BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P20815 (502 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5VEU-A nrPDB 976 0.0 6DA2-A nrPDB 853 0.0 6C94-A nrPDB 160 9e-40 4R20-A nrPDB 147 9e-36 3K9V-A nrPDB 138 4e-33 4KPA-A nrPDB 138 6e-33 3MDV-A nrPDB 137 1e-32 4H1N-A nrPDB 135 4e-32 5YLW-A nrPDB 132 2e-31 5W0C-A nrPDB 124 9e-29 1N6B-A nrPDB 119 4e-27 3DL9-A nrPDB 117 2e-26 4GQS-A nrPDB 116 2e-26 5E58-A nrPDB 115 4e-26 3QZ1-A nrPDB 115 4e-26 2PG7-A nrPDB 115 5e-26 2NNH-A nrPDB 114 1e-25 5UYS-A nrPDB 114 1e-25 5E0E-A nrPDB 113 2e-25 2VE3-A nrPDB 110 1e-24 6DWN-A nrPDB 108 6e-24 4R1Z-A nrPDB 108 8e-24 5VBU-A nrPDB 107 8e-24 2HI4-A nrPDB 107 9e-24 3IBD-A nrPDB 105 5e-23 3E6I-A nrPDB 105 6e-23 6B82-A nrPDB 105 7e-23 3N9Z-A nrPDB 101 7e-22 2W0A-A nrPDB 100 2e-21 3MZS-A nrPDB 98 9e-21 6AYB-A nrPDB 97 2e-20 3TBG-A nrPDB 95 7e-20 6M7X-A nrPDB 94 1e-19 4ZGX-A nrPDB 92 4e-19 3EL3-A nrPDB 87 1e-17 3JUS-A nrPDB 87 1e-17 6IQ5-A nrPDB 87 2e-17 3S79-A nrPDB 84 2e-16 2WX2-A nrPDB 77 2e-14 6B11-A nrPDB 76 4e-14 3L4D-A nrPDB 75 7e-14 2X2N-A nrPDB 73 3e-13 3P3Z-A nrPDB 73 3e-13 6CR2-A nrPDB 73 4e-13 4WMZ-A nrPDB 69 4e-12 5JLC-A nrPDB 69 4e-12 4OQR-A nrPDB 69 5e-12 1Z8P-A nrPDB 69 5e-12 2Z36-A nrPDB 68 9e-12 4OQS-A nrPDB 67 2e-11 1WIY-A nrPDB 67 2e-11 5XNT-A nrPDB 67 3e-11 4YT3-A nrPDB 65 6e-11 5L94-A nrPDB 65 9e-11 4GGV-A nrPDB 65 9e-11 3AWQ-A nrPDB 64 1e-10 5CJE-A nrPDB 64 2e-10 3OFT-A nrPDB 63 3e-10 2VZM-A nrPDB 62 4e-10 4UBS-A nrPDB 62 5e-10 4Z5P-A nrPDB 62 6e-10 5FSA-A nrPDB 61 1e-09 2ZQJ-A nrPDB 61 1e-09 4RM4-A nrPDB 61 1e-09 3ABB-A nrPDB 61 1e-09 5VWS-A nrPDB 60 2e-09 3A50-A nrPDB 60 2e-09 3BUJ-A nrPDB 60 2e-09 5OFQ-A nrPDB 60 2e-09 6DCD-A nrPDB 60 3e-09 1Q5D-A nrPDB 59 4e-09 5KYO-A nrPDB 59 4e-09 5YHJ-A nrPDB 59 4e-09 5NWS-A nrPDB 59 4e-09 6FYJ-A nrPDB 59 4e-09 5HDI-A nrPDB 59 6e-09 3NV6-A nrPDB 59 7e-09 3EJB-B nrPDB 59 7e-09 4JBT-A nrPDB 58 8e-09 5YSW-A nrPDB 58 1e-08 3SN5-A nrPDB 57 1e-08 2WIO-A nrPDB 57 2e-08 6A7I-A nrPDB 57 3e-08 5XJN-A nrPDB 56 3e-08 3TKT-A nrPDB 56 3e-08 5M0P-A nrPDB 56 3e-08 4MM0-A nrPDB 56 3e-08 3TYW-A nrPDB 56 3e-08 5GWE-A nrPDB 56 4e-08 1UE8-A nrPDB 56 5e-08 6F0B-A nrPDB 55 5e-08 3MGX-A nrPDB 55 5e-08 5FOI-A nrPDB 55 6e-08 6HQG-A nrPDB 55 8e-08 3WVS-A nrPDB 55 9e-08 2Y5N-A nrPDB 54 1e-07 4TRI-A nrPDB 54 1e-07 6GK6-A nrPDB 54 1e-07 5LIV-A nrPDB 54 2e-07 3ABA-A nrPDB 54 2e-07 1GWI-A nrPDB 54 2e-07 2XKR-A nrPDB 53 2e-07 3RWL-A nrPDB 53 3e-07 5FYF-A nrPDB 53 3e-07 6F88-A nrPDB 53 3e-07 6A7J-A nrPDB 53 4e-07 6HQW-A nrPDB 52 4e-07 2ZBZ-A nrPDB 52 5e-07 4WPZ-A nrPDB 52 6e-07 5DQN-A nrPDB 52 7e-07 5IT1-A nrPDB 51 9e-07 1ODO-A nrPDB 51 1e-06 3B98-A nrPDB 51 1e-06 5Y1I-A nrPDB 51 2e-06 2RFC-A nrPDB 51 2e-06 5LIE-A nrPDB 50 2e-06 3R9C-A nrPDB 50 2e-06 1CPT-A nrPDB 50 2e-06 5XW2-A nrPDB 50 3e-06 4Z5Q-A nrPDB 50 3e-06 4YZR-A nrPDB 49 4e-06 3IVY-A nrPDB 49 4e-06 3NC3-A nrPDB 49 4e-06 2WM5-A nrPDB 49 5e-06 1F4U-A nrPDB 49 7e-06 5HIW-A nrPDB 47 1e-05 6CVC-A nrPDB 47 1e-05 2X9P-A nrPDB 47 2e-05 5H1Z-A nrPDB 47 2e-05 5DE9-A nrPDB 47 2e-05 2RCM-A nrPDB 46 5e-05 2WIY-A nrPDB 45 7e-05 6HQD-A nrPDB 45 8e-05 6G71-A nrPDB 45 9e-05 3WEC-A nrPDB 45 9e-05 3A1L-A nrPDB 45 9e-05 2FR7-A nrPDB 44 1e-04 5Z9I-A nrPDB 44 2e-04 4DO1-A nrPDB 43 3e-04 6M7L-A nrPDB 43 3e-04 2IJ7-A nrPDB 43 4e-04 1LG9-A nrPDB 43 4e-04 6GII-A nrPDB 42 4e-04 1EHE-A nrPDB 42 5e-04 5EX6-C nrPDB 42 6e-04 6GMF-A nrPDB 42 6e-04 1UED-A nrPDB 42 7e-04 4XE3-A nrPDB 42 7e-04 2IAG-A nrPDB 41 0.001 3DBM-A nrPDB 41 0.001 2QBO-A nrPDB 40 0.002 5L1U-A nrPDB 40 0.002 4C9K-A nrPDB 40 0.003 5OMS-A nrPDB 40 0.003 6FSH-A nrPDB 40 0.003 2NZA-A nrPDB 39 0.007 3OO3-A nrPDB 39 0.008 6G5O-A nrPDB 37 0.024 2UUQ-A nrPDB 37 0.028 3J8B-C nrPDB 35 0.081 4TX3-A nrPDB 35 0.085 5A5T-C nrPDB 35 0.094 6BLD-A nrPDB 34 0.13 5EX8-A nrPDB 33 0.21 6ERI-Az nrPDB 30 2.1 5MLC-9 nrPDB 30 2.8 1IS1-A nrPDB 28 6.7 2MAH-A nrPDB 28 7.6 3IEI-A nrPDB 28 8.8 >5VEU-A nrPDB Length = 480 Score = 976 bits (2523), Expect = 0.0, Method: Compositional matrix adjust. Identities = 474/476 (99%), Positives = 475/476 (99%) Query: 22 LYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPV 81 + LYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPV Sbjct: 1 MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPV 60 Query: 82 LAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGK 141 LAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGK Sbjct: 61 LAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGK 120 Query: 142 LKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQD 201 LKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQD Sbjct: 121 LKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQD 180 Query: 202 PFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRL 261 PFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRL Sbjct: 181 PFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRL 240 Query: 262 NDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL 321 NDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL Sbjct: 241 NDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL 300 Query: 322 ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDV 381 ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDV Sbjct: 301 ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDV 360 Query: 382 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNC 441 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNC Sbjct: 361 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNC 420 Query: 442 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDG 497 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDG Sbjct: 421 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDG 476 >6DA2-A nrPDB Length = 487 Score = 853 bits (2203), Expect = 0.0, Method: Compositional matrix adjust. Identities = 404/482 (83%), Positives = 442/482 (91%), Gaps = 1/482 (0%) Query: 21 LLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLP 80 + YLYGT +HGLFK+LGIPGPTPLP LGN+LSY +G FD EC+KKYGK+WG Y+GQ P Sbjct: 1 MAYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQP 60 Query: 81 VLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSG 140 VLAITDPD+I+TVLVKECYSVFTNRR GPVGFMKSAIS+AEDEEWKR+RSLLSPTFTSG Sbjct: 61 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 120 Query: 141 KLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200 KLKEM PIIAQYGDVLVRNLRREAE GKPVTLKD+FGAYSMDVIT TSFGVNIDSLNNPQ Sbjct: 121 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ 180 Query: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSR 260 DPFVE+TKK L+F FLDP FLSI +FPFL P+ E LN+ +FP++ NFL KSV RMK+SR Sbjct: 181 DPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESR 240 Query: 261 LNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYE 320 L D QKHR+DFLQLMIDSQNSKETESHKALSDLEL AQSIIFIFAGYETTSSVLSF +YE Sbjct: 241 LEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYE 300 Query: 321 LATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKD 380 LATHPDVQQKLQ+EIDAVLPNKAPPTYD V+QMEYLDMVVNETLRLFP+A+RLER CKKD Sbjct: 301 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKD 360 Query: 381 VEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK-KDSIDPYIYTPFGTGPR 439 VEING+FIPKG +V+IP+YALH DPKYWTEPE+F PERFSKK KD+IDPYIYTPFG+GPR Sbjct: 361 VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 420 Query: 440 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTL 499 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL GLLQPEKP+VLKV+SRDGT+ Sbjct: 421 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTV 480 Query: 500 SG 501 SG Sbjct: 481 SG 482 >6C94-A nrPDB Length = 497 Score = 160 bits (406), Expect = 9e-40, Method: Compositional matrix adjust. Identities = 123/461 (26%), Positives = 213/461 (46%), Gaps = 41/461 (8%) Query: 38 IPGPTPLPLLGNVLSYRQG-------LWKFDTECYKKYGKMW-GTYEGQLPVLAITDPDV 89 PGP L G+ L ++ W T+ + +W G + G L I +PD Sbjct: 24 FPGPPTHWLFGHALEIQKTGSLDKVVTW---TQQFPYAHPLWVGQFIG---FLNIYEPDY 77 Query: 90 IRTVLVK------ECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLK 143 + V + + Y F + ++ + + + +W + R LL+P F LK Sbjct: 78 AKAVYSRGDPKAPDVYDFF--------LQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLK 129 Query: 144 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF 203 I A +++ ++A +GK + G ++D + +FG LN+ + Sbjct: 130 PYVAIFADSTRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSY 189 Query: 204 VESTKKF--LKFGFLDPLFLSIILFPFLTP----VFEALNVSLFPKDTINFLSKSVNRMK 257 + + L +D +LTP A + D + K+ + + Sbjct: 190 YVAVSELTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAALQDE 249 Query: 258 KSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFT 317 K R + + LDFL +++D + ES LSD +L A+ F+F G++TT+S +S+ Sbjct: 250 KEREKIQNRRHLDFLDILLDVRG----ESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWF 305 Query: 318 LYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTC 377 LY +A +P+ QQ+ ++E+ +L ++ ++ + +M YL M + E RL+P ++ R Sbjct: 306 LYCMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQL 365 Query: 378 KKDVE-INGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDS-IDPYIYTPFG 435 K V ++G +P GS++ + YALH + W +PE F P RFS + S PY + PF Sbjct: 366 SKPVSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFS 425 Query: 436 TGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 476 GPRNCIG +FA+ MK+ L F F ++P+KL Sbjct: 426 AGPRNCIGQQFAMNEMKVVTALCLLRFEFS-VDPLRLPIKL 465 >4R20-A nrPDB Length = 486 Score = 147 bits (372), Expect = 9e-36, Method: Compositional matrix adjust. Identities = 130/454 (28%), Positives = 210/454 (46%), Gaps = 57/454 (12%) Query: 62 TECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSA---I 118 T+ +YG ++G Y G L +++ ++R VL++ F R + + I Sbjct: 46 TQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGRE-FAGRPKMVTTDLLTQGGKDI 104 Query: 119 SLAE-DEEWKRIRSLLSPTFT-----SGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTL 172 + A+ WK R L+ +FT S KL+ I+ + D L L +A +G+ L Sbjct: 105 AFADYSPLWKNHRRLVHSSFTLFGEGSNKLQT---IVQEAADSLCEEL--QACRGQSSDL 159 Query: 173 KDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKF-------LKFGFLDPLFLSIIL 225 + M +T + S P DP +++ ++ + G L +F + + Sbjct: 160 SVVL----MRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWLRI 215 Query: 226 FPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKE-- 283 FP + L + +D L K + KKS + + LD L+I Q Sbjct: 216 FP--NKDLKRLKECVSIRD--QLLYKKLLEHKKSLTPGEPRDLLD--ALLIGQQRGSGGA 269 Query: 284 ---TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLP 340 TE H ++ E AG ETTS+ L +T+ L HP +Q+++Q E+D + Sbjct: 270 DDITEDHVLMTAAEAFG-------AGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVG 322 Query: 341 NKAPPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTY 399 PP + LD V+ E +R+ PV+ I + +D + G +PKG+ V++ + Sbjct: 323 VDRPPCLSDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMW 382 Query: 400 ALHHDPKYWTEPEEFRPERF---SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALI 456 A+HHDPK+W +PE+F PERF S KK + ++ PFG GPR C+G A + + L + Sbjct: 383 AIHHDPKHWDQPEQFNPERFLEPSGKKKTQSSFL--PFGAGPRVCVGESLARIELFLFVS 440 Query: 457 RVLQNFSFKPCKETQIPLKLDTQG----LLQPEK 486 R LQ FSF E +P D QG +LQPE+ Sbjct: 441 RPLQRFSFSCPSEASLP---DLQGRFGVVLQPER 471 >3K9V-A nrPDB Length = 482 Score = 138 bits (348), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 127/476 (26%), Positives = 219/476 (46%), Gaps = 43/476 (9%) Query: 38 IPGPTPLPLLGNVLS--YRQGLWK-FDT--ECYKKYGKMWGTYEGQLPVLAITDPDVIRT 92 +PGPT PLLG++L ++ GL K DT E +KKYG+++ G + + P ++ Sbjct: 26 LPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEA 85 Query: 93 VLVKECYSVFTNRRSLGPVGFMKS------AISLAEDEEWKRIRSLLSPTFTSGKLKEMF 146 + E S R + P + + + E +EW+R+RS K E+ Sbjct: 86 LYRTE--SAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLM--KPVEIM 141 Query: 147 PIIAQYGDVLVRNLRREAE----KGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDP 202 + + +VL L R E +G+ L +S + I + L Sbjct: 142 KLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQK---- 197 Query: 203 FVESTKKFLKFGFLDPLFLSIILFPFLTPV--FEALNVSLFPKDTINF--LSKSVNRMKK 258 E+ ++ L F +S +TPV + LN ++ T+ + + KSV Sbjct: 198 --ETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCID 255 Query: 259 SRLND-KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFT 317 +RL Q+ DFL + + + E + A+++L+LAA ETT++ L + Sbjct: 256 NRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAA---------VETTANSLMWI 306 Query: 318 LYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTC 377 LY L+ +P Q++L +E+ +VLP+ P + + M YL + E++RL P RT Sbjct: 307 LYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTL 366 Query: 378 KKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTG 437 K + +PKG+++ + T L + + +FRPER+ +K+ I+P+ + PFG G Sbjct: 367 DKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIG 426 Query: 438 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQP--EKPIVLK 491 R CIG R A + + LAL ++Q + P+++ G+L P E PI + Sbjct: 427 KRMCIGRRLAELQLHLALCWIIQKYDIVATDNE--PVEMLHLGILVPSRELPIAFR 480 >4KPA-A nrPDB Length = 494 Score = 138 bits (347), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 119/388 (30%), Positives = 186/388 (47%), Gaps = 24/388 (6%) Query: 119 SLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGA 178 S ++ WK+ ++L P+F+ +K ++ LV+ R + + + + Sbjct: 113 SWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWER-LNADEHIEVPEDMTR 171 Query: 179 YSMDVITGTSFGVNIDSLNNPQ-DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALN 237 ++D I F +S Q PF+ S + L D + P ++ N Sbjct: 172 LTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRAL-----DEAMNKLQRANPDDPAYDE-N 225 Query: 238 VSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAA 297 F +D I ++ V+++ R ++ D L M+ N K+ E+ + L D + Sbjct: 226 KRQFQED-IKVMNDLVDKIIADRKASGEQSD-DLLTHML---NGKDPETGEPLDDENIRY 280 Query: 298 QSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLD 357 Q I F+ AG+ETTS +LSF LY L +P V QK +E VL + P+Y V Q++Y+ Sbjct: 281 QIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPV-PSYKQVKQLKYVG 339 Query: 358 MVVNETLRLFPVAIRLERTCKKDVEINGVF-IPKGS--MVVIPTYALHHDPKYWTEP-EE 413 MV+NE LRL+P A K+D + G + + KG MV+IP LH D W + EE Sbjct: 340 MVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQ--LHRDKTIWGDDVEE 397 Query: 414 FRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 473 FRPERF + +I + + PFG G R CIG +FAL L L +L++F F+ T Sbjct: 398 FRPERF-ENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFE--DHTNYE 454 Query: 474 LKLDTQGLLQPEKPIVLKVDSRDGTLSG 501 L + L+PE V+K S+ L G Sbjct: 455 LDIKETLTLKPEG-FVVKAKSKKIPLGG 481 >3MDV-A nrPDB Length = 456 Score = 137 bits (345), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 110/439 (25%), Positives = 206/439 (46%), Gaps = 27/439 (6%) Query: 66 KKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNR-RSL----GPVGFMKSAISL 120 KKYG + + +T P+ ++ L+ Y+ + R+L G F + +S Sbjct: 21 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSE 80 Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 180 E W + R ++ F+ L + + + LV L +A+ PV+++D+ + Sbjct: 81 CNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTA 140 Query: 181 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL 240 MD++ +FG+ L Q P ++ K L+ G L FL + L Sbjct: 141 MDILAKAAFGMETSMLLGAQKPLSQAVKLMLE-GITAS---RNTLAKFLPGKRKQLREV- 195 Query: 241 FPKDTINFLSKSVNR----MKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELA 296 +++I FL + V R ++ L ++ D L ++ ++ A D L Sbjct: 196 --RESIRFL-RQVGRDWVQRRREALKRGEEVPADILTQILKAEEG-------AQDDEGLL 245 Query: 297 AQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYL 356 + F AG+ET+++ L+FT+ EL+ P++ +LQ E+D V+ +K ++ + +++YL Sbjct: 246 DNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYL 305 Query: 357 DMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRP 416 V+ E+LRL+P A R +++ I+GV +P + ++ TY + Y+ +P F P Sbjct: 306 SQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNP 365 Query: 417 ERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 476 +RF + Y PF G R+CIG +FA M +K+ + ++LQ F+ + L+ Sbjct: 366 DRFGPGAPK-PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQ- 423 Query: 477 DTQGLLQPEKPIVLKVDSR 495 Q L+P P++ + R Sbjct: 424 -EQATLKPLDPVLCTLRPR 441 >4H1N-A nrPDB Length = 479 Score = 135 bits (340), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 117/454 (25%), Positives = 190/454 (41%), Gaps = 56/454 (12%) Query: 39 PGPTPLPLLGNVLSY-RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97 PGP+PLP+LGN+L R+GL + +KYG ++ Y G PV+ + D IR LV + Sbjct: 13 PGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAIREALVDQ 72 Query: 98 CYSVFTNRRSLGPVG--FMKSAISLAEDEEWKRIRSLLSPT---FTSGKLKEMFPIIAQY 152 F+ R + V F + A E W+ +R T F GK + + I + Sbjct: 73 A-EAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGMGK-RSVEERIQEE 130 Query: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212 LV LR+ KG + +F + + ++I FG + Sbjct: 131 ARCLVEELRKS--KGALLDNTLLFHSITSNIICSIVFGK--------------------R 168 Query: 213 FGFLDPLFLSII-------------------LFPFLTPVFEALNVSLFP--KDTINFLSK 251 F + DP+FL ++ LF F + ++ ++ F+ + Sbjct: 169 FDYKDPVFLRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQ 228 Query: 252 SVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTS 311 SV +K R + DF+ + + +++ L + AG ETTS Sbjct: 229 SV---EKHRATLDPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTS 285 Query: 312 SVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP-VA 370 + L + + +P V +++QKEI+ V+ + PP D +M Y D V++E RL + Sbjct: 286 TTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIP 345 Query: 371 IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY- 429 + T KD + G IPK + V + HDP+Y+ P F P F ++ Sbjct: 346 FGVPHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNE 405 Query: 430 IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 + PF G R C+G A + L +LQNFS Sbjct: 406 GFMPFSLGKRICLGEGIARTELFLFFTTILQNFS 439 >5YLW-A nrPDB Length = 495 Score = 132 bits (333), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 115/485 (23%), Positives = 216/485 (44%), Gaps = 52/485 (10%) Query: 9 VETWLLLAVSLVLLYLYGTRTHGLFKRLGI--PGPTPLPLLGNVLSYRQGLWKFDTECYK 66 ++++ LLA L ++ T T F+R PGP P P++GN+L + + K Sbjct: 1 MDSFPLLAA---LFFIAATITFLSFRRRRNLPPGPFPYPIVGNMLQLGANPHQVFAKLSK 57 Query: 67 KYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPV----------GFMKS 116 +YG + + G L + ++ P++ + +L + VF+ R V GF+ Sbjct: 58 RYGPLMSIHLGSLYTVIVSSPEMAKEILHRHG-QVFSGRTIAQAVHACDHDKISMGFLPV 116 Query: 117 AISLAEDEEWKRIRSLLSPT-FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDI 175 A EW+ +R + F++ ++ + Q L+ ++++ ++ G+ V +++ Sbjct: 117 A------SEWRDMRKICKEQMFSNQSMEASQGLRRQKLQQLLDHVQKCSDSGRAVDIREA 170 Query: 176 FGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSII-------LFPF 228 ++++++ T F + +K ++F + +I+ FP Sbjct: 171 AFITTLNLMSATLFSSQATEFD---------SKATMEFKEIIEGVATIVGVPNFADYFPI 221 Query: 229 LTPVFEALNVS-----LFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKE 283 L P F+ V F K R++ R N + DFL++++D + E Sbjct: 222 LRP-FDPQGVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANE 280 Query: 284 TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKA 343 + L + G +T ++ + + + EL +PD +L+ E+ +V ++ Sbjct: 281 FK----LKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEK 336 Query: 344 PPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALH 402 A+ ++ YL V+ E +R+ P + L R + D E+NG IPKG+ ++I YA+ Sbjct: 337 IVDESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIG 396 Query: 403 HDPKYWTEPEEFRPERFSKKKDSI--DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQ 460 DP WT+PE F PERF K Y PFG+G R C GM A + +A ++ Sbjct: 397 RDPSIWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVH 456 Query: 461 NFSFK 465 NF +K Sbjct: 457 NFDWK 461 >5W0C-A nrPDB Length = 477 Score = 124 bits (311), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 132/458 (28%), Positives = 202/458 (44%), Gaps = 37/458 (8%) Query: 39 PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97 PGPTPLP++GN+L + + K T K YG ++ Y G P++ + + ++ L+ + Sbjct: 14 PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALI-D 72 Query: 98 CYSVFTNRR--SLGPVGFMKSAISLAEDEEWKRIR--SLLS-PTFTSGKLKEMFPIIAQY 152 F+ R L I + ++WK IR SL++ F GK + + + + Sbjct: 73 LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 131 Query: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212 LV LR+ K P I G +VI F D + +E + +K Sbjct: 132 ARCLVEELRKT--KASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIK 189 Query: 213 FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHR---- 268 L ++ I +P+ + FP T N L K+V MK L ++H+ Sbjct: 190 I--LSSPWIQIC--NNFSPI-----IDYFP-GTHNKLLKNVAFMKSYILEKVKEHQESMD 239 Query: 269 LDFLQLMIDSQNSK-ETESHKALSDL---ELAAQSIIFIFAGYETTSSVLSFTLYELATH 324 ++ Q ID K E E H S+ L ++ AG ETTS+ L + L L H Sbjct: 240 MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKH 299 Query: 325 PDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR---LFPVAIRLERTCKKDV 381 P+V K+Q+EI+ V+ P M Y D VV+E R L P ++ TC D+ Sbjct: 300 PEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC--DI 357 Query: 382 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFGTGPRN 440 + IPKG+ ++I ++ HD K + PE F P F + + Y PF G R Sbjct: 358 KFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRI 417 Query: 441 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT 478 C+G A M + L L +LQNF+ K + P LDT Sbjct: 418 CVGEALAGMELFLFLTSILQNFNLKSLVD---PKNLDT 452 >1N6B-A nrPDB Length = 473 Score = 119 bits (297), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 122/459 (26%), Positives = 199/459 (43%), Gaps = 32/459 (6%) Query: 39 PGPTPLPLLGNVLSY-----RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTV 93 PGPTP P++GN+L + L KF +ECY G ++ Y G P + + + ++ Sbjct: 13 PGPTPFPIIGNILQIDAKDISKSLTKF-SECY---GPVFTVYLGMKPTVVLHGYEAVKEA 68 Query: 94 LVKECYSVFTNRRSLGPVGFMKSAISLA--EDEEWKRIR--SLLS-PTFTSGKLKEMFPI 148 LV + F R S+ + + + +A + WK +R SL++ F GK + + Sbjct: 69 LV-DLGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGK-RSIEDR 126 Query: 149 IAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTK 208 I + LV LR+ P I G +VI F D + +ES Sbjct: 127 IQEEARCLVEELRKT--NASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLMESLH 184 Query: 209 KFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPK-DTI-NFLSKSVNRMKKSRLNDKQK 266 + ++ P FP L F ++ +L D I NF+ + V +K + + Sbjct: 185 ENVEL-LGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVNNPR 243 Query: 267 HRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPD 326 +D + ++ +N+ E L L +A + AG ETTS+ L ++L L HP+ Sbjct: 244 DFIDCFLIKMEQENNLEF----TLESLVIAVSDLFG--AGTETTSTTLRYSLLLLLKHPE 297 Query: 327 VQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEING 385 V ++Q+EI+ V+ P +M Y D V++E R + L +DV Sbjct: 298 VAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRN 357 Query: 386 VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFGTGPRNCIGM 444 FIPKG+ ++ ++ HD K + P+ F P F + + Y PF G R C+G Sbjct: 358 YFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGE 417 Query: 445 RFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQ 483 A M + L L +LQNF + E P LD ++ Sbjct: 418 GLARMELFLFLTSILQNFKLQSLVE---PKDLDITAVVN 453 >3DL9-A nrPDB Length = 479 Score = 117 bits (292), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 113/448 (25%), Positives = 199/448 (44%), Gaps = 39/448 (8%) Query: 68 YGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMK-----SAISLAE 122 YG+++ G + + + DV++ LV + +F +R L P+ FMK ++ Sbjct: 47 YGEIFSLDLGGISTVVLNGYDVVKECLVHQS-EIFADRPCL-PL-FMKMTKMGGLLNSRY 103 Query: 123 DEEWKRIRSLLSPTFTS-GKLKEMFP--IIAQ---YGDVLVRNLRREAEKGKPVTLKDIF 176 W R L +F G ++ F I+ + + D + E KG+P K + Sbjct: 104 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAI------ETYKGRPFDFKQLI 157 Query: 177 GAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEAL 236 ++ FG + +E + ++ +FL FP++ + Sbjct: 158 TNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFL-YNAFPWIGILPFGK 216 Query: 237 NVSLFPKDTI--NFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLE 294 + LF + +FLS+ + +K+ +N K + F+ +D + + + S Sbjct: 217 HQQLFRNAAVVYDFLSRLI---EKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKEN 273 Query: 295 LAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQME 354 L I AG ETT++VL + + +A +P++Q ++QKEID ++ P++D +M Sbjct: 274 LIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMP 333 Query: 355 YLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413 Y + V++E LR + + + +D + G IPKG+ V+ Y++H D KYW +PE Sbjct: 334 YTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEV 393 Query: 414 FRPERF------SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPC 467 F PERF KK+++ PF G R+C+G A M M L +LQ F Sbjct: 394 FHPERFLDSSGYFAKKEAL-----VPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP 448 Query: 468 KETQIPLKLDTQGLLQPEKPIVLKVDSR 495 E LK LQP+ P ++ + R Sbjct: 449 HELVPDLKPRLGMTLQPQ-PYLICAERR 475 >4GQS-A nrPDB Length = 477 Score = 116 bits (291), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 123/450 (27%), Positives = 193/450 (42%), Gaps = 44/450 (9%) Query: 39 PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97 PGPTPLP++GN+L + + K T K YG ++ Y G ++ + +V++ L+ + Sbjct: 14 PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALI-D 72 Query: 98 CYSVFTNRRS--LGPVGFMKSAISLAEDEEWKRIR--SLLS-PTFTSGKLKEMFPIIAQY 152 F+ R L I + + WK IR SL++ F GK + + + + Sbjct: 73 LGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 131 Query: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212 LV LR+ K P I G +VI F Q F ++FL Sbjct: 132 ARCLVEELRKT--KASPCDPTFILGCAPCNVICSIIF----------QKRFDYKDQQFL- 178 Query: 213 FGFLDPLFLSIILFPFLTPVFEALN-----VSLFPKDTINFLSKSVNRMKKSRLNDKQKH 267 ++ L +I + TP + N + FP T N L K++ M+ L ++H Sbjct: 179 -NLMEKLNENIRIVS--TPWIQICNNFPTIIDYFP-GTHNKLLKNLAFMESDILEKVKEH 234 Query: 268 R--------LDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLY 319 + DF+ + ++ + L + + AG ETTS+ L + L Sbjct: 235 QESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALL 294 Query: 320 ELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR---LFPVAIRLERT 376 L HP+V K+Q+EI+ V+ P M Y D VV+E R L P ++ T Sbjct: 295 LLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVT 354 Query: 377 CKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFG 435 C DV+ IPKG+ ++ ++ HD K + PE F P F + + Y PF Sbjct: 355 C--DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFS 412 Query: 436 TGPRNCIGMRFALMNMKLALIRVLQNFSFK 465 G R C+G A M + L L +LQNF+ K Sbjct: 413 AGKRICVGEGLARMELFLFLTFILQNFNLK 442 >5E58-A nrPDB Length = 493 Score = 115 bits (289), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 109/433 (25%), Positives = 183/433 (42%), Gaps = 45/433 (10%) Query: 54 RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGF 113 R G +KYG ++ + G PV+ + + IR LV + F+ R G + Sbjct: 48 RGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQA-EAFSGR---GTIAV 103 Query: 114 MKSAIS-----LAEDEEWKRIRSLLSPT---FTSGKLKEMFPIIAQYGDVLVRNLRREAE 165 +K I + E WK +R T F GK + + I + LV L++ Sbjct: 104 IKPVIGDYGMIFSNGERWKVLRRFSLATMRDFGMGK-RSVEDRIQEEAQCLVEELQKS-- 160 Query: 166 KGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIIL 225 +G P+ +F + ++I FG D + ++FL+ LD + + L Sbjct: 161 QGAPLDPTFLFQCITANIICSIVFGERYDYKD----------RQFLRL--LDLFYRTFSL 208 Query: 226 FP-FLTPVFEALN--VSLFP----------KDTINFLSKSVNRMKKSRLNDKQKHRLDFL 272 F + VFE + + FP ++ ++++ +SV +K R + DF+ Sbjct: 209 MSSFSSQVFELFSGFMKYFPGAHRQITRNLQEILDYVGQSV---EKHRATLDPSNPRDFI 265 Query: 273 QLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQ 332 + +++ H L + FAG ETTS+ L + + +P V +K+Q Sbjct: 266 DTYLLRMEKEKSNQHTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQ 325 Query: 333 KEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKG 391 KEID V+ + PT + +M Y D V++E R +A I KD G +PK Sbjct: 326 KEIDQVIGSHRLPTLEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKN 385 Query: 392 SMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI-DPYIYTPFGTGPRNCIGMRFALMN 450 + V + HDP+Y+ +P F P+ F ++ + PF G R C+G A Sbjct: 386 TEVYPILSSALHDPQYFEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNE 445 Query: 451 MKLALIRVLQNFS 463 + L +LQNFS Sbjct: 446 LFLFFTTILQNFS 458 >3QZ1-A nrPDB Length = 496 Score = 115 bits (288), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 99/351 (28%), Positives = 156/351 (44%), Gaps = 25/351 (7%) Query: 126 WKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVIT 185 WK + L G M P + Q +R +A G PVT++ F + +I Sbjct: 117 WKAHKKLTRSALLLGTRSSMEPWVDQLTQEFCERMRVQA--GAPVTIQKEFSLLTCSIIC 174 Query: 186 GTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDT 245 +FG D+L + V+ K + L + L F P L ++ +D Sbjct: 175 YLTFGNKEDTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRFFPNPGLWRLKQAIENRD- 233 Query: 246 INFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKET-----ESHKALSDLELAAQSI 300 + + K + R K+S + + + D++ + Q +E E H +S ++L Sbjct: 234 -HMVEKQLRRHKESMVAGQWRDMTDYMLQGVGRQRVEEGPGQLLEGHVHMSVVDL----- 287 Query: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP---TYDAVVQMEYLD 357 G ETT+S LS+ + L HP++Q++LQ+E+D L A TY ++ L+ Sbjct: 288 --FIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELGPGASCSRVTYKDRARLPLLN 345 Query: 358 MVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTY-ALHHDPKYWTEPEEFR 415 + E LRL PV + L + I G IP+G MVVIP H D W +P EFR Sbjct: 346 ATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEG-MVVIPNLQGAHLDETVWEQPHEFR 404 Query: 416 PERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466 P+RF + +P FG G R C+G A + + + L R+LQ F+ P Sbjct: 405 PDRFLEP--GANPSALA-FGCGARVCLGESLARLELFVVLARLLQAFTLLP 452 >2PG7-A nrPDB Length = 476 Score = 115 bits (288), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 115/469 (24%), Positives = 203/469 (43%), Gaps = 61/469 (13%) Query: 39 PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97 PGPTPLP +GN L + ++ + ++YG ++ + G V+ + D +R LV + Sbjct: 13 PGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQ 72 Query: 98 CYSVFTNRRSLGPVG--FMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDV 155 F+ R F + + E K++R F+ L++ + + G Sbjct: 73 AEE-FSGRGEQATFDWVFKGYGVVFSNGERAKQLRR-----FSIATLRDF--GVGKRG-- 122 Query: 156 LVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDS---LNNPQDPFVESTKKFLK 212 + ++ EA + +D + GT G NID L+ + S + Sbjct: 123 IEERIQEEA-------------GFLIDALRGTG-GANIDPTFFLSRTVSNVISSIVFGDR 168 Query: 213 FGFLDPLFLSII-----LFPF-------LTPVFEALNVSL-FPKDTI--------NFLSK 251 F + D FLS++ +F F L +F ++ L P+ +F++K Sbjct: 169 FDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAK 228 Query: 252 SVNRMKKSRLNDKQKHRLD-FLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETT 310 V +++ + + +D FL M + + + TE + L ++ G ET Sbjct: 229 KVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLK----NLVMTTLQLFVGGTETV 284 Query: 311 SSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA 370 S+ L + L HP+V+ K+ +EID V+ P ++ +M Y++ V++E R V Sbjct: 285 STTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVI 344 Query: 371 -IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY 429 + L R KKD + F+PKG+ V ++ DP +++ P++F P+ F +K Sbjct: 345 PMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKS 404 Query: 430 -IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLD 477 + PF G RNC G A M + L V+QNF K +Q P +D Sbjct: 405 DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFR---LKSSQSPKDID 450 >2NNH-A nrPDB Length = 476 Score = 114 bits (285), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 123/450 (27%), Positives = 195/450 (43%), Gaps = 44/450 (9%) Query: 39 PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVK- 96 PGPTPLP++GN+L + + K T K YG ++ Y G P++ + ++ L+ Sbjct: 13 PGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDN 72 Query: 97 -ECYSVFTN----RRSLGPVGFMKSAISLAEDEEWKRIRSLLSPT---FTSGKLKEMFPI 148 E +S N +R +G + S + WK IR T F GK + + Sbjct: 73 GEEFSGRGNSPISQRITKGLGIISS-----NGKRWKEIRRFSLTTLRNFGMGK-RSIEDR 126 Query: 149 IAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTK 208 + + LV LR+ K P I G +VI F D + F+ K Sbjct: 127 VQEEAHCLVEELRKT--KASPCDPTFILGCAPCNVICSVVFQKRFDYKD---QNFLTLMK 181 Query: 209 KFLK-FGFLDPLFLSIIL-FPFLTPVFEAL------NVSLFPKDTINFLSKSVNRMKKSR 260 +F + F L+ ++ + FP L F NV+L T +++ + V + S Sbjct: 182 RFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVAL----TRSYIREKVKEHQASL 237 Query: 261 LNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF-AGYETTSSVLSFTLY 319 + + +D + ++ +E ++ K+ ++E ++ +F AG ETTS+ L + L Sbjct: 238 DVNNPRDFIDCFLIKME----QEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLL 293 Query: 320 ELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR---LFPVAIRLERT 376 L HP+V K+Q+EID V+ P M Y D VV+E R L P + T Sbjct: 294 LLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVT 353 Query: 377 CKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFG 435 D + IPKG+ ++ ++ HD K + P F P F K + Y PF Sbjct: 354 --TDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFS 411 Query: 436 TGPRNCIGMRFALMNMKLALIRVLQNFSFK 465 G R C G A M + L L +LQNF+ K Sbjct: 412 AGKRICAGEGLARMELFLFLTTILQNFNLK 441 >5UYS-A nrPDB Length = 494 Score = 114 bits (285), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 118/435 (27%), Positives = 195/435 (44%), Gaps = 45/435 (10%) Query: 66 KKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFM---KSAISLAE 122 KKYG ++ G + + + + VL+K+ F+ R + + + I+ A+ Sbjct: 40 KKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKD-FSGRPQMATLDIASNNRKGIAFAD 98 Query: 123 D-EEWKRIRSLLSPTFTSGKL--KEMFPIIAQYGDVLVRNLRREAEKGKPVTLK-DIFGA 178 W+ R L TF K +++ II Q L L G+ + + +F A Sbjct: 99 SGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDML--ATHNGQSIDISFPVFVA 156 Query: 179 YSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLS--IILFPFLTPVFEAL 236 + +VI+ F + + DP + + + + G +D L + L P+L Sbjct: 157 VT-NVISLICFNTSYKN----GDPELNVIQNYNE-GIIDNLSKDSLVDLVPWL------- 203 Query: 237 NVSLFPKDTINFLSKSV----NRMKKSRLNDKQKHRLDFLQLMIDS----------QNSK 282 +FP T+ L V + + K N K+K R D + M+D+ N+ Sbjct: 204 --KIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAG 261 Query: 283 ETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNK 342 + + LSD + AG ETT+SV+ +TL L +P V++KL +EID + Sbjct: 262 PDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFS 321 Query: 343 APPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYAL 401 PT ++ L+ + E LRL PVA + + D I + KG+ V+I +AL Sbjct: 322 RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWAL 381 Query: 402 HHDPKYWTEPEEFRPERFSKKKDS--IDPYI-YTPFGTGPRNCIGMRFALMNMKLALIRV 458 HH+ K W +P++F PERF + I P + Y PFG GPR+CIG A + L + + Sbjct: 382 HHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWL 441 Query: 459 LQNFSFKPCKETQIP 473 LQ F + + Q+P Sbjct: 442 LQRFDLEVPDDGQLP 456 >5E0E-A nrPDB Length = 463 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 106/423 (25%), Positives = 181/423 (42%), Gaps = 49/423 (11%) Query: 66 KKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVG--FMKSAISLAED 123 +KYG ++ + G PV+ + + IR LV + F+ R ++ V F + A Sbjct: 32 EKYGDVFTVHLGPRPVVMLYGTEAIREALVDQA-EAFSGRGTIAVVEPIFRGYGVVFANG 90 Query: 124 EEWKRIRSLLSPT---FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 180 E WK +R T F GK + + I + LV R+ +G P+ +F + Sbjct: 91 ERWKALRRFSLVTMRDFGMGK-RSVEERIQEEARCLVEEFRKS--QGAPLDPTFLFQCIT 147 Query: 181 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL----SIILFPFLTPVFEAL 236 ++I FG D ++ FL L+L ++ F + VFE Sbjct: 148 ANIICSIVFGERFDYKDHQ---------------FLRLLYLFYQSFSLISSFSSQVFELF 192 Query: 237 N--VSLFP----------KDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKET 284 + + FP ++ ++++ +SV +K R H DF+ + +++ Sbjct: 193 SGFLKYFPGTHRQISRNLQEILDYIGQSV---EKHRATLDPSHPRDFIDTYLLRMEKEKS 249 Query: 285 ESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAP 344 H L + FAG ET+S+ L + + +P V +K+QKEID V+ + Sbjct: 250 NQHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRL 309 Query: 345 PTYDAVVQMEYLDMVVNETLR---LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYAL 401 PT + +M Y + V+ E R L P+ + + T KD G +PK + V + Sbjct: 310 PTLEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVT--KDTLFRGYLLPKNTEVYPILSSA 367 Query: 402 HHDPKYWTEPEEFRPERFSKKKDSI-DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQ 460 HDP+Y+ +P+ F P+ F ++ + PF G R C+G A + L +LQ Sbjct: 368 LHDPQYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQ 427 Query: 461 NFS 463 NFS Sbjct: 428 NFS 430 >2VE3-A nrPDB Length = 444 Score = 110 bits (276), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 61/182 (33%), Positives = 100/182 (54%), Gaps = 3/182 (1%) Query: 285 ESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAP 344 ++++ LS EL Q ++ +FAG+ET +S LS L H D+++++++E + + ++ Sbjct: 234 DNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLSQEL 293 Query: 345 PTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHD 404 T + + +M YLD V+ E LRL P R +D + G PKG +V H D Sbjct: 294 -TAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHFPKGWLVSYQISQTHAD 352 Query: 405 PKYWTEPEEFRPERFSKKKDSID--PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 P + +PE+F PERF+ + P+ + PFG G R C+G FA + MKL R++Q F Sbjct: 353 PDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQF 412 Query: 463 SF 464 + Sbjct: 413 DW 414 >6DWN-A nrPDB Length = 491 Score = 108 bits (270), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 115/466 (24%), Positives = 205/466 (43%), Gaps = 66/466 (14%) Query: 39 PGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE- 97 PGP PL+G++L+ + + ++YG + G PV+ ++ D IR LV++ Sbjct: 14 PGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQG 73 Query: 98 ----------CYSVFTNRRSL------GPVGFMK--------SAISLAEDEEWKRIRSLL 133 +++ +N +S+ GPV + + S+A D Sbjct: 74 DDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASD---------- 123 Query: 134 SPTFTSGKLKEMFPIIAQYGDVLVRNLRR-EAEKGKPVTLKDIFGAYSMDVITGTSFGVN 192 + TS L+E +++ +VL+ L+ A G + + + + +VI FG Sbjct: 124 PASSTSCYLEEH---VSKEAEVLISTLQELMAGPGHFNPYRYVVVSVT-NVICAICFGRR 179 Query: 193 IDSLNNPQDPFVESTKKFLKF-GFLDPL-FLSIILF---PFLTPVFEALNVSLFPKDTIN 247 D + V F + G +P F+ I+ + P L F+ LN + + Sbjct: 180 YDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLN-AFKDLNEKFY-----S 233 Query: 248 FLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF--- 304 F+ K V K+ ++ H D +I+ K+ + + ++++L+ + II I Sbjct: 234 FMQKMVKEHYKTF---EKGHIRDITDSLIEHCQEKQLDEN---ANVQLSDEKIINIVLDL 287 Query: 305 --AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362 AG++T ++ +S++L L +P VQ+K+Q+E+D V+ P + Y++ + E Sbjct: 288 FGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILE 347 Query: 363 TLRLFP-VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421 T R V + + +D + G +IPKG V + + ++HD K W P EF PERF Sbjct: 348 TFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 407 Query: 422 KKDSIDPYIYTP---FGTGPRNCIGMRFALMNMKLALIRVLQNFSF 464 +ID + FG G R CIG A + L L +LQ F Sbjct: 408 PDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 453 >4R1Z-A nrPDB Length = 439 Score = 108 bits (269), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 84/290 (28%), Positives = 144/290 (49%), Gaps = 35/290 (12%) Query: 225 LFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRL--------DFLQLMI 276 +FP+L +FP + L + ++ K ++H++ D L ++ Sbjct: 150 IFPWL---------QIFPNKDLTILRQCISIRDKLLQKKYEEHKVTYSDNVQRDLLDALL 200 Query: 277 DSQNSKETESHKALSDLELAAQSIIF----IF-AGYETTSSVLSFTLYELATHPDVQQKL 331 ++ S E ++ + D+ L ++ IF AG ETT++VL +++ L +P VQ+K+ Sbjct: 201 RAKRSSEN-NNSSTRDVGLTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKI 259 Query: 332 QKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPK 390 Q+E+D+ + + P + YL+ + E LR+ PV+ + + +D + + K Sbjct: 260 QEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPVSPLLIPHVALQDSSVGEYTVQK 319 Query: 391 GSMVVIPTYALHHDPKYWTEPEEFRPERF-SKKKDSI--DPYIYTPFGTGPRNCIGMRFA 447 G+ VVI ++LHHD K W PE F P RF +++ D + Y PFG G R C+G A Sbjct: 320 GTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALA 379 Query: 448 LMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG----LLQPEK-PIVLKV 492 M + L L +LQ F+ + +P D QG +LQP+K +V KV Sbjct: 380 KMELFLFLAWILQRFTLEMPTGQPLP---DLQGKFGVVLQPKKFKVVAKV 426 >5VBU-A nrPDB Length = 476 Score = 107 bits (268), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 86/352 (24%), Positives = 157/352 (44%), Gaps = 17/352 (4%) Query: 126 WKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVIT 185 WK + L G M P++ Q +R A+ G PV +++ F + +I Sbjct: 98 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMR--AQPGTPVAIEEEFSLLTCSIIC 155 Query: 186 GTSFGVNIDSLNNPQDPFVESTKKFLK-FGFLDPLFLSIILFP--FLTPVFEALNVSLFP 242 +FG I +N + + ++ LK + + +I F F P L ++ Sbjct: 156 YLTFGDKIKD-DNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEK 214 Query: 243 KDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIF 302 +D I + + + K+S + + + +D++ + + +E + +AA + Sbjct: 215 RDHI--VEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAA--VDL 270 Query: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPT---YDAVVQMEYLDMV 359 + G ETT++ LS+ + L HP++QQ+LQ+E+D L A + Y ++ L+ Sbjct: 271 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNAT 330 Query: 360 VNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418 + E LRL PV + L + I+G IP+G++++ H D W P EF P+R Sbjct: 331 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 390 Query: 419 FSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 470 F + + FG G R C+G A + + + L R+LQ F+ P + Sbjct: 391 FLEPGKNSRALA---FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDA 439 >2HI4-A nrPDB Length = 495 Score = 107 bits (268), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 115/460 (25%), Positives = 198/460 (43%), Gaps = 55/460 (11%) Query: 39 PGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE- 97 P P PLLG+VL+ + + ++YG + G PVL ++ D IR LV++ Sbjct: 19 PEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQG 78 Query: 98 ----------CYSVFTNRRSL------GPVGFMK--------SAISLAEDEEWKRIRSLL 133 ++ T+ +SL GPV + + S+A D S Sbjct: 79 DDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPA-----SSS 133 Query: 134 SPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNI 193 S KE +I++ +++ + V++ ++ GA FG + Sbjct: 134 SCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGA--------MCFGQHF 185 Query: 194 DSLNNPQDPFVESTKKFLKFGFL-DPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKS 252 ++ V++T +F++ +PL IL P + F + + FL K+ Sbjct: 186 PESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA--FNQRFLWFLQKT 243 Query: 253 VNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF-AGYETTS 311 V + D K+ + + + + K + L E + IF AG++T + Sbjct: 244 V----QEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVT 299 Query: 312 SVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR---LFP 368 + +S++L L T P++Q+K+QKE+D V+ + P Q+ YL+ + ET R P Sbjct: 300 TAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLP 359 Query: 369 VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SKKKDSID 427 I + +D +NG +IPK V + + ++HDP+ W +P EFRPERF + +I+ Sbjct: 360 FTI--PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAIN 417 Query: 428 PYIYTP---FGTGPRNCIGMRFALMNMKLALIRVLQNFSF 464 + FG G R CIG A + L L +LQ F Sbjct: 418 KPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEF 457 >3IBD-A nrPDB Length = 476 Score = 105 bits (262), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 101/423 (23%), Positives = 177/423 (41%), Gaps = 25/423 (5%) Query: 54 RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVG- 112 R+GL K +KYG ++ + G PV+ + + IR LV + F+ R + V Sbjct: 29 RRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKA-EAFSGRGKIAMVDP 87 Query: 113 -FMKSAISLAEDEEWKRIRSLLSPT---FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGK 168 F + A WK +R T F GK + + I + L+ LR+ KG Sbjct: 88 FFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRKS--KGA 144 Query: 169 PVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK-FGFLDPLFLSII-LF 226 + +F + + ++I FG + F++ F + F + +F + LF Sbjct: 145 LMDPTFLFQSITANIICSIVFG---KRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELF 201 Query: 227 PFLTPVFEALNVSLFPK-DTIN-FLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKET 284 F + ++ IN ++ SV + +++ + +D L ++ + S Sbjct: 202 SGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSN-- 259 Query: 285 ESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAP 344 +H S L ++ FAG ETTS+ L + + +P V +++ +EI+ V+ P Sbjct: 260 -AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRP 318 Query: 345 PTYDAVVQMEYLDMVVNETLR---LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYAL 401 P +M Y + V+ E R L P+ + + G IPK + V + Sbjct: 319 PELHDRAKMPYTEAVIYEIQRFSDLLPMGV--PHIVTQHTSFRGYIIPKDTEVFLILSTA 376 Query: 402 HHDPKYWTEPEEFRPERFSKKKDSIDPY-IYTPFGTGPRNCIGMRFALMNMKLALIRVLQ 460 HDP Y+ +P+ F P+ F ++ + PF G R C+G A + L +LQ Sbjct: 377 LHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQ 436 Query: 461 NFS 463 NFS Sbjct: 437 NFS 439 >3E6I-A nrPDB Length = 476 Score = 105 bits (261), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 113/447 (25%), Positives = 195/447 (43%), Gaps = 37/447 (8%) Query: 39 PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97 PGP PLP++GN+ + + K T +++G ++ Y G ++ + ++ L+ + Sbjct: 13 PGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL-D 71 Query: 98 CYSVFTNRRSLGPVGFMKS-AISLAEDEEWKRIRSLLSPTFTSGKLKEMF--PIIAQYGD 154 F+ R L + I WK IR T + + + I + Sbjct: 72 YKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAH 131 Query: 155 VLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFG 214 L+ LR+ +G+P + G +VI F + D + +KFL+ Sbjct: 132 FLLEALRKT--QGQPFDPTFLIGCAPCNVIADILFRKHFDY----------NDEKFLRLM 179 Query: 215 FLDPLFLSIILFPFLT-----PVF------EALNVSLFPKDTINFLSKSVNRMKKSRLND 263 +L ++ P+L P F V + ++S+ V +S + Sbjct: 180 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 239 Query: 264 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSII-FIFAGYETTSSVLSFTLYELA 322 + D L + ++ KE S + L ++ ++ FAG ETTS+ L + L L Sbjct: 240 CPRDLTDCLLVEME----KEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILM 295 Query: 323 THPDVQQKLQKEIDAVL-PNKAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKD 380 +P++++KL +EID V+ P++ P D +M Y+D VV+E R V L +D Sbjct: 296 KYPEIEEKLHEEIDRVIGPSRIPAIKDR-QEMPYMDAVVHEIQRFITLVPSNLPHEATRD 354 Query: 381 VEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFGTGPR 439 G IPKG++VV ++ +D + + +PE+F+PE F + Y PF TG R Sbjct: 355 TIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKR 414 Query: 440 NCIGMRFALMNMKLALIRVLQNFSFKP 466 C G A M + L L +LQ+F+ KP Sbjct: 415 VCAGEGLARMELFLLLCAILQHFNLKP 441 >6B82-A nrPDB Length = 509 Score = 105 bits (261), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 82/290 (28%), Positives = 143/290 (49%), Gaps = 35/290 (12%) Query: 225 LFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRL--------DFLQLMI 276 +FP+L +FP + L + ++ K ++H++ D L ++ Sbjct: 214 IFPWL---------QIFPNKDLRILRQCISIRDKLLQKKYEEHKVTYSDNVQRDLLDALL 264 Query: 277 DSQNSKETESHKALSDLELAAQSIIF----IF-AGYETTSSVLSFTLYELATHPDVQQKL 331 ++ S E ++ + D+ L ++ IF AG ETT++ L +++ L +P VQ+K+ Sbjct: 265 RAKRSSEN-NNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQVQRKI 323 Query: 332 QKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPK 390 Q+E+D+ + + P + YL+ + E +R+ PV+ + + +D + + K Sbjct: 324 QEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVALQDSSVGEYTVQK 383 Query: 391 GSMVVIPTYALHHDPKYWTEPEEFRPERF-SKKKDSI--DPYIYTPFGTGPRNCIGMRFA 447 G+ VVI ++LHHD K W PE F P RF +++ D + Y PFG G R C+G A Sbjct: 384 GTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALA 443 Query: 448 LMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG----LLQPEK-PIVLKV 492 M + L L +LQ F+ + +P D QG +LQP+K +V KV Sbjct: 444 KMELFLFLAWILQRFTLEMPTGQPLP---DLQGKFGVVLQPKKFKVVAKV 490 >3N9Z-A nrPDB Length = 487 Score = 101 bits (252), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 106/455 (23%), Positives = 189/455 (41%), Gaps = 54/455 (11%) Query: 62 TECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE-------------CYSVFTNRRSL 108 + ++KYG ++ G + + + DP+ + + E Y + R Sbjct: 39 VQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQR--- 95 Query: 109 GPVGFMKSAISLAEDEEWKRIR-----SLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRRE 163 P+G + L + WK+ R +++P T L + + + VL R +++ Sbjct: 96 -PIGVL-----LKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKA 149 Query: 164 AEKGKPVTLKDIFGAYSMDVITGTSFGVN---IDSLNNPQ-DPFVESTKKFLKFGF---- 215 + D ++ + IT FG ++ + NP+ F+++ + Sbjct: 150 GSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLN 209 Query: 216 LDPLFLSIILFPFLTPVFEALNVSLFPKD--TINFLSKSVNRMKKSRLNDKQKHRLDFLQ 273 L P + A +V D T NF + R K S +D +R + Sbjct: 210 LPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWEL--RQKGSVHHD---YRGILYR 264 Query: 274 LMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQK 333 L+ DS+ S E ++ A + G +TTS L + LYE+A + VQ L+ Sbjct: 265 LLGDSKMSFE----------DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRA 314 Query: 334 EIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSM 393 E+ A + + L + ETLRL P+++ L+R D+ + IP ++ Sbjct: 315 EVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTL 374 Query: 394 VVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKL 453 V + YAL +P ++ +PE F P R+ K +I + FG G R C+G R A + M + Sbjct: 375 VQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTI 434 Query: 454 ALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPI 488 LI +L+NF + + + + +L PEKPI Sbjct: 435 FLINMLENFRVEIQHLSDVGTTFNL--ILMPEKPI 467 >2W0A-A nrPDB Length = 455 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 105/207 (50%), Gaps = 2/207 (0%) Query: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353 E+ I +FAG+ T+S S+TL EL H D + E+D + + ++ A+ Q+ Sbjct: 245 EITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQI 304 Query: 354 EYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413 L+ V+ ETLRL P I L R K + E+ G I +G +V + P+ + +P + Sbjct: 305 PQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHD 364 Query: 414 FRPERFS--KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 471 F P R+ +++D ++ + + PFG G C+G FA+M +K +L+ + F+ + + Sbjct: 365 FVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPE 424 Query: 472 IPLKLDTQGLLQPEKPIVLKVDSRDGT 498 ++ ++Q +P ++ R G Sbjct: 425 SYRNDHSKMVVQLAQPAAVRYRRRTGV 451 >3MZS-A nrPDB Length = 486 Score = 97.8 bits (242), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 63/189 (33%), Positives = 100/189 (52%), Gaps = 8/189 (4%) Query: 305 AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM-EYLDMVVNET 363 G TTS L + LYE+A +VQ+ L++E+ +A ++QM L + ET Sbjct: 287 GGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNAR-RQAEGDISKMLQMVPLLKASIKET 345 Query: 364 LRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKK 423 LRL P+++ L+R + D+ + IP ++V + YA+ DP +++ P++F P R+ K Sbjct: 346 LRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKD 405 Query: 424 DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT--QGL 481 + + FG G R C+G R A + M L LI +L+NF E Q +DT + Sbjct: 406 KDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKV----EMQHIGDVDTIFNLI 461 Query: 482 LQPEKPIVL 490 L P+KPI L Sbjct: 462 LTPDKPIFL 470 >6AYB-A nrPDB Length = 466 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 56/192 (29%), Positives = 103/192 (53%), Gaps = 1/192 (0%) Query: 275 MIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKE 334 ++D +++ + + L+D+ I +FAG T+S S+TL + ++ V +K++KE Sbjct: 238 VVDHLLTQKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKE 297 Query: 335 IDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMV 394 + ++ + YD V++M+YL+ + E LR++P I + R +K E IPKG+++ Sbjct: 298 QEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQYIIPKGNIL 357 Query: 395 VIPTYALHHDPKYWTEPEEFRPERFSKKKDSID-PYIYTPFGTGPRNCIGMRFALMNMKL 453 V+ +T P+ F PER +++K+ Y PFG G CIG FAL+ +K Sbjct: 358 VVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHKCIGENFALLQVKS 417 Query: 454 ALIRVLQNFSFK 465 + +L+ F + Sbjct: 418 IISILLRYFDME 429 >3TBG-A nrPDB Length = 479 Score = 95.1 bits (235), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 75/277 (27%), Positives = 119/277 (42%), Gaps = 28/277 (10%) Query: 212 KFGFLDPLFLSIILFP---------FLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLN 262 +F + DP FL ++ FL V A+ V L I L+ V R +K+ L Sbjct: 172 RFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH----IPALAGKVLRFQKAFLT 227 Query: 263 DKQK----HRL---------DFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYET 309 + HR+ D + + + + +D L AG T Sbjct: 228 QLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVT 287 Query: 310 TSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP- 368 TS+ L++ L + HPDVQ+++Q+EID V+ P M Y V++E R Sbjct: 288 TSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDI 347 Query: 369 VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SKKKDSID 427 V + + +D+E+ G IPKG+ ++ ++ D W +P F PE F + + Sbjct: 348 VPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVK 407 Query: 428 PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 464 P + PF G R C+G A M + L +LQ+FSF Sbjct: 408 PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF 444 >6M7X-A nrPDB Length = 484 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 52/156 (33%), Positives = 82/156 (52%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 LS + A S+ +TT L TL+ELA +P+VQQ L++E A + + A Sbjct: 276 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 335 Query: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 ++ L + ETLRL+PV + LER D+ + IP G++V + Y+L +P + Sbjct: 336 TTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFP 395 Query: 410 EPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMR 445 PE + P+R+ + S + + PFG G R C+G R Sbjct: 396 RPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRR 431 >4ZGX-A nrPDB Length = 489 Score = 92.4 bits (228), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 52/156 (33%), Positives = 82/156 (52%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 LS + A S+ +TT+ L TL+ELA +PDVQQ L++E A + + A Sbjct: 276 LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKA 335 Query: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 ++ L + ETLRL+PV + LER D+ + IP G++V + Y+L + + Sbjct: 336 TTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFP 395 Query: 410 EPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMR 445 PE + P+R+ + S + + PFG G R C+G R Sbjct: 396 RPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRR 431 >3EL3-A nrPDB Length = 467 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 92/443 (20%), Positives = 181/443 (40%), Gaps = 60/443 (13%) Query: 44 LPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFT 103 +PLLG+ + F ++ + +G + G V A+T+P++ + + Y + Sbjct: 31 VPLLGHGWRLARDPLAFMSQL-RDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHI-- 87 Query: 104 NRRSLGPV-----GFM-KSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLV 157 GP+ G + K ++ A +R R + P F + PI+ + L Sbjct: 88 ----AGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALT 143 Query: 158 RNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLD 217 E+ +P D T SF V + + + L+ ++D Sbjct: 144 -------ERWQPGKTVDA---------TSESFRVAVRV----------AARCLLRGQYMD 177 Query: 218 PLF--LSIILFPFLTPVFEALNVSLFP------------KDTINFLSKSVNRMKKSRLND 263 L + L ++ + V L P D + L V+ + R Sbjct: 178 ERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRAS 237 Query: 264 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT 323 QK D L ++++++ ++ + + E+ Q + + G ET +S + + L LA Sbjct: 238 GQKPD-DLLTALLEAKD----DNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALAD 292 Query: 324 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 383 HP+ +++ E++AV + P ++ V ++ + V+ E +RL P L R + E+ Sbjct: 293 HPEHADRIRDEVEAVTGGR-PVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESEL 351 Query: 384 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SKKKDSIDPYIYTPFGTGPRNCI 442 G IP G+ ++ YA+ DPK + + EF P+R+ ++ ++ Y PF G R C Sbjct: 352 GGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCP 411 Query: 443 GMRFALMNMKLALIRVLQNFSFK 465 F++ + L + + F+ Sbjct: 412 SDHFSMAQLTLITAALATKYRFE 434 >3JUS-A nrPDB Length = 461 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 103/458 (22%), Positives = 183/458 (39%), Gaps = 37/458 (8%) Query: 42 TPLPLLGNVLSYRQGLWKFDTECYKKYGKMWG--------TYEGQLPVLAITDPDVIRTV 93 +P+P LG+ +++ + +F Y+KYG ++ TY A+ + Sbjct: 18 SPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDL 77 Query: 94 LVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYG 153 ++ YS T PV F K + + + +L K+ II + Sbjct: 78 NAEDVYSRLTT-----PV-FGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKET 131 Query: 154 DVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKF 213 + EK ++F A S +I S ++ + + + V L Sbjct: 132 KEYFESWGESGEK-------NVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDG 184 Query: 214 GFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQ 273 GF +L P P F + + ++ + K++ + ++S Q+ D LQ Sbjct: 185 GFSHAAWLLPGWLPL--PSFRRRDRA--HREIKDIFYKAIQKRRQS-----QEKIDDILQ 235 Query: 274 LMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQK 333 ++D+ + + L+D E+A I + AG T+S+ ++ + LA +Q+K Sbjct: 236 TLLDAT----YKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYL 291 Query: 334 EIDAVLPNKAPP-TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGS 392 E V PP TYD + + LD + ETLRL P + + R + + G IP G Sbjct: 292 EQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGH 351 Query: 393 MVVIPTYALHHDPKYWTEPEEFRPERFSKKK-DSIDPYIYTPFGTGPRNCIGMRFALMNM 451 V + W E +F P+R+ + S + + Y PFG G CIG FA + + Sbjct: 352 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQI 411 Query: 452 KLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIV 489 K +L+ + F + P T + PE P++ Sbjct: 412 KTIWSTMLRLYEFD-LIDGYFPTVNYTTMIHTPENPVI 448 >6IQ5-A nrPDB Length = 463 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 101/431 (23%), Positives = 183/431 (42%), Gaps = 46/431 (10%) Query: 66 KKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA---E 122 ++YG ++ G P++ + I LV++ S F +R S + S+A Sbjct: 12 RRYGDVFQIRLGSCPIVVLNGERAIHQALVQQG-SAFADRPSFASFRVVSGGRSMAFGHY 70 Query: 123 DEEWKRIR----SLLSPTFT----SGKLKEMFPIIAQYGDVLVRNLRREAEKG----KPV 170 E WK R S++ FT S ++ E ++++ +++ +R A+ +P+ Sbjct: 71 SEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGH-VLSEARELVALLVRGSADGAFLDPRPL 129 Query: 171 TLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFL- 229 T+ + +V++ FG S ++P+ F E +FG + + P+L Sbjct: 130 TVVAV-----ANVMSAVCFGCRY-SHDDPE--FRELLSHNEEFGRTVGAGSLVDVMPWLQ 181 Query: 230 ---TPV------FEALNVSLFPKDTINF-LSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQ 279 PV FE LN ++ NF L K + + R + +D L + + Sbjct: 182 YFPNPVRTVFREFEQLN-----RNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKK 236 Query: 280 NSKETESHKALSDLELAAQSIIFIF-AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAV 338 + ++ A DLE +I IF A +T S+ L + L +PDVQ ++Q E+D V Sbjct: 237 AAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQV 296 Query: 339 LPNKAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEINGVFIPKGSMVVIP 397 + P + Y+ + E +R V + + + + G IPK ++V + Sbjct: 297 VGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVN 356 Query: 398 TYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTP---FGTGPRNCIGMRFALMNMKLA 454 ++++HDP W PE F P RF K I+ + + F G R CIG + M + L Sbjct: 357 QWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLF 416 Query: 455 LIRVLQNFSFK 465 + + F+ Sbjct: 417 ISILAHQCDFR 427 >3S79-A nrPDB Length = 503 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 106/447 (23%), Positives = 200/447 (44%), Gaps = 51/447 (11%) Query: 38 IPGPTPLPLLGNVLSYRQGLW-------KFDTECYKKYGKMWGTYEGQLPVLAITDPDVI 90 IPGP +G ++S+ + LW + Y ++ ++W + E L I+ + Sbjct: 47 IPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGE---ETLIISKSSSM 103 Query: 91 RTVLVKECYSV-FTNRRSLGPVGFMKSAISLAEDEE-WKRIRSLLSPTFTSGKLKEMFPI 148 ++ YS F ++ L +G + I + E WK R + L M + Sbjct: 104 FHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTV 163 Query: 149 IAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNP--QDPFVES 206 A+ +L+ ++ + VT + + +DV+T V +D+ N + P ES Sbjct: 164 CAE-------SLKTHLDRLEEVTNESGY----VDVLTLLR-RVMLDTSNTLFLRIPLDES 211 Query: 207 TKKFLKFGFLDP---LFLSIILFPFLTPVFEALNVSLFP-KDTINFLSKSVNRMKKSRLN 262 G+ D L + +F ++ +++ S+ KD I L K+ R++ Sbjct: 212 AIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAE----KRRRIS 267 Query: 263 DKQK--HRLDFL-QLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLY 319 ++K +DF +L++ + T + LE+ + A +T S L F L+ Sbjct: 268 TEEKLEECMDFATELILAEKRGDLTRENVNQCILEM-------LIAAPDTMSVSLFFMLF 320 Query: 320 ELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKK 379 +A HP+V++ + KEI V+ + D + +++ ++ + E++R PV + R + Sbjct: 321 LIAKHPNVEEAIIKEIQTVIGERDIKI-DDIQKLKVMENFIYESMRYQPVVDLVMRKALE 379 Query: 380 DVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFGTGP 438 D I+G + KG+ +++ +H +++ +P EF E F+K PY Y PFG GP Sbjct: 380 DDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNV----PYRYFQPFGFGP 434 Query: 439 RNCIGMRFALMNMKLALIRVLQNFSFK 465 R C G A++ MK L+ +L+ F K Sbjct: 435 RGCAGKYIAMVMMKAILVTLLRRFHVK 461 >2WX2-A nrPDB Length = 473 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 51/180 (28%), Positives = 87/180 (48%), Gaps = 13/180 (7%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQ---KLQKEIDAVLPNKAPPT 346 +S E+ + +FAG T++ S+++ L HP ++ KL KEID A Sbjct: 262 MSLHEVCGMIVAAMFAGQHTSTITTSWSMLHL-MHPKNKKWLDKLHKEIDEF---PAQLN 317 Query: 347 YDAVV-QMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDP 405 YD V+ +M + + V E++R P + + R K +V++ +PKG ++ HHD Sbjct: 318 YDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDE 377 Query: 406 KYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK 465 + + P + PER K + + FG G CIG +FAL+ +K L + + F+ Sbjct: 378 EAFPNPRLWDPERDEKVDGA-----FIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQ 432 >6B11-A nrPDB Length = 440 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 55/222 (24%), Positives = 98/222 (44%), Gaps = 39/222 (17%) Query: 270 DFLQLMIDSQNSKET-----------ESHKALSDLELAAQSIIFIFAGYETTSSVLSFTL 318 D+L +I + +E+ LS ++ +++ + AG+ETT+S+++ ++ Sbjct: 233 DYLDRLISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSV 292 Query: 319 YELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCK 378 L HP ++L V L V+E LR +A L R+ Sbjct: 293 LVLLQHPTAWREL------------------TVNPGLLPGAVDELLRYLSIADGLRRSAT 334 Query: 379 KDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGP 438 D+EI+G I G +V A + D ++EPE F R +++ + FG GP Sbjct: 335 ADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSARR--------HVAFGYGP 386 Query: 439 RNCIGMRFALMNMKLALIRVLQNF-SFKPCKETQ-IPLKLDT 478 C+G A M +++AL VL+ + +P + + LK D+ Sbjct: 387 HQCLGQNLARMELEVALGAVLERLPALRPTTDVAGLRLKSDS 428 >3L4D-A nrPDB Length = 453 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 57/227 (25%), Positives = 98/227 (43%), Gaps = 28/227 (12%) Query: 260 RLNDKQKHRLDFLQLMIDSQNSKETESHKALSDL------------------ELAAQSII 301 R D + D L +I ++ +E + SDL E+ + Sbjct: 200 RCRDARAELQDILSEIIIAREKEEAQKDTNTSDLLAGLLGAVYRDGTRMSQHEVCGMIVA 259 Query: 302 FIFAGYETTSSVLSFTLYELATHPDVQQ--KLQKEIDAVLPNKAPPTYDAVVQ-MEYLDM 358 +FAG T++ +++L L + + KL +EID A YD V++ M + + Sbjct: 260 AMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEIDEF---PAQLNYDNVMEEMPFAEQ 316 Query: 359 VVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418 E++R P + L R K V++ +P+G ++ H D + + P E+ PER Sbjct: 317 CARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPER 376 Query: 419 FSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK 465 K D + FG G CIG +F L+ +K L VL+++ F+ Sbjct: 377 NMKLVDG----AFCGFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFE 419 >2X2N-A nrPDB Length = 475 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 47/179 (26%), Positives = 87/179 (48%), Gaps = 11/179 (6%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQ--QKLQKEIDAVLPNKAPPTY 347 +S E+ + +FAG T+S ++++ L +V+ + L+KEI+ A Y Sbjct: 262 MSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEF---PAQLNY 318 Query: 348 DAVV-QMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPK 406 + V+ +M + + E++R P + L R DV++ +PKG ++ HHD + Sbjct: 319 NNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEE 378 Query: 407 YWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK 465 + EP + PER K + + + FG G CIG +F L+ +K L +++ F+ Sbjct: 379 AFPEPRRWDPERDEKVEGA-----FIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQ 432 >3P3Z-A nrPDB Length = 416 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 50/167 (29%), Positives = 77/167 (46%), Gaps = 26/167 (15%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 L D EL + AGYETT+ L+ +Y+ A HPD K+++ P AP Sbjct: 238 LDDYELRTLVATVLVAGYETTNHQLALAMYDFAQHPDQWMKIKEN-----PELAP----- 287 Query: 350 VVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 V E LR P + + R +D E+NGV IP G+ V + + H DP+ + Sbjct: 288 --------QAVEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVF 339 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL 455 + + F + K+++ P I FG GP C+G A + + A+ Sbjct: 340 ADADRF---DITVKREA--PSIA--FGGGPHFCLGTALARLELTEAV 379 >6CR2-A nrPDB Length = 477 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 53/196 (27%), Positives = 89/196 (45%), Gaps = 24/196 (12%) Query: 292 DLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP-TYDAV 350 D E+A I + AG ++SS S+ + LAT PD+ ++L +E VL + PP TYD + Sbjct: 248 DEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNL 307 Query: 351 VQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGV--FIPKGSMVVIPTYALHHDPKYW 408 +++ V+ ETLRL + R K + ++G IP V+ +++ Sbjct: 308 QKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHF 367 Query: 409 TEPEEFRPERFSKK-------------------KDSIDPYIYTPFGTGPRNCIGMRFALM 449 P E+ P R+ + K + PY+ PFG G CIG +FA + Sbjct: 368 PNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYL--PFGAGRHRCIGEQFAYL 425 Query: 450 NMKLALIRVLQNFSFK 465 + +++ F F+ Sbjct: 426 QLGTITAVLVRLFRFR 441 >4WMZ-A nrPDB Length = 539 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 94/213 (44%), Gaps = 30/213 (14%) Query: 275 MIDS--QNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQ 332 +IDS +NS + K ++D E+A I + G T+++ ++ L LA PDVQQ+L Sbjct: 283 LIDSLMKNSTYKDGVK-MTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELY 341 Query: 333 KEIDAVLP-NKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI--NGVFIP 389 +E VL K TYD + +M L+ + ETLR+ L R KD+ + IP Sbjct: 342 EEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIP 401 Query: 390 KGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI------------------- 430 G V++ H +Y+ +F R++ DS Y Sbjct: 402 AGYHVLVSPGYTHLRDEYFPNAHQFNIHRWN--NDSASSYSVGEEVDYGFGAISKGVSSP 459 Query: 431 YTPFGTGPRNCIGMRFALMNMKLAL---IRVLQ 460 Y PFG G CIG FA + + + IR L+ Sbjct: 460 YLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLK 492 >5JLC-A nrPDB Length = 515 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 66/264 (25%), Positives = 115/264 (43%), Gaps = 30/264 (11%) Query: 256 MKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLS 315 +K+ R + ++R +LM +S T+ ++D E+A I + G T+++ + Sbjct: 251 IKERREKNDIQNRDLIDELMKNSTYKDGTK----MTDQEIANLLIGVLMGGQHTSAATSA 306 Query: 316 FTLYELATHPDVQQKLQKEIDAVLPNKAPP-TYDAVVQMEYLDMVVNETLRLFPVAIRLE 374 + L LA PDVQ++L +E VL N TYD + M L+ ++ ETLRL L Sbjct: 307 WCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLF 366 Query: 375 RTCKKDVEI--NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF--------SKKKD 424 R +DV I +P+ V++ H +++ +P EF R+ + D Sbjct: 367 RKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGD 426 Query: 425 SID------------PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK-PCKETQ 471 +D PY+ PFG G CIG FA + + + ++ ++ P + Sbjct: 427 EVDYGFGAISKGVSSPYL--PFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGET 484 Query: 472 IPLKLDTQGLLQPEKPIVLKVDSR 495 +P T + P P + + R Sbjct: 485 VPPSDFTSMVTLPTAPAKIYWEKR 508 >4OQR-A nrPDB Length = 457 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 30/174 (17%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 L+D EL ++I + AG+ETT+++L + L HP+ L + DA Sbjct: 264 LTDEELTNIALILLVAGHETTANMLGLGTFALLQHPEQIANLD-------------SPDA 310 Query: 350 VVQM-EYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 V ++ YL +V T R +DVE+ G I KG V I A++ DPK + Sbjct: 311 VEELLRYLSIVHLGTP---------NRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVF 361 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 EP+ + +R +K + FG G C+G + A + M++ R+ F Sbjct: 362 DEPDILQLDRVDARK-------HAAFGGGIHQCLGQQLARVEMRIGFTRLFARF 408 >1Z8P-A nrPDB Length = 404 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 58/220 (26%), Positives = 96/220 (43%), Gaps = 37/220 (16%) Query: 243 KDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIF 302 ++ +NF+ V R +++ D D L +I Q+ + LS EL + +++ Sbjct: 190 REVVNFILDLVER-RRTEPGD------DLLSALIRVQDDDDGR----LSADELTSIALVL 238 Query: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362 + AG+E++ S++ Y L THPD Q L + + LPN V E Sbjct: 239 LLAGFESSVSLIGIGTYLLLTHPD-QLALVRRDPSALPN-----------------AVEE 280 Query: 363 TLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422 LR R ++VEI GV IP+ S V++ A + DPK + +P F R ++ Sbjct: 281 ILRYIAPPETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFDVTRDTRG 340 Query: 423 KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 + FG G C+G A + ++AL + F Sbjct: 341 --------HLSFGQGIHFCMGRPLAKLEGEVALRALFGRF 372 >2Z36-A nrPDB Length = 413 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 52/221 (23%), Positives = 95/221 (42%), Gaps = 41/221 (18%) Query: 248 FLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQ--------- 298 F S++ + ++ + D+++ + + D KE+E L ++A Q Sbjct: 174 FQSRTTMMVSRTSMEDRRRAFAELRAYIDDLITRKESEPGDDLFSRQIARQRQEGTLDHA 233 Query: 299 -----SIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353 + + + AG+ETT++++S + L +HP+ Q + P + P Sbjct: 234 GLVSLAFLLLTAGHETTANMISLGVVGLLSHPE-----QLTVVKANPGRTP--------- 279 Query: 354 EYLDMVVNETLRLFPVAIRL-ERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPE 412 M V E LR F +A + R +DVEI GV I G V++ + + DP + +P Sbjct: 280 ----MAVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPA 335 Query: 413 EFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKL 453 ER ++ + FG GP C+G A M +++ Sbjct: 336 VLDVERGARH--------HLAFGFGPHQCLGQNLARMELQI 368 >4OQS-A nrPDB Length = 433 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 48/174 (27%), Positives = 79/174 (45%), Gaps = 30/174 (17%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 L+D EL +++ + AG+ETT+++L + L HP+ L + DA Sbjct: 225 LTDEELTNIALLLLVAGHETTANMLGLGTFALLQHPEQIAALD-------------SPDA 271 Query: 350 VVQM-EYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 V ++ YL +V T R +DVE+ G I KG V I A++ DPK + Sbjct: 272 VEELLRYLSIVHLGTP---------NRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVF 322 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 EP+ + +R +K + FG G C+G + A + M++ R+ F Sbjct: 323 DEPDILQLDRVDARK-------HAAFGGGIHQCLGQQLARVEMRIGFTRLFARF 369 >1WIY-A nrPDB Length = 389 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 51/191 (26%), Positives = 86/191 (45%), Gaps = 27/191 (14%) Query: 282 KETES---HKALSDL---ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEI 335 +E E+ H LS L ++++ + AG+ET +S L+++ L+ PD Q+++ Sbjct: 192 REAEALIVHPPLSHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRV---- 247 Query: 336 DAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVV 395 E E LRL+P A L R ++ + + +P+G+ +V Sbjct: 248 --------------AESEEAALAAFQEALRLYPPAWILTRRLERPLLLGEDRLPQGTTLV 293 Query: 396 IPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL 455 + Y Y+ E E F+PERF ++ + Y PFG G R C+G FAL+ + L Sbjct: 294 LSPYVTQR--LYFPEGEAFQPERFLAERGTPSGR-YFPFGLGQRLCLGRDFALLEGPIVL 350 Query: 456 IRVLQNFSFKP 466 + F P Sbjct: 351 RAFFRRFRLDP 361 >5XNT-A nrPDB Length = 411 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 88/351 (25%), Positives = 141/351 (40%), Gaps = 62/351 (17%) Query: 115 KSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKD 174 K I+ A+ E ++ RSLL+ FT L+ P I + D L+ + E E +L Sbjct: 85 KIKITEADPPEHRKRRSLLAAAFTPRSLQNWEPRIQEIADELIEEMDEETEIDIVQSLAS 144 Query: 175 IFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFE 234 M + G V S + L ++D LFL PF E Sbjct: 145 PLPIIVMSDLMG-----------------VPSKDRLLFKKWVDILFL-----PFDKEKQE 182 Query: 235 ALNV--SLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSD 292 +N + K+ +L V + RLN D L+ +D + +D Sbjct: 183 EVNELKQVAAKEYYQYLYPIV---VQKRLNPADDIISDLLKAEVDGE---------MFTD 230 Query: 293 LELAAQSIIFIFAGYETTSSVLSFTLYELA-THPDVQQKLQKEIDAVLPNKAPPTYDAVV 351 E+ +++ + AG ETTS +L+ + Y L +V Q+L + +D V Sbjct: 231 DEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLV------------- 277 Query: 352 QMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEP 411 V E LR I+L+RT K+D ++ GV + +G VV+ A + D + + + Sbjct: 278 -----PQAVEEMLRYRFNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDA 332 Query: 412 EEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 R + KK + FG GP C+G A + K+AL L+ F Sbjct: 333 FTLNIHRPNNKK-------HLTFGNGPHFCLGAPLARLEAKIALTTFLKKF 376 >4YT3-A nrPDB Length = 410 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 93/407 (22%), Positives = 163/407 (40%), Gaps = 68/407 (16%) Query: 61 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL 120 D Y + W ++ + ++D +V + SV T+ G + I + Sbjct: 33 DPVSYHEGTDTWNVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEE----GSVPEKIQI 88 Query: 121 AEDE--EWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGA 178 E + + ++ RSLL+ FT L+ P I + D L+ + G Sbjct: 89 TESDPPDHRKRRSLLAAAFTPRSLQNWEPRIQEIADELIGQMD---------------GG 133 Query: 179 YSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNV 238 +D++ + + I + + V S + L ++D LFL PF E ++ Sbjct: 134 TEIDIVASLASPLPIIVMADLMG--VPSKDRLLFKKWVDTLFL-----PFDREKQEEVDK 186 Query: 239 --SLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELA 296 + K+ +L V + RLN D L+ +D + +D E+ Sbjct: 187 LKQVAAKEYYQYLYPIV---VQKRLNPADDIISDLLKSEVDGE---------MFTDDEVV 234 Query: 297 AQSIIFIFAGYETTSSVLSFTLYELA-THPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEY 355 +++ + AG ETTS +L+ + Y L +V Q+L + +D V Sbjct: 235 RTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLV----------------- 277 Query: 356 LDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFR 415 V E LR I+L+RT K+D ++ GV + +G VV+ A + D + + +P Sbjct: 278 -PQAVEEMLRFRFNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLN 336 Query: 416 PERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 R + KK + FG GP C+G A + K+AL L+ F Sbjct: 337 IHRPNNKK-------HLTFGNGPHFCLGAPLARLEAKIALTAFLKKF 376 >5L94-A nrPDB Length = 410 Score = 64.7 bits (156), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 52/195 (26%), Positives = 84/195 (43%), Gaps = 35/195 (17%) Query: 285 ESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAP 344 E K L+D E+ SI+ + AG ETT++++S T+Y L ++L++E Sbjct: 222 EEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIYCLMEDKASFERLKRE---------- 271 Query: 345 PTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHD 404 E L + E LR L R K+DV + G + G VV + H D Sbjct: 272 --------KELLPSGIEEVLRYRSPVQALHRIVKEDVTLAGKKLKAGEHVVPWMGSAHRD 323 Query: 405 PKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQ---- 460 +Y+ +PE F+ +R P ++ FG G C+G A + K+ L ++ Sbjct: 324 AEYFEDPEVFKIDR--------KPNVHMAFGRGIHFCLGAPLARIEAKIMLAELIDRYPQ 375 Query: 461 -----NFSFKPCKET 470 +F KP + T Sbjct: 376 MDWSPSFELKPIEST 390 >4GGV-A nrPDB Length = 418 Score = 64.7 bits (156), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 52/220 (23%), Positives = 95/220 (43%), Gaps = 31/220 (14%) Query: 243 KDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIF 302 +D L ++ M ++ R D L ++ ++ E L+D E+ + I Sbjct: 200 RDATERLRPLLDYMAGHVTERRRTPREDLLTHLVQAEVDGER-----LTDNEIVNVANIL 254 Query: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362 + G+ TT+ L T+ L P+V K++ + +++P + E Sbjct: 255 LVTGHITTTMTLGNTVLCLDADPEVAAKVRAD-RSLVPG-----------------AIEE 296 Query: 363 TLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422 LR+ + L R ++VE+ G IPK +V++ A + DP+ +T+PE + P R Sbjct: 297 ALRVLSPSAALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTR---- 352 Query: 423 KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 DP + FG G C+G A + ++AL + F Sbjct: 353 ----DPNPHFGFGRGIHFCLGAPLARLEGRVALNALFDRF 388 >3AWQ-A nrPDB Length = 415 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 36/109 (33%), Positives = 52/109 (47%), Gaps = 6/109 (5%) Query: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 V Q +Y ++ V E R +P + +D E G+ P+G VV+ Y +HD W Sbjct: 268 VQQPDYAELFVQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWA 327 Query: 410 EPEEFRPERFSKKKDSIDPYIYTPFGTGP----RNCIGMRFALMNMKLA 454 +P+EFRPERF + D + + P G G C G L MK+A Sbjct: 328 DPQEFRPERFRAWDE--DSFNFIPQGGGDHYLGHRCPGEWIVLAIMKVA 374 >5CJE-A nrPDB Length = 393 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/179 (28%), Positives = 74/179 (41%), Gaps = 27/179 (15%) Query: 284 TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKA 343 E LS EL A + I + AG+ETT ++++ ++ L THPD L+ + Sbjct: 212 AEDDDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRAD--------- 262 Query: 344 PPTYDAVVQMEYLDMVVNETLRL-FPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALH 402 M LD V E LR PV R + +EI G I +G V+I A Sbjct: 263 ---------MTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAG 313 Query: 403 HDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN 461 DP +P F R P + FG G C+G A + ++AL +L+ Sbjct: 314 RDPARHPDPHVFDIHRA--------PQGHLAFGHGIHYCLGAPLARLEARVALRSLLER 364 >3OFT-A nrPDB Length = 396 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 40/150 (26%), Positives = 69/150 (46%), Gaps = 25/150 (16%) Query: 302 FIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVN 361 +F G +T ++++ LA HP+ Q+ L++ D ++P A + Sbjct: 231 LLFGGLDTVAAMIGMVALHLARHPEDQRLLRERPD-LIPAAA-----------------D 272 Query: 362 ETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421 E +R +P + + R DV+ +GV I KG +V +P+ + DP + PEE R +R Sbjct: 273 ELMRRYPT-VAVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDR--- 328 Query: 422 KKDSIDPYIYTPFGTGPRNCIGMRFALMNM 451 + P +T G G C+G A M + Sbjct: 329 ---GLAPIRHTTMGVGAHRCVGAGLARMEV 355 >2VZM-A nrPDB Length = 436 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 91/206 (44%), Gaps = 33/206 (16%) Query: 259 SRLNDKQKHR--LDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSF 316 SRL D ++ + D L ++ + + E L+ EL + I + AG+ETT ++++ Sbjct: 219 SRLIDSKRGQDGEDLLSALVRTSD----EDGSRLTSEELLGMAHILLVAGHETTVNLIAN 274 Query: 317 TLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL-FPVAIRLER 375 +Y L +HPD L+ + M LD V E LR PV R Sbjct: 275 GMYALLSHPDQLAALRAD------------------MTLLDGAVEEMLRYEGPVESATYR 316 Query: 376 TCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFG 435 + V+++G IP G V++ H P+ + + P RF ++D+ + FG Sbjct: 317 FPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPD-----PHRFDIRRDTAG---HLAFG 368 Query: 436 TGPRNCIGMRFALMNMKLALIRVLQN 461 G CIG A + ++A+ +L+ Sbjct: 369 HGIHFCIGAPLARLEARIAVRALLER 394 >4UBS-A nrPDB Length = 393 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 48/208 (23%), Positives = 84/208 (40%), Gaps = 37/208 (17%) Query: 259 SRLNDKQKHRLDFLQLMIDSQNS-----------KETESHKALSDLELAAQSIIFIFAGY 307 + + D + D+L +ID + +E + + EL + + + + AG+ Sbjct: 175 AEVQDARAQLDDYLYALIDRKRKEPGDGLLDDLIQEQLNRGTVDRAELVSLATLLLIAGH 234 Query: 308 ETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF 367 ETT++++S + L HP+ +L+ E P P V E LR Sbjct: 235 ETTANMISLGTFTLLRHPEQLAELRAE-----PGLMP-------------AAVEELLRFL 276 Query: 368 PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID 427 +A L R +D+E+ G I VV T ++ D + EP+ R ++ Sbjct: 277 SIADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHRSARH----- 331 Query: 428 PYIYTPFGTGPRNCIGMRFALMNMKLAL 455 + FG G C+G A M++AL Sbjct: 332 ---HVAFGFGIHQCLGQNLARAEMEIAL 356 >4Z5P-A nrPDB Length = 400 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 49/195 (25%), Positives = 90/195 (46%), Gaps = 33/195 (16%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQ 329 D L +++ +++ + L++ EL + + AG+ET++ L +Y L TH D Q Sbjct: 207 DLLGVLVSARDDDDR-----LTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHED-QL 260 Query: 330 KLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPV--AIRLERTCKKDVEINGVF 387 L +E Q E L V E LR P+ + R +DVE++G Sbjct: 261 SLLRE-----------------QPELLPRAVEELLRFVPLGNGVGNARIALEDVELSGGT 303 Query: 388 IPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFA 447 + G VV + DP+ + +P+ +++K +P++ FG G C+G + A Sbjct: 304 VRAGEGVVAAAVNANRDPRAFDDPDRL---DITREK---NPHL--AFGHGAHYCLGAQLA 355 Query: 448 LMNMKLALIRVLQNF 462 M +++A+ +L+ F Sbjct: 356 RMELRVAIGGLLERF 370 >5FSA-A nrPDB Length = 490 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 88/205 (42%), Gaps = 33/205 (16%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP---- 345 ++D E+A I + G T++S ++ L L P +Q + +E+ +L K Sbjct: 250 MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDL 309 Query: 346 TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI--NGVFIPKGSMVVI-PTYALH 402 TY+ + ++ ++ + ETLR+ + R + I +PKG V++ P YA H Sbjct: 310 TYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYA-H 368 Query: 403 HDPKYWTEPEEFRPERFS-----------KKKDSID------------PYIYTPFGTGPR 439 +Y+ PE+F P R+ D +D PY+ PFG G Sbjct: 369 TSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYL--PFGGGRH 426 Query: 440 NCIGMRFALMNMKLALIRVLQNFSF 464 CIG +FA + + L + N + Sbjct: 427 RCIGEQFAYVQLGTILTTFVYNLRW 451 >2ZQJ-A nrPDB Length = 417 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 34/103 (33%), Positives = 52/103 (50%), Gaps = 6/103 (5%) Query: 357 DMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRP 416 +M V E R +P L KKD N KG+ V++ Y +HDP+ W P+EFRP Sbjct: 277 EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRP 336 Query: 417 ERFSKKKDSIDPYIYTPFGTGP----RNCIGMRFALMNMKLAL 455 ERF+++++++ + P G G C G + MK +L Sbjct: 337 ERFAEREENL--FDMIPQGGGHAEKGHRCPGEGITIEVMKASL 377 >4RM4-A nrPDB Length = 396 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 49/204 (24%), Positives = 82/204 (40%), Gaps = 31/204 (15%) Query: 264 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT 323 + K D + ++++++ + E LS EL + + AG ETT++++S +Y + Sbjct: 203 RNKPEQDIISILVEAEETGEK-----LSGEELIPFCTLLLVAGNETTTNLISNAMYSILE 257 Query: 324 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 383 P V ++L+ E + V E LR A L R K+D EI Sbjct: 258 TPGVYEELRS------------------HPELMPQAVEEALRFRAPAPVLRRIAKRDTEI 299 Query: 384 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG 443 G I +G MV+ + + D + P F R P + FG G C+G Sbjct: 300 GGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRRH--------PNPHIAFGHGIHFCLG 351 Query: 444 MRFALMNMKLALIRVLQNFSFKPC 467 A + +AL ++ F C Sbjct: 352 APLARLEANIALTSLISAFPHMEC 375 >3ABB-A nrPDB Length = 408 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 50/200 (25%), Positives = 85/200 (42%), Gaps = 32/200 (16%) Query: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353 E+ +++ + AG+ETT + ++ L HP+ +ID +L + P VV+ Sbjct: 232 EVVMIALVLLVAGHETTVNAIALGALTLIQHPE-------QIDVLL--RDPGAVSGVVE- 281 Query: 354 EYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413 E LR V+ + R K+D+E+ G I G V++ ++ D K + P+ Sbjct: 282 --------ELLRFTSVSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDI 333 Query: 414 FRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL----IRVLQNFSFKPCKE 469 F R ++ + FG G C+G A +++AL R+ P E Sbjct: 334 FDARRNARH--------HVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLAVPLDE 385 Query: 470 TQIPLKLDTQGLLQPEKPIV 489 I D QG + E P+V Sbjct: 386 VPIKAGHDAQGPI--ELPVV 403 >5VWS-A nrPDB Length = 393 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 89/393 (22%), Positives = 158/393 (40%), Gaps = 65/393 (16%) Query: 75 YEGQLPVLAITDPDVIRTVLVKECYSVFTNRRS-LGPV--GFMKSAISLAEDEEWKRIRS 131 + Q + + D +R +L Y F++ R+ L P GF K I++ + E + R Sbjct: 34 WRDQFGIYHVFRYDDVRQILGD--YQTFSSDRTRLMPTAQGFGKGGITMIDPPEHRHQRR 91 Query: 132 LLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGV 191 L++ FT + M P I Q D L+ L G L + F AY + VI V Sbjct: 92 LITHAFTPQSISAMEPRIRQIADHLLDEL-----PGPEFDLVEHF-AYPLPVI------V 139 Query: 192 NIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSK 251 + L P + L + D L +S+ + + P T+ Sbjct: 140 IAELLGVP------PGDRHLFRTWSDRL-MSLQVENYADPEL---------ARTVAAAMT 183 Query: 252 SVNRMKKSRLNDKQKH-RLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETT 310 +N + ++ H R D L ++ + E E K L E+ + + + AG+ TT Sbjct: 184 EMNDYLREHCRSRRTHPRDDLLTRLVQA----EVEG-KRLDLEEVVNTASLLLLAGHLTT 238 Query: 311 SSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA 370 + ++ T+ L HP+ ++ ++ + P+ P + E+LRL Sbjct: 239 TVLIGNTMLCLWDHPEAEKAVRAD-----PSLIP-------------AALEESLRLRSPF 280 Query: 371 IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI 430 ++ R +DV I G IP V+ + +HD + + +PE F R + Sbjct: 281 LQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHRQTTG-------- 332 Query: 431 YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 + FG G C+G + + ++AL R+L F+ Sbjct: 333 HIAFGHGVHFCLGAQLGRLEGRIALERLLGRFT 365 >3A50-A nrPDB Length = 411 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 49/173 (28%), Positives = 81/173 (46%), Gaps = 27/173 (15%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 LS EL A +++ + AG+ETT +++ + L THPD Q+KL E +++ + Sbjct: 221 LSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPD-QRKLLAEDPSLISS-------- 271 Query: 350 VVQMEYLDMVVNETLRL-FPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 V E LR PV+ R +DV +GV IP G MV++ A + D + Sbjct: 272 ---------AVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWM 322 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN 461 E P+R +D+ FG G C+G + A + ++A+ R+ + Sbjct: 323 PE-----PDRLDITRDASGGVF---FGHGIHFCLGAQLARLEGRVAIGRLFAD 367 >3BUJ-A nrPDB Length = 397 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 85/381 (22%), Positives = 138/381 (36%), Gaps = 98/381 (25%) Query: 90 IRTVLVKECYSVFTNRR----SLGP--VGFMKSAISLAEDE-EWKRIRSLLSPTFTSGKL 142 +R VL E ++ RR +GP + + I L +DE + R+R ++ P F+ L Sbjct: 44 VRAVLGDERFARTGIRRFWTDLVGPGLLAEIVGDIILFQDEPDHGRLRGVVGPAFSPSAL 103 Query: 143 KEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDP 202 + + P+IA D L+R P + +MDV+ ++ Sbjct: 104 RRLEPVIAGTVDDLLR----------PALARG-----AMDVVDELAY------------- 135 Query: 203 FVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLN 262 PL L +L P + V + +D L + + R + Sbjct: 136 ---------------PLALRAVLGLLGLPAADWGAVGRWSRDVGRTLDRGASAEDMRRGH 180 Query: 263 DKQKHRLDF----------------LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAG 306 D+ L LM+D+ + +S E+ + + FIF G Sbjct: 181 AAIAEFADYVERALARRRREGGEDLLALMLDAHD------RGLMSRNEIVSTVVTFIFTG 234 Query: 307 YETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL 366 +ET +S + + L HPD L++ D L V E LR Sbjct: 235 HETVASQVGNAVLSLLAHPDQLDLLRRRPD------------------LLAQAVEECLRY 276 Query: 367 FPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI 426 P R DVE+ G + + +VV+ A + DP+ + P++F ER Sbjct: 277 DPSVQSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIER-------- 328 Query: 427 DPYIYTPFGTGPRNCIGMRFA 447 DP FG G R C+G A Sbjct: 329 DPVPSMSFGAGMRYCLGSYLA 349 >5OFQ-A nrPDB Length = 409 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 81/413 (19%), Positives = 165/413 (39%), Gaps = 107/413 (25%) Query: 100 SVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRN 159 S+F+++R++ + +I + + + ++R+L++ FT ++ + I + D L+ Sbjct: 68 SLFSSKRAMEE---RQESILMMDPPKHTKLRNLVNKAFTPRAIQHLEGHIEEIADYLLDE 124 Query: 160 LRREAEK--------------------GKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNP 199 + + EK G P+ + +F YS D+++G NN Sbjct: 125 VSSK-EKFDIVEDFAGPLPIIVIAELLGVPIQDRALFKKYSDDLVSGAE--------NNS 175 Query: 200 QDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKS 259 + F + +K + + FL + Sbjct: 176 DEAFAKMMQK--------------------------------RNEGVIFLQGYFKEIIAE 203 Query: 260 RLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLY 319 R +KQ+ D + L+++++ E L++ E+ I+ + AG ETT+++++ + Sbjct: 204 RQQNKQE---DLISLLLEAEIDGEH-----LTEEEVLGFCILLLVAGNETTTNLITNGVR 255 Query: 320 ELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKK 379 + DVQ +++++I +++PN +V ETLR +P + R + Sbjct: 256 YMTEDVDVQNEVRRDI-SLVPN-----------------LVEETLRYYPPIQAIGRIAAE 297 Query: 380 DVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPR 439 DVE+ I +G V+ + + D + P+ F R +P++ FG G Sbjct: 298 DVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR------KTNPHV--SFGFGIH 349 Query: 440 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKV 492 C+G A M K+A ++L+ F K+ Q L + P V V Sbjct: 350 FCLGAPLARMEGKIAFTKLLEKGGFS---------KVQNQSLKPIDSPFVFGV 393 >6DCD-A nrPDB Length = 424 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 42/163 (25%), Positives = 80/163 (49%), Gaps = 26/163 (15%) Query: 298 QSIIFIFA-GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYL 356 +S F+FA G ETT+ +L+ + L PD+Q++L +E +++PN Sbjct: 244 RSATFLFAAGQETTAKLLTAAMRVLGDRPDIQRRL-RENRSLIPN--------------- 287 Query: 357 DMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRP 416 + E+LR+ R +K + G+ I G++V++ A + DP+ + +P EFR Sbjct: 288 --FIEESLRMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRL 345 Query: 417 ERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVL 459 +R + ++ + F G +C G A + +++L R+L Sbjct: 346 DRPNVRE-------HMAFARGVHSCPGGPLARVEGRVSLERIL 381 >1Q5D-A nrPDB Length = 419 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 76/349 (21%), Positives = 146/349 (41%), Gaps = 53/349 (15%) Query: 124 EEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDV 183 E+ R+R L++P+FTS + D+L ++R ++ L G DV Sbjct: 101 EDHARVRKLVNPSFTSRAI-----------DLLRAEIQRTVDQ----LLDARSGQEEFDV 145 Query: 184 ITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPK 243 + + G+ + +++ E +KF +FG L + L P + + L S+ Sbjct: 146 VRDYAEGIPMRAISALLKVPAECDEKFRRFGSATARALGVGLVPRVDEETKTLVASV--T 203 Query: 244 DTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFI 303 + + L ++ +++ L + D L +++ ++ LS EL A I Sbjct: 204 EGLALLHGVLDERRRNPLEN------DVLTMLLQAEADGSR-----LSTKELVALVGAII 252 Query: 304 FAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNET 363 AG +TT +++F + L P+ + ++ E P D V++ + + Sbjct: 253 AAGTDTTIYLIAFAVLNLLRSPEALELVKAE-----PGLMRNALDEVLRFDNI------- 300 Query: 364 LRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKK 423 LR+ V R ++D+E G I KG MV + + D ++ RP+ F ++ Sbjct: 301 LRIGTV-----RFARQDLEYCGASIKKGEMVFLLIPSALRDGTVFS-----RPDVFDVRR 350 Query: 424 DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQI 472 D+ Y G GP C G+ A + ++A+ + + F KET + Sbjct: 351 DTSASLAY---GRGPHVCPGVSLARLEAEIAVGTIFRRFPEMKLKETPV 396 >5KYO-A nrPDB Length = 430 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 63/243 (25%), Positives = 101/243 (41%), Gaps = 42/243 (17%) Query: 261 LNDKQKHRLDFLQLMIDSQNSKETE-----------SHKALSDLELAAQSIIFIFAGYET 309 L+D K ++L+ +I+++ K E + L+D+E I + G +T Sbjct: 215 LDDVTKQFREYLRPVIEARRIKPGEDMISRMINGEVGGRPLTDIEAENICIQVLVGGLDT 274 Query: 310 TSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPV 369 ++L FT LA L++ I A P+ +D + E R FPV Sbjct: 275 VVNMLGFTFSHLAK----DHALRRAI------AADPSL--------IDDALLEFFRRFPV 316 Query: 370 AIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY 429 + R +D E GV + G MV+ PT + D +P EFR R +++ Sbjct: 317 -VSSAREVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGRKARQ------- 368 Query: 430 IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLDTQGLLQPEKPI 488 ++ FG G C G A M MK+ L F+ E PL+ + G++ KP Sbjct: 369 -HSTFGKGSHTCPGAHLARMEMKVVLREWFARIPEFR--IEDDAPLRY-SNGIVGSVKPF 424 Query: 489 VLK 491 VL+ Sbjct: 425 VLE 427 >5YHJ-A nrPDB Length = 413 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 45/171 (26%), Positives = 80/171 (46%), Gaps = 22/171 (12%) Query: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353 E+ A ++ I S + FT+ L PDV++++++ V + Sbjct: 228 EVVAVEVLNILRPTVAISVYVLFTVLALHQFPDVKEQVER--------------GEVSKT 273 Query: 354 EYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413 E+ V E R +P K D E +G P+G++ ++ Y +HD WTEP+ Sbjct: 274 EF----VQEVRRFYPFFPVAAARVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDR 329 Query: 414 FRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALI-RVLQNFS 463 F P RF K+S P+ + P G G + G R A ++ +A++ +V++ F+ Sbjct: 330 FDPSRFKDWKES--PFNFIPQGGGDVD-FGHRCAGEHVTIAILAQVIELFT 377 >5NWS-A nrPDB Length = 435 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 69/340 (20%), Positives = 136/340 (40%), Gaps = 66/340 (19%) Query: 128 RIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGT 187 R+R L++ F + ++ + P I + D L+ L R E+ V L + F AY + + Sbjct: 125 RLRRLVTRAFAARRILGLRPGIERIADRLLAELPRREEEDGTVDLLEHF-AYPLSITVIC 183 Query: 188 SF----GVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPK 243 +++ V + L+ F PV Sbjct: 184 ELVGIPATDLERWREWGGDLVSMRPERLRHSF---------------PVM---------- 218 Query: 244 DTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFI 303 I++ + + + +++ L D D L +I +Q+ + LSD+E + + Sbjct: 219 --IDYCHRLIEQ-RRAALTD------DLLSELIRAQD----DDGGRLSDIETVTMILTLV 265 Query: 304 FAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNET 363 AG+ET++ ++ L THP Q L ++ A+LP V+E Sbjct: 266 LAGHETSAHLIGNGTAALLTHPG-QWALLRKDPALLPR-----------------AVHEL 307 Query: 364 LR-LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422 +R V + R +D+E+ G + +G V + + + DP+++++P+ R + Sbjct: 308 MRWCGSVHVARLRYATEDLELAGTPVARGDAVQLVLVSANFDPRHYSDPDRLDITRHQEG 367 Query: 423 KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 + + FG G C+G A ++AL R+L+ + Sbjct: 368 QAE----NHVGFGHGIHYCLGATLARQEGEVALARLLETY 403 >6FYJ-A nrPDB Length = 421 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 44/170 (25%), Positives = 72/170 (42%), Gaps = 23/170 (13%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 L D E AA +I I + ++F L +P+ ++KL+ Sbjct: 231 LLDTETAAVEVINILRPIVAIAIFINFIALALHHYPEEKEKLKSG--------------- 275 Query: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 +Y M V E R +P + KKD G +G++ ++ Y +HDP+ W Sbjct: 276 --DKKYSQMFVQEVRRFYPFFPFVVALVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWK 333 Query: 410 EPEEFRPERFSKKKDSIDPYIYTPFGTGP----RNCIGMRFALMNMKLAL 455 P+ F P+RF+K + S P+ + P G G C G + MK++L Sbjct: 334 NPDVFSPDRFAKWEGS--PFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSL 381 >5HDI-A nrPDB Length = 404 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 43/164 (26%), Positives = 71/164 (43%), Gaps = 25/164 (15%) Query: 300 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMV 359 + AG E+T+++L ++ LAT PD+QQ++ +A P E L Sbjct: 239 VTLFAAGGESTAALLGSAVWILATRPDIQQQV----------RANP--------ELLGAF 280 Query: 360 VNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF 419 + ETLR P R + ++G +P S +++ A + DP + P EFR +R Sbjct: 281 IEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRA 340 Query: 420 SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 K + FG G C+G A + ++ L +L S Sbjct: 341 GGKG-------HISFGKGAHFCVGAALARLEARIVLRLLLDRTS 377 >3NV6-A nrPDB Length = 452 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 60/209 (28%), Positives = 92/209 (44%), Gaps = 40/209 (19%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQ 329 D + LM++S+ + E +H L +T + LSF + LA HP++ Sbjct: 260 DLITLMVNSEINGERIAHDKAQGLISLLLLGG-----LDTVVNFLSFFMIHLARHPELVA 314 Query: 330 KLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIP 389 +L+ + P K L E R FPV + R KD E GVF+ Sbjct: 315 ELRSD-----PLK-------------LMRGAEEMFRRFPV-VSEARMVAKDQEYKGVFLK 355 Query: 390 KGSMVVIPTYALHH-DPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFAL 448 +G M+++PT ALH D EP + FS++ S ++ FG GP C GM A Sbjct: 356 RGDMILLPT-ALHGLDDAANPEPWKL---DFSRRSIS-----HSTFGGGPHRCAGMHLAR 406 Query: 449 MNMKLAL---IRVLQNFSFKPCKETQIPL 474 M + + L ++ + FSF KE + P+ Sbjct: 407 MEVIVTLEEWLKRIPEFSF---KEGETPI 432 >3EJB-B nrPDB Length = 404 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 46/171 (26%), Positives = 77/171 (45%), Gaps = 26/171 (15%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 L++ E A+ I+ AG+ETT +++S ++ L HP+ KL++ D + Sbjct: 219 LTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLI----------- 267 Query: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 V E LR R +D++I GV I +G V + A + DP +T Sbjct: 268 -------GTAVEECLRYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFT 320 Query: 410 EPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQ 460 P+ F R S +P++ FG G C+G A + ++A+ +LQ Sbjct: 321 NPDVFDITR------SPNPHL--SFGHGHHVCLGSSLARLEAQIAINTLLQ 363 >4JBT-A nrPDB Length = 410 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 107/443 (24%), Positives = 167/443 (37%), Gaps = 99/443 (22%) Query: 28 RTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYG--KMW--GTYEGQLPVLA 83 R G R+ + G L + G+ L+ RQ L DT K +W GT Q P++ Sbjct: 27 RAAGPLTRIDLLGVPALAVTGHTLA-RQLL--TDTRLVKDINAWSLWQSGTVTRQWPLIG 83 Query: 84 ITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLK 143 + D D S+FT GP E +R+R + T +L Sbjct: 84 MIDVD----------RSMFTVD---GP--------------EHRRLRIKTTQALTRRRLD 116 Query: 144 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS--MDVITGTSFGVNIDSLNNPQD 201 + P I +Y L+ +L R G V LK +F AY M VI+ GV + Q+ Sbjct: 117 ALKPTIERYVAELLDDLERAGADGAVVDLKSVF-AYPLPMRVISAL-MGVP----SEDQE 170 Query: 202 PFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRL 261 + K F F LTP E L V D ++ + R K + Sbjct: 171 QLLTWYKAF---------------FSILTPQDERLRVI----DEMHGYFTEMVRRKTAEP 211 Query: 262 NDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL 321 D L + T+ L++ E+ + AG+ETT S++ + L Sbjct: 212 GDDLTSALIY-----------ATDGETPLTEEEVIGNLQALVAAGHETTVSLILTAVRAL 260 Query: 322 ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL-FPVAIRLERTCKKD 380 +HP+ Q +L + D + E + ETLR PV L R +D Sbjct: 261 LSHPE-QLRLVR--------------DGEIGWE---TAIEETLRWDGPVIHLLMRFATED 302 Query: 381 VEINGVFIPKGSMVVIPTYALHHD-PKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPR 439 +++ IP+G VV+ A+ D + + ++F R + + + FG GP Sbjct: 303 IDLGDAVIPRGEGVVMSYRAIGRDITVHGADADDFDITRATAAR-------HISFGHGPH 355 Query: 440 NCIGMRFALMNMKLALIRVLQNF 462 C G A + +AL + F Sbjct: 356 ICPGAALARLEAAIALPALFTRF 378 >5YSW-A nrPDB Length = 441 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/194 (28%), Positives = 89/194 (45%), Gaps = 34/194 (17%) Query: 289 ALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYD 348 AL+D EL + + + AGY+TT+S+L ++ L P L+ + P++ D Sbjct: 261 ALTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDD-----PSR---IAD 312 Query: 349 AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 AV ++ VVN + F K+D+E G IP GS VV+ A + D ++W Sbjct: 313 AVEELLRYLSVVNPGIFRF---------AKEDLEFAGEHIPAGSTVVVSVVATNRDARHW 363 Query: 409 TEP--EEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLA---LIRVLQNFS 463 +P + RP P++ FG G C+G + A M M+ L+R L N Sbjct: 364 PDPDLDLTRPR---------GPHLA--FGHGVHQCLGQQLARMEMQAGYAELLRRLPNVR 412 Query: 464 FKPCKETQIPLKLD 477 E ++PL+ D Sbjct: 413 LAVPPE-EVPLRND 425 >3SN5-A nrPDB Length = 491 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 45/198 (22%), Positives = 86/198 (43%), Gaps = 25/198 (12%) Query: 292 DLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP------ 345 DLE A ++ ++A T ++L+++ +P+ + +E+ L N Sbjct: 255 DLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGN 314 Query: 346 ----TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKD----VEINGVFIPKGSMVVIP 397 + + + LD ++ E+LRL ++ + RT K+D +E I K ++ + Sbjct: 315 PICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALY 373 Query: 398 TYALHHDPKYWTEPEEFRPERFSKKKDSID----------PYIYTPFGTGPRNCIGMRFA 447 +H DP+ + +P F+ +R+ + Y Y PFG+G C G FA Sbjct: 374 PQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA 433 Query: 448 LMNMKLALIRVLQNFSFK 465 + +K LI +L F + Sbjct: 434 IHEIKQFLILMLSYFELE 451 >2WIO-A nrPDB Length = 431 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 46/176 (26%), Positives = 71/176 (40%), Gaps = 24/176 (13%) Query: 288 KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTY 347 +AL D E A S + AG+ TT+ +L + L HP ++ P + P Sbjct: 244 RALDDEEAANFSTALLLAGHITTTVLLGNIVRTLDEHPAHWDAAAED-----PGRIP--- 295 Query: 348 DAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKY 407 +V E LR P +++RT K E+ GV IP MV + + D Sbjct: 296 ----------AIVEEVLRYRPPFPQMQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDA 345 Query: 408 WTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 +P+ F P R S + FG G C+G A + ++AL ++ F Sbjct: 346 HDDPDRFDPSRKSGGAAQLS------FGHGVHFCLGAPLARLENRVALEEIIARFG 395 >6A7I-A nrPDB Length = 411 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 51/182 (28%), Positives = 78/182 (42%), Gaps = 30/182 (16%) Query: 284 TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQK-LQKEIDAVLPNK 342 +E+ L+D E+ + I AG+ETT S++ + L THP+ ++K L EI Sbjct: 219 SENGDHLTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHPEQRKKVLNGEIG------ 272 Query: 343 APPTYDAVVQMEYLDMVVNETLRL-FPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYAL 401 D V+ ETLR P + L R +D+E+ +PKG ++I AL Sbjct: 273 -------------WDGVIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGAL 319 Query: 402 HHD-PKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQ 460 D +Y EF R P + FG GP C G + + +AL + + Sbjct: 320 GRDEEQYGPTAGEFDATRT--------PNRHIAFGHGPHVCPGAALSRLEAGIALPALYE 371 Query: 461 NF 462 F Sbjct: 372 RF 373 >5XJN-A nrPDB Length = 455 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 45/171 (26%), Positives = 75/171 (43%), Gaps = 25/171 (14%) Query: 288 KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTY 347 + ++D E+A+ +FAG+ETT++++S L HP+ Q A+L N Sbjct: 275 QEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQ-------AILENP----- 322 Query: 348 DAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKY 407 + + V+E LR + R KD EI GV I +G V++ + + D Sbjct: 323 ------KLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEAR 376 Query: 408 WTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRV 458 + EEF R + ++ + FG G C+G A + K+ L V Sbjct: 377 FENGEEFDISRANARE-------HLSFGFGIHYCLGNMLAKLQAKICLEEV 420 >3TKT-A nrPDB Length = 450 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 43/166 (25%), Positives = 73/166 (43%), Gaps = 26/166 (15%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 +SD + A II AG++TTS+ + LA PD+ +++ + + +LP Sbjct: 274 MSDRDTAGYYIITASAGHDTTSASSAGAALALARDPDLFARVKADRN-LLPG-------- 324 Query: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 +V E +R RT D E+ G I G +++ A +HDP + Sbjct: 325 ---------IVEEAIRWTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFP 375 Query: 410 EPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL 455 EP +F P R + + + FG G C+G+ A + M++ L Sbjct: 376 EPRKFDPTRPANR--------HLAFGAGSHQCLGLHLARLEMRVLL 413 >5M0P-A nrPDB Length = 428 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 41/166 (24%), Positives = 67/166 (40%), Gaps = 25/166 (15%) Query: 314 LSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRL 373 +SF L+ + +P ++K++ E D Y E R +P L Sbjct: 260 VSFGLHAMNENPITREKIKSEPD------------------YAYKFAQEVRRYYPFVPFL 301 Query: 374 ERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTP 433 K D++ GV IP G + + Y HD W +P EFRPERF S P+ P Sbjct: 302 PGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFETWDGS--PFDLIP 359 Query: 434 FGTGP----RNCIGMRFALMNMKLALIRVLQNFSFK-PCKETQIPL 474 G G C G ++ M+ + + ++ P ++ ++ L Sbjct: 360 QGGGDYWTNHRCAGEWITVIIMEETMKYFAEKITYDVPEQDLEVDL 405 >4MM0-A nrPDB Length = 399 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 34/193 (17%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 L+D ++ + S+I + AGYE S+ L ++ L PD +L+++ +LP+ Sbjct: 221 LTDHDVRSLSLILLLAGYEPASNQLGSSVLTLLRFPDRLAELRRD-PGLLPS-------- 271 Query: 350 VVQMEYLDMVVNETLRLFPVAI-RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 V E +R P L R +DV I IP S V+ T A + DP+ + Sbjct: 272 ---------AVEELMRYAPAGDGALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRF 322 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK 468 +P R +R + +T G G C+G A + +++A+ +L+ F Sbjct: 323 DDPTGLRLDRPDNQ--------HTALGHGIHFCLGAALARVELQVAIGALLRRFP----- 369 Query: 469 ETQIPLKLDTQGL 481 ++ L D GL Sbjct: 370 --RLALATDESGL 380 >3TYW-A nrPDB Length = 417 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 40/162 (24%), Positives = 72/162 (44%), Gaps = 27/162 (16%) Query: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360 I I AG ETT+S+++ + L P++ +L+K+ D + V Sbjct: 245 ITINAGRETTTSMIALSTLLLLDRPELPAELRKDPD------------------LMPAAV 286 Query: 361 NETLRLFPVAIRLE-RTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF 419 +E LR+ VA + R +D+E++G +P V+ +HDP+ + +PE R Sbjct: 287 DELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRT 346 Query: 420 SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN 461 + FG G C+G A + +++AL +L+ Sbjct: 347 DNH--------HVAFGYGVHQCVGQHLARLELEVALETLLRR 380 >5GWE-A nrPDB Length = 405 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 45/171 (26%), Positives = 75/171 (43%), Gaps = 25/171 (14%) Query: 288 KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTY 347 + ++D E+A+ +FAG+ETT++++S L HP+ Q A+L N Sbjct: 225 QEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQ-------AILENP----- 272 Query: 348 DAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKY 407 + + V+E LR + R KD EI GV I +G V++ + + D Sbjct: 273 ------KLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEAR 326 Query: 408 WTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRV 458 + EEF R + ++ + FG G C+G A + K+ L V Sbjct: 327 FENGEEFDISRANARE-------HLSFGFGIHYCLGNMLAKLQAKICLEEV 370 >1UE8-A nrPDB Length = 367 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 56/236 (23%), Positives = 102/236 (43%), Gaps = 49/236 (20%) Query: 269 LDFLQLMIDSQNSKETE------SHKALSDLELAAQSIIFIFAGYETTSSVLS-----FT 317 + F + +DS+ KE ++ LS+LE I+ + AG ETT++++ FT Sbjct: 168 ISFSKKELDSRKGKEIVDLTGKIANSNLSELEKEGYFILLMIAGNETTTNLIGNAIEDFT 227 Query: 318 LYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTC 377 LY ++D V + L V E LR P +R R Sbjct: 228 LYN-------------------------SWDYVREKGAL-KAVEEALRFSPPVMRTIRVT 261 Query: 378 KKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTG 437 K+ V+I I +G +V + + + D + + +P+ F P+R P + FG+G Sbjct: 262 KEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDR--------TPNPHLSFGSG 313 Query: 438 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVD 493 C+G A + ++AL + F K + + K+D + +L + +V++V+ Sbjct: 314 IHLCLGAPLARLEARIALEEFAKKFRVKEIVKKE---KIDNE-VLNGYRKLVVRVE 365 >6F0B-A nrPDB Length = 395 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 48/182 (26%), Positives = 78/182 (42%), Gaps = 31/182 (17%) Query: 300 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMV 359 ++ I GY+TT+S +S +L A P+ + + P + P ++ Sbjct: 228 LMLIVGGYDTTASTISLSLVSYALQPEKFSVVHEH-----PERIP-------------LL 269 Query: 360 VNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418 V E LR V+ + L R +DVE+ GV + G MVV + D + P+E +R Sbjct: 270 VEELLRYHTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR 329 Query: 419 FSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL---IRVLQNFSFKPCKETQIPLK 475 S P++ FG GP C+G A + ++ A+ IR L C +P + Sbjct: 330 PSV------PHVG--FGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLA-CALEDLPFR 380 Query: 476 LD 477 D Sbjct: 381 HD 382 >3MGX-A nrPDB Length = 415 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 44/158 (27%), Positives = 66/158 (41%), Gaps = 27/158 (17%) Query: 302 FIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVN 361 + G ETT ++ ++ LAT P + L+ +D VV Sbjct: 251 VLIGGNETTRHAITGAVHALATVPGLLTALRD------------------GSADVDTVVE 292 Query: 362 ETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421 E LR A+ + R DV ING +P G+ VV A + DP + +P+ F P R Sbjct: 293 EVLRWTSPAMHVLRVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPDTFLPGR--- 349 Query: 422 KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVL 459 P + FG G +C+G A + + + L RVL Sbjct: 350 -----KPNRHITFGHGMHHCLGSALARIELSVVL-RVL 381 >5FOI-A nrPDB Length = 408 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 36/162 (22%), Positives = 72/162 (44%), Gaps = 26/162 (16%) Query: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353 EL +++ + AG+ET+++ ++ ++ L HP+ +L+++ + ++PN Sbjct: 236 ELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELREQPE-LMPN------------ 282 Query: 354 EYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413 V+E LR +A L R D+ + I G ++I + +HD + Sbjct: 283 -----AVDELLRYHSIADGLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEAT 337 Query: 414 FRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL 455 F R ++ + FG GP C+G A + M++ L Sbjct: 338 FDIHRPARH--------HVAFGYGPHQCLGQNLARLEMEVTL 371 >6HQG-A nrPDB Length = 425 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 43/178 (24%), Positives = 77/178 (43%), Gaps = 25/178 (14%) Query: 285 ESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAP 344 ES K + +E I+ I G +TT + +S ++ L +PD +KL +E ++P Sbjct: 242 ESTKNMDRMEYLGNLILLIVGGNDTTRNTISGSVLALHQNPDQDRKL-RENPGLIP---- 296 Query: 345 PTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHD 404 +V+ET+R + R K+D E+ G I +G V + + + D Sbjct: 297 -------------AMVSETIRWQTPLAYMRRRAKRDFELGGKTIREGDKVAMWYVSGNRD 343 Query: 405 PKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 + P ++ ER ++ + FG G C+G R A + +K+ +L F Sbjct: 344 EEVIDRPNDYWIERPRVRQ-------HLSFGFGVHRCVGNRLAELQLKIIWEEILARF 394 >3WVS-A nrPDB Length = 401 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 71/337 (21%), Positives = 140/337 (41%), Gaps = 64/337 (18%) Query: 128 RIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGT 187 R+R L+S FT +++E+ P + L+ ++ KG+P D+ Y++ + T Sbjct: 100 RLRRLISKAFTIRRVEELRPKVHDLAHRLIDDM---LAKGEPA---DLVADYALPIPTT- 152 Query: 188 SFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTIN 247 V + L P E +KF ++ D + + L P E V + + Sbjct: 153 ---VICELLGVP----FEDREKFGRW--TDAILSTSTLNP------EEGRVKRM--ELVG 195 Query: 248 FLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGY 307 ++ + ++++ D D + MI++++ ++ L++ EL I + AG+ Sbjct: 196 YIGGIIA-ARRAQPAD------DLISGMIEARDVQDK-----LTEQELLDHCIGLLIAGH 243 Query: 308 ETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF 367 ETT+S + +Y L P ++L + E + V E R Sbjct: 244 ETTASQIPSFVYALLDQPQHWKRLLDD------------------PELIPSAVEELFRFV 285 Query: 368 PVAI--RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDS 425 P+ R ++D+E+ G + G V++ A + D + +PEE + +R S Sbjct: 286 PLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDRPSNH--- 342 Query: 426 IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 + FG G +C+G A + ++ AL +L+ Sbjct: 343 -----HIGFGHGIHHCLGAPLARLELQEALRALLERL 374 >2Y5N-A nrPDB Length = 417 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 68/340 (20%), Positives = 133/340 (39%), Gaps = 64/340 (18%) Query: 125 EWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVI 184 E R+R L+ FT+ + + + P + LV + A G+P L +F + Sbjct: 110 EHSRLRRLVVKAFTARRAESLRPRAREIAHELVDQM---AATGQPADLVAMFARQLPVRV 166 Query: 185 TGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKD 244 GV + D F + FL T A + + Sbjct: 167 ICELLGVP----SADHDRFTRWSGAFLS-----------------TAEVTAEEMQEAAEQ 205 Query: 245 TINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF 304 ++ ++R +K +D + ++ +++ +++ S + L DL +I + Sbjct: 206 AYAYMGDLIDRRRKEPTDD-------LVSALVQARDQQDSLSEQELLDL-----AIGLLV 253 Query: 305 AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETL 364 AGYE+T++ ++ +Y L T P+++++L + + E + V E Sbjct: 254 AGYESTTTQIADFVYLLMTRPELRRQL------------------LDRPELIPSAVEELT 295 Query: 365 RLFPVAI--RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422 R P+ + R +DV + GV I G V+ T A + D + + + +R Sbjct: 296 RWVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDR---- 351 Query: 423 KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 P + FG G +C+G A + +++AL +LQ Sbjct: 352 ----TPNQHLGFGHGVHHCLGAPLARVELQVALEVLLQRL 387 >4TRI-A nrPDB Length = 407 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 46/207 (22%), Positives = 87/207 (42%), Gaps = 32/207 (15%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQ 329 D ++++S E E + +SD E+ ++++ + G ETT LS +L H D Sbjct: 203 DLFSVLVNS----EVEGQR-MSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWD 257 Query: 330 KLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIP 389 L ++D +LP + E LR + RT D +G + Sbjct: 258 ALVADVD-LLPG-----------------AIEEMLRWTSPVKNMCRTLTADTVFHGTELR 299 Query: 390 KGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALM 449 G +++ + + D + +P+ FR +R +P + FG G C+G + A + Sbjct: 300 AGEKIMLMFESANFDESVFGDPDNFRIDR--------NPNSHVAFGFGTHFCLGNQLARL 351 Query: 450 NMKLALIRVLQNF-SFKPCKETQIPLK 475 ++L RVL+ + + +PL+ Sbjct: 352 ELRLMTERVLRRLPDLRLADDAPVPLR 378 >6GK6-A nrPDB Length = 411 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 49/208 (23%), Positives = 87/208 (41%), Gaps = 35/208 (16%) Query: 283 ETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNK 342 E + HK LS EL++ + + AG+ETT +++ + L +HP +++L ++ V Sbjct: 222 EEQEHK-LSPAELSSMVFLLLVAGHETTVHLIASGMLLLLSHPAERRRLDEDPGLV---- 276 Query: 343 APPTYDAVVQMEYLDMVVNETLRL-FPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYAL 401 V E LR P + R +D+E+ G +P G V A Sbjct: 277 --------------GSAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAA 322 Query: 402 HHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN 461 + DP+++ +P+ F R P + FG G C+G A + +A +L+ Sbjct: 323 NRDPQHFPDPDRFDIGR--------SPNRHIGFGGGIHFCLGAMLARIEAAIAFSTLLRR 374 Query: 462 FSFKPCKETQIPLKLDTQGLLQPEKPIV 489 +I L T+ ++ E P + Sbjct: 375 LP-------RIELATSTRDIVWSEWPTI 395 >5LIV-A nrPDB Length = 450 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 39/169 (23%), Positives = 77/169 (45%), Gaps = 27/169 (15%) Query: 296 AAQSIIF--IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353 A++ I+ I GYETTS +++ T++ L HPD +++++ ++LP Sbjct: 268 ASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQD-PSLLP------------- 313 Query: 354 EYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413 + E +R P + + R ++DV ++ + G++V + A ++D + PE Sbjct: 314 ----AAIEEGMRWCPSSFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEV 369 Query: 414 FRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 + +R ++ FG G C+G A M ++ L +L F Sbjct: 370 YDIDRKPLPAANV-------FGGGAHFCVGAPLARMEARVGLQALLARF 411 >3ABA-A nrPDB Length = 403 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 50/185 (27%), Positives = 74/185 (40%), Gaps = 31/185 (16%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 + D+ L + + A ++TT+ ++ L PD Q L +E +++ N Sbjct: 222 VDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDSPD-QLALLREDPSLVGN-------- 272 Query: 350 VVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 V E LR + ER +DVE+ GV I KG VV A DP + Sbjct: 273 ---------AVEELLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFV 323 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKL---ALIRVLQNFSF- 464 EPE F R P + FG G CIG + A + +++ L R L Sbjct: 324 EEPERFDITR--------RPAPHLAFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLA 375 Query: 465 KPCKE 469 KP +E Sbjct: 376 KPVEE 380 >1GWI-A nrPDB Length = 411 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 51/182 (28%), Positives = 83/182 (45%), Gaps = 25/182 (13%) Query: 282 KETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPN 341 + +E+ L+D E+ + + + AG+ETT S++ + L+THP+ Q+ L VL Sbjct: 219 QASENGDHLTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPE-QRAL------VLSG 271 Query: 342 KAPPTYDAVVQMEYLDMVVNETLRL-FPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYA 400 +A + AVV+ ETLR P + L R +DV + IP G +++ A Sbjct: 272 EA--EWSAVVE---------ETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGA 320 Query: 401 LHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQ 460 L D + +RF + S + +I FG GP C G + M +AL + Sbjct: 321 LGRDERAHGPTA----DRFDLTRTSGNRHIS--FGHGPHVCPGAALSRMEAGVALPALYA 374 Query: 461 NF 462 F Sbjct: 375 RF 376 >2XKR-A nrPDB Length = 398 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 73/335 (21%), Positives = 132/335 (39%), Gaps = 62/335 (18%) Query: 130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSF 189 R L++ FT ++K+ IA D L+ + E+G+ ++D+ M VI G Sbjct: 87 RKLVNAGFTRKRVKDKEASIAALCDTLIDAV---CERGECDFVRDLAAPLPMAVI-GDML 142 Query: 190 GVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVF--EALNVSLFPKDTIN 247 GV E FL++ S L FL+ E +++ N Sbjct: 143 GVR-----------PEQRDMFLRW--------SDDLVTFLSSHVSQEDFQITMDAFAAYN 183 Query: 248 FLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGY 307 +++ +++ D D + +++ S+ E LSD EL ++++ + G Sbjct: 184 DFTRATIAARRADPTD------DLVSVLVSSEVDGER-----LSDDELVMETLLILIGGD 232 Query: 308 ETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF 367 ETT LS +L + D LQ++ ++LP + E LR Sbjct: 233 ETTRHTLSGGTEQLLRNRDQWDLLQRD-PSLLPG-----------------AIEEMLRWT 274 Query: 368 PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID 427 + R D E +G + G +++ + + D + EPE+F +R + Sbjct: 275 APVKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQR--------N 326 Query: 428 PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 P + FG G C+G + A + + L RVL+ Sbjct: 327 PNSHLAFGFGTHFCLGNQLARLELSLMTERVLRRL 361 >3RWL-A nrPDB Length = 426 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 45/170 (26%), Positives = 70/170 (41%), Gaps = 25/170 (14%) Query: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353 E ++ I G +TT + ++ + L +PD KL KA P Sbjct: 254 EYLGNVLLLIVGGNDTTRNSMTGGVLALHKNPDQFAKL----------KANPAL------ 297 Query: 354 EYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413 ++ +V E +R + RT D E+ G I KG VV+ Y+ + D + PEE Sbjct: 298 --VETMVPEIIRWQTPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEE 355 Query: 414 FRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 F +R P + FG G C+G R A M +++ +L FS Sbjct: 356 FIIDRPR-------PRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFS 398 >5FYF-A nrPDB Length = 470 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 55/219 (25%), Positives = 101/219 (46%), Gaps = 36/219 (16%) Query: 249 LSKSVNRM---KKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSD--LELAAQSIIFI 303 +++S +R+ K++R ++ D + L+ Q++KET K L + +E + I Sbjct: 252 MARSFSRLWRDKEARRAAGEEPGFDLISLL---QSNKET---KDLINRPMEFIGNLTLLI 305 Query: 304 FAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNET 363 G +TT + +S L + P +KL KA P E + +V+E Sbjct: 306 VGGNDTTRNSMSGGLVAMNEFPREFEKL----------KAKP--------ELIPNMVSEI 347 Query: 364 LRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKK 423 +R + R K+DVE+ G I KG VV+ + + D + + P++F +R K Sbjct: 348 IRWQTPLAYMRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFIIDR----K 403 Query: 424 DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 D+ + + FG G C+G R A + +++ +L+ F Sbjct: 404 DARN---HMSFGYGVHRCMGNRLAELQLRILWEEILKRF 439 >6F88-A nrPDB Length = 400 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 39/174 (22%), Positives = 77/174 (44%), Gaps = 26/174 (14%) Query: 290 LSDLELAAQSII-FIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYD 348 + +E + Q ++ I GYETTS +++ T++ L HPD +++++ P+ P Sbjct: 213 MDTIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQD-----PSLLP---- 263 Query: 349 AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 + E +R P + R ++DV ++ + G++V + A ++D + Sbjct: 264 ---------AAIEEGMRWCPSNFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAY 314 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 PE + +R ++ FG G C+G A M ++ L +L F Sbjct: 315 PSPEVYDIDRKPLPAANV-------FGGGAHFCVGAPLARMEARVGLQALLARF 361 >6A7J-A nrPDB Length = 411 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 49/181 (27%), Positives = 78/181 (43%), Gaps = 28/181 (15%) Query: 284 TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKA 343 +E L+D E+ + I AG+ETT S++ + LA HP+ ++K VL + Sbjct: 219 SEDGDHLTDEEILNTLQLIIAAGHETTISLIVNVVEALAIHPEQRKK-------VLSGEI 271 Query: 344 PPTYDAVVQMEYLDMVVNETLRL-FPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALH 402 P + V+ ETLR P + L R +D+E+ +PKG +V+ AL Sbjct: 272 P-----------WEGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALG 320 Query: 403 HD-PKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN 461 D +Y +F R P + FG GP C G + + +AL + + Sbjct: 321 RDEEQYGPTAGDFDATRT--------PNRHIAFGHGPHVCPGAALSRLEAGIALPALYER 372 Query: 462 F 462 F Sbjct: 373 F 373 >6HQW-A nrPDB Length = 445 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 40/186 (21%), Positives = 79/186 (42%), Gaps = 31/186 (16%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQ 329 D + +MI S E+ +S E ++ I G +TT + +S ++ L PD ++ Sbjct: 254 DLISMMIHS------EAMNHMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPDQRE 307 Query: 330 KLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIP 389 L+++ +++PN V E +R + RT D E+ G I Sbjct: 308 LLERDA-SLIPN-----------------AVQECIRYVTPLAHMRRTATADTELFGNQIK 349 Query: 390 KGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALM 449 G V++ + + D + P++ +R + ++ + FG G C+G R A + Sbjct: 350 AGEKVILWYISANRDETVFENPDKLMVDRPNARR-------HLSFGHGIHRCVGARLAEL 402 Query: 450 NMKLAL 455 +++ L Sbjct: 403 QLRILL 408 >2ZBZ-A nrPDB Length = 412 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 37/163 (22%), Positives = 70/163 (42%), Gaps = 27/163 (16%) Query: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353 EL + +++ + AG+ETT+S+ S ++ L HP+ L+ + +++P Sbjct: 233 ELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRAD-RSLVPG------------ 279 Query: 354 EYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPE 412 V E LR +A I R D+E+ G I G V++ + D + +P+ Sbjct: 280 -----AVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDPD 334 Query: 413 EFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL 455 R ++ + FG G C+G A + +++ L Sbjct: 335 ALDIHRSARH--------HLAFGFGVHQCLGQNLARLELEVIL 369 >4WPZ-A nrPDB Length = 397 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 44/183 (24%), Positives = 85/183 (46%), Gaps = 30/183 (16%) Query: 284 TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKA 343 ++ L++ E+ A SI + AG+ETT++ +S L L +P+ E+D + N+ Sbjct: 211 SDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNPE-------ELDKLRDNR- 262 Query: 344 PPTYDAVVQMEYLDMVVNETLRLFPVAIR---LERTCKKDVEIN-GVFIPKGSMVVIPTY 399 E + V+E LR P+ + R +VE++ G +P G++V+ Sbjct: 263 ----------EAIPKAVDELLRFVPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVA 312 Query: 400 ALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVL 459 + DP+ + + E R + +P++ FG G +C+G + A + ++ AL +L Sbjct: 313 TANRDPEVFEDGERLNVTREN------NPHLA--FGAGIHHCLGAQLARIELQEALGAIL 364 Query: 460 QNF 462 Sbjct: 365 DRM 367 >5DQN-A nrPDB Length = 426 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 46/173 (26%), Positives = 71/173 (41%), Gaps = 27/173 (15%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 LSD E ++ AG ETT + ++ + A +PD + +KE P T Sbjct: 236 LSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNPDQWELYKKE--------RPET--- 284 Query: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 +E +R +RT +DVE+ GV I KG VV+ + + D + + Sbjct: 285 ---------AADEIVRWATPVSAFQRTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFE 335 Query: 410 EPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 +P F R S +P++ GTG CIG A M + L + N Sbjct: 336 DPHTFNILR------SPNPHVGF-GGTGAHYCIGANLARMTINLIFNAIADNM 381 >5IT1-A nrPDB Length = 399 Score = 51.2 bits (121), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 46/185 (24%), Positives = 72/185 (38%), Gaps = 31/185 (16%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 + D+ L + + A ++TT+ ++ L PD LQK+ P+ Sbjct: 222 IDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDRPDQLALLQKD----------PSL-- 269 Query: 350 VVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 + V E LR + ER +D EI GV I KG VV + DP + Sbjct: 270 ------IGNAVEELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFV 323 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS----F 464 +PE F R P + FG G CIG + A + +++ + + F Sbjct: 324 EDPERFDITR--------RPAPHLAFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLA 375 Query: 465 KPCKE 469 KP +E Sbjct: 376 KPVEE 380 >1ODO-A nrPDB Length = 408 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 80/339 (23%), Positives = 135/339 (39%), Gaps = 62/339 (18%) Query: 127 KRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDV-IT 185 +++R L++P F++ ++ M P + LV L E G+PV L+ AY + + + Sbjct: 96 RKLRRLVAPAFSARRVDAMRPAVEAMVTGLVDRLA-ELPAGEPVDLRQEL-AYPLPIAVI 153 Query: 186 GTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDT 245 G GV D +D F + L G D ++E L+ Sbjct: 154 GHLMGVPQDR----RDGF-----RALVDGVFDTTLDQAEAQANTARLYEVLD-------- 196 Query: 246 INFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFA 305 + K++ D D L+I +++ E + + LS EL ++ I A Sbjct: 197 ------QLIAAKRATPGD------DMTSLLIAARDD-EGDGDR-LSPEELRDTLLLMISA 242 Query: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR 365 GYETT +V+ ++ L T PD ++K ++ + D VV ETLR Sbjct: 243 GYETTVNVIDQAVHTLLTRPDQLALVRKG-----------------EVTWAD-VVEETLR 284 Query: 366 LFPVAIRLE-RTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKK 423 P L R D+ + +G I +G ++ A + P + + + F R K+ Sbjct: 285 HEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFDATRTVKE- 343 Query: 424 DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 + FG G C+G A M + LAL + F Sbjct: 344 -------HLAFGHGVHFCLGAPLARMEVTLALESLFGRF 375 >3B98-A nrPDB Length = 475 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 119/525 (22%), Positives = 201/525 (38%), Gaps = 116/525 (22%) Query: 24 LYGTRTHGLFKRLGIP--GPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPV 81 LYG RT +R P +P LG+ L + + KF T +K+G ++ L + Sbjct: 9 LYGRRT----RRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYI 64 Query: 82 LAITDPDVIRTVLVKECY-SVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTF--- 137 + D + CY +V ++ SL + + + KRI +++ P+ Sbjct: 65 TVLLDSN---------CYDAVLSDVASLDQTSYAQVLM--------KRIFNMILPSHNPE 107 Query: 138 TSGKLKEMF---PIIAQYGDVLVRNLR---REAEKGKPVTLKDIFG----AYSMDVITG- 186 + K EM + Q + + NLR +E G + G YS+ TG Sbjct: 108 SEKKRAEMHFQGASLTQLSNSMQNNLRLLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGY 167 Query: 187 -TSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSII---------------LFPFLT 230 T FG NN + ++F +F L P L+ +LT Sbjct: 168 LTVFGAE----NNNSAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLT 223 Query: 231 PVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKAL 290 P + P++ ++L V +++ ++ + + R LQL + N Sbjct: 224 PS----GLDRKPREQ-SWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGN---------- 268 Query: 291 SDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAV 350 A F GY L THP+ + +++EI K + Sbjct: 269 ------AGPAAFWVMGY-------------LLTHPEALRAVREEIQG---GKHLRLEERQ 306 Query: 351 VQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI---NG--VFIPKGS-MVVIPTYALHHD 404 D V+ ETLRL A+ + R +D +I NG + +G + V P + D Sbjct: 307 KNTPVFDSVLWETLRLTAAAL-ITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMD 365 Query: 405 PKYWTEPEEFRPERF-----SKKKDSID-----PYIYTPFGTGPRNCIGMRFALMNMKLA 454 P+ +PE F+ +RF ++KKD Y P+GT C G FA+ +K Sbjct: 366 PQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKEL 425 Query: 455 LIRVLQNFSFKPC-KETQIPLKLDTQ---GLLQPEKPIVLKVDSR 495 + +L F + C K +PL ++ G+LQP + ++ R Sbjct: 426 VFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIR 470 >5Y1I-A nrPDB Length = 403 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 71/369 (19%), Positives = 142/369 (38%), Gaps = 83/369 (22%) Query: 122 EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSM 181 +D E RIR +++ FT+ +++ M P I + D L+ + + G + Sbjct: 92 DDPEHGRIRRMVTLPFTARRIEAMRPAIQKITDELIDGM--------------LAGPKPV 137 Query: 182 DVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLF 241 D++ + V V + L + D FL + N ++ Sbjct: 138 DLVEALALPVP-----------VRVICEMLGVPYEDREFL------------QQNNNAMI 174 Query: 242 PKDTINFLSKS--------VNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDL 293 +DT ++ + + ++L D+ L L + +++ + ++ Sbjct: 175 YRDTAQGDAQKAAIAQAMYLKELVGTKLGDRGDDILSDLAVQVEAGEITQDDA------- 227 Query: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEID-AVLPNKAPPTYDAVVQ 352 A ++ + AG+ETT+++++ L +P+ +++ D V+ N Sbjct: 228 --AGIGMMLLGAGHETTANMIALGTLALLENPEQLAEVRDSDDPKVIVN----------- 274 Query: 353 MEYLDMVVNETLRLFPVAI-RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTE- 410 V E LR +A + R +D+EI GV I G +V P A + DP + E Sbjct: 275 ------TVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEA 328 Query: 411 PEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 470 P+ R + ++ + FG G C+G A + +++ +L+ T Sbjct: 329 PDRLDIHRANARR-------HLAFGYGVHQCLGATLARVELQIVYSTLLRRIPTLALAGT 381 Query: 471 --QIPLKLD 477 +IP K D Sbjct: 382 LDEIPFKHD 390 >2RFC-A nrPDB Length = 343 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 40/164 (24%), Positives = 70/164 (42%), Gaps = 31/164 (18%) Query: 300 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMV 359 ++ I G ETT++++ + + +PD+ ID L N++ Sbjct: 183 MLLIIGGNETTTNLIGNMIRVIDENPDI-------IDDALKNRSG--------------F 221 Query: 360 VNETLRLF-PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418 V ETLR + P+ R +D IN I KG V++ + + D ++ EP+ F+ R Sbjct: 222 VEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGR 281 Query: 419 FSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 ++ FG G C+G A + +AL +L +F Sbjct: 282 RE---------MHLAFGIGIHMCLGAPLARLEASIALNDILNHF 316 >5LIE-A nrPDB Length = 414 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 44/175 (25%), Positives = 68/175 (38%), Gaps = 26/175 (14%) Query: 289 ALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYD 348 ALSD EL + AG ETT + ++ L LA +PD Q L+ + Sbjct: 237 ALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDF------------- 283 Query: 349 AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 E L + E +R + RT + V + G I G VV+ + + DP + Sbjct: 284 -----ELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVF 338 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 +EF R P + FG G C+G A + +++ +L F Sbjct: 339 DRADEFDITR--------KPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFG 385 >3R9C-A nrPDB Length = 418 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 44/204 (21%), Positives = 76/204 (37%), Gaps = 37/204 (18%) Query: 270 DFLQLMIDSQNSKE-----------TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTL 318 D+L+ +ID + ES L++ E+ A + + AG+ETT ++++ Sbjct: 210 DYLRALIDERRRTPGEDLMSGLVAVEESGDQLTEDEIIATCNLLLIAGHETTVNLIANAA 269 Query: 319 YELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCK 378 + P L + V+ ET+R P + R Sbjct: 270 LAMLRTPGQWAALAAD------------------GSRASAVIEETMRYDPPVQLVSRYAG 311 Query: 379 KDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGP 438 D+ I +PKG +++ A H DP P+ F P+R + + FG G Sbjct: 312 DDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPDRAQIR--------HLGFGKGA 363 Query: 439 RNCIGMRFALMNMKLALIRVLQNF 462 C+G A + +AL + F Sbjct: 364 HFCLGAPLARLEATVALPALAARF 387 >1CPT-A nrPDB Length = 428 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 40/164 (24%), Positives = 69/164 (42%), Gaps = 26/164 (15%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 + D + A + AG++TTSS + L+ +P+ Q L K A++P Sbjct: 252 IDDKYINAYYVAIATAGHDTTSSSSGGAIIGLSRNPE-QLALAKSDPALIPR-------- 302 Query: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 +V+E +R RT D E+ G I +G +++ + + D + ++ Sbjct: 303 ---------LVDEAVRWTAPVKSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFS 353 Query: 410 EPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKL 453 P+EF RF P + FG G C+G A + MK+ Sbjct: 354 NPDEFDITRF--------PNRHLGFGWGAHMCLGQHLAKLEMKI 389 >5XW2-A nrPDB Length = 419 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 43/214 (20%), Positives = 93/214 (43%), Gaps = 31/214 (14%) Query: 249 LSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYE 308 + K + +++ +++ R D + +I+++ + L+D + + + + AGY Sbjct: 205 MRKMLEYLREHAAECRRRPRGDLMGKLIEAEVDG-----RRLTDNHIVNFAKMLLIAGYL 259 Query: 309 TTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP 368 TT+ ++ T+ L ++P+ +++ + +++P ++ E++R Sbjct: 260 TTTMLIGNTVLCLDSYPEQAARVRAD-RSLIPG-----------------LLEESMRFLS 301 Query: 369 VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDP 428 R +DVE+ G + MV++ A + D + + EPE F R P Sbjct: 302 PVAATYRATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFDMTR--------GP 353 Query: 429 YIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 + FG G C+G A M ++AL +L F Sbjct: 354 NPHLGFGRGIHFCLGGPLARMEGRVALDHLLDRF 387 >4Z5Q-A nrPDB Length = 423 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 42/201 (20%), Positives = 86/201 (42%), Gaps = 33/201 (16%) Query: 264 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT 323 + + R D +I+++++ H L++ EL I + G+ETT+S +S ++ L Sbjct: 227 RAEPRDDLTSALIEARDA-----HDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQ 281 Query: 324 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIR--LERTCKKDV 381 ++ +L + +A+ V E LR P A R +D+ Sbjct: 282 RRELWTRLCADPEAI------------------PAAVEELLRFVPFAANGISPRYALEDM 323 Query: 382 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNC 441 + GV + +G V++ T A++ D + +E +R + + FG G +C Sbjct: 324 TVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVVIDRADNR--------HMVFGHGAHHC 375 Query: 442 IGMRFALMNMKLALIRVLQNF 462 +G A + ++ AL +++ Sbjct: 376 LGAHLARVELQEALKALVEGM 396 >4YZR-A nrPDB Length = 405 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 45/179 (25%), Positives = 70/179 (39%), Gaps = 27/179 (15%) Query: 285 ESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAP 344 E+ LS+ EL + + + AG ETT ++L L H +KL++ Sbjct: 221 ENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQ----------- 269 Query: 345 PTYDAVVQMEYLDMVVNETLRLF-PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHH 403 Q E + V E LR PV + R +D G I +G M+ I + + Sbjct: 270 -------QPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANR 322 Query: 404 DPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 DP ++ PE R P + FG G C+G A + +A +L+ F Sbjct: 323 DPNFFENPEILNINR--------SPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRF 373 >3IVY-A nrPDB Length = 433 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 47/165 (28%), Positives = 70/165 (42%), Gaps = 29/165 (17%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 LSD E ++ AG ETT + ++ + A HPD Q +L K+ V P A Sbjct: 253 LSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEHPD-QWELYKK---VRPETA------ 302 Query: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 +E +R +RT +D E++GV I KG VV+ + + D + + Sbjct: 303 ----------ADEIVRWATPVTAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQ 352 Query: 410 EPEEFRPERFSKKKDSIDPYIYTPF-GTGPRNCIGMRFALMNMKL 453 +P F R +P + F GTG CIG A M + L Sbjct: 353 DPFTFNILR--------NPNPHVGFGGTGAHYCIGANLARMTINL 389 >3NC3-A nrPDB Length = 441 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 39/161 (24%), Positives = 69/161 (42%), Gaps = 20/161 (12%) Query: 289 ALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYD 348 ALSD ++ A + + A E L+ +Y L +P+ +++ VL +++ Sbjct: 253 ALSDKDILALILNVLLAATEPADKTLALMIYHLLNNPE-------QMNDVLADRS----- 300 Query: 349 AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 + + ETLR P + R +D + G+ I K ++V A + DP+ + Sbjct: 301 ------LVPRAIAETLRYKPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAF 354 Query: 409 TEPEEFRPER--FSKKKDSIDPYIYTPFGTGPRNCIGMRFA 447 +P+ F R K + FG+G NC+G FA Sbjct: 355 EQPDVFNIHREDLGIKSAFSGAARHLAFGSGIHNCVGTAFA 395 >2WM5-A nrPDB Length = 435 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 39/193 (20%), Positives = 79/193 (40%), Gaps = 31/193 (16%) Query: 264 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT 323 + H D +++++ E LS E+A+ I+ + AG ETT + ++ + L+ Sbjct: 238 RVNHHDDLTSSLVEAEVDGER-----LSSREIASFFILLVVAGNETTRNAITHGVLALSR 292 Query: 324 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 383 +P+ + + + D + P V E +R + + RT +D+E+ Sbjct: 293 YPEQRDRWWSDFDGLAPT-----------------AVEEIVRWASPVVYMRRTLTQDIEL 335 Query: 384 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRN-CI 442 G + G V + + + D + +P F R +P + FG G + C+ Sbjct: 336 RGTKMAAGDKVSLWYCSANRDESKFADPWTFDLAR--------NPNPHLGFGGGGAHFCL 387 Query: 443 GMRFALMNMKLAL 455 G A +++A Sbjct: 388 GANLARREIRVAF 400 >1F4U-A nrPDB Length = 368 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 42/182 (23%), Positives = 83/182 (45%), Gaps = 28/182 (15%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 LSD+E I+ + AG ETT++++S ++ + T ++ Q++++E Sbjct: 194 LSDIEKLGYIILLLIAGNETTTNLISNSVIDF-TRFNLWQRIREE--------------- 237 Query: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 YL + E LR P +R R K+ V++ I +G V + + + D + + Sbjct: 238 ---NLYLK-AIEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFH 293 Query: 410 EPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKE 469 + E+F P+R +P + FG+G C+G A + ++A+ + F + Sbjct: 294 DGEKFIPDR--------NPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFRHIEILD 345 Query: 470 TQ 471 T+ Sbjct: 346 TE 347 >5HIW-A nrPDB Length = 398 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 39/163 (23%), Positives = 65/163 (39%), Gaps = 26/163 (15%) Query: 300 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMV 359 + I YETTS +L+ L L HPD +L++ Q L Sbjct: 223 LTLILGSYETTSWMLANLLVALLAHPDAMNQLRQ------------------QPSLLPQA 264 Query: 360 VNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF 419 + E+ R A + R +++ I G + G+++ + A H+D + + PE F R Sbjct: 265 IEESTRWCSSAAGIVRFVEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHR- 323 Query: 420 SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 P FG G C+G A M ++ + +L+ F Sbjct: 324 -------RPVGMLNFGGGLHYCVGAPLARMEARVGVSLLLERF 359 >6CVC-A nrPDB Length = 433 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 67/338 (19%), Positives = 129/338 (38%), Gaps = 66/338 (19%) Query: 122 EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSM 181 +D +R+RS++S FT + + + + LV + G+ + ++ G + Sbjct: 118 DDPRHQRLRSIVSRAFTPKVVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPL 177 Query: 182 DVITGTSFGVNIDSLNNPQDPFVE---STKKFLKFGFLDPLFLSIILFPFLTPVF-EALN 237 +I D + P++ + T L FG P LT F E L Sbjct: 178 QIIC--------DMMGIPEEDHEQIFHWTNVILGFGD-----------PDLTTDFDEFLQ 218 Query: 238 VSLFPKDTINFLSKSVNRMKKSRLNDKQ-KHRLDFLQLMIDSQNSKETESHKALSDLELA 296 VS+ ++ + +D++ H D +++++ E LS E+A Sbjct: 219 VSM-----------AIGGYATALADDRRVNHHGDLTTSLVEAEVDGER-----LSSSEIA 262 Query: 297 AQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYL 356 I+ + AG ETT + +S + L+ +PD + K + D + Sbjct: 263 MFFILLVVAGNETTRNAISHGMLALSRYPDERAKWWSDFDGLAAT--------------- 307 Query: 357 DMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRP 416 V E +R + + RT +DV++ G + G V + + + D + + +P F Sbjct: 308 --AVEEIVRWASPVVYMRRTLSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDV 365 Query: 417 ERFSKKKDSIDPYIYTPFGTGPRN-CIGMRFALMNMKL 453 R +P FG G + C+G A +++ Sbjct: 366 TR--------NPNPQVGFGGGGAHFCLGANLARREIRV 395 >2X9P-A nrPDB Length = 404 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 86/399 (21%), Positives = 149/399 (37%), Gaps = 101/399 (25%) Query: 113 FMKSAISLAEDEEWKR----IRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGK 168 F+ IS A+ E +R R LL+P F++ ++ EM P + + D L+ + G Sbjct: 88 FLDLLISDADAESGRRQHAETRRLLTPLFSARRVLEMQPKVEEAADTLLDAFIAQGPPG- 146 Query: 169 PVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSII---- 224 D+ G ++ + V + + P E T LD ++ Sbjct: 147 -----DLHGELTVPF----ALTVLCEVIGVPPQRRAELTTLLAGIAKLDDREGAVRAQDD 197 Query: 225 LFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKET 284 LF ++ + E P D I SRLND + Sbjct: 198 LFGYVAGLVEHKRAEPGP-DII------------SRLNDGE------------------- 225 Query: 285 ESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAP 344 L++ +A ++ +FAG ++ +S++ + LA HPD + Sbjct: 226 -----LTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAA-------------- 266 Query: 345 PTYDAVVQMEYLDMVVNETLRLFPV--AIRLERTCKKDVEINGVFIPKGSMVVIPTYALH 402 A+ + + V E LR ++ R +D+E GV I G +V+ + Sbjct: 267 ----ALADPDVMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPN 322 Query: 403 HDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 D + +T PEEF R P + FG G +CIG A + ++ ++ Sbjct: 323 FDERAFTGPEEFDAAR--------TPNPHLTFGHGIWHCIGAPLARLELRTMFTKLF--- 371 Query: 463 SFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSG 501 T++P L+PE P V ++ ++G LSG Sbjct: 372 -------TRLP-------ELRPELP-VEQLRLKEGQLSG 395 >5H1Z-A nrPDB Length = 407 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 42/186 (22%), Positives = 73/186 (39%), Gaps = 31/186 (16%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQ 329 D + +MI S E + + L +L I+ I G +TT + +S Y L PD + Sbjct: 216 DLISMMIHSDAMAEMDQMEFLGNL------ILLIVGGNDTTRNTMSAVAYGLDLFPDQRA 269 Query: 330 KLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIP 389 KL+ + P+ P T V E +R + RT D E+ G I Sbjct: 270 KLEAD-----PSMIPNT-------------VQEIIRWQTPLAHMRRTATVDSELEGQQIK 311 Query: 390 KGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALM 449 G + + + + D + + +R + ++ + FG G C+G R A + Sbjct: 312 AGDKLALWYISANRDESVFENADRIIVDRPNARR-------HLAFGHGIHRCVGARLAEL 364 Query: 450 NMKLAL 455 + + L Sbjct: 365 QIAVLL 370 >5DE9-A nrPDB Length = 410 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/104 (32%), Positives = 50/104 (48%), Gaps = 10/104 (9%) Query: 359 VVNETLRLFPV--AIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRP 416 ++E LR P A+ L R +DVEI GV I G V + A + DP+ + +P+ Sbjct: 277 AIDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDF 336 Query: 417 ERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQ 460 ER S +P++ FG GP C G A + +L + VL Sbjct: 337 ER------SPNPHVS--FGFGPHYCPGGMLARLESELLVDAVLD 372 >2RCM-A nrPDB Length = 495 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 42/150 (28%), Positives = 64/150 (42%), Gaps = 15/150 (10%) Query: 327 VQQKLQKEIDAVL-PNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI-- 383 V +L +EI +V+ N T A+ +ME VV E LR P KKD+ I Sbjct: 317 VHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGRAKKDLVIES 376 Query: 384 -NGVF-IPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKD---------SIDPYIYT 432 + F + G M+ DPK + +EF PERF ++ S P T Sbjct: 377 HDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLLRHVLWSNGPETET 436 Query: 433 PFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 P G + C G F ++ +L +I + + + Sbjct: 437 P-TVGNKQCAGKDFVVLVARLFVIEIFRRY 465 >2WIY-A nrPDB Length = 394 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 28/88 (31%), Positives = 42/88 (47%), Gaps = 12/88 (13%) Query: 359 VVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEF---R 415 ++NE +R+ P + R +DVEI GV I GS + A + DP+ + +P+ F R Sbjct: 269 IINEMVRMDPPQLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR 328 Query: 416 PERFSKKKDSIDPYIYTPFGTGPRNCIG 443 P S+ FG GP +C G Sbjct: 329 PPAASRN---------LSFGLGPHSCAG 347 >6HQD-A nrPDB Length = 420 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 44/178 (24%), Positives = 73/178 (41%), Gaps = 27/178 (15%) Query: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360 + I G +TT S +S + +P +E D V N+A L V+ Sbjct: 255 LLIVGGNDTTRSSMSGSAMACHLYP-------QEFDKVRNNRA-----------LLASVI 296 Query: 361 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420 E +R + RT +DVE G I KG VV+ + + D + P +F +R Sbjct: 297 PEVVRWQTPIAHMRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDFIADRPR 356 Query: 421 KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS-FKPCKE-TQIPLKL 476 + + FG G C+G R A + +K+ + + +S + C E ++P L Sbjct: 357 ARH-------HLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPVRVPSNL 407 >6G71-A nrPDB Length = 405 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 52/116 (44%), Gaps = 12/116 (10%) Query: 359 VVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418 V E++R + R D E++G FIP+G+ + + + + D W++P+ F ER Sbjct: 272 VFEESIRWVAPIGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFDIER 331 Query: 419 FSKKKDSIDPYIYTPFGTGPRNCIG---MRFALMNMKL-ALIRVLQNFSFKPCKET 470 S+ + FG G C+G R + ++ L AL L+ P +E Sbjct: 332 GSEA--------HLAFGKGVHVCLGAWAARSQVADVGLPALFSRLKGLRLDPNQEA 379 >3WEC-A nrPDB Length = 419 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 49/211 (23%), Positives = 85/211 (40%), Gaps = 40/211 (18%) Query: 246 INFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKE---------TESHKALSDLELA 296 INF ++ + R + + +D+ + + S N+ E + LS E+A Sbjct: 188 INF---AIPKEVADRRSAAIEESIDYFRTLATSGNAPEGLVRRLSEVSHGGDQLSVDEIA 244 Query: 297 AQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYL 356 A ++ AG ETTS+ + L + H D +++ +A P +++ Sbjct: 245 ATCLLITVAGQETTSNTIGNMLITFSRHADQFEQV----------RANP--------QFI 286 Query: 357 DMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRP 416 + V E LR P A R +D E++G I KG V++ L + E R Sbjct: 287 ENAVAEVLRFEPPAHEAGRIALEDCEVSGANITKGDAVMV---LLASGNREAVE----RG 339 Query: 417 ERFSKKKDSIDPYIYTPFGTGPRNCIGMRFA 447 + FS + + Y G G +C+G A Sbjct: 340 DTFSVTRPDVSSLSY---GRGIHHCLGSALA 367 >3A1L-A nrPDB Length = 425 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 37/168 (22%), Positives = 66/168 (39%), Gaps = 26/168 (15%) Query: 295 LAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQME 354 + + + AG+ETT++ L+ + L H DV +L+ P P Sbjct: 244 IVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELR-----TTPESTP---------- 288 Query: 355 YLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEF 414 V E +R P + R +D+ + IP+GS VV + + DP + +P+ Sbjct: 289 ---AAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVL 345 Query: 415 RPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 R ++++ FG G C+G A ++ L +L Sbjct: 346 DVHRAAERQ--------VGFGLGIHYCLGATLARAEAEIGLRALLDGI 385 >2FR7-A nrPDB Length = 412 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 37/154 (24%), Positives = 68/154 (44%), Gaps = 26/154 (16%) Query: 302 FIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVN 361 + AG +TT + ++ +Y LA PD +L+ + P+ A ++ V+ E Sbjct: 248 LLSAGLDTTVNGIAAAVYCLARFPDEFARLRAD-----PSLARNAFEEAVRFES------ 296 Query: 362 ETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421 PV RT +DVE+ G I +G V++ + + DP+ W +P+ + R + Sbjct: 297 ------PVQTFF-RTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRYDITRKTS 349 Query: 422 KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL 455 + FG+G C+G A + ++ L Sbjct: 350 G--------HVGFGSGVHMCVGQLVARLEGEVVL 375 >5Z9I-A nrPDB Length = 398 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 25/97 (25%), Positives = 45/97 (46%), Gaps = 8/97 (8%) Query: 359 VVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418 ++ E++R + R +VE+ G IPK ++++ T A + D + + +P+ F R Sbjct: 273 LLEESMRYMSPICGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGR 332 Query: 419 FSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL 455 P + FG G C+G + A M K A+ Sbjct: 333 --------SPNAHLGFGRGIHFCLGRQLARMESKAAV 361 >4DO1-A nrPDB Length = 410 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 36/154 (23%), Positives = 67/154 (43%), Gaps = 26/154 (16%) Query: 302 FIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVN 361 + AG +TT + + +Y LA P Q+L+ + P A ++ V+ E Sbjct: 246 LLSAGLDTTVNGIGAAVYCLARFPGELQRLRSD-----PTLARNAFEEAVRFES------ 294 Query: 362 ETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421 PV RT ++VE+ G I +G V++ + + DP+ W++P+ + R + Sbjct: 295 ------PVQTFF-RTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTS 347 Query: 422 KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL 455 + FG+G C+G A + ++ L Sbjct: 348 G--------HVGFGSGVHMCVGQLVARLEGEVML 373 >6M7L-A nrPDB Length = 404 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 49/186 (26%), Positives = 73/186 (39%), Gaps = 35/186 (18%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 +SD ELA + + + E T S L+ L HP+ Q L +E Sbjct: 229 ISDEELAGLCAVVMNSSVEQTESCLAAGTLLLLEHPE-QFALLRE--------------- 272 Query: 350 VVQMEYLDMVVNETLRLFPVAIRLE-RTCKKDVEINGVFIPKGSMVVIPTYALHH-DPKY 407 + E + V E +R V L+ RT +DVEI G I KG V A + DP Sbjct: 273 --RPELGEQAVEEIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL 330 Query: 408 WTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPC 467 + F R + + FG G +C+G A M +++A ++ F P Sbjct: 331 ----DGFDITRKESR--------HVAFGHGIHHCLGAPLARMELRIAFTTLVSRF---PS 375 Query: 468 KETQIP 473 T +P Sbjct: 376 LRTAVP 381 >2IJ7-A nrPDB Length = 396 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 42/202 (20%), Positives = 80/202 (39%), Gaps = 29/202 (14%) Query: 274 LMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQK 333 LM + ++ ++ +SD A + F AG +T S L+ L L P ++ L + Sbjct: 202 LMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHE 261 Query: 334 EIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL-FPVAIRLERTCKKDVEINGVFIPKGS 392 + E + V E LR+ A L R D+++ V + KG Sbjct: 262 ------------------KPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGE 303 Query: 393 MVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMK 452 +V++ + DP+++ P S + D +P + FG G C G + + Sbjct: 304 LVLVLLEGANFDPEHFPNPG-------SIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQ 356 Query: 453 LALIRVLQNFSFKPCKETQIPL 474 + + +L+ P + +P+ Sbjct: 357 IGIEALLKKM---PGVDLAVPI 375 >1LG9-A nrPDB Length = 398 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 74/374 (19%), Positives = 133/374 (35%), Gaps = 90/374 (24%) Query: 125 EWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEK-GKPVTLKDIFGAYSMDV 183 E R+R L+P FT K++ M P I Q +V + E E+ G P L A+ D Sbjct: 95 EHTRLRRKLTPGFTLRKMQRMAPYIEQ----IVNDRLDEMERAGSPADLI----AFVADK 146 Query: 184 ITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPK 243 + G V + + P+D + +F K Sbjct: 147 VPGA---VLCELVGVPRD-----------------------------------DRDMFMK 168 Query: 244 DTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETES---------HKALSDLE 294 L S+++ +++ L DK +L MI + + E +D E Sbjct: 169 LCHGHLDASLSQKRRAALGDKFSR---YLLAMIARERKEPGEGMIGAVVAEYGDDATDEE 225 Query: 295 LAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQME 354 L + + AG + S ++ + + HP+ +IDA ++ + Sbjct: 226 LRGFCVQVMLAGDDNISGMIGLGVLAMLRHPE-------QIDAFRGDE-----------Q 267 Query: 355 YLDMVVNETLRLFPVAIR-LERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413 V+E +R V R ++D+ + G I KG V+ A + DP + + Sbjct: 268 SAQRAVDELIRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDR 327 Query: 414 FRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS----FKPCKE 469 R +P + FG G +C+G A + ++ + + F P ++ Sbjct: 328 LDVTR--------EPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQD 379 Query: 470 TQIPLKLDTQGLLQ 483 T+ L GL + Sbjct: 380 TEFRLTTPAYGLTE 393 >6GII-A nrPDB Length = 479 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 36/166 (21%), Positives = 68/166 (40%), Gaps = 25/166 (15%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 ++D L + I A +ETT + L L H V +++ + +++P A Sbjct: 293 VTDSYLHSMMQAIIVAAHETTVFATTNALKTLLEHETVWREICAD-PSLIPAAA------ 345 Query: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 E LR R ++VE+ GV +P G+ +++ + +HD ++ Sbjct: 346 -----------EECLRYNGPVAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFD 394 Query: 410 EPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL 455 +PE F R + + + FG G C+G M M++ + Sbjct: 395 DPEFFDIGRSNASE-------HLNFGYGAHQCLGRNLGRMEMQIMI 433 >1EHE-A nrPDB Length = 403 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 74/342 (21%), Positives = 119/342 (34%), Gaps = 65/342 (19%) Query: 125 EWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVI 184 E RS++ PTFT +K + P I + D L+ ++++ PV L F I Sbjct: 93 EHMHQRSMVEPTFTPEAVKNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALPVPSYI 152 Query: 185 TGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSII---LFPFLTPVFEALNVSLF 241 T GV + L ++ G S L +L + E V Sbjct: 153 IYTLLGVPFNDLE-----YLTQQNAIRTNGSSTAREASAANQELLDYLAILVEQRLVE-- 205 Query: 242 PKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSII 301 PKD I +SK K DK D +Q+ + + Sbjct: 206 PKDDI--ISKLCTEQVKPGNIDKS----DAVQI------------------------AFL 235 Query: 302 FIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVN 361 + AG T ++++ + LA HPD +L+ P+ AP V Sbjct: 236 LLVAGNATMVNMIALGVATLAQHPDQLAQLKAN-----PSLAP-------------QFVE 277 Query: 362 ETLRLFPV-AIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420 E R A+ ++RT K+DV I + ++ + + D + + P+EF R Sbjct: 278 ELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKW 337 Query: 421 KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 +D + FG G CI A + + Q F Sbjct: 338 PPQDPLG------FGFGDHRCIAEHLAKAELTTVFSTLYQKF 373 >5EX6-C nrPDB Length = 434 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 66/339 (19%), Positives = 129/339 (38%), Gaps = 66/339 (19%) Query: 125 EWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVI 184 E R+R LL+P FT K++ M P I Q ++ L +G P L ++F D + Sbjct: 131 EHTRLRRLLAPGFTHRKIRRMAPYIEQ---IVTERLDEMEREGSPADLIELFA----DEV 183 Query: 185 TGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKD 244 G V + L P+D +FL + L+ SL + Sbjct: 184 PGP---VLCELLGVPRDDRA--------------MFLQL--------CHRHLDASLSGRR 218 Query: 245 TINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF 304 ++ +R + + ++K D L M+ +++ ++D EL + + Sbjct: 219 RAA-AGEAFSRYLVTMVARERKDPGDGLIGMVVAEHG------DTVTDEELRGVCVQMML 271 Query: 305 AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETL 364 AG + S ++ + L +P+ L+ ++ A + V+E + Sbjct: 272 AGDDNISGMIGLGVLALLRNPEQIAALRGDVPAA------------------ERAVDELI 313 Query: 365 RLFPVAIR-LERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKK 423 R V RT +D + I G V+ + DP + +R + Sbjct: 314 RYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPD-----ADRLDVTR 368 Query: 424 DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 +++ P++ FG G +C+G A + +++A + + F Sbjct: 369 EAV-PHVA--FGHGVHHCLGAALARLELRIAYTALWRRF 404 >6GMF-A nrPDB Length = 397 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 65/176 (36%), Gaps = 36/176 (20%) Query: 302 FIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVN 361 + AG ETT+S++ L L HP+ Q ++ V VV Sbjct: 230 LLIAGNETTTSLIGNALVALTDHPEQLAAAQADLSLV------------------PAVVE 271 Query: 362 ETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421 E LR A + R DVEI IP S+V+ + + D + +P+ F R +K Sbjct: 272 EVLRYESPAQCIFRQTMTDVEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHRDTK 331 Query: 422 KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL----------IRVLQNFSFKPC 467 + FG CIG A + K+ L RV Q S+ P Sbjct: 332 G--------HLAFGLDIHFCIGAPLARLEAKVMLEVLLARLGDIQRVSQEVSWSPS 379 >1UED-A nrPDB Length = 406 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 76/350 (21%), Positives = 129/350 (36%), Gaps = 74/350 (21%) Query: 118 ISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIF- 176 IS + E R+R +L+P FT +++ M P I D + L EAE G L+ +F Sbjct: 97 ISTYDPPEHTRLRKMLTPEFTVRRIRRMEPAIQSLIDDRLDLL--EAE-GPSADLQGLFA 153 Query: 177 ---GAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVF 233 GA+++ + G P+D E ++ + L + Sbjct: 154 DPVGAHALCELLGI-----------PRDDQREFVRRIRRNADLSRGLKA----------- 191 Query: 234 EALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDL 293 A + + F + N L++ +++ +D L +++ ++D Sbjct: 192 RAADSAAFNRYLDNLLAR-----QRADPDDG------LLGMIVRDHGDN-------VTDE 233 Query: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353 EL I G ET + ++ F + L +P Q E+ P KA Sbjct: 234 ELKGLCTALILGGVETVAGMIGFGVLALLDNPG-----QIELLFESPEKA---------- 278 Query: 354 EYLDMVVNETLR-LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPE 412 + VVNE +R L PV R KDV I+G I G V+ + D +P+ Sbjct: 279 ---ERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPD 335 Query: 413 EFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 R + FG G C+G A +++A + + F Sbjct: 336 VLDANRAAVSD--------VGFGHGIHYCVGAALARSMLRMAYQTLWRRF 377 >4XE3-A nrPDB Length = 407 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 74/366 (20%), Positives = 145/366 (39%), Gaps = 66/366 (18%) Query: 120 LAEDE-EWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGA 178 LA+D + R+R L+ FT+ +++EM P + D L+ ++ G P L + Sbjct: 94 LAQDPPDHTRLRRLVGKAFTARRVEEMRPRVRSLVDSLLDDM---VAHGSPADLVEFLAV 150 Query: 179 YSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNV 238 + GV ++ + L F D + S L A + Sbjct: 151 PFPVAVICELLGVPLEDRD-------------LFRTFSDAMLSSTRL--------TAAEI 189 Query: 239 SLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQ 298 +D + ++ V + + + D L L L D+ + L+ E+ Sbjct: 190 QRVQQDFMVYMDGLVAQRRDAPTEDL----LGALALATDNDDH--------LTKGEIVNM 237 Query: 299 SIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDM 358 + + AG+ET+ + ++ ++ L T +K ++++ + A + Sbjct: 238 GVSLLIAGHETSVNQITNLVHLLLTE-------RKRYESLVADPA-----------LVPA 279 Query: 359 VVNETLRLFPV--AIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRP 416 V E LR P+ A R +DVE++ V + G V+ + + D + + +E Sbjct: 280 AVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHADELD- 338 Query: 417 ERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 476 F ++++ P+I FG G +CIG + + ++ AL +++ F E LK Sbjct: 339 --FHRERN---PHIA--FGHGAHHCIGAQLGRLELQEALSALVRRFPTLDLAEPVAGLKW 391 Query: 477 DTQGLL 482 QG+L Sbjct: 392 -KQGML 396 >2IAG-A nrPDB Length = 482 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 44/163 (26%), Positives = 76/163 (46%), Gaps = 27/163 (16%) Query: 356 LDMVVNETLRLFP-------VAIRLERTCKKDVEINGVFIPKGS-MVVIPTYALHHDPKY 407 LD V++E+LRL V + L E N + +G +++ P + DP+ Sbjct: 319 LDSVLSESLRLTAAPFITREVVVDLAMPMADGREFN---LRRGDRLLLFPFLSPQRDPEI 375 Query: 408 WTEPEEFRPERF-----SKKKD------SIDPYIYTPFGTGPRNCIGMRFALMNMKLALI 456 +T+PE F+ RF S+KKD + Y P+G G +C+G +A+ ++K + Sbjct: 376 YTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNY-NMPWGAGHNHCLGRSYAVNSIKQFVF 434 Query: 457 RVLQNFSFKPCK-ETQIP---LKLDTQGLLQPEKPIVLKVDSR 495 VL + + + +IP L GL+QPE + ++ R Sbjct: 435 LVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 477 >3DBM-A nrPDB Length = 473 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 33/130 (25%), Positives = 58/130 (44%), Gaps = 15/130 (11%) Query: 346 TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI---NGVF-IPKGSMVVIPTYAL 401 T +A+ QM VV E+LR+ P K + I + F + KG M+ Sbjct: 320 TLEAIEQMPLTKSVVYESLRIEPPVPPQYGKAKSNFTIESHDATFEVKKGEMLFGYQPFA 379 Query: 402 HHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGP---------RNCIGMRFALMNMK 452 DPK + PEE+ P+RF +++ Y++ + GP + C G F ++ + Sbjct: 380 TKDPKVFDRPEEYVPDRFVGDGEALLKYVW--WSNGPETESPTVENKQCAGKDFVVLITR 437 Query: 453 LALIRVLQNF 462 L +I + + + Sbjct: 438 LFVIELFRRY 447 >2QBO-A nrPDB Length = 421 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 73/175 (41%), Gaps = 32/175 (18%) Query: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360 + + G +T + LSF++ LA P+ +Q+L + + E + Sbjct: 245 LLLVVGLDTVVNFLSFSMEFLAKSPEHRQEL------------------IERPERIPAAC 286 Query: 361 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420 E LR F + + R D E +GV + KG +++P D + P FS Sbjct: 287 EELLRRFSL-VADGRILTSDYEFHGVQLKKGDQILLPQMLSGLDERENACPMHV---DFS 342 Query: 421 KKKDSIDPYIYTPFGTGPRNCIGMRFA----LMNMKLALIRVLQNFSFKPCKETQ 471 ++K S +T FG G C+G A ++ +K L R+ +FS P + Q Sbjct: 343 RQKVS-----HTTFGHGSHLCLGQHLARREIIVTLKEWLTRI-PDFSIAPGAQIQ 391 >5L1U-A nrPDB Length = 401 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/179 (21%), Positives = 69/179 (38%), Gaps = 21/179 (11%) Query: 284 TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKA 343 E ALSD ++A + GYETT + L +P + +L ++ P A Sbjct: 214 AEKDGALSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAED-----PGLA 268 Query: 344 PPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHH 403 P + ++++ N L P R D+ + I G V++ A ++ Sbjct: 269 PAAVEEILRLGVGGKGSNA---LIP------RYAHGDITVGETVIRTGDAVMLAIGAANY 319 Query: 404 DPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 D + + + F R + P + FG G R+CIG A + + R+ + Sbjct: 320 DDRAFPDGGLFDLTR-------VRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRL 371 >4C9K-A nrPDB Length = 421 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 39/168 (23%), Positives = 70/168 (41%), Gaps = 29/168 (17%) Query: 308 ETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF 367 +T + L F + L+ HP+ ++++E P K L V E R F Sbjct: 259 DTVVNFLGFMMIYLSRHPETVAEMRRE-----PLK-------------LQRGVEELFRRF 300 Query: 368 PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHH-DPKYWTEPEEFRPERFSKKKDSI 426 V + R D+E +G + +G ++++PT ALH D ++ +P S++ Sbjct: 301 AV-VSDARYVVSDMEFHGTMLKEGDLILLPT-ALHGLDDRHHDDPMTV---DLSRRD--- 352 Query: 427 DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPL 474 ++ F GP C GM A + + + L L K+ +P+ Sbjct: 353 --VTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLKDRAVPI 398 >5OMS-A nrPDB Length = 409 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 45/103 (43%), Gaps = 9/103 (8%) Query: 359 VVNETLRLF-PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPE 417 + E LR P+ R K V I GV +P G+ V++ + +HD + P ++ Sbjct: 283 AIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLSYGSANHDTGKYEAPSQYDLH 342 Query: 418 RFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQ 460 R P + FG G C G+ FA M++AL + + Sbjct: 343 R--------PPLPHLAFGAGNHACAGIYFANHVMRIALEELFE 377 >6FSH-A nrPDB Length = 398 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 64/348 (18%), Positives = 120/348 (34%), Gaps = 84/348 (24%) Query: 125 EWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVI 184 E R+R LL+P FT +++ + P I + ++ L + G P L ++F D + Sbjct: 95 EHTRLRHLLTPGFTQRRMRRLAPRIEE---IVTDRLDAMEQAGPPADLIELFA----DEV 147 Query: 185 TGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKD 244 G V + + P+D + +F K Sbjct: 148 PGA---VLCELIGVPRD-----------------------------------DRDMFMKL 169 Query: 245 TINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQ---------NSKETESHKALSDLEL 295 L S+++ +++ L DK +L MI + S E ++D EL Sbjct: 170 CHGHLDASLSQKRRAALGDKFSR---YLLAMIARERKDPGDGFIGSIVAEHGDTITDEEL 226 Query: 296 AAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEY 355 + + AG + S ++ + L HP+ L+ + + Sbjct: 227 RGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSA----------------- 269 Query: 356 LDMVVNETLRLFPVAIR-LERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEF 414 D V+E +R V RT +DV + I +G V+ + D + + Sbjct: 270 -DRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRL 328 Query: 415 RPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 R P + FG G +C+G + +++A + + F Sbjct: 329 DVTRT--------PVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRF 368 >2NZA-A nrPDB Length = 413 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 27/106 (25%), Positives = 46/106 (43%), Gaps = 10/106 (9%) Query: 359 VVNETLRLFP--VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRP 416 ++E LR ++ L R +DVE++G I G V + A + DP + +P+ Sbjct: 280 ALDELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDL 339 Query: 417 ERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 +R DP + +G G C G A M +L + +L+ Sbjct: 340 DR--------DPNPHLAYGNGHHFCTGAVLARMQTELLVDTLLERL 377 >3OO3-A nrPDB Length = 384 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 55/252 (21%), Positives = 92/252 (36%), Gaps = 57/252 (22%) Query: 231 PVFEALNVSLFPKDTINFLSKSVNRMKKSRL-------------------NDKQKHRLDF 271 P + A P+D LS+ + ++SRL + K++ D Sbjct: 139 PAYIACEFLGVPRDDQAELSRMIRESRESRLPRQRTLSGLGIVNYTKRLTSGKRRDPGDG 198 Query: 272 LQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKL 331 + +I ++ E +SD ELA + + E ++ L+ + L THPD Q L Sbjct: 199 MIGVIVREHGAE------ISDEELAGLAEGNLIMAAEQMAAQLAVAVLLLVTHPD-QMAL 251 Query: 332 QKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEINGVFIPK 390 +E + E +D E LR V R DV + G I Sbjct: 252 LRE-----------------KPELIDSATEEVLRHASIVEAPAPRVALADVRMAGRDIHA 294 Query: 391 GSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMN 450 G ++ A + P +RF ++ + FG G +CIG A + Sbjct: 295 GDVLTCSMLATNRAPG----------DRFDITREKA---THMAFGHGIHHCIGAPLARLQ 341 Query: 451 MKLALIRVLQNF 462 +++AL V+ F Sbjct: 342 LRVALPAVVGRF 353 >6G5O-A nrPDB Length = 399 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 33/176 (18%), Positives = 69/176 (39%), Gaps = 26/176 (14%) Query: 288 KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTY 347 + L+ E+ ++ G +T + ++ ++ LA HP+ ++L+KE Sbjct: 203 RKLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKE------------- 249 Query: 348 DAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKY 407 E V E +R F ++ R +D + + S + + + + D Sbjct: 250 -----PEITGRAVEEMIRYFSPLTQMGRVVTEDTHVCEHAVKADSRISLCWASANRDAAV 304 Query: 408 WTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 + P E +R ++P++ FG NC+G A +K+ L + Q + Sbjct: 305 FENPNEIVLDR------KVNPHV--GFGFSHHNCLGATHARQILKILLQTLAQKVA 352 >2UUQ-A nrPDB Length = 414 Score = 36.6 bits (83), Expect = 0.028, Method: Compositional matrix adjust. Identities = 43/181 (23%), Positives = 71/181 (39%), Gaps = 27/181 (14%) Query: 293 LELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQ 352 L + A + + G +T + +L ++ L PD Q++L + +P+ Sbjct: 238 LSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPD-QRRLLLDDPEGIPD----------- 285 Query: 353 MEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPK-YWTEP 411 V E LRL L RT +DV I IP G V++ + + D + Y + Sbjct: 286 ------AVEELLRLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDA 339 Query: 412 EEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 471 E R + I T F G +C+G A M ++AL +L E++ Sbjct: 340 AELDVTRCPRN-------ILT-FSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESR 391 Query: 472 I 472 I Sbjct: 392 I 392 >3J8B-C nrPDB Length = 547 Score = 35.0 bits (79), Expect = 0.081, Method: Compositional matrix adjust. Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 7/115 (6%) Query: 78 QLPVLAITDPDVIRTVLVKECYS---VFTNRRSLGPVGFMKSAISLAEDE----EWKRIR 130 ++P +A + D R ++ K+ + V + LGP M+ + A +WK Sbjct: 369 EIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCH 428 Query: 131 SLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVIT 185 S + +GK+ ++FP + +LVR ++ E+ + T ++ + SM+ ++ Sbjct: 429 SFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLS 483 >4TX3-A nrPDB Length = 404 Score = 35.0 bits (79), Expect = 0.085, Method: Compositional matrix adjust. Identities = 61/339 (17%), Positives = 117/339 (34%), Gaps = 66/339 (19%) Query: 125 EWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVI 184 E R+R LL+P FT +++ + P I + ++ L + G P L ++F D + Sbjct: 101 EHTRLRHLLTPGFTQRRMRRLAPRIEE---IVTDRLDAMEQAGPPADLIELFA----DEV 153 Query: 185 TGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKD 244 G I + Q F++ + L L+ A F + Sbjct: 154 PGAVLCELIGVPRDDQAMFLQLCHRHLDAS--------------LSARKRAAAGEAFAR- 198 Query: 245 TINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF 304 +L + R +K + F+ ++ E ++D EL + + Sbjct: 199 ---YLVAMMARERKDPGDG-------FIGSIV-------AEHGDTITDEELRGVCVQLML 241 Query: 305 AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETL 364 AG + S ++ + L HP+ L+ + + D V+E + Sbjct: 242 AGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSA------------------DRAVDELI 283 Query: 365 RLFPVAIR-LERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKK 423 R V RT +DV + I +G V+ + D + + R Sbjct: 284 RYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRT---- 339 Query: 424 DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 P + FG G +C+G + +++A + + F Sbjct: 340 ----PVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRF 374 >5A5T-C nrPDB Length = 843 Score = 34.7 bits (78), Expect = 0.094, Method: Compositional matrix adjust. Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 7/115 (6%) Query: 78 QLPVLAITDPDVIRTVLVKECYS---VFTNRRSLGPVGFMKSAISLAEDE----EWKRIR 130 ++P +A + D R ++ K+ + V + LGP M+ + A +WK Sbjct: 624 EIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCH 683 Query: 131 SLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVIT 185 S + +GK+ ++FP + +LVR ++ E+ + T ++ + SM+ ++ Sbjct: 684 SFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLS 738 >6BLD-A nrPDB Length = 419 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 31/130 (23%), Positives = 46/130 (35%), Gaps = 22/130 (16%) Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 L+D ++AA ++ AG +TT +S L L P + L + D Sbjct: 245 LADADVAAFFVLLAVAGNDTTRQTISHGLKALTDFPSQKAWLLADFDT------------ 292 Query: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 + V E +R + RT D E+ G I G VV + + W Sbjct: 293 -----RIGTAVEELVRWATPVMTFRRTAAADFELGGQLIRAGEKVV-----MFYASGNWD 342 Query: 410 EPEEFRPERF 419 E PER Sbjct: 343 EDAFCHPERL 352 >5EX8-A nrPDB Length = 424 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 38/179 (21%), Positives = 68/179 (37%), Gaps = 28/179 (15%) Query: 285 ESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAP 344 E+ A++D EL + + A + + +L+ + + P Q L +E +P Sbjct: 245 ENGDAITDAELTGVAAFVMGAAADQVARLLAAGAWLMVEQP-AQFALLREKPETVP---- 299 Query: 345 PTYDAVVQMEYLDMVVNETLRLFPVAIRLE-RTCKKDVEINGVFIPKGSMVVIPTYALHH 403 E+LD ET+R + R +DV I + G V A + Sbjct: 300 ---------EWLD----ETMRYLTTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANR 346 Query: 404 DPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 P Y + +EF R + + FG G +C+G A + K+++ + F Sbjct: 347 -PNYPSAEDEFDITREKAE--------HLAFGHGIHHCLGRAMAELMFKVSIPALAHRF 396 >6ERI-Az nrPDB Length = 191 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 14/33 (42%), Positives = 21/33 (63%), Gaps = 3/33 (9%) Query: 135 PTFTSGKLKEMFPII---AQYGDVLVRNLRREA 164 P TS + KE+ ++ A+ G V VRN+RR+A Sbjct: 111 PPLTSDRRKELAKVVSKLAEEGKVAVRNIRRDA 143 >5MLC-9 nrPDB Length = 271 Score = 30.0 bits (66), Expect = 2.8, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 22/36 (61%), Gaps = 3/36 (8%) Query: 135 PTFTSGKLKEMFPII---AQYGDVLVRNLRREAEKG 167 P TS + KE+ ++ A+ G V VRN+RR+A K Sbjct: 189 PPLTSDRRKELAKVVSKLAEEGKVAVRNIRRDALKS 224 >1IS1-A nrPDB Length = 185 Score = 28.5 bits (62), Expect = 6.7, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 23/43 (53%), Gaps = 3/43 (6%) Query: 135 PTFTSGKLKEMFPII---AQYGDVLVRNLRREAEKGKPVTLKD 174 P T + K++ I+ A+ G V VRN+RR+A LKD Sbjct: 103 PPLTEERRKDLVKIVRGEAEGGRVAVRNIRRDANNDLKALLKD 145 >2MAH-A nrPDB Length = 128 Score = 28.5 bits (62), Expect = 7.6, Method: Compositional matrix adjust. Identities = 23/83 (27%), Positives = 33/83 (39%), Gaps = 17/83 (20%) Query: 399 YALHHDPKYWTEPEEFRPERFSKKKDSID--PYIYTPFGTGPRNCIGMRFALMNMKLALI 456 YAL H PK W + F F K + I+ +Y P + + + + Sbjct: 57 YALKHVPKCWAAIQPFLCAVFKPKCEKINGEDMVYLP-----------SYEMCRITMEPC 105 Query: 457 RVLQNFSFKP----CKETQIPLK 475 R+L N +F P C ET P K Sbjct: 106 RILYNTTFFPKFLRCNETLFPTK 128 >3IEI-A nrPDB Length = 334 Score = 28.1 bits (61), Expect = 8.8, Method: Compositional matrix adjust. Identities = 22/90 (24%), Positives = 45/90 (50%), Gaps = 2/90 (2%) Query: 232 VFEALNVSLFPKDTINFLSKSVNRMKKSR-LNDKQKHRLD-FLQLMIDSQNSKETESHKA 289 + E + V + P+ + N L + N +++ +N +Q + D F Q+MI++ ++ + Sbjct: 196 IAECVLVYMTPEQSANLLKWAANSFERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGV 255 Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLY 319 + L +Q + G+ET S+V LY Sbjct: 256 ETCKSLESQKERLLSNGWETASAVDMMELY 285 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5VEU-A nrPDB 611 e-175 6DA2-A nrPDB 585 e-167 5W0C-A nrPDB 382 e-106 2NNH-A nrPDB 381 e-106 4GQS-A nrPDB 378 e-105 1N6B-A nrPDB 378 e-105 4H1N-A nrPDB 366 e-101 3E6I-A nrPDB 357 7e-99 5E0E-A nrPDB 356 2e-98 5E58-A nrPDB 353 1e-97 3IBD-A nrPDB 347 5e-96 2PG7-A nrPDB 345 4e-95 5YLW-A nrPDB 335 3e-92 3DL9-A nrPDB 327 8e-90 6DWN-A nrPDB 325 2e-89 4R20-A nrPDB 319 2e-87 2HI4-A nrPDB 319 2e-87 6C94-A nrPDB 309 2e-84 6B82-A nrPDB 307 1e-83 3QZ1-A nrPDB 306 1e-83 5VBU-A nrPDB 299 2e-81 3MDV-A nrPDB 299 2e-81 5UYS-A nrPDB 298 3e-81 3K9V-A nrPDB 297 9e-81 3JUS-A nrPDB 292 2e-79 6IQ5-A nrPDB 286 1e-77 3TBG-A nrPDB 281 4e-76 4R1Z-A nrPDB 277 6e-75 4KPA-A nrPDB 268 5e-72 3EL3-A nrPDB 263 1e-70 5OFQ-A nrPDB 260 7e-70 3N9Z-A nrPDB 258 3e-69 5VWS-A nrPDB 254 8e-68 4WMZ-A nrPDB 250 8e-67 4RM4-A nrPDB 250 9e-67 5JLC-A nrPDB 249 2e-66 5XNT-A nrPDB 247 9e-66 3S79-A nrPDB 244 6e-65 4YT3-A nrPDB 244 6e-65 3MZS-A nrPDB 243 1e-64 6AYB-A nrPDB 243 1e-64 2W0A-A nrPDB 241 4e-64 5L94-A nrPDB 241 6e-64 3EJB-B nrPDB 241 6e-64 2Y5N-A nrPDB 239 2e-63 5FSA-A nrPDB 237 7e-63 2WX2-A nrPDB 237 1e-62 5CJE-A nrPDB 235 3e-62 2VZM-A nrPDB 235 5e-62 2VE3-A nrPDB 234 8e-62 6CR2-A nrPDB 230 1e-60 3WVS-A nrPDB 229 3e-60 4GGV-A nrPDB 229 3e-60 4XE3-A nrPDB 227 1e-59 3L4D-A nrPDB 226 1e-59 4Z5P-A nrPDB 225 4e-59 5EX6-C nrPDB 223 2e-58 4YZR-A nrPDB 222 3e-58 2X2N-A nrPDB 221 4e-58 1EHE-A nrPDB 221 5e-58 2WM5-A nrPDB 221 5e-58 4JBT-A nrPDB 221 8e-58 4UBS-A nrPDB 220 2e-57 5NWS-A nrPDB 218 4e-57 3ABB-A nrPDB 217 8e-57 3R9C-A nrPDB 217 1e-56 4OQS-A nrPDB 217 1e-56 6CVC-A nrPDB 216 1e-56 1Z8P-A nrPDB 216 2e-56 5IT1-A nrPDB 215 3e-56 6GMF-A nrPDB 215 3e-56 5Y1I-A nrPDB 215 4e-56 5XW2-A nrPDB 215 4e-56 4TRI-A nrPDB 215 4e-56 2WIO-A nrPDB 214 9e-56 4OQR-A nrPDB 213 2e-55 4Z5Q-A nrPDB 212 3e-55 1LG9-A nrPDB 212 3e-55 3B98-A nrPDB 212 4e-55 5LIE-A nrPDB 211 6e-55 4MM0-A nrPDB 210 2e-54 1Q5D-A nrPDB 210 2e-54 2XKR-A nrPDB 209 2e-54 4WPZ-A nrPDB 209 3e-54 3A50-A nrPDB 208 6e-54 3ABA-A nrPDB 208 7e-54 6GK6-A nrPDB 207 8e-54 5XJN-A nrPDB 207 1e-53 5GWE-A nrPDB 207 1e-53 1UED-A nrPDB 206 2e-53 5Z9I-A nrPDB 204 6e-53 2Z36-A nrPDB 204 8e-53 2ZBZ-A nrPDB 203 1e-52 6B11-A nrPDB 201 5e-52 5FOI-A nrPDB 201 5e-52 1ODO-A nrPDB 201 6e-52 3TYW-A nrPDB 200 2e-51 6A7J-A nrPDB 200 2e-51 5YSW-A nrPDB 200 2e-51 5FYF-A nrPDB 198 5e-51 1CPT-A nrPDB 198 7e-51 6M7X-A nrPDB 197 8e-51 1GWI-A nrPDB 196 1e-50 5DQN-A nrPDB 196 2e-50 6A7I-A nrPDB 196 3e-50 1F4U-A nrPDB 195 3e-50 6F0B-A nrPDB 195 5e-50 4ZGX-A nrPDB 193 1e-49 3IVY-A nrPDB 192 4e-49 3A1L-A nrPDB 191 7e-49 6HQW-A nrPDB 191 7e-49 6M7L-A nrPDB 190 1e-48 6HQG-A nrPDB 189 3e-48 2X9P-A nrPDB 187 1e-47 3P3Z-A nrPDB 186 1e-47 3RWL-A nrPDB 185 3e-47 2RFC-A nrPDB 184 8e-47 3NC3-A nrPDB 183 1e-46 1UE8-A nrPDB 183 1e-46 3MGX-A nrPDB 181 5e-46 3SN5-A nrPDB 179 2e-45 5DE9-A nrPDB 179 3e-45 6DCD-A nrPDB 179 3e-45 5H1Z-A nrPDB 179 3e-45 3TKT-A nrPDB 177 8e-45 5L1U-A nrPDB 177 1e-44 5LIV-A nrPDB 176 2e-44 6F88-A nrPDB 175 4e-44 2FR7-A nrPDB 174 5e-44 4DO1-A nrPDB 173 1e-43 6GII-A nrPDB 169 2e-42 5HDI-A nrPDB 167 1e-41 3BUJ-A nrPDB 165 4e-41 6HQD-A nrPDB 164 6e-41 5HIW-A nrPDB 164 6e-41 3WEC-A nrPDB 164 7e-41 2WIY-A nrPDB 160 1e-39 3OFT-A nrPDB 158 7e-39 5KYO-A nrPDB 156 3e-38 2IAG-A nrPDB 152 3e-37 3NV6-A nrPDB 151 7e-37 1WIY-A nrPDB 145 3e-35 2QBO-A nrPDB 144 7e-35 2IJ7-A nrPDB 144 1e-34 6FYJ-A nrPDB 143 2e-34 5M0P-A nrPDB 134 1e-31 2ZQJ-A nrPDB 132 5e-31 5YHJ-A nrPDB 130 1e-30 6G71-A nrPDB 129 3e-30 3AWQ-A nrPDB 122 4e-28 2RCM-A nrPDB 107 8e-24 3DBM-A nrPDB 105 4e-23 Sequences not found previously or not previously below threshold: 6FSH-A nrPDB 208 4e-54 4TX3-A nrPDB 205 4e-53 2UUQ-A nrPDB 174 8e-44 4PWV-A nrPDB 169 2e-42 6BLD-A nrPDB 165 4e-41 3OO3-A nrPDB 164 7e-41 2NZA-A nrPDB 162 3e-40 5HH3-A nrPDB 162 4e-40 5EX8-A nrPDB 158 7e-39 4FB2-A nrPDB 146 2e-35 6G5O-A nrPDB 144 7e-35 5D3U-A nrPDB 137 1e-32 4C9K-A nrPDB 130 1e-30 5OMS-A nrPDB 127 8e-30 2YJN-B nrPDB 70 3e-12 4YXC-B nrPDB 32 0.65 2FA5-A nrPDB 32 0.73 5DJQ-C nrPDB 31 1.3 4M2J-A nrPDB 31 1.4 4YXB-D nrPDB 31 1.5 3EN1-A nrPDB 31 1.8 2B8N-A nrPDB 31 1.9 3RFT-A nrPDB 30 3.1 4DJD-D nrPDB 30 3.4 3RP9-A nrPDB 29 6.5 5Y77-A nrPDB 29 7.2 4M60-A nrPDB 28 9.4 >5VEU-A nrPDB Length = 480 Score = 611 bits (1574), Expect = e-175, Method: Composition-based stats. Identities = 474/476 (99%), Positives = 475/476 (99%) Query: 22 LYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPV 81 + LYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPV Sbjct: 1 MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPV 60 Query: 82 LAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGK 141 LAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGK Sbjct: 61 LAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGK 120 Query: 142 LKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQD 201 LKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQD Sbjct: 121 LKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQD 180 Query: 202 PFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRL 261 PFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRL Sbjct: 181 PFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRL 240 Query: 262 NDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL 321 NDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL Sbjct: 241 NDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL 300 Query: 322 ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDV 381 ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDV Sbjct: 301 ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDV 360 Query: 382 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNC 441 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNC Sbjct: 361 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNC 420 Query: 442 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDG 497 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDG Sbjct: 421 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDG 476 >6DA2-A nrPDB Length = 487 Score = 585 bits (1507), Expect = e-167, Method: Composition-based stats. Identities = 404/482 (83%), Positives = 442/482 (91%), Gaps = 1/482 (0%) Query: 21 LLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLP 80 + YLYGT +HGLFK+LGIPGPTPLP LGN+LSY +G FD EC+KKYGK+WG Y+GQ P Sbjct: 1 MAYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQP 60 Query: 81 VLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSG 140 VLAITDPD+I+TVLVKECYSVFTNRR GPVGFMKSAIS+AEDEEWKR+RSLLSPTFTSG Sbjct: 61 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 120 Query: 141 KLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200 KLKEM PIIAQYGDVLVRNLRREAE GKPVTLKD+FGAYSMDVIT TSFGVNIDSLNNPQ Sbjct: 121 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ 180 Query: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSR 260 DPFVE+TKK L+F FLDP FLSI +FPFL P+ E LN+ +FP++ NFL KSV RMK+SR Sbjct: 181 DPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESR 240 Query: 261 LNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYE 320 L D QKHR+DFLQLMIDSQNSKETESHKALSDLEL AQSIIFIFAGYETTSSVLSF +YE Sbjct: 241 LEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYE 300 Query: 321 LATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKD 380 LATHPDVQQKLQ+EIDAVLPNKAPPTYD V+QMEYLDMVVNETLRLFP+A+RLER CKKD Sbjct: 301 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKD 360 Query: 381 VEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK-KDSIDPYIYTPFGTGPR 439 VEING+FIPKG +V+IP+YALH DPKYWTEPE+F PERFSKK KD+IDPYIYTPFG+GPR Sbjct: 361 VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 420 Query: 440 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTL 499 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL GLLQPEKP+VLKV+SRDGT+ Sbjct: 421 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTV 480 Query: 500 SG 501 SG Sbjct: 481 SG 482 >5W0C-A nrPDB Length = 477 Score = 382 bits (980), Expect = e-106, Method: Composition-based stats. Identities = 112/455 (24%), Positives = 186/455 (40%), Gaps = 21/455 (4%) Query: 39 PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97 PGPTPLP++GN+L + + K T K YG ++ Y G P++ + + ++ L+ Sbjct: 14 PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID- 72 Query: 98 CYSVFTNRR--SLGPVGFMKSAISLAEDEEWKRIRS---LLSPTFTSGKLKEMFPIIAQY 152 F+ R L I + ++WK IR + F GK + + + + Sbjct: 73 LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 131 Query: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212 LV LR+ K P I G +VI F D + +E + +K Sbjct: 132 ARCLVEELRKT--KASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIK 189 Query: 213 FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDT--INFLSKSVNRMKKSRLNDKQKHRLD 270 P F + F + L +++ + V ++S + + +D Sbjct: 190 I-LSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFID 248 Query: 271 FLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQK 330 + ++ + + + L ++ AG ETTS+ L + L L HP+V K Sbjct: 249 CFLMKMEKEKHNQP---SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAK 305 Query: 331 LQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI-RLERTCKKDVEINGVFIP 389 +Q+EI+ V+ P M Y D VV+E R + L D++ IP Sbjct: 306 VQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIP 365 Query: 390 KGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFGTGPRNCIGMRFAL 448 KG+ ++I ++ HD K + PE F P F + + Y PF G R C+G A Sbjct: 366 KGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAG 425 Query: 449 MNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQ 483 M + L L +LQNF+ K + P LDT ++ Sbjct: 426 MELFLFLTSILQNFNLKSLVD---PKNLDTTPVVN 457 >2NNH-A nrPDB Length = 476 Score = 381 bits (979), Expect = e-106, Method: Composition-based stats. Identities = 107/443 (24%), Positives = 176/443 (39%), Gaps = 20/443 (4%) Query: 39 PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97 PGPTPLP++GN+L + + K T K YG ++ Y G P++ + ++ L+ Sbjct: 13 PGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDN 72 Query: 98 CYSVFTNRR--SLGPVGFMKSAISLAEDEEWKRIRSLLSPT---FTSGKLKEMFPIIAQY 152 F+ R + I + + WK IR T F GK + + + + Sbjct: 73 G-EEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGK-RSIEDRVQEE 130 Query: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212 LV LR+ K P I G +VI F D + ++ + + Sbjct: 131 AHCLVEELRKT--KASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFR 188 Query: 213 FGFLDPLFLSIIL-FPFLTPVFEALNVSLFPKDTI--NFLSKSVNRMKKSRLNDKQKHRL 269 L+ ++ + FP L F + + + +++ + V + S + + + Sbjct: 189 --ILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFI 246 Query: 270 DFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQ 329 D + ++ + + + L AG ETTS+ L + L L HP+V Sbjct: 247 DCFLIKMEQEKDNQK---SEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTA 303 Query: 330 KLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEINGVFI 388 K+Q+EID V+ P M Y D VV+E R V + D + I Sbjct: 304 KVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLI 363 Query: 389 PKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFGTGPRNCIGMRFA 447 PKG+ ++ ++ HD K + P F P F K + Y PF G R C G A Sbjct: 364 PKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLA 423 Query: 448 LMNMKLALIRVLQNFSFKPCKET 470 M + L L +LQNF+ K + Sbjct: 424 RMELFLFLTTILQNFNLKSVDDL 446 >4GQS-A nrPDB Length = 477 Score = 378 bits (970), Expect = e-105, Method: Composition-based stats. Identities = 112/455 (24%), Positives = 182/455 (40%), Gaps = 21/455 (4%) Query: 39 PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97 PGPTPLP++GN+L + + K T K YG ++ Y G ++ + +V++ L+ Sbjct: 14 PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID- 72 Query: 98 CYSVFTNRR--SLGPVGFMKSAISLAEDEEWKRIRS---LLSPTFTSGKLKEMFPIIAQY 152 F+ R L I + + WK IR + F GK + + + + Sbjct: 73 LGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 131 Query: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212 LV LR+ K P I G +VI F D + +E + ++ Sbjct: 132 ARCLVEELRKT--KASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIR 189 Query: 213 FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTI--NFLSKSVNRMKKSRLNDKQKHRLD 270 P FP + F + L + + + V ++S + + +D Sbjct: 190 I-VSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFID 248 Query: 271 FLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQK 330 + ++ + L + + AG ETTS+ L + L L HP+V K Sbjct: 249 CF---LIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAK 305 Query: 331 LQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEINGVFIP 389 +Q+EI+ V+ P M Y D VV+E R + L DV+ IP Sbjct: 306 VQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIP 365 Query: 390 KGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFGTGPRNCIGMRFAL 448 KG+ ++ ++ HD K + PE F P F + + Y PF G R C+G A Sbjct: 366 KGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLAR 425 Query: 449 MNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQ 483 M + L L +LQNF+ K + P LDT ++ Sbjct: 426 MELFLFLTFILQNFNLKSLID---PKDLDTTPVVN 457 >1N6B-A nrPDB Length = 473 Score = 378 bits (970), Expect = e-105, Method: Composition-based stats. Identities = 113/455 (24%), Positives = 189/455 (41%), Gaps = 24/455 (5%) Query: 39 PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97 PGPTP P++GN+L + + K T+ + YG ++ Y G P + + + ++ LV Sbjct: 13 PGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEAVKEALVD- 71 Query: 98 CYSVFTNRRSLGPVGFMKSA--ISLAEDEEWKRIRS---LLSPTFTSGKLKEMFPIIAQY 152 F R S+ + + I+ + + WK +R + F GK + + I + Sbjct: 72 LGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGK-RSIEDRIQEE 130 Query: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212 LV LR+ P I G +VI F D + +ES + ++ Sbjct: 131 ARCLVEELRKT--NASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLMESLHENVE 188 Query: 213 FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTI--NFLSKSVNRMKKSRLNDKQKHRLD 270 P FP L F ++ +L NF+ + V +K + + +D Sbjct: 189 L-LGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVNNPRDFID 247 Query: 271 FLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQK 330 + ++ +N+ E + L AG ETTS+ L ++L L HP+V + Sbjct: 248 CFLIKMEQENNLE------FTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVAAR 301 Query: 331 LQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIR-LERTCKKDVEINGVFIP 389 +Q+EI+ V+ P +M Y D V++E R + L +DV FIP Sbjct: 302 VQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRNYFIP 361 Query: 390 KGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFGTGPRNCIGMRFAL 448 KG+ ++ ++ HD K + P+ F P F + + Y PF G R C+G A Sbjct: 362 KGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGEGLAR 421 Query: 449 MNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQ 483 M + L L +LQNF + E P LD ++ Sbjct: 422 MELFLFLTSILQNFKLQSLVE---PKDLDITAVVN 453 >4H1N-A nrPDB Length = 479 Score = 366 bits (939), Expect = e-101, Method: Composition-based stats. Identities = 115/454 (25%), Positives = 190/454 (41%), Gaps = 19/454 (4%) Query: 39 PGPTPLPLLGNVLSY-RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97 PGP+PLP+LGN+L R+GL + +KYG ++ Y G PV+ + D IR LV + Sbjct: 13 PGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAIREALVDQ 72 Query: 98 CYSVFTNRRSLGPVG--FMKSAISLAEDEEWKRIRSLLSPT---FTSGKLKEMFPIIAQY 152 F+ R + V F + A E W+ +R T F GK + + I + Sbjct: 73 A-EAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGMGK-RSVEERIQEE 130 Query: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212 LV LR+ KG + +F + + ++I FG D + ++ + Sbjct: 131 ARCLVEELRKS--KGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFS 188 Query: 213 FGFLDPLFLSIILFPFLTPVFEALNVSLFPK--DTINFLSKSVNRMKKSRLNDKQKHRLD 270 + LF F + ++ + F+ +SV + + + + D Sbjct: 189 LISSFSSQVF-ELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPR---D 244 Query: 271 FLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQK 330 F+ + + +++ L + AG ETTS+ L + + +P V ++ Sbjct: 245 FIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPHVTER 304 Query: 331 LQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEINGVFIP 389 +QKEI+ V+ + PP D +M Y D V++E RL + + T KD + G IP Sbjct: 305 VQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIP 364 Query: 390 KGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY-IYTPFGTGPRNCIGMRFAL 448 K + V + HDP+Y+ P F P F ++ + PF G R C+G A Sbjct: 365 KNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGEGIAR 424 Query: 449 MNMKLALIRVLQNFSF-KPCKETQIPLKLDTQGL 481 + L +LQNFS P I L G+ Sbjct: 425 TELFLFFTTILQNFSIASPVPPEDIDLTPRESGV 458 >3E6I-A nrPDB Length = 476 Score = 357 bits (916), Expect = 7e-99, Method: Composition-based stats. Identities = 103/464 (22%), Positives = 186/464 (40%), Gaps = 18/464 (3%) Query: 39 PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97 PGP PLP++GN+ + + K T +++G ++ Y G ++ + ++ L+ Sbjct: 13 PGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD- 71 Query: 98 CYSVFTNRRSLGPVGFMKS-AISLAEDEEWKRIRSLLSPTFTSGKL--KEMFPIIAQYGD 154 F+ R L + I WK IR T + + + I + Sbjct: 72 YKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAH 131 Query: 155 VLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFG 214 L+ LR+ +G+P + G +VI F + D + + + Sbjct: 132 FLLEALRKT--QGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHL- 188 Query: 215 FLDPLFLSIILFPFLTPVFEALNVSLFPK--DTINFLSKSVNRMKKSRLNDKQKHRLDFL 272 P FP + + + ++S+ V +S + + D L Sbjct: 189 LSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCL 248 Query: 273 QLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQ 332 + ++ + + + + + + FAG ETTS+ L + L L +P++++KL Sbjct: 249 LVEMEKE---KHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLH 305 Query: 333 KEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIR-LERTCKKDVEINGVFIPKG 391 +EID V+ P +M Y+D VV+E R + L +D G IPKG Sbjct: 306 EEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKG 365 Query: 392 SMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYT-PFGTGPRNCIGMRFALMN 450 ++VV ++ +D + + +PE+F+PE F + Y PF TG R C G A M Sbjct: 366 TVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARME 425 Query: 451 MKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDS 494 + L L +LQ+F+ KP + P +D + I + Sbjct: 426 LFLLLCAILQHFNLKPLVD---PKDIDLSPIHIGFGCIPPRYKL 466 >5E0E-A nrPDB Length = 463 Score = 356 bits (912), Expect = 2e-98, Method: Composition-based stats. Identities = 102/443 (23%), Positives = 178/443 (40%), Gaps = 19/443 (4%) Query: 49 NVLSYRQG-LWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRS 107 N+L +G +KYG ++ + G PV+ + + IR LV + F+ R + Sbjct: 14 NLLQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQA-EAFSGRGT 72 Query: 108 LGPVG--FMKSAISLAEDEEWKRIRSLLSPT---FTSGKLKEMFPIIAQYGDVLVRNLRR 162 + V F + A E WK +R T F GK + + I + LV R+ Sbjct: 73 IAVVEPIFRGYGVVFANGERWKALRRFSLVTMRDFGMGK-RSVEERIQEEARCLVEEFRK 131 Query: 163 EAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLS 222 +G P+ +F + ++I FG D ++ + + + Sbjct: 132 S--QGAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVF 189 Query: 223 IILFPFLTPVFEALNVSLFPK--DTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQN 280 LF F + + + ++++ +SV + + + H DF+ + Sbjct: 190 -ELFSGFLKYFPGTHRQISRNLQEILDYIGQSVEKHRATL---DPSHPRDFIDTYLLRME 245 Query: 281 SKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLP 340 +++ H L + FAG ET+S+ L + + +P V +K+QKEID V+ Sbjct: 246 KEKSNQHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIG 305 Query: 341 NKAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEINGVFIPKGSMVVIPTY 399 + PT + +M Y + V+ E R + I + KD G +PK + V Sbjct: 306 SHRLPTLEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILS 365 Query: 400 ALHHDPKYWTEPEEFRPERFSKKKDSIDPY-IYTPFGTGPRNCIGMRFALMNMKLALIRV 458 + HDP+Y+ +P+ F P+ F ++ + PF G R C+G A + L + Sbjct: 366 SALHDPQYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTI 425 Query: 459 LQNFSF-KPCKETQIPLKLDTQG 480 LQNFS P I L G Sbjct: 426 LQNFSLSSPVAPKDIDLSPKESG 448 >5E58-A nrPDB Length = 493 Score = 353 bits (905), Expect = 1e-97, Method: Composition-based stats. Identities = 100/445 (22%), Positives = 179/445 (40%), Gaps = 21/445 (4%) Query: 49 NVLSYRQG-LWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRS 107 N+L +G +KYG ++ + G PV+ + + IR LV + F+ R + Sbjct: 42 NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQA-EAFSGRGT 100 Query: 108 LGPVG--FMKSAISLAEDEEWKRIRSLLSPT---FTSGKLKEMFPIIAQYGDVLVRNLRR 162 + + + + E WK +R T F GK + + I + LV L++ Sbjct: 101 IAVIKPVIGDYGMIFSNGERWKVLRRFSLATMRDFGMGK-RSVEDRIQEEAQCLVEELQK 159 Query: 163 EAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLS 222 +G P+ +F + ++I FG D + ++ + F + Sbjct: 160 S--QGAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYR--TFSLMSSFSSQ 215 Query: 223 II-LFPFLTPVFEALNVSLFPK--DTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQ 279 + LF F + + + ++++ +SV + + + + DF+ + Sbjct: 216 VFELFSGFMKYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPR---DFIDTYLLRM 272 Query: 280 NSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL 339 +++ H L + FAG ETTS+ L + + +P V +K+QKEID V+ Sbjct: 273 EKEKSNQHTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVI 332 Query: 340 PNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI-RLERTCKKDVEINGVFIPKGSMVVIPT 398 + PT + +M Y D V++E R +A KD G +PK + V Sbjct: 333 GSHRLPTLEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPIL 392 Query: 399 YALHHDPKYWTEPEEFRPERFSKKKDSIDPY-IYTPFGTGPRNCIGMRFALMNMKLALIR 457 + HDP+Y+ +P F P+ F ++ + PF G R C+G A + L Sbjct: 393 SSALHDPQYFEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTT 452 Query: 458 VLQNFSF-KPCKETQIPLKLDTQGL 481 +LQNFS I L G+ Sbjct: 453 ILQNFSVSSSVAPKDIDLSPKESGI 477 >3IBD-A nrPDB Length = 476 Score = 347 bits (891), Expect = 5e-96, Method: Composition-based stats. Identities = 100/459 (21%), Positives = 183/459 (39%), Gaps = 21/459 (4%) Query: 49 NVLSY-RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRS 107 N+L R+GL K +KYG ++ + G PV+ + + IR LV + F+ R Sbjct: 23 NLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKA-EAFSGRGK 81 Query: 108 LGPVG--FMKSAISLAEDEEWKRIRSLLSPT---FTSGKLKEMFPIIAQYGDVLVRNLRR 162 + V F + A WK +R T F GK + + I + L+ LR+ Sbjct: 82 IAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRK 140 Query: 163 EAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLS 222 KG + +F + + ++I FG + + + F + +F Sbjct: 141 S--KGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQ--TFSLISSVFGQ 196 Query: 223 II-LFPFLTPVFEALNVSLFPK--DTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQ 279 + LF F + ++ + ++ SV + +++ + D + + Sbjct: 197 LFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPR---DLIDTYLLHM 253 Query: 280 NSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL 339 +++ +H S L ++ FAG ETTS+ L + + +P V +++ +EI+ V+ Sbjct: 254 EKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVI 313 Query: 340 PNKAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEINGVFIPKGSMVVIPT 398 PP +M Y + V+ E R + + + + G IPK + V + Sbjct: 314 GPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLIL 373 Query: 399 YALHHDPKYWTEPEEFRPERFSKKKDSIDP-YIYTPFGTGPRNCIGMRFALMNMKLALIR 457 HDP Y+ +P+ F P+ F ++ + PF G R C+G A + L Sbjct: 374 STALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTT 433 Query: 458 VLQNFSF-KPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495 +LQNFS P I L G+ + ++ R Sbjct: 434 ILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 472 >2PG7-A nrPDB Length = 476 Score = 345 bits (884), Expect = 4e-95, Method: Composition-based stats. Identities = 105/449 (23%), Positives = 182/449 (40%), Gaps = 21/449 (4%) Query: 39 PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97 PGPTPLP +GN L + ++ + ++YG ++ + G V+ + D +R LV + Sbjct: 13 PGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQ 72 Query: 98 CYSVFTNRRSLGPVG--FMKSAISLAEDEEWKRIRSLLSPT---FTSGKLKEMFPIIAQY 152 F+ R F + + E K++R T F GK + + I + Sbjct: 73 A-EEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGK-RGIEERIQEE 130 Query: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212 L+ LR G + +VI+ FG D + + + Sbjct: 131 AGFLIDALRGTG--GANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQ 188 Query: 213 FGFLDPLFLSIILFPFLTPVFEALNVSLFP--KDTINFLSKSVNRMKKSRLNDKQKHRLD 270 F L +F + F + +F++K V +++ + + D Sbjct: 189 FTSTSTGQL-YEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPR---D 244 Query: 271 FLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQK 330 F+ + +E + L ++ G ET S+ L + L HP+V+ K Sbjct: 245 FIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPEVEAK 304 Query: 331 LQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI-RLERTCKKDVEINGVFIP 389 + +EID V+ P ++ +M Y++ V++E R V L R KKD + F+P Sbjct: 305 VHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLP 364 Query: 390 KGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY-IYTPFGTGPRNCIGMRFAL 448 KG+ V ++ DP +++ P++F P+ F +K + PF G RNC G A Sbjct: 365 KGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLAR 424 Query: 449 MNMKLALIRVLQNFSFKPCKETQIPLKLD 477 M + L V+QNF K +Q P +D Sbjct: 425 MELFLFFTTVMQNFRLK---SSQSPKDID 450 >5YLW-A nrPDB Length = 495 Score = 335 bits (859), Expect = 3e-92, Method: Composition-based stats. Identities = 111/480 (23%), Positives = 211/480 (43%), Gaps = 20/480 (4%) Query: 9 VETWLLLAVSLVLLYLYGTRTHGLFKRLGI--PGPTPLPLLGNVLSYRQGLWKFDTECYK 66 ++++ LLA L ++ T T F+R PGP P P++GN+L + + K Sbjct: 1 MDSFPLLAA---LFFIAATITFLSFRRRRNLPPGPFPYPIVGNMLQLGANPHQVFAKLSK 57 Query: 67 KYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMK-SAISLAEDE- 124 +YG + + G L + ++ P++ + +L + VF+ R V IS+ Sbjct: 58 RYGPLMSIHLGSLYTVIVSSPEMAKEILHRHG-QVFSGRTIAQAVHACDHDKISMGFLPV 116 Query: 125 --EWKRIRSLLSPT-FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSM 181 EW+ +R + F++ ++ + Q L+ ++++ ++ G+ V +++ ++ Sbjct: 117 ASEWRDMRKICKEQMFSNQSMEASQGLRRQKLQQLLDHVQKCSDSGRAVDIREAAFITTL 176 Query: 182 DVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLS--IILFPFLTPVFEALNVS 239 ++++ T F ++ + + + P F IL PF + Sbjct: 177 NLMSATLFSSQATEFDSKATMEFKEIIEGVATIVGVPNFADYFPILRPFDPQGVKRRADV 236 Query: 240 LFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQS 299 F K R++ R N + DFL++++D + E + L Sbjct: 237 FFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFK----LKTHHFTHLM 292 Query: 300 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMV 359 + G +T ++ + + + EL +PD +L+ E+ +V ++ A+ ++ YL V Sbjct: 293 LDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAMPKLPYLQAV 352 Query: 360 VNETLRLFPVAI-RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418 + E +R+ P L R + D E+NG IPKG+ ++I YA+ DP WT+PE F PER Sbjct: 353 IKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTDPETFDPER 412 Query: 419 FSKKKDSIDPYIY--TPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 476 F K Y PFG+G R C GM A + +A ++ NF +K ++ Sbjct: 413 FLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWKLEDDSTAAADH 472 >3DL9-A nrPDB Length = 479 Score = 327 bits (837), Expect = 8e-90, Method: Composition-based stats. Identities = 106/448 (23%), Positives = 186/448 (41%), Gaps = 17/448 (3%) Query: 57 LWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPV---GF 113 + + + YG+++ G + + + DV++ LV + +F +R L Sbjct: 36 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQS-EIFADRPCLPLFMKMTK 94 Query: 114 MKSAISLAEDEEWKRIRSLLSPTFTS--GKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT 171 M ++ W R L +F K I + + E KG+P Sbjct: 95 MGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAI--ETYKGRPFD 152 Query: 172 LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTP 231 K + ++ FG + +E + ++ +FL FP++ Sbjct: 153 FKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFL-YNAFPWIGI 211 Query: 232 VFEALNVSLFPKDTI--NFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKA 289 + + LF + +FLS+ + +K+ +N K + F+ +D + + + Sbjct: 212 LPFGKHQQLFRNAAVVYDFLSRLI---EKASVNRKPQLPQHFVDAYLDEMDQGKNDPSST 268 Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349 S L I AG ETT++VL + + +A +P++Q ++QKEID ++ P++D Sbjct: 269 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 328 Query: 350 VVQMEYLDMVVNETLRLFPVAI-RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 +M Y + V++E LR + + +D + G IPKG+ V+ Y++H D KYW Sbjct: 329 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 388 Query: 409 TEPEEFRPERFSKKKDSI-DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPC 467 +PE F PERF PF G R+C+G A M M L +LQ F Sbjct: 389 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP 448 Query: 468 KETQIPLKLDTQGLLQPEKPIVLKVDSR 495 E LK LQP+ P ++ + R Sbjct: 449 HELVPDLKPRLGMTLQPQ-PYLICAERR 475 >6DWN-A nrPDB Length = 491 Score = 325 bits (834), Expect = 2e-89, Method: Composition-based stats. Identities = 103/458 (22%), Positives = 177/458 (38%), Gaps = 22/458 (4%) Query: 36 LGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLV 95 PGP PL+G++L+ + + ++YG + G PV+ ++ D IR LV Sbjct: 11 KNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALV 70 Query: 96 KECYSVFTNRRSLGPVGFMKSAISLA----EDEEWKRIRSLLSPTFTSGKLKE------- 144 ++ F R L + + S++ W R L S + Sbjct: 71 RQG-DDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS 129 Query: 145 --MFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDP 202 + +++ +VL+ L+ +VI FG D + Sbjct: 130 CYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLS 189 Query: 203 FVESTKKFLK-FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRL 261 V F + G +P IL P A + +F+ K V K+ Sbjct: 190 LVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKD--LNEKFYSFMQKMVKEHYKTFE 247 Query: 262 NDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL 321 + D L + E ++ LSD ++ + AG++T ++ +S++L L Sbjct: 248 KGHIRDITDSLIEHCQEKQLDE-NANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYL 306 Query: 322 ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI-RLERTCKKD 380 +P VQ+K+Q+E+D V+ P + Y++ + ET R + + +D Sbjct: 307 VMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRD 366 Query: 381 VEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY---TPFGTG 437 + G +IPKG V + + ++HD K W P EF PERF +ID + FG G Sbjct: 367 TSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 426 Query: 438 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK 475 R CIG A + L L +LQ F ++ + Sbjct: 427 KRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMT 464 >4R20-A nrPDB Length = 486 Score = 319 bits (817), Expect = 2e-87, Method: Composition-based stats. Identities = 112/442 (25%), Positives = 197/442 (44%), Gaps = 23/442 (5%) Query: 57 LWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKS 116 T+ +YG ++G Y G L +++ ++R VL++ F R + + Sbjct: 41 PHLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGRE-FAGRPKMVTTDLLTQ 99 Query: 117 A---ISLAE-DEEWKRIRSLLSPTFTS--GKLKEMFPIIAQYGDVLVRNLRREAEKGKPV 170 I+ A+ WK R L+ +FT ++ I+ + D L L+ A +G+ Sbjct: 100 GGKDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQ--ACRGQSS 157 Query: 171 TLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTK---KFLKFGFLDPLFLSIILFP 227 L + +VI F + + ++ + + G L +F + +FP Sbjct: 158 DLSVVLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWLRIFP 217 Query: 228 FLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESH 287 + L + +D + L K + KKS + + D L ++ Q Sbjct: 218 --NKDLKRLKECVSIRDQL--LYKKLLEHKKSLTPGEPR---DLLDALLIGQQRGSG-GA 269 Query: 288 KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTY 347 +++ + + AG ETTS+ L +T+ L HP +Q+++Q E+D + PP Sbjct: 270 DDITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCL 329 Query: 348 DAVVQMEYLDMVVNETLRLFPVAI-RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPK 406 + LD V+ E +R+ PV+ + +D + G +PKG+ V++ +A+HHDPK Sbjct: 330 SDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPK 389 Query: 407 YWTEPEEFRPERFSKKKDSID-PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK 465 +W +PE+F PERF + + PFG GPR C+G A + + L + R LQ FSF Sbjct: 390 HWDQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFS 449 Query: 466 PCKETQIP-LKLDTQGLLQPEK 486 E +P L+ +LQPE+ Sbjct: 450 CPSEASLPDLQGRFGVVLQPER 471 >2HI4-A nrPDB Length = 495 Score = 319 bits (816), Expect = 2e-87, Method: Composition-based stats. Identities = 105/474 (22%), Positives = 181/474 (38%), Gaps = 25/474 (5%) Query: 21 LLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLP 80 + L G R P P PLLG+VL+ + + ++YG + G P Sbjct: 1 MAVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTP 60 Query: 81 VLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSA----ISLAEDEEWKRIRSLLSPT 136 VL ++ D IR LV++ F R L + S W R L Sbjct: 61 VLVLSRLDTIRQALVRQG-DDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNA 119 Query: 137 FTSGKLKE---------MFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGT 187 + + + +++ L+ L+ + +VI Sbjct: 120 LNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAM 179 Query: 188 SFGVNIDSLNNPQDPFVESTKKFLKFGFL-DPLFLSIILFPFLTPVFEALNVSLFPKDTI 246 FG + ++ V++T +F++ +PL IL P + F + + Sbjct: 180 CFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA--FNQRFL 237 Query: 247 NFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAG 306 FL K+V + + + D + S + ++ AG Sbjct: 238 WFLQKTVQEHYQDFDKNSVR---DITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAG 294 Query: 307 YETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL 366 ++T ++ +S++L L T P++Q+K+QKE+D V+ + P Q+ YL+ + ET R Sbjct: 295 FDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRH 354 Query: 367 FPVAI-RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDS 425 + + +D +NG +IPK V + + ++HDP+ W +P EFRPERF + Sbjct: 355 SSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGT 414 Query: 426 ----IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK 475 FG G R CIG A + L L +LQ F ++ L Sbjct: 415 AINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLT 468 >6C94-A nrPDB Length = 497 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 126/476 (26%), Positives = 219/476 (46%), Gaps = 36/476 (7%) Query: 38 IPGPTPLPLLGNVLSYRQ----GLWKFDTECYKKYGKMW-GTYEGQLPVLAITDPDVIRT 92 PGP L G+ L ++ T+ + +W G + G L I +PD + Sbjct: 24 FPGPPTHWLFGHALEIQKTGSLDKVVTWTQQFPYAHPLWVGQFIG---FLNIYEPDYAKA 80 Query: 93 VLVK------ECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMF 146 V + + Y F + ++ + + + +W + R LL+P F LK Sbjct: 81 VYSRGDPKAPDVYDFF--------LQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLKPYV 132 Query: 147 PIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVES 206 I A +++ ++A +GK + G ++D + +FG LN+ + + Sbjct: 133 AIFADSTRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVA 192 Query: 207 TKKF--LKFGFLDPLFLSIILFPFLTPV----FEALNVSLFPKDTINFLSKSVNRMKKSR 260 + L +D +LTP A + D + K+ + +K R Sbjct: 193 VSELTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAALQDEKER 252 Query: 261 LNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYE 320 + + LDFL +++D + ES LSD +L A+ F+F G++TT+S +S+ LY Sbjct: 253 EKIQNRRHLDFLDILLDVR----GESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYC 308 Query: 321 LATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKD 380 +A +P+ QQ+ ++E+ +L ++ ++ + +M YL M + E RL+P ++ R K Sbjct: 309 MALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKP 368 Query: 381 VEI-NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID-PYIYTPFGTGP 438 V +G +P GS++ + YALH + W +PE F P RFS + S PY + PF GP Sbjct: 369 VSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGP 428 Query: 439 RNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDS 494 RNCIG +FA+ MK+ L F F ++P+KL Q +L+ + I L + Sbjct: 429 RNCIGQQFAMNEMKVVTALCLLRFEFS-VDPLRLPIKLP-QLVLRSKNGIHLYLKP 482 >6B82-A nrPDB Length = 509 Score = 307 bits (785), Expect = 1e-83, Method: Composition-based stats. Identities = 109/491 (22%), Positives = 201/491 (40%), Gaps = 43/491 (8%) Query: 30 HGLFKRLGIPGPTPLPLLGNVLSYRQG--LWKFDTECYKKYGKMWGTYEGQLPVLAITDP 87 P LP++G+++S F + KKYG ++ G +L + + Sbjct: 17 FVPAGNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNH 76 Query: 88 DVIRTVLVKECYSVFTNRRSLGPVGFM---KSAISLAE-DEEWKRIRSLLSPT---FTSG 140 + +L+K+ +F R + I+ A+ WK R ++ F G Sbjct: 77 HHAKEILIKKGK-IFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEG 135 Query: 141 KLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200 + + II + + L + V L +V+ F + + Sbjct: 136 SV-SIEKIICREASSMCEVLTES--QNSAVDLGPELTRAVTNVVCALCFNSSYKRGDAEF 192 Query: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSR 260 + ++ ++ + D L + +FP+L +FP + L + ++ K Sbjct: 193 ESMLQYSQGIVDTVAKDSL---VDIFPWL---------QIFPNKDLRILRQCISIRDKLL 240 Query: 261 LNDKQKH--------RLDFLQLMIDSQNSKETESHKA----LSDLELAAQSIIFIFAGYE 308 ++H + D L ++ ++ S E + L++ + AG E Sbjct: 241 QKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVE 300 Query: 309 TTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP 368 TT++ L +++ L +P VQ+K+Q+E+D+ + + P + YL+ + E +R+ P Sbjct: 301 TTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRP 360 Query: 369 VAIRL-ERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI- 426 V+ L +D + + KG+ VVI ++LHHD K W PE F P RF ++ Sbjct: 361 VSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGL 420 Query: 427 --DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP-LKLDTQGLLQ 483 Y PFG G R C+G A M + L L +LQ F+ + +P L+ +LQ Sbjct: 421 CCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQ 480 Query: 484 PEK-PIVLKVD 493 P+K +V KV Sbjct: 481 PKKFKVVAKVR 491 >3QZ1-A nrPDB Length = 496 Score = 306 bits (784), Expect = 1e-83, Method: Composition-based stats. Identities = 113/475 (23%), Positives = 195/475 (41%), Gaps = 22/475 (4%) Query: 31 GLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVI 90 G +K + P +P ++L L +K G ++ G V+ + I Sbjct: 21 GRWKLRNLHLPPLVPGFLHLLQ--PNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTI 78 Query: 91 RTVLVKECYSVFTNRRSLGPVGFMKS---AISLAEDEE-WKRIRSLLSPTFTSGKLKEMF 146 ++++ F R + + ISL + WK + L G M Sbjct: 79 EEAMIRKWVD-FAGRPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALLLGTRSSME 137 Query: 147 PIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVES 206 P + Q +R +A G PVT++ F + +I +FG D+L + V+ Sbjct: 138 PWVDQLTQEFCERMRVQA--GAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQD 195 Query: 207 TKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQK 266 K + L + L F P L ++ +D + + K + R K+S + + + Sbjct: 196 LMKTWDHWSIQILDMVPFLRFFPNPGLWRLKQAIENRDHM--VEKQLRRHKESMVAGQWR 253 Query: 267 HRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPD 326 D++ + Q +E L + + + G ETT+S LS+ + L HP+ Sbjct: 254 DMTDYMLQGVGRQRVEEGPG--QLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPE 311 Query: 327 VQQKLQKEIDAVLPNKA---PPTYDAVVQMEYLDMVVNETLRLFPVAI-RLERTCKKDVE 382 +Q++LQ+E+D L A TY ++ L+ + E LRL PV L + Sbjct: 312 IQRRLQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSS 371 Query: 383 INGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCI 442 I G IP+G +V+ H D W +P EFRP+RF + + FG G R C+ Sbjct: 372 IFGYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPS---ALAFGCGARVCL 428 Query: 443 GMRFALMNMKLALIRVLQNFSFKPCKETQIP-LKLDTQ-GLLQPEKPIVLKVDSR 495 G A + + + L R+LQ F+ P +P L+ D G+ +P +++ R Sbjct: 429 GESLARLELFVVLARLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRLQPR 483 >5VBU-A nrPDB Length = 476 Score = 299 bits (766), Expect = 2e-81, Method: Composition-based stats. Identities = 101/472 (21%), Positives = 196/472 (41%), Gaps = 35/472 (7%) Query: 41 PTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYS 100 P P ++L L + +K+G ++ + G V+ + I +VK+ ++ Sbjct: 12 PPLAPGFLHLLQ--PDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKK-WA 68 Query: 101 VFTNRRSLGPVGFMKSAISLAEDEE---------WKRIRSLLSPTFTSGKLKEMFPIIAQ 151 F R + + + WK + L G M P++ Q Sbjct: 69 DFAGRPEP-----LTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQ 123 Query: 152 YGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFL 211 +R A+ G PV +++ F + +I +FG I +N + + ++ L Sbjct: 124 LTQEFCERMR--AQPGTPVAIEEEFSLLTCSIICYLTFGDKIKD-DNLMPAYYKCIQEVL 180 Query: 212 K---FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHR 268 K + + + L F P L ++ +D I + + + K+S + + + Sbjct: 181 KTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHI--VEMQLRQHKESLVAGQWRDM 238 Query: 269 LDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQ 328 +D++ + + +E L + + ++ + G ETT++ LS+ + L HP++Q Sbjct: 239 MDYMLQGVAQPSMEE--GSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQ 296 Query: 329 QKLQKEIDAVLPNKAPPT---YDAVVQMEYLDMVVNETLRLFPVAI-RLERTCKKDVEIN 384 Q+LQ+E+D L A + Y ++ L+ + E LRL PV L + I+ Sbjct: 297 QRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 356 Query: 385 GVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGM 444 G IP+G++++ H D W P EF P+RF + + FG G R C+G Sbjct: 357 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKN---SRALAFGCGARVCLGE 413 Query: 445 RFALMNMKLALIRVLQNFSFKPCKETQIPLK-LDTQGLLQPEKPIVLKVDSR 495 A + + + L R+LQ F+ P + L+ L ++ +P +++ R Sbjct: 414 PLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPR 465 >3MDV-A nrPDB Length = 456 Score = 299 bits (764), Expect = 2e-81, Method: Composition-based stats. Identities = 102/447 (22%), Positives = 200/447 (44%), Gaps = 19/447 (4%) Query: 54 RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNR-----RSL 108 + L + KKYG + + +T P+ ++ L+ Y+ + Sbjct: 9 GRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVF 68 Query: 109 GPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGK 168 G F + +S E W + R ++ F+ L + + + LV L +A+ Sbjct: 69 GERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQT 128 Query: 169 PVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPF 228 PV+++D+ +MD++ +FG+ L Q P ++ K L+ L F Sbjct: 129 PVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEG----ITASRNTLAKF 184 Query: 229 LTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHK 288 L + L + + + + ++ L ++ D L ++ ++ + Sbjct: 185 LPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ----- 239 Query: 289 ALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYD 348 D L + F AG+ET+++ L+FT+ EL+ P++ +LQ E+D V+ +K ++ Sbjct: 240 --DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFE 297 Query: 349 AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 + +++YL V+ E+LRL+P A R +++ I+GV +P + ++ TY + Y+ Sbjct: 298 DLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYF 357 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK 468 +P F P+RF + Y PF G R+CIG +FA M +K+ + ++LQ F+ Sbjct: 358 EDPLTFNPDRF-GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVP 416 Query: 469 ETQIPLKLDTQGLLQPEKPIVLKVDSR 495 + L+ Q L+P P++ + R Sbjct: 417 GQRFGLQ--EQATLKPLDPVLCTLRPR 441 >5UYS-A nrPDB Length = 494 Score = 298 bits (763), Expect = 3e-81, Method: Composition-based stats. Identities = 112/468 (23%), Positives = 200/468 (42%), Gaps = 19/468 (4%) Query: 44 LPLLGNV--LSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSV 101 LPL+G++ L + + KKYG ++ G + + + + VL+K+ Sbjct: 16 LPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKD- 74 Query: 102 FTNRRSLGPVGFM---KSAISLAE-DEEWKRIRSLLSPTFTSGKL--KEMFPIIAQYGDV 155 F+ R + + + I+ A+ W+ R L TF K +++ II Q Sbjct: 75 FSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEIST 134 Query: 156 LVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGF 215 L L G+ + + +VI+ F + + +P+ +++ + + Sbjct: 135 LCDML--ATHNGQSIDISFPVFVAVTNVISLICFNTSYKN-GDPELNVIQNYNEGIIDNL 191 Query: 216 LDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFL--- 272 + ++ + + P + K + L+K + K+ +D + LD L Sbjct: 192 SKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQA 251 Query: 273 QLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQ 332 ++ D+ N+ + + LSD + AG ETT+SV+ +TL L +P V++KL Sbjct: 252 KMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLY 311 Query: 333 KEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRL-ERTCKKDVEINGVFIPKG 391 +EID + PT ++ L+ + E LRL PVA L D I + KG Sbjct: 312 EEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKG 371 Query: 392 SMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDS---IDPYIYTPFGTGPRNCIGMRFAL 448 + V+I +ALHH+ K W +P++F PERF + Y PFG GPR+CIG A Sbjct: 372 TEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILAR 431 Query: 449 MNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRD 496 + L + +LQ F + + Q+P ++ +K+ R Sbjct: 432 QELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQ 479 >3K9V-A nrPDB Length = 482 Score = 297 bits (759), Expect = 9e-81, Method: Composition-based stats. Identities = 123/479 (25%), Positives = 210/479 (43%), Gaps = 41/479 (8%) Query: 37 GIPGPTPLPLLGNVLS--YRQGLWK---FDTECYKKYGKMWGTYEGQLPVLAITDPDVIR 91 +PGPT PLLG++L ++ GL K E +KKYG+++ G + + P ++ Sbjct: 25 DLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLE 84 Query: 92 TVLVKECYSVFTNRRSLGPVGFMK------SAISLAEDEEWKRIRSLLSPTFTSGKLKEM 145 + E S R + P + + + E +EW+R+RS K E+ Sbjct: 85 ALYRTE--SAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLM--KPVEI 140 Query: 146 FPIIAQYGDVLVRNLRREAE----KGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQD 201 + + +VL L R E +G+ L +S + I + L Sbjct: 141 MKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQK--- 197 Query: 202 PFVESTKKFLKFGFLDPLFLSIILFPFLTPV--FEALNVSLFPKDTINF--LSKSVNRMK 257 E+ ++ L F +S +TPV + LN ++ T+ + + KSV Sbjct: 198 ---ETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCI 254 Query: 258 KSRLND-KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSF 316 +RL Q+ DFL + LS EL A A ETT++ L + Sbjct: 255 DNRLQRYSQQPGADFLCDIYQQ---------DHLSKKELYAAVTELQLAAVETTANSLMW 305 Query: 317 TLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERT 376 LY L+ +P Q++L +E+ +VLP+ P + + M YL + E++RL P RT Sbjct: 306 ILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 365 Query: 377 CKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGT 436 K + +PKG+++ + T L + + +FRPER+ +K+ I+P+ + PFG Sbjct: 366 LDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGI 425 Query: 437 GPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495 G R CIG R A + + LAL ++Q + P+++ G+L P + + + R Sbjct: 426 GKRMCIGRRLAELQLHLALCWIIQKYDIVATDNE--PVEMLHLGILVPSRELPIAFRPR 482 >3JUS-A nrPDB Length = 461 Score = 292 bits (748), Expect = 2e-79, Method: Composition-based stats. Identities = 102/465 (21%), Positives = 182/465 (39%), Gaps = 38/465 (8%) Query: 42 TPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVI--------RTV 93 +P+P LG+ +++ + +F Y+KYG ++ + D + Sbjct: 18 SPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDL 77 Query: 94 LVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYG 153 ++ YS T PV F K + + + +L K+ II + Sbjct: 78 NAEDVYSRLTT-----PV-FGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKET 131 Query: 154 DVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKF 213 + EK ++F A S +I S ++ + + + V L Sbjct: 132 KEYFESWGESGEK-------NVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDG 184 Query: 214 GFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQ 273 GF +L P P F + + ++ + K++ + ++S Q+ D LQ Sbjct: 185 GFSHAAWLLPGWLPL--PSFRRRDRA--HREIKDIFYKAIQKRRQS-----QEKIDDILQ 235 Query: 274 LMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQK 333 ++D+ + + L+D E+A I + AG T+S+ ++ + LA +Q+K Sbjct: 236 TLLDAT----YKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYL 291 Query: 334 EIDAVLPNKAPP-TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGS 392 E V PP TYD + + LD + ETLRL P + + R + + G IP G Sbjct: 292 EQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGH 351 Query: 393 MVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID-PYIYTPFGTGPRNCIGMRFALMNM 451 V + W E +F P+R+ + + + Y PFG G CIG FA + + Sbjct: 352 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQI 411 Query: 452 KLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRD 496 K +L+ + F + P T + PE P V++ R Sbjct: 412 KTIWSTMLRLYEFDLI-DGYFPTVNYTTMIHTPENP-VIRYKRRS 454 >6IQ5-A nrPDB Length = 463 Score = 286 bits (732), Expect = 1e-77, Method: Composition-based stats. Identities = 94/459 (20%), Positives = 170/459 (37%), Gaps = 19/459 (4%) Query: 55 QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFM 114 Q ++YG ++ G P++ + I LV++ S F +R S + Sbjct: 1 QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQG-SAFADRPSFASFRVV 59 Query: 115 KSAISLA---EDEEWKRIRS----LLSPTFT--SGKLKEMFPIIAQYGDVLVRNLRREAE 165 S+A E WK R ++ FT + + + LV L R + Sbjct: 60 SGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSA 119 Query: 166 KGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKF---GFLDPLFLS 222 G + + + +V++ FG + + ++F + G L + Sbjct: 120 DGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPW 179 Query: 223 IILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSK 282 + FP L + L K + + R + +D L + + + Sbjct: 180 LQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAG 239 Query: 283 ETESHKALSDLELAAQSIIFIF-AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPN 341 ++ A DLE +I IF A +T S+ L + L +PDVQ ++Q E+D V+ Sbjct: 240 DSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGR 299 Query: 342 KAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEINGVFIPKGSMVVIPTYA 400 P + Y+ + E +R V + + + + G IPK ++V + ++ Sbjct: 300 DRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWS 359 Query: 401 LHHDPKYWTEPEEFRPERFSKKKDSIDP---YIYTPFGTGPRNCIGMRFALMNMKLALIR 457 ++HDP W PE F P RF K I+ F G R CIG + M + L + Sbjct: 360 VNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISI 419 Query: 458 VLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRD 496 + F+ + ++P K + V R+ Sbjct: 420 LAHQCDFRANPNEPAKMNFSYGLTIKP-KSFKVNVTLRE 457 >3TBG-A nrPDB Length = 479 Score = 281 bits (719), Expect = 4e-76, Method: Composition-based stats. Identities = 88/451 (19%), Positives = 156/451 (34%), Gaps = 15/451 (3%) Query: 55 QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFM 114 Q + +++G ++ PV+ + +R LV +R + + Sbjct: 30 QNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDT-ADRPPVPITQIL 88 Query: 115 KSA------ISLAEDEEWKRIRSLLSPTFTSGKL--KEMFPIIAQYGDVLVRNLRREAEK 166 W+ R T + L K + + + L + Sbjct: 89 GFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHS-- 146 Query: 167 GKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILF 226 G+P + +VI + G + + ++ ++ LK + + Sbjct: 147 GRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVP 206 Query: 227 PFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETES 286 L A V F K + L + + + D + D + + + Sbjct: 207 VLLHIPALAGKVLRFQKAFLTQLDELLTEHR--MTWDPAQPPRDLTEAFLAEMEKAKGNP 264 Query: 287 HKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPT 346 + +D L AG TTS+ L++ L + HPDVQ+++Q+EID V+ P Sbjct: 265 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPE 324 Query: 347 YDAVVQMEYLDMVVNETLRLFPVAI-RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDP 405 M Y V++E R + + +D+E+ G IPKG+ ++ ++ D Sbjct: 325 MGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDE 384 Query: 406 KYWTEPEEFRPERFSKKKDSI-DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 464 W +P F PE F + P + PF G R C+G A M + L +LQ+FSF Sbjct: 385 AVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF 444 Query: 465 KPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495 P L P L R Sbjct: 445 SVPTGQPRPSHHGVFAFLVSPSPYELCAVPR 475 >4R1Z-A nrPDB Length = 439 Score = 277 bits (709), Expect = 6e-75, Method: Composition-based stats. Identities = 101/443 (22%), Positives = 184/443 (41%), Gaps = 41/443 (9%) Query: 76 EGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFM---KSAISLAE-DEEWKRIRS 131 G +L + + + +L+K+ +F R + I+ A+ WK R Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGK-IFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRK 59 Query: 132 LLSPT---FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTS 188 ++ F G + + II + + L + V L +V+ Sbjct: 60 MVHGALCMFGEGSV-SIEKIICREASSMCEVLTES--QNSAVDLGPELTRAVTNVVCALC 116 Query: 189 FGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINF 248 F + + + ++ ++ + D L + +FP+L +FP + Sbjct: 117 FNSSYKRGDAEFESMLQYSQGIVDTVAKDSL---VDIFPWL---------QIFPNKDLTI 164 Query: 249 LSKSVNRMKKSRLNDKQKH--------RLDFLQLMIDSQNSKETESHKA----LSDLELA 296 L + ++ K ++H + D L ++ ++ S E + L++ + Sbjct: 165 LRQCISIRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVL 224 Query: 297 AQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYL 356 AG ETT++VL +++ L +P VQ+K+Q+E+D+ + + P + YL Sbjct: 225 MTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYL 284 Query: 357 DMVVNETLRLFPVAIRL-ERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFR 415 + + E LR+ PV+ L +D + + KG+ VVI ++LHHD K W PE F Sbjct: 285 EATIREVLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFD 344 Query: 416 PERFSKKKDSI---DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQI 472 P RF ++ Y PFG G R C+G A M + L L +LQ F+ + + Sbjct: 345 PGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPL 404 Query: 473 P-LKLDTQGLLQPEK-PIVLKVD 493 P L+ +LQP+K +V KV Sbjct: 405 PDLQGKFGVVLQPKKFKVVAKVR 427 >4KPA-A nrPDB Length = 494 Score = 268 bits (684), Expect = 5e-72, Method: Composition-based stats. Identities = 120/477 (25%), Positives = 205/477 (42%), Gaps = 23/477 (4%) Query: 31 GLFKRLGIPGPTPLPLLGNVLSYRQG-LWKFDTECYKKYGKMWGTYEGQLPVLAITDPDV 89 G +P P L N+ + + + G+++ ++ + Sbjct: 22 GAMTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRL 81 Query: 90 IRTVLVKECYSVFTNRRSLGPVGFMKSAI--SLAEDEEWKRIRSLLSPTFTSGKLKEMFP 147 I+ + + ++ F + S ++ WK+ ++L P+F+ +K Sbjct: 82 IKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHA 141 Query: 148 IIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ-DPFVES 206 ++ LV+ R + + + + ++D I F +S Q PF+ S Sbjct: 142 MMVDIAVQLVQKWER-LNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITS 200 Query: 207 TKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQK 266 + L D + P ++ ++ I ++ V+++ R ++ Sbjct: 201 MVRAL-----DEAMNKLQRANPDDPAYDENKRQF--QEDIKVMNDLVDKIIADRKASGEQ 253 Query: 267 HRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPD 326 D L M+ N K+ E+ + L D + Q I F+ AG+ETTS +LSF LY L +P Sbjct: 254 S-DDLLTHML---NGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPH 309 Query: 327 VQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEING- 385 V QK +E VL + P+Y V Q++Y+ MV+NE LRL+P A K+D + G Sbjct: 310 VLQKAAEEAARVLVDPV-PSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGE 368 Query: 386 VFIPKGSMVVIPTYALHHDPKYW-TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGM 444 + KG +++ LH D W + EEFRPERF +I + + PFG G R CIG Sbjct: 369 YPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENP-SAIPQHAFKPFGNGQRACIGQ 427 Query: 445 RFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSG 501 +FAL L L +L++F F+ T L + L+PE V+K S+ L G Sbjct: 428 QFALHEATLVLGMMLKHFDFE--DHTNYELDIKETLTLKPEG-FVVKAKSKKIPLGG 481 >3EL3-A nrPDB Length = 467 Score = 263 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 82/430 (19%), Positives = 168/430 (39%), Gaps = 20/430 (4%) Query: 42 TPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSV 101 +PLLG+ + F ++ + +G + G V A+T+P++ + + Y + Sbjct: 29 GGVPLLGHGWRLARDPLAFMSQL-RDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHI 87 Query: 102 FTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLR 161 K ++ A +R R + P F + PI+ + L + Sbjct: 88 AGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQ 147 Query: 162 REAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL 221 GK V ++ V ++ + + + + + Sbjct: 148 ----PGKTVDATSESFRVAVRVAARCLL--RGQYMDERAERLCVALATVFRGMYRRMVVP 201 Query: 222 SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNS 281 L+ P N D + L V+ + R QK D L ++++++ Sbjct: 202 LGPLYRLPLPANRRFN------DALADLHLLVDEIIAERRASGQKP-DDLLTALLEAKD- 253 Query: 282 KETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPN 341 ++ + + E+ Q + + G ET +S + + L LA HP+ +++ E++AV Sbjct: 254 ---DNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGG 310 Query: 342 KAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYAL 401 P ++ V ++ + V+ E +RL P L R + E+ G IP G+ ++ YA+ Sbjct: 311 -RPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAI 369 Query: 402 HHDPKYWTEPEEFRPERFS-KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQ 460 DPK + + EF P+R+ ++ ++ Y PF G R C F++ + L + Sbjct: 370 QRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALAT 429 Query: 461 NFSFKPCKET 470 + F+ + Sbjct: 430 KYRFEQVAGS 439 >5OFQ-A nrPDB Length = 409 Score = 260 bits (665), Expect = 7e-70, Method: Composition-based stats. Identities = 75/414 (18%), Positives = 161/414 (38%), Gaps = 69/414 (16%) Query: 84 ITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLK 143 + D + ++ +L S+F+++R++ + +I + + + ++R+L++ FT ++ Sbjct: 54 VFDYETVKYILKNP--SLFSSKRAMEE---RQESILMMDPPKHTKLRNLVNKAFTPRAIQ 108 Query: 144 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF 203 + I + D L+ + + + + + F ++ GV I Sbjct: 109 HLEGHIEEIADYLLDEVSSK----EKFDIVEDFAGPLPIIVIAELLGVPIQ--------- 155 Query: 204 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND 263 + L + D L F + + + FL + R + Sbjct: 156 ----DRALFKKYSDDLVSGAE--NNSDEAFAKMMQKR--NEGVIFLQGYFKEIIAERQQN 207 Query: 264 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT 323 KQ+ D + L+++++ E L++ E+ I+ + AG ETT+++++ + + Sbjct: 208 KQE---DLISLLLEAEIDGE-----HLTEEEVLGFCILLLVAGNETTTNLITNGVRYMTE 259 Query: 324 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 383 DVQ +++++I + +V ETLR +P + R +DVE+ Sbjct: 260 DVDVQNEVRRDIS------------------LVPNLVEETLRYYPPIQAIGRIAAEDVEL 301 Query: 384 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG 443 I +G V+ + + D + P+ F R + + FG G C+G Sbjct: 302 GECKIKRGQQVISWAASANRDSAKFEWPDTFVVHRKT--------NPHVSFGFGIHFCLG 353 Query: 444 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDG 497 A M K+A ++L+ F K+ Q L + P V V + Sbjct: 354 APLARMEGKIAFTKLLEKGGFS---------KVQNQSLKPIDSPFVFGVKKYEI 398 >3N9Z-A nrPDB Length = 487 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 105/488 (21%), Positives = 189/488 (38%), Gaps = 38/488 (7%) Query: 26 GTRTHGLFKRLGIPGPTPLPLLGNVLSYRQG--LWKFDTECYKKYGKMWGTYEGQLPVLA 83 TR+ F + PG L + + + ++KYG ++ G + + Sbjct: 1 STRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVY 60 Query: 84 ITDPDVIRTVLVKECYSVFTNRRSLGPVGF------MKSAISLAEDEEWKRIR-----SL 132 + DP+ + + E + R + P + L + WK+ R + Sbjct: 61 VIDPEDVALLFKSEGPN--PERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEV 118 Query: 133 LSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVN 192 ++P T L + + + VL R +++ + D ++ + IT FG Sbjct: 119 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 178 Query: 193 I----DSLNNPQDPFVESTKKFLKFGF----LDPLFLSIILFPFLTPVFEALNVSLFPKD 244 + +N F+++ + L P + A +V D Sbjct: 179 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 238 Query: 245 TINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF 304 R K S +D +R +L+ DS+ +S ++ A + Sbjct: 239 IYTQNFYWELRQKGSVHHD---YRGILYRLLGDSK----------MSFEDIKANVTEMLA 285 Query: 305 AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETL 364 G +TTS L + LYE+A + VQ L+ E+ A + + L + ETL Sbjct: 286 GGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETL 345 Query: 365 RLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKD 424 RL P+++ L+R D+ + IP ++V + YAL +P ++ +PE F P R+ K Sbjct: 346 RLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDK 405 Query: 425 SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQP 484 +I + FG G R C+G R A + M + LI +L+NF + + + +L P Sbjct: 406 NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTF--NLILMP 463 Query: 485 EKPIVLKV 492 EKPI Sbjct: 464 EKPISFTF 471 >5VWS-A nrPDB Length = 393 Score = 254 bits (648), Expect = 8e-68, Method: Composition-based stats. Identities = 78/416 (18%), Positives = 154/416 (37%), Gaps = 66/416 (15%) Query: 51 LSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFT-NRRSLG 109 L+ + +W G + + D +R +L Y F+ +R L Sbjct: 13 LTDGGAALFAWLRTMRNEHPVWRDQFG---IYHVFRYDDVRQILGD--YQTFSSDRTRLM 67 Query: 110 PV--GFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKG 167 P GF K I++ + E + R L++ FT + M P I Q D L+ L G Sbjct: 68 PTAQGFGKGGITMIDPPEHRHQRRLITHAFTPQSISAMEPRIRQIADHLLDEL-----PG 122 Query: 168 KPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFP 227 L + F ++ GV + L + D +S+ + Sbjct: 123 PEFDLVEHFAYPLPVIVIAELLGVP-------------PGDRHLFRTWSD-RLMSLQVEN 168 Query: 228 FLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESH 287 + P + +++ + +++ + + R D L ++ ++ Sbjct: 169 YADPEL--------ARTVAAAMTEMNDYLREHCRSRRTHPRDDLLTRLVQAEV-----EG 215 Query: 288 KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTY 347 K L E+ + + + AG+ TT+ ++ T+ L HP+ ++ ++ + Sbjct: 216 KRLDLEEVVNTASLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVRAD------------- 262 Query: 348 DAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKY 407 + + E+LRL ++ R +DV I G IP V+ + +HD + Sbjct: 263 -----PSLIPAALEESLRLRSPFLQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRR 317 Query: 408 WTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 + +PE F R + + FG G C+G + + ++AL R+L F+ Sbjct: 318 FPDPERFDLHRQTTG--------HIAFGHGVHFCLGAQLGRLEGRIALERLLGRFT 365 >4WMZ-A nrPDB Length = 539 Score = 250 bits (639), Expect = 8e-67, Method: Composition-based stats. Identities = 92/489 (18%), Positives = 168/489 (34%), Gaps = 37/489 (7%) Query: 32 LFKRLGIPGPTPL-PLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDP--- 87 ++ P P +G+ + Y ++F EC KKYG ++ + P Sbjct: 50 SLRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGH 109 Query: 88 DVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFP 147 + + + + + PV F K I + + + T K P Sbjct: 110 EFVFNAKLADVSAEAAYAHLTTPV-FGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVP 168 Query: 148 IIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVEST 207 +IA+ R+ + + D+ I F + L +++ Sbjct: 169 LIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTI----FTASRSLLGKEMRAKLDTD 224 Query: 208 KKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKH 267 +L + LD F I P+ K + +K + Sbjct: 225 FAYL-YSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRK----NNDIQ 279 Query: 268 RLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDV 327 D + ++ + + ++D E+A I + G T+++ ++ L LA PDV Sbjct: 280 DRDLIDSLM---KNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDV 336 Query: 328 QQKLQKEIDAVL-PNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI--N 384 QQ+L +E VL K TYD + +M L+ + ETLR+ L R KD+ + Sbjct: 337 QQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNT 396 Query: 385 GVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDP---------------- 428 IP G V++ H +Y+ +F R++ S Sbjct: 397 SYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGV 456 Query: 429 -YIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKP 487 Y PFG G CIG FA + + + ++ + + +P T + P P Sbjct: 457 SSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGP 516 Query: 488 IVLKVDSRD 496 + + R+ Sbjct: 517 AKIIWEKRN 525 >4RM4-A nrPDB Length = 396 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 76/427 (17%), Positives = 145/427 (33%), Gaps = 77/427 (18%) Query: 41 PTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYS 100 P P S R+ E + +W + + D ++ + + ++ S Sbjct: 26 PFPW-----YESMRKDAPVSFDEENQ----VWSVFLYDDVKKVVGDKELFSSCMPQQTSS 76 Query: 101 VFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNL 160 + ++I + + +IRS+++ FT +K+ P I + D L++ Sbjct: 77 -------------IGNSIINMDPPKHTKIRSVVNKAFTPRVMKQWEPRIQEITDELIQKF 123 Query: 161 RREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLF 220 + +E L F ++ GV + + D L Sbjct: 124 QGRSE----FDLVHDFSYPLPVIVISELLGVPSAHMEQ-------------FKAWSDLLV 166 Query: 221 LSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQN 280 + ++ F + + + K D + ++++++ Sbjct: 167 STPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKR-------NKPEQDIISILVEAEE 219 Query: 281 SKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLP 340 + E LS EL + + AG ETT++++S +Y + P V ++L+ Sbjct: 220 TGEK-----LSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELR-------- 266 Query: 341 NKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYA 400 E + V E LR A L R K+D EI G I +G MV+ + Sbjct: 267 ----------SHPELMPQAVEEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVAS 316 Query: 401 LHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQ 460 + D + P F R P + FG G C+G A + +AL ++ Sbjct: 317 ANRDEAKFDRPHMFDIRR--------HPNPHIAFGHGIHFCLGAPLARLEANIALTSLIS 368 Query: 461 NFSFKPC 467 F C Sbjct: 369 AFPHMEC 375 >5JLC-A nrPDB Length = 515 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 98/507 (19%), Positives = 185/507 (36%), Gaps = 39/507 (7%) Query: 15 LAVSLVLLYLYGTRTHGLFKRLGIPGPTPL-PLLGNVLSYRQGLWKFDTECYKKYGKMWG 73 + V+L +Y + ++ P P +G+ + Y ++F +C KKYG ++ Sbjct: 15 IMVALPFVYTITWQLLYSLRKDRPPLVFYWIPWVGSAIPYGTKPYEFFEDCQKKYGDIFS 74 Query: 74 TYEGQLPVLAITDP---DVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIR 130 + P + I + + + PV F K I + + Sbjct: 75 FMLLGRIMTVYLGPKGHEFIFNAKLADVSAEAAYSHLTTPV-FGKGVIYDCPNHRLMEQK 133 Query: 131 SLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFG 190 + T P+IA+ RN + + D+ + I F Sbjct: 134 KFVKGALTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTI----FT 189 Query: 191 VNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLS 250 + L +++ +L + LD F + I F F E + I+ Sbjct: 190 ASRSLLGKEMRDKLDTDFAYL-YSDLDKGF-TPINFVFPNLPLEHYRKRDHAQQAISGTY 247 Query: 251 KSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETT 310 S+ + ++ + + + + +D + + + ++D E+A I + G T+ Sbjct: 248 MSLIKERREKNDIQNRDLID------ELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTS 301 Query: 311 SSVLSFTLYELATHPDVQQKLQKEIDAVLPNK-APPTYDAVVQMEYLDMVVNETLRLFPV 369 ++ ++ L LA PDVQ++L +E VL N TYD + M L+ ++ ETLRL Sbjct: 302 AATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHP 361 Query: 370 AIRLERTCKKDVEI--NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID 427 L R +DV I +P+ V++ H +++ +P EF R+ S Sbjct: 362 LHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSS 421 Query: 428 ------------------PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK-PCK 468 Y PFG G CIG FA + + + ++ ++ P + Sbjct: 422 AAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTE 481 Query: 469 ETQIPLKLDTQGLLQPEKPIVLKVDSR 495 +P T + P P + + R Sbjct: 482 GETVPPSDFTSMVTLPTAPAKIYWEKR 508 >5XNT-A nrPDB Length = 411 Score = 247 bits (630), Expect = 9e-66, Method: Composition-based stats. Identities = 93/446 (20%), Positives = 171/446 (38%), Gaps = 67/446 (15%) Query: 52 SYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPV 111 ++ + + + D Y + W ++ + ++D +V + SV T+ Sbjct: 24 AWCKRMLENDPVSYHEGTDTWNVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVP 83 Query: 112 GFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT 171 +K I+ A+ E ++ RSLL+ FT L+ P I + D L+ + E E + Sbjct: 84 DKIK--ITEADPPEHRKRRSLLAAAFTPRSLQNWEPRIQEIADELIEEMDEETE----ID 137 Query: 172 LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTP 231 + + ++ GV S + L ++D LFL PF Sbjct: 138 IVQSLASPLPIIVMSDLMGVP-------------SKDRLLFKKWVDILFL-----PFDKE 179 Query: 232 VFEALN--VSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKA 289 E +N + K+ +L V + + D + ++ ++ E Sbjct: 180 KQEEVNELKQVAAKEYYQYLYPIVVQKR-------LNPADDIISDLLKAEVDGE-----M 227 Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELA-THPDVQQKLQKEIDAVLPNKAPPTYD 348 +D E+ +++ + AG ETTS +L+ + Y L +V Q+L + +D Sbjct: 228 FTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLD------------ 275 Query: 349 AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 + V E LR I+L+RT K+D ++ GV + +G VV+ A + D + + Sbjct: 276 ------LVPQAVEEMLRYRFNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMF 329 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF---SFK 465 + R + KK + FG GP C+G A + K+AL L+ F Sbjct: 330 EDAFTLNIHRPNNKK-------HLTFGNGPHFCLGAPLARLEAKIALTTFLKKFKHIEAV 382 Query: 466 PCKETQIPLKLDTQGLLQPEKPIVLK 491 P + + L G P+ Sbjct: 383 PSFQLEDNLTDSATGQTLTSLPLKAC 408 >3S79-A nrPDB Length = 503 Score = 244 bits (623), Expect = 6e-65, Method: Composition-based stats. Identities = 91/440 (20%), Positives = 180/440 (40%), Gaps = 27/440 (6%) Query: 38 IPGPTPLPLLGNVLSYRQGLWK---FDTECYKK-YGKMWGTYEGQLPVLAITDPDVIRTV 93 IPGP +G ++S+ + LW Y + YG+ + L I+ + + Sbjct: 47 IPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHI 106 Query: 94 LVKECYS-VFTNRRSLGPVGFMKSAISLAEDEE-WKRIRSLLSPTFTSGKLKEMFPIIAQ 151 + YS F ++ L +G + I + E WK R + L M + A+ Sbjct: 107 MKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAE 166 Query: 152 YGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFL 211 + L + V + + +D + +D K Sbjct: 167 SLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAI-------VVKIQG 219 Query: 212 KFGFLDPLFLSIILFPFLTPVFEALNVSLFP-KDTINFLSKSVNRMKKSRLNDKQKHRLD 270 F L + +F ++ +++ S+ KD I L + ++ +K + +D Sbjct: 220 YFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVL--IAEKRRRISTEEKLEECMD 277 Query: 271 FLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQK 330 F +I ++ + L+ + + + A +T S L F L+ +A HP+V++ Sbjct: 278 FATELILAEKRGD------LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEA 331 Query: 331 LQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPK 390 + KEI V+ + D + +++ ++ + E++R PV + R +D I+G + K Sbjct: 332 IIKEIQTVIGERDIK-IDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKK 390 Query: 391 GSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMN 450 G+ +++ +H ++ +P EF E F+K ++ + PFG GPR C G A++ Sbjct: 391 GTNIILNIGRMHRLE-FFPKPNEFTLENFAK---NVPYRYFQPFGFGPRGCAGKYIAMVM 446 Query: 451 MKLALIRVLQNFSFKPCKET 470 MK L+ +L+ F K + Sbjct: 447 MKAILVTLLRRFHVKTLQGQ 466 >4YT3-A nrPDB Length = 410 Score = 244 bits (623), Expect = 6e-65, Method: Composition-based stats. Identities = 90/443 (20%), Positives = 172/443 (38%), Gaps = 67/443 (15%) Query: 52 SYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPV 111 ++ + + + D Y + W ++ + ++D +V + SV T+ Sbjct: 24 AWCKRMLENDPVSYHEGTDTWNVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVP 83 Query: 112 GFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT 171 ++ I+ ++ + ++ RSLL+ FT L+ P I + D L+ + + G + Sbjct: 84 EKIQ--ITESDPPDHRKRRSLLAAAFTPRSLQNWEPRIQEIADELIGQM----DGGTEID 137 Query: 172 LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTP 231 + + ++ GV S + L ++D LFL PF Sbjct: 138 IVASLASPLPIIVMADLMGVP-------------SKDRLLFKKWVDTLFL-----PFDRE 179 Query: 232 VFEALNV--SLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKA 289 E ++ + K+ +L V + + D + ++ S+ E Sbjct: 180 KQEEVDKLKQVAAKEYYQYLYPIVVQKR-------LNPADDIISDLLKSEVDGE-----M 227 Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELA-THPDVQQKLQKEIDAVLPNKAPPTYD 348 +D E+ +++ + AG ETTS +L+ + Y L +V Q+L + +D Sbjct: 228 FTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLD------------ 275 Query: 349 AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 + V E LR I+L+RT K+D ++ GV + +G VV+ A + D + + Sbjct: 276 ------LVPQAVEEMLRFRFNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMF 329 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF---SFK 465 +P R + KK + FG GP C+G A + K+AL L+ F Sbjct: 330 EDPFTLNIHRPNNKK-------HLTFGNGPHFCLGAPLARLEAKIALTAFLKKFKHIEAV 382 Query: 466 PCKETQIPLKLDTQGLLQPEKPI 488 P + + L G P+ Sbjct: 383 PSFQLEENLTDSATGQTLTSLPL 405 >3MZS-A nrPDB Length = 486 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 92/492 (18%), Positives = 189/492 (38%), Gaps = 39/492 (7%) Query: 24 LYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFD--TECYKKYGKMWGTYEGQLPV 81 + T+T + + PG L + + E ++KYG ++ G L Sbjct: 1 MASTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLES 60 Query: 82 LAITDPDVIRTVLVKECYSVFTNRRSLGPVGFM------KSAISLAEDEEWKRIR----- 130 + I P+ + + E + R + P + + WK+ R Sbjct: 61 VYIIHPEDVAHLFKFEG--SYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNT 118 Query: 131 SLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFG 190 +++P + + P+ + +L + ++++ +K+ ++ + IT FG Sbjct: 119 EVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFG 178 Query: 191 VNI----DSLNNPQDPFVESTKKFLKFGF----LDPLFLSIILFPFLTPVFEALNVSLFP 242 + +++N F+++ K + P + A + Sbjct: 179 ERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNK 238 Query: 243 KDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIF 302 + + + R + ++ L ++ S+ + ++ A Sbjct: 239 AEKYTEIF-----YQDLRRKTEFRNYPGILYCLLKSEK---------MLLEDVKANITEM 284 Query: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362 + G TTS L + LYE+A +VQ+ L++E+ + + L + E Sbjct: 285 LAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKE 344 Query: 363 TLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422 TLRL P+++ L+R + D+ + IP ++V + YA+ DP +++ P++F P R+ K Sbjct: 345 TLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSK 404 Query: 423 KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLL 482 + + FG G R C+G R A + M L LI +L+NF + + +L Sbjct: 405 DKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIF--NLIL 462 Query: 483 QPEKPIVLKVDS 494 P+KPI L Sbjct: 463 TPDKPIFLVFRP 474 >6AYB-A nrPDB Length = 466 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 95/462 (20%), Positives = 185/462 (40%), Gaps = 21/462 (4%) Query: 41 PTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLV--KEC 98 P +P +G+ +S+ + +F + KKYG ++ + + P ++ T Sbjct: 16 PNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLNHPKILDTFFKATDNE 75 Query: 99 YSVFTNRRSLGPVGFMKSAISLAED-EEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLV 157 S+ R + PV F + A+ E +S T+ + + I D + Sbjct: 76 LSLRDVYRFMRPV-FGTGVVYDADSTERMMEQVKFVSSGLTTARFRVFVDIFE---DEIA 131 Query: 158 RNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLD 217 ++ +G V + ++ + + G + + E L D Sbjct: 132 HKVKELGPEGT-VDVAELMADLIIFTASRCLLG------DEVRQYLSEKNLGKLYHDIDD 184 Query: 218 PLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMID 277 + +P L + L K KK + ++D + ++ Sbjct: 185 GISPLSFFYPSLPAPKRDKARKAVGEIFQELLDKRREEHKKHPERLLDESKMDVVDHLLT 244 Query: 278 SQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDA 337 + + + L+D+ I +FAG T+S S+TL + ++ V +K++KE + Sbjct: 245 QK----YKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEE 300 Query: 338 VLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIP 397 ++ + YD V++M+YL+ + E LR++P I + R +K E IPKG+++V+ Sbjct: 301 IMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQYIIPKGNILVVS 360 Query: 398 TYALHHDPKYWTEPEEFRPERFSKKKDSID-PYIYTPFGTGPRNCIGMRFALMNMKLALI 456 +T P+ F PER +++K+ Y PFG G CIG FAL+ +K + Sbjct: 361 PSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHKCIGENFALLQVKSIIS 420 Query: 457 RVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGT 498 +L+ F + + P T ++ P P ++ R Sbjct: 421 ILLRYFDMEYIGKIPDP--SYTSLVVGPSPPTRMRYKLRKQQ 460 >2W0A-A nrPDB Length = 455 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 85/453 (18%), Positives = 169/453 (37%), Gaps = 20/453 (4%) Query: 48 GNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRS 107 G++ +R + G + V+ ++ + + Sbjct: 17 GHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAY 76 Query: 108 LGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKG 167 A+ E +R L + ++K I ++ + E Sbjct: 77 PFMTPIFGEAVVFDASPE-RRKEMLHNAALRGEQMKGHAATIEDQVRRMIADWGEAGE-- 133 Query: 168 KPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFP 227 + L D F ++ + G + F + + + DPL P Sbjct: 134 --IDLLDFFAELTIYTSSACLIGKKFR--DQLDGRFAKLYHELERG--TDPLAYVDPYLP 187 Query: 228 FLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESH 287 F + + + ++ +N + D K D L ++I + Sbjct: 188 I--ESFRRRDEAR--NGLVALVADIMNGRIANPPTD--KSDRDMLDVLIAVKAET---GT 238 Query: 288 KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTY 347 S E+ I +FAG+ T+S S+TL EL H D + E+D + + ++ Sbjct: 239 PRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSF 298 Query: 348 DAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKY 407 A+ Q+ L+ V+ ETLRL P I L R K + E+ G I +G +V + P+ Sbjct: 299 HALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPED 358 Query: 408 WTEPEEFRPERFS--KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK 465 + +P +F P R+ +++D ++ + + PFG G C+G FA+M +K +L+ + F+ Sbjct: 359 FPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFE 418 Query: 466 PCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGT 498 + + ++ ++Q +P ++ R G Sbjct: 419 MAQPPESYRNDHSKMVVQLAQPAAVRYRRRTGV 451 >5L94-A nrPDB Length = 410 Score = 241 bits (615), Expect = 6e-64, Method: Composition-based stats. Identities = 78/404 (19%), Positives = 158/404 (39%), Gaps = 63/404 (15%) Query: 84 ITDPDVIRTVLVKECYSVFTNRRSLGPVG---FMKSAISLAEDEEWKRIRSLLSPTFTSG 140 + D ++ VL E ++F++ R + +++ + + +R+L++ FT Sbjct: 49 VFHYDGVKEVL--EQKNIFSSDRRPPQNQRQTALGTSLINIDPPKHAEMRALVNKAFTPK 106 Query: 141 KLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200 +K P IA+ + L++ + + + + + ++ GV Sbjct: 107 AMKAWEPKIARITNELLQEVEHLED----IDIVEHLSYPLPVMVIADILGVP-------- 154 Query: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSR 260 +E ++F + + S L + + + D + + K++R Sbjct: 155 ---IEDQRQFKDWSDIIVAGPSNNERETLEKLQQE---KMKANDELETYFYRIIEEKRTR 208 Query: 261 LNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYE 320 D D + +++ ++ E K L+D E+ SI+ + AG ETT++++S T+Y Sbjct: 209 PGD------DIISVLLQAK-----EEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIYC 257 Query: 321 LATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKD 380 L ++L++E E L + E LR L R K+D Sbjct: 258 LMEDKASFERLKRE------------------KELLPSGIEEVLRYRSPVQALHRIVKED 299 Query: 381 VEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRN 440 V + G + G VV + H D +Y+ +PE F+ +R P ++ FG G Sbjct: 300 VTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR--------KPNVHMAFGRGIHF 351 Query: 441 CIGMRFALMNMKLALIRVLQNF---SFKPCKETQIPLKLDTQGL 481 C+G A + K+ L ++ + + P E + GL Sbjct: 352 CLGAPLARIEAKIMLAELIDRYPQMDWSPSFELKPIESTFVYGL 395 >3EJB-B nrPDB Length = 404 Score = 241 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 74/446 (16%), Positives = 153/446 (34%), Gaps = 65/446 (14%) Query: 52 SYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGP- 110 + + + F + ++ + P +T + +L + V T Sbjct: 10 EFLKNPYSFYDTLRAVH-PIYKGSFLKYPGWYVTGYEETAAILKDARFKVRTPLPESSTK 68 Query: 111 ----VGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEK 166 + + +R+R+L S FT + P I + L+ ++ Sbjct: 69 YQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTPRTTESYQPYIIETVHHLLDQVQ----- 123 Query: 167 GKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILF 226 G M+VI+ +F + + N E ++ ++ + I F Sbjct: 124 ----------GKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKEWA---ASLIQTIDF 170 Query: 227 PFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETES 286 N + + + + + + K+ + D + +++ + + Sbjct: 171 TRSRKALTEGN--IMAVQAMAYFKELIQKRKRH-------PQQDMISMLLKGREKDK--- 218 Query: 287 HKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPT 346 L++ E A+ I+ AG+ETT +++S ++ L HP+ KL++ D Sbjct: 219 ---LTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPD---------- 265 Query: 347 YDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPK 406 + V E LR R +D++I GV I +G V + A + DP Sbjct: 266 --------LIGTAVEECLRYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPS 317 Query: 407 YWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466 +T P+ F R P + FG G C+G A + ++A+ +LQ Sbjct: 318 IFTNPDVFDITR--------SPNPHLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLN 369 Query: 467 CKETQIPLKLDTQGLLQPEKPIVLKV 492 + + + E P+ + Sbjct: 370 LADFEWRYRPLFGFRALEELPVTFEA 395 >2Y5N-A nrPDB Length = 417 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 81/413 (19%), Positives = 156/413 (37%), Gaps = 69/413 (16%) Query: 84 ITDPDVIRTVLVKECYSVFTNRRSLGPV---GFMKSAISLAEDEEWKRIRSLLSPTFTSG 140 +T + +R VL + + P +K + + E R+R L+ FT+ Sbjct: 66 VTRYEDVRAVLGDGRFVRGPSMTRDEPRTRPEMVKGGLLSMDPPEHSRLRRLVVKAFTAR 125 Query: 141 KLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200 + + + P + LV + A G+P L +F + GV + Sbjct: 126 RAESLRPRAREIAHELVDQM---AATGQPADLVAMFARQLPVRVICELLGVP----SADH 178 Query: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSR 260 D F + FL T A + + ++ ++R +K Sbjct: 179 DRFTRWSGAFLS-----------------TAEVTAEEMQEAAEQAYAYMGDLIDRRRK-- 219 Query: 261 LNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYE 320 + D + ++ +++ +++ LS+ EL +I + AGYE+T++ ++ +Y Sbjct: 220 -----EPTDDLVSALVQARDQQDS-----LSEQELLDLAIGLLVAGYESTTTQIADFVYL 269 Query: 321 LATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP--VAIRLERTCK 378 L T P+++++L + + E + V E R P V R Sbjct: 270 LMTRPELRRQL------------------LDRPELIPSAVEELTRWVPLGVGTAFPRYAV 311 Query: 379 KDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGP 438 +DV + GV I G V+ T A + D + + + +R P + FG G Sbjct: 312 EDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDR--------TPNQHLGFGHGV 363 Query: 439 RNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQP--EKPIV 489 +C+G A + +++AL +LQ + L+ LL+ E P+V Sbjct: 364 HHCLGAPLARVELQVALEVLLQRLPGIRLGIPETQLRWSEGMLLRGPLELPVV 416 >5FSA-A nrPDB Length = 490 Score = 237 bits (605), Expect = 7e-63, Method: Composition-based stats. Identities = 86/483 (17%), Positives = 169/483 (34%), Gaps = 43/483 (8%) Query: 44 LPLLGNVLSYRQGLWKFDTECYKKYGKMWG-TYEGQLPVLAIT--DPDVIRTVLVKECYS 100 +P G+ SY Q ++F C +KYG ++ G++ + + + + + + + Sbjct: 13 IPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSA 72 Query: 101 VFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNL 160 + PV F I + + T+ K P I + Sbjct: 73 EEAYKHLTTPV-FGTGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTD 131 Query: 161 RREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLF 220 K K + ++ I S + D + D L GF F Sbjct: 132 ESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINF 191 Query: 221 LSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQN 280 + L P + + + K K + ++ D + +D L+I S Sbjct: 192 VFPNL---PLPHYWRRDAA--QKKISATYMKEIKLRRERGDIDPNRDLID--SLLIHST- 243 Query: 281 SKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL- 339 + ++D E+A I + G T++S ++ L L P +Q + +E+ +L Sbjct: 244 ---YKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLK 300 Query: 340 ---PNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI--NGVFIPKGSMV 394 + TY+ + ++ ++ + ETLR+ + R + I +PKG V Sbjct: 301 EKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYV 360 Query: 395 VIPTYALHHDPKYWTEPEEFRPERFSKKKDSID---------------------PYIYTP 433 ++ H +Y+ PE+F P R+ + Y P Sbjct: 361 LVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLP 420 Query: 434 FGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVD 493 FG G CIG +FA + + L + N + ++P + ++ P +P + + Sbjct: 421 FGGGRHRCIGEQFAYVQLGTILTTFVYNLRW-TIDGYKVPDPDYSSMVVLPTEPAEIIWE 479 Query: 494 SRD 496 R+ Sbjct: 480 KRE 482 >2WX2-A nrPDB Length = 473 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 86/464 (18%), Positives = 175/464 (37%), Gaps = 30/464 (6%) Query: 41 PTPLPLLGNVLSYRQGLWKFDTECYKKYGK-MWGTYEGQLPVLAITDPDVIRTVLVKECY 99 P +P LG+++ + + +F C + ++ G V + DP + Sbjct: 22 PVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDP-HEHSRFFSPRN 80 Query: 100 SVFTNRR--SLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLV 157 + + R ++ F + A + + L+ T K + P I + Sbjct: 81 EILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFM 140 Query: 158 RNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLD 217 +E E + L + GA ++ FG ++ N + F + K Sbjct: 141 AENWKEDEG--VINLLEDCGAMIINTACQCLFGEDLRKRLNARH-FAQLLSKM-----ES 192 Query: 218 PLFLSIILFPFLTPV-FEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMI 276 L + + P+L + + + + + ++ K + D L ++ Sbjct: 193 SLIPAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGLL 252 Query: 277 DSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT--HPDVQQKLQKE 334 + +S E+ + +FAG T++ S+++ L + KL KE Sbjct: 253 KAV----YRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKE 308 Query: 335 IDAVLPNKAPPTYDAVV-QMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSM 393 ID A YD V+ +M + + V E++R P + + R K +V++ +PKG + Sbjct: 309 IDEF---PAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDI 365 Query: 394 VVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKL 453 + HHD + + P + PER K + + FG G CIG +FAL+ +K Sbjct: 366 IACSPLLSHHDEEAFPNPRLWDPERDEKVDGA-----FIGFGAGVHKCIGQKFALLQVKT 420 Query: 454 ALIRVLQNFSFKPCKETQIPLKLDTQGLLQPE-KPIVLKVDSRD 496 L + + F+ ++ ++P ++ P ++K + Sbjct: 421 ILATAFREYDFQLLRD-EVPDPDYHTMVVGPTLNQCLVKYTRKK 463 >5CJE-A nrPDB Length = 393 Score = 235 bits (600), Expect = 3e-62, Method: Composition-based stats. Identities = 85/459 (18%), Positives = 161/459 (35%), Gaps = 79/459 (17%) Query: 47 LGNVLSYRQ-------GLWKFDTECYKKYGKMWGTYEGQLPVL---AITDPDVIRTVLVK 96 +GNV+ + + E ++ G + + + R L Sbjct: 1 MGNVIDLGEYGARFTEDPYPVYAELRER-GPVHWVRTPPPEAFEGWLVVGHEEARAALAD 59 Query: 97 ECYSVFTNRRSLGPVGF--MKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGD 154 S ++ L + M + + + E R+RSL++ FT +++ + P I + D Sbjct: 60 PRLSKDGTKKGLTSLDVELMGPYLLVVDPPEHTRLRSLVARAFTMRRVEALRPRIQEITD 119 Query: 155 VLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFG 214 L+ + +G+ + + VI + L Sbjct: 120 GLLDEM---LPRGRADLVDSFAYPLPITVIC-----------------------ELLGVP 153 Query: 215 FLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQL 274 +D + + + P ++ + + +L + ++ + + D D L Sbjct: 154 DIDRVTFRALSNEIVAPTGGDAELAAYER-LAAYLDELIDDKRSTAPAD------DLLGD 206 Query: 275 MIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKE 334 +I ++ E LS EL A + I + AG+ETT ++++ ++ L THPD L+ + Sbjct: 207 LIRTR----AEDDDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRAD 262 Query: 335 IDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF-PVAIRLERTCKKDVEINGVFIPKGSM 393 M LD V E LR PV R + +EI G I +G Sbjct: 263 ------------------MTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDP 304 Query: 394 VVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKL 453 V+I A DP +P F R P + FG G C+G A + ++ Sbjct: 305 VMIGLDAAGRDPARHPDPHVFDIHR--------APQGHLAFGHGIHYCLGAPLARLEARV 356 Query: 454 ALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKV 492 AL +L+ P L++ + + ++ Sbjct: 357 ALRSLLERCPDLALDGP--PGARPPGMLIRGVRRLPVRW 393 >2VZM-A nrPDB Length = 436 Score = 235 bits (598), Expect = 5e-62, Method: Composition-based stats. Identities = 83/477 (17%), Positives = 162/477 (33%), Gaps = 69/477 (14%) Query: 24 LYGTRTHGLFKRLGIPGPTPLPLLGNVLS-YRQGLWKFDTECYKKYGKMWGTYE-GQLPV 81 L +H + G P+ LG + + + + G V Sbjct: 14 LVPRGSHMRRTQQGTTASPPVLDLGALGQDFAADPYPTYARLRAE-GPAHRVRTPEGNEV 72 Query: 82 LAITDPDVIRTVLVKECYSVF---TNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFT 138 + D R VL +S + + + ++ R+R L++ FT Sbjct: 73 WLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFT 132 Query: 139 SGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNN 198 +++ + P + + D LV + A G+ ++ + + VI GV Sbjct: 133 MRRVELLRPRVQEIVDGLVDAML-AAPDGRADLMESLAWPLPITVI-SELLGVP----EP 186 Query: 199 PQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKK 258 + F T F+ + + +LS+ ++ + Sbjct: 187 DRAAFRVWTDAFVFPD-------------------DPAQAQTAMAEMSGYLSRLIDSKRG 227 Query: 259 SRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTL 318 + D L ++ + + E L+ EL + I + AG+ETT ++++ + Sbjct: 228 -------QDGEDLLSALVRTSD----EDGSRLTSEELLGMAHILLVAGHETTVNLIANGM 276 Query: 319 YELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF-PVAIRLERTC 377 Y L +HPD L+ + M LD V E LR PV R Sbjct: 277 YALLSHPDQLAALRAD------------------MTLLDGAVEEMLRYEGPVESATYRFP 318 Query: 378 KKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTG 437 + V+++G IP G V++ H P+ + +P F R + + FG G Sbjct: 319 VEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAG--------HLAFGHG 370 Query: 438 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDS 494 CIG A + ++A+ +L+ + L +++ K + ++ Sbjct: 371 IHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWRR 427 >2VE3-A nrPDB Length = 444 Score = 234 bits (596), Expect = 8e-62, Method: Composition-based stats. Identities = 96/438 (21%), Positives = 175/438 (39%), Gaps = 30/438 (6%) Query: 39 PGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKEC 98 PG LP LG L++ F + +++G ++ T V+ I+ R + KE Sbjct: 15 PGDFGLPWLGETLNFLND-GDFGKKRQQQFGPIFKTRLFGKNVIFISGALANRFLFTKEQ 73 Query: 99 YSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVR 158 + + +A++ E + R +L F L P + + Sbjct: 74 ETFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLDSYLPKMDGIVQGYLE 133 Query: 159 NLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDP 218 + E V + DV G + F + + Sbjct: 134 QWGKANE----VIWYPQLRRMTFDVAATLFMGEKVSQNPQL-------------FPWFET 176 Query: 219 LFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDS 278 + P P + L K + ++ +++ D L +++ + Sbjct: 177 YIQGLFSLPIPLPNTLFGKSQRARALLLAELEKIIKARQQQPPSEE-----DALGILLAA 231 Query: 279 QNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAV 338 ++ ++++ LS EL Q ++ +FAG+ET +S LS L H D+++++++E + + Sbjct: 232 RD----DNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKL 287 Query: 339 LPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPT 398 ++ T + + +M YLD V+ E LRL P R +D + G PKG +V Sbjct: 288 QLSQ-ELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHFPKGWLVSYQI 346 Query: 399 YALHHDPKYWTEPEEFRPERFSKKKDSI--DPYIYTPFGTGPRNCIGMRFALMNMKLALI 456 H DP + +PE+F PERF+ + P+ + PFG G R C+G FA + MKL Sbjct: 347 SQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFAT 406 Query: 457 RVLQNFSFKPCKETQIPL 474 R++Q F + + L Sbjct: 407 RLIQQFDWTLLPGQNLEL 424 >6CR2-A nrPDB Length = 477 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 94/481 (19%), Positives = 174/481 (36%), Gaps = 50/481 (10%) Query: 44 LPLLGNVLSYRQGLWKFDTECYKKYGKMWG-TYEGQLPVLAIT--DPDVI-----RTVLV 95 P +G+ +SY +KF +C KYG ++ G+ + + D I R V Sbjct: 13 FPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFILNGKLRDVCA 72 Query: 96 KECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDV 155 +E YS T PV F + + + + + + TS L+ P+I + Sbjct: 73 EEVYSPLTT-----PV-FGRHVVYDCPNAKLMEQKKFVKYGLTSDALRSYVPLITDEVES 126 Query: 156 LVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGF 215 V+N + + I S + + + D L GF Sbjct: 127 FVKNSPAFQGHKGVFDVCKTIAEIT---IYTASRSLQGKEVRSKFDSTFAELYHNLDMGF 183 Query: 216 LDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLM 275 F+ P+ + + + +++ + M Sbjct: 184 APINFMLP-----WAPLPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSED-------M 231 Query: 276 IDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEI 335 + + S ++ + D E+A I + AG ++SS S+ + LAT PD+ ++L +E Sbjct: 232 VWNLMSCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQ 291 Query: 336 DAVLPNKAPP-TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEING--VFIPKGS 392 VL + PP TYD + +++ V+ ETLRL + R K + ++G IP Sbjct: 292 IRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSH 351 Query: 393 MVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI-----------------DPYIYTPFG 435 V+ +++ P E+ P R+ + + Y PFG Sbjct: 352 NVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFG 411 Query: 436 TGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ-IPLKLDTQGLLQPEKPIVLKVDS 494 G CIG +FA + + +++ F F+ IP + +P ++ + Sbjct: 412 AGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVDGIPDTDYSSLFSKPLGRSFVEFEK 471 Query: 495 R 495 R Sbjct: 472 R 472 >3WVS-A nrPDB Length = 401 Score = 229 bits (583), Expect = 3e-60, Method: Composition-based stats. Identities = 75/443 (16%), Positives = 158/443 (35%), Gaps = 73/443 (16%) Query: 57 LWKFDTECYKKYGKMWGTYE-GQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVG--- 112 L + T G + P T + R VL +S + P Sbjct: 25 LSESYTRARDTDG-LIRVKLPYGEPAWLATRYEDARLVLGDARFSRALSEEHDPPRARKF 83 Query: 113 -FMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT 171 ++ + + R+R L+S FT +++E+ P + L+ ++ KG+P Sbjct: 84 NAQAKSMFNMDAPDHTRLRRLISKAFTIRRVEELRPKVHDLAHRLIDDM---LAKGEPAD 140 Query: 172 LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTP 231 L + + GV + ++ F T L L+P + Sbjct: 141 LVADYALPIPTTVICELLGVPFE----DREKFGRWTDAILSTSTLNPEEGRVKRM----- 191 Query: 232 VFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALS 291 + + ++ + + + D + MI++++ ++ L+ Sbjct: 192 ------------ELVGYIGGIIAARRA-------QPADDLISGMIEARDVQDK-----LT 227 Query: 292 DLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVV 351 + EL I + AG+ETT+S + +Y L P ++L + Sbjct: 228 EQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWKRLLDD----------------- 270 Query: 352 QMEYLDMVVNETLRLFPVAIR--LERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 E + V E R P+ R ++D+E+ G + G V++ A + D + Sbjct: 271 -PELIPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFE 329 Query: 410 EPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKE 469 +PEE + +R S + FG G +C+G A + ++ AL +L+ P + Sbjct: 330 DPEEIKLDRPSNH--------HIGFGHGIHHCLGAPLARLELQEALRALLERL---PTLK 378 Query: 470 TQIPLKLDTQGLLQPEKPIVLKV 492 + ++ +++ + + + Sbjct: 379 VAGDIAWKSEMMVRGPRSMPVGW 401 >4GGV-A nrPDB Length = 418 Score = 229 bits (583), Expect = 3e-60, Method: Composition-based stats. Identities = 77/416 (18%), Positives = 147/416 (35%), Gaps = 66/416 (15%) Query: 71 MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGF----MKSAISLAEDEEW 126 +W Y + + D D ++ L PV ++ +S + Sbjct: 55 VWNVYGYPEAMDILNDHDTF-----------TSDLAHLLPVSVDAPLLEGDMSQMDPPRH 103 Query: 127 KRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITG 186 ++ R L+S FT + +M +A L+ + + E + + ++ Sbjct: 104 RKYRQLVSRAFTPRLVADMETRVADITRELLDAVDGKPE----IEIAADLAYPLPVIVIA 159 Query: 187 TSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTI 246 GV + L + D + F FL + +D Sbjct: 160 ELLGVPAGDRD-------------LFKKWADDIIEGFSGFSFLDTSGQG---EQDVRDAT 203 Query: 247 NFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAG 306 L ++ M ++ R D L ++ ++ E L+D E+ + I + G Sbjct: 204 ERLRPLLDYMAGHVTERRRTPREDLLTHLVQAEVDGER-----LTDNEIVNVANILLVTG 258 Query: 307 YETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL 366 + TT+ L T+ L P+V K++ + + + E LR+ Sbjct: 259 HITTTMTLGNTVLCLDADPEVAAKVRADRS------------------LVPGAIEEALRV 300 Query: 367 FPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI 426 + L R ++VE+ G IPK +V++ A + DP+ +T+PE + P R Sbjct: 301 LSPSAALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTR-------- 352 Query: 427 DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLL 482 DP + FG G C+G A + ++AL + F + P T ++ Sbjct: 353 DPNPHFGFGRGIHFCLGAPLARLEGRVALNALFDRFPVLRTDPAKPPTFFPTPDMI 408 >4XE3-A nrPDB Length = 407 Score = 227 bits (578), Expect = 1e-59, Method: Composition-based stats. Identities = 79/464 (17%), Positives = 157/464 (33%), Gaps = 74/464 (15%) Query: 40 GPTP---LPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYE--GQLPVLAITDPDVIRTVL 94 GPTP +P L + L E + + G+ +T R VL Sbjct: 7 GPTPADAVPAYPFSLPHALDLDPHYAELRRDE-PVSRVRLPYGEGTAWLVTRMSDARIVL 65 Query: 95 VKECYSVFTNRRSLGPVGF----MKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIA 150 +S P F + + + R+R L+ FT+ +++EM P + Sbjct: 66 GDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFTARRVEEMRPRVR 125 Query: 151 QYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKF 210 D L+ ++ G P L + + GV ++ + Sbjct: 126 SLVDSLLDDM---VAHGSPADLVEFLAVPFPVAVICELLGVPLEDRD------------- 169 Query: 211 LKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLD 270 L F D + S L A + +D + ++ V + + + D Sbjct: 170 LFRTFSDAMLSSTRLT--------AAEIQRVQQDFMVYMDGLVAQRRDAPTE-------D 214 Query: 271 FLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQK 330 L + + T++ L+ E+ + + AG+ET+ + ++ ++ L T + Sbjct: 215 LLGALALA-----TDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTERKRYES 269 Query: 331 LQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIR--LERTCKKDVEINGVFI 388 L + + V E LR P+ R +DVE++ V + Sbjct: 270 LVAD------------------PALVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTV 311 Query: 389 PKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFAL 448 G V+ + + D + + +E R + + FG G +CIG + Sbjct: 312 RAGEPCVVHFASANRDEEVFDHADELDFHR--------ERNPHIAFGHGAHHCIGAQLGR 363 Query: 449 MNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKV 492 + ++ AL +++ F E LK L++ + ++ Sbjct: 364 LELQEALSALVRRFPTLDLAEPVAGLKWKQGMLIRGLERQIVSW 407 >3L4D-A nrPDB Length = 453 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 90/455 (19%), Positives = 168/455 (36%), Gaps = 44/455 (9%) Query: 45 PLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTN 104 P +G+++ + + F + KKYG ++ + + D V + FT Sbjct: 13 PFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITVVGD--------VHQHSKFFTP 64 Query: 105 RRS----------LGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGD 154 R + PV F + A + + L+ T K + P I Sbjct: 65 RNEILSPREVYSFMVPV-FGEGVAYAAPYPRMREQLNFLAEELTVAKFQNFAPSIQHEVR 123 Query: 155 VLVRNLRREAEKGK-PVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKF 213 ++ K + + + D A ++ FG ++ + + F + K Sbjct: 124 KF---MKANWNKDEGEINILDDCSAMIINTACQCLFGEDLRKRLDARQ-FAQLLAKMESC 179 Query: 214 GFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQ 273 +FL IL L + + + + LS+ + +K K + D L Sbjct: 180 LIPAAVFLPWILKLPLPQSYRCRDA---RAELQDILSEIIIAREKEEAQ-KDTNTSDLLA 235 Query: 274 LMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELA--THPDVQQKL 331 ++ + +S E+ + +FAG T++ +++L L + KL Sbjct: 236 GLLGAV----YRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKL 291 Query: 332 QKEIDAVLPNKAPPTYDAV-VQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPK 390 +EID A YD V +M + + E++R P + L R K V++ +P+ Sbjct: 292 HQEIDEF---PAQLNYDNVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPE 348 Query: 391 GSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMN 450 G ++ H D + + P E+ PER K D + FG G CIG +F L+ Sbjct: 349 GDIIACSPLLSHQDEEAFPNPREWNPERNMKLVDG----AFCGFGAGVHKCIGEKFGLLQ 404 Query: 451 MKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPE 485 +K L VL+++ F+ P ++ P Sbjct: 405 VKTVLATVLRDYDFELLGPLPEP--NYHTMVVGPT 437 >4Z5P-A nrPDB Length = 400 Score = 225 bits (573), Expect = 4e-59, Method: Composition-based stats. Identities = 74/415 (17%), Positives = 144/415 (34%), Gaps = 67/415 (16%) Query: 83 AITDPDVIRTVLVKECYS---VFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTS 139 +T D +R +S + + P+ I + E R+R LLS FT+ Sbjct: 48 MVTRYDDVRAANSDPRFSRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSKAFTA 107 Query: 140 GKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNP 199 ++ M + + L+ + R G P + + GV + Sbjct: 108 RRMGAMQSWLEELFAGLLDGVERT---GHPADIVRDLAQPFTIAVICRLLGVPYEDRG-- 162 Query: 200 QDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKS 259 +F + +S + +L+ V+ + + Sbjct: 163 ------------RFQHWSEVIMSTT-------AYSKEEAVSADASIRAYLADLVSARRAA 203 Query: 260 RLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLY 319 D L +++ +++ L++ EL + + AG+ET++ L +Y Sbjct: 204 -------PHDDLLGVLVSARDDD-----DRLTEDELITFGVTLLVAGHETSAHQLGNMVY 251 Query: 320 ELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA--IRLERTC 377 L TH D L++ Q E L V E LR P+ + R Sbjct: 252 ALLTHEDQLSLLRE------------------QPELLPRAVEELLRFVPLGNGVGNARIA 293 Query: 378 KKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTG 437 +DVE++G + G VV + DP+ + +P+ R + + FG G Sbjct: 294 LEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITR--------EKNPHLAFGHG 345 Query: 438 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKV 492 C+G + A M +++A+ +L+ F ++ T GL + + + + Sbjct: 346 AHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGPQRLPIAW 400 >5EX6-C nrPDB Length = 434 Score = 223 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 76/452 (16%), Positives = 142/452 (31%), Gaps = 89/452 (19%) Query: 49 NVLSYRQGLWKFDTECYKKYGKMWGTYEGQ----LPVLAITDPDVIRTVLVKECY----- 99 + L + G++ G T DV+R VL Sbjct: 46 HTLRQGFDPADEL----RAAGELTRVRLGSGADAEHTWLATGHDVVRQVLGDHTRFSTRR 101 Query: 100 -----SVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGD 154 + P + + + + E R+R LL+P FT K++ M P I Q Sbjct: 102 RFDRNDEIGGKGVFRPRELVGNLM-DYDPPEHTRLRRLLAPGFTHRKIRRMAPYIEQIVT 160 Query: 155 VLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFG 214 + + RE G P L ++F + GV D Sbjct: 161 ERLDEMERE---GSPADLIELFADEVPGPVLCELLGVPRD-------------------- 197 Query: 215 FLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQL 274 FL L+ SL + ++ +R + + ++K D L Sbjct: 198 ---------DRAMFLQLCHRHLDASLSGRRRAAA-GEAFSRYLVTMVARERKDPGDGLIG 247 Query: 275 MIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKE 334 M+ +++ ++D EL + + AG + S ++ + L +P+ L+ + Sbjct: 248 MVVAEH------GDTVTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALRGD 301 Query: 335 IDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIR-LERTCKKDVEINGVFIPKGSM 393 + + V+E +R V RT +D + I G Sbjct: 302 V------------------PAAERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGET 343 Query: 394 VVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKL 453 V+ + DP + + R + + FG G +C+G A + +++ Sbjct: 344 VLCSLPTANRDPALLPDADRLDVTR--------EAVPHVAFGHGVHHCLGAALARLELRI 395 Query: 454 ALIRVLQNFS----FKPCKETQIPLKLDTQGL 481 A + + F P T+ L G+ Sbjct: 396 AYTALWRRFPDLRLADPDGATEFRLSTPAYGI 427 >4YZR-A nrPDB Length = 405 Score = 222 bits (566), Expect = 3e-58, Method: Composition-based stats. Identities = 62/354 (17%), Positives = 127/354 (35%), Gaps = 64/354 (18%) Query: 111 VGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPV 170 + F+ + + + R+RSL+ FT ++ + I Q + L+ + +E Sbjct: 84 IDFVSDHMLAKDTPDHTRLRSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKE----NKA 139 Query: 171 TLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLT 230 + F + ++ G+ + + F T + + + L Sbjct: 140 DIMKSFASPLPFIVISELMGIPKE----DRSQFQIWTNAMVDTSEGNRELTNQAL----- 190 Query: 231 PVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKAL 290 ++ ++++K + + + K + D + ++ ++ E+ L Sbjct: 191 ------------REFKDYIAKLI-------HDRRIKPKDDLISKLVHAE-----ENGSKL 226 Query: 291 SDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAV 350 S+ EL + + + AG ETT ++L L H +KL++ Sbjct: 227 SEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQ----------------- 269 Query: 351 VQMEYLDMVVNETLRLFPVAIRLE-RTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 Q E + V E LR + + R +D G I +G M+ I + + DP ++ Sbjct: 270 -QPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFE 328 Query: 410 EPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 PE R P + FG G C+G A + +A +L+ F Sbjct: 329 NPEILNINR--------SPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFP 374 >2X2N-A nrPDB Length = 475 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 81/454 (17%), Positives = 170/454 (37%), Gaps = 33/454 (7%) Query: 41 PTPLPLLGNVLSYRQGLWKFDTECYKKYGK-MWGTYEGQLPVLAITDP-DVIRTVLVKEC 98 P +P+LG+++ + + F EC ++ ++ V + DP + R L + Sbjct: 22 PVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFFLPRN- 80 Query: 99 YSVFTNRRS---LGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDV 155 V + R + PV F + A + + L+ T K + P I Sbjct: 81 -EVLSPREVYSFMVPV-FGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRK 138 Query: 156 -LVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFG 214 + N ++ + + L + ++ FG ++ + + + L Sbjct: 139 FMAANWDKDEGE---INLLEDCSTMIINTACQCLFGEDLRKRLDARR-----FAQLLAKM 190 Query: 215 FLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQL 274 + ++ L L + + + + +K+ +K D L Sbjct: 191 ESSLIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKAAAVNKDSSTSDLLSG 250 Query: 275 MIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHP---DVQQKL 331 ++ + +S E+ + +FAG T+S ++++ L HP + L Sbjct: 251 LLSAV----YRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLM-HPANVKHLEAL 305 Query: 332 QKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKG 391 +KEI+ +M + + E++R P + L R DV++ +PKG Sbjct: 306 RKEIEEFPAQLNYNNVMD--EMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKG 363 Query: 392 SMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNM 451 ++ HHD + + EP + PER K + + + FG G CIG +F L+ + Sbjct: 364 DIIACSPLLSHHDEEAFPEPRRWDPERDEKVEGA-----FIGFGAGVHKCIGQKFGLLQV 418 Query: 452 KLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPE 485 K L +++ F+ ++ ++P ++ P Sbjct: 419 KTILATAFRSYDFQLLRD-EVPDPDYHTMVVGPT 451 >1EHE-A nrPDB Length = 403 Score = 221 bits (563), Expect = 5e-58, Method: Composition-based stats. Identities = 63/387 (16%), Positives = 122/387 (31%), Gaps = 61/387 (15%) Query: 78 QLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTF 137 V + + + V ++ + + K + E RS++ PTF Sbjct: 48 HKDVCFVATSEKLSKVRTRQGFPELSASGKQA--AKAKPTFVDMDPPEHMHQRSMVEPTF 105 Query: 138 TSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLN 197 T +K + P I + D L+ ++++ PV L F I T GV + L Sbjct: 106 TPEAVKNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALPVPSYIIYTLLGVPFNDL- 164 Query: 198 NPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMK 257 ++ G S ++ +++L+ V + Sbjct: 165 ----EYLTQQNAIRTNGSSTAR-----------------EASAANQELLDYLAILVEQR- 202 Query: 258 KSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFT 317 + + D + + Q + + + + + AG T ++++ Sbjct: 203 ------LVEPKDDIISKLCTEQVKP-----GNIDKSDAVQIAFLLLVAGNATMVNMIALG 251 Query: 318 LYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPV-AIRLERT 376 + LA HPD +L+ V E R A+ ++RT Sbjct: 252 VATLAQHPDQLAQLKA------------------NPSLAPQFVEELCRYHTASALAIKRT 293 Query: 377 CKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGT 436 K+DV I + ++ + + D + + P+EF R +D FG Sbjct: 294 AKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKWPPQDP------LGFGF 347 Query: 437 GPRNCIGMRFALMNMKLALIRVLQNFS 463 G CI A + + Q F Sbjct: 348 GDHRCIAEHLAKAELTTVFSTLYQKFP 374 >2WM5-A nrPDB Length = 435 Score = 221 bits (563), Expect = 5e-58, Method: Composition-based stats. Identities = 66/400 (16%), Positives = 140/400 (35%), Gaps = 66/400 (16%) Query: 83 AITDPDVIRTVLVKECYSVFTNRRSL------GPVGFMKSAISLAEDEEWKRIRSLLSPT 136 A+T D + +F++ ++ + ++ + +D +R+RS++S Sbjct: 78 ALTKYDDV--FYASRHPDIFSSYPNITINDQTPELAEYFGSMIVLDDPRHQRLRSIVSRA 135 Query: 137 FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSL 196 FT + + + LV ++ + + ++ G + +I G+ Sbjct: 136 FTPKVVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDM-MGIP---- 190 Query: 197 NNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRM 256 T L FG P L F+ +S + Sbjct: 191 KADHQRIFHWTNVILGFGD-----------PDLATDFDEFMQ----------VSADIGAY 229 Query: 257 KKSRLNDKQ-KHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLS 315 + D++ H D +++++ E LS E+A+ I+ + AG ETT + ++ Sbjct: 230 ATALAEDRRVNHHDDLTSSLVEAEVDGER-----LSSREIASFFILLVVAGNETTRNAIT 284 Query: 316 FTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLER 375 + L+ +P+ + + + D + P V E +R + + R Sbjct: 285 HGVLALSRYPEQRDRWWSDFDGLAPT-----------------AVEEIVRWASPVVYMRR 327 Query: 376 TCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPF- 434 T +D+E+ G + G V + + + D + +P F R +P + F Sbjct: 328 TLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLAR--------NPNPHLGFG 379 Query: 435 GTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPL 474 G G C+G A +++A + + E L Sbjct: 380 GGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARL 419 >4JBT-A nrPDB Length = 410 Score = 221 bits (562), Expect = 8e-58, Method: Composition-based stats. Identities = 98/454 (21%), Positives = 163/454 (35%), Gaps = 98/454 (21%) Query: 28 RTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYG--KMW--GTYEGQLPVLA 83 R G R+ + G L + G+ L+ + DT K +W GT Q P++ Sbjct: 27 RAAGPLTRIDLLGVPALAVTGHTLARQ---LLTDTRLVKDINAWSLWQSGTVTRQWPLIG 83 Query: 84 ITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLK 143 + D D S+FT + E +R+R + T +L Sbjct: 84 MIDVD----------RSMFT-----------------VDGPEHRRLRIKTTQALTRRRLD 116 Query: 144 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF 203 + P I +Y L+ +L R G V LK +F + GV + Q+ Sbjct: 117 ALKPTIERYVAELLDDLERAGADGAVVDLKSVFAYPLPMRVISALMGVP----SEDQEQL 172 Query: 204 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND 263 + K F F LTP E L V D ++ + R K + D Sbjct: 173 LTWYKAF---------------FSILTPQDERLRVI----DEMHGYFTEMVRRKTAEPGD 213 Query: 264 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT 323 D +I + T+ L++ E+ + AG+ETT S++ + L + Sbjct: 214 ------DLTSALIYA-----TDGETPLTEEEVIGNLQALVAAGHETTVSLILTAVRALLS 262 Query: 324 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF-PVAIRLERTCKKDVE 382 HP+ + ++ D + + + ETLR PV L R +D++ Sbjct: 263 HPEQLRLVR---DGEIG---------------WETAIEETLRWDGPVIHLLMRFATEDID 304 Query: 383 INGVFIPKGSMVVIPTYALHHDPKYW-TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNC 441 + IP+G VV+ A+ D + ++F R + + + FG GP C Sbjct: 305 LGDAVIPRGEGVVMSYRAIGRDITVHGADADDFDITRATAAR-------HISFGHGPHIC 357 Query: 442 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK 475 G A + +AL + F P +PL Sbjct: 358 PGAALARLEAAIALPALFTRF---PHLHPALPLD 388 >4UBS-A nrPDB Length = 393 Score = 220 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 83/422 (19%), Positives = 142/422 (33%), Gaps = 77/422 (18%) Query: 78 QLPVLAITDPDVIRTVLVKECYSVF-------TNRRSLGPVGFMKSAISLAEDEEWKRIR 130 V +T R +L + S V + A+ +D E + R Sbjct: 36 GRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGVDDPEHRTQR 95 Query: 131 SLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFG 190 +L P+FT + + P I + D L+ + +G P L F ++ G Sbjct: 96 RMLVPSFTLKRAAALRPRIQETVDGLLDAME---AQGPPAELVSAFALPLPSMVICALLG 152 Query: 191 VNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLS 250 V F ES + L G V ++L Sbjct: 153 VPY-----ADHDFFESQSRRLLRGPGIA------------------EVQDARAQLDDYLY 189 Query: 251 KSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETT 310 ++R +K + L +I E + + EL + + + + AG+ETT Sbjct: 190 ALIDRKRK-------EPGDGLLDDLIQ-----EQLNRGTVDRAELVSLATLLLIAGHETT 237 Query: 311 SSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA 370 ++++S + L HP+ +L+ E + V E LR +A Sbjct: 238 ANMISLGTFTLLRHPEQLAELRAE------------------PGLMPAAVEELLRFLSIA 279 Query: 371 IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI 430 L R +D+E+ G I VV T ++ D + EP+ R ++ Sbjct: 280 DGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHRSARH-------- 331 Query: 431 YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS----FKPCKETQIPLKLDTQGLLQPEK 486 + FG G C+G A M++AL + + P E QG+L E Sbjct: 332 HVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADEIPFKPGDTIQGML--EL 389 Query: 487 PI 488 P+ Sbjct: 390 PV 391 >5NWS-A nrPDB Length = 435 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 74/443 (16%), Positives = 155/443 (34%), Gaps = 84/443 (18%) Query: 56 GLWKFDTECYKKYGKMWGTYE-GQLPVLAITDPDVIRTVLVKECY----SVFTNRRSLGP 110 + ++ G + PV +T D +R VL + S P Sbjct: 35 DPFTGYGRLRER-GPVVRGRFVDGTPVWFVTRYDDVRAVLRDPRFVNTPSPVPGEGGADP 93 Query: 111 VG--------------FMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVL 156 ++ +I ++ + R+R L++ F + ++ + P I + D L Sbjct: 94 REGMMDLLNVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRILGLRPGIERIADRL 153 Query: 157 VRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQD---PFVESTKKFLKF 213 + L R E+ V L + F + G+ L ++ V + L+ Sbjct: 154 LAELPRREEEDGTVDLLEHFAYPLSITVICELVGIPATDLERWREWGGDLVSMRPERLRH 213 Query: 214 GFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQ 273 F I++ + + + + + + D L Sbjct: 214 SFPV---------------------------MIDYCHRLIEQRRAALTD-------DLLS 239 Query: 274 LMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQK 333 +I +Q+ + LSD+E + + AG+ET++ ++ L THP L+K Sbjct: 240 ELIRAQD----DDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALLRK 295 Query: 334 EIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF-PVAIRLERTCKKDVEINGVFIPKGS 392 + L V+E +R V + R +D+E+ G + +G Sbjct: 296 D------------------PALLPRAVHELMRWCGSVHVARLRYATEDLELAGTPVARGD 337 Query: 393 MVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMK 452 V + + + DP+++++P+ R + + + FG G C+G A + Sbjct: 338 AVQLVLVSANFDPRHYSDPDRLDITRHQEGQAE----NHVGFGHGIHYCLGATLARQEGE 393 Query: 453 LALIRVLQNFSFKPCKETQIPLK 475 +AL R+L+ + + ++ Sbjct: 394 VALARLLETYPDLALADGDPEVR 416 >3ABB-A nrPDB Length = 408 Score = 217 bits (553), Expect = 8e-57, Method: Composition-based stats. Identities = 83/425 (19%), Positives = 142/425 (33%), Gaps = 77/425 (18%) Query: 76 EGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFM---KSAISL----AEDEEWKR 128 P IT R +LV S V + ++ +D R Sbjct: 45 FDGRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGLAFPLIGVDDPVHAR 104 Query: 129 IRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTS 188 R +L P+F ++ + P + D L+ ++ KG L F V Sbjct: 105 QRRMLIPSFGVKRMNAIRPRLQSLVDRLLDDM---LAKGPGADLVSAFALPVPSVAICEL 161 Query: 189 FGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINF 248 GV D F E ++ F+ + + + Sbjct: 162 LGVPY----GDHDFFEECSRNFVGAATSAEADAAFG-------------------ELYTY 198 Query: 249 LSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYE 308 L V R + D L + ++ +E + L E+ +++ + AG+E Sbjct: 199 LHGLVGRKQAE--------PEDGLLDELIARQLEEGD----LDHDEVVMIALVLLVAGHE 246 Query: 309 TTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP 368 TT + ++ L HP+ L ++ AV VV E LR Sbjct: 247 TTVNAIALGALTLIQHPEQIDVLLRDPGAVSG------------------VVEELLRFTS 288 Query: 369 VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDP 428 V+ + R K+D+E+ G I G V++ ++ D K + P+ F R ++ Sbjct: 289 VSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARRNARH------ 342 Query: 429 YIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS----FKPCKETQIPLKLDTQGLLQP 484 + FG G C+G A +++AL + P E I D QG + Sbjct: 343 --HVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLAVPLDEVPIKAGHDAQGPI-- 398 Query: 485 EKPIV 489 E P+V Sbjct: 399 ELPVV 403 >3R9C-A nrPDB Length = 418 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 70/390 (17%), Positives = 131/390 (33%), Gaps = 58/390 (14%) Query: 96 KECYSVFTNRRSLGPVGFMKSA---ISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQY 152 S R+ + + R+R L+S F +K + P I Sbjct: 72 DRTKSTIFQRQLAAETQPRPQGPASFLFLDPPDHTRLRGLVSKAFAPRVIKRLEPEITAL 131 Query: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212 D L+ + G L D + GV I+ + P+ + Sbjct: 132 VDQLLDAVD-----GPEFNLIDNLAYPLPVAVICRLLGVPIE--DEPKFSRASALLAAAL 184 Query: 213 FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFL 272 FL + LF E + ++ +D +L ++ +++ D + Sbjct: 185 DPFLALTGETSDLFD------EQMKAGMWLRD---YLRALIDERRRT-------PGEDLM 228 Query: 273 QLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQ 332 ++ + ES L++ E+ A + + AG+ETT ++++ + P L Sbjct: 229 SGLVAVE-----ESGDQLTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWAALA 283 Query: 333 KEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGS 392 + V+ ET+R P + R D+ I +PKG Sbjct: 284 ADGSRA------------------SAVIEETMRYDPPVQLVSRYAGDDLTIGTHTVPKGD 325 Query: 393 MVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMK 452 +++ A H DP P+ F P+R + + FG G C+G A + Sbjct: 326 TMLLLLAAAHRDPTIVGAPDRFDPDRAQIR--------HLGFGKGAHFCLGAPLARLEAT 377 Query: 453 LALIRVLQNFS-FKPCKETQIPLKLDTQGL 481 +AL + F + E + L +G+ Sbjct: 378 VALPALAARFPEARLSGEPEYKRNLTLRGM 407 >4OQS-A nrPDB Length = 433 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 84/424 (19%), Positives = 140/424 (33%), Gaps = 83/424 (19%) Query: 84 ITDPDVIRTVLVKECYS--------VFTN--RRSLGPVGFMKSAISLAEDEEWKRIRSLL 133 +T RTV++ +S VF+ R + E R R +L Sbjct: 50 VTSHAAARTVMIDPRFSNRPEHKHPVFSVIPRPGGATKAPAPGWFINMDAPEHTRYRRML 109 Query: 134 SPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNI 193 FT ++KE+ P I Q + +L A+ G PV L F ++ GV+ Sbjct: 110 ISQFTVRRIKELEPRIVQITE---DHLDAMAKAGPPVDLVQAFALPVPSLVICELLGVSY 166 Query: 194 DSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSV 253 Q+ V + L K Sbjct: 167 ADHAFFQEQTTIMAS-----------------------------VDKTQDEVTTALGKLT 197 Query: 254 NRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSV 313 + + + + D L +I L+D EL +++ + AG+ETT+++ Sbjct: 198 RYIAELVATKRLSPKDDLLGSLIT---------DTDLTDEELTNIALLLLVAGHETTANM 248 Query: 314 LSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI-- 371 L + L HP+ L V E LR + Sbjct: 249 LGLGTFALLQHPEQIAALDS-----------------------PDAVEELLRYLSIVHLG 285 Query: 372 RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY 431 R +DVE+ G I KG V I A++ DPK + EP+ + +R +K + Sbjct: 286 TPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRVDARK-------H 338 Query: 432 TPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLK 491 FG G C+G + A + M++ R+ F +KL + + + Sbjct: 339 AAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLREKSAAYGVWALPVA 398 Query: 492 VDSR 495 D+R Sbjct: 399 WDAR 402 >6CVC-A nrPDB Length = 433 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 71/399 (17%), Positives = 137/399 (34%), Gaps = 64/399 (16%) Query: 83 AITDPDVIRTVLVKECYSVFTNRRSL------GPVGFMKSAISLAEDEEWKRIRSLLSPT 136 A+T D I +F + ++ + ++ + +D +R+RS++S Sbjct: 75 ALTKHDDIH--FASRHPEIFHSSPNIVIHDQTPELAEYFGSMIVLDDPRHQRLRSIVSRA 132 Query: 137 FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSL 196 FT + + + + LV + G+ + ++ G + +I G+ + Sbjct: 133 FTPKVVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDM-MGIPEEDH 191 Query: 197 NNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRM 256 T L FG D T E L VS+ L+ Sbjct: 192 EQIFH----WTNVILGFGDPD----------LTTDFDEFLQVSMAIGGYATALAD----- 232 Query: 257 KKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSF 316 + + H D +++++ E LS E+A I+ + AG ETT + +S Sbjct: 233 -----DRRVNHHGDLTTSLVEAEVDGER-----LSSSEIAMFFILLVVAGNETTRNAISH 282 Query: 317 TLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERT 376 + L+ +PD + K + D V E +R + + RT Sbjct: 283 GMLALSRYPDERAKWWSDFDG-----------------LAATAVEEIVRWASPVVYMRRT 325 Query: 377 CKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPF-G 435 +DV++ G + G V + + + D + + +P F R +P F G Sbjct: 326 LSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTR--------NPNPQVGFGG 377 Query: 436 TGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPL 474 G C+G A +++ + + E L Sbjct: 378 GGAHFCLGANLARREIRVVFDELRRQMPDVVATEEPARL 416 >1Z8P-A nrPDB Length = 404 Score = 216 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 83/438 (18%), Positives = 151/438 (34%), Gaps = 76/438 (17%) Query: 70 KMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGP-------VGFMKSA----- 117 + +T D + L S ++ G +GF + Sbjct: 28 PVTPVRFLGQDAWLVTGYDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVRNYFA 87 Query: 118 --ISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDI 175 + ++ R+R L+S FT +++ M P + Q L+ + V + D Sbjct: 88 TNMGTSDPPTHTRLRKLVSQEFTVRRVEAMRPRVEQITAELLDEVGDSG----VVDIVDR 143 Query: 176 FGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEA 235 F + GV+ +FG L + A Sbjct: 144 FAHPLPIKVICELLGVDEKYRG--------------EFGRWSSEILVMDPE-------RA 182 Query: 236 LNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLEL 295 ++ +NF+ V R + + D L +I Q+ + LS EL Sbjct: 183 EQRGQAAREVVNFILDLVERRRT-------EPGDDLLSALIRVQD----DDDGRLSADEL 231 Query: 296 AAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEY 355 + +++ + AG+E++ S++ Y L THPD ++++ A Sbjct: 232 TSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVRRDPSA------------------ 273 Query: 356 LDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFR 415 L V E LR R ++VEI GV IP+ S V++ A + DPK + +P F Sbjct: 274 LPNAVEEILRYIAPPETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFD 333 Query: 416 PERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK 475 R ++ + FG G C+G A + ++AL + F + Sbjct: 334 VTRDTRG--------HLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADDVV 385 Query: 476 LDTQGLLQPEKPIVLKVD 493 LL+ + +++D Sbjct: 386 WRRSLLLRGIDHLPVRLD 403 >5IT1-A nrPDB Length = 399 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 73/425 (17%), Positives = 141/425 (33%), Gaps = 69/425 (16%) Query: 74 TYEGQLPVLAITDPDVIRTVLVKECYSV-----FTNRRSLGPVGFMKSAISLAEDEEWKR 128 T+ +T + +R VL +SV + + + ++ + E Sbjct: 38 TFTSGHEAWLVTGYEQVRAVLRDPSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEHTD 97 Query: 129 IRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTS 188 R LL+ FT +++ + P I + D + + +G PV L F ++ Sbjct: 98 DRKLLAKEFTVRRMQALRPNIQRIVDEHLDAIE---ARGGPVDLVKTFANPVPSMVISDL 154 Query: 189 FGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINF 248 FGV + + F E + ++ + + Sbjct: 155 FGVPAER----RAEFQEIAEAMMRVDQDAAATEAAGMR---------------------- 188 Query: 249 LSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYE 308 L + ++ + R + D + +I ++ + + D+ L + + A ++ Sbjct: 189 LGGLLYQLVQERRAN---PGDDLISALITTE-----DPDGVIDDMFLMNAAGTLLIAAHD 240 Query: 309 TTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP 368 TT+ ++ L PD LQK+ + V E LR Sbjct: 241 TTACMIGLGTALLLDRPDQLALLQKD------------------PSLIGNAVEELLRYLT 282 Query: 369 VAI-RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID 427 + ER +D EI GV I KG VV + DP + +PE F R Sbjct: 283 IGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITR--------R 334 Query: 428 PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKP 487 P + FG G CIG + A + +++ + + F + L+ + Sbjct: 335 PAPHLAFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKPVEELRFRNDMVFYGVHE 394 Query: 488 IVLKV 492 + + Sbjct: 395 LPVTW 399 >6GMF-A nrPDB Length = 397 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 70/395 (17%), Positives = 133/395 (33%), Gaps = 68/395 (17%) Query: 75 YEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPV-------GFMKSAISLAEDEEWK 127 +A+ + VL F+NR + M +I + Sbjct: 31 RLQPQGFMAVGRYQDVARVLHDAKG--FSNRGWAASLPRGVKWDTSMPPSIVQVDPPRHG 88 Query: 128 RIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGT 187 ++R+L++ FT + ++ P I LV LR + ++ Sbjct: 89 KLRTLVTKAFTPRTVAQLEPRIRDIAHELVDGLRGK----STFEATVEVTVPMPMIVIAE 144 Query: 188 SFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTIN 247 GV + ++ + D + S+ L A + ++ Sbjct: 145 MLGVAPE-------------RRADFKRWSDDMVGSLALVRVGN----AAQLERSTQEFYA 187 Query: 248 FLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGY 307 + S+ + +++ R D + ++ ++ E L+ E+ + + + AG Sbjct: 188 YFSEVLEER-------RREPREDLISQLLAAEVDGEK-----LTAGEVLSFANTLLIAGN 235 Query: 308 ETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF 367 ETT+S++ L L HP+ Q + + + VV E LR Sbjct: 236 ETTTSLIGNALVALTDHPEQLAAAQAD------------------LSLVPAVVEEVLRYE 277 Query: 368 PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID 427 A + R DVEI IP S+V+ + + D + +P+ F R +K Sbjct: 278 SPAQCIFRQTMTDVEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHRDTKG----- 332 Query: 428 PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 + FG CIG A + K+ L +L Sbjct: 333 ---HLAFGLDIHFCIGAPLARLEAKVMLEVLLARL 364 >5Y1I-A nrPDB Length = 403 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 74/427 (17%), Positives = 149/427 (34%), Gaps = 73/427 (17%) Query: 73 GTYEGQLPVLAITDPDVIRTVLVKECYSVFTNR-------RSLGPVGFMKSAISLAEDEE 125 ++G P + T R +L S R + + + + +D E Sbjct: 37 RIWDGSTPWVV-TRHADQRALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPE 95 Query: 126 WKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVIT 185 RIR +++ FT+ +++ M P I + D L+ + KPV L + + Sbjct: 96 HGRIRRMVTLPFTARRIEAMRPAIQKITDELIDGM---LAGPKPVDLVEALALPVPVRVI 152 Query: 186 GTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDT 245 GV + Q + G ++ Sbjct: 153 CEMLGVPYEDREFLQQNNNAMIYRDTAQGDAQKAAIA----------------------- 189 Query: 246 INFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFA 305 + + + ++L D+ L L + +++ ++ + A ++ + A Sbjct: 190 ---QAMYLKELVGTKLGDRGDDILSDLAVQVEA---------GEITQDDAAGIGMMLLGA 237 Query: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR 365 G+ETT+++++ L +P+ +++ + + V E LR Sbjct: 238 GHETTANMIALGTLALLENPEQLAEVR----------------DSDDPKVIVNTVEELLR 281 Query: 366 LFPVAI-RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTE-PEEFRPERFSKKK 423 +A + R +D+EI GV I G +V P A + DP + E P+ R + ++ Sbjct: 282 YLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHRANARR 341 Query: 424 DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET--QIPLKLDTQGL 481 + FG G C+G A + +++ +L+ T +IP K D Sbjct: 342 -------HLAFGYGVHQCLGATLARVELQIVYSTLLRRIPTLALAGTLDEIPFKHDQIAH 394 Query: 482 LQPEKPI 488 E P+ Sbjct: 395 GVYELPV 401 >5XW2-A nrPDB Length = 419 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 66/404 (16%), Positives = 147/404 (36%), Gaps = 57/404 (14%) Query: 84 ITDPDVIRTVLVKEC-YSVFTNR--RSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSG 140 + VL +S +R F + + + + + +R L+S FT Sbjct: 57 VYGYAEAIEVLGDPGTFSSHMSRLLPMGADEAFTEGDLLQTDPPDHRELRKLVSHAFTPK 116 Query: 141 KLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200 + E+ P I L+ + + D++T ++ + + + Sbjct: 117 VVAELEPRITALTQELLDAVADRD---------------TFDLMTALAYPLPVTVVAELL 161 Query: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSR 260 + S + L G++ + S+ + + + + K + +++ Sbjct: 162 S--IPSADRHLFEGWMTEIVHSLGDVSMED---APEDQERIFEAGMAPMRKMLEYLREHA 216 Query: 261 LNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYE 320 +++ R D + +I+++ + L+D + + + + AGY TT+ ++ T+ Sbjct: 217 AECRRRPRGDLMGKLIEAEVD-----GRRLTDNHIVNFAKMLLIAGYLTTTMLIGNTVLC 271 Query: 321 LATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKD 380 L ++P+ +++ + + ++ E++R R +D Sbjct: 272 LDSYPEQAARVRADRS------------------LIPGLLEESMRFLSPVAATYRATTRD 313 Query: 381 VEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRN 440 VE+ G + MV++ A + D + + EPE F R P + FG G Sbjct: 314 VEVAGQRLSADQMVMVWFGAANRDARQFAEPELFDMTR--------GPNPHLGFGRGIHF 365 Query: 441 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPL---KLDTQGL 481 C+G A M ++AL +L F + P DT G+ Sbjct: 366 CLGGPLARMEGRVALDHLLDRFPELYTDPERPPTFMPGFDTTGV 409 >4TRI-A nrPDB Length = 407 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 73/424 (17%), Positives = 152/424 (35%), Gaps = 66/424 (15%) Query: 70 KMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRI 129 ++ G + A T + +F++ + P + +D + Sbjct: 35 PVFRDRNG---LAAATTYQAVLDAERNP--ELFSSTGGIRPDQPGMPYMIDMDDPQHLLR 89 Query: 130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSF 189 R L++ FT ++ + I + D L+ + E+G+ ++DI M VI Sbjct: 90 RKLVNAGFTRKRVMDKVDSIGRLCDTLIDAV---CERGECDFVRDIAAPLPMAVI----- 141 Query: 190 GVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFL 249 G + L +D ++ + L L+ + + ++ Sbjct: 142 GDMLGVLPTERDMLLKWSD---------------DLVCGLSSHVDEAAIQ----KLMDTF 182 Query: 250 SKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYET 309 + K + + D ++++S+ + +SD E+ ++++ + G ET Sbjct: 183 AAYTEFTKDVITKRRAEPTDDLFSVLVNSEV-----EGQRMSDDEIVFETLLILIGGDET 237 Query: 310 TSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPV 369 T LS +L H D L ++D L + E LR Sbjct: 238 TRHTLSGGTEQLLRHRDQWDALVADVD------------------LLPGAIEEMLRWTSP 279 Query: 370 AIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY 429 + RT D +G + G +++ + + D + +P+ FR +R +P Sbjct: 280 VKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDR--------NPN 331 Query: 430 IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLDTQGLLQPEK-P 487 + FG G C+G + A + ++L RVL+ + + +PL+ + PE P Sbjct: 332 SHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLR-PANFVSGPESMP 390 Query: 488 IVLK 491 +V Sbjct: 391 VVFT 394 >2WIO-A nrPDB Length = 431 Score = 214 bits (544), Expect = 9e-56, Method: Composition-based stats. Identities = 77/430 (17%), Positives = 141/430 (32%), Gaps = 65/430 (15%) Query: 70 KMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMK--SAISLAEDEEWK 127 +W G + ++TVL F++ + G I + E + Sbjct: 62 PVWQDRYGVW---HVFRHADVQTVLRDTA--TFSSDPTRVIEGASPTPGMIHEIDPPEHR 116 Query: 128 RIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGT 187 +R ++S FT + ++ P I L+ A+ G+ L D+ I Sbjct: 117 ALRKVVSSAFTPRTISDLEPRIRDVTRSLL------ADAGESFDLVDVLAFPLPVTIVAE 170 Query: 188 SFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTIN 247 G+ + F + + + DP ++ + + Sbjct: 171 LLGLP----PMDHEQFGDWSGALVDIQMDDPTDPAL------------------AERIAD 208 Query: 248 FLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGY 307 L+ +K + D + ++ ++ +AL D E A S + AG+ Sbjct: 209 VLNPLTAYLKARCAERRADPGDDLISRLVLAEVD-----GRALDDEEAANFSTALLLAGH 263 Query: 308 ETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF 367 TT+ +L + L HP ++ + +V E LR Sbjct: 264 ITTTVLLGNIVRTLDEHPAHWDAAAEDPGR------------------IPAIVEEVLRYR 305 Query: 368 PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID 427 P +++RT K E+ GV IP MV + + D +P+ F P R S Sbjct: 306 PPFPQMQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSRKSGGAAQ-- 363 Query: 428 PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEK- 486 FG G C+G A + ++AL ++ F L+ Q +L Sbjct: 364 ----LSFGHGVHFCLGAPLARLENRVALEEIIARFGRLTVDRDDERLRHFEQIVLGTRHL 419 Query: 487 PIVLKVDSRD 496 P++ R Sbjct: 420 PVLAGSSPRQ 429 >4OQR-A nrPDB Length = 457 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 81/392 (20%), Positives = 134/392 (34%), Gaps = 83/392 (21%) Query: 84 ITDPDVIRTVLVKECYS--------VFTN--RRSLGPVGFMKSAISLAEDEEWKRIRSLL 133 +T RTV++ +S VF+ R + + E R R +L Sbjct: 89 VTSHAAARTVMIDPRFSNRPEHKHPVFSVIPRPGGATKAPAPGWFTNMDAPEHTRYRRML 148 Query: 134 SPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNI 193 FT ++KE+ P I + + +L A+ G PV L F ++ GV Sbjct: 149 ISQFTVRRIKELEPRIVRITE---DHLDAMAKAGPPVDLVQAFALPVPSLVICELLGV-- 203 Query: 194 DSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSV 253 + D F ++ V + L K Sbjct: 204 --------------------SYADHAFFQEQTTIMVS-------VDKTQDEVTTALGKLT 236 Query: 254 NRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSV 313 + + + + D L +I L+D EL ++I + AG+ETT+++ Sbjct: 237 RYIAELVATKRLSPKDDLLGSLIT---------DTDLTDEELTNIALILLVAGHETTANM 287 Query: 314 LSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI-- 371 L + L HP+ L V E LR + Sbjct: 288 LGLGTFALLQHPEQIANLDS-----------------------PDAVEELLRYLSIVHLG 324 Query: 372 RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY 431 R +DVE+ G I KG V I A++ DPK + EP+ + +R +K + Sbjct: 325 TPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRVDARK-------H 377 Query: 432 TPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 FG G C+G + A + M++ R+ F Sbjct: 378 AAFGGGIHQCLGQQLARVEMRIGFTRLFARFP 409 >4Z5Q-A nrPDB Length = 423 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 77/430 (17%), Positives = 147/430 (34%), Gaps = 70/430 (16%) Query: 39 PGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKEC 98 P P P G S L + + ++ + P +T D R VL Sbjct: 33 PAPVAYPFTG---SEGLELSQSYAKLFEDGDPIRVQLPFGEPAWLVTRYDDARFVLTDRR 89 Query: 99 YSVFTNRRSLGPV---GFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDV 155 +S + P + +I + + R+R+L+S FT +++ I + Sbjct: 90 FSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRTLVSKAFTPRRIESKRAWIGELAAG 149 Query: 156 LVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGF 215 LV +++ G P L + + GV D + G+ Sbjct: 150 LVADMK---AGGAPAELVGSYALAIPVTVICELLGVPED-------------DRTRLRGW 193 Query: 216 LDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLM 275 D T D + V + + R D + Sbjct: 194 CDAALS--------TGELTDEECVQSFMDLQKYFEDLVKERRA-------EPRDDLTSAL 238 Query: 276 IDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEI 335 I+++ ++H L++ EL I + G+ETT+S +S ++ L ++ +L + Sbjct: 239 IEAR-----DAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRELWTRLCAD- 292 Query: 336 DAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIR--LERTCKKDVEINGVFIPKGSM 393 E + V E LR P A R +D+ + GV + +G Sbjct: 293 -----------------PEAIPAAVEELLRFVPFAANGISPRYALEDMTVGGVLVREGEP 335 Query: 394 VVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKL 453 V++ T A++ D + +E +R + + FG G +C+G A + ++ Sbjct: 336 VIVDTSAVNRDGLVFDNADEVVIDRADNR--------HMVFGHGAHHCLGAHLARVELQE 387 Query: 454 ALIRVLQNFS 463 AL +++ Sbjct: 388 ALKALVEGMP 397 >1LG9-A nrPDB Length = 398 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 69/415 (16%), Positives = 130/415 (31%), Gaps = 89/415 (21%) Query: 83 AITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKL 142 + D T + + P + + + + E R+R L+P FT K+ Sbjct: 54 VMGDHQQFSTRRRWDPRDEIGGKGIFRPRELVGNLM-DYDPPEHTRLRRKLTPGFTLRKM 112 Query: 143 KEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDP 202 + M P I Q + + + R G P L + GV D Sbjct: 113 QRMAPYIEQIVNDRLDEMERA---GSPADLIAFVADKVPGAVLCELVGVPRD-------- 161 Query: 203 FVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLN 262 + +F K L S+++ +++ L Sbjct: 162 ----------------------------------DRDMFMKLCHGHLDASLSQKRRAALG 187 Query: 263 DKQKHRLDFLQLMIDSQNSKETES---------HKALSDLELAAQSIIFIFAGYETTSSV 313 DK +L MI + + E +D EL + + AG + S + Sbjct: 188 DKFSR---YLLAMIARERKEPGEGMIGAVVAEYGDDATDEELRGFCVQVMLAGDDNISGM 244 Query: 314 LSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIR- 372 + + + HP+ + + + V+E +R V Sbjct: 245 IGLGVLAMLRHPEQIDAFRGDEQSA------------------QRAVDELIRYLTVPYSP 286 Query: 373 LERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYT 432 R ++D+ + G I KG V+ A + DP + + R +P + Sbjct: 287 TPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTR--------EPIPHV 338 Query: 433 PFGTGPRNCIGMRFALMNMKLALIRVLQNFS----FKPCKETQIPLKLDTQGLLQ 483 FG G +C+G A + ++ + + F P ++T+ L GL + Sbjct: 339 AFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQDTEFRLTTPAYGLTE 393 >3B98-A nrPDB Length = 475 Score = 212 bits (539), Expect = 4e-55, Method: Composition-based stats. Identities = 106/520 (20%), Positives = 193/520 (37%), Gaps = 106/520 (20%) Query: 24 LYGTRTHGLFKRLGIP--GPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPV 81 LYG RT +R P +P LG+ L + + KF T +K+G ++ L + Sbjct: 9 LYGRRT----RRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYI 64 Query: 82 LAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTF---T 138 + D + VL ++ SL + + + KRI +++ P+ + Sbjct: 65 TVLLDSNCYDAVL--------SDVASLDQTSYAQVLM--------KRIFNMILPSHNPES 108 Query: 139 SGKLKEMF---PIIAQYGDVLVRNLR---REAEKGKPVTLKDIFGAYSM--DVITGTSFG 190 K EM + Q + + NLR +E G + G +++ ++ T + Sbjct: 109 EKKRAEMHFQGASLTQLSNSMQNNLRLLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGYL 168 Query: 191 VNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSII---------------LFPFLTPVFEA 235 + NN + ++F +F L P L+ +LTP Sbjct: 169 TVFGAENNNSAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTPS--- 225 Query: 236 LNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLEL 295 + P++ ++L V +++ ++ + + R LQL + N+ Sbjct: 226 -GLDRKPREQ-SWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPA----------- 272 Query: 296 AAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEY 355 F GY L THP+ + +++EI K + Sbjct: 273 -----AFWVMGY-------------LLTHPEALRAVREEIQ---GGKHLRLEERQKNTPV 311 Query: 356 LDMVVNETLRLFPVAIRLERTCKKDVEI-----NGVFIPKGSMV-VIPTYALHHDPKYWT 409 D V+ ETLRL A+ + R +D +I + +G + V P + DP+ Sbjct: 312 FDSVLWETLRLTAAAL-ITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQ 370 Query: 410 EPEEFRPERFSK----------KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVL 459 +PE F+ +RF K + Y P+GT C G FA+ +K + +L Sbjct: 371 QPEMFQFDRFLNADRTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTIL 430 Query: 460 QNFSFKPCK-ETQIPLKLDTQ---GLLQPEKPIVLKVDSR 495 F + C +PL ++ G+LQP + ++ R Sbjct: 431 TRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIR 470 >5LIE-A nrPDB Length = 414 Score = 211 bits (537), Expect = 6e-55, Method: Composition-based stats. Identities = 72/411 (17%), Positives = 132/411 (32%), Gaps = 59/411 (14%) Query: 72 WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRS 131 W + + DP +V L + +++ +D RIR Sbjct: 52 WSVATYAETLEVLRDPVTYSSV---TGGQRRFGGTVLQDLPVAGQVLNMMDDPRHTRIRR 108 Query: 132 LLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGV 191 L+S T ++ + + + L+ + E G P A + GV Sbjct: 109 LVSSGLTPRMIRRVEDDLRRRARGLLDGV----EPGAPFDFVVEIAAELPMQMICILLGV 164 Query: 192 NIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSK 251 D +L + P F + P+ + Sbjct: 165 P----------------------ETDRHWLFEAVEPGFD--FRGSRRATMPRLNVEDAGS 200 Query: 252 SVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTS 311 + + K+ D + ++ + + ++ ALSD EL + AG ETT Sbjct: 201 RLYTYALELIAGKRAEPADDMLSVVANATIDDPDA-PALSDAELYLFFHLLFSAGAETTR 259 Query: 312 SVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAI 371 + ++ L LA +PD Q L+ + E L + E +R + Sbjct: 260 NSIAGGLLALAENPDQLQTLRSD------------------FELLPTAIEEIVRWTSPSP 301 Query: 372 RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY 431 RT + V + G I G VV+ + + DP + +EF R P + Sbjct: 302 SKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITR--------KPNPH 353 Query: 432 TPFGTGPRNCIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLDTQGL 481 FG G C+G A + +++ +L F S + + + G+ Sbjct: 354 LGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEPAEWTRSNRHTGI 404 >4MM0-A nrPDB Length = 399 Score = 210 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 76/405 (18%), Positives = 145/405 (35%), Gaps = 64/405 (15%) Query: 78 QLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMK-SAISLAEDEEWKRIRSLLSPT 136 P +T + +R VL +SV + + M ++ + R+R LLS Sbjct: 44 GDPGFLVTRYEDVRFVLSDPRFSVRQDLPGAPRLTEMTFESVMTTDPPVHTRLRRLLSRD 103 Query: 137 FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSL 196 FT+ +++ M P + + + L+ + + KG P + + + GV Sbjct: 104 FTARRIERMRPRLEEIAEGLLDEMEK---KGAPADIVESLAVPFPITVICELLGVP---- 156 Query: 197 NNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRM 256 G+ D + E + + ++L V Sbjct: 157 ---------MVDVARFRGWADTMVSLTGY------SMEDWTAARDALE--SYLDGLVAAK 199 Query: 257 KKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSF 316 +++ D L ++ + L+D ++ + S+I + AGYE S+ L Sbjct: 200 REN-------PGSDLLSALVAT-----AAEDNELTDHDVRSLSLILLLAGYEPASNQLGS 247 Query: 317 TLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIR-LER 375 ++ L PD +L+++ L V E +R P L R Sbjct: 248 SVLTLLRFPDRLAELRRD------------------PGLLPSAVEELMRYAPAGDGALFR 289 Query: 376 TCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFG 435 +DV I IP S V+ T A + DP+ + +P R +R + +T G Sbjct: 290 VTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDRPDNQ--------HTALG 341 Query: 436 TGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG 480 G C+G A + +++A+ +L+ F + L+ + G Sbjct: 342 HGIHFCLGAALARVELQVAIGALLRRFPRLALATDESGLRWSSPG 386 >1Q5D-A nrPDB Length = 419 Score = 210 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 78/430 (18%), Positives = 156/430 (36%), Gaps = 67/430 (15%) Query: 53 YRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECY---------SVFT 103 Y + + + ++ Y + +T + V E + S Sbjct: 24 YAEDPFPAIERLRE-ATPIF--YWDEGRSWVLTRYHDVSAVFRDERFAVSREEWESSAEY 80 Query: 104 NRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRRE 163 + K + E+ R+R L++P+FTS + + I + D L+ + Sbjct: 81 SSAIPELSDMKKYGLFGLPPEDHARVRKLVNPSFTSRAIDLLRAEIQRTVDQLLDARSGQ 140 Query: 164 AEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSI 223 E DV+ + G+ + +++ E +KF +FG L + Sbjct: 141 EE---------------FDVVRDYAEGIPMRAISALLKVPAECDEKFRRFGSATARALGV 185 Query: 224 ILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKE 283 L P + + L S+ + + L ++ +++ L + D L +++ ++ Sbjct: 186 GLVPRVDEETKTLVASV--TEGLALLHGVLDERRRNPLEN------DVLTMLLQAEAD-- 235 Query: 284 TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKA 343 LS EL A I AG +TT +++F + L P+ + ++ E Sbjct: 236 ---GSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAE--------- 283 Query: 344 PPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALH 402 + ++E LR + I R ++D+E G I KG MV + + Sbjct: 284 ---------PGLMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSAL 334 Query: 403 HDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 D ++ P+ F R + +G GP C G+ A + ++A+ + + F Sbjct: 335 RDGTVFSRPDVFDVRRDT--------SASLAYGRGPHVCPGVSLARLEAEIAVGTIFRRF 386 Query: 463 SFKPCKETQI 472 KET + Sbjct: 387 PEMKLKETPV 396 >2XKR-A nrPDB Length = 398 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 79/424 (18%), Positives = 152/424 (35%), Gaps = 65/424 (15%) Query: 70 KMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRI 129 ++ G + A + + + +F+N + P + +D Sbjct: 32 PVFRDRNG---LAAASTYQAVIDAERQP--ELFSNAGGIRPDQPALPMMIDMDDPAHLLR 86 Query: 130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSF 189 R L++ FT ++K+ IA D L+ + E+G+ ++D+ M VI G Sbjct: 87 RKLVNAGFTRKRVKDKEASIAALCDTLIDAV---CERGECDFVRDLAAPLPMAVI-GDML 142 Query: 190 GVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFL 249 GV E FL++ L FL+ + + T++ Sbjct: 143 GVR-----------PEQRDMFLRWSD--------DLVTFLSSHVSQEDFQI----TMDAF 179 Query: 250 SKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYET 309 + + + + + D + +++ S+ E LSD EL ++++ + G ET Sbjct: 180 AAYNDFTRATIAARRADPTDDLVSVLVSSEVDGER-----LSDDELVMETLLILIGGDET 234 Query: 310 TSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPV 369 T LS +L + D LQ++ L + E LR Sbjct: 235 TRHTLSGGTEQLLRNRDQWDLLQRD------------------PSLLPGAIEEMLRWTAP 276 Query: 370 AIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY 429 + R D E +G + G +++ + + D + EPE+F +R +P Sbjct: 277 VKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQR--------NPN 328 Query: 430 IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS--FKPCKETQIPLKLDTQGLLQPEKP 487 + FG G C+G + A + + L RVL+ ++ +PL+ P Sbjct: 329 SHLAFGFGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMP 388 Query: 488 IVLK 491 +V Sbjct: 389 VVFT 392 >4WPZ-A nrPDB Length = 397 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 74/420 (17%), Positives = 150/420 (35%), Gaps = 73/420 (17%) Query: 83 AITDPDVIRTVLVKECYS------VFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPT 136 +T +R VLV +S M ++ + E R+R L++ Sbjct: 41 MVTKHADVRKVLVDSRFSSKVMATAAAAMSETETGKLMNESLVGMDAPEHTRLRKLVTKA 100 Query: 137 FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSL 196 FT+ +++ + P I + L+ L +PV L F + GV Sbjct: 101 FTARRVETLRPRITELVGQLLDELETLP---RPVDLVKNFSVPLPVRVICELLGVPA--- 154 Query: 197 NNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRM 256 QD F + L + + +N+ + + Sbjct: 155 -GDQDTFHAWSNALLG------------------DWQQVVEKEAATVSLVNYFGELIAVK 195 Query: 257 KKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSF 316 +++ D + +I ++ L++ E+ A SI + AG+ETT++ +S Sbjct: 196 REN-------PADDLISELIAI-----SDGDSTLTEREIIALSIGILSAGHETTANQISM 243 Query: 317 TLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIR---L 373 L L +P+ KL+ +A + V+E LR P+ + Sbjct: 244 FLVTLLHNPEELDKLRDNREA------------------IPKAVDELLRFVPLTTTGGII 285 Query: 374 ERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYT 432 R +VE+ G +P G++V+ + DP+ + + E R + + Sbjct: 286 PRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTR--------ENNPHL 337 Query: 433 PFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKV 492 FG G +C+G + A + ++ AL +L + L+L + +++ + + + Sbjct: 338 AFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSASIIRGLESLPITW 397 >6FSH-A nrPDB Length = 398 Score = 208 bits (530), Expect = 4e-54, Method: Composition-based stats. Identities = 72/413 (17%), Positives = 130/413 (31%), Gaps = 83/413 (20%) Query: 86 DPDVIRTVLVKECYSVFTNRRSLGPVGFMKSA-----------ISLAEDEEWKRIRSLLS 134 V+R VL F+ RR P + + + E R+R LL+ Sbjct: 47 GHAVVRQVLGDH--QQFSTRRRWDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRHLLT 104 Query: 135 PTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNID 194 P FT +++ + P I + L + G P L ++F + GV D Sbjct: 105 PGFTQRRMRRLAPRIEEIV---TDRLDAMEQAGPPADLIELFADEVPGAVLCELIGVPRD 161 Query: 195 SLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVN 254 + F+ L+ SL K L + Sbjct: 162 DRD-----------------------------MFMKLCHGHLDASLSQKRRAA-LGDKFS 191 Query: 255 RMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVL 314 R + + ++K D I +++ ++D EL + + AG + S ++ Sbjct: 192 RYLLAMIARERKDPGDGFIGSIVAEH------GDTITDEELRGVCVQLMLAGDDNVSGMI 245 Query: 315 SFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIR-L 373 + L HP+ L+ + + D V+E +R V Sbjct: 246 GLGVLALLRHPEQIAALRGDDQSA------------------DRAVDELIRYLTVPYAPT 287 Query: 374 ERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTP 433 RT +DV + I +G V+ + D + + R P + Sbjct: 288 PRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR--------TPVPHVA 339 Query: 434 FGTGPRNCIGMRFALMNMKLALIRVLQNFS----FKPCKETQIPLKLDTQGLL 482 FG G +C+G + +++A + + F P +E GL Sbjct: 340 FGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMFRTSTPAYGLT 392 >3A50-A nrPDB Length = 411 Score = 208 bits (528), Expect = 6e-54, Method: Composition-based stats. Identities = 75/415 (18%), Positives = 138/415 (33%), Gaps = 73/415 (17%) Query: 52 SYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVK-----ECYSVFTNRR 106 ++ Q + + PV +T +R V + + Sbjct: 17 TFWQNPHPAYAALRAE-DPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQ 75 Query: 107 SLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEK 166 + L + + R+R L+ +FT ++ E+ P I + D L+ L Sbjct: 76 RADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEIADGLLAGLPT---D 132 Query: 167 GKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILF 226 G +++ + VI G+ + +D F + Sbjct: 133 GPVDLMREYAFQIPVQVIC-ELLGLPAE----DRDDFSAWSSVL---------------- 171 Query: 227 PFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLD-FLQLMIDSQNSKETE 285 V P D N ++ L K+ D L ++ + Sbjct: 172 -----------VDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDM---- 216 Query: 286 SHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP 345 LS EL A +++ + AG+ETT +++ + L THPD ++ L ++ Sbjct: 217 DGDRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAED----------- 265 Query: 346 TYDAVVQMEYLDMVVNETLRLFPVAIRLE-RTCKKDVEINGVFIPKGSMVVIPTYALHHD 404 + V E LR + R +DV +GV IP G MV++ A + D Sbjct: 266 -------PSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRD 318 Query: 405 PKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVL 459 + EP+ R + FG G C+G + A + ++A+ R+ Sbjct: 319 ADWMPEPDRLDITRDASGGVF--------FGHGIHFCLGAQLARLEGRVAIGRLF 365 >3ABA-A nrPDB Length = 403 Score = 208 bits (528), Expect = 7e-54, Method: Composition-based stats. Identities = 71/425 (16%), Positives = 140/425 (32%), Gaps = 69/425 (16%) Query: 74 TYEGQLPVLAITDPDVIRTVLVKECYSV-----FTNRRSLGPVGFMKSAISLAEDEEWKR 128 T+ +T + +R +L +SV + + + ++ ++ E Sbjct: 38 TFTSGHEAWLVTGYEEVRALLRDSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHTS 97 Query: 129 IRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTS 188 R LL+ FT +++ + P I + D + + +G PV L F ++ Sbjct: 98 DRKLLAKEFTVRRMQALRPNIQRIVDEHLDAIE---ARGGPVDLVKTFANAVPSMVISDL 154 Query: 189 FGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINF 248 FGV ++ QD + + + Sbjct: 155 FGVPVERRAEFQDIAEAMMRVDQDAAATEAAGMR-------------------------- 188 Query: 249 LSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYE 308 L + ++ + R + D + +I ++ + + D+ L + + A ++ Sbjct: 189 LGGLLYQLVQERRAN---PGDDLISALITTE-----DPDGVVDDMFLMNAAGTLLIAAHD 240 Query: 309 TTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP 368 TT+ ++ L PD L+++ + V E LR Sbjct: 241 TTACMIGLGTALLLDSPDQLALLRED------------------PSLVGNAVEELLRYLT 282 Query: 369 VAI-RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID 427 + ER +DVE+ GV I KG VV A DP + EPE F R Sbjct: 283 IGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITR--------R 334 Query: 428 PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKP 487 P + FG G CIG + A + +++ + + + L+ + Sbjct: 335 PAPHLAFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFRHDMVFYGVHE 394 Query: 488 IVLKV 492 + + Sbjct: 395 LPVTW 399 >6GK6-A nrPDB Length = 411 Score = 207 bits (527), Expect = 8e-54, Method: Composition-based stats. Identities = 78/426 (18%), Positives = 157/426 (36%), Gaps = 79/426 (18%) Query: 70 KMWGTYEGQLPVLAITDPDVIRTVL-----VKECYSVFTNRRSLGPVGFMKSAISLAEDE 124 +W V + DP +IR V+ Y ++R + FM + A+ Sbjct: 43 PIWVAVRYDDCVELLKDPRLIRDFRKLPDEVRRRYFPLSDRTT-----FMDQHMLDADPP 97 Query: 125 EWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVI 184 + R+R+++ F+ ++ + P I + D L+ + M++I Sbjct: 98 DHTRLRAIVQRAFSPRMMEGLRPRIQEIADGLID---------------AVIDRRRMELI 142 Query: 185 TGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKD 244 +F + + VE +F ++ I+L P F ++ Sbjct: 143 ADFAFPLPTAVIAELLGLPVEDRGRFRRWT-------KILLAPAKDREFVE-RAQPVVEE 194 Query: 245 TINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF 304 + + +K+ R D + ++ ++ E LS EL++ + + Sbjct: 195 FAAYFRALADARRKA-------PRDDLISGLLLAE-----EQEHKLSPAELSSMVFLLLV 242 Query: 305 AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETL 364 AG+ETT +++ + L +HP +++L ++ + V E L Sbjct: 243 AGHETTVHLIASGMLLLLSHPAERRRLDED------------------PGLVGSAVEEAL 284 Query: 365 RLF-PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKK 423 R P + R +D+E+ G +P G V A + DP+++ +P+ F R Sbjct: 285 RCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGR----- 339 Query: 424 DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQ 483 P + FG G C+G A + +A +L+ +I L T+ ++ Sbjct: 340 ---SPNRHIGFGGGIHFCLGAMLARIEAAIAFSTLLRRLP-------RIELATSTRDIVW 389 Query: 484 PEKPIV 489 E P + Sbjct: 390 SEWPTI 395 >5XJN-A nrPDB Length = 455 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 76/452 (16%), Positives = 149/452 (32%), Gaps = 82/452 (18%) Query: 56 GLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMK 115 + E ++ M+ G +T D I+T + + F++ + PV Sbjct: 63 NPFPAYKELRQEEPVMFDERIGYW---VVTKYDDIKTTF--DDWETFSSENAQAPVRKRG 117 Query: 116 ---------------SAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNL 160 S +S E RIR++ FT + K + P I + + Sbjct: 118 PQATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRYKALEPDIRAMV---IDRV 174 Query: 161 RREAEKGKPV-TLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPL 219 + + V + + T G +I ++ + ++ Sbjct: 175 EKMLANDQHVGDMVSDLAYDIPTITILTLIGADISMVDT-----------YKRWSDSRAA 223 Query: 220 FLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMK--KSRLNDKQKHRLDFLQLMID 277 L ++ I V + + + D H D L Sbjct: 224 MTWGDL---------------SDEEQIPHAHNLVEYWQECQRMVADAHAHGGDNLT---- 264 Query: 278 SQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDA 337 + + + + ++D E+A+ +FAG+ETT++++S L HP+ Q + Sbjct: 265 ADLVRAQQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAI------ 318 Query: 338 VLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIP 397 + + + V+E LR + R KD EI GV I +G V++ Sbjct: 319 ------------LENPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLL 366 Query: 398 TYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIR 457 + + D + EEF R + ++ + FG G C+G A + K+ L Sbjct: 367 MGSANRDEARFENGEEFDISRANARE-------HLSFGFGIHYCLGNMLAKLQAKICLEE 419 Query: 458 VLQNFS-FKPCKETQIPLKLDTQGLLQPEKPI 488 V + + I + + + P+ Sbjct: 420 VTRLVPSLHLVADKAIGFRENLSFRVPTSVPV 451 >5GWE-A nrPDB Length = 405 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 76/452 (16%), Positives = 149/452 (32%), Gaps = 82/452 (18%) Query: 56 GLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMK 115 + E ++ M+ G +T D I+T + + F++ + PV Sbjct: 13 NPFPAYKELRQEEPVMFDERIGYW---VVTKYDDIKTTF--DDWETFSSENAQAPVRKRG 67 Query: 116 ---------------SAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNL 160 S +S E RIR++ FT + K + P I + + Sbjct: 68 PQATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRYKALEPDIRAMV---IDRV 124 Query: 161 RREAEKGKPV-TLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPL 219 + + V + + T G +I ++ + ++ Sbjct: 125 EKMLANDQHVGDMVSDLAYDIPTITILTLIGADISMVDT-----------YKRWSDSRAA 173 Query: 220 FLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMK--KSRLNDKQKHRLDFLQLMID 277 L ++ I V + + + D H D L Sbjct: 174 MTWGDL---------------SDEEQIPHAHNLVEYWQECQRMVADAHAHGGDNLT---- 214 Query: 278 SQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDA 337 + + + + ++D E+A+ +FAG+ETT++++S L HP+ Q + Sbjct: 215 ADLVRAQQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAI------ 268 Query: 338 VLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIP 397 + + + V+E LR + R KD EI GV I +G V++ Sbjct: 269 ------------LENPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLL 316 Query: 398 TYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIR 457 + + D + EEF R + ++ + FG G C+G A + K+ L Sbjct: 317 MGSANRDEARFENGEEFDISRANARE-------HLSFGFGIHYCLGNMLAKLQAKICLEE 369 Query: 458 VLQNFS-FKPCKETQIPLKLDTQGLLQPEKPI 488 V + + I + + + P+ Sbjct: 370 VTRLVPSLHLVADKAIGFRENLSFRVPTSVPV 401 >1UED-A nrPDB Length = 406 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 77/410 (18%), Positives = 129/410 (31%), Gaps = 81/410 (19%) Query: 68 YGKMWGT------YEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMK------ 115 +G + G+ V +V+R +L FT R Sbjct: 36 HGPLVRIVGESSTQLGRDFVWQAHGYEVVRRILGDH--EHFTTRPQFTQSKSGAHVEAQF 93 Query: 116 -SAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKD 174 IS + E R+R +L+P FT +++ M P I D + L E G L+ Sbjct: 94 VGQISTYDPPEHTRLRKMLTPEFTVRRIRRMEPAIQSLIDDRLDLLEAE---GPSADLQG 150 Query: 175 IFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFE 234 +F + L P+D E ++ + L + Sbjct: 151 LFADP-------VGAHALCELLGIPRDDQREFVRRIRRNADLSRGLKA-----------R 192 Query: 235 ALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLE 294 A + + F + N L++ + D L MI + ++D E Sbjct: 193 AADSAAFNRYLDNLLARQ------------RADPDDGLLGMIV------RDHGDNVTDEE 234 Query: 295 LAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQME 354 L I G ET + ++ F + L +P + L + E Sbjct: 235 LKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFE------------------SPE 276 Query: 355 YLDMVVNETLRLFPVAIRL-ERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413 + VVNE +R R KDV I+G I G V+ + D +P+ Sbjct: 277 KAERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDV 336 Query: 414 FRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 R + FG G C+G A +++A + + F Sbjct: 337 LDANRAAVSD--------VGFGHGIHYCVGAALARSMLRMAYQTLWRRFP 378 >4TX3-A nrPDB Length = 404 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 71/411 (17%), Positives = 129/411 (31%), Gaps = 79/411 (19%) Query: 86 DPDVIRTVLVKE----CYSVFTNRRSLGPVGFMK-----SAISLAEDEEWKRIRSLLSPT 136 V+R VL F R +G G + + + E R+R LL+P Sbjct: 53 GHAVVRQVLGDHKRFSTRRRFDRRDEIGGTGVFRPRELVGNLMDYDPPEHTRLRHLLTPG 112 Query: 137 FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSL 196 FT +++ + P I + L + G P L ++F + GV D Sbjct: 113 FTQRRMRRLAPRIEEIV---TDRLDAMEQAGPPADLIELFADEVPGAVLCELIGVPRD-- 167 Query: 197 NNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRM 256 FL L+ SL + ++ R Sbjct: 168 ---------------------------DQAMFLQLCHRHLDASLSARKRAAA-GEAFARY 199 Query: 257 KKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSF 316 + + ++K D I +++ ++D EL + + AG + S ++ Sbjct: 200 LVAMMARERKDPGDGFIGSIVAEH------GDTITDEELRGVCVQLMLAGDDNVSGMIGL 253 Query: 317 TLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIR-LER 375 + L HP+ L+ + + D V+E +R V R Sbjct: 254 GVLALLRHPEQIAALRGDDQSA------------------DRAVDELIRYLTVPYAPTPR 295 Query: 376 TCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFG 435 T +DV + I +G V+ + D + + R P + FG Sbjct: 296 TAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR--------TPVPHVAFG 347 Query: 436 TGPRNCIGMRFALMNMKLALIRVLQNFS----FKPCKETQIPLKLDTQGLL 482 G +C+G + +++A + + F P +E GL Sbjct: 348 HGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMFRTSTPAYGLT 398 >5Z9I-A nrPDB Length = 398 Score = 204 bits (519), Expect = 6e-53, Method: Composition-based stats. Identities = 63/431 (14%), Positives = 148/431 (34%), Gaps = 68/431 (15%) Query: 48 GNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRS 107 G+ + K Y + ++W Y +++P V ++ Sbjct: 14 GHFWMRGKRPDKIVD--YDEELQLWNVYGYPESAAILSNPKVFS-----------SDTMR 60 Query: 108 LGPV----GFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRRE 163 L P+ ++ + + + +R+R L+ FT + +M + L+ + + Sbjct: 61 LDPIKLDEAIVEGDFAHTDPPKHRRLRGLVDHAFTPSLVAKMESRVHGIIHELLDGVEGK 120 Query: 164 AEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSI 223 ++ L F A ++ GV + L ++D + Sbjct: 121 SQ----FDLVAEFAAPLPLIMISDLLGVPES-------------DRALFRQWMDKMLDGS 163 Query: 224 ILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKE 283 F V E + + + + + +++ R D + ++ ++ Sbjct: 164 EKFESPETVLEQEEELHKELELLWEMR---DYWHERAAESRKRPREDLISQLVHAEVD-- 218 Query: 284 TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKA 343 + L+D +++ + + G+ TT+ +++ T+ L D +++ + Sbjct: 219 ---GQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCLDAFSDQDARVRADRS------- 268 Query: 344 PPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHH 403 + ++ E++R + R +VE+ G IPK ++++ T A + Sbjct: 269 -----------LVPALLEESMRYMSPICGVGRATNSEVEVAGTVIPKDQLLLVWTGAANR 317 Query: 404 DPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 D + + +P+ F R P + FG G C+G + A M K A+ +L Sbjct: 318 DERQFEKPDVFDAGR--------SPNAHLGFGRGIHFCLGRQLARMESKAAVEILLDRLP 369 Query: 464 FKPCKETQIPL 474 P Sbjct: 370 TLRADPANPPT 380 >2Z36-A nrPDB Length = 413 Score = 204 bits (518), Expect = 8e-53, Method: Composition-based stats. Identities = 70/418 (16%), Positives = 138/418 (33%), Gaps = 76/418 (18%) Query: 84 ITDPDVIRTVLVK---------ECYSVFT-NRRSLGPVGFMKSAISLAEDEEWKRIRSLL 133 ++ + R VL + + +FT + +L + + + E R + Sbjct: 51 VSGHEEARAVLADGRFSSDKRKDGFPLFTLDAATLQQLRSQPPLMLGMDGAEHSAARRPV 110 Query: 134 SPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNI 193 FT +L + P I D + ++ ++ PV L ++ GV Sbjct: 111 IGEFTVKRLAALRPRIQDIVDHFIDDMLATDQR--PVDLVQALSLPVPSLVICELLGVPY 168 Query: 194 DSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSV 253 + Q + + + ++ + Sbjct: 169 TDHDFFQSRTTMMVSRT-----------------------SMEDRRRAFAELRAYIDDLI 205 Query: 254 NRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSV 313 R + + D I Q + L L + + + + AG+ETT+++ Sbjct: 206 TRKES-------EPGDDLFSRQIARQRQE-----GTLDHAGLVSLAFLLLTAGHETTANM 253 Query: 314 LSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRL 373 +S + L +HP+ ++ M V E LR F +A + Sbjct: 254 ISLGVVGLLSHPEQLTVVKA------------------NPGRTPMAVEELLRYFTIADGV 295 Query: 374 E-RTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYT 432 R +DVEI GV I G V++ + + DP + +P ER ++ + Sbjct: 296 TSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVERGARH--------HL 347 Query: 433 PFGTGPRNCIGMRFALMNMKLALIRVLQNFS-FKPCKETQ-IPLKLDTQGLLQPEKPI 488 FG GP C+G A M +++ + + + + +P K D+ E P+ Sbjct: 348 AFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAVPMEDVPFKGDSVIYGVHELPV 405 >2ZBZ-A nrPDB Length = 412 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 65/433 (15%), Positives = 131/433 (30%), Gaps = 79/433 (18%) Query: 61 DTECYKKYGKMWGTYEG-QLPVLAITDPDVIRTVLVKECYSVF-------TNRRSLGPVG 112 + G + +T + R +L S + V Sbjct: 30 YAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPAFEAVR 89 Query: 113 FMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTL 172 A + E R + FT ++K M P + + + + G L Sbjct: 90 ESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEM---LAAGPTADL 146 Query: 173 KDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPV 232 F ++ GV QD + L Sbjct: 147 VSQFALPVPSMVICRLLGVPYADHEFFQDASKRLVQSTDAQSALTAR------------- 193 Query: 233 FEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSD 292 D +L + + + + + ++ + ++ + Sbjct: 194 ----------NDLAGYLDGLITQFQT-------EPGAGLVGALVA-----DQLANGEIDR 231 Query: 293 LELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQ 352 EL + +++ + AG+ETT+S+ S ++ L HP+ L+ + Sbjct: 232 EELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRS---------------- 275 Query: 353 MEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEP 411 + V E LR +A I R D+E+ G I G V++ + D + +P Sbjct: 276 --LVPGAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDP 333 Query: 412 EEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 471 + R ++ + FG G C+G A + +++ L ++ P Sbjct: 334 DALDIHRSARH--------HLAFGFGVHQCLGQNLARLELEVILNALMDRV---PTLRLA 382 Query: 472 IPLKLDTQGLLQP 484 +P+ Q +L+P Sbjct: 383 VPV---EQLVLRP 392 >6B11-A nrPDB Length = 440 Score = 201 bits (512), Expect = 5e-52, Method: Composition-based stats. Identities = 83/418 (19%), Positives = 153/418 (36%), Gaps = 70/418 (16%) Query: 78 QLPVLAITDPDVIRTVLVKECYSVFTNR-RSLGPVG---FMKSAISLAEDEEWKRIRSLL 133 PV I+ D +R +L S+ + L P ++ + + +R Sbjct: 86 GAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDGEAEASRSLLTLDPPDHGALRGHF 145 Query: 134 SPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNI 193 P F +++E+ P + Q L+ +L +G L F + + Sbjct: 146 IPEFGLRRVRELRPSVEQIVTGLLDDL---TARGDEADLLADFALPMATQVICRLLDIPY 202 Query: 194 DSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSV 253 + + Q+ ++T+ EAL L +D ++ L Sbjct: 203 EDRDYFQERTEQATR--------------------PAAGEEALEALLELRDYLDRLISG- 241 Query: 254 NRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSV 313 ++ L M+ LS ++ +++ + AG+ETT+S+ Sbjct: 242 --------KTGRESGDGMLGSMVAQAR------GGGLSHADVLDNAVLLLAAGHETTASM 287 Query: 314 LSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRL 373 ++ ++ L HP ++L V L V+E LR +A L Sbjct: 288 VTMSVLVLLQHPTAWREL------------------TVNPGLLPGAVDELLRYLSIADGL 329 Query: 374 ERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTP 433 R+ D+EI+G I G +V A + D ++EPE F R +++ + Sbjct: 330 RRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSARR--------HVA 381 Query: 434 FGTGPRNCIGMRFALMNMKLALIRVLQNFS-FKPCKETQ-IPLKLDTQGLLQPEKPIV 489 FG GP C+G A M +++AL VL+ +P + + LK D+ E P+ Sbjct: 382 FGYGPHQCLGQNLARMELEVALGAVLERLPALRPTTDVAGLRLKSDSAVFGVYELPVA 439 >5FOI-A nrPDB Length = 408 Score = 201 bits (512), Expect = 5e-52, Method: Composition-based stats. Identities = 64/419 (15%), Positives = 138/419 (32%), Gaps = 69/419 (16%) Query: 78 QLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKS----AISLAEDEEWKRIRSLL 133 P ++ + +R +LV +V R+ ++ + + E R+R + Sbjct: 55 GSPTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMF 114 Query: 134 SPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNI 193 F+ +++ M P I + D ++ L PV + + GV Sbjct: 115 ISAFSVRQVETMRPEIEKIVDGILDRLLALEP---PVDILTHLALPMSTQVICHLLGVPY 171 Query: 194 DSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSV 253 + + F + L P L + E +L V Sbjct: 172 ED-----------REFFQERSELASRPNDDRSMPALIELVE-------------YLDGLV 207 Query: 254 NRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSV 313 + E ++ EL +++ + AG+ET+++ Sbjct: 208 RTKTAHPDTG------------LLGTAVTERLLKGEITHQELVNNAVLLLAAGHETSANQ 255 Query: 314 LSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRL 373 ++ ++ L HP+ +L++ Q E + V+E LR +A L Sbjct: 256 VTLSVLTLLRHPETAAELRE------------------QPELMPNAVDELLRYHSIADGL 297 Query: 374 ERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTP 433 R D+ + I G ++I + +HD + F R ++ + Sbjct: 298 RRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHRPARH--------HVA 349 Query: 434 FGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKV 492 FG GP C+G A + M++ L ++ + + L++ + ++++ Sbjct: 350 FGYGPHQCLGQNLARLEMEVTLGKLFRRVPALRLAQEPDALRVRQGSPIFGIDELLVEW 408 >1ODO-A nrPDB Length = 408 Score = 201 bits (511), Expect = 6e-52, Method: Composition-based stats. Identities = 77/413 (18%), Positives = 139/413 (33%), Gaps = 70/413 (16%) Query: 63 ECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYS--------VFTNRRSLGPV--G 112 ++ G + +++DP +++ +L S F P+ Sbjct: 22 RTLREGGPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDARAHWPAFGEVVGTWPLALW 81 Query: 113 FMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTL 172 + A +++R L++P F++ ++ M P + LV L E G+PV L Sbjct: 82 VAVENMFTAYGPNHRKLRRLVAPAFSARRVDAMRPAVEAMVTGLVDRL-AELPAGEPVDL 140 Query: 173 KDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPV 232 + + G GV D + ++ Sbjct: 141 RQELAYPLPIAVIGHLMGVPQDRRDG----------------------FRALVDGVFDTT 178 Query: 233 FEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSD 292 + L + + + + D L+I +++ + LS Sbjct: 179 LDQAEAQANTARLYEVLDQLIAAKRAT-------PGDDMTSLLIAARDDEG--DGDRLSP 229 Query: 293 LELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQ 352 EL ++ I AGYETT +V+ ++ L T PD ++K T+ Sbjct: 230 EELRDTLLLMISAGYETTVNVIDQAVHTLLTRPDQLALVRK---------GEVTWAD--- 277 Query: 353 MEYLDMVVNETLRLFPVAIRLE-RTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYWTE 410 VV ETLR P L R D+ + +G I +G ++ A + P + + Sbjct: 278 ------VVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHED 331 Query: 411 PEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 + F R K+ + FG G C+G A M + LAL + F Sbjct: 332 ADTFDATRTVKE--------HLAFGHGVHFCLGAPLARMEVTLALESLFGRFP 376 >3TYW-A nrPDB Length = 417 Score = 200 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 68/397 (17%), Positives = 132/397 (33%), Gaps = 71/397 (17%) Query: 83 AITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSA-------ISLAEDEEWKRIRSLLSP 135 +T D +R +L S R +G + + E R R +L P Sbjct: 57 VVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRTDAPEHTRYRRMLLP 116 Query: 136 TFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDS 195 FT +++ M P + D ++ + G PV L + + G+ Sbjct: 117 AFTVRRVRAMRPAVQARVDEILDGM---LAAGGPVDLVSAYANAVSTSVICELLGI---- 169 Query: 196 LNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNR 255 P+ G + + V+ Sbjct: 170 ---PRHDLEFFRDVTRISGSRNSTAEQVSEALGGLFGLLGGLVA---------------- 210 Query: 256 MKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLS 315 +++ R D + ++ ++ +L + I I AG ETT+S+++ Sbjct: 211 ------ERREEPRDDLISKLVTDHLVP-----GNVTTEQLLSTLGITINAGRETTTSMIA 259 Query: 316 FTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLE- 374 + L P++ +L+K+ D + V+E LR+ VA + Sbjct: 260 LSTLLLLDRPELPAELRKDPD------------------LMPAAVDELLRVLSVADSIPL 301 Query: 375 RTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPF 434 R +D+E++G +P V+ +HDP+ + +PE R + F Sbjct: 302 RVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTDNH--------HVAF 353 Query: 435 GTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 471 G G C+G A + +++AL +L+ + Sbjct: 354 GYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGER 390 >6A7J-A nrPDB Length = 411 Score = 200 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 79/414 (19%), Positives = 148/414 (35%), Gaps = 67/414 (16%) Query: 84 ITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL--AEDEEWKRIRSLLSPTFTSGK 141 +TD V++ + V + +G + S+ + + +R+R+L++ T + Sbjct: 52 LTDSRVVKDINVWNAWQRGEIPADWPLIGLVNPGRSMLTVDGPDHRRLRTLVAQALTVKR 111 Query: 142 LKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFG-AYSMDVITGTSFGVNIDSLNNPQ 200 ++++ I + + L G+PV LK F M+VI+ Sbjct: 112 VEKLRAGIEALTNASLERL-AALPAGEPVDLKAEFAYPLPMNVIS--------------- 155 Query: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSR 260 + + D L + F + V D +K V K + Sbjct: 156 --------ELMGVDAADHPRLKELFEKFFSTQTPPEEVPQMMADLGTLFTKIVEEKKAN- 206 Query: 261 LNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYE 320 D +I + +E L+D E+ + I AG+ETT S++ + Sbjct: 207 ------PGDDLTSALIAA-----SEDGDHLTDEEILNTLQLIIAAGHETTISLIVNVVEA 255 Query: 321 LATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL-FPVAIRLERTCKK 379 LA HP+ ++K+ + +P + V+ ETLR P + L R + Sbjct: 256 LAIHPEQRKKV---LSGEIP---------------WEGVIEETLRWNTPTSHVLIRFATE 297 Query: 380 DVEINGVFIPKGSMVVIPTYALHHDPKYW-TEPEEFRPERFSKKKDSIDPYIYTPFGTGP 438 D+E+ +PKG +V+ AL D + + +F R P + FG GP Sbjct: 298 DIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATR--------TPNRHIAFGHGP 349 Query: 439 RNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKV 492 C G + + +AL + + F L+ + +K+ Sbjct: 350 HVCPGAALSRLEAGIALPALYERFPELDLAVPAAELRNKPIVTQNDLHDLPVKL 403 >5YSW-A nrPDB Length = 441 Score = 200 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 76/428 (17%), Positives = 139/428 (32%), Gaps = 85/428 (19%) Query: 69 GKMWGTYEG-QLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPV---------------G 112 G + P ++ + R VL +S ++R P Sbjct: 64 GPVARATLAAGDPFWLVSGYEEARAVLSDPRFS--SDRFQYHPWFKELSPEFRERLRDDK 121 Query: 113 FMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTL 172 + + E R R LL+ FT +++E+ I + V + G L Sbjct: 122 ARAGSFINMDPPEHTRYRKLLTGQFTVRRIRELGARIDEIVAGRVDAM---LAGGTTADL 178 Query: 173 KDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPV 232 F + ++ GV + Q + Sbjct: 179 MTEFAFPAPSLMICELLGVRYEDRAEFQQRASALLQMN---------------------- 216 Query: 233 FEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSD 292 + ++ D + +++ K++ D + +I + AL+D Sbjct: 217 -APVAEAVKNADALRAFMQALVTDKRA------NPAGDIISGLIHHAGADP-----ALTD 264 Query: 293 LELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQ 352 EL + + + AGY+TT+S+L ++ L P L+ + + Sbjct: 265 DELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPSRIAD------------ 312 Query: 353 MEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEP 411 V E LR V + R K+D+E G IP GS VV+ A + D ++W +P Sbjct: 313 ------AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDP 366 Query: 412 EEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS--FKPCKE 469 + R + FG G C+G + A M M+ +L+ Sbjct: 367 D-LDLTRPRG--------PHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPP 417 Query: 470 TQIPLKLD 477 ++PL+ D Sbjct: 418 EEVPLRND 425 >5FYF-A nrPDB Length = 470 Score = 198 bits (503), Expect = 5e-51, Method: Composition-based stats. Identities = 80/454 (17%), Positives = 153/454 (33%), Gaps = 60/454 (13%) Query: 27 TRTHGLFKRLGIPGPTPLPL----LGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQL-PV 81 R F IP L L + N YRQG W+ + + + P Sbjct: 46 RRPMPEFVETPIPDVNTLALEDIDVSNPFLYRQGQWRAYFKRLRDEAPVHYQKNSPFGPF 105 Query: 82 LAITDPDVIRTVLVKECYSVFTNRRSL----GPVGFMKSAISLAEDEEWKRIRSLLSPTF 137 ++T + I + V + + +F+ + P G + + RS + Sbjct: 106 WSVTRFEDI--LFVDKSHDLFSAEPQIILGDPPEGLSVEMFIAMDPPKHDVQRSSVQGVV 163 Query: 138 TSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLN 197 LKEM +I ++ +L P + +TG +D Sbjct: 164 APKNLKEMEGLIRSRTGDVLDSL--------PTDKPFNWVPAVSKELTGRMLATLLDFPY 215 Query: 198 NPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMK 257 + VE + + F N + + R K Sbjct: 216 EERHKLVEWSDRMAGAASAT------------GGEFADENAMFDDAADMARSFSRLWRDK 263 Query: 258 KSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFT 317 ++R ++ D + L+ ++ +K+ + +E + I G +TT + +S Sbjct: 264 EARRAAGEEPGFDLISLLQSNKETKDLINR----PMEFIGNLTLLIVGGNDTTRNSMSGG 319 Query: 318 LYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTC 377 L + P +KL+ + E + +V+E +R + R Sbjct: 320 LVAMNEFPREFEKLKA------------------KPELIPNMVSEIIRWQTPLAYMRRIA 361 Query: 378 KKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTG 437 K+DVE+ G I KG VV+ + + D + + P++F +R + + FG G Sbjct: 362 KQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFIIDRKDARN-------HMSFGYG 414 Query: 438 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 471 C+G R A + +++ +L+ F E Sbjct: 415 VHRCMGNRLAELQLRILWEEILKRFDNIEVVEEP 448 >1CPT-A nrPDB Length = 428 Score = 198 bits (502), Expect = 7e-51, Method: Composition-based stats. Identities = 69/426 (16%), Positives = 144/426 (33%), Gaps = 56/426 (13%) Query: 67 KYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEW 126 K+ + G+ P + +L + F S G + S S+ + Sbjct: 56 KHADVMQI--GKQP--GLFSNAEGSEILYDQNNEAFMRSISGGCPHVIDSLTSM-DPPTH 110 Query: 127 KRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITG 186 R L F ++++ I + V+ L G+ + D Y + V+ Sbjct: 111 TAYRGLTLNWFQPASIRKLEENIRRIAQASVQRLLD--FDGECDFMTDCALYYPLHVVM- 167 Query: 187 TSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTI 246 T+ GV D + ++ T+ F D ++ + + Sbjct: 168 TALGVPED----DEPLMLKLTQDFFGVHEPDEQAVAA----------PRQSADEAARRFH 213 Query: 247 NFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAG 306 ++ + ++ + + D + L+ +S+ + D + A + AG Sbjct: 214 ETIATFYDYFNGFTVDRRSCPKDDVMSLLANSKLD-----GNYIDDKYINAYYVAIATAG 268 Query: 307 YETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL 366 ++TTSS + L+ +P+ + + + +V+E +R Sbjct: 269 HDTTSSSSGGAIIGLSRNPEQLALAKSD------------------PALIPRLVDEAVRW 310 Query: 367 FPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI 426 RT D E+ G I +G +++ + + D + ++ P+EF RF Sbjct: 311 TAPVKSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRF------- 363 Query: 427 DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEK 486 P + FG G C+G A + MK+ +L E P +L + K Sbjct: 364 -PNRHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLK---SVELSGPPRLVATNFVGGPK 419 Query: 487 PIVLKV 492 + ++ Sbjct: 420 NVPIRF 425 >6M7X-A nrPDB Length = 484 Score = 197 bits (501), Expect = 8e-51, Method: Composition-based stats. Identities = 76/405 (18%), Positives = 164/405 (40%), Gaps = 26/405 (6%) Query: 55 QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFM 114 + L + +++ G ++ G ++ + P+ + + ++ S+ +R SL P Sbjct: 39 EDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKL--QQVDSLHPHRMSLEPWVAY 96 Query: 115 KS------AISLAEDEEWKRIR-SLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKG 167 + + L EW+ R L + ++ P++ + L+++ + Sbjct: 97 RQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQN 156 Query: 168 K----PVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDP---LF 220 + ++ Y+++ FG + + + + L+ F +F Sbjct: 157 ARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMF 216 Query: 221 LSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQN 280 + L + +P + + + + ++ + + + + ++ Sbjct: 217 MPRSLSRWTSPKVWKEHFEAWDC-IFQYGDNCIQKIYQELAFSRPQQYTSIVAELL---- 271 Query: 281 SKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLP 340 + LS + A S+ +TT L TL+ELA +P+VQQ L++E A Sbjct: 272 -----LNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAA 326 Query: 341 NKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYA 400 + + A ++ L + ETLRL+PV + LER D+ + IP G++V + Y+ Sbjct: 327 SISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYS 386 Query: 401 LHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMR 445 L +P + PE + P+R+ + S + + PFG G R C+G R Sbjct: 387 LGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRR 431 >1GWI-A nrPDB Length = 411 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 77/412 (18%), Positives = 140/412 (33%), Gaps = 68/412 (16%) Query: 70 KMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL--AEDEEWK 127 +W +TDP +++ + V + +G S+ + E + Sbjct: 42 PVWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPADWPLIGLANPGRSMLTVDGAEHR 101 Query: 128 RIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGT 187 R+R+L++ T +++ M I + D L+ L G V LK F + Sbjct: 102 RLRTLVAQALTVRRVEHMRGRITELTDRLLDEL---PADGGVVDLKAAFAYPLPMYVVAD 158 Query: 188 SFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEAL-NVSLFPKDTI 246 G+ L P L +FE + P++ + Sbjct: 159 LMGIEEARL------------------------------PRLKVLFEKFFSTQTPPEEVV 188 Query: 247 NFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAG 306 L++ + M + + D +I + +E+ L+D E+ + + + AG Sbjct: 189 ATLTELASIMTDTVAAKRAAPGDDLTSALIQA-----SENGDHLTDAEIVSTLQLMVAAG 243 Query: 307 YETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL 366 +ETT S++ + L+THP+ + + + VV ETLR Sbjct: 244 HETTISLIVNAVVNLSTHPEQRALV------------------LSGEAEWSAVVEETLRF 285 Query: 367 -FPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW-TEPEEFRPERFSKKKD 424 P + L R +DV + IP G +++ AL D + + F R Sbjct: 286 STPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRFDLTR------ 339 Query: 425 SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 476 + FG GP C G + M +AL + F L+ Sbjct: 340 -TSGNRHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPAAELRN 390 >5DQN-A nrPDB Length = 426 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 63/376 (16%), Positives = 118/376 (31%), Gaps = 64/376 (17%) Query: 101 VFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNL 160 V+ + V ++ + + + R+R ++S FT + + + + Sbjct: 82 VYPQDMTREAVDLQRAVLLNMDAPQHTRLRKIISRGFTPRAIGRLEDELRSRAQ----KI 137 Query: 161 RREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLF 220 + A + GV D +D + + Sbjct: 138 AQTAAAQGAGDFVEQVSCELPLQAIAELLGVPQD----DRDKLFRWSNEMTAGE------ 187 Query: 221 LSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQN 280 P + ++ ++ + I++ K D + +I++ Sbjct: 188 ---------DPEYADVDPAMSSFELISYAMKMAEER-------AVNPTEDIVTKLIEADI 231 Query: 281 SKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLP 340 E LSD E ++ AG ETT + ++ + A +PD + +KE Sbjct: 232 DGEK-----LSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNPDQWELYKKERP---- 282 Query: 341 NKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYA 400 + +E +R +RT +DVE+ GV I KG VV+ + Sbjct: 283 ----------------ETAADEIVRWATPVSAFQRTALEDVELGGVQIKKGQRVVMSYRS 326 Query: 401 LHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGT-GPRNCIGMRFALMNMKLALIRVL 459 + D + + +P F R P + FG G CIG A M + L + Sbjct: 327 ANFDEEVFEDPHTFNILR--------SPNPHVGFGGTGAHYCIGANLARMTINLIFNAIA 378 Query: 460 QNFSFKPCKETQIPLK 475 N LK Sbjct: 379 DNMPDLKPIGAPERLK 394 >6A7I-A nrPDB Length = 411 Score = 196 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 84/421 (19%), Positives = 154/421 (36%), Gaps = 76/421 (18%) Query: 84 ITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL--AEDEEWKRIRSLLSPTFTSGK 141 +TD V++ + V + +G S+ + + +R+R+L++ T + Sbjct: 52 LTDSRVVKDIDVWNAWRRGEIPMDWPLIGLANPGRSMLTVDGADHRRLRTLVAQALTVKR 111 Query: 142 LKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFG-AYSMDVITGTSFGVNIDSLNNPQ 200 ++ + I + + L G+PV LK F M+VI+ Sbjct: 112 VERLRAGIEALTNASLEKL-AALPAGEPVDLKAEFAYPLPMNVIS--------------- 155 Query: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSR 260 + + D L + F + V D +K V+ + + Sbjct: 156 --------ELMGVDAADHPRLKELFEKFFSTQTPPEEVPQMMADLGALFTKIVDAKRTN- 206 Query: 261 LNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYE 320 D +I + +E+ L+D E+ + I AG+ETT S++ + Sbjct: 207 ------PGDDLTSALIAA-----SENGDHLTDEEIVNTLQLIIAAGHETTISLIVNVVEA 255 Query: 321 LATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL-FPVAIRLERTCKK 379 L THP+ ++K+ ++ + D V+ ETLR P + L R + Sbjct: 256 LQTHPEQRKKV---LNGEIG---------------WDGVIEETLRWNTPTSHVLIRFATE 297 Query: 380 DVEINGVFIPKGSMVVIPTYALHHDPKYW-TEPEEFRPERFSKKKDSIDPYIYTPFGTGP 438 D+E+ +PKG ++I AL D + + EF R P + FG GP Sbjct: 298 DIEVGDKILPKGEGLIISFGALGRDEEQYGPTAGEFDATR--------TPNRHIAFGHGP 349 Query: 439 RNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGT 498 C G + + +AL + + F P + +P KPIV + D + Sbjct: 350 HVCPGAALSRLEAGIALPALYERF---PELDLAVPASDLRN------KPIVTQNDLHELP 400 Query: 499 L 499 + Sbjct: 401 V 401 >1F4U-A nrPDB Length = 368 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 74/449 (16%), Positives = 165/449 (36%), Gaps = 90/449 (20%) Query: 57 LWKFDTECYKK----Y-GKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPV 111 ++ + +E KK Y G +W + + + + + L Y G + Sbjct: 1 MYDWFSEMRKKDPVYYDGNIWQVFSYRYTKEVLNNFSKFSSDL--TGYHERLEDLRNGKI 58 Query: 112 GF---MKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGK 168 F + + ++ +RS+ + F+ KL+ + I + L+ ++ + Sbjct: 59 RFDIPTRYTMLTSDPPLHDELRSMSADIFSPQKLQTLETFIRETTRSLLDSIDPRED--- 115 Query: 169 PVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPF 228 + ++ G+ I+ +KF ++ L L F Sbjct: 116 --DIVKKLAVPLPIIVISKILGLPIEDK-----------EKFKEWSDLVAFRLGKPGEIF 162 Query: 229 LTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHK 288 + L + + KD +N ++ V+R+ + Sbjct: 163 ELGK-KYLELIGYVKDHLNSGTEVVSRVV-----------------------------NS 192 Query: 289 ALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYD 348 LSD+E I+ + AG ETT++++S ++ + ++ Q++++E Sbjct: 193 NLSDIEKLGYIILLLIAGNETTTNLISNSVIDFTRF-NLWQRIREE-------------- 237 Query: 349 AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 + E LR P +R R K+ V++ I +G V + + + D + + Sbjct: 238 -----NLYLKAIEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVF 292 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK 468 + E+F P+R +P + FG+G C+G A + ++A+ + F Sbjct: 293 HDGEKFIPDR--------NPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFRHIEIL 344 Query: 469 ETQ-IPLKLDTQGLLQPEKPIVLKVDSRD 496 +T+ +P +L K +V+++ S + Sbjct: 345 DTEKVP-----NEVLNGYKRLVVRLKSNE 368 >6F0B-A nrPDB Length = 395 Score = 195 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 74/409 (18%), Positives = 148/409 (36%), Gaps = 72/409 (17%) Query: 78 QLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPV------GFMKSAISLAEDEEWKRIRS 131 P + + +RTVL +S + R + + ++ + +R+R Sbjct: 37 GTPAHVFSGYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHRRLRG 96 Query: 132 LLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGV 191 ++ F ++ + P I + ++ L A +D+ A+++ V + T F + Sbjct: 97 TIAREFLPKHIELLRPAIREIVQGVLDGLAETAP------PQDMLEAFAVPVASATVFRL 150 Query: 192 NIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSK 251 L + LT + + ++ +D + + Sbjct: 151 ---------------------------LGIPAEDRALLTRCVKGVVSAVGSEDEGAEVFR 183 Query: 252 SVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTS 311 ++ + D + D L + + +E K L+ E ++ I GY+TT+ Sbjct: 184 TLGEYIGGLVQDPSELPEDSLIRRLVTGPYQE----KQLTFHETIGVILMLIVGGYDTTA 239 Query: 312 SVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA- 370 S +S +L A P+ + + E + ++V E LR V+ Sbjct: 240 STISLSLVSYALQPEKFSVVHE------------------HPERIPLLVEELLRYHTVSQ 281 Query: 371 IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI 430 + L R +DVE+ GV + G MVV + D + P+E +R S Sbjct: 282 LGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDRPSV--------P 333 Query: 431 YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK--PCKETQIPLKLD 477 + FG GP C+G A + ++ A+ V++ C +P + D Sbjct: 334 HVGFGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLACALEDLPFRHD 382 >4ZGX-A nrPDB Length = 489 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 76/403 (18%), Positives = 163/403 (40%), Gaps = 26/403 (6%) Query: 57 LWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKS 116 L + +++ G ++ G ++ + P+ + + ++ S+ R L P + Sbjct: 41 LHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKL--QQVDSLHPCRMILEPWVAYRQ 98 Query: 117 ------AISLAEDEEWKRIR-SLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGK- 168 + L EW+ R L + ++ P++ + L+++ + Sbjct: 99 HRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNAR 158 Query: 169 ---PVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDP---LFLS 222 + ++ Y+++ FG + + + + L+ F +F+ Sbjct: 159 GSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMP 218 Query: 223 IILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSK 282 L +++P + + + + ++ + ++ +H + ++ Sbjct: 219 RSLSRWISPKVWKEHFEAWDC-IFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLK---- 273 Query: 283 ETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNK 342 LS + A S+ +TT+ L TL+ELA +PDVQQ L++E A + Sbjct: 274 -----AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASI 328 Query: 343 APPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALH 402 + A ++ L + ETLRL+PV + LER D+ + IP G++V + Y+L Sbjct: 329 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLG 388 Query: 403 HDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMR 445 + + PE + P+R+ + S + + PFG G R C+G R Sbjct: 389 RNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRR 431 >3IVY-A nrPDB Length = 433 Score = 192 bits (487), Expect = 4e-49, Method: Composition-based stats. Identities = 66/390 (16%), Positives = 123/390 (31%), Gaps = 65/390 (16%) Query: 84 ITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLK 143 I+ + + F N + + + + + R+R ++S FT + Sbjct: 82 ISRHSDVFSSYENGVIPRFKNDIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVG 141 Query: 144 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF 203 + + + + A G ++ + + I G GV + Sbjct: 142 RLHDELQERAQKIA---AEAAAAGSGDFVEQVSCELPLQAIAGL-LGVPQEDRGKLFHWS 197 Query: 204 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND 263 E T P + ++ + I + K K+ Sbjct: 198 NEMTGN-------------------EDPEYAHIDPKASSAELIGYAMKMAEEKAKN---- 234 Query: 264 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT 323 D + +I + E LSD E ++ AG ETT + ++ + A Sbjct: 235 ---PADDIVTQLIQADIDGEK-----LSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAE 286 Query: 324 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 383 HPD + + + + +E +R +RT +D E+ Sbjct: 287 HPDQWE--------------------LYKKVRPETAADEIVRWATPVTAFQRTALRDYEL 326 Query: 384 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGT-GPRNCI 442 +GV I KG VV+ + + D + + +P F R +P + FG G CI Sbjct: 327 SGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILR--------NPNPHVGFGGTGAHYCI 378 Query: 443 GMRFALMNMKLALIRVLQNF-SFKPCKETQ 471 G A M + L V + KP + Sbjct: 379 GANLARMTINLIFNAVADHMPDLKPISAPE 408 >3A1L-A nrPDB Length = 425 Score = 191 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 66/417 (15%), Positives = 132/417 (31%), Gaps = 73/417 (17%) Query: 63 ECYKKYGKMWGTYEGQ--LPVLAITDPDVIRTVLVKECY----SVFTNRRSLGPV----- 111 Y++ + T G + D + VL V + PV Sbjct: 27 RRYREAAPVHRTASGPGKPDTYYVFTYDDVVRVLSNRRLGRNARVASGDTDTAPVPIPTE 86 Query: 112 -----GFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEK 166 +++ + + +RSLL+ F+ + + P IA+ L+ LR + Sbjct: 87 HRALRTVVENWLVFLDPPHHTELRSLLTTEFSPSIVTGLRPRIAELASALLDRLRAQRRP 146 Query: 167 GKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILF 226 L + F A ++ G+ + + + + L Sbjct: 147 ----DLVEGFAAPLPILVISALLGIPEEDH---------------TWLRANAVALQEAST 187 Query: 227 PFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETES 286 ++ + + V+R +D + + ++ Sbjct: 188 TRARDGRGYARAEAASQEFTRYFRREVDRRGGDDRDDLLTLLV------------RARDT 235 Query: 287 HKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPT 346 LS + + + AG+ETT++ L+ + L H DV +L+ Sbjct: 236 GSPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELR-------------- 281 Query: 347 YDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPK 406 E V E +R P + R +D+ + IP+GS VV + + DP Sbjct: 282 ----TTPESTPAAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPA 337 Query: 407 YWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 + +P+ R ++++ FG G C+G A ++ L +L Sbjct: 338 RFPDPDVLDVHRAAERQ--------VGFGLGIHYCLGATLARAEAEIGLRALLDGIP 386 >6HQW-A nrPDB Length = 445 Score = 191 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 58/356 (16%), Positives = 116/356 (32%), Gaps = 61/356 (17%) Query: 118 ISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFG 177 + + R ++P FT K+ EM I + ++ +L Sbjct: 129 FIAMDRPDHTGQRRTVAPAFTPAKMVEMEAEIRRRTASVLDSLP---------------- 172 Query: 178 AYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALN 237 +G D ++ L L + V L Sbjct: 173 -----------WGERFDWVDKVSIELTTGMLAILFGFPWADRRLLTFWSDWAGDVELTLA 221 Query: 238 VSLFPKDTINFLSKSVNRMKKSRLNDKQKHR-LDFLQLMIDSQNSKETESHKALSDLELA 296 L FL + + ++ Q D + +MI S E+ +S E Sbjct: 222 RELADTRF-GFLGEMAHYFQRLWGARMQAPPSGDLISMMIHS------EAMNHMSPQEFM 274 Query: 297 AQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYL 356 ++ I G +TT + +S ++ L PD ++ L+++ + Sbjct: 275 GNLVLLIVGGNDTTRNTMSGIVHALDKFPDQRELLERDAS------------------LI 316 Query: 357 DMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRP 416 V E +R + RT D E+ G I G V++ + + D + P++ Sbjct: 317 PNAVQECIRYVTPLAHMRRTATADTELFGNQIKAGEKVILWYISANRDETVFENPDKLMV 376 Query: 417 ERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVL-QNFSFKPCKETQ 471 +R + ++ + FG G C+G R A + +++ L + + + E + Sbjct: 377 DRPNARR-------HLSFGHGIHRCVGARLAELQLRILLEEMHERRMRVRVAGEVE 425 >6M7L-A nrPDB Length = 404 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 74/401 (18%), Positives = 132/401 (32%), Gaps = 80/401 (19%) Query: 69 GKMWGTYEGQLPVLA--ITDPDVIRTVLVKECYSVFTNRRSLG-PVGFMKSAISLAEDEE 125 G + + DV+R VL E + + + + E Sbjct: 48 GPLVRIPLEDGSAVHWFALGYDVVREVLGSEKFDKRVIGTHFNHQEMALPGNLLQLDPPE 107 Query: 126 WKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT-LKDIFGAYSMDVI 184 R+R +++P ++ +++ + P + D +L A G PV L+++ G + V Sbjct: 108 HTRLRRMVAPAYSVRRMQALEPRVQAIVD---DHLDTMASTGPPVEFLREVAGPMAARVA 164 Query: 185 TGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKD 244 + L P D E + G L Sbjct: 165 C--------EFLGIPLDDRGELIRLTAHRGG-------------------KRRRVLNGHA 197 Query: 245 TINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF 304 + ++ + R+++ D + M+ + +SD ELA + + Sbjct: 198 YLAYMRELAARLRR--------DPGDGMLGMVA------RDHGADISDEELAGLCAVVMN 243 Query: 305 AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETL 364 + E T S L+ L HP+ L++ + E + V E + Sbjct: 244 SSVEQTESCLAAGTLLLLEHPEQFALLRE------------------RPELGEQAVEEIV 285 Query: 365 RLFPVAIRL-ERTCKKDVEINGVFIPKGSMVVIPTYALHH-DPKYWTEPEEFRPERFSKK 422 R V L RT +DVEI G I KG V A + DP + F R + Sbjct: 286 RYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL----DGFDITRKESR 341 Query: 423 KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 + FG G +C+G A M +++A ++ F Sbjct: 342 --------HVAFGHGIHHCLGAPLARMELRIAFTTLVSRFP 374 >6HQG-A nrPDB Length = 425 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 70/446 (15%), Positives = 148/446 (33%), Gaps = 65/446 (14%) Query: 56 GLWKFDTECYKKYGKM-WGT--YEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSL---- 108 +W + K+ + WG +E ++T + I V + VF++ ++ Sbjct: 36 TMWPYFERLRKE-DPVHWGVSPHEDVGGYWSVTKYNDIMA--VDTNHEVFSSEPTIVLPD 92 Query: 109 GPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGK 168 F + + R + P L + PII + ++ +L E Sbjct: 93 PADDFTLPMFIAMDPPKHDVQRKTVQPIVAPNHLAYLEPIIRERAGKILDDLPIGEEINW 152 Query: 169 PVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPF 228 + ++ + D E +K + + + Sbjct: 153 VDKVSIELTTMTLATL---------------FDFPWEDRRKLTFWSDVATSAPESGILGT 197 Query: 229 LTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHK 288 P + +++ + N + D + ++ ES K Sbjct: 198 TDPEEHENLRRQTLFECVDYFMRLWNERVNAPPKP------DLISMLAH------GESTK 245 Query: 289 ALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYD 348 + +E I+ I G +TT + +S ++ L +PD +KL++ Sbjct: 246 NMDRMEYLGNLILLIVGGNDTTRNTISGSVLALHQNPDQDRKLRE--------------- 290 Query: 349 AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 + +V+ET+R + R K+D E+ G I +G V + + + D + Sbjct: 291 ---NPGLIPAMVSETIRWQTPLAYMRRRAKRDFELGGKTIREGDKVAMWYVSGNRDEEVI 347 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK 468 P ++ ER ++ + FG G C+G R A + +K+ +L F Sbjct: 348 DRPNDYWIERPRVRQ-------HLSFGFGVHRCVGNRLAELQLKIIWEEILARFPRLEVV 400 Query: 469 ETQIPLKLDTQGLLQ-PEKPIVLKVD 493 P ++ + + E P+V+ Sbjct: 401 GP--PRRVYSSFVKGYEELPVVIPTR 424 >2X9P-A nrPDB Length = 404 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 81/452 (17%), Positives = 146/452 (32%), Gaps = 98/452 (21%) Query: 61 DTECYKKYGKMWGTYE-GQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGP----VGFMK 115 + G + +T ++ +L E F+ Sbjct: 31 LLRALQDRGPIHRVRTPAGDEAWLVTRHAELKQLLHDERIGRTHPDPPSAAQYVRSPFLD 90 Query: 116 SAISLAEDEEWKRI----RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT 171 IS A+ E +R R LL+P F++ ++ EM P + + D L+ + G Sbjct: 91 LLISDADAESGRRQHAETRRLLTPLFSARRVLEMQPKVEEAADTLLDAFIAQGPPG---- 146 Query: 172 LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTP 231 D+ G ++ + V + + P E T LD Sbjct: 147 --DLHGELTVPF----ALTVLCEVIGVPPQRRAELTTLLAGIAKLD-------------- 186 Query: 232 VFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALS 291 + D +++ V + D D L+ Sbjct: 187 --DREGAVRAQDDLFGYVAGLVEHKRAEPGPDIISRLND-----------------GELT 227 Query: 292 DLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVV 351 + +A ++ +FAG ++ +S++ + LA HPD + + D Sbjct: 228 EDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPD--------------- 272 Query: 352 QMEYLDMVVNETLRLFPV--AIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409 + V E LR ++ R +D+E GV I G +V+ + D + +T Sbjct: 273 ---VMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFT 329 Query: 410 EPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKE 469 PEEF R P + FG G +CIG A + ++ ++ Sbjct: 330 GPEEFDAAR--------TPNPHLTFGHGIWHCIGAPLARLELRTMFTKLFTRLP------ 375 Query: 470 TQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSG 501 L+PE P V ++ ++G LSG Sbjct: 376 -----------ELRPELP-VEQLRLKEGQLSG 395 >3P3Z-A nrPDB Length = 416 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 62/361 (17%), Positives = 118/361 (32%), Gaps = 60/361 (16%) Query: 104 NRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRRE 163 FM + + + +R+R L + FT ++ + P + + L+ L Sbjct: 86 GTPEGPVRDFMVDFLQSLDGADHRRLRGLATHPFTPRRITAVQPFVRSTVEQLIDKL--- 142 Query: 164 AEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSI 223 F ++ G ++ + +E+ L + + + Sbjct: 143 --PQGDFDFVQHFPHPLPALVMCQLLGFPLEDYDTVGRLSIET---NLGLALSNDQDILV 197 Query: 224 ILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKE 283 + L + + + + K + D ++ + + Sbjct: 198 KVE--------------------QGLGRMFDYLVAAIEKRKVEPGDDLTSDIVRAFHDG- 236 Query: 284 TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKA 343 L D EL + AGYETT+ L+ +Y+ A HPD K+++ Sbjct: 237 -----VLDDYELRTLVATVLVAGYETTNHQLALAMYDFAQHPDQWMKIKE---------- 281 Query: 344 PPTYDAVVQMEYLDMVVNETLRLFPV-AIRLERTCKKDVEINGVFIPKGSMVVIPTYALH 402 E V E LR P + R +D E+NGV IP G+ V + + H Sbjct: 282 --------NPELAPQAVEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAH 333 Query: 403 HDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 462 DP+ + + + F + FG GP C+G A + + A+ + Sbjct: 334 RDPRVFADADRFDITVKREA-------PSIAFGGGPHFCLGTALARLELTEAVAALATRL 386 Query: 463 S 463 Sbjct: 387 D 387 >3RWL-A nrPDB Length = 426 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 63/402 (15%), Positives = 119/402 (29%), Gaps = 70/402 (17%) Query: 68 YGKMWGTYEGQLPVLAITDPDVIRT------VLVKECYSVFTNRRSLGPVGFMKSAISLA 121 +G W + + T+ D+ + +++ + + P Sbjct: 61 FGPYWSITKYNDIMHVDTNHDIFSSDAGYGGIIIDDGIQKGGDGGLDLP------NFIAM 114 Query: 122 EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSM 181 + R +SP L + I + + L G+ D Sbjct: 115 DRPRHDEQRKAVSPIVAPANLAALEGTIRERVSKTLDGL----PVGEEFDWVDRVSIEIT 170 Query: 182 DVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLF 241 + T F + + L P V Sbjct: 171 TQMLATLFDFPFE-----------------ERRKLTRWSDVTTAAPGGGVVESWDQRKTE 213 Query: 242 PKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSII 301 + + N + D + ++ S + + ++ E ++ Sbjct: 214 LLECAAYFQVLWNERVNKDPGN------DLISMLAHS------PATRNMTPEEYLGNVLL 261 Query: 302 FIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVN 361 I G +TT + ++ + L +PD KL+ ++ +V Sbjct: 262 LIVGGNDTTRNSMTGGVLALHKNPDQFAKLKA------------------NPALVETMVP 303 Query: 362 ETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421 E +R + RT D E+ G I KG VV+ Y+ + D + PEEF +R Sbjct: 304 EIIRWQTPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDRP-- 361 Query: 422 KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 P + FG G C+G R A M +++ +L FS Sbjct: 362 -----RPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFS 398 >2RFC-A nrPDB Length = 343 Score = 184 bits (467), Expect = 8e-47, Method: Composition-based stats. Identities = 64/401 (15%), Positives = 139/401 (34%), Gaps = 80/401 (19%) Query: 83 AITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKL 142 + ++ VL+ + +F++ + ++ E K R + +P F K+ Sbjct: 14 HVYKYSDVKHVLMNDK--IFSSNPGNRYSNAGGISFITMDNPEHKEFRDISAPYFLPSKI 71 Query: 143 KEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDP 202 + I + + L++N+ + D+I+ + + ++ ++ Sbjct: 72 NDYKDFIEETSNDLIKNIDNK------------------DIISEYAVRLPVNIISKILGI 113 Query: 203 FVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLN 262 F + F ++ + + +F D+ ++ Sbjct: 114 PDSDMPLFKLWSDYIIGNKRDENFNYVNNRMVSRLLEIFKSDSHGIINVL---------- 163 Query: 263 DKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELA 322 + + ++ L+ E ++ I G ETT++++ + + Sbjct: 164 ------------------AGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVID 205 Query: 323 THPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLE-RTCKKDV 381 +PD+ ID L N++ V ETLR + L R +D Sbjct: 206 ENPDI-------IDDALKNRSG--------------FVEETLRYYSPIQFLPHRFAAEDS 244 Query: 382 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNC 441 IN I KG V++ + + D ++ EP+ F+ R ++ FG G C Sbjct: 245 YINNKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGR---------REMHLAFGIGIHMC 295 Query: 442 IGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLL 482 +G A + +AL +L +F + L LD + +L Sbjct: 296 LGAPLARLEASIALNDILNHFKRIKIDYKKSRL-LDNKMVL 335 >3NC3-A nrPDB Length = 441 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 72/417 (17%), Positives = 149/417 (35%), Gaps = 60/417 (14%) Query: 52 SYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSL--G 109 ++ + + ++ ++ + YE + I+ +R +L + +FT + + Sbjct: 50 QFQNNPYAYFSQLREE-DPVH--YEESIDSYFISRYHDVRYIL--QHPDIFTTKSLVERA 104 Query: 110 PVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKP 169 ++ +E R ++ +F L + P+I Q + L L E+GK Sbjct: 105 EPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALDHLSPLIKQNAENL---LAPYLERGKS 161 Query: 170 VTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFL 229 L + FG +T G++ +K ++ F++ + Sbjct: 162 -DLVNDFGKTFAVCVTMDMLGLDKRDH-----------EKISEWHSGVADFITS-----I 204 Query: 230 TPVFEALNVSLFPKDTI-NFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHK 288 + EA SL+ + + +L + + D + ++ S+ Sbjct: 205 SQSPEARAHSLWCSEQLSQYLMPVIKERR-------VNPGSDLISILCTSEY-----EGM 252 Query: 289 ALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYD 348 ALSD ++ A + + A E L+ +Y L +P+ + + Sbjct: 253 ALSDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRS------------ 300 Query: 349 AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 + + ETLR P + R +D + G+ I K ++V A + DP+ + Sbjct: 301 ------LVPRAIAETLRYKPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAF 354 Query: 409 TEPEEFRPERFS--KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 +P+ F R K + FG+G NC+G FA +++ VL Sbjct: 355 EQPDVFNIHREDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKMR 411 >1UE8-A nrPDB Length = 367 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 76/429 (17%), Positives = 154/429 (35%), Gaps = 83/429 (19%) Query: 69 GKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGF---MKSAISLAEDEE 125 GK+W ++ + + + D + L Y+ G V F + + ++ Sbjct: 18 GKVWNLFKYEDCKMVLNDHKRFSSNL--TGYNDKLEMLRSGKVFFDIPTRYTMLTSDPPL 75 Query: 126 WKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVIT 185 +R+L + F L + + L+ L E + + F ++ Sbjct: 76 HDELRNLTADAFNPSNLP--VDFVREVTVKLLSELDEE------FDVIESFAIPLPILVI 127 Query: 186 GTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDT 245 G+N D + + L+ G D +F Sbjct: 128 SKMLGINPDVKKVKDWSDLVA----LRLGRADEIFS-----------------------I 160 Query: 246 INFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFA 305 + ++ KK + K K +D + ++ LS+LE I+ + A Sbjct: 161 GRKYLELISFSKKELDSRKGKEIVDLTGKI----------ANSNLSELEKEGYFILLMIA 210 Query: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR 365 G ETT++++ + + + ++D V + L V E LR Sbjct: 211 GNETTTNLIGNAIEDFTLY--------------------NSWDYVREKGALK-AVEEALR 249 Query: 366 LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDS 425 P +R R K+ V+I I +G +V + + + D + + +P+ F P+R Sbjct: 250 FSPPVMRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDR------- 302 Query: 426 IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPE 485 P + FG+G C+G A + ++AL + F K + + K+D + +L Sbjct: 303 -TPNPHLSFGSGIHLCLGAPLARLEARIALEEFAKKFRVKEIVKKE---KIDNE-VLNGY 357 Query: 486 KPIVLKVDS 494 + +V++V+ Sbjct: 358 RKLVVRVER 366 >3MGX-A nrPDB Length = 415 Score = 181 bits (460), Expect = 5e-46, Method: Composition-based stats. Identities = 68/387 (17%), Positives = 134/387 (34%), Gaps = 70/387 (18%) Query: 110 PVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIA-QYGDVLVRNLRREAEKGK 168 P + ++E E+ +++R L+ P + +++ + + GDVL R L G+ Sbjct: 98 PDNSGGRMMVVSEHEQHRKLRKLVGPLLSRAAARKLAERVRIEVGDVLGRVLD-----GE 152 Query: 169 PVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPF 228 G + GV + + D L+ F Sbjct: 153 VCDAATAIGPRIPAAVVCEILGVPAEDEDMLID-------------------LTNHAFGG 193 Query: 229 LTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHK 288 +F+ + + + + + + +K + D + ++ Sbjct: 194 EDELFDGMTPRQAHTEILVYFDELITARRK-------EPGDDLVSTLVT---------DD 237 Query: 289 ALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYD 348 L+ ++ + G ETT ++ ++ LAT P + L+ V Sbjct: 238 DLTIDDVLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTALRDGSADV---------- 287 Query: 349 AVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW 408 D VV E LR A+ + R DV ING +P G+ VV A + DP + Sbjct: 288 --------DTVVEEVLRWTSPAMHVLRVTTADVTINGRDLPSGTPVVAWLPAANRDPAEF 339 Query: 409 TEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK 468 +P+ F P R P + FG G +C+G A + + + L + + S Sbjct: 340 DDPDTFLPGR--------KPNRHITFGHGMHHCLGSALARIELSVVLRVLAERVS---RV 388 Query: 469 ETQIPLKLDTQGLLQPEKPIVLKVDSR 495 + + ++Q + + ++ R Sbjct: 389 DLEREPAWLRAIVVQGYRELPVRFTGR 415 >3SN5-A nrPDB Length = 491 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 88/514 (17%), Positives = 174/514 (33%), Gaps = 89/514 (17%) Query: 35 RLGIPGPTPL-----PLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDV 89 R G PL P LG L + +F +K+G ++ V IT+P Sbjct: 8 RRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLS 67 Query: 90 IRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKR-IRSLLSPTFTSGKLKEMFPI 148 VL Y F +WK+ +L + F + M Sbjct: 68 YHKVLCHGKY--F----------------------DWKKFHFALSAKAFGHRSIDPMDGN 103 Query: 149 IAQ-----------------YGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGV 191 + + ++ NL+R PV+ A+ + + + V Sbjct: 104 TTENINDTFIKTLQGHALNSLTESMMENLQRIMRP--PVSSNSKTAAWVTEGMYSFCYRV 161 Query: 192 NIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEAL--NVSLFPKDTINFL 249 ++ + + + ++ F VF AL + + T + Sbjct: 162 MFEAGYLT----IFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNA 217 Query: 250 SKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYET 309 + + + K++ + + L ++ DLE A ++ ++A Sbjct: 218 REKLAESLRHENLQKRESISELISL-----RMFLNDTLSTFDDLEKAKTHLVVLWASQAN 272 Query: 310 TSSVLSFTLYELATHPDVQQKLQKEIDAVL----------PNKAPPTYDAVVQMEYLDMV 359 T ++L+++ +P+ + +E+ L N + + + LD + Sbjct: 273 TIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSI 332 Query: 360 VNETLRLFPVAIRLERTCKKDVEI----NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFR 415 + E+LRL ++ + RT K+D + I K ++ + +H DP+ + +P F+ Sbjct: 333 IKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFK 391 Query: 416 PERFSKKKDSID----------PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK 465 +R+ + Y Y PFG+G C G FA+ +K LI +L F + Sbjct: 392 YDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELE 451 Query: 466 PCKE----TQIPLKLDTQGLLQPEKPIVLKVDSR 495 + + G+L P I K + Sbjct: 452 LIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFK 485 >5DE9-A nrPDB Length = 410 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 72/420 (17%), Positives = 132/420 (31%), Gaps = 77/420 (18%) Query: 54 RQGLWKFDTECYKKYGKMWGTYE--GQLPVLAITDPDVIRTVLVKECY--SVFTNR---R 106 TE ++ G + G+ +T D +R V + +R R Sbjct: 23 GSDFDPVLTELMRE-GPVTRISLPNGEGWAWLVTRHDDVRLVTNDPRFGREAVMDRQVTR 81 Query: 107 SLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEK 166 + A+ + + R+R ++ FT+ ++ + D LV + R Sbjct: 82 LAPHFRPARGAVGFLDPPDHTRLRRSVAAAFTARGVERVRERSRGMLDELVDAMLRA--- 138 Query: 167 GKPVTLKD-IFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIIL 225 G P L + + + + VI + + D + Sbjct: 139 GPPADLTEAVLSPFPIAVIC-----------------------ELMGVPATDRHSMHTWT 175 Query: 226 FPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETE 285 L+ A + + S + S D L+ Sbjct: 176 QLILSSSHGAEVSERAKNEMNAYFSDLIGLRSDSAGE-------DVTSLL------GAAV 222 Query: 286 SHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP 345 ++ E +++ G E ++ + L + P++ ++L+ E Sbjct: 223 GRDEITLSEAVGLAVLLQIGG-EAVTNNSGQMFHLLLSRPELAERLRSE----------- 270 Query: 346 TYDAVVQMEYLDMVVNETLRLFP--VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHH 403 E ++E LR P A+ L R +DVEI GV I G V + A + Sbjct: 271 -------PEIRPRAIDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANR 323 Query: 404 DPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 DP+ + +P+ ER P + FG GP C G A + +L + VL Sbjct: 324 DPEVFPDPDRIDFER--------SPNPHVSFGFGPHYCPGGMLARLESELLVDAVLDRVP 375 >6DCD-A nrPDB Length = 424 Score = 179 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 72/435 (16%), Positives = 143/435 (32%), Gaps = 83/435 (19%) Query: 74 TYEGQLPVLAITDPDVIRTVLVKECYSVFTN----RRSLGPVGFMKSA------------ 117 Q V+A+T + V F+N P+ F + Sbjct: 33 LRLPQYGVVAVTGYEEATAVYKDT--DSFSNCVALGGPFPPLPFAPNGDDVNAQIDAHRE 90 Query: 118 -------ISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPV 170 + + E R RS+LS T +LK+ + + D + E Sbjct: 91 QFPMYEHMVTMDPPEHSRARSILSRLLTPSRLKQNEEFMWRLADRQLDEFLGAGE----C 146 Query: 171 TLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLT 230 + ++ GV D + V + + G LD + + +L Sbjct: 147 EFISEYAKPFATLVIADLLGVPED--DRKDFRVVLGADRMGRVGALDHESVGVNPLQWLD 204 Query: 231 PVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKAL 290 F A + +++ R D L + + Sbjct: 205 DKFSAY-----------------------IEDRRRQPRNDVLTALATAT----YPDGSTP 237 Query: 291 SDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAV 350 +++ + AG ETT+ +L+ + L PD+Q++L++ Sbjct: 238 EVIDVVRSATFLFAAGQETTAKLLTAAMRVLGDRPDIQRRLRE----------------- 280 Query: 351 VQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTE 410 + + E+LR+ R +K + G+ I G++V++ A + DP+ + + Sbjct: 281 -NRSLIPNFIEESLRMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFED 339 Query: 411 PEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 470 P EFR +R + ++ + F G +C G A + +++L R+L E Sbjct: 340 PHEFRLDRPNVRE-------HMAFARGVHSCPGGPLARVEGRVSLERILDRMLDIAINED 392 Query: 471 QIPLKLDTQGLLQPE 485 + D + +P Sbjct: 393 RHGPADDRRYTYEPT 407 >5H1Z-A nrPDB Length = 407 Score = 179 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 61/408 (14%), Positives = 117/408 (28%), Gaps = 63/408 (15%) Query: 65 YKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDE 124 + +G W P++ + + + + + P + Sbjct: 42 HSDFGPYWSVSSY-KPIITV---ESLPDLYSSAGGITLADFIENNPTDVRMPMFIAMDRP 97 Query: 125 EWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVI 184 + R ++P FT ++ M I ++ +L E P D + Sbjct: 98 KHTGQRRTVAPAFTPSEMVRMSDNIRMRTAEVLDSL----EWNTPFDWVDTVSVELTTQM 153 Query: 185 TGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKD 244 F + + K F I L E L Sbjct: 154 LAILFDFPWE--------------ERRKLTFWSDWAGDIELVKNEELRLERLRHMYECGG 199 Query: 245 TINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF 304 L + + D + +MI S E + +E I+ I Sbjct: 200 YFQNLWNA---------KIGKPPTPDLISMMIHSDAMAE------MDQMEFLGNLILLIV 244 Query: 305 AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETL 364 G +TT + +S Y L PD + KL+ + + V E + Sbjct: 245 GGNDTTRNTMSAVAYGLDLFPDQRAKLEAD------------------PSMIPNTVQEII 286 Query: 365 RLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKD 424 R + RT D E+ G I G + + + + D + + +R + ++ Sbjct: 287 RWQTPLAHMRRTATVDSELEGQQIKAGDKLALWYISANRDESVFENADRIIVDRPNARR- 345 Query: 425 SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVL-QNFSFKPCKETQ 471 + FG G C+G R A + + + L + + E + Sbjct: 346 ------HLAFGHGIHRCVGARLAELQIAVLLEEMAKRRMRVNVLGEPE 387 >3TKT-A nrPDB Length = 450 Score = 177 bits (449), Expect = 8e-45, Method: Composition-based stats. Identities = 71/388 (18%), Positives = 136/388 (35%), Gaps = 55/388 (14%) Query: 83 AITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSA-------ISLAEDEEWKRIRSLLSP 135 + T L +VFT R + + + + ++R L Sbjct: 82 VMKASKDNATFLNNPKSTVFTLRVGEMMAKAITGGSPHLVESLVQMDAPKHPKLRRLTQD 141 Query: 136 TFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDS 195 F L + I + + + + E+G + L + Y + V+ GV + Sbjct: 142 WFMPKNLARLDGEIRKIANEAIDRMLGAGEEGDFMAL--VAAPYPLHVVMQI-LGVPPE- 197 Query: 196 LNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNR 255 + P+ F+ FG D L L P + V+ + + + Sbjct: 198 -DEPKMLFLTQQ----MFGGQDEDMNKSGL-KDLPPEQISQIVAGAVAEFERYFAGLAAE 251 Query: 256 MKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLS 315 +++ +D + + + + +SD + A II AG++TTS+ + Sbjct: 252 RRRNPTDD------------VATVIANAVVDGEPMSDRDTAGYYIITASAGHDTTSASSA 299 Query: 316 FTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLER 375 LA PD+ +++ + + L +V E +R R Sbjct: 300 GAALALARDPDLFARVKADRN------------------LLPGIVEEAIRWTTPVQHFMR 341 Query: 376 TCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFG 435 T D E+ G I G +++ A +HDP + EP +F P R + + + FG Sbjct: 342 TAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTRPANR--------HLAFG 393 Query: 436 TGPRNCIGMRFALMNMKLALIRVLQNFS 463 G C+G+ A + M++ L +L Sbjct: 394 AGSHQCLGLHLARLEMRVLLDVLLDRVD 421 >5L1U-A nrPDB Length = 401 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 72/412 (17%), Positives = 128/412 (31%), Gaps = 81/412 (19%) Query: 66 KKYGKMWGTYEGQLPVLAITDPDVIRTVLVK----------ECYSVFTNRRSLGPVGFMK 115 +K G + +T D +RT+L + + R + + Sbjct: 28 QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALAAGD 87 Query: 116 SAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDI 175 E ++RSLL P F++ +L+ M I + D L+ L A PV L + Sbjct: 88 D--HETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQLAASAP---PVDLHRV 142 Query: 176 FGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEA 235 ++ GV PL + F+ Sbjct: 143 LSFRLPTMVVCDLLGV--------------------------PLADRERFGQWARGTFDQ 176 Query: 236 LNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLEL 295 + + + + + R+ + D L +I E ALSD ++ Sbjct: 177 SDNEHSANTFQQVVDYMLELVARKRV----EPGDDILSELI-------AEKDGALSDADI 225 Query: 296 AAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEY 355 A + GYETT + L +P + +L ++ Sbjct: 226 AHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAED------------------PGL 267 Query: 356 LDMVVNETLRLF----PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEP 411 V E LRL + R D+ + I G V++ A ++D + + + Sbjct: 268 APAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDG 327 Query: 412 EEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 F R + P + FG G R+CIG A + + R+ + Sbjct: 328 GLFDLTR-------VRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLP 372 >5LIV-A nrPDB Length = 450 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 63/394 (15%), Positives = 138/394 (35%), Gaps = 66/394 (16%) Query: 83 AITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKL 142 + I T F+ R + G + ++ + +E R+R + + F + Sbjct: 92 ILLRKSHITTAYRDTA--TFSTR--MFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAV 147 Query: 143 KEMFPI-IAQYGDVLVRNLRREAEKGKP-VTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200 + + + +V L GKP V L + F + G FG + L+ Sbjct: 148 SQYEERFVRPISEQVVDRL-----AGKPRVDLLEDFAMELPRRVIGELFGFPAEKLHETD 202 Query: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSR 260 + + ++ + + V+ + L +++ Sbjct: 203 ERVRAMLRGLVR-------------------MHDPAAVAESQRAYGETLGLITEVVERES 243 Query: 261 LNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSII-FIFAGYETTSSVLSFTLY 319 + + L+ + + + +E + Q ++ I GYETTS +++ T++ Sbjct: 244 RDTSDTLLGEILRTL----------KAEHMDTIEASRQIVLSLILGGYETTSWLVANTIH 293 Query: 320 ELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKK 379 L HPD +++++ L + E +R P + + R ++ Sbjct: 294 ALLAHPDTLARVRQD------------------PSLLPAAIEEGMRWCPSSFGVLRMVER 335 Query: 380 DVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPR 439 DV ++ + G++V + A ++D + PE + +R ++ FG G Sbjct: 336 DVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRKPLPAANV-------FGGGAH 388 Query: 440 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 473 C+G A M ++ L +L F + P Sbjct: 389 FCVGAPLARMEARVGLQALLARFPGLRAVPEERP 422 >6F88-A nrPDB Length = 400 Score = 175 bits (443), Expect = 4e-44, Method: Composition-based stats. Identities = 63/394 (15%), Positives = 137/394 (34%), Gaps = 66/394 (16%) Query: 83 AITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKL 142 + I T F+ R + G + ++ + +E R+R + + F + Sbjct: 42 ILLRKSHITTAYRDTA--TFSTR--MFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAV 97 Query: 143 KEMFPI-IAQYGDVLVRNLRREAEKGKP-VTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200 + + + +V L GKP V L + F + G FG + L+ Sbjct: 98 SQYEERFVRPISEQVVDRL-----AGKPRVDLLEDFAMELPRRVIGELFGFPAEKLHETD 152 Query: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSR 260 + + ++ + + V+ + L +++ Sbjct: 153 ERVRAMLRGLVR-------------------MHDPAAVAESQRAYGETLGLITEVVERES 193 Query: 261 LNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSII-FIFAGYETTSSVLSFTLY 319 + + L+ + + + +E + Q ++ I GYETTS +++ T++ Sbjct: 194 RDTSDTLLGEILRTL----------KAEHMDTIEASRQIVLSLILGGYETTSWLVANTIH 243 Query: 320 ELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKK 379 L HPD +++++ L + E +R P + R ++ Sbjct: 244 ALLAHPDTLARVRQD------------------PSLLPAAIEEGMRWCPSNFGVLRMVER 285 Query: 380 DVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPR 439 DV ++ + G++V + A ++D + PE + +R ++ FG G Sbjct: 286 DVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRKPLPAANV-------FGGGAH 338 Query: 440 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 473 C+G A M ++ L +L F + P Sbjct: 339 FCVGAPLARMEARVGLQALLARFPGLRAVPEERP 372 >2FR7-A nrPDB Length = 412 Score = 174 bits (442), Expect = 5e-44, Method: Composition-based stats. Identities = 71/436 (16%), Positives = 141/436 (32%), Gaps = 75/436 (17%) Query: 66 KKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKS-------AI 118 ++ G + Y + V + + VL F + R +G F K I Sbjct: 44 REAGPV--VYLDKWNVYGVARYAEVYAVLNDPL--TFCSSRGVGLSDFKKEKPWRPPSLI 99 Query: 119 SLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGA 178 A+ R R++LS + +K + A D + L A G + D+ A Sbjct: 100 LEADPPAHTRTRAVLSKVLSPATMKRLRDGFAAAADAKIDELL--ARGGNIDAIADLAEA 157 Query: 179 YSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNV 238 Y + V F + ++ + + ++ F P + Sbjct: 158 YPLSV-----FPDAMGLKQEGRENLLP--------------YAGLVFNAFGPPNELRQSA 198 Query: 239 SLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQ 298 ++++ R N + D+ ++ E Sbjct: 199 IERSAPHQAYVAEQCQ-----RPNLAPGGFGACIHAFSDT---------GEITPEEAPLL 244 Query: 299 SIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDM 358 + AG +TT + ++ +Y LA PD +L+ + Sbjct: 245 VRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRAD------------------PSLARN 286 Query: 359 VVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418 E +R RT +DVE+ G I +G V++ + + DP+ W +P+ + R Sbjct: 287 AFEEAVRFESPVQTFFRTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRYDITR 346 Query: 419 FSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT 478 + + FG+G C+G A + ++ L + + E PLK Sbjct: 347 KTSG--------HVGFGSGVHMCVGQLVARLEGEVVLAALARKV---AAIEIAGPLKRRF 395 Query: 479 QGLLQPEKPIVLKVDS 494 L+ + + +++ Sbjct: 396 NNTLRGLESLPIQLTP 411 >2UUQ-A nrPDB Length = 414 Score = 174 bits (441), Expect = 8e-44, Method: Composition-based stats. Identities = 53/356 (14%), Positives = 112/356 (31%), Gaps = 60/356 (16%) Query: 118 ISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFG 177 + + + R L+S FT +++ + P + ++ + LR + Sbjct: 96 MVMQDPPVHTEFRKLVSRGFTPRQVETVEPTVRKFVVERLEKLRANGGG----DIVTELF 151 Query: 178 AYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALN 237 ++ GV + + + A Sbjct: 152 KPLPSMVVAHYLGVPEEDWTQFDG--------------------------WTQAIVAANA 185 Query: 238 VSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAA 297 V ++ + + + + D + ++ + + ++ LS + A Sbjct: 186 VDGATTGALDAVGSMMAYFTGLIERRRTEPADDAISHLVAAGVGADGDTAGTLS---ILA 242 Query: 298 QSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLD 357 + + G +T + +L ++ L PD ++ L + + + Sbjct: 243 FTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEG------------------IP 284 Query: 358 MVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYW-TEPEEFRP 416 V E LRL L RT +DV I IP G V++ + + D + + + E Sbjct: 285 DAVEELLRLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDV 344 Query: 417 ERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQI 472 R P F G +C+G A M ++AL +L E++I Sbjct: 345 TR--------CPRNILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRI 392 >4DO1-A nrPDB Length = 410 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 72/441 (16%), Positives = 137/441 (31%), Gaps = 76/441 (17%) Query: 61 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKS---- 116 D + + G + Y + V + + VL F + R +G F K Sbjct: 38 DQQTLRDAGPV--VYLDKWNVYGVARYAEVHAVLNDPT--TFCSSRGVGLSDFKKEKPWR 93 Query: 117 ---AISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLK 173 I A+ R R++LS + +K + A D V L + L Sbjct: 94 PPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLA 153 Query: 174 DIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVF 233 + AY + V F + ++ + + F P L P Sbjct: 154 E---AYPLSV-----FPDAMGLKQEGREHLLPYAG-LVFNAFGPPNELRQTAIERSAPHQ 204 Query: 234 EALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDL 293 +N R N + D+ ++ Sbjct: 205 AYVNEQC------------------QRPNLAPGGFGACIHAFTDT---------GEITPD 237 Query: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353 E + AG +TT + + +Y LA P Q+L+ + Sbjct: 238 EAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSD------------------P 279 Query: 354 EYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413 E +R RT ++VE+ G I +G V++ + + DP+ W++P+ Sbjct: 280 TLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDL 339 Query: 414 FRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 473 + R + + FG+G C+G A + ++ L + + + P Sbjct: 340 YDITRKTSG--------HVGFGSGVHMCVGQLVARLEGEVMLSALARKV---AAIDIDGP 388 Query: 474 LKLDTQGLLQPEKPIVLKVDS 494 +K L+ + + +K+ Sbjct: 389 VKRRFNNTLRGLESLPVKLTP 409 >4PWV-A nrPDB Length = 446 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 70/431 (16%), Positives = 139/431 (32%), Gaps = 75/431 (17%) Query: 83 AITDPDVIRTVLVKECYSVFTNRRSLGPV-----GFMKSAISLAEDEEWKRIRSLLSPTF 137 ++ + + L + +++ + + +R++L +F Sbjct: 78 VVSRYADVMALYKDNKKLTSEKGNVLVTLLAGGDSAAGKMLAVTDGAMHRGLRNVLLKSF 137 Query: 138 TSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLN 197 + LK + I LV A +G+ D+ ++ I+ GV Sbjct: 138 SPQALKPIVDQIRVNTTRLV---VDAARRGECDFAADVAEQIPLNTISDL-LGVPA---- 189 Query: 198 NPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMK 257 ++ ++ K L D A + L + + + S+ V + Sbjct: 190 ADREFLLKLNKSALSSEDAD---------------QSATDAWLARNEILLYFSELVAERR 234 Query: 258 KSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFT 317 K D + ++ +S K L++ + I G ET+ + + Sbjct: 235 A-------KPTEDVISVLANSMVD-----GKPLTEEVIVLNCYSLILGGDETSRLSMIDS 282 Query: 318 LYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTC 377 + +PD + L+ L+ E LR A+ R Sbjct: 283 VQTFTQYPDQWELLRDGKVT------------------LESATEEVLRWATPAMHFGRRA 324 Query: 378 KKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTG 437 D+E++G I G +V + + + D + + +P F R P + FG G Sbjct: 325 VTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNR--------SPNKHITFGYG 376 Query: 438 PRNCIGMRFALMNMKLALIRVLQNFS--FKPCKETQIPLKLDTQGL------LQPEKPIV 489 P C+G + L L+ ++ F+ E Q GL +QP + + Sbjct: 377 PHFCLGAYLGRAEVHALLDA-LRTYTTGFEITGEPQRIHSNFLTGLSRLPVRIQPNEAAI 435 Query: 490 LKVDSRDGTLS 500 DS +G S Sbjct: 436 AAYDSDNGVRS 446 >6GII-A nrPDB Length = 479 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 58/404 (14%), Positives = 123/404 (30%), Gaps = 68/404 (16%) Query: 83 AITDPDVIRTVLVK-------ECYSVFTNRRSLGPVGFMKSAISLA------EDEEWKRI 129 +T D I+ + F + + + ++ Sbjct: 103 VVTRYDTIKQIFRDPVTFSPSNVLQSFAQPSAEVRQVLERYGYAFNRTLVNEDEPMHLER 162 Query: 130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSF 189 R +L F S L E P++ + V D++ + Sbjct: 163 RRVLMEPFASEHLAEHEPMVRELVRRAVNRFIDTGR---------------ADLVDQMIW 207 Query: 190 GVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFL 249 V + + +K +F ++ F +P E L V+ F Sbjct: 208 EVPFTVALHFLGVDDDDREKMRRFAIAH----TVNAFGRPSPE-EQLAVAETVGQFWQFC 262 Query: 250 SKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYET 309 + + +M+++ + ++ ++D L + I A +ET Sbjct: 263 GEVLEKMRRTADGPG----------WMRYSIRQQKLYPDVVTDSYLHSMMQAIIVAAHET 312 Query: 310 TSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPV 369 T + L L H V +++ + + E LR Sbjct: 313 TVFATTNALKTLLEHETVWREICAD------------------PSLIPAAAEECLRYNGP 354 Query: 370 AIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY 429 R ++VE+ GV +P G+ +++ + +HD ++ +PE F R + + Sbjct: 355 VAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFDIGRSNASE------ 408 Query: 430 IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 473 + FG G C+G M M++ + + + E + Sbjct: 409 -HLNFGYGAHQCLGRNLGRMEMQIMIEELSRRLPHMRLAEQRFD 451 >5HDI-A nrPDB Length = 404 Score = 167 bits (423), Expect = 1e-41, Method: Composition-based stats. Identities = 71/432 (16%), Positives = 142/432 (32%), Gaps = 80/432 (18%) Query: 55 QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRR-------- 106 Q + + G + A+ D + + + F++ Sbjct: 17 QDPYPLYERM-RAAGSVHRI--ANSDFYAVCGWDAVNEAIGRP--EDFSSNLTATMTYTA 71 Query: 107 -------SLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVL-VR 158 + P+G ++ A+D R L+ + +++ M Q D L V Sbjct: 72 EGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWVD 131 Query: 159 NLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDP 218 ++ + + + M V+ + + P + K +G+ Sbjct: 132 GMQDGCIEW----MGAMANRLPMMVVA--------ELIGLPDPDIAQLVK----WGY--- 172 Query: 219 LFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDS 278 + L L + + + + ++ + +R R + L + + Sbjct: 173 --AATQLLEGLVENDQLVAAGVALMELSGYIFEQFDR-------AAADPRDNLLGELATA 223 Query: 279 QNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAV 338 S E L L + AG E+T+++L ++ LAT PD+QQ+++ Sbjct: 224 CASGE------LDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRA----- 272 Query: 339 LPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPT 398 E L + ETLR P R + ++G +P S +++ Sbjct: 273 -------------NPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLW 319 Query: 399 YALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRV 458 A + DP + P EFR +R K + FG G C+G A + ++ L + Sbjct: 320 GAANRDPAQFEAPGEFRLDRAGGKG-------HISFGKGAHFCVGAALARLEARIVLRLL 372 Query: 459 LQNFSFKPCKET 470 L S + Sbjct: 373 LDRTSVIEAADV 384 >3BUJ-A nrPDB Length = 397 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 74/384 (19%), Positives = 143/384 (37%), Gaps = 66/384 (17%) Query: 74 TYEGQLPVLAITDPDVIRTVLVKECYSVFTNRR----SLGP---VGFMKSAISLAEDEEW 126 + G V ++ +R VL E ++ RR +GP + I ++ + Sbjct: 28 VHRGAHRVWYVSRFADVRAVLGDERFARTGIRRFWTDLVGPGLLAEIVGDIILFQDEPDH 87 Query: 127 KRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITG 186 R+R ++ P F+ L+ + P+IA D L L+ +MDV+ Sbjct: 88 GRLRGVVGPAFSPSALRRLEPVIAGTVDDL---------------LRPALARGAMDVVDE 132 Query: 187 TSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTI 246 ++ + + ++ ++ L + + + Sbjct: 133 LAYPLALRAVLGLLGLPAADWGAVGRWSRDVGRTL------------DRGASAEDMRRGH 180 Query: 247 NFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAG 306 +++ + ++++ +++ D L LM+D+ + +S E+ + + FIF G Sbjct: 181 AAIAEFADYVERALARRRREGGEDLLALMLDAHDRG------LMSRNEIVSTVVTFIFTG 234 Query: 307 YETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL 366 +ET +S + + L HPD L++ + + L V E LR Sbjct: 235 HETVASQVGNAVLSLLAHPDQLDLLRR------------------RPDLLAQAVEECLRY 276 Query: 367 FPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI 426 P R DVE+ G + + +VV+ A + DP+ + P++F ER Sbjct: 277 DPSVQSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIER-------- 328 Query: 427 DPYIYTPFGTGPRNCIGMRFALMN 450 DP FG G R C+G A Sbjct: 329 DPVPSMSFGAGMRYCLGSYLARTQ 352 >6BLD-A nrPDB Length = 419 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 58/395 (14%), Positives = 122/395 (30%), Gaps = 59/395 (14%) Query: 80 PVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTS 139 ++A++ + V + +F N + + + ++R L+S FT Sbjct: 69 DIVAVSRTN---EVFLSGNGVLFENVP--AELLEASQSFLAMDPPRHTKLRKLVSAAFTP 123 Query: 140 GKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNP 199 +++ + I +V LR +D + + + I +L++ Sbjct: 124 RQVRRIEDSIKINAKGIVDELRMAGGG--------------VDFVEHCAKELPIRTLSDM 169 Query: 200 QDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKS 259 ++ + P L V + ++ ++ S+ ++ Sbjct: 170 VGIPEADRERVAHAADALVSWADPRYLNGREP----LAVLFENQMYLHQVAASLAAERRD 225 Query: 260 RLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLY 319 R D D +++++ L+D ++AA ++ AG +TT +S L Sbjct: 226 RPGD------DLFSALVNAEVD-----GDRLADADVAAFFVLLAVAGNDTTRQTISHGLK 274 Query: 320 ELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKK 379 L P + L + D + V E +R + RT Sbjct: 275 ALTDFPSQKAWLLADFDTRIGT-----------------AVEELVRWATPVMTFRRTAAA 317 Query: 380 DVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPR 439 D E+ G I G VV+ + + D + PE R Sbjct: 318 DFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGFGGGGVH------- 370 Query: 440 NCIGMRFALMNMKLALIRVLQNF-SFKPCKETQIP 473 C+G A ++ +L + +P Sbjct: 371 FCLGAHLARAQLRAIFGELLVQLPDIQAGDPVYVP 405 >6HQD-A nrPDB Length = 420 Score = 164 bits (416), Expect = 6e-41, Method: Composition-based stats. Identities = 66/447 (14%), Positives = 129/447 (28%), Gaps = 74/447 (16%) Query: 54 RQGLWKFDTECYKK----------YGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFT 103 R GL + ++ YG W + V T+ V + S Sbjct: 31 RDGLHPYFERLRREDPVHYCKASEYGPYWSITKFSDIVAIDTNHKVFSS--DHTNGSFVL 88 Query: 104 NRRSLGPVGFMKSAISL--AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLR 161 + +L V + + + R ++SP L I + ++ L Sbjct: 89 DDTTLNAVDGGIYLPNFLGMDPPKHDVHRMVVSPIVAPQNLLRFEATIRERTKRVLSELP 148 Query: 162 REAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFL 221 G + ++ L D Sbjct: 149 ---------------------------IGEEFNWVDRVSIELTTMMLATLLDFPFDDRRK 181 Query: 222 SIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNS 281 +T V + + + + + D + ++ S Sbjct: 182 LTRWSDIITTRPGYGLVDSWEQRESELMECLAYFQRLYAERQAMPPKPDLISMLAHSPEM 241 Query: 282 KETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPN 341 ++ L+ + + I G +TT S +S + +P K++ Sbjct: 242 QD------LTPTDFLGTLALLIVGGNDTTRSSMSGSAMACHLYPQEFDKVR--------- 286 Query: 342 KAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYAL 401 L V+ E +R + RT +DVE G I KG VV+ + Sbjct: 287 ---------NNRALLASVIPEVVRWQTPIAHMRRTALEDVEFRGKQIRKGDKVVMWYLSG 337 Query: 402 HHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN 461 + D + P +F +R + + FG G C+G R A + +K+ + + Sbjct: 338 NRDDEVIDRPMDFIADRPRARH-------HLSFGFGIHRCLGNRLAELQLKILWEEMCER 390 Query: 462 F-SFKPCKET-QIPLKLDTQGLLQPEK 486 + + C E ++P L + P + Sbjct: 391 YSRIEVCGEPVRVPSNLVHGYIDIPVR 417 >5HIW-A nrPDB Length = 398 Score = 164 bits (416), Expect = 6e-41, Method: Composition-based stats. Identities = 71/394 (18%), Positives = 124/394 (31%), Gaps = 64/394 (16%) Query: 82 LAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGK 141 + + DV+ + E +S T G MK A+ E R+R L + + Sbjct: 41 VVLRGADVVAVLRDSETFSTRTYD-----TGIMKGALVTLGGEAHTRMRRLFNAVLSPRV 95 Query: 142 LKEMF-PIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200 + + +V L R+ L D F +T FG+ + Sbjct: 96 ISRYEEATVTPVARRVVERLVRKER----AELFDDFAISMPMGVTSALFGLPEE------ 145 Query: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSR 260 + + L + ++ P V + ++ + Sbjct: 146 --------RIAENDALIRKMIRSVVMPQDPVVVAEGRSA----------HAAMEAQLREI 187 Query: 261 LNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYE 320 + H D L I E + + I YETTS +L+ L Sbjct: 188 AEREVAHPSDTLLGEIARAIVAEGLGGVEACE----GVVLTLILGSYETTSWMLANLLVA 243 Query: 321 LATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKD 380 L HPD +L++ Q L + E+ R A + R +++ Sbjct: 244 LLAHPDAMNQLRQ------------------QPSLLPQAIEESTRWCSSAAGIVRFVERE 285 Query: 381 VEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRN 440 I G + G+++ + A H+D + + PE F R P FG G Sbjct: 286 ATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHR--------RPVGMLNFGGGLHY 337 Query: 441 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPL 474 C+G A M ++ + +L+ F T P Sbjct: 338 CVGAPLARMEARVGVSLLLERFPALRADPTVQPT 371 >3OO3-A nrPDB Length = 384 Score = 164 bits (415), Expect = 7e-41, Method: Composition-based stats. Identities = 70/414 (16%), Positives = 133/414 (32%), Gaps = 83/414 (20%) Query: 84 ITDPDVIRTVLVKECYSVFTNRRSL---GPVGFMKSAISLAEDEEWKRIRSLLSPTFTSG 140 +T D +R +L F++ R + + + + + R+R ++P +++ Sbjct: 44 VTGHDEVRAILADH--ERFSSMRPVDDEADRALLPGILQAYDPPDHTRLRRTVAPAYSAR 101 Query: 141 KLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQ 200 +++ + P I + + + + G PV I GV D Sbjct: 102 RMERLRPRIEEIVEECLDDFESV---GAPVDFVRHAAWPIPAYIACEFLGVPRDDQAELS 158 Query: 201 DPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSR 260 ES + L + LT Sbjct: 159 RMIRESRESRLPRQRTLSGLGIVNYTKRLT------------------------------ 188 Query: 261 LNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYE 320 + K++ D + +I ++ E +SD ELA + + E ++ L+ + Sbjct: 189 -SGKRRDPGDGMIGVIVREHGAE------ISDEELAGLAEGNLIMAAEQMAAQLAVAVLL 241 Query: 321 LATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIR-LERTCKK 379 L THPD L++ + E +D E LR + R Sbjct: 242 LVTHPDQMALLRE------------------KPELIDSATEEVLRHASIVEAPAPRVALA 283 Query: 380 DVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPR 439 DV + G I G ++ A + P + F R + + FG G Sbjct: 284 DVRMAGRDIHAGDVLTCSMLATNRAP-----GDRFDITR--------EKATHMAFGHGIH 330 Query: 440 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVD 493 +CIG A + +++AL V+ F + L+ +P +P V+ Sbjct: 331 HCIGAPLARLQLRVALPAVVGRFPSLRLAVPEEDLRF------KPGRPAPFAVE 378 >3WEC-A nrPDB Length = 419 Score = 164 bits (415), Expect = 7e-41, Method: Composition-based stats. Identities = 77/458 (16%), Positives = 149/458 (32%), Gaps = 99/458 (21%) Query: 52 SYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVI-------RTVLVKECYSVFTN 104 +++ + + + + G V T D + + + T+ Sbjct: 21 TFKADPYPVYARLRTEL-PIHRSALGAWIVADYTSCDKVLRSRLFGKDFANSTFFDHLTS 79 Query: 105 RRSLGPVGFMKSAI-------SLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLV 157 F+ I L + E R+R L+S FT M I+ V Sbjct: 80 MMGEDMPPFLGLGIDGDARPFMLTDPPEHTRLRGLVSDAFTRSTTTSMDDIVLSAASSAV 139 Query: 158 RNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLD 217 R+L + + ++ + ++V++ G+ + + F E + L G LD Sbjct: 140 RHLEHCTDA-----VSEVAEPFPVEVLSSI-LGIP----DKDRGRFSEWSN--LVAGVLD 187 Query: 218 PLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMID 277 F ++ + R + + +D+ + + Sbjct: 188 INF-------------------------------AIPKEVADRRSAAIEESIDYFRTLAT 216 Query: 278 SQNSKE---------TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQ 328 S N+ E + LS E+AA ++ AG ETTS+ + L + H D Sbjct: 217 SGNAPEGLVRRLSEVSHGGDQLSVDEIAATCLLITVAGQETTSNTIGNMLITFSRHADQF 276 Query: 329 QKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFI 388 ++++ ++++ V E LR P A R +D E++G I Sbjct: 277 EQVRA------------------NPQFIENAVAEVLRFEPPAHEAGRIALEDCEVSGANI 318 Query: 389 PKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFAL 448 KG V++ + + + + F R +G G +C+G A Sbjct: 319 TKGDAVMVLLASGNR--EAVERGDTFSVTRPDV--------SSLSYGRGIHHCLGSALAN 368 Query: 449 MNMKLALIRVLQNFSFKPCKETQIPLKL-DTQGLLQPE 485 ++ L + Q + E P+ GL PE Sbjct: 369 SMLQHFLRELSQRYR---SIEVAEPINYKPGMGLRGPE 403 >2NZA-A nrPDB Length = 413 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 63/404 (15%), Positives = 123/404 (30%), Gaps = 74/404 (18%) Query: 69 GKMWGTYE--GQLPVLAITDPDVIRTVLVKECY--SVFTNR---RSLGPVGFMKSAISLA 121 G + G+ T D ++ + + + T R R +++ A Sbjct: 40 GPLTRVRLPHGEGWAWLATRYDDVKAITNDPRFGRAEVTQRQITRLAPHFKPRPGSLAFA 99 Query: 122 EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSM 181 + + R+R ++ FT G K + P + D LV + +G P L + Sbjct: 100 DQPDHNRLRRAVAGAFTVGATKRLRPRAQEILDGLVDGI---LAEGPPADLVERVLEPFP 156 Query: 182 DVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLF 241 + GV P + + + + Sbjct: 157 IAVVSEVMGV--------------------------PAADRERVHSWTRQIISTSGGAEA 190 Query: 242 PKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSII 301 + L + ++R + L + ET E + Sbjct: 191 AERAKRGLYGWITETVRARAGSEGGDVYSMLGAAVGRGEVGET---------EAVGLAGP 241 Query: 302 FIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVN 361 G E + + LY L T ++ ++++ + ++ Sbjct: 242 LQIGG-EAVTHNVGQMLYLLLTRRELMARMRE------------------RPGARGTALD 282 Query: 362 ETLRLFP--VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF 419 E LR ++ L R +DVE++G I G V + A + DP + +P+ +R Sbjct: 283 ELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDR- 341 Query: 420 SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 DP + +G G C G A M +L + +L+ Sbjct: 342 -------DPNPHLAYGNGHHFCTGAVLARMQTELLVDTLLERLP 378 >5HH3-A nrPDB Length = 397 Score = 162 bits (409), Expect = 4e-40, Method: Composition-based stats. Identities = 62/404 (15%), Positives = 123/404 (30%), Gaps = 74/404 (18%) Query: 77 GQLPVLAITDPDVIRTVLVKECYSV--FTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLS 134 G T D IR VL + +S + G ++ + E R+R +++ Sbjct: 50 GGRTAWLATGYDEIRQVLSSDDFSARLLYGGTAAGITW--PGFLTQYDPPEHTRLRRMVA 107 Query: 135 PTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNID 194 P F ++++ P + + + + G PV FG T G+ D Sbjct: 108 PAFAVRRMQKFQPQVERVVQDSLDAIEAL---GGPVDFVPRFGWSVATTATCDFLGIPRD 164 Query: 195 SLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVN 254 + S + + + +++K Sbjct: 165 DQADLARSLHASRTE-----------------------RSGKRRTAAGNKFMTYMNKMTA 201 Query: 255 RMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVL 314 R ++ D +++ E ++D EL + + AG + + L Sbjct: 202 RTRRD-------PGDDMFGVVV-------REYGDEITDAELTGVAAFVMGAGADQVARFL 247 Query: 315 SFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPV-AIRL 373 + + +A P+ L+++ D V ++E +R Sbjct: 248 AAGAWLMADDPEQFALLREKPDTV------------------PDWLDEVIRYLTTDEKTH 289 Query: 374 ERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEP-EEFRPERFSKKKDSIDPYIYT 432 R DV I I G V A + + + P + F R + + Sbjct: 290 PRVATDDVRIGDHLIKAGDTVTCSLLAANR--RNFPRPEDRFDITRVRPE--------HL 339 Query: 433 PFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 476 FG G +C+G A + + A+ + F E ++L Sbjct: 340 AFGHGIHHCLGRSLAELVFRTAIPALAHRFPTLRLAEPHREIRL 383 >2WIY-A nrPDB Length = 394 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 58/421 (13%), Positives = 125/421 (29%), Gaps = 63/421 (14%) Query: 52 SYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPV 111 +R + + + + ++ + ++ + SV GP Sbjct: 17 EFRNNPYPWYRRLQQDH----PVHKLEDGTYLVSRYADVSHFAKLPIMSVEPGWADAGPW 72 Query: 112 GFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT 171 ++ +R + FT + + LV +L E G+ + Sbjct: 73 AVASDTALGSDPPHHTVLRRQTNKWFTPKLVDGWV----RTTRELVGDLLDGVEAGQVIE 128 Query: 172 LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTP 231 + V + D + + E+ Sbjct: 129 ARRDLAVVPTHVTMARVLQLPEDDADAVMEAMFEAM------------------------ 164 Query: 232 VFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLD-FLQLMIDSQNSKETESHKAL 290 + ++ + D ++ L DK+ + D ++D+ + E + Sbjct: 165 LMQSAEPADGDVDRAAVAFGYLSARVAEMLEDKRVNPGDGLADSLLDAARAGE------I 218 Query: 291 SDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAV 350 ++ E A ++F G+ +++ + A P+V + + A Sbjct: 219 TESEAIATILVFYAVGHMAIGYLIASGIELFARRPEVFTAFRNDESARA----------- 267 Query: 351 VQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTE 410 ++NE +R+ P + R +DVEI GV I GS + A + DP+ + + Sbjct: 268 -------AIINEMVRMDPPQLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDD 320 Query: 411 PEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 470 P+ F R FG GP +C G + + + + E Sbjct: 321 PDVFDHTRPPAA------SRNLSFGLGPHSCAGQIISRAEATTVFAVLAERYERIELAEE 374 Query: 471 Q 471 Sbjct: 375 P 375 >3OFT-A nrPDB Length = 396 Score = 158 bits (398), Expect = 7e-39, Method: Composition-based stats. Identities = 68/401 (16%), Positives = 135/401 (33%), Gaps = 77/401 (19%) Query: 69 GKMWGTYEGQLPVLAITDPDVIRTV------LVKECYSVFTNRRSLGPVGFMKSAISLAE 122 G +W T G + A DV+R + L +C +V + ++ + Sbjct: 38 GLVWSTANGGHWIAA--RGDVVRELWGDAERLSSQCLAVTPGLGKVMQFIPLQQ-----D 90 Query: 123 DEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMD 182 E K R+ + S + + P + L+ +LR +G + D ++ Sbjct: 91 GAEHKAFRTPVMKGLASRFVVALEPKVQAVARKLMESLR---PRGSCDFVSDFAEILPLN 147 Query: 183 VITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFP 242 + F ID + + + + + V Sbjct: 148 I-----FLTLIDVPLEDRPRLRQLGVQLTRPDGS-------------------MTVEQLK 183 Query: 243 KDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIF 302 + ++L + + + D ++ E + + E Sbjct: 184 QAADDYLWPFIEKRMA-------QPGDDLFSRIL-----SEPVGGRPWTVDEARRMCRNL 231 Query: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362 +F G +T ++++ LA HP+ Q+ L++ + + + +E Sbjct: 232 LFGGLDTVAAMIGMVALHLARHPEDQRLLRE------------------RPDLIPAAADE 273 Query: 363 TLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422 +R +P + R DV+ +GV I KG +V +P+ + DP + PEE R +R Sbjct: 274 LMRRYPTV-AVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDR---- 328 Query: 423 KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 + P +T G G C+G A M + + L L Sbjct: 329 --GLAPIRHTTMGVGAHRCVGAGLARMEVIVFLREWLGGMP 367 >5EX8-A nrPDB Length = 424 Score = 158 bits (398), Expect = 7e-39, Method: Composition-based stats. Identities = 65/390 (16%), Positives = 126/390 (32%), Gaps = 72/390 (18%) Query: 85 TDPDVIRTVLVKECYSV--FTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKL 142 T D +R VL + +S + G ++ + E R+R ++ P F+ ++ Sbjct: 85 TGIDEVRQVLGSDKFSARLLYGGTAAGITW--PGFLTQYDPPEHTRLRRMVVPAFSHRRM 142 Query: 143 KEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDP 202 ++ P + Q +L G PV FG + D L P+D Sbjct: 143 QKFRPRVEQIVQ---DSLDTIESLGGPVDFVPHFGW-------AIATPATCDFLGIPRDD 192 Query: 203 FVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLN 262 + + L A K +K + MK+ Sbjct: 193 QADLARILL-----------------------ASRTDRSDKRRTAAGNKFMTYMKQHVAQ 229 Query: 263 DKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELA 322 ++ D ++ E+ A++D EL + + A + + +L+ + + Sbjct: 230 SRRGSGDDLFGIV-------GRENGDAITDAELTGVAAFVMGAAADQVARLLAAGAWLMV 282 Query: 323 THPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPV-AIRLERTCKKDV 381 P L++ + E + ++ET+R R +DV Sbjct: 283 EQPAQFALLRE------------------KPETVPEWLDETMRYLTTDEKTHPRVATQDV 324 Query: 382 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNC 441 I + G V A + P Y + +EF R + + FG G +C Sbjct: 325 RIGNQLVKAGDTVTCSLLAANR-PNYPSAEDEFDITR--------EKAEHLAFGHGIHHC 375 Query: 442 IGMRFALMNMKLALIRVLQNFSFKPCKETQ 471 +G A + K+++ + F + Q Sbjct: 376 LGRAMAELMFKVSIPALAHRFPTLRLADPQ 405 >5KYO-A nrPDB Length = 430 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 84/426 (19%), Positives = 143/426 (33%), Gaps = 76/426 (17%) Query: 71 MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL----AEDEEW 126 MW + G V D+ TV+ + F+N L P A L + E Sbjct: 75 MWTPHNGGHWVA--LRSDLAETVMSD--FERFSNHTVLVPKETAGEAYRLIPLSLDPPEH 130 Query: 127 KRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITG 186 + RSLL+ L+ + ++ L+ Sbjct: 131 RPFRSLLNENLGPKPLRPIEQVVTDLAVSLIE---------------------------- 162 Query: 187 TSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTI 246 G N F E + +D + L + + S+ D Sbjct: 163 ---GFRPKGRCNFTHEFAEQLPVRIFMRIVDLPVEDLPKLKHLADQYTRPDGSIPLDDVT 219 Query: 247 NFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAG 306 + + + ++R + K D + MI+ + + L+D+E I + G Sbjct: 220 KQFREYLRPVIEAR---RIKPGEDMISRMINGEV-----GGRPLTDIEAENICIQVLVGG 271 Query: 307 YETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL 366 +T ++L FT LA +++ + + +D + E R Sbjct: 272 LDTVVNMLGFTFSHLAKDHALRRAIAAD------------------PSLIDDALLEFFRR 313 Query: 367 FPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI 426 FPV R +D E GV + G MV+ PT + D +P EFR R +++ Sbjct: 314 FPVVSS-AREVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGRKARQ---- 368 Query: 427 DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEK 486 ++ FG G C G A M MK+ L + E PL+ + G++ K Sbjct: 369 ----HSTFGKGSHTCPGAHLARMEMKVVLREWFARIP-EFRIEDDAPLR-YSNGIVGSVK 422 Query: 487 PIVLKV 492 P VL+ Sbjct: 423 PFVLEW 428 >2IAG-A nrPDB Length = 482 Score = 152 bits (384), Expect = 3e-37, Method: Composition-based stats. Identities = 91/503 (18%), Positives = 178/503 (35%), Gaps = 68/503 (13%) Query: 35 RLGIPGPTPL-----PLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDV 89 R PG PL P LG L + + F T +K+G ++ G V + DP Sbjct: 1 RTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHS 60 Query: 90 IRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSG--KLKEMFP 147 V+ + + F AI L E RI + P ++ K + Sbjct: 61 YDAVVWEPRTR----------LDFHAYAIFLME-----RIFDVQLPHYSPSDEKARMKLT 105 Query: 148 IIAQYGDVLVRNLRREAEKGKPVTLKDIFGAY----SMDVITGTSFGVNIDSLNNPQDPF 203 ++ + L + + + +D +L + Sbjct: 106 LLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALP 165 Query: 204 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTI----NFLSKSVNRMKKS 259 + +F + L P ++S+ KD + + L K ++ + + Sbjct: 166 RTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLA 225 Query: 260 RLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLY 319 R + K +L + + S+E + A ++ ++A + L Sbjct: 226 RRAHRSKWLESYLLHLEEMGVSEEMQ----------ARALVLQLWATQGNMGPAAFWLLL 275 Query: 320 ELATHPDVQQKLQKEIDAVLPNKAPPTYDA-------VVQMEYLDMVVNETLRLFPVAIR 372 L +P+ ++ E++++L P + LD V++E+LRL A Sbjct: 276 FLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPF 334 Query: 373 LERTCKKDVEI-----NGVFIPKGSMVVI-PTYALHHDPKYWTEPEEFRPERFSKKKDSI 426 + R D+ + + +G +++ P + DP+ +T+PE F+ RF S Sbjct: 335 ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSE 394 Query: 427 DPYIY----------TPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK-ETQIP-- 473 Y P+G G +C+G +A+ ++K + VL + + + +IP Sbjct: 395 KKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEF 454 Query: 474 -LKLDTQGLLQPEKPIVLKVDSR 495 L GL+QPE + ++ R Sbjct: 455 DLSRYGFGLMQPEHDVPVRYRIR 477 >3NV6-A nrPDB Length = 452 Score = 151 bits (381), Expect = 7e-37, Method: Composition-based stats. Identities = 74/425 (17%), Positives = 140/425 (32%), Gaps = 69/425 (16%) Query: 71 MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL---AEDEEWK 127 +W + G + T+ D ++ V F++ P + + + E Sbjct: 90 IWTPFTGGHWIA--TNGDTVKEVYSDPTR--FSSEVIFLPKEAGEKYQMVPTKMDPPEHT 145 Query: 128 RIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGT 187 R L K++++ + + L+ + E ++F + Sbjct: 146 PYRKALDKGLNLAKIRKVEDKVREVASSLIDSFAARGECDFAAEYAELFPVH-------- 197 Query: 188 SFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTIN 247 F D E ++ + P ++ L + N Sbjct: 198 VFMALADLPLEDIPVLSEYARQMTRPEGNTPEEMATDL-----------------EAGNN 240 Query: 248 FLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGY 307 V+ + ++R+ D + LM++S+ + E +H L Sbjct: 241 GFYAYVDPIIRARVGG---DGDDLITLMVNSEINGERIAHDKAQGLISLLLLGG-----L 292 Query: 308 ETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF 367 +T + LSF + LA HP++ +L+ + ++ E R F Sbjct: 293 DTVVNFLSFFMIHLARHPELVAELRSDPLKLMRGA------------------EEMFRRF 334 Query: 368 PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID 427 PV R KD E GVF+ +G M+++PT D EP + R Sbjct: 335 PVV-SEARMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSR--------R 385 Query: 428 PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKP 487 ++ FG GP C GM A M + + L L+ KE + P+ G++ + Sbjct: 386 SISHSTFGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPI--YHSGIVAAVEN 443 Query: 488 IVLKV 492 + L Sbjct: 444 VPLVW 448 >4FB2-A nrPDB Length = 398 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 68/440 (15%), Positives = 140/440 (31%), Gaps = 79/440 (17%) Query: 54 RQGLWKFDTECYKKY--GKM-WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGP 110 F + + W G V+A I+ V+ + F+N+ P Sbjct: 18 DGTPHAFFEALRDEAETTPIGWSEAYGGHWVVA--GYKEIQAVI--QNTKAFSNKGVTFP 73 Query: 111 ---VGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKG 167 G + ++ +D K+ R L++ F+ + Q + L+ E Sbjct: 74 RYETGEFELMMAGQDDPVHKKYRQLVAKPFSPEATDLFTEQLRQSTNDLIDARIELGEGD 133 Query: 168 KPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFP 227 L + A +T G+ + + + + Sbjct: 134 AATWLANEIPA----RLTAILLGLPPEDGD------------------------TYRRWV 165 Query: 228 FLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESH 287 + E P++ ++ V + + D + +I S+ E+ Sbjct: 166 WAITHVE------NPEEGAEIFAELVAHARTLIAERRTNPGNDIMSRVIMSKIDGES--- 216 Query: 288 KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTY 347 LS+ +L I + G + T+ LS + LA +++++L Sbjct: 217 --LSEDDLIGFFTILLLGGIDNTARFLSSVFWRLAWDIELRRRL---------------- 258 Query: 348 DAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKY 407 + E + V+E LR + A+ + R ++V + + + G ++ D Sbjct: 259 --IAHPELIPNAVDELLRFYGPAM-VGRLVTQEVTVGDITMKPGQTAMLWFPIASRDRSA 315 Query: 408 WTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN---FSF 464 + P+ ER P + G G C+G + ++A+ L+ FS Sbjct: 316 FDSPDNIVIER--------TPNRHLSLGHGIHRCLGAHLIRVEARVAITEFLKRIPEFSL 367 Query: 465 KPCKETQIPLKLDTQGLLQP 484 P KE + + L P Sbjct: 368 DPNKECEWLMGQVAGMLHVP 387 >1WIY-A nrPDB Length = 389 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 83/466 (17%), Positives = 158/466 (33%), Gaps = 79/466 (16%) Query: 33 FKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRT 92 KRL + P + +Q E + + +++ + P+ I DP+ + Sbjct: 1 MKRLSLREAWPY-----LKDLQQDPLAVLLEWGRAHPRLF-LPLPRFPLALIFDPEGVEG 54 Query: 93 VLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQY 152 L+ E + T + + ++ + WK R L F ++ + + Sbjct: 55 ALLAEGTTKATFQYRALSRLTGRGLLTDW-GKSWKEARKALKDPFLPKSVRGYREAMEEE 113 Query: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 212 R G+ L A S+ ++ FG + E K L Sbjct: 114 AWAFFGEWR-----GEERDLDHEMLALSLRLLGRALFGKPLS------PSLAEHALKALD 162 Query: 213 FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFL 272 +L F +L+ + + ++ + + R Sbjct: 163 RIMAQTRSPLALLDLAAEARFRKDRGALYREAEALIVHPPLSHLPRERA----------- 211 Query: 273 QLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQ 332 ++++ + AG+ET +S L+++ L+ PD Q+++ Sbjct: 212 -----------------------LSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRV- 247 Query: 333 KEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGS 392 E E LRL+P A L R ++ + + +P+G+ Sbjct: 248 -----------------AESEEAALAAFQEALRLYPPAWILTRRLERPLLLGEDRLPQGT 290 Query: 393 MVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMK 452 +V+ Y Y+ E E F+PERF ++ + Y PFG G R C+G FAL+ Sbjct: 291 TLVLSPYVTQR--LYFPEGEAFQPERFLAERGTPSG-RYFPFGLGQRLCLGRDFALLEGP 347 Query: 453 LALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGT 498 + L + F P ++ Q L+PE + R+G Sbjct: 348 IVLRAFFRRFRLDPLPFPRV----LAQVTLRPEGGLP--ARPREGV 387 >6G5O-A nrPDB Length = 399 Score = 144 bits (364), Expect = 7e-35, Method: Composition-based stats. Identities = 66/430 (15%), Positives = 132/430 (30%), Gaps = 81/430 (18%) Query: 63 ECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVF-----TNRRSLGPVGFMKSA 117 K YG+ + PV + +R Y F R + ++ Sbjct: 14 RESKGYGE---MNDQDDPVTMLLRHKDVRKSAHN--YKTFQSGAVPGRIVIPSEVDIRDT 68 Query: 118 ISL---AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKD 174 + + R+++ P F K + + + KG Sbjct: 69 RQIPFEVDPPVHGVYRAIVEPWF---KRPLQAEYQEKLTAQISEIVEETLLKG------- 118 Query: 175 IFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFE 234 S++V+T + + + L P S + T VF Sbjct: 119 -----SVEVVTDFALRLQ---------------SRALTLLLNTPFSESETWISWGTHVFR 158 Query: 235 ALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLE 294 + +L D N L ++ + D ++++S+ + L+ E Sbjct: 159 SEGEALDG-DKANILYHYIDEQIDR---ASENPGDDMYSVLLNSE-----FEGRKLTKEE 209 Query: 295 LAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQME 354 + ++ G +T + ++ ++ LA HP+ ++L+KE E Sbjct: 210 VKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKE------------------PE 251 Query: 355 YLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEF 414 V E +R F ++ R +D + + S + + + + D + P E Sbjct: 252 ITGRAVEEMIRYFSPLTQMGRVVTEDTHVCEHAVKADSRISLCWASANRDAAVFENPNEI 311 Query: 415 RPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN---FSFKPCKETQ 471 +R + FG NC+G A +K+ L + Q F KE Sbjct: 312 VLDRKV--------NPHVGFGFSHHNCLGATHARQILKILLQTLAQKVASFEILDYKENI 363 Query: 472 IPLKLDTQGL 481 L + + Sbjct: 364 EDLDHFQRKV 373 >2QBO-A nrPDB Length = 421 Score = 144 bits (364), Expect = 7e-35, Method: Composition-based stats. Identities = 68/413 (16%), Positives = 139/413 (33%), Gaps = 79/413 (19%) Query: 88 DVIRTVLVKECYSVFTNRRSLGPVGFMK---SAISLAEDEEWKRIRSLLSPTFTSGKLKE 144 +IR E Y F++ P + + + E ++ R+L + + + Sbjct: 70 QLIREAY--EDYRHFSSECPFIPREAGEAYDFIPTSMDPPEQRQFRALANQVVGMPVVDK 127 Query: 145 MFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFV 204 + I + L+ +LR +G+ +D + + + + G+ + + + Sbjct: 128 LENRIQELACSLIESLR---PQGQCNFTEDYAEPFPIRIFMLLA-GLPEEDIPH------ 177 Query: 205 ESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDK 264 +LT + S+ + L + + + R + Sbjct: 178 ---------------------LKYLTDQMTRPDGSMTFAEAKEALYDYLIPIIEQR---R 213 Query: 265 QKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATH 324 QK D + ++ + Q + + ++ E + + G +T + LSF++ LA Sbjct: 214 QKPGTDAISIVANGQV-----NGRPITSDEAKRMCGLLLVVGLDTVVNFLSFSMEFLAKS 268 Query: 325 PDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEIN 384 P+ +Q+L + + E + E LR F + R D E + Sbjct: 269 PEHRQEL------------------IERPERIPAACEELLRRFS-LVADGRILTSDYEFH 309 Query: 385 GVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGM 444 GV + KG +++P D + P R +T FG G C+G Sbjct: 310 GVQLKKGDQILLPQMLSGLDERENACPMHVDFSR--------QKVSHTTFGHGSHLCLGQ 361 Query: 445 RFALMNMKLALIRVLQN---FSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDS 494 A + + L L FS P + Q G++ + + L D Sbjct: 362 HLARREIIVTLKEWLTRIPDFSIAPGAQIQ-----HKSGIVSGVQALPLVWDP 409 >2IJ7-A nrPDB Length = 396 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 55/348 (15%), Positives = 114/348 (32%), Gaps = 66/348 (18%) Query: 129 IRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTS 188 +R + T + + + L+ NL E G P L++ F + Sbjct: 94 LRKAVMKAITPKA-PGLEQFLRDTANSLLDNLITE---GAPADLRNDFADPLATALHCKV 149 Query: 189 FGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINF 248 G+ + P + F++ + I + Sbjct: 150 LGIPQEDG---------------------PKLFRSLSIAFMSSADPIPAAKINWDRDIEY 188 Query: 249 LSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYE 308 ++ + ++ LM + ++ ++ +SD A + F AG Sbjct: 189 MAGIL------------ENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVI 236 Query: 309 TTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL-F 367 +T S L+ L L P ++ L + + E + V E LR+ Sbjct: 237 STGSFLTTALISLIQRPQLRNLLHE------------------KPELIPAGVEELLRINL 278 Query: 368 PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID 427 A L R D+++ V + KG +V++ + DP+++ P +R + Sbjct: 279 SFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRP-------N 331 Query: 428 PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK 475 P + FG G C G + ++ + +L+ P + +P+ Sbjct: 332 PTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKM---PGVDLAVPID 376 >6FYJ-A nrPDB Length = 421 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 66/409 (16%), Positives = 140/409 (34%), Gaps = 61/409 (14%) Query: 70 KMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGP-----VGFMKSAISLAEDE 124 ++ T + + + E + R+ P F K+ + + + Sbjct: 39 DIFETRLLGKKAICMGGKEAAEIFYDTEKF----KRKDAAPNRVVQTLFGKNGVQALDGQ 94 Query: 125 EWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVI 184 K + + + +L+++ I + ++ V + V L + Sbjct: 95 THKHRKEMFMSIMSPDELEKLTDITKKQWEIAVDKWEQMD----KVILYEEAKEIMCRTA 150 Query: 185 TGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKD 244 + GV + E + G + ++ L +L Sbjct: 151 CQWA-GVPVQEN--------EVKRLTKNLGAMFESAAAVGLKHWLGRHARNYEEI----- 196 Query: 245 TINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF 304 ++ + ++R++ ++N + L + S + L D E AA +I I Sbjct: 197 ---WIEELIDRVRDGKVNPPENTTL--------HKFSWYRDLEGNLLDTETAAVEVINIL 245 Query: 305 AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETL 364 + ++F L +P+ ++KL+ +Y M V E Sbjct: 246 RPIVAIAIFINFIALALHHYPEEKEKLKS-----------------GDKKYSQMFVQEVR 288 Query: 365 RLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKD 424 R +P + KKD G +G++ ++ Y +HDP+ W P+ F P+RF+K + Sbjct: 289 RFYPFFPFVVALVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEG 348 Query: 425 SIDPYIYTPFGTGP----RNCIGMRFALMNMKLALIRVLQNFSFKPCKE 469 S P+ + P G G C G + MK++L + ++ + Sbjct: 349 S--PFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYEVPDQ 395 >5D3U-A nrPDB Length = 427 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 56/351 (15%), Positives = 106/351 (30%), Gaps = 53/351 (15%) Query: 113 FMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTL 172 + K+ + + +R + FT + ++ + LV ++ + Sbjct: 103 WTKNVVMYTDPPLHDALRRSVRAGFTRAAHQHYDQVLQKVAHDLVASI---PAGATEIDA 159 Query: 173 KDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPV 232 A +FGV + L ++ P PV Sbjct: 160 VPALAAELPVRSAVHAFGVPEEDLGFLIPRV--------------NTIMTYFSGPKDQPV 205 Query: 233 FEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSD 292 + + + D + S+ + M+ L D + + + TE+ + Sbjct: 206 TQEI-ILEKLTDLHTYASELLQGMRGKVLP-------DTVIARLAAAQDGLTETTPEQTV 257 Query: 293 LELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQ 352 +LA I TT LS A +P ++ + V Sbjct: 258 HQLALVFIALFAP---TTPGSLSSGTLAFARNPRQVERFLADQACV-------------- 300 Query: 353 MEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPE 412 D NE LR R KDVE+ GV I G + + + + D + P Sbjct: 301 ----DNTANEVLRYNASNQFTWRVAAKDVEMGGVRIEAGQTLALFLGSANRDANMFERPN 356 Query: 413 EFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463 +F +R + + FG G C+ + + +K + +L F Sbjct: 357 DFDLDRP-------NSARHLSFGQGVHACLAAQLISLQLKWFYVALLNRFP 400 >5M0P-A nrPDB Length = 428 Score = 134 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 71/437 (16%), Positives = 140/437 (32%), Gaps = 54/437 (12%) Query: 47 LGNVLSYRQGLWKFDTECYKKYG-KMWGTY-EGQLPVLAITDPDVIRTVLVKECYSVFTN 104 L N L + + + T + ++ T G P + +T + + Sbjct: 16 LDNTLKVLKQGYLYTTNQRNRLNTSVFQTKALGGKPFVVVTGKEGAEMFYNNDVVQREGM 75 Query: 105 RRS-LGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRRE 163 + K AI + ++ ++L T G L + + L Sbjct: 76 LPKRIVNTLAGKGAIHTVDGKKHVDRKALFMSLMTEGNLN----YVRELTRTL---WHAN 128 Query: 164 AEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSI 223 ++ + + +I Y ++ T G + P + + + I Sbjct: 129 TQRMESMDEVNI---YRESIVLLTKVGTRWAGVQAPPEDIER---------IATDMDIMI 176 Query: 224 ILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKE 283 F L F+ S + + + ++ ++R + L ++ Sbjct: 177 DSFRALGGAFKGYKASKEARRRVEDWLE--EQIIETRKGNIHPPEGTALYEFAHWEDYLG 234 Query: 284 TESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKA 343 ++L I + +SF L+ + +P ++K++ E D Sbjct: 235 NPMDSRTCAIDLMNTFRPLIA-----INRFVSFGLHAMNENPITREKIKSEPD------- 282 Query: 344 PPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHH 403 Y E R +P L K D++ GV IP G + + Y H Sbjct: 283 -----------YAYKFAQEVRRYYPFVPFLPGKAKVDIDFQGVTIPAGVGLALDVYGTTH 331 Query: 404 DPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGP----RNCIGMRFALMNMKLALIRVL 459 D W +P EFRPERF S P+ P G G C G ++ M+ + Sbjct: 332 DESLWDDPNEFRPERFETWDGS--PFDLIPQGGGDYWTNHRCAGEWITVIIMEETMKYFA 389 Query: 460 QNFSFK-PCKETQIPLK 475 + ++ P ++ ++ L Sbjct: 390 EKITYDVPEQDLEVDLN 406 >2ZQJ-A nrPDB Length = 417 Score = 132 bits (331), Expect = 5e-31, Method: Composition-based stats. Identities = 67/456 (14%), Positives = 149/456 (32%), Gaps = 56/456 (12%) Query: 47 LGNVLSYRQGLWKFDTECYKKYG-KMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNR 105 L N L+ + + F ++Y ++ + +T + + + + Sbjct: 11 LDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAKVFYDTDRFQRQNAL 70 Query: 106 RS-LGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREA 164 + F +AI + R +L + + P + +++ + Sbjct: 71 PKRVQKSLFGVNAIQGMDGSAHI-HRKMLFLSLMTP------PHQKRLAELMTEEWKAAV 123 Query: 165 EKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSII 224 + + +F + +++ + E ++ F + F ++ Sbjct: 124 TRWEKADEVVLFEE-AKEILCRVAC-----YWAGVPLKETEVKERADDFIDMVDAFGAVG 177 Query: 225 LFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKET 284 + + ++ I + ++ +R + L M + Sbjct: 178 PRHW-----KGRRARPRAEEWIEVM------IEDARAGLLKTTSGTALHEMAFHTQEDGS 226 Query: 285 ESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAP 344 + ++ +EL + S L F+ L HP ++ L+ Sbjct: 227 QLDSRMAAIELINVLRPIVA-----ISYFLVFSALALHEHPKYKEWLRSGNSRER----- 276 Query: 345 PTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHD 404 +M V E R +P L KKD N KG+ V++ Y +HD Sbjct: 277 ------------EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHD 324 Query: 405 PKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGP----RNCIGMRFALMNMKLALIRVLQ 460 P+ W P+EFRPERF+++++++ + P G G C G + MK +L ++ Sbjct: 325 PRLWDHPDEFRPERFAEREENL--FDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVH 382 Query: 461 NFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRD 496 + +++ + PE V+ R Sbjct: 383 QIEYDVPEQSLHY--SLARMPSLPESGFVMSGIRRK 416 >4C9K-A nrPDB Length = 421 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 67/472 (14%), Positives = 151/472 (31%), Gaps = 87/472 (18%) Query: 41 PTPLPLLGNVLS---------YRQGLWKFDTECYKKYGK--MWGTYEGQLPVLAITDPDV 89 P P + G+++ QG + + +W + G + Sbjct: 16 PPPH-VPGHLIREIDAYDLDGLEQGFHEAWKRVQQPDTPPLVWTPFTGGHWI-------A 67 Query: 90 IRTVLVKECY---SVFTNRRSLGPVGFMKS---AISLAEDEEWKRIRSLLSPTFTSGKLK 143 R L+ E Y F++R P ++ + + E R + +++ Sbjct: 68 TRGTLIDEIYRSPERFSSRVIWVPREAGEAYDMVPTKLDPPEHTPYRKAIDKGLNLAEIR 127 Query: 144 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF 203 ++ I ++ A++G + + + V + G+ ++ Sbjct: 128 KLEDQIRTIAVEIIEGF---ADRGHCEFGSEFSTVFPVRVFLALA-GLPVEDATKLGLLA 183 Query: 204 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND 263 E T+ TP + ++ K +++ + + Sbjct: 184 NEMTR-----------------PSGNTPEEQGRSLEAANKGFFEYVAPIIAARRG----- 221 Query: 264 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT 323 D + +++ + K + D + + G +T + L F + L+ Sbjct: 222 --GSGTDLITRILNVEID-----GKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSR 274 Query: 324 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 383 HP+ ++++E L V E R F V R D+E Sbjct: 275 HPETVAEMRREPLK------------------LQRGVEELFRRFAVV-SDARYVVSDMEF 315 Query: 384 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG 443 +G + +G ++++PT D ++ +P R ++ F GP C G Sbjct: 316 HGTMLKEGDLILLPTALHGLDDRHHDDPMTVDLSRRDV--------THSTFAQGPHRCAG 367 Query: 444 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495 M A + + + L L K+ +P+ G++ + I L+ + + Sbjct: 368 MHLARLEVTVMLQEWLARIPEFRLKDRAVPI--YHSGIVAAVENIPLEWEPQ 417 >5YHJ-A nrPDB Length = 413 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 71/426 (16%), Positives = 138/426 (32%), Gaps = 70/426 (16%) Query: 71 MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGP-----VGFMKSAISLAEDEE 125 ++ + V+ + + ++ R+ P F + + + E Sbjct: 36 IFESRLLGERVICLGGEEAAEVFYDANKFT----RQDAAPKRLLKTLFGEGGVQTLDGSE 91 Query: 126 WKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVIT 185 + + T I + + R + G+ + L DI M + Sbjct: 92 HTHRKQMFMSLMT-------KENIDRLLRLTYREWNQIERMGEEIVLYDIAQEVLMKAVC 144 Query: 186 GTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDT 245 S GV + E + + G L P + + + Sbjct: 145 EWS-GVPL--AKEEVGKRTEEMRLLFESGTS------------LGPTYLQGRKARSSAEV 189 Query: 246 INFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFA 305 ++ + V ++ +RL + L + S + L E+ A ++ I Sbjct: 190 --WIRQMVKEVRSNRLLPNEHTAL--------YEFSWHRDESGELLPEEVVAVEVLNILR 239 Query: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR 365 S + FT+ L PDV++++++ V + E V E R Sbjct: 240 PTVAISVYVLFTVLALHQFPDVKEQVER--------------GEVSKTE----FVQEVRR 281 Query: 366 LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDS 425 +P K D E +G P+G++ ++ Y +HD WTEP+ F P RF K+S Sbjct: 282 FYPFFPVAAARVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRFKDWKES 341 Query: 426 IDPYIYTPFGTGP----RNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGL 481 P+ + P G G C G + + + + +++ P L + Sbjct: 342 --PFNFIPQGGGDVDFGHRCAGEHVTIAILAQVIELFTKEYAYTVP-----PQDLSYSFV 394 Query: 482 LQPEKP 487 P P Sbjct: 395 DMPSLP 400 >6G71-A nrPDB Length = 405 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 62/436 (14%), Positives = 129/436 (29%), Gaps = 69/436 (15%) Query: 41 PTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYS 100 PT + ++ Q + + + E + IT + V + + Sbjct: 9 PTADWV--HLADLYQNPFPIFERLRSE-SPVAWVPEAGRYL--ITSYSGVLAADVDQT-T 62 Query: 101 VFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKE-MFPIIAQYGDVLVRN 159 N + + M ++ +D + + R P+ G +K+ A+ D + Sbjct: 63 FSANEKKSLMLRAMGHSMLRKDDPDHQVERRAWQPSLKPGTVKKVWKQKFAENADRYLDA 122 Query: 160 LRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPL 219 + G F A + N E+ + + L Sbjct: 123 YI---DAGSGSDFMQGFAA-------------PFVAENLRALIGFENASEADLQRWSQTL 166 Query: 220 FLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQ 279 +P V+ S D I+ + + + R D L ++ S Sbjct: 167 IDGAGNYPDDPDVWAKAKQS---SDEIDAALEEMIQWHSGRPGDS------LLSYLLRS- 216 Query: 280 NSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL 339 + + + + + I G VL + L + + + ++ Sbjct: 217 ------ADYQMPLESIRSNIKMTIGGGLNEPRDVLGVSTLALLSSSKQLELVLRD----- 265 Query: 340 PNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTY 399 + V E++R + R D E++G FIP+G+ + + Sbjct: 266 -------------PKLWGAVFEESIRWVAPIGMVPRQTVVDTELDGYFIPRGAKLGLCIL 312 Query: 400 ALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMK-LALIRV 458 + + D W++P+ F ER + FG G C+G A + + L + Sbjct: 313 SANRDRSVWSDPDRFDIER--------GSEAHLAFGKGVHVCLGAWAARSQVADVGLPAL 364 Query: 459 LQN---FSFKPCKETQ 471 P +E Sbjct: 365 FSRLKGLRLDPNQEAT 380 >5OMS-A nrPDB Length = 409 Score = 127 bits (320), Expect = 8e-30, Method: Composition-based stats. Identities = 53/413 (12%), Positives = 116/413 (28%), Gaps = 56/413 (13%) Query: 50 VLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLG 109 + + ++ + + G + +V R V + G Sbjct: 19 MTQLERNPYEVYERLRAEAPLAFVPVLGS---YVASTAEVCREVATSPDFE--AVITPAG 73 Query: 110 PVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEM-FPIIAQYGDVLVRNLRREAEKGK 168 F AI + +RS++ P ++ ++ + + Sbjct: 74 GRTFGHPAIIGVNGDIHADLRSMVEPALQPAEVDRWIDDLVRPIARRYLERFENDGH--- 130 Query: 169 PVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPF 228 A + ++ S G + D E K + F + F Sbjct: 131 -----AELVAQYCEPVSVRSLGDLLGLQEVDSDKLREWFAKLNR-SFTNAAVDENGEFAN 184 Query: 229 LTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHK 288 E + + +++ + + H L + Sbjct: 185 PEGFAEG---DQAKAEIRAVVDPLIDKWIEHPDDSAISHWL-----------HDGMPPGQ 230 Query: 289 ALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYD 348 + +++ + ++ TL L + P+ +++ + Sbjct: 231 TRDREYIYPTIYVYLLGAMQEPGHGMASTLVGLFSRPEQLEEVVDD-------------- 276 Query: 349 AVVQMEYLDMVVNETLRLFPVAI-RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKY 407 + + E LR R K V I GV +P G+ V++ + +HD Sbjct: 277 ----PTLIPRAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLSYGSANHDTGK 332 Query: 408 WTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQ 460 + P ++ R P + FG G C G+ FA M++AL + + Sbjct: 333 YEAPSQYDLHRP--------PLPHLAFGAGNHACAGIYFANHVMRIALEELFE 377 >3AWQ-A nrPDB Length = 415 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 67/426 (15%), Positives = 126/426 (29%), Gaps = 55/426 (12%) Query: 50 VLSYRQGLWKFDTECYKKYG-KMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRR-S 107 LS ++F + ++ G + + + + + Sbjct: 13 TLSLLADPYRFISRQCQRLGANAFESRFLLKKTNCLKGAKAAEIFYDTTRFEREGAMPVA 72 Query: 108 LGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKG 167 + F + + + E + + + T +++ + + V R KG Sbjct: 73 IQKTLFGQGGVQGLDGETHRHRKQMFMGLMTPERVRALAQLFEAEWRRAVPGWTR---KG 129 Query: 168 KPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFP 227 + V ++ + V + D N G P L L Sbjct: 130 EIVFYDELHEPLTRAVCAWAGVPLPDDEAGNRAGELRALFDAA---GSASPRHLWSRLA- 185 Query: 228 FLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESH 287 V + K I + D H Sbjct: 186 -------RRRVDAWAKRIIEGIRAGSIGSGSGTAAYAIAWHRD---------------RH 223 Query: 288 KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTY 347 L +AA ++ + + ++F + L T ++ L Sbjct: 224 DDLLSPHVAAVELVNVLRPTVAIAVYITFVAHALQTCSGIRAAL---------------- 267 Query: 348 DAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKY 407 V Q +Y ++ V E R +P + +D E G+ P+G VV+ Y +HD Sbjct: 268 --VQQPDYAELFVQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGSNHDAAT 325 Query: 408 WTEPEEFRPERFSKKKDSIDPYIYTPFGTGP----RNCIGMRFALMNMKLALIRVLQNFS 463 W +P+EFRPERF + D + + P G G C G L MK+A ++ Sbjct: 326 WADPQEFRPERFRAWDE--DSFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMR 383 Query: 464 FKPCKE 469 + + Sbjct: 384 YDVPDQ 389 >2RCM-A nrPDB Length = 495 Score = 107 bits (268), Expect = 8e-24, Method: Composition-based stats. Identities = 85/485 (17%), Positives = 148/485 (30%), Gaps = 81/485 (16%) Query: 36 LGIPGPTPLPLLGNVLS-----YRQGLWKFDTECYKKYGK-MWGT------YEGQLP-VL 82 IPG LP++G + Y QG +F +KY ++ + + P V+ Sbjct: 28 RNIPGNYGLPIVGPIKDRWDYFYDQGAEEFFKSRIRKYNSTVYRVNMPPGAFIAENPQVV 87 Query: 83 AITDPDV---IRTVLVKECYSVFTN--RRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTF 137 A+ D + V E + T S G + L E L Sbjct: 88 ALLDGKSFPVLFDVDKVEKKDLLTGTYMPSTELTGGYRILSYLDPSEPKHEKLKNLLFFL 147 Query: 138 TSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVN--IDS 195 +FP L +L +E + + + +G N Sbjct: 148 LKSSRNRIFPEFQATYSELFDSLEKELSLKGKADFGGSSDGTAFNFLARAFYGTNPADTK 207 Query: 196 LNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFL-TPVFEALNVSLFPKDTINFLSKSVN 254 L + F L +I P + T V + F +S Sbjct: 208 LKADAPGLITKWVLFNLHPLLSIGLPRVIEEPLIHTFSLPPALVKSDYQRLYEFFLESAG 267 Query: 255 RMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVL 314 +++++ +S E +FA + Sbjct: 268 E------------------ILVEADKLG-------ISREEATHN---LLFA-----TCFN 294 Query: 315 SFTLYELATHPD-----------VQQKLQKEIDAVL-PNKAPPTYDAVVQMEYLDMVVNE 362 ++ ++ P+ V +L +EI +V+ N T A+ +ME VV E Sbjct: 295 TWGGMKIL-FPNMVKRIGRAGHQVHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYE 353 Query: 363 TLRLFPVAIRLERTCKKDVEINGV----FIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418 LR P KKD+ I + G M+ DPK + +EF PER Sbjct: 354 CLRFEPPVTAQYGRAKKDLVIESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPER 413 Query: 419 FSKKKDSIDPYIYTPFGTGP---------RNCIGMRFALMNMKLALIRVLQNFSFKPCKE 469 F ++ + + GP + C G F ++ +L +I + + + + Sbjct: 414 FVGEEGE-KLLRHVLWSNGPETETPTVGNKQCAGKDFVVLVARLFVIEIFRRYDSFDIEV 472 Query: 470 TQIPL 474 PL Sbjct: 473 GTSPL 477 >3DBM-A nrPDB Length = 473 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 79/482 (16%), Positives = 153/482 (31%), Gaps = 74/482 (15%) Query: 36 LGIPGPTPLPLLGNV---LSY-----RQGLWKFDTECYKKYGKMWGTYEGQLPVL----- 82 IPG +P + L Y + + F + K ++ P + Sbjct: 9 REIPGSYGIPFFQPIKDRLEYFYGTGGRDEY-FRSRMQKYQSTVFRANMPPGPFVSSNPK 67 Query: 83 --AITDPDV---IRTVLVKECYSVFTN--RRSLGPVGFMKSAISLAED-EEWKRIRSL-- 132 + D + V E +FT S G + L ++++L Sbjct: 68 VIVLLDAKSFPILFDVSKVEKKDLFTGTYMPSTKLTGGYRVLSYLDPSEPRHAQLKNLLF 127 Query: 133 -LSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGV 191 + ++ + + + L L E K D+ + + F Sbjct: 128 FMLKNSSNRVIPQFETTYTE----LFEGLEAELAKNGKAAFNDVGEQAAFRFLGRAYFNS 183 Query: 192 NIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSK 251 N + K G P +S + L P + L + F ++ + + Sbjct: 184 NPEET---------------KLGTSAPTLISSWVLFNLAPTLD-LGLPWFLQEPLLHTFR 227 Query: 252 SVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYE--- 308 + KS N + +++ +A+ + F G + Sbjct: 228 LPAFLIKSTYNKLYDYFQSVATPVMEQAEKLGVPKDEAV--HNILFAVCFNTFGGVKILF 285 Query: 309 -TTSSVLSFTLYELATHPDVQQKLQKEIDAVLPN--KAPPTYDAVVQMEYLDMVVNETLR 365 T + L T +L +EI + + T +A+ QM VV E+LR Sbjct: 286 PNTLKWIGLAGENLHT------QLAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLR 339 Query: 366 LFPVAIRLERTCKKDVEINGV----FIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421 + P K + I + KG M+ DPK + PEE+ P+RF Sbjct: 340 IEPPVPPQYGKAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVG 399 Query: 422 KKDSIDPYIYTPFGTGP---------RNCIGMRFALMNMKLALIRVLQNFSFKPCKETQI 472 +++ Y++ + GP + C G F ++ +L +I + + + + + Sbjct: 400 DGEALLKYVW--WSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYDSFEIELGES 457 Query: 473 PL 474 PL Sbjct: 458 PL 459 >2YJN-B nrPDB Length = 381 Score = 69.8 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 26/129 (20%), Positives = 49/129 (37%), Gaps = 18/129 (13%) Query: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362 +FAG E T++ + + ++ P + +++ + A V E Sbjct: 220 LFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAAA------------------QRTVAE 261 Query: 363 TLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 422 LRL P RT +V + I +G VV+ A + DP+ + EP+ +R Sbjct: 262 VLRLHPALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDRPDAD 321 Query: 423 KDSIDPYIY 431 + + Sbjct: 322 RALSAHRGH 330 >4YXC-B nrPDB Length = 227 Score = 32.1 bits (71), Expect = 0.65, Method: Composition-based stats. Identities = 14/48 (29%), Positives = 24/48 (50%), Gaps = 3/48 (6%) Query: 352 QMEYLDMVVNETLRLF-PVAIRLERTCKK--DVEINGVFIPKGSMVVI 396 ++ M + E LRL + L+ + D+ ING I +G +VV+ Sbjct: 157 ELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 204 >2FA5-A nrPDB Length = 162 Score = 31.7 bits (70), Expect = 0.73, Method: Composition-based stats. Identities = 20/134 (14%), Positives = 40/134 (29%), Gaps = 19/134 (14%) Query: 36 LGIPGPTPLPLLGNVLSYRQGLWKFDT-----ECYKKYGKMWGTYEGQLPVLAITDPDVI 90 L P P+P P+L N+ + + K YG +G + V+ I Sbjct: 4 LDTPTPSPHPVLLNLEQFLPYRLSVLSNRISGNIAKVYGDRYGMAIPEWRVITIL----- 58 Query: 91 RTVLVKECYSVFTNRRSLGPVGFMKSAI-----SLAEDEEWKRIRSLLSPTFTSGKLKEM 145 + S ++R ++ V ++ E R + + Sbjct: 59 -ALYPGSSASEVSDRTAMDKVAVSRAVARLLERGFIRRETHGDDRRRSMLALSPAGRQVY 117 Query: 146 F---PIIAQYGDVL 156 P++ + L Sbjct: 118 ETVAPLVNEMEQRL 131 >5DJQ-C nrPDB Length = 311 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 14/75 (18%), Positives = 27/75 (36%), Gaps = 5/75 (6%) Query: 21 LLYLYGTRTHGLFKRLGIPGPTPL----PLLGNVLSYRQGLWKFDTECYKKYGKMWGTYE 76 LL++ GT G+ + PG P + + + + +KYG ++ Y Sbjct: 60 LLFI-GTLVFGILYLVLYPGLGNWKGVLPGYEGGWTQEKQWEREVAQADEKYGPIFAKYA 118 Query: 77 GQLPVLAITDPDVIR 91 DP ++ Sbjct: 119 AMSVEEVAQDPQAVK 133 >4M2J-A nrPDB Length = 406 Score = 30.9 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 6/43 (13%), Positives = 15/43 (34%) Query: 327 VQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPV 369 V ++ + D ++ +A + + E +R P Sbjct: 285 VAERAVRHADELIGARAAEARHNLAHLTGWMAAHEELVRWTPP 327 >4YXB-D nrPDB Length = 80 Score = 30.5 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 14/48 (29%), Positives = 24/48 (50%), Gaps = 3/48 (6%) Query: 352 QMEYLDMVVNETLRLF-PVAIRLERTCKK--DVEINGVFIPKGSMVVI 396 ++ M + E LRL + L+ + D+ ING I +G +VV+ Sbjct: 10 ELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 57 >3EN1-A nrPDB Length = 450 Score = 30.5 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 20/58 (34%), Gaps = 12/58 (20%) Query: 44 LPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSV 101 LLG+ R+ G TY G+ PV+ + D V + +C Sbjct: 54 WLLLGHETQIRKP------------GDYITTYMGEDPVVVVRQKDASIAVFLNQCRHR 99 >2B8N-A nrPDB Length = 429 Score = 30.5 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 19/72 (26%), Positives = 25/72 (34%), Gaps = 7/72 (9%) Query: 325 PDVQQKLQKEIDAVLPNKAPPTYDAVVQME--YLDMVVNETLRLFPVAIRLERTCKKDVE 382 P+ +KL EI P + LD V+ L V R K E Sbjct: 16 PESLKKLAIEIVKKSIEAVFPDRAVKETLPKLNLDRVI-----LVAVGKAAWRMAKAAYE 70 Query: 383 INGVFIPKGSMV 394 + G I KG +V Sbjct: 71 VLGKKIRKGVVV 82 >3RFT-A nrPDB Length = 267 Score = 29.8 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 10/54 (18%), Positives = 17/54 (31%), Gaps = 10/54 (18%) Query: 396 IPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALM 449 I + +H Y+ + E P+ ++ G C G A M Sbjct: 106 IVFASSNHTIGYYPQTERLGPDVPARPDGL----------YGVSKCFGENLARM 149 >4DJD-D nrPDB Length = 323 Score = 29.8 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 20/36 (55%), Gaps = 1/36 (2%) Query: 309 TTSSVLSFTLY-ELATHPDVQQKLQKEIDAVLPNKA 343 T +++L + L HP+ ++++ ID ++ + A Sbjct: 287 TATALLQAGAHILLMRHPEAVARVKENIDQLMVSNA 322 >3RP9-A nrPDB Length = 458 Score = 28.6 bits (62), Expect = 6.5, Method: Composition-based stats. Identities = 10/57 (17%), Positives = 18/57 (31%), Gaps = 3/57 (5%) Query: 322 ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQME---YLDMVVNETLRLFPVAIRLER 375 HP ++ E++ K ++ + M+ V E R P R Sbjct: 395 LAHPFFKEVRIAEVETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQRYHPEIQLPRR 451 >5Y77-A nrPDB Length = 473 Score = 28.6 bits (62), Expect = 7.2, Method: Composition-based stats. Identities = 21/114 (18%), Positives = 41/114 (35%), Gaps = 1/114 (0%) Query: 266 KHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHP 325 + + D L + + + S K S L + + I A + T + +++ + P Sbjct: 355 QRQPDALAIQAMALENYVEMSSKVASPTYLLERELGQIMAQRQPTRFIPRYSMVTFSRLP 414 Query: 326 DVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKK 379 Q + +I L A + + + LD V +E R P L + Sbjct: 415 YAQAMARGQIQEQLLKFAVANHSDLTSIN-LDAVEHEVTRCLPPLSHLCAAALE 467 >4M60-A nrPDB Length = 418 Score = 28.2 bits (61), Expect = 9.4, Method: Composition-based stats. Identities = 10/52 (19%), Positives = 21/52 (40%) Query: 304 FAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEY 355 A E T+ +L T L P+V ++L++ + +++ E Sbjct: 350 LATEEATADLLRETALALVDDPEVARRLRRIQAEMAQEGGTRRAADLIEAEL 401 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.124 0.325 Lambda K H 0.267 0.0383 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,474,462 Number of Sequences: 36641 Number of extensions: 718163 Number of successful extensions: 3025 Number of sequences better than 10.0: 184 Number of HSP's better than 10.0 without gapping: 312 Number of HSP's successfully gapped in prelim test: 44 Number of HSP's that attempted gapping in prelim test: 1800 Number of HSP's gapped (non-prelim): 430 length of query: 502 length of database: 10,336,785 effective HSP length: 101 effective length of query: 401 effective length of database: 6,636,044 effective search space: 2661053644 effective search space used: 2661053644 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.2 bits)