BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P20813 (491 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3IBD-A nrPDB 951 0.0 4H1N-A nrPDB 749 0.0 5E0E-A nrPDB 729 0.0 5E58-A nrPDB 727 0.0 2PG7-A nrPDB 535 e-152 2NNH-A nrPDB 506 e-143 1N6B-A nrPDB 489 e-139 5W0C-A nrPDB 488 e-138 4GQS-A nrPDB 484 e-137 3E6I-A nrPDB 464 e-131 3TBG-A nrPDB 318 3e-87 3DL9-A nrPDB 279 2e-75 4R20-A nrPDB 241 5e-64 6IQ5-A nrPDB 236 2e-62 6DWN-A nrPDB 232 3e-61 2HI4-A nrPDB 212 3e-55 6B82-A nrPDB 211 5e-55 5UYS-A nrPDB 190 1e-48 4R1Z-A nrPDB 189 2e-48 5VBU-A nrPDB 168 4e-42 3QZ1-A nrPDB 165 4e-41 5YLW-A nrPDB 130 1e-30 5VEU-A nrPDB 126 2e-29 6DA2-A nrPDB 123 2e-28 3K9V-A nrPDB 113 2e-25 3MDV-A nrPDB 90 2e-18 3EL3-A nrPDB 83 3e-16 2VE3-A nrPDB 80 2e-15 6C94-A nrPDB 73 2e-13 3S79-A nrPDB 70 2e-12 6AYB-A nrPDB 68 7e-12 4YZR-A nrPDB 65 7e-11 3JUS-A nrPDB 64 1e-10 5FSA-A nrPDB 63 3e-10 3MZS-A nrPDB 60 1e-09 1Q5D-A nrPDB 58 8e-09 3N9Z-A nrPDB 57 2e-08 4KPA-A nrPDB 56 3e-08 2WX2-A nrPDB 53 3e-07 4OQS-A nrPDB 52 7e-07 2W0A-A nrPDB 52 7e-07 4OQR-A nrPDB 51 1e-06 5JLC-A nrPDB 50 2e-06 3NC3-A nrPDB 50 2e-06 3TYW-A nrPDB 50 2e-06 3MGX-A nrPDB 50 2e-06 3EJB-B nrPDB 50 3e-06 6M7X-A nrPDB 49 3e-06 4UBS-A nrPDB 49 4e-06 6M7L-A nrPDB 49 5e-06 6FYJ-A nrPDB 49 6e-06 4ZGX-A nrPDB 49 7e-06 3P3Z-A nrPDB 48 1e-05 5IT1-A nrPDB 47 1e-05 5LIE-A nrPDB 47 1e-05 2ZBZ-A nrPDB 47 1e-05 4GGV-A nrPDB 47 2e-05 1WIY-A nrPDB 47 2e-05 6B11-A nrPDB 47 2e-05 5HDI-A nrPDB 47 2e-05 5Z9I-A nrPDB 47 3e-05 6GK6-A nrPDB 46 4e-05 3ABB-A nrPDB 46 4e-05 6CR2-A nrPDB 45 7e-05 2Y5N-A nrPDB 45 1e-04 5EX6-C nrPDB 44 2e-04 5FYF-A nrPDB 44 2e-04 5FOI-A nrPDB 44 2e-04 4WPZ-A nrPDB 43 3e-04 4DO1-A nrPDB 43 3e-04 2Z36-A nrPDB 43 3e-04 2VZM-A nrPDB 43 4e-04 6G5O-A nrPDB 43 4e-04 3L4D-A nrPDB 43 4e-04 3ABA-A nrPDB 43 4e-04 6G71-A nrPDB 43 4e-04 2XKR-A nrPDB 42 5e-04 5YHJ-A nrPDB 42 5e-04 3SN5-A nrPDB 42 5e-04 4TRI-A nrPDB 42 5e-04 5CJE-A nrPDB 42 6e-04 2WM5-A nrPDB 42 8e-04 4WMZ-A nrPDB 42 8e-04 1LG9-A nrPDB 41 0.001 5Y1I-A nrPDB 41 0.001 5NWS-A nrPDB 40 0.002 3A1L-A nrPDB 40 0.002 5L94-A nrPDB 40 0.002 2FR7-A nrPDB 40 0.002 6CVC-A nrPDB 40 0.003 3R9C-A nrPDB 40 0.003 4RM4-A nrPDB 39 0.004 5DE9-A nrPDB 39 0.004 3IVY-A nrPDB 39 0.004 1UED-A nrPDB 39 0.005 2RFC-A nrPDB 39 0.005 5OFQ-A nrPDB 39 0.005 1Z8P-A nrPDB 39 0.006 2X2N-A nrPDB 39 0.006 2WIO-A nrPDB 39 0.007 5DQN-A nrPDB 38 0.008 4MM0-A nrPDB 38 0.008 1UE8-A nrPDB 38 0.008 5XJN-A nrPDB 37 0.016 2WIY-A nrPDB 37 0.016 5GWE-A nrPDB 37 0.017 1CPT-A nrPDB 37 0.019 1EHE-A nrPDB 37 0.023 3WVS-A nrPDB 37 0.026 2X9P-A nrPDB 36 0.031 3AWQ-A nrPDB 36 0.046 5YSW-A nrPDB 35 0.080 2IJ7-A nrPDB 35 0.10 6GMF-A nrPDB 34 0.15 4Z5P-A nrPDB 33 0.23 6F0B-A nrPDB 33 0.31 3B98-A nrPDB 33 0.31 4YT3-A nrPDB 33 0.35 3DBM-A nrPDB 33 0.40 2ZQJ-A nrPDB 32 0.60 5XNT-A nrPDB 32 0.75 5M0P-A nrPDB 32 0.80 2IAG-A nrPDB 31 1.2 3TKT-A nrPDB 30 1.7 1Q44-A nrPDB 30 1.7 6DCD-A nrPDB 30 2.1 2NZA-A nrPDB 29 3.9 5HWK-A nrPDB 29 4.0 3TML-A nrPDB 29 4.9 3LXD-A nrPDB 29 5.2 2RCM-A nrPDB 28 6.4 3BUJ-A nrPDB 28 8.1 5JGL-A nrPDB 28 8.5 3MCR-A nrPDB 28 9.7 >3IBD-A nrPDB Length = 476 Score = 951 bits (2459), Expect = 0.0, Method: Compositional matrix adjust. Identities = 460/467 (98%), Positives = 465/467 (99%) Query: 25 NTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAI 84 ++ +LPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAI Sbjct: 6 SSKGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAI 65 Query: 85 REALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEE 144 REALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEE Sbjct: 66 REALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEE 125 Query: 145 RIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQ 204 RIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQ Sbjct: 126 RIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQ 185 Query: 205 TFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDL 264 TFSLISSVFGQLFELFSGFLK+FPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAP+DL Sbjct: 186 TFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDL 245 Query: 265 IDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERV 324 IDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERV Sbjct: 246 IDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERV 305 Query: 325 YREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPK 384 YREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPK Sbjct: 306 YREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPK 365 Query: 385 DTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARA 444 DTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARA Sbjct: 366 DTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARA 425 Query: 445 ELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 ELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR Sbjct: 426 ELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 472 >4H1N-A nrPDB Length = 479 Score = 749 bits (1934), Expect = 0.0, Method: Compositional matrix adjust. Identities = 363/472 (76%), Positives = 412/472 (87%) Query: 20 VQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 79 + + ++ +LPPGP PLP+LGNLLQMDR+GLL+SFLR REKYGDVFTV+LG RPVV+LC Sbjct: 1 MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC 60 Query: 80 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK 139 G +AIREALVD+AEAFSGRGKIA+VDP F+GYGVIFANG RW+ LRRFS+ TMRDFGMGK Sbjct: 61 GTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGMGK 120 Query: 140 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199 RSVEERIQEEA+CL+EELRKSKGAL+D T LF SIT+NIICSIVFGKRF Y+D FL++L Sbjct: 121 RSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLL 180 Query: 200 NLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 259 +LF+Q+FSLISS Q+FELFSGFLKYFPG HRQ+Y+NLQEIN +IG SVEKHR TLDPS Sbjct: 181 DLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPS 240 Query: 260 APKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 319 P+D ID YLL MEK+KS+ SEF HQNL L LSLF AGTETTSTTLRYGFLLMLKYPH Sbjct: 241 NPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPH 300 Query: 320 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 379 V ERV +EIEQVIG HRPP L DRAKMPYT+AVI+EIQR DL+P GVPH VT+ T FRG Sbjct: 301 VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRG 360 Query: 380 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 439 Y+IPK+TEVF +LS+ALHDP YFE P+ FNP HFLDANGALK+ E F+PFSLGKRICLGE Sbjct: 361 YVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGE 420 Query: 440 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 GIAR ELFLFFTTILQNFS+ASPV PEDIDLTP+E GVG +PP+YQIRFL R Sbjct: 421 GIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFLAR 472 >5E0E-A nrPDB Length = 463 Score = 729 bits (1883), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/450 (78%), Positives = 398/450 (88%) Query: 42 NLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKI 101 NLLQMDR G L SF R REKYGDVFTVHLGPRPVVML G EAIREALVD+AEAFSGRG I Sbjct: 14 NLLQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 73 Query: 102 AMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSK 161 A+V+P FRGYGV+FANG RWK LRRFS+ TMRDFGMGKRSVEERIQEEA+CL+EE RKS+ Sbjct: 74 AVVEPIFRGYGVVFANGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQ 133 Query: 162 GALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFS 221 GA +DPTFLFQ ITANIICSIVFG+RF Y+D +FL++L LFYQ+FSLISS Q+FELFS Sbjct: 134 GAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFS 193 Query: 222 GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHS 281 GFLKYFPG HRQ+ +NLQEI YIG SVEKHR TLDPS P+D IDTYLL MEKEKSN H+ Sbjct: 194 GFLKYFPGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHT 253 Query: 282 EFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELH 341 EF HQNL ++ LSLFFAGTET+STTLRYGFLLMLKYPHVAE+V +EI+QVIG HR P L Sbjct: 254 EFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 313 Query: 342 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 401 DR KMPYTEAVIYEIQRFSDL+P+GVPH VT+ T FRGY++PK+TEV+ ILS+ALHDP Y Sbjct: 314 DRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 373 Query: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 461 FE+PD FNPDHFLDANGALKK+EAF+PFS+GKRICLGEGIAR ELFLFFTTILQNFS++S Sbjct: 374 FEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLSS 433 Query: 462 PVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 PVAP+DIDL+P+E G GK+P TYQI FL R Sbjct: 434 PVAPKDIDLSPKESGFGKVPQTYQICFLAR 463 >5E58-A nrPDB Length = 493 Score = 727 bits (1877), Expect = 0.0, Method: Compositional matrix adjust. Identities = 343/450 (76%), Positives = 397/450 (88%) Query: 42 NLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKI 101 NLLQMDR G L SF+R REKYGDVFTVHLGPRPVVML G EAIREALVD+AEAFSGRG I Sbjct: 42 NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 101 Query: 102 AMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSK 161 A++ P YG+IF+NG RWKVLRRFS+ TMRDFGMGKRSVE+RIQEEAQCL+EEL+KS+ Sbjct: 102 AVIKPVIGDYGMIFSNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQ 161 Query: 162 GALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFS 221 GA +DPTFLFQ ITANIICSIVFG+R+ Y+D++FL++L+LFY+TFSL+SS Q+FELFS Sbjct: 162 GAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFS 221 Query: 222 GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHS 281 GF+KYFPGAHRQ+ +NLQEI Y+G SVEKHR TLDPS P+D IDTYLL MEKEKSN H+ Sbjct: 222 GFMKYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHT 281 Query: 282 EFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELH 341 EF HQNL ++ LSLFFAGTETTSTTLRYGFLLMLKYPHVAE+V +EI+QVIG HR P L Sbjct: 282 EFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 341 Query: 342 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 401 DR KMPYT+AVI+EIQRFSDL P+G PH VT+ T FRGY++PK+TEV+ ILS+ALHDP Y Sbjct: 342 DRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 401 Query: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 461 FE+P FNPDHFLDANGALKK+EAF+PFS+GKRICLGEGIAR ELFLFFTTILQNFS++S Sbjct: 402 FEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSS 461 Query: 462 PVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 VAP+DIDL+P+E G+GK+P TYQI FL R Sbjct: 462 SVAPKDIDLSPKESGIGKVPQTYQISFLAR 491 >2PG7-A nrPDB Length = 476 Score = 535 bits (1377), Expect = e-152, Method: Compositional matrix adjust. Identities = 245/470 (52%), Positives = 338/470 (71%) Query: 22 RHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGV 81 + ++ +LPPGP PLP +GN LQ++ + S ++ E+YG VFT+HLGPR VV+LCG Sbjct: 3 KKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGH 62 Query: 82 EAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRS 141 +A+REALVD+AE FSGRG+ A D F+GYGV+F+NG R K LRRFS+ T+RDFG+GKR Sbjct: 63 DAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRG 122 Query: 142 VEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNL 201 +EERIQEEA LI+ LR + GA +DPTF +N+I SIVFG RF Y+D+EFL +L + Sbjct: 123 IEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRM 182 Query: 202 FYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAP 261 F S+ GQL+E+FS +K+ PG +Q ++ LQ + +I VE ++ TLDP++P Sbjct: 183 MLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSP 242 Query: 262 KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVA 321 +D ID++L+ M++E+ N ++EF +NL + TL LF GTET STTLRYGFLL++K+P V Sbjct: 243 RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPEVE 302 Query: 322 ERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYI 381 +V+ EI++VIG +R P+ DRAKMPY EAVI+EIQRF D++PM + V + T FR + Sbjct: 303 AKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFF 362 Query: 382 IPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGI 441 +PK TEV+ +L + L DP +F P FNP HFL+ G KK++AF+PFS+GKR C GEG+ Sbjct: 363 LPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGL 422 Query: 442 ARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 AR ELFLFFTT++QNF + S +P+DID++P+ G IP Y + FLPR Sbjct: 423 ARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 472 >2NNH-A nrPDB Length = 476 Score = 506 bits (1303), Expect = e-143, Method: Compositional matrix adjust. Identities = 238/462 (51%), Positives = 325/462 (70%) Query: 29 RLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREAL 88 +LPPGP PLP++GN+LQ+D + + KSF F + YG VFTV+ G P+V+ G EA++EAL Sbjct: 10 KLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEAL 69 Query: 89 VDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQE 148 +D E FSGRG + +G G+I +NG RWK +RRFS+TT+R+FGMGKRS+E+R+QE Sbjct: 70 IDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQE 129 Query: 149 EAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSL 208 EA CL+EELRK+K + DPTF+ N+ICS+VF KRF Y+DQ FL ++ F + F + Sbjct: 130 EAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRI 189 Query: 209 ISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTY 268 ++S + Q+ F + FPG H +V KN+ +YI V++H+ +LD + P+D ID + Sbjct: 190 LNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCF 249 Query: 269 LLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREI 328 L+ ME+EK N SEF+ +NL LF AGTETTSTTLRYG LL+LK+P V +V EI Sbjct: 250 LIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEI 309 Query: 329 EQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEV 388 + VIG HR P + DR+ MPYT+AV++EIQR+SDL+P GVPH VT T FR Y+IPK T + Sbjct: 310 DHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTI 369 Query: 389 FLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFL 448 +L++ LHD F P+ F+P HFLD NG KK++ F+PFS GKRIC GEG+AR ELFL Sbjct: 370 MALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFL 429 Query: 449 FFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLP 490 F TTILQNF++ S ++++ T G+ +PP+YQI F+P Sbjct: 430 FLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIP 471 >1N6B-A nrPDB Length = 473 Score = 489 bits (1260), Expect = e-139, Method: Compositional matrix adjust. Identities = 231/471 (49%), Positives = 329/471 (69%), Gaps = 3/471 (0%) Query: 20 VQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 79 + + ++ +LPPGP P P++GN+LQ+D + + KS +F E YG VFTV+LG +P V+L Sbjct: 1 MAKKTSSKGKLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLH 60 Query: 80 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK 139 G EA++EALVD E F+GRG + +++ +G G+ F+N WK +RRFS+ T+R+FGMGK Sbjct: 61 GYEAVKEALVDLGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGK 120 Query: 140 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199 RS+E+RIQEEA+CL+EELRK+ + DPTF+ N+ICS++F RF Y+D+EFLK++ Sbjct: 121 RSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLM 180 Query: 200 NLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 259 ++ L+ + + Q++ F L YFPG H+ + KN I +I V++H++ LD + Sbjct: 181 ESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVN 240 Query: 260 APKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 319 P+D ID +L+ ME+E + EF+ ++L + LF AGTETTSTTLRY LL+LK+P Sbjct: 241 NPRDFIDCFLIKMEQEN---NLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPE 297 Query: 320 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 379 VA RV EIE+VIG HR P + DR++MPYT+AVI+EIQRF DLLP +PH VT+ FR Sbjct: 298 VAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRN 357 Query: 380 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 439 Y IPK T++ L++ LHD F P F+P HFLD +G KK++ F+PFS GKR+C+GE Sbjct: 358 YFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGE 417 Query: 440 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLP 490 G+AR ELFLF T+ILQNF + S V P+D+D+T G +PP+YQ+ F+P Sbjct: 418 GLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFIP 468 >5W0C-A nrPDB Length = 477 Score = 488 bits (1257), Expect = e-138, Method: Compositional matrix adjust. Identities = 228/472 (48%), Positives = 331/472 (70%) Query: 19 LVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVML 78 + ++ + +LPPGP PLP++GN+LQ+ + + KS + YG VFT++ G +P+V+L Sbjct: 1 MAKKTSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL 60 Query: 79 CGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMG 138 G EA++EAL+D E FSGRG + + RG+G++F+NG +WK +RRFS+ T+R+FGMG Sbjct: 61 HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 120 Query: 139 KRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKM 198 KRS+E+R+QEEA+CL+EELRK+K + DPTF+ N+ICSI+F KRF Y+DQ+FL + Sbjct: 121 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNL 180 Query: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDP 258 + + ++SS + Q+ FS + YFPG H ++ KN+ + +YI V++H+E++D Sbjct: 181 MEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDM 240 Query: 259 SAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP 318 + P+D ID +L+ MEKEK N SEF+ ++L + LF AGTETTSTTLRY LL+LK+P Sbjct: 241 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 300 Query: 319 HVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378 V +V EIE+VIG +R P + DR+ MPYT+AV++E+QR+ DLLP +PH VT FR Sbjct: 301 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 360 Query: 379 GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLG 438 Y+IPK T + + L++ LHD F P+ F+P HFLD G KK++ F+PFS GKRIC+G Sbjct: 361 NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVG 420 Query: 439 EGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLP 490 E +A ELFLF T+ILQNF++ S V P+++D TP G +PP YQ+ F+P Sbjct: 421 EALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP 472 >4GQS-A nrPDB Length = 477 Score = 484 bits (1247), Expect = e-137, Method: Compositional matrix adjust. Identities = 226/472 (47%), Positives = 324/472 (68%) Query: 19 LVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVML 78 + ++ + +LPPGP PLP++GN+LQ+D + + KS + YG VFT++ G +V+L Sbjct: 1 MAKKTSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL 60 Query: 79 CGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMG 138 G E ++EAL+D E FSGRG + + RG+G++F+NG RWK +RRFS+ T+R+FGMG Sbjct: 61 HGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMG 120 Query: 139 KRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKM 198 KRS+E+R+QEEA+CL+EELRK+K + DPTF+ N+ICSI+F KRF Y+DQ+FL + Sbjct: 121 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNL 180 Query: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDP 258 + + ++S+ + Q+ F + YFPG H ++ KNL + + I V++H+E++D Sbjct: 181 MEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDI 240 Query: 259 SAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP 318 + P+D ID +L+ MEKEK N SEF+ +NL + L AGTETTSTTLRY LL+LK+P Sbjct: 241 NNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP 300 Query: 319 HVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378 V +V EIE+V+G +R P + DR MPYT+AV++E+QR+ DL+P +PH VT FR Sbjct: 301 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFR 360 Query: 379 GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLG 438 Y+IPK T + L++ LHD F P+ F+P HFLD G KK+ F+PFS GKRIC+G Sbjct: 361 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 420 Query: 439 EGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLP 490 EG+AR ELFLF T ILQNF++ S + P+D+D TP G +PP YQ+ F+P Sbjct: 421 EGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 472 >3E6I-A nrPDB Length = 476 Score = 464 bits (1195), Expect = e-131, Method: Compositional matrix adjust. Identities = 220/467 (47%), Positives = 319/467 (68%), Gaps = 1/467 (0%) Query: 25 NTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAI 84 ++ +LPPGP PLP++GNL Q++ + + KSF R +++G VFT+++G + +V++ G +A+ Sbjct: 6 SSKGKLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAV 65 Query: 85 REALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEE 144 +EAL+D + FSGRG + R G+IF NG WK +RRFS+TT+R++GMGK+ E Sbjct: 66 KEALLDYKDEFSGRGDLPAFHAH-RDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNES 124 Query: 145 RIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQ 204 RIQ EA L+E LRK++G DPTFL N+I I+F K F Y D++FL+++ LF + Sbjct: 125 RIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNE 184 Query: 205 TFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDL 264 F L+S+ + QL+ F FL Y PG+HR+V KN+ E+ Y+ V++H ++LDP+ P+DL Sbjct: 185 NFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDL 244 Query: 265 IDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERV 324 D L+ MEKEK +A ++ + + LFFAGTETTSTTLRYG L+++KYP + E++ Sbjct: 245 TDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKL 304 Query: 325 YREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPK 384 + EI++VIGP R P + DR +MPY +AV++EIQRF L+P +PH T+ T FRGY+IPK Sbjct: 305 HEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPK 364 Query: 385 DTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARA 444 T V L + L+D F P+ F P+HFL+ NG K ++ F PFS GKR+C GEG+AR Sbjct: 365 GTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARM 424 Query: 445 ELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 ELFL ILQ+F++ V P+DIDL+P G G IPP Y++ +PR Sbjct: 425 ELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 471 >3TBG-A nrPDB Length = 479 Score = 318 bits (815), Expect = 3e-87, Method: Compositional matrix adjust. Identities = 171/415 (41%), Positives = 244/415 (58%), Gaps = 6/415 (1%) Query: 55 FLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFF---RGY 111 F + R ++GDVF++ L PVV+L G+ A+REALV E + R + + R Sbjct: 36 FDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQ 95 Query: 112 GVIFAN-GNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFL 170 GV A G W+ RRFSV+T+R+ G+GK+S+E+ + EEA CL G P L Sbjct: 96 GVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGL 155 Query: 171 FQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGA 230 +N+I S+ G+RF Y D FL++L+L + S ++ L + P Sbjct: 156 LDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPAL 214 Query: 231 HRQVYKNLQEINAYIGHSVEKHRETLDPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLN 289 +V + + + + +HR T DP+ P +DL + +L MEK K N S F+ +NL Sbjct: 215 AGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLR 274 Query: 290 LNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYT 349 + LF AG TTSTTL +G LLM+ +P V RV +EI+ VIG R PE+ D+A MPYT Sbjct: 275 IVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYT 334 Query: 350 EAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFN 409 AVI+E+QRF D++P+GV H+ ++ +G+ IPK T + LS+ L D +EKP F+ Sbjct: 335 TAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFH 394 Query: 410 PDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVA 464 P+HFLDA G K EAF+PFS G+R CLGE +AR ELFLFFT++LQ+FS + P Sbjct: 395 PEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 449 >3DL9-A nrPDB Length = 479 Score = 279 bits (714), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 147/404 (36%), Positives = 233/404 (57%), Gaps = 5/404 (1%) Query: 62 YGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFAN-GNR 120 YG++F++ LG V+L G + ++E LV ++E F+ R + + + G++ + G Sbjct: 47 YGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRG 106 Query: 121 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC 180 W RR +V + R FG G++S E +I EE + + + KG D L + +NI Sbjct: 107 WVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITN 166 Query: 181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFS--GFLKYFPGAHRQVYKNL 238 I+FG+RF Y+D +F M+ LF + L +S L+ F G L + G H+Q+++N Sbjct: 167 LIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF--GKHQQLFRNA 224 Query: 239 QEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFA 298 + ++ +EK P P+ +D YL M++ K++ S FS +NL + L A Sbjct: 225 AVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIA 284 Query: 299 GTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQR 358 GTETT+ LR+ L M YP++ +V +EI+ ++GP+ P D+ KMPYTEAV++E+ R Sbjct: 285 GTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLR 344 Query: 359 FSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANG 418 F +++P+G+ H ++ RGY IPK T V L + D Y+ P+ F+P+ FLD++G Sbjct: 345 FCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSG 404 Query: 419 ALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462 K EA +PFSLG+R CLGE +AR E+FLFFT +LQ F + P Sbjct: 405 YFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP 448 >4R20-A nrPDB Length = 486 Score = 241 bits (615), Expect = 5e-64, Method: Compositional matrix adjust. Identities = 136/440 (30%), Positives = 228/440 (51%), Gaps = 8/440 (1%) Query: 55 FLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRG-YGV 113 F + +YG +F ++ GP +++ + +RE L+ + F+GR K+ D +G + Sbjct: 45 FTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQGGKDI 104 Query: 114 IFAN-GNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQ 172 FA+ WK RR ++ FG G ++ +QE A L EEL+ +G D + + Sbjct: 105 AFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSVVLM 164 Query: 173 SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHR 232 N+IC +VF + D E ++ Y + + G L ++F +L+ FP Sbjct: 165 RAVTNVICRLVFSSSYQPSDPELQTVIQ--YNDGIVQTIARGGLVDIFP-WLRIFPNKDL 221 Query: 233 QVYKNLQEI-NAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLN 291 + K I + + + +H+++L P P+DL+D L+ ++ A + + ++ + Sbjct: 222 KRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGGA-DDITEDHVLMT 280 Query: 292 TLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEA 351 F AG ETTSTTL + +L +P + ERV E+++ +G RPP L DR +P +A Sbjct: 281 AAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDA 340 Query: 352 VIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPD 411 V+ E+ R + P+ +PH+ Q TS G+ +PK T V + + HDP ++++P+ FNP+ Sbjct: 341 VLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPE 400 Query: 412 HFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLT 471 FL+ +G K +F+PF G R+C+GE +AR ELFLF + LQ FS + P DL Sbjct: 401 RFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPSEASLPDLQ 460 Query: 472 PQECGVGKIPPTYQIRFLPR 491 + GV P Y + PR Sbjct: 461 GR-FGVVLQPERYTVTVTPR 479 >6IQ5-A nrPDB Length = 463 Score = 236 bits (602), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 145/437 (33%), Positives = 239/437 (54%), Gaps = 22/437 (5%) Query: 54 SFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGV 113 SF R +YGDVF + LG P+V+L G AI +ALV + AF+ R A G + Sbjct: 6 SFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGRSM 65 Query: 114 IFAN-GNRWKVLRRFSVTTMRDF----GMGKRSVEERIQEEAQCLIEELRK--SKGALMD 166 F + WKV RR + + MR+F ++ +E + EA+ L+ L + + GA +D Sbjct: 66 AFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLD 125 Query: 167 PTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKY 226 P L AN++ ++ FG R+ + D EF ++L+ + + + G L ++ +L+Y Sbjct: 126 PRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGA--GSLVDVMP-WLQY 182 Query: 227 FPGAHRQVYKNLQEIN----AYIGHSVEKHRETLDP-SAPKDLIDTYLLHMEKEKS-NAH 280 FP R V++ +++N +I +H E+L P +AP+D++D ++L EK+ + ++H Sbjct: 183 FPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSH 242 Query: 281 ---SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRP 337 + +N+ +F A +T ST L++ LL +YP V RV E++QV+G R Sbjct: 243 GGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRL 302 Query: 338 PELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALH 397 P + D+ +PY A +YE RFS +P+ +PH T +TS GY IPKDT VF+ + H Sbjct: 303 PCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNH 362 Query: 398 DPHYFEKPDAFNPDHFLDANGALKK--TEAFIPFSLGKRICLGEGIARAELFLFFTTILQ 455 DP + P+ F+P FLD +G + K T + FS+GKR C+GE +++ +LFLF + + Sbjct: 363 DPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAH 422 Query: 456 NFSM-ASPVAPEDIDLT 471 A+P P ++ + Sbjct: 423 QCDFRANPNEPAKMNFS 439 >6DWN-A nrPDB Length = 491 Score = 232 bits (592), Expect = 3e-61, Method: Compositional matrix adjust. Identities = 146/459 (31%), Positives = 243/459 (52%), Gaps = 23/459 (5%) Query: 31 PPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVD 90 PPGP PL+G++L + + L + R ++YGDV + +G PVV+L G++ IR+ALV Sbjct: 13 PPGPWGWPLIGHMLTLGKNPHL-ALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR 71 Query: 91 KAEAFSGRGKIAMVDPFFRGYGVIFA--NGNRWKVLRRFSVTTMRDFGMGKRS------- 141 + + F GR + G + F+ +G W RR + ++ F + Sbjct: 72 QGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCY 131 Query: 142 VEERIQEEAQCLI---EELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKM 198 +EE + +EA+ LI +EL G ++ S+T N+IC+I FG+R+ + QE L + Sbjct: 132 LEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVT-NVICAICFGRRYDHNHQELLSL 190 Query: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE-INAYIGHSVEKHRETLD 257 +NL ++ S G + F L+Y P +K+L E +++ V++H +T + Sbjct: 191 VNLNNNFGEVVGS--GNPAD-FIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFE 247 Query: 258 PSAPKDLIDTYLLHMEKEK--SNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315 +D+ D+ + H ++++ NA+ + S + + L LF AG +T +T + + + ++ Sbjct: 248 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 307 Query: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375 P V ++ E++ VIG R P L DR+ +PY EA I E R S +P +PH T+ T Sbjct: 308 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT 367 Query: 376 SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK--TEAFIPFSLGK 433 S +G+ IPK VF+ HD + P F P+ FL +GA+ K +E I F +GK Sbjct: 368 SLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGK 427 Query: 434 RICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTP 472 R C+GE IAR E+FLF +LQ + P+ + +D+TP Sbjct: 428 RKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTP 465 >2HI4-A nrPDB Length = 495 Score = 212 bits (540), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 134/457 (29%), Positives = 226/457 (49%), Gaps = 20/457 (4%) Query: 31 PPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVD 90 PP P PLLG++L + + L + R ++YGDV + +G PV++L ++ IR+ALV Sbjct: 18 PPEPWGWPLLGHVLTLGKNPHL-ALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVR 76 Query: 91 KAEAFSGRGKIAMVDPFFRGYGVIFA--NGNRWKVLRRFSVTTMRDFGMGKRS------- 141 + + F GR + G + F+ +G W RR + + F + Sbjct: 77 QGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCY 136 Query: 142 VEERIQEEAQCLIEELRK--SKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199 +EE + +EA+ LI L++ + DP AN+I ++ FG+ F E L ++ Sbjct: 137 LEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLV 196 Query: 200 NLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL-QEINAYIGHSVEKHRETLDP 258 ++ SS G + F L+Y P Q +K Q ++ +V++H + D Sbjct: 197 KNTHEFVETASS--GNPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDK 253 Query: 259 SAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP 318 ++ +D+ H +K + + + + +F AG +T +T + + + ++ P Sbjct: 254 NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKP 313 Query: 319 HVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378 + ++ +E++ VIG R P L DR ++PY EA I E R S LP +PH T+ T+ Sbjct: 314 EIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLN 373 Query: 379 GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANG-ALKK--TEAFIPFSLGKRI 435 G+ IPK VF+ HDP +E P F P+ FL A+G A+ K +E + F +GKR Sbjct: 374 GFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRR 433 Query: 436 CLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTP 472 C+GE +A+ E+FLF +LQ + P + +DLTP Sbjct: 434 CIGEVLAKWEIFLFLAILLQQLEFSVPPGVK-VDLTP 469 >6B82-A nrPDB Length = 509 Score = 211 bits (537), Expect = 5e-55, Method: Compositional matrix adjust. Identities = 125/447 (27%), Positives = 224/447 (50%), Gaps = 13/447 (2%) Query: 28 DRLPPGPRPLPLLGNLLQMDRRGLLKSFLR-FREKYGDVFTVHLGPRPVVMLCGVEAIRE 86 +R PP LP++G+L+ + F + ++KYGD++++ +G ++++ +E Sbjct: 22 NRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHHHAKE 81 Query: 87 ALVDKAEAFSGRGKIAMVDPFFR-GYGVIFAN-GNRWKVLRRFSVTTMRDFGMGKRSVEE 144 L+ K + F+GR + D R G + FA+ + WK R+ + FG G S+E+ Sbjct: 82 ILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSVSIEK 141 Query: 145 RIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQ 204 I EA + E L +S+ + +D N++C++ F + D EF ML Y Sbjct: 142 IICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKRGDAEFESMLQ--YS 199 Query: 205 TFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEI-NAYIGHSVEKHRETLDPSAPKD 263 + + L ++F +L+ FP ++ + I + + E+H+ T + +D Sbjct: 200 QGIVDTVAKDSLVDIFP-WLQIFPNKDLRILRQCISIRDKLLQKKYEEHKVTYSDNVQRD 258 Query: 264 LIDTYLLHMEKEKSNAHSE----FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 319 L+D L ++N S + ++ + +F AG ETT+TTL++ ++ P Sbjct: 259 LLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQ 318 Query: 320 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 379 V ++ E++ IG R P+L DR +PY EA I E+ R + P+ +PH+ Q +S Sbjct: 319 VQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVALQDSSVGE 378 Query: 380 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLD--ANGALKKTEAFIPFSLGKRICL 437 Y + K T V + + + HD ++ P+ F+P FL+ +G + +++PF G R+CL Sbjct: 379 YTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCL 438 Query: 438 GEGIARAELFLFFTTILQNFSMASPVA 464 GE +A+ ELFLF ILQ F++ P Sbjct: 439 GEALAKMELFLFLAWILQRFTLEMPTG 465 >5UYS-A nrPDB Length = 494 Score = 190 bits (483), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 132/450 (29%), Positives = 227/450 (50%), Gaps = 17/450 (3%) Query: 26 THDRLPPGPRPLPLLGNLLQMDRRGLL-KSFLRFREKYGDVFTVHLGPRPVVMLCGVEAI 84 T + P LPL+G+L + R G + +F + ++KYG +++V +G + V++ + Sbjct: 5 TGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLA 64 Query: 85 REALVDKAEAFSGRGKIAMVDPFFRG-YGVIFAN-GNRWKVLRRFSVTTMRDFGMGKRSV 142 +E L+ K + FSGR ++A +D G+ FA+ G W++ RR ++ T F G + + Sbjct: 65 KEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKL 124 Query: 143 EERIQEEAQCLIEELRKSKGALMDPTF-LFQSITANIICSIVFGKRFHYQDQEFLKMLNL 201 E+ I +E L + L G +D +F +F ++T N+I I F + D E + N Sbjct: 125 EKIICQEISTLCDMLATHNGQSIDISFPVFVAVT-NVISLICFNTSYKNGDPELNVIQNY 183 Query: 202 FYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEI-NAYIGHSVEKHRETLDPSA 260 +S L +L +LK FP + K+ +I N + +E ++E + Sbjct: 184 NEGIIDNLSK--DSLVDLVP-WLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDS 240 Query: 261 PKDLIDTYL-LHMEKEKSNA----HSEFSHQNLNLNTL-SLFFAGTETTSTTLRYGFLLM 314 +++DT + M + NA SE N L T+ +F AG ETT++ +++ + Sbjct: 241 ITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFL 300 Query: 315 LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH 374 L P V +++Y EI+Q +G R P + DR ++ EA I E+ R + PM +PH Sbjct: 301 LHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVD 360 Query: 375 TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGA--LKKTEAFIPFSLG 432 +S + + K TEV + L H+ + +PD F P+ FL+ G + + +++PF G Sbjct: 361 SSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAG 420 Query: 433 KRICLGEGIARAELFLFFTTILQNFSMASP 462 R C+GE +AR ELFL +LQ F + P Sbjct: 421 PRSCIGEILARQELFLIMAWLLQRFDLEVP 450 >4R1Z-A nrPDB Length = 439 Score = 189 bits (481), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 112/389 (28%), Positives = 191/389 (49%), Gaps = 12/389 (3%) Query: 85 REALVDKAEAFSGRGKIAMVDPFFR-GYGVIFAN-GNRWKVLRRFSVTTMRDFGMGKRSV 142 +E L+ K + F+GR + D R G + FA+ + WK R+ + FG G S+ Sbjct: 16 KEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSVSI 75 Query: 143 EERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLF 202 E+ I EA + E L +S+ + +D N++C++ F + D EF ML Sbjct: 76 EKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKRGDAEFESMLQ-- 133 Query: 203 YQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEI-NAYIGHSVEKHRETLDPSAP 261 Y + + L ++F +L+ FP + + I + + E+H+ T + Sbjct: 134 YSQGIVDTVAKDSLVDIFP-WLQIFPNKDLTILRQCISIRDKLLQKKYEEHKVTYSDNVQ 192 Query: 262 KDLIDTYLLHMEKEKSNAHSE----FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKY 317 +DL+D L ++N S + ++ + +F AG ETT+T L++ ++ Sbjct: 193 RDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHN 252 Query: 318 PHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF 377 P V ++ E++ IG R P+L DR +PY EA I E+ R + P+ +PH+ Q +S Sbjct: 253 PQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPVSPLLIPHVALQDSSV 312 Query: 378 RGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLD--ANGALKKTEAFIPFSLGKRI 435 Y + K T V + L + HD ++ P+ F+P FL+ +G + +++PF G R+ Sbjct: 313 GEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRV 372 Query: 436 CLGEGIARAELFLFFTTILQNFSMASPVA 464 CLGE +A+ ELFLF ILQ F++ P Sbjct: 373 CLGEALAKMELFLFLAWILQRFTLEMPTG 401 >5VBU-A nrPDB Length = 476 Score = 168 bits (426), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 128/467 (27%), Positives = 227/467 (48%), Gaps = 27/467 (5%) Query: 38 PLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSG 97 PL L + + L L +K+G ++ +HLG + VV+L I EA+V K F+G Sbjct: 13 PLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAG 72 Query: 98 RGKIAMVDPFFRGYGVIFANGNR--WKVLRRFSVTTMRDFGMGKR-SVEERIQEEAQCLI 154 R + R Y + WK ++ + + + +G R S+E +++ Q Sbjct: 73 RPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFC 129 Query: 155 EELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQD--QEFLKMLNLFYQTFSLISSV 212 E +R G + F +T +IIC + FG + + + K + +T+S S Sbjct: 130 ERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSI- 188 Query: 213 FGQLFELFSGFLKYFPG-AHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLH 271 Q+ ++ FL++FP R++ + +++ + + + +H+E+L +D++D Y+L Sbjct: 189 --QIVDVIP-FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMD-YMLQ 244 Query: 272 MEKEKS--NAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIE 329 + S + ++++ + L GTETT+ TL + + +L +P + +R+ E++ Sbjct: 245 GVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELD 304 Query: 330 QVIGP----HRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKD 385 +GP R P DRA++P A I E+ R ++P+ +PH T+ +S GY IP+ Sbjct: 305 HELGPGASSSRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEG 363 Query: 386 TEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAE 445 T + L A D +E+P F PD FL+ K + F G R+CLGE +AR E Sbjct: 364 TVIIPNLQGAHLDETVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLE 419 Query: 446 LFLFFTTILQNFS-MASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 LF+ T +LQ F+ + S A + P + K+ P +Q+R PR Sbjct: 420 LFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQP-FQVRLQPR 465 >3QZ1-A nrPDB Length = 496 Score = 165 bits (418), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 124/470 (26%), Positives = 221/470 (47%), Gaps = 34/470 (7%) Query: 38 PLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSG 97 PL+ L + + L L +K G V+ + LG + VV+L I EA++ K F+G Sbjct: 32 PLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAG 91 Query: 98 RGKIA--------MVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRS-VEERIQE 148 R +I D Y ++ WK ++ + + + +G RS +E + + Sbjct: 92 RPQIPSYKLVSQRCQDISLGDYSLL------WKAHKKLTRSALL---LGTRSSMEPWVDQ 142 Query: 149 EAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSL 208 Q E +R GA + F +T +IIC + FG + F + +T+ Sbjct: 143 LTQEFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLMKTWDH 202 Query: 209 ISSVFGQLFELFSGFLKYFPG-AHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDT 267 S Q+ ++ FL++FP ++ + ++ + + + +H+E++ +D+ D Sbjct: 203 WSI---QILDMVP-FLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDY 258 Query: 268 YLLHMEKEK-SNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYR 326 L + +++ + +++++ + LF GTETT++TL + +L +P + R+ Sbjct: 259 MLQGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQE 318 Query: 327 EIEQVIGPHRPPE---LHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIP 383 E+++ +GP DRA++P A I E+ R ++P+ +PH T+ +S GY IP Sbjct: 319 ELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIP 378 Query: 384 KDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIAR 443 + V L A D +E+P F PD FL+ + + F G R+CLGE +AR Sbjct: 379 EGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGA----NPSALAFGCGARVCLGESLAR 434 Query: 444 AELFLFFTTILQNFSMASPVAPEDIDLTPQE-CGVG-KIPPTYQIRFLPR 491 ELF+ +LQ F++ P L P CGV K+ P +Q+R PR Sbjct: 435 LELFVVLARLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQP-FQVRLQPR 483 >5YLW-A nrPDB Length = 495 Score = 130 bits (327), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 120/481 (24%), Positives = 213/481 (44%), Gaps = 53/481 (11%) Query: 3 LSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKY 62 L+ L F+A L +R+ LPPGP P P++GN+LQ+ + F + ++Y Sbjct: 7 LAALFFIAATITFLSFRRRRN------LPPGPFPYPIVGNMLQLGANPH-QVFAKLSKRY 59 Query: 63 GDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMV-----DPFFRGYGVIFAN 117 G + ++HLG V++ E +E L + FSGR V D G+ + Sbjct: 60 GPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFLPV--- 116 Query: 118 GNRWKVLRRFSVTTMRDFGMGKRSVEERI---QEEAQCLIEELRK--SKGALMDPTFLFQ 172 + W+ +R+ M +S+E +++ Q L++ ++K G +D Sbjct: 117 ASEWRDMRKICKEQM----FSNQSMEASQGLRRQKLQQLLDHVQKCSDSGRAVDIREAAF 172 Query: 173 SITANIICSIVFGKRFHYQDQEFLKMLNL-FYQTFSLISSVFGQLFELFSGFLKYFP--- 228 T N++ + +F Q EF + F + ++++ G F YFP Sbjct: 173 ITTLNLMSATLFSS----QATEFDSKATMEFKEIIEGVATIVG-----VPNFADYFPILR 223 Query: 229 -----GAHRQVY----KNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYL-LHMEKEKSN 278 G R+ K L +I Y+ +E R +P+APK D +L + ++ ++N Sbjct: 224 PFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRA--NPNAPKK--DDFLEIVVDIIQAN 279 Query: 279 AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP 338 +H +L L LF G++T +T++ + ++ P R+ E++ V G + Sbjct: 280 EFKLKTHHFTHL-MLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIV 338 Query: 339 ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHD 398 + K+PY +AVI E+ R P+ +P GY+IPK T++ + D Sbjct: 339 DESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRD 398 Query: 399 PHYFEKPDAFNPDHFLDANGALKKTE-AFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 P + P+ F+P+ FLD K + +PF G+R+C G +A L + T++ NF Sbjct: 399 PSIWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNF 458 Query: 458 S 458 Sbjct: 459 D 459 >5VEU-A nrPDB Length = 480 Score = 126 bits (316), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 113/439 (25%), Positives = 189/439 (43%), Gaps = 26/439 (5%) Query: 32 PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDK 91 PGP PLPLLGN+L R+GL K +KYG ++ + G PV+ + + IR LV + Sbjct: 18 PGPTPLPLLGNVLSY-RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 76 Query: 92 A-EAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEE 149 F+ R + V F + A WK +R T F GK + + I + Sbjct: 77 CYSVFTNRRSLGPVG--FMKSAISLAEDEEWKRIRSLLSPT---FTSGKLKEMFPIIAQY 131 Query: 150 AQCLIEELRKS--KGALMDPTFLFQSITANIICSIVFG---KRFHYQDQEFLKMLNLFYQ 204 L+ LR+ KG + +F + + ++I FG + F++ F + Sbjct: 132 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 191 Query: 205 TFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDL 264 F + +F + LF F + ++ IN ++ SV + +++ K Sbjct: 192 -FGFLDPLFLSII-LFPFLTPVFEALNVSLFPK-DTIN-FLSKSVNRMKKSRLNDKQKHR 247 Query: 265 IDTYLLHMEKEKSN---AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVA 321 +D L ++ + S +H S L ++ FAG ETTS+ L + + +P V Sbjct: 248 LDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQ 307 Query: 322 ERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGV--PHIVTQHTSFRG 379 +++ +EI+ V+ PP +M Y + V+ E R L P+ + + G Sbjct: 308 QKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR---LFPVAIRLERTCKKDVEING 364 Query: 380 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 439 IPK + V + HDP Y+ +P+ F P+ F ++ + PF G R C+G Sbjct: 365 VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY-IYTPFGTGPRNCIGM 423 Query: 440 GIARAELFLFFTTILQNFS 458 A + L +LQNFS Sbjct: 424 RFALMNMKLALIRVLQNFS 442 >6DA2-A nrPDB Length = 487 Score = 123 bits (309), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 119/444 (26%), Positives = 190/444 (42%), Gaps = 35/444 (7%) Query: 32 PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDK 91 PGP PLP LGN+L +G + +KYG V+ + G +PV+ + + I+ LV + Sbjct: 19 PGPTPLPFLGNILSY-HKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 77 Query: 92 A-EAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEE 149 F+ R V F + A WK LR T F GK + + I + Sbjct: 78 CYSVFTNRRPFGPVG--FMKSAISIAEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQY 132 Query: 150 AQCLIEELRKSK--GALMDPTFLFQSITANIICSIVFGKRF----HYQD---QEFLKMLN 200 L+ LR+ G + +F + + ++I S FG + QD + K+L Sbjct: 133 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 192 Query: 201 L-FYQTFSLISSVFGQLFELFSGF-LKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDP 258 F F L +VF L + + FP +E+ ++ SV++ +E+ Sbjct: 193 FDFLDPFFLSITVFPFLIPILEVLNICVFP----------REVTNFLRKSVKRMKESRLE 242 Query: 259 SAPKDLIDTYLLHMEKEKSN---AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315 K +D L ++ + S +H S L ++ FAG ETTS+ L + + Sbjct: 243 DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA 302 Query: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375 +P V +++ EI+ V+ PP +M Y + V+ E R + M + + + Sbjct: 303 THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDV 361 Query: 376 SFRGYIIPKDTEVFLILSTALH-DPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434 G IPK V +I S ALH DP Y+ +P+ F P+ F N + PF G R Sbjct: 362 EINGMFIPKGV-VVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 420 Query: 435 ICLGEGIARAELFLFFTTILQNFS 458 C+G A + L +LQNFS Sbjct: 421 NCIGMRFALMNMKLALIRVLQNFS 444 >3K9V-A nrPDB Length = 482 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 109/447 (24%), Positives = 187/447 (41%), Gaps = 35/447 (7%) Query: 32 PGPRPLPLLGNLLQMDRRGLLK----SFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREA 87 PGP PLLG+LL++ +G LK + + +KYG +F + LG V L G ++ EA Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEA 85 Query: 88 LVDKAEAFSGRGKI----AMVDPFFRGYGVIFANGNRWKVLRR-FSVTTMRDFGMGKRSV 142 L A R +I A D YG++ G W+ +R F M+ + K + Sbjct: 86 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--L 143 Query: 143 EERIQEEAQCLIE---ELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199 +++I E +E EL +G + D + IC +++ KRF +E + Sbjct: 144 DKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEA 203 Query: 200 NLFYQTFSLISSVFGQLF----ELFSGFLKYFPGAHRQVYKNL-QEINAYIGHSVEKHRE 254 F + S FG++ EL AH + + + + I + ++++ + Sbjct: 204 LTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQ 263 Query: 255 TLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM 314 P A L D Y S + L L A ETT+ +L + + Sbjct: 264 --QPGA-DFLCDIY----------QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNL 310 Query: 315 LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH 374 + P R+ +E++ V+ ++ P D MPY +A + E R + +P + + Sbjct: 311 SRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKP 369 Query: 375 TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434 T Y +PK T + L FE F P+ +L + A +PF +GKR Sbjct: 370 TVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPF-AHLPFGIGKR 428 Query: 435 ICLGEGIARAELFLFFTTILQNFSMAS 461 +C+G +A +L L I+Q + + + Sbjct: 429 MCIGRRLAELQLHLALCWIIQKYDIVA 455 >3MDV-A nrPDB Length = 456 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 104/425 (24%), Positives = 180/425 (42%), Gaps = 40/425 (9%) Query: 49 RGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFF 108 R L FL + +KYG V V++ + V++ E++++ L+ + A+ F Sbjct: 10 RVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFG 69 Query: 109 R---GYGVIF-ANGNRWKVLRR-----FSVTTMRDFGMGKRSVEERIQEEAQCLIEELRK 159 G G++ N RW RR FS +++ S+ E E+A+ L+E L + Sbjct: 70 ERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLV-------SLMETFNEKAEQLVEIL-E 121 Query: 160 SKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFEL 219 +K P + Q + I+ F + L Q L+ + Sbjct: 122 AKADGQTPVSM-QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLM---LEGITAS 177 Query: 220 FSGFLKYFPGAHRQVYKNLQEIN--AYIGHS-VEKHRETLD--PSAPKDLIDTYLLHMEK 274 + K+ PG +Q+ + + I +G V++ RE L P D++ T +L E+ Sbjct: 178 RNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADIL-TQILKAEE 236 Query: 275 EKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP 334 + + L N ++ F AG ET++ L + + + + P + R+ E+++VIG Sbjct: 237 GAQD------DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGS 290 Query: 335 HRPPELHDRAKMPYTEAVIYEIQRFSDLLP--MGVPHIVTQHTSFRGYIIPKDTEVFLIL 392 R + D ++ Y V+ E R L P G ++ + T G +P +T + Sbjct: 291 KRYLDFEDLGRLQYLSQVLKESLR---LYPPAWGTFRLLEEETLIDGVRVPGNTPLLFST 347 Query: 393 STALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTT 452 YFE P FNPD F GA K + PFSLG R C+G+ A+ E+ + Sbjct: 348 YVMGRMDTYFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAK 405 Query: 453 ILQNF 457 +LQ Sbjct: 406 LLQRL 410 >3EL3-A nrPDB Length = 467 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 98/430 (22%), Positives = 174/430 (40%), Gaps = 38/430 (8%) Query: 37 LPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFS 96 +PLLG+ ++ R L +F+ +GDV + LGP+ V + E + AL + Sbjct: 31 VPLLGHGWRLARDPL--AFMSQLRDHGDVVRIKLGPKTVYAVTNPE-LTGALALNPDYHI 87 Query: 97 GRGKIAMVDPFFRGYGVIFANGNRWKVLRR-----FSVTTMRDFGMGKRSVEERIQEEAQ 151 ++ GV ANG + RR F + + +G ++EEA Sbjct: 88 AGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYG-------PIMEEEAH 140 Query: 152 CLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQE----FLKMLNLFYQTFS 207 L E R G +D T + + + R Y D+ + + +F + Sbjct: 141 ALTE--RWQPGKTVDATSESFRVAVRVAARCLL--RGQYMDERAERLCVALATVFRGMYR 196 Query: 208 LISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDT 267 + G L+ L P A+R+ L +++ + + + R + P DL+ T Sbjct: 197 RMVVPLGPLYRL------PLP-ANRRFNDALADLHLLVDEIIAERRAS--GQKPDDLL-T 246 Query: 268 YLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYRE 327 LL + + + E Q ++ +++ G+ET ++T+ + + +P A+R+ E Sbjct: 247 ALLEAKDDNGDPIGE---QEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDE 303 Query: 328 IEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTE 387 +E V G RP D K+ +T VI E R + + V + + GY IP + Sbjct: 304 VEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAE-SELGGYRIPAGAD 361 Query: 388 VFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELF 447 + DP ++ F+PD +L A A PFS GKR C + + A+L Sbjct: 362 IIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLT 421 Query: 448 LFFTTILQNF 457 L + + Sbjct: 422 LITAALATKY 431 >2VE3-A nrPDB Length = 444 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 103/441 (23%), Positives = 179/441 (40%), Gaps = 48/441 (10%) Query: 30 LPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALV 89 +PPG LP LG L G + ++++G +F L + V+ + G A R Sbjct: 13 IPPGDFGLPWLGETLNFLNDGDFGK--KRQQQFGPIFKTRLFGKNVIFISGALANRFLFT 70 Query: 90 DKAEAFSGRGKIA---MVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERI 146 + E F ++ ++ P + + +R K+L + + D S ++ Sbjct: 71 KEQETFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLD------SYLPKM 124 Query: 147 QEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEF----LKMLNLF 202 Q +E+ K+ + P + +T ++ ++ G++ Q F + LF Sbjct: 125 DGIVQGYLEQWGKANEVIWYPQL--RRMTFDVAATLFMGEKVSQNPQLFPWFETYIQGLF 182 Query: 203 YQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPK 262 L +++FG+ + R L E+ I K R+ PS + Sbjct: 183 SLPIPLPNTLFGK--------------SQRARALLLAELEKII-----KARQQQPPSE-E 222 Query: 263 DLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAE 322 D + L + + + S L L L FAG ET ++ L LL+ ++ + E Sbjct: 223 DALGILL----AARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRE 278 Query: 323 RVYREIEQVIGPHRPPELHDRA--KMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGY 380 RV +E ++ EL KMPY + V+ E+ R + G ++ Q F+G+ Sbjct: 279 RVRQEQNKL---QLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELI-QDCQFQGF 334 Query: 381 IIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFL-DANGALKKTEAFIPFSLGKRICLGE 439 PK V +S DP + P+ F+P+ F D + A +PF G R CLG+ Sbjct: 335 HFPKGWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGK 394 Query: 440 GIARAELFLFFTTILQNFSMA 460 AR E+ LF T ++Q F Sbjct: 395 EFARLEMKLFATRLIQQFDWT 415 >6C94-A nrPDB Length = 497 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 94/446 (21%), Positives = 174/446 (39%), Gaps = 32/446 (7%) Query: 32 PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDK 91 PGP L G+ L++ + G L + + +++ + P V G I E D Sbjct: 25 PGPPTHWLFGHALEIQKTGSLDKVVTWTQQFP-----YAHPLWVGQFIGFLNIYEP--DY 77 Query: 92 AEAFSGRGKIAMVDPF-----FRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERI 146 A+A RG D + + G G++ +G +W R+ +T + + K V Sbjct: 78 AKAVYSRGDPKAPDVYDFFLQWIGKGLLVLDGPKWFQHRKL-LTPGFHYDVLKPYVA-IF 135 Query: 147 QEEAQCLIEELRK--SKGALMDPTFLFQSITANIICSIVFGKR---FHYQDQEF---LKM 198 + + ++E+ K +G D + + + FGK +++D + + Sbjct: 136 ADSTRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVAVSE 195 Query: 199 LNLFYQ----TFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRE 254 L L Q +F + L FL+ AH + +++ A + EK RE Sbjct: 196 LTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAAL--QDEKERE 253 Query: 255 TLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM 314 + D +D L + + + S +L + F G +TT++ + + M Sbjct: 254 KIQNRRHLDFLDILL----DVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCM 309 Query: 315 LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH 374 YP +R E+ +++G + D AKM Y + E R +P + Sbjct: 310 ALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPV 369 Query: 375 TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434 + G +P + + L + + + P+ F+P F N + + AFIPFS G R Sbjct: 370 SFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPR 429 Query: 435 ICLGEGIARAELFLFFTTILQNFSMA 460 C+G+ A E+ + L F + Sbjct: 430 NCIGQQFAMNEMKVVTALCLLRFEFS 455 >3S79-A nrPDB Length = 503 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 49/185 (26%), Positives = 86/185 (46%), Gaps = 7/185 (3%) Query: 277 SNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHR 336 + + + +N+N L + A +T S +L + L+ K+P+V E + +EI+ VIG R Sbjct: 285 AEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ER 343 Query: 337 PPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTAL 396 ++ D K+ E IYE R+ ++ + V + GY + K T + L + + Sbjct: 344 DIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGR-M 401 Query: 397 HDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQN 456 H +F KP+ F ++F F PF G R C G+ IA + T+L+ Sbjct: 402 HRLEFFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRR 457 Query: 457 FSMAS 461 F + + Sbjct: 458 FHVKT 462 >6AYB-A nrPDB Length = 466 Score = 68.2 bits (165), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 104/482 (21%), Positives = 188/482 (39%), Gaps = 43/482 (8%) Query: 22 RHPNTHDRLPPG-PRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCG 80 + ++ +LPP P +P +G+ + + ++ + +KYGDVFT + + + L Sbjct: 3 KKTSSKGKLPPRVPNLIPYVGSFVSF-AKNPVQFIIDNSKKYGDVFTATILGKEMTFLNH 61 Query: 81 VEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFS-----VTTMRDF 135 + + S R + P F G GV++ + +++ + +TT R F Sbjct: 62 PKILDTFFKATDNELSLRDVYRFMRPVF-GTGVVYDADSTERMMEQVKFVSSGLTTAR-F 119 Query: 136 GMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITA-------NIICSIVFGKRF 188 + E+ I + + L E LM +F + + GK + Sbjct: 120 RVFVDIFEDEIAHKVKELGPEGTVDVAELMADLIIFTASRCLLGDEVRQYLSEKNLGKLY 179 Query: 189 HYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHS 248 H D + + L+ FY + A + V + QE+ Sbjct: 180 HDID-DGISPLSFFYPSLPAPKR----------------DKARKAVGEIFQELLDKRREE 222 Query: 249 VEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLR 308 +KH E L + D++D H+ +K E + + ++ FAG T+S T Sbjct: 223 HKKHPERLLDESKMDVVD----HLLTQKYKDGQELTDVHRIGILIAGLFAGQHTSSITSS 278 Query: 309 YGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVP 368 + + ++ V E+V +E E+++G + + KM Y EA + E R L M + Sbjct: 279 WTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIM-IM 337 Query: 369 HIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIP 428 + + YIIPK + + S A + PD F+P+ + K +P Sbjct: 338 RMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVP 397 Query: 429 FSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPT---YQ 485 F G+ C+GE A ++ + +L+ F M D T VG PPT Y+ Sbjct: 398 FGAGRHKCIGENFALLQVKSIISILLRYFDMEYIGKIPDPSYT--SLVVGPSPPTRMRYK 455 Query: 486 IR 487 +R Sbjct: 456 LR 457 >4YZR-A nrPDB Length = 405 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 62/271 (22%), Positives = 114/271 (42%), Gaps = 44/271 (16%) Query: 206 FSLISSVFG------QLFELFSGFLKYFPGAHRQVYKN-LQEINAYIGHSVEKHRETLDP 258 F +IS + G F++++ + +R++ L+E YI + R Sbjct: 151 FIVISELMGIPKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRR----- 205 Query: 259 SAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP 318 PKD + + L+H E+ S + S + L L AG ETT L G L +L++ Sbjct: 206 IKPKDDLISKLVHAEENGS----KLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHK 261 Query: 319 HVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378 E++ ++ E + + E+ R++ + M + +++ Sbjct: 262 KECEKLKQQPEMIA------------------TAVEELLRYTSPVVMMANRWAIEDFTYK 303 Query: 379 GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLG 438 G+ I + +F+ + +A DP++FE P+ N + + I F G CLG Sbjct: 304 GHSIKRGDMIFIGIGSANRDPNFFENPEILNIN---------RSPNRHISFGFGIHFCLG 354 Query: 439 EGIARAELFLFFTTILQNF-SMASPVAPEDI 468 +AR E + F +L+ F + VAP+DI Sbjct: 355 APLARLEGHIAFKALLKRFPDIELAVAPDDI 385 >3JUS-A nrPDB Length = 461 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 97/433 (22%), Positives = 180/433 (41%), Gaps = 44/433 (10%) Query: 36 PLPLLGNLLQMDRRGLLKSFLRFR-EKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEA 94 P+P LG+ + + + FL EKYG VF+ + + L G +A K E Sbjct: 19 PIPFLGHAIAFGKSPI--EFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNED 76 Query: 95 FSGRGKIA-MVDPFFRGYGVIFANGN-----RWKVLRRFSVTTMRDFGMGKRSVEERIQE 148 + + + P F G GV + N + K+L+ S + F +E+ +E Sbjct: 77 LNAEDVYSRLTTPVF-GKGVAYDVPNPVFLEQKKMLK--SGLNIAHFKQHVSIIEKETKE 133 Query: 149 EAQCLIEELRKSKGALMDPTFLFQSITANIICS---IVFGKRFHYQDQEFLKMLNLFYQT 205 + E K+ +F++++ II + + GK Q E + Q Sbjct: 134 YFESWGESGEKN---------VFEALSELIILTASHCLHGKEIRSQLNEKVA------QL 178 Query: 206 FSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLI 265 ++ + F L G+L P R+ + +EI +++K R++ ++ I Sbjct: 179 YADLDGGFSHAAWLLPGWLP-LPSFRRRDRAH-REIKDIFYKAIQKRRQS------QEKI 230 Query: 266 DTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVY 325 D L + + + + L AG T+STT + + + + ++ Y Sbjct: 231 DDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCY 290 Query: 326 REIEQVIGPHRPPELHDRAK-MPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPK 384 E + V G + PP +D+ K + + I E R + M + + + GY IP Sbjct: 291 LEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPI-MIMMRMARTPQTVAGYTIPP 349 Query: 385 DTEVFL--ILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIA 442 +V + ++ L D + E+ D FNPD +L N A + A++PF G+ C+GE A Sbjct: 350 GHQVCVSPTVNQRLKD-SWVERLD-FNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFA 407 Query: 443 RAELFLFFTTILQ 455 ++ ++T+L+ Sbjct: 408 YVQIKTIWSTMLR 420 >5FSA-A nrPDB Length = 490 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 107/459 (23%), Positives = 178/459 (38%), Gaps = 97/459 (21%) Query: 55 FLRFREKYGDVF---------TVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVD 105 F R+KYGDVF TV+LGP+ G E + A + A + Sbjct: 30 FESCRQKYGDVFSFMLLGKIMTVYLGPK------GHEFVFNAKLSDVSAEEAYKHLTT-- 81 Query: 106 PFFRGYGVIFANGN----RWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSK 161 P F G GVI+ N K +F++TT KR V +I+EE Sbjct: 82 PVF-GTGVIYDCPNSRLMEQKKFAKFALTT----DSFKRYVP-KIREEILNYF------- 128 Query: 162 GALMDPTFLFQSIT---ANII-----CSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVF 213 + D +F + T AN++ +I R + D+ M +F ++F+ + S Sbjct: 129 --VTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDE----MRRIFDRSFAQLYSDL 182 Query: 214 GQLFELFSGFLKYFPGAHRQVYKNLQE-INAYIGHSVEKHRETLDPSAPKDLIDTYLLHM 272 + F + P H Q+ I+A ++ RE D +DLID+ L+H Sbjct: 183 DKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKLRRERGDIDPNRDLIDSLLIHS 242 Query: 273 EKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVI 332 + ++ NL + + G T+++T + L + + PH+ + +Y+E+ +++ Sbjct: 243 TYKDGVKMTDQEIANL---LIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELL 299 Query: 333 ----GPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR---------- 378 G D K+P I E R +P+ H+ FR Sbjct: 300 KEKGGDLNDLTYEDLQKLPSVNNTIKETLRMH--MPL--------HSIFRKVTNPLRIPE 349 Query: 379 -GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDAN------------------GA 419 YI+PK V + A YF+ P+ F+P + A G Sbjct: 350 TNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGK 409 Query: 420 LKK--TEAFIPFSLGKRICLGEGIARAELFLFFTTILQN 456 + K + ++PF G+ C+GE A +L TT + N Sbjct: 410 VSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN 448 >3MZS-A nrPDB Length = 486 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 53/180 (29%), Positives = 80/180 (44%), Gaps = 14/180 (7%) Query: 286 QNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAK 345 +++ N + G TTS TL++ M + +V E + E+V+ R E D +K Sbjct: 275 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLR---EEVLNARRQAE-GDISK 330 Query: 346 M----PYTEAVIYEIQRFSDLLPMGVP--HIVTQHTSFRGYIIPKDTEVFLILSTALHDP 399 M P +A I E R L P+ V + Y+IP T V + + DP Sbjct: 331 MLQMVPLLKASIKETLR---LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDP 387 Query: 400 HYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSM 459 +F PD F+P +L + L + F G R C+G IA E+ LF IL+NF + Sbjct: 388 AFFSSPDKFDPTRWLSKDKDLIHFRN-LGFGWGVRQCVGRRIAELEMTLFLIHILENFKV 446 >1Q5D-A nrPDB Length = 419 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 51/191 (26%), Positives = 78/191 (40%), Gaps = 31/191 (16%) Query: 267 TYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYR 326 T LL E + S S + L ++ AGT+TT + + L +L+ P E V Sbjct: 227 TMLLQAEADGSR----LSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKA 282 Query: 327 EIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDT 386 E P L A + E+ RF ++L +G Q + G I K Sbjct: 283 E----------PGLMRNA--------LDEVLRFDNILRIGTVRFARQDLEYCGASIKKGE 324 Query: 387 EVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAEL 446 VFL++ +AL D F +PD F+ + T A + + G +C G +AR E Sbjct: 325 MVFLLIPSALRDGTVFSRPDVFD---------VRRDTSASLAYGRGPHVCPGVSLARLEA 375 Query: 447 FLFFTTILQNF 457 + TI + F Sbjct: 376 EIAVGTIFRRF 386 >3N9Z-A nrPDB Length = 487 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 49/183 (26%), Positives = 79/183 (43%), Gaps = 14/183 (7%) Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 S+ S +++ N + G +TTS TL++ M + V + + E+ R Sbjct: 269 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAA----RHQAQ 324 Query: 341 HDRAKM----PYTEAVIYEIQRFSDLLPMGVP--HIVTQHTSFRGYIIPKDTEVFLILST 394 D A M P +A I E R L P+ V + R Y+IP T V + + Sbjct: 325 GDMATMLQLVPLLKASIKETLR---LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYA 381 Query: 395 ALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTIL 454 +P +F P+ F+P +L + + + F G R CLG IA E+ +F +L Sbjct: 382 LGREPTFFFDPENFDPTRWLSKDKNITYFRN-LGFGWGVRQCLGRRIAELEMTIFLINML 440 Query: 455 QNF 457 +NF Sbjct: 441 ENF 443 >4KPA-A nrPDB Length = 494 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 100/449 (22%), Positives = 167/449 (37%), Gaps = 54/449 (12%) Query: 32 PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDK 91 P P+ L NL ++ +++ ++ ++ G++F R L I+EA D+ Sbjct: 30 PQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEA-CDE 88 Query: 92 AEAFSGRGKIAMVDPFFRGYGVI--FANGNRWK-----VLRRFSVTTMR-------DFGM 137 + + F G G+ + + WK +L FS M+ D + Sbjct: 89 SRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAV 148 Query: 138 GKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLK 197 ER+ + + E D T L T + I F RF Sbjct: 149 QLVQKWERLNADEHIEVPE---------DMTRL----TLDTIGLCGFNYRF--------- 186 Query: 198 MLNLFY--QTFSLISSVFGQLFELFSGFLKYFPG--AHRQVYKNLQEINAYIGHSVEKHR 253 N FY Q I+S+ L E + + P A+ + + QE + V+K Sbjct: 187 --NSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKI- 243 Query: 254 ETLDPSAPKDLIDTYLLHMEKEKSNAHSE-FSHQNLNLNTLSLFFAGTETTSTTLRYGFL 312 D A + D L HM K E +N+ ++ AG ETTS L + Sbjct: 244 -IADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALY 302 Query: 313 LMLKYPHVAERVYREIEQV-IGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIV 371 ++K PHV ++ E +V + P P ++ Y V+ E R P Sbjct: 303 FLVKNPHVLQKAAEEAARVLVDP--VPSYKQVKQLKYVGMVLNEALRLWPTAP-AFSLYA 359 Query: 372 TQHTSFRG-YIIPKDTEVFLILSTALHDPHYF-EKPDAFNPDHFLDANGALKKTEAFIPF 429 + T G Y + K E+ +++ D + + + F P+ F N + AF PF Sbjct: 360 KEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERF--ENPSAIPQHAFKPF 417 Query: 430 SLGKRICLGEGIARAELFLFFTTILQNFS 458 G+R C+G+ A E L +L++F Sbjct: 418 GNGQRACIGQQFALHEATLVLGMMLKHFD 446 >2WX2-A nrPDB Length = 473 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 91/437 (20%), Positives = 172/437 (39%), Gaps = 34/437 (7%) Query: 31 PPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVD 90 P P +P LG+++Q + L R+ VFT+ +G + V ++ Sbjct: 19 PVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSP 78 Query: 91 KAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEE 149 + E S R ++ P F G GV +A + +R + + K ++ IQ E Sbjct: 79 RNEILSPREVYTIMTPVF-GEGVAYAAP--YPRMREQLNFLAEELTIAKFQNFVPAIQHE 135 Query: 150 AQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGK--RFHYQDQEFLKMLNLFYQTFS 207 + + E K +++ ++ N C +FG+ R + F ++L+ S Sbjct: 136 VRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMES--S 193 Query: 208 LISSVFGQLFELFSGFLKYFP----GAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKD 263 LI + +F +L P R+ LQ+I I + EK + D + D Sbjct: 194 LIPAA------VFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNT-SD 246 Query: 264 LIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML--KYPHVA 321 L+ L + ++ + S + ++ FAG T++ T + L ++ K Sbjct: 247 LLGGLLKAVYRDGTR----MSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWL 302 Query: 322 ERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYI 381 +++++EI++ + D +MP+ E + E R L M V +V Y+ Sbjct: 303 DKLHKEIDEFPAQLNYDNVMD--EMPFAERCVRESIRRDPPLLM-VMRMVKAEVKVGSYV 359 Query: 382 IPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGI 441 +PK + + HD F P ++P+ +GA FI F G C+G+ Sbjct: 360 VPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGA------FIGFGAGVHKCIGQKF 413 Query: 442 ARAELFLFFTTILQNFS 458 A ++ T + + Sbjct: 414 ALLQVKTILATAFREYD 430 >4OQS-A nrPDB Length = 433 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 64/259 (24%), Positives = 103/259 (39%), Gaps = 48/259 (18%) Query: 233 QVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNT 292 +V L ++ YI V R +PKD + L+ ++ + + L Sbjct: 188 EVTTALGKLTRYIAELVATKR-----LSPKDDLLGSLI--------TDTDLTDEELTNIA 234 Query: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 352 L L AG ETT+ L G +L++P EQ+ P Sbjct: 235 LLLLVAGHETTANMLGLGTFALLQHP----------EQIAALDSP-------------DA 271 Query: 353 IYEIQRFSDLLPMGVPH-IVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPD 411 + E+ R+ ++ +G P+ + G +I K V + L DP F++PD D Sbjct: 272 VEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLD 331 Query: 412 HFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF-SMASPVAPEDIDL 470 +DA +K AF G CLG+ +AR E+ + FT + F S+ V E+I L Sbjct: 332 R-VDA----RKHAAF---GGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKL 383 Query: 471 TPQEC--GVGKIPPTYQIR 487 + GV +P + R Sbjct: 384 REKSAAYGVWALPVAWDAR 402 >2W0A-A nrPDB Length = 455 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 89/417 (21%), Positives = 166/417 (39%), Gaps = 37/417 (8%) Query: 57 RFREKYGDVFTVHLGPRPVVMLCGVEAIR------EALVDKAEAFSGRGKIAMVDPFFRG 110 R R++ GDV T L + VV+L G A + +D+A+A+ + P F G Sbjct: 32 RVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYP------FMTPIF-G 84 Query: 111 YGVIF-ANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTF 169 V+F A+ R K + +R M + I+++ + +I + + +D Sbjct: 85 EAVVFDASPERRKEM--LHNAALRGEQMKGHAAT--IEDQVRRMIADW--GEAGEIDLLD 138 Query: 170 LFQSITANIICSIVFGKRFHYQ-DQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFP 228 F +T + + GK+F Q D F K+ + + ++ V L F + Sbjct: 139 FFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYL--PIESFRRRDE 196 Query: 229 GAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNL 288 + V +N I + + +D++D L+ ++ E FS + Sbjct: 197 ARNGLVALVADIMNGRIANPPTD-------KSDRDMLDV-LIAVKAETGT--PRFSADEI 246 Query: 289 NLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPY 348 +S+ FAG T+S T + + ++++ V E++++ G R H ++P Sbjct: 247 TGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQ 306 Query: 349 TEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAF 408 E V+ E R L + + + +G+ I + V + + P F P F Sbjct: 307 LENVLKETLRLHPPLII-LMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDF 365 Query: 409 NPDHFLDANGA-LKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQ--NFSMASP 462 P + L +IPF G+ C+G A ++ F+ +L+ F MA P Sbjct: 366 VPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQP 422 >4OQR-A nrPDB Length = 457 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 63/257 (24%), Positives = 102/257 (39%), Gaps = 48/257 (18%) Query: 233 QVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNT 292 +V L ++ YI V R +PKD + L+ ++ + + L Sbjct: 227 EVTTALGKLTRYIAELVATKR-----LSPKDDLLGSLI--------TDTDLTDEELTNIA 273 Query: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 352 L L AG ETT+ L G +L++P EQ+ P Sbjct: 274 LILLVAGHETTANMLGLGTFALLQHP----------EQIANLDSP-------------DA 310 Query: 353 IYEIQRFSDLLPMGVPH-IVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPD 411 + E+ R+ ++ +G P+ + G +I K V + L DP F++PD D Sbjct: 311 VEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLD 370 Query: 412 HFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF-SMASPVAPEDIDL 470 +DA +K AF G CLG+ +AR E+ + FT + F S+ V E+I L Sbjct: 371 R-VDA----RKHAAF---GGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKL 422 Query: 471 TPQEC--GVGKIPPTYQ 485 + GV +P + Sbjct: 423 REKSAAYGVWALPVAWD 439 >5JLC-A nrPDB Length = 515 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 96/452 (21%), Positives = 169/452 (37%), Gaps = 74/452 (16%) Query: 59 REKYGDVF---------TVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFR 109 ++KYGD+F TV+LGP+ G E I A + A + + P F Sbjct: 66 QKKYGDIFSFMLLGRIMTVYLGPK------GHEFIFNAKLADVSAEAAYSHLTT--PVF- 116 Query: 110 GYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKG------- 162 G GVI+ N R + K + + A+ + + R SK Sbjct: 117 GKGVIYDCPNH----RLMEQKKFVKGALTKEAFVRYVPLIAEEIYKYFRNSKNFKINENN 172 Query: 163 -ALMDPTFLFQSITANIICSIVFGKRFHYQ-DQEFLKMLNLFYQTFSLISSVFGQLFELF 220 ++D +T + GK + D +F + + + F+ I+ VF L Sbjct: 173 SGIVDVMVSQPEMTIFTASRSLLGKEMRDKLDTDFAYLYSDLDKGFTPINFVFPNL---- 228 Query: 221 SGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAH 280 P H + + Q+ + S+ K R + +DLID M+ Sbjct: 229 -------PLEHYRKRDHAQQAISGTYMSLIKERREKNDIQNRDLIDEL---MKNSTYKDG 278 Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 ++ + Q + + + G T++ T + L + + P V E +Y+E +V+ + EL Sbjct: 279 TKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLN-NDTKEL 337 Query: 341 --HDRAKMPYTEAVIYEIQRFS----DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILST 394 D MP +I E R L + + +TS Y++P+D V + Sbjct: 338 TYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTS---YVVPRDYHVLVSPGY 394 Query: 395 ALHDPHYFEKPDAFNPDHFLDAN----------------GALKK--TEAFIPFSLGKRIC 436 +F KP+ FN H D + GA+ K + ++PF G+ C Sbjct: 395 THLQEEFFPKPNEFNI-HRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRC 453 Query: 437 LGEGIARAELFLFFTTILQNFSMASPVAPEDI 468 +GE A +L + + ++ P E + Sbjct: 454 IGELFAYCQLGVLMSIFIRTMKWRYPTEGETV 485 >3NC3-A nrPDB Length = 441 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 44/166 (26%), Positives = 64/166 (38%), Gaps = 20/166 (12%) Query: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 352 L++ A TE TL +L P V L DR+ +P Sbjct: 264 LNVLLAATEPADKTLALMIYHLLNNPEQMNDV---------------LADRSLVPRA--- 305 Query: 353 IYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPD- 411 I E R+ + + +P ++Q T G I KDT VF ++ A DP FE+PD FN Sbjct: 306 IAETLRYKPPVQL-IPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHR 364 Query: 412 HFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 L A + F G C+G A+ E+ + +L Sbjct: 365 EDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKM 410 >3TYW-A nrPDB Length = 417 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 41/169 (24%), Positives = 73/169 (43%), Gaps = 28/169 (16%) Query: 290 LNTLSLFF-AGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPY 348 L+TL + AG ETT++ + LL+L P + + ++ P+L MP Sbjct: 240 LSTLGITINAGRETTTSMIALSTLLLLDRPELPAELRKD----------PDL-----MPA 284 Query: 349 TEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAF 408 + + +D +P+ + + G +P D V +L+ A HDP F+ P+ Sbjct: 285 AVDELLRVLSVADSIPL---RVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERV 341 Query: 409 NPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 + H D + + F G C+G+ +AR EL + T+L+ Sbjct: 342 D-FHRTDNH--------HVAFGYGVHQCVGQHLARLELEVALETLLRRV 381 >3MGX-A nrPDB Length = 415 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 70/320 (21%), Positives = 114/320 (35%), Gaps = 65/320 (20%) Query: 140 RSVEERIQEEAQCLIEELRKSKGALMDP-TFLFQSITANIICSIVFGKRFHYQDQEFLKM 198 R + ER++ E ++ R G + D T + I A ++C I+ +D++ L Sbjct: 131 RKLAERVRIEVGDVLG--RVLDGEVCDAATAIGPRIPAAVVCEILG---VPAEDEDML-- 183 Query: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDP 258 L + FG ELF G RQ + EI Y + R+ +P Sbjct: 184 -------IDLTNHAFGGEDELFDGMTP------RQAHT---EILVYFDELITARRK--EP 225 Query: 259 SAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP 318 DL+ T + + + ++ LN ++ G ETT + + P Sbjct: 226 G--DDLVSTLV---------TDDDLTIDDVLLNCDNVLIGGNETTRHAITGAVHALATVP 274 Query: 319 HVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378 + + R + V+ E+ R++ M V + T + Sbjct: 275 GLLTAL------------------RDGSADVDTVVEEVLRWTSP-AMHVLRVTTADVTIN 315 Query: 379 GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLG 438 G +P T V L A DP F+ PD F P +K I F G CLG Sbjct: 316 GRDLPSGTPVVAWLPAANRDPAEFDDPDTFLPG---------RKPNRHITFGHGMHHCLG 366 Query: 439 EGIARAELFLFFTTILQNFS 458 +AR EL + + + S Sbjct: 367 SALARIELSVVLRVLAERVS 386 >3EJB-B nrPDB Length = 404 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 46/194 (23%), Positives = 75/194 (38%), Gaps = 34/194 (17%) Query: 262 KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVA 321 +D+I L EK+K + + + L AG ETT + L +L++P Sbjct: 204 QDMISMLLKGREKDK------LTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHP--- 254 Query: 322 ERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYI 381 EQ++ P+L A + E R+ M + ++ G Sbjct: 255 -------EQLLKLRENPDLIGTA--------VEECLRYESPTQM-TARVASEDIDICGVT 298 Query: 382 IPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGI 441 I + +V+L+L A DP F PD F+ + + F G +CLG + Sbjct: 299 IRQGEQVYLLLGAANRDPSIFTNPDVFD---------ITRSPNPHLSFGHGHHVCLGSSL 349 Query: 442 ARAELFLFFTTILQ 455 AR E + T+LQ Sbjct: 350 ARLEAQIAINTLLQ 363 >6M7X-A nrPDB Length = 484 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 38/161 (23%), Positives = 68/161 (42%), Gaps = 6/161 (3%) Query: 280 HSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPE 339 ++E S + N++ L +TT L + + P+V + + +E Sbjct: 273 NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 332 Query: 340 LHDRAKMPYTEAVIYEIQRFSDLLPMGV--PHIVTQHTSFRGYIIPKDTEVFLILSTALH 397 ++P A + E R L P+G+ + + + Y IP T V + L + Sbjct: 333 QKATTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGR 389 Query: 398 DPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLG 438 +P F +P+ +NP +LD G+ + +PF G R CLG Sbjct: 390 NPALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLG 429 >4UBS-A nrPDB Length = 393 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 66/271 (24%), Positives = 109/271 (40%), Gaps = 41/271 (15%) Query: 217 FELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEK 276 FE S L PG +V +++ Y+ +++ R K+ D L + +E+ Sbjct: 161 FESQSRRLLRGPGIA-EVQDARAQLDDYLYALIDRKR--------KEPGDGLLDDLIQEQ 211 Query: 277 SNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHR 336 N + + ++L TL L AG ETT+ + G +L++P EQ+ Sbjct: 212 LNRGTVDRAELVSLATL-LLIAGHETTANMISLGTFTLLRHP----------EQLAELRA 260 Query: 337 PPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTAL 396 P L MP A + E+ RF + G+ + T+ G I D V S Sbjct: 261 EPGL-----MP---AAVEELLRFLSIAD-GLLRVATEDIEVAGTTIRADEGVVFATSVIN 311 Query: 397 HDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQN 456 D F +PDA + + + F G CLG+ +ARAE+ + T+ + Sbjct: 312 RDAAGFAEPDALD---------WHRSARHHVAFGFGIHQCLGQNLARAEMEIALGTLFER 362 Query: 457 FSMASPVAPED-IDLTPQEC--GVGKIPPTY 484 AP D I P + G+ ++P T+ Sbjct: 363 LPGLRLAAPADEIPFKPGDTIQGMLELPVTW 393 >6M7L-A nrPDB Length = 404 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 76/198 (38%), Gaps = 31/198 (15%) Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 ++ S + L + + E T + L G LL+L++P EQ PEL Sbjct: 227 ADISDEELAGLCAVVMNSSVEQTESCLAAGTLLLLEHP----------EQFALLRERPEL 276 Query: 341 HDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPH 400 ++A + EI R+ + P T+ G +I K VF L A Sbjct: 277 GEQA--------VEEIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAA----- 323 Query: 401 YFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF-SM 459 D LD +K + F G CLG +AR EL + FTT++ F S+ Sbjct: 324 -------NRADPALDGFDITRKESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRFPSL 376 Query: 460 ASPVAPEDIDLTPQECGV 477 + V E+I P V Sbjct: 377 RTAVPAEEIRFRPPSSNV 394 >6FYJ-A nrPDB Length = 421 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 13/116 (11%) Query: 335 HRPPELHDRAK---MPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLI 391 H PE ++ K Y++ + E++RF P V +V + +++GY + T L Sbjct: 263 HHYPEEKEKLKSGDKKYSQMFVQEVRRFYPFFPFVVA-LVKKDFTWKGYKFEEGTLTLLD 321 Query: 392 LSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIP-----FSLGKRICLGEGIA 442 L HDP ++ PD F+PD F G+ +FIP + +G R C GE + Sbjct: 322 LYGTNHDPEIWKNPDVFSPDRFAKWEGS---PFSFIPQGGGDYFMGHR-CAGEWVT 373 >4ZGX-A nrPDB Length = 489 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 38/160 (23%), Positives = 68/160 (42%), Gaps = 6/160 (3%) Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 +E S + + N++ L +TT+ L + + P V + + +E Sbjct: 274 AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ 333 Query: 341 HDRAKMPYTEAVIYEIQRFSDLLPMGV--PHIVTQHTSFRGYIIPKDTEVFLILSTALHD 398 ++P A + E R L P+G+ +V+ + Y IP T V + L + + Sbjct: 334 KATTELPLLRAALKETLR---LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRN 390 Query: 399 PHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLG 438 F +P+ +NP +LD G+ + +PF G R CLG Sbjct: 391 AALFPRPERYNPQRWLDIRGSGRNFH-HVPFGFGMRQCLG 429 >3P3Z-A nrPDB Length = 416 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/163 (26%), Positives = 63/163 (38%), Gaps = 28/163 (17%) Query: 286 QNLNLNTL--SLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDR 343 + L TL ++ AG ETT+ L ++P +Q + PEL + Sbjct: 239 DDYELRTLVATVLVAGYETTNHQLALAMYDFAQHP----------DQWMKIKENPELAPQ 288 Query: 344 AKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFE 403 A + E+ R+S LP+ + + G IP T VF+ A DP F Sbjct: 289 A--------VEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFA 340 Query: 404 KPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAEL 446 D F+ +K+ I F G CLG +AR EL Sbjct: 341 DADRFDI--------TVKREAPSIAFGGGPHFCLGTALARLEL 375 >5IT1-A nrPDB Length = 399 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 42/173 (24%), Positives = 70/173 (40%), Gaps = 30/173 (17%) Query: 294 SLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVI 353 +L A +TT+ + G L+L P +Q+ + P L A + Sbjct: 233 TLLIAAHDTTACMIGLGTALLLDRP----------DQLALLQKDPSLIGNA--------V 274 Query: 354 YEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHF 413 E+ R+ + G + TQ G I K +V L +A DP + E P+ F+ Sbjct: 275 EELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFD---- 330 Query: 414 LDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF---SMASPV 463 ++ + F G C+G+ +AR EL + F T+ + F +A PV Sbjct: 331 -----ITRRPAPHLAFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKPV 378 >5LIE-A nrPDB Length = 414 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 42/183 (22%), Positives = 69/183 (37%), Gaps = 28/183 (15%) Query: 295 LFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIY 354 LF AG ETT ++ G L + + P + + + E + I Sbjct: 250 LFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFELL------------------PTAIE 291 Query: 355 EIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFL 414 EI R++ P ++ S G I +V + +A DP F++ D F+ Sbjct: 292 EIVRWTSPSP-SKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFD----- 345 Query: 415 DANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQE 474 +K + F G CLG +AR EL + F +L F V P + + + Sbjct: 346 ----ITRKPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEPAEWTRSNRH 401 Query: 475 CGV 477 G+ Sbjct: 402 TGI 404 >2ZBZ-A nrPDB Length = 412 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 48/213 (22%), Positives = 82/213 (38%), Gaps = 38/213 (17%) Query: 279 AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP--HVAERVYREIEQVIGPHR 336 A+ E + L + L AG ETT++ + +L +P + A R Sbjct: 225 ANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRA------------ 272 Query: 337 PPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTAL 396 DR+ +P + E+ R+ + + + T G +I V ++ S A Sbjct: 273 -----DRSLVP---GAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIAN 324 Query: 397 HDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQ- 455 D +E PDA + + + F G CLG+ +AR EL + ++ Sbjct: 325 RDGTVYEDPDALD---------IHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDR 375 Query: 456 --NFSMASPVAPEDIDLTPQEC--GVGKIPPTY 484 +A PV E + L P GV ++P T+ Sbjct: 376 VPTLRLAVPV--EQLVLRPGTTIQGVNELPVTW 406 >4GGV-A nrPDB Length = 418 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 61/274 (22%), Positives = 96/274 (35%), Gaps = 46/274 (16%) Query: 215 QLFELFSGF-LKYFPGAHRQVYKNLQE-----INAYIGHSVEKHRETLDPSAPKDLIDTY 268 + E FSGF G Q ++ E ++ GH E+ R P++ Sbjct: 178 DIIEGFSGFSFLDTSGQGEQDVRDATERLRPLLDYMAGHVTERRR------TPRE---DL 228 Query: 269 LLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREI 328 L H+ + + + ++ +N+ + L G TT+ TL L + P VA +V Sbjct: 229 LTHLVQAEVDGERLTDNEIVNVANI-LLVTGHITTTMTLGNTVLCLDADPEVAAKVR--- 284 Query: 329 EQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEV 388 DR+ +P + S L G ++ G +IPKD V Sbjct: 285 ------------ADRSLVPGAIEEALRVLSPSAALARGT----SREVEVAGTVIPKDQIV 328 Query: 389 FLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFL 448 L L DP F P+ ++P + F G CLG +AR E + Sbjct: 329 MLWLGAGNRDPRQFTDPEVYDP---------TRDPNPHFGFGRGIHFCLGAPLARLEGRV 379 Query: 449 FFTTILQNFSM--ASPVAPEDIDLTPQECGVGKI 480 + F + P P TP GV + Sbjct: 380 ALNALFDRFPVLRTDPAKPPTFFPTPDMIGVNTL 413 >1WIY-A nrPDB Length = 389 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 47/200 (23%), Positives = 76/200 (38%), Gaps = 32/200 (16%) Query: 266 DTYLLHMEKEKSNAHSEFSH---QNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAE 322 D L+ E E H SH + ++L AG ET ++ L + FLL+ P + Sbjct: 186 DRGALYREAEALIVHPPLSHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQK 245 Query: 323 RVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYII 382 RV E+ + F + L + P + R ++ Sbjct: 246 RV------------------------AESEEAALAAFQEALRLYPPAWILTRRLERPLLL 281 Query: 383 PKD---TEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 439 +D L+LS + YF + +AF P+ FL G + + PF LG+R+CLG Sbjct: 282 GEDRLPQGTTLVLSPYVTQRLYFPEGEAFQPERFLAERGT--PSGRYFPFGLGQRLCLGR 339 Query: 440 GIARAELFLFFTTILQNFSM 459 A E + + F + Sbjct: 340 DFALLEGPIVLRAFFRRFRL 359 >6B11-A nrPDB Length = 440 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 40/181 (22%), Positives = 72/181 (39%), Gaps = 28/181 (15%) Query: 283 FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHD 342 SH ++ N + L AG ETT++ + L++L++P +RE+ + P P Sbjct: 264 LSHADVLDNAVLLLAAGHETTASMVTMSVLVLLQHPT----AWREL--TVNPGLLP---- 313 Query: 343 RAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYF 402 + E+ R+ + G+ T G+ I + +L+ A D F Sbjct: 314 --------GAVDELLRYLSIAD-GLRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVF 364 Query: 403 EKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462 +P+AF+ + + F G CLG+ +AR EL + +L+ P Sbjct: 365 SEPEAFD---------IHRSARRHVAFGYGPHQCLGQNLARMELEVALGAVLERLPALRP 415 Query: 463 V 463 Sbjct: 416 T 416 >5HDI-A nrPDB Length = 404 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 45/187 (24%), Positives = 68/187 (36%), Gaps = 27/187 (14%) Query: 273 EKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVI 332 E + A E + ++LF AG E+T+ L ++ P + ++V Sbjct: 219 ELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQV-------- 270 Query: 333 GPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLIL 392 RA A I E R+ H V T+ G +P D+ + L+ Sbjct: 271 ----------RANPELLGAFIEETLRYEPPFRGHYRH-VRNATTLDGTELPADSHLLLLW 319 Query: 393 STALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTT 452 A DP FE P F D A G + I F G C+G +AR E + Sbjct: 320 GAANRDPAQFEAPGEFRLDR---AGG-----KGHISFGKGAHFCVGAALARLEARIVLRL 371 Query: 453 ILQNFSM 459 +L S+ Sbjct: 372 LLDRTSV 378 >5Z9I-A nrPDB Length = 398 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 71/213 (33%), Gaps = 35/213 (16%) Query: 280 HSEFSHQNLNLNTLS-----LFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP 334 H+E Q LN + +S L G TT+ + L + + RV Sbjct: 214 HAEVDGQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCLDAFSDQDARV---------- 263 Query: 335 HRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILST 394 RA A++ E R+ + GV G +IPKD + + Sbjct: 264 --------RADRSLVPALLEESMRYMSPI-CGVGRATNSEVEVAGTVIPKDQLLLVWTGA 314 Query: 395 ALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTIL 454 A D FEKPD F+ A + A + F G CLG +AR E +L Sbjct: 315 ANRDERQFEKPDVFD---------AGRSPNAHLGFGRGIHFCLGRQLARMESKAAVEILL 365 Query: 455 QNFSM--ASPVAPEDIDLTPQECGVGKIPPTYQ 485 A P P GV +P Q Sbjct: 366 DRLPTLRADPANPPTFLQVVDASGVATLPVVTQ 398 >6GK6-A nrPDB Length = 411 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 71/301 (23%), Positives = 111/301 (36%), Gaps = 61/301 (20%) Query: 171 FQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFEL-------FSGF 223 Q I +I +++ D+ ++++ F F L ++V +L L F + Sbjct: 122 IQEIADGLIDAVI--------DRRRMELIADF--AFPLPTAVIAELLGLPVEDRGRFRRW 171 Query: 224 LKYF--PGAHRQVYKNLQ----EINAYIGHSVEKHRETLDPSAPKD-LIDTYLLHMEKEK 276 K P R+ + Q E AY + R+ AP+D LI LL E+E Sbjct: 172 TKILLAPAKDREFVERAQPVVEEFAAYFRALADARRK-----APRDDLISGLLLAEEQEH 226 Query: 277 SNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHR 336 + +E S L AG ETT + G LL+L +P AER R +++ G Sbjct: 227 KLSPAELSSM-----VFLLLVAGHETTVHLIASGMLLLLSHP--AER--RRLDEDPG--- 274 Query: 337 PPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTAL 396 + + E R + + G +P V L A Sbjct: 275 -----------LVGSAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAAN 323 Query: 397 HDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQN 456 DP +F PD F+ + I F G CLG +AR E + F+T+L+ Sbjct: 324 RDPQHFPDPDRFD---------IGRSPNRHIGFGGGIHFCLGAMLARIEAAIAFSTLLRR 374 Query: 457 F 457 Sbjct: 375 L 375 >3ABB-A nrPDB Length = 408 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 40/169 (23%), Positives = 65/169 (38%), Gaps = 34/169 (20%) Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 + H + + L L AG ETT + G L ++++P + + R+ V G Sbjct: 226 GDLDHDEVVMIALVLLVAGHETTVNAIALGALTLIQHPEQIDVLLRDPGAVSG------- 278 Query: 341 HDRAKMPYTEAVIYEIQRFSDLLPMGVPHIV---TQHTSFRGYIIPKDTEVFLILSTALH 397 V+ E+ RF+ + HIV + G I V + ++ Sbjct: 279 -----------VVEELLRFTSV----SDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNR 323 Query: 398 DPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAEL 446 D +E PD F+ A + + F G CLG+ +ARAEL Sbjct: 324 DAKAYENPDIFD---------ARRNARHHVGFGHGIHQCLGQNLARAEL 363 >6CR2-A nrPDB Length = 477 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 42/174 (24%), Positives = 68/174 (39%), Gaps = 22/174 (12%) Query: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDR-AKMPYTEA 351 ++L AG ++S+T + L + P + E +Y+E +V+G PP +D K+ Sbjct: 256 IALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAK 315 Query: 352 VIYEIQRFSDLLPMGVPHIVTQHTSFRG--YIIPKDTEVFLILSTALHDPHYFEKPDAFN 409 VI E R + + V + G Y+IP V +F P +N Sbjct: 316 VIKETLRLHAPI-HSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWN 374 Query: 410 PDHFLDANGALKKTE-----------------AFIPFSLGKRICLGEGIARAEL 446 P H D N A + ++PF G+ C+GE A +L Sbjct: 375 P-HRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQL 427 >2Y5N-A nrPDB Length = 417 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 53/247 (21%), Positives = 92/247 (37%), Gaps = 46/247 (18%) Query: 217 FELFSG-FLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKE 275 F +SG FL ++ + ++ AY+G +++ R+ P D + + L+ + Sbjct: 181 FTRWSGAFLSTAEVTAEEMQEAAEQAYAYMGDLIDRRRKE-----PTDDLVSALVQARDQ 235 Query: 276 KSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLR-YGFLLMLKYPHVAERVYREIEQVIGP 334 + + S Q L + L AG E+T+T + + +LLM + Sbjct: 236 QDS----LSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTR------------------ 273 Query: 335 HRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGV----PHIVTQHTSFRGYIIPKDTEVFL 390 PEL R + E + ++ + +P+GV P + + RG I V Sbjct: 274 ---PELR-RQLLDRPELIPSAVEELTRWVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLA 329 Query: 391 ILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFF 450 A D F D + D + + F G CLG +AR EL + Sbjct: 330 STGAANRDQAQFPDADRIDVD---------RTPNQHLGFGHGVHHCLGAPLARVELQVAL 380 Query: 451 TTILQNF 457 +LQ Sbjct: 381 EVLLQRL 387 >5EX6-C nrPDB Length = 434 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 53/259 (20%), Positives = 95/259 (36%), Gaps = 34/259 (13%) Query: 230 AHRQVYKNLQ-EINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNL 288 HR + +L A G + ++ T+ KD D + + E + + + L Sbjct: 206 CHRHLDASLSGRRRAAAGEAFSRYLVTMVARERKDPGDGLIGMVVAEHGDT---VTDEEL 262 Query: 289 NLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPY 348 + + AG + S + G L +L+ P EQ+ R +P Sbjct: 263 RGVCVQMMLAGDDNISGMIGLGVLALLRNP----------EQIAAL--------RGDVPA 304 Query: 349 TEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAF 408 E + E+ R+ + P + ++ +I V L TA DP PDA Sbjct: 305 AERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALL--PDAD 362 Query: 409 NPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF---SMASPVAP 465 D ++ + F G CLG +AR EL + +T + + F +A P Sbjct: 363 RLD-------VTREAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADPDGA 415 Query: 466 EDIDLTPQECGVGKIPPTY 484 + L+ G+ ++ T+ Sbjct: 416 TEFRLSTPAYGISRLMVTW 434 >5FYF-A nrPDB Length = 470 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 39/168 (23%), Positives = 63/168 (37%), Gaps = 27/168 (16%) Query: 291 NTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTE 350 N L G +TT ++ G + M ++P RE E++ +AK Sbjct: 300 NLTLLIVGGNDTTRNSMSGGLVAMNEFP-------REFEKL-----------KAKPELIP 341 Query: 351 AVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNP 410 ++ EI R+ L + I Q G I K V + ++ D F+ PD F Sbjct: 342 NMVSEIIRWQTPLAY-MRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFII 400 Query: 411 DHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 458 D K + F G C+G +A +L + + IL+ F Sbjct: 401 DR--------KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFD 440 >5FOI-A nrPDB Length = 408 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 43/181 (23%), Positives = 71/181 (39%), Gaps = 28/181 (15%) Query: 266 DTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVY 325 DT LL + E +HQ L N + L AG ET++ + L +L++P A + Sbjct: 215 DTGLLGTAVTERLLKGEITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELR 274 Query: 326 REIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKD 385 + PEL MP + E+ R+ + G+ T + I Sbjct: 275 EQ----------PEL-----MPN---AVDELLRYHSIAD-GLRRAATADIVLGDHTIRAG 315 Query: 386 TEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAE 445 + ++LS+A HD + F F+ + + F G CLG+ +AR E Sbjct: 316 DGLIILLSSANHDGNTFGAEATFD---------IHRPARHHVAFGYGPHQCLGQNLARLE 366 Query: 446 L 446 + Sbjct: 367 M 367 >4WPZ-A nrPDB Length = 397 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 48/226 (21%), Positives = 82/226 (36%), Gaps = 39/226 (17%) Query: 244 YIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETT 303 Y G + RE P D + + L+ + S+ S + + + ++ + AG ETT Sbjct: 187 YFGELIAVKREN-----PADDLISELIAI----SDGDSTLTEREIIALSIGILSAGHETT 237 Query: 304 STTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLL 363 + + + +L P +++ +R +P + E+ RF L Sbjct: 238 ANQISMFLVTLLHNPEELDKLR---------------DNREAIPKA---VDELLRFVPLT 279 Query: 364 PMG--VPHIVTQHTSFRG-YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420 G +P + T G ++P V ++TA DP FE + N Sbjct: 280 TTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLN---------VT 330 Query: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPE 466 ++ + F G CLG +AR EL IL PE Sbjct: 331 RENNPHLAFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPE 376 >4DO1-A nrPDB Length = 410 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 42/178 (23%), Positives = 73/178 (41%), Gaps = 38/178 (21%) Query: 294 SLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVI 353 SL AG +TT + + ++P +R+ + P L A+ + EAV Sbjct: 245 SLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSD----------PTL---ARNAFEEAVR 291 Query: 354 YE--IQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPD 411 +E +Q F T+ G +I + +V + L +A DP + PD ++ Sbjct: 292 FESPVQTFF--------RTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYD-- 341 Query: 412 HFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDID 469 +KT + F G +C+G+ +AR E + + ++A VA DID Sbjct: 342 -------ITRKTSGHVGFGSGVHMCVGQLVARLEGEVMLS------ALARKVAAIDID 386 >2Z36-A nrPDB Length = 413 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 53/252 (21%), Positives = 91/252 (36%), Gaps = 39/252 (15%) Query: 236 KNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSL 295 + E+ AYI + + S P D D + + +++ H L L Sbjct: 192 RAFAELRAYIDDLITRKE-----SEPGD--DLFSRQIARQRQEG--TLDHAGLVSLAFLL 242 Query: 296 FFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYE 355 AG ETT+ + G + +L +P V P R P + E Sbjct: 243 LTAGHETTANMISLGVVGLLSHPEQLTVVK------ANPGRTP------------MAVEE 284 Query: 356 IQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLD 415 + R+ + + T+ G I V + + +A DP F+ P + + Sbjct: 285 LLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVE---- 340 Query: 416 ANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF-SMASPVAPEDIDLTPQE 474 + + F G CLG+ +AR EL + F T+ + S+ V ED+ Sbjct: 341 -----RGARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAVPMEDVPFKGDS 395 Query: 475 C--GVGKIPPTY 484 GV ++P T+ Sbjct: 396 VIYGVHELPVTW 407 >2VZM-A nrPDB Length = 436 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 49/248 (19%), Positives = 90/248 (36%), Gaps = 36/248 (14%) Query: 227 FPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQ 286 FP Q + E++ Y+ ++ R +DL+ + +++ S SE + Sbjct: 200 FPDDPAQAQTAMAEMSGYLSRLIDSKRG----QDGEDLLSALVRTSDEDGSRLTSE---E 252 Query: 287 NLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKM 346 L + + L AG ETT + G +L +P + RA M Sbjct: 253 LLGMAHI-LLVAGHETTVNLIANGMYALLSHPDQLAAL------------------RADM 293 Query: 347 PYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPD 406 + + E+ R+ + + G +IP V ++L+ A P F P Sbjct: 294 TLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPH 353 Query: 407 AFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF-SMASPVAP 465 F+ + T + F G C+G +AR E + +L+ +A V+P Sbjct: 354 RFD---------IRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSP 404 Query: 466 EDIDLTPQ 473 ++ P Sbjct: 405 GELVWYPN 412 >6G5O-A nrPDB Length = 399 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 48/199 (24%), Positives = 76/199 (38%), Gaps = 36/199 (18%) Query: 296 FFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYE 355 F G +T + + ++P ER+ +E PE+ RA V Sbjct: 218 FAGGRDTVINAVTNSIAYLAEHPEALERLRKE----------PEITGRA-------VEEM 260 Query: 356 IQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLD 415 I+ FS L MG +VT+ T + + D+ + L ++A D FE P+ D Sbjct: 261 IRYFSPLTQMG--RVVTEDTHVCEHAVKADSRISLCWASANRDAAVFENPNEIVLD---- 314 Query: 416 ANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS----MASPVAPEDIDLT 471 +K + F CLG AR L + T+ Q + + ED+D Sbjct: 315 -----RKVNPHVGFGFSHHNCLGATHARQILKILLQTLAQKVASFEILDYKENIEDLDHF 369 Query: 472 PQECGVGKIPPTYQIRFLP 490 ++ G I QI+F P Sbjct: 370 QRKVGFHNI----QIKFNP 384 >3L4D-A nrPDB Length = 453 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 87/434 (20%), Positives = 174/434 (40%), Gaps = 42/434 (9%) Query: 38 PLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSG 97 P +G+++Q + L L+ ++KYG +FT+++ + ++ V + + E S Sbjct: 13 PFVGHIIQFGKDPL-GFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSKFFTPRNEILSP 71 Query: 98 RGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEEAQCLIEE 156 R + + P F G GV +A + +R + + K ++ IQ E + ++ Sbjct: 72 REVYSFMVPVF-GEGVAYAAP--YPRMREQLNFLAEELTVAKFQNFAPSIQHEVRKFMKA 128 Query: 157 LRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNL--FYQTFSLISSVFG 214 ++ ++ N C +FG ++ K L+ F Q + + S Sbjct: 129 NWNKDEGEINILDDCSAMIINTACQCLFG-------EDLRKRLDARQFAQLLAKMESCLI 181 Query: 215 QLFELFSGFLKY-FPGAHR--QVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLH 271 LK P ++R LQ+I + I + EK D + DL+ L Sbjct: 182 PAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNT-SDLLAGLLGA 240 Query: 272 MEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML---KYPHVAERVYREI 328 + ++ + S + ++ FAG T++ T + L ++ H+A ++++EI Sbjct: 241 VYRDGT----RMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLA-KLHQEI 295 Query: 329 EQVIGPHRPPEL-HDRA--KMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKD 385 ++ P +L +D +MP+ E E R L M + V + Y++P+ Sbjct: 296 DEF-----PAQLNYDNVMEEMPFAEQCARESIRRDPPLVM-LMRKVLKPVQVGKYVVPEG 349 Query: 386 TEVFLILSTALHDPHYFEKPDAFNPDHFLD-ANGALKKTEAFIPFSLGKRICLGEGIARA 444 + + D F P +NP+ + +GA F F G C+GE Sbjct: 350 DIIACSPLLSHQDEEAFPNPREWNPERNMKLVDGA------FCGFGAGVHKCIGEKFGLL 403 Query: 445 ELFLFFTTILQNFS 458 ++ T+L+++ Sbjct: 404 QVKTVLATVLRDYD 417 >3ABA-A nrPDB Length = 403 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 39/173 (22%), Positives = 68/173 (39%), Gaps = 30/173 (17%) Query: 294 SLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVI 353 +L A +TT+ + G L+L P + RE ++G + Sbjct: 233 TLLIAAHDTTACMIGLGTALLLDSPDQLA-LLREDPSLVG-----------------NAV 274 Query: 354 YEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHF 413 E+ R+ + G + T+ G I K +V + A DP + E+P+ F+ Sbjct: 275 EELLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFD---- 330 Query: 414 LDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTI---LQNFSMASPV 463 ++ + F G C+G+ +AR EL + F T+ L +A PV Sbjct: 331 -----ITRRPAPHLAFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPV 378 >6G71-A nrPDB Length = 405 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 12/97 (12%) Query: 351 AVIYEIQRFSDLLPMG-VPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFN 409 AV E R+ + P+G VP T GY IP+ ++ L + +A D + PD F+ Sbjct: 271 AVFEESIRW--VAPIGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFD 328 Query: 410 PDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAEL 446 + + +EA + F G +CLG AR+++ Sbjct: 329 IE---------RGSEAHLAFGKGVHVCLGAWAARSQV 356 >2XKR-A nrPDB Length = 398 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 43/176 (24%), Positives = 70/176 (39%), Gaps = 30/176 (17%) Query: 283 FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHD 342 S L + TL + G ETT TL G E++ R +Q R P L Sbjct: 215 LSDDELVMETLLILIGGDETTRHTLSGG----------TEQLLRNRDQWDLLQRDPSL-- 262 Query: 343 RAKMPYTEAVIYEIQRFSDLLPM-GVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 401 +P I E+ R++ P+ + ++T T F G + ++ L+ +A D Sbjct: 263 ---LP---GAIEEMLRWT--APVKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAV 314 Query: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 F +P+ F+ + + + F G CLG +AR EL L +L+ Sbjct: 315 FCEPEKFD---------VQRNPNSHLAFGFGTHFCLGNQLARLELSLMTERVLRRL 361 >5YHJ-A nrPDB Length = 413 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 44/168 (26%), Positives = 72/168 (42%), Gaps = 17/168 (10%) Query: 312 LLMLKYPHVAERVYREIEQVIGPHRPPELHD---RAKMPYTEAVIYEIQRFSDLLPMGVP 368 +L + P VA VY + V+ H+ P++ + R ++ TE + E++RF P+ Sbjct: 234 VLNILRPTVAISVYV-LFTVLALHQFPDVKEQVERGEVSKTE-FVQEVRRFYPFFPVAAA 291 Query: 369 HIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIP 428 + T + GY P+ T L L HD + +PD F+P F D + FIP Sbjct: 292 RVKTDF-EWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRFKDWK---ESPFNFIP 347 Query: 429 -----FSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLT 471 G R C GE + A L + ++ P P+D+ + Sbjct: 348 QGGGDVDFGHR-CAGEHVTIAILAQVIELFTKEYAYTVP--PQDLSYS 392 >3SN5-A nrPDB Length = 491 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 80/225 (35%), Gaps = 36/225 (16%) Query: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHV----AERVYREIE---QVIGPHRPP------E 339 L + +A T + M++ P E V R +E Q + P E Sbjct: 263 LVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAE 322 Query: 340 LHDRAKMPYTEAVIYEIQRFSD--LLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALH 397 L+D +P +++I E R S L T H Y I KD + L Sbjct: 323 LND---LPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHL 379 Query: 398 DPHYFEKPDAFNPDHFLDANGALKKT---------EAFIPFSLGKRICLGEGIARAELFL 448 DP + P F D +LD NG K T ++PF G IC G A E+ Sbjct: 380 DPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQ 439 Query: 449 FFTTILQNFSM-----ASPVAPEDIDLTPQECGVGKIPPTYQIRF 488 F +L F + + P L G+G +PP I F Sbjct: 440 FLILMLSYFELELIEGQAKCPP----LDQSRAGLGILPPLNDIEF 480 >4TRI-A nrPDB Length = 407 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 43/199 (21%), Positives = 76/199 (38%), Gaps = 32/199 (16%) Query: 259 SAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP 318 + P D + + L++ E E S + TL + G ETT TL G +L++ Sbjct: 198 AEPTDDLFSVLVNSEVEGQ----RMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHR 253 Query: 319 HVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378 + + +++ + G I E+ R++ + + +T T F Sbjct: 254 DQWDALVADVDLLPG------------------AIEEMLRWTSPVK-NMCRTLTADTVFH 294 Query: 379 GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLG 438 G + ++ L+ +A D F PD F D + + + F G CLG Sbjct: 295 GTELRAGEKIMLMFESANFDESVFGDPDNFRID---------RNPNSHVAFGFGTHFCLG 345 Query: 439 EGIARAELFLFFTTILQNF 457 +AR EL L +L+ Sbjct: 346 NQLARLELRLMTERVLRRL 364 >5CJE-A nrPDB Length = 393 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 70/334 (20%), Positives = 119/334 (35%), Gaps = 65/334 (19%) Query: 126 RFSVTTMRDFGMGK-RSVEERIQEEAQCLIEE-LRKSKGALMDPTFLFQSITANIICSIV 183 R R F M + ++ RIQE L++E L + + L+D +F + + +IC Sbjct: 93 RLRSLVARAFTMRRVEALRPRIQEITDGLLDEMLPRGRADLVD-SFAY-PLPITVIC--- 147 Query: 184 FGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINA 243 E L + ++ TF +S+ E+ + P + + A Sbjct: 148 ----------ELLGVPDIDRVTFRALSN------EIVA------PTGGDAELAAYERLAA 185 Query: 244 YIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETT 303 Y+ ++ R T AP D + L+ E + S + L L AG ETT Sbjct: 186 YLDELIDDKRST----APADDLLGDLIRTRAEDDD---RLSGEELRAMAFILLVAGHETT 238 Query: 304 STTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLL 363 + G +L +P + RA M + + E+ RF + Sbjct: 239 VNLITNGVHTLLTHPDQLAAL------------------RADMTLLDGAVEEVLRFEGPV 280 Query: 364 PMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPD-HFLDANGALKK 422 + G I + V + L A DP A +PD H D + + Sbjct: 281 ETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDP-------ARHPDPHVFDIH---RA 330 Query: 423 TEAFIPFSLGKRICLGEGIARAELFLFFTTILQN 456 + + F G CLG +AR E + ++L+ Sbjct: 331 PQGHLAFGHGIHYCLGAPLARLEARVALRSLLER 364 >2WM5-A nrPDB Length = 435 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 43/189 (22%), Positives = 71/189 (37%), Gaps = 39/189 (20%) Query: 271 HMEKEKSNAHSEFSHQNLNLNTLSLFF-----AGTETTSTTLRYGFLLMLKYPHVAERVY 325 H + S +E + L+ ++ FF AG ETT + +G L + +YP +R + Sbjct: 242 HDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYPEQRDRWW 301 Query: 326 REIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKD 385 + + + P E+ + + V+Y + +TQ RG + Sbjct: 302 SDFDG-LAPTAVEEI-----VRWASPVVY------------MRRTLTQDIELRGTKMAAG 343 Query: 386 TEVFLILSTALHDPHYFEKPDAF----NPDHFLDANGALKKTEAFIPFSLGKRICLGEGI 441 +V L +A D F P F NP+ L G G CLG + Sbjct: 344 DKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGG------------GAHFCLGANL 391 Query: 442 ARAELFLFF 450 AR E+ + F Sbjct: 392 ARREIRVAF 400 >4WMZ-A nrPDB Length = 539 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 92/446 (20%), Positives = 162/446 (36%), Gaps = 53/446 (11%) Query: 55 FLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIA-MVDPFFRGYGV 113 F ++KYGD+F+ L R + + G + K S A + P F G GV Sbjct: 80 FEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVF-GKGV 138 Query: 114 IFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKG--------ALM 165 I+ N R + K + + + A+ + + R SK + Sbjct: 139 IYDCPNS----RLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTI 194 Query: 166 DPTFLFQSITANIICSIVFGKRFHYQ-DQEFLKMLNLFYQTFSLISSVFGQLFELFSGFL 224 D +T + GK + D +F + + + F+ I+ VF L Sbjct: 195 DVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNL-------- 246 Query: 225 KYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFS 284 P H + + Q+ + S+ K R + +DLID+ M+ + + Sbjct: 247 ---PLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSL---MKNSTYKDGVKMT 300 Query: 285 HQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDR- 343 Q + + + G T++ T + L + + P V + +Y E +V+ + +D Sbjct: 301 DQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLL 360 Query: 344 AKMPYTEAVIYEIQRFSDLLPMGVPHIVTQ-HTSFRGYIIPKDTEVFLILS-TALHDPHY 401 +MP I E R L ++ H Y+IP V + T L D Y Sbjct: 361 QEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRD-EY 419 Query: 402 FEKPDAFNPDHFLDAN--------------GALKK--TEAFIPFSLGKRICLGEGIARAE 445 F FN + + + GA+ K + ++PF G+ C+GE A + Sbjct: 420 FPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQ 479 Query: 446 L----FLFFTTILQNFSMASPVAPED 467 L +F T+ ++ V P D Sbjct: 480 LGVLMSIFIRTLKWHYPEGKTVPPPD 505 >1LG9-A nrPDB Length = 398 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 45/203 (22%), Positives = 75/203 (36%), Gaps = 30/203 (14%) Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 + + + L + + AG + S + G L ML++P + +R EQ Sbjct: 219 DDATDEELRGFCVQVMLAGDDNISGMIGLGVLAMLRHPEQID-AFRGDEQ---------- 267 Query: 341 HDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPH 400 + + E+ R+ + P I + + G I K V L A DP Sbjct: 268 -------SAQRAVDELIRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDP- 319 Query: 401 YFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF--- 457 A PD +D ++ + F G CLG +AR EL FT + + F Sbjct: 320 ------ALAPD--VDRLDVTREPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPAL 371 Query: 458 SMASPVAPEDIDLTPQECGVGKI 480 +A P + LT G+ ++ Sbjct: 372 RLADPAQDTEFRLTTPAYGLTEL 394 >5Y1I-A nrPDB Length = 403 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 43/178 (24%), Positives = 68/178 (38%), Gaps = 25/178 (14%) Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 E + + + L AG ETT+ + G L +L+ P EQ+ E+ Sbjct: 220 GEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENP----------EQLA------EV 263 Query: 341 HDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPH 400 D + E+ R+ + V I + G +I + L+ A DP Sbjct: 264 RDSDDPKVIVNTVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPD 323 Query: 401 -YFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 Y E PD LD + A + F G CLG +AR EL + ++T+L+ Sbjct: 324 LYPEAPDR------LDIHRA--NARRHLAFGYGVHQCLGATLARVELQIVYSTLLRRI 373 >5NWS-A nrPDB Length = 435 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/194 (20%), Positives = 74/194 (38%), Gaps = 23/194 (11%) Query: 264 LIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAER 323 L D L + + + + S L+L AG ET++ + G +L +P Sbjct: 233 LTDDLLSELIRAQDDDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWAL 292 Query: 324 VYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIP 383 + ++ P L RA ++E+ R+ + + T+ G + Sbjct: 293 LRKD----------PALLPRA--------VHELMRWCGSVHVARLRYATEDLELAGTPVA 334 Query: 384 KDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIAR 443 + V L+L +A DP ++ PD + + + E + F G CLG +AR Sbjct: 335 RGDAVQLVLVSANFDPRHYSDPDRLDITRHQEG-----QAENHVGFGHGIHYCLGATLAR 389 Query: 444 AELFLFFTTILQNF 457 E + +L+ + Sbjct: 390 QEGEVALARLLETY 403 >3A1L-A nrPDB Length = 425 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/177 (24%), Positives = 67/177 (37%), Gaps = 28/177 (15%) Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 S S + + L AG ETT+ L L + R +R++ + Sbjct: 237 SPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTL--------RAHRDVLDEL-------- 280 Query: 341 HDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPH 400 R T A + E+ R+ D V + + IP+ + V +L +A DP Sbjct: 281 --RTTPESTPAAVEELMRY-DPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPA 337 Query: 401 YFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 F PD LD + A ++ + F LG CLG +ARAE + +L Sbjct: 338 RFPDPD------VLDVHRAAERQ---VGFGLGIHYCLGATLARAEAEIGLRALLDGI 385 >5L94-A nrPDB Length = 410 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 49/228 (21%), Positives = 88/228 (38%), Gaps = 39/228 (17%) Query: 231 HRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNL 290 ++ K E+ Y +E+ R + P D I + LL ++E + + + + Sbjct: 184 QQEKMKANDELETYFYRIIEEKR-----TRPGDDIISVLLQAKEE----GKQLTDEEIVG 234 Query: 291 NTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTE 350 ++ L AG ETT+ + +++ ER+ RE E +P Sbjct: 235 FSILLLIAGNETTTNLISNTIYCLMEDKASFERLKREKEL---------------LP--- 276 Query: 351 AVIYEIQRFSDLLPMGVPH-IVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFN 409 + I E+ R+ P+ H IV + + G + V + +A D YFE P+ F Sbjct: 277 SGIEEVLRYRS--PVQALHRIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFK 334 Query: 410 PDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 D +K + F G CLG +AR E + ++ + Sbjct: 335 ID---------RKPNVHMAFGRGIHFCLGAPLARIEAKIMLAELIDRY 373 >2FR7-A nrPDB Length = 412 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/167 (22%), Positives = 66/167 (39%), Gaps = 32/167 (19%) Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 E + + L SL AG +TT + + ++P R+ + P L Sbjct: 234 GEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRAD----------PSL 283 Query: 341 HDRAKMPYTEAVIYE--IQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHD 398 A+ + EAV +E +Q F T+ G I + +V + L +A D Sbjct: 284 ---ARNAFEEAVRFESPVQTFF--------RTTTRDVELAGATIGEGEKVLMFLGSANRD 332 Query: 399 PHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAE 445 P ++ PD ++ +KT + F G +C+G+ +AR E Sbjct: 333 PRRWDDPDRYD---------ITRKTSGHVGFGSGVHMCVGQLVARLE 370 >6CVC-A nrPDB Length = 433 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 43/206 (20%), Positives = 79/206 (38%), Gaps = 41/206 (19%) Query: 271 HMEKEKSNAHSEFSHQNLNLNTLSLFF-----AGTETTSTTLRYGFLLMLKYPHVAERVY 325 H + S +E + L+ + +++FF AG ETT + +G L + +YP + + Sbjct: 239 HGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNAISHGMLALSRYPDERAKWW 298 Query: 326 REIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKD 385 + + + + EI R++ + + + ++Q RG + Sbjct: 299 SDFDGLAA-----------------TAVEEIVRWASPV-VYMRRTLSQDVDLRGTKMAAG 340 Query: 386 TEVFLILSTALHDPHYFEKPDAF----NPDHFLDANGALKKTEAFIPFSLGKRICLGEGI 441 +V L +A D F P F NP+ + G G CLG + Sbjct: 341 DKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGG------------GAHFCLGANL 388 Query: 442 ARAELFLFFTTILQNFSMASPVAPED 467 AR E+ + F + + M VA E+ Sbjct: 389 ARREIRVVFDELRRQ--MPDVVATEE 412 >3R9C-A nrPDB Length = 418 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 39/166 (23%), Positives = 57/166 (34%), Gaps = 28/166 (16%) Query: 295 LFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIY 354 L AG ETT + L ML+ P + A AVI Sbjct: 253 LLIAGHETTVNLIANAALAMLRTPGQWAALA------------------ADGSRASAVIE 294 Query: 355 EIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFL 414 E R+ + + V + + +PK + L+L+ A DP PD F+PD Sbjct: 295 ETMRYDPPVQL-VSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPD--- 350 Query: 415 DANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMA 460 + + F G CLG +AR E + + F A Sbjct: 351 ------RAQIRHLGFGKGAHFCLGAPLARLEATVALPALAARFPEA 390 >4RM4-A nrPDB Length = 396 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 44/183 (24%), Positives = 71/183 (38%), Gaps = 33/183 (18%) Query: 295 LFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIY 354 L AG ETT+ + +L+ P V E + PEL +A + Sbjct: 236 LLVAGNETTTNLISNAMYSILETPGVYEELRSH----------PELMPQA--------VE 277 Query: 355 EIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFL 414 E RF P+ + I + T G++I + V +++A D F++P F+ Sbjct: 278 EALRFRAPAPV-LRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFD----- 331 Query: 415 DANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQE 474 + I F G CLG +AR E + T+++ F E + +TP E Sbjct: 332 ----IRRHPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHM-----ECVSITPIE 382 Query: 475 CGV 477 V Sbjct: 383 NSV 385 >5DE9-A nrPDB Length = 410 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 44/179 (24%), Positives = 66/179 (36%), Gaps = 35/179 (19%) Query: 295 LFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIY 354 L G E + F L+L P +AER+ E PE+ RA I Sbjct: 238 LLQIGGEAVTNNSGQMFHLLLSRPELAERLRSE----------PEIRPRA--------ID 279 Query: 355 EIQRFSDLLP----MGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNP 410 E+ R+ +P +G+ I + +G I V++ A DP F PD + Sbjct: 280 ELLRW---IPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDF 336 Query: 411 DHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF-SMASPVAPEDI 468 + + + F G C G +AR E L +L + VAPED+ Sbjct: 337 E---------RSPNPHVSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDV 386 >3IVY-A nrPDB Length = 433 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 51/233 (21%), Positives = 84/233 (36%), Gaps = 57/233 (24%) Query: 256 LDPSAPKDLIDTYLLHMEKEKSNA----------HSEFSHQNLNLNTLSLFF-----AGT 300 +DP A + Y + M +EK+ ++ + L+ + F AG Sbjct: 211 IDPKASSAELIGYAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGN 270 Query: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360 ETT ++ G + ++P E +Y+++ RP E EI R++ Sbjct: 271 ETTRNSITQGMMAFAEHPDQWE-LYKKV-------RP------------ETAADEIVRWA 310 Query: 361 DLLPMGVPHIVTQHTSFRGY-----IIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLD 415 P Q T+ R Y I K V + +A D F+ P FN Sbjct: 311 ------TPVTAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFN------ 358 Query: 416 ANGALKKTEAFIPFS-LGKRICLGEGIARAELFLFFTTILQNFSMASPV-APE 466 L+ + F G C+G +AR + L F + + P+ APE Sbjct: 359 ---ILRNPNPHVGFGGTGAHYCIGANLARMTINLIFNAVADHMPDLKPISAPE 408 >1UED-A nrPDB Length = 406 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 35/164 (21%), Positives = 61/164 (37%), Gaps = 27/164 (16%) Query: 294 SLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVI 353 +L G ET + + +G L +L P E ++ E+ E V+ Sbjct: 241 ALILGGVETVAGMIGFGVLALLDNPGQIELLFESPEK------------------AERVV 282 Query: 354 YEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHF 413 E+ R+ + P + + G +I V + A D PD Sbjct: 283 NELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPD------V 336 Query: 414 LDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 LDAN + + + F G C+G +AR+ L + + T+ + F Sbjct: 337 LDAN---RAAVSDVGFGHGIHYCVGAALARSMLRMAYQTLWRRF 377 >2RFC-A nrPDB Length = 343 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 36/157 (22%), Positives = 66/157 (42%), Gaps = 15/157 (9%) Query: 302 TTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSD 361 T ++Y LL++ + + +VI + P++ D A + + E R+ Sbjct: 174 TMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDEN--PDIIDDA-LKNRSGFVEETLRYYS 230 Query: 362 LLPMGVPHIVTQHTSF-RGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420 + +PH S+ I K +V + L +A D +F++PD F + Sbjct: 231 PIQF-LPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLF----------KI 279 Query: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 + E + F +G +CLG +AR E + IL +F Sbjct: 280 GRREMHLAFGIGIHMCLGAPLARLEASIALNDILNHF 316 >5OFQ-A nrPDB Length = 409 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 51/196 (26%), Positives = 74/196 (37%), Gaps = 35/196 (17%) Query: 295 LFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIY 354 L AG ETT+ + G M + V V R+I V P L + Sbjct: 238 LLVAGNETTTNLITNGVRYMTEDVDVQNEVRRDISLV------PNL------------VE 279 Query: 355 EIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFL 414 E R+ + + I + I + +V ++A D FE PD F Sbjct: 280 ETLRYYPPI-QAIGRIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTF------ 332 Query: 415 DANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQN--FSMASPVAPEDIDLTP 472 +KT + F G CLG +AR E + FT +L+ FS + + ID +P Sbjct: 333 ---VVHRKTNPHVSFGFGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPID-SP 388 Query: 473 QECGVGKIPPTYQIRF 488 GV K Y+I F Sbjct: 389 FVFGVKK----YEIAF 400 >1Z8P-A nrPDB Length = 404 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 49/232 (21%), Positives = 82/232 (35%), Gaps = 36/232 (15%) Query: 214 GQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHME 273 G+ S L P Q + +E+ +I VE+ R + P D + + L+ ++ Sbjct: 165 GEFGRWSSEILVMDPERAEQRGQAAREVVNFILDLVERRR-----TEPGDDLLSALIRVQ 219 Query: 274 KEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIG 333 + S L L L AG E++ + + G L+L +P V R Sbjct: 220 DDDDG---RLSADELTSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVRR------- 269 Query: 334 PHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILS 393 D + +P + EI R+ P + G IP+ + V + Sbjct: 270 --------DPSALPNA---VEEILRYI-APPETTTRFAAEEVEIGGVAIPQYSTVLVANG 317 Query: 394 TALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAE 445 A DP F P F+ + T + F G C+G +A+ E Sbjct: 318 AANRDPKQFPDPHRFD---------VTRDTRGHLSFGQGIHFCMGRPLAKLE 360 >2X2N-A nrPDB Length = 475 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 37/167 (22%), Positives = 68/167 (40%), Gaps = 11/167 (6%) Query: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVA--ERVYREIEQVIGPHRPPELHDRAKMPYTE 350 ++ FAG T+S T + L ++ +V E + +EIE+ + D +MP+ E Sbjct: 272 VAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNYNNVMD--EMPFAE 329 Query: 351 AVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNP 410 E R L M + ++ Y++PK + + HD F +P ++P Sbjct: 330 RCARESIRRDPPLLMLMRKVMAD-VKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDP 388 Query: 411 DHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 + GA FI F G C+G+ ++ T +++ Sbjct: 389 ERDEKVEGA------FIGFGAGVHKCIGQKFGLLQVKTILATAFRSY 429 >2WIO-A nrPDB Length = 431 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 53/230 (23%), Positives = 86/230 (37%), Gaps = 35/230 (15%) Query: 228 PGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQN 287 P ++ L + AY+ + R DP DLI +L + + + + Sbjct: 200 PALAERIADVLNPLTAYLKARCAERRA--DPG--DDLISRLVL----AEVDGRALDDEEA 251 Query: 288 LNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMP 347 N +T +L AG TT+ L + ++P H D ++P Sbjct: 252 ANFST-ALLLAGHITTTVLLGNIVRTLDEHPA---------------HWDAAAEDPGRIP 295 Query: 348 YTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDA 407 A++ E+ R+ P + T+ T G IP D V + +A D + PD Sbjct: 296 ---AIVEEVLRYRPPFPQ-MQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDR 351 Query: 408 FNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 F+P + GA A + F G CLG +AR E + I+ F Sbjct: 352 FDPSR--KSGGA-----AQLSFGHGVHFCLGAPLARLENRVALEEIIARF 394 >5DQN-A nrPDB Length = 426 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 45/179 (25%), Positives = 62/179 (34%), Gaps = 42/179 (23%) Query: 295 LFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIY 354 L AG ETT ++ +G + + P E +E RP E Sbjct: 248 LAVAGNETTRNSITHGMIAFAQNPDQWELYKKE--------RP------------ETAAD 287 Query: 355 EIQRFSDLLPMGVPHIVTQHTSFR-----GYIIPKDTEVFLILSTALHDPHYFEKPDAFN 409 EI R++ P Q T+ G I K V + +A D FE P FN Sbjct: 288 EIVRWA------TPVSAFQRTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFN 341 Query: 410 PDHFLDANGALKKTEAFIPFS-LGKRICLGEGIARAELFLFFTTILQNFSMASPV-APE 466 L+ + F G C+G +AR + L F I N P+ APE Sbjct: 342 ---------ILRSPNPHVGFGGTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAPE 391 >4MM0-A nrPDB Length = 399 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 46/227 (20%), Positives = 83/227 (36%), Gaps = 48/227 (21%) Query: 246 GHSVEKHRETLDPSAPKDLIDTYLLHMEKEK---------------SNAHSEFSHQNLNL 290 G+S+E D +A +D +++YL + K + +E + ++ Sbjct: 175 GYSME------DWTAARDALESYLDGLVAAKRENPGSDLLSALVATAAEDNELTDHDVRS 228 Query: 291 NTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTE 350 +L L AG E S L L +L++P + R D +P Sbjct: 229 LSLILLLAGYEPASNQLGSSVLTLLRFPDRLAELRR---------------DPGLLP--- 270 Query: 351 AVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNP 410 + + E+ R++ + + + + IP ++ V A DP F+ P Sbjct: 271 SAVEELMRYAPAGDGALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRL 330 Query: 411 DHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 D + + AL G CLG +AR EL + +L+ F Sbjct: 331 DRPDNQHTALGH---------GIHFCLGAALARVELQVAIGALLRRF 368 >1UE8-A nrPDB Length = 367 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 25/105 (23%), Positives = 42/105 (40%), Gaps = 9/105 (8%) Query: 365 MGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTE 424 M + + R +I + V + +++A D F+ PD+F PD + Sbjct: 255 MRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPD---------RTPN 305 Query: 425 AFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDID 469 + F G +CLG +AR E + + F + V E ID Sbjct: 306 PHLSFGSGIHLCLGAPLARLEARIALEEFAKKFRVKEIVKKEKID 350 >5XJN-A nrPDB Length = 455 Score = 37.4 bits (85), Expect = 0.016, Method: Compositional matrix adjust. Identities = 38/150 (25%), Positives = 61/150 (40%), Gaps = 27/150 (18%) Query: 294 SLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVI 353 SL FAG ETT+T + F ++L +P EQ P+L +P A + Sbjct: 288 SLLFAGHETTTTLISNCFRVLLDHP----------EQWQAILENPKL-----IP---AAV 329 Query: 354 YEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHF 413 E+ R+S + +G + T G I + V L++ +A D FE + F+ Sbjct: 330 DEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDI--- 385 Query: 414 LDANGALKKTEAFIPFSLGKRICLGEGIAR 443 + + F G CLG +A+ Sbjct: 386 -----SRANAREHLSFGFGIHYCLGNMLAK 410 >2WIY-A nrPDB Length = 394 Score = 37.4 bits (85), Expect = 0.016, Method: Compositional matrix adjust. Identities = 22/86 (25%), Positives = 36/86 (41%), Gaps = 7/86 (8%) Query: 372 TQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSL 431 T+ G +I + + ++ A DP F+ PD F DH + + F L Sbjct: 288 TEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVF--DHTRPPAASRN-----LSFGL 340 Query: 432 GKRICLGEGIARAELFLFFTTILQNF 457 G C G+ I+RAE F + + + Sbjct: 341 GPHSCAGQIISRAEATTVFAVLAERY 366 >5GWE-A nrPDB Length = 405 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 38/150 (25%), Positives = 61/150 (40%), Gaps = 27/150 (18%) Query: 294 SLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVI 353 SL FAG ETT+T + F ++L +P EQ P+L +P A + Sbjct: 238 SLLFAGHETTTTLISNCFRVLLDHP----------EQWQAILENPKL-----IP---AAV 279 Query: 354 YEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHF 413 E+ R+S + +G + T G I + V L++ +A D FE + F+ Sbjct: 280 DEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDI--- 335 Query: 414 LDANGALKKTEAFIPFSLGKRICLGEGIAR 443 + + F G CLG +A+ Sbjct: 336 -----SRANAREHLSFGFGIHYCLGNMLAK 360 >1CPT-A nrPDB Length = 428 Score = 37.0 bits (84), Expect = 0.019, Method: Compositional matrix adjust. Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 9/80 (11%) Query: 375 TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434 T RG I + + L +A D F PD F+ F + + + F G Sbjct: 325 TEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRFPNRH---------LGFGWGAH 375 Query: 435 ICLGEGIARAELFLFFTTIL 454 +CLG+ +A+ E+ +FF +L Sbjct: 376 MCLGQHLAKLEMKIFFEELL 395 >1EHE-A nrPDB Length = 403 Score = 36.6 bits (83), Expect = 0.023, Method: Compositional matrix adjust. Identities = 30/129 (23%), Positives = 50/129 (38%), Gaps = 12/129 (9%) Query: 353 IYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDH 412 + E+ R+ + + + ++ + + +A D FE PD FN + Sbjct: 276 VEELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNR 335 Query: 413 FLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF---SMASPVAPEDID 469 L F G C+ E +A+AEL F+T+ Q F +A P+ I+ Sbjct: 336 KWPPQDPLG-------FGFGDHRCIAEHLAKAELTTVFSTLYQKFPDLKVAVPLG--KIN 386 Query: 470 LTPQECGVG 478 TP VG Sbjct: 387 YTPLNRDVG 395 >3WVS-A nrPDB Length = 401 Score = 36.6 bits (83), Expect = 0.026, Method: Compositional matrix adjust. Identities = 48/222 (21%), Positives = 82/222 (36%), Gaps = 43/222 (19%) Query: 240 EINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAG 299 E+ YIG + R + P D + + ++ E + + + Q L + + L AG Sbjct: 192 ELVGYIGGIIAARR-----AQPADDLISGMI----EARDVQDKLTEQELLDHCIGLLIAG 242 Query: 300 TETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRF 359 ETT++ + +L P +R+ + PEL + + E+ RF Sbjct: 243 HETTASQIPSFVYALLDQPQHWKRLLDD----------PEL--------IPSAVEELFRF 284 Query: 360 SDLLPMG----VPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLD 415 +P+G P + G ++ V + L A D FE P+ D Sbjct: 285 ---VPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLD---- 337 Query: 416 ANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 + + I F G CLG +AR EL +L+ Sbjct: 338 -----RPSNHHIGFGHGIHHCLGAPLARLELQEALRALLERL 374 >2X9P-A nrPDB Length = 404 Score = 36.2 bits (82), Expect = 0.031, Method: Compositional matrix adjust. Identities = 39/185 (21%), Positives = 65/185 (35%), Gaps = 26/185 (14%) Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 E + + + L FAG ++ ++ + G +L+ +P +Q P++ Sbjct: 224 GELTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHP----------DQRAAALADPDV 273 Query: 341 HDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPH 400 RA E V+ + +LP P ++ F G I V L D Sbjct: 274 MARA----VEEVLRTARAGGSVLP---PRYASEDMEFGGVTIRAGDLVLFDLGLPNFDER 326 Query: 401 YFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMA 460 F P+ F+ A + + F G C+G +AR EL FT + Sbjct: 327 AFTGPEEFD---------AARTPNPHLTFGHGIWHCIGAPLARLELRTMFTKLFTRLPEL 377 Query: 461 SPVAP 465 P P Sbjct: 378 RPELP 382 >3AWQ-A nrPDB Length = 415 Score = 35.8 bits (81), Expect = 0.046, Method: Compositional matrix adjust. Identities = 29/99 (29%), Positives = 42/99 (42%), Gaps = 10/99 (10%) Query: 348 YTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDA 407 Y E + E++RF P V +Q + G P+ +V L L + HD + P Sbjct: 273 YAELFVQEVRRFYPFFPAVVAR-ASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQE 331 Query: 408 FNPDHFLDANGALKKTEAFIPFS-----LGKRICLGEGI 441 F P+ F + + + FIP LG R C GE I Sbjct: 332 FRPERFRAWD---EDSFNFIPQGGGDHYLGHR-CPGEWI 366 >5YSW-A nrPDB Length = 441 Score = 35.0 bits (79), Expect = 0.080, Method: Compositional matrix adjust. Identities = 53/242 (21%), Positives = 95/242 (39%), Gaps = 44/242 (18%) Query: 233 QVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNT 292 + KN + A++ V R +P+ D+I + H + + E +N+ Sbjct: 221 EAVKNADALRAFMQALVTDKRA--NPAG--DIISGLIHHAGADPALTDDEL----INIAN 272 Query: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEA- 351 L L AG +TT++ L G ++L+ RP +L P A Sbjct: 273 L-LLIAGYDTTASMLGLGIFVLLQ-------------------RPAQLATLRDDPSRIAD 312 Query: 352 VIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPD 411 + E+ R+ ++ G+ + F G IP + V + + D ++ PD Sbjct: 313 AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDPD----- 367 Query: 412 HFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQ---NFSMASPVAPEDI 468 LD + + F G CLG+ +AR E+ + +L+ N +A P PE++ Sbjct: 368 --LDLT---RPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVP--PEEV 420 Query: 469 DL 470 L Sbjct: 421 PL 422 >2IJ7-A nrPDB Length = 396 Score = 34.7 bits (78), Expect = 0.10, Method: Compositional matrix adjust. Identities = 37/192 (19%), Positives = 67/192 (34%), Gaps = 26/192 (13%) Query: 276 KSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPH 335 K A+S S + ++ F AG +T + L + +++ P + + H Sbjct: 211 KDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLL----------H 260 Query: 336 RPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTA 395 PEL A + E+ R + G+P + T ++ K V ++L A Sbjct: 261 EKPEL--------IPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGA 312 Query: 396 LHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQ 455 DP +F P + D + + F G+ C G + R + +L+ Sbjct: 313 NFDPEHFPNPGSIELDR--------PNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLK 364 Query: 456 NFSMASPVAPED 467 P D Sbjct: 365 KMPGVDLAVPID 376 >6GMF-A nrPDB Length = 397 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 51/230 (22%), Positives = 84/230 (36%), Gaps = 39/230 (16%) Query: 229 GAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLL-HMEKEKSNAHSEFSHQN 287 G Q+ ++ QE AY +E+ R +DLI L ++ EK A S N Sbjct: 173 GNAAQLERSTQEFYAYFSEVLEERRREPR----EDLISQLLAAEVDGEKLTAGEVLSFAN 228 Query: 288 LNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMP 347 +L AG ETT++ + + + +P EQ+ A + Sbjct: 229 ------TLLIAGNETTTSLIGNALVALTDHP----------EQLAAAQ--------ADLS 264 Query: 348 YTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDA 407 AV+ E+ R+ +T IP + V +L++A D F PD Sbjct: 265 LVPAVVEEVLRYESPAQCIFRQTMTD-VEIGDERIPARSVVLPLLASANRDESRFPDPDR 323 Query: 408 FNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 F+ + T+ + F L C+G +AR E + +L Sbjct: 324 FD---------IHRDTKGHLAFGLDIHFCIGAPLARLEAKVMLEVLLARL 364 >4Z5P-A nrPDB Length = 400 Score = 33.5 bits (75), Expect = 0.23, Method: Compositional matrix adjust. Identities = 51/228 (22%), Positives = 78/228 (34%), Gaps = 37/228 (16%) Query: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300 I AY+ V R +AP D LL + + + L ++L AG Sbjct: 189 IRAYLADLVSARR-----AAPHD----DLLGVLVSARDDDDRLTEDELITFGVTLLVAGH 239 Query: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360 ET++ L +L + +Q+ PEL RA + E+ RF Sbjct: 240 ETSAHQLGNMVYALLTHE----------DQLSLLREQPELLPRA--------VEELLRFV 281 Query: 361 DL-LPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGA 419 L +G I + G + V A DP F+ PD + Sbjct: 282 PLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLD---------I 332 Query: 420 LKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPED 467 ++ + F G CLG +AR EL + +L+ F P D Sbjct: 333 TREKNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPAD 380 >6F0B-A nrPDB Length = 395 Score = 33.1 bits (74), Expect = 0.31, Method: Compositional matrix adjust. Identities = 51/216 (23%), Positives = 82/216 (37%), Gaps = 43/216 (19%) Query: 233 QVYKNLQEINAYIGHSVEKHRETLDPSA-PKD-LIDTYLLHMEKEKSNAHSEFSHQNLNL 290 +V++ L E YIG V+ DPS P+D LI + +EK H+ + + Sbjct: 180 EVFRTLGE---YIGGLVQ------DPSELPEDSLIRRLVTGPYQEKQLTF----HETIGV 226 Query: 291 NTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTE 350 L L G +TT++T+ + P V+ P R P L Sbjct: 227 -ILMLIVGGYDTTASTISLSLVSYALQPEKFSVVHEH------PERIPLL---------- 269 Query: 351 AVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNP 410 + E+ R+ + +G+ I T+ G + V L A D F PD + Sbjct: 270 --VEELLRYHTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDF 327 Query: 411 DHFLDANGALKKTEAFIPFSLGKRICLGEGIARAEL 446 D + + + F G C+G+ +AR EL Sbjct: 328 D---------RPSVPHVGFGYGPHQCVGQALARVEL 354 >3B98-A nrPDB Length = 475 Score = 33.1 bits (74), Expect = 0.31, Method: Compositional matrix adjust. Identities = 72/310 (23%), Positives = 117/310 (37%), Gaps = 47/310 (15%) Query: 210 SSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSA------PKD 263 S+ Q++E F F K P R +E + EK + L PS + Sbjct: 178 SAALTQIYEEFRRFDKLLPKLARTTVN--KEEKQIASAAREKLWKWLTPSGLDRKPREQS 235 Query: 264 LIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAER 323 + +Y+ ++ E +A + L L G + G+LL +P Sbjct: 236 WLGSYVKQLQDEGIDAEMQRRAMLLQL----WVTQGNAGPAAFWVMGYLLT--HPEALRA 289 Query: 324 VYREIEQVIGPHRPPELHDRAK-MPYTEAVIYEIQRFSDLLPMGVPHIVTQH-----TSF 377 V EI+ G H L +R K P ++V++E R + + VTQ ++ Sbjct: 290 VREEIQG--GKHL--RLEERQKNTPVFDSVLWETLRLT--AAALITRDVTQDKKICLSNG 343 Query: 378 RGYIIPKDTE--VFLILSTALHDPHYFEKPDAFNPDHFLDA----------NGALKKTEA 425 + Y + + VF +S + DP ++P+ F D FL+A NGA K + Sbjct: 344 QEYHLRRGDRLCVFPFISPQM-DPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPS 402 Query: 426 FIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLT-PQECGVGKIPPT- 483 +P+ +C G A + TIL F + + L P G G + P Sbjct: 403 -VPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAG 461 Query: 484 -----YQIRF 488 Y+IRF Sbjct: 462 DLEIRYRIRF 471 Score = 28.5 bits (62), Expect = 6.2, Method: Compositional matrix adjust. Identities = 17/56 (30%), Positives = 26/56 (46%), Gaps = 1/56 (1%) Query: 37 LPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKA 92 +P LG+ L+ + K R +EK+GD+FTV + +L L D A Sbjct: 27 IPWLGHALEFGKDAA-KFLTRMKEKHGDIFTVRAAGLYITVLLDSNCYDAVLSDVA 81 >4YT3-A nrPDB Length = 410 Score = 32.7 bits (73), Expect = 0.35, Method: Compositional matrix adjust. Identities = 48/201 (23%), Positives = 76/201 (37%), Gaps = 38/201 (18%) Query: 261 PKDLIDTYLLHMEKEKSNAHSE-FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 319 P D I + LL KS E F+ + T+ + AG ETTS L F +L + Sbjct: 210 PADDIISDLL-----KSEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLL---Y 261 Query: 320 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 379 + VY+E+ + + + E+ RF L + + V + G Sbjct: 262 DDKEVYQELHE--------------NLDLVPQAVEEMLRFRFNL-IKLDRTVKEDNDLLG 306 Query: 380 YIIPKDTEVFLILSTALHDPHYFEKPDAFN---PDHFLDANGALKKTEAFIPFSLGKRIC 436 + + V + +S A D FE P N P++ + + F G C Sbjct: 307 VELKEGDSVVVWMSAANMDEEMFEDPFTLNIHRPNN-----------KKHLTFGNGPHFC 355 Query: 437 LGEGIARAELFLFFTTILQNF 457 LG +AR E + T L+ F Sbjct: 356 LGAPLARLEAKIALTAFLKKF 376 >3DBM-A nrPDB Length = 473 Score = 32.7 bits (73), Expect = 0.40, Method: Compositional matrix adjust. Identities = 23/84 (27%), Positives = 38/84 (45%), Gaps = 9/84 (10%) Query: 345 KMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR------GYIIPKDTEVFLILSTALHD 398 +MP T++V+YE R +P P ++F + + K +F A D Sbjct: 326 QMPLTKSVVYESLRIEPPVP---PQYGKAKSNFTIESHDATFEVKKGEMLFGYQPFATKD 382 Query: 399 PHYFEKPDAFNPDHFLDANGALKK 422 P F++P+ + PD F+ AL K Sbjct: 383 PKVFDRPEEYVPDRFVGDGEALLK 406 >2ZQJ-A nrPDB Length = 417 Score = 32.0 bits (71), Expect = 0.60, Method: Compositional matrix adjust. Identities = 27/96 (28%), Positives = 39/96 (40%), Gaps = 8/96 (8%) Query: 350 EAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFN 409 E + E++R+ P + +V + + K T V L L HDP ++ PD F Sbjct: 277 EMFVQEVRRYYPFGPF-LGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFR 335 Query: 410 PDHFLDANGALKKTEAFIPFSLGK----RICLGEGI 441 P+ F + L IP G C GEGI Sbjct: 336 PERFAEREENLFD---MIPQGGGHAEKGHRCPGEGI 368 >5XNT-A nrPDB Length = 411 Score = 31.6 bits (70), Expect = 0.75, Method: Compositional matrix adjust. Identities = 44/181 (24%), Positives = 69/181 (38%), Gaps = 26/181 (14%) Query: 283 FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHD 342 F+ + T+ + AG ETTS L F +L + + VY+E+ + + D Sbjct: 228 FTDDEVVRTTMLILGAGVETTSHLLANSFYSLL---YDDKEVYQELHENL---------D 275 Query: 343 RAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYF 402 E + Y RF+ + + V + G + + V + +S A D F Sbjct: 276 LVPQAVEEMLRY---RFN---LIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMF 329 Query: 403 EKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462 E DAF N + + F G CLG +AR E + TT L+ F Sbjct: 330 E--DAFT------LNIHRPNNKKHLTFGNGPHFCLGAPLARLEAKIALTTFLKKFKHIEA 381 Query: 463 V 463 V Sbjct: 382 V 382 >5M0P-A nrPDB Length = 428 Score = 31.6 bits (70), Expect = 0.80, Method: Compositional matrix adjust. Identities = 16/65 (24%), Positives = 30/65 (46%), Gaps = 1/65 (1%) Query: 355 EIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFL 414 E++R+ +P +P F+G IP + L + HD ++ P+ F P+ F Sbjct: 290 EVRRYYPFVPF-LPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFE 348 Query: 415 DANGA 419 +G+ Sbjct: 349 TWDGS 353 >2IAG-A nrPDB Length = 482 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 22/53 (41%), Positives = 29/53 (54%), Gaps = 8/53 (15%) Query: 32 PGPRPL-----PLLGNLLQMDRRGLLKSFL-RFREKYGDVFTVHLGPRPVVML 78 PG PL P LG L + SFL R +EK+GD+FT+ +G R V +L Sbjct: 5 PGEPPLDLGSIPWLGYALDFGKDA--ASFLTRMKEKHGDIFTILVGGRYVTVL 55 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 25/106 (23%), Positives = 44/106 (41%), Gaps = 16/106 (15%) Query: 398 DPHYFEKPDAFNPDHFLDANGALKK---------TEAFIPFSLGKRICLGEGIARAELFL 448 DP + P+ F + FL+ +G+ KK +P+ G CLG A + Sbjct: 372 DPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQ 431 Query: 449 FFTTILQNFSMA---SPVAPEDIDLTPQECGVGK----IPPTYQIR 487 F +L + + + V + DL+ G+ + +P Y+IR Sbjct: 432 FVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR 477 >3TKT-A nrPDB Length = 450 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 21/81 (25%), Positives = 30/81 (37%), Gaps = 9/81 (11%) Query: 375 TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434 T G I + L A HDP F +P F+P + + F G Sbjct: 347 TELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDP---------TRPANRHLAFGAGSH 397 Query: 435 ICLGEGIARAELFLFFTTILQ 455 CLG +AR E+ + +L Sbjct: 398 QCLGLHLARLEMRVLLDVLLD 418 >1Q44-A nrPDB Length = 326 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 24/77 (31%), Positives = 38/77 (49%), Gaps = 3/77 (3%) Query: 143 EERIQEEAQCLIEELRKSKGALMDPTFLFQSI--TANIICSI-VFGKRFHYQDQEFLKML 199 +E + +E + LI L K KG L+ + FQ + T I+ I + KRF +D + + + Sbjct: 13 DEDLTQETRALISSLPKEKGWLVSEIYEFQGLWHTQAILQGILICQKRFEAKDSDIILVT 72 Query: 200 NLFYQTFSLISSVFGQL 216 N T L + VF L Sbjct: 73 NPKSGTTWLKALVFALL 89 >6DCD-A nrPDB Length = 424 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 38/161 (23%), Positives = 59/161 (36%), Gaps = 27/161 (16%) Query: 295 LFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIY 354 LF AG ETT+ L ++ P + R+ RE +I P + + +M ++ + Sbjct: 249 LFAAGQETTAKLLTAAMRVLGDRPDIQRRL-RENRSLI----PNFIEESLRM---DSPVK 300 Query: 355 EIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFL 414 R + + T+ G I T V ++ A DP FE P F D Sbjct: 301 SDSR-----------LARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR-- 347 Query: 415 DANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQ 455 + F+ G C G +AR E + IL Sbjct: 348 ------PNVREHMAFARGVHSCPGGPLARVEGRVSLERILD 382 >2NZA-A nrPDB Length = 413 Score = 29.3 bits (64), Expect = 3.9, Method: Compositional matrix adjust. Identities = 22/93 (23%), Positives = 34/93 (36%), Gaps = 9/93 (9%) Query: 365 MGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTE 424 +G+ I + G I V++ A DP F PD + D D N Sbjct: 294 VGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDR--DPN------- 344 Query: 425 AFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 + + G C G +AR + L T+L+ Sbjct: 345 PHLAYGNGHHFCTGAVLARMQTELLVDTLLERL 377 >5HWK-A nrPDB Length = 240 Score = 29.3 bits (64), Expect = 4.0, Method: Compositional matrix adjust. Identities = 23/65 (35%), Positives = 32/65 (49%), Gaps = 9/65 (13%) Query: 195 FLKMLNLFYQTFSLISSVFGQLFELFS-GFLKYFPGAHRQV---YKNLQEINAYIGHSVE 250 FLK +NL+ + S+ +L + G + Y P H Q Y N++E N Y H VE Sbjct: 71 FLKNVNLYSE-----SAPIQDPDDLVTIGVVYYIPPEHAQEVREYLNVREQNGYTLHEVE 125 Query: 251 KHRET 255 H ET Sbjct: 126 VHLET 130 >3TML-A nrPDB Length = 288 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 24/43 (55%), Gaps = 2/43 (4%) Query: 5 VLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPL--LGNLLQ 45 VL A+ TG+ L ++ HPN + GP +PL +G LL+ Sbjct: 226 VLARAAVATGVAGLFMETHPNPAEAKSDGPNAVPLNRMGALLE 268 >3LXD-A nrPDB Length = 415 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 15/43 (34%), Positives = 23/43 (53%), Gaps = 2/43 (4%) Query: 105 DPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQ 147 DP R + V++ G KV+ V ++D+ GK+ VE R Q Sbjct: 357 DPATRSFSVVYLKGG--KVVALDCVNMVKDYVQGKKLVEARAQ 397 >2RCM-A nrPDB Length = 495 Score = 28.5 bits (62), Expect = 6.4, Method: Compositional matrix adjust. Identities = 38/144 (26%), Positives = 58/144 (40%), Gaps = 25/144 (17%) Query: 292 TLSLFFAGTETTSTTLRYGFLLMLKY-----PHVAERVYREIEQVIGPHRPPELHDRA-- 344 T +L FA T ++ F M+K V R+ EI VI + EL A Sbjct: 284 THNLLFATCFNTWGGMKILFPNMVKRIGRAGHQVHNRLAEEIRSVIKSNGG-ELTMGAIE 342 Query: 345 KMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT-SFRGYIIPKDTEVFLILST--------- 394 KM T++V+YE RF P + Q+ + + +I F + + Sbjct: 343 KMELTKSVVYECLRFE-------PPVTAQYGRAKKDLVIESHDAAFKVKAGEMLYGYQPL 395 Query: 395 ALHDPHYFEKPDAFNPDHFLDANG 418 A DP F++ D F P+ F+ G Sbjct: 396 ATRDPKIFDRADEFVPERFVGEEG 419 >3BUJ-A nrPDB Length = 397 Score = 28.1 bits (61), Expect = 8.1, Method: Compositional matrix adjust. Identities = 15/58 (25%), Positives = 26/58 (44%), Gaps = 9/58 (15%) Query: 388 VFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAE 445 V ++ A DP +++PD F+ + + + F G R CLG +AR + Sbjct: 304 VVVLAGAANRDPRRYDRPDDFDIE---------RDPVPSMSFGAGMRYCLGSYLARTQ 352 >5JGL-A nrPDB Length = 289 Score = 28.1 bits (61), Expect = 8.5, Method: Compositional matrix adjust. Identities = 32/108 (29%), Positives = 43/108 (39%), Gaps = 22/108 (20%) Query: 382 IPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGI 441 + +T++ L T L D HY AF F DAN ALK E F RI GI Sbjct: 103 VNAETKIVNALDTGLPDGHYTHVFVAFGFQSFPDANAALK--ECF-------RILASGGI 153 Query: 442 ARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFL 489 ++ QNF+ P+ I+ P G +P Q F+ Sbjct: 154 -------LASSTWQNFNWI-PIMKAAIETIP-----GNLPFPTQKEFI 188 >3MCR-A nrPDB Length = 213 Score = 28.1 bits (61), Expect = 9.7, Method: Compositional matrix adjust. Identities = 17/54 (31%), Positives = 25/54 (46%), Gaps = 1/54 (1%) Query: 275 EKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKY-PHVAERVYRE 327 EK N E Q +N + G +TT T YG L + ++ P A+R Y + Sbjct: 15 EKDNLPRELGTQRINSPIARMGMFGAKTTGDTSGYGRLRVYRHVPAAAQRPYSD 68 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3IBD-A nrPDB 594 e-170 4H1N-A nrPDB 580 e-166 2NNH-A nrPDB 566 e-162 5W0C-A nrPDB 559 e-160 4GQS-A nrPDB 557 e-159 5E0E-A nrPDB 555 e-158 5E58-A nrPDB 552 e-157 1N6B-A nrPDB 550 e-157 3E6I-A nrPDB 531 e-151 2PG7-A nrPDB 529 e-150 6B82-A nrPDB 427 e-120 6DWN-A nrPDB 404 e-113 4R20-A nrPDB 403 e-113 3DL9-A nrPDB 399 e-111 3TBG-A nrPDB 396 e-111 5UYS-A nrPDB 388 e-108 4R1Z-A nrPDB 381 e-106 2HI4-A nrPDB 380 e-106 5VBU-A nrPDB 362 e-100 6IQ5-A nrPDB 360 e-99 3QZ1-A nrPDB 356 2e-98 6DA2-A nrPDB 335 4e-92 5VEU-A nrPDB 330 8e-91 5YLW-A nrPDB 326 1e-89 6AYB-A nrPDB 322 3e-88 2WX2-A nrPDB 313 1e-85 5JLC-A nrPDB 309 2e-84 4WMZ-A nrPDB 303 9e-83 3L4D-A nrPDB 300 8e-82 6C94-A nrPDB 295 2e-80 3JUS-A nrPDB 291 4e-79 5FSA-A nrPDB 286 1e-77 3K9V-A nrPDB 285 4e-77 3EL3-A nrPDB 268 3e-72 2W0A-A nrPDB 267 8e-72 2VE3-A nrPDB 259 2e-69 6CR2-A nrPDB 255 4e-68 3MDV-A nrPDB 252 3e-67 4KPA-A nrPDB 247 7e-66 2VZM-A nrPDB 208 5e-54 5CJE-A nrPDB 207 1e-53 4OQS-A nrPDB 200 1e-51 3N9Z-A nrPDB 199 3e-51 4OQR-A nrPDB 197 8e-51 2Z36-A nrPDB 197 9e-51 4UBS-A nrPDB 196 1e-50 3MZS-A nrPDB 194 6e-50 4YZR-A nrPDB 194 8e-50 5EX6-C nrPDB 194 9e-50 2ZBZ-A nrPDB 191 8e-49 2Y5N-A nrPDB 190 1e-48 3SN5-A nrPDB 188 4e-48 3EJB-B nrPDB 188 6e-48 3MGX-A nrPDB 186 2e-47 5Y1I-A nrPDB 184 1e-46 4GGV-A nrPDB 184 1e-46 3S79-A nrPDB 182 2e-46 4ZGX-A nrPDB 181 6e-46 5IT1-A nrPDB 181 8e-46 6M7X-A nrPDB 179 2e-45 4WPZ-A nrPDB 179 2e-45 3ABA-A nrPDB 177 1e-44 2WM5-A nrPDB 177 1e-44 6GK6-A nrPDB 175 4e-44 3ABB-A nrPDB 175 4e-44 5FOI-A nrPDB 175 4e-44 5LIE-A nrPDB 175 5e-44 6B11-A nrPDB 174 5e-44 1LG9-A nrPDB 174 8e-44 6M7L-A nrPDB 173 1e-43 5NWS-A nrPDB 172 4e-43 3NC3-A nrPDB 169 3e-42 3TYW-A nrPDB 168 6e-42 5Z9I-A nrPDB 163 2e-40 4TRI-A nrPDB 162 2e-40 6G5O-A nrPDB 159 2e-39 3P3Z-A nrPDB 157 8e-39 2XKR-A nrPDB 155 5e-38 3A1L-A nrPDB 151 7e-37 1Q5D-A nrPDB 146 2e-35 5FYF-A nrPDB 145 5e-35 5HDI-A nrPDB 144 1e-34 1WIY-A nrPDB 141 9e-34 4DO1-A nrPDB 139 2e-33 6FYJ-A nrPDB 124 8e-29 6G71-A nrPDB 121 8e-28 5YHJ-A nrPDB 117 1e-26 Sequences not found previously or not previously below threshold: 2X2N-A nrPDB 282 3e-76 5L94-A nrPDB 193 2e-49 5VWS-A nrPDB 188 7e-48 1Z8P-A nrPDB 180 1e-45 3A50-A nrPDB 178 4e-45 4RM4-A nrPDB 177 9e-45 5OFQ-A nrPDB 173 1e-43 4Z5P-A nrPDB 173 1e-43 6FSH-A nrPDB 171 9e-43 3WVS-A nrPDB 169 2e-42 6F0B-A nrPDB 169 2e-42 5YSW-A nrPDB 169 2e-42 1EHE-A nrPDB 169 3e-42 4TX3-A nrPDB 168 5e-42 4JBT-A nrPDB 168 5e-42 1CPT-A nrPDB 166 2e-41 4MM0-A nrPDB 166 3e-41 6CVC-A nrPDB 164 5e-41 3R9C-A nrPDB 164 9e-41 1UED-A nrPDB 163 2e-40 5XW2-A nrPDB 162 3e-40 6GMF-A nrPDB 159 2e-39 1ODO-A nrPDB 159 4e-39 6A7J-A nrPDB 158 5e-39 4Z5Q-A nrPDB 156 2e-38 5XJN-A nrPDB 156 2e-38 5GWE-A nrPDB 156 2e-38 1GWI-A nrPDB 154 1e-37 6A7I-A nrPDB 153 1e-37 6HQG-A nrPDB 152 3e-37 5XNT-A nrPDB 151 5e-37 4XE3-A nrPDB 150 1e-36 2WIO-A nrPDB 149 2e-36 4YT3-A nrPDB 149 2e-36 5L1U-A nrPDB 147 7e-36 3RWL-A nrPDB 147 7e-36 3TKT-A nrPDB 145 4e-35 5DE9-A nrPDB 144 1e-34 6HQW-A nrPDB 142 2e-34 5DQN-A nrPDB 142 3e-34 2FR7-A nrPDB 141 5e-34 1F4U-A nrPDB 137 8e-33 2RFC-A nrPDB 137 1e-32 1UE8-A nrPDB 137 1e-32 3IVY-A nrPDB 136 2e-32 4PWV-A nrPDB 136 3e-32 5HH3-A nrPDB 136 3e-32 3OO3-A nrPDB 132 4e-31 5LIV-A nrPDB 131 6e-31 6F88-A nrPDB 130 9e-31 6GII-A nrPDB 130 1e-30 2X9P-A nrPDB 130 2e-30 5HIW-A nrPDB 129 2e-30 5H1Z-A nrPDB 129 4e-30 6HQD-A nrPDB 128 6e-30 6DCD-A nrPDB 125 4e-29 2NZA-A nrPDB 125 5e-29 2UUQ-A nrPDB 124 1e-28 5EX8-A nrPDB 122 3e-28 3OFT-A nrPDB 120 2e-27 3WEC-A nrPDB 119 2e-27 6BLD-A nrPDB 118 4e-27 5D3U-A nrPDB 115 3e-26 3B98-A nrPDB 115 3e-26 4FB2-A nrPDB 112 3e-25 2WIY-A nrPDB 112 4e-25 2IJ7-A nrPDB 111 8e-25 2IAG-A nrPDB 110 9e-25 2QBO-A nrPDB 110 2e-24 2ZQJ-A nrPDB 109 2e-24 5OMS-A nrPDB 107 1e-23 5M0P-A nrPDB 106 2e-23 5KYO-A nrPDB 106 3e-23 3BUJ-A nrPDB 105 6e-23 3AWQ-A nrPDB 99 3e-21 3NV6-A nrPDB 92 4e-19 4C9K-A nrPDB 84 1e-16 2RCM-A nrPDB 82 7e-16 3DBM-A nrPDB 73 3e-13 2YJN-B nrPDB 60 2e-09 5V0C-Z nrPDB 31 1.1 4YXC-B nrPDB 31 1.3 4YXB-D nrPDB 30 1.7 3A4L-A nrPDB 30 2.2 5L9W-B nrPDB 30 3.1 4B2T-H nrPDB 29 3.7 3RFT-A nrPDB 29 4.4 2KC5-A nrPDB 29 7.0 4R1I-A nrPDB 28 9.9 >3IBD-A nrPDB Length = 476 Score = 594 bits (1531), Expect = e-170, Method: Composition-based stats. Identities = 460/472 (97%), Positives = 467/472 (98%) Query: 20 VQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 79 + + ++ +LPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC Sbjct: 1 MAKKTSSKGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 60 Query: 80 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK 139 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK Sbjct: 61 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK 120 Query: 140 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML Sbjct: 121 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 180 Query: 200 NLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 259 NLFYQTFSLISSVFGQLFELFSGFLK+FPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS Sbjct: 181 NLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 240 Query: 260 APKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 319 AP+DLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH Sbjct: 241 APRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 300 Query: 320 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 379 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG Sbjct: 301 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 360 Query: 380 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 439 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE Sbjct: 361 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 420 Query: 440 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR Sbjct: 421 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 472 >4H1N-A nrPDB Length = 479 Score = 580 bits (1494), Expect = e-166, Method: Composition-based stats. Identities = 363/472 (76%), Positives = 412/472 (87%) Query: 20 VQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 79 + + ++ +LPPGP PLP+LGNLLQMDR+GLL+SFLR REKYGDVFTV+LG RPVV+LC Sbjct: 1 MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC 60 Query: 80 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK 139 G +AIREALVD+AEAFSGRGKIA+VDP F+GYGVIFANG RW+ LRRFS+ TMRDFGMGK Sbjct: 61 GTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGMGK 120 Query: 140 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199 RSVEERIQEEA+CL+EELRKSKGAL+D T LF SIT+NIICSIVFGKRF Y+D FL++L Sbjct: 121 RSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLL 180 Query: 200 NLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 259 +LF+Q+FSLISS Q+FELFSGFLKYFPG HRQ+Y+NLQEIN +IG SVEKHR TLDPS Sbjct: 181 DLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPS 240 Query: 260 APKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 319 P+D ID YLL MEK+KS+ SEF HQNL L LSLF AGTETTSTTLRYGFLLMLKYPH Sbjct: 241 NPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPH 300 Query: 320 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 379 V ERV +EIEQVIG HRPP L DRAKMPYT+AVI+EIQR DL+P GVPH VT+ T FRG Sbjct: 301 VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRG 360 Query: 380 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 439 Y+IPK+TEVF +LS+ALHDP YFE P+ FNP HFLDANGALK+ E F+PFSLGKRICLGE Sbjct: 361 YVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGE 420 Query: 440 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 GIAR ELFLFFTTILQNFS+ASPV PEDIDLTP+E GVG +PP+YQIRFL R Sbjct: 421 GIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFLAR 472 >2NNH-A nrPDB Length = 476 Score = 566 bits (1458), Expect = e-162, Method: Composition-based stats. Identities = 238/471 (50%), Positives = 329/471 (69%) Query: 20 VQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 79 + + ++ +LPPGP PLP++GN+LQ+D + + KSF F + YG VFTV+ G P+V+ Sbjct: 1 MAKKTSSKGKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFH 60 Query: 80 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK 139 G EA++EAL+D E FSGRG + +G G+I +NG RWK +RRFS+TT+R+FGMGK Sbjct: 61 GYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGK 120 Query: 140 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199 RS+E+R+QEEA CL+EELRK+K + DPTF+ N+ICS+VF KRF Y+DQ FL ++ Sbjct: 121 RSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLM 180 Query: 200 NLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 259 F + F +++S + Q+ F + FPG H +V KN+ +YI V++H+ +LD + Sbjct: 181 KRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVN 240 Query: 260 APKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 319 P+D ID +L+ ME+EK N SEF+ +NL LF AGTETTSTTLRYG LL+LK+P Sbjct: 241 NPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPE 300 Query: 320 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 379 V +V EI+ VIG HR P + DR+ MPYT+AV++EIQR+SDL+P GVPH VT T FR Sbjct: 301 VTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRN 360 Query: 380 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 439 Y+IPK T + +L++ LHD F P+ F+P HFLD NG KK++ F+PFS GKRIC GE Sbjct: 361 YLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGE 420 Query: 440 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLP 490 G+AR ELFLF TTILQNF++ S ++++ T G+ +PP+YQI F+P Sbjct: 421 GLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIP 471 >5W0C-A nrPDB Length = 477 Score = 559 bits (1441), Expect = e-160, Method: Composition-based stats. Identities = 228/472 (48%), Positives = 331/472 (70%) Query: 19 LVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVML 78 + ++ + +LPPGP PLP++GN+LQ+ + + KS + YG VFT++ G +P+V+L Sbjct: 1 MAKKTSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL 60 Query: 79 CGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMG 138 G EA++EAL+D E FSGRG + + RG+G++F+NG +WK +RRFS+ T+R+FGMG Sbjct: 61 HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 120 Query: 139 KRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKM 198 KRS+E+R+QEEA+CL+EELRK+K + DPTF+ N+ICSI+F KRF Y+DQ+FL + Sbjct: 121 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNL 180 Query: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDP 258 + + ++SS + Q+ FS + YFPG H ++ KN+ + +YI V++H+E++D Sbjct: 181 MEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDM 240 Query: 259 SAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP 318 + P+D ID +L+ MEKEK N SEF+ ++L + LF AGTETTSTTLRY LL+LK+P Sbjct: 241 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 300 Query: 319 HVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378 V +V EIE+VIG +R P + DR+ MPYT+AV++E+QR+ DLLP +PH VT FR Sbjct: 301 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 360 Query: 379 GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLG 438 Y+IPK T + + L++ LHD F P+ F+P HFLD G KK++ F+PFS GKRIC+G Sbjct: 361 NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVG 420 Query: 439 EGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLP 490 E +A ELFLF T+ILQNF++ S V P+++D TP G +PP YQ+ F+P Sbjct: 421 EALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP 472 >4GQS-A nrPDB Length = 477 Score = 557 bits (1435), Expect = e-159, Method: Composition-based stats. Identities = 226/472 (47%), Positives = 324/472 (68%) Query: 19 LVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVML 78 + ++ + +LPPGP PLP++GN+LQ+D + + KS + YG VFT++ G +V+L Sbjct: 1 MAKKTSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL 60 Query: 79 CGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMG 138 G E ++EAL+D E FSGRG + + RG+G++F+NG RWK +RRFS+ T+R+FGMG Sbjct: 61 HGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMG 120 Query: 139 KRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKM 198 KRS+E+R+QEEA+CL+EELRK+K + DPTF+ N+ICSI+F KRF Y+DQ+FL + Sbjct: 121 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNL 180 Query: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDP 258 + + ++S+ + Q+ F + YFPG H ++ KNL + + I V++H+E++D Sbjct: 181 MEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDI 240 Query: 259 SAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP 318 + P+D ID +L+ MEKEK N SEF+ +NL + L AGTETTSTTLRY LL+LK+P Sbjct: 241 NNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP 300 Query: 319 HVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378 V +V EIE+V+G +R P + DR MPYT+AV++E+QR+ DL+P +PH VT FR Sbjct: 301 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFR 360 Query: 379 GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLG 438 Y+IPK T + L++ LHD F P+ F+P HFLD G KK+ F+PFS GKRIC+G Sbjct: 361 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 420 Query: 439 EGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLP 490 EG+AR ELFLF T ILQNF++ S + P+D+D TP G +PP YQ+ F+P Sbjct: 421 EGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 472 >5E0E-A nrPDB Length = 463 Score = 555 bits (1430), Expect = e-158, Method: Composition-based stats. Identities = 354/450 (78%), Positives = 398/450 (88%) Query: 42 NLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKI 101 NLLQMDR G L SF R REKYGDVFTVHLGPRPVVML G EAIREALVD+AEAFSGRG I Sbjct: 14 NLLQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 73 Query: 102 AMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSK 161 A+V+P FRGYGV+FANG RWK LRRFS+ TMRDFGMGKRSVEERIQEEA+CL+EE RKS+ Sbjct: 74 AVVEPIFRGYGVVFANGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQ 133 Query: 162 GALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFS 221 GA +DPTFLFQ ITANIICSIVFG+RF Y+D +FL++L LFYQ+FSLISS Q+FELFS Sbjct: 134 GAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFS 193 Query: 222 GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHS 281 GFLKYFPG HRQ+ +NLQEI YIG SVEKHR TLDPS P+D IDTYLL MEKEKSN H+ Sbjct: 194 GFLKYFPGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHT 253 Query: 282 EFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELH 341 EF HQNL ++ LSLFFAGTET+STTLRYGFLLMLKYPHVAE+V +EI+QVIG HR P L Sbjct: 254 EFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 313 Query: 342 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 401 DR KMPYTEAVIYEIQRFSDL+P+GVPH VT+ T FRGY++PK+TEV+ ILS+ALHDP Y Sbjct: 314 DRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 373 Query: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 461 FE+PD FNPDHFLDANGALKK+EAF+PFS+GKRICLGEGIAR ELFLFFTTILQNFS++S Sbjct: 374 FEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLSS 433 Query: 462 PVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 PVAP+DIDL+P+E G GK+P TYQI FL R Sbjct: 434 PVAPKDIDLSPKESGFGKVPQTYQICFLAR 463 >5E58-A nrPDB Length = 493 Score = 552 bits (1421), Expect = e-157, Method: Composition-based stats. Identities = 343/450 (76%), Positives = 397/450 (88%) Query: 42 NLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKI 101 NLLQMDR G L SF+R REKYGDVFTVHLGPRPVVML G EAIREALVD+AEAFSGRG I Sbjct: 42 NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 101 Query: 102 AMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSK 161 A++ P YG+IF+NG RWKVLRRFS+ TMRDFGMGKRSVE+RIQEEAQCL+EEL+KS+ Sbjct: 102 AVIKPVIGDYGMIFSNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQ 161 Query: 162 GALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFS 221 GA +DPTFLFQ ITANIICSIVFG+R+ Y+D++FL++L+LFY+TFSL+SS Q+FELFS Sbjct: 162 GAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFS 221 Query: 222 GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHS 281 GF+KYFPGAHRQ+ +NLQEI Y+G SVEKHR TLDPS P+D IDTYLL MEKEKSN H+ Sbjct: 222 GFMKYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHT 281 Query: 282 EFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELH 341 EF HQNL ++ LSLFFAGTETTSTTLRYGFLLMLKYPHVAE+V +EI+QVIG HR P L Sbjct: 282 EFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 341 Query: 342 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 401 DR KMPYT+AVI+EIQRFSDL P+G PH VT+ T FRGY++PK+TEV+ ILS+ALHDP Y Sbjct: 342 DRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 401 Query: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 461 FE+P FNPDHFLDANGALKK+EAF+PFS+GKRICLGEGIAR ELFLFFTTILQNFS++S Sbjct: 402 FEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSS 461 Query: 462 PVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 VAP+DIDL+P+E G+GK+P TYQI FL R Sbjct: 462 SVAPKDIDLSPKESGIGKVPQTYQISFLAR 491 >1N6B-A nrPDB Length = 473 Score = 550 bits (1417), Expect = e-157, Method: Composition-based stats. Identities = 231/471 (49%), Positives = 329/471 (69%), Gaps = 3/471 (0%) Query: 20 VQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 79 + + ++ +LPPGP P P++GN+LQ+D + + KS +F E YG VFTV+LG +P V+L Sbjct: 1 MAKKTSSKGKLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLH 60 Query: 80 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK 139 G EA++EALVD E F+GRG + +++ +G G+ F+N WK +RRFS+ T+R+FGMGK Sbjct: 61 GYEAVKEALVDLGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGK 120 Query: 140 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199 RS+E+RIQEEA+CL+EELRK+ + DPTF+ N+ICS++F RF Y+D+EFLK++ Sbjct: 121 RSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLM 180 Query: 200 NLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 259 ++ L+ + + Q++ F L YFPG H+ + KN I +I V++H++ LD + Sbjct: 181 ESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVN 240 Query: 260 APKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 319 P+D ID +L+ ME+E + EF+ ++L + LF AGTETTSTTLRY LL+LK+P Sbjct: 241 NPRDFIDCFLIKMEQEN---NLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPE 297 Query: 320 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 379 VA RV EIE+VIG HR P + DR++MPYT+AVI+EIQRF DLLP +PH VT+ FR Sbjct: 298 VAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRN 357 Query: 380 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 439 Y IPK T++ L++ LHD F P F+P HFLD +G KK++ F+PFS GKR+C+GE Sbjct: 358 YFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGE 417 Query: 440 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLP 490 G+AR ELFLF T+ILQNF + S V P+D+D+T G +PP+YQ+ F+P Sbjct: 418 GLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFIP 468 >3E6I-A nrPDB Length = 476 Score = 531 bits (1368), Expect = e-151, Method: Composition-based stats. Identities = 220/472 (46%), Positives = 321/472 (68%), Gaps = 1/472 (0%) Query: 20 VQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 79 + + ++ +LPPGP PLP++GNL Q++ + + KSF R +++G VFT+++G + +V++ Sbjct: 1 MAKKTSSKGKLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 60 Query: 80 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK 139 G +A++EAL+D + FSGRG + R G+IF NG WK +RRFS+TT+R++GMGK Sbjct: 61 GYKAVKEALLDYKDEFSGRGDLPAFHAH-RDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK 119 Query: 140 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199 + E RIQ EA L+E LRK++G DPTFL N+I I+F K F Y D++FL+++ Sbjct: 120 QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 179 Query: 200 NLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 259 LF + F L+S+ + QL+ F FL Y PG+HR+V KN+ E+ Y+ V++H ++LDP+ Sbjct: 180 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 239 Query: 260 APKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 319 P+DL D L+ MEKEK +A ++ + + LFFAGTETTSTTLRYG L+++KYP Sbjct: 240 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 299 Query: 320 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 379 + E+++ EI++VIGP R P + DR +MPY +AV++EIQRF L+P +PH T+ T FRG Sbjct: 300 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 359 Query: 380 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 439 Y+IPK T V L + L+D F P+ F P+HFL+ NG K ++ F PFS GKR+C GE Sbjct: 360 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 419 Query: 440 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 G+AR ELFL ILQ+F++ V P+DIDL+P G G IPP Y++ +PR Sbjct: 420 GLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 471 >2PG7-A nrPDB Length = 476 Score = 529 bits (1363), Expect = e-150, Method: Composition-based stats. Identities = 245/472 (51%), Positives = 339/472 (71%) Query: 20 VQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 79 + + ++ +LPPGP PLP +GN LQ++ + S ++ E+YG VFT+HLGPR VV+LC Sbjct: 1 MAKKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC 60 Query: 80 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK 139 G +A+REALVD+AE FSGRG+ A D F+GYGV+F+NG R K LRRFS+ T+RDFG+GK Sbjct: 61 GHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGK 120 Query: 140 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199 R +EERIQEEA LI+ LR + GA +DPTF +N+I SIVFG RF Y+D+EFL +L Sbjct: 121 RGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLL 180 Query: 200 NLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 259 + F S+ GQL+E+FS +K+ PG +Q ++ LQ + +I VE ++ TLDP+ Sbjct: 181 RMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPN 240 Query: 260 APKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 319 +P+D ID++L+ M++E+ N ++EF +NL + TL LF GTET STTLRYGFLL++K+P Sbjct: 241 SPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPE 300 Query: 320 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 379 V +V+ EI++VIG +R P+ DRAKMPY EAVI+EIQRF D++PM + V + T FR Sbjct: 301 VEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 360 Query: 380 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 439 + +PK TEV+ +L + L DP +F P FNP HFL+ G KK++AF+PFS+GKR C GE Sbjct: 361 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGE 420 Query: 440 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 G+AR ELFLFFTT++QNF + S +P+DID++P+ G IP Y + FLPR Sbjct: 421 GLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 472 >6B82-A nrPDB Length = 509 Score = 427 bits (1098), Expect = e-120, Method: Composition-based stats. Identities = 129/490 (26%), Positives = 234/490 (47%), Gaps = 27/490 (5%) Query: 20 VQRHPNTHDR-------------LPPGPRPLPLLGNLLQMDRRGLLK-SFLRFREKYGDV 65 + + ++ + PP LP++G+L+ + F ++KYGD+ Sbjct: 1 MAKKTSSKGKKQKMNGFVPAGNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDL 60 Query: 66 FTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFR-GYGVIFAN-GNRWKV 123 +++ +G ++++ +E L+ K + F+GR + D R G + FA+ + WK Sbjct: 61 YSLMMGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKF 120 Query: 124 LRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIV 183 R+ + FG G S+E+ I EA + E L +S+ + +D N++C++ Sbjct: 121 HRKMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALC 180 Query: 184 FGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINA 243 F + D EF ML Y + + L ++F +L+ FP ++ + I Sbjct: 181 FNSSYKRGDAEFESMLQ--YSQGIVDTVAKDSLVDIFP-WLQIFPNKDLRILRQCISIRD 237 Query: 244 -YIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSE----FSHQNLNLNTLSLFFA 298 + E+H+ T + +DL+D L ++N S + ++ + +F A Sbjct: 238 KLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGA 297 Query: 299 GTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQR 358 G ETT+TTL++ ++ P V ++ E++ IG R P+L DR +PY EA I E+ R Sbjct: 298 GVETTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMR 357 Query: 359 FSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDA-- 416 + P+ +PH+ Q +S Y + K T V + + + HD ++ P+ F+P FL+ Sbjct: 358 IRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEG 417 Query: 417 NGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECG 476 +G + +++PF G R+CLGE +A+ ELFLF ILQ F++ P DL + G Sbjct: 418 DGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDL-QGKFG 476 Query: 477 VGKIPPTYQI 486 V P +++ Sbjct: 477 VVLQPKKFKV 486 >6DWN-A nrPDB Length = 491 Score = 404 bits (1039), Expect = e-113, Method: Composition-based stats. Identities = 139/470 (29%), Positives = 243/470 (51%), Gaps = 22/470 (4%) Query: 20 VQRHPNTHD-RLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVML 78 + + ++ + PPGP PL+G++L + + L + R ++YGDV + +G PVV+L Sbjct: 1 MAKKTSSKGLKNPPGPWGWPLIGHMLTLGKNPHL-ALSRMSQQYGDVLQIRIGSTPVVVL 59 Query: 79 CGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIF--ANGNRWKVLRRFSVTTMRDFG 136 G++ IR+ALV + + F GR + G + F +G W RR + ++ F Sbjct: 60 SGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFS 119 Query: 137 MGKR-------SVEERIQEEAQCLIEELRKSKGAL--MDPTFLFQSITANIICSIVFGKR 187 + +EE + +EA+ LI L++ +P N+IC+I FG+R Sbjct: 120 IASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRR 179 Query: 188 FHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL-QEINAYIG 246 + + QE L ++NL ++ S G + L+Y P +K+L ++ +++ Sbjct: 180 YDHNHQELLSLVNLNNNFGEVVGS--GNPADFIP-ILRYLPNPSLNAFKDLNEKFYSFMQ 236 Query: 247 HSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHS--EFSHQNLNLNTLSLFFAGTETTS 304 V++H +T + +D+ D+ + H ++++ + ++ + S + + L LF AG +T + Sbjct: 237 KMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVT 296 Query: 305 TTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLP 364 T + + + ++ P V ++ E++ VIG R P L DR+ +PY EA I E R S +P Sbjct: 297 TAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVP 356 Query: 365 MGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK-- 422 +PH T+ TS +G+ IPK VF+ HD + P F P+ FL +GA+ K Sbjct: 357 FTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVL 416 Query: 423 TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTP 472 +E I F +GKR C+GE IAR E+FLF +LQ + P+ + +D+TP Sbjct: 417 SEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTP 465 >4R20-A nrPDB Length = 486 Score = 403 bits (1036), Expect = e-113, Method: Composition-based stats. Identities = 140/484 (28%), Positives = 235/484 (48%), Gaps = 17/484 (3%) Query: 20 VQRHPNTHDRLPPGP--RPLPLLGNLLQMDRR-------GLLKSFLRFREKYGDVFTVHL 70 + + ++ + G P L L + F + +YG +F ++ Sbjct: 1 MAKKTSSKGKEGVGSSSVSFPCLPRLPLLGSLLHLRSNLPPHLLFTQLSSQYGPLFGLYA 60 Query: 71 GPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFF-RGYGVIFAN-GNRWKVLRRFS 128 GP +++ + +RE L+ + F+GR K+ D G + FA+ WK RR Sbjct: 61 GPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQGGKDIAFADYSPLWKNHRRLV 120 Query: 129 VTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRF 188 ++ FG G ++ +QE A L EEL+ +G D + + N+IC +VF + Sbjct: 121 HSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSVVLMRAVTNVICRLVFSSSY 180 Query: 189 HYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINA-YIGH 247 D E ++ I+ G L ++F +L+ FP + K I + Sbjct: 181 QPSDPELQTVIQYNDGIVQTIAR--GGLVDIFP-WLRIFPNKDLKRLKECVSIRDQLLYK 237 Query: 248 SVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTL 307 + +H+++L P P+DL+D L+ ++ A + + ++ + F AG ETTSTTL Sbjct: 238 KLLEHKKSLTPGEPRDLLDALLIGQQRGSGGAD-DITEDHVLMTAAEAFGAGVETTSTTL 296 Query: 308 RYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGV 367 + +L +P + ERV E+++ +G RPP L DR +P +AV+ E+ R + P+ + Sbjct: 297 LWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDAVLCEVMRIRPVSPILI 356 Query: 368 PHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFI 427 PH+ Q TS G+ +PK T V + + HDP ++++P+ FNP+ FL+ +G K +F+ Sbjct: 357 PHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPERFLEPSGKKKTQSSFL 416 Query: 428 PFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIR 487 PF G R+C+GE +AR ELFLF + LQ FS + P DL + GV P Y + Sbjct: 417 PFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPSEASLPDLQGR-FGVVLQPERYTVT 475 Query: 488 FLPR 491 PR Sbjct: 476 VTPR 479 >3DL9-A nrPDB Length = 479 Score = 399 bits (1024), Expect = e-111, Method: Composition-based stats. Identities = 154/440 (35%), Positives = 245/440 (55%), Gaps = 5/440 (1%) Query: 54 SFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGV 113 + + YG++F++ LG V+L G + ++E LV ++E F+ R + + + G+ Sbjct: 39 YMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGL 98 Query: 114 IFAN-GNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQ 172 + + G W RR +V + R FG G++S E +I EE + + + KG D L Sbjct: 99 LNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLIT 158 Query: 173 SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFP-GAH 231 + +NI I+FG+RF Y+D +F M+ LF + L +S L+ F ++ P G H Sbjct: 159 NAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP-WIGILPFGKH 217 Query: 232 RQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLN 291 +Q+++N + ++ +EK P P+ +D YL M++ K++ S FS +NL + Sbjct: 218 QQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFS 277 Query: 292 TLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEA 351 L AGTETT+ LR+ L M YP++ +V +EI+ ++GP+ P D+ KMPYTEA Sbjct: 278 VGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEA 337 Query: 352 VIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPD 411 V++E+ RF +++P+G+ H ++ RGY IPK T V L + D Y+ P+ F+P+ Sbjct: 338 VLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPE 397 Query: 412 HFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLT 471 FLD++G K EA +PFSLG+R CLGE +AR E+FLFFT +LQ F + P DL Sbjct: 398 RFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELV-PDLK 456 Query: 472 PQECGVGKIPPTYQIRFLPR 491 P+ G+ P Y I R Sbjct: 457 PR-LGMTLQPQPYLICAERR 475 >3TBG-A nrPDB Length = 479 Score = 396 bits (1018), Expect = e-111, Method: Composition-based stats. Identities = 189/477 (39%), Positives = 272/477 (57%), Gaps = 7/477 (1%) Query: 20 VQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 79 + + ++ +LPPGP PLP LGNLL +D + F + R ++GDVF++ L PVV+L Sbjct: 1 MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN 60 Query: 80 GVEAIREALVDKAEAFSGRGKIAMVDPFFRG---YGVIFAN-GNRWKVLRRFSVTTMRDF 135 G+ A+REALV E + R + + G GV A G W+ RRFSV+T+R+ Sbjct: 61 GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL 120 Query: 136 GMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEF 195 G+GK+S+E+ + EEA CL G P L +N+I S+ G+RF Y D F Sbjct: 121 GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF 180 Query: 196 LKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRET 255 L++L+L + S ++ L + P +V + + + + +HR T Sbjct: 181 LRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRFQKAFLTQLDELLTEHRMT 239 Query: 256 LDPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM 314 DP+ P +DL + +L MEK K N S F+ +NL + LF AG TTSTTL +G LLM Sbjct: 240 WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM 299 Query: 315 LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH 374 + +P V RV +EI+ VIG R PE+ D+A MPYT AVI+E+QRF D++P+GV H+ ++ Sbjct: 300 ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRD 359 Query: 375 TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434 +G+ IPK T + LS+ L D +EKP F+P+HFLDA G K EAF+PFS G+R Sbjct: 360 IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR 419 Query: 435 ICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 CLGE +AR ELFLFFT++LQ+FS + P P Y++ +PR Sbjct: 420 ACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHG-VFAFLVSPSPYELCAVPR 475 >5UYS-A nrPDB Length = 494 Score = 388 bits (996), Expect = e-108, Method: Composition-based stats. Identities = 127/470 (27%), Positives = 224/470 (47%), Gaps = 17/470 (3%) Query: 20 VQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLL-KSFLRFREKYGDVFTVHLGPRPVVML 78 + + + P LPL+G+L + R G + +F + ++KYG +++V +G + V++ Sbjct: 1 MAKKT--GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIV 58 Query: 79 CGVEAIREALVDKAEAFSGRGKIAMVDPFFRG-YGVIFAN-GNRWKVLRRFSVTTMRDFG 136 + +E L+ K + FSGR ++A +D G+ FA+ G W++ RR ++ T F Sbjct: 59 GHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFK 118 Query: 137 MGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL 196 G + +E+ I +E L + L G +D +F N+I I F + D E Sbjct: 119 DGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELN 178 Query: 197 KMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEI-NAYIGHSVEKHRET 255 + N +S L +L +LK FP + K+ +I N + +E ++E Sbjct: 179 VIQNYNEGIIDNLSK--DSLVDLVP-WLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK 235 Query: 256 LDPSAPKDLIDTYLL-HMEKEKSNAHSE-----FSHQNLNLNTLSLFFAGTETTSTTLRY 309 + +++DT + M + NA + S ++ +F AG ETT++ +++ Sbjct: 236 FRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 295 Query: 310 GFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPH 369 +L P V +++Y EI+Q +G R P + DR ++ EA I E+ R + PM +PH Sbjct: 296 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 355 Query: 370 IVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGA--LKKTEAFI 427 +S + + K TEV + L H+ + +PD F P+ FL+ G + + +++ Sbjct: 356 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYL 415 Query: 428 PFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGV 477 PF G R C+GE +AR ELFL +LQ F + P + L V Sbjct: 416 PFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVV 465 >4R1Z-A nrPDB Length = 439 Score = 381 bits (978), Expect = e-106, Method: Composition-based stats. Identities = 118/426 (27%), Positives = 205/426 (48%), Gaps = 13/426 (3%) Query: 70 LGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFR-GYGVIFAN-GNRWKVLRRF 127 +G ++++ +E L+ K + F+GR + D R G + FA+ + WK R+ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 60 Query: 128 SVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKR 187 + FG G S+E+ I EA + E L +S+ + +D N++C++ F Sbjct: 61 VHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSS 120 Query: 188 FHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINA-YIG 246 + D EF ML Y + + L ++F +L+ FP + + I + Sbjct: 121 YKRGDAEFESMLQ--YSQGIVDTVAKDSLVDIFP-WLQIFPNKDLTILRQCISIRDKLLQ 177 Query: 247 HSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSE----FSHQNLNLNTLSLFFAGTET 302 E+H+ T + +DL+D L ++N S + ++ + +F AG ET Sbjct: 178 KKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVET 237 Query: 303 TSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDL 362 T+T L++ ++ P V ++ E++ IG R P+L DR +PY EA I E+ R + Sbjct: 238 TTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPV 297 Query: 363 LPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDA--NGAL 420 P+ +PH+ Q +S Y + K T V + L + HD ++ P+ F+P FL+ +G Sbjct: 298 SPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLC 357 Query: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI 480 + +++PF G R+CLGE +A+ ELFLF ILQ F++ P DL + GV Sbjct: 358 CPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDL-QGKFGVVLQ 416 Query: 481 PPTYQI 486 P +++ Sbjct: 417 PKKFKV 422 >2HI4-A nrPDB Length = 495 Score = 380 bits (976), Expect = e-106, Method: Composition-based stats. Identities = 132/459 (28%), Positives = 222/459 (48%), Gaps = 20/459 (4%) Query: 29 RLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREAL 88 + PP P PLLG++L + + L + R ++YGDV + +G PV++L ++ IR+AL Sbjct: 16 KSPPEPWGWPLLGHVLTLGKNPHL-ALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 74 Query: 89 VDKAEAFSGRGKIAMVDPFFRGYGVIF--ANGNRWKVLRRFSVTTMRDFGMGKR------ 140 V + + F GR + G + F +G W RR + + F + Sbjct: 75 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 134 Query: 141 -SVEERIQEEAQCLIEELRKSKGAL--MDPTFLFQSITANIICSIVFGKRFHYQDQEFLK 197 +EE + +EA+ LI L++ DP AN+I ++ FG+ F E L Sbjct: 135 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 194 Query: 198 MLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL-QEINAYIGHSVEKHRETL 256 ++ ++ SS G + F L+Y P Q +K Q ++ +V++H + Sbjct: 195 LVKNTHEFVETASS--GNPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 251 Query: 257 DPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLK 316 D ++ +D+ H +K + + + + +F AG +T +T + + + ++ Sbjct: 252 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 311 Query: 317 YPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTS 376 P + ++ +E++ VIG R P L DR ++PY EA I E R S LP +PH T+ T+ Sbjct: 312 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 371 Query: 377 FRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK---TEAFIPFSLGK 433 G+ IPK VF+ HDP +E P F P+ FL A+G +E + F +GK Sbjct: 372 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 431 Query: 434 RICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTP 472 R C+GE +A+ E+FLF +LQ + P + +DLTP Sbjct: 432 RRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVK-VDLTP 469 >5VBU-A nrPDB Length = 476 Score = 362 bits (929), Expect = e-100, Method: Composition-based stats. Identities = 120/480 (25%), Positives = 220/480 (45%), Gaps = 23/480 (4%) Query: 20 VQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 79 + + ++ +LP PL L + + L L +K+G ++ +HLG + VV+L Sbjct: 1 MAKKTSSKGKLP------PLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLN 54 Query: 80 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR--WKVLRRFSVTTMRDFGM 137 I EA+V K F+GR + R Y + WK ++ + + + Sbjct: 55 SKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLG-- 112 Query: 138 GKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLK 197 + S+E +++ Q E +R G + F +T +IIC + FG + D Sbjct: 113 IRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKD-DNLMPA 171 Query: 198 MLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAH-RQVYKNLQEINAYIGHSVEKHRETL 256 + S Q+ ++ FL++FP R++ + +++ + + + +H+E+L Sbjct: 172 YYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESL 230 Query: 257 DPSAPKDLIDTYLLHMEK-EKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315 +D++D L + + + ++++ + L GTETT+ TL + + +L Sbjct: 231 VAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLL 290 Query: 316 KYPHVAERVYREIEQVIGPHRP---PELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVT 372 +P + +R+ E++ +GP DRA++P A I E+ R ++P+ +PH T Sbjct: 291 HHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTT 350 Query: 373 QHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLG 432 + +S GY IP+ T + L A D +E+P F PD FL+ K + F G Sbjct: 351 RPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPG----KNSRALAFGCG 406 Query: 433 KRICLGEGIARAELFLFFTTILQNFSMASPVAP-EDIDLTPQECGVGKIPPTYQIRFLPR 491 R+CLGE +AR ELF+ T +LQ F++ + P + K+ P +Q+R PR Sbjct: 407 ARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQP-FQVRLQPR 465 >6IQ5-A nrPDB Length = 463 Score = 360 bits (923), Expect = e-99, Method: Composition-based stats. Identities = 147/457 (32%), Positives = 241/457 (52%), Gaps = 25/457 (5%) Query: 54 SFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGV 113 SF R +YGDVF + LG P+V+L G AI +ALV + AF+ R A G + Sbjct: 6 SFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGRSM 65 Query: 114 IFAN-GNRWKVLRRFSVTTMRDF----GMGKRSVEERIQEEAQCLIEELRKS--KGALMD 166 F + WKV RR + + MR+F ++ +E + EA+ L+ L + GA +D Sbjct: 66 AFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLD 125 Query: 167 PTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKY 226 P L AN++ ++ FG R+ + D EF ++L+ + + + G L ++ +L+Y Sbjct: 126 PRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGA--GSLVDVMP-WLQY 182 Query: 227 FPGAHRQVYKNLQEIN----AYIGHSVEKHRETLDPSA-PKDLIDTYLLHMEK----EKS 277 FP R V++ +++N +I +H E+L P A P+D++D ++L EK + Sbjct: 183 FPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSH 242 Query: 278 NAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRP 337 + +N+ +F A +T ST L++ LL +YP V RV E++QV+G R Sbjct: 243 GGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRL 302 Query: 338 PELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALH 397 P + D+ +PY A +YE RFS +P+ +PH T +TS GY IPKDT VF+ + H Sbjct: 303 PCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNH 362 Query: 398 DPHYFEKPDAFNPDHFLDANGALKK--TEAFIPFSLGKRICLGEGIARAELFLFFTTILQ 455 DP + P+ F+P FLD +G + K T + FS+GKR C+GE +++ +LFLF + + Sbjct: 363 DPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAH 422 Query: 456 NFSM-ASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 A+P P ++ + G+ P ++++ R Sbjct: 423 QCDFRANPNEPAKMNFS---YGLTIKPKSFKVNVTLR 456 >3QZ1-A nrPDB Length = 496 Score = 356 bits (913), Expect = 2e-98, Method: Composition-based stats. Identities = 119/462 (25%), Positives = 215/462 (46%), Gaps = 18/462 (3%) Query: 38 PLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSG 97 PL+ L + + L L +K G V+ + LG + VV+L I EA++ K F+G Sbjct: 32 PLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAG 91 Query: 98 RGKIAMVDPFF-RGYGVIFANGNR-WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIE 155 R +I R + + + WK ++ + + + + S+E + + Q E Sbjct: 92 RPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALLLGT--RSSMEPWVDQLTQEFCE 149 Query: 156 ELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQ 215 +R GA + F +T +IIC + FG + F + +T+ S Q Sbjct: 150 RMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLMKTWDHWS---IQ 206 Query: 216 LFELFSGFLKYFPGAH-RQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEK 274 + ++ FL++FP ++ + ++ + + + +H+E++ +D+ D L + + Sbjct: 207 ILDMVP-FLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQGVGR 265 Query: 275 EKSNAH-SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIG 333 ++ + +++++ + LF GTETT++TL + +L +P + R+ E+++ +G Sbjct: 266 QRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELG 325 Query: 334 PHRP---PELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFL 390 P DRA++P A I E+ R ++P+ +PH T+ +S GY IP+ V Sbjct: 326 PGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIP 385 Query: 391 ILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFF 450 L A D +E+P F PD FL+ + F G R+CLGE +AR ELF+ Sbjct: 386 NLQGAHLDETVWEQPHEFRPDRFLEPGANPSA----LAFGCGARVCLGESLARLELFVVL 441 Query: 451 TTILQNFSMASPVAPEDIDLTPQE-CGVGKIPPTYQIRFLPR 491 +LQ F++ P L P CGV +Q+R PR Sbjct: 442 ARLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRLQPR 483 >6DA2-A nrPDB Length = 487 Score = 335 bits (858), Expect = 4e-92, Method: Composition-based stats. Identities = 108/455 (23%), Positives = 185/455 (40%), Gaps = 20/455 (4%) Query: 32 PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDK 91 PGP PLP LGN+L +G + +KYG V+ + G +PV+ + + I+ LV + Sbjct: 19 PGPTPLPFLGNILSY-HKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 77 Query: 92 A-EAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEA 150 F+ R V F + A WK LR T + + + I + Sbjct: 78 CYSVFTNRRPFGPVG--FMKSAISIAEDEEWKRLRSLLSPTFTSGKL--KEMVPIIAQYG 133 Query: 151 QCLIEELRKSK--GALMDPTFLFQSITANIICSIVFG---KRFHYQDQEFLKMLNLFYQT 205 L+ LR+ G + +F + + ++I S FG + F++ + Sbjct: 134 DVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR- 192 Query: 206 FSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLI 265 F + F + +F + + V+ +E+ ++ SV++ +E+ K + Sbjct: 193 FDFLDPFFLSI-TVFPFLIPILEVLNICVFP--REVTNFLRKSVKRMKESRLEDTQKHRV 249 Query: 266 DTYLLHMEKEKSN---AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAE 322 D L ++ + S +H S L ++ FAG ETTS+ L + + +P V + Sbjct: 250 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 309 Query: 323 RVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYII 382 ++ EI+ V+ PP +M Y + V+ E R + M + + + G I Sbjct: 310 KLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFI 368 Query: 383 PKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIA 442 PK V + DP Y+ +P+ F P+ F N + PF G R C+G A Sbjct: 369 PKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFA 428 Query: 443 RAELFLFFTTILQNFSMASPVAPEDIDLTPQECGV 477 + L +LQNFS P I L G+ Sbjct: 429 LMNMKLALIRVLQNFSFK-PCKETQIPLKLSLGGL 462 >5VEU-A nrPDB Length = 480 Score = 330 bits (846), Expect = 8e-91, Method: Composition-based stats. Identities = 110/455 (24%), Positives = 191/455 (41%), Gaps = 21/455 (4%) Query: 32 PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDK 91 PGP PLPLLGN+L R+GL K +KYG ++ + G PV+ + + IR LV + Sbjct: 18 PGPTPLPLLGNVLSY-RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 76 Query: 92 A-EAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEA 150 F+ R + V F + A WK +R T + + + I + Sbjct: 77 CYSVFTNRRSLGPVG--FMKSAISLAEDEEWKRIRSLLSPTFTSGKL--KEMFPIIAQYG 132 Query: 151 QCLIEELRKS--KGALMDPTFLFQSITANIICSIVFG---KRFHYQDQEFLKMLNLFYQT 205 L+ LR+ KG + +F + + ++I FG + F++ F + Sbjct: 133 DVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK- 191 Query: 206 FSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLI 265 F + +F + LF F + ++ ++ ++ SV + +++ K + Sbjct: 192 FGFLDPLFLSII-LFPFLTPVFEALNVSLFP--KDTINFLSKSVNRMKKSRLNDKQKHRL 248 Query: 266 DTYLLHMEKEKSN---AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAE 322 D L ++ + S +H S L ++ FAG ETTS+ L + + +P V + Sbjct: 249 DFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQ 308 Query: 323 RVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYII 382 ++ +EI+ V+ PP +M Y + V+ E R + + + + G I Sbjct: 309 KLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFI 367 Query: 383 PKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIA 442 PK + V + HDP Y+ +P+ F P+ F ++ + PF G R C+G A Sbjct: 368 PKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI-DPYIYTPFGTGPRNCIGMRFA 426 Query: 443 RAELFLFFTTILQNFSMASPVAPEDIDLTPQECGV 477 + L +LQNFS P I L G+ Sbjct: 427 LMNMKLALIRVLQNFSFK-PCKETQIPLKLDTQGL 460 >5YLW-A nrPDB Length = 495 Score = 326 bits (835), Expect = 1e-89, Method: Composition-based stats. Identities = 112/477 (23%), Positives = 204/477 (42%), Gaps = 41/477 (8%) Query: 3 LSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKY 62 L+ L F+A L +R+ LPPGP P P++GN+LQ+ + F + ++Y Sbjct: 7 LAALFFIAATITFLSFRRRRN------LPPGPFPYPIVGNMLQLGANPH-QVFAKLSKRY 59 Query: 63 GDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMV-----DPFFRGYGVIFAN 117 G + ++HLG V++ E +E L + FSGR V D G+ + Sbjct: 60 GPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFLPV--- 116 Query: 118 GNRWKVLRRFSVTTMRDFGMGKRSVEERI---QEEAQCLIEELRKSK--GALMDPTFLFQ 172 + W+ +R+ M +S+E +++ Q L++ ++K G +D Sbjct: 117 ASEWRDMRKICKEQM----FSNQSMEASQGLRRQKLQQLLDHVQKCSDSGRAVDIREAAF 172 Query: 173 SITANIICSIVFGKRFHYQDQEFLKMLNL-FYQTFSLISSVFG--QLFELFSGFLKYFPG 229 T N++ + +F Q EF + F + ++++ G + F + P Sbjct: 173 ITTLNLMSATLFSS----QATEFDSKATMEFKEIIEGVATIVGVPNFADYFPILRPFDPQ 228 Query: 230 AHRQVYKN-----LQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFS 284 ++ L +I Y+ +E R +P+APK D +L + + Sbjct: 229 GVKRRADVFFGKLLAKIEGYLNERLESKRA--NPNAPKK--DDFLEIVVDIIQANEFKLK 284 Query: 285 HQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRA 344 + L LF G++T +T++ + ++ P R+ E++ V G + + Sbjct: 285 THHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAMP 344 Query: 345 KMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEK 404 K+PY +AVI E+ R P+ +P GY+IPK T++ + DP + Sbjct: 345 KLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTD 404 Query: 405 PDAFNPDHFLDANGALKKTEA-FIPFSLGKRICLGEGIARAELFLFFTTILQNFSMA 460 P+ F+P+ FLD K + +PF G+R+C G +A L + T++ NF Sbjct: 405 PETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWK 461 >6AYB-A nrPDB Length = 466 Score = 322 bits (824), Expect = 3e-88, Method: Composition-based stats. Identities = 100/478 (20%), Positives = 184/478 (38%), Gaps = 31/478 (6%) Query: 20 VQRHPNTHDRLPPG-PRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVML 78 + + ++ +LPP P +P +G+ + + ++ + +KYGDVFT + + + L Sbjct: 1 MAKKTSSKGKLPPRVPNLIPYVGSFVSFAKNP-VQFIIDNSKKYGDVFTATILGKEMTFL 59 Query: 79 CGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRF----SVTTMRD 134 + + S R + P F G GV++ + +++ + S T Sbjct: 60 NHPKILDTFFKATDNELSLRDVYRFMRPVF-GTGVVYDADSTERMMEQVKFVSSGLTTAR 118 Query: 135 FGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHY--QD 192 F + E+ I + + L E +D L + + G + Sbjct: 119 FRVFVDIFEDEIAHKVKELGPE------GTVDVAELMADLIIFTASRCLLGDEVRQYLSE 172 Query: 193 QEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKH 252 + K+ + S +S + L A + V + QE+ +KH Sbjct: 173 KNLGKLYHDIDDGISPLSFFYPSLP------APKRDKARKAVGEIFQELLDKRREEHKKH 226 Query: 253 RETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFL 312 E L + D++D L +K E + + ++ FAG T+S T + + Sbjct: 227 PERLLDESKMDVVDHLLT----QKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLM 282 Query: 313 LMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVT 372 ++ V E+V +E E+++G + + KM Y EA + E R L M + + Sbjct: 283 NVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIM-IMRMAR 341 Query: 373 QHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLG 432 + YIIPK + + S A + PD F+P+ + K +PF G Sbjct: 342 KPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAG 401 Query: 433 KRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPT---YQIR 487 + C+GE A ++ + +L+ F M D T VG PPT Y++R Sbjct: 402 RHKCIGENFALLQVKSIISILLRYFDMEYIGKIPDPSYT--SLVVGPSPPTRMRYKLR 457 >2WX2-A nrPDB Length = 473 Score = 313 bits (801), Expect = 1e-85, Method: Composition-based stats. Identities = 87/452 (19%), Positives = 168/452 (37%), Gaps = 27/452 (5%) Query: 31 PPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVD 90 P P +P LG+++Q + L R+ VFT+ +G + V ++ Sbjct: 19 PVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSP 78 Query: 91 KAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEE 149 + E S R ++ P F G GV +A + +R + + K ++ IQ E Sbjct: 79 RNEILSPREVYTIMTPVF-GEGVAYAAP--YPRMREQLNFLAEELTIAKFQNFVPAIQHE 135 Query: 150 AQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGK--RFHYQDQEFLKMLNLFYQTFS 207 + + E K +++ ++ N C +FG+ R + F ++L+ + Sbjct: 136 VRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSLI 195 Query: 208 LISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDT 267 + L R+ LQ+I I + EK + D + DL+ Sbjct: 196 PAAVFMPWLL----RLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNT-SDLLGG 250 Query: 268 YLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLK--YPHVAERVY 325 L + ++ + S + ++ FAG T++ T + L ++ ++++ Sbjct: 251 LLKAVYRD----GTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLH 306 Query: 326 REIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKD 385 +EI++ + D +MP+ E + E R L + V +V Y++PK Sbjct: 307 KEIDEFPAQLNYDNVMD--EMPFAERCVRESIRRDPPL-LMVMRMVKAEVKVGSYVVPKG 363 Query: 386 TEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAE 445 + + HD F P ++P+ +GA FI F G C+G+ A + Sbjct: 364 DIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGA------FIGFGAGVHKCIGQKFALLQ 417 Query: 446 LFLFFTTILQNFSMASP-VAPEDIDLTPQECG 476 + T + + D D G Sbjct: 418 VKTILATAFREYDFQLLRDEVPDPDYHTMVVG 449 >5JLC-A nrPDB Length = 515 Score = 309 bits (792), Expect = 2e-84, Method: Composition-based stats. Identities = 94/510 (18%), Positives = 182/510 (35%), Gaps = 59/510 (11%) Query: 3 LSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPL-PLLGNLLQMDRRGLLKSFLRFREK 61 + L F+ +T LL +++ PP P +G+ + + + F ++K Sbjct: 16 MVALPFVYTITWQLLYSLRKDR------PPLVFYWIPWVGSAIPYGTKP-YEFFEDCQKK 68 Query: 62 YGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIA-MVDPFFRGYGVIFANGNR 120 YGD+F+ L R + + G + K S + + P F G GVI+ N Sbjct: 69 YGDIFSFMLLGRIMTVYLGPKGHEFIFNAKLADVSAEAAYSHLTTPVF-GKGVIYDCPN- 126 Query: 121 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKG--------ALMDPTFLFQ 172 R + K + + A+ + + R SK ++D Sbjct: 127 ---HRLMEQKKFVKGALTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSGIVDVMVSQP 183 Query: 173 SITANIICSIVFGKRFHYQ-DQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAH 231 +T + GK + D +F + + + F+ I+ VF L P H Sbjct: 184 EMTIFTASRSLLGKEMRDKLDTDFAYLYSDLDKGFTPINFVFPNL-----------PLEH 232 Query: 232 RQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLN 291 + + Q+ + S+ K R + +DLID M+ ++ + Q + Sbjct: 233 YRKRDHAQQAISGTYMSLIKERREKNDIQNRDLIDEL---MKNSTYKDGTKMTDQEIANL 289 Query: 292 TLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPH-RPPELHDRAKMPYTE 350 + + G T++ T + L + + P V E +Y+E +V+ + D MP Sbjct: 290 LIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLN 349 Query: 351 AVIYEIQRFSDLLPMGVPHIVTQHTSF--RGYIIPKDTEVFLILSTALHDPHYFEKPDAF 408 +I E R L + V + + Y++P+D V + +F KP+ F Sbjct: 350 QMIKETLRLHHPLH-SLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEF 408 Query: 409 NPDHFLDANGALKK-----------------TEAFIPFSLGKRICLGEGIARAELFLFFT 451 N + + + ++PF G+ C+GE A +L + + Sbjct: 409 NIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMS 468 Query: 452 TILQNFSMASPVAPEDIDLTPQECGVGKIP 481 ++ P E + + + +P Sbjct: 469 IFIRTMKWRYPTEGETVPPS-DFTSMVTLP 497 >4WMZ-A nrPDB Length = 539 Score = 303 bits (777), Expect = 9e-83, Method: Composition-based stats. Identities = 92/472 (19%), Positives = 167/472 (35%), Gaps = 55/472 (11%) Query: 31 PPGPRPL-PLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALV 89 PP P +G+ + + + F ++KYGD+F+ L R + + G + Sbjct: 56 PPLVFYWIPWVGSAVVYGMKP-YEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFN 114 Query: 90 DKAEAFSGRGKIA-MVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQE 148 K S A + P F G GVI+ N R + K + + + Sbjct: 115 AKLADVSAEAAYAHLTTPVF-GKGVIYDCPNS----RLMEQKKFVKGALTKEAFKSYVPL 169 Query: 149 EAQCLIEELRKSKG--------ALMDPTFLFQSITANIICSIVFGKRFHYQ-DQEFLKML 199 A+ + + R SK +D +T + GK + D +F + Sbjct: 170 IAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLY 229 Query: 200 NLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 259 + + F+ I+ VF L P H + + Q+ + S+ K R + Sbjct: 230 SDLDKGFTPINFVFPNL-----------PLEHYRKRDHAQKAISGTYMSLIKERRKNNDI 278 Query: 260 APKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 319 +DLID+ M+ + + Q + + + G T++ T + L + + P Sbjct: 279 QDRDLIDSL---MKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPD 335 Query: 320 VAERVYREIEQVIGPHRPPELHD-RAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF- 377 V + +Y E +V+ + +D +MP I E R L + V + Sbjct: 336 VQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLH-SLFRKVMKDMHVP 394 Query: 378 -RGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDAN--------------GALKK 422 Y+IP V + YF FN + + + GA+ K Sbjct: 395 NTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISK 454 Query: 423 --TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP----VAPEDI 468 + ++PF G+ C+GE A +L + + ++ P V P D Sbjct: 455 GVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDF 506 >3L4D-A nrPDB Length = 453 Score = 300 bits (768), Expect = 8e-82, Method: Composition-based stats. Identities = 82/458 (17%), Positives = 174/458 (37%), Gaps = 31/458 (6%) Query: 27 HDRLPPGPR-PLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIR 85 +LPP P +G+++Q + L L+ ++KYG +FT+++ + ++ V Sbjct: 1 KGKLPPVVHGTTPFVGHIIQFGKDPL-GFMLKAKKKYGGIFTMNICGNRITVVGDVHQHS 59 Query: 86 EALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEE 144 + + E S R + + P F G GV +A + +R + + K ++ Sbjct: 60 KFFTPRNEILSPREVYSFMVPVF-GEGVAYAAP--YPRMREQLNFLAEELTVAKFQNFAP 116 Query: 145 RIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGK--RFHYQDQEFLKMLNLF 202 IQ E + ++ ++ ++ N C +FG+ R ++F ++L Sbjct: 117 SIQHEVRKFMKANWNKDEGEINILDDCSAMIINTACQCLFGEDLRKRLDARQFAQLLAKM 176 Query: 203 YQTFSLISSVFGQLFELFSGFLKYFPGAHR--QVYKNLQEINAYIGHSVEKHRETLDPSA 260 + + +L P ++R LQ+I + I + EK D + Sbjct: 177 ESCLIPAAVFLPWILKL------PLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNT 230 Query: 261 PKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML--KYP 318 DL+ L + ++ + S + ++ FAG T++ T + L ++ + Sbjct: 231 -SDLLAGLLGAVYRD----GTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNK 285 Query: 319 HVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378 ++++EI++ + + +MP+ E E R L M + V + Sbjct: 286 RHLAKLHQEIDEFPAQLNYDNVME--EMPFAEQCARESIRRDPPLVM-LMRKVLKPVQVG 342 Query: 379 GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLG 438 Y++P+ + + D F P +NP+ + AF F G C+G Sbjct: 343 KYVVPEGDIIACSPLLSHQDEEAFPNPREWNPERNMKLVD-----GAFCGFGAGVHKCIG 397 Query: 439 EGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECG 476 E ++ T+L+++ + + G Sbjct: 398 EKFGLLQVKTVLATVLRDYDFELLGPLPEPNYHTMVVG 435 >6C94-A nrPDB Length = 497 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 92/447 (20%), Positives = 172/447 (38%), Gaps = 32/447 (7%) Query: 32 PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDK 91 PGP L G+ L++ + G L + + +++ + P V G I E D Sbjct: 25 PGPPTHWLFGHALEIQKTGSLDKVVTWTQQFP-----YAHPLWVGQFIGFLNIYEP--DY 77 Query: 92 AEAFSGRGKIAMVDPF-----FRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERI 146 A+A RG D + + G G++ +G +W R+ +T + + K V Sbjct: 78 AKAVYSRGDPKAPDVYDFFLQWIGKGLLVLDGPKWFQHRKL-LTPGFHYDVLKPYVA-IF 135 Query: 147 QEEAQCLIEELRK--SKGALMDPTFLFQSITANIICSIVFGKR---FHYQDQ-------E 194 + + ++E+ K +G D + + + FGK +++D E Sbjct: 136 ADSTRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVAVSE 195 Query: 195 FLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRE 254 ++ +F + L FL+ AH + +++ A + EK RE Sbjct: 196 LTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAALQD--EKERE 253 Query: 255 TLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM 314 + D +D L + + + S +L + F G +TT++ + + M Sbjct: 254 KIQNRRHLDFLDILL----DVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCM 309 Query: 315 LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH 374 YP +R E+ +++G + D AKM Y + E R +P + Sbjct: 310 ALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPV 369 Query: 375 TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434 + G +P + + L + + + P+ F+P F N + + AFIPFS G R Sbjct: 370 SFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPR 429 Query: 435 ICLGEGIARAELFLFFTTILQNFSMAS 461 C+G+ A E+ + L F + Sbjct: 430 NCIGQQFAMNEMKVVTALCLLRFEFSV 456 >3JUS-A nrPDB Length = 461 Score = 291 bits (745), Expect = 4e-79, Method: Composition-based stats. Identities = 88/444 (19%), Positives = 174/444 (39%), Gaps = 23/444 (5%) Query: 19 LVQRHPNTHDRLPPGPR-PLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVM 77 + ++ + PP P+P LG+ + + + + EKYG VF+ + + Sbjct: 1 MAKKTLPAGVKSPPYIFSPIPFLGHAIAFGKSPI-EFLENAYEKYGPVFSFTMVGKTFTY 59 Query: 78 LCGVEAIREALVDKAEAFSGRGKIA-MVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFG 136 L G +A K E + + + P F G GV + N + ++ + + + Sbjct: 60 LLGSDAAALLFNSKNEDLNAEDVYSRLTTPVF-GKGVAYDVPNPVFLEQKKMLKSGLNIA 118 Query: 137 MGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL 196 K+ V I++E + E +S + + + GK Q E + Sbjct: 119 HFKQHV-SIIEKETKEYFESWGESGEK--NVFEALSELIILTASHCLHGKEIRSQLNEKV 175 Query: 197 KMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL 256 Q ++ + F L G+L P R+ + +EI +++K R++ Sbjct: 176 A------QLYADLDGGFSHAAWLLPGWLP-LPSFRRR-DRAHREIKDIFYKAIQKRRQS- 226 Query: 257 DPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLK 316 ++ ID L + + + + L AG T+STT + + + Sbjct: 227 -----QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLAR 281 Query: 317 YPHVAERVYREIEQVIGPHRPPELHDRAK-MPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375 + ++ Y E + V G + PP +D+ K + + I E R + M + + Sbjct: 282 DKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPI-MIMMRMARTPQ 340 Query: 376 SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRI 435 + GY IP +V + + + + FNPD +L N A + A++PF G+ Sbjct: 341 TVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHR 400 Query: 436 CLGEGIARAELFLFFTTILQNFSM 459 C+GE A ++ ++T+L+ + Sbjct: 401 CIGENFAYVQIKTIWSTMLRLYEF 424 >5FSA-A nrPDB Length = 490 Score = 286 bits (732), Expect = 1e-77, Method: Composition-based stats. Identities = 95/482 (19%), Positives = 168/482 (34%), Gaps = 60/482 (12%) Query: 29 RLPPGPRPL-PLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREA 87 + PP P G+ ++ + F R+KYGDVF+ L + + + G + Sbjct: 4 KTPPLVFYWIPWFGSAASYGQQP-YEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFV 62 Query: 88 LVDKAEAFSGRGKIA-MVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERI 146 K S + P F G GVI+ N R F + S + + Sbjct: 63 FNAKLSDVSAEEAYKHLTTPVF-GTGVIYDCPNS----RLMEQKKFAKFALTTDSFKRYV 117 Query: 147 QEEAQCLIEELRKSKG--------ALMDPTFLFQSITANIICSIVFGKRFHYQ-DQEFLK 197 + + ++ + + + IT +FG D+ F + Sbjct: 118 PKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQ 177 Query: 198 MLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQ-EINAYIGHSVEKHRETL 256 + + + F+ I+ VF L P H Q +I+A ++ RE Sbjct: 178 LYSDLDKGFTPINFVFPNL-----------PLPHYWRRDAAQKKISATYMKEIKLRRERG 226 Query: 257 DPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLK 316 D +DLID+ L+H + + Q + + + G T+++T + L + + Sbjct: 227 DIDPNRDLIDSLLIH---STYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGE 283 Query: 317 YPHVAERVYREIEQVI----GPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVT 372 PH+ + +Y+E+ +++ G D K+P I E R L + VT Sbjct: 284 KPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLH-SIFRKVT 342 Query: 373 QHTSF--RGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK-------- 422 YI+PK V + A YF+ P+ F+P + A Sbjct: 343 NPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDE 402 Query: 423 ------------TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPV-APEDID 469 + ++PF G+ C+GE A +L TT + N D D Sbjct: 403 VDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPD 462 Query: 470 LT 471 + Sbjct: 463 YS 464 >3K9V-A nrPDB Length = 482 Score = 285 bits (728), Expect = 4e-77, Method: Composition-based stats. Identities = 113/478 (23%), Positives = 193/478 (40%), Gaps = 40/478 (8%) Query: 32 PGPRPLPLLGNLLQMDRRGLLKS----FLRFREKYGDVFTVHLGPRPVVMLCGVEAIREA 87 PGP PLLG+LL++ +G LK + +KYG +F + LG V L ++ EA Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSP-SLLEA 85 Query: 88 LVDKAEAFSGRGKI----AMVDPFFRGYGVIFANGNRWKVLRR-FSVTTMRDFGMGKRSV 142 L A R +I A D YG++ G W+ +R F M+ + K + Sbjct: 86 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--L 143 Query: 143 EERIQEEAQCLIE---ELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199 +++I E +E EL +G + D + IC +++ KRF +E + Sbjct: 144 DKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEA 203 Query: 200 NLFYQTFSLISSVFGQL----FELFSGFLKYFPGAHRQVYKN-LQEINAYIGHSVEKHRE 254 F + S FG++ EL AH + + + I + ++++ + Sbjct: 204 LTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQ 263 Query: 255 TLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM 314 L D Y S + L L A ETT+ +L + + Sbjct: 264 QPGAD---FLCDIY----------QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNL 310 Query: 315 LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH 374 + P R+ +E++ V+ ++ P D MPY +A + E R + +P + + Sbjct: 311 SRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKP 369 Query: 375 TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434 T Y +PK T + L FE F P+ +L + A +PF +GKR Sbjct: 370 TVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI-NPFAHLPFGIGKR 428 Query: 435 ICLGEGIARAELFLFFTTILQNFS-MASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 +C+G +A +L L I+Q + +A+ P ++ ++P I F PR Sbjct: 429 MCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELP----IAFRPR 482 >2X2N-A nrPDB Length = 475 Score = 282 bits (721), Expect = 3e-76, Method: Composition-based stats. Identities = 84/453 (18%), Positives = 164/453 (36%), Gaps = 29/453 (6%) Query: 31 PPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVD 90 P P +P+LG+++Q + L R+ +FT+++ + V ++ + Sbjct: 19 PVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFFLP 78 Query: 91 KAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEE 149 + E S R + + P F G GV +A + +R + + K ++ IQ E Sbjct: 79 RNEVLSPREVYSFMVPVF-GEGVAYAAP--YPRMREQLNFLAEELTIAKFQNFVPAIQHE 135 Query: 150 AQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGK--RFHYQDQEFLKMLNLFYQTFS 207 + + ++ ++ N C +FG+ R + F ++L + Sbjct: 136 VRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLLAKMESSLI 195 Query: 208 LISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDT 267 + L +L + LQ+I + I + + D S DL+ Sbjct: 196 PAAVFLPILLKL----PLPQSARCHEARTELQKILSEIIIARKAAAVNKDSST-SDLLSG 250 Query: 268 YLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP---HVAERV 324 L + ++ + S + ++ FAG T+S T + L ++ +P E + Sbjct: 251 LLSAVYRD----GTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLM-HPANVKHLEAL 305 Query: 325 YREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPK 384 +EIE+ + D +MP+ E E R L + + V Y++PK Sbjct: 306 RKEIEEFPAQLNYNNVMD--EMPFAERCARESIRRDPPL-LMLMRKVMADVKVGSYVVPK 362 Query: 385 DTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARA 444 + + HD F +P ++P+ GA FI F G C+G+ Sbjct: 363 GDIIACSPLLSHHDEEAFPEPRRWDPERDEKVEGA------FIGFGAGVHKCIGQKFGLL 416 Query: 445 ELFLFFTTILQNFSMASP-VAPEDIDLTPQECG 476 ++ T +++ D D G Sbjct: 417 QVKTILATAFRSYDFQLLRDEVPDPDYHTMVVG 449 >3EL3-A nrPDB Length = 467 Score = 268 bits (686), Expect = 3e-72, Method: Composition-based stats. Identities = 96/441 (21%), Positives = 171/441 (38%), Gaps = 28/441 (6%) Query: 31 PPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVD 90 P +PLLG+ ++ R L +F+ +GDV + LGP+ V + E + AL Sbjct: 25 PVAGGGVPLLGHGWRLARDPL--AFMSQLRDHGDVVRIKLGPKTVYAVTNPE-LTGALAL 81 Query: 91 KAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEA 150 + ++ GV ANG + RR R + + ++EEA Sbjct: 82 NPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAI--PAYGPIMEEEA 139 Query: 151 QCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQE----FLKMLNLFYQTF 206 L E + G +D T + + + R Y D+ + + +F + Sbjct: 140 HALTERWQ--PGKTVDATSESFRVAVRVAARCLL--RGQYMDERAERLCVALATVFRGMY 195 Query: 207 SLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLID 266 + G L+ L P A+R+ L +++ + + + R + P DL+ Sbjct: 196 RRMVVPLGPLYRL------PLP-ANRRFNDALADLHLLVDEIIAERRAS--GQKPDDLLT 246 Query: 267 TYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYR 326 L + K + Q ++ +++ G+ET ++T+ + + +P A+R+ Sbjct: 247 ALL----EAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRD 302 Query: 327 EIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDT 386 E+E V G RP D K+ +T VI E R + + V + + GY IP Sbjct: 303 EVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAE-SELGGYRIPAGA 360 Query: 387 EVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAEL 446 ++ DP ++ F+PD +L A A PFS GKR C + + A+L Sbjct: 361 DIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQL 420 Query: 447 FLFFTTILQNFSMASPVAPED 467 L + + D Sbjct: 421 TLITAALATKYRFEQVAGSND 441 >2W0A-A nrPDB Length = 455 Score = 267 bits (682), Expect = 8e-72, Method: Composition-based stats. Identities = 88/446 (19%), Positives = 166/446 (37%), Gaps = 24/446 (5%) Query: 41 GNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGK 100 G+L + + R R++ GDV T L + VV+L G A + Sbjct: 17 GHLEEFRTDPI-GLMQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKA 75 Query: 101 IAMVDPFFRGYGVIF-ANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRK 159 + P F G V+F A+ R K + +R M + I+++ + +I + Sbjct: 76 YPFMTPIF-GEAVVFDASPERRKEM--LHNAALRGEQMKGHA--ATIEDQVRRMIADW-- 128 Query: 160 SKGALMDPTFLFQSITANIICSIVFGKRFHYQ-DQEFLKMLNLFYQTFSLISSVFGQLFE 218 + +D F +T + + GK+F Q D F K+ + + ++ V L Sbjct: 129 GEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYL-- 186 Query: 219 LFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSN 278 F + + V +N I + + +D++D L+ ++ E Sbjct: 187 PIESFRRRDEARNGLVALVADIMNGRIANPPTDK-------SDRDMLD-VLIAVKAETGT 238 Query: 279 AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP 338 FS + +S+ FAG T+S T + + ++++ V E++++ G R Sbjct: 239 P--RFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSV 296 Query: 339 ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHD 398 H ++P E V+ E R L + + + +G+ I + V + + Sbjct: 297 SFHALRQIPQLENVLKETLRLHPPLII-LMRVAKGEFEVQGHRIHEGDLVAASPAISNRI 355 Query: 399 PHYFEKPDAFNPDHFLDANG-ALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 P F P F P + L +IPF G+ C+G A ++ F+ +L+ + Sbjct: 356 PEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREY 415 Query: 458 SMASPVAPEDIDLTPQECGVGKIPPT 483 PE + V P Sbjct: 416 EFEMAQPPESYRNDHSKMVVQLAQPA 441 >2VE3-A nrPDB Length = 444 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 95/451 (21%), Positives = 175/451 (38%), Gaps = 39/451 (8%) Query: 30 LPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALV 89 +PPG LP LG L G + ++++G +F L + V+ + G A R Sbjct: 13 IPPGDFGLPWLGETLNFLNDGDFGK--KRQQQFGPIFKTRLFGKNVIFISGALANRFLFT 70 Query: 90 DKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEE 149 + E F ++ + G + R+ + S ++ Sbjct: 71 KEQETFQATWPLST-RILLGPNALATQMGEIHRSRRKILYQAFLPRTL--DSYLPKMDGI 127 Query: 150 AQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEF----LKMLNLFYQT 205 Q +E+ K+ + P + +T ++ ++ G++ Q F + LF Sbjct: 128 VQGYLEQWGKANEVIWYPQ--LRRMTFDVAATLFMGEKVSQNPQLFPWFETYIQGLFSLP 185 Query: 206 FSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLI 265 L +++FG + + + A + ++ ++ P + +D + Sbjct: 186 IPLPNTLFG------------------KSQRARALLLAELEKIIKARQQQ--PPSEEDAL 225 Query: 266 DTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVY 325 L + + + S L L L FAG ET ++ L LL+ ++ + ERV Sbjct: 226 GILL----AARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVR 281 Query: 326 REIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKD 385 +E + + + KMPY + V+ E+ R + G + Q F+G+ PK Sbjct: 282 QEQNK-LQLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGF-RELIQDCQFQGFHFPKG 339 Query: 386 TEVFLILSTALHDPHYFEKPDAFNPDHFL-DANGALKKTEAFIPFSLGKRICLGEGIARA 444 V +S DP + P+ F+P+ F D + A +PF G R CLG+ AR Sbjct: 340 WLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARL 399 Query: 445 ELFLFFTTILQNFSMA-SPVAPEDIDLTPQE 474 E+ LF T ++Q F P ++ +TP Sbjct: 400 EMKLFATRLIQQFDWTLLPGQNLELVVTPSP 430 >6CR2-A nrPDB Length = 477 Score = 255 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 84/474 (17%), Positives = 159/474 (33%), Gaps = 53/474 (11%) Query: 29 RLPPGPRPL-PLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREA 87 + PP P +G+ + K F R KYGD+FT L + + G + Sbjct: 4 KTPPVVFHWFPFIGSTISYGIDP-YKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFI 62 Query: 88 LVDKAEAFSGRGKI-AMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK---RSVE 143 L K + P F G V++ N + +G+ RS Sbjct: 63 LNGKLRDVCAEEVYSPLTTPVF-GRHVVYDCPNA----KLMEQKKFVKYGLTSDALRSYV 117 Query: 144 ERIQEEAQCLIEELRKSKG--ALMDPTFLFQSITANIICSIVFGKRFHYQ-DQEFLKMLN 200 I +E + ++ +G + D IT + GK + D F ++ + Sbjct: 118 PLITDEVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEVRSKFDSTFAELYH 177 Query: 201 LFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQ-EINAYIGHSVEKHRETLDPS 259 F+ I+ + P H + Q ++ ++ R+ Sbjct: 178 NLDMGFAPINFMLPWA-----------PLPHNRKRDAAQRKLTETYMEIIKARRQAGSKK 226 Query: 260 APKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 319 +D++ + + + + + ++L AG ++S+T + L + P Sbjct: 227 DSEDMVWNLMSCV----YKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPD 282 Query: 320 VAERVYREIEQVIGPHRPPELHDR-AKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378 + E +Y+E +V+G PP +D K+ VI E R + + V + Sbjct: 283 IMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIH-SIIRAVKNPMAVD 341 Query: 379 G--YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK-------------- 422 G Y+IP V +F P +NP + + A + Sbjct: 342 GTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSK 401 Query: 423 --TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPV---APEDIDLT 471 ++PF G+ C+GE A +L +++ F + D D + Sbjct: 402 GTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVDGIPDTDYS 455 >3MDV-A nrPDB Length = 456 Score = 252 bits (643), Expect = 3e-67, Method: Composition-based stats. Identities = 104/453 (22%), Positives = 177/453 (39%), Gaps = 23/453 (5%) Query: 45 QMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMV 104 ++ R L FL + +KYG V V++ + V++ E++++ L+ + A+ Sbjct: 6 EVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQ 65 Query: 105 DPFFR---GYGVIF-ANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKS 160 F G G++ N RW RR S+ E E+A+ L+E L + Sbjct: 66 TVFGERLFGQGLVSECNYERWHKQRRVIDLAFS--RSSLVSLMETFNEKAEQLVEILE-A 122 Query: 161 KGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELF 220 K P + Q + I+ F + L Q L+ Sbjct: 123 KADGQTPVSM-QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTL 181 Query: 221 SGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSA--PKDLIDTYLLHMEKEKSN 278 + FL R+V ++++ + V++ RE L P D++ L E + Sbjct: 182 AKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ-- 239 Query: 279 AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP 338 + L N ++ F AG ET++ L + + + + P + R+ E+++VIG R Sbjct: 240 -----DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYL 294 Query: 339 ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHD 398 + D ++ Y V+ E R G ++ + T G +P +T + Sbjct: 295 DFEDLGRLQYLSQVLKESLRLYPPAW-GTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRM 353 Query: 399 PHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 458 YFE P FNPD F GA K + PFSLG R C+G+ A+ E+ + +LQ Sbjct: 354 DTYFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE 411 Query: 459 MASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 491 V + L Q P +R PR Sbjct: 412 FRL-VPGQRFGLQEQATLKPLDPVLCTLR--PR 441 >4KPA-A nrPDB Length = 494 Score = 247 bits (631), Expect = 7e-66, Method: Composition-based stats. Identities = 88/438 (20%), Positives = 164/438 (37%), Gaps = 26/438 (5%) Query: 32 PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDK 91 P P+ L NL ++ +++ ++ ++ G++F R L I+EA D+ Sbjct: 30 PQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEA-CDE 88 Query: 92 AEAFSGRGKIAMVDPFFRGYGVI--FANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEE 149 + + F G G+ + + WK + + M + + + Sbjct: 89 SRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAM--KGYHAMMVDI 146 Query: 150 AQCLIEELRKSKGAL-MDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSL 208 A L+++ + ++ +T + I F RF+ ++ Q Sbjct: 147 AVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRD---------QPHPF 197 Query: 209 ISSVFGQLFELFSGFLKYFPG--AHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLID 266 I+S+ L E + + P A+ + + QE + V+K D A + D Sbjct: 198 ITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKI--IADRKASGEQSD 255 Query: 267 TYLLHMEKEKSNAHSE-FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVY 325 L HM K E +N+ ++ AG ETTS L + ++K PHV ++ Sbjct: 256 DLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAA 315 Query: 326 REIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG-YIIPK 384 E +V+ P ++ Y V+ E R P + T G Y + K Sbjct: 316 EEAARVL-VDPVPSYKQVKQLKYVGMVLNEALRLWPTAP-AFSLYAKEDTVLGGEYPLEK 373 Query: 385 DTEVFLILSTALHDPHYF-EKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIAR 443 E+ +++ D + + + F P+ F N + AF PF G+R C+G+ A Sbjct: 374 GDELMVLIPQLHRDKTIWGDDVEEFRPERF--ENPSAIPQHAFKPFGNGQRACIGQQFAL 431 Query: 444 AELFLFFTTILQNFSMAS 461 E L +L++F Sbjct: 432 HEATLVLGMMLKHFDFED 449 >2VZM-A nrPDB Length = 436 Score = 208 bits (529), Expect = 5e-54, Method: Composition-based stats. Identities = 80/474 (16%), Positives = 150/474 (31%), Gaps = 76/474 (16%) Query: 20 VQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLG-PRPVVML 78 ++R PP LG L Q ++ R R + G V V ++ Sbjct: 21 MRRTQQGTTASPPVLD----LGALGQDFAADPYPTYARLRAE-GPAHRVRTPEGNEVWLV 75 Query: 79 CGVEAIREALVDK--AEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFG 136 G + R L D ++ + + ++ ++ R LR+ R+F Sbjct: 76 VGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKL---VAREFT 132 Query: 137 MGKRSV-EERIQEEAQCLIEELRKSKGALMDPTFLFQ-SITANIICSIVFGKRFHYQDQE 194 M + + R+QE L++ + + D + +I E Sbjct: 133 MRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVIS-------------E 179 Query: 195 FLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRE 254 L + F + + F FP Q + E++ Y+ ++ R Sbjct: 180 LLGVPEPDRAAFRVWTDAF------------VFPDDPAQAQTAMAEMSGYLSRLIDSKRG 227 Query: 255 TLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM 314 + L + + S + + L L AG ETT + G + Sbjct: 228 Q--------DGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYAL 279 Query: 315 LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH 374 L +P + RA M + + E+ R+ + + Sbjct: 280 LSHPDQLAAL------------------RADMTLLDGAVEEMLRYEGPVESATYRFPVEP 321 Query: 375 TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434 G +IP V ++L+ A P F P F+ T + F G Sbjct: 322 VDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRR---------DTAGHLAFGHGIH 372 Query: 435 ICLGEGIARAELFLFFTTILQNF-SMASPVAPEDIDLTPQEC--GVGKIPPTYQ 485 C+G +AR E + +L+ +A V+P ++ P G+ +P ++ Sbjct: 373 FCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 426 >5CJE-A nrPDB Length = 393 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 87/452 (19%), Positives = 145/452 (32%), Gaps = 72/452 (15%) Query: 40 LGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVV---MLCGVEAIREALVD-KAEAF 95 LG + RE+ G V V P ++ G E R AL D + Sbjct: 7 LGEYGARFTEDPYPVYAELRER-GPVHWVRTPPPEAFEGWLVVGHEEARAALADPRLSKD 65 Query: 96 SGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEEAQCLI 154 + + +D G ++ + LR R F M + ++ RIQE L+ Sbjct: 66 GTKKGLTSLDVELMGPYLLVVDPPEHTRLRSL---VARAFTMRRVEALRPRIQEITDGLL 122 Query: 155 EE-LRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVF 213 +E L + + L+D + +IC E L + ++ TF +S+ Sbjct: 123 DEMLPRGRADLVD--SFAYPLPITVIC-------------ELLGVPDIDRVTFRALSNEI 167 Query: 214 GQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHME 273 P + + AY+ ++ R T AP D + L+ Sbjct: 168 ------------VAPTGGDAELAAYERLAAYLDELIDDKRST----APADDLLGDLIRTR 211 Query: 274 KEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIG 333 E + S + L L AG ETT + G +L +P + Sbjct: 212 AEDDD---RLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAAL--------- 259 Query: 334 PHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILS 393 RA M + + E+ RF + + G I + V + L Sbjct: 260 ---------RADMTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLD 310 Query: 394 TALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTI 453 A DP P F+ + + F G CLG +AR E + ++ Sbjct: 311 AAGRDPARHPDPHVFDIHR---------APQGHLAFGHGIHYCLGAPLARLEARVALRSL 361 Query: 454 LQNF-SMASPVAPEDIDLTPQECGVGKIPPTY 484 L+ +A P GV ++P + Sbjct: 362 LERCPDLALDGPPGARPPGMLIRGVRRLPVRW 393 >4OQS-A nrPDB Length = 433 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 89/469 (18%), Positives = 156/469 (33%), Gaps = 92/469 (19%) Query: 34 PRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLG-PRPVVMLCGVEAIREALVDKA 92 P LP G + K V + ++ A R ++D Sbjct: 11 PVTLP-TGRAVGYPFDPPPDLV-----KLPPVSPMRFPDGHIGWLVTSHAAARTVMIDPR 64 Query: 93 EAFSGRGKI--AMVDPFFRGYGVIFANGNRW------KVLRRFSVTTMRDFGMGK-RSVE 143 FS R + + R G A W R+ + F + + + +E Sbjct: 65 --FSNRPEHKHPVFSVIPRPGGATKAPAPGWFINMDAPEHTRYRRMLISQFTVRRIKELE 122 Query: 144 ERIQEEAQCLIEELRKSKGALMDPTFLFQ-SITANIICSIVFGKRFHYQDQEFLKMLNLF 202 RI + + ++ + K+ G +D F + + +IC ++ Y D F F Sbjct: 123 PRIVQITEDHLDAMAKA-GPPVDLVQAFALPVPSLVICELL---GVSYADHAF------F 172 Query: 203 YQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPK 262 + ++++SV +V L ++ YI V R + PK Sbjct: 173 QEQTTIMASV---------------DKTQDEVTTALGKLTRYIAELVATKRLS-----PK 212 Query: 263 DLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAE 322 D + L+ ++ + + L L L AG ETT+ L G +L++P Sbjct: 213 DDLLGSLI--------TDTDLTDEELTNIALLLLVAGHETTANMLGLGTFALLQHPEQIA 264 Query: 323 RVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVP-HIVTQHTSFRGYI 381 + + E+ R+ ++ +G P + G + Sbjct: 265 ALDS-----------------------PDAVEELLRYLSIVHLGTPNRAALEDVELEGQM 301 Query: 382 IPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGI 441 I K V + L DP F++PD D F G CLG+ + Sbjct: 302 IRKGDTVAIGLPAVNRDPKVFDEPDILQLDR--------VDARKHAAFGGGIHQCLGQQL 353 Query: 442 ARAELFLFFTTILQNFS-MASPVAPEDIDLTPQE--CGVGKIPPTYQIR 487 AR E+ + FT + F + V E+I L + GV +P + R Sbjct: 354 ARVEMRIGFTRLFARFPSLRLAVPAEEIKLREKSAAYGVWALPVAWDAR 402 >3N9Z-A nrPDB Length = 487 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 82/456 (17%), Positives = 162/456 (35%), Gaps = 29/456 (6%) Query: 22 RHPNTHDRLP-PGPRPLPLLGNLL-QMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 79 R P + +P PG L + + + ++ +KYG ++ LG V + Sbjct: 3 RSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVI 62 Query: 80 GVEAIREALVDKA---EAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFG 136 E + + E F +A + R GV+ WK R ++ Sbjct: 63 DPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDR-VALNQEVMAP 121 Query: 137 MGKRSVEERIQEEAQCLIEELRK------SKGALMDPTFLFQSITANIICSIVFGKRFHY 190 ++ + ++ + L + S D + I +++FG+R Sbjct: 122 EATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGM 181 Query: 191 Q----DQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKN-LQEINAYI 245 + E + ++ YQ F + +LF F H + + + Y Sbjct: 182 LEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYT 241 Query: 246 GHSVEKHRETLDPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTS 304 + + R+ + ++ L S+ S +++ N + G +TTS Sbjct: 242 QNFYWELRQKGSVHHDYRGILYRLL---------GDSKMSFEDIKANVTEMLAGGVDTTS 292 Query: 305 TTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLP 364 TL++ M + V + + E+ + +P +A I E R + Sbjct: 293 MTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPIS- 351 Query: 365 MGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTE 424 + + + R Y+IP T V + + +P +F P+ F+P +L + + Sbjct: 352 VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFR 411 Query: 425 AFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMA 460 + F G R CLG IA E+ +F +L+NF + Sbjct: 412 N-LGFGWGVRQCLGRRIAELEMTIFLINMLENFRVE 446 >4OQR-A nrPDB Length = 457 Score = 197 bits (501), Expect = 8e-51, Method: Composition-based stats. Identities = 85/468 (18%), Positives = 148/468 (31%), Gaps = 92/468 (19%) Query: 34 PRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLG-PRPVVMLCGVEAIREALVDKA 92 P LP G + K V + ++ A R ++D Sbjct: 50 PVTLP-TGRAVGYPFDPPPDLV-----KLPPVSPMRFPDGHIGWLVTSHAAARTVMIDPR 103 Query: 93 EAFSGRGKI--AMVDPFFRGYGVIFANGNRW------KVLRRFSVTTMRDFGMGK-RSVE 143 FS R + + R G A W R+ + F + + + +E Sbjct: 104 --FSNRPEHKHPVFSVIPRPGGATKAPAPGWFTNMDAPEHTRYRRMLISQFTVRRIKELE 161 Query: 144 ERIQEEAQCLIEELRKSKGALMDPTFLFQ-SITANIICSIVFGKRFHYQDQEFLKMLNLF 202 RI + ++ + K+ G +D F + + +IC ++ Y D F + Sbjct: 162 PRIVRITEDHLDAMAKA-GPPVDLVQAFALPVPSLVICELL---GVSYADHAFFQEQTTI 217 Query: 203 YQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPK 262 + +V L ++ YI V R + PK Sbjct: 218 MVSVD---------------------KTQDEVTTALGKLTRYIAELVATKRLS-----PK 251 Query: 263 DLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAE 322 D + L+ ++ + + L L L AG ETT+ L G +L++P Sbjct: 252 DDLLGSLI--------TDTDLTDEELTNIALILLVAGHETTANMLGLGTFALLQHPEQIA 303 Query: 323 RVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVP-HIVTQHTSFRGYI 381 + + E+ R+ ++ +G P + G + Sbjct: 304 NLDS-----------------------PDAVEELLRYLSIVHLGTPNRAALEDVELEGQM 340 Query: 382 IPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGI 441 I K V + L DP F++PD D F G CLG+ + Sbjct: 341 IRKGDTVAIGLPAVNRDPKVFDEPDILQLDR--------VDARKHAAFGGGIHQCLGQQL 392 Query: 442 ARAELFLFFTTILQNFS-MASPVAPEDIDLTPQE--CGVGKIPPTYQI 486 AR E+ + FT + F + V E+I L + GV +P + Sbjct: 393 ARVEMRIGFTRLFARFPSLRLAVPAEEIKLREKSAAYGVWALPVAWDA 440 >2Z36-A nrPDB Length = 413 Score = 197 bits (501), Expect = 9e-51, Method: Composition-based stats. Identities = 62/367 (16%), Positives = 123/367 (33%), Gaps = 66/367 (17%) Query: 123 VLRRFSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQ-SITANIIC 180 + +F + + ++ RIQ+ I+++ + +D + + +IC Sbjct: 102 EHSAARRPVIGEFTVKRLAALRPRIQDIVDHFIDDMLATDQRPVDLVQALSLPVPSLVIC 161 Query: 181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE 240 ++ Y D +F + + + + + E Sbjct: 162 ELL---GVPYTDHDFFQSRTTMMVSRTSM----------------------EDRRRAFAE 196 Query: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300 + AYI + + S P D + + + ++++ H L L AG Sbjct: 197 LRAYIDDLITRKE-----SEPGDDLFSRQIARQRQE----GTLDHAGLVSLAFLLLTAGH 247 Query: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360 ETT+ + G + +L +P V P R P + E+ R+ Sbjct: 248 ETTANMISLGVVGLLSHPEQLTVVK------ANPGRTP------------MAVEELLRYF 289 Query: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420 + + T+ G I V + + +A DP F+ P + + Sbjct: 290 TIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVER-------- 341 Query: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPEDIDLTPQE--CGV 477 + F G CLG+ +AR EL + F T+ + + V ED+ GV Sbjct: 342 -GARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAVPMEDVPFKGDSVIYGV 400 Query: 478 GKIPPTY 484 ++P T+ Sbjct: 401 HELPVTW 407 >4UBS-A nrPDB Length = 393 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 77/423 (18%), Positives = 140/423 (33%), Gaps = 75/423 (17%) Query: 72 PRPVVMLCGVEAIREALVDKAEAFSGR--GKIAMVDPFFRGY-----GVIFANGNRWKVL 124 R V ++ G A R AL+ S R + F ++ + + Sbjct: 36 GRSVWVVTGHAAAR-ALLSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGVDDPEHRTQ 94 Query: 125 RRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVF 184 RR V + ++ RIQE L++ + + + + +IC+++ Sbjct: 95 RRMLVPSFTLKRAA--ALRPRIQETVDGLLDAMEAQGPPAELVSAFALPLPSMVICALL- 151 Query: 185 GKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAY 244 Y D +F FE S L PG +V +++ Y Sbjct: 152 --GVPYADHDF---------------------FESQSRRLLRGPGIA-EVQDARAQLDDY 187 Query: 245 IGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTS 304 + +++ R+ DLI ++ L L AG ETT+ Sbjct: 188 LYALIDRKRKEPGDGLLDDLI---------QEQLNRGTVDRAELVSLATLLLIAGHETTA 238 Query: 305 TTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLP 364 + G +L++P + E A + E+ RF + Sbjct: 239 NMISLGTFTLLRHPEQLAELRAEPG------------------LMPAAVEELLRFLSIAD 280 Query: 365 MGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTE 424 G+ + T+ G I D V S D F +PDA + + Sbjct: 281 -GLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALD---------WHRSAR 330 Query: 425 AFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPEDIDLTPQEC--GVGKIP 481 + F G CLG+ +ARAE+ + T+ + + ++I P + G+ ++P Sbjct: 331 HHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADEIPFKPGDTIQGMLELP 390 Query: 482 PTY 484 T+ Sbjct: 391 VTW 393 >3MZS-A nrPDB Length = 486 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 83/485 (17%), Positives = 155/485 (31%), Gaps = 33/485 (6%) Query: 22 RHPNTHDRLP-PGPRPLPLLGNLL-QMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 79 + P + +P PG L + + + + + +KYG ++ LG V + Sbjct: 5 KTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYII 64 Query: 80 GVEAIREALVDKAE--AFSGRGKIAMVDPFFRGY-GVIFANGNRWKVLRRFSVTTMRDFG 136 E + + +++ GV+F WK R + T Sbjct: 65 HPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDR-VVLNTEVMAP 123 Query: 137 MGKRSVEERIQEEAQCLIEELRK-----SKGALM-DPTFLFQSITANIICSIVFGKRFHY 190 ++ + +Q + L K G + D I +++FG+R Sbjct: 124 EAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGM 183 Query: 191 QDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQV-----YKNLQEINAYI 245 ++ F + L + + F + + Y Sbjct: 184 LEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYT 243 Query: 246 GHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTST 305 + R + ++ L + +++ N + G TTS Sbjct: 244 EIFYQDLRRKTEFRNYPGILYCLL---------KSEKMLLEDVKANITEMLAGGVNTTSM 294 Query: 306 TLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPM 365 TL++ M + +V E + E+ +P +A I E R + + Sbjct: 295 TLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPIS-V 353 Query: 366 GVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEA 425 + + Y+IP T V + + DP +F PD F+P +L + L Sbjct: 354 TLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRN 413 Query: 426 FIPFSLGKRICLGEGIARAELFLFFTTILQNFSMA-----SPVAPEDIDLTPQECGVGKI 480 + F G R C+G IA E+ LF IL+NF + ++ LTP + Sbjct: 414 -LGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVF 472 Query: 481 PPTYQ 485 P Q Sbjct: 473 RPFNQ 477 >4YZR-A nrPDB Length = 405 Score = 194 bits (493), Expect = 8e-50, Method: Composition-based stats. Identities = 73/382 (19%), Positives = 137/382 (35%), Gaps = 65/382 (17%) Query: 105 DPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGAL 164 D F ++ + LR + ++ I++ A+ L++E+ K A Sbjct: 83 DIDFVSDHMLAKDTPDHTRLRSLVHQAFTPRTI--ENLRGSIEQIAEQLLDEMEKENKAD 140 Query: 165 MDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFL 224 + + +I E + + F + ++ E Sbjct: 141 I-MKSFASPLPFIVIS-------------ELMGIPKEDRSQFQIWTNAMVDTSE------ 180 Query: 225 KYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFS 284 G + L+E YI + R PKD + + L+H E S+ S Sbjct: 181 ----GNRELTNQALREFKDYIAKLIHDRR-----IKPKDDLISKLVHAE----ENGSKLS 227 Query: 285 HQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRA 344 + L L AG ETT L G L +L++ E++ ++ E + Sbjct: 228 EKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIA------------ 275 Query: 345 KMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEK 404 + E+ R++ + M + +++G+ I + +F+ + +A DP++FE Sbjct: 276 ------TAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFEN 329 Query: 405 PDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF-SMASPV 463 P+ N + I F G CLG +AR E + F +L+ F + V Sbjct: 330 PEILNINR---------SPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAV 380 Query: 464 APEDIDLTPQEC--GVGKIPPT 483 AP+DI G+ +P + Sbjct: 381 APDDIQWRKNVFLRGLESLPVS 402 >5EX6-C nrPDB Length = 434 Score = 194 bits (492), Expect = 9e-50, Method: Composition-based stats. Identities = 75/441 (17%), Positives = 142/441 (32%), Gaps = 87/441 (19%) Query: 63 GDVFTVHLGP----RPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFA-- 116 G++ V LG + G + +R+ L D FS R + D G GV Sbjct: 62 GELTRVRLGSGADAEHTWLATGHDVVRQVLGDHTR-FSTRRRFDRNDEI-GGKGVFRPRE 119 Query: 117 --------NGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPT 168 + LRR + R + I++ ++E+ + G+ D Sbjct: 120 LVGNLMDYDPPEHTRLRRLLAPGFTHRKI--RRMAPYIEQIVTERLDEMERE-GSPADLI 176 Query: 169 FLFQ-SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYF 227 LF + ++C ++ D+ + Sbjct: 177 ELFADEVPGPVLCELL---GVPRDDRAM------------------------------FL 203 Query: 228 PGAHRQVYKNLQ-EINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQ 286 HR + +L A G + ++ T+ KD D + + E + + + Sbjct: 204 QLCHRHLDASLSGRRRAAAGEAFSRYLVTMVARERKDPGDGLIGMVVAEHGDT---VTDE 260 Query: 287 NLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKM 346 L + + AG + S + G L +L+ P + R + Sbjct: 261 ELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAAL------------------RGDV 302 Query: 347 PYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPD 406 P E + E+ R+ + P + ++ +I V L TA DP D Sbjct: 303 PAAERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDAD 362 Query: 407 AFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS---MASPV 463 + ++ + F G CLG +AR EL + +T + + F +A P Sbjct: 363 RLD---------VTREAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADPD 413 Query: 464 APEDIDLTPQECGVGKIPPTY 484 + L+ G+ ++ T+ Sbjct: 414 GATEFRLSTPAYGISRLMVTW 434 >5L94-A nrPDB Length = 410 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 68/387 (17%), Positives = 129/387 (33%), Gaps = 57/387 (14%) Query: 73 RPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTM 132 R V + + ++E L K S R G +I + + +R Sbjct: 44 RQVWDVFHYDGVKEVLEQKNIFSSDRRPPQNQRQTALGTSLINIDPPKHAEMRALVNKAF 103 Query: 133 RDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQ-SITANIICSIVFGKRFHYQ 191 M ++ E +I L++E+ + +D + +I I+ + Sbjct: 104 TPKAM--KAWEPKIARITNELLQEVEHLED--IDIVEHLSYPLPVMVIADIL---GVPIE 156 Query: 192 DQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEK 251 DQ F S + + + + ++ K E+ Y +E+ Sbjct: 157 DQR----------QFKDWSDII--VAGPSNNERETLEKLQQEKMKANDELETYFYRIIEE 204 Query: 252 HRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGF 311 R P D I + LL ++E + + + + ++ L AG ETT+ + Sbjct: 205 KRTR-----PGDDIISVLLQAKEE----GKQLTDEEIVGFSILLLIAGNETTTNLISNTI 255 Query: 312 LLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIV 371 +++ ER+ RE E + I E+ R+ + + IV Sbjct: 256 YCLMEDKASFERLKREKE------------------LLPSGIEEVLRYRSPVQ-ALHRIV 296 Query: 372 TQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSL 431 + + G + V + +A D YFE P+ F D K + F Sbjct: 297 KEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR---------KPNVHMAFGR 347 Query: 432 GKRICLGEGIARAELFLFFTTILQNFS 458 G CLG +AR E + ++ + Sbjct: 348 GIHFCLGAPLARIEAKIMLAELIDRYP 374 >2ZBZ-A nrPDB Length = 412 Score = 191 bits (484), Expect = 8e-49, Method: Composition-based stats. Identities = 77/446 (17%), Positives = 143/446 (32%), Gaps = 77/446 (17%) Query: 51 LLKSFLRFREKYGDVFTVHLG-PRPVVMLCGVEAIREALVDKAEAFSGRGK--IAMVDPF 107 L + + R+ G + V L R ++ EA R+ L D S R P Sbjct: 26 LPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGD-PRLSSNRTDDNFPATSPA 84 Query: 108 FRG-----YGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRKSK 161 F I + RR T+ +F + + + + ++E ++E+ + Sbjct: 85 FEAVRESPQAFIGLDPPEHGTRRRM---TISEFTVKRIKGMRPEVEEVVHGFLDEMLAAG 141 Query: 162 GALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFS 221 + + + +IC ++ Y D EF F S Q + S Sbjct: 142 PTADLVSQFALPVPSMVICRLL---GVPYADHEF----------FQDASKRLVQSTDAQS 188 Query: 222 GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHS 281 ++ Y+ + + + L+ A+ Sbjct: 189 ------------ALTARNDLAGYLDGLITQFQTEP---------GAGLVGALVADQLANG 227 Query: 282 EFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELH 341 E + L + L AG ETT++ + +L +P + + V G Sbjct: 228 EIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPG-------- 279 Query: 342 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 401 + E+ R+ + + + T G +I V ++ S A D Sbjct: 280 ----------AVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTV 329 Query: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MA 460 +E PDA + + F G CLG+ +AR EL + ++ + Sbjct: 330 YEDPDALDIHR---------SARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLR 380 Query: 461 SPVAPEDIDLTPQEC--GVGKIPPTY 484 V E + L P GV ++P T+ Sbjct: 381 LAVPVEQLVLRPGTTIQGVNELPVTW 406 >2Y5N-A nrPDB Length = 417 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 68/388 (17%), Positives = 129/388 (33%), Gaps = 67/388 (17%) Query: 102 AMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSK 161 P G++ + LRR V S+ R +E A L++++ + Sbjct: 92 PRTRPEMVKGGLLSMDPPEHSRLRRLVVKAFT--ARRAESLRPRAREIAHELVDQMAAT- 148 Query: 162 GALMDPTFLFQS-ITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELF 220 G D +F + +IC E L + + + F+ S F E+ Sbjct: 149 GQPADLVAMFARQLPVRVIC-------------ELLGVPSADHDRFTRWSGAFLSTAEV- 194 Query: 221 SGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAH 280 ++ + ++ AY+G +++ R+ P D + + L+ ++ + Sbjct: 195 ---------TAEEMQEAAEQAYAYMGDLIDRRRK-----EPTDDLVSALVQARDQQDS-- 238 Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 S Q L + L AG E+T+T + L++ P + ++ Sbjct: 239 --LSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTRPELRRQL---------------- 280 Query: 341 HDRAKMPYTEAVIYEIQRFSDL-LPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDP 399 + + + E+ R+ L + P + + RG I V A D Sbjct: 281 --LDRPELIPSAVEELTRWVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQ 338 Query: 400 HYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSM 459 F D + D + F G CLG +AR EL + +LQ Sbjct: 339 AQFPDADRIDVDR---------TPNQHLGFGHGVHHCLGAPLARVELQVALEVLLQRLPG 389 Query: 460 ASPVAPED-IDLTPQEC--GVGKIPPTY 484 PE + + G ++P + Sbjct: 390 IRLGIPETQLRWSEGMLLRGPLELPVVW 417 >3SN5-A nrPDB Length = 491 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 90/500 (18%), Positives = 163/500 (32%), Gaps = 51/500 (10%) Query: 20 VQRHPNTHDRL---PPGPRPL-PLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPV 75 + + ++ R PP L P LG LQ L + + K+G VFT L + V Sbjct: 1 MAKKTSSRRRQTGEPPLENGLIPYLGCALQFGANPL-EFLRANQRKHGHVFTCKLMGKYV 59 Query: 76 VMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDF 135 + + + L + A+ F + +GN + + + T++ Sbjct: 60 HFITNPLSYHKVLCHGKYFDWKKFHFALSAKAFGHRSIDPMDGNTTENINDTFIKTLQGH 119 Query: 136 GMGK--RSVEERIQEEAQCLIEELRKSKGALMD-PTFLFQSITANIICSIVFGKRFHYQD 192 + S+ E +Q + + K+ + + + +FG+ +D Sbjct: 120 ALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRD 179 Query: 193 QEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKH 252 + +LN F VF L + F AH K + + +++K Sbjct: 180 TQKAHILNNLD-NFKQFDKVFPALVAGLP--IHMFRTAHNAREKLAESLRH---ENLQKR 233 Query: 253 RETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFL 312 + + + ++ L S F L + +A T + Sbjct: 234 ESISELISLRMFLNDTL-----------STFDDLEKAKTHLVVLWASQANTIPATFWSLF 282 Query: 313 LMLKYPHVAERVYREIEQVI----------GPHRPPELHDRAKMPYTEAVIYEIQRFSDL 362 M++ P + E+++ + G + +P +++I E R S Sbjct: 283 QMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSA 342 Query: 363 LPMGVPHIVTQHTSF----RGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANG 418 + + Y I KD + L DP + P F D +LD NG Sbjct: 343 --SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENG 400 Query: 419 ALKKT---------EAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVA-PEDI 468 K T ++PF G IC G A E+ F +L F + + Sbjct: 401 KTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCP 460 Query: 469 DLTPQECGVGKIPPTYQIRF 488 L G+G +PP I F Sbjct: 461 PLDQSRAGLGILPPLNDIEF 480 >3EJB-B nrPDB Length = 404 Score = 188 bits (476), Expect = 6e-48, Method: Composition-based stats. Identities = 68/432 (15%), Positives = 138/432 (31%), Gaps = 70/432 (16%) Query: 64 DVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYG------VIFAN 117 ++ P + G E A + K F R + ++ ++F N Sbjct: 27 PIYKGSFLKYPGWYVTGYE--ETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQN 84 Query: 118 GNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITAN 177 + LR + S + I E L+++++ K + + + + Sbjct: 85 QPDHRRLRTLASGAFTP--RTTESYQPYIIETVHHLLDQVQGKKKMEV-ISDFAFPLASF 141 Query: 178 IICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKN 237 +I +I+ + + ++ Q + F+ K + + Sbjct: 142 VIANII-------------GVPEEDREQLKEWAASLIQTID-FTRSRKALTEGNIMAVQA 187 Query: 238 LQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFF 297 + Y ++K + +D+I L EK+K + + + L Sbjct: 188 MA----YFKELIQKRKR----HPQQDMISMLLKGREKDK------LTEEEAASTCILLAI 233 Query: 298 AGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQ 357 AG ETT + L +L++P ++ + + E Sbjct: 234 AGHETTVNLISNSVLCLLQHPEQLLKLRENPD------------------LIGTAVEECL 275 Query: 358 RFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDAN 417 R+ M + ++ G I + +V+L+L A DP F PD F+ Sbjct: 276 RYESPTQM-TARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITR----- 329 Query: 418 GALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTP--QEC 475 + F G +CLG +AR E + T+LQ + E P Sbjct: 330 ----SPNPHLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFE-WRYRPLFGFR 384 Query: 476 GVGKIPPTYQIR 487 + ++P T++ Sbjct: 385 ALEELPVTFEAS 396 >5VWS-A nrPDB Length = 393 Score = 188 bits (476), Expect = 7e-48, Method: Composition-based stats. Identities = 76/422 (18%), Positives = 135/422 (31%), Gaps = 64/422 (15%) Query: 64 DVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKV 123 V+ G + + + +R+ L D S R ++ F G+ + + Sbjct: 32 PVWRDQFG---IYHVFRYDDVRQILGDYQTFSSDRTRLMPTAQGFGKGGITMIDPPEHRH 88 Query: 124 LRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQ-SITANIICSI 182 RR + ++E RI++ A L++EL G D F + +I + Sbjct: 89 QRRLITHAFTPQSIS--AMEPRIRQIADHLLDEL---PGPEFDLVEHFAYPLPVIVIAEL 143 Query: 183 VFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEIN 242 + D+ + + + + + P R V + E+N Sbjct: 144 L---GVPPGDRHLFRTWSDRLMSLQVENYAD--------------PELARTVAAAMTEMN 186 Query: 243 AYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTET 302 Y+ R + P+D + T L+ E E + + L AG T Sbjct: 187 DYLREHCRSRR-----THPRDDLLTRLVQAEVE----GKRLDLEEVVNTASLLLLAGHLT 237 Query: 303 TSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDL 362 T+ + L + +P + V RA A + E R Sbjct: 238 TTVLIGNTMLCLWDHPEAEKAV------------------RADPSLIPAALEESLRLRSP 279 Query: 363 LPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK 422 + + T+ + G IP + V + +A HD F P+ F+ + Sbjct: 280 F-LQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHR---------Q 329 Query: 423 TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQEC-GVGKIP 481 T I F G CLG + R E + +L F+ P E I G ++P Sbjct: 330 TTGHIAFGHGVHFCLGAQLGRLEGRIALERLLGRFTEIHPWPREGISFYQSAIFGASRMP 389 Query: 482 PT 483 Sbjct: 390 VR 391 >3MGX-A nrPDB Length = 415 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 73/381 (19%), Positives = 126/381 (33%), Gaps = 67/381 (17%) Query: 108 FRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDP 167 G ++ + + + LR+ + R + ER++ E ++ R G + D Sbjct: 101 SGGRMMVVSEHEQHRKLRKLVGPLLS--RAAARKLAERVRIEVGDVL--GRVLDGEVCDA 156 Query: 168 -TFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKY 226 T + I A ++C I+ +D++ L L + FG ELF G Sbjct: 157 ATAIGPRIPAAVVCEIL---GVPAEDEDML---------IDLTNHAFGGEDELFDGMTP- 203 Query: 227 FPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQ 286 + EI Y + R+ P D + + L+ + + Sbjct: 204 --------RQAHTEILVYFDELITARRK-----EPGDDLVSTLV--------TDDDLTID 242 Query: 287 NLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKM 346 ++ LN ++ G ETT + + P + + V Sbjct: 243 DVLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTALRDGSADV--------------- 287 Query: 347 PYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPD 406 + V+ E+ R++ M V + T + G +P T V L A DP F+ PD Sbjct: 288 ---DTVVEEVLRWTSPA-MHVLRVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPD 343 Query: 407 AFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPE 466 F P K I F G CLG +AR EL + + + S Sbjct: 344 TFLPGR---------KPNRHITFGHGMHHCLGSALARIELSVVLRVLAERVSRVDLEREP 394 Query: 467 DIDLTPQECGVGKIPPTYQIR 487 G ++P + R Sbjct: 395 AWLRAIVVQGYRELPVRFTGR 415 >5Y1I-A nrPDB Length = 403 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 69/389 (17%), Positives = 122/389 (31%), Gaps = 71/389 (18%) Query: 101 IAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKS 160 ++M P F G + +RR T+ ++ IQ+ LI+ + Sbjct: 81 LSMAQPSFAGQ-----DDPEHGRIRRMV--TLPFTARRIEAMRPAIQKITDELIDGMLAG 133 Query: 161 KGALMDPTFLFQ-SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFEL 219 +D + +IC ++ Y+D+EFL+ N Sbjct: 134 P-KPVDLVEALALPVPVRVICEML---GVPYEDREFLQQNN------------------- 170 Query: 220 FSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNA 279 + Y A K Y+ V T D++ + +E Sbjct: 171 --NAMIYRDTAQGDAQKAAIAQAMYLKELV----GTKLGDRGDDILSDLAVQVEA----- 219 Query: 280 HSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPE 339 E + + + L AG ETT+ + G L +L+ P V Sbjct: 220 -GEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPEQLAEVR-------------- 264 Query: 340 LHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDP 399 D + E+ R+ + V I + G +I + L+ A DP Sbjct: 265 --DSDDPKVIVNTVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDP 322 Query: 400 HYFEK-PDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 458 + + PD + + F G CLG +AR EL + ++T+L+ Sbjct: 323 DLYPEAPDRLDIHR--------ANARRHLAFGYGVHQCLGATLARVELQIVYSTLLRRIP 374 Query: 459 MASPVAPED---IDLTPQECGVGKIPPTY 484 + D GV ++P T+ Sbjct: 375 TLALAGTLDEIPFKHDQIAHGVYELPVTW 403 >4GGV-A nrPDB Length = 418 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 75/443 (16%), Positives = 137/443 (30%), Gaps = 68/443 (15%) Query: 42 NLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKI 101 +L +R + V+ V+ P + +L + + + Sbjct: 35 HLWLRGQRPESPVVFDETQ---GVWNVYGYPEAMDILNDHDTFT-------SDLAHLLPV 84 Query: 102 AMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSK 161 ++ P G + + R + R+ + +E R+ + + L++ + Sbjct: 85 SVDAPLLEG-DMSQMDPPRHRKYRQLVSRAFTPRLVAD--METRVADITRELLDAVDGKP 141 Query: 162 GALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFS 221 + L + +I ++ D++ F + + F FS Sbjct: 142 EIEIAA-DLAYPLPVIVIAELL---GVPAGDRDL----------FKKWADDIIEGFSGFS 187 Query: 222 GFLKYFPGAH--RQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNA 279 G R + L+ + Y+ V + R T P++ + T+L+ E + Sbjct: 188 FLDTSGQGEQDVRDATERLRPLLDYMAGHVTERRRT-----PREDLLTHLVQAEVD---- 238 Query: 280 HSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPE 339 + + L G TT+ TL L + P VA +V + V G Sbjct: 239 GERLTDNEIVNVANILLVTGHITTTMTLGNTVLCLDADPEVAAKVRADRSLVPG------ 292 Query: 340 LHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDP 399 I E R + ++ G +IPKD V L L DP Sbjct: 293 ------------AIEEALRVLSPSA-ALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDP 339 Query: 400 HYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSM 459 F P+ ++P F G CLG +AR E + + F + Sbjct: 340 RQFTDPEVYDPTR---------DPNPHFGFGRGIHFCLGAPLARLEGRVALNALFDRFPV 390 Query: 460 --ASPVAPEDIDLTPQECGVGKI 480 P P TP GV + Sbjct: 391 LRTDPAKPPTFFPTPDMIGVNTL 413 >3S79-A nrPDB Length = 503 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 78/449 (17%), Positives = 169/449 (37%), Gaps = 33/449 (7%) Query: 38 PLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSG 97 PL+ + + G+ + + YG+ V + +++ ++ + + Sbjct: 58 PLISHG-RFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRF 116 Query: 98 RGKIAMVDPFFRGYGVIFAN-GNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEE 156 K+ + G+IF N WK R F + + G G + E + ++ Sbjct: 117 GSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALS--GPGLVRMVTVCAESLKTHLDR 174 Query: 157 LRK--SKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFG 214 L + ++ +D L + + + ++ R + + + ++ + Sbjct: 175 LEEVTNESGYVDVLTLLRRVMLDTSNTLFL--RIPLDESAIVVKIQGYFDAW-------- 224 Query: 215 QLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEK 274 Q + +++ K+++++ I + + R + + + + Sbjct: 225 QALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELIL 284 Query: 275 EKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP 334 + + + +N+N L + A +T S +L + L+ K+P+V E + +EI+ VIG Sbjct: 285 AEKR--GDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG- 341 Query: 335 HRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILST 394 R ++ D K+ E IYE R+ ++ + V + GY + K T + L + Sbjct: 342 ERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGR 400 Query: 395 ALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTIL 454 +F KP+ F ++F F PF G R C G+ IA + T+L Sbjct: 401 MHR-LEFFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLL 455 Query: 455 QNFSMASPVA--------PEDIDLTPQEC 475 + F + + D+ L P E Sbjct: 456 RRFHVKTLQGQCVESIQKIHDLSLHPDET 484 >4ZGX-A nrPDB Length = 489 Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats. Identities = 69/392 (17%), Positives = 138/392 (35%), Gaps = 21/392 (5%) Query: 60 EKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGR----GKIAMVDPFFRGYGVIF 115 ++ G +F +LG +V + E + + L R +A GV Sbjct: 50 QELGPIFRYNLGGPRMVCVMLPEDVEK-LQQVDSLHPCRMILEPWVAYRQHRGHKCGVFL 108 Query: 116 ANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRK-----SKGAL-MDPTF 169 NG W+ R + + + A+ + L+K ++G+L +D Sbjct: 109 LNGPEWRFNR-LRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQP 167 Query: 170 LFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYF-P 228 T +FG+R F ++ QL + ++ P Sbjct: 168 SIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISP 227 Query: 229 GAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNL 288 ++ ++ I Y + ++K + L + P+ + +E S + + Sbjct: 228 KVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIV------AELLLKAELSLEAI 281 Query: 289 NLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPY 348 N++ L +TT+ L + + P V + + +E ++P Sbjct: 282 KANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPL 341 Query: 349 TEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAF 408 A + E R + + + +V+ + Y IP T V + L + + F +P+ + Sbjct: 342 LRAALKETLRLYP-VGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERY 400 Query: 409 NPDHFLDANGALKKTEAFIPFSLGKRICLGEG 440 NP +LD G+ + +PF G R CLG Sbjct: 401 NPQRWLDIRGSGRN-FHHVPFGFGMRQCLGRR 431 >5IT1-A nrPDB Length = 399 Score = 181 bits (458), Expect = 8e-46, Method: Composition-based stats. Identities = 66/422 (15%), Positives = 139/422 (32%), Gaps = 73/422 (17%) Query: 72 PRPVVMLCGVEAIREALVDKAEAFSGRGKIAMV--DPFFRGYG---VIFANGNRWKVLRR 126 ++ G E +R A++ G + G +++ + R+ Sbjct: 42 GHEAWLVTGYEQVR-AVLRDPSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEHTDDRK 100 Query: 127 FSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFG 185 ++F + + +++ IQ ++ + +++G +D F + +++ S +FG Sbjct: 101 LL---AKEFTVRRMQALRPNIQRIVDEHLDAI-EARGGPVDLVKTFANPVPSMVISDLFG 156 Query: 186 KRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYI 245 + EF ++ + + + Sbjct: 157 VPAERRA-EFQEIAEAMMR----------------------VDQDAAATEAAGMRLGGLL 193 Query: 246 GHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTST 305 V++ R P D + + L+ E + L +L A +TT+ Sbjct: 194 YQLVQERRA-----NPGDDLISALITTE----DPDGVIDDMFLMNAAGTLLIAAHDTTAC 244 Query: 306 TLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPM 365 + G L+L P + ++ + E+ R+ + Sbjct: 245 MIGLGTALLLDRPDQLALLQKD------------------PSLIGNAVEELLRYLTIGQF 286 Query: 366 GVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEA 425 G + TQ G I K +V L +A DP + E P+ F+ + Sbjct: 287 GAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITR---------RPAP 337 Query: 426 FIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAP-EDIDLTPQE--CGVGKIPP 482 + F G C+G+ +AR EL + F T+ + F P E++ GV ++P Sbjct: 338 HLAFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKPVEELRFRNDMVFYGVHELPV 397 Query: 483 TY 484 T+ Sbjct: 398 TW 399 >1Z8P-A nrPDB Length = 404 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 70/440 (15%), Positives = 134/440 (30%), Gaps = 82/440 (18%) Query: 64 DVFTVHLGPRPVVMLCGVEAIREALVDK-------------AEAFSGRGKIAMVDPFFRG 110 V V + ++ G + + AL D F + Sbjct: 28 PVTPVRFLGQDAWLVTGYDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVRNYFA 87 Query: 111 YGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRKSKGALMDPTF 169 + ++ LR+ +F + + ++ R+++ L++E ++D Sbjct: 88 TNMGTSDPPTHTRLRKLVSQ---EFTVRRVEAMRPRVEQITAELLDE--VGDSGVVDIVD 142 Query: 170 LFQS-ITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFP 228 F + +IC E L + + F SS L P Sbjct: 143 RFAHPLPIKVIC-------------ELLGVDEKYRGEFGRWSS----------EILVMDP 179 Query: 229 GAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNL 288 Q + +E+ +I VE+ R + D L + + + + S L Sbjct: 180 ERAEQRGQAAREVVNFILDLVERRR--------TEPGDDLLSALIRVQDDDDGRLSADEL 231 Query: 289 NLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPY 348 L L AG E++ + + G L+L +P V R+ Sbjct: 232 TSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVRRDPSA------------------ 273 Query: 349 TEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAF 408 + EI R+ P + G IP+ + V + A DP F P F Sbjct: 274 LPNAVEEILRYIAP-PETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRF 332 Query: 409 NPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPED 467 + + T + F G C+G +A+ E + + F ++ + +D Sbjct: 333 D---------VTRDTRGHLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADD 383 Query: 468 IDLTPQEC--GVGKIPPTYQ 485 + G+ +P Sbjct: 384 VVWRRSLLLRGIDHLPVRLD 403 >6M7X-A nrPDB Length = 484 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 77/442 (17%), Positives = 151/442 (34%), Gaps = 32/442 (7%) Query: 20 VQRHPNTHDR-------LPPGPRPLPLLGNLLQM----DRRGLLKSFLRFREKYGDVFTV 68 + + ++ R +P P L LLQ+ L + ++ G +F Sbjct: 1 MAKKTSSVPRTVLPFEAMPRRPGNRWL--RLLQIWREQGYEDLHLEVHQTFQELGPIFRY 58 Query: 69 HLGPRPVVMLCGVEAIR---EALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLR 125 LG +V + E + + S +A GV NG W+ R Sbjct: 59 DLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNR 118 Query: 126 RFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRK-----SKGAL-MDPTFLFQSITANII 179 + + + A+ + L+K ++G+L +D T Sbjct: 119 -LRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEAS 177 Query: 180 CSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYF-PGAHRQVYKNL 238 +FG+R F ++ QL + ++ P ++ ++ Sbjct: 178 NLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAW 237 Query: 239 QEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFA 298 I Y + ++K + L S P+ + ++E S + N++ L Sbjct: 238 DCIFQYGDNCIQKIYQELAFSRPQQYTSIV------AELLLNAELSPDAIKANSMELTAG 291 Query: 299 GTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQR 358 +TT L + + P+V + + +E ++P A + E R Sbjct: 292 SVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLR 351 Query: 359 FSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANG 418 + + + + + + Y IP T V + L + +P F +P+ +NP +LD G Sbjct: 352 LYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG 410 Query: 419 ALKKTEAFIPFSLGKRICLGEG 440 + + +PF G R CLG Sbjct: 411 SGRN-FYHVPFGFGMRQCLGRR 431 >4WPZ-A nrPDB Length = 397 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 75/420 (17%), Positives = 134/420 (31%), Gaps = 75/420 (17%) Query: 77 MLCGVEAIREALVD-----KAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTT 131 M+ +R+ LVD K A + ++ + LR+ Sbjct: 41 MVTKHADVRKVLVDSRFSSKVMATAAAAMSETETGKLMNESLVGMDAPEHTRLRKLVTKA 100 Query: 132 MRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQ-SITANIICSIVFGKRFHY 190 ++ RI E L++EL +D F + +IC ++ Sbjct: 101 FT--ARRVETLRPRITELVGQLLDELETLP-RPVDLVKNFSVPLPVRVICELL---GVPA 154 Query: 191 QDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVE 250 DQ+ F +S L + + Y G + Sbjct: 155 GDQDT---------------------FHAWSNALLGDWQQVVEKEAATVSLVNYFGELIA 193 Query: 251 KHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYG 310 RE P D + + L+ + S+ S + + + ++ + AG ETT+ + Sbjct: 194 VKRE-----NPADDLISELIAI----SDGDSTLTEREIIALSIGILSAGHETTANQISMF 244 Query: 311 FLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMG--VP 368 + +L P +++ E + + E+ RF L G +P Sbjct: 245 LVTLLHNPEELDKLRDNREAI------------------PKAVDELLRFVPLTTTGGIIP 286 Query: 369 HIVTQHTSF-RGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFI 427 + T G ++P V ++TA DP FE + N ++ + Sbjct: 287 RLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLN---------VTRENNPHL 337 Query: 428 PFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPE-DIDLTPQEC--GVGKIPPTY 484 F G CLG +AR EL IL PE ++ L G+ +P T+ Sbjct: 338 AFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSASIIRGLESLPITW 397 >3A50-A nrPDB Length = 411 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 79/429 (18%), Positives = 133/429 (31%), Gaps = 74/429 (17%) Query: 64 DVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIA----MVDPFFRGYGVIFANGN 119 V + L PV +L +REA VD + R ++ P +I + Sbjct: 34 PVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQRADMPATPTPMMILMDPP 93 Query: 120 RWKVLRRFSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRKSKGALMDPTFLF-QSITAN 177 LR+ R F + + +E RI E A L+ L +D + I Sbjct: 94 DHTRLRKL---VGRSFTVRRMNELEPRITEIADGLLAGLPTD--GPVDLMREYAFQIPVQ 148 Query: 178 IICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKN 237 +IC E L + FS SSV Sbjct: 149 VIC-------------ELLGLPAEDRDDFSAWSSVLVD------------DSPADDKNAA 183 Query: 238 LQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFF 297 + +++ Y+ +E+ R D D L + S + L + L Sbjct: 184 MGKLHGYLSDLLERKRTEPD--------DALLSSLLAVSDMDGDRLSQEELVAMAMLLLI 235 Query: 298 AGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQ 357 AG ETT + G L +L +P + + + + + E Sbjct: 236 AGHETTVNLIGNGVLALLTHPDQRKLLAED------------------PSLISSAVEEFL 277 Query: 358 RFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDAN 417 RF + + ++ G IP V L L+ A D + +PD + Sbjct: 278 RFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGG 337 Query: 418 GALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTIL-QNFSMASPVAPEDIDLTPQEC- 475 + F G CLG +AR E + + +A V +++ Sbjct: 338 ---------VFFGHGIHFCLGAQLARLEGRVAIGRLFADRPELALAVGLDELVYRRSTLV 388 Query: 476 -GVGKIPPT 483 G+ ++P T Sbjct: 389 RGLSRMPVT 397 >4RM4-A nrPDB Length = 396 Score = 177 bits (449), Expect = 9e-45, Method: Composition-based stats. Identities = 68/352 (19%), Positives = 122/352 (34%), Gaps = 57/352 (16%) Query: 108 FRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDP 167 G +I + + +R M + E RIQE LI++ + D Sbjct: 76 SIGNSIINMDPPKHTKIRSVVNKAFTPRVM--KQWEPRIQEITDELIQKFQGRSE--FDL 131 Query: 168 TFLFQ-SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKY 226 F + +I ++ H ++F +L +S+ + E FL Sbjct: 132 VHDFSYPLPVIVISELLGVPSAHM--EQFKAWSDLL------VSTPKDKSEEAEKAFL-- 181 Query: 227 FPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQ 286 + K +E+ A+ +E+ R + P+ I + L+ E + S + Sbjct: 182 -----EERDKCEEELAAFFAGIIEEKR-----NKPEQDIISILVEAE----ETGEKLSGE 227 Query: 287 NLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKM 346 L L AG ETT+ + +L+ P V E + R+ Sbjct: 228 ELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEEL------------------RSHP 269 Query: 347 PYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPD 406 + E RF P+ + I + T G++I + V +++A D F++P Sbjct: 270 ELMPQAVEEALRFRAPAPV-LRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPH 328 Query: 407 AFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 458 F+ I F G CLG +AR E + T+++ F Sbjct: 329 MFDIRRH---------PNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFP 371 >3ABA-A nrPDB Length = 403 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 63/422 (14%), Positives = 137/422 (32%), Gaps = 73/422 (17%) Query: 72 PRPVVMLCGVEAIREALVDKAEAFSGRGKIAMV--DPFFRGYG---VIFANGNRWKVLRR 126 ++ G E +R AL+ + + G +++ + R+ Sbjct: 42 GHEAWLVTGYEEVR-ALLRDSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHTSDRK 100 Query: 127 FSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFG 185 ++F + + +++ IQ ++ + +++G +D F + +++ S +FG Sbjct: 101 LL---AKEFTVRRMQALRPNIQRIVDEHLDAI-EARGGPVDLVKTFANAVPSMVISDLFG 156 Query: 186 KRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYI 245 + + F+ + + + + Sbjct: 157 VPVERRAE-----------------------FQDIAEAMMRVDQDAAATEAAGMRLGGLL 193 Query: 246 GHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTST 305 V++ R P D + + L+ E + L +L A +TT+ Sbjct: 194 YQLVQERRA-----NPGDDLISALITTE----DPDGVVDDMFLMNAAGTLLIAAHDTTAC 244 Query: 306 TLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPM 365 + G L+L P + + + E+ R+ + Sbjct: 245 MIGLGTALLLDSPDQLALLRED------------------PSLVGNAVEELLRYLTIGQF 286 Query: 366 GVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEA 425 G + T+ G I K +V + A DP + E+P+ F+ + Sbjct: 287 GGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITR---------RPAP 337 Query: 426 FIPFSLGKRICLGEGIARAELFLFFTTILQNFS---MASPVAPEDIDLTPQECGVGKIPP 482 + F G C+G+ +AR EL + F T+ + +A PV GV ++P Sbjct: 338 HLAFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFRHDMVFYGVHELPV 397 Query: 483 TY 484 T+ Sbjct: 398 TW 399 >2WM5-A nrPDB Length = 435 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 82/470 (17%), Positives = 152/470 (32%), Gaps = 77/470 (16%) Query: 34 PRPLPL----LGNL--LQMDRRGLLKSFLRFREKYGDVF--TVHLGPRPVV----MLCGV 81 P +P+ LG+L +D +F R + F T+ L L Sbjct: 23 PPEVPIADIELGSLDFWALDDDVRDGAFATLRREAPISFWPTIELPGFVAGNGHWALTKY 82 Query: 82 EAIREALVDKAEAFSGRGKIAM--VDPFFRGY--GVIFANGNRWKVLRRFSVTTMRDFGM 137 + + A + FS I + P Y +I + R + LR + Sbjct: 83 DDVFYA-SRHPDIFSSYPNITINDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVV 141 Query: 138 GKRSVEERIQEEAQCLIEEL-RKSKGALMDPTFLF-QSITANIICSIVFGKRFHYQDQEF 195 + +E +++ A L+ + + D + IIC ++ + +Q Sbjct: 142 AR--IEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQ---- 195 Query: 196 LKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRET 255 +F+ T ++ L F F+ + +I AY E R Sbjct: 196 ----RIFHWTNVILGFGDPDLATDFDEFM-----------QVSADIGAYATALAEDRRV- 239 Query: 256 LDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315 + DL + + E S + + + L AG ETT + +G L + Sbjct: 240 ---NHHDDLTSSLV-----EAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALS 291 Query: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375 +YP +R + + + + EI R++ + + + +TQ Sbjct: 292 RYPEQRDRWWSDFDG-----------------LAPTAVEEIVRWASPV-VYMRRTLTQDI 333 Query: 376 SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPF-SLGKR 434 RG + +V L +A D F P F+ + F G Sbjct: 334 ELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLAR---------NPNPHLGFGGGGAH 384 Query: 435 ICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTY 484 CLG +AR E+ + F + + L+ G+ +P T+ Sbjct: 385 FCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTW 434 >6GK6-A nrPDB Length = 411 Score = 175 bits (444), Expect = 4e-44, Method: Composition-based stats. Identities = 85/427 (19%), Positives = 136/427 (31%), Gaps = 92/427 (21%) Query: 75 VVMLCGVEAIREALVDKAEAFSGRGKIAMVDPF-FRGYGVIFANGNRWKVLRRFSVTTMR 133 V +L IR+ K R + D F ++ A+ LR Sbjct: 54 VELLKDPRLIRDF--RKLPDEVRRRYFPLSDRTTFMDQHMLDADPPDHTRLRAIVQRAFS 111 Query: 134 DFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQ 193 M + RIQE A LI+ + D+ Sbjct: 112 PRMM--EGLRPRIQEIADGLIDAV---------------------------------IDR 136 Query: 194 EFLKMLNLFYQTFSLISSVFGQLFEL-------FSGFLKYF--PGAHRQVYKNLQ----E 240 ++++ F F L ++V +L L F + K P R+ + Q E Sbjct: 137 RRMELIADF--AFPLPTAVIAELLGLPVEDRGRFRRWTKILLAPAKDREFVERAQPVVEE 194 Query: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300 AY + R+ AP+D + + LL E+++ S L+ L AG Sbjct: 195 FAAYFRALADARRK-----APRDDLISGLLLAEEQEHK----LSPAELSSMVFLLLVAGH 245 Query: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360 ETT + G LL+L +P R+ + + + E R Sbjct: 246 ETTVHLIASGMLLLLSHPAERRRLDEDPG------------------LVGSAVEEALRCE 287 Query: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420 + + G +P V L A DP +F PD F+ Sbjct: 288 GPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGR-------- 339 Query: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPEDIDLT--PQECGV 477 I F G CLG +AR E + F+T+L+ + + DI + P G Sbjct: 340 -SPNRHIGFGGGIHFCLGAMLARIEAAIAFSTLLRRLPRIELATSTRDIVWSEWPTIRGP 398 Query: 478 GKIPPTY 484 +P + Sbjct: 399 AAVPVVF 405 >3ABB-A nrPDB Length = 408 Score = 175 bits (444), Expect = 4e-44, Method: Composition-based stats. Identities = 73/422 (17%), Positives = 144/422 (34%), Gaps = 73/422 (17%) Query: 72 PRPVVMLCGVEAIREALVD-KAEAFSGRGKIAMVDPFFRGYG-----VIFANGNRWKVLR 125 RP ++ G R LVD + + G +V G +I + R Sbjct: 47 GRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGLAFPLIGVDDPVHARQR 106 Query: 126 RFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFG 185 R + + M ++ R+Q L++++ +KG D F ++ + G Sbjct: 107 RMLIPSFGVKRM--NAIRPRLQSLVDRLLDDML-AKGPGADLVSAFALPVPSVAICELLG 163 Query: 186 KRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYI 245 Y D +F + + + + + E+ Y+ Sbjct: 164 --VPYGDHDFFEECSRNFVGAATSAEADA----------------------AFGELYTYL 199 Query: 246 GHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTST 305 V + + P+D + L+ + E+ + H + + L L AG ETT Sbjct: 200 HGLVGRKQA-----EPEDGLLDELIARQLEEGD----LDHDEVVMIALVLLVAGHETTVN 250 Query: 306 TLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPM 365 + G L ++++P + + R+ V G V+ E+ RF+ + Sbjct: 251 AIALGALTLIQHPEQIDVLLRDPGAVSG------------------VVEELLRFTSVSDH 292 Query: 366 GVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEA 425 V + + G I V + ++ D +E PD F+ A + Sbjct: 293 IV-RMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFD---------ARRNARH 342 Query: 426 FIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPEDIDLTP--QECGVGKIPP 482 + F G CLG+ +ARAEL + + + V +++ + G ++P Sbjct: 343 HVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLAVPLDEVPIKAGHDAQGPIELPV 402 Query: 483 TY 484 + Sbjct: 403 VW 404 >5FOI-A nrPDB Length = 408 Score = 175 bits (443), Expect = 4e-44, Method: Composition-based stats. Identities = 68/419 (16%), Positives = 139/419 (33%), Gaps = 71/419 (16%) Query: 72 PRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYG---VIFANGNRWKVLRRFS 128 P ++ E +R LVD + + + G G ++ + LRR Sbjct: 55 GSPTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMF 114 Query: 129 VTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRF 188 ++ + ++ I++ +++ L + + T L ++ +IC ++ Sbjct: 115 ISAFSVRQV--ETMRPEIEKIVDGILDRLLALEPPVDILTHLALPMSTQVICHLL---GV 169 Query: 189 HYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHS 248 Y+D+EF + + P R + L E+ Y+ Sbjct: 170 PYEDREFFQERSELASR----------------------PNDDRSM-PALIELVEYLDGL 206 Query: 249 VEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLR 308 V DT LL + E +HQ L N + L AG ET++ + Sbjct: 207 VRTKTAHP---------DTGLLGTAVTERLLKGEITHQELVNNAVLLLAAGHETSANQVT 257 Query: 309 YGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVP 368 L +L++P A + + E + E+ R+ + G+ Sbjct: 258 LSVLTLLRHPETAAELREQPE------------------LMPNAVDELLRYHSIAD-GLR 298 Query: 369 HIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIP 428 T + I + ++LS+A HD + F F+ + Sbjct: 299 RAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHR---------PARHHVA 349 Query: 429 FSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPEDIDLTPQE--CGVGKIPPTY 484 F G CLG+ +AR E+ + + + + P+ + + G+ ++ + Sbjct: 350 FGYGPHQCLGQNLARLEMEVTLGKLFRRVPALRLAQEPDALRVRQGSPIFGIDELLVEW 408 >5LIE-A nrPDB Length = 414 Score = 175 bits (443), Expect = 5e-44, Method: Composition-based stats. Identities = 68/376 (18%), Positives = 123/376 (32%), Gaps = 57/376 (15%) Query: 103 MVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKG 162 + D G + + R +RR + + R VE+ ++ A+ L++ G Sbjct: 85 LQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTP--RMIRRVEDDLRRRARGLLD--GVEPG 140 Query: 163 ALMD-PTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFS 221 A D + + +IC ++ + + + F S Sbjct: 141 APFDFVVEIAAELPMQMICILL-----GVPETDRHWLFEAVEPGFDFRGS---------- 185 Query: 222 GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHS 281 + V + Y + R P D + + + + + +A + Sbjct: 186 ---RRATMPRLNVEDAGSRLYTYALELIAGKRA-----EPADDMLSVVANATIDDPDAPA 237 Query: 282 EFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELH 341 S L L LF AG ETT ++ G L + + P + + + E Sbjct: 238 -LSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFE------------ 284 Query: 342 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 401 I EI R++ P ++ S G I +V + +A DP Sbjct: 285 ------LLPTAIEEIVRWTSPSP-SKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSV 337 Query: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 461 F++ D F+ K + F G CLG +AR EL + F +L F Sbjct: 338 FDRADEFDITR---------KPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVR 388 Query: 462 PVAPEDIDLTPQECGV 477 V P + + + G+ Sbjct: 389 VVEPAEWTRSNRHTGI 404 >6B11-A nrPDB Length = 440 Score = 174 bits (442), Expect = 5e-44, Method: Composition-based stats. Identities = 69/421 (16%), Positives = 145/421 (34%), Gaps = 74/421 (17%) Query: 72 PRPVVMLCGVEAIREALVD-KAEAFSGR-GKIAMVDPFFRG-YGVIFANGNRWKVLRRFS 128 PV ++ + +R L D + + +++ D ++ + LR Sbjct: 86 GAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDGEAEASRSLLTLDPPDHGALR--- 142 Query: 129 VTTMRDFGMGK-RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQ-SITANIICSIVFGK 186 + +FG+ + R + +++ L+++L ++G D F + +IC ++ Sbjct: 143 GHFIPEFGLRRVRELRPSVEQIVTGLLDDLT-ARGDEADLLADFALPMATQVICRLL--- 198 Query: 187 RFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIG 246 Y+D+++ F + + P A + + L E+ Y+ Sbjct: 199 DIPYEDRDY------FQERTEQATR----------------PAAGEEALEALLELRDYLD 236 Query: 247 HSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTT 306 + ++ D L M + SH ++ N + L AG ETT++ Sbjct: 237 RLI-------SGKTGRESGDGMLGSMVAQAR--GGGLSHADVLDNAVLLLAAGHETTASM 287 Query: 307 LRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMG 366 + L++L++P + + E+ R+ + G Sbjct: 288 VTMSVLVLLQHPTAWREL------------------TVNPGLLPGAVDELLRYLSIAD-G 328 Query: 367 VPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAF 426 + T G+ I + +L+ A D F +P+AF+ Sbjct: 329 LRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHR---------SARRH 379 Query: 427 IPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP-VAPEDIDLTPQEC--GVGKIPPT 483 + F G CLG+ +AR EL + +L+ P + L GV ++P Sbjct: 380 VAFGYGPHQCLGQNLARMELEVALGAVLERLPALRPTTDVAGLRLKSDSAVFGVYELPVA 439 Query: 484 Y 484 + Sbjct: 440 W 440 >1LG9-A nrPDB Length = 398 Score = 174 bits (441), Expect = 8e-44, Method: Composition-based stats. Identities = 66/422 (15%), Positives = 137/422 (32%), Gaps = 85/422 (20%) Query: 79 CGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVI-----------FANGNRWKVLRRF 127 +R+ + D + FS R + D G G+ + ++ R+ Sbjct: 46 TAHAVVRQVMGDHQQ-FSTRRRWDPRDEI-GGKGIFRPRELVGNLMDYDPPEHTRLRRKL 103 Query: 128 SVTTMRDFGMGK-RSVEERIQEEAQCLIEELRKSKGALMD-PTFLFQSITANIICSIVFG 185 + F + K + + I++ ++E+ ++ G+ D F+ + ++C +V Sbjct: 104 T----PGFTLRKMQRMAPYIEQIVNDRLDEMERA-GSPADLIAFVADKVPGAVLCELV-- 156 Query: 186 KRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYI 245 D++ + G L S Q+ A + Sbjct: 157 -GVPRDDRDM------------FMKLCHGHLDASLS-----------------QKRRAAL 186 Query: 246 GHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTST 305 G ++ + K+ + + + E + + + L + + AG + S Sbjct: 187 GDKFSRYLLAMIARERKEPGEGMIGAVVAEYGDDA---TDEELRGFCVQVMLAGDDNISG 243 Query: 306 TLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPM 365 + G L ML++P + + + + + E+ R+ + Sbjct: 244 MIGLGVLAMLRHPEQIDAFRGDEQS------------------AQRAVDELIRYLTVPYS 285 Query: 366 GVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEA 425 P I + + G I K V L A DP D + ++ Sbjct: 286 PTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLD---------VTREPIP 336 Query: 426 FIPFSLGKRICLGEGIARAELFLFFTTILQNFS---MASPVAPEDIDLTPQECGVGKIPP 482 + F G CLG +AR EL FT + + F +A P + LT G+ ++ Sbjct: 337 HVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQDTEFRLTTPAYGLTELMV 396 Query: 483 TY 484 + Sbjct: 397 AW 398 >6M7L-A nrPDB Length = 404 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 81/448 (18%), Positives = 146/448 (32%), Gaps = 77/448 (17%) Query: 43 LLQMDRRGLLKSFLRFREKYGDVFTVHL--GPRPVVMLCGVEAIREALVDKAEAFSGRGK 100 +L + R L + L+ + G + + L G G + +RE L + G Sbjct: 28 VLHLRDRLDLAAELKLLCERGPLVRIPLEDGSAVHWFALGYDVVREVLGSEKFDKRVIGT 87 Query: 101 IAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKS 160 ++ + LRR M +++E R+Q ++ + + Sbjct: 88 HFNHQEMALPGNLLQLDPPEHTRLRRMVAPAYSVRRM--QALEPRVQAIVDDHLDTMAST 145 Query: 161 KGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELF 220 + + + A + C EFL + +++ G Sbjct: 146 GPPVEFLREVAGPMAARVAC-------------EFLGIPLDDRGELIRLTAHRG------ 186 Query: 221 SGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAH 280 G R+V + AY+ + R +D D L + ++ Sbjct: 187 --------GKRRRVLNGHAYL-AYMRELAARLR--------RDPGDGMLGMVARDH---G 226 Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 ++ S + L + + E T + L G LL+L++P + Sbjct: 227 ADISDEELAGLCAVVMNSSVEQTESCLAAGTLLLLEHPEQFALLRE-------------- 272 Query: 341 HDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPH 400 + E + EI R+ + P T+ G +I K VF L A Sbjct: 273 ----RPELGEQAVEEIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANR--- 325 Query: 401 YFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-M 459 D LD +K + F G CLG +AR EL + FTT++ F + Sbjct: 326 ---------ADPALDGFDITRKESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRFPSL 376 Query: 460 ASPVAPEDIDLTPQECGV---GKIPPTY 484 + V E+I P V ++P T+ Sbjct: 377 RTAVPAEEIRFRPPSSNVFTLLELPLTW 404 >5OFQ-A nrPDB Length = 409 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 77/415 (18%), Positives = 139/415 (33%), Gaps = 70/415 (16%) Query: 78 LCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGM 137 + E ++ L FS + + ++ + + LR + Sbjct: 54 VFDYETVKYIL-KNPSLFSSKRAMEERQ-----ESILMMDPPKHTKLRNLVNKAFTPRAI 107 Query: 138 GKRSVEERIQEEAQCLIEELRKSKGALMDPTFLF-QSITANIICSIVFGKRFHYQDQEFL 196 + +E I+E A L++E S D F + +I ++ QD+ Sbjct: 108 --QHLEGHIEEIADYLLDE--VSSKEKFDIVEDFAGPLPIIVIAELL---GVPIQDRALF 160 Query: 197 KMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL 256 K + L+S E F+ ++ + + + + Y + + ++ Sbjct: 161 KKYSD-----DLVSGAENNSDEAFAKMMQ-------KRNEGVIFLQGYFKEIIAERQQ-- 206 Query: 257 DPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLK 316 + +DLI L E + + + + L AG ETT+ + G M + Sbjct: 207 --NKQEDLISLLL-----EAEIDGEHLTEEEVLGFCILLLVAGNETTTNLITNGVRYMTE 259 Query: 317 YPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTS 376 V V R+I ++ E R+ + + I + Sbjct: 260 DVDVQNEVRRDI------------------SLVPNLVEETLRYYPPIQ-AIGRIAAEDVE 300 Query: 377 FRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRIC 436 I + +V ++A D FE PD F KT + F G C Sbjct: 301 LGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR---------KTNPHVSFGFGIHFC 351 Query: 437 LGEGIARAELFLFFTTILQN--FSMASPVAPEDIDLTPQECGVGKIPPTYQIRFL 489 LG +AR E + FT +L+ FS + + ID +P GV K Y+I F Sbjct: 352 LGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPID-SPFVFGVKK----YEIAFN 401 >4Z5P-A nrPDB Length = 400 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 68/393 (17%), Positives = 120/393 (30%), Gaps = 67/393 (17%) Query: 97 GRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEE 156 G R ++ + LRR MG +++ ++E L++ Sbjct: 70 GEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSKAFTARRMG--AMQSWLEELFAGLLDG 127 Query: 157 LRKSKGALMDP-TFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQ 215 + ++ G D L Q T +IC ++ Y+D+ F S V Sbjct: 128 VERT-GHPADIVRDLAQPFTIAVICRLL---GVPYEDR----------GRFQHWSEV--- 170 Query: 216 LFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKE 275 + + + I AY+ V R AP D + L+ Sbjct: 171 -------IMSTTAYSKEEAVSADASIRAYLADLVSARRA-----APHDDLLGVLVSAR-- 216 Query: 276 KSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPH 335 + + L ++L AG ET++ L +L + + + E Sbjct: 217 --DDDDRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPE------ 268 Query: 336 RPPELHDRAKMPYTEAVIYEIQRFSDL-LPMGVPHIVTQHTSFRGYIIPKDTEVFLILST 394 + E+ RF L +G I + G + V Sbjct: 269 ------------LLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVN 316 Query: 395 ALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTIL 454 A DP F+ PD + + + F G CLG +AR EL + +L Sbjct: 317 ANRDPRAFDDPDRLDITR---------EKNPHLAFGHGAHYCLGAQLARMELRVAIGGLL 367 Query: 455 QNFS---MASPVAPEDIDLTPQECGVGKIPPTY 484 + F +A P + G ++P + Sbjct: 368 ERFPGLRLAVPADQVEWKTGGLFRGPQRLPIAW 400 >5NWS-A nrPDB Length = 435 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 56/362 (15%), Positives = 118/362 (32%), Gaps = 63/362 (17%) Query: 112 GVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEEL--RKSKGALMDPTF 169 ++ ++ LRR + + I+ A L+ EL R+ + +D Sbjct: 114 SILDSDPPDHPRLRRLVTRAFAARRIL--GLRPGIERIADRLLAELPRREEEDGTVDLLE 171 Query: 170 LFQ-SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFP 228 F ++ +IC E + + + + G L + L++ Sbjct: 172 HFAYPLSITVIC-------------ELVGIPATDLERWREWG---GDLVSMRPERLRH-- 213 Query: 229 GAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNL 288 + + Y +E+ R L D L + + + + S Sbjct: 214 --------SFPVMIDYCHRLIEQRRAA--------LTDDLLSELIRAQDDDGGRLSDIET 257 Query: 289 NLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPY 348 L+L AG ET++ + G +L +P + ++ Sbjct: 258 VTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALLRKD------------------PAL 299 Query: 349 TEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAF 408 ++E+ R+ + + T+ G + + V L+L +A DP ++ PD Sbjct: 300 LPRAVHELMRWCGSVHVARLRYATEDLELAGTPVARGDAVQLVLVSANFDPRHYSDPDRL 359 Query: 409 NPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF-SMASPVAPED 467 + + E + F G CLG +AR E + +L+ + +A + Sbjct: 360 DITRHQEGQ-----AENHVGFGHGIHYCLGATLARQEGEVALARLLETYPDLALADGDPE 414 Query: 468 ID 469 + Sbjct: 415 VR 416 >6FSH-A nrPDB Length = 398 Score = 171 bits (432), Expect = 9e-43, Method: Composition-based stats. Identities = 63/419 (15%), Positives = 125/419 (29%), Gaps = 81/419 (19%) Query: 80 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFA----------NGNRWKVLRRFSV 129 G +R+ L D + FS R + D G G+ + LR Sbjct: 47 GHAVVRQVLGDHQQ-FSTRRRWDPRDEI-GGKGIFRPRELVGNLMDYDPPEHTRLRHLLT 104 Query: 130 TTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQ-SITANIICSIVFGKRF 188 M R + RI+E ++ + + G D LF + ++C ++ Sbjct: 105 PGFTQRRM--RRLAPRIEEIVTDRLDAM-EQAGPPADLIELFADEVPGAVLCELI---GV 158 Query: 189 HYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHS 248 D++ + G L S Q+ A +G Sbjct: 159 PRDDRDM------------FMKLCHGHLDASLS-----------------QKRRAALGDK 189 Query: 249 VEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLR 308 ++ + KD D ++ + E + + + L + L AG + S + Sbjct: 190 FSRYLLAMIARERKDPGDGFIGSIVAEHGDT---ITDEELRGVCVQLMLAGDDNVSGMIG 246 Query: 309 YGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVP 368 G L +L++P + + + + + E+ R+ + P Sbjct: 247 LGVLALLRHPEQIAALRGDDQS------------------ADRAVDELIRYLTVPYAPTP 288 Query: 369 HIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIP 428 + +I + V L A D D + + + Sbjct: 289 RTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLD---------VTRTPVPHVA 339 Query: 429 FSLGKRICLGEGIARAELFLFFTTILQNFS---MASPVAPEDIDLTPQECGVGKIPPTY 484 F G CLG + R +L + +T + + F +A P + G+ + + Sbjct: 340 FGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMFRTSTPAYGLTSLLVAW 398 >3WVS-A nrPDB Length = 401 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 62/378 (16%), Positives = 118/378 (31%), Gaps = 64/378 (16%) Query: 109 RGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPT 168 + + + LRR + + ++ + A LI+++ +KG D Sbjct: 86 QAKSMFNMDAPDHTRLRRLISKAFTIRRV--EELRPKVHDLAHRLIDDML-AKGEPADLV 142 Query: 169 FLFQ-SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYF 227 + I +IC ++ ++D+E + S ++ G++ + Sbjct: 143 ADYALPIPTTVICELL---GVPFEDREKFGRWTDAILSTSTLNPEEGRVKRM-------- 191 Query: 228 PGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQN 287 E+ YIG + R P D + + ++ + + Q Sbjct: 192 ------------ELVGYIGGIIAARRA-----QPADDLISGMIEARDVQDK----LTEQE 230 Query: 288 LNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMP 347 L + + L AG ETT++ + +L P +R+ + E Sbjct: 231 LLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWKRLLDDPE------------------ 272 Query: 348 YTEAVIYEIQRFSDL-LPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPD 406 + + E+ RF L P + G ++ V + L A D FE P+ Sbjct: 273 LIPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPE 332 Query: 407 AFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPE 466 D + I F G CLG +AR EL +L+ Sbjct: 333 EIKLDR---------PSNHHIGFGHGIHHCLGAPLARLELQEALRALLERLPTLKVAGDI 383 Query: 467 DIDLTPQECGVGKIPPTY 484 G +P + Sbjct: 384 AWKSEMMVRGPRSMPVGW 401 >6F0B-A nrPDB Length = 395 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 72/423 (17%), Positives = 140/423 (33%), Gaps = 74/423 (17%) Query: 72 PRPVVMLCGVEAIREALVDKA-EAFSGRGKIAMVDPFFRGYG-----VIFANGNRWKVLR 125 P + G E +R L D+ + S R + P + V N R Sbjct: 37 GTPAHVFSGYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNP----DHR 92 Query: 126 RFSVTTMRDF-GMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVF 184 R T R+F + I+E Q +++ L ++ P + ++ + + VF Sbjct: 93 RLRGTIAREFLPKHIELLRPAIREIVQGVLDGLAETAP----PQDMLEAFAVPVASATVF 148 Query: 185 GKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAY 244 ++L + + +L++ + G+ + + + + Y Sbjct: 149 ------------RLLGIPAEDRALLTRCVKGVVSAV--------GSEDEGAEVFRTLGEY 188 Query: 245 IGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTS 304 IG V+ P +L + L+ + + L L G +TT+ Sbjct: 189 IGGLVQD---------PSELPEDSLIRRLVTGPYQEKQLTFHETIGVILMLIVGGYDTTA 239 Query: 305 TTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLP 364 +T+ + P V+ E++ P + E+ R+ + Sbjct: 240 STISLSLVSYALQPEKFSVVHEHPERI---------------PLL---VEELLRYHTVSQ 281 Query: 365 MGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTE 424 +G+ I T+ G + V L A D F PD + D + Sbjct: 282 LGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR---------PSV 332 Query: 425 AFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPEDIDLTPQ--ECGVGKIP 481 + F G C+G+ +AR EL +++ M A ED+ G+ ++P Sbjct: 333 PHVGFGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLACALEDLPFRHDMATYGIHELP 392 Query: 482 PTY 484 T+ Sbjct: 393 MTW 395 >5YSW-A nrPDB Length = 441 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 72/440 (16%), Positives = 140/440 (31%), Gaps = 79/440 (17%) Query: 63 GDVFTVHLG-PRPVVMLCGVEAIREALVD---KAEAFSGRGKIAMVDPFFR--------- 109 G V L P ++ G E R L D ++ F + P FR Sbjct: 64 GPVARATLAAGDPFWLVSGYEEARAVLSDPRFSSDRFQYHPWFKELSPEFRERLRDDKAR 123 Query: 110 GYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTF 169 I + R+ + R + RI E ++ + T Sbjct: 124 AGSFINMDPPEHTRYRKLLTGQFTVRRI--RELGARIDEIVAGRVDAMLAGGTTADLMTE 181 Query: 170 LFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPG 229 + +IC ++ G R+ + EF + + Q + ++ Sbjct: 182 FAFPAPSLMICELL-GVRYEDRA-EFQQRASALLQMNAPVA------------------- 220 Query: 230 AHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLN 289 + KN + A++ V R + D+I + H + + + L Sbjct: 221 ---EAVKNADALRAFMQALVTDKRA----NPAGDIISGLIHHAGADPA-----LTDDELI 268 Query: 290 LNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYT 349 L AG +TT++ L G ++L+ P + + ++ Sbjct: 269 NIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPSRIAD---------------- 312 Query: 350 EAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFN 409 + E+ R+ ++ G+ + F G IP + V + + D ++ PD Sbjct: 313 --AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDPDL-- 368 Query: 410 PDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPEDI 468 + + F G CLG+ +AR E+ + +L+ + V PE++ Sbjct: 369 --------DLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPPEEV 420 Query: 469 DLTPQ--ECGVGKIPPTYQI 486 L GV +P + Sbjct: 421 PLRNDMLTYGVHSLPIAWDA 440 >1EHE-A nrPDB Length = 403 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 62/373 (16%), Positives = 118/373 (31%), Gaps = 64/373 (17%) Query: 117 NGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRK--SKGALMDPTFLFQSI 174 + R T + ++++ IQ L+E++++ +D F Sbjct: 90 DPPEHMHQRSMVEPTFTPEAV--KNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALP 147 Query: 175 TANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQV 234 + I + G + D E+L N S R+ Sbjct: 148 VPSYIIYTLLG--VPFNDLEYLTQQNAIRTNGS---------------------STAREA 184 Query: 235 YKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLS 294 QE+ Y+ VE+ PKD I + L + + N + Sbjct: 185 SAANQELLDYLAILVEQRLV-----EPKDDIISKLCTEQVKPGN----IDKSDAVQIAFL 235 Query: 295 LFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIY 354 L AG T + G + ++P ++ A + Sbjct: 236 LLVAGNATMVNMIALGVATLAQHPDQLAQLK------------------ANPSLAPQFVE 277 Query: 355 EIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFL 414 E+ R+ + + + ++ + + +A D FE PD FN + Sbjct: 278 ELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKW 337 Query: 415 DANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF-SMASPVAPEDIDLTP- 472 + + F G C+ E +A+AEL F+T+ Q F + V I+ TP Sbjct: 338 -------PPQDPLGFGFGDHRCIAEHLAKAELTTVFSTLYQKFPDLKVAVPLGKINYTPL 390 Query: 473 -QECGVGKIPPTY 484 ++ G+ +P + Sbjct: 391 NRDVGIVDLPVIF 403 >3NC3-A nrPDB Length = 441 Score = 169 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 80/414 (19%), Positives = 141/414 (34%), Gaps = 55/414 (13%) Query: 47 DRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDP 106 + F + RE+ V + + +R L + F+ + + +P Sbjct: 51 FQNNPYAYFSQLREE-DPVH--YEESIDSYFISRYHDVRYIL-QHPDIFTTKSLVERAEP 106 Query: 107 FFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLI-EELRKSKGALM 165 RG + +G RR V + G + I++ A+ L+ L + K L+ Sbjct: 107 VMRGPVLAQMHGKEHSAKRRIVVRSF--IGDALDHLSPLIKQNAENLLAPYLERGKSDLV 164 Query: 166 DPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLK 225 + + + KR H + E+ + F + S Sbjct: 165 NDFGKTF-AVCVTMDMLGLDKRDHEKISEWHSGVADFITSISQS---------------- 207 Query: 226 YFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSH 285 P A ++++ Y+ +++ R P + + L E E S Sbjct: 208 --PEARAHSLWCSEQLSQYLMPVIKERRV-----NPGSDLISILCTSEYE----GMALSD 256 Query: 286 QNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAK 345 +++ L++ A TE TL +L P V L DR+ Sbjct: 257 KDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDV---------------LADRSL 301 Query: 346 MPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKP 405 +P I E R+ + + +P ++Q T G I KDT VF ++ A DP FE+P Sbjct: 302 VP---RAIAETLRYKPPVQL-IPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQP 357 Query: 406 DAFNPDH-FLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 458 D FN L A + F G C+G A+ E+ + +L Sbjct: 358 DVFNIHREDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKMR 411 >4TX3-A nrPDB Length = 404 Score = 168 bits (426), Expect = 5e-42, Method: Composition-based stats. Identities = 62/416 (14%), Positives = 122/416 (29%), Gaps = 75/416 (18%) Query: 80 GVEAIREALVDKAEA-----FSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRD 134 G +R+ L D F R +I F V R Sbjct: 53 GHAVVRQVLGDHKRFSTRRRFDRRDEIGGTGVFRPRELVGNLMDYDPPEHTRLRHLLTPG 112 Query: 135 FGMGK-RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQ-SITANIICSIVFGKRFHYQD 192 F + R + RI+E ++ + + G D LF + ++C ++ R Sbjct: 113 FTQRRMRRLAPRIEEIVTDRLDAM-EQAGPPADLIELFADEVPGAVLCELIGVPR--DDQ 169 Query: 193 QEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL-QEINAYIGHSVEK 251 FL++ HR + +L A G + + Sbjct: 170 AMFLQL-------------------------------CHRHLDASLSARKRAAAGEAFAR 198 Query: 252 HRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGF 311 + + KD D ++ + E + + + L + L AG + S + G Sbjct: 199 YLVAMMARERKDPGDGFIGSIVAEHGDT---ITDEELRGVCVQLMLAGDDNVSGMIGLGV 255 Query: 312 LLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIV 371 L +L++P + + + + + E+ R+ + P Sbjct: 256 LALLRHPEQIAALRGDDQS------------------ADRAVDELIRYLTVPYAPTPRTA 297 Query: 372 TQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSL 431 + +I + V L A D D + + + F Sbjct: 298 VEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLD---------VTRTPVPHVAFGH 348 Query: 432 GKRICLGEGIARAELFLFFTTILQNFS---MASPVAPEDIDLTPQECGVGKIPPTY 484 G CLG + R +L + +T + + F +A P + G+ + + Sbjct: 349 GIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMFRTSTPAYGLTSLLVAW 404 >4JBT-A nrPDB Length = 410 Score = 168 bits (425), Expect = 5e-42, Method: Composition-based stats. Identities = 65/421 (15%), Positives = 138/421 (32%), Gaps = 78/421 (18%) Query: 63 GDVFTVHLGPRPVVMLCGVEAIREALVDK-----------AEAFSGRGKIAMVDPFFRGY 111 G + + L P + + G R+ L D ++ + + ++ Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 112 GVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRKS--KGALMDPT 168 + +G RR + T + + +++ I+ L+++L ++ GA++D Sbjct: 90 SMFTVDGPE---HRRLRIKTTQALTRRRLDALKPTIERYVAELLDDLERAGADGAVVDLK 146 Query: 169 FLFQ-SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYF 227 +F + +I +++ +DQE ++L + FS+++ Sbjct: 147 SVFAYPLPMRVISALM---GVPSEDQE--QLLTWYKAFFSILT----------------- 184 Query: 228 PGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQN 287 + + + E++ Y V + + P D + + L++ ++ + + + Sbjct: 185 --PQDERLRVIDEMHGYFTEMVRRK-----TAEPGDDLTSALIYA----TDGETPLTEEE 233 Query: 288 LNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMP 347 + N +L AG ETT + + +L +P V Sbjct: 234 VIGNLQALVAAGHETTVSLILTAVRALLSHPEQLRLVRDGEIGW---------------- 277 Query: 348 YTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYF-EKPD 406 E I E R+ + + T+ +IP+ V + D D Sbjct: 278 --ETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADAD 335 Query: 407 AFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPE 466 F+ I F G IC G +AR E + + F P P Sbjct: 336 DFDITRAT--------AARHISFGHGPHICPGAALARLEAAIALPALFTRFPHLHPALPL 387 Query: 467 D 467 D Sbjct: 388 D 388 >3TYW-A nrPDB Length = 417 Score = 168 bits (425), Expect = 6e-42, Method: Composition-based stats. Identities = 73/434 (16%), Positives = 142/434 (32%), Gaps = 78/434 (17%) Query: 64 DVFTVHLGPRPVV-MLCGVEAIREALVD-KAEAFSGRGKIAMVDPFFRGYGVIF-----A 116 V V L R ++ + +RE L D + A R + + G F Sbjct: 43 PVARVTLPTRREAWVVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRT 102 Query: 117 NGNRWKVLRRFSVTTM--RDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLF-QS 173 + RR + R + +V+ R+ E ++ G +D + + Sbjct: 103 DAPEHTRYRRMLLPAFTVRRVRAMRPAVQARVDEILDGMLAA-----GGPVDLVSAYANA 157 Query: 174 ITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQ 233 ++ ++IC E L + + F ++ + G Q Sbjct: 158 VSTSVIC-------------ELLGIPRHDLEFFRDVTRISGSRN-----------STAEQ 193 Query: 234 VYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTL 293 V + L + +G V + RE P+D + + L+ + + L Sbjct: 194 VSEALGGLFGLLGGLVAERRE-----EPRDDLISKLV----TDHLVPGNVTTEQLLSTLG 244 Query: 294 SLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVI 353 AG ETT++ + LL+L P + + ++ + A + Sbjct: 245 ITINAGRETTTSMIALSTLLLLDRPELPAELRKDPD------------------LMPAAV 286 Query: 354 YEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHF 413 E+ R + + + G +P D V +L+ A HDP F+ P+ + Sbjct: 287 DELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHR- 345 Query: 414 LDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPED---IDL 470 + F G C+G+ +AR EL + T+L+ D + Sbjct: 346 --------TDNHHVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERDQVVVKH 397 Query: 471 TPQECGVGKIPPTY 484 G+ ++ T+ Sbjct: 398 DSATFGLEELMVTW 411 >1CPT-A nrPDB Length = 428 Score = 166 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 66/433 (15%), Positives = 133/433 (30%), Gaps = 64/433 (14%) Query: 58 FREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRG-----YG 112 K+ DV + + + E E L D+ A + G Sbjct: 53 IATKHADVMQI---GKQPGLFSNAEG-SEILYDQNNE-------AFMRSISGGCPHVIDS 101 Query: 113 VIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQ 172 + + R ++ + + K +EE I+ AQ ++ L G T Sbjct: 102 LTSMDPPTHTAYRGLTLNWFQPASIRK--LEENIRRIAQASVQRLLDFDGECDFMTDCAL 159 Query: 173 SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHR 232 +++ + + + LK+ F+ + A R Sbjct: 160 YYPLHVVMTALGVPE--DDEPLMLKLTQDFFGVHEPDEQAVAAP-------RQSADEAAR 210 Query: 233 QVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNT 292 + ++ + Y R S PKD + + L + + + + + +N Sbjct: 211 RFHETIATFYDYFNGFTVDRR-----SCPKDDVMSLLANSKLDGNY----IDDKYINAYY 261 Query: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 352 +++ AG +TTS++ + + + P + + Sbjct: 262 VAIATAGHDTTSSSSGGAIIGLSRNPEQLALAKSD------------------PALIPRL 303 Query: 353 IYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDH 412 + E R++ + T RG I + + L +A D F PD F+ Sbjct: 304 VDEAVRWTAPV-KSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITR 362 Query: 413 FLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTP 472 F + F G +CLG+ +A+ E+ +FF +L P + T Sbjct: 363 F---------PNRHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPPRLVATN 413 Query: 473 QECGVGKIPPTYQ 485 G +P + Sbjct: 414 FVGGPKNVPIRFT 426 >4MM0-A nrPDB Length = 399 Score = 166 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 75/421 (17%), Positives = 134/421 (31%), Gaps = 73/421 (17%) Query: 72 PRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRG--YGVIFANGNRWKVLRRFSV 129 P ++ E +R L D FS R + V+ + LRR Sbjct: 44 GDPGFLVTRYEDVRFVLSDPR--FSVRQDLPGAPRLTEMTFESVMTTDPPVHTRLRRLLS 101 Query: 130 TTMRDFGMGK-RSVEERIQEEAQCLIEELRKSKGALMDPTFLF-QSITANIICSIVFGKR 187 RDF + + R++E A+ L++E+ K KGA D +IC ++ Sbjct: 102 ---RDFTARRIERMRPRLEEIAEGLLDEMEK-KGAPADIVESLAVPFPITVICELLGVPM 157 Query: 188 FHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGH 247 + F + S+ G E + + +Y+ Sbjct: 158 VD---------VARFRGWADTMVSLTGYSMEDW--------------TAARDALESYLDG 194 Query: 248 SVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTL 307 V RE + DL+ + ++ E + ++ +L L AG E S L Sbjct: 195 LVAAKRE----NPGSDLLSALVATAAEDN-----ELTDHDVRSLSLILLLAGYEPASNQL 245 Query: 308 RYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGV 367 L +L++P + R+ + + E+ R++ + Sbjct: 246 GSSVLTLLRFPDRLAELRRDPG------------------LLPSAVEELMRYAPAGDGAL 287 Query: 368 PHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFI 427 + + + IP ++ V A DP F+ P D Sbjct: 288 FRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDR---------PDNQHT 338 Query: 428 PFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPEDIDLTPQE---CGVGKIPPT 483 G CLG +AR EL + +L+ F +A + + G +IP T Sbjct: 339 ALGHGIHFCLGAALARVELQVAIGALLRRFPRLALATDESGLRWSSPGSMLSGFAEIPVT 398 Query: 484 Y 484 + Sbjct: 399 W 399 >6CVC-A nrPDB Length = 433 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 81/470 (17%), Positives = 147/470 (31%), Gaps = 77/470 (16%) Query: 34 PRPLPL----LGNLLQMDRRGLL--KSFLRFREKYGDVF--TVHLGPRPVV----MLCGV 81 P +PL LG+L R +F R + F + L L Sbjct: 20 PPEVPLADIELGSLEFWGRDDDFRDGAFATLRREAPISFWPPIELAGLTAGKGHWALTKH 79 Query: 82 EAIREALVDKAEAFSGRGKIAM--VDPFFRGY--GVIFANGNRWKVLRRFSVTTMRDFGM 137 + I A E F I + P Y +I + R + LR + Sbjct: 80 DDIHFA-SRHPEIFHSSPNIVIHDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVV 138 Query: 138 GKRSVEERIQEEAQCLIEEL-RKSKGALMDPTFLF-QSITANIICSIVFGKRFHYQDQEF 195 + +E ++E A L+ + D + IIC ++ +D E Sbjct: 139 AR--IEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMM---GIPEEDHE- 192 Query: 196 LKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRET 255 +F+ T ++ L F FL+ I Y + R Sbjct: 193 ----QIFHWTNVILGFGDPDLTTDFDEFLQVSMA-----------IGGYATALADDRRV- 236 Query: 256 LDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315 + DL + + E S + + + L AG ETT + +G L + Sbjct: 237 ---NHHGDLTTSLV-----EAEVDGERLSSSEIAMFFILLVVAGNETTRNAISHGMLALS 288 Query: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375 +YP + + + + + + EI R++ + + + ++Q Sbjct: 289 RYPDERAKWWSDFDGLAA-----------------TAVEEIVRWASPV-VYMRRTLSQDV 330 Query: 376 SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPF-SLGKR 434 RG + +V L +A D F P F+ + + F G Sbjct: 331 DLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFD---------VTRNPNPQVGFGGGGAH 381 Query: 435 ICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTY 484 CLG +AR E+ + F + + L+ G+ ++P + Sbjct: 382 FCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKRLPVAW 431 >3R9C-A nrPDB Length = 418 Score = 164 bits (414), Expect = 9e-41, Method: Composition-based stats. Identities = 63/367 (17%), Positives = 121/367 (32%), Gaps = 54/367 (14%) Query: 114 IFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQS 173 +F + LR + + +E I L++ + + L+D L Sbjct: 98 LFLDPPDHTRLRGLVSKAFAPRVIKR--LEPEITALVDQLLDAVDGPEFNLID--NLAYP 153 Query: 174 ITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQ 233 + +IC ++ G + +F + L ++ G+ +LF + Sbjct: 154 LPVAVICRLL-GVPIEDE-PKFSRASALLAAALDPFLALTGETSDLF-----------DE 200 Query: 234 VYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTL 293 K + Y+ +++ R T P + + + L+ +E + + + + Sbjct: 201 QMKAGMWLRDYLRALIDERRRT-----PGEDLMSGLVAVE----ESGDQLTEDEIIATCN 251 Query: 294 SLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVI 353 L AG ETT + L ML+ P + + + AVI Sbjct: 252 LLLIAGHETTVNLIANAALAMLRTPGQWAALAADGSR------------------ASAVI 293 Query: 354 YEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHF 413 E R+ + + V + + +PK + L+L+ A DP PD F+PD Sbjct: 294 EETMRYDPPVQL-VSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPDR- 351 Query: 414 LDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQ 473 + F G CLG +AR E + + F A + Sbjct: 352 --------AQIRHLGFGKGAHFCLGAPLARLEATVALPALAARFPEARLSGEPEYKRNLT 403 Query: 474 ECGVGKI 480 G+ + Sbjct: 404 LRGMSTL 410 >1UED-A nrPDB Length = 406 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 77/457 (16%), Positives = 152/457 (33%), Gaps = 86/457 (18%) Query: 44 LQMDRRGLLKSFLRFREKYGDVFTV------HLGPRPVVMLCGVEAIREALVDKAEAFSG 97 L+ + +F +G + + LG V G E +R L D E F+ Sbjct: 20 LRTNCDPHEDNFG--LRAHGPLVRIVGESSTQLGRDFVWQAHGYEVVRRILGDH-EHFTT 76 Query: 98 RGKI------AMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEEA 150 R + A V+ F G + + LR+ +F + + R +E IQ Sbjct: 77 RPQFTQSKSGAHVEAQFVGQ-ISTYDPPEHTRLRKMLTP---EFTVRRIRRMEPAIQSLI 132 Query: 151 QCLIEELRKSKGALMDPTFLFQSIT-ANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLI 209 ++ L ++G D LF A+ +C ++ R +EF++ + Sbjct: 133 DDRLDLLE-AEGPSADLQGLFADPVGAHALCELLGIPR--DDQREFVRRIRRNA------ 183 Query: 210 SSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYL 269 + + N Y+ + + + R D D L Sbjct: 184 ----------------DLSRGLKARAADSAAFNRYLDNLLARQRA--------DPDDGLL 219 Query: 270 LHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIE 329 + ++ + + + L +L G ET + + +G L +L P E ++ E Sbjct: 220 GMIVRDHGDN---VTDEELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPE 276 Query: 330 QVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVF 389 + E V+ E+ R+ + P + + G +I V Sbjct: 277 K------------------AERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVL 318 Query: 390 LILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLF 449 + A D PD + + ++ + F G C+G +AR+ L + Sbjct: 319 CSILMANRDEALTPDPDVLDANRAAVSD---------VGFGHGIHYCVGAALARSMLRMA 369 Query: 450 FTTILQNFS-MASPVAPEDIDLTPQECGV-GKIPPTY 484 + T+ + F + V E++ ++P T+ Sbjct: 370 YQTLWRRFPGLRLAVPIEEVKYRSAFVDCPDQVPVTW 406 >5Z9I-A nrPDB Length = 398 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 73/406 (17%), Positives = 124/406 (30%), Gaps = 60/406 (14%) Query: 87 ALVDKAEAFSG---RGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVE 143 A++ + FS R +D + + + LR + K +E Sbjct: 46 AILSNPKVFSSDTMRLDPIKLDEAIVEGDFAHTDPPKHRRLRGLVDHAFTPSLVAK--ME 103 Query: 144 ERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFY 203 R+ L++ + D F + I+ S + L + Sbjct: 104 SRVHGIIHELLD--GVEGKSQFDLVAEFAAPLPLIMIS------------DLLGVPESDR 149 Query: 204 QTFSLISSVFGQLFELF--SGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAP 261 F E F + + + L E+ Y + R+ P Sbjct: 150 ALFRQWMDKMLDGSEKFESPETVLEQEEELHKELELLWEMRDYWHERAAESRKR-----P 204 Query: 262 KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVA 321 ++ + + L+H E + + ++ L G TT+ + L + + Sbjct: 205 REDLISQLVHAEVDGQK----LNDSQISNIANRLLVNGHLTTAMLIANTMLCLDAFSDQD 260 Query: 322 ERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYI 381 RV DR+ +P A++ E R+ + GV G + Sbjct: 261 ARVRA---------------DRSLVP---ALLEESMRYMSPI-CGVGRATNSEVEVAGTV 301 Query: 382 IPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGI 441 IPKD + + A D FEKPD F+ A + A + F G CLG + Sbjct: 302 IPKDQLLLVWTGAANRDERQFEKPDVFD---------AGRSPNAHLGFGRGIHFCLGRQL 352 Query: 442 ARAELFLFFTTILQNFSM--ASPVAPEDIDLTPQECGVGKIPPTYQ 485 AR E +L A P P GV +P Q Sbjct: 353 ARMESKAAVEILLDRLPTLRADPANPPTFLQVVDASGVATLPVVTQ 398 >4TRI-A nrPDB Length = 407 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 50/263 (19%), Positives = 88/263 (33%), Gaps = 39/263 (14%) Query: 228 PGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQN 287 A +++ + + K R P D + + L++ E E S Sbjct: 172 EAAIQKLMDTFAAYTEFTKDVITKRRA-----EPTDDLFSVLVNSEVE----GQRMSDDE 222 Query: 288 LNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMP 347 + TL + G ETT TL G +L++ + + +++ Sbjct: 223 IVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVD------------------ 264 Query: 348 YTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDA 407 I E+ R++ + + +T T F G + ++ L+ +A D F PD Sbjct: 265 LLPGAIEEMLRWTSPV-KNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDN 323 Query: 408 FNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPED 467 F D + + F G CLG +AR EL L +L+ Sbjct: 324 FRIDR---------NPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAP 374 Query: 468 IDLTPQECGVGKIPPTYQIRFLP 490 + L P P + + F P Sbjct: 375 VPLRP--ANFVSGPESMPVVFTP 395 >5XW2-A nrPDB Length = 419 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 65/414 (15%), Positives = 117/414 (28%), Gaps = 57/414 (13%) Query: 78 LCGVEAIREALVDKA--EAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDF 135 + G E L D + R D F ++ + + LR+ Sbjct: 57 VYGYAEAIEVLGDPGTFSSHMSRLLPMGADEAFTEGDLLQTDPPDHRELRKLVSHAFTPK 116 Query: 136 GMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQ-SITANIICSIVFGKRFHYQDQE 194 + +E RI Q L++ + D + ++ E Sbjct: 117 VVA--ELEPRITALTQELLDA--VADRDTFDLMTALAYPLPVTVVA-------------E 159 Query: 195 FLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRE 254 L + + F + S ++ P ++++ + + +H Sbjct: 160 LLSIPSADRHLFEGWMTEIVHSLGDVS--MEDAPEDQERIFEAGMAPMRKMLEYLREHAA 217 Query: 255 TLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM 314 DL+ + E + ++ L AG TT+ + L + Sbjct: 218 ECRRRPRGDLMGKLI-----EAEVDGRRLTDNHIVNFAKMLLIAGYLTTTMLIGNTVLCL 272 Query: 315 LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH 374 YP A RV DR+ +P + E RF + T+ Sbjct: 273 DSYPEQAARVRA---------------DRSLIPGL---LEESMRFLSPVA-ATYRATTRD 313 Query: 375 TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434 G + D V + A D F +P+ F+ + + F G Sbjct: 314 VEVAGQRLSADQMVMVWFGAANRDARQFAEPELFD---------MTRGPNPHLGFGRGIH 364 Query: 435 ICLGEGIARAELFLFFTTILQNFS--MASPVAPEDIDLTPQECGVGKIPPTYQI 486 CLG +AR E + +L F P P GV +P + Sbjct: 365 FCLGGPLARMEGRVALDHLLDRFPELYTDPERPPTFMPGFDTTGVSSLPLRTSL 418 >6GMF-A nrPDB Length = 397 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 69/394 (17%), Positives = 121/394 (30%), Gaps = 65/394 (16%) Query: 69 HLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDP-----FFRGYGVIFANGNRWKV 123 L P+ + + + + L D A+ FS RG A + ++ + R Sbjct: 31 RLQPQGFMAVGRYQDVARVLHD-AKGFSNRGWAASLPRGVKWDTSMPPSIVQVDPPRHGK 89 Query: 124 LRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIV 183 LR + + +E RI++ A L++ LR K + + +I Sbjct: 90 LRTLVTKAFTPRTVAQ--LEPRIRDIAHELVDGLR-GKSTFEATVEVTVPMPMIVIA--- 143 Query: 184 FGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINA 243 E L + F S L G Q+ ++ QE A Sbjct: 144 ----------EMLGVAPERRADFKRWSDDMVGSLALVRV------GNAAQLERSTQEFYA 187 Query: 244 YIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETT 303 Y + E +DLI L + + + +L AG ETT Sbjct: 188 YFSEVL----EERRREPREDLISQLL-----AAEVDGEKLTAGEVLSFANTLLIAGNETT 238 Query: 304 STTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLL 363 ++ + + + +P A + AV+ E+ R+ Sbjct: 239 TSLIGNALVALTDHPEQLAAAQ------------------ADLSLVPAVVEEVLRYESPA 280 Query: 364 PMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKT 423 + IP + V +L++A D F PD F+ T Sbjct: 281 QC-IFRQTMTDVEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHR---------DT 330 Query: 424 EAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 + + F L C+G +AR E + +L Sbjct: 331 KGHLAFGLDIHFCIGAPLARLEAKVMLEVLLARL 364 >6G5O-A nrPDB Length = 399 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 57/288 (19%), Positives = 104/288 (36%), Gaps = 46/288 (15%) Query: 208 LISSVFGQLFELFSGFLKYFPGAHRQVY-KNLQEINAYIGHSVEKHRETLDPSAPKDLID 266 L+++ F + S F + + YI +++ E P D + Sbjct: 138 LLNTPFSESETWISWGTHVFRSEGEALDGDKANILYHYIDEQIDRASE-----NPGDDMY 192 Query: 267 TYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYR 326 + LL+ E E + + + + + F G +T + + ++P ER+ + Sbjct: 193 SVLLNSEFE----GRKLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRK 248 Query: 327 EIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDT 386 E PE+ RA + E+ R+ L + +VT+ T + + D+ Sbjct: 249 E----------PEITGRA--------VEEMIRYFSPL-TQMGRVVTEDTHVCEHAVKADS 289 Query: 387 EVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAEL 446 + L ++A D FE P+ D K + F CLG AR L Sbjct: 290 RISLCWASANRDAAVFENPNEIVLDR---------KVNPHVGFGFSHHNCLGATHARQIL 340 Query: 447 FLFFTTILQNFS----MASPVAPEDIDLTPQECGVGKIPPTYQIRFLP 490 + T+ Q + + ED+D ++ G I QI+F P Sbjct: 341 KILLQTLAQKVASFEILDYKENIEDLDHFQRKVGFHNI----QIKFNP 384 >1ODO-A nrPDB Length = 408 Score = 159 bits (401), Expect = 4e-39, Method: Composition-based stats. Identities = 56/420 (13%), Positives = 112/420 (26%), Gaps = 74/420 (17%) Query: 78 LCGVEAIREALVDKAEAFSGRGKIAMVDPFFRG---------YGVIFANGNRWKVLRRFS 128 + +++ L + R + A G + LRR Sbjct: 43 VSDPVLLKQLLTSSDVSKDARAHWPAFGEVVGTWPLALWVAVENMFTAYGPNHRKLRRLV 102 Query: 129 VTTMRDFGMGKRSVEERIQEEAQCLIEELRKSK-GALMDPTFLFQ-SITANIICSIVFGK 186 ++ ++ L++ L + G +D + +I Sbjct: 103 APAFS--ARRVDAMRPAVEAMVTGLVDRLAELPAGEPVDLRQELAYPLPIAVIG------ 154 Query: 187 RFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIG 246 + + F + + +F L + N + + Sbjct: 155 -------HLMGVPQDRRDGFRAL------VDGVFDTTLD-----QAEAQANTARLYEVLD 196 Query: 247 HSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTT 306 + R T P D + + L+ ++ + S + L L + AG ETT Sbjct: 197 QLIAAKRAT-----PGDDMTSLLIAARDDEGD-GDRLSPEELRDTLLLMISAGYETTVNV 250 Query: 307 LRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMG 366 + +L P V + V+ E R + Sbjct: 251 IDQAVHTLLTRPDQLALVRKGEVTWAD------------------VVEETLRHEPAVKHL 292 Query: 367 VPHIVTQHTSF-RGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEA 425 + G I + + + A P + E D F+ + Sbjct: 293 PLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFDATRTVKE--------- 343 Query: 426 FIPFSLGKRICLGEGIARAELFLFFTTILQNF-SMASPVAPEDIDLTPQ--ECGVGKIPP 482 + F G CLG +AR E+ L ++ F + E++ P G ++P Sbjct: 344 HLAFGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLADPAEELPPVPSLISNGHQRLPV 403 >6A7J-A nrPDB Length = 411 Score = 158 bits (399), Expect = 5e-39, Method: Composition-based stats. Identities = 64/438 (14%), Positives = 133/438 (30%), Gaps = 80/438 (18%) Query: 63 GDVFTVHL-GPRPVVMLCGVEAIREALVDKAEAFS-------GRG----KIAMVDPFFRG 110 G + V L G V + + R L D RG ++ G Sbjct: 26 GPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKDINVWNAWQRGEIPADWPLIGLVNPG 85 Query: 111 YGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSK-GALMDPTF 169 ++ +G + LR + + K + I+ +E L G +D Sbjct: 86 RSMLTVDGPDHRRLRTLVAQALTVKRVEK--LRAGIEALTNASLERLAALPAGEPVDLKA 143 Query: 170 LFQ-SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFP 228 F + N+I ++ + ++ LF + FS + Sbjct: 144 EFAYPLPMNVISELMGVDAADHP-----RLKELFEKFFSTQTPP---------------- 182 Query: 229 GAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNL 288 +V + + ++ VE+ + P D + + L+ S + + + Sbjct: 183 ---EEVPQMMADLGTLFTKIVEEKKA-----NPGDDLTSALIAA----SEDGDHLTDEEI 230 Query: 289 NLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPY 348 + AG ETT + + + +P ++V ++P+ Sbjct: 231 LNTLQLIIAAGHETTISLIVNVVEALAIHPEQRKKVLS-----------------GEIPW 273 Query: 349 TEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYF-EKPDA 407 E VI E R++ + T+ ++PK + + D + Sbjct: 274 -EGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGD 332 Query: 408 FNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPE 466 F+ A + I F G +C G ++R E + + + F + V Sbjct: 333 FD---------ATRTPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPAA 383 Query: 467 DIDLTPQEC--GVGKIPP 482 ++ P + +P Sbjct: 384 ELRNKPIVTQNDLHDLPV 401 >3P3Z-A nrPDB Length = 416 Score = 157 bits (397), Expect = 8e-39, Method: Composition-based stats. Identities = 62/364 (17%), Positives = 116/364 (31%), Gaps = 59/364 (16%) Query: 123 VLRRFSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQS-ITANIIC 180 RR F + +V+ ++ + LI++L + D F + A ++C Sbjct: 107 DHRRLRGLATHPFTPRRITAVQPFVRSTVEQLIDKLPQGD---FDFVQHFPHPLPALVMC 163 Query: 181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE 240 ++ F +D + + L++ +S+ L +V + L Sbjct: 164 QLL---GFPLEDYDTVGRLSIETNLGLALSNDQDILV---------------KVEQGLGR 205 Query: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300 + Y+ ++EK + P D + + ++ + L ++ AG Sbjct: 206 MFDYLVAAIEKRKV-----EPGDDLTSDIVRAFHD-----GVLDDYELRTLVATVLVAGY 255 Query: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360 ETT+ L ++P ++ E + E+ R+S Sbjct: 256 ETTNHQLALAMYDFAQHPDQWMKIKENPE------------------LAPQAVEEVLRWS 297 Query: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420 LP+ + + G IP T VF+ A DP F D F+ + Sbjct: 298 PTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDI--------TV 349 Query: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI 480 K+ I F G CLG +AR EL + G + Sbjct: 350 KREAPSIAFGGGPHFCLGTALARLELTEAVAALATRLDPPQIAGEITWRHELGVAGPDAL 409 Query: 481 PPTY 484 P + Sbjct: 410 PLRF 413 >4Z5Q-A nrPDB Length = 423 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 67/431 (15%), Positives = 128/431 (29%), Gaps = 70/431 (16%) Query: 32 PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHL-GPRPVVMLCGVEAIREALVD 90 P P P G+ + K F GD V L P ++ + R L D Sbjct: 33 PAPVAYPFTGSEGLELSQSYAKLFED-----GDPIRVQLPFGEPAWLVTRYDDARFVLTD 87 Query: 91 K--AEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQE 148 + + + + + P ++ + LR + S I E Sbjct: 88 RRFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRTLVSKAFTPRRI--ESKRAWIGE 145 Query: 149 EAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSL 208 A L+ +++ +I +IC E L + Sbjct: 146 LAAGLVADMKAGGAPAELVGSYALAIPVTVIC-------------ELLGVPEDDRTRLRG 192 Query: 209 ISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTY 268 EL + ++ ++ Y V++ R P+D + + Sbjct: 193 WCDAALSTGEL----------TDEECVQSFMDLQKYFEDLVKERRA-----EPRDDLTSA 237 Query: 269 LLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREI 328 L+ +AH + L +S+ G ETT++ + ++ + + R+ + Sbjct: 238 LIEAR----DAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRELWTRLCADP 293 Query: 329 EQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGV-PHIVTQHTSFRGYIIPKDTE 387 E + A + E+ RF G+ P + + G ++ + Sbjct: 294 EAI------------------PAAVEELLRFVPFAANGISPRYALEDMTVGGVLVREGEP 335 Query: 388 VFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELF 447 V + S D F+ D D + F G CLG +AR EL Sbjct: 336 VIVDTSAVNRDGLVFDNADEVVIDRAD---------NRHMVFGHGAHHCLGAHLARVELQ 386 Query: 448 LFFTTILQNFS 458 +++ Sbjct: 387 EALKALVEGMP 397 >5XJN-A nrPDB Length = 455 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 69/454 (15%), Positives = 133/454 (29%), Gaps = 74/454 (16%) Query: 46 MDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSG-------- 97 D ++ R++ +F +G ++ + I+ D E FS Sbjct: 59 FDMHNPFPAYKELRQEEPVMFDERIG---YWVVTKYDDIKTTF-DDWETFSSENAQAPVR 114 Query: 98 -RGKIAMVDPFFRGY----GVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQC 152 RG A G+ G+ +R + +++E I+ Sbjct: 115 KRGPQATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRY--KALEPDIRAMVID 172 Query: 153 LIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSV 212 +E++ + + D I + G D T+ S Sbjct: 173 RVEKMLANDQHVGDMVSDLAYDIPTITILTLIGADISMVD------------TYKRWSDS 220 Query: 213 FGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHM 272 + + P AH V + + + A D + Sbjct: 221 RAAMTWGDLSDEEQIPHAHNLV-------------EYWQECQRMVADAHAHGGDNLTADL 267 Query: 273 EKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVI 332 + + E + + SL FAG ETT+T + F ++L +P + + Sbjct: 268 VRAQQE-GQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE------ 320 Query: 333 GPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLIL 392 A + E+ R+S + +G + T G I + V L++ Sbjct: 321 ------------NPKLIPAAVDEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVLLLM 367 Query: 393 STALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTT 452 +A D FE + F+ + F G CLG +A+ + + Sbjct: 368 GSANRDEARFENGEEFDISR--------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEE 419 Query: 453 ILQNFSMASPVAPEDIDLTPQEC--GVGKIPPTY 484 + + VA + I +P T+ Sbjct: 420 VTRLVPSLHLVADKAIGFRENLSFRVPTSVPVTW 453 >5GWE-A nrPDB Length = 405 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 69/454 (15%), Positives = 133/454 (29%), Gaps = 74/454 (16%) Query: 46 MDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSG-------- 97 D ++ R++ +F +G ++ + I+ D E FS Sbjct: 9 FDMHNPFPAYKELRQEEPVMFDERIG---YWVVTKYDDIKTTF-DDWETFSSENAQAPVR 64 Query: 98 -RGKIAMVDPFFRGY----GVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQC 152 RG A G+ G+ +R + +++E I+ Sbjct: 65 KRGPQATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRY--KALEPDIRAMVID 122 Query: 153 LIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSV 212 +E++ + + D I + G D T+ S Sbjct: 123 RVEKMLANDQHVGDMVSDLAYDIPTITILTLIGADISMVD------------TYKRWSDS 170 Query: 213 FGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHM 272 + + P AH V + + + A D + Sbjct: 171 RAAMTWGDLSDEEQIPHAHNLV-------------EYWQECQRMVADAHAHGGDNLTADL 217 Query: 273 EKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVI 332 + + E + + SL FAG ETT+T + F ++L +P + + Sbjct: 218 VRAQQE-GQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE------ 270 Query: 333 GPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLIL 392 A + E+ R+S + +G + T G I + V L++ Sbjct: 271 ------------NPKLIPAAVDEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVLLLM 317 Query: 393 STALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTT 452 +A D FE + F+ + F G CLG +A+ + + Sbjct: 318 GSANRDEARFENGEEFDISR--------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEE 369 Query: 453 ILQNFSMASPVAPEDIDLTPQEC--GVGKIPPTY 484 + + VA + I +P T+ Sbjct: 370 VTRLVPSLHLVADKAIGFRENLSFRVPTSVPVTW 403 >2XKR-A nrPDB Length = 398 Score = 155 bits (391), Expect = 5e-38, Method: Composition-based stats. Identities = 69/399 (17%), Positives = 126/399 (31%), Gaps = 63/399 (15%) Query: 90 DKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEE 149 + E FS G I P +I + + R+ + + E I Sbjct: 54 RQPELFSNAGGIRPDQPALPM--MIDMDDPAHLLRRKLVNAGFTRKRVKDK--EASIAAL 109 Query: 150 AQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLI 209 LI+ + +G L + +I ++ G R +D FL+ + S Sbjct: 110 CDTLIDAVC-ERGECDFVRDLAAPLPMAVIGDML-GVRPEQRD-MFLRWSDDLVTFLSSH 166 Query: 210 SSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYL 269 S + N + ++ R P D + + L Sbjct: 167 VSQEDFQITM----------------DAFAAYNDFTRATIAARRAD-----PTDDLVSVL 205 Query: 270 LHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIE 329 + E + S L + TL + G ETT TL G +L+ + + R+ Sbjct: 206 VSSEVD----GERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRD-- 259 Query: 330 QVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVF 389 I E+ R++ + + ++T T F G + ++ Sbjct: 260 ----------------PSLLPGAIEEMLRWTAPV-KNMCRVLTADTEFHGTALCAGEKMM 302 Query: 390 LILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLF 449 L+ +A D F +P+ F+ + + F G CLG +AR EL L Sbjct: 303 LLFESANFDEAVFCEPEKFDVQR---------NPNSHLAFGFGTHFCLGNQLARLELSLM 353 Query: 450 FTTILQNF-SMASPVAPEDIDLTPQ--ECGVGKIPPTYQ 485 +L+ + + L P G+ +P + Sbjct: 354 TERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFT 392 >1GWI-A nrPDB Length = 411 Score = 154 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 60/419 (14%), Positives = 124/419 (29%), Gaps = 72/419 (17%) Query: 64 DVFTVHLGPRPVVMLCGVEAIREALV----DKAEAFSGRGKIAMVDPFFRGYGVIFANGN 119 V+ V +L +++ V + E + ++ G ++ +G Sbjct: 42 PVWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPA---DWPLIGLANPGRSMLTVDGA 98 Query: 120 RWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQ-SITANI 178 + LR + + + RI E L++EL + G ++D F + + Sbjct: 99 EHRRLRTLVAQALTVRRV--EHMRGRITELTDRLLDELP-ADGGVVDLKAAFAYPLPMYV 155 Query: 179 ICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL 238 + + ++ ++ LF + FS + +V L Sbjct: 156 VADL-----MGIEEARLPRLKVLFEKFFSTQTPP-------------------EEVVATL 191 Query: 239 QEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFA 298 E+ + + +V R AP D + + L+ S + + + A Sbjct: 192 TELASIMTDTVAAKRA-----APGDDLTSALIQA----SENGDHLTDAEIVSTLQLMVAA 242 Query: 299 GTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQR 358 G ETT + + + + +P V + AV+ E R Sbjct: 243 GHETTISLIVNAVVNLSTHPEQRALVLSGEAEW------------------SAVVEETLR 284 Query: 359 FSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDP-HYFEKPDAFNPDHFLDAN 417 FS + + +IP + + D + D F+ Sbjct: 285 FSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRFDLTRTSG-- 342 Query: 418 GALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPEDIDLTPQEC 475 I F G +C G ++R E + + F + V ++ P Sbjct: 343 ------NRHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPAAELRNKPVVT 395 >6A7I-A nrPDB Length = 411 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 55/389 (14%), Positives = 118/389 (30%), Gaps = 68/389 (17%) Query: 100 KIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRK 159 ++ G ++ +G + LR + + + I+ +E+L Sbjct: 75 DWPLIGLANPGRSMLTVDGADHRRLRTLVAQALTVKRV--ERLRAGIEALTNASLEKLAA 132 Query: 160 SK-GALMDPTFLFQ-SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLF 217 G +D F + N+I ++ + ++ LF + FS + Sbjct: 133 LPAGEPVDLKAEFAYPLPMNVISELMGVDAADHP-----RLKELFEKFFSTQTPP----- 182 Query: 218 ELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKS 277 +V + + ++ A V+ R + P D + + L+ S Sbjct: 183 --------------EEVPQMMADLGALFTKIVDAKR-----TNPGDDLTSALIAA----S 219 Query: 278 NAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRP 337 + + + + AG ETT + + + +P ++V G Sbjct: 220 ENGDHLTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHPEQRKKVLNGEIGWDG---- 275 Query: 338 PELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALH 397 VI E R++ + T+ I+PK + + Sbjct: 276 --------------VIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGR 321 Query: 398 DPHYF-EKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQN 456 D + F+ A + I F G +C G ++R E + + + Sbjct: 322 DEEQYGPTAGEFD---------ATRTPNRHIAFGHGPHVCPGAALSRLEAGIALPALYER 372 Query: 457 FS-MASPVAPEDIDLTPQEC--GVGKIPP 482 F + V D+ P + ++P Sbjct: 373 FPELDLAVPASDLRNKPIVTQNDLHELPV 401 >6HQG-A nrPDB Length = 425 Score = 152 bits (384), Expect = 3e-37, Method: Composition-based stats. Identities = 60/394 (15%), Positives = 119/394 (30%), Gaps = 56/394 (14%) Query: 93 EAFSGRGKIAMVDPFFRGYGVIFA--NGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEA 150 E FS I + DP +F + + V R+ + + +E I+E A Sbjct: 80 EVFSSEPTIVLPDPADDFTLPMFIAMDPPKHDVQRKTVQPIVAPNHLA--YLEPIIRERA 137 Query: 151 QCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLIS 210 ++++L + + T + F + ++ K+ S Sbjct: 138 GKILDDLPIGEEINWVDKVSIELTTMTLATL------FDFPWEDRRKLTFWSDVATSAPE 191 Query: 211 SVFGQLFELFSGFLKYFPGAHRQVYKN-LQEINAYIGHSVEKHRETLDPSAPKDLIDTYL 269 S + P H + + L E Y + + PK + + L Sbjct: 192 SGILGTTD---------PEEHENLRRQTLFECVDYFMRLWNER----VNAPPKPDLISML 238 Query: 270 LHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIE 329 H E K+ N + L G +TT T+ L + + P ++ Sbjct: 239 AHGESTKN-----MDRMEYLGNLILLIVGGNDTTRNTISGSVLALHQNPDQDRKLRE--- 290 Query: 330 QVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVF 389 A++ E R+ L + + G I + +V Sbjct: 291 ---------------NPGLIPAMVSETIRWQTPLA-YMRRRAKRDFELGGKTIREGDKVA 334 Query: 390 LILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLF 449 + + D ++P+ + + + + F G C+G +A +L + Sbjct: 335 MWYVSGNRDEEVIDRPNDYWIER--------PRVRQHLSFGFGVHRCVGNRLAELQLKII 386 Query: 450 FTTILQNFSMASPVAPEDIDLTPQECGVGKIPPT 483 + IL F V P + G ++P Sbjct: 387 WEEILARFPRLEVVGPPRRVYSSFVKGYEELPVV 420 >5XNT-A nrPDB Length = 411 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 67/393 (17%), Positives = 120/393 (30%), Gaps = 67/393 (17%) Query: 81 VEAIREALVDKAEAFSGRGKIAMVDPFFRGYG-------VIFANGNRWKVLRRFSVTTMR 133 E ++ L D S R + + G + A+ + R Sbjct: 49 YEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVPDKIKITEADPPEHRKRRSLLAAAFT 108 Query: 134 DFGMGKRSVEERIQEEAQCLIEELRKSKGALMDP-TFLFQSITANIICSIVFGKRFHYQD 192 + ++ E RIQE A LIEE+ + +D L + ++ Sbjct: 109 PRSL--QNWEPRIQEIADELIEEM--DEETEIDIVQSLASPLPIIVMS------------ 152 Query: 193 QEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKH 252 + + + + F + + + +E Y+ V + Sbjct: 153 -DLMGVPSKDRLLFKKWVDIL-----FLPFDKEKQEEVNELKQVAAKEYYQYLYPIVVQK 206 Query: 253 RETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFL 312 R P D I + LL E + F+ + T+ + AG ETTS L F Sbjct: 207 R-----LNPADDIISDLLKAEVDGEM----FTDDEVVRTTMLILGAGVETTSHLLANSFY 257 Query: 313 LML-KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIV 371 +L V + ++ ++ + E+ R+ + + V Sbjct: 258 SLLYDDKEVYQELHENLD------------------LVPQAVEEMLRYR-FNLIKLDRTV 298 Query: 372 TQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSL 431 + G + + V + +S A D FE N + + F Sbjct: 299 KEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLNIHRPNNKK--------HLTFGN 350 Query: 432 GKRICLGEGIARAELFLFFTTILQNFSMASPVA 464 G CLG +AR E + TT L+ F V Sbjct: 351 GPHFCLGAPLARLEAKIALTTFLKKFKHIEAVP 383 >3A1L-A nrPDB Length = 425 Score = 151 bits (381), Expect = 7e-37, Method: Composition-based stats. Identities = 68/387 (17%), Positives = 118/387 (30%), Gaps = 60/387 (15%) Query: 75 VVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRG---YGVIFANGNRWKVLRRFSVTT 131 V +L R A V + + I R ++F + LR T Sbjct: 57 VRVLSNRRLGRNARVASGDTDTAPVPIPTEHRALRTVVENWLVFLDPPHHTELRSLLTTE 116 Query: 132 MRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQ 191 + + RI E A L++ LR + + +I +++ + Sbjct: 117 FSPSIVT--GLRPRIAELASALLDRLRAQR-RPDLVEGFAAPLPILVISALL---GIPEE 170 Query: 192 DQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEK 251 D +L+ + Q S + G+ + + QE Y V++ Sbjct: 171 DHTWLRANAVALQEASTTRARDGR--------------GYARAEAASQEFTRYFRREVDR 216 Query: 252 HRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGF 311 L + + S S + + L AG ETT+ L Sbjct: 217 RGGDDRDDL---------LTLLVRARDTGSPLSVDGIVGTCVHLLTAGHETTTNFLAKAV 267 Query: 312 LLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIV 371 L + + V + + E T A + E+ R+ + V Sbjct: 268 LTLRAHRDVLDELRTTPES------------------TPAAVEELMRYDPPVQ-AVTRWA 308 Query: 372 TQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSL 431 + + IP+ + V +L +A DP F PD + E + F L Sbjct: 309 YEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVHR---------AAERQVGFGL 359 Query: 432 GKRICLGEGIARAELFLFFTTILQNFS 458 G CLG +ARAE + +L Sbjct: 360 GIHYCLGATLARAEAEIGLRALLDGIP 386 >4XE3-A nrPDB Length = 407 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 71/450 (15%), Positives = 138/450 (30%), Gaps = 80/450 (17%) Query: 24 PNTHDRLPPGPRPLP----LLGNLLQMDRRGLLKSFLRFREKYGD--VFTVHLGPRPVVM 77 P D +P P LP L + ++ R + R R YG+ + V ++ Sbjct: 8 PTPADAVPAYPFSLPHALDLDPHYAELRRDEPV---SRVRLPYGEGTAWLVTRMSDARIV 64 Query: 78 LCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGM 137 L A D A + R +P GV+ + LRR Sbjct: 65 LGDSRFSTAAATDPA---TPRMFPTPPEP----DGVLAQDPPDHTRLRRLVGKAFT--AR 115 Query: 138 GKRSVEERIQEEAQCLIEELRKSKGALMDPT-FLFQSITANIICSIVFGKRFHYQDQEFL 196 + R++ L++++ G+ D FL +IC ++ +D++ Sbjct: 116 RVEEMRPRVRSLVDSLLDDMVAH-GSPADLVEFLAVPFPVAVICELL---GVPLEDRDLF 171 Query: 197 KMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL 256 + + L ++ + Q+ Y+ V + R Sbjct: 172 RTFSD--------------------AMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRR--- 208 Query: 257 DPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLK 316 + +DL+ L + + + + +SL AG ET+ + L+L Sbjct: 209 -DAPTEDLLGALALATDNDDH-----LTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLT 262 Query: 317 YPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMG-VPHIVTQHT 375 E + A A + E+ R++ L+ G + T+ Sbjct: 263 ERKRYESL------------------VADPALVPAAVEEMLRYTPLVSAGSFVRVATEDV 304 Query: 376 SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRI 435 + + ++A D F+ D + + I F G Sbjct: 305 ELSTVTVRAGEPCVVHFASANRDEEVFDHADELDFHR---------ERNPHIAFGHGAHH 355 Query: 436 CLGEGIARAELFLFFTTILQNFSMASPVAP 465 C+G + R EL + +++ F P Sbjct: 356 CIGAQLGRLELQEALSALVRRFPTLDLAEP 385 >2WIO-A nrPDB Length = 431 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 56/342 (16%), Positives = 108/342 (31%), Gaps = 59/342 (17%) Query: 117 NGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLF-QSIT 175 + + LR+ + + +E RI++ + L+ G D + + Sbjct: 111 DPPEHRALRKVVSSAFTPRTISD--LEPRIRDVTRSLLA----DAGESFDLVDVLAFPLP 164 Query: 176 ANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVY 235 I+ E L + + ++ F S + P ++ Sbjct: 165 VTIVA-------------ELLGLPPMDHEQFGDWSGALVDIQMDDPT----DPALAERIA 207 Query: 236 KNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSL 295 L + AY+ + R P D + + L+ E + + + +L Sbjct: 208 DVLNPLTAYLKARCAERRAD-----PGDDLISRLVLAEVD----GRALDDEEAANFSTAL 258 Query: 296 FFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYE 355 AG TT+ L + ++P + + ++ A++ E Sbjct: 259 LLAGHITTTVLLGNIVRTLDEHPAHWDAAAEDPGRI------------------PAIVEE 300 Query: 356 IQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLD 415 + R+ P + T+ T G IP D V + +A D + PD F+P Sbjct: 301 VLRYRPPFPQ-MQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSRKSG 359 Query: 416 ANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 + F G CLG +AR E + I+ F Sbjct: 360 GAAQ-------LSFGHGVHFCLGAPLARLENRVALEEIIARF 394 >4YT3-A nrPDB Length = 410 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 70/397 (17%), Positives = 122/397 (30%), Gaps = 75/397 (18%) Query: 81 VEAIREALVDKAEAFSGRGKIAMVDPFFRGYG-------VIFANGNRWKVLRRFSVTTMR 133 E ++ L D S R + + G + ++ + R Sbjct: 49 YEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVPEKIQITESDPPDHRKRRSLLAAAFT 108 Query: 134 DFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPT-FLFQSITANIICSIVFGKRFHYQD 192 + ++ E RIQE A LI ++ G +D L + ++ Sbjct: 109 PRSL--QNWEPRIQEIADELIGQM--DGGTEIDIVASLASPLPIIVMA------------ 152 Query: 193 QEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYK----NLQEINAYIGHS 248 + + + + F FL + +V K +E Y+ Sbjct: 153 -DLMGVPSKDRLLFKKWVDTL---------FLPFDREKQEEVDKLKQVAAKEYYQYLYPI 202 Query: 249 VEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLR 308 V + R P D I + LL E + F+ + T+ + AG ETTS L Sbjct: 203 VVQKR-----LNPADDIISDLLKSEVDGEM----FTDDEVVRTTMLILGAGVETTSHLLA 253 Query: 309 YGFLLML-KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGV 367 F +L V + ++ ++ + E+ RF + + Sbjct: 254 NSFYSLLYDDKEVYQELHENLD------------------LVPQAVEEMLRFR-FNLIKL 294 Query: 368 PHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFI 427 V + G + + V + +S A D FE P N + + Sbjct: 295 DRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHRPNNKK--------HL 346 Query: 428 PFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVA 464 F G CLG +AR E + T L+ F V Sbjct: 347 TFGNGPHFCLGAPLARLEAKIALTAFLKKFKHIEAVP 383 >5L1U-A nrPDB Length = 401 Score = 147 bits (372), Expect = 7e-36, Method: Composition-based stats. Identities = 68/437 (15%), Positives = 133/437 (30%), Gaps = 75/437 (17%) Query: 60 EKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGN 119 +K G + V ++ + +R L D+ S R + V A G+ Sbjct: 28 QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALAAGD 87 Query: 120 RW----KVLRRFSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQ-S 173 + + F + R ++ RI+ L+++L + +D + Sbjct: 88 DHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQL-AASAPPVDLHRVLSFR 146 Query: 174 ITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQ 233 + ++C ++ G +++ F Q+ + Sbjct: 147 LPTMVVCDLL-GVPLADRERFGQWARGTFDQS------------------------DNEH 181 Query: 234 VYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTL 293 Q++ Y+ V + R P D I + L+ S ++ Sbjct: 182 SANTFQQVVDYMLELVARKRV-----EPGDDILSELIA------EKDGALSDADIAHLGN 230 Query: 294 SLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVI 353 ++ G ETT + G LL+L+ P ++ + A + Sbjct: 231 AVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPG------------------LAPAAV 272 Query: 354 YEIQRFSDLLPMG---VPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNP 410 EI R +P + +I V L + A +D F F+ Sbjct: 273 EEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDL 332 Query: 411 DHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF-SMASPVAPEDID 469 + + + F G R C+G +AR EL F + + + V E + Sbjct: 333 TR--------VRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLR 384 Query: 470 LTPQEC--GVGKIPPTY 484 G +IP T+ Sbjct: 385 WQEHRITGGFDEIPVTF 401 >3RWL-A nrPDB Length = 426 Score = 147 bits (372), Expect = 7e-36, Method: Composition-based stats. Identities = 59/367 (16%), Positives = 113/367 (30%), Gaps = 58/367 (15%) Query: 117 NGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITA 176 + R R+ + + ++E I+E ++ L G D Sbjct: 115 DRPRHDEQRKAVSPIVAPANLA--ALEGTIRERVSKTLDGLPV--GEEFDWVDRVSIEIT 170 Query: 177 NIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYK 236 + + +F D F + L + ++ G + E + Q Sbjct: 171 TQMLATLF-------DFPFEERRKLTRWSDVTTAAPGGGVVESW-----------DQRKT 212 Query: 237 NLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLF 296 L E AY + P + + + L H ++ + + N L L Sbjct: 213 ELLECAAYFQVLWNER----VNKDPGNDLISMLAHSPATRN-----MTPEEYLGNVLLLI 263 Query: 297 FAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEI 356 G +TT ++ G L + K P ++ A E ++ EI Sbjct: 264 VGGNDTTRNSMTGGVLALHKNPDQFAKLK------------------ANPALVETMVPEI 305 Query: 357 QRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDA 416 R+ L + + G I K +V + + D ++P+ F D Sbjct: 306 IRWQTPLA-HMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR---- 360 Query: 417 NGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECG 476 + + F G C+G +A +L + + IL FS +A + + G Sbjct: 361 ----PRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFSRIEVMAEPERVRSNFVRG 416 Query: 477 VGKIPPT 483 K+ Sbjct: 417 YAKMMVR 423 >1Q5D-A nrPDB Length = 419 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 64/373 (17%), Positives = 125/373 (33%), Gaps = 55/373 (14%) Query: 109 RGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPT 168 + YG+ +R+ + + + IQ L++ +S D Sbjct: 91 KKYGLFGLPPEDHARVRKLVNPSFTSRAI--DLLRAEIQRTVDQLLDA--RSGQEEFDVV 146 Query: 169 FLFQS-ITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYF 227 + I I +++ + + F + S + G G + Sbjct: 147 RDYAEGIPMRAISALL---------KVPAECDEKFRRFGSATARALG------VGLVPRV 191 Query: 228 PGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQN 287 + + ++ E A + +++ R ++ ++ +L M + S S + Sbjct: 192 DEETKTLVASVTEGLALLHGVLDERR--------RNPLENDVLTMLLQAEADGSRLSTKE 243 Query: 288 LNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMP 347 L ++ AGT+TT + + L +L+ P E V E Sbjct: 244 LVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAEPG------------------ 285 Query: 348 YTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDA 407 + E+ RF ++L +G Q + G I K VFL++ +AL D F +PD Sbjct: 286 LMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSALRDGTVFSRPDV 345 Query: 408 FNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPED 467 F+ + T A + + G +C G +AR E + TI + F Sbjct: 346 FD---------VRRDTSASLAYGRGPHVCPGVSLARLEAEIAVGTIFRRFPEMKLKETPV 396 Query: 468 IDLTPQECGVGKI 480 P + + Sbjct: 397 FGYHPAFRNIESL 409 >3TKT-A nrPDB Length = 450 Score = 145 bits (366), Expect = 4e-35, Method: Composition-based stats. Identities = 71/418 (16%), Positives = 130/418 (31%), Gaps = 57/418 (13%) Query: 76 VMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRG-----YGVIFANGNRWKVLRRFSVT 130 VM + K+ F+ R M G ++ + + LRR + Sbjct: 82 VMKASKDNATFLNNPKSTVFTLRVGEMMAKAITGGSPHLVESLVQMDAPKHPKLRRLTQD 141 Query: 131 TMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHY 190 + + ++ I++ A I+ + + + +++ I+ Sbjct: 142 WFMPKNLAR--LDGEIRKIANEAIDRMLGAGEEGDFMALVAAPYPLHVVMQIL---GVPP 196 Query: 191 QDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFP--GAHRQVYKNLQEINAYIGHS 248 +D+ KML L Q F GQ ++ LK P + V + E Y Sbjct: 197 EDEP--KMLFLTQQMFG------GQDEDMNKSGLKDLPPEQISQIVAGAVAEFERYFAGL 248 Query: 249 VEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLR 308 + R P D + T + + + S ++ + AG +TTS + Sbjct: 249 AAERRR-----NPTDDVATVIANAVVD----GEPMSDRDTAGYYIITASAGHDTTSASSA 299 Query: 309 YGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVP 368 L + + P + RV DR +P ++ E R++ + Sbjct: 300 GAALALARDPDLFARVKA---------------DRNLLP---GIVEEAIRWTTPVQ-HFM 340 Query: 369 HIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIP 428 T G I + L A HDP F +P F+P + Sbjct: 341 RTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR---------PANRHLA 391 Query: 429 FSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQI 486 F G CLG +AR E+ + +L + G +P ++ Sbjct: 392 FGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVGGFKSLPMRWKA 449 >5FYF-A nrPDB Length = 470 Score = 145 bits (365), Expect = 5e-35, Method: Composition-based stats. Identities = 44/256 (17%), Positives = 80/256 (31%), Gaps = 30/256 (11%) Query: 227 FPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQ 286 F + ++ +K P + + L ++ K + Sbjct: 239 FADENAMFDDAADMARSFSRLWRDKEARRAAGEEPGFDLISLLQSNKETKDLINRPM--- 295 Query: 287 NLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKM 346 N L G +TT ++ G + M ++P E++ AK Sbjct: 296 EFIGNLTLLIVGGNDTTRNSMSGGLVAMNEFPREFEKLK------------------AKP 337 Query: 347 PYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPD 406 ++ EI R+ L + I Q G I K V + ++ D F+ PD Sbjct: 338 ELIPNMVSEIIRWQTPLA-YMRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPD 396 Query: 407 AFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPE 466 F D K + F G C+G +A +L + + IL+ F V Sbjct: 397 QFIIDR--------KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFDNIEVVEEP 448 Query: 467 DIDLTPQECGVGKIPP 482 + + G ++ Sbjct: 449 ERVQSNFVRGYSRLMV 464 >5DE9-A nrPDB Length = 410 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 82/479 (17%), Positives = 143/479 (29%), Gaps = 89/479 (18%) Query: 20 VQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHL--GPRPVVM 77 + + P P + + + G V + L G + Sbjct: 1 MTEETISQAVPPVRDWP------AVDLPGSDFDPVLTELMRE-GPVTRISLPNGEGWAWL 53 Query: 78 LCGVEAIREALVDKA---EAFSGRGKIAMVDPFFRGYG-VIFANGNRWKVLRRFSVTTMR 133 + + +R D EA R + F G V F + LRR Sbjct: 54 VTRHDDVRLVTNDPRFGREAVMDRQVTRLAPHFRPARGAVGFLDPPDHTRLRRSVAAAFT 113 Query: 134 DFGMGKRSVEERIQEEAQCLIEELRKS---KGALMDPTF-LFQSITANIICSIVFGKRFH 189 G+ ER++E ++ +++EL + G D T + +IC ++ Sbjct: 114 ARGV------ERVRERSRGMLDELVDAMLRAGPPADLTEAVLSPFPIAVICELM------ 161 Query: 190 YQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSV 249 + + ++ + + E+NAY + Sbjct: 162 ------------------GVPATDRHSMHTWTQLILSSSHGAEVSERAKNEMNAYFSDLI 203 Query: 250 EKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRY 309 L + + + + L E + + L G E + Sbjct: 204 -----GLRSDSAGEDVTSLLGAAV-----GRDEITLSEAVGLAVLLQIGG-EAVTNNSGQ 252 Query: 310 GFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSD-LLPMGVP 368 F L+L P +AER+ E PE+ RA I E+ R+ +G+ Sbjct: 253 MFHLLLSRPELAERLRSE----------PEIRPRA--------IDELLRWIPHRNAVGLS 294 Query: 369 HIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIP 428 I + +G I V++ A DP F PD + + + Sbjct: 295 RIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFER---------SPNPHVS 345 Query: 429 FSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPEDIDLTPQEC--GVGKIPPTY 484 F G C G +AR E L +L + VAPED+ G +P T+ Sbjct: 346 FGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGALIRGPEALPVTW 404 >5HDI-A nrPDB Length = 404 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 70/405 (17%), Positives = 127/405 (31%), Gaps = 74/405 (18%) Query: 69 HLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYG--------------VI 114 + +CG +A+ EA + + E FS A + G + Sbjct: 34 RIANSDFYAVCGWDAVNEA-IGRPEDFSS-NLTATMTYTAEGTAKPFEMDPLGGPTHVLA 91 Query: 115 FANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSI 174 A+ V R+ +R + V E+ +A + G + + + Sbjct: 92 TADDPAHAVHRKL---VLRHLAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRL 148 Query: 175 TANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQV 234 ++ ++ D + +++ Y L+ + Sbjct: 149 PMMVVAELI-----GLPDPDIAQLVKWGYAATQLLEGLVEN-------------DQLVAA 190 Query: 235 YKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLS 294 L E++ YI ++ + P+D + L + A E + ++ Sbjct: 191 GVALMELSGYIFEQFDRA-----AADPRDNLLGEL-----ATACASGELDTLTAQVMMVT 240 Query: 295 LFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIY 354 LF AG E+T+ L ++ P + ++V RA A I Sbjct: 241 LFAAGGESTAALLGSAVWILATRPDIQQQV------------------RANPELLGAFIE 282 Query: 355 EIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFL 414 E R+ H V T+ G +P D+ + L+ A DP FE P F D Sbjct: 283 ETLRYEPPFRGHYRH-VRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAG 341 Query: 415 DANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSM 459 I F G C+G +AR E + +L S+ Sbjct: 342 GKG--------HISFGKGAHFCVGAALARLEARIVLRLLLDRTSV 378 >6HQW-A nrPDB Length = 445 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 49/312 (15%), Positives = 99/312 (31%), Gaps = 34/312 (10%) Query: 160 SKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFEL 219 + +++ + TA+++ S+ +G+RF + D+ +++ +L Sbjct: 149 TPAKMVEMEAEIRRRTASVLDSLPWGERFDWVDKVSIELTTGMLAILFGFPWADRRLLTF 208 Query: 220 FSGFLKYFPGA-HRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSN 278 +S + R++ + H ++ + P + + ++H E Sbjct: 209 WSDWAGDVELTLARELADTRFGFLGEMAHYFQRLWGARMQAPPSGDLISMMIHSEAMNH- 267 Query: 279 AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP 338 S Q N + L G +TT T+ + K+P E + R+ Sbjct: 268 ----MSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPDQRELLERDA---------- 313 Query: 339 ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHD 398 + E R+ L + T T G I +V L +A D Sbjct: 314 --------SLIPNAVQECIRYVTPLA-HMRRTATADTELFGNQIKAGEKVILWYISANRD 364 Query: 399 PHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTIL-QNF 457 FE PD D + F G C+G +A +L + + + Sbjct: 365 ETVFENPDKLMVDR--------PNARRHLSFGHGIHRCVGARLAELQLRILLEEMHERRM 416 Query: 458 SMASPVAPEDID 469 + E + Sbjct: 417 RVRVAGEVERVR 428 >5DQN-A nrPDB Length = 426 Score = 142 bits (358), Expect = 3e-34, Method: Composition-based stats. Identities = 47/247 (19%), Positives = 76/247 (30%), Gaps = 40/247 (16%) Query: 240 EINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAG 299 E+ +Y E+ P + I T L+ + + S + L AG Sbjct: 202 ELISYAMKMAEER-----AVNPTEDIVTKLIEADIDGEK----LSDDEFGFFVVMLAVAG 252 Query: 300 TETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRF 359 ETT ++ +G + + P E +E E EI R+ Sbjct: 253 NETTRNSITHGMIAFAQNPDQWELYKKE--------------------RPETAADEIVRW 292 Query: 360 SDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGA 419 + + + G I K V + +A D FE P FN Sbjct: 293 ATPV-SAFQRTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNI--------- 342 Query: 420 LKKTEAFIPFSL-GKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVG 478 L+ + F G C+G +AR + L F I N P+ + + G+ Sbjct: 343 LRSPNPHVGFGGTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAPERLKSGWLNGIK 402 Query: 479 KIPPTYQ 485 Y Sbjct: 403 HWQVDYT 409 >2FR7-A nrPDB Length = 412 Score = 141 bits (356), Expect = 5e-34, Method: Composition-based stats. Identities = 37/203 (18%), Positives = 66/203 (32%), Gaps = 28/203 (13%) Query: 279 AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP 338 E + + L SL AG +TT + + ++P R+ Sbjct: 232 DTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARL-------------- 277 Query: 339 ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHD 398 RA E RF + T+ G I + +V + L +A D Sbjct: 278 ----RADPSLARNAFEEAVRFESPVQ-TFFRTTTRDVELAGATIGEGEKVLMFLGSANRD 332 Query: 399 PHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 458 P ++ PD ++ KT + F G +C+G+ +AR E + + + + Sbjct: 333 PRRWDDPDRYDITR---------KTSGHVGFGSGVHMCVGQLVARLEGEVVLAALARKVA 383 Query: 459 MASPVAPEDIDLTPQECGVGKIP 481 P G+ +P Sbjct: 384 AIEIAGPLKRRFNNTLRGLESLP 406 >1WIY-A nrPDB Length = 389 Score = 141 bits (354), Expect = 9e-34, Method: Composition-based stats. Identities = 79/432 (18%), Positives = 136/432 (31%), Gaps = 79/432 (18%) Query: 37 LPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFS 96 P L +L ++ L L + + +F + L P+ ++ E + AL+ + + Sbjct: 10 WPYLKDL----QQDPLAVLLEWGRAHPRLF-LPLPRFPLALIFDPEGVEGALLAEGTTKA 64 Query: 97 GRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEE 156 A+ G G++ G WK R+ + R E ++EEA E Sbjct: 65 TFQYRALSRL--TGRGLLTDWGKSWKEARKALKDPFLPKSV--RGYREAMEEEAWAFFGE 120 Query: 157 LRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQL 216 R G D +++ ++ +FGK Sbjct: 121 WR---GEERDLDHEMLALSLRLLGRALFGK------------------------------ 147 Query: 217 FELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEK 276 P K L I + + + + D L+ E E Sbjct: 148 --------PLSPSLAEHALKALDRI---MAQTRSPLALLDLAAEARFRKDRGALYREAEA 196 Query: 277 SNAHSEFSH---QNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIG 333 H SH + ++L AG ET ++ L + FLL+ P +RV E + Sbjct: 197 LIVHPPLSHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALA 256 Query: 334 PHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILS 393 E R + + + +P+ T + L Sbjct: 257 A------------------FQEALRLYPPAWILTRR-LERPLLLGEDRLPQGTTLVLSPY 297 Query: 394 TALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTI 453 YF + +AF P+ FL G + + PF LG+R+CLG A E + Sbjct: 298 VTQR--LYFPEGEAFQPERFLAERGT--PSGRYFPFGLGQRLCLGRDFALLEGPIVLRAF 353 Query: 454 LQNFSMASPVAP 465 + F + P Sbjct: 354 FRRFRLDPLPFP 365 >4DO1-A nrPDB Length = 410 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 36/204 (17%), Positives = 67/204 (32%), Gaps = 28/204 (13%) Query: 279 AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP 338 E + L SL AG +TT + + ++P +R+ Sbjct: 230 DTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRL-------------- 275 Query: 339 ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHD 398 R+ E RF + T+ G +I + +V + L +A D Sbjct: 276 ----RSDPTLARNAFEEAVRFESPVQ-TFFRTTTREVELGGAVIGEGEKVLMFLGSANRD 330 Query: 399 PHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 458 P + PD ++ KT + F G +C+G+ +AR E + + + + + Sbjct: 331 PRRWSDPDLYDITR---------KTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVA 381 Query: 459 MASPVAPEDIDLTPQECGVGKIPP 482 P G+ +P Sbjct: 382 AIDIDGPVKRRFNNTLRGLESLPV 405 >1F4U-A nrPDB Length = 368 Score = 137 bits (346), Expect = 8e-33, Method: Composition-based stats. Identities = 56/348 (16%), Positives = 109/348 (31%), Gaps = 74/348 (21%) Query: 111 YGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFL 170 Y ++ ++ LR S + +++E I+E + L++ + + ++ L Sbjct: 66 YTMLTSDPPLHDELRSMSADIFSPQKL--QTLETFIRETTRSLLDSIDPREDDIV--KKL 121 Query: 171 FQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGA 230 + +I I+ +D+E F + L++ G+ E+F KY Sbjct: 122 AVPLPIIVISKIL---GLPIEDKE------KFKEWSDLVAFRLGKPGEIFELGKKYL--- 169 Query: 231 HRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNL 290 E+ Y+ D E +S S Sbjct: 170 ---------ELIGYVK-------------------DHLNSGTEVVSRVVNSNLSDIEKLG 201 Query: 291 NTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTE 350 + L AG ETT+ + + ++ ++ +R+ E Sbjct: 202 YIILLLIAGNETTTNLISNSVIDFTRF-NLWQRIREE-------------------NLYL 241 Query: 351 AVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNP 410 I E R+S + M + I + V + +++A D F + F P Sbjct: 242 KAIEEALRYSPPV-MRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIP 300 Query: 411 DHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 458 D + F G +CLG +AR E + + F Sbjct: 301 DR---------NPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFR 339 >2RFC-A nrPDB Length = 343 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 46/298 (15%), Positives = 91/298 (30%), Gaps = 48/298 (16%) Query: 161 KGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELF 220 + D + + ++I K +D + L S I + LF Sbjct: 68 PSKINDYKDFIEETSNDLI------KNIDNKDIISEYAVRLPVNIISKILGIPDSDMPLF 121 Query: 221 SGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAH 280 + Y G R + N V + E + ++++ S + Sbjct: 122 KLWSDYIIGNKRD-----ENFNYVNNRMVSRLLEIFKSDSHG------IINVLAGSSLKN 170 Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 + + + L G ETT+ + ++ + P + + + Sbjct: 171 RKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDIIDDALKNR------------ 218 Query: 341 HDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPH 400 + E R+ + + + I K +V + L +A D Sbjct: 219 ---------SGFVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDET 269 Query: 401 YFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 458 +F++PD F E + F +G +CLG +AR E + IL +F Sbjct: 270 FFDEPDLFKIGRR----------EMHLAFGIGIHMCLGAPLARLEASIALNDILNHFK 317 >1UE8-A nrPDB Length = 367 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 56/319 (17%), Positives = 101/319 (31%), Gaps = 45/319 (14%) Query: 153 LIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSV 212 L +ELR +P+ L + ++ D+EF + + L+ S Sbjct: 75 LHDELRNLTADAFNPSNLPVDFVREVTVKLL-----SELDEEFDVIESFAIPLPILVISK 129 Query: 213 FGQLFELFSGFLKYFPGAHRQVYKNLQ--EINAYIGHSVEKHRETLDPSAPKDLIDTYLL 270 + + ++ + + I + ++ LD K+++D Sbjct: 130 MLGINPDVKKVKDWSDLVALRLGRADEIFSIGRKYLELISFSKKELDSRKGKEIVD---- 185 Query: 271 HMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQ 330 A+S S + L AG ETT+ + E Sbjct: 186 ---LTGKIANSNLSELEKEGYFILLMIAGNETTTNLIGNAI---------------EDFT 227 Query: 331 VIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFL 390 + K + E RFS + M + + R +I + V + Sbjct: 228 LYNSWDYVREKGALK------AVEEALRFSPPV-MRTIRVTKEKVKIRDQVIDEGELVRV 280 Query: 391 ILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFF 450 +++A D F+ PD+F PD + F G +CLG +AR E + Sbjct: 281 WIASANRDEEVFKDPDSFIPDR---------TPNPHLSFGSGIHLCLGAPLARLEARIAL 331 Query: 451 TTILQNFSMASPVAPEDID 469 + F + V E ID Sbjct: 332 EEFAKKFRVKEIVKKEKID 350 >3IVY-A nrPDB Length = 433 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 48/259 (18%), Positives = 83/259 (32%), Gaps = 40/259 (15%) Query: 230 AHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLN 289 AH + E+ Y E+ P D I T L+ + + S Sbjct: 209 AHIDPKASSAELIGYAMKMAEEK-----AKNPADDIVTQLIQADIDGEK----LSDDEFG 259 Query: 290 LNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYT 349 + L AG ETT ++ G + ++P E +Y+++ Sbjct: 260 FFVVMLAVAGNETTRNSITQGMMAFAEHPDQWE-LYKKV-------------------RP 299 Query: 350 EAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFN 409 E EI R++ + + G I K V + +A D F+ P FN Sbjct: 300 ETAADEIVRWATPV-TAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFN 358 Query: 410 PDHFLDANGALKKTEAFIPFSL-GKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDI 468 L+ + F G C+G +AR + L F + + P++ + Sbjct: 359 I---------LRNPNPHVGFGGTGAHYCIGANLARMTINLIFNAVADHMPDLKPISAPER 409 Query: 469 DLTPQECGVGKIPPTYQIR 487 + G+ Y R Sbjct: 410 LRSGWLNGIKHWQVDYTGR 428 >4PWV-A nrPDB Length = 446 Score = 136 bits (342), Expect = 3e-32, Method: Composition-based stats. Identities = 64/409 (15%), Positives = 121/409 (29%), Gaps = 76/409 (18%) Query: 87 ALVDKAEAFSGRGKIAMVDPFFRGYG-----VIFANGNRWKVLRRFSVTTMRDFGMGKRS 141 AL + + +V G + +G + LR + + ++ Sbjct: 87 ALYKDNKKLTSEKGNVLVTLLAGGDSAAGKMLAVTDGAMHRGLRNVLLKSFSP-----QA 141 Query: 142 VEERIQEE----AQCLIEELRKSKGALMDPTFLFQS-ITANIICSIVFGKRFHYQDQEFL 196 ++ + + + +++ R+ D I N I ++ D+EFL Sbjct: 142 LKPIVDQIRVNTTRLVVDAARR---GECDFAADVAEQIPLNTISDLL---GVPAADREFL 195 Query: 197 KMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL 256 LN S +SS + + + EI Y V + R Sbjct: 196 LKLNK-----SALSS-------------EDADQSATDAWLARNEILLYFSELVAERRAK- 236 Query: 257 DPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLK 316 P + + + L + + + + + LN SL G ET+ ++ + Sbjct: 237 ----PTEDVISVLANSMVD----GKPLTEEVIVLNCYSLILGGDETSRLSMIDSVQTFTQ 288 Query: 317 YPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTS 376 YP E + E+ E+ R++ M Sbjct: 289 YPDQWELLRDGKVT------------------LESATEEVLRWATPA-MHFGRRAVTDME 329 Query: 377 FRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRIC 436 G +I V L ++A D F P AF+ + I F G C Sbjct: 330 LHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNR---------SPNKHITFGYGPHFC 380 Query: 437 LGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQ 485 LG + RAE+ + + + G+ ++P Q Sbjct: 381 LGAYLGRAEVHALLDALRTYTTGFEITGEPQRIHSNFLTGLSRLPVRIQ 429 >5HH3-A nrPDB Length = 397 Score = 136 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 62/418 (14%), Positives = 113/418 (27%), Gaps = 74/418 (17%) Query: 71 GPRPVVMLCGVEAIREALVDKAEAFSGRGKI--AMVDPFFRGYGVIFANGNRWKVLRRFS 128 G R + G + IR+ L + FS R + G+ + LRR Sbjct: 50 GGRTAWLATGYDEIRQVLSS--DDFSARLLYGGTAAGITWPGFLTQYD-PPEHTRLRRMV 106 Query: 129 VTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRF 188 M K + +++ Q ++ + G +D F + + F Sbjct: 107 APAFAVRRMQK--FQPQVERVVQDSLDAIEAL-GGPVDFVPRFG-WSVATTATCDFLGIP 162 Query: 189 HYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHS 248 + + L+ + ++ + Y+ Sbjct: 163 RDDQADLARSLH-----------------------ASRTERSGKRRTAAGNKFMTYMNKM 199 Query: 249 VEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLR 308 + R +D D + +E + E + L + AG + + L Sbjct: 200 TARTR--------RDPGDDMFGVVVREYGD---EITDAELTGVAAFVMGAGADQVARFLA 248 Query: 309 YGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVP 368 G LM P + + + V P+ D E+ R+ P Sbjct: 249 AGAWLMADDPEQFALLREKPDTV------PDWLD------------EVIRYLTTDEKTHP 290 Query: 369 HIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKP-DAFNPDHFLDANGALKKTEAFI 427 + T ++I V L A F +P D F+ + Sbjct: 291 RVATDDVRIGDHLIKAGDTVTCSLLAANR--RNFPRPEDRFDITRVRPE---------HL 339 Query: 428 PFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAP-EDIDLTPQECGVGKIPPTY 484 F G CLG +A + F P +I L P V + + Sbjct: 340 AFGHGIHHCLGRSLAELVFRTAIPALAHRFPTLRLAEPHREIRLGPPPFDVEALLLDW 397 >3OO3-A nrPDB Length = 384 Score = 132 bits (332), Expect = 4e-31, Method: Composition-based stats. Identities = 64/418 (15%), Positives = 121/418 (28%), Gaps = 76/418 (18%) Query: 72 PRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTT 131 R ++ G + +R L D S R D + + LRR Sbjct: 38 GRKQWLVTGHDEVRAILADHERFSSMRPVDDEADRALLPGILQAYDPPDHTRLRRTVAPA 97 Query: 132 MRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMD-PTFLFQSITANIICSIVFGKRFHY 190 M + RI+E + +++ +S GA +D I A I C + R Sbjct: 98 YSARRM--ERLRPRIEEIVEECLDDF-ESVGAPVDFVRHAAWPIPAYIACEFLGVPR--D 152 Query: 191 QDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVE 250 E +M+ R+ Q + +G + Sbjct: 153 DQAELSRMIRE-----------------------------SRESRLPRQRTLSGLG--IV 181 Query: 251 KHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYG 310 + + L +D D + + +E +E S + L E + L Sbjct: 182 NYTKRLTSGKRRDPGDGMIGVIVREH---GAEISDEELAGLAEGNLIMAAEQMAAQLAVA 238 Query: 311 FLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHI 370 LL++ +P + K ++ E+ R + ++ P + Sbjct: 239 VLLLVTHPDQMALLRE------------------KPELIDSATEEVLRHASIVEAPAPRV 280 Query: 371 VTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFS 430 G I + + P D F+ + + F Sbjct: 281 ALADVRMAGRDIHAGDVLTCSMLATNRAP-----GDRFDITR---------EKATHMAFG 326 Query: 431 LGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPEDIDLTPQE---CGVGKIPPTY 484 G C+G +AR +L + ++ F + V ED+ P V ++P + Sbjct: 327 HGIHHCIGAPLARLQLRVALPAVVGRFPSLRLAVPEEDLRFKPGRPAPFAVEELPLEW 384 >5LIV-A nrPDB Length = 450 Score = 131 bits (330), Expect = 6e-31, Method: Composition-based stats. Identities = 64/381 (16%), Positives = 113/381 (29%), Gaps = 68/381 (17%) Query: 98 RGKIAMVDPFFR----GYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCL 153 R F+ G+ G+ +RR + + E ++ ++ + Sbjct: 104 RDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAV-SQYEERFVRPISEQV 162 Query: 154 IEELRKSKGALMDPTFLFQ-SITANIICSIVFG---KRFHYQDQEFLKMLNLFYQTFSLI 209 ++ L +D F + +I +FG ++ H D+ ML + Sbjct: 163 VDRLAGKP--RVDLLEDFAMELPRRVIGE-LFGFPAEKLHETDERVRAMLRGLVRMHD-- 217 Query: 210 SSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYL 269 P A + + E I VE+ +D DT L Sbjct: 218 ------------------PAAVAESQRAYGETLGLITEVVERES--------RDTSDTLL 251 Query: 270 LHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIE 329 + + H + + + LSL G ETTS + +L +P RV ++ Sbjct: 252 GEILRTLKAEHMD-TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQD-- 308 Query: 330 QVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVF 389 A I E R+ GV +V + + T V Sbjct: 309 ----------------PSLLPAAIEEGMRWCPSS-FGVLRMVERDVRLDDQALSAGTVVC 351 Query: 390 LILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLF 449 L +D + P+ ++ D + F G C+G +AR E + Sbjct: 352 LAGIAGNYDETAYPSPEVYDIDRKPLPAANV--------FGGGAHFCVGAPLARMEARVG 403 Query: 450 FTTILQNFSMASPVAPEDIDL 470 +L F V E Sbjct: 404 LQALLARFPGLRAVPEERPSF 424 >6F88-A nrPDB Length = 400 Score = 130 bits (328), Expect = 9e-31, Method: Composition-based stats. Identities = 64/381 (16%), Positives = 113/381 (29%), Gaps = 68/381 (17%) Query: 98 RGKIAMVDPFFR----GYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCL 153 R F+ G+ G+ +RR + + E ++ ++ + Sbjct: 54 RDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAV-SQYEERFVRPISEQV 112 Query: 154 IEELRKSKGALMDPTFLFQ-SITANIICSIVFG---KRFHYQDQEFLKMLNLFYQTFSLI 209 ++ L +D F + +I +FG ++ H D+ ML + Sbjct: 113 VDRLAGKP--RVDLLEDFAMELPRRVIGE-LFGFPAEKLHETDERVRAMLRGLVRMHD-- 167 Query: 210 SSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYL 269 P A + + E I VE+ +D DT L Sbjct: 168 ------------------PAAVAESQRAYGETLGLITEVVERES--------RDTSDTLL 201 Query: 270 LHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIE 329 + + H + + + LSL G ETTS + +L +P RV ++ Sbjct: 202 GEILRTLKAEHMD-TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQD-- 258 Query: 330 QVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVF 389 A I E R+ GV +V + + T V Sbjct: 259 ----------------PSLLPAAIEEGMRWCPSN-FGVLRMVERDVRLDDQALSAGTVVC 301 Query: 390 LILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLF 449 L +D + P+ ++ D + F G C+G +AR E + Sbjct: 302 LAGIAGNYDETAYPSPEVYDIDRKPLPAANV--------FGGGAHFCVGAPLARMEARVG 353 Query: 450 FTTILQNFSMASPVAPEDIDL 470 +L F V E Sbjct: 354 LQALLARFPGLRAVPEERPSF 374 >6GII-A nrPDB Length = 479 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 59/421 (14%), Positives = 129/421 (30%), Gaps = 73/421 (17%) Query: 52 LKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMV------- 104 F+R+ + +F + ++ + I++ FS + Sbjct: 80 PAQFVRWAREQVPIF--YAPKLNYWVVTRYDTIKQIF-RDPVTFSPSNVLQSFAQPSAEV 136 Query: 105 DPFFRGYGVIFA------NGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELR 158 YG F + RR + + + E ++E + + Sbjct: 137 RQVLERYGYAFNRTLVNEDEPMHLERRRVLMEPFASEHLAEH--EPMVRELVRRAVNRFI 194 Query: 159 KS-KGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLF 217 + + L+D + + + F D + + + F + Sbjct: 195 DTGRADLVD--QMIWEVPFTVAL------HFLGVDDDDREKMRRF------------AIA 234 Query: 218 ELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKS 277 + F + P V + + + + G +EK R T D + + +++ Sbjct: 235 HTVNAFGRPSPEEQLAVAETVGQFWQFCGEVLEKMRRTADGPGW-------MRYSIRQQK 287 Query: 278 NAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRP 337 + L+ ++ A ETT +L++ E V+REI Sbjct: 288 LYPDVVTDSYLHSMMQAIIVAAHETTVFATTNALKTLLEH----ETVWREI--------- 334 Query: 338 PELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALH 397 A A E R++ + G T+ G +P + +++++A H Sbjct: 335 -----CADPSLIPAAAEECLRYNGPVA-GWRRRTTREVEVEGVRLPVGANILMVVASANH 388 Query: 398 DPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 D +F+ P+ F+ + F G CLG + R E+ + + + Sbjct: 389 DSAHFDDPEFFDIGR--------SNASEHLNFGYGAHQCLGRNLGRMEMQIMIEELSRRL 440 Query: 458 S 458 Sbjct: 441 P 441 >2X9P-A nrPDB Length = 404 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 63/441 (14%), Positives = 127/441 (28%), Gaps = 78/441 (17%) Query: 55 FLRFREKYGDVFTVHL-GPRPVVMLCGVEAIREALVDK--AEAFSGRGKIAMVDPF-FRG 110 LR + G + V ++ +++ L D+ A F Sbjct: 31 LLRALQDRGPIHRVRTPAGDEAWLVTRHAELKQLLHDERIGRTHPDPPSAAQYVRSPFLD 90 Query: 111 YGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVE--ERIQEEAQCLIEELRKSKGALMDPT 168 + A+ + + + +R +E +++E A L++ ++G D Sbjct: 91 LLISDADAESGRRQHAETRRLLTPLFSARRVLEMQPKVEEAADTLLDAF-IAQGPPGDLH 149 Query: 169 FLFQ-SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYF 227 ++C ++ Q ++ L L Sbjct: 150 GELTVPFALTVLCEVI-----GVPPQRRAELTTLLAGIAKL------------------- 185 Query: 228 PGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQN 287 + ++ Y+ VE R P D+I E + Sbjct: 186 -DDREGAVRAQDDLFGYVAGLVEHKRAEPGP----DIISRL----------NDGELTEDR 230 Query: 288 LNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMP 347 + + L FAG ++ ++ + G +L+ +P + + Sbjct: 231 VAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPD------------------ 272 Query: 348 YTEAVIYEIQRFSDLL-PMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPD 406 + E+ R + + P ++ F G I V L D F P+ Sbjct: 273 VMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGPE 332 Query: 407 AFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAP- 465 F+ A + + F G C+G +AR EL FT + P P Sbjct: 333 EFD---------AARTPNPHLTFGHGIWHCIGAPLARLELRTMFTKLFTRLPELRPELPV 383 Query: 466 EDIDLTPQEC--GVGKIPPTY 484 E + L + G ++ + Sbjct: 384 EQLRLKEGQLSGGFAELRVVW 404 >5HIW-A nrPDB Length = 398 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 65/408 (15%), Positives = 123/408 (30%), Gaps = 65/408 (15%) Query: 76 VMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDF 135 V+L G + + A++ +E FS R D ++ G +RR + Sbjct: 41 VVLRGADVV--AVLRDSETFSTR----TYDTGIMKGALVTLGGEAHTRMRRLFNAVLSP- 93 Query: 136 GMGKRSVEERIQEEAQCLIEEL-RKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQE 194 + R E + A+ ++E L RK + L D + + + +R D Sbjct: 94 RVISRYEEATVTPVARRVVERLVRKERAELFDDFAISMPMGVTSALFGLPEERIAENDAL 153 Query: 195 FLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRE 254 KM+ S + P + + A + E+ Sbjct: 154 IRKMIR--------------------SVVMPQDPVVVAEGRSAHAAMEAQLREIAERE-- 191 Query: 255 TLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM 314 + P D + + + E L+L ETTS L + + Sbjct: 192 ---VAHPSDTLLGEIARAIVAEGLGGVEACE----GVVLTLILGSYETTSWMLANLLVAL 244 Query: 315 LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH 374 L +P ++ R + I E R+ G+ V + Sbjct: 245 LAHPDAMNQL------------------RQQPSLLPQAIEESTRWCSSAA-GIVRFVERE 285 Query: 375 TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR 434 + G + T ++L L +D + +P+ F+ + + F G Sbjct: 286 ATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHR---------RPVGMLNFGGGLH 336 Query: 435 ICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPP 482 C+G +AR E + + +L+ F + G P Sbjct: 337 YCVGAPLARMEARVGVSLLLERFPALRADPTVQPTFSTAPRGAAAFGP 384 >5H1Z-A nrPDB Length = 407 Score = 129 bits (323), Expect = 4e-30, Method: Composition-based stats. Identities = 54/411 (13%), Positives = 116/411 (28%), Gaps = 64/411 (15%) Query: 59 REKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANG 118 +G ++V + + + A F + P F I + Sbjct: 42 HSDFGPYWSVSSYKPIITVESLPDLYSSAGGITLADFIENNPTDVRMPMF-----IAMDR 96 Query: 119 NRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANI 178 + RR M + + + I+ +++ L D Sbjct: 97 PKHTGQRRTVAPAFTPSEMVR--MSDNIRMRTAEVLDSLEW--NTPFDWVDTVSVELTTQ 152 Query: 179 ICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL 238 + +I+F F ++++ L + + L+ + + +++ Sbjct: 153 MLAILF--DFPWEERRKLTFWSDWAGDIELVKN----------------EELRLERLRHM 194 Query: 239 QEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFA 298 E Y + P + + ++H S+A +E N + L Sbjct: 195 YECGGYFQNLWNAK----IGKPPTPDLISMMIH-----SDAMAEMDQMEFLGNLILLIVG 245 Query: 299 GTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQR 358 G +TT T+ + +P ++ A + EI R Sbjct: 246 GNDTTRNTMSAVAYGLDLFPDQRAKL------------------EADPSMIPNTVQEIIR 287 Query: 359 FSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANG 418 + L + T + G I ++ L +A D FE D D Sbjct: 288 WQTPLA-HMRRTATVDSELEGQQIKAGDKLALWYISANRDESVFENADRIIVDR------ 340 Query: 419 ALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTIL-QNFSMASPVAPEDI 468 + F G C+G +A ++ + + + + PE + Sbjct: 341 --PNARRHLAFGHGIHRCVGARLAELQIAVLLEEMAKRRMRVNVLGEPERV 389 >6HQD-A nrPDB Length = 420 Score = 128 bits (321), Expect = 6e-30, Method: Composition-based stats. Identities = 69/453 (15%), Positives = 134/453 (29%), Gaps = 79/453 (17%) Query: 46 MDRRGLLKSFLRFREK----------YGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAF 95 +R GL F R R + YG +++ +V + + + Sbjct: 29 FERDGLHPYFERLRREDPVHYCKASEYGPYWSITKFS-DIVAIDTNHKVFSSDHTNGSFV 87 Query: 96 SGRGKIAMVD-----PFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEA 150 + VD P F G + + V R + + + E I+E Sbjct: 88 LDDTTLNAVDGGIYLPNFLG-----MDPPKHDVHRMVVSPIVAPQNLLR--FEATIRERT 140 Query: 151 QCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLIS 210 + ++ EL + + T + + F + D+ L + + + Sbjct: 141 KRVLSELPIGEEFNWVDRVSIELTTMMLATLL----DFPFDDRRKLTRWSD-----IITT 191 Query: 211 SVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLL 270 L + + Q L E AY + + PK + + L Sbjct: 192 RPGYGLVDSW-----------EQRESELMECLAYFQRLYAERQAM----PPKPDLISMLA 236 Query: 271 HMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQ 330 H S + + + L G +TT +++ + YP ++V Sbjct: 237 H-----SPEMQDLTPTDFLGTLALLIVGGNDTTRSSMSGSAMACHLYPQEFDKV------ 285 Query: 331 VIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFL 390 R +VI E+ R+ + + + FRG I K +V + Sbjct: 286 ------------RNNRALLASVIPEVVRWQTPIA-HMRRTALEDVEFRGKQIRKGDKVVM 332 Query: 391 ILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFF 450 + D ++P F D + + F G CLG +A +L + + Sbjct: 333 WYLSGNRDDEVIDRPMDFIADRP--------RARHHLSFGFGIHRCLGNRLAELQLKILW 384 Query: 451 TTILQNFSMASPVAPEDIDLTPQECGVGKIPPT 483 + + +S + G IP Sbjct: 385 EEMCERYSRIEVCGEPVRVPSNLVHGYIDIPVR 417 >6DCD-A nrPDB Length = 424 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 42/220 (19%), Positives = 67/220 (30%), Gaps = 35/220 (15%) Query: 238 LQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFF 297 LQ ++ +E R P++ + L + S ++ + LF Sbjct: 200 LQWLDDKFSAYIEDRRR-----QPRNDV---LTALATATYPDGSTPEVIDVVRSATFLFA 251 Query: 298 AGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQ 357 AG ETT+ L ++ P + R+ I E Sbjct: 252 AGQETTAKLLTAAMRVLGDRPDIQRRLRE------------------NRSLIPNFIEESL 293 Query: 358 RFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDAN 417 R + + + T+ G I T V ++ A DP FE P F D Sbjct: 294 RMDSPV-KSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR----- 347 Query: 418 GALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457 + F+ G C G +AR E + IL Sbjct: 348 ---PNVREHMAFARGVHSCPGGPLARVEGRVSLERILDRM 384 >2NZA-A nrPDB Length = 413 Score = 125 bits (313), Expect = 5e-29, Method: Composition-based stats. Identities = 70/477 (14%), Positives = 138/477 (28%), Gaps = 81/477 (16%) Query: 19 LVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHL--GPRPVV 76 + Q + PP R P L +D + G + V L G Sbjct: 1 MTQETTTLTGQSPPPVRDWP----ALDLDGPEFDPVLAELMRE-GPLTRVRLPHGEGWAW 55 Query: 77 MLCGVEAIREALVDK--AEAFSGRGKIAMVDPFFRGY--GVIFANGNRWKVLRRFSVTTM 132 + + ++ D A + +I + P F+ + FA+ LRR +V Sbjct: 56 LATRYDDVKAITNDPRFGRAEVTQRQITRLAPHFKPRPGSLAFADQPDHNRLRR-AVAGA 114 Query: 133 RDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTF-LFQSITANIICSIVFGKRFHYQ 191 G KR + R QE L++ + ++G D + + ++ ++ Sbjct: 115 FTVGATKR-LRPRAQEILDGLVDGIL-AEGPPADLVERVLEPFPIAVVSEVM---GVPAA 169 Query: 192 DQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEK 251 D+E + ++ + G + + + +I +V Sbjct: 170 DRERVH---------------------SWTRQIISTSGGAEAAERAKRGLYGWITETVRA 208 Query: 252 HRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGF 311 + ++ + E L G E + + Sbjct: 209 RAGSEGGD----------VYSMLGAAVGRGEVGETEAVGLAGPLQIGG-EAVTHNVGQML 257 Query: 312 LLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSD-LLPMGVPHI 370 L+L + R+ + + E+ R+ +G+ I Sbjct: 258 YLLLTRRELMARMRE------------------RPGARGTALDELLRWISHRTSVGLARI 299 Query: 371 VTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFS 430 + G I V++ A DP F PD + D + + Sbjct: 300 ALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDR---------DPNPHLAYG 350 Query: 431 LGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPEDIDLTPQEC--GVGKIPPTY 484 G C G +AR + L T+L+ + V E + + G +P T+ Sbjct: 351 NGHHFCTGAVLARMQTELLVDTLLERLPGLRLAVPAEQVAWRRKTMIRGPRTLPCTW 407 >6FYJ-A nrPDB Length = 421 Score = 124 bits (312), Expect = 8e-29, Method: Composition-based stats. Identities = 76/451 (16%), Positives = 156/451 (34%), Gaps = 66/451 (14%) Query: 40 LGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRG 99 + + ++ G + R D+F L + + + G EA E D E F + Sbjct: 15 IDSTWRLMEEGYMYILNRRHSFNSDIFETRLLGKKAICMGGKEAA-EIFYDT-EKFKRKD 72 Query: 100 KIA--MVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEEL 157 +V F GV +G K + ++ M + K + + +++ + +++ Sbjct: 73 AAPNRVVQTLFGKNGVQALDGQTHKHRKEMFMSIMSPDELEK--LTDITKKQWEIAVDKW 130 Query: 158 RKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLF 217 + + + I C Q+ E ++ F ++V Sbjct: 131 EQMDKVI--LYEEAKEIMCRTACQ---WAGVPVQENEVKRLTKNLGAMFESAAAVG---- 181 Query: 218 ELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKS 277 LK++ G H + Y+ + +I +++ R + P++ T L + Sbjct: 182 ------LKHWLGRHARNYEEI-----WIEELIDRVR-DGKVNPPEN---TTLHKFSWYRD 226 Query: 278 NAHSEFSHQNLNLNTLSLF---FAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP 334 + + + +++ A + + + L + YP E++ Sbjct: 227 LEGNLLDTETAAVEVINILRPIVA----IAIFINFIALALHHYPEEKEKLKS-------- 274 Query: 335 HRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILST 394 Y++ + E++RF P V +V + +++GY + T L L Sbjct: 275 ---------GDKKYSQMFVQEVRRFYPFFPFVVA-LVKKDFTWKGYKFEEGTLTLLDLYG 324 Query: 395 ALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGK----RICLGEGIARAELFLFF 450 HDP ++ PD F+PD F G+ +FIP G C GE + + + Sbjct: 325 TNHDPEIWKNPDVFSPDRFAKWEGS---PFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSL 381 Query: 451 TTILQNFSMASPVAPEDIDLTPQECGVGKIP 481 + P D DL+ + IP Sbjct: 382 DYLTNRMDYEVP----DQDLSFSMASMPSIP 408 >2UUQ-A nrPDB Length = 414 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 48/347 (13%), Positives = 102/347 (29%), Gaps = 60/347 (17%) Query: 113 VIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQ 172 ++ + R+ + +VE +++ +E+LR + G + T LF+ Sbjct: 96 MVMQDPPVHTEFRKLVSRGFTPRQV--ETVEPTVRKFVVERLEKLRANGGGDI-VTELFK 152 Query: 173 SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHR 232 + + ++ +L + + F + GA Sbjct: 153 PLPSMVVA-------------HYLGVPEEDWTQFDGWTQAIVAA--------NAVDGATT 191 Query: 233 QVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNT 292 + + AY +E+ R D I + + S + T Sbjct: 192 GALDAVGSMMAYFTGLIERRR----TEPADDAISHLVAAGVGADGDTAGTLS---ILAFT 244 Query: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 352 ++ G +T + L L+ + P + + E + Sbjct: 245 FTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGIPD------------------A 286 Query: 353 IYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYF-EKPDAFNPD 411 + E+ R + + G+ T+ + IP V L+ +A D + + Sbjct: 287 VEELLRLTSPVQ-GLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELD-- 343 Query: 412 HFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 458 + + FS G CLG AR + + T +L Sbjct: 344 -------VTRCPRNILTFSHGAHHCLGAAAARMQCRVALTELLARCP 383 >5EX8-A nrPDB Length = 424 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 64/416 (15%), Positives = 115/416 (27%), Gaps = 72/416 (17%) Query: 72 PRPVVMLCGVEAIREALVDKAEAFSGRGKI--AMVDPFFRGYGVIFANGNRWKVLRRFSV 129 R + G++ +R+ L FS R + G+ + LRR V Sbjct: 78 GRTAWLATGIDEVRQVLGSDK--FSARLLYGGTAAGITWPGFLTQYD-PPEHTRLRRMVV 134 Query: 130 TTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFH 189 M K R+++ Q ++ + S G +D F + F Sbjct: 135 PAFSHRRMQK--FRPRVEQIVQDSLDTIE-SLGGPVDFVPHFG-WAIATPATCDFLGIPR 190 Query: 190 YQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSV 249 + ++L + ++ + Y+ V Sbjct: 191 DDQADLARIL-----------------------LASRTDRSDKRRTAAGNKFMTYMKQHV 227 Query: 250 EKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRY 309 + R D + +E +A + L + A + + L Sbjct: 228 AQSRRGS--------GDDLFGIVGRENGDA---ITDAELTGVAAFVMGAAADQVARLLAA 276 Query: 310 GFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPH 369 G LM++ P + + E V PE D E R+ P Sbjct: 277 GAWLMVEQPAQFALLREKPETV------PEWLD------------ETMRYLTTDEKTHPR 318 Query: 370 IVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPF 429 + TQ ++ V L A P+Y D F+ + + F Sbjct: 319 VATQDVRIGNQLVKAGDTVTCSLLAANR-PNYPSAEDEFDITR---------EKAEHLAF 368 Query: 430 SLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPE-DIDLTPQECGVGKIPPTY 484 G CLG +A + + F P+ +I L P V + + Sbjct: 369 GHGIHHCLGRAMAELMFKVSIPALAHRFPTLRLADPQREITLGPPPFDVEALLLDW 424 >6G71-A nrPDB Length = 405 Score = 121 bits (303), Expect = 8e-28, Method: Composition-based stats. Identities = 76/447 (17%), Positives = 145/447 (32%), Gaps = 67/447 (14%) Query: 42 NLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKI 101 +L + + F R R + V V R ++ + A VD+ FS K Sbjct: 15 HLADLYQNPFP-IFERLRSE-SPVAWVPEAGR--YLITSYSGVLAADVDQ-TTFSANEKK 69 Query: 102 AMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIE-ELRKS 160 +++ G+ ++ + +V RR +++ + K+ +++ E A ++ + Sbjct: 70 SLM-LRAMGHSMLRKDDPDHQVERRAWQPSLKPGTV-KKVWKQKFAENADRYLDAYIDAG 127 Query: 161 KGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELF 220 G+ F + N+ I F Q + Q Sbjct: 128 SGSDFMQGFAAPFVAENLRALIGFENASEADLQR------------------WSQTLIDG 169 Query: 221 SGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAH 280 +G P + ++ EI+A + ++ H P D + +YLL A Sbjct: 170 AGNYPDDPDVWAKAKQSSDEIDAALEEMIQWH-----SGRPGDSLLSYLLRS------AD 218 Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 + +++ N G L L +L E V R+ Sbjct: 219 YQMPLESIRSNIKMTIGGGLNEPRDVLGVSTLALLSSSKQLELVLRD------------- 265 Query: 341 HDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPH 400 AV E R+ + M VP T GY IP+ ++ L + +A D Sbjct: 266 -----PKLWGAVFEESIRWVAPIGM-VPRQTVVDTELDGYFIPRGAKLGLCILSANRDRS 319 Query: 401 YFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELF-LFFTTILQNFSM 459 + PD F+ + +EA + F G +CLG AR+++ + + Sbjct: 320 VWSDPDRFDIER---------GSEAHLAFGKGVHVCLGAWAARSQVADVGLPALFSRLKG 370 Query: 460 ASPVAPEDIDLTPQEC-GVGKIPPTYQ 485 ++ G +P + Sbjct: 371 LRLDPNQEATHGGWVFRGPLSLPLVWD 397 >3OFT-A nrPDB Length = 396 Score = 120 bits (300), Expect = 2e-27, Method: Composition-based stats. Identities = 59/366 (16%), Positives = 108/366 (29%), Gaps = 64/366 (17%) Query: 123 VLRRFSVTTMRDFGM-GKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICS 181 + F M+ ++E ++Q A+ L+E LR D F I Sbjct: 93 EHKAFRTPVMKGLASRFVVALEPKVQAVARKLMESLR--PRGSCDFVSDFAEIL------ 144 Query: 182 IVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEI 241 LN+F + +L +L + P V + Q Sbjct: 145 ----------------PLNIFLTLIDVPLEDRPRLRQLGVQLTR--PDGSMTVEQLKQAA 186 Query: 242 NAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTE 301 + Y+ +EK + P D + + +L + ++ +L F G + Sbjct: 187 DDYLWPFIEKR-----MAQPGDDLFSRIL----SEPVGGRPWTVDEARRMCRNLLFGGLD 237 Query: 302 TTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSD 361 T + + L + ++P + + A E+ R Sbjct: 238 TVAAMIGMVALHLARHPEDQRLLRERPD------------------LIPAAADELMRRYP 279 Query: 362 LLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALK 421 + V G I K V+L DP FE P+ D L Sbjct: 280 TV--AVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLA------ 331 Query: 422 KTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGV-GKI 480 +G C+G G+AR E+ +F L + + + + G + Sbjct: 332 -PIRHTTMGVGAHRCVGAGLARMEVIVFLREWLGGMPEFALAPDKAVTMKGGNVGACTAL 390 Query: 481 PPTYQI 486 P ++ Sbjct: 391 PLVWRA 396 >3WEC-A nrPDB Length = 419 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 59/399 (14%), Positives = 114/399 (28%), Gaps = 66/399 (16%) Query: 78 LCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYG--VIFANGNRWKVLRRFSVTTMRDF 135 L G + D + G + G + + LR Sbjct: 63 LFGKDFANSTFFDHLTSMMGEDMPPFLGLGIDGDARPFMLTDPPEHTRLRGLVSDAFT-- 120 Query: 136 GMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEF 195 S+++ + A + L A+ + + + ++ SI+ +D+ Sbjct: 121 RSTTTSMDDIVLSAASSAVRHLEHCTDAV---SEVAEPFPVEVLSSIL---GIPDKDRGR 174 Query: 196 LKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRET 255 + I+ + + ++E Y Sbjct: 175 FSEWSNLVAGVLDINFAIPKEV-------------ADRRSAAIEESIDYFRTLAT----- 216 Query: 256 LDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315 +AP+ L+ E S+ + S + L + AG ETTS T+ + Sbjct: 217 -SGNAPE-----GLVRRLSEVSHGGDQLSVDEIAATCLLITVAGQETTSNTIGNMLITFS 270 Query: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375 ++ E+V RA + E + E+ RF I + Sbjct: 271 RHADQFEQV------------------RANPQFIENAVAEVLRFEPPAHEA-GRIALEDC 311 Query: 376 SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRI 435 G I K V ++L++ E+ D F + + + + G Sbjct: 312 EVSGANITKGDAVMVLLASGNR--EAVERGDTF---------SVTRPDVSSLSYGRGIHH 360 Query: 436 CLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQE 474 CLG +A + L F + Q + P I+ P Sbjct: 361 CLGSALANSMLQHFLRELSQRYRSIEVAEP--INYKPGM 397 >6BLD-A nrPDB Length = 419 Score = 118 bits (296), Expect = 4e-27, Method: Composition-based stats. Identities = 53/349 (15%), Positives = 110/349 (31%), Gaps = 53/349 (15%) Query: 117 NGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITA 176 + R LR+ + R +E+ I+ A+ +++ELR + G + + + Sbjct: 106 DPPRHTKLRKLVSAAFTPRQV--RRIEDSIKINAKGIVDELRMAGGGVDFVEHCAKELPI 163 Query: 177 NIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYK 236 + +V D+E + +L+S + F Sbjct: 164 RTLSDMV---GIPEADRERVAHAAD-----ALVSWADPRYLNGREPLAVLFEN------- 208 Query: 237 NLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLF 296 Q + S+ R P D + + L++ E + + ++ + L Sbjct: 209 --QMYLHQVAASLAAERR----DRPGDDLFSALVNAEVDGD----RLADADVAAFFVLLA 258 Query: 297 FAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEI 356 AG +TT T+ +G + +P + + + IG + E+ Sbjct: 259 VAGNDTTRQTISHGLKALTDFPSQKAWLLADFDTRIG-----------------TAVEEL 301 Query: 357 QRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDA 416 R++ + M G +I +V + ++ D F P+ + + Sbjct: 302 VRWATPV-MTFRRTAAADFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNP 360 Query: 417 NGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAP 465 + CLG +ARA+L F +L P Sbjct: 361 HVGFGGGGVH--------FCLGAHLARAQLRAIFGELLVQLPDIQAGDP 401 >5YHJ-A nrPDB Length = 413 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 74/437 (16%), Positives = 146/437 (33%), Gaps = 60/437 (13%) Query: 40 LGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRG 99 L + + R G L R + ++F L V+ L G EA Sbjct: 11 LDHSVDFLREGYLFVANRRKSFQSNIFESRLLGERVICLGGEEAAEVFYDANKFTRQDAA 70 Query: 100 KIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRK 159 ++ F GV +G+ ++ ++ M K +++ ++ + + R Sbjct: 71 PKRLLKTLFGEGGVQTLDGSEHTHRKQMFMSLM-----TKENIDRLLRLTYREWNQIERM 125 Query: 160 SKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFEL 219 G + + Q + +C + + + + L +++ + + Sbjct: 126 --GEEIVLYDIAQEVLMKAVCEWSGVPLAKEEVGKRTEEMRLLFESGTSLGP-------- 175 Query: 220 FSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRE-TLDPSAPKDLIDTYLLHMEKEKSN 278 + Q K +I V++ R L P+ T L + Sbjct: 176 ----------TYLQGRKARSSAEVWIRQMVKEVRSNRLLPNEH-----TALYEFSWHRDE 220 Query: 279 AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP 338 + + + + L++ + L + L + ++P V E+V Sbjct: 221 SGELLPEEVVAVEVLNILRPTVAISVYVL-FTVLALHQFPDVKEQV-------------- 265 Query: 339 ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHD 398 +R ++ TE + E++RF P+ + T + GY P+ T L L HD Sbjct: 266 ---ERGEVSKTE-FVQEVRRFYPFFPVAAARVKT-DFEWDGYAFPEGTLTLLDLYGTNHD 320 Query: 399 PHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGK----RICLGEGIARAELFLFFTTIL 454 + +PD F+P F D + FIP G C GE + A L Sbjct: 321 VSIWTEPDRFDPSRFKDWK---ESPFNFIPQGGGDVDFGHRCAGEHVTIAILAQVIELFT 377 Query: 455 QNFSMASPVAPEDIDLT 471 + + A V P+D+ + Sbjct: 378 KEY--AYTVPPQDLSYS 392 >5D3U-A nrPDB Length = 427 Score = 115 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 48/260 (18%), Positives = 86/260 (33%), Gaps = 40/260 (15%) Query: 205 TFSLISSVFGQLFELFSGFLKYFPGAHRQ------VYKNLQEINAYIGHSVEKHRETLDP 258 F + G L + + YF G Q + + L +++ Y ++ R + P Sbjct: 175 AFGVPEEDLGFLIPRVNTIMTYFSGPKDQPVTQEIILEKLTDLHTYASELLQGMRGKVLP 234 Query: 259 SAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP 318 D + L + + E + L L ++LF TT +L G L + P Sbjct: 235 ----DTVIARLAAAQDGLTETTPEQTVHQLALVFIALFAP---TTPGSLSSGTLAFARNP 287 Query: 319 HVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378 ER + V + E+ R++ + + Sbjct: 288 RQVERFLADQACV------------------DNTANEVLRYNASNQF-TWRVAAKDVEMG 328 Query: 379 GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLG 438 G I + L L +A D + FE+P+ F+ D + + F G CL Sbjct: 329 GVRIEAGQTLALFLGSANRDANMFERPNDFDLDR--------PNSARHLSFGQGVHACLA 380 Query: 439 EGIARAELFLFFTTILQNFS 458 + +L F+ +L F Sbjct: 381 AQLISLQLKWFYVALLNRFP 400 >3B98-A nrPDB Length = 475 Score = 115 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 90/511 (17%), Positives = 166/511 (32%), Gaps = 82/511 (16%) Query: 20 VQRHPNT--------HDRLPPGPRP-LPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHL 70 + + ++ PP + +P LG+ L+ + K R +EK+GD+FTV Sbjct: 1 MAKKTSSVLYGRRTRRRNEPPLDKGMIPWLGHALEFGKDA-AKFLTRMKEKHGDIFTVRA 59 Query: 71 GPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVT 130 + +L L D A ++ F ++ ++ + R Sbjct: 60 AGLYITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFNM--ILPSHNPESEKKRAEMHF 117 Query: 131 TMRDFGMGKRSVEERIQ-----EEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFG 185 S++ ++ E E +K L S+ VFG Sbjct: 118 QGASLTQLSNSMQNNLRLLMTPSEMGLKTSEWKKDG-----LFNLCYSLLFKTGYLTVFG 172 Query: 186 KRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQ-VYKNLQEINAY 244 + S+ Q++E F F K P R V K ++I + Sbjct: 173 AENNN-------------------SAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASA 213 Query: 245 IGHSVEKHRE-TLDPSAPKDL--IDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFF---- 297 + K + P++ + +Y+ ++ E +A + L L+ Sbjct: 214 AREKLWKWLTPSGLDRKPREQSWLGSYVKQLQDEGIDAEMQ-----RRAMLLQLWVTQGN 268 Query: 298 AGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKM-PYTEAVIYEI 356 AG + +L +P V EI+ + L +R K P ++V++E Sbjct: 269 AG-----PAAFWVMGYLLTHPEALRAVREEIQ----GGKHLRLEERQKNTPVFDSVLWET 319 Query: 357 QRFSDLLPMGVPHIVTQHTSFR-----GYIIPKDTEVFLILS-TALHDPHYFEKPDAFNP 410 R + + VTQ Y + + + + + DP ++P+ F Sbjct: 320 LRLTAAA--LITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQF 377 Query: 411 DHFLDANGALKK---------TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 461 D FL+A+ KK +P+ +C G A + TIL F + Sbjct: 378 DRFLNADRTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVEL 437 Query: 462 PVAPEDIDL-TPQECGVGKIPPTYQIRFLPR 491 + L P G G + P + R Sbjct: 438 CDKNATVPLVDPSRYGFGILQPAGDLEIRYR 468 >4FB2-A nrPDB Length = 398 Score = 112 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 73/463 (15%), Positives = 133/463 (28%), Gaps = 79/463 (17%) Query: 23 HPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVE 82 H P GP P + R + + + E YG VV G + Sbjct: 6 TTADHYHTPLGPDGTPHA--FFEALRDEAETTPIGWSEAYG--------GHWVVA--GYK 53 Query: 83 AIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSV 142 I +A++ +AFS +G + G + G V +++ + F Sbjct: 54 EI-QAVIQNTKAFSNKGV--TFPRYETGEFELMMAGQDDPVHKKYRQLVAKPFS------ 104 Query: 143 EERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLF 202 E E+LR+S L+D G + E L Sbjct: 105 ----PEATDLFTEQLRQSTNDLIDARIELGE-----------GDAATWLANEIPARLTAI 149 Query: 203 YQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPK 262 G + + + + + + E+ A+ + + R + Sbjct: 150 LLGLPPED---GDTYRRWVWAITHVENP-EEGAEIFAELVAHARTLIAERR----TNPGN 201 Query: 263 DLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAE 322 D++ ++ +S S +L L G + T+ L F + + Sbjct: 202 DIMSRVIMSKIDGES-----LSEDDLIGFFTILLLGGIDNTARFLSSVFWRLAWDIELRR 256 Query: 323 RVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYII 382 R+ A + E+ RF +G +VTQ + + Sbjct: 257 RL------------------IAHPELIPNAVDELLRFYGPAMVG--RLVTQEVTVGDITM 296 Query: 383 PKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIA 442 L A D F+ PD + + G CLG + Sbjct: 297 KPGQTAMLWFPIASRDRSAFDSPDNIVIER---------TPNRHLSLGHGIHRCLGAHLI 347 Query: 443 RAELFLFFTTILQNFSMASPVAPEDID-LTPQECGVGKIPPTY 484 R E + T L+ S ++ + L Q G+ +P + Sbjct: 348 RVEARVAITEFLKRIPEFSLDPNKECEWLMGQVAGMLHVPIIF 390 >2WIY-A nrPDB Length = 394 Score = 112 bits (280), Expect = 4e-25, Method: Composition-based stats. Identities = 52/366 (14%), Positives = 94/366 (25%), Gaps = 57/366 (15%) Query: 116 ANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSIT 175 ++ VLRR + +E L++ G +++ + Sbjct: 82 SDPPHHTVLRRQTNKWFTP--KLVDGWVRTTRELVGDLLD--GVEAGQVIEARRDLAVVP 137 Query: 176 ANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVY 235 ++ + V D M F L Sbjct: 138 THVTMARVLQLPEDDADAVMEAM---------------------FEAMLMQSAEPADGDV 176 Query: 236 KNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSL 295 Y+ V + E + L D+ L E + L Sbjct: 177 DRAAVAFGYLSARVAEMLEDKRVNPGDGLADSLLDAARA------GEITESEAIATILVF 230 Query: 296 FFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYE 355 + G + G L + P V + A+I E Sbjct: 231 YAVGHMAIGYLIASGIELFARRPEVFTAFRNDESARA------------------AIINE 272 Query: 356 IQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLD 415 + R + T+ G +I + + ++ A DP F+ PD F+ Sbjct: 273 MVRMDPP-QLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR--- 328 Query: 416 ANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQEC 475 A + + F LG C G+ I+RAE F + + + + Sbjct: 329 PPAASRN----LSFGLGPHSCAGQIISRAEATTVFAVLAERYERIELAEEPTVAHNDFAR 384 Query: 476 GVGKIP 481 K+P Sbjct: 385 RYRKLP 390 >2IJ7-A nrPDB Length = 396 Score = 111 bits (277), Expect = 8e-25, Method: Composition-based stats. Identities = 51/341 (14%), Positives = 101/341 (29%), Gaps = 58/341 (17%) Query: 127 FSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGK 186 M+ +E+ +++ A L++ L ++GA D F A + V G Sbjct: 94 LRKAVMKAITPKAPGLEQFLRDTANSLLDNL-ITEGAPADLRNDFADPLATALHCKVLGI 152 Query: 187 RFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIG 246 + F + F + I + + I + Sbjct: 153 PQEDGPKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPN---------ITTGLM 203 Query: 247 HSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTT 306 + + R K A+S S + ++ F AG +T + Sbjct: 204 GELSRLR----------------------KDPAYSHVSDELFATIGVTFFGAGVISTGSF 241 Query: 307 LRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMG 366 L + +++ P + ++ K A + E+ R + G Sbjct: 242 LTTALISLIQRPQLRNLLHE------------------KPELIPAGVEELLRINLSFADG 283 Query: 367 VPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAF 426 +P + T ++ K V ++L A DP +F P + D + Sbjct: 284 LPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDR--------PNPTSH 335 Query: 427 IPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPED 467 + F G+ C G + R + +L+ P D Sbjct: 336 LAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPID 376 >2IAG-A nrPDB Length = 482 Score = 110 bits (276), Expect = 9e-25, Method: Composition-based stats. Identities = 88/501 (17%), Positives = 172/501 (34%), Gaps = 73/501 (14%) Query: 32 PGPRPL-----PLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIRE 86 PG PL P LG L + R +EK+GD+FT+ +G R V +L + + Sbjct: 5 PGEPPLDLGSIPWLGYALDFGKDA-ASFLTRMKEKHGDIFTILVGGRYVTVLLDPHS-YD 62 Query: 87 ALVDKAE---AFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVE 143 A+V + F +++ F ++ + ++ T+ + + Sbjct: 63 AVVWEPRTRLDFHAYAIF-LMERIFDVQLPHYSPSDEKARMK----LTLLHRELQALTEA 117 Query: 144 ERIQEEAQCLIEELRKSKG----ALMDPTFLF----QSITANIICSIVFGKRFHYQDQEF 195 A L + G L+D ++ F +T I ++ + Q Q+ Sbjct: 118 MYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEAL--PRTHESQAQDR 175 Query: 196 LKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRET 255 + ++F+ F QL L + + ++ + + + + R Sbjct: 176 VHSADVFH--------TFRQLDRLLPKLARGSLSVGDK--DHMCSVKSRLWKLLSPARLA 225 Query: 256 LDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315 K +++YLLH+E+ S + + +A + L +L Sbjct: 226 RRAHRSK-WLESYLLHLEEMG------VSEEMQARALVLQLWATQGNMGPAAFWLLLFLL 278 Query: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKM-------PYTEAVIYEIQRFSDLLPMGVP 368 K P V E+E ++ P P ++V+ E R + + Sbjct: 279 KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAP--FIT 336 Query: 369 HIVTQHTSF-----RGYIIPKDTEVFLIL-STALHDPHYFEKPDAFNPDHFLDANGALKK 422 V + R + + + + L + DP + P+ F + FL+ +G+ KK Sbjct: 337 REVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKK 396 Query: 423 ---------TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP---VAPEDIDL 470 +P+ G CLG A + F +L + + V + DL Sbjct: 397 DFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDL 456 Query: 471 TPQECGV----GKIPPTYQIR 487 + G+ +P Y+IR Sbjct: 457 SRYGFGLMQPEHDVPVRYRIR 477 >2QBO-A nrPDB Length = 421 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 56/370 (15%), Positives = 107/370 (28%), Gaps = 67/370 (18%) Query: 117 NGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITA 176 + + R + + + K +E RIQE A LIE LR + T + Sbjct: 105 DPPEQRQFRALANQVVGMPVVDK--LENRIQELACSLIESLR--PQGQCNFTEDYAE--- 157 Query: 177 NIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYK 236 + + F+ + L + + + Q+ P + Sbjct: 158 ------------PFPIRIFMLLAGLPEEDIPHLKYLTDQMTR---------PDGSMTFAE 196 Query: 237 NLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLF 296 + + Y+ +E+ R+ A + + + L Sbjct: 197 AKEALYDYLIPIIEQRRQKPGTDA---------ISIVANGQVNGRPITSDEAKRMCGLLL 247 Query: 297 FAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEI 356 G +T L + + K P + + E++ A E+ Sbjct: 248 VVGLDTVVNFLSFSMEFLAKSPEHRQELIERPERI------------------PAACEEL 289 Query: 357 QRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDA 416 R L+ G I+T F G + K ++ L + D P + Sbjct: 290 LRRFSLVADG--RILTSDYEFHGVQLKKGDQILLPQMLSGLDERENACPMHVDFSR---- 343 Query: 417 NGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDL-TPQEC 475 + + F G +CLG+ +AR E+ + L S I + Sbjct: 344 -----QKVSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQIQHKSGIVS 398 Query: 476 GVGKIPPTYQ 485 GV +P + Sbjct: 399 GVQALPLVWD 408 >2ZQJ-A nrPDB Length = 417 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 71/428 (16%), Positives = 128/428 (29%), Gaps = 54/428 (12%) Query: 40 LGNLLQMDRRGLLKSFLRFREKY-GDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGR 98 L N L + + G L E+Y D+F L + + + G EA + D Sbjct: 11 LDNSLTLLKEGYL-FIKNRTERYNSDLFQARLLGKNFICMTGAEAAK-VFYDTDRFQRQN 68 Query: 99 GKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELR 158 V G I + R+ ++ KR + E + EE + + Sbjct: 69 ALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSLMTPPHQKR-LAELMTEEWKAAVTRWE 127 Query: 159 KSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFE 218 K+ + + I + C + ++ E + + F +V Sbjct: 128 KADEVV--LFEEAKEILCRVAC---YWAGVPLKETEVKERADDFIDMVDAFGAVGP---- 178 Query: 219 LFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSN 278 H + + +I +E R L + + H +++ S Sbjct: 179 -----------RHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMAFHTQEDGSQ 227 Query: 279 AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP 338 S + L + S L + L + ++P E + Sbjct: 228 LDSRMAAIELINVLRPIVA-----ISYFLVFSALALHEHPKYKEWLRS------------ 270 Query: 339 ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHD 398 E + E++R+ P + +V + + K T V L L HD Sbjct: 271 -----GNSREREMFVQEVRRYYPFGPF-LGALVKKDFVWNNCEFKKGTSVLLDLYGTNHD 324 Query: 399 PHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGK----RICLGEGIARAELFLFFTTIL 454 P ++ PD F P+ F + L IP G C GEGI + ++ Sbjct: 325 PRLWDHPDEFRPERFAEREENL---FDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLV 381 Query: 455 QNFSMASP 462 P Sbjct: 382 HQIEYDVP 389 >5OMS-A nrPDB Length = 409 Score = 107 bits (268), Expect = 1e-23, Method: Composition-based stats. Identities = 47/354 (13%), Positives = 98/354 (27%), Gaps = 47/354 (13%) Query: 102 AMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSK 161 F +I NG+ LR ++ + R +++ ++ A+ +E Sbjct: 71 PAGGRTFGHPAIIGVNGDIHADLRSMVEPALQPAEV-DRWIDDLVRPIARRYLERFEN-- 127 Query: 162 GALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFS 221 D + + G Q+ + K+ F + ++ F+ Sbjct: 128 ----DGHAELVAQYCEPVSVRSLGDLLGLQEVDSDKLREWFAKLNRSFTNAAVDENGEFA 183 Query: 222 GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHS 281 P + + EI A + ++K E D D+ + H + Sbjct: 184 N-----PEGFAEGDQAKAEIRAVVDPLIDKWIEHPD--------DSAISHWLHDGMPPGQ 230 Query: 282 EFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELH 341 + + + + + + P E V + Sbjct: 231 TRDREYIYPTIYVYLLGAMQEPGHGMASTLVGLFSRPEQLEEVVDD-------------- 276 Query: 342 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 401 I E R++ + I T+ + G +P T V L +A HD Sbjct: 277 ----PTLIPRAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLSYGSANHDTGK 332 Query: 402 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQ 455 +E P ++ + F G C G A + + + + Sbjct: 333 YEAPSQYDLHR---------PPLPHLAFGAGNHACAGIYFANHVMRIALEELFE 377 >5M0P-A nrPDB Length = 428 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 67/436 (15%), Positives = 139/436 (31%), Gaps = 51/436 (11%) Query: 40 LGNLLQMDRRGLLKSFLRFREKYGDVFTVH-LGPRPVVMLCGVEAIREALVDKAEAFSGR 98 L N L++ ++G L + + VF LG +P V++ G E + G Sbjct: 16 LDNTLKVLKQGYLYTTNQRNRLNTSVFQTKALGGKPFVVVTGKEGAEMFYNNDVVQREGM 75 Query: 99 GKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELR 158 +V+ + +G + + ++ M + + + L L Sbjct: 76 LPKRIVNTLAGKGAIHTVDGKKHVDRKALFMSLMTEGNLN----------YVRELTRTLW 125 Query: 159 KSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFE 218 + M+ +I+ G R+ + + I++ + + Sbjct: 126 HANTQRMESMDEVNIYRESIVLLTKVGTRW--------AGVQAPPEDIERIATDMDIMID 177 Query: 219 LFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSN 278 F F G ++ + + + ++ + + R+ + P+ H E N Sbjct: 178 SFRALGGAFKG-YKASKEARRRVEDWLEEQIIETRK-GNIHPPEGTALYEFAHWEDYLGN 235 Query: 279 AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP 338 + +NT A + + +G M + P E++ E + Sbjct: 236 PMDSRTCAIDLMNTFRPLIA----INRFVSFGLHAMNENPITREKIKSEPD--------- 282 Query: 339 ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHD 398 Y E++R+ +P +P F+G IP + L + HD Sbjct: 283 ---------YAYKFAQEVRRYYPFVPF-LPGKAKVDIDFQGVTIPAGVGLALDVYGTTHD 332 Query: 399 PHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLG----KRICLGEGIARAELFLFFTTIL 454 ++ P+ F P+ F +G+ IP G C GE I + Sbjct: 333 ESLWDDPNEFRPERFETWDGS---PFDLIPQGGGDYWTNHRCAGEWITVIIMEETMKYFA 389 Query: 455 QNFSMASPVAPEDIDL 470 + + P ++DL Sbjct: 390 EKITYDVPEQDLEVDL 405 >5KYO-A nrPDB Length = 430 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 58/414 (14%), Positives = 107/414 (25%), Gaps = 71/414 (17%) Query: 65 VFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVI--FANGNRWK 122 ++T H G V + + E ++ E FS + + Y +I + + Sbjct: 75 MWTPHNGGHWVALRSD---LAETVMSDFERFSNHTVLVPKETAGEAYRLIPLSLDPPEHR 131 Query: 123 VLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSI 182 R + + R +E+ + + A LIE R Sbjct: 132 PFRSLLNENLGPKPL--RPIEQVVTDLAVSLIEGFRPK-------------------GRC 170 Query: 183 VFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEIN 242 F F Q + +F + L +L L + + P + ++ Sbjct: 171 NFTHEFAEQLP-----VRIFMRIVDLPVEDLPKLKHLADQYTR--PDGSIPLDDVTKQFR 223 Query: 243 AYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTET 302 Y+ +E R +D+I + + + + G +T Sbjct: 224 EYLRPVIEARR----IKPGEDMISRMI-----NGEVGGRPLTDIEAENICIQVLVGGLDT 274 Query: 303 TSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDL 362 L + F + K H R A + + E R + Sbjct: 275 VVNMLGFTFSHLAKD-HALRRAIA-----------------ADPSLIDDALLEFFRRFPV 316 Query: 363 LPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK 422 + V + F G ++ V D E P F K Sbjct: 317 V--SSAREVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGR---------K 365 Query: 423 TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECG 476 F G C G +AR E+ + + + G Sbjct: 366 ARQHSTFGKGSHTCPGAHLARMEMKVVLREWFARIPEFRIEDDAPLRYSNGIVG 419 >3BUJ-A nrPDB Length = 397 Score = 105 bits (261), Expect = 6e-23, Method: Composition-based stats. Identities = 40/256 (15%), Positives = 86/256 (33%), Gaps = 40/256 (15%) Query: 232 RQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLN 291 R+ + + E Y+ ++ +DL+ L ++ S + Sbjct: 177 RRGHAAIAEFADYVERAL----ARRRREGGEDLLALMLDAHDR------GLMSRNEIVST 226 Query: 292 TLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEA 351 ++ F G ET ++ + L +L +P + + R + Sbjct: 227 VVTFIFTGHETVASQVGNAVLSLLAHPDQLDLLRRRPD------------------LLAQ 268 Query: 352 VIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPD 411 + E R+ + + RG + +D V ++ A DP +++PD F+ + Sbjct: 269 AVEECLRYDPSVQSNT-RQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIE 327 Query: 412 HFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLT 471 + F G R CLG +AR +L + + + A + + Sbjct: 328 R---------DPVPSMSFGAGMRYCLGSYLARTQLRAAVAALARLPGLRLGCASDALAYQ 378 Query: 472 PQEC--GVGKIPPTYQ 485 P+ G+ +P + Sbjct: 379 PRTMFRGLASLPIAFT 394 >3AWQ-A nrPDB Length = 415 Score = 99.4 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 67/432 (15%), Positives = 126/432 (29%), Gaps = 55/432 (12%) Query: 44 LQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAM 103 L + + + + F + L G +A G +A+ Sbjct: 14 LSLLADPYRFISRQCQRLGANAFESRFLLKKTNCLKGAKAAEIFYDTTRFEREGAMPVAI 73 Query: 104 VDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGA 163 F GV +G + ++ + M + R++ + + E + + + KG Sbjct: 74 QKTLFGQGGVQGLDGETHRHRKQMFMGLMTPERV--RALAQLFEAEWRRAVPGWTR-KGE 130 Query: 164 LMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGF 223 ++ L + +T ++ D E F S Sbjct: 131 IVFYDELHEPLTR----AVCAWAGVPLPDDEAGNRAGELRALFDAAGSASP--------- 177 Query: 224 LKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEF 283 H + ++A+ +E R S + + H + Sbjct: 178 ------RHLWSRLARRRVDAWAKRIIEGIRAGSIGS-----GSGTAAYAIAWHRDRHDDL 226 Query: 284 SHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYRE-IEQVIGPHRPPELHD 342 ++ A E L+ + P VA VY + + Sbjct: 227 LSPHV---------AAVE----------LVNVLRPTVAIAVYITFVAHALQTCSGIRAAL 267 Query: 343 RAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYF 402 + Y E + E++RF P V +Q + G P+ +V L L + HD + Sbjct: 268 VQQPDYAELFVQEVRRFYPFFPAVVAR-ASQDFEWEGMAFPEGRQVVLDLYGSNHDAATW 326 Query: 403 EKPDAFNPDHFLDANGALKKTEAFIPFSLGK----RICLGEGIARAELFLFFTTILQNFS 458 P F P+ F + + + FIP G C GE I A + + ++ Sbjct: 327 ADPQEFRPERFRAWD---EDSFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMR 383 Query: 459 MASPVAPEDIDL 470 P ID Sbjct: 384 YDVPDQDLSIDF 395 >3NV6-A nrPDB Length = 452 Score = 92.5 bits (228), Expect = 4e-19, Method: Composition-based stats. Identities = 52/425 (12%), Positives = 124/425 (29%), Gaps = 67/425 (15%) Query: 65 VFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFA--NGNRWK 122 ++T G + + ++E D S I + Y ++ + Sbjct: 90 IWTPFTGGHWIA--TNGDTVKEVYSDPTRFSS--EVIFLPKEAGEKYQMVPTKMDPPEHT 145 Query: 123 VLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSI 182 R+ + + K VE++++E A LI+ D + + Sbjct: 146 PYRKALDKGLNLAKIRK--VEDKVREVASSLIDSFAAR--GECDFAAEYAEL-------- 193 Query: 183 VFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEIN 242 + F+ + +L + ++S Q+ G + N Sbjct: 194 -------FPVHVFMALADLPLEDIPVLSEYARQMTRP-EGNTPEEMATDLEAGNN--GFY 243 Query: 243 AYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTET 302 AY+ + D + T +++ E +H L G +T Sbjct: 244 AYVDPIIRAR-----VGGDGDDLITLMVNSE----INGERIAHDKAQGLISLLLLGGLDT 294 Query: 303 TSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDL 362 L + + + ++P + + + +++ E+ R + Sbjct: 295 VVNFLSFFMIHLARHPELVAELRSDPLKLMRGA------------------EEMFRRFPV 336 Query: 363 LPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK 422 + +V + ++G + + + L + D +P + + Sbjct: 337 V--SEARMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSR---------R 385 Query: 423 TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPEDIDLTPQECGVGKIP 481 + + F G C G +AR E+ + L+ + I + V +P Sbjct: 386 SISHSTFGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPIYHSGIVAAVENVP 445 Query: 482 PTYQI 486 + I Sbjct: 446 LVWPI 450 >4C9K-A nrPDB Length = 421 Score = 84.0 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 43/307 (14%), Positives = 83/307 (27%), Gaps = 44/307 (14%) Query: 182 IVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEI 241 FG F + + +F L +L L + + + ++L+ Sbjct: 150 CEFGSEFS-----TVFPVRVFLALAGLPVEDATKLGLLANEMTRPSGNTPEEQGRSLEAA 204 Query: 242 NAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTE 301 N V + DLI L L G + Sbjct: 205 NKGFFEYVAPIIAARRGGSGTDLITRIL-----NVEIDGKPMPDDRALGLVSLLLLGGLD 259 Query: 302 TTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSD 361 T L + + + ++P + RE + + + E+ R Sbjct: 260 TVVNFLGFMMIYLSRHPETVAEMRREPLK------------------LQRGVEELFRRFA 301 Query: 362 LLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALK 421 ++ V F G ++ + + L + D + + P + Sbjct: 302 VV--SDARYVVSDMEFHGTMLKEGDLILLPTALHGLDDRHHDDPMTVDLSRRD------- 352 Query: 422 KTEAFIPFSLGKRICLGEGIARAELFLFFTTILQN---FSMASPVAPEDIDLTPQECGVG 478 F+ G C G +AR E+ + L F + P I + V Sbjct: 353 --VTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLKDRAVP--IYHSGIVAAVE 408 Query: 479 KIPPTYQ 485 IP ++ Sbjct: 409 NIPLEWE 415 >2RCM-A nrPDB Length = 495 Score = 81.7 bits (200), Expect = 7e-16, Method: Composition-based stats. Identities = 78/494 (15%), Positives = 138/494 (27%), Gaps = 83/494 (16%) Query: 20 VQRHPNTHDRLP------------------PGPRPLPLLGNLLQ----MDRRGLLKSFLR 57 + + ++ P PG LP++G + +G + F Sbjct: 1 MAKKTSSGSETPDLTVATRTGSKDLPIRNIPGNYGLPIVGPIKDRWDYFYDQGAEEFFKS 60 Query: 58 FREKY-GDVFTVHLGP--------RPVVMLCGVEAIREALVDKAEAFSG-RGKIAMVDPF 107 KY V+ V++ P + V +L G VDK E G Sbjct: 61 RIRKYNSTVYRVNMPPGAFIAENPQVVALLDGKSFPVLFDVDKVEKKDLLTGTYMPSTEL 120 Query: 108 FRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKS---KGAL 164 GY ++ + + + Q L + L K KG Sbjct: 121 TGGYRILSYLDPSEPKHEKLKNLLFFLLKSSRNRIFPEFQATYSELFDSLEKELSLKGKA 180 Query: 165 MDPTFLFQSITANIICSIVFGK-----RFHYQDQEFLKMLNLFYQTFSLISSVFGQLFEL 219 D N + +G + + LF L+S ++ E Sbjct: 181 -DFGGSSDGTAFNFLARAFYGTNPADTKLKADAPGLITKWVLFN-LHPLLSIGLPRVIE- 237 Query: 220 FSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDP-SAPKDLIDTYLLHMEKEKSN 278 + F V + Q + + S + D ++ LL + Sbjct: 238 -EPLIHTFSLPPALVKSDYQRLYEFFLESAGEILVEADKLGISREEATHNLLFATCFNTW 296 Query: 279 AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHR-P 337 + N+ AG V R+ EI VI + Sbjct: 297 GGMKILFPNMVKRIGR---AGH------------------QVHNRLAEEIRSVIKSNGGE 335 Query: 338 PELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGY----IIPKDTEVFLILS 393 + KM T++V+YE RF + + + + ++ Sbjct: 336 LTMGAIEKMELTKSVVYECLRFEPPVTAQYGR-AKKDLVIESHDAAFKVKAGEMLYGYQP 394 Query: 394 TALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGK---------RICLGEGIARA 444 A DP F++ D F P+ F+ G +K + +S G + C G+ Sbjct: 395 LATRDPKIFDRADEFVPERFVGEEG--EKLLRHVLWSNGPETETPTVGNKQCAGKDFVVL 452 Query: 445 ELFLFFTTILQNFS 458 LF I + + Sbjct: 453 VARLFVIEIFRRYD 466 >3DBM-A nrPDB Length = 473 Score = 72.8 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 71/461 (15%), Positives = 138/461 (29%), Gaps = 58/461 (12%) Query: 32 PGPRPLPLLGNL-----LQMDRRGLLKSFLRFREKY-GDVFTVHLGPRP-------VVML 78 PG +P + G + F +KY VF ++ P P V++L Sbjct: 12 PGSYGIPFFQPIKDRLEYFYGTGGRDEYFRSRMQKYQSTVFRANMPPGPFVSSNPKVIVL 71 Query: 79 CGVEAIREAL----VDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRD 134 ++ V+K + F+G GY V+ + Sbjct: 72 LDAKSFPILFDVSKVEKKDLFTG--TYMPSTKLTGGYRVLSYLDPSEPRHAQLKNLLFFM 129 Query: 135 FGMGKRSVEERIQEEAQCLIEELRKS--KGALMDPTFLFQSITANIICSIVFGKRFHYQD 192 V + + L E L K + + + F + ++ Sbjct: 130 LKNSSNRVIPQFETTYTELFEGLEAELAKNGKAAFNDVGEQAAFRFLGRAYFNS--NPEE 187 Query: 193 QEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKH 252 + ++ L + +L + P H I + + Sbjct: 188 TKLGTSAPTLISSWVLFN--LAPTLDLGLPWFLQEPLLHTFRLPAF-LIKSTYNKLYDYF 244 Query: 253 RETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETT-STTLRY-G 310 + P + + EK + + N+ F G + TL++ G Sbjct: 245 QSVATP-----------VMEQAEKLGVPKDEAVHNILFAVCFNTFGGVKILFPNTLKWIG 293 Query: 311 FLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHI 370 + +AE + I+ L +MP T++V+YE R +P Sbjct: 294 LAGENLHTQLAEEIRGAIKSY--GDGNVTLEAIEQMPLTKSVVYESLRIEPPVPPQYG-K 350 Query: 371 VTQHTSFRGY----IIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAF 426 + + + + K +F A DP F++P+ + PD F+ AL K + Sbjct: 351 AKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDGEALLK---Y 407 Query: 427 IPFSLGK---------RICLGEGIARAELFLFFTTILQNFS 458 + +S G + C G+ LF + + + Sbjct: 408 VWWSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYD 448 >2YJN-B nrPDB Length = 381 Score = 60.1 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 30/135 (22%), Positives = 50/135 (37%), Gaps = 20/135 (14%) Query: 292 TLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEA 351 L FAG E T+ T+ L + P +AER+ + + Sbjct: 216 ALRALFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAA------------------AQR 257 Query: 352 VIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPD 411 + E+ R L + T ++I + EV ++++ A DP F +PD + D Sbjct: 258 TVAEVLRLHPALHLE-RRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVD 316 Query: 412 HFLDANGALKKTEAF 426 DA+ AL Sbjct: 317 R-PDADRALSAHRGH 330 >5V0C-Z nrPDB Length = 358 Score = 31.2 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 19/113 (16%), Positives = 43/113 (38%), Gaps = 9/113 (7%) Query: 311 FLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHI 370 L + P + + + + + PE + + +Y++ F + +P Sbjct: 241 VLRLANNPDIVKVIKKIGHYLKMNITVPEDYINGFIRANNTFLYQLV-FDPIKRKLIPLN 299 Query: 371 VTQH------TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDAN 417 + S+ G + D + L ++ D + FE+ D +NPD + A+ Sbjct: 300 AYEDDVDPETLSYAGQYV--DDSIALQIALGNKDINTFEQIDDYNPDTAMPAH 350 >4YXC-B nrPDB Length = 227 Score = 30.8 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 16/153 (10%), Positives = 43/153 (28%), Gaps = 26/153 (16%) Query: 240 EINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAG 299 + I + E + P D L + + N + ++ G Sbjct: 76 RVEHLINPILNSLNEEQPKNNPSDENTGALDDLWADALNEQKATTTKSAADAVFQQLGGG 135 Query: 300 TETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRF 359 + + ++I+ ++ + ++ T I E+ R Sbjct: 136 DVSGAM--------------------QDIDLIMDIPVKLTV----ELGRTRMTIKELLRL 171 Query: 360 SDLLPMGVPHIVTQ--HTSFRGYIIPKDTEVFL 390 + + + + + GY+I + V + Sbjct: 172 TQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 204 >4YXB-D nrPDB Length = 80 Score = 30.5 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 8/48 (16%), Positives = 19/48 (39%), Gaps = 2/48 (4%) Query: 345 KMPYTEAVIYEIQRFSDLLPMGVPHIVTQ--HTSFRGYIIPKDTEVFL 390 ++ T I E+ R + + + + + GY+I + V + Sbjct: 10 ELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 57 >3A4L-A nrPDB Length = 260 Score = 30.1 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 33/226 (14%), Positives = 73/226 (32%), Gaps = 16/226 (7%) Query: 76 VMLCGVEAIREAL---VDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTM 132 V++ G + IRE+ +K E F + ++D + Y VI + N + +RR + Sbjct: 35 VIVLGSDLIRESFPVWKEKYEEFIKKSTYRLIDSALKNYWVIVDDTNYYNSMRRDLINIA 94 Query: 133 RDF--GMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHY 190 + + ++ + + IE K ++ + GK++ + Sbjct: 95 KKYNKNYAIIYLKASLDVLIRRNIERGEKIPNEVIKKMYEKFDEP---------GKKYKW 145 Query: 191 QDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVE 250 D+ FL + F+ I+ + + F + +I+ V Sbjct: 146 -DEPFLIIDTTKDIDFNEIAKKLIEKSKEIPKFY-VLEENKNKNNNISDKIDKETRKIVS 203 Query: 251 KHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLF 296 ++ ++ K L +K E + L Sbjct: 204 EYIKSKKLDKDKIKEVVELRKEFLKKIKKMEEVDADRVLKEFKDLL 249 >5L9W-B nrPDB Length = 732 Score = 29.7 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 15/89 (16%), Positives = 32/89 (35%), Gaps = 4/89 (4%) Query: 246 GHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHS----EFSHQNLNLNTLSLFFAGTE 301 G V + R + P LI+ L+ +E+ ++ +++ L G Sbjct: 115 GQRVAERRNIAVQNKPLPLIERDLILGVRERIDSSGSVVRPLDEEDVRTKLRMLMDRGAR 174 Query: 302 TTSTTLRYGFLLMLKYPHVAERVYREIEQ 330 +L + F+ V E + E ++ Sbjct: 175 AIVVSLLWSFMNPAHEKRVREIIREEYKE 203 >4B2T-H nrPDB Length = 543 Score = 29.3 bits (64), Expect = 3.7, Method: Composition-based stats. Identities = 20/126 (15%), Positives = 32/126 (25%), Gaps = 23/126 (18%) Query: 281 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 340 ++L ++ +T+ L V R E IG R Sbjct: 312 GRVPEEDLKRTMMAC-GGSIQTSVNALSS---------DVLGRCQVFEETQIGGERYNFF 361 Query: 341 HDRAKMPY--------TEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLIL 392 K E + E +R M V + + G + + L Sbjct: 362 TGCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAG-----GGAIEMEL 416 Query: 393 STALHD 398 S L D Sbjct: 417 SKYLRD 422 >3RFT-A nrPDB Length = 267 Score = 29.3 bits (64), Expect = 4.4, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 21/55 (38%), Gaps = 11/55 (20%) Query: 390 LILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARA 444 ++ +++ H Y+ + + PD +G G C GE +AR Sbjct: 106 IVFASSNHTIGYYPQTERLGPDVPARPDGL-----------YGVSKCFGENLARM 149 >2KC5-A nrPDB Length = 162 Score = 28.5 bits (62), Expect = 7.0, Method: Composition-based stats. Identities = 19/88 (21%), Positives = 31/88 (35%), Gaps = 10/88 (11%) Query: 349 TEAVIYEIQRFS----DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEK 404 +A EI R S L +P V+ T F G + + +A+ F Sbjct: 16 VQAAFEEIARRSMHDLSFLHPSMPVYVSDFTLFEGQW--TGCVITPWMLSAV----IFPG 69 Query: 405 PDAFNPDHFLDANGALKKTEAFIPFSLG 432 PD P + L+ + F++G Sbjct: 70 PDQLWPLRKVSEKIGLQLPYGTMTFTVG 97 >4R1I-A nrPDB Length = 522 Score = 28.1 bits (61), Expect = 9.9, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 27/83 (32%) Query: 71 GPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVT 130 G VV L + + + L + F+G + V G G+ +G ++R Sbjct: 66 GLIHVVSLLDADGLIKILTHTVKNFTGFAPLGTVLVSLLGVGIAEKSGLISALMRLLLTK 125 Query: 131 TMRDFGMGKRSVEERIQEEAQCL 153 + R + A L Sbjct: 126 SPRKLTTFMVVFTGILSNTASEL 148 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.130 0.339 Lambda K H 0.267 0.0400 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,348,006 Number of Sequences: 36641 Number of extensions: 693800 Number of successful extensions: 3210 Number of sequences better than 10.0: 179 Number of HSP's better than 10.0 without gapping: 230 Number of HSP's successfully gapped in prelim test: 87 Number of HSP's that attempted gapping in prelim test: 2304 Number of HSP's gapped (non-prelim): 345 length of query: 491 length of database: 10,336,785 effective HSP length: 101 effective length of query: 390 effective length of database: 6,636,044 effective search space: 2588057160 effective search space used: 2588057160 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.0 bits) S2: 61 (28.1 bits)