BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P21146 (689 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3PVW-A nrPDB 1430 0.0 5UUU-A nrPDB 1066 0.0 3NYO-A nrPDB 304 8e-83 4TNB-A nrPDB 303 2e-82 4YHJ-A nrPDB 291 9e-79 3C51-A nrPDB 267 1e-71 5D9K-A nrPDB 213 2e-55 2Z7Q-A nrPDB 213 3e-55 2JDO-A nrPDB 211 9e-55 1VZO-A nrPDB 207 1e-53 5KCV-A nrPDB 202 3e-52 3MV5-A nrPDB 201 8e-52 1FOT-A nrPDB 199 3e-51 3HDN-A nrPDB 198 6e-51 4L42-A nrPDB 197 9e-51 4FR4-A nrPDB 197 9e-51 5N23-A nrPDB 194 8e-50 4RLP-A nrPDB 194 1e-49 4WB7-A nrPDB 191 1e-48 5F9E-A nrPDB 190 1e-48 5X3F-B nrPDB 189 3e-48 3A8W-A nrPDB 187 1e-47 3PFQ-A nrPDB 186 2e-47 2I0E-A nrPDB 186 3e-47 4RA4-A nrPDB 183 2e-46 3TXO-A nrPDB 183 2e-46 4OTD-A nrPDB 176 3e-44 5FET-A nrPDB 172 4e-43 3ORZ-A nrPDB 169 4e-42 5DYK-A nrPDB 167 2e-41 4CRS-A nrPDB 165 6e-41 6E9W-A nrPDB 153 3e-37 3TKU-A nrPDB 152 7e-37 6ED6-A nrPDB 147 2e-35 6BDL-A nrPDB 146 3e-35 2VD5-A nrPDB 145 8e-35 4AW2-A nrPDB 144 1e-34 6BXI-A nrPDB 142 7e-34 5LOH-A nrPDB 134 2e-31 4LQP-A nrPDB 118 1e-26 4D28-A nrPDB 117 2e-26 5YKS-A nrPDB 114 1e-25 2JC6-A nrPDB 114 1e-25 4C0T-A nrPDB 113 2e-25 4YZB-A nrPDB 111 1e-24 4B6L-A nrPDB 111 1e-24 3D2K-A nrPDB 110 3e-24 3MA6-A nrPDB 109 4e-24 4CZT-A nrPDB 109 5e-24 5JN2-A nrPDB 108 7e-24 5FG8-A nrPDB 107 2e-23 3KK8-A nrPDB 107 2e-23 5KZ7-A nrPDB 107 2e-23 2WQN-A nrPDB 107 2e-23 2BDW-A nrPDB 106 4e-23 4B8L-A nrPDB 105 5e-23 5ES1-A nrPDB 105 6e-23 4RGJ-A nrPDB 105 7e-23 2W4O-A nrPDB 105 7e-23 4QMW-A nrPDB 105 8e-23 5IG1-A nrPDB 105 8e-23 4FG9-A nrPDB 105 8e-23 3BHH-A nrPDB 105 8e-23 6C9D-A nrPDB 104 1e-22 2JAM-A nrPDB 104 1e-22 2HAK-A nrPDB 104 1e-22 2VN9-A nrPDB 104 1e-22 3LIJ-A nrPDB 103 2e-22 4JXF-A nrPDB 103 2e-22 2Y7J-A nrPDB 103 2e-22 2VZ6-A nrPDB 102 4e-22 4UZD-A nrPDB 102 4e-22 5U6Y-A nrPDB 102 4e-22 6FDY-U nrPDB 102 5e-22 2V7O-A nrPDB 102 6e-22 6CMJ-A nrPDB 101 9e-22 2QNJ-A nrPDB 101 9e-22 3KN6-A nrPDB 101 1e-21 3NCG-A nrPDB 101 1e-21 5J5T-A nrPDB 101 1e-21 2OU7-A nrPDB 100 3e-21 4J52-A nrPDB 100 3e-21 3DFA-A nrPDB 100 3e-21 3DB8-A nrPDB 99 4e-21 3SOA-A nrPDB 99 5e-21 4CFH-A nrPDB 99 8e-21 3UDB-A nrPDB 99 9e-21 4REW-A nrPDB 98 9e-21 4RED-A nrPDB 98 1e-20 5XZW-A nrPDB 98 1e-20 3Q5I-A nrPDB 98 1e-20 2YCR-A nrPDB 97 2e-20 2XIK-A nrPDB 97 2e-20 4APC-A nrPDB 97 2e-20 4FZF-B nrPDB 97 2e-20 4YNZ-A nrPDB 97 3e-20 5JZN-A nrPDB 97 3e-20 5YV8-A nrPDB 96 4e-20 4NIF-A nrPDB 96 4e-20 3HZT-A nrPDB 96 6e-20 3DXN-A nrPDB 96 6e-20 5WAX-A nrPDB 96 7e-20 3I6U-A nrPDB 96 7e-20 2F57-A nrPDB 94 2e-19 3ZUT-A nrPDB 94 2e-19 6FD3-A nrPDB 94 2e-19 6HXF-B nrPDB 94 2e-19 3UC3-A nrPDB 93 3e-19 4KS7-A nrPDB 93 5e-19 4PDS-A nrPDB 93 5e-19 3DAK-A nrPDB 93 5e-19 4D2V-A nrPDB 92 5e-19 5EZV-A nrPDB 92 6e-19 3H4J-B nrPDB 92 7e-19 4CFF-A nrPDB 92 8e-19 4I6B-A nrPDB 92 9e-19 4AF3-A nrPDB 91 1e-18 4XBR-A nrPDB 91 2e-18 4FIE-A nrPDB 91 2e-18 2Q0N-A nrPDB 91 2e-18 4CQG-A nrPDB 91 2e-18 4JDH-A nrPDB 91 2e-18 5DBX-A nrPDB 90 3e-18 3Q53-A nrPDB 90 3e-18 2YZA-A nrPDB 90 3e-18 6QAU-A nrPDB 89 5e-18 5B2L-A nrPDB 89 6e-18 1UA2-A nrPDB 88 1e-17 2YAB-A nrPDB 88 1e-17 6CCF-A nrPDB 88 1e-17 1PHK-A nrPDB 87 2e-17 4JG6-A nrPDB 87 2e-17 3MN3-A nrPDB 87 2e-17 2UV2-A nrPDB 87 3e-17 5KKR-C nrPDB 86 4e-17 4WNO-A nrPDB 86 7e-17 3EQC-A nrPDB 86 8e-17 3LM0-A nrPDB 85 8e-17 3COM-A nrPDB 85 9e-17 6E2O-A nrPDB 85 1e-16 1KOA-A nrPDB 85 1e-16 2X4F-A nrPDB 85 1e-16 2J90-A nrPDB 84 1e-16 2A27-A nrPDB 84 2e-16 1ZWS-A nrPDB 84 2e-16 3UTO-A nrPDB 84 2e-16 1KOB-A nrPDB 84 2e-16 3IS5-A nrPDB 84 3e-16 4AN9-A nrPDB 83 5e-16 1S9I-A nrPDB 82 6e-16 4UYA-A nrPDB 82 8e-16 3GUB-A nrPDB 82 9e-16 2HW6-A nrPDB 82 1e-15 3F3Z-A nrPDB 81 2e-15 6AO5-A nrPDB 80 2e-15 3NIZ-A nrPDB 80 3e-15 2BPM-A nrPDB 80 3e-15 1G3N-A nrPDB 80 4e-15 3TAC-A nrPDB 80 4e-15 3UIM-A nrPDB 80 4e-15 6GU6-A nrPDB 79 7e-15 4LG4-A nrPDB 79 7e-15 5O2C-A nrPDB 79 9e-15 4X7Q-B nrPDB 79 9e-15 3VN9-A nrPDB 79 9e-15 3ALO-A nrPDB 78 1e-14 4UY9-A nrPDB 78 1e-14 5AIR-A nrPDB 78 1e-14 4MVF-A nrPDB 78 1e-14 4O2Z-A nrPDB 78 1e-14 5O2B-A nrPDB 78 1e-14 3GC9-A nrPDB 78 1e-14 5D7A-A nrPDB 78 1e-14 4BGQ-A nrPDB 78 2e-14 4G3E-A nrPDB 78 2e-14 6O6Q-A nrPDB 77 2e-14 3PPZ-A nrPDB 77 2e-14 4KIK-B nrPDB 77 2e-14 4EQM-A nrPDB 77 2e-14 4YFF-A nrPDB 77 3e-14 4IDT-A nrPDB 77 3e-14 5VD3-A nrPDB 77 3e-14 3FME-A nrPDB 77 4e-14 3QA8-A nrPDB 76 5e-14 4MYG-A nrPDB 76 5e-14 4RC3-A nrPDB 76 5e-14 5TUR-A nrPDB 76 5e-14 4F0G-A nrPDB 76 6e-14 4AU8-A nrPDB 76 6e-14 4KRC-A nrPDB 75 7e-14 6CQF-A nrPDB 75 8e-14 2XNP-A nrPDB 75 8e-14 4QNY-A nrPDB 75 9e-14 3BGP-A nrPDB 75 9e-14 1V0B-A nrPDB 75 1e-13 4PWN-A nrPDB 75 1e-13 4NST-A nrPDB 75 1e-13 4IC8-A nrPDB 74 1e-13 3DTC-A nrPDB 74 1e-13 4U41-A nrPDB 74 1e-13 3ZDU-A nrPDB 74 2e-13 4ZSG-A nrPDB 74 2e-13 6CKI-A nrPDB 74 2e-13 5G6V-A nrPDB 74 2e-13 5EFQ-A nrPDB 74 2e-13 5WNL-A nrPDB 74 3e-13 4AGU-A nrPDB 73 4e-13 2BRG-A nrPDB 73 4e-13 6DTL-A nrPDB 73 5e-13 5TOS-A nrPDB 73 5e-13 1CM8-A nrPDB 73 5e-13 2PMN-X nrPDB 72 7e-13 4BBM-A nrPDB 72 9e-13 3ORP-A nrPDB 72 1e-12 4EWQ-A nrPDB 71 1e-12 5HI2-A nrPDB 71 2e-12 5LPZ-A nrPDB 70 3e-12 6EII-A nrPDB 70 3e-12 5LPV-A nrPDB 70 3e-12 3N9X-A nrPDB 70 3e-12 3FXW-A nrPDB 70 4e-12 2F9G-A nrPDB 70 4e-12 3OMV-A nrPDB 70 4e-12 4MD7-E nrPDB 70 4e-12 4GS6-A nrPDB 69 6e-12 5Z33-A nrPDB 69 8e-12 5XVU-A nrPDB 69 8e-12 5VDK-A nrPDB 69 9e-12 6GVJ-A nrPDB 69 9e-12 3OHT-A nrPDB 68 1e-11 5HIE-A nrPDB 68 1e-11 5ZTN-A nrPDB 68 1e-11 4QTB-A nrPDB 68 1e-11 6J5U-C nrPDB 68 1e-11 3E7O-A nrPDB 68 1e-11 2W96-B nrPDB 68 2e-11 5Y86-A nrPDB 68 2e-11 4Y83-A nrPDB 68 2e-11 6HV0-A nrPDB 67 2e-11 3LLT-A nrPDB 67 2e-11 5NGU-A nrPDB 67 2e-11 6HMD-A nrPDB 67 2e-11 4E7W-A nrPDB 67 3e-11 1ZXE-A nrPDB 67 3e-11 4PL5-B nrPDB 67 3e-11 2QKW-B nrPDB 67 3e-11 5TQX-A nrPDB 67 3e-11 3HMP-A nrPDB 67 3e-11 5AP3-A nrPDB 67 4e-11 4CRL-A nrPDB 66 5e-11 4NEU-A nrPDB 65 7e-11 4OW8-A nrPDB 65 1e-10 5HVK-A nrPDB 65 1e-10 3OZ6-A nrPDB 65 1e-10 4TPT-A nrPDB 65 1e-10 6CTH-A nrPDB 65 1e-10 3NIE-A nrPDB 65 1e-10 3E3P-A nrPDB 64 2e-10 4M66-A nrPDB 64 2e-10 2ZMD-A nrPDB 64 2e-10 2A1A-B nrPDB 64 3e-10 4HVI-A nrPDB 64 3e-10 4X3F-A nrPDB 64 3e-10 2PVN-A nrPDB 63 3e-10 6B2Q-A nrPDB 63 4e-10 5VC6-A nrPDB 63 4e-10 5O0Y-A nrPDB 63 4e-10 3MIA-A nrPDB 63 4e-10 3Q4U-A nrPDB 63 5e-10 3HNG-A nrPDB 63 5e-10 2H34-A nrPDB 62 6e-10 1PY5-A nrPDB 62 7e-10 5X5O-A nrPDB 62 7e-10 2WO6-A nrPDB 62 8e-10 3PG1-A nrPDB 62 8e-10 5UIU-A nrPDB 62 8e-10 4E93-A nrPDB 62 1e-09 2WTK-C nrPDB 61 1e-09 3CJF-A nrPDB 61 2e-09 3DLS-A nrPDB 61 2e-09 5AWM-A nrPDB 61 2e-09 1NY3-A nrPDB 61 2e-09 2OZA-A nrPDB 60 2e-09 3UIU-A nrPDB 60 2e-09 1TKI-A nrPDB 60 3e-09 3KA0-A nrPDB 60 3e-09 2XS0-A nrPDB 60 3e-09 3HKO-A nrPDB 60 3e-09 4JLC-A nrPDB 60 4e-09 3PLS-A nrPDB 60 4e-09 3SOC-A nrPDB 60 4e-09 1JNK-A nrPDB 59 6e-09 3AOX-A nrPDB 59 7e-09 3FI2-A nrPDB 59 7e-09 3MDY-A nrPDB 59 7e-09 4M7I-A nrPDB 59 8e-09 2W1I-A nrPDB 59 9e-09 5VO2-A nrPDB 59 1e-08 3GC0-A nrPDB 58 1e-08 6DC0-A nrPDB 58 1e-08 5XD6-A nrPDB 58 1e-08 5CEK-A nrPDB 58 1e-08 3IO7-A nrPDB 58 1e-08 2I6L-A nrPDB 58 1e-08 4LFI-A nrPDB 58 2e-08 3DKO-A nrPDB 58 2e-08 2JD5-A nrPDB 57 2e-08 6NT9-A nrPDB 57 3e-08 4XLV-A nrPDB 57 3e-08 2GCD-A nrPDB 57 3e-08 3VHK-A nrPDB 57 3e-08 6DBM-A nrPDB 57 4e-08 1U5R-A nrPDB 56 5e-08 4EUT-A nrPDB 56 5e-08 4XUF-A nrPDB 55 8e-08 6O8B-A nrPDB 55 8e-08 5X02-A nrPDB 55 8e-08 4EUU-A nrPDB 55 9e-08 5C26-A nrPDB 55 1e-07 4OLI-A nrPDB 55 1e-07 5AR8-A nrPDB 55 1e-07 4E20-A nrPDB 55 1e-07 3ZZW-A nrPDB 55 1e-07 5CLR-A nrPDB 55 1e-07 2R2P-A nrPDB 54 2e-07 2QLU-A nrPDB 54 2e-07 3RAW-A nrPDB 54 2e-07 3QD2-B nrPDB 54 2e-07 4AT3-A nrPDB 54 2e-07 2BUJ-A nrPDB 54 2e-07 4EBW-A nrPDB 54 2e-07 2Y4I-B nrPDB 54 2e-07 1U59-A nrPDB 54 2e-07 3I81-A nrPDB 54 2e-07 5HLW-A nrPDB 54 3e-07 3ZBF-A nrPDB 54 3e-07 4FL3-A nrPDB 54 3e-07 5GNK-A nrPDB 53 4e-07 4P5Q-A nrPDB 53 4e-07 2J0K-A nrPDB 53 4e-07 5OAT-A nrPDB 53 4e-07 3LZB-A nrPDB 53 4e-07 5H2U-A nrPDB 53 5e-07 1K9A-A nrPDB 52 6e-07 2RIO-A nrPDB 52 7e-07 4LRM-A nrPDB 52 1e-06 5TE0-A nrPDB 52 1e-06 4C59-A nrPDB 52 1e-06 2OZO-A nrPDB 52 1e-06 4IAN-A nrPDB 51 1e-06 3C1X-A nrPDB 51 2e-06 1BYG-A nrPDB 51 2e-06 1JPA-A nrPDB 51 2e-06 3MY0-A nrPDB 51 2e-06 2Y6O-A nrPDB 51 2e-06 4CSV-A nrPDB 51 2e-06 3M42-A nrPDB 51 2e-06 4PDO-A nrPDB 50 2e-06 3TT0-A nrPDB 50 2e-06 3GQL-A nrPDB 50 2e-06 3PP0-A nrPDB 50 2e-06 3RP9-A nrPDB 50 3e-06 4XHH-A nrPDB 50 3e-06 3V5Q-A nrPDB 50 3e-06 5A46-A nrPDB 50 3e-06 6FER-A nrPDB 50 4e-06 5UNP-A nrPDB 50 4e-06 4XCU-A nrPDB 49 5e-06 2WTK-B nrPDB 49 5e-06 3KRL-A nrPDB 49 7e-06 6DBN-A nrPDB 49 7e-06 5GRN-A nrPDB 49 8e-06 3EB0-A nrPDB 49 8e-06 6FEX-A nrPDB 49 9e-06 2PSQ-A nrPDB 48 1e-05 4RT7-A nrPDB 48 1e-05 2C47-A nrPDB 48 1e-05 5L2Q-C nrPDB 48 1e-05 4R7H-A nrPDB 48 1e-05 5E8V-A nrPDB 48 1e-05 5KMM-A nrPDB 48 1e-05 5U6B-A nrPDB 48 2e-05 1FVR-A nrPDB 48 2e-05 5EG3-A nrPDB 48 2e-05 4XHL-A nrPDB 48 2e-05 4K33-A nrPDB 48 2e-05 3A4O-X nrPDB 47 2e-05 4HZS-A nrPDB 47 2e-05 4H1J-A nrPDB 47 2e-05 3KUL-B nrPDB 47 2e-05 3QGY-A nrPDB 47 3e-05 3BEA-A nrPDB 47 3e-05 3SV0-A nrPDB 47 3e-05 4F9B-A nrPDB 47 3e-05 1U54-B nrPDB 47 3e-05 2PL0-A nrPDB 47 4e-05 6EQI-C nrPDB 47 4e-05 6BFN-A nrPDB 46 4e-05 5WNO-A nrPDB 46 4e-05 2OGV-A nrPDB 46 5e-05 2CHL-A nrPDB 46 5e-05 5IKW-A nrPDB 46 7e-05 2PZI-A nrPDB 45 7e-05 3BBT-B nrPDB 45 7e-05 5MJB-A nrPDB 45 7e-05 3G0E-A nrPDB 45 8e-05 2VWV-A nrPDB 45 8e-05 4Y12-A nrPDB 45 8e-05 5M07-A nrPDB 45 9e-05 5U6C-A nrPDB 45 1e-04 6GQK-A nrPDB 45 1e-04 4Y93-A nrPDB 45 1e-04 1LUF-A nrPDB 45 1e-04 2CMW-A nrPDB 44 2e-04 2HK5-A nrPDB 44 2e-04 6E4F-A nrPDB 44 2e-04 6BSD-A nrPDB 44 2e-04 4BTK-A nrPDB 44 2e-04 6NPU-A nrPDB 44 2e-04 4XI2-A nrPDB 44 2e-04 5X8I-B nrPDB 44 3e-04 2DQ7-X nrPDB 44 3e-04 4NFN-A nrPDB 44 3e-04 6FYV-A nrPDB 43 4e-04 6J6I-B nrPDB 43 5e-04 5X18-A nrPDB 43 5e-04 5UU1-A nrPDB 43 5e-04 5AMN-A nrPDB 43 5e-04 6F3F-A nrPDB 43 5e-04 4JRN-A nrPDB 43 6e-04 5SYS-A nrPDB 42 6e-04 5FM2-A nrPDB 42 7e-04 3G2F-A nrPDB 42 7e-04 4XEY-B nrPDB 42 8e-04 3QUP-A nrPDB 42 8e-04 5L6P-A nrPDB 42 9e-04 2H8H-A nrPDB 42 0.001 4NT4-A nrPDB 42 0.001 1AD5-A nrPDB 41 0.001 3SXS-A nrPDB 41 0.002 2XYN-A nrPDB 41 0.002 4TN6-A nrPDB 41 0.002 2X7G-A nrPDB 41 0.002 1DK8-A nrPDB 41 0.002 4WUA-A nrPDB 40 0.003 1EMU-A nrPDB 40 0.003 4BTF-A nrPDB 37 0.025 5FQD-C nrPDB 37 0.029 4M69-B nrPDB 37 0.037 3LMG-A nrPDB 37 0.042 4IX6-A nrPDB 33 0.37 4CI6-B nrPDB 33 0.42 4L68-A nrPDB 33 0.60 4I94-A nrPDB 32 0.64 2RSV-A nrPDB 32 0.66 2LAV-A nrPDB 32 0.68 5DMZ-A nrPDB 32 0.99 1CSN-A nrPDB 31 2.2 2EBZ-A nrPDB 31 2.3 3AB0-B nrPDB 30 4.5 6BII-A nrPDB 30 5.0 4B68-A nrPDB 29 5.5 1I1G-A nrPDB 29 6.5 >3PVW-A nrPDB Length = 695 Score = 1430 bits (3702), Expect = 0.0, Method: Compositional matrix adjust. Identities = 688/689 (99%), Positives = 689/689 (100%) Query: 1 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS 60 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS Sbjct: 1 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS 60 Query: 61 QKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLAC 120 QKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLAC Sbjct: 61 QKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLAC 120 Query: 121 SHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV 180 SHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV Sbjct: 121 SHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV 180 Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER Sbjct: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE Sbjct: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE 360 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE Sbjct: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE 360 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE Sbjct: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA Sbjct: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480 Query: 481 DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK 540 DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK Sbjct: 481 DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK 540 Query: 541 KTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL 600 KTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL Sbjct: 541 KTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL 600 Query: 601 LTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQR 660 LTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQR Sbjct: 601 LTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQR 660 Query: 661 VPKMKNKPRSPVVELSKVPLIQRGSANGL 689 VPKMKNKPR+PVVELSKVPLIQRGSANGL Sbjct: 661 VPKMKNKPRAPVVELSKVPLIQRGSANGL 689 >5UUU-A nrPDB Length = 547 Score = 1066 bits (2756), Expect = 0.0, Method: Compositional matrix adjust. Identities = 511/523 (97%), Positives = 515/523 (98%) Query: 16 AMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKH 75 AME +TPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCL H Sbjct: 25 AMEPGGSTPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNH 84 Query: 76 LEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGH 135 LEEA+PLVEFYEEIKKYEKLETEEER+ SREIFD+YIMKELLACSHPFSKSA EHVQGH Sbjct: 85 LEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGH 144 Query: 136 LVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHR 195 L KKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHR Sbjct: 145 LGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHR 204 Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV Sbjct: 205 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 264 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY Sbjct: 265 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 324 Query: 316 RDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWF 375 RDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWF Sbjct: 325 RDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWF 384 Query: 376 SLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNR 435 SLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNR Sbjct: 385 SLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNR 444 Query: 436 RLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKG 495 RLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKG Sbjct: 445 RLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKG 504 Query: 496 IKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEA 538 IKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEA Sbjct: 505 IKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEA 547 >3NYO-A nrPDB Length = 576 Score = 304 bits (779), Expect = 8e-83, Method: Compositional matrix adjust. Identities = 212/546 (38%), Positives = 302/546 (55%), Gaps = 38/546 (6%) Query: 3 DLEAVLADVSYLMAMEKSKATPAARASK-KILLPEPSIRSV--MQKYLEDRGEVTFEKIF 59 +LE ++A+ L A E ++ K + +L P I ++ LE E+ Sbjct: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCER-- 59 Query: 60 SQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLA 119 Q +G LLFR+FC E ++ V F + + +YE + +++R C R++ ++ Sbjct: 60 -QPIGRLLFREFCATRPELSR-CVAFLDGVAEYE-VTPDDKRKACGRQLTQNFL------ 110 Query: 120 CSHPFSKSAIEHVQGHLVK------KQVP-PDLFQPYIEEICQNLRGDVFQKFIESDKFT 172 SH I V LV +Q P DLFQ + L F +++S F Sbjct: 111 -SHT-GPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFN 168 Query: 173 RFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG 232 RF QWK +E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++G Sbjct: 169 RFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKG 227 Query: 233 ETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLH---YHLSQHGVF 289 E +ALNE+ +L V++ F+V ++YA+ T D L +L LMNGGDL YH+ Q G F Sbjct: 228 EAMALNEKQILEKVNSR---FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-F 283 Query: 290 SEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-H 348 EA FYAAEI GLE +H +VYRDLKP NILLD+HGH+RISDLGLA + + Sbjct: 284 PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK 343 Query: 349 ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTL 407 VGT GYMAPEV+ K Y S DW++LGC+L++++ G SPF+Q K K K E++R+ Sbjct: 344 GRVGTVGYMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK 402 Query: 408 TMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYP 467 + E + FSP+ RSL LL +D RLGC G A+EVKE P F+ L+++ + Sbjct: 403 EVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLE 462 Query: 468 PPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-V 525 PP P + D DI F KG++L +DQ+ Y+ F ++ WQ E+ ET Sbjct: 463 PPFKPDPQAIYCKDVLDIEQFS--TVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETEC 520 Query: 526 FDTINA 531 F +N Sbjct: 521 FQELNV 526 >4TNB-A nrPDB Length = 590 Score = 303 bits (776), Expect = 2e-82, Method: Compositional matrix adjust. Identities = 187/482 (38%), Positives = 273/482 (56%), Gaps = 26/482 (5%) Query: 61 QKLGYLLFRDFCLKHLEEAKP----LVEFYEEIKKYEKLETEEERL-VCSREIFDTYIMK 115 Q +G LLFR FC E +P ++F + + +YE T +E+L ++I Y+ Sbjct: 60 QPIGRLLFRQFC-----ETRPGLECYIQFLDSVAEYEV--TPDEKLGEKGKKIMTKYLTP 112 Query: 116 ELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFC 175 + + + + L++K +LF + + + LRG+ F ++++S F RF Sbjct: 113 KSPVFIAQVGQDLVSQTEEKLLQKPCK-ELFSACAQSVHEYLRGEPFHEYLDSMFFDRFL 171 Query: 176 QWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL 235 QWK +E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE++ Sbjct: 172 QWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESM 230 Query: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEAD 293 ALNE+ +L V++ F+V ++YA+ T D L +L +MNGGDL +H+ G F E Sbjct: 231 ALNEKQILEKVNS---QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEER 287 Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVG 352 FYAAEI+ GLE +H+ VYRDLKP NILLD++GH+RISDLGLA + VG Sbjct: 288 ALFYAAEILCGLEDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVG 347 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAV 411 T GYMAPEVL Y S D++ LGC++++++ G SPFR K K K E+DR L Sbjct: 348 TVGYMAPEVLNNQ-RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEE 406 Query: 412 ELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLI 471 FS E +S+ + LL +D +RLGC A EVK PFFR+++++ + PP + Sbjct: 407 VYSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFV 466 Query: 472 PPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTI 529 P V D DI F KG+ L +D + Y F ++S WQ E+ ET F + Sbjct: 467 PDPRAVYCKDVLDIEQFS--TVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKEL 524 Query: 530 NA 531 N Sbjct: 525 NV 526 >4YHJ-A nrPDB Length = 584 Score = 291 bits (744), Expect = 9e-79, Method: Compositional matrix adjust. Identities = 195/541 (36%), Positives = 294/541 (54%), Gaps = 29/541 (5%) Query: 3 DLEAVLADVSYLMAMEKSKATPAARASKK---ILLPEPSIRSVMQKYLEDRGEVTFEKIF 59 +LE ++A+ L A + + R+ K + LP S S ++ +E +K Sbjct: 2 ELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDK-- 59 Query: 60 SQKLGYLLFRDFCLKHLEEAKPL----VEFYEEIKKYEKLETEEERLVCSREIFDTYIMK 115 Q +G LFR FC + KP +EF + + +YE + +E+R C I D + Sbjct: 60 -QPIGRRLFRQFC-----DTKPTLKRHIEFLDAVAEYE-VADDEDRSDCGLSILDRFFND 112 Query: 116 ELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFC 175 +L A + + L ++ F+ LRG+ F+++ ES F++F Sbjct: 113 KLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFL 172 Query: 176 QWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL 235 QWK +E +T N F +R++G+GGFGEV C+ TGKMYA K L KKRIK ++GE + Sbjct: 173 QWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAM 231 Query: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEAD 293 ALNE+ +L V + F+V ++YA+ T D L +L +MNGGDL +H+ G F E Sbjct: 232 ALNEKRILEKVQSR---FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQR 288 Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASVG 352 FYAAE+ GLE + +VYRDLKP NILLD+ GH+RISDLGLA + + ++ VG Sbjct: 289 AVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVG 348 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAV 411 T GYMAPEV+ Y S DW+ LGC+++++++GHSPF+++K K K E+D+ Sbjct: 349 TVGYMAPEVVNNE-KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTE 407 Query: 412 ELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLI 471 E + FS + +S+ LL ++ ++RLGC G GA VK+ P F+ ++++ + PP Sbjct: 408 EYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFC 467 Query: 472 PPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTI 529 P V D DI F KGI L +D++ Y F +S WQ E+ E+ F I Sbjct: 468 PDPHAVYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDI 525 Query: 530 N 530 N Sbjct: 526 N 526 >3C51-A nrPDB Length = 543 Score = 267 bits (682), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 187/546 (34%), Positives = 293/546 (53%), Gaps = 35/546 (6%) Query: 1 MADLEAVLADVSYLMAMEKSKAT--PAARASK---KILLPEPSIRSVMQKYLEDRGEVTF 55 LE V+A+ +++ A A+ PA+R K ++ LP S +++ L+ + F Sbjct: 3 FGSLETVVANSAFIAARGSFDASSGPASRDRKYLARLKLPPLSKCEALRESLD----LGF 58 Query: 56 EKI-FSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIM 114 E + Q +G LF+ F H E+ P ++ +++I+ Y+ + + R ++ + Y+ Sbjct: 59 EGMCLEQPIGKRLFQQFLRTH-EQHGPALQLWKDIEDYDTAD-DALRPQKAQALRAAYLE 116 Query: 115 KEL-LACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTR 173 + L CS +++ G LFQP + + +L FQ+F++S F R Sbjct: 117 PQAQLFCSFLDAETVARARAG------AGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLR 170 Query: 174 FCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE 233 F QWK +E + + F R++GRGGFGEV+ C+ TGK+YA K L+KKR+K ++G Sbjct: 171 FLQWKWLEAQ-PMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGY 229 Query: 234 TLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL----SQHGVF 289 A+ E+ +L+ V + FIV ++YAF T L ++ +MNGGD+ YH+ + F Sbjct: 230 QGAMVEKKILAKVHS---RFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGF 286 Query: 290 SEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKP 347 E FY A+I+ GLEH+H R ++YRDLKP N+LLD+ G+VRISDLGLA + + K Sbjct: 287 QEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKT 346 Query: 348 HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK-DKHEIDRMT 406 GT G+MAPE+L G YD S D+F+LG L++++ PFR K + E+ + Sbjct: 347 KGYAGTPGFMAPELLL-GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRV 405 Query: 407 LTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKY 466 L AV PD FSP + E LLQ+D +RLG ++ P FR + W+ + Sbjct: 406 LEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGML 465 Query: 467 PPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET- 524 PP +P V A + D+G+F KG+ +D E ++ F T WQ+E+ ET Sbjct: 466 TPPFVPDSRTVYAKNIQDVGAFST--VKGVAFEKADTEFFQEFASGTCPIPWQEEMIETG 523 Query: 525 VFDTIN 530 VF +N Sbjct: 524 VFGDLN 529 >5D9K-A nrPDB Length = 330 Score = 213 bits (543), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 114/301 (37%), Positives = 179/301 (59%), Gaps = 13/301 (4%) Query: 189 NDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 + F + +++G+G FG+V+ +K +D ++YAMK L K +K++ + I++ + Sbjct: 30 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEV 89 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 + PFIV + YAF T KL ILD + GGDL LS+ +F+E D++FY AE+ L L Sbjct: 90 ----NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAL 145 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQ 363 +H+H+ ++YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+ Sbjct: 146 DHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVN 205 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 + + SADW+S G ++F++L G PF + KD+ E M L + +P SPE +S Sbjct: 206 RR-GHTQSADWWSFGVLMFEMLTGTLPF---QGKDRKETMTMILKAKLGMPQFLSPEAQS 261 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 483 LL L +R+ RLG G +E+K FF ++DW ++ ++ PP P G F Sbjct: 262 LLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYF 321 Query: 484 D 484 D Sbjct: 322 D 322 >2Z7Q-A nrPDB Length = 321 Score = 213 bits (541), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 113/299 (37%), Positives = 179/299 (59%), Gaps = 13/299 (4%) Query: 191 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 F + +++G+G FG+V+ RK D+G +YAMK L K +K++ + I+ + Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADV-- 87 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 + PF+V + YAF T KL ILD + GGDL LS+ +F+E D++FY AE+ LGL+H Sbjct: 88 --NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 145 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQKG 365 +H+ ++YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAPEV+ + Sbjct: 146 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQ 205 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 + SADW+S G ++F++L G PF + KD+ E + L + +P S E +SLL Sbjct: 206 -GHSHSADWWSYGVLMFEMLTGSLPF---QGKDRKETMTLILKAKLGMPQFLSTEAQSLL 261 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFD 484 L +R+ RLG GA+E+K F+ ++DW ++ ++ PP P + + FD Sbjct: 262 RALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFD 320 >2JDO-A nrPDB Length = 342 Score = 211 bits (537), Expect = 9e-55, Method: Compositional matrix adjust. Identities = 127/339 (37%), Positives = 191/339 (56%), Gaps = 24/339 (7%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 +TMNDF +++G+G FG+V R+ TG+ YAMK L K+ I K + E +L Sbjct: 7 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ- 65 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 PF+ + YAF T D+L F+++ NGG+L +HLS+ VF+E RFY AEI+ L Sbjct: 66 --NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 123 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA----CDFSKKKPHASVGTHGYMAPEV 361 E++H+R VVYRD+K N++LD+ GH++I+D GL D + K GT Y+APEV Sbjct: 124 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFC--GTPEYLAPEV 181 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 L+ Y + DW+ LG ++++++ G PF +D + + L + P + SPE Sbjct: 182 LEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYN---QDHERLFELILMEEIRFPRTLSPEA 237 Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPP-RGEVN-- 478 +SLL GLL++D +RLG A+EV E FF S++WQ V +K PP P EV+ Sbjct: 238 KSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTR 297 Query: 479 ------AADAFDIGSFDEEDTKGIKLLDS--DQELYRNF 509 A + I D D+ G+ LD +QE++ +F Sbjct: 298 YFDDEFTAQSITITPPDRYDSLGLLELDQREEQEMFEDF 336 >1VZO-A nrPDB Length = 355 Score = 207 bits (527), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 118/310 (38%), Positives = 176/310 (56%), Gaps = 16/310 (5%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGET-LALNERIML 243 + +F + +++G G +G+V+ RK DTGK+YAMK L K I K T ER +L Sbjct: 53 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 112 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 + PF+V + YAF T KL ILD +NGG+L HLSQ F+E +++ Y EI+L Sbjct: 113 EHIR--QSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVL 170 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHGYMAPE 360 LEH+H ++YRD+K NILLD +GHV ++D GL+ +F ++ + GT YMAP+ Sbjct: 171 ALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPD 230 Query: 361 VLQKG-VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFS 418 +++ G +D + DW+SLG ++++LL G SPF K+ EI R L P S Sbjct: 231 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMS 290 Query: 419 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVN 478 + L++ LL +D +RLGC R A E+KE FF+ ++W + +K P P P Sbjct: 291 ALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPV----- 345 Query: 479 AADAFDIGSF 488 D D+ +F Sbjct: 346 IRDELDVSNF 355 >5KCV-A nrPDB Length = 460 Score = 202 bits (515), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 114/311 (36%), Positives = 175/311 (56%), Gaps = 15/311 (4%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 +TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E +L Sbjct: 159 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ- 217 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 PF+ + Y+F T D+L F+++ NGG+L +HLS+ VFSE RFY AEI+ L Sbjct: 218 --NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 275 Query: 306 EHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVL 362 +++H+ + VVYRDLK N++LD+ GH++I+D GL + K GT Y+APEVL Sbjct: 276 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 335 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 + Y + DW+ LG ++++++ G PF +D ++ + L + P + PE + Sbjct: 336 EDN-DYGRAVDWWGLGVVMYEMMCGRLPFY---NQDHEKLFELILMEEIRFPRTLGPEAK 391 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482 SLL GLL++D +RLG A+E+ + FF + WQ V+ +K PP P Sbjct: 392 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP-----QVTSE 446 Query: 483 FDIGSFDEEDT 493 D FDEE T Sbjct: 447 TDTRYFDEEFT 457 >3MV5-A nrPDB Length = 342 Score = 201 bits (511), Expect = 8e-52, Method: Compositional matrix adjust. Identities = 117/327 (35%), Positives = 183/327 (55%), Gaps = 16/327 (4%) Query: 182 LNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 241 ++ +TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E Sbjct: 3 MDPRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 62 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 +L PF+ + Y+F T D+L F+++ NGG+L +HLS+ VFSE RFY AEI Sbjct: 63 VLQ---NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 119 Query: 302 ILGLEHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMA 358 + L+++H+ + VVYRDLK N++LD+ GH++I+D GL + K GT Y+A Sbjct: 120 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 179 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS 418 PEVL+ Y + DW+ LG ++++++ G PF +D ++ + L + P + Sbjct: 180 PEVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYN---QDHEKLFELILMEEIRFPRTLG 235 Query: 419 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVN 478 PE +SLL GLL++D +RLG A+E+ + FF + WQ V+ +K PP P Sbjct: 236 PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP-----Q 290 Query: 479 AADAFDIGSFDEEDT-KGIKLLDSDQE 504 D FDEE T + I + DQ+ Sbjct: 291 VTSETDTRYFDEEFTAQMITITPPDQD 317 >1FOT-A nrPDB Length = 318 Score = 199 bits (506), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 112/325 (34%), Positives = 184/325 (56%), Gaps = 12/325 (3%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK-RIKMKQGETLALNERIMLSL 245 ++ DF + R +G G FG V+ R G+ YAMK L K+ +++KQ E +ER+MLS+ Sbjct: 4 SLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTN-DERLMLSI 62 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 V+ PFI+ M F ++ I+D + GG+L L + F +FYAAE+ L L Sbjct: 63 VT---HPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLAL 119 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKG 365 E++H++ ++YRDLKP NILLD++GH++I+D G A + + GT Y+APEV+ Sbjct: 120 EYLHSKDIIYRDLKPENILLDKNGHIKITDFGFA-KYVPDVTYTLCGTPDYIAPEVVSTK 178 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 Y+ S DW+S G +++++L G++PF T +E L + P F+ +++ LL Sbjct: 179 -PYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYE---KILNAELRFPPFFNEDVKDLL 234 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDI 485 L+ RD+++RLG L G ++VK P+F+ + W+ + + P PP + D Sbjct: 235 SRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQ-GQGDTSQF 293 Query: 486 GSFDEEDTK-GIKLLDSDQELYRNF 509 + EED G++ D +L+R+F Sbjct: 294 DKYPEEDINYGVQGEDPYADLFRDF 318 >3HDN-A nrPDB Length = 373 Score = 198 bits (504), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 120/314 (38%), Positives = 172/314 (54%), Gaps = 14/314 (4%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 N H +DF ++IG+G FG+V R YA+K L KK I K+ E ++ER + Sbjct: 32 NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNV 91 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 L + PF+V + ++F T DKL F+LD +NGG+L YHL + F E RFYAAEI Sbjct: 92 L--LKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 149 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPE 360 L ++H+ +VYRDLKP NILLD GH+ ++D GL + + S GT Y+APE Sbjct: 150 SALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPE 209 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 VL K YD + DW+ LG +L+++L G PF T + ++ L ++L + + Sbjct: 210 VLHKQ-PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYD---NILNKPLQLKPNITNS 265 Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480 R LLEGLLQ+D +RLG E+K FF ++W + +K PP P N + Sbjct: 266 ARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNP-----NVS 319 Query: 481 DAFDIGSFDEEDTK 494 D+ FD E T+ Sbjct: 320 GPNDLRHFDPEFTE 333 >4L42-A nrPDB Length = 346 Score = 197 bits (502), Expect = 9e-51, Method: Compositional matrix adjust. Identities = 121/333 (36%), Positives = 182/333 (54%), Gaps = 26/333 (7%) Query: 191 FSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALN-ERIMLSLV 246 F + R++G+GG+G+V+ RK A+TGK++AMK L K I +T ER +L V Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 79 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 PFIV + YAF T KL IL+ ++GG+L L + G+F E FY AEI + L Sbjct: 80 KH---PFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALG 136 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLQK 364 H+H + ++YRDLKP NI+L+ GHV+++D GL + H GT YMAPE+L + Sbjct: 137 HLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMR 196 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 424 ++ + DW+SLG +++ +L G PF K ID++ L + LP + E R L Sbjct: 197 S-GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKT--IDKI-LKCKLNLPPYLTQEARDL 252 Query: 425 LEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFD 484 L+ LL+R+ RLG A EV+ PFFR ++W+ + +K PP P D Sbjct: 253 LKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPL-----LQSEED 307 Query: 485 IGSFDEEDTKGI--------KLLDSDQELYRNF 509 + FD + T+ L + +QE++R+F Sbjct: 308 VSQFDSKFTRQTPVDSPDDSTLSEEEQEMFRDF 340 >4FR4-A nrPDB Length = 384 Score = 197 bits (502), Expect = 9e-51, Method: Compositional matrix adjust. Identities = 103/306 (33%), Positives = 173/306 (56%), Gaps = 10/306 (3%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 N + + F + R IG+G FG+V +K DT KMYAMK ++K++ + E Sbjct: 9 NEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKE--- 65 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 L ++ + PF+V + Y+F + + ++DL+ GGDL YHL Q+ F E ++ + E++ Sbjct: 66 LQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELV 125 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV-GTHGYMAPEV 361 + L+++ N+ +++RD+KP NILLDEHGHV I+D +A ++ ++ GT YMAPE+ Sbjct: 126 MALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEM 185 Query: 362 L--QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSP 419 +KG Y + DW+SLG ++LLRG P+ + EI T V P ++S Sbjct: 186 FSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQ 245 Query: 420 ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNA 479 E+ SLL+ LL+ + ++R L +V+ P+ ++W VF ++ P IP +G +N Sbjct: 246 EMVSLLKKLLEPNPDQRFSQLS----DVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLNC 301 Query: 480 ADAFDI 485 F++ Sbjct: 302 DPTFEL 307 >5N23-A nrPDB Length = 352 Score = 194 bits (494), Expect = 8e-50, Method: Compositional matrix adjust. Identities = 106/309 (34%), Positives = 174/309 (56%), Gaps = 13/309 (4%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGETLALNERIMLSLV 246 ++ F R +G G FG V + +TG YAMK LDK+++ K+KQ E LNE+ + V Sbjct: 41 LDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEH-TLNEKRIQQAV 99 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + PF+V + ++F L +L+ GG++ HL + G FSE RFYAA+I+L E Sbjct: 100 ---NFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE-VLQKG 365 ++H+ ++YRDLKP N+L+D+ G+++++D G A + P GT Y+APE +L KG Sbjct: 157 YLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTLCGTPEYLAPEIILSKG 216 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 Y+ + DW++LG +++++ G+ PF + +E ++ V P FS +L+ LL Sbjct: 217 --YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYE---KIVSGKVRFPSHFSSDLKDLL 271 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDI 485 LLQ D+ +R G L G ++K +F + DW ++ +K P IP FD Sbjct: 272 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD- 330 Query: 486 GSFDEEDTK 494 ++EE+ + Sbjct: 331 -DYEEEEIR 338 >4RLP-A nrPDB Length = 288 Score = 194 bits (492), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 112/288 (38%), Positives = 165/288 (57%), Gaps = 13/288 (4%) Query: 191 FSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALN-ERIMLSLV 246 F + R++G+GG+G+V+ RK A+TGK++AMK L K I +T ER +L V Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 66 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 PFIV + YAF T KL IL+ ++GG+L L + G+F E FY AEI + L Sbjct: 67 KH---PFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALG 123 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLQK 364 H+H + ++YRDLKP NI+L+ GHV+++D GL + H GT YMAPE+L + Sbjct: 124 HLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMR 183 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 424 ++ + DW+SLG +++ +L G PF K ID++ L + LP + E R L Sbjct: 184 S-GHNRAVDWWSLGALMYDMLTGAPPFTGENRKK--TIDKI-LKCKLNLPPYLTQEARDL 239 Query: 425 LEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 472 L+ LL+R+ RLG A EV+ PFFR ++W+ + +K PP P Sbjct: 240 LKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >4WB7-A nrPDB Length = 405 Score = 191 bits (484), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 110/338 (32%), Positives = 188/338 (55%), Gaps = 15/338 (4%) Query: 159 GDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYA 218 G+ ++F+ K +W++ N ++ F + +G G FG V + +TG YA Sbjct: 67 GEEVKEFLAKAKEDFLKKWESPAQNT-AHLDQFERIKTLGTGSFGRVMLVKHKETGNHYA 125 Query: 219 MKCLDKKRI-KMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGG 277 MK LDK+++ K+KQ E LNE+ +L V + PF+V + ++F L +++ + GG Sbjct: 126 MKILDKQKVVKLKQIEH-TLNEKRILQAV---NFPFLVKLEFSFKDNSNLYMVMEYVPGG 181 Query: 278 DLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLG 337 ++ HL + G FSE RFYAA+I+L E++H+ ++YRDLKP N+L+D+ G+++++D G Sbjct: 182 EMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFG 241 Query: 338 LACDFSKKKPHASVGTHGYMAPE-VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKT 396 A K + GT Y+APE +L KG Y+ + DW++LG +++++ G+ PF + Sbjct: 242 FAKRV-KGRTWTLCGTPEYLAPEIILSKG--YNKAVDWWALGVLIYEMAAGYPPFFADQP 298 Query: 397 KDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 +E ++ V P FS +L+ LL LLQ D+ +R G L G ++K +F + Sbjct: 299 IQIYE---KIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 355 Query: 457 DWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 494 DW ++ +K P IP FD ++EE+ + Sbjct: 356 DWIAIYQRKVEAPFIPKFKGPGDTSNFD--DYEEEEIR 391 >5F9E-A nrPDB Length = 353 Score = 190 bits (483), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 117/344 (34%), Positives = 184/344 (53%), Gaps = 36/344 (10%) Query: 182 LNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 241 L I L + DF +H+++G+G FG+V+ T + +A+K L K + M + E+ Sbjct: 12 LQIKLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKR 71 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 +LSL + PF+ M F T + L F+++ +NGGDL YH+ F + FYAAEI Sbjct: 72 VLSL--AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEI 129 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAP 359 ILGL+ +H++ +VYRDLK NILLD+ GH++I+D G+ + K + GT Y+AP Sbjct: 130 ILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAP 189 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSP 419 E+L G Y+ S DW+S G +L+++L G SPF H D L ++ + + F P Sbjct: 190 EILL-GQKYNHSVDWWSFGVLLYEMLIGQSPF--------HGQDEEELFHSIRMDNPFYP 240 Query: 420 -----ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPR 474 E + LL L R+ +RLG G ++++ P FR ++W+ + ++ PP P Sbjct: 241 RWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRP-- 294 Query: 475 GEVNAADAFDIGSFDEE--------DTKGIKLLDS-DQELYRNF 509 FD +FD+E L++S DQ ++RNF Sbjct: 295 ---KVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNF 335 >5X3F-B nrPDB Length = 393 Score = 189 bits (481), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 109/334 (32%), Positives = 184/334 (55%), Gaps = 15/334 (4%) Query: 163 QKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL 222 Q F+ K +W+ N ++ F + +G G FG V + ++G YAMK L Sbjct: 59 QAFLAKAKEDFLKKWETPSQNT-AQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKIL 117 Query: 223 DKKRI-KMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHY 281 DK+++ K+KQ E LNE+ +L V + PF+V + ++F L +++ + GG++ Sbjct: 118 DKQKVVKLKQIEH-TLNEKRILQAV---NFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFS 173 Query: 282 HLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD 341 HL + G FSE RFYAA+I+L E++H+ ++YRDLKP N+L+D+ G+++++D G A Sbjct: 174 HLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 233 Query: 342 FSKKKPHASVGTHGYMAPE-VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH 400 K + GT Y+APE +L KG Y+ + DW++LG +++++ G+ PF + + Sbjct: 234 V-KGRTWTLCGTPEYLAPEIILSKG--YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIY 290 Query: 401 EIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQM 460 E ++ V P FS +L+ LL LLQ D+ +R G L G ++K +F + DW Sbjct: 291 E---KIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIA 347 Query: 461 VFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 494 ++ +K P IP FD ++EE+ + Sbjct: 348 IYQRKVEAPFIPKFKGPGDTSNFD--DYEEEEIR 379 >3A8W-A nrPDB Length = 345 Score = 187 bits (476), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 107/332 (32%), Positives = 183/332 (55%), Gaps = 18/332 (5%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 L + DF + R+IGRG + +V R T ++YAMK + K+ + + E+ + Sbjct: 6 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ 65 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 S + PF+V + F T +L F+++ +NGGDL +H+ + E RFY+AEI L L Sbjct: 66 AS--NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLAL 123 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVLQ 363 ++H R ++YRDLK N+LLD GH++++D G+ + + S GT Y+APE+L Sbjct: 124 NYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEIL- 182 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEID------RMTLTMAVELPDSF 417 +G Y S DW++LG ++F+++ G SPF + D + + ++ L + +P S Sbjct: 183 RGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSL 242 Query: 418 SPELRSLLEGLLQRDVNRRLGCLGR-GAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGE 476 S + S+L+ L +D RLGC + G +++ PFFR++DW M+ ++ PP P Sbjct: 243 SVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKP---- 298 Query: 477 VNAADAFDIGSFDEEDT-KGIKLLDSDQELYR 507 N + F + +FD + T + ++L D ++ R Sbjct: 299 -NISGEFGLDNFDSQFTNEPVQLTPDDDDIVR 329 >3PFQ-A nrPDB Length = 674 Score = 186 bits (473), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 107/326 (32%), Positives = 179/326 (54%), Gaps = 15/326 (4%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 + + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+L Sbjct: 338 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 397 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 G PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAEI +GL Sbjct: 398 --PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 455 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLQ 363 + ++ ++YRDLK N++LD GH++I+D G+ + + GT Y+APE++ Sbjct: 456 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 515 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 Y S DW++ G +L+++L G +PF + +D+ E+ + + V P S S E + Sbjct: 516 Y-QPYGKSVDWWAFGVLLYEMLAGQAPF---EGEDEDELFQSIMEHNVAYPKSMSKEAVA 571 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 483 + +GL+ + +RLGC G +++KE FFR +DW+ + ++ PP P NA + Sbjct: 572 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKASGRNAEN-- 629 Query: 484 DIGSFDEEDTKGIKLLD-SDQELYRN 508 FD T+ +L DQE+ RN Sbjct: 630 ----FDRFFTRHPPVLTPPDQEVIRN 651 >2I0E-A nrPDB Length = 353 Score = 186 bits (472), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 107/326 (32%), Positives = 179/326 (54%), Gaps = 15/326 (4%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 + + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+L Sbjct: 17 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 76 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 G PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAEI +GL Sbjct: 77 --PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 134 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLQ 363 + ++ ++YRDLK N++LD GH++I+D G+ + + GT Y+APE++ Sbjct: 135 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 194 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 Y S DW++ G +L+++L G +PF + +D+ E+ + + V P S S E + Sbjct: 195 YQ-PYGKSVDWWAFGVLLYEMLAGQAPF---EGEDEDELFQSIMEHNVAYPKSMSKEAVA 250 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 483 + +GL+ + +RLGC G +++KE FFR +DW+ + ++ PP P NA + Sbjct: 251 ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAEN-- 308 Query: 484 DIGSFDEEDTKGIKLLD-SDQELYRN 508 FD T+ +L DQE+ RN Sbjct: 309 ----FDRFFTRHPPVLTPPDQEVIRN 330 >4RA4-A nrPDB Length = 355 Score = 183 bits (465), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 101/301 (33%), Positives = 166/301 (55%), Gaps = 9/301 (2%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 + + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+L Sbjct: 17 VKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLAL 76 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 + PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAEI +GL Sbjct: 77 LDKP--PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGL 134 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLQ 363 +H R ++YRDLK N++LD GH++I+D G+ + GT Y+APE++ Sbjct: 135 FFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA 194 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 Y S DW++ G +L+++L G PF +D+ E+ + + V P S S E S Sbjct: 195 YQ-PYGKSVDWWAYGVLLYEMLAGQPPF---DGEDEDELFQSIMEHNVSYPKSLSKEAVS 250 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 483 + +GL+ + +RLGC G ++V+E FFR +DW+ + ++ PP P+ A+ F Sbjct: 251 ICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPF-KPKVSGKGAENF 309 Query: 484 D 484 D Sbjct: 310 D 310 >3TXO-A nrPDB Length = 353 Score = 183 bits (465), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 108/335 (32%), Positives = 176/335 (52%), Gaps = 21/335 (6%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 L +++F R++G+G FG+V R +TG +YA+K L K I + E+ +LSL Sbjct: 20 LGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSL 79 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 + PF+ + F TPD+L F+++ +NGGDL +H+ + F EA RFYAAEII L Sbjct: 80 AR--NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 137 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA----CDFSKKKPHASVGTHGYMAPEV 361 +H++ ++YRDLK N+LLD GH +++D G+ C+ GT Y+APE+ Sbjct: 138 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTA--TFCGTPDYIAPEI 195 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 LQ+ + Y + DW+++G +L+++L GH+PF D E L V P + Sbjct: 196 LQE-MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFE---AILNDEVVYPTWLHEDA 251 Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQE-VKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480 +L+ + ++ RLG L +G + + PFF+ +DW + ++ PP P Sbjct: 252 TGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDV 311 Query: 481 DAFDIGSFDEE------DTKGIKLLDSDQELYRNF 509 FD EE D + +++ D+ +RNF Sbjct: 312 SNFDPDFIKEEPVLTPIDEGHLPMINQDE--FRNF 344 >4OTD-A nrPDB Length = 341 Score = 176 bits (446), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 118/334 (35%), Positives = 185/334 (55%), Gaps = 17/334 (5%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK-QGETLALNERIMLS 244 LT+ DF ++GRG FG+V +G+++A+K L K I + + E+L +RI+ + Sbjct: 9 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 68 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 + S G PF+V + F TP+ + F+++ GGDL H+ VFSE FY+A ++LG Sbjct: 69 VTSAGH-PFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHI-HSDVFSEPRAIFYSACVVLG 126 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEVL 362 L+ +H +VYRDLK N+LLD G+V+I+D GL + S GT ++APEVL Sbjct: 127 LQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 186 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 +Y + DW+ LG +L+++L G SPF D+ E+ + V P S E Sbjct: 187 TD-TSYTRAVDWWGLGVLLYEMLVGESPF---PGDDEEEVFDSIVNDEVRYPRFLSAEAI 242 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482 ++ LL+R+ RRLG R A++VK+ PFFR+L W+ + ++ PPP +P + Sbjct: 243 GIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP-----TLSGR 297 Query: 483 FDIGSFDEEDTKGIKLLDSDQELYRNFPLTISER 516 D+ +FDEE T L ++ PLT +E+ Sbjct: 298 TDVSNFDEEFTGEAPTLSPPRDAR---PLTAAEQ 328 >5FET-A nrPDB Length = 847 Score = 172 bits (436), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 109/308 (35%), Positives = 167/308 (54%), Gaps = 11/308 (3%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGETLALNERIMLSLV 246 M++ RIIGRG FG V T YA+KC+ K+ I + Q + L I Sbjct: 532 MHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREI----T 587 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + D PFI+ + F + F+ +L+ GG+L+ + + G+ S+ +FY IIL +E Sbjct: 588 AENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIE 647 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGV 366 ++H R +VYRDLKP NILLD+ G+V++ D G A + + + VGT YMAPEV+ G Sbjct: 648 YLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKI-QGRAYTLVGTPHYMAPEVIL-GK 705 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR-SLL 425 Y + D ++LG L++ + G PF + +D+ EI R LT + PD S + +L+ Sbjct: 706 GYGCTVDIWALGVCLYEFICGPLPFGNDQ-EDQLEIFRDILTGQLTFPDYVSDQDSINLM 764 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDI 485 + LL R R+GC G +++KE FF + +W + + PPL+ +GE A D DI Sbjct: 765 KRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLV-SKGETYAED-IDI 822 Query: 486 GSFDEEDT 493 +EED Sbjct: 823 KQIEEEDA 830 >3ORZ-A nrPDB Length = 316 Score = 169 bits (427), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 101/286 (35%), Positives = 160/286 (55%), Gaps = 13/286 (4%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 DF +I+G G F V R+ T + YA+K L+K+ I + ER ++S + Sbjct: 38 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL--- 94 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 D PF V + + F +KL F L G+L ++ + G F E RFY AEI+ LE++H Sbjct: 95 DHPFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLH 154 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFS----KKKPHASVGTHGYMAPEVLQKG 365 + +++RDLKP NILL+E H++I+D G A S + + ++ VGT Y++PE+L + Sbjct: 155 GKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEK 214 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 A SS W +LGC++++L+ G PFR +++ I + + + + P+ F P+ R L+ Sbjct: 215 SACKSSDLW-ALGCIIYQLVAGLPPFR---AGNEYLIFQKIIKLEYDFPEKFFPKARDLV 270 Query: 426 EGLLQRDVNRRLGCLG-RGAQEVKESPFFRSLDWQMVFLQKYPPPL 470 E LL D +RLGC G +K PFF S+ W+ + Q+ PP L Sbjct: 271 EKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLH-QQTPPKL 315 >5DYK-A nrPDB Length = 853 Score = 167 bits (423), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 102/296 (34%), Positives = 161/296 (54%), Gaps = 10/296 (3%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGETLALNERIMLSLV 246 M++ RIIGRG FG V T YA+KC+ K+ I + Q + L I Sbjct: 538 MDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREI----T 593 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + D PFI+ + F F+ +L+ GG+L+ + + G+ S++ +FY IIL +E Sbjct: 594 AENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIE 653 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGV 366 ++H R +VYRDLKP NILLD+ G+V++ D G A + + + VGT YMAPEV+ G Sbjct: 654 YLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKV-QGRAYTLVGTPHYMAPEVIL-GK 711 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS-PELRSLL 425 Y + D ++LG L++ + G PF + +D+ EI R LT + PD + + +L+ Sbjct: 712 GYGCTVDIWALGICLYEFICGPLPFGNDE-EDQLEIFRDILTGQLTFPDYVTDTDSINLM 770 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAAD 481 + LL R R+GC G +++K+ PFF + +W + + PPL+ + E A D Sbjct: 771 KRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLV-SKSETYAED 825 >4CRS-A nrPDB Length = 341 Score = 165 bits (418), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 113/339 (33%), Positives = 179/339 (52%), Gaps = 24/339 (7%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + DF ++ RG FG+V +T +M+A+K L K I + + E+ + Sbjct: 7 FQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIF 66 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 V++ PF+V + F T + + F+++ GGDL H+ VFSE FYAA ++L Sbjct: 67 ETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAVFYAACVVL 125 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV--GTHGYMAPEV 361 GL+++H +VYRDLK N+LLD G V+I+D GL + S GT ++APEV Sbjct: 126 GLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 185 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 L + +Y + DW+ LG +++++L G SPF D+ E+ + V P S E Sbjct: 186 LTE-TSYTRAVDWWGLGVLIYEMLVGESPF---PGDDEEEVFDSIVNDEVRYPRFLSTEA 241 Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPP-RGEVNAA 480 S++ LL+R+ RRLG + A++VK+ PFFR +DW + +K PP IP RG Sbjct: 242 ISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGRE--- 298 Query: 481 DAFDIGSFDEEDTKGIKLL----------DSDQELYRNF 509 D+ +FD+E T +L + +QE++R+F Sbjct: 299 ---DVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDF 334 >6E9W-A nrPDB Length = 443 Score = 153 bits (386), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 111/368 (30%), Positives = 185/368 (50%), Gaps = 23/368 (6%) Query: 138 KKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKF-TRFCQWKNVELNIHLTMNDFSVHRI 196 K +V D ++ + +L +K D F +R+ N ++ + D+ V ++ Sbjct: 50 KSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKV 109 Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IGRG FGEV R T K+YAMK L K + + ER +++ ++ P++V Sbjct: 110 IGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS---PWVVQ 166 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + YAF L +++ M GGDL +S + V E RFY AE++L L+ +H+ ++R Sbjct: 167 LFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWARFYTAEVVLALDAIHSMGFIHR 225 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKK---KPHASVGTHGYMAPEVL--QKGVA-YDS 370 D+KP N+LLD+ GH++++D G +K+ + +VGT Y++PEVL Q G Y Sbjct: 226 DVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGR 285 Query: 371 SADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPD--SFSPELRSLLEGL 428 DW+S+G L+++L G +PF + M ++ PD S E ++L+ Sbjct: 286 ECDWWSVGVFLYEMLVGDTPFYADSLVGTYS-KIMNHKNSLTFPDDNDISKEAKNLICAF 344 Query: 429 LQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSF 488 L D RLG G +E+K FF++ W L+ P++P + + D +F Sbjct: 345 LT-DREVRLG--RNGVEEIKRHLFFKNDQWAWETLRDTVAPVVP-----DLSSDIDTSNF 396 Query: 489 DE-EDTKG 495 D+ E+ KG Sbjct: 397 DDLEEDKG 404 >3TKU-A nrPDB Length = 433 Score = 152 bits (383), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 100/312 (32%), Positives = 163/312 (52%), Gaps = 18/312 (5%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + L DF + ++IGRG FGEV + +T ++YAMK L+K + +K+ ET E Sbjct: 85 MQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEM-LKRAETACFREE--R 141 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADM-RFYAAEII 302 ++ GDC +I + YAF + L ++D GGDL LS+ DM RFY E++ Sbjct: 142 DVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMV 201 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC----DFSKKKPHASVGTHGYMA 358 L ++ +H V+RD+KP N+LLD +GH+R++D G +C D + +VGT Y++ Sbjct: 202 LAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFG-SCLKMNDDGTVQSSVAVGTPDYIS 260 Query: 359 PEVLQK---GVA-YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP 414 PE+LQ G+ Y DW+SLG ++++L G +PF + + M + P Sbjct: 261 PEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYG-KIMNHEERFQFP 319 Query: 415 DSFSPELRSLLEGLLQRDVNRRLGCLGR-GAQEVKESPFFRSLDWQMVFLQKYPPPLIPP 473 S ++ + L+QR + R LG+ G ++ K+ FF L+W+ + + P IP Sbjct: 320 -SHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENI--RNLEAPYIPD 376 Query: 474 RGEVNAADAFDI 485 + FD+ Sbjct: 377 VSSPSDTSNFDV 388 >6ED6-A nrPDB Length = 415 Score = 147 bits (370), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 98/320 (30%), Positives = 165/320 (51%), Gaps = 20/320 (6%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + + D+ V ++IGRG FGEV R + K+YAMK L K + + ER ++ Sbjct: 83 LQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIM 142 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 + ++ P++V + YAF L +++ M GGDL +S + V E +FY AE++L Sbjct: 143 AFANS---PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWAKFYTAEVVL 198 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHASVGTHGYMAPE 360 L+ +H+ +++RD+KP N+LLD+HGH++++D G + +VGT Y++PE Sbjct: 199 ALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPE 258 Query: 361 VL--QKGVA-YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS- 416 VL Q G Y DW+S+G L+++L G +PF + M ++ P+ Sbjct: 259 VLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYS-KIMDHKNSLCFPEDA 317 Query: 417 -FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRG 475 S ++L+ L D RLG G +E+++ PFF++ W +++ P++P Sbjct: 318 EISKHAKNLICAFLT-DREVRLG--RNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELS 374 Query: 476 EVNAADAFDIGSFDEEDTKG 495 + FD D ED KG Sbjct: 375 SDIDSSNFD----DIEDDKG 390 >6BDL-A nrPDB Length = 347 Score = 146 bits (368), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 96/312 (30%), Positives = 162/312 (51%), Gaps = 13/312 (4%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRI-KMKQGETLALNERIM 242 +L ++DF++ +G GGFG V + K++ K +AMK L K+ I +Q E + ++IM Sbjct: 30 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM 89 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 S FIV + F L +++ GG+L L G F ++ RFY A ++ Sbjct: 90 QGAHSD----FIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVV 145 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 361 ++H++ ++YRDLKP N++LD G+ ++ D G A KK GT Y+APE+ Sbjct: 146 EAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 205 Query: 362 -LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 L KG +D SAD++SLG ++++LL G PF + I + M +E P + Sbjct: 206 ILNKG--HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM-IEFPKKIAKN 262 Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480 +L++ L + + + RLG L G +++++ +F +W+ + PP+IP Sbjct: 263 AANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDT 322 Query: 481 DAFDIGSFDEED 492 FD SF E++ Sbjct: 323 SNFD--SFPEDN 332 >2VD5-A nrPDB Length = 412 Score = 145 bits (365), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 109/330 (33%), Positives = 167/330 (50%), Gaps = 37/330 (11%) Query: 166 IESDKFTR-FCQWKN---VELN-IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMK 220 + DK+ F QW V L + L +DF + ++IGRG F EV + TG++YAMK Sbjct: 33 LAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMK 92 Query: 221 CLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLH 280 ++K + +K+GE E ++ GD +I + +AF + L +++ GGDL Sbjct: 93 IMNKWDM-LKRGEVSCFREE--RDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLL 149 Query: 281 YHLSQHGVFSEADM-RFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLG-- 337 LS+ G A+M RFY AEI++ ++ +H V+RD+KP NILLD GH+R++D G Sbjct: 150 TLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSC 209 Query: 338 --LACDFSKKKPHASVGTHGYMAPEVLQK------GVAYDSSADWFSLGCMLFKLLRGHS 389 L D + +VGT Y++PE+LQ +Y DW++LG +++ G + Sbjct: 210 LKLRAD-GTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQT 268 Query: 390 PFRQHKTKDKH-EIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGC-----LGR- 442 PF T + + +I +++ L D PE RD +RL C LGR Sbjct: 269 PFYADSTAETYGKIVHYKEHLSLPLVDEGVPE--------EARDFIQRLLCPPETRLGRG 320 Query: 443 GAQEVKESPFFRSLDWQMVFLQKYPPPLIP 472 GA + + PFF LDW L+ PP P Sbjct: 321 GAGDFRTHPFFFGLDWDG--LRDSVPPFTP 348 >4AW2-A nrPDB Length = 437 Score = 144 bits (364), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 98/317 (30%), Positives = 159/317 (50%), Gaps = 28/317 (8%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + L DF + ++IGRG FGEV + + K++AMK L+K + +K+ ET E Sbjct: 69 MRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEM-LKRAETACFREE--R 125 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ-HGVFSEADMRFYAAEII 302 ++ GD +I + YAF + L ++D GGDL LS+ E RFY AE++ Sbjct: 126 DVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMV 185 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHASVGTHGYMAP 359 + ++ +H V+RD+KP NIL+D +GH+R++D G + + +VGT Y++P Sbjct: 186 IAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISP 245 Query: 360 EVLQ-----KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP 414 E+LQ KG Y DW+SLG ++++L G +PF ++ M + Sbjct: 246 EILQAMEGGKG-RYGPECDWWSLGVCMYEMLYGETPFYAESL-----VETYGKIMNHKER 299 Query: 415 DSFSPELRSLLEGLLQRDVNRRLGC-----LGR-GAQEVKESPFFRSLDWQMVFLQKYPP 468 F ++ + E +D+ RRL C LG+ G ++ K+ PFF +DW + + Sbjct: 300 FQFPTQVTDVSEN--AKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNI--RNCEA 355 Query: 469 PLIPPRGEVNAADAFDI 485 P IP FD+ Sbjct: 356 PYIPEVSSPTDTSNFDV 372 >6BXI-A nrPDB Length = 333 Score = 142 bits (357), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 106/345 (30%), Positives = 167/345 (48%), Gaps = 56/345 (16%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 L + DF ++IGRG FGEV +K DTG +YAMK L K + K+ ER + Sbjct: 3 LGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAER---DI 59 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 + D ++V M Y+F L I++ + GGD+ L + +E + +FY AE +L + Sbjct: 60 LVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAI 119 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC--------------------DF--- 342 + +H ++RD+KP N+LLD GHV++SD GL DF Sbjct: 120 DSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ 179 Query: 343 ---SKKKPH-----------ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGH 388 SK+K ++VGT Y+APEV + Y+ DW+SLG +++++L G+ Sbjct: 180 NMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQ-TGYNKLCDWWSLGVIMYEMLIGY 238 Query: 389 SPF---RQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQ 445 PF +T K + TLT E+P S + + L+ + R+G G + Sbjct: 239 PPFCSETPQETYKKVMNWKETLTFPPEVP--ISEKAKDLILRFCC-EWEHRIG--APGVE 293 Query: 446 EVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDE 490 E+K + FF +DW+ + + P I E+ + D D +FDE Sbjct: 294 EIKSNSFFEGVDWEHI---RERPAAISI--EIKSID--DTSNFDE 331 >5LOH-A nrPDB Length = 341 Score = 134 bits (336), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 90/297 (30%), Positives = 152/297 (51%), Gaps = 27/297 (9%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 ++ +FS+ + I RG FG+VY +K GK+YA+K + K + K ER L+L Sbjct: 34 SIEEFSIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALS 91 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + PFIV + Y+ + + + +++ + GGD+ L +G F E Y +E+ L L+ Sbjct: 92 KS---PFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALD 148 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLA-CDFSKKKPHASV-------GTHGYMA 358 ++H +++RDLKP N+L+ GH++++D GL+ ++ + GT Y+A Sbjct: 149 YLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLA 208 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS-- 416 PE+L G A+ + DW++LG LF+ L G PF + ++ + L + P+ Sbjct: 209 PELLL-GRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQ---QVFQNILKRDIPWPEGEE 264 Query: 417 -FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 472 S +S +E LL D +R G +E+K P F +DW+ LQ P IP Sbjct: 265 KLSDNAQSAVEILLTIDDTKRAGM-----KELKRHPLFSDVDWEN--LQHQTMPFIP 314 >4LQP-A nrPDB Length = 508 Score = 118 bits (295), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 62/155 (40%), Positives = 90/155 (58%), Gaps = 3/155 (1%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 DF ++IG+G FGEV +K DTGK+YAMK L K + K ER +L+ Sbjct: 103 DFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLA---GS 159 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 D P++V + Y+F L I++ + GGDL L + +F+E RFY AE IL +E +H Sbjct: 160 DSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIH 219 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK 344 ++R +KP NIL+D GH+++SD GL+ F K Sbjct: 220 KLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHK 254 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 44/128 (34%), Positives = 68/128 (53%), Gaps = 10/128 (7%) Query: 348 HASVGTHGYMAPEV-LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMT 406 +++VGT Y+APE+ L +G Y DW+SLG ++++ L G PF ++ + M Sbjct: 321 YSTVGTPDYIAPEIFLYQG--YGQECDWWSLGAIMYECLIGWPPFCSETPQETYR-KIMN 377 Query: 407 LTMAVELPDSF--SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQ 464 ++ PD S E L+ LL ++RLG G GA E+K PFFR +DW + + Sbjct: 378 FEQTLQFPDDIHISYEAEDLIRRLLTH-ADQRLGRHG-GADEIKSHPFFRGVDWNTI--R 433 Query: 465 KYPPPLIP 472 + P IP Sbjct: 434 QVEAPYIP 441 >4D28-A nrPDB Length = 446 Score = 117 bits (292), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 83/267 (31%), Positives = 135/267 (50%), Gaps = 15/267 (5%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + V R IG G F +V R DTG A+K + K I +K + I S++ Sbjct: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTI-LKNRMVDQIKREI--SIMKIVR 67 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P IV + + K+ +L+ + GG+L + G E + R Y +++ + H H+ Sbjct: 68 HPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHS 127 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLAC--DFSKKKPHASVGTHGYMAPEVLQKGVAY 368 + V +RDLKP N+LLD +G++++SD GL+ + + + GT Y+APEVL G Y Sbjct: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLS-GQGY 186 Query: 369 D-SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEG 427 D S+AD +S G +LF +L G+ PF + D + R + P FS E++ L+ Sbjct: 187 DGSAADIWSCGVILFVILAGYLPFSE---TDLPGLYRKINAAEFDCPPWFSAEVKFLIHR 243 Query: 428 LLQRDVNRRLGCLGRGAQEVKESPFFR 454 +L + R+ G +K+ P+FR Sbjct: 244 ILDPNPKTRIQIQG-----IKKDPWFR 265 >5YKS-A nrPDB Length = 377 Score = 114 bits (286), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 93/289 (32%), Positives = 145/289 (50%), Gaps = 27/289 (9%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + + +GRG F V R TG+ A+K +DK ++ L R M LV Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCM-KLVQH-- 93 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADM-RFYAAEIILGLEHMH 309 P IV + T KL IL+L +GGD+ ++ +H D+ + Y A+I+ + + H Sbjct: 94 -PNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCH 152 Query: 310 NRFVVYRDLKPANILL-DEHGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQKGVA 367 VV+RDLKP N++ ++ G V+++D G + F KK S G+ Y APE+L G Sbjct: 153 KLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILL-GDE 211 Query: 368 YDSSA-DWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE----LPDSFSPELR 422 YD+ A D +SLG +LF L+ G PF++ D TLTM ++ +P S E + Sbjct: 212 YDAPAVDIWSLGVILFMLVCGQPPFQEAN-------DSETLTMIMDCKYTVPSHVSKECK 264 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLI 471 L+ +LQRD RR +E++ P+ + +D KY PL+ Sbjct: 265 DLITRMLQRDPKRRASL-----EEIENHPWLQGVDPSPA--TKYNIPLV 306 >2JC6-A nrPDB Length = 334 Score = 114 bits (285), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 75/254 (29%), Positives = 131/254 (51%), Gaps = 11/254 (4%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F +G G F EV + TGK++A+KC+ KK +K K E+ NE +L + + Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK--ESSIENEIAVLRKIKHEN 81 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 IV + + +P+ L ++ L++GG+L + + G ++E D +++ + ++H Sbjct: 82 ---IVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHR 138 Query: 311 RFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKKPHASV-GTHGYMAPEVLQKGV 366 +V+RDLKP N+L DE + ISD GL+ K ++ GT GY+APEVL + Sbjct: 139 MGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQK- 197 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPF-RQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 Y + D +S+G + + LL G+ PF ++ +K +I + D S + + Sbjct: 198 PYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFI 257 Query: 426 EGLLQRDVNRRLGC 439 L+++D N+R C Sbjct: 258 RNLMEKDPNKRYTC 271 >4C0T-A nrPDB Length = 974 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 83/305 (27%), Positives = 153/305 (50%), Gaps = 29/305 (9%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALN-ERIM 242 I + DF + +G G + V TGK YA+K LDK+ I +K+ + +N E+ Sbjct: 261 IRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHI-IKEKKVKYVNIEKHA 319 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 L+ +S + ++ + + F D L F+LD + G+L + ++ +E R + A+I+ Sbjct: 320 LNRLS--NRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQIL 377 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-----------V 351 +++MH+ V++RDLKP NILLD+ ++I+D G A KK + V Sbjct: 378 DAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFV 437 Query: 352 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV 411 GT Y++PE+L+ D ++ GC++++++ G PF+ T + ++T + Sbjct: 438 GTAEYVSPELLENKYC-GKPGDVWAFGCIIYQMIAGKPPFKA--TNEYLTFQKIT-KLQF 493 Query: 412 ELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQ---MVFLQKYPP 468 F +R L++ +L +RR E+++ FF+S+D++ ++L P Sbjct: 494 AFSAGFPTIIRDLIKKILVLQPSRRATI-----PEIQKHYFFQSVDFKDFDSIWLSD--P 546 Query: 469 PLIPP 473 P I P Sbjct: 547 PEIGP 551 >4YZB-A nrPDB Length = 491 Score = 111 bits (277), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 69/202 (34%), Positives = 106/202 (52%), Gaps = 9/202 (4%) Query: 194 HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPF 253 R++G+G FGEV C+ TG+ YA+K + K+++K K T + L+ D P Sbjct: 35 QRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQK---TDKELLLKEVELLKKLDHPN 91 Query: 254 IVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFV 313 I+ + F + ++ GG+L + FSE D +++ G+ +MH + Sbjct: 92 IMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKI 151 Query: 314 VYRDLKPANILLD---EHGHVRISDLGLACDF-SKKKPHASVGTHGYMAPEVLQKGVAYD 369 V+RDLKP N+LL+ + ++RI D GL+ F S KK +GT Y+APEVL YD Sbjct: 152 VHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHG--TYD 209 Query: 370 SSADWFSLGCMLFKLLRGHSPF 391 D +S G +L+ LL G PF Sbjct: 210 EKCDVWSTGVILYILLSGCPPF 231 >4B6L-A nrPDB Length = 281 Score = 111 bits (277), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 73/238 (30%), Positives = 117/238 (49%), Gaps = 9/238 (3%) Query: 195 RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 254 R++G+GGF Y +TG YA+K + + R+ LNE + L I Sbjct: 15 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNE---IELHRDLQHRHI 71 Query: 255 VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVV 314 V S+ F D + L+L + L + E ++R+Y +I+ GL+++H R ++ Sbjct: 72 VRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGIL 131 Query: 315 YRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQKGVAYDSSA 372 +RDLK N + E+ +++ D GLA +++ GT Y+APEVL + + A Sbjct: 132 HRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQ-GHGPEA 190 Query: 373 DWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQ 430 D +SLGC+++ LL G PF +T D E R + LP S S R LL +L+ Sbjct: 191 DVWSLGCVMYTLLCGSPPF---ETADLKETYRCIKQVHYTLPASLSLPARQLLAAILR 245 >3D2K-A nrPDB Length = 272 Score = 110 bits (274), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 76/270 (28%), Positives = 133/270 (49%), Gaps = 14/270 (5%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 T+ DF + R +G+G FG VY R+ + + A+K L K +++ K G L + + Sbjct: 10 TLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLE-KAGVEHQLRREVEIQ-- 66 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 S P I+ + FH ++ IL+ G ++ L + F E Y E+ L Sbjct: 67 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALS 126 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGV 366 + H++ V++RD+KP N+LL +G ++I+D G + + GT Y+ PE+++ G Sbjct: 127 YCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIE-GR 185 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFSPELRSLL 425 +D D +SLG + ++ L G PF H ++ + I R+ T PD + R L+ Sbjct: 186 MHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFT----FPDFVTEGARDLI 241 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 LL+ + ++RL EV E P+ ++ Sbjct: 242 SRLLKHNASQRLTL-----AEVLEHPWIKA 266 >3MA6-A nrPDB Length = 298 Score = 109 bits (273), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 68/202 (33%), Positives = 107/202 (52%), Gaps = 9/202 (4%) Query: 194 HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPF 253 R++G+G FGEV C+ TG+ A+K + K+++K K + L E + L+ D P Sbjct: 37 QRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLRE---VQLLKQLDHPN 93 Query: 254 IVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFV 313 I+ + F + ++ GG+L + FSE D +++ G+ +MH + Sbjct: 94 IMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKI 153 Query: 314 VYRDLKPANILLD---EHGHVRISDLGLACDF-SKKKPHASVGTHGYMAPEVLQKGVAYD 369 V+RDLKP N+LL+ + ++RI D GL+ F + KK +GT Y+APEVL YD Sbjct: 154 VHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHG--TYD 211 Query: 370 SSADWFSLGCMLFKLLRGHSPF 391 D +S G +L+ LL G PF Sbjct: 212 EKCDVWSTGVILYILLSGCPPF 233 >4CZT-A nrPDB Length = 464 Score = 109 bits (272), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 62/205 (30%), Positives = 109/205 (53%), Gaps = 7/205 (3%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + R +G G F +V R + G A+K +DK+++ + E + L+ Sbjct: 13 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK--- 69 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P ++ M + K+ F+L+ + GG+L +S +G E + R Y ++I +++ H+ Sbjct: 70 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 129 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP----HASVGTHGYMAPEVLQKGV 366 R V +RDLKP N+LLD +G +++SD GL+ + + H + GT Y+APEV+ Sbjct: 130 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 189 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPF 391 + AD +S G +LF L+ G+ PF Sbjct: 190 YDGAKADLWSCGVILFVLMAGYLPF 214 >5JN2-A nrPDB Length = 525 Score = 108 bits (270), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 68/202 (33%), Positives = 107/202 (52%), Gaps = 9/202 (4%) Query: 194 HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPF 253 R++G+G FGEV C+ TG+ A+K + K+++K K + L E + L+ D P Sbjct: 72 QRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLRE---VQLLKQLDHPN 128 Query: 254 IVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFV 313 I+ + F + ++ GG+L + FSE D +++ G+ +MH + Sbjct: 129 IMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKI 188 Query: 314 VYRDLKPANILLD---EHGHVRISDLGLACDF-SKKKPHASVGTHGYMAPEVLQKGVAYD 369 V+RDLKP N+LL+ + ++RI D GL+ F + KK +GT Y+APEVL YD Sbjct: 189 VHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHG--TYD 246 Query: 370 SSADWFSLGCMLFKLLRGHSPF 391 D +S G +L+ LL G PF Sbjct: 247 EKCDVWSTGVILYILLSGCPPF 268 >5FG8-A nrPDB Length = 285 Score = 107 bits (267), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 74/258 (28%), Positives = 127/258 (49%), Gaps = 17/258 (6%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ + +G+G F V C + TG +A K ++ K++ + + L RI L Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHH- 72 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 P IV + + + + DL+ GG+L + +SEAD +I+ + H Sbjct: 73 ---PNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHC 129 Query: 309 HNRFVVYRDLKPANILLDEHGH---VRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQ 363 H VV+RDLKP N+LL V+++D GLA + + GT GY++PEVL+ Sbjct: 130 HQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLK 189 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSP 419 K Y S D ++ G +L+ LL G+ PF +D+H + A + P D+ +P Sbjct: 190 KE-PYGKSVDIWACGVILYILLVGYPPFWD---EDQHRLYSQIKAGAYDYPSPEWDTVTP 245 Query: 420 ELRSLLEGLLQRDVNRRL 437 E ++L+ +L + N+R+ Sbjct: 246 EAKNLINQMLTVNPNKRI 263 >3KK8-A nrPDB Length = 284 Score = 107 bits (266), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 72/257 (28%), Positives = 127/257 (49%), Gaps = 16/257 (6%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ V +G+G F V C TG +A K ++ K++ + + L RI L Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH- 64 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 P IV + + + DL+ GG+L + +SEAD +I+ + + Sbjct: 65 ---PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYC 121 Query: 309 HNRFVVYRDLKPANILLDEHGH---VRISDLGLACDFSKKKP-HASVGTHGYMAPEVLQK 364 H+ +V+R+LKP N+LL V+++D GLA + + + H GT GY++PEVL+K Sbjct: 122 HSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 181 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSPE 420 Y D ++ G +L+ LL G+ PF +D+H + A + P D+ +PE Sbjct: 182 D-PYSKPVDIWACGVILYILLVGYPPFWD---EDQHRLYAQIKAGAYDYPSPEWDTVTPE 237 Query: 421 LRSLLEGLLQRDVNRRL 437 +SL++ +L + +R+ Sbjct: 238 AKSLIDSMLTVNPKKRI 254 >5KZ7-A nrPDB Length = 346 Score = 107 bits (266), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 74/251 (29%), Positives = 126/251 (50%), Gaps = 10/251 (3%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + ++ + + IG+G F +V R TGK A+K +DK ++ + L RIM L Sbjct: 32 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVL-- 89 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 + P IV + T L +++ +GG++ +L HG E + R +I+ +++ Sbjct: 90 --NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 147 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKGV 366 H +F+V+RDLK N+LLD +++I+D G + +F+ K G+ Y APE+ Q G Sbjct: 148 CHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQ-GK 206 Query: 367 AYDS-SADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 YD D +SLG +L+ L+ G PF K E+ L +P S + +LL Sbjct: 207 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLK---ELRERVLRGKYRIPFYMSTDCENLL 263 Query: 426 EGLLQRDVNRR 436 + L + ++R Sbjct: 264 KKFLILNPSKR 274 >2WQN-A nrPDB Length = 310 Score = 107 bits (266), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 77/257 (29%), Positives = 128/257 (49%), Gaps = 11/257 (4%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 T+ +F + + IGRG F EVY G A+K + + + + E + L+ Sbjct: 30 TLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKE---IDLL 86 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS----QHGVFSEADMRFYAAEII 302 + P ++ +F ++L+ +L+L + GDL + Q + E + Y ++ Sbjct: 87 KQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLC 146 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK--PHASVGTHGYMAPE 360 LEHMH+R V++RD+KPAN+ + G V++ DLGL FS K H+ VGT YM+PE Sbjct: 147 SALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPE 206 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP-DSFSP 419 + + Y+ +D +SLGC+L+++ SPF K ++ LP D +S Sbjct: 207 RIHEN-GYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSE 265 Query: 420 ELRSLLEGLLQRDVNRR 436 ELR L+ + D +R Sbjct: 266 ELRQLVNMCINPDPEKR 282 >2BDW-A nrPDB Length = 362 Score = 106 bits (264), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 72/257 (28%), Positives = 127/257 (49%), Gaps = 16/257 (6%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ V +G+G F V C TG +A K ++ K++ + + L RI L Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH- 87 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 P IV + + + DL+ GG+L + +SEAD +I+ + + Sbjct: 88 ---PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYC 144 Query: 309 HNRFVVYRDLKPANILLDEHGH---VRISDLGLACDFSKKKP-HASVGTHGYMAPEVLQK 364 H+ +V+R+LKP N+LL V+++D GLA + + + H GT GY++PEVL+K Sbjct: 145 HSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 204 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSPE 420 Y D ++ G +L+ LL G+ PF +D+H + A + P D+ +PE Sbjct: 205 D-PYSKPVDIWACGVILYILLVGYPPFWD---EDQHRLYAQIKAGAYDYPSPEWDTVTPE 260 Query: 421 LRSLLEGLLQRDVNRRL 437 +SL++ +L + +R+ Sbjct: 261 AKSLIDSMLTVNPKKRI 277 >4B8L-A nrPDB Length = 286 Score = 105 bits (263), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 74/270 (27%), Positives = 129/270 (47%), Gaps = 12/270 (4%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 T++DF + R +G+G FG VY R+ + A+K L K +++ K+G L I + Sbjct: 12 FTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLE-KEGVEHQLRREI--EI 68 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 S P I+ M FH ++ +L+ G+L+ L +HG F E + E+ L Sbjct: 69 QSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADAL 128 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKG 365 + H R V++RD+KP N+L+ G ++I+D G + + GT Y+ PE+++ G Sbjct: 129 HYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIE-G 187 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 +D D + G + ++ L G PF + H R + + ++ P S + L+ Sbjct: 188 KTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETH---RRIVNVDLKFPPFLSDGSKDLI 244 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 LL+ +RL G V E P+ ++ Sbjct: 245 SKLLRYHPPQRLPLKG-----VMEHPWVKA 269 >5ES1-A nrPDB Length = 328 Score = 105 bits (262), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 73/251 (29%), Positives = 122/251 (48%), Gaps = 10/251 (3%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + ++ + R IG+G F +V R TG+ A+K +DK ++ + L RIM L Sbjct: 14 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGL-- 71 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 + P IV + T L +++ + G++ +L HG E + R +I+ + + Sbjct: 72 --NHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHY 129 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKGV 366 H + +V+RDLK N+LLD +++I+D G + +F+ K G+ Y APE+ Q G Sbjct: 130 CHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQ-GK 188 Query: 367 AYDS-SADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 YD D +SLG +L+ L+ G PF H K E+ L +P S + S+L Sbjct: 189 KYDGPEVDIWSLGVILYTLVSGSLPFDGHNLK---ELRERVLRGKYRVPFYMSTDCESIL 245 Query: 426 EGLLQRDVNRR 436 L + +R Sbjct: 246 RRFLVLNPAKR 256 >4RGJ-A nrPDB Length = 520 Score = 105 bits (262), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 76/224 (33%), Positives = 109/224 (48%), Gaps = 15/224 (6%) Query: 174 FCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE 233 F Q NV N + +I+G+G FGEV R TG YA+K + KK +K K + Sbjct: 50 FIQNSNVVFN-----EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDK 104 Query: 234 TLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEAD 293 L E +L ++ D I+ + F + + D+ GG+L + F E D Sbjct: 105 ESLLREVELLKML---DHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEID 161 Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLD----EHGHVRISDLGLACDFS-KKKPH 348 +I+ G+ +MH VV+RDLKP NILL+ E ++I D GL+ F KK Sbjct: 162 AARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMK 221 Query: 349 ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR 392 +GT Y+AP+VL YD D +S G +L+ LL G PF Sbjct: 222 DKIGTAYYIAPDVLHG--TYDEKCDIWSCGVILYILLSGCPPFN 263 >2W4O-A nrPDB Length = 349 Score = 105 bits (262), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 69/209 (33%), Positives = 108/209 (51%), Gaps = 21/209 (10%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL----DKKRIKMKQGETLALNERIMLSLV 246 F V +GRG VY C++ T K YA+K L DKK ++ + G L L+ Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSH------- 107 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 P I+ + F TP ++S +L+L+ GG+L + + G +SE D +I+ + Sbjct: 108 -----PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVA 162 Query: 307 HMHNRFVVYRDLKPANILLDE---HGHVRISDLGLACDFSKKKPHASV-GTHGYMAPEVL 362 ++H +V+RDLKP N+L ++I+D GL+ + +V GT GY APE+L Sbjct: 163 YLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEIL 222 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 +G AY D +S+G + + LL G PF Sbjct: 223 -RGCAYGPEVDMWSVGIITYILLCGFEPF 250 >4QMW-A nrPDB Length = 310 Score = 105 bits (261), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 65/196 (33%), Positives = 109/196 (55%), Gaps = 9/196 (4%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG+G FGEV+ T K+ A+K +D +++ E + + ++++S D P++ Sbjct: 37 IGKGSFGEVFKGIDNRTQKVVAIKIID-----LEEAEDEIEDIQQEITVLSQCDSPYVTK 91 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 ++ KL I++ + GG L + G E + EI+ GL+++H+ ++R Sbjct: 92 YYGSYLKDTKLWIIMEYLGGGSA-LDLLEPGPLDETQIATILREILKGLDYLHSEKKIHR 150 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVAYDSSADW 374 D+K AN+LL EHG V+++D G+A + K + VGT +MAPEV+++ AYDS AD Sbjct: 151 DIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AYDSKADI 209 Query: 375 FSLGCMLFKLLRGHSP 390 +SLG +L RG P Sbjct: 210 WSLGITAIELARGEPP 225 >5IG1-A nrPDB Length = 344 Score = 105 bits (261), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 67/249 (26%), Positives = 128/249 (51%), Gaps = 16/249 (6%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 +IG+G F V+ C TG++ A+K + K ++ + + + + + S+ IV Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKI----KREIGICSSLQHEHIV 79 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 M AF + + ++GG+L + ++E D +I+ L+H H++ +++ Sbjct: 80 SMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIH 139 Query: 316 RDLKPANILL---DEHGHVRISDLGLACDFSKKKPH-ASVGTHGYMAPEVLQKGVAYDSS 371 RDLKP N+LL D + V+I+D GLA + + GT GY++PEV+++ V YD++ Sbjct: 140 RDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRR-VPYDTA 198 Query: 372 ADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSPELRSLLEG 427 D ++ G +L+ LL G+ PF + +D ++ + P DS + + L++ Sbjct: 199 VDVWACGVILYILLVGYPPFWE---EDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKA 255 Query: 428 LLQRDVNRR 436 +L+ + RR Sbjct: 256 MLEPNPKRR 264 >4FG9-A nrPDB Length = 320 Score = 105 bits (261), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 75/258 (29%), Positives = 129/258 (50%), Gaps = 19/258 (7%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + ++G G F EV T K+ A+KC+ K+ ++ K+G NE +L + Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSME--NEIAVLHKIKH-- 75 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P IV + + + L I+ L++GG+L + + G ++E D +++ ++++H+ Sbjct: 76 -PNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHD 134 Query: 311 RFVVYRDLKPANIL---LDEHGHVRISDLGLACDFSKKKPHASV-----GTHGYMAPEVL 362 +V+RDLKP N+L LDE + ISD GL SK + SV GT GY+APEVL Sbjct: 135 LGIVHRDLKPENLLYYSLDEDSKIMISDFGL----SKMEDPGSVLSTACGTPGYVAPEVL 190 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPF-RQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 + Y + D +S+G + + LL G+ PF ++ K +I + D S Sbjct: 191 AQK-PYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSA 249 Query: 422 RSLLEGLLQRDVNRRLGC 439 + + L+++D +R C Sbjct: 250 KDFIRHLMEKDPEKRFTC 267 >3BHH-A nrPDB Length = 295 Score = 105 bits (261), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 75/258 (29%), Positives = 129/258 (50%), Gaps = 17/258 (6%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ ++ IG+G F V C K TG YA K ++ K++ + + L RI L + Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 IV + + + DL+ GG+L + +SEAD +I+ + H Sbjct: 64 N----IVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 119 Query: 309 HNRFVVYRDLKPANILLDEH---GHVRISDLGLACDFS--KKKPHASVGTHGYMAPEVLQ 363 H VV+RDLKP N+LL V+++D GLA + ++ GT GY++PEVL+ Sbjct: 120 HQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR 179 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSP 419 K AY D ++ G +L+ LL G+ PF +D+H++ + A + P D+ +P Sbjct: 180 KE-AYGKPVDIWACGVILYILLVGYPPFWD---EDQHKLYQQIKAGAYDFPSPEWDTVTP 235 Query: 420 ELRSLLEGLLQRDVNRRL 437 E ++L+ +L + +R+ Sbjct: 236 EAKNLINQMLTINPAKRI 253 >6C9D-A nrPDB Length = 459 Score = 104 bits (260), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 65/216 (30%), Positives = 112/216 (51%), Gaps = 7/216 (3%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + ++ + + IG+G F +V R TG+ A+K +DK ++ + L RIM L Sbjct: 20 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL-- 77 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 + P IV + T L +++ +GG++ +L HG E + R +I+ +++ Sbjct: 78 --NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 135 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKGV 366 H +++V+RDLK N+LLD +++I+D G + +F+ K G+ Y APE+ Q G Sbjct: 136 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQ-GK 194 Query: 367 AYDS-SADWFSLGCMLFKLLRGHSPFRQHKTKDKHE 401 YD D +SLG +L+ L+ G PF K+ E Sbjct: 195 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRE 230 >2JAM-A nrPDB Length = 304 Score = 104 bits (260), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 69/253 (27%), Positives = 128/253 (50%), Gaps = 11/253 (4%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F ++G G F EV+ ++ TGK++A+KC+ K+ + +L NE +L + + Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLE-NEIAVLKKIKHEN 67 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 IV + + + ++ L++GG+L + + GV++E D +++ ++++H Sbjct: 68 ---IVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHE 124 Query: 311 RFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVA 367 +V+RDLKP N+L +E+ + I+D GL+ + GT GY+APEVL + Sbjct: 125 NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQK-P 183 Query: 368 YDSSADWFSLGCMLFKLLRGHSPF-RQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLE 426 Y + D +S+G + + LL G+ PF + ++K +I D S + + Sbjct: 184 YSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFIC 243 Query: 427 GLLQRDVNRRLGC 439 LL++D N R C Sbjct: 244 HLLEKDPNERYTC 256 >2HAK-A nrPDB Length = 328 Score = 104 bits (259), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 65/216 (30%), Positives = 112/216 (51%), Gaps = 7/216 (3%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + ++ + + IG+G F +V R TG+ A+K +DK ++ + L RIM L Sbjct: 14 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL-- 71 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 + P IV + T L +++ +GG++ +L HG E + R +I+ +++ Sbjct: 72 --NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 129 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKGV 366 H +++V+RDLK N+LLD +++I+D G + +F+ K G+ Y APE+ Q G Sbjct: 130 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQ-GK 188 Query: 367 AYDS-SADWFSLGCMLFKLLRGHSPFRQHKTKDKHE 401 YD D +SLG +L+ L+ G PF K+ E Sbjct: 189 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRE 224 >2VN9-A nrPDB Length = 301 Score = 104 bits (259), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 73/258 (28%), Positives = 127/258 (49%), Gaps = 17/258 (6%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ + +G+G F V C K TG+ YA K ++ K++ + + L RI L Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH- 62 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 P IV + + + DL+ GG+L + +SEAD +I+ + H Sbjct: 63 ---PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 119 Query: 309 HNRFVVYRDLKPANILL---DEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQ 363 H +V+RDLKP N+LL + V+++D GLA + ++ GT GY++PEVL+ Sbjct: 120 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR 179 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSP 419 K Y D ++ G +L+ LL G+ PF +D+H + + A + P D+ +P Sbjct: 180 KD-PYGKPVDMWACGVILYILLVGYPPFWD---EDQHRLYQQIKAGAYDFPSPEWDTVTP 235 Query: 420 ELRSLLEGLLQRDVNRRL 437 E + L+ +L + +R+ Sbjct: 236 EAKDLINKMLTINPAKRI 253 >3LIJ-A nrPDB Length = 494 Score = 103 bits (258), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 78/265 (29%), Positives = 131/265 (49%), Gaps = 16/265 (6%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G +GEV CR T A+K + K + L L E +L L+ D P I+ Sbjct: 45 LGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKL-LEEVAVLKLL---DHPNIMK 100 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + F +++ GG+L + F+E D +++ G+ ++H +V+R Sbjct: 101 LYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHR 160 Query: 317 DLKPANILL---DEHGHVRISDLGLACDF-SKKKPHASVGTHGYMAPEVLQKGVAYDSSA 372 DLKP N+LL ++ ++I D GL+ F ++KK +GT Y+APEVL+K YD Sbjct: 161 DLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVLRK--KYDEKC 218 Query: 373 DWFSLGCMLFKLLRGHSPF-RQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQR 431 D +S+G +LF LL G+ PF Q + ++++ T + S + L++ +LQ Sbjct: 219 DVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLIKQMLQF 278 Query: 432 DVNRRLGCLGRGAQEVKESPFFRSL 456 D RR+ AQ+ E P+ + + Sbjct: 279 DSQRRI-----SAQQALEHPWIKEM 298 >4JXF-A nrPDB Length = 266 Score = 103 bits (258), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 77/269 (28%), Positives = 134/269 (49%), Gaps = 19/269 (7%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 DF V ++G+G F VY TG A+K +DKK + K G + + + Sbjct: 8 DFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAM-YKAGMVQRVQNEVKIH--CQL 64 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLEHM 308 P I+ + F + + +L++ + G+++ +L FSE + R + +II G+ ++ Sbjct: 65 KHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYL 124 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS----VGTHGYMAPEVLQK 364 H+ +++RDL +N+LL + +++I+D GLA K PH GT Y++PE+ + Sbjct: 125 HSHGILHRDLTLSNLLLTRNMNIKIADFGLATQL--KMPHEKHYTLCGTPNYISPEIATR 182 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 424 A+ +D +SLGCM + LL G PF K+ ++++ L E+P S E + L Sbjct: 183 S-AHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNT--LNKVVLA-DYEMPSFLSIEAKDL 238 Query: 425 LEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 + LL+R+ RL V + PF Sbjct: 239 IHQLLRRNPADRLSL-----SSVLDHPFM 262 >2Y7J-A nrPDB Length = 365 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 81/275 (29%), Positives = 129/275 (46%), Gaps = 29/275 (10%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLD--KKRIKMKQGETL-ALNERIMLSLVSTGDCP 252 +IGRG V C TG +A+K ++ +R+ +Q E + R L P Sbjct: 101 VIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHP 160 Query: 253 FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF 312 I+ + ++ + + + DLM G+L +L++ SE + R ++ + +H Sbjct: 161 HIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANN 220 Query: 313 VVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQKGV----- 366 +V+RDLKP NILLD++ +R+SD G +C +K GT GY+APE+L+ + Sbjct: 221 IVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHP 280 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSF-SPE----- 420 Y D ++ G +LF LL G PF H + L M +E F SPE Sbjct: 281 GYGKEVDLWACGVILFTLLAGSPPF-------WHRRQILMLRMIMEGQYQFSSPEWDDRS 333 Query: 421 --LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 ++ L+ LLQ D RL A++ + PFF Sbjct: 334 STVKDLISRLLQVDPEARL-----TAEQALQHPFF 363 >2VZ6-A nrPDB Length = 313 Score = 102 bits (255), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 74/250 (29%), Positives = 122/250 (48%), Gaps = 17/250 (6%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G+G F V C K G+ YA K ++ K++ + + L RI L P IV Sbjct: 30 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH----PNIVR 85 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + + I DL+ GG+L + +SEAD +I+ + H H VV+R Sbjct: 86 LHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHR 145 Query: 317 DLKPANILLDEH---GHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLQKGVAYDSS 371 DLKP N+LL V+++D GLA + ++ GT GY++PEVL+K Y Sbjct: 146 DLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD-PYGKP 204 Query: 372 ADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSPELRSLLEG 427 D ++ G +L+ LL G+ PF +D+H + + A + P D+ +PE + L+ Sbjct: 205 VDLWACGVILYILLVGYPPFWD---EDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 261 Query: 428 LLQRDVNRRL 437 +L + ++R+ Sbjct: 262 MLTINPSKRI 271 >4UZD-A nrPDB Length = 287 Score = 102 bits (255), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 69/251 (27%), Positives = 124/251 (49%), Gaps = 9/251 (3%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 + DF + R +G+G FG VY R+ + + A+K L K +++ K G L + + Sbjct: 6 ALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE-KAGVEHQLRREVEIQ-- 62 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 S P I+ + FH ++ IL+ G ++ L + F E Y E+ L Sbjct: 63 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 122 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGV 366 + H++ V++RD+KP N+LL G ++I+D G + + GT Y+ PE+++ G Sbjct: 123 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIE-GR 181 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSFSPELRSLL 425 +D D +SLG + ++ L G PF + ++ ++ I R+ T PD + R L+ Sbjct: 182 MHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFT----FPDFVTEGARDLI 237 Query: 426 EGLLQRDVNRR 436 LL+ + ++R Sbjct: 238 SRLLKHNPSQR 248 >5U6Y-A nrPDB Length = 461 Score = 102 bits (255), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 74/250 (29%), Positives = 122/250 (48%), Gaps = 17/250 (6%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G+G F V C K G+ YA K ++ K++ + + L RI L P IV Sbjct: 8 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH----PNIVR 63 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + + I DL+ GG+L + +SEAD +I+ + H H VV+R Sbjct: 64 LHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHR 123 Query: 317 DLKPANILLDEH---GHVRISDLGLACDFSKKKPH--ASVGTHGYMAPEVLQKGVAYDSS 371 DLKP N+LL V+++D GLA + ++ GT GY++PEVL+K Y Sbjct: 124 DLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD-PYGKP 182 Query: 372 ADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSPELRSLLEG 427 D ++ G +L+ LL G+ PF +D+H + + A + P D+ +PE + L+ Sbjct: 183 VDLWACGVILYILLVGYPPFWD---EDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 239 Query: 428 LLQRDVNRRL 437 +L + ++R+ Sbjct: 240 MLTINPSKRI 249 >6FDY-U nrPDB Length = 276 Score = 102 bits (254), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 74/255 (29%), Positives = 122/255 (47%), Gaps = 9/255 (3%) Query: 188 MNDFSVHRIIGRGGFGEVY-GCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 ++ F + +G G + VY K DT ++ A+KC+ KK + E L I+ + Sbjct: 10 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIR 69 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 P IV + D + I++ GGDL + + E R + ++ L+ Sbjct: 70 H----PHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQ 125 Query: 307 HMHNRFVVYRDLKPANILLD--EHGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQ 363 +H R + + DLKP NILL E H++++D G A S + H G+ YMAPE++ Sbjct: 126 FLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVC 185 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 + YD+ D +S+G +L++ L G PF + E R + + L S + R Sbjct: 186 QR-QYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRD 244 Query: 424 LLEGLLQRDVNRRLG 438 LL+ LL+RD +RR+ Sbjct: 245 LLQRLLERDPSRRIS 259 >2V7O-A nrPDB Length = 336 Score = 102 bits (254), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 72/258 (27%), Positives = 127/258 (49%), Gaps = 17/258 (6%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +D+ + +G+G F V C K + YA K ++ K++ + + L RI L Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKH- 89 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 P IV + + + DL+ GG+L + +SEAD +I+ + H+ Sbjct: 90 ---PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHI 146 Query: 309 HNRFVVYRDLKPANILLDEH---GHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLQ 363 H +V+RDLKP N+LL V+++D GLA + ++ GT GY++PEVL+ Sbjct: 147 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLR 206 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSP 419 K Y D ++ G +L+ LL G+ PF +D+H++ + A + P D+ +P Sbjct: 207 KD-PYGKPVDIWACGVILYILLVGYPPFWD---EDQHKLYQQIKAGAYDFPSPEWDTVTP 262 Query: 420 ELRSLLEGLLQRDVNRRL 437 E ++L+ +L + +R+ Sbjct: 263 EAKNLINQMLTINPAKRI 280 >6CMJ-A nrPDB Length = 321 Score = 101 bits (252), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 69/265 (26%), Positives = 134/265 (50%), Gaps = 17/265 (6%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM--- 242 + ++ +++ IG+G +G V + YAMK L KK++ + G + I Sbjct: 31 VQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVY 90 Query: 243 --LSLVSTGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYA 298 ++++ D P +V + P D L + +L+N G + + SE RFY Sbjct: 91 QEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPV-MEVPTLKPLSEDQARFYF 149 Query: 299 AEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGY 356 ++I G+E++H + +++RD+KP+N+L+ E GH++I+D G++ +F S +VGT + Sbjct: 150 QDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAF 209 Query: 357 MAPEVLQ--KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP 414 MAPE L + + + D +++G L+ + G PF + H + + A+E P Sbjct: 210 MAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIK---SQALEFP 266 Query: 415 D--SFSPELRSLLEGLLQRDVNRRL 437 D + +L+ L+ +L ++ R+ Sbjct: 267 DQPDIAEDLKDLITRMLDKNPESRI 291 >2QNJ-A nrPDB Length = 328 Score = 101 bits (252), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 72/244 (29%), Positives = 121/244 (49%), Gaps = 10/244 (4%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + ++ + + IG+G F +V R TG+ A+K +DK ++ + L RIM L Sbjct: 11 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKIL-- 68 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 + P IV + T L I++ +GG++ +L HG E + R +I+ +++ Sbjct: 69 --NHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQY 126 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKGV 366 H + +V+RDLK N+LLD +++I+D G + +F+ K G+ Y APE+ Q G Sbjct: 127 CHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQ-GK 185 Query: 367 AYDS-SADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 YD D +SLG +L+ L+ G PF K E+ L +P S + +LL Sbjct: 186 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLK---ELRERVLRGKYRIPFYMSTDCENLL 242 Query: 426 EGLL 429 + L Sbjct: 243 KRFL 246 >3KN6-A nrPDB Length = 325 Score = 101 bits (252), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 82/270 (30%), Positives = 127/270 (47%), Gaps = 46/270 (17%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G F C + + +A+K + K+ Q E AL + G P IV Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALK-------LCEGH-PNIVK 70 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + FH +++L+NGG+L + + FSE + + +++ + HMH+ VV+R Sbjct: 71 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 130 Query: 317 DLKPANILL-DEHGH--VRISDLGLACDFSKKKP------HASVGTHGYMAPEVLQKGVA 367 DLKP N+L DE+ + ++I D G F++ KP T Y APE+L + Sbjct: 131 DLKPENLLFTDENDNLEIKIIDFG----FARLKPPDNQPLKTPCFTLHYAAPELLNQN-G 185 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDR-MTLTMAVELP------------ 414 YD S D +SLG +L+ +L G PF+ H DR +T T AVE+ Sbjct: 186 YDESCDLWSLGVILYTMLSGQVPFQSH--------DRSLTCTSAVEIMKKIKKGDFSFEG 237 Query: 415 ---DSFSPELRSLLEGLLQRDVNRRLGCLG 441 + S E + L++GLL D N+RL G Sbjct: 238 EAWKNVSQEAKDLIQGLLTVDPNKRLKMSG 267 >3NCG-A nrPDB Length = 486 Score = 101 bits (251), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 67/205 (32%), Positives = 106/205 (51%), Gaps = 10/205 (4%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 +++ ++G+G FGEV C+ T + YA+K ++K K K T+ L E + L+ D Sbjct: 24 YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTI-LRE---VELLKKLD 79 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P I+ + + +L GG+L + + FSE D ++ G+ +MH Sbjct: 80 HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHK 139 Query: 311 RFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKK-KPHASVGTHGYMAPEVLQKGV 366 +V+RDLKP NILL ++ ++I D GL+ F + K +GT Y+APEVL+ Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG-- 197 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPF 391 YD D +S G +L+ LL G PF Sbjct: 198 TYDEKCDVWSAGVILYILLSGTPPF 222 >5J5T-A nrPDB Length = 370 Score = 101 bits (251), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 81/276 (29%), Positives = 135/276 (48%), Gaps = 50/276 (18%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 + DF + + IG G +G+VY R +TG++ A+K IK++ GE A+ + ++ Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKV-----IKLEPGEDFAV---VQQEII 53 Query: 247 STGDC--PFIVCMSYAFHTPDKLSFILDLMNGGDLH--YHLSQHGVFSEADMRFYAAEII 302 DC P IV ++ DKL ++ GG L YH++ G SE + + + E + Sbjct: 54 MMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYVSRETL 111 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPE 360 GL ++H++ ++RD+K ANILL ++GHV+++D G++ + K A +GT +MAPE Sbjct: 112 QGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPE 171 Query: 361 V--LQKGVAYDSSADWFSLGCMLFKL-----------------LRGHSPFRQHKTKDK-- 399 V +++ Y+ D +++G +L L S F+ K KDK Sbjct: 172 VAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMK 231 Query: 400 -----HEIDRMTLTMAVELPDSFSPELRSLLEGLLQ 430 H +M LT +P+ R E LLQ Sbjct: 232 WSNSFHHFVKMALTK--------NPKKRPTAEKLLQ 259 >2OU7-A nrPDB Length = 335 Score = 100 bits (248), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 71/244 (29%), Positives = 121/244 (49%), Gaps = 13/244 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGETLALNERIMLSLVSTGDCPFIV 255 +G+GGF + + ADT +++A K + K + K Q E +++ I SL +V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQ----HVV 104 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 F D + +L+L L + +E + R+Y +I+LG +++H V++ Sbjct: 105 GFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIH 164 Query: 316 RDLKPANILLDEHGHVRISDLGLA--CDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSAD 373 RDLK N+ L+E V+I D GLA ++ ++ GT Y+APEVL K + D Sbjct: 165 RDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKK-GHSFEVD 223 Query: 374 WFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFSPELRSLLEGLLQRD 432 +S+GC+++ LL G PF K+ + I + + +P +P SL++ +LQ D Sbjct: 224 VWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYS----IPKHINPVAASLIQKMLQTD 279 Query: 433 VNRR 436 R Sbjct: 280 PTAR 283 >4J52-A nrPDB Length = 293 Score = 100 bits (248), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 71/244 (29%), Positives = 121/244 (49%), Gaps = 13/244 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGETLALNERIMLSLVSTGDCPFIV 255 +G+GGF + + ADT +++A K + K + K Q E +++ I SL +V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQ----HVV 77 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 F D + +L+L L + +E + R+Y +I+LG +++H V++ Sbjct: 78 GFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIH 137 Query: 316 RDLKPANILLDEHGHVRISDLGLA--CDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSAD 373 RDLK N+ L+E V+I D GLA ++ ++ GT Y+APEVL K + D Sbjct: 138 RDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKK-GHSFEVD 196 Query: 374 WFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFSPELRSLLEGLLQRD 432 +S+GC+++ LL G PF K+ + I + + +P +P SL++ +LQ D Sbjct: 197 VWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYS----IPKHINPVAASLIQKMLQTD 252 Query: 433 VNRR 436 R Sbjct: 253 PTAR 256 >3DFA-A nrPDB Length = 286 Score = 99.8 bits (247), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 76/247 (30%), Positives = 126/247 (51%), Gaps = 17/247 (6%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 +++ ++G+G FGEV C+ T + YA+K ++K K K T+ L E + L+ D Sbjct: 24 YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTI-LRE---VELLKKLD 79 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P I+ + + +L GG+L + + FSE D ++ G+ +MH Sbjct: 80 HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHK 139 Query: 311 RFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKK-KPHASVGTHGYMAPEVLQKGV 366 +V+RDLKP NILL ++ ++I D GL+ F + K +GT Y+APEVL+ Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG-- 197 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT--MAVELPD--SFSPELR 422 YD D +S G +L+ LL G PF K++++I + T A +LP + S + + Sbjct: 198 TYDEKCDVWSAGVILYILLSGTPPFY---GKNEYDILKRVETGKYAFDLPQWRTISDDAK 254 Query: 423 SLLEGLL 429 L+ +L Sbjct: 255 DLIRKML 261 >3DB8-A nrPDB Length = 317 Score = 99.4 bits (246), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 75/255 (29%), Positives = 127/255 (49%), Gaps = 15/255 (5%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQGETLALNERIMLSL 245 TM + R +G+GGF + Y DT +++A K + K + K Q E ++ I SL Sbjct: 40 TMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSL 99 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 D P +V F D + +L++ L + +E + R++ + I G+ Sbjct: 100 ----DNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGV 155 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC--DFSKKKPHASVGTHGYMAPEVL- 362 +++HN V++RDLK N+ L++ V+I D GLA +F ++ GT Y+APEVL Sbjct: 156 QYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLC 215 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFSPEL 421 +KG +++ D +SLGC+L+ LL G PF K+ + I + + +P +P Sbjct: 216 KKGHSFE--VDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYS----VPRHINPVA 269 Query: 422 RSLLEGLLQRDVNRR 436 +L+ +L D R Sbjct: 270 SALIRRMLHADPTLR 284 >3SOA-A nrPDB Length = 444 Score = 99.4 bits (246), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 72/250 (28%), Positives = 121/250 (48%), Gaps = 17/250 (6%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G+G F V C K G+ YA ++ K++ + + L RI L P IV Sbjct: 19 LGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH----PNIVR 74 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + + I DL+ GG+L + +SEAD +I+ + H H VV+R Sbjct: 75 LHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHR 134 Query: 317 DLKPANILLDEH---GHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLQKGVAYDSS 371 +LKP N+LL V+++D GLA + ++ GT GY++PEVL+K Y Sbjct: 135 NLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD-PYGKP 193 Query: 372 ADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSPELRSLLEG 427 D ++ G +L+ LL G+ PF +D+H + + A + P D+ +PE + L+ Sbjct: 194 VDLWACGVILYILLVGYPPFWD---EDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 250 Query: 428 LLQRDVNRRL 437 +L + ++R+ Sbjct: 251 MLTINPSKRI 260 >4CFH-A nrPDB Length = 493 Score = 98.6 bits (244), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 75/261 (28%), Positives = 128/261 (49%), Gaps = 16/261 (6%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G FG+V + TG A+K L++++I+ E L L P I+ Sbjct: 41 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH---PHIIK 97 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + TP + +++ ++GG+L ++ ++G E + R +I+ G+++ H VV+R Sbjct: 98 LYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHR 157 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGVAYDSSADWF 375 DLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ + D + Sbjct: 158 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 217 Query: 376 SLGCMLFKLLRGHSPFRQHK--TKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDV 433 S G +L+ LL G PF T K D + T P +P + SLL+ +LQ D Sbjct: 218 SSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYT-----PQYLNPSVISLLKHMLQVDP 272 Query: 434 NRRLGCLGRGAQEVKESPFFR 454 +R ++++E +F+ Sbjct: 273 MKRATI-----KDIREHEWFK 288 >3UDB-A nrPDB Length = 317 Score = 98.6 bits (244), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 85/305 (27%), Positives = 133/305 (43%), Gaps = 35/305 (11%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G FG R ++ A+K +++ GE + N + + + P IV Sbjct: 27 IGAGNFGVARLMRDKQANELVAVKYIER-------GEKIDENVKREIINHRSLRHPNIVR 79 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 TP L+ +++ +GG+L + G FSE + RF+ ++I G+ + H V +R Sbjct: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAMQVAHR 139 Query: 317 DLKPANILLD--EHGHVRISDLGLA-CDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSAD 373 DLK N LLD ++I+D G + +P ++VGT Y+APEVL K AD Sbjct: 140 DLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEYDGKVAD 199 Query: 374 WFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAVELPD--SFSPELRSLLEGLLQ 430 +S G L+ +L G PF + K+ + L + +PD SPE R L+ + Sbjct: 200 VWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFV 259 Query: 431 RDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDE 490 D +R+ P R+ +W FL+ P L+ D FDE Sbjct: 260 ADPAKRISI-----------PEIRNHEW---FLKNLPADLM--------NDNTMTTQFDE 297 Query: 491 EDTKG 495 D G Sbjct: 298 SDQPG 302 >4REW-A nrPDB Length = 540 Score = 98.2 bits (243), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 75/261 (28%), Positives = 128/261 (49%), Gaps = 16/261 (6%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G FG+V + TG A+K L++++I+ E L L P I+ Sbjct: 14 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH---PHIIK 70 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + TP + +++ ++GG+L ++ ++G E + R +I+ G+++ H VV+R Sbjct: 71 LYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHR 130 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGVAYDSSADWF 375 DLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ + D + Sbjct: 131 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 190 Query: 376 SLGCMLFKLLRGHSPFRQHK--TKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDV 433 S G +L+ LL G PF T K D + T P +P + SLL+ +LQ D Sbjct: 191 SSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYT-----PQYLNPSVISLLKHMLQVDP 245 Query: 434 NRRLGCLGRGAQEVKESPFFR 454 +R ++++E +F+ Sbjct: 246 MKRASI-----KDIREHEWFK 261 >4RED-A nrPDB Length = 351 Score = 98.2 bits (243), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 75/261 (28%), Positives = 128/261 (49%), Gaps = 16/261 (6%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G FG+V + TG A+K L++++I+ E L L P I+ Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH---PHIIK 78 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + TP + +++ ++GG+L ++ ++G E + R +I+ G+++ H VV+R Sbjct: 79 LYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHR 138 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGVAYDSSADWF 375 DLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ + D + Sbjct: 139 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 Query: 376 SLGCMLFKLLRGHSPFRQHK--TKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDV 433 S G +L+ LL G PF T K D + T P +P + SLL+ +LQ D Sbjct: 199 SSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYT-----PQYLNPSVISLLKHMLQVDP 253 Query: 434 NRRLGCLGRGAQEVKESPFFR 454 +R ++++E +F+ Sbjct: 254 MKR-----ASIKDIREHEWFK 269 >5XZW-A nrPDB Length = 471 Score = 98.2 bits (243), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 76/269 (28%), Positives = 133/269 (49%), Gaps = 32/269 (11%) Query: 190 DFSV-HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 DFS+ ++G+G F V + TGK +A+K + K+++ G + L ++ Sbjct: 196 DFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVI---GNMDGVTRE--LEVLQK 250 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 + P IV + + + +++ ++GGDL ++ HG E R + +I+ ++++ Sbjct: 251 LNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYI 310 Query: 309 HNRFVVYRDLKPANILL--DEHGHVRISDLGLACDFSKKKPHAS-----VGTHGYMAPEV 361 H+ + +RDLKP NIL+ D+ V+I+D GLA K + + S GT Y+APEV Sbjct: 311 HSMGISHRDLKPDNILIEQDDPVLVKITDFGLA----KVQGNGSFMKTFCGTLAYVAPEV 366 Query: 362 L------------QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK--HEIDRMTL 407 + ++ Y S D +S+GC+++ +L GH PF T+D+ +I R + Sbjct: 367 IRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF-SGSTQDQLYKQIGRGSY 425 Query: 408 TMAVELPDSFSPELRSLLEGLLQRDVNRR 436 S E R ++ LLQ D N R Sbjct: 426 HEGPLKDFRISEEARDFIDSLLQVDPNNR 454 >3Q5I-A nrPDB Length = 504 Score = 97.8 bits (242), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 72/254 (28%), Positives = 122/254 (48%), Gaps = 14/254 (5%) Query: 195 RIIGRGGFGEVYGCRKADTGKMYAMKCL-----DKKRIKMKQGETLALNERIM--LSLVS 247 R +G G +GEV C++ + A+K + DK R +E I +SL+ Sbjct: 42 RKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLK 101 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 + D P I+ + F + + GG+L + F E D +I+ G+ + Sbjct: 102 SLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICY 161 Query: 308 MHNRFVVYRDLKPANILLDEHG---HVRISDLGLACDFSKK-KPHASVGTHGYMAPEVLQ 363 +H +V+RD+KP NILL+ +++I D GL+ FSK K +GT Y+APEVL+ Sbjct: 162 LHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVLK 221 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-KHEIDRMTLTMAVELPDSFSPELR 422 K Y+ D +S G +++ LL G+ PF +D ++++ + S E + Sbjct: 222 K--KYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISDEAK 279 Query: 423 SLLEGLLQRDVNRR 436 L++ +L D N+R Sbjct: 280 ELIKLMLTYDYNKR 293 >2YCR-A nrPDB Length = 323 Score = 97.4 bits (241), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 63/217 (29%), Positives = 115/217 (52%), Gaps = 9/217 (4%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL--ALNERIMLSLV 246 +++ + + +G G GEV + T K A+K + K++ + ALN + ++ Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + P I+ + F D +L+LM GG+L + + EA + Y +++L ++ Sbjct: 70 KKLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 128 Query: 307 HMHNRFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKKPHASV-GTHGYMAPEVL 362 ++H +++RDLKP N+LL +E ++I+D G + + ++ GT Y+APEVL Sbjct: 129 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 188 Query: 363 -QKGVA-YDSSADWFSLGCMLFKLLRGHSPFRQHKTK 397 G A Y+ + D +SLG +LF L G+ PF +H+T+ Sbjct: 189 VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQ 225 >2XIK-A nrPDB Length = 294 Score = 97.4 bits (241), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 63/196 (32%), Positives = 107/196 (54%), Gaps = 9/196 (4%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG+G FGEVY T ++ A+K +D +++ E + + ++++S D P+I Sbjct: 27 IGKGSFGEVYKGIDNHTKEVVAIKIID-----LEEAEDEIEDIQQEITVLSQCDSPYITR 81 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 ++ KL I++ + GG L + G E + EI+ GL+++H+ ++R Sbjct: 82 YFGSYLKSTKLWIIMEYLGGGSA-LDLLKPGPLEETYIATILREILKGLDYLHSERKIHR 140 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVAYDSSADW 374 D+K AN+LL E G V+++D G+A + K + VGT +MAPEV+++ AYD AD Sbjct: 141 DIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AYDFKADI 199 Query: 375 FSLGCMLFKLLRGHSP 390 +SLG +L +G P Sbjct: 200 WSLGITAIELAKGEPP 215 >4APC-A nrPDB Length = 350 Score = 97.4 bits (241), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 70/251 (27%), Positives = 127/251 (50%), Gaps = 25/251 (9%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G FG+ + + G+ Y +K ++ R+ K+ E R +++++ P IV Sbjct: 32 IGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKERE----ESRREVAVLANMKHPNIVQ 87 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHL-SQHGV-FSEADMRFYAAEIILGLEHMHNRFVV 314 +F L ++D GGDL + +Q GV F E + + +I L L+H+H+R ++ Sbjct: 88 YRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKIL 147 Query: 315 YRDLKPANILLDEHGHVRISDLGLA--CDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSA 372 +RD+K NI L + G V++ D G+A + + + A +GT Y++PE+ + Y++ + Sbjct: 148 HRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENK-PYNNKS 206 Query: 373 DWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSP-------ELRSLL 425 D ++LGC+L++L F K+ L + + + SF P +LRSL+ Sbjct: 207 DIWALGCVLYELCTLKHAFEAGSMKN--------LVLKI-ISGSFPPVSLHYSYDLRSLV 257 Query: 426 EGLLQRDVNRR 436 L +R+ R Sbjct: 258 SQLFKRNPRDR 268 >4FZF-B nrPDB Length = 283 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 70/245 (28%), Positives = 123/245 (50%), Gaps = 17/245 (6%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG+G FGEV+ T ++ A+K +D +++ E + + ++++S D ++ Sbjct: 16 IGKGSFGEVFKGIDNRTQQVVAIKIID-----LEEAEDEIEDIQQEITVLSQCDSSYVTK 70 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 ++ KL I++ + GG L + G F E + EI+ GL+++H+ ++R Sbjct: 71 YYGSYLKGSKLWIIMEYLGGGS-ALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHR 129 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVAYDSSADW 374 D+K AN+LL E G V+++ G+A + K + VGT +MAPEV+Q+ AYDS AD Sbjct: 130 DIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQS-AYDSKADI 188 Query: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPD---SFSPELRSLLEGLLQR 431 +SLG +L +G P D H + + L P F+ + ++ L + Sbjct: 189 WSLGITAIELAKGEPP-----NSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNK 243 Query: 432 DVNRR 436 D + R Sbjct: 244 DPSFR 248 >4YNZ-A nrPDB Length = 342 Score = 97.1 bits (240), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 69/250 (27%), Positives = 126/250 (50%), Gaps = 12/250 (4%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + + +G+G G V T + A+K ++++++ E++ + ++++ + Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKL----SESVLMKVEREIAILKLIE 67 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P ++ + + L +L+ ++GG+L +L + G + + R + +II L+ H+ Sbjct: 68 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 127 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLAC-DFSKKKPHASVGTHGYMAPEVLQKGVAYD 369 + +RDLKP N+LLDE ++RI+D G+A S G+ Y PEV+ +G YD Sbjct: 128 HSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVI-RGEKYD 186 Query: 370 S-SADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSFSPELRSLLEG 427 AD +S G +LF LL G PF + E + R M P P+ +SLL G Sbjct: 187 GRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHM----PHFIPPDCQSLLRG 242 Query: 428 LLQRDVNRRL 437 +++ D RRL Sbjct: 243 MIEVDAARRL 252 >5JZN-A nrPDB Length = 280 Score = 96.7 bits (239), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 75/272 (27%), Positives = 129/272 (47%), Gaps = 21/272 (7%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + V R IG G F V C + T + YA+K + K + + K E + NE +L V Sbjct: 21 YKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGK--EHMIQNEVSILRRVKH-- 76 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P IV + P +L +++L+ GGDL ++ ++E D + ++++H+ Sbjct: 77 -PNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHS 135 Query: 311 RFVVYRDLKPANILLDEH----GHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGV 366 +V+RD+KP N+L+ EH +++ D GLA + GT Y+APE++ + Sbjct: 136 LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLAT-IVDGPLYTVCGTPTYVAPEIIAE-T 193 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSPELR 422 Y D ++ G + + LL G PFR + D++ L V+ P D+ S + Sbjct: 194 GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQI-LMGQVDFPSPYWDNVSDSAK 252 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 L+ +L DV++R A +V E P+ Sbjct: 253 ELITMMLLVDVDQRF-----SAVQVLEHPWVN 279 >5YV8-A nrPDB Length = 298 Score = 96.3 bits (238), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 70/280 (25%), Positives = 136/280 (48%), Gaps = 32/280 (11%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG------------- 232 + +N +++ IG+G +G V + YAMK L KK++ + G Sbjct: 10 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 69 Query: 233 -----ETLALNERIM--LSLVSTGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHL 283 + E++ ++++ D P +V + P D L + +L+N G + + Sbjct: 70 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPV-MEV 128 Query: 284 SQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF- 342 SE RFY ++I G+E++H + +++RD+KP+N+L+ E GH++I+D G++ +F Sbjct: 129 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 188 Query: 343 -SKKKPHASVGTHGYMAPEVLQ--KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 399 S +VGT +MAPE L + + + D +++G L+ + G PF + Sbjct: 189 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 248 Query: 400 HEIDRMTLTMAVELPD--SFSPELRSLLEGLLQRDVNRRL 437 H + + A+E PD + +L+ L+ +L ++ R+ Sbjct: 249 HSKIK---SQALEFPDQPDIAEDLKDLITRMLDKNPESRI 285 >4NIF-A nrPDB Length = 333 Score = 96.3 bits (238), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 81/284 (28%), Positives = 134/284 (47%), Gaps = 35/284 (12%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + V IG G + E C T YA+K +DK K E + + L+ Sbjct: 8 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKS--KRDPSEEIEI-------LLRY 58 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 G P I+ + + + + +LM GG+L + + FSE + F I +E++ Sbjct: 59 GQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYL 118 Query: 309 HNRFVVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKPHASVG-------THGYM 357 H++ VV+RDLKP+NIL +DE G+ +RI D G A K+ A G T ++ Sbjct: 119 HSQGVVHRDLKPSNILYVDESGNPECLRICDFGFA-----KQLRAENGLLMTPCYTANFV 173 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE----IDRMTLTMAVEL 413 APEVL++ YD D +SLG +L+ +L G++PF + E I T++ Sbjct: 174 APEVLKRQ-GYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGN 232 Query: 414 PDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 ++ S + L+ +L D ++RL A++V + P+ D Sbjct: 233 WNTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQHPWVTQKD 271 >3HZT-A nrPDB Length = 467 Score = 95.5 bits (236), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 62/199 (31%), Positives = 98/199 (49%), Gaps = 9/199 (4%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G +GEV C+ TG A+K + K + L+E +L + D P I+ Sbjct: 12 LGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL---DHPNIMK 68 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + F ++++ GG+L + FSE D +++ G ++H +V+R Sbjct: 69 LYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNIVHR 128 Query: 317 DLKPANILLDEHGH---VRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKGVAYDSSA 372 DLKP N+LL+ ++I D GL+ F K +GT Y+APEVL+K YD Sbjct: 129 DLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLRK--KYDEKC 186 Query: 373 DWFSLGCMLFKLLRGHSPF 391 D +S G +L+ LL G+ PF Sbjct: 187 DVWSCGVILYILLCGYPPF 205 >3DXN-A nrPDB Length = 287 Score = 95.5 bits (236), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 62/199 (31%), Positives = 98/199 (49%), Gaps = 9/199 (4%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G +GEV C+ TG A+K + K + L+E +L + D P I+ Sbjct: 29 LGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL---DHPNIMK 85 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + F ++++ GG+L + FSE D +++ G ++H +V+R Sbjct: 86 LYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNIVHR 145 Query: 317 DLKPANILLDEHGH---VRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKGVAYDSSA 372 DLKP N+LL+ ++I D GL+ F K +GT Y+APEVL+K YD Sbjct: 146 DLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLRK--KYDEKC 203 Query: 373 DWFSLGCMLFKLLRGHSPF 391 D +S G +L+ LL G+ PF Sbjct: 204 DVWSCGVILYILLCGYPPF 222 >5WAX-A nrPDB Length = 310 Score = 95.5 bits (236), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 75/273 (27%), Positives = 124/273 (45%), Gaps = 26/273 (9%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + R IG G FG R G++ A+K +++ + + +N R + Sbjct: 13 YELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHRSLRH------ 66 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P I+ TP L+ +++ +GG+L + G FSE + RF+ ++I G+ + H+ Sbjct: 67 -PNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHS 125 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-------PHASVGTHGYMAPEVLQ 363 V +RDLK N LLD R+ CDF K P ++VGT Y+APEVL Sbjct: 126 MQVCHRDLKLENTLLDGSTAPRLK----ICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 181 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAVELPD--SFSPE 420 K AD +S G L+ +L G PF + K+ + + L + +PD SPE Sbjct: 182 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPE 241 Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 + L+ + + R+ E++ P+F Sbjct: 242 CQDLISRIFVANPATRITI-----PEIRNHPWF 269 >3I6U-A nrPDB Length = 419 Score = 95.5 bits (236), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 62/217 (28%), Positives = 115/217 (52%), Gaps = 9/217 (4%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL--ALNERIMLSLV 246 +++ + + +G G GEV + T K A++ + K++ + ALN + ++ Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + P I+ + F D +L+LM GG+L + + EA + Y +++L ++ Sbjct: 195 KKLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 253 Query: 307 HMHNRFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKKPHASV-GTHGYMAPEVL 362 ++H +++RDLKP N+LL +E ++I+D G + + ++ GT Y+APEVL Sbjct: 254 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 313 Query: 363 -QKGVA-YDSSADWFSLGCMLFKLLRGHSPFRQHKTK 397 G A Y+ + D +SLG +LF L G+ PF +H+T+ Sbjct: 314 VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQ 350 >2F57-A nrPDB Length = 317 Score = 94.4 bits (233), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 72/260 (27%), Positives = 127/260 (48%), Gaps = 15/260 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G G V + TGK A+K +D ++ +Q L NE +++ + +V Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMD---LRKQQRRELLFNEVVIMRDYHHDN---VVD 106 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 M ++ D+L +++ + GG L + H +E + ++ L ++HN+ V++R Sbjct: 107 MYSSYLVGDELWVVMEFLEGGAL-TDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHR 165 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLQKGVAYDSSADW 374 D+K +ILL G +++SD G SK+ P + VGT +MAPEV+ + + Y + D Sbjct: 166 DIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISR-LPYGTEVDI 224 Query: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVN 434 +SLG M+ +++ G P+ R +L V+ S LR L+ +L R+ + Sbjct: 225 WSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPS 284 Query: 435 RRLGCLGRGAQEVKESPFFR 454 +R AQE+ PF + Sbjct: 285 QR-----ATAQELLGHPFLK 299 >3ZUT-A nrPDB Length = 362 Score = 94.4 bits (233), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 86/309 (27%), Positives = 131/309 (42%), Gaps = 43/309 (13%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G FG R + ++ A+K +++ GE + N + + + P IV Sbjct: 27 IGSGNFGVARLMRDKQSNELVAVKYIER-------GEKIDENVKREIINHRSLRHPNIVR 79 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 TP L+ +++ +GG+L + G FSE + RF+ ++I G+ + H V +R Sbjct: 80 FKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHR 139 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKK-------PHASVGTHGYMAPEVLQKGVAYD 369 DLK N LLD R+ C F K P ++VGT Y+APEVL K Sbjct: 140 DLKLENTLLDGSPAPRLK----ICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 Query: 370 SSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAVELPD--SFSPELRSLLE 426 AD +S G L+ +L G PF + K+ + L + +PD SPE R L+ Sbjct: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 Query: 427 GLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIG 486 + D +R+ P R+ +W FL+ P L+ D Sbjct: 256 RIFVADPAKRISI-----------PEIRNHEW---FLKNLPADLM--------NDNTMTT 293 Query: 487 SFDEEDTKG 495 FDE D G Sbjct: 294 QFDESDQPG 302 >6FD3-A nrPDB Length = 300 Score = 94.0 bits (232), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 70/260 (26%), Positives = 124/260 (47%), Gaps = 15/260 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG+G G VY TG+ A+K ++ ++ K+ L +NE +++ P IV Sbjct: 30 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEILVMR---ENKNPNIVN 83 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 ++ D+L +++ + GG L +++ E + E + L+ +H+ V++R Sbjct: 84 YLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIHR 142 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKKPHAS--VGTHGYMAPEVLQKGVAYDSSADW 374 D+K NILL G V+++D G + ++ S VGT +MAPEV+ + AY D Sbjct: 143 DIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRK-AYGPKVDI 201 Query: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVN 434 +SLG M +++ G P+ + T ++ P+ S R L L+ DV+ Sbjct: 202 WSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVD 261 Query: 435 RRLGCLGRGAQEVKESPFFR 454 RR A+E+ + PF + Sbjct: 262 RR-----GSAKELLQHPFLK 276 >6HXF-B nrPDB Length = 302 Score = 94.0 bits (232), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 70/275 (25%), Positives = 131/275 (47%), Gaps = 34/275 (12%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G FG+VY + +TG + A K ++ K E + + + +++T D P+IV Sbjct: 27 LGDGAFGKVYKAKNKETGALAAAKVIETK------SEEELEDYIVEIEILATCDHPYIVK 80 Query: 257 MSYAFHTPDKLSFILDLMNGGDLH-YHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 + A++ KL +++ GG + L +E ++ +++ L +H++ +++ Sbjct: 81 LLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIH 140 Query: 316 RDLKPANILLDEHGHVRISDLGLACDFSK--KKPHASVGTHGYMAPEVL----QKGVAYD 369 RDLK N+L+ G +R++D G++ K +K + +GT +MAPEV+ K YD Sbjct: 141 RDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYD 200 Query: 370 SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE--------LPDSFSPEL 421 AD +SLG L ++ + P HE++ M + + + P +S E Sbjct: 201 YKADIWSLGITLIEMAQIEPPH--------HELNPMRVLLKIAKSDPPTLLTPSKWSVEF 252 Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 R L+ L ++ R A ++ E PF S+ Sbjct: 253 RDFLKIALDKNPETR-----PSAAQLLEHPFVSSI 282 >3UC3-A nrPDB Length = 361 Score = 93.2 bits (230), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 80/297 (26%), Positives = 129/297 (43%), Gaps = 38/297 (12%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G FG R T ++ A+K +++ + + +N R + P IV Sbjct: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHRSLRH-------PNIVR 80 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 TP L+ I++ +GG+L+ + G FSE + RF+ +++ G+ + H+ + +R Sbjct: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKK-------PHASVGTHGYMAPEVLQKGVAYD 369 DLK N LLD R+ CDF K P ++VGT Y+APEVL + Sbjct: 141 DLKLENTLLDGSPAPRLK----ICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 Query: 370 SSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAVELPDS--FSPELRSLLE 426 AD +S G L+ +L G PF + +D + + L++ +PD SPE L+ Sbjct: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLIS 256 Query: 427 GLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAF 483 + D R+ P ++ W FL+ P L+ E N F Sbjct: 257 RIFVADPATRISI-----------PEIKTHSW---FLKNLPADLM---NESNTGSQF 296 >4KS7-A nrPDB Length = 292 Score = 92.8 bits (229), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 74/261 (28%), Positives = 129/261 (49%), Gaps = 19/261 (7%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G G V R+ +G+ A+K +D ++ +Q L NE +++ + +V Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRK---QQRRELLFNEVVIMRDYQHFN---VVE 84 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 M ++ ++L +++ + GG L +SQ +E + ++ L ++H + V++R Sbjct: 85 MYKSYLVGEELWVLMEFLQGGALTDIVSQVR-LNEEQIATVCEAVLQALAYLHAQGVIHR 143 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLQKGVAYDSSADW 374 D+K +ILL G V++SD G SK P + VGT +MAPEV+ + + Y + D Sbjct: 144 DIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL-YATEVDI 202 Query: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS--FSPELRSLLEGLLQRD 432 +SLG M+ +++ G P+ + R+ + +L +S SP LR LE +L RD Sbjct: 203 WSLGIMVIEMVDGEPPY--FSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRD 260 Query: 433 VNRRLGCLGRGAQEVKESPFF 453 R AQE+ + PF Sbjct: 261 PQER-----ATAQELLDHPFL 276 >4PDS-A nrPDB Length = 347 Score = 92.8 bits (229), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 75/269 (27%), Positives = 133/269 (49%), Gaps = 32/269 (11%) Query: 190 DFSV-HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 DFS+ ++G+G F V + TGK +++K + K+++ G + L ++ Sbjct: 31 DFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVI---GNMDGVTRE--LEVLQK 85 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 + P IV + + + +++ ++GGDL ++ HG E R + +I+ ++++ Sbjct: 86 LNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYI 145 Query: 309 HNRFVVYRDLKPANILL--DEHGHVRISDLGLACDFSKKKPHASV-----GTHGYMAPEV 361 H+ + +RDLKP NIL+ D+ V+I+ GLA K + + S GT Y+APEV Sbjct: 146 HSMGISHRDLKPDNILIEQDDPVLVKITAFGLA----KVQGNGSFMKTFCGTLAYVAPEV 201 Query: 362 LQ---KGVA---------YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK--HEIDRMTL 407 ++ V+ Y S D +S+GC+++ +L GH PF T+D+ +I R + Sbjct: 202 IRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF-SGSTQDQLYKQIGRGSY 260 Query: 408 TMAVELPDSFSPELRSLLEGLLQRDVNRR 436 S E R ++ LLQ D N R Sbjct: 261 HEGPLKDFRISEEARDFIDSLLQVDPNNR 289 >3DAK-A nrPDB Length = 290 Score = 92.8 bits (229), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 73/275 (26%), Positives = 134/275 (48%), Gaps = 31/275 (11%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 + +D+ + +IG G V A + A+K RI +++ +T +++E ++ + Sbjct: 7 INRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIK-----RINLEKCQT-SMDE-LLKEI 59 Query: 246 VSTGDC--PFIVCMSYAFHTPDKLSFILDLMNGG---DLHYHL-----SQHGVFSEADMR 295 + C P IV +F D+L ++ L++GG D+ H+ + GV E+ + Sbjct: 60 QAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIA 119 Query: 296 FYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC------DFSKKKPHA 349 E++ GLE++H ++RD+K NILL E G V+I+D G++ D ++ K Sbjct: 120 TILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRK 179 Query: 350 S-VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD----KHEIDR 404 + VGT +MAPEV+++ YD AD +S G +L G +P+ ++ + D Sbjct: 180 TFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDP 239 Query: 405 MTLTMAV---ELPDSFSPELRSLLEGLLQRDVNRR 436 +L V E+ + R ++ LQ+D +R Sbjct: 240 PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKR 274 >4D2V-A nrPDB Length = 356 Score = 92.4 bits (228), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 69/252 (27%), Positives = 118/252 (46%), Gaps = 15/252 (5%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + +H IG GGF +V TG+M A+K +DK + G L RI + + + Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTL----GSDLP---RIKTEIEALKN 83 Query: 251 C--PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 I + + T +K+ +L+ GG+L ++ SE + R +I+ + ++ Sbjct: 84 LRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYV 143 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH---ASVGTHGYMAPEVLQKG 365 H++ +RDLKP N+L DE+ +++ D GL K + A G Y APE++Q Sbjct: 144 HSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGK 203 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 S AD +S+G +L+ L+ G PF + + ++P SP LL Sbjct: 204 SYLGSEADVWSMGILLYVLMCGFLPFDDDTAA---ALVAKIMRGKYDVPKWLSPSSILLL 260 Query: 426 EGLLQRDVNRRL 437 + +LQ D +R+ Sbjct: 261 QQMLQVDPKKRI 272 >5EZV-A nrPDB Length = 560 Score = 92.4 bits (228), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 78/290 (26%), Positives = 133/290 (45%), Gaps = 27/290 (9%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G FG+V TG A+K L++++I+ E L L P I+ Sbjct: 36 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH---PHIIK 92 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + TP +++ ++GG+L ++ +HG E + R +I+ +++ H VV+R Sbjct: 93 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 152 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGVAYDSSADWF 375 DLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ + D + Sbjct: 153 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 212 Query: 376 SLGCMLFKLLRGHSPFRQHKTKDKH--EIDRMTLTMAVELPDSFSPELRSLLEGLLQRDV 433 S G +L+ LL G PF D+H + + +P+ + + +LL +LQ D Sbjct: 213 SCGVILYALLCGTLPF-----DDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDP 267 Query: 434 NRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP--PRGEVNAAD 481 +R ++++E +F+ Q P L P P + N D Sbjct: 268 LKRATI-----KDIREHEWFK---------QDLPSYLFPEDPSYDANVID 303 >3H4J-B nrPDB Length = 336 Score = 92.0 bits (227), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 67/264 (25%), Positives = 125/264 (47%), Gaps = 13/264 (4%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + +G G FG+V T + A+K + ++ +K E L L+ Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRH-- 68 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P I+ + TP + +++ GG+L ++ + +E + R + +II +E+ H Sbjct: 69 -PHIIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHR 126 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGVAYD 369 +V+RDLKP N+LLD++ +V+I+D GL+ + S G+ Y APEV+ + Sbjct: 127 HKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAG 186 Query: 370 SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLL 429 D +S G +L+ +L G PF + + + + +PD SP +SL+ ++ Sbjct: 187 PEVDVWSCGIVLYVMLVGRLPFDDEFIPN---LFKKVNSCVYVMPDFLSPGAQSLIRRMI 243 Query: 430 QRDVNRRLGCLGRGAQEVKESPFF 453 D +R+ QE++ P+F Sbjct: 244 VADPMQRITI-----QEIRRDPWF 262 >4CFF-A nrPDB Length = 571 Score = 92.0 bits (227), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 80/290 (27%), Positives = 132/290 (45%), Gaps = 27/290 (9%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G FG+V TG A+K L++++I+ E L L P I+ Sbjct: 41 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH---PHIIK 97 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + TP +++ ++GG+L ++ +HG E + R +I+ +++ H VV+R Sbjct: 98 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 157 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGVAYDSSADWF 375 DLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ + D + Sbjct: 158 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 217 Query: 376 SLGCMLFKLLRGHSPFRQHKTKDKH--EIDRMTLTMAVELPDSFSPELRSLLEGLLQRDV 433 S G +L+ LL G PF D+H + + +P+ + + +LL +LQ D Sbjct: 218 SCGVILYALLCGTLPF-----DDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDP 272 Query: 434 NRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP--PRGEVNAAD 481 +R +K+ R +W F Q P L P P + N D Sbjct: 273 LKR--------ATIKD---IREHEW---FKQDLPSYLFPEDPSYDANVID 308 >4I6B-A nrPDB Length = 308 Score = 91.7 bits (226), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 61/252 (24%), Positives = 122/252 (48%), Gaps = 9/252 (3%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 T +S + +G+GGF + Y K+YA K + R+ K + +++ I L + Sbjct: 26 TGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVS-KPHQREKIDKEIELHRI 84 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 +V + F + + +L+ + + + L V +E ++R+Y +I+ GL+ Sbjct: 85 LHHK--HVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLK 142 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVGTHGYMAPEVLQK 364 ++H + +++RDLK N ++E +++ D GLA + + GT Y++PEVL K Sbjct: 143 YLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNK 202 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 424 + + +D ++LGC+++ +L G PF +T + E R +P S + L Sbjct: 203 Q-GHGAESDIWALGCVMYTMLLGRPPF---ETTNLKETYRSIREARYTMPSSLLAPAKHL 258 Query: 425 LEGLLQRDVNRR 436 + +L ++ R Sbjct: 259 IASMLSKNPEDR 270 >4AF3-A nrPDB Length = 292 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 69/256 (26%), Positives = 128/256 (50%), Gaps = 7/256 (2%) Query: 182 LNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 241 L H T++DF + R +G+G FG VY R+ + + A+K L K +I+ K+G L I Sbjct: 16 LTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIE-KEGVEHQLRREI 74 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 + + P I+ + F+ ++ IL+ G+L+ L + F E E+ Sbjct: 75 EIQ--AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEEL 132 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEV 361 L + H + V++RD+KP N+LL G ++I+D G + + GT Y+ PE+ Sbjct: 133 ADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEM 192 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 ++ G ++ D + +G + ++LL G+ PF ++ +E R + + ++ P S Sbjct: 193 IE-GRMHNEKVDLWCIGVLCYELLVGNPPF---ESASHNETYRRIVKVDLKFPASVPTGA 248 Query: 422 RSLLEGLLQRDVNRRL 437 + L+ LL+ + + RL Sbjct: 249 QDLISKLLRHNPSERL 264 >4XBR-A nrPDB Length = 366 Score = 90.9 bits (224), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 70/259 (27%), Positives = 124/259 (47%), Gaps = 15/259 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G G V +GK+ A+K +D ++ +Q L NE +++ + +V Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDYQHEN---VVE 155 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 M ++ D+L +++ + GG L + H +E + ++ L +H + V++R Sbjct: 156 MYNSYLVGDELWVVMEFLEGGAL-TDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHR 214 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKKPH--ASVGTHGYMAPEVLQKGVAYDSSADW 374 D+K +ILL G V++SD G SK+ P + VGT +MAPE++ + + Y D Sbjct: 215 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISR-LPYGPEVDI 273 Query: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVN 434 +SLG M+ +++ G P+ ++ R L ++ SP L+ L+ LL RD Sbjct: 274 WSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPA 333 Query: 435 RRLGCLGRGAQEVKESPFF 453 +R A E+ + PF Sbjct: 334 QRA-----TAAELLKHPFL 347 >4FIE-A nrPDB Length = 423 Score = 90.9 bits (224), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 70/259 (27%), Positives = 124/259 (47%), Gaps = 15/259 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G G V +GK+ A+K +D ++ +Q L NE +++ + +V Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDYQHEN---VVE 212 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 M ++ D+L +++ + GG L + H +E + ++ L +H + V++R Sbjct: 213 MYNSYLVGDELWVVMEFLEGGAL-TDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHR 271 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKKPH--ASVGTHGYMAPEVLQKGVAYDSSADW 374 D+K +ILL G V++SD G SK+ P + VGT +MAPE++ + + Y D Sbjct: 272 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISR-LPYGPEVDI 330 Query: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVN 434 +SLG M+ +++ G P+ ++ R L ++ SP L+ L+ LL RD Sbjct: 331 WSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPA 390 Query: 435 RRLGCLGRGAQEVKESPFF 453 +R A E+ + PF Sbjct: 391 QRA-----TAAELLKHPFL 404 >2Q0N-A nrPDB Length = 301 Score = 90.9 bits (224), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 70/259 (27%), Positives = 124/259 (47%), Gaps = 15/259 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G G V +GK+ A+K +D ++ +Q L NE +++ + +V Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDYQHEN---VVE 90 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 M ++ D+L +++ + GG L + H +E + ++ L +H + V++R Sbjct: 91 MYNSYLVGDELWVVMEFLEGGAL-TDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHR 149 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKKPH--ASVGTHGYMAPEVLQKGVAYDSSADW 374 D+K +ILL G V++SD G SK+ P + VGT +MAPE++ + + Y D Sbjct: 150 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISR-LPYGPEVDI 208 Query: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVN 434 +SLG M+ +++ G P+ ++ R L ++ SP L+ L+ LL RD Sbjct: 209 WSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPA 268 Query: 435 RRLGCLGRGAQEVKESPFF 453 +R A E+ + PF Sbjct: 269 QRA-----TAAELLKHPFL 282 >4CQG-A nrPDB Length = 331 Score = 90.9 bits (224), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 68/251 (27%), Positives = 119/251 (47%), Gaps = 11/251 (4%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + ++ IG GGF +V TG+M A+K +DK + G L + + +L S Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNAL----GSDLPRVKTEIDALKSLRH 66 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 I + + T +K+ +L+ GG+L ++ SE + R +I+ + ++H+ Sbjct: 67 -QHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHS 125 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH---ASVGTHGYMAPEVLQKGVA 367 + +RDLKP N+L DE+ +++ D GL K + G+ Y APE++Q Sbjct: 126 QGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSY 185 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEG 427 S AD +S+G +L+ L+ G PF + + + E+P SP LL+ Sbjct: 186 LGSEADVWSMGILLYVLMCGFLPFDDDNVM---ALYKKIMRGKYEVPKWLSPSSILLLQQ 242 Query: 428 LLQRDVNRRLG 438 +LQ D +R+ Sbjct: 243 MLQVDPKKRIS 253 >4JDH-A nrPDB Length = 346 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 70/259 (27%), Positives = 124/259 (47%), Gaps = 15/259 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G G V +GK+ A+K +D ++ +Q L NE +++ + +V Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDYQHEN---VVE 135 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 M ++ D+L +++ + GG L + H +E + ++ L +H + V++R Sbjct: 136 MYNSYLVGDELWVVMEFLEGGAL-TDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHR 194 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKKPH--ASVGTHGYMAPEVLQKGVAYDSSADW 374 D+K +ILL G V++SD G SK+ P + VGT +MAPE++ + + Y D Sbjct: 195 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISR-LPYGPEVDI 253 Query: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVN 434 +SLG M+ +++ G P+ ++ R L ++ SP L+ L+ LL RD Sbjct: 254 WSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPA 313 Query: 435 RRLGCLGRGAQEVKESPFF 453 +R A E+ + PF Sbjct: 314 QRA-----TAAELLKHPFL 327 >5DBX-A nrPDB Length = 328 Score = 90.1 bits (222), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 68/236 (28%), Positives = 121/236 (51%), Gaps = 26/236 (11%) Query: 225 KRIKMKQGETLALNERIMLSLVSTGDC--PFIVCMSYAFHTPDKLSFILDLMNGGDL--- 279 KRI +++ +T +++E ++ + + C P +V +F D+L ++ L++GG + Sbjct: 42 KRINLEKCQT-SMDE-LLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDI 99 Query: 280 -HYHLS----QHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRIS 334 Y ++ ++GV EA + E++ GL+++H ++RDLK NILL E G V+I+ Sbjct: 100 IKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIA 159 Query: 335 DLGLAC------DFSKKKPHAS-VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRG 387 D G++ D ++ K VGT +MAPEV+++ YD AD +S G +L G Sbjct: 160 DFGVSAFLATGGDVTRNKVRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATG 219 Query: 388 HSPFRQHKTKD----KHEIDRMTLTMAV---ELPDSFSPELRSLLEGLLQRDVNRR 436 +P+ ++ + D TL V E+ + R LL LQ+D ++R Sbjct: 220 AAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKR 275 >3Q53-A nrPDB Length = 306 Score = 90.1 bits (222), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 65/242 (26%), Positives = 115/242 (47%), Gaps = 10/242 (4%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG+G G VY TG+ A++ ++ ++ K+ L +NE +++ P IV Sbjct: 29 IGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKE---LIINEILVMR---ENKNPNIVN 82 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 ++ D+L +++ + GG L +++ E + E + LE +H+ V++R Sbjct: 83 YLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALEFLHSNQVIHR 141 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKKPHAS--VGTHGYMAPEVLQKGVAYDSSADW 374 D+K NILL G V+++D G + ++ S VGT +MAPEV+ + AY D Sbjct: 142 DIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRK-AYGPKVDI 200 Query: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVN 434 +SLG M +++ G P+ + T ++ P+ S R L L+ DV Sbjct: 201 WSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVE 260 Query: 435 RR 436 +R Sbjct: 261 KR 262 >2YZA-A nrPDB Length = 276 Score = 90.1 bits (222), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 69/243 (28%), Positives = 117/243 (48%), Gaps = 11/243 (4%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G FG+V TG A+K L++++I+ E L L P I+ Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH---PHIIK 75 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + TP +++ ++GG+L ++ +HG E + R +I+ +++ H VV+R Sbjct: 76 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 135 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGVAYDSSADWF 375 DLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ + D + Sbjct: 136 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAGPEVDIW 195 Query: 376 SLGCMLFKLLRGHSPFRQHKTKDKH--EIDRMTLTMAVELPDSFSPELRSLLEGLLQRDV 433 S G +L+ LL G PF D+H + + +P+ + + +LL +LQ D Sbjct: 196 SCGVILYALLCGTLPF-----DDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDP 250 Query: 434 NRR 436 +R Sbjct: 251 LKR 253 >6QAU-A nrPDB Length = 280 Score = 89.4 bits (220), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 73/259 (28%), Positives = 126/259 (48%), Gaps = 17/259 (6%) Query: 190 DFSVHRIIGRGGFGEVY-GCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 ++S ++G G F V+ G + T A+K ++KK + Q + L + I ++ Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ---ILLGKEI--KILKE 66 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 IV + P+ + +++ NGGDL +L G SE +R + +I + + Sbjct: 67 LQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRIL 126 Query: 309 HNRFVVYRDLKPANILLDEHG---------HVRISDLGLACDFSKKKPHASV-GTHGYMA 358 H++ +++RDLKP NILL ++I+D G A A + G+ YMA Sbjct: 127 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMA 186 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS 418 PEV+ YD+ AD +S+G ++++ L G PF+ + +D ++ +P S Sbjct: 187 PEVIMSQ-HYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 245 Query: 419 PELRSLLEGLLQRDVNRRL 437 P L +LL GLLQR+ R+ Sbjct: 246 PYLANLLLGLLQRNQKDRM 264 >5B2L-A nrPDB Length = 324 Score = 89.0 bits (219), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 73/263 (27%), Positives = 120/263 (45%), Gaps = 25/263 (9%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL-- 245 +ND +G G G+V+ R TG + A+K +M++ N+RI++ L Sbjct: 16 INDLENLGEMGSGTCGQVWKMRFRKTGHVIAVK-------QMRRSGNKEENKRILMDLDV 68 Query: 246 -VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 + + DCP+IV F T + ++LM G E + I+ Sbjct: 69 VLKSHDCPYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKA 128 Query: 305 LEHMHNRF-VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA-SVGTHGYMAPEVL 362 L ++ + V++RD+KP+NILLDE G +++ D G++ K S G YMAPE + Sbjct: 129 LYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERI 188 Query: 363 Q----KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP---- 414 YD AD +SLG L +L G P++ KT + + +T + E P Sbjct: 189 DPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKT----DFEVLTKVLQEEPPLLPG 244 Query: 415 -DSFSPELRSLLEGLLQRDVNRR 436 FS + +S ++ L +D +R Sbjct: 245 HMGFSGDFQSFVKDCLTKDHRKR 267 >1UA2-A nrPDB Length = 346 Score = 88.2 bits (217), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 63/194 (32%), Positives = 103/194 (53%), Gaps = 9/194 (4%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLD-KKRIKMKQG-ETLALNERIMLSLVSTGDCPFI 254 +G G F VY R +T ++ A+K + R + K G AL E +L +S P I Sbjct: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH---PNI 74 Query: 255 VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIILGLEHMHNRFV 313 + + AF +S + D M DL + + V + + ++ Y + GLE++H ++ Sbjct: 75 IGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 Query: 314 VYRDLKPANILLDEHGHVRISDLGLACDF-SKKKPHA-SVGTHGYMAPEVLQKGVAYDSS 371 ++RDLKP N+LLDE+G ++++D GLA F S + + V T Y APE+L Y Sbjct: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVG 193 Query: 372 ADWFSLGCMLFKLL 385 D +++GC+L +LL Sbjct: 194 VDMWAVGCILAELL 207 >2YAB-A nrPDB Length = 361 Score = 88.2 bits (217), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 73/279 (26%), Positives = 132/279 (47%), Gaps = 20/279 (7%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKM-KQGETLALNERIMLSLVSTGDCPFIV 255 +G G F V CR+ TG YA K + K++ + ++G ER +S++ P I+ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIER-EVSILRQVLHPNII 78 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 + + + IL+L++GG+L L+Q SE + + +I+ G+ ++H + + + Sbjct: 79 TLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAH 138 Query: 316 RDLKPANILLDEHG----HVRISDLGLACDFSKKKPHASV-GTHGYMAPEVLQKGVAYDS 370 DLKP NI+L + H+++ D GLA + ++ GT ++APE+ V Y+ Sbjct: 139 FDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI----VNYEP 194 Query: 371 ---SADWFSLGCMLFKLLRGHSPFR-QHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLE 426 AD +S+G + + LL G SPF K + I ++ E S + + Sbjct: 195 LGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIR 254 Query: 427 GLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQK 465 LL ++ +RL QE P+ +D Q +++ Sbjct: 255 KLLVKETRKRLTI-----QEALRHPWITPVDTQQAMVRR 288 >6CCF-A nrPDB Length = 290 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 75/280 (26%), Positives = 131/280 (46%), Gaps = 28/280 (10%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG------------- 232 + +N + + IG+G +G V + YAMK L KK++ + G Sbjct: 2 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 61 Query: 233 -----ETLALNERIM--LSLVSTGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHL 283 + L ER+ ++++ D +V + P D L + DL+ G + + Sbjct: 62 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPV-MEV 120 Query: 284 SQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS 343 FSE R Y ++ILGLE++H + +V+RD+KP+N+LL + GHV+I+D G++ F Sbjct: 121 PCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 180 Query: 344 KKKPH--ASVGTHGYMAPEVLQ-KGVAYDSSA-DWFSLGCMLFKLLRGHSPFRQHKTKDK 399 ++ GT +MAPE + G ++ A D ++ G L+ + G PF Sbjct: 181 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 240 Query: 400 HEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGC 439 H + + E P+ S EL+ L+ +L ++ R+G Sbjct: 241 HRKIKNEPVVFPEEPE-ISEELKDLILKMLDKNPETRIGV 279 >1PHK-A nrPDB Length = 298 Score = 87.4 bits (215), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 75/288 (26%), Positives = 127/288 (44%), Gaps = 26/288 (9%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL------A 236 + H ++ I+GRG V C T K YA+K +D E + Sbjct: 11 STHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREAT 70 Query: 237 LNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRF 296 L E +L VS P I+ + + T + DLM G+L +L++ SE + R Sbjct: 71 LKEVDILRKVSGH--PNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRK 128 Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASVGTHG 355 ++ + +H +V+RDLKP NILLD+ +++++D G +C +K GT Sbjct: 129 IMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPS 188 Query: 356 YMAPEVLQKGV-----AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA 410 Y+APE+++ + Y D +S G +++ LL G PF K + + RM ++ Sbjct: 189 YLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRK---QMLMLRMIMSGN 245 Query: 411 VELP----DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 + D +S ++ L+ L +R A+E PFF+ Sbjct: 246 YQFGSPEWDDYSDTVKDLVSRFLVVQPQKRY-----TAEEALAHPFFQ 288 >4JG6-A nrPDB Length = 355 Score = 87.4 bits (215), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 75/265 (28%), Positives = 125/265 (47%), Gaps = 32/265 (12%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDK-KRIKMKQGETLALNERIMLSLVS 247 + + V IG G + C T +A+K +DK KR ++ E L + Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEIL----------LR 84 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 G P I+ + + + + +LM GG+L + + FSE + I +E+ Sbjct: 85 YGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEY 144 Query: 308 MHNRFVVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKKPHASVG-------THGY 356 +H + VV+RDLKP+NIL +DE G+ +RI D G A K+ A G T + Sbjct: 145 LHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFA-----KQLRAENGLLMTPCYTANF 199 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE----IDRMTLTMAVE 412 +APEVL++ YD++ D +SLG +L+ +L G++PF E I +++ Sbjct: 200 VAPEVLERQ-GYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGG 258 Query: 413 LPDSFSPELRSLLEGLLQRDVNRRL 437 +S S + L+ +L D ++RL Sbjct: 259 YWNSVSDTAKDLVSKMLHVDPHQRL 283 >3MN3-A nrPDB Length = 271 Score = 87.4 bits (215), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 76/290 (26%), Positives = 133/290 (45%), Gaps = 28/290 (9%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + ++ + + +G G FG+V TG+ A+K ++KK + + E L L+ Sbjct: 3 IGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLR 62 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 P I+ + + D++ +++ G +L ++ Q SE + R + +II +E+ Sbjct: 63 H---PHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEY 118 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGV 366 H +V+RDLKP N+LLDEH +V+I+D GL+ + S G+ Y APEV+ + Sbjct: 119 CHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKL 178 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA---VELPDSFSPELRS 423 D +S G +L+ +L PF D I + ++ LP SP Sbjct: 179 YAGPEVDVWSCGVILYVMLCRRLPF------DDESIPVLFKNISNGVYTLPKFLSPGAAG 232 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPP 473 L++ +L + R+ E+ + DW V L +Y L+PP Sbjct: 233 LIKRMLIVNPLNRISI-----HEIMQD------DWFKVDLPEY---LLPP 268 >2UV2-A nrPDB Length = 325 Score = 87.0 bits (214), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 61/255 (23%), Positives = 122/255 (47%), Gaps = 29/255 (11%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G FG+VY + +T + A K +D K E + + + ++++ D P IV Sbjct: 45 LGDGAFGKVYKAQNKETSVLAAAKVIDTK------SEEELEDYMVEIDILASCDHPNIVK 98 Query: 257 MSYAFHTPDKLSFILDLMNGGDLH-YHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 + AF+ + L +++ GG + L +E+ ++ + + L ++H+ +++ Sbjct: 99 LLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIH 158 Query: 316 RDLKPANILLDEHGHVRISDLGLACDFSK--KKPHASVGTHGYMAPEVL----QKGVAYD 369 RDLK NIL G ++++D G++ ++ ++ + +GT +MAPEV+ K YD Sbjct: 159 RDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYD 218 Query: 370 SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV--------ELPDSFSPEL 421 AD +SLG L ++ P HE++ M + + + P +S Sbjct: 219 YKADVWSLGITLIEMAEIEPP--------HHELNPMRVLLKIAKSEPPTLAQPSRWSSNF 270 Query: 422 RSLLEGLLQRDVNRR 436 + L+ L+++V+ R Sbjct: 271 KDFLKKCLEKNVDAR 285 >5KKR-C nrPDB Length = 395 Score = 86.3 bits (212), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 107/213 (50%), Gaps = 11/213 (5%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +DF +G G G V+ +G + A K + +++K A+ +I+ L Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI---HLEIKP----AIRNQIIRELQVL 120 Query: 249 GDC--PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 +C P+IV AF++ ++S ++ M+GG L L + G E + + +I GL Sbjct: 121 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 180 Query: 307 HMHNRF-VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKG 365 ++ + +++RD+KP+NIL++ G +++ D G++ ++ VGT YM+PE LQ G Sbjct: 181 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ-G 239 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 Y +D +S+G L ++ G P K+ Sbjct: 240 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 272 >4WNO-A nrPDB Length = 287 Score = 85.5 bits (210), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 65/220 (29%), Positives = 108/220 (49%), Gaps = 17/220 (7%) Query: 190 DFSVHRIIGRGGFGEVY-GCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +FS +IG G F V+ G +A A+KC++KK + Q TL E +L + Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQ--TLLGKEIKILKELKH 76 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 + IV + + + +++ NGGDL +L SE +R + +I + + Sbjct: 77 EN---IVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLL 133 Query: 309 HNRFVVYRDLKPANILLDEHG---------HVRISDLGLACDFSKKKPHASV-GTHGYMA 358 H++ +++RDLKP NILL V+I+D G A A++ G+ YMA Sbjct: 134 HSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMA 193 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 PEV+ YD AD +S+G ++++ L G +PF+ +D Sbjct: 194 PEVIMS-QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD 232 >3EQC-A nrPDB Length = 360 Score = 85.5 bits (210), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 105/206 (50%), Gaps = 11/206 (5%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +DF +G G G V+ +G + A K + +++K A+ +I+ L Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI---HLEIKP----AIRNQIIRELQVL 85 Query: 249 GDC--PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 +C P+IV AF++ ++S ++ M+GG L L + G E + + +I GL Sbjct: 86 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 145 Query: 307 HMHNRF-VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKG 365 ++ + +++RD+KP+NIL++ G +++ D G++ ++ VGT YM+PE LQ G Sbjct: 146 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ-G 204 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPF 391 Y +D +S+G L ++ G P Sbjct: 205 THYSVQSDIWSMGLSLVEMAVGRYPI 230 >3LM0-A nrPDB Length = 327 Score = 85.1 bits (209), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 71/256 (27%), Positives = 125/256 (48%), Gaps = 29/256 (11%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +GRG F V C TG+ YA K L K+R + + L+E +L L + CP ++ Sbjct: 37 LGRGKFAVVRQCISKSTGQEYAAKFLKKRR-RGQDCRAEILHEIAVLELAKS--CPRVIN 93 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHY----HLSQHGVFSEADMRFYAAEIILGLEHMHNRF 312 + + ++ IL+ GG++ L++ + SE D+ +I+ G+ ++H Sbjct: 94 LHEVYENTSEIILILEYAAGGEIFSLCLPELAE--MVSENDVIRLIKQILEGVYYLHQNN 151 Query: 313 VVYRDLKPANILLDE---HGHVRISDLGLACDFSKKKPHAS-----VGTHGYMAPEVLQK 364 +V+ DLKP NILL G ++I D G+ S+K HA +GT Y+APE+L Sbjct: 152 IVHLDLKPQNILLSSIYPLGDIKIVDFGM----SRKIGHACELREIMGTPEYLAPEILN- 206 Query: 365 GVAYD---SSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFSPE 420 YD ++ D +++G + + LL SPF ++ + I ++ + + E S S Sbjct: 207 ---YDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQL 263 Query: 421 LRSLLEGLLQRDVNRR 436 ++ LL ++ +R Sbjct: 264 ATDFIQSLLVKNPEKR 279 >3COM-A nrPDB Length = 314 Score = 85.1 bits (209), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 61/237 (25%), Positives = 114/237 (48%), Gaps = 19/237 (8%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F V +G G +G VY +TG++ A+K ++ ++ + E +S++ D Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIK-----QVPVESDLQEIIKE---ISIMQQCD 82 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADMRFYAAEIILGLEHMH 309 P +V ++ L +++ G + + ++ +E ++ + GLE++H Sbjct: 83 SPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLH 142 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVA 367 ++RD+K NILL+ GH +++D G+A + K + +GT +MAPEV+Q+ + Sbjct: 143 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-IG 201 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSF-SPELRS 423 Y+ AD +SLG ++ G P+ D H + R + P +F PEL S Sbjct: 202 YNCVADIWSLGITAIEMAEGKPPY-----ADIHPM-RAIFMIPTNPPPTFRKPELWS 252 >6E2O-A nrPDB Length = 295 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 66/250 (26%), Positives = 121/250 (48%), Gaps = 17/250 (6%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG--ETLALNERIMLSLVSTGDCPF 253 ++G+G +G VY R A+K + ++ + Q E +AL++ + Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHK--------N 80 Query: 254 IVCMSYAFHTPDKLSFILDLMNGGDLHYHL-SQHGVF--SEADMRFYAAEIILGLEHMHN 310 IV +F + ++ + GG L L S+ G +E + FY +I+ GL+++H+ Sbjct: 81 IVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHD 140 Query: 311 RFVVYRDLKPANILLDEH-GHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLQKGV- 366 +V+RD+K N+L++ + G ++ISD G + + P GT YMAPE++ KG Sbjct: 141 NQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPR 200 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLE 426 Y +AD +SLGC + ++ G PF + + E+P+S S E ++ + Sbjct: 201 GYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFIL 260 Query: 427 GLLQRDVNRR 436 + D ++R Sbjct: 261 KCFEPDPDKR 270 >1KOA-A nrPDB Length = 491 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 87/333 (26%), Positives = 142/333 (42%), Gaps = 41/333 (12%) Query: 174 FCQWKN-----VELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIK 228 F WK VE+ ++ + +H +G G FG V+ + TG +A K + Sbjct: 31 FDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV------ 84 Query: 229 MKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHG 287 M E+ R + +S P +V + AF +++ I + M+GG+L ++ +H Sbjct: 85 MTPHESDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHN 144 Query: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD--EHGHVRISDLGLACDFSKK 345 SE + Y ++ GL HMH V+ DLKP NI+ +++ D GL K Sbjct: 145 KMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPK 204 Query: 346 KP-HASVGTHGYMAPEVLQ-KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEID 403 + + GT + APEV + K V Y D +S+G + + LL G SPF ++ E Sbjct: 205 QSVKVTTGTAEFAAPEVAEGKPVGY--YTDMWSVGVLSYILLSGLSPF---GGENDDETL 259 Query: 404 RMTLTMAVELPDS----FSPELRSLLEGLLQRDVNRRL--------------GCLGRGAQ 445 R + + DS S + + + LL D N R+ GR +Q Sbjct: 260 RNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQ 319 Query: 446 EVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVN 478 + S + + D +P PL PP G ++ Sbjct: 320 -IPSSRYTKIRDSIKTKYDAWPEPL-PPLGRIS 350 >2X4F-A nrPDB Length = 373 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 107/203 (52%), Gaps = 17/203 (8%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 I+G G FG+V+ C + TG A K + + +K K+ NE +S+++ D ++ Sbjct: 96 ILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEE---VKNE---ISVMNQLDHANLI 149 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEHMHNRFVV 314 + AF + + + +++ ++GG+L + +E D + +I G+ HMH +++ Sbjct: 150 QLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYIL 209 Query: 315 YRDLKPANILL--DEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKGVAYDSS 371 + DLKP NIL + ++I D GLA + ++K + GT ++APEV V YD Sbjct: 210 HLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEV----VNYDFV 265 Query: 372 A---DWFSLGCMLFKLLRGHSPF 391 + D +S+G + + LL G SPF Sbjct: 266 SFPTDMWSVGVIAYMLLSGLSPF 288 >2J90-A nrPDB Length = 304 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 67/251 (26%), Positives = 124/251 (49%), Gaps = 15/251 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKM-KQGETLALNERIMLSLVSTGDCPFIV 255 +G G F V CR+ TGK YA K + K+R+ ++G + ER ++++ P I+ Sbjct: 34 LGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIER-EVNILREIRHPNII 92 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 + F + IL+L++GG+L L++ +E + + +I+ G+ ++H++ + + Sbjct: 93 TLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAH 152 Query: 316 RDLKPANILLDEHG----HVRISDLGLACDFSKKKPHASV-GTHGYMAPEVLQKGVAYDS 370 DLKP NI+L + +++ D G+A ++ GT ++APE+ V Y+ Sbjct: 153 FDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEI----VNYEP 208 Query: 371 ---SADWFSLGCMLFKLLRGHSPF-RQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLE 426 AD +S+G + + LL G SPF + K + I + E + S + + Sbjct: 209 LGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIR 268 Query: 427 GLLQRDVNRRL 437 LL +D RR+ Sbjct: 269 RLLVKDPKRRM 279 >2A27-A nrPDB Length = 321 Score = 84.3 bits (207), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 71/279 (25%), Positives = 132/279 (47%), Gaps = 20/279 (7%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKM-KQGETLALNERIMLSLVSTGDCPFIV 255 +G G F V CR+ TG YA K + K++ + ++G + ER +S++ ++ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIER-EVSILRQVLHHNVI 78 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 + + + IL+L++GG+L L+Q SE + + +I+ G+ ++H + + + Sbjct: 79 TLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAH 138 Query: 316 RDLKPANILLDEHG----HVRISDLGLACDFSKKKPHASV-GTHGYMAPEVLQKGVAYDS 370 DLKP NI+L + H+++ D GLA + ++ GT ++APE+ V Y+ Sbjct: 139 FDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI----VNYEP 194 Query: 371 ---SADWFSLGCMLFKLLRGHSPF-RQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLE 426 AD +S+G + + LL G SPF K + I ++ E S + + Sbjct: 195 LGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIR 254 Query: 427 GLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQK 465 LL ++ +RL QE P+ +D Q +++ Sbjct: 255 KLLVKETRKRLTI-----QEALRHPWITPVDNQQAMVRR 288 >1ZWS-A nrPDB Length = 288 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 71/279 (25%), Positives = 132/279 (47%), Gaps = 20/279 (7%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKM-KQGETLALNERIMLSLVSTGDCPFIV 255 +G G F V CR+ TG YA K + K++ + ++G + ER +S++ ++ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIER-EVSILRQVLHHNVI 78 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 + + + IL+L++GG+L L+Q SE + + +I+ G+ ++H + + + Sbjct: 79 TLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAH 138 Query: 316 RDLKPANILLDEHG----HVRISDLGLACDFSKKKPHASV-GTHGYMAPEVLQKGVAYDS 370 DLKP NI+L + H+++ D GLA + ++ GT ++APE+ V Y+ Sbjct: 139 FDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI----VNYEP 194 Query: 371 ---SADWFSLGCMLFKLLRGHSPF-RQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLE 426 AD +S+G + + LL G SPF K + I ++ E S + + Sbjct: 195 LGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFSHTSELAKDFIR 254 Query: 427 GLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQK 465 LL ++ +RL QE P+ +D Q +++ Sbjct: 255 KLLVKETRKRLTI-----QEALRHPWITPVDNQQAMVRR 288 >3UTO-A nrPDB Length = 573 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 87/333 (26%), Positives = 142/333 (42%), Gaps = 41/333 (12%) Query: 174 FCQWKN-----VELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIK 228 F WK VE+ ++ + +H +G G FG V+ + TG +A K + Sbjct: 137 FDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV------ 190 Query: 229 MKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHG 287 M E+ R + +S P +V + AF +++ I + M+GG+L ++ +H Sbjct: 191 MTPHESDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHN 250 Query: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD--EHGHVRISDLGLACDFSKK 345 SE + Y ++ GL HMH V+ DLKP NI+ +++ D GL K Sbjct: 251 KMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPK 310 Query: 346 KP-HASVGTHGYMAPEVLQ-KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEID 403 + + GT + APEV + K V Y D +S+G + + LL G SPF ++ E Sbjct: 311 QSVKVTTGTAEFAAPEVAEGKPVGY--YTDMWSVGVLSYILLSGLSPF---GGENDDETL 365 Query: 404 RMTLTMAVELPDS----FSPELRSLLEGLLQRDVNRRL--------------GCLGRGAQ 445 R + + DS S + + + LL D N R+ GR +Q Sbjct: 366 RNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQ 425 Query: 446 EVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVN 478 + S + + D +P PL PP G ++ Sbjct: 426 -IPSSRYTKIRDSIKTKYDAWPEPL-PPLGRIS 456 >1KOB-A nrPDB Length = 387 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 68/253 (26%), Positives = 124/253 (49%), Gaps = 26/253 (10%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKC------LDKKRIKMKQGETLALNERIMLSLVSTGD 250 +G G FG V+ C + TG+++ K LDK +K NE +S+++ Sbjct: 59 LGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVK---------NE---ISIMNQLH 106 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEHMH 309 P ++ + AF ++ IL+ ++GG+L ++ SEA++ Y + GL+HMH Sbjct: 107 HPKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMH 166 Query: 310 NRFVVYRDLKPANILLD--EHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQK-G 365 +V+ D+KP NI+ + + V+I D GLA + + + T + APE++ + Sbjct: 167 EHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVDREP 226 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFR-QHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 424 V + D +++G + + LL G SPF + + + R + S SPE + Sbjct: 227 VGF--YTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDF 284 Query: 425 LEGLLQRDVNRRL 437 ++ LLQ++ +RL Sbjct: 285 IKNLLQKEPRKRL 297 >3IS5-A nrPDB Length = 285 Score = 83.6 bits (205), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 73/262 (27%), Positives = 126/262 (48%), Gaps = 22/262 (8%) Query: 187 TMND-FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKR--IKMKQGETLALNERIML 243 T++D F R +G G FG+V+ + +G +K ++K R + M+Q E + Sbjct: 19 TIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEA-------EI 71 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 ++ + D P I+ + F + +++ GG+L + +A Y AE++ Sbjct: 72 EVLKSLDHPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMK 131 Query: 304 ----GLEHMHNRFVVYRDLKPANILLDE---HGHVRISDLGLACDF-SKKKPHASVGTHG 355 L + H++ VV++DLKP NIL + H ++I D GLA F S + + GT Sbjct: 132 QMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTAL 191 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-KHEIDRMTLTMAVELP 414 YMAPEV ++ V + D +S G +++ LL G PF ++ + + AVE Sbjct: 192 YMAPEVFKRDVTF--KCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAVEC- 248 Query: 415 DSFSPELRSLLEGLLQRDVNRR 436 +P+ LL+ +L +D RR Sbjct: 249 RPLTPQAVDLLKQMLTKDPERR 270 >4AN9-A nrPDB Length = 301 Score = 82.8 bits (203), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 105/205 (51%), Gaps = 11/205 (5%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +DF +G G G V+ +G + A K + +++K A+ +I+ L Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI---HLEIKP----AIRNQIIRELQVL 61 Query: 249 GDC--PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 +C P+IV AF++ ++S ++ M+GG L L + G E + + +I GL Sbjct: 62 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 121 Query: 307 HMHNRF-VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKG 365 ++ + +++RD+KP+NIL++ G +++ D G++ + + VGT YM+PE LQ G Sbjct: 122 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQ-G 180 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSP 390 Y +D +S+G L ++ G P Sbjct: 181 THYSVQSDIWSMGLSLVEMAVGRYP 205 >1S9I-A nrPDB Length = 354 Score = 82.4 bits (202), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 59/217 (27%), Positives = 107/217 (49%), Gaps = 11/217 (5%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +DF +G G G V + +G + A K + +++K A+ +I+ L Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLI---HLEIKP----AIRNQIIRELQVL 68 Query: 249 GDC--PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 +C P+IV AF++ ++S ++ M+GG L L + E + + ++ GL Sbjct: 69 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLA 128 Query: 307 HMHNRF-VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKG 365 ++ + +++RD+KP+NIL++ G +++ D G++ ++ VGT YMAPE LQ G Sbjct: 129 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ-G 187 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI 402 Y +D +S+G L +L G P K+ I Sbjct: 188 THYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAI 224 >4UYA-A nrPDB Length = 340 Score = 82.0 bits (201), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 63/251 (25%), Positives = 119/251 (47%), Gaps = 24/251 (9%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL--DKKRIKMKQGETLALNERI 241 +H+ + +IG GGFG+VY R G+ A+K D ++ E++ R+ Sbjct: 21 VHVAFERLELKELIGAGGFGQVY--RATWQGQEVAVKAARQDPEQDAAAAAESVRREARL 78 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 L P I+ + L +L+ GG L+ L+ + + +A +I Sbjct: 79 FAMLRH----PNIIELRGVCLQQPHLCLVLEFARGGALNRALAGRRIPPHVLVN-WAVQI 133 Query: 302 ILGLEHMHNRF---VVYRDLKPANILLDE--------HGHVRISDLGLACDFSKKKPHAS 350 G+ ++H +++RDLK +NILL E + ++I+D GLA ++ + A+ Sbjct: 134 ARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMAT 193 Query: 351 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR---QHKTKDKHEIDRMTL 407 G + +MAPEV++ + + +D +S G +L++LL G P+R ++++TL Sbjct: 194 AGAYAWMAPEVIKSSL-FSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTL 252 Query: 408 TMAVELPDSFS 418 + P+ F+ Sbjct: 253 PIPSTCPEPFA 263 >3GUB-A nrPDB Length = 295 Score = 81.6 bits (200), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 72/284 (25%), Positives = 131/284 (46%), Gaps = 22/284 (7%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKM-KQGETLALNERIMLSLVSTGDCPFIV 255 +G G F V CR+ TG YA K + K+R K ++G + ER +S++ P ++ Sbjct: 19 LGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIER-EVSILKEIQHPNVI 77 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 + + + I +L+ GG+L L++ +E + + +I+ G+ ++H+ + + Sbjct: 78 TLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAH 137 Query: 316 RDLKPANILLDEHG----HVRISDLGLA--CDFSKKKPHASVGTHGYMAPEVLQKGVAYD 369 DLKP NI+L + ++I D GLA DF + + GT ++APE+ V Y+ Sbjct: 138 FDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNI-FGTPEFVAPEI----VNYE 192 Query: 370 S---SADWFSLGCMLFKLLRGHSPF-RQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 AD +S+G + + LL G SPF K + + + E + S + + Sbjct: 193 PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFI 252 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPP 469 LL +D +R+ Q+ + P+ + D Q + P Sbjct: 253 RRLLVKDPKKRMTI-----QDSLQHPWIKPKDTQQALSSAWSHP 291 >2HW6-A nrPDB Length = 307 Score = 81.6 bits (200), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 71/292 (24%), Positives = 123/292 (42%), Gaps = 42/292 (14%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 ++G G + +V G GK YA+K ++K+ G + + R + +L I+ Sbjct: 20 LLGEGAYAKVQGAVSLQNGKEYAVKIIEKQ-----AGHSRSRVFREVETLYQCQGNKNIL 74 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 + F + + + + GG + H+ + F+E + ++ L+ +H + + + Sbjct: 75 ELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAH 134 Query: 316 RDLKPANILLDEH---GHVRISDLGLACDFSKKKPHASV---------GTHGYMAPEVLQ 363 RDLKP NIL + V+I D L + G+ YMAPEV++ Sbjct: 135 RDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVE 194 Query: 364 ----KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK----DKHEIDRMTLTM------ 409 + YD D +SLG +L+ +L G+ PF H D+ E+ R+ Sbjct: 195 VFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQ 254 Query: 410 --AVELPDS----FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 E PD S E + L+ LL RD +RL A +V + P+ + Sbjct: 255 EGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRL-----SAAQVLQHPWVQG 301 >3F3Z-A nrPDB Length = 277 Score = 80.9 bits (198), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 70/255 (27%), Positives = 114/255 (44%), Gaps = 13/255 (5%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 +++ IGRG +GEV + T A K + K ++ + IM SL D Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVE--DVDRFKQEIEIMKSL----D 64 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P I+ + F + +++L GG+L + VF E+D +++ + + H Sbjct: 65 HPNIIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHK 124 Query: 311 RFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGV 366 V +RDLKP N L +++ D GLA F K VGT Y++P+VL+ Sbjct: 125 LNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEG-- 182 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFSPELRSLL 425 Y D +S G M++ LL G+ PF + +I T T + + SP+ SL+ Sbjct: 183 LYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLI 242 Query: 426 EGLLQRDVNRRLGCL 440 LL + +R+ L Sbjct: 243 RRLLTKSPKQRITSL 257 >6AO5-A nrPDB Length = 362 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 58/237 (24%), Positives = 114/237 (48%), Gaps = 19/237 (8%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F V +G G +G V+ ++G++ A+K ++ ++ + E +S++ D Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIK-----QVPVESDLQEIIKE---ISIMQQCD 63 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADMRFYAAEIILGLEHMH 309 P++V ++ L +++ G + + ++ E ++ + GLE++H Sbjct: 64 SPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLH 123 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVA 367 ++R++K NILL+ GH +++D G+A + K + +GT +MAPEV+Q+ + Sbjct: 124 FMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-IG 182 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSF-SPELRS 423 Y+ AD +SLG ++ G P+ D H + R + P +F PEL S Sbjct: 183 YNCVADIWSLGITSIEMAEGKPPY-----ADIHPM-RAIFMIPTNPPPTFRKPELWS 233 >3NIZ-A nrPDB Length = 311 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 73/298 (24%), Positives = 133/298 (44%), Gaps = 49/298 (16%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKM-KQGETLALNERIMLSLVSTGDCPFIV 255 +G G +G VY + + G++ A+K RI++ + E + +SL+ P IV Sbjct: 29 VGEGTYGVVYKAKDSQ-GRIVALK-----RIRLDAEDEGIPSTAIREISLLKELHHPNIV 82 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEHMHNRFVV 314 + H+ L+ + + M DL L ++ ++ ++ Y +++ G+ H H ++ Sbjct: 83 SLIDVIHSERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCHQHRIL 141 Query: 315 YRDLKPANILLDEHGHVRISDLGLACDFS---KKKPHASVGTHGYMAPEVLQKGVAYDSS 371 +RDLKP N+L++ G ++++D GLA F + H V T Y AP+VL Y +S Sbjct: 142 HRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVV-TLWYRAPDVLMGSKKYSTS 200 Query: 372 ADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV----------ELP------- 414 D +S+GC+ +++ G F D ++ ++ + ELP Sbjct: 201 VDIWSIGCIFAEMITGKPLFP--GVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQRTF 258 Query: 415 ------------DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQM 460 F E LL +L D N+R+ A++ P+F+ LD Q+ Sbjct: 259 QVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRI-----SARDAMNHPYFKDLDPQI 311 >2BPM-A nrPDB Length = 309 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 135/300 (45%), Gaps = 42/300 (14%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 M +F IG G +G VY R TG++ A+K + + + + + A+ E +SL+ Sbjct: 6 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIRE---ISLLK 61 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEIILGL 305 + P IV + HT +KL + + ++ DL + + ++ Y +++ GL Sbjct: 62 ELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGL 120 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS---KKKPHASVGTHGYMAPEVL 362 H+ V++RDLKP N+L++ G ++++D GLA F + H V T Y APE+L Sbjct: 121 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEIL 179 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK--------HEIDRMTLTMAVELP 414 Y ++ D +SLGC+ +++ + F D+ D + +P Sbjct: 180 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 239 Query: 415 D-----------SFS---PEL----RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 D FS P L RSLL +L D N+R+ A+ PFF+ + Sbjct: 240 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDV 294 >1G3N-A nrPDB Length = 326 Score = 79.7 bits (195), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 66/218 (30%), Positives = 109/218 (50%), Gaps = 24/218 (11%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE----TLALNERIMLSLVSTGDCP 252 IG G +G+V+ R G + KR++++ GE + E +L + T + P Sbjct: 19 IGEGAYGKVFKARDLKNGGRFVAL----KRVRVQTGEEGMPLSTIREVAVLRHLETFEHP 74 Query: 253 -----FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS---QHGVFSEA--DMRFYAAEII 302 F VC KL+ + + ++ DL +L + GV +E DM F +++ Sbjct: 75 NVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMF---QLL 130 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHGYMAPEV 361 GL+ +H+ VV+RDLKP NIL+ G ++++D GLA +S + S V T Y APEV Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 399 L + +Y + D +S+GC+ ++ R FR D+ Sbjct: 191 LLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQ 227 >3TAC-A nrPDB Length = 361 Score = 79.7 bits (195), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 101/211 (47%), Gaps = 11/211 (5%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 +IG+G F V C +TG+ +A+K +D + G + +R S+ P IV Sbjct: 33 VIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKR-EASICHMLKHPHIV 91 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG----VFSEADMRFYAAEIILGLEHMHNR 311 + + + L + + M+G DL + + + V+SEA Y +I+ L + H+ Sbjct: 92 ELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDN 151 Query: 312 FVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKKPHAS--VGTHGYMAPEVLQKGV 366 +++RD+KP +LL + V++ G+A + A VGT +MAPEV+++ Sbjct: 152 NIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKRE- 210 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTK 397 Y D + G +LF LL G PF K + Sbjct: 211 PYGKPVDVWGCGVILFILLSGCLPFYGTKER 241 >3UIM-A nrPDB Length = 326 Score = 79.7 bits (195), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 73/239 (30%), Positives = 112/239 (46%), Gaps = 24/239 (10%) Query: 167 ESDKFTRFCQWKNVEL-NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK 225 E D Q K L + + ++FS I+GRGGFG+VY R AD G + A+K L ++ Sbjct: 7 EEDPEVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGRLAD-GTLVAVKRLKEE 65 Query: 226 RIKMKQGETLALNERIMLSLVSTGDCPFI--VCMSYAFHTPDKLSFILDLMNGGDLHYHL 283 R + GE E M+S+ + + CM TP + + M G + L Sbjct: 66 RTQ--GGELQFQTEVEMISMAVHRNLLRLRGFCM-----TPTERLLVYPYMANGSVASCL 118 Query: 284 SQHGVFSEADMRFYAAEIIL-----GLEHMHNRF---VVYRDLKPANILLDEHGHVRISD 335 + S+ + + + I GL ++H+ +++RD+K ANILLDE + D Sbjct: 119 RERPE-SQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGD 177 Query: 336 LGLACDFSKKKPHASV---GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 GLA K H + GT G++APE L G + + + D F G ML +L+ G F Sbjct: 178 FGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKT-DVFGYGVMLLELITGQRAF 235 >6GU6-A nrPDB Length = 302 Score = 79.0 bits (193), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 107/208 (51%), Gaps = 20/208 (9%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE----TLALNERIM 242 +M D++ IG G +G VY R TG++ AMK +I+++ E + A+ E Sbjct: 5 SMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK-----KIRLESEEEGVPSTAIRE--- 56 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADM-RFYAA 299 +SL+ P IV + +L I + ++ DL +L G + ++ + + Y Sbjct: 57 ISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLY 115 Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS---KKKPHASVGTHGY 356 +I+ G+ H+R V++RDLKP N+L+D+ G ++++D GLA F + H V T Y Sbjct: 116 QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWY 174 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKL 384 +PEVL Y + D +S+G + +L Sbjct: 175 RSPEVLLGSARYSTPVDIWSIGTIFAEL 202 >4LG4-A nrPDB Length = 299 Score = 79.0 bits (193), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 58/237 (24%), Positives = 114/237 (48%), Gaps = 19/237 (8%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F V +G G +G V+ ++G++ A+K ++ ++ + E +S++ D Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIK-----QVPVESDLQEIIKE---ISIMQQCD 64 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADMRFYAAEIILGLEHMH 309 P++V ++ L +++ G + + ++ E ++ + GLE++H Sbjct: 65 SPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLH 124 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVA 367 ++R++K NILL+ GH +++D G+A + K + +GT +MAPEV+Q+ + Sbjct: 125 FMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-IG 183 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSF-SPELRS 423 Y+ AD +SLG ++ G P+ D H + R + P +F PEL S Sbjct: 184 YNCVADIWSLGITSIEMAEGKPPY-----ADIHPM-RAIFMIPTNPPPTFRKPELWS 234 >5O2C-A nrPDB Length = 380 Score = 78.6 bits (192), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 61/249 (24%), Positives = 115/249 (46%), Gaps = 13/249 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +GRG F VY +T A L +++ + + ++ L F Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 92 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF--VV 314 + + +LM G L +L + V +R + +I+ GL+ +H R ++ Sbjct: 93 WESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPII 152 Query: 315 YRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSAD 373 +RDLK NI + G V+I DLGLA + +GT +MAPE+ ++ YD S D Sbjct: 153 HRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE--HYDESVD 210 Query: 374 WFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS----PELRSLLEGLL 429 ++ G + ++ P+ + ++ +I R +T ++ P SF+ PE++ ++EG + Sbjct: 211 VYAFGMCMLEMATSEYPYSE--CQNAAQIYR-KVTSGIK-PASFNKVTDPEVKEIIEGCI 266 Query: 430 QRDVNRRLG 438 +++ + RL Sbjct: 267 RQNKSERLS 275 >4X7Q-B nrPDB Length = 312 Score = 78.6 bits (192), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 58/253 (22%), Positives = 113/253 (44%), Gaps = 15/253 (5%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI----KMKQGETLALNERIMLSL 245 ++ + ++G+GGFG V+ + A+K + + R+ + T L ++ + Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILD-LMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 + G P ++ + F T + +L+ + DL ++++ G E R + +++ Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 151 Query: 305 LEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 363 ++H H+R VV+RD+K NIL+D G ++ D G + GT Y PE + Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWIS 211 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 + + A +SLG +L+ ++ G PF E D+ L + P SP+ + Sbjct: 212 RHQYHALPATVWSLGILLYDMVCGDIPF---------ERDQEILEAELHFPAHVSPDCCA 262 Query: 424 LLEGLLQRDVNRR 436 L+ L + R Sbjct: 263 LIRRCLAPKPSSR 275 >3VN9-A nrPDB Length = 340 Score = 78.6 bits (192), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 74/284 (26%), Positives = 130/284 (45%), Gaps = 27/284 (9%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 N + +D +GRG +G V R +G++ A+K + + + ++ + L ++ I Sbjct: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDIS 103 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGG-DLHYH--LSQHGVFSEADMRFYAA 299 + V DCPF V A + ++LM+ D Y + + E + A Sbjct: 104 MRTV---DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 Query: 300 EIILGLEHMHNRF-VVYRDLKPANILLDEHGHVRISDLGLA---CDFSKKKPHASVGTHG 355 I+ LEH+H++ V++RD+KP+N+L++ G V++ D G++ D K A G Sbjct: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA--GCKP 218 Query: 356 YMAPEVL-----QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA 410 YMAPE + QKG Y +D +SLG + +L P+ T ++ ++ + Sbjct: 219 YMAPERINPELNQKG--YSVKSDIWSLGITMIELAILRFPYDSWGTP-FQQLKQVVEEPS 275 Query: 411 VELP-DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 +LP D FS E L+++ R E+ + PFF Sbjct: 276 PQLPADKFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 314 >3ALO-A nrPDB Length = 327 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 62/256 (24%), Positives = 117/256 (45%), Gaps = 24/256 (9%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IGRG +G V +G++ A+K + + + K+ + L ++ +++ + DCP+IV Sbjct: 30 IGRGAYGSVNKMVHKPSGQIMAVKRI-RSTVDEKEQKQLLMDLDVVMR---SSDCPYIVQ 85 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG----LEHM-HNR 311 A ++LM+ ++ + V + +I L L H+ N Sbjct: 86 FYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENL 145 Query: 312 FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA-SVGTHGYMAPEVLQKGVA--- 367 +++RD+KP+NILLD G++++ D G++ G YMAPE + + Sbjct: 146 KIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQG 205 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPD-------SFSPE 420 YD +D +SLG L++L G P+ + + D++T + + P FSP Sbjct: 206 YDVRSDVWSLGITLYELATGRFPYPKWNSV----FDQLTQVVKGDPPQLSNSEEREFSPS 261 Query: 421 LRSLLEGLLQRDVNRR 436 + + L +D ++R Sbjct: 262 FINFVNLCLTKDESKR 277 >4UY9-A nrPDB Length = 323 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 61/220 (27%), Positives = 111/220 (50%), Gaps = 17/220 (7%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + + + ++ IIG GGFG+VY R G A+K + +T+ N R Sbjct: 4 LEIDFAELTLEEIIGIGGFGKVY--RAFWIGDEVAVKAA-RHDPDEDISQTIE-NVRQEA 59 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 L + P I+ + L +++ GG L+ LS + + + +A +I Sbjct: 60 KLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVN-WAVQIAR 118 Query: 304 GLEHMHNRFVV---YRDLKPANILL---DEHGHV-----RISDLGLACDFSKKKPHASVG 352 G+ ++H+ +V +RDLK +NIL+ E+G + +I+D GLA ++ + ++ G Sbjct: 119 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAG 178 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR 392 T+ +MAPEV++ + + +D +S G +L++LL G PFR Sbjct: 179 TYAWMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFR 217 >5AIR-A nrPDB Length = 430 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 109/217 (50%), Gaps = 31/217 (14%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMK-CLDKKRIKMKQGETLALNERIMLSLVSTG 249 ++ ++IG G FG VY + D+G++ A+K L KR K ++ L ++ Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRE-----------LQIMRKL 114 Query: 250 DCPFIVCMSYAFHTPDK------LSFILDLMNGGDLHYHLSQHGVFSEAD-------MRF 296 D IV + Y F++ + L+ +LD + + Y +++H +S A ++ Sbjct: 115 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYV--PETVYRVARH--YSRAKQTLPVIYVKL 170 Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHV-RISDLGLACDFSKKKPHAS-VGTH 354 Y ++ L ++H+ + +RD+KP N+LLD V ++ D G A + +P+ S + + Sbjct: 171 YMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 230 Query: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 Y APE++ Y SS D +S GC+L +LL G F Sbjct: 231 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIF 267 >4MVF-A nrPDB Length = 506 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 56/199 (28%), Positives = 101/199 (50%), Gaps = 12/199 (6%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G+G +G VY T ++YA+K ++K+ ++K IM L D P IV Sbjct: 65 LGQGTYGCVYKGIDKVTNQLYAIK--EEKKDRLKNINRFFQEIEIMKKL----DHPNIVK 118 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + + + + I++L +G +L + ++G F+E + +I + ++H+ +V+R Sbjct: 119 LYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVHR 178 Query: 317 DLKPANILL---DEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGVAYDSSA 372 DLKP N L ++ ++I D GL+ + + GT Y+AP+VL YD Sbjct: 179 DLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG--KYDKKC 236 Query: 373 DWFSLGCMLFKLLRGHSPF 391 D +S G +++ LL G+ PF Sbjct: 237 DIWSSGVIMYTLLCGYPPF 255 >4O2Z-A nrPDB Length = 377 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 55/219 (25%), Positives = 107/219 (48%), Gaps = 16/219 (7%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTG-KMYAMKCLD-------KKRIKMKQGETLALNERIM 242 +++ +I+G G +G C DTG K+ KC D KR+ + + + Sbjct: 47 YTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENL 106 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 L++V+ + + +H+ + + + LM+ D++ L V E+ M+++ +I+ Sbjct: 107 LNVVN-----ILPPLKREYHSFEDVYVVTPLMDV-DMNVVLRSRQVLEESHMQYFVYQIL 160 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGL--ACDFSKKKPHASVGTHGYMAPE 360 GL+++H+ V +RDLKPAN++ + ++I D GL + D + V T Y PE Sbjct: 161 RGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPE 220 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 399 +L + Y ++ D +S+GC+ ++ F T D+ Sbjct: 221 LLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQ 259 >5O2B-A nrPDB Length = 285 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 61/248 (24%), Positives = 115/248 (46%), Gaps = 13/248 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +GRG F VY +T A L +++ + + ++ L F Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 83 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF--VV 314 + + +LM G L +L + V +R + +I+ GL+ +H R ++ Sbjct: 84 WESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPII 143 Query: 315 YRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSAD 373 +RDLK NI + G V+I DLGLA + +GT +MAPE+ ++ YD S D Sbjct: 144 HRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE--HYDESVD 201 Query: 374 WFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS----PELRSLLEGLL 429 ++ G + ++ P+ + ++ +I R +T ++ P SF+ PE++ ++EG + Sbjct: 202 VYAFGMCMLEMATSEYPYSE--CQNAAQIYR-KVTSGIK-PASFNKVTDPEVKEIIEGCI 257 Query: 430 QRDVNRRL 437 +++ + RL Sbjct: 258 RQNKSERL 265 >3GC9-A nrPDB Length = 370 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 49/198 (24%), Positives = 100/198 (50%), Gaps = 3/198 (1%) Query: 195 RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 254 R +G G +G V A + A+K L + + R++ L + Sbjct: 34 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLL 93 Query: 255 VCMSYAFHTPD-KLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFV 313 + A D +++ + G DL+ ++ + S+ ++F +++ GL+++H+ + Sbjct: 94 DVFTPATSIEDFSEVYLVTTLMGADLN-NIVKSQALSDEHVQFLVYQLLRGLKYIHSAGI 152 Query: 314 VYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSAD 373 ++RDLKP+N+ ++E +RI D GLA + ++ V T Y APE++ + Y+ + D Sbjct: 153 IHRDLKPSNVAVNEDSELRILDFGLARQ-ADEEMTGYVATRWYRAPEIMLNWMHYNQTVD 211 Query: 374 WFSLGCMLFKLLRGHSPF 391 +S+GC++ +LL+G + F Sbjct: 212 IWSVGCIMAELLQGKALF 229 >5D7A-A nrPDB Length = 308 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 66/285 (23%), Positives = 125/285 (43%), Gaps = 40/285 (14%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD---------KKRIKMKQGETLALNERI 241 F + ++G G +G+VY R TG++ A+K +D K+ I M + + N Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 78 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL--SQHGVFSEADMRFYAA 299 + P + D+L +++ G + + ++ E + + Sbjct: 79 YYGAFIKKNPPGM---------DDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 129 Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC--DFSKKKPHASVGTHGYM 357 EI+ GL H+H V++RD+K N+LL E+ V++ D G++ D + + + +GT +M Sbjct: 130 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 189 Query: 358 APEVL----QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVEL 413 APEV+ YD +D +SLG ++ G P D H + + L Sbjct: 190 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPL-----CDMHPMRALFLIPRNPA 244 Query: 414 P----DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 P +S + +S +E L ++ ++R +++ + PF R Sbjct: 245 PRLKSKKWSKKFQSFIESCLVKNHSQR-----PATEQLMKHPFIR 284 >4BGQ-A nrPDB Length = 304 Score = 77.8 bits (190), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 58/212 (27%), Positives = 95/212 (44%), Gaps = 8/212 (3%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 NI MN F + ++G G +G V CR +T ++ A+K + ET L E M Sbjct: 6 NIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKET-TLRELKM 64 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 L + + IV + AF KL + + + L ++ Y ++I Sbjct: 65 LRTLKQEN---IVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI 121 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP---HASVGTHGYMAP 359 + H +V+RD+KP N+L+ + +++ D G A + S+ V T Y +P Sbjct: 122 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSP 181 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 E+L G Y S D +S+GC+L +L G F Sbjct: 182 ELLL-GAPYGKSVDMWSVGCILGELSDGQPLF 212 >4G3E-A nrPDB Length = 352 Score = 77.8 bits (190), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 60/206 (29%), Positives = 97/206 (47%), Gaps = 20/206 (9%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +GRG FGEV+ + TG A+K K R+ E + E + + +S+ P IV Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVK---KVRL-----EVFRVEELVACAGLSS---PRIVP 130 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + A ++ ++L+ GG L + Q G E +Y + + GLE++H R +++ Sbjct: 131 LYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHG 190 Query: 317 DLKPANILLDEHG-HVRISDLGLACDFSKKKPHASV-------GTHGYMAPEVLQKGVAY 368 D+K N+LL G + D G A S+ GT +MAPEV+ G Sbjct: 191 DVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVM-GKPC 249 Query: 369 DSSADWFSLGCMLFKLLRGHSPFRQH 394 D+ D +S CM+ +L G P+ Q+ Sbjct: 250 DAKVDIWSSCCMMLHMLNGCHPWTQY 275 >6O6Q-A nrPDB Length = 335 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 62/228 (27%), Positives = 110/228 (48%), Gaps = 22/228 (9%) Query: 177 WKNVELNIHLT-MNDFSVHRIIGRGGFGEVY---GCRKADTGKMYAMKCLDKKRIKMKQG 232 W +LNI ++ + R +GRG + EV+ K + + +K + +K+IK + Sbjct: 28 WDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIKREIS 87 Query: 233 ETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLS--FILDLMNGGDLHYHLSQHGVFS 290 I+ +LV D P I+ M P + I + +N D S + F+ Sbjct: 88 --------ILKNLV---DGPNIIAMLDVVREPQSKTPGLIFEHINNIDFR---SLYPTFT 133 Query: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPH- 348 + D+RFY E++ L++ H+ +++RD+KP N+++D + +R+ D GLA + + Sbjct: 134 DYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYN 193 Query: 349 ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKT 396 V + + PE+L YD S D +S GCML ++ PF K+ Sbjct: 194 VRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKS 241 >3PPZ-A nrPDB Length = 309 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 71/263 (26%), Positives = 122/263 (46%), Gaps = 33/263 (12%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 D ++ IG G FG V+ R G A+K L ++ ++ IM L Sbjct: 38 DLNIKEKIGAGSFGTVH--RAEWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRH-- 93 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMR---FYAAEIILGLE 306 P IV A P LS + + ++ G L+ L + G + D R A ++ G+ Sbjct: 94 --PNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMN 151 Query: 307 HMHNRF--VVYRDLKPANILLDEHGHVRISDLGL----ACDFSKKKPHASVGTHGYMAPE 360 ++HNR +V+RDLK N+L+D+ V++ D GL A F K ++ GT +MAPE Sbjct: 152 YLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSK--SAAGTPEWMAPE 209 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV-------EL 413 VL+ + + S D +S G +L++L P+ ++ + AV E+ Sbjct: 210 VLRDEPSNEKS-DVYSFGVILWELATLQQPW--------GNLNPAQVVAAVGFKCKRLEI 260 Query: 414 PDSFSPELRSLLEGLLQRDVNRR 436 P + +P++ +++EG + +R Sbjct: 261 PRNLNPQVAAIIEGCWTNEPWKR 283 >4KIK-B nrPDB Length = 677 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 73/266 (27%), Positives = 121/266 (45%), Gaps = 40/266 (15%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMK-CLDKKRIKMKQGETLALNERIMLSL-----VSTGD 250 +G GGFG V +TG+ A+K C ++ + + E L +IM L V+ D Sbjct: 27 LGTGGFGNVIRWHNQETGEQIAIKQC--RQELSPRNRERWCLEIQIMRRLTHPNVVAARD 84 Query: 251 CPFIVCMSYAFHTPDKLSFI-LDLMNGGDLHYHLSQHGV---FSEADMRFYAAEIILGLE 306 P P+ L + ++ GGDL +L+Q E + ++I L Sbjct: 85 VP----EGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 140 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVR----ISDLGLACDFSKKKPHAS-VGTHGYMAPEV 361 ++H +++RDLKP NI+L + G R I DLG A + + S VGT Y+APE+ Sbjct: 141 YLHENRIIHRDLKPENIVL-QQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 199 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQH--------KTKDKHEID---------R 404 L++ Y + D++S G + F+ + G PF + K + K E+D Sbjct: 200 LEQQ-KYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGT 258 Query: 405 MTLTMAVELPDSFSPELRSLLEGLLQ 430 + + ++ P++ + L LE LQ Sbjct: 259 VKFSSSLPYPNNLNSVLAERLEKWLQ 284 >4EQM-A nrPDB Length = 294 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 44/142 (30%), Positives = 75/142 (52%), Gaps = 4/142 (2%) Query: 254 IVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFV 313 IV M D +++ + G L ++ HG S + +I+ G++H H+ + Sbjct: 73 IVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHDMRI 132 Query: 314 VYRDLKPANILLDEHGHVRISDLGLA---CDFSKKKPHASVGTHGYMAPEVLQKGVAYDS 370 V+RD+KP NIL+D + ++I D G+A + S + + +GT Y +PE KG A D Sbjct: 133 VHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPE-QAKGEATDE 191 Query: 371 SADWFSLGCMLFKLLRGHSPFR 392 D +S+G +L+++L G PF Sbjct: 192 CTDIYSIGIVLYEMLVGEPPFN 213 >4YFF-A nrPDB Length = 311 Score = 77.0 bits (188), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 63/224 (28%), Positives = 103/224 (45%), Gaps = 20/224 (8%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 + HL +++ H IIG G FG+VY R + K+ A+K K + E Sbjct: 36 HFHLQLSEIEFHEIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSDVDMFCRE--- 90 Query: 243 LSLVSTGDCPFIV-CMSYAFHTPDKLSFILDLMNGGDLHYHL-SQHGVFSEADMRFYAAE 300 +S++ + P ++ + + P + + + ++GG L L Q + A + Sbjct: 91 VSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVD 150 Query: 301 IILGLEHMHN--RFVVYRDLKPANILLDEHGHVRISDLG-------LACDFSKKKPHASV 351 + G+E++HN + +++RDL NILL E GH ++D G L D K+P Sbjct: 151 VAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQP---- 206 Query: 352 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHK 395 G +MAPEV + Y AD FS L+++L G PF K Sbjct: 207 GNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLK 250 >4IDT-A nrPDB Length = 356 Score = 77.0 bits (188), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 71/263 (26%), Positives = 121/263 (46%), Gaps = 38/263 (14%) Query: 191 FSVHRI-IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 ++ H++ +GRG FGEV+ TG A+K K R+++ + E L L S Sbjct: 75 WATHQLRLGRGSFGEVHRMEDKQTGFQCAVK---KVRLEVFRAEELM----ACAGLTS-- 125 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 P IV + A ++ ++L+ GG L + + G E +Y + + GLE++H Sbjct: 126 --PRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLH 183 Query: 310 NRFVVYRDLKPANILLDEHG-HVRISDLGLACDFSKKKPHASV-------GTHGYMAPEV 361 +R +++ D+K N+LL G H + D G A + GT +MAPEV Sbjct: 184 SRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEV 243 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV--------EL 413 + G + D+ D +S CM+ +L G P+ Q R L + + E+ Sbjct: 244 VL-GRSCDAKVDVWSSCCMMLHMLNGCHPWTQ--------FFRGPLCLKIASEPPPVREI 294 Query: 414 PDSFSP-ELRSLLEGLLQRDVNR 435 P S +P +++ EGL + ++R Sbjct: 295 PPSCAPLTAQAIQEGLRKEPIHR 317 >5VD3-A nrPDB Length = 311 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 76/257 (29%), Positives = 115/257 (44%), Gaps = 28/257 (10%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMK-CLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 +G G +GEV+ R + G++YA+K + R + LA + S G P V Sbjct: 65 LGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLA----EVGSHEKVGQHPCCV 120 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEHMHNRFVV 314 + A+ L +L G L H G EA + Y + +L L H+H++ +V Sbjct: 121 RLEQAWEEGGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLV 179 Query: 315 YRDLKPANILLDEHGHVRISDLGLACDF-SKKKPHASVGTHGYMAPEVLQKGVAYDSSAD 373 + D+KPANI L G ++ D GL + + G YMAPE+LQ +Y ++AD Sbjct: 180 HLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQG--SYGTAAD 237 Query: 374 WFSLGCMLF------KLLRGHSPFRQHK--------TKDKHEIDRMTLTMAVELPDSFSP 419 FSLG + +L G ++Q + T R L M +E PD P Sbjct: 238 VFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLE-PD---P 293 Query: 420 ELRSLLEGLLQRDVNRR 436 +LR+ E LL V R+ Sbjct: 294 KLRATAEALLALPVLRQ 310 >3FME-A nrPDB Length = 290 Score = 76.6 bits (187), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 71/271 (26%), Positives = 126/271 (46%), Gaps = 29/271 (10%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +GRG +G V R +G++ A+K + + + ++ + L ++ I + V DCPF V Sbjct: 15 LGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTV---DCPFTVT 70 Query: 257 MSYAFHTPDKLSFILDLMNGG-DLHYH--LSQHGVFSEADMRFYAAEIILGLEHMHNRF- 312 A + ++LM+ D Y + + E + A I+ LEH+H++ Sbjct: 71 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 130 Query: 313 VVYRDLKPANILLDEHGHVRISDLGLAC----DFSKKKPHASVGTHGYMAPEVL-----Q 363 V++RD+KP+N+L++ G V++ D G++ D +K G YMAPE + Q Sbjct: 131 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAK---DIDAGCKPYMAPERINPELNQ 187 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP-DSFSPELR 422 KG Y +D +SLG + +L P+ T ++ ++ + +LP D FS E Sbjct: 188 KG--YSVKSDIWSLGITMIELAILRFPYDSWGTP-FQQLKQVVEEPSPQLPADKFSAEFV 244 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 L+++ R E+ + PFF Sbjct: 245 DFTSQCLKKNSKER-----PTYPELMQHPFF 270 >3QA8-A nrPDB Length = 676 Score = 76.3 bits (186), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 103/222 (46%), Gaps = 27/222 (12%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMK-CLDKKRIKMKQGETLALNERIMLSL 245 T + + +G GGFG V DTG+ A+K C ++ + K E L +IM L Sbjct: 12 TCGPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQC--RQELSPKNRERWCLEIQIMKKL 69 Query: 246 VSTGDCPFIVCMSYAFHTPDKLS---------FILDLMNGGDLHYHLSQHGV---FSEAD 293 + P +V A PD L ++ GGDL +L+Q E Sbjct: 70 ----NHPNVVS---AREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGP 122 Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHV---RISDLGLACDFSKKKPHAS 350 +R ++I L ++H +++RDLKP NI+L +I DLG A + + + Sbjct: 123 IRTLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTE 182 Query: 351 -VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 VGT Y+APE+L++ Y + D++S G + F+ + G PF Sbjct: 183 FVGTLQYLAPELLEQK-KYTVTVDYWSFGTLAFECITGFRPF 223 >4MYG-A nrPDB Length = 372 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 62/229 (27%), Positives = 102/229 (44%), Gaps = 58/229 (25%) Query: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH 348 FSE +++ +++ GL+++H+ VV+RDLKP N+ ++E ++I D GLA + + Sbjct: 142 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLA-RHADAEMT 200 Query: 349 ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT 408 V T Y APEV+ + Y+ + D +S+GC++ ++L G + F K K +D++T Sbjct: 201 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLF-----KGKDYLDQLTQI 255 Query: 409 MAV----------------------ELPDS-----------FSPELRSLLEGLLQRDVNR 435 + V LP + SP+ LLE +L+ DV++ Sbjct: 256 LKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDK 315 Query: 436 RLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFD 484 RL A + PFF P P E A FD Sbjct: 316 RL-----TAAQALTHPFFE--------------PFRDPEEETEAQQPFD 345 >4RC3-A nrPDB Length = 289 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 99/209 (47%), Gaps = 8/209 (3%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI----KMKQGETLALNERIMLS 244 + + V ++G GGFG VY + A+K ++K RI ++ G + + E ++L Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM-EVVLLK 70 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNG-GDLHYHLSQHGVFSEADMRFYAAEIIL 303 VS+G I + + F PD IL+ DL +++ G E R + +++ Sbjct: 71 KVSSGFSGVIRLLDW-FERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 129 Query: 304 GLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL 362 + H HN V++RD+K NIL+D G +++ D G GT Y PE + Sbjct: 130 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI 189 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 + + SA +SLG +L+ ++ G PF Sbjct: 190 RYHRYHGRSAAVWSLGILLYDMVCGDIPF 218 >5TUR-A nrPDB Length = 404 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 99/209 (47%), Gaps = 8/209 (3%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI----KMKQGETLALNERIMLS 244 + + V ++G GGFG VY + A+K ++K RI ++ G + + E ++L Sbjct: 127 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM-EVVLLK 185 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNG-GDLHYHLSQHGVFSEADMRFYAAEIIL 303 VS+G I + + F PD IL+ DL +++ G E R + +++ Sbjct: 186 KVSSGFSGVIRLLDW-FERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 244 Query: 304 GLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL 362 + H HN V++RD+K NIL+D G +++ D G GT Y PE + Sbjct: 245 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI 304 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 + + SA +SLG +L+ ++ G PF Sbjct: 305 RYHRYHGRSAAVWSLGILLYDMVCGDIPF 333 >4F0G-A nrPDB Length = 287 Score = 75.9 bits (185), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 72/269 (26%), Positives = 131/269 (48%), Gaps = 28/269 (10%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE----RI 241 L N+ + IG+GGFG V+ R + A+K L + +GET + + + Sbjct: 16 LADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSL---ILGDSEGETEMIEKFQEFQR 72 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL--SQHGVFSEADMRFYAA 299 + ++S + P IV + H P ++ +++ + GDL++ L H + +R Sbjct: 73 EVFIMSNLNHPNIVKLYGLMHNPPRM--VMEFVPCGDLYHRLLDKAHPIKWSVKLRL-ML 129 Query: 300 EIILGLEHMHNRF--VVYRDLKPANIL---LDEHGHV--RISDLGLACDFSKKKPHASVG 352 +I LG+E+M N+ +V+RDL+ NI LDE+ V +++D GL S++ H+ G Sbjct: 130 DIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGL----SQQSVHSVSG 185 Query: 353 THG---YMAPEVL-QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRM-TL 407 G +MAPE + + +Y AD +S +L+ +L G PF ++ I+ + Sbjct: 186 LLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREE 245 Query: 408 TMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + +P+ P LR+++E D +R Sbjct: 246 GLRPTIPEDCPPRLRNVIELCWSGDPKKR 274 >4AU8-A nrPDB Length = 296 Score = 75.9 bits (185), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 54/201 (26%), Positives = 99/201 (49%), Gaps = 14/201 (6%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE----TLALNERIMLSLVSTGDCP 252 IG G +G V+ + +T ++ A+K R+++ + + AL E +L + + Sbjct: 14 IGEGTYGTVFKAKNRETHEIVALK-----RVRLDDDDEGVPSSALREICLLKELKHKN-- 66 Query: 253 FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF 312 IV + H+ KL+ + + + Y S +G ++ + +++ GL H+R Sbjct: 67 -IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRN 125 Query: 313 VVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVGTHGYMAPEVLQKGVAYDS 370 V++RDLKP N+L++ +G ++++D GLA F + A V T Y P+VL Y + Sbjct: 126 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 185 Query: 371 SADWFSLGCMLFKLLRGHSPF 391 S D +S GC+ +L P Sbjct: 186 SIDMWSAGCIFAELANAGRPL 206 >4KRC-A nrPDB Length = 317 Score = 75.5 bits (184), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 95/203 (46%), Gaps = 14/203 (6%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G + VY TG A+K +K+ E +SL+ IV Sbjct: 13 LGNGTYATVYKGLNKTTGVYVALK-----EVKLDSEEGTPSTAIREISLMKELKHENIVR 67 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEAD------MRFYAAEIILGLEHMHN 310 + HT +KL+ + + M+ DL ++ V + ++++ +++ GL H Sbjct: 68 LYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVGTHGYMAPEVLQKGVAY 368 +++RDLKP N+L+++ G +++ D GLA F + V T Y AP+VL Y Sbjct: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 Query: 369 DSSADWFSLGCMLFKLLRGHSPF 391 +S D +S GC+L +++ G F Sbjct: 187 STSIDIWSCGCILAEMITGKPLF 209 >6CQF-A nrPDB Length = 297 Score = 75.5 bits (184), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 98/199 (49%), Gaps = 10/199 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G +GEV+ R +G + A+K +KM+ + ++ ++ +L ++ T IV Sbjct: 24 LGGGTYGEVFKARDKVSGDLVALKM-----VKMEPDDDVSTLQKEIL-ILKTCRHANIVA 77 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 ++ KL ++ G L G SE + + E++ GL ++H++ ++R Sbjct: 78 YHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHR 137 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGV--AYDSSA 372 D+K ANIL+++ G VR++D G++ + A +GT +MAPEV + Y+ Sbjct: 138 DIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGGYNELC 197 Query: 373 DWFSLGCMLFKLLRGHSPF 391 D +SLG +L P Sbjct: 198 DIWSLGITAIELAELQPPL 216 >2XNP-A nrPDB Length = 279 Score = 75.1 bits (183), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 62/222 (27%), Positives = 100/222 (45%), Gaps = 18/222 (8%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 D+ V IG G +G R+ GK+ K LD + + + L ++ L Sbjct: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH-- 64 Query: 250 DCPFIVCMSYAF--HTPDKLSFILDLMNGGDLHYHLS----QHGVFSEADMRFYAAEIIL 303 P IV T L +++ GGDL ++ + E + ++ L Sbjct: 65 --PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTL 122 Query: 304 GLEHMHNR-----FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS--VGTHGY 356 L+ H R V++RDLKPAN+ LD +V++ D GLA + A VGT Y Sbjct: 123 ALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYY 182 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 M+PE + + ++Y+ +D +SLGC+L++L PF K+ Sbjct: 183 MSPEQMNR-MSYNEKSDIWSLGCLLYELCALMPPFTAFSQKE 223 >4QNY-A nrPDB Length = 354 Score = 75.1 bits (183), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 59/217 (27%), Positives = 110/217 (50%), Gaps = 17/217 (7%) Query: 191 FSVHRIIGRGGFGEVYGCRKADT-GKMYAMKCLDKKRIKMKQGETLALNERIM--LSLVS 247 + + RIIG G +G V R + ++ AMK R+ + E + L +RI+ + L++ Sbjct: 22 YLLERIIGAGSYGVVIRARDTKSDNRLVAMK-----RVNKEIFEEVILAKRILREIKLLA 76 Query: 248 TGDCPFIVCMSYAFHTPDKLSF-----ILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 + I+ + D +F ++D+M DL L +EA ++F+ + + Sbjct: 77 HFNDDNIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVLRSGQELTEAHIQFFIYQAL 135 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS--VGTHGYMAPE 360 L +H+ V++RD+ PANIL++ + ++I D GLA + + + + + V Y APE Sbjct: 136 RALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPE 195 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK 397 ++ + Y + D + +GC+L +LL G P Q K + Sbjct: 196 LVMEDKDYSAQIDVWGIGCILGELL-GSRPLFQGKDR 231 >3BGP-A nrPDB Length = 333 Score = 75.1 bits (183), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 99/209 (47%), Gaps = 8/209 (3%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI----KMKQGETLALNERIMLS 244 + + V ++G GGFG VY + A+K ++K RI ++ G + + E ++L Sbjct: 56 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM-EVVLLK 114 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNG-GDLHYHLSQHGVFSEADMRFYAAEIIL 303 VS+G I + + F PD IL+ DL +++ G E R + +++ Sbjct: 115 KVSSGFSGVIRLLDW-FERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 173 Query: 304 GLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL 362 + H HN V++RD+K NIL+D G +++ D G GT Y PE + Sbjct: 174 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI 233 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 + + SA +SLG +L+ ++ G PF Sbjct: 234 RYHRYHGRSAAVWSLGILLYDMVCGDIPF 262 >1V0B-A nrPDB Length = 288 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 57/199 (28%), Positives = 102/199 (51%), Gaps = 11/199 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G +G VY + + G+ +A+K K R++ K+ E + +S++ IV Sbjct: 10 IGEGTYGVVYKAQN-NYGETFALK---KIRLE-KEDEGIPSTTIREISILKELKHSNIVK 64 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQ-HGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 + HT +L + + ++ DL L G + + +++ G+ + H+R V++ Sbjct: 65 LYDVIHTKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLH 123 Query: 316 RDLKPANILLDEHGHVRISDLGLACDFS---KKKPHASVGTHGYMAPEVLQKGVAYDSSA 372 RDLKP N+L++ G ++I+D GLA F +K H V T Y AP+VL Y ++ Sbjct: 124 RDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVV-TLWYRAPDVLMGSKKYSTTI 182 Query: 373 DWFSLGCMLFKLLRGHSPF 391 D +S+GC+ +++ G F Sbjct: 183 DIWSVGCIFAEMVNGAPLF 201 >4PWN-A nrPDB Length = 274 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/249 (25%), Positives = 115/249 (46%), Gaps = 16/249 (6%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IGRG F VY +T A L +++ + + ++ L F Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDS 77 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF--VV 314 + + +LM G L +L + V +R + +I+ GL+ +H R ++ Sbjct: 78 WESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPII 137 Query: 315 YRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHAS--VGTHGYMAPEVLQKGVAYDSS 371 +RDLK NI + G V+I DLGLA K+ A +GT +MAPE+ ++ YD S Sbjct: 138 HRDLKCDNIFITGPTGSVKIGDLGLA-TLEKRASFAKSVIGTPEFMAPEMYEE--KYDES 194 Query: 372 ADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS----PELRSLLEG 427 D ++ G + ++ P+ + ++ +I R +T V+ P SF PE++ ++EG Sbjct: 195 VDVYAFGMCMLEMATSEYPYSE--CQNAAQIYR-RVTSGVK-PASFDKVAIPEVKEIIEG 250 Query: 428 LLQRDVNRR 436 ++++ + R Sbjct: 251 CIRQNKDER 259 >4NST-A nrPDB Length = 351 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 62/233 (26%), Positives = 112/233 (48%), Gaps = 43/233 (18%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQG-------ETLALNE 239 ++ F + IIG G +G+VY + DTG++ A+K K R+ K+G E L + Sbjct: 12 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALK---KVRLDNEKEGFPITAIREIKILRQ 68 Query: 240 RIMLSLVSTGDC---------------PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS 284 I S+V+ + F + Y H ++ L+ G +H Sbjct: 69 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHD------LMGLLESGLVH---- 118 Query: 285 QHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS- 343 FSE ++ + +++ GLE+ H + ++RD+K +NILL+ G ++++D GLA ++ Sbjct: 119 ----FSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS 174 Query: 344 -KKKPHAS-VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQH 394 + +P+ + V T Y PE+L Y + D +S GC+L +L F+ + Sbjct: 175 EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 227 >4IC8-A nrPDB Length = 442 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 58/235 (24%), Positives = 114/235 (48%), Gaps = 22/235 (9%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML----- 243 +++ + IG G +G V R+ TG+ A+K + + L E +L Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNA-FDVVTNAKRTLRELKILKHFKH 113 Query: 244 -SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 ++++ D I+ + + + +LDLM DLH + + +R++ +++ Sbjct: 114 DNIIAIKD---ILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLL 169 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA---CDFSKKKPH---ASVGTHGY 356 GL++MH+ V++RDLKP+N+L++E+ ++I D G+A C + + V T Y Sbjct: 170 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 229 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV 411 APE++ Y + D +S+GC+ ++L R+ K+ + ++ L M V Sbjct: 230 RAPELMLSLHEYTQAIDLWSVGCIFGEMLA-----RRQLFPGKNYVHQLQLIMMV 279 >3DTC-A nrPDB Length = 271 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 110/220 (50%), Gaps = 17/220 (7%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + + + ++ IIG GGFG+VY R G A+K + +T+ N R Sbjct: 2 LEIDFAELTLEEIIGIGGFGKVY--RAFWIGDEVAVKA-ARHDPDEDISQTIE-NVRQEA 57 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 L + P I+ + L +++ GG L+ LS + + + +A +I Sbjct: 58 KLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVN-WAVQIAR 116 Query: 304 GLEHMHNRFVV---YRDLKPANILL---DEHGHV-----RISDLGLACDFSKKKPHASVG 352 G+ ++H+ +V +RDLK +NIL+ E+G + +I+D GLA ++ + ++ G Sbjct: 117 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAG 176 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR 392 + +MAPEV++ + + +D +S G +L++LL G PFR Sbjct: 177 AYAWMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFR 215 >4U41-A nrPDB Length = 332 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 102/213 (47%), Gaps = 16/213 (7%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F + ++G G +G+VY R TG++ A+K +D + + E + L E ML S Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD---VTEDEEEEIKL-EINMLKKYSHHR 81 Query: 251 CPFIVCMSYAFHTP----DKLSFILDLMNGGDLHYHL--SQHGVFSEADMRFYAAEIILG 304 ++ +P D+L +++ G + + ++ E + + + EI+ G Sbjct: 82 NIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRG 141 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC--DFSKKKPHASVGTHGYMAPEVL 362 L H+H V++RD+K N+LL E+ V++ D G++ D + + + +GT +MAPEV+ Sbjct: 142 LAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 201 Query: 363 ----QKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 YD +D +S G ++ G P Sbjct: 202 ACDENPDATYDYRSDLWSCGITAIEMAEGAPPL 234 >3ZDU-A nrPDB Length = 325 Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 98/198 (49%), Gaps = 15/198 (7%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G +G V C+ +TG++ A+K ++ + +A+ E L + +V Sbjct: 11 VGEGSYGTVMKCKHKNTGQIVAIKIFYER--PEQSVNKIAMREIKFLKQFHHEN---LVN 65 Query: 257 MSYAFHTPDKLSFILDLMNGGDL----HYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF 312 + F K+ + + ++ L HY HG+ S+ +R Y +I+ ++++H+ Sbjct: 66 LIEVFRQKKKIHLVFEFIDHTVLDELQHY---CHGLESKR-LRKYLFQILRAIDYLHSNN 121 Query: 313 VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLQKGVAYDS 370 +++RD+KP NIL+ + G ++ D G A + V T Y APE++ K +Y Sbjct: 122 IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYGK 181 Query: 371 SADWFSLGCMLFKLLRGH 388 D ++LGCM+ ++ G+ Sbjct: 182 PVDIWALGCMIIEMATGN 199 >4ZSG-A nrPDB Length = 347 Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/235 (24%), Positives = 114/235 (48%), Gaps = 22/235 (9%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML----- 243 +++ + IG G +G V R+ TG+ A+K + + L E +L Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNA-FDVVTNAKRTLRELKILKHFKH 65 Query: 244 -SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 ++++ D I+ + + + +LDLM DLH + + +R++ +++ Sbjct: 66 DNIIAIKD---ILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLL 121 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA---CDFSKKKPH---ASVGTHGY 356 GL++MH+ V++RDLKP+N+L++E+ ++I D G+A C + + V T Y Sbjct: 122 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 181 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV 411 APE++ Y + D +S+GC+ ++L R+ K+ + ++ L M V Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEMLA-----RRQLFPGKNYVHQLQLIMMV 231 >6CKI-A nrPDB Length = 316 Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 75/293 (25%), Positives = 120/293 (40%), Gaps = 44/293 (15%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 ++G G V C T + YA+K ++K+ G + R + L ++ Sbjct: 20 VLGEGAHARVQTCINLITSQEYAVKIIEKQ-----PGHIRSRVFREVEMLYQCQGHRNVL 74 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 + F D+ + + M GG + H+ + F+E + ++ L+ +HN+ + + Sbjct: 75 ELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAH 134 Query: 316 RDLKPANILLDEHGH---VRISDLGLA--------CD-FSKKKPHASVGTHGYMAPEVL- 362 RDLKP NIL + V+I D GL C S + G+ YMAPEV+ Sbjct: 135 RDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVE 194 Query: 363 ---QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV-------- 411 ++ YD D +SLG +L+ LL G+ PF D DR A Sbjct: 195 AFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDC-GWDRGEACPACQNMLFESI 253 Query: 412 -----ELPDS----FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 E PD S + L+ LL RD +RL A +V + P+ + Sbjct: 254 QEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRL-----SAAQVLQHPWVQG 301 >5G6V-A nrPDB Length = 324 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 49/198 (24%), Positives = 95/198 (47%), Gaps = 9/198 (4%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G + VY + T + A+K I+++ E +SL+ IV Sbjct: 10 LGEGTYATVYKGKSKLTDNLVALK-----EIRLEHEEGAPCTAIREVSLLKDLKHANIVT 64 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIILGLEHMHNRFVVY 315 + HT L+ + + ++ DL +L G + + +++ + +++ GL + H + V++ Sbjct: 65 LHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLH 123 Query: 316 RDLKPANILLDEHGHVRISDLGL--ACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSAD 373 RDLKP N+L++E G ++++D GL A K V T Y P++L Y + D Sbjct: 124 RDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDYSTQID 183 Query: 374 WFSLGCMLFKLLRGHSPF 391 + +GC+ +++ G F Sbjct: 184 MWGVGCIFYEMATGRPLF 201 >5EFQ-A nrPDB Length = 347 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/234 (26%), Positives = 112/234 (47%), Gaps = 43/234 (18%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-KMKQG-------ETLALNE 239 ++ F + IIG G +G+VY R DTG+M A+K K R+ K+G E L + Sbjct: 10 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALK---KVRLDNEKEGFPITAIREIKILRQ 66 Query: 240 RIMLSLVSTGDC---------------PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS 284 S+++ + F + Y H ++ L+ G +H Sbjct: 67 LTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD------LMGLLESGLVH---- 116 Query: 285 QHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS- 343 F+E ++ + +++ GL++ H + ++RD+K +NILL+ G ++++D GLA +S Sbjct: 117 ----FNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSS 172 Query: 344 -KKKPHAS-VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHK 395 + +P+ + V T Y PE+L Y + D +S GC+L +L F+ ++ Sbjct: 173 EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQ 226 >5WNL-A nrPDB Length = 342 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 71/260 (27%), Positives = 117/260 (45%), Gaps = 32/260 (12%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL------DKKRIKMKQGETLALNERIM 242 +F+ +G GGFG+VY R A+KC D++R+++ + + Sbjct: 20 GEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFR 79 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRF-YAAEI 301 L G C + + +++ M G L L+ + D+RF E Sbjct: 80 YILPVYGICQ------------EPVGLVMEYMETGSLEKLLASEPL--PWDLRFRIVHET 125 Query: 302 ILGLEHMH--NRFVVYRDLKPANILLDEHGHVRISDLGLA-CDFSKKKPHASV----GTH 354 +G+ +H + +++ +LKPANILLD H HV+ISD GLA C+ S+ GT Sbjct: 126 AVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTI 185 Query: 355 GYMAPE-VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVEL 413 Y+ PE + +K +D+ D +S +++ +L PF K H + ++ EL Sbjct: 186 AYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNI-LHIMMKVVKGHRPEL 244 Query: 414 PDSFSPELRSL--LEGLLQR 431 P P R+ L GL+QR Sbjct: 245 PPICRPRPRACASLIGLMQR 264 >4AGU-A nrPDB Length = 311 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 73/295 (24%), Positives = 121/295 (41%), Gaps = 49/295 (16%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCL----DKKRIKMKQGETLALNERIMLSLVSTGDCP 252 IG G +G V+ CR DTG++ A+K D IK +AL E ML + P Sbjct: 11 IGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIK-----KIALREIRMLKQLKH---P 62 Query: 253 FIVCMSYAFHTPDKLSFILDLMNGGDLH-YHLSQHGVFSEADMRFYAAEIILGLEHMHNR 311 +V + F +L + + + LH Q GV E ++ + + + H Sbjct: 63 NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGV-PEHLVKSITWQTLQAVNFCHKH 121 Query: 312 FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS--VGTHGYMAPEVLQKGVAYD 369 ++RD+KP NIL+ +H +++ D G A + + V T Y +PE+L Y Sbjct: 122 NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQYG 181 Query: 370 SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT----------------MAVEL 413 D +++GC+ +LL G + D+ + R TL V++ Sbjct: 182 PPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKI 241 Query: 414 PD------------SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 PD + S LL+G L D RL C +++ P+F ++ Sbjct: 242 PDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTC-----EQLLHHPYFENI 291 >2BRG-A nrPDB Length = 297 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 56/226 (24%), Positives = 102/226 (45%), Gaps = 41/226 (18%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + D+ + + +G G +GEV T + A+K +D KR Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR--------------------- 44 Query: 248 TGDCPFIV----CMSYAFHTPDKLSF------------ILDLMNGGDLHYHLSQHGVFSE 291 DCP + C++ + + + F L+ +GG+L + E Sbjct: 45 AVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPE 104 Query: 292 ADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF----SKKKP 347 D + + +++ G+ ++H + +RD+KP N+LLDE +++ISD GLA F ++ Sbjct: 105 PDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLL 164 Query: 348 HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQ 393 + GT Y+APE+L++ + D +S G +L +L G P+ Q Sbjct: 165 NKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQ 210 >6DTL-A nrPDB Length = 364 Score = 72.8 bits (177), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 57/199 (28%), Positives = 99/199 (49%), Gaps = 19/199 (9%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG+G +G V ++T + A+K + K L E + L+ D IV Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKI-ANAFDNKIDAKRTLRE---IKLLRHMDHENIVA 93 Query: 257 MSYAFHTPDKLSF-----ILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNR 311 + P + +F +LM+ DLH + + SE +++ +I+ GL+++H+ Sbjct: 94 IRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 152 Query: 312 FVVYRDLKPANILLDEHGHVRISDLGLA-----CDFSKKKPHASVGTHGYMAPEVLQKGV 366 V++RDLKP+N+LL+ + ++I D GLA DF + V T Y APE+L Sbjct: 153 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTE----YVVTRWYRAPELLLNSS 208 Query: 367 AYDSSADWFSLGCMLFKLL 385 Y ++ D +S+GC+ +L+ Sbjct: 209 DYTAAIDVWSVGCIFMELM 227 >5TOS-A nrPDB Length = 395 Score = 72.8 bits (177), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 65/224 (29%), Positives = 103/224 (45%), Gaps = 28/224 (12%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGC---------RKADTGKMYAMKCLDKKRIKMKQGET 234 + L +F +IG GGFG V+ K TG + A+K L+++ QG Sbjct: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF---QGHR 116 Query: 235 LALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADM 294 L E L +S + + + Y +L + + M G L HL + G + + Sbjct: 117 EWLTEINYLGQLSHPN--LVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 Query: 295 RFYAAEIIL----GLEHMHNR--FVVYRDLKPANILLDEHGHVRISDLGLA-----CDFS 343 F + L GL +H+ V+YRD+K +NILLD + ++SD GLA D S Sbjct: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 Query: 344 KKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRG 387 +GT+GY APE + G ++ +D +S G +L ++L G Sbjct: 234 YVSTRV-MGTYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSG 275 >1CM8-A nrPDB Length = 367 Score = 72.8 bits (177), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 65/241 (26%), Positives = 113/241 (46%), Gaps = 17/241 (7%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G +G V TG A+K K + Q E A L L+ ++ Sbjct: 33 VGSGAYGAVCSAVDGRTGAKVAIK----KLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88 Query: 257 MSYAFHTPDK-------LSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 + F TPD+ ++ M G DL L +H E ++F +++ GL ++H Sbjct: 89 LLDVF-TPDETLDDFTDFYLVMPFM-GTDLG-KLMKHEKLGEDRIQFLVYQMLKGLRYIH 145 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYD 369 +++RDLKP N+ ++E ++I D GLA + + V T Y APEV+ + Y Sbjct: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVTRWYRAPEVILNWMRYT 204 Query: 370 SSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSF-SPELRSLLEG 427 + D +S+GC++ +++ G + F+ D+ EI ++T T E S E ++ ++G Sbjct: 205 QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKG 264 Query: 428 L 428 L Sbjct: 265 L 265 >2PMN-X nrPDB Length = 348 Score = 72.4 bits (176), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 54/225 (24%), Positives = 103/225 (45%), Gaps = 23/225 (10%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM----- 242 +ND+ + R + +G F ++ C K + K YA+K +K ++ K+ T + N++I Sbjct: 30 INDYRIIRTLNQGKFNKIILCEKDN--KFYALKKYEKSLLEKKRDFTKSNNDKISIKSKY 87 Query: 243 ------LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRF 296 L +++ + + D++ I + M + V + F Sbjct: 88 DDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCF 147 Query: 297 YAAEIIL--------GLEHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 347 ++I ++HN + + +RD+KP+NIL+D++G V++SD G + KK Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKI 207 Query: 348 HASVGTHGYMAPEVLQKGVAYDSS-ADWFSLGCMLFKLLRGHSPF 391 S GT+ +M PE +Y+ + D +SLG L+ + PF Sbjct: 208 KGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF 252 >4BBM-A nrPDB Length = 331 Score = 72.0 bits (175), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 62/221 (28%), Positives = 104/221 (47%), Gaps = 34/221 (15%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-----DK--KRIKMKQGETLA-LN 238 +M + ++G G +G V CR DTG++ A+K DK K+I M++ + L L Sbjct: 23 SMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR 82 Query: 239 ERIMLSL--VSTGDCPFIVCMSYAFHTPDKLSFILDLM----NGGDLHYHLSQHGVFSEA 292 +++L V + + + HT ILD + NG L Y + Q +F Sbjct: 83 HENLVNLLEVCKKKKRWYLVFEFVDHT------ILDDLELFPNG--LDYQVVQKYLF--- 131 Query: 293 DMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HAS 350 +II G+ H+ +++RD+KP NIL+ + G V++ D G A + Sbjct: 132 -------QIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDE 184 Query: 351 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 V T Y APE+L V Y + D +++GC++ ++ G F Sbjct: 185 VATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLF 225 >3ORP-A nrPDB Length = 311 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 103/223 (46%), Gaps = 28/223 (12%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK---------RIKMKQGETL 235 HL+ + + + I+G GG EV+ R + A+K L R + + Sbjct: 9 HLS-DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAA 67 Query: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHTP-DKLSFI-LDLMNGGDLHYHLSQHGVFSEAD 293 ALN ++++ TG+ TP L +I ++ ++G L + G + Sbjct: 68 ALNHPAIVAVYDTGEA----------ETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKR 117 Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA-----CDFSKKKPH 348 A+ L H +++RD+KPANI++ V++ D G+A S + Sbjct: 118 AIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTA 177 Query: 349 ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 A +GT Y++PE +G + D+ +D +SLGC+L+++L G PF Sbjct: 178 AVIGTAQYLSPE-QARGDSVDARSDVYSLGCVLYEVLTGEPPF 219 >4EWQ-A nrPDB Length = 383 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 59/238 (24%), Positives = 115/238 (48%), Gaps = 7/238 (2%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G +G V TG A+K L + + + R++ + + Sbjct: 53 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 112 Query: 257 MSYA--FHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVV 314 + A + + + LM G DL+ ++ + ++ ++F +I+ GL+++H+ ++ Sbjct: 113 FTPARSLEEFNDVYLVTHLM-GADLN-NIVKCQKLTDDHVQFLIYQILRGLKYIHSADII 170 Query: 315 YRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADW 374 +RDLKP+N+ ++E ++I D GLA + + V T Y APE++ + Y+ + D Sbjct: 171 HRDLKPSNLAVNEDCELKILDFGLA-RHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDI 229 Query: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSFSPE-LRSLLEGLLQ 430 +S+GC++ +LL G + F D+ + I R+ T EL S E R+ ++ L Q Sbjct: 230 WSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQ 287 >5HI2-A nrPDB Length = 283 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 104/219 (47%), Gaps = 26/219 (11%) Query: 191 FSVHRIIGRGGFGEVY-GCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 +V + IG G FG VY G D A+K L ++++ + E L + T Sbjct: 22 ITVGQRIGSGSFGTVYKGKWHGDV----AVKMLTPQQLQAFKNEVGVLRK--------TR 69 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRF---YAAEIILGLE 306 ++ M Y+ T +L+ + G L++HL H ++ +M+ A + G++ Sbjct: 70 HVNILLFMGYS--TKPQLAIVTQWCEGSSLYHHL--HASETKFEMKKLIDIARQTARGMD 125 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV----GTHGYMAPEV- 361 ++H + +++RDLK NI L E V+I D GLA S+ G+ +MAPEV Sbjct: 126 YLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 185 Query: 362 -LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 399 +Q Y +D ++ G +L++L+ G P+ +D+ Sbjct: 186 RMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ 224 >5LPZ-A nrPDB Length = 332 Score = 70.5 bits (171), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 71/246 (28%), Positives = 105/246 (42%), Gaps = 23/246 (9%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-----DKKRIKMKQGETLA-LNERIM 242 N F +IG GGFG+VY D G A+K L R M + ET+ + R + Sbjct: 17 NGFHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNL 75 Query: 243 LSLVS---TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAA 299 + L+ GD +V Y F L +L + + S + R A Sbjct: 76 VPLLGYCKVGDERLLV---YEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAF 132 Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV----GTHG 355 L H + +++RD+K +N+LLDE+ R+SD G+A S H SV GT G Sbjct: 133 -----LHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPG 187 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPD 415 Y+ PE Q + D +S G +L +LL G P D + + + + + D Sbjct: 188 YVPPEYYQS-FRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISD 246 Query: 416 SFSPEL 421 F PEL Sbjct: 247 VFDPEL 252 >6EII-A nrPDB Length = 352 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 46/155 (29%), Positives = 80/155 (51%), Gaps = 7/155 (4%) Query: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKK 346 ++ D+RFY EI+ L++ H+ +++RD+KP N+++D EH +R+ D GLA + + Sbjct: 150 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 209 Query: 347 PH-ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRM 405 + V + + PE+L YD S D +SLGCML ++ PF H + ++ R+ Sbjct: 210 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF-HGHDNYDQLVRI 268 Query: 406 TLTMAVE----LPDSFSPELRSLLEGLLQRDVNRR 436 + E D ++ EL +L R +R Sbjct: 269 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 303 >5LPV-A nrPDB Length = 296 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 71/246 (28%), Positives = 105/246 (42%), Gaps = 23/246 (9%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-----DKKRIKMKQGETLA-LNERIM 242 N F +IG GGFG+VY D G A+K L R M + ET+ + R + Sbjct: 17 NGFHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNL 75 Query: 243 LSLVS---TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAA 299 + L+ GD +V Y F L +L + + S + R A Sbjct: 76 VPLLGYCKVGDERLLV---YEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAF 132 Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV----GTHG 355 L H + +++RD+K +N+LLDE+ R+SD G+A S H SV GT G Sbjct: 133 -----LHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPG 187 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPD 415 Y+ PE Q + D +S G +L +LL G P D + + + + + D Sbjct: 188 YVPPEYYQS-FRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISD 246 Query: 416 SFSPEL 421 F PEL Sbjct: 247 VFDPEL 252 >3N9X-A nrPDB Length = 432 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 61/235 (25%), Positives = 106/235 (45%), Gaps = 39/235 (16%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 N+H+ N + + +IGRG +G VY +T K A+K +++ E L +RI+ Sbjct: 21 NVHVPDN-YIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNR------MFEDLIDCKRIL 73 Query: 243 --LSLVSTGDCPFIVCMSYAFHTPDKLS-----FILDLMNGGDLHYHLSQHGVFSEADMR 295 +++++ +I+ + Y PD L +I+ + DL +E ++ Sbjct: 74 REITILNRLKSDYIIRL-YDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIFLTEEHIK 132 Query: 296 FYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK--------- 346 ++LG +H +++RDLKPAN LL++ V++ D GLA + +K Sbjct: 133 TILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLE 192 Query: 347 ------PH---------ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR 386 PH + V T Y APE++ Y S D +S GC+ +LL Sbjct: 193 ENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLN 247 >3FXW-A nrPDB Length = 336 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 100/207 (48%), Gaps = 22/207 (10%) Query: 195 RIIGRGGFGEVYGCRKADTGKMYAMKCL-DKKRIKMKQGETLALNERIMLSLVSTGDCPF 253 +++G G G+V C TG+ A+K L D + + + + ++G P Sbjct: 35 QVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKAR----------QEVDHHWQASGG-PH 83 Query: 254 IVCMSYAF----HTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAEIILGLEH 307 IVC+ + H L I++ M GG+L + + G F+E + +I ++ Sbjct: 84 IVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQF 143 Query: 308 MHNRFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 364 +H+ + +RD+KP N+L ++ ++++D G A + ++ T Y+APEVL Sbjct: 144 LHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGP 203 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPF 391 YD S D +SLG +++ LL G PF Sbjct: 204 E-KYDKSCDMWSLGVIMYILLCGFPPF 229 >2F9G-A nrPDB Length = 353 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 102/212 (48%), Gaps = 20/212 (9%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL---DKKRIKMKQGETLALNERIMLSL 245 +DF + ++G G +G V TG++ A+K + DK ++ + + + Sbjct: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 + T F + +F +++ I +LM DLH +S + S+ ++++ + + + Sbjct: 71 IITI---FNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQ-MLSDDHIQYFIYQTLRAV 125 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGL-------ACDFSKKKPHAS-----VGT 353 + +H V++RDLKP+N+L++ + +++ D GL A D S+ S V T Sbjct: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 Query: 354 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL 385 Y APEV+ Y + D +S GC+L +L Sbjct: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 >3OMV-A nrPDB Length = 307 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 95/210 (45%), Gaps = 15/210 (7%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G FG VY + + +K +D + + A + + L T ++ Sbjct: 44 IGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQ-----AFRNEVAV-LRKTRHVNILLF 97 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 M Y T D L+ + G L+ HL Q F + A + G++++H + +++ Sbjct: 98 MGYM--TKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIH 155 Query: 316 RDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV----GTHGYMAPEV--LQKGVAYD 369 RD+K NI L E V+I D GLA S+ V G+ +MAPEV +Q + Sbjct: 156 RDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFS 215 Query: 370 SSADWFSLGCMLFKLLRGHSPFRQHKTKDK 399 +D +S G +L++L+ G P+ +D+ Sbjct: 216 FQSDVYSYGIVLYELMTGELPYSHINNRDQ 245 >4MD7-E nrPDB Length = 391 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 68/275 (24%), Positives = 124/275 (45%), Gaps = 26/275 (9%) Query: 169 DKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIK 228 D + +W N +D+ + R +GRG + EV+ + +K L + K Sbjct: 25 DYESHVVEWGN--------QDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK 76 Query: 229 MKQGETLAL-NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG 287 + E L N R ++++ D + TP + + + +N D + Sbjct: 77 KIKREIKILENLRGGPNIITLAD----IVKDPVSRTP---ALVFEHVNNTDFK---QLYQ 126 Query: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKK 346 ++ D+RFY EI+ L++ H+ +++RD+KP N+++D EH +R+ D GLA + + Sbjct: 127 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 186 Query: 347 PH-ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRM 405 + V + + PE+L YD S D +SLGCML ++ PF H + ++ R+ Sbjct: 187 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFF-HGHDNYDQLVRI 245 Query: 406 TLTMAVE----LPDSFSPELRSLLEGLLQRDVNRR 436 + E D ++ EL +L R +R Sbjct: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 280 >4GS6-A nrPDB Length = 315 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 102/213 (47%), Gaps = 29/213 (13%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL--VS 247 + V ++GRG FG V C+ K + +KQ E+ + + ++ L +S Sbjct: 10 EIEVEEVVGRGAFGVV--CKAK----------WRAKDVAIKQIESESERKAFIVELRQLS 57 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-----FSEADMRFYAAEII 302 + P IV + A P + +++ GG L+ L HG ++ A + + Sbjct: 58 RVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVL--HGAEPLPYYTAAHAMSWCLQCS 113 Query: 303 LGLEHMHN---RFVVYRDLKPANILLDEHGHV-RISDLGLACDFSKKKPHASVGTHGYMA 358 G+ ++H+ + +++RDLKP N+LL G V +I D G ACD + + G+ +MA Sbjct: 114 QGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTN-NKGSAAWMA 172 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 PEV + G Y D FS G +L++++ PF Sbjct: 173 PEVFE-GSNYSEKCDVFSWGIILWEVITRRKPF 204 >5Z33-A nrPDB Length = 425 Score = 68.9 bits (167), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 103/220 (46%), Gaps = 16/220 (7%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDK---KRIKMKQGETLALNERIMLSLVS 247 ++V + +G+G +G V T + A+K + K+I K+ AL E +L Sbjct: 33 YTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKR----ALREIKLLQHFR 88 Query: 248 TGDCPFIVCMSYAFHTPDKL--SFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 G PD +++ + + DL + ++A + + +I+ GL Sbjct: 89 -GHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGL 147 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS------VGTHGYMAP 359 +++H+ V++RDLKP N+L++ ++I D GLA FS + V T Y AP Sbjct: 148 KYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAP 207 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 399 E++ +Y + D +S+GC+L +LL G F+ D+ Sbjct: 208 EIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQ 247 >5XVU-A nrPDB Length = 332 Score = 68.9 bits (167), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 107/222 (48%), Gaps = 16/222 (7%) Query: 174 FCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE 233 + + N+EL + N + + + IGRG + EV+ Y +C IK+ + Sbjct: 17 YYDYDNLELQWN-KPNRYEIMKKIGRGKYSEVFNG--------YDTECNRPCAIKVLKPV 67 Query: 234 TLALNERIMLSLVSTGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHLSQHGVFSE 291 +R + L + P I+ + P S I + +N D + + F++ Sbjct: 68 KKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFK---TLYPKFTD 124 Query: 292 ADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPH-A 349 D+R+Y +I+ L++ H++ +++RD+KP NI++D E+ +R+ GLA + + + Sbjct: 125 KDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNV 184 Query: 350 SVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 V + Y PE+L YD S D +SLGCML ++ PF Sbjct: 185 RVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPF 226 >5VDK-A nrPDB Length = 297 Score = 68.6 bits (166), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 71/267 (26%), Positives = 114/267 (42%), Gaps = 37/267 (13%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G FG VY C K G +YA+K K ++ E AL+E +++ G P +V Sbjct: 23 IGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSN-ENSALHEVYAHAVL--GHHPHVVR 79 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQH----GVFSEADMRFYAAEIILGLEHMHNRF 312 ++ D + + NGG L +S++ F E ++ +I LGL ++HN Sbjct: 80 YYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSS 139 Query: 313 VVYRDLKPANI-----------------------LLDEHGHVRISDLGLACDFSKKKPHA 349 +V+ D+KP+NI L + +I DLG A S KP Sbjct: 140 MVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHAT--SINKPKV 197 Query: 350 SVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTM 409 G ++A E+LQ+ + AD F+LG + + G + H I + Sbjct: 198 EEGDSRFLANEILQEDYRHLPKADIFALG-LTIAVAAGAESLPTNGAA-WHHIRKGNFP- 254 Query: 410 AVELPDSFSPELRSLLEGLLQRDVNRR 436 ++P S SLL+ ++Q D +R Sbjct: 255 --DVPQELSESFSSLLKNMIQPDAEQR 279 >6GVJ-A nrPDB Length = 429 Score = 68.6 bits (166), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 63/269 (23%), Positives = 122/269 (45%), Gaps = 33/269 (12%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-----DKKRIKMKQGETLALNERIMLSL 245 +S+ + IG GG +V+ + ++YA+K + D + + + E LN+ L Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNK-----L 199 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 D + Y + D+ +++ DL+ L + + + Y ++ + Sbjct: 200 QQHSD---KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 256 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC----DFSKKKPHASVGTHGYMAPEV 361 +H +V+ DLKPAN L+ + G +++ D G+A D + + VGT YM PE Sbjct: 257 HTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 315 Query: 362 LQKGVAYDSSA----------DWFSLGCMLFKLLRGHSPFRQ--HKTKDKHEIDRMTLTM 409 ++ + + D +SLGC+L+ + G +PF+Q ++ H I + Sbjct: 316 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAI--IDPNH 373 Query: 410 AVELPDSFSPELRSLLEGLLQRDVNRRLG 438 +E PD +L+ +L+ L+RD +R+ Sbjct: 374 EIEFPDIPEKDLQDVLKCCLKRDPKQRIS 402 >3OHT-A nrPDB Length = 389 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 35/123 (28%), Positives = 75/123 (60%), Gaps = 2/123 (1%) Query: 269 FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEH 328 +++ + G DL+ ++ + ++ ++F +I+ GL+++H+ +++RDLKP+N+ ++E Sbjct: 132 YLVTHLMGADLN-NIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED 190 Query: 329 GHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGH 388 ++I D GLA + + V T Y APE++ + Y+ + D +S+GC++ +LL G Sbjct: 191 CELKILDFGLA-RHTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGR 249 Query: 389 SPF 391 + F Sbjct: 250 TLF 252 >5HIE-A nrPDB Length = 302 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 102/219 (46%), Gaps = 26/219 (11%) Query: 191 FSVHRIIGRGGFGEVY-GCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 +V + IG G FG VY G D A+K L ++++ + E L + T Sbjct: 38 ITVGQRIGSGSFGTVYKGKWHGDV----AVKMLTPQQLQAFKNEVGVLRK--------TR 85 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV---FSEADMRFYAAEIILGLE 306 ++ M Y+ T +L+ + G L++HL H + F + A + G++ Sbjct: 86 HVNILLFMGYS--TKPQLAIVTQWCEGSSLYHHL--HIIETKFEMIKLIDIARQTAQGMD 141 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV----GTHGYMAPEV- 361 ++H + +++RDLK NI L E V+I D GLA S+ G+ +MAPEV Sbjct: 142 YLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 201 Query: 362 -LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 399 +Q Y +D ++ G +L++L+ G P+ +D+ Sbjct: 202 RMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ 240 >5ZTN-A nrPDB Length = 429 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/201 (27%), Positives = 99/201 (49%), Gaps = 6/201 (2%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-DKKRIKMKQGETLALNERIMLSLVSTG 249 + V ++IG+G FG+V + A+K + ++KR + E + + E + Sbjct: 99 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT 158 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 + ++ F ++F L MN +L G FS +R +A I+ L+ +H Sbjct: 159 MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQG-FSLPLVRKFAHSILQCLDALH 217 Query: 310 NRFVVYRDLKPANILLDEHGH--VRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVA 367 +++ DLKP NILL + G +++ D G +C + ++ + + + Y APEV+ G Sbjct: 218 KNRIIHCDLKPENILLKQQGRSGIKVIDFGSSC-YEHQRVYTYIQSRFYRAPEVIL-GAR 275 Query: 368 YDSSADWFSLGCMLFKLLRGH 388 Y D +SLGC+L +LL G+ Sbjct: 276 YGMPIDMWSLGCILAELLTGY 296 >4QTB-A nrPDB Length = 380 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 44/148 (29%), Positives = 76/148 (51%), Gaps = 12/148 (8%) Query: 269 FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEH 328 + DLM DL Y L + S + ++ +I+ GL+++H+ V++RDLKP+N+L++ Sbjct: 121 IVQDLMET-DL-YKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTT 178 Query: 329 GHVRISDLGLACDFSKKKPHAS-----VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFK 383 ++I D GLA + H V T Y APE++ Y S D +S+GC+L + Sbjct: 179 CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAE 238 Query: 384 LLRGHSPFRQHKTKDKHEIDRMTLTMAV 411 +L F KH +D++ + + Sbjct: 239 MLSNRPIF-----PGKHYLDQLNHILGI 261 >6J5U-C nrPDB Length = 426 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 97/215 (45%), Gaps = 24/215 (11%) Query: 190 DFSVHRIIGRGGFGEVY---------GCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240 +F ++G GGFG V+ + +G + A+K L + QG L E Sbjct: 85 NFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGF---QGHKEWLTEV 141 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYA 298 L +S + ++ + Y ++L + + M G L HL + G + A A Sbjct: 142 NYLGQLSHPN--LVLLVGYCAEGENRL-LVYEFMPKGSLENHLFRRGAQPLTWAIRMKVA 198 Query: 299 AEIILGLEHMH--NRFVVYRDLKPANILLDEHGHVRISDLGLA-CDFSKKKPHAS---VG 352 GL +H V+YRD K ANILLD + ++SD GLA + H S +G Sbjct: 199 VGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIG 258 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRG 387 THGY APE + G + +D +S G +L +L+ G Sbjct: 259 THGYAAPEYVATG-RLTAKSDVYSFGVVLLELISG 292 >3E7O-A nrPDB Length = 360 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 65/244 (26%), Positives = 116/244 (47%), Gaps = 26/244 (10%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G G V C DT + + KK + Q +T A L L+ + I+ Sbjct: 30 IGSGAQGIV--CAAFDT--VLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIIS 85 Query: 257 MSYAFHTPDK-------LSFILDLMNGGDLHYHLSQ--HGVFSEADMRFYAAEIILGLEH 307 + F TP K + +++LM+ +L Q H M + +++ G++H Sbjct: 86 LLNVF-TPQKTLEEFQDVYLVMELMDA-----NLCQVIHMELDHERMSYLLYQMLCGIKH 139 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHASVGTHGYMAPEVLQK 364 +H+ +++RDLKP+NI++ ++I D GLA S P+ V T Y APEV+ Sbjct: 140 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPY--VVTRYYRAPEVIL- 196 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSFSPELRS 423 G+ Y + D +S+GC++ +L++G F+ D+ +++ T + E + P +R+ Sbjct: 197 GMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRN 256 Query: 424 LLEG 427 +E Sbjct: 257 YVEN 260 >2W96-B nrPDB Length = 306 Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 99/203 (48%), Gaps = 21/203 (10%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE----TLALNERIMLSLVSTGDCP 252 IG G +G VY R +G A+K +++ GE + E +L + + P Sbjct: 12 IGVGAYGTVYKARDPHSGHFVALKS-----VRVPNGEEGLPISTVREVALLRRLEAFEHP 66 Query: 253 FIV-----CMSYAFHTPDKLSFILDLMNGGDLHYHLSQH---GVFSEADMRFYAAEIILG 304 +V C + K++ + + ++ DL +L + G+ +E ++ + + G Sbjct: 67 NVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAET-IKDLMRQFLRG 124 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-HASVGTHGYMAPEVLQ 363 L+ +H +V+RDLKP NIL+ G V+++D GLA +S + V T Y APEVL Sbjct: 125 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVLL 184 Query: 364 KGVAYDSSADWFSLGCMLFKLLR 386 + Y + D +S+GC+ ++ R Sbjct: 185 QS-TYATPVDMWSVGCIFAEMFR 206 >5Y86-A nrPDB Length = 588 Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 103/207 (49%), Gaps = 12/207 (5%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-DKKRIKMKQGETLALNERIMLSLVSTG 249 + V +IIG+G FG+V + A+K + ++KR + E + + E + TG Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLK-KQDKTG 267 Query: 250 DCPFIVCM-SYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEIILGLE 306 I + S+ F ++F L + DL+ + ++ FS +R +A I+ L+ Sbjct: 268 SMNVIHMLESFTFRNHVCMAFELLSI---DLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 Query: 307 HMHNRFVVYRDLKPANILLDEHGH--VRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 364 +H +++ DLKP NILL HG ++ D G +C F +K + + + Y APE++ Sbjct: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-FEYQKLYTYIQSRFYRAPEIIL- 382 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPF 391 G Y + D +S GC+L +LL G F Sbjct: 383 GSRYSTPIDIWSFGCILAELLTGQPLF 409 >4Y83-A nrPDB Length = 332 Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 74/282 (26%), Positives = 121/282 (42%), Gaps = 39/282 (13%) Query: 166 IESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK 225 I+SD WK NI +DF I RG FG+VY + T K A K + Sbjct: 60 IDSDVL--LIPWKLTYRNIG---SDF-----IPRGAFGKVYLAQDIKTKKRMACKLIPVD 109 Query: 226 RIKMKQGETLAL--NERI--MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHY 281 + K E A +E I + V G+ + ++ GG + Sbjct: 110 QFKPSDVEIQACFRHENIAELYGAVLWGET---------------VHLFMEAGEGGSVLE 154 Query: 282 HLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD 341 L G E ++ + ++ GL+ +H++ V++ D+KP+NI+ V + D GL+ Sbjct: 155 KLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLV-DFGLSVQ 213 Query: 342 FSKKK--PHASVGTHGYMAPEV-LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 ++ P GT YM+PEV L +G + + AD +SLG L + G P+ + + Sbjct: 214 MTEDVYFPKDLRGTEIYMSPEVILCRG--HSTKADIYSLGATLIHMQTGTPPWVKRYPRS 271 Query: 399 KHE----IDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + I ++ D SP +R L+E L+R+ N R Sbjct: 272 AYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHR 313 >6HV0-A nrPDB Length = 416 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/182 (31%), Positives = 89/182 (48%), Gaps = 34/182 (18%) Query: 304 GLEHMHNRFVVYRDLKPANILL---DEHGHVR--ISDLGLA-------CDFSKKKPHASV 351 GL H+H+ +V+RDLKP NIL+ + HG ++ ISD GL FS++ Sbjct: 114 GLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRS--GVP 171 Query: 352 GTHGYMAPEVLQKGVAYDS--SADWFSLGCMLFKLL-RGHSPFRQHKTKDKHEIDRMTLT 408 GT G++APE+L + + + D FS GC+ + ++ G PF + + + L Sbjct: 172 GTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQAN-----ILL 226 Query: 409 MAVELPDSFSPE------LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVF 462 A L D PE R L+E ++ D +R A+ V + PFF SL+ Q+ F Sbjct: 227 GACSL-DCLHPEKHEDVIARELIEKMIAMDPQKR-----PSAKHVLKHPFFWSLEKQLQF 280 Query: 463 LQ 464 Q Sbjct: 281 FQ 282 >3LLT-A nrPDB Length = 360 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 71/261 (27%), Positives = 110/261 (42%), Gaps = 43/261 (16%) Query: 165 FIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDK 224 F D+ F K + LN N F V R +G G FG V C+ D K YA+K + Sbjct: 16 FQGDDEIVHFSWKKGMLLN-----NAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRN 70 Query: 225 KRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSY--AFHTPDKLSFILDLMNGGDLHYH 282 +K+ A E +L + D + Y F D + I + + G L+ Sbjct: 71 ----IKKYTRSAKIEADILKKIQNDDINNNNIVKYHGKFMYYDHMCLIFEPL-GPSLYEI 125 Query: 283 LSQHGV--FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDE------------- 327 ++++ F D++ Y EI+ L ++ + + DLKP NILLD+ Sbjct: 126 ITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRV 185 Query: 328 ------------HGHVRISDLGLACDFSKKKPHAS-VGTHGYMAPEVLQKGVAYDSSADW 374 +++ D G C K H S + T Y APEV+ + +D S+D Sbjct: 186 TDGKKIQIYRTKSTGIKLIDFG--CATFKSDYHGSIINTRQYRAPEVIL-NLGWDVSSDM 242 Query: 375 FSLGCMLFKLLRGHSPFRQHK 395 +S GC+L +L G FR H+ Sbjct: 243 WSFGCVLAELYTGSLLFRTHE 263 >5NGU-A nrPDB Length = 381 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 40/133 (30%), Positives = 69/133 (51%), Gaps = 12/133 (9%) Query: 284 SQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS 343 +QH S + ++ +I+ GL+++H+ V++RDLKP+N+LL+ ++I D GLA Sbjct: 137 TQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD 194 Query: 344 KKKPHAS-----VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 H V T Y APE++ Y S D +S+GC+L ++L F Sbjct: 195 PDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF-----PG 249 Query: 399 KHEIDRMTLTMAV 411 KH +D++ + + Sbjct: 250 KHYLDQLNHILGI 262 >6HMD-A nrPDB Length = 365 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 93/204 (45%), Gaps = 44/204 (21%) Query: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKK 346 + ++ D+RFY E++ L++ H++ +++RD+KP N+++D + +R+ D GLA + + Sbjct: 143 ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ 202 Query: 347 PH-ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRM 405 + V + + PE+L YD S D +SLGCML ++ PF H + ++ R+ Sbjct: 203 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFF-HGQDNYDQLVRI 261 Query: 406 TLTMAVE------------LPDSF------------------------SPELRSLLEGLL 429 + E L F SPE LL+ LL Sbjct: 262 AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLL 321 Query: 430 QRDVNRRLGCLGRGAQEVKESPFF 453 + D +RL A+E E P+F Sbjct: 322 RYDHQQRL-----TAKEAMEHPYF 340 >4E7W-A nrPDB Length = 394 Score = 67.0 bits (162), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 100/208 (48%), Gaps = 22/208 (10%) Query: 195 RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 254 ++IG G FG V+ + ++ ++ K L KR K ++ L ++ P + Sbjct: 46 KVIGNGSFGVVFQAKLVESDEVAIKKVLQDKRFKNRE-----------LQIMRIVKHPNV 94 Query: 255 VCMSYAFHT----PDKLSFILDLMNGGDLHYHLSQHGVFSEADM-----RFYAAEIILGL 305 V + F++ D++ L L + Y S+H + M + Y +++ L Sbjct: 95 VDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSL 154 Query: 306 EHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHAS-VGTHGYMAPEVLQ 363 ++H+ + +RD+KP N+LLD G +++ D G A +P+ S + + Y APE++ Sbjct: 155 AYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIF 214 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPF 391 Y ++ D +S GC++ +L++G F Sbjct: 215 GATNYTTNIDIWSTGCVMAELMQGQPLF 242 >1ZXE-A nrPDB Length = 303 Score = 67.0 bits (162), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 67/284 (23%), Positives = 128/284 (45%), Gaps = 44/284 (15%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +DF ++G+G FG+V R A + YA+K + K+ + L+E ++L+ ++ Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKL----STILSEVMLLASLNH 61 Query: 249 GDC-----------PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEAD--MR 295 F+ M+ A L ++ L+ + + + D R Sbjct: 62 QYVVRYYAAWLERRNFVKPMT-AVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWR 120 Query: 296 FYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF----------SKK 345 + +I+ L ++H++ +++R+LKP NI +DE +V+I D GLA + S+ Sbjct: 121 LFR-QILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQN 179 Query: 346 KPHAS------VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 399 P +S +GT Y+A EVL Y+ D +SLG + F+++ PF ++ Sbjct: 180 LPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFST--GMER 234 Query: 400 HEIDRMTLTMAVELPDSFSPEL----RSLLEGLLQRDVNRRLGC 439 I + ++++E P F + ++ L+ D N+R G Sbjct: 235 VNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGA 278 >4PL5-B nrPDB Length = 435 Score = 67.0 bits (162), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 58/182 (31%), Positives = 90/182 (49%), Gaps = 34/182 (18%) Query: 304 GLEHMHNRFVVYRDLKPANILL---DEHGHVR--ISDLGLA-------CDFSKKKPHASV 351 GL H+H+ +V+RDLKP NILL + HG ++ ISD GL FS++ Sbjct: 133 GLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRS--GVP 190 Query: 352 GTHGYMAPEVLQKGVAYDS--SADWFSLGCMLFKLL-RGHSPFRQHKTKDKHEIDRMTLT 408 GT G++APE+L + + + D FS GC+ + ++ G+ PF + + + L Sbjct: 191 GTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQAN-----ILL 245 Query: 409 MAVELPDSFSPE------LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVF 462 A L D F + R L+E ++ D +R A+ V + PFF SL+ Q+ F Sbjct: 246 GACNL-DCFHSDKHEDVIARELIEKMIAMDPQQR-----PSAKHVLKHPFFWSLEKQLQF 299 Query: 463 LQ 464 Q Sbjct: 300 FQ 301 >2QKW-B nrPDB Length = 321 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 99/213 (46%), Gaps = 16/213 (7%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 N+F +IG G FG+VY D K+ L ++ + QG E LS Sbjct: 39 NNFDHKFLIGHGVFGKVYKGVLRDGAKV----ALKRRTPESSQGIEEFETEIETLSFCRH 94 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG---- 304 P +V + +++ I M G+L HL + + + EI +G Sbjct: 95 ---PHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARG 151 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASV---GTHGYMAPE 360 L ++H R +++RD+K NILLDE+ +I+D G++ ++ + H S GT GY+ PE Sbjct: 152 LHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPE 211 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQ 393 KG + S D +S G +LF++L S Q Sbjct: 212 YFIKGRLTEKS-DVYSFGVVLFEVLCARSAIVQ 243 >5TQX-A nrPDB Length = 655 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 102/215 (47%), Gaps = 28/215 (13%) Query: 197 IGRGGFGEV--YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 254 +G GGFG V Y R+ D K+ C + + K E +IM L Sbjct: 16 LGTGGFGNVCLYQHRELDL-KIAIKSC--RLELSTKNRERWCHEIQIMKKLNHAN----- 67 Query: 255 VCMSYAFHTPDKLSFI--------LDLMNGGDLHYHLSQH---GVFSEADMRFYAAEIIL 303 + A P++L+ + ++ +GGDL L++ E+ + ++I Sbjct: 68 --VVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGS 125 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHV---RISDLGLACDFSKKKPHAS-VGTHGYMAP 359 G+ ++H +++RDLKP NI+L + G +I DLG A D + + VGT Y+AP Sbjct: 126 GIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAP 185 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQH 394 E+ + Y ++ D++S G M+F+ + G+ PF H Sbjct: 186 ELFENK-PYTATVDYWSFGTMVFECIAGYRPFLHH 219 >3HMP-A nrPDB Length = 342 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 63/269 (23%), Positives = 122/269 (45%), Gaps = 33/269 (12%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-----DKKRIKMKQGETLALNERIMLSL 245 +S+ + IG GG +V+ + ++YA+K + D + + + E LN+ L Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNK-----L 111 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 D + Y + D+ +++ DL+ L + + + Y ++ + Sbjct: 112 QQHSDK---IIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 168 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC----DFSKKKPHASVGTHGYMAPEV 361 +H +V+ DLKPAN L+ + G +++ D G+A D + + VGT YM PE Sbjct: 169 HTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 227 Query: 362 LQKGVAYDSSA----------DWFSLGCMLFKLLRGHSPFRQ--HKTKDKHEIDRMTLTM 409 ++ + + D +SLGC+L+ + G +PF+Q ++ H I + Sbjct: 228 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAI--IDPNH 285 Query: 410 AVELPDSFSPELRSLLEGLLQRDVNRRLG 438 +E PD +L+ +L+ L+RD +R+ Sbjct: 286 EIEFPDIPEKDLQDVLKCCLKRDPKQRIS 314 >5AP3-A nrPDB Length = 313 Score = 66.6 bits (161), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 63/269 (23%), Positives = 122/269 (45%), Gaps = 33/269 (12%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-----DKKRIKMKQGETLALNERIMLSL 245 +S+ + IG GG +V+ + ++YA+K + D + + + E LN+ L Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNK-----L 83 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 D + Y + D+ +++ DL+ L + + + Y ++ + Sbjct: 84 QQHSDK---IIRLYDYEITDQYIYMVMECGNIDLNGWLKKKKSIDPWERKSYWKNMLEAV 140 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC----DFSKKKPHASVGTHGYMAPEV 361 +H +V+ DLKPAN L+ + G +++ D G+A D + + VGT YM PE Sbjct: 141 HTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 199 Query: 362 LQKGVAYDSSA----------DWFSLGCMLFKLLRGHSPFRQ--HKTKDKHEIDRMTLTM 409 ++ + + D +SLGC+L+ + G +PF+Q ++ H I + Sbjct: 200 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAI--IDPNH 257 Query: 410 AVELPDSFSPELRSLLEGLLQRDVNRRLG 438 +E PD +L+ +L+ L+RD +R+ Sbjct: 258 EIEFPDIPEKDLQDVLKCCLKRDPKQRIS 286 >4CRL-A nrPDB Length = 406 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 103/218 (47%), Gaps = 33/218 (15%) Query: 197 IGRGGFGEVYGCRKADTGKM--YAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 254 +GRG +G VY ++ D YA+K ++ I M +AL + P + Sbjct: 30 VGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLREL--------KHPNV 81 Query: 255 VCMSYAF--HTPDKLSFILDLMNGGDLHYHLSQHGVFSEAD----------MRFYAAEII 302 + + F H K+ + D DL +H+ + S+A+ ++ +I+ Sbjct: 82 ISLQKVFLSHADRKVWLLFDYAEH-DL-WHIIKFHRASKANKKPVQLPRGMVKSLLYQIL 139 Query: 303 LGLEHMHNRFVVYRDLKPANILL----DEHGHVRISDLGLACDF-SKKKPHAS----VGT 353 G+ ++H +V++RDLKPANIL+ E G V+I+D+G A F S KP A V T Sbjct: 140 DGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVT 199 Query: 354 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 Y APE+L Y + D +++GC+ +LL F Sbjct: 200 FWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIF 237 >4NEU-A nrPDB Length = 333 Score = 65.5 bits (158), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 62/229 (27%), Positives = 100/229 (43%), Gaps = 27/229 (11%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 I + +DF + GGFG+V C G M MK + K ++ E L ++M Sbjct: 19 IKMKSSDFLESAELDSGGFGKVSLCFHRTQGLM-IMKTVYKGPNCIEHNEALLEEAKMMN 77 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 L + +V + K S +++ M G+L + L + EII Sbjct: 78 RLRHSR----VVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIE 133 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA------------------CDFSKK 345 G+ ++H + V+++DLKP NIL+D H++I+DLGLA D + K Sbjct: 134 GMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAK 193 Query: 346 KPHASVGTHGYMAPEVLQKGVAYDS-SADWFSLGCMLFKLLRGHSPFRQ 393 K + GT YMAPE L A + +D +S +L+ + P+ Sbjct: 194 K---NGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYEN 239 >4OW8-A nrPDB Length = 283 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 98/215 (45%), Gaps = 24/215 (11%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK---------RIKMKQGETLALNERI 241 + + R+I GG G+V+ G+ A+K L + R + + T LN Sbjct: 13 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 72 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 + S+ G+ A+ +++L+NG L+ L + G S + Sbjct: 73 IASVHDYGESQMNGEGRTAY-------LVMELVNGEPLNSVLKRTGRLSLRHALDMLEQT 125 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGL--ACDFSKKKPHASV-GTHGYMA 358 L+ H +V+RD+KP NIL+ G V+I+D G+ A D + V GT Y+A Sbjct: 126 GRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIA 185 Query: 359 PEVLQKGVAYDSS--ADWFSLGCMLFKLLRGHSPF 391 PE + + +D+S +D +SLG + ++ + G PF Sbjct: 186 PE---QALGHDASPASDVYSLGVVGYEAVSGKRPF 217 >5HVK-A nrPDB Length = 315 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 98/213 (46%), Gaps = 36/213 (16%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 ++G+G FG+ +TG++ MK L R + T ++M L + P ++ Sbjct: 21 VLGKGCFGQAIKVTHRETGEVMVMKEL--IRFDEETQRTFLKEVKVMRCL----EHPNVL 74 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRF-------YAAEIILGLEHM 308 + +L+FI + + GG L G+ D ++ +A +I G+ ++ Sbjct: 75 KFIGVLYKDKRLNFITEYIKGGTLR------GIIKSMDSQYPWSQRVSFAKDIASGMAYL 128 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLACDF----------------SKKKPHASVG 352 H+ +++R+L N L+ E+ +V ++D GLA +KK + VG Sbjct: 129 HSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVG 188 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL 385 +MAPE++ G +YD D FS G +L +++ Sbjct: 189 NPYWMAPEMIN-GRSYDEKVDVFSFGIVLCEII 220 >3OZ6-A nrPDB Length = 388 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/263 (23%), Positives = 118/263 (44%), Gaps = 34/263 (12%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALN--ERIMLSLVSTGDCPFI 254 +G+G +G V+ TG++ A+K K Q T A IM+ +G + Sbjct: 17 LGKGAYGIVWKSIDRRTGEVVAVK----KIFDAFQNSTDAQRTFREIMILTELSGHENIV 72 Query: 255 VCMSYAFHTPDK-LSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFV 313 ++ D+ + + D M DLH + + + ++ ++I ++++H+ + Sbjct: 73 NLLNVLRADNDRDVYLVFDYMET-DLHA-VIRANILEPVHKQYVVYQLIKVIKYLHSGGL 130 Query: 314 VYRDLKPANILLDEHGHVRISDLGLAC---------------------DFSKKKPHAS-- 350 ++RD+KP+NILL+ HV+++D GL+ +F +P + Sbjct: 131 LHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPILTDY 190 Query: 351 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE--IDRMTLT 408 V T Y APE+L Y D +SLGC+L ++L G F T ++ E I + Sbjct: 191 VATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERIIGVIDFP 250 Query: 409 MAVELPDSFSPELRSLLEGLLQR 431 ++ SP ++++E L ++ Sbjct: 251 SNEDVESIQSPFAKTMIESLKEK 273 >4TPT-A nrPDB Length = 303 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 29/212 (13%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 ++G+G FG+ TGK+ MK L R + +T ++M SL D P ++ Sbjct: 7 VLGKGFFGQAIKVTHKATGKVMVMKEL--IRCDEETQKTFLTEVKVMRSL----DHPNVL 60 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 + KL+ + + + GG L L F +A I G+ ++H+ +++ Sbjct: 61 KFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIH 120 Query: 316 RDLKPANILLDEHGHVRISDLGLACDF----------------------SKKKPHASVGT 353 RDL N L+ V ++D GL+ +KK + VG Sbjct: 121 RDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 180 Query: 354 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL 385 +MAPE+L G +YD + D FS G +L +++ Sbjct: 181 PYWMAPEMLN-GKSYDETVDIFSFGIVLCEII 211 >6CTH-A nrPDB Length = 309 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 58/206 (28%), Positives = 96/206 (46%), Gaps = 14/206 (6%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 ++F+ +G GGFG VY D+ A+K + + KQG +E ++S + Sbjct: 15 SNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRAS---KQGIKEYASEVKIISRLRH 71 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYA----AEIILG 304 + +V + H +L + + M G L H+ + ++R+ A +L Sbjct: 72 KN---LVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLY 128 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA--CDFSKK-KPHASVGTHGYMAPEV 361 L + V++RD+K +NI+LD + ++ D GLA D +K K GT GYMAPE Sbjct: 129 LHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPEC 188 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRG 387 L G A S D +S G + ++ G Sbjct: 189 LSSGKASKES-DVYSFGVVALEIASG 213 >3NIE-A nrPDB Length = 429 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 57/231 (24%), Positives = 101/231 (43%), Gaps = 39/231 (16%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM--LSLV 246 +++ + +IGRG +G VY + K A+K +++ E L +RI+ ++++ Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNR------MFEDLIDCKRILREITIL 81 Query: 247 STGDCPFIVCMSYAFHTPDKLSF----ILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 + +I+ + D L F I+ + DL +E ++ ++ Sbjct: 82 NRLKSDYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIFLTEQHVKTILYNLL 141 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK---------------- 346 LG + +H +++RDLKPAN LL++ V+I D GLA + K Sbjct: 142 LGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEE 201 Query: 347 --PH---------ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR 386 PH + V T Y APE++ Y +S D +S GC+ +LL Sbjct: 202 PGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLN 252 >3E3P-A nrPDB Length = 360 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 58/234 (24%), Positives = 112/234 (47%), Gaps = 24/234 (10%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 M+ F V R+ G+G FG V ++ TG A+K K+ Q E ++ ++ Sbjct: 22 MDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIK-------KVIQDPRFRNRELQIMQDLA 74 Query: 248 TGDCPFIVCMSYAFHTPDK-----------LSFILDLMNGGDLHYHLSQHGVFSEADMRF 296 P IV + F+T + + ++ D ++ +Y+ Q ++ Sbjct: 75 VLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAP-PPILIKV 133 Query: 297 YAAEII--LGLEHMHNRFVVYRDLKPANILLDE-HGHVRISDLGLACDFSKKKPH-ASVG 352 + ++I +G H+ + V +RD+KP N+L++E G +++ D G A S +P+ A + Sbjct: 134 FLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYIC 193 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRM 405 + Y APE++ Y ++ D +S+GC+ +++ G FR + + HEI R+ Sbjct: 194 SRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRV 247 >4M66-A nrPDB Length = 325 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 67/242 (27%), Positives = 108/242 (44%), Gaps = 23/242 (9%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLAL-NERIMLSLVSTGDCPFIV 255 +G+GGFG V+ A+K ++ K+I + + L NE ++L L T D Sbjct: 28 VGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVLLLLGVTED----- 82 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH--NRFV 313 + + F + L + M G L L + E++LG+ ++H + + Sbjct: 83 -LQWDFVSGQAL--VTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHSLDPPL 139 Query: 314 VYRDLKPANILLDEHGHVRISDLGLAC--------DFSKKKPHASVGTHGYMAPEVLQK- 364 ++RDLKP+NILLD H +++D GL+ S S GT Y+ PE+L K Sbjct: 140 LHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFKV 199 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI--DRMTLTMAVELPDSFSPELR 422 + ++D +S G +++ +L G KT E DR + ELP SPE Sbjct: 200 NLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTELPPG-SPETP 258 Query: 423 SL 424 L Sbjct: 259 GL 260 >2ZMD-A nrPDB Length = 390 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 62/268 (23%), Positives = 121/268 (45%), Gaps = 33/268 (12%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-----DKKRIKMKQGETLALNERIMLSL 245 +S+ + IG GG +V+ + ++YA+K + D + + + E LN+ L Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNK-----L 111 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 D + Y + D+ +++ DL+ L + + + Y ++ + Sbjct: 112 QQHSDK---IIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 168 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC----DFSKKKPHASVGTHGYMAPEV 361 +H +V+ DLKPAN L+ + G +++ D G+A D + + VG YM PE Sbjct: 169 HTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEA 227 Query: 362 LQKGVAYDSSA----------DWFSLGCMLFKLLRGHSPFRQ--HKTKDKHEIDRMTLTM 409 ++ + + D +SLGC+L+ + G +PF+Q ++ H I + Sbjct: 228 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAI--IDPNH 285 Query: 410 AVELPDSFSPELRSLLEGLLQRDVNRRL 437 +E PD +L+ +L+ L+RD +R+ Sbjct: 286 EIEFPDIPEKDLQDVLKCCLKRDPKQRI 313 >2A1A-B nrPDB Length = 284 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 94/208 (45%), Gaps = 16/208 (7%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 DF +IG GGFG+V+ + GK Y +K + K ++ E AL + +++V Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAER-EVKALAKLDHVNIVHYN 70 Query: 250 DC-------PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE-- 300 C P + + L ++ + G L + + E + A E Sbjct: 71 GCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRR--GEKLDKVLALELF 128 Query: 301 --IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK-KPHASVGTHGYM 357 I G++++H++ ++ RDLKP+NI L + V+I D GL K S GT YM Sbjct: 129 EQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYM 188 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLL 385 +PE + Y D ++LG +L +LL Sbjct: 189 SPEQIS-SQDYGKEVDLYALGLILAELL 215 >4HVI-A nrPDB Length = 314 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 95/201 (47%), Gaps = 19/201 (9%) Query: 197 IGRGGFGEVYGCR----KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 +G+G FG V CR +TG + A+K L Q +I+ +L S Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS--GPDQQRDFQREIQILKALHSD---- 71 Query: 253 FIVCMSYAFHTPDK--LSFILDLMNGGDLHYHLSQHGVFSEAD-MRFYAAEIILGLEHMH 309 FIV + P + L +++ + G L L +H +A + Y+++I G+E++ Sbjct: 72 FIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLG 131 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPEVLQK 364 +R V+RDL NIL++ HV+I+D GLA K + V G + APE L Sbjct: 132 SRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSD 191 Query: 365 GVAYDSSADWFSLGCMLFKLL 385 + + +D +S G +L++L Sbjct: 192 NI-FSRQSDVWSFGVVLYELF 211 >4X3F-A nrPDB Length = 337 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 98/215 (45%), Gaps = 24/215 (11%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK---------RIKMKQGETLALNERI 241 + + R+I GG G+V+ G+ A+K L + R + + T LN Sbjct: 14 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 73 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 + S+ G+ A+ +++L+NG L+ L + G S + Sbjct: 74 IASVHDYGESQMNGEGRTAY-------LVMELVNGEPLNSVLKRTGRLSLRHALDMLEQT 126 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGL--ACDFSKKKPHASV-GTHGYMA 358 L+ H +V+RD+KP NIL+ G V+I+D G+ A D + V GT Y+A Sbjct: 127 GRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIA 186 Query: 359 PEVLQKGVAYDSS--ADWFSLGCMLFKLLRGHSPF 391 PE + + +D+S +D +SLG + ++ + G PF Sbjct: 187 PE---QALGHDASPASDVYSLGVVGYEAVSGKRPF 218 >2PVN-A nrPDB Length = 352 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 38/126 (30%), Positives = 68/126 (53%), Gaps = 5/126 (3%) Query: 268 SFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD- 326 S I + +N D + ++ D+R+Y E++ L++ H++ +++RD+KP N+++D Sbjct: 125 SLIFEYVNNTDFK---VLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDH 181 Query: 327 EHGHVRISDLGLACDFSKKKPH-ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL 385 E +R+ D GLA + K + V + + PE+L YD S D +SLGCM ++ Sbjct: 182 ELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMI 241 Query: 386 RGHSPF 391 PF Sbjct: 242 FRKEPF 247 >6B2Q-A nrPDB Length = 317 Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 98/215 (45%), Gaps = 24/215 (11%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK---------RIKMKQGETLALNERI 241 + + R+I GG G+V+ G+ A+K L + R + + T LN Sbjct: 34 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 93 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 + S+ G+ A+ +++L+NG L+ L + G S + Sbjct: 94 IASVHDYGESQMNGEGRTAY-------LVMELVNGEPLNSVLKRTGRLSLRHALDMLEQT 146 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGL--ACDFSKKKPHASV-GTHGYMA 358 L+ H +V+RD+KP NIL+ G V+I+D G+ A D + V GT Y+A Sbjct: 147 GRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIA 206 Query: 359 PEVLQKGVAYDSS--ADWFSLGCMLFKLLRGHSPF 391 PE + + +D+S +D +SLG + ++ + G PF Sbjct: 207 PE---QALGHDASPASDVYSLGVVGYEAVSGKRPF 238 >5VC6-A nrPDB Length = 289 Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 71/263 (26%), Positives = 113/263 (42%), Gaps = 33/263 (12%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G FG V+ C K G +YA+K KK + E AL E +++ G +V Sbjct: 19 IGSGEFGSVFKCVKRLDGCIYAIK-RSKKPLAGSVDEQNALREVYAHAVL--GQHSHVVR 75 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQH----GVFSEADMRFYAAEIILGLEHMHNRF 312 A+ D + + NGG L +S++ F EA+++ ++ GL ++H+ Sbjct: 76 YFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMS 135 Query: 313 VVYRDLKPANILL---------DEHGH----------VRISDLGLACDFSKKKPHASVGT 353 +V+ D+KP+NI + E G +I DLG S P G Sbjct: 136 LVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRIS--SPQVEEGD 193 Query: 354 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVEL 413 ++A EVLQ+ + AD F+L + G P ++ + HEI + L + Sbjct: 194 SRFLANEVLQENYTHLPKADIFALALTVV-CAAGAEPLPRNGDQ-WHEIRQGRLP---RI 248 Query: 414 PDSFSPELRSLLEGLLQRDVNRR 436 P S E LL+ ++ D RR Sbjct: 249 PQVLSQEFTELLKVMIHPDPERR 271 >5O0Y-A nrPDB Length = 579 Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 46/167 (27%), Positives = 82/167 (49%), Gaps = 20/167 (11%) Query: 250 DCPFIVCMSYAFHTPDKLSF--ILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 D P IV + Y + + D SF +L+ G DL ++L QH + SE + R +I+ L++ Sbjct: 346 DHPRIVKL-YDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKY 404 Query: 308 MH--NRFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKKPHA---------SVGT 353 ++ +++ DLKP NILL G ++I+D GL+ ++ GT Sbjct: 405 LNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGT 464 Query: 354 HGYMAPEVLQKGV---AYDSSADWFSLGCMLFKLLRGHSPFRQHKTK 397 + Y+ PE G + D +S+G + ++ L G PF ++++ Sbjct: 465 YWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQ 511 >3MIA-A nrPDB Length = 351 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 66/241 (27%), Positives = 116/241 (48%), Gaps = 29/241 (12%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKM---KQGETL-ALNERIMLSLVSTGDCP 252 IG+G FGEV+ R TG+ A+K ++ M K+G + AL E +L L+ + Sbjct: 25 IGQGTFGEVFKARHRKTGQKVALK-----KVLMENEKEGFPITALREIKILQLLKHENVV 79 Query: 253 FIVCMSYAFHTP-----DKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLE 306 ++ + +P + + D DL LS V F+ ++++ ++ GL Sbjct: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK---PH---ASVGTHGYMAPE 360 ++H +++RD+K AN+L+ G ++++D GLA FS K P+ V T Y PE Sbjct: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 +L Y D + GC++ ++ SP Q T ++H+ L + +L S +PE Sbjct: 199 LLLGERDYGPPIDLWGAGCIMAEMW-TRSPIMQGNT-EQHQ-----LALISQLCGSITPE 251 Query: 421 L 421 + Sbjct: 252 V 252 >3Q4U-A nrPDB Length = 301 Score = 62.8 bits (151), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 98/216 (45%), Gaps = 25/216 (11%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 D ++ +G+G +GEV+ R + G+ A+K + K ET N ++ G Sbjct: 9 DITLLECVGKGRYGEVW--RGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILG 66 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 FI + H+ +L I G L+ +L + + + +R + I GL H+H Sbjct: 67 ---FIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLS-IASGLAHLH 122 Query: 310 NRF--------VVYRDLKPANILLDEHGHVRISDLGLACDFSKKK------PHASVGTHG 355 + +RDLK NIL+ ++G I+DLGLA S+ + VGT Sbjct: 123 IEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKR 182 Query: 356 YMAPEVLQKGVAYDS-----SADWFSLGCMLFKLLR 386 YMAPEVL + + D D ++ G +L+++ R Sbjct: 183 YMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVAR 218 >3HNG-A nrPDB Length = 360 Score = 62.8 bits (151), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 43/149 (28%), Positives = 75/149 (50%), Gaps = 7/149 (4%) Query: 293 DMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG 352 D+ Y+ ++ G+E + +R ++RDL NILL E+ V+I D GLA D K + G Sbjct: 200 DLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKG 259 Query: 353 TH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTL 407 +MAPE + + Y + +D +S G +L+++ G SP+ + D+ R+ Sbjct: 260 DTRLPLKWMAPESIFDKI-YSTKSDVWSYGVLLWEIFSLGGSPYPGVQM-DEDFCSRLRE 317 Query: 408 TMAVELPDSFSPELRSLLEGLLQRDVNRR 436 M + P+ +PE+ ++ RD R Sbjct: 318 GMRMRAPEYSTPEIYQIMLDCWHRDPKER 346 >2H34-A nrPDB Length = 309 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 61/250 (24%), Positives = 107/250 (42%), Gaps = 23/250 (9%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA----LNERIMLSLV 246 + + R++GRGG G+VY ++ A+K + ETL+ R+ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMS---------ETLSSDPVFRTRMQREAR 86 Query: 247 STGDC--PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 + G P +V + +L + L+NG DL L + G + +I Sbjct: 87 TAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSA 146 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA---SVGTHGYMAPEV 361 L+ H +RD+KP NIL+ + D G+A + +K +VGT YMAPE Sbjct: 147 LDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPER 206 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 + A AD ++L C+L++ L G P++ D+ + + A+ P + P + Sbjct: 207 FSESHA-TYRADIYALTCVLYECLTGSPPYQ----GDQLSVMGAHINQAIPRPSTVRPGI 261 Query: 422 RSLLEGLLQR 431 + ++ R Sbjct: 262 PVAFDAVIAR 271 >1PY5-A nrPDB Length = 326 Score = 62.4 bits (150), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 63/214 (29%), Positives = 98/214 (45%), Gaps = 35/214 (16%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKK--RIKMKQGE---TLALNERIMLSLVSTGDC 251 IG+G FGEV+ R G+ A+K + R ++ E T+ L +L Sbjct: 37 IGKGRFGEVW--RGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILG------- 87 Query: 252 PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNR 311 FI + T +L + D G L +L+++ V E ++ A GL H+H Sbjct: 88 -FIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKL-ALSTASGLAHLHME 145 Query: 312 FV--------VYRDLKPANILLDEHGHVRISDLGLAC------DFSKKKPHASVGTHGYM 357 V +RDLK NIL+ ++G I+DLGLA D P+ VGT YM Sbjct: 146 IVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYM 205 Query: 358 APEVLQKGVA---YDS--SADWFSLGCMLFKLLR 386 APEVL + ++S AD +++G + +++ R Sbjct: 206 APEVLDDSINMKHFESFKRADIYAMGLVFWEIAR 239 >5X5O-A nrPDB Length = 310 Score = 62.4 bits (150), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 101/216 (46%), Gaps = 24/216 (11%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + + +D G G FG VY + K A+K K +K+++ E +L Sbjct: 10 VQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVK----KLLKIEK-------EAEIL 58 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRF---YAAE 300 S++S + I+ P + + + G L+ +++ + E DM +A + Sbjct: 59 SVLSHRN---IIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATD 114 Query: 301 IILGLEHMHNRF---VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHGY 356 + G+ ++H V++RDLK N+++ G ++I D G A F H S VGT + Sbjct: 115 VAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFG-ASRFHNHTTHMSLVGTFPW 173 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR 392 MAPEV+Q + + D +S G +L+++L PF+ Sbjct: 174 MAPEVIQ-SLPVSETCDTYSYGVVLWEMLTREVPFK 208 >2WO6-A nrPDB Length = 382 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 60/233 (25%), Positives = 111/233 (47%), Gaps = 21/233 (9%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 M+ + + +IG+G FG+V + A+K + K+ + Q + E +L L++ Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI----EVRLLELMN 108 Query: 248 TGDCP---FIVCMSYAFHTPDKLSFILDLM--NGGDLHYHLSQHGVFSEADMRFYAAEII 302 D +IV + F + L + +++ N DL + + GV S R +A ++ Sbjct: 109 KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGV-SLNLTRKFAQQMC 167 Query: 303 LGLEHMHN--RFVVYRDLKPANILL--DEHGHVRISDLGLACDFSKKKPHASVGTHGYMA 358 L + +++ DLKP NILL + ++I D G +C ++ + + + Y + Sbjct: 168 TALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRS 226 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV 411 PEVL G+ YD + D +SLGC+L ++ G F +E+D+M + V Sbjct: 227 PEVLL-GMPYDLAIDMWSLGCILVEMHTGEPLF-----SGANEVDQMNKIVEV 273 >3PG1-A nrPDB Length = 362 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 97/221 (43%), Gaps = 14/221 (6%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADT-GKMYAMKCL-----DKKRIKMKQGETLAL 237 +H + ++V R I G +G V C D+ G A+K + D + + + L Sbjct: 17 LHAMQSPYTVQRFISSGSYGAV--CAGVDSEGIPVAIKRVFNTVSDGRTVNILSDSFLCK 74 Query: 238 NERIMLSLVSTGDCPFIVCMS---YAFHTP--DKLSFILDLMNGGDLHYHLSQHGVFSEA 292 + L++ P I+ + F P KL + +LM Q V S Sbjct: 75 RVLREIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQ 134 Query: 293 DMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG 352 ++++ I+LGL +H VV+RDL P NILL ++ + I D LA + + Sbjct: 135 HIQYFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYV 194 Query: 353 TH-GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR 392 TH Y APE++ + + D +S GC++ ++ + FR Sbjct: 195 THRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFR 235 >5UIU-A nrPDB Length = 323 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 96/215 (44%), Gaps = 31/215 (14%) Query: 197 IGRGGFGEVYGCRKADTG----KMYAMKCLDKKRIKMKQGETLALNERI-------MLSL 245 +G GGFG VY +T K+ AM + + +K + + + + + +L Sbjct: 55 MGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGF 114 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE-IILG 304 S GD +C+ Y + L LD ++ D LS H MR A+ G Sbjct: 115 SSDGDD---LCLVYVYMPNGSL---LDRLSCLDGTPPLSWH-------MRCKIAQGAANG 161 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS----VGTHGYMAPE 360 + +H ++RD+K ANILLDE +ISD GLA K VGT YMAPE Sbjct: 162 INFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPE 221 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHK 395 L+ + S D +S G +L +++ G +H+ Sbjct: 222 ALRGEITPKS--DIYSFGVVLLEIITGLPAVDEHR 254 >4E93-A nrPDB Length = 377 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 95/223 (42%), Gaps = 14/223 (6%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 L D + IGRG FGEV+ R +AD + C + +K L E +L Sbjct: 111 LNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLK---AKFLQEARILK 167 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIIL 303 S P IV + + +++L+ GGD L G + + Sbjct: 168 QYSH---PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAA 224 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH----GYMAP 359 G+E++ ++ ++RDL N L+ E ++ISD G++ + + AS G + AP Sbjct: 225 GMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAP 284 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHE 401 E L G Y S +D +S G +L++ G SP+ + E Sbjct: 285 EALNYG-RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTRE 326 >2WTK-C nrPDB Length = 305 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 44/181 (24%), Positives = 86/181 (47%), Gaps = 22/181 (12%) Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF----SKKKPHASVG 352 Y ++I GLE++H++ +V++D+KP N+LL G ++IS LG+A + S G Sbjct: 114 YFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQG 173 Query: 353 THGYMAPEVLQKGVAYDS-SADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV 411 + + PE+ + D +S G L+ + G PF + + +++ + Sbjct: 174 SPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPF---EGDNIYKLFENIGKGSY 230 Query: 412 ELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLI 471 +P P L LL+G+L+ + +R +++++ +FR +K+PP Sbjct: 231 AIPGDCGPPLSDLLKGMLEYEPAKRFSI-----RQIRQHSWFR---------KKHPPAEA 276 Query: 472 P 472 P Sbjct: 277 P 277 >3CJF-A nrPDB Length = 309 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 69/251 (27%), Positives = 112/251 (44%), Gaps = 35/251 (13%) Query: 197 IGRGGFGEV-----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL---VST 248 +GRG FG+V +G K T + A+K L K+G T + + +M L + Sbjct: 35 LGRGAFGQVIEADAFGIDKTATCRTVAVKML-------KEGATHSEHRALMSELKILIHI 87 Query: 249 GDCPFIVCMSYAFHTPD-KLSFILDLMNGGDLHYHL-SQHGVF-----------SEADMR 295 G +V + A P L I++ G+L +L S+ F + + Sbjct: 88 GHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLI 147 Query: 296 FYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH- 354 Y+ ++ G+E + +R ++RDL NILL E V+I D GLA D K + G Sbjct: 148 CYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDAR 207 Query: 355 ---GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMA 410 +MAPE + V Y +D +S G +L+++ G SP+ K D+ R+ Sbjct: 208 LPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPGVKI-DEEFCRRLKEGTR 265 Query: 411 VELPDSFSPEL 421 + PD +PE+ Sbjct: 266 MRAPDYTTPEM 276 >3DLS-A nrPDB Length = 335 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 58/255 (22%), Positives = 110/255 (43%), Gaps = 23/255 (9%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI-------KMKQGETLALNERIML 243 +S +G G FG V+ + K +K + K+++ K G+ + + Sbjct: 26 YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKV-----TLEI 80 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGG-DLHYHLSQHGVFSEADMRFYAAEII 302 +++S + I+ + F +++ G DL + +H E + +++ Sbjct: 81 AILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLV 140 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-HASVGTHGYMAPEV 361 + ++ + +++RD+K NI++ E +++ D G A + K + GT Y APEV Sbjct: 141 SAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEV 200 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 L + +SLG L+ L+ +PF + + T+ A+ P S EL Sbjct: 201 LMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEE---------TVEAAIHPPYLVSKEL 251 Query: 422 RSLLEGLLQRDVNRR 436 SL+ GLLQ RR Sbjct: 252 MSLVSGLLQPVPERR 266 >5AWM-A nrPDB Length = 394 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 32/97 (32%), Positives = 59/97 (60%), Gaps = 6/97 (6%) Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHAS 350 M + +++ G++H+H+ +++RDLKP+NI++ ++I D GLA P+ Sbjct: 148 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPY-- 205 Query: 351 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRG 387 V T Y APEV+ G+ Y + D +S+GC++ +++RG Sbjct: 206 VVTRYYRAPEVI-LGMGYTENVDIWSVGCIMGEMIRG 241 >1NY3-A nrPDB Length = 400 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 65/269 (24%), Positives = 123/269 (45%), Gaps = 33/269 (12%) Query: 188 MNDFSV-HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 ++D+ V +++G G G+V T + +A+K L ++ E L+ R Sbjct: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---LHWR------ 110 Query: 247 STGDCPFIVCMSYAFHT----PDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAE 300 CP IV + + L +++ ++GG+L + G F+E + Sbjct: 111 -ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDE---HGHVRISDLGLACDFSKKKPHASVGTHGY- 356 I ++++H+ + +RD+KP N+L + ++++D G A + + H S+ T Y Sbjct: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS---HNSLTTPCYT 226 Query: 357 ---MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA-VE 412 +APEVL YD S D +SLG +++ LL G+ PF + + + M E Sbjct: 227 PYYVAPEVLGPE-KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 Query: 413 LPD----SFSPELRSLLEGLLQRDVNRRL 437 P+ S E++ L+ LL+ + +R+ Sbjct: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRM 314 >2OZA-A nrPDB Length = 356 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 65/269 (24%), Positives = 123/269 (45%), Gaps = 33/269 (12%) Query: 188 MNDFSV-HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 ++D+ V +++G G G+V T + +A+K L ++ E L+ R Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---LHWR------ 66 Query: 247 STGDCPFIVCMSYAFHT----PDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAE 300 CP IV + + L +++ ++GG+L + G F+E + Sbjct: 67 -ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 125 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDE---HGHVRISDLGLACDFSKKKPHASVGTHGY- 356 I ++++H+ + +RD+KP N+L + ++++D G A + + H S+ T Y Sbjct: 126 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS---HNSLTTPCYT 182 Query: 357 ---MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA-VE 412 +APEVL YD S D +SLG +++ LL G+ PF + + + M E Sbjct: 183 PYYVAPEVLGPE-KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 241 Query: 413 LPD----SFSPELRSLLEGLLQRDVNRRL 437 P+ S E++ L+ LL+ + +R+ Sbjct: 242 FPNPEWSEVSEEVKMLIRNLLKTEPTQRM 270 >3UIU-A nrPDB Length = 306 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 93/227 (40%), Gaps = 41/227 (18%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 DF +IG GGFG+V+ + GK Y ++ + K ++ E AL + +++V Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAER-EVKALAKLDHVNIVHYN 71 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE--------- 300 C Y T D D + D S++ S+ F E Sbjct: 72 GC--WDGFDYDPETSD------DSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQ 123 Query: 301 ---------------------IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA 339 I G++++H++ +++RDLKP+NI L + V+I D GL Sbjct: 124 WIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLV 183 Query: 340 CDFSKK-KPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL 385 K S GT YM+PE + Y D ++LG +L +LL Sbjct: 184 TSLKNDGKRTRSKGTLRYMSPEQIS-SQDYGKEVDLYALGLILAELL 229 >1TKI-A nrPDB Length = 321 Score = 60.5 bits (145), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 48/199 (24%), Positives = 97/199 (48%), Gaps = 12/199 (6%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +GRG FG V+ C + + K Y K +K+K + + + + I S+++ I+ Sbjct: 13 LGRGEFGIVHRCVETSSKKTYMAKF-----VKVKGTDQVLVKKEI--SILNIARHRNILH 65 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEHMHNRFVVY 315 + +F + ++L I + ++G D+ ++ +E ++ Y ++ L+ +H+ + + Sbjct: 66 LHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGH 125 Query: 316 RDLKPANILLDEH--GHVRISDLGLACDFSKKKPHASVGTH-GYMAPEVLQKGVAYDSSA 372 D++P NI+ ++I + G A + T Y APEV Q V ++ Sbjct: 126 FDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVV-STAT 184 Query: 373 DWFSLGCMLFKLLRGHSPF 391 D +SLG +++ LL G +PF Sbjct: 185 DMWSLGTLVYVLLSGINPF 203 >3KA0-A nrPDB Length = 320 Score = 60.5 bits (145), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 65/269 (24%), Positives = 123/269 (45%), Gaps = 33/269 (12%) Query: 188 MNDFSV-HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 ++D+ V +++G G G+V T + +A+K L ++ E L+ R Sbjct: 14 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---LHWR------ 64 Query: 247 STGDCPFIVCMSYAFHT----PDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAE 300 CP IV + + L +++ ++GG+L + G F+E + Sbjct: 65 -ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 123 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDE---HGHVRISDLGLACDFSKKKPHASVG----T 353 I ++++H+ + +RD+KP N+L + ++++D G A + + H S+ T Sbjct: 124 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS---HNSLTEPCYT 180 Query: 354 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA-VE 412 Y+APEVL YD S D +SLG +++ LL G+ PF + + + M E Sbjct: 181 PYYVAPEVLGPE-KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 239 Query: 413 LPD----SFSPELRSLLEGLLQRDVNRRL 437 P+ S E++ L+ LL+ + +R+ Sbjct: 240 FPNPEWSEVSEEVKMLIRNLLKTEPTQRM 268 >2XS0-A nrPDB Length = 386 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 38/137 (27%), Positives = 72/137 (52%), Gaps = 5/137 (3%) Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VG 352 M + +++ G++H+H+ +++RDLKP+NI++ ++I D GLA V Sbjct: 130 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVV 189 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHS--PFRQHKTKDKHEIDRMTLTMA 410 T Y APEV+ G+ Y + D +S+GC++ ++++G P H + I+++ T Sbjct: 190 TRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLG-TPC 247 Query: 411 VELPDSFSPELRSLLEG 427 E P +R+ +E Sbjct: 248 PEFMKKLQPTVRTYVEN 264 >3HKO-A nrPDB Length = 345 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 46/153 (30%), Positives = 71/153 (46%), Gaps = 14/153 (9%) Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHG--HVRISDLGLACDFSKKKP------HASV 351 +I L ++HN+ + +RD+KP N L + +++ D GL+ +F K Sbjct: 176 QIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKA 235 Query: 352 GTHGYMAPEVLQ-KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDR-MTLTM 409 GT ++APEVL +Y D +S G +L LL G PF D I + + + Sbjct: 236 GTPYFVAPEVLNTTNESYGPKCDAWSAGVLLHLLLMGAVPFP--GVNDADTISQVLNKKL 293 Query: 410 AVELP--DSFSPELRSLLEGLLQRDVNRRLGCL 440 E P + SP R LL LL R+V+ R + Sbjct: 294 CFENPNYNVLSPLARDLLSNLLNRNVDERFDAM 326 >4JLC-A nrPDB Length = 657 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 51/219 (23%), Positives = 97/219 (44%), Gaps = 32/219 (14%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKR------IKMKQGETLA-LNERIMLSLVST 248 I+G+G V+ R TG +YA+K + ++M++ E L LN + ++ L + Sbjct: 15 ILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 74 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL---SQHGVFSEADMRFYAAEIILGL 305 + T I++ G L+ L S E++ +++ G+ Sbjct: 75 EEET----------TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 124 Query: 306 EHMHNRFVVYRDLKPANIL--LDEHGH--VRISDLGLACDFSKKKPHASV-GTHGYMAPE 360 H+ +V+RD+KP NI+ + E G +++D G A + + S+ GT Y+ P+ Sbjct: 125 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 184 Query: 361 VLQKGV-------AYDSSADWFSLGCMLFKLLRGHSPFR 392 + ++ V Y ++ D +S+G + G PFR Sbjct: 185 MYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFR 223 >3PLS-A nrPDB Length = 298 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 60/212 (28%), Positives = 101/212 (47%), Gaps = 20/212 (9%) Query: 195 RIIGRGGFGEVYGCRKADTGK---MYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDC 251 R+IG+G FG VY D + A+K L + +M+Q E +M L + Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRI-TEMQQVEAFLREGLLMRGL----NH 81 Query: 252 PFIVCMSYAFHTPDKLSFIL-DLMNGGDL-HYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 P ++ + P+ L +L M GDL + S + D+ + ++ G+E++ Sbjct: 82 PNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLA 141 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH-------GYMAPEVL 362 + V+RDL N +LDE V+++D GLA D ++ + SV H + A E L Sbjct: 142 EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDRE-YYSVQQHRHARLPVKWTALESL 200 Query: 363 QKGVAYDSSADWFSLGCMLFKLL-RGHSPFRQ 393 Q + + +D +S G +L++LL RG P+R Sbjct: 201 QT-YRFTTKSDVWSFGVLLWELLTRGAPPYRH 231 >3SOC-A nrPDB Length = 322 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 11/133 (8%) Query: 260 AFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLK 319 AFH LS D + + ++ H + A Y E I GL+ H + +RD+K Sbjct: 102 AFHEKGSLS---DFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIK 158 Query: 320 PANILLDEHGHVRISDLGLACDFSKKKP----HASVGTHGYMAPEVLQKGVAYDSSA--- 372 N+LL + I+D GLA F K H VGT YMAPEVL+ + + A Sbjct: 159 SKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLR 218 Query: 373 -DWFSLGCMLFKL 384 D +++G +L++L Sbjct: 219 IDMYAMGLVLWEL 231 >1JNK-A nrPDB Length = 423 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 31/96 (32%), Positives = 58/96 (60%), Gaps = 6/96 (6%) Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHAS 350 M + +++ G++H+H+ +++RDLKP+NI++ ++I D GLA P+ Sbjct: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY-- 223 Query: 351 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR 386 V T Y APEV+ G+ Y + D +S+GC++ +++R Sbjct: 224 VVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR 258 >3AOX-A nrPDB Length = 344 Score = 58.9 bits (141), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 57/232 (24%), Positives = 105/232 (45%), Gaps = 26/232 (11%) Query: 190 DFSVHRIIGRGGFGEVY-----GCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 + ++ R +G G FGEVY G + A+K L + + +Q E L E +++S Sbjct: 48 NITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPE--VCSEQDELDFLMEALIIS 105 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL-------SQHGVFSEADMRFY 297 + + + C+ + + + +L+LM GGDL L SQ + D+ Sbjct: 106 KFNHQN--IVRCIGVSLQSLPRF-ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHV 162 Query: 298 AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVR---ISDLGLACDFSK----KKPHAS 350 A +I G +++ ++RD+ N LL G R I D G+A D + +K + Sbjct: 163 ARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCA 222 Query: 351 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHE 401 + +M PE +G+ + S D +S G +L+++ G+ P+ ++ E Sbjct: 223 MLPVKWMPPEAFMEGI-FTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLE 273 >3FI2-A nrPDB Length = 353 Score = 58.9 bits (141), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 31/96 (32%), Positives = 58/96 (60%), Gaps = 6/96 (6%) Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHAS 350 M + +++ G++H+H+ +++RDLKP+NI++ ++I D GLA P+ Sbjct: 128 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY-- 185 Query: 351 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR 386 V T Y APEV+ G+ Y + D +S+GC++ +++R Sbjct: 186 VVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR 220 >3MDY-A nrPDB Length = 337 Score = 58.9 bits (141), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 42/140 (30%), Positives = 68/140 (48%), Gaps = 20/140 (14%) Query: 266 KLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF--------VVYRD 317 +L I D G L+ +L + +++ ++ A + GL H+H + +RD Sbjct: 109 QLYLITDYHENGSLYDYLKSTTLDAKSMLKL-AYSSVSGLCHLHTEIFSTQGKPAIAHRD 167 Query: 318 LKPANILLDEHGHVRISDLGLACDFSKKK------PHASVGTHGYMAPEVLQKGVAYDS- 370 LK NIL+ ++G I+DLGLA F P+ VGT YM PEVL + + + Sbjct: 168 LKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHF 227 Query: 371 ----SADWFSLGCMLFKLLR 386 AD +S G +L+++ R Sbjct: 228 QSYIMADMYSFGLILWEVAR 247 >4M7I-A nrPDB Length = 299 Score = 58.5 bits (140), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 63/230 (27%), Positives = 103/230 (44%), Gaps = 41/230 (17%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM--LSL 245 + DF + +GRGGFG V+ + YA+K RI++ E LA E++M + Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIK-----RIRLPNRE-LA-REKVMREVKA 56 Query: 246 VSTGDCPFIVCMSYAF---HTPDKLS---------FILDLMNGGDLHYHLSQHGVFSEAD 293 ++ + P IV A+ +T +KL + L +L ++ E + Sbjct: 57 LAKLEHPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERE 116 Query: 294 MRFYAAEIIL----GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA 349 R I L +E +H++ +++RDLKP+NI V++ D GL + + Sbjct: 117 -RSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQ 175 Query: 350 S--------------VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL 385 + VGT YM+PE + G +Y D FSLG +LF+LL Sbjct: 176 TVLTPMPAYARHTGQVGTKLYMSPEQIH-GNSYSHKVDIFSLGLILFELL 224 >2W1I-A nrPDB Length = 326 Score = 58.5 bits (140), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 67/268 (25%), Positives = 117/268 (43%), Gaps = 37/268 (13%) Query: 197 IGRGGFGEVYGCR----KADTGKMYAMKCLDKKRIKMKQGETLALNER---IMLSLVSTG 249 +G+G FG V CR + +TG++ A+K +++ E L ER I+ SL Sbjct: 49 LGKGNFGSVEMCRYDPLQDNTGEVVAVK-----KLQHSTEEHLRDFEREIEILKSLQHDN 103 Query: 250 DCPFI-VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIILGLEH 307 + VC S L I++ + G L +L +H + Y ++I G+E+ Sbjct: 104 IVKYKGVCYSAGRRN---LKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEY 160 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPEVL 362 + + ++RDL NIL++ V+I D GL + K + V G + APE L Sbjct: 161 LGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESL 220 Query: 363 QKGVAYDSSADWFSLGCMLFKLL----RGHSP---FRQHKTKDK-------HEIDRMTLT 408 + + ++D +S G +L++L + SP F + DK H I+ + Sbjct: 221 TES-KFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNN 279 Query: 409 MAVELPDSFSPELRSLLEGLLQRDVNRR 436 + PD E+ ++ +VN+R Sbjct: 280 GRLPRPDGCPDEIYMIMTECWNNNVNQR 307 >5VO2-A nrPDB Length = 300 Score = 58.5 bits (140), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 41/133 (30%), Positives = 65/133 (48%), Gaps = 11/133 (8%) Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHG 355 ++ I G+ ++H +++RDLK N+L+ V+ISD G + + S K S GT Sbjct: 105 WSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVA 164 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI------DRMTLTM 409 +MAPEV+ + D +S G +L++LL G P+ K D I + + L + Sbjct: 165 WMAPEVI-RNEPVSEKVDIWSFGVVLWELLTGEIPY---KDVDSSAIIWGVGSNSLHLPV 220 Query: 410 AVELPDSFSPELR 422 PD F LR Sbjct: 221 PSSCPDGFKILLR 233 >3GC0-A nrPDB Length = 329 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 53/198 (26%), Positives = 92/198 (46%), Gaps = 16/198 (8%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM-LSLVSTGDCPFIV 255 +G G +GEVY T + A+K RI+++ E I +SL+ I+ Sbjct: 42 LGEGTYGEVYKAIDTVTNETVAIK-----RIRLEHEEEGVPGTAIREVSLLKELQHRNII 96 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 + H +L I + DL ++ ++ S ++ + ++I G+ H+R ++ Sbjct: 97 ELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHSRRCLH 155 Query: 316 RDLKPANILL-----DEHGHVRISDLGLACDFS---KKKPHASVGTHGYMAPEVLQKGVA 367 RDLKP N+LL E ++I D GLA F ++ H + T Y PE+L Sbjct: 156 RDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEII-TLWYRPPEILLGSRH 214 Query: 368 YDSSADWFSLGCMLFKLL 385 Y +S D +S+ C+ ++L Sbjct: 215 YSTSVDIWSIACIWAEML 232 >6DC0-A nrPDB Length = 292 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 53/191 (27%), Positives = 84/191 (43%), Gaps = 25/191 (13%) Query: 277 GDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL--DEHGHVRIS 334 GD+H ++ E + +I+ + H H +V DLK + +E +R+ Sbjct: 82 GDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLE 141 Query: 335 DLGLACDFSKKKPHASVGTHG---YMAPEVLQKGVAYDS-SADWFSLGCMLFKLLRGHSP 390 L K + A HG Y++PE+L Y +AD +SLG ML+ LL G P Sbjct: 142 SLE-DTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYP 200 Query: 391 FRQHKTKDKHEIDRMTLTMAVE-----LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQ 445 F H+ D L + +P+ SP+ R L+ LL+R+ + RL A Sbjct: 201 F--------HDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERL-----TAP 247 Query: 446 EVKESPFFRSL 456 E+ P+F S+ Sbjct: 248 EILLHPWFESV 258 >5XD6-A nrPDB Length = 305 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 64/224 (28%), Positives = 101/224 (45%), Gaps = 35/224 (15%) Query: 189 NDFSVHRIIGRGGFGEV-YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 +++ +IG G +G V YG K +GK A+K LD KQ + L + M+S + Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILK--SGKAAAIKKLDSS----KQPDQEFLAQVSMVSRLR 75 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL--------SQHG-VFSEADMRFYA 298 + + + Y P ++ + G LH L +Q G V S A Sbjct: 76 QENV--VALLGYCVDGPLRV-LAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIA 132 Query: 299 AEIILGLEHMH---NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP------HA 349 GLE++H N V++RD+K +N+LL + +I+D D S + P H+ Sbjct: 133 VGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADF----DLSNQAPDMAARLHS 188 Query: 350 S--VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 + +GT GY APE G + +D +S G +L +LL G P Sbjct: 189 TRVLGTFGYHAPEYAMTGT-LSTKSDVYSFGVVLLELLTGRKPV 231 >5CEK-A nrPDB Length = 263 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 53/191 (27%), Positives = 84/191 (43%), Gaps = 25/191 (13%) Query: 277 GDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL--DEHGHVRIS 334 GD+H ++ E + +I+ + H H +V DLK + +E +R+ Sbjct: 85 GDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLE 144 Query: 335 DLGLACDFSKKKPHASVGTHG---YMAPEVLQKGVAYDS-SADWFSLGCMLFKLLRGHSP 390 L K + A HG Y++PE+L Y +AD +SLG ML+ LL G P Sbjct: 145 SLE-DTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYP 203 Query: 391 FRQHKTKDKHEIDRMTLTMAVE-----LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQ 445 F H+ D L + +P+ SP+ R L+ LL+R+ + RL A Sbjct: 204 F--------HDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERL-----TAP 250 Query: 446 EVKESPFFRSL 456 E+ P+F S+ Sbjct: 251 EILLHPWFESV 261 >3IO7-A nrPDB Length = 313 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 67/268 (25%), Positives = 117/268 (43%), Gaps = 37/268 (13%) Query: 197 IGRGGFGEVYGCR----KADTGKMYAMKCLDKKRIKMKQGETLALNER---IMLSLVSTG 249 +G+G FG V CR + +TG++ A+K +++ E L ER I+ SL Sbjct: 36 LGKGNFGSVEMCRYDPLQDNTGEVVAVK-----KLQHSTEEHLRDFEREIEILKSLQHDN 90 Query: 250 DCPFI-VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIILGLEH 307 + VC S L I++ + G L +L +H + Y ++I G+E+ Sbjct: 91 IVKYKGVCYSAGRRN---LKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEY 147 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPEVL 362 + + ++RDL NIL++ V+I D GL + K + V G + APE L Sbjct: 148 LGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESL 207 Query: 363 QKGVAYDSSADWFSLGCMLFKLL----RGHSP---FRQHKTKDK-------HEIDRMTLT 408 + + ++D +S G +L++L + SP F + DK H I+ + Sbjct: 208 TES-KFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNN 266 Query: 409 MAVELPDSFSPELRSLLEGLLQRDVNRR 436 + PD E+ ++ +VN+R Sbjct: 267 GRLPRPDGCPDEIYMIMTECWNNNVNQR 294 >2I6L-A nrPDB Length = 320 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 39/131 (29%), Positives = 67/131 (51%), Gaps = 11/131 (8%) Query: 285 QHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHV-RISDLGLACDFS 343 + G E R + +++ GL+++H+ V++RDLKPAN+ ++ V +I D GLA Sbjct: 113 EQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMD 172 Query: 344 ---KKKPHASVG--THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 K H S G T Y +P +L Y + D ++ GC+ ++L G + F Sbjct: 173 PHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLF-----AG 227 Query: 399 KHEIDRMTLTM 409 HE+++M L + Sbjct: 228 AHELEQMQLIL 238 >4LFI-A nrPDB Length = 374 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 31/104 (29%), Positives = 60/104 (57%), Gaps = 2/104 (1%) Query: 290 SEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFS-KKKP 347 ++ ++RFY E++ L++ H+ +++RD+KP N+++D ++ +R+ D GLA + + Sbjct: 170 TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY 229 Query: 348 HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 + V + + PE+L YD S D +S G ML ++ PF Sbjct: 230 NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 273 >3DKO-A nrPDB Length = 318 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 96/214 (44%), Gaps = 12/214 (5%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 + R+IG G FGEV R GK + K +K+ E + S++ D P Sbjct: 47 IERVIGAGEFGEVCSGRLKLPGKRDVAVAI--KTLKVGYTEKQRRDFLCEASIMGQFDHP 104 Query: 253 FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLEHMHNR 311 +V + + +++ M G L L +H G F+ + I G+ ++ + Sbjct: 105 NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADM 164 Query: 312 FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG------YMAPEVLQKG 365 V+RDL NIL++ + ++SD GL+ + P A T G + APE +Q Sbjct: 165 GYVHRDLAARNILVNSNLVCKVSDFGLS-RVIEDDPEAVYTTTGGKIPVRWTAPEAIQYR 223 Query: 366 VAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 + S++D +S G ++++++ G P+ +D Sbjct: 224 -KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQD 256 >2JD5-A nrPDB Length = 373 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 41/128 (32%), Positives = 72/128 (56%), Gaps = 14/128 (10%) Query: 298 AAEIILGLEHMHNRF-VVYRDLKPANILLD------EHGHVRISDLGLACDFSKKKPHAS 350 + +++LGL++MH R +++ D+KP N+L++ ++I+DLG AC + + + S Sbjct: 137 SKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTN-S 195 Query: 351 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGH---SPFRQHK-TKDKHEIDRMT 406 + T Y +PEVL G + AD +S C++F+L+ G P H TKD I ++ Sbjct: 196 IQTREYRSPEVLL-GAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQI- 253 Query: 407 LTMAVELP 414 + + ELP Sbjct: 254 IELLGELP 261 >6NT9-A nrPDB Length = 742 Score = 57.0 bits (136), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 49/219 (22%), Positives = 97/219 (44%), Gaps = 32/219 (14%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKR------IKMKQGETLA-LNERIMLSLVST 248 I+G+G V+ R TG ++A+K + ++M++ E L LN + ++ L + Sbjct: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL---SQHGVFSEADMRFYAAEIILGL 305 + T I++ G L+ L S E++ +++ G+ Sbjct: 74 EEET----------TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 Query: 306 EHMHNRFVVYRDLKPANIL--LDEHGH--VRISDLGLACDFSKKKPHASV-GTHGYMAPE 360 H+ +V+R++KP NI+ + E G +++D G A + + S+ GT Y+ P+ Sbjct: 124 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 Query: 361 VLQKGV-------AYDSSADWFSLGCMLFKLLRGHSPFR 392 + ++ V Y ++ D +S+G + G PFR Sbjct: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 >4XLV-A nrPDB Length = 328 Score = 57.0 bits (136), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 95/209 (45%), Gaps = 25/209 (11%) Query: 195 RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQ-GETLALNERIML----SLVSTG 249 R +G+G FG VY D K A + R+ +K E+ +L ERI S++ Sbjct: 45 RELGQGSFGMVYEGNARDIIKGEA-----ETRVAVKTVNESASLRERIEFLNEASVMKGF 99 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEAD----------MRFYAA 299 C +V + +++LM GDL +L +E + M AA Sbjct: 100 TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAA 159 Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH----G 355 EI G+ +++ + V+RDL N ++ V+I D G+ D + + G Sbjct: 160 EIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR 219 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKL 384 +MAPE L+ GV + +S+D +S G +L+++ Sbjct: 220 WMAPESLKDGV-FTTSSDMWSFGVVLWEI 247 >2GCD-A nrPDB Length = 309 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 89/206 (43%), Gaps = 13/206 (6%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD-KKRIKMKQGETLALNERIMLSLVSTG 249 FS R IG G FG VY R ++ A+K + + ++ + + R + L Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIILGLEHM 308 + C Y L L + DL L H E ++ + GL ++ Sbjct: 77 TIQYRGC--YLREHTAWLVMEYCLGSASDL---LEVHKKPLQEVEIAAVTHGALQGLAYL 131 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEV---LQKG 365 H+ +++RD+K NILL E G V++ D G A + ++ VGT +MAPEV + +G Sbjct: 132 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA--NSFVGTPYWMAPEVILAMDEG 189 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPF 391 YD D +SLG +L P Sbjct: 190 -QYDGKVDVWSLGITCIELAERKPPL 214 >3VHK-A nrPDB Length = 368 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 41/130 (31%), Positives = 65/130 (50%), Gaps = 7/130 (5%) Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH-- 354 Y+ ++ G+E + +R ++RDL NILL E V+I D GLA D K + G Sbjct: 205 YSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARL 264 Query: 355 --GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAV 411 +MAPE + V Y +D +S G +L+++ G SP+ K D+ R+ + Sbjct: 265 PLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPGVKI-DEEFCRRLKEGTRM 322 Query: 412 ELPDSFSPEL 421 PD +PE+ Sbjct: 323 RAPDYTTPEM 332 >6DBM-A nrPDB Length = 318 Score = 56.6 bits (135), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 90/200 (45%), Gaps = 14/200 (7%) Query: 195 RIIGRGGFGEV----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 R +G G FG+V Y TG+M A+K L K + I+ +L Sbjct: 37 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KADAGPQHRSGWKQEIDILRTLYHEHI 95 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 + C A L +++ + G L +L +H + A + +A +I G+ ++H+ Sbjct: 96 IKYKGCCEDA--GAASLQLVMEYVPLGSLRDYLPRHSI-GLAQLLLFAQQICEGMAYLHS 152 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPEVLQKG 365 + ++RDL N+LLD V+I D GLA + + V G + APE L++ Sbjct: 153 QHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEY 212 Query: 366 VAYDSSADWFSLGCMLFKLL 385 Y +S W S G L++LL Sbjct: 213 KFYYASDVW-SFGVTLYELL 231 >1U5R-A nrPDB Length = 348 Score = 56.2 bits (134), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 89/206 (43%), Gaps = 13/206 (6%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD-KKRIKMKQGETLALNERIMLSLVSTG 249 FS R IG G FG VY R ++ A+K + + ++ + + R + L Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIILGLEHM 308 + C Y L L + DL L H E ++ + GL ++ Sbjct: 116 TIQYRGC--YLREHTAWLVMEYCLGSASDL---LEVHKKPLQEVEIAAVTHGALQGLAYL 170 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEV---LQKG 365 H+ +++RD+K NILL E G V++ D G A + ++ VGT +MAPEV + +G Sbjct: 171 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA--NSFVGTPYWMAPEVILAMDEG 228 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPF 391 YD D +SLG +L P Sbjct: 229 -QYDGKVDVWSLGITCIELAERKPPL 253 >4EUT-A nrPDB Length = 396 Score = 56.2 bits (134), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 49/219 (22%), Positives = 97/219 (44%), Gaps = 32/219 (14%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKR------IKMKQGETLA-LNERIMLSLVST 248 I+G+G V+ R TG ++A+K + ++M++ E L LN + ++ L + Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 75 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL---SQHGVFSEADMRFYAAEIILGL 305 + T I++ G L+ L S E++ +++ G+ Sbjct: 76 EEET----------TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 125 Query: 306 EHMHNRFVVYRDLKPANIL--LDEHGH--VRISDLGLACDFSKKKPHASV-GTHGYMAPE 360 H+ +V+R++KP NI+ + E G +++D G A + + S+ GT Y+ P+ Sbjct: 126 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 185 Query: 361 VLQKGV-------AYDSSADWFSLGCMLFKLLRGHSPFR 392 + ++ V Y ++ D +S+G + G PFR Sbjct: 186 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 224 >4XUF-A nrPDB Length = 297 Score = 55.5 bits (132), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 59/230 (25%), Positives = 100/230 (43%), Gaps = 38/230 (16%) Query: 195 RIIGRGGFGEV-----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 +++G G FG+V YG K A+K L K++ + E L ++M L S Sbjct: 15 KVLGSGAFGKVMNATAYGISKTGVSIQVAVKML-KEKADSSEREALMSELKMMTQLGSHE 73 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDL-HYHLSQHGVFSEADMRF------------ 296 + IV + A + I + GDL +Y S+ FSE ++ + Sbjct: 74 N---IVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDL 130 Query: 297 ----------YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 346 +A ++ G+E + + V+RDL N+L+ V+I D GLA D Sbjct: 131 NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS 190 Query: 347 PHASVGTH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 + G +MAPE L +G+ Y +D +S G +L+++ G +P+ Sbjct: 191 NYVVRGNARLPVKWMAPESLFEGI-YTIKSDVWSYGILLWEIFSLGVNPY 239 >6O8B-A nrPDB Length = 665 Score = 55.5 bits (132), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 48/219 (21%), Positives = 96/219 (43%), Gaps = 32/219 (14%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKR------IKMKQGETLA-LNERIMLSLVST 248 I+G+G V+ R TG ++A+K + ++M++ E L LN + ++ L + Sbjct: 22 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 81 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL---SQHGVFSEADMRFYAAEIILGL 305 + T I++ G L+ L S E++ +++ G+ Sbjct: 82 EEET----------TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 131 Query: 306 EHMHNRFVVYRDLKPANIL--LDEHGH--VRISDLGLACDFSKKKPHASV-GTHGYMAPE 360 H+ +V+R++KP NI+ + E G +++D G A + + + GT Y+ P+ Sbjct: 132 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPD 191 Query: 361 VLQKGV-------AYDSSADWFSLGCMLFKLLRGHSPFR 392 + ++ V Y ++ D +S+G + G PFR Sbjct: 192 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 230 >5X02-A nrPDB Length = 347 Score = 55.5 bits (132), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 59/230 (25%), Positives = 100/230 (43%), Gaps = 38/230 (16%) Query: 195 RIIGRGGFGEV-----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 +++G G FG+V YG K A+K L K++ + E L ++M L S Sbjct: 54 KVLGSGAFGKVMNATAYGISKTGVSIQVAVKML-KEKADSSEREALMSELKMMTQLGSHE 112 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDL-HYHLSQHGVFSEADMRF------------ 296 + IV + A + I + GDL +Y S+ FSE ++ + Sbjct: 113 N---IVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDL 169 Query: 297 ----------YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 346 +A ++ G+E + + V+RDL N+L+ V+I D GLA D Sbjct: 170 NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS 229 Query: 347 PHASVGTH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 + G +MAPE L +G+ Y +D +S G +L+++ G +P+ Sbjct: 230 NYVVRGNARLPVKWMAPESLFEGI-YTIKSDVWSYGILLWEIFSLGVNPY 278 >4EUU-A nrPDB Length = 319 Score = 55.1 bits (131), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 49/219 (22%), Positives = 97/219 (44%), Gaps = 32/219 (14%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKR------IKMKQGETLA-LNERIMLSLVST 248 I+G+G V+ R TG ++A+K + ++M++ E L LN + ++ L + Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 75 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL---SQHGVFSEADMRFYAAEIILGL 305 + T I++ G L+ L S E++ +++ G+ Sbjct: 76 EEET----------TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 125 Query: 306 EHMHNRFVVYRDLKPANIL--LDEHGH--VRISDLGLACDFSKKKPHASV-GTHGYMAPE 360 H+ +V+R++KP NI+ + E G +++D G A + + S+ GT Y+ P+ Sbjct: 126 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 185 Query: 361 VLQKGV-------AYDSSADWFSLGCMLFKLLRGHSPFR 392 + ++ V Y ++ D +S+G + G PFR Sbjct: 186 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 224 >5C26-A nrPDB Length = 299 Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 46/207 (22%), Positives = 93/207 (44%), Gaps = 14/207 (6%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML--SLVSTGDCPFI 254 +G G FG V K +M + +I + AL + ++ +++ D P+I Sbjct: 35 LGSGNFGTV----KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 90 Query: 255 VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVV 314 V M + ++++ G L+ +L Q+ + ++ ++ +G++++ V Sbjct: 91 VRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 149 Query: 315 YRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPEVLQKGVAYD 369 +RDL N+LL + +ISD GL+ + + THG + APE + + Sbjct: 150 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY-YKFS 208 Query: 370 SSADWFSLGCMLFKLLR-GHSPFRQHK 395 S +D +S G ++++ G P+R K Sbjct: 209 SKSDVWSFGVLMWEAFSYGQKPYRGMK 235 >4OLI-A nrPDB Length = 645 Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 91/205 (44%), Gaps = 24/205 (11%) Query: 195 RIIGRGGFGEV----YGCRKADTGKMYAMK-----CLDKKRIKMKQGETLALNERIMLSL 245 R +G G FG+V Y TG+M A+K C + R KQ E L + Sbjct: 359 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQ-EIDILRTLYHEHI 417 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 + C C L +++ + G L +L +H + A + +A +I G+ Sbjct: 418 IKYKGC----CEDQG---EKSLQLVMEYVPLGSLRDYLPRHSI-GLAQLLLFAQQICEGM 469 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPE 360 ++H++ ++R+L N+LLD V+I D GLA + + V G + APE Sbjct: 470 AYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPE 529 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLL 385 L++ Y +S W S G L++LL Sbjct: 530 CLKEYKFYYASDVW-SFGVTLYELL 553 >5AR8-A nrPDB Length = 326 Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 61/220 (27%), Positives = 92/220 (41%), Gaps = 35/220 (15%) Query: 195 RIIGRGGFGEVYGCRKADTGKMYAMK-------CLDKKRIKMKQGETLALNERIMLSLVS 247 R + RG G V R AD A+K LD +R + + + R L Sbjct: 38 RYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPI 97 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEA--DMRF-YAAEIILG 304 G C + P+ L + + M G L+ L + + + +RF EI LG Sbjct: 98 LGIC----------NEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALG 147 Query: 305 LEHMHNRF--VVYRDLKPANILLDEHGHVRISDLGLA---------CDFSKKKPHASVGT 353 + ++HN +++ DLK NILLD HV+I+D GL+ SK P GT Sbjct: 148 VNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEG--GT 205 Query: 354 HGYMAPEVLQKGVAYDSSA--DWFSLGCMLFKLLRGHSPF 391 YM PE + G +S D +S + +++L PF Sbjct: 206 IIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPF 245 >4E20-A nrPDB Length = 290 Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 69/268 (25%), Positives = 113/268 (42%), Gaps = 35/268 (13%) Query: 195 RIIGRGGFGEV----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 R +G G FG+V Y TG+M A+K L K G L + + ++ T Sbjct: 14 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-----KEGCGPQLRSGWQREIEILRTLY 68 Query: 251 CPFIVCMSYAFHTPDK----LSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 IV Y D+ + +++ + G L +L +H V A + +A +I G+ Sbjct: 69 HEHIV--KYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCV-GLAQLLLFAQQICEGMA 125 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPEV 361 ++H + ++R L N+LLD V+I D GLA + + V G + APE Sbjct: 126 YLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPEC 185 Query: 362 LQKGVAYDSSADWFSLGCMLFKLL----RGHSPFRQHKTKDKHEIDRMTLTMAVEL---- 413 L++ Y +S W S G L++LL SP + H +MT+ EL Sbjct: 186 LKECKFYYASDVW-SFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTELLERG 244 Query: 414 -----PDSFSPELRSLLEGLLQRDVNRR 436 PD E+ L++ + + + R Sbjct: 245 ERLPRPDRCPCEIYHLMKNCWETEASFR 272 >3ZZW-A nrPDB Length = 289 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 47/175 (26%), Positives = 80/175 (45%), Gaps = 24/175 (13%) Query: 252 PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEA----------------DMR 295 P +VC+ LS I + GDLH L S+ D Sbjct: 72 PNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFV 131 Query: 296 FYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGL-----ACDFSKKKPHAS 350 A+I G+E++ + VV++DL N+L+ + +V+ISDLGL A D+ K ++ Sbjct: 132 HLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSL 191 Query: 351 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDR 404 + +MAPE + G + +D +S G +L+++ G P+ + +D E+ R Sbjct: 192 LPIR-WMAPEAIMYG-KFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIR 244 >5CLR-A nrPDB Length = 451 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 62/246 (25%), Positives = 105/246 (42%), Gaps = 45/246 (18%) Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEV--L 362 ++ H +++RDLKP NI+LD + D G + + KP AS GT Y+APE+ Sbjct: 189 VKQFHELGLIHRDLKPGNIMLDADMQCHLVDFGSSSSDKEPKP-ASWGTASYLAPELNAQ 247 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHK-------TKDKHEIDRMTLTMAVELPD 415 + +A+ +D F+L L +L +PFRQ K K+KH + L A Sbjct: 248 EDFIAFSQVSDLFALAYSLDELF---NPFRQVKFAKVDIGIKNKH----LVLLHA----- 295 Query: 416 SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS----LDWQMVFLQKYPPPLI 471 E+ + + GL+ + + R R Q + F+S + ++ L ++ Sbjct: 296 ----EIEACITGLMSNETSVRTLYFSRILQLQRVPESFKSRPEAFTYLIMLLTQWKSCYE 351 Query: 472 PPR---------GEVNAA------DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISER 516 P E+ A DA I + E+ +K LL+S + L +++ Sbjct: 352 APEMNKELDEIIAEIKVAYENHEQDAVKIITLLEQLSKADGLLNSHKALLSVLIKSLANV 411 Query: 517 WQQEVA 522 QQE+ Sbjct: 412 QQQELG 417 >2R2P-A nrPDB Length = 295 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 100/219 (45%), Gaps = 18/219 (8%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKM---YAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 ++ R+IG G FGEV R GK A+K L + ++ + L S++ Sbjct: 24 ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLG-----EASIMG 78 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLE 306 D P I+ + + + + M G L L ++ G F+ + I G++ Sbjct: 79 QFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMK 138 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG------YMAPE 360 ++ + V+RDL NIL++ + ++SD GL+ + P A+ T G + APE Sbjct: 139 YLSDMGYVHRDLAARNILINSNLVCKVSDFGLS-RVLEDDPEAAYTTRGGKIPIRWTAPE 197 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 + + S++D +S G ++++++ G P+ + +D Sbjct: 198 AIAFR-KFTSASDVWSYGIVMWEVVSYGERPYWEMTNQD 235 >2QLU-A nrPDB Length = 314 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 30/85 (35%), Positives = 45/85 (52%), Gaps = 8/85 (9%) Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP----HASVGTHGYMAPEVLQK 364 H + +RD K N+LL ++D GLA F KP H VGT YMAPEVL+ Sbjct: 140 HKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEG 199 Query: 365 GVAYDSSA----DWFSLGCMLFKLL 385 + + A D +++G +L++L+ Sbjct: 200 AINFQRDAFLRIDMYAMGLVLWELV 224 >3RAW-A nrPDB Length = 381 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 51/223 (22%), Positives = 92/223 (41%), Gaps = 24/223 (10%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G FG+V C GK + + K ++ L +N + + V Sbjct: 59 LGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVL 118 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEIILGLEHMHNRFVV 314 MS F+ + +L+ + L ++ + +R A ++ L +H + Sbjct: 119 MSDWFNFHGHMCIAFELLGKNTFEF-LKENNFQPYPLPHVRHMAYQLCHALRFLHENQLT 177 Query: 315 YRDLKPANILL---------DEH----------GHVRISDLGLACDFSKKKPHASVGTHG 355 + DLKP NIL +EH +R++D G A F + V T Sbjct: 178 HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSAT-FDHEHHTTIVATRH 236 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 Y PEV+ + + + D +S+GC+LF+ RG + F+ H+ ++ Sbjct: 237 YRPPEVILE-LGWAQPCDVWSIGCILFEYYRGFTLFQTHENRE 278 >3QD2-B nrPDB Length = 332 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 33/104 (31%), Positives = 51/104 (49%), Gaps = 15/104 (14%) Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS--------- 350 +I +E +H++ +++RDLKP+NI V++ D GL + + + Sbjct: 172 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA 231 Query: 351 -----VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHS 389 VGT YM+PE + G Y D FSLG +LF+LL S Sbjct: 232 THTGQVGTKLYMSPEQIH-GNNYSHKVDIFSLGLILFELLYSFS 274 >4AT3-A nrPDB Length = 299 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 48/191 (25%), Positives = 88/191 (46%), Gaps = 23/191 (12%) Query: 265 DKLSFILDLMNGGDLHYHLSQHGV-------------FSEADMRFYAAEIILGLEHMHNR 311 D L + + M GDL+ L HG +++ M A +I G+ ++ ++ Sbjct: 88 DPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ 147 Query: 312 FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPEVLQKGV 366 V+RDL N L+ E+ V+I D G++ D + VG H +M PE + Sbjct: 148 HFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTD-YYRVGGHTMLPIRWMPPESIMYR- 205 Query: 367 AYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 + + +D +SLG +L+++ G P+ Q + I+ +T ++ P + E+ L+ Sbjct: 206 KFTTESDVWSLGVVLWEIFTYGKQPWYQ--LSNNEVIECITQGRVLQRPRTCPQEVYELM 263 Query: 426 EGLLQRDVNRR 436 G QR+ + R Sbjct: 264 LGCWQREPHMR 274 >2BUJ-A nrPDB Length = 317 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 47/154 (30%), Positives = 68/154 (44%), Gaps = 17/154 (11%) Query: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLG---LAC----- 340 +E + + I GLE +H + +RDLKP NILL + G + DLG AC Sbjct: 131 LTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEG 190 Query: 341 ---DFSKKKPHASVGTHGYMAPEV--LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHK 395 + + A T Y APE+ +Q D D +SLGC+L+ ++ G P+ Sbjct: 191 SRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVF 250 Query: 396 TKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLL 429 K D + L + +L SP S L LL Sbjct: 251 QKG----DSVALAVQNQLSIPQSPRHSSALWQLL 280 >4EBW-A nrPDB Length = 304 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 61/247 (24%), Positives = 101/247 (40%), Gaps = 11/247 (4%) Query: 195 RIIGRGGFGEVY-GCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPF 253 R IG G FG+V+ G + A+ K L E + + D P Sbjct: 44 RCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQF---DHPH 100 Query: 254 IVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADMRFYAAEIILGLEHMHNRF 312 IV + T + + I++L G+L L + A + YA ++ L ++ ++ Sbjct: 101 IVKL-IGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKR 159 Query: 313 VVYRDLKPANILLDEHGHVRISDLGLAC---DFSKKKPHASVGTHGYMAPEVLQKGVAYD 369 V+RD+ N+L+ + V++ D GL+ D + K +MAPE + Sbjct: 160 FVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTS 219 Query: 370 SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLL 429 +S W CM L+ G PF+ K D I R+ + +P + P L SL+ Sbjct: 220 ASDVWMFGVCMWEILMHGVKPFQGVKNNDV--IGRIENGERLPMPPNCPPTLYSLMTKCW 277 Query: 430 QRDVNRR 436 D +RR Sbjct: 278 AYDPSRR 284 >2Y4I-B nrPDB Length = 319 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 52/216 (24%), Positives = 100/216 (46%), Gaps = 24/216 (11%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 + +IG+G FG+VY R A++ +D +R Q L +R +++ T Sbjct: 37 IGELIGKGRFGQVYHGRWHGE---VAIRLIDIERDNEDQ---LKAFKREVMAYRQTRHEN 90 Query: 253 FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEAD-MRFYAAEIILGLEHMHNR 311 ++ M A +P L+ I L G L+ + + + + R A EI+ G+ ++H + Sbjct: 91 VVLFMG-ACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK 149 Query: 312 FVVYRDLKPANILLDEHGHVRISDLG-------LACDFSKKKPHASVGTHGYMAPEVLQK 364 ++++DLK N+ D +G V I+D G L + K G ++APE++++ Sbjct: 150 GILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQ 208 Query: 365 --------GVAYDSSADWFSLGCMLFKLLRGHSPFR 392 + + +D F+LG + ++L PF+ Sbjct: 209 LSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFK 244 >1U59-A nrPDB Length = 287 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/242 (23%), Positives = 106/242 (43%), Gaps = 26/242 (10%) Query: 197 IGRGGFGEV----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM--LSLVSTGD 250 +G G FG V Y RK K +D +KQG A E +M ++ D Sbjct: 18 LGCGNFGSVRQGVYRMRK---------KQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 68 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLH-YHLSQHGVFSEADMRFYAAEIILGLEHMH 309 P+IV + + L ++++ GG LH + + + +++ ++ +G++++ Sbjct: 69 NPYIVRL-IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 127 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPEVLQK 364 + V+RDL N+LL + +ISD GL+ + + + G + APE + Sbjct: 128 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN- 186 Query: 365 GVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 + S +D +S G +++ L G P+++ K + M E P PEL + Sbjct: 187 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM--ECPPECPPELYA 244 Query: 424 LL 425 L+ Sbjct: 245 LM 246 >3I81-A nrPDB Length = 315 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 97/214 (45%), Gaps = 27/214 (12%) Query: 191 FSVHRIIGRGGFGEVY-GCRKADTGKMYAMKCLDKKRIKMKQ-GETLALNERIML----S 244 ++ R +G+G FG VY G K +K + R+ +K E ++ ERI S Sbjct: 20 ITMSRELGQGSFGMVYEGVAKG------VVKDEPETRVAIKTVNEAASMRERIEFLNEAS 73 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL-------SQHGVF---SEADM 294 ++ +C +V + I++LM GDL +L + V S + M Sbjct: 74 VMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKM 133 Query: 295 RFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH 354 A EI G+ +++ V+RDL N ++ E V+I D G+ D + + G Sbjct: 134 IQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKG 193 Query: 355 ----GYMAPEVLQKGVAYDSSADWFSLGCMLFKL 384 +M+PE L+ GV + + +D +S G +L+++ Sbjct: 194 LLPVRWMSPESLKDGV-FTTYSDVWSFGVVLWEI 226 >5HLW-A nrPDB Length = 299 Score = 53.9 bits (128), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 98/212 (46%), Gaps = 12/212 (5%) Query: 196 IIGRGGFGEVY-GCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 254 +IGRG FG VY G + GK RI + L E I++ S + + Sbjct: 27 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV--L 84 Query: 255 VCMSYAFHTPDKLSFILDLMNGGDL-HYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFV 313 + + +L M GDL ++ ++ + D+ + ++ G++++ ++ Sbjct: 85 SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF 144 Query: 314 VYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG------YMAPEVLQKGVA 367 V+RDL N +LDE V+++D GLA D K+ ++ G +MA E LQ Sbjct: 145 VHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQ-K 203 Query: 368 YDSSADWFSLGCMLFKLL-RGHSPFRQHKTKD 398 + + +D +S G +L++L+ RG P+ T D Sbjct: 204 FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFD 235 >3ZBF-A nrPDB Length = 322 Score = 53.9 bits (128), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 105/236 (44%), Gaps = 39/236 (16%) Query: 191 FSVHRIIGRGGFGEVYGCRKAD-----TGKM-YAMKCLDKKRIKMKQGETLALNERIMLS 244 ++ ++G G FGEVY D +G++ A+K L K ++ E L Sbjct: 35 LTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLK-----EAH 89 Query: 245 LVSTGDCPFI-----VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFS-------EA 292 L+S + P I VC+ + P + IL+LM GGDL +L + + + Sbjct: 90 LMSKFNHPNILKQLGVCL---LNEPQYI--ILELMEGGDLLTYLRKARMATFYGPLLTLV 144 Query: 293 DMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGH-----VRISDLGLACDFSKKKP 347 D+ +I G ++ ++RDL N L+ + V+I D GLA D K Sbjct: 145 DLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDY 204 Query: 348 HASVGTH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 + G +MAPE L G+ + + +D +S G +++++L GH P+ H D Sbjct: 205 YRKRGEGLLPVRWMAPESLMDGI-FTTQSDVWSFGILIWEILTLGHQPYPAHSNLD 259 >4FL3-A nrPDB Length = 635 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 49/221 (22%), Positives = 99/221 (44%), Gaps = 18/221 (8%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML-- 243 LT+ D + +G G FG V K +M + +I + AL + ++ Sbjct: 370 LTLED----KELGSGNFGTV----KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEA 421 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 +++ D P+IV M + ++++ G L+ +L Q+ + ++ ++ + Sbjct: 422 NVMQQLDNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMA 358 G++++ V+RDL N+LL + +ISD GL+ + + THG + A Sbjct: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 PE + + S +D +S G ++++ G P+R K + Sbjct: 541 PECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE 580 >5GNK-A nrPDB Length = 297 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 102/215 (47%), Gaps = 15/215 (6%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM--L 243 L +F +++G G FG VY G+ + K+ +++ + N+ I+ Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKE---LREATSPKANKEILDEA 72 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH--GVFSEADMRFYAAEI 301 ++++ D P VC + I+ LM G L ++ +H + S+ + + +I Sbjct: 73 YVMASVDNPH-VCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLN-WCVQI 130 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA--CDFSKKKPHASVGTH--GYM 357 G+ ++ +R +V+RDL N+L+ HV+I+D GLA +K+ HA G +M Sbjct: 131 AKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM 190 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 A E + + Y +D +S G +++L+ G P+ Sbjct: 191 ALESILHRI-YTHQSDVWSYGVTVWELMTFGSKPY 224 >4P5Q-A nrPDB Length = 361 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 54/233 (23%), Positives = 101/233 (43%), Gaps = 26/233 (11%) Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIK-----MKQGETL 235 E L + S+ +++G G FGEV R +K KK I +K G T Sbjct: 25 EFAKELDATNISIDKVVGAGEFGEVCSGR---------LKLPSKKEISVAIKTLKVGYTE 75 Query: 236 ALNERIM--LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEA 292 + S++ D P I+ + + + + M G L L +H F+ Sbjct: 76 KQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVI 135 Query: 293 DMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG 352 + I G++++ + V+RDL NIL++ + ++SD GL+ + P A+ Sbjct: 136 QLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLS-RVLEDDPEAAYT 194 Query: 353 THG------YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 T G + +PE + + S++D +S G +L++++ G P+ + +D Sbjct: 195 TRGGKIPIRWTSPEAIAYR-KFTSASDVWSYGIVLWEVMSYGERPYWEMSNQD 246 >2J0K-A nrPDB Length = 656 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 64/248 (25%), Positives = 102/248 (41%), Gaps = 13/248 (5%) Query: 195 RIIGRGGFGEVY-GCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPF 253 R IG G FG+V+ G + A+ K L E + + D P Sbjct: 396 RCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQF---DHPH 452 Query: 254 IVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSE--ADMRFYAAEIILGLEHMHNR 311 IV + T + + I++L G+L L Q FS A + YA ++ L ++ ++ Sbjct: 453 IVKL-IGVITENPVWIIMELCTLGELRSFL-QVRKFSLDLASLILYAYQLSTALAYLESK 510 Query: 312 FVVYRDLKPANILLDEHGHVRISDLGLAC---DFSKKKPHASVGTHGYMAPEVLQKGVAY 368 V+RD+ N+L+ V++ D GL+ D + K +MAPE + Sbjct: 511 RFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFT 570 Query: 369 DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGL 428 +S W CM L+ G PF+ K D I R+ + +P + P L SL+ Sbjct: 571 SASDVWMFGVCMWEILMHGVKPFQGVKNNDV--IGRIENGERLPMPPNCPPTLYSLMTKC 628 Query: 429 LQRDVNRR 436 D +RR Sbjct: 629 WAYDPSRR 636 >5OAT-A nrPDB Length = 411 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 45/153 (29%), Positives = 71/153 (46%), Gaps = 24/153 (15%) Query: 304 GLEHMHNRFVVYRDLKPANILLD----EHGHVRISDLGLACDFSKKK-----PHASV--- 351 G+ HM + +RDLK N+LLD E + ISD G C + K P+ S Sbjct: 165 GVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFG--CCLADKTNGLSLPYTSYEMD 222 Query: 352 --GTHGYMAPEVL-QKGVAYD----SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDR 404 G MAPE++ QK + S AD +++G + +++ H+PF Sbjct: 223 KGGNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKE 282 Query: 405 MTLTMAVELPDSFSPELRSLLEGLLQRDVNRRL 437 L +LPD +++L+ LL+R+ N+RL Sbjct: 283 GDLP---KLPDEVPTVIQALVANLLKRNPNKRL 312 >3LZB-A nrPDB Length = 327 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 101/215 (46%), Gaps = 15/215 (6%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM--L 243 L +F +++G G FG VY G+ + K+ +++ + N+ I+ Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKE---LREATSPKANKEILDEA 68 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH--GVFSEADMRFYAAEI 301 ++++ D P VC + I LM G L ++ +H + S+ + + +I Sbjct: 69 YVMASVDNPH-VCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLN-WCVQI 126 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA--CDFSKKKPHASVGTH--GYM 357 G+ ++ +R +V+RDL N+L+ HV+I+D GLA +K+ HA G +M Sbjct: 127 AKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM 186 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 A E + + Y +D +S G +++L+ G P+ Sbjct: 187 ALESILHRI-YTHQSDVWSYGVTVWELMTFGSKPY 220 >5H2U-A nrPDB Length = 267 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 55/216 (25%), Positives = 101/216 (46%), Gaps = 31/216 (14%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI---KMKQGETLALNER------ 240 +F++ R +G G FGEV+ D ++ A+K + + + +M Q E A+ + Sbjct: 7 EFTLCRKLGSGYFGEVFEGLWKDRVQV-AIKVISRDNLLHQQMLQSEIQAMKKLRHKHIL 65 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL--SQHGVFSEADMRFYA 298 + ++VS GD +I I +LM G L L S V +++ A Sbjct: 66 ALYAVVSVGDPVYI---------------ITELMAKGSLLELLRDSDEKVLPVSELLDIA 110 Query: 299 AEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK--PHASVGTHGY 356 ++ G+ ++ ++ ++RDL NIL+ E+ ++ D GLA + H + + Sbjct: 111 WQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKW 170 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLL-RGHSPF 391 APE L +G Y + +D +S G +L ++ RG P+ Sbjct: 171 TAPEALSRG-HYSTKSDVWSFGILLHEMFSRGQVPY 205 >1K9A-A nrPDB Length = 450 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 52/254 (20%), Positives = 104/254 (40%), Gaps = 16/254 (6%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 L M + + + IG+G FG+V G A+KC+ + +M L Sbjct: 190 LNMKELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKND----ATAQAFLAEASVMTQL 243 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAEIIL 303 + + + L + + M G L +L G V + ++ ++ Sbjct: 244 RHSN---LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 363 +E++ V+RDL N+L+ E ++SD GL + S + + + APE L+ Sbjct: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK-WTAPEALR 359 Query: 364 KGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 + + + +D +S G +L+++ G P+ + KD + R+ ++ PD P + Sbjct: 360 EK-KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV--VPRVEKGYKMDAPDGCPPAVY 416 Query: 423 SLLEGLLQRDVNRR 436 +++ D R Sbjct: 417 DVMKNCWHLDAATR 430 >2RIO-A nrPDB Length = 434 Score = 52.4 bits (124), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 36/129 (27%), Positives = 62/129 (48%), Gaps = 26/129 (20%) Query: 300 EIILGLEHMHNRFVVYRDLKPANILLD-------------EHGHVRISDLGLACDFS--- 343 +I G+ H+H+ +++RDLKP NIL+ E+ + ISD GL Sbjct: 123 QIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQ 182 Query: 344 ---KKKPHASVGTHGYMAPEVLQKGVAYDS------SADWFSLGCMLFKLL-RGHSPFRQ 393 + + GT G+ APE+L++ + S D FS+GC+ + +L +G PF Sbjct: 183 SSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGD 242 Query: 394 HKTKDKHEI 402 +++ + I Sbjct: 243 KYSRESNII 251 >4LRM-A nrPDB Length = 334 Score = 52.0 bits (123), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 96/215 (44%), Gaps = 12/215 (5%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDK--KRIKMKQGETLALNERIML 243 L +F +++G G FG VY G+ + K + + L+E ++ Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 75 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH--GVFSEADMRFYAAEI 301 + V P VC + I LM G L ++ +H + S+ + + +I Sbjct: 76 ASVDNPGNPH-VCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLN-WCVQI 133 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA--CDFSKKKPHASVG--THGYM 357 G+ ++ +R +V+RDL N+L+ HV+I+D GLA +K+ HA G +M Sbjct: 134 AKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM 193 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 A E + + Y +D +S G +++L+ G P+ Sbjct: 194 ALESILHRI-YTHQSDVWSYGVTVWELMTFGSKPY 227 >5TE0-A nrPDB Length = 347 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 57/268 (21%), Positives = 110/268 (41%), Gaps = 36/268 (13%) Query: 192 SVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDC 251 +V ++ GGF V+ R ++ MKC K+ + + I + +G Sbjct: 22 TVDEVLAEGGFAIVFLVRTSN-----GMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHK 76 Query: 252 PFIVCMSYAFHTPD-----KLSFILDLMNGGDLHYHLSQ--HGVFSEADMRFYAAEIILG 304 + + + + ++ ++D GG + ++Q F+E ++ + Sbjct: 77 NIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEA 136 Query: 305 LEHMHN--RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG---------- 352 + +H +++RDLK NILL + GH + D G A + + V Sbjct: 137 VARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT 196 Query: 353 THGYMAPEV--LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA 410 T Y APE+ L G + AD ++LGC+L+KL PF + + Sbjct: 197 TLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVA--------ICDGN 248 Query: 411 VELPDS--FSPELRSLLEGLLQRDVNRR 436 +PD+ +S ++ L+ +L+ D ++R Sbjct: 249 FTIPDNSRYSQDMHCLIRYMLEPDPDKR 276 >4C59-A nrPDB Length = 340 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 62/273 (22%), Positives = 114/273 (41%), Gaps = 38/273 (13%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 V R++ GGF VY + +G+ YA+K L + ++ + A+ + + +G P Sbjct: 31 VRRVLAEGGFAFVYEAQDVGSGREYALKRL----LSNEEEKNRAIIQEVCFMKKLSGH-P 85 Query: 253 FIV--CMSYAFHTPD----KLSFIL--DLMNGGDLHY--HLSQHGVFSEADMRFYAAEII 302 IV C + + + + F+L +L G + + + G S + + Sbjct: 86 NIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTC 145 Query: 303 LGLEHMHNRF--VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG-------- 352 ++HMH + +++RDLK N+LL G +++ D G A S ++ Sbjct: 146 RAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEE 205 Query: 353 ------THGYMAPEV--LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDR 404 T Y PE+ L D ++LGC+L+ L FRQH +D ++ Sbjct: 206 EITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLC-----FRQHPFEDGAKLRI 260 Query: 405 MTLTMAVELPDSFSPELRSLLEGLLQRDVNRRL 437 + ++ D+ SL+ +LQ + RL Sbjct: 261 VNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERL 293 >2OZO-A nrPDB Length = 613 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 56/242 (23%), Positives = 106/242 (43%), Gaps = 26/242 (10%) Query: 197 IGRGGFGEV----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM--LSLVSTGD 250 +G G FG V Y RK K +D +KQG A E +M ++ D Sbjct: 344 LGCGNFGSVRQGVYRMRK---------KQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLH-YHLSQHGVFSEADMRFYAAEIILGLEHMH 309 P+IV + + L ++++ GG LH + + + +++ ++ +G++++ Sbjct: 395 NPYIVRL-IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPEVLQK 364 + V+R+L N+LL + +ISD GL+ + + + G + APE + Sbjct: 454 EKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN- 512 Query: 365 GVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 + S +D +S G +++ L G P+++ K + M E P PEL + Sbjct: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM--ECPPECPPELYA 570 Query: 424 LL 425 L+ Sbjct: 571 LM 572 >4IAN-A nrPDB Length = 358 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 29/99 (29%), Positives = 54/99 (54%), Gaps = 2/99 (2%) Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHV-RISDLGLACDFSKKKPHASVG 352 +R Y+ ++ L L+ + +++ D+KP NIL++E + ++ D G A + + Sbjct: 137 VRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLV 196 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 + Y APE++ G +YD D +S+GC L++L G F Sbjct: 197 SRFYRAPEIII-GKSYDYGIDMWSVGCTLYELYTGKILF 234 >3C1X-A nrPDB Length = 373 Score = 51.2 bits (121), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 97/214 (45%), Gaps = 12/214 (5%) Query: 194 HRIIGRGGFGEVY-GCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 + +IGRG FG VY G + GK RI + L E I++ S + Sbjct: 94 NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV- 152 Query: 253 FIVCMSYAFHTPDKLSFILDLMNGGDL-HYHLSQHGVFSEADMRFYAAEIILGLEHMHNR 311 + + + +L M GDL ++ ++ + D+ + ++ G++ + ++ Sbjct: 153 -LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASK 211 Query: 312 FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK---PHASVGTH---GYMAPEVLQKG 365 V+RDL N +LDE V+++D GLA D K+ H G +MA E LQ Sbjct: 212 KFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQ 271 Query: 366 VAYDSSADWFSLGCMLFKLL-RGHSPFRQHKTKD 398 + + +D +S G +L++L+ RG P+ T D Sbjct: 272 -KFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFD 304 >1BYG-A nrPDB Length = 278 Score = 51.2 bits (121), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/254 (20%), Positives = 104/254 (40%), Gaps = 16/254 (6%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 L M + + + IG+G FG+V G A+KC+ + +M L Sbjct: 18 LNMKELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKND----ATAQAFLAEASVMTQL 71 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAEIIL 303 + + + L + + M G L +L G V + ++ ++ Sbjct: 72 RHSN---LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 128 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 363 +E++ V+RDL N+L+ E ++SD GL + S + + + APE L+ Sbjct: 129 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK-WTAPEALR 187 Query: 364 KGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 + + + +D +S G +L+++ G P+ + KD + R+ ++ PD P + Sbjct: 188 EK-KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV--VPRVEKGYKMDAPDGCPPAVY 244 Query: 423 SLLEGLLQRDVNRR 436 +++ D R Sbjct: 245 EVMKNCWHLDAAMR 258 >1JPA-A nrPDB Length = 312 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 58/256 (22%), Positives = 110/256 (42%), Gaps = 20/256 (7%) Query: 193 VHRIIGRGGFGEVYGCRKADTGK---MYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + ++IG G FGEV GK A+K L + ++ + L+ S++ Sbjct: 37 IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLS-----EASIMGQF 91 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLEHM 308 D P ++ + + I + M G L L Q+ G F+ + I G++++ Sbjct: 92 DHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL 151 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLA--CDFSKKKPHASVGTHG-----YMAPEV 361 + V+RDL NIL++ + ++SD GL+ + P + G + APE Sbjct: 152 ADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEA 211 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 +Q + S++D +S G ++++++ G P+ +D I+ + + P Sbjct: 212 IQYR-KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDV--INAIEQDYRLPPPMDCPSA 268 Query: 421 LRSLLEGLLQRDVNRR 436 L L+ Q+D N R Sbjct: 269 LHQLMLDCWQKDRNHR 284 >3MY0-A nrPDB Length = 305 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 89/209 (42%), Gaps = 25/209 (11%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G+G +GEV+ R G+ A+K + + ET N ++ G FI Sbjct: 16 VGKGRYGEVW--RGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILG---FIAS 70 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF---- 312 + ++ +L I G L+ L + + +R A GL H+H Sbjct: 71 DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRL-AVSAACGLAHLHVEIFGTQ 129 Query: 313 ----VVYRDLKPANILLDEHGHVRISDLGLAC------DFSKKKPHASVGTHGYMAPEVL 362 + +RD K N+L+ + I+DLGLA D+ + VGT YMAPEVL Sbjct: 130 GKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVL 189 Query: 363 QKGVAYDS--SADW---FSLGCMLFKLLR 386 + + D S W ++ G +L+++ R Sbjct: 190 DEQIRTDCFESYKWTDIWAFGLVLWEIAR 218 >2Y6O-A nrPDB Length = 291 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/214 (23%), Positives = 96/214 (44%), Gaps = 12/214 (5%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 + ++IG G FGEV R GK C+ K +K + + S++ D P Sbjct: 18 IEKVIGVGEFGEVCSGRLKVPGKREI--CVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP 75 Query: 253 FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLEHMHNR 311 I+ + + I + M G L L ++ G F+ + I G++++ + Sbjct: 76 NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDM 135 Query: 312 FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG------YMAPEVLQKG 365 V+RDL NIL++ + ++SD G++ + P A+ T G + APE + Sbjct: 136 SYVHRDLAARNILVNSNLVCKVSDFGMS-RVLEDDPEAAYTTRGGKIPIRWTAPEAIAYR 194 Query: 366 VAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 + S++D +S G ++++++ G P+ +D Sbjct: 195 -KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQD 227 >4CSV-A nrPDB Length = 275 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 49/210 (23%), Positives = 98/210 (46%), Gaps = 16/210 (7%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 ++ ++ R +G G FGEVY + + A+K L + + + E +IM L Sbjct: 11 SEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSV---EEFLQEAQIMKKL--- 64 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ---HGVFSEADMRFYAAEIILGL 305 P +V + + I + M+ G L +L H V ++A + AA++ G+ Sbjct: 65 -KHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDM-AAQVASGM 122 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GYMAPEVL 362 ++ ++ ++RDL N L+ E+ V+++D GLA ++ + A G + APE + Sbjct: 123 AYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAI 182 Query: 363 QKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 + +D ++ G +L+++ G P+ Sbjct: 183 SYN-RFSIKSDVWAFGILLWEIFTYGQVPY 211 >3M42-A nrPDB Length = 299 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 59/263 (22%), Positives = 114/263 (43%), Gaps = 42/263 (15%) Query: 188 MNDFSV-HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 ++D+ V +++G G G+V T + +A+K L ++ E L+ R Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---LHWR------ 66 Query: 247 STGDCPFIVCMSYAFHT----PDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAE 300 CP IV + + L +++ ++GG+L + G F+E + Sbjct: 67 -ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 125 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGY-MAP 359 I ++++H+ + +RD+KP N+L ++ K+P+A + + A Sbjct: 126 IGEAIQYLHSINIAHRDVKPENLL-----------------YTSKRPNAILKLTDFGFAK 168 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA-VELPD--- 415 E G YD S D +SLG +++ LL G+ PF + + + M E P+ Sbjct: 169 ET--TGEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 226 Query: 416 -SFSPELRSLLEGLLQRDVNRRL 437 S E++ L+ LL+ + +R+ Sbjct: 227 SEVSEEVKMLIRNLLKTEPTQRM 249 >4PDO-A nrPDB Length = 299 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 98/215 (45%), Gaps = 29/215 (13%) Query: 194 HRIIGRGGFGEVY-GCRKADTGKM---YAMKCL-----DKKRIKMKQGETLALNERIMLS 244 ++IG G FGEVY G K +GK A+K L +K+R+ L E ++ Sbjct: 39 QKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDF-------LGEAGIMG 91 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIIL 303 S + I+ + + I + M G L L + G FS + I Sbjct: 92 QFSHHN---IIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAA 148 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG------YM 357 G++++ N V+RDL NIL++ + ++SD GL+ + P A+ T G + Sbjct: 149 GMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLS-RVLEDDPEATYTTSGGKIPIRWT 207 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 APE + + S++D +S G ++++++ G P+ Sbjct: 208 APEAISYR-KFTSASDVWSFGIVMWEVMTYGERPY 241 >3TT0-A nrPDB Length = 382 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 32/109 (29%), Positives = 59/109 (54%), Gaps = 8/109 (7%) Query: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA-----CDFS 343 S D+ A ++ G+E++ ++ ++RDL N+L+ E ++I+D GLA D+ Sbjct: 188 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 247 Query: 344 KKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 KK + + +MAPE L + Y +D +S G +L+++ G SP+ Sbjct: 248 KKTTNGRLPVK-WMAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPY 294 >3GQL-A nrPDB Length = 326 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 32/109 (29%), Positives = 59/109 (54%), Gaps = 8/109 (7%) Query: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA-----CDFS 343 S D+ A ++ G+E++ ++ ++RDL N+L+ E ++I+D GLA D+ Sbjct: 147 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 206 Query: 344 KKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 KK + + +MAPE L + Y +D +S G +L+++ G SP+ Sbjct: 207 KKTTNGRLPVK-WMAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPY 253 >3PP0-A nrPDB Length = 338 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 101/213 (47%), Gaps = 29/213 (13%) Query: 195 RIIGRGGFGEVY-GCRKADTGKM---YAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 +++G G FG VY G D + A+K L + E L +E +++ V + Sbjct: 23 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEIL--DEAYVMAGVGS-- 78 Query: 251 CPFI-----VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILG 304 P++ +C++ + + LM G L H+ ++ G D+ + +I G Sbjct: 79 -PYVSRLLGICLT------STVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKG 131 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA--CDFSKKKPHASVGTH--GYMAPE 360 + ++ + +V+RDL N+L+ HV+I+D GLA D + + HA G +MA E Sbjct: 132 MSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALE 191 Query: 361 -VLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 +L++ + S D +S G +++L+ G P+ Sbjct: 192 SILRRRFTHQS--DVWSYGVTVWELMTFGAKPY 222 >3RP9-A nrPDB Length = 458 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 49/232 (21%), Positives = 97/232 (41%), Gaps = 45/232 (19%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMK--------CLDKKRIKMKQGETLALNERIM 242 + + +IG G +G V ++ A+K +D KRI + LN + Sbjct: 55 YEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHV 114 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 + ++ + + D+L +L++ + D +E ++ ++ Sbjct: 115 VKVLD-------IVIPKDVEKFDELYVVLEIADS-DFKKLFRTPVYLTELHIKTLLYNLL 166 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA--CDFSKKK-------------- 346 +G++++H+ +++RDLKPAN L+++ V++ D GLA D+ + Sbjct: 167 VGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMN 226 Query: 347 ----PHAS---------VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL 385 PH V T Y APE++ Y + D +S+GC+ +LL Sbjct: 227 LVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELL 278 >4XHH-A nrPDB Length = 403 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 65/251 (25%), Positives = 105/251 (41%), Gaps = 33/251 (13%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F + R IG G FG++Y +G+ A++ L+ R + Q L R+ L Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIR-LESIRSRHPQ---LDYESRVYKYLSGGVG 64 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 PFI + + ++DL+ DL + H FS + A ++I ++++ Sbjct: 65 IPFIRWFG---REGEYNAMVIDLLGPSLEDLFNYC--HRKFSFKTVIMLALQMICRVQYI 119 Query: 309 HNRFVVYRDLKPANILLD---EHGHVRISDLGLACDFSKKKPHASV---------GTHGY 356 H R ++RD+KP N L+ V + D GL+ + H + GT Y Sbjct: 120 HGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARY 179 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHK-TKDKHEIDRM---TLTMAVE 412 + G+ D SLG ML +G P++ K T K + DR+ L ++VE Sbjct: 180 ASVNT-HLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCISVE 238 Query: 413 -----LPDSFS 418 LP FS Sbjct: 239 TLCAGLPLEFS 249 >3V5Q-A nrPDB Length = 297 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 64/277 (23%), Positives = 114/277 (41%), Gaps = 31/277 (11%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM-- 242 H+ D + R +G G FG+V+ A+ + K +K + TLA + Sbjct: 11 HIKRRDIVLKRELGEGAFGKVF---LAECYNLSPTKDKMLVAVKALKDPTLAARKDFQRE 67 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-------------- 288 L++ IV D L + + M GDL+ L HG Sbjct: 68 AELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAK 127 Query: 289 --FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 346 + M A++I G+ ++ ++ V+RDL N L+ + V+I D G++ D Sbjct: 128 GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTD 187 Query: 347 PHASVGTHG-----YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKH 400 + VG H +M PE + + + +D +S G +L+++ G P+ Q + Sbjct: 188 -YYRVGGHTMLPIRWMPPESIMYR-KFTTESDVWSFGVILWEIFTYGKQPWFQ--LSNTE 243 Query: 401 EIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRL 437 I+ +T +E P E+ ++ G QR+ +RL Sbjct: 244 VIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRL 280 >5A46-A nrPDB Length = 386 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 32/109 (29%), Positives = 59/109 (54%), Gaps = 8/109 (7%) Query: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA-----CDFS 343 S D+ A ++ G+E++ ++ ++RDL N+L+ E ++I+D GLA D+ Sbjct: 159 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 218 Query: 344 KKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 KK + + +MAPE L + Y +D +S G +L+++ G SP+ Sbjct: 219 KKTTNGRLPVK-WMAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPY 265 >6FER-A nrPDB Length = 309 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 49/218 (22%), Positives = 97/218 (44%), Gaps = 38/218 (17%) Query: 197 IGRGGFGEVYGCR----------------KADTGKMYAMKCLDKKRIKMKQGETLALNER 240 +G G FGEV+ C A+ + A+K L K + + L Sbjct: 17 LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLK---- 72 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG----------VFS 290 + ++S P I+ + T D L I + M GDL+ LS+H S Sbjct: 73 -EIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVS 131 Query: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGL-----ACDFSKK 345 +++F A +I G++++ + V+RDL N L+ ++ ++I+D G+ + D+ + Sbjct: 132 YTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRI 191 Query: 346 KPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFK 383 + A + +M+ E + G + +++D ++ G L++ Sbjct: 192 QGRAVLPIR-WMSWESILLG-KFTTASDVWAFGVTLWE 227 >5UNP-A nrPDB Length = 369 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 53/239 (22%), Positives = 92/239 (38%), Gaps = 44/239 (18%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALN------------ 238 + + +G G FG V C G + K K K+ L +N Sbjct: 36 YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDN 95 Query: 239 ERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYA 298 + + + + D +C+S+ F+ D L Y + Q +R A Sbjct: 96 KNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKD---NNYLPYPIHQ--------VRHMA 144 Query: 299 AEIILGLEHMHNRFVVYRDLKPANILL---------------DEHG----HVRISDLGLA 339 ++ ++ +H+ + + DLKP NIL DE VR+ D G A Sbjct: 145 FQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA 204 Query: 340 CDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 F + V T Y APEV+ + + + D +S+GC++F+ G + F+ H ++ Sbjct: 205 T-FDHEHHSTIVSTRHYRAPEVILE-LGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNRE 261 >4XCU-A nrPDB Length = 300 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 41/148 (27%), Positives = 72/148 (48%), Gaps = 10/148 (6%) Query: 284 SQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA---- 339 S G S + A ++ G++++ +R ++RDL N+L+ E ++I+D GLA Sbjct: 122 SSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH 181 Query: 340 -CDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTK 397 D+ KK + + +MAPE L V Y +D +S G +L+++ G SP+ + Sbjct: 182 HIDYYKKTSNGRLPVK-WMAPEALFDRV-YTHQSDVWSFGILLWEIFTLGGSPYPGIPVE 239 Query: 398 DKHEIDRMTLTMAVELPDSFSPELRSLL 425 + + R M + P PEL L+ Sbjct: 240 ELFSLLREGHRM--DRPPHCPPELYGLM 265 >2WTK-B nrPDB Length = 373 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 44/192 (22%), Positives = 84/192 (43%), Gaps = 41/192 (21%) Query: 214 GKMYAMKCLDKKRIKMKQGETLALNER-IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILD 272 G+++ K + I + +A NE ++ S ++ G ++C + +D Sbjct: 59 GELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHF-----------MD 107 Query: 273 LMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVR 332 MN E + + ++ L+++H+ V+R +K ++IL+ G V Sbjct: 108 GMN---------------ELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVY 152 Query: 333 ISDLGLACDFSKKK-----------PHASVGTHGYMAPEVLQKGV-AYDSSADWFSLGCM 380 +S GL + S P SV +++PEVLQ+ + YD+ +D +S+G Sbjct: 153 LS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGIT 210 Query: 381 LFKLLRGHSPFR 392 +L GH PF+ Sbjct: 211 ACELANGHVPFK 222 >3KRL-A nrPDB Length = 335 Score = 48.9 bits (115), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 98/228 (42%), Gaps = 29/228 (12%) Query: 189 NDFSVHRIIGRGGFGEV-----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 N+ + +G G FG+V +G K D A+K L K + E L +IM Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADEKEALMSELKIMS 104 Query: 244 SL-----------VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV---F 289 L T P +V Y + D L+F+ G + + H Sbjct: 105 HLGQHENIVNLLGACTHGGPVLVITEYCCYG-DLLNFLRRKRPPGLEYSYNPSHNPEEQL 163 Query: 290 SEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHV-RISDLGLACDFSKKKPH 348 S D+ +++++ G+ + ++ ++RD+ N+LL +GHV +I D GLA D + Sbjct: 164 SSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDSNY 222 Query: 349 ASVGTH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 G +MAPE + V Y +D +S G +L+++ G +P+ Sbjct: 223 IVKGNARLPVKWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPY 269 >6DBN-A nrPDB Length = 316 Score = 48.9 bits (115), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 87/202 (43%), Gaps = 16/202 (7%) Query: 195 RIIGRGGFGEVYGCR----KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 R +G G FG+V CR +TG+ A+K L K L I+ +L Sbjct: 41 RDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL-KPESGGNHIADLKKEIEILRNLYHENI 99 Query: 251 CPFI-VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRF-YAAEIILGLEHM 308 + +C + + I++ + G L +L ++ + YA +I G++++ Sbjct: 100 VKYKGICTE---DGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL 156 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPEVLQ 363 +R V+RDL N+L++ V+I D GL K + +V + APE L Sbjct: 157 GSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLM 216 Query: 364 KGVAYDSSADWFSLGCMLFKLL 385 + Y +S W S G L +LL Sbjct: 217 QSKFYIASDVW-SFGVTLHELL 237 >5GRN-A nrPDB Length = 356 Score = 48.9 bits (115), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 57/233 (24%), Positives = 104/233 (44%), Gaps = 41/233 (17%) Query: 195 RIIGRGGFGEV-----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM------L 243 R++G G FG+V YG ++ A+K L K + + + L +IM L Sbjct: 52 RVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKML-KPTARSSEKQALMSELKIMTHLGPHL 110 Query: 244 SLVST-GDC----PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEA------ 292 ++V+ G C P + Y F+ D ++++ N H + + SE Sbjct: 111 NIVNLLGACTKSGPIYIITEYCFYG-DLVNYLHK--NRDSFLSHKKKSMLDSEVKNLLSD 167 Query: 293 ---------DMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS 343 D+ + ++ G+E + ++ V+RDL N+LL + V+I D GLA D Sbjct: 168 DNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIM 227 Query: 344 KKKPHASVGTH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 + S G+ +MAPE + + Y + +D +S G +L+++ G +P+ Sbjct: 228 HDSNYVSKGSTFLPVKWMAPESIFDNL-YTTLSDVWSYGILLWEIFSLGGTPY 279 >3EB0-A nrPDB Length = 383 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 27/108 (25%), Positives = 55/108 (50%), Gaps = 2/108 (1%) Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGH-VRISDLGLACDFSKKKPH-ASV 351 + Y ++ + +H+ + +RD+KP N+L++ + +++ D G A +P A + Sbjct: 143 ISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGSAKKLIPSEPSVAYI 202 Query: 352 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 399 + Y APE++ Y S D +S+GC+ +L+ G F + D+ Sbjct: 203 CSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGETSIDQ 250 >6FEX-A nrPDB Length = 321 Score = 48.5 bits (114), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 50/222 (22%), Positives = 97/222 (43%), Gaps = 39/222 (17%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM-------------- 242 +G G FGEV+ C + ++ + +++G L + +I+ Sbjct: 24 LGEGQFGEVHLCEVDSPQDLVSLDF----PLNVRKGHPLLVAVKILRPDATKNARNDFLK 79 Query: 243 -LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEAD-------- 293 + ++S P I+ + D L I D M GDL+ LS H + +A Sbjct: 80 EVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDPT 139 Query: 294 -----MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGL-----ACDFS 343 + AA+I G+ ++ V+RDL N L+ E+ ++I+D G+ A D+ Sbjct: 140 ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYY 199 Query: 344 KKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL 385 + + A + +MA E + G + +++D ++ G L+++L Sbjct: 200 RVQGRAVLPIR-WMAWECILMG-KFTTASDVWAFGVTLWEVL 239 >2PSQ-A nrPDB Length = 370 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 29/94 (30%), Positives = 54/94 (57%), Gaps = 8/94 (8%) Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA-----CDFSKKKPHASVGTHGYMA 358 G+E++ ++ ++RDL N+L+ E+ ++I+D GLA D+ KK + + +MA Sbjct: 215 GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVK-WMA 273 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 PE L V Y +D +S G +++++ G SP+ Sbjct: 274 PEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPY 306 >4RT7-A nrPDB Length = 415 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 32/109 (29%), Positives = 56/109 (51%), Gaps = 6/109 (5%) Query: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 347 V + D+ +A ++ G+E + + V+RDL N+L+ V+I D GLA D Sbjct: 239 VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSN 298 Query: 348 HASVGTH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 + G +MAPE L +G+ Y +D +S G +L+++ G +P+ Sbjct: 299 YVVRGNARLPVKWMAPESLFEGI-YTIKSDVWSYGILLWEIFSLGVNPY 346 >2C47-A nrPDB Length = 313 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 63/223 (28%), Positives = 99/223 (44%), Gaps = 34/223 (15%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 +F V + IG G FGE+ + T + A+K L+ + + Q L L R L +T Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQ---LHLEYRFYKQLSATE 60 Query: 250 DCP----FIVCMSYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAAEIIL 303 P F C Y + +L+L+ DL + L F+ + A ++I Sbjct: 61 GVPQVYYFGPCGKYN-------AMVLELLGPSLEDL-FDLCDR-TFTLKTVLMIAIQLIT 111 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVR-----ISDLGLACDF----SKK----KPHAS 350 +E++H + ++YRD+KP N L+ G R I D GLA ++ +KK + H S Sbjct: 112 RMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKS 171 Query: 351 V-GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR 392 + GT YM+ G D +LG M LRG P++ Sbjct: 172 LTGTARYMSINT-HLGKEQSRRDDLEALGHMFMYFLRGSLPWQ 213 >5L2Q-C nrPDB Length = 320 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 6/123 (4%) Query: 272 DLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGH- 330 DL+N L +++ + SE + +++ +E +H + +V+RDLK N++L++ H Sbjct: 136 DLIN---LQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHR 192 Query: 331 VRISDLGLACDFSKKKP--HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGH 388 + I++ L + G+ Y++P+VL +D ++LG +LF +L G Sbjct: 193 ITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQ 252 Query: 389 SPF 391 PF Sbjct: 253 FPF 255 >4R7H-A nrPDB Length = 343 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 59/235 (25%), Positives = 100/235 (42%), Gaps = 36/235 (15%) Query: 189 NDFSVHRIIGRGGFGEV-----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 N+ + +G G FG+V +G K D A+K L K + E L +IM Sbjct: 50 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADEKEALMSELKIMS 108 Query: 244 SL-----------VSTGDCPFIVCMSYAFHTPDKLSFI---LDLMNGGDLHYHLSQHGVF 289 L T P +V Y + D L+F+ + M G L G+ Sbjct: 109 HLGQHENIVNLLGACTHGGPVLVITEYCTYG-DLLNFLRRKAEAMLGPSLSPGQDPEGLD 167 Query: 290 SE-------ADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHV-RISDLGLACD 341 E D+ +++++ G+ + ++ ++RD+ N+LL +GHV +I D GLA D Sbjct: 168 KEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARD 226 Query: 342 FSKKKPHASVGTH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 + G +MAPE + V Y +D +S G +L+++ G +P+ Sbjct: 227 IMNDSNYIVKGNARLPVKWMAPESIFDSV-YTVQSDVWSYGILLWEIFSLGLNPY 280 >5E8V-A nrPDB Length = 316 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 49/213 (23%), Positives = 90/213 (42%), Gaps = 28/213 (13%) Query: 196 IIGRGGFGEVYGCR-KADTGKMY---AMKCLDKKRIKMKQGETLALNERIMLSLVSTGDC 251 ++G+G F EVY + K +T + + A+K + + E ++ ++L Sbjct: 16 LVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSD---INLKHENIL 72 Query: 252 PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNR 311 F+ + I G+L +L++H V S D+R + + G+ H+H+ Sbjct: 73 QFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-VISWEDLRKLGSSLARGIAHLHSD 131 Query: 312 F---------VVYRDLKPANILLDEHGHVRISDLGLACDFSKK------KPHASVGTHGY 356 +V+RDLK +NIL+ + D GL+ VGT Y Sbjct: 132 HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARY 191 Query: 357 MAPEVLQKGVAYDS-----SADWFSLGCMLFKL 384 MAPEVL + ++ D +S+ +L+++ Sbjct: 192 MAPEVLASAMNLENVESFKQTDVYSMALVLWEM 224 >5KMM-A nrPDB Length = 329 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 45/192 (23%), Positives = 86/192 (44%), Gaps = 27/192 (14%) Query: 267 LSFILDLMNGGDLHYHLSQHGVFSE---------------ADMRFYAAEIILGLEHMHNR 311 L + + M GDL+ L HG ++ + A+++ G+ ++ Sbjct: 112 LLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL 171 Query: 312 FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPE-VLQKG 365 V+RDL N L+ + V+I D G++ D + VG +M PE +L + Sbjct: 172 HFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTD-YYRVGGRTMLPIRWMPPESILYR- 229 Query: 366 VAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 424 + + +D +S G +L+++ G P+ Q + ID +T +E P + PE+ ++ Sbjct: 230 -KFTTESDVWSFGVVLWEIFTYGKQPWYQ--LSNTEAIDCITQGRELERPRACPPEVYAI 286 Query: 425 LEGLLQRDVNRR 436 + G QR+ +R Sbjct: 287 MRGCWQREPQQR 298 >5U6B-A nrPDB Length = 307 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 38/134 (28%), Positives = 67/134 (50%), Gaps = 14/134 (10%) Query: 270 ILDLMNGGDLHY-----HLSQHGVFSEADMRF-YAAEIILGLEHMHNRFVVYRDLKPANI 323 IL M GDLH L V+ M + A+I G+E++ + ++RDL N Sbjct: 108 ILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNC 167 Query: 324 LLDEHGHVRISDLGLA-----CDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLG 378 +L+E+ V ++D GL+ D+ ++ A + ++A E L V Y S +D +S G Sbjct: 168 MLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVK-WIAIESLADRV-YTSKSDVWSFG 225 Query: 379 CMLFKL-LRGHSPF 391 ++++ RG +P+ Sbjct: 226 VTMWEIATRGQTPY 239 >1FVR-A nrPDB Length = 327 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/226 (24%), Positives = 96/226 (42%), Gaps = 25/226 (11%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 L ND +IG G FG+V R K D +M A K+ A ++ Sbjct: 22 LDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCK 81 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL----------------SQHGV 288 L G P I+ + A L ++ G+L L S Sbjct: 82 L---GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTAST 138 Query: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA--CDFSKKK 346 S + +AA++ G++++ + ++RDL NIL+ E+ +I+D GL+ + KK Sbjct: 139 LSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKK 198 Query: 347 PHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 + +MA E L V Y +++D +S G +L++++ G +P+ Sbjct: 199 TMGRLPVR-WMAIESLNYSV-YTTNSDVWSYGVLLWEIVSLGGTPY 242 >5EG3-A nrPDB Length = 334 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 29/94 (30%), Positives = 54/94 (57%), Gaps = 8/94 (8%) Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA-----CDFSKKKPHASVGTHGYMA 358 G+E++ ++ ++RDL N+L+ E+ ++I+D GLA DF K+ + + +MA Sbjct: 169 GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFKETTNGRLPVK-WMA 227 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 PE L V Y +D +S G +++++ G SP+ Sbjct: 228 PEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPY 260 >4XHL-A nrPDB Length = 394 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 59/240 (24%), Positives = 100/240 (41%), Gaps = 28/240 (11%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F + R IG G FG++Y +G+ A++ L+ R + Q L R+ L Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIR-LESIRSRHPQ---LDYESRVYRYLSGGVG 64 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 PFI + + ++DL+ DL + H FS + A ++ ++++ Sbjct: 65 IPFIRWFG---REGEYNAMVIDLLGPSLEDLFNYC--HRRFSFKTVIMLALQMFCRIQYI 119 Query: 309 HNRFVVYRDLKPANILLD---EHGHVRISDLGLACDFSKKKPHASV---------GTHGY 356 H R ++RD+KP N L+ V + D GL+ + H + GT Y Sbjct: 120 HGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARY 179 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHK-TKDKHEIDRMT---LTMAVE 412 + G+ D SLG +L +G P++ K T K + DR+ L ++VE Sbjct: 180 ASVNT-HLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVE 238 >4K33-A nrPDB Length = 325 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 31/105 (29%), Positives = 58/105 (55%), Gaps = 8/105 (7%) Query: 293 DMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA-----CDFSKKKP 347 D+ A ++ G+E++ ++ ++RDL N+L+ E ++I+D GLA D+ K+ Sbjct: 159 DLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKETT 218 Query: 348 HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 + + +MAPE L V Y +D +S G +L+++ G SP+ Sbjct: 219 NGRLPVK-WMAPEALFDRV-YTHQSDVWSFGVLLWEIFTLGGSPY 261 >3A4O-X nrPDB Length = 286 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 51/215 (23%), Positives = 94/215 (43%), Gaps = 29/215 (13%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQ-------GETLALNERIMLSLVSTG 249 +G G FGEV+ ++ K+ A+K L + ++ +TL ++ + L V T Sbjct: 21 LGAGQFGEVWMGYYNNSTKV-AVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTR 79 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAEIILGLEH 307 + P + Y + G L + S G V + F +A+I G+ + Sbjct: 80 EEPIYIITEY-------------MAKGSLLDFLKSDEGGKVLLPKLIDF-SAQIAEGMAY 125 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GYMAPEVLQK 364 + + ++RDL+ AN+L+ E +I+D GLA + A G + APE + Sbjct: 126 IERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINF 185 Query: 365 GVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 G + +D +S G +L++++ G P+ D Sbjct: 186 G-CFTIKSDVWSFGILLYEIVTYGKIPYPGRTNAD 219 >4HZS-A nrPDB Length = 341 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 57/219 (26%), Positives = 97/219 (44%), Gaps = 16/219 (7%) Query: 197 IGRGGFGEVY-GCRKADTGKMY--AMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPF 253 +G G FG V G A +GK A+KCL K + Q E + R + ++ S Sbjct: 20 LGDGSFGVVRRGEWDAPSGKTVSVAVKCL--KPDVLSQPEAMDDFIREVNAMHSLDHRNL 77 Query: 254 IVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLEHMHNRF 312 I P K+ + +L G L L +H G F + YA ++ G+ ++ ++ Sbjct: 78 IRLYGVVLTPPMKM--VTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKR 135 Query: 313 VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH-----GYMAPEVLQKGVA 367 ++RDL N+LL V+I D GL + H + H + APE L K Sbjct: 136 FIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL-KTRT 194 Query: 368 YDSSADWFSLGCMLFKLLR-GHSPF-RQHKTKDKHEIDR 404 + ++D + G L+++ G P+ + ++ H+ID+ Sbjct: 195 FSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK 233 >4H1J-A nrPDB Length = 293 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 90/217 (41%), Gaps = 15/217 (6%) Query: 190 DFSVHRIIGRGGFGEVY----GCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 D ++RI+G G FGEVY K + + C KK + E IM +L Sbjct: 25 DVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTC--KKDCTLDNKEKFMSEAVIMKNL 82 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILG 304 D P IV + + I++L G+L ++L ++ + Y+ +I Sbjct: 83 ----DHPHIVKL-IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKA 137 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GYMAPEV 361 + ++ + V+RD+ NIL+ V++ D GL+ + + + T +M+PE Sbjct: 138 MAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPES 197 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 + +S W CM L G PF + KD Sbjct: 198 INFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKD 234 >3KUL-B nrPDB Length = 325 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 100/218 (45%), Gaps = 20/218 (9%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKM---YAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + +IIG G GEV R G+ A+K L + ++ + L+ S++ Sbjct: 53 IEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLS-----EASIMGQF 107 Query: 250 DCPFIVCMSYAFHTPDKLSFIL-DLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLEH 307 D P I+ + T +L+ I+ + M G L L H G F+ + + G+ + Sbjct: 108 DHPNIIRLE-GVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRY 166 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG------YMAPEV 361 + + V+RDL N+L+D + ++SD GL+ + P A+ T G + APE Sbjct: 167 LSDLGYVHRDLAARNVLVDSNLVCKVSDFGLS-RVLEDDPDAAYTTTGGKIPIRWTAPEA 225 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 + + S++D +S G +++++L G P+ +D Sbjct: 226 IAF-RTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRD 262 >3QGY-A nrPDB Length = 286 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 32/140 (22%), Positives = 66/140 (47%), Gaps = 6/140 (4%) Query: 267 LSFILDLMNGGDLHYHL-SQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL 325 + + + M G L +L +Q G+F+ + ++ G+ ++ V++RDL N L+ Sbjct: 97 ICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLV 156 Query: 326 DEHGHVRISDLGLACDFSKKKPHASVGTH---GYMAPEVLQKGVAYDSSADWFSLGCMLF 382 E+ +++SD G+ + +S GT + +PEV Y S +D +S G +++ Sbjct: 157 GENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFS-RYSSKSDVWSFGVLMW 215 Query: 383 KLL-RGHSPFRQHKTKDKHE 401 ++ G P+ + E Sbjct: 216 EVFSEGKIPYENRSNSEVVE 235 >3BEA-A nrPDB Length = 333 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 56/227 (24%), Positives = 100/227 (44%), Gaps = 29/227 (12%) Query: 189 NDFSVHRIIGRGGFGEV-----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 N+ + +G G FG+V +G K D A+K L K + E L +IM Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADEKEALMSELKIMS 104 Query: 244 SL-----------VSTGDCPFIVCMSYAFHTPDKLSFIL--DLMNGGDLHYHLSQHGVFS 290 L T P +V Y + D L+F+ + D + ++ + S Sbjct: 105 HLGQHENIVNLLGACTHGGPVLVITEYCCYG-DLLNFLRRKSRVLETDPAFAIA-NSTLS 162 Query: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHV-RISDLGLACDFSKKKPHA 349 D+ +++++ G+ + ++ ++RD+ N+LL +GHV +I D GLA D + Sbjct: 163 TRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMNDSNYI 221 Query: 350 SVGTH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 G +MAPE + V Y +D +S G +L+++ G +P+ Sbjct: 222 VKGNARLPVKWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPY 267 >3SV0-A nrPDB Length = 483 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 93/227 (40%), Gaps = 24/227 (10%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 N F + R IG G FGE+Y T + A+K + +K K + L ++ + T Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKL---ENVKTKHPQLLYESKIYRILQGGT 63 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAAEIILGLE 306 G I + + D ++DL+ DL S+ S + A ++I +E Sbjct: 64 G----IPNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRK--LSLKTVLMLADQMINRVE 117 Query: 307 HMHNRFVVYRDLKPANILLD---EHGHVRISDLGLACDFSKKKPHASV---------GTH 354 +H++ ++RD+KP N L+ V I D GLA + H + GT Sbjct: 118 FVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTA 177 Query: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE 401 Y + G+ D SLG +L LRG P++ K K + Sbjct: 178 RYASVNT-HLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQ 223 >4F9B-A nrPDB Length = 361 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 54/245 (22%), Positives = 85/245 (34%), Gaps = 60/245 (24%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS---- 244 N F + IG G F VY L ++++ E +AL I S Sbjct: 21 NVFKIEDKIGEGTFSSVY---------------LATAQLQVGPEEKIALKHLIPTSHPIR 65 Query: 245 -------LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFY 297 L G ++ + Y F D + + + L S ++R Y Sbjct: 66 IAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESF---LDILNSLSFQEVREY 122 Query: 298 AAEIILGLEHMHNRFVVYRDLKPANILLDEH-GHVRISDLGLA----------------- 339 + L+ +H +V+RD+KP+N L + + D GLA Sbjct: 123 MLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSE 182 Query: 340 -------------CDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR 386 C +++ GT G+ APEVL K ++ D +S G + LL Sbjct: 183 AQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLS 242 Query: 387 GHSPF 391 G PF Sbjct: 243 GRYPF 247 >1U54-B nrPDB Length = 291 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 58/226 (25%), Positives = 99/226 (43%), Gaps = 16/226 (7%) Query: 190 DFSVHRIIGRGGFGEVY-GCRKADTGKMY--AMKCLDKKRIKMKQGETLALNERIMLSLV 246 D + +G G FG V G A +GK A+KCL K + Q E + R + ++ Sbjct: 19 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCL--KPDVLSQPEAMDDFIREVNAMH 76 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGL 305 S I P K+ + +L G L L +H G F + YA ++ G+ Sbjct: 77 SLDHRNLIRLYGVVLTPPMKM--VTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 134 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH-----GYMAPE 360 ++ ++ ++RDL N+LL V+I D GL + H + H + APE Sbjct: 135 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 194 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF-RQHKTKDKHEIDR 404 L K + ++D + G L+++ G P+ + ++ H+ID+ Sbjct: 195 SL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK 239 >2PL0-A nrPDB Length = 289 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 38/139 (27%), Positives = 66/139 (47%), Gaps = 7/139 (5%) Query: 259 YAFHTPDKLSFILDLMNGGDLHYHL-SQHGV-FSEADMRFYAAEIILGLEHMHNRFVVYR 316 YA T + + I + M G L L + G+ + + AA+I G+ + R ++R Sbjct: 84 YAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHR 143 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GYMAPEVLQKGVAYDSSAD 373 DL+ ANIL+ + +I+D GLA + A G + APE + G + +D Sbjct: 144 DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGT-FTIKSD 202 Query: 374 WFSLGCMLFKLL-RGHSPF 391 +S G +L +++ G P+ Sbjct: 203 VWSFGILLTEIVTHGRIPY 221 >6EQI-C nrPDB Length = 433 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 40/158 (25%), Positives = 67/158 (42%), Gaps = 28/158 (17%) Query: 304 GLEHMHNRFVVYRDLKPANILLD-----EHGHVRISDLGLA-CDFS-------KKKPHAS 350 + HM+ + +RDLK NIL+D + + I+D G CD + + Sbjct: 179 AVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDK 238 Query: 351 VGTHGYMAPEVLQKGVAYDS-----SADWFSLGCMLFKLLRGHSPFRQHK----TKDKHE 401 G MAPE+ S +D +++G + +++ +PF +K E Sbjct: 239 GGNRALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKE 298 Query: 402 IDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGC 439 D ELPD+ +R+L+ +L R N+RL C Sbjct: 299 ED------LPELPDTIPFIIRNLVSNMLSRSTNKRLDC 330 >6BFN-A nrPDB Length = 342 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 72/258 (27%), Positives = 104/258 (40%), Gaps = 47/258 (18%) Query: 174 FCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL----DKKRIKM 229 FC W E I ++FS IG GGFG VY R +YA+K L D + + Sbjct: 10 FC-WPLCE--ISRGTHNFSEELKIGEGGFGCVY--RAVMRNTVYAVKRLKENADLEWTAV 64 Query: 230 KQG---ETLALNERIMLSLVS-TGDCP--FIVCMSYAFHTPDKLSFILDLMNGG---DLH 280 KQ E L+ ++V G C C+ Y F L NG LH Sbjct: 65 KQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGF-----------LPNGSLEDRLH 113 Query: 281 YHLSQHGVFS---EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLG 337 S D+ A I L H + +++ D+K +N+LLDE ++ D G Sbjct: 114 CQTQACPPLSWPQRLDILLGTARAIQFL-HQDSPSLIHGDIKSSNVLLDERLTPKLGDFG 172 Query: 338 LA--CDFSKKKPHASV---------GTHGYMAPEVLQKG-VAYDSSADWFSLGCMLFKLL 385 LA F+ P S GT Y+ E ++ G +A D+ D FS G ++ + L Sbjct: 173 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDT--DTFSFGVVVLETL 230 Query: 386 RGHSPFRQHKTKDKHEID 403 G + H + K+ D Sbjct: 231 AGQRAVKTHGARTKYLKD 248 >5WNO-A nrPDB Length = 330 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 27/111 (24%), Positives = 55/111 (49%), Gaps = 6/111 (5%) Query: 296 FYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH- 354 Y +I G++++ + VV+RDL N+L+ + HV I+D GL+ ++ + Sbjct: 128 LYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGK 187 Query: 355 ---GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHE 401 ++A E+ K Y ++D ++ G ++++ G SP++ T H Sbjct: 188 VAIKWLAIEIFSKH-CYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHN 237 >2OGV-A nrPDB Length = 317 Score = 46.2 bits (108), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 98/232 (42%), Gaps = 43/232 (18%) Query: 189 NDFSVHRIIGRGGFGEV-----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 N+ + +G G FG+V +G K D A+K L K + E L +IM Sbjct: 38 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADEKEALMSELKIMS 96 Query: 244 SL-----------VSTGDCPFIVCMSYAFHTPDKLSFI-------LDLMNGGDLHYHLSQ 285 L T P +V Y + D L+F+ LD +G L Sbjct: 97 HLGQHENIVNLLGACTHGGPVLVITEYCCYG-DLLNFLRRKAEADLDKEDGRPLELR--- 152 Query: 286 HGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHV-RISDLGLACDFSK 344 D+ +++++ G+ + ++ ++RD+ N+LL +GHV +I D GLA D Sbjct: 153 -------DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL-TNGHVAKIGDFGLARDIMN 204 Query: 345 KKPHASVGTH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 + G +MAPE + V Y +D +S G +L+++ G +P+ Sbjct: 205 DSNYIVKGNARLPVKWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPY 255 >2CHL-A nrPDB Length = 351 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 95/219 (43%), Gaps = 26/219 (11%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 +F V + IG G FGE+ + T + A+K K + L L R L S Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMK----SRAPQLHLEYRFYKQLGSGD 86 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLH--YHLSQHGVFSEADMRFYAAEIILGLEH 307 P + Y F K + ++ + G L + L FS + A ++I +E+ Sbjct: 87 GIPQV----YYFGPCGKYNAMVLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEY 141 Query: 308 MHNRFVVYRDLKPANILLDEHGH-----VRISDLGLACDF----SKK----KPHASV-GT 353 +H++ ++YRD+KP N L+ G+ + I D LA ++ +KK + H S+ GT Sbjct: 142 VHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGT 201 Query: 354 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR 392 YM+ G D +LG M LRG P++ Sbjct: 202 ARYMSINT-HLGKEQSRRDDLEALGHMFMYFLRGSLPWQ 239 >5IKW-A nrPDB Length = 310 Score = 45.8 bits (107), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 31/96 (32%), Positives = 50/96 (52%), Gaps = 12/96 (12%) Query: 313 VVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASV--------GTHGYMAPEV- 361 +++RDLK NILL++ G+ + D G A + + +K +V T Y APE+ Sbjct: 141 IIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMI 200 Query: 362 -LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKT 396 L G + AD ++LGC+L+KL PF + + Sbjct: 201 NLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQV 236 >2PZI-A nrPDB Length = 681 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 49/93 (52%), Gaps = 5/93 (5%) Query: 292 ADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV 351 A+ Y EI+ L ++H+ +VY DLKP NI+L E +++ DLG + Sbjct: 182 AEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFG--YLY 238 Query: 352 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKL 384 GT G+ APE+++ G + D +++G L L Sbjct: 239 GTPGFQAPEIVRTGPTV--ATDIYTVGRTLAAL 269 >3BBT-B nrPDB Length = 328 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 52/215 (24%), Positives = 106/215 (49%), Gaps = 19/215 (8%) Query: 195 RIIGRGGFGEVY---GCRKADTGKM-YAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 +++G G FG VY + +T K+ A+K L++ E + +E ++++ + D Sbjct: 21 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFM--DEALIMA---SMD 75 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH--GVFSEADMRFYAAEIILGLEHM 308 P +V + +P + + LM G L ++ +H + S+ + + +I G+ ++ Sbjct: 76 HPHLVRLLGVCLSP-TIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLN-WCVQIAKGMMYL 133 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLA--CDFSKKKPHASVGTH--GYMAPEVLQK 364 R +V+RDL N+L+ HV+I+D GLA + +K+ +A G +MA E + Sbjct: 134 EERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHY 193 Query: 365 GVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 + +D +S G +++L+ G P+ T++ Sbjct: 194 R-KFTHQSDVWSYGVTIWELMTFGGKPYDGIPTRE 227 >5MJB-A nrPDB Length = 305 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 60/256 (23%), Positives = 109/256 (42%), Gaps = 20/256 (7%) Query: 193 VHRIIGRGGFGEVYGCRKADTGK---MYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + +IG G FGEVY R GK A+K L + ++ + L+ S++ Sbjct: 30 IEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLS-----EASIMGQF 84 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLEHM 308 D I+ + + I + M L L Q+ G F+ + I G++++ Sbjct: 85 DHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL 144 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLA----CDFSKKKPHASVGTH---GYMAPEV 361 V+RDL NIL++ + ++SD GL+ D S +S+G + APE Sbjct: 145 SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEA 204 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 + + S++D +S G ++++++ G P+ +D I+ + + P Sbjct: 205 IAYR-KFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDV--INAIEQDYRLPPPMDCPAA 261 Query: 421 LRSLLEGLLQRDVNRR 436 L L+ Q+D N R Sbjct: 262 LHQLMLDCWQKDRNSR 277 >3G0E-A nrPDB Length = 336 Score = 45.4 bits (106), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 59/232 (25%), Positives = 92/232 (39%), Gaps = 35/232 (15%) Query: 189 NDFSVHRIIGRGGFGEV-----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 N S + +G G FG+V YG K+D A+K L K + + E L ++E +L Sbjct: 46 NRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KPSAHLTEREAL-MSELKVL 103 Query: 244 SLVST--------GDC----PFIVCMSYA-------FHTPDKLSFILDLMNGGDLHYHLS 284 S + G C P +V Y F + SFI + + Sbjct: 104 SYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDEL 163 Query: 285 QHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK 344 + + A+ G+ + ++ ++RDL NILL +I D GLA D Sbjct: 164 ALDLEDLLSFSYQVAK---GMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKN 220 Query: 345 KKPHASVGTH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 + G +MAPE + V Y +D +S G L++L G SP+ Sbjct: 221 DSNYVVKGNARLPVKWMAPESIFNCV-YTFESDVWSYGIFLWELFSLGSSPY 271 >2VWV-A nrPDB Length = 302 Score = 45.4 bits (106), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 57/256 (22%), Positives = 106/256 (41%), Gaps = 20/256 (7%) Query: 193 VHRIIGRGGFGEVYGCRKADTGK---MYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + +IG G FGEV R GK A+K L + ++ E L+ S++ Sbjct: 20 IEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLS-----EASIMGQF 74 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADMRFYAAEIILGLEHM 308 + P I+ + + + + M G L L G F+ + I G+ ++ Sbjct: 75 EHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYL 134 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLA--CDFSKKKPHASVGTHG-----YMAPEV 361 V+RDL NIL++ + ++SD GL+ + + P + G + APE Sbjct: 135 AEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEA 194 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 + + S++D +S G ++++++ G P+ +D I+ + + P Sbjct: 195 IAFR-KFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDV--INAIEQDYRLPPPPDCPTS 251 Query: 421 LRSLLEGLLQRDVNRR 436 L L+ Q+D N R Sbjct: 252 LHQLMLDCWQKDRNAR 267 >4Y12-A nrPDB Length = 375 Score = 45.4 bits (106), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 49/93 (52%), Gaps = 5/93 (5%) Query: 292 ADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV 351 A+ Y EI+ L ++H+ +VY DLKP NI+L E +++ DLG + Sbjct: 221 AEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFG--YLY 277 Query: 352 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKL 384 GT G+ APE+++ G + D +++G L L Sbjct: 278 GTPGFQAPEIVRTGPTV--ATDIYTVGRTLAAL 308 >5M07-A nrPDB Length = 276 Score = 45.4 bits (106), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 64/269 (23%), Positives = 111/269 (41%), Gaps = 51/269 (18%) Query: 178 KNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-------DKKRIKMK 230 ++ L +T ++V R++G GEVY + A+K L D+ R + + Sbjct: 19 SHMALASGVTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQ 78 Query: 231 QGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH--GV 288 + +A R+ P I+ + +L +D ++G D H++ V Sbjct: 79 RETEVA--ARLF--------HPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAV 128 Query: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEH--GHVRI--SDLGLACDFSK 344 ++ + L++ H R +++RD+ PAN++L G RI +D G+A S Sbjct: 129 LPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQPS- 187 Query: 345 KKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDR 404 Y APE L G D AD ++L L G P +DR Sbjct: 188 -----------YPAPE-LSAGADVDGRADQYALALTAIHLFAGAPP-----------VDR 224 Query: 405 MTLTMAVELP--DSFSPELRSLLEGLLQR 431 + T ++ P +F P+L + L+G+L R Sbjct: 225 -SHTGPLQPPKLSAFRPDL-ARLDGVLSR 251 >5U6C-A nrPDB Length = 315 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/153 (26%), Positives = 74/153 (48%), Gaps = 22/153 (14%) Query: 255 VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEAD----------MRFYAAEIILG 304 VC+ + K IL M GDLH +L ++S + + + +I LG Sbjct: 106 VCIEMSSQGIPKPMVILPFMKYGDLHTYL----LYSRLETGPKHIPLQTLLKFMVDIALG 161 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGL-----ACDFSKKKPHASVGTHGYMAP 359 +E++ NR ++RDL N +L + V ++D GL + D+ ++ A + ++A Sbjct: 162 MEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK-WIAI 220 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKL-LRGHSPF 391 E L V Y S +D ++ G ++++ RG +P+ Sbjct: 221 ESLADRV-YTSKSDVWAFGVTMWEIATRGMTPY 252 >6GQK-A nrPDB Length = 328 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 58/229 (25%), Positives = 97/229 (42%), Gaps = 31/229 (13%) Query: 189 NDFSVHRIIGRGGFGEVY-----GCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 N S + +G G FG+V G K+D A+K L K + E L ++E +L Sbjct: 41 NRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKML-KPSAHSTEREAL-MSELKVL 98 Query: 244 SLVST--------GDC----PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSE 291 S + G C P +V Y + D L+F L + Y ++ ++ + Sbjct: 99 SYLGNHENIVNLLGACTHGGPTLVITEYCCYG-DLLNF-LRRKRDEFVPYKVAPEDLYKD 156 Query: 292 ----ADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 347 + ++ ++ G+ + ++ ++RDL NILL +I D GLA D Sbjct: 157 FLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSN 216 Query: 348 HASVGTH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 + G +MAPE + V Y +D +S G L++L G SP+ Sbjct: 217 YVDKGNARLPVKWMAPESIFNSV-YTFESDVWSYGIFLWELFSLGSSPY 264 >4Y93-A nrPDB Length = 446 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 32/149 (21%), Positives = 69/149 (46%), Gaps = 7/149 (4%) Query: 259 YAFHTPDKLSFILD--LMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 Y T + FI+ + NG L+Y F + ++ +E++ ++ ++R Sbjct: 249 YGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHR 308 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GYMAPEVLQKGVAYDSSAD 373 DL N L+++ G V++SD G+ + +S G+ + +PEVL + S +D Sbjct: 309 DLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYS-KFSSKSD 367 Query: 374 WFSLGCMLFKLLR-GHSPFRQHKTKDKHE 401 ++ G +++++ G P+ + + E Sbjct: 368 IWAFGVLMWEIYSLGKMPYERFTNSETAE 396 >1LUF-A nrPDB Length = 343 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 51/232 (21%), Positives = 93/232 (40%), Gaps = 30/232 (12%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 N+ R IG G FG V+ R + K +K + + + + +L++ Sbjct: 47 NNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAE 106 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL---SQHGV----------------- 288 D P IV + + + + M GDL+ L S H V Sbjct: 107 FDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSP 166 Query: 289 ----FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK 344 S A+ A ++ G+ ++ R V+RDL N L+ E+ V+I+D GL+ + Sbjct: 167 GPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYS 226 Query: 345 KKPHASVGTHG----YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 + + G +M PE + Y + +D ++ G +L+++ G P+ Sbjct: 227 ADYYKADGNDAIPIRWMPPESIFYN-RYTTESDVWAYGVVLWEIFSYGLQPY 277 >2CMW-A nrPDB Length = 310 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 59/220 (26%), Positives = 99/220 (45%), Gaps = 25/220 (11%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 V + IG G FGE+ + T + A+K L+ + + Q L L R L S G+ Sbjct: 4 VGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQ---LHLEYRFYKQLGSAGEG- 58 Query: 253 FIVCMSYAFHTPDKLSFILDLMNGGDLH--YHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 + Y F K + ++ + G L + L F+ + A +++ +E++H+ Sbjct: 59 --LPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR-TFTLKTVLMIAIQLLSRMEYVHS 115 Query: 311 RFVVYRDLKPANILLDEHGH-----VRISDLGLACDF----SKK----KPHASV-GTHGY 356 + ++YRD+KP N L+ G+ + I D GLA ++ +KK + H S+ GT Y Sbjct: 116 KNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 175 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKT 396 M+ G D +LG M LRG P++ K Sbjct: 176 MSINT-HLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKA 214 >2HK5-A nrPDB Length = 270 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 28/99 (28%), Positives = 51/99 (51%), Gaps = 5/99 (5%) Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH-- 354 ++A+I G+ + R ++RDL+ ANIL+ +I+D GLA + A G Sbjct: 116 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP 175 Query: 355 -GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 + APE + G ++ +D +S G +L +++ G P+ Sbjct: 176 IKWTAPEAINFG-SFTIKSDVWSFGILLMEIVTYGRIPY 213 >6E4F-A nrPDB Length = 290 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/149 (22%), Positives = 70/149 (46%), Gaps = 7/149 (4%) Query: 259 YAFHTPDKLSFILD--LMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 Y T + FI+ + NG L+Y F + ++ +E++ ++ ++R Sbjct: 92 YGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHR 151 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GYMAPEVLQKGVAYDSSAD 373 DL N L+++ G V++SD GL+ + +SVG+ + PEVL + S +D Sbjct: 152 DLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYS-KFSSKSD 210 Query: 374 WFSLGCMLFKLLR-GHSPFRQHKTKDKHE 401 ++ G +++++ G P+ + + E Sbjct: 211 IWAFGVLMWEIYSLGKMPYERFTNSETAE 239 >6BSD-A nrPDB Length = 876 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 51/228 (22%), Positives = 97/228 (42%), Gaps = 45/228 (19%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM-------------- 242 +G G FGEV+ C + ++ + +++G L + +I+ Sbjct: 579 LGEGQFGEVHLCEVDSPQDLVSLDF----PLNVRKGHPLLVAVKILRPDATKNARNDFLK 634 Query: 243 -LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-------------GV 288 + ++S P I+ + D L I D M GDL+ LS H G Sbjct: 635 EVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQ 694 Query: 289 FSEADMRFY------AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGL---- 338 ++ Y AA+I G+ ++ V+RDL N L+ E+ ++I+D G+ Sbjct: 695 AAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNL 754 Query: 339 -ACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL 385 A D+ + + A + +MA E + G + +++D ++ G L+++L Sbjct: 755 YAGDYYRVQGRAVLPIR-WMAWECILMG-KFTTASDVWAFGVTLWEVL 800 >4BTK-A nrPDB Length = 337 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 55/232 (23%), Positives = 99/232 (42%), Gaps = 25/232 (10%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 ++ + + V + IG GGFGE+Y T + A+K ++ K + L + ++ Sbjct: 52 YVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPK----QVLKMEVAVLKK 107 Query: 245 LVSTGD-CPFIVCMSYAFHTPDKLSFILDLMNGGDL-HYHLSQ-HGVFSEADMRFYAAEI 301 L C FI C +K ++++ + G +L SQ G F+ + +I Sbjct: 108 LQGKDHVCRFIGC-----GRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQI 162 Query: 302 ILGLEHMHNRFVVYRDLKPANILL----DEHGHVRISDLGLACDFSK-----KKPHASVG 352 + +E +H+ ++RD+KP+N + + + D GLA ++ + P G Sbjct: 163 LESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAG 222 Query: 353 THGYM--APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI 402 G + A K D +SL ML + G P+R K KDK ++ Sbjct: 223 FRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWR--KIKDKEQV 272 >6NPU-A nrPDB Length = 298 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/216 (21%), Positives = 93/216 (43%), Gaps = 28/216 (12%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQ--GETLALNE-----RI 241 D ++ +G G +GEVY A+K L + +++++ E + E + Sbjct: 26 TDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLV 85 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADMRFYAA 299 L V T + PF + I + M G+L +L + + + + A Sbjct: 86 QLLGVCTREPPFYI--------------ITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 131 Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GY 356 +I +E++ + ++RDL N L+ E+ V+++D GL+ + A G + Sbjct: 132 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 191 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 APE L + +D ++ G +L+++ G SP+ Sbjct: 192 TAPESLAYN-KFSIKSDVWAFGVLLWEIATYGMSPY 226 >4XI2-A nrPDB Length = 446 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/226 (20%), Positives = 95/226 (42%), Gaps = 32/226 (14%) Query: 190 DFSVHRIIGRGGFGEV-YGCRKAD---------TGKMYAMKCLDKKRIKMKQGETLALNE 239 D + + +G G FG V YG + G M + +++ ++ M L+ + Sbjct: 188 DLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMM----NLSHEK 243 Query: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAA 299 + L V T P + Y + NG L+Y F + Sbjct: 244 LVQLYGVCTKQRPIFIITEY-------------MANGCLLNYLREMRHRFQTQQLLEMCK 290 Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GY 356 ++ +E++ ++ ++RDL N L+++ G V++SD GL+ + +SVG+ + Sbjct: 291 DVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRW 350 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHE 401 PEVL + S +D ++ G +++++ G P+ + + E Sbjct: 351 SPPEVLMYS-KFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAE 395 >5X8I-B nrPDB Length = 346 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 53/227 (23%), Positives = 93/227 (40%), Gaps = 32/227 (14%) Query: 197 IGRGGFGEVYGC--RKADTGKMYAMKCLDK--KRIKMKQGETLALNERIMLSLVSTGDCP 252 +G G FG+V C KA G+ A+K + + + + E L ST C Sbjct: 21 LGEGAFGKVVECIDHKAG-GRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRC- 78 Query: 253 FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEIILGLEHMHN 310 V M F + + +L+ G + + ++G F +R A +I + +H+ Sbjct: 79 --VQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHS 135 Query: 311 RFVVYRDLKPANILLDEHGH-------------------VRISDLGLACDFSKKKPHASV 351 + + DLKP NIL + + +++ D G A + + V Sbjct: 136 NKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSAT-YDDEHHSTLV 194 Query: 352 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 T Y APEV+ + + D +S+GC+L + G + F H +K+ Sbjct: 195 STRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKE 240 >2DQ7-X nrPDB Length = 283 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 50/202 (24%), Positives = 87/202 (43%), Gaps = 18/202 (8%) Query: 197 IGRGGFGEVY-GCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 +G G FGEV+ G +T A+K L + E+ +IM L + Sbjct: 17 LGNGQFGEVWMGTWNGNT--KVAIKTLKPGTM---SPESFLEEAQIMKKLKHDK-----L 66 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHL--SQHGVFSEADMRFYAAEIILGLEHMHNRFV 313 YA + + + + + MN G L L + ++ AA++ G+ ++ Sbjct: 67 VQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNY 126 Query: 314 VYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GYMAPEVLQKGVAYDS 370 ++RDL+ ANIL+ +I+D GLA + A G + APE G + Sbjct: 127 IHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG-RFTI 185 Query: 371 SADWFSLGCMLFKLL-RGHSPF 391 +D +S G +L +L+ +G P+ Sbjct: 186 KSDVWSFGILLTELVTKGRVPY 207 >4NFN-A nrPDB Length = 309 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 55/232 (23%), Positives = 99/232 (42%), Gaps = 25/232 (10%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 ++ + + V + IG GGFGE+Y T + A+K ++ K + L + ++ Sbjct: 17 YVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPK----QVLKMEVAVLKK 72 Query: 245 LVSTGD-CPFIVCMSYAFHTPDKLSFILDLMNGGDL-HYHLSQ-HGVFSEADMRFYAAEI 301 L C FI C +K ++++ + G +L SQ G F+ + +I Sbjct: 73 LQGKDHVCRFIGC-----GRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQI 127 Query: 302 ILGLEHMHNRFVVYRDLKPANILL----DEHGHVRISDLGLACDFSK-----KKPHASVG 352 + +E +H+ ++RD+KP+N + + + D GLA ++ + P G Sbjct: 128 LESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAG 187 Query: 353 THGYM--APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI 402 G + A K D +SL ML + G P+R K KDK ++ Sbjct: 188 FRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWR--KIKDKEQV 237 >6FYV-A nrPDB Length = 337 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 32/129 (24%), Positives = 56/129 (43%), Gaps = 21/129 (16%) Query: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHV----------------- 331 F +R A +I + +H+ + + DLKP NIL + +V Sbjct: 115 FQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNT 174 Query: 332 --RISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHS 389 ++ D G A + + V T Y APEV+ + + D +S+GC+L + G + Sbjct: 175 DIKVVDFGSAT-YDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFT 232 Query: 390 PFRQHKTKD 398 F+ H +K+ Sbjct: 233 VFQTHDSKE 241 >6J6I-B nrPDB Length = 351 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 46/95 (48%), Gaps = 8/95 (8%) Query: 300 EIILGLEHMHNRF---VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS----VG 352 EI + ++H F +++RD+KP ++ LD++ ++SDL + + K +G Sbjct: 171 EIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLG 230 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRG 387 T GY+ P + K D +S G L ++ G Sbjct: 231 TFGYIDP-LYHKTCFVTEYTDVYSFGICLLVIITG 264 >5X18-A nrPDB Length = 295 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 33/127 (25%), Positives = 55/127 (43%), Gaps = 15/127 (11%) Query: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHG-----HVRISDLGLACDFS 343 FS + A ++I +E +H ++YRD+KP N L+ G ++ + D G+A + Sbjct: 100 FSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYR 159 Query: 344 KKKPHASV---------GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQH 394 K + GT YM+ G D +LG + F LRGH P++ Sbjct: 160 DPKTKQHIPYREKKSLSGTARYMSINT-HLGREQSRRDDMEALGHVFFYFLRGHLPWQGL 218 Query: 395 KTKDKHE 401 K + + Sbjct: 219 KAPNNKQ 225 >5UU1-A nrPDB Length = 324 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 44/169 (26%), Positives = 72/169 (42%), Gaps = 19/169 (11%) Query: 258 SYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRD 317 SY F ++L L ++G Q+G F ++ + ++ LE++H V+ D Sbjct: 104 SYRFMVMERLGIDLQKISG--------QNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGD 155 Query: 318 LKPANILLDEHG--HVRISDLGLACDFSKKKPHASV------GTHGYMAPEVL--QKGVA 367 +K AN+LL V ++D GL+ + H G +G + L KGVA Sbjct: 156 IKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVA 215 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 +D LG + + L G P+ Q+ KD + + ELP S Sbjct: 216 LSRRSDVEILGYCMLRWLCGKLPWEQN-LKDPVAVQTAKTNLLDELPQS 263 >5AMN-A nrPDB Length = 299 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 37/155 (23%), Positives = 78/155 (50%), Gaps = 10/155 (6%) Query: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK--- 344 + D+ +A +I G++++ +V+RDL NIL+ E ++ISD GL+ D + Sbjct: 132 ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDS 191 Query: 345 --KKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHE 401 K+ + +MA E L + Y + +D +S G +L++++ G +P+ + Sbjct: 192 YVKRSQGRIPVK-WMAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPY--PGIPPERL 247 Query: 402 IDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + + +E PD+ S E+ L+ +++ ++R Sbjct: 248 FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKR 282 >6F3F-A nrPDB Length = 455 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 39/142 (27%), Positives = 67/142 (47%), Gaps = 13/142 (9%) Query: 259 YAFHTPDKLSFILDLMNGGDLHYHL-SQHGVFSE----ADMRFYAAEIILGLEHMHNRFV 313 YA + + + + + MN G L L + G + DM +A+I G+ ++ Sbjct: 248 YAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDM---SAQIASGMAYVERMNY 304 Query: 314 VYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GYMAPEVLQKGVAYDS 370 V+RDL+ ANIL+ E+ +++D GLA + A G + APE G + Sbjct: 305 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG-RFTI 363 Query: 371 SADWFSLGCMLFKL-LRGHSPF 391 +D +S G +L +L +G P+ Sbjct: 364 KSDVWSFGILLTELTTKGRVPY 385 >4JRN-A nrPDB Length = 372 Score = 42.7 bits (99), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 42/165 (25%), Positives = 71/165 (43%), Gaps = 20/165 (12%) Query: 277 GDLHYHLSQHGVFSEADMRFY-AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISD 335 GD + S+ G+ +R Y +++ I + ++ + +V+ D+KPAN LL + G + + D Sbjct: 190 GDASVNKSEFGLV----VRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGD 245 Query: 336 LGLACDFSKKKPHASVGTHGYMAPE--VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQ 393 G ++GT GY PE G+ Y D + LG L+ + P Sbjct: 246 FGTY--RINNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPA 303 Query: 394 HKTKDKHEIDRMTLTMAVELPDSFSPEL-RSLLEGLLQRDVNRRL 437 D + P +PEL + L+ LL RD +R+ Sbjct: 304 DGIWDYLHF--------ADCPS--TPELVQDLIRSLLNRDPQKRM 338 >5SYS-A nrPDB Length = 286 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 30/98 (30%), Positives = 50/98 (51%), Gaps = 5/98 (5%) Query: 298 AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH--- 354 AA+I G+ ++ V+RDL+ ANIL+ E+ +++D GLA + A G Sbjct: 120 AAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 179 Query: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFKL-LRGHSPF 391 + APE G + +D +S G +L +L +G P+ Sbjct: 180 KWTAPEAALYG-RFTIKSDVWSFGILLTELTTKGRVPY 216 >5FM2-A nrPDB Length = 355 Score = 42.4 bits (98), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 36/154 (23%), Positives = 77/154 (50%), Gaps = 8/154 (5%) Query: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 347 + D+ +A +I G++++ +V+RDL NIL+ E ++ISD GL+ D ++ Sbjct: 187 ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDS 246 Query: 348 HASVGTH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEI 402 + +MA E L + Y + +D +S G +L++++ G +P+ + Sbjct: 247 YVKRSQGRIPVKWMAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPY--PGIPPERLF 303 Query: 403 DRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + + +E PD+ S E+ L+ +++ ++R Sbjct: 304 NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKR 337 >3G2F-A nrPDB Length = 336 Score = 42.4 bits (98), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 50/233 (21%), Positives = 92/233 (39%), Gaps = 46/233 (19%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK----QGETLALNERI 241 L +++ + +IGRG +G VY LD++ + +K +NE+ Sbjct: 10 LDLDNLKLLELIGRGRYGAVYK------------GSLDERPVAVKVFSFANRQNFINEKN 57 Query: 242 M--LSLVSTGDCPFIVCMSYAFHTPDKLSFIL--DLMNGGDLHYHLSQHGVFSEADMRFY 297 + + L+ + + ++ ++L + G L +LS H + R Sbjct: 58 IYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRL- 116 Query: 298 AAEIILGLEHMHNRF---------VVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-- 346 A + GL ++H + +RDL N+L+ G ISD GL+ + + Sbjct: 117 AHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLV 176 Query: 347 --------PHASVGTHGYMAPEVLQKGVAYDS------SADWFSLGCMLFKLL 385 + VGT YMAPEVL+ V D ++LG + +++ Sbjct: 177 RPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIF 229 >4XEY-B nrPDB Length = 408 Score = 42.4 bits (98), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 47/216 (21%), Positives = 93/216 (43%), Gaps = 28/216 (12%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQ--GETLALNE-----RI 241 D ++ +G G +GEVY A+K L + +++++ E + E + Sbjct: 125 TDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLV 184 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADMRFYAA 299 L V T + PF + I + M G+L +L + + + + A Sbjct: 185 QLLGVCTREPPFYI--------------ITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 230 Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GY 356 +I +E++ + ++RDL N L+ E+ V+++D GL+ + A G + Sbjct: 231 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 290 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 APE L + +D ++ G +L+++ G SP+ Sbjct: 291 TAPESLAYN-KFSIKSDVWAFGVLLWEIATYGMSPY 325 >3QUP-A nrPDB Length = 323 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 52/225 (23%), Positives = 99/225 (44%), Gaps = 33/225 (14%) Query: 191 FSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRIKMKQGETLA-------LNERIM 242 F++ R++G+G FG V + K + G K +KM + + +A L E Sbjct: 25 FTLGRMLGKGEFGSVREAQLKQEDGSFV------KVAVKMLKADIIASSDIEEFLREAAC 78 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSF---ILDLMNGGDLHYHLSQHGVFS-------EA 292 + +V +S +L IL M GDLH L + + Sbjct: 79 MKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQT 138 Query: 293 DMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGL-----ACDFSKKKP 347 +RF +I G+E++ +R ++RDL N +L E V ++D GL + D+ ++ Sbjct: 139 LVRFMV-DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGC 197 Query: 348 HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL-RGHSPF 391 + + ++A E L + Y +D ++ G +++++ RG +P+ Sbjct: 198 ASKLPVK-WLALESLADNL-YTVHSDVWAFGVTMWEIMTRGQTPY 240 >5L6P-A nrPDB Length = 298 Score = 42.0 bits (97), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 48/219 (21%), Positives = 92/219 (42%), Gaps = 20/219 (9%) Query: 193 VHRIIGRGGFGEVYGCRKADTGK---MYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + +IG G FGEV R G+ A+K L + ++ + L+ S++ Sbjct: 23 IEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLS-----EASIMGQF 77 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADMRFYAAEIILGLEHM 308 D P I+ + + + + M L L G F+ + I G++++ Sbjct: 78 DHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYL 137 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG--------YMAPE 360 V+RDL NIL++ + ++SD GL+ F + P T + APE Sbjct: 138 SEMNYVHRDLAARNILVNSNLVCKVSDFGLS-RFLEDDPSDPTYTSSLGGKIPIRWTAPE 196 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 + + S++D +S G ++++++ G P+ +D Sbjct: 197 AIAYR-KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQD 234 >2H8H-A nrPDB Length = 535 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/98 (30%), Positives = 50/98 (51%), Gaps = 5/98 (5%) Query: 298 AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH--- 354 AA+I G+ ++ V+RDL+ ANIL+ E+ +++D GLA + A G Sbjct: 369 AAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 428 Query: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFKL-LRGHSPF 391 + APE G + +D +S G +L +L +G P+ Sbjct: 429 KWTAPEAALYG-RFTIKSDVWSFGILLTELTTKGRVPY 465 >4NT4-A nrPDB Length = 312 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/118 (28%), Positives = 54/118 (45%), Gaps = 15/118 (12%) Query: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVR-----ISDLGLA---- 339 FS + A +++ +E++H+R ++YRD+KP N L+ R I D GLA Sbjct: 111 FSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYI 170 Query: 340 -CDFSKKKPH----ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR 392 D ++ P+ + GT YM+ G D +LG M LRG P++ Sbjct: 171 DLDTNRHIPYREHKSLTGTARYMSINT-HMGREQSRRDDLEALGHMFMYFLRGSLPWQ 227 >1AD5-A nrPDB Length = 438 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 28/99 (28%), Positives = 50/99 (50%), Gaps = 15/99 (15%) Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH-- 354 ++A+I G+ + R ++RDL+ ANIL+ +I+D GL A VG Sbjct: 283 FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGL----------ARVGAKFP 332 Query: 355 -GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 + APE + G ++ +D +S G +L +++ G P+ Sbjct: 333 IKWTAPEAINFG-SFTIKSDVWSFGILLMEIVTYGRIPY 370 >3SXS-A nrPDB Length = 268 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/186 (25%), Positives = 80/186 (43%), Gaps = 28/186 (15%) Query: 267 LSFILDLMNGGDLHYHLSQHGVFSE-ADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL 325 + + + ++ G L +L HG E + + ++ G+ + + ++RDL N L+ Sbjct: 78 IYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLV 137 Query: 326 DEHGHVRISDLGLACDFSKKKPHASVGTH---GYMAPEVLQKGVAYDSSAD-W------- 374 D V++SD G+ + +SVGT + APEV Y S +D W Sbjct: 138 DRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHY-FKYSSKSDVWAFGILMW 196 Query: 375 --FSLGCM----------LFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 FSLG M + K+ +GH +R H D I ++ + ELP+ P + Sbjct: 197 EVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDT--IYQIMYSCWHELPEK-RPTFQ 253 Query: 423 SLLEGL 428 LL + Sbjct: 254 QLLSSI 259 >2XYN-A nrPDB Length = 292 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/216 (21%), Positives = 92/216 (42%), Gaps = 28/216 (12%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQ--GETLALNE-----RI 241 D ++ +G G +GEVY A+K L + +++++ E + E + Sbjct: 32 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLV 91 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAA 299 L V T + PF + Y M G+L +L + + + + A Sbjct: 92 QLLGVCTLEPPFYIVTEY--------------MPYGNLLDYLRECNREEVTAVVLLYMAT 137 Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GY 356 +I +E++ + ++RDL N L+ E+ V+++D GL+ + A G + Sbjct: 138 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 197 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPF 391 APE L + +D ++ G +L+++ G SP+ Sbjct: 198 TAPESLAYNT-FSIKSDVWAFGVLLWEIATYGMSPY 232 >4TN6-A nrPDB Length = 318 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 57/227 (25%), Positives = 96/227 (42%), Gaps = 24/227 (10%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 N + + R IG G FG++Y G+ A+K L+ + K Q L + +I + Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQ---LHIESKIYKMMQGG 62 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAAEIILGLE 306 P I + D +++L+ DL S+ FS + A ++I +E Sbjct: 63 VGIPTI---RWCGAEGDYNVMVMELLGPSLEDLFNFCSRK--FSLKTVLLLADQMISRIE 117 Query: 307 HMHNRFVVYRDLKPANIL--LDEHGH-VRISDLGLACDFSKKKPHASV---------GTH 354 ++H++ ++RD+KP N L L + G+ V I D GLA + + H + GT Sbjct: 118 YIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTA 177 Query: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE 401 Y + G+ D SLG +L G P++ K K + Sbjct: 178 RYASINT-HLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQ 223 >2X7G-A nrPDB Length = 389 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/139 (30%), Positives = 60/139 (43%), Gaps = 12/139 (8%) Query: 331 VRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSP 390 V+I+DLG AC + K + T Y + EVL G Y + AD +S CM F+L G Sbjct: 227 VKIADLGNAC-WVHKHFTEDIQTRQYRSIEVL-IGAGYSTPADIWSTACMAFELATGDYL 284 Query: 391 FRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKES 450 F H +D + D + +EL S L G R+ R G L R ++K Sbjct: 285 FEPHSGED-YSRDEDHIAHIIELLGSIPRHFA--LSGKYSREFFNRRGEL-RHITKLKPW 340 Query: 451 PFFRSLDWQMVFLQKYPPP 469 F V ++KY P Sbjct: 341 SLFD------VLVEKYGWP 353 >1DK8-A nrPDB Length = 147 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 31/115 (26%), Positives = 54/115 (46%), Gaps = 6/115 (5%) Query: 64 GYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLE----TEEERLVCSREIFDTYIMKELLA 119 G LFR F LK E L++F+ + KLE EE+RL +R I+ YI+ Sbjct: 25 GISLFRTF-LKQ-EGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGI 82 Query: 120 CSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRF 174 S + ++G ++K+ + P +F EI + + + F++SD + + Sbjct: 83 VSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 137 >4WUA-A nrPDB Length = 401 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/83 (33%), Positives = 44/83 (53%), Gaps = 3/83 (3%) Query: 331 VRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSP 390 V+I+DLG AC + K + T Y + EVL G Y++ AD +S CM F+L G Sbjct: 239 VKIADLGNAC-WVHKHFTEDIQTRQYRSLEVL-IGSGYNTPADIWSTACMAFELATGDYL 296 Query: 391 FRQHKTKDKHEIDRMTLTMAVEL 413 F H + +++ D + + +EL Sbjct: 297 FEPH-SGEEYTRDEDHIALIIEL 318 >1EMU-A nrPDB Length = 132 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 31/115 (26%), Positives = 54/115 (46%), Gaps = 6/115 (5%) Query: 64 GYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLE----TEEERLVCSREIFDTYIMKELLA 119 G LFR F LK E L++F+ + KLE EE+RL +R I+ YI+ Sbjct: 19 GISLFRTF-LKQ-EGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGI 76 Query: 120 CSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRF 174 S + ++G ++K+ + P +F EI + + + F++SD + + Sbjct: 77 VSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 131 >4BTF-A nrPDB Length = 469 Score = 37.0 bits (84), Expect = 0.025, Method: Compositional matrix adjust. Identities = 37/199 (18%), Positives = 81/199 (40%), Gaps = 21/199 (10%) Query: 253 FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF 312 F +C+ P+ S +++ G L L + + + GL +H+ Sbjct: 260 FGICIDQTVKPPE-FSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSE 318 Query: 313 VVYRDLKPANILLDEHGHVRISDLGLA------CDFSKKKPHASVGTHGYMAPEVLQKGV 366 ++R++ ++ L+ V+++ L+ +K + Y++PE L+ Sbjct: 319 TLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPF 378 Query: 367 A-YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI---DRMTLTMAVELPD------- 415 YD A+ +S G +L+++ G PF +K E+ D+ + + P+ Sbjct: 379 CLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIIN 438 Query: 416 ---SFSPELRSLLEGLLQR 431 + P R ++G+L+R Sbjct: 439 ECRAHEPSQRPSVDGILER 457 >5FQD-C nrPDB Length = 341 Score = 37.0 bits (84), Expect = 0.029, Method: Compositional matrix adjust. Identities = 52/226 (23%), Positives = 92/226 (40%), Gaps = 26/226 (11%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG- 249 + + R IG G FG++Y G+ A+K L+ ++ + Q L E + ++ G Sbjct: 21 YKLVRKIGSGSFGDIYLAINITNGEEVAVK-LESQKARHPQ----LLYESKLYKILQGGV 75 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 P I + D ++DL+ DL S+ F+ + A ++I +E+ Sbjct: 76 GIPHI---RWYGQEKDYNVLVMDLLGPSLEDLFNFCSRR--FTMKTVLMLADQMISRIEY 130 Query: 308 MHNRFVVYRDLKPANILLDEHGHVR---ISDLGLACDFSKKKPHASV---------GTHG 355 +H + ++RD+KP N L+ H + D GLA + + + GT Sbjct: 131 VHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTAR 190 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE 401 Y + G+ D SLG +L R P++ K K + Sbjct: 191 YASINA-HLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQ 235 >4M69-B nrPDB Length = 283 Score = 36.6 bits (83), Expect = 0.037, Method: Compositional matrix adjust. Identities = 37/199 (18%), Positives = 81/199 (40%), Gaps = 21/199 (10%) Query: 253 FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF 312 F +C+ P+ S +++ G L L + + + GL +H+ Sbjct: 74 FGICIDQTVKPPE-FSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSE 132 Query: 313 VVYRDLKPANILLDEHGHVRISDLGLA------CDFSKKKPHASVGTHGYMAPEVLQKGV 366 ++R++ ++ L+ V+++ L+ +K + Y++PE L+ Sbjct: 133 TLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPF 192 Query: 367 A-YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI---DRMTLTMAVELPD------- 415 YD A+ +S G +L+++ G PF +K E+ D+ + + P+ Sbjct: 193 CLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIIN 252 Query: 416 ---SFSPELRSLLEGLLQR 431 + P R ++G+L+R Sbjct: 253 ECRAHEPSQRPSVDGILER 271 >3LMG-A nrPDB Length = 344 Score = 36.6 bits (83), Expect = 0.042, Method: Compositional matrix adjust. Identities = 32/131 (24%), Positives = 61/131 (46%), Gaps = 7/131 (5%) Query: 267 LSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL 325 L + + G L H+ QH G + + +I G+ ++ +V+R+L N+LL Sbjct: 107 LQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLL 166 Query: 326 DEHGHVRISDLGLACDF---SKKKPHASVGTH-GYMAPEVLQKGVAYDSSADWFSLGCML 381 V+++D G+A K+ ++ T +MA E + G Y +D +S G + Sbjct: 167 KSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFG-KYTHQSDVWSYGVTV 225 Query: 382 FKLLR-GHSPF 391 ++L+ G P+ Sbjct: 226 WELMTFGAEPY 236 >4IX6-A nrPDB Length = 350 Score = 33.1 bits (74), Expect = 0.37, Method: Compositional matrix adjust. Identities = 17/42 (40%), Positives = 27/42 (64%), Gaps = 2/42 (4%) Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEH--GHVRISDLGLA 339 E++ L +H VV+RD+KPAN++ E G +++ DLG A Sbjct: 151 ELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAA 192 >4CI6-B nrPDB Length = 643 Score = 33.1 bits (74), Expect = 0.42, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 43/95 (45%), Gaps = 4/95 (4%) Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDE-HGHVRISDLGLACDFSKKKPHASVG 352 ++F A ++ H+ +V+ D+KP N++ D G + DLGL S ++P Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSR-SGEQPKGF-- 214 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRG 387 T + APE+ + +D F + L + G Sbjct: 215 TESFKAPELGVGNLGASEKSDVFLVVSTLLHGIEG 249 >4L68-A nrPDB Length = 340 Score = 32.7 bits (73), Expect = 0.60, Method: Compositional matrix adjust. Identities = 35/124 (28%), Positives = 54/124 (43%), Gaps = 11/124 (8%) Query: 274 MNGGDLHYHLSQHGVFSEADMRFY----AAEIILGLEHMHNRFVVYRDLKPANILLDEHG 329 M+ G LH L + + RF AA + L H ++++++ + IL+DE Sbjct: 117 MSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDF 176 Query: 330 HVRISDLGLACDFSKKKPHAS------VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFK 383 RI D GLA + S +G GY+APE +A D + LG +L + Sbjct: 177 DARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLA-SLKGDVYGLGVVLLE 235 Query: 384 LLRG 387 L G Sbjct: 236 LATG 239 >4I94-A nrPDB Length = 300 Score = 32.3 bits (72), Expect = 0.64, Method: Compositional matrix adjust. Identities = 43/159 (27%), Positives = 64/159 (40%), Gaps = 26/159 (16%) Query: 313 VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSA 372 +Y DL +L D+ + R+S GL + K +++ + PE L+ G S Sbjct: 149 ALYHDLNAYRVLFDDDANPRLSCFGLMKNSRDGKSYST--NLAFTPPEYLRTGRVTPESV 206 Query: 373 DWFSLGCMLFKLLRG-HSPFRQHKTKDKHEID-----RMTLTMAVELPDSFSPELRSLLE 426 +S G +L LL G H P H +D + + M L FS + + L Sbjct: 207 -IYSFGTLLLDLLSGKHIP-------PSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELI 258 Query: 427 GLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQK 465 L R CL E +E P +SL M+ LQK Sbjct: 259 RLASR-------CL---QYEPRERPNPKSLVSAMIPLQK 287 >2RSV-A nrPDB Length = 403 Score = 32.3 bits (72), Expect = 0.66, Method: Compositional matrix adjust. Identities = 36/146 (24%), Positives = 61/146 (41%), Gaps = 15/146 (10%) Query: 260 AFHTPDKLSFILDLMN--GGDLH-YHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 H + S+ +M+ G DL + + FS + + I+ LE++H V+ Sbjct: 124 GLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHG 183 Query: 317 DLKPANILLDEHG--HVRISDLGLACDFSKKKPHASV---------GTHGYMAPEVLQKG 365 D+K +N+LL+ V + D GLA + + H GT + + + G Sbjct: 184 DIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDA-HNG 242 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPF 391 VA D LG + + L GH P+ Sbjct: 243 VAPSRRGDLEILGYCMIQWLTGHLPW 268 >2LAV-A nrPDB Length = 361 Score = 32.3 bits (72), Expect = 0.68, Method: Compositional matrix adjust. Identities = 30/114 (26%), Positives = 49/114 (42%), Gaps = 12/114 (10%) Query: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHG--HVRISDLGLACDFSKKK 346 FS + + I+ LE++H V+ D+K +N+LL+ V + D GLA + + Sbjct: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG 208 Query: 347 PHASV---------GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 H GT + + + GVA D LG + + L GH P+ Sbjct: 209 VHKEYKEDPKRCHDGTIEFTSIDA-HNGVAPSRRGDLEILGYCMIQWLTGHLPW 261 >5DMZ-A nrPDB Length = 365 Score = 32.0 bits (71), Expect = 0.99, Method: Compositional matrix adjust. Identities = 46/217 (21%), Positives = 86/217 (39%), Gaps = 32/217 (14%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 VH ++G G F +VY + D + K K + ++M L + Sbjct: 69 VHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHM 128 Query: 253 FIVCMSYAFHTPDKLSFIL-------DLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 F+ Y+ H S ++ L+N +L Y + V + + +A ++ + Sbjct: 129 FM--KFYSAHLFQNGSVLVGELYSYGTLLNAINL-YKNTPEKVMPQGLVISFAMRMLYMI 185 Query: 306 EHMHNRFVVYRDLKPANILL-----------DEHGHVRISDLGLACDFSKKKPHASV--- 351 E +H+ +++ D+KP N +L D + + DLG + D K P ++ Sbjct: 186 EQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDM-KLFPKGTIFTA 244 Query: 352 --GTHGYMAPEVLQKGVAYDSSADWFSLG----CMLF 382 T G+ E+L ++ D+F + CMLF Sbjct: 245 KCETSGFQCVEMLSNK-PWNYQIDYFGVAATVYCMLF 280 >1CSN-A nrPDB Length = 298 Score = 30.8 bits (68), Expect = 2.2, Method: Compositional matrix adjust. Identities = 31/133 (23%), Positives = 58/133 (43%), Gaps = 18/133 (13%) Query: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-----EHGHVRISDLGLACDFS 343 FS + A +++ ++ +H + +VYRD+KP N L+ + + D G+ + Sbjct: 103 FSVKTVAMAAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYR 162 Query: 344 ----------KKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQ 393 ++K + S GT YM+ G D +LG + LRG P++ Sbjct: 163 DPVTKQHIPYREKKNLS-GTARYMSINT-HLGREQSRRDDLEALGHVFMYFLRGSLPWQG 220 Query: 394 HK-TKDKHEIDRM 405 K +K + +R+ Sbjct: 221 LKAATNKQKYERI 233 >2EBZ-A nrPDB Length = 155 Score = 30.8 bits (68), Expect = 2.3, Method: Compositional matrix adjust. Identities = 30/123 (24%), Positives = 54/123 (43%), Gaps = 18/123 (14%) Query: 53 VTFEKIFSQKLGYLLFRDFCLKHLEEAKPL----VEFYEEIKKYEKLETEEERLVCSREI 108 V+FE++ +G F DF K E L E++ + ++K E +REI Sbjct: 17 VSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYR----AREI 72 Query: 109 FDTYIMKELLACSHPFSKSAIEHVQGHL---VKKQVPPDLFQPYIEEICQNLRGDVFQKF 165 F ++ CS + I+ Q L V + PD+F+ +I ++ D + +F Sbjct: 73 FSKFL------CSKATTPVNIDS-QAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRF 125 Query: 166 IES 168 ++S Sbjct: 126 LKS 128 >3AB0-B nrPDB Length = 117 Score = 29.6 bits (65), Expect = 4.5, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 21/37 (56%), Gaps = 1/37 (2%) Query: 257 MSYAFHTPDK-LSFILDLMNGGDLHYHLSQHGVFSEA 292 MS+ TP+K L ++ + GGD HY S G F+ + Sbjct: 34 MSWVRQTPEKRLEWVASISTGGDTHYQDSVKGRFTTS 70 >6BII-A nrPDB Length = 333 Score = 29.6 bits (65), Expect = 5.0, Method: Compositional matrix adjust. Identities = 31/133 (23%), Positives = 53/133 (39%), Gaps = 4/133 (3%) Query: 104 CSREIFDTYIMKELLAC-SHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVF 162 RE+FD ++A + + IE + PD+ ++ L Sbjct: 57 IDREVFDAAPRLRIVANYAVGYDNIDIEEATKRGIYVTNTPDVLTDATADLAWALLLAAA 116 Query: 163 QKFIESDKFTRFCQWKNVELNIHLTMN-DFSVH-RIIGRGGFGEVYGCRKADTGKMYAMK 220 + ++ DKF R +WK + H M + V+ + IG GFG + G A K + M+ Sbjct: 117 RHVVKGDKFVRSGEWKRRGIAWHPKMFLGYDVYGKTIGIVGFGRI-GQAIAKRAKGFGMR 175 Query: 221 CLDKKRIKMKQGE 233 L R + + E Sbjct: 176 ILYTARSRKPEAE 188 >4B68-A nrPDB Length = 501 Score = 29.3 bits (64), Expect = 5.5, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 25/50 (50%), Gaps = 3/50 (6%) Query: 564 YMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQ 613 Y+ ++ NP TQWQ R + P R R E PQS + + S E++ Sbjct: 340 YLQRVKNPDETQWQHR---ILPERKITRVEHHGPQSRMRIHLKSSKPESE 386 >1I1G-A nrPDB Length = 141 Score = 29.3 bits (64), Expect = 6.5, Method: Composition-based stats. Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 9/84 (10%) Query: 14 LMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRG--EVTFEKIFSQKLGYLLFRDF 71 L +EK TP +KK+ + E ++R + K LE++G E KI +KLGY L Sbjct: 10 LEILEKDARTPFTEIAKKLGISETAVRKRV-KALEEKGIIEGYTIKINPKKLGYSLVTIT 68 Query: 72 CLKHLEEAKP--LVEFYEEIKKYE 93 + + KP L E E++K+Y+ Sbjct: 69 GV----DTKPEKLFEVAEKLKEYD 88 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3PVW-A nrPDB 1105 0.0 5UUU-A nrPDB 768 0.0 4YHJ-A nrPDB 536 e-152 3NYO-A nrPDB 534 e-152 3C51-A nrPDB 510 e-144 4TNB-A nrPDB 509 e-144 2JDO-A nrPDB 352 2e-97 3MV5-A nrPDB 352 4e-97 5KCV-A nrPDB 347 8e-96 5N23-A nrPDB 346 2e-95 1FOT-A nrPDB 346 3e-95 4L42-A nrPDB 341 4e-94 4WB7-A nrPDB 340 1e-93 3TXO-A nrPDB 340 1e-93 5D9K-A nrPDB 340 1e-93 2Z7Q-A nrPDB 338 6e-93 5X3F-B nrPDB 338 7e-93 4RA4-A nrPDB 336 2e-92 6E9W-A nrPDB 336 3e-92 3PFQ-A nrPDB 335 5e-92 1VZO-A nrPDB 335 6e-92 2I0E-A nrPDB 333 2e-91 3HDN-A nrPDB 331 4e-91 5F9E-A nrPDB 331 7e-91 5FET-A nrPDB 326 3e-89 3A8W-A nrPDB 325 3e-89 4RLP-A nrPDB 323 1e-88 5DYK-A nrPDB 318 5e-87 6ED6-A nrPDB 315 4e-86 4OTD-A nrPDB 308 6e-84 6BDL-A nrPDB 306 2e-83 3TKU-A nrPDB 304 1e-82 4CRS-A nrPDB 300 1e-81 4AW2-A nrPDB 296 2e-80 4FR4-A nrPDB 293 2e-79 5JN2-A nrPDB 292 3e-79 3ZUT-A nrPDB 291 8e-79 3ORZ-A nrPDB 290 1e-78 4CFF-A nrPDB 289 4e-78 2QNJ-A nrPDB 288 5e-78 4REW-A nrPDB 288 6e-78 3MA6-A nrPDB 288 7e-78 5EZV-A nrPDB 287 9e-78 3UDB-A nrPDB 287 1e-77 5KZ7-A nrPDB 287 1e-77 2VD5-A nrPDB 286 2e-77 5ES1-A nrPDB 286 2e-77 4RED-A nrPDB 286 2e-77 3MN3-A nrPDB 286 3e-77 5FG8-A nrPDB 286 3e-77 5WAX-A nrPDB 285 3e-77 4YZB-A nrPDB 284 7e-77 2YZA-A nrPDB 284 8e-77 4CFH-A nrPDB 283 1e-76 2BDW-A nrPDB 283 3e-76 5LOH-A nrPDB 282 3e-76 5IG1-A nrPDB 282 4e-76 4FG9-A nrPDB 282 4e-76 3H4J-B nrPDB 282 4e-76 2JC6-A nrPDB 281 6e-76 3DXN-A nrPDB 281 7e-76 3UC3-A nrPDB 281 8e-76 3KK8-A nrPDB 281 8e-76 2VN9-A nrPDB 281 9e-76 4D28-A nrPDB 281 9e-76 3HZT-A nrPDB 280 1e-75 3DFA-A nrPDB 279 2e-75 4MVF-A nrPDB 279 2e-75 5U6Y-A nrPDB 279 2e-75 3NCG-A nrPDB 279 2e-75 2V7O-A nrPDB 278 5e-75 3D2K-A nrPDB 278 6e-75 2VZ6-A nrPDB 278 6e-75 3BHH-A nrPDB 277 1e-74 4CZT-A nrPDB 276 2e-74 3LIJ-A nrPDB 275 4e-74 2JAM-A nrPDB 275 4e-74 4JXF-A nrPDB 275 5e-74 5YKS-A nrPDB 274 8e-74 4UZD-A nrPDB 274 8e-74 6C9D-A nrPDB 273 1e-73 4RGJ-A nrPDB 273 2e-73 2HAK-A nrPDB 273 2e-73 6BXI-A nrPDB 272 3e-73 3SOA-A nrPDB 272 4e-73 3Q5I-A nrPDB 272 5e-73 5JZN-A nrPDB 268 6e-72 4YNZ-A nrPDB 267 1e-71 2J90-A nrPDB 266 2e-71 4CQG-A nrPDB 266 2e-71 4B8L-A nrPDB 266 3e-71 4NIF-A nrPDB 266 3e-71 3GUB-A nrPDB 265 5e-71 4D2V-A nrPDB 264 9e-71 2YAB-A nrPDB 263 1e-70 2YCR-A nrPDB 263 2e-70 3COM-A nrPDB 263 2e-70 3TAC-A nrPDB 262 4e-70 2BPM-A nrPDB 262 5e-70 2Y7J-A nrPDB 261 5e-70 6FDY-U nrPDB 261 6e-70 4C0T-A nrPDB 261 6e-70 4JG6-A nrPDB 261 7e-70 3I6U-A nrPDB 261 1e-69 1PHK-A nrPDB 260 1e-69 2W4O-A nrPDB 260 2e-69 6FD3-A nrPDB 259 2e-69 4LG4-A nrPDB 259 4e-69 1ZWS-A nrPDB 258 5e-69 2A27-A nrPDB 258 5e-69 5XZW-A nrPDB 258 5e-69 4AF3-A nrPDB 258 6e-69 3F3Z-A nrPDB 254 1e-67 6AO5-A nrPDB 253 2e-67 4AGU-A nrPDB 253 2e-67 3NIZ-A nrPDB 253 2e-67 4I6B-A nrPDB 253 2e-67 3DB8-A nrPDB 251 7e-67 4QMW-A nrPDB 251 8e-67 4PDS-A nrPDB 251 9e-67 3DAK-A nrPDB 251 1e-66 4B6L-A nrPDB 251 1e-66 2F57-A nrPDB 251 1e-66 3Q53-A nrPDB 250 1e-66 6CMJ-A nrPDB 250 1e-66 3KN6-A nrPDB 250 1e-66 4CSV-A nrPDB 249 4e-66 4KS7-A nrPDB 248 5e-66 2UV2-A nrPDB 247 8e-66 3IS5-A nrPDB 247 1e-65 2HW6-A nrPDB 247 1e-65 2Q0N-A nrPDB 246 2e-65 4JDH-A nrPDB 246 2e-65 2WQN-A nrPDB 246 3e-65 5YV8-A nrPDB 246 3e-65 4XBR-A nrPDB 246 4e-65 2OU7-A nrPDB 246 4e-65 2XIK-A nrPDB 245 4e-65 4FZF-B nrPDB 245 5e-65 4FIE-A nrPDB 245 5e-65 4J52-A nrPDB 245 6e-65 3UTO-A nrPDB 245 6e-65 3FXW-A nrPDB 244 1e-64 6QAU-A nrPDB 244 1e-64 5D7A-A nrPDB 243 2e-64 5J5T-A nrPDB 243 2e-64 6GU6-A nrPDB 243 2e-64 6HXF-B nrPDB 242 3e-64 1KOA-A nrPDB 242 3e-64 4WNO-A nrPDB 242 4e-64 1KOB-A nrPDB 241 7e-64 3V5Q-A nrPDB 240 1e-63 4KRC-A nrPDB 240 1e-63 4MYG-A nrPDB 240 2e-63 2X4F-A nrPDB 239 2e-63 6CKI-A nrPDB 239 2e-63 3KA0-A nrPDB 239 4e-63 1NY3-A nrPDB 239 4e-63 2OZA-A nrPDB 238 5e-63 5DBX-A nrPDB 237 8e-63 4APC-A nrPDB 237 1e-62 4EWQ-A nrPDB 237 2e-62 4AT3-A nrPDB 236 2e-62 6E2O-A nrPDB 236 2e-62 3LM0-A nrPDB 236 3e-62 4P5Q-A nrPDB 234 8e-62 1CM8-A nrPDB 234 8e-62 4AN9-A nrPDB 234 1e-61 1V0B-A nrPDB 234 1e-61 4BBM-A nrPDB 234 1e-61 3DKO-A nrPDB 233 2e-61 2BRG-A nrPDB 232 3e-61 1JPA-A nrPDB 232 5e-61 4AU8-A nrPDB 231 6e-61 6DTL-A nrPDB 231 6e-61 3PPZ-A nrPDB 231 7e-61 4X7Q-B nrPDB 231 1e-60 3OHT-A nrPDB 230 2e-60 5KMM-A nrPDB 230 2e-60 4GS6-A nrPDB 230 2e-60 5MJB-A nrPDB 230 2e-60 3VN9-A nrPDB 229 2e-60 4XEY-B nrPDB 229 3e-60 2F9G-A nrPDB 229 3e-60 2Y6O-A nrPDB 229 4e-60 4IC8-A nrPDB 228 6e-60 4BGQ-A nrPDB 228 7e-60 4UY9-A nrPDB 227 9e-60 3FME-A nrPDB 227 1e-59 4ZSG-A nrPDB 227 1e-59 4EBW-A nrPDB 227 1e-59 2VWV-A nrPDB 227 1e-59 3DTC-A nrPDB 227 2e-59 2XYN-A nrPDB 227 2e-59 5G6V-A nrPDB 226 2e-59 2R2P-A nrPDB 226 2e-59 6NPU-A nrPDB 226 4e-59 4U41-A nrPDB 225 4e-59 1G3N-A nrPDB 225 5e-59 3ZDU-A nrPDB 225 5e-59 5H2U-A nrPDB 225 6e-59 5L6P-A nrPDB 224 7e-59 6CCF-A nrPDB 223 2e-58 4UYA-A nrPDB 223 2e-58 3HKO-A nrPDB 223 2e-58 5X02-A nrPDB 223 2e-58 3CJF-A nrPDB 222 3e-58 5KKR-C nrPDB 222 4e-58 5EFQ-A nrPDB 222 4e-58 3OZ6-A nrPDB 222 4e-58 1UA2-A nrPDB 222 4e-58 2J0K-A nrPDB 222 5e-58 3GC0-A nrPDB 222 5e-58 5Z33-A nrPDB 221 1e-57 4H1J-A nrPDB 221 1e-57 3EQC-A nrPDB 221 1e-57 1U5R-A nrPDB 220 2e-57 4E93-A nrPDB 220 2e-57 6GQK-A nrPDB 219 2e-57 4NST-A nrPDB 219 2e-57 2GCD-A nrPDB 219 4e-57 5X5O-A nrPDB 219 4e-57 4QNY-A nrPDB 219 4e-57 4O2Z-A nrPDB 219 4e-57 4XUF-A nrPDB 218 6e-57 6CQF-A nrPDB 218 6e-57 3BGP-A nrPDB 217 1e-56 4XLV-A nrPDB 217 1e-56 1K9A-A nrPDB 217 1e-56 3GC9-A nrPDB 217 1e-56 5TUR-A nrPDB 216 2e-56 3ALO-A nrPDB 216 2e-56 5NGU-A nrPDB 216 3e-56 2XNP-A nrPDB 216 3e-56 3KUL-B nrPDB 216 4e-56 5AIR-A nrPDB 216 4e-56 1BYG-A nrPDB 216 4e-56 4RC3-A nrPDB 216 4e-56 4PDO-A nrPDB 215 5e-56 2H8H-A nrPDB 215 6e-56 3ZBF-A nrPDB 215 6e-56 6DBM-A nrPDB 215 7e-56 5AWM-A nrPDB 214 7e-56 3M42-A nrPDB 214 7e-56 4EQM-A nrPDB 214 9e-56 2W96-B nrPDB 214 1e-55 1FVR-A nrPDB 213 2e-55 1S9I-A nrPDB 213 2e-55 6F3F-A nrPDB 213 2e-55 3SXS-A nrPDB 213 2e-55 5GRN-A nrPDB 213 2e-55 3TT0-A nrPDB 213 3e-55 2OGV-A nrPDB 212 3e-55 4QTB-A nrPDB 212 3e-55 4OLI-A nrPDB 212 3e-55 3PG1-A nrPDB 212 4e-55 3E7O-A nrPDB 212 4e-55 3DLS-A nrPDB 212 5e-55 2XS0-A nrPDB 212 6e-55 5B2L-A nrPDB 211 6e-55 3MIA-A nrPDB 211 7e-55 3BEA-A nrPDB 211 8e-55 5VO2-A nrPDB 211 1e-54 4E20-A nrPDB 211 1e-54 4XCU-A nrPDB 211 1e-54 5A46-A nrPDB 211 1e-54 1LUF-A nrPDB 211 1e-54 5AMN-A nrPDB 211 1e-54 3GQL-A nrPDB 211 1e-54 3A4O-X nrPDB 211 1e-54 4HZS-A nrPDB 211 1e-54 3KRL-A nrPDB 210 1e-54 1JNK-A nrPDB 210 2e-54 5HI2-A nrPDB 210 2e-54 2DQ7-X nrPDB 210 2e-54 5O2C-A nrPDB 210 2e-54 5O2B-A nrPDB 209 3e-54 1U54-B nrPDB 209 3e-54 3ORP-A nrPDB 209 3e-54 3E3P-A nrPDB 209 3e-54 3QGY-A nrPDB 209 3e-54 4R7H-A nrPDB 209 4e-54 5SYS-A nrPDB 209 4e-54 6FEX-A nrPDB 209 5e-54 4Y83-A nrPDB 208 5e-54 3IO7-A nrPDB 208 6e-54 6BSD-A nrPDB 208 6e-54 4E7W-A nrPDB 207 9e-54 2W1I-A nrPDB 207 1e-53 6GVJ-A nrPDB 207 1e-53 3G0E-A nrPDB 207 1e-53 2PL0-A nrPDB 207 1e-53 3FI2-A nrPDB 207 1e-53 4YFF-A nrPDB 207 1e-53 2WTK-C nrPDB 207 2e-53 5HIE-A nrPDB 206 3e-53 3HMP-A nrPDB 206 3e-53 3I81-A nrPDB 205 4e-53 1U59-A nrPDB 205 4e-53 1TKI-A nrPDB 205 4e-53 2HK5-A nrPDB 205 5e-53 5FM2-A nrPDB 205 5e-53 5AP3-A nrPDB 204 9e-53 5Y86-A nrPDB 204 1e-52 3OMV-A nrPDB 204 1e-52 2PSQ-A nrPDB 204 1e-52 1ZXE-A nrPDB 204 1e-52 4PWN-A nrPDB 203 2e-52 2ZMD-A nrPDB 203 2e-52 2OZO-A nrPDB 203 2e-52 3N9X-A nrPDB 203 2e-52 3BBT-B nrPDB 202 3e-52 3QUP-A nrPDB 202 4e-52 4IDT-A nrPDB 202 4e-52 4K33-A nrPDB 202 4e-52 6O6Q-A nrPDB 202 5e-52 6E4F-A nrPDB 202 6e-52 4HVI-A nrPDB 201 7e-52 3LZB-A nrPDB 201 7e-52 5GNK-A nrPDB 201 9e-52 4LRM-A nrPDB 200 1e-51 4XI2-A nrPDB 200 1e-51 3AOX-A nrPDB 200 1e-51 3NIE-A nrPDB 200 2e-51 4Y93-A nrPDB 199 3e-51 4MD7-E nrPDB 199 4e-51 3PP0-A nrPDB 198 6e-51 5EG3-A nrPDB 198 7e-51 1AD5-A nrPDB 197 1e-50 6FER-A nrPDB 197 1e-50 4LQP-A nrPDB 197 1e-50 4F0G-A nrPDB 197 2e-50 5O0Y-A nrPDB 197 2e-50 6DBN-A nrPDB 197 2e-50 2I6L-A nrPDB 196 2e-50 3PLS-A nrPDB 196 3e-50 5HVK-A nrPDB 196 3e-50 3ZZW-A nrPDB 195 6e-50 5HLW-A nrPDB 195 6e-50 4FL3-A nrPDB 194 8e-50 3RP9-A nrPDB 194 9e-50 6EII-A nrPDB 194 1e-49 5ZTN-A nrPDB 193 2e-49 4TPT-A nrPDB 193 3e-49 4NEU-A nrPDB 193 3e-49 5XVU-A nrPDB 192 4e-49 6HMD-A nrPDB 192 4e-49 3EB0-A nrPDB 192 4e-49 5C26-A nrPDB 192 4e-49 2PVN-A nrPDB 192 6e-49 5VD3-A nrPDB 191 6e-49 3C1X-A nrPDB 191 8e-49 4G3E-A nrPDB 191 9e-49 5U6B-A nrPDB 190 1e-48 6CTH-A nrPDB 188 6e-48 4C59-A nrPDB 188 6e-48 5X8I-B nrPDB 187 1e-47 4M7I-A nrPDB 187 1e-47 3UIM-A nrPDB 186 3e-47 4KIK-B nrPDB 186 3e-47 5LPZ-A nrPDB 186 3e-47 5LPV-A nrPDB 185 4e-47 6B2Q-A nrPDB 185 5e-47 2WO6-A nrPDB 185 5e-47 4OW8-A nrPDB 185 5e-47 3QA8-A nrPDB 185 5e-47 4X3F-A nrPDB 185 5e-47 5VC6-A nrPDB 183 2e-46 2A1A-B nrPDB 182 4e-46 5U6C-A nrPDB 182 5e-46 4LFI-A nrPDB 181 7e-46 5WNO-A nrPDB 181 9e-46 5TOS-A nrPDB 181 9e-46 6FYV-A nrPDB 181 1e-45 5VDK-A nrPDB 181 1e-45 6J5U-C nrPDB 181 1e-45 3HNG-A nrPDB 180 1e-45 5WNL-A nrPDB 180 1e-45 5TQX-A nrPDB 180 2e-45 3LLT-A nrPDB 179 4e-45 5UIU-A nrPDB 178 9e-45 3Q4U-A nrPDB 178 9e-45 5UNP-A nrPDB 177 1e-44 3UIU-A nrPDB 177 1e-44 2PMN-X nrPDB 176 2e-44 3RAW-A nrPDB 175 5e-44 2QKW-B nrPDB 174 9e-44 2H34-A nrPDB 174 1e-43 2RIO-A nrPDB 170 1e-42 3MDY-A nrPDB 170 2e-42 2BUJ-A nrPDB 170 3e-42 2WTK-B nrPDB 169 3e-42 3MY0-A nrPDB 169 4e-42 5TE0-A nrPDB 168 8e-42 6HV0-A nrPDB 166 2e-41 4CRL-A nrPDB 166 3e-41 3VHK-A nrPDB 165 6e-41 4PL5-B nrPDB 165 7e-41 3SV0-A nrPDB 164 1e-40 4JLC-A nrPDB 164 2e-40 5XD6-A nrPDB 164 2e-40 2Y4I-B nrPDB 164 2e-40 6DC0-A nrPDB 163 2e-40 1PY5-A nrPDB 163 2e-40 4EUU-A nrPDB 163 3e-40 5CEK-A nrPDB 163 3e-40 4EUT-A nrPDB 162 5e-40 4TN6-A nrPDB 161 9e-40 5AR8-A nrPDB 161 1e-39 4M66-A nrPDB 160 2e-39 5IKW-A nrPDB 159 3e-39 4IAN-A nrPDB 159 3e-39 2JD5-A nrPDB 159 4e-39 6NT9-A nrPDB 159 5e-39 6O8B-A nrPDB 158 6e-39 3QD2-B nrPDB 157 1e-38 5E8V-A nrPDB 155 6e-38 2C47-A nrPDB 155 7e-38 5L2Q-C nrPDB 154 1e-37 2CMW-A nrPDB 154 1e-37 3G2F-A nrPDB 153 2e-37 2CHL-A nrPDB 153 2e-37 4RT7-A nrPDB 153 3e-37 6BFN-A nrPDB 153 3e-37 3SOC-A nrPDB 151 8e-37 4BTK-A nrPDB 150 2e-36 4NFN-A nrPDB 150 3e-36 4F9B-A nrPDB 148 7e-36 2X7G-A nrPDB 148 8e-36 4NT4-A nrPDB 148 1e-35 2QLU-A nrPDB 147 2e-35 5X18-A nrPDB 145 8e-35 4XHH-A nrPDB 144 1e-34 4XHL-A nrPDB 142 4e-34 5M07-A nrPDB 139 3e-33 5CLR-A nrPDB 137 1e-32 4JRN-A nrPDB 133 3e-31 5OAT-A nrPDB 131 9e-31 2PZI-A nrPDB 127 2e-29 4Y12-A nrPDB 126 3e-29 5UU1-A nrPDB 124 1e-28 6EQI-C nrPDB 123 3e-28 6J6I-B nrPDB 113 2e-25 Sequences not found previously or not previously below threshold: 2FO0-A nrPDB 226 2e-59 3LMG-A nrPDB 177 2e-44 5FQD-C nrPDB 156 3e-38 4WUA-A nrPDB 141 8e-34 1CSN-A nrPDB 138 6e-33 4MWI-A nrPDB 123 2e-28 4M69-B nrPDB 123 2e-28 3REP-A nrPDB 122 5e-28 4BTF-A nrPDB 122 6e-28 4L00-A nrPDB 122 7e-28 5J0A-A nrPDB 122 7e-28 5USZ-A nrPDB 122 8e-28 5X1R-A nrPDB 119 3e-27 5C01-A nrPDB 116 4e-26 4WOV-A nrPDB 115 6e-26 4I94-A nrPDB 104 1e-22 5UV4-A nrPDB 101 1e-21 4L68-A nrPDB 98 1e-20 2RSV-A nrPDB 97 3e-20 2LAV-A nrPDB 97 3e-20 4O1O-A nrPDB 85 1e-16 2JII-A nrPDB 77 3e-14 4OAU-C nrPDB 76 7e-14 4IX6-A nrPDB 73 3e-13 4CI6-B nrPDB 71 2e-12 6G4J-A nrPDB 70 2e-12 5DMZ-A nrPDB 68 9e-12 6EWX-A nrPDB 68 2e-11 6BHC-A nrPDB 66 5e-11 6M7Z-A nrPDB 66 6e-11 6EAS-A nrPDB 64 2e-10 4AZW-A nrPDB 56 5e-08 3BYV-A nrPDB 56 6e-08 4CYJ-A nrPDB 56 7e-08 4AZV-A nrPDB 55 8e-08 5GZA-A nrPDB 55 2e-07 3ENH-A nrPDB 52 7e-07 4WWA-A nrPDB 52 1e-06 3DZO-A nrPDB 51 1e-06 5VE6-A nrPDB 50 4e-06 2W1Z-A nrPDB 50 4e-06 3Q60-A nrPDB 49 6e-06 4CZY-B nrPDB 48 9e-06 6G38-A nrPDB 46 5e-05 5GZ9-A nrPDB 46 6e-05 2EBZ-A nrPDB 45 2e-04 1TQM-A nrPDB 43 3e-04 2JNU-A nrPDB 42 0.001 1DK8-A nrPDB 42 0.001 1EMU-A nrPDB 41 0.002 4OTP-A nrPDB 41 0.002 6G5I-z nrPDB 40 0.003 5YK0-A nrPDB 39 0.009 1EZY-A nrPDB 38 0.018 1AGR-E nrPDB 38 0.020 6FDN-A nrPDB 37 0.039 6G18-v nrPDB 36 0.049 >3PVW-A nrPDB Length = 695 Score = 1105 bits (2859), Expect = 0.0, Method: Composition-based stats. Identities = 688/689 (99%), Positives = 689/689 (100%) Query: 1 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS 60 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS Sbjct: 1 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS 60 Query: 61 QKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLAC 120 QKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLAC Sbjct: 61 QKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLAC 120 Query: 121 SHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV 180 SHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV Sbjct: 121 SHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV 180 Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER Sbjct: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE Sbjct: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE 360 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE Sbjct: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE 360 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE Sbjct: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA Sbjct: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480 Query: 481 DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK 540 DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK Sbjct: 481 DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK 540 Query: 541 KTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL 600 KTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL Sbjct: 541 KTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL 600 Query: 601 LTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQR 660 LTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQR Sbjct: 601 LTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQR 660 Query: 661 VPKMKNKPRSPVVELSKVPLIQRGSANGL 689 VPKMKNKPR+PVVELSKVPLIQRGSANGL Sbjct: 661 VPKMKNKPRAPVVELSKVPLIQRGSANGL 689 >5UUU-A nrPDB Length = 547 Score = 768 bits (1984), Expect = 0.0, Method: Composition-based stats. Identities = 511/529 (96%), Positives = 518/529 (97%) Query: 10 DVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFR 69 ++ + AME +TPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFR Sbjct: 19 NLYFQGAMEPGGSTPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFR 78 Query: 70 DFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAI 129 DFCL HLEEA+PLVEFYEEIKKYEKLETEEER+ SREIFD+YIMKELLACSHPFSKSA Sbjct: 79 DFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSAT 138 Query: 130 EHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMN 189 EHVQGHL KKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMN Sbjct: 139 EHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMN 198 Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG Sbjct: 199 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 258 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH Sbjct: 259 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 318 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYD 369 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYD Sbjct: 319 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYD 378 Query: 370 SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLL 429 SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLL Sbjct: 379 SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLL 438 Query: 430 QRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFD 489 QRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFD Sbjct: 439 QRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFD 498 Query: 490 EEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEA 538 EEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEA Sbjct: 499 EEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEA 547 >4YHJ-A nrPDB Length = 584 Score = 536 bits (1380), Expect = e-152, Method: Composition-based stats. Identities = 192/537 (35%), Positives = 290/537 (54%), Gaps = 21/537 (3%) Query: 3 DLEAVLADVSYLMAMEKSKATPAARASKK---ILLPEPSIRSVMQKYLEDRGEVTFEKIF 59 +LE ++A+ L A + + R+ K + LP S S ++ +E +K Sbjct: 2 ELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDK-- 59 Query: 60 SQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLA 119 Q +G LFR FC + +EF + + +YE + +E+R C I D + +L A Sbjct: 60 -QPIGRRLFRQFCDTKPTLKR-HIEFLDAVAEYE-VADDEDRSDCGLSILDRFFNDKLAA 116 Query: 120 CSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKN 179 + + L ++ F+ LRG+ F+++ ES F++F QWK Sbjct: 117 PLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKW 176 Query: 180 VELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 239 +E +T N F +R++G+GGFGEV C+ TGKMYA K L KKRIK ++GE +ALNE Sbjct: 177 LERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNE 235 Query: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFY 297 + +L V + F+V ++YA+ T D L +L +MNGGDL +H+ G F E FY Sbjct: 236 KRILEKVQS---RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFY 292 Query: 298 AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-HASVGTHGY 356 AAE+ GLE + +VYRDLKP NILLD+ GH+RISDLGLA + + + VGT GY Sbjct: 293 AAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGY 352 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK-DKHEIDRMTLTMAVELPD 415 MAPEV+ Y S DW+ LGC+++++++GHSPF+++K K E+D+ E + Sbjct: 353 MAPEVVN-NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSE 411 Query: 416 SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRG 475 FS + +S+ LL ++ ++RLGC G GA VK+ P F+ ++++ + PP P Sbjct: 412 KFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPH 471 Query: 476 EVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTIN 530 V D DI F KGI L +D++ Y F +S WQ E+ E+ F IN Sbjct: 472 AVYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDIN 526 >3NYO-A nrPDB Length = 576 Score = 534 bits (1376), Expect = e-152, Method: Composition-based stats. Identities = 202/538 (37%), Positives = 294/538 (54%), Gaps = 22/538 (4%) Query: 3 DLEAVLADVSYLMAMEKSKATPAARASKK---ILLPEPSIRSVMQKYLEDRGEVTFEKIF 59 +LE ++A+ L A E ++ K + P S ++ LE E+ Sbjct: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCER-- 59 Query: 60 SQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLA 119 Q +G LLFR+FC E ++ V F + + +YE + +++R C R++ ++ Sbjct: 60 -QPIGRLLFREFCATRPELSR-CVAFLDGVAEYE-VTPDDKRKACGRQLTQNFLSHTGPD 116 Query: 120 CSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKN 179 + + + L + DLFQ + L F +++S F RF QWK Sbjct: 117 LIPEVPRQLVTNCTQRLEQGPC-KDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKW 175 Query: 180 VELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 239 +E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE +ALNE Sbjct: 176 LERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNE 234 Query: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFY 297 + +L V + F+V ++YA+ T D L +L LMNGGDL +H+ G F EA FY Sbjct: 235 KQILEKV---NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 Query: 298 AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-HASVGTHGY 356 AAEI GLE +H +VYRDLKP NILLD+HGH+RISDLGLA + + VGT GY Sbjct: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGY 351 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPD 415 MAPEV+ K Y S DW++LGC+L++++ G SPF+Q K K K E++R+ + E + Sbjct: 352 MAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 Query: 416 SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRG 475 FSP+ RSL LL +D RLGC G A+EVKE P F+ L+++ + PP P Sbjct: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQ 470 Query: 476 EVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTINA 531 + D DI F KG++L +DQ+ Y+ F ++ WQ E+ ET F +N Sbjct: 471 AIYCKDVLDIEQFS--TVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNV 526 >3C51-A nrPDB Length = 543 Score = 510 bits (1313), Expect = e-144, Method: Composition-based stats. Identities = 187/547 (34%), Positives = 293/547 (53%), Gaps = 35/547 (6%) Query: 1 MADLEAVLADVSYLMAMEKSKAT--PAARASK---KILLPEPSIRSVMQKYLEDRGEVTF 55 LE V+A+ +++ A A+ PA+R K ++ LP S +++ L+ + F Sbjct: 3 FGSLETVVANSAFIAARGSFDASSGPASRDRKYLARLKLPPLSKCEALRESLD----LGF 58 Query: 56 EKI-FSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIM 114 E + Q +G LF+ F H E+ P ++ +++I+ Y+ + + R ++ + Y+ Sbjct: 59 EGMCLEQPIGKRLFQQFLRTH-EQHGPALQLWKDIEDYDTAD-DALRPQKAQALRAAYLE 116 Query: 115 KEL-LACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTR 173 + L CS +++ G LFQP + + +L FQ+F++S F R Sbjct: 117 PQAQLFCSFLDAETVARARAG------AGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLR 170 Query: 174 FCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE 233 F QWK +E + + F R++GRGGFGEV+ C+ TGK+YA K L+KKR+K ++G Sbjct: 171 FLQWKWLEAQ-PMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGY 229 Query: 234 TLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL----SQHGVF 289 A+ E+ +L+ V + FIV ++YAF T L ++ +MNGGD+ YH+ + F Sbjct: 230 QGAMVEKKILAKVHS---RFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGF 286 Query: 290 SEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKP 347 E FY A+I+ GLEH+H R ++YRDLKP N+LLD+ G+VRISDLGLA + + K Sbjct: 287 QEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKT 346 Query: 348 HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK-DKHEIDRMT 406 GT G+MAPE+L G YD S D+F+LG L++++ PFR K + E+ + Sbjct: 347 KGYAGTPGFMAPELLL-GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRV 405 Query: 407 LTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKY 466 L AV PD FSP + E LLQ+D +RLG ++ P FR + W+ + Sbjct: 406 LEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGML 465 Query: 467 PPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET- 524 PP +P V A + D+G+F KG+ +D E ++ F T WQ+E+ ET Sbjct: 466 TPPFVPDSRTVYAKNIQDVGAFS--TVKGVAFEKADTEFFQEFASGTCPIPWQEEMIETG 523 Query: 525 VFDTINA 531 VF +N Sbjct: 524 VFGDLNV 530 >4TNB-A nrPDB Length = 590 Score = 509 bits (1310), Expect = e-144, Method: Composition-based stats. Identities = 192/538 (35%), Positives = 292/538 (54%), Gaps = 22/538 (4%) Query: 3 DLEAVLADVSYLMAMEKSKATPAARASKK---ILLPEPSIRSVMQKYLEDRGEVTFEKIF 59 +LE ++A+ L A E ++ K + P S +++ ++ +K Sbjct: 2 ELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDK-- 59 Query: 60 SQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLA 119 Q +G LLFR FC + ++F + + +YE + +E+ ++I Y+ + Sbjct: 60 -QPIGRLLFRQFCETRPGL-ECYIQFLDSVAEYE-VTPDEKLGEKGKKIMTKYLTPKSPV 116 Query: 120 CSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKN 179 + + + L++K +LF + + + LRG+ F ++++S F RF QWK Sbjct: 117 FIAQVGQDLVSQTEEKLLQKPC-KELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKW 175 Query: 180 VELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 239 +E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE++ALNE Sbjct: 176 LERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNE 234 Query: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFY 297 + +L V + F+V ++YA+ T D L +L +MNGGDL +H+ G F E FY Sbjct: 235 KQILEKV---NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFY 291 Query: 298 AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-HASVGTHGY 356 AAEI+ GLE +H+ VYRDLKP NILLD++GH+RISDLGLA + VGT GY Sbjct: 292 AAEILCGLEDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGY 351 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK-DKHEIDRMTLTMAVELPD 415 MAPEVL Y S D++ LGC++++++ G SPFR K K + E+DR L Sbjct: 352 MAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 Query: 416 SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRG 475 FS E +S+ + LL +D +RLGC A EVK PFFR+++++ + PP +P Sbjct: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPR 470 Query: 476 EVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTINA 531 V D DI F KG+ L +D + Y F ++S WQ E+ ET F +N Sbjct: 471 AVYCKDVLDIEQFS--TVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNV 526 >2JDO-A nrPDB Length = 342 Score = 352 bits (904), Expect = 2e-97, Method: Composition-based stats. Identities = 123/345 (35%), Positives = 187/345 (54%), Gaps = 14/345 (4%) Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240 ++ +TMNDF +++G+G FG+V R+ TG+ YAMK L K+ I K + E Sbjct: 2 AMDPKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTES 61 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300 +L PF+ + YAF T D+L F+++ NGG+L +HLS+ VF+E RFY AE Sbjct: 62 RVLQ---NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAE 118 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK--PHASVGTHGYMA 358 I+ LE++H+R VVYRD+K N++LD+ GH++I+D GL + GT Y+A Sbjct: 119 IVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLA 178 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS 418 PEVL+ Y + DW+ LG ++++++ G PF +D + + L + P + S Sbjct: 179 PEVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFY---NQDHERLFELILMEEIRFPRTLS 234 Query: 419 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVN 478 PE +SLL GLL++D +RLG A+EV E FF S++WQ V +K PP P Sbjct: 235 PEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP-----Q 289 Query: 479 AADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAE 523 D FD+E T + L + +R +QE+ E Sbjct: 290 VTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQREEQEMFE 334 >3MV5-A nrPDB Length = 342 Score = 352 bits (903), Expect = 4e-97, Method: Composition-based stats. Identities = 117/328 (35%), Positives = 182/328 (55%), Gaps = 16/328 (4%) Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240 ++ +TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E Sbjct: 2 AMDPRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 61 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300 +L PF+ + Y+F T D+L F+++ NGG+L +HLS+ VFSE RFY AE Sbjct: 62 RVLQ---NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAE 118 Query: 301 IILGLEHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK--PHASVGTHGYM 357 I+ L+++H+ + VVYRDLK N++LD+ GH++I+D GL + K GT Y+ Sbjct: 119 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYL 178 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSF 417 APEVL+ Y + DW+ LG ++++++ G PF +D ++ + L + P + Sbjct: 179 APEVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFY---NQDHEKLFELILMEEIRFPRTL 234 Query: 418 SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEV 477 PE +SLL GLL++D +RLG A+E+ + FF + WQ V+ +K PP P Sbjct: 235 GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP----- 289 Query: 478 NAADAFDIGSFDEEDTKG-IKLLDSDQE 504 D FDEE T I + DQ+ Sbjct: 290 QVTSETDTRYFDEEFTAQMITITPPDQD 317 >5KCV-A nrPDB Length = 460 Score = 347 bits (891), Expect = 8e-96, Method: Composition-based stats. Identities = 114/314 (36%), Positives = 175/314 (55%), Gaps = 15/314 (4%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 +TMN+F +++G+G FG+V ++ TG+ YAMK L K+ I K L E + Sbjct: 156 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 215 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 L PF+ + Y+F T D+L F+++ NGG+L +HLS+ VFSE RFY AEI+ Sbjct: 216 LQ---NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 272 Query: 303 LGLEHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK--PHASVGTHGYMAP 359 L+++H+ + VVYRDLK N++LD+ GH++I+D GL + K GT Y+AP Sbjct: 273 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 332 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSP 419 EVL+ Y + DW+ LG ++++++ G PF +D ++ + L + P + P Sbjct: 333 EVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFY---NQDHEKLFELILMEEIRFPRTLGP 388 Query: 420 ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNA 479 E +SLL GLL++D +RLG A+E+ + FF + WQ V+ +K PP P Sbjct: 389 EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP-----QV 443 Query: 480 ADAFDIGSFDEEDT 493 D FDEE T Sbjct: 444 TSETDTRYFDEEFT 457 >5N23-A nrPDB Length = 352 Score = 346 bits (887), Expect = 2e-95, Method: Composition-based stats. Identities = 102/337 (30%), Positives = 178/337 (52%), Gaps = 10/337 (2%) Query: 158 RGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY 217 + ++F+ K +W++ N ++ F R +G G FG V + +TG Y Sbjct: 12 EQESVKEFLAKAKEDFLKKWESPAQNT-AHLDQFERIRTLGTGSFGRVMLVKHKETGNHY 70 Query: 218 AMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGG 277 AMK LDK+++ + LNE+ + + PF+V + ++F L +L+ GG Sbjct: 71 AMKILDKQKVVKLKQIEHTLNEKR---IQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGG 127 Query: 278 DLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLG 337 ++ HL + G FSE RFYAA+I+L E++H+ ++YRDLKP N+L+D+ G+++++D G Sbjct: 128 EMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFG 187 Query: 338 LACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK 397 A + P GT Y+APE++ Y+ + DW++LG +++++ G+ PF + Sbjct: 188 FAKRVKGRTPWTLCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 246 Query: 398 DKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 +I ++ V P FS +L+ LL LLQ D+ +R G L G ++K +F + D Sbjct: 247 ---QIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 303 Query: 458 WQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 494 W ++ +K P IP FD ++EE+ + Sbjct: 304 WIAIYQRKVEAPFIPKFKGPGDTSNFD--DYEEEEIR 338 >1FOT-A nrPDB Length = 318 Score = 346 bits (887), Expect = 3e-95, Method: Composition-based stats. Identities = 110/325 (33%), Positives = 181/325 (55%), Gaps = 12/325 (3%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 ++ DF + R +G G FG V+ R G+ YAMK L K+ + + +ER+MLS+V Sbjct: 4 SLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIV 63 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + PFI+ M F ++ I+D + GG+L L + F +FYAAE+ L LE Sbjct: 64 T---HPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALE 120 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGV 366 ++H++ ++YRDLKP NILLD++GH++I+D G A + + GT Y+APEV+ Sbjct: 121 YLHSKDIIYRDLKPENILLDKNGHIKITDFGFAK-YVPDVTYTLCGTPDYIAPEVVST-K 178 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLE 426 Y+ S DW+S G +++++L G++PF T +E L + P F+ +++ LL Sbjct: 179 PYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYE---KILNAELRFPPFFNEDVKDLLS 235 Query: 427 GLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGE-VNAADAFDI 485 L+ RD+++RLG L G ++VK P+F+ + W+ + + P PP + FD Sbjct: 236 RLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFD- 294 Query: 486 GSFDEEDTK-GIKLLDSDQELYRNF 509 + EED G++ D +L+R+F Sbjct: 295 -KYPEEDINYGVQGEDPYADLFRDF 318 >4L42-A nrPDB Length = 346 Score = 341 bits (876), Expect = 4e-94, Method: Composition-based stats. Identities = 116/332 (34%), Positives = 179/332 (53%), Gaps = 24/332 (7%) Query: 191 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 F + R++G+GG+G+V+ RK +TGK++AMK L K I +T + + +++ Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTA--HTKAERNILE 77 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 PFIV + YAF T KL IL+ ++GG+L L + G+F E FY AEI + L H Sbjct: 78 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH 137 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK--PHASVGTHGYMAPEVLQKG 365 +H + ++YRDLKP NI+L+ GHV+++D GL + H GT YMAPE+L + Sbjct: 138 LHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRS 197 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 ++ + DW+SLG +++ +L G PF K ID+ L + LP + E R LL Sbjct: 198 -GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKT--IDK-ILKCKLNLPPYLTQEARDLL 253 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDI 485 + LL+R+ RLG A EV+ PFFR ++W+ + +K PP P D+ Sbjct: 254 KKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLL-----QSEEDV 308 Query: 486 GSFDEEDTKGIKLLDSD--------QELYRNF 509 FD + T+ + D QE++R+F Sbjct: 309 SQFDSKFTRQTPVDSPDDSTLSEEEQEMFRDF 340 >4WB7-A nrPDB Length = 405 Score = 340 bits (873), Expect = 1e-93, Method: Composition-based stats. Identities = 104/351 (29%), Positives = 186/351 (52%), Gaps = 11/351 (3%) Query: 144 DLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFG 203 D+ + + G+ ++F+ K +W++ N ++ F + +G G FG Sbjct: 52 DVLSDPRKREIFDRYGEEVKEFLAKAKEDFLKKWESPAQNT-AHLDQFERIKTLGTGSFG 110 Query: 204 EVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHT 263 V + +TG YAMK LDK+++ + LNE+ +L V + PF+V + ++F Sbjct: 111 RVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV---NFPFLVKLEFSFKD 167 Query: 264 PDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANI 323 L +++ + GG++ HL + G FSE RFYAA+I+L E++H+ ++YRDLKP N+ Sbjct: 168 NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENL 227 Query: 324 LLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFK 383 L+D+ G+++++D G A K + GT Y+APE++ Y+ + DW++LG ++++ Sbjct: 228 LIDQQGYIQVTDFGFAKRV-KGRTWTLCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYE 285 Query: 384 LLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRG 443 + G+ PF + +I ++ V P FS +L+ LL LLQ D+ +R G L G Sbjct: 286 MAAGYPPFFADQPI---QIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNG 342 Query: 444 AQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 494 ++K +F + DW ++ +K P IP FD ++EE+ + Sbjct: 343 VNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFD--DYEEEEIR 391 >3TXO-A nrPDB Length = 353 Score = 340 bits (872), Expect = 1e-93, Method: Composition-based stats. Identities = 107/342 (31%), Positives = 176/342 (51%), Gaps = 17/342 (4%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 L +++F R++G+G FG+V R +TG +YA+K L K I + E+ +LS Sbjct: 19 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 78 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 L + PF+ + F TPD+L F+++ +NGGDL +H+ + F EA RFYAAEII Sbjct: 79 LAR--NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISA 136 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH--ASVGTHGYMAPEVL 362 L +H++ ++YRDLK N+LLD GH +++D G+ + GT Y+APE+L Sbjct: 137 LMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 196 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 Q+ + Y + DW+++G +L+++L GH+PF D + L V P + Sbjct: 197 QE-MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDD---LFEAILNDEVVYPTWLHEDAT 252 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQE-VKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAAD 481 +L+ + ++ RLG L +G + + PFF+ +DW + ++ PP P Sbjct: 253 GILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVS 312 Query: 482 AFDIGSFDEE------DTKGIKLLDSDQELYRNFPLTISERW 517 FD EE D + +++ D+ +RNF E Sbjct: 313 NFDPDFIKEEPVLTPIDEGHLPMINQDE--FRNFEYVSPELQ 352 >5D9K-A nrPDB Length = 330 Score = 340 bits (872), Expect = 1e-93, Method: Composition-based stats. Identities = 115/311 (36%), Positives = 179/311 (57%), Gaps = 13/311 (4%) Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLAL 237 E + + F + +++G+G FG+V+ +K D ++YAMK L K +K++ + Sbjct: 22 EGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKM 81 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFY 297 I++ + + PFIV + YAF T KL ILD + GGDL LS+ +F+E D++FY Sbjct: 82 ERDILVEV----NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFY 137 Query: 298 AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHG 355 AE+ L L+H+H+ ++YRDLKP NILLDE GH++++D GL+ + +KK ++ GT Sbjct: 138 LAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVE 197 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPD 415 YMAPEV+ + SADW+S G ++F++L G PF+ KD+ E M L + +P Sbjct: 198 YMAPEVVN-RRGHTQSADWWSFGVLMFEMLTGTLPFQG---KDRKETMTMILKAKLGMPQ 253 Query: 416 SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRG 475 SPE +SLL L +R+ RLG G +E+K FF ++DW ++ ++ PP P G Sbjct: 254 FLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATG 313 Query: 476 EVNAADAFDIG 486 FD Sbjct: 314 RPEDTFYFDPE 324 >2Z7Q-A nrPDB Length = 321 Score = 338 bits (866), Expect = 6e-93, Method: Composition-based stats. Identities = 112/306 (36%), Positives = 180/306 (58%), Gaps = 13/306 (4%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERI 241 + F + +++G+G FG+V+ RK D+G +YAMK L K +K++ + Sbjct: 24 KADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKME--- 80 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 +++ + PF+V + YAF T KL ILD + GGDL LS+ +F+E D++FY AE+ Sbjct: 81 -RDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAEL 139 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAP 359 LGL+H+H+ ++YRDLKP NILLDE GH++++D GL+ + +KK ++ GT YMAP Sbjct: 140 ALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAP 199 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSP 419 EV+ + + SADW+S G ++F++L G PF+ KD+ E + L + +P S Sbjct: 200 EVVNR-QGHSHSADWWSYGVLMFEMLTGSLPFQG---KDRKETMTLILKAKLGMPQFLST 255 Query: 420 ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNA 479 E +SLL L +R+ RLG GA+E+K F+ ++DW ++ ++ PP P + + Sbjct: 256 EAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDD 315 Query: 480 ADAFDI 485 FD Sbjct: 316 TFYFDT 321 >5X3F-B nrPDB Length = 393 Score = 338 bits (866), Expect = 7e-93, Method: Composition-based stats. Identities = 102/333 (30%), Positives = 178/333 (53%), Gaps = 11/333 (3%) Query: 162 FQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKC 221 Q F+ K +W+ N ++ F + +G G FG V + ++G YAMK Sbjct: 58 VQAFLAKAKEDFLKKWETPSQNT-AQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKI 116 Query: 222 LDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHY 281 LDK+++ + LNE+ +L V + PF+V + ++F L +++ + GG++ Sbjct: 117 LDKQKVVKLKQIEHTLNEKRILQAV---NFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFS 173 Query: 282 HLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD 341 HL + G FSE RFYAA+I+L E++H+ ++YRDLKP N+L+D+ G+++++D G A Sbjct: 174 HLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 233 Query: 342 FSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE 401 K + GT Y+APE++ Y+ + DW++LG +++++ G+ PF + + Sbjct: 234 V-KGRTWTLCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI---Q 288 Query: 402 IDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMV 461 I ++ V P FS +L+ LL LLQ D+ +R G L G ++K +F + DW + Sbjct: 289 IYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAI 348 Query: 462 FLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 494 + +K P IP FD ++EE+ + Sbjct: 349 YQRKVEAPFIPKFKGPGDTSNFD--DYEEEEIR 379 >4RA4-A nrPDB Length = 355 Score = 336 bits (861), Expect = 2e-92, Method: Composition-based stats. Identities = 105/324 (32%), Positives = 173/324 (53%), Gaps = 14/324 (4%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 + + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+ Sbjct: 16 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 75 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 L+ PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAEI +G Sbjct: 76 LLDKP--PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIG 133 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK--PHASVGTHGYMAPEVL 362 L +H R ++YRDLK N++LD GH++I+D G+ + GT Y+APE++ Sbjct: 134 LFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEII 193 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 Y S DW++ G +L+++L G PF +D+ E+ + + V P S S E Sbjct: 194 AY-QPYGKSVDWWAYGVLLYEMLAGQPPFDG---EDEDELFQSIMEHNVSYPKSLSKEAV 249 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482 S+ +GL+ + +RLGC G ++V+E FFR +DW+ + ++ PP P A Sbjct: 250 SICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVSGKGA--- 306 Query: 483 FDIGSFDEEDTKGIKLLDSDQELY 506 +FD+ T+G +L +L Sbjct: 307 ---ENFDKFFTRGQPVLTPPDQLV 327 >6E9W-A nrPDB Length = 443 Score = 336 bits (861), Expect = 3e-92, Method: Composition-based stats. Identities = 109/367 (29%), Positives = 178/367 (48%), Gaps = 21/367 (5%) Query: 138 KKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKF-TRFCQWKNVELNIHLTMNDFSVHRI 196 K +V D ++ + +L +K D F +R+ N ++ + D+ V ++ Sbjct: 50 KSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKV 109 Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IGRG FGEV R T K+YAMK L K + + ER +++ + P++V Sbjct: 110 IGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA---NSPWVVQ 166 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + YAF L +++ M GGDL +S + V E RFY AE++L L+ +H+ ++R Sbjct: 167 LFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWARFYTAEVVLALDAIHSMGFIHR 225 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKKP---HASVGTHGYMAPEVLQ---KGVAYDS 370 D+KP N+LLD+ GH++++D G +K+ +VGT Y++PEVL+ Y Sbjct: 226 DVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGR 285 Query: 371 SADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPD--SFSPELRSLLEGL 428 DW+S+G L+++L G +PF + M ++ PD S E ++L+ Sbjct: 286 ECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKI-MNHKNSLTFPDDNDISKEAKNLICAF 344 Query: 429 LQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSF 488 L D RLG G +E+K FF++ W L+ P++P FD Sbjct: 345 LT-DREVRLG--RNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFD---- 397 Query: 489 DEEDTKG 495 D E+ KG Sbjct: 398 DLEEDKG 404 >3PFQ-A nrPDB Length = 674 Score = 335 bits (858), Expect = 5e-92, Method: Composition-based stats. Identities = 107/331 (32%), Positives = 179/331 (54%), Gaps = 15/331 (4%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 + + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+ Sbjct: 337 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 396 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 L G PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAEI +G Sbjct: 397 L--PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 454 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVL 362 L + ++ ++YRDLK N++LD GH++I+D G+ + + GT Y+APE++ Sbjct: 455 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 514 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 Y S DW++ G +L+++L G +PF +D+ E+ + + V P S S E Sbjct: 515 AY-QPYGKSVDWWAFGVLLYEMLAGQAPFEG---EDEDELFQSIMEHNVAYPKSMSKEAV 570 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482 ++ +GL+ + +RLGC G +++KE FFR +DW+ + ++ PP P NA Sbjct: 571 AICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKASGRNA--- 627 Query: 483 FDIGSFDEEDTKGIKLL-DSDQELYRNFPLT 512 +FD T+ +L DQE+ RN + Sbjct: 628 ---ENFDRFFTRHPPVLTPPDQEVIRNIDQS 655 >1VZO-A nrPDB Length = 355 Score = 335 bits (858), Expect = 6e-92, Method: Composition-based stats. Identities = 116/312 (37%), Positives = 174/312 (55%), Gaps = 14/312 (4%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALNERI 241 + + +F + +++G G +G+V+ RK DTGK+YAMK L K I K T Sbjct: 50 KVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTER 109 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 + L PF+V + YAF T KL ILD +NGG+L HLSQ F+E +++ Y EI Sbjct: 110 QV-LEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 168 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP---HASVGTHGYMA 358 +L LEH+H ++YRD+K NILLD +GHV ++D GL+ +F + + GT YMA Sbjct: 169 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMA 228 Query: 359 PEVLQKG-VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-KHEIDRMTLTMAVELPDS 416 P++++ G +D + DW+SLG ++++LL G SPF K+ + EI R L P Sbjct: 229 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE 288 Query: 417 FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGE 476 S + L++ LL +D +RLGC R A E+KE FF+ ++W + +K P P P Sbjct: 289 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIR- 347 Query: 477 VNAADAFDIGSF 488 D D+ +F Sbjct: 348 ----DELDVSNF 355 >2I0E-A nrPDB Length = 353 Score = 333 bits (853), Expect = 2e-91, Method: Composition-based stats. Identities = 107/327 (32%), Positives = 178/327 (54%), Gaps = 15/327 (4%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 + + DF+ ++G+G FG+V + T ++YA+K L K + + E+ +L+ Sbjct: 16 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 75 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 L G PF+ + F T D+L F+++ +NGGDL YH+ Q G F E FYAAEI +G Sbjct: 76 L--PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 133 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVL 362 L + ++ ++YRDLK N++LD GH++I+D G+ + + GT Y+APE++ Sbjct: 134 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 193 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 Y S DW++ G +L+++L G +PF +D+ E+ + + V P S S E Sbjct: 194 AY-QPYGKSVDWWAFGVLLYEMLAGQAPFEG---EDEDELFQSIMEHNVAYPKSMSKEAV 249 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482 ++ +GL+ + +RLGC G +++KE FFR +DW+ + ++ PP P NA Sbjct: 250 AICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNA--- 306 Query: 483 FDIGSFDEEDTKGIKLL-DSDQELYRN 508 +FD T+ +L DQE+ RN Sbjct: 307 ---ENFDRFFTRHPPVLTPPDQEVIRN 330 >3HDN-A nrPDB Length = 373 Score = 331 bits (850), Expect = 4e-91, Method: Composition-based stats. Identities = 119/316 (37%), Positives = 170/316 (53%), Gaps = 14/316 (4%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 N H +DF ++IG+G FG+V R YA+K L KK I K+ E ++ER + Sbjct: 32 NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNV 91 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 L+ PF+V + ++F T DKL F+LD +NGG+L YHL + F E RFYAAEI Sbjct: 92 --LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 149 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPE 360 L ++H+ +VYRDLKP NILLD GH+ ++D GL + GT Y+APE Sbjct: 150 SALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPE 209 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 VL K YD + DW+ LG +L+++L G PF +++ E+ L ++L + + Sbjct: 210 VLHK-QPYDRTVDWWCLGAVLYEMLYGLPPFY---SRNTAEMYDNILNKPLQLKPNITNS 265 Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480 R LLEGLLQ+D +RLG E+K FF ++W + +K PP P N Sbjct: 266 ARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPN-- 322 Query: 481 DAFDIGSFDEEDTKGI 496 D+ FD E T+ Sbjct: 323 ---DLRHFDPEFTEEP 335 >5F9E-A nrPDB Length = 353 Score = 331 bits (848), Expect = 7e-91, Method: Composition-based stats. Identities = 115/347 (33%), Positives = 181/347 (52%), Gaps = 26/347 (7%) Query: 175 CQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGET 234 + L I L + DF +H+++G+G FG+V+ T + +A+K L K + M Sbjct: 5 LNKERPSLQIKLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVE 64 Query: 235 LALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADM 294 + E+ +LSL + PF+ M F T + L F+++ +NGGDL YH+ F + Sbjct: 65 CTMVEKRVLSL--AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRA 122 Query: 295 RFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVG 352 FYAAEIILGL+ +H++ +VYRDLK NILLD+ GH++I+D G+ + K + G Sbjct: 123 TFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCG 182 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE 412 T Y+APE+L G Y+ S DW+S G +L+++L G SPF ++ RM Sbjct: 183 TPDYIAPEILL-GQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPF--- 238 Query: 413 LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 472 P E + LL L R+ +RLG G ++++ P FR ++W+ + ++ PP P Sbjct: 239 YPRWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRP 294 Query: 473 PRGEVNAADAFDIGSFDEEDTKGIK--------LLDS-DQELYRNFP 510 FD +FD+E L++S DQ ++RNF Sbjct: 295 -----KVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFS 336 >5FET-A nrPDB Length = 847 Score = 326 bits (835), Expect = 3e-89, Method: Composition-based stats. Identities = 116/370 (31%), Positives = 187/370 (50%), Gaps = 12/370 (3%) Query: 136 LVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHR 195 L + + C + VF + I+ T + ++ + + M++ R Sbjct: 481 LYDEPRTASIISKATSVECWFVDKSVFLQIIQGPMLTHLEERIKMQ-DTKVEMHELETER 539 Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 IIGRG FG V T YA+KC+ K+ I + N ++ + + D PFI+ Sbjct: 540 IIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQN---NIKLEREITAENDHPFII 596 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 + F + F+ +L+ GG+L+ + + G+ S+ +FY IIL +E++H R +VY Sbjct: 597 RLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNIVY 656 Query: 316 RDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWF 375 RDLKP NILLD+ G+V++ D G A + + + VGT YMAPEV+ G Y + D + Sbjct: 657 RDLKPENILLDKQGYVKLIDFGCAKKI-QGRAYTLVGTPHYMAPEVIL-GKGYGCTVDIW 714 Query: 376 SLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS-PELRSLLEGLLQRDVN 434 +LG L++ + G PF + +D+ EI R LT + PD S + +L++ LL R Sbjct: 715 ALGVCLYEFICGPLPF-GNDQEDQLEIFRDILTGQLTFPDYVSDQDSINLMKRLLCRLPQ 773 Query: 435 RRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDT- 493 R+GC G +++KE FF + +W + + PPL+ +GE A D DI +EED Sbjct: 774 GRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLV-SKGETYAED-IDIKQIEEEDAL 831 Query: 494 -KGIKLLDSD 502 +G L D Sbjct: 832 NEGEPLDGDD 841 >3A8W-A nrPDB Length = 345 Score = 325 bits (834), Expect = 3e-89, Method: Composition-based stats. Identities = 106/334 (31%), Positives = 181/334 (54%), Gaps = 18/334 (5%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 L + DF + R+IGRG + +V R T ++YAMK + K+ + + E+ + Sbjct: 5 PLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE 64 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 S + PF+V + F T +L F+++ +NGGDL +H+ + E RFY+AEI L Sbjct: 65 QAS--NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLA 122 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVL 362 L ++H R ++YRDLK N+LLD GH++++D G+ + GT Y+APE+L Sbjct: 123 LNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEIL 182 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD------KHEIDRMTLTMAVELPDS 416 +G Y S DW++LG ++F+++ G SPF + D + + ++ L + +P S Sbjct: 183 -RGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRS 241 Query: 417 FSPELRSLLEGLLQRDVNRRLGCLGR-GAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRG 475 S + S+L+ L +D RLGC + G +++ PFFR++DW M+ ++ PP P Sbjct: 242 LSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKP--- 298 Query: 476 EVNAADAFDIGSFDEEDT-KGIKLLDSDQELYRN 508 N + F + +FD + T + ++L D ++ R Sbjct: 299 --NISGEFGLDNFDSQFTNEPVQLTPDDDDIVRK 330 >4RLP-A nrPDB Length = 288 Score = 323 bits (829), Expect = 1e-88, Method: Composition-based stats. Identities = 107/287 (37%), Positives = 163/287 (56%), Gaps = 11/287 (3%) Query: 191 FSVHRIIGRGGFGEVYGCRKA---DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 F + R++G+GG+G+V+ RK +TGK++AMK L K I +T + + +++ Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTA--HTKAERNILE 64 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 PFIV + YAF T KL IL+ ++GG+L L + G+F E FY AEI + L H Sbjct: 65 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH 124 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK--PHASVGTHGYMAPEVLQKG 365 +H + ++YRDLKP NI+L+ GHV+++D GL + H GT YMAPE+L + Sbjct: 125 LHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRS 184 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 ++ + DW+SLG +++ +L G PF K ID+ L + LP + E R LL Sbjct: 185 -GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKT--IDK-ILKCKLNLPPYLTQEARDLL 240 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 472 + LL+R+ RLG A EV+ PFFR ++W+ + +K PP P Sbjct: 241 KKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >5DYK-A nrPDB Length = 853 Score = 318 bits (815), Expect = 5e-87, Method: Composition-based stats. Identities = 121/429 (28%), Positives = 203/429 (47%), Gaps = 32/429 (7%) Query: 66 LLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDT-----YIMKELLAC 120 LL F EE +++ E ++ ++ E +V +++ T Y + L Sbjct: 429 LLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEIVKNKKRLRTLGKNDYFGERALLY 488 Query: 121 SHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV 180 P + S I V C + VF + I+ + + Sbjct: 489 DEPRTASVISKVN-----------------NVECWFVDKSVFLQIIQGPMLAHLEERIKM 531 Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240 + + + M++ RIIGRG FG V T YA+KC+ K+ I + N + Sbjct: 532 Q-DTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQN---NIK 587 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300 + + + D PFI+ + F F+ +L+ GG+L+ + + G+ S++ +FY Sbjct: 588 LEREITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGS 647 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE 360 IIL +E++H R +VYRDLKP NILLD+ G+V++ D G A + + + VGT YMAPE Sbjct: 648 IILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKV-QGRAYTLVGTPHYMAPE 706 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS-P 419 V+ G Y + D ++LG L++ + G PF + +D+ EI R LT + PD + Sbjct: 707 VIL-GKGYGCTVDIWALGICLYEFICGPLPF-GNDEEDQLEIFRDILTGQLTFPDYVTDT 764 Query: 420 ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNA 479 + +L++ LL R R+GC G +++K+ PFF + +W + + PPL+ + E A Sbjct: 765 DSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLV-SKSETYA 823 Query: 480 ADAFDIGSF 488 D DI Sbjct: 824 ED-IDIKQI 831 >6ED6-A nrPDB Length = 415 Score = 315 bits (807), Expect = 4e-86, Method: Composition-based stats. Identities = 101/368 (27%), Positives = 177/368 (48%), Gaps = 21/368 (5%) Query: 138 KKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKF-TRFCQWKNVELNIHLTMNDFSVHRI 196 + + + + + +L +K D F R+ + + + D+ V ++ Sbjct: 36 RSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKV 95 Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IGRG FGEV R + K+YAMK L K + + ER +++ + P++V Sbjct: 96 IGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA---NSPWVVQ 152 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 + YAF L +++ M GGDL +S + V E +FY AE++L L+ +H+ +++R Sbjct: 153 LFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWAKFYTAEVVLALDAIHSMGLIHR 211 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKKP---HASVGTHGYMAPEVLQ---KGVAYDS 370 D+KP N+LLD+HGH++++D G + +VGT Y++PEVL+ Y Sbjct: 212 DVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGR 271 Query: 371 SADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS--FSPELRSLLEGL 428 DW+S+G L+++L G +PF + M ++ P+ S ++L+ Sbjct: 272 ECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKI-MDHKNSLCFPEDAEISKHAKNLICAF 330 Query: 429 LQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSF 488 L D RLG G +E+++ PFF++ W +++ P++P + FD Sbjct: 331 LT-DREVRLG--RNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFD---- 383 Query: 489 DEEDTKGI 496 D ED KG Sbjct: 384 DIEDDKGD 391 >4OTD-A nrPDB Length = 341 Score = 308 bits (788), Expect = 6e-84, Method: Composition-based stats. Identities = 114/339 (33%), Positives = 183/339 (53%), Gaps = 15/339 (4%) Query: 180 VELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 239 + LT+ DF ++GRG FG+V +G+++A+K L K I + + E Sbjct: 3 MLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCE 62 Query: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAA 299 + +L+ V++ PF+V + F TP+ + F+++ GGDL H+ VFSE FY+A Sbjct: 63 KRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSA 121 Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVGTHGYM 357 ++LGL+ +H +VYRDLK N+LLD G+V+I+D GL + + GT ++ Sbjct: 122 CVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFL 181 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSF 417 APEVL +Y + DW+ LG +L+++L G SPF D+ E+ + V P Sbjct: 182 APEVLTD-TSYTRAVDWWGLGVLLYEMLVGESPFPGD---DEEEVFDSIVNDEVRYPRFL 237 Query: 418 SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEV 477 S E ++ LL+R+ RRLG R A++VK+ PFFR+L W+ + ++ PPP +P Sbjct: 238 SAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP----- 292 Query: 478 NAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISER 516 + D+ +FDEE T L ++ PLT +E+ Sbjct: 293 TLSGRTDVSNFDEEFTGEAPTLSPPRDAR---PLTAAEQ 328 >6BDL-A nrPDB Length = 347 Score = 306 bits (784), Expect = 2e-83, Method: Composition-based stats. Identities = 89/319 (27%), Positives = 159/319 (49%), Gaps = 9/319 (2%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKA-DTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 +L ++DF++ +G GGFG V + + K +AMK L K+ I + + +E+ Sbjct: 30 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEK--- 86 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 ++ FIV + F L +++ GG+L L G F ++ RFY A ++ Sbjct: 87 QIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE 146 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVL 362 ++H++ ++YRDLKP N++LD G+ ++ D G A KK GT Y+APE++ Sbjct: 147 AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII 206 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 +D SAD++SLG ++++LL G PF + I + M +E P + Sbjct: 207 L-NKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM-IEFPKKIAKNAA 264 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482 +L++ L + + + RLG L G +++++ +F +W+ + PP+IP Sbjct: 265 NLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSN 324 Query: 483 FDIGSFDEEDTKGIKLLDS 501 FD SF E++ + +S Sbjct: 325 FD--SFPEDNDEPPPDDNS 341 >3TKU-A nrPDB Length = 433 Score = 304 bits (778), Expect = 1e-82, Method: Composition-based stats. Identities = 99/349 (28%), Positives = 164/349 (46%), Gaps = 27/349 (7%) Query: 168 SDKFTRFCQWK----NVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD 223 F +W + + L DF + ++IGRG FGEV + +T ++YAMK L+ Sbjct: 65 DKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILN 124 Query: 224 KKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL 283 K + + ER + + GDC +I + YAF + L ++D GGDL L Sbjct: 125 KWEMLKRAETACFREERDV---LVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLL 181 Query: 284 SQ-HGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF 342 S+ E RFY E++L ++ +H V+RD+KP N+LLD +GH+R++D G Sbjct: 182 SKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKM 241 Query: 343 SKKKP---HASVGTHGYMAPEVLQ----KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHK 395 + +VGT Y++PE+LQ Y DW+SLG ++++L G +PF Sbjct: 242 NDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAES 301 Query: 396 TKDKHEIDRMTLTMAVELPDS---FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPF 452 + + M + P S E + L++ L+ RRLG G ++ K+ F Sbjct: 302 LVETYGKI-MNHEERFQFPSHVTDVSEEAKDLIQRLIC-SRERRLG--QNGIEDFKKHAF 357 Query: 453 FRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDS 501 F L+W+ + + P IP + FD+ D++ + ++L Sbjct: 358 FEGLNWENI--RNLEAPYIPDVSSPSDTSNFDV---DDDVLRNTEILPP 401 >4CRS-A nrPDB Length = 341 Score = 300 bits (768), Expect = 1e-81, Method: Composition-based stats. Identities = 110/338 (32%), Positives = 176/338 (52%), Gaps = 22/338 (6%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + DF ++ RG FG+V +T +M+A+K L K I + + E+ + Sbjct: 7 FQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIF 66 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 V++ PF+V + F T + + F+++ GGDL H+ VFSE FYAA ++L Sbjct: 67 ETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPRAVFYAACVVL 125 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK--KKPHASVGTHGYMAPEV 361 GL+++H +VYRDLK N+LLD G V+I+D GL + + GT ++APEV Sbjct: 126 GLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 185 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 L + +Y + DW+ LG +++++L G SPF D+ E+ + V P S E Sbjct: 186 LTE-TSYTRAVDWWGLGVLIYEMLVGESPFPGD---DEEEVFDSIVNDEVRYPRFLSTEA 241 Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAAD 481 S++ LL+R+ RRLG + A++VK+ PFFR +DW + +K PP IP Sbjct: 242 ISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGRE--- 298 Query: 482 AFDIGSFDEEDTKGIKLLDS----------DQELYRNF 509 D+ +FD+E T +L +QE++R+F Sbjct: 299 --DVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDF 334 >4AW2-A nrPDB Length = 437 Score = 296 bits (759), Expect = 2e-80, Method: Composition-based stats. Identities = 93/335 (27%), Positives = 151/335 (45%), Gaps = 24/335 (7%) Query: 168 SDKFTRFCQWKNV----ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD 223 + +W + L DF + ++IGRG FGEV + + K++AMK L+ Sbjct: 49 EKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILN 108 Query: 224 KKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL 283 K + + ER + + GD +I + YAF + L ++D GGDL L Sbjct: 109 KWEMLKRAETACFREERDV---LVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLL 165 Query: 284 SQ-HGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF 342 S+ E RFY AE+++ ++ +H V+RD+KP NIL+D +GH+R++D G Sbjct: 166 SKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL 225 Query: 343 SKKKP---HASVGTHGYMAPEVLQ----KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHK 395 + +VGT Y++PE+LQ Y DW+SLG ++++L G +PF Sbjct: 226 MEDGTVQSSVAVGTPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAES 285 Query: 396 TKDKHEIDRMTLTMAVELP---DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPF 452 + + M + P S + L+ L+ RLG G ++ K+ PF Sbjct: 286 LVETYGKI-MNHKERFQFPTQVTDVSENAKDLIRRLIC-SREHRLG--QNGIEDFKKHPF 341 Query: 453 FRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGS 487 F +DW + + P IP FD+ Sbjct: 342 FSGIDWDNI--RNCEAPYIPEVSSPTDTSNFDVDD 374 >4FR4-A nrPDB Length = 384 Score = 293 bits (751), Expect = 2e-79, Method: Composition-based stats. Identities = 103/307 (33%), Positives = 170/307 (55%), Gaps = 10/307 (3%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 N + + F + R IG+G FG+V +K DT KMYAMK ++K++ + E Sbjct: 9 NEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKE--- 65 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 L ++ + PF+V + Y+F + + ++DL+ GGDL YHL Q+ F E ++ + E++ Sbjct: 66 LQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELV 125 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-HASVGTHGYMAPEV 361 + L+++ N+ +++RD+KP NILLDEHGHV I+D +A ++ GT YMAPE+ Sbjct: 126 MALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEM 185 Query: 362 LQ--KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSP 419 KG Y + DW+SLG ++LLRG P+ + EI T V P ++S Sbjct: 186 FSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQ 245 Query: 420 ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNA 479 E+ SLL+ LL+ + ++R L +V+ P+ ++W VF ++ P IP +G +N Sbjct: 246 EMVSLLKKLLEPNPDQRFSQLS----DVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLNC 301 Query: 480 ADAFDIG 486 F++ Sbjct: 302 DPTFELE 308 >5JN2-A nrPDB Length = 525 Score = 292 bits (748), Expect = 3e-79, Method: Composition-based stats. Identities = 75/278 (26%), Positives = 132/278 (47%), Gaps = 15/278 (5%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + R++G+G FGEV C+ TG+ A+K + K+++K K + L E + L+ Sbjct: 67 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLRE---VQLLKQ 123 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 D P I+ + F + ++ GG+L + FSE D +++ G+ +M Sbjct: 124 LDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYM 183 Query: 309 HNRFVVYRDLKPANILL---DEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQK 364 H +V+RDLKP N+LL + ++RI D GL+ F KK +GT Y+APEVL Sbjct: 184 HKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHG 243 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-KHEIDRMTLTMAVELPDSFSPELRS 423 YD D +S G +L+ LL G PF D ++++ T + S + Sbjct: 244 --TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKD 301 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMV 461 L+ +L + R+ A++ + + ++ + + Sbjct: 302 LIRKMLTYVPSMRI-----SARDALDHEWIQTYTKEQI 334 >3ZUT-A nrPDB Length = 362 Score = 291 bits (745), Expect = 8e-79, Method: Composition-based stats. Identities = 84/327 (25%), Positives = 141/327 (43%), Gaps = 35/327 (10%) Query: 180 VELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 239 ++L I + + + + IG G FG R + ++ A+K + ++GE + N Sbjct: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI-------ERGEKIDENV 62 Query: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAA 299 + + + P IV TP L+ +++ +GG+L + G FSE + RF+ Sbjct: 63 KREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEH--GHVRISDLGLAC-DFSKKKPHASVGTHGY 356 ++I G+ + H V +RDLK N LLD ++I G + +P ++VGT Y Sbjct: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAY 182 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQH-KTKDKHEIDRMTLTMAVELPD 415 +APEVL K AD +S G L+ +L G PF + K+ + L + +PD Sbjct: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD 242 Query: 416 --SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPP 473 SPE R L+ + D +R+ E++ +F L+ P L+ Sbjct: 243 YVHISPECRHLISRIFVADPAKRISI-----PEIRNHEWF---------LKNLPADLM-- 286 Query: 474 RGEVNAADAFDIGSFDEEDTKGIKLLD 500 D FDE D G + + Sbjct: 287 ------NDNTMTTQFDESDQPGQSIEE 307 >3ORZ-A nrPDB Length = 316 Score = 290 bits (743), Expect = 1e-78, Method: Composition-based stats. Identities = 99/286 (34%), Positives = 159/286 (55%), Gaps = 14/286 (4%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 DF +I+G G F V R+ T + YA+K L+K+ I + ER ++S + Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-- 94 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 D PF V + + F +KL F L G+L ++ + G F E RFY AEI+ LE++ Sbjct: 95 -DHPFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYL 153 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK----KPHASVGTHGYMAPEVLQK 364 H + +++RDLKP NILL+E H++I+D G A S + + ++ VGT Y++PE+L + Sbjct: 154 HGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE 213 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 424 A S+D ++LGC++++L+ G PFR +++ I + + + + P+ F P+ R L Sbjct: 214 KSAC-KSSDLWALGCIIYQLVAGLPPFRAG---NEYLIFQKIIKLEYDFPEKFFPKARDL 269 Query: 425 LEGLLQRDVNRRLGCLG-RGAQEVKESPFFRSLDWQMVFLQKYPPP 469 +E LL D +RLGC G +K PFF S+ W+ + Q PP Sbjct: 270 VEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPP 313 >4CFF-A nrPDB Length = 571 Score = 289 bits (739), Expect = 4e-78, Method: Composition-based stats. Identities = 77/311 (24%), Positives = 137/311 (44%), Gaps = 23/311 (7%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 + + + + +G G FG+V TG A+K L++++I+ E L Sbjct: 29 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 88 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 L P I+ + TP +++ ++GG+L ++ +HG E + R +I+ Sbjct: 89 LFR---HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 145 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQ 363 +++ H VV+RDLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ Sbjct: 146 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 205 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 + D +S G +L+ LL G PF + + +P+ + + + Sbjct: 206 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPT---LFKKIRGGVFYIPEYLNRSVAT 262 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP--PRGEVNAAD 481 LL +LQ D +R ++++E +F+ Q P L P P + N D Sbjct: 263 LLMHMLQVDPLKRATI-----KDIREHEWFK---------QDLPSYLFPEDPSYDANVID 308 Query: 482 AFDIGSFDEED 492 + E+ Sbjct: 309 DEAVKEVCEKF 319 >2QNJ-A nrPDB Length = 328 Score = 288 bits (738), Expect = 5e-78, Method: Composition-based stats. Identities = 73/300 (24%), Positives = 136/300 (45%), Gaps = 18/300 (6%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 + ++ + + IG+G F +V R TG+ A+K +DK ++ + L RIM L Sbjct: 10 HIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKIL- 68 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + P IV + T L I++ +GG++ +L HG E + R +I+ ++ Sbjct: 69 ---NHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQ 125 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKG 365 + H + +V+RDLK N+LLD +++I+D G + +F+ K G+ Y APE+ Q Sbjct: 126 YCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGK 185 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 D +SLG +L+ L+ G PF ++ E+ L +P S + +LL Sbjct: 186 KYDGPEVDVWSLGVILYTLVSGSLPFDG---QNLKELRERVLRGKYRIPFYMSTDCENLL 242 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDI 485 + L + +R +++ + + + P + P +++ DI Sbjct: 243 KRFLVLNPIKR-----GTLEQIMKDRWI-----NAGHEEDELKPFVEPELDISDQKRIDI 292 >4REW-A nrPDB Length = 540 Score = 288 bits (737), Expect = 6e-78, Method: Composition-based stats. Identities = 77/298 (25%), Positives = 135/298 (45%), Gaps = 18/298 (6%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 + + + + +G G FG+V + TG A+K L++++I+ E L L Sbjct: 3 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKL 62 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 P I+ + TP + +++ ++GG+L ++ ++G E + R +I+ G+ Sbjct: 63 FR---HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGV 119 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQK 364 ++ H VV+RDLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ Sbjct: 120 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 179 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 424 + D +S G +L+ LL G PF + + P +P + SL Sbjct: 180 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPT---LFKKICDGIFYTPQYLNPSVISL 236 Query: 425 LEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482 L+ +LQ D +R ++++E +F+ L KY P P D Sbjct: 237 LKHMLQVDPMKRASI-----KDIREHEWFKQ------DLPKYLFPEDPSYSSTMIDDE 283 >3MA6-A nrPDB Length = 298 Score = 288 bits (736), Expect = 7e-78, Method: Composition-based stats. Identities = 75/277 (27%), Positives = 131/277 (47%), Gaps = 15/277 (5%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + R++G+G FGEV C+ TG+ A+K + K+++K K + L E + L+ Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLRE---VQLLKQ 88 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 D P I+ + F + ++ GG+L + FSE D +++ G+ +M Sbjct: 89 LDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYM 148 Query: 309 HNRFVVYRDLKPANILL---DEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQK 364 H +V+RDLKP N+LL + ++RI D GL+ F KK +GT Y+APEVL Sbjct: 149 HKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHG 208 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-KHEIDRMTLTMAVELPDSFSPELRS 423 YD D +S G +L+ LL G PF D ++++ T + S + Sbjct: 209 --TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKD 266 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQM 460 L+ +L + R+ A++ + + ++ + Sbjct: 267 LIRKMLTYVPSMRI-----SARDALDHEWIQTYTKEQ 298 >5EZV-A nrPDB Length = 560 Score = 287 bits (735), Expect = 9e-78, Method: Composition-based stats. Identities = 77/311 (24%), Positives = 137/311 (44%), Gaps = 23/311 (7%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 + + + + +G G FG+V TG A+K L++++I+ E L Sbjct: 24 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 83 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 L P I+ + TP +++ ++GG+L ++ +HG E + R +I+ Sbjct: 84 LFR---HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 140 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQ 363 +++ H VV+RDLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ Sbjct: 141 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 200 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 + D +S G +L+ LL G PF + + +P+ + + + Sbjct: 201 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPT---LFKKIRGGVFYIPEYLNRSVAT 257 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP--PRGEVNAAD 481 LL +LQ D +R ++++E +F+ Q P L P P + N D Sbjct: 258 LLMHMLQVDPLKRATI-----KDIREHEWFK---------QDLPSYLFPEDPSYDANVID 303 Query: 482 AFDIGSFDEED 492 + E+ Sbjct: 304 DEAVKEVCEKF 314 >3UDB-A nrPDB Length = 317 Score = 287 bits (734), Expect = 1e-77, Method: Composition-based stats. Identities = 85/327 (25%), Positives = 142/327 (43%), Gaps = 35/327 (10%) Query: 180 VELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 239 ++L I + + + + IG G FG R ++ A+K + ++GE + N Sbjct: 10 MDLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYI-------ERGEKIDENV 62 Query: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAA 299 + + + P IV TP L+ +++ +GG+L + G FSE + RF+ Sbjct: 63 KREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ 122 Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEH--GHVRISDLGLACD-FSKKKPHASVGTHGY 356 ++I G+ + H V +RDLK N LLD ++I+D G + +P ++VGT Y Sbjct: 123 QLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAY 182 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQH-KTKDKHEIDRMTLTMAVELPD 415 +APEVL K AD +S G L+ +L G PF + K+ + L + +PD Sbjct: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD 242 Query: 416 --SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPP 473 SPE R L+ + D +R+ E++ +F L+ P L+ Sbjct: 243 YVHISPECRHLISRIFVADPAKRISI-----PEIRNHEWF---------LKNLPADLM-- 286 Query: 474 RGEVNAADAFDIGSFDEEDTKGIKLLD 500 D FDE D G + + Sbjct: 287 ------NDNTMTTQFDESDQPGQSIEE 307 >5KZ7-A nrPDB Length = 346 Score = 287 bits (734), Expect = 1e-77, Method: Composition-based stats. Identities = 74/292 (25%), Positives = 138/292 (47%), Gaps = 15/292 (5%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 + ++ + + IG+G F +V R TGK A+K +DK ++ + L RIM Sbjct: 31 HIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIM---- 86 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + P IV + T L +++ +GG++ +L HG E + R +I+ ++ Sbjct: 87 KVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 146 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKG 365 + H +F+V+RDLK N+LLD +++I+D G + +F+ K G+ Y APE+ Q Sbjct: 147 YCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGK 206 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 D +SLG +L+ L+ G PF ++ E+ L +P S + +LL Sbjct: 207 KYDGPEVDVWSLGVILYTLVSGSLPFDG---QNLKELRERVLRGKYRIPFYMSTDCENLL 263 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEV 477 + L + ++R +++ + + ++ + L+ Y PL P + Sbjct: 264 KKFLILNPSKR-----GTLEQIMKDRWM-NVGHEDDELKPYVEPL-PDYKDP 308 >2VD5-A nrPDB Length = 412 Score = 286 bits (733), Expect = 2e-77, Method: Composition-based stats. Identities = 102/350 (29%), Positives = 162/350 (46%), Gaps = 29/350 (8%) Query: 153 ICQNLRGDVFQKFIESDKFTR-FCQWKNVEL----NIHLTMNDFSVHRIIGRGGFGEVYG 207 + Q L + DK+ F QW + + L +DF + ++IGRG F EV Sbjct: 24 VHQELGASE----LAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAV 79 Query: 208 CRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKL 267 + TG++YAMK ++K + + + ER + + GD +I + +AF + L Sbjct: 80 VKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDV---LVNGDRRWITQLHFAFQDENYL 136 Query: 268 SFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD 326 +++ GGDL LS+ G RFY AEI++ ++ +H V+RD+KP NILLD Sbjct: 137 YLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLD 196 Query: 327 EHGHVRISDLGLACDFSKKKPHAS---VGTHGYMAPEVLQ------KGVAYDSSADWFSL 377 GH+R++D G S VGT Y++PE+LQ +Y DW++L Sbjct: 197 RCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 256 Query: 378 GCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDS-FSPELRSLLEGLLQRDVNR 435 G +++ G +PF T + + +I +++ L D E R ++ LL Sbjct: 257 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCP-PET 315 Query: 436 RLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDI 485 RLG GA + + PFF LDW + + PP P FD+ Sbjct: 316 RLG--RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFEGATDTCNFDL 361 >5ES1-A nrPDB Length = 328 Score = 286 bits (733), Expect = 2e-77, Method: Composition-based stats. Identities = 73/281 (25%), Positives = 131/281 (46%), Gaps = 14/281 (4%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 ++ + R IG+G F +V R TG+ A+K +DK ++ + L RIM L Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGL---- 71 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 + P IV + T L +++ + G++ +L HG E + R +I+ + + H Sbjct: 72 NHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCH 131 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKGVAY 368 + +V+RDLK N+LLD +++I+D G + +F+ K G+ Y APE+ Q Sbjct: 132 QKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYD 191 Query: 369 DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGL 428 D +SLG +L+ L+ G PF H K+ E L +P S + S+L Sbjct: 192 GPEVDIWSLGVILYTLVSGSLPFDGHNLKELRE---RVLRGKYRVPFYMSTDCESILRRF 248 Query: 429 LQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPP 469 L + +R +++ + + ++ ++ L+ Y P Sbjct: 249 LVLNPAKR-----CTLEQIMKDKWI-NIGYEGEELKPYTEP 283 >4RED-A nrPDB Length = 351 Score = 286 bits (732), Expect = 2e-77, Method: Composition-based stats. Identities = 81/325 (24%), Positives = 146/325 (44%), Gaps = 29/325 (8%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 + + + + +G G FG+V + TG A+K L++++I+ E L L Sbjct: 11 VKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKL 70 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 P I+ + TP + +++ ++GG+L ++ ++G E + R +I+ G+ Sbjct: 71 FR---HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGV 127 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQK 364 ++ H VV+RDLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ Sbjct: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 424 + D +S G +L+ LL G PF + + P +P + SL Sbjct: 188 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPT---LFKKICDGIFYTPQYLNPSVISL 244 Query: 425 LEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFD 484 L+ +LQ D +R ++++E +F+ Q P L P ++ Sbjct: 245 LKHMLQVDPMKRASI-----KDIREHEWFK---------QDLPKYLFPE------DPSYS 284 Query: 485 IGSFDEEDTKGI--KLLDSDQELYR 507 D+E K + K S++E+ Sbjct: 285 TTMIDDEALKEVCEKFECSEEEVLS 309 >3MN3-A nrPDB Length = 271 Score = 286 bits (731), Expect = 3e-77, Method: Composition-based stats. Identities = 71/288 (24%), Positives = 128/288 (44%), Gaps = 22/288 (7%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 + ++ + + +G G FG+V TG+ A+K ++KK + + E L L+ Sbjct: 2 HIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLL 61 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 P I+ + + D++ +++ G +L ++ Q SE + R + +II +E Sbjct: 62 R---HPHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVE 117 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKG 365 + H +V+RDLKP N+LLDEH +V+I+D GL+ + S G+ Y APEV+ Sbjct: 118 YCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGK 177 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 + D +S G +L+ +L PF + + LP SP L+ Sbjct: 178 LYAGPEVDVWSCGVILYVMLCRRLPFDDESIP---VLFKNISNGVYTLPKFLSPGAAGLI 234 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPP 473 + +L + R+ E+ + +F+ P L+PP Sbjct: 235 KRMLIVNPLNRISIH-----EIMQDDWFKV---------DLPEYLLPP 268 >5FG8-A nrPDB Length = 285 Score = 286 bits (731), Expect = 3e-77, Method: Composition-based stats. Identities = 77/274 (28%), Positives = 130/274 (47%), Gaps = 22/274 (8%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ + +G+G F V C + TG +A K ++ K++ + + L RI L Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKL--- 70 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 P IV + + + + DL+ GG+L + +SEAD +I+ + H Sbjct: 71 -HHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHC 129 Query: 309 HNRFVVYRDLKPANILLDEHGH---VRISDLGLACDFSKKK--PHASVGTHGYMAPEVLQ 363 H VV+RDLKP N+LL V+++D GLA + GT GY++PEVL Sbjct: 130 HQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL- 188 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSP 419 K Y S D ++ G +L+ LL G+ PF +D+H + A + P D+ +P Sbjct: 189 KKEPYGKSVDIWACGVILYILLVGYPPFWD---EDQHRLYSQIKAGAYDYPSPEWDTVTP 245 Query: 420 ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 E ++L+ +L + N+R+ A E + P+ Sbjct: 246 EAKNLINQMLTVNPNKRI-----TAAEALKHPWI 274 >5WAX-A nrPDB Length = 310 Score = 285 bits (730), Expect = 3e-77, Method: Composition-based stats. Identities = 77/295 (26%), Positives = 132/295 (44%), Gaps = 23/295 (7%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + + R IG G FG R G++ A+K +++ + + +N R + Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHR-------S 63 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 P I+ TP L+ +++ +GG+L + G FSE + RF+ ++I G+ + Sbjct: 64 LRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 123 Query: 309 HNRFVVYRDLKPANILLDEHG--HVRISDLGLAC-DFSKKKPHASVGTHGYMAPEVLQKG 365 H+ V +RDLK N LLD ++I D G + +P ++VGT Y+APEVL K Sbjct: 124 HSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 183 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAVELPD--SFSPELR 422 AD +S G L+ +L G PF + K+ + + L + +PD SPE + Sbjct: 184 EYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPECQ 243 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFF-----RSLDWQMVFLQKYPPPLIP 472 L+ + + R+ E++ P+F L ++Y P P Sbjct: 244 DLISRIFVANPATRITI-----PEIRNHPWFLKNLPADLMDDSTMSKQYEEPEQP 293 >4YZB-A nrPDB Length = 491 Score = 284 bits (728), Expect = 7e-77, Method: Composition-based stats. Identities = 79/274 (28%), Positives = 133/274 (48%), Gaps = 15/274 (5%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + R++G+G FGEV C+ TG+ YA+K + K+++K K + L L + L+ Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLL---KEVELLKK 86 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 D P I+ + F + ++ GG+L + FSE D +++ G+ +M Sbjct: 87 LDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYM 146 Query: 309 HNRFVVYRDLKPANILLD---EHGHVRISDLGLACDF-SKKKPHASVGTHGYMAPEVLQK 364 H +V+RDLKP N+LL+ + ++RI D GL+ F S KK +GT Y+APEVL Sbjct: 147 HKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHG 206 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-KHEIDRMTLTMAVELPDSFSPELRS 423 YD D +S G +L+ LL G PF D ++++ T + S + Sbjct: 207 --TYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKD 264 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 L+ +L R+ A++ E + ++ D Sbjct: 265 LIRKMLAYVPTMRI-----SARDALEHEWLKTTD 293 >2YZA-A nrPDB Length = 276 Score = 284 bits (727), Expect = 8e-77, Method: Composition-based stats. Identities = 73/290 (25%), Positives = 130/290 (44%), Gaps = 21/290 (7%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 + + + + +G G FG+V TG A+K L++++I+ E L Sbjct: 7 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 66 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 L P I+ + TP +++ ++GG+L ++ +HG E + R +I+ Sbjct: 67 LFR---HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 123 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQ 363 +++ H VV+RDLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ Sbjct: 124 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVIS 183 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 + D +S G +L+ LL G PF + + +P+ + + + Sbjct: 184 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPT---LFKKIRGGVFYIPEYLNRSVAT 240 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPP 473 LL +LQ D +R ++++E +F+ Q P L P Sbjct: 241 LLMHMLQVDPLKRATI-----KDIREHEWFK---------QDLPSYLFPE 276 >4CFH-A nrPDB Length = 493 Score = 283 bits (725), Expect = 1e-76, Method: Composition-based stats. Identities = 77/299 (25%), Positives = 135/299 (45%), Gaps = 18/299 (6%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 + + + + +G G FG+V + TG A+K L++++I+ E L Sbjct: 29 RVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK 88 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 L P I+ + TP + +++ ++GG+L ++ ++G E + R +I+ G Sbjct: 89 LFR---HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSG 145 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQ 363 +++ H VV+RDLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ Sbjct: 146 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 205 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 + D +S G +L+ LL G PF + + P +P + S Sbjct: 206 GRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPT---LFKKICDGIFYTPQYLNPSVIS 262 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADA 482 LL+ +LQ D +R ++++E +F+ L KY P P D Sbjct: 263 LLKHMLQVDPMKRATI-----KDIREHEWFKQ------DLPKYLFPEDPSYSSTMIDDE 310 >2BDW-A nrPDB Length = 362 Score = 283 bits (723), Expect = 3e-76, Method: Composition-based stats. Identities = 74/273 (27%), Positives = 132/273 (48%), Gaps = 21/273 (7%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ V +G+G F V C TG +A K ++ K++ + + L RI L Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKL--- 85 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 P IV + + + DL+ GG+L + +SEAD +I+ + + Sbjct: 86 -QHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYC 144 Query: 309 HNRFVVYRDLKPANILLDEHGH---VRISDLGLACDFSKKKP-HASVGTHGYMAPEVLQK 364 H+ +V+R+LKP N+LL V+++D GLA + + + H GT GY++PEVL+K Sbjct: 145 HSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 204 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSPE 420 Y D ++ G +L+ LL G+ PF +D+H + A + P D+ +PE Sbjct: 205 D-PYSKPVDIWACGVILYILLVGYPPFWD---EDQHRLYAQIKAGAYDYPSPEWDTVTPE 260 Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 +SL++ +L + +R+ A + + P+ Sbjct: 261 AKSLIDSMLTVNPKKRI-----TADQALKVPWI 288 >5LOH-A nrPDB Length = 341 Score = 282 bits (722), Expect = 3e-76, Method: Composition-based stats. Identities = 90/312 (28%), Positives = 153/312 (49%), Gaps = 27/312 (8%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 ++ +FS+ + I RG FG+VY +K GK+YA+K + K + K ER L+L Sbjct: 34 SIEEFSIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALS 91 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + PFIV + Y+ + + + +++ + GGD+ L +G F E Y +E+ L L+ Sbjct: 92 KS---PFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALD 148 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC--------DFSKKKPHASVGTHGYMA 358 ++H +++RDLKP N+L+ GH++++D GL+ GT Y+A Sbjct: 149 YLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLA 208 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP---D 415 PE+L G A+ + DW++LG LF+ L G PF + ++ + L + P + Sbjct: 209 PELLL-GRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQ---QVFQNILKRDIPWPEGEE 264 Query: 416 SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRG 475 S +S +E LL D +R G +E+K P F +DW+ + Q P IP Sbjct: 265 KLSDNAQSAVEILLTIDDTKRAGM-----KELKRHPLFSDVDWENL--QHQTMPFIPQPD 317 Query: 476 EVNAADAFDIGS 487 + F+ + Sbjct: 318 DETDTSYFEARN 329 >5IG1-A nrPDB Length = 344 Score = 282 bits (721), Expect = 4e-76, Method: Composition-based stats. Identities = 71/270 (26%), Positives = 134/270 (49%), Gaps = 21/270 (7%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 +IG+G F V+ C TG++ A+K + K ++ + + + + + S+ IV Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKI----KREIGICSSLQHEHIV 79 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 M AF + + ++GG+L + ++E D +I+ L+H H++ +++ Sbjct: 80 SMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIH 139 Query: 316 RDLKPANILL---DEHGHVRISDLGLACDFSKKKPH-ASVGTHGYMAPEVLQKGVAYDSS 371 RDLKP N+LL D + V+I+D GLA + + GT GY++PEV+ + V YD++ Sbjct: 140 RDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVI-RRVPYDTA 198 Query: 372 ADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSPELRSLLEG 427 D ++ G +L+ LL G+ PF + +D ++ + P DS + + L++ Sbjct: 199 VDVWACGVILYILLVGYPPFWE---EDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKA 255 Query: 428 LLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 +L+ + RR QE+ + P+ D Sbjct: 256 MLEPNPKRR-----PTVQELLQHPWIARRD 280 >4FG9-A nrPDB Length = 320 Score = 282 bits (721), Expect = 4e-76, Method: Composition-based stats. Identities = 69/270 (25%), Positives = 129/270 (47%), Gaps = 16/270 (5%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + ++G G F EV T K+ A+KC+ K+ ++ K+G ++++ Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSM-----ENEIAVLHKIK 74 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P IV + + + L I+ L++GG+L + + G ++E D +++ ++++H+ Sbjct: 75 HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHD 134 Query: 311 RFVVYRDLKPANIL---LDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGV 366 +V+RDLKP N+L LDE + ISD GL+ + GT GY+APEVL + Sbjct: 135 LGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQ-K 193 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 Y + D +S+G + + LL G+ PF + K +I + D S + + Sbjct: 194 PYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFI 253 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 L+++D +R C ++ + P+ Sbjct: 254 RHLMEKDPEKRFTC-----EQALQHPWIAG 278 >3H4J-B nrPDB Length = 336 Score = 282 bits (721), Expect = 4e-76, Method: Composition-based stats. Identities = 65/270 (24%), Positives = 127/270 (47%), Gaps = 13/270 (4%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 + + + +G G FG+V T + A+K + ++ +K + + +S Sbjct: 5 KRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSD---MHMRVEREIS 61 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 + P I+ + TP + +++ GG+L ++ + +E + R + +II Sbjct: 62 YLKLLRHPHIIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICA 120 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQ 363 +E+ H +V+RDLKP N+LLD++ +V+I+D GL+ + S G+ Y APEV+ Sbjct: 121 IEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVIN 180 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 + D +S G +L+ +L G PF + + + + +PD SP +S Sbjct: 181 GKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPN---LFKKVNSCVYVMPDFLSPGAQS 237 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 L+ ++ D +R+ QE++ P+F Sbjct: 238 LIRRMIVADPMQRITI-----QEIRRDPWF 262 >2JC6-A nrPDB Length = 334 Score = 281 bits (720), Expect = 6e-76, Method: Composition-based stats. Identities = 71/270 (26%), Positives = 128/270 (47%), Gaps = 16/270 (5%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F +G G F EV + TGK++A+KC+ KK +K K+ + ++++ Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKES-----SIENEIAVLRKIK 78 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 IV + + +P+ L ++ L++GG+L + + G ++E D +++ + ++H Sbjct: 79 HENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHR 138 Query: 311 RFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGV 366 +V+RDLKP N+L DE + ISD GL+ K + GT GY+APEVL + Sbjct: 139 MGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQ-K 197 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSFSPELRSLL 425 Y + D +S+G + + LL G+ PF +I + D S + + Sbjct: 198 PYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFI 257 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 L+++D N+R C ++ P+ Sbjct: 258 RNLMEKDPNKRYTC-----EQAARHPWIAG 282 >3DXN-A nrPDB Length = 287 Score = 281 bits (719), Expect = 7e-76, Method: Composition-based stats. Identities = 68/270 (25%), Positives = 125/270 (46%), Gaps = 15/270 (5%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + + +G G +GEV C+ TG A+K + K + L+E ++++ Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDE---VAVLKQ 77 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 D P I+ + F ++++ GG+L + FSE D +++ G ++ Sbjct: 78 LDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYL 137 Query: 309 HNRFVVYRDLKPANILLDE---HGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQK 364 H +V+RDLKP N+LL+ ++I D GL+ F K +GT Y+APEVL Sbjct: 138 HKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL-- 195 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSFSPELRS 423 YD D +S G +L+ LL G+ PF ++ + +++ + S E + Sbjct: 196 RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQ 255 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 L++ +L + ++R+ A+E P+ Sbjct: 256 LVKLMLTYEPSKRI-----SAEEALNHPWI 280 >3UC3-A nrPDB Length = 361 Score = 281 bits (719), Expect = 8e-76, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 134/303 (44%), Gaps = 19/303 (6%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + + IG G FG R T ++ A+K +++ + + +N R + Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHR-------S 72 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 P IV TP L+ I++ +GG+L+ + G FSE + RF+ +++ G+ + Sbjct: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 Query: 309 HNRFVVYRDLKPANILLDEH--GHVRISDLGLAC-DFSKKKPHASVGTHGYMAPEVLQKG 365 H+ + +RDLK N LLD ++I D G + +P ++VGT Y+APEVL + Sbjct: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQH-KTKDKHEIDRMTLTMAVELPDS--FSPELR 422 AD +S G L+ +L G PF + +D + + L++ +PD SPE Sbjct: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFF-RSLDWQMVFLQKYPPPLIPPRGEVNAAD 481 L+ + D R+ E+K +F ++L ++ P + + D Sbjct: 253 HLISRIFVADPATRISI-----PEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLD 307 Query: 482 AFD 484 Sbjct: 308 TIM 310 >3KK8-A nrPDB Length = 284 Score = 281 bits (718), Expect = 8e-76, Method: Composition-based stats. Identities = 74/273 (27%), Positives = 132/273 (48%), Gaps = 21/273 (7%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ V +G+G F V C TG +A K ++ K++ + + L RI L Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKL--- 62 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 P IV + + + DL+ GG+L + +SEAD +I+ + + Sbjct: 63 -QHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYC 121 Query: 309 HNRFVVYRDLKPANILLDEHGH---VRISDLGLACDFSKKKP-HASVGTHGYMAPEVLQK 364 H+ +V+R+LKP N+LL V+++D GLA + + + H GT GY++PEVL+K Sbjct: 122 HSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 181 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSPE 420 Y D ++ G +L+ LL G+ PF +D+H + A + P D+ +PE Sbjct: 182 D-PYSKPVDIWACGVILYILLVGYPPFWD---EDQHRLYAQIKAGAYDYPSPEWDTVTPE 237 Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 +SL++ +L + +R+ A + + P+ Sbjct: 238 AKSLIDSMLTVNPKKRI-----TADQALKVPWI 265 >2VN9-A nrPDB Length = 301 Score = 281 bits (718), Expect = 9e-76, Method: Composition-based stats. Identities = 76/274 (27%), Positives = 130/274 (47%), Gaps = 22/274 (8%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ + +G+G F V C K TG+ YA K ++ K++ + + L RI L Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL--- 60 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 P IV + + + DL+ GG+L + +SEAD +I+ + H Sbjct: 61 -KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 119 Query: 309 HNRFVVYRDLKPANILLDEHGH---VRISDLGLACDFSKKK--PHASVGTHGYMAPEVLQ 363 H +V+RDLKP N+LL V+++D GLA + + GT GY++PEVL+ Sbjct: 120 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR 179 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSP 419 K Y D ++ G +L+ LL G+ PF +D+H + + A + P D+ +P Sbjct: 180 KD-PYGKPVDMWACGVILYILLVGYPPFWD---EDQHRLYQQIKAGAYDFPSPEWDTVTP 235 Query: 420 ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 E + L+ +L + +R+ A E + P+ Sbjct: 236 EAKDLINKMLTINPAKRI-----TASEALKHPWI 264 >4D28-A nrPDB Length = 446 Score = 281 bits (718), Expect = 9e-76, Method: Composition-based stats. Identities = 98/387 (25%), Positives = 164/387 (42%), Gaps = 40/387 (10%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + V R IG G F +V R DTG A+K + K I + E ++ +V Sbjct: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR--- 67 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P IV + + K+ +L+ + GG+L + G E + R Y +++ + H H+ Sbjct: 68 HPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHS 127 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLQKGVAY 368 + V +RDLKP N+LLD +G++++SD GL+ + + + GT Y+APEVL Sbjct: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYD 187 Query: 369 DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGL 428 S+AD +S G +LF +L G+ PF D + R + P FS E++ L+ + Sbjct: 188 GSAADIWSCGVILFVILAGYLPF---SETDLPGLYRKINAAEFDCPPWFSAEVKFLIHRI 244 Query: 429 LQRDVNRRLGCLGRGAQEVKESPFFR--------------SLDWQMVFLQKYPPPLIPPR 474 L + R+ G +K+ P+FR +LD + Sbjct: 245 LDPNPKTRIQIQG-----IKKDPWFRKNYVPIRAREEEEVNLDDIRAVFDGIEGSYVAEN 299 Query: 475 GEVNAADAFDIGSFD----EEDTKGIKLLDSDQELYRNFPLTISERWQQEV---AETVFD 527 E N + +F+ + L D Q+ + +S R E+ E V + Sbjct: 300 VERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVAN 359 Query: 528 TINAET------DRLEARKKTKNKQLG 548 ++ ++ RLE K QL Sbjct: 360 SMGFKSHTRNFKTRLEGLSSIKAGQLA 386 >3HZT-A nrPDB Length = 467 Score = 280 bits (716), Expect = 1e-75, Method: Composition-based stats. Identities = 68/270 (25%), Positives = 125/270 (46%), Gaps = 15/270 (5%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + + +G G +GEV C+ TG A+K + K + L+E ++++ Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDE---VAVLKQ 60 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 D P I+ + F ++++ GG+L + FSE D +++ G ++ Sbjct: 61 LDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYL 120 Query: 309 HNRFVVYRDLKPANILLDE---HGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQK 364 H +V+RDLKP N+LL+ ++I D GL+ F K +GT Y+APEVL Sbjct: 121 HKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL-- 178 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSFSPELRS 423 YD D +S G +L+ LL G+ PF ++ + +++ + S E + Sbjct: 179 RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQ 238 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 L++ +L + ++R+ A+E P+ Sbjct: 239 LVKLMLTYEPSKRI-----SAEEALNHPWI 263 >3DFA-A nrPDB Length = 286 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 73/271 (26%), Positives = 126/271 (46%), Gaps = 16/271 (5%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ ++G+G FGEV C+ T + YA+K ++K K K T+ + L+ Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILRE----VELLKK 77 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 D P I+ + + +L GG+L + + FSE D ++ G+ +M Sbjct: 78 LDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYM 137 Query: 309 HNRFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKK-KPHASVGTHGYMAPEVLQK 364 H +V+RDLKP NILL ++ ++I D GL+ F + K +GT Y+APEVL+ Sbjct: 138 HKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG 197 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSFSPELRS 423 YD D +S G +L+ LL G PF D + ++ + + S + + Sbjct: 198 --TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKD 255 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 L+ +L + R+ A + E P+ + Sbjct: 256 LIRKMLTFHPSLRI-----TATQCLEHPWIQ 281 >4MVF-A nrPDB Length = 506 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 67/286 (23%), Positives = 127/286 (44%), Gaps = 19/286 (6%) Query: 178 KNVELNIHLTMND-FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA 236 KN+ L + D + + +G+G +G VY T ++YA+K K R+K Sbjct: 45 KNLILCHSGKLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNIN----- 99 Query: 237 LNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRF 296 + ++ D P IV + + + + I++L +G +L + ++G F+E + Sbjct: 100 -RFFQEIEIMKKLDHPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAAT 158 Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKK-PHASVG 352 +I + ++H+ +V+RDLKP N L ++ ++I D GL+ + + G Sbjct: 159 IMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAG 218 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-KHEIDRMTLTMAV 411 T Y+AP+VL YD D +S G +++ LL G+ PF + ++ + Sbjct: 219 TPYYVAPQVLDG--KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYE 276 Query: 412 ELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 S S + ++L+ LL + N R +E P+ + Sbjct: 277 NDWGSISSDAKNLITKLLTYNPNER-----CTIEEALNHPWITQMT 317 >5U6Y-A nrPDB Length = 461 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 77/274 (28%), Positives = 129/274 (47%), Gaps = 22/274 (8%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + +G+G F V C K G+ YA K ++ K++ + + L RI L Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLL----K 57 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P IV + + I DL+ GG+L + +SEAD +I+ + H H Sbjct: 58 HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 117 Query: 311 RFVVYRDLKPANILLDEHGH---VRISDLGLACDFSKKK--PHASVGTHGYMAPEVLQKG 365 VV+RDLKP N+LL V+++D GLA + ++ GT GY++PEVL+K Sbjct: 118 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD 177 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSPEL 421 Y D ++ G +L+ LL G+ PF +D+H + + A + P D+ +PE Sbjct: 178 -PYGKPVDLWACGVILYILLVGYPPFWD---EDQHRLYQQIKAGAYDFPSPEWDTVTPEA 233 Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 + L+ +L + ++R+ A E + P+ Sbjct: 234 KDLINKMLTINPSKRI-----TAAEALKHPWISH 262 >3NCG-A nrPDB Length = 486 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 74/285 (25%), Positives = 129/285 (45%), Gaps = 16/285 (5%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ ++G+G FGEV C+ T + YA+K ++K K K T+ + L+ Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILRE----VELLKK 77 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 D P I+ + + +L GG+L + + FSE D ++ G+ +M Sbjct: 78 LDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYM 137 Query: 309 HNRFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKK-KPHASVGTHGYMAPEVLQK 364 H +V+RDLKP NILL ++ ++I D GL+ F + K +GT Y+APEVL+ Sbjct: 138 HKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG 197 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSFSPELRS 423 YD D +S G +L+ LL G PF D + ++ + + S + + Sbjct: 198 --TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKD 255 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPP 468 L+ +L + R+ A + E P+ + + + P Sbjct: 256 LIRKMLTFHPSLRI-----TATQCLEHPWIQKYSSETPTISDLPS 295 >2V7O-A nrPDB Length = 336 Score = 278 bits (712), Expect = 5e-75, Method: Composition-based stats. Identities = 74/274 (27%), Positives = 132/274 (48%), Gaps = 22/274 (8%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +D+ + +G+G F V C K + YA K ++ K++ + + L RI L Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLL--- 87 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 P IV + + + DL+ GG+L + +SEAD +I+ + H+ Sbjct: 88 -KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHI 146 Query: 309 HNRFVVYRDLKPANILLDEHGH---VRISDLGLACDFSKKK--PHASVGTHGYMAPEVLQ 363 H +V+RDLKP N+LL V+++D GLA + ++ GT GY++PEVL+ Sbjct: 147 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLR 206 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSP 419 K Y D ++ G +L+ LL G+ PF +D+H++ + A + P D+ +P Sbjct: 207 KD-PYGKPVDIWACGVILYILLVGYPPFWD---EDQHKLYQQIKAGAYDFPSPEWDTVTP 262 Query: 420 ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 E ++L+ +L + +R+ A + + P+ Sbjct: 263 EAKNLINQMLTINPAKRI-----TADQALKHPWV 291 >3D2K-A nrPDB Length = 272 Score = 278 bits (711), Expect = 6e-75, Method: Composition-based stats. Identities = 73/270 (27%), Positives = 129/270 (47%), Gaps = 12/270 (4%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 T+ DF + R +G+G FG VY R+ + + A+K L K +++ E E + Sbjct: 8 QWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRRE---VE 64 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 + S P I+ + FH ++ IL+ G ++ L + F E Y E+ Sbjct: 65 IQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANA 124 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 364 L + H++ V++RD+KP N+LL +G ++I+D G + + GT Y+ PE++ + Sbjct: 125 LSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMI-E 183 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 424 G +D D +SLG + ++ L G PF H ++ + R + PD + R L Sbjct: 184 GRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETY---RRISRVEFTFPDFVTEGARDL 240 Query: 425 LEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 + LL+ + ++RL EV E P+ + Sbjct: 241 ISRLLKHNASQRLTL-----AEVLEHPWIK 265 >2VZ6-A nrPDB Length = 313 Score = 278 bits (711), Expect = 6e-75, Method: Composition-based stats. Identities = 77/274 (28%), Positives = 129/274 (47%), Gaps = 22/274 (8%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + +G+G F V C K G+ YA K ++ K++ + + L RI L Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLL----K 79 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P IV + + I DL+ GG+L + +SEAD +I+ + H H Sbjct: 80 HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 139 Query: 311 RFVVYRDLKPANILLDEHGH---VRISDLGLACDFSKKK--PHASVGTHGYMAPEVLQKG 365 VV+RDLKP N+LL V+++D GLA + ++ GT GY++PEVL+K Sbjct: 140 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD 199 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSPEL 421 Y D ++ G +L+ LL G+ PF +D+H + + A + P D+ +PE Sbjct: 200 -PYGKPVDLWACGVILYILLVGYPPFWD---EDQHRLYQQIKAGAYDFPSPEWDTVTPEA 255 Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 + L+ +L + ++R+ A E + P+ Sbjct: 256 KDLINKMLTINPSKRI-----TAAEALKHPWISH 284 >3BHH-A nrPDB Length = 295 Score = 277 bits (708), Expect = 1e-74, Method: Composition-based stats. Identities = 78/274 (28%), Positives = 132/274 (48%), Gaps = 22/274 (8%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ ++ IG+G F V C K TG YA K ++ K++ + + L RI L Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLL--- 60 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 IV + + + DL+ GG+L + +SEAD +I+ + H Sbjct: 61 -KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 119 Query: 309 HNRFVVYRDLKPANILLDEHGH---VRISDLGLACDFSKKK--PHASVGTHGYMAPEVLQ 363 H VV+RDLKP N+LL V+++D GLA + + GT GY++PEVL+ Sbjct: 120 HQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR 179 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSP 419 K AY D ++ G +L+ LL G+ PF +D+H++ + A + P D+ +P Sbjct: 180 K-EAYGKPVDIWACGVILYILLVGYPPFWD---EDQHKLYQQIKAGAYDFPSPEWDTVTP 235 Query: 420 ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 E ++L+ +L + +R+ A E + P+ Sbjct: 236 EAKNLINQMLTINPAKRI-----TAHEALKHPWV 264 >4CZT-A nrPDB Length = 464 Score = 276 bits (706), Expect = 2e-74, Method: Composition-based stats. Identities = 72/268 (26%), Positives = 129/268 (48%), Gaps = 15/268 (5%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + R +G G F +V R + G A+K +DK+++ + E + L+ Sbjct: 13 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK--- 69 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P ++ M + K+ F+L+ + GG+L +S +G E + R Y ++I +++ H+ Sbjct: 70 HPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 129 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACD----FSKKKPHASVGTHGYMAPEVLQKGV 366 R V +RDLKP N+LLD +G +++SD GL+ H + GT Y+APEV+ Sbjct: 130 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 189 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLE 426 + AD +S G +LF L+ G+ PF + + + P FS + L++ Sbjct: 190 YDGAKADLWSCGVILFVLMAGYLPFED---SNLTSLYKKIFKAEFTCPPWFSASAKKLIK 246 Query: 427 GLLQRDVNRRLGCLGRGAQEVKESPFFR 454 +L + R+ EV E+ +F+ Sbjct: 247 RILDPNPATRI-----TFAEVIENEWFK 269 >3LIJ-A nrPDB Length = 494 Score = 275 bits (704), Expect = 4e-74, Method: Composition-based stats. Identities = 76/271 (28%), Positives = 130/271 (47%), Gaps = 16/271 (5%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + +G G +GEV CR T A+K + K + L L E +L L+ D Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKL-LEEVAVLKLL---D 94 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P I+ + F +++ GG+L + F+E D +++ G+ ++H Sbjct: 95 HPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHK 154 Query: 311 RFVVYRDLKPANILL---DEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKGV 366 +V+RDLKP N+LL ++ ++I D GL+ F +KK +GT Y+APEVL Sbjct: 155 HNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL--RK 212 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-KHEIDRMTLTMAVELPDSFSPELRSLL 425 YD D +S+G +LF LL G+ PF ++ ++++ T + S + L+ Sbjct: 213 KYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLI 272 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 + +LQ D RR+ AQ+ E P+ + + Sbjct: 273 KQMLQFDSQRRI-----SAQQALEHPWIKEM 298 >2JAM-A nrPDB Length = 304 Score = 275 bits (704), Expect = 4e-74, Method: Composition-based stats. Identities = 67/282 (23%), Positives = 127/282 (45%), Gaps = 19/282 (6%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F ++G G F EV+ ++ TGK++A+KC+ K ++++ Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSS------LENEIAVLKKIK 64 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 IV + + + ++ L++GG+L + + GV++E D +++ ++++H Sbjct: 65 HENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHE 124 Query: 311 RFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVA 367 +V+RDLKP N+L +E+ + I+D GL+ + GT GY+APEVL + Sbjct: 125 NGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQ-KP 183 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSFSPELRSLLE 426 Y + D +S+G + + LL G+ PF + +I D S + + Sbjct: 184 YSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFIC 243 Query: 427 GLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPP 468 LL++D N R C ++ P+ +D + P Sbjct: 244 HLLEKDPNERYTC-----EKALSHPW---IDGNTALHRDIYP 277 >4JXF-A nrPDB Length = 266 Score = 275 bits (703), Expect = 5e-74, Method: Composition-based stats. Identities = 75/274 (27%), Positives = 130/274 (47%), Gaps = 15/274 (5%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 I + DF V ++G+G F VY TG A+K +DKK + NE + Sbjct: 2 IGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNE---V 58 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEII 302 + P I+ + F + + +L++ + G+++ +L FSE + R + +II Sbjct: 59 KIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQII 118 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPE 360 G+ ++H+ +++RDL +N+LL + +++I+D GLA +K + GT Y++PE Sbjct: 119 TGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE 178 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 + A+ +D +SLGCM + LL G PF K+ + E+P S E Sbjct: 179 -IATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLN---KVVLADYEMPSFLSIE 234 Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 + L+ LL+R+ RL V + PF Sbjct: 235 AKDLIHQLLRRNPADRLSLSS-----VLDHPFMS 263 >5YKS-A nrPDB Length = 377 Score = 274 bits (701), Expect = 8e-74, Method: Composition-based stats. Identities = 83/284 (29%), Positives = 134/284 (47%), Gaps = 17/284 (5%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + + +GRG F V R TG+ A+K +DK ++ L R M Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCM----KLVQ 92 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEHMH 309 P IV + T KL IL+L +GGD+ ++ +H +E + Y A+I+ + + H Sbjct: 93 HPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCH 152 Query: 310 NRFVVYRDLKPANI-LLDEHGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQKGVA 367 VV+RDLKP N+ ++ G V+++D G + F KK S G+ Y APE+L Sbjct: 153 KLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEY 212 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEG 427 + D +SLG +LF L+ G PF++ + M + +P S E + L+ Sbjct: 213 DAPAVDIWSLGVILFMLVCGQPPFQEANDSETLT---MIMDCKYTVPSHVSKECKDLITR 269 Query: 428 LLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLI 471 +LQRD RR +E++ P+ + +D KY PL+ Sbjct: 270 MLQRDPKRR-----ASLEEIENHPWLQGVDPSP--ATKYNIPLV 306 >4UZD-A nrPDB Length = 287 Score = 274 bits (701), Expect = 8e-74, Method: Composition-based stats. Identities = 69/272 (25%), Positives = 127/272 (46%), Gaps = 12/272 (4%) Query: 182 LNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 241 + + DF + R +G+G FG VY R+ + + A+K L K +++ E E Sbjct: 1 MKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRRE-- 58 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 + + S P I+ + FH ++ IL+ G ++ L + F E Y E+ Sbjct: 59 -VEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL 117 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEV 361 L + H++ V++RD+KP N+LL G ++I+D G + + GT Y+ PE+ Sbjct: 118 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM 177 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 + +G +D D +SLG + ++ L G PF + ++ + + + PD + Sbjct: 178 I-EGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETY---KRISRVEFTFPDFVTEGA 233 Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 R L+ LL+ + ++R +EV E P+ Sbjct: 234 RDLISRLLKHNPSQR-----PMLREVLEHPWI 260 >6C9D-A nrPDB Length = 459 Score = 273 bits (699), Expect = 1e-73, Method: Composition-based stats. Identities = 85/362 (23%), Positives = 162/362 (44%), Gaps = 17/362 (4%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 + ++ + + IG+G F +V R TG+ A+K +DK ++ + L RIM L Sbjct: 19 HIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL- 77 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + P IV + T L +++ +GG++ +L HG E + R +I+ ++ Sbjct: 78 ---NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 134 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKG 365 + H +++V+RDLK N+LLD +++I+D G + +F+ K G+ Y APE+ Q Sbjct: 135 YCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGK 194 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 D +SLG +L+ L+ G PF ++ E+ L +P S + +LL Sbjct: 195 KYDGPEVDVWSLGVILYTLVSGSLPFDG---QNLKELRERVLRGKYRIPFYMSTDCENLL 251 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDI 485 + LL + +R +++ + + ++ + L+ Y P P + D Sbjct: 252 KKLLVLNPIKR-----GSLEQIMKDRWM-NVGHEEEELKPYTEP-DPDFNDTKRIDIMVT 304 Query: 486 GSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNK 545 F ++ + E+ + L + + E E++ E D+ E K +K + Sbjct: 305 MGFARDEINDALINQKYDEVMATYILLGRKPPEFEGGESLSGEPK-ERDKEEG-KDSKPR 362 Query: 546 QL 547 L Sbjct: 363 SL 364 >4RGJ-A nrPDB Length = 520 Score = 273 bits (698), Expect = 2e-73, Method: Composition-based stats. Identities = 85/301 (28%), Positives = 133/301 (44%), Gaps = 21/301 (6%) Query: 174 FCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE 233 F Q NV N + +I+G+G FGEV R TG YA+K + KK +K K + Sbjct: 50 FIQNSNVVFN-----EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDK 104 Query: 234 TLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEAD 293 L E + L+ D I+ + F + + D+ GG+L + F E D Sbjct: 105 ESLLRE---VELLKMLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEID 161 Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLD----EHGHVRISDLGLACDF-SKKKPH 348 +I+ G+ +MH VV+RDLKP NILL+ E ++I D GL+ F KK Sbjct: 162 AARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMK 221 Query: 349 ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-KHEIDRMTL 407 +GT Y+AP+VL YD D +S G +L+ LL G PF D +++ Sbjct: 222 DKIGTAYYIAPDVLHG--TYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKY 279 Query: 408 TMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYP 467 T + S + + L++ +L R+ A++ E + + + + P Sbjct: 280 TFDLPQFKKISDKAKDLIKKMLMYTSAVRI-----SARDALEHEWIKMMTSKDNLNIDIP 334 Query: 468 P 468 Sbjct: 335 S 335 >2HAK-A nrPDB Length = 328 Score = 273 bits (697), Expect = 2e-73, Method: Composition-based stats. Identities = 77/326 (23%), Positives = 147/326 (45%), Gaps = 15/326 (4%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 + ++ + + IG+G F +V R TG+ A+K +DK ++ + L RIM L Sbjct: 13 HIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL- 71 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + P IV + T L +++ +GG++ +L HG E + R +I+ ++ Sbjct: 72 ---NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 128 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKG 365 + H +++V+RDLK N+LLD +++I+D G + +F+ K G+ Y APE+ Q Sbjct: 129 YCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGK 188 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 D +SLG +L+ L+ G PF ++ E+ L +P S + +LL Sbjct: 189 KYDGPEVDVWSLGVILYTLVSGSLPFDG---QNLKELRERVLRGKYRIPFYMSTDCENLL 245 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDI 485 + LL + +R +++ + + ++ + L+ Y P P + D Sbjct: 246 KKLLVLNPIKR-----GSLEQIMKDRWM-NVGHEEEELKPYTEP-DPDFNDTKRIDIMVT 298 Query: 486 GSFDEEDTKGIKLLDSDQELYRNFPL 511 F ++ + E+ + L Sbjct: 299 MGFARDEINDALINQKYDEVMATYIL 324 >6BXI-A nrPDB Length = 333 Score = 272 bits (696), Expect = 3e-73, Method: Composition-based stats. Identities = 97/346 (28%), Positives = 159/346 (45%), Gaps = 56/346 (16%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 L + DF ++IGRG FGEV +K DTG +YAMK L K + K+ ER Sbjct: 2 RLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERD--- 58 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 ++ D ++V M Y+F L I++ + GGD+ L + +E + +FY AE +L Sbjct: 59 ILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLA 118 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH---------------- 348 ++ +H ++RD+KP N+LLD GHV++SD GL K Sbjct: 119 IDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTF 178 Query: 349 ---------------------ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRG 387 ++VGT Y+APEV + Y+ DW+SLG +++++L G Sbjct: 179 QNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQ-TGYNKLCDWWSLGVIMYEMLIG 237 Query: 388 HSPFRQHKTKDKHEID---RMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGA 444 + PF ++ ++ + TLT E+P S + + L+ + R+G G Sbjct: 238 YPPFCSETPQETYKKVMNWKETLTFPPEVP--ISEKAKDLILRFCC-EWEHRIGA--PGV 292 Query: 445 QEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDE 490 +E+K + FF +DW+ + + P + D +FDE Sbjct: 293 EEIKSNSFFEGVDWEHIRER-------PAAISIEIKSIDDTSNFDE 331 >3SOA-A nrPDB Length = 444 Score = 272 bits (695), Expect = 4e-73, Method: Composition-based stats. Identities = 75/276 (27%), Positives = 129/276 (46%), Gaps = 22/276 (7%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 ++ + +G+G F V C K G+ YA ++ K++ + + L RI L Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLL--- 67 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 P IV + + I DL+ GG+L + +SEAD +I+ + H Sbjct: 68 -KHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 126 Query: 309 HNRFVVYRDLKPANILLDEHGH---VRISDLGLACDFSKKK--PHASVGTHGYMAPEVLQ 363 H VV+R+LKP N+LL V+++D GLA + ++ GT GY++PEVL+ Sbjct: 127 HQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 186 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP----DSFSP 419 K Y D ++ G +L+ LL G+ PF +D+H + + A + P D+ +P Sbjct: 187 KD-PYGKPVDLWACGVILYILLVGYPPFWD---EDQHRLYQQIKAGAYDFPSPEWDTVTP 242 Query: 420 ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 E + L+ +L + ++R+ A E + P+ Sbjct: 243 EAKDLINKMLTINPSKRI-----TAAEALKHPWISH 273 >3Q5I-A nrPDB Length = 504 Score = 272 bits (695), Expect = 5e-73, Method: Composition-based stats. Identities = 73/273 (26%), Positives = 126/273 (46%), Gaps = 19/273 (6%) Query: 194 HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKM-------KQGETLALNERIMLSLV 246 R +G G +GEV C++ + A+K + K + K E +SL+ Sbjct: 41 VRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLL 100 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + D P I+ + F + + GG+L + F E D +I+ G+ Sbjct: 101 KSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGIC 160 Query: 307 HMHNRFVVYRDLKPANILLDEHG---HVRISDLGLACDFSKK-KPHASVGTHGYMAPEVL 362 ++H +V+RD+KP NILL+ +++I D GL+ FSK K +GT Y+APEVL Sbjct: 161 YLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVL 220 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-KHEIDRMTLTMAVELPDSFSPEL 421 +K Y+ D +S G +++ LL G+ PF +D ++++ + S E Sbjct: 221 KK--KYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISDEA 278 Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 + L++ +L D N+R A+E S + + Sbjct: 279 KELIKLMLTYDYNKR-----CTAEEALNSRWIK 306 >5JZN-A nrPDB Length = 280 Score = 268 bits (685), Expect = 6e-72, Method: Composition-based stats. Identities = 69/282 (24%), Positives = 127/282 (45%), Gaps = 20/282 (7%) Query: 182 LNIHLTM-NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240 I T+ + V R IG G F V C + T + YA+K + K + + K+ + Sbjct: 11 FQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEH-----MIQ 65 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300 +S++ P IV + P +L +++L+ GGDL ++ ++E D Sbjct: 66 NEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYN 125 Query: 301 IILGLEHMHNRFVVYRDLKPANILL----DEHGHVRISDLGLACDFSKKKPHASVGTHGY 356 + ++++H+ +V+RD+KP N+L+ D +++ D GLA + GT Y Sbjct: 126 LASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLAT-IVDGPLYTVCGTPTY 184 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRM---TLTMAVEL 413 +APE++ + Y D ++ G + + LL G PFR + D++ + Sbjct: 185 VAPEIIAE-TGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPY 243 Query: 414 PDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 D+ S + L+ +L DV++R A +V E P+ Sbjct: 244 WDNVSDSAKELITMMLLVDVDQRF-----SAVQVLEHPWVND 280 >4YNZ-A nrPDB Length = 342 Score = 267 bits (682), Expect = 1e-71, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 138/302 (45%), Gaps = 20/302 (6%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + + +G+G G V T + A+K ++++++ E++ + ++++ + Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLS----ESVLMKVEREIAILKLIE 67 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P ++ + + L +L+ ++GG+L +L + G + + R + +II L+ H+ Sbjct: 68 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 127 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLAC-DFSKKKPHASVGTHGYMAPEVLQKGVAYD 369 + +RDLKP N+LLDE ++RI+D G+A S G+ Y PEV++ Sbjct: 128 HSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 187 Query: 370 SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLL 429 AD +S G +LF LL G PF + ++ +P P+ +SLL G++ Sbjct: 188 RKADVWSCGVILFALLVGALPFDDD---NLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMI 244 Query: 430 QRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFD 489 + D RRL + +++ ++ + + P P P +V + D Sbjct: 245 EVDAARRLTL-----EHIQKHIWY-------IGGKNEPEPEQPIPRKVQIRSLPSLEDID 292 Query: 490 EE 491 + Sbjct: 293 PD 294 >2J90-A nrPDB Length = 304 Score = 266 bits (681), Expect = 2e-71, Method: Composition-based stats. Identities = 62/277 (22%), Positives = 127/277 (45%), Gaps = 12/277 (4%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 + + + + +G G F V CR+ TGK YA K + K+R+ + +++ Sbjct: 23 MVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNI 82 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 + P I+ + F + IL+L++GG+L L++ +E + + +I+ G+ Sbjct: 83 LREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGV 142 Query: 306 EHMHNRFVVYRDLKPANILLDE----HGHVRISDLGLACDFSKKKPHASV-GTHGYMAPE 360 ++H++ + + DLKP NI+L + + +++ D G+A ++ GT ++APE Sbjct: 143 HYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPE 202 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFSP 419 ++ AD +S+G + + LL G SPF ++ I + E + S Sbjct: 203 IVNY-EPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSE 261 Query: 420 ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 + + LL +D RR+ + E + +++ Sbjct: 262 LAKDFIRRLLVKDPKRRMTI-----AQSLEHSWIKAI 293 >4CQG-A nrPDB Length = 331 Score = 266 bits (681), Expect = 2e-71, Method: Composition-based stats. Identities = 65/266 (24%), Positives = 120/266 (45%), Gaps = 16/266 (6%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + ++ IG GGF +V TG+M A+K +DK + + + + + Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSD-----LPRVKTEIDALKSLR 65 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 I + + T +K+ +L+ GG+L ++ SE + R +I+ + ++H+ Sbjct: 66 HQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHS 125 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH---ASVGTHGYMAPEVLQKGVA 367 + +RDLKP N+L DE+ +++ D GL K + G+ Y APE++Q Sbjct: 126 QGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSY 185 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEG 427 S AD +S+G +L+ L+ G PF + + + + E+P SP LL+ Sbjct: 186 LGSEADVWSMGILLYVLMCGFLPFDDD---NVMALYKKIMRGKYEVPKWLSPSSILLLQQ 242 Query: 428 LLQRDVNRRLGCLGRGAQEVKESPFF 453 +LQ D +R+ + P+ Sbjct: 243 MLQVDPKKRISMRN-----LLNHPWV 263 >4B8L-A nrPDB Length = 286 Score = 266 bits (680), Expect = 3e-71, Method: Composition-based stats. Identities = 72/270 (26%), Positives = 127/270 (47%), Gaps = 12/270 (4%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 T++DF + R +G+G FG VY R+ + A+K L K +++ + E E + Sbjct: 11 KFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRRE---IE 67 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 + S P I+ M FH ++ +L+ G+L+ L +HG F E + E+ Sbjct: 68 IQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADA 127 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 364 L + H R V++RD+KP N+L+ G ++I+D G + + GT Y+ PE++ + Sbjct: 128 LHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMI-E 186 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 424 G +D D + G + ++ L G PF + H R + + ++ P S + L Sbjct: 187 GKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETH---RRIVNVDLKFPPFLSDGSKDL 243 Query: 425 LEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 + LL+ +RL G V E P+ + Sbjct: 244 ISKLLRYHPPQRLPLKG-----VMEHPWVK 268 >4NIF-A nrPDB Length = 333 Score = 266 bits (679), Expect = 3e-71, Method: Composition-based stats. Identities = 77/279 (27%), Positives = 128/279 (45%), Gaps = 25/279 (8%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + V IG G + E C T YA+K +DK + + + L+ Sbjct: 8 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEI---------LLRY 58 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 G P I+ + + + + +LM GG+L + + FSE + F I +E++ Sbjct: 59 GQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYL 118 Query: 309 HNRFVVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKK--PHASVGTHGYMAPEVL 362 H++ VV+RDLKP+NIL +DE G+ +RI D G A + T ++APEVL Sbjct: 119 HSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL 178 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVEL----PDSFS 418 K YD D +SLG +L+ +L G++PF + EI + L ++ S Sbjct: 179 -KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVS 237 Query: 419 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 + L+ +L D ++RL A++V + P+ D Sbjct: 238 ETAKDLVSKMLHVDPHQRL-----TAKQVLQHPWVTQKD 271 >3GUB-A nrPDB Length = 295 Score = 265 bits (677), Expect = 5e-71, Method: Composition-based stats. Identities = 65/290 (22%), Positives = 127/290 (43%), Gaps = 13/290 (4%) Query: 187 TMNDF-SVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 ++D+ +G G F V CR+ TG YA K + K+R K + + +S+ Sbjct: 8 NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSI 67 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 + P ++ + + + I +L+ GG+L L++ +E + + +I+ G+ Sbjct: 68 LKEIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGV 127 Query: 306 EHMHNRFVVYRDLKPANILLDEHG----HVRISDLGLACDFSKKKPHASV-GTHGYMAPE 360 ++H+ + + DLKP NI+L + ++I D GLA ++ GT ++APE Sbjct: 128 YYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPE 187 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFSP 419 ++ AD +S+G + + LL G SPF ++ + + E + S Sbjct: 188 IVNY-EPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSA 246 Query: 420 ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPP 469 + + LL +D +R+ Q+ + P+ + D Q + P Sbjct: 247 LAKDFIRRLLVKDPKKRMTI-----QDSLQHPWIKPKDTQQALSSAWSHP 291 >4D2V-A nrPDB Length = 356 Score = 264 bits (675), Expect = 9e-71, Method: Composition-based stats. Identities = 66/266 (24%), Positives = 118/266 (44%), Gaps = 16/266 (6%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + +H IG GGF +V TG+M A+K +DK + + + + Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-----LPRIKTEIEALKNLR 85 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 I + + T +K+ +L+ GG+L ++ SE + R +I+ + ++H+ Sbjct: 86 HQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHS 145 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH---ASVGTHGYMAPEVLQKGVA 367 + +RDLKP N+L DE+ +++ D GL K + A G Y APE++Q Sbjct: 146 QGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSY 205 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEG 427 S AD +S+G +L+ L+ G PF + + ++P SP LL+ Sbjct: 206 LGSEADVWSMGILLYVLMCGFLPFDDDTAA---ALVAKIMRGKYDVPKWLSPSSILLLQQ 262 Query: 428 LLQRDVNRRLGCLGRGAQEVKESPFF 453 +LQ D +R+ + + P+ Sbjct: 263 MLQVDPKKRISM-----KNLLNHPWI 283 >2YAB-A nrPDB Length = 361 Score = 263 bits (673), Expect = 1e-70, Method: Composition-based stats. Identities = 67/281 (23%), Positives = 128/281 (45%), Gaps = 12/281 (4%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + +G G F V CR+ TG YA K + K++ + + +S++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P I+ + + + IL+L++GG+L L+Q SE + + +I+ G+ ++H Sbjct: 74 HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 311 RFVVYRDLKPANILLDEHG----HVRISDLGLACDFSKKKPHASV-GTHGYMAPEVLQKG 365 + + + DLKP NI+L + H+++ D GLA + ++ GT ++APE++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNY- 192 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFSPELRSL 424 AD +S+G + + LL G SPF ++ I ++ E S + Sbjct: 193 EPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDF 252 Query: 425 LEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQK 465 + LL ++ +RL QE P+ +D Q +++ Sbjct: 253 IRKLLVKETRKRLTI-----QEALRHPWITPVDTQQAMVRR 288 >2YCR-A nrPDB Length = 323 Score = 263 bits (672), Expect = 2e-70, Method: Composition-based stats. Identities = 75/300 (25%), Positives = 137/300 (45%), Gaps = 20/300 (6%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL--ALNERIMLSLV 246 +++ + + +G G GEV + T K A+K + K++ + ALN + ++ Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + P I+ + F D +L+LM GG+L + + EA + Y +++L ++ Sbjct: 70 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 128 Query: 307 HMHNRFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVL 362 ++H +++RDLKP N+LL +E ++I+D G + + GT Y+APEVL Sbjct: 129 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 188 Query: 363 --QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK--DKHEIDRMTLTMAVELPDSFS 418 Y+ + D +SLG +LF L G+ PF +H+T+ K +I E+ S Sbjct: 189 VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVS 248 Query: 419 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD----WQMVFLQKYPPPLIPPR 474 + L++ LL D R +E P+ + D +Q + ++ P Sbjct: 249 EKALDLVKKLLVVDPKARF-----TTEEALRHPWLQDEDMKRKFQDLLSEENESTAKPQV 303 >3COM-A nrPDB Length = 314 Score = 263 bits (671), Expect = 2e-70, Method: Composition-based stats. Identities = 61/268 (22%), Positives = 118/268 (44%), Gaps = 17/268 (6%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F V +G G +G VY +TG++ A+K + E+ +S++ D Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVP--------VESDLQEIIKEISIMQQCD 82 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADMRFYAAEIILGLEHMH 309 P +V ++ L +++ G + + ++ +E ++ + GLE++H Sbjct: 83 SPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLH 142 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVA 367 ++RD+K NILL+ GH +++D G+A + K + +GT +MAPEV+Q+ + Sbjct: 143 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-IG 201 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEG 427 Y+ AD +SLG ++ G P+ + P+ +S ++ Sbjct: 202 YNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQ 261 Query: 428 LLQRDVNRRLGCLGRGAQEVKESPFFRS 455 L + +R A ++ + PF RS Sbjct: 262 CLVKSPEQR-----ATATQLLQHPFVRS 284 >3TAC-A nrPDB Length = 361 Score = 262 bits (670), Expect = 4e-70, Method: Composition-based stats. Identities = 69/281 (24%), Positives = 119/281 (42%), Gaps = 16/281 (5%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 L + + + +IG+G F V C +TG+ +A+K +D + G + + S+ Sbjct: 23 LFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPG-LSTEDLKREASI 81 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG----VFSEADMRFYAAEI 301 P IV + + + L + + M+G DL + + + V+SEA Y +I Sbjct: 82 CHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQI 141 Query: 302 ILGLEHMHNRFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKKP--HASVGTHGY 356 + L + H+ +++RD+KP +LL + V++ G+A + VGT + Sbjct: 142 LEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHF 201 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 MAPEV+ K Y D + G +LF LL G PF K + I + M Sbjct: 202 MAPEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSH 260 Query: 417 FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 S + L+ +L D R+ E P+ + D Sbjct: 261 ISESAKDLVRRMLMLDPAERITVY-----EALNHPWLKERD 296 >2BPM-A nrPDB Length = 309 Score = 262 bits (669), Expect = 5e-70, Method: Composition-based stats. Identities = 75/313 (23%), Positives = 131/313 (41%), Gaps = 40/313 (12%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 + M +F IG G +G VY R TG++ A+K + + E + +SL Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT----ETEGVPSTAIREISL 59 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEIIL 303 + + P IV + HT +KL + + + DL + + ++ Y +++ Sbjct: 60 LKELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQ 118 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEV 361 GL H+ V++RDLKP N+L++ G ++++D GLA F + V T Y APE+ Sbjct: 119 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 178 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI--------DRMTLTMAVEL 413 L Y ++ D +SLGC+ +++ + F D+ D + + Sbjct: 179 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 238 Query: 414 PDS------------------FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 PD + RSLL +L D N+R+ A+ PFF+ Sbjct: 239 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQD 293 Query: 456 LDWQMVFLQKYPP 468 + + L+ P Sbjct: 294 VTKPVPHLRLERP 306 >2Y7J-A nrPDB Length = 365 Score = 261 bits (668), Expect = 5e-70, Method: Composition-based stats. Identities = 75/274 (27%), Positives = 124/274 (45%), Gaps = 15/274 (5%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD--KKRIKMKQGETLALNERIMLSLVST 248 + +IGRG V C TG +A+K ++ +R+ +Q E + R ++ Sbjct: 96 YDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQ 155 Query: 249 G-DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 P I+ + ++ + + + DLM G+L +L++ SE + R ++ + Sbjct: 156 VAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSF 215 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK-KPHASVGTHGYMAPEVL---- 362 +H +V+RDLKP NILLD++ +R+SD G +C K GT GY+APE+L Sbjct: 216 LHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSM 275 Query: 363 -QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAVELPDSFSPE 420 + Y D ++ G +LF LL G PF + I + D S Sbjct: 276 DETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSST 335 Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 ++ L+ LLQ D RL A++ + PFF Sbjct: 336 VKDLISRLLQVDPEARL-----TAEQALQHPFFE 364 >6FDY-U nrPDB Length = 276 Score = 261 bits (668), Expect = 6e-70, Method: Composition-based stats. Identities = 76/270 (28%), Positives = 126/270 (46%), Gaps = 14/270 (5%) Query: 188 MNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 ++ F + +G G + VY K DT ++ A+KC+ KK + E L I+ + Sbjct: 10 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGI- 68 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 P IV + D + I++ GGDL + + E R + ++ L+ Sbjct: 69 ---RHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQ 125 Query: 307 HMHNRFVVYRDLKPANILLD--EHGHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQ 363 +H R + + DLKP NILL E H++++D G A S + H G+ YMAPE++ Sbjct: 126 FLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVC 185 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 + YD+ D +S+G +L++ L G PF + E R + + L S + R Sbjct: 186 QRQ-YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRD 244 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 LL+ LL+RD +RR+ Q+ P+ Sbjct: 245 LLQRLLERDPSRRI-----SFQDFFAHPWV 269 >4C0T-A nrPDB Length = 974 Score = 261 bits (668), Expect = 6e-70, Method: Composition-based stats. Identities = 79/302 (26%), Positives = 146/302 (48%), Gaps = 23/302 (7%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 I + DF + +G G + V TGK YA+K LDK+ I ++ E+ L Sbjct: 261 IRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHAL 320 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 + +S + ++ + + F D L F+LD + G+L + ++ +E R + A+I+ Sbjct: 321 NRLS--NRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILD 378 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK-----------KPHASVG 352 +++MH+ V++RDLKP NILLD+ ++I+D G A KK + + VG Sbjct: 379 AIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVG 438 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE 412 T Y++PE+L + D ++ GC++++++ G PF K +++ + + Sbjct: 439 TAEYVSPELL-ENKYCGKPGDVWAFGCIIYQMIAGKPPF---KATNEYLTFQKITKLQFA 494 Query: 413 LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKY-PPPLI 471 F +R L++ +L +RR E+++ FF+S+D++ PP I Sbjct: 495 FSAGFPTIIRDLIKKILVLQPSRRATI-----PEIQKHYFFQSVDFKDFDSIWLSDPPEI 549 Query: 472 PP 473 P Sbjct: 550 GP 551 >4JG6-A nrPDB Length = 355 Score = 261 bits (667), Expect = 7e-70, Method: Composition-based stats. Identities = 75/288 (26%), Positives = 126/288 (43%), Gaps = 27/288 (9%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + V IG G + C T +A+K +DK + E I + L+ Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDP--------TEEIEI-LLRY 85 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 G P I+ + + + + +LM GG+L + + FSE + I +E++ Sbjct: 86 GQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYL 145 Query: 309 HNRFVVYRDLKPANIL-LDEHGH---VRISDLGLACDFSKKK--PHASVGTHGYMAPEVL 362 H + VV+RDLKP+NIL +DE G+ +RI D G A + T ++APEVL Sbjct: 146 HAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL 205 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE----LPDSFS 418 + YD++ D +SLG +L+ +L G++PF EI + +S S Sbjct: 206 -ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVS 264 Query: 419 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKY 466 + L+ +L D ++RL A V P+ + W + + Sbjct: 265 DTAKDLVSKMLHVDPHQRL-----TAALVLRHPWI--VHWDQLPQYQL 305 >3I6U-A nrPDB Length = 419 Score = 261 bits (666), Expect = 1e-69, Method: Composition-based stats. Identities = 72/279 (25%), Positives = 131/279 (46%), Gaps = 16/279 (5%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL--ALNERIMLSLV 246 +++ + + +G G GEV + T K A++ + K++ + ALN + ++ Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 + P I+ + F D +L+LM GG+L + + EA + Y +++L ++ Sbjct: 195 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 253 Query: 307 HMHNRFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVL 362 ++H +++RDLKP N+LL +E ++I+D G + + GT Y+APEVL Sbjct: 254 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 313 Query: 363 --QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK--DKHEIDRMTLTMAVELPDSFS 418 Y+ + D +SLG +LF L G+ PF +H+T+ K +I E+ S Sbjct: 314 VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVS 373 Query: 419 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 + L++ LL D R +E P+ + D Sbjct: 374 EKALDLVKKLLVVDPKARF-----TTEEALRHPWLQDED 407 >1PHK-A nrPDB Length = 298 Score = 260 bits (665), Expect = 1e-69, Method: Composition-based stats. Identities = 69/283 (24%), Positives = 118/283 (41%), Gaps = 16/283 (5%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD---KKRIKMKQGETLALNE 239 + H ++ I+GRG V C T K YA+K +D ++ + L Sbjct: 11 STHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREAT 70 Query: 240 RIMLSLVSTG-DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYA 298 + ++ P I+ + + T + DLM G+L +L++ SE + R Sbjct: 71 LKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIM 130 Query: 299 AEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK-KPHASVGTHGYM 357 ++ + +H +V+RDLKP NILLD+ +++++D G +C K GT Y+ Sbjct: 131 RALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYL 190 Query: 358 APEVLQ-----KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-KHEIDRMTLTMAV 411 APE+++ Y D +S G +++ LL G PF K I Sbjct: 191 APEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 250 Query: 412 ELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 D +S ++ L+ L +R A+E PFF+ Sbjct: 251 PEWDDYSDTVKDLVSRFLVVQPQKRY-----TAEEALAHPFFQ 288 >2W4O-A nrPDB Length = 349 Score = 260 bits (664), Expect = 2e-69, Method: Composition-based stats. Identities = 75/273 (27%), Positives = 121/273 (44%), Gaps = 24/273 (8%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F V +GRG VY C++ T K YA+K L K K R + ++ Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI--------VRTEIGVLLRLS 106 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P I+ + F TP ++S +L+L+ GG+L + + G +SE D +I+ + ++H Sbjct: 107 HPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHE 166 Query: 311 RFVVYRDLKPANILLDE---HGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGV 366 +V+RDLKP N+L ++I+D GL+ + GT GY APE+L +G Sbjct: 167 NGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEIL-RGC 225 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV----ELPDSFSPELR 422 AY D +S+G + + LL G PF + + R L D S + Sbjct: 226 AYGPEVDMWSVGIITYILLCGFEPFYDERGDQF--MFRRILNCEYYFISPWWDEVSLNAK 283 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 L+ L+ D +RL + + P+ Sbjct: 284 DLVRKLIVLDPKKRLTTF-----QALQHPWVTG 311 >6FD3-A nrPDB Length = 300 Score = 259 bits (663), Expect = 2e-69, Method: Composition-based stats. Identities = 69/266 (25%), Positives = 124/266 (46%), Gaps = 15/266 (5%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 ++ IG+G G VY TG+ A+K ++ ++ K+ L +NE ++ + Sbjct: 24 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEILV---MRENK 77 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P IV ++ D+L +++ + GG L +++ E + E + L+ +H+ Sbjct: 78 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALDFLHS 136 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH--ASVGTHGYMAPEVLQKGVAY 368 V++RD+K NILL G V+++D G + ++ VGT +MAPEV+ AY Sbjct: 137 NQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKAY 195 Query: 369 DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGL 428 D +SLG M +++ G P+ + T ++ P+ S R L Sbjct: 196 GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRC 255 Query: 429 LQRDVNRRLGCLGRGAQEVKESPFFR 454 L+ DV+RR A+E+ + PF + Sbjct: 256 LEMDVDRR-----GSAKELLQHPFLK 276 >4LG4-A nrPDB Length = 299 Score = 259 bits (661), Expect = 4e-69, Method: Composition-based stats. Identities = 56/268 (20%), Positives = 120/268 (44%), Gaps = 17/268 (6%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F V +G G +G V+ ++G++ A+K + E+ +S++ D Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVP--------VESDLQEIIKEISIMQQCD 64 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADMRFYAAEIILGLEHMH 309 P++V ++ L +++ G + + ++ E ++ + GLE++H Sbjct: 65 SPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLH 124 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVA 367 ++R++K NILL+ GH +++D G+A + K + +GT +MAPEV+Q+ + Sbjct: 125 FMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-IG 183 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEG 427 Y+ AD +SLG ++ G P+ + P+ +S + ++ Sbjct: 184 YNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKK 243 Query: 428 LLQRDVNRRLGCLGRGAQEVKESPFFRS 455 L ++ +R A ++ + PF ++ Sbjct: 244 CLVKNPEQR-----ATATQLLQHPFIKN 266 >1ZWS-A nrPDB Length = 288 Score = 258 bits (660), Expect = 5e-69, Method: Composition-based stats. Identities = 65/281 (23%), Positives = 127/281 (45%), Gaps = 12/281 (4%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + +G G F V CR+ TG YA K + K++ + + +S++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 ++ + + + IL+L++GG+L L+Q SE + + +I+ G+ ++H Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 311 RFVVYRDLKPANILLDEHG----HVRISDLGLACDFSKKKPHASV-GTHGYMAPEVLQKG 365 + + + DLKP NI+L + H+++ D GLA + ++ GT ++APE++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNY- 192 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFSPELRSL 424 AD +S+G + + LL G SPF ++ I ++ E S + Sbjct: 193 EPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFSHTSELAKDF 252 Query: 425 LEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQK 465 + LL ++ +RL QE P+ +D Q +++ Sbjct: 253 IRKLLVKETRKRLTI-----QEALRHPWITPVDNQQAMVRR 288 >2A27-A nrPDB Length = 321 Score = 258 bits (660), Expect = 5e-69, Method: Composition-based stats. Identities = 65/281 (23%), Positives = 127/281 (45%), Gaps = 12/281 (4%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + +G G F V CR+ TG YA K + K++ + + +S++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 ++ + + + IL+L++GG+L L+Q SE + + +I+ G+ ++H Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 311 RFVVYRDLKPANILLDEHG----HVRISDLGLACDFSKKKPHASV-GTHGYMAPEVLQKG 365 + + + DLKP NI+L + H+++ D GLA + ++ GT ++APE++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNY- 192 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFSPELRSL 424 AD +S+G + + LL G SPF ++ I ++ E S + Sbjct: 193 EPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDF 252 Query: 425 LEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQK 465 + LL ++ +RL QE P+ +D Q +++ Sbjct: 253 IRKLLVKETRKRLTI-----QEALRHPWITPVDNQQAMVRR 288 >5XZW-A nrPDB Length = 471 Score = 258 bits (660), Expect = 5e-69, Method: Composition-based stats. Identities = 72/281 (25%), Positives = 128/281 (45%), Gaps = 27/281 (9%) Query: 190 DFSVH-RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 DFS+ ++G+G F V + TGK +A+K + K+++ L ++ Sbjct: 196 DFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGN-----MDGVTRELEVLQK 250 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 + P IV + + + +++ ++GGDL ++ HG E R + +I+ ++++ Sbjct: 251 LNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYI 310 Query: 309 HNRFVVYRDLKPANILLDEHGH--VRISDLGLACDFSKKK-PHASVGTHGYMAPEVL--- 362 H+ + +RDLKP NIL+++ V+I+D GLA GT Y+APEV+ Sbjct: 311 HSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGK 370 Query: 363 ---------QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVE 412 ++ Y S D +S+GC+++ +L GH PF + +I R + Sbjct: 371 DTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPL 430 Query: 413 LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 S E R ++ LLQ D N R A + P+ Sbjct: 431 KDFRISEEARDFIDSLLQVDPNNR-----STAAKALNHPWI 466 >4AF3-A nrPDB Length = 292 Score = 258 bits (659), Expect = 6e-69, Method: Composition-based stats. Identities = 71/288 (24%), Positives = 134/288 (46%), Gaps = 18/288 (6%) Query: 182 LNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 241 L H T++DF + R +G+G FG VY R+ + + A+K L K +I+ + E E Sbjct: 16 LTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRRE-- 73 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 + + + P I+ + F+ ++ IL+ G+L+ L + F E E+ Sbjct: 74 -IEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEEL 132 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEV 361 L + H + V++RD+KP N+LL G ++I+D G + + GT Y+ PE+ Sbjct: 133 ADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEM 192 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 + +G ++ D + +G + ++LL G+ PF + + R + + ++ P S Sbjct: 193 I-EGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETY---RRIVKVDLKFPASVPTGA 248 Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPP 469 + L+ LL+ + + RL +V P+ R ++ PP Sbjct: 249 QDLISKLLRHNPSERLPL-----AQVSAHPWVR------ANSRRVLPP 285 >3F3Z-A nrPDB Length = 277 Score = 254 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 68/269 (25%), Positives = 117/269 (43%), Gaps = 18/269 (6%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 +++ IGRG +GEV + T A K + K + + + ++ + D Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFV------EDVDRFKQEIEIMKSLD 64 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P I+ + F + +++L GG+L + VF E+D +++ + + H Sbjct: 65 HPNIIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHK 124 Query: 311 RFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGV 366 V +RDLKP N L +++ D GLA F K VGT Y++P+VL+ Sbjct: 125 LNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEG-- 182 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFSPELRSLL 425 Y D +S G M++ LL G+ PF + +I T T + + SP+ SL+ Sbjct: 183 LYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLI 242 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 LL + +R+ L + E +F Sbjct: 243 RRLLTKSPKQRITSL-----QALEHEWFE 266 >6AO5-A nrPDB Length = 362 Score = 253 bits (647), Expect = 2e-67, Method: Composition-based stats. Identities = 56/268 (20%), Positives = 120/268 (44%), Gaps = 17/268 (6%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F V +G G +G V+ ++G++ A+K + E+ +S++ D Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVP--------VESDLQEIIKEISIMQQCD 63 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADMRFYAAEIILGLEHMH 309 P++V ++ L +++ G + + ++ E ++ + GLE++H Sbjct: 64 SPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLH 123 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVA 367 ++R++K NILL+ GH +++D G+A + K + +GT +MAPEV+Q+ + Sbjct: 124 FMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE-IG 182 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEG 427 Y+ AD +SLG ++ G P+ + P+ +S + ++ Sbjct: 183 YNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKK 242 Query: 428 LLQRDVNRRLGCLGRGAQEVKESPFFRS 455 L ++ +R A ++ + PF ++ Sbjct: 243 CLVKNPEQR-----ATATQLLQHPFIKN 265 >4AGU-A nrPDB Length = 311 Score = 253 bits (647), Expect = 2e-67, Method: Composition-based stats. Identities = 63/312 (20%), Positives = 120/312 (38%), Gaps = 39/312 (12%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 M + IG G +G V+ CR DTG++ A+K ++ + + + ++ Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKF----LESEDDPVIKKIALREIRMLK 57 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 P +V + F +L + + + LH E ++ + + + Sbjct: 58 QLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNF 117 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA--SVGTHGYMAPEVLQKG 365 H ++RD+KP NIL+ +H +++ D G A + + V T Y +PE+L Sbjct: 118 CHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGD 177 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE------------- 412 Y D +++GC+ +LL G + D+ + R TL + Sbjct: 178 TQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFS 237 Query: 413 ---LPD------------SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 +PD + S LL+G L D RL C +++ P+F ++ Sbjct: 238 GVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTC-----EQLLHHPYFENIR 292 Query: 458 WQMVFLQKYPPP 469 +++ P Sbjct: 293 EIEDLAKEHDKP 304 >3NIZ-A nrPDB Length = 311 Score = 253 bits (646), Expect = 2e-67, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 127/302 (42%), Gaps = 41/302 (13%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 M + +G G +G VY + + G++ A+K + + E + +SL+ Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLD----AEDEGIPSTAIREISLLK 74 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLE 306 P IV + H+ L+ + + M DL L ++ ++ ++ Y +++ G+ Sbjct: 75 ELHHPNIVSLIDVIHSERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGVA 133 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQK 364 H H +++RDLKP N+L++ G ++++D GLA F + V T Y AP+VL Sbjct: 134 HCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMG 193 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV--------ELP-- 414 Y +S D +S+GC+ +++ G F D+ L ELP Sbjct: 194 SKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLW 253 Query: 415 -----------------DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 F E LL +L D N+R+ A++ P+F+ LD Sbjct: 254 KQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRI-----SARDAMNHPYFKDLD 308 Query: 458 WQ 459 Q Sbjct: 309 PQ 310 >4I6B-A nrPDB Length = 308 Score = 253 bits (646), Expect = 2e-67, Method: Composition-based stats. Identities = 59/275 (21%), Positives = 121/275 (44%), Gaps = 15/275 (5%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 +S + +G+GGF + Y K+YA K + R+ E + ++ Sbjct: 29 RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILH-- 86 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 +V + F + + +L+ + + + L V +E ++R+Y +I+ GL+++H Sbjct: 87 -HKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLH 145 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK--KKPHASVGTHGYMAPEVLQKGVA 367 + +++RDLK N ++E +++ D GLA + GT Y++PEVL K Sbjct: 146 EQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNK-QG 204 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEG 427 + + +D ++LGC+++ +L G PF K+ + R +P S + L+ Sbjct: 205 HGAESDIWALGCVMYTMLLGRPPFETTNLKETY---RSIREARYTMPSSLLAPAKHLIAS 261 Query: 428 LLQRDVNRRLGCLGRGAQEVKESPFF-RSLDWQMV 461 +L ++ R ++ FF + + Sbjct: 262 MLSKNPEDR-----PSLDDIIRHDFFTQGFTPDRL 291 >3DB8-A nrPDB Length = 317 Score = 251 bits (641), Expect = 7e-67, Method: Composition-based stats. Identities = 72/273 (26%), Positives = 124/273 (45%), Gaps = 14/273 (5%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 TM + R +G+GGF + Y DT +++A K + K + + E ++ Sbjct: 38 PRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTE---IA 94 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 + + D P +V F D + +L++ L + +E + R++ + I G Sbjct: 95 IHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQG 154 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC--DFSKKKPHASVGTHGYMAPEVL 362 ++++HN V++RDLK N+ L++ V+I D GLA +F ++ GT Y+APEVL Sbjct: 155 VQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVL 214 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 K + D +SLGC+L+ LL G PF K+ + + +P +P Sbjct: 215 CK-KGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKN---EYSVPRHINPVAS 270 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 +L+ +L D R E+ FF S Sbjct: 271 ALIRRMLHADPTLR-----PSVAELLTDEFFTS 298 >4QMW-A nrPDB Length = 310 Score = 251 bits (641), Expect = 8e-67, Method: Composition-based stats. Identities = 75/265 (28%), Positives = 133/265 (50%), Gaps = 16/265 (6%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F+ IG+G FGEV+ T K+ A+K +D +++ E + + ++++S D Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIID-----LEEAEDEIEDIQQEITVLSQCD 85 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P++ ++ KL I++ + GG L + G E + EI+ GL+++H+ Sbjct: 86 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLL-EPGPLDETQIATILREILKGLDYLHS 144 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVAY 368 ++RD+K AN+LL EHG V+++D G+A + K + VGT +MAPEV+++ AY Sbjct: 145 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AY 203 Query: 369 DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGL 428 DS AD +SLG +L RG P + + +E ++S L+ +E Sbjct: 204 DSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLE--GNYSKPLKEFVEAC 261 Query: 429 LQRDVNRRLGCLGRGAQEVKESPFF 453 L ++ + R A+E+ + F Sbjct: 262 LNKEPSFR-----PTAKELLKHKFI 281 >4PDS-A nrPDB Length = 347 Score = 251 bits (641), Expect = 9e-67, Method: Composition-based stats. Identities = 70/282 (24%), Positives = 128/282 (45%), Gaps = 27/282 (9%) Query: 190 DFSVH-RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 DFS+ ++G+G F V + TGK +++K + K+++ L ++ Sbjct: 31 DFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGN-----MDGVTRELEVLQK 85 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 + P IV + + + +++ ++GGDL ++ HG E R + +I+ ++++ Sbjct: 86 LNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYI 145 Query: 309 HNRFVVYRDLKPANILLDEHGH--VRISDLGLACDFSKKK-PHASVGTHGYMAPEVL--- 362 H+ + +RDLKP NIL+++ V+I+ GLA GT Y+APEV+ Sbjct: 146 HSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGK 205 Query: 363 ---------QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVE 412 ++ Y S D +S+GC+++ +L GH PF + +I R + Sbjct: 206 DTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPL 265 Query: 413 LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 S E R ++ LLQ D N R A + P+ + Sbjct: 266 KDFRISEEARDFIDSLLQVDPNNR-----STAAKALNHPWIK 302 >3DAK-A nrPDB Length = 290 Score = 251 bits (640), Expect = 1e-66, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 127/296 (42%), Gaps = 32/296 (10%) Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240 L + +D+ + +IG G V A + A+K ++ ++ + E L Sbjct: 2 ALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLK---- 57 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL--------SQHGVFSEA 292 + +S P IV +F D+L ++ L++GG + + + GV E+ Sbjct: 58 -EIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDES 116 Query: 293 DMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP----- 347 + E++ GLE++H ++RD+K NILL E G V+I+D G++ + Sbjct: 117 TIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNK 176 Query: 348 --HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRM 405 VGT +MAPEV+++ YD AD +S G +L G +P+ ++ + Sbjct: 177 VRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQ 236 Query: 406 TLTMAV-------ELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 ++ E+ + R ++ LQ+D +R A E+ FF+ Sbjct: 237 NDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKR-----PTAAELLRHKFFQ 287 >4B6L-A nrPDB Length = 281 Score = 251 bits (640), Expect = 1e-66, Method: Composition-based stats. Identities = 76/265 (28%), Positives = 120/265 (45%), Gaps = 14/265 (5%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + R++G+GGF Y +TG YA+K + + R+ LNE + L Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNE---IELHRDLQ 67 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 IV S+ F D + L+L + L + E ++R+Y +I+ GL+++H Sbjct: 68 HRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQ 127 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSK--KKPHASVGTHGYMAPEVLQKGVAY 368 R +++RDLK N + E+ +++ D GLA ++ GT Y+APEVL + Sbjct: 128 RGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGH 186 Query: 369 DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGL 428 AD +SLGC+++ LL G PF T D E R + LP S S R LL + Sbjct: 187 GPEADVWSLGCVMYTLLCGSPPFE---TADLKETYRCIKQVHYTLPASLSLPARQLLAAI 243 Query: 429 LQRDVNRRLGCLGRGAQEVKESPFF 453 L+ R ++ FF Sbjct: 244 LRASPRDR-----PSIDQILRHDFF 263 >2F57-A nrPDB Length = 317 Score = 251 bits (640), Expect = 1e-66, Method: Composition-based stats. Identities = 72/261 (27%), Positives = 125/261 (47%), Gaps = 15/261 (5%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 IG G G V + TGK A+K +D ++ +Q L NE +++ +V Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMD---LRKQQRRELLFNEVVIMRDYH---HDNVV 105 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 M ++ D+L +++ + GG L + H +E + ++ L ++HN+ V++ Sbjct: 106 DMYSSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIATVCLSVLRALSYLHNQGVIH 164 Query: 316 RDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVAYDSSAD 373 RD+K +ILL G +++SD G SK+ K + VGT +MAPEV+ + Y + D Sbjct: 165 RDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS-RLPYGTEVD 223 Query: 374 WFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDV 433 +SLG M+ +++ G P+ R +L V+ S LR L+ +L R+ Sbjct: 224 IWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREP 283 Query: 434 NRRLGCLGRGAQEVKESPFFR 454 ++R AQE+ PF + Sbjct: 284 SQR-----ATAQELLGHPFLK 299 >3Q53-A nrPDB Length = 306 Score = 250 bits (639), Expect = 1e-66, Method: Composition-based stats. Identities = 67/266 (25%), Positives = 122/266 (45%), Gaps = 15/266 (5%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 ++ IG+G G VY TG+ A++ ++ ++ K+ L +NE ++ + Sbjct: 23 YTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKE---LIINEILV---MRENK 76 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P IV ++ D+L +++ + GG L +++ E + E + LE +H+ Sbjct: 77 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTE-TCMDEGQIAAVCRECLQALEFLHS 135 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH--ASVGTHGYMAPEVLQKGVAY 368 V++RD+K NILL G V+++D G + ++ VGT +MAPEV+ AY Sbjct: 136 NQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKAY 194 Query: 369 DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGL 428 D +SLG M +++ G P+ + T ++ P+ S R L Sbjct: 195 GPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRC 254 Query: 429 LQRDVNRRLGCLGRGAQEVKESPFFR 454 L+ DV +R A+E+ + F + Sbjct: 255 LEMDVEKR-----GSAKELIQHQFLK 275 >6CMJ-A nrPDB Length = 321 Score = 250 bits (639), Expect = 1e-66, Method: Composition-based stats. Identities = 70/281 (24%), Positives = 134/281 (47%), Gaps = 22/281 (7%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK-----QGETLALNER 240 + ++ +++ IG+G +G V + YAMK L KK++ + Q Sbjct: 31 VQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVY 90 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYA 298 ++++ D P +V + P D L + +L+N G + + SE RFY Sbjct: 91 QEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARFYF 149 Query: 299 AEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK--PHASVGTHGY 356 ++I G+E++H + +++RD+KP+N+L+ E GH++I+D G++ +F +VGT + Sbjct: 150 QDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAF 209 Query: 357 MAPEVLQKGVAY--DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP 414 MAPE L + + D +++G L+ + G PF + H + A+E P Sbjct: 210 MAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS---KIKSQALEFP 266 Query: 415 D--SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 D + +L+ L+ +L ++ R+ E+K P+ Sbjct: 267 DQPDIAEDLKDLITRMLDKNPESRI-----VVPEIKLHPWV 302 >3KN6-A nrPDB Length = 325 Score = 250 bits (639), Expect = 1e-66, Method: Composition-based stats. Identities = 73/268 (27%), Positives = 120/268 (44%), Gaps = 22/268 (8%) Query: 195 RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 254 + +G G F C + + +A+K + K+ Q E AL P I Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKL--------CEGHPNI 68 Query: 255 VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVV 314 V + FH +++L+NGG+L + + FSE + + +++ + HMH+ VV Sbjct: 69 VKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVV 128 Query: 315 YRDLKPANILL---DEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVAYD 369 +RDLKP N+L +++ ++I D G A T Y APE+L + YD Sbjct: 129 HRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQN-GYD 187 Query: 370 SSADWFSLGCMLFKLLRGHSPFRQHK--------TKDKHEIDRMTLTMAVELPDSFSPEL 421 S D +SLG +L+ +L G PF+ H + +I + + E + S E Sbjct: 188 ESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEA 247 Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQEVKE 449 + L++GLL D N+RL G E + Sbjct: 248 KDLIQGLLTVDPNKRLKMSGLRYNEWLQ 275 >4CSV-A nrPDB Length = 275 Score = 249 bits (635), Expect = 4e-66, Method: Composition-based stats. Identities = 47/260 (18%), Positives = 107/260 (41%), Gaps = 16/260 (6%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 + ++ ++ R +G G FGEVY + + A+K L + + +++ Sbjct: 5 KWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEF-------LQE 57 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSE--ADMRFYAAE 300 ++ P +V + + I + M+ G L +L + + AA+ Sbjct: 58 AQIMKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQ 117 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG---THGYM 357 + G+ ++ ++ ++RDL N L+ E+ V+++D GLA ++ + A G + Sbjct: 118 VASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWT 177 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 APE + + +D ++ G +L+++ G P+ + I+++ + P Sbjct: 178 APEAISYNR-FSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEV--IEQVERGYRMPRPQG 234 Query: 417 FSPELRSLLEGLLQRDVNRR 436 E+ L+ + R Sbjct: 235 CPEEIYELMLQCWNKSPEER 254 >4KS7-A nrPDB Length = 292 Score = 248 bits (634), Expect = 5e-66, Method: Composition-based stats. Identities = 73/279 (26%), Positives = 128/279 (45%), Gaps = 23/279 (8%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 IG G G V R+ +G+ A+K +D ++ +Q L NE +++ +V Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMD---LRKQQRRELLFNEVVIMRDYQHF---NVV 83 Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 M ++ ++L +++ + GG L + +E + ++ L ++H + V++ Sbjct: 84 EMYKSYLVGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIH 142 Query: 316 RDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVAYDSSAD 373 RD+K +ILL G V++SD G SK K + VGT +MAPEV+ + + Y + D Sbjct: 143 RDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL-YATEVD 201 Query: 374 WFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDV 433 +SLG M+ +++ G P+ + R + ++ SP LR LE +L RD Sbjct: 202 IWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDP 261 Query: 434 NRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 472 R AQE+ + PF + P L+P Sbjct: 262 QER-----ATAQELLDHPF--------LLQTGLPECLVP 287 >2UV2-A nrPDB Length = 325 Score = 247 bits (632), Expect = 8e-66, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 135/295 (45%), Gaps = 21/295 (7%) Query: 167 ESDKFTRFCQWKNVELNIHLTMNDF-SVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK 225 E+ F Q+++V + L DF + +G G FG+VY + +T + A K +D K Sbjct: 16 ENLYFQSMKQYEHVTRD--LNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTK 73 Query: 226 RIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHY-HLS 284 E + + + ++++ D P IV + AF+ + L +++ GG + L Sbjct: 74 ------SEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLE 127 Query: 285 QHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK 344 +E+ ++ + + L ++H+ +++RDLK NIL G ++++D G++ ++ Sbjct: 128 LERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTR 187 Query: 345 --KKPHASVGTHGYMAPEVLQ----KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 ++ + +GT +MAPEV+ K YD AD +SLG L ++ P + Sbjct: 188 TIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMR 247 Query: 399 KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 + + P +S + L+ L+++V+ R ++ + PF Sbjct: 248 VLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDAR-----WTTSQLLQHPFV 297 >3IS5-A nrPDB Length = 285 Score = 247 bits (631), Expect = 1e-65, Method: Composition-based stats. Identities = 73/283 (25%), Positives = 131/283 (46%), Gaps = 23/283 (8%) Query: 182 LNIHLTMND-FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240 L T++D F R +G G FG+V+ + +G +K ++K R ++ + A Sbjct: 14 LYFQGTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEA---- 69 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS----QHGVFSEADMRF 296 + ++ + D P I+ + F + +++ GG+L + + SE + Sbjct: 70 -EIEVLKSLDHPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAE 128 Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDE---HGHVRISDLGLACDF-SKKKPHASVG 352 +++ L + H++ VV++DLKP NIL + H ++I D GLA F S + + G Sbjct: 129 LMKQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAG 188 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDR-MTLTMAV 411 T YMAPEV ++ V + D +S G +++ LL G PF ++ + AV Sbjct: 189 TALYMAPEVFKRDVTF--KCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAV 246 Query: 412 ELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 E +P+ LL+ +L +D RR A +V +F+ Sbjct: 247 EC-RPLTPQAVDLLKQMLTKDPERR-----PSAAQVLHHEWFK 283 >2HW6-A nrPDB Length = 307 Score = 247 bits (631), Expect = 1e-65, Method: Composition-based stats. Identities = 68/293 (23%), Positives = 121/293 (41%), Gaps = 42/293 (14%) Query: 195 RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 254 ++G G + +V G GK YA+K ++K+ + R + +L I Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVF-----REVETLYQCQGNKNI 73 Query: 255 VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVV 314 + + F + + + + GG + H+ + F+E + ++ L+ +H + + Sbjct: 74 LELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIA 133 Query: 315 YRDLKPANILLDEH---GHVRISDLGL---------ACDFSKKKPHASVGTHGYMAPEVL 362 +RDLKP NIL + V+I D L + + G+ YMAPEV+ Sbjct: 134 HRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVV 193 Query: 363 Q----KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD------------KHEIDRMT 406 + + YD D +SLG +L+ +L G+ PF H D ++++ Sbjct: 194 EVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESI 253 Query: 407 LTMAVELPD----SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 E PD S E + L+ LL RD +RL A +V + P+ + Sbjct: 254 QEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRL-----SAAQVLQHPWVQG 301 >2Q0N-A nrPDB Length = 301 Score = 246 bits (629), Expect = 2e-65, Method: Composition-based stats. Identities = 71/267 (26%), Positives = 127/267 (47%), Gaps = 18/267 (6%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 +++F IG G G V +GK+ A+K +D ++ +Q L NE + ++ Sbjct: 31 LDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVV---IMR 81 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 +V M ++ D+L +++ + GG L + H +E + ++ L Sbjct: 82 DYQHENVVEMYNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSV 140 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH--ASVGTHGYMAPEVLQKG 365 +H + V++RD+K +ILL G V++SD G SK+ P + VGT +MAPE++ + Sbjct: 141 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISR- 199 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 + Y D +SLG M+ +++ G P+ ++ R L ++ SP L+ L Sbjct: 200 LPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFL 259 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPF 452 + LL RD +R A E+ + PF Sbjct: 260 DRLLVRDPAQR-----ATAAELLKHPF 281 >4JDH-A nrPDB Length = 346 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 71/267 (26%), Positives = 127/267 (47%), Gaps = 18/267 (6%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 +++F IG G G V +GK+ A+K +D ++ +Q L NE + ++ Sbjct: 76 LDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVV---IMR 126 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 +V M ++ D+L +++ + GG L + H +E + ++ L Sbjct: 127 DYQHENVVEMYNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSV 185 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH--ASVGTHGYMAPEVLQKG 365 +H + V++RD+K +ILL G V++SD G SK+ P + VGT +MAPE++ + Sbjct: 186 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISR- 244 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 + Y D +SLG M+ +++ G P+ ++ R L ++ SP L+ L Sbjct: 245 LPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFL 304 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPF 452 + LL RD +R A E+ + PF Sbjct: 305 DRLLVRDPAQR-----ATAAELLKHPF 326 >2WQN-A nrPDB Length = 310 Score = 246 bits (627), Expect = 3e-65, Method: Composition-based stats. Identities = 82/294 (27%), Positives = 140/294 (47%), Gaps = 19/294 (6%) Query: 150 IEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCR 209 ++E Q ++G +F ++ N T+ +F + + IGRG F EVY Sbjct: 1 MDEQSQGMQGPPVPQFQPQKALR-----PDMGYN---TLANFRIEKKIGRGQFSEVYRAA 52 Query: 210 KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSF 269 G A+K + + + + E + L+ + P ++ +F ++L+ Sbjct: 53 CLLDGVPVALKKVQIFDLMDAKARADCIKE---IDLLKQLNHPNVIKYYASFIEDNELNI 109 Query: 270 ILDLMNGGDLHYHLS----QHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL 325 +L+L + GDL + Q + E + Y ++ LEHMH+R V++RD+KPAN+ + Sbjct: 110 VLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFI 169 Query: 326 DEHGHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFK 383 G V++ DLGL FS K H+ VGT YM+PE + + Y+ +D +SLGC+L++ Sbjct: 170 TATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHEN-GYNFKSDIWSLGCLLYE 228 Query: 384 LLRGHSPFRQHKTKDKHEIDRMTLTMAVELP-DSFSPELRSLLEGLLQRDVNRR 436 + SPF K ++ LP D +S ELR L+ + D +R Sbjct: 229 MAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKR 282 >5YV8-A nrPDB Length = 298 Score = 246 bits (627), Expect = 3e-65, Method: Composition-based stats. Identities = 71/296 (23%), Positives = 134/296 (45%), Gaps = 37/296 (12%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK--------------- 230 + +N +++ IG+G +G V + YAMK L KK++ + Sbjct: 10 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 69 Query: 231 -----QGETLALNERIMLSLVSTGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHL 283 Q ++++ D P +V + P D L + +L+N G + + Sbjct: 70 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-V 128 Query: 284 SQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS 343 SE RFY ++I G+E++H + +++RD+KP+N+L+ E GH++I+D G++ +F Sbjct: 129 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 188 Query: 344 KKK--PHASVGTHGYMAPEVLQKGVAY--DSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 399 +VGT +MAPE L + + D +++G L+ + G PF + Sbjct: 189 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 248 Query: 400 HEIDRMTLTMAVELPD--SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 H + A+E PD + +L+ L+ +L ++ R+ E+K P+ Sbjct: 249 HS---KIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRI-----VVPEIKLHPWV 296 >4XBR-A nrPDB Length = 366 Score = 246 bits (627), Expect = 4e-65, Method: Composition-based stats. Identities = 71/267 (26%), Positives = 127/267 (47%), Gaps = 18/267 (6%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 +++F IG G G V +GK+ A+K +D ++ +Q L NE + ++ Sbjct: 96 LDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVV---IMR 146 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 +V M ++ D+L +++ + GG L + H +E + ++ L Sbjct: 147 DYQHENVVEMYNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSV 205 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH--ASVGTHGYMAPEVLQKG 365 +H + V++RD+K +ILL G V++SD G SK+ P + VGT +MAPE++ + Sbjct: 206 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISR- 264 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 + Y D +SLG M+ +++ G P+ ++ R L ++ SP L+ L Sbjct: 265 LPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFL 324 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPF 452 + LL RD +R A E+ + PF Sbjct: 325 DRLLVRDPAQR-----ATAAELLKHPF 346 >2OU7-A nrPDB Length = 335 Score = 246 bits (627), Expect = 4e-65, Method: Composition-based stats. Identities = 70/261 (26%), Positives = 120/261 (45%), Gaps = 14/261 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G+GGF + + ADT +++A K + K + E +S+ + +V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSME---ISIHRSLAHQHVVG 105 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 F D + +L+L L + +E + R+Y +I+LG +++H V++R Sbjct: 106 FHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 165 Query: 317 DLKPANILLDEHGHVRISDLGLAC--DFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADW 374 DLK N+ L+E V+I D GLA ++ ++ GT Y+APEVL K + D Sbjct: 166 DLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSK-KGHSFEVDV 224 Query: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVN 434 +S+GC+++ LL G PF K+ + + +P +P SL++ +LQ D Sbjct: 225 WSIGCIMYTLLVGKPPFETSCLKETYLRIKKN---EYSIPKHINPVAASLIQKMLQTDPT 281 Query: 435 RRLGCLGRGAQEVKESPFFRS 455 R E+ FF S Sbjct: 282 AR-----PTINELLNDEFFTS 297 >2XIK-A nrPDB Length = 294 Score = 245 bits (626), Expect = 4e-65, Method: Composition-based stats. Identities = 78/281 (27%), Positives = 133/281 (47%), Gaps = 22/281 (7%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F+ IG+G FGEVY T ++ A+K +D +++ E + + ++++S D Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIID-----LEEAEDEIEDIQQEITVLSQCD 75 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P+I ++ KL I++ + GG L + G E + EI+ GL+++H+ Sbjct: 76 SPYITRYFGSYLKSTKLWIIMEYLGGGSALDLL-KPGPLEETYIATILREILKGLDYLHS 134 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVAY 368 ++RD+K AN+LL E G V+++D G+A + K + VGT +MAPEV+++ AY Sbjct: 135 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AY 193 Query: 369 DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP---DSFSPELRSLL 425 D AD +SLG +L +G P D H + + L P S + + Sbjct: 194 DFKADIWSLGITAIELAKGEPP-----NSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFV 248 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKY 466 E L +D R A+E+ + F + FL + Sbjct: 249 EACLNKDPRFR-----PTAKELLKHKFITRYTKKTSFLTEL 284 >4FZF-B nrPDB Length = 283 Score = 245 bits (626), Expect = 5e-65, Method: Composition-based stats. Identities = 74/268 (27%), Positives = 130/268 (48%), Gaps = 22/268 (8%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F+ IG+G FGEV+ T ++ A+K +D +++ E + + ++++S D Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIID-----LEEAEDEIEDIQQEITVLSQCD 64 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 ++ ++ KL I++ + GG L G F E + EI+ GL+++H+ Sbjct: 65 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHS 123 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVLQKGVAY 368 ++RD+K AN+LL E G V+++ G+A + K + VGT +MAPEV+Q+ AY Sbjct: 124 EKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQS-AY 182 Query: 369 DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP---DSFSPELRSLL 425 DS AD +SLG +L +G P D H + + L P F+ + + Sbjct: 183 DSKADIWSLGITAIELAKGEPP-----NSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFI 237 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFF 453 + L +D + R A+E+ + F Sbjct: 238 DACLNKDPSFR-----PTAKELLKHKFI 260 >4FIE-A nrPDB Length = 423 Score = 245 bits (625), Expect = 5e-65, Method: Composition-based stats. Identities = 71/267 (26%), Positives = 127/267 (47%), Gaps = 18/267 (6%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 +++F IG G G V +GK+ A+K +D ++ +Q L NE + ++ Sbjct: 153 LDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVV---IMR 203 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 +V M ++ D+L +++ + GG L + H +E + ++ L Sbjct: 204 DYQHENVVEMYNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSV 262 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH--ASVGTHGYMAPEVLQKG 365 +H + V++RD+K +ILL G V++SD G SK+ P + VGT +MAPE++ + Sbjct: 263 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISR- 321 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 + Y D +SLG M+ +++ G P+ ++ R L ++ SP L+ L Sbjct: 322 LPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFL 381 Query: 426 EGLLQRDVNRRLGCLGRGAQEVKESPF 452 + LL RD +R A E+ + PF Sbjct: 382 DRLLVRDPAQR-----ATAAELLKHPF 403 >4J52-A nrPDB Length = 293 Score = 245 bits (625), Expect = 6e-65, Method: Composition-based stats. Identities = 70/261 (26%), Positives = 120/261 (45%), Gaps = 14/261 (5%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G+GGF + + ADT +++A K + K + E +S+ + +V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSME---ISIHRSLAHQHVVG 78 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 F D + +L+L L + +E + R+Y +I+LG +++H V++R Sbjct: 79 FHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 138 Query: 317 DLKPANILLDEHGHVRISDLGLAC--DFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADW 374 DLK N+ L+E V+I D GLA ++ ++ GT Y+APEVL K + D Sbjct: 139 DLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSK-KGHSFEVDV 197 Query: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVN 434 +S+GC+++ LL G PF K+ + + +P +P SL++ +LQ D Sbjct: 198 WSIGCIMYTLLVGKPPFETSCLKETYLRIKKN---EYSIPKHINPVAASLIQKMLQTDPT 254 Query: 435 RRLGCLGRGAQEVKESPFFRS 455 R E+ FF S Sbjct: 255 AR-----PTINELLNDEFFTS 270 >3UTO-A nrPDB Length = 573 Score = 245 bits (625), Expect = 6e-65, Method: Composition-based stats. Identities = 87/378 (23%), Positives = 144/378 (38%), Gaps = 46/378 (12%) Query: 174 FCQWKN-----VELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIK 228 F WK VE+ ++ + +H +G G FG V+ + TG +A K + Sbjct: 137 FDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV------ 190 Query: 229 MKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL-SQHG 287 M E+ R + +S P +V + AF +++ I + M+GG+L + +H Sbjct: 191 MTPHESDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHN 250 Query: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDE--HGHVRISDLGLACDFSKK 345 SE + Y ++ GL HMH V+ DLKP NI+ +++ D GL K Sbjct: 251 KMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPK 310 Query: 346 KP-HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEID 403 + + GT + APEV +G D +S+G + + LL G SPF + + Sbjct: 311 QSVKVTTGTAEFAAPEV-AEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVK 369 Query: 404 RMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF---------- 453 M S + + + LL D N R+ + E P+ Sbjct: 370 SCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIH-----QALEHPWLTPGNAPGRDS 424 Query: 454 --------RSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQEL 505 + D +P PL PP G ++ + E + S+ + Sbjct: 425 QIPSSRYTKIRDSIKTKYDAWPEPL-PPLGRISNYSSLRKHRPQEYSIRDAFWDRSEAQ- 482 Query: 506 YRNFPLTISERWQQEVAE 523 P I + + EV E Sbjct: 483 ----PRFIVKPYGTEVGE 496 >3FXW-A nrPDB Length = 336 Score = 244 bits (623), Expect = 1e-64, Method: Composition-based stats. Identities = 65/289 (22%), Positives = 117/289 (40%), Gaps = 31/289 (10%) Query: 180 VELNIHLTMNDFSVHR-IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALN 238 E + +D+ + + ++G G G+V C TG+ A+K L ++ + Sbjct: 19 PEPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHW-- 76 Query: 239 ERIMLSLVSTGDCPFIVCMSYAFHT----PDKLSFILDLMNGGDLHYHLSQHG--VFSEA 292 P IVC+ + L I++ M GG+L + + G F+E Sbjct: 77 --------QASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTER 128 Query: 293 DMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD---EHGHVRISDLGLACDFSKKKPHA 349 + +I ++ +H+ + +RD+KP N+L + ++++D G A + ++ Sbjct: 129 EAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQT 188 Query: 350 SVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-----KHEIDR 404 T Y+APEVL YD S D +SLG +++ LL G PF + + K I Sbjct: 189 PCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRL 247 Query: 405 MTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 S + + L+ LL+ D RL + P+ Sbjct: 248 GQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTIT-----QFMNHPWI 291 >6QAU-A nrPDB Length = 280 Score = 244 bits (622), Expect = 1e-64, Method: Composition-based stats. Identities = 73/276 (26%), Positives = 125/276 (45%), Gaps = 22/276 (7%) Query: 190 DFSVHRIIGRGGFGEVYGCRKA-DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 ++S ++G G F V+ R T A+K ++KK + Q + + ++ Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ-----ILLGKEIKILKE 66 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 IV + P+ + +++ NGGDL +L G SE +R + +I + + Sbjct: 67 LQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRIL 126 Query: 309 HNRFVVYRDLKPANILLDEHG---------HVRISDLGLACDFSKKKPHAS-VGTHGYMA 358 H++ +++RDLKP NILL ++I+D G A A G+ YMA Sbjct: 127 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMA 186 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS 418 PEV+ YD+ AD +S+G ++++ L G PF+ + +D ++ +P S Sbjct: 187 PEVIM-SQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 245 Query: 419 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 P L +LL GLLQR+ R+ + PF Sbjct: 246 PYLANLLLGLLQRNQKDRM-----DFEAFFSHPFLE 276 >5D7A-A nrPDB Length = 308 Score = 243 bits (621), Expect = 2e-64, Method: Composition-based stats. Identities = 68/283 (24%), Positives = 121/283 (42%), Gaps = 34/283 (12%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F + ++G G +G+VY R TG++ A+K +D E E ML S Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMD----VTGDEEEEIKQEINMLKKYSH-- 72 Query: 251 CPFIVCMSYAFHT------PDKLSFILDLMNGGDLHYHLS--QHGVFSEADMRFYAAEII 302 I AF D+L +++ G + + + E + + EI+ Sbjct: 73 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 132 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK--KKPHASVGTHGYMAPE 360 GL H+H V++RD+K N+LL E+ V++ D G++ + + + +GT +MAPE Sbjct: 133 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 192 Query: 361 VL----QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP-- 414 V+ YD +D +SLG ++ G P D H + + L P Sbjct: 193 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLC-----DMHPMRALFLIPRNPAPRL 247 Query: 415 --DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 +S + +S +E L ++ ++R +++ + PF R Sbjct: 248 KSKKWSKKFQSFIESCLVKNHSQR-----PATEQLMKHPFIRD 285 >5J5T-A nrPDB Length = 370 Score = 243 bits (620), Expect = 2e-64, Method: Composition-based stats. Identities = 71/308 (23%), Positives = 141/308 (45%), Gaps = 17/308 (5%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 + DF + + IG G +G+VY R +TG++ A+K + K++ GE A+ + + ++ Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVI-----KLEPGEDFAV-VQQEIIMM 55 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 P IV ++ DKL ++ GG L G SE + + + E + GL Sbjct: 56 KDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 115 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEV--L 362 ++H++ ++RD+K ANILL ++GHV+++D G++ + K A +GT +MAPEV + Sbjct: 116 YLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAV 175 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSP-FRQHKTKDKHEIDRMTL-TMAVELPDSFSPE 420 ++ Y+ D +++G +L P F H + + + ++ +S Sbjct: 176 ERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNS 235 Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480 ++ L ++ +R A+++ + PF + + ++ P + Sbjct: 236 FHHFVKMALTKNPKKR-----PTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDF 290 Query: 481 DAFDIGSF 488 D D Sbjct: 291 DDDDPEPL 298 >6GU6-A nrPDB Length = 302 Score = 243 bits (620), Expect = 2e-64, Method: Composition-based stats. Identities = 73/303 (24%), Positives = 122/303 (40%), Gaps = 43/303 (14%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 +M D++ IG G +G VY R TG++ AMK + + + E + +SL+ Sbjct: 5 SMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE----SEEEGVPSTAIREISLL 60 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ---HGVFSEADMRFYAAEIIL 303 P IV + +L I + ++ DL +L + ++ Y +I+ Sbjct: 61 KELRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQ 119 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEV 361 G+ H+R V++RDLKP N+L+D+ G ++++D GLA F + V T Y +PEV Sbjct: 120 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 179 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSFSPE 420 L Y + D +S+G + +L F D+ I R T E+ Sbjct: 180 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV-ES 238 Query: 421 LR--------------------------SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 L+ LL +L D +R+ + P+F Sbjct: 239 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFN 293 Query: 455 SLD 457 LD Sbjct: 294 DLD 296 >6HXF-B nrPDB Length = 302 Score = 242 bits (619), Expect = 3e-64, Method: Composition-based stats. Identities = 66/281 (23%), Positives = 130/281 (46%), Gaps = 18/281 (6%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + +G G FG+VY + +TG + A K ++ K E + + + +++T D Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETK------SEEELEDYIVEIEILATCD 74 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEHMH 309 P+IV + A++ KL +++ GG + + + +E ++ +++ L +H Sbjct: 75 HPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLH 134 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK--KKPHASVGTHGYMAPEVL----Q 363 ++ +++RDLK N+L+ G +R++D G++ K +K + +GT +MAPEV+ Sbjct: 135 SKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETM 194 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 K YD AD +SLG L ++ + P + + + P +S E R Sbjct: 195 KDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRD 254 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQ 464 L+ L ++ R A ++ E PF S+ + Sbjct: 255 FLKIALDKNPETR-----PSAAQLLEHPFVSSITSNKALRE 290 >1KOA-A nrPDB Length = 491 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 87/378 (23%), Positives = 144/378 (38%), Gaps = 46/378 (12%) Query: 174 FCQWKN-----VELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIK 228 F WK VE+ ++ + +H +G G FG V+ + TG +A K + Sbjct: 31 FDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV------ 84 Query: 229 MKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL-SQHG 287 M E+ R + +S P +V + AF +++ I + M+GG+L + +H Sbjct: 85 MTPHESDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHN 144 Query: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDE--HGHVRISDLGLACDFSKK 345 SE + Y ++ GL HMH V+ DLKP NI+ +++ D GL K Sbjct: 145 KMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPK 204 Query: 346 KP-HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEID 403 + + GT + APEV +G D +S+G + + LL G SPF + + Sbjct: 205 QSVKVTTGTAEFAAPEV-AEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVK 263 Query: 404 RMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF---------- 453 M S + + + LL D N R+ + E P+ Sbjct: 264 SCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIH-----QALEHPWLTPGNAPGRDS 318 Query: 454 --------RSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQEL 505 + D +P PL PP G ++ + E + S+ + Sbjct: 319 QIPSSRYTKIRDSIKTKYDAWPEPL-PPLGRISNYSSLRKHRPQEYSIRDAFWDRSEAQ- 376 Query: 506 YRNFPLTISERWQQEVAE 523 P I + + EV E Sbjct: 377 ----PRFIVKPYGTEVGE 390 >4WNO-A nrPDB Length = 287 Score = 242 bits (618), Expect = 4e-64, Method: Composition-based stats. Identities = 78/274 (28%), Positives = 123/274 (44%), Gaps = 22/274 (8%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTG-KMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +FS +IG G F V+ R A+KC++KK + Q TL E + ++ Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQ--TLLGKE---IKILKE 73 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 IV + + + +++ NGGDL +L SE +R + +I + + Sbjct: 74 LKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLL 133 Query: 309 HNRFVVYRDLKPANILLDEHG---------HVRISDLGLACDFSKKKPHAS-VGTHGYMA 358 H++ +++RDLKP NILL V+I+D G A A+ G+ YMA Sbjct: 134 HSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMA 193 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS 418 PEV+ YD AD +S+G ++++ L G +PF+ +D T+ +P S Sbjct: 194 PEVIM-SQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETS 252 Query: 419 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPF 452 LR LL LLQR+ R+ E PF Sbjct: 253 APLRQLLLALLQRNHKDRM-----DFDEFFHHPF 281 >1KOB-A nrPDB Length = 387 Score = 241 bits (616), Expect = 7e-64, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 134/307 (43%), Gaps = 24/307 (7%) Query: 158 RGDVFQKFIESDKFTRFCQWKNVELNIHLTM----NDFSVHRIIGRGGFGEVYGCRKADT 213 G + DKF K V + + + + + +G G FG V+ C + T Sbjct: 19 DGPKINDY---DKFYEDIWKKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKAT 75 Query: 214 GKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDL 273 G+++ K ++ K + +S+++ P ++ + AF ++ IL+ Sbjct: 76 GRVFVAKFINTPYPLDK------YTVKNEISIMNQLHHPKLINLHDAFEDKYEMVLILEF 129 Query: 274 MNGGDLHYHLSQHG-VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGH-- 330 ++GG+L ++ SEA++ Y + GL+HMH +V+ D+KP NI+ + Sbjct: 130 LSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASS 189 Query: 331 VRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHS 389 V+I D GLA + + + T + APE++ D +++G + + LL G S Sbjct: 190 VKIIDFGLATKLNPDEIVKVTTATAEFAAPEIV-DREPVGFYTDMWAIGVLGYVLLSGLS 248 Query: 390 PFRQHKTKDKHE-IDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVK 448 PF + + + R + S SPE + ++ LLQ++ +RL + Sbjct: 249 PFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFIKNLLQKEPRKRL-----TVHDAL 303 Query: 449 ESPFFRS 455 E P+ + Sbjct: 304 EHPWLKG 310 >3V5Q-A nrPDB Length = 297 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 59/283 (20%), Positives = 110/283 (38%), Gaps = 35/283 (12%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRK-----ADTGKMYAMKCLDKKRIKMKQGETLALNE 239 H+ D + R +G G FG+V+ + A+K L + ++ Sbjct: 11 HIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKD------F 64 Query: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV----------- 288 + L++ IV D L + + M GDL+ L HG Sbjct: 65 QREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPR 124 Query: 289 -----FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS 343 + M A++I G+ ++ ++ V+RDL N L+ + V+I D G++ D Sbjct: 125 QAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVY 184 Query: 344 KKKPHASVGT----HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 + G +M PE + + + +D +S G +L+++ G P+ Q + Sbjct: 185 STDYYRVGGHTMLPIRWMPPESIMY-RKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTE 243 Query: 399 KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLG 441 I+ +T +E P E+ ++ G QR+ +RL Sbjct: 244 V--IECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKE 284 >4KRC-A nrPDB Length = 317 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 67/304 (22%), Positives = 121/304 (39%), Gaps = 50/304 (16%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + F +G G + VY TG A+K +K+ E +SL+ Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALK-----EVKLDSEEGTPSTAIREISLMKE 59 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV------FSEADMRFYAAEII 302 IV + HT +KL+ + + M+ DL ++ V ++++ +++ Sbjct: 60 LKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPE 360 GL H +++RDLKP N+L+++ G +++ D GLA F + V T Y AP+ Sbjct: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEID----------------- 403 VL Y +S D +S GC+L +++ G F +++ ++ Sbjct: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 Query: 404 --RMTLTMAVELPDSFSPELR------------SLLEGLLQRDVNRRLGCLGRGAQEVKE 449 + + P L+ L GLLQ + + RL A++ Sbjct: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALH 293 Query: 450 SPFF 453 P+F Sbjct: 294 HPWF 297 >4MYG-A nrPDB Length = 372 Score = 240 bits (612), Expect = 2e-63, Method: Composition-based stats. Identities = 77/322 (23%), Positives = 130/322 (40%), Gaps = 61/322 (18%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 +G G +G V +G+ A+K L + Q E A L L+ ++ Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSR----PFQSEIFAKRAYRELLLLKHMQHENVIG 106 Query: 257 MSYAFHTPDKL------SFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 + F L ++ M DL + FSE +++ +++ GL+++H+ Sbjct: 107 LLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIMGME--FSEEKIQYLVYQMLKGLKYIHS 163 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDS 370 VV+RDLKP N+ ++E ++I D GLA + + V T Y APEV+ + Y+ Sbjct: 164 AGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTRWYRAPEVILSWMHYNQ 222 Query: 371 SADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAVELPDSF------------ 417 + D +S+GC++ ++L G + F+ D+ +I ++T E Sbjct: 223 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 282 Query: 418 ---------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVF 462 SP+ LLE +L+ DV++RL A + PFF Sbjct: 283 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHPFFE-------- 329 Query: 463 LQKYPPPLIPPRGEVNAADAFD 484 P P E A FD Sbjct: 330 ------PFRDPEEETEAQQPFD 345 >2X4F-A nrPDB Length = 373 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 65/267 (24%), Positives = 122/267 (45%), Gaps = 17/267 (6%) Query: 195 RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 254 I+G G FG+V+ C + TG A K + + +K K+ + +S+++ D + Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKE------EVKNEISVMNQLDHANL 148 Query: 255 VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEHMHNRFV 313 + + AF + + + +++ ++GG+L + +E D + +I G+ HMH ++ Sbjct: 149 IQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYI 208 Query: 314 VYRDLKPANILLDEH--GHVRISDLGLACDFSK-KKPHASVGTHGYMAPEVLQKGVAYDS 370 ++ DLKP NIL ++I D GLA + +K + GT ++APEV+ Sbjct: 209 LHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYD-FVSF 267 Query: 371 SADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSFSPELRSLLEGLL 429 D +S+G + + LL G SPF + + I + E S E + + LL Sbjct: 268 PTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLL 327 Query: 430 QRDVNRRLGCLGRGAQEVKESPFFRSL 456 ++ + R+ A E + P+ Sbjct: 328 IKEKSWRI-----SASEALKHPWLSDH 349 >6CKI-A nrPDB Length = 316 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 71/307 (23%), Positives = 123/307 (40%), Gaps = 43/307 (14%) Query: 189 NDFSVHR-IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + + + ++G G V C T + YA+K ++K+ ++ E M L Sbjct: 12 DVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRV---FREVEM--LYQ 66 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 ++ + F D+ + + M GG + H+ + F+E + ++ L+ Sbjct: 67 CQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDF 126 Query: 308 MHNRFVVYRDLKPANILLDEHGH---VRISDLGL---------ACDFSKKKPHASVGTHG 355 +HN+ + +RDLKP NIL + V+I D GL S + G+ Sbjct: 127 LHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAE 186 Query: 356 YMAPEVL----QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD------------K 399 YMAPEV+ ++ YD D +SLG +L+ LL G+ PF D + Sbjct: 187 YMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQ 246 Query: 400 HEIDRMTLTMAVELPD----SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 + + E PD S + L+ LL RD +RL A +V + P+ + Sbjct: 247 NMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRL-----SAAQVLQHPWVQG 301 Query: 456 LDWQMVF 462 + Sbjct: 302 CAPENTL 308 >3KA0-A nrPDB Length = 320 Score = 239 bits (609), Expect = 4e-63, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 121/292 (41%), Gaps = 32/292 (10%) Query: 178 KNVELNIHLTMNDFSV-HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA 236 +++ + ++D+ V +++G G G+V T + +A+K L ++ E Sbjct: 4 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHW 63 Query: 237 LNERIMLSLVSTGDCPFIVCMSYAFHT----PDKLSFILDLMNGGDLHYHLSQHG--VFS 290 CP IV + + L +++ ++GG+L + G F+ Sbjct: 64 ----------RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 113 Query: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDE---HGHVRISDLGLACDFSK-KK 346 E + I ++++H+ + +RD+KP N+L + ++++D G A + + Sbjct: 114 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS 173 Query: 347 PHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR-QHKTKDKHEIDRM 405 T Y+APEVL YD S D +SLG +++ LL G+ PF H + Sbjct: 174 LTEPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 232 Query: 406 TLTMAVELP----DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 E P S E++ L+ LL+ + +R+ E P+ Sbjct: 233 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT-----EFMNHPWI 279 >1NY3-A nrPDB Length = 400 Score = 239 bits (609), Expect = 4e-63, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 121/292 (41%), Gaps = 32/292 (10%) Query: 178 KNVELNIHLTMNDFSV-HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA 236 +++ + ++D+ V +++G G G+V T + +A+K L ++ E Sbjct: 50 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHW 109 Query: 237 LNERIMLSLVSTGDCPFIVCMSYAFHT----PDKLSFILDLMNGGDLHYHLSQHG--VFS 290 CP IV + + L +++ ++GG+L + G F+ Sbjct: 110 ----------RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 159 Query: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDE---HGHVRISDLGLACDFSK-KK 346 E + I ++++H+ + +RD+KP N+L + ++++D G A + + Sbjct: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS 219 Query: 347 PHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR-QHKTKDKHEIDRM 405 T Y+APEVL YD S D +SLG +++ LL G+ PF H + Sbjct: 220 LTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 Query: 406 TLTMAVELP----DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 E P S E++ L+ LL+ + +R+ E P+ Sbjct: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT-----EFMNHPWI 325 >2OZA-A nrPDB Length = 356 Score = 238 bits (608), Expect = 5e-63, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 121/292 (41%), Gaps = 32/292 (10%) Query: 178 KNVELNIHLTMNDFSV-HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA 236 +++ + ++D+ V +++G G G+V T + +A+K L ++ E Sbjct: 6 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHW 65 Query: 237 LNERIMLSLVSTGDCPFIVCMSYAFHT----PDKLSFILDLMNGGDLHYHLSQHG--VFS 290 CP IV + + L +++ ++GG+L + G F+ Sbjct: 66 ----------RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 115 Query: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDE---HGHVRISDLGLACDFSK-KK 346 E + I ++++H+ + +RD+KP N+L + ++++D G A + + Sbjct: 116 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS 175 Query: 347 PHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR-QHKTKDKHEIDRM 405 T Y+APEVL YD S D +SLG +++ LL G+ PF H + Sbjct: 176 LTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 234 Query: 406 TLTMAVELP----DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 E P S E++ L+ LL+ + +R+ E P+ Sbjct: 235 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT-----EFMNHPWI 281 >5DBX-A nrPDB Length = 328 Score = 237 bits (606), Expect = 8e-63, Method: Composition-based stats. Identities = 68/293 (23%), Positives = 126/293 (43%), Gaps = 32/293 (10%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + + + + +IG G V + A+K ++ ++ + E L + Sbjct: 6 WPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLK-----EI 60 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL--------SQHGVFSEADMR 295 +S P +V +F D+L ++ L++GG + + ++GV EA + Sbjct: 61 QAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIA 120 Query: 296 FYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-------H 348 E++ GL+++H ++RDLK NILL E G V+I+D G++ + Sbjct: 121 TILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRK 180 Query: 349 ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT 408 VGT +MAPEV+++ YD AD +S G +L G +P+ ++ + Sbjct: 181 DFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDP 240 Query: 409 MAV-------ELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 + E+ + R LL LQ+D ++R A E+ + FF+ Sbjct: 241 PTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKR-----PTAAELLKCKFFQ 288 >4APC-A nrPDB Length = 350 Score = 237 bits (605), Expect = 1e-62, Method: Composition-based stats. Identities = 65/254 (25%), Positives = 126/254 (49%), Gaps = 11/254 (4%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 +M + + IG G FG+ + + G+ Y +K ++ R+ K+ E R ++++ Sbjct: 22 SMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKERE----ESRREVAVL 77 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAEIILG 304 + P IV +F L ++D GGDL ++ +F E + + +I L Sbjct: 78 ANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLA 137 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVGTHGYMAPEVL 362 L+H+H+R +++RD+K NI L + G V++ D G+A + A +GT Y++PE + Sbjct: 138 LKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPE-I 196 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 + Y++ +D ++LGC+L++L F K+ + ++ + +S +LR Sbjct: 197 CENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNL--VLKIISGSFPPVSLHYSYDLR 254 Query: 423 SLLEGLLQRDVNRR 436 SL+ L +R+ R Sbjct: 255 SLVSQLFKRNPRDR 268 >4EWQ-A nrPDB Length = 383 Score = 237 bits (604), Expect = 2e-62, Method: Composition-based stats. Identities = 76/371 (20%), Positives = 140/371 (37%), Gaps = 67/371 (18%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + +G G +G V TG A+K L + Q A L L+ Sbjct: 45 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR----PFQSIIHAKRTYRELRLLKH 100 Query: 249 GDCPFIVCMSYAF------HTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 ++ + F + + + LM G DL+ + + ++ ++F +I+ Sbjct: 101 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTDDHVQFLIYQIL 158 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL 362 GL+++H+ +++RDLKP+N+ ++E ++I D GLA + + V T Y APE++ Sbjct: 159 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH-TDDEMTGYVATRWYRAPEIM 217 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSFS--- 418 + Y+ + D +S+GC++ +LL G + F D+ + I R+ T EL S Sbjct: 218 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 277 Query: 419 ------------------------PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 P LLE +L D ++R+ A + +F Sbjct: 278 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRI-----TAAQALAHAYF- 331 Query: 455 SLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQEL-YRNFPLTI 513 + + D +D+ L+D + L Y + Sbjct: 332 -----------------AQYHDPDDEPVAD--PYDQSFESRDLLIDEWKSLTYDEVISFV 372 Query: 514 SERWQQEVAET 524 QE E+ Sbjct: 373 PPPLDQEEMES 383 >4AT3-A nrPDB Length = 299 Score = 236 bits (603), Expect = 2e-62, Method: Composition-based stats. Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRK-----ADTGKMYAMKCLDKKRIKMKQGETLALNE 239 H+ ++ + R +G G FG+V+ + A+K L ++ Sbjct: 9 HIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD------F 62 Query: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV----------- 288 L++ IV D L + + M GDL+ L HG Sbjct: 63 HREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPP 122 Query: 289 --FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK 346 +++ M A +I G+ ++ ++ V+RDL N L+ E+ V+I D G++ D Sbjct: 123 TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTD 182 Query: 347 PHASVGT----HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHE 401 + G +M PE + + + +D +SLG +L+++ G P+ Q + Sbjct: 183 YYRVGGHTMLPIRWMPPESIMY-RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEV-- 239 Query: 402 IDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 I+ +T ++ P + E+ L+ G QR+ + R Sbjct: 240 IECITQGRVLQRPRTCPQEVYELMLGCWQREPHMR 274 >6E2O-A nrPDB Length = 295 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 68/272 (25%), Positives = 121/272 (44%), Gaps = 18/272 (6%) Query: 190 DFSVHR-----IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 D+ ++G+G +G VY R A+K + ++ + Q L+E I + Sbjct: 18 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQP----LHEEI--A 71 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFS--EADMRFYAAEI 301 L IV +F + ++ + GG L L + G E + FY +I Sbjct: 72 LHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQI 131 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDE-HGHVRISDLGLACDFSKKKP--HASVGTHGYMA 358 + GL+++H+ +V+RD+K N+L++ G ++ISD G + + P GT YMA Sbjct: 132 LEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMA 191 Query: 359 PEVLQKG-VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSF 417 PE++ KG Y +AD +SLGC + ++ G PF + + E+P+S Sbjct: 192 PEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESM 251 Query: 418 SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKE 449 S E ++ + + D ++R E + Sbjct: 252 SAEAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >3LM0-A nrPDB Length = 327 Score = 236 bits (602), Expect = 3e-62, Method: Composition-based stats. Identities = 70/297 (23%), Positives = 135/297 (45%), Gaps = 18/297 (6%) Query: 178 KNVELNIHLTMNDFSVH--RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL 235 +N+ N+F + + +GRG F V C TG+ YA K L K+R + + Sbjct: 16 ENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRR-RGQDCRAE 74 Query: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL--SQHGVFSEAD 293 L+E +L L + CP ++ + + ++ IL+ GG++ + SE D Sbjct: 75 ILHEIAVLELAKS--CPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSEND 132 Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDE---HGHVRISDLGLACDFSKK-KPHA 349 + +I+ G+ ++H +V+ DLKP NILL G ++I D G++ + Sbjct: 133 VIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELRE 192 Query: 350 SVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLT 408 +GT Y+APE+L ++ D +++G + + LL SPF ++ + I ++ + Sbjct: 193 IMGTPEYLAPEILNYD-PITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVD 251 Query: 409 MAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQK 465 + E S S ++ LL ++ +R A+ + + D++ +F + Sbjct: 252 YSEETFSSVSQLATDFIQSLLVKNPEKR-----PTAEICLSHSWLQQWDFENLFHPE 303 >4P5Q-A nrPDB Length = 361 Score = 234 bits (598), Expect = 8e-62, Method: Composition-based stats. Identities = 57/266 (21%), Positives = 110/266 (41%), Gaps = 18/266 (6%) Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKM---YAMKCLDKKRIKMKQGETLAL 237 E L + S+ +++G G FGEV R K A+K L + ++ + L Sbjct: 25 EFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLG- 83 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRF 296 S++ D P I+ + + + + M G L L +H F+ + Sbjct: 84 ----EASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVG 139 Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVG-- 352 I G++++ + V+RDL NIL++ + ++SD GL+ + + G Sbjct: 140 MLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGK 199 Query: 353 -THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMA 410 + +PE + + S++D +S G +L++++ G P+ + +D I + Sbjct: 200 IPIRWTSPEAIAY-RKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDV--IKAVDEGYR 256 Query: 411 VELPDSFSPELRSLLEGLLQRDVNRR 436 + P L L+ Q+D N R Sbjct: 257 LPPPMDCPAALYQLMLDCWQKDRNNR 282 >1CM8-A nrPDB Length = 367 Score = 234 bits (598), Expect = 8e-62, Method: Composition-based stats. Identities = 73/300 (24%), Positives = 124/300 (41%), Gaps = 46/300 (15%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + +G G +G V TG A+K L + Q E A L L+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL----YRPFQSELFAKRAYRELRLLKHMR 82 Query: 251 CPFIVCMSYAFHTPDKL------SFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 ++ + F + L ++ M G DL L +H E ++F +++ G Sbjct: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGK-LMKHEKLGEDRIQFLVYQMLKG 140 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 364 L ++H +++RDLKP N+ ++E ++I D GLA + + V T Y APEV+ Sbjct: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVTRWYRAPEVILN 199 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSF------ 417 + Y + D +S+GC++ +++ G + F+ D+ EI ++T T E Sbjct: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 Query: 418 ---------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 SP +LLE +L D +R+ A E P+F SL Sbjct: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAHPYFESL 314 >4AN9-A nrPDB Length = 301 Score = 234 bits (597), Expect = 1e-61, Method: Composition-based stats. Identities = 65/284 (22%), Positives = 126/284 (44%), Gaps = 15/284 (5%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 L +DF +G G G V+ +G + A K + ++ + L Sbjct: 5 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI-----HLEIKPAIRNQIIRELQ 59 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 ++ + P+IV AF++ ++S ++ M+GG L L + G E + + +I G Sbjct: 60 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 119 Query: 305 LEHM-HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 363 L ++ +++RD+KP+NIL++ G +++ D G++ + + VGT YM+PE LQ Sbjct: 120 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQ 179 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS-FSPELR 422 G Y +D +S+G L ++ G P + +D + +LP + FS E + Sbjct: 180 -GTHYSVQSDIWSMGLSLVEMAVGRYP--RPPMAIFELLDYIVNEPPPKLPSAVFSLEFQ 236 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKY 466 + L ++ R +++ F + D + V + Sbjct: 237 DFVNKCLIKNPAER-----ADLKQLMVHAFIKRSDAEEVDFAGW 275 >1V0B-A nrPDB Length = 288 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 129/299 (43%), Gaps = 40/299 (13%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 M + IG G +G VY + + G+ +A+K + + K+ E + +S++ Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLE----KEDEGIPSTTIREISILK 55 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL-SQHGVFSEADMRFYAAEIILGLE 306 IV + HT +L + + ++ DL L G + + +++ G+ Sbjct: 56 ELKHSNIVKLYDVIHTKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIA 114 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQK 364 + H+R V++RDLKP N+L++ G ++I+D GLA F +K V T Y AP+VL Sbjct: 115 YCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMG 174 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSFSPELR- 422 Y ++ D +S+GC+ +++ G F D+ I R+ T + + + + Sbjct: 175 SKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKY 234 Query: 423 ------------------------SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 LL +L+ D N+R+ A++ E +F+ + Sbjct: 235 DPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRI-----TAKQALEHAYFKENN 288 >4BBM-A nrPDB Length = 331 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 61/311 (19%), Positives = 117/311 (37%), Gaps = 39/311 (12%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 +M + ++G G +G V CR DTG++ A+K ++ + + + L+ Sbjct: 23 SMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKF----LESDDDKMVKKIAMREIKLL 78 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 +V + + + + ++ L ++ Y +II G+ Sbjct: 79 KQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIG 138 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQK 364 H+ +++RD+KP NIL+ + G V++ D G A + V T Y APE+L Sbjct: 139 FCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVG 198 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD----------------KHEIDRMTLT 408 V Y + D +++GC++ ++ G F D + ++ + Sbjct: 199 DVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVF 258 Query: 409 MAVELP------------DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 V LP S + L + L D ++R C E+ FF+ Sbjct: 259 AGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFC-----AELLHHDFFQMD 313 Query: 457 DWQMVFLQKYP 467 + F Q+ Sbjct: 314 GFAERFSQELQ 324 >3DKO-A nrPDB Length = 318 Score = 233 bits (595), Expect = 2e-61, Method: Composition-based stats. Identities = 65/302 (21%), Positives = 121/302 (40%), Gaps = 21/302 (6%) Query: 146 FQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV-ELNIHLTMNDFSVHRIIGRGGFGE 204 Q EE+ + + + +I D T + V + L + + R+IG G FGE Sbjct: 1 MQEGDEELYFHFKFPGTKTYI--DPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGE 58 Query: 205 VYGCRKADTGKM---YAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAF 261 V R GK A+K L + ++ + L S++ D P +V + Sbjct: 59 VCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLC-----EASIMGQFDHPNVVHLEGVV 113 Query: 262 HTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKP 320 + +++ M G L L +H G F+ + I G+ ++ + V+RDL Sbjct: 114 TRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAA 173 Query: 321 ANILLDEHGHVRISDLGLACDFSKKKPHASVGT-----HGYMAPEVLQKGVAYDSSADWF 375 NIL++ + ++SD GL+ T + APE +Q + S++D + Sbjct: 174 RNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQY-RKFTSASDVW 232 Query: 376 SLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVN 434 S G ++++++ G P+ +D I + + P L L+ Q++ Sbjct: 233 SYGIVMWEVMSYGERPYWDMSNQDV--IKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERA 290 Query: 435 RR 436 R Sbjct: 291 ER 292 >2BRG-A nrPDB Length = 297 Score = 232 bits (593), Expect = 3e-61, Method: Composition-based stats. Identities = 59/270 (21%), Positives = 116/270 (42%), Gaps = 14/270 (5%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + D+ + + +G G +GEV T + A+K +D MK+ N + + + Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVD-----MKRAVDCPENIKKEICINK 60 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 + +V + L+ +GG+L + E D + + +++ G+ + Sbjct: 61 MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY 120 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK----PHASVGTHGYMAPEVLQ 363 +H + +RD+KP N+LLDE +++ISD GLA F + GT Y+APE+L+ Sbjct: 121 LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK 180 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 + + D +S G +L +L G P+ Q + D + + Sbjct: 181 RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA 240 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 LL +L + + R+ ++K+ ++ Sbjct: 241 LLHKILVENPSARITI-----PDIKKDRWY 265 >1JPA-A nrPDB Length = 312 Score = 232 bits (591), Expect = 5e-61, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 119/281 (42%), Gaps = 21/281 (7%) Query: 169 DKFTRFCQWKNV-ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKM---YAMKCLDK 224 D FT + V E + ++ + ++IG G FGEV GK A+K L Sbjct: 12 DPFTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKS 71 Query: 225 KRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS 284 + ++ + L+ S++ D P ++ + + I + M G L L Sbjct: 72 GYTEKQRRDFLS-----EASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR 126 Query: 285 QH-GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS 343 Q+ G F+ + I G++++ + V+RDL NIL++ + ++SD GL+ Sbjct: 127 QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLE 186 Query: 344 KK----KPHASVG---THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHK 395 +++G + APE +Q + S++D +S G ++++++ G P+ Sbjct: 187 DDTSDPTYTSALGGKIPIRWTAPEAIQY-RKFTSASDVWSYGIVMWEVMSYGERPYWDMT 245 Query: 396 TKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 +D I+ + + P L L+ Q+D N R Sbjct: 246 NQDV--INAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHR 284 >4AU8-A nrPDB Length = 296 Score = 231 bits (590), Expect = 6e-61, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 126/295 (42%), Gaps = 38/295 (12%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + IG G +G V+ + +T ++ A+K + E + + + L+ Sbjct: 8 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD----DDDEGVPSSALREICLLKELK 63 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 IV + H+ KL+ + + + Y S +G ++ + +++ GL H+ Sbjct: 64 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 123 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQKGVAY 368 R V++RDLKP N+L++ +G ++++D GLA F + A V T Y P+VL Y Sbjct: 124 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 183 Query: 369 DSSADWFSLGCMLFKLL-RGHSPFRQHKTKDKHE-IDRMTLTMAVE-------LPD---- 415 +S D +S GC+ +L G F + D+ + I R+ T E LPD Sbjct: 184 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 243 Query: 416 --------------SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 + R LL+ LL+ + +R+ A+E + P+F Sbjct: 244 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFSDF 293 >6DTL-A nrPDB Length = 364 Score = 231 bits (590), Expect = 6e-61, Method: Composition-based stats. Identities = 66/293 (22%), Positives = 119/293 (40%), Gaps = 43/293 (14%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG+G +G V ++T + A+K + + A + L+ D IV Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKI----ANAFDNKIDAKRTLREIKLLRHMDHENIVA 93 Query: 257 MSYAFHTP-----DKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNR 311 + P + + +LM+ DLH + + SE +++ +I+ GL+++H+ Sbjct: 94 IRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 152 Query: 312 FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGVAYDS 370 V++RDLKP+N+LL+ + ++I D GLA S+ V T Y APE+L Y + Sbjct: 153 NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 212 Query: 371 SADWFSLGCMLFKLLRGHSPFRQHKTKDKHEID-------------------RMTLTMAV 411 + D +S+GC+ +L+ F + + + + Sbjct: 213 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLP 272 Query: 412 ELP--------DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 P + P L+E +L D RR+ L + P+ SL Sbjct: 273 PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVL-----DALAHPYLNSL 320 >3PPZ-A nrPDB Length = 309 Score = 231 bits (589), Expect = 7e-61, Method: Composition-based stats. Identities = 65/273 (23%), Positives = 119/273 (43%), Gaps = 18/273 (6%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 D ++ IG G FG V+ G A+K L ++ ++ IM L Sbjct: 38 DLNIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVNEFLREVAIMKRL---- 91 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV---FSEADMRFYAAEIILGLE 306 P IV A P LS + + ++ G L+ L + G E A ++ G+ Sbjct: 92 RHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMN 151 Query: 307 HMHNRF--VVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHASVGTHGYMAPEVL 362 ++HNR +V+RDLK N+L+D+ V++ D GL+ + ++ GT +MAPEVL Sbjct: 152 YLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVL 211 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 + + + +D +S G +L++L P+ +E+P + +P++ Sbjct: 212 RDEPS-NEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAV-GFKCKRLEIPRNLNPQVA 269 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 +++EG + +R ++ P +S Sbjct: 270 AIIEGCWTNEPWKRPSF--ATIMDLLR-PLIKS 299 >4X7Q-B nrPDB Length = 312 Score = 231 bits (588), Expect = 1e-60, Method: Composition-based stats. Identities = 60/272 (22%), Positives = 120/272 (44%), Gaps = 20/272 (7%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI----KMKQGETLALNERIMLSL 245 ++ + ++G+GGFG V+ + A+K + + R+ + T L ++ + Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDL-MNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 + G P ++ + F T + +L+ + DL ++++ G E R + +++ Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 151 Query: 305 LEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 363 ++H H+R VV+RD+K NIL+D G ++ D G + GT Y PE + Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWIS 211 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 + + A +SLG +L+ ++ G PF E D+ L + P SP+ + Sbjct: 212 RHQYHALPATVWSLGILLYDMVCGDIPF---------ERDQEILEAELHFPAHVSPDCCA 262 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 L+ L + R +E+ P+ ++ Sbjct: 263 LIRRCLAPKPSSR-----PSLEEILLDPWMQT 289 >3OHT-A nrPDB Length = 389 Score = 230 bits (586), Expect = 2e-60, Method: Composition-based stats. Identities = 73/346 (21%), Positives = 139/346 (40%), Gaps = 57/346 (16%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + +G G +G V +G A+K L + Q A L L+ Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSR----PFQSIIHAKRTYRELRLLKH 106 Query: 249 GDCPFIVCMSYAF------HTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 ++ + F + + + LM G DL+ + + ++ ++F +I+ Sbjct: 107 MKHENVIGLLDVFTPATSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTDDHVQFLIYQIL 164 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL 362 GL+++H+ +++RDLKP+N+ ++E ++I D GLA + + V T Y APE++ Sbjct: 165 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH-TDDEMTGYVATRWYRAPEIM 223 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMA----------- 410 + Y+ + D +S+GC++ +LL G + F ++ +I R+T T Sbjct: 224 LNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHE 283 Query: 411 --------VELPDS--------FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 ++P +P LLE +L D ++R+ A E P+F Sbjct: 284 ARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRI-----TASEALAHPYFS 338 Query: 455 SLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLD 500 +Y P P E F+ + E+ K + + Sbjct: 339 ----------QYHDPDDEPESEPYDQS-FESRQLEIEEWKRLTYEE 373 >5KMM-A nrPDB Length = 329 Score = 230 bits (586), Expect = 2e-60, Method: Composition-based stats. Identities = 58/287 (20%), Positives = 110/287 (38%), Gaps = 34/287 (11%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKAD-----TGKMYAMKCLDKKRIKMKQGETLALN 238 H+ D + +G G FG+V+ + + A+K L + +Q Sbjct: 30 HHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD------ 83 Query: 239 ERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV---------- 288 + L++ IV L + + M GDL+ L HG Sbjct: 84 FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED 143 Query: 289 -----FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS 343 + A+++ G+ ++ V+RDL N L+ + V+I D G++ D Sbjct: 144 VAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIY 203 Query: 344 KKKPHASVG----THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 + G +M PE + + + +D +S G +L+++ G P+ Q + Sbjct: 204 STDYYRVGGRTMLPIRWMPPESILY-RKFTTESDVWSFGVVLWEIFTYGKQPWYQLS--N 260 Query: 399 KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQ 445 ID +T +E P + PE+ +++ G QR+ +R A+ Sbjct: 261 TEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR 307 >4GS6-A nrPDB Length = 315 Score = 230 bits (586), Expect = 2e-60, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 124/308 (40%), Gaps = 28/308 (9%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + V ++GRG FG V + K A+K + + E+ + L +S Sbjct: 10 EIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQI--------ESESERKAFIVELRQLSRV 59 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVF---SEADMRFYAAEIILGLE 306 + P IV + A P + +++ GG L+ L + A + + G+ Sbjct: 60 NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 117 Query: 307 HMHNRF---VVYRDLKPANILLDEHGHV-RISDLGLACDFSKKKPHASVGTHGYMAPEVL 362 ++H+ +++RDLKP N+LL G V +I D G ACD + + G+ +MAPEV Sbjct: 118 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI-QTHMTNNKGSAAWMAPEVF 176 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 +G Y D FS G +L++++ PF + + + L + + Sbjct: 177 -EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIE 235 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKES--PFFRSLDWQMVFLQKYPPPLIPPRGEVNAA 480 SL+ +D ++R ++ +F D + + ++ +PP + Sbjct: 236 SLMTRCWSKDPSQRPSMEE--IVKIMTHLMRYFPGADEPLQYPCQHS---LPPGEDGRVE 290 Query: 481 DAFDIGSF 488 D F Sbjct: 291 PYVDFAEF 298 >5MJB-A nrPDB Length = 305 Score = 230 bits (586), Expect = 2e-60, Method: Composition-based stats. Identities = 58/257 (22%), Positives = 107/257 (41%), Gaps = 20/257 (7%) Query: 192 SVHRIIGRGGFGEVYGCRKADTGK---MYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + +IG G FGEVY R GK A+K L + ++ + L+ S++ Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLS-----EASIMGQ 83 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLEH 307 D I+ + + I + M L L Q+ G F+ + I G+++ Sbjct: 84 FDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKY 143 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK----KPHASVG---THGYMAPE 360 + V+RDL NIL++ + ++SD GL+ +S+G + APE Sbjct: 144 LSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPE 203 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSP 419 + + S++D +S G ++++++ G P+ +D I+ + + P Sbjct: 204 AIAY-RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDV--INAIEQDYRLPPPMDCPA 260 Query: 420 ELRSLLEGLLQRDVNRR 436 L L+ Q+D N R Sbjct: 261 ALHQLMLDCWQKDRNSR 277 >3VN9-A nrPDB Length = 340 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 67/281 (23%), Positives = 123/281 (43%), Gaps = 21/281 (7%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 N + +D +GRG +G V R +G++ A+K + + + ++ + L ++ I Sbjct: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDIS 103 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYH----LSQHGVFSEADMRFYA 298 + T DCPF V A + ++LM+ L + + E + A Sbjct: 104 ---MRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIA 159 Query: 299 AEIILGLEHMHNR-FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA-SVGTHGY 356 I+ LEH+H++ V++RD+KP+N+L++ G V++ D G++ G Y Sbjct: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY 219 Query: 357 MAPEVLQ---KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVEL 413 MAPE + Y +D +SLG + +L P+ T ++ ++ + +L Sbjct: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP-FQQLKQVVEEPSPQL 278 Query: 414 P-DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 P D FS E L+++ R E+ + PFF Sbjct: 279 PADKFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 314 >4XEY-B nrPDB Length = 408 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 48/260 (18%), Positives = 106/260 (40%), Gaps = 16/260 (6%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 + D ++ +G G +GEVY A+K L + +++++ Sbjct: 119 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF-------LKE 171 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADMRFYAAE 300 +++ P +V + I + M G+L +L + + + + A + Sbjct: 172 AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQ 231 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG---THGYM 357 I +E++ + ++RDL N L+ E+ V+++D GL+ + A G + Sbjct: 232 ISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 291 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 APE L + +D ++ G +L+++ G SP+ +E+ + +E P+ Sbjct: 292 APESLAYN-KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYEL--LEKDYRMERPEG 348 Query: 417 FSPELRSLLEGLLQRDVNRR 436 ++ L+ Q + + R Sbjct: 349 CPEKVYELMRACWQWNPSDR 368 >2F9G-A nrPDB Length = 353 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 70/351 (19%), Positives = 134/351 (38%), Gaps = 68/351 (19%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +DF + ++G G +G V TG++ A+K ++ AL + ++ Sbjct: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-----PFDKPLFALRTLREIKILKH 65 Query: 249 GDCPFIVCMS-----YAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 I+ + +F +++ I +LM DLH +S + S+ ++++ + + Sbjct: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQ-MLSDDHIQYFIYQTLR 123 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK------------KKPHASV 351 ++ +H V++RDLKP+N+L++ + +++ D GLA + V Sbjct: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 Query: 352 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT--- 408 T Y APEV+ Y + D +S GC+L +L F + + + + Sbjct: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 Query: 409 --------------------------MAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGR 442 ++ +P+ LL+ +L D +R+ Sbjct: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI----- 298 Query: 443 GAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDT 493 A+E E P+ LQ Y P P GE F+ + E T Sbjct: 299 TAKEALEHPY----------LQTYHDPNDEPEGEPIPPSFFEFDHYKEALT 339 >2Y6O-A nrPDB Length = 291 Score = 229 bits (583), Expect = 4e-60, Method: Composition-based stats. Identities = 55/266 (20%), Positives = 110/266 (41%), Gaps = 18/266 (6%) Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKM---YAMKCLDKKRIKMKQGETLAL 237 E + + + ++IG G FGEV R GK A+K L ++ + L+ Sbjct: 6 EFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLS- 64 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRF 296 S++ D P I+ + + I + M G L L ++ G F+ + Sbjct: 65 ----EASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVG 120 Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVG-- 352 I G++++ + V+RDL NIL++ + ++SD G++ + + G Sbjct: 121 MLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGK 180 Query: 353 -THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMA 410 + APE + + S++D +S G ++++++ G P+ +D I + Sbjct: 181 IPIRWTAPEAIAY-RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDV--IKAIEEGYR 237 Query: 411 VELPDSFSPELRSLLEGLLQRDVNRR 436 + P L L+ Q++ + R Sbjct: 238 LPPPMDCPIALHQLMLDCWQKERSDR 263 >4IC8-A nrPDB Length = 442 Score = 228 bits (581), Expect = 6e-60, Method: Composition-based stats. Identities = 72/343 (20%), Positives = 127/343 (37%), Gaps = 65/343 (18%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ + IG G +G V R+ TG+ A+K + T A L ++ Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIP----NAFDVVTNAKRTLRELKILKH 110 Query: 249 GDCPFIVCMSYA------FHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 I+ + + + +LDLM DLH + + +R++ +++ Sbjct: 111 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLL 169 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK------PHASVGTHGY 356 GL++MH+ V++RDLKP+N+L++E+ ++I D G+A V T Y Sbjct: 170 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 229 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE---- 412 APE++ Y + D +S+GC+ ++L F + ++ M L Sbjct: 230 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 289 Query: 413 ---------LPDSFSP---------------ELRSLLEGLLQRDVNRRLGCLGRGAQEVK 448 S P + SLL +L+ + + R+ A Sbjct: 290 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARI-----SAAAAL 344 Query: 449 ESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEE 491 PF P E + A FD FD E Sbjct: 345 RHPFL--------------AKYHDPDDEPDCAPPFDFA-FDRE 372 >4BGQ-A nrPDB Length = 304 Score = 228 bits (581), Expect = 7e-60, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 117/305 (38%), Gaps = 42/305 (13%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 NI MN F + ++G G +G V CR +T ++ A+K ++ E + Sbjct: 6 NIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFK----DSEENEEVKETTLRE 61 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 L ++ T IV + AF KL + + + L ++ Y ++I Sbjct: 62 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI 121 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHASVGTHGYMAP 359 + H +V+RD+KP N+L+ + +++ D G A + S+ V T Y +P Sbjct: 122 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSP 181 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT----------- 408 E+L G Y S D +S+GC+L +L G F D+ + L Sbjct: 182 ELLL-GAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFY 240 Query: 409 -----MAVELPDSFSPE-------------LRSLLEGLLQRDVNRRLGCLGRGAQEVKES 450 + P P+ L L++ LL+ D R ++ Sbjct: 241 SNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYL-----TEQCLNH 295 Query: 451 PFFRS 455 P F++ Sbjct: 296 PTFQT 300 >4UY9-A nrPDB Length = 323 Score = 227 bits (580), Expect = 9e-60, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 123/284 (43%), Gaps = 20/284 (7%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + + + ++ IIG GGFG+VY G A+K + N R Sbjct: 4 LEIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDP--DEDISQTIENVRQEA 59 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 L + P I+ + L +++ GG L+ LS + +A +I Sbjct: 60 KLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLS-GKRIPPDILVNWAVQIAR 118 Query: 304 GLEHMHNRFV---VYRDLKPANILLD--------EHGHVRISDLGLACDFSKKKPHASVG 352 G+ ++H+ + ++RDLK +NIL+ + ++I+D GLA ++ + ++ G Sbjct: 119 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAG 178 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE 412 T+ +MAPEV++ + + +D +S G +L++LL G PFR M +A+ Sbjct: 179 TYAWMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNK-LALP 236 Query: 413 LPDSFSPELRSLLEGLLQRDVNRR--LGCLGRGAQEVKESPFFR 454 +P + L+E D + R + ++ES FF Sbjct: 237 IPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFE 280 >3FME-A nrPDB Length = 290 Score = 227 bits (580), Expect = 1e-59, Method: Composition-based stats. Identities = 66/281 (23%), Positives = 124/281 (44%), Gaps = 21/281 (7%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 ++ + +D +GRG +G V R +G++ A+K + + + ++ + L ++ I Sbjct: 1 SMEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDIS 59 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYH----LSQHGVFSEADMRFYA 298 + T DCPF V A + ++LM+ L + + E + A Sbjct: 60 ---MRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIA 115 Query: 299 AEIILGLEHMHNR-FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA-SVGTHGY 356 I+ LEH+H++ V++RD+KP+N+L++ G V++ D G++ G Y Sbjct: 116 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPY 175 Query: 357 MAPEVLQ---KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVEL 413 MAPE + Y +D +SLG + +L P+ T ++ ++ + +L Sbjct: 176 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP-FQQLKQVVEEPSPQL 234 Query: 414 P-DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 P D FS E L+++ R E+ + PFF Sbjct: 235 PADKFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 270 >4ZSG-A nrPDB Length = 347 Score = 227 bits (580), Expect = 1e-59, Method: Composition-based stats. Identities = 72/343 (20%), Positives = 127/343 (37%), Gaps = 65/343 (18%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ + IG G +G V R+ TG+ A+K + T A L ++ Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIP----NAFDVVTNAKRTLRELKILKH 62 Query: 249 GDCPFIVCMSYA------FHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 I+ + + + +LDLM DLH + + +R++ +++ Sbjct: 63 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLL 121 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK------PHASVGTHGY 356 GL++MH+ V++RDLKP+N+L++E+ ++I D G+A V T Y Sbjct: 122 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 181 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE---- 412 APE++ Y + D +S+GC+ ++L F + ++ M L Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 241 Query: 413 ---------LPDSFSP---------------ELRSLLEGLLQRDVNRRLGCLGRGAQEVK 448 S P + SLL +L+ + + R+ A Sbjct: 242 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARI-----SAAAAL 296 Query: 449 ESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEE 491 PF P E + A FD FD E Sbjct: 297 RHPFL--------------AKYHDPDDEPDCAPPFDFA-FDRE 324 >4EBW-A nrPDB Length = 304 Score = 227 bits (579), Expect = 1e-59, Method: Composition-based stats. Identities = 61/263 (23%), Positives = 109/263 (41%), Gaps = 17/263 (6%) Query: 182 LNIHLTMNDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALN 238 + + + R IG G FG+V+ + A+K K L Sbjct: 31 RDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKT--CKNCTSDSVREKFLQ 88 Query: 239 ERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFY 297 E + + D P IV + T + + I++L G+L L A + Y Sbjct: 89 EAL---TMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKYSLDLASLILY 144 Query: 298 AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH-ASVG--TH 354 A ++ L ++ ++ V+RD+ N+L+ + V++ D GL+ + AS G Sbjct: 145 AYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPI 204 Query: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFK-LLRGHSPFRQHKTKDKHEIDRMTLTMAVEL 413 +MAPE + + S++D + G +++ L+ G PF+ K D I R+ + + Sbjct: 205 KWMAPESINFRR-FTSASDVWMFGVCMWEILMHGVKPFQGVKNNDV--IGRIENGERLPM 261 Query: 414 PDSFSPELRSLLEGLLQRDVNRR 436 P + P L SL+ D +RR Sbjct: 262 PPNCPPTLYSLMTKCWAYDPSRR 284 >2VWV-A nrPDB Length = 302 Score = 227 bits (579), Expect = 1e-59, Method: Composition-based stats. Identities = 58/268 (21%), Positives = 111/268 (41%), Gaps = 20/268 (7%) Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKM---YAMKCLDKKRIKMKQGETLAL 237 E + ++ + +IG G FGEV R GK A+K L + ++ E L+ Sbjct: 8 EFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLS- 66 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRF 296 S++ + P I+ + + + + M G L L + G F+ + Sbjct: 67 ----EASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVG 122 Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK----PHASVG 352 I G+ ++ V+RDL NIL++ + ++SD GL+ + +S+G Sbjct: 123 MLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLG 182 Query: 353 ---THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLT 408 + APE + + S++D +S G ++++++ G P+ +D I+ + Sbjct: 183 GKIPIRWTAPEAIAF-RKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDV--INAIEQD 239 Query: 409 MAVELPDSFSPELRSLLEGLLQRDVNRR 436 + P L L+ Q+D N R Sbjct: 240 YRLPPPPDCPTSLHQLMLDCWQKDRNAR 267 >3DTC-A nrPDB Length = 271 Score = 227 bits (578), Expect = 2e-59, Method: Composition-based stats. Identities = 62/264 (23%), Positives = 115/264 (43%), Gaps = 18/264 (6%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + + + ++ IIG GGFG+VY G A+K + N R Sbjct: 2 LEIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDP--DEDISQTIENVRQEA 57 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 L + P I+ + L +++ GG L+ LS + +A +I Sbjct: 58 KLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLS-GKRIPPDILVNWAVQIAR 116 Query: 304 GLEHMHNRF---VVYRDLKPANILL--------DEHGHVRISDLGLACDFSKKKPHASVG 352 G+ ++H+ +++RDLK +NIL+ + ++I+D GLA ++ + ++ G Sbjct: 117 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAG 176 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE 412 + +MAPEV++ + + +D +S G +L++LL G PFR M +A+ Sbjct: 177 AYAWMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNK-LALP 234 Query: 413 LPDSFSPELRSLLEGLLQRDVNRR 436 +P + L+E D + R Sbjct: 235 IPSTCPEPFAKLMEDCWNPDPHSR 258 >2XYN-A nrPDB Length = 292 Score = 227 bits (578), Expect = 2e-59, Method: Composition-based stats. Identities = 46/260 (17%), Positives = 105/260 (40%), Gaps = 16/260 (6%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 + D ++ +G G +GEVY A+K L + +++++ Sbjct: 26 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEF-------LKE 78 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAE 300 +++ P +V + + + M G+L +L + + + + A + Sbjct: 79 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 138 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG---THGYM 357 I +E++ + ++RDL N L+ E+ V+++D GL+ + A G + Sbjct: 139 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 198 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 APE L + +D ++ G +L+++ G SP+ +++ + +E P+ Sbjct: 199 APESLAYN-TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDL--LEKGYRMEQPEG 255 Query: 417 FSPELRSLLEGLLQRDVNRR 436 P++ L+ + R Sbjct: 256 CPPKVYELMRACWKWSPADR 275 >5G6V-A nrPDB Length = 324 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 126/299 (42%), Gaps = 41/299 (13%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 M + +G G + VY + T + A+K I+++ E +SL+ Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALK-----EIRLEHEEGAPCTAIREVSLLK 55 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIILGLE 306 IV + HT L+ + + ++ DL +L G + + +++ + +++ GL Sbjct: 56 DLKHANIVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLA 114 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD--FSKKKPHASVGTHGYMAPEVLQK 364 + H + V++RDLKP N+L++E G ++++D GLA K V T Y P++L Sbjct: 115 YCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLG 174 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSF--SPEL 421 Y + D + +GC+ +++ G F +++ H I R+ T E + E Sbjct: 175 STDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEF 234 Query: 422 R------------------------SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 + LL LLQ + R+ A++ + PFF SL Sbjct: 235 KTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRI-----SAEDAMKHPFFLSL 288 >2FO0-A nrPDB Length = 495 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 47/260 (18%), Positives = 106/260 (40%), Gaps = 16/260 (6%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 + D ++ +G G +GEVY A+K L + +++++ Sbjct: 211 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF-------LKE 263 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADMRFYAAE 300 +++ P +V + I + M G+L +L + + + + A + Sbjct: 264 AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQ 323 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG---THGYM 357 I +E++ + ++R+L N L+ E+ V+++D GL+ + A G + Sbjct: 324 ISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 383 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 APE L + +D ++ G +L+++ G SP+ +E+ + +E P+ Sbjct: 384 APESLAYN-KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYEL--LEKDYRMERPEG 440 Query: 417 FSPELRSLLEGLLQRDVNRR 436 ++ L+ Q + + R Sbjct: 441 CPEKVYELMRACWQWNPSDR 460 >2R2P-A nrPDB Length = 295 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 57/266 (21%), Positives = 112/266 (42%), Gaps = 18/266 (6%) Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKM---YAMKCLDKKRIKMKQGETLAL 237 E + + ++ R+IG G FGEV R GK A+K L + ++ + L Sbjct: 14 EFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLG- 72 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRF 296 S++ D P I+ + + + + M G L L ++ G F+ + Sbjct: 73 ----EASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVG 128 Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVG-- 352 I G++++ + V+RDL NIL++ + ++SD GL+ + + G Sbjct: 129 MLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGK 188 Query: 353 -THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMA 410 + APE + + S++D +S G ++++++ G P+ + +D I + Sbjct: 189 IPIRWTAPEAIAF-RKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDV--IKAVEEGYR 245 Query: 411 VELPDSFSPELRSLLEGLLQRDVNRR 436 + P L L+ Q++ N R Sbjct: 246 LPSPMDCPAALYQLMLDCWQKERNSR 271 >6NPU-A nrPDB Length = 298 Score = 226 bits (575), Expect = 4e-59, Method: Composition-based stats. Identities = 48/260 (18%), Positives = 106/260 (40%), Gaps = 16/260 (6%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 + D ++ +G G +GEVY A+K L + +++++ Sbjct: 20 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF-------LKE 72 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADMRFYAAE 300 +++ P +V + I + M G+L +L + + + + A + Sbjct: 73 AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQ 132 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG---THGYM 357 I +E++ + ++RDL N L+ E+ V+++D GL+ + A G + Sbjct: 133 ISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 192 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 APE L + +D ++ G +L+++ G SP+ +E+ + +E P+ Sbjct: 193 APESLAYN-KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYEL--LEKDYRMERPEG 249 Query: 417 FSPELRSLLEGLLQRDVNRR 436 ++ L+ Q + + R Sbjct: 250 CPEKVYELMRACWQWNPSDR 269 >4U41-A nrPDB Length = 332 Score = 225 bits (574), Expect = 4e-59, Method: Composition-based stats. Identities = 67/283 (23%), Positives = 120/283 (42%), Gaps = 34/283 (12%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F + ++G G +G+VY R TG++ A+K +D + E ML S Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE----EEIKLEINMLKKYSH-- 79 Query: 251 CPFIVCMSYAFHT------PDKLSFILDLMNGGDLHYHLS--QHGVFSEADMRFYAAEII 302 I AF D+L +++ G + + + E + + + EI+ Sbjct: 80 HRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREIL 139 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK--KKPHASVGTHGYMAPE 360 GL H+H V++RD+K N+LL E+ V++ D G++ + + + +GT +MAPE Sbjct: 140 RGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 199 Query: 361 VL----QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPD- 415 V+ YD +D +S G ++ G P D H + + L P Sbjct: 200 VIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLC-----DMHPMRALFLIPRNPPPRL 254 Query: 416 ---SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 +S + S +EG L ++ +R +++ + PF R Sbjct: 255 KSKKWSKKFFSFIEGCLVKNYMQR-----PSTEQLLKHPFIRD 292 >1G3N-A nrPDB Length = 326 Score = 225 bits (574), Expect = 5e-59, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 130/312 (41%), Gaps = 41/312 (13%) Query: 191 FSVHRIIGRGGFGEVYGCRK-ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + IG G +G+V+ R + G+ A+K + + + + + E +L + T Sbjct: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLETF 71 Query: 250 DCPFIVCMSYAF-----HTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADMRFYAAEII 302 + P +V + KL+ + + ++ DL +L + ++ +++ Sbjct: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLL 130 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEV 361 GL+ +H+ VV+RDLKP NIL+ G ++++D GLA +S + + V T Y APEV Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK--HEIDRMTLTMAVELPDSF-- 417 L + +Y + D +S+GC+ ++ R FR D+ +D + L + P Sbjct: 191 LLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVAL 249 Query: 418 ------SPEL--------------RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 S + LL L + +R+ P+F+ L+ Sbjct: 250 PRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS-----ALSHPYFQDLE 304 Query: 458 WQMVFLQKYPPP 469 L + PP Sbjct: 305 RCKENLDSHLPP 316 >3ZDU-A nrPDB Length = 325 Score = 225 bits (573), Expect = 5e-59, Method: Composition-based stats. Identities = 59/314 (18%), Positives = 120/314 (38%), Gaps = 40/314 (12%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 +M + +G G +G V C+ +TG++ A+K ++ + +A+ E + + Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERP--EQSVNKIAMRE---IKFL 55 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 +V + F K+ + + ++ L +R Y +I+ ++ Sbjct: 56 KQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAID 115 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQK 364 ++H+ +++RD+KP NIL+ + G ++ D G A V T Y APE++ K Sbjct: 116 YLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLK 175 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-KHEIDRMTLTMAVELPDSFSPE--- 420 +Y D ++LGCM+ ++ G+ D H+I ++ L + FS Sbjct: 176 DTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIF 235 Query: 421 ------------------------LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 L ++ LQ D R+ ++ +F Sbjct: 236 AGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSS-----DLLHHEYFTRD 290 Query: 457 DWQMVFLQKYPPPL 470 + F+ + L Sbjct: 291 GFIEKFMPELKAKL 304 >5H2U-A nrPDB Length = 267 Score = 225 bits (573), Expect = 6e-59, Method: Composition-based stats. Identities = 54/258 (20%), Positives = 106/258 (41%), Gaps = 15/258 (5%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + +F++ R +G G FGEV+ D + A+K + + + +Q + + Sbjct: 1 MERPREEFTLCRKLGSGYFGEVFEGLWKDRVQ-VAIKVISRDNLLHQQM------LQSEI 53 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADMRFYAAEI 301 + I+ + D + I +LM G L L V +++ A ++ Sbjct: 54 QAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQV 113 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVGTHGYMAP 359 G+ ++ ++ ++RDL NIL+ E+ ++ D GLA + H + + AP Sbjct: 114 AEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAP 173 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS 418 E L +G Y + +D +S G +L ++ G P+ + R+ + P Sbjct: 174 EALSRG-HYSTKSDVWSFGILLHEMFSRGQVPYPGMS--NHEAFLRVDAGYRMPCPLECP 230 Query: 419 PELRSLLEGLLQRDVNRR 436 P + L+ RD +R Sbjct: 231 PSVHKLMLTCWCRDPEQR 248 >5L6P-A nrPDB Length = 298 Score = 224 bits (572), Expect = 7e-59, Method: Composition-based stats. Identities = 55/257 (21%), Positives = 105/257 (40%), Gaps = 20/257 (7%) Query: 192 SVHRIIGRGGFGEVYGCRKADTGKM---YAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + +IG G FGEV R G+ A+K L + ++ + L+ S++ Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLS-----EASIMGQ 76 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLEH 307 D P I+ + + + + M L L + G F+ + I G+++ Sbjct: 77 FDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKY 136 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK----KPHASVG---THGYMAPE 360 + V+RDL NIL++ + ++SD GL+ +S+G + APE Sbjct: 137 LSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPE 196 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSP 419 + + S++D +S G ++++++ G P+ +D I+ + + P Sbjct: 197 AIAY-RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDV--INAVEQDYRLPPPMDCPT 253 Query: 420 ELRSLLEGLLQRDVNRR 436 L L+ RD N R Sbjct: 254 ALHQLMLDCWVRDRNLR 270 >6CCF-A nrPDB Length = 290 Score = 223 bits (569), Expect = 2e-58, Method: Composition-based stats. Identities = 75/294 (25%), Positives = 134/294 (45%), Gaps = 33/294 (11%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK--------------- 230 + +N + + IG+G +G V + YAMK L KK++ + Sbjct: 2 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 61 Query: 231 ----QGETLALNER-IMLSLVSTGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHL 283 + L L ++++ D +V + P D L + DL+ G + + Sbjct: 62 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-V 120 Query: 284 SQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS 343 FSE R Y ++ILGLE++H + +V+RD+KP+N+LL + GHV+I+D G++ F Sbjct: 121 PCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 180 Query: 344 KK--KPHASVGTHGYMAPEVLQK-GVAYDSSA-DWFSLGCMLFKLLRGHSPFRQHKTKDK 399 + ++ GT +MAPE + G ++ A D ++ G L+ + G PF Sbjct: 181 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 240 Query: 400 HEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 H + + E P+ S EL+ L+ +L ++ R+G ++K P+ Sbjct: 241 HRKIKNEPVVFPEEPE-ISEELKDLILKMLDKNPETRIG-----VPDIKLHPWV 288 >4UYA-A nrPDB Length = 340 Score = 223 bits (569), Expect = 2e-58, Method: Composition-based stats. Identities = 77/338 (22%), Positives = 142/338 (42%), Gaps = 35/338 (10%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 +H+ + +IG GGFG+VY G+ A+K ++ + A + R Sbjct: 21 VHVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKA--ARQDPEQDAAAAAESVRREA 76 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 L + P I+ + L +L+ GG L+ L+ + +A +I Sbjct: 77 RLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAGR-RIPPHVLVNWAVQIAR 135 Query: 304 GLEHMHNRF---VVYRDLKPANILLDE--------HGHVRISDLGLACDFSKKKPHASVG 352 G+ ++H +++RDLK +NILL E + ++I+D GLA ++ + A+ G Sbjct: 136 GMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAG 195 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE 412 + +MAPEV+ K + +D +S G +L++LL G P+R + + Sbjct: 196 AYAWMAPEVI-KSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGL-AVAYGVAVNKLTLP 253 Query: 413 LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 472 +P + L++ Q+D + R P F + Q+ ++ +P Sbjct: 254 IPSTCPEPFAKLMKECWQQDPHIR--------------PSFALILEQLTAIEGAVMTEMP 299 Query: 473 PRGEVNAADAFDIG---SFDEEDTKGIKLLDSDQELYR 507 + D + + FDE TK +L ++EL R Sbjct: 300 QESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTR 337 >3HKO-A nrPDB Length = 345 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 67/317 (21%), Positives = 116/317 (36%), Gaps = 58/317 (18%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + IG+G +G V + T + A+K ++K +I+ + + + L+ Sbjct: 28 YHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIR-QINPKDVERIKTEVRLMKKLH 86 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFS-------------------- 290 P I + + + +++L +GG L L+ S Sbjct: 87 HPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECN 146 Query: 291 --------------------EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHG- 329 E + +I L ++HN+ + +RD+KP N L + Sbjct: 147 EEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKS 206 Query: 330 -HVRISDLGLACDFSK------KKPHASVGTHGYMAPEVLQ-KGVAYDSSADWFSLGCML 381 +++ D GL+ +F K GT ++APEVL +Y D +S G +L Sbjct: 207 FEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLL 266 Query: 382 FKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS--FSPELRSLLEGLLQRDVNRRLGC 439 LL G PF D + + E P+ SP R LL LL R+V+ R Sbjct: 267 HLLLMGAVPFPGVNDADTISQV-LNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERF-- 323 Query: 440 LGRGAQEVKESPFFRSL 456 A + P+ Sbjct: 324 ---DAMRALQHPWISQF 337 >5X02-A nrPDB Length = 347 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 72/325 (22%), Positives = 127/325 (39%), Gaps = 50/325 (15%) Query: 168 SDKFTRFCQWKNVE--LNIHLTMNDFSVHRIIGRGGFGEV-----YGCRKADTGKMYAMK 220 SD + ++ E L + +++G G FG+V YG K A+K Sbjct: 25 SDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVK 84 Query: 221 CLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLH 280 L K++ + E L ++M L G IV + A + I + GDL Sbjct: 85 ML-KEKADSSEREALMSELKMMTQL---GSHENIVNLLGACTLSGPIYLIFEYCCYGDLL 140 Query: 281 YHLS-QHGVFSEADMRF----------------------YAAEIILGLEHMHNRFVVYRD 317 +L + FSE ++ + +A ++ G+E + + V+RD Sbjct: 141 NYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRD 200 Query: 318 LKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG----YMAPEVLQKGVAYDSSAD 373 L N+L+ V+I D GLA D + G +MAPE L +G+ Y +D Sbjct: 201 LAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGI-YTIKSD 259 Query: 374 WFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRD 432 +S G +L+++ G +P+ D + + ++ P + E+ +++ D Sbjct: 260 VWSYGILLWEIFSLGVNPYPGIPV-DANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFD 318 Query: 433 VNRR---------LGCLGRGAQEVK 448 +R LGC A+E Sbjct: 319 SRKRPSFPNLTSFLGCQLADAEEAM 343 >3CJF-A nrPDB Length = 309 Score = 222 bits (567), Expect = 3e-58, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 119/296 (40%), Gaps = 34/296 (11%) Query: 178 KNVELNIHLTMNDFSVHRIIGRGGFGEV-----YGCRKADTGKMYAMKCLDKKRIKMKQG 232 + ++ + +GRG FG+V +G K T + A+K L + + Sbjct: 16 PYDASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR 75 Query: 233 ETLALNERIMLSLVSTGDCPFIVCMSYAFHTPD-KLSFILDLMNGGDLHYHLSQHG---- 287 L +I++ + G +V + A P L I++ G+L +L Sbjct: 76 -ALMSELKILIHI---GHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFV 131 Query: 288 --------VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA 339 + + Y+ ++ G+E + +R ++RDL NILL E V+I D GLA Sbjct: 132 PYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 191 Query: 340 CDFSKKKPHASVGTHG----YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQH 394 D K + G +MAPE + V Y +D +S G +L+++ G SP+ Sbjct: 192 RDIYKDPDYVRKGDARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPGV 250 Query: 395 KTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKES 450 K D+ R+ + PD +PE+ + + ++R E+ E Sbjct: 251 KI-DEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQR-----PTFSELVEH 300 >5KKR-C nrPDB Length = 395 Score = 222 bits (566), Expect = 4e-58, Method: Composition-based stats. Identities = 70/359 (19%), Positives = 136/359 (37%), Gaps = 56/359 (15%) Query: 150 IEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCR 209 +E + + L + Q + V L +DF +G G G V+ Sbjct: 32 LEALQKKLEELELDEQQRKRLEAFLTQKQKVG---ELKDDDFEKISELGAGNGGVVFKVS 88 Query: 210 KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSF 269 +G + A K + ++ + L ++ + P+IV AF++ ++S Sbjct: 89 HKPSGLVMARKLI-----HLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISI 143 Query: 270 ILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM-HNRFVVYRDLKPANILLDEH 328 ++ M+GG L L + G E + + +I GL ++ +++RD+KP+NIL++ Sbjct: 144 CMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSR 203 Query: 329 GHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGH 388 G +++ D G++ ++ VGT YM+PE LQ G Y +D +S+G L ++ G Sbjct: 204 GEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ-GTHYSVQSDIWSMGLSLVEMAVGR 262 Query: 389 SPFRQHKTKDK----------------------------------------HEIDRMTLT 408 P K+ +D + Sbjct: 263 YPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNE 322 Query: 409 MAVELPDS-FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKY 466 +LP + FS E + + L ++ R +++ F + D + V + Sbjct: 323 PPPKLPSAVFSLEFQDFVNKCLIKNPAER-----ADLKQLMVHAFIKRSDAEEVDFAGW 376 >5EFQ-A nrPDB Length = 347 Score = 222 bits (566), Expect = 4e-58, Method: Composition-based stats. Identities = 68/326 (20%), Positives = 129/326 (39%), Gaps = 56/326 (17%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 ++ F + IIG G +G+VY R DTG+M A+K + + E + + ++ Sbjct: 10 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDN----EKEGFPITAIREIKILR 65 Query: 248 TGDCPFIVCMSYAFHTPDK----------LSFILDLMNGGDLHYHLSQH-GVFSEADMRF 296 I+ M + + + M+ DL L F+E ++ Sbjct: 66 QLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFNENHIKS 124 Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK---PHASVGT 353 + +++ GL++ H + ++RD+K +NILL+ G ++++D GLA +S ++ V T Sbjct: 125 FMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVIT 184 Query: 354 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE- 412 Y PE+L Y + D +S GC+L +L F+ ++ + E+ Sbjct: 185 LWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPA 244 Query: 413 -LPD-------------------------SFSPELRSLLEGLLQRDVNRRLGCLGRGAQE 446 PD L + +L D ++R A++ Sbjct: 245 VWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKR-----CTAEQ 299 Query: 447 VKESPFFRSLDWQMVFLQKYPPPLIP 472 + F R ++ + PPP +P Sbjct: 300 ALQCEFLRDVEPSKM-----PPPDLP 320 >3OZ6-A nrPDB Length = 388 Score = 222 bits (566), Expect = 4e-58, Method: Composition-based stats. Identities = 68/333 (20%), Positives = 124/333 (37%), Gaps = 79/333 (23%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + + +G+G +G V+ TG++ A+K + + I+ L Sbjct: 11 YELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTEL---SG 67 Query: 251 CPFIVCMSYAFH--TPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 IV + + + D M DLH + + + ++ ++I ++++ Sbjct: 68 HENIVNLLNVLRADNDRDVYLVFDYMET-DLHAVIRAN-ILEPVHKQYVVYQLIKVIKYL 125 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLAC---------------------DFSKKKP 347 H+ +++RD+KP+NILL+ HV+++D GL+ +F +P Sbjct: 126 HSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQP 185 Query: 348 --HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKT--------- 396 V T Y APE+L Y D +SLGC+L ++L G F T Sbjct: 186 ILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERIIG 245 Query: 397 -------------------------KDKHEIDR----------MTLTMAVELPDSFSPEL 421 K+K EI + L + + + E Sbjct: 246 VIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEEA 305 Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 LL+ LLQ + N+R+ A + + PF Sbjct: 306 LDLLDKLLQFNPNKRI-----SANDALKHPFVS 333 >1UA2-A nrPDB Length = 346 Score = 222 bits (565), Expect = 4e-58, Method: Composition-based stats. Identities = 71/306 (23%), Positives = 130/306 (42%), Gaps = 39/306 (12%) Query: 180 VELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 239 + L++ + +G G F VY R +T ++ A+K + + + + + Sbjct: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGH-RSEAKDGINRTA 59 Query: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYA 298 + L+ P I+ + AF +S + D M DL + + V + + ++ Y Sbjct: 60 LREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYM 118 Query: 299 AEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK--KKPHASVGTHGY 356 + GLE++H ++++RDLKP N+LLDE+G ++++D GLA F + V T Y Sbjct: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE---- 412 APE+L Y D +++GC+L +LL PF D ++ R+ T+ Sbjct: 179 RAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFL-PGDSDLDQLTRIFETLGTPTEEQ 236 Query: 413 LPDSFS-----------------------PELRSLLEGLLQRDVNRRLGCLGRGAQEVKE 449 PD S +L L++GL + R+ A + + Sbjct: 237 WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALK 291 Query: 450 SPFFRS 455 +F + Sbjct: 292 MKYFSN 297 >2J0K-A nrPDB Length = 656 Score = 222 bits (565), Expect = 5e-58, Method: Composition-based stats. Identities = 61/263 (23%), Positives = 108/263 (41%), Gaps = 17/263 (6%) Query: 182 LNIHLTMNDFSVHRIIGRGGFGEVYGCRK---ADTGKMYAMKCLDKKRIKMKQGETLALN 238 + + + R IG G FG+V+ + A+K K L Sbjct: 383 RDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKT--CKNCTSDSVREKFLQ 440 Query: 239 ERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFY 297 E + + D P IV + T + + I++L G+L L A + Y Sbjct: 441 EAL---TMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKFSLDLASLILY 496 Query: 298 AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH-ASVG--TH 354 A ++ L ++ ++ V+RD+ N+L+ V++ D GL+ + AS G Sbjct: 497 AYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPI 556 Query: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFK-LLRGHSPFRQHKTKDKHEIDRMTLTMAVEL 413 +MAPE + + S++D + G +++ L+ G PF+ K D I R+ + + Sbjct: 557 KWMAPESINFRR-FTSASDVWMFGVCMWEILMHGVKPFQGVKNNDV--IGRIENGERLPM 613 Query: 414 PDSFSPELRSLLEGLLQRDVNRR 436 P + P L SL+ D +RR Sbjct: 614 PPNCPPTLYSLMTKCWAYDPSRR 636 >3GC0-A nrPDB Length = 329 Score = 222 bits (565), Expect = 5e-58, Method: Composition-based stats. Identities = 63/307 (20%), Positives = 119/307 (38%), Gaps = 44/307 (14%) Query: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 +++ + +G G +GEVY T + A+K + + + E + +SL+ Sbjct: 32 SIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEH----EEEGVPGTAIREVSLL 87 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 I+ + H +L I + DL ++ ++ S ++ + ++I G+ Sbjct: 88 KELQHRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVN 146 Query: 307 HMHNRFVVYRDLKPANILL-----DEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAP 359 H+R ++RDLKP N+LL E ++I D GLA F ++ + T Y P Sbjct: 147 FCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPP 206 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE------- 412 E+L Y +S D +S+ C+ ++L F D+ L + + Sbjct: 207 EILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVT 266 Query: 413 --------LPDSFSPELRSLL------------EGLLQRDVNRRLGCLGRGAQEVKESPF 452 P L+ +L +L+ D +R+ A+ E P+ Sbjct: 267 ALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRI-----SAKNALEHPY 321 Query: 453 FRSLDWQ 459 F D+ Sbjct: 322 FSHNDFD 328 >5Z33-A nrPDB Length = 425 Score = 221 bits (563), Expect = 1e-57, Method: Composition-based stats. Identities = 68/303 (22%), Positives = 119/303 (39%), Gaps = 49/303 (16%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 ++V + +G+G +G V T + A+K + + + LA + L+ Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKV----TNVFSKKILAKRALREIKLLQH 86 Query: 249 GD-CPFIVCMSYA-FHTPDKL---SFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 I C+ PD +LM DL + ++A + + +I+ Sbjct: 87 FRGHRNITCLYDMDIPRPDNFNETYLYEELME-CDLAAIIRSGQPLTDAHFQSFIYQILC 145 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK------PHASVGTHGYM 357 GL+++H+ V++RDLKP N+L++ ++I D GLA FS V T Y Sbjct: 146 GLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYR 205 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE----- 412 APE++ +Y + D +S+GC+L +LL G F+ D+ L E Sbjct: 206 APEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSR 265 Query: 413 --------------------LPDSFS---PELRSLLEGLLQRDVNRRLGCLGRGAQEVKE 449 P F P+ LL+ +L D + R+ ++ E Sbjct: 266 IGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRI-----SVEQALE 320 Query: 450 SPF 452 P+ Sbjct: 321 HPY 323 >4H1J-A nrPDB Length = 293 Score = 221 bits (562), Expect = 1e-57, Method: Composition-based stats. Identities = 58/262 (22%), Positives = 107/262 (40%), Gaps = 17/262 (6%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCR---KADTGKMYAMKCLDKKRIKMKQGETLALNE 239 + D ++RI+G G FGEVY A+K KK + E Sbjct: 18 QYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKT-CKKDCTLDNKEKFMSEA 76 Query: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYA 298 IM +L D P IV + I++L G+L ++L ++ + Y+ Sbjct: 77 VIMKNL----DHPHIVKLIGIIEEEPT-WIIMELYPYGELGHYLERNKNSLKVLTLVLYS 131 Query: 299 AEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---G 355 +I + ++ + V+RD+ NIL+ V++ D GL+ + + + T Sbjct: 132 LQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIK 191 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELP 414 +M+PE + + +++D + ++++L G PF + KD I + + P Sbjct: 192 WMSPESINFRR-FTTASDVWMFAVCMWEILSFGKQPFFWLENKDV--IGVLEKGDRLPKP 248 Query: 415 DSFSPELRSLLEGLLQRDVNRR 436 D P L +L+ D + R Sbjct: 249 DLCPPVLYTLMTRCWDYDPSDR 270 >3EQC-A nrPDB Length = 360 Score = 221 bits (562), Expect = 1e-57, Method: Composition-based stats. Identities = 66/324 (20%), Positives = 126/324 (38%), Gaps = 53/324 (16%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 L +DF +G G G V+ +G + A K + ++ + L Sbjct: 29 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLI-----HLEIKPAIRNQIIRELQ 83 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 ++ + P+IV AF++ ++S ++ M+GG L L + G E + + +I G Sbjct: 84 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 143 Query: 305 LEHM-HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 363 L ++ +++RD+KP+NIL++ G +++ D G++ ++ VGT YM+PE LQ Sbjct: 144 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ 203 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK------------------------ 399 G Y +D +S+G L ++ G P K+ Sbjct: 204 -GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 262 Query: 400 ----------------HEIDRMTLTMAVELPDS-FSPELRSLLEGLLQRDVNRRLGCLGR 442 +D + +LP FS E + + L ++ R Sbjct: 263 PLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER-----A 317 Query: 443 GAQEVKESPFFRSLDWQMVFLQKY 466 +++ F + D + V + Sbjct: 318 DLKQLMVHAFIKRSDAEEVDFAGW 341 >1U5R-A nrPDB Length = 348 Score = 220 bits (561), Expect = 2e-57, Method: Composition-based stats. Identities = 57/265 (21%), Positives = 100/265 (37%), Gaps = 13/265 (4%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 FS R IG G FG VY R ++ A+K + KQ + + + Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSY---SGKQSNEKWQDIIKEVRFLQKLR 112 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P + + +++ G E ++ + GL ++H+ Sbjct: 113 HPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHS 172 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL--QKGVAY 368 +++RD+K NILL E G V++ D G A + ++ VGT +MAPEV+ Y Sbjct: 173 HNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP--ANSFVGTPYWMAPEVILAMDEGQY 230 Query: 369 DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGL 428 D D +SLG +L P + A++ +S R+ ++ Sbjct: 231 DGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQ-SGHWSEYFRNFVDSC 289 Query: 429 LQRDVNRRLGCLGRGAQEVKESPFF 453 LQ+ R ++ + + F Sbjct: 290 LQKIPQDR-----PTSEVLLKHRFV 309 >4E93-A nrPDB Length = 377 Score = 220 bits (561), Expect = 2e-57, Method: Composition-based stats. Identities = 60/257 (23%), Positives = 104/257 (40%), Gaps = 14/257 (5%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 L D + IGRG FGEV+ R + A+K + + L E +L Sbjct: 111 LNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK--SCRETLPPDLKAKFLQEARILKQ 168 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIILG 304 S P IV + + +++L+ GGD L G + + G Sbjct: 169 YS---HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 225 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH----GYMAPE 360 +E++ ++ ++RDL N L+ E ++ISD G++ + + AS G + APE Sbjct: 226 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 285 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSP 419 L G Y S +D +S G +L++ G SP+ + E + + P+ Sbjct: 286 ALNYGR-YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREF--VEKGGRLPCPELCPD 342 Query: 420 ELRSLLEGLLQRDVNRR 436 + L+E + +R Sbjct: 343 AVFRLMEQCWAYEPGQR 359 >6GQK-A nrPDB Length = 328 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 60/293 (20%), Positives = 108/293 (36%), Gaps = 33/293 (11%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGC-----RKADTGKMYAMKCLDKKRIKMKQGETLAL 237 N S + +G G FG+V K+D A+K L K + E L Sbjct: 35 KWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKML-KPSAHSTEREALMS 93 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG---------- 287 +++ L G+ IV + A I + GDL L + Sbjct: 94 ELKVLSYL---GNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAP 150 Query: 288 ------VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD 341 + + ++ ++ G+ + ++ ++RDL NILL +I D GLA D Sbjct: 151 EDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARD 210 Query: 342 FSKKKPHASVGTHG----YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKT 396 + G +MAPE + V Y +D +S G L++L G SP+ Sbjct: 211 IKNDSNYVDKGNARLPVKWMAPESIFNSV-YTFESDVWSYGIFLWELFSLGSSPYPGMPV 269 Query: 397 KDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKE 449 D + + P+ E+ +++ D ++R + Q++++ Sbjct: 270 -DSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPT-FKQIVQDIEK 320 >4NST-A nrPDB Length = 351 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 64/322 (19%), Positives = 126/322 (39%), Gaps = 51/322 (15%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 ++ F + IIG G +G+VY + DTG++ A+K + + E + + ++ Sbjct: 12 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDN----EKEGFPITAIREIKILR 67 Query: 248 TGDCPFIVCMSYAFHTPDK----------LSFILDLMNGGDLHYHLSQH-GVFSEADMRF 296 +V M + + M+ DL L FSE ++ Sbjct: 68 QLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFSEDHIKS 126 Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK---PHASVGT 353 + +++ GLE+ H + ++RD+K +NILL+ G ++++D GLA ++ ++ V T Sbjct: 127 FMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVIT 186 Query: 354 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQH-KTKDKHEIDRMTLTMAVE 412 Y PE+L Y + D +S GC+L +L F+ + + I R+ + Sbjct: 187 LWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPA 246 Query: 413 LPDS--------------------------FSPELRSLLEGLLQRDVNRRLGCLGRGAQE 446 + LL+ +L D ++R A++ Sbjct: 247 VWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKR-----CTAEQ 301 Query: 447 VKESPFFRSLDWQMVFLQKYPP 468 +S F + ++ + P Sbjct: 302 TLQSDFLKDVELSKMAPPDLPH 323 >2GCD-A nrPDB Length = 309 Score = 219 bits (558), Expect = 4e-57, Method: Composition-based stats. Identities = 57/265 (21%), Positives = 100/265 (37%), Gaps = 13/265 (4%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 FS R IG G FG VY R ++ A+K + KQ + + + Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSY---SGKQSNEKWQDIIKEVRFLQKLR 73 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P + + +++ G E ++ + GL ++H+ Sbjct: 74 HPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHS 133 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL--QKGVAY 368 +++RD+K NILL E G V++ D G A + ++ VGT +MAPEV+ Y Sbjct: 134 HNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP--ANSFVGTPYWMAPEVILAMDEGQY 191 Query: 369 DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGL 428 D D +SLG +L P + A++ +S R+ ++ Sbjct: 192 DGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQ-SGHWSEYFRNFVDSC 250 Query: 429 LQRDVNRRLGCLGRGAQEVKESPFF 453 LQ+ R ++ + + F Sbjct: 251 LQKIPQDR-----PTSEVLLKHRFV 270 >5X5O-A nrPDB Length = 310 Score = 219 bits (557), Expect = 4e-57, Method: Composition-based stats. Identities = 52/258 (20%), Positives = 102/258 (39%), Gaps = 21/258 (8%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + + +D G G FG VY + K A+K L L Sbjct: 10 VQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL--------------LKIEKEA 55 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEI 301 ++S I+ P + + + G L+ +++ + + +A ++ Sbjct: 56 EILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDV 115 Query: 302 ILGLEHMHNR---FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMA 358 G+ ++H V++RDLK N+++ G ++I D G + + + VGT +MA Sbjct: 116 AKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMA 175 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS 418 PEV+Q + + D +S G +L+++L PF+ + + + + +P S Sbjct: 176 PEVIQ-SLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLV-VEKNERLTIPSSCP 233 Query: 419 PELRSLLEGLLQRDVNRR 436 LL + D +R Sbjct: 234 RSFAELLHQCWEADAKKR 251 >4QNY-A nrPDB Length = 354 Score = 219 bits (557), Expect = 4e-57, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 127/304 (41%), Gaps = 45/304 (14%) Query: 189 NDFSVHRIIGRGGFGEVYGCRK-ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + + + RIIG G +G V R ++ AMK ++K+ + LA + L++ Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIF---EEVILAKRILREIKLLA 76 Query: 248 TGDCPFIVCMSYAF-----HTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 + I+ + D ++D+M DL L +EA ++F+ + + Sbjct: 77 HFNDDNIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVLRSGQELTEAHIQFFIYQAL 135 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH--ASVGTHGYMAPE 360 L +H+ V++RD+ PANIL++ + ++I D GLA + + + + V Y APE Sbjct: 136 RALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPE 195 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSF-- 417 ++ + Y + D + +GC+L +LL F+ ++ +I + T + E +S Sbjct: 196 LVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGS 255 Query: 418 -------------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPF 452 SPE LL +L + RR+ L + PF Sbjct: 256 SAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVL-----QAMRHPF 310 Query: 453 FRSL 456 L Sbjct: 311 LEQL 314 >4O2Z-A nrPDB Length = 377 Score = 219 bits (557), Expect = 4e-57, Method: Composition-based stats. Identities = 65/300 (21%), Positives = 126/300 (42%), Gaps = 39/300 (13%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + +++ +I+G G +G C DTG+ ++K + + + L E M+ Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKK-CRDVFRDVEDGKRVLREIDMMRFFHH 103 Query: 249 GDCPFIVC----MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 + +V + +H+ + + + LM+ D++ L V E+ M+++ +I+ G Sbjct: 104 ENLLNVVNILPPLKREYHSFEDVYVVTPLMD-VDMNVVLRSRQVLEESHMQYFVYQILRG 162 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC--DFSKKKPHASVGTHGYMAPEVL 362 L+++H+ V +RDLKPAN++ + ++I D GL+ D + V T Y PE+L Sbjct: 163 LKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELL 222 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEID--------------RMTLT 408 + Y ++ D +S+GC+ ++ F T D+ + R L Sbjct: 223 LENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREALE 282 Query: 409 MAVELPD---SFS---------PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 ELPD + E L + D ++R A ++ P+ L Sbjct: 283 KLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKR-----PTAADMLAHPYLAHL 337 >4XUF-A nrPDB Length = 297 Score = 218 bits (556), Expect = 6e-57, Method: Composition-based stats. Identities = 64/289 (22%), Positives = 116/289 (40%), Gaps = 39/289 (13%) Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEV-----YGCRKADTGKMYAMKCLDKKRIKMKQGETL 235 +L + +++G G FG+V YG K A+K L K++ + E L Sbjct: 1 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKML-KEKADSSEREAL 59 Query: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADM 294 ++M L G IV + A + I + GDL +L + FSE ++ Sbjct: 60 MSELKMMTQL---GSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEI 116 Query: 295 RF----------------------YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVR 332 + +A ++ G+E + + V+RDL N+L+ V+ Sbjct: 117 EYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVK 176 Query: 333 ISDLGLACDFSKKKPHASVGTHG----YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-G 387 I D GLA D + G +MAPE L +G+ Y +D +S G +L+++ G Sbjct: 177 ICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGI-YTIKSDVWSYGILLWEIFSLG 235 Query: 388 HSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 +P+ D + + ++ P + E+ +++ D +R Sbjct: 236 VNPYPGIPV-DANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKR 283 >6CQF-A nrPDB Length = 297 Score = 218 bits (556), Expect = 6e-57, Method: Composition-based stats. Identities = 57/269 (21%), Positives = 116/269 (43%), Gaps = 12/269 (4%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + + + +G G +GEV+ R +G + A+K + ++ + E + ++ T Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK---MEPDDDVSTLQKEIL---ILKT 69 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 IV ++ KL ++ G L G SE + + E++ GL ++ Sbjct: 70 CRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYL 129 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH--ASVGTHGYMAPEV--LQK 364 H++ ++RD+K ANIL+++ G VR++D G++ A +GT +MAPEV + Sbjct: 130 HSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVAL 189 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSP-FRQHKTKDKHEIDRMTL-TMAVELPDSFSPELR 422 Y+ D +SLG +L P F H + + + ++ +S Sbjct: 190 KGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFH 249 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESP 451 + ++ L + +R + ++ P Sbjct: 250 NFIKVTLTKSPKKRPSATKMLSHQLVSQP 278 >3BGP-A nrPDB Length = 333 Score = 217 bits (554), Expect = 1e-56, Method: Composition-based stats. Identities = 63/274 (22%), Positives = 115/274 (41%), Gaps = 22/274 (8%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI----KMKQGETLALNERIMLS 244 + + V ++G GGFG VY + A+K ++K RI ++ G + + ++ Sbjct: 56 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 115 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNG-GDLHYHLSQHGVFSEADMRFYAAEIIL 303 + S ++ + F PD IL+ DL +++ G E R + +++ Sbjct: 116 VSSGFSG--VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 173 Query: 304 GLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL 362 + H HN V++RD+K NIL+D G +++ D G GT Y PE + Sbjct: 174 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI 233 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 + + SA +SLG +L+ ++ G PF EI R + S E + Sbjct: 234 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-----EEIIRGQVFFR----QRVSSECQ 284 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 L+ L + R +E++ P+ + + Sbjct: 285 HLIRWCLALRPSDR-----PTFEEIQNHPWMQDV 313 >4XLV-A nrPDB Length = 328 Score = 217 bits (553), Expect = 1e-56, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 123/305 (40%), Gaps = 31/305 (10%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYG--CRKADTGK---MYAMKCLDKKRIKMKQGETLAL 237 ++ ++ R +G+G FG VY R G+ A+K +++ ++ E L Sbjct: 33 EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFL-- 90 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ----------HG 287 S++ C +V + +++LM GDL +L Sbjct: 91 ---NEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRP 147 Query: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 347 + +M AAEI G+ +++ + V+RDL N ++ V+I D G+ D + Sbjct: 148 PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDY 207 Query: 348 HASVG----THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEI 402 + G +MAPE L+ GV + +S+D +S G +L+++ P++ + + Sbjct: 208 YRKGGKGLLPVRWMAPESLKDGV-FTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKF 266 Query: 403 DRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKE--SPFFRSLDWQM 460 + ++ PD+ + L+ Q + N R L +K+ P F + + Sbjct: 267 --VMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFL-EIVNLLKDDLHPSFPEVSFFH 323 Query: 461 VFLQK 465 K Sbjct: 324 SEENK 328 >1K9A-A nrPDB Length = 450 Score = 217 bits (553), Expect = 1e-56, Method: Composition-based stats. Identities = 53/273 (19%), Positives = 109/273 (39%), Gaps = 20/273 (7%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 L M + + + IG+G FG+V G A+KC+ + A Sbjct: 188 WALNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIK--------NDATAQAFLAEA 237 Query: 244 SLVSTGDCPFIVCMSYAF-HTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAE 300 S+++ +V + L + + M G L +L G + ++ + Sbjct: 238 SVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 297 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE 360 + +E++ V+RDL N+L+ E ++SD GL + S + + + APE Sbjct: 298 VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-PVKWTAPE 356 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSP 419 L++ + + +D +S G +L+++ G P+ + KD + R+ ++ PD P Sbjct: 357 ALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV--VPRVEKGYKMDAPDGCPP 413 Query: 420 ELRSLLEGLLQRDVNRR--LGCLGRGAQEVKES 450 + +++ D R L + ++ Sbjct: 414 AVYDVMKNCWHLDAATRPTFLQLREQLEHIRTH 446 >3GC9-A nrPDB Length = 370 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 70/322 (21%), Positives = 129/322 (40%), Gaps = 56/322 (17%) Query: 194 HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPF 253 R +G G +G V A + A+K L + Q A L L+ Sbjct: 33 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSR----PFQSLIHARRTYRELRLLKHLKHEN 88 Query: 254 IVCMSYAF------HTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 ++ + F ++ + LM G DL+ + + S+ ++F +++ GL++ Sbjct: 89 VIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNN-IVKSQALSDEHVQFLVYQLLRGLKY 146 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVA 367 +H+ +++RDLKP+N+ ++E +RI D GLA + ++ V T Y APE++ + Sbjct: 147 IHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQ-ADEEMTGYVATRWYRAPEIMLNWMH 205 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSFS-------- 418 Y+ + D +S+GC++ +LL+G + F D+ + I + T + E+ S Sbjct: 206 YNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYI 265 Query: 419 -------------------PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQ 459 P LL +L D ++R+ A E +F Sbjct: 266 QSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAHAYFS----- 315 Query: 460 MVFLQKYPPPLIPPRGEVNAAD 481 +Y P P E Sbjct: 316 -----QYHDPEDEPEAEPYDES 332 >5TUR-A nrPDB Length = 404 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 63/274 (22%), Positives = 115/274 (41%), Gaps = 22/274 (8%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI----KMKQGETLALNERIMLS 244 + + V ++G GGFG VY + A+K ++K RI ++ G + + ++ Sbjct: 127 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 186 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNG-GDLHYHLSQHGVFSEADMRFYAAEIIL 303 + S ++ + F PD IL+ DL +++ G E R + +++ Sbjct: 187 VSSGFSG--VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 244 Query: 304 GLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL 362 + H HN V++RD+K NIL+D G +++ D G GT Y PE + Sbjct: 245 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI 304 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 + + SA +SLG +L+ ++ G PF EI R + S E + Sbjct: 305 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-----EEIIRGQVFFR----QRVSSECQ 355 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 L+ L + R +E++ P+ + + Sbjct: 356 HLIRWCLALRPSDR-----PTFEEIQNHPWMQDV 384 >3ALO-A nrPDB Length = 327 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 67/290 (23%), Positives = 125/290 (43%), Gaps = 29/290 (10%) Query: 180 VELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 239 E + T D IGRG +G V +G++ A+K + + + K+ + L ++ Sbjct: 13 PEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRI-RSTVDEKEQKQLLMDL 71 Query: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVF----SEADMR 295 ++ + + DCP+IV A ++LM+ ++ + V E + Sbjct: 72 DVV---MRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILG 128 Query: 296 FYAAEIILGLEHM-HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGT 353 + L H+ N +++RD+KP+NILLD G++++ D G++ G Sbjct: 129 KITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGC 188 Query: 354 HGYMAPEVLQ---KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA 410 YMAPE + YD +D +SLG L++L G P+ + + D++T + Sbjct: 189 RPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSV----FDQLTQVVK 244 Query: 411 VELPD-------SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 + P FSP + + L +D ++R +E+ + PF Sbjct: 245 GDPPQLSNSEEREFSPSFINFVNLCLTKDESKR-----PKYKELLKHPFI 289 >5NGU-A nrPDB Length = 381 Score = 216 bits (549), Expect = 3e-56, Method: Composition-based stats. Identities = 59/320 (18%), Positives = 113/320 (35%), Gaps = 51/320 (15%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 ++ IG G +G V A+K + + +T + ++ Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-----PFEHQTYCQRTLREIKILLRF 97 Query: 250 DCPFIVCMSYAFHTP-----DKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 I+ ++ P + + DLM DL+ L + S + ++ +I+ G Sbjct: 98 RHENIIGINDIIRAPTIEQMKDVYIVQDLMET-DLYKLL-KTQHLSNDHICYFLYQILRG 155 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA-----SVGTHGYMAP 359 L+++H+ V++RDLKP+N+LL+ ++I D GLA H V T Y AP Sbjct: 156 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 215 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE------------------ 401 E++ Y S D +S+GC+L ++L F D+ Sbjct: 216 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 275 Query: 402 ----------IDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESP 451 + L + + LL+ +L + ++R+ ++ P Sbjct: 276 NLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI-----EVEQALAHP 330 Query: 452 FFRSLDWQMVFLQKYPPPLI 471 + + P Sbjct: 331 YLEQY-YDPSDEPIAEAPFK 349 >2XNP-A nrPDB Length = 279 Score = 216 bits (549), Expect = 3e-56, Method: Composition-based stats. Identities = 70/279 (25%), Positives = 118/279 (42%), Gaps = 27/279 (9%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 D+ V IG G +G R+ GK+ K LD + + + L ++L+ Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSE----VNLLRE 61 Query: 249 GDCPFIVCMSYAF--HTPDKLSFILDLMNGGDLHYHLSQ----HGVFSEADMRFYAAEII 302 P IV T L +++ GGDL +++ E + ++ Sbjct: 62 LKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121 Query: 303 LGLEHMHNRF-----VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--HASVGTHG 355 L L+ H R V++RDLKPAN+ LD +V++ D GLA + VGT Sbjct: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPY 181 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPD 415 YM+PE ++Y+ +D +SLGC+L++L PF K+ ++ +P Sbjct: 182 YMSPE-QMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELA--GKIREGKFRRIPY 238 Query: 416 SFSPELRSLLEGLLQ-RDVNRRLGCLGRGAQEVKESPFF 453 +S EL ++ +L +D +E+ E+P Sbjct: 239 RYSDELNEIITRMLNLKD------YHRPSVEEILENPLI 271 >3KUL-B nrPDB Length = 325 Score = 216 bits (549), Expect = 4e-56, Method: Composition-based stats. Identities = 57/291 (19%), Positives = 108/291 (37%), Gaps = 27/291 (9%) Query: 165 FIESDKFTRFCQWKNVE---------LNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGK 215 F +F + + + + +IIG G GEV R G+ Sbjct: 16 FQGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQ 75 Query: 216 M---YAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILD 272 A+K L + ++ + L+ S++ D P I+ + + + Sbjct: 76 RDVPVAIKALKAGYTERQRRDFLS-----EASIMGQFDHPNIIRLEGVVTRGRLAMIVTE 130 Query: 273 LMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHV 331 M G L L H G F+ + + G+ ++ + V+RDL N+L+D + Sbjct: 131 YMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVC 190 Query: 332 RISDLGLACDFSKKKPHASVGT-----HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR 386 ++SD GL+ A T + APE + + S++D +S G +++++L Sbjct: 191 KVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAF-RTFSSASDVWSFGVVMWEVLA 249 Query: 387 -GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 G P+ +D I + + P L L+ +D +R Sbjct: 250 YGERPYWNMTNRDV--ISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQR 298 >5AIR-A nrPDB Length = 430 Score = 216 bits (549), Expect = 4e-56, Method: Composition-based stats. Identities = 73/304 (24%), Positives = 123/304 (40%), Gaps = 54/304 (17%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMK-CLDKKRIKMKQGETLALNERIMLSLVSTG 249 ++ ++IG G FG VY + D+G++ A+K L KR K ++ L ++ Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRE-----------LQIMRKL 114 Query: 250 DCPFIVCMSYAFHTPDK------LSFILDLMN---GGDLHYHLSQHGVFSEADMRFYAAE 300 D IV + Y F++ + L+ +LD + ++ ++ Y + Sbjct: 115 DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 174 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHV-RISDLGLACDFSKKKPHAS-VGTHGYMA 358 + L ++H+ + +RD+KP N+LLD V ++ D G A + +P+ S + + Y A Sbjct: 175 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 234 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-------------HEIDRM 405 PE++ Y SS D +S GC+L +LL G F D+ +I M Sbjct: 235 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 294 Query: 406 TLTM-AVELP------------DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPF 452 + P PE +L LL+ RL L A F Sbjct: 295 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA-----HSF 349 Query: 453 FRSL 456 F L Sbjct: 350 FDEL 353 >1BYG-A nrPDB Length = 278 Score = 216 bits (549), Expect = 4e-56, Method: Composition-based stats. Identities = 54/273 (19%), Positives = 109/273 (39%), Gaps = 20/273 (7%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 L M + + + IG+G FG+V G A+KC+ + A Sbjct: 16 WALNMKELKLLQTIGKGEFGDVMLG--DYRGNKVAVKCIK--------NDATAQAFLAEA 65 Query: 244 SLVSTGDCPFIVCMSYAF-HTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAE 300 S+++ +V + L + + M G L +L G + ++ + Sbjct: 66 SVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD 125 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE 360 + +E++ V+RDL N+L+ E ++SD GL + S + + + APE Sbjct: 126 VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-PVKWTAPE 184 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSP 419 L++ + + +D +S G +L+++ G P+ + KD + R+ ++ PD P Sbjct: 185 ALRE-KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV--VPRVEKGYKMDAPDGCPP 241 Query: 420 ELRSLLEGLLQRDVNRR--LGCLGRGAQEVKES 450 + +++ D R L + +K Sbjct: 242 AVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTH 274 >4RC3-A nrPDB Length = 289 Score = 216 bits (549), Expect = 4e-56, Method: Composition-based stats. Identities = 63/274 (22%), Positives = 115/274 (41%), Gaps = 22/274 (8%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI----KMKQGETLALNERIMLS 244 + + V ++G GGFG VY + A+K ++K RI ++ G + + ++ Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 71 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNG-GDLHYHLSQHGVFSEADMRFYAAEIIL 303 + S ++ + F PD IL+ DL +++ G E R + +++ Sbjct: 72 VSSGFSG--VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 129 Query: 304 GLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL 362 + H HN V++RD+K NIL+D G +++ D G GT Y PE + Sbjct: 130 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI 189 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 + + SA +SLG +L+ ++ G PF EI R + S E + Sbjct: 190 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-----EEIIRGQVFFR----QRVSSECQ 240 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 L+ L + R +E++ P+ + + Sbjct: 241 HLIRWCLALRPSDR-----PTFEEIQNHPWMQDV 269 >4PDO-A nrPDB Length = 299 Score = 215 bits (548), Expect = 5e-56, Method: Composition-based stats. Identities = 54/257 (21%), Positives = 105/257 (40%), Gaps = 21/257 (8%) Query: 192 SVHRIIGRGGFGEVYGCRKA-DTGKM---YAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + ++IG G FGEVY +GK A+K L + ++ + L ++ Sbjct: 37 TRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLG-----EAGIMG 91 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLE 306 I+ + + I + M G L L + G FS + I G++ Sbjct: 92 QFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMK 151 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK--PHASVG---THGYMAPEV 361 ++ N V+RDL NIL++ + ++SD GL+ + + G + APE Sbjct: 152 YLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEA 211 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTL-TMAVELPDSFSP 419 + + S++D +S G ++++++ G P+ + HE+ + + P Sbjct: 212 ISY-RKFTSASDVWSFGIVMWEVMTYGERPYWELSN---HEVMKAINDGFRLPTPMDCPS 267 Query: 420 ELRSLLEGLLQRDVNRR 436 + L+ Q++ RR Sbjct: 268 AIYQLMMQCWQQERARR 284 >2H8H-A nrPDB Length = 535 Score = 215 bits (547), Expect = 6e-56, Method: Composition-based stats. Identities = 55/260 (21%), Positives = 103/260 (39%), Gaps = 18/260 (6%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 + + +G+G FGEV+ T + A+K L + E ++M Sbjct: 261 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP---EAFLQEAQVM 316 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH--GVFSEADMRFYAAE 300 L +V + YA + + + + + M+ G L L + AA+ Sbjct: 317 KKL----RHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 371 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG---THGYM 357 I G+ ++ V+RDL+ ANIL+ E+ +++D GLA + A G + Sbjct: 372 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 431 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 APE G + +D +S G +L +L G P+ ++ +D++ + P Sbjct: 432 APEAALYGR-FTIKSDVWSFGILLTELTTKGRVPYPGMVNREV--LDQVERGYRMPCPPE 488 Query: 417 FSPELRSLLEGLLQRDVNRR 436 L L+ +++ R Sbjct: 489 CPESLHDLMCQCWRKEPEER 508 >3ZBF-A nrPDB Length = 322 Score = 215 bits (547), Expect = 6e-56, Method: Composition-based stats. Identities = 68/291 (23%), Positives = 121/291 (41%), Gaps = 35/291 (12%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKAD-----TGKM-YAMKCLDKKRIKMKQGETLALNERIM 242 ++ ++G G FGEVY D +G++ A+K L K ++ E L Sbjct: 33 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLK-----E 87 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFS-------EADMR 295 L+S + P I+ + IL+LM GGDL +L + + + D+ Sbjct: 88 AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLV 147 Query: 296 FYAAEIILGLEHMHNRFVVYRDLKPANILL-----DEHGHVRISDLGLACDFSKKKPHAS 350 +I G ++ ++RDL N L+ V+I D GLA D K + Sbjct: 148 DLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK 207 Query: 351 VG----THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRM 405 G +MAPE L G+ + + +D +S G +++++L GH P+ H D + Sbjct: 208 RGEGLLPVRWMAPESLMDGI-FTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQT 266 Query: 406 TLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 +E P + +L +L+ ++ ++R Q+ + FR+ Sbjct: 267 --GGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHR--IQDQLQ--LFRNF 311 >6DBM-A nrPDB Length = 318 Score = 215 bits (547), Expect = 7e-56, Method: Composition-based stats. Identities = 63/270 (23%), Positives = 112/270 (41%), Gaps = 31/270 (11%) Query: 191 FSVHRIIGRGGFGEV----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 R +G G FG+V Y TG+M A+K L K G + + ++ Sbjct: 33 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-----KADAGPQHRSGWKQEIDIL 87 Query: 247 STGDCPFIVCMSYAFHTPD--KLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 T I+ L +++ + G L +L +H A + +A +I G Sbjct: 88 RTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRH-SIGLAQLLLFAQQICEG 146 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAP 359 + ++H++ ++RDL N+LLD V+I D GLA + + V G + AP Sbjct: 147 MAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAP 206 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRG-----HSP--FRQHKTKDKHEIDRMTLTMAVE 412 E L++ Y ++D +S G L++LL P F + + ++ + LT +E Sbjct: 207 ECLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLE 265 Query: 413 ------LPDSFSPELRSLLEGLLQRDVNRR 436 PD E+ L++ + + + R Sbjct: 266 RGERLPRPDKCPAEVYHLMKNCWETEASFR 295 >5AWM-A nrPDB Length = 394 Score = 214 bits (546), Expect = 7e-56, Method: Composition-based stats. Identities = 67/328 (20%), Positives = 117/328 (35%), Gaps = 62/328 (18%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + R IG G G V T + A+K L + Q T A L+ Sbjct: 44 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSR----PFQNVTHAKRAYREFKLMKL 99 Query: 249 GDCPFIVCMSYAF------HTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 + I+ + AF + +++LM+ +L + M + +++ Sbjct: 100 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD--LDHDRMSYLLYQML 156 Query: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK-KPHASVGTHGYMAPEV 361 G++H+H+ +++RDLKP+NI++ ++I D GLA V T Y APEV Sbjct: 157 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEV 216 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE--------- 412 + G+ Y + D +S+GC++ +++RG F D+ L Sbjct: 217 IL-GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 275 Query: 413 -------------------LPDSFSP------------ELRSLLEGLLQRDVNRRLGCLG 441 PD P + R+LL +L D +R+ Sbjct: 276 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI---- 331 Query: 442 RGAQEVKESPFFRSLDWQMVFLQKYPPP 469 E + + W P P Sbjct: 332 -SVDEALKHEYIN--VWYDAEEVDAPAP 356 >3M42-A nrPDB Length = 299 Score = 214 bits (546), Expect = 7e-56, Method: Composition-based stats. Identities = 57/291 (19%), Positives = 114/291 (39%), Gaps = 51/291 (17%) Query: 178 KNVELNIHLTMNDFSV-HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA 236 +++ + ++D+ V +++G G G+V T + +A+K L ++ E Sbjct: 6 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHW 65 Query: 237 LNERIMLSLVSTGDCPFIVCMSYAFHT----PDKLSFILDLMNGGDLHYHLSQHG--VFS 290 CP IV + + L +++ ++GG+L + G F+ Sbjct: 66 ----------RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 115 Query: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDE---HGHVRISDLGLACDFSKKKP 347 E + I ++++H+ + +RD+KP N+L + ++++D G A + + Sbjct: 116 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT---- 171 Query: 348 HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR-QHKTKDKHEIDRMT 406 G YD S D +SLG +++ LL G+ PF H + Sbjct: 172 -----------------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI 214 Query: 407 LTMAVELP----DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 E P S E++ L+ LL+ + +R+ E P+ Sbjct: 215 RMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT-----EFMNHPWI 260 >4EQM-A nrPDB Length = 294 Score = 214 bits (546), Expect = 9e-56, Method: Composition-based stats. Identities = 58/264 (21%), Positives = 108/264 (40%), Gaps = 9/264 (3%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + +G GG VY A+K + I ++ E + S Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAI---FIPPREKEETLKRFEREVHNSSQ 67 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 IV M D +++ + G L ++ HG S + +I+ G++H Sbjct: 68 LSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHA 127 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK---KKPHASVGTHGYMAPEVLQKG 365 H+ +V+RD+KP NIL+D + ++I D G+A S+ + + +GT Y +PE KG Sbjct: 128 HDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPE-QAKG 186 Query: 366 VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD--KHEIDRMTLTMAVELPDSFSPELRS 423 A D D +S+G +L+++L G PF I + ++ L + Sbjct: 187 EATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQSLSN 246 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEV 447 ++ ++D R + ++ Sbjct: 247 VILRATEKDKANRYKTIQEMKDDL 270 >2W96-B nrPDB Length = 306 Score = 214 bits (545), Expect = 1e-55, Method: Composition-based stats. Identities = 64/299 (21%), Positives = 119/299 (39%), Gaps = 40/299 (13%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 + + + IG G +G VY R +G A+K + + + E +L Sbjct: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPN-GEEGLPISTVREVALLRR 59 Query: 246 VSTGDCPFIVCMSYAFHTPD-----KLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYA 298 + + P +V + T K++ + + ++ DL +L + ++ Sbjct: 60 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLM 118 Query: 299 AEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYM 357 + + GL+ +H +V+RDLKP NIL+ G V+++D GLA +S + V T Y Sbjct: 119 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYR 178 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK--HEIDRMTLTMAVELPD 415 APEVL + Y + D +S+GC+ ++ R F + D+ D + L + P Sbjct: 179 APEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 237 Query: 416 SFS------------------PELRS----LLEGLLQRDVNRRLGCLGRGAQEVKESPF 452 S PE+ LL +L + ++R+ + + Sbjct: 238 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR-----ALQHSY 291 >1FVR-A nrPDB Length = 327 Score = 213 bits (543), Expect = 2e-55, Method: Composition-based stats. Identities = 60/272 (22%), Positives = 111/272 (40%), Gaps = 29/272 (10%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY--AMKCLDKKRIKMKQGETLALNERIML 243 L ND +IG G FG+V R G A+K + + K + E Sbjct: 22 LDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEV--- 78 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVF-------------- 289 L G P I+ + A L ++ G+L L + V Sbjct: 79 -LCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTAS 137 Query: 290 --SEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC--DFSKK 345 S + +AA++ G++++ + ++RDL NIL+ E+ +I+D GL+ + K Sbjct: 138 TLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVK 197 Query: 346 KPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDR 404 K + +MA E L V Y +++D +S G +L++++ G +P+ + +E + Sbjct: 198 KTMGRLPVR-WMAIESLNYSV-YTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYE--K 253 Query: 405 MTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + +E P + E+ L+ + R Sbjct: 254 LPQGYRLEKPLNCDDEVYDLMRQCWREKPYER 285 >1S9I-A nrPDB Length = 354 Score = 213 bits (543), Expect = 2e-55, Method: Composition-based stats. Identities = 64/316 (20%), Positives = 122/316 (38%), Gaps = 57/316 (18%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 L +DF +G G G V + +G + A K + ++ + L Sbjct: 12 ELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLI-----HLEIKPAIRNQIIRELQ 66 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 ++ + P+IV AF++ ++S ++ M+GG L L + E + + ++ G Sbjct: 67 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG 126 Query: 305 LEHM-HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 363 L ++ +++RD+KP+NIL++ G +++ D G++ ++ VGT YMAPE LQ Sbjct: 127 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ 186 Query: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI--------------------- 402 G Y +D +S+G L +L G P K+ I Sbjct: 187 -GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPR 245 Query: 403 -----------------------DRMTLTMAVELPDS-FSPELRSLLEGLLQRDVNRRLG 438 D + +LP+ F+P+ + + L ++ R Sbjct: 246 PPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAER-- 303 Query: 439 CLGRGAQEVKESPFFR 454 + + F + Sbjct: 304 ---ADLKMLTNHTFIK 316 >6F3F-A nrPDB Length = 455 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 52/260 (20%), Positives = 101/260 (38%), Gaps = 18/260 (6%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 + + +G+G FGEV+ T + A+K L + + Sbjct: 181 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAF-------LQE 232 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH--GVFSEADMRFYAAE 300 ++ +V + YA + + + + + MN G L L + +A+ Sbjct: 233 AQVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQ 291 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG---THGYM 357 I G+ ++ V+RDL+ ANIL+ E+ +++D GLA + A G + Sbjct: 292 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 351 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 APE G + +D +S G +L +L G P+ ++ +D++ + P Sbjct: 352 APEAALYGR-FTIKSDVWSFGILLTELTTKGRVPYPGMVNREV--LDQVERGYRMPCPPE 408 Query: 417 FSPELRSLLEGLLQRDVNRR 436 L L+ +++ R Sbjct: 409 CPESLHDLMCQCWRKEPEER 428 >3SXS-A nrPDB Length = 268 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 46/260 (17%), Positives = 105/260 (40%), Gaps = 18/260 (6%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKM-YAMKCLDKKRIKMKQGETLALNERI 241 ++ L + ++ + +G G FG V + G+ A+K + + + + + Sbjct: 2 HMELKREEITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSEDE---FFQEAQT 56 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAE 300 M+ L P +V + + + ++ G L +L HG + + + Sbjct: 57 MMKL----SHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYD 112 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GYM 357 + G+ + + ++RDL N L+D V++SD G+ + +SVGT + Sbjct: 113 VCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWS 172 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 APEV Y S +D ++ G +++++ G P+ + + + +++ + P Sbjct: 173 APEVFHY-FKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEV--VLKVSQGHRLYRPHL 229 Query: 417 FSPELRSLLEGLLQRDVNRR 436 S + ++ +R Sbjct: 230 ASDTIYQIMYSCWHELPEKR 249 >5GRN-A nrPDB Length = 356 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 60/289 (20%), Positives = 115/289 (39%), Gaps = 42/289 (14%) Query: 184 IHLTMNDFSVHRIIGRGGFGEV-----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALN 238 + + R++G G FG+V YG ++ A+K L K + + + L Sbjct: 41 WEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKML-KPTARSSEKQALMSE 99 Query: 239 ERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG----------- 287 +IM L G IV + A + I + GDL +L ++ Sbjct: 100 LKIMTHL---GPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSM 156 Query: 288 ---------------VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVR 332 + D+ + ++ G+E + ++ V+RDL N+LL + V+ Sbjct: 157 LDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVK 216 Query: 333 ISDLGLACDFSKKKPHASVGT----HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-G 387 I D GLA D + S G+ +MAPE + + Y + +D +S G +L+++ G Sbjct: 217 ICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNL-YTTLSDVWSYGILLWEIFSLG 275 Query: 388 HSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 +P+ D +++ + PD + E+ ++ + +R Sbjct: 276 GTPYPGM-MVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKR 323 >3TT0-A nrPDB Length = 382 Score = 213 bits (542), Expect = 3e-55, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 110/281 (39%), Gaps = 35/281 (12%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCR-------KADTGKMYAMKCLDKKRIKMKQGETLA 236 L + + + +G G FG+V K + A+K L K K L Sbjct: 64 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLSDLI 122 Query: 237 LNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-------- 288 +M + G I+ + A L I++ + G+L +L Sbjct: 123 SEMEMMKMI---GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYN 179 Query: 289 --------FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC 340 S D+ A ++ G+E++ ++ ++RDL N+L+ E ++I+D GLA Sbjct: 180 PSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR 239 Query: 341 DFSKKKPHASVGT----HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHK 395 D + +MAPE L + Y +D +S G +L+++ G SP+ Sbjct: 240 DIHHIDYYKKTTNGRLPVKWMAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPGVP 298 Query: 396 TKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 ++ ++ + ++ P + + EL ++ ++R Sbjct: 299 VEELFKL--LKEGHRMDKPSNCTNELYMMMRDCWHAVPSQR 337 >2OGV-A nrPDB Length = 317 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 55/274 (20%), Positives = 100/274 (36%), Gaps = 26/274 (9%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKM-----YAMKCLDKKRIKMKQGETLAL 237 N+ + +G G FG+V GK A+K L K + E L Sbjct: 32 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADEKEALMS 90 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH----------G 287 +IM L G IV + A + I + GDL L + Sbjct: 91 ELKIMSHL---GQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGR 147 Query: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 347 D+ +++++ G+ + ++ ++RD+ N+LL +I D GLA D Sbjct: 148 PLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSN 207 Query: 348 HASVGTHG----YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEI 402 + G +MAPE + V Y +D +S G +L+++ G +P+ + Sbjct: 208 YIVKGNARLPVKWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPGI-LVNSKFY 265 Query: 403 DRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + + P + S+++ + R Sbjct: 266 KLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR 299 >4QTB-A nrPDB Length = 380 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 112/304 (36%), Gaps = 52/304 (17%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 ++ + IG G +G V A+K + + +T + ++ Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-----PFEHQTYCQRTLREIQILLRF 96 Query: 250 DCPFIVCMSYAF-----HTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 ++ + + + DLM DL+ L S + ++ +I+ G Sbjct: 97 RHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRG 154 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA-----SVGTHGYMAP 359 L+++H+ V++RDLKP+N+L++ ++I D GLA + H V T Y AP Sbjct: 155 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 214 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE------- 412 E++ Y S D +S+GC+L ++L F D+ L + Sbjct: 215 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 274 Query: 413 ----------------------LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKES 450 P S S L LL+ +L + N+R+ +E Sbjct: 275 NMKARNYLQSLPSKTKVAWAKLFPKSDSKAL-DLLDRMLTFNPNKRI-----TVEEALAH 328 Query: 451 PFFR 454 P+ Sbjct: 329 PYLE 332 >4OLI-A nrPDB Length = 645 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 62/270 (22%), Positives = 112/270 (41%), Gaps = 31/270 (11%) Query: 191 FSVHRIIGRGGFGEV----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 R +G G FG+V Y TG+M A+K L K G + + ++ Sbjct: 355 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-----KADCGPQHRSGWKQEIDIL 409 Query: 247 STGDCPFIVCMSYAFHT--PDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 T I+ L +++ + G L +L +H A + +A +I G Sbjct: 410 RTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH-SIGLAQLLLFAQQICEG 468 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAP 359 + ++H++ ++R+L N+LLD V+I D GLA + + V G + AP Sbjct: 469 MAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAP 528 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRG-----HSP--FRQHKTKDKHEIDRMTLTMAVE 412 E L++ Y ++D +S G L++LL P F + + ++ + LT +E Sbjct: 529 ECLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLE 587 Query: 413 ------LPDSFSPELRSLLEGLLQRDVNRR 436 PD E+ L++ + + + R Sbjct: 588 RGERLPRPDKCPCEVYHLMKNCWETEASFR 617 Score = 115 bits (287), Expect = 8e-26, Method: Composition-based stats. Identities = 44/255 (17%), Positives = 87/255 (34%), Gaps = 24/255 (9%) Query: 208 CRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKL 267 R +K LD +AL SL+S + + + Sbjct: 88 GRDRGQELRVVLKVLDPS------HHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPEN 141 Query: 268 SFILDLMNGGDLHYHLSQ-HGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL- 325 + + + G L L + G A A ++ L ++ N+ +V+ ++ NILL Sbjct: 142 IMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLA 201 Query: 326 ------DEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVA-YDSSADWFSLG 378 +++SD G+ ++ ++APE L G ++ D + G Sbjct: 202 RLGLAEGTSPFIKLSDPGVGLGALSREERVER--IPWLAPECLPGGANSLSTAMDKWGFG 259 Query: 379 CMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRL 437 L ++ G +P + +K + LP+ P+L +L L + +R Sbjct: 260 ATLLEICFDGEAPLQSRSPSEKEHFYQRQH----RLPEPSCPQLATLTSQCLTYEPTQRP 315 Query: 438 GCLG--RGAQEVKES 450 R ++ Sbjct: 316 SFRTILRDLTRLQPH 330 >3PG1-A nrPDB Length = 362 Score = 212 bits (540), Expect = 4e-55, Method: Composition-based stats. Identities = 70/315 (22%), Positives = 128/315 (40%), Gaps = 48/315 (15%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-----DKKRIKMKQGETLAL 237 +H + ++V R I G +G V ++ G A+K + D + + + L Sbjct: 16 ELHAMQSPYTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCK 74 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPD-----KLSFILDLMNGGDLHYHLS-QHGVFSE 291 + L++ P I+ + F + KL + +LM DL + Q V S Sbjct: 75 RVLREIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRT-DLAQVIHDQRIVISP 133 Query: 292 ADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV 351 ++++ I+LGL +H VV+RDL P NILL ++ + I D LA + + Sbjct: 134 QHIQYFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHY 193 Query: 352 GT-HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTM 409 T Y APE++ + + D +S GC++ ++ + FR ++ ++I + T Sbjct: 194 VTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTP 253 Query: 410 AVE-------------LPDSFS---------------PELRSLLEGLLQRDVNRRLGCLG 441 +E L +S S P L+ +L+ + RR+ Sbjct: 254 KIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRI---- 309 Query: 442 RGAQEVKESPFFRSL 456 ++ P+F SL Sbjct: 310 -STEQALRHPYFESL 323 >3E7O-A nrPDB Length = 360 Score = 212 bits (540), Expect = 4e-55, Method: Composition-based stats. Identities = 71/328 (21%), Positives = 127/328 (38%), Gaps = 61/328 (18%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + + + IG G G V G A+K L + Q +T A L L+ Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSR----PFQNQTHAKRAYRELVLLK 76 Query: 248 TGDCPFIVCMSYAF------HTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 + I+ + F + +++LM+ +L + H M + ++ Sbjct: 77 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVI--HMELDHERMSYLLYQM 133 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK-KPHASVGTHGYMAPE 360 + G++H+H+ +++RDLKP+NI++ ++I D GLA S V T Y APE Sbjct: 134 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPE 193 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVE------- 412 V+ G+ Y + D +S+GC++ +L++G F+ D+ +++ T + E Sbjct: 194 VIL-GMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQP 252 Query: 413 --------------------LPDSFSP-----------ELRSLLEGLLQRDVNRRLGCLG 441 PD P + R LL +L D ++R+ Sbjct: 253 TVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRI---- 308 Query: 442 RGAQEVKESPFFRSLDWQMVFLQKYPPP 469 E P+ W + PPP Sbjct: 309 -SVDEALRHPYIT--VWYDPAEAEAPPP 333 >3DLS-A nrPDB Length = 335 Score = 212 bits (539), Expect = 5e-55, Method: Composition-based stats. Identities = 60/283 (21%), Positives = 117/283 (41%), Gaps = 24/283 (8%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMK--QGETLALNERIMLSLVST 248 +S +G G FG V+ + K +K + K+++ + + ++++S Sbjct: 26 YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSR 85 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGG-DLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 + I+ + F +++ G DL + +H E + +++ + + Sbjct: 86 VEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGY 145 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-HASVGTHGYMAPEVLQKGV 366 + + +++RD+K NI++ E +++ D G A + K + GT Y APEVL Sbjct: 146 LRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNP 205 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLE 426 + +SLG L+ L+ +PF + + T+ A+ P S EL SL+ Sbjct: 206 YRGPELEMWSLGVTLYTLVFEENPFCELEE---------TVEAAIHPPYLVSKELMSLVS 256 Query: 427 GLLQRDVNRRLGCLGRGAQEVKESPFFR------SLDWQMVFL 463 GLLQ RR +++ P+ W+ VF Sbjct: 257 GLLQPVPERR-----TTLEKLVTDPWVTQPVNLADYTWEEVFR 294 >2XS0-A nrPDB Length = 386 Score = 212 bits (539), Expect = 6e-55, Method: Composition-based stats. Identities = 68/334 (20%), Positives = 125/334 (37%), Gaps = 61/334 (18%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + + + IG G G V A + A+K L + Q +T A L L+ Sbjct: 25 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSR----PFQNQTHAKRAYRELVLMK 80 Query: 248 TGDCPFIVCMSYAF------HTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 + I+ + F + +++LM+ +L + M + ++ Sbjct: 81 CVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMD-ANLCQVIQME--LDHERMSYLLYQM 137 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA-SVGTHGYMAPE 360 + G++H+H+ +++RDLKP+NI++ ++I D GLA V T Y APE Sbjct: 138 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPE 197 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSFSP 419 V+ G+ Y + D +S+GC++ ++++G F D+ +++ T E P Sbjct: 198 VIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQP 256 Query: 420 E--------------------------------------LRSLLEGLLQRDVNRRLGCLG 441 R LL +L D ++R+ Sbjct: 257 TVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRI---- 312 Query: 442 RGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRG 475 E + P+ W + PPP IP + Sbjct: 313 -SVDEALQHPYIN--VWYDPSEAEAPPPKIPDKQ 343 >5B2L-A nrPDB Length = 324 Score = 211 bits (538), Expect = 6e-55, Method: Composition-based stats. Identities = 73/307 (23%), Positives = 126/307 (41%), Gaps = 18/307 (5%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 +ND +G G G+V+ R TG + A+K + + K + L + + Sbjct: 13 QAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVV--- 69 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 + + DCP+IV F T + ++LM G E + I+ Sbjct: 70 -LKSHDCPYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKA 128 Query: 305 LEHM-HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA-SVGTHGYMAPEVL 362 L ++ V++RD+KP+NILLDE G +++ D G++ K S G YMAPE + Sbjct: 129 LYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERI 188 Query: 363 Q----KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS-- 416 YD AD +SLG L +L G P++ KT D + ++ LP Sbjct: 189 DPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKT-DFEVLTKVLQEEPPLLPGHMG 247 Query: 417 FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGE 476 FS + +S ++ L +D +R ++ E F + + V + + ++ Sbjct: 248 FSGDFQSFVKDCLTKDHRKR-----PKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTES 302 Query: 477 VNAADAF 483 + Sbjct: 303 PRTSGVL 309 >3MIA-A nrPDB Length = 351 Score = 211 bits (538), Expect = 7e-55, Method: Composition-based stats. Identities = 60/327 (18%), Positives = 122/327 (37%), Gaps = 58/327 (17%) Query: 175 CQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGET 234 Q+ +VE ++ + IG+G FGEV+ R TG+ A+K + + + E Sbjct: 3 KQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKV----LMENEKEG 58 Query: 235 LALNERIMLSLVSTGDCPFIVCMSYAFHTP--------DKLSFILDLMNG---GDLHYHL 283 + + ++ +V + T + + D G L L Sbjct: 59 FPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL 118 Query: 284 SQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS 343 + F+ ++++ ++ GL ++H +++RD+K AN+L+ G ++++D GLA FS Sbjct: 119 VK---FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFS 175 Query: 344 ------KKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK 397 + V T Y PE+L Y D + GC++ ++ + + + Sbjct: 176 LAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 Query: 398 -DKHEIDRMTLTMAVELPDSF----------------------------SPELRSLLEGL 428 I ++ ++ E+ + P L++ L Sbjct: 236 HQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKL 295 Query: 429 LQRDVNRRLGCLGRGAQEVKESPFFRS 455 L D +R+ + + FF S Sbjct: 296 LVLDPAQRI-----DSDDALNHDFFWS 317 >3BEA-A nrPDB Length = 333 Score = 211 bits (537), Expect = 8e-55, Method: Composition-based stats. Identities = 56/278 (20%), Positives = 101/278 (36%), Gaps = 30/278 (10%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKM-----YAMKCLDKKRIKMKQGETLAL 237 N+ + +G G FG+V GK A+K L K + E L Sbjct: 40 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADEKEALMS 98 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--------- 288 +IM L G IV + A + I + GDL L + Sbjct: 99 ELKIMSHL---GQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFA 155 Query: 289 -----FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS 343 S D+ +++++ G+ + ++ ++RD+ N+LL +I D GLA D Sbjct: 156 IANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIM 215 Query: 344 KKKPHASVGTHG----YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 + G +MAPE + V Y +D +S G +L+++ G +P+ + Sbjct: 216 NDSNYIVKGNARLPVKWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPGI-LVN 273 Query: 399 KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + + P + S+++ + R Sbjct: 274 SKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR 311 >5VO2-A nrPDB Length = 300 Score = 211 bits (537), Expect = 1e-54, Method: Composition-based stats. Identities = 52/268 (19%), Positives = 102/268 (38%), Gaps = 23/268 (8%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + + + +G G G V+ R G+ A+K + L E + Sbjct: 7 WEVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRD------------LKETDIK 52 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 L P I+ +++ G L+ L + + + ++ I Sbjct: 53 HLRK-LKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAG 111 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH-ASVGTHGYMAPEVL 362 G+ ++H +++RDLK N+L+ V+ISD G + + S K + GT +MAPEV+ Sbjct: 112 GMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVI 171 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 + D +S G +L++LL G P++ + + ++ + +P S + Sbjct: 172 -RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAI-IWGVGSNSLHLPVPSSCPDGFK 229 Query: 423 SLLEGLLQRDVNRRLGCLGRGAQEVKES 450 LL R +++ Sbjct: 230 ILLRQCWNSKPRNR-----PSFRQILLH 252 >4E20-A nrPDB Length = 290 Score = 211 bits (537), Expect = 1e-54, Method: Composition-based stats. Identities = 63/270 (23%), Positives = 110/270 (40%), Gaps = 31/270 (11%) Query: 191 FSVHRIIGRGGFGEV----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 R +G G FG+V Y TG+M A+K L + G L + + ++ Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEG-----CGPQLRSGWQREIEIL 64 Query: 247 STGDCPFIVCMSYAFHT--PDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 T IV + +++ + G L +L +H V A + +A +I G Sbjct: 65 RTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCV-GLAQLLLFAQQICEG 123 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAP 359 + ++H + ++R L N+LLD V+I D GLA + + V G + AP Sbjct: 124 MAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAP 183 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLR----GHSPFRQHKTKDKHEIDRMTL-------- 407 E L++ Y ++D +S G L++LL SP + H +MT+ Sbjct: 184 ECLKECKFY-YASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTELLE 242 Query: 408 -TMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + PD E+ L++ + + + R Sbjct: 243 RGERLPRPDRCPCEIYHLMKNCWETEASFR 272 >4XCU-A nrPDB Length = 300 Score = 211 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 103/272 (37%), Gaps = 26/272 (9%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCR-------KADTGKMYAMKCLDKKRIKMKQGETLA 236 + + + +G G FG+V + D A+K L K K L Sbjct: 12 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKML-KDNASDKDLADLV 70 Query: 237 LNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-------GVF 289 +M + G I+ + L I++ G+L L G Sbjct: 71 SEMEVMKLI---GRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPL 127 Query: 290 SEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA 349 S + A ++ G++++ +R ++RDL N+L+ E ++I+D GLA + Sbjct: 128 SFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYK 187 Query: 350 SVGT----HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDR 404 +MAPE L V Y +D +S G +L+++ G SP+ ++ + R Sbjct: 188 KTSNGRLPVKWMAPEALFDRV-YTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLR 246 Query: 405 MTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 ++ P PEL L+ ++R Sbjct: 247 --EGHRMDRPPHCPPELYGLMRECWHAAPSQR 276 >5A46-A nrPDB Length = 386 Score = 211 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 65/355 (18%), Positives = 126/355 (35%), Gaps = 39/355 (10%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCR-------KADTGKMYAMKCLDKKRIKMKQGETLA 236 L + + + +G G FG+V K + A+K L K K L Sbjct: 35 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLSDLI 93 Query: 237 LNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-------- 288 +M + G I+ + A L I++ + G+L +L Sbjct: 94 SEMEMMKMI---GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYN 150 Query: 289 --------FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC 340 S D+ A ++ G+E++ ++ ++RDL N+L+ E ++I+D GLA Sbjct: 151 PSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR 210 Query: 341 DFSKKKPHASVGT----HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHK 395 D + +MAPE L + Y +D +S G +L+++ G SP+ Sbjct: 211 DIHHIDYYKKTTNGRLPVKWMAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPGVP 269 Query: 396 TKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 ++ ++ + ++ P + + EL ++ ++R + + Sbjct: 270 VEELFKL--LKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSN 327 Query: 456 LDWQMVF--LQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRN 508 ++ + L +Y P P + D F E L N Sbjct: 328 QEYLDLSMPLDQYSPSF-PDTRSSTCSSGED-SVFSHEPLPEEPCLPRHPAQLAN 380 >1LUF-A nrPDB Length = 343 Score = 211 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 57/282 (20%), Positives = 108/282 (38%), Gaps = 42/282 (14%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKA-----DTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 N+ R IG G FG V+ R + M A+K L ++ Q + + Sbjct: 47 NNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADF-----QREA 101 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ------------------ 285 +L++ D P IV + + + + M GDL+ L Sbjct: 102 ALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRA 161 Query: 286 ------HGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA 339 S A+ A ++ G+ ++ R V+RDL N L+ E+ V+I+D GL+ Sbjct: 162 RVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLS 221 Query: 340 CDFSKKKPHASVGT----HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQH 394 + + + G +M PE + Y + +D ++ G +L+++ G P+ Sbjct: 222 RNIYSADYYKADGNDAIPIRWMPPESIFYNR-YTTESDVWAYGVVLWEIFSYGLQPYYGM 280 Query: 395 KTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 ++ I + + P++ EL +L+ + R Sbjct: 281 AHEEV--IYYVRDGNILACPENCPLELYNLMRLCWSKLPADR 320 >5AMN-A nrPDB Length = 299 Score = 211 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 51/274 (18%), Positives = 112/274 (40%), Gaps = 28/274 (10%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGC-----RKADTGKMYAMKCLDKKRIKMKQGETLAL 237 + + + +G G FG+V + A+K L + + Sbjct: 17 KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSE-----LR 71 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ----------HG 287 + +++ + P ++ + A L I++ G L L + Sbjct: 72 DLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDER 131 Query: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 347 + D+ +A +I G++++ +V+RDL NIL+ E ++ISD GL+ D ++ Sbjct: 132 ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDS 191 Query: 348 HASVG----THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEI 402 + +MA E L + Y + +D +S G +L++++ G +P+ + Sbjct: 192 YVKRSQGRIPVKWMAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE--RLF 248 Query: 403 DRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + + +E PD+ S E+ L+ +++ ++R Sbjct: 249 NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKR 282 >3GQL-A nrPDB Length = 326 Score = 211 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 110/281 (39%), Gaps = 35/281 (12%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCR-------KADTGKMYAMKCLDKKRIKMKQGETLA 236 L + + + +G G FG+V K + A+K L K K L Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLSDLI 81 Query: 237 LNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-------- 288 +M + G I+ + A L I++ + G+L +L Sbjct: 82 SEMEMMKMI---GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYN 138 Query: 289 --------FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC 340 S D+ A ++ G+E++ ++ ++RDL N+L+ E ++I+D GLA Sbjct: 139 PSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR 198 Query: 341 DFSKKKPHASVGT----HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHK 395 D + +MAPE L + Y +D +S G +L+++ G SP+ Sbjct: 199 DIHHIDYYKKTTNGRLPVKWMAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPGVP 257 Query: 396 TKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 ++ ++ + ++ P + + EL ++ ++R Sbjct: 258 VEELFKL--LKEGHRMDKPSNCTNELYMMMRDCWHAVPSQR 296 >3A4O-X nrPDB Length = 286 Score = 211 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 52/265 (19%), Positives = 109/265 (41%), Gaps = 17/265 (6%) Query: 178 KNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLAL 237 + + + + +G G FGEV+ ++ K A+K L + ++ L Sbjct: 2 PWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMSVQA----FL 56 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS--QHGVFSEADMR 295 E +L+ T +V + + + I + M G L L + G + Sbjct: 57 EE---ANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLI 113 Query: 296 FYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG--- 352 ++A+I G+ ++ + ++RDL+ AN+L+ E +I+D GLA + A G Sbjct: 114 DFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKF 173 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAV 411 + APE + G + +D +S G +L++++ G P+ D + ++ + Sbjct: 174 PIKWTAPEAINFGC-FTIKSDVWSFGILLYEIVTYGKIPYPGRTNADV--MTALSQGYRM 230 Query: 412 ELPDSFSPELRSLLEGLLQRDVNRR 436 ++ EL +++ + R Sbjct: 231 PRVENCPDELYDIMKMCWKEKAEER 255 >4HZS-A nrPDB Length = 341 Score = 211 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 55/258 (21%), Positives = 108/258 (41%), Gaps = 18/258 (6%) Query: 190 DFSVHRIIGRGGFGEVYGC-RKADTGKMY--AMKCLDKKRIKMKQGETLALNERIMLSLV 246 D + +G G FG V A +GK A+KCL + + + E ++ + Sbjct: 13 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIRE---VNAM 69 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGL 305 + D ++ + TP + + +L G L L +H G F + YA ++ G+ Sbjct: 70 HSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 128 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPE 360 ++ ++ ++RDL N+LL V+I D GL + H + H + APE Sbjct: 129 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 188 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQ-HKTKDKHEIDRMTLTMAVELPDSFS 418 L K + ++D + G L+++ G P+ + ++ H+ID+ + P+ Sbjct: 189 SL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK--EGERLPRPEDCP 245 Query: 419 PELRSLLEGLLQRDVNRR 436 ++ +++ R Sbjct: 246 QDIYNVMVQCWAHKPEDR 263 >3KRL-A nrPDB Length = 335 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 56/280 (20%), Positives = 101/280 (36%), Gaps = 32/280 (11%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKM-----YAMKCLDKKRIKMKQGETLAL 237 N+ + +G G FG+V GK A+K L K + E L Sbjct: 40 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADEKEALMS 98 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--------- 288 +IM L G IV + A + I + GDL L + Sbjct: 99 ELKIMSHL---GQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNP 155 Query: 289 -------FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD 341 S D+ +++++ G+ + ++ ++RD+ N+LL +I D GLA D Sbjct: 156 SHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARD 215 Query: 342 FSKKKPHASVGTHG----YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKT 396 + G +MAPE + V Y +D +S G +L+++ G +P+ Sbjct: 216 IMNDSNYIVKGNARLPVKWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPGI-L 273 Query: 397 KDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + + + P + S+++ + R Sbjct: 274 VNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR 313 >1JNK-A nrPDB Length = 423 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 65/328 (19%), Positives = 121/328 (36%), Gaps = 61/328 (18%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + + + IG G G V A + A+K L + Q +T A L L+ Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR----PFQNQTHAKRAYRELVLMK 116 Query: 248 TGDCPFIVCMSYAF------HTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 + I+ + F + +++LM+ +L + M + ++ Sbjct: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME--LDHERMSYLLYQM 173 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC-DFSKKKPHASVGTHGYMAPE 360 + G++H+H+ +++RDLKP+NI++ ++I D GLA + V T Y APE Sbjct: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSFSP 419 V+ G+ Y + D +S+GC++ +++R F D+ +++ T E P Sbjct: 234 VIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 Query: 420 E--------------------------------------LRSLLEGLLQRDVNRRLGCLG 441 R LL +L D +R+ Sbjct: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI---- 348 Query: 442 RGAQEVKESPFFRSLDWQMVFLQKYPPP 469 + + P+ W + PPP Sbjct: 349 -SVDDALQHPYIN--VWYDPAEVEAPPP 373 >5HI2-A nrPDB Length = 283 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 59/277 (21%), Positives = 120/277 (43%), Gaps = 24/277 (8%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 + + +V + IG G FG VY + A+K L ++++ + E L + Sbjct: 14 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFKNEVGVLRKTRH 70 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADMRFYAAEI 301 ++++ + + T +L+ + G L++HL F + A + Sbjct: 71 VNIL----------LFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQT 120 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA----CDFSKKKPHASVGTHGYM 357 G++++H + +++RDLK NI L E V+I D GLA + G+ +M Sbjct: 121 ARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM 180 Query: 358 APEVL--QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP- 414 APEV+ Q Y +D ++ G +L++L+ G P+ +D+ +++ +L Sbjct: 181 APEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSK 240 Query: 415 --DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKE 449 + ++ L+ L++ + R R E++E Sbjct: 241 VRSNCPKRMKRLMAECLKKKRDERPS-FPRILAEIEE 276 >2DQ7-X nrPDB Length = 283 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 53/259 (20%), Positives = 102/259 (39%), Gaps = 18/259 (6%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 + + + +G G FGEV+ A+K L + + L E ++ Sbjct: 4 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPES----FLEEAQIM 58 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS--QHGVFSEADMRFYAAEI 301 + +V + YA + + + + + MN G L L + ++ AA++ Sbjct: 59 KKLKHDK---LVQL-YAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQV 114 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG---THGYMA 358 G+ ++ ++RDL+ ANIL+ +I+D GLA + A G + A Sbjct: 115 AAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTA 174 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSF 417 PE G + +D +S G +L +L+ G P+ ++ E ++ + P Sbjct: 175 PEAALYGR-FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLE--QVERGYRMPCPQDC 231 Query: 418 SPELRSLLEGLLQRDVNRR 436 L L+ ++D R Sbjct: 232 PISLHELMIHCWKKDPEER 250 >5O2C-A nrPDB Length = 380 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 82/369 (22%), Positives = 155/369 (42%), Gaps = 40/369 (10%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 +GRG F VY +T A L +++ + + ++ L P IV Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGL----QHPNIV 87 Query: 256 CMSYAFHT----PDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNR 311 ++ + + + +LM G L +L + V +R + +I+ GL+ +H R Sbjct: 88 RFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTR 147 Query: 312 --FVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAY 368 +++RDLK NI + G V+I DLGLA + +GT +MAPE+ ++ Y Sbjct: 148 TPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE--HY 205 Query: 369 DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS----PELRSL 424 D S D ++ G + ++ P+ + ++ +I R + P SF+ PE++ + Sbjct: 206 DESVDVYAFGMCMLEMATSEYPYSE--CQNAAQIYRKVTSGIK--PASFNKVTDPEVKEI 261 Query: 425 LEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFD 484 +EG ++++ + RL +++ FF V L + N++ A Sbjct: 262 IEGCIRQNKSERLSI-----RDLLNHAFFAEDTGLRVELAEEDDC-------SNSSLALR 309 Query: 485 IGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAET-VFDTINAET------DRLE 537 + D + KG + E N E E+ ++ F +++ DR+ Sbjct: 310 LWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVT 369 Query: 538 ARKKTKNKQ 546 KKT+ K+ Sbjct: 370 PIKKTREKK 378 >5O2B-A nrPDB Length = 285 Score = 209 bits (533), Expect = 3e-54, Method: Composition-based stats. Identities = 64/269 (23%), Positives = 122/269 (45%), Gaps = 26/269 (9%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 +GRG F VY +T A L +++ + + ++ L P IV Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGL----QHPNIV 78 Query: 256 CMSYAFHT----PDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNR 311 ++ + + + +LM G L +L + V +R + +I+ GL+ +H R Sbjct: 79 RFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTR 138 Query: 312 --FVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAY 368 +++RDLK NI + G V+I DLGLA + +GT +MAPE+ ++ Y Sbjct: 139 TPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE--HY 196 Query: 369 DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS----PELRSL 424 D S D ++ G + ++ P+ + ++ +I R + P SF+ PE++ + Sbjct: 197 DESVDVYAFGMCMLEMATSEYPYSE--CQNAAQIYRKVTSGIK--PASFNKVTDPEVKEI 252 Query: 425 LEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 +EG ++++ + RL +++ FF Sbjct: 253 IEGCIRQNKSERLSI-----RDLLNHAFF 276 >1U54-B nrPDB Length = 291 Score = 209 bits (533), Expect = 3e-54, Method: Composition-based stats. Identities = 55/258 (21%), Positives = 108/258 (41%), Gaps = 18/258 (6%) Query: 190 DFSVHRIIGRGGFGEVYGC-RKADTGKMY--AMKCLDKKRIKMKQGETLALNERIMLSLV 246 D + +G G FG V A +GK A+KCL + + + E ++ + Sbjct: 19 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIRE---VNAM 75 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGL 305 + D ++ + TP + + +L G L L +H G F + YA ++ G+ Sbjct: 76 HSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 134 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPE 360 ++ ++ ++RDL N+LL V+I D GL + H + H + APE Sbjct: 135 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 194 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQ-HKTKDKHEIDRMTLTMAVELPDSFS 418 L K + ++D + G L+++ G P+ + ++ H+ID+ + P+ Sbjct: 195 SL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK--EGERLPRPEDCP 251 Query: 419 PELRSLLEGLLQRDVNRR 436 ++ +++ R Sbjct: 252 QDIYNVMVQCWAHKPEDR 269 >3ORP-A nrPDB Length = 311 Score = 209 bits (533), Expect = 3e-54, Method: Composition-based stats. Identities = 57/273 (20%), Positives = 111/273 (40%), Gaps = 15/273 (5%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + + I+G GG EV+ R + A+K L R + + + L R + Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVL---RADLARDPSFYLRFRREAQNAAA 68 Query: 249 GDCPFIVCMSYAFHTPDK----LSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 + P IV + +++ ++G L + G + A+ Sbjct: 69 LNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQA 128 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-----VGTHGYMAP 359 L H +++RD+KPANI++ V++ D G+A + + +GT Y++P Sbjct: 129 LNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSP 188 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSFS 418 E +G + D+ +D +SLGC+L+++L G PF ++ R + S Sbjct: 189 E-QARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLS 247 Query: 419 PELRSLLEGLLQRDVNRRL-GCLGRGAQEVKES 450 +L +++ L ++ R A V+ Sbjct: 248 ADLDAVVLKALAKNPENRYQTAAEMRADLVRVH 280 >3E3P-A nrPDB Length = 360 Score = 209 bits (532), Expect = 3e-54, Method: Composition-based stats. Identities = 67/312 (21%), Positives = 126/312 (40%), Gaps = 55/312 (17%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 M+ F V R+ G+G FG V ++ TG A+K + Q E ++ ++ Sbjct: 22 MDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVI-------QDPRFRNRELQIMQDLA 74 Query: 248 TGDCPFIVCMSYAFHTPDK-------LSFILDLMN---GGDLHYHLSQHGVFSEADMRFY 297 P IV + F+T + L+ +++ + + + ++ + Sbjct: 75 VLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVF 134 Query: 298 AAEIILGLEHMH--NRFVVYRDLKPANILLDE-HGHVRISDLGLACDFSKKKPH-ASVGT 353 ++I + +H + V +RD+KP N+L++E G +++ D G A S +P+ A + + Sbjct: 135 LFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICS 194 Query: 354 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVE 412 Y APE++ Y ++ D +S+GC+ +++ G FR + + HEI R+ + E Sbjct: 195 RYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSRE 254 Query: 413 LPDSFSP----------------------------ELRSLLEGLLQRDVNRRLGCLGRGA 444 + +P E LL LLQ R+ Sbjct: 255 VLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPY---- 310 Query: 445 QEVKESPFFRSL 456 E P+F L Sbjct: 311 -EALCHPYFDEL 321 >3QGY-A nrPDB Length = 286 Score = 209 bits (532), Expect = 3e-54, Method: Composition-based stats. Identities = 50/261 (19%), Positives = 109/261 (41%), Gaps = 16/261 (6%) Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240 L++ + ++ + + IG G FG V+ + K A+K + + + E + E Sbjct: 19 SLHMVIDPSELTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMS----EDDFIEEA 73 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADMRFYAA 299 ++ +S P +V + + + + M G L +L Q G+F+ + Sbjct: 74 EVMMKLS---HPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCL 130 Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GY 356 ++ G+ ++ V++RDL N L+ E+ +++SD G+ + +S GT + Sbjct: 131 DVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKW 190 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPD 415 +PEV Y S +D +S G +++++ G P+ + E ++ + P Sbjct: 191 ASPEVFSFSR-YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVE--DISTGFRLYKPR 247 Query: 416 SFSPELRSLLEGLLQRDVNRR 436 S + ++ + R Sbjct: 248 LASTHVYQIMNHCWKERPEDR 268 >4R7H-A nrPDB Length = 343 Score = 209 bits (532), Expect = 4e-54, Method: Composition-based stats. Identities = 55/287 (19%), Positives = 100/287 (34%), Gaps = 39/287 (13%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKM-----YAMKCLDKKRIKMKQGETLAL 237 N+ + +G G FG+V GK A+K L K + E L Sbjct: 44 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML-KSTAHADEKEALMS 102 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH----------- 286 +IM L G IV + A + I + GDL L + Sbjct: 103 ELKIMSHL---GQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSP 159 Query: 287 ------------GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRIS 334 D+ +++++ G+ + ++ ++RD+ N+LL +I Sbjct: 160 GQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIG 219 Query: 335 DLGLACDFSKKKPHASVGTHG----YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHS 389 D GLA D + G +MAPE + V Y +D +S G +L+++ G + Sbjct: 220 DFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSV-YTVQSDVWSYGILLWEIFSLGLN 278 Query: 390 PFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 P+ + + + P + S+++ + R Sbjct: 279 PYPGI-LVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR 324 >5SYS-A nrPDB Length = 286 Score = 209 bits (532), Expect = 4e-54, Method: Composition-based stats. Identities = 52/260 (20%), Positives = 100/260 (38%), Gaps = 18/260 (6%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 + + +G+G FGE + T + A+K L + + Sbjct: 12 AWEIPRESLRLEVKLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMSPEAF-------LQE 63 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH--GVFSEADMRFYAAE 300 ++ +V + YA + + + + + M+ G L L + AA+ Sbjct: 64 AQVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQ 122 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG---THGYM 357 I G+ ++ V+RDL+ ANIL+ E+ +++D GLA + A G + Sbjct: 123 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 182 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 APE G + +D +S G +L +L G P+ ++ +D++ + P Sbjct: 183 APEAALYGR-FTIKSDVWSFGILLTELTTKGRVPYPGMVNREV--LDQVERGYRMPCPPE 239 Query: 417 FSPELRSLLEGLLQRDVNRR 436 L L+ ++D R Sbjct: 240 CPESLHDLMCQCWRKDPEER 259 >6FEX-A nrPDB Length = 321 Score = 209 bits (531), Expect = 5e-54, Method: Composition-based stats. Identities = 60/293 (20%), Positives = 107/293 (36%), Gaps = 46/293 (15%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGC----------------RKADTGKMYAMKCLDKKRI 227 + + +G G FGEV+ C + + A+K L Sbjct: 11 VDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDAT 70 Query: 228 KMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG 287 K + + L + ++S P I+ + D L I D M GDL+ LS H Sbjct: 71 KNARNDFLK-----EVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQ 125 Query: 288 -------------VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRIS 334 S + AA+I G+ ++ V+RDL N L+ E+ ++I+ Sbjct: 126 LEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 185 Query: 335 DLGLACDFSKKKPHASVG----THGYMAPEVLQKGVAYDSSADWFSLGCMLFK--LLRGH 388 D G++ + + G +MA E + G + +++D ++ G L++ +L Sbjct: 186 DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMG-KFTTASDVWAFGVTLWEVLMLCRA 244 Query: 389 SPFRQHK----TKDKHEIDRMTLTMAV-ELPDSFSPELRSLLEGLLQRDVNRR 436 PF Q ++ E R P + L L+ R+ +R Sbjct: 245 QPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQR 297 >4Y83-A nrPDB Length = 332 Score = 208 bits (530), Expect = 5e-54, Method: Composition-based stats. Identities = 70/291 (24%), Positives = 121/291 (41%), Gaps = 34/291 (11%) Query: 166 IESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK 225 I+SD WK NI +DF I RG FG+VY + T K A K + Sbjct: 60 IDSDVL--LIPWKLTYRNIG---SDF-----IPRGAFGKVYLAQDIKTKKRMACKLIPVD 109 Query: 226 RIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ 285 + K E + + I + A + + ++ GG + L Sbjct: 110 QFKPSDVE-----------IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLES 158 Query: 286 HGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK 345 G E ++ + ++ GL+ +H++ V++ D+KP+NI+ V + D GL+ ++ Sbjct: 159 CGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTED 217 Query: 346 K--PHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH--- 400 P GT YM+PEV+ + + AD +SLG L + G P+ + + + Sbjct: 218 VYFPKDLRGTEIYMSPEVIL-CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSY 276 Query: 401 -EIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKES 450 I ++ D SP +R L+E L+R+ N R A ++ + Sbjct: 277 LYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHR-----PRAADLLKH 322 >3IO7-A nrPDB Length = 313 Score = 208 bits (530), Expect = 6e-54, Method: Composition-based stats. Identities = 60/272 (22%), Positives = 113/272 (41%), Gaps = 33/272 (12%) Query: 191 FSVHRIIGRGGFGEVYGCR----KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 + +G+G FG V CR + +TG++ A+K L E + + ++ Sbjct: 30 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST------EEHLRDFEREIEIL 83 Query: 247 STGDCPFIVCMSYAFHTPDK--LSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIIL 303 + IV ++ + L I++ + G L +L +H + Y ++I Sbjct: 84 KSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICK 143 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMA 358 G+E++ + ++RDL NIL++ V+I D GL + K + V G + A Sbjct: 144 GMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYA 203 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLR-----GHSP--FRQHKTKDK-------HEIDR 404 PE L + + ++D +S G +L++L P F + DK H I+ Sbjct: 204 PESLTES-KFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIEL 262 Query: 405 MTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + + PD E+ ++ +VN+R Sbjct: 263 LKNNGRLPRPDGCPDEIYMIMTECWNNNVNQR 294 >6BSD-A nrPDB Length = 876 Score = 208 bits (530), Expect = 6e-54, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 107/299 (35%), Gaps = 52/299 (17%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGC----------------RKADTGKMYAMKCLDKKRI 227 + + +G G FGEV+ C + + A+K L Sbjct: 566 VDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDAT 625 Query: 228 KMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG 287 K + + L + ++S P I+ + D L I D M GDL+ LS H Sbjct: 626 KNARNDFLK-----EVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQ 680 Query: 288 -------------------VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEH 328 S + AA+I G+ ++ V+RDL N L+ E+ Sbjct: 681 LEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGEN 740 Query: 329 GHVRISDLGLACDFSKKKPHASVG----THGYMAPEVLQKGVAYDSSADWFSLGCMLFK- 383 ++I+D G++ + + G +MA E + G + +++D ++ G L++ Sbjct: 741 FTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMG-KFTTASDVWAFGVTLWEV 799 Query: 384 -LLRGHSPFRQHK----TKDKHEIDRMTLTMAV-ELPDSFSPELRSLLEGLLQRDVNRR 436 +L PF Q ++ E R P + L L+ R+ +R Sbjct: 800 LMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQR 858 >4E7W-A nrPDB Length = 394 Score = 207 bits (528), Expect = 9e-54, Method: Composition-based stats. Identities = 70/335 (20%), Positives = 137/335 (40%), Gaps = 60/335 (17%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 ++ ++IG G FG V+ + ++ ++ K L KR K ++ L ++ Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDEVAIKKVLQDKRFKNRE-----------LQIMRIVK 90 Query: 251 CPFIVCMSYAFHTPDK------LSFILDLMNGGDLHYHLSQH-----GVFSEADMRFYAA 299 P +V + F++ L+ +L+ + + Y S+H ++ Y Sbjct: 91 HPNVVDLKAFFYSNGDKKDEVFLNLVLEYVP--ETVYRASRHYAKLKQTMPMLLIKLYMY 148 Query: 300 EIILGLEHMHNRFVVYRDLKPANILLDE-HGHVRISDLGLACDFSKKKPHAS-VGTHGYM 357 +++ L ++H+ + +RD+KP N+LLD G +++ D G A +P+ S + + Y Sbjct: 149 QLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYR 208 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-------------HEIDR 404 APE++ Y ++ D +S GC++ +L++G F D+ +I Sbjct: 209 APELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKT 268 Query: 405 MTLT-MAVELP------------DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESP 451 M M + P P+ L+ LL+ + RL A E P Sbjct: 269 MNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARL-----TAIEALCHP 323 Query: 452 FFRSL---DWQMVFLQKYPPPLIPPRGEVNAADAF 483 FF L + +M ++ PP + E++ Sbjct: 324 FFDELRTGEARMPNGRELPPLFNWTKEELSVRPDL 358 >2W1I-A nrPDB Length = 326 Score = 207 bits (528), Expect = 1e-53, Method: Composition-based stats. Identities = 60/272 (22%), Positives = 113/272 (41%), Gaps = 33/272 (12%) Query: 191 FSVHRIIGRGGFGEVYGCR----KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 + +G+G FG V CR + +TG++ A+K L E + + ++ Sbjct: 43 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST------EEHLRDFEREIEIL 96 Query: 247 STGDCPFIVCMSYAFHTPDK--LSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIIL 303 + IV ++ + L I++ + G L +L +H + Y ++I Sbjct: 97 KSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICK 156 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMA 358 G+E++ + ++RDL NIL++ V+I D GL + K + V G + A Sbjct: 157 GMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYA 216 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLR-----GHSP--FRQHKTKDK-------HEIDR 404 PE L + + ++D +S G +L++L P F + DK H I+ Sbjct: 217 PESLTES-KFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIEL 275 Query: 405 MTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + + PD E+ ++ +VN+R Sbjct: 276 LKNNGRLPRPDGCPDEIYMIMTECWNNNVNQR 307 >6GVJ-A nrPDB Length = 429 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 58/278 (20%), Positives = 117/278 (42%), Gaps = 24/278 (8%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 +S+ + IG GG +V+ ++YA+K ++ + + ++ + L D Sbjct: 146 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 I+ + T + +++ DL+ L + + + Y ++ + +H Sbjct: 205 K--IIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 261 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH----ASVGTHGYMAPEVLQK-- 364 +V+ DLKPAN L+ G +++ D G+A + VGT YM PE ++ Sbjct: 262 HGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 320 Query: 365 --------GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 +D +SLGC+L+ + G +PF+Q + + +E PD Sbjct: 321 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDI 380 Query: 417 FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 +L+ +L+ L+RD +R+ E+ P+ + Sbjct: 381 PEKDLQDVLKCCLKRDPKQRISI-----PELLAHPYVQ 413 >3G0E-A nrPDB Length = 336 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 62/282 (21%), Positives = 104/282 (36%), Gaps = 34/282 (12%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEV-----YGCRKADTGKMYAMKCLDKKRIKMKQGETLAL 237 N S + +G G FG+V YG K+D A+K L K + + E L Sbjct: 40 KWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KPSAHLTEREALMS 98 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG---------- 287 +++ L G+ IV + A I + GDL L + Sbjct: 99 ELKVLSYL---GNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSP 155 Query: 288 --------VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA 339 D+ ++ ++ G+ + ++ ++RDL NILL +I D GLA Sbjct: 156 AIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLA 215 Query: 340 CDFSKKKPHASVGTHG----YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQH 394 D + G +MAPE + V Y +D +S G L++L G SP+ Sbjct: 216 RDIKNDSNYVVKGNARLPVKWMAPESIFNCV-YTFESDVWSYGIFLWELFSLGSSPYPGM 274 Query: 395 KTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 D + + P+ E+ +++ D +R Sbjct: 275 PV-DSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKR 315 >2PL0-A nrPDB Length = 289 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 57/267 (21%), Positives = 100/267 (37%), Gaps = 18/267 (6%) Query: 176 QWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL 235 Q E + + +G G FGEV+ A+K L + + Sbjct: 10 QKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNG-HTKVAVKSLKQGSMSPDAF--- 65 Query: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEAD 293 +L+ +V + YA T + + I + M G L L + Sbjct: 66 ----LAEANLMKQLQHQRLVRL-YAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINK 120 Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG- 352 + AA+I G+ + R ++RDL+ ANIL+ + +I+D GLA + A G Sbjct: 121 LLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA 180 Query: 353 --THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTM 409 + APE + G + +D +S G +L +++ G P+ + I + Sbjct: 181 KFPIKWTAPEAINYG-TFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEV--IQNLERGY 237 Query: 410 AVELPDSFSPELRSLLEGLLQRDVNRR 436 + PD+ EL L+ + R Sbjct: 238 RMVRPDNCPEELYQLMRLCWKERPEDR 264 >3FI2-A nrPDB Length = 353 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 61/312 (19%), Positives = 116/312 (37%), Gaps = 59/312 (18%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + + + IG G G V A + A+K L + Q +T A L L+ Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR----PFQNQTHAKRAYRELVLMK 78 Query: 248 TGDCPFIVCMSYAF------HTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 + I+ + F + +++LM+ +L + M + ++ Sbjct: 79 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME--LDHERMSYLLYQM 135 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC-DFSKKKPHASVGTHGYMAPE 360 + G++H+H+ +++RDLKP+NI++ ++I D GLA + V T Y APE Sbjct: 136 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 195 Query: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSFSP 419 V+ G+ Y + D +S+GC++ +++R F D+ +++ T E P Sbjct: 196 VIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 254 Query: 420 E--------------------------------------LRSLLEGLLQRDVNRRLGCLG 441 R LL +L D +R+ Sbjct: 255 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI---- 310 Query: 442 RGAQEVKESPFF 453 + + P+ Sbjct: 311 -SVDDALQHPYI 321 >4YFF-A nrPDB Length = 311 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 65/261 (24%), Positives = 109/261 (41%), Gaps = 13/261 (4%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 + HL +++ H IIG G FG+VY R K+ A+K K + E Sbjct: 36 HFHLQLSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCRE--- 90 Query: 243 LSLVSTGDCPFIVCMSYAF-HTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAA-E 300 +S++ + P ++ A + P + + + ++GG L L + + + A + Sbjct: 91 VSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVD 150 Query: 301 IILGLEHMHN--RFVVYRDLKPANILLDEHGHVRISDLGLACDF---SKKKPHASVGTHG 355 + G+E++HN + +++RDL NILL E GH ++D G + + G Sbjct: 151 VAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 210 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPD 415 +MAPEV + Y AD FS L+++L G PF K D + + Sbjct: 211 WMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPA-AAAADMAYHHIRPPIGY 269 Query: 416 SFSPELRSLLEGLLQRDVNRR 436 S + SLL R Sbjct: 270 SIPKPISSLLIRGWNACPEGR 290 >2WTK-C nrPDB Length = 305 Score = 207 bits (526), Expect = 2e-53, Method: Composition-based stats. Identities = 61/305 (20%), Positives = 127/305 (41%), Gaps = 31/305 (10%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + + + ++G G +G+V ++T A+K L KK+++ N + + L+ Sbjct: 4 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEA--NVKKEIQLLR 61 Query: 248 TGDCPFIVCMSYAF--HTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADMRFYAAEIIL 303 ++ + K+ +++ G + L F Y ++I Sbjct: 62 RLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKRFPVCQAHGYFCQLID 120 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK----KKPHASVGTHGYMAP 359 GLE++H++ +V++D+KP N+LL G ++IS LG+A S G+ + P Sbjct: 121 GLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPP 180 Query: 360 EVLQKGVAYD-SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS 418 E+ + D +S G L+ + G PF + +++ + +P Sbjct: 181 EIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGD---NIYKLFENIGKGSYAIPGDCG 237 Query: 419 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPL--IPPRGE 476 P L LL+G+L+ + +R +++++ +FR +K+PP +P Sbjct: 238 PPLSDLLKGMLEYEPAKRFSI-----RQIRQHSWFR---------KKHPPAEAPVPIPPS 283 Query: 477 VNAAD 481 + D Sbjct: 284 PDTKD 288 >5HIE-A nrPDB Length = 302 Score = 206 bits (524), Expect = 3e-53, Method: Composition-based stats. Identities = 56/264 (21%), Positives = 114/264 (43%), Gaps = 23/264 (8%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 + + +V + IG G FG VY + A+K L ++++ + E L + Sbjct: 30 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFKNEVGVLRKTRH 86 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ-HGVFSEADMRFYAAEI 301 ++++ + + T +L+ + G L++HL F + A + Sbjct: 87 VNIL----------LFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQT 136 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA----CDFSKKKPHASVGTHGYM 357 G++++H + +++RDLK NI L E V+I D GLA + G+ +M Sbjct: 137 AQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM 196 Query: 358 APEVL--QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP- 414 APEV+ Q Y +D ++ G +L++L+ G P+ +D+ ++ +L Sbjct: 197 APEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSK 256 Query: 415 --DSFSPELRSLLEGLLQRDVNRR 436 + ++ L+ L++ + R Sbjct: 257 VRSNCPKAMKRLMAECLKKKRDER 280 >3HMP-A nrPDB Length = 342 Score = 206 bits (524), Expect = 3e-53, Method: Composition-based stats. Identities = 58/278 (20%), Positives = 117/278 (42%), Gaps = 24/278 (8%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 +S+ + IG GG +V+ ++YA+K ++ + + ++ + L D Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 I+ + T + +++ DL+ L + + + Y ++ + +H Sbjct: 117 K--IIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 173 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH----ASVGTHGYMAPEVLQK-- 364 +V+ DLKPAN L+ G +++ D G+A + VGT YM PE ++ Sbjct: 174 HGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 232 Query: 365 --------GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 +D +SLGC+L+ + G +PF+Q + + +E PD Sbjct: 233 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDI 292 Query: 417 FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 +L+ +L+ L+RD +R+ E+ P+ + Sbjct: 293 PEKDLQDVLKCCLKRDPKQRISI-----PELLAHPYVQ 325 >3I81-A nrPDB Length = 315 Score = 205 bits (523), Expect = 4e-53, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 117/298 (39%), Gaps = 31/298 (10%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGK-----MYAMKCLDKKRIKMKQGETLAL 237 + ++ R +G+G FG VY K A+K +++ ++ E L Sbjct: 12 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFL-- 69 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSE------ 291 S++ +C +V + I++LM GDL +L E Sbjct: 70 ---NEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLA 126 Query: 292 ----ADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 347 + M A EI G+ +++ V+RDL N ++ E V+I D G+ D + Sbjct: 127 PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDY 186 Query: 348 HASVG----THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEI 402 + G +M+PE L+ GV + + +D +S G +L+++ P++ + Sbjct: 187 YRKGGKGLLPVRWMSPESLKDGV-FTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRF 245 Query: 403 DRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLG--RGAQEVKESPFFRSLDW 458 + ++ PD+ L L+ Q + R L +E E P FR + + Sbjct: 246 --VMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEME-PGFREVSF 300 >1U59-A nrPDB Length = 287 Score = 205 bits (523), Expect = 4e-53, Method: Composition-based stats. Identities = 55/261 (21%), Positives = 107/261 (40%), Gaps = 19/261 (7%) Query: 186 LTMNDFSVHRI-IGRGGFGEVYGCRKADTGKM--YAMKCLDKKRIKMKQGETLALNERIM 242 L ++ + I +G G FG V K A+K L + K E + Sbjct: 6 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMM-----RE 60 Query: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADMRFYAAEI 301 ++ D P+IV + + L ++++ GG LH L + +++ ++ Sbjct: 61 AQIMHQLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQV 119 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----Y 356 +G++++ + V+RDL N+LL + +ISD GL+ + + + G + Sbjct: 120 SMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKW 179 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPD 415 APE + + S +D +S G +++ L G P+++ K + + +E P Sbjct: 180 YAPECINF-RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF--IEQGKRMECPP 236 Query: 416 SFSPELRSLLEGLLQRDVNRR 436 PEL +L+ R Sbjct: 237 ECPPELYALMSDCWIYKWEDR 257 >1TKI-A nrPDB Length = 321 Score = 205 bits (522), Expect = 4e-53, Method: Composition-based stats. Identities = 56/271 (20%), Positives = 115/271 (42%), Gaps = 18/271 (6%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + +GRG FG V+ C + + K Y K + K T + + +S+++ Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKG-------TDQVLVKKEISILNI 57 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEH 307 I+ + +F + ++L I + ++G D+ ++ +E ++ Y ++ L+ Sbjct: 58 ARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQF 117 Query: 308 MHNRFVVYRDLKPANILLDEH--GHVRISDLGLACDFSKKKPHASVGT-HGYMAPEVLQK 364 +H+ + + D++P NI+ ++I + G A + T Y APEV + Sbjct: 118 LHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEV-HQ 176 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD-KHEIDRMTLTMAVELPDSFSPELRS 423 ++ D +SLG +++ LL G +PF + I T E S E Sbjct: 177 HDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMD 236 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 ++ LL ++ R+ A E + P+ + Sbjct: 237 FVDRLLVKERKSRM-----TASEALQHPWLK 262 >2HK5-A nrPDB Length = 270 Score = 205 bits (522), Expect = 5e-53, Method: Composition-based stats. Identities = 51/268 (19%), Positives = 104/268 (38%), Gaps = 20/268 (7%) Query: 176 QWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGC-RKADTGKMYAMKCLDKKRIKMKQGET 234 Q + + + + +G G FGEV+ T A+K + + ++ Sbjct: 2 QKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT--KVAVKTMKPGSMSVEAF-- 57 Query: 235 LALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS--QHGVFSEA 292 +++ T +V + T + + I + M G L L + Sbjct: 58 -----LAEANVMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLP 111 Query: 293 DMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG 352 + ++A+I G+ + R ++RDL+ ANIL+ +I+D GLA + A G Sbjct: 112 KLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREG 171 Query: 353 ---THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLT 408 + APE + G ++ +D +S G +L +++ G P+ + I + Sbjct: 172 AKFPIKWTAPEAINFG-SFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEV--IRALERG 228 Query: 409 MAVELPDSFSPELRSLLEGLLQRDVNRR 436 + P++ EL +++ + R Sbjct: 229 YRMPRPENCPEELYNIMMRCWKNRPEER 256 >5FM2-A nrPDB Length = 355 Score = 205 bits (522), Expect = 5e-53, Method: Composition-based stats. Identities = 51/288 (17%), Positives = 112/288 (38%), Gaps = 42/288 (14%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGC-----RKADTGKMYAMKCLDKKRIKMKQGETLAL 237 + + + +G G FG+V + A+K L + + Sbjct: 58 KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSE-----LR 112 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ------------ 285 + +++ + P ++ + A L I++ G L L + Sbjct: 113 DLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSG 172 Query: 286 ------------HGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRI 333 + D+ +A +I G++++ +V+RDL NIL+ E ++I Sbjct: 173 GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI 232 Query: 334 SDLGLACDFSKKKPHASVG----THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GH 388 SD GL+ D ++ + +MA E L + Y + +D +S G +L++++ G Sbjct: 233 SDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGG 291 Query: 389 SPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 +P+ + + + +E PD+ S E+ L+ +++ ++R Sbjct: 292 NPYPGIPPE--RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKR 337 >5AP3-A nrPDB Length = 313 Score = 204 bits (520), Expect = 9e-53, Method: Composition-based stats. Identities = 58/278 (20%), Positives = 117/278 (42%), Gaps = 24/278 (8%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 +S+ + IG GG +V+ ++YA+K ++ + + ++ + L D Sbjct: 30 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 I+ + T + +++ DL+ L + + + Y ++ + +H Sbjct: 89 K--IIRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 145 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH----ASVGTHGYMAPEVLQK-- 364 +V+ DLKPAN L+ G +++ D G+A + VGT YM PE ++ Sbjct: 146 HGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 204 Query: 365 --------GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 +D +SLGC+L+ + G +PF+Q + + +E PD Sbjct: 205 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDI 264 Query: 417 FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 +L+ +L+ L+RD +R+ E+ P+ + Sbjct: 265 PEKDLQDVLKCCLKRDPKQRISI-----PELLAHPYVQ 297 >5Y86-A nrPDB Length = 588 Score = 204 bits (519), Expect = 1e-52, Method: Composition-based stats. Identities = 71/336 (21%), Positives = 125/336 (37%), Gaps = 75/336 (22%) Query: 184 IHLTMN----DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-DKKRIKMKQGETLALN 238 IH+ + + V +IIG+G FG+V + A+K + ++KR + E + + Sbjct: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 Query: 239 ERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRF 296 E L ++ M +F + + +L++ DL+ + ++ FS +R Sbjct: 258 E--HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQLVRK 314 Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGH--VRISDLGLACDFSKKKPHASVGTH 354 +A I+ L+ +H +++ DLKP NILL HG ++ D G +C F +K + + + Sbjct: 315 FAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC-FEYQKLYTYIQSR 373 Query: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE-- 412 Y APE++ G Y + D +S GC+L +LL G F D+ L M Sbjct: 374 FYRAPEIIL-GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 Query: 413 ---------------LPDSFS------------------------PELRS---------- 423 +P S P + Sbjct: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 Query: 424 -----LLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 L+ L D + RL + P+ Sbjct: 493 YLFIEFLKRCLHWDPSARL-----TPAQALRHPWIS 523 >3OMV-A nrPDB Length = 307 Score = 204 bits (519), Expect = 1e-52, Method: Composition-based stats. Identities = 60/266 (22%), Positives = 112/266 (42%), Gaps = 19/266 (7%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 IG G FG VY + A+K L +Q + R ++++ I+ Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAF----RNEVAVLRKTRHVNIL- 95 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLS-QHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315 + + T D L+ + G L+ HL Q F + A + G++++H + +++ Sbjct: 96 LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIH 155 Query: 316 RDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV----GTHGYMAPEVL--QKGVAYD 369 RD+K NI L E V+I D GLA S+ V G+ +MAPEV+ Q + Sbjct: 156 RDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFS 215 Query: 370 SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP---DSFSPELRSLLE 426 +D +S G +L++L+ G P+ +D+ + +L + ++ L+ Sbjct: 216 FQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA 275 Query: 427 GLLQRDVNRR-LGCLGRGAQEVKESP 451 +++ R L + E+ + Sbjct: 276 DCVKKVKEERPLFPQILSSIELLQHS 301 >2PSQ-A nrPDB Length = 370 Score = 204 bits (519), Expect = 1e-52, Method: Composition-based stats. Identities = 54/282 (19%), Positives = 111/282 (39%), Gaps = 35/282 (12%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGC----RKADTGKM---YAMKCLDKKRIKMKQGETL 235 + ++ + +G G FG+V D K A+K L K K L Sbjct: 75 KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLSDL 133 Query: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV------- 288 +M + G I+ + A L I++ + G+L +L Sbjct: 134 VSEMEMMKMI---GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSY 190 Query: 289 ---------FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA 339 + D+ ++ G+E++ ++ ++RDL N+L+ E+ ++I+D GLA Sbjct: 191 DINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLA 250 Query: 340 CDFSKKKPHASVGT----HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQH 394 D + + +MAPE L V Y +D +S G +++++ G SP+ Sbjct: 251 RDINNIDYYKKTTNGRLPVKWMAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYPGI 309 Query: 395 KTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 ++ ++ + ++ P + + EL ++ ++R Sbjct: 310 PVEELFKL--LKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 349 >1ZXE-A nrPDB Length = 303 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 60/286 (20%), Positives = 120/286 (41%), Gaps = 46/286 (16%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +DF ++G+G FG+V R A + YA+K + + E + L+++ Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKI-------RHTEEKLSTILSEVMLLAS 58 Query: 249 GDCPFIVCMSYAFHT-------------PDKLSFILDLMNGGDLHYHLSQHGVFSE-ADM 294 + ++V A+ L ++ L+ + + + + Sbjct: 59 LNHQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEY 118 Query: 295 RFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF------------ 342 +I+ L ++H++ +++R+LKP NI +DE +V+I D GLA + Sbjct: 119 WRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQ 178 Query: 343 ----SKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 S +++GT Y+A EVL Y+ D +SLG + F+++ PF + Sbjct: 179 NLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPF--STGME 233 Query: 399 KHEIDRMTLTMAVELPDSFSPEL----RSLLEGLLQRDVNRRLGCL 440 + I + ++++E P F + ++ L+ D N+R G Sbjct: 234 RVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGAR 279 >4PWN-A nrPDB Length = 274 Score = 203 bits (517), Expect = 2e-52, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 120/269 (44%), Gaps = 21/269 (7%) Query: 196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIV 255 IGRG F VY +T A L +++ + + ++ L P IV Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGL----QHPNIV 72 Query: 256 CMSYAFHT----PDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNR 311 ++ + + + +LM G L +L + V +R + +I+ GL+ +H R Sbjct: 73 RFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTR 132 Query: 312 --FVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGVA 367 +++RDLK NI + G V+I DLGLA + + +GT +MAPE+ ++ Sbjct: 133 TPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYEE--K 190 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS-PELRSLLE 426 YD S D ++ G + ++ P+ + + R+T + D + PE++ ++E Sbjct: 191 YDESVDVYAFGMCMLEMATSEYPYSECQNA-AQIYRRVTSGVKPASFDKVAIPEVKEIIE 249 Query: 427 GLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 G ++++ + R +++ FF+ Sbjct: 250 GCIRQNKDERYSI-----KDLLNHAFFQE 273 >2ZMD-A nrPDB Length = 390 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 116/278 (41%), Gaps = 24/278 (8%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 +S+ + IG GG +V+ ++YA+K ++ + + ++ + L D Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 I+ + T + +++ DL+ L + + + Y ++ + +H Sbjct: 117 K--IIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 173 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH----ASVGTHGYMAPEVLQK-- 364 +V+ DLKPAN L+ G +++ D G+A + VG YM PE ++ Sbjct: 174 HGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMS 232 Query: 365 --------GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 +D +SLGC+L+ + G +PF+Q + + +E PD Sbjct: 233 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDI 292 Query: 417 FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 +L+ +L+ L+RD +R+ E+ P+ + Sbjct: 293 PEKDLQDVLKCCLKRDPKQRISI-----PELLAHPYVQ 325 >2OZO-A nrPDB Length = 613 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 109/278 (39%), Gaps = 23/278 (8%) Query: 168 SDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKM--YAMKCLDKK 225 SD K +L + D +G G FG V K A+K L + Sbjct: 320 SDPE-ELKDKKLFLKRDNLLIADIE----LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG 374 Query: 226 RIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS- 284 K E + ++ D P+IV + + L ++++ GG LH L Sbjct: 375 TEKADTEEMM-----REAQIMHQLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVG 428 Query: 285 QHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK 344 + +++ ++ +G++++ + V+R+L N+LL + +ISD GL+ Sbjct: 429 KREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGA 488 Query: 345 KKPHASVGTHG-----YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 + + + G + APE + + S +D +S G +++ L G P+++ K + Sbjct: 489 DDSYYTARSAGKWPLKWYAPECINF-RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE 547 Query: 399 KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + +E P PEL +L+ R Sbjct: 548 VMAF--IEQGKRMECPPECPPELYALMSDCWIYKWEDR 583 >3N9X-A nrPDB Length = 432 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 69/376 (18%), Positives = 135/376 (35%), Gaps = 99/376 (26%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 N+H+ +++ + +IGRG +G VY +T K A+K +++ M + Sbjct: 21 NVHVP-DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNR----MFEDLIDCKRILRE 75 Query: 243 LSLVSTGDCPFIVCMSYAFHTPD-----KLSFILDLMNGGDLHYHLSQHGVFSEADMRFY 297 +++++ +I+ + D +L +L++ + DL +E ++ Sbjct: 76 ITILNRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEEHIKTI 134 Query: 298 AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP---------- 347 ++LG +H +++RDLKPAN LL++ V++ D GLA + +K Sbjct: 135 LYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEEN 194 Query: 348 --------------HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL-------- 385 + V T Y APE++ Y S D +S GC+ +LL Sbjct: 195 EEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHIN 254 Query: 386 ---RGHSPFRQH-----------------KTKDKHEIDRMTLTMAVE------------- 412 F +D+ I + E Sbjct: 255 DPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIK 314 Query: 413 ----LP-----------DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 P S S + +LLE +L+ + N+R+ + + P+ + + Sbjct: 315 YIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITI-----DQALDHPYLKDVR 369 Query: 458 WQMVFL---QKYPPPL 470 + + +K P Sbjct: 370 KKKLENFSTKKIILPF 385 >3BBT-B nrPDB Length = 328 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 53/270 (19%), Positives = 112/270 (41%), Gaps = 19/270 (7%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY----AMKCLDKKRIKMKQGETLALNERI 241 L + +++G G FG VY G+ A+K L++ E + Sbjct: 12 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFM-----D 66 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAE 300 ++++ D P +V + +P + + LM G L ++ +H + + + Sbjct: 67 EALIMASMDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQ 125 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDF-SKKKPHASVG---THGY 356 I G+ ++ R +V+RDL N+L+ HV+I+D GLA +K + + G + Sbjct: 126 IAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKW 185 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPD 415 MA E + + +D +S G +++L+ G P+ T++ ++ + + P Sbjct: 186 MALECIHY-RKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDL--LEKGERLPQPP 242 Query: 416 SFSPELRSLLEGLLQRDVNRRLGCLGRGAQ 445 + ++ ++ D + R A+ Sbjct: 243 ICTIDVYMVMVKCWMIDADSRPKFKELAAE 272 >3QUP-A nrPDB Length = 323 Score = 202 bits (514), Expect = 4e-52, Method: Composition-based stats. Identities = 53/282 (18%), Positives = 103/282 (36%), Gaps = 29/282 (10%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTG---KMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 F++ R++G+G FG V + A+K L I E M Sbjct: 25 FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKE--- 81 Query: 248 TGDCPFIVCMSYAFHT---PDKLSF---ILDLMNGGDLHYHLSQHGV------FSEADMR 295 D P + + +L IL M GDLH L + + Sbjct: 82 -FDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLV 140 Query: 296 FYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTH 354 + +I G+E++ +R ++RDL N +L E V ++D GL+ + + Sbjct: 141 RFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASK 200 Query: 355 ---GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMA 410 ++A E L + Y +D ++ G +++++ G +P+ + + + + Sbjct: 201 LPVKWLALESLADNL-YTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNY--LIGGNR 257 Query: 411 VELPDSFSPELRSLLEGLLQRDVNRR--LGCLGRGAQEVKES 450 ++ P E+ L+ D +R CL + + Sbjct: 258 LKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGH 299 >4IDT-A nrPDB Length = 356 Score = 202 bits (514), Expect = 4e-52, Method: Composition-based stats. Identities = 66/287 (22%), Positives = 115/287 (40%), Gaps = 29/287 (10%) Query: 176 QWKNVELNIHLTMNDFSVHRI---------IGRGGFGEVYGCRKADTGKMYAMKCLDKKR 226 + V L L D+ +GRG FGEV+ TG A+K + + Sbjct: 52 DNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEV 111 Query: 227 IKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH 286 + ++ L + P IV + A ++ ++L+ GG L + + Sbjct: 112 FRAEE-----------LMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQ 160 Query: 287 GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHG-HVRISDLGLACDFSKK 345 G E +Y + + GLE++H+R +++ D+K N+LL G H + D G A Sbjct: 161 GCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPD 220 Query: 346 KPHASV-------GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 + GT +MAPEV+ G + D+ D +S CM+ +L G P+ Q Sbjct: 221 GLGKDLLTGDYIPGTETHMAPEVVL-GRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGP 279 Query: 399 KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQ 445 E+P S +P ++ L+++ R+ G + Sbjct: 280 LCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGK 326 >4K33-A nrPDB Length = 325 Score = 202 bits (514), Expect = 4e-52, Method: Composition-based stats. Identities = 54/282 (19%), Positives = 108/282 (38%), Gaps = 35/282 (12%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGK-------MYAMKCLDKKRIKMKQGETL 235 L+ ++ + +G G FG+V K A+K L K K L Sbjct: 30 KWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKML-KDDATDKDLSDL 88 Query: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV------- 288 +M + G I+ + A L +++ G+L L Sbjct: 89 VSEMEMMKMI---GKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSF 145 Query: 289 ---------FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA 339 + D+ A ++ G+E++ ++ ++RDL N+L+ E ++I+D GLA Sbjct: 146 DTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLA 205 Query: 340 CDFSKKKPHASVGT----HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQH 394 D + +MAPE L V Y +D +S G +L+++ G SP+ Sbjct: 206 RDVHNLDYYKETTNGRLPVKWMAPEALFDRV-YTHQSDVWSFGVLLWEIFTLGGSPYPGI 264 Query: 395 KTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 ++ ++ + ++ P + + +L ++ ++R Sbjct: 265 PVEELFKL--LKEGHRMDKPANCTHDLYMIMRECWHAAPSQR 304 >6O6Q-A nrPDB Length = 335 Score = 202 bits (514), Expect = 5e-52, Method: Composition-based stats. Identities = 72/319 (22%), Positives = 126/319 (39%), Gaps = 55/319 (17%) Query: 177 WKNVELNIHLT-MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL 235 W +LNI ++ + R +GRG + EV+ + + +K L + K + E Sbjct: 28 WDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIKREIS 87 Query: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHLSQHGVFSEAD 293 L + D P I+ M P I + +N D + F++ D Sbjct: 88 ILKNLV--------DGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL---YPTFTDYD 136 Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGH-VRISDLGLACDFSKK-KPHASV 351 +RFY E++ L++ H+ +++RD+KP N+++D +R+ D GLA + + + V Sbjct: 137 IRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRV 196 Query: 352 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKT--------------- 396 + + PE+L YD S D +S GCML ++ PF K+ Sbjct: 197 ASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSK 256 Query: 397 --------------KDKHEIDRMTLTMAVELP-----DSFSPELRSLLEGLLQRDVNRRL 437 ++ +I V D S E L++ LL+ D RL Sbjct: 257 NFKKYLEKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERL 316 Query: 438 GCLGRGAQEVKESPFFRSL 456 A+E + +F + Sbjct: 317 -----TAKEAMKHAYFDPI 330 >6E4F-A nrPDB Length = 290 Score = 202 bits (513), Expect = 6e-52, Method: Composition-based stats. Identities = 47/260 (18%), Positives = 109/260 (41%), Gaps = 18/260 (6%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKM-YAMKCLDKKRIKMKQGETLALNERI 241 + + D + + +G G FG V + G+ A+K + + + E + E Sbjct: 25 SWEIDPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMS----EDEFIEEAK 78 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ-HGVFSEADMRFYAAE 300 ++ +S +V + + I + M G L +L + F + + Sbjct: 79 VMMNLSHEK---LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD 135 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GYM 357 + +E++ ++ ++RDL N L+++ G V++SD GL+ + +SVG+ + Sbjct: 136 VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWS 195 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 PEVL + S +D ++ G +++++ G P+ + + E + + + P Sbjct: 196 PPEVLMYS-KFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAE--HIAQGLRLYRPHL 252 Query: 417 FSPELRSLLEGLLQRDVNRR 436 S ++ +++ + R Sbjct: 253 ASEKVYTIMYSCWHEKADER 272 >4HVI-A nrPDB Length = 314 Score = 201 bits (512), Expect = 7e-52, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 108/284 (38%), Gaps = 40/284 (14%) Query: 191 FSVHRIIGRGGFGEVYGCR----KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 +G+G FG V CR +TG + A+K L G + + + ++ Sbjct: 12 LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS------GPDQQRDFQREIQIL 65 Query: 247 STGDCPFIVCMSYAFHTPDK--LSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIIL 303 FIV + P + L +++ + G L L +H + + Y+++I Sbjct: 66 KALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICK 125 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMA 358 G+E++ +R V+RDL NIL++ HV+I+D GLA K + V G + A Sbjct: 126 GMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYA 185 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMT------------ 406 PE L + + +D +S G +L++L + E RM Sbjct: 186 PESLSDNI-FSRQSDVWSFGVVLYELFT----YCDKSCSPSAEFLRMMGSERDVPALSRL 240 Query: 407 -----LTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQ 445 + P + E+ L++ R G Q Sbjct: 241 LELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQ 284 >3LZB-A nrPDB Length = 327 Score = 201 bits (512), Expect = 7e-52, Method: Composition-based stats. Identities = 57/261 (21%), Positives = 108/261 (41%), Gaps = 19/261 (7%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY----AMKCLDKKRIKMKQGETLALNERI 241 L +F +++G G FG VY G+ A+K L + E L Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEIL-----D 66 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAE 300 ++++ D P + + T + I LM G L ++ +H + + + Sbjct: 67 EAYVMASVDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ 125 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVG--THGY 356 I G+ ++ +R +V+RDL N+L+ HV+I+D GLA +K+ HA G + Sbjct: 126 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 185 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPD 415 MA E + + Y +D +S G +++L+ G P+ + I + + P Sbjct: 186 MALESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSI--LEKGERLPQPP 242 Query: 416 SFSPELRSLLEGLLQRDVNRR 436 + ++ ++ D + R Sbjct: 243 ICTIDVYMIMRKCWMIDADSR 263 >5GNK-A nrPDB Length = 297 Score = 201 bits (511), Expect = 9e-52, Method: Composition-based stats. Identities = 57/261 (21%), Positives = 109/261 (41%), Gaps = 19/261 (7%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY----AMKCLDKKRIKMKQGETLALNERI 241 L +F +++G G FG VY G+ A+K L + E L Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEIL-----D 70 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAE 300 ++++ D P + + T + I+ LM G L ++ +H + + + Sbjct: 71 EAYVMASVDNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ 129 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVG--THGY 356 I G+ ++ +R +V+RDL N+L+ HV+I+D GLA +K+ HA G + Sbjct: 130 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 189 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPD 415 MA E + + Y +D +S G +++L+ G P+ + I + + P Sbjct: 190 MALESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSI--LEKGERLPQPP 246 Query: 416 SFSPELRSLLEGLLQRDVNRR 436 + ++ ++ D + R Sbjct: 247 ICTIDVYMIMVKCWMIDADSR 267 >4LRM-A nrPDB Length = 334 Score = 200 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 58/261 (22%), Positives = 109/261 (41%), Gaps = 16/261 (6%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY----AMKCLDKKRIKMKQGETLALNERI 241 L +F +++G G FG VY G+ A+K L + E L+E Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE--ILDEAY 73 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAE 300 +++ V P + + T + I LM G L ++ +H + + + Sbjct: 74 VMASVDNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ 132 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVG--THGY 356 I G+ ++ +R +V+RDL N+L+ HV+I+D GLA +K+ HA G + Sbjct: 133 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 192 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPD 415 MA E + + Y +D +S G +++L+ G P+ + I + + P Sbjct: 193 MALESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSI--LEKGERLPQPP 249 Query: 416 SFSPELRSLLEGLLQRDVNRR 436 + ++ ++ D + R Sbjct: 250 ICTIDVYMIMVKCWMIDADSR 270 >4XI2-A nrPDB Length = 446 Score = 200 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 47/260 (18%), Positives = 108/260 (41%), Gaps = 18/260 (6%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKM-YAMKCLDKKRIKMKQGETLALNERI 241 + + D + + +G G FG V + G+ A+K + + + E + E Sbjct: 181 SWEIDPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIREGSMS----EDEFIEEAK 234 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ-HGVFSEADMRFYAAE 300 ++ +S +V + + I + M G L +L + F + + Sbjct: 235 VMMNLSHEK---LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD 291 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GYM 357 + +E++ ++ ++RDL N L+++ G V++SD GL+ + +SVG+ + Sbjct: 292 VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWS 351 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 PEVL + S +D ++ G +++++ G P+ + + E + + + P Sbjct: 352 PPEVLMYS-KFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAE--HIAQGLRLYRPHL 408 Query: 417 FSPELRSLLEGLLQRDVNRR 436 S + +++ + R Sbjct: 409 ASERVYTIMYSCWHEKADER 428 >3AOX-A nrPDB Length = 344 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 58/272 (21%), Positives = 109/272 (40%), Gaps = 28/272 (10%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCR-----KADTGKMYAMKCLDKKRIKMKQGETLALNE 239 + + ++ R +G G FGEVY + + A+K L + + +Q E L E Sbjct: 43 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPE--VCSEQDELDFLME 100 Query: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-------FSEA 292 +++S + IV +L+LM GGDL L + + Sbjct: 101 ALIIS---KFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAML 157 Query: 293 DMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHG---HVRISDLGLACDFSKKKPHA 349 D+ A +I G +++ ++RD+ N LL G +I D G+A D + + Sbjct: 158 DLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYR 217 Query: 350 SVGTH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDR 404 G +M PE +G+ + S D +S G +L+++ G+ P+ ++ E Sbjct: 218 KGGCAMLPVKWMPPEAFMEGI-FTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEF-- 274 Query: 405 MTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 +T ++ P + + ++ Q R Sbjct: 275 VTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDR 306 >3NIE-A nrPDB Length = 429 Score = 200 bits (509), Expect = 2e-51, Method: Composition-based stats. Identities = 67/373 (17%), Positives = 128/373 (34%), Gaps = 101/373 (27%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ + +IGRG +G VY + K A+K +++ M + +++++ Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNR----MFEDLIDCKRILREITILNR 83 Query: 249 GDCPFIVCMSYAFHTPD-----KLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 +I+ + D +L +L++ + DL +E ++ ++L Sbjct: 84 LKSDYIIRLHDLIIPEDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEQHVKTILYNLLL 142 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP---------------- 347 G + +H +++RDLKPAN LL++ V+I D GLA + K Sbjct: 143 GEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEP 202 Query: 348 -----------HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL----------- 385 + V T Y APE++ Y +S D +S GC+ +LL Sbjct: 203 GPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPT 262 Query: 386 RGHSPFRQH-----------------KTKDKHEIDRMTLTMAVE---------------- 412 F +D+ I + E Sbjct: 263 NRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIK 322 Query: 413 -LP-----------DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQM 460 P S S E LLE +L+ + +R+ + P+ + + + Sbjct: 323 LFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITI-----DKALSHPYLKDVRKEN 377 Query: 461 VFL---QKYPPPL 470 + +K P Sbjct: 378 LENFSTEKIILPF 390 >4Y93-A nrPDB Length = 446 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 45/260 (17%), Positives = 107/260 (41%), Gaps = 18/260 (6%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKM-YAMKCLDKKRIKMKQGETLALNERI 241 + + D + + +G G FG V + G+ A+K + + + E + E Sbjct: 182 SWEIDPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMS----EDEFIEEAK 235 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ-HGVFSEADMRFYAAE 300 ++ +S +V + + I + M G L +L + F + + Sbjct: 236 VMMNLSHEK---LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD 292 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---GYM 357 + +E++ ++ ++RDL N L+++ G V++SD G+ + +S G+ + Sbjct: 293 VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWA 352 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 +PEVL + S +D ++ G +++++ G P+ + + E + + + P Sbjct: 353 SPEVLMYS-KFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAE--HIAQGLRLPRPHL 409 Query: 417 FSPELRSLLEGLLQRDVNRR 436 S + +++ + R Sbjct: 410 ASERVYAIMYSCWHEKADER 429 >4MD7-E nrPDB Length = 391 Score = 199 bits (505), Expect = 4e-51, Method: Composition-based stats. Identities = 75/340 (22%), Positives = 134/340 (39%), Gaps = 63/340 (18%) Query: 169 DKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIK 228 D + +W N +D+ + R +GRG + EV+ + +K Sbjct: 25 DYESHVVEWGN--------QDDYQLVRKLGRGKYSEVFEAINITNNEK--------VVVK 68 Query: 229 MKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHLSQH 286 + + +R + L + P I+ ++ P + + + +N D + Sbjct: 69 ILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---Y 125 Query: 287 GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKK 345 ++ D+RFY EI+ L++ H+ +++RD+KP N+++D EH +R+ D GLA + Sbjct: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 185 Query: 346 KPH-ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR-QHKTKDK---- 399 + + V + + PE+L YD S D +SLGCML ++ PF H D+ Sbjct: 186 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245 Query: 400 ----------HEIDRMTLTMAVELPDS--------------------FSPELRSLLEGLL 429 ID+ + + D SPE L+ LL Sbjct: 246 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLL 305 Query: 430 QRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPP 469 + D RL A+E E P+F ++ + P Sbjct: 306 RYDHQSRL-----TAREAMEHPYFYTVVKDQARMGSSSMP 340 >3PP0-A nrPDB Length = 338 Score = 198 bits (504), Expect = 6e-51, Method: Composition-based stats. Identities = 53/261 (20%), Positives = 107/261 (40%), Gaps = 19/261 (7%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY----AMKCLDKKRIKMKQGETLALNERI 241 L + +++G G FG VY G+ A+K L + E L Sbjct: 14 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEIL-----D 68 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ-HGVFSEADMRFYAAE 300 +++ P++ + T + + LM G L H+ + G D+ + + Sbjct: 69 EAYVMAGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQ 127 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC--DFSKKKPHASVG--THGY 356 I G+ ++ + +V+RDL N+L+ HV+I+D GLA D + + HA G + Sbjct: 128 IAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKW 187 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPD 415 MA E + + + +D +S G +++L+ G P+ ++ ++ + + P Sbjct: 188 MALESILRRR-FTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDL--LEKGERLPQPP 244 Query: 416 SFSPELRSLLEGLLQRDVNRR 436 + ++ ++ D R Sbjct: 245 ICTIDVYMIMVKCWMIDSECR 265 >5EG3-A nrPDB Length = 334 Score = 198 bits (503), Expect = 7e-51, Method: Composition-based stats. Identities = 55/282 (19%), Positives = 111/282 (39%), Gaps = 35/282 (12%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGC----RKADTGKM---YAMKCLDKKRIKMKQGETL 235 + ++ + +G G FG+V D K A+K L K K L Sbjct: 29 KWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLSDL 87 Query: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV------- 288 +M + G I+ + A L I+ + G+L +L Sbjct: 88 VSEMEMMKMI---GKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSP 144 Query: 289 ---------FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLA 339 + D+ ++ G+E++ ++ ++RDL N+L+ E+ ++I+D GLA Sbjct: 145 DINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLA 204 Query: 340 CDFSK----KKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQH 394 D + K+ +MAPE L V Y +D +S G +++++ G SP+ Sbjct: 205 RDINNIDFFKETTNGRLPVKWMAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYPGI 263 Query: 395 KTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 ++ ++ + ++ P + + EL ++ ++R Sbjct: 264 PVEELFKL--LKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 303 >1AD5-A nrPDB Length = 438 Score = 197 bits (502), Expect = 1e-50, Method: Composition-based stats. Identities = 50/265 (18%), Positives = 103/265 (38%), Gaps = 24/265 (9%) Query: 176 QWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGC-RKADTGKMYAMKCLDKKRIKMKQGET 234 Q + + + + +G G FGEV+ T A+K + + ++ Sbjct: 169 QKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT--KVAVKTMKPGSMSVEAF-- 224 Query: 235 LALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS--QHGVFSEA 292 +++ T +V + T + + I + M G L L + Sbjct: 225 -----LAEANVMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLP 278 Query: 293 DMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG 352 + ++A+I G+ + R ++RDL+ ANIL+ +I+D GLA +K Sbjct: 279 KLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVGAKFP------ 332 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAV 411 + APE + G ++ +D +S G +L +++ G P+ + I + + Sbjct: 333 -IKWTAPEAINFG-SFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEV--IRALERGYRM 388 Query: 412 ELPDSFSPELRSLLEGLLQRDVNRR 436 P++ EL +++ + R Sbjct: 389 PRPENCPEELYNIMMRCWKNRPEER 413 >6FER-A nrPDB Length = 309 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 59/295 (20%), Positives = 114/295 (38%), Gaps = 50/295 (16%) Query: 191 FSVHRIIGRGGFGEVYGCR--------------KADTGK--MYAMKCLDKKRIKMKQGET 234 + +G G FGEV+ C + + A+K L K + + Sbjct: 11 LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDF 70 Query: 235 LALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-------- 286 L + ++S P I+ + T D L I + M GDL+ LS+H Sbjct: 71 LK-----EIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSS 125 Query: 287 --GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK 344 S +++F A +I G++++ + V+RDL N L+ ++ ++I+D G++ + Sbjct: 126 DVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYS 185 Query: 345 KKPHASVG----THGYMAPEVLQKGVAYDSSADWFSLGCMLFK--LLRGHSPFRQHKTKD 398 + G +M+ E + G + +++D ++ G L++ P+ Q + Sbjct: 186 GDYYRIQGRAVLPIRWMSWESILLG-KFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQ 244 Query: 399 KHE------IDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEV 447 E D+ T + P + L+ +RD R QE+ Sbjct: 245 VIENTGEFFRDQGRQTYLPQ-PAICPDSVYKLMLSCWRRDTKNR-----PSFQEI 293 >4LQP-A nrPDB Length = 508 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 90/364 (24%), Positives = 139/364 (38%), Gaps = 70/364 (19%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 DF ++IG+G FGEV +K DTGK+YAMK L K + K ER + ++ Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDV---LAG 158 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 D P++V + Y+F L I++ + GGDL L + +F+E RFY AE IL +E + Sbjct: 159 SDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETI 218 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV----------------G 352 H ++R +KP NIL+D GH+++SD GL+ F K G Sbjct: 219 HKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPG 278 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGC--------------MLFKLLRGHS--------P 390 T Y A D SL ++ G Sbjct: 279 T--YNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFL 336 Query: 391 FRQHKTK-DKHEIDRMTLTMAVELPDSFSPELRSLLEGLL-----------------QRD 432 ++ + + D + + + P S + ++ D Sbjct: 337 YQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAED 396 Query: 433 VNRRLGCLGR-------GAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDI 485 + RRL GA E+K PFFR +DW + ++ P IP + F Sbjct: 397 LIRRLLTHADQRLGRHGGADEIKSHPFFRGVDWNTI--RQVEAPYIPKLSSITDTRFFPT 454 Query: 486 GSFD 489 + Sbjct: 455 DELE 458 >4F0G-A nrPDB Length = 287 Score = 197 bits (501), Expect = 2e-50, Method: Composition-based stats. Identities = 68/265 (25%), Positives = 125/265 (47%), Gaps = 20/265 (7%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE----RI 241 L N+ + IG+GGFG V+ R + A+K L + +GET + + + Sbjct: 16 LADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLI---LGDSEGETEMIEKFQEFQR 72 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYH-LSQHGVFSEADMRFYAAE 300 + ++S + P IV + H P + +++ + GDL++ L + + + Sbjct: 73 EVFIMSNLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLD 130 Query: 301 IILGLEHMHNRF--VVYRDLKPANIL---LDEHGHV--RISDLGLACDFSKKKPHASVGT 353 I LG+E+M N+ +V+RDL+ NI LDE+ V +++D GL+ S +G Sbjct: 131 IALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ-SVHSVSGLLGN 189 Query: 354 HGYMAPEVL-QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRM-TLTMAV 411 +MAPE + + +Y AD +S +L+ +L G PF ++ I+ + + Sbjct: 190 FQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRP 249 Query: 412 ELPDSFSPELRSLLEGLLQRDVNRR 436 +P+ P LR+++E D +R Sbjct: 250 TIPEDCPPRLRNVIELCWSGDPKKR 274 >5O0Y-A nrPDB Length = 579 Score = 197 bits (500), Expect = 2e-50, Method: Composition-based stats. Identities = 60/259 (23%), Positives = 109/259 (42%), Gaps = 24/259 (9%) Query: 202 FGEVYGCRKADTGKMYAMKC--LDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSY 259 F EVY + A+K L+K + ++ E + + D P IV + Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNW-RDEKKENYHKHACREYRIHKELDHPRIVKLYD 355 Query: 260 AF-HTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF--VVYR 316 F D +L+ G DL ++L QH + SE + R +I+ L++++ +++ Sbjct: 356 YFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHY 415 Query: 317 DLKPANILL---DEHGHVRISDLGLACDFSKKKPHAS---------VGTHGYMAPEVLQK 364 DLKP NILL G ++I+D GL+ ++ GT+ Y+ PE Sbjct: 416 DLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVV 475 Query: 365 GV---AYDSSADWFSLGCMLFKLLRGHSPFRQH-KTKDKHEIDRMTLTMAVELPDS--FS 418 G + D +S+G + ++ L G PF + +D + + + V+ P + Sbjct: 476 GKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVT 535 Query: 419 PELRSLLEGLLQRDVNRRL 437 PE ++ + L R+ Sbjct: 536 PEAKAFIRRCLAYRKEDRI 554 >6DBN-A nrPDB Length = 316 Score = 197 bits (500), Expect = 2e-50, Method: Composition-based stats. Identities = 55/277 (19%), Positives = 102/277 (36%), Gaps = 39/277 (14%) Query: 191 FSVHRIIGRGGFGEVYGCR----KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 R +G G FG+V CR +TG+ A+K L K + G + + + ++ Sbjct: 37 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL-----KPESGGNHIADLKKEIEIL 91 Query: 247 STGDCPFIVCMSYAFHTPDK--LSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIIL 303 IV + I++ + G L +L ++ + YA +I Sbjct: 92 RNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICK 151 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMA 358 G++++ +R V+RDL N+L++ V+I D GL K + +V + A Sbjct: 152 GMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYA 211 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTM--------- 409 PE L + Y ++D +S G L +LL + + +M Sbjct: 212 PECLMQSKFY-IASDVWSFGVTLHELLT----YCDSDSSPMALFLKMIGPTHGQMTVTRL 266 Query: 410 --------AVELPDSFSPELRSLLEGLLQRDVNRRLG 438 + P + E+ L+ + + R Sbjct: 267 VNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTS 303 >2I6L-A nrPDB Length = 320 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 117/313 (37%), Gaps = 60/313 (19%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + + +G GG G V+ D K A+K + + Q AL E + ++ Sbjct: 11 SRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI---VLTDPQSVKHALRE---IKIIRR 64 Query: 249 GDCPFIVCMS--------------YAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADM 294 D IV + + + + + + M DL L Q G E Sbjct: 65 LDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLANVLEQ-GPLLEEHA 122 Query: 295 RFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHA---- 349 R + +++ GL+++H+ V++RDLKPAN+ ++ E ++I D GLA H Sbjct: 123 RLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLS 182 Query: 350 -SVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK--------- 399 + T Y +P +L Y + D ++ GC+ ++L G + F ++ Sbjct: 183 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIP 242 Query: 400 --HEIDRMTL----------------TMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLG 441 HE DR L +L S E LE +L RL Sbjct: 243 VVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRL---- 298 Query: 442 RGAQEVKESPFFR 454 A+E P+ Sbjct: 299 -TAEEALSHPYMS 310 >3PLS-A nrPDB Length = 298 Score = 196 bits (498), Expect = 3e-50, Method: Composition-based stats. Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 20/254 (7%) Query: 195 RIIGRGGFGEVYGCRKADTGK---MYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDC 251 R+IG+G FG VY D + A+K L + +M+Q E +M L + Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRIT-EMQQVEAFLREGLLMRGL----NH 81 Query: 252 PFIVCMSYAFHTPDKL-SFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEHMH 309 P ++ + P+ L +L M GDL + + D+ + ++ G+E++ Sbjct: 82 PNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLA 141 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH------GYMAPEVLQ 363 + V+RDL N +LDE V+++D GLA D ++ ++ + A E LQ Sbjct: 142 EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQ 201 Query: 364 KGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 + + +D +S G +L++LL G P+R D + + P+ L Sbjct: 202 TYR-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHF--LAQGRRLPQPEYCPDSLY 258 Query: 423 SLLEGLLQRDVNRR 436 +++ + D R Sbjct: 259 QVMQQCWEADPAVR 272 >5HVK-A nrPDB Length = 315 Score = 196 bits (498), Expect = 3e-50, Method: Composition-based stats. Identities = 56/267 (20%), Positives = 109/267 (40%), Gaps = 28/267 (10%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +D ++G+G FG+ +TG++ MK L ++ E + ++ Sbjct: 14 SDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKEL------IRFDEETQRTFLKEVKVMRC 67 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEH 307 + P ++ + +L+FI + + GG L + + + +A +I G+ + Sbjct: 68 LEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAY 127 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP----------------HASV 351 +H+ +++R+L N L+ E+ +V ++D GLA +K + V Sbjct: 128 LHSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVV 187 Query: 352 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL--RGHSPFRQHKTKDKHEIDRMTLTM 409 G +MAPE++ G +YD D FS G +L +++ P +T D R L Sbjct: 188 GNPYWMAPEMIN-GRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDR 246 Query: 410 AVELPDSFSPELRSLLEGLLQRDVNRR 436 P + P + D +R Sbjct: 247 Y--CPPNCPPSFFPITVRCCDLDPEKR 271 >3ZZW-A nrPDB Length = 289 Score = 195 bits (495), Expect = 6e-50, Method: Composition-based stats. Identities = 61/271 (22%), Positives = 104/271 (38%), Gaps = 34/271 (12%) Query: 192 SVHRIIGRGGFGEVYGCRK-----ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 +G FG+VY + + A+K L K + E R L Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEF-----RHEAMLR 66 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV----------------FS 290 + P +VC+ LS I + GDLH L Sbjct: 67 ARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALE 126 Query: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS 350 D A+I G+E++ + VV++DL N+L+ + +V+ISDLGL + + Sbjct: 127 PPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKL 186 Query: 351 VGT----HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRM 405 +G +MAPE + G + +D +S G +L+++ G P+ + +D E+ R Sbjct: 187 LGNSLLPIRWMAPEAIMYG-KFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRN 245 Query: 406 TLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + PD + +L+ +RR Sbjct: 246 RQV--LPCPDDCPAWVYALMIECWNEFPSRR 274 >5HLW-A nrPDB Length = 299 Score = 195 bits (495), Expect = 6e-50, Method: Composition-based stats. Identities = 61/257 (23%), Positives = 109/257 (42%), Gaps = 22/257 (8%) Query: 193 VHRIIGRGGFGEVYGCRKAD-TGKM--YAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + +IGRG FG VY D GK A+K L+ RI + L E I++ S Sbjct: 24 FNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN--RITDIGEVSQFLTEGIIMKDFS-- 79 Query: 250 DCPFIVCMSY-AFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEH 307 P ++ + + +L M GDL + + D+ + ++ G+++ Sbjct: 80 -HPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKY 138 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS---VGTH---GYMAPEV 361 + ++ V+RDL N +LDE V+++D GLA D K+ ++ G +MA E Sbjct: 139 LASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALES 198 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD-KHEIDRMTLTMAVELPDSFSP 419 LQ + + +D +S G +L++L+ G P+ T D + + + P+ Sbjct: 199 LQT-QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQ---PEYCPD 254 Query: 420 ELRSLLEGLLQRDVNRR 436 L ++ R Sbjct: 255 PLYEVMLKCWHPKAEMR 271 >4FL3-A nrPDB Length = 635 Score = 194 bits (494), Expect = 8e-50, Method: Composition-based stats. Identities = 54/264 (20%), Positives = 104/264 (39%), Gaps = 26/264 (9%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCR-----KADTGKMYAMKCLDKKRIKMKQGETLALNER 240 LT+ D + +G G FG V T + +K L Sbjct: 370 LTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKILK-------NEANDPALKDELL 418 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300 +++ D P+IV M + ++++ G L+ +L Q+ + ++ + Sbjct: 419 AEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQ 477 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG----- 355 + +G++++ V+RDL N+LL + +ISD GL+ + + THG Sbjct: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELP 414 + APE + + S +D +S G ++++ G P+R K + + + + P Sbjct: 538 WYAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM--LEKGERMGCP 594 Query: 415 DSFSPELRSLLEGLLQRDVNRRLG 438 E+ L+ DV R G Sbjct: 595 AGCPREMYDLMNLCWTYDVENRPG 618 >3RP9-A nrPDB Length = 458 Score = 194 bits (494), Expect = 9e-50, Method: Composition-based stats. Identities = 68/423 (16%), Positives = 139/423 (32%), Gaps = 115/423 (27%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + + +IG G +G V ++ A+K + +++ + +++++ Sbjct: 53 DRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKI----LRVFEDLIDCKRILREIAILNR 108 Query: 249 GDCPFIVCMSYAF-----HTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 + +V + D+L +L++ + D +E ++ +++ Sbjct: 109 LNHDHVVKVLDIVIPKDVEKFDELYVVLEIAD-SDFKKLFRTPVYLTELHIKTLLYNLLV 167 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-------------------- 343 G++++H+ +++RDLKPAN L+++ V++ D GLA Sbjct: 168 GVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNL 227 Query: 344 ---------KKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-------- 386 K++ V T Y APE++ Y + D +S+GC+ +LL Sbjct: 228 VTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAY 287 Query: 387 ---GHSPFRQ--------------------HKTKDKHEIDRMTLTMAVE----------- 412 F +D+ + L E Sbjct: 288 HADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDA 347 Query: 413 ------------------LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 P S S + LL+ +L + N+R+ E PFF+ Sbjct: 348 KRYIRIFPKREGTDLAERFPAS-SADAIHLLKRMLVFNPNKRITIN-----ECLAHPFFK 401 Query: 455 SL---DWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL 511 + + + +K P N D K I+ + +L R P Sbjct: 402 EVRIAEVETNATEKVRLPF-------NDWMNMDEPQLRYAFVKEIQRYHPEIQLPRRSPN 454 Query: 512 TIS 514 S Sbjct: 455 RAS 457 >6EII-A nrPDB Length = 352 Score = 194 bits (493), Expect = 1e-49, Method: Composition-based stats. Identities = 74/327 (22%), Positives = 132/327 (40%), Gaps = 63/327 (19%) Query: 169 DKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIK 228 D + +W N +D+ + R +GRG + EV+ + +K Sbjct: 48 DYESHVVEWGN--------QDDYQLVRKLGRGKYSEVFEAINITNNEK--------VVVK 91 Query: 229 MKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHLSQH 286 + + +R + L + P I+ ++ P + + + +N D + Sbjct: 92 ILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---Y 148 Query: 287 GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKK 345 ++ D+RFY EI+ L++ H+ +++RD+KP N+++D EH +R+ D GLA + Sbjct: 149 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG 208 Query: 346 KPH-ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR-QHKTKDK---- 399 + + V + + PE+L YD S D +SLGCML ++ PF H D+ Sbjct: 209 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 268 Query: 400 ----------HEIDRMTLTMAVELPDS--------------------FSPELRSLLEGLL 429 ID+ + + D SPE L+ LL Sbjct: 269 AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLL 328 Query: 430 QRDVNRRLGCLGRGAQEVKESPFFRSL 456 + D RL A+E E P+F ++ Sbjct: 329 RYDHQSRL-----TAREAMEHPYFYTV 350 >5ZTN-A nrPDB Length = 429 Score = 193 bits (491), Expect = 2e-49, Method: Composition-based stats. Identities = 66/326 (20%), Positives = 123/326 (37%), Gaps = 71/326 (21%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL-DKKRIKMKQGETLALNERIMLSLVST 248 + V ++IG+G FG+V + A+K + ++KR + E + + E L Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILE--HLRKQDK 155 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADMRFYAAEIILGLE 306 + ++ M F + + +L++ +L+ + ++ FS +R +A I+ L+ Sbjct: 156 DNTMNVIHMLENFTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLVRKFAHSILQCLD 214 Query: 307 HMHNRFVVYRDLKPANILLDEHGH--VRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 364 +H +++ DLKP NILL + G +++ D G +C + ++ + + + Y APEV+ Sbjct: 215 ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSC-YEHQRVYTYIQSRFYRAPEVIL- 272 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE------------ 412 G Y D +SLGC+L +LL G+ D+ L M + Sbjct: 273 GARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNF 332 Query: 413 -----LPDSF------------------------SPELR---------------SLLEGL 428 P PE R L+ Sbjct: 333 VSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQC 392 Query: 429 LQRDVNRRLGCLGRGAQEVKESPFFR 454 L+ D R+ + P+ R Sbjct: 393 LEWDPAVRMTPG-----QALRHPWLR 413 >4TPT-A nrPDB Length = 303 Score = 193 bits (490), Expect = 3e-49, Method: Composition-based stats. Identities = 57/271 (21%), Positives = 104/271 (38%), Gaps = 33/271 (12%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 D ++G+G FG+ TGK+ MK L + E + ++ + Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRC------DEETQKTFLTEVKVMRSL 54 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 D P ++ + KL+ + + + GG L L F +A I G+ ++H Sbjct: 55 DHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLH 114 Query: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDF----------------------SKKKP 347 + +++RDL N L+ V ++D GL+ +KK Sbjct: 115 SMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKR 174 Query: 348 HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTL 407 + VG +MAPE+L G +YD + D FS G +L +++ G + + + + Sbjct: 175 YTVVGNPYWMAPEMLN-GKSYDETVDIFSFGIVLCEII-GQV-YADPDCLPRTLDFGLNV 231 Query: 408 TMAVE--LPDSFSPELRSLLEGLLQRDVNRR 436 + E +P P L + + R Sbjct: 232 KLFWEKFVPTDCPPAFFPLAAICCRLEPESR 262 >4NEU-A nrPDB Length = 333 Score = 193 bits (490), Expect = 3e-49, Method: Composition-based stats. Identities = 65/277 (23%), Positives = 112/277 (40%), Gaps = 25/277 (9%) Query: 184 IHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML 243 I + +DF + GGFG+V C G M MK + K ++ E L ++M Sbjct: 19 IKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMN 77 Query: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 L +V + K S +++ M G+L + L + EII Sbjct: 78 RL----RHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIE 133 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS---------------KKKPH 348 G+ ++H + V+++DLKP NIL+D H++I+DLGLA Sbjct: 134 GMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAK 193 Query: 349 ASVGTHGYMAPEVLQK-GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTL 407 + GT YMAPE L +D +S +L+ + P+ ++ ++ I + Sbjct: 194 KNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPY-ENAICEQQLIMCIKS 252 Query: 408 TMAVELPD---SFSPELRSLLEGLLQRDVNRRLGCLG 441 ++ D E+ SL++ + + R G Sbjct: 253 GNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPG 289 >5XVU-A nrPDB Length = 332 Score = 192 bits (489), Expect = 4e-49, Method: Composition-based stats. Identities = 72/337 (21%), Positives = 137/337 (40%), Gaps = 58/337 (17%) Query: 160 DVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAM 219 F + K + + N+EL + N + + + IGRG + EV+ + + A Sbjct: 3 PKFYADVNIHKPKEYYDYDNLELQWN-KPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA- 60 Query: 220 KCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTP--DKLSFILDLMNGG 277 IK+ + +R + L + P I+ + P S I + +N Sbjct: 61 -------IKVLKPVKKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINNI 113 Query: 278 DLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDL 336 D + F++ D+R+Y +I+ L++ H++ +++RD+KP NI++D E+ +R+ Sbjct: 114 DFKTL---YPKFTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISW 170 Query: 337 GLACDFSKKKPH-ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHK 395 GLA + + + V + Y PE+L YD S D +SLGCML ++ PF Sbjct: 171 GLAEFYHPGQEYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFF-CG 229 Query: 396 TKDKHEIDRMTLTMAVEL-------------PDSFS-----------------------P 419 + ++ ++ + E P + Sbjct: 230 HDNYDQLVKIAKVLGTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKD 289 Query: 420 ELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 E+ L++ +L D +R+ +E E P+FR + Sbjct: 290 EVIDLIDKMLIYDHAKRI-----APKEAMEHPYFREV 321 >6HMD-A nrPDB Length = 365 Score = 192 bits (488), Expect = 4e-49, Method: Composition-based stats. Identities = 70/332 (21%), Positives = 134/332 (40%), Gaps = 65/332 (19%) Query: 169 DKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIK 228 D W N +D+ + R +GRG + EV+ + + +K Sbjct: 41 DYEAHVPSWGN--------QDDYQLVRKLGRGKYSEVFEAINITNNE--------RVVVK 84 Query: 229 MKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHLSQH 286 + + +R + L + I+ + P + + + +N D + Sbjct: 85 ILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL---Y 141 Query: 287 GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEH-GHVRISDLGLACDFSK- 344 + ++ D+RFY E++ L++ H++ +++RD+KP N+++D +R+ D GLA + Sbjct: 142 QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA 201 Query: 345 KKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDR 404 ++ + V + + PE+L YD S D +SLGCML ++ PF H + ++ R Sbjct: 202 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFF-HGQDNYDQLVR 260 Query: 405 MTLTMAVE---------------------------LPDSF---------SPELRSLLEGL 428 + + E ++F SPE LL+ L Sbjct: 261 IAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKL 320 Query: 429 LQRDVNRRLGCLGRGAQEVKESPFFRSLDWQM 460 L+ D +RL A+E E P+F + + Sbjct: 321 LRYDHQQRL-----TAKEAMEHPYFYPVVKEQ 347 >3EB0-A nrPDB Length = 383 Score = 192 bits (488), Expect = 4e-49, Method: Composition-based stats. Identities = 63/336 (18%), Positives = 119/336 (35%), Gaps = 86/336 (25%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMK-CLDKKRIKMKQGETLALNERIMLSLVSTG 249 +S+ + +G G FG V ++GK +A+K L R K ++ L ++ Sbjct: 9 YSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNRE-----------LDIMKVL 57 Query: 250 DCPFIVCMSYAFHT--------------------------------------PDKLSFIL 271 D I+ + F+T L+ I+ Sbjct: 58 DHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIM 117 Query: 272 DLMN---GGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD-E 327 + + L + + Y ++ + +H+ + +RD+KP N+L++ + Sbjct: 118 EYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSK 177 Query: 328 HGHVRISDLGLACDFSKKKPH-ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR 386 +++ D G A +P A + + Y APE++ Y S D +S+GC+ +L+ Sbjct: 178 DNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELIL 237 Query: 387 GHSPFRQHKTKDKH-EIDRMTLTMAVE-------------------------LPDSFSPE 420 G F + D+ I ++ T E LP+ Sbjct: 238 GKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSL 297 Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 LLE +L+ + + R+ E PFF L Sbjct: 298 AIDLLEQILRYEPDLRINPY-----EAMAHPFFDHL 328 >5C26-A nrPDB Length = 299 Score = 192 bits (488), Expect = 4e-49, Method: Composition-based stats. Identities = 54/264 (20%), Positives = 104/264 (39%), Gaps = 26/264 (9%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCR-----KADTGKMYAMKCLDKKRIKMKQGETLALNER 240 LT+ D + +G G FG V T + +K L Sbjct: 28 LTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKILK-------NEANDPALKDELL 76 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300 +++ D P+IV M + ++++ G L+ +L Q+ + ++ + Sbjct: 77 AEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQ 135 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG----- 355 + +G++++ V+RDL N+LL + +ISD GL+ + + THG Sbjct: 136 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 195 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELP 414 + APE + + S +D +S G ++++ G P+R K + + + + P Sbjct: 196 WYAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM--LEKGERMGCP 252 Query: 415 DSFSPELRSLLEGLLQRDVNRRLG 438 E+ L+ DV R G Sbjct: 253 AGCPREMYDLMNLCWTYDVENRPG 276 >2PVN-A nrPDB Length = 352 Score = 192 bits (487), Expect = 6e-49, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 124/320 (38%), Gaps = 56/320 (17%) Query: 177 WKNVELNIHLT-MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL 235 W L + +D+ V R +GRG + EV+ + + K IK+ + Sbjct: 39 WDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNE--------KCIIKILKPVKK 90 Query: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHT--PDKLSFILDLMNGGDLHYHLSQHGVFSEAD 293 +R + L + P IV + S I + +N D + ++ D Sbjct: 91 KKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVL---YPTLTDYD 147 Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEH-GHVRISDLGLACDFSKKKPH-ASV 351 +R+Y E++ L++ H++ +++RD+KP N+++D +R+ D GLA + K + V Sbjct: 148 IRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRV 207 Query: 352 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSP-FRQHKTKDKHEIDRMTLT-- 408 + + PE+L YD S D +SLGCM ++ P F H D+ L Sbjct: 208 ASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTD 267 Query: 409 --------MAVELPDS------------------------FSPELRSLLEGLLQRDVNRR 436 +EL SPE L+ LL+ D R Sbjct: 268 GLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQER 327 Query: 437 LGCLGRGAQEVKESPFFRSL 456 L L E P+F+ + Sbjct: 328 LTAL-----EAMTHPYFQQV 342 >5VD3-A nrPDB Length = 311 Score = 191 bits (486), Expect = 6e-49, Method: Composition-based stats. Identities = 73/265 (27%), Positives = 114/265 (43%), Gaps = 16/265 (6%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIML-SLVSTG 249 F +G G +GEV+ R + G++YA+K + + +G + + S G Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVK----RSMSPFRGPKDRARKLAEVGSHEKVG 114 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEHM 308 P V + A+ L +L G L H G EA + Y + +L L H+ Sbjct: 115 QHPCCVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHL 173 Query: 309 HNRFVVYRDLKPANILLDEHGHVRISDLGLACDF-SKKKPHASVGTHGYMAPEVLQKGVA 367 H++ +V+ D+KPANI L G ++ D GL + + G YMAPE+LQ Sbjct: 174 HSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS-- 231 Query: 368 YDSSADWFSLGCMLFKLLRG-HSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLE 426 Y ++AD FSLG + ++ P H + ++ + L E S ELRS+L Sbjct: 232 YGTAADVFSLGLTILEVACNMELP---HGGEGWQQLRQGYLP--PEFTAGLSSELRSVLV 286 Query: 427 GLLQRDVNRRLGCLGRGAQEVKESP 451 +L+ D R A V P Sbjct: 287 MMLEPDPKLRATAEALLALPVLRQP 311 >3C1X-A nrPDB Length = 373 Score = 191 bits (486), Expect = 8e-49, Method: Composition-based stats. Identities = 62/257 (24%), Positives = 107/257 (41%), Gaps = 22/257 (8%) Query: 193 VHRIIGRGGFGEVYGCRKAD-TGKM--YAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + +IGRG FG VY D GK A+K L+ RI + L E I++ S Sbjct: 93 FNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN--RITDIGEVSQFLTEGIIMKDFS-- 148 Query: 250 DCPFIVCMSY-AFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEH 307 P ++ + + +L M GDL + + D+ + ++ G++ Sbjct: 149 -HPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKF 207 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK---PHASVGTH---GYMAPEV 361 + ++ V+RDL N +LDE V+++D GLA D K+ H G +MA E Sbjct: 208 LASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALES 267 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD-KHEIDRMTLTMAVELPDSFSP 419 LQ + + +D +S G +L++L+ G P+ T D + + + P+ Sbjct: 268 LQT-QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQ---PEYCPD 323 Query: 420 ELRSLLEGLLQRDVNRR 436 L ++ R Sbjct: 324 PLYEVMLKCWHPKAEMR 340 >4G3E-A nrPDB Length = 352 Score = 191 bits (485), Expect = 9e-49, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 122/302 (40%), Gaps = 37/302 (12%) Query: 176 QWKNVELNIHLTMNDFSVHRII---------GRGGFGEVYGCRKADTGKMYAMKCLDKKR 226 + V L L D+ + GRG FGEV+ + TG A+K + + Sbjct: 52 DNEGVLLTEKLKPVDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEV 111 Query: 227 IKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH 286 ++++ A P IV + A ++ ++L+ GG L + Q Sbjct: 112 FRVEELVACA-----------GLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQM 160 Query: 287 GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHG-HVRISDLGLACDFSKK 345 G E +Y + + GLE++H R +++ D+K N+LL G + D G A Sbjct: 161 GCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPD 220 Query: 346 KPHASV-------GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 S+ GT +MAPEV+ G D+ D +S CM+ +L G P+ Q+ Sbjct: 221 GLGKSLLTGDYIPGTETHMAPEVVM-GKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGP 279 Query: 399 KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCL------GRGAQEV--KES 450 E+P S +P ++ L+++ R + G+ QEV +S Sbjct: 280 LCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRKVGKALQEVGGLKS 339 Query: 451 PF 452 P+ Sbjct: 340 PW 341 >5U6B-A nrPDB Length = 307 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 53/293 (18%), Positives = 108/293 (36%), Gaps = 31/293 (10%) Query: 176 QWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTG--KMYAMKCLDKKRIKMKQGE 233 + K ++ + + ++ + +G G FG V + A+K + + E Sbjct: 10 ELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELE 69 Query: 234 TLALNERIMLSLVSTGDCPFIVCMSYAF------HTPDKLSFILDLMNGGDLHYHL---- 283 M D P ++ + + IL M GDLH L Sbjct: 70 DFLSEAVCMKE----FDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSR 125 Query: 284 --SQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD 341 Q + + A+I G+E++ + ++RDL N +L+E+ V ++D GL+ Sbjct: 126 LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKK 185 Query: 342 FSKKKPHASVGTH----GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKT 396 + ++A E L V Y S +D +S G ++++ G +P+ + Sbjct: 186 IYNGDYYRQGRIAKMPVKWIAIESLADRV-YTSKSDVWSFGVTMWEIATRGQTPYPGVEN 244 Query: 397 KDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKE 449 + ++ R ++ P L +L+ + + R E++E Sbjct: 245 SEIYDYLR--QGNRLKQPADCLDGLYALMSRCWELNPQDR-----PSFTELRE 290 >6CTH-A nrPDB Length = 309 Score = 188 bits (478), Expect = 6e-48, Method: Composition-based stats. Identities = 63/284 (22%), Positives = 112/284 (39%), Gaps = 33/284 (11%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 ++F+ +G GGFG VY D+ A+K + + KQG +E ++S + Sbjct: 15 SNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSR---ASKQGIKEYASEVKIISRLR- 70 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRF-YAAEIILGLEH 307 +V + H +L + + M G L H+ + ++R+ ++ L + Sbjct: 71 --HKNLVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLY 128 Query: 308 MHNRF---VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP---HASVGTHGYMAPEV 361 +H V++RD+K +NI+LD + ++ D GLA K GT GYMAPE Sbjct: 129 LHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPEC 188 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHS---------------PFRQHKTKDKHEIDRMT 406 L G A +D +S G + ++ G P+ ++ +D Sbjct: 189 LSSGKA-SKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIAD 247 Query: 407 LTMAVELPDSFSPELRSL-LEGLLQRDVNRRLGCLGRGAQEVKE 449 + + +L L + GL + L R +V Sbjct: 248 RKLGMAFDPK---QLECLVMVGLWCAHPSHNLRPSIRQVIQVLN 288 >4C59-A nrPDB Length = 340 Score = 188 bits (478), Expect = 6e-48, Method: Composition-based stats. Identities = 56/278 (20%), Positives = 103/278 (37%), Gaps = 38/278 (13%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 V R++ GGF VY + +G+ YA+K L ++ + E + +S Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRL---LSNEEEKNRAIIQEVCFMKKLS-- 82 Query: 250 DCPFIVCM--------SYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAA 299 P IV + + + +L G + + G S + Sbjct: 83 GHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFY 142 Query: 300 EIILGLEHMHNRF--VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG----- 352 + ++HMH + +++RDLK N+LL G +++ D G A S ++ Sbjct: 143 QTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRAL 202 Query: 353 ---------THGYMAPEVLQKGVAY--DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE 401 T Y PE++ + D ++LGC+L+ L PF D + Sbjct: 203 VEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFE-----DGAK 257 Query: 402 IDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGC 439 + + ++ D+ SL+ +LQ + RL Sbjct: 258 LRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSI 295 >5X8I-B nrPDB Length = 346 Score = 187 bits (476), Expect = 1e-47, Method: Composition-based stats. Identities = 61/329 (18%), Positives = 114/329 (34%), Gaps = 76/329 (23%) Query: 190 DFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKCLDK--KRIKMKQGETLALNERIMLSLV 246 + + +G G FG+V C G+ A+K + + + + E L Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPN 73 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAEIILG 304 ST C V M F + + +L+ G + + ++G F +R A +I Sbjct: 74 STFRC---VQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMAYQICKS 129 Query: 305 LEHMHNRFVVYRDLKPANILLDE-------------------HGHVRISDLGLACDFSKK 345 + +H+ + + DLKP NIL + + +++ D G A + + Sbjct: 130 VNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSAT-YDDE 188 Query: 346 KPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRM 405 V T Y APEV+ + + D +S+GC+L + G + F H +K+ + Sbjct: 189 HHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMER 247 Query: 406 TLTMAVELP------------------------DSFSPELR-----------------SL 424 L + S + L Sbjct: 248 ILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDL 307 Query: 425 LEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 ++ +L+ D +R+ +E + PFF Sbjct: 308 IQKMLEYDPAKRITL-----REALKHPFF 331 >4M7I-A nrPDB Length = 299 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 114/300 (38%), Gaps = 44/300 (14%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + DF + +GRGGFG V+ + YA+K RI++ E + ++ Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIK-----RIRLPNRELAREKVMREVKALA 58 Query: 248 TGDCPFIVCMSYAFHTPD------------KLSFILDLMNGGDLHYHLSQHGVFSEAD-- 293 + P IV A+ + L + L +L ++ E + Sbjct: 59 KLEHPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERS 118 Query: 294 -MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP----- 347 +I +E +H++ +++RDLKP+NI V++ D GL + + Sbjct: 119 VCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVL 178 Query: 348 ---------HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD 398 VGT YM+PE + G +Y D FSLG +LF+LL PF + Sbjct: 179 TPMPAYARHTGQVGTKLYMSPEQIH-GNSYSHKVDIFSLGLILFELL---YPFSTQMERV 234 Query: 399 KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDW 458 + D L + E +++ +L R A + E+ F LD+ Sbjct: 235 RTLTDVRNLKFPPLFTQKYPCE-YVMVQDMLSPSPMER-----PEAINIIENAVFEDLDF 288 >3UIM-A nrPDB Length = 326 Score = 186 bits (473), Expect = 3e-47, Method: Composition-based stats. Identities = 70/237 (29%), Positives = 105/237 (44%), Gaps = 18/237 (7%) Query: 167 ESDKFTRFCQWKNVEL-NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK 225 E D Q K L + + ++FS I+GRGGFG+VY R AD G + A+K L ++ Sbjct: 7 EEDPEVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGRLAD-GTLVAVKRLKEE 65 Query: 226 RIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ 285 R + GE E M+S+ ++ + TP + + M G + L + Sbjct: 66 RT--QGGELQFQTEVEMISMAV---HRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRE 120 Query: 286 HG----VFSEADMRFYAAEIILGLEHMHNR---FVVYRDLKPANILLDEHGHVRISDLGL 338 + A GL ++H+ +++RD+K ANILLDE + D GL Sbjct: 121 RPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGL 180 Query: 339 ACDFSKKKPHASV---GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR 392 A K H + GT G++APE L G + D F G ML +L+ G F Sbjct: 181 AKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKS-SEKTDVFGYGVMLLELITGQRAFD 236 >4KIK-B nrPDB Length = 677 Score = 186 bits (472), Expect = 3e-47, Method: Composition-based stats. Identities = 68/280 (24%), Positives = 120/280 (42%), Gaps = 40/280 (14%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + +G GGFG V +TG+ A+K ++ + + E L +IM L Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQ-CRQELSPRNRERWCLEIQIMRRLT---- 75 Query: 251 CPFIVCMSYAFHTPDKLS------FILDLMNGGDLHYHLSQHGV---FSEADMRFYAAEI 301 P +V L+ ++ GGDL +L+Q E + ++I Sbjct: 76 HPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDI 135 Query: 302 ILGLEHMHNRFVVYRDLKPANILL---DEHGHVRISDLGLACDFSKKKP-HASVGTHGYM 357 L ++H +++RDLKP NI+L ++ +I DLG A + + + VGT Y+ Sbjct: 136 ASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYL 195 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF--------RQHKTKDKHEID------ 403 APE+L++ Y + D++S G + F+ + G PF K + K E+D Sbjct: 196 APELLEQ-QKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSED 254 Query: 404 ---RMTLTMAVELPDSFSPELRSLLEGLLQR----DVNRR 436 + + ++ P++ + L LE LQ +R Sbjct: 255 LNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQR 294 >5LPZ-A nrPDB Length = 332 Score = 186 bits (472), Expect = 3e-47, Method: Composition-based stats. Identities = 68/257 (26%), Positives = 105/257 (40%), Gaps = 26/257 (10%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 N F +IG GGFG+VY D G A+K L QG+ + E + + Sbjct: 17 NGFHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIH---VSGQGDREFMAE---METIGK 69 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV----FSEADMRFYAAEIILG 304 +V + D+ + + M G L L + + R A G Sbjct: 70 IKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARG 129 Query: 305 LEHMH---NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV----GTHGYM 357 L +H + +++RD+K +N+LLDE+ R+SD G+A S H SV GT GY+ Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSF 417 PE Q + D +S G +L +LL G P D + + + + + D F Sbjct: 190 PPEYYQ-SFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVF 248 Query: 418 SPELRSLLEGLLQRDVN 434 PE L++ D Sbjct: 249 DPE-------LMKEDPA 258 >5LPV-A nrPDB Length = 296 Score = 185 bits (471), Expect = 4e-47, Method: Composition-based stats. Identities = 68/257 (26%), Positives = 105/257 (40%), Gaps = 26/257 (10%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 N F +IG GGFG+VY D G A+K L QG+ + E + + Sbjct: 17 NGFHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIH---VSGQGDREFMAE---METIGK 69 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV----FSEADMRFYAAEIILG 304 +V + D+ + + M G L L + + R A G Sbjct: 70 IKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARG 129 Query: 305 LEHMH---NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV----GTHGYM 357 L +H + +++RD+K +N+LLDE+ R+SD G+A S H SV GT GY+ Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSF 417 PE Q + D +S G +L +LL G P D + + + + + D F Sbjct: 190 PPEYYQ-SFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVF 248 Query: 418 SPELRSLLEGLLQRDVN 434 PE L++ D Sbjct: 249 DPE-------LMKEDPA 258 >6B2Q-A nrPDB Length = 317 Score = 185 bits (470), Expect = 5e-47, Method: Composition-based stats. Identities = 62/278 (22%), Positives = 110/278 (39%), Gaps = 15/278 (5%) Query: 179 NVELNIHLTMN-DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLAL 237 ++ + +T++ + + R+I GG G+V+ G+ A+K L + + Sbjct: 21 HMSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPE---FIE 77 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFH-----TPDKLSFILDLMNGGDLHYHLSQHGVFSEA 292 R + + P I + +++L+NG L+ L + G S Sbjct: 78 RFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLR 137 Query: 293 DMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK---KKPHA 349 + L+ H +V+RD+KP NIL+ G V+I+D G+A + Sbjct: 138 HALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGM 197 Query: 350 SVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTM 409 +GT Y+APE A ++D +SLG + ++ + G PF + Sbjct: 198 VMGTAQYIAPEQALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVA--MKHIKEP 254 Query: 410 AVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEV 447 LP P +R L+E L ++ R G A V Sbjct: 255 PPPLPPDLPPNVRELIEITLVKNPAMRYRSGGPFADAV 292 >2WO6-A nrPDB Length = 382 Score = 185 bits (470), Expect = 5e-47, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 111/250 (44%), Gaps = 16/250 (6%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 M+ + + +IG+G FG+V + A+K + K+ + Q + E +L L++ Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI----EVRLLELMN 108 Query: 248 TGDCP---FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS--QHGVFSEADMRFYAAEII 302 D +IV + F + L + ++++ +L+ L S R +A ++ Sbjct: 109 KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKFAQQMC 167 Query: 303 LGLEHMH--NRFVVYRDLKPANILL--DEHGHVRISDLGLACDFSKKKPHASVGTHGYMA 358 L + +++ DLKP NILL + ++I D G +C + + + + + Y + Sbjct: 168 TALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ-RIYQYIQSRFYRS 226 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS 418 PEVL G+ YD + D +SLGC+L ++ G F D+ L + + Sbjct: 227 PEVLL-GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQA 285 Query: 419 PELRSLLEGL 428 P+ R E L Sbjct: 286 PKARKFFEKL 295 Score = 35.0 bits (79), Expect = 0.12, Method: Composition-based stats. Identities = 6/34 (17%), Positives = 12/34 (35%), Gaps = 5/34 (14%) Query: 421 LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 + L+ +L D R+ + FF+ Sbjct: 349 FKDLILRMLDYDPKTRIQPYY-----ALQHSFFK 377 >4OW8-A nrPDB Length = 283 Score = 185 bits (470), Expect = 5e-47, Method: Composition-based stats. Identities = 61/266 (22%), Positives = 103/266 (38%), Gaps = 14/266 (5%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + + R+I GG G+V+ G+ A+K L + + R + Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPE---FIERFRAEARTTAML 68 Query: 250 DCPFIVCMSYAFH-----TPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 + P I + +++L+NG L+ L + G S + Sbjct: 69 NHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRA 128 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK---KKPHASVGTHGYMAPEV 361 L+ H +V+RD+KP NIL+ G V+I+D G+A + +GT Y+APE Sbjct: 129 LQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQ 188 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 A ++D +SLG + ++ + G PF + LP P + Sbjct: 189 ALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVA--MKHIKEPPPPLPPDLPPNV 245 Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQEV 447 R L+E L ++ R G A V Sbjct: 246 RELIEITLVKNPAMRYRSGGPFADAV 271 >3QA8-A nrPDB Length = 676 Score = 185 bits (470), Expect = 5e-47, Method: Composition-based stats. Identities = 61/214 (28%), Positives = 100/214 (46%), Gaps = 19/214 (8%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + +G GGFG V DTG+ A+K ++ + K E L +IM L + Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQ-CRQELSPKNRERWCLEIQIMKKL----N 70 Query: 251 CPFIVCMSYAFHTPDKLS------FILDLMNGGDLHYHLSQHGV---FSEADMRFYAAEI 301 P +V KL+ ++ GGDL +L+Q E +R ++I Sbjct: 71 HPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDI 130 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHV---RISDLGLACDFSKKKP-HASVGTHGYM 357 L ++H +++RDLKP NI+L +I DLG A + + + VGT Y+ Sbjct: 131 SSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYL 190 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 APE+L++ Y + D++S G + F+ + G PF Sbjct: 191 APELLEQ-KKYTVTVDYWSFGTLAFECITGFRPF 223 >4X3F-A nrPDB Length = 337 Score = 185 bits (470), Expect = 5e-47, Method: Composition-based stats. Identities = 61/266 (22%), Positives = 103/266 (38%), Gaps = 14/266 (5%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + + R+I GG G+V+ G+ A+K L + + R + Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPE---FIERFRAEARTTAML 69 Query: 250 DCPFIVCMSYAFH-----TPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 + P I + +++L+NG L+ L + G S + Sbjct: 70 NHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRA 129 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK---KKPHASVGTHGYMAPEV 361 L+ H +V+RD+KP NIL+ G V+I+D G+A + +GT Y+APE Sbjct: 130 LQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQ 189 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 A ++D +SLG + ++ + G PF + LP P + Sbjct: 190 ALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVA--MKHIKEPPPPLPPDLPPNV 246 Query: 422 RSLLEGLLQRDVNRRLGCLGRGAQEV 447 R L+E L ++ R G A V Sbjct: 247 RELIEITLVKNPAMRYRSGGPFADAV 272 >5VC6-A nrPDB Length = 289 Score = 183 bits (465), Expect = 2e-46, Method: Composition-based stats. Identities = 70/275 (25%), Positives = 114/275 (41%), Gaps = 33/275 (12%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +F IG G FG V+ C K G +YA+K KK + E AL E +++ Sbjct: 11 TEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKR-SKKPLAGSVDEQNALREVYAHAVL-- 67 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV----FSEADMRFYAAEIILG 304 G +V A+ D + + NGG L +S++ F EA+++ ++ G Sbjct: 68 GQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRG 127 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHV-------------------RISDLGLACDFSKK 345 L ++H+ +V+ D+KP+NI + +I DLG S Sbjct: 128 LRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISS- 186 Query: 346 KPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRM 405 P G ++A EVLQ+ + AD F+L + G P ++ + HEI + Sbjct: 187 -PQVEEGDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLPRNGDQ-WHEIRQG 243 Query: 406 TLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCL 440 L +P S E LL+ ++ D RR + Sbjct: 244 RL---PRIPQVLSQEFTELLKVMIHPDPERRPSAM 275 >2A1A-B nrPDB Length = 284 Score = 182 bits (462), Expect = 4e-46, Method: Composition-based stats. Identities = 61/257 (23%), Positives = 106/257 (41%), Gaps = 19/257 (7%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 DF +IG GGFG+V+ + GK Y +K + K + E AL + +++V Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKA-EREVKALAKLDHVNIVHYN 70 Query: 250 DC-------PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAE 300 C P + + L ++ + G L + + + + Sbjct: 71 GCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQ 130 Query: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAP 359 I G++++H++ ++ RDLKP+NI L + V+I D GL K S GT YM+P Sbjct: 131 ITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSP 190 Query: 360 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSP 419 E + Y D ++LG +L +LL + + + D F Sbjct: 191 EQIS-SQDYGKEVDLYALGLILAELLH-----VCDTAFETSKFFTDLRDGI--ISDIFDK 242 Query: 420 ELRSLLEGLLQRDVNRR 436 + ++LL+ LL + R Sbjct: 243 KEKTLLQKLLSKKPEDR 259 >5U6C-A nrPDB Length = 315 Score = 182 bits (462), Expect = 5e-46, Method: Composition-based stats. Identities = 52/263 (19%), Positives = 101/263 (38%), Gaps = 26/263 (9%) Query: 193 VHRIIGRGGFGEVYGC---RKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + +I+G G FG V ++ T A+K + ++ E M Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM----KDF 95 Query: 250 DCPFIVCMSYAFHTPD-----KLSFILDLMNGGDLHYHL------SQHGVFSEADMRFYA 298 P ++ + K IL M GDLH +L + + + Sbjct: 96 SHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFM 155 Query: 299 AEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH---- 354 +I LG+E++ NR ++RDL N +L + V ++D GL+ + Sbjct: 156 VDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPV 215 Query: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVEL 413 ++A E L V Y S +D ++ G ++++ G +P+ + + + D + ++ Sbjct: 216 KWIAIESLADRV-YTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMY--DYLLHGHRLKQ 272 Query: 414 PDSFSPELRSLLEGLLQRDVNRR 436 P+ EL ++ + D R Sbjct: 273 PEDCLDELYEIMYSCWRTDPLDR 295 >4LFI-A nrPDB Length = 374 Score = 181 bits (460), Expect = 7e-46, Method: Composition-based stats. Identities = 65/362 (17%), Positives = 132/362 (36%), Gaps = 79/362 (21%) Query: 165 FIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAM----- 219 I + + ++N ++ D+ + +GRG + EV+ K D+ + Sbjct: 16 NINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP 75 Query: 220 -------------------KC------LDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 254 K K + Q E + R + I Sbjct: 76 VKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANI 135 Query: 255 VCMSYAFHTP--DKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF 312 + + P + + + ++ + ++ ++RFY E++ L++ H+ Sbjct: 136 IHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMG 192 Query: 313 VVYRDLKPANILLD-EHGHVRISDLGLACDFSKK-KPHASVGTHGYMAPEVLQKGVAYDS 370 +++RD+KP N+++D ++ +R+ D GLA + + + V + + PE+L YD Sbjct: 193 IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDY 252 Query: 371 SADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMT------------LTMAVELPDSF- 417 S D +S G ML ++ PF H T + ++ ++ L + LP F Sbjct: 253 SLDLWSFGTMLASMIFKREPFF-HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFY 311 Query: 418 -----------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454 + E+ L++ LL+ D RL A+E P+F Sbjct: 312 DMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFA 366 Query: 455 SL 456 + Sbjct: 367 PI 368 >5WNO-A nrPDB Length = 330 Score = 181 bits (459), Expect = 9e-46, Method: Composition-based stats. Identities = 50/258 (19%), Positives = 98/258 (37%), Gaps = 21/258 (8%) Query: 192 SVHRIIGRGGFGEVYGC-----RKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 + + +G G FG V+ R + A+K + + + A N + Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATN-------M 77 Query: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGL 305 ++ + D L + G+L L H + Y +I G+ Sbjct: 78 FRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGM 137 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGT----HGYMAPEV 361 +++ + VV+RDL N+L+ + HV I+D GL+ ++ + ++A E+ Sbjct: 138 QYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEI 197 Query: 362 LQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 K Y ++D ++ G ++++ G SP++ T H + + P + S + Sbjct: 198 FSKHC-YTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKD--GNRLSQPPNCSQD 254 Query: 421 LRSLLEGLLQRDVNRRLG 438 L L D R G Sbjct: 255 LYQELLRCWMADPKSRPG 272 >5TOS-A nrPDB Length = 395 Score = 181 bits (459), Expect = 9e-46, Method: Composition-based stats. Identities = 63/291 (21%), Positives = 109/291 (37%), Gaps = 41/291 (14%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCR---------KADTGKMYAMKCLDKKRIKMKQGE 233 + L +F +IG GGFG V+ K TG + A+K L+ ++G Sbjct: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN------QEGF 112 Query: 234 TLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG----VF 289 ++ + P +V + + + + M G L HL + G Sbjct: 113 QGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPL 172 Query: 290 SEADMRFYAAEIILGLEHMHN--RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 347 A + GL +H+ V+YRD+K +NILLD + ++SD GLA D Sbjct: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 Query: 348 ----HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI- 402 +GT+GY APE + G ++ +D +S G +L ++L G ++ + + Sbjct: 233 SYVSTRVMGTYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 Query: 403 ----------DRMTLTMAVELP-DSFSPELRSLLE---GLLQRDVNRRLGC 439 ++ L + L E + L + R Sbjct: 292 DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTM 342 >6FYV-A nrPDB Length = 337 Score = 181 bits (459), Expect = 1e-45, Method: Composition-based stats. Identities = 60/330 (18%), Positives = 116/330 (35%), Gaps = 78/330 (23%) Query: 190 DFSVHRIIGRGGFGEVYGCRKAD-TGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + + +G G FG+V C G A+K + + + A +E +L +++ Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVK----NVGRYREAARSEIQVLEHLNS 70 Query: 249 GDCPFI---VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAEIIL 303 D + V M F + + +L+ G + + ++ F +R A +I Sbjct: 71 TDPNSVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMAYQICQ 129 Query: 304 GLEHMHNRFVVYRDLKPANILLD-------------------EHGHVRISDLGLACDFSK 344 + +H+ + + DLKP NIL ++ +++ D G A + Sbjct: 130 SINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSAT-YDD 188 Query: 345 KKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDR 404 + V T Y APEV+ + + D +S+GC+L + G + F+ H +K+ + Sbjct: 189 EHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMME 247 Query: 405 MTLTMAVE-----------------------------------------LPDSFSPELRS 423 L + D +L Sbjct: 248 RILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFD 307 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 L+ +L+ D +R+ E + PFF Sbjct: 308 LVRRMLEYDPTQRITL-----DEALQHPFF 332 >5VDK-A nrPDB Length = 297 Score = 181 bits (459), Expect = 1e-45, Method: Composition-based stats. Identities = 71/277 (25%), Positives = 113/277 (40%), Gaps = 37/277 (13%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 +F IG G FG VY C K G +YA+K K E AL+E +++ G Sbjct: 16 EFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR-SMKTFTELSNENSALHEVYAHAVL--G 72 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH----GVFSEADMRFYAAEIILGL 305 P +V ++ D + + NGG L +S++ F E ++ +I LGL Sbjct: 73 HHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGL 132 Query: 306 EHMHNRFVVYRDLKPANI-----------------------LLDEHGHVRISDLGLACDF 342 ++HN +V+ D+KP+NI L + +I DLG A Sbjct: 133 NYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSI 192 Query: 343 SKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI 402 KP G ++A E+LQ+ + AD F+LG + + G + H I Sbjct: 193 --NKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIA-VAAGAESLPTNGAA-WHHI 248 Query: 403 DRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGC 439 + ++P S SLL+ ++Q D +R Sbjct: 249 RKGNF---PDVPQELSESFSSLLKNMIQPDAEQRPSA 282 >6J5U-C nrPDB Length = 426 Score = 181 bits (459), Expect = 1e-45, Method: Composition-based stats. Identities = 70/279 (25%), Positives = 106/279 (37%), Gaps = 39/279 (13%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADT---------GKMYAMKCLDKKRIKMKQGETLALNER 240 +F ++G GGFG V+ T G + A+K L + QG L E Sbjct: 85 NFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGF---QGHKEWLTEV 141 Query: 241 IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYA 298 L +S P +V + + + + M G L HL + G + A A Sbjct: 142 NYLGQLS---HPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVA 198 Query: 299 AEIILGLEHMHNRF--VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP----HASVG 352 GL +H V+YRD K ANILLD + ++SD GLA +G Sbjct: 199 VGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIG 258 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSP--------------FRQHKTKD 398 THGY APE + G + +D +S G +L +L+ G + D Sbjct: 259 THGYAAPEYVATGR-LTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLGD 317 Query: 399 KHEIDRMT-LTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 K ++ R+ + + P + +L L D R Sbjct: 318 KRKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLR 356 >3HNG-A nrPDB Length = 360 Score = 180 bits (458), Expect = 1e-45, Method: Composition-based stats. Identities = 68/333 (20%), Positives = 122/333 (36%), Gaps = 76/333 (22%) Query: 178 KNVELNIHLTMNDFSVHRIIGRGGFGEV-----YGCRKADTGKMYAMKCLDK-------- 224 + + +GRG FG+V +G +K+ T + A+K L + Sbjct: 16 PYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYK 75 Query: 225 ---KRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYA--------FHTPDKLSFI--- 270 +K+ LN +L + P +V + Y + L F+ Sbjct: 76 ALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKD 135 Query: 271 ----LD----LMNGG---------------------------DLHYHLSQ-------HGV 288 ++ M G L + Sbjct: 136 AALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEP 195 Query: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH 348 + D+ Y+ ++ G+E + +R ++RDL NILL E+ V+I D GLA D K + Sbjct: 196 ITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDY 255 Query: 349 ASVG-TH---GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEID 403 G T +MAPE + + Y + +D +S G +L+++ G SP+ + D+ Sbjct: 256 VRKGDTRLPLKWMAPESIFDKI-YSTKSDVWSYGVLLWEIFSLGGSPYPGVQ-MDEDFCS 313 Query: 404 RMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 R+ M + P+ +PE+ ++ RD R Sbjct: 314 RLREGMRMRAPEYSTPEIYQIMLDCWHRDPKER 346 >5WNL-A nrPDB Length = 342 Score = 180 bits (458), Expect = 1e-45, Method: Composition-based stats. Identities = 65/270 (24%), Positives = 110/270 (40%), Gaps = 22/270 (8%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 +F+ +G GGFG+VY R A+KC + + E + L E ++ Sbjct: 21 EFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKC--SPSLHVDDRERMELLEEAKKMEMAKF 78 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 +I+ + P + +++ M G L L+ E +G+ +H Sbjct: 79 R--YILPVYGICQEP--VGLVMEYMETGSLEKLLASE-PLPWDLRFRIVHETAVGMNFLH 133 Query: 310 --NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV-----GTHGYMAPEVL 362 + +++ +LKPANILLD H HV+ISD GLA H GT Y+ PE + Sbjct: 134 CMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERI 193 Query: 363 -QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPEL 421 +K +D+ D +S +++ +L PF K H + ++ ELP P Sbjct: 194 REKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNI-LHIMMKVVKGHRPELPPICRPRP 252 Query: 422 RS------LLEGLLQRDVNRRLGCLGRGAQ 445 R+ L++ D R ++ Sbjct: 253 RACASLIGLMQRCWHADPQVRPTFQEITSE 282 >5TQX-A nrPDB Length = 655 Score = 180 bits (456), Expect = 2e-45, Method: Composition-based stats. Identities = 70/301 (23%), Positives = 128/301 (42%), Gaps = 50/301 (16%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + +G GGFG V + + A+K + + K E +IM L + Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKS-CRLELSTKNRERWCHEIQIMKKL----N 64 Query: 251 CPFIVCMSYAFHTPDKLSFI--------LDLMNGGDLHYHLSQHGV---FSEADMRFYAA 299 +V A P++L+ + ++ +GGDL L++ E+ + + Sbjct: 65 HANVVK---ACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLS 121 Query: 300 EIILGLEHMHNRFVVYRDLKPANILL-DEHGHV--RISDLGLACDFSKKKP-HASVGTHG 355 +I G+ ++H +++RDLKP NI+L D G + +I DLG A D + + VGT Sbjct: 122 DIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQ 181 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQH-KTKDKHEIDRMT-------- 406 Y+APE L + Y ++ D++S G M+F+ + G+ PF H + HE + Sbjct: 182 YLAPE-LFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFAC 240 Query: 407 --LTMAVELPDSFSP--ELRSLL--------EGLLQRDVNRRLGCLGRGAQE-----VKE 449 ++ V L SL+ + +L D +R G + ++ + + Sbjct: 241 EEMSGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRCFVLMD 300 Query: 450 S 450 Sbjct: 301 H 301 >3LLT-A nrPDB Length = 360 Score = 179 bits (454), Expect = 4e-45, Method: Composition-based stats. Identities = 77/362 (21%), Positives = 127/362 (35%), Gaps = 89/362 (24%) Query: 165 FIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD- 223 F D+ F K + LN N F V R +G G FG V C+ D K YA+K + Sbjct: 16 FQGDDEIVHFSWKKGMLLN-----NAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRN 70 Query: 224 -KKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYH 282 KK + + E L + + + V F D + I + + G L+ Sbjct: 71 IKKYTRSAKIEADILKKIQNDDINNNNI----VKYHGKFMYYDHMCLIFEPL-GPSLYEI 125 Query: 283 LSQHGV--FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDE------------- 327 ++++ F D++ Y EI+ L ++ + + DLKP NILLD+ Sbjct: 126 ITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRV 185 Query: 328 ------------HGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWF 375 +++ D G A F + + T Y APEV+ + +D S+D + Sbjct: 186 TDGKKIQIYRTKSTGIKLIDFGCAT-FKSDYHGSIINTRQYRAPEVIL-NLGWDVSSDMW 243 Query: 376 SLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTL-----------------------TMAVE 412 S GC+L +L G FR H+ + + + + + Sbjct: 244 SFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLA 303 Query: 413 LPDSFS--------------------PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPF 452 P++ S L +LQ D R E+ + F Sbjct: 304 WPENASSINSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLR-----PSPAELLKHKF 358 Query: 453 FR 454 Sbjct: 359 LE 360 >5UIU-A nrPDB Length = 323 Score = 178 bits (451), Expect = 9e-45, Method: Composition-based stats. Identities = 66/275 (24%), Positives = 101/275 (36%), Gaps = 27/275 (9%) Query: 194 HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPF 253 +G GGFG VY +T A+K L + E L + +++ Sbjct: 52 GNKMGEGGFGVVYKGYVNNT--TVAVKKL--AAMVDITTEELKQQFDQEIKVMAKCQHEN 107 Query: 254 IVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ---HGVFSEADMRFYAAEIILGLEHMHN 310 +V + D L + M G L LS S A G+ +H Sbjct: 108 LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 167 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS----VGTHGYMAPEVLQKGV 366 ++RD+K ANILLDE +ISD GLA K VGT YMAPE L+ + Sbjct: 168 NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI 227 Query: 367 AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTM-----------AVELPD 415 +D +S G +L +++ G +H+ + + + D Sbjct: 228 --TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD 285 Query: 416 SFSPEL-RSLLEGLLQRDVNRRLGCLGRGAQEVKE 449 S S E S+ L N+R Q++ + Sbjct: 286 STSVEAMYSVASQCLHEKKNKRPDIKK--VQQLLQ 318 >3Q4U-A nrPDB Length = 301 Score = 178 bits (451), Expect = 9e-45, Method: Composition-based stats. Identities = 71/289 (24%), Positives = 116/289 (40%), Gaps = 44/289 (15%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 D ++ +G+G +GEV+ G+ A+K + K ET N + L Sbjct: 9 DITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRETELYNTVM---LRHEN 63 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 FI + H+ +L I G L+ +L + + + +R I GL H+H Sbjct: 64 ILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLR-IVLSIASGLAHLH 122 Query: 310 --------NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK------KPHASVGTHG 355 + +RDLK NIL+ ++G I+DLGLA S+ + VGT Sbjct: 123 IEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKR 182 Query: 356 YMAPEVLQKGVAYD-----SSADWFSLGCMLFKLLRG----------HSPFRQHKTKDKH 400 YMAPEVL + + D D ++ G +L+++ R PF D Sbjct: 183 YMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPS 242 Query: 401 -EIDRMTLTMAVELPD----SFS----PELRSLLEGLLQRDVNRRLGCL 440 E R + + + P+ FS L L++ ++ + RL L Sbjct: 243 FEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTAL 291 >5UNP-A nrPDB Length = 369 Score = 177 bits (450), Expect = 1e-44, Method: Composition-based stats. Identities = 67/354 (18%), Positives = 116/354 (32%), Gaps = 77/354 (21%) Query: 163 QKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCR-KADTGKMYAMKC 221 K +E D L + + +G G FG V C G A+K Sbjct: 13 AKSVEDDAEGHLIYHVGDWLQ-----ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKI 67 Query: 222 LDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHY 281 + K K K+ L +N ++ + V M F + +L+ G Sbjct: 68 I-KNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFD 125 Query: 282 HLSQHG--VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL-------------- 325 L + + +R A ++ ++ +H+ + + DLKP NIL Sbjct: 126 FLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKK 185 Query: 326 -----DEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCM 380 + VR+ D G A F + V T Y APEV+ + + + D +S+GC+ Sbjct: 186 RDERSVKSTAVRVVDFGSAT-FDHEHHSTIVSTRHYRAPEVILE-LGWSQPCDVWSIGCI 243 Query: 381 LFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV----------------------------- 411 +F+ G + F+ H ++ + L Sbjct: 244 IFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY 303 Query: 412 ------ELPDSFSPELR------SLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 L + E L+E +L+ + +RL E + PFF Sbjct: 304 VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLG-----EALQHPFF 352 >3UIU-A nrPDB Length = 306 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 57/279 (20%), Positives = 104/279 (37%), Gaps = 50/279 (17%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 DF +IG GGFG+V+ + GK Y ++ + K ++ + ++ Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAER----------EVKALAKL 62 Query: 250 DCPFIVCMSYAFH-----------------------------TPDKLSFILDLMNGGDLH 280 D IV + + L ++ + G L Sbjct: 63 DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLE 122 Query: 281 YHLSQHG--VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGL 338 + + + +I G++++H++ +++RDLKP+NI L + V+I D GL Sbjct: 123 QWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGL 182 Query: 339 ACDFS-KKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK 397 K S GT YM+PE + Y D ++LG +L +LL Sbjct: 183 VTSLKNDGKRTRSKGTLRYMSPEQIS-SQDYGKEVDLYALGLILAELLH-----VCDTAF 236 Query: 398 DKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 + + + D F + ++LL+ LL + R Sbjct: 237 ETSKFFTDLRDGI--ISDIFDKKEKTLLQKLLSKKPEDR 273 >3LMG-A nrPDB Length = 344 Score = 177 bits (448), Expect = 2e-44, Method: Composition-based stats. Identities = 51/268 (19%), Positives = 104/268 (38%), Gaps = 13/268 (4%) Query: 176 QWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKC-LDKKRIKMKQGET 234 + N L + +++G G FG V+ G+ +K + K I+ K G Sbjct: 18 EKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGES--IKIPVCIKVIEDKSGRQ 75 Query: 235 LALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH-GVFSEAD 293 + + + D IV + L + + G L H+ QH G Sbjct: 76 SFQAVTDHMLAIGSLDHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQL 134 Query: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK---PHAS 350 + + +I G+ ++ +V+R+L N+LL V+++D G+A ++ Sbjct: 135 LLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSE 194 Query: 351 VGTH-GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLT 408 T +MA E + G Y +D +S G +++L+ G P+ + + ++ + Sbjct: 195 AKTPIKWMALESIHFG-KYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDL--LEKG 251 Query: 409 MAVELPDSFSPELRSLLEGLLQRDVNRR 436 + P + ++ ++ D N R Sbjct: 252 ERLAQPQICTIDVYMVMVKCWMIDENIR 279 >2PMN-X nrPDB Length = 348 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 128/314 (40%), Gaps = 49/314 (15%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI------ 241 +ND+ + R + +G F ++ C K K YA+K +K ++ K+ T + N++I Sbjct: 30 INDYRIIRTLNQGKFNKIILCEK--DNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKY 87 Query: 242 -----MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDL------HYHLSQH--GV 288 L +++ + + D++ I + M + + L ++ Sbjct: 88 DDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCF 147 Query: 289 FSEADMRFYAAEIILGLEHMH-NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 347 ++ ++ ++H + + +RD+KP+NIL+D++G V++SD G + KK Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKI 207 Query: 348 HASVGTHGYMAPEVLQKGVAY-DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMT 406 S GT+ +M PE +Y + D +SLG L+ + PF + E+ Sbjct: 208 KGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKIS--LVELFNNI 265 Query: 407 LTMAVELP-------------------DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEV 447 T +E P + S E L+ L+++ R+ +++ Sbjct: 266 RTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERI-----TSEDA 320 Query: 448 KESPFFRSLDWQMV 461 + + + + + Sbjct: 321 LKHEWLADTNIEDL 334 >3RAW-A nrPDB Length = 381 Score = 175 bits (444), Expect = 5e-44, Method: Composition-based stats. Identities = 68/358 (18%), Positives = 122/358 (34%), Gaps = 77/358 (21%) Query: 166 IESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGK-MYAMKCLDK 224 +E DK L + + +G G FG+V C GK A+K + + Sbjct: 33 VEDDKEGHLVCRIGDWLQ-----ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKII-R 86 Query: 225 KRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS 284 K ++ L +N + + V MS F+ + +L+ L Sbjct: 87 NVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNT-FEFLK 145 Query: 285 QHG--VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL----------------- 325 ++ + +R A ++ L +H + + DLKP NIL Sbjct: 146 ENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEE 205 Query: 326 --DEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFK 383 ++ +R++D G A F + V T Y PEV+ + + + D +S+GC+LF+ Sbjct: 206 KSVKNTSIRVADFGSAT-FDHEHHTTIVATRHYRPPEVILE-LGWAQPCDVWSIGCILFE 263 Query: 384 LLRGHSPFRQHKTKDKHEIDRMTLTMAVE-----------------LPDSFSPELR---- 422 RG + F+ H+ ++ + L + D S + R Sbjct: 264 YYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKE 323 Query: 423 --------------------SLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQM 460 L+ +L+ D +R+ E PFF L + Sbjct: 324 NCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITL-----AEALLHPFFAGLTPEE 376 >2QKW-B nrPDB Length = 321 Score = 174 bits (442), Expect = 9e-44, Method: Composition-based stats. Identities = 69/297 (23%), Positives = 112/297 (37%), Gaps = 30/297 (10%) Query: 166 IESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK 225 + S F ++ +++ N+F +IG G FG+VY D G A+K ++ Sbjct: 16 LSSSYLVPFESYRVPLVDLEEATNNFDHKFLIGHGVFGKVYKGVLRD-GAKVALK---RR 71 Query: 226 RIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ 285 + QG E LS P +V + +++ I M G+L HL Sbjct: 72 TPESSQGIEEFETEIETLSF---CRHPHLVSLIGFCDERNEMILIYKYMENGNLKRHLYG 128 Query: 286 HG----VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLAC- 340 S GL ++H R +++RD+K NILLDE+ +I+D G++ Sbjct: 129 SDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKK 188 Query: 341 --DFSKKKPHASV-GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK 397 + + V GT GY+ PE KG +D +S G +LF++L S Q + Sbjct: 189 GTELDQTHLSTVVKGTLGYIDPEYFIKGR-LTEKSDVYSFGVVLFEVLCARSAIVQSLPR 247 Query: 398 DK----------HEIDRMTLTMAVELPDSFSPE----LRSLLEGLLQRDVNRRLGCL 440 + H ++ + L D PE L R Sbjct: 248 EMVNLAEWAVESHNNGQLEQIVDPNLADKIRPESLRKFGDTAVKCLALSSEDRPSMG 304 >2H34-A nrPDB Length = 309 Score = 174 bits (441), Expect = 1e-43, Method: Composition-based stats. Identities = 58/253 (22%), Positives = 105/253 (41%), Gaps = 15/253 (5%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + R++GRGG G+VY ++ A+K + + T E + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQE-- 93 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN 310 P +V + +L + L+NG DL L + G + +I L+ H Sbjct: 94 -PHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHA 152 Query: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH---ASVGTHGYMAPEVLQKGVA 367 +RD+KP NIL+ + D G+A + +K +VGT YMAPE + A Sbjct: 153 AGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHA 212 Query: 368 YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE----LRS 423 AD ++L C+L++ L G P++ D+ + + A+ P + P + Sbjct: 213 -TYRADIYALTCVLYECLTGSPPYQG----DQLSVMGAHINQAIPRPSTVRPGIPVAFDA 267 Query: 424 LLEGLLQRDVNRR 436 ++ + ++ R Sbjct: 268 VIARGMAKNPEDR 280 >2RIO-A nrPDB Length = 434 Score = 170 bits (432), Expect = 1e-42, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 118/308 (38%), Gaps = 50/308 (16%) Query: 194 HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPF 253 +I+G G G V + + G+ A+K + + E L E + D P Sbjct: 20 EKILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFCDIALMEIKLLTE--------SDDHPN 70 Query: 254 IVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMR-------FYAAEIILGLE 306 ++ + T L L+L N +L + V E +I G+ Sbjct: 71 VIRYYCSETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVA 129 Query: 307 HMHNRFVVYRDLKPANILLD-------------EHGHVRISDLGLACDFSKKK------P 347 H+H+ +++RDLKP NIL+ E+ + ISD GL + Sbjct: 130 HLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNL 189 Query: 348 HASVGTHGYMAPEVLQKG------VAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKH 400 + GT G+ APE+L++ S D FS+GC+ + +L G PF +++ + Sbjct: 190 NNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESN 249 Query: 401 EIDRMTLTMAVELPDSFS--PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDW 458 I + ++ S E L+ ++ D +R A +V P F Sbjct: 250 IIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKR-----PTAMKVLRHPLFWPKSK 304 Query: 459 QMVFLQKY 466 ++ FL K Sbjct: 305 KLEFLLKV 312 >3MDY-A nrPDB Length = 337 Score = 170 bits (430), Expect = 2e-42, Method: Composition-based stats. Identities = 68/292 (23%), Positives = 106/292 (36%), Gaps = 52/292 (17%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + IG+G +GEV+ + G+ A+K ET +M Sbjct: 39 IQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLMR------- 89 Query: 251 CPFIVCMSYAFHTPD----KLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 I+ A +L I D G L+ +L + M A + GL Sbjct: 90 HENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYL-KSTTLDAKSMLKLAYSSVSGLC 148 Query: 307 HMHNR--------FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK------PHASVG 352 H+H + +RDLK NIL+ ++G I+DLGLA F P+ VG Sbjct: 149 HLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVG 208 Query: 353 THGYMAPEVLQKGVAYDS-----SADWFSLGCMLFKLLRG----------HSPFRQHKTK 397 T YM PEVL + + + AD +S G +L+++ R P+ Sbjct: 209 TKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPS 268 Query: 398 DKHEIDRM----TLTMAVELPDSFSPE--LRS---LLEGLLQRDVNRRLGCL 440 D D + P+ +S + LR L+ + RL L Sbjct: 269 DPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTAL 320 >2BUJ-A nrPDB Length = 317 Score = 170 bits (430), Expect = 3e-42, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 110/299 (36%), Gaps = 31/299 (10%) Query: 178 KNVELNIHLTMND---FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGET 234 +N+ H+ + D + + +G GGF V G YA+K + +Q Sbjct: 15 ENLYFQGHMVIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRI---LCHEQQDRE 71 Query: 235 LALNERIMLSLVSTGDCPFIVCMSYAFHTP----DKLSFILDLMNGGDLHYHLS----QH 286 A E M L + P I+ + + +L G L + + Sbjct: 72 EAQREADMHRL---FNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKG 128 Query: 287 GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACD----- 341 +E + + I GLE +H + +RDLKP NILL + G + DLG Sbjct: 129 NFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHV 188 Query: 342 ------FSKKKPHASVGTHGYMAPEVLQKGVAY--DSSADWFSLGCMLFKLLRGHSPFRQ 393 + + A T Y APE+ D D +SLGC+L+ ++ G P+ Sbjct: 189 EGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDM 248 Query: 394 HKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQ-EVKESP 451 K + +++ S L LL ++ D ++R +Q E + P Sbjct: 249 VFQKGDSVALAVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQLEALQPP 307 >2WTK-B nrPDB Length = 373 Score = 169 bits (429), Expect = 3e-42, Method: Composition-based stats. Identities = 65/324 (20%), Positives = 116/324 (35%), Gaps = 68/324 (20%) Query: 191 FSVHRIIGRGGFG---EVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + + +IG+G F V R TG+ ++ ++ + + L + L + Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFL----QGELHVSK 65 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH--GVFSEADMRFYAAEIILGL 305 + P IV F ++L + M G + H +E + + ++ L Sbjct: 66 LFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKAL 125 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDL---------GLACDFSKKKPHASVGTHGY 356 +++H+ V+R +K ++IL+ G V +S L G P SV + Sbjct: 126 DYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPW 185 Query: 357 MAPEVLQKG-VAYDSSADWFSLGCMLFKLLRGHSPFRQHKTK---------------DKH 400 ++PEVLQ+ YD+ +D +S+G +L GH PF+ D Sbjct: 186 LSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTS 245 Query: 401 EIDRMTLTMAV----------------------------ELPDSFSPELRSLLEGLLQRD 432 I LTM+ +FSP +E LQR+ Sbjct: 246 TIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRN 305 Query: 433 VNRRLGCLGRGAQEVKESPFFRSL 456 + R A + FF+ + Sbjct: 306 PDAR-----PSASTLLNHSFFKQI 324 >3MY0-A nrPDB Length = 305 Score = 169 bits (428), Expect = 4e-42, Method: Composition-based stats. Identities = 64/299 (21%), Positives = 109/299 (36%), Gaps = 46/299 (15%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 + +G+G +GEV+ G+ A+K + + ET N ++ G Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILG--- 66 Query: 253 FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH--- 309 FI + ++ +L I G L+ L Q A GL H+H Sbjct: 67 FIASDMTSRNSSTQLWLITHYHEHGSLYDFL-QRQTLEPHLALRLAVSAACGLAHLHVEI 125 Query: 310 -----NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH------ASVGTHGYMA 358 + +RD K N+L+ + I+DLGLA S+ + VGT YMA Sbjct: 126 FGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMA 185 Query: 359 PEVLQKGVAYD-----SSADWFSLGCMLFKLLRG----------HSPFRQHKTKDKHEID 403 PEVL + + D D ++ G +L+++ R PF D D Sbjct: 186 PEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFED 245 Query: 404 RMTLTM----AVELPDSFSPE-----LRSLLEGLLQRDVNRRLGCL--GRGAQEVKESP 451 + +P+ + + L ++ + + RL L + Q++ SP Sbjct: 246 MKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSP 304 >5TE0-A nrPDB Length = 347 Score = 168 bits (425), Expect = 8e-42, Method: Composition-based stats. Identities = 60/302 (19%), Positives = 117/302 (38%), Gaps = 50/302 (16%) Query: 192 SVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDC 251 +V ++ GGF V+ R G A+K + + + + E ++ +S Sbjct: 22 TVDEVLAEGGFAIVFLVR-TSNGMKCALKRM---FVNNEHDLQVCKREIQIMRDLS--GH 75 Query: 252 PFIVCMSYAFHTP---DKLS---FILDLMNGGDLHYHLSQH--GVFSEADMRFYAAEIIL 303 IV + + ++D GG + ++Q F+E ++ + Sbjct: 76 KNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCE 135 Query: 304 GLEHMHNRF--VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH----------ASV 351 + +H +++RDLK NILL + GH + D G A + + Sbjct: 136 AVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKY 195 Query: 352 GTHGYMAPEV--LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTM 409 T Y APE+ L G + AD ++LGC+L+KL PF + + Sbjct: 196 TTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVA--------ICDG 247 Query: 410 AVELPDS--FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYP 467 +PD+ +S ++ L+ +L+ D ++R ++ + +F + ++ P Sbjct: 248 NFTIPDNSRYSQDMHCLIRYMLEPDPDKR--------PDIYQVSYFS----FKLLKKECP 295 Query: 468 PP 469 P Sbjct: 296 IP 297 >6HV0-A nrPDB Length = 416 Score = 166 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 67/287 (23%), Positives = 114/287 (39%), Gaps = 33/287 (11%) Query: 196 IIGRGGFGE-VYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 254 ++G G G VY + A+K + + E L E + + P + Sbjct: 15 VLGHGAEGTIVYRGM--FDNRDVAVKRILPECFSFADREVQLLRE--------SDEHPNV 64 Query: 255 VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEA-DMRFYAAEIILGLEHMHNRFV 313 + ++L L ++ Q + + GL H+H+ + Sbjct: 65 IRYFCTEKDRQFQYIAIELCA-ATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNI 123 Query: 314 VYRDLKPANILL---DEHGHVR--ISDLGLACDF-----SKKKPHASVGTHGYMAPEVLQ 363 V+RDLKP NIL+ + HG ++ ISD GL S + GT G++APE+L Sbjct: 124 VHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLS 183 Query: 364 KGVAY--DSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 + + D FS GC+ + ++ G PF + + I ++ P+ Sbjct: 184 EDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACSLDCLHPEKHEDV 242 Query: 421 -LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKY 466 R L+E ++ D +R A+ V + PFF SL+ Q+ F Q Sbjct: 243 IARELIEKMIAMDPQKR-----PSAKHVLKHPFFWSLEKQLQFFQDV 284 >4CRL-A nrPDB Length = 406 Score = 166 bits (421), Expect = 3e-41, Method: Composition-based stats. Identities = 69/331 (20%), Positives = 132/331 (39%), Gaps = 83/331 (25%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKM--YAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 ++ ++ GRG +G VY ++ D YA+K + +G ++++ ++L+ Sbjct: 24 EYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQI--------EGTGISMSACREIALLR 74 Query: 248 TGDCPFIVCMSYAF--HTPDKLSFILDLMNGGDLHYHLSQHGV---------FSEADMRF 296 P ++ + F H K+ + D DL + + H ++ Sbjct: 75 ELKHPNVISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQLPRGMVKS 133 Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILL----DEHGHVRISDLGLACDFSKK-----KP 347 +I+ G+ ++H +V++RDLKPANIL+ E G V+I+D+G A F+ Sbjct: 134 LLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADL 193 Query: 348 HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPF----RQHKTKDKHEID 403 V T Y APE+L Y + D +++GC+ +LL F KT + + D Sbjct: 194 DPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHD 253 Query: 404 RMTLTMAV-------------ELPDSFSPELRS--------------------------- 423 ++ V ++P+ S ++ Sbjct: 254 QLDRIFNVMGFPADKDWEDIKKMPEH-STLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAF 312 Query: 424 -LLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 LL+ LL D +R+ +++ + P+F Sbjct: 313 HLLQKLLTMDPIKRI-----TSEQAMQDPYF 338 >3VHK-A nrPDB Length = 368 Score = 165 bits (418), Expect = 6e-41, Method: Composition-based stats. Identities = 49/195 (25%), Positives = 83/195 (42%), Gaps = 17/195 (8%) Query: 261 FHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKP 320 F LS + + DL+ + + Y+ ++ G+E + +R ++RDL Sbjct: 174 FVEEKSLSDVEEEEAPEDLY-----KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAA 228 Query: 321 ANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG----YMAPEVLQKGVAYDSSADWFS 376 NILL E V+I D GLA D K + G +MAPE + V Y +D +S Sbjct: 229 RNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRV-YTIQSDVWS 287 Query: 377 LGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNR 435 G +L+++ G SP+ K D+ R+ + PD +PE+ + + ++ Sbjct: 288 FGVLLWEIFSLGASPYPGVKI-DEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQ 346 Query: 436 RLGCLGRGAQEVKES 450 R E+ E Sbjct: 347 R-----PTFSELVEH 356 Score = 70.8 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 23/116 (19%), Positives = 43/116 (37%), Gaps = 10/116 (8%) Query: 178 KNVELNIHLTMNDFSVHRIIGRGGFGEV-----YGCRKADTGKMYAMKCLDKKRIKMKQG 232 + + + +GRG FG+V +G K T + A+K L + + Sbjct: 18 PYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR 77 Query: 233 ETLALNERIMLSLVSTGDCPFIVCMSYAFHTP-DKLSFILDLMNGGDLHYHLSQHG 287 L +I++ + G +V + A P L I++ G+L +L Sbjct: 78 -ALMSELKILIHI---GHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKR 129 >4PL5-B nrPDB Length = 435 Score = 165 bits (417), Expect = 7e-41, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 113/288 (39%), Gaps = 35/288 (12%) Query: 196 IIGRGGFGE-VYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 254 ++G G G VY + A+K + + E L E + + P + Sbjct: 34 VLGHGAEGTIVYKGMF--DNRDVAVKRILPECFSFADREVQLLRE--------SDEHPNV 83 Query: 255 VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEA-DMRFYAAEIILGLEHMHNRFV 313 + ++L L ++ Q + + GL H+H+ + Sbjct: 84 IRYFCTEKDRQFQYIAIELCA-ATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNI 142 Query: 314 VYRDLKPANILL---DEHGHVR--ISDLGLACDF-----SKKKPHASVGTHGYMAPEVLQ 363 V+RDLKP NILL + HG ++ ISD GL S + GT G++APE+L Sbjct: 143 VHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLS 202 Query: 364 KGVAY--DSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 + + D FS GC+ + ++ G+ PF + + I + + Sbjct: 203 EDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGACNLDC-FHSDKHED 260 Query: 421 --LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKY 466 R L+E ++ D +R A+ V + PFF SL+ Q+ F Q Sbjct: 261 VIARELIEKMIAMDPQQR-----PSAKHVLKHPFFWSLEKQLQFFQDV 303 >3SV0-A nrPDB Length = 483 Score = 164 bits (415), Expect = 1e-40, Method: Composition-based stats. Identities = 75/340 (22%), Positives = 124/340 (36%), Gaps = 42/340 (12%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 N F + R IG G FGE+Y T + A+K + K + L +I L Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQ----LLYESKIYRILQGG 62 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAAEIILGLE 306 P V D ++DL+ DL S+ S + A ++I +E Sbjct: 63 TGIPN-VRWFGV--EGDYNVLVMDLLGPSLEDLFNFCSRK--LSLKTVLMLADQMINRVE 117 Query: 307 HMHNRFVVYRDLKPANILLD---EHGHVRISDLGLACDFSKKKPHASV---------GTH 354 +H++ ++RD+KP N L+ V I D GLA + H + GT Sbjct: 118 FVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTA 177 Query: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKT----KDKHEIDRMTLTMA 410 Y + G+ D SLG +L LRG P++ K + +I + + Sbjct: 178 RYASVNT-HLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVATS 236 Query: 411 VE-LPDSFSPELRSLLEGL--LQRDVNRRLGCLGRGAQEVKESPFFRS-------LDWQM 460 +E L + E S L+ D L R +++ F R DW + Sbjct: 237 IEALCRGYPTEFASYFHYCRSLRFDDKPDYSYLKRLFRDL----FIREGFQFDYVFDWTI 292 Query: 461 VFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLD 500 + Q+ PPR + A + ++ + + + Sbjct: 293 LKYQQSQIASAPPRAVGHGAGPSGLAPPALQNDRQSGVDE 332 >4JLC-A nrPDB Length = 657 Score = 164 bits (414), Expect = 2e-40, Method: Composition-based stats. Identities = 48/237 (20%), Positives = 96/237 (40%), Gaps = 23/237 (9%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 + I+G+G V+ R TG +YA+K + I + + + E ++ + Sbjct: 12 LSDILGQGATANVFRGRHKKTGDLYAVKVFN--NISFLRPVDVQMRE---FEVLKKLNHK 66 Query: 253 FIVCMSYAFHTPD--KLSFILDLMNGGDLHYHLSQHGV---FSEADMRFYAAEIILGLEH 307 IV + I++ G L+ L + E++ +++ G+ H Sbjct: 67 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 126 Query: 308 MHNRFVVYRDLKPANIL--LDEHGH--VRISDLGLACDFSKKKPHAS-VGTHGYMAPEVL 362 + +V+RD+KP NI+ + E G +++D G A + + S GT Y+ P++ Sbjct: 127 LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 186 Query: 363 QK-------GVAYDSSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAV 411 ++ Y ++ D +S+G + G PFR + E+ +T Sbjct: 187 ERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 243 >5XD6-A nrPDB Length = 305 Score = 164 bits (414), Expect = 2e-40, Method: Composition-based stats. Identities = 54/230 (23%), Positives = 90/230 (39%), Gaps = 25/230 (10%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 +++ +IG G +G V+ +GK A+K LD KQ + L + M+S + Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLD----SSKQPDQEFLAQVSMVSRLRQ 76 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG---------VFSEADMRFYAA 299 +V + + G LH L V S A Sbjct: 77 E---NVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAV 133 Query: 300 EIILGLEHMHNR---FVVYRDLKPANILLDEHGHVRISDLGLACDFSKK----KPHASVG 352 GLE++H + V++RD+K +N+LL + +I+D L+ +G Sbjct: 134 GAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLG 193 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI 402 T GY APE G + +D +S G +L +LL G P + + + Sbjct: 194 TFGYHAPEYAMTG-TLSTKSDVYSFGVVLLELLTGRKPVDHTLPRGQQSV 242 >2Y4I-B nrPDB Length = 319 Score = 164 bits (414), Expect = 2e-40, Method: Composition-based stats. Identities = 58/278 (20%), Positives = 105/278 (37%), Gaps = 27/278 (9%) Query: 176 QWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL 235 Q + + +IG+G FG+VY R A++ +D +R E Sbjct: 20 QTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIER----DNEDQ 72 Query: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADM 294 + + +V A +P L+ I L G L+ + V Sbjct: 73 LKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKT 132 Query: 295 RFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLG-------LACDFSKKKP 347 R A EI+ G+ ++H + ++++DLK N+ D +G V I+D G L + K Sbjct: 133 RQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKL 191 Query: 348 HASVGTHGYMAPEVL--------QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 399 G ++APE++ + + + +D F+LG + ++L PF+ + Sbjct: 192 RIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAI 251 Query: 400 HEIDRMTLTMAVELPD-SFSPELRSLLEGLLQRDVNRR 436 I +M M L E+ +L + R Sbjct: 252 --IWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEER 287 >6DC0-A nrPDB Length = 292 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 56/257 (21%), Positives = 92/257 (35%), Gaps = 25/257 (9%) Query: 205 VYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTP 264 V TG+ K K + K + + I + Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDK-----------IRPYIQLPSHSNITGIVEVILGE 70 Query: 265 DKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANIL 324 K + + GD+H ++ E + +I+ + H H +V DLK + Sbjct: 71 TKAYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFV 129 Query: 325 L--DEHGHVRISDLG--LACDFSKKKPHASVGTHGYMAPEVLQKGVAYD-SSADWFSLGC 379 +E +R+ L G Y++PE+L Y +AD +SLG Sbjct: 130 FSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGV 189 Query: 380 MLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGC 439 ML+ LL G PF D + +P+ SP+ R L+ LL+R+ + RL Sbjct: 190 MLYTLLVGRYPFHD---SDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERL-- 244 Query: 440 LGRGAQEVKESPFFRSL 456 A E+ P+F S+ Sbjct: 245 ---TAPEILLHPWFESV 258 >1PY5-A nrPDB Length = 326 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 64/290 (22%), Positives = 112/290 (38%), Gaps = 52/290 (17%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 + IG+G FGEV+ + G+ A+K + + E ++ Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERSWFREAEIYQTVMLR-------HE 83 Query: 253 FIVCMSYAFHTPD----KLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 I+ A + + +L + D G L +L+++ V E ++ A GL H+ Sbjct: 84 NILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIK-LALSTASGLAHL 142 Query: 309 H--------NRFVVYRDLKPANILLDEHGHVRISDLGL------ACDFSKKKPHASVGTH 354 H + +RDLK NIL+ ++G I+DLGL A D P+ VGT Sbjct: 143 HMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTK 202 Query: 355 GYMAPEVLQKGVAYD-----SSADWFSLGCMLFKLLRG----------HSPFRQHKTKD- 398 YMAPEVL + AD +++G + +++ R P+ D Sbjct: 203 RYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDP 262 Query: 399 -KHEIDRM--TLTMAVELPDSF-SPEL----RSLLEGLLQRDVNRRLGCL 440 E+ ++ + +P+ + S E ++ + RL L Sbjct: 263 SVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTAL 312 >4EUU-A nrPDB Length = 319 Score = 163 bits (412), Expect = 3e-40, Method: Composition-based stats. Identities = 46/237 (19%), Positives = 96/237 (40%), Gaps = 23/237 (9%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 + I+G+G V+ R TG ++A+K + I + + + E ++ + Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMRE---FEVLKKLNHK 67 Query: 253 FIVCMSYAFHTPD--KLSFILDLMNGGDLHYHLSQHGV---FSEADMRFYAAEIILGLEH 307 IV + I++ G L+ L + E++ +++ G+ H Sbjct: 68 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 127 Query: 308 MHNRFVVYRDLKPANIL--LDEHGH--VRISDLGLACDFSKKKPHAS-VGTHGYMAPEVL 362 + +V+R++KP NI+ + E G +++D G A + + S GT Y+ P++ Sbjct: 128 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 187 Query: 363 QK-------GVAYDSSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAV 411 ++ Y ++ D +S+G + G PFR + E+ +T Sbjct: 188 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 244 >5CEK-A nrPDB Length = 263 Score = 163 bits (412), Expect = 3e-40, Method: Composition-based stats. Identities = 56/257 (21%), Positives = 92/257 (35%), Gaps = 25/257 (9%) Query: 205 VYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTP 264 V TG+ K K + K + + I + Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDK-----------IRPYIQLPSHSNITGIVEVILGE 73 Query: 265 DKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANIL 324 K + + GD+H ++ E + +I+ + H H +V DLK + Sbjct: 74 TKAYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFV 132 Query: 325 L--DEHGHVRISDLG--LACDFSKKKPHASVGTHGYMAPEVLQKGVAYD-SSADWFSLGC 379 +E +R+ L G Y++PE+L Y +AD +SLG Sbjct: 133 FSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGV 192 Query: 380 MLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGC 439 ML+ LL G PF D + +P+ SP+ R L+ LL+R+ + RL Sbjct: 193 MLYTLLVGRYPFHD---SDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERL-- 247 Query: 440 LGRGAQEVKESPFFRSL 456 A E+ P+F S+ Sbjct: 248 ---TAPEILLHPWFESV 261 >4EUT-A nrPDB Length = 396 Score = 162 bits (410), Expect = 5e-40, Method: Composition-based stats. Identities = 46/237 (19%), Positives = 96/237 (40%), Gaps = 23/237 (9%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 + I+G+G V+ R TG ++A+K + I + + + E ++ + Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMRE---FEVLKKLNHK 67 Query: 253 FIVCMSYAFHTPD--KLSFILDLMNGGDLHYHLSQHGV---FSEADMRFYAAEIILGLEH 307 IV + I++ G L+ L + E++ +++ G+ H Sbjct: 68 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 127 Query: 308 MHNRFVVYRDLKPANIL--LDEHGH--VRISDLGLACDFSKKKPHAS-VGTHGYMAPEVL 362 + +V+R++KP NI+ + E G +++D G A + + S GT Y+ P++ Sbjct: 128 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 187 Query: 363 QK-------GVAYDSSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAV 411 ++ Y ++ D +S+G + G PFR + E+ +T Sbjct: 188 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 244 >4TN6-A nrPDB Length = 318 Score = 161 bits (407), Expect = 9e-40, Method: Composition-based stats. Identities = 53/240 (22%), Positives = 92/240 (38%), Gaps = 24/240 (10%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 N + + R IG G FG++Y G+ A+K + L + +I + Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKL----ECVKTKHPQLHIESKIYKMMQGG 62 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAAEIILGLE 306 P I + D +++L+ DL S+ FS + A ++I +E Sbjct: 63 VGIPTI---RWCGAEGDYNVMVMELLGPSLEDLFNFCSRK--FSLKTVLLLADQMISRIE 117 Query: 307 HMHNRFVVYRDLKPANILLD---EHGHVRISDLGLACDFSKKKPHASV---------GTH 354 ++H++ ++RD+KP N L+ + V I D GLA + + H + GT Sbjct: 118 YIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTA 177 Query: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP 414 Y + G+ D SLG +L G P++ K K + + P Sbjct: 178 RYASINT-HLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTP 236 >5AR8-A nrPDB Length = 326 Score = 161 bits (407), Expect = 1e-39, Method: Composition-based stats. Identities = 63/268 (23%), Positives = 105/268 (39%), Gaps = 23/268 (8%) Query: 194 HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPF 253 R + RG G V R AD A+K L + L E ++ + Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLRE---AEILHKARFSY 93 Query: 254 IVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSE--ADMRF-YAAEIILGLEHMHN 310 I+ + + P+ L + + M G L+ L + + + +RF EI LG+ ++HN Sbjct: 94 ILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHN 153 Query: 311 R--FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASV-------GTHGYMAPEV 361 +++ DLK NILLD HV+I+D GL+ + GT YM PE Sbjct: 154 MTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPEN 213 Query: 362 LQKGVAY--DSSADWFSLGCMLFKLLRGHSPFRQHKT--KDKHEIDRMTLTMAVE--LPD 415 + G D +S + +++L PF + + + + + E LP Sbjct: 214 YEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPY 273 Query: 416 SFSPELR--SLLEGLLQRDVNRRLGCLG 441 R SL+E ++ + R L Sbjct: 274 DIPHRARMISLIESGWAQNPDERPSFLK 301 >4M66-A nrPDB Length = 325 Score = 160 bits (405), Expect = 2e-39, Method: Composition-based stats. Identities = 60/275 (21%), Positives = 105/275 (38%), Gaps = 37/275 (13%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 ++ + +G+GGFG V+ A+K ++ K+I + + Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWE------------VKA 64 Query: 246 VSTGDCPFIVCMSYAFHTPDKLS-----FILDLMNGGDLHYHLSQHGVFSEADMRFYAAE 300 + ++ + + M G L L + E Sbjct: 65 MVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQE 124 Query: 301 IILGLEHMHNRF--VVYRDLKPANILLDEHGHVRISDLGLAC--------DFSKKKPHAS 350 ++LG+ ++H+ +++RDLKP+NILLD H +++D GL+ S S Sbjct: 125 VVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDS 184 Query: 351 VGTHGYMAPEVLQK-GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE--IDRMTL 407 GT Y+ PE+L K + ++D +S G +++ +L G KT E DR + Sbjct: 185 GGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSR 244 Query: 408 TMAVELPDSFSPE------LRSLLEGLLQRDVNRR 436 ELP SPE L+ L+ R Sbjct: 245 PPLTELPPG-SPETPGLEKLKELMIHCWGSQSENR 278 >5IKW-A nrPDB Length = 310 Score = 159 bits (403), Expect = 3e-39, Method: Composition-based stats. Identities = 54/276 (19%), Positives = 105/276 (38%), Gaps = 37/276 (13%) Query: 192 SVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDC 251 ++ + GGF V+ R G A+K + + + E ++ +S Sbjct: 17 TLEESLAEGGFSTVFLVRTHG-GIRCALKRMYVNNMPDLN---VCKREITIMKELS--GH 70 Query: 252 PFIVCMSYAFHTP--DKLS---FILDLMNGGDLHYHLSQH--GVFSEADMRFYAAEIILG 304 IV D + +++ G + +++ F+E ++ + Sbjct: 71 KNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEA 130 Query: 305 LEHMHNRF--VVYRDLKPANILLDEHGHVRISDLGLA--CDFSKKKPHASVG-------- 352 + +H +++RDLK NILL++ G+ + D G A + +K +V Sbjct: 131 VARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYT 190 Query: 353 THGYMAPEVLQ--KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA 410 T Y APE++ G + AD ++LGC+L+KL PF + + Sbjct: 191 TLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVA--------ICDGN 242 Query: 411 VELPDS--FSPELRSLLEGLLQRDVNRRLGCLGRGA 444 +PD+ +S + L+ +L+ D R Sbjct: 243 FTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSY 278 >4IAN-A nrPDB Length = 358 Score = 159 bits (403), Expect = 3e-39, Method: Composition-based stats. Identities = 61/320 (19%), Positives = 117/320 (36%), Gaps = 70/320 (21%) Query: 198 GRGGFGEVYGCRKA-DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 G+G F V R + A+K + + K G L L+ D + Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG-LKELEFLKKLNDADPDDKFHCLR 97 Query: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV---FSEADMRFYAAEIILGLEHMHNRFV 313 + F+ L + + ++ +L L ++G +R Y+ ++ L L+ + + Sbjct: 98 LFRHFYHKQHLCLVFEPLSM-NLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNI 156 Query: 314 VYRDLKPANILLDEHGHV-RISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSA 372 ++ D+KP NIL++E + ++ D G A + + + Y APE++ G +YD Sbjct: 157 LHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIII-GKSYDYGI 215 Query: 373 DWFSLGCMLFKLLRGHSPFRQHKT------------------------KDKH-------- 400 D +S+GC L++L G F KD+H Sbjct: 216 DMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFM 275 Query: 401 --EIDRMTLTMAVELPDSFSPE-----------------------LRSLLEGLLQRDVNR 435 E+D++T V + + +P L+ LL+ +L D + Sbjct: 276 YIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAK 335 Query: 436 RLGCLGRGAQEVKESPFFRS 455 R+ + + F + Sbjct: 336 RISIN-----QALQHAFIQE 350 >2JD5-A nrPDB Length = 373 Score = 159 bits (402), Expect = 4e-39, Method: Composition-based stats. Identities = 65/332 (19%), Positives = 127/332 (38%), Gaps = 78/332 (23%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + + R +G G F V+ + AMK + ++ + E +E +L V+ Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAE----DEIKLLQRVNDA 75 Query: 250 DC--------PFIVCMSYAFHTPD----KLSFILDLMNGGDLHYHLSQ--HGVFSEADMR 295 D I+ + F+ + + +++ G +L + + H ++ Sbjct: 76 DNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVL-GENLLALIKKYEHRGIPLIYVK 134 Query: 296 FYAAEIILGLEHMHNR-FVVYRDLKPANILL------DEHGHVRISDLGLACDFSKKKPH 348 + +++LGL++MH R +++ D+KP N+L+ + ++I+DLG AC + + Sbjct: 135 QISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY-DEHYT 193 Query: 349 ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHK----TKDKHEIDR 404 S+ T Y +PEVL G + AD +S C++F+L+ G F + TKD I + Sbjct: 194 NSIQTREYRSPEVLL-GAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQ 252 Query: 405 MT-----------------------------------------LTMAVELPDSFSPELRS 423 + LT + + E+ Sbjct: 253 IIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISD 312 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 L +LQ D +R A + P+ + Sbjct: 313 FLSPMLQLDPRKR-----ADAGGLVNHPWLKD 339 >6NT9-A nrPDB Length = 742 Score = 159 bits (401), Expect = 5e-39, Method: Composition-based stats. Identities = 46/237 (19%), Positives = 96/237 (40%), Gaps = 23/237 (9%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 + I+G+G V+ R TG ++A+K + I + + + E ++ + Sbjct: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMRE---FEVLKKLNHK 65 Query: 253 FIVCMSYAFHTPD--KLSFILDLMNGGDLHYHLSQHGV---FSEADMRFYAAEIILGLEH 307 IV + I++ G L+ L + E++ +++ G+ H Sbjct: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 Query: 308 MHNRFVVYRDLKPANIL--LDEHGH--VRISDLGLACDFSKKKPHAS-VGTHGYMAPEVL 362 + +V+R++KP NI+ + E G +++D G A + + S GT Y+ P++ Sbjct: 126 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 Query: 363 QK-------GVAYDSSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAV 411 ++ Y ++ D +S+G + G PFR + E+ +T Sbjct: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 >6O8B-A nrPDB Length = 665 Score = 158 bits (400), Expect = 6e-39, Method: Composition-based stats. Identities = 45/237 (18%), Positives = 95/237 (40%), Gaps = 23/237 (9%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 + I+G+G V+ R TG ++A+K + I + + + E ++ + Sbjct: 19 LSDILGQGATANVFRGRHKKTGDLFAIKVFN--NISFLRPVDVQMRE---FEVLKKLNHK 73 Query: 253 FIVCMSYAFHTPD--KLSFILDLMNGGDLHYHLSQHGV---FSEADMRFYAAEIILGLEH 307 IV + I++ G L+ L + E++ +++ G+ H Sbjct: 74 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 133 Query: 308 MHNRFVVYRDLKPANIL--LDEHGH--VRISDLGLACDFSKKKPHAS-VGTHGYMAPEVL 362 + +V+R++KP NI+ + E G +++D G A + + GT Y+ P++ Sbjct: 134 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMY 193 Query: 363 QK-------GVAYDSSADWFSLGCMLFKLLRGHSPFRQ-HKTKDKHEIDRMTLTMAV 411 ++ Y ++ D +S+G + G PFR + E+ +T Sbjct: 194 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 250 >3QD2-B nrPDB Length = 332 Score = 157 bits (398), Expect = 1e-38, Method: Composition-based stats. Identities = 63/343 (18%), Positives = 117/343 (34%), Gaps = 89/343 (25%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 + DF + +GRGGFG V+ + YA+K + + E + + + L Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPN-RELAREKVMREVKALAKLEH 63 Query: 248 TGDCPFI-----------------------------------------VCMSYAFHTPD- 265 G + + F T + Sbjct: 64 PGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNT 123 Query: 266 -----------KLSFILDLMNGGDLHYHLSQHGVFSEAD---MRFYAAEIILGLEHMHNR 311 L + L +L +++ + + +I +E +H++ Sbjct: 124 VGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSK 183 Query: 312 FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP--------------HASVGTHGYM 357 +++RDLKP+NI V++ D GL + + VGT YM Sbjct: 184 GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYM 243 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA-VELPDS 416 +PE + G Y D FSLG +LF+LL + + E R+ + ++ P Sbjct: 244 SPEQIH-GNNYSHKVDIFSLGLILFELL--------YSFSTQMERVRIITDVRNLKFPLL 294 Query: 417 FS---PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 F+ P+ +++ +L R A ++ E+ F +L Sbjct: 295 FTQKYPQEHMMVQDMLSPSPTER-----PEATDIIENAIFENL 332 >5FQD-C nrPDB Length = 341 Score = 156 bits (394), Expect = 3e-38, Method: Composition-based stats. Identities = 53/257 (20%), Positives = 90/257 (35%), Gaps = 29/257 (11%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + R IG G FG++Y G+ A+K + + L ++ L Sbjct: 21 YKLVRKIGSGSFGDIYLAINITNGEEVAVKL----ESQKARHPQLLYESKLYKILQGGVG 76 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 P I D ++DL+ DL S+ F+ + A ++I +E++ Sbjct: 77 IPHIRWYG---QEKDYNVLVMDLLGPSLEDLFNFCSRR--FTMKTVLMLADQMISRIEYV 131 Query: 309 HNRFVVYRDLKPANILLDEHGHV---RISDLGLACDFSKKKPHASV---------GTHGY 356 H + ++RD+KP N L+ H + D GLA + + + GT Y Sbjct: 132 HTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARY 191 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP-- 414 + G+ D SLG +L R P++ K K + + P Sbjct: 192 ASINA-HLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVE 250 Query: 415 ---DSFSPELRSLLEGL 428 F E L Sbjct: 251 VLCKGFPAEFAMYLNYC 267 >5E8V-A nrPDB Length = 316 Score = 155 bits (392), Expect = 6e-38, Method: Composition-based stats. Identities = 59/297 (19%), Positives = 102/297 (34%), Gaps = 55/297 (18%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTG----KMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 + ++G+G F EVY + + A+K + + E ++ + Sbjct: 11 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK--- 67 Query: 247 STGDCPFIVCMSYAFHTPDKL----SFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEII 302 I+ A +L I G+L +L++H V S D+R + + Sbjct: 68 ----HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-VISWEDLRKLGSSLA 122 Query: 303 LGLEHMHN---------RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK------KP 347 G+ H+H+ +V+RDLK +NIL+ + D GL+ Sbjct: 123 RGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLAN 182 Query: 348 HASVGTHGYMAPEVL-----QKGVAYDSSADWFSLGCMLFKLLRG----------HSPF- 391 VGT YMAPEVL + V D +S+ +L+++ PF Sbjct: 183 SGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFG 242 Query: 392 ---RQHKTKDKHEIDRMTLTMAVELPDSFS-----PELRSLLEGLLQRDVNRRLGCL 440 R+H + + E+P + + L D RL Sbjct: 243 SKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQ 299 >2C47-A nrPDB Length = 313 Score = 155 bits (391), Expect = 7e-38, Method: Composition-based stats. Identities = 59/258 (22%), Positives = 99/258 (38%), Gaps = 31/258 (12%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 +F V + IG G FGE+ + T + A+K + L L R L +T Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPIKSRAPQLHLEYRFYKQLSATE 60 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 P + Y + +L+L+ DL + F+ + A ++I +E+ Sbjct: 61 GVPQV---YYFGPCGKYNAMVLELLGPSLEDLFDLCDR--TFTLKTVLMIAIQLITRMEY 115 Query: 308 MHNRFVVYRDLKPANILLDEHGH-----VRISDLGLACDFSKKKPHASV---------GT 353 +H + ++YRD+KP N L+ G + I D GLA ++ + + GT Sbjct: 116 VHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGT 175 Query: 354 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVEL 413 YM+ G D +LG M LRG P++ K E + Sbjct: 176 ARYMSINT-HLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRAT 234 Query: 414 P-----DSFSPELRSLLE 426 P ++F E+ + L Sbjct: 235 PIEVLCENFPEEMATYLR 252 >5L2Q-C nrPDB Length = 320 Score = 154 bits (389), Expect = 1e-37, Method: Composition-based stats. Identities = 62/285 (21%), Positives = 111/285 (38%), Gaps = 51/285 (17%) Query: 206 YGCRKADTGKMYAMKCLDKKR--------IKMKQGETLALNERIMLSLVSTGDCPFIVCM 257 RK T Y +K L + + +QG+ L E +LSL+ T D +V Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDG--VVHH 90 Query: 258 SYAFHT------------------PDKLSFILDLMNGGD----------LHYHLSQHGVF 289 F ++ +LD + D L +++ + Sbjct: 91 HGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRL 150 Query: 290 SEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGH-VRISDLGLACDFSKKKP- 347 SE + +++ +E +H + +V+RDLK N++L++ H + I++ L + Sbjct: 151 SERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDL 210 Query: 348 -HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMT 406 G+ Y++P+VL +D ++LG +LF +L G PF + E+ R Sbjct: 211 LKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQ---ELFRKI 267 Query: 407 LTMAVELPDS--FSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKE 449 +P+ S L+ LL D +RL A +V E Sbjct: 268 KAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRL-----AAADVLE 307 >2CMW-A nrPDB Length = 310 Score = 154 bits (389), Expect = 1e-37, Method: Composition-based stats. Identities = 57/256 (22%), Positives = 100/256 (39%), Gaps = 30/256 (11%) Query: 192 SVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDC 251 V + IG G FGE+ + T + A+K + L L R L S G+ Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPIKSRAPQLHLEYRFYKQLGSAGEG 58 Query: 252 PFIVCMSYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 + + Y + +L+L+ DL + F+ + A +++ +E++H Sbjct: 59 --LPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR--TFTLKTVLMIAIQLLSRMEYVH 114 Query: 310 NRFVVYRDLKPANILLDEHGH-----VRISDLGLACDFSKKKPHASV---------GTHG 355 ++ ++YRD+KP N L+ G+ + I D GLA ++ + + GT Sbjct: 115 SKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTAR 174 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP- 414 YM+ G D +LG M LRG P++ K E + P Sbjct: 175 YMSINT-HLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPI 233 Query: 415 ----DSFSPELRSLLE 426 ++F E+ + L Sbjct: 234 EALCENFPEEMATYLR 249 >3G2F-A nrPDB Length = 336 Score = 153 bits (387), Expect = 2e-37, Method: Composition-based stats. Identities = 59/314 (18%), Positives = 106/314 (33%), Gaps = 57/314 (18%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 L +++ + +IGRG +G VY + + A+K +Q N + + Sbjct: 10 LDLDNLKLLELIGRGRYGAVYKGSLDE--RPVAVKVFS---FANRQNFINEKNIYRVPLM 64 Query: 246 VSTGDCPFIVCMSYAFHTPD-KLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 FIV + +++ G L +LS H + R A + G Sbjct: 65 EHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCR-LAHSVTRG 123 Query: 305 LEHMHNR---------FVVYRDLKPANILLDEHGHVRISDLGLACDFS----------KK 345 L ++H + +RDL N+L+ G ISD GL+ + Sbjct: 124 LAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDN 183 Query: 346 KPHASVGTHGYMAPEVLQKGVAYD------SSADWFSLGCMLFKLLRGHS-PFRQHKTKD 398 + VGT YMAPEVL+ V D ++LG + +++ + F + Sbjct: 184 AAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPE 243 Query: 399 KHEIDRMTLT----------------MAVELPDSFSP------ELRSLLEGLLQRDVNRR 436 + + + P+++ L+ +E +D R Sbjct: 244 YQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEAR 303 Query: 437 LG--CLGRGAQEVK 448 L C E+ Sbjct: 304 LTAQCAEERMAELM 317 >2CHL-A nrPDB Length = 351 Score = 153 bits (387), Expect = 2e-37, Method: Composition-based stats. Identities = 56/233 (24%), Positives = 92/233 (39%), Gaps = 26/233 (11%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 +F V + IG G FGE+ + T + A+K K + L L R L S Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMK----SRAPQLHLEYRFYKQLGSGD 86 Query: 250 DCPFIVCMSYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAAEIILGLEH 307 P + Y + +L+L+ DL + FS + A ++I +E+ Sbjct: 87 GIPQV---YYFGPCGKYNAMVLELLGPSLEDLFDLCDR--TFSLKTVLMIAIQLISRMEY 141 Query: 308 MHNRFVVYRDLKPANILLDEHGH-----VRISDLGLACDFSKKKPHASV---------GT 353 +H++ ++YRD+KP N L+ G+ + I D LA ++ + + GT Sbjct: 142 VHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGT 201 Query: 354 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMT 406 YM+ G D +LG M LRG P++ K E + Sbjct: 202 ARYMSINT-HLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKI 253 >4RT7-A nrPDB Length = 415 Score = 153 bits (386), Expect = 3e-37, Method: Composition-based stats. Identities = 49/221 (22%), Positives = 91/221 (41%), Gaps = 22/221 (9%) Query: 243 LSLVSTGDCPFIVCMSY-AFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 + D I + +FH+ D++ + N L V + D+ +A ++ Sbjct: 198 REVQIHPDSDQISGLHGNSFHSEDEI----EYENQKRLEEE-EDLNVLTFEDLLCFAYQV 252 Query: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG----YM 357 G+E + + V+RDL N+L+ V+I D GLA D + G +M Sbjct: 253 AKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWM 312 Query: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 APE L +G+ Y +D +S G +L+++ G +P+ D + + ++ P Sbjct: 313 APESLFEGI-YTIKSDVWSYGILLWEIFSLGVNPYPGIPV-DANFYKLIQNGFKMDQPFY 370 Query: 417 FSPELRSLLEGLLQRDVNRR---------LGCLGRGAQEVK 448 + E+ +++ D +R LGC A+E Sbjct: 371 ATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAM 411 Score = 88.5 bits (218), Expect = 1e-17, Method: Composition-based stats. Identities = 29/127 (22%), Positives = 47/127 (37%), Gaps = 11/127 (8%) Query: 168 SDKFTRFCQWKNVE--LNIHLTMNDFSVHRIIGRGGFGEV-----YGCRKADTGKMYAMK 220 SD + ++ E L + +++G G FG+V YG K A+K Sbjct: 42 SDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVK 101 Query: 221 CLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLH 280 L K++ + E L ++M L G IV + A + I + GDL Sbjct: 102 ML-KEKADSSEREALMSELKMMTQL---GSHENIVNLLGACTLSGPIYLIFEYCCYGDLL 157 Query: 281 YHLSQHG 287 +L Sbjct: 158 NYLRSKR 164 >6BFN-A nrPDB Length = 342 Score = 153 bits (386), Expect = 3e-37, Method: Composition-based stats. Identities = 52/244 (21%), Positives = 86/244 (35%), Gaps = 24/244 (9%) Query: 177 WKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA 236 W E I ++FS IG GGFG VY +T +YA+K L + + Sbjct: 12 WPLCE--ISRGTHNFSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQS 67 Query: 237 LNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL----SQHGVFSEA 292 + +S P IV + + + G L L S Sbjct: 68 F--LTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWP 125 Query: 293 DMRFYAAEIILGLEHMH--NRFVVYRDLKPANILLDEHGHVRISDLGLACD--------- 341 ++ +H + +++ D+K +N+LLDE ++ D GLA Sbjct: 126 QRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPS 185 Query: 342 --FSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK 399 + GT Y+ E ++ G D FS G ++ + L G + H + K Sbjct: 186 QSSMVARTQTVRGTLAYLPEEYIKTGR-LAVDTDTFSFGVVVLETLAGQRAVKTHGARTK 244 Query: 400 HEID 403 + D Sbjct: 245 YLKD 248 >3SOC-A nrPDB Length = 322 Score = 151 bits (382), Expect = 8e-37, Method: Composition-based stats. Identities = 64/311 (20%), Positives = 108/311 (34%), Gaps = 54/311 (17%) Query: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 N++ + + RG FG V+ + + A+K + + Q E Sbjct: 18 NLYFQSMPLQLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNE-------YE 68 Query: 243 LSLVSTGDCPFIVCMSYAFHTPD----KLSFILDLMNGGDLHYHLSQHGVFSEADMRFYA 298 + + I+ A L I G L L + V S ++ A Sbjct: 69 VYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL-KANVVSWNELCHIA 127 Query: 299 AEIILGLEHMHN----------RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK-- 346 + GL ++H + +RD+K N+LL + I+D GLA F K Sbjct: 128 ETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSA 187 Query: 347 --PHASVGTHGYMAPEVLQKGVAYDS----SADWFSLGCMLFKLLRGH-----------S 389 H VGT YMAPEVL+ + + D +++G +L++L Sbjct: 188 GDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYML 247 Query: 390 PFR----QHKTKDKHEIDRMTLTMAVELPDSFSPEL-----RSLLEGLLQRDVNRRL--G 438 PF QH + + + + L D + +E D RL G Sbjct: 248 PFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAG 307 Query: 439 CLGRGAQEVKE 449 C+G +++ Sbjct: 308 CVGERITQMQR 318 >4BTK-A nrPDB Length = 337 Score = 150 bits (379), Expect = 2e-36, Method: Composition-based stats. Identities = 52/258 (20%), Positives = 95/258 (36%), Gaps = 24/258 (9%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 ++ + + V + IG GGFGE+Y T + A+K +Q + + E +L Sbjct: 52 YVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ESAQQPKQVLKMEVAVLK 106 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADMRFYAAEII 302 + D + ++ L G +L G F+ + +I+ Sbjct: 107 KLQGKDH--VCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQIL 163 Query: 303 LGLEHMHNRFVVYRDLKPANI----LLDEHGHVRISDLGLACDFSKKKPHAS-------- 350 +E +H+ ++RD+KP+N L + + D GLA ++ Sbjct: 164 ESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF 223 Query: 351 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA 410 GT Y A K D +SL ML + G P+R+ K K++ + + Sbjct: 224 RGTVRY-ASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHR 282 Query: 411 VELPDSFSPELRSLLEGL 428 + L E L+ + Sbjct: 283 M-LLKHMPSEFHLFLDHI 299 >4NFN-A nrPDB Length = 309 Score = 150 bits (378), Expect = 3e-36, Method: Composition-based stats. Identities = 52/258 (20%), Positives = 95/258 (36%), Gaps = 24/258 (9%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 ++ + + V + IG GGFGE+Y T + A+K +Q + + E +L Sbjct: 17 YVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ESAQQPKQVLKMEVAVLK 71 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADMRFYAAEII 302 + D + ++ L G +L G F+ + +I+ Sbjct: 72 KLQGKDH--VCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQIL 128 Query: 303 LGLEHMHNRFVVYRDLKPANI----LLDEHGHVRISDLGLACDFSKKKPHAS-------- 350 +E +H+ ++RD+KP+N L + + D GLA ++ Sbjct: 129 ESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF 188 Query: 351 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA 410 GT Y A K D +SL ML + G P+R+ K K++ + + Sbjct: 189 RGTVRY-ASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHR 247 Query: 411 VELPDSFSPELRSLLEGL 428 + L E L+ + Sbjct: 248 M-LLKHMPSEFHLFLDHI 264 >4F9B-A nrPDB Length = 361 Score = 148 bits (374), Expect = 7e-36, Method: Composition-based stats. Identities = 66/354 (18%), Positives = 107/354 (30%), Gaps = 101/354 (28%) Query: 189 NDFSVHRIIGRGGFGEVYGCR---KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 N F + IG G F VY + + A+K L ++ L L Sbjct: 21 NVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQC-------L 73 Query: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 G ++ + Y F D + + + L+ S ++R Y + L Sbjct: 74 TVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNS---LSFQEVREYMLNLFKAL 130 Query: 306 EHMHNRFVVYRDLKPANILLDEHGHVR-ISDLGLACDFSKKKPH---------------- 348 + +H +V+RD+KP+N L + + D GLA K Sbjct: 131 KRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQ 190 Query: 349 --------------ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR-- 392 GT G+ APEVL K ++ D +S G + LL G PF Sbjct: 191 NKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKA 250 Query: 393 ----------------------------------QHKTKDKHEIDRMTLTMA-------- 410 + +D ++ M Sbjct: 251 SDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTS 310 Query: 411 --------VELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 +E + E LL+ LL + R+ A+E PFF+ + Sbjct: 311 DIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRI-----TAEEALLHPFFKDM 359 >2X7G-A nrPDB Length = 389 Score = 148 bits (374), Expect = 8e-36, Method: Composition-based stats. Identities = 74/338 (21%), Positives = 122/338 (36%), Gaps = 74/338 (21%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + V R +G G F V+ C + AMK + + AL+E +L V Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK----SAQHYTETALDEIKLLKCVRES 87 Query: 250 D--CPF---IVCMSYAFHTPD----KLSFILDLMNGGDLHYHLSQH-GVFSEADMRFYAA 299 D P +V + F + + +++ L + + + ++ Sbjct: 88 DPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIR 147 Query: 300 EIILGLEHMHNR-FVVYRDLKPANIL---------------------------------- 324 +++ GL+++H++ +++ D+KP NIL Sbjct: 148 QVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTA 207 Query: 325 ---------LDEHG----HVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSS 371 LD V+I+DLG AC K + T Y + EVL G Y + Sbjct: 208 PAADLLVNPLDPRNADKIRVKIADLGNACWVH-KHFTEDIQTRQYRSIEVLI-GAGYSTP 265 Query: 372 ADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQR 431 AD +S CM F+L G F H +D + D + +EL S L G R Sbjct: 266 ADIWSTACMAFELATGDYLFEPHSGED-YSRDEDHIAHIIELLGSIPRHFA--LSGKYSR 322 Query: 432 DVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPP 469 + R G L R ++K F V ++KY P Sbjct: 323 EFFNRRGEL-RHITKLKPWSLF------DVLVEKYGWP 353 >4NT4-A nrPDB Length = 312 Score = 148 bits (373), Expect = 1e-35, Method: Composition-based stats. Identities = 60/262 (22%), Positives = 95/262 (36%), Gaps = 33/262 (12%) Query: 190 DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 +F V + IG G FGE+ + + A+K K + L L R L S Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMK----SKAPQLHLEYRFYKLLGSHA 68 Query: 250 DC-----PFIVCMSYAFHTPDKLSFILDLMNGGDLHY-HLSQHGVFSEADMRFYAAEIIL 303 D P I + + +L+L+ G L FS + A +++ Sbjct: 69 DNAPDGIPRIYHLGTC--GGRYNAMVLELL-GLSLEDLFNICARKFSLKTVLMIAKQLLH 125 Query: 304 GLEHMHNRFVVYRDLKPANILLDEHGH-----VRISDLGLACDFSKKKPHASV------- 351 +E++H+R ++YRD+KP N L+ + I D GLA ++ + + Sbjct: 126 RIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKS 185 Query: 352 --GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTM 409 GT YM+ G D +LG M LRG P++ K E + Sbjct: 186 LTGTARYMSINT-HMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDT 244 Query: 410 AVELP-----DSFSPELRSLLE 426 P D E + L Sbjct: 245 KRATPIEVLCDGHPEEFATYLR 266 >2QLU-A nrPDB Length = 314 Score = 147 bits (370), Expect = 2e-35, Method: Composition-based stats. Identities = 63/296 (21%), Positives = 109/296 (36%), Gaps = 55/296 (18%) Query: 199 RGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMS 258 RG FG V+ + + A+K + + Q E + M ++ Sbjct: 25 RGRFGCVWKAQLMND--FVAVKIFPLQDKQSWQSEREIFSTPGMK-------HENLLQFI 75 Query: 259 YAFHTPD----KLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHN---- 310 A +L I + G L +L + + + ++ A + GL ++H Sbjct: 76 AAEKRGSNLEVELWLITAFHDKGSLTDYL-KGNIITWNELCHVAETMSRGLSYLHEDVPW 134 Query: 311 -------RFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP----HASVGTHGYMAP 359 + +RD K N+LL ++D GLA F KP H VGT YMAP Sbjct: 135 CRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAP 194 Query: 360 EVLQKGVAYDS----SADWFSLGCMLFKLLRGH-----------SPFR----QHKTKDKH 400 EVL+ + + D +++G +L++L+ PF QH + ++ Sbjct: 195 EVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEEL 254 Query: 401 EIDRMTLTMAVELPDSF--SPELRSL---LEGLLQRDVNRRL--GCLGRGAQEVKE 449 + + M + D + P L L +E D RL GC+ ++ Sbjct: 255 QEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRR 310 >5X18-A nrPDB Length = 295 Score = 145 bits (365), Expect = 8e-35, Method: Composition-based stats. Identities = 55/253 (21%), Positives = 93/253 (36%), Gaps = 30/253 (11%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + + + IG G FG ++ G A+K +K + +E +++ Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQ-----LRDEYKTYKILN--G 61 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEHMH 309 P I Y ++DL+ G L G FS + A ++I +E +H Sbjct: 62 TPNIPYAYYFGQEGLHNILVIDLL-GPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLH 120 Query: 310 NRFVVYRDLKPANILLDEHGH-----VRISDLGLACDFSKKKPHASV---------GTHG 355 ++YRD+KP N L+ G + + D G+A + K + GT Sbjct: 121 AHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTAR 180 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPD 415 YM+ G D +LG + F LRGH P++ K + + Sbjct: 181 YMSINT-HLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGE------K 233 Query: 416 SFSPELRSLLEGL 428 S + L +GL Sbjct: 234 KRSTNVYDLAQGL 246 >4XHH-A nrPDB Length = 403 Score = 144 bits (363), Expect = 1e-34, Method: Composition-based stats. Identities = 56/265 (21%), Positives = 96/265 (36%), Gaps = 29/265 (10%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F + R IG G FG++Y +G+ A+ + + L R+ L Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAI----RLESIRSRHPQLDYESRVYKYLSGGVG 64 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 PFI + + + ++DL+ DL + H FS + A ++I ++++ Sbjct: 65 IPFI---RWFGREGEYNAMVIDLLGPSLEDLFNYC--HRKFSFKTVIMLALQMICRVQYI 119 Query: 309 HNRFVVYRDLKPANILLD---EHGHVRISDLGLACDFSKKKPHASV---------GTHGY 356 H R ++RD+KP N L+ V + D GL+ + H + GT Y Sbjct: 120 HGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARY 179 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV----- 411 + G+ D SLG ML +G P++ K K + L + Sbjct: 180 ASVNT-HLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCISVE 238 Query: 412 ELPDSFSPELRSLLEGLLQRDVNRR 436 L E + + R Sbjct: 239 TLCAGLPLEFSEYMNYCRNLKFDER 263 >4XHL-A nrPDB Length = 394 Score = 142 bits (359), Expect = 4e-34, Method: Composition-based stats. Identities = 55/257 (21%), Positives = 97/257 (37%), Gaps = 29/257 (11%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 F + R IG G FG++Y +G+ A+ + + L R+ L Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAI----RLESIRSRHPQLDYESRVYRYLSGGVG 64 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGG--DLHYHLSQHGVFSEADMRFYAAEIILGLEHM 308 PFI + + + ++DL+ DL + H FS + A ++ ++++ Sbjct: 65 IPFI---RWFGREGEYNAMVIDLLGPSLEDLFNYC--HRRFSFKTVIMLALQMFCRIQYI 119 Query: 309 HNRFVVYRDLKPANILLD---EHGHVRISDLGLACDFSKKKPHASV---------GTHGY 356 H R ++RD+KP N L+ V + D GL+ + H + GT Y Sbjct: 120 HGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARY 179 Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKT----KDKHEIDRMTLTMAVE 412 + G+ D SLG +L +G P++ K + I L ++VE Sbjct: 180 ASVNT-HLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVE 238 Query: 413 -LPDSFSPELRSLLEGL 428 L E + + Sbjct: 239 TLCSGLPLEFQEYMAYC 255 >4WUA-A nrPDB Length = 401 Score = 141 bits (356), Expect = 8e-34, Method: Composition-based stats. Identities = 71/404 (17%), Positives = 122/404 (30%), Gaps = 122/404 (30%) Query: 163 QKFIESDKFTRFCQWKNVELNIHLTM------NDFSVHRIIGRGGFGEVYGCRKADTGKM 216 ++ + SD + + HL + V R +G G F V+ K Sbjct: 9 EEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKF 68 Query: 217 YAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD--CPF---IVCMSYAFH----TPDKL 267 AMK + + AL+E +L V D P +V + F + Sbjct: 69 VAMKVVK----SAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHI 124 Query: 268 SFILDLMNGGDLHYHLSQH-GVFSEADMRFYAAEIILGLEHMHNR-FVVYRDLKPANILL 325 + +++ L + + + ++ +++ GL+++H + +++ D+KP NILL Sbjct: 125 CMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL 184 Query: 326 D-------------------------------------------------EHGHVRISDL 336 E V+I+DL Sbjct: 185 SVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADL 244 Query: 337 GLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKT 396 G AC K + T Y + EVL G Y++ AD +S CM F+L G F H Sbjct: 245 GNACWVH-KHFTEDIQTRQYRSLEVLI-GSGYNTPADIWSTACMAFELATGDYLFEPHSG 302 Query: 397 K--------------------------------------DKHEIDRMT-------LTMAV 411 + D I ++ L Sbjct: 303 EEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKY 362 Query: 412 ELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 E + L +L+ +R A E P+ S Sbjct: 363 EWSQEEAAGFTDFLLPMLELIPEKR-----ATAAECLRHPWLNS 401 >5M07-A nrPDB Length = 276 Score = 139 bits (351), Expect = 3e-33, Method: Composition-based stats. Identities = 59/279 (21%), Positives = 103/279 (36%), Gaps = 39/279 (13%) Query: 178 KNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLAL 237 ++ L +T ++V R++G GEVY + A+K L + Sbjct: 19 SHMALASGVTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQ 78 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQH--GVFSEADMR 295 E + + + P I+ + +L +D ++G D H++ V ++ Sbjct: 79 RETEVAARL---FHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVL 135 Query: 296 FYAAEIILGLEHMHNRFVVYRDLKPANILLDE----HGHVRISDLGLACDFSKKKPHASV 351 + L++ H R +++RD+ PAN++L + ++D G+A Sbjct: 136 AIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ---------- 185 Query: 352 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAV 411 Y APE L G D AD ++L L G P +DR + T + Sbjct: 186 --PSYPAPE-LSAGADVDGRADQYALALTAIHLFAGAPP-----------VDR-SHTGPL 230 Query: 412 ELP--DSFSPELRSL---LEGLLQRDVNRRLGCLGRGAQ 445 + P +F P+L L L L R G A Sbjct: 231 QPPKLSAFRPDLARLDGVLSRALATAPADRFGSCREFAD 269 >1CSN-A nrPDB Length = 298 Score = 138 bits (349), Expect = 6e-33, Method: Composition-based stats. Identities = 52/255 (20%), Positives = 86/255 (33%), Gaps = 29/255 (11%) Query: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 + V R IG G FG ++ + A+K ++ L R L Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRR----SDAPQLRDEYRTYKLLAGCTG 67 Query: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLEHMH 309 P + Y ++DL+ G L L G FS + A +++ ++ +H Sbjct: 68 IPNV---YYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIH 123 Query: 310 NRFVVYRDLKPANILLDEHGH-----VRISDLGLACDFSKKKPHASV---------GTHG 355 + +VYRD+KP N L+ + + D G+ + + GT Sbjct: 124 EKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTAR 183 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTL-----TMA 410 YM+ G D +LG + LRG P++ K + T Sbjct: 184 YMSINT-HLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTPL 242 Query: 411 VELPDSFSPELRSLL 425 EL F E + Sbjct: 243 RELCAGFPEEFYKYM 257 >5CLR-A nrPDB Length = 451 Score = 137 bits (346), Expect = 1e-32, Method: Composition-based stats. Identities = 75/369 (20%), Positives = 137/369 (37%), Gaps = 49/369 (13%) Query: 206 YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPD 265 + D GK Y +K + + T NE+ LS + + F Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESL----TEFTNEKDTLSKLG--------RLVGTFFNEQ 143 Query: 266 K--LSFILDLMNGGDLHYH---LSQHGVFSE-ADMRFYAAEIILGLEHMHNRFVVYRDLK 319 + + G DL + L + ++ + ++ H +++RDLK Sbjct: 144 TQVHYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLK 203 Query: 320 PANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEV--LQKGVAYDSSADWFSL 377 P NI+LD + D G + + KP AS GT Y+APE+ + +A+ +D F+L Sbjct: 204 PGNIMLDADMQCHLVDFGSSSSDKEPKP-ASWGTASYLAPELNAQEDFIAFSQVSDLFAL 262 Query: 378 GCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRL 437 L +L +PFRQ K + + + E+ + + GL+ + + R Sbjct: 263 AYSLDELF---NPFRQVKFAKVDIGIKNKHLVLLH------AEIEACITGLMSNETSVRT 313 Query: 438 GCLGRGAQEVKESPFFRS----LDWQMVFLQKYPPPLIPPR---------------GEVN 478 R Q + F+S + ++ L ++ P E + Sbjct: 314 LYFSRILQLQRVPESFKSRPEAFTYLIMLLTQWKSCYEAPEMNKELDEIIAEIKVAYENH 373 Query: 479 AADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEA 538 DA I + E+ +K LL+S + L +++ QQE+ E+D + Sbjct: 374 EQDAVKIITLLEQLSKADGLLNSHKALLSVLIKSLANVQQQELGHDDILPRRFESDVVSR 433 Query: 539 RKKTKNKQL 547 KT ++ Sbjct: 434 LIKTPTAKM 442 >4JRN-A nrPDB Length = 372 Score = 133 bits (334), Expect = 3e-31, Method: Composition-based stats. Identities = 54/295 (18%), Positives = 97/295 (32%), Gaps = 51/295 (17%) Query: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS--------T 248 +G GGF VY +T + A+K ++ + E S Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 249 GDCPFIVCMSYAFHTPDK----------------LSFILDLMNGGDLHYHLS-------- 284 C F+V ++ D+ +S Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAE-ADMSKVISWVFGDASV 194 Query: 285 QHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK 344 F + +++ I + ++ + +V+ D+KPAN LL + G + + D G Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYR--IN 252 Query: 345 KKPHASVGTHGYMAPE--VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI 402 ++GT GY PE G+ Y D + LG L+ + P D Sbjct: 253 NSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYLHF 312 Query: 403 DRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 + P + ++ L+ LL RD +R+ L + E+ F+ +D Sbjct: 313 --------ADCPST-PELVQDLIRSLLNRDPQKRMLPL-----QALETAAFKEMD 353 >5OAT-A nrPDB Length = 411 Score = 131 bits (330), Expect = 9e-31, Method: Composition-based stats. Identities = 72/312 (23%), Positives = 113/312 (36%), Gaps = 65/312 (20%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADT----GKM-YAMKCLDKKRIKMKQGETLAL-- 237 +T+ND S+ + I +G G VY + D K +A+K + I+ E L Sbjct: 7 PITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMY 66 Query: 238 ----------------NERIML--SLVSTGDCPFIVCMSYAF--------------HTPD 265 N I L P IV + F Sbjct: 67 RETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEG 126 Query: 266 KLSFILDLMNGGD--LHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANI 323 + + LM D L LS S A+++ G+ HM + +RDLK N+ Sbjct: 127 RNMSLFLLMKRYDCNLQSFLSTAP--STRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNL 184 Query: 324 LLD----EHGHVRISDLGLACDFSKKK---PHASV-----GTHGYMAPEVLQKGVA---- 367 LLD E + ISD G P+ S G MAPE++ + Sbjct: 185 LLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSV 244 Query: 368 --YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 Y AD +++G + +++ H+PF L +LPD +++L+ Sbjct: 245 LNYS-KADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDL---PKLPDEVPTVIQALV 300 Query: 426 EGLLQRDVNRRL 437 LL+R+ N+RL Sbjct: 301 ANLLKRNPNKRL 312 >2PZI-A nrPDB Length = 681 Score = 127 bits (318), Expect = 2e-29, Method: Composition-based stats. Identities = 57/263 (21%), Positives = 97/263 (36%), Gaps = 27/263 (10%) Query: 191 FSVHRIIGRGGFGEVYGCRKAD-TGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + V I GG G +Y + G+ +K L Q +A ++ Sbjct: 82 YEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER-----QFLAEV 136 Query: 250 DCPFIVCMSYAFHTPDKL-----SFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 P IV + D+ +++ + G L S+ A+ Y EI+ Sbjct: 137 VHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAIAYLLEILPA 194 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 364 L ++H+ +VY DLKP NI+L E +++ DLG + GT G+ APE+++ Sbjct: 195 LSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGY--LYGTPGFQAPEIVRT 251 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 424 G + D +++G L L P R + D D L L Sbjct: 252 GP--TVATDIYTVGRTLAAL-TLDLPTRNGRYVDGLPEDDPVLKTYDSYGR--------L 300 Query: 425 LEGLLQRDVNRRLGCLGRGAQEV 447 L + D +R + ++ Sbjct: 301 LRRAIDPDPRQRFTTAEEMSAQL 323 >4Y12-A nrPDB Length = 375 Score = 126 bits (317), Expect = 3e-29, Method: Composition-based stats. Identities = 57/263 (21%), Positives = 97/263 (36%), Gaps = 27/263 (10%) Query: 191 FSVHRIIGRGGFGEVYGCRKAD-TGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG 249 + V I GG G +Y + G+ +K L Q +A ++ Sbjct: 121 YEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER-----QFLAEV 175 Query: 250 DCPFIVCMSYAFHTPDKL-----SFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 P IV + D+ +++ + G L S+ A+ Y EI+ Sbjct: 176 VHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAIAYLLEILPA 233 Query: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 364 L ++H+ +VY DLKP NI+L E +++ DLG + GT G+ APE+++ Sbjct: 234 LSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGY--LYGTPGFQAPEIVRT 290 Query: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSL 424 G + D +++G L L P R + D D L L Sbjct: 291 GP--TVATDIYTVGRTLAAL-TLDLPTRNGRYVDGLPEDDPVLKTYDSYGR--------L 339 Query: 425 LEGLLQRDVNRRLGCLGRGAQEV 447 L + D +R + ++ Sbjct: 340 LRRAIDPDPRQRFTTAEEMSAQL 362 >5UU1-A nrPDB Length = 324 Score = 124 bits (312), Expect = 1e-28, Method: Composition-based stats. Identities = 54/252 (21%), Positives = 97/252 (38%), Gaps = 26/252 (10%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYA---MKC--------LDKKRIKMKQGETLAL 237 N + + + IG GGFG +Y + + A +K + + + + + Sbjct: 16 NQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCI 75 Query: 238 NERIMLSLVSTGDCP-FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRF 296 + I + P F F +++ + G DL Q+G F ++ + Sbjct: 76 KKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQNGTFKKSTVLQ 134 Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLD--EHGHVRISDLGLACDFSKKKPHASV--- 351 ++ LE++H V+ D+K AN+LL V ++D GL+ + H Sbjct: 135 LGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQEN 194 Query: 352 ------GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRM 405 GT + + + KGVA +D LG + + L G P+ Q+ KD + Sbjct: 195 PRKGHNGTIEFTSLDA-HKGVALSRRSDVEILGYCMLRWLCGKLPWEQN-LKDPVAVQTA 252 Query: 406 TLTMAVELPDSF 417 + ELP S Sbjct: 253 KTNLLDELPQSV 264 >4MWI-A nrPDB Length = 294 Score = 123 bits (310), Expect = 2e-28, Method: Composition-based stats. Identities = 38/246 (15%), Positives = 91/246 (36%), Gaps = 21/246 (8%) Query: 217 YAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHT----PDKLSFILD 272 A+K K + N+ I + + P I+ + P + S +++ Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEI--KTMKKFESPNILRIFGICIDETVTPPQFSIVME 107 Query: 273 LMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFV--VYRDLKPANILLDEHGH 330 G L L + + GL +H+ ++ ++ +N L+ + Sbjct: 108 YCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQ 167 Query: 331 VRISDLGLACDFSK------KKPHASVGTHGYMAPEVLQKGVA-YDSSADWFSLGCMLFK 383 V+++ L + ++ V + Y++P+ L+ YD ++ +S G +L++ Sbjct: 168 VKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWE 227 Query: 384 LLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRG 443 + G PF+ ++ ++ + L + ELR +++ D + R Sbjct: 228 IATGDIPFQGCNSEKIRKLVAVK-RQQEPLGEDCPSELREIIDECRAHDPSVR-----PS 281 Query: 444 AQEVKE 449 E+ + Sbjct: 282 VDEILK 287 >4M69-B nrPDB Length = 283 Score = 123 bits (310), Expect = 2e-28, Method: Composition-based stats. Identities = 37/236 (15%), Positives = 83/236 (35%), Gaps = 14/236 (5%) Query: 217 YAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHT----PDKLSFILD 272 +K + + + N + + D P I+ + P + S +++ Sbjct: 35 VTIKVFNNPQAESVGIVRFTFN--DEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVME 92 Query: 273 LMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVR 332 G L L + + + GL +H+ ++R++ ++ L+ V+ Sbjct: 93 YCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVK 152 Query: 333 ISDLGLACDFSKKKPHASVGTHG------YMAPEVLQKG-VAYDSSADWFSLGCMLFKLL 385 ++ L+ + A Y++PE L+ YD A+ +S G +L+++ Sbjct: 153 LAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIA 212 Query: 386 RGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLG 441 G PF +K E+ + LR ++ + ++R G Sbjct: 213 TGKIPFEGCDSKKIRELVAEDKK-QEPVGQDCPELLREIINECRAHEPSQRPSVDG 267 >6EQI-C nrPDB Length = 433 Score = 123 bits (308), Expect = 3e-28, Method: Composition-based stats. Identities = 55/331 (16%), Positives = 106/331 (32%), Gaps = 73/331 (22%) Query: 178 KNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTG-----KMYAMKCLDKKRIKMKQG 232 +NVE +++ + I +G VY + + A+K + ++ Sbjct: 4 ENVEQLQAANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNST 63 Query: 233 ETLALNERIMLSLVSTGD-------------------CPFIVCMSYAFHTPDK------- 266 L R + +S P IV M F Sbjct: 64 AILKAMYRETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQ 123 Query: 267 --------------------LSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 L ++ + L +L + ++++ + Sbjct: 124 LYPEALPPRINPEGSGRNMSLFLVMKRYD-CTLKEYLRDKTP-NMRSSILLLSQLLEAVA 181 Query: 307 HMHNRFVVYRDLKPANILL-----DEHGHVRISDLGLACDFSKK--------KPHASVGT 353 HM+ + +RDLK NIL+ D + + I+D G + + G Sbjct: 182 HMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGN 241 Query: 354 HGYMAPEVLQKGVAY-----DSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLT 408 MAPE+ +D +++G + +++ +PF K + + Sbjct: 242 RALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYK--EE 299 Query: 409 MAVELPDSFSPELRSLLEGLLQRDVNRRLGC 439 ELPD+ +R+L+ +L R N+RL C Sbjct: 300 DLPELPDTIPFIIRNLVSNMLSRSTNKRLDC 330 >3REP-A nrPDB Length = 271 Score = 122 bits (307), Expect = 5e-28, Method: Composition-based stats. Identities = 46/242 (19%), Positives = 92/242 (38%), Gaps = 18/242 (7%) Query: 203 GEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFH 262 GE++ R G +K L + ++ + P ++ + A Sbjct: 24 GELWKGRWQ--GNDIVVKVLKVRDWSTRKSRDFNEE----CPRLRIFSHPNVLPVLGACQ 77 Query: 263 TPD--KLSFILDLMNGGDLHYHLSQHGVF--SEADMRFYAAEIILGLEHMHN-RFVVYR- 316 +P + I M G L+ L + F ++ +A ++ G+ +H ++ R Sbjct: 78 SPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRH 137 Query: 317 DLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYD--SSADW 374 L ++++DE RIS +A + + ++APE LQK SAD Sbjct: 138 ALNSRSVMIDEDMTARIS---MADVKFSFQSPGRMYAPAWVAPEALQKKPEDTNRRSADM 194 Query: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVN 434 +S +L++L+ PF + + + +P SP + L++ + D Sbjct: 195 WSFAVLLWELVTREVPFADLSNMEIGMKVALE-GLRPTIPPGISPHVSKLMKICMNEDPA 253 Query: 435 RR 436 +R Sbjct: 254 KR 255 >4BTF-A nrPDB Length = 469 Score = 122 bits (306), Expect = 6e-28, Method: Composition-based stats. Identities = 37/236 (15%), Positives = 83/236 (35%), Gaps = 14/236 (5%) Query: 217 YAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHT----PDKLSFILD 272 +K + + + N + + D P I+ + P + S +++ Sbjct: 221 VTIKVFNNPQAESVGIVRFTFN--DEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVME 278 Query: 273 LMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVR 332 G L L + + + GL +H+ ++R++ ++ L+ V+ Sbjct: 279 YCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVK 338 Query: 333 ISDLGLACDFSKKKPHASVGTHG------YMAPEVLQKG-VAYDSSADWFSLGCMLFKLL 385 ++ L+ + A Y++PE L+ YD A+ +S G +L+++ Sbjct: 339 LAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIA 398 Query: 386 RGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLG 441 G PF +K E+ + LR ++ + ++R G Sbjct: 399 TGKIPFEGCDSKKIRELVAEDKK-QEPVGQDCPELLREIINECRAHEPSQRPSVDG 453 >4L00-A nrPDB Length = 304 Score = 122 bits (305), Expect = 7e-28, Method: Composition-based stats. Identities = 55/320 (17%), Positives = 115/320 (35%), Gaps = 42/320 (13%) Query: 176 QWKNVELNIHLTMN-----DFSVHRIIGRGGFGEVYGCR------KADTGKMYAMKCLDK 224 +W+ V L+ + D +GRG +Y T + +K + K Sbjct: 7 EWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILK 66 Query: 225 KRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS 284 + +LA E S++ IV + + + + + GG L + Sbjct: 67 VLDPSHRDISLAFFEA--ASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMH 124 Query: 285 QH-GVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGH-------VRISDL 336 + V + A ++ L ++ ++ +V+ ++ N+LL G +++SD Sbjct: 125 RKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDP 184 Query: 337 GLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHK 395 G+ ++ ++APE ++ +AD +S G L+++ G P + Sbjct: 185 GIPITVLSRQECIER--IPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKT 242 Query: 396 TKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 +K S EL L+ + D N+R PFFR+ Sbjct: 243 LIEKERFYESRCRPVT---PSC-KELADLMTRCMNYDPNQR--------------PFFRA 284 Query: 456 LDWQMVFLQKYPPPLIPPRG 475 + + L++ P ++ + Sbjct: 285 IMRDINKLEEQNPDIVSEKK 304 >5J0A-A nrPDB Length = 300 Score = 122 bits (305), Expect = 7e-28, Method: Composition-based stats. Identities = 41/280 (14%), Positives = 94/280 (33%), Gaps = 35/280 (12%) Query: 193 VHRIIGRGGFGE-VYGCRKADTGKMY---AMKCLDKKRIKMKQGETLALNERIMLSLVST 248 + +G G G VY +++ G + A+K ++ ++ + Sbjct: 13 FMQKLGFGT-GVNVYLMKRSPRGLSHSPWAVKKINPI-CNDHYRSVYQKRLMDEAKILKS 70 Query: 249 GDCPFIVCMSYAFH-TPDKLSFILDLMNGGDLHYHLSQH-----GVFSEADMRFYAAEII 302 P IV L ++ L+ + + F A + A + Sbjct: 71 LHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMA 130 Query: 303 LGLEHMHN-RFVVYRDLKPANILLDEHG-HVRISDLGLACDFSKKKPHA-----SVGTHG 355 GL+++H + +++ D+K +N+++ ++I D+G++ + +GT Sbjct: 131 RGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEP 190 Query: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSP--------------FRQHKTKDKHE 401 + E +++ AD F+ G L++++ P F + D+ Sbjct: 191 WKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAY 250 Query: 402 IDRMTLTMAV--ELPDSFSPELRSLLEGLLQRDVNRRLGC 439 + + E D ++ L D R Sbjct: 251 YAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSA 290 >5USZ-A nrPDB Length = 289 Score = 122 bits (305), Expect = 8e-28, Method: Composition-based stats. Identities = 41/265 (15%), Positives = 96/265 (36%), Gaps = 29/265 (10%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGK-------MYAMKCLDKKRIKMKQGETLALNERI 241 D + +G+G F +++ + + G +K LDK + A Sbjct: 8 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEA----- 62 Query: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAE 300 S++S +V D+ + + + G L +L ++ + A + Sbjct: 63 -ASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQ 121 Query: 301 IILGLEHMHNRFVVYRDLKPANILL--------DEHGHVRISDLGLACDFSKKKPHASVG 352 + + + +++ ++ NILL +++SD G++ K Sbjct: 122 LAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER- 180 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAV 411 ++ PE ++ + + D +S G L+++ G P ++ K + Sbjct: 181 -IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRH---- 235 Query: 412 ELPDSFSPELRSLLEGLLQRDVNRR 436 +LP + EL +L+ + + + R Sbjct: 236 QLPAPKAAELANLINNCMDYEPDHR 260 >5X1R-A nrPDB Length = 302 Score = 119 bits (299), Expect = 3e-27, Method: Composition-based stats. Identities = 48/280 (17%), Positives = 86/280 (30%), Gaps = 24/280 (8%) Query: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG--------------- 232 N+F + IG GGFG VY + A+K + + Sbjct: 20 FNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTF 79 Query: 233 ETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYH-LSQHGVFSE 291 + + L++ P ++ + + +G L Q E Sbjct: 80 QAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDE 139 Query: 292 ADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK--KPHA 349 A +R + + +H ++RD+ NI + E + D G A Sbjct: 140 AWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDETE 199 Query: 350 SVGTHGYMAPEVLQKGV--AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTL 407 V G+ E + D ++LG +L L+ G P I+ Sbjct: 200 IVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP----PVSVVRSIEDSYQ 255 Query: 408 TMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEV 447 + P +SPEL ++ L R + A+ + Sbjct: 256 PLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAELL 295 >5C01-A nrPDB Length = 342 Score = 116 bits (290), Expect = 4e-26, Method: Composition-based stats. Identities = 43/239 (17%), Positives = 84/239 (35%), Gaps = 22/239 (9%) Query: 208 CRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKL 267 R +K LD +AL SL+S + + + Sbjct: 101 GRDRGQELRVVLKVLDPS------HHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPEN 154 Query: 268 SFILDLMNGGDLHYHLSQ-HGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL- 325 + + + G L L + G A A ++ L ++ N+ +V+ ++ NILL Sbjct: 155 IMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLA 214 Query: 326 ------DEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVA-YDSSADWFSLG 378 +++SD G+ ++ ++APE L G ++ D + G Sbjct: 215 RLGLAEGTSPFIKLSDPGVGLGALSREERVER--IPWLAPECLPGGANSLSTAMDKWGFG 272 Query: 379 CMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 L ++ G +P + +K + LP+ P+L +L L + +R Sbjct: 273 ATLLEICFDGEAPLQSRSPSEKEHFYQRQH----RLPEPSCPQLATLTSQCLTYEPTQR 327 >4WOV-A nrPDB Length = 317 Score = 115 bits (289), Expect = 6e-26, Method: Composition-based stats. Identities = 43/239 (17%), Positives = 84/239 (35%), Gaps = 22/239 (9%) Query: 208 CRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKL 267 R +K LD +AL SL+S + + + Sbjct: 78 GRDRGQELRVVLKVLDPS------HHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPEN 131 Query: 268 SFILDLMNGGDLHYHLSQ-HGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL- 325 + + + G L L + G A A ++ L ++ N+ +V+ ++ NILL Sbjct: 132 IMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLA 191 Query: 326 ------DEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVA-YDSSADWFSLG 378 +++SD G+ ++ ++APE L G ++ D + G Sbjct: 192 RLGLAEGTSPFIKLSDPGVGLGALSREERVER--IPWLAPECLPGGANSLSTAMDKWGFG 249 Query: 379 CMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 L ++ G +P + +K + LP+ P+L +L L + +R Sbjct: 250 ATLLEICFDGEAPLQSRSPSEKEHFYQRQH----RLPEPSCPQLATLTSQCLTYEPTQR 304 >6J6I-B nrPDB Length = 351 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 34/205 (16%), Positives = 73/205 (35%), Gaps = 14/205 (6%) Query: 217 YAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNG 276 Y +K + I K+ + I+LS + + + + + Sbjct: 84 YMIKRFSEDEITGKRHRVKEVYNDIVLS-ARMSNHSNFLQLLGCCLEFPFPVLVFEFAEH 142 Query: 277 GDLHYH-----LSQHGVFSEADMRFYAAEIILGLEHMHN---RFVVYRDLKPANILLDEH 328 G ++ + + + EI + ++H + +++RD+KP ++ LD++ Sbjct: 143 GAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKN 202 Query: 329 GHVRISDLGLACDFSKKKPHA----SVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKL 384 ++SDL + + K +GT GY+ P + K D +S G L + Sbjct: 203 WTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGICLLVI 261 Query: 385 LRGHSPFRQHKTKDKHEIDRMTLTM 409 + G D I + + Sbjct: 262 ITGKPAIMTISDGDLQGILSLVREL 286 >4I94-A nrPDB Length = 300 Score = 104 bits (260), Expect = 1e-22, Method: Composition-based stats. Identities = 47/239 (19%), Positives = 83/239 (34%), Gaps = 16/239 (6%) Query: 204 EVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHT 263 VY K + + A+K ++K L E + + + + Sbjct: 44 VVYKG-KLENQRRIAVKRFNRK---SWPDSRQFLEEAKAVGQLRNHRMAN---LLGCCYE 96 Query: 264 PDKLSFILDLMNGGDLHYHLS--QHGVFSEADMRFYAAEIILGLEHMHNRF-VVYRDLKP 320 ++ I + M L HL + A A I LE+ ++ +Y DL Sbjct: 97 DEERLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNA 156 Query: 321 ANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCM 380 +L D+ + R+S GL + K +++ + PE L+ G + +S G + Sbjct: 157 YRVLFDDDANPRLSCFGLMKNSRDGKSYST--NLAFTPPEYLRTGR-VTPESVIYSFGTL 213 Query: 381 LFKLLRGH--SP-FRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRR 436 L LL G P +D++ M + + EL L LQ + R Sbjct: 214 LLDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRER 272 >5UV4-A nrPDB Length = 311 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 45/207 (21%), Positives = 79/207 (38%), Gaps = 20/207 (9%) Query: 195 RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFI 254 IIGR G Y D G M +K L + K K+ + + + P + Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSKK------EFSREIKKLGSVRHPNL 83 Query: 255 VCMSYAFHTPDKLSFIL--DLMNGGDLHYHLSQH-----GVFSEADMRFYAAEIILGLEH 307 V + + P + I+ D + L +LS+ S A +I L++ Sbjct: 84 VPLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDY 143 Query: 308 MHNRFVV-YRDLKPANILL-DEHGHVRISDLGLACDFSKKKPHASV---GTHGYMAPEVL 362 +HN V+ + ++K +N+L+ + ++D L + V G GY PE Sbjct: 144 LHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFS 203 Query: 363 QKGVAY-DSSADWFSLGCMLFKLLRGH 388 +D ++ G +L +LL G Sbjct: 204 STSKPCPSLKSDVYAFGVILLELLTGK 230 >4L68-A nrPDB Length = 340 Score = 98.1 bits (243), Expect = 1e-20, Method: Composition-based stats. Identities = 44/209 (21%), Positives = 77/209 (36%), Gaps = 19/209 (9%) Query: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 N+F+ II G Y G A+K L ++ ++ R ++ + Sbjct: 40 NNFNSENIIVSTRTGTTYKA-LLPDGSALAVKHLSTCKLGEREF-------RYEMNQLWE 91 Query: 249 GDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL-SQHGVFSEADMRFYAAEIILGLEH 307 + + ++ + M+ G LH L S G + GL Sbjct: 92 LRHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAW 151 Query: 308 MH---NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS------VGTHGYMA 358 +H ++++++ + IL+DE RI D GLA + S +G GY+A Sbjct: 152 LHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVA 211 Query: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRG 387 PE + D + LG +L +L G Sbjct: 212 PE-YSTTMLASLKGDVYGLGVVLLELATG 239 >2RSV-A nrPDB Length = 403 Score = 97.0 bits (240), Expect = 3e-20, Method: Composition-based stats. Identities = 53/270 (19%), Positives = 97/270 (35%), Gaps = 34/270 (12%) Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY------AMKCLDKK--------R 226 E+ + ++ V IG+GGFG +Y ++ + +K + Sbjct: 34 EIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELK 92 Query: 227 IKMKQGETLALNERIMLSLVSTGDCP-FIVCMSYAFHTPDKLSFILDLMNGGDLHY-HLS 284 + + + + I + P + + + I+D G DL + + Sbjct: 93 FYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEA 151 Query: 285 QHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD--EHGHVRISDLGLACDF 342 FS + + I+ LE++H V+ D+K +N+LL+ V + D GLA + Sbjct: 152 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 211 Query: 343 SKKKPHASV---------GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQ 393 + H GT + + + GVA D LG + + L GH P+ Sbjct: 212 CPEGVHKEYKEDPKRCHDGTIEFTSIDA-HNGVAPSRRGDLEILGYCMIQWLTGHLPWED 270 Query: 394 HKTKDKHEIDRMTLTMAVE---LPDSFSPE 420 + KD + + L D PE Sbjct: 271 N-LKDPKYVRDSKIRYRENIASLMDKCFPE 299 >2LAV-A nrPDB Length = 361 Score = 97.0 bits (240), Expect = 3e-20, Method: Composition-based stats. Identities = 53/270 (19%), Positives = 97/270 (35%), Gaps = 34/270 (12%) Query: 181 ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMY------AMKCLDKK--------R 226 E+ + ++ V IG+GGFG +Y ++ + +K + Sbjct: 27 EIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELK 85 Query: 227 IKMKQGETLALNERIMLSLVSTGDCP-FIVCMSYAFHTPDKLSFILDLMNGGDLHY-HLS 284 + + + + I + P + + + I+D G DL + + Sbjct: 86 FYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEA 144 Query: 285 QHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD--EHGHVRISDLGLACDF 342 FS + + I+ LE++H V+ D+K +N+LL+ V + D GLA + Sbjct: 145 NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 Query: 343 SKKKPHASV---------GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQ 393 + H GT + + + GVA D LG + + L GH P+ Sbjct: 205 CPEGVHKEYKEDPKRCHDGTIEFTSIDA-HNGVAPSRRGDLEILGYCMIQWLTGHLPWED 263 Query: 394 HKTKDKHEIDRMTLTMAVE---LPDSFSPE 420 + KD + + L D PE Sbjct: 264 N-LKDPKYVRDSKIRYRENIASLMDKCFPE 292 >4O1O-A nrPDB Length = 717 Score = 84.7 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 52/325 (16%), Positives = 106/325 (32%), Gaps = 74/325 (22%) Query: 215 KMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLM 274 + A+K + + +Q + L S+ +V + L L L Sbjct: 370 QEVAVKRFSEGSTRGQQEVSC---------LQSSRANDNVVTFYGSESDGSCLHVCLALC 420 Query: 275 NGGDLHYHLSQHG-----VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHG 329 L HL+ H + R + + + +H ++DL+P NIL+D Sbjct: 421 EY-TLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKN 479 Query: 330 HVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLG-CMLFKLLRGH 388 ++D + +++ D +LG +L+ + +G Sbjct: 480 GTFLADFDKSIKWAEDPQKI---------------------KRDLEALGLLVLYVVKKGD 518 Query: 389 SPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQR--DVNRRLGCLGRGAQE 446 F K + E+ + + PD E R L+ L +V RL Sbjct: 519 ISFETLKNQSFEEVIQGS-------PD---EETRDLIHHLFHPGDNVEDRLSS------- 561 Query: 447 VKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELY 506 + PFF S W+ + +V + ++++ ++LL Sbjct: 562 LLAHPFFWS--WESRYRT---------LRDVGNESDIKTRN---QNSRILQLLQPGT--- 604 Query: 507 RNFPLTISERWQQEVAETVFDTINA 531 + + +W ++ V + +NA Sbjct: 605 SELSTSFA-QWTTKIDSFVMEEMNA 628 >2JII-A nrPDB Length = 352 Score = 76.6 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 37/177 (20%), Positives = 65/177 (36%), Gaps = 16/177 (9%) Query: 256 CMSYAFHTPDKLSFILDLMNGGDLHYHL--SQHGVFSEADMRFYAAEIILGLEHMHNRFV 313 CM + H +L + G L L S V SE + A ++ LE +H Sbjct: 122 CMGFGVHQDKYRFLVLPSL-GRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEY 180 Query: 314 VYRDLKPANILLD--EHGHVRISDLGLACDFSKKKPHASV---------GTHGYMAPEVL 362 V+ ++ NI +D + V ++ G A + H + G +++ + L Sbjct: 181 VHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMD-L 239 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSP 419 KG +D SLG + K L G P+ + + +I + + P Sbjct: 240 HKGCGPSRRSDLQSLGYCMLKWLYGFLPW-TNCLPNTEDIMKQKQKFVDKPGPFVGP 295 >4OAU-C nrPDB Length = 699 Score = 75.8 bits (185), Expect = 7e-14, Method: Composition-based stats. Identities = 54/323 (16%), Positives = 104/323 (32%), Gaps = 69/323 (21%) Query: 214 GKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDL 273 + A+K + + ++ + L S+ + +V + L + L Sbjct: 366 KQEVAVKTFCEGSPRAQREVSC---------LQSSRENSHLVTFYGSESHRGHLFVCVTL 416 Query: 274 MNG---GDLHYHLSQHGVFSEAD-MRFYAAEIILGLEHMH-NRFVVYRDLKPANILLDEH 328 L H + E + R + I ++ +H + ++DL+P NIL+D Sbjct: 417 CEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK 476 Query: 329 GHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLG-CMLFKLLRG 387 ++D K G EV D LG +L+ + +G Sbjct: 477 KAAHLADF--------DKSIKWAGDPQ----EV---------KRDLEDLGRLVLYVVKKG 515 Query: 388 HSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEV 447 F K + E+ +++ PD E + L+ L + R ++ Sbjct: 516 SISFEDLKAQSNEEVVQLS-------PD---EETKDLIHRLFHPGEHVR-----DCLSDL 560 Query: 448 KESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYR 507 PFF W+ + N + DI + E L E + Sbjct: 561 LGHPFFW--TWESRYRTL-----------RNVGNESDIKTRKSESEILRLLQPGPSEHSK 607 Query: 508 NFPLTISERWQQEVAETVFDTIN 530 +F ++W ++ E V +N Sbjct: 608 SF-----DKWTTKINECVMKKMN 625 >4IX6-A nrPDB Length = 350 Score = 73.5 bits (179), Expect = 3e-13, Method: Composition-based stats. Identities = 56/340 (16%), Positives = 99/340 (29%), Gaps = 73/340 (21%) Query: 178 KNVELNIHLTMNDFSVH-RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA 236 K + + D V +G G FG V+ + L + + E L Sbjct: 8 KTLRRTPGVEPKDIRVLPGPLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELL 63 Query: 237 LNERIMLSLVSTGDCPFIVCMSYAFH----TPDKLS--FILD---LM---NGGDLHYHLS 284 E + V ++ + + LM G + L Sbjct: 64 ECEMDVNYHVHANAKGTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALM 123 Query: 285 QHGVFSEADMRFY------------AAEIILGLEHMHNRFVVYRDLKPANILLDEH--GH 330 + G A E++ L +H VV+RD+KPAN++ E G Sbjct: 124 RRGTAPLATAMACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGV 183 Query: 331 VRISDLGLA--CDFSKKKPHASVG----THGYM-APEVLQKGVAYDSSA----------- 372 +++ DLG A C + + G Y A E+ Sbjct: 184 LKLIDLGAAALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAH 243 Query: 373 -----DWFSLGCMLFKLL-------RGHSPFRQHKTKDKHEI--DRMTLTMAVELPDSFS 418 D +S GC++ +L G F +++ R + D + Sbjct: 244 KPDRFDSWSAGCVMLQLAVVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAA 303 Query: 419 PEL-----RSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 + L + L++ + + R C + FF Sbjct: 304 LDANGGAGWDLCQRLMEAERDARASC-----EAALSHAFF 338 >4CI6-B nrPDB Length = 643 Score = 70.8 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 46/283 (16%), Positives = 90/283 (31%), Gaps = 43/283 (15%) Query: 211 ADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYA----FHTPDK 266 D ++ A K + +G A E + G P + + + Sbjct: 66 KDKQRLVA-----KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYY 120 Query: 267 LSFILDLMNG-------GDLHYHLSQHGVFSEA---DMRFYAAEIILGLEHMHNRFVVYR 316 + ++D ++G L Q + SEA ++F A ++ H+ +V+ Sbjct: 121 YALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHN 180 Query: 317 DLKPANILLDE-HGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWF 375 D+KP N++ D G + DLGL S+ T + APE+ + +D F Sbjct: 181 DIKPGNVVFDRASGEPVVIDLGL---HSRSGEQPKGFTESFKAPELGVGNLGASEKSDVF 237 Query: 376 SLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS------------FSPELRS 423 ++ LL G F + ++ R + + D Sbjct: 238 ---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETAYTR 294 Query: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKY 466 + +L + R + E + F ++ Sbjct: 295 FITDILGVSADSR-----PDSNEARLHEFLSDGTIDEESAKQI 332 >6G4J-A nrPDB Length = 315 Score = 70.4 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 35/210 (16%), Positives = 71/210 (33%), Gaps = 32/210 (15%) Query: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 N +++ + +G+G G VY + A+K +E +L Sbjct: 22 KWNGNTYTLRKQLGKGANGIVYLAE--TSDGHVALKV--------SDDSLSITSEVNVLK 71 Query: 245 LVSTGDCPFIVCMSYAFHTPDKLSF----------ILDLMNGGDLHYHLSQHGVFSEADM 294 S V M +F D ++ + G L ++S G + Sbjct: 72 SFSKAQS---VTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGA---EWI 125 Query: 295 RFYAAEIILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDL-GLACDFSKKKPHASVG 352 +++ L +H + ++ DLKP N+++ +R D+ G + K + Sbjct: 126 PVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFY 185 Query: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLF 382 GY + S D F++ ++ Sbjct: 186 DRGY----WGYGTRKAEPSYDLFAVAMIMI 211 >5DMZ-A nrPDB Length = 365 Score = 68.5 bits (166), Expect = 9e-12, Method: Composition-based stats. Identities = 40/220 (18%), Positives = 81/220 (36%), Gaps = 32/220 (14%) Query: 193 VHRIIGRGGFGEVYGCR-----KADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 VH ++G G F +VY A + + +K K + L ER+ S+ Sbjct: 69 VHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKV-QKPANPWEFYIGTQLMERLKPSMQH 127 Query: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEA-----DMRFYAAEII 302 + A + + +L + G L ++ + E + +A ++ Sbjct: 128 MF-----MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRML 182 Query: 303 LGLEHMHNRFVVYRDLKPANILLDE-----------HGHVRISDLGLACDF----SKKKP 347 +E +H+ +++ D+KP N +L + + DLG + D Sbjct: 183 YMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIF 242 Query: 348 HASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRG 387 A T G+ E+L ++ D+F + ++ +L G Sbjct: 243 TAKCETSGFQCVEMLS-NKPWNYQIDYFGVAATVYCMLFG 281 >6EWX-A nrPDB Length = 484 Score = 67.7 bits (164), Expect = 2e-11, Method: Composition-based stats. Identities = 39/199 (19%), Positives = 66/199 (33%), Gaps = 57/199 (28%) Query: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHG--------------------- 329 E + F ++ GLEH+ +++RDL N+LL Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 330 --------------------HVRISDL-------GLACDFSKKKPHASVGTHGYMAPEVL 362 + IS+ G + +KK A +APE++ Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQAR------LAPEIV 322 Query: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELR 422 D F G ++++LL +PF + + R L L +SP L+ Sbjct: 323 SASQY--RKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRREDLPPLPTL-SLYSPGLQ 379 Query: 423 SLLEGLLQRDVNRRLGCLG 441 L LL+ D +R+ Sbjct: 380 QLAHLLLEADPIKRIRIGE 398 >6BHC-A nrPDB Length = 438 Score = 66.2 bits (160), Expect = 5e-11, Method: Composition-based stats. Identities = 37/195 (18%), Positives = 71/195 (36%), Gaps = 29/195 (14%) Query: 279 LHYHLSQHGV---FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL---------- 325 + L+QHG E + ++ GLEH+ V + DL+ N+LL Sbjct: 162 VRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQ 221 Query: 326 -----------DEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADW 374 + +S+ A S + +APE++ D Sbjct: 222 GFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSRLAPEIITATQY--KKCDE 279 Query: 375 FSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVN 434 F G +++++L +PF ++ + E R L + +S L+ L LL + + Sbjct: 280 FQTGILIYEMLHLPNPFDENPELKEREYTRADL-PRIPFRSPYSRGLQQLASCLLNPNPS 338 Query: 435 RRLGCLGRGAQEVKE 449 R+ A+ + + Sbjct: 339 ERILIS--DAKGILQ 351 >6M7Z-A nrPDB Length = 319 Score = 65.8 bits (159), Expect = 6e-11, Method: Composition-based stats. Identities = 37/218 (16%), Positives = 79/218 (36%), Gaps = 43/218 (19%) Query: 267 LSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD 326 L++I ++ G + L S D++ AA ++ L+ +HN +++R ++ + + Sbjct: 121 LTYIFHPLSKGLVGDMLETGR--SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVL 178 Query: 327 EHGHVRISDLGLACDFSKKKPHASVGTHGYM-------APEV--------LQKGVAYDSS 371 G V + L A + T ++ APE+ + Sbjct: 179 PDGTVVLGGLDTAAPIGTE-------TRLWVGFFGQETAPEIDRNFLADLALTQGRHTVK 231 Query: 372 ADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA-VELPDSFSPELRSLLEGLLQ 430 +D +SLG + + + DR + +EL D S +++ Sbjct: 232 SDVYSLGVAF------RNLVQLLGNGNLGPEDRGAVRQDHLELLDKLSQ-------KMIE 278 Query: 431 RDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPP 468 + R +E+ + P F L+++ + K P Sbjct: 279 EEPGNR-----PTIEEIMKDPLFEGLNFEDIEEGKARP 311 >6EAS-A nrPDB Length = 308 Score = 64.2 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 36/248 (14%), Positives = 72/248 (29%), Gaps = 36/248 (14%) Query: 217 YAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKL--SFILDLM 274 A + + K+ E+ + LS VS + + + + Sbjct: 69 VASSLVTSAKDWSKENESQYRKKITNLSKVS---HKNFMNLLGYCEEEHPFTRVMVFEYA 125 Query: 275 NGGDLHYHL--SQHGVFSEADMRFYAAEIILGLEHMHNRFV--VYRDLKPANILLDEHGH 330 G L HL + + I LEHMH R+ + L + Sbjct: 126 PNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFA 185 Query: 331 VRISDLGL---ACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRG 387 ++SDL A + + +P++ Y G +L ++L G Sbjct: 186 AKVSDLEFWNDAKGHNSTTNNELA-----FSPDMEDIVRKY---------GMVLLEILTG 231 Query: 388 HSP----------FRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRL 437 P + + ++ + P+ + L ++ + RD +R Sbjct: 232 RVPSSEDDGPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARALCEVVRSCIDRDPKKRP 291 Query: 438 GCLGRGAQ 445 A+ Sbjct: 292 QMKEVAAR 299 >4AZW-A nrPDB Length = 471 Score = 56.2 bits (134), Expect = 5e-08, Method: Composition-based stats. Identities = 19/132 (14%), Positives = 46/132 (34%), Gaps = 14/132 (10%) Query: 214 GKMYAMKC----LDKKRIKMKQGETLALNERIMLSLVST----GDCPFIVCMSYAFHTPD 265 G+ Y K + + ++ + + ++ D P ++ Sbjct: 259 GEDYVCKFFYYDMPHGILTAEESQRNKHELHNEIKFLTQPPAGFDAPAVLA---HGENAQ 315 Query: 266 KLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL 325 +++ + G L L+ E D ++ L + + + D++P N+++ Sbjct: 316 SGWLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMV 372 Query: 326 DEHGHVRISDLG 337 D H R+ D G Sbjct: 373 DARQHARLIDFG 384 >3BYV-A nrPDB Length = 377 Score = 55.8 bits (133), Expect = 6e-08, Method: Composition-based stats. Identities = 43/248 (17%), Positives = 83/248 (33%), Gaps = 39/248 (15%) Query: 218 AMKCLDKKRIKMK-----QGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLS---- 268 A+K + ++ ++++ + + A + P M + Sbjct: 116 AIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLSR 175 Query: 269 -FILDLMN------GGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPA 321 F+ M G L H S H ++I L +H+ +V+ L+P Sbjct: 176 FFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPV 235 Query: 322 NILLDEHGHVRISDLGLACDFSKKKPH-ASVGTHGYMAPEV------LQKGVA----YDS 370 +I+LD+ G V ++ + S + G+ PE+ + Sbjct: 236 DIVLDQRGGVFLTGF---EHLVRDGARVVSSVSRGFEPPELEARRATISYHRDRRTLMTF 292 Query: 371 SADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSFSPELRSLLEGLL 429 S D ++LG +++ + P + E I R +R+LLEG L Sbjct: 293 SFDAWALGLVIYWIWCADLPITKDAALGGSEWIFRSCKN--------IPQPVRALLEGFL 344 Query: 430 QRDVNRRL 437 + RL Sbjct: 345 RYPKEDRL 352 >4CYJ-A nrPDB Length = 438 Score = 55.8 bits (133), Expect = 7e-08, Method: Composition-based stats. Identities = 29/147 (19%), Positives = 55/147 (37%), Gaps = 26/147 (17%) Query: 205 VYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTP 264 VY + + G+ YA++ L+ R+ ++ ++ IV + F T Sbjct: 71 VYKAQNSRNGRHYALRRLEGYRLTNEKA------ILNVMKDWKKIKNASIVTIHEVFTTR 124 Query: 265 D----KLSFILDLMNGGDLHYHLSQH-------------GVFSEADMRFYAAEIILGLEH 307 + L F D L L +H E + Y +I L+ Sbjct: 125 EFGDSSLIFAYDFHP---LSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKT 181 Query: 308 MHNRFVVYRDLKPANILLDEHGHVRIS 334 +H+ + R L+P+ I+L + +R+S Sbjct: 182 IHSNRLAARCLEPSKIILTDINRIRLS 208 >4AZV-A nrPDB Length = 569 Score = 55.4 bits (132), Expect = 8e-08, Method: Composition-based stats. Identities = 19/132 (14%), Positives = 46/132 (34%), Gaps = 14/132 (10%) Query: 214 GKMYAMKC----LDKKRIKMKQGETLALNERIMLSLVST----GDCPFIVCMSYAFHTPD 265 G+ Y K + + ++ + + ++ D P ++ Sbjct: 259 GEDYVCKFFYYDMPHGILTAEESQRNKYELHNEIKFLTQPPAGFDAPAVLA---HGENAQ 315 Query: 266 KLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL 325 +++ + G L L+ E D ++ L + + + D++P N+++ Sbjct: 316 SGWLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMV 372 Query: 326 DEHGHVRISDLG 337 D H R+ D G Sbjct: 373 DARQHARLIDFG 384 >5GZA-A nrPDB Length = 290 Score = 54.6 bits (130), Expect = 2e-07, Method: Composition-based stats. Identities = 36/215 (16%), Positives = 68/215 (31%), Gaps = 45/215 (20%) Query: 192 SVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDC 251 ++IG+G +VY G+ A+ L + A + LS++ Sbjct: 28 RRVKLIGQGAVKKVYLSEWQ--GQKVALSVLSSDQY--------ADDFLHGLSMLRALQS 77 Query: 252 PFIVCMSYAFHTPDKLSFILDLMNGGD---LHYHLSQHG---VFSEADMRFYAAEIILGL 305 +V + F+ + G L L+Q S A + + L Sbjct: 78 SHVVTLVGVCEEDA--VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFL 135 Query: 306 EHMHN--RFV--------VYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVG--- 352 ++H+ + +++ L + LL + +DL + K G Sbjct: 136 AYLHSSPAGIRVMCDSNDLHKTL--SQFLLASDMRLLANDLDALPEVEKGGLGVKCGHHE 193 Query: 353 -THGYMAPEVL-----------QKGVAYDSSADWF 375 T ++APE L + YD D + Sbjct: 194 LTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >3ENH-A nrPDB Length = 540 Score = 52.3 bits (124), Expect = 7e-07, Method: Composition-based stats. Identities = 29/164 (17%), Positives = 57/164 (34%), Gaps = 24/164 (14%) Query: 194 HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK-----RIKMKQGETLALNERIMLSLVST 248 +IG+G ++ R + +K KK R+ ++ E L+LV Sbjct: 341 EHLIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKD 398 Query: 249 GDCP--FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLE 306 P +I + ++ +NG + + A +I + Sbjct: 399 FGIPAPYI---FDVDLDNKR--IMMSYINGKLAKDVIEDN--------LDIAYKIGEIVG 445 Query: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS 350 +H V++ DL +N + D+ + I D GL + + A Sbjct: 446 KLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDEDKAV 487 >4WWA-A nrPDB Length = 261 Score = 51.5 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 30/152 (19%), Positives = 53/152 (34%), Gaps = 23/152 (15%) Query: 206 YGCRKADTGKMYAMKCLDKKRIKMKQGETLA-----LNERIMLSLVSTGDCPFIVCMSYA 260 Y R D+ + Y +K KR + Q + LNE +L+ + + + Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Query: 261 FHTPDKLSFIL--DLMNGG----DLHYHL--SQHGVFSE---ADMRFYAAEIILGLEHMH 309 + + + GG +L L +S+ +R +I L +H Sbjct: 98 DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGL----LH 153 Query: 310 NRFVVYRDLKPANILLDEHG---HVRISDLGL 338 + DL +NI+L G + D GL Sbjct: 154 WNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >3DZO-A nrPDB Length = 413 Score = 51.1 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 43/247 (17%), Positives = 84/247 (34%), Gaps = 38/247 (15%) Query: 218 AMKCLDKKRIKMK-----QGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLS---- 268 A+K + ++ ++++ + + A + P M + Sbjct: 121 AIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLSR 180 Query: 269 -FILDLMN------GGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPA 321 F+ M G L H S H ++I L +H+ +V+ L+P Sbjct: 181 FFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPV 240 Query: 322 NILLDEHGHVRISDLGLACDFSKKKPHAS--VGTHGYMAPE-----VLQKGVAY----DS 370 +I+LD+ G V ++ + A +G G+ PE +L G + Sbjct: 241 DIVLDQRGGVFLTGF---EHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTF 296 Query: 371 SADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQ 430 + D ++LG ++ + P D + + +R+LLEG L+ Sbjct: 297 AFDTWTLGLAIYWIWCADLP-----NTDDAALGGSEWIFRS--CKNIPQPVRALLEGFLR 349 Query: 431 RDVNRRL 437 RL Sbjct: 350 YPKEDRL 356 >5VE6-A nrPDB Length = 492 Score = 50.0 bits (118), Expect = 4e-06, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 20/35 (57%) Query: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL 325 E + F ++ GLEH+ +++RDL N+LL Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 45.8 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 20/85 (23%), Positives = 36/85 (42%), Gaps = 3/85 (3%) Query: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDS 416 +APE++ D F G ++++LL +PF + + + L L Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRQEDLPPLPAL-SL 381 Query: 417 FSPELRSLLEGLLQRDVNRRLGCLG 441 +SP L+ L LL+ D +R+ Sbjct: 382 YSPGLQQLAHLLLEADPIKRIRIGE 406 >2W1Z-A nrPDB Length = 368 Score = 49.6 bits (117), Expect = 4e-06, Method: Composition-based stats. Identities = 46/302 (15%), Positives = 91/302 (30%), Gaps = 67/302 (22%) Query: 191 FSVHRIIGR--------------GGFGEVYGCRKADTGK--MY------------AMKCL 222 F V +G G + +TG+ A+K L Sbjct: 47 FRVESELGERPRTLVRGPVLRDDGSY-ICLEATDQETGEPLEVHVPYFTERPPSNAIKQL 105 Query: 223 DKKRIKMK-----QGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDL---- 273 ++ ++++ + + A + + P M + + Sbjct: 106 SEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVLSRFFLYP 165 Query: 274 -------MNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD 326 + G L H S H ++I + + +V+ D + NILLD Sbjct: 166 RMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLD 225 Query: 327 EHGHVRISDLGLACDFSKKKPHAS--VGTHGYMAPE-----VLQKGVAY----DSSADWF 375 + G V ++ + A +G G+ PE +L + D + Sbjct: 226 QRGGVFLTGF---EHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTW 281 Query: 376 SLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNR 435 +LG ++ + P + E+ + + +R+LLEG L+ Sbjct: 282 TLGLAIYWIWCADLP-----NTEDAELGGIEWI--YRRCKNIPQPVRALLEGFLRYSKED 334 Query: 436 RL 437 RL Sbjct: 335 RL 336 >3Q60-A nrPDB Length = 371 Score = 49.2 bits (116), Expect = 6e-06, Method: Composition-based stats. Identities = 35/169 (20%), Positives = 64/169 (37%), Gaps = 23/169 (13%) Query: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGY 356 A++I ++ ++ +V+ P N+ + G + + D+ + P +SV Sbjct: 199 LTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGDVSALWKVGTRGPASSV--PVT 256 Query: 357 MAP-EVLQKGV-AYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA---- 410 AP E L + + + + LG ++++ PF K R +L + Sbjct: 257 YAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFGLVTPGIKGSWKRPSLRVPGTDS 316 Query: 411 ------VELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 LPD ++L+ L D RRL L E E+P F Sbjct: 317 LAFGSCTPLPDFV----KTLIGRFLNFDRRRRLLPL-----EAMETPEF 356 >4CZY-B nrPDB Length = 429 Score = 48.4 bits (114), Expect = 9e-06, Method: Composition-based stats. Identities = 26/144 (18%), Positives = 52/144 (36%), Gaps = 22/144 (15%) Query: 206 YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTP- 264 Y + G+ +A++ ++ R+ ++ + IV + AF T Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKA------ILNVTKEWKKIINANIVTVHEAFTTEF 114 Query: 265 ---DKLSFILDLMNGGD-LHYH----------LSQHGVFSEADMRFYAAEIILGLEHMHN 310 L F+ D + L+ H L E + Y +I L +HN Sbjct: 115 FGDSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHN 174 Query: 311 RFVVYRDLKPANILLDEHGHVRIS 334 + R L+ + I + E+ +R++ Sbjct: 175 AKLAARCLELSKI-IWENNRIRLA 197 >6G38-A nrPDB Length = 357 Score = 46.1 bits (108), Expect = 5e-05, Method: Composition-based stats. Identities = 31/181 (17%), Positives = 52/181 (28%), Gaps = 47/181 (25%) Query: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSL 245 L IG G FGEV+ T A+K + + + G E I+ + Sbjct: 38 LPTEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQKTFEEILPEI 95 Query: 246 VST-------------------GDCPFIVCMSY----------------------AFHTP 264 + + + V SY F Sbjct: 96 IISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKD 155 Query: 265 DKLSFILDLMNGG-DLHYHLSQHGVFSEADMRFYAAEIILGLEHMH-NRFVVYRDLKPAN 322 D+L +L+ GG DL ++ A + ++ L + +RDL N Sbjct: 156 DQLFIVLEFEFGGIDLEQMRTKLSSL--ATAKSILHQLTASLAVAEASLRFEHRDLHWGN 213 Query: 323 I 323 + Sbjct: 214 V 214 >5GZ9-A nrPDB Length = 305 Score = 45.8 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 30/215 (13%), Positives = 63/215 (29%), Gaps = 44/215 (20%) Query: 192 SVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDC 251 + +G G V+ + A+ L R++MK+ L ++ + Sbjct: 37 RQLKRVGEGAVKRVFLSEWKE--HKVALSRL--TRLEMKEDFLHGL------QMLKSLQS 86 Query: 252 PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNR 311 +V + + + G L + D+ + + L +E++ Sbjct: 87 EHVVTLVGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSII 144 Query: 312 FVVYR------------DLKPANI---LLDEHGHVRISDL-GLACDFSKKKPHASVGTHG 355 ++ DL P + LL + + +DL L G Sbjct: 145 NYLHHSPLGTRVMCDSNDL-PKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRE 203 Query: 356 ----YMAPEVL-----------QKGVAYDSSADWF 375 ++APE L +Y+ D + Sbjct: 204 LHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >2EBZ-A nrPDB Length = 155 Score = 44.6 bits (104), Expect = 2e-04, Method: Composition-based stats. Identities = 23/120 (19%), Positives = 54/120 (45%), Gaps = 8/120 (6%) Query: 51 GEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEER--LVCSREI 108 V+FE++ +G F DF K E + F++ + + + +++ +REI Sbjct: 15 WAVSFERLLQDPVGVRYFSDFLRKEFSEEN--ILFWQACEYFNHVPAHDKKELSYRAREI 72 Query: 109 FDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIES 168 F ++ + + S++ + V + PD+F+ +I ++ D + +F++S Sbjct: 73 FSKFLCSKATTPVNIDSQAQLAD----DVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKS 128 >1TQM-A nrPDB Length = 282 Score = 43.4 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 36/190 (18%), Positives = 70/190 (36%), Gaps = 42/190 (22%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKC-------LDKKRIKMKQGE--------TLAL 237 + +++G G V+ C G+ +K K + K G+ A Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECV-VKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSAR 152 Query: 238 NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFY 297 NE L + P + YA+ + +++L++ +L+ ++ + + Sbjct: 153 NEFRALQKLQGLAVPKV----YAWEGN---AVLMELIDAKELYRVRVEN---PDEVLDMI 202 Query: 298 AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYM 357 E+ H R +V+ DL N+L+ E G + I D VG G+ Sbjct: 203 LEEVAK---FYH-RGIVHGDLSQYNVLVSEEG-IWIIDF---------PQSVEVGEEGWR 248 Query: 358 APEVLQKGVA 367 E+L++ V Sbjct: 249 --EILERDVR 256 >2JNU-A nrPDB Length = 154 Score = 41.5 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 22/120 (18%), Positives = 58/120 (48%), Gaps = 8/120 (6%) Query: 51 GEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEER--LVCSREI 108 ++FE++ LG F +F K E + V F++ ++++++ + + +R I Sbjct: 11 WALSFERLLQDPLGLAYFTEFLKK--EFSAENVTFWKACERFQQIPASDTQQLAQEARNI 68 Query: 109 FDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIES 168 + ++ + L+ + ++ + G V + PD+F+ +I ++ D + +F++S Sbjct: 69 YQEFLSSQALSPVNIDRQAWL----GEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKS 124 >1DK8-A nrPDB Length = 147 Score = 41.5 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 6/115 (5%) Query: 64 GYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLET----EEERLVCSREIFDTYIMKELLA 119 G LFR F + E L++F+ + KLE EE+RL +R I+ YI+ Sbjct: 25 GISLFRTFLKQ--EGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGI 82 Query: 120 CSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRF 174 S + ++G ++K+ + P +F EI + + + F++SD + + Sbjct: 83 VSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 137 >1EMU-A nrPDB Length = 132 Score = 40.7 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 6/115 (5%) Query: 64 GYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLET----EEERLVCSREIFDTYIMKELLA 119 G LFR F + E L++F+ + KLE EE+RL +R I+ YI+ Sbjct: 19 GISLFRTFLKQ--EGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGI 76 Query: 120 CSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRF 174 S + ++G ++K+ + P +F EI + + + F++SD + + Sbjct: 77 VSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 131 >4OTP-A nrPDB Length = 352 Score = 40.7 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 32/177 (18%), Positives = 63/177 (35%), Gaps = 23/177 (12%) Query: 192 SVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE------------ 239 ++ I G VY G+ A+K + K + E Sbjct: 39 EINGCISTGKEANVYHA-STANGESRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNP 97 Query: 240 RIMLSLVSTGDCPFIVCMSYA-FHTPDKLSF-----ILDLMNGGDLHYHLSQHGVFSEAD 293 R M+ + + ++ ++ A P+ + ++ + D+ L ++ SE+ Sbjct: 98 RKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESK 157 Query: 294 MRFYAAEIILGLEHM-HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA 349 R ++I + M + +V+ DL N+L G V I D ++ PHA Sbjct: 158 ARELYLQVIQYMRRMYQDARLVHADLSEFNMLY-HGGGVYIID--VSQSVEHDHPHA 211 >6G5I-z nrPDB Length = 568 Score = 40.0 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 32/177 (18%), Positives = 63/177 (35%), Gaps = 23/177 (12%) Query: 192 SVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE------------ 239 ++ I G VY G+ A+K + K + E Sbjct: 181 EINGCISTGKEANVYHA-STANGESRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNP 239 Query: 240 RIMLSLVSTGDCPFIVCMSYA-FHTPDKLSF-----ILDLMNGGDLHYHLSQHGVFSEAD 293 R M+ + + ++ ++ A P+ + ++ + D+ L ++ SE+ Sbjct: 240 RKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESK 299 Query: 294 MRFYAAEIILGLEHM-HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA 349 R ++I + M + +V+ DL N+L G V I D ++ PHA Sbjct: 300 ARELYLQVIQYMRRMYQDARLVHADLSEFNMLY-HGGGVYIID--VSQSVEHDHPHA 353 >5YK0-A nrPDB Length = 452 Score = 38.8 bits (89), Expect = 0.009, Method: Composition-based stats. Identities = 28/169 (16%), Positives = 51/169 (30%), Gaps = 37/169 (21%) Query: 203 GEVYGCRKADTGKMYAMKC--------LDKKRIKMK---------------QGETLALNE 239 G+V+ +D G+ A+K L M+ QG L E Sbjct: 146 GQVHKAIWSD-GREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKL-----------SFILDLMNGGDLHYHLSQHGV 288 R + L + + A+H + I + + G + + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTT 264 Query: 289 FSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLG 337 + AE+ + +++ D P N +L G + I D G Sbjct: 265 EQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >1EZY-A nrPDB Length = 166 Score = 37.7 bits (86), Expect = 0.018, Method: Composition-based stats. Identities = 22/134 (16%), Positives = 59/134 (44%), Gaps = 6/134 (4%) Query: 41 SVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEE 100 SV Q+ ++ E E + + + G F+ F E ++F+ ++Y+K+++ + Sbjct: 4 SVSQEEVKKWAESL-ENLINHECGLAAFKAFLKSEYSEEN--IDFWISCEEYKKIKSPSK 60 Query: 101 RLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGD 160 +++I++ +I + + S + E + L + F ++I + D Sbjct: 61 LSPKAKKIYNEFISVQATKEVNLDSCTREETSRNML---EPTITCFDEAQKKIFNLMEKD 117 Query: 161 VFQKFIESDKFTRF 174 +++F++S + Sbjct: 118 SYRRFLKSRFYLDL 131 >1AGR-E nrPDB Length = 205 Score = 37.7 bits (86), Expect = 0.020, Method: Composition-based stats. Identities = 21/150 (14%), Positives = 62/150 (41%), Gaps = 11/150 (7%) Query: 22 ATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKP 81 ++ ++ K + S V + + E + + + G F+ F E Sbjct: 36 SSSHSKKDKVVTCQRVSQEEV------KKWAESLENLINHECGLAAFKAFLKSEYSEEN- 88 Query: 82 LVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQV 141 ++F+ ++Y+K+++ + +++I++ +I + + S + E + L + Sbjct: 89 -IDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNML---EP 144 Query: 142 PPDLFQPYIEEICQNLRGDVFQKFIESDKF 171 F ++I + D +++F++S + Sbjct: 145 TITCFDEAQKKIFNLMEKDSYRRFLKSRFY 174 >6FDN-A nrPDB Length = 320 Score = 36.5 bits (83), Expect = 0.039, Method: Composition-based stats. Identities = 15/74 (20%), Positives = 32/74 (43%), Gaps = 6/74 (8%) Query: 263 TPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPAN 322 ++ + +++L+NG L S D E + + + N +++ D N Sbjct: 180 DYNRHAVVMELINGYPLCQIHHVEDPASVYD------EAMELIVKLANHGLIHGDFNEFN 233 Query: 323 ILLDEHGHVRISDL 336 ++LDE H+ + D Sbjct: 234 LILDESDHITMIDF 247 >6G18-v nrPDB Length = 552 Score = 36.1 bits (82), Expect = 0.049, Method: Composition-based stats. Identities = 15/74 (20%), Positives = 32/74 (43%), Gaps = 6/74 (8%) Query: 263 TPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPAN 322 ++ + +++L+NG L S D E + + + N +++ D N Sbjct: 180 DYNRHAVVMELINGYPLCQIHHVEDPASVYD------EAMELIVKLANHGLIHGDFNEFN 233 Query: 323 ILLDEHGHVRISDL 336 ++LDE H+ + D Sbjct: 234 LILDESDHITMIDF 247 >3IF8-A nrPDB Length = 339 Score = 35.0 bits (79), Expect = 0.10, Method: Composition-based stats. Identities = 18/100 (18%), Positives = 37/100 (37%), Gaps = 9/100 (9%) Query: 413 LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPP-PLI 471 + + + LLQ+ + +++ PF D Q+ + K P PL Sbjct: 6 MWERLNCAAEDFYSRLLQK--------FNEEKKGIRKDPFLYEADVQVQLISKGQPNPLK 57 Query: 472 PPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL 511 E + + ++E+T I+ L S++ +F Sbjct: 58 NILNENDIVFIVEKVPLEKEETSHIEELQSEETAISDFST 97 >4BVU-A nrPDB Length = 211 Score = 34.2 bits (77), Expect = 0.20, Method: Composition-based stats. Identities = 21/145 (14%), Positives = 46/145 (31%), Gaps = 16/145 (11%) Query: 193 VHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCP 252 + ++IG+G E++ + K D + + +A E + + GD Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY---KKYDLIGNQYNEILEMAWQESELFNAF-YGDEA 99 Query: 253 FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF 312 +V + + + G L + Y I ++ Sbjct: 100 SVVIQYG-----GDVYLRMLRVPGTPLSDI--DTADIPDNIESLYLQLICK----LNELS 148 Query: 313 VVYRDLKPANILLDEHGH-VRISDL 336 +++ DL N+L D+ + D Sbjct: 149 IIHYDLNTGNMLYDKESESLFPIDF 173 >6FAI-l nrPDB Length = 425 Score = 33.8 bits (76), Expect = 0.27, Method: Composition-based stats. Identities = 27/181 (14%), Positives = 61/181 (33%), Gaps = 29/181 (16%) Query: 178 KNVELNIHLTMND-FSVHRIIGRGGFGEVYGCRKADTGKMYAMKC--LDKKRIKMKQGET 234 + L L + +SV IG G ++Y + MK L + + Sbjct: 81 DYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNR 139 Query: 235 LALNER------IMLSLVSTGDCPFIVCMSYA--FHTPDKL-----SFILDLMNGGDLHY 281 L + + LS ++ + M Y+ F P+ +++L+ G + Sbjct: 140 DYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMR- 198 Query: 282 HLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILL------DEHGHVRISD 335 L +H ++++ + + N +++ D NI++ + + D Sbjct: 199 RLRKHKNIP-----KLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVID 253 Query: 336 L 336 Sbjct: 254 F 254 >1WI1-A nrPDB Length = 126 Score = 32.3 bits (72), Expect = 0.72, Method: Composition-based stats. Identities = 25/119 (21%), Positives = 51/119 (42%), Gaps = 16/119 (13%) Query: 563 GYMSKMGNPFLTQWQRRYF-------YLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQ-- 613 GY+ +G +W++R+F Y F +R + PQ LL ++ +V+ T Sbjct: 12 GYLWAIGKNVWKRWKKRFFVLVQVSQYTFA-MCSYREKKAEPQELLQLDGY-TVDYTDPQ 69 Query: 614 --IKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRS 670 ++ + ++ G + D + + + W + + YR Q + VP ++ P S Sbjct: 70 PGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAM---YRATGQSHKPVPPTQSGPSS 125 >4B68-A nrPDB Length = 501 Score = 32.3 bits (72), Expect = 0.74, Method: Composition-based stats. Identities = 17/50 (34%), Positives = 25/50 (50%), Gaps = 3/50 (6%) Query: 564 YMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQ 613 Y+ ++ NP TQWQ R + P R R E PQS + + S E++ Sbjct: 340 YLQRVKNPDETQWQHR---ILPERKITRVEHHGPQSRMRIHLKSSKPESE 386 >6HA8-c nrPDB Length = 218 Score = 31.9 bits (71), Expect = 0.98, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 37/89 (41%), Gaps = 4/89 (4%) Query: 147 QPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEV- 205 + Y + + ++L+ + SD + + +++T++ +IG+GG EV Sbjct: 26 KDYADFLHEDLKIREYISKRLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGG-SEVE 84 Query: 206 --YGCRKADTGKMYAMKCLDKKRIKMKQG 232 + TGK + L+ KR + Sbjct: 85 ALRKALNSLTGKRVHINILEIKRADLDAQ 113 >3D1Q-A nrPDB Length = 340 Score = 31.9 bits (71), Expect = 1.1, Method: Composition-based stats. Identities = 25/115 (21%), Positives = 41/115 (35%), Gaps = 27/115 (23%) Query: 121 SHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV 180 S F+ + +++V L +K P +E L G + E D W N+ Sbjct: 99 SSAFTPAQLKNVAAKLREKTAGPIYDVDLRQESHGYLDGIPVSWYGERD-------WANL 151 Query: 181 ELNIHLTMNDFSVHRI------------IGR-----GGFGEVYGCRKADTGKMYA 218 + H + D HR+ +G+ G GEV +K T + A Sbjct: 152 GKSQHEALAD-ERHRLHAALHKTVYIAPLGKHKLPEG--GEVRRVQKVQTEQEVA 203 >6EF6-A nrPDB Length = 354 Score = 31.1 bits (69), Expect = 1.9, Method: Composition-based stats. Identities = 7/28 (25%), Positives = 15/28 (53%), Gaps = 3/28 (10%) Query: 312 FVVYRDLKPANILLDEHG---HVRISDL 336 +++ DL+ AN+L+D + + D Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >1DRO-A nrPDB Length = 122 Score = 30.3 bits (67), Expect = 2.6, Method: Composition-based stats. Identities = 19/61 (31%), Positives = 29/61 (47%), Gaps = 4/61 (6%) Query: 588 LEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKEL 647 L +RGE P L I+ + K++ L +K+ G F+LQ D E+ QW L Sbjct: 59 LTFRGE---PSYDLQNAAIE-IASDYTKKKHVLRVKLANGALFLLQAHDDTEMSQWVTSL 114 Query: 648 R 648 + Sbjct: 115 K 115 >3CX6-B nrPDB Length = 203 Score = 30.3 bits (67), Expect = 2.7, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 53/150 (35%), Gaps = 32/150 (21%) Query: 56 EKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMK 115 EK+ S ++F + L + PL+ FY + Y++ ++ R + ++I++ ++ K Sbjct: 27 EKLKSHPAYLVVFLRYILSQA-DPGPLL-FYLCSEVYQQTNPKDSRSL-GKDIWNIFLEK 83 Query: 116 ELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFC 175 + + L + P ++ E + Sbjct: 84 NAPLRV-KIPEMLQAEIDLRLRNNEDPRNVLCEAQEAVM--------------------- 121 Query: 176 QWKNVELNIHLTMNDFSVHRIIGRGG-FGE 204 L I +ND+ R +G G +GE Sbjct: 122 ------LEIQEQINDYRSKRTLGLGSLYGE 145 >4GYG-A nrPDB Length = 397 Score = 30.3 bits (67), Expect = 3.0, Method: Composition-based stats. Identities = 32/200 (16%), Positives = 61/200 (30%), Gaps = 32/200 (16%) Query: 162 FQKFIESDKFTRFCQWKNVELNIHLTMND-FSVHRIIGRGGFGEVYGCRKADTGKMYAMK 220 ++ + + L+ H D +SV IG G ++ GK +K Sbjct: 67 MKEAKYDGYRLTYGGLDYLALHTHAARKDVYSVGSRIGVGKESDIMIVADEK-GKQKVLK 125 Query: 221 C--LDKKRIKMKQGETLALNER-----IMLSLVSTGDCPFIVC--MSYAFHTPDKLS--- 268 L + + + L R + LS ++ + F P+ ++ Sbjct: 126 IHRLGRISFRTVKANRDYLRNRSTGSWMYLSRLAAIKEFAFMKALYEEGFPVPEPIAQSR 185 Query: 269 --FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLD 326 ++ L L V S D A++I + + +++ D NIL+ Sbjct: 186 HTIVM------SLVDALPMRQVSSVPDPASLYADLIALILRLAKHGLIHGDFNEFNILIR 239 Query: 327 EHGHVR----------ISDL 336 E I D Sbjct: 240 EEKDAEDPSSITLTPIIIDF 259 >5JPZ-A nrPDB Length = 509 Score = 30.3 bits (67), Expect = 3.1, Method: Composition-based stats. Identities = 14/108 (12%), Positives = 41/108 (37%), Gaps = 7/108 (6%) Query: 83 VEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVP 142 + +E +++E E RL +F +L + + E+ + +P Sbjct: 160 LALWEAYREFESAIVEAARLEKVHSLFRR----QLAIPLYDMEATFAEY--EEWSEDPIP 213 Query: 143 PDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMND 190 + Q Y + + Q + +++ + + R ++ ++ + + D Sbjct: 214 ESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEY-QAYIDFEMKIGD 260 >2ZCW-A nrPDB Length = 202 Score = 30.0 bits (66), Expect = 3.3, Method: Composition-based stats. Identities = 16/51 (31%), Positives = 31/51 (60%), Gaps = 7/51 (13%) Query: 635 DSDPELVQ-----WKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPL 680 + DPEL++ + L +AYR ++L + ++KN+ + ++ELS+ PL Sbjct: 87 NPDPELLKDLAQHLSQGLAEAYRRIERLATQ--RLKNRMAAALLELSETPL 135 >5CTQ-A nrPDB Length = 561 Score = 30.0 bits (66), Expect = 3.7, Method: Composition-based stats. Identities = 14/108 (12%), Positives = 41/108 (37%), Gaps = 7/108 (6%) Query: 83 VEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVP 142 + +E +++E E RL +F +L + + E+ + +P Sbjct: 175 LALWEAYREFESAIVEAARLEKVHSLFRR----QLAIPLYDMEATFAEY--EEWSEDPIP 228 Query: 143 PDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMND 190 + Q Y + + Q + +++ + + R ++ ++ + + D Sbjct: 229 ESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEY-QAYIDFEMKIGD 275 >4BFR-A nrPDB Length = 952 Score = 30.0 bits (66), Expect = 3.8, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 34/79 (43%), Gaps = 13/79 (16%) Query: 260 AFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLK 319 AF+ L+++ + +G DL + + F+ + + A +LG+ H+ Sbjct: 757 AFNKDALLNWLKEYNSGDDLDRAIEE---FTLSCAGYCVASYVLGIGDRHS--------- 804 Query: 320 PANILLDEHGHVRISDLGL 338 NI++ + G + D G Sbjct: 805 -DNIMVKKTGQLFHIDFGH 822 >5JJX-A nrPDB Length = 314 Score = 30.0 bits (66), Expect = 3.8, Method: Composition-based stats. Identities = 14/108 (12%), Positives = 41/108 (37%), Gaps = 7/108 (6%) Query: 83 VEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVP 142 + +E +++E E RL +F +L + + E+ + +P Sbjct: 146 LALWEAYREFESAIVEAARLEKVHSLFRR----QLAIPLYDMEATFAEY--EEWSEDPIP 199 Query: 143 PDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMND 190 + Q Y + + Q + +++ + + R ++ ++ + + D Sbjct: 200 ESVIQNYNKALQQLEKYKPYEEALLQAEAPRLAEY-QAYIDFEMKIGD 246 >5FIR-A nrPDB Length = 636 Score = 30.0 bits (66), Expect = 3.9, Method: Composition-based stats. Identities = 12/58 (20%), Positives = 23/58 (39%), Gaps = 4/58 (6%) Query: 470 LIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLT----ISERWQQEVAE 523 P A+D +G F + T+ K + ++L FP + WQ+ + + Sbjct: 438 YFPYHYAPFASDFETVGEFQPDFTRPTKPFNPLEQLMSVFPAASKQHLPVEWQKLMIQ 495 >1QQG-A nrPDB Length = 264 Score = 30.0 bits (66), Expect = 4.0, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 32/72 (44%) Query: 584 FPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQW 643 + N +WR + AP+ + +E ++ + + K L+ + F + DS+ E W Sbjct: 44 YENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSW 103 Query: 644 KKELRDAYREAQ 655 + L + A+ Sbjct: 104 YQALLQLHNRAK 115 >6GL3-A nrPDB Length = 386 Score = 28.8 bits (63), Expect = 7.6, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 25/66 (37%), Gaps = 10/66 (15%) Query: 279 LHYHLSQHGVFSEA---DMRFYAAEIILG---LEHMHNRFVVYRDLKPANILLDEHGHVR 332 L Y L +HG ++ + + G + ++ + NILLD GH+ Sbjct: 219 LDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHN----GNILLDAEGHII 274 Query: 333 ISDLGL 338 D G Sbjct: 275 HIDFGF 280 >4D0L-A nrPDB Length = 566 Score = 28.8 bits (63), Expect = 8.4, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 25/66 (37%), Gaps = 10/66 (15%) Query: 279 LHYHLSQHGVFSEA---DMRFYAAEIILG---LEHMHNRFVVYRDLKPANILLDEHGHVR 332 L Y L +HG ++ + + G + ++ + NILLD GH+ Sbjct: 398 LDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHN----GNILLDAEGHII 453 Query: 333 ISDLGL 338 D G Sbjct: 454 HIDFGF 459 >5C4G-E nrPDB Length = 529 Score = 28.8 bits (63), Expect = 8.5, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 25/66 (37%), Gaps = 10/66 (15%) Query: 279 LHYHLSQHGVFSEA---DMRFYAAEIILG---LEHMHNRFVVYRDLKPANILLDEHGHVR 332 L Y L +HG ++ + + G + ++ + NILLD GH+ Sbjct: 361 LDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHN----GNILLDAEGHII 416 Query: 333 ISDLGL 338 D G Sbjct: 417 HIDFGF 422 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.141 0.411 Lambda K H 0.267 0.0430 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 28,313,593 Number of Sequences: 36641 Number of extensions: 1231658 Number of successful extensions: 7293 Number of sequences better than 10.0: 528 Number of HSP's better than 10.0 without gapping: 897 Number of HSP's successfully gapped in prelim test: 99 Number of HSP's that attempted gapping in prelim test: 3338 Number of HSP's gapped (non-prelim): 1128 length of query: 689 length of database: 10,336,785 effective HSP length: 104 effective length of query: 585 effective length of database: 6,526,121 effective search space: 3817780785 effective search space used: 3817780785 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 63 (28.8 bits)