438 Score = 35.3 bits (79), Expect = 0.072, Method: Composition-based stats. Identities = 29/138 (21%), Positives = 44/138 (31%), Gaps = 16/138 (11%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLK--- 93 V VIG G+AG + L + V L + A + G S G+N + + Sbjct: 25 VAVIGGGIAGTALALGLSKSSHVNVKLFETAPAFGEIGAGVSFGVNAVEAIQRLGIGELY 84 Query: 94 --VMDTPELFLKDTLHSAKGRGVPSLMDKLTK--------ESKSAIRWLQTEFDLKLDLL 143 V D+ +D + SL+ I L+ + Sbjct: 85 KSVADSTPAPWQDIWFEWRHAHDASLVGATVAPGIGQSSIHRADFIDMLEKRLPAGI--- 141 Query: 144 AQLGGHSVPRTHRSSGKL 161 A LG H V T + G Sbjct: 142 ASLGKHVVDYTENAEGVT 159 >4X4J-A nrPDB Length = 507 Score = 34.9 bits (78), Expect = 0.077, Method: Composition-based stats. Identities = 32/160 (20%), Positives = 58/160 (36%), Gaps = 7/160 (4%) Query: 28 TDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTD 87 + M PVV+ G+G AGL + L I VV+L++ + G S G + Sbjct: 16 PRGSHMDAPVVIAGAGPAGLMLAGEL-RLAGIGVVVLERLPARTGESR--GLGFTARTME 72 Query: 88 TQQNLKVMDTP-ELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQL 146 ++ E+ D H L+D + +K+ + + + L+ A Sbjct: 73 VFDQRGLLRRFGEVQTSDQGHFGGIPVDFGLLDGAHQAAKTIPQ---SATEAVLEAWAGE 129 Query: 147 GGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLV 186 G + R H +G G + + + + LV Sbjct: 130 LGADIRRGHELTGVRDDGDGVAVTVRGPAGEHVLRAGWLV 169 >2JB2-A nrPDB Length = 489 Score = 34.9 bits (78), Expect = 0.086, Method: Composition-based stats. Identities = 16/44 (36%), Positives = 21/44 (47%), Gaps = 1/44 (2%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSG 80 VVV+G G AGL ++ L K V +L+ GG A G Sbjct: 14 VVVLGGGPAGLCSAFEL-QKAGYKVTVLEARTRPGGRVWTARGG 56 >5L3D-A nrPDB Length = 852 Score = 34.9 bits (78), Expect = 0.093, Method: Composition-based stats. Identities = 22/70 (31%), Positives = 36/70 (51%), Gaps = 5/70 (7%) Query: 5 VRRVFIYVSIFVLII--VLKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVV 62 V RV Y+ LI + KR + + K V++IGSG++GL + +L + + V Sbjct: 249 VHRVHSYLERHGLINFGIYKRIKPLPTKKTGK--VIIIGSGVSGLAAARQL-QSFGMDVT 305 Query: 63 LLDKAASIGG 72 LL+ +GG Sbjct: 306 LLEARDRVGG 315 >3ABT-A nrPDB Length = 662 Score = 34.9 bits (78), Expect = 0.093, Method: Composition-based stats. Identities = 22/70 (31%), Positives = 36/70 (51%), Gaps = 5/70 (7%) Query: 5 VRRVFIYVSIFVLII--VLKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVV 62 V RV Y+ LI + KR + + K V++IGSG++GL + +L + + V Sbjct: 78 VHRVHSYLERHGLINFGIYKRIKPLPTKKTGK--VIIIGSGVSGLAAARQL-QSFGMDVT 134 Query: 63 LLDKAASIGG 72 LL+ +GG Sbjct: 135 LLEARDRVGG 144 >1O5W-A nrPDB Length = 534 Score = 34.1 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 17/51 (33%), Positives = 30/51 (58%), Gaps = 1/51 (1%) Query: 25 LSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSI 75 L + VVVIG G++GL + +L+S+Y+I V++L+ +GG + Sbjct: 12 LEKPNLAGHMFDVVVIGGGISGLAAA-KLLSEYKINVLVLEARDRVGGRTY 61 >2BXR-A nrPDB Length = 527 Score = 34.1 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 14/39 (35%), Positives = 24/39 (61%), Gaps = 1/39 (2%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSI 75 VVVIG G++GL+ + L Y + V++L+ +GG + Sbjct: 16 VVVIGGGISGLSAAKLLTE-YGVSVLVLEARDRVGGRTY 53 >2GMH-A nrPDB Length = 584 Score = 33.7 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 16/52 (30%), Positives = 32/52 (61%), Gaps = 5/52 (9%) Query: 32 SMKQPVVVIGSGLAGLTTSNR---LISKYRI--PVVLLDKAASIGGNSIKAS 78 + + VV++G+G AGL+ + R L +++ V L++KAA IG +++ + Sbjct: 33 AEEADVVIVGAGPAGLSAATRLKQLAAQHEKDLRVCLVEKAAHIGAHTLSGA 84 >1REO-A nrPDB Length = 486 Score = 33.4 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 16/46 (34%), Positives = 26/46 (56%), Gaps = 1/46 (2%) Query: 27 GTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 G TS + VVV+G+G++GL+ + L S V +L+ + GG Sbjct: 26 GLKATSNPKHVVVVGAGMSGLSAAYVL-SGAGHQVTVLEASERAGG 70 >3FPZ-A nrPDB Length = 326 Score = 33.0 bits (73), Expect = 0.34, Method: Composition-based stats. Identities = 13/95 (13%), Positives = 37/95 (38%), Gaps = 5/95 (5%) Query: 37 VVVIGSGLAGLTTSNRLIS-KYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVM 95 V+++G+G +GL+ + + + + V +++ + + GG S + A + + Sbjct: 68 VIIVGAGSSGLSAAYVIAKNRPDLKVCIIESSVAPGGGSWLG-GQLFSAMVMRKPAHLFL 126 Query: 96 DTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIR 130 E+ +D V ++ ++ Sbjct: 127 QELEIPYEDE---GDYVVVKHAALFISTVLSKVLQ 158 >4ILK-A nrPDB Length = 359 Score = 33.0 bits (73), Expect = 0.35, Method: Composition-based stats. Identities = 39/188 (20%), Positives = 68/188 (36%), Gaps = 4/188 (2%) Query: 23 RTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGIN 82 ++G Q + V+V G+G GLT L Y + V++ SG + Sbjct: 170 ANVTGHGQPTENDTVLVYGAGPIGLTIVQVLKGVYNVKNVIVADRID-ERLEKAKESGAD 228 Query: 83 GAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDL 142 A ++Q L E +K TL PS++ + + A R + F + Sbjct: 229 WAINNSQTPLG-ESFAEKGIKPTLII-DAACHPSILKEAVTLASPAARIVLMGFSSEPSE 286 Query: 143 LAQLGGHSVPRTHRSSGKLPPGFEIV-QALSKKLKDISSKDSNLVQIMLNSEVVDIELDN 201 + Q G + SS F +V LSK L ++ ++ + + + Sbjct: 287 VIQQGITGKELSIFSSRLNANKFPVVIDWLSKGLIKPEKLITHTFDFQHVADAISLFELD 346 Query: 202 QGHVTGVV 209 Q H V+ Sbjct: 347 QKHCCKVL 354 >5MJK-A nrPDB Length = 327 Score = 32.6 bits (72), Expect = 0.41, Method: Composition-based stats. Identities = 16/46 (34%), Positives = 25/46 (54%), Gaps = 2/46 (4%) Query: 27 GTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 G+ T K VV+IGSG AG+T + + + +LL++ GG Sbjct: 17 GSHMTEKKYDVVIIGSGPAGMTAAMYTA-RSEMKTLLLERG-VPGG 60 >3CGD-A nrPDB Length = 480 Score = 32.6 bits (72), Expect = 0.45, Method: Composition-based stats. Identities = 19/166 (11%), Positives = 42/166 (25%), Gaps = 9/166 (5%) Query: 309 ILLHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNL 368 +L R L T + I A + + + + Sbjct: 167 LLKTIPDAERILKTLETNKVEDVTIIGGGAIGLEMAETFVE--LGKKVRMIERNDHIGTI 224 Query: 369 IKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVG 428 + ++ D +K++ +R + + + Sbjct: 225 YDGDMAEYIYKEADKHHIEILTNENVKAFKGN------ERVEAVETDKGTYKADLVLVSV 278 Query: 429 EVTPVVHFTMG-GVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVH 473 V P F G ++ N K + ++AAG+ + H Sbjct: 279 GVKPNTDFLEGTNIRTNHKGAIEVNAYMQTNVQDVYAAGDCATHYH 324 >2AAQ-A nrPDB Length = 479 Score = 32.6 bits (72), Expect = 0.45, Method: Composition-based stats. Identities = 23/167 (13%), Positives = 51/167 (30%), Gaps = 5/167 (2%) Query: 307 GGILLHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSK 366 G L + G EL R + + L + + + + Sbjct: 171 GASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSF--D 228 Query: 367 NLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVY 426 ++I +L S++ K+ S + P + + ++ Sbjct: 229 SMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLW 288 Query: 427 VG---EVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSG 470 T + G++ ++K +I ++ GI+A G+V G Sbjct: 289 AIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCG 335 >3JBO-G nrPDB Length = 224 Score = 32.2 bits (71), Expect = 0.47, Method: Composition-based stats. Identities = 22/110 (20%), Positives = 41/110 (37%), Gaps = 8/110 (7%) Query: 366 KNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTV 425 KN + + L+++ + + + L + D F +P + KD Sbjct: 1 KNWVPVTKLGRLVKEGKIVSIEEIYLHSLP-IKEYQIIDYFFQPNECSHPLKD------- 52 Query: 426 YVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGA 475 V ++ PV T G + K+ V + G+ A EV+ + GA Sbjct: 53 DVVKIMPVQKQTRAGQRTRFKAFVAIGDGNGHCGLGVKCAKEVATAIRGA 102 >3J7A-G nrPDB Length = 272 Score = 32.2 bits (71), Expect = 0.47, Method: Composition-based stats. Identities = 22/110 (20%), Positives = 41/110 (37%), Gaps = 8/110 (7%) Query: 366 KNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTV 425 KN + + L+++ + + + L + D F +P + KD Sbjct: 39 KNWVPVTKLGRLVKEGKIVSIEEIYLHSLP-IKEYQIIDYFFQPNECSHPLKD------- 90 Query: 426 YVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGA 475 V ++ PV T G + K+ V + G+ A EV+ + GA Sbjct: 91 DVVKIMPVQKQTRAGQRTRFKAFVAIGDGNGHCGLGVKCAKEVATAIRGA 140 >3RHA-A nrPDB Length = 482 Score = 32.2 bits (71), Expect = 0.51, Method: Composition-based stats. Identities = 13/43 (30%), Positives = 27/43 (62%), Gaps = 1/43 (2%) Query: 32 SMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNS 74 ++ + VV++G+G +GLT + R + K + V +L+ +GG + Sbjct: 5 NLDRDVVIVGAGPSGLTAA-RELKKAGLSVAVLEARDRVGGRT 46 >4UIR-A nrPDB Length = 646 Score = 32.2 bits (71), Expect = 0.53, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 22/49 (44%), Gaps = 3/49 (6%) Query: 28 TDQTSMKQPVVVIGSGLAGLTTSNRLISKY---RIPVVLLDKAASIGGN 73 Q+ + +IGSG+AG++ + I + L++ GG+ Sbjct: 56 PVQSYDNSKIYIIGSGIAGMSAAYYFIRDGHVPAKNITFLEQLHIDGGS 104 >2YVG-A nrPDB Length = 408 Score = 31.8 bits (70), Expect = 0.63, Method: Composition-based stats. Identities = 37/242 (15%), Positives = 74/242 (30%), Gaps = 17/242 (7%) Query: 29 DQTSMKQPVVVIGSGLAGLT--TSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHT 86 Q ++K PVVV+G+GLA ++ R + V+ D+A + + Sbjct: 2 SQEALKAPVVVLGAGLASVSFVAELRQAGYQGLITVVGDEAERPYDRPPLSKDFM-AHGD 60 Query: 87 DTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQL 146 + L PE ++ L P + ++ L+ Sbjct: 61 AEKIRLDCKRAPE--VEWLLGVTAQSFDPQAHTVALSDGRTL---------PYGTLVLAT 109 Query: 147 GGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVT 206 G PR + ++ L + + +++ V+ +EL Sbjct: 110 GAA--PRALPTLQGATMPVHTLRTLEDARRIQAGLRPQSRLLIVGGGVIGLELAATARTA 167 Query: 207 GV-VYMDENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKIL 265 GV V + E R + ++ Y + + +G DG +I Sbjct: 168 GVHVSLVETQPRLMSRAAPATLADFVARYHAAQGVDLRFERSVTGSVDGVVLLDDGTRIA 227 Query: 266 SK 267 + Sbjct: 228 AD 229 >3ATQ-A nrPDB Length = 453 Score = 31.8 bits (70), Expect = 0.68, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 21/36 (58%), Gaps = 1/36 (2%) Query: 33 MKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAA 68 +K V++IG G AG + + +L + + ++L+D Sbjct: 5 LKYDVLIIGGGFAGSSAAYQLSRR-GLKILLVDSKP 39 >4YNU-A nrPDB Length = 571 Score = 31.4 bits (69), Expect = 0.83, Method: Composition-based stats. Identities = 20/96 (20%), Positives = 40/96 (41%), Gaps = 3/96 (3%) Query: 38 VVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASS---GINGAHTDTQQNLKV 94 +V+G G +GL +NRL + V+LL+ AS+ N ++ G+ Q + Sbjct: 9 IVVGGGTSGLVVANRLSENPDVSVLLLEAGASVFNNPDVTNANGYGLAFGSAIDWQYQSI 68 Query: 95 MDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIR 130 + + L + K G S ++ + ++ Sbjct: 69 NQSYAGGKQQVLRAGKALGGTSTINGMAYTRAEDVQ 104 >4RG3-A nrPDB Length = 548 Score = 31.4 bits (69), Expect = 0.84, Method: Composition-based stats. Identities = 17/53 (32%), Positives = 27/53 (50%) Query: 21 LKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGN 73 L+ ++ T QT+ VVIG+G G+ ++L + + V DKA GG Sbjct: 3 LEASMHMTAQTTHTVDAVVIGAGFGGIYAVHKLHHELGLTTVGFDKADGPGGT 55 >4C5O-A nrPDB Length = 357 Score = 31.4 bits (69), Expect = 0.84, Method: Composition-based stats. Identities = 16/36 (44%), Positives = 21/36 (58%), Gaps = 1/36 (2%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 VVVIG G +GL+ L + + V+LD AS GG Sbjct: 6 VVVIGGGQSGLSAGYFL-RRSGLSYVILDAEASPGG 40 >3BI4-A nrPDB Length = 516 Score = 31.4 bits (69), Expect = 0.87, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 31/72 (43%) Query: 34 KQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLK 93 K+ V++IG+G+AGL ++ L ++L+ +GG + + Sbjct: 8 KKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGRKYDIGASWHH 67 Query: 94 VMDTPELFLKDT 105 T LFL++ Sbjct: 68 DTLTNPLFLEEA 79 >2GV8-A nrPDB Length = 447 Score = 31.4 bits (69), Expect = 0.89, Method: Composition-based stats. Identities = 13/39 (33%), Positives = 20/39 (51%), Gaps = 1/39 (2%) Query: 35 QPVVVIGSGLAGL-TTSNRLISKYRIPVVLLDKAASIGG 72 + + +IG+G +GL T L K V L ++ S GG Sbjct: 7 RKIAIIGAGPSGLVTAKALLAEKAFDQVTLFERRGSPGG 45 >5X1Y-B nrPDB Length = 554 Score = 31.4 bits (69), Expect = 0.92, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 20/35 (57%), Gaps = 1/35 (2%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIG 71 +++IGSG A +++ + I Y V ++++ G Sbjct: 87 LLIIGSGAAAFSSAIKAIE-YGAKVGMIERGTVGG 120 >5Y77-A nrPDB Length = 473 Score = 31.4 bits (69), Expect = 0.95, Method: Composition-based stats. Identities = 13/40 (32%), Positives = 21/40 (52%), Gaps = 1/40 (2%) Query: 31 TSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASI 70 T + V +IG+GLAG T RL+++ V L ++ Sbjct: 5 TDNARQVTIIGAGLAG-TLVARLLARNGWQVNLFERRPDP 43 >4V6B-AA nrPDB Length = 192 Score = 31.0 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 18/63 (28%) Query: 86 TDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQ 145 + + + L D R P L D L L + L L + Sbjct: 96 DAMKAAMALEKKLNQALLDLHALGSARTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHR 155 Query: 146 LGG 148 LGG Sbjct: 156 LGG 158 >3F8P-A nrPDB Length = 323 Score = 31.0 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 11/69 (15%), Positives = 25/69 (36%), Gaps = 1/69 (1%) Query: 431 TPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFG 490 P G++ + + G+FAAG+ + G R +++ + V Sbjct: 251 PPTDFAKSNGIETDTNGYIKVDEWMRTSVPGVFAAGDCTSAWLGF-RQVITAVAQGAVAA 309 Query: 491 KTAADNIAK 499 +A + + Sbjct: 310 TSAYRYVTE 318 >3R9U-A nrPDB Length = 315 Score = 31.0 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 16/36 (44%), Gaps = 1/36 (2%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 V +IG G AGL+ VV+ +K GG Sbjct: 7 VAIIGGGPAGLSAGLYATRGGLKNVVMFEKG-MPGG 41 >1I8T-A nrPDB Length = 367 Score = 30.7 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 14/38 (36%), Positives = 23/38 (60%), Gaps = 1/38 (2%) Query: 38 VVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSI 75 +++GSGL G +N L K V++++K IGGN+ Sbjct: 5 IIVGSGLFGAVCANEL-KKLNKKVLVIEKRNHIGGNAY 41 >1FOH-A nrPDB Length = 664 Score = 30.7 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 16/75 (21%), Positives = 32/75 (42%), Gaps = 12/75 (16%) Query: 37 VVVIGSGLAGLTTSNRLIS----KYRIPVVLLDKAASIGGNSIKASS---GINGAHTDTQ 89 V+++G+G AGL + L K + V ++DK ++ + G+ ++ Sbjct: 10 VLIVGAGPAGLMAARVLSEYVRQKPDLKVRIIDKR-----STKVYNGQADGLQCRTLESL 64 Query: 90 QNLKVMDTPELFLKD 104 +NL + D D Sbjct: 65 KNLGLADKILSEAND 79 >1PS9-A nrPDB Length = 671 Score = 30.7 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 14/46 (30%), Positives = 22/46 (47%), Gaps = 1/46 (2%) Query: 33 MKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKAS 78 K+ + V+G+G AGL + ++ V L D + IGG A Sbjct: 372 QKKNLAVVGAGPAGLAFAINAAAR-GHQVTLFDAHSEIGGQFNIAK 416 >4IV9-A nrPDB Length = 557 Score = 30.7 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 12/44 (27%), Positives = 21/44 (47%) Query: 29 DQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 + V ++G+G++GL + L+ VVL + IGG Sbjct: 33 SAGTPTPRVAIVGAGISGLVAATELLRAGVKDVVLYESRDRIGG 76 >6N7F-A nrPDB Length = 453 Score = 30.3 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 25/168 (14%), Positives = 57/168 (33%), Gaps = 9/168 (5%) Query: 306 LGGILLHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMS 365 G + G +E+ R V L ++ + + + Sbjct: 152 EGAQYGISSDGFFALDEVPKRTAVVGAGYIAVELAGVLHALGSKTDLFIRHDRPLRSF-- 209 Query: 366 KNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFD-RPLIINAFDKDISTEST 424 I V ++++ T +E+ +K+ + T D + + ++ I + Sbjct: 210 DKTIVDVLVDEMAVNGPRLHTHAEVAKVVKNTDESLTLYLKDGQEVEVDQLIWAIGRKPN 269 Query: 425 VYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGV 472 + + GV +N+K + E+ GI+A G+V+G + Sbjct: 270 LEGFSLDKT------GVTLNDKGYIETDAYENTSVKGIYAVGDVNGKL 311 Score = 28.4 bits (61), Expect = 7.7, Method: Composition-based stats. Identities = 14/36 (38%), Positives = 20/36 (55%), Gaps = 2/36 (5%) Query: 38 VVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGN 73 +VIG G AG+ ++NR + V LL + IGG Sbjct: 11 IVIGGGSAGIASANRAA-MHGAKV-LLAEGKEIGGT 44 >2BKW-A nrPDB Length = 385 Score = 30.3 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 26/63 (41%), Gaps = 3/63 (4%) Query: 11 YVSIFVLIIVLKRTLSGTDQTSMKQPVVVIGSGLAG---LTTSNRLISKYRIPVVLLDKA 67 +VSIF ++ R + + S QP V+ GSG G ++ L V+++ Sbjct: 36 FVSIFQRVLKNTRAVFKSAAASKSQPFVLAGSGTLGWDIFASNFILSKAPNKNVLVVSTG 95 Query: 68 ASI 70 Sbjct: 96 TFS 98 >4PLW-A nrPDB Length = 326 Score = 30.3 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 19/96 (19%), Positives = 37/96 (38%), Gaps = 8/96 (8%) Query: 32 SMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLD--------KAASIGGNSIKASSGING 83 + ++ + +IG+G G T ++ + K VVL D KA I +S S + Sbjct: 2 TQRKKISLIGAGNIGGTLAHLIAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKI 61 Query: 84 AHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMD 119 T+ +++K D + R ++ Sbjct: 62 TGTNNYEDIKGSDVVIITAGIPRKPGMSRDDLLSVN 97 >1GAL-A nrPDB Length = 583 Score = 30.3 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 26/127 (20%), Positives = 50/127 (39%), Gaps = 8/127 (6%) Query: 20 VLKRTLSGTDQTSMKQPVVVI-GSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKAS 78 + L+ S + +I G GL GLTT+ RL I V++++ + Sbjct: 4 IEASLLTDPKDVSGRTVDYIIAGGGLTGLTTAARLTENPNISVLVIESGSYESDRGPIIE 63 Query: 79 SGINGAHTDTQQNLK-VMDTPELFLKDT---LHSAKGRGVPSLMD--KLTKESKSAIRWL 132 +N ++ +T EL + + S G G +L++ T+ K+ + Sbjct: 64 D-LNAYGDIFGSSVDHAYETVELATNNQTALIRSGNGLGGSTLVNGGTWTRPHKAQVDSW 122 Query: 133 QTEFDLK 139 +T F + Sbjct: 123 ETVFGNE 129 >3NIX-A nrPDB Length = 421 Score = 30.3 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 13/38 (34%), Positives = 21/38 (55%), Gaps = 1/38 (2%) Query: 33 MKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASI 70 K V+VIG+G AG T + L++K V +++K Sbjct: 4 EKVDVLVIGAGPAG-TVAASLVNKSGFKVKIVEKQKFP 40 >4CBQ-A nrPDB Length = 314 Score = 29.9 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 26/64 (40%), Gaps = 1/64 (1%) Query: 410 LIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVS 469 +++ K + Y +P F G VK + ++ + +G+FA G+V Sbjct: 228 NLVSGEYKVVPVAGLFYAIGHSPNSKFLGGQVKTADDGYILTE-GPKTSVDGVFACGDVC 286 Query: 470 GGVH 473 V+ Sbjct: 287 DRVY 290 >5TR3-A nrPDB Length = 481 Score = 29.9 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 22/44 (50%) Query: 429 EVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGV 472 VT + + GV I+E+ + + + G++A G+V G+ Sbjct: 284 PVTTDLLASDSGVTIDERGYIFVDDYCATSVPGVYAIGDVVRGM 327 Score = 28.7 bits (62), Expect = 6.7, Method: Composition-based stats. Identities = 12/49 (24%), Positives = 20/49 (40%), Gaps = 3/49 (6%) Query: 32 SMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSG 80 + K VVVIG+G G + + + + ++K G A G Sbjct: 5 TQKFDVVVIGAGPGGYVAAIKAA-QLGLKTACIEKYTDAEG--KLALGG 50 >3TL2-A nrPDB Length = 315 Score = 29.9 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 15/35 (42%), Positives = 20/35 (57%) Query: 31 TSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLD 65 T ++ V VIG+G G TT+ L K VVL+D Sbjct: 5 TIKRKKVSVIGAGFTGATTAFLLAQKELADVVLVD 39 >5XYI-C nrPDB Length = 272 Score = 29.9 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 14/72 (19%), Positives = 28/72 (38%) Query: 413 NAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGV 472 + + + + ++ PV T G + K+ + + + GI A EV+ + Sbjct: 81 EIVEHLLGEDLKDEIMKIMPVQKQTRAGQRTRFKAIAAVGDGKGHIGLGIKTAAEVANAI 140 Query: 473 HGANRLGGSSLL 484 GA S+L Sbjct: 141 KGATIYAKLSIL 152 >3IHM-A nrPDB Length = 430 Score = 29.9 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 15/73 (20%), Positives = 30/73 (41%), Gaps = 3/73 (4%) Query: 28 TDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVL-LDKAASI-GGNSIKASSGINGAH 85 + MK+ + ++G+G AGL L ++ + V + D+ G + + N Sbjct: 16 PRGSHMKKRIGIVGAGTAGLHLGLFL-RQHDVDVTVYTDRKPDEYSGLRLLNTVAHNAVT 74 Query: 86 TDTQQNLKVMDTP 98 + L V + P Sbjct: 75 VQREVALDVNEWP 87 >1C0L-A nrPDB Length = 363 Score = 29.9 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 14/53 (26%), Positives = 23/53 (43%) Query: 34 KQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHT 86 ++ VVV+GSG+ GL+++ L K +L + AS T Sbjct: 6 QKRVVVLGSGVIGLSSALILARKGYSVHILARDLPEDVSSQTFASPWAGANWT 58 >4UDQ-A nrPDB Length = 531 Score = 29.5 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 12/38 (31%), Positives = 21/38 (55%) Query: 38 VVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSI 75 V++G G AG +NRL ++ V+L++ N+I Sbjct: 9 VIVGGGTAGSVLANRLSARPENRVLLIEAGIDTPENNI 46 >4H7U-A nrPDB Length = 602 Score = 29.5 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 17/32 (53%) Query: 38 VVIGSGLAGLTTSNRLISKYRIPVVLLDKAAS 69 +V G G AGL ++RL V++++ S Sbjct: 44 IVAGGGTAGLVVASRLSENSNWKVLVIEAGPS 75 >3IC9-A nrPDB Length = 492 Score = 29.5 bits (64), Expect = 3.2, Method: Composition-based stats. Identities = 12/32 (37%), Positives = 19/32 (59%), Gaps = 1/32 (3%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAA 68 V +IG+G AG+ + R K+ VVL++ A Sbjct: 11 VAIIGTGTAGMG-AYRAAKKHTDKVVLIEGGA 41 >4NTC-A nrPDB Length = 335 Score = 29.5 bits (64), Expect = 3.2, Method: Composition-based stats. Identities = 11/26 (42%), Positives = 17/26 (65%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVV 62 V++IG+G AGL+T+ L + VV Sbjct: 17 VLIIGAGPAGLSTATGLARQLHTAVV 42 >5CEE-A nrPDB Length = 413 Score = 29.5 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 29/130 (22%), Positives = 54/130 (41%), Gaps = 15/130 (11%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMD 96 VV+ G+G AG+ + L+ VVL+DK + G+ + ++ ++V + Sbjct: 210 VVINGAGSAGMAIAKMLLLLKVNNVVLVDK-------TGTLYKGVANLNEPQKKLVEVTN 262 Query: 97 TPELF--LKDTLHSAK---GRGVPSLM--DKLTKESKSAIRW-LQTEFDLKLDLLAQLGG 148 + LK+ L G P ++ + + +K AI + L + A+ GG Sbjct: 263 KYQEKGTLKEVLKGKDIFIGVSAPGIVTAEMVATMAKDAIVFALANPVPEIMPDEAKKGG 322 Query: 149 HSVPRTHRSS 158 + T RS Sbjct: 323 ARIVATGRSD 332 >4YRY-B nrPDB Length = 468 Score = 29.5 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 29/115 (25%), Positives = 35/115 (30%), Gaps = 19/115 (16%) Query: 28 TDQTSMKQPVVVIGSGLAGLTTSNRLISK------------------YRIPVVLLDKAAS 69 S K+ V V+GSG AGLT + L Y IP L K Sbjct: 134 PLAGSKKEKVAVVGSGPAGLTAAADLAKMGYHVDIFEAFHKPGGVLVYGIPEFRLPKRIV 193 Query: 70 IGGNSIKASSGINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKE 124 S G+N H +T V L D + G G P M Sbjct: 194 EREVSYIRKLGVN-FHLNTVVGKTVKVKELLSEYDAVFIGTGAGTPKFMGIPGTN 247 >3UKH-A nrPDB Length = 519 Score = 29.5 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 19/36 (52%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 V+VIG+G GL + RL +++D + GG Sbjct: 9 VLVIGAGPTGLGAAKRLNQIDGPSWMIVDSNETPGG 44 >5Z70-A nrPDB Length = 605 Score = 29.5 bits (64), Expect = 3.4, Method: Composition-based stats. Identities = 14/38 (36%), Positives = 23/38 (60%), Gaps = 3/38 (7%) Query: 39 VIGSGLAGLTTSNRLISKYRIP---VVLLDKAASIGGN 73 +IGSG+AGL ++ LI R+ + +LD + GG+ Sbjct: 9 IIGSGIAGLASAFYLIRDGRMKGQDITILDAVGTPGGS 46 >3ISH-A nrPDB Length = 311 Score = 29.5 bits (64), Expect = 3.6, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 14/34 (41%), Gaps = 1/34 (2%) Query: 39 VIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 +IG G AGL+ VL +K GG Sbjct: 6 IIGGGPAGLSAGLYATRGGVKNAVLFEKG-MPGG 38 >2DZD-A nrPDB Length = 461 Score = 29.5 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 22/158 (13%), Positives = 45/158 (28%), Gaps = 4/158 (2%) Query: 275 MDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGR--RFTNELSTRDTVTME 332 ++ + H I P + A+ R G I + P F +++ R Sbjct: 72 IEIAKAHDVDAIHPGYGFLSENIQFAKRCREEGIIFIGPNENHLDMFGDKVKARHAAVNA 131 Query: 333 IQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVT 392 P +D + D V + + L ++R A E Sbjct: 132 GIPVIPGSDGPVDGLE-DVVAFAEAHGYPIIIKAALGGGGRGMRIVRSKSEVKEAFERAK 190 Query: 393 ELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEV 430 ++ + + + + LI N ++ V Sbjct: 191 -SEAKAAFGSDEVYVEKLIENPKHIEVQILGDYEGNIV 227 >4Z25-A nrPDB Length = 652 Score = 29.1 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 9/31 (29%), Positives = 18/31 (58%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKA 67 +V+IG+G AG ++ L + ++LL+ Sbjct: 9 IVIIGAGAAGSLLAHYLARFSNMKIILLEAG 39 >5NCC-A nrPDB Length = 594 Score = 29.1 bits (63), Expect = 4.1, Method: Composition-based stats. Identities = 15/80 (18%), Positives = 30/80 (37%) Query: 33 MKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNL 92 K +++G G A +NRL + V++L+ +K + I Sbjct: 22 QKYDYILVGGGTAACVLANRLSADGSKRVLVLEAGPDNTSRDVKIPAAITRLFRSPLDWN 81 Query: 93 KVMDTPELFLKDTLHSAKGR 112 + E + ++ A+GR Sbjct: 82 LFSELQEQLAERQIYMARGR 101 >4JDR-A nrPDB Length = 474 Score = 29.1 bits (63), Expect = 4.2, Method: Composition-based stats. Identities = 13/42 (30%), Positives = 25/42 (59%), Gaps = 1/42 (2%) Query: 31 TSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 T +K VVV+G+G AG + + R + V++++ ++GG Sbjct: 3 TEIKTQVVVLGAGPAGYSAAFRCAD-LGLETVIVERYNTLGG 43 >2TMD-A nrPDB Length = 729 Score = 29.1 bits (63), Expect = 4.3, Method: Composition-based stats. Identities = 15/43 (34%), Positives = 25/43 (58%), Gaps = 1/43 (2%) Query: 30 QTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 QT K V+++G+G +G + + R++ + V L D A IGG Sbjct: 385 QTKNKDSVLIVGAGPSG-SEAARVLMESGYTVHLTDTAEKIGG 426 >3FLC-O nrPDB Length = 518 Score = 29.1 bits (63), Expect = 4.4, Method: Composition-based stats. Identities = 27/129 (20%), Positives = 50/129 (38%), Gaps = 22/129 (17%) Query: 32 SMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIK---ASSGINGAHTDT 88 +++ + V GS + L R+I L KA G N + A +G+ + D+ Sbjct: 314 ALEGSIFVAGSAIQWLRDGLRMIETSPQSEELAAKA--KGDNEVYVVPAFTGLGAPYWDS 371 Query: 89 QQNLKV-----MDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLL 143 + V T E F++ TL + + +SK I ++ + + + LL Sbjct: 372 EARGAVFGLTRGTTKEDFVRATLQA------------VAYQSKDVIDTMKKDSGIDIPLL 419 Query: 144 AQLGGHSVP 152 GG + Sbjct: 420 KVDGGAAKN 428 >5J7X-A nrPDB Length = 549 Score = 29.1 bits (63), Expect = 4.5, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 22/36 (61%) Query: 38 VVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGN 73 ++IGSG +G+ ++L + ++ V + + + IGG Sbjct: 16 LIIGSGFSGIYLLHKLRDELKLKVKIFEAESDIGGT 51 >1GEU-A nrPDB Length = 450 Score = 29.1 bits (63), Expect = 4.6, Method: Composition-based stats. Identities = 12/33 (36%), Positives = 19/33 (57%) Query: 440 GVKINEKSQVIKKNSESVLSNGIFAAGEVSGGV 472 GVK NEK ++ ++ GI+A G+ +G V Sbjct: 276 GVKTNEKGYIVVDKYQNTNIEGIYAVGDNTGAV 308 >5XXU-C nrPDB Length = 269 Score = 29.1 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 23/107 (21%), Positives = 39/107 (36%), Gaps = 8/107 (7%) Query: 369 IKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVG 428 + + L+R + + + L + D F +P A KD V Sbjct: 38 VPITKLGRLVRDGKISSIEEIYLFSLP-IKEYQIIDHFFQPGNCAAPLKD-------DVM 89 Query: 429 EVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGA 475 ++ PV T G + K+ V +S G+ A EV+ + GA Sbjct: 90 KIMPVQKQTRAGQRTRFKAFVAVGDSNGHCGLGVKCAKEVATAIRGA 136 >3LAD-A nrPDB Length = 476 Score = 29.1 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 17/73 (23%), Positives = 29/73 (39%), Gaps = 3/73 (4%) Query: 429 EVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVV 488 VT + GV ++E+ + + + G++A G+V V GA +S VV Sbjct: 280 PVTTDLLAADSGVTLDERGFIYVDDYCATSVPGVYAIGDV---VRGAMLAHKASEEGVVV 336 Query: 489 FGKTAADNIAKLY 501 + A Y Sbjct: 337 AERIAGHKAQMNY 349 >2YQU-A nrPDB Length = 455 Score = 29.1 bits (63), Expect = 5.0, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 21/37 (56%), Gaps = 1/37 (2%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGN 73 ++VIG+G G + R + + V +++K ++GG Sbjct: 4 LLVIGAGPGGYVAAIRAA-QLGMKVGVVEKEKALGGT 39 >2Q7V-A nrPDB Length = 325 Score = 29.1 bits (63), Expect = 5.0, Method: Composition-based stats. Identities = 15/45 (33%), Positives = 24/45 (53%), Gaps = 2/45 (4%) Query: 28 TDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 T T+ VV+IG G AGLT + + ++ ++L+K GG Sbjct: 2 TAPTAHDYDVVIIGGGPAGLTAAI-YTGRAQLSTLILEKG-MPGG 44 >4OVI-A nrPDB Length = 542 Score = 29.1 bits (63), Expect = 5.1, Method: Composition-based stats. Identities = 14/51 (27%), Positives = 26/51 (50%), Gaps = 1/51 (1%) Query: 22 KRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 + T+ Q + V+V+G+G +GL RL + V +++ A +GG Sbjct: 4 QTTVDSRRQPPEEVDVLVVGAGFSGLYALYRL-RELGRSVHVIETAGDVGG 53 >5TUF-A nrPDB Length = 409 Score = 28.7 bits (62), Expect = 5.3, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 31/76 (40%), Gaps = 11/76 (14%) Query: 27 GTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSG----IN 82 G+ + ++VIG G+AG + L ++ VL++K ++ G I Sbjct: 18 GSHMMTKHIKILVIGVGVAGPAVAYWL-KRFGFSPVLIEK------SAAVRKGGQALDIR 70 Query: 83 GAHTDTQQNLKVMDTP 98 G T + + + D Sbjct: 71 GIATHIAKEMGIYDQI 86 >1F6M-A nrPDB Length = 320 Score = 28.7 bits (62), Expect = 5.3, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 17/33 (51%) Query: 31 TSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVL 63 T+ ++++GSG AG T + PV++ Sbjct: 2 TTKHSKLLILGSGPAGYTAAVYAARANLQPVLI 34 >5J7I-A nrPDB Length = 488 Score = 28.7 bits (62), Expect = 5.3, Method: Composition-based stats. Identities = 37/272 (13%), Positives = 75/272 (27%), Gaps = 16/272 (5%) Query: 221 KSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQV 280 K V+ +GG G K P + N + I + + Sbjct: 212 KLTDVILATGGPGLVKAAYSSGKPAY-GVGPGNVPVYIHESANIAKAVQLIIQSKTFDYG 270 Query: 281 HPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTMEIQSKCPK- 339 + + K L+ G L+ ++ + + ++ +I K P+ Sbjct: 271 TICASEQALLVDESIKEKVVAELKQQGAYFLNEEEKQKVASIIMVNGSLNAKIVGKAPQV 330 Query: 340 -NDNRALLVMSD-KVYENYTNNINFYMSKNLIKKVSI------------NDLIRQYDLQT 385 + + + SD K+ + ++ K I ++L ++ Sbjct: 331 IAEMAGIEIPSDVKLLVAEETEVGKEYPFSIEKLSPILAFYIVKGMEEASELAQKLLEVG 390 Query: 386 TASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINE 445 V V T D+P + + V P + G + N Sbjct: 391 GLGHTVGIHAEDEKVIEAYTIDKPAGRIVVNAGTTFGGIGATVNVKPSLTLGCGAIGNNI 450 Query: 446 KSQVIKKNSESVLSNGIFAAGEVSGGVHGANR 477 S + + F E+ V GA + Sbjct: 451 TSDNVTVTHLFNIKRVAFGVREMPKKVEGAQK 482 >1DOD-A nrPDB Length = 394 Score = 28.7 bits (62), Expect = 5.5, Method: Composition-based stats. Identities = 11/37 (29%), Positives = 16/37 (43%) Query: 33 MKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAAS 69 MK V +IG+G +GL L V+L + Sbjct: 1 MKTQVAIIGAGPSGLLLGQLLHKAGIDNVILERQTPD 37 >3K30-A nrPDB Length = 690 Score = 28.7 bits (62), Expect = 5.9, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 1/36 (2%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 V+V+G+G +GL + L + VVL + +GG Sbjct: 394 VLVVGAGPSGLEAARALGVR-GYDVVLAEAGRDLGG 428 >3JSK-A nrPDB Length = 344 Score = 28.7 bits (62), Expect = 6.3, Method: Composition-based stats. Identities = 11/69 (15%), Positives = 31/69 (44%), Gaps = 2/69 (2%) Query: 37 VVVIGSGLAGLTTSNRLIS-KYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVM 95 +V++G+G GL+ + L + + + + +++ + GG + + A + + Sbjct: 82 IVIVGAGSCGLSAAYVLSTLRPDLRITIVEAGVAPGGGAWLG-GQLFSAMVMRKPADVFL 140 Query: 96 DTPELFLKD 104 D + +D Sbjct: 141 DEVGVPYED 149 >5VDN-A nrPDB Length = 463 Score = 28.7 bits (62), Expect = 6.5, Method: Composition-based stats. Identities = 12/60 (20%), Positives = 29/60 (48%), Gaps = 3/60 (5%) Query: 416 DKDISTESTVYVGEVTPV---VHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGV 472 +++ + ++ P ++ ++ GVK N+K + ++ GI+A G+ +G V Sbjct: 262 GTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYAVGDNTGVV 321 >6ER9-A nrPDB Length = 549 Score = 28.4 bits (61), Expect = 7.2, Method: Composition-based stats. Identities = 23/86 (26%), Positives = 37/86 (43%), Gaps = 2/86 (2%) Query: 38 VVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDT 97 VVIG+G G+ ++L ++ + VV DKA GG GA +DT+ +L Sbjct: 13 VVIGAGFGGIYAVHKLHNEQGLTVVGFDKADGPGGTWYWNR--YPGALSDTESHLYRFSF 70 Query: 98 PELFLKDTLHSAKGRGVPSLMDKLTK 123 L+D P +++ L Sbjct: 71 DRDLLQDGTWKTTYITQPEILEYLES 96 >2VHY-A nrPDB Length = 377 Score = 28.4 bits (61), Expect = 7.9, Method: Composition-based stats. Identities = 14/44 (31%), Positives = 20/44 (45%), Gaps = 1/44 (2%) Query: 22 KRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLD 65 + L G VVVIG+G AG + R+ + V +LD Sbjct: 156 RGVLMGGVPGVEPADVVVIGAGTAGYNAA-RIANGMGATVTVLD 198 >6BWT-A nrPDB Length = 319 Score = 28.4 bits (61), Expect = 8.1, Method: Composition-based stats. Identities = 8/32 (25%), Positives = 15/32 (46%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAA 68 ++++GSG AG T + PV++ Sbjct: 10 LIILGSGPAGYTAAIYAARANLKPVIITGMQP 41 >4GCM-A nrPDB Length = 312 Score = 28.4 bits (61), Expect = 8.3, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 23/42 (54%), Gaps = 2/42 (4%) Query: 31 TSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 T + + +IG+G AG+T + S+ + V++++ GG Sbjct: 3 TEIDFDIAIIGAGPAGMTAAV-YASRANLKTVMIERG-IPGG 42 >2CVJ-A nrPDB Length = 180 Score = 28.4 bits (61), Expect = 8.5, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 19/31 (61%), Gaps = 1/31 (3%) Query: 37 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKA 67 V+V+G G +GL+ + L + + V++LD Sbjct: 4 VIVVGGGPSGLSAALFLA-RAGLKVLVLDGG 33 >1VRQ-A nrPDB Length = 964 Score = 28.4 bits (61), Expect = 8.6, Method: Composition-based stats. Identities = 16/63 (25%), Positives = 22/63 (34%), Gaps = 5/63 (7%) Query: 52 RLISKYRIPVVLLDKAASIGGNSIKASS----GINGA-HTDTQQNLKVMDTPELFLKDTL 106 R S+ V+LLD+ GG +AS GI+ A D L+ T Sbjct: 144 REASRSGARVMLLDERPEAGGTLREASGEQIDGIDAAQWIDAVTEELAAAEETTHLQRTT 203 Query: 107 HSA 109 Sbjct: 204 VFG 206 >4Y4N-A nrPDB Length = 286 Score = 28.0 bits (60), Expect = 9.4, Method: Composition-based stats. Identities = 12/55 (21%), Positives = 23/55 (41%), Gaps = 1/55 (1%) Query: 445 EKSQVIKKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIAK 499 EK + + + G+F G + V+ +R+G + GK A+ I + Sbjct: 227 EKGENALLRNTREVYPGLFVCGMAANAVYAGHRMGA-IFGGMYISGKKCAEMIVE 280 >5U8W-A nrPDB Length = 481 Score = 28.0 bits (60), Expect = 9.6, Method: Composition-based stats. Identities = 17/73 (23%), Positives = 28/73 (38%), Gaps = 3/73 (4%) Query: 429 EVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVV 488 VT + GV ++E+ + + G+FA G+V V GA +S +V Sbjct: 284 PVTTDLLAADSGVTLDERGFIYVDDHCKTSVPGVFAIGDV---VRGAMLAHKASEEGVMV 340 Query: 489 FGKTAADNIAKLY 501 + A Y Sbjct: 341 AERIAGHKAQMNY 353 >4AP1-A nrPDB Length = 549 Score = 28.0 bits (60), Expect = 9.9, Method: Composition-based stats. Identities = 16/53 (30%), Positives = 29/53 (54%), Gaps = 3/53 (5%) Query: 22 KRTLSGTDQTS--MKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 72 + ++ D T+ VVV+G+G+AGL +R S+ + V + A+ +GG Sbjct: 7 RSVVTAPDATTGTTSYDVVVVGAGIAGLYAIHRFRSQ-GLTVRAFEAASGVGG 58 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.113 0.273 Lambda K H 0.267 0.0351 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,162,514 Number of Sequences: 36641 Number of extensions: 562755 Number of successful extensions: 3537 Number of sequences better than 10.0: 150 Number of HSP's better than 10.0 without gapping: 99 Number of HSP's successfully gapped in prelim test: 115 Number of HSP's that attempted gapping in prelim test: 3237 Number of HSP's gapped (non-prelim): 269 length of query: 501 length of database: 10,336,785 effective HSP length: 101 effective length of query: 400 effective length of database: 6,636,044 effective search space: 2654417600 effective search space used: 2654417600 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 61 (28.3 bits)