BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P19784 (350 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6HMD-A nrPDB 726 0.0 4MD7-E nrPDB 562 e-161 6EII-A nrPDB 550 e-157 2PVN-A nrPDB 474 e-134 6O6Q-A nrPDB 442 e-125 5XVU-A nrPDB 409 e-114 4LFI-A nrPDB 387 e-108 5Z33-A nrPDB 157 5e-39 4EWQ-A nrPDB 148 3e-36 1V0B-A nrPDB 148 4e-36 3EB0-A nrPDB 147 8e-36 4E7W-A nrPDB 146 1e-35 3OHT-A nrPDB 145 2e-35 3GC9-A nrPDB 145 3e-35 4MYG-A nrPDB 144 5e-35 2BPM-A nrPDB 144 8e-35 1CM8-A nrPDB 143 1e-34 4AU8-A nrPDB 143 1e-34 3NIZ-A nrPDB 139 2e-33 3OZ6-A nrPDB 139 2e-33 4KRC-A nrPDB 138 4e-33 4QNY-A nrPDB 136 1e-32 5AIR-A nrPDB 136 1e-32 1UA2-A nrPDB 135 2e-32 2F9G-A nrPDB 135 3e-32 6GU6-A nrPDB 134 8e-32 5NGU-A nrPDB 133 9e-32 4QTB-A nrPDB 130 1e-30 5G6V-A nrPDB 128 5e-30 6DTL-A nrPDB 128 5e-30 4IC8-A nrPDB 127 7e-30 3GC0-A nrPDB 126 1e-29 5EFQ-A nrPDB 125 2e-29 4ZSG-A nrPDB 124 6e-29 1G3N-A nrPDB 123 1e-28 3E3P-A nrPDB 122 3e-28 4AGU-A nrPDB 121 4e-28 4NST-A nrPDB 121 5e-28 4BGQ-A nrPDB 120 1e-27 3MIA-A nrPDB 120 1e-27 4BBM-A nrPDB 118 5e-27 3PG1-A nrPDB 115 3e-26 3NIE-A nrPDB 112 3e-25 3ZDU-A nrPDB 111 5e-25 4O2Z-A nrPDB 110 1e-24 2I6L-A nrPDB 108 3e-24 3RP9-A nrPDB 107 1e-23 3N9X-A nrPDB 104 5e-23 3E7O-A nrPDB 104 6e-23 5JN2-A nrPDB 102 2e-22 5ZTN-A nrPDB 102 3e-22 1JNK-A nrPDB 101 4e-22 2XS0-A nrPDB 101 6e-22 3LIJ-A nrPDB 101 6e-22 3FI2-A nrPDB 100 7e-22 5AWM-A nrPDB 100 9e-22 2W96-B nrPDB 100 1e-21 3NCG-A nrPDB 100 1e-21 5Y86-A nrPDB 99 2e-21 4F9B-A nrPDB 99 3e-21 3DFA-A nrPDB 98 5e-21 6FDY-U nrPDB 97 7e-21 3MA6-A nrPDB 96 2e-20 4CRL-A nrPDB 96 3e-20 4NIF-A nrPDB 96 3e-20 2VN9-A nrPDB 95 4e-20 2X4F-A nrPDB 94 6e-20 4UZD-A nrPDB 94 6e-20 3D2K-A nrPDB 94 7e-20 3MN3-A nrPDB 94 7e-20 3Q5I-A nrPDB 94 8e-20 3TAC-A nrPDB 94 9e-20 2QNJ-A nrPDB 93 2e-19 2HW6-A nrPDB 93 2e-19 3DXN-A nrPDB 93 2e-19 3HZT-A nrPDB 92 3e-19 2Y7J-A nrPDB 92 3e-19 4RLP-A nrPDB 92 4e-19 4L42-A nrPDB 92 5e-19 1KOB-A nrPDB 91 6e-19 3F3Z-A nrPDB 91 7e-19 4JG6-A nrPDB 90 1e-18 5ES1-A nrPDB 90 1e-18 4MVF-A nrPDB 90 1e-18 5KZ7-A nrPDB 90 2e-18 4RGJ-A nrPDB 89 2e-18 5FG8-A nrPDB 89 2e-18 2VZ6-A nrPDB 89 3e-18 2BDW-A nrPDB 89 3e-18 3BHH-A nrPDB 89 3e-18 3KK8-A nrPDB 89 3e-18 5U6Y-A nrPDB 89 3e-18 3KN6-A nrPDB 88 5e-18 5UNP-A nrPDB 88 7e-18 4C0T-A nrPDB 86 2e-17 6CMJ-A nrPDB 86 2e-17 2HAK-A nrPDB 86 3e-17 3SOA-A nrPDB 86 3e-17 3ORZ-A nrPDB 86 3e-17 5IG1-A nrPDB 86 3e-17 4CZT-A nrPDB 85 4e-17 6QAU-A nrPDB 85 4e-17 3UTO-A nrPDB 85 4e-17 1KOA-A nrPDB 85 5e-17 4D2V-A nrPDB 85 5e-17 6C9D-A nrPDB 85 5e-17 4I6B-A nrPDB 85 6e-17 1ZWS-A nrPDB 84 8e-17 3RAW-A nrPDB 84 1e-16 4YZB-A nrPDB 84 1e-16 6CKI-A nrPDB 84 1e-16 5WAX-A nrPDB 84 1e-16 2V7O-A nrPDB 84 1e-16 5YKS-A nrPDB 83 1e-16 4YNZ-A nrPDB 83 2e-16 5TUR-A nrPDB 83 2e-16 2J90-A nrPDB 83 2e-16 3BGP-A nrPDB 82 3e-16 4B8L-A nrPDB 82 3e-16 2YAB-A nrPDB 82 3e-16 4RC3-A nrPDB 82 4e-16 2A27-A nrPDB 82 4e-16 2WO6-A nrPDB 82 4e-16 1TKI-A nrPDB 81 6e-16 2JD5-A nrPDB 81 6e-16 2WQN-A nrPDB 80 1e-15 5JZN-A nrPDB 80 1e-15 2OZA-A nrPDB 80 1e-15 1NY3-A nrPDB 80 2e-15 1PHK-A nrPDB 80 2e-15 6FYV-A nrPDB 79 2e-15 4WNO-A nrPDB 79 2e-15 2Z7Q-A nrPDB 79 2e-15 5XZW-A nrPDB 79 3e-15 2YCR-A nrPDB 79 3e-15 3KA0-A nrPDB 79 3e-15 2BRG-A nrPDB 79 3e-15 4CQG-A nrPDB 79 4e-15 6FD3-A nrPDB 79 4e-15 1FOT-A nrPDB 78 5e-15 4CFF-A nrPDB 78 5e-15 2W4O-A nrPDB 78 6e-15 5EZV-A nrPDB 78 6e-15 5UUU-A nrPDB 78 6e-15 4D28-A nrPDB 78 7e-15 5X8I-B nrPDB 78 7e-15 4JXF-A nrPDB 77 8e-15 4X7Q-B nrPDB 77 8e-15 5YV8-A nrPDB 77 8e-15 5D9K-A nrPDB 77 9e-15 3PVW-A nrPDB 77 9e-15 3A8W-A nrPDB 77 9e-15 3HKO-A nrPDB 77 1e-14 5F9E-A nrPDB 77 1e-14 4B6L-A nrPDB 77 1e-14 1U5R-A nrPDB 77 1e-14 3I6U-A nrPDB 77 2e-14 2GCD-A nrPDB 76 2e-14 4PDS-A nrPDB 76 2e-14 3H4J-B nrPDB 76 2e-14 2YZA-A nrPDB 75 3e-14 4FG9-A nrPDB 75 5e-14 5J5T-A nrPDB 75 5e-14 3FXW-A nrPDB 74 7e-14 4AF3-A nrPDB 74 1e-13 3LM0-A nrPDB 74 1e-13 3GUB-A nrPDB 74 1e-13 2XNP-A nrPDB 74 1e-13 2JDO-A nrPDB 73 2e-13 3ZUT-A nrPDB 73 2e-13 2JC6-A nrPDB 73 2e-13 3Q53-A nrPDB 72 3e-13 4REW-A nrPDB 72 4e-13 3TXO-A nrPDB 72 5e-13 4FIE-A nrPDB 72 5e-13 3UC3-A nrPDB 72 5e-13 3ORP-A nrPDB 72 5e-13 3LLT-A nrPDB 71 6e-13 6BDL-A nrPDB 71 7e-13 3HDN-A nrPDB 71 7e-13 4JDH-A nrPDB 71 8e-13 4CFH-A nrPDB 71 8e-13 4IAN-A nrPDB 71 8e-13 2Q0N-A nrPDB 70 9e-13 4TNB-A nrPDB 70 1e-12 4XBR-A nrPDB 70 1e-12 3UDB-A nrPDB 70 1e-12 2WTK-C nrPDB 70 1e-12 4RED-A nrPDB 70 1e-12 3NYO-A nrPDB 70 2e-12 6HXF-B nrPDB 70 2e-12 3DLS-A nrPDB 69 2e-12 6CQF-A nrPDB 69 2e-12 5KCV-A nrPDB 69 3e-12 3MV5-A nrPDB 69 3e-12 1VZO-A nrPDB 69 3e-12 5N23-A nrPDB 69 3e-12 4KS7-A nrPDB 68 5e-12 5FQD-C nrPDB 68 5e-12 4EQM-A nrPDB 68 6e-12 2JAM-A nrPDB 67 9e-12 6E9W-A nrPDB 67 1e-11 5DYK-A nrPDB 67 1e-11 6DBM-A nrPDB 67 1e-11 3M42-A nrPDB 67 1e-11 3QA8-A nrPDB 67 2e-11 1ZXE-A nrPDB 66 2e-11 4WB7-A nrPDB 66 2e-11 6ED6-A nrPDB 66 2e-11 6CCF-A nrPDB 66 2e-11 4OLI-A nrPDB 66 3e-11 5D7A-A nrPDB 65 3e-11 5LOH-A nrPDB 65 3e-11 4QMW-A nrPDB 65 3e-11 2XIK-A nrPDB 65 3e-11 5FET-A nrPDB 65 3e-11 5X3F-B nrPDB 65 4e-11 3IS5-A nrPDB 65 6e-11 4KIK-B nrPDB 65 6e-11 2UV2-A nrPDB 65 6e-11 5TQX-A nrPDB 64 9e-11 2PMN-X nrPDB 64 9e-11 3OMV-A nrPDB 64 1e-10 4YHJ-A nrPDB 64 1e-10 4X3F-A nrPDB 64 1e-10 5HI2-A nrPDB 64 1e-10 4NFN-A nrPDB 63 2e-10 6E2O-A nrPDB 63 2e-10 4BTK-A nrPDB 63 2e-10 4OW8-A nrPDB 63 2e-10 4AW2-A nrPDB 63 2e-10 3PFQ-A nrPDB 63 2e-10 6B2Q-A nrPDB 63 2e-10 2OU7-A nrPDB 63 2e-10 3TKU-A nrPDB 63 2e-10 3DB8-A nrPDB 63 2e-10 4J52-A nrPDB 63 2e-10 2I0E-A nrPDB 63 2e-10 4FZF-B nrPDB 63 2e-10 3C51-A nrPDB 63 2e-10 4RA4-A nrPDB 62 3e-10 6HV0-A nrPDB 62 4e-10 5O2B-A nrPDB 62 4e-10 4PL5-B nrPDB 62 5e-10 2F57-A nrPDB 62 5e-10 5O2C-A nrPDB 61 6e-10 2PZI-A nrPDB 61 6e-10 3SV0-A nrPDB 61 7e-10 6GVJ-A nrPDB 61 7e-10 5HIE-A nrPDB 61 7e-10 4U41-A nrPDB 61 7e-10 4E93-A nrPDB 61 7e-10 4PWN-A nrPDB 61 8e-10 3HMP-A nrPDB 60 1e-09 2ZMD-A nrPDB 60 1e-09 5X5O-A nrPDB 60 1e-09 4E20-A nrPDB 60 1e-09 6DBN-A nrPDB 60 1e-09 4Y12-A nrPDB 60 1e-09 4C59-A nrPDB 60 1e-09 5AP3-A nrPDB 60 2e-09 4FR4-A nrPDB 60 2e-09 4HVI-A nrPDB 60 2e-09 3ALO-A nrPDB 59 2e-09 4WUA-A nrPDB 59 3e-09 3VN9-A nrPDB 59 3e-09 3COM-A nrPDB 59 3e-09 5H2U-A nrPDB 59 3e-09 3DAK-A nrPDB 59 4e-09 3CJF-A nrPDB 59 5e-09 4APC-A nrPDB 57 9e-09 4M66-A nrPDB 57 9e-09 4LQP-A nrPDB 57 1e-08 4IDT-A nrPDB 57 1e-08 4TN6-A nrPDB 57 1e-08 2X7G-A nrPDB 57 2e-08 5X02-A nrPDB 57 2e-08 2VD5-A nrPDB 57 2e-08 4XUF-A nrPDB 56 2e-08 3A4O-X nrPDB 56 2e-08 4G3E-A nrPDB 56 2e-08 4H1J-A nrPDB 56 2e-08 2DQ7-X nrPDB 56 3e-08 3FME-A nrPDB 56 3e-08 5TE0-A nrPDB 55 4e-08 5DBX-A nrPDB 55 5e-08 4LG4-A nrPDB 55 5e-08 5GRN-A nrPDB 54 7e-08 4EBW-A nrPDB 54 7e-08 6AO5-A nrPDB 54 8e-08 2CMW-A nrPDB 54 8e-08 2CHL-A nrPDB 54 8e-08 6CTH-A nrPDB 54 8e-08 4AN9-A nrPDB 54 9e-08 5KKR-C nrPDB 54 9e-08 3EQC-A nrPDB 54 1e-07 3GQL-A nrPDB 54 1e-07 5A46-A nrPDB 54 1e-07 3TT0-A nrPDB 54 1e-07 2J0K-A nrPDB 54 1e-07 6BXI-A nrPDB 54 1e-07 2BUJ-A nrPDB 53 2e-07 4CSV-A nrPDB 53 2e-07 2C47-A nrPDB 53 2e-07 6GQK-A nrPDB 53 2e-07 4M7I-A nrPDB 52 3e-07 5O0Y-A nrPDB 52 3e-07 2W1I-A nrPDB 52 4e-07 5B2L-A nrPDB 52 4e-07 3BEA-A nrPDB 52 5e-07 5VD3-A nrPDB 52 5e-07 3G0E-A nrPDB 51 7e-07 4NT4-A nrPDB 51 8e-07 5HVK-A nrPDB 51 8e-07 3IO7-A nrPDB 51 1e-06 2A1A-B nrPDB 50 1e-06 5M07-A nrPDB 50 1e-06 4XEY-B nrPDB 50 1e-06 2OGV-A nrPDB 50 1e-06 2PL0-A nrPDB 50 1e-06 5IKW-A nrPDB 50 1e-06 3KRL-A nrPDB 50 2e-06 4GS6-A nrPDB 50 2e-06 4Y83-A nrPDB 49 2e-06 4TPT-A nrPDB 49 2e-06 5L2Q-C nrPDB 49 2e-06 4JLC-A nrPDB 49 2e-06 4K33-A nrPDB 49 2e-06 2PSQ-A nrPDB 49 2e-06 3PLS-A nrPDB 49 3e-06 4EUU-A nrPDB 49 3e-06 6NPU-A nrPDB 49 3e-06 2FO0-A nrPDB 49 3e-06 4EUT-A nrPDB 49 4e-06 3UIU-A nrPDB 49 4e-06 4RT7-A nrPDB 49 4e-06 5HLW-A nrPDB 48 5e-06 6NT9-A nrPDB 48 6e-06 1CSN-A nrPDB 48 6e-06 6O8B-A nrPDB 48 7e-06 4XCU-A nrPDB 48 7e-06 3PPZ-A nrPDB 48 7e-06 1S9I-A nrPDB 47 8e-06 3DTC-A nrPDB 47 1e-05 4UY9-A nrPDB 47 1e-05 4R7H-A nrPDB 47 1e-05 5EG3-A nrPDB 47 1e-05 2HK5-A nrPDB 47 2e-05 4NEU-A nrPDB 47 2e-05 2RIO-A nrPDB 46 3e-05 6E4F-A nrPDB 46 3e-05 2XYN-A nrPDB 46 3e-05 4XI2-A nrPDB 45 3e-05 5CEK-A nrPDB 45 4e-05 3MDY-A nrPDB 45 5e-05 6DC0-A nrPDB 45 5e-05 4AT3-A nrPDB 45 6e-05 3V5Q-A nrPDB 45 6e-05 4XHH-A nrPDB 44 9e-05 4CRS-A nrPDB 44 9e-05 3MY0-A nrPDB 44 1e-04 4Y93-A nrPDB 44 1e-04 4XHL-A nrPDB 44 1e-04 1AD5-A nrPDB 43 2e-04 4XLV-A nrPDB 43 2e-04 4LRM-A nrPDB 43 2e-04 3C1X-A nrPDB 43 2e-04 4UYA-A nrPDB 43 2e-04 3SOC-A nrPDB 43 2e-04 4CI6-B nrPDB 43 2e-04 4IX6-A nrPDB 43 3e-04 2QLU-A nrPDB 43 3e-04 3QD2-B nrPDB 42 3e-04 5X18-A nrPDB 42 3e-04 4OTD-A nrPDB 42 3e-04 3QUP-A nrPDB 42 4e-04 2WTK-B nrPDB 42 5e-04 3VHK-A nrPDB 41 6e-04 5GNK-A nrPDB 41 7e-04 3LZB-A nrPDB 41 9e-04 3HNG-A nrPDB 41 0.001 2Y4I-B nrPDB 40 0.001 2H34-A nrPDB 40 0.001 4JRN-A nrPDB 40 0.001 5AMN-A nrPDB 40 0.001 4P5Q-A nrPDB 40 0.001 5WNL-A nrPDB 40 0.001 1BYG-A nrPDB 40 0.001 3BBT-B nrPDB 40 0.002 4AZW-A nrPDB 40 0.002 4YFF-A nrPDB 40 0.002 1K9A-A nrPDB 40 0.002 5U6B-A nrPDB 39 0.002 5FM2-A nrPDB 39 0.003 5AR8-A nrPDB 39 0.003 1LUF-A nrPDB 39 0.004 5XD6-A nrPDB 39 0.004 3QGY-A nrPDB 39 0.004 4AZV-A nrPDB 39 0.004 2R2P-A nrPDB 38 0.006 3PP0-A nrPDB 38 0.007 6G4J-A nrPDB 38 0.007 2VWV-A nrPDB 37 0.009 3KUL-B nrPDB 37 0.010 5WNO-A nrPDB 37 0.011 5VO2-A nrPDB 37 0.012 2QKW-B nrPDB 36 0.026 3G2F-A nrPDB 35 0.033 3UIM-A nrPDB 35 0.061 3DKO-A nrPDB 35 0.072 1U59-A nrPDB 34 0.077 5CLR-A nrPDB 34 0.080 1FVR-A nrPDB 34 0.11 3ZZW-A nrPDB 34 0.11 2OZO-A nrPDB 33 0.18 4FL3-A nrPDB 33 0.21 5UIU-A nrPDB 33 0.23 5C26-A nrPDB 32 0.31 4O1O-A nrPDB 32 0.37 5VC6-A nrPDB 32 0.38 6J6I-B nrPDB 32 0.43 2RSV-A nrPDB 31 0.61 5U6C-A nrPDB 31 0.64 2LAV-A nrPDB 31 0.67 4I94-A nrPDB 31 0.73 5LPV-A nrPDB 31 0.78 3SXS-A nrPDB 31 0.79 5LPZ-A nrPDB 31 0.87 5VDK-A nrPDB 30 1.4 3LMG-A nrPDB 30 1.5 5OAT-A nrPDB 30 1.6 6BFN-A nrPDB 30 2.1 5E8V-A nrPDB 30 2.1 5TOS-A nrPDB 29 2.4 4L00-A nrPDB 29 2.8 5UU1-A nrPDB 29 3.8 4NK7-A nrPDB 28 4.5 1JKF-A nrPDB 28 5.8 3IC9-A nrPDB 28 6.1 >6HMD-A nrPDB Length = 365 Score = 726 bits (1875), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/350 (99%), Positives = 349/350 (99%) Query: 1 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 60 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI Sbjct: 16 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 75 Query: 61 TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 120 TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT Sbjct: 76 TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 135 Query: 121 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA Sbjct: 136 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 195 Query: 181 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY Sbjct: 196 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 255 Query: 241 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD Sbjct: 256 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 315 Query: 301 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR 350 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQP ADNAVLSSGLTAAR Sbjct: 316 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPSADNAVLSSGLTAAR 365 >4MD7-E nrPDB Length = 391 Score = 562 bits (1448), Expect = e-161, Method: Compositional matrix adjust. Identities = 289/355 (81%), Positives = 314/355 (88%), Gaps = 7/355 (1%) Query: 1 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 60 M GP SRARVY +VN+ R REYWDYE+HV WGNQDDYQLVRKLGRGKYSEVFEAINI Sbjct: 1 MSGPVP-SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINI 59 Query: 61 TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 120 TNNE+VVVKILKPVKKKKIKRE+KILENLRGG NII L D VKDPVS+TPALVFE++NNT Sbjct: 60 TNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119 Query: 121 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180 DFKQLYQ LTD+DIRFYMYE+LKALDYCHS GIMHRDVKPHNVMIDH+ +KLRLIDWGLA Sbjct: 120 DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 Query: 181 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240 EFYHP QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR+EPFFHG DNY Sbjct: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239 Query: 241 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300 DQLVRIAKVLGTE+LY Y+ KY+I+LDP FNDILG+HSRKRWE F+HSEN+HLVSPEALD Sbjct: 240 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299 Query: 301 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ------SQPCADNAVLSSGLTAA 349 LDKLLRYDHQ RLTA+EAMEHPYFY VVK+Q S P V S+ + + Sbjct: 300 FLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSEPVSSANMMSG 354 >6EII-A nrPDB Length = 352 Score = 550 bits (1418), Expect = e-157, Method: Compositional matrix adjust. Identities = 280/323 (86%), Positives = 301/323 (93%) Query: 8 SRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVV 67 SRARVY +VN+ R EYWDYE+HV WGNQDDYQLVRKLGRGKYSEVFEAINITNNE+VV Sbjct: 30 SRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVV 89 Query: 68 VKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ 127 VKILKPVKKKKIKRE+KILENLRGG NII L D VKDPVS+TPALVFE++NNTDFKQLYQ Sbjct: 90 VKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ 149 Query: 128 ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ 187 LTD+DIRFYMYE+LKALDYCHS GIMHRDVKPHNVMIDH+ +KLRLIDWGLAEFYHP Q Sbjct: 150 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 209 Query: 188 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIA 247 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR+EPFFHG DNYDQLVRIA Sbjct: 210 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 269 Query: 248 KVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLR 307 KVLGTE+LY Y+ KY+I+LDP FNDILG+HSRKRWE F+HSEN+HLVSPEALD LDKLLR Sbjct: 270 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 329 Query: 308 YDHQQRLTAKEAMEHPYFYPVVK 330 YDHQ RLTA+EAMEHPYFY VVK Sbjct: 330 YDHQSRLTAREAMEHPYFYTVVK 352 >2PVN-A nrPDB Length = 352 Score = 474 bits (1219), Expect = e-134, Method: Compositional matrix adjust. Identities = 239/328 (72%), Positives = 282/328 (85%) Query: 1 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 60 +P + S+ARVYA+VN LR +EYWDYEA WG QDDY++VRK+GRGKYSEVFE IN+ Sbjct: 15 VPRGSHMSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINV 74 Query: 61 TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 120 NNE+ ++KILKPVKKKKIKRE+KIL+NL GG NI+KL+D V+D SKTP+L+FEY+NNT Sbjct: 75 NNNEKCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNT 134 Query: 121 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180 DFK LY LTD+DIR+Y+YELLKALDYCHS+GIMHRDVKPHNVMIDH+ +KLRLIDWGLA Sbjct: 135 DFKVLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLA 194 Query: 181 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240 EFYHP +EYNVRVASRYFKGPELLVD Q YDYSLDMWSLGCM A MIFR+EPFF+G DN+ Sbjct: 195 EFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNH 254 Query: 241 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300 DQLV+IAKVLGT+ L YL KY I+LDP ++G+HSRK W F++++N+HLVSPEA+D Sbjct: 255 DQLVKIAKVLGTDGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAID 314 Query: 301 LLDKLLRYDHQQRLTAKEAMEHPYFYPV 328 LDKLLRYDHQ+RLTA EAM HPYF V Sbjct: 315 FLDKLLRYDHQERLTALEAMTHPYFQQV 342 >6O6Q-A nrPDB Length = 335 Score = 442 bits (1138), Expect = e-125, Method: Compositional matrix adjust. Identities = 207/321 (64%), Positives = 260/321 (80%), Gaps = 1/321 (0%) Query: 8 SRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVV 67 S +RVYA+V S + + YWDY+ W Q++Y+++RKLGRGKYSEVF I++ E+VV Sbjct: 11 SVSRVYADVLSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVV 70 Query: 68 VKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ 127 +K+LKPVK+KKIKRE+ IL+NL G NII ++D V++P SKTP L+FE+INN DF+ LY Sbjct: 71 IKVLKPVKRKKIKREISILKNLVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSLYP 130 Query: 128 ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ 187 TD+DIRFYMYELLKALDY HS GIMHRDVKPHNVMIDH +K LRLIDWGLAE+YHP Sbjct: 131 TFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGT 190 Query: 188 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIA 247 EYNVRVASRYFKGPELLVDY++YDYSLDMWS GCMLASM+F +EPFFHG+ N DQLV+I Sbjct: 191 EYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIV 250 Query: 248 KVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLR 307 +VLG++ YL+KY+I L + DI G +++++W F++ N+ LVS E LDL+D+LLR Sbjct: 251 RVLGSKNFKKYLEKYNISLGEEYEDI-GYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLR 309 Query: 308 YDHQQRLTAKEAMEHPYFYPV 328 YDHQ+RLTAKEAM+H YF P+ Sbjct: 310 YDHQERLTAKEAMKHAYFDPI 330 >5XVU-A nrPDB Length = 332 Score = 409 bits (1050), Expect = e-114, Method: Compositional matrix adjust. Identities = 205/323 (63%), Positives = 260/323 (80%) Query: 11 RVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI 70 + YA+VN + +EY+DY+ W + Y++++K+GRGKYSEVF + N +K+ Sbjct: 4 KFYADVNIHKPKEYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKV 63 Query: 71 LKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILT 130 LKPVKKKKIKRE+KIL+NL GG NIIKL+D VKDPV+KTP+L+FEYINN DFK LY T Sbjct: 64 LKPVKKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTLYPKFT 123 Query: 131 DFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN 190 D DIR+Y+Y++LKALDYCHS+GIMHRDVKPHN+MIDH+ +++RLI WGLAEFYHP QEYN Sbjct: 124 DKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYN 183 Query: 191 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVL 250 VRVASRY+KGPELL+D Q+YDYSLD+WSLGCMLA MIF++EPFF G DNYDQLV+IAKVL Sbjct: 184 VRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVL 243 Query: 251 GTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDH 310 GTE+L+ YLKKY+I L PH+ +ILG++ RK W +F+ N + E +DL+DK+L YDH Sbjct: 244 GTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDH 303 Query: 311 QQRLTAKEAMEHPYFYPVVKEQS 333 +R+ KEAMEHPYF V +E + Sbjct: 304 AKRIAPKEAMEHPYFREVREESA 326 >4LFI-A nrPDB Length = 374 Score = 387 bits (995), Expect = e-108, Method: Compositional matrix adjust. Identities = 202/361 (55%), Positives = 247/361 (68%), Gaps = 41/361 (11%) Query: 8 SRARVYAEVNSLRSREYWDYEAHVPSWG-NQDDYQLVRKLGRGKYSEVFEAINITNNERV 66 S ARVY +N R+ EYWDYE V W N DY++ K+GRGKYSEVF+ + + + ++ Sbjct: 9 SEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKI 68 Query: 67 VVKI---------------LKPVKKKKI--------------KREVKILENLR------- 90 V+K+ L + +K+ ++ +L+ +R Sbjct: 69 VIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQP 128 Query: 91 --GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYC 148 G NII L D +KDP+SKTPALVFEY++N DF+ LY LTD +IRFYM+ELLKALDYC Sbjct: 129 HNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYC 188 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQ 208 HS GIMHRDVKPHNVMIDH+ KKLRLIDWGLAEFYH EYNVRVASR+FKGPELLVDY+ Sbjct: 189 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 248 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 MYDYSLD+WS G MLASMIF+REPFFHG N DQLV+I KVLGT + YL KY I L Sbjct: 249 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 308 Query: 269 HFNDILGQHSRKRWENFIHSENRHLV-SPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 F D + Q+ RK W FI+ N+HL + E +DL+D LLRYDHQ+RLTAKEAM HP+F P Sbjct: 309 EFYD-MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 367 Query: 328 V 328 + Sbjct: 368 I 368 >5Z33-A nrPDB Length = 425 Score = 157 bits (398), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 99/303 (32%), Positives = 168/303 (55%), Gaps = 26/303 (8%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK-----REVKILENLRGGTN 94 Y + ++LG+G Y V A+N +E V +K + V KKI RE+K+L++ RG N Sbjct: 33 YTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRN 92 Query: 95 IIKLIDT-VKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHS 150 I L D + P + ++E + D + Q LTD + ++Y++L L Y HS Sbjct: 93 ITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHS 152 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR-----VASRYFKGPELLV 205 ++HRD+KP N++++ +L++ D+GLA + E N VA+R+++ PE+++ Sbjct: 153 ANVLHRDLKPGNLLVN-ADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEIML 211 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT--EELYGYLKKYH 263 +Q Y ++D+WS+GC+LA ++ R PFF G+D DQL +I +LGT EE L + Sbjct: 212 SFQSYTKAIDVWSVGCILAELLGGR-PFFKGRDYVDQLNQILHILGTPNEET---LSRIG 267 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 + L ++K + + N P+ALDLLD++L +D R++ ++A+EHP Sbjct: 268 SPRAQEYVRNLPFMAKKPFPTLFPNAN-----PDALDLLDRMLAFDPSSRISVEQALEHP 322 Query: 324 YFY 326 Y + Sbjct: 323 YLH 325 >4EWQ-A nrPDB Length = 383 Score = 148 bits (374), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 106/346 (30%), Positives = 183/346 (52%), Gaps = 38/346 (10%) Query: 12 VYAEVNSLRSR-EYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI 70 +Y + N+ + R ++ E + W + YQ + +G G Y V A + RV VK Sbjct: 18 LYFQSNASQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKK 77 Query: 71 L-KP----VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINN------ 119 L +P + K+ RE+++L++++ N+I L+D TPA E N+ Sbjct: 78 LSRPFQSIIHAKRTYRELRLLKHMKH-ENVIGLLDVF------TPARSLEEFNDVYLVTH 130 Query: 120 ---TDFKQLY--QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRL 174 D + Q LTD ++F +Y++L+ L Y HS I+HRD+KP N+ ++ + +L++ Sbjct: 131 LMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKI 189 Query: 175 IDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFF 234 +D+GLA H E VA+R+++ PE+++++ Y+ ++D+WS+GC++A ++ R F Sbjct: 190 LDFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRT-LF 246 Query: 235 HGQDNYDQLVRIAKVLGT--EELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRH 292 G D+ DQL I +++GT EL LKK + ++ L Q + + N N Sbjct: 247 PGTDHIDQLKLILRLVGTPGAEL---LKKISSESARNYIQSLTQMPKMNFANVFIGAN-- 301 Query: 293 LVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCAD 338 P A+DLL+K+L D +R+TA +A+ H YF +P AD Sbjct: 302 ---PLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAD 344 >1V0B-A nrPDB Length = 288 Score = 148 bits (373), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 97/302 (32%), Positives = 165/302 (54%), Gaps = 33/302 (10%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK----REVKILENLRGGT 93 + Y + K+G G Y V++A N + KI + + I RE+ IL+ L+ + Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKH-S 60 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCH 149 NI+KL D + K LVFE+++ D K+L + L + ++ +LL + YCH Sbjct: 61 NIVKLYDVIH--TKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCH 117 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLVDYQ 208 + ++HRD+KP N++I+ ++ +L++ D+GLA F P ++Y V + +++ P++L+ + Sbjct: 118 DRRVLHRDLKPQNLLIN-REGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSK 176 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY-----LKKYH 263 Y ++D+WS+GC+ A M+ P F G DQL+RI ++LGT + L KY Sbjct: 177 KYSTTIDIWSVGCIFAEMV-NGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKY- 234 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 DP+F + WE+F+ + +DLL K+L+ D QR+TAK+A+EH Sbjct: 235 ---DPNFT----VYEPLPWESFLKG-----LDESGIDLLSKMLKLDPNQRITAKQALEHA 282 Query: 324 YF 325 YF Sbjct: 283 YF 284 >3EB0-A nrPDB Length = 383 Score = 147 bits (371), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 98/334 (29%), Positives = 165/334 (49%), Gaps = 65/334 (19%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVK-ILKPVKKKKIKREVKILENLRGGTNIIKL 98 Y L + LG G + V E +I + +R +K +L+ + K RE+ I++ L NIIKL Sbjct: 9 YSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN--RELDIMKVL-DHVNIIKL 65 Query: 99 ID---TVKDPVSKTPA---------------------------------LVFEYINNTDF 122 +D T D K P ++ EY+ +T Sbjct: 66 VDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDT-- 123 Query: 123 KQLYQILTDFD----------IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL 172 L+++L F I Y+Y+L +A+ + HS GI HRD+KP N++++ + L Sbjct: 124 --LHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTL 181 Query: 173 RLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREP 232 +L D+G A+ P++ + SR+++ PEL++ Y S+D+WS+GC+ +I + P Sbjct: 182 KLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGK-P 240 Query: 233 FFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDI-LGQHSRKRWENFIHSENR 291 F G+ + DQLVRI +++GT K+ I ++PH+ ++ K W + Sbjct: 241 LFSGETSIDQLVRIIQIMGTPT-----KEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTP 295 Query: 292 HLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 L A+DLL+++LRY+ R+ EAM HP+F Sbjct: 296 SL----AIDLLEQILRYEPDLRINPYEAMAHPFF 325 >4E7W-A nrPDB Length = 394 Score = 146 bits (369), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 102/307 (33%), Positives = 163/307 (53%), Gaps = 44/307 (14%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLI 99 Y + +G G + VF+A + ++E + K+L+ K+ RE++I+ ++ N++ L Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDEVAIKKVLQ--DKRFKNRELQIMRIVKH-PNVVDLK 98 Query: 100 DTV------KDPVSKTPALVFEYINNTDFK------QLYQILTDFDIRFYMYELLKALDY 147 KD V LV EY+ T ++ +L Q + I+ YMY+LL++L Y Sbjct: 99 AFFYSNGDKKDEVFLN--LVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAY 156 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR-VASRYFKGPELLVD 206 HS GI HRD+KP N+++D L+LID+G A+ A E NV + SRY++ PEL+ Sbjct: 157 IHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILI-AGEPNVSYICSRYYRAPELIFG 215 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT---EELY----GYL 259 Y ++D+WS GC++A ++ + +P F G+ DQLV I KVLGT E++ Y+ Sbjct: 216 ATNYTTNIDIWSTGCVMAELM-QGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYM 274 Query: 260 KKYHIDLDPH-FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE 318 + + PH F+ + R P+A+DL+ +LL Y RLTA E Sbjct: 275 EHKFPQIRPHPFSKVF----------------RPRTPPDAIDLISRLLEYTPSARLTAIE 318 Query: 319 AMEHPYF 325 A+ HP+F Sbjct: 319 ALCHPFF 325 >3OHT-A nrPDB Length = 389 Score = 145 bits (367), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 98/336 (29%), Positives = 179/336 (53%), Gaps = 34/336 (10%) Query: 6 AGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNER 65 AGS A + + R ++ E + W + YQ + +G G Y V + ++ + + Sbjct: 20 AGSAAAPFTMSHKERPT-FYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLK 78 Query: 66 VVVKIL-KP----VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINN- 119 + VK L +P + K+ RE+++L++++ N+I L+D TPA E N+ Sbjct: 79 IAVKKLSRPFQSIIHAKRTYRELRLLKHMKH-ENVIGLLDVF------TPATSLEEFNDV 131 Query: 120 --------TDFKQLY--QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ 169 D + Q LTD ++F +Y++L+ L Y HS I+HRD+KP N+ ++ + Sbjct: 132 YLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-ED 190 Query: 170 KKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR 229 +L+++D+GLA H E VA+R+++ PE+++++ Y+ ++D+WS+GC++A ++ Sbjct: 191 CELKILDFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTG 248 Query: 230 REPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSE 289 R F G D+ +QL +I ++ GT + + + N + R + FI + Sbjct: 249 RT-LFPGTDHINQLQQIMRLTGTPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGA- 306 Query: 290 NRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 +P A+DLL+K+L D +R+TA EA+ HPYF Sbjct: 307 -----NPLAVDLLEKMLVLDTDKRITASEALAHPYF 337 >3GC9-A nrPDB Length = 370 Score = 145 bits (365), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 107/365 (29%), Positives = 181/365 (49%), Gaps = 71/365 (19%) Query: 1 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 60 M GP AG ++ E + W Q +R +G G Y V A + Sbjct: 7 MSGPRAG----------------FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDA 50 Query: 61 TNNERVVVKIL-KP----VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFE 115 ++V VK L +P + ++ RE+++L++L+ N+I L+D TPA E Sbjct: 51 RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKH-ENVIGLLDVF------TPATSIE 103 Query: 116 YINNTDFKQLY----------------QILTDFDIRFYMYELLKALDYCHSKGIMHRDVK 159 DF ++Y Q L+D ++F +Y+LL+ L Y HS GI+HRD+K Sbjct: 104 -----DFSEVYLVTTLMGADLNNIVKSQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLK 158 Query: 160 PHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSL 219 P NV ++ + +LR++D+GLA +E VA+R+++ PE+++++ Y+ ++D+WS+ Sbjct: 159 PSNVAVN-EDSELRILDFGLAR--QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSV 215 Query: 220 GCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSR 279 GC++A ++ + + F G D DQL RI +V+GT K I +H+R Sbjct: 216 GCIMAELL-QGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK------------ISSEHAR 262 Query: 280 KRWENFIHSENRHLVS------PEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQS 333 ++ + L S P A+DLL ++L D QR++A EA+ H YF + Sbjct: 263 TYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPED 322 Query: 334 QPCAD 338 +P A+ Sbjct: 323 EPEAE 327 >4MYG-A nrPDB Length = 372 Score = 144 bits (364), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 96/330 (29%), Positives = 179/330 (54%), Gaps = 34/330 (10%) Query: 14 AEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-K 72 + ++ +R + ++ + + +W Y +G G Y V AI+ + E+V +K L + Sbjct: 19 SHMSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR 78 Query: 73 PVKK----KKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPA----------LVFEYIN 118 P + K+ RE+ +L++++ N+I L+D TPA LV ++ Sbjct: 79 PFQSEIFAKRAYRELLLLKHMQH-ENVIGLLDVF------TPASSLRNFYDFYLVMPFMQ 131 Query: 119 NTDFKQLYQI-LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDW 177 TD +++ + ++ I++ +Y++LK L Y HS G++HRD+KP N+ ++ + +L+++D+ Sbjct: 132 -TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDF 189 Query: 178 GLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQ 237 GLA H E V +R+++ PE+++ + Y+ ++D+WS+GC++A M+ + F G+ Sbjct: 190 GLAR--HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT-LFKGK 246 Query: 238 DNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPE 297 D DQL +I KV G +++K + + L Q RK + SP+ Sbjct: 247 DYLDQLTQILKVTGVPGT-EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQ 300 Query: 298 ALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 A DLL+K+L D +RLTA +A+ HP+F P Sbjct: 301 AADLLEKMLELDVDKRLTAAQALTHPFFEP 330 >2BPM-A nrPDB Length = 309 Score = 144 bits (362), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 99/308 (32%), Positives = 162/308 (52%), Gaps = 29/308 (9%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVKILENL 89 + +++Q V K+G G Y V++A N E V +K ++ V I RE+ +L+ L Sbjct: 5 DMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKEL 63 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--QILTDFD---IRFYMYELLKA 144 NI+KL+D + LVFE+++ D K+ LT I+ Y+++LL+ Sbjct: 64 -NHPNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQG 119 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPEL 203 L +CHS ++HRD+KP N++I+ + ++L D+GLA F P + Y V + +++ PE+ Sbjct: 120 LAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 178 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT-EELYGYLKKY 262 L+ + Y ++D+WSLGC+ A M+ RR F G DQL RI + LGT +E+ Sbjct: 179 LLGCKYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 237 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 D P F +W S+ + + LL ++L YD +R++AK A+ H Sbjct: 238 MPDYKPSF---------PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAH 288 Query: 323 PYFYPVVK 330 P+F V K Sbjct: 289 PFFQDVTK 296 >1CM8-A nrPDB Length = 367 Score = 143 bits (361), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 97/329 (29%), Positives = 181/329 (55%), Gaps = 35/329 (10%) Query: 24 YWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-KPVKK----KK 78 ++ E +W + Y+ ++ +G G Y V A++ +V +K L +P + K+ Sbjct: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70 Query: 79 IKREVKILENLRGGTNIIKLIDTVKDPVSKTPA----------LVFEYINNTDFKQL--Y 126 RE+++L+++R N+I L+D TP LV ++ TD +L + Sbjct: 71 AYRELRLLKHMRH-ENVIGLLDVF------TPDETLDDFTDFYLVMPFMG-TDLGKLMKH 122 Query: 127 QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA 186 + L + I+F +Y++LK L Y H+ GI+HRD+KP N+ ++ + +L+++D+GLA Sbjct: 123 EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLAR--QAD 179 Query: 187 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRI 246 E V +R+++ PE+++++ Y ++D+WS+GC++A MI + F G D+ DQL I Sbjct: 180 SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKT-LFKGSDHLDQLKEI 238 Query: 247 AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLL 306 KV GT ++++ D ++ L + +K + + + + SP A++LL+K+L Sbjct: 239 MKVTGTPPAE-FVQRLQSDEAKNYMKGLPELEKKDFASILTN-----ASPLAVNLLEKML 292 Query: 307 RYDHQQRLTAKEAMEHPYFYPVVKEQSQP 335 D +QR+TA EA+ HPYF + + +P Sbjct: 293 VLDAEQRVTAGEALAHPYFESLHDTEDEP 321 >4AU8-A nrPDB Length = 296 Score = 143 bits (360), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 98/305 (32%), Positives = 163/305 (53%), Gaps = 28/305 (9%) Query: 33 SWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVKIL 86 + G+Q Y+ + K+G G Y VF+A N +E V +K ++ V + RE+ +L Sbjct: 2 AMGSQK-YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSAL-REICLL 59 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYELLK 143 + L+ NI++L D + K LVFE+ + K D D ++ ++++LLK Sbjct: 60 KELKH-KNIVRLHDVLHS--DKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLK 116 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPE 202 L +CHS+ ++HRD+KP N++I+ + +L+L D+GLA F P + Y+ V + +++ P+ Sbjct: 117 GLGFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 175 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG--TEELYGYLK 260 +L ++Y S+DMWS GC+ A + P F G D DQL RI ++LG TEE + + Sbjct: 176 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 235 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 320 K P + + N + N DLL LL+ + QR++A+EA+ Sbjct: 236 KL-----PDYKPYPMYPATTSLVNVVPKLNA-----TGRDLLQNLLKCNPVQRISAEEAL 285 Query: 321 EHPYF 325 +HPYF Sbjct: 286 QHPYF 290 >3NIZ-A nrPDB Length = 311 Score = 139 bits (350), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 93/300 (31%), Positives = 156/300 (52%), Gaps = 22/300 (7%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK----REVKILENLR 90 G + YQ + K+G G Y V++A + + +I + + I RE+ +L+ L Sbjct: 18 GLMEKYQKLEKVGEGTYGVVYKAKDSQGRIVALKRIRLDAEDEGIPSTAIREISLLKELH 77 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY----QILTDFDIRFYMYELLKALD 146 NI+ LID + + LVFE++ D K++ L D I+ Y+Y+LL+ + Sbjct: 78 H-PNIVSLIDVIHS--ERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGVA 133 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLV 205 +CH I+HRD+KP N++I+ L+L D+GLA F P + Y V + +++ P++L+ Sbjct: 134 HCHQHRILHRDLKPQNLLIN-SDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLM 192 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 + Y S+D+WS+GC+ A MI + P F G + DQL +I +LGT + + + Sbjct: 193 GSKKYSTSVDIWSIGCIFAEMITGK-PLFPGVTDDDQLPKIFSILGTPNPREWPQVQELP 251 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 L +K W + I E +DLL +L +D +R++A++AM HPYF Sbjct: 252 L--WKQRTFQVFEKKPWSSIIPG-----FCQEGIDLLSNMLCFDPNKRISARDAMNHPYF 304 >3OZ6-A nrPDB Length = 388 Score = 139 bits (349), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 97/346 (28%), Positives = 174/346 (50%), Gaps = 52/346 (15%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREVKILENLRGGTN 94 Y+LV+KLG+G Y V+++I+ E V VK + ++ RE+ IL L G N Sbjct: 11 YELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHEN 70 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDYCHSKG 152 I+ L++ ++ + LVF+Y+ TD + + IL ++ +Y+L+K + Y HS G Sbjct: 71 IVNLLNVLRADNDRDVYLVFDYME-TDLHAVIRANILEPVHKQYVVYQLIKVIKYLHSGG 129 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR-------------------- 192 ++HRD+KP N++++ + +++ D+GL+ + N+R Sbjct: 130 LLHRDMKPSNILLN-AECHVKVADFGLSRSF-----VNIRRVTNNIPLSINENTENFDDD 183 Query: 193 -------VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR 245 VA+R+++ PE+L+ Y +DMWSLGC+L ++ + P F G +QL R Sbjct: 184 QPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGK-PIFPGSSTMNQLER 242 Query: 246 IAKVL------GTEELYGYLKKYHIDLDPHFNDILGQHSR---KRWENFIHSEN-RHLVS 295 I V+ E + K I+ +I + R +W+N + N + + Sbjct: 243 IIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCN 302 Query: 296 PEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAV 341 EALDLLDKLL+++ +R++A +A++HP+ +P D+ + Sbjct: 303 EEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHII 348 >4KRC-A nrPDB Length = 317 Score = 138 bits (347), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 88/306 (28%), Positives = 165/306 (53%), Gaps = 27/306 (8%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK----REVKILENLRG 91 + ++ + KLG G Y+ V++ +N T V +K +K ++ RE+ +++ L+ Sbjct: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---------IRFYMYELL 142 NI++L D + T LVFE+++N D K+ T + ++++ ++LL Sbjct: 63 -ENIVRLYDVIHTENKLT--LVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGP 201 + L +CH I+HRD+KP N++I+ ++ +L+L D+GLA F P ++ V + +++ P Sbjct: 119 QGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT--EELYGYL 259 ++L+ + Y S+D+WS GC+LA MI + P F G ++ +QL I ++GT E L+ + Sbjct: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 K P +N + Q + + + + +D L LL+ + RL+AK+A Sbjct: 237 TKL-----PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 Query: 320 MEHPYF 325 + HP+F Sbjct: 292 LHHPWF 297 >4QNY-A nrPDB Length = 354 Score = 136 bits (343), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 105/343 (30%), Positives = 168/343 (48%), Gaps = 55/343 (16%) Query: 4 PAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNN 63 PA S A + AEV L R Y L R +G G Y V A + ++ Sbjct: 3 PATKSLAELQAEVCRLDDR-----------------YLLERIIGAGSYGVVIRARDTKSD 45 Query: 64 ERVVVKILKPVKK---------KKIKREVKILENLRGGTNIIKL--IDTVKDPVSKTPAL 112 R+V +K V K K+I RE+K+L + NII L I T +DP + Sbjct: 46 NRLVA--MKRVNKEIFEEVILAKRILREIKLLAHF-NDDNIIGLRNILTPEDPENFDHFY 102 Query: 113 VFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ 169 + I TD KQ+ Q LT+ I+F++Y+ L+AL HS G++HRD+ P N++++ Sbjct: 103 IVMDIMETDLKQVLRSGQELTEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVN-TN 161 Query: 170 KKLRLIDWGLAEFYHPAQEYNVR-VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 228 L++ D+GLA+ + EY V R+++ PEL+++ + Y +D+W +GC+L ++ Sbjct: 162 CDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELLG 221 Query: 229 RREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHS 288 R P F G+D +QL +I V+GT + N + ++K + H Sbjct: 222 SR-PLFQGKDRVNQLDKIVDVIGTPS------------EEDINSVGSSAAQKYLKKKSHR 268 Query: 289 ENRH------LVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 SPEALDLL +L ++ ++R+T +AM HP+ Sbjct: 269 PQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFL 311 >5AIR-A nrPDB Length = 430 Score = 136 bits (343), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 96/308 (31%), Positives = 151/308 (49%), Gaps = 29/308 (9%) Query: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK-REVKILENLR 90 P + Y + +G G + V++A + E V +K K ++ K+ K RE++I+ L Sbjct: 58 PDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFKNRELQIMRKL- 114 Query: 91 GGTNIIKL------IDTVKDPVSKTPALVFEYINNTDFK------QLYQILTDFDIRFYM 138 NI++L KD V LV +Y+ T ++ + Q L ++ YM Sbjct: 115 DHCNIVRLRYFFYSSGEKKDEVYLN--LVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 172 Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYF 198 Y+L ++L Y HS GI HRD+KP N+++D L+L D+G A+ + + SRY+ Sbjct: 173 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYY 232 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258 + PEL+ Y S+D+WS GC+LA ++ +P F G DQLV I KVLGT Sbjct: 233 RAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPT---- 287 Query: 259 LKKYHIDLDPHFNDI-LGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317 ++ +++P++ + Q W R PEA+ L +LL Y RLT Sbjct: 288 -REQIREMNPNYTEFKFPQIKAHPWTKVF----RPRTPPEAIALCSRLLEYTPTARLTPL 342 Query: 318 EAMEHPYF 325 EA H +F Sbjct: 343 EACAHSFF 350 >1UA2-A nrPDB Length = 346 Score = 135 bits (341), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 94/302 (31%), Positives = 160/302 (52%), Gaps = 34/302 (11%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK--------REVKILENLRG 91 Y+ + LG G+++ V++A + N+ V +K +K + + K RE+K+L+ L Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-S 70 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKALDY 147 NII L+D +LVF+++ TD + + + +LT I+ YM L+ L+Y Sbjct: 71 HPNIIGLLDAFGH--KSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLVD 206 H I+HRD+KP+N+++D + L+L D+GLA+ F P + Y +V +R+++ PELL Sbjct: 128 LHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 +MY +DMW++GC+LA ++ R PF G + DQL RI + LGT Sbjct: 187 ARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPT------------ 233 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLD---KLLRYDHQQRLTAKEAMEHP 323 + + D+ +++F H+ S DLLD L ++ R+TA +A++ Sbjct: 234 EEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMK 293 Query: 324 YF 325 YF Sbjct: 294 YF 295 >2F9G-A nrPDB Length = 353 Score = 135 bits (339), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 94/317 (29%), Positives = 161/317 (50%), Gaps = 49/317 (15%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGGTN 94 D+QL LG G Y V A + E V +K ++P K + RE+KIL++ + N Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH-EN 70 Query: 95 IIKLIDTVKDPVSK---TPALVFEYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCH 149 II + + ++ P S + + + TD ++ Q+L+D I++++Y+ L+A+ H Sbjct: 71 IITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR-----------VASRYF 198 ++HRD+KP N++I+ L++ D+GLA + N VA+R++ Sbjct: 130 GSNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258 + PE+++ Y ++D+WS GC+LA + RR P F G+D QL+ I ++GT Sbjct: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRR-PIFPGRDYRHQLLLIFGIIGT------ 241 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRH----------LVSPEALDLLDKLLRY 308 PH ++ L R +I S + V+P+ +DLL ++L + Sbjct: 242 ---------PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 Query: 309 DHQQRLTAKEAMEHPYF 325 D +R+TAKEA+EHPY Sbjct: 293 DPAKRITAKEALEHPYL 309 >6GU6-A nrPDB Length = 302 Score = 134 bits (336), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 89/305 (29%), Positives = 161/305 (52%), Gaps = 30/305 (9%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVKILEN 88 G+ +DY + K+G G Y V++ + T + V +K ++ V I RE+ +L+ Sbjct: 4 GSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAI-REISLLKE 62 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY------QILTDFDIRFYMYELL 142 LR NI+ L D + L+FE+++ D K+ Q + ++ Y+Y++L Sbjct: 63 LRH-PNIVSLQDVLMQ--DSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQIL 118 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGP 201 + + +CHS+ ++HRD+KP N++ID + ++L D+GLA F P + Y V + +++ P Sbjct: 119 QGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 177 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 E+L+ Y +D+WS+G + A + ++ P FHG DQL RI + LGT Sbjct: 178 EVLLGSARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTP-------- 228 Query: 262 YHIDLDPHFNDILG-QHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 320 + ++ P + +++ +W+ + + + LDLL K+L YD +R++ K A+ Sbjct: 229 -NNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMAL 287 Query: 321 EHPYF 325 HPYF Sbjct: 288 NHPYF 292 >5NGU-A nrPDB Length = 381 Score = 133 bits (335), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 95/318 (29%), Positives = 167/318 (52%), Gaps = 35/318 (11%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGGTNI 95 Y + +G G Y V A + N RV +K + P + + + RE+KIL R NI Sbjct: 44 YTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRH-ENI 102 Query: 96 IKLIDTVKDPVSKTPALVF--EYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCHSK 151 I + D ++ P + V+ + + TD +L Q L++ I +++Y++L+ L Y HS Sbjct: 103 IGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSA 162 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN----VRVASRYFKGPELLVDY 207 ++HRD+KP N++++ L++ D+GLA P ++ VA+R+++ PE++++ Sbjct: 163 NVLHRDLKPSNLLLN-TTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNS 221 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT---EELYGYL----K 260 + Y S+D+WS+GC+LA M+ R P F G+ DQL I +LG+ E+L + + Sbjct: 222 KGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKAR 280 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 320 Y + L PH N + W + + +ALDLLDK+L ++ +R+ ++A+ Sbjct: 281 NYLLSL-PHKNKV-------PWNRLFPNADS-----KALDLLDKMLTFNPHKRIEVEQAL 327 Query: 321 EHPYFYPVVKEQSQPCAD 338 HPY +P A+ Sbjct: 328 AHPYLEQYYDPSDEPIAE 345 >4QTB-A nrPDB Length = 380 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 91/320 (28%), Positives = 162/320 (50%), Gaps = 39/320 (12%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGGTNI 95 Y ++ +G G Y V A + RV +K + P + + + RE++IL R N+ Sbjct: 43 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-ENV 101 Query: 96 IKLIDTVKDPVSKTPAL----VFEYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCH 149 I + D ++ S A+ + + + TD +L Q L++ I +++Y++L+ L Y H Sbjct: 102 IGIRDILR--ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 159 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV----RVASRYFKGPELLV 205 S ++HRD+KP N++I+ L++ D+GLA P ++ VA+R+++ PE+++ Sbjct: 160 SANVLHRDLKPSNLLIN-TTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 218 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 + + Y S+D+WS+GC+LA M+ R P F G+ DQL I +LG+ D Sbjct: 219 NSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPS--------QED 269 Query: 266 LDPHFN-------DILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE 318 L+ N L ++ W + +ALDLLD++L ++ +R+T +E Sbjct: 270 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDS-----KALDLLDRMLTFNPNKRITVEE 324 Query: 319 AMEHPYFYPVVKEQSQPCAD 338 A+ HPY +P A+ Sbjct: 325 ALAHPYLEQYYDPTDEPVAE 344 >5G6V-A nrPDB Length = 324 Score = 128 bits (321), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 90/300 (30%), Positives = 164/300 (54%), Gaps = 28/300 (9%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK----REVKILENLRGGT 93 + Y + KLG G Y+ V++ + + V +K ++ ++ REV +L++L+ Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA- 60 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY----QILTDFDIRFYMYELLKALDYCH 149 NI+ L D + K+ LVFEY++ D KQ I+ +++ ++++LL+ L YCH Sbjct: 61 NIVTLHDIIH--TEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 117 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELLVDYQ 208 + ++HRD+KP N++I+ ++ +L+L D+GLA P + Y+ V + +++ P++L+ Sbjct: 118 RQKVLHRDLKPQNLLIN-ERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGST 176 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG--TEELY-GYLKKYHID 265 Y +DMW +GC+ M R P F G +QL I ++LG TEE + G L Sbjct: 177 DYSTQIDMWGVGCIFYEMATGR-PLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFK 235 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 +N + + R E + R + + DLL KLL+++ + R++A++AM+HP+F Sbjct: 236 T---YN-----YPKYRAEALLSHAPR--LDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >6DTL-A nrPDB Length = 364 Score = 128 bits (321), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 81/299 (27%), Positives = 156/299 (52%), Gaps = 32/299 (10%) Query: 43 VRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREVKILENLRGGTNIIK 97 + +G+G Y V A+N NE V +K + + K+ RE+K+L ++ NI+ Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVA 93 Query: 98 LIDTVKDPVSKTPALVFEY--INNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKG 152 + D + P+ V+ + +TD Q+ Q L++ ++++Y++L+ L Y HS Sbjct: 94 IRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 153 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDY 212 ++HRD+KP N++++ L++ D+GLA + V +R+++ PELL++ Y Sbjct: 154 VLHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTA 212 Query: 213 SLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL------KKYHIDL 266 ++D+WS+GC+ ++ R+P F G+D+ QL + +++GT K+Y L Sbjct: 213 AIDVWSVGCIFMELM-DRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQL 271 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 P+ + ++ V P A+DL++K+L +D ++R+T +A+ HPY Sbjct: 272 PPYPRQSI-------------TDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYL 317 >4IC8-A nrPDB Length = 442 Score = 127 bits (319), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 97/349 (27%), Positives = 175/349 (50%), Gaps = 44/349 (12%) Query: 2 PGPAAGSRARVYAEVNS-----LRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFE 56 PGP A A V + L++R + D ++ D+Y+++ +G G Y V Sbjct: 20 PGPVKAEPAHTAASVAAKNLALLKARSF-DV-----TFDVGDEYEIIETIGNGAYGVVSS 73 Query: 57 AINITNNERVVVKILKP-----VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVS---- 107 A ++V +K + K+ RE+KIL++ + NII + D ++ V Sbjct: 74 ARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKH-DNIIAIKDILRPTVPYGEF 132 Query: 108 KTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVM 164 K+ +V + + +D Q+ Q LT +R+++Y+LL+ L Y HS ++HRD+KP N++ Sbjct: 133 KSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLL 191 Query: 165 IDHQQKKLRLIDWGLAE--FYHPAQ------EYNVRVASRYFKGPELLVDYQMYDYSLDM 216 ++ + +L++ D+G+A PA+ EY VA+R+++ PEL++ Y ++D+ Sbjct: 192 VN-ENCELKIGDFGMARGLCTSPAEHQYFMTEY---VATRWYRAPELMLSLHEYTQAIDL 247 Query: 217 WSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQ 276 WS+GC+ M+ RR+ F G++ QL I VLGT ++ + + L Sbjct: 248 WSVGCIFGEMLARRQ-LFPGKNYVHQLQLIMMVLGTPS-PAVIQAVGAERVRAYIQSLPP 305 Query: 277 HSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 WE +R +AL LL ++LR++ R++A A+ HP+ Sbjct: 306 RQPVPWETVYPGADR-----QALSLLGRMLRFEPSARISAAAALRHPFL 349 >3GC0-A nrPDB Length = 329 Score = 126 bits (317), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 89/309 (28%), Positives = 157/309 (50%), Gaps = 27/309 (8%) Query: 31 VPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVK 84 PS + D Y+ + KLG G Y EV++AI+ NE V +K ++ V I REV Sbjct: 27 APSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAI-REVS 85 Query: 85 ILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRF---YMYEL 141 +L+ L+ NII+L + + L+FEY N D K+ D +R ++Y+L Sbjct: 86 LLKELQH-RNIIELKSVIHH--NHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQL 141 Query: 142 LKALDYCHSKGIMHRDVKPHNVMID----HQQKKLRLIDWGLAE-FYHPAQEYNVRVASR 196 + +++CHS+ +HRD+KP N+++ + L++ D+GLA F P +++ + + Sbjct: 142 INGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITL 201 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY 256 +++ PE+L+ + Y S+D+WS+ C+ A M+ + P F G DQL +I +VLG + Sbjct: 202 WYRPPEILLGSRHYSTSVDIWSIACIWAEMLM-KTPLFPGDSEIDQLFKIFEVLGLPDDT 260 Query: 257 GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA 316 + + P + + K + + + +L+ D +R++A Sbjct: 261 TWPG---VTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLE----MDPVKRISA 313 Query: 317 KEAMEHPYF 325 K A+EHPYF Sbjct: 314 KNALEHPYF 322 >5EFQ-A nrPDB Length = 347 Score = 125 bits (314), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 91/324 (28%), Positives = 165/324 (50%), Gaps = 34/324 (10%) Query: 34 WGNQ--DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKIL 86 WG + D + ++ +G G Y +V++A + E V +K ++ +K+ RE+KIL Sbjct: 5 WGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKIL 64 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPA--------LVFEYINNTDFKQLYQILTDFD---IR 135 L +II + + V D LVFEY+++ L L F+ I+ Sbjct: 65 RQLTH-QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIK 123 Query: 136 FYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP--AQEYNVRV 193 +M +L++ LDYCH K +HRD+K N+++++ + +++L D+GLA Y ++ Y +V Sbjct: 124 SFMRQLMEGLDYCHKKNFLHRDIKCSNILLNN-RGQIKLADFGLARLYSSEESRPYTNKV 182 Query: 194 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTE 253 + +++ PELL+ + Y ++D+WS GC+L + F ++P F QL I+++ G+ Sbjct: 183 ITLWYRPPELLLGEERYTPAIDVWSCGCILGEL-FTKKPIFQANQELAQLELISRICGSP 241 Query: 254 ELYGYLKKYHIDLDPHFNDI--LGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQ 311 + + P+FN + Q+ RK E F+ + ALDL D +L D Sbjct: 242 CPAVWPDVIKL---PYFNTMKPKKQYRRKLREEFV------FIPAAALDLFDYMLALDPS 292 Query: 312 QRLTAKEAMEHPYFYPVVKEQSQP 335 +R TA++A++ + V + P Sbjct: 293 KRCTAEQALQCEFLRDVEPSKMPP 316 >4ZSG-A nrPDB Length = 347 Score = 124 bits (311), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 88/308 (28%), Positives = 160/308 (51%), Gaps = 33/308 (10%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-----PVKKKKIKREVKILENLRGG 92 D+Y+++ +G G Y V A ++V +K + K+ RE+KIL++ + Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 66 Query: 93 TNIIKLIDTVKDPVS----KTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKAL 145 NII + D ++ V K+ +V + + +D Q+ Q LT +R+++Y+LL+ L Sbjct: 67 -NIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGL 124 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE--FYHPAQ------EYNVRVASRY 197 Y HS ++HRD+KP N++++ + +L++ D+G+A PA+ EY VA+R+ Sbjct: 125 KYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEY---VATRW 180 Query: 198 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 ++ PEL++ Y ++D+WS+GC+ M+ RR+ F G++ QL I VLGT Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQ-LFPGKNYVHQLQLIMMVLGTPS-PA 238 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317 ++ + + L WE +R +AL LL ++LR++ R++A Sbjct: 239 VIQAVGAERVRAYIQSLPPRQPVPWETVYPGADR-----QALSLLGRMLRFEPSARISAA 293 Query: 318 EAMEHPYF 325 A+ HP+ Sbjct: 294 AALRHPFL 301 >1G3N-A nrPDB Length = 326 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 89/305 (29%), Positives = 151/305 (49%), Gaps = 36/305 (11%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--------KIKREVKILENLRG 91 Y+ V ++G G Y +VF+A ++ N R V LK V+ + REV +L +L Sbjct: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVA--LKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 92 --GTNIIKLIDTVKDPVSKTP-----ALVFEYINNTDFKQLYQI----LTDFDIRFYMYE 140 N+++L D VS+T LVFE+++ L ++ + I+ M++ Sbjct: 71 FEHPNVVRLFDVCT--VSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 LL+ LD+ HS ++HRD+KP N+++ +++L D+GLA Y V + +++ Sbjct: 129 LLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK 260 PE+L+ Y +D+WS+GC+ A M FRR+P F G + DQL +I V+G + + Sbjct: 188 PEVLLQSS-YATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 320 + S + E F+ + DLL K L ++ +R++A A+ Sbjct: 246 DVALP-----RQAFHSKSAQPIEKFVTD-----IDELGKDLLLKCLTFNPAKRISAYSAL 295 Query: 321 EHPYF 325 HPYF Sbjct: 296 SHPYF 300 >3E3P-A nrPDB Length = 360 Score = 122 bits (305), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 88/306 (28%), Positives = 157/306 (51%), Gaps = 28/306 (9%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK-REVKILENLR--GGTN 94 D +Q+ R G+G + V + + + V I K ++ + + RE++I+++L N Sbjct: 23 DRFQVERMAGQGTFGTV--QLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPN 80 Query: 95 IIKLIDTV-----KDPVSKTPALVFEYINNT------DFKQLYQILTDFDIRFYMYELLK 143 I++L +D +V EY+ +T ++ + I+ ++++L++ Sbjct: 81 IVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIR 140 Query: 144 ALDYCH--SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 ++ H S + HRD+KPHNV+++ L+L D+G A+ P++ + SRY++ P Sbjct: 141 SIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYRAP 200 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG--TEELYGYL 259 EL+ Q Y ++D+WS+GC+ A M+ EP F G ++ QL I +VLG + E+ L Sbjct: 201 ELIFGNQHYTTAVDIWSVGCIFAEMML-GEPIFRGDNSAGQLHEIVRVLGCPSREVLRKL 259 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 H D+D L W N + S++ + EA DLL LL+Y ++R+ EA Sbjct: 260 NPSHTDVD------LYNSKGIPWSN-VFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEA 312 Query: 320 MEHPYF 325 + HPYF Sbjct: 313 LCHPYF 318 >4AGU-A nrPDB Length = 311 Score = 121 bits (304), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 88/304 (28%), Positives = 150/304 (49%), Gaps = 34/304 (11%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREVKILENLRGG 92 + Y+ + K+G G Y VF+ N + V +K PV KK RE+++L+ L+ Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH- 61 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL--YQ-ILTDFDIRFYMYELLKALDYCH 149 N++ L++ + + LVFEY ++T +L YQ + + ++ ++ L+A+++CH Sbjct: 62 PNLVNLLEVFRR--KRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCH 119 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELLVDYQ 208 +HRDVKP N++I + ++L D+G A P+ Y+ VA+R+++ PELLV Sbjct: 120 KHNCIHRDVKPENILIT-KHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDT 178 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 Y +D+W++GC+ A ++ P + G+ + DQL I K LG DL P Sbjct: 179 QYGPPVDVWAIGCVFAELL-SGVPLWPGKSDVDQLYLIRKTLG-------------DLIP 224 Query: 269 HFNDILGQHSRKRWENFIHSENRHL-------VSPEALDLLDKLLRYDHQQRLTAKEAME 321 + + E+ +S AL LL L D +RLT ++ + Sbjct: 225 RHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLH 284 Query: 322 HPYF 325 HPYF Sbjct: 285 HPYF 288 >4NST-A nrPDB Length = 351 Score = 121 bits (303), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 88/323 (27%), Positives = 165/323 (51%), Gaps = 32/323 (9%) Query: 34 WGNQ--DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKIL 86 WG + D + ++ +G G Y +V++A + E V +K ++ +K+ RE+KIL Sbjct: 7 WGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKIL 66 Query: 87 ENL--RGGTNIIKLIDTVKDPV-----SKTPALVFEYINNTDFKQLYQILTDFD---IRF 136 L R N+ +++ +D + LVFEY+++ L L F I+ Sbjct: 67 RQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKS 126 Query: 137 YMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP--AQEYNVRVA 194 +M +L++ L+YCH K +HRD+K N+++++ +++L D+GLA Y+ ++ Y +V Sbjct: 127 FMKQLMEGLEYCHKKNFLHRDIKCSNILLNN-SGQIKLADFGLARLYNSEESRPYTNKVI 185 Query: 195 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE 254 + +++ PELL+ + Y ++D+WS GC+L + F ++P F QL I+++ G+ Sbjct: 186 TLWYRPPELLLGEERYTPAIDVWSCGCILGEL-FTKKPIFQANLELAQLELISRLCGSPC 244 Query: 255 LYGYLKKYHIDLDPHFNDI--LGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQ 312 + + P+FN + Q+ R+ E F + ALDLLD +L D + Sbjct: 245 PAVWPDVIKL---PYFNTMKPKKQYRRRLREEF------SFIPSAALDLLDHMLTLDPSK 295 Query: 313 RLTAKEAMEHPYFYPVVKEQSQP 335 R TA++ ++ + V + P Sbjct: 296 RCTAEQTLQSDFLKDVELSKMAP 318 >4BGQ-A nrPDB Length = 304 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 92/311 (29%), Positives = 157/311 (50%), Gaps = 32/311 (10%) Query: 31 VPSWGN-QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----KKKIKREVK 84 +P+ GN + ++++ +G G Y V + + +E V +K K + K+ RE+K Sbjct: 4 IPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELK 63 Query: 85 ILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDF---DIRFYMYEL 141 +L L+ NI++L + + LVFEY+ + L ++ ++ Y+Y+L Sbjct: 64 MLRTLKQ-ENIVELKEAFRR--RGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQL 120 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ--EYNVRVASRYFK 199 +KA+ +CH I+HRD+KP N++I H L+L D+G A Y+ VA+R+++ Sbjct: 121 IKAIHWCHKNDIVHRDIKPENLLISHND-VLKLCDFGFARNLSEGNNANYDEEVATRWYR 179 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG---TEELY 256 PELL+ Y S+DMWS+GC+L + +P F G+ DQL I KVLG +E++ Sbjct: 180 SPELLLGAP-YGKSVDMWSVGCILGEL-SDGQPLFPGESEIDQLFTIQKVLGPLPSEQMK 237 Query: 257 GYLK--KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL 314 + ++H P N Q +R+ ++S LDL+ LL+ D R Sbjct: 238 LFYSNPRFHGLRFPAVNH--PQSLERRYLGILNS--------VLLDLMKNLLKLDPADRY 287 Query: 315 TAKEAMEHPYF 325 ++ + HP F Sbjct: 288 LTEQCLNHPTF 298 >3MIA-A nrPDB Length = 351 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 98/329 (29%), Positives = 169/329 (51%), Gaps = 33/329 (10%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVK-ILKPVKKKKIK----REVKILENLR--GG 92 Y+ + K+G+G + EVF+A + ++V +K +L +K+ RE+KIL+ L+ Sbjct: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Query: 93 TNIIKLIDTVKDPVSKTPA---LVFEYINNTDFKQLYQILTDF---DIRFYMYELLKALD 146 N+I++ T P ++ LVF++ + L +L F +I+ M LL L Sbjct: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-----YNVRVASRYFKGP 201 Y H I+HRD+K NV+I + L+L D+GLA + A+ Y RV + +++ P Sbjct: 139 YIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG--TEELYGYL 259 ELL+ + Y +D+W GC++A M + R P G QL I+++ G T E++ + Sbjct: 198 ELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGSITPEVWPNV 256 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 Y +L + GQ +++ ++ + + R P ALDL+DKLL D QR+ + +A Sbjct: 257 DNY--ELYEKLELVKGQ--KRKVKDRLKAYVR---DPYALDLIDKLLVLDPAQRIDSDDA 309 Query: 320 MEHPYFYPVVKEQSQPCADNAVLSSGLTA 348 + H +F+ P +LS+ LT+ Sbjct: 310 LNHDFFW----SDPMPSDLKGMLSTHLTS 334 >4BBM-A nrPDB Length = 331 Score = 118 bits (295), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 88/305 (28%), Positives = 152/305 (49%), Gaps = 32/305 (10%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVK-ILKPVKKKKIK----REVKILENLR 90 + + Y+ + +G G Y V + N V +K L+ K +K RE+K+L+ LR Sbjct: 23 SMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR 82 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYELLKALDY 147 N++ L++ K K LVFE++++T L D ++ Y+++++ + + Sbjct: 83 H-ENLVNLLEVCKK--KKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGF 139 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLVD 206 CHS I+HRD+KP N+++ Q ++L D+G A P + Y+ VA+R+++ PELLV Sbjct: 140 CHSHNIIHRDIKPENILVS-QSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVG 198 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT-----EELYGYLKK 261 Y ++D+W++GC++ M F EP F G + DQL I LG +EL+ Sbjct: 199 DVKYGKAVDVWAIGCLVTEM-FMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELF----- 252 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRH-LVSPEALDLLDKLLRYDHQQRLTAKEAM 320 + +P F + ++R E R+ +S +DL K L D +R E + Sbjct: 253 ---NKNPVFAGVRLPEIKEREP----LERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELL 305 Query: 321 EHPYF 325 H +F Sbjct: 306 HHDFF 310 >3PG1-A nrPDB Length = 362 Score = 115 bits (288), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 79/309 (25%), Positives = 147/309 (47%), Gaps = 29/309 (9%) Query: 37 QDDYQLVRKLGRGKYSEVFEAI-------------NITNNERVVVKILKPVKKKKIKREV 83 Q Y + R + G Y V + N ++ R V + K++ RE+ Sbjct: 21 QSPYTVQRFISSGSYGAVCAGVDSEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREI 80 Query: 84 KILENLRGGTNIIKLIDTV---KDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRF 136 ++L + NI+ L D ++P LV E + TD Q+ +++ I++ Sbjct: 81 RLLNHFHH-PNILGLRDIFVHFEEPAMHKLYLVTELMR-TDLAQVIHDQRIVISPQHIQY 138 Query: 137 YMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASR 196 +MY +L L H G++HRD+ P N+++ + + D+ LA V R Sbjct: 139 FMYHILLGLHVLHEAGVVHRDLHPGNILLA-DNNDITICDFNLAREDTADANKTHYVTHR 197 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY 256 +++ PEL++ ++ + +DMWS GC++A M F R+ F G Y+QL +I +V+GT ++ Sbjct: 198 WYRAPELVMQFKGFTKLVDMWSAGCVMAEM-FNRKALFRGSTFYNQLNKIVEVVGTPKIE 256 Query: 257 GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA 316 + + + L + W + + + P ALDL+ K+L ++ Q+R++ Sbjct: 257 DVVMFSSPSARDYLRNSLSNVPARAWTAVVPTAD-----PVALDLIAKMLEFNPQRRIST 311 Query: 317 KEAMEHPYF 325 ++A+ HPYF Sbjct: 312 EQALRHPYF 320 >3NIE-A nrPDB Length = 429 Score = 112 bits (279), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 95/361 (26%), Positives = 166/361 (45%), Gaps = 77/361 (21%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP-----VKKKKIKREVKILENLRGG 92 D+Y++ +GRG Y V+ A + N+ V +K + + K+I RE+ IL L+ Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 93 TNIIKLIDTV--KDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDY 147 II+L D + +D + + I ++D K+L++ LT+ ++ +Y LL + Sbjct: 88 Y-IIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIFLTEQHVKTILYNLLLGEKF 146 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV---------------- 191 H GI+HRD+KP N +++ Q +++ D+GLA + ++ ++ Sbjct: 147 IHESGIIHRDLKPANCLLN-QDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPH 205 Query: 192 ----------RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI----------FRRE 231 V +R+++ PEL++ + Y S+D+WS GC+ A ++ R Sbjct: 206 NKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRF 265 Query: 232 PFF-----------------HGQDNYDQLVRIAKVLGT---EELYGYLKKYHIDLDPHFN 271 P F H + N DQL I V+GT E+L K+ I F Sbjct: 266 PLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFP 325 Query: 272 DILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKE 331 G K++ + +S E +DLL+ +LR++ Q+R+T +A+ HPY V KE Sbjct: 326 TRDGIDLSKKYSS---------ISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKE 376 Query: 332 Q 332 Sbjct: 377 N 377 >3ZDU-A nrPDB Length = 325 Score = 111 bits (277), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 81/301 (26%), Positives = 144/301 (47%), Gaps = 33/301 (10%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKIL--KPVKK--KKIKREVKILENLRGGTNI 95 Y+ + K+G G Y V + + + V +KI +P + K RE+K L+ N+ Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHH-ENL 63 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYELLKALDYCHSKG 152 + LI+ + K LVFE+I++T +L + +R Y++++L+A+DY HS Sbjct: 64 VNLIEVFRQ--KKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN 121 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLVDYQMYD 211 I+HRD+KP N+++ Q +L D+G A P Y+ VA+R+++ PEL++ Y Sbjct: 122 IIHRDIKPENILVS-QSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYG 180 Query: 212 YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFN 271 +D+W+LGCM+ M P+ + D L +I +G +L PH Sbjct: 181 KPVDIWALGCMIIEMA-TGNPYLPSSSDLDLLHKIVLKVG-------------NLSPHLQ 226 Query: 272 DILGQH---SRKRWENFIHSENRHLVSPE----ALDLLDKLLRYDHQQRLTAKEAMEHPY 324 +I + + H +N P+ D++ L+ D R+++ + + H Y Sbjct: 227 NIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEY 286 Query: 325 F 325 F Sbjct: 287 F 287 >4O2Z-A nrPDB Length = 377 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 87/323 (26%), Positives = 155/323 (47%), Gaps = 48/323 (14%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-----KKIKREVKIL-----ENL 89 Y L++ LG G Y ++ E+V +K + V + K++ RE+ ++ ENL Sbjct: 47 YTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENL 106 Query: 90 RGGTNIIKLID----TVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKAL 145 NI+ + + +D TP + + N + Q+L + +++++Y++L+ L Sbjct: 107 LNVVNILPPLKREYHSFEDVYVVTPLMDVDM--NVVLRS-RQVLEESHMQYFVYQILRGL 163 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELL 204 Y HS + HRD+KP N ++ + +L++ID+GL+ P E V +R+++ PELL Sbjct: 164 KYLHSANVAHRDLKPAN-LVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELL 222 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 ++ Y ++D+WS+GC+ A M + R+P F G++ DQL IA+ HI Sbjct: 223 LENTNYSTAVDIWSVGCIFAEM-YNRKPVFPGRNTMDQLRMIAQ--------------HI 267 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSP----------EALDLLDKLLRYDHQQRL 314 P + +H R+ E + L P E +D L K+ D +R Sbjct: 268 GKPPAS---IVEH-REALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRP 323 Query: 315 TAKEAMEHPYFYPVVKEQSQPCA 337 TA + + HPY + E+ +P Sbjct: 324 TAADMLAHPYLAHLHDEEDEPTC 346 >2I6L-A nrPDB Length = 320 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 87/312 (27%), Positives = 147/312 (47%), Gaps = 41/312 (13%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVK---ILKPVKKKKIKREVKILENLRGGTNII 96 Y ++ LG G VF A++ ++RV +K + P K RE+KI+ L NI+ Sbjct: 13 YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRL-DHDNIV 71 Query: 97 KLIDTV-------KDPVSKTPALVFEYI----NNTDFKQLYQ--ILTDFDIRFYMYELLK 143 K+ + + D V L YI TD + + L + R +MY+LL+ Sbjct: 72 KVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLR 131 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVA----SRYFK 199 L Y HS ++HRD+KP N+ I+ + L++ D+GLA P + ++ +++++ Sbjct: 132 GLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYR 191 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT------E 253 P LL+ Y ++DMW+ GC+ A M+ + F G +Q+ I + + + Sbjct: 192 SPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKT-LFAGAHELEQMQLILESIPVVHEEDRQ 250 Query: 254 ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR 313 EL + Y ND+ H K + +S EA+D L+++L + R Sbjct: 251 ELLSVIPVY------IRNDMTEPH--KPLTQLLPG-----ISREAVDFLEQILTFSPMDR 297 Query: 314 LTAKEAMEHPYF 325 LTA+EA+ HPY Sbjct: 298 LTAEEALSHPYM 309 >3RP9-A nrPDB Length = 458 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 99/365 (27%), Positives = 162/365 (44%), Gaps = 80/365 (21%) Query: 34 WGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVK-ILKP----VKKKKIKREVKILEN 88 W D Y++ +G G Y V EA + V +K IL+ + K+I RE+ IL Sbjct: 49 WQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNR 108 Query: 89 LRGGTNIIKLIDTV--KDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLK 143 L +++K++D V KD V I ++DFK+L++ LT+ I+ +Y LL Sbjct: 109 L-NHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLLV 167 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE---------------------- 181 + Y HS GI+HRD+KP N +++ Q +++ D+GLA Sbjct: 168 GVKYVHSAGILHRDLKPANCLVN-QDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMN 226 Query: 182 ---FYHPA---QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-------- 227 F H ++ V +R+++ PEL++ + Y ++D+WS+GC+ A ++ Sbjct: 227 LVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVA 286 Query: 228 --FRREPF--------------------FHGQDNYDQLVRIAKVLGT--EELYGYLKKYH 263 R P FH + N DQL I +LGT EE L+K Sbjct: 287 YHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKE- 345 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 D + + E F S S +A+ LL ++L ++ +R+T E + HP Sbjct: 346 -DAKRYIRIFPKREGTDLAERFPAS------SADAIHLLKRMLVFNPNKRITINECLAHP 398 Query: 324 YFYPV 328 +F V Sbjct: 399 FFKEV 403 >3N9X-A nrPDB Length = 432 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 95/370 (25%), Positives = 174/370 (47%), Gaps = 85/370 (22%) Query: 29 AHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP-----VKKKKIKREV 83 HVP D+Y + +GRG Y V+ A + + V +K + + K+I RE+ Sbjct: 22 VHVP-----DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREI 76 Query: 84 KILENLRGGTNIIKLID-TVKDPVSKTPAL-VFEYINNTDFKQLYQ---ILTDFDIRFYM 138 IL L+ II+L D + D + K L + I ++D K+L++ LT+ I+ + Sbjct: 77 TILNRLKSDY-IIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIFLTEEHIKTIL 135 Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV------- 191 Y LL ++ H GI+HRD+KP N +++ Q +++ D+GLA + ++ N+ Sbjct: 136 YNLLLGENFIHESGIIHRDLKPANCLLN-QDCSVKVCDFGLARTINSEKDTNIVNDLEEN 194 Query: 192 ----------------RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-------- 227 V +R+++ PEL++ + Y S+D+WS GC+ A ++ Sbjct: 195 EEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHIN 254 Query: 228 --FRREPFF-----------------HGQDNYDQLVRIAKVLG--TEELYGYLKK----Y 262 R P F H + N DQL I ++G TE+ + K Sbjct: 255 DPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIK 314 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 +I L PH I + ++++ + +S + ++LL+ +L+++ +R+T +A++H Sbjct: 315 YIKLFPHRKPI---NLKQKYPS---------ISDDGINLLESMLKFNPNKRITIDQALDH 362 Query: 323 PYFYPVVKEQ 332 PY V K++ Sbjct: 363 PYLKDVRKKK 372 >3E7O-A nrPDB Length = 360 Score = 104 bits (259), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 149/300 (49%), Gaps = 18/300 (6%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKIL-KPVKK----KKIKREVKILENLRGGTN 94 YQ ++ +G G V A + V VK L +P + K+ RE+ +L+ + N Sbjct: 24 YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCV-NHKN 82 Query: 95 IIKLIDTVKDPVS----KTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHS 150 II L++ + + LV E ++ + ++ L + + +Y++L + + HS Sbjct: 83 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHS 142 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 GI+HRD+KP N+++ L+++D+GLA V +RY++ PE+++ Y Sbjct: 143 AGIIHRDLKPSNIVV-KSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVILGMG-Y 200 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT--EELYGYLK---KYHID 265 ++D+WS+GC++ ++ + F G D+ DQ ++ + LGT E L+ + +++ Sbjct: 201 KENVDIWSVGCIMGELV-KGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRNYVE 259 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 P + I + W SE + + +A DLL K+L D +R++ EA+ HPY Sbjct: 260 NRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI 319 >5JN2-A nrPDB Length = 525 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 88/325 (27%), Positives = 153/325 (47%), Gaps = 63/325 (19%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL--KPVKKKKIK----REVKILENLRG 91 D Y+ R LG+G + EV + + VK++ + VK+K K REV++L+ L Sbjct: 67 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 126 Query: 92 GTNIIKLIDTVKDP--------VSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLK 143 NI+KL + +D V L E I+ F ++ D + ++L Sbjct: 127 -PNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEV-------DAARIIRQVLS 178 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 + Y H I+HRD+KP N++++ + K +R+ID+GL+ + +++ ++ + Y+ P Sbjct: 179 GITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAP 238 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 E+L + YD D+WS G +L ++ P F+G + YD L ++ K K Sbjct: 239 EVL--HGTYDEKCDVWSTGVILY-ILLSGCPPFNGANEYDILKKVEK-----------GK 284 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 Y +L +W+ VS A DL+ K+L Y R++A++A++ Sbjct: 285 YTFEL-------------PQWKK---------VSESAKDLIRKMLTYVPSMRISARDALD 322 Query: 322 HPYFYPVVKEQSQ---PCADNAVLS 343 H + KEQ P DNA+L+ Sbjct: 323 HEWIQTYTKEQISVDVPSLDNAILN 347 >5ZTN-A nrPDB Length = 429 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 82/326 (25%), Positives = 163/326 (50%), Gaps = 52/326 (15%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILENLR-----GG 92 Y++++ +G+G + +V +A + ++ V +K+++ K+ ++ E++ILE+LR Sbjct: 99 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT 158 Query: 93 TNIIKLID--TVKDPVSKTPALV----FEYINNTDFKQLYQILTDFDIRFYMYELLKALD 146 N+I +++ T ++ + T L+ +E I F+ L +R + + +L+ LD Sbjct: 159 MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPL----VRKFAHSILQCLD 214 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKK-LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV 205 H I+H D+KP N+++ Q + +++ID+G + + H Q + SR+++ PE+++ Sbjct: 215 ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEH--QRVYTYIQSRFYRAPEVIL 272 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG--TEELY------- 256 + Y +DMWSLGC+LA ++ P G+D DQL + ++LG +++L Sbjct: 273 GAR-YGMPIDMWSLGCILAELL-TGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAK 330 Query: 257 ------GYLKKYHIDLDPHFNDIL-GQHSR----------KRWENFIHSENRHLVSPEAL 299 GY + + + +L G SR + W N + + P L Sbjct: 331 NFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCD----DPLFL 386 Query: 300 DLLDKLLRYDHQQRLTAKEAMEHPYF 325 D L + L +D R+T +A+ HP+ Sbjct: 387 DFLKQCLEWDPAVRMTPGQALRHPWL 412 >1JNK-A nrPDB Length = 423 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 86/336 (25%), Positives = 163/336 (48%), Gaps = 30/336 (8%) Query: 10 ARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVK 69 A+ Y S +++ E ++ YQ ++ +G G V A + + V +K Sbjct: 34 AKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK 93 Query: 70 IL-KPVKK----KKIKREVKILENLRGGTNIIKLIDTVKDPVS----KTPALVFEYINNT 120 L +P + K+ RE+ +L NII L++ + + LV E ++ Sbjct: 94 KLSRPFQNQTHAKRAYREL-VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-A 151 Query: 121 DFKQLYQILTDFD-IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL 179 + Q+ Q+ D + + + +Y++L + + HS GI+HRD+KP N+++ L+++D+GL Sbjct: 152 NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-KSDCTLKILDFGL 210 Query: 180 AEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDN 239 A + V +RY++ PE+++ Y ++D+WS+GC++ M+ R + F G+D Sbjct: 211 ARTAGTSFMMTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMV-RHKILFPGRDY 268 Query: 240 YDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENF----------IHSE 289 DQ ++ + LGT ++KK L P + + + F SE Sbjct: 269 IDQWNKVIEQLGT-PCPEFMKK----LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSE 323 Query: 290 NRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 + L + +A DLL K+L D +R++ +A++HPY Sbjct: 324 HNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 >2XS0-A nrPDB Length = 386 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 85/324 (26%), Positives = 160/324 (49%), Gaps = 22/324 (6%) Query: 18 SLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-KPVKK 76 S R ++ E ++ YQ ++ +G G V A + V +K L +P + Sbjct: 6 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 65 Query: 77 ----KKIKREVKILENLRGGTNIIKLIDTVKDPVS----KTPALVFEYINNTDFKQLYQI 128 K+ RE+ +L NII L++ S + +V E ++ + Q+ Q+ Sbjct: 66 QTHAKRAYREL-VLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMD-ANLCQVIQM 123 Query: 129 LTDFD-IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ 187 D + + + +Y++L + + HS GI+HRD+KP N+++ L+++D+GLA + Sbjct: 124 ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-KSDCTLKILDFGLARTAGTSF 182 Query: 188 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIA 247 V +RY++ PE+++ Y ++D+WS+GC++ MI + F G D+ DQ ++ Sbjct: 183 MMVPFVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMI-KGGVLFPGTDHIDQWNKVI 240 Query: 248 KVLGTEELYGYLKKYHIDLDPHFND---ILGQHSRKRWENFIH---SENRHLVSPEALDL 301 + LGT ++KK + + + G K + + + SE+ L + +A DL Sbjct: 241 EQLGT-PCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDL 299 Query: 302 LDKLLRYDHQQRLTAKEAMEHPYF 325 L K+L D +R++ EA++HPY Sbjct: 300 LSKMLVIDASKRISVDEALQHPYI 323 >3LIJ-A nrPDB Length = 494 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 86/317 (27%), Positives = 155/317 (48%), Gaps = 55/317 (17%) Query: 40 YQLVRKLGRGKYSEVFEAIN-ITNNERVVVKILKPVK-----KKKIKREVKILENLRGGT 93 YQ V+KLG G Y EV + +T+ ER + KI++ K+ EV +L+ L Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAI-KIIRKTSVSTSSNSKLLEEVAVLK-LLDHP 96 Query: 94 NIIKLIDTVKDPVSKTPALVFE-YINNTDFKQLYQIL--TDFDIRFYMYELLKALDYCHS 150 NI+KL D +D + LV E Y F ++ + + D + ++L + Y H Sbjct: 97 NIMKLYDFFEDK--RNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHK 154 Query: 151 KGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQ 208 I+HRD+KP N++++ ++K ++++D+GL+ + ++ R+ + Y+ PE+L + Sbjct: 155 HNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL--RK 212 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 YD D+WS+G +L ++ P F GQ + + L ++ K KY D Sbjct: 213 KYDEKCDVWSIGVILF-ILLAGYPPFGGQTDQEILRKVEK-----------GKYTFD--- 257 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPV 328 W+N VS A DL+ ++L++D Q+R++A++A+EHP+ + Sbjct: 258 ----------SPEWKN---------VSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEM 298 Query: 329 VKEQSQ----PCADNAV 341 ++ P NA+ Sbjct: 299 CSKKESGIELPSLANAI 315 >3FI2-A nrPDB Length = 353 Score = 100 bits (250), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 82/306 (26%), Positives = 153/306 (50%), Gaps = 30/306 (9%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKIL-KPVKK----KKIKREVKILENLRGGTN 94 YQ ++ +G G V A + + V +K L +P + K+ RE+ +L N Sbjct: 26 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKN 84 Query: 95 IIKLIDTVKDPVS----KTPALVFEYINNTDFKQLYQILTDFD-IRFYMYELLKALDYCH 149 II L++ + + LV E ++ + Q+ Q+ D + + + +Y++L + + H Sbjct: 85 IISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDHERMSYLLYQMLCGIKHLH 143 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 S GI+HRD+KP N+++ L+++D+GLA + V +RY++ PE+++ Sbjct: 144 SAGIIHRDLKPSNIVV-KSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG- 201 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 Y ++D+WS+GC++ M+ R + F G+D DQ ++ + LGT ++KK L P Sbjct: 202 YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGT-PCPEFMKK----LQPT 255 Query: 270 FNDILGQHSRKRWENF----------IHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 + + + F SE+ L + +A DLL K+L D +R++ +A Sbjct: 256 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 315 Query: 320 MEHPYF 325 ++HPY Sbjct: 316 LQHPYI 321 >5AWM-A nrPDB Length = 394 Score = 100 bits (249), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 82/304 (26%), Positives = 149/304 (49%), Gaps = 31/304 (10%) Query: 43 VRKLGRGKYSEVFEAINITNNERVVVKIL-KPVKK----KKIKREVKILENLRGGTNIIK 97 +R +G G V A + + V +K L +P + K+ RE K+++ L NII Sbjct: 49 LRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMK-LVNHKNIIG 107 Query: 98 LIDTVKDPVS----KTPALVFEYINNTDFKQLYQILTDFD-IRFYMYELLKALDYCHSKG 152 L++ + + LV E ++ + Q+ Q+ D D + + +Y++L + + HS G Sbjct: 108 LLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAG 166 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDY 212 I+HRD+KP N+++ L+++D+GLA V +RY++ PE+++ Y Sbjct: 167 IIHRDLKPSNIVVK-ADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG-YTE 224 Query: 213 SLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFND 272 ++D+WS+GC++ MI R F G D+ DQ +I + LGT + L P + Sbjct: 225 NVDIWSVGCIMGEMI-RGGVLFPGTDHIDQWNKIIEQLGTPS-----PSFMQRLQPTVRN 278 Query: 273 ILGQHSRKRWENF-----------IHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 + R +F +++N + +A +LL K+L D +QR++ EA++ Sbjct: 279 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 338 Query: 322 HPYF 325 H Y Sbjct: 339 HEYI 342 >2W96-B nrPDB Length = 306 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 69/228 (30%), Positives = 119/228 (52%), Gaps = 21/228 (9%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILK-PVKKKKIK----REVKILENLRG--G 92 Y+ V ++G G Y V++A + + V +K ++ P ++ + REV +L L Sbjct: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEH 65 Query: 93 TNIIKLIDTVKDPVSKTP-----ALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLK 143 N+++L+D S+T LVFE+++ L + L I+ M + L+ Sbjct: 66 PNVVRLMDVCA--TSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 123 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 LD+ H+ I+HRD+KP N+++ ++L D+GLA Y + V + +++ PE+ Sbjct: 124 GLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG 251 L+ Y +DMWS+GC+ A M FRR+P F G DQL +I ++G Sbjct: 183 LLQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIG 228 >3NCG-A nrPDB Length = 486 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 88/321 (27%), Positives = 151/321 (47%), Gaps = 50/321 (15%) Query: 40 YQLVRKLGRGKYSEVFEAIN-ITNNERVVVKILKPVKKKK----IKREVKILENLRGGTN 94 Y +V LG+G + EV + + IT E V I K K K I REV++L+ L N Sbjct: 24 YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL-DHPN 82 Query: 95 IIKLIDTVKDPVSKTPALVFE-YINNTDFKQLYQI--LTDFDIRFYMYELLKALDYCHSK 151 I+KL + ++D S + +V E Y F ++ + ++ D + ++ + Y H Sbjct: 83 IMKLFEILED--SSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 152 GIMHRDVKPHNVMIDHQQK--KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 I+HRD+KP N++++ ++K +++ID+GL+ + + R+ + Y+ PE+L Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL--RGT 198 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 YD D+WS G +L ++ P F+G++ YD L R+ KY DL Sbjct: 199 YDEKCDVWSAGVILY-ILLSGTPPFYGKNEYDILKRVET-----------GKYAFDL--- 243 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVV 329 +W +S +A DL+ K+L + R+TA + +EHP+ Sbjct: 244 ----------PQWRT---------ISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYS 284 Query: 330 KEQSQPCADNAVLSSGLTAAR 350 E + +D L S +T R Sbjct: 285 SE-TPTISDLPSLESAMTNIR 304 >5Y86-A nrPDB Length = 588 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 90/363 (24%), Positives = 172/363 (47%), Gaps = 52/363 (14%) Query: 3 GPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITN 62 GP A R V N+ + HVP Y++++ +G+G + +V + Sbjct: 172 GPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL 231 Query: 63 NERVVVKILKPVKK--KKIKREVKILENLR-----GGTNIIKLID--TVKDPVSKTPALV 113 + V +K+++ K+ ++ E++ILE+L+ G N+I +++ T ++ V L+ Sbjct: 232 RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL 291 Query: 114 ----FEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ 169 +E I F+ L +R + +L++LD H I+H D+KP N+++ H Sbjct: 292 SIDLYELIKKNKFQGFSVQL----VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHG 347 Query: 170 K-KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 228 + ++ID+G + F + Q+ + SR+++ PE+++ + Y +D+WS GC+LA ++ Sbjct: 348 RSSTKVIDFGSSCFEY--QKLYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELL- 403 Query: 229 RREPFFHGQDNYDQLVRIAKVLG--TEELYGYLK--KYHIDLD--PHFNDI--------- 273 +P F G+D DQL + ++LG +L K KY I+ P + + Sbjct: 404 TGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVV 463 Query: 274 -LGQHSR----------KRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 +G SR K W + + +L ++ L + L +D RLT +A+ H Sbjct: 464 LVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF----IEFLKRCLHWDPSARLTPAQALRH 519 Query: 323 PYF 325 P+ Sbjct: 520 PWI 522 >4F9B-A nrPDB Length = 361 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 96/352 (27%), Positives = 151/352 (42%), Gaps = 61/352 (17%) Query: 27 YEAHVPSWGNQDDYQLVRKLGRGKYSEVFEA---INITNNERVVVKILKPVKKK-KIKRE 82 YEA VP N +++ K+G G +S V+ A + + E++ +K L P +I E Sbjct: 13 YEA-VPQLSNV--FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAE 69 Query: 83 VKILENLRGGTNI--IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYE 140 ++ L G N+ +K D V + Y+ + F + L+ ++R YM Sbjct: 70 LQCLTVAGGQDNVMGVKYCFRKNDHV----VIAMPYLEHESFLDILNSLSFQEVREYMLN 125 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA-------------- 186 L KAL H GI+HRDVKP N + + + KK L+D+GLA+ H Sbjct: 126 LFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQ 185 Query: 187 ---------------QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRRE 231 Q+ R + F+ PE+L ++DMWS G + S++ R Sbjct: 186 ERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRY 245 Query: 232 PFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENF------ 285 PF+ D+ L +I + G+ E K + + ++ Q RK E Sbjct: 246 PFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCS-KEVPAQDLRKLCERLRGMDSS 304 Query: 286 ------------IHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 + E + V EA DLLDKLL + R+TA+EA+ HP+F Sbjct: 305 TPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFF 356 >3DFA-A nrPDB Length = 286 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 82/296 (27%), Positives = 142/296 (47%), Gaps = 49/296 (16%) Query: 40 YQLVRKLGRGKYSEVFEAIN-ITNNERVVVKILKPVKKKK----IKREVKILENLRGGTN 94 Y +V LG+G + EV + + IT E V I K K K I REV++L+ L N Sbjct: 24 YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL-DHPN 82 Query: 95 IIKLIDTVKDPVSKTPALVFE-YINNTDFKQLYQI--LTDFDIRFYMYELLKALDYCHSK 151 I+KL + ++D S + +V E Y F ++ + ++ D + ++ + Y H Sbjct: 83 IMKLFEILED--SSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 152 GIMHRDVKPHNVMIDHQQK--KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 I+HRD+KP N++++ ++K +++ID+GL+ + + R+ + Y+ PE+L Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL--RGT 198 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 YD D+WS G +L ++ P F+G++ YD L R+ KY DL Sbjct: 199 YDEKCDVWSAGVILY-ILLSGTPPFYGKNEYDILKRVET-----------GKYAFDL--- 243 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 +W +S +A DL+ K+L + R+TA + +EHP+ Sbjct: 244 ----------PQWRT---------ISDDAKDLIRKMLTFHPSLRITATQCLEHPWI 280 >6FDY-U nrPDB Length = 276 Score = 97.4 bits (241), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 82/307 (26%), Positives = 137/307 (44%), Gaps = 55/307 (17%) Query: 32 PSWG--NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR-------- 81 P WG D + L +LG G Y+ V++A + VV +K V KK + + Sbjct: 3 PGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVA--IKCVAKKSLNKASVENLLT 60 Query: 82 EVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD---FKQLYQILTDFDIRFYM 138 E++IL+ +R +I++L D D S L+ E+ D F +IL + R +M Sbjct: 61 EIEILKGIRH-PHIVQLKDFQWD--SDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFM 117 Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQKK-LRLIDWGLAEFYHPAQEYNVRVASRY 197 +L AL + H + I H D+KP N+++ +K L+L D+G A+ P E +V S Sbjct: 118 QQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL 177 Query: 198 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 + PE++ Q YD +D+WS+G +L +F + PF ++ +L Sbjct: 178 YMAPEMVCQRQ-YDARVDLWSMGVILYEALFGQPPF--ASRSFSEL-------------- 220 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317 + R I R L+S + DLL +LL D +R++ + Sbjct: 221 -------------------EEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQ 261 Query: 318 EAMEHPY 324 + HP+ Sbjct: 262 DFFAHPW 268 >3MA6-A nrPDB Length = 298 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 83/311 (26%), Positives = 146/311 (46%), Gaps = 60/311 (19%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL--KPVKKKKIK----REVKILENLRG 91 D Y+ R LG+G + EV + + VK++ + VK+K K REV++L+ L Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL-D 90 Query: 92 GTNIIKLIDTVKDP--------VSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLK 143 NI+KL + +D V L E I+ F ++ D + ++L Sbjct: 91 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRF-------SEVDAARIIRQVLS 143 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 + Y H I+HRD+KP N++++ + K +R+ID+GL+ + +++ ++ + Y+ P Sbjct: 144 GITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAP 203 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 E+L + YD D+WS G +L ++ P F+G + YD L ++ K K Sbjct: 204 EVL--HGTYDEKCDVWSTGVILY-ILLSGCPPFNGANEYDILKKVEK-----------GK 249 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 Y +L +W+ VS A DL+ K+L Y R++A++A++ Sbjct: 250 YTFEL-------------PQWKK---------VSESAKDLIRKMLTYVPSMRISARDALD 287 Query: 322 HPYFYPVVKEQ 332 H + KEQ Sbjct: 288 HEWIQTYTKEQ 298 >4CRL-A nrPDB Length = 406 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 81/319 (25%), Positives = 155/319 (48%), Gaps = 47/319 (14%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK----REVKILENLRGGTNIIKLID 100 K+GRG Y V++A + LK ++ I RE+ +L L+ N+I L Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYA-LKQIEGTGISMSACREIALLRELKH-PNVISLQK 86 Query: 101 TVKDPVSKTPALVFEYINNTDF------------KQLYQILTDFDIRFYMYELLKALDYC 148 + L+F+Y + + K+ Q+ ++ +Y++L + Y Sbjct: 87 VFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGM-VKSLLYQILDGIHYL 145 Query: 149 HSKGIMHRDVKPHNVMI---DHQQKKLRLIDWGLAEFYH----PAQEYNVRVASRYFKGP 201 H+ ++HRD+KP N+++ ++ ++++ D G A ++ P + + V + +++ P Sbjct: 146 HANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAP 205 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQD---------NYDQLVRIAKVLG- 251 ELL+ + Y ++D+W++GC+ A ++ EP FH + ++DQL RI V+G Sbjct: 206 ELLLGARHYTKAIDIWAIGCIFAELL-TSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 264 Query: 252 -TEELYGYLKKYHIDLDPHFNDILGQHSRKRWEN--FIHSENRHLVSPE--ALDLLDKLL 306 ++ + +KK P + ++ R + N I +H V P+ A LL KLL Sbjct: 265 PADKDWEDIKKM-----PEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLL 319 Query: 307 RYDHQQRLTAKEAMEHPYF 325 D +R+T+++AM+ PYF Sbjct: 320 TMDPIKRITSEQAMQDPYF 338 >4NIF-A nrPDB Length = 333 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 95/324 (29%), Positives = 142/324 (43%), Gaps = 51/324 (15%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIK 97 D Y + +G G YSE ++ N VK++ K+ E++IL NII Sbjct: 8 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDP-SEEIEILLRYGQHPNIIT 66 Query: 98 LIDTVKDPVSKTPALVFEYINNTDF--KQLYQ-ILTDFDIRFYMYELLKALDYCHSKGIM 154 L D D K LV E + + K L Q ++ + F ++ + K ++Y HS+G++ Sbjct: 67 LKDVYDD--GKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 124 Query: 155 HRDVKPHNVM-IDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDYQ 208 HRD+KP N++ +D LR+ D+G A+ E + + Y F PE+L Q Sbjct: 125 HRDLKPSNILYVDESGNPECLRICDFGFAKQLR--AENGLLMTPCYTANFVAPEVL-KRQ 181 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQ--LVRIAKVLGTEELYGYLKKYHIDL 266 YD D+WSLG +L +M+ PF +G + + L RI G L G Sbjct: 182 GYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGS--GKFTLSG--------- 230 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 N + VS A DL+ K+L D QRLTAK+ ++HP+ Sbjct: 231 ----------------------GNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVT 268 Query: 327 PVVK-EQSQPCADNAVLSSGLTAA 349 K QSQ + L G AA Sbjct: 269 QKDKLPQSQLSHQDLQLVKGAMAA 292 >2VN9-A nrPDB Length = 301 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 79/299 (26%), Positives = 144/299 (48%), Gaps = 49/299 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----KKKIKREVKILENLRGG 92 D+YQL +LG+G +S V + I + KI+ K +K++RE +I L+ Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH- 62 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLY--QILTDFDIRFYMYELLKALDYCH 149 NI++L D++ + LVF+ + + F+ + + ++ D + ++L+++++CH Sbjct: 63 PNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 120 Query: 150 SKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVD 206 GI+HRD+KP N+++ + K ++L D+GLA E Q + + + PE+L Sbjct: 121 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 Y +DMW+ G +L ++ PF+ + DQ LY +K D Sbjct: 181 -DPYGKPVDMWACGVILYILLVGYPPFW----DEDQ----------HRLYQQIKAGAYDF 225 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 W+ V+PEA DL++K+L + +R+TA EA++HP+ Sbjct: 226 -----------PSPEWDT---------VTPEAKDLINKMLTINPAKRITASEALKHPWI 264 >2X4F-A nrPDB Length = 373 Score = 94.4 bits (233), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 73/289 (25%), Positives = 134/289 (46%), Gaps = 48/289 (16%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKP---VKKKKIKREVKILENLRGGTNIIKLIDTV 102 LG G++ +V + ++ KI+K K+++K E+ ++ L N+I+L D Sbjct: 97 LGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHA-NLIQLYDAF 155 Query: 103 KDPVSKTPALVFEYINNTDF-----KQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRD 157 + LV EY++ + + Y LT+ D +M ++ + + + H I+H D Sbjct: 156 ES--KNDIVLVMEYVDGGELFDRIIDESYN-LTELDTILFMKQICEGIRHMHQMYILHLD 212 Query: 158 VKPHNVM-IDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDM 216 +KP N++ ++ K++++ID+GLA Y P ++ V + F PE +V+Y + DM Sbjct: 213 LKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPE-VVNYDFVSFPTDM 271 Query: 217 WSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQ 276 WS+G + ++ PF D A+ L N+IL Sbjct: 272 WSVGVIAYMLLSGLSPFLGDND--------AETL--------------------NNILAC 303 Query: 277 HSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 RW+ + E +S EA + + KLL + R++A EA++HP+ Sbjct: 304 ----RWD--LEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL 346 >4UZD-A nrPDB Length = 287 Score = 94.4 bits (233), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 81/323 (25%), Positives = 153/323 (47%), Gaps = 64/323 (19%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENLRG 91 +D+++ R LG+GK+ V+ A + + +K+L K + +++REV+I +LR Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYIN-NTDFKQLYQILTDFD---IRFYMYELLKALDY 147 NI++L D + L+ EY T +++L Q L+ FD Y+ EL AL Y Sbjct: 68 -PNILRLYGYFHD--ATRVYLILEYAPLGTVYREL-QKLSKFDEQRTATYITELANALSY 123 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 CHSK ++HRD+KP N+++ +L++ D+G + + P+ + + PE +++ Sbjct: 124 CHSKRVIHRDIKPENLLLG-SAGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPE-MIEG 180 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHG--QDNYDQLVRIAKVLGTEELYGYLKKYHID 265 +M+D +D+WSLG + + + PF Q+ Y ++ R+ Sbjct: 181 RMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRV------------------- 221 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 + F D + + +R DL+ +LL+++ QR +E +EHP+ Sbjct: 222 -EFTFPDFVTEGAR--------------------DLISRLLKHNPSQRPMLREVLEHPW- 259 Query: 326 YPVVKEQSQP--CADNAVLSSGL 346 + S+P C + ++ L Sbjct: 260 --ITANSSKPSNCQNKESAAAAL 280 >3D2K-A nrPDB Length = 272 Score = 94.4 bits (233), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 80/298 (26%), Positives = 142/298 (47%), Gaps = 55/298 (18%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK------IKREVKILENLRG 91 +D+ + R LG+GK+ V+ A + + +K+L + +K ++REV+I +LR Sbjct: 12 EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRH 71 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYIN-NTDFKQLYQILTDFD---IRFYMYELLKALDY 147 NI++L D + L+ EY T +++L Q L+ FD Y+ EL AL Y Sbjct: 72 -PNILRLYGYFHD--ATRVYLILEYAPLGTVYREL-QKLSRFDEQRTATYITELANALSY 127 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 CHSK ++HRD+KP N+++ +L++ D+G + + P+ + + PE +++ Sbjct: 128 CHSKRVIHRDIKPENLLLG-SNGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPE-MIEG 184 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 +M+D +D+WSLG + + P F + RI++V T Sbjct: 185 RMHDEKVDLWSLGVLCYEFLVGMPP-FEAHTYQETYRRISRVEFT--------------- 228 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 F D + + +R DL+ +LL+++ QRLT E +EHP+ Sbjct: 229 --FPDFVTEGAR--------------------DLISRLLKHNASQRLTLAEVLEHPWI 264 >3MN3-A nrPDB Length = 271 Score = 94.4 bits (233), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 106/203 (52%), Gaps = 12/203 (5%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENLRGG 92 +YQ+V+ LG G + +V A + T ++V +KI+ K + +I+RE+ L LR Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRH- 63 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDYCHS 150 +IIKL D +K +V EY N F + Q +++ + R + +++ A++YCH Sbjct: 64 PHIIKLYDVIKS--KDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHR 121 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 I+HRD+KP N+++D + +++ D+GL+ S + PE++ Sbjct: 122 HKIVHRDLKPENLLLD-EHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYA 180 Query: 211 DYSLDMWSLGCMLASMIFRREPF 233 +D+WS G +L M+ RR PF Sbjct: 181 GPEVDVWSCGVILYVMLCRRLPF 203 >3Q5I-A nrPDB Length = 504 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 86/334 (25%), Positives = 152/334 (45%), Gaps = 62/334 (18%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK----------------IKR 81 + Y VRKLG G Y EV + +K++K + K I Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95 Query: 82 EVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQ--ILTDFDIRFYM 138 E+ +L++L NIIKL D +D K LV E+ + F+Q+ + D M Sbjct: 96 EISLLKSL-DHPNIIKLFDVFEDK--KYFYLVTEFYEGGELFEQIINRHKFDECDAANIM 152 Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLAEFYHPAQEYNVRVASR 196 ++L + Y H I+HRD+KP N++++++ ++++D+GL+ F+ + R+ + Sbjct: 153 KQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTA 212 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY 256 Y+ PE+L + Y+ D+WS G ++ ++ P F GQ++ D + ++ K Sbjct: 213 YYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPP-FGGQNDQDIIKKVEK-------- 261 Query: 257 GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA 316 KY+ D FND W+N +S EA +L+ +L YD+ +R TA Sbjct: 262 ---GKYYFD----FND---------WKN---------ISDEAKELIKLMLTYDYNKRCTA 296 Query: 317 KEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR 350 +EA+ + ++ +D L L+ R Sbjct: 297 EEALNSRWIKKYANNINK--SDQKTLCGALSNMR 328 >3TAC-A nrPDB Length = 361 Score = 94.0 bits (232), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 80/310 (25%), Positives = 142/310 (45%), Gaps = 63/310 (20%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK--------KKKIKREVKILEN 88 +D Y+L +G+G +S V IN ++ VKI+ K + +KRE I Sbjct: 25 EDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHM 84 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRF---------YMY 139 L+ +I++L++T +VFE+++ D ++I+ D F YM Sbjct: 85 LKH-PHIVELLETYSS--DGMLYMVFEFMDGADL--CFEIVKRADAGFVYSEAVASHYMR 139 Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLA-EFYHPAQEYNVRVASR 196 ++L+AL YCH I+HRDVKPH V++ ++ ++L +G+A + RV + Sbjct: 140 QILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTP 199 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE-L 255 +F PE +V + Y +D+W G +L ++ PF+ GT+E L Sbjct: 200 HFMAPE-VVKREPYGKPVDVWGCGVILFILLSGCLPFY----------------GTKERL 242 Query: 256 YGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT 315 + + K ++P ++W + +S A DL+ ++L D +R+T Sbjct: 243 FEGIIKGKYKMNP-----------RQWSH---------ISESAKDLVRRMLMLDPAERIT 282 Query: 316 AKEAMEHPYF 325 EA+ HP+ Sbjct: 283 VYEALNHPWL 292 >2QNJ-A nrPDB Length = 328 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 78/289 (26%), Positives = 144/289 (49%), Gaps = 26/289 (8%) Query: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI-----LKPVKKKKIKREVKIL 86 P GN Y+L++ +G+G +++V A +I V +KI L P +K+ REV+I+ Sbjct: 9 PHIGN---YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIM 65 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLK 143 + L NI+KL + ++ KT L+ EY + D+ + + + + R +++ Sbjct: 66 KILNH-PNIVKLFEVIE--TEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVS 122 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 A+ YCH K I+HRD+K N+++D +++ D+G + + + + S + PEL Sbjct: 123 AVQYCHQKRIVHRDLKAENLLLDADM-NIKIADFGFSNEFTVGGKLDTFCGSPPYAAPEL 181 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK------VLGTEELYG 257 + +D+WSLG +L +++ P F GQ+ + R+ + + + Sbjct: 182 FQGKKYDGPEVDVWSLGVILYTLVSGSLP-FDGQNLKELRERVLRGKYRIPFYMSTDCEN 240 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSEN--RHLVSPEALDLLDK 304 LK++ + L+P L Q + RW N H E+ + V PE LD+ D+ Sbjct: 241 LLKRFLV-LNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPE-LDISDQ 287 >2HW6-A nrPDB Length = 307 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 84/314 (26%), Positives = 147/314 (46%), Gaps = 52/314 (16%) Query: 37 QDDYQLVRKL-GRGKYSEVFEAINITNNERVVVKILKPV---KKKKIKREVKILENLRGG 92 +D Y+L +L G G Y++V A+++ N + VKI++ + ++ REV+ L +G Sbjct: 11 EDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGN 70 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIR---FYMYELLKALDYCH 149 NI++LI+ +D LVFE + Q F+ R + ++ ALD+ H Sbjct: 71 KNILELIEFFEDDTRFY--LVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH 128 Query: 150 SKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLAEFYH--------PAQEYNVRVASRYFK 199 +KGI HRD+KP N++ + +K +++ D+ L E S + Sbjct: 129 TKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM 188 Query: 200 GPELLVDY----QMYDYSLDMWSLGCMLASMIFRREPFFH--GQD---NYDQLVRIAKVL 250 PE++ + YD D+WSLG +L M+ PF G D + ++ R+ + Sbjct: 189 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ-- 246 Query: 251 GTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDH 310 +L+ +++ + F D K W + +S EA DL+ KLL D Sbjct: 247 --NKLFESIQEGKYE----FPD-------KDWAH---------ISSEAKDLISKLLVRDA 284 Query: 311 QQRLTAKEAMEHPY 324 +QRL+A + ++HP+ Sbjct: 285 KQRLSAAQVLQHPW 298 >3DXN-A nrPDB Length = 287 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 88/315 (27%), Positives = 144/315 (45%), Gaps = 61/315 (19%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAIN-ITNNERVVVKILKPVKKKKIKR---------EVK 84 G D YQ V+KLG G Y EV + +T ER + K +KK + EV Sbjct: 18 GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAI----KIIKKSSVTTTSNSGALLDEVA 73 Query: 85 ILENLRGGTNIIKLIDTVKDPVSKTPALVFE-YINNTDFKQ--LYQILTDFDIRFYMYEL 141 +L+ L NI+KL + +D + LV E Y F + L Q ++ D M ++ Sbjct: 74 VLKQL-DHPNIMKLYEFFED--KRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQV 130 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFK 199 L Y H I+HRD+KP N++++ + + ++++D+GL+ + + R+ + Y+ Sbjct: 131 LSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYI 190 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE+L + YD D+WS G +L ++ P F GQ + + L R+ Sbjct: 191 APEVL--RKKYDEKCDVWSCGVILYILLCGYPP-FGGQTDQEILKRV------------- 234 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 +K DP W VS EA L+ +L Y+ +R++A+EA Sbjct: 235 EKGKFSFDP-----------PDWTQ---------VSDEAKQLVKLMLTYEPSKRISAEEA 274 Query: 320 MEHPYFYPVVKEQSQ 334 + HP+ +VK SQ Sbjct: 275 LNHPW---IVKFCSQ 286 >3HZT-A nrPDB Length = 467 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 93/330 (28%), Positives = 149/330 (45%), Gaps = 63/330 (19%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAIN-ITNNERVVVKILKPVKKKKIKR---------EVK 84 G D YQ V+KLG G Y EV + +T ER + K +KK + EV Sbjct: 1 GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAI----KIIKKSSVTTTSNSGALLDEVA 56 Query: 85 ILENLRGGTNIIKLIDTVKDPVSKTPALVFE-YINNTDFKQ--LYQILTDFDIRFYMYEL 141 +L+ L NI+KL + +D + LV E Y F + L Q ++ D M ++ Sbjct: 57 VLKQL-DHPNIMKLYEFFEDK--RNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQV 113 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFK 199 L Y H I+HRD+KP N++++ + + ++++D+GL+ + + R+ + Y+ Sbjct: 114 LSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYI 173 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE+L + YD D+WS G +L ++ P F GQ + + L R+ Sbjct: 174 APEVL--RKKYDEKCDVWSCGVILYILLCGYPP-FGGQTDQEILKRV------------- 217 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 +K DP W VS EA L+ +L Y+ +R++A+EA Sbjct: 218 EKGKFSFDP-----------PDWTQ---------VSDEAKQLVKLMLTYEPSKRISAEEA 257 Query: 320 MEHPYFYPVVKEQSQPCADNAVLSSGLTAA 349 + HP+ +VK SQ D V LT A Sbjct: 258 LNHPW---IVKFCSQKHTD--VGKHALTGA 282 >2Y7J-A nrPDB Length = 365 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 79/321 (24%), Positives = 144/321 (44%), Gaps = 60/321 (18%) Query: 28 EAHVPSWGNQDD----YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK------ 77 E +P W + Y +GRG S V ++ VKI++ ++ Sbjct: 80 EDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQL 139 Query: 78 -----KIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQ--IL 129 +RE IL + G +II LID+ + S LVF+ + + F L + L Sbjct: 140 EEVREATRRETHILRQVAGHPHIITLIDSYES--SSFMFLVFDLMRKGELFDYLTEKVAL 197 Query: 130 TDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY 189 ++ + R M LL+A+ + H+ I+HRD+KP N+++D ++RL D+G + P ++ Sbjct: 198 SEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNM-QIRLSDFGFSCHLEPGEKL 256 Query: 190 NVRVASRYFKGPELLV-----DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLV 244 + + PE+L + Y +D+W+ G +L +++ PF+H + Q++ Sbjct: 257 RELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRR----QIL 312 Query: 245 RIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDK 304 + ++ E Y Q S W++ S DL+ + Sbjct: 313 MLRMIM--EGQY-------------------QFSSPEWDD---------RSSTVKDLISR 342 Query: 305 LLRYDHQQRLTAKEAMEHPYF 325 LL+ D + RLTA++A++HP+F Sbjct: 343 LLQVDPEARLTAEQALQHPFF 363 >4RLP-A nrPDB Length = 288 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 81/305 (26%), Positives = 137/305 (44%), Gaps = 62/305 (20%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLI 99 ++L+R LG+G Y +VF+ +T + +K +KK I R K + + NI+ Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL--- 63 Query: 100 DTVKDP----------VSKTPALVFEYINNTD-FKQLYQ--ILTDFDIRFYMYELLKALD 146 + VK P L+ EY++ + F QL + I + FY+ E+ AL Sbjct: 64 EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALG 123 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLV 205 + H KGI++RD+KP N+M++HQ ++L D+GL E H + + + PE+L+ Sbjct: 124 HLHQKGIIYRDLKPENIMLNHQG-HVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 182 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 ++ ++D WSLG ++ M+ P F G++ + +I K ++ Sbjct: 183 R-SGHNRAVDWWSLGALMYDMLTGAPP-FTGENRKKTIDKILKC-------------KLN 227 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-----AKEAM 320 L P+ ++ EA DLL KLL+ + RL A E Sbjct: 228 LPPY------------------------LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQ 263 Query: 321 EHPYF 325 HP+F Sbjct: 264 AHPFF 268 >4L42-A nrPDB Length = 346 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 81/305 (26%), Positives = 137/305 (44%), Gaps = 62/305 (20%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLI 99 ++L+R LG+G Y +VF+ +T + +K +KK I R K + + NI+ Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL--- 76 Query: 100 DTVKDP----------VSKTPALVFEYINNTD-FKQLYQ--ILTDFDIRFYMYELLKALD 146 + VK P L+ EY++ + F QL + I + FY+ E+ AL Sbjct: 77 EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALG 136 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLV 205 + H KGI++RD+KP N+M++H Q ++L D+GL E H + + + PE+L+ Sbjct: 137 HLHQKGIIYRDLKPENIMLNH-QGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 195 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 ++ ++D WSLG ++ M+ P F G++ + +I K ++ Sbjct: 196 -RSGHNRAVDWWSLGALMYDMLTGAPP-FTGENRKKTIDKILKC-------------KLN 240 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-----AKEAM 320 L P+ ++ EA DLL KLL+ + RL A E Sbjct: 241 LPPY------------------------LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQ 276 Query: 321 EHPYF 325 HP+F Sbjct: 277 AHPFF 281 >1KOB-A nrPDB Length = 387 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 74/299 (24%), Positives = 131/299 (43%), Gaps = 52/299 (17%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK---PVKKKKIKREVKILENLRGGTN 94 D Y ++ +LG G + V + V K + P+ K +K E+ I+ L Sbjct: 51 DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEISIMNQLHH-PK 109 Query: 95 IIKLIDTVKDPVSKTPAL-------VFEYINNTDFKQLYQILTDFDIRFYMYELLKALDY 147 +I L D +D L +F+ I D+K +++ ++ YM + + L + Sbjct: 110 LINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYK-----MSEAEVINYMRQACEGLKH 164 Query: 148 CHSKGIMHRDVKPHNVMIDHQQ-KKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVD 206 H I+H D+KP N+M + ++ +++ID+GLA +P + V A+ F PE +VD Sbjct: 165 MHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPE-IVD 223 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 + + DMW++G + ++ P F G+D+ + L + Sbjct: 224 REPVGFYTDMWAIGVLGYVLLSGLSP-FAGEDDLETLQNV-------------------- 262 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 R WE + VSPEA D + LL+ + ++RLT +A+EHP+ Sbjct: 263 -----------KRCDWE--FDEDAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWL 308 >3F3Z-A nrPDB Length = 277 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 81/294 (27%), Positives = 137/294 (46%), Gaps = 47/294 (15%) Query: 40 YQLVRKLGRGKYSEVFEAINI-TNNERVVVKILKPVKKK--KIKREVKILENLRGGTNII 96 Y L +GRG + EV A+ T R KI K + + K+E++I+++L NII Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSL-DHPNII 69 Query: 97 KLIDTVKDPVSKTPALVFEYINNTD-FKQLY--QILTDFDIRFYMYELLKALDYCHSKGI 153 +L +T +D + LV E + F+++ ++ + D M ++L A+ YCH + Sbjct: 70 RLYETFED--NTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNV 127 Query: 154 MHRDVKPHNVMI--DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYD 211 HRD+KP N + D L+LID+GLA + P + +V + Y+ P++L +Y Sbjct: 128 AHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEG--LYG 185 Query: 212 YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFN 271 D WS G M+ ++ PF D+ + +++I + T Sbjct: 186 PECDEWSAGVMMYVLLCGYPPFSAPTDS-EVMLKIREGTFT------------------- 225 Query: 272 DILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 K W N VSP+A L+ +LL +QR+T+ +A+EH +F Sbjct: 226 -----FPEKDWLN---------VSPQAESLIRRLLTKSPKQRITSLQALEHEWF 265 >4JG6-A nrPDB Length = 355 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 81/297 (27%), Positives = 133/297 (44%), Gaps = 46/297 (15%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIK 97 D Y++ +G G YS I+ N VKI+ K+ + E++IL NII Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-EIEILLRYGQHPNIIT 93 Query: 98 LIDTVKDPVSKTPALVFEYINNTDF--KQLYQ-ILTDFDIRFYMYELLKALDYCHSKGIM 154 L D D K +V E + + K L Q ++ + ++ + K ++Y H++G++ Sbjct: 94 LKDVYDD--GKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVV 151 Query: 155 HRDVKPHNVM-IDHQQ--KKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDYQ 208 HRD+KP N++ +D + +R+ D+G A+ E + + Y F PE+L + Q Sbjct: 152 HRDLKPSNILYVDESGNPESIRICDFGFAKQLR--AENGLLMTPCYTANFVAPEVL-ERQ 208 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 YD + D+WSLG +L +M+ PF +G D+ EE+ + L Sbjct: 209 GYDAACDIWSLGVLLYTMLTGYTPFANGPDDT-----------PEEILARIGSGKFSLSG 257 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 + W + VS A DL+ K+L D QRLTA + HP+ Sbjct: 258 GY-----------WNS---------VSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 294 >5ES1-A nrPDB Length = 328 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 110/210 (52%), Gaps = 15/210 (7%) Query: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI-----LKPVKKKKIKREVKIL 86 P GN Y+L+R +G+G +++V A +I V +KI L P +K+ REV+I+ Sbjct: 12 PHVGN---YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIM 68 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLK 143 + L NI+KL + ++ KT LV EY + D+ + + + + R +++ Sbjct: 69 KGLNH-PNIVKLFEVIE--TEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVS 125 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 A+ YCH K I+HRD+K N+++D + +++ D+G + + + + S + PEL Sbjct: 126 AVHYCHQKNIVHRDLKAENLLLD-AEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPEL 184 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 + +D+WSLG +L +++ PF Sbjct: 185 FQGKKYDGPEVDIWSLGVILYTLVSGSLPF 214 >4MVF-A nrPDB Length = 506 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 78/307 (25%), Positives = 136/307 (44%), Gaps = 57/307 (18%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR---EVKILENLRGGT 93 +D Y + KLG+G Y V++ I+ N+ +K K + K I R E++I++ L Sbjct: 56 EDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDH-P 114 Query: 94 NIIKLIDTVKD--------PVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKAL 145 NI+KL +T ++ + L I N F T+ + M ++ A+ Sbjct: 115 NIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSF-------TEKNAATIMKQIFSAI 167 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 Y HS I+HRD+KP N + + K L++ID+GL++ + + + Y+ P++ Sbjct: 168 FYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQV 227 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 L YD D+WS G ++ +++ PF+ DN LKK Sbjct: 228 LD--GKYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNE-----------------VLKKV- 267 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 K+ E + + +S +A +L+ KLL Y+ +R T +EA+ HP Sbjct: 268 ----------------KKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHP 311 Query: 324 YFYPVVK 330 + + K Sbjct: 312 WITQMTK 318 >5KZ7-A nrPDB Length = 346 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 74/273 (27%), Positives = 135/273 (49%), Gaps = 23/273 (8%) Query: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI-----LKPVKKKKIKREVKIL 86 P GN Y+L++ +G+G +++V A +I + V VKI L +K+ REV+I+ Sbjct: 30 PHIGN---YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIM 86 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLK 143 + L NI+KL + ++ KT LV EY + D+ + + + + R +++ Sbjct: 87 KVL-NHPNIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 143 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 A+ YCH K I+HRD+K N+++D +++ D+G + + + + S + PEL Sbjct: 144 AVQYCHQKFIVHRDLKAENLLLDADM-NIKIADFGFSNEFTFGNKLDTFCGSPPYAAPEL 202 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK------VLGTEELYG 257 + +D+WSLG +L +++ P F GQ+ + R+ + + + Sbjct: 203 FQGKKYDGPEVDVWSLGVILYTLVSGSLP-FDGQNLKELRERVLRGKYRIPFYMSTDCEN 261 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSEN 290 LKK+ I L+P L Q + RW N H ++ Sbjct: 262 LLKKFLI-LNPSKRGTLEQIMKDRWMNVGHEDD 293 >4RGJ-A nrPDB Length = 520 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 80/302 (26%), Positives = 147/302 (48%), Gaps = 59/302 (19%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKIL--KPVKKKKIK----REVKILENLRGGT 93 Y+ ++ LG+G + EV + + +K++ K VK+K K REV++L+ L Sbjct: 62 YKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKML-DHI 120 Query: 94 NIIKLIDTVKDP-----VSK--TPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALD 146 NI+KL + +D VS T +F+ I K+ Y+I D + ++L + Sbjct: 121 NIMKLYEFFEDNNYYYLVSDVYTGGELFDEI--ISRKRFYEI----DAARIIKQILSGIT 174 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKK---LRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 Y H ++HRD+KP N++++ + K+ +++ID+GL+ + +++ ++ + Y+ P++ Sbjct: 175 YMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDV 234 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 L + YD D+WS G +L ++ P F+G + YD L ++ KY Sbjct: 235 L--HGTYDEKCDIWSCGVILY-ILLSGCPPFNGSNEYDILKKVEA-----------GKYT 280 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 DL P F I S +A DL+ K+L Y R++A++A+EH Sbjct: 281 FDL-PQFKKI---------------------SDKAKDLIKKMLMYTSAVRISARDALEHE 318 Query: 324 YF 325 + Sbjct: 319 WI 320 >5FG8-A nrPDB Length = 285 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 73/299 (24%), Positives = 145/299 (48%), Gaps = 49/299 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-----KKIKREVKILENLRGG 92 D+Y + +LG+G +S V + + KI+ K +K++RE +I L Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHH- 72 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLY--QILTDFDIRFYMYELLKALDYCH 149 NI++L D++++ LVF+ + + F+ + + ++ D + ++L+++++CH Sbjct: 73 PNIVRLHDSIQE--ENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCH 130 Query: 150 SKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVD 206 G++HRD+KP N+++ + K ++L D+GLA E Q + + + PE+L Sbjct: 131 QNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL-K 189 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 + Y S+D+W+ G +L ++ PF+ + DQ LY +K D Sbjct: 190 KEPYGKSVDIWACGVILYILLVGYPPFW----DEDQ----------HRLYSQIKAGAYD- 234 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 + W+ V+PEA +L++++L + +R+TA EA++HP+ Sbjct: 235 ----------YPSPEWDT---------VTPEAKNLINQMLTVNPNKRITAAEALKHPWI 274 >2VZ6-A nrPDB Length = 313 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 76/300 (25%), Positives = 142/300 (47%), Gaps = 49/300 (16%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----KKKIKREVKILENLRG 91 Q YQL +LG+G +S V + + + KI+ K +K++RE +I L+ Sbjct: 21 QSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 80 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLY--QILTDFDIRFYMYELLKALDYC 148 NI++L D++ + L+F+ + + F+ + + ++ D + ++L+A+ +C Sbjct: 81 -PNIVRLHDSISEEGHHY--LIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 137 Query: 149 HSKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLV 205 H G++HRD+KP N+++ + K ++L D+GLA E Q + + + PE+L Sbjct: 138 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 197 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 Y +D+W+ G +L ++ PF+ + DQ LY +K D Sbjct: 198 K-DPYGKPVDLWACGVILYILLVGYPPFW----DEDQ----------HRLYQQIKAGAYD 242 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 W+ V+PEA DL++K+L + +R+TA EA++HP+ Sbjct: 243 F-----------PSPEWDT---------VTPEAKDLINKMLTINPSKRITAAEALKHPWI 282 >2BDW-A nrPDB Length = 362 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 72/299 (24%), Positives = 145/299 (48%), Gaps = 48/299 (16%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-----KKIKREVKILENLRG 91 D+Y + +LG+G +S V ++ T KI+ K +K++RE +I L+ Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH 87 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLY--QILTDFDIRFYMYELLKALDYC 148 NI++L D++++ LVF+ + + F+ + + ++ D + ++L+++ YC Sbjct: 88 -PNIVRLHDSIQE--ESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYC 144 Query: 149 HSKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVD 206 HS GI+HR++KP N+++ + K ++L D+GLA + ++ ++ + + PE+L Sbjct: 145 HSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL-K 203 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 Y +D+W+ G +L ++ PF+ + DQ LY +K D Sbjct: 204 KDPYSKPVDIWACGVILYILLVGYPPFW----DEDQ----------HRLYAQIKAGAYD- 248 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 + W+ V+PEA L+D +L + ++R+TA +A++ P+ Sbjct: 249 ----------YPSPEWDT---------VTPEAKSLIDSMLTVNPKKRITADQALKVPWI 288 >3BHH-A nrPDB Length = 295 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 74/298 (24%), Positives = 144/298 (48%), Gaps = 49/298 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----KKKIKREVKILENLRGG 92 D+YQL +G+G +S V + + KI+ K +K++RE +I L+ Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH- 62 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLY--QILTDFDIRFYMYELLKALDYCH 149 +NI++L D++ + LVF+ + + F+ + + ++ D + ++L+A+ +CH Sbjct: 63 SNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 120 Query: 150 SKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVD 206 G++HRD+KP N+++ + K ++L D+GLA E Q + + + PE+L Sbjct: 121 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 + Y +D+W+ G +L ++ PF+ + DQ +LY +K D Sbjct: 181 -EAYGKPVDIWACGVILYILLVGYPPFW----DEDQ----------HKLYQQIKAGAYDF 225 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 W+ V+PEA +L++++L + +R+TA EA++HP+ Sbjct: 226 -----------PSPEWDT---------VTPEAKNLINQMLTINPAKRITAHEALKHPW 263 >3KK8-A nrPDB Length = 284 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 72/299 (24%), Positives = 145/299 (48%), Gaps = 48/299 (16%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-----KKIKREVKILENLRG 91 D+Y + +LG+G +S V ++ T KI+ K +K++RE +I L+ Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH 64 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLY--QILTDFDIRFYMYELLKALDYC 148 NI++L D++++ LVF+ + + F+ + + ++ D + ++L+++ YC Sbjct: 65 -PNIVRLHDSIQE--ESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYC 121 Query: 149 HSKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVD 206 HS GI+HR++KP N+++ + K ++L D+GLA + ++ ++ + + PE+L Sbjct: 122 HSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL-K 180 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 Y +D+W+ G +L ++ PF+ + DQ LY +K D Sbjct: 181 KDPYSKPVDIWACGVILYILLVGYPPFW----DEDQ----------HRLYAQIKAGAYD- 225 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 + W+ V+PEA L+D +L + ++R+TA +A++ P+ Sbjct: 226 ----------YPSPEWDT---------VTPEAKSLIDSMLTVNPKKRITADQALKVPWI 265 >5U6Y-A nrPDB Length = 461 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 75/297 (25%), Positives = 141/297 (47%), Gaps = 49/297 (16%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----KKKIKREVKILENLRGGTN 94 YQL +LG+G +S V + + + KI+ K +K++RE +I L+ N Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PN 60 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTD-FKQLY--QILTDFDIRFYMYELLKALDYCHSK 151 I++L D++ + L+F+ + + F+ + + ++ D + ++L+A+ +CH Sbjct: 61 IVRLHDSISEEGHHY--LIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 118 Query: 152 GIMHRDVKPHNVMIDHQQK--KLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQ 208 G++HRD+KP N+++ + K ++L D+GLA E Q + + + PE+L Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-D 177 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 Y +D+W+ G +L ++ PF+ + DQ LY +K D Sbjct: 178 PYGKPVDLWACGVILYILLVGYPPFW----DEDQ----------HRLYQQIKAGAYDF-- 221 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 W+ V+PEA DL++K+L + +R+TA EA++HP+ Sbjct: 222 ---------PSPEWDT---------VTPEAKDLINKMLTINPSKRITAAEALKHPWI 260 >3KN6-A nrPDB Length = 325 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 72/277 (25%), Positives = 132/277 (47%), Gaps = 36/277 (12%) Query: 44 RKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVK 103 + LG G +S + ++ +N+ VKI+ + ++E+ L+ G NI+KL + Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFH 76 Query: 104 DPVSKTPALVFEYINNTD-FKQLYQI--LTDFDIRFYMYELLKALDYCHSKGIMHRDVKP 160 D + LV E +N + F+++ + ++ + + M +L+ A+ + H G++HRD+KP Sbjct: 77 DQLHTF--LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 134 Query: 161 HNVMIDHQQKKL--RLIDWGLAEFYHP-AQEYNVRVASRYFKGPELLVDYQMYDYSLDMW 217 N++ + L ++ID+G A P Q + ++ PELL + YD S D+W Sbjct: 135 ENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL-NQNGYDESCDLW 193 Query: 218 SLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQH 277 SLG +L +M+ + PF ++D+ + + E+ +KK + Sbjct: 194 SLGVILYTMLSGQVPF----QSHDRSLTCTSAV---EIMKKIKKGDFSFE---------- 236 Query: 278 SRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL 314 + W+N VS EA DL+ LL D +RL Sbjct: 237 -GEAWKN---------VSQEAKDLIQGLLTVDPNKRL 263 >5UNP-A nrPDB Length = 369 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 83/346 (23%), Positives = 155/346 (44%), Gaps = 70/346 (20%) Query: 30 HVPSWGNQDDYQLVRKLGRGKYSEVFEAIN-ITNNERVVVKILKPVKKKKIKREVKILEN 88 HV W Q+ Y++V LG G + V + ++ RV +KI+K V+K K E Sbjct: 27 HVGDWL-QERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYK--------EA 77 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALV----FEYINNTDFKQLYQILTDFD----------- 133 R N+++ I+ KDP +K + F+Y + L+ FD Sbjct: 78 ARLEINVLEKINE-KDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYP 136 Query: 134 ---IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL------------------ 172 +R ++L +A+ + H + H D+KP N++ + +L Sbjct: 137 IHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAV 196 Query: 173 RLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREP 232 R++D+G A F H + ++ V++R+++ PE++++ + D+WS+GC++ + Sbjct: 197 RVVDFGSATFDH--EHHSTIVSTRHYRAPEVILELG-WSQPCDVWSIGCIIFEY-YVGFT 252 Query: 233 FFHGQDNYDQLVRIAKVLG--------TEELYGYLKKYHIDLDPHFNDILGQHSRKRWEN 284 F DN + L + ++LG Y + +D D N G++ R+ + Sbjct: 253 LFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDE--NTSAGRYVRENCKP 310 Query: 285 FIHSENRHLVSP-----EALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 R+L S + DL++ +L Y+ +RLT EA++HP+F Sbjct: 311 L----RRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF 352 >4C0T-A nrPDB Length = 974 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 67/233 (28%), Positives = 114/233 (48%), Gaps = 24/233 (10%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKKIKR---EVKILENL 89 N D++ ++LG G YS V A + ++ VK+L +K+KK+K E L L Sbjct: 264 NVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRL 323 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL---YQILTDFDIRFYMYELLKALD 146 +I L T +D S V +Y +N + L Y L + R + ++L A+ Sbjct: 324 SNRLGVISLYFTFQDKDSL--YFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP----AQEYNVRVASRYFKG-- 200 Y H G++HRD+KP N+++D + ++++ D+G A ++EY V V ++ F G Sbjct: 382 YMHDNGVIHRDLKPENILLDDKM-RIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTA 440 Query: 201 ----PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKV 249 PELL + + D+W+ GC++ MI + P F + Y +I K+ Sbjct: 441 EYVSPELL-ENKYCGKPGDVWAFGCIIYQMIAGKPP-FKATNEYLTFQKITKL 491 >6CMJ-A nrPDB Length = 321 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 65/231 (28%), Positives = 114/231 (49%), Gaps = 30/231 (12%) Query: 30 HVPSWGNQD-----DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR--- 81 HV G QD Y L ++G+G Y V A N +N +K+L KKK I++ Sbjct: 21 HVSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLS--KKKLIRQAGG 78 Query: 82 -------------EVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI 128 E+ IL+ L N++KL++ + DP +VFE +N ++ + Sbjct: 79 CIQPRGPIEQVYQEIAILKKLDH-PNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTL 137 Query: 129 --LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHP 185 L++ RFY +L+K ++Y H + I+HRD+KP N+++ + +++ D+G++ EF Sbjct: 138 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHIKIADFGVSNEFKGS 196 Query: 186 AQEYNVRVASRYFKGPELLVDYQ--MYDYSLDMWSLGCMLASMIFRREPFF 234 + V + F PE L + + +LD+W++G L +F + PF Sbjct: 197 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM 247 >2HAK-A nrPDB Length = 328 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 108/210 (51%), Gaps = 15/210 (7%) Query: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI-----LKPVKKKKIKREVKIL 86 P GN Y+L + +G+G +++V A ++ V VKI L P +K+ REV+I+ Sbjct: 12 PHIGN---YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIM 68 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLK 143 + L NI+KL + ++ KT LV EY + D+ + + + + R +++ Sbjct: 69 KILNH-PNIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 125 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 A+ YCH K I+HRD+K N+++D +++ D+G + + + + S + PEL Sbjct: 126 AVQYCHQKYIVHRDLKAENLLLDGDM-NIKIADFGFSNEFTVGNKLDTFCGSPPYAAPEL 184 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 + +D+WSLG +L +++ PF Sbjct: 185 FQGKKYDGPEVDVWSLGVILYTLVSGSLPF 214 >3SOA-A nrPDB Length = 444 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 73/299 (24%), Positives = 142/299 (47%), Gaps = 49/299 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----KKKIKREVKILENLRGG 92 ++YQL +LG+G +S V + + + I+ K +K++RE +I L+ Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH- 69 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLY--QILTDFDIRFYMYELLKALDYCH 149 NI++L D++ + L+F+ + + F+ + + ++ D + ++L+A+ +CH Sbjct: 70 PNIVRLHDSISEEGHHY--LIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 127 Query: 150 SKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVD 206 G++HR++KP N+++ + K ++L D+GLA E Q + + + PE+L Sbjct: 128 QMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK 187 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 Y +D+W+ G +L ++ PF+ + DQ LY +K D Sbjct: 188 -DPYGKPVDLWACGVILYILLVGYPPFW----DEDQ----------HRLYQQIKAGAYDF 232 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 W+ V+PEA DL++K+L + +R+TA EA++HP+ Sbjct: 233 -----------PSPEWDT---------VTPEAKDLINKMLTINPSKRITAAEALKHPWI 271 >3ORZ-A nrPDB Length = 316 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 80/313 (25%), Positives = 140/313 (44%), Gaps = 63/313 (20%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKKI---KREVKILENLRG 91 +D++ + LG G +S V A + + +KIL+ +K+ K+ RE ++ L Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-D 95 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYELLKALDYC 148 +KL +D + Y N + + + + FD RFY E++ AL+Y Sbjct: 96 HPFFVKLYFCFQD--DEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYL 153 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE---YNVRVASRYFKGPELLV 205 H KGI+HRD+KP N++++ + +++ D+G A+ P + N V + + PELL Sbjct: 154 HGKGIIHRDLKPENILLN-EDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT 212 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 + S D+W+LGC++ ++ PF G ++ + K++ E Y + +K+ Sbjct: 213 EKSACKSS-DLWALGCIIYQLVAGLPPFRAG----NEYLIFQKIIKLE--YDFPEKFF-- 263 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME---- 321 P+A DL++KLL D +RL +E ME Sbjct: 264 ------------------------------PKARDLVEKLLVLDATKRLGCEE-MEGYGP 292 Query: 322 ---HPYFYPVVKE 331 HP+F V E Sbjct: 293 LKAHPFFESVTWE 305 >5IG1-A nrPDB Length = 344 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 70/290 (24%), Positives = 135/290 (46%), Gaps = 48/290 (16%) Query: 46 LGRGKYSEVFEAINITNNERVVVKI-----LKPVKKKKIKREVKILENLRGGTNIIKLID 100 +G+G +S V +N E VK+ L+ + KIKRE+ I +L+ +I+ + Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQH-EHIVSMRR 83 Query: 101 TVKDPVSKTPALVFEYINNTD-FKQLY--QILTDFDIRFYMYELLKALDYCHSKGIMHRD 157 +D LVFEY++ + F ++ + + D M+++L AL +CHSK I+HRD Sbjct: 84 AFRD--ESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHRD 141 Query: 158 VKPHNVMIDHQ--QKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLD 215 +KP N+++ + +++ D+GLA Y + + PE++ YD ++D Sbjct: 142 LKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVP-YDTAVD 200 Query: 216 MWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILG 275 +W+ G +L ++ PF+ +D+ ++LY +K D Sbjct: 201 VWACGVILYILLVGYPPFWE-EDH-------------QKLYAQIKNCQYDF--------- 237 Query: 276 QHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 W++ V+ A +L+ +L + ++R T +E ++HP+ Sbjct: 238 --PSPEWDS---------VTTAAKELIKAMLEPNPKRRPTVQELLQHPWI 276 >4CZT-A nrPDB Length = 464 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 111/207 (53%), Gaps = 18/207 (8%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKIL---KPVKKK---KIKREVKILENLRGGT 93 Y+L R LG G +++V A N+ N + V +K++ K +K K +IKRE+ ++ ++ Sbjct: 13 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH-P 71 Query: 94 NIIKLIDTVKDPVSKTPA-LVFEYINNTD-FKQLYQI--LTDFDIRFYMYELLKALDYCH 149 N+I++ + + SKT V E++ + F ++ L + + R Y +L+ A+DYCH Sbjct: 72 NVIRMFEVM---ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 128 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE---YNVRVASRYFKGPELLVD 206 S+G+ HRD+KP N+++D L++ D+GL+ +E + + + PE++ + Sbjct: 129 SRGVYHRDLKPENLLLDANG-ALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 187 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPF 233 D+WS G +L ++ PF Sbjct: 188 KGYDGAKADLWSCGVILFVLMAGYLPF 214 >6QAU-A nrPDB Length = 280 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 108/219 (49%), Gaps = 27/219 (12%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR-------EVKILENLRGGTNIIKL 98 +G G ++ VF + + V +K + KK + + E+KIL+ L+ NI+ L Sbjct: 19 VGHGAFAVVFRGRHRQKTDWEVA--IKSINKKNLSKSQILLGKEIKILKELQH-ENIVAL 75 Query: 99 IDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHSKGIMH 155 D + P S LV EY N D Q L++ IR +++++ A+ HSKGI+H Sbjct: 76 YDVQELPNSVF--LVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIH 133 Query: 156 RDVKPHNVMIDHQQK--------KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 RD+KP N+++ + + ++++ D+G A + H S + PE+++ Sbjct: 134 RDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPEVIMS- 192 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRI 246 Q YD D+WS+G ++ + + PF Q N Q +R+ Sbjct: 193 QHYDAKADLWSIGTVIYQCLVGKPPF---QANSPQDLRM 228 >3UTO-A nrPDB Length = 573 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 78/321 (24%), Positives = 143/321 (44%), Gaps = 50/321 (15%) Query: 38 DDYQLVRKLGRGKYSEVFEAIN-ITNNERVVVKILKP--VKKKKIKREVKILENLRGGTN 94 D Y + +LG G + V T N ++ P K+ +++E++ + LR T Sbjct: 157 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRHPT- 215 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTD-FKQL---YQILTDFDIRFYMYELLKALDYCHS 150 ++ L D +D +++E+++ + F+++ + +++ + YM ++ K L + H Sbjct: 216 LVNLHDAFED--DNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE 273 Query: 151 KGIMHRDVKPHNVMIDHQQK-KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 +H D+KP N+M ++ +L+LID+GL P Q V + F PE + + + Sbjct: 274 NNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPE-VAEGKP 332 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 Y DMWS+G + ++ PF G +N D+ +R K +++D D Sbjct: 333 VGYYTDMWSVGVLSYILLSGLSPF--GGENDDETLRNVKSC----------DWNMD-DSA 379 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVV 329 F+ I S + D + KLL D R+T +A+EHP+ P Sbjct: 380 FSGI---------------------SEDGKDFIRKLLLADPNTRMTIHQALEHPWLTP-- 416 Query: 330 KEQSQPCADNAVLSSGLTAAR 350 + P D+ + SS T R Sbjct: 417 --GNAPGRDSQIPSSRYTKIR 435 >1KOA-A nrPDB Length = 491 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 78/321 (24%), Positives = 143/321 (44%), Gaps = 50/321 (15%) Query: 38 DDYQLVRKLGRGKYSEVFEAIN-ITNNERVVVKILKP--VKKKKIKREVKILENLRGGTN 94 D Y + +LG G + V T N ++ P K+ +++E++ + LR T Sbjct: 51 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRHPT- 109 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTD-FKQL---YQILTDFDIRFYMYELLKALDYCHS 150 ++ L D +D +++E+++ + F+++ + +++ + YM ++ K L + H Sbjct: 110 LVNLHDAFED--DNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE 167 Query: 151 KGIMHRDVKPHNVMIDHQQK-KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 +H D+KP N+M ++ +L+LID+GL P Q V + F PE + + + Sbjct: 168 NNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPE-VAEGKP 226 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 Y DMWS+G + ++ PF G +N D+ +R K +++D D Sbjct: 227 VGYYTDMWSVGVLSYILLSGLSPF--GGENDDETLRNVKSC----------DWNMD-DSA 273 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVV 329 F+ I S + D + KLL D R+T +A+EHP+ P Sbjct: 274 FSGI---------------------SEDGKDFIRKLLLADPNTRMTIHQALEHPWLTP-- 310 Query: 330 KEQSQPCADNAVLSSGLTAAR 350 + P D+ + SS T R Sbjct: 311 --GNAPGRDSQIPSSRYTKIR 329 >4D2V-A nrPDB Length = 356 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 76/310 (24%), Positives = 141/310 (45%), Gaps = 56/310 (18%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKP----VKKKKIKREVKILENLRGGTNI 95 Y+L +G G +++V A +I E V +KI+ +IK E++ L+NLR +I Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRH-QHI 89 Query: 96 IKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYCHSKG 152 +L ++ + +V EY D+ L++ + R +++ A+ Y HS+G Sbjct: 90 CQLYHVLE--TANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQG 147 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR--VASRYFKGPELLVDYQMY 210 HRD+KP N++ D + KL+LID+GL ++Y+++ + + PEL+ Sbjct: 148 YAHRDLKPENLLFD-EYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYL 206 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 D+WS+G +L ++ PF D+ +AK++ Sbjct: 207 GSEADVWSMGILLYVLMCGFLPF----DDDTAAALVAKIMR------------------- 243 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP-----YF 325 G++ +W +SP ++ LL ++L+ D ++R++ K + HP Y Sbjct: 244 ----GKYDVPKW-----------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYN 288 Query: 326 YPVVKEQSQP 335 YPV + P Sbjct: 289 YPVEWQSKNP 298 >6C9D-A nrPDB Length = 459 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 111/215 (51%), Gaps = 16/215 (7%) Query: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI-----LKPVKKKKIKREVKIL 86 P GN Y+L + +G+G +++V A ++ V VKI L P +K+ REV+I+ Sbjct: 18 PHIGN---YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIM 74 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLK 143 + L NI+KL + ++ KT LV EY + D+ + + + + R +++ Sbjct: 75 KIL-NHPNIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 131 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 A+ YCH K I+HRD+K N+++D +++ D+G + + + + S + PEL Sbjct: 132 AVQYCHQKYIVHRDLKAENLLLDGDM-NIKIADFGFSNEFTVGNKLDEFCGSPPYAAPEL 190 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQD 238 + +D+WSLG +L +++ P F GQ+ Sbjct: 191 FQGKKYDGPEVDVWSLGVILYTLVSGSLP-FDGQN 224 >4I6B-A nrPDB Length = 308 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 115/212 (54%), Gaps = 17/212 (8%) Query: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKI 85 P+ G + Y + LG+G +++ +E ++TNN+ KI+ KP +++KI +E++ Sbjct: 24 PTTGKR--YSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIE- 80 Query: 86 LENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELL 142 L + ++++ +D + ++ EY + + + +LT+ ++R+Y+ +++ Sbjct: 81 LHRILHHKHVVQFYHYFED--KENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIV 138 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVA-SRYFKGP 201 L Y H + I+HRD+K N I+ + +L++ D+GLA P + + + + P Sbjct: 139 SGLKYLHEQEILHRDLKLGNFFIN-ESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSP 197 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 E+L + Q + D+W+LGC++ +M+ R PF Sbjct: 198 EVL-NKQGHGAESDIWALGCVMYTMLLGRPPF 228 >1ZWS-A nrPDB Length = 288 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 79/312 (25%), Positives = 137/312 (43%), Gaps = 53/312 (16%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---------VKKKKIKREVKILE 87 +D Y + +LG G+++ V + + K +K V +++I+REV IL Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKA 144 + N+I L D ++ L+ E ++ DF + L++ + ++ ++L Sbjct: 71 QVLH-HNVITLHDVYENRTD--VVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQ---KKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 ++Y H+K I H D+KP N+M+ + ++LID+GLA E+ + F P Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 E+ V+Y+ DMWS+G + ++ PF G + L I V Sbjct: 188 EI-VNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITSV------------ 233 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 D D F F H+ S A D + KLL + ++RLT +EA+ Sbjct: 234 -SYDFDEEF--------------FSHT------SELAKDFIRKLLVKETRKRLTIQEALR 272 Query: 322 HPYFYPVVKEQS 333 HP+ PV +Q+ Sbjct: 273 HPWITPVDNQQA 284 >3RAW-A nrPDB Length = 381 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 74/334 (22%), Positives = 148/334 (44%), Gaps = 45/334 (13%) Query: 37 QDDYQLVRKLGRGKYSEVFEAIN-ITNNERVVVKILKPVKK--KKIKREVKILENLRGGT 93 Q+ Y++V LG G + +V E ++ +V +KI++ V K + + E+ +L+ ++ Sbjct: 50 QERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKD 109 Query: 94 NIIKLIDTVKDP---VSKTPALVFEYINNTDFKQL----YQILTDFDIRFYMYELLKALD 146 K + + + FE + F+ L +Q +R Y+L AL Sbjct: 110 KENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALR 169 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQ------------------KKLRLIDWGLAEFYHPAQE 188 + H + H D+KP N++ + + +R+ D+G A F H + Sbjct: 170 FLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDH--EH 227 Query: 189 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 + VA+R+++ PE++++ + D+WS+GC+L +R F +N + LV + K Sbjct: 228 HTTIVATRHYRPPEVILELG-WAQPCDVWSIGCILFEY-YRGFTLFQTHENREHLVMMEK 285 Query: 249 VLGT----------EELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEA 298 +LG ++ Y Y D + + ++ + + H+ + Sbjct: 286 ILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHV---QL 342 Query: 299 LDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ 332 DL+ ++L +D QR+T EA+ HP+F + E+ Sbjct: 343 FDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEE 376 >4YZB-A nrPDB Length = 491 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 74/306 (24%), Positives = 139/306 (45%), Gaps = 64/306 (20%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGT---- 93 D Y+ R LG+G + EV + + VK+ + K+++K++ L+ Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKV---ISKRQVKQKTDKELLLKEVELLKK 86 Query: 94 ----NIIKLIDTVKDP--------VSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYEL 141 NI+KL + +D V L E I+ F ++ D + ++ Sbjct: 87 LDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEV-------DAARIIRQV 139 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLAEFYHPAQEYNVRVASRYFK 199 L + Y H I+HRD+KP N+++++++K +R+ID+GL+ + ++ ++ + Y+ Sbjct: 140 LSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYI 199 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE+L + YD D+WS G +L ++ P F+G + +D L ++ K Sbjct: 200 APEVL--HGTYDEKCDVWSTGVILY-ILLSGCPPFNGANEFDILKKVEK----------- 245 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 K+ DL +W+ VS A DL+ K+L Y R++A++A Sbjct: 246 GKFTFDL-------------PQWKK---------VSEPAKDLIRKMLAYVPTMRISARDA 283 Query: 320 MEHPYF 325 +EH + Sbjct: 284 LEHEWL 289 >6CKI-A nrPDB Length = 316 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 82/322 (25%), Positives = 145/322 (45%), Gaps = 46/322 (14%) Query: 37 QDDYQLVRK-LGRGKYSEVFEAINITNNERVVVKILKPVK---KKKIKREVKILENLRGG 92 +D YQL LG G ++ V IN+ ++ VKI++ + ++ REV++L +G Sbjct: 11 EDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGH 70 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI-----LTDFDIRFYMYELLKALDY 147 N+++LI+ + LVFE + L I + + + ++ ALD+ Sbjct: 71 RNVLELIEFFE--EEDRFYLVFEKMRGGSI--LSHIHKRRHFNELEASVVVQDVASALDF 126 Query: 148 CHSKGIMHRDVKPHNVMIDH--QQKKLRLIDWGLAEFYH--------PAQEYNVRVASRY 197 H+KGI HRD+KP N++ +H Q +++ D+GL E S Sbjct: 127 LHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAE 186 Query: 198 FKGPELLVDY----QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTE 253 + PE++ + +YD D+WSLG +L ++ PF G+ D Sbjct: 187 YMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFV-GRCGSD------------ 233 Query: 254 ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR 313 G+ + + P ++L + ++ F + H +S A DL+ KLL D +QR Sbjct: 234 --CGWDRG---EACPACQNMLFESIQEGKYEFPDKDWAH-ISCAAKDLISKLLVRDAKQR 287 Query: 314 LTAKEAMEHPYFYPVVKEQSQP 335 L+A + ++HP+ E + P Sbjct: 288 LSAAQVLQHPWVQGCAPENTLP 309 >5WAX-A nrPDB Length = 310 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 71/301 (23%), Positives = 135/301 (44%), Gaps = 41/301 (13%) Query: 31 VPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILEN 88 +P + D Y+LVR +G G + N + + V VK ++ +K + ++RE+ + Sbjct: 4 MPIMHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHRS 63 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQI--LTDFDIRFYMYELLKAL 145 LR NII+ + + P A+V EY + + F+++ ++ + RF+ +L+ + Sbjct: 64 LRH-PNIIRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 120 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQK-KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL 204 YCHS + HRD+K N ++D +L++ D+G ++ + V + + PE+L Sbjct: 121 SYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 180 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 + + D+WS G L M+ PF + + I ++LG + Y I Sbjct: 181 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQ--------YSI 232 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 +++H +SPE DL+ ++ + R+T E HP+ Sbjct: 233 ------------------PDYVH------ISPECQDLISRIFVANPATRITIPEIRNHPW 268 Query: 325 F 325 F Sbjct: 269 F 269 >2V7O-A nrPDB Length = 336 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 74/298 (24%), Positives = 144/298 (48%), Gaps = 49/298 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----KKKIKREVKILENLRGG 92 DDYQL +LG+G +S V + T + KI+ K +K++RE +I L+ Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKH- 89 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLY--QILTDFDIRFYMYELLKALDYCH 149 NI++L D++ + LVF+ + + F+ + + ++ D ++++L+++++ H Sbjct: 90 PNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIH 147 Query: 150 SKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVD 206 I+HRD+KP N+++ + K ++L D+GLA E Q + + + PE+L Sbjct: 148 QHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRK 207 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 Y +D+W+ G +L ++ PF+ + DQ +LY +K D Sbjct: 208 -DPYGKPVDIWACGVILYILLVGYPPFW----DEDQ----------HKLYQQIKAGAYDF 252 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 W+ V+PEA +L++++L + +R+TA +A++HP+ Sbjct: 253 -----------PSPEWDT---------VTPEAKNLINQMLTINPAKRITADQALKHPW 290 >5YKS-A nrPDB Length = 377 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 107/209 (51%), Gaps = 12/209 (5%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK-----REVKILENLRGGTN 94 Y L + LGRG ++ V A ++ E+V VK++ K + +EV+ ++ L N Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMK-LVQHPN 95 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDF----KQLYQILTDFDIRFYMYELLKALDYCHS 150 I++L + + D +K L+ E + D + + L + + Y +++ A+ YCH Sbjct: 96 IVRLYEVI-DTQTKL-YLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHK 153 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 ++HRD+KP NV+ +Q ++L D+G + + P ++ S + PE+L+ + Sbjct: 154 LHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYD 213 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDN 239 ++D+WSLG +L ++ + PF D+ Sbjct: 214 APAVDIWSLGVILFMLVCGQPPFQEANDS 242 >4YNZ-A nrPDB Length = 342 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 62/217 (28%), Positives = 112/217 (51%), Gaps = 14/217 (6%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK-----KIKREVKILENLRGGTN 94 Y+L + LG+G+ V I+ ++V +KI+ K K++RE+ IL+ L + Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILK-LIEHPH 70 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQI--LTDFDIRFYMYELLKALDYCHSK 151 ++KL D ++ K LV E+++ + F L + LT + R + +++ ALD+CHS Sbjct: 71 VLKLHDVYEN--KKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSH 128 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYD 211 I HRD+KP N+++D ++ +R+ D+G+A S ++ PE++ + Sbjct: 129 SICHRDLKPENLLLD-ERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 187 Query: 212 YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 D+WS G +L +++ PF DN QL+ K Sbjct: 188 RKADVWSCGVILFALLVGALPF--DDDNLRQLLEKVK 222 >5TUR-A nrPDB Length = 404 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 107/216 (49%), Gaps = 17/216 (7%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK---------KKKIKREVKILE 87 + YQ+ LG G + V+ I +++N V +K ++ + ++ EV +L+ Sbjct: 126 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 185 Query: 88 NLRGG-TNIIKLIDTVKDPVSKTPALVFEYINNT----DFKQLYQILTDFDIRFYMYELL 142 + G + +I+L+D + P S L+ E DF L + R + +++L Sbjct: 186 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 243 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 202 +A+ +CH+ G++HRD+K N++ID + +L+LID+G Y +R + PE Sbjct: 244 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPE 302 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQD 238 + ++ + S +WSLG +L M+ PF H ++ Sbjct: 303 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 338 >2J90-A nrPDB Length = 304 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 74/307 (24%), Positives = 137/307 (44%), Gaps = 53/307 (17%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---------VKKKKIKREVKILE 87 +D Y++ +LG G+++ V + + K +K V +++I+REV IL Sbjct: 25 EDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILR 84 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKA 144 +R NII L D ++ L+ E ++ DF + LT+ + ++ ++L Sbjct: 85 EIRH-PNIITLHDIFENKTD--VVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDG 141 Query: 145 LDYCHSKGIMHRDVKPHNVMI---DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 + Y HSK I H D+KP N+M+ + +++LID+G+A E+ + F P Sbjct: 142 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAP 201 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 E +V+Y+ DMWS+G + ++ PF G+ + L I+ V Sbjct: 202 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GETKQETLTNISAV-----------N 248 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 Y D + +F++ S A D + +LL D ++R+T +++E Sbjct: 249 YDFD-EEYFSN---------------------TSELAKDFIRRLLVKDPKRRMTIAQSLE 286 Query: 322 HPYFYPV 328 H + + Sbjct: 287 HSWIKAI 293 >3BGP-A nrPDB Length = 333 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 107/216 (49%), Gaps = 17/216 (7%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK---------KKKIKREVKILE 87 + YQ+ LG G + V+ I +++N V +K ++ + ++ EV +L+ Sbjct: 55 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 114 Query: 88 NLRGG-TNIIKLIDTVKDPVSKTPALVFEYINNT----DFKQLYQILTDFDIRFYMYELL 142 + G + +I+L+D + P S L+ E DF L + R + +++L Sbjct: 115 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 172 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 202 +A+ +CH+ G++HRD+K N++ID + +L+LID+G Y +R + PE Sbjct: 173 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV-YTDFDGTRVYSPPE 231 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQD 238 + ++ + S +WSLG +L M+ PF H ++ Sbjct: 232 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 267 >4B8L-A nrPDB Length = 286 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 74/296 (25%), Positives = 134/296 (45%), Gaps = 53/296 (17%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENLRG 91 DD+ + R LG+GK+ V+ A N + +K+L K + +++RE++I +LR Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIR---FYMYELLKALDYC 148 NI+++ + D K L+ E+ + + Q FD + +M EL AL YC Sbjct: 75 -PNILRMYNYFHD--RKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYC 131 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQ 208 H + ++HRD+KP N+++ + + +L++ D+G + + P+ + + PE +++ + Sbjct: 132 HERKVIHRDIKPENLLMGY-KGELKIADFGWS-VHAPSLRRRTMCGTLDYLPPE-MIEGK 188 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 +D +D+W G + + P F + + RI +++D Sbjct: 189 THDEKVDLWCAGVLCYEFLVGMPP-FDSPSHTETHRRI-----------------VNVDL 230 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 F L S+ DL+ KLLRY QRL K MEHP+ Sbjct: 231 KFPPFLSDGSK--------------------DLISKLLRYHPPQRLPLKGVMEHPW 266 >2YAB-A nrPDB Length = 361 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 79/312 (25%), Positives = 136/312 (43%), Gaps = 53/312 (16%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---------VKKKKIKREVKILE 87 +D Y + +LG G+++ V + + K +K V +++I+REV IL Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILR 70 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKA 144 + NII L D ++ L+ E ++ DF + L++ + ++ ++L Sbjct: 71 QVLH-PNIITLHDVYENRTD--VVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQ---KKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 ++Y H+K I H D+KP N+M+ + ++LID+GLA E+ + F P Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 E +V+Y+ DMWS+G + ++ PF G + L I V Sbjct: 188 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAV------------ 233 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 D D F S+ L A D + KLL + ++RLT +EA+ Sbjct: 234 -SYDFDEEF----------------FSQTSEL----AKDFIRKLLVKETRKRLTIQEALR 272 Query: 322 HPYFYPVVKEQS 333 HP+ PV +Q+ Sbjct: 273 HPWITPVDTQQA 284 >4RC3-A nrPDB Length = 289 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 107/216 (49%), Gaps = 17/216 (7%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK---------KKKIKREVKILE 87 + YQ+ LG G + V+ I +++N V +K ++ + ++ EV +L+ Sbjct: 11 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 70 Query: 88 NLRGG-TNIIKLIDTVKDPVSKTPALVFEYINNT----DFKQLYQILTDFDIRFYMYELL 142 + G + +I+L+D + P S L+ E DF L + R + +++L Sbjct: 71 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 128 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 202 +A+ +CH+ G++HRD+K N++ID + +L+LID+G Y +R + PE Sbjct: 129 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV-YTDFDGTRVYSPPE 187 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQD 238 + ++ + S +WSLG +L M+ PF H ++ Sbjct: 188 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 223 >2A27-A nrPDB Length = 321 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 78/312 (25%), Positives = 136/312 (43%), Gaps = 53/312 (16%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---------VKKKKIKREVKILE 87 +D Y + +LG G+++ V + + K +K V +++I+REV IL Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKA 144 + N+I L D ++ L+ E ++ DF + L++ + ++ ++L Sbjct: 71 QVLHH-NVITLHDVYENRTD--VVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQ---KKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 ++Y H+K I H D+KP N+M+ + ++LID+GLA E+ + F P Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 E +V+Y+ DMWS+G + ++ PF G + L I V Sbjct: 188 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAV------------ 233 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 D D F S+ L A D + KLL + ++RLT +EA+ Sbjct: 234 -SYDFDEEF----------------FSQTSEL----AKDFIRKLLVKETRKRLTIQEALR 272 Query: 322 HPYFYPVVKEQS 333 HP+ PV +Q+ Sbjct: 273 HPWITPVDNQQA 284 >2WO6-A nrPDB Length = 382 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 64/230 (27%), Positives = 122/230 (53%), Gaps = 24/230 (10%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILENLRGGTNI 95 D Y++ +G+G + +V +A + E V +KI+K K + + EV++LE + Sbjct: 54 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 113 Query: 96 IK--LIDTVKDPVSKTP-ALVFEYIN--------NTDFKQLYQILTDFDIRFYMYELLKA 144 +K ++ + + + LVFE ++ NT+F+ + LT R + ++ A Sbjct: 114 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLT----RKFAQQMCTA 169 Query: 145 LDYCHSK--GIMHRDVKPHNVMI-DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 L + + I+H D+KP N+++ + ++ ++++D+G + Q + SR+++ P Sbjct: 170 LLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSS--CQLGQRIYQYIQSRFYRSP 227 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG 251 E+L+ YD ++DMWSLGC+L M EP F G + DQ+ +I +VLG Sbjct: 228 EVLLGMP-YDLAIDMWSLGCILVEM-HTGEPLFSGANEVDQMNKIVEVLG 275 >1TKI-A nrPDB Length = 321 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 67/295 (22%), Positives = 138/295 (46%), Gaps = 45/295 (15%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGTNI 95 + Y + LGRG++ V + ++ + + K +K + +K+E+ IL N+ NI Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISIL-NIARHRNI 63 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCHSK 151 + L ++ + + ++FE+I+ D + L + +I Y++++ +AL + HS Sbjct: 64 LHLHESFESM--EELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSH 121 Query: 152 GIMHRDVKPHNVMIDHQQKK-LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 I H D++P N++ ++ +++I++G A P + + + + PE+ + + Sbjct: 122 NIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVH-QHDVV 180 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 + DMWSLG ++ ++ PF + Q+ I ++ E Y D + F Sbjct: 181 STATDMWSLGTLVYVLLSGINPFL--AETNQQI--IENIMNAE--------YTFD-EEAF 227 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 +I S EA+D +D+LL + + R+TA EA++HP+ Sbjct: 228 KEI---------------------SIEAMDFVDRLLVKERKSRMTASEALQHPWL 261 >2JD5-A nrPDB Length = 373 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 92/350 (26%), Positives = 163/350 (46%), Gaps = 57/350 (16%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKIL----------E 87 Y LVRKLG G +S V+ A ++ NN V +KI++ V + + E+K+L E Sbjct: 21 YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKE 80 Query: 88 NLRGGTNIIKLIDTV--KDPVSKTPALVFEYINNTDFKQLYQILTDFD--------IRFY 137 + G +I+KL+D K P +VFE + + L ++ ++ ++ Sbjct: 81 DSMGANHILKLLDHFNHKGPNGVHVVMVFEVLG----ENLLALIKKYEHRGIPLIYVKQI 136 Query: 138 MYELLKALDYCHSK-GIMHRDVKPHNVMID-----HQQKKLRLIDWGLAEFYHPAQEYNV 191 +LL LDY H + GI+H D+KP NV+++ ++++ D G A +Y + Y Sbjct: 137 SKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYD--EHYTN 194 Query: 192 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI---FRREP---FFHGQDNYDQLVR 245 + +R ++ PE+L+ + D+WS C++ +I F EP + +D+ D + + Sbjct: 195 SIQTREYRSPEVLLGAP-WGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDD-DHIAQ 252 Query: 246 IAKVLGTEELYGYLKKYHIDLDPHFND--ILGQHSR-KRW-------ENFIHSENRHLVS 295 I ++LG EL YL + FN +L S+ K W E + S++ + Sbjct: 253 IIELLG--ELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDE---A 307 Query: 296 PEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSG 345 E D L +L+ D ++R A + HP+ + + D + SG Sbjct: 308 KEISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSG 357 >2WQN-A nrPDB Length = 310 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 58/221 (26%), Positives = 110/221 (49%), Gaps = 19/221 (8%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVK------ILKPVKKKKIKREVKILENLRGG 92 ++++ +K+GRG++SEV+ A + + V +K ++ + +E+ +L+ L Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQL-NH 91 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTD-------FKQLYQILTDFDIRFYMYELLKAL 145 N+IK + + +V E + D FK+ +++ + + Y +L AL Sbjct: 92 PNVIKYYASFIE--DNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSAL 149 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP-AQEYNVRVASRYFKGPELL 204 ++ HS+ +MHRD+KP NV I ++L D GL F+ + V + Y+ PE + Sbjct: 150 EHMHSRRVMHRDIKPANVFIT-ATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI 208 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR 245 + Y++ D+WSLGC+L M + PF+ + N L + Sbjct: 209 HE-NGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCK 248 >5JZN-A nrPDB Length = 280 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 79/295 (26%), Positives = 131/295 (44%), Gaps = 48/295 (16%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK----IKREVKILENLRGGTNI 95 Y++ R +G G ++ V E + + +KI+K K + I+ EV IL ++ NI Sbjct: 21 YKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKH-PNI 79 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQI--LTDFDIRFYMYELLKALDYCHSKG 152 + LI+ + P LV E + D F + T+ D +Y L A+ Y HS Sbjct: 80 VLLIEEMDVPTELY--LVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLN 137 Query: 153 IMHRDVKPHNVMI-DHQ--QKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 I+HRD+KP N+++ +HQ K L+L D+GLA Y V + + PE++ + Sbjct: 138 IVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVD-GPLYTV-CGTPTYVAPEIIAETG- 194 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 Y +D+W+ G + ++ PF D DQ E L+ + +D Sbjct: 195 YGLKVDIWAAGVITYILLCGFPPFRGSGD--DQ----------EVLFDQILMGQVDFPSP 242 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 + W+N VS A +L+ +L D QR +A + +EHP+ Sbjct: 243 Y-----------WDN---------VSDSAKELITMMLLVDVDQRFSAVQVLEHPW 277 >2OZA-A nrPDB Length = 356 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 80/317 (25%), Positives = 141/317 (44%), Gaps = 47/317 (14%) Query: 38 DDYQLVRK-LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNII 96 DDY++ + LG G +V + N E+ +K+L+ K + REV++ +I+ Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--REVELHWRASQCPHIV 74 Query: 97 KLIDTVKDPVS--KTPALVFEYINNTD-FKQLY----QILTDFDIRFYMYELLKALDYCH 149 +++D ++ + K +V E ++ + F ++ Q T+ + M + +A+ Y H Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 150 SKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 S I HRDVKP N++ ++ L+L D+G A+ + Y+ PE+L Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 193 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFF--HGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 + YD S DMWSLG ++ ++ PF+ HG + I+ + T G +Y Sbjct: 194 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHG-------LAISPGMKTRIRMG---QYEFP 243 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 +P +++ VS E L+ LL+ + QR+T E M HP+ Sbjct: 244 -NPEWSE---------------------VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 281 Query: 326 YPVVKEQSQPCADNAVL 342 K P + VL Sbjct: 282 MQSTKVPQTPLHTSRVL 298 >1NY3-A nrPDB Length = 400 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 80/317 (25%), Positives = 141/317 (44%), Gaps = 47/317 (14%) Query: 38 DDYQLVRK-LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNII 96 DDY++ + LG G +V + N E+ +K+L+ K + REV++ +I+ Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--REVELHWRASQCPHIV 118 Query: 97 KLIDTVKDPVS--KTPALVFEYINNTD-FKQLY----QILTDFDIRFYMYELLKALDYCH 149 +++D ++ + K +V E ++ + F ++ Q T+ + M + +A+ Y H Sbjct: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 Query: 150 SKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 S I HRDVKP N++ ++ L+L D+G A+ + Y+ PE+L Sbjct: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 237 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFF--HGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 + YD S DMWSLG ++ ++ PF+ HG + I+ + T G +Y Sbjct: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHG-------LAISPGMKTRIRMG---QYEFP 287 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 +P +++ VS E L+ LL+ + QR+T E M HP+ Sbjct: 288 -NPEWSE---------------------VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 Query: 326 YPVVKEQSQPCADNAVL 342 K P + VL Sbjct: 326 MQSTKVPQTPLHTSRVL 342 >1PHK-A nrPDB Length = 298 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 75/318 (23%), Positives = 138/318 (43%), Gaps = 57/318 (17%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK------------KKKIKRE 82 G ++Y+ LGRG S V I+ + VKI+ ++ +E Sbjct: 14 GFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKE 73 Query: 83 VKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQ--ILTDFDIRFYMY 139 V IL + G NII+L DT + + LVF+ + + F L + L++ + R M Sbjct: 74 VDILRKVSGHPNIIQLKDTYE--TNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMR 131 Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK 199 LL+ + H I+HRD+KP N+++D ++L D+G + P ++ + + Sbjct: 132 ALLEVICALHKLNIVHRDLKPENILLDDDM-NIKLTDFGFSCQLDPGEKLREVCGTPSYL 190 Query: 200 GPELLV-----DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE 254 PE++ ++ Y +DMWS G ++ +++ PF+H + Q++ + ++ Sbjct: 191 APEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRK----QMLMLRMIMSGNY 246 Query: 255 LYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL 314 +G W+++ S DL+ + L Q+R Sbjct: 247 QFG---------------------SPEWDDY---------SDTVKDLVSRFLVVQPQKRY 276 Query: 315 TAKEAMEHPYFYPVVKEQ 332 TA+EA+ HP+F V E+ Sbjct: 277 TAEEALAHPFFQQYVVEE 294 >6FYV-A nrPDB Length = 337 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 78/324 (24%), Positives = 155/324 (47%), Gaps = 45/324 (13%) Query: 40 YQLVRKLGRGKYSEVFEAIN-ITNNERVVVKILKPVKK--KKIKREVKILENLRGG--TN 94 Y++V LG G + +V E I+ + V VKI+K V + + + E+++LE+L + Sbjct: 16 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS 75 Query: 95 IIKLIDTVK--DPVSKTPALVFEYI--NNTDFKQLYQILT-DFD-IRFYMYELLKALDYC 148 + + + ++ D +VFE + + DF + L D IR Y++ +++++ Sbjct: 76 VFRCVQMLEWFDHHGHV-CIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFL 134 Query: 149 HSKGIMHRDVKPHNVMI---------------DHQQKK---LRLIDWGLAEFYHPAQEYN 190 H + H D+KP N++ D + K ++++D+G A + + ++ Sbjct: 135 HHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY--DDEHHS 192 Query: 191 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVL 250 V++R+++ PE+++ + D+WS+GC+L + F D+ + L + ++L Sbjct: 193 TLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEY-YLGFTVFQTHDSKEHLAMMERIL 250 Query: 251 GTEELY--------GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEAL-DL 301 G + Y +D D H + G++ R+R + H E L DL Sbjct: 251 GPIPQHMIQKTRKRKYFHHNQLDWDEHSS--AGRYVRRRCKPLKEFMLCHDEEHEKLFDL 308 Query: 302 LDKLLRYDHQQRLTAKEAMEHPYF 325 + ++L YD QR+T EA++HP+F Sbjct: 309 VRRMLEYDPTQRITLDEALQHPFF 332 >4WNO-A nrPDB Length = 287 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 56/212 (26%), Positives = 109/212 (51%), Gaps = 22/212 (10%) Query: 40 YQLVRK--LGRGKYSEVFEAIN-ITNNERVVVKIL--KPVKKKK--IKREVKILENLRGG 92 ++ RK +G G ++ VF+ + ++ V VK + K + K + + +E+KIL+ L+ Sbjct: 18 FEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKH- 76 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINN---TDFKQLYQILTDFDIRFYMYELLKALDYCH 149 NI+ L D + ++ + LV EY N D+ + L++ IR ++ ++ A+ H Sbjct: 77 ENIVALYDFQE--MANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLH 134 Query: 150 SKGIMHRDVKPHNVMIDH--------QQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 SKGI+HRD+KP N+++ + ++++ D+G A + S + P Sbjct: 135 SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAP 194 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 E+++ Q YD D+WS+G ++ + + PF Sbjct: 195 EVIMS-QHYDGKADLWSIGTIVYQCLTGKAPF 225 >2Z7Q-A nrPDB Length = 321 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 63/235 (26%), Positives = 121/235 (51%), Gaps = 21/235 (8%) Query: 30 HVPSWGNQDD---YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKRE---- 82 HV + + D ++L++ LG+G + +VF +T + + +K +KK +K Sbjct: 17 HVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVR 76 Query: 83 VKILENLRGGTN---IIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQ--ILTDFDIRF 136 K+ ++ N ++KL + L+ +++ D F +L + + T+ D++F Sbjct: 77 TKMERDILADVNHPFVVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKF 134 Query: 137 YMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE--FYHPAQEYNVRVA 194 Y+ EL LD+ HS GI++RD+KP N+++D ++ ++L D+GL++ H + Y+ Sbjct: 135 YLAELALGLDHLHSLGIIYRDLKPENILLD-EEGHIKLTDFGLSKEAIDHEKKAYSFCGT 193 Query: 195 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKV 249 Y PE +V+ Q + +S D WS G ++ M+ P F G+D + + I K Sbjct: 194 VEYM-APE-VVNRQGHSHSADWWSYGVLMFEMLTGSLP-FQGKDRKETMTLILKA 245 >5XZW-A nrPDB Length = 471 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 76/309 (24%), Positives = 135/309 (43%), Gaps = 60/309 (19%) Query: 39 DYQLVRKL-GRGKYSEVFEAINITNNERVVVKILKPVK----KKKIKREVKILENLRGGT 93 D+ ++ ++ G+G ++ V +AI T + VKI+ K + RE+++L+ L Sbjct: 196 DFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNH-P 254 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINN---TDFKQLYQILTDFDIRFYMYELLKALDYCHS 150 I++L +D +++ +V E+++ DF + + + R ++L A+ Y HS Sbjct: 255 RIVRLKGFYED--TESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS 312 Query: 151 KGIMHRDVKPHNVMIDHQQKKL-RLIDWGLAEFYHPAQEYNVRVASRYFKGPELL----- 204 GI HRD+KP N++I+ L ++ D+GLA+ + + PE++ Sbjct: 313 MGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDT 372 Query: 205 -------VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY- 256 + Y +DMWS+GC++ ++ PF DQL K +G + Sbjct: 373 SVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF--SGSTQDQLY---KQIGRGSYHE 427 Query: 257 GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA 316 G LK + I S EA D +D LL+ D R TA Sbjct: 428 GPLKDFRI------------------------------SEEARDFIDSLLQVDPNNRSTA 457 Query: 317 KEAMEHPYF 325 +A+ HP+ Sbjct: 458 AKALNHPWI 466 >2YCR-A nrPDB Length = 323 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 82/341 (24%), Positives = 148/341 (43%), Gaps = 64/341 (18%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----------KKKIKREVKI 85 +D+Y + + LG G EV A ++V +KI+ K ++ E++I Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68 Query: 86 LENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLY--QILTDFDIRFYMYELL 142 L+ L IIK+ + ++ +V E + + F ++ + L + + Y Y++L Sbjct: 69 LKKLNHPC-IIKIKNFFD---AEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML 124 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 A+ Y H GI+HRD+KP NV++ Q++ +++ D+G ++ + + Sbjct: 125 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 184 Query: 201 PELLVDYQM--YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258 PE+LV Y+ ++D WSLG +L + PF Sbjct: 185 PEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSE----------------------- 221 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE 318 + + L G++ NFI E VS +ALDL+ KLL D + R T +E Sbjct: 222 -HRTQVSLKDQITS--GKY------NFI-PEVWAEVSEKALDLVKKLLVVDPKARFTTEE 271 Query: 319 AMEHPY---------FYPVVKEQSQPCADNAVLSSGLTAAR 350 A+ HP+ F ++ E+++ A VL+ T+ + Sbjct: 272 ALRHPWLQDEDMKRKFQDLLSEENESTAKPQVLAQPSTSRK 312 >3KA0-A nrPDB Length = 320 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 80/317 (25%), Positives = 141/317 (44%), Gaps = 47/317 (14%) Query: 38 DDYQLVRK-LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNII 96 DDY++ + LG G +V + N E+ +K+L+ K + REV++ +I+ Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--REVELHWRASQCPHIV 72 Query: 97 KLIDTVKDPVS--KTPALVFEYINNTD-FKQLY----QILTDFDIRFYMYELLKALDYCH 149 +++D ++ + K +V E ++ + F ++ Q T+ + M + +A+ Y H Sbjct: 73 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 132 Query: 150 SKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 S I HRDVKP N++ ++ L+L D+G A+ + Y+ PE+L Sbjct: 133 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVL-GP 191 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFF--HGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 + YD S DMWSLG ++ ++ PF+ HG + I+ + T G +Y Sbjct: 192 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHG-------LAISPGMKTRIRMG---QYEFP 241 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 +P +++ VS E L+ LL+ + QR+T E M HP+ Sbjct: 242 -NPEWSE---------------------VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 279 Query: 326 YPVVKEQSQPCADNAVL 342 K P + VL Sbjct: 280 MQSTKVPQTPLHTSRVL 296 >2BRG-A nrPDB Length = 297 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 61/222 (27%), Positives = 105/222 (47%), Gaps = 28/222 (12%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIK 97 +D+ LV+ LG G Y EV A+N E V VKI+ +KR V EN++ I K Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVD------MKRAVDCPENIKKEICINK 60 Query: 98 LID---TVK----DPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDY 147 +++ VK L EY + + + + + D + + ++L+ + Y Sbjct: 61 MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY 120 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR-------VASRYFKG 200 H GI HRD+KP N+++D ++ L++ D+GLA + YN R + + Sbjct: 121 LHGIGITHRDIKPENLLLD-ERDNLKISDFGLATVFR----YNNRERLLNKMCGTLPYVA 175 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQ 242 PELL + + +D+WS G +L +M+ P+ D+ + Sbjct: 176 PELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQE 217 >4CQG-A nrPDB Length = 331 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 71/305 (23%), Positives = 140/305 (45%), Gaps = 54/305 (17%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKP----VKKKKIKREVKILENLRGGTNI 95 Y+L +G G +++V A ++ E V +KI+ ++K E+ L++LR +I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRH-QHI 69 Query: 96 IKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYCHSKG 152 +L ++ +V EY D+ L++ + R ++L A+ Y HS+G Sbjct: 70 CQLYHVLE--TKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQG 127 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR--VASRYFKGPELLVDYQMY 210 HRD+KP N++ D + KL+LID+GL ++Y+++ S + PEL+ Sbjct: 128 YAHRDLKPENLLFD-ENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYL 186 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 D+WS+G +L ++ PF D+ + + K++ Sbjct: 187 GSEADVWSMGILLYVLMCGFLPF----DDDNVMALYKKIMR------------------- 223 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVK 330 G++ +W +SP ++ LL ++L+ D ++R++ + + HP+ V++ Sbjct: 224 ----GKYEVPKW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPW---VMQ 265 Query: 331 EQSQP 335 + S P Sbjct: 266 DYSCP 270 >6FD3-A nrPDB Length = 300 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 69/292 (23%), Positives = 126/292 (43%), Gaps = 46/292 (15%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVK---ILKPVKKKKIKREVKILENLRGGTNII 96 Y K+G+G V+ A++I + V +K + + KK+ I E+ ++ + NI+ Sbjct: 24 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKN-PNIV 82 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDYCHSKGIM 154 +D+ V +V EY+ + + + I E L+ALD+ HS ++ Sbjct: 83 NYLDSYL--VGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI 140 Query: 155 HRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNVRVASRYFKGPELLVDYQMYDYS 213 HRD+K N+++ ++L D+G P Q + + V + Y+ PE +V + Y Sbjct: 141 HRDIKSDNILL-GMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE-VVTRKAYGPK 198 Query: 214 LDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDI 273 +D+WSLG M M+ P+ + +N + + + GT EL Sbjct: 199 VDIWSLGIMAIEMVEGEPPYLN--ENPLRALYLIATNGTPEL------------------ 238 Query: 274 LGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 +N +S D L++ L D +R +AKE ++HP+ Sbjct: 239 ---------------QNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 275 >1FOT-A nrPDB Length = 318 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 76/307 (24%), Positives = 140/307 (45%), Gaps = 57/307 (18%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKKIK--REVKILENLRGGT 93 D+Q++R LG G + V + N +K+LK V+ K+++ + +++ ++ Sbjct: 7 DFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHP 66 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYELLKALDYCHS 150 II++ T +D ++ ++ +YI + L + F +FY E+ AL+Y HS Sbjct: 67 FIIRMWGTFQD--AQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHS 124 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 K I++RD+KP N+++D + +++ D+G A+ Y P Y + Y PE +V + Y Sbjct: 125 KDIIYRDLKPENILLD-KNGHIKITDFGFAK-YVPDVTYTLCGTPDYI-APE-VVSTKPY 180 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 + S+D WS G ++ M+ PF+ + + + K+L E + P F Sbjct: 181 NKSIDWWSFGILIYEMLAGYTPFY----DSNTMKTYEKILNAE----------LRFPPFF 226 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL-----TAKEAMEHPYF 325 N+ + DLL +L+ D QRL ++ HP+F Sbjct: 227 NE------------------------DVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWF 262 Query: 326 YPVVKEQ 332 VV E+ Sbjct: 263 KEVVWEK 269 >4CFF-A nrPDB Length = 571 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 96/203 (47%), Gaps = 13/203 (6%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK------KIKREVKILENLRGGT 93 Y L LG G + +V + +V VKIL K + KIKRE++ L+ R Sbjct: 35 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH-P 93 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYCHS 150 +IIKL + P +V EY++ D+ + + + + R ++L A+DYCH Sbjct: 94 HIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 151 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 ++HRD+KP NV++D ++ D+GL+ + S + PE++ Sbjct: 152 HMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 210 Query: 211 DYSLDMWSLGCMLASMIFRREPF 233 +D+WS G +L +++ PF Sbjct: 211 GPEVDIWSCGVILYALLCGTLPF 233 >2W4O-A nrPDB Length = 349 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 74/294 (25%), Positives = 136/294 (46%), Gaps = 43/294 (14%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-PVKKKKIKREVKILENLRGGTNI 95 D +++ +LGRG S V+ + +K+LK V KK ++ E+ +L L NI Sbjct: 52 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRL-SHPNI 110 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQ--ILTDFDIRFYMYELLKALDYCHSKG 152 IKL + + P + LV E + + F ++ + ++ D + ++L+A+ Y H G Sbjct: 111 IKLKEIFETPTEIS--LVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENG 168 Query: 153 IMHRDVKPHNVM--IDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 I+HRD+KP N++ L++ D+GL++ + + PE+L Y Sbjct: 169 IVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCA-Y 227 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 +DMWS+G + ++ EPF+ + DQ + ++L E + + P + Sbjct: 228 GPEVDMWSVGIITYILLCGFEPFY--DERGDQFM-FRRILNCEYYF---------ISPWW 275 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 ++ VS A DL+ KL+ D ++RLT +A++HP+ Sbjct: 276 DE---------------------VSLNAKDLVRKLIVLDPKKRLTTFQALQHPW 308 >5EZV-A nrPDB Length = 560 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 96/203 (47%), Gaps = 13/203 (6%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK------KIKREVKILENLRGGT 93 Y L LG G + +V + +V VKIL K + KIKRE++ L+ R Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH-P 88 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYCHS 150 +IIKL + P +V EY++ D+ + + + + R ++L A+DYCH Sbjct: 89 HIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 146 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 ++HRD+KP NV++D ++ D+GL+ + S + PE++ Sbjct: 147 HMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 205 Query: 211 DYSLDMWSLGCMLASMIFRREPF 233 +D+WS G +L +++ PF Sbjct: 206 GPEVDIWSCGVILYALLCGTLPF 228 >5UUU-A nrPDB Length = 547 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 78/310 (25%), Positives = 134/310 (43%), Gaps = 63/310 (20%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNI 95 +D+ + R +GRG + EV+ + +K L KK+IK +K E L I Sbjct: 196 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD---KKRIK--MKQGETLALNERI 250 Query: 96 -IKLIDTVKDP-------VSKTP---ALVFEYINNTDFK---QLYQILTDFDIRFYMYEL 141 + L+ T P TP + + + +N D + + ++ D+RFY E+ Sbjct: 251 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 310 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 + L++ H++ +++RD+KP N+++D + +R+ D GLA + + + V + + P Sbjct: 311 ILGLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPH-ASVGTHGYMAP 368 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFF-HGQDNYDQLVRIAKVLGTEELYGYLK 260 E+L YD S D +SLGCML ++ PF H + ++ R+ + E Sbjct: 369 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE------- 421 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL-----T 315 L F SPE LL+ LL+ D +RL Sbjct: 422 -----LPDSF------------------------SPELRSLLEGLLQRDVNRRLGCLGRG 452 Query: 316 AKEAMEHPYF 325 A+E E P+F Sbjct: 453 AQEVKESPFF 462 >4D28-A nrPDB Length = 446 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 63/206 (30%), Positives = 109/206 (52%), Gaps = 18/206 (8%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKI------LKPVKKKKIKREVKILENLRGGT 93 Y++ R +G G +++V A N + V +KI LK +IKRE+ I++ +R Sbjct: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH-P 69 Query: 94 NIIKLIDTVKDPVSKTPA-LVFEYINNTD-FKQLYQI--LTDFDIRFYMYELLKALDYCH 149 NI++L + + SK+ +V E++ + F ++ L + + R Y +L+ A+ +CH Sbjct: 70 NIVRLYEVL---ASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCH 126 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-YNVRVASRYFKGPELLVDYQ 208 SKG+ HRD+KP N+++D L++ D+GL+ E N + + PE+L Q Sbjct: 127 SKGVYHRDLKPENLLLD-TNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVL-SGQ 184 Query: 209 MYDYS-LDMWSLGCMLASMIFRREPF 233 YD S D+WS G +L ++ PF Sbjct: 185 GYDGSAADIWSCGVILFVILAGYLPF 210 >5X8I-B nrPDB Length = 346 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 81/326 (24%), Positives = 160/326 (49%), Gaps = 49/326 (15%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNER-VVVKILKPVKK--KKIKREVKILENLR-----G 91 Y++V LG G + +V E I+ R V VKI+K V + + + E+++LE+L Sbjct: 15 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 74 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYI--NNTDFKQLYQILT-DFD-IRFYMYELLKALDY 147 +++++ + +VFE + + DF + L D IR Y++ K++++ Sbjct: 75 TFRCVQMLEWFEH--HGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNF 132 Query: 148 CHSKGIMHRDVKPHNVM-------------IDHQQKKL-----RLIDWGLAEFYHPAQEY 189 HS + H D+KP N++ I ++ L +++D+G A + + + Sbjct: 133 LHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY--DDEHH 190 Query: 190 NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKV 249 + V++R+++ PE+++ + D+WS+GC+L + F D+ + L + ++ Sbjct: 191 STLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEY-YLGFTVFPTHDSKEHLAMMERI 248 Query: 250 LGTEELYGYLKK------YHIDLDPHFNDILGQH---SRKRWENFIHSENRHLVSPEAL- 299 LG + K +H LD + G++ + K + F+ S++ V E L Sbjct: 249 LGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQD---VEHERLF 305 Query: 300 DLLDKLLRYDHQQRLTAKEAMEHPYF 325 DL+ K+L YD +R+T +EA++HP+F Sbjct: 306 DLIQKMLEYDPAKRITLREALKHPFF 331 >4JXF-A nrPDB Length = 266 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 69/299 (23%), Positives = 137/299 (45%), Gaps = 54/299 (18%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENLRG 91 +D+++ LG+G ++ V+ A +I V +K++ K ++++ EVKI L+ Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTD----FKQLYQILTDFDIRFYMYELLKALDY 147 + I++L + +D S LV E +N + K + ++ + R +M++++ + Y Sbjct: 67 PS-ILELYNYFED--SNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLY 123 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVD 206 HS GI+HRD+ N+++ + +++ D+GLA + P +++ + + PE + Sbjct: 124 LHSHGILHRDLTLSNLLLT-RNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-IAT 181 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 + D+WSLGCM +++ R PF T+ + L K Sbjct: 182 RSAHGLESDVWSLGCMFYTLLIGRPPF-----------------DTDTVKNTLNKV---- 220 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 +L + E +S EA DL+ +LLR + RL+ ++HP+ Sbjct: 221 ------VLADY-----------EMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM 262 >4X7Q-B nrPDB Length = 312 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 55/224 (24%), Positives = 104/224 (46%), Gaps = 31/224 (13%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL--------KPVKKK-KIKREVKILE 87 + +Y+L LG+G + VF +T+ +V +K++ P+ EV +L Sbjct: 30 EAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLW 89 Query: 88 NLRGG---TNIIKLID----------TVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI 134 + G +I+L+D ++ P+ +F+YI L + Sbjct: 90 KVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQD--LFDYITEKG------PLGEGPS 141 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVA 194 R + +++ A+ +CHS+G++HRD+K N++ID ++ +LID+G H + Y Sbjct: 142 RCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLH-DEPYTDFDG 200 Query: 195 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQD 238 +R + PE + +Q + +WSLG +L M+ PF Q+ Sbjct: 201 TRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQE 244 >5YV8-A nrPDB Length = 298 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 60/233 (25%), Positives = 110/233 (47%), Gaps = 40/233 (17%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR---------------- 81 + Y L ++G+G Y V A N +N +K+L KKK I++ Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLS--KKKLIRQAGFPRRPPPRGTRPAP 70 Query: 82 ---------------EVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY 126 E+ IL+ L N++KL++ + DP +VFE +N ++ Sbjct: 71 GGCIQPRGPIEQVYQEIAILKKLDH-PNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVP 129 Query: 127 QI--LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFY 183 + L++ RFY +L+K ++Y H + I+HRD+KP N+++ + +++ D+G++ EF Sbjct: 130 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHIKIADFGVSNEFK 188 Query: 184 HPAQEYNVRVASRYFKGPELLVDYQ--MYDYSLDMWSLGCMLASMIFRREPFF 234 + V + F PE L + + +LD+W++G L +F + PF Sbjct: 189 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM 241 >5D9K-A nrPDB Length = 330 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 61/227 (26%), Positives = 118/227 (51%), Gaps = 18/227 (7%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKRE----VKILENLR 90 + ++L++ LG+G + +VF I+ ++ + +K +KK +K K+ ++ Sbjct: 27 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDIL 86 Query: 91 GGTN---IIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQ--ILTDFDIRFYMYELLKA 144 N I+KL + L+ +++ D F +L + + T+ D++FY+ EL A Sbjct: 87 VEVNHPFIVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 144 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE--FYHPAQEYNVRVASRYFKGPE 202 LD+ HS GI++RD+KP N+++D ++ ++L D+GL++ H + Y+ Y PE Sbjct: 145 LDHLHSLGIIYRDLKPENILLD-EEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYM-APE 202 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKV 249 +V+ + + S D WS G ++ M+ P F G+D + + I K Sbjct: 203 -VVNRRGHTQSADWWSFGVLMFEMLTGTLP-FQGKDRKETMTMILKA 247 >3PVW-A nrPDB Length = 695 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 78/308 (25%), Positives = 134/308 (43%), Gaps = 63/308 (20%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNI-I 96 +D+ + R +GRG + EV+ + +K L KK+IK +K E L I + Sbjct: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD---KKRIK--MKQGETLALNERIML 243 Query: 97 KLIDTVKDP-------VSKTP---ALVFEYINNTDFK---QLYQILTDFDIRFYMYELLK 143 L+ T P TP + + + +N D + + ++ D+RFY E++ Sbjct: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 L++ H++ +++RD+KP N+++D + +R+ D GLA + + + V + + PE+ Sbjct: 304 GLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPH-ASVGTHGYMAPEV 361 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFF-HGQDNYDQLVRIAKVLGTEELYGYLKKY 262 L YD S D +SLGCML ++ PF H + ++ R+ + E Sbjct: 362 LQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE--------- 412 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL-----TAK 317 L F SPE LL+ LL+ D +RL A+ Sbjct: 413 ---LPDSF------------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQ 445 Query: 318 EAMEHPYF 325 E E P+F Sbjct: 446 EVKESPFF 453 >3A8W-A nrPDB Length = 345 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 105/219 (47%), Gaps = 22/219 (10%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI---------KREVKILENL 89 D+ L+R +GRG Y++V + + +R+ +K VKK+ + + E + E Sbjct: 10 DFDLLRVIGRGSYAKVL-LVRLKKTDRIYA--MKVVKKELVNDDEDIDWVQTEKHVFEQA 66 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFK---QLYQILTDFDIRFYMYELLKALD 146 ++ L + V EY+N D Q + L + RFY E+ AL+ Sbjct: 67 SNHPFLVGLHSCFQ--TESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALN 124 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLV 205 Y H +GI++RD+K NV++D + ++L D+G+ E P + + + PE+L Sbjct: 125 YLHERGIIYRDLKLDNVLLD-SEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILR 183 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPF--FHGQDNYDQ 242 + Y +S+D W+LG ++ M+ R PF DN DQ Sbjct: 184 G-EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQ 221 >3HKO-A nrPDB Length = 345 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 86/351 (24%), Positives = 143/351 (40%), Gaps = 103/351 (29%) Query: 37 QDDYQLVRKLGRGKYSEV----------FEAINITNNERVVVKILKPVKKKKIKREVKIL 86 Q Y L +G+G Y V AI I N ++ + + P ++IK EV+++ Sbjct: 25 QKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKI--RQINPKDVERIKTEVRLM 82 Query: 87 ENLR-------------------------GGTNIIKL------------IDTVKDPVSKT 109 + L GG + KL +D VK + Sbjct: 83 KKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPC 142 Query: 110 PALVFEYINNT--------DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPH 161 P E IN + DF Q +++++ M ++ AL Y H++GI HRD+KP Sbjct: 143 PECNEEAINGSIHGFRESLDFVQREKLISNI-----MRQIFSALHYLHNQGICHRDIKPE 197 Query: 162 NVMIDHQQK-KLRLIDWGLA-EFYHPAQ-EY---NVRVASRYFKGPELL-VDYQMYDYSL 214 N + + +++L+D+GL+ EFY EY + + YF PE+L + Y Sbjct: 198 NFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKC 257 Query: 215 DMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDIL 274 D WS G +L ++ P F G ++ D I++VL + + +P++N Sbjct: 258 DAWSAGVLLHLLLMGAVP-FPGVNDADT---ISQVLNKKLCFE---------NPNYN--- 301 Query: 275 GQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 ++SP A DLL LL + +R A A++HP+ Sbjct: 302 ------------------VLSPLARDLLSNLLNRNVDERFDAMRALQHPWI 334 >5F9E-A nrPDB Length = 353 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 81/312 (25%), Positives = 142/312 (45%), Gaps = 65/312 (20%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIK 97 +D++L + LG+G + +VF A N+ +K LK ++V ++++ T + K Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALK--------KDVVLMDDDVECTMVEK 70 Query: 98 LIDTV--KDP----------VSKTPALVFEYINNTDFKQLYQILTDFDIR---FYMYELL 142 + ++ + P + V EY+N D Q FD+ FY E++ Sbjct: 71 RVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEII 130 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGP 201 L + HSKGI++RD+K N+++D + +++ D+G+ E + N + + P Sbjct: 131 LGLQFLHSKGIVYRDLKLDNILLD-KDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAP 189 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 E+L+ Q Y++S+D WS G +L M+ + P FHGQD EEL+ Sbjct: 190 EILLG-QKYNHSVDWWSFGVLLYEMLIGQSP-FHGQDE-------------EELF----- 229 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK-EAM 320 + I +D F RW + EA DLL KL + ++RL + + Sbjct: 230 HSIRMDNPF--------YPRW-----------LEKEAKDLLVKLFVREPEKRLGVRGDIR 270 Query: 321 EHPYFYPVVKEQ 332 +HP F + E+ Sbjct: 271 QHPLFREINWEE 282 >4B6L-A nrPDB Length = 281 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 51/200 (25%), Positives = 102/200 (51%), Gaps = 15/200 (7%) Query: 44 RKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENLRGGTNIIK 97 R LG+G ++ +EA + VK++ KP +++KI E+++ +L+ +I++ Sbjct: 15 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQH-RHIVR 73 Query: 98 LIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHSKGIM 154 +D + + E + +++ L + ++R+Y+ ++L L Y H +GI+ Sbjct: 74 FSHHFED--ADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGIL 131 Query: 155 HRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYS 213 HRD+K N I + +L++ D+GL A P Q + + PE+L+ Q + Sbjct: 132 HRDLKLGNFFIT-ENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLR-QGHGPE 189 Query: 214 LDMWSLGCMLASMIFRREPF 233 D+WSLGC++ +++ PF Sbjct: 190 ADVWSLGCVMYTLLCGSPPF 209 >1U5R-A nrPDB Length = 348 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 58/204 (28%), Positives = 103/204 (50%), Gaps = 18/204 (8%) Query: 43 VRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK------IKREVKILENLRGGTNII 96 +R++G G + V+ A ++ N+E V +K + K+ I +EV+ L+ LR I Sbjct: 59 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 118 Query: 97 KLIDTVKDPVSKTPALVFEYI--NNTDFKQLYQ-ILTDFDIRFYMYELLKALDYCHSKGI 153 +++ T LV EY + +D ++++ L + +I + L+ L Y HS + Sbjct: 119 YRGCYLRE---HTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNM 175 Query: 154 MHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE--LLVDYQMYD 211 +HRDVK N+++ + ++L D+G A PA + V + Y+ PE L +D YD Sbjct: 176 IHRDVKAGNILLS-EPGLVKLGDFGSASIMAPANSF---VGTPYWMAPEVILAMDEGQYD 231 Query: 212 YSLDMWSLGCMLASMIFRREPFFH 235 +D+WSLG + R+ P F+ Sbjct: 232 GKVDVWSLGITCIELAERKPPLFN 255 >3I6U-A nrPDB Length = 419 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 75/307 (24%), Positives = 134/307 (43%), Gaps = 55/307 (17%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----------KKKIKREVKI 85 +D+Y + + LG G EV A ++V ++I+ K ++ E++I Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEI 193 Query: 86 LENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLY--QILTDFDIRFYMYELL 142 L+ L IIK+ + ++ +V E + + F ++ + L + + Y Y++L Sbjct: 194 LKKLNHPC-IIKIKNFFD---AEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML 249 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 A+ Y H GI+HRD+KP NV++ Q++ +++ D+G ++ + + Sbjct: 250 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 309 Query: 201 PELLVDYQM--YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258 PE+LV Y+ ++D WSLG +L + PF Sbjct: 310 PEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSE----------------------- 346 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE 318 + + L G++ NFI E VS +ALDL+ KLL D + R T +E Sbjct: 347 -HRTQVSLKDQITS--GKY------NFI-PEVWAEVSEKALDLVKKLLVVDPKARFTTEE 396 Query: 319 AMEHPYF 325 A+ HP+ Sbjct: 397 ALRHPWL 403 >2GCD-A nrPDB Length = 309 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 104/204 (50%), Gaps = 18/204 (8%) Query: 43 VRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK------IKREVKILENLRGGTNII 96 +R++G G + V+ A ++ N+E V +K + K+ I +EV+ L+ LR I Sbjct: 20 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 79 Query: 97 KLIDTVKDPVSKTPALVFEYI--NNTDFKQLYQ-ILTDFDIRFYMYELLKALDYCHSKGI 153 +++ T LV EY + +D ++++ L + +I + L+ L Y HS + Sbjct: 80 YRGCYLRE---HTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNM 136 Query: 154 MHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV--DYQMYD 211 +HRDVK N+++ + ++L D+G A PA + V + Y+ PE+++ D YD Sbjct: 137 IHRDVKAGNILLS-EPGLVKLGDFGSASIMAPANSF---VGTPYWMAPEVILAMDEGQYD 192 Query: 212 YSLDMWSLGCMLASMIFRREPFFH 235 +D+WSLG + R+ P F+ Sbjct: 193 GKVDVWSLGITCIELAERKPPLFN 216 >4PDS-A nrPDB Length = 347 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 75/309 (24%), Positives = 134/309 (43%), Gaps = 60/309 (19%) Query: 39 DYQLVRKL-GRGKYSEVFEAINITNNERVVVKILKPVK----KKKIKREVKILENLRGGT 93 D+ ++ ++ G+G ++ V +AI T + VKI+ K + RE+++L+ L Sbjct: 31 DFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNH-P 89 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINN---TDFKQLYQILTDFDIRFYMYELLKALDYCHS 150 I++L +D +++ +V E+++ DF + + + R ++L A+ Y HS Sbjct: 90 RIVRLKGFYED--TESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS 147 Query: 151 KGIMHRDVKPHNVMIDHQQKKL-RLIDWGLAEFYHPAQEYNVRVASRYFKGPELL----- 204 GI HRD+KP N++I+ L ++ +GLA+ + + PE++ Sbjct: 148 MGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDT 207 Query: 205 -------VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY- 256 + Y +DMWS+GC++ ++ PF DQL K +G + Sbjct: 208 SVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF--SGSTQDQLY---KQIGRGSYHE 262 Query: 257 GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA 316 G LK + I S EA D +D LL+ D R TA Sbjct: 263 GPLKDFRI------------------------------SEEARDFIDSLLQVDPNNRSTA 292 Query: 317 KEAMEHPYF 325 +A+ HP+ Sbjct: 293 AKALNHPWI 301 >3H4J-B nrPDB Length = 336 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 55/202 (27%), Positives = 100/202 (49%), Gaps = 12/202 (5%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVK-ILKPVKKK-----KIKREVKILENLRGGT 93 Y + LG G + +V A + ++V +K I + + KK +++RE+ L+ LR Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRH-P 69 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI--LTDFDIRFYMYELLKALDYCHSK 151 +IIKL D + P +V EY F + + +T+ + R + +++ A++YCH Sbjct: 70 HIIKLYDVITTPTDIV--MVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRH 127 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYD 211 I+HRD+KP N+++D +++ D+GL+ S + PE++ Sbjct: 128 KIVHRDLKPENLLLD-DNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAG 186 Query: 212 YSLDMWSLGCMLASMIFRREPF 233 +D+WS G +L M+ R PF Sbjct: 187 PEVDVWSCGIVLYVMLVGRLPF 208 >2YZA-A nrPDB Length = 276 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 96/203 (47%), Gaps = 13/203 (6%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK------KIKREVKILENLRGGT 93 Y L LG G + +V + +V VKIL K + KIKRE++ L+ R Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH-P 71 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYCHS 150 +IIKL + P +V EY++ D+ + + + + R ++L A+DYCH Sbjct: 72 HIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 129 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 ++HRD+KP NV++D ++ D+GL+ + S + PE++ Sbjct: 130 HMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYA 188 Query: 211 DYSLDMWSLGCMLASMIFRREPF 233 +D+WS G +L +++ PF Sbjct: 189 GPEVDIWSCGVILYALLCGTLPF 211 >4FG9-A nrPDB Length = 320 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 69/310 (22%), Positives = 139/310 (44%), Gaps = 57/310 (18%) Query: 32 PSWGNQDD----YQLVRKLGRGKYSEVFEAINITNNERVVVKILK----PVKKKKIKREV 83 P W +D Y LG G +SEV A + + V +K + K+ ++ E+ Sbjct: 8 PRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEI 67 Query: 84 KILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQ--ILTDFDIRFYMYE 140 +L ++ NI+ L D + L+ + ++ + F ++ + T+ D +++ Sbjct: 68 AVLHKIKH-PNIVALDDIYES--GGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQ 124 Query: 141 LLKALDYCHSKGIMHRDVKPHNVM---IDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY 197 +L A+ Y H GI+HRD+KP N++ +D + K+ + D+GL++ P + + Sbjct: 125 VLDAVKYLHDLGIVHRDLKPENLLYYSLD-EDSKIMISDFGLSKMEDPGSVLSTACGTPG 183 Query: 198 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDN--YDQLVRIAKVLGTEEL 255 + PE+L + Y ++D WS+G + ++ PF+ D ++Q+++ Sbjct: 184 YVAPEVLAQ-KPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILK---------- 232 Query: 256 YGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT 315 +Y D P+++DI S A D + L+ D ++R T Sbjct: 233 ----AEYEFD-SPYWDDI---------------------SDSAKDFIRHLMEKDPEKRFT 266 Query: 316 AKEAMEHPYF 325 ++A++HP+ Sbjct: 267 CEQALQHPWI 276 >5J5T-A nrPDB Length = 370 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 48/211 (22%), Positives = 107/211 (50%), Gaps = 17/211 (8%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK---IKREVKILENLRG 91 G+Q+D++L++++G G Y +V++A N+ E +K++K + +++E+ ++++ + Sbjct: 1 GSQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCK- 59 Query: 92 GTNIIKLIDTV--KDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALD 146 NI+ + +D + + E+ + +Y + L++ I + E L+ L Sbjct: 60 HPNIVAYFGSYLRRDKL----WICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 115 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELLV 205 Y HSKG MHRD+K N+++ ++L D+G+ A+ + + + Y+ PE+ Sbjct: 116 YLHSKGKMHRDIKGANILLT-DNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAA 174 Query: 206 DYQMYDYS--LDMWSLGCMLASMIFRREPFF 234 + Y+ D+W++G + + P F Sbjct: 175 VERKGGYNQLCDLWAVGITAIELAELQPPMF 205 >3FXW-A nrPDB Length = 336 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 78/298 (26%), Positives = 134/298 (44%), Gaps = 44/298 (14%) Query: 38 DDYQLVRK-LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNII 96 DDYQL ++ LG G +V E + ++ +K+L K ++EV GG +I+ Sbjct: 28 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL--YDSPKARQEVDHHWQASGGPHIV 85 Query: 97 KLIDTVKDP--VSKTPALVFEYINNTD-FKQLY----QILTDFDIRFYMYELLKALDYCH 149 ++D ++ + ++ E + + F ++ Q T+ + M ++ A+ + H Sbjct: 86 CILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLH 145 Query: 150 SKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 S I HRDVKP N++ ++K L+L D+G A+ + Y+ PE+L Sbjct: 146 SHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK-ETTQNALQTPCYTPYYVAPEVL-GP 203 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 + YD S DMWSLG ++ ++ PF+ N Q + G ++ Sbjct: 204 EKYDKSCDMWSLGVIMYILLCGFPPFY---SNTGQAISP----------GMKRRIR---- 246 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 LGQ+ + N SE VS +A L+ LL+ D +RLT + M HP+ Sbjct: 247 ------LGQYG---FPNPEWSE----VSEDAKQLIRLLLKTDPTERLTITQFMNHPWI 291 >4AF3-A nrPDB Length = 292 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 71/279 (25%), Positives = 137/279 (49%), Gaps = 30/279 (10%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENLRG 91 DD+++ R LG+GK+ V+ A ++ V +K+L K + +++RE++I +L Sbjct: 23 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 82 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYELLKALDYC 148 NI++L + D + L+ EY + + Q FD M EL AL YC Sbjct: 83 -PNILRLYNYFYD--RRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC 139 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQ 208 H K ++HRD+KP N+++ + +L++ D+G + + P+ + + PE +++ + Sbjct: 140 HGKKVIHRDIKPENLLLG-LKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPE-MIEGR 196 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDN--YDQLVRI-----AKV-LGTEELYGYLK 260 M++ +D+W +G + ++ PF N Y ++V++ A V G ++L L Sbjct: 197 MHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLL 256 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEAL 299 ++ +P L Q S W + + +R ++ P AL Sbjct: 257 RH----NPSERLPLAQVSAHPW---VRANSRRVLPPSAL 288 >3LM0-A nrPDB Length = 327 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 51/218 (23%), Positives = 113/218 (51%), Gaps = 16/218 (7%) Query: 44 RKLGRGKYSEVFEAINITNNERVVVKILKPVKK-----KKIKREVKILENLRGGTNIIKL 98 ++LGRGK++ V + I+ + + K LK ++ +I E+ +LE + +I L Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 94 Query: 99 IDTVKDPVSKTPALVFEY-----INNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGI 153 + ++ + L+ EY I + +L +++++ D+ + ++L+ + Y H I Sbjct: 95 HEVYEN--TSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNI 152 Query: 154 MHRDVKPHNVMID--HQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYD 211 +H D+KP N+++ + ++++D+G++ A E + + + PE+L +Y Sbjct: 153 VHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEIL-NYDPIT 211 Query: 212 YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKV 249 + DMW++G ++A M+ F G+DN + + I++V Sbjct: 212 TATDMWNIG-IIAYMLLTHTSPFVGEDNQETYLNISQV 248 >3GUB-A nrPDB Length = 295 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 74/318 (23%), Positives = 141/318 (44%), Gaps = 54/318 (16%) Query: 36 NQDDY-QLVRKLGRGKYSEVFEAINITNNERVVVKILKP---------VKKKKIKREVKI 85 N DDY +LG G+++ V + + + K +K V ++ I+REV I Sbjct: 8 NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSI 67 Query: 86 LENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELL 142 L+ ++ N+I L + ++ L+ E + DF + LT+ + ++ ++L Sbjct: 68 LKEIQH-PNVITLHEVYENKTDVI--LIGELVAGGELFDFLAEKESLTEEEATEFLKQIL 124 Query: 143 KALDYCHSKGIMHRDVKPHNVMI---DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK 199 + Y HS I H D+KP N+M+ + + ++++ID+GLA E+ + F Sbjct: 125 NGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFV 184 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE +V+Y+ DMWS+G + ++ PF G + L ++ V Sbjct: 185 APE-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANVSAV---------- 232 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 Y + D +F++ S A D + +LL D ++R+T +++ Sbjct: 233 -NYEFE-DEYFSN---------------------TSALAKDFIRRLLVKDPKKRMTIQDS 269 Query: 320 MEHPYFYPVVKEQSQPCA 337 ++HP+ P +Q+ A Sbjct: 270 LQHPWIKPKDTQQALSSA 287 >2XNP-A nrPDB Length = 279 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 101/215 (46%), Gaps = 23/215 (10%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREVKILENLRGG 92 +DY+++ +G G Y + ++ + +V K L +K+ + EV +L L+ Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH- 64 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILT--------DFDIRFYMYELLKA 144 NI++ D + D + T +V EY D + T +F +R M +L A Sbjct: 65 PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRV-MTQLTLA 123 Query: 145 LDYCHSKG-----IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY-HPAQEYNVRVASRYF 198 L CH + ++HRD+KP NV +D +Q ++L D+GLA H V + Y+ Sbjct: 124 LKECHRRSDGGHTVLHRDLKPANVFLDGKQ-NVKLGDFGLARILNHDTSFAKTFVGTPYY 182 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 PE + + Y+ D+WSLGC+L + PF Sbjct: 183 MSPEQM-NRMSYNEKSDIWSLGCLLYELCALMPPF 216 >2JDO-A nrPDB Length = 342 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 77/311 (24%), Positives = 131/311 (42%), Gaps = 64/311 (20%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKKIKREV---KILENL 89 +D+ ++ LG+G + +V +KIL+ + K ++ V ++L+N Sbjct: 8 TMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNT 67 Query: 90 RGG-TNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQ--ILTDFDIRFYMYELLKAL 145 R +K D + V EY N + F L + + T+ RFY E++ AL Sbjct: 68 RHPFLTALKYAFQTHDRL----CFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 123 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELL 204 +Y HS+ +++RD+K N+M+D + +++ D+GL E + + PE+L Sbjct: 124 EYLHSRDVVYRDIKLENLMLD-KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVL 182 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 D Y ++D W LG ++ M+ R PF++ Sbjct: 183 EDND-YGRAVDWWGLGVVMYEMMCGRLPFYN----------------------------- 212 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENR--HLVSPEALDLLDKLLRYDHQQRLT-----AK 317 Q + +E + E R +SPEA LL LL+ D +QRL AK Sbjct: 213 -----------QDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAK 261 Query: 318 EAMEHPYFYPV 328 E MEH +F + Sbjct: 262 EVMEHRFFLSI 272 >3ZUT-A nrPDB Length = 362 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 68/301 (22%), Positives = 134/301 (44%), Gaps = 41/301 (13%) Query: 31 VPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILEN 88 +P + D Y+LV+ +G G + + +NE V VK ++ +K + +KRE+ + Sbjct: 12 LPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRS 71 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQI--LTDFDIRFYMYELLKAL 145 LR NI++ + + P A+V EY + + F+++ ++ + RF+ +L+ + Sbjct: 72 LRH-PNIVRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQ-QKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL 204 YCH+ + HRD+K N ++D +L++ +G ++ + V + + PE+L Sbjct: 129 SYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVL 188 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 + + D+WS G L M+ PF +D EE + K H Sbjct: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPF---ED-------------PEEPKNFRKTIHR 232 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 L+ + +++H +SPE L+ ++ D +R++ E H + Sbjct: 233 ILNVQY----------AIPDYVH------ISPECRHLISRIFVADPAKRISIPEIRNHEW 276 Query: 325 F 325 F Sbjct: 277 F 277 >2JC6-A nrPDB Length = 334 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 72/309 (23%), Positives = 137/309 (44%), Gaps = 56/309 (18%) Query: 33 SWGNQDD-----YQLVRKLGRGKYSEVFEAINITNNERVVVKIL--KPVKKKK--IKREV 83 SW Q + ++ LG G +SEV A + VK + K +K K+ I+ E+ Sbjct: 12 SWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEI 71 Query: 84 KILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQ--ILTDFDIRFYMYE 140 +L ++ NI+ L D + P LV + ++ + F ++ + T+ D + + Sbjct: 72 AVLRKIKH-ENIVALEDIYESP--NHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQ 128 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQ--QKKLRLIDWGLAEFYHPAQEYNVRVASRYF 198 +L A+ Y H GI+HRD+KP N++ Q + K+ + D+GL++ + + + Sbjct: 129 VLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGY 188 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDN--YDQLVRIAKVLGTEELY 256 PE+L + Y ++D WS+G + ++ PF+ D+ ++Q+++ Sbjct: 189 VAPEVLAQ-KPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILK----------- 236 Query: 257 GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA 316 +Y D P+++DI S A D + L+ D +R T Sbjct: 237 ---AEYEFD-SPYWDDI---------------------SDSAKDFIRNLMEKDPNKRYTC 271 Query: 317 KEAMEHPYF 325 ++A HP+ Sbjct: 272 EQAARHPWI 280 >3Q53-A nrPDB Length = 306 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 66/292 (22%), Positives = 126/292 (43%), Gaps = 46/292 (15%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVK---ILKPVKKKKIKREVKILENLRGGTNII 96 Y K+G+G V+ A+++ + V ++ + + KK+ I E+ ++ + NI+ Sbjct: 23 YTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKN-PNIV 81 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDYCHSKGIM 154 +D+ V +V EY+ + + + I E L+AL++ HS ++ Sbjct: 82 NYLDSYL--VGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVI 139 Query: 155 HRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNVRVASRYFKGPELLVDYQMYDYS 213 HRD+K N+++ ++L D+G P Q + + V + Y+ PE +V + Y Sbjct: 140 HRDIKSDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPE-VVTRKAYGPK 197 Query: 214 LDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDI 273 +D+WSLG M MI P+ + +N + + + GT EL Sbjct: 198 VDIWSLGIMAIEMIEGEPPYLN--ENPLRALYLIATNGTPEL------------------ 237 Query: 274 LGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 +N +S D L++ L D ++R +AKE ++H + Sbjct: 238 ---------------QNPEKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFL 274 >4REW-A nrPDB Length = 540 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 94/203 (46%), Gaps = 13/203 (6%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK------KIKREVKILENLRGGT 93 Y L LG G + +V + +V VKIL K + KI+RE++ L+ R Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH-P 66 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYCHS 150 +IIKL + P +V EY++ D+ L + + R ++L +DYCH Sbjct: 67 HIIKLYQVISTP--SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 124 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 ++HRD+KP NV++D ++ D+GL+ + S + PE++ Sbjct: 125 HMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 183 Query: 211 DYSLDMWSLGCMLASMIFRREPF 233 +D+WS G +L +++ PF Sbjct: 184 GPEVDIWSSGVILYALLCGTLPF 206 >3TXO-A nrPDB Length = 353 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 98/206 (47%), Gaps = 14/206 (6%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKKIK---REVKILENLRG 91 D+++ +R LG+G + +V A + VK+LK ++ ++ E +IL R Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYELLKALDYC 148 + +L + P V E++N D Q FD RFY E++ AL + Sbjct: 83 HPFLTQLFCCFQTP--DRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFL 140 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDY 207 H KGI++RD+K NV++DH + +L D+G+ E + + PE+L + Sbjct: 141 HDKGIIYRDLKLDNVLLDH-EGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE- 198 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPF 233 +Y ++D W++G +L M+ PF Sbjct: 199 MLYGPAVDWWAMGVLLYEMLCGHAPF 224 >4FIE-A nrPDB Length = 423 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 92/217 (42%), Gaps = 40/217 (18%) Query: 112 LVFEYINNTDFKQL--YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ 169 +V E++ + + + + I +L+AL H++G++HRD+K ++++ H Sbjct: 225 VVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTH-D 283 Query: 170 KKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 228 +++L D+G A+ V + Y+ PEL+ Y +D+WSLG M+ M+ Sbjct: 284 GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLP-YGPEVDIWSLGIMVIEMVD 342 Query: 229 RREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHS 288 P+F+ E +K +L P Sbjct: 343 GEPPYFN-----------------EPPLKAMKMIRDNLPPRL------------------ 367 Query: 289 ENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 +N H VSP LD+LL D QR TA E ++HP+ Sbjct: 368 KNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 404 >3UC3-A nrPDB Length = 361 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 71/305 (23%), Positives = 127/305 (41%), Gaps = 49/305 (16%) Query: 31 VPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILEN 88 +P + D Y V+ +G G + + E V VK ++ + ++RE+ + Sbjct: 13 MPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHRS 72 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDF------DIRFYMYELL 142 LR NI++ + + P A++ EY + +LY+ + + + RF+ +LL Sbjct: 73 LRH-PNIVRFKEVILTPTHL--AIIMEYASG---GELYERICNAGRFSEDEARFFFQQLL 126 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQ-QKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 + YCHS I HRD+K N ++D +L++ D+G ++ + V + + P Sbjct: 127 SGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAP 186 Query: 202 ELLVDYQMYDYSL-DMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK 260 E+L+ Q YD + D+WS G L M+ PF ++ D I ++L Sbjct: 187 EVLL-RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSV-------- 237 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 320 KY I D +SPE L+ ++ D R++ E Sbjct: 238 KYSIPDDIR------------------------ISPECCHLISRIFVADPATRISIPEIK 273 Query: 321 EHPYF 325 H +F Sbjct: 274 THSWF 278 >3ORP-A nrPDB Length = 311 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 98/212 (46%), Gaps = 18/212 (8%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVKILENLR 90 D Y+L LG G SEV A ++ ++ V VK+L+ P + +RE + L Sbjct: 11 SDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALN 70 Query: 91 GGTNIIKLIDT--VKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKAL 145 I+ + DT + P P +V EY++ + + +T + + +AL Sbjct: 71 H-PAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQAL 129 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG----LAEFYHPAQEYNVRVASRYFKGP 201 ++ H GI+HRDVKP N+MI ++++D+G +A+ + + + + + P Sbjct: 130 NFSHQNGIIHRDVKPANIMIS-ATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSP 188 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 E D D++SLGC+L ++ PF Sbjct: 189 E-QARGDSVDARSDVYSLGCVLYEVLTGEPPF 219 >3LLT-A nrPDB Length = 360 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 61/234 (26%), Positives = 108/234 (46%), Gaps = 48/234 (20%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILENLRGGTN 94 + + ++RK+G G + V +I N + VK+++ +KK + K E IL+ ++ Sbjct: 34 NNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDI 93 Query: 95 IIKLIDTV--KDPVSKTPALVFEYINNTDFKQLYQILTDF--------DIRFYMYELLKA 144 I K L+FE + + LY+I+T DI+ Y E+LKA Sbjct: 94 NNNNIVKYHGKFMYYDHMCLIFEPLGPS----LYEIITRNNYNGFHIEDIKLYCIEILKA 149 Query: 145 LDYCHSKGIMHRDVKPHNVMID------------------------HQQKKLRLIDWGLA 180 L+Y + H D+KP N+++D + ++LID+G A Sbjct: 150 LNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCA 209 Query: 181 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLA-----SMIFR 229 F + + + +R ++ PE++++ +D S DMWS GC+LA S++FR Sbjct: 210 TF--KSDYHGSIINTRQYRAPEVILNLG-WDVSSDMWSFGCVLAELYTGSLLFR 260 >6BDL-A nrPDB Length = 347 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 107/209 (51%), Gaps = 23/209 (11%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNER--VVVKILK------PVKKKKIKREVKILENLR 90 D+ ++ LG G + V E + + + E +KILK +++ I+ E +I++ Sbjct: 35 DFNIIDTLGVGGFGRV-ELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAH 93 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL------TDFDIRFYMYELLKA 144 I++L T KD SK ++ E +L+ IL D RFY +++A Sbjct: 94 SDF-IVRLYRTFKD--SKYLYMLMEACLGG---ELWTILRDRGSFEDSTTRFYTACVVEA 147 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL 204 Y HSKGI++RD+KP N+++DH+ +L+D+G A+ ++ + + PE++ Sbjct: 148 FAYLHSKGIIYRDLKPENLILDHRGYA-KLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII 206 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPF 233 ++ + +D S D WSLG ++ ++ PF Sbjct: 207 LN-KGHDISADYWSLGILMYELLTGSPPF 234 >3HDN-A nrPDB Length = 373 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 77/300 (25%), Positives = 125/300 (41%), Gaps = 70/300 (23%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL--KPVKKKKIKREVKILENLRGGTNI 95 D+ ++ +G+G + +V A + VK+L K + KKK ++ + N+ Sbjct: 38 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNV------ 91 Query: 96 IKLIDTVKDP----------VSKTPALVFEYINNTDF---KQLYQILTDFDIRFYMYELL 142 L+ VK P + V +YIN + Q + + RFY E+ Sbjct: 92 --LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 149 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 202 AL Y HS I++RD+KP N+++D Q + L D+GL + E+N S + PE Sbjct: 150 SALGYLHSLNIVYRDLKPENILLD-SQGHIVLTDFGLCK---ENIEHN-STTSTFCGTPE 204 Query: 203 LL----VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258 L + Q YD ++D W LG +L M++ PF+ T E+Y Sbjct: 205 YLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRN--------------TAEMYDN 250 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE 318 + + L P+ I + RH LL+ LL+ D +RL AK+ Sbjct: 251 ILNKPLQLKPN----------------ITNSARH--------LLEGLLQKDRTKRLGAKD 286 >4JDH-A nrPDB Length = 346 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 92/217 (42%), Gaps = 40/217 (18%) Query: 112 LVFEYINNTDFKQL--YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ 169 +V E++ + + + + I +L+AL H++G++HRD+K ++++ H Sbjct: 148 VVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTH-D 206 Query: 170 KKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 228 +++L D+G A+ V + Y+ PEL+ Y +D+WSLG M+ M+ Sbjct: 207 GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLP-YGPEVDIWSLGIMVIEMVD 265 Query: 229 RREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHS 288 P+F+ E +K +L P Sbjct: 266 GEPPYFN-----------------EPPLKAMKMIRDNLPPRL------------------ 290 Query: 289 ENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 +N H VSP LD+LL D QR TA E ++HP+ Sbjct: 291 KNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 327 >4CFH-A nrPDB Length = 493 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 94/203 (46%), Gaps = 13/203 (6%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK------KIKREVKILENLRGGT 93 Y L LG G + +V + +V VKIL K + KI+RE++ L+ R Sbjct: 35 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH-P 93 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYCHS 150 +IIKL + P +V EY++ D+ L + + R ++L +DYCH Sbjct: 94 HIIKLYQVISTP--SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 151 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 ++HRD+KP NV++D ++ D+GL+ + S + PE++ Sbjct: 152 HMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 210 Query: 211 DYSLDMWSLGCMLASMIFRREPF 233 +D+WS G +L +++ PF Sbjct: 211 GPEVDIWSSGVILYALLCGTLPF 233 >4IAN-A nrPDB Length = 358 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 104/217 (47%), Gaps = 30/217 (13%) Query: 134 IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA-QEYNVR 192 +R Y +L AL I+H D+KP N++++ + L+L D+G A H A + Sbjct: 137 VRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSAS--HVADNDITPY 194 Query: 193 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIA----- 247 + SR+++ PE+++ + YDY +DMWS+GC L + + + F G+ N + ++++A Sbjct: 195 LVSRFYRAPEIIIG-KSYDYGIDMWSVGCTLYEL-YTGKILFPGKTN-NHMLKLAMDLKG 251 Query: 248 KVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHS------------------- 288 K+ G K H D + +F I +R + + S Sbjct: 252 KMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLP 311 Query: 289 ENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 E++ + DLLD++L D +R++ +A++H + Sbjct: 312 EDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFI 348 >2Q0N-A nrPDB Length = 301 Score = 70.5 bits (171), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 50/186 (26%), Positives = 82/186 (44%), Gaps = 38/186 (20%) Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFK 199 +L+AL H++G++HRD+K ++++ H +++L D+G A+ V + Y+ Sbjct: 134 VLQALSVLHAQGVIHRDIKSDSILLTH-DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWM 192 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PEL+ Y +D+WSLG M+ M+ P+F+ E + Sbjct: 193 APELISRLP-YGPEVDIWSLGIMVIEMVDGEPPYFN-----------------EPPLKAM 234 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 K +L P +N H VSP LD+LL D QR TA E Sbjct: 235 KMIRDNLPPRL------------------KNLHKVSPSLKGFLDRLLVRDPAQRATAAEL 276 Query: 320 MEHPYF 325 ++HP+ Sbjct: 277 LKHPFL 282 >4TNB-A nrPDB Length = 590 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 81/311 (26%), Positives = 129/311 (41%), Gaps = 65/311 (20%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR---------EVKIL 86 ++ ++ R LG+G + EV A + ++ K ++KK+IK+ E +IL Sbjct: 182 TKNTFRQYRVLGKGGFGEVC-ACQVRATGKMYA--CKRLEKKRIKKRKGESMALNEKQIL 238 Query: 87 ENLRGG--TNIIKLIDTVKDPVSKTPALVFEYINNTDFK-QLYQI----LTDFDIRFYMY 139 E + N+ +T KD + LV +N D K +Y + + FY Sbjct: 239 EKVNSQFVVNLAYAYET-KDAL----CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAA 293 Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK 199 E+L L+ H + ++RD+KP N+++D +R+ D GLA RV + + Sbjct: 294 EILCGLEDLHHENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRVGTVGYM 352 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE+L + Q Y S D W LGC++ MI + PF ++ + +VL TEE+Y Sbjct: 353 APEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYS-- 409 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL----- 314 H S EA + LL D +QRL Sbjct: 410 --------------------------------HKFSEEAKSICKMLLTKDAKQRLGCQEE 437 Query: 315 TAKEAMEHPYF 325 A E HP+F Sbjct: 438 EAAEVKRHPFF 448 >4XBR-A nrPDB Length = 366 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 67/287 (23%), Positives = 124/287 (43%), Gaps = 46/287 (16%) Query: 45 KLGRGKYSEVFEAINITNNERVVVK---ILKPVKKKKIKREVKILENLRGGTNIIKLIDT 101 K+G G V A ++ + V VK + K +++ + EV I+ + + N++++ ++ Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH-ENVVEMYNS 159 Query: 102 VKDPVSKTPALVFEYINNTDFKQL--YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVK 159 V +V E++ + + + + I +L+AL H++G++HRD+K Sbjct: 160 YL--VGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 217 Query: 160 PHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 218 ++++ H +++L D+G A+ V + Y+ PEL+ Y +D+WS Sbjct: 218 SDSILLTH-DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLP-YGPEVDIWS 275 Query: 219 LGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHS 278 LG M+ M+ P+F+ E +K +L P Sbjct: 276 LGIMVIEMVDGEPPYFN-----------------EPPLKAMKMIRDNLPPRL-------- 310 Query: 279 RKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 +N H VSP LD+LL D QR TA E ++HP+ Sbjct: 311 ----------KNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 347 >3UDB-A nrPDB Length = 317 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 68/301 (22%), Positives = 133/301 (44%), Gaps = 41/301 (13%) Query: 31 VPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILEN 88 +P + D Y+LV+ +G G + + NE V VK ++ +K + +KRE+ + Sbjct: 12 LPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREIINHRS 71 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQI--LTDFDIRFYMYELLKAL 145 LR NI++ + + P A+V EY + + F+++ ++ + RF+ +L+ + Sbjct: 72 LRH-PNIVRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 128 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQ-QKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL 204 Y H+ + HRD+K N ++D +L++ D+G ++ + V + + PE+L Sbjct: 129 SYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVL 188 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 + + D+WS G L M+ PF +D EE + K H Sbjct: 189 LKKEYDGKVADVWSCGVTLYVMLVGAYPF---ED-------------PEEPKNFRKTIHR 232 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 L+ + +++H +SPE L+ ++ D +R++ E H + Sbjct: 233 ILNVQY----------AIPDYVH------ISPECRHLISRIFVADPAKRISIPEIRNHEW 276 Query: 325 F 325 F Sbjct: 277 F 277 >2WTK-C nrPDB Length = 305 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 68/244 (27%), Positives = 114/244 (46%), Gaps = 27/244 (11%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILK-------PVKKKKIKREVKILENLRGGTNIIKL 98 LG G Y +V E ++ R VKILK P + +K+E+++L LR N+I+L Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH-KNVIQL 71 Query: 99 IDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCHSKGIM 154 +D + + + +V EY + L + Y +L+ L+Y HS+GI+ Sbjct: 72 VDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIV 131 Query: 155 HRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP-AQEYNVRVA--SRYFKGPELLVDYQMYD 211 H+D+KP N+++ L++ G+AE HP A + R + S F+ PE+ + Sbjct: 132 HKDIKPGNLLLT-TGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFS 190 Query: 212 -YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 + +D+WS G L ++ P F G + Y I K G+ + G D P Sbjct: 191 GFKVDIWSAGVTLYNITTGLYP-FEGDNIYKLFENIGK--GSYAIPG-------DCGPPL 240 Query: 271 NDIL 274 +D+L Sbjct: 241 SDLL 244 >4RED-A nrPDB Length = 351 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 93/203 (45%), Gaps = 13/203 (6%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK------KIKREVKILENLRGGT 93 Y L LG G + +V + V VKIL K + KI+RE++ L+ R Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH-P 74 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYCHS 150 +IIKL + P +V EY++ D+ L + + R ++L +DYCH Sbjct: 75 HIIKLYQVISTP--SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHR 132 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 ++HRD+KP NV++D ++ D+GL+ + S + PE++ Sbjct: 133 HMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 Query: 211 DYSLDMWSLGCMLASMIFRREPF 233 +D+WS G +L +++ PF Sbjct: 192 GPEVDIWSSGVILYALLCGTLPF 214 >3NYO-A nrPDB Length = 576 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/225 (27%), Positives = 96/225 (42%), Gaps = 46/225 (20%) Query: 111 ALVFEYINNTDFK-QLYQI----LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMI 165 LV +N D K +Y + + FY E+ L+ H + I++RD+KP N+++ Sbjct: 260 CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL 319 Query: 166 DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 225 D +R+ D GLA Q RV + + PE+ V + Y +S D W+LGC+L Sbjct: 320 D-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV-VKNERYTFSPDWWALGCLLYE 377 Query: 226 MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENF 285 MI + PF Q ++ R EE+ +K+ Sbjct: 378 MIAGQSPF---QQRKKKIKR-------EEVERLVKE------------------------ 403 Query: 286 IHSENRHLVSPEALDLLDKLLRYDHQQRL-----TAKEAMEHPYF 325 + E SP+A L +LL D +RL +A+E EHP F Sbjct: 404 VPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 >6HXF-B nrPDB Length = 302 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 114/222 (51%), Gaps = 19/222 (8%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTN--IIK 97 +++V +LG G + +V++A N K+++ +++++ + +E L + I+K Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVK 80 Query: 98 LIDT------VKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSK 151 L+ + + P + I +L + LT+ I+ ++L+AL++ HSK Sbjct: 81 LLGAYYHDGKLWIMIEFCPGGAVDAI----MLELDRGLTEPQIQVVCRQMLEALNFLHSK 136 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELLVDYQM- 209 I+HRD+K NV++ + +RL D+G+ A+ Q+ + + + Y+ PE+++ M Sbjct: 137 RIIHRDLKAGNVLMT-LEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 195 Query: 210 ---YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 YDY D+WSLG L M + EP H + L++IAK Sbjct: 196 DTPYDYKADIWSLGITLIEMA-QIEPPHHELNPMRVLLKIAK 236 >3DLS-A nrPDB Length = 335 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 56/220 (25%), Positives = 101/220 (45%), Gaps = 19/220 (8%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKP-----------VKKKKIKREVKILEN 88 Y + LG G + V+ A++ N+ VVVK +K K K+ E+ IL Sbjct: 26 YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSR 85 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEY----INNTDFKQLYQILTDFDIRFYMYELLKA 144 + NIIK++D ++ LV E ++ F + L + + +L+ A Sbjct: 86 VEHA-NIIKVLDIFEN--QGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSA 142 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL 204 + Y K I+HRD+K N++I + ++LID+G A + + + + + PE+L Sbjct: 143 VGYLRLKDIIHRDIKDENIVI-AEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVL 201 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLV 244 + L+MWSLG L +++F PF ++ + + Sbjct: 202 MGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAI 241 >6CQF-A nrPDB Length = 297 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 53/207 (25%), Positives = 102/207 (49%), Gaps = 13/207 (6%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK---KKIKREVKILENLRGGT 93 +D Y L+++LG G Y EVF+A + + + V +K++K +++E+ IL+ R Sbjct: 15 RDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRH-A 73 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYCHS 150 NI+ + + + E+ + +YQ+ L++ I + E+L+ L Y HS Sbjct: 74 NIVAYHGSYL--WLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 131 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPEL--LVDY 207 + +HRD+K N++I+ ++RL D+G+ A+ + + Y+ PE+ + Sbjct: 132 QKKIHRDIKGANILIN-DAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALK 190 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFF 234 Y+ D+WSLG + + P F Sbjct: 191 GGYNELCDIWSLGITAIELAELQPPLF 217 >5KCV-A nrPDB Length = 460 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 81/310 (26%), Positives = 138/310 (44%), Gaps = 63/310 (20%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKKIK---REVKILENLRG 91 ++++ ++ LG+G + +V +KILK V K ++ E ++L+N R Sbjct: 162 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 221 Query: 92 GTNIIKLIDTVKDPVSKTPALVF--EYINNTD-FKQLYQ--ILTDFDIRFYMYELLKALD 146 + +K L F EY N + F L + + ++ RFY E++ ALD Sbjct: 222 -----PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 276 Query: 147 YCHS-KGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELL 204 Y HS K +++RD+K N+M+D + +++ D+GL E + + PE+L Sbjct: 277 YLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 335 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 D Y ++D W LG ++ M+ R PF++ QD+ ++ +++ EE+ Sbjct: 336 EDND-YGRAVDWWGLGVVMYEMMCGRLPFYN-QDHE----KLFELILMEEI--------- 380 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-----AKEA 319 F LG PEA LL LL+ D +QRL AKE Sbjct: 381 ----RFPRTLG--------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKEI 416 Query: 320 MEHPYFYPVV 329 M+H +F +V Sbjct: 417 MQHRFFAGIV 426 >3MV5-A nrPDB Length = 342 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 81/311 (26%), Positives = 138/311 (44%), Gaps = 61/311 (19%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKKIK---REVKILENL 89 ++++ ++ LG+G + +V +KILK V K ++ E ++L+N Sbjct: 8 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 67 Query: 90 RGG-TNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQ--ILTDFDIRFYMYELLKAL 145 R +K D + V EY N + F L + + ++ RFY E++ AL Sbjct: 68 RHPFLTALKYSFQTHDRL----CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 123 Query: 146 DYCHS-KGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPEL 203 DY HS K +++RD+K N+M+D + +++ D+GL E + + PE+ Sbjct: 124 DYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 182 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 L D Y ++D W LG ++ M+ R PF++ QD+ ++ +++ EE+ Sbjct: 183 LEDND-YGRAVDWWGLGVVMYEMMCGRLPFYN-QDHE----KLFELILMEEI-------- 228 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-----AKE 318 F LG PEA LL LL+ D +QRL AKE Sbjct: 229 -----RFPRTLG--------------------PEAKSLLSGLLKKDPKQRLGGGSEDAKE 263 Query: 319 AMEHPYFYPVV 329 M+H +F +V Sbjct: 264 IMQHRFFAGIV 274 >1VZO-A nrPDB Length = 355 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 105/210 (50%), Gaps = 15/210 (7%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIK 97 ++++L++ LG G Y +VF I+ ++ + +K +KK I ++ K E+ R +++ Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 98 LIDTVKDPVSKTPA--------LVFEYINNTD-FKQLYQI--LTDFDIRFYMYELLKALD 146 I V+ A L+ +YIN + F L Q T+ +++ Y+ E++ AL+ Sbjct: 114 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 173 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQE--YNVRVASRYFKGPEL 203 + H GI++RD+K N+++D + L D+GL+ EF E Y+ Y + Sbjct: 174 HLHKLGIIYRDIKLENILLD-SNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDIV 232 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 +D ++D WSLG ++ ++ PF Sbjct: 233 RGGDSGHDKAVDWWSLGVLMYELLTGASPF 262 >5N23-A nrPDB Length = 352 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 57/219 (26%), Positives = 108/219 (49%), Gaps = 13/219 (5%) Query: 27 YEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIKREV 83 +E+ + + D ++ +R LG G + V + +KIL K VK K+I+ + Sbjct: 31 WESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL 90 Query: 84 --KILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQI--LTDFDIRFYM 138 K ++ ++KL + KD + +V EY + F L +I ++ RFY Sbjct: 91 NEKRIQQAVNFPFLVKLEFSFKD--NSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYA 148 Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYF 198 +++ +Y HS +++RD+KP N++ID QQ +++ D+G A+ + + Y Sbjct: 149 AQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIKVADFGFAKRVKGRTPWTLCGTPEYL 207 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQ 237 PE+++ + Y+ ++D W+LG ++ M PFF Q Sbjct: 208 -APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQ 244 >4KS7-A nrPDB Length = 292 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 46/186 (24%), Positives = 86/186 (46%), Gaps = 38/186 (20%) Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFK 199 +L+AL Y H++G++HRD+K ++++ +++L D+G A+ + V + Y+ Sbjct: 128 VLQALAYLHAQGVIHRDIKSDSILLT-LDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWM 186 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE ++ +Y +D+WSLG M+ M+ P+F ++ + Sbjct: 187 APE-VISRSLYATEVDIWSLGIMVIEMVDGEPPYF-----------------SDSPVQAM 228 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 K+ P +N H VSP D L+++L D Q+R TA+E Sbjct: 229 KRLRDSPPPKL------------------KNSHKVSPVLRDFLERMLVRDPQERATAQEL 270 Query: 320 MEHPYF 325 ++HP+ Sbjct: 271 LDHPFL 276 >5FQD-C nrPDB Length = 341 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 51/156 (32%), Positives = 83/156 (53%), Gaps = 20/156 (12%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKI-LKPVKKKKIKREVKILENLRGGTNI--I 96 Y+LVRK+G G + +++ AINITN E V VK+ + + ++ E K+ + L+GG I I Sbjct: 21 YKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHI 80 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMY-------ELLKALDYCH 149 + KD LV + + + + L+ + RF M +++ ++Y H Sbjct: 81 RWYGQEKD----YNVLVMDLLGPS-LEDLFNFCSR---RFTMKTVLMLADQMISRIEYVH 132 Query: 150 SKGIMHRDVKPHNVM--IDHQQKKLRLIDWGLAEFY 183 +K +HRD+KP N + I KL LID+GLA+ Y Sbjct: 133 TKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY 168 >4EQM-A nrPDB Length = 294 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 64/211 (30%), Positives = 102/211 (48%), Gaps = 21/211 (9%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVK--ILKPVKK----KKIKREVKILENLRGGT 93 Y++V KLG G S V+ A + N +V +K + P +K K+ +REV L Sbjct: 13 YKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQL-SHQ 71 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKALDYCH 149 NI+ +ID D LV EYI + + + D I F ++L + + H Sbjct: 72 NIVSMIDV--DEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINF-TNQILDGIKHAH 128 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP---AQEYNVRVASRYFKGPELLVD 206 I+HRD+KP N++ID K L++ D+G+A+ Q +V +YF PE Sbjct: 129 DMRIVHRDIKPQNILID-SNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYF-SPE-QAK 185 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQ 237 + D D++S+G +L M+ EP F+G+ Sbjct: 186 GEATDECTDIYSIGIVLYEMLV-GEPPFNGE 215 >2JAM-A nrPDB Length = 304 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 66/307 (21%), Positives = 133/307 (43%), Gaps = 57/307 (18%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILK---PVKKKKIKREVKILENLRGGTNIIKLIDTV 102 LG G +SEVF + +K +K + ++ E+ +L+ ++ NI+ L D Sbjct: 17 LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKH-ENIVTLEDIY 75 Query: 103 KDPVSKTPALVFEYINNTD-FKQLYQ--ILTDFDIRFYMYELLKALDYCHSKGIMHRDVK 159 + LV + ++ + F ++ + + T+ D + ++L A+ Y H GI+HRD+K Sbjct: 76 ESTTHY--YLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLK 133 Query: 160 PHNV--MIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMW 217 P N+ + + K+ + D+GL++ + + + PE+L + Y ++D W Sbjct: 134 PENLLYLTPEENSKIMITDFGLSKMEQNGI-MSTACGTPGYVAPEVLAQ-KPYSKAVDCW 191 Query: 218 SLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQH 277 S+G + ++ PF+ ++ +L+ +K+ + + + F Sbjct: 192 SIGVITYILLCGYPPFYEETES--------------KLFEKIKEGYYEFESPF------- 230 Query: 278 SRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY----------FYP 327 W++ +S A D + LL D +R T ++A+ HP+ YP Sbjct: 231 ----WDD---------ISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYP 277 Query: 328 VVKEQSQ 334 V Q Q Sbjct: 278 SVSLQIQ 284 >6E9W-A nrPDB Length = 443 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 104/216 (48%), Gaps = 29/216 (13%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR-------EVKILENLR 90 +DY++V+ +GRG + EV + + + +K+L K + IKR E + + Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLS--KFEMIKRSDSAFFWEERDIMAFA 159 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI-----RFYMYELLKAL 145 +++L +D + +V EY+ D L +++++D+ RFY E++ AL Sbjct: 160 NSPWVVQLFYAFQD--DRYLYMVMEYMPGGD---LVNLMSNYDVPEKWARFYTAEVVLAL 214 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR----VASRYFKGP 201 D HS G +HRDVKP N+++D + L+L D+G +E VR V + + P Sbjct: 215 DAIHSMGFIHRDVKPDNMLLD-KSGHLKLADFGTC--MKMNKEGMVRCDTAVGTPDYISP 271 Query: 202 ELLVDY---QMYDYSLDMWSLGCMLASMIFRREPFF 234 E+L Y D WS+G L M+ PF+ Sbjct: 272 EVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFY 307 >5DYK-A nrPDB Length = 853 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 113/218 (51%), Gaps = 24/218 (11%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVK-ILKPVKKKKI-----KREVKILENLRG 91 D+ + R +GRG F + + +++ ++ LK V K+ I + +K+ + Sbjct: 539 DELETERIIGRG----TFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITA 594 Query: 92 GTN---IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKAL 145 + II+L+ T KD SK + E + + + +L+ +FY+ ++ A+ Sbjct: 595 ENDHPFIIRLVRTFKD--SKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAI 652 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV 205 +Y H + I++RD+KP N+++D +Q ++LID+G A+ + Y + V + ++ PE+++ Sbjct: 653 EYLHERNIVYRDLKPENILLD-KQGYVKLIDFGCAKKVQ-GRAYTL-VGTPHYMAPEVIL 709 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQL 243 + Y ++D+W+LG L I PF G D DQL Sbjct: 710 G-KGYGCTVDIWALGICLYEFICGPLPF--GNDEEDQL 744 >6DBM-A nrPDB Length = 318 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 60/226 (26%), Positives = 106/226 (46%), Gaps = 29/226 (12%) Query: 43 VRKLGRGKYSEV----FEAINITNNERVVVKILK----PVKKKKIKREVKILENLRGGTN 94 +R LG G + +V ++ N E V VK LK P + K+E+ IL L + Sbjct: 36 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYH-EH 94 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQ--------LYQILTDFDIRFYMYELLKALD 146 IIK +D + + LV EY+ + L Q+L + ++ + + Sbjct: 95 IIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLL------LFAQQICEGMA 148 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-YNVRV---ASRYFKGPE 202 Y HS+ +HRD+ NV++D+ + +++ D+GLA+ E Y VR + ++ PE Sbjct: 149 YLHSQHYIHRDLAARNVLLDN-DRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPE 207 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 L +Y+ Y Y+ D+WS G L ++ + + +L+ IA+ Sbjct: 208 CLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQ 252 >3M42-A nrPDB Length = 299 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 76/317 (23%), Positives = 134/317 (42%), Gaps = 68/317 (21%) Query: 38 DDYQLVRK-LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNII 96 DDY++ + LG G +V + N E+ +K+L+ K + REV++ +I+ Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--REVELHWRASQCPHIV 74 Query: 97 KLIDTVKDPVS--KTPALVFEYINNTD-FKQLY----QILTDFDIRFYMYELLKALDYCH 149 +++D ++ + K +V E ++ + F ++ Q T+ + M + +A+ Y H Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 150 SKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 S I HRDVKP N++ ++ L+L D+G A+ Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE----------------------TTG 172 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFF--HGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 + YD S DMWSLG ++ ++ PF+ HG + I+ + T G +Y Sbjct: 173 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHG-------LAISPGMKTRIRMG---QYEFP 222 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 +P +++ VS E L+ LL+ + QR+T E M HP+ Sbjct: 223 -NPEWSE---------------------VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 260 Query: 326 YPVVKEQSQPCADNAVL 342 K P + VL Sbjct: 261 MQSTKVPQTPLHTSRVL 277 >3QA8-A nrPDB Length = 676 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/212 (26%), Positives = 99/212 (46%), Gaps = 20/212 (9%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKI----LKPVKKKKIKREVKILENLRGGTNI 95 +++ +LG G + V I+ E+V +K L P +++ E++I++ L N+ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKL-NHPNV 74 Query: 96 IKLIDTVKDPVSKT-----PALVFEYINNTDFKQ-LYQI-----LTDFDIRFYMYELLKA 144 + + V D + K P L EY D ++ L Q L + IR + ++ A Sbjct: 75 VSARE-VPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSA 133 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKKL--RLIDWGLAEFYHPAQEYNVRVASRYFKGPE 202 L Y H I+HRD+KP N+++ ++L ++ID G A+ + V + + PE Sbjct: 134 LRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPE 193 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFF 234 LL + + Y ++D WS G + I PF Sbjct: 194 LL-EQKKYTVTVDYWSFGTLAFECITGFRPFL 224 >1ZXE-A nrPDB Length = 303 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 60/271 (22%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRGG---- 92 D++ + LG+G + +V +A N ++ +K ++ ++K I EV +L +L Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVVR 66 Query: 93 --------TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI--------RF 136 N +K + VK T + EY N + LY ++ ++ R Sbjct: 67 YYAAWLERRNFVKPMTAVKK--KSTLFIQMEYCEN---RTLYDLIHSENLNQQRDEYWRL 121 Query: 137 YMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH------------ 184 + ++L+AL Y HS+GI+HR++KP N+ ID + + +++ D+GLA+ H Sbjct: 122 FR-QILEALSYIHSQGIIHRNLKPMNIFID-ESRNVKIGDFGLAKNVHRSLDILKLDSQN 179 Query: 185 -PAQEYNVR--VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYD 241 P N+ + + + E+L Y+ +DM+SLG + MI+ PF G + + Sbjct: 180 LPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGMERVN 236 Query: 242 QLVRIAKVLGTEELYGYLKKYHIDLDPHFND 272 L + L+ I+ P F+D Sbjct: 237 ILKK-------------LRSVSIEFPPDFDD 254 >4WB7-A nrPDB Length = 405 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/220 (26%), Positives = 112/220 (50%), Gaps = 16/220 (7%) Query: 27 YEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIK--- 80 +E+ + + D ++ ++ LG G + V + +KIL K VK K+I+ Sbjct: 85 WESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL 144 Query: 81 REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQI--LTDFDIRFY 137 E +IL+ + ++KL + KD + +V EY+ + F L +I ++ RFY Sbjct: 145 NEKRILQAV-NFPFLVKLEFSFKD--NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFY 201 Query: 138 MYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY 197 +++ +Y HS +++RD+KP N++ID QQ +++ D+G A+ + + + Y Sbjct: 202 AAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRVK-GRTWTLCGTPEY 259 Query: 198 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQ 237 PE+++ + Y+ ++D W+LG ++ M PFF Q Sbjct: 260 L-APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQ 297 >6ED6-A nrPDB Length = 415 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 101/214 (47%), Gaps = 25/214 (11%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR-------EVKILENLR 90 +DY +V+ +GRG + EV + + + +K+L K + IKR E + + Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLS--KFEMIKRSDSAFFWEERDIMAFA 145 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI-----RFYMYELLKAL 145 +++L +D + +V EY+ D L +++++D+ +FY E++ AL Sbjct: 146 NSPWVVQLFYAFQD--DRYLYMVMEYMPGGD---LVNLMSNYDVPEKWAKFYTAEVVLAL 200 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ--EYNVRVASRYFKGPEL 203 D HS G++HRDVKP N+++D + L+L D+G + V + + PE+ Sbjct: 201 DAIHSMGLIHRDVKPDNMLLD-KHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEV 259 Query: 204 LVDY---QMYDYSLDMWSLGCMLASMIFRREPFF 234 L Y D WS+G L M+ PF+ Sbjct: 260 LKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFY 293 >6CCF-A nrPDB Length = 290 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 39/163 (23%), Positives = 84/163 (51%), Gaps = 7/163 (4%) Query: 77 KKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--QILTDFDI 134 +++ +E+ IL+ L N++KLI+ + DP LVF+ + ++ + ++ Sbjct: 73 ERVYQEIAILKKLDH-VNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQA 131 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRV 193 R Y+ +++ L+Y H + I+HRD+KP N+++ +++ D+G++ +F + + Sbjct: 132 RLYLRDVILGLEYLHCQKIVHRDIKPSNLLLG-DDGHVKIADFGVSNQFEGNDAQLSSTA 190 Query: 194 ASRYFKGPELLVDY--QMYDYSLDMWSLGCMLASMIFRREPFF 234 + F PE + D +LD+W+ G L ++ + PF Sbjct: 191 GTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFI 233 >4OLI-A nrPDB Length = 645 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 60/226 (26%), Positives = 106/226 (46%), Gaps = 29/226 (12%) Query: 43 VRKLGRGKYSEV----FEAINITNNERVVVKILK----PVKKKKIKREVKILENLRGGTN 94 +R LG G + +V ++ N E V VK LK P + K+E+ IL L + Sbjct: 358 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYH-EH 416 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQ--------LYQILTDFDIRFYMYELLKALD 146 IIK +D K+ LV EY+ + L Q+L + ++ + + Sbjct: 417 IIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLL------LFAQQICEGMA 470 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-YNVRV---ASRYFKGPE 202 Y HS+ +HR++ NV++D+ + +++ D+GLA+ E Y VR + ++ PE Sbjct: 471 YLHSQHYIHRNLAARNVLLDN-DRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPE 529 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 L +Y+ Y Y+ D+WS G L ++ + + +L+ IA+ Sbjct: 530 CLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQ 574 >5D7A-A nrPDB Length = 308 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 48/213 (22%), Positives = 97/213 (45%), Gaps = 23/213 (10%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV--KKKKIKREVKILENLRGGTNIIK 97 ++LV +G G Y +V++ ++ + +K++ ++++IK+E+ +L+ NI Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 78 Query: 98 LIDTVKDPVSKTPA-------LVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKAL 145 + K P LV E+ L + L + I + E+L+ L Sbjct: 79 YYGAF---IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGL 135 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELL 204 + H ++HRD+K NV++ + +++L+D+G+ A+ N + + Y+ PE++ Sbjct: 136 SHLHQHKVIHRDIKGQNVLLT-ENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 194 Query: 205 VDYQ----MYDYSLDMWSLGCMLASMIFRREPF 233 + YD+ D+WSLG M P Sbjct: 195 ACDENPDATYDFKSDLWSLGITAIEMAEGAPPL 227 >5LOH-A nrPDB Length = 341 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 65/246 (26%), Positives = 116/246 (47%), Gaps = 27/246 (10%) Query: 4 PAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNN 63 P AGS+ E + E VP + +++ +V+ + RG + +V+ + Sbjct: 6 PTAGSKK----EPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVY--LGQKGG 59 Query: 64 ERVVVKILKPVK--KKKIKREVKILEN---LRGGTNIIKLIDTVKDPVSKTPALVFEYIN 118 + VK++K K + +V+ + L I+ L +++ + LV EY+ Sbjct: 60 KLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQS--ANNVYLVMEYLI 117 Query: 119 NTDFKQLYQILTDFDIRF---YMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLI 175 D K L I FD Y+ E+ ALDY H GI+HRD+KP N++I + + ++L Sbjct: 118 GGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISN-EGHIKLT 176 Query: 176 DWGLAEFYHPAQEYNVR--VASRYFKG------PELLVDYQMYDYSLDMWSLGCMLASMI 227 D+GL++ ++ N+ + +R F G PELL+ + + ++D W+LG L + Sbjct: 177 DFGLSKVTL-NRDINMMDILTTRTFCGTPDYLAPELLLG-RAHGPAVDWWALGVCLFEFL 234 Query: 228 FRREPF 233 PF Sbjct: 235 TGIPPF 240 >4QMW-A nrPDB Length = 310 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 98/200 (49%), Gaps = 13/200 (6%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKIL----KPVKKKKIKREVKILENLRGGTNI 95 + + K+G+G + EVF+ I+ + V +KI+ + + I++E+ +L Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 90 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI--LTDFDIRFYMYELLKALDYCHSKGI 153 +KD ++ EY+ L + L + I + E+LK LDY HS+ Sbjct: 91 KYYGSYLKD---TKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKK 147 Query: 154 MHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNVRVASRYFKGPELLVDYQMYDY 212 +HRD+K NV++ + +++L D+G+A Q + N V + ++ PE ++ YD Sbjct: 148 IHRDIKAANVLLS-EHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE-VIKQSAYDS 205 Query: 213 SLDMWSLGCMLASMIFRREP 232 D+WSLG + A + R EP Sbjct: 206 KADIWSLG-ITAIELARGEP 224 >2XIK-A nrPDB Length = 294 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 61/218 (27%), Positives = 106/218 (48%), Gaps = 20/218 (9%) Query: 29 AHVPSWGNQ----DDYQLVRKL---GRGKYSEVFEAINITNNERVVVKIL----KPVKKK 77 AH+ + NQ D +L KL G+G + EV++ I+ E V +KI+ + + Sbjct: 3 AHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIE 62 Query: 78 KIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI--LTDFDIR 135 I++E+ +L +K S ++ EY+ L + L + I Sbjct: 63 DIQQEITVLSQCDSPYITRYFGSYLK---STKLWIIMEYLGGGSALDLLKPGPLEETYIA 119 Query: 136 FYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNVRVA 194 + E+LK LDY HS+ +HRD+K NV++ +Q ++L D+G+A Q + N V Sbjct: 120 TILREILKGLDYLHSERKIHRDIKAANVLLS-EQGDVKLADFGVAGQLTDTQIKRNTFVG 178 Query: 195 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREP 232 + ++ PE ++ YD+ D+WSLG + A + + EP Sbjct: 179 TPFWMAPE-VIKQSAYDFKADIWSLG-ITAIELAKGEP 214 >5FET-A nrPDB Length = 847 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 46/152 (30%), Positives = 84/152 (55%), Gaps = 11/152 (7%) Query: 95 IIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYCHSK 151 II+L+ T KD S + E + D + +L+ +FY+ ++ A++Y H + Sbjct: 595 IIRLVRTFKD--SNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHER 652 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYD 211 I++RD+KP N+++D +Q ++LID+G A+ + Y + V + ++ PE+++ + Y Sbjct: 653 NIVYRDLKPENILLD-KQGYVKLIDFGCAKKIQ-GRAYTL-VGTPHYMAPEVILG-KGYG 708 Query: 212 YSLDMWSLGCMLASMIFRREPFFHGQDNYDQL 243 ++D+W+LG L I PF G D DQL Sbjct: 709 CTVDIWALGVCLYEFICGPLPF--GNDQEDQL 738 >5X3F-B nrPDB Length = 393 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 107/209 (51%), Gaps = 16/209 (7%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIK---REVKILENLRG 91 D + ++ LG G + V + + +KIL K VK K+I+ E +IL+ + Sbjct: 84 DQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 143 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQI--LTDFDIRFYMYELLKALDYC 148 ++KL + KD + +V EY+ + F L +I ++ RFY +++ +Y Sbjct: 144 PF-LVKLEFSFKD--NSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 200 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQ 208 HS +++RD+KP N++ID QQ +++ D+G A+ + + + Y PE+++ + Sbjct: 201 HSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRVK-GRTWTLCGTPEYL-APEIILS-K 256 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQ 237 Y+ ++D W+LG ++ M PFF Q Sbjct: 257 GYNKAVDWWALGVLIYEMAAGYPPFFADQ 285 >3IS5-A nrPDB Length = 285 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 67/305 (21%), Positives = 134/305 (43%), Gaps = 54/305 (17%) Query: 35 GNQDD-YQLVRKLGRGKYSEVFEAINITNN-ERVVVKILK---PVKKKKIKREVKILENL 89 G DD + RKLG G + +V ++ ERV+ I K V ++I+ E+++L++L Sbjct: 18 GTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSL 77 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-------QILTDFDIRFYMYELL 142 NIIK+ + +D +V E + + + L++ + M +++ Sbjct: 78 -DHPNIIKIFEVFED--YHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMM 134 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQ--KKLRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 AL Y HS+ ++H+D+KP N++ +++ID+GLAE + + + + Sbjct: 135 NALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMA 194 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK 260 PE+ + + D+WS G ++ ++ PF L + + +E Sbjct: 195 PEVF--KRDVTFKCDIWSAGVVMYFLLTGCLPF-----TGTSLEEVQQKATYKE-----P 242 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 320 Y ++ P ++P+A+DLL ++L D ++R +A + + Sbjct: 243 NYAVECRP-------------------------LTPQAVDLLKQMLTKDPERRPSAAQVL 277 Query: 321 EHPYF 325 H +F Sbjct: 278 HHEWF 282 >4KIK-B nrPDB Length = 677 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 53/211 (25%), Positives = 94/211 (44%), Gaps = 18/211 (8%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKI----LKPVKKKKIKREVKILENLRGGTNI 95 +++ +LG G + V N E++ +K L P +++ E++I+ L N+ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRL-THPNV 79 Query: 96 IKLIDTVKD----PVSKTPALVFEYINNTDFKQ-LYQI-----LTDFDIRFYMYELLKAL 145 + D + + P L EY D ++ L Q L + I + ++ AL Sbjct: 80 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASAL 139 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKL--RLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 Y H I+HRD+KP N+++ +++L ++ID G A+ V + + PEL Sbjct: 140 RYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 199 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFF 234 L + Q Y ++D WS G + I PF Sbjct: 200 L-EQQKYTVTVDYWSFGTLAFECITGFRPFL 229 >2UV2-A nrPDB Length = 325 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 58/222 (26%), Positives = 109/222 (49%), Gaps = 13/222 (5%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR---EVKILENLRGGT 93 +D ++++ +LG G + +V++A N + K++ +++++ E+ IL + Sbjct: 36 EDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASC-DHP 94 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTD--FKQLYQILTDFDIRFYMYELLKALDYCHSK 151 NI+KL+D + + F D +L + LT+ I+ + L AL+Y H Sbjct: 95 NIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDN 154 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELLV----D 206 I+HRD+K N++ ++L D+G+ A+ Q + + + Y+ PE+++ Sbjct: 155 KIIHRDLKAGNILF-TLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 213 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 + YDY D+WSLG L M EP H + L++IAK Sbjct: 214 DRPYDYKADVWSLGITLIEMA-EIEPPHHELNPMRVLLKIAK 254 >5TQX-A nrPDB Length = 655 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 55/249 (22%), Positives = 109/249 (43%), Gaps = 22/249 (8%) Query: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI----LKPVKKKKIKREVKILE 87 P +G +++ +LG G + V + + ++ +K L +++ E++I++ Sbjct: 2 PEFGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMK 61 Query: 88 NLRGGTNIIKLIDTVKDP---VSKTPALVFEYINNTDFKQLYQI------LTDFDIRFYM 138 L N++K D ++ + P L EY + D ++L L + I + Sbjct: 62 KLNHA-NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLL 120 Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL--RLIDWGLAEFYHPAQEYNVRVASR 196 ++ + Y H I+HRD+KP N+++ K+ ++ID G A+ + V + Sbjct: 121 SDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTL 180 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK-----VLG 251 + PEL + + Y ++D WS G M+ I PF H + +I K + Sbjct: 181 QYLAPELF-ENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFA 239 Query: 252 TEELYGYLK 260 EE+ G ++ Sbjct: 240 CEEMSGEVR 248 >2PMN-X nrPDB Length = 348 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 76/324 (23%), Positives = 153/324 (47%), Gaps = 64/324 (19%) Query: 38 DDYQLVRKLGRGKYSEV--------FEAI--------------NITNNERVVVKILKPVK 75 +DY+++R L +GK++++ F A+ +NN+++ +K K Sbjct: 31 NDYRIIRTLNQGKFNKIILCEKDNKFYALKKYEKSLLEKKRDFTKSNNDKISIK----SK 86 Query: 76 KKKIKREVKILENLRGGTNI-IKLIDTVKDPVSKTPALVFEYINNTD---FKQLYQIL-- 129 K E++I+ +++ + + I T D V +++EY+ N F + + +L Sbjct: 87 YDDFKNELQIITDIKNEYCLTCEGIITNYDEV----YIIYEYMENDSILKFDEYFFVLDK 142 Query: 130 --TDFD----IRFYMYELLKALDYCHS-KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF 182 T F I+ + +L + Y H+ K I HRDVKP N+++D + +++L D+G +E+ Sbjct: 143 NYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMD-KNGRVKLSDFGESEY 201 Query: 183 YHPAQEYNVRVASRYFKGPELLVDYQMYDYS-LDMWSLGCMLASMIFRREPFFHGQDNYD 241 + R + F PE + Y+ + +D+WSLG L M + PF Sbjct: 202 MVDKKIKGSR-GTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF-------- 252 Query: 242 QLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDL 301 ++I+ V EL+ ++ +I+ N L + K+ + + + +S E +D Sbjct: 253 -SLKISLV----ELFNNIRTKNIEYPLDRNHFLYPLTNKK-----STCSNNFLSNEDIDF 302 Query: 302 LDKLLRYDHQQRLTAKEAMEHPYF 325 L LR + +R+T+++A++H + Sbjct: 303 LKLFLRKNPAERITSEDALKHEWL 326 >3OMV-A nrPDB Length = 307 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/253 (24%), Positives = 119/253 (47%), Gaps = 43/253 (16%) Query: 15 EVNSLRSRE------YWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVV 68 E N +R R YW+ EA + L ++G G + V++ + V V Sbjct: 15 EKNKIRPRGQRDSSYYWEIEA--------SEVMLSTRIGSGSFGTVYKG---KWHGDVAV 63 Query: 69 KILK-----PVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFK 123 KILK P + + + EV +L R ++ + KD + A+V ++ + Sbjct: 64 KILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL----AIVTQWCEGSS-- 117 Query: 124 QLYQILTDFDIRFYMYELL-------KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLID 176 LY+ L + +F M++L+ + +DY H+K I+HRD+K +N+ + H+ +++ D Sbjct: 118 -LYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFL-HEGLTVKIGD 175 Query: 177 WGLAEF---YHPAQEYNVRVASRYFKGPEL--LVDYQMYDYSLDMWSLGCMLASMIFRRE 231 +GLA + +Q+ S + PE+ + D + + D++S G +L ++ Sbjct: 176 FGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGEL 235 Query: 232 PFFHGQDNYDQLV 244 P+ H +N DQ++ Sbjct: 236 PYSH-INNRDQII 247 >4YHJ-A nrPDB Length = 584 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 42/128 (32%), Positives = 65/128 (50%), Gaps = 7/128 (5%) Query: 111 ALVFEYINNTDFK-QLYQILT-DFDIR---FYMYELLKALDYCHSKGIMHRDVKPHNVMI 165 LV +N D K +Y + FD + FY EL L+ + I++RD+KP N+++ Sbjct: 261 CLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILL 320 Query: 166 DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 225 D + +R+ D GLA Q RV + + PE+ V+ + Y +S D W LGC++ Sbjct: 321 D-DRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEV-VNNEKYTFSPDWWGLGCLIYE 378 Query: 226 MIFRREPF 233 MI PF Sbjct: 379 MIQGHSPF 386 >4X3F-A nrPDB Length = 337 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 46/207 (22%), Positives = 96/207 (46%), Gaps = 15/207 (7%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKP--------VKKKKIKREVKILENLRG 91 Y+L R + G +V+EA++ RV VK+LK +++ + + + N G Sbjct: 14 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 73 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRF---YMYELLKALDYC 148 ++ ++ + +T LV E +N + + +R + + +AL Sbjct: 74 IASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIA 133 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY--HPAQEYNVRVASRYFKGPELLVD 206 H+ G++HRDVKP N++I ++++ D+G+A+ P + + + + + PE + Sbjct: 134 HAAGLVHRDVKPGNILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 192 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPF 233 + S D++SLG + + + PF Sbjct: 193 HDASPAS-DVYSLGVVGYEAVSGKRPF 218 >5HI2-A nrPDB Length = 283 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 51/215 (23%), Positives = 106/215 (49%), Gaps = 24/215 (11%) Query: 44 RKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVK 103 +++G G + V++ + V VK+L P + + K EV +L R NI+ + Sbjct: 26 QRIGSGSFGTVYKG---KWHGDVAVKMLTPQQLQAFKNEVGVLRKTRH-VNILLFMGYST 81 Query: 104 DPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELL-------KALDYCHSKGIMHR 156 P A+V ++ + LY L + +F M +L+ + +DY H+K I+HR Sbjct: 82 KP---QLAIVTQWCEGSS---LYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHR 135 Query: 157 DVKPHNVMIDHQQKKLRLIDWGLAEF---YHPAQEYNVRVASRYFKGPEL--LVDYQMYD 211 D+K +N+ + H+ +++ D+GLA + + ++ S + PE+ + D Y Sbjct: 136 DLKSNNIFL-HEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYS 194 Query: 212 YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRI 246 + D+++ G +L ++ + P+ + +N DQ++ + Sbjct: 195 FQSDVYAFGIVLYELMTGQLPYSN-INNRDQIIEM 228 >4NFN-A nrPDB Length = 309 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 38/154 (24%), Positives = 83/154 (53%), Gaps = 8/154 (5%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI-KREVKILENLRGGTNI 95 +D +++++K+G G + E++EA+++ E V +K+ + K++ K EV +L+ L+G ++ Sbjct: 20 KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHV 79 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMY---ELLKALDYCHSKG 152 + I ++ + + N D ++ Q F + + ++L++++ HS G Sbjct: 80 CRFIGCGRNEKFNYVVMQLQGRNLADLRR-SQPRGTFTLSTTLRLGKQILESIEAIHSVG 138 Query: 153 IMHRDVKPHNVMIDH---QQKKLRLIDWGLAEFY 183 +HRD+KP N + +K ++D+GLA Y Sbjct: 139 FLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 172 >6E2O-A nrPDB Length = 295 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/231 (23%), Positives = 109/231 (47%), Gaps = 21/231 (9%) Query: 20 RSREYWDYEAHVPSWGNQDDYQLVRK-LGRGKYSEVFEAINITNNERVVVKILKPVKKKK 78 RS E D E+ + + + D R LG+G Y V+ +++N R+ +K + P + + Sbjct: 3 RSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEI-PERDSR 61 Query: 79 ----IKREVKILENLRGGTNIIKLIDT------VKDPVSKTPALVFEYINNTDFKQLYQI 128 + E+ + ++L+ NI++ + + +K + + P + + + L Sbjct: 62 YSQPLHEEIALHKHLKH-KNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKD- 119 Query: 129 LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE---FYHP 185 + I FY ++L+ L Y H I+HRD+K NV+I+ L++ D+G ++ +P Sbjct: 120 -NEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINP 178 Query: 186 AQEYNVRVASRYFKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRREPFFH 235 E + + PE++ + Y + D+WSLGC + M + PF+ Sbjct: 179 CTE--TFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYE 227 >4BTK-A nrPDB Length = 337 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 38/154 (24%), Positives = 83/154 (53%), Gaps = 8/154 (5%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI-KREVKILENLRGGTNI 95 +D +++++K+G G + E++EA+++ E V +K+ + K++ K EV +L+ L+G ++ Sbjct: 55 KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHV 114 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMY---ELLKALDYCHSKG 152 + I ++ + + N D ++ Q F + + ++L++++ HS G Sbjct: 115 CRFIGCGRNEKFNYVVMQLQGRNLADLRR-SQPRGTFTLSTTLRLGKQILESIEAIHSVG 173 Query: 153 IMHRDVKPHNVMIDH---QQKKLRLIDWGLAEFY 183 +HRD+KP N + +K ++D+GLA Y Sbjct: 174 FLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 207 >4OW8-A nrPDB Length = 283 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 46/207 (22%), Positives = 96/207 (46%), Gaps = 15/207 (7%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKP--------VKKKKIKREVKILENLRG 91 Y+L R + G +V+EA++ RV VK+LK +++ + + + N G Sbjct: 13 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 72 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRF---YMYELLKALDYC 148 ++ ++ + +T LV E +N + + +R + + +AL Sbjct: 73 IASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIA 132 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY--HPAQEYNVRVASRYFKGPELLVD 206 H+ G++HRDVKP N++I ++++ D+G+A+ P + + + + + PE + Sbjct: 133 HAAGLVHRDVKPGNILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 191 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPF 233 + S D++SLG + + + PF Sbjct: 192 HDASPAS-DVYSLGVVGYEAVSGKRPF 217 >4AW2-A nrPDB Length = 437 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 102/219 (46%), Gaps = 30/219 (13%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVV-------KILKPVKKKKIKREVKILENL 89 ++D+++++ +GRG + EV + + N ++V ++LK + + E +L N Sbjct: 73 REDFEILKVIGRGAFGEV-AVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVN- 130 Query: 90 RGGTNIIKLID-TVKDPVSKTPALVFEYINNTDFKQLYQILTDFD-------IRFYMYEL 141 G + I + +D LV +Y D L +L+ F+ RFY+ E+ Sbjct: 131 -GDSKWITTLHYAFQD--DNNLYLVMDYYVGGD---LLTLLSKFEDRLPEEMARFYLAEM 184 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG--LAEFYHPAQEYNVRVASRYFK 199 + A+D H +HRD+KP N+++D +RL D+G L + +V V + + Sbjct: 185 VIAIDSVHQLHYVHRDIKPDNILMD-MNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYI 243 Query: 200 GPELLVDYQ----MYDYSLDMWSLGCMLASMIFRREPFF 234 PE+L + Y D WSLG + M++ PF+ Sbjct: 244 SPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFY 282 >3PFQ-A nrPDB Length = 674 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 61/223 (27%), Positives = 103/223 (46%), Gaps = 28/223 (12%) Query: 35 GNQD-----DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP-VKKKKIKREVKILEN 88 GN+D D+ + LG+G + +V + +E VKILK V + E ++E Sbjct: 333 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 392 Query: 89 ----LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYEL 141 L G + + + + + V EY+N D Q + F FY E+ Sbjct: 393 RVLALPGKPPFLTQLHSCFQTMDRL-YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 451 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG- 200 L + SKGI++RD+K NVM+D + +++ D+G+ + + V ++ F G Sbjct: 452 AIGLFFLQSKGIIYRDLKLDNVMLD-SEGHIKIADFGMCK-----ENIWDGVTTKTFCGT 505 Query: 201 -----PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQD 238 PE++ YQ Y S+D W+ G +L M+ + P F G+D Sbjct: 506 PDYIAPEIIA-YQPYGKSVDWWAFGVLLYEMLAGQAP-FEGED 546 >6B2Q-A nrPDB Length = 317 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 46/207 (22%), Positives = 96/207 (46%), Gaps = 15/207 (7%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKP--------VKKKKIKREVKILENLRG 91 Y+L R + G +V+EA++ RV VK+LK +++ + + + N G Sbjct: 34 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 93 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRF---YMYELLKALDYC 148 ++ ++ + +T LV E +N + + +R + + +AL Sbjct: 94 IASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIA 153 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY--HPAQEYNVRVASRYFKGPELLVD 206 H+ G++HRDVKP N++I ++++ D+G+A+ P + + + + + PE + Sbjct: 154 HAAGLVHRDVKPGNILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 212 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPF 233 + S D++SLG + + + PF Sbjct: 213 HDASPAS-DVYSLGVVGYEAVSGKRPF 238 >2OU7-A nrPDB Length = 335 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 61/290 (21%), Positives = 127/290 (43%), Gaps = 53/290 (18%) Query: 46 LGRGKYSEVFEAINITNNERVVVKI------LKPVKKKKIKREVKILENLRGGTNIIKLI 99 LG+G +++ FE + E KI LKP +++K+ E+ I +L +++ Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSL-AHQHVVGFH 107 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHSKGIMHR 156 +D + +V E +L++ LT+ + R+Y+ +++ Y H ++HR Sbjct: 108 GFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 165 Query: 157 DVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLD 215 D+K N+ ++ + ++++ D+GLA + + + V + + PE+L + + + +D Sbjct: 166 DLKLGNLFLN-EDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVD 223 Query: 216 MWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILG 275 +WS+GC++ +++ + PF + +E Y +KK + H N Sbjct: 224 VWSIGCIMYTLLVGKPPF--------------ETSCLKETYLRIKKNEYSIPKHIN---- 265 Query: 276 QHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 P A L+ K+L+ D R T E + +F Sbjct: 266 --------------------PVAASLIQKMLQTDPTARPTINELLNDEFF 295 >3TKU-A nrPDB Length = 433 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/219 (26%), Positives = 101/219 (46%), Gaps = 28/219 (12%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVV-------KILKPVKKKKIKREVKILEN 88 +++D+++++ +GRG + EV + + N ER+ ++LK + + E +L N Sbjct: 88 HREDFEIIKVIGRGAFGEV-AVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVN 146 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD-------IRFYMYEL 141 G I + + LV +Y D L +L+ F+ RFY+ E+ Sbjct: 147 --GDCQWITALHYAFQDENHL-YLVMDYYVGGD---LLTLLSKFEDKLPEDMARFYIGEM 200 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG--LAEFYHPAQEYNVRVASRYFK 199 + A+D H +HRD+KP NV++D +RL D+G L + +V V + + Sbjct: 201 VLAIDSIHQLHYVHRDIKPDNVLLD-VNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYI 259 Query: 200 GPELLVDYQ----MYDYSLDMWSLGCMLASMIFRREPFF 234 PE+L + Y D WSLG + M++ PF+ Sbjct: 260 SPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFY 298 >3DB8-A nrPDB Length = 317 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 48/204 (23%), Positives = 106/204 (51%), Gaps = 15/204 (7%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNE----RVVVK--ILKPVKKKKIKREVKILENLRGGT 93 Y R LG+G +++ +E ++ E +VV K +LKP +K+K+ E+ I ++L Sbjct: 44 YMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSL-DNP 102 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHS 150 +++ +D +V E +L++ +T+ + R++M + ++ + Y H+ Sbjct: 103 HVVGFHGFFED--DDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHN 160 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQM 209 ++HRD+K N+ ++ +++ D+GLA + + + + PE+L + Sbjct: 161 NRVIHRDLKLGNLFLNDDM-DVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCK-KG 218 Query: 210 YDYSLDMWSLGCMLASMIFRREPF 233 + + +D+WSLGC+L +++ + PF Sbjct: 219 HSFEVDIWSLGCILYTLLVGKPPF 242 >4J52-A nrPDB Length = 293 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 61/290 (21%), Positives = 127/290 (43%), Gaps = 53/290 (18%) Query: 46 LGRGKYSEVFEAINITNNERVVVKI------LKPVKKKKIKREVKILENLRGGTNIIKLI 99 LG+G +++ FE + E KI LKP +++K+ E+ I +L +++ Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSL-AHQHVVGFH 80 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHSKGIMHR 156 +D + +V E +L++ LT+ + R+Y+ +++ Y H ++HR Sbjct: 81 GFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 138 Query: 157 DVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLD 215 D+K N+ ++ + ++++ D+GLA + + + V + + PE+L + + + +D Sbjct: 139 DLKLGNLFLN-EDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVD 196 Query: 216 MWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILG 275 +WS+GC++ +++ + PF + +E Y +KK + H N Sbjct: 197 VWSIGCIMYTLLVGKPPF--------------ETSCLKETYLRIKKNEYSIPKHIN---- 238 Query: 276 QHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 P A L+ K+L+ D R T E + +F Sbjct: 239 --------------------PVAASLIQKMLQTDPTARPTINELLNDEFF 268 >2I0E-A nrPDB Length = 353 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 61/223 (27%), Positives = 103/223 (46%), Gaps = 28/223 (12%) Query: 35 GNQD-----DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP-VKKKKIKREVKILEN 88 GN+D D+ + LG+G + +V + +E VKILK V + E ++E Sbjct: 12 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 71 Query: 89 ----LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYEL 141 L G + + + + + V EY+N D Q + F FY E+ Sbjct: 72 RVLALPGKPPFLTQLHSCFQTMDRL-YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 130 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG- 200 L + SKGI++RD+K NVM+D + +++ D+G+ + + V ++ F G Sbjct: 131 AIGLFFLQSKGIIYRDLKLDNVMLD-SEGHIKIADFGMCK-----ENIWDGVTTKTFCGT 184 Query: 201 -----PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQD 238 PE++ YQ Y S+D W+ G +L M+ + P F G+D Sbjct: 185 PDYIAPEIIA-YQPYGKSVDWWAFGVLLYEMLAGQAP-FEGED 225 >4FZF-B nrPDB Length = 283 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/200 (25%), Positives = 98/200 (49%), Gaps = 13/200 (6%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKIL----KPVKKKKIKREVKILENLRGGTNI 95 + + ++G+G + EVF+ I+ + V +KI+ + + I++E+ +L + + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS-SYV 68 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI--LTDFDIRFYMYELLKALDYCHSKGI 153 K + ++ EY+ L + +F I + E+LK LDY HS+ Sbjct: 69 TKYYGSYLK--GSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKK 126 Query: 154 MHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNVRVASRYFKGPELLVDYQMYDY 212 +HRD+K NV++ +Q ++L +G+A Q + N V + ++ PE ++ YD Sbjct: 127 IHRDIKAANVLL-SEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPE-VIQQSAYDS 184 Query: 213 SLDMWSLGCMLASMIFRREP 232 D+WSLG + A + + EP Sbjct: 185 KADIWSLG-ITAIELAKGEP 203 >3C51-A nrPDB Length = 543 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 42/143 (29%), Positives = 68/143 (47%), Gaps = 22/143 (15%) Query: 111 ALVFEYINNTDFKQLYQILTDFDIR-------------------FYMYELLKALDYCHSK 151 +L + + TD + I+ DIR FY +++ L++ H + Sbjct: 249 SLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQR 308 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 I++RD+KP NV++D +R+ D GLA E + + F PELL+ + Y Sbjct: 309 NIIYRDLKPENVLLD-DDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEE-Y 366 Query: 211 DYSLDMWSLGCMLASMIFRREPF 233 D+S+D ++LG L MI R PF Sbjct: 367 DFSVDYFALGVTLYEMIAARGPF 389 >4RA4-A nrPDB Length = 355 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 61/224 (27%), Positives = 100/224 (44%), Gaps = 43/224 (19%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKL 98 D+ + LG+G + +V A E +KILK ++V I ++ T + K Sbjct: 21 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILK--------KDVVIQDDDVECTMVEKR 72 Query: 99 IDTVKDPVSKTPAL---------------VFEYINNTDFKQLYQILTDF---DIRFYMYE 140 + + D K P L V EY+N D Q + F FY E Sbjct: 73 VLALLD---KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAE 129 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 + L + H +GI++RD+K NVM+D + +++ D+G+ + + V +R F G Sbjct: 130 ISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHIKIADFGMCK-----EHMMDGVTTRTFCG 183 Query: 201 ------PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQD 238 PE++ YQ Y S+D W+ G +L M+ + P F G+D Sbjct: 184 TPDYIAPEIIA-YQPYGKSVDWWAYGVLLYEMLAGQPP-FDGED 225 >6HV0-A nrPDB Length = 416 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 55/286 (19%) Query: 62 NNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKD------PVSKTPALVFE 115 +N V VK + P REV++L N+I+ T KD + A + E Sbjct: 31 DNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQE 90 Query: 116 YINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMID----HQQKK 171 Y+ DF L + + + L + HS I+HRD+KPHN++I H + K Sbjct: 91 YVEQKDFAHL-----GLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIK 145 Query: 172 LRLIDWG----LAEFYHPAQEYNVRVASRYFKGPELLVD--YQMYDYSLDMWSLGCMLAS 225 + D+G LA H + + + PE+L + + Y++D++S GC+ Sbjct: 146 AMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYY 205 Query: 226 MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENF 285 +I +E + + K L N +LG S + Sbjct: 206 VI------------------------SEGSHPFGK----SLQRQANILLGACSL----DC 233 Query: 286 IHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKE 331 +H E V A +L++K++ D Q+R +AK ++HP+F+ + K+ Sbjct: 234 LHPEKHEDVI--ARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQ 277 >5O2B-A nrPDB Length = 285 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 61/294 (20%), Positives = 129/294 (43%), Gaps = 53/294 (18%) Query: 45 KLGRGKYSEVFEAINITNNERVVV-----KILKPVKKKKIKREVKILENLRGGTNIIKLI 99 +LGRG + V++ ++ V + L ++++ K E ++L+ L+ NI++ Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH-PNIVRFY 81 Query: 100 DTVKDPVS--KTPALVFEYINNTDFK---QLYQILTDFDIRFYMYELLKALDYCHSKG-- 152 D+ + + K LV E + + K + ++++ +R + ++LK L + H++ Sbjct: 82 DSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 141 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDY 212 I+HRD+K N+ I +++ D GLA + +V + + F PE+ ++ YD Sbjct: 142 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSV-IGTPEFMAPEMYEEH--YDE 198 Query: 213 SLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP-HFN 271 S+D+++ G + M P+ Q N Q+ R K + P FN Sbjct: 199 SVDVYAFGMCMLEMATSEYPYSECQ-NAAQIYR---------------KVTSGIKPASFN 242 Query: 272 DILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 + PE ++++ +R + +RL+ ++ + H +F Sbjct: 243 KV--------------------TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 276 >4PL5-B nrPDB Length = 435 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 72/287 (25%), Positives = 122/287 (42%), Gaps = 57/287 (19%) Query: 62 NNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKD------PVSKTPALVFE 115 +N V VK + P REV++L N+I+ T KD + A + E Sbjct: 50 DNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQE 109 Query: 116 YINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMID----HQQKK 171 Y+ DF L + +++ L + HS I+HRD+KPHN+++ H + K Sbjct: 110 YVEQKDFAHL-----GLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIK 164 Query: 172 LRLIDWG----LAEFYHPAQEYNVRVASRYFKGPELLVD--YQMYDYSLDMWSLGCMLAS 225 + D+G LA H + + + PE+L + Y++D++S GC+ Sbjct: 165 AMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYY 224 Query: 226 MIFRR-EPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWEN 284 +I PF G+ L R A +L L ++D Sbjct: 225 VISEGYHPF--GK----SLQRQANIL--------LGACNLDC------------------ 252 Query: 285 FIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKE 331 HS+ V A +L++K++ D QQR +AK ++HP+F+ + K+ Sbjct: 253 -FHSDKHEDVI--ARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQ 296 >2F57-A nrPDB Length = 317 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 46/186 (24%), Positives = 81/186 (43%), Gaps = 38/186 (20%) Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFK 199 +L+AL Y H++G++HRD+K ++++ +++L D+G A+ + V + Y+ Sbjct: 150 VLRALSYLHNQGVIHRDIKSDSILLT-SDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWM 208 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE++ Y +D+WSLG M+ MI P+F+ E + Sbjct: 209 APEVISRLP-YGTEVDIWSLGIMVIEMIDGEPPYFN-----------------EPPLQAM 250 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 ++ L P D+ H VS LD +L + QR TA+E Sbjct: 251 RRIRDSLPPRVKDL------------------HKVSSVLRGFLDLMLVREPSQRATAQEL 292 Query: 320 MEHPYF 325 + HP+ Sbjct: 293 LGHPFL 298 >5O2C-A nrPDB Length = 380 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 61/294 (20%), Positives = 129/294 (43%), Gaps = 53/294 (18%) Query: 45 KLGRGKYSEVFEAINITNNERVVV-----KILKPVKKKKIKREVKILENLRGGTNIIKLI 99 +LGRG + V++ ++ V + L ++++ K E ++L+ L+ NI++ Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH-PNIVRFY 90 Query: 100 DTVKDPVS--KTPALVFEYINNTDFK---QLYQILTDFDIRFYMYELLKALDYCHSKG-- 152 D+ + + K LV E + + K + ++++ +R + ++LK L + H++ Sbjct: 91 DSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 150 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDY 212 I+HRD+K N+ I +++ D GLA + +V + + F PE+ ++ YD Sbjct: 151 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSV-IGTPEFMAPEMYEEH--YDE 207 Query: 213 SLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP-HFN 271 S+D+++ G + M P+ Q N Q+ R K + P FN Sbjct: 208 SVDVYAFGMCMLEMATSEYPYSECQ-NAAQIYR---------------KVTSGIKPASFN 251 Query: 272 DILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 + PE ++++ +R + +RL+ ++ + H +F Sbjct: 252 KV--------------------TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 285 >2PZI-A nrPDB Length = 681 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 52/176 (29%), Positives = 85/176 (48%), Gaps = 13/176 (7%) Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-QILTDFDIRFYMYELLKALDYCHSKG 152 N ++ D DPV +V EY+ K+ Q L + Y+ E+L AL Y HS G Sbjct: 146 NFVEHTDRHGDPVGY---IVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIG 202 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDY 212 +++ D+KP N+M+ +Q L+LID G + + + F+ PE++ Sbjct: 203 LVYNDLKPENIMLTEEQ--LKLIDLGAVSRIN---SFGYLYGTPGFQAPEIV--RTGPTV 255 Query: 213 SLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 + D++++G LA++ P +G+ D L VL T + YG L + ID DP Sbjct: 256 ATDIYTVGRTLAALTLDL-PTRNGR-YVDGLPEDDPVLKTYDSYGRLLRRAIDPDP 309 >3SV0-A nrPDB Length = 483 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 47/165 (28%), Positives = 84/165 (50%), Gaps = 24/165 (14%) Query: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENL 89 P GN+ ++L RK+G G + E++ NI NE V +K L+ VK K ++ E KI L Sbjct: 3 PRVGNK--FRLGRKIGSGSFGEIYLGTNIQTNEEVAIK-LENVKTKHPQLLYESKIYRIL 59 Query: 90 RGGTNI--IKLIDT-------VKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYE 140 +GGT I ++ V D + + +F + + + +L D + Sbjct: 60 QGGTGIPNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLAD--------Q 111 Query: 141 LLKALDYCHSKGIMHRDVKPHNVM--IDHQQKKLRLIDWGLAEFY 183 ++ +++ HSK +HRD+KP N + + + ++ +ID+GLA+ Y Sbjct: 112 MINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKY 156 >6GVJ-A nrPDB Length = 429 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 75/316 (23%), Positives = 128/316 (40%), Gaps = 81/316 (25%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI--------KREVKILENLRG 91 Y +++++G G S+VF+ +N E+ + +K V ++ + E+ L L+ Sbjct: 146 YSILKQIGSGGSSKVFQVLN----EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 201 Query: 92 GTN-IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI---RFYMYELLKALDY 147 ++ II+L D + + +V E N D + D + Y +L+A+ Sbjct: 202 HSDKIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 258 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR---VASRYFKGPELL 204 H GI+H D+KP N +I L+LID+G+A P V+ V + + PE + Sbjct: 259 IHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 316 Query: 205 VDYQ----------MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE 254 D D+WSLGC+L M + + PF ++ Sbjct: 317 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQ 357 Query: 255 LYGYLKKYHIDLDPH----FNDILGQHSRKRWENFIHSENRHLVSPEA--LDLLDKLLRY 308 + + K H +DP+ F DI PE D+L L+ Sbjct: 358 IINQISKLHAIIDPNHEIEFPDI----------------------PEKDLQDVLKCCLKR 395 Query: 309 DHQQRLTAKEAMEHPY 324 D +QR++ E + HPY Sbjct: 396 DPKQRISIPELLAHPY 411 >5HIE-A nrPDB Length = 302 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 105/213 (49%), Gaps = 24/213 (11%) Query: 44 RKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVK 103 +++G G + V++ + V VK+L P + + K EV +L R NI+ + Sbjct: 42 QRIGSGSFGTVYKG---KWHGDVAVKMLTPQQLQAFKNEVGVLRKTRH-VNILLFMGYST 97 Query: 104 DPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELL-------KALDYCHSKGIMHR 156 P A+V ++ + LY L + +F M +L+ + +DY H+K I+HR Sbjct: 98 KP---QLAIVTQWCEGSS---LYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHR 151 Query: 157 DVKPHNVMIDHQQKKLRLIDWGLAEF---YHPAQEYNVRVASRYFKGPEL--LVDYQMYD 211 D+K +N+ + H+ +++ D+GLA + + ++ S + PE+ + D Y Sbjct: 152 DLKSNNIFL-HEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYS 210 Query: 212 YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLV 244 + D+++ G +L ++ + P+ + +N DQ++ Sbjct: 211 FQSDVYAFGIVLYELMTGQLPYSN-INNRDQII 242 >4U41-A nrPDB Length = 332 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 48/213 (22%), Positives = 95/213 (44%), Gaps = 23/213 (10%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK--IKREVKILENLRGGTNIIK 97 ++LV +G G Y +V++ ++ + +K++ + ++ IK E+ +L+ NI Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIAT 85 Query: 98 LIDTVKDPVSKTPA-------LVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKAL 145 + K+P LV E+ L + L + I + E+L+ L Sbjct: 86 YYGAF---IKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 142 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELL 204 + H ++HRD+K NV++ + +++L+D+G+ A+ N + + Y+ PE++ Sbjct: 143 AHLHIHHVIHRDIKGQNVLLT-ENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 201 Query: 205 VDYQ----MYDYSLDMWSLGCMLASMIFRREPF 233 + YDY D+WS G M P Sbjct: 202 ACDENPDATYDYRSDLWSCGITAIEMAEGAPPL 234 >4E93-A nrPDB Length = 377 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 58/206 (28%), Positives = 91/206 (44%), Gaps = 30/206 (14%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVK----ILKPVKKKKIKREVKILENLRG 91 N +D L ++GRG + EVF +N V VK L P K K +E +IL+ Sbjct: 112 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQY-S 170 Query: 92 GTNIIKLID--TVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLK------ 143 NI++LI T K P+ +V E + DF L R + LL+ Sbjct: 171 HPNIVRLIGVCTQKQPI----YIVMELVQGGDF---LTFLRTEGARLRVKTLLQMVGDAA 223 Query: 144 -ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-----FYHPAQEYNVRVASRY 197 ++Y SK +HRD+ N ++ ++ L++ D+G++ Y A +R Sbjct: 224 AGMEYLESKCCIHRDLAARNCLVT-EKNVLKISDFGMSREEADGVY--AASGGLRQVPVK 280 Query: 198 FKGPELLVDYQMYDYSLDMWSLGCML 223 + PE L +Y Y D+WS G +L Sbjct: 281 WTAPEAL-NYGRYSSESDVWSFGILL 305 >4PWN-A nrPDB Length = 274 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 50/213 (23%), Positives = 101/213 (47%), Gaps = 16/213 (7%) Query: 45 KLGRGKYSEVFEAINITNNERVVV-----KILKPVKKKKIKREVKILENLRGGTNIIKLI 99 ++GRG + V++ ++ V + L ++++ K E ++L+ L+ NI++ Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQH-PNIVRFY 75 Query: 100 DTVKDPVS--KTPALVFEYINNTDFK---QLYQILTDFDIRFYMYELLKALDYCHSKG-- 152 D+ + V K LV E + + K + ++++ +R + ++LK L + H++ Sbjct: 76 DSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDY 212 I+HRD+K N+ I +++ D GLA A + + F PE+ + YD Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMY--EEKYDE 193 Query: 213 SLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR 245 S+D+++ G + M P+ Q N Q+ R Sbjct: 194 SVDVYAFGMCMLEMATSEYPYSECQ-NAAQIYR 225 >3HMP-A nrPDB Length = 342 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 78/327 (23%), Positives = 133/327 (40%), Gaps = 85/327 (25%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI--------KREVKILENLRG 91 Y +++++G G S+VF+ +N E+ + +K V ++ + E+ L L+ Sbjct: 58 YSILKQIGSGGSSKVFQVLN----EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 113 Query: 92 GTN-IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI---RFYMYELLKALDY 147 ++ II+L D + + +V E N D + D + Y +L+A+ Sbjct: 114 HSDKIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 170 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR---VASRYFKGPELL 204 H GI+H D+KP N +I L+LID+G+A P V+ V + + PE + Sbjct: 171 IHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 228 Query: 205 VDYQ----------MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE 254 D D+WSLGC+L M + + PF ++ Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQ 269 Query: 255 LYGYLKKYHIDLDPH----FNDILGQHSRKRWENFIHSENRHLVSPEA--LDLLDKLLRY 308 + + K H +DP+ F DI PE D+L L+ Sbjct: 270 IINQISKLHAIIDPNHEIEFPDI----------------------PEKDLQDVLKCCLKR 307 Query: 309 DHQQRLTAKEAMEHPYFYPVVKEQSQP 335 D +QR++ E + HPY V+ Q+ P Sbjct: 308 DPKQRISIPELLAHPY----VQIQTHP 330 >2ZMD-A nrPDB Length = 390 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 78/327 (23%), Positives = 133/327 (40%), Gaps = 85/327 (25%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI--------KREVKILENLRG 91 Y +++++G G S+VF+ +N E+ + +K V ++ + E+ L L+ Sbjct: 58 YSILKQIGSGGSSKVFQVLN----EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 113 Query: 92 GTN-IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI---RFYMYELLKALDY 147 ++ II+L D + + +V E N D + D + Y +L+A+ Sbjct: 114 HSDKIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 170 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR---VASRYFKGPELL 204 H GI+H D+KP N +I L+LID+G+A P V+ V + + PE + Sbjct: 171 IHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAI 228 Query: 205 VDYQ----------MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE 254 D D+WSLGC+L M + + PF ++ Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQ 269 Query: 255 LYGYLKKYHIDLDPH----FNDILGQHSRKRWENFIHSENRHLVSPEA--LDLLDKLLRY 308 + + K H +DP+ F DI PE D+L L+ Sbjct: 270 IINQISKLHAIIDPNHEIEFPDI----------------------PEKDLQDVLKCCLKR 307 Query: 309 DHQQRLTAKEAMEHPYFYPVVKEQSQP 335 D +QR++ E + HPY V+ Q+ P Sbjct: 308 DPKQRISIPELLAHPY----VQIQTHP 330 >5X5O-A nrPDB Length = 310 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 103/207 (49%), Gaps = 25/207 (12%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIK 97 DD Q G G + V+ A I+ ++ V VK K KI++E +IL L NII+ Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVK-----KLLKIEKEAEILSVL-SHRNIIQ 68 Query: 98 LIDTVKDP-----VSKTPAL--VFEYINNTDFKQLYQILTDFD-IRFYMYELLKALDYCH 149 + +P V++ +L +++YIN+ +++ D D I + ++ K + Y H Sbjct: 69 FYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEM-----DMDHIMTWATDVAKGMHYLH 123 Query: 150 SKG---IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVD 206 + ++HRD+K NV+I L++ D+G + F++ ++ V + + PE++ Sbjct: 124 MEAPVKVIHRDLKSRNVVI-AADGVLKICDFGASRFHNHTTHMSL-VGTFPWMAPEVIQS 181 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPF 233 + + + D +S G +L M+ R PF Sbjct: 182 LPVSE-TCDTYSYGVVLWEMLTREVPF 207 >4E20-A nrPDB Length = 290 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/199 (25%), Positives = 95/199 (47%), Gaps = 17/199 (8%) Query: 43 VRKLGRGKYSEV----FEAINITNNERVVVKILK----PVKKKKIKREVKILENLRGGTN 94 +R LG G + +V ++ N E V VK LK P + +RE++IL L + Sbjct: 13 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYH-EH 71 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCHSKG 152 I+K +D K+ LV EY+ + + + + ++ + + Y H++ Sbjct: 72 IVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQH 131 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-YNVRV---ASRYFKGPELLVDYQ 208 +HR + NV++D+ + +++ D+GLA+ E Y VR + ++ PE L + + Sbjct: 132 YIHRALAARNVLLDN-DRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECK 190 Query: 209 MYDYSLDMWSLGCMLASMI 227 Y Y+ D+WS G L ++ Sbjct: 191 FY-YASDVWSFGVTLYELL 208 >6DBN-A nrPDB Length = 316 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/201 (25%), Positives = 98/201 (48%), Gaps = 19/201 (9%) Query: 43 VRKLGRGKYSEV----FEAINITNNERVVVKILKPVKKKK----IKREVKILENLRGGTN 94 +R LG G + +V ++ E+V VK LKP +K+E++IL NL N Sbjct: 40 IRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYH-EN 98 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQ-LYQILTDFDIR---FYMYELLKALDYCHS 150 I+K + L+ E++ + K+ L + +++ Y ++ K +DY S Sbjct: 99 IVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGS 158 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY----NVRVASRYFKGPELLVD 206 + +HRD+ NV+++ + ++++ D+GL + +EY + R + ++ PE L+ Sbjct: 159 RQYVHRDLAARNVLVESEH-QVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQ 217 Query: 207 YQMYDYSLDMWSLGCMLASMI 227 + Y S D+WS G L ++ Sbjct: 218 SKFYIAS-DVWSFGVTLHELL 237 >4Y12-A nrPDB Length = 375 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 52/176 (29%), Positives = 85/176 (48%), Gaps = 13/176 (7%) Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQL-YQILTDFDIRFYMYELLKALDYCHSKG 152 N ++ D DPV +V EY+ K+ Q L + Y+ E+L AL Y HS G Sbjct: 185 NFVEHTDRHGDPVGY---IVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIG 241 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDY 212 +++ D+KP N+M+ +Q L+LID G + + + F+ PE++ Sbjct: 242 LVYNDLKPENIMLTEEQ--LKLIDLGAVSRIN---SFGYLYGTPGFQAPEIVRTGPT--V 294 Query: 213 SLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 + D++++G LA++ P +G+ D L VL T + YG L + ID DP Sbjct: 295 ATDIYTVGRTLAALTLDL-PTRNGR-YVDGLPEDDPVLKTYDSYGRLLRRAIDPDP 348 >4C59-A nrPDB Length = 340 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/224 (24%), Positives = 102/224 (45%), Gaps = 32/224 (14%) Query: 44 RKLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIKREVKILENLRGGTNIIKLID 100 R L G ++ V+EA ++ + +K L + K + I +EV ++ L G NI++ Sbjct: 33 RVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCS 92 Query: 101 --TVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYM---------YELLKALDYCH 149 ++ S T F + QL + L + R + Y+ +A+ + H Sbjct: 93 AASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMH 152 Query: 150 SKG--IMHRDVKPHNVMIDHQQKKLRLIDWGLAEF--YHP-----------AQEYNVRVA 194 + I+HRD+K N+++ +Q ++L D+G A ++P +E R Sbjct: 153 RQKPPIIHRDLKVENLLLSNQ-GTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNT 211 Query: 195 SRYFKGPELLVDYQMYDYS--LDMWSLGCMLASMIFRREPFFHG 236 + ++ PE++ Y + D+W+LGC+L + FR+ PF G Sbjct: 212 TPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDG 255 >5AP3-A nrPDB Length = 313 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 78/327 (23%), Positives = 133/327 (40%), Gaps = 85/327 (25%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI--------KREVKILENLRG 91 Y +++++G G S+VF+ +N E+ + +K V ++ + E+ L L+ Sbjct: 30 YSILKQIGSGGSSKVFQVLN----EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ 85 Query: 92 GTN-IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI---RFYMYELLKALDY 147 ++ II+L D + + +V E N D + D + Y +L+A+ Sbjct: 86 HSDKIIRLYDY--EITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHT 142 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR---VASRYFKGPELL 204 H GI+H D+KP N +I L+LID+G+A P V+ V + + PE + Sbjct: 143 IHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 200 Query: 205 VDYQ----------MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE 254 D D+WSLGC+L M + + PF ++ Sbjct: 201 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQ 241 Query: 255 LYGYLKKYHIDLDPH----FNDILGQHSRKRWENFIHSENRHLVSPEA--LDLLDKLLRY 308 + + K H +DP+ F DI PE D+L L+ Sbjct: 242 IINQISKLHAIIDPNHEIEFPDI----------------------PEKDLQDVLKCCLKR 279 Query: 309 DHQQRLTAKEAMEHPYFYPVVKEQSQP 335 D +QR++ E + HPY V+ Q+ P Sbjct: 280 DPKQRISIPELLAHPY----VQIQTHP 302 >4FR4-A nrPDB Length = 384 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 44/208 (21%), Positives = 102/208 (49%), Gaps = 13/208 (6%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIKREVKILENLRGG 92 N D ++++R +G+G + +V + +K + K V++ +++ K L+ ++G Sbjct: 13 NFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGL 72 Query: 93 TN--IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDF---DIRFYMYELLKALDY 147 + ++ L + +D + +V + + D + Q F ++ ++ EL+ ALDY Sbjct: 73 EHPFLVNLWYSFQD--EEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDY 130 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 ++ I+HRD+KP N+++D + + + D+ +A + ++ + PE+ Sbjct: 131 LQNQRIIHRDMKPDNILLD-EHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSR 189 Query: 208 Q--MYDYSLDMWSLGCMLASMIFRREPF 233 + Y +++D WSLG ++ R P+ Sbjct: 190 KGAGYSFAVDWWSLGVTAYELLRGRRPY 217 >4HVI-A nrPDB Length = 314 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 48/196 (24%), Positives = 97/196 (49%), Gaps = 18/196 (9%) Query: 43 VRKLGRGKYSEV----FEAINITNNERVVVKILK---PVKKKKIKREVKILENLRGGTNI 95 + +LG+G + V ++ + V VK L+ P +++ +RE++IL+ L I Sbjct: 15 ISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHS-DFI 73 Query: 96 IKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFD-IRFYMYELLKALDYCHSK 151 +K P ++ LV EY+ + DF Q ++ D + Y ++ K ++Y S+ Sbjct: 74 VKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSR 133 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV----RVASRYFKGPELLVDY 207 +HRD+ N++++ + +++ D+GLA+ ++Y V + ++ PE L D Sbjct: 134 RCVHRDLAARNILVE-SEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSD- 191 Query: 208 QMYDYSLDMWSLGCML 223 ++ D+WS G +L Sbjct: 192 NIFSRQSDVWSFGVVL 207 >3ALO-A nrPDB Length = 327 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 68/320 (21%), Positives = 134/320 (41%), Gaps = 54/320 (16%) Query: 19 LRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVK-ILKPVKKK 77 + ++WD+ A +D + + ++GRG Y V + ++ + + + VK I V +K Sbjct: 11 ISPEQHWDFTA--------EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEK 62 Query: 78 KIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDF----KQLYQILTDFD 133 + K+ + L+ + ++ ++ + + + +T F K +Y +L D Sbjct: 63 EQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVI 122 Query: 134 IRFYMYEL----LKALDYCHSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE 188 + ++ +KAL++ I+HRD+KP N+++D + ++L D+G++ + Sbjct: 123 PEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLD-RSGNIKLCDFGISGQLVDSIA 181 Query: 189 YNVRVASRYFKGPELL---VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR 245 R + PE + Q YD D+WSLG L + R P+ +DQL + Sbjct: 182 KTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQ 241 Query: 246 IAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKL 305 + K DP +SE R SP ++ ++ Sbjct: 242 VVKG-----------------DP--------------PQLSNSEEREF-SPSFINFVNLC 269 Query: 306 LRYDHQQRLTAKEAMEHPYF 325 L D +R KE ++HP+ Sbjct: 270 LTKDESKRPKYKELLKHPFI 289 >4WUA-A nrPDB Length = 401 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 85/360 (23%), Positives = 152/360 (42%), Gaps = 77/360 (21%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK--KKKIKREVKILENLRGGTN--- 94 Y ++RKLG G +S V+ + +I + V +K++K + + E+++L+++R Sbjct: 43 YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDP 102 Query: 95 ----IIKLIDTVK-DPVSKT-PALVFEYINNTDFKQL----YQILTDFDIRFYMYELLKA 144 +++L+D K V+ T +VFE + + K + YQ L ++ + ++L+ Sbjct: 103 NREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQG 162 Query: 145 LDYCHSKG-IMHRDVKPHNVMIDHQQKKLRLI-----DW---------GLAEFYHPAQEY 189 LDY H+K I+H D+KP N+++ ++ +R + +W G A PA Sbjct: 163 LDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPATAG 222 Query: 190 N---------------VRVA-----------------SRYFKGPELLVDYQMYDYSLDMW 217 N V++A +R ++ E+L+ Y+ D+W Sbjct: 223 NFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIG-SGYNTPADIW 281 Query: 218 SLGCM---LASMIFRREPFFHGQDNY----DQLVRIAKVLG-TEELYGYLKKYHIDLDPH 269 S CM LA+ + EP H + Y D + I ++LG KY + Sbjct: 282 STACMAFELATGDYLFEP--HSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTK 339 Query: 270 FNDILGQHSRKRWENF-IHSENRHLVSPEA---LDLLDKLLRYDHQQRLTAKEAMEHPYF 325 D+ K W F + E EA D L +L ++R TA E + HP+ Sbjct: 340 KGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL 399 >3VN9-A nrPDB Length = 340 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 72/319 (22%), Positives = 133/319 (41%), Gaps = 70/319 (21%) Query: 33 SWGNQ------DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKIL 86 S GNQ DD + + +LGRG Y V + ++ + + + VK +I+ V Sbjct: 40 SIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVK--------RIRATVNSQ 91 Query: 87 ENLRGGTNIIKLIDTVKDPVSKT--PALVFE-------YINNTDFKQLY-------QILT 130 E R ++ + TV P + T AL E + +T + Y Q + Sbjct: 92 EQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIP 151 Query: 131 DFDIRFYMYELLKALDYCHSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY 189 + + ++KAL++ HSK ++HRDVKP NV+I + ++++ D+G++ + + Sbjct: 152 EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLI-NALGQVKMCDFGISGYLVDSVAK 210 Query: 190 NVRVASRYFKGPELL---VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRI 246 + + + PE + ++ + Y D+WSLG + + R P+ + QL ++ Sbjct: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV 270 Query: 247 AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLL 306 EE L + F S E +D + L Sbjct: 271 -----VEEPSPQLPA---------------------DKF---------SAEFVDFTSQCL 295 Query: 307 RYDHQQRLTAKEAMEHPYF 325 + + ++R T E M+HP+F Sbjct: 296 KKNSKERPTYPELMQHPFF 314 >3COM-A nrPDB Length = 314 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 47/201 (23%), Positives = 99/201 (49%), Gaps = 13/201 (6%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILENLRGGTNIIK 97 + ++ KLG G Y V++AI+ + V +K + PV+ ++I +E+ I++ +++K Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV-PVESDLQEIIKEISIMQQC-DSPHVVK 88 Query: 98 LIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCHSKGI 153 + + +V EY + ++ LT+ +I + LK L+Y H Sbjct: 89 YYGSYFK--NTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRK 146 Query: 154 MHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQMYDY 212 +HRD+K N++++ + +L D+G+A + + N + + ++ PE++ + Y+ Sbjct: 147 IHRDIKAGNILLN-TEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-YNC 204 Query: 213 SLDMWSLGCMLASMIFRREPF 233 D+WSLG M + P+ Sbjct: 205 VADIWSLGITAIEMAEGKPPY 225 >5H2U-A nrPDB Length = 267 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 52/224 (23%), Positives = 112/224 (50%), Gaps = 25/224 (11%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKKIKREVKILENLRGGT 93 ++++ L RKLG G + EVFE + + +V +K++ + ++ ++ E++ ++ LR Sbjct: 5 REEFTLCRKLGSGYFGEVFEGL-WKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLR-HK 62 Query: 94 NIIKL--IDTVKDPVSKTPAL-----VFEYINNTDFKQLYQILTDFDIRFYMYELLKALD 146 +I+ L + +V DPV L + E + ++D K +L ++ +++ + + Sbjct: 63 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEK----VLPVSELLDIAWQVAEGMC 118 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA----EFYHPAQEYNVRVASRYFKGPE 202 Y S+ +HRD+ N+++ + ++ D+GLA E + + ++N+ + PE Sbjct: 119 YLESQNYIHRDLAARNILVG-ENTLCKVGDFGLARLIKEDVYLSHDHNIPYK---WTAPE 174 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRI 246 L Y D+WS G +L M R + + G N++ +R+ Sbjct: 175 AL-SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRV 217 >3DAK-A nrPDB Length = 290 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 51/217 (23%), Positives = 98/217 (45%), Gaps = 21/217 (9%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRG 91 N+DDY+L +G G + V A E+V +K + K + ++ +E++ + Sbjct: 8 NRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHH 67 Query: 92 GTNIIKLIDT--VKDPVSKTPAL-----VFEYINNTDFKQLYQ--ILTDFDIRFYMYELL 142 NI+ + VKD + L V + I + K ++ +L + I + E+L Sbjct: 68 -PNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVL 126 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG-- 200 + L+Y H G +HRDVK N+++ + +++ D+G++ F + + F G Sbjct: 127 EGLEYLHKNGQIHRDVKAGNILLG-EDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTP 185 Query: 201 ----PELLVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 PE++ + YD+ D+WS G + P+ Sbjct: 186 CWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPY 222 >3CJF-A nrPDB Length = 309 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 101/213 (47%), Gaps = 28/213 (13%) Query: 37 QDDYQLVRKLGRGKYSEVFEA----INITNNERVV-VKILKP----VKKKKIKREVKILE 87 +D L + LGRG + +V EA I+ T R V VK+LK + + + E+KIL Sbjct: 26 RDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILI 85 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALV-FEYINN------------TDFKQLYQ-ILTDFD 133 ++ N++ L+ P +V F N +K LY+ LT Sbjct: 86 HIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEH 145 Query: 134 IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV 193 + Y +++ K +++ S+ +HRD+ N+++ ++ +++ D+GLA + +Y + Sbjct: 146 LICYSFQVAKGMEFLASRKCIHRDLAARNILLS-EKNVVKICDFGLARDIYKDPDYVRKG 204 Query: 194 ASRY---FKGPELLVDYQMYDYSLDMWSLGCML 223 +R + PE + D ++Y D+WS G +L Sbjct: 205 DARLPLKWMAPETIFD-RVYTIQSDVWSFGVLL 236 >4APC-A nrPDB Length = 350 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 45/212 (21%), Positives = 106/212 (50%), Gaps = 16/212 (7%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVK-----ILKPVKKKKIKREVKILENLR 90 + + Y ++K+G G + + + + + V+K + ++++ +REV +L N++ Sbjct: 22 SMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMK 81 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQ----ILTDFDIRFYMYELLKAL 145 NI++ ++ ++ + + +V +Y D FK++ + + I + ++ AL Sbjct: 82 H-PNIVQYRESFEE--NGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLAL 138 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY-NVRVASRYFKGPELL 204 + H + I+HRD+K N+ + + ++L D+G+A + E + + Y+ PE + Sbjct: 139 KHVHDRKILHRDIKSQNIFLT-KDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPE-I 196 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHG 236 + + Y+ D+W+LGC+L + + F G Sbjct: 197 CENKPYNNKSDIWALGCVLYELCTLKHAFEAG 228 >4M66-A nrPDB Length = 325 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 58/229 (25%), Positives = 102/229 (44%), Gaps = 21/229 (9%) Query: 19 LRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK 78 + S + W A ++++ + + +G+G + VF A + T N V VKI V KK Sbjct: 1 MSSVKLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKI---VNSKK 57 Query: 79 IKREVKILENLRGGTNIIKLIDTVKD---PVSKTPALVFEYINNTDFKQLYQILTDFDIR 135 I EVK + NLR N++ L+ +D ALV ++ N L Q Sbjct: 58 ISWEVKAMVNLRN-ENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWP 116 Query: 136 FY---MYELLKALDYCHS--KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-------Y 183 + E++ + Y HS ++HRD+KP N+++D + +L D+GL+ F Sbjct: 117 LLCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHA-KLADFGLSTFQGGSQSGS 175 Query: 184 HPAQEYNVRVASRYFKGPELLVDYQM-YDYSLDMWSLGCMLASMIFRRE 231 + + PELL + + D++S G ++ +++ RE Sbjct: 176 GSGSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGRE 224 >4LQP-A nrPDB Length = 508 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 41/161 (25%), Positives = 81/161 (50%), Gaps = 11/161 (6%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL--KPVKKKKIKREVKILENLRGGTN- 94 +D+ V+ +G+G + EV + +K L + KK VK ++ G++ Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 95 --IIKLIDTVKDPVSKTPALVFEYINNTDFKQL---YQILTDFDIRFYMYELLKALDYCH 149 ++ L + +D ++ L+ E++ D + +Q+ T+ RFYM E + A++ H Sbjct: 162 PWVVSLYYSFQD--AQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIH 219 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN 190 G +HR +KP N++ID + ++L D+GL+ +H + N Sbjct: 220 KLGFIHRAIKPDNILIDI-RGHIKLSDFGLSTGFHKTHDSN 259 >4IDT-A nrPDB Length = 356 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 83/208 (39%), Gaps = 26/208 (12%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTN-----IIKLI 99 +LGRG + EV + + VK K++ EV E L I+ L Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVK--------KVRLEVFRAEELMACAGLTSPRIVPLY 132 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHSKGIMHR 156 V++ + E + QL + L + +Y+ + L+ L+Y HS+ I+H Sbjct: 133 GAVRE--GPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHG 190 Query: 157 DVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL-----LVDYQMYD 211 DVK NV++ L D+G A P + Y G E +V + D Sbjct: 191 DVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCD 250 Query: 212 YSLDMWSLGCMLASMIFRREP---FFHG 236 +D+WS CM+ M+ P FF G Sbjct: 251 AKVDVWSSCCMMLHMLNGCHPWTQFFRG 278 >4TN6-A nrPDB Length = 318 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 47/165 (28%), Positives = 87/165 (52%), Gaps = 18/165 (10%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRGG 92 GN+ Y+L RK+G G + +++ +I E V +K L+ VK K ++ E KI + ++GG Sbjct: 6 GNR--YRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHIESKIYKMMQGG 62 Query: 93 TNI--IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILT-DFDIRFYMY---ELLKALD 146 I I+ D +V E + + + L+ + F ++ + +++ ++ Sbjct: 63 VGIPTIRWCGAEGD----YNVMVMELLGPS-LEDLFNFCSRKFSLKTVLLLADQMISRIE 117 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEY 189 Y HSK +HRDVKP N ++ +K + +ID+GLA+ Y A+ + Sbjct: 118 YIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTH 162 >2X7G-A nrPDB Length = 389 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 77/362 (21%), Positives = 148/362 (40%), Gaps = 83/362 (22%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK--KKKIKREVKILENLRGGTN--- 94 Y ++RKLG G +S V+ ++ V +K++K + + E+K+L+ +R Sbjct: 33 YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDP 92 Query: 95 ----IIKLIDTVKDPVSKTP----ALVFEYINNTDFKQL----YQILTDFDIRFYMYELL 142 +++LID K +S +VFE + + K + YQ L ++ + ++L Sbjct: 93 NKDMVVQLIDDFK--ISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVL 150 Query: 143 KALDYCHSKG-IMHRDVKPHNVMI------------------------------------ 165 + LDY HSK I+H D+KP N+++ Sbjct: 151 QGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPAA 210 Query: 166 ----------DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLD 215 + + ++++ D G A + H + + + +R ++ E+L+ Y D Sbjct: 211 DLLVNPLDPRNADKIRVKIADLGNACWVH--KHFTEDIQTRQYRSIEVLIGAG-YSTPAD 267 Query: 216 MWSLGCM---LASMIFRREPFFHGQDNY----DQLVRIAKVLGT-EELYGYLKKYHIDLD 267 +WS CM LA+ + EP H ++Y D + I ++LG+ + KY + Sbjct: 268 IWSTACMAFELATGDYLFEP--HSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFF 325 Query: 268 PHFNDILGQHSRKRWENFIHSENR----HLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 ++ K W F + H + + D L +L ++R +A E + HP Sbjct: 326 NRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHP 385 Query: 324 YF 325 + Sbjct: 386 WL 387 >5X02-A nrPDB Length = 347 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 62/243 (25%), Positives = 111/243 (45%), Gaps = 51/243 (20%) Query: 22 REY-WDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEA----INITN-NERVVVKILK--- 72 REY +D + P +++ + + LG G + +V A I+ T + +V VK+LK Sbjct: 35 REYEYDLKWEFP----RENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA 90 Query: 73 -PVKKKKIKREVKILENLRGGTNIIKLID--TVKDPVSKTPALVFEYINNTDF------- 122 +++ + E+K++ L NI+ L+ T+ P+ L+FEY D Sbjct: 91 DSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPI----YLIFEYCCYGDLLNYLRSK 146 Query: 123 --------------KQLYQ-----ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNV 163 K+L + +LT D+ + Y++ K +++ K +HRD+ NV Sbjct: 147 REKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNV 206 Query: 164 MIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLG 220 ++ H K +++ D+GLA Y VR +R + PE L + +Y D+WS G Sbjct: 207 LVTH-GKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYG 264 Query: 221 CML 223 +L Sbjct: 265 ILL 267 >2VD5-A nrPDB Length = 412 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 81/315 (25%), Positives = 127/315 (40%), Gaps = 65/315 (20%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR-EVKILENLR---- 90 +DD+++++ +GRG +SEV + +KI+ K +KR EV R Sbjct: 59 QRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMN--KWDMLKRGEVSCFREERDVLV 116 Query: 91 GGTN--IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD-------IRFYMYEL 141 G I +L +D LV EY D L +L+ F RFY+ E+ Sbjct: 117 NGDRRWITQLHFAFQD--ENYLYLVMEYYVGGD---LLTLLSKFGERIPAEMARFYLAEI 171 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG--LAEFYHPAQEYNVRVASRYFK 199 + A+D H G +HRD+KP N+++D + +RL D+G L V V + + Sbjct: 172 VMAIDSVHRLGYVHRDIKPDNILLD-RCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYL 230 Query: 200 GPELL------VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTE 253 PE+L Y D W+LG M + + PF+ T Sbjct: 231 SPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADS--------------TA 276 Query: 254 ELYGYLKKY--HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQ 311 E YG + Y H+ L P ++ + + +R +FI R L PE Sbjct: 277 ETYGKIVHYKEHLSL-PLVDEGVPEEAR----DFIQ---RLLCPPET-----------RL 317 Query: 312 QRLTAKEAMEHPYFY 326 R A + HP+F+ Sbjct: 318 GRGGAGDFRTHPFFF 332 >4XUF-A nrPDB Length = 297 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/227 (25%), Positives = 104/227 (45%), Gaps = 46/227 (20%) Query: 37 QDDYQLVRKLGRGKYSEVFEA----INITN-NERVVVKILK----PVKKKKIKREVKILE 87 +++ + + LG G + +V A I+ T + +V VK+LK +++ + E+K++ Sbjct: 8 RENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMT 67 Query: 88 NLRGGTNIIKLID--TVKDPVSKTPALVFEYINNTDF---------------------KQ 124 L NI+ L+ T+ P+ L+FEY D K+ Sbjct: 68 QLGSHENIVNLLGACTLSGPI----YLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKR 123 Query: 125 LYQ-----ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL 179 L + +LT D+ + Y++ K +++ K +HRD+ NV++ H K +++ D+GL Sbjct: 124 LEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKICDFGL 182 Query: 180 AEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 223 A Y VR +R + PE L + +Y D+WS G +L Sbjct: 183 ARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILL 228 >3A4O-X nrPDB Length = 286 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 56/242 (23%), Positives = 116/242 (47%), Gaps = 36/242 (14%) Query: 25 WDYEA-HVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP--VKKKKIKR 81 WD +A +P ++ +LV++LG G++ EV+ N+ +V VK LKP + + Sbjct: 3 WDKDAWEIP----RESIKLVKRLGAGQFGEVWMGY-YNNSTKVAVKTLKPGTMSVQAFLE 57 Query: 82 EVKILENLRGGTNIIKL--IDTVKDPVSKTPALVFEYINNT---DF-------KQLYQIL 129 E +++ L+ +++L + T ++P+ ++ EY+ DF K L L Sbjct: 58 EANLMKTLQH-DKLVRLYAVVTREEPIY----IITEYMAKGSLLDFLKSDEGGKVLLPKL 112 Query: 130 TDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY 189 DF ++ + + Y K +HRD++ NV++ + ++ D+GLA EY Sbjct: 113 IDFSA-----QIAEGMAYIERKNYIHRDLRAANVLV-SESLMCKIADFGLARVIED-NEY 165 Query: 190 NVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRI 246 R +++ + PE +++ + D+WS G +L ++ + + G+ N D + + Sbjct: 166 TAREGAKFPIKWTAPE-AINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTAL 224 Query: 247 AK 248 ++ Sbjct: 225 SQ 226 >4G3E-A nrPDB Length = 352 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 48/202 (23%), Positives = 83/202 (41%), Gaps = 23/202 (11%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTN-----IIKLI 99 ++GRG + EV + + VK K++ EV +E L I+ L Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVK--------KVRLEVFRVEELVACAGLSSPRIVPLY 132 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHSKGIMHR 156 V++ + E + QL + L + +Y+ + L+ L+Y H++ I+H Sbjct: 133 GAVRE--GPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHG 190 Query: 157 DVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL-----LVDYQMYD 211 DVK NV++ + L D+G A P + Y G E +V + D Sbjct: 191 DVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCD 250 Query: 212 YSLDMWSLGCMLASMIFRREPF 233 +D+WS CM+ M+ P+ Sbjct: 251 AKVDIWSSCCMMLHMLNGCHPW 272 >4H1J-A nrPDB Length = 293 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/218 (24%), Positives = 101/218 (46%), Gaps = 21/218 (9%) Query: 32 PSWG-NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-------KKIKREV 83 P +G ++D L R LG G + EV+E + + + +K KK +K E Sbjct: 17 PQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEA 76 Query: 84 KILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDF----KQLYQILTDFDIRFYMY 139 I++NL +I+KLI +++ + ++ Y + K ++LT + Y Sbjct: 77 VIMKNL-DHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLT---LVLYSL 132 Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK 199 ++ KA+ Y S +HRD+ N+++ + ++L D+GL+ + Y V K Sbjct: 133 QICKAMAYLESINCVHRDIAVRNILVASPE-CVKLGDFGLSRYIEDEDYYKASVTRLPIK 191 Query: 200 --GPELLVDYQMYDYSLDMWSLG-CMLASMIFRREPFF 234 PE ++++ + + D+W CM + F ++PFF Sbjct: 192 WMSPE-SINFRRFTTASDVWMFAVCMWEILSFGKQPFF 228 >2DQ7-X nrPDB Length = 283 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 50/226 (22%), Positives = 105/226 (46%), Gaps = 26/226 (11%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP--VKKKKIKREVKILENLRGGTN 94 ++ QL+++LG G++ EV+ N +V +K LKP + + E +I++ L+ Sbjct: 8 RESLQLIKRLGNGQFGEVWMG-TWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLK-HDK 65 Query: 95 IIKLIDTV-KDPVSKTPALVFEYINNTDFKQLYQILTDFDIRF--------YMYELLKAL 145 +++L V ++P+ +V EY+N L L D + R ++ + Sbjct: 66 LVQLYAVVSEEPIY----IVTEYMNKGS---LLDFLKDGEGRALKLPNLVDMAAQVAAGM 118 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPE 202 Y +HRD++ N+++ + ++ D+GLA EY R +++ + PE Sbjct: 119 AYIERMNYIHRDLRSANILVGNGL-ICKIADFGLARLIE-DNEYTARQGAKFPIKWTAPE 176 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 + Y + D+WS G +L ++ + + G +N + L ++ + Sbjct: 177 AAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVER 221 >3FME-A nrPDB Length = 290 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 68/308 (22%), Positives = 129/308 (41%), Gaps = 64/308 (20%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIK 97 DD + + +LGRG Y V + ++ + + + VK +I+ V E R ++ Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVK--------RIRATVNSQEQKRLLMDLDI 58 Query: 98 LIDTVKDPVSKT--PALVFE-------YINNTDFKQLY-------QILTDFDIRFYMYEL 141 + TV P + T AL E + +T + Y Q + + + + Sbjct: 59 SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 118 Query: 142 LKALDYCHSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 +KAL++ HSK ++HRDVKP NV+I + ++++ D+G++ + ++ + + Sbjct: 119 VKALEHLHSKLSVIHRDVKPSNVLI-NALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMA 177 Query: 201 PELL---VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 PE + ++ + Y D+WSLG + + R P+ + QL ++ EE Sbjct: 178 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV-----VEEPSP 232 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317 L + F S E +D + L+ + ++R T Sbjct: 233 QLPA---------------------DKF---------SAEFVDFTSQCLKKNSKERPTYP 262 Query: 318 EAMEHPYF 325 E M+HP+F Sbjct: 263 ELMQHPFF 270 >5TE0-A nrPDB Length = 347 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 50/183 (27%), Positives = 87/183 (47%), Gaps = 27/183 (14%) Query: 79 IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIR--- 135 KRE++I+ +L G NI+ ID+ + VS V+E + DF + Q++ + R Sbjct: 62 CKREIQIMRDLSGHKNIVGYIDSSINNVSS--GDVWEVLILMDFCRGGQVVNLMNQRLQT 119 Query: 136 -FYMYELLKAL-DYCHSKG--------IMHRDVKPHNVMIDHQQKKLRLIDWGLA--EFY 183 F E+L+ D C + I+HRD+K N+++ H + L D+G A +F Sbjct: 120 GFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILL-HDRGHYVLCDFGSATNKFQ 178 Query: 184 HPAQEYNVRV-------ASRYFKGPELLVDY--QMYDYSLDMWSLGCMLASMIFRREPFF 234 +P E V + ++ PE++ Y ++ D+W+LGC+L + + PF Sbjct: 179 NPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFG 238 Query: 235 HGQ 237 Q Sbjct: 239 ESQ 241 >5DBX-A nrPDB Length = 328 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 51/217 (23%), Positives = 98/217 (45%), Gaps = 23/217 (10%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGG 92 +D Y+L +G G + V A+ ERV +K + K + ++ +E++ + Sbjct: 10 RDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQC-SH 68 Query: 93 TNIIKLIDT--VKDPVSKTPAL--------VFEYINNTDFKQLYQILTDFDIRFYMYELL 142 N++ + VKD + L + +YI N + +L + I + E+L Sbjct: 69 PNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRG-EHKNGVLEEAIIATILKEVL 127 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN---VR---VASR 196 + LDY H G +HRD+K N+++ + +++ D+G++ F + VR V + Sbjct: 128 EGLDYLHRNGQIHRDLKAGNILLG-EDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTP 186 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 + PE++ + YD+ DMWS G + P+ Sbjct: 187 CWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPY 223 >4LG4-A nrPDB Length = 299 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 46/204 (22%), Positives = 98/204 (48%), Gaps = 13/204 (6%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILENLRGGTN 94 ++ + ++ KLG G Y VF+AI+ + + V +K + PV+ ++I +E+ I++ Sbjct: 10 EEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESDLQEIIKEISIMQQCDSPYV 68 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCHS 150 + K+ +V EY + ++ L + +I + LK L+Y H Sbjct: 69 VKYYGSYFKN---TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 125 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQM 209 +HR++K N++++ + +L D+G+A + + N + + ++ PE++ + Sbjct: 126 MRKIHRNIKAGNILLN-TEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG- 183 Query: 210 YDYSLDMWSLGCMLASMIFRREPF 233 Y+ D+WSLG M + P+ Sbjct: 184 YNCVADIWSLGITSIEMAEGKPPY 207 >5GRN-A nrPDB Length = 356 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 104/227 (45%), Gaps = 43/227 (18%) Query: 37 QDDYQLVRKLGRGKYSEVFE--AINITNNE---RVVVKILKPV----KKKKIKREVKILE 87 +D L R LG G + +V E A ++ ++ +V VK+LKP +K+ + E+KI+ Sbjct: 45 RDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMT 104 Query: 88 NLRGGTNIIKLID--TVKDPVSKTPALVF--EYIN------------------NTDFKQL 125 +L NI+ L+ T P+ F + +N +++ K L Sbjct: 105 HLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNL 164 Query: 126 Y-----QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180 + LT D+ + Y++ + +++ SK +HRD+ NV++ Q K +++ D+GLA Sbjct: 165 LSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLL-AQGKIVKICDFGLA 223 Query: 181 EFYHPAQEYNVRVASRY----FKGPELLVDYQMYDYSLDMWSLGCML 223 Y V S + + PE + D +Y D+WS G +L Sbjct: 224 RDIMHDSNY-VSKGSTFLPVKWMAPESIFD-NLYTTLSDVWSYGILL 268 >4EBW-A nrPDB Length = 304 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 52/221 (23%), Positives = 99/221 (44%), Gaps = 23/221 (10%) Query: 41 QLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-------KKKIKREVKILENLRGGT 93 +L R +G G++ +V + I ++ + +K K ++K +E + Sbjct: 41 ELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQF-DHP 99 Query: 94 NIIKLIDTV-KDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYC 148 +I+KLI + ++PV ++ E + + Q+ L + Y Y+L AL Y Sbjct: 100 HIVKLIGVITENPV----WIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYL 155 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK--GPELLVD 206 SK +HRD+ NV++ ++L D+GL+ + + Y K PE ++ Sbjct: 156 ESKRFVHRDIAARNVLVSSND-CVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE-SIN 213 Query: 207 YQMYDYSLDMWSLG-CMLASMIFRREPFFHGQDNYDQLVRI 246 ++ + + D+W G CM ++ +P F G N D + RI Sbjct: 214 FRRFTSASDVWMFGVCMWEILMHGVKP-FQGVKNNDVIGRI 253 >6AO5-A nrPDB Length = 362 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 46/201 (22%), Positives = 98/201 (48%), Gaps = 13/201 (6%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILENLRGGTNIIK 97 + ++ KLG G Y VF+AI+ + + V +K + PV+ ++I +E+ I++ ++K Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESDLQEIIKEISIMQQC-DSPYVVK 69 Query: 98 LIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCHSKGI 153 + + +V EY + ++ L + +I + LK L+Y H Sbjct: 70 YYGSYFK--NTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRK 127 Query: 154 MHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQMYDY 212 +HR++K N++++ + +L D+G+A + + N + + ++ PE++ + Y+ Sbjct: 128 IHRNIKAGNILLN-TEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-YNC 185 Query: 213 SLDMWSLGCMLASMIFRREPF 233 D+WSLG M + P+ Sbjct: 186 VADIWSLGITSIEMAEGKPPY 206 >2CMW-A nrPDB Length = 310 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 42/149 (28%), Positives = 73/149 (48%), Gaps = 11/149 (7%) Query: 44 RKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRGGTNIIKLIDT 101 +K+G G + E+ N+ NE V +K L+P+K + ++ E + + L + + Sbjct: 6 KKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYY 64 Query: 102 VKDPVSKTPALVFEYINNTD---FKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDV 158 P K A+V E + + F + T + +LL ++Y HSK +++RDV Sbjct: 65 F-GPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDV 123 Query: 159 KPHNVMIDHQQKK----LRLIDWGLAEFY 183 KP N +I Q K + +ID+GLA+ Y Sbjct: 124 KPENFLIGRQGNKKEHVIHIIDFGLAKEY 152 >2CHL-A nrPDB Length = 351 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 41/155 (26%), Positives = 83/155 (53%), Gaps = 14/155 (9%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRGGTNII 96 ++++ +K+G G + E+ N+ NE V +K L+P+K + ++ E + + L G I Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSGDGIP 89 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQILT-DFDIRFYMY---ELLKALDYCHSKG 152 ++ P K A+V E + + + L+ + F ++ + +L+ ++Y HSK Sbjct: 90 QVY--YFGPCGKYNAMVLELLGPS-LEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKN 146 Query: 153 IMHRDVKPHNVMI----DHQQKKLRLIDWGLAEFY 183 +++RDVKP N +I + Q+ + +ID+ LA+ Y Sbjct: 147 LIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEY 181 >6CTH-A nrPDB Length = 309 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 56/212 (26%), Positives = 97/212 (45%), Gaps = 20/212 (9%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR---EVKILENLRGGTN 94 ++ KLG G + V+ ++ + VK + K+ IK EVKI+ LR N Sbjct: 15 SNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRH-KN 73 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMY-ELLKALDYCHS 150 ++KLI + LV+E++ N + L +++R+ + +L AL Y H Sbjct: 74 LVKLIGWCHE--RGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHE 131 Query: 151 KG---IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ--EYNVRVASRYFKGPELLV 205 +G ++HRD+K N+M+D +L D+GLA A+ + + + + PE L Sbjct: 132 EGDHCVLHRDIKTSNIMLDSSFNA-KLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLS 190 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRR---EPFF 234 + S D++S G + + R EP F Sbjct: 191 SGKASKES-DVYSFGVVALEIASGRRSIEPKF 221 >4AN9-A nrPDB Length = 301 Score = 53.9 bits (128), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 93/210 (44%), Gaps = 28/210 (13%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL----KPVKKKKIKREVKILENLRGGT 93 DD++ + +LG G VF+ + + + K++ KP + +I RE+++L Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 67 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--------QILTDFDIRFYMYELLKAL 145 I+ ++ E+++ Q+ QIL I ++K L Sbjct: 68 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSI-----AVIKGL 120 Query: 146 DYCHSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAE--FYHPAQEYNVRVASRYFKGPE 202 Y K IMHRDVKP N++++ + +++L D+G++ A E+ V +R + PE Sbjct: 121 TYLREKHKIMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDEMANEF---VGTRSYMSPE 176 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREP 232 L Y D+WS+G L M R P Sbjct: 177 RLQGTH-YSVQSDIWSMGLSLVEMAVGRYP 205 >5KKR-C nrPDB Length = 395 Score = 53.9 bits (128), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 52/209 (24%), Positives = 92/209 (44%), Gaps = 24/209 (11%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL----KPVKKKKIKREVKILENLRGGT 93 DD++ + +LG G VF+ + + + K++ KP + +I RE+++L Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 126 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--------QILTDFDIRFYMYELLKAL 145 I+ ++ E+++ Q+ QIL I ++K L Sbjct: 127 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSI-----AVIKGL 179 Query: 146 DYCHSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL 204 Y K IMHRDVKP N++++ + +++L D+G++ + N V +R + PE L Sbjct: 180 TYLREKHKIMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSM-ANSFVGTRSYMSPERL 237 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPF 233 Y D+WS+G L M R P Sbjct: 238 QGTH-YSVQSDIWSMGLSLVEMAVGRYPI 265 >3EQC-A nrPDB Length = 360 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 52/209 (24%), Positives = 92/209 (44%), Gaps = 24/209 (11%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL----KPVKKKKIKREVKILENLRGGT 93 DD++ + +LG G VF+ + + + K++ KP + +I RE+++L Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 91 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--------QILTDFDIRFYMYELLKAL 145 I+ ++ E+++ Q+ QIL I ++K L Sbjct: 92 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSI-----AVIKGL 144 Query: 146 DYCHSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL 204 Y K IMHRDVKP N++++ + +++L D+G++ + N V +R + PE L Sbjct: 145 TYLREKHKIMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERL 202 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPF 233 Y D+WS+G L M R P Sbjct: 203 QGTH-YSVQSDIWSMGLSLVEMAVGRYPI 230 >3GQL-A nrPDB Length = 326 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 64/267 (23%), Positives = 113/267 (42%), Gaps = 53/267 (19%) Query: 32 PSWG-NQDDYQLVRKLGRGKYSEVF--EAINITNNE-----RVVVKILKPVKKKK----I 79 P W +D L + LG G + +V EAI + ++ +V VK+LK +K + Sbjct: 21 PRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 80 Query: 80 KREVKILENLRGGTNIIKLIDTVKDPVSKTPA-LVFEYINNTDFKQLYQI---------- 128 E+++++ + NII L+ P ++ EY + + ++ Q Sbjct: 81 ISEMEMMKMIGKHKNIINLLGAC---TQDGPLYVIVEYASKGNLREYLQARRPPGLEYCY 137 Query: 129 ---------LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL 179 L+ D+ Y++ + ++Y SK +HRD+ NV++ + +++ D+GL Sbjct: 138 NPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFGL 196 Query: 180 AEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHG 236 A H Y R + PE L D ++Y + D+WS G +L E F G Sbjct: 197 ARDIHHIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLW------EIFTLG 249 Query: 237 QDNYDQLVRIAKVLGTEELYGYLKKYH 263 Y + EEL+ LK+ H Sbjct: 250 GSPYPG-------VPVEELFKLLKEGH 269 >5A46-A nrPDB Length = 386 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 64/267 (23%), Positives = 113/267 (42%), Gaps = 53/267 (19%) Query: 32 PSWG-NQDDYQLVRKLGRGKYSEVF--EAINITNNE-----RVVVKILKPVKKKK----I 79 P W +D L + LG G + +V EAI + ++ +V VK+LK +K + Sbjct: 33 PRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 92 Query: 80 KREVKILENLRGGTNIIKLIDTVKDPVSKTPA-LVFEYINNTDFKQLYQI---------- 128 E+++++ + NII L+ P ++ EY + + ++ Q Sbjct: 93 ISEMEMMKMIGKHKNIINLLGAC---TQDGPLYVIVEYASKGNLREYLQARRPPGLEYCY 149 Query: 129 ---------LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL 179 L+ D+ Y++ + ++Y SK +HRD+ NV++ + +++ D+GL Sbjct: 150 NPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFGL 208 Query: 180 AEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHG 236 A H Y R + PE L D ++Y + D+WS G +L E F G Sbjct: 209 ARDIHHIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLW------EIFTLG 261 Query: 237 QDNYDQLVRIAKVLGTEELYGYLKKYH 263 Y + EEL+ LK+ H Sbjct: 262 GSPYPGVP-------VEELFKLLKEGH 281 >3TT0-A nrPDB Length = 382 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 65/268 (24%), Positives = 115/268 (42%), Gaps = 55/268 (20%) Query: 32 PSWG-NQDDYQLVRKLGRGKYSEVF--EAINITNNE-----RVVVKILKPVKKKK----I 79 P W +D L + LG G + +V EAI + ++ +V VK+LK +K + Sbjct: 62 PRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 121 Query: 80 KREVKILENLRGGTNIIKLID--TVKDPVSKTPALVFEYINNTDFKQLYQI--------- 128 E+++++ + NII L+ T P+ ++ EY + + ++ Q Sbjct: 122 ISEMEMMKMIGKHKNIINLLGACTQDGPLY----VIVEYASKGNLREYLQARRPPGLEYS 177 Query: 129 ----------LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG 178 L+ D+ Y++ + ++Y SK +HRD+ NV++ + +++ D+G Sbjct: 178 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFG 236 Query: 179 LAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFH 235 LA H Y R + PE L D ++Y + D+WS G +L E F Sbjct: 237 LARDIHHIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLW------EIFTL 289 Query: 236 GQDNYDQLVRIAKVLGTEELYGYLKKYH 263 G Y + EEL+ LK+ H Sbjct: 290 GGSPYPGVP-------VEELFKLLKEGH 310 >2J0K-A nrPDB Length = 656 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 52/221 (23%), Positives = 99/221 (44%), Gaps = 23/221 (10%) Query: 41 QLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-------KKKIKREVKILENLRGGT 93 +L R +G G++ +V + I ++ + +K K ++K +E + Sbjct: 393 ELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQF-DHP 451 Query: 94 NIIKLIDTV-KDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYC 148 +I+KLI + ++PV ++ E + + Q+ L + Y Y+L AL Y Sbjct: 452 HIVKLIGVITENPV----WIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYL 507 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK--GPELLVD 206 SK +HRD+ NV++ ++L D+GL+ + + Y K PE ++ Sbjct: 508 ESKRFVHRDIAARNVLVSATD-CVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE-SIN 565 Query: 207 YQMYDYSLDMWSLG-CMLASMIFRREPFFHGQDNYDQLVRI 246 ++ + + D+W G CM ++ +P F G N D + RI Sbjct: 566 FRRFTSASDVWMFGVCMWEILMHGVKP-FQGVKNNDVIGRI 605 >6BXI-A nrPDB Length = 333 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 58/241 (24%), Positives = 107/241 (44%), Gaps = 50/241 (20%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKK---IKREVKILENLRG 91 +D++ ++ +GRG + EV +KIL+ ++K++ I+ E IL Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE-AD 64 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYC 148 ++K+ + +D ++ L+ E++ D L LT+ + +FY+ E + A+D Sbjct: 65 SLWVVKMFYSFQDKLNL--YLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSI 122 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA---------EFYH------PA----QEY 189 H G +HRD+KP N+++D + ++L D+GL EFY P+ Q Sbjct: 123 HQLGFIHRDIKPDNLLLD-SKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNM 181 Query: 190 NVRVASRYFK-----------------GPELLVDYQMYDYSLDMWSLGCMLASMIFRREP 232 N + + +K PE+ + Y+ D WSLG ++ M+ P Sbjct: 182 NSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-YNKLCDWWSLGVIMYEMLIGYPP 240 Query: 233 F 233 F Sbjct: 241 F 241 >2BUJ-A nrPDB Length = 317 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/237 (23%), Positives = 114/237 (48%), Gaps = 27/237 (11%) Query: 21 SREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL---KPVKKK 77 RE ++ H+ N+ Y ++KLG G +S V + + +K + + ++ Sbjct: 13 GRENLYFQGHMVIIDNKH-YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDRE 71 Query: 78 KIKREVKILENLRGGTNIIKLID-TVKDPVSKTPA--LVFEYINNTDFKQLYQI------ 128 + +RE + L NI++L+ +++ +K A L+ + T + ++ ++ Sbjct: 72 EAQREAD-MHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNF 130 Query: 129 LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL-------AE 181 LT+ I + + + + L+ H+KG HRD+KP N+++ + + + L+D G E Sbjct: 131 LTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPV-LMDLGSMNQACIHVE 189 Query: 182 FYHPA---QEYNVRVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIFRREPF 233 A Q++ + + ++ PEL + + D D+WSLGC+L +M+F P+ Sbjct: 190 GSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY 246 >4CSV-A nrPDB Length = 275 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 51/220 (23%), Positives = 102/220 (46%), Gaps = 28/220 (12%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGTN 94 + + L RKLG G++ EV+E N V VK LK + ++ +E +I++ L+ N Sbjct: 10 RSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKKLK-HPN 68 Query: 95 IIKL--IDTVKDPV-----SKTPALVFEYINNTDFKQL-YQILTDFDIRFYMYELLKALD 146 +++L + T + P+ + + +Y+ + + + Q L D ++ + Sbjct: 69 LVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAA-----QVASGMA 123 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPEL 203 Y S+ +HRD+ N ++ + +++ D+GLA + EY R +++ + PE Sbjct: 124 YLESQNFIHRDLAARNCLVG-ENNVVKVADFGLARLIN-EDEYTARAGAKFPIKWTAPE- 180 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQL 243 + Y + D+W+ G +L E F +GQ Y + Sbjct: 181 AISYNRFSIKSDVWAFGILL------WEIFTYGQVPYPGM 214 >2C47-A nrPDB Length = 313 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 38/154 (24%), Positives = 78/154 (50%), Gaps = 12/154 (7%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRGGTNII 96 ++++ +K+G G + E+ N+ NE V +K L+P+K + ++ E + + L + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLSATEGVP 63 Query: 97 KLIDTVKDPVSKTPALVFEYINNTD---FKQLYQILTDFDIRFYMYELLKALDYCHSKGI 153 ++ P K A+V E + + F + T + +L+ ++Y H+K + Sbjct: 64 QVY--YFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSL 121 Query: 154 MHRDVKPHNVMIDH----QQKKLRLIDWGLAEFY 183 ++RDVKP N ++ +Q + +ID+GLA+ Y Sbjct: 122 IYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEY 155 >6GQK-A nrPDB Length = 328 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 59/230 (25%), Positives = 95/230 (41%), Gaps = 45/230 (19%) Query: 44 RKLGRGKYSEVFEA-----INITNNERVVVKILKP----VKKKKIKREVKILENLRGGTN 94 + LG G + +V EA I V VK+LKP +++ + E+K+L L N Sbjct: 47 KTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHEN 106 Query: 95 IIKLIDTVKDPVSKTPALVF-EYINNTDF------------------KQLYQ-ILTDFDI 134 I+ L+ P LV EY D + LY+ LT + Sbjct: 107 IVNLLGAC---THGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHL 163 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY----N 190 + Y++ K + + SK +HRD+ N+++ H ++ D+GLA Y N Sbjct: 164 LSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNIT-KICDFGLARDIKNDSNYVDKGN 222 Query: 191 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240 R+ ++ PE + + +Y + D+WS G IF E F G Y Sbjct: 223 ARLPVKWM-APESIFN-SVYTFESDVWSYG------IFLWELFSLGSSPY 264 >4M7I-A nrPDB Length = 299 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 50/223 (22%), Positives = 104/223 (46%), Gaps = 36/223 (16%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK----PVKKKKIKREVKILENLRGGTN 94 D++ ++ LGRG + VFEA N ++ +K ++ + ++K+ REVK L L Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEH-PG 64 Query: 95 IIK-----LIDTVKDPVSKTPALVFEYI--------NNTDFKQLYQILTDFDIRFYMY-- 139 I++ L + + + V+ YI N D+ + + + ++ Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124 Query: 140 -ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE---------- 188 ++ +A+++ HSKG+MHRD+KP N+ +++ D+GL +E Sbjct: 125 LQIAEAVEFLHSKGLMHRDLKPSNIFFT-MDDVVKVGDFGLVTAMDQDEEEQTVLTPMPA 183 Query: 189 ---YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 228 + +V ++ + PE + Y + +D++SLG +L +++ Sbjct: 184 YARHTGQVGTKLYMSPE-QIHGNSYSHKVDIFSLGLILFELLY 225 >5O0Y-A nrPDB Length = 579 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 70/309 (22%), Positives = 130/309 (42%), Gaps = 62/309 (20%) Query: 51 YSEVFEAINITNNERVVVKILKPVKK----------KKIKREVKILENLRGGTNIIKLID 100 +SEV++A ++T V VKI + K K RE +I + L I+KL D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL-DHPRIVKLYD 355 Query: 101 TVK-DPVSKTPALVFEYINNTDF--KQLYQILTDFDIRFYMYELLKALDYCHS--KGIMH 155 D S L + N+ DF KQ ++++++ + R + +++ AL Y + I+H Sbjct: 356 YFSLDTDSFCTVLEYCEGNDLDFYLKQ-HKLMSEKEARSIIMQIVNALKYLNEIKPPIIH 414 Query: 156 RDVKPHNVMIDHQQK--KLRLIDWGLAEFYH-------PAQEYNVRVASRY-FKGPELLV 205 D+KP N+++ + ++++ D+GL++ E + A Y + PE V Sbjct: 415 YDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFV 474 Query: 206 ---DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 + +D+WS+G + ++ R+PF H Q D L + TE Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE--------- 525 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 + P + +V+PEA + + L Y + R+ ++ Sbjct: 526 -VQFPP----------------------KPVVTPEAKAFIRRCLAYRKEDRIDVQQLACD 562 Query: 323 PYFYPVVKE 331 PY P +++ Sbjct: 563 PYLLPHIRK 571 >2W1I-A nrPDB Length = 326 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 47/212 (22%), Positives = 107/212 (50%), Gaps = 18/212 (8%) Query: 27 YEAHVPSWGNQDDYQLVRKLGRGKYSEV----FEAINITNNERVVVKILKPVKKKKIK-- 80 +E P+ + + +++LG+G + V ++ + E V VK L+ ++ ++ Sbjct: 30 FEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDF 89 Query: 81 -REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYI---NNTDFKQLYQILTD-FDIR 135 RE++IL++L+ NI+K + L+ EY+ + D+ Q ++ D + Sbjct: 90 EREIEILKSLQH-DNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLL 148 Query: 136 FYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-YNVRVA 194 Y ++ K ++Y +K +HRD+ N++++++ ++++ D+GL + +E Y V+ Sbjct: 149 QYTSQICKGMEYLGTKRYIHRDLATRNILVENEN-RVKIGDFGLTKVLPQDKEYYKVKEP 207 Query: 195 SR---YFKGPELLVDYQMYDYSLDMWSLGCML 223 ++ PE L + + + + D+WS G +L Sbjct: 208 GESPIFWYAPESLTESK-FSVASDVWSFGVVL 238 >5B2L-A nrPDB Length = 324 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 41/148 (27%), Positives = 73/148 (49%), Gaps = 12/148 (8%) Query: 141 LLKALDYCHSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK 199 ++KAL Y K G++HRDVKP N+++D ++ +++L D+G++ ++ + Sbjct: 125 IVKALYYLKEKHGVIHRDVKPSNILLD-ERGQIKLCDFGISGRLVDSKAKTRSAGCAAYM 183 Query: 200 GPELL----VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE- 254 PE + YD D+WSLG L + + P+ + + +++ L KVL E Sbjct: 184 APERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVL---TKVLQEEPP 240 Query: 255 -LYGYLKKYHIDLDPHFNDILGQHSRKR 281 L G++ + D D L + RKR Sbjct: 241 LLPGHM-GFSGDFQSFVKDCLTKDHRKR 267 >3BEA-A nrPDB Length = 333 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 92/217 (42%), Gaps = 35/217 (16%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPV----KKKKIKREVKILE 87 +++ Q + LG G + +V EA + +V VK+LK +K+ + E+KI+ Sbjct: 45 RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMS 104 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVF-EYINNTD-----------------FKQLYQIL 129 +L NI+ L+ P LV EY D F L Sbjct: 105 HLGQHENIVNLLGAC---THGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTL 161 Query: 130 TDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY 189 + D+ + ++ + + + SK +HRDV NV++ + ++ D+GLA Y Sbjct: 162 STRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA-KIGDFGLARDIMNDSNY 220 Query: 190 NVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 223 V+ +R + PE + D +Y D+WS G +L Sbjct: 221 IVKGNARLPVKWMAPESIFDC-VYTVQSDVWSYGILL 256 >5VD3-A nrPDB Length = 311 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 94/216 (43%), Gaps = 16/216 (7%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVK-ILKPVKKKKIKR----EVKILENLRG 91 Q +Q + +LG G Y EVF+ + + VK + P + K + EV E + Sbjct: 56 QQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQ 115 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDY 147 ++L ++ L E + +Q + L + + Y+ + L AL + Sbjct: 116 HPCCVRLEQAWEE--GGILYLQTE-LCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAH 172 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 HS+G++H DVKP N+ + + + +L D+GL A V+ + PELL Sbjct: 173 LHSQGLVHLDVKPANIFLG-PRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS 231 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQL 243 Y + D++SLG + + E HG + + QL Sbjct: 232 --YGTAADVFSLGLTILEVACNME-LPHGGEGWQQL 264 >3G0E-A nrPDB Length = 336 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 60/265 (22%), Positives = 104/265 (39%), Gaps = 51/265 (19%) Query: 12 VYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEA-----INITNNERV 66 VY + L W++ + S+G + LG G + +V EA I V Sbjct: 28 VYIDPTQLPYDHKWEFPRNRLSFG--------KTLGAGAFGKVVEATAYGLIKSDAAMTV 79 Query: 67 VVKILKP----VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDF 122 VK+LKP +++ + E+K+L L NI+ L+ + ++ EY D Sbjct: 80 AVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDL 137 Query: 123 KQLYQILTDFDI---------------------RFYMYELLKALDYCHSKGIMHRDVKPH 161 + D I + Y++ K + + SK +HRD+ Sbjct: 138 LNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAAR 197 Query: 162 NVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWS 218 N+++ H + ++ D+GLA Y V+ +R + PE + + +Y + D+WS Sbjct: 198 NILLTH-GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFN-CVYTFESDVWS 255 Query: 219 LGCMLASMIFRREPFFHGQDNYDQL 243 G IF E F G Y + Sbjct: 256 YG------IFLWELFSLGSSPYPGM 274 >4NT4-A nrPDB Length = 312 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 45/162 (27%), Positives = 84/162 (51%), Gaps = 22/162 (13%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK-----REVKIL----ENL 89 ++++ +K+G G + E+ N+ NNE V +K ++P+K K + R K+L +N Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIK-MEPMKSKAPQLHLEYRFYKLLGSHADNA 71 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILT-DFDIRFYMY---ELLKAL 145 G I + T + A+V E + + L+ I F ++ + +LL + Sbjct: 72 PDGIPRIYHLGTCG---GRYNAMVLELLG-LSLEDLFNICARKFSLKTVLMIAKQLLHRI 127 Query: 146 DYCHSKGIMHRDVKPHNVMIDH----QQKKLRLIDWGLAEFY 183 +Y HS+ +++RDVKP N +I ++K + +ID+GLA+ Y Sbjct: 128 EYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEY 169 >5HVK-A nrPDB Length = 315 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 97/213 (45%), Gaps = 41/213 (19%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKPV------KKKKIKREVKILENLRGGTNIIKLI 99 LG+G + + AI +T+ E V ++K + ++ +EVK++ L N++K I Sbjct: 22 LGKGCFGQ---AIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEH-PNVLKFI 77 Query: 100 DTV-KDPVSKTPALVFEYINNTDFKQLYQILTDFDIRF-------YMYELLKALDYCHSK 151 + KD K + EYI L I+ D ++ + ++ + Y HS Sbjct: 78 GVLYKD---KRLNFITEYIKGG---TLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSM 131 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY--HPAQEYNVR-------------VASR 196 I+HR++ HN ++ + K + + D+GLA Q +R V + Sbjct: 132 NIIHRNLNSHNCLV-RENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNP 190 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR 229 Y+ PE +++ + YD +D++S G +L +I R Sbjct: 191 YWMAPE-MINGRSYDEKVDVFSFGIVLCEIIGR 222 >3IO7-A nrPDB Length = 313 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 45/198 (22%), Positives = 102/198 (51%), Gaps = 18/198 (9%) Query: 41 QLVRKLGRGKYSEV----FEAINITNNERVVVKILKPVKKKKIK---REVKILENLRGGT 93 + +++LG+G + V ++ + E V VK L+ ++ ++ RE++IL++L+ Sbjct: 31 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQH-D 89 Query: 94 NIIKLIDTVKDPVSKTPALVFEYI---NNTDFKQLYQILTD-FDIRFYMYELLKALDYCH 149 NI+K + L+ EY+ + D+ Q ++ D + Y ++ K ++Y Sbjct: 90 NIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLG 149 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-YNVRVASR---YFKGPELLV 205 +K +HRD+ N++++++ ++++ D+GL + +E Y V+ ++ PE L Sbjct: 150 TKRYIHRDLATRNILVENEN-RVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLT 208 Query: 206 DYQMYDYSLDMWSLGCML 223 + + + + D+WS G +L Sbjct: 209 ESK-FSVASDVWSFGVVL 225 >2A1A-B nrPDB Length = 284 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 56/223 (25%), Positives = 104/223 (46%), Gaps = 33/223 (14%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKL 98 D++ + +G G + +VF+A + + + V+K +K +K +REVK L L NI+ Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK-YNNEKAEREVKALAKL-DHVNIVHY 69 Query: 99 ------------IDTVKDPVSKTPALV--FEYINNTDFKQLYQIL----TDFDIRFYMYE 140 + SKT L E+ + +Q + D + ++E Sbjct: 70 NGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFE 129 Query: 141 -LLKALDYCHSKGIMHRDVKPHNV-MIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRY 197 + K +DY HSK +++RD+KP N+ ++D +Q +++ D+GL + + + RY Sbjct: 130 QITKGVDYIHSKKLINRDLKPSNIFLVDTKQ--VKIGDFGLVTSLKNDGKRTRSKGTLRY 187 Query: 198 FKGPELLVDYQMYDYSLDMWSLGCMLASMI------FRREPFF 234 PE + Q Y +D+++LG +LA ++ F FF Sbjct: 188 M-SPE-QISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFF 228 >5M07-A nrPDB Length = 276 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 40/167 (23%), Positives = 78/167 (46%), Gaps = 18/167 (10%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK------KKKIKREVKILENLRGGT 93 Y +VR LG EV+ + +K+L P +++ +RE ++ L Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFH-P 90 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQ-----LYQILTDFDIRFYMYELLKALDYC 148 +I+++ D + + +Y++ D Q +L ++ + + ALDY Sbjct: 91 HILEVHD--RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYA 148 Query: 149 HSKGIMHRDVKPHNVMIDHQQ---KKLRLIDWGLA-EFYHPAQEYNV 191 H +G++HRDV P NV++ Q +++ L D+G+A + +PA E + Sbjct: 149 HQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQPSYPAPELSA 195 >4XEY-B nrPDB Length = 408 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/195 (21%), Positives = 92/195 (47%), Gaps = 12/195 (6%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGTN 94 + D + KLG G+Y EV+E + + V VK LK ++ ++ +E +++ ++ N Sbjct: 124 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK-HPN 182 Query: 95 IIKLID-TVKDPVSKTPALVFEYINNTDF-KQLYQILTDFDIRFYM-YELLKALDYCHSK 151 +++L+ ++P Y N D+ ++ + + + YM ++ A++Y K Sbjct: 183 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 242 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDYQ 208 +HRD+ N ++ + +++ D+GL+ Y +++ + PE L Y Sbjct: 243 NFIHRDLAARNCLVG-ENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA-YN 299 Query: 209 MYDYSLDMWSLGCML 223 + D+W+ G +L Sbjct: 300 KFSIKSDVWAFGVLL 314 >2OGV-A nrPDB Length = 317 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 93/213 (43%), Gaps = 31/213 (14%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPV----KKKKIKREVKILE 87 +++ Q + LG G + +V EA + +V VK+LK +K+ + E+KI+ Sbjct: 37 RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMS 96 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVF-EYINNTDF-------------KQLYQILTDFD 133 +L NI+ L+ P LV EY D K+ + L D Sbjct: 97 HLGQHENIVNLLGAC---THGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRD 153 Query: 134 IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV 193 + + ++ + + + SK +HRDV NV++ + ++ D+GLA Y V+ Sbjct: 154 LLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA-KIGDFGLARDIMNDSNYIVKG 212 Query: 194 ASRY---FKGPELLVDYQMYDYSLDMWSLGCML 223 +R + PE + D +Y D+WS G +L Sbjct: 213 NARLPVKWMAPESIFDC-VYTVQSDVWSYGILL 244 >2PL0-A nrPDB Length = 289 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 49/231 (21%), Positives = 104/231 (45%), Gaps = 28/231 (12%) Query: 22 REYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKI 79 + +W+ E VP ++ +LV +LG G++ EV+ + +V VK LK + Sbjct: 11 KPWWEDEWEVP----RETLKLVERLGAGQFGEVWMGY-YNGHTKVAVKSLKQGSMSPDAF 65 Query: 80 KREVKILENLRGGTNIIKLIDTV-KDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYM 138 E +++ L+ +++L V ++P+ ++ EY+ N + T I+ + Sbjct: 66 LAEANLMKQLQH-QRLVRLYAVVTQEPIY----IITEYMENGSLVDFLK--TPSGIKLTI 118 Query: 139 YELL-------KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV 191 +LL + + + + +HRD++ N+++ ++ D+GLA EY Sbjct: 119 NKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLIE-DNEYTA 176 Query: 192 RVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDN 239 R +++ + PE ++Y + D+WS G +L ++ + G N Sbjct: 177 REGAKFPIKWTAPEA-INYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTN 226 >5IKW-A nrPDB Length = 310 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 45/183 (24%), Positives = 87/183 (47%), Gaps = 28/183 (15%) Query: 79 IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIR--- 135 KRE+ I++ L G NI+ +D + +S V+E + ++ + Q++ + + Sbjct: 57 CKREITIMKELSGHKNIVGYLDCAVNSISDN---VWEVLILMEYCRAGQVVNQMNKKLQT 113 Query: 136 -FYMYELLKAL-DYCHSKG--------IMHRDVKPHNVMIDHQQKKLRLIDWGLA--EFY 183 F E+L+ D C + I+HRD+K N++++ + L D+G A +F Sbjct: 114 GFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYV-LCDFGSATNKFL 172 Query: 184 HPAQE-YNV------RVASRYFKGPELLVDY--QMYDYSLDMWSLGCMLASMIFRREPFF 234 +P ++ NV + + ++ PE++ Y + D+W+LGC+L + F PF Sbjct: 173 NPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFG 232 Query: 235 HGQ 237 Q Sbjct: 233 ESQ 235 >3KRL-A nrPDB Length = 335 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 97/219 (44%), Gaps = 37/219 (16%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPV----KKKKIKREVKILE 87 +++ Q + LG G + +V EA + +V VK+LK +K+ + E+KI+ Sbjct: 45 RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMS 104 Query: 88 NLRGGTNIIKLID--TVKDPV------------------SKTPALVFEYINNTDFKQLYQ 127 +L NI+ L+ T PV + P L + Y + + ++ Sbjct: 105 HLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQ-- 162 Query: 128 ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ 187 L+ D+ + ++ + + + SK +HRDV NV++ + ++ D+GLA Sbjct: 163 -LSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA-KIGDFGLARDIMNDS 220 Query: 188 EYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 223 Y V+ +R + PE + D +Y D+WS G +L Sbjct: 221 NYIVKGNARLPVKWMAPESIFDC-VYTVQSDVWSYGILL 258 >4GS6-A nrPDB Length = 315 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 53/201 (26%), Positives = 89/201 (44%), Gaps = 26/201 (12%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDP 105 +GRG + V +A + + +I ++K E++ L + NI+KL +P Sbjct: 17 VGRGAFGVVCKA-KWRAKDVAIKQIESESERKAFIVELRQLSRVNH-PNIVKLYGACLNP 74 Query: 106 VSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYC----------HS---KG 152 V LV EY + LY +L + Y Y A+ +C HS K Sbjct: 75 V----CLVMEY---AEGGSLYNVLHGAEPLPY-YTAAHAMSWCLQCSQGVAYLHSMQPKA 126 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDY 212 ++HRD+KP N+++ L++ D+G A N A+ + PE+ + Y Sbjct: 127 LIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAA--WMAPEVF-EGSNYSE 183 Query: 213 SLDMWSLGCMLASMIFRREPF 233 D++S G +L +I RR+PF Sbjct: 184 KCDVFSWGIILWEVITRRKPF 204 >4Y83-A nrPDB Length = 332 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/194 (26%), Positives = 93/194 (47%), Gaps = 20/194 (10%) Query: 48 RGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVS 107 RG + +V+ A +I +R+ K++ PV + K +V+I R NI +L V Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLI-PVDQFK-PSDVEIQACFRH-ENIAELYGAVL--WG 137 Query: 108 KTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVM 164 +T L E + + + +F+I + +LK LD+ HSK ++H D+KP N++ Sbjct: 138 ETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIV 197 Query: 165 IDHQQKKLRLIDWGLA-----EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSL 219 K L+D+GL+ + Y P ++R + + PE+++ + + D++SL Sbjct: 198 F--MSTKAVLVDFGLSVQMTEDVYFPK---DLR-GTEIYMSPEVIL-CRGHSTKADIYSL 250 Query: 220 GCMLASMIFRREPF 233 G L M P+ Sbjct: 251 GATLIHMQTGTPPW 264 >4TPT-A nrPDB Length = 303 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 96/214 (44%), Gaps = 42/214 (19%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKPV------KKKKIKREVKILENLRGGTNIIKLI 99 LG+G + + AI +T+ V ++K + +K EVK++ +L N++K I Sbjct: 8 LGKGFFGQ---AIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSL-DHPNVLKFI 63 Query: 100 DTV-KDPVSKTPALVFEYINNTDFKQLYQILTDF----DIRFYMYELLKALDYCHSKGIM 154 + KD K L+ EYI K + + F +RF + + Y HS I+ Sbjct: 64 GVLYKD---KKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRF-AKGIASGMAYLHSMCII 119 Query: 155 HRDVKPHNVMIDHQQKKLRLIDWGLAEFY------HPAQEYNVR---------------V 193 HRD+ HN +I K + + D+GL+ P ++ + V Sbjct: 120 HRDLNSHNCLI-KLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVV 178 Query: 194 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI 227 + Y+ PE+L + + YD ++D++S G +L +I Sbjct: 179 GNPYWMAPEML-NGKSYDETVDIFSFGIVLCEII 211 >5L2Q-C nrPDB Length = 320 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 46/196 (23%), Positives = 89/196 (45%), Gaps = 41/196 (20%) Query: 129 LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE 188 L++ + Y++++ ++ H K I+HRD+K N++++ + ++ + ++ L + H E Sbjct: 150 LSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGK--HLVSE 207 Query: 189 YNV---RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR 245 ++ + S + P++L DMW+LG +L +M++ + PF YD + Sbjct: 208 GDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPF------YDSI-- 259 Query: 246 IAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKL 305 +EL+ +K E I + R VS + L+ KL Sbjct: 260 ------PQELFRKIKAA--------------------EYTIPEDGR--VSENTVCLIRKL 291 Query: 306 LRYDHQQRLTAKEAME 321 L D QQRL A + +E Sbjct: 292 LVLDPQQRLAAADVLE 307 >4JLC-A nrPDB Length = 657 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 46/235 (19%) Query: 46 LGRGKYSEVFE----------AINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNI 95 LG+G + VF A+ + NN + L+PV + RE ++L+ L NI Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNN----ISFLRPVDVQM--REFEVLKKL-NHKNI 68 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTD---------FDIRFYMYELLKALD 146 +KL ++ ++ L+ E+ LY +L + + + +++ ++ Sbjct: 69 VKLFAIEEETTTRHKVLIMEF---CPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 125 Query: 147 YCHSKGIMHRDVKPHNVM---IDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE- 202 + GI+HRD+KP N+M + Q +L D+G A +++ + + P+ Sbjct: 126 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 185 Query: 203 -----LLVDYQ-MYDYSLDMWSLGCML-----ASMIFRREPFFHGQDNYDQLVRI 246 L D+Q Y ++D+WS+G S+ FR PF + N + + +I Sbjct: 186 YERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFR--PFEGPRRNKEVMYKI 238 >4K33-A nrPDB Length = 325 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 62/265 (23%), Positives = 108/265 (40%), Gaps = 49/265 (18%) Query: 32 PSWG-NQDDYQLVRKLGRGKYSEVF--EAINITNNERVVVKILKPVKKKKIKREVKILEN 88 P W ++ L + LG G + +V EAI I + +R + VK K K L + Sbjct: 29 PKWELSRARLTLGKPLGEGAFGQVVMAEAIGI-DKDRAAKPVTVAVKMLKDDATDKDLSD 87 Query: 89 LRGGTNIIKLIDTVKDPVSKTPA--------LVFEYINNTDFKQLYQI------------ 128 L ++K+I K+ ++ A ++ EY + ++ + Sbjct: 88 LVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDT 147 Query: 129 -------LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE 181 LT D+ Y++ + ++Y S+ +HRD+ NV++ + +++ D+GLA Sbjct: 148 SKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLV-TEDNVMKIADFGLAR 206 Query: 182 FYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQD 238 H Y R + PE L D ++Y + D+WS G +L E F G Sbjct: 207 DVHNLDYYKETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLL------WEIFTLGGS 259 Query: 239 NYDQLVRIAKVLGTEELYGYLKKYH 263 Y + EEL+ LK+ H Sbjct: 260 PYPG-------IPVEELFKLLKEGH 277 >2PSQ-A nrPDB Length = 370 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 65/268 (24%), Positives = 114/268 (42%), Gaps = 55/268 (20%) Query: 32 PSWG-NQDDYQLVRKLGRGKYSEVF--EAINITNNE-----RVVVKILKPVKKKK----I 79 P W +D L + LG G + +V EA+ I ++ V VK+LK +K + Sbjct: 74 PKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDL 133 Query: 80 KREVKILENLRGGTNIIKLID--TVKDPV------------------SKTPALVFEY-IN 118 E+++++ + NII L+ T P+ + P + + Y IN Sbjct: 134 VSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIN 193 Query: 119 NTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG 178 +Q+ T D+ Y+L + ++Y S+ +HRD+ NV++ + +++ D+G Sbjct: 194 RVPEEQM----TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-TENNVMKIADFG 248 Query: 179 LAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFH 235 LA + Y R + PE L D ++Y + D+WS G ++ E F Sbjct: 249 LARDINNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMW------EIFTL 301 Query: 236 GQDNYDQLVRIAKVLGTEELYGYLKKYH 263 G Y + EEL+ LK+ H Sbjct: 302 GGSPYPG-------IPVEELFKLLKEGH 322 >3PLS-A nrPDB Length = 298 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 47/218 (21%), Positives = 96/218 (44%), Gaps = 28/218 (12%) Query: 44 RKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGG--------TNI 95 R +G+G + V+ I + + +K + + ++V+ LR G N+ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAF--LREGLLMRGLNHPNV 84 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL----TDFDIRFYMYELLKALDYCHSK 151 + LI + P P ++ Y+ + D Q + T D+ + ++ + ++Y + Sbjct: 85 LALIGIMLPP-EGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQ 143 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLA------EFYHPAQEYNVRVASRYFKGPELLV 205 +HRD+ N M+D + +++ D+GLA E+Y Q + R+ ++ L Sbjct: 144 KFVHRDLAARNCMLD-ESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTA----LE 198 Query: 206 DYQMYDYSL--DMWSLGCMLASMIFRREPFFHGQDNYD 241 Q Y ++ D+WS G +L ++ R P + D +D Sbjct: 199 SLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFD 236 >4EUU-A nrPDB Length = 319 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 46/235 (19%) Query: 46 LGRGKYSEVFE----------AINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNI 95 LG+G + VF AI + NN + L+PV + RE ++L+ L NI Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNN----ISFLRPVDVQM--REFEVLKKLNH-KNI 69 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTD---------FDIRFYMYELLKALD 146 +KL ++ ++ L+ E+ LY +L + + + +++ ++ Sbjct: 70 VKLFAIEEETTTRHKVLIMEF---CPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 126 Query: 147 YCHSKGIMHRDVKPHNVM---IDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE- 202 + GI+HR++KP N+M + Q +L D+G A +++ + + P+ Sbjct: 127 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 186 Query: 203 -----LLVDYQ-MYDYSLDMWSLGCML-----ASMIFRREPFFHGQDNYDQLVRI 246 L D+Q Y ++D+WS+G S+ FR PF + N + + +I Sbjct: 187 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--PFEGPRRNKEVMYKI 239 >6NPU-A nrPDB Length = 298 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 42/195 (21%), Positives = 92/195 (47%), Gaps = 12/195 (6%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGTN 94 + D + KLG G+Y EV+E + + V VK LK ++ ++ +E +++ ++ N Sbjct: 25 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK-HPN 83 Query: 95 IIKLID-TVKDPVSKTPALVFEYINNTDF-KQLYQILTDFDIRFYM-YELLKALDYCHSK 151 +++L+ ++P Y N D+ ++ + + + YM ++ A++Y K Sbjct: 84 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 143 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDYQ 208 +HRD+ N ++ + +++ D+GL+ Y +++ + PE L Y Sbjct: 144 NFIHRDLAARNCLVG-ENHLVKVADFGLSRL-MTGDTYTAHAGAKFPIKWTAPESLA-YN 200 Query: 209 MYDYSLDMWSLGCML 223 + D+W+ G +L Sbjct: 201 KFSIKSDVWAFGVLL 215 >2FO0-A nrPDB Length = 495 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 41/195 (21%), Positives = 92/195 (47%), Gaps = 12/195 (6%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGTN 94 + D + KLG G+Y EV+E + + V VK LK ++ ++ +E +++ ++ N Sbjct: 216 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK-HPN 274 Query: 95 IIKLID-TVKDPVSKTPALVFEYINNTDF-KQLYQILTDFDIRFYM-YELLKALDYCHSK 151 +++L+ ++P Y N D+ ++ + + + YM ++ A++Y K Sbjct: 275 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 334 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDYQ 208 +HR++ N ++ + +++ D+GL+ Y +++ + PE L Y Sbjct: 335 NFIHRNLAARNCLVG-ENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA-YN 391 Query: 209 MYDYSLDMWSLGCML 223 + D+W+ G +L Sbjct: 392 KFSIKSDVWAFGVLL 406 >4EUT-A nrPDB Length = 396 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 46/235 (19%) Query: 46 LGRGKYSEVFE----------AINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNI 95 LG+G + VF AI + NN + L+PV + RE ++L+ L NI Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNN----ISFLRPVDVQM--REFEVLKKLNH-KNI 69 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTD---------FDIRFYMYELLKALD 146 +KL ++ ++ L+ E+ LY +L + + + +++ ++ Sbjct: 70 VKLFAIEEETTTRHKVLIMEF---CPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 126 Query: 147 YCHSKGIMHRDVKPHNVM---IDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE- 202 + GI+HR++KP N+M + Q +L D+G A +++ + + P+ Sbjct: 127 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 186 Query: 203 -----LLVDYQ-MYDYSLDMWSLGCML-----ASMIFRREPFFHGQDNYDQLVRI 246 L D+Q Y ++D+WS+G S+ FR PF + N + + +I Sbjct: 187 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--PFEGPRRNKEVMYKI 239 >3UIU-A nrPDB Length = 306 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 29/102 (28%), Positives = 54/102 (52%), Gaps = 10/102 (9%) Query: 140 ELLKALDYCHSKGIMHRDVKPHNV-MIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYF 198 ++ K +DY HSK ++HRD+KP N+ ++D +Q +++ D+GL + + + Sbjct: 144 QITKGVDYIHSKKLIHRDLKPSNIFLVDTKQ--VKIGDFGLVTSLKNDGKRTRSKGTLRY 201 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMI------FRREPFF 234 PE + Q Y +D+++LG +LA ++ F FF Sbjct: 202 MSPE-QISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFF 242 >4RT7-A nrPDB Length = 415 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 30/99 (30%), Positives = 52/99 (52%), Gaps = 5/99 (5%) Query: 128 ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ 187 +LT D+ + Y++ K +++ K +HRD+ NV++ H K +++ D+GLA Sbjct: 239 VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKICDFGLARDIMSDS 297 Query: 188 EYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 223 Y VR +R + PE L + +Y D+WS G +L Sbjct: 298 NYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILL 335 >5HLW-A nrPDB Length = 299 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 47/217 (21%), Positives = 94/217 (43%), Gaps = 24/217 (11%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVK------ILENLRGGTNIIKLI 99 +GRG + V+ + N+ + + +K + + EV I+ N++ L+ Sbjct: 28 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 87 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLYQILTDF----DIRFYMYELLKALDYCHSKGIMH 155 +P +V Y+ + D + + T D+ + ++ K + Y SK +H Sbjct: 88 GICLRS-EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVH 146 Query: 156 RDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY-------- 207 RD+ N M+D ++ +++ D+GLA H + Y+V + G +L V + Sbjct: 147 RDLAARNCMLD-EKFTVKVADFGLARDMHDKEYYSVHNKT----GAKLPVKWMALESLQT 201 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLV 244 Q + D+WS G +L ++ R P + + +D V Sbjct: 202 QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITV 238 >6NT9-A nrPDB Length = 742 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 46/235 (19%) Query: 46 LGRGKYSEVFE----------AINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNI 95 LG+G + VF AI + NN + L+PV + RE ++L+ L NI Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNN----ISFLRPVDVQM--REFEVLKKL-NHKNI 67 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTD---------FDIRFYMYELLKALD 146 +KL ++ ++ L+ E+ LY +L + + + +++ ++ Sbjct: 68 VKLFAIEEETTTRHKVLIMEF---CPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 Query: 147 YCHSKGIMHRDVKPHNVM---IDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE- 202 + GI+HR++KP N+M + Q +L D+G A +++ + + P+ Sbjct: 125 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 Query: 203 -----LLVDYQ-MYDYSLDMWSLGCML-----ASMIFRREPFFHGQDNYDQLVRI 246 L D+Q Y ++D+WS+G S+ FR PF + N + + +I Sbjct: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--PFEGPRRNKEVMYKI 237 >1CSN-A nrPDB Length = 298 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 35/153 (22%), Positives = 75/153 (49%), Gaps = 12/153 (7%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRGGTNIIK 97 Y++ R++G G + +FE N+ NN++V +K +P + +++ E + + L G T I Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIK-FEPRRSDAPQLRDEYRTYKLLAGCTGIPN 70 Query: 98 LIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIR---FYMYELLKALDYCHSKGIM 154 + ++ + LV + + + L F ++ ++L + H K ++ Sbjct: 71 VYYFGQEGLHNV--LVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLV 128 Query: 155 HRDVKPHNVMIDHQQKK----LRLIDWGLAEFY 183 +RD+KP N +I K + ++D+G+ +FY Sbjct: 129 YRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFY 161 >6O8B-A nrPDB Length = 665 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 46/235 (19%) Query: 46 LGRGKYSEVFE----------AINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNI 95 LG+G + VF AI + NN + L+PV + RE ++L+ L NI Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNN----ISFLRPVDVQM--REFEVLKKL-NHKNI 75 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTD---------FDIRFYMYELLKALD 146 +KL ++ ++ L+ E+ LY +L + + + +++ ++ Sbjct: 76 VKLFAIEEETTTRHKVLIMEF---CPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 132 Query: 147 YCHSKGIMHRDVKPHNVM---IDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE- 202 + GI+HR++KP N+M + Q +L D+G A +++ + + P+ Sbjct: 133 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDM 192 Query: 203 -----LLVDYQ-MYDYSLDMWSLGCML-----ASMIFRREPFFHGQDNYDQLVRI 246 L D+Q Y ++D+WS+G S+ FR PF + N + + +I Sbjct: 193 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--PFEGPRRNKEVMYKI 245 >4XCU-A nrPDB Length = 300 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 41/149 (27%), Positives = 69/149 (46%), Gaps = 21/149 (14%) Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY----NVRVA 194 Y++ + + Y S+ +HRD+ NV++ + +++ D+GLA H Y N R+ Sbjct: 137 YQVARGMQYLESRKCIHRDLAARNVLVT-EDNVMKIADFGLARGVHHIDYYKKTSNGRLP 195 Query: 195 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE 254 ++ PE L D ++Y + D+WS G +L E F G Y + EE Sbjct: 196 VKWM-APEALFD-RVYTHQSDVWSFGILLW------EIFTLGGSPYPG-------IPVEE 240 Query: 255 LYGYLKKYH-IDLDPHFNDILGQHSRKRW 282 L+ L++ H +D PH L R+ W Sbjct: 241 LFSLLREGHRMDRPPHCPPELYGLMRECW 269 >3PPZ-A nrPDB Length = 309 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 107/223 (47%), Gaps = 29/223 (13%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-----PVKKKKIKREVKILENLRGGT 93 D + K+G G + V A + V VKIL + + REV I++ LR Sbjct: 38 DLNIKEKIGAGSFGTVHRAE--WHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRH-P 94 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL--------TDFDIRFYM-YELLKA 144 NI+ + V P + + +V EY++ LY++L D R M Y++ K Sbjct: 95 NIVLFMGAVTQPPNLS--IVTEYLSRG---SLYRLLHKSGAREQLDERRRLSMAYDVAKG 149 Query: 145 LDYCHSKG--IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVA-SRYFKGP 201 ++Y H++ I+HRD+K N+++D ++ +++ D+GL+ + A + + P Sbjct: 150 MNYLHNRNPPIVHRDLKSPNLLVD-KKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAP 208 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLV 244 E+L D + S D++S G +L + ++P+ G N Q+V Sbjct: 209 EVLRDEPSNEKS-DVYSFGVILWELATLQQPW--GNLNPAQVV 248 >1S9I-A nrPDB Length = 354 Score = 47.4 bits (111), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 49/209 (23%), Positives = 91/209 (43%), Gaps = 24/209 (11%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL----KPVKKKKIKREVKILENLRGGT 93 DD++ + +LG G V + + + + K++ KP + +I RE+++L Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 74 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--------QILTDFDIRFYMYELLKAL 145 I+ ++ E+++ Q+ +IL I +L+ L Sbjct: 75 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSI-----AVLRGL 127 Query: 146 DYCHSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL 204 Y K IMHRDVKP N++++ + +++L D+G++ + N V +R + PE L Sbjct: 128 AYLREKHQIMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMAPERL 185 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPF 233 Y D+WS+G L + R P Sbjct: 186 QGTH-YSVQSDIWSMGLSLVELAVGRYPI 213 >3DTC-A nrPDB Length = 271 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 48/208 (23%), Positives = 92/208 (44%), Gaps = 28/208 (13%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKL-----ID 100 +G G + +V+ A I + V VK + + I + + EN+R + + I Sbjct: 15 IGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTI---ENVRQEAKLFAMLKHPNII 69 Query: 101 TVKDPVSKTP--ALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKGI-- 153 ++ K P LV E+ ++ +I D + + ++ + ++Y H + I Sbjct: 70 ALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVN-WAVQIARGMNYLHDEAIVP 128 Query: 154 -MHRDVKPHNVMI-------DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV 205 +HRD+K N++I D K L++ D+GLA +H + + A + PE+ + Sbjct: 129 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWM-APEV-I 186 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPF 233 M+ D+WS G +L ++ PF Sbjct: 187 RASMFSKGSDVWSYGVLLWELLTGEVPF 214 >4UY9-A nrPDB Length = 323 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 49/209 (23%), Positives = 93/209 (44%), Gaps = 30/209 (14%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKL-----ID 100 +G G + +V+ A I + V VK + + I + + EN+R + + I Sbjct: 17 IGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTI---ENVRQEAKLFAMLKHPNII 71 Query: 101 TVKDPVSKTP--ALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKGI-- 153 ++ K P LV E+ ++ +I D + + ++ + ++Y H + I Sbjct: 72 ALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVN-WAVQIARGMNYLHDEAIVP 130 Query: 154 -MHRDVKPHNVMI-------DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY-FKGPELL 204 +HRD+K N++I D K L++ D+GLA +H + + A Y + PE+ Sbjct: 131 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH--RTTKMSAAGTYAWMAPEV- 187 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPF 233 + M+ D+WS G +L ++ PF Sbjct: 188 IRASMFSKGSDVWSYGVLLWELLTGEVPF 216 >4R7H-A nrPDB Length = 343 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/226 (23%), Positives = 93/226 (41%), Gaps = 44/226 (19%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPV----KKKKIKREVKILE 87 +++ Q + LG G + +V EA + +V VK+LK +K+ + E+KI+ Sbjct: 49 RNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMS 108 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVF-EYINNTDF------------------------ 122 +L NI+ L+ P LV EY D Sbjct: 109 HLGQHENIVNLLGAC---THGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEG 165 Query: 123 --KQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180 K+ + L D+ + ++ + + + SK +HRDV NV++ + ++ D+GLA Sbjct: 166 LDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA-KIGDFGLA 224 Query: 181 EFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 223 Y V+ +R + PE + D +Y D+WS G +L Sbjct: 225 RDIMNDSNYIVKGNARLPVKWMAPESIFD-SVYTVQSDVWSYGILL 269 >5EG3-A nrPDB Length = 334 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 61/270 (22%), Positives = 116/270 (42%), Gaps = 59/270 (21%) Query: 32 PSWG-NQDDYQLVRKLGRGKYSEVF--EAINITNNE-----RVVVKILKPVKKKK----I 79 P W +D L + LG G + +V EA+ I ++ V VK+LK +K + Sbjct: 28 PKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDL 87 Query: 80 KREVKILENLRGGTNIIKLIDTVKDPVSKTPA-LVFEYINNTDFKQLYQI---------- 128 E+++++ + NII L+ P ++ Y + + ++ + Sbjct: 88 VSEMEMMKMIGKHKNIINLLGAC---TQDGPLYVIVAYASKGNLREYLRARRPPGMELSP 144 Query: 129 ---------LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL 179 +T D+ Y+L + ++Y S+ +HRD+ NV++ + +++ D+GL Sbjct: 145 DINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV-TENNVMKIADFGL 203 Query: 180 A------EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 A +F+ + N R+ ++ PE L D ++Y + D+WS G ++ E F Sbjct: 204 ARDINNIDFFK--ETTNGRLPVKWM-APEALFD-RVYTHQSDVWSFGVLMW------EIF 253 Query: 234 FHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 G Y + EEL+ LK+ H Sbjct: 254 TLGGSPYPG-------IPVEELFKLLKEGH 276 >2HK5-A nrPDB Length = 270 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/211 (22%), Positives = 100/211 (47%), Gaps = 25/211 (11%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP--VKKKKIKREVKILENLRGGTN 94 ++ +L +KLG G++ EV+ A + +V VK +KP + + E +++ L+ Sbjct: 14 RESLKLEKKLGAGQFGEVWMA-TYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQ-HDK 71 Query: 95 IIKLIDTV-KDPV-------SKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALD 146 ++KL V K+P+ +K L F ++ KQ L DF ++ + + Sbjct: 72 LVKLHAVVTKEPIYIITEFMAKGSLLDF-LKSDEGSKQPLPKLIDFSA-----QIAEGMA 125 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPEL 203 + + +HRD++ N+++ ++ D+GLA EY R +++ + PE Sbjct: 126 FIEQRNYIHRDLRAANILVSASL-VCKIADFGLARVIE-DNEYTAREGAKFPIKWTAPE- 182 Query: 204 LVDYQMYDYSLDMWSLGCMLASMI-FRREPF 233 +++ + D+WS G +L ++ + R P+ Sbjct: 183 AINFGSFTIKSDVWSFGILLMEIVTYGRIPY 213 >4NEU-A nrPDB Length = 333 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 39/171 (22%), Positives = 83/171 (48%), Gaps = 22/171 (12%) Query: 81 REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--QILTDFDIRF-Y 137 E K++ LR + ++KL+ + + +LV EY+ + + ++ T ++ Sbjct: 71 EEAKMMNRLRH-SRVVKLLGVIIE--EGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRI 127 Query: 138 MYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA----QEYN--- 190 + E+++ + Y H KG++H+D+KP N+++D+ +++ D GLA F + +E+N Sbjct: 128 ILEIIEGMCYLHGKGVIHKDLKPENILVDNDF-HIKIADLGLASFKMWSKLNNEEHNELR 186 Query: 191 -------VRVASRYFKGPELLVDYQMYDYS-LDMWSLGCMLASMIFRREPF 233 + Y+ PE L D D++S +L ++ +EP+ Sbjct: 187 EVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPY 237 >2RIO-A nrPDB Length = 434 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 50/219 (22%), Positives = 97/219 (44%), Gaps = 59/219 (26%) Query: 138 MYELLKALDYCHSKGIMHRDVKPHNVMI--------DHQQ--KKLRLI--DWGLAEFYHP 185 + ++ + + HS I+HRD+KP N+++ D Q + LR++ D+GL + Sbjct: 121 LRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDS 180 Query: 186 AQE-----YNVRVASRYFKGPELLVDY------QMYDYSLDMWSLGCMLASMIFR-REPF 233 Q N + ++ PELL + + S+D++S+GC+ ++ + + PF Sbjct: 181 GQSSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF 240 Query: 234 FHGQDNYDQLVRIAK-VLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRH 292 D Y + I + + +E +K H +R Sbjct: 241 ---GDKYSRESNIIRGIFSLDE----MKCLH--------------------------DRS 267 Query: 293 LVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKE 331 L++ EA DL+ +++ +D +R TA + + HP F+P K+ Sbjct: 268 LIA-EATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKK 305 >6E4F-A nrPDB Length = 290 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 48/198 (24%), Positives = 91/198 (45%), Gaps = 24/198 (12%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGTNII 96 D +++LG G++ V + V +K++K + + + E K++ NL Sbjct: 32 DLTFLKELGTGQFG-VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE---- 86 Query: 97 KLIDTVKDPVSKTPALVF-EYINNTDFKQLYQILTDFDIRFYMYELLK-------ALDYC 148 KL+ + P + EY+ N L L + RF +LL+ A++Y Sbjct: 87 KLVQLYGVCTKQRPIFIITEYMANG---CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 143 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLV 205 SK +HRD+ N +++ Q +++ D+GL+ Y EY V S++ + PE+L+ Sbjct: 144 ESKQFLHRDLAARNCLVN-DQGVVKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVLM 201 Query: 206 DYQMYDYSLDMWSLGCML 223 Y + D+W+ G ++ Sbjct: 202 -YSKFSSKSDIWAFGVLM 218 >2XYN-A nrPDB Length = 292 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 43/199 (21%), Positives = 95/199 (47%), Gaps = 20/199 (10%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGTN 94 + D + KLG G+Y EV+ + + V VK LK ++ ++ +E +++ ++ N Sbjct: 31 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK-HPN 89 Query: 95 IIKLID--TVKDPVSKTPALVFEYI---NNTDFKQLY--QILTDFDIRFYMYELLKALDY 147 +++L+ T++ P +V EY+ N D+ + + +T + + ++ A++Y Sbjct: 90 LVQLLGVCTLEPPFY----IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEY 145 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELL 204 K +HRD+ N ++ + +++ D+GL+ Y +++ + PE L Sbjct: 146 LEKKNFIHRDLAARNCLVG-ENHVVKVADFGLSRL-MTGDTYTAHAGAKFPIKWTAPESL 203 Query: 205 VDYQMYDYSLDMWSLGCML 223 Y + D+W+ G +L Sbjct: 204 A-YNTFSIKSDVWAFGVLL 221 >4XI2-A nrPDB Length = 446 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 47/199 (23%), Positives = 96/199 (48%), Gaps = 26/199 (13%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGTNII 96 D +++LG G++ V + V +K+++ + + + E K++ NL ++ Sbjct: 188 DLTFLKELGTGQFG-VVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNL-SHEKLV 245 Query: 97 KL--IDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLK-------ALDY 147 +L + T + P+ ++ EY+ N L L + RF +LL+ A++Y Sbjct: 246 QLYGVCTKQRPI----FIITEYMANG---CLLNYLREMRHRFQTQQLLEMCKDVCEAMEY 298 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELL 204 SK +HRD+ N +++ Q +++ D+GL+ Y EY V S++ + PE+L Sbjct: 299 LESKQFLHRDLAARNCLVN-DQGVVKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVL 356 Query: 205 VDYQMYDYSLDMWSLGCML 223 + Y + D+W+ G ++ Sbjct: 357 M-YSKFSSKSDIWAFGVLM 374 >5CEK-A nrPDB Length = 263 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 47/197 (23%), Positives = 84/197 (42%), Gaps = 47/197 (23%) Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQK-KLRLIDWGLAEFYHPAQEYNVRVASRY- 197 +++ A+ +CH I+ D+K + +++ +LRL E H + + ++ ++ Sbjct: 108 QIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESL---EDTHIMKGEDDALSDKHG 164 Query: 198 ---FKGPELLVDYQMYD-YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTE 253 + PE+L Y + D+WSLG ML +++ R PF Sbjct: 165 CPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPF-------------------- 204 Query: 254 ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR 313 H +D S+ R F E+ +SP+A L+ LLR + +R Sbjct: 205 ---------------HDSDPSALFSKIRRGQFCIPEH---ISPKARCLIRSLLRREPSER 246 Query: 314 LTAKEAMEHPYFYPVVK 330 LTA E + HP+F V++ Sbjct: 247 LTAPEILLHPWFESVLE 263 >3MDY-A nrPDB Length = 337 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 97/210 (46%), Gaps = 34/210 (16%) Query: 41 QLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILEN-LRGGTNIIKLI 99 Q+V+++G+G+Y EV+ + E+V VK+ ++ RE +I + L NI+ I Sbjct: 40 QMVKQIGKGRYGEVW--MGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFI 97 Query: 100 DT-VKDPVSKTPA-LVFEYINNTDFKQLYQIL--TDFDIRFYM---YELLKALDYCHSK- 151 +K S T L+ +Y N LY L T D + + Y + L + H++ Sbjct: 98 AADIKGTGSWTQLYLITDYHEN---GSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEI 154 Query: 152 -------GIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEY----NVRVASRYFK 199 I HRD+K N+++ + + D GLA +F E N RV ++ + Sbjct: 155 FSTQGKPAIAHRDLKSKNILV-KKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYM 213 Query: 200 GPELLVD------YQMYDYSLDMWSLGCML 223 PE+L + +Q Y + DM+S G +L Sbjct: 214 PPEVLDESLNRNHFQSYIMA-DMYSFGLIL 242 >6DC0-A nrPDB Length = 292 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 47/197 (23%), Positives = 84/197 (42%), Gaps = 47/197 (23%) Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQK-KLRLIDWGLAEFYHPAQEYNVRVASRY- 197 +++ A+ +CH I+ D+K + +++ +LRL E H + + ++ ++ Sbjct: 105 QIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESL---EDTHIMKGEDDALSDKHG 161 Query: 198 ---FKGPELLVDYQMYD-YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTE 253 + PE+L Y + D+WSLG ML +++ R PF Sbjct: 162 CPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPF-------------------- 201 Query: 254 ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR 313 H +D S+ R F E+ +SP+A L+ LLR + +R Sbjct: 202 ---------------HDSDPSALFSKIRRGQFCIPEH---ISPKARCLIRSLLRREPSER 243 Query: 314 LTAKEAMEHPYFYPVVK 330 LTA E + HP+F V++ Sbjct: 244 LTAPEILLHPWFESVLE 260 >4AT3-A nrPDB Length = 299 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 52/229 (22%), Positives = 101/229 (44%), Gaps = 39/229 (17%) Query: 42 LVRKLGRGKYSEVF--EAINITNNER---VVVKILKPVK---KKKIKREVKILENLRGGT 93 L R+LG G + +VF E N+ + V VK LK +K RE ++L NL+ Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQH-E 75 Query: 94 NIIKL--IDTVKDPVSKTPALVFEYINNTDFKQLYQI----------------LTDFDIR 135 +I+K + DP+ +VFEY+ + D + + LT + Sbjct: 76 HIVKFYGVCVEGDPL----IMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQML 131 Query: 136 FYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV---- 191 ++ + Y S+ +HRD+ N ++ + +++ D+G++ + Y V Sbjct: 132 HIAQQIAAGMVYLASQHFVHRDLATRNCLVG-ENLLVKIGDFGMSRDVYSTDYYRVGGHT 190 Query: 192 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRREPFFHGQDN 239 + R+ P + Y+ + D+WSLG +L + + ++P++ +N Sbjct: 191 MLPIRWM--PPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 237 >3V5Q-A nrPDB Length = 297 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 55/229 (24%), Positives = 98/229 (42%), Gaps = 38/229 (16%) Query: 39 DYQLVRKLGRGKYSEVF--EAINITNNER---VVVKILKP---VKKKKIKREVKILENLR 90 D L R+LG G + +VF E N++ + V VK LK +K +RE ++L NL+ Sbjct: 16 DIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQ 75 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-------ILTDFDIRFYMYEL-- 141 +I+K D +VFEY+ + D + + IL D R EL Sbjct: 76 -HEHIVKFYGVCGD--GDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGL 132 Query: 142 ----------LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV 191 + Y S+ +HRD+ N ++ +++ D+G++ + Y V Sbjct: 133 SQMLHIASQIASGMVYLASQHFVHRDLATRNCLVG-ANLLVKIGDFGMSRDVYSTDYYRV 191 Query: 192 ----RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRREPFFH 235 + R+ P + Y+ + D+WS G +L + + ++P+F Sbjct: 192 GGHTMLPIRWM--PPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQ 238 >4XHH-A nrPDB Length = 403 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 33/158 (20%), Positives = 76/158 (48%), Gaps = 24/158 (15%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRGGTNI-- 95 +++ RK+G G + +++ N+ + E V ++ L+ ++ + ++ E ++ + L GG I Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIR-LESIRSRHPQLDYESRVYKYLSGGVGIPF 67 Query: 96 IKLID-------TVKDPVSKTPALVFEYINNT-DFKQLYQILTDFDIRFYMYELLKALDY 147 I+ V D + + +F Y + FK + + +++ + Y Sbjct: 68 IRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIML---------ALQMICRVQY 118 Query: 148 CHSKGIMHRDVKPHNVM--IDHQQKKLRLIDWGLAEFY 183 H + +HRD+KP N + + + + +ID+GL++ Y Sbjct: 119 IHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKY 156 >4CRS-A nrPDB Length = 341 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 72/310 (23%), Positives = 125/310 (40%), Gaps = 66/310 (21%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNI 95 N D++ L RG + +V A NE +K LK K + R+ +++L I Sbjct: 10 NLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALK--KGDIVARDE--VDSLMCEKRI 65 Query: 96 IKLIDTVKDP----------VSKTPALVFEYINNTDFKQLYQILTDF----DIRFYMYEL 141 + +++V+ P + V EY D + I TD FY + Sbjct: 66 FETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDL--MMHIHTDVFSEPRAVFYAACV 123 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKG 200 + L Y H I++RD+K + ++ + +++ D+GL E + + F Sbjct: 124 VLGLQYLHEHKIVYRDLK-LDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLA 182 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK 260 PE+L + Y ++D W LG ++ M+ P F G D EE++ Sbjct: 183 PEVLTETS-YTRAVDWWGLGVLIYEMLVGESP-FPGDDE-------------EEVF---- 223 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE-- 318 D ND + R+ F+ S EA+ ++ +LLR + ++RL A E Sbjct: 224 ------DSIVNDEV------RYPRFL--------STEAISIMRRLLRRNPERRLGASEKD 263 Query: 319 ---AMEHPYF 325 +HP+F Sbjct: 264 AEDVKKHPFF 273 >3MY0-A nrPDB Length = 305 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 65/276 (23%), Positives = 110/276 (39%), Gaps = 42/276 (15%) Query: 42 LVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILEN-LRGGTNIIKLI- 99 LV +G+G+Y EV+ + + E V VKI ++ RE +I L NI+ I Sbjct: 12 LVECVGKGRYGEVWRG--LWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA 69 Query: 100 -DTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYCHSK---- 151 D S L+ Y + DF Q + +R + L + H + Sbjct: 70 SDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAAC-GLAHLHVEIFGT 128 Query: 152 ----GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY-----NVRVASRYFKGPE 202 I HRD K NV++ + + D GLA + +Y N RV ++ + PE Sbjct: 129 QGKPAIAHRDFKSRNVLVKSNLQCC-IADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPE 187 Query: 203 LLVD------YQMYDYSLDMWSLGCMLASMIFR----------REPFFHGQDNYDQLVRI 246 +L + ++ Y ++ D+W+ G +L + R R PF+ N + Sbjct: 188 VLDEQIRTDCFESYKWT-DIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDM 246 Query: 247 AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRW 282 KV+ ++ + + DP + L Q R+ W Sbjct: 247 KKVVCVDQQTPTIPN-RLAADPVLSG-LAQMMRECW 280 >4Y93-A nrPDB Length = 446 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 46/199 (23%), Positives = 94/199 (47%), Gaps = 26/199 (13%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGTNII 96 D +++LG G++ V + V +K++K + + + E K++ NL ++ Sbjct: 189 DLTFLKELGTGQFG-VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL-SHEKLV 246 Query: 97 KL--IDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLK-------ALDY 147 +L + T + P+ ++ EY+ N L L + RF +LL+ A++Y Sbjct: 247 QLYGVCTKQRPI----FIITEYMANG---CLLNYLREMRHRFQTQQLLEMCKDVCEAMEY 299 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELL 204 SK +HRD+ N +++ Q +++ D+G+ Y EY S++ + PE+L Sbjct: 300 LESKQFLHRDLAARNCLVN-DQGVVKVSDFGMTR-YVLDDEYTSSTGSKFPVKWASPEVL 357 Query: 205 VDYQMYDYSLDMWSLGCML 223 + Y + D+W+ G ++ Sbjct: 358 M-YSKFSSKSDIWAFGVLM 375 >4XHL-A nrPDB Length = 394 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 33/158 (20%), Positives = 74/158 (46%), Gaps = 24/158 (15%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRGGTNI-- 95 +++ RK+G G + +++ N+ + E V ++ L+ ++ + ++ E ++ L GG I Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIR-LESIRSRHPQLDYESRVYRYLSGGVGIPF 67 Query: 96 IKLID-------TVKDPVSKTPALVFEYINNT-DFKQLYQILTDFDIRFYMYELLKALDY 147 I+ V D + + +F Y + FK + + ++ + Y Sbjct: 68 IRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIML---------ALQMFCRIQY 118 Query: 148 CHSKGIMHRDVKPHNVM--IDHQQKKLRLIDWGLAEFY 183 H + +HRD+KP N + + + + +ID+GL++ Y Sbjct: 119 IHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKY 156 >1AD5-A nrPDB Length = 438 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 51/231 (22%), Positives = 109/231 (47%), Gaps = 40/231 (17%) Query: 18 SLRSREYWDYEA-HVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP--V 74 S + ++ W+ +A +P ++ +L +KLG G++ EV+ A + +V VK +KP + Sbjct: 165 SSKPQKPWEKDAWEIP----RESLKLEKKLGAGQFGEVWMA-TYNKHTKVAVKTMKPGSM 219 Query: 75 KKKKIKREVKILENLRGGTNIIKLIDTV-KDPV-------SKTPALVFEYINNTDFKQLY 126 + E +++ L+ ++KL V K+P+ +K L F ++ KQ Sbjct: 220 SVEAFLAEANVMKTLQ-HDKLVKLHAVVTKEPIYIITEFMAKGSLLDF-LKSDEGSKQPL 277 Query: 127 QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA 186 L DF ++ + + + + +HRD++ N+++ ++ D+GLA Sbjct: 278 PKLIDFSA-----QIAEGMAFIEQRNYIHRDLRAANILVSASL-VCKIADFGLA------ 325 Query: 187 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRREPF 233 RV +++ + PE +++ + D+WS G +L ++ + R P+ Sbjct: 326 -----RVGAKFPIKWTAPE-AINFGSFTIKSDVWSFGILLMEIVTYGRIPY 370 >4XLV-A nrPDB Length = 328 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 58/263 (22%), Positives = 113/263 (42%), Gaps = 36/263 (13%) Query: 7 GSRARVYAEVNS--LRSREYWDYEAHVP-SWG-NQDDYQLVRKLGRGKYSEVFE--AINI 60 G ++A N L + + + +VP W +++ L+R+LG+G + V+E A +I Sbjct: 4 GPLGPLFASSNPEYLSASDVFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDI 63 Query: 61 TNNE---RVVVKILKPVKKKKIKREVKILEN---LRGGT--NIIKLIDTVKDPVSKTPAL 112 E RV VK + + ++ ++ L ++G T ++++L+ V + + Sbjct: 64 IKGEAETRVAVKTVN--ESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSK--GQPTLV 119 Query: 113 VFEYINNTDFKQLYQIL-------------TDFDIRFYMYELLKALDYCHSKGIMHRDVK 159 V E + + D K + L T ++ E+ + Y ++K +HRD+ Sbjct: 120 VMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLA 179 Query: 160 PHNVMIDHQQKKLRLIDWGLAEFYHPAQEY---NVRVASRYFKGPELLVDYQMYDYSLDM 216 N M+ H +++ D+G+ + Y + + PE L D ++ S DM Sbjct: 180 ARNCMVAH-DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKD-GVFTTSSDM 237 Query: 217 WSLGCMLASMIFRREPFFHGQDN 239 WS G +L + E + G N Sbjct: 238 WSFGVVLWEITSLAEQPYQGLSN 260 >4LRM-A nrPDB Length = 334 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 44/218 (20%), Positives = 98/218 (44%), Gaps = 29/218 (13%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI--------LKPVKKKKIKREVKILEN 88 + +++ ++ LG G + V++ + I E+V + + P K+I E ++ + Sbjct: 18 ETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMAS 77 Query: 89 LRGGTNI-------IKLIDTVKDPVSKTP-ALVFEYINNTDFKQLYQILTDFDIRFYMYE 140 + N I L TV+ P + +Y+ Q L ++ + + Sbjct: 78 VDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCV-----Q 132 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNV---RVASR 196 + K ++Y + ++HRD+ NV++ Q +++ D+GLA+ + EY+ +V + Sbjct: 133 IAKGMNYLEDRRLVHRDLAARNVLVKTPQ-HVKITDFGLAKLLGAEEKEYHAEGGKVPIK 191 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRREPF 233 + +L +++Y + D+WS G + M F +P+ Sbjct: 192 WMALESIL--HRIYTHQSDVWSYGVTVWELMTFGSKPY 227 >3C1X-A nrPDB Length = 373 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 43/215 (20%), Positives = 91/215 (42%), Gaps = 20/215 (9%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVK------ILENLRGGTNIIKLI 99 +GRG + V+ + N+ + + +K + + EV I+ N++ L+ Sbjct: 97 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 156 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLYQILTDF----DIRFYMYELLKALDYCHSKGIMH 155 +P +V Y+ + D + + T D+ + ++ K + + SK +H Sbjct: 157 GICLRS-EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKKFVH 215 Query: 156 RDVKPHNVMIDHQQKKLRLIDWGLA------EFYHPAQEYNVRVASRYFKGPELLVDYQM 209 RD+ N M+D ++ +++ D+GLA EF + ++ ++ L Q Sbjct: 216 RDLAARNCMLD-EKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESL--QTQK 272 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLV 244 + D+WS G +L ++ R P + + +D V Sbjct: 273 FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITV 307 >4UYA-A nrPDB Length = 340 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/220 (21%), Positives = 94/220 (42%), Gaps = 42/220 (19%) Query: 41 QLVRKLGRGKYSEVFEAINITNNERVVVKILK-------PVKKKKIKREVKILENLRGGT 93 +L +G G + +V+ A + V VK + + ++RE ++ LR Sbjct: 29 ELKELIGAGGFGQVYRAT--WQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRH-P 85 Query: 94 NIIKLIDTVKDPVSKTP--ALVFEYINNTDFKQLY-------QILTDFDIRFYMYELLKA 144 NII+L + + P LV E+ + +L ++ + ++ + Sbjct: 86 NIIEL----RGVCLQQPHLCLVLEFARGGALNRALAGRRIPPHVLVNWAV-----QIARG 136 Query: 145 LDYCHSKG---IMHRDVKPHNVMI-------DHQQKKLRLIDWGLAEFYHPAQEYNVRVA 194 + Y H + I+HRD+K N+++ D K L++ D+GLA +H + + A Sbjct: 137 MLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWH--RTTKMATA 194 Query: 195 SRY-FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 Y + PE ++ ++ D+WS G +L ++ P+ Sbjct: 195 GAYAWMAPE-VIKSSLFSKGSDIWSYGVLLWELLTGEVPY 233 >3SOC-A nrPDB Length = 322 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 96/213 (45%), Gaps = 29/213 (13%) Query: 41 QLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI---KREVKILENLRGGTNIIK 97 QL+ RG++ V++A + NE V VKI P++ K+ + EV L ++ NI++ Sbjct: 27 QLLEVKARGRFGCVWKAQLL--NEYVAVKIF-PIQDKQSWQNEYEVYSLPGMKH-ENILQ 82 Query: 98 LIDTVKDPVS-------------KTPALVFEYINNTDFKQLYQILTDFDIRF-YMYELLK 143 I K S K F N + +L I Y++E + Sbjct: 83 FIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIP 142 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA---EFYHPAQEYNVRVASRYFKG 200 L H I HRD+K NV++ + + D+GLA E A + + +V +R + Sbjct: 143 GLKDGHKPAISHRDIKSKNVLLKNNLTAC-IADFGLALKFEAGKSAGDTHGQVGTRRYMA 201 Query: 201 PELL---VDYQMYDY-SLDMWSLGCMLASMIFR 229 PE+L +++Q + +DM+++G +L + R Sbjct: 202 PEVLEGAINFQRDAFLRIDMYAMGLVLWELASR 234 >4CI6-B nrPDB Length = 643 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 4/72 (5%) Query: 134 IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV 193 I+F + LL ++ GI+H D+KP NV+ D + +ID GL H + Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGL----HSRSGEQPKG 213 Query: 194 ASRYFKGPELLV 205 + FK PEL V Sbjct: 214 FTESFKAPELGV 225 >4IX6-A nrPDB Length = 350 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 45/211 (21%), Positives = 77/211 (36%), Gaps = 44/211 (20%) Query: 138 MYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKK-LRLIDWGLAEFYHPAQEY------N 190 M ELL +L H G++HRDVKP N++ + L+LID G A P E + Sbjct: 149 MRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETLNYYPGD 208 Query: 191 VRVASRYFKGPELLV------------DYQMYDY----SLDMWSLGCMLASMIFRREPFF 234 RY K EL + ++++ D WS GC++ + Sbjct: 209 GPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQL-------- 260 Query: 235 HGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLV 294 +V + G E K D++ + G++ + + Sbjct: 261 -------AVVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDANGG---- 309 Query: 295 SPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 DL +L+ + R + + A+ H +F Sbjct: 310 --AGWDLCQRLMEAERDARASCEAALSHAFF 338 >2QLU-A nrPDB Length = 314 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 101/217 (46%), Gaps = 36/217 (16%) Query: 41 QLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKIL-------ENL---- 89 QL+ RG++ V++A + N+ V VKI K+ + E +I ENL Sbjct: 18 QLLEIKARGRFGCVWKAQLM--NDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFI 75 Query: 90 ---RGGTNI---IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLK 143 + G+N+ + LI D S T L I + + + ++ R Y L + Sbjct: 76 AAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMS----RGLSY-LHE 130 Query: 144 ALDYCHSKG----IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ---EYNVRVASR 196 + +C +G I HRD K NV++ + L D+GLA + P + + + +V +R Sbjct: 131 DVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAV-LADFGLAVRFEPGKPPGDTHGQVGTR 189 Query: 197 YFKGPELL---VDYQMYDY-SLDMWSLGCMLASMIFR 229 + PE+L +++Q + +DM+++G +L ++ R Sbjct: 190 RYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSR 226 >3QD2-B nrPDB Length = 332 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 25/102 (24%), Positives = 53/102 (51%), Gaps = 15/102 (14%) Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE----------- 188 ++ +A+++ HSKG+MHRD+KP N+ +++ D+GL +E Sbjct: 172 QIAEAVEFLHSKGLMHRDLKPSNIFFT-MDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAY 230 Query: 189 --YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 228 + +V ++ + PE + Y + +D++SLG +L +++ Sbjct: 231 ATHTGQVGTKLYMSPE-QIHGNNYSHKVDIFSLGLILFELLY 271 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 17/55 (30%), Positives = 32/55 (58%), Gaps = 4/55 (7%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKIL----KPVKKKKIKREVKILENL 89 D++ ++ +GRG + VFEA N ++ +K + + + ++K+ REVK L L Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKL 61 >5X18-A nrPDB Length = 295 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 41/165 (24%), Positives = 77/165 (46%), Gaps = 36/165 (21%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRGGTNI-- 95 Y++ +K+G G + +FE N+ N V +K +P K + +++ E K + L G NI Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIK-FEPRKTEAPQLRDEYKTYKILNGTPNIPY 67 Query: 96 -----------IKLIDTVKDPVSKTPAL--VFEYINNTDFKQLYQILTDFDIRFYMYELL 142 I +ID + P+L +F++ + + T + M L+ Sbjct: 68 AYYFGQEGLHNILVIDLL------GPSLEDLFDWCGRK-----FSVKTVVQVAVQMITLI 116 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQK----KLRLIDWGLAEFY 183 + L H+ +++RD+KP N +I + + LID+G+A+ Y Sbjct: 117 EDL---HAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQY 158 >4OTD-A nrPDB Length = 341 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 66/294 (22%), Positives = 119/294 (40%), Gaps = 57/294 (19%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIK 97 +D++ + LGRG + +V + + E +K LK K + R+ +E+L I+ Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALK--KGDIVARDE--VESLMCEKRILA 67 Query: 98 LIDTVKDP-------VSKTP---ALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKAL 145 + + P +TP V EY D + ++ FY ++ L Sbjct: 68 AVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGL 127 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELL 204 + H I++RD+K + ++ + +++ D+GL E + + F PE+L Sbjct: 128 QFLHEHKIVYRDLK-LDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 186 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 D Y ++D W LG +L M+ P F G D EE++ Sbjct: 187 TDTS-YTRAVDWWGLGVLLYEMLVGESP-FPGDDE-------------EEVF-------- 223 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE 318 D ND R+ F+ S EA+ ++ +LLR + ++RL + E Sbjct: 224 --DSIVND------EVRYPRFL--------SAEAIGIMRRLLRRNPERRLGSSE 261 >3QUP-A nrPDB Length = 323 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 47/230 (20%), Positives = 94/230 (40%), Gaps = 29/230 (12%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGT--- 93 + + L R LG+G++ V EA + + VK+ + K I I E LR Sbjct: 22 EQQFTLGRMLGKGEFGSVREA-QLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMK 80 Query: 94 -----NIIKLIDTVKDPVSK----TPALVFEYINNTDFKQL----------YQILTDFDI 134 ++ KL+ +K P ++ ++ + D + + + Sbjct: 81 EFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLV 140 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVA 194 RF M ++ ++Y S+ +HRD+ N M+ + + + D+GL+ + Y A Sbjct: 141 RF-MVDIACGMEYLSSRNFIHRDLAARNCML-AEDMTVCVADFGLSRKIYSGDYYRQGCA 198 Query: 195 SRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYD 241 S+ + E L D +Y D+W+ G + ++ R + + G +N + Sbjct: 199 SKLPVKWLALESLAD-NLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAE 247 >2WTK-B nrPDB Length = 373 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 33/115 (28%), Positives = 54/115 (46%), Gaps = 12/115 (10%) Query: 129 LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQK--------KLRLIDWGLA 180 + + I + + +LKALDY H G +HR VK +++I K L +I G Sbjct: 109 MNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQR 168 Query: 181 E-FYHPAQEYNVRVASRYFKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRREPF 233 + H +Y+V+V + PE+L + Q YD D++S+G + PF Sbjct: 169 QRVVHDFPKYSVKVLP--WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPF 221 >3VHK-A nrPDB Length = 368 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 22/90 (24%), Positives = 50/90 (55%), Gaps = 5/90 (5%) Query: 137 YMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASR 196 Y +++ K +++ S+ +HRD+ N+++ ++ +++ D+GLA + +Y + +R Sbjct: 205 YSFQVAKGMEFLASRKCIHRDLAARNILLS-EKNVVKICDFGLARDIYKDPDYVRKGDAR 263 Query: 197 Y---FKGPELLVDYQMYDYSLDMWSLGCML 223 + PE + D ++Y D+WS G +L Sbjct: 264 LPLKWMAPETIFD-RVYTIQSDVWSFGVLL 292 >5GNK-A nrPDB Length = 297 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 43/216 (19%), Positives = 98/216 (45%), Gaps = 26/216 (12%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI--------LKPVKKKKIKREVKILE 87 + +++ ++ LG G + V++ + I E+V + + P K+I E ++ Sbjct: 17 KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMA 76 Query: 88 NLRGGTNI----IKLIDTVKDPVSKTP-ALVFEYINNTDFKQLYQILTDFDIRFYMYELL 142 ++ I L TV+ + P + +Y+ Q L ++ + ++ Sbjct: 77 SVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCV-----QIA 131 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNV---RVASRYF 198 K ++Y + ++HRD+ NV++ Q +++ D+GLA+ + EY+ +V ++ Sbjct: 132 KGMNYLEDRRLVHRDLAARNVLVKTPQ-HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM 190 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRREPF 233 +L +++Y + D+WS G + M F +P+ Sbjct: 191 ALESIL--HRIYTHQSDVWSYGVTVWELMTFGSKPY 224 >3LZB-A nrPDB Length = 327 Score = 40.8 bits (94), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 43/216 (19%), Positives = 97/216 (44%), Gaps = 26/216 (12%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI--------LKPVKKKKIKREVKILE 87 + +++ ++ LG G + V++ + I E+V + + P K+I E ++ Sbjct: 13 KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMA 72 Query: 88 NLRGGTNI----IKLIDTVKDPVSKTP-ALVFEYINNTDFKQLYQILTDFDIRFYMYELL 142 ++ I L TV+ P + +Y+ Q L ++ + ++ Sbjct: 73 SVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCV-----QIA 127 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNV---RVASRYF 198 K ++Y + ++HRD+ NV++ Q +++ D+GLA+ + EY+ +V ++ Sbjct: 128 KGMNYLEDRRLVHRDLAARNVLVKTPQ-HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM 186 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRREPF 233 +L +++Y + D+WS G + M F +P+ Sbjct: 187 ALESIL--HRIYTHQSDVWSYGVTVWELMTFGSKPY 220 >3HNG-A nrPDB Length = 360 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 23/98 (23%), Positives = 53/98 (54%), Gaps = 5/98 (5%) Query: 129 LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE 188 +T D+ Y +++ + +++ S+ +HRD+ N+++ + +++ D+GLA + + Sbjct: 196 ITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILL-SENNVVKICDFGLARDIYKNPD 254 Query: 189 YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCML 223 Y + +R + PE + D ++Y D+WS G +L Sbjct: 255 YVRKGDTRLPLKWMAPESIFD-KIYSTKSDVWSYGVLL 291 >2Y4I-B nrPDB Length = 319 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/148 (27%), Positives = 66/148 (44%), Gaps = 27/148 (18%) Query: 46 LGRGKYSEVFE-------AINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKL 98 +G+G++ +V+ AI + + ER LK KREV R N++ Sbjct: 41 IGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLK-----AFKREVMAYRQTRH-ENVVLF 94 Query: 99 IDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI-------RFYMYELLKALDYCHSK 151 + P P L + + LY ++ D I R E++K + Y H+K Sbjct: 95 MGACMSP----PHLAI-ITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK 149 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGL 179 GI+H+D+K NV D+ K+ + D+GL Sbjct: 150 GILHKDLKSKNVFYDN--GKVVITDFGL 175 >2H34-A nrPDB Length = 309 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 47/205 (22%), Positives = 91/205 (44%), Gaps = 16/205 (7%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVKILENLRGGT 93 Y+L R +GRG +V+EA + V +K++ PV + +++RE + L+ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQE-P 94 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHS 150 +++ + D + + + IN D + + L + ++ ALD H+ Sbjct: 95 HVVPIHDFGE--IDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHA 152 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ--EYNVRVASRYFKGPELLVDYQ 208 G HRDVKP N+++ L+D+G+A + + V + Y+ PE + Sbjct: 153 AGATHRDVKPENILVSADDFAY-LVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESH 211 Query: 209 MYDYSLDMWSLGCMLASMIFRREPF 233 Y D+++L C+L + P+ Sbjct: 212 AT-YRADIYALTCVLYECLTGSPPY 235 >4JRN-A nrPDB Length = 372 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 58/280 (20%), Positives = 103/280 (36%), Gaps = 66/280 (23%) Query: 42 LVR--KLGRGKYSEVFEAINITNNERVVVKILKPVKKKK--------------------- 78 LVR LG G ++ V+EA ++ NE + VK+ K+ Sbjct: 70 LVRGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAK 129 Query: 79 ------------IKREVKILENLRGGTNIIKLIDTVKDP------------VSKTPALVF 114 + +V +LE T ++ + T P +SK + VF Sbjct: 130 TAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVF 189 Query: 115 --EYINNTDFKQLYQILTDFDIRFYMY-ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKK 171 +N ++F + +R Y+ + +K + ++GI+H D+KP N ++ + + Sbjct: 190 GDASVNKSEFGLV--------VRMYLSSQAIKLVANVQAQGIVHTDIKPANFLL-LKDGR 240 Query: 172 LRLIDWGLAEFYHPAQEYNVRVASRYFKGPE--LLVDYQMYDYSLDMWSLGCMLASMIFR 229 L L D+G Y + + ++ PE Y + D W LG L + + Sbjct: 241 LFLGDFGT---YRINNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCK 297 Query: 230 REPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 P D + A T EL L + ++ DP Sbjct: 298 ERP--TPADGIWDYLHFADCPSTPELVQDLIRSLLNRDPQ 335 >5AMN-A nrPDB Length = 299 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 45/211 (21%), Positives = 90/211 (42%), Gaps = 30/211 (14%) Query: 42 LVRKLGRGKYSEVFEAINITNNER-----VVVKILK----PVKKKKIKREVKILENLRGG 92 L + LG G++ +V +A R V VK+LK P + + + E +L+ + Sbjct: 27 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNH- 85 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-------------ILTDFDIRFYMY 139 ++IKL L+ EY + + LT D+ + + Sbjct: 86 PHVIKLYGACSQ--DGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAW 143 Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY-- 197 ++ + + Y ++HRD+ N+++ + +K+++ D+GL+ + Y R R Sbjct: 144 QISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV 202 Query: 198 -FKGPELLVDYQMYDYSLDMWSLGCMLASMI 227 + E L D+ +Y D+WS G +L ++ Sbjct: 203 KWMAIESLFDH-IYTTQSDVWSFGVLLWEIV 232 >4P5Q-A nrPDB Length = 361 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 89/209 (42%), Gaps = 27/209 (12%) Query: 46 LGRGKYSEVFEA---INITNNERVVVKILKPVKKKKIKREVKILENLRGG---TNIIKLI 99 +G G++ EV + V +K LK +K +R+ ++ G NII+L Sbjct: 41 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLE 100 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELL-------KALDYCHSKG 152 V SK +V EY+ N L L D +F + +L+ + Y G Sbjct: 101 GVVTK--SKPVMIVTEYMEN---GSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMG 155 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH--PAQEYNVR---VASRYFKGPELLVDY 207 +HRD+ N++I+ ++ D+GL+ P Y R + R+ PE + Y Sbjct: 156 YVHRDLAARNILINSNL-VCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW-TSPEAIA-Y 212 Query: 208 QMYDYSLDMWSLGCML-ASMIFRREPFFH 235 + + + D+WS G +L M + P++ Sbjct: 213 RKFTSASDVWSYGIVLWEVMSYGERPYWE 241 >5WNL-A nrPDB Length = 342 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/218 (17%), Positives = 108/218 (49%), Gaps = 20/218 (9%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKILKPV-----KKKKIKREVKILENLRGGTNIIKLI 99 K+G G + +V++ ++ + +K + ++ ++ E K +E + I+ + Sbjct: 27 KVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKF-RYILPVY 85 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLYQI-LTDFDIRF-YMYELLKALDY--CHSKGIMH 155 ++PV LV EY+ ++L +D+RF ++E +++ C S ++H Sbjct: 86 GICQEPV----GLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLH 141 Query: 156 RDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY----FKGPELLVD-YQMY 210 ++KP N+++D +++ D+GLA+ + +++ + + + PE + + +++ Sbjct: 142 LNLKPANILLD-AHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLF 200 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 D D++S ++ ++ +++PF ++ ++++ K Sbjct: 201 DTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVK 238 >1BYG-A nrPDB Length = 278 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 41/205 (20%), Positives = 94/205 (45%), Gaps = 15/205 (7%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-PVKKKKIKREVKILENLRGGTN 94 N + +L++ +G+G++ +V + +V VK +K + E ++ LR +N Sbjct: 19 NMKELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRH-SN 75 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDF-----KQLYQILTDFDIRFYMYELLKALDYCH 149 +++L+ + + +V EY+ + +L + + ++ +A++Y Sbjct: 76 LVQLLGVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 134 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 +HRD+ NV++ + ++ D+GL + Q+ ++ ++ PE L + + Sbjct: 135 GNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTG-KLPVKW-TAPEALREKKF 191 Query: 210 YDYSLDMWSLGCMLASM-IFRREPF 233 S D+WS G +L + F R P+ Sbjct: 192 STKS-DVWSFGILLWEIYSFGRVPY 215 >3BBT-B nrPDB Length = 328 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 56/263 (21%), Positives = 114/263 (43%), Gaps = 33/263 (12%) Query: 43 VRKLGRGKYSEVFEAINITNNERV----VVKILK----PVKKKKIKREVKILENLRGGTN 94 V+ LG G + V++ I + E V +KIL P + E I+ ++ + Sbjct: 20 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASM-DHPH 78 Query: 95 IIKLIDTVKDPVSKTP------ALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYC 148 +++L+ P + + EY++ Q+L ++ + ++ K + Y Sbjct: 79 LVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCV-----QIAKGMMYL 133 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP-AQEYNVRVASRYFKGPEL-LVD 206 + ++HRD+ NV++ +++ D+GLA +EYN K L + Sbjct: 134 EERRLVHRDLAARNVLV-KSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIH 192 Query: 207 YQMYDYSLDMWSLGCMLAS-MIFRREPF--FHGQDNYDQLVRIAKV----LGTEELYGYL 259 Y+ + + D+WS G + M F +P+ ++ D L + ++ + T ++Y + Sbjct: 193 YRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVM 252 Query: 260 -KKYHIDLD--PHFNDILGQHSR 279 K + ID D P F ++ + SR Sbjct: 253 VKCWMIDADSRPKFKELAAEFSR 275 >4AZW-A nrPDB Length = 471 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/104 (26%), Positives = 49/104 (47%), Gaps = 3/104 (2%) Query: 75 KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI 134 K ++ E+K L G + ++ ++ +++ LV E + + + D Sbjct: 284 NKHELHNEIKFLTQPPAGFDAPAVLAHGEN--AQSGWLVMEKLPGRLLSDMLAAGEEIDR 341 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG 178 + LL++L KG H DV+P NVM+D +Q RLID+G Sbjct: 342 EKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHA-RLIDFG 384 >4YFF-A nrPDB Length = 311 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/163 (23%), Positives = 73/163 (44%), Gaps = 11/163 (6%) Query: 81 REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQILTDFDIR---F 136 REV IL L I + + DP A+V +YI+ F L++ D++ Sbjct: 89 REVSILCQLNHPCVIQFVGACLNDP--SQFAIVTQYISGGSLFSLLHEQKRILDLQSKLI 146 Query: 137 YMYELLKALDYCH--SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV--R 192 ++ K ++Y H ++ I+HRD+ HN+++ ++ + D+G + F E N+ + Sbjct: 147 IAVDVAKGMEYLHNLTQPIIHRDLNSHNILL-YEDGHAVVADFGESRFLQSLDEDNMTKQ 205 Query: 193 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFH 235 + + PE+ Y D++S L ++ PF H Sbjct: 206 PGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAH 248 >1K9A-A nrPDB Length = 450 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/205 (20%), Positives = 94/205 (45%), Gaps = 15/205 (7%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-PVKKKKIKREVKILENLRGGTN 94 N + +L++ +G+G++ +V + +V VK +K + E ++ LR +N Sbjct: 191 NMKELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRH-SN 247 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDF-----KQLYQILTDFDIRFYMYELLKALDYCH 149 +++L+ + + +V EY+ + +L + + ++ +A++Y Sbjct: 248 LVQLLGVIVEEKGGL-YIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 +HRD+ NV++ + ++ D+GL + Q+ ++ ++ PE L + + Sbjct: 307 GNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTG-KLPVKW-TAPEALREKKF 363 Query: 210 YDYSLDMWSLGCMLASMI-FRREPF 233 S D+WS G +L + F R P+ Sbjct: 364 STKS-DVWSFGILLWEIYSFGRVPY 387 >5U6B-A nrPDB Length = 307 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 50/244 (20%), Positives = 99/244 (40%), Gaps = 41/244 (16%) Query: 42 LVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGT-------- 93 L + LG G++ V E N + ++K+ K I ++ + L Sbjct: 27 LGKTLGEGEFGAVMEGQ--LNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHP 84 Query: 94 NIIKLIDTVKDPVSK----TPALVFEYINNTDFKQ--LYQILTDFDIRF-------YMYE 140 N+++LI + P ++ ++ + D LY L D + +M + Sbjct: 85 NVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMAD 144 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY-NVRVASRYFK 199 + ++Y +K +HRD+ N M+ ++ + + D+GL++ + Y R+A K Sbjct: 145 IASGMEYLSTKRFIHRDLAARNCML-NENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVK 203 Query: 200 --GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 E L D ++Y D+WS G + + R + + G +N E+Y Sbjct: 204 WIAIESLAD-RVYTSKSDVWSFGVTMWEIATRGQTPYPGVEN-------------SEIYD 249 Query: 258 YLKK 261 YL++ Sbjct: 250 YLRQ 253 >5FM2-A nrPDB Length = 355 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 24/102 (23%), Positives = 52/102 (50%), Gaps = 5/102 (4%) Query: 129 LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE 188 LT D+ + +++ + + Y ++HRD+ N+++ + +K+++ D+GL+ + Sbjct: 188 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEEDS 246 Query: 189 YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMI 227 Y R R + E L D+ +Y D+WS G +L ++ Sbjct: 247 YVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIV 287 >5AR8-A nrPDB Length = 326 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 38/154 (24%), Positives = 79/154 (51%), Gaps = 18/154 (11%) Query: 43 VRKLGRGKYSEVFEAINITNNERVVVK---ILKPV---KKKKIKREVKILENLRGGTNII 96 +R L RG V A + +V VK I P+ ++K + RE +IL R + I+ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARF-SYIL 95 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD-----IRF-YMYELLKALDYCH- 149 ++ +P + +V EY+ N +L T++ +RF ++E+ ++Y H Sbjct: 96 PILGICNEP--EFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHN 153 Query: 150 -SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF 182 + ++H D+K N+++D+ + +++ D+GL+++ Sbjct: 154 MTPPLLHHDLKTQNILLDN-EFHVKIADFGLSKW 186 >1LUF-A nrPDB Length = 343 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 46/227 (20%), Positives = 89/227 (39%), Gaps = 46/227 (20%) Query: 37 QDDYQLVRKLGRGKYSEVFEA-----INITNNERVVVKILKPVKKKKI----KREVKILE 87 +++ + VR +G G + VF+A + V VK+LK + +RE ++ Sbjct: 46 RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMA 105 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL----------TDFDIRFY 137 NI+KL+ V K L+FEY+ D + + + +D R Sbjct: 106 EF-DNPNIVKLLGVCA--VGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRAR 162 Query: 138 MY-----------------ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180 + ++ + Y + +HRD+ N ++ + +++ D+GL+ Sbjct: 163 VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVG-ENMVVKIADFGLS 221 Query: 181 EFYHPAQEY----NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 223 + A Y N + R+ P + Y Y D+W+ G +L Sbjct: 222 RNIYSADYYKADGNDAIPIRWM--PPESIFYNRYTTESDVWAYGVVL 266 >5XD6-A nrPDB Length = 305 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 49/218 (22%), Positives = 90/218 (41%), Gaps = 26/218 (11%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILENLRGGTNI 95 D+Y +G G Y VF I + + + +K L K+ ++ +V ++ LR N+ Sbjct: 22 DNYGSKSLIGEGSYGRVFYGI-LKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQ-ENV 79 Query: 96 IKLID-TVKDPVSKTPALVFEYINNTDFKQLYQ------------ILTDFDIRFYMYELL 142 + L+ V P+ L +EY N + +L+ Sbjct: 80 VALLGYCVDGPLR---VLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAA 136 Query: 143 KALDYCHSKG---IMHRDVKPHNVMI-DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY- 197 + L+Y H K ++HRD+K NV++ D K+ D A+ ++ RV + Sbjct: 137 RGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFG 196 Query: 198 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFH 235 + PE + + S D++S G +L ++ R+P H Sbjct: 197 YHAPEYAMTGTLSTKS-DVYSFGVVLLELLTGRKPVDH 233 >3QGY-A nrPDB Length = 286 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 38/196 (19%), Positives = 89/196 (45%), Gaps = 18/196 (9%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGTNI 95 + V+++G G++ V + N ++V +K +K + + E +++ L + Sbjct: 27 SELTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIKEGSMSEDDFIEEAEVMMKL----SH 81 Query: 96 IKLIDTVKDPVSKTP-ALVFEYINN---TDFKQLYQILTDFDIRFYM-YELLKALDYCHS 150 KL+ + + P LVFE++ + +D+ + + L + M ++ + + Y Sbjct: 82 PKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEE 141 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDY 207 ++HRD+ N ++ Q +++ D+G+ F Q Y +++ + PE+ + Sbjct: 142 ACVIHRDLAARNCLVGENQ-VIKVSDFGMTRFVLDDQ-YTSSTGTKFPVKWASPEVF-SF 198 Query: 208 QMYDYSLDMWSLGCML 223 Y D+WS G ++ Sbjct: 199 SRYSSKSDVWSFGVLM 214 >4AZV-A nrPDB Length = 569 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 27/104 (25%), Positives = 49/104 (47%), Gaps = 3/104 (2%) Query: 75 KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI 134 K ++ E+K L G + ++ ++ +++ LV E + + + D Sbjct: 284 NKYELHNEIKFLTQPPAGFDAPAVLAHGEN--AQSGWLVMEKLPGRLLSDMLAAGEEIDR 341 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG 178 + LL++L +G H DV+P NVM+D +Q RLID+G Sbjct: 342 EKILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHA-RLIDFG 384 >2R2P-A nrPDB Length = 295 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 48/201 (23%), Positives = 85/201 (42%), Gaps = 24/201 (11%) Query: 44 RKLGRGKYSEVFEAINITNNER---VVVKILKPVKKKKIKREVKILENLRGG---TNIIK 97 R +G G++ EV +R V +K LK +K +R+ ++ G NII Sbjct: 28 RVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIH 87 Query: 98 LIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELL-------KALDYCHS 150 L V SK +V EY+ N L L D +F + +L+ + Y Sbjct: 88 LEGVVTK--SKPVMIVTEYMEN---GSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSD 142 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH--PAQEYNVRVASRYFK--GPELLVD 206 G +HRD+ N++I+ ++ D+GL+ P Y R + PE + Sbjct: 143 MGYVHRDLAARNILINSNL-VCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA- 200 Query: 207 YQMYDYSLDMWSLGCMLASMI 227 ++ + + D+WS G ++ ++ Sbjct: 201 FRKFTSASDVWSYGIVMWEVV 221 >3PP0-A nrPDB Length = 338 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 59/283 (20%), Positives = 124/283 (43%), Gaps = 29/283 (10%) Query: 43 VRKLGRGKYSEVFEAINITNNERV----VVKILK----PVKKKKIKREVKILENLRGGTN 94 V+ LG G + V++ I I + E V +K+L+ P K+I E ++ + G Sbjct: 22 VKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGV-GSPY 80 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTD-FKQLYQILTDFDIRFYMYELLKALDYCHSKGI 153 + +L+ + + Y D ++ L D+ + ++ K + Y + Sbjct: 81 VSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRL 140 Query: 154 MHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNV---RVASRYFKGPELLVDYQM 209 +HRD+ NV++ +++ D+GLA + EY+ +V ++ +L + Sbjct: 141 VHRDLAARNVLV-KSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESIL--RRR 197 Query: 210 YDYSLDMWSLGCMLAS-MIFRREPF--FHGQDNYDQLVRIAKV----LGTEELYGYL-KK 261 + + D+WS G + M F +P+ ++ D L + ++ + T ++Y + K Sbjct: 198 FTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKC 257 Query: 262 YHIDLD--PHFNDILGQHSR--KRWENFIHSENRHLVSPEALD 300 + ID + P F +++ + SR + + F+ +N L LD Sbjct: 258 WMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLD 300 >6G4J-A nrPDB Length = 315 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 38/153 (24%), Positives = 67/153 (43%), Gaps = 17/153 (11%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNI 95 N + Y L ++LG+G V+ A T++ V +K+ I EV +L++ ++ Sbjct: 24 NGNTYTLRKQLGKGANGIVYLAE--TSDGHVALKVSD--DSLSITSEVNVLKSFSKAQSV 79 Query: 96 I---KLIDT----VKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYELLKAL 145 DT + +K EYI L + ++D I M +LL +L Sbjct: 80 TMGPSFFDTDDAYIPSANTKVSFYAMEYIKGP---LLLKYVSDKGAEWIPVLMIQLLSSL 136 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG 178 H +G + D+KP N+++ ++R ID G Sbjct: 137 SVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >2VWV-A nrPDB Length = 302 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 59/300 (19%), Positives = 113/300 (37%), Gaps = 41/300 (13%) Query: 46 LGRGKYSEVFEAINITNNER---VVVKILKPVKKKKIKREVKILENLRGG---TNIIKLI 99 +G G++ EV ++ V +K LK ++ +RE ++ G NII+L Sbjct: 24 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLE 83 Query: 100 DTVKDPVSKTPALVF-EYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCHSKGIM 154 V + P ++ E++ N ++ T + + + + Y + Sbjct: 84 GVVTN---SMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYV 140 Query: 155 HRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK------GPELLVDYQ 208 HRD+ N++++ ++ D+GL+ F +S K PE + ++ Sbjct: 141 HRDLAARNILVNSNLV-CKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIA-FR 198 Query: 209 MYDYSLDMWSLG-CMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 + + D WS G M M F P++ N D + I + Y + Sbjct: 199 KFTSASDAWSYGIVMWEVMSFGERPYWD-MSNQDVINAIEQ------------DYRLPPP 245 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE--AMEHPYF 325 P L Q W+ ++ R P+ + LDK++R ++ A+E HP Sbjct: 246 PDCPTSLHQLMLDCWQKDRNARPRF---PQVVSALDKMIRNPASLKIVARENGGASHPLL 302 >3KUL-B nrPDB Length = 325 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 54/250 (21%), Positives = 102/250 (40%), Gaps = 27/250 (10%) Query: 66 VVVKILKPVKKKKIKREVKILENLRGG---TNIIKLIDTVKDPVSKTPALVFEYINNTDF 122 V +K LK ++ +R+ ++ G NII+L V + +V EY+ N Sbjct: 80 VAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTR--GRLAMIVTEYMEN--- 134 Query: 123 KQLYQILTDFDIRFYMYELL-------KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLI 175 L L D +F + +L+ + Y G +HRD+ NV++D ++ Sbjct: 135 GSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVD-SNLVCKVS 193 Query: 176 DWGLAEFYH--PAQEYNV---RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRR 230 D+GL+ P Y ++ R+ PE + ++ + + D+WS G ++ ++ Sbjct: 194 DFGLSRVLEDDPDAAYTTTGGKIPIRW-TAPEAIA-FRTFSSASDVWSFGVVMWEVLAYG 251 Query: 231 EPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH-IDLDPHFNDILGQHSRKRWENFIHSE 289 E + N D + + + G H + LD D + R R+ + Sbjct: 252 ERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKD---RAQRPRFSQIVSVL 308 Query: 290 NRHLVSPEAL 299 + + SPE+L Sbjct: 309 DALIRSPESL 318 >5WNO-A nrPDB Length = 330 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 43/205 (20%), Positives = 91/205 (44%), Gaps = 14/205 (6%) Query: 41 QLVRKLGRGKYSEVFEAINITNNER-----VVVKILKPVKKK--KIKREVKILENLRGGT 93 +L +KLG G + VF I + V +K+ + + + ++ E + LR Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRH-D 83 Query: 94 NIIKLID-TVKDPVSKTPALVFEYINNTDFKQLY-QILTDFDIRFYMYELLKALDYCHSK 151 N++K+I + D K + N +F +L+ + L + Y Y++ + Y + Sbjct: 84 NLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQ 143 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY-HPAQEYNVRVASRYFKGPEL-LVDYQM 209 ++HRD+ NV++ + + + D+GL++ H A ++ K + + Sbjct: 144 RVVHRDLATRNVLV-KKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHC 202 Query: 210 YDYSLDMWSLGCMLASMI-FRREPF 233 Y ++ D+W+ G +I F + P+ Sbjct: 203 YTHASDVWAFGVTCWEIITFGQSPY 227 >5VO2-A nrPDB Length = 300 Score = 37.0 bits (84), Expect = 0.012, Method: Compositional matrix adjust. Identities = 45/207 (21%), Positives = 86/207 (41%), Gaps = 46/207 (22%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDP 105 +G G VF + + E V VK ++ +K+ IK K+ NII T K Sbjct: 20 VGSGAQGAVF--LGRFHGEEVAVKKVRDLKETDIKHLRKLKH-----PNII----TFKGV 68 Query: 106 VSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKA-------------------LD 146 ++ P Y IL +F + +YE+L+A ++ Sbjct: 69 CTQAPC--------------YCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMN 114 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVD 206 Y H I+HRD+K N++I + +++ D+G ++ + + PE++ + Sbjct: 115 YLHLHKIIHRDLKSPNMLITYDD-VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRN 173 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPF 233 + + +D+WS G +L ++ P+ Sbjct: 174 EPVSE-KVDIWSFGVVLWELLTGEIPY 199 >2QKW-B nrPDB Length = 321 Score = 35.8 bits (81), Expect = 0.026, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 49/94 (52%), Gaps = 11/94 (11%) Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG-- 200 + L Y H++ I+HRDVK N+++D + ++ D+G+++ E + S KG Sbjct: 150 RGLHYLHTRAIIHRDVKSINILLD-ENFVPKITDFGISK---KGTELDQTHLSTVVKGTL 205 Query: 201 ----PELLVDYQMYDYSLDMWSLGCMLASMIFRR 230 PE + ++ + S D++S G +L ++ R Sbjct: 206 GYIDPEYFIKGRLTEKS-DVYSFGVVLFEVLCAR 238 >3G2F-A nrPDB Length = 336 Score = 35.4 bits (80), Expect = 0.033, Method: Compositional matrix adjust. Identities = 53/232 (22%), Positives = 93/232 (40%), Gaps = 37/232 (15%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNER-VVVKILKPVKKKKIKREVKILE-NLRGGTNI 95 D+ +L+ +GRG+Y V++ + +ER V VK+ ++ E I L NI Sbjct: 13 DNLKLLELIGRGRYGAVYKG---SLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNI 69 Query: 96 IKLI---DTVKDPVSKTPALVFEYINNTDFKQLYQILTD---FDIRFYMYELLKALDYCH 149 + I + V LV EY N + + T R + + + L Y H Sbjct: 70 ARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRL-AHSVTRGLAYLH 128 Query: 150 SK---------GIMHRDVKPHNVMIDHQQKKLRLIDWGLA------EFYHPAQEYNV--- 191 ++ I HRD+ NV++ + + + D+GL+ P +E N Sbjct: 129 TELPRGDHYKPAISHRDLNSRNVLVKNDGTCV-ISDFGLSMRLTGNRLVRPGEEDNAAIS 187 Query: 192 RVASRYFKGPELLV------DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQ 237 V + + PE+L D + +DM++LG + + R F G+ Sbjct: 188 EVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGE 239 >3UIM-A nrPDB Length = 326 Score = 34.7 bits (78), Expect = 0.061, Method: Compositional matrix adjust. Identities = 51/206 (24%), Positives = 95/206 (46%), Gaps = 26/206 (12%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGGTNIIKLIDT 101 LGRG + +V++ + + V VK LK + + + + EV+++ ++ N+++L Sbjct: 38 LGRGGFGKVYKG-RLADGTLVAVKRLKEERTQGGELQFQTEVEMI-SMAVHRNLLRLRGF 95 Query: 102 VKDPVSKTPALVFEYINNTDFKQLY------QILTDFDIRFYMY-----ELLKALDYCHS 150 P + LV+ Y+ N Q D+ R + L D+C Sbjct: 96 CMTPTERL--LVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDP 153 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG---PELLVDY 207 K I+HRDVK N+++D + + + + D+GLA+ ++ +V A R G PE L Sbjct: 154 K-IIHRDVKAANILLDEEFEAV-VGDFGLAKLMD-YKDTHVTTAVRGTIGHIAPEYLSTG 210 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPF 233 + + + D++ G ML +I + F Sbjct: 211 KSSEKT-DVFGYGVMLLELITGQRAF 235 >3DKO-A nrPDB Length = 318 Score = 34.7 bits (78), Expect = 0.072, Method: Compositional matrix adjust. Identities = 47/213 (22%), Positives = 90/213 (42%), Gaps = 27/213 (12%) Query: 41 QLVRKLGRGKYSEVFEAINITNNER---VVVKILKPVKKKKIKREVKILENLRGG---TN 94 ++ R +G G++ EV +R V +K LK +K +R+ ++ G N Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPN 105 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELL-------KALDY 147 ++ L V K +V E++ N L L D +F + +L+ + Y Sbjct: 106 VVHLEGVVTR--GKPVMIVIEFMENG---ALDAFLRKHDGQFTVIQLVGMLRGIAAGMRY 160 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH--PAQEYNV---RVASRYFKGPE 202 G +HRD+ N++++ ++ D+GL+ P Y ++ R+ PE Sbjct: 161 LADMGYVHRDLAARNILVN-SNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRW-TAPE 218 Query: 203 LLVDYQMYDYSLDMWSLG-CMLASMIFRREPFF 234 + Y+ + + D+WS G M M + P++ Sbjct: 219 -AIQYRKFTSASDVWSYGIVMWEVMSYGERPYW 250 >1U59-A nrPDB Length = 287 Score = 34.3 bits (77), Expect = 0.077, Method: Compositional matrix adjust. Identities = 40/204 (19%), Positives = 94/204 (46%), Gaps = 21/204 (10%) Query: 45 KLGRGKYSEVFEAINITNNER--VVVKILKPVKKK----KIKREVKILENLRGGTNIIKL 98 +LG G + V + + ++ V +K+LK +K ++ RE +I+ L I++L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRL 75 Query: 99 IDTVKDPVSKTPALVFEYINNTDFKQLY----QILTDFDIRFYMYELLKALDYCHSKGIM 154 I + ++ LV E + + + ++ ++++ + Y K + Sbjct: 76 IGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 132 Query: 155 HRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-YNVRVASRY---FKGPELLVDYQMY 210 HRD+ NV++ ++ ++ D+GL++ Y R A ++ + PE ++++ + Sbjct: 133 HRDLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINFRKF 190 Query: 211 DYSLDMWSLG-CMLASMIFRREPF 233 D+WS G M ++ + ++P+ Sbjct: 191 SSRSDVWSYGVTMWEALSYGQKPY 214 >5CLR-A nrPDB Length = 451 Score = 34.3 bits (77), Expect = 0.080, Method: Compositional matrix adjust. Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 26/99 (26%) Query: 103 KDPVSKTPALVFEYINNTDFKQLYQILTDF----DIRFY------------MYELLKAL- 145 KD +SK LV + N Q++ ILT F D+ Y +E+L + Sbjct: 126 KDTLSKLGRLVGTFFNEQ--TQVHYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMI 183 Query: 146 DYCHSK------GIMHRDVKPHNVMIDHQQKKLRLIDWG 178 CH G++HRD+KP N+M+D + L+D+G Sbjct: 184 SVCHQVKQFHELGLIHRDLKPGNIMLDADM-QCHLVDFG 221 >1FVR-A nrPDB Length = 327 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 23/96 (23%), Positives = 47/96 (48%), Gaps = 12/96 (12%) Query: 137 YMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV----- 191 + ++ + +DY K +HRD+ N+++ + ++ D+GL+ QE V Sbjct: 147 FAADVARGMDYLSQKQFIHRDLAARNILVG-ENYVAKIADFGLSR----GQEVYVKKTMG 201 Query: 192 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI 227 R+ R+ L +Y +Y + D+WS G +L ++ Sbjct: 202 RLPVRWMAIESL--NYSVYTTNSDVWSYGVLLWEIV 235 >3ZZW-A nrPDB Length = 289 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 61/288 (21%), Positives = 118/288 (40%), Gaps = 54/288 (18%) Query: 41 QLVRKLGRGKYSEV-----FEAINITNNERVVVKILKPVKKKKIKREVKILENLRG---G 92 + + +LG ++ +V F + V +K LK + ++ E + LR Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQH 71 Query: 93 TNIIKLIDTV-KD-PVSKTPALVFEYINNTDF-------------------KQLYQILTD 131 N++ L+ V KD P+S ++F Y ++ D + + L Sbjct: 72 PNVVCLLGVVTKDQPLS----MIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEP 127 Query: 132 FDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY-- 189 D + ++ ++Y S ++H+D+ NV++ + + +++ D GL + A Y Sbjct: 128 PDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLV-YDKLNVKISDLGLFREVYAADYYKL 186 Query: 190 --NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYD--QLVR 245 N + R+ PE ++ Y + D+WS G +L + + G N D +++R Sbjct: 187 LGNSLLPIRWM-APEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIR 244 Query: 246 IAKVLGT-EELYGYLKKYHIDL-------DPHFNDILGQHSRKR-WEN 284 +VL ++ ++ I+ P F DI HSR R W N Sbjct: 245 NRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDI---HSRLRAWGN 289 >2OZO-A nrPDB Length = 613 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 39/204 (19%), Positives = 94/204 (46%), Gaps = 21/204 (10%) Query: 45 KLGRGKYSEVFEAINITNNER--VVVKILKPVKKK----KIKREVKILENLRGGTNIIKL 98 +LG G + V + + ++ V +K+LK +K ++ RE +I+ L I++L Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRL 401 Query: 99 IDTVKDPVSKTPALVFEYINNTDFKQLY----QILTDFDIRFYMYELLKALDYCHSKGIM 154 I + ++ LV E + + + ++ ++++ + Y K + Sbjct: 402 IGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 Query: 155 HRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-YNVRVASRY---FKGPELLVDYQMY 210 HR++ NV++ ++ ++ D+GL++ Y R A ++ + PE ++++ + Sbjct: 459 HRNLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINFRKF 516 Query: 211 DYSLDMWSLG-CMLASMIFRREPF 233 D+WS G M ++ + ++P+ Sbjct: 517 SSRSDVWSYGVTMWEALSYGQKPY 540 >4FL3-A nrPDB Length = 635 Score = 32.7 bits (73), Expect = 0.21, Method: Compositional matrix adjust. Identities = 29/118 (24%), Positives = 53/118 (44%), Gaps = 16/118 (13%) Query: 129 LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA------EF 182 + D +I ++++ + Y +HRD+ NV++ Q ++ D+GL+ E Sbjct: 466 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADEN 524 Query: 183 YHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240 Y+ AQ + Y PE ++Y + D+WS G ++ E F +GQ Y Sbjct: 525 YYKAQTHGKWPVKWY--APE-CINYYKFSSKSDVWSFGVLMW------EAFSYGQKPY 573 >5UIU-A nrPDB Length = 323 Score = 32.7 bits (73), Expect = 0.23, Method: Compositional matrix adjust. Identities = 44/200 (22%), Positives = 88/200 (44%), Gaps = 26/200 (13%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKILKPVK-------KKKIKREVKILENLRGGTNIIK 97 K+G G + V++ NN V VK L + K++ +E+K++ + N+++ Sbjct: 54 KMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQH-ENLVE 110 Query: 98 LIDTVKDPVSKTPALVFEYINNTDFKQLYQIL-----TDFDIRFYMYE-LLKALDYCHSK 151 L+ D LV+ Y+ N L + +R + + +++ H Sbjct: 111 LLGFSSD--GDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN 168 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLA----EFYHPAQEYNVRVASRYFKGPELLVDY 207 +HRD+K N+++D + ++ D+GLA +F + V + + PE L Sbjct: 169 HHIHRDIKSANILLD-EAFTAKISDFGLARASEKFAQTVMTSRI-VGTTAYMAPEALRG- 225 Query: 208 QMYDYSLDMWSLGCMLASMI 227 ++ S D++S G +L +I Sbjct: 226 EITPKS-DIYSFGVVLLEII 244 >5C26-A nrPDB Length = 299 Score = 32.3 bits (72), Expect = 0.31, Method: Compositional matrix adjust. Identities = 29/118 (24%), Positives = 53/118 (44%), Gaps = 16/118 (13%) Query: 129 LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA------EF 182 + D +I ++++ + Y +HRD+ NV++ Q ++ D+GL+ E Sbjct: 124 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADEN 182 Query: 183 YHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240 Y+ AQ + Y PE ++Y + D+WS G ++ E F +GQ Y Sbjct: 183 YYKAQTHGKWPVKWY--APE-CINYYKFSSKSDVWSFGVLMW------EAFSYGQKPY 231 >4O1O-A nrPDB Length = 717 Score = 32.0 bits (71), Expect = 0.37, Method: Compositional matrix adjust. Identities = 13/38 (34%), Positives = 21/38 (55%) Query: 131 DFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQ 168 D R + L KA+ H G H+D++P N++ID + Sbjct: 441 DESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSK 478 >5VC6-A nrPDB Length = 289 Score = 32.0 bits (71), Expect = 0.38, Method: Compositional matrix adjust. Identities = 27/139 (19%), Positives = 62/139 (44%), Gaps = 14/139 (10%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVK-----ILKPVKKKKIKREVKILENLRGGT 93 ++ + K+G G++ VF+ + + +K + V ++ REV L + Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDF----KQLYQILTDF---DIRFYMYELLKALD 146 ++++ + + EY N + Y+I++ F +++ + ++ + L Sbjct: 72 HVVRYFSAWAE--DDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLR 129 Query: 147 YCHSKGIMHRDVKPHNVMI 165 Y HS ++H D+KP N+ I Sbjct: 130 YIHSMSLVHMDIKPSNIFI 148 >6J6I-B nrPDB Length = 351 Score = 32.0 bits (71), Expect = 0.43, Method: Compositional matrix adjust. Identities = 21/68 (30%), Positives = 35/68 (51%), Gaps = 11/68 (16%) Query: 110 PALVFEYINNTDFKQLYQILTD-------FDIRFYM-YELLKALDYCHS---KGIMHRDV 158 P LVFE+ + Q ++ + + +R + E+ A+ Y H+ K I+HRDV Sbjct: 133 PVLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDV 192 Query: 159 KPHNVMID 166 KP +V +D Sbjct: 193 KPMHVFLD 200 >2RSV-A nrPDB Length = 403 Score = 31.2 bits (69), Expect = 0.61, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 29/46 (63%), Gaps = 1/46 (2%) Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQ-KKLRLIDWGLAEFYHP 185 +L L+Y H +H D+K N++++++ ++ L+D+GLA Y P Sbjct: 168 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 213 >5U6C-A nrPDB Length = 315 Score = 31.2 bits (69), Expect = 0.64, Method: Compositional matrix adjust. Identities = 46/223 (20%), Positives = 89/223 (39%), Gaps = 26/223 (11%) Query: 42 LVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGT-------- 93 L + LG G++ V E N+ + +K+ K + +I E L Sbjct: 40 LGKILGEGEFGSVMEG-NLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHP 98 Query: 94 NIIKLIDTVKDPVSKT---PALVFEYINNTDFKQ--LYQILTDFDIRFYMYELLK----- 143 N+++L+ + S+ P ++ ++ D LY L + LLK Sbjct: 99 NVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDI 158 Query: 144 --ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY-NVRVASRYFK- 199 ++Y ++ +HRD+ N M+ + + D+GL++ + Y R+A K Sbjct: 159 ALGMEYLSNRNFLHRDLAARNCML-RDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKW 217 Query: 200 -GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYD 241 E L D ++Y D+W+ G + + R + G N++ Sbjct: 218 IAIESLAD-RVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHE 259 >2LAV-A nrPDB Length = 361 Score = 31.2 bits (69), Expect = 0.67, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 29/46 (63%), Gaps = 1/46 (2%) Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQ-KKLRLIDWGLAEFYHP 185 +L L+Y H +H D+K N++++++ ++ L+D+GLA Y P Sbjct: 161 ILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCP 206 >4I94-A nrPDB Length = 300 Score = 31.2 bits (69), Expect = 0.73, Method: Compositional matrix adjust. Identities = 24/88 (27%), Positives = 45/88 (51%), Gaps = 6/88 (6%) Query: 141 LLKALDYCHSKG-IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK 199 + +AL+YC SKG ++ D+ + V+ D RL +GL + + Y+ +A F Sbjct: 136 IAQALEYCTSKGRALYHDLNAYRVLFDDDANP-RLSCFGLMKNSRDGKSYSTNLA---FT 191 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMI 227 PE L ++ S+ ++S G +L ++ Sbjct: 192 PPEYLRTGRVTPESV-IYSFGTLLLDLL 218 >5LPV-A nrPDB Length = 296 Score = 31.2 bits (69), Expect = 0.78, Method: Compositional matrix adjust. Identities = 46/207 (22%), Positives = 89/207 (42%), Gaps = 30/207 (14%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRG--GTNIIKLIDTVK 103 +G G + +V++AI + + V +K L V + + + +E + N++ L+ K Sbjct: 25 IGSGGFGDVYKAI-LKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCK 83 Query: 104 DPVSKTPALVFEYINNTDFKQLYQILTD----------FDIRFYMYELLKALDYCH---S 150 V LV+E++ + L +L D R + L + H S Sbjct: 84 --VGDERLLVYEFMK---YGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCS 138 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY---NVRVASRYFKGPELLVDY 207 I+HRD+K NV++D + + R+ D+G+A + + + + PE Y Sbjct: 139 PHIIHRDMKSSNVLLD-ENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY---Y 194 Query: 208 QMYDYSL--DMWSLGCMLASMIFRREP 232 Q + S D++S G +L ++ + P Sbjct: 195 QSFRCSTKGDVYSYGVVLLELLTGKRP 221 >3SXS-A nrPDB Length = 268 Score = 31.2 bits (69), Expect = 0.79, Method: Compositional matrix adjust. Identities = 25/106 (23%), Positives = 49/106 (46%), Gaps = 12/106 (11%) Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY- 197 Y++ + + + S +HRD+ N ++D + +++ D+G+ + Q Y V +++ Sbjct: 111 YDVCEGMAFLESHQFIHRDLAARNCLVD-RDLCVKVSDFGMTRYVLDDQ-YVSSVGTKFP 168 Query: 198 --FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYD 241 + PE+ Y Y D+W+ G I E F G+ YD Sbjct: 169 VKWSAPEVF-HYFKYSSKSDVWAFG------ILMWEVFSLGKMPYD 207 >5LPZ-A nrPDB Length = 332 Score = 30.8 bits (68), Expect = 0.87, Method: Compositional matrix adjust. Identities = 46/207 (22%), Positives = 89/207 (42%), Gaps = 30/207 (14%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRG--GTNIIKLIDTVK 103 +G G + +V++AI + + V +K L V + + + +E + N++ L+ K Sbjct: 25 IGSGGFGDVYKAI-LKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCK 83 Query: 104 DPVSKTPALVFEYINNTDFKQLYQILTD----------FDIRFYMYELLKALDYCH---S 150 V LV+E++ + L +L D R + L + H S Sbjct: 84 --VGDERLLVYEFMK---YGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCS 138 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY---NVRVASRYFKGPELLVDY 207 I+HRD+K NV++D + + R+ D+G+A + + + + PE Y Sbjct: 139 PHIIHRDMKSSNVLLD-ENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY---Y 194 Query: 208 QMYDYSL--DMWSLGCMLASMIFRREP 232 Q + S D++S G +L ++ + P Sbjct: 195 QSFRCSTKGDVYSYGVVLLELLTGKRP 221 >5VDK-A nrPDB Length = 297 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 10/28 (35%), Positives = 18/28 (64%) Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKK 171 L+Y H+ ++H D+KP N+ I H+ + Sbjct: 131 GLNYIHNSSMVHLDIKPSNIFICHKMQS 158 >3LMG-A nrPDB Length = 344 Score = 30.0 bits (66), Expect = 1.5, Method: Compositional matrix adjust. Identities = 23/97 (23%), Positives = 47/97 (48%), Gaps = 4/97 (4%) Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP-AQEYNVRVASRYF 198 ++ K + Y G++HR++ NV++ ++++ D+G+A+ P ++ A Sbjct: 141 QIAKGMYYLEEHGMVHRNLAARNVLLK-SPSQVQVADFGVADLLPPDDKQLLYSEAKTPI 199 Query: 199 KGPEL-LVDYQMYDYSLDMWSLGCMLAS-MIFRREPF 233 K L + + Y + D+WS G + M F EP+ Sbjct: 200 KWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPY 236 >5OAT-A nrPDB Length = 411 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 22/98 (22%), Positives = 44/98 (44%), Gaps = 15/98 (15%) Query: 152 GIMHRDVKPHNVMIDHQQKK---LRLIDWGLA------EFYHPAQEYNV-RVASRYFKGP 201 GI HRD+K N+++D + + L + D+G P Y + + + P Sbjct: 173 GIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAP 232 Query: 202 ELLVD----YQMYDYS-LDMWSLGCMLASMIFRREPFF 234 E++ + + +YS D+W++G + + PF+ Sbjct: 233 EIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFY 270 >6BFN-A nrPDB Length = 342 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 26/42 (61%), Gaps = 3/42 (7%) Query: 143 KALDYCH--SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF 182 +A+ + H S ++H D+K NV++D + +L D+GLA F Sbjct: 136 RAIQFLHQDSPSLIHGDIKSSNVLLDERLTP-KLGDFGLARF 176 >5E8V-A nrPDB Length = 316 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 44/212 (20%), Positives = 89/212 (41%), Gaps = 29/212 (13%) Query: 46 LGRGKYSEVFEAINITNN----ERVVVKILKPVKKKKIKREVKILENLR-GGTNIIKLI- 99 +G+G+++EV++A N E V VKI + K E I ++ NI++ + Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLT 76 Query: 100 -DTVKDPVSKTPALVFEYINNTDFKQ--LYQILTDFDIRFYMYELLKALDYCHSK----- 151 + K + K L+ + + ++ +++ D+R L + + + HS Sbjct: 77 AEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCG 136 Query: 152 ----GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN-----VRVASRYFKGPE 202 I+HRD+K N+++ + L D+GL+ P + +V + + PE Sbjct: 137 RPKMPIVHRDLKSSNILVKNDLTCC-LCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPE 195 Query: 203 LLVDYQMYD-----YSLDMWSLGCMLASMIFR 229 +L + D++S+ +L M R Sbjct: 196 VLASAMNLENVESFKQTDVYSMALVLWEMTSR 227 >5TOS-A nrPDB Length = 395 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 26/99 (26%), Positives = 47/99 (47%), Gaps = 9/99 (9%) Query: 143 KALDYCHSK--GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY---NVRVASRY 197 K L + HS +++RD+K N+++D +L D+GLA P + + RV Y Sbjct: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLAR-DGPMGDLSYVSTRVMGTY 243 Query: 198 -FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFH 235 + PE + + S D++S G +L ++ + H Sbjct: 244 GYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDH 281 >4L00-A nrPDB Length = 304 Score = 29.3 bits (64), Expect = 2.8, Method: Compositional matrix adjust. Identities = 25/98 (25%), Positives = 42/98 (42%), Gaps = 9/98 (9%) Query: 140 ELLKALDYCHSKGIMHRDVKPHNVM-----IDHQQKK-LRLIDWGLAEFYHPAQEYNVRV 193 +L AL Y K ++H +V N++ ID + ++L D G+ QE R+ Sbjct: 141 QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERI 200 Query: 194 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRRE 231 + PE + D + + D WS G L + + E Sbjct: 201 P---WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGE 235 >5UU1-A nrPDB Length = 324 Score = 28.9 bits (63), Expect = 3.8, Method: Compositional matrix adjust. Identities = 14/46 (30%), Positives = 27/46 (58%), Gaps = 1/46 (2%) Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQK-KLRLIDWGLAEFYHP 185 +L L+Y H +H D+K N+++ ++ ++ L D+GL+ Y P Sbjct: 139 MLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCP 184 >4NK7-A nrPDB Length = 223 Score = 28.5 bits (62), Expect = 4.5, Method: Compositional matrix adjust. Identities = 14/31 (45%), Positives = 19/31 (61%), Gaps = 2/31 (6%) Query: 107 SKTPALVFEYINNTDFKQLYQILTDFDIRFY 137 SKTP + Y + QL + +TDF+IRFY Sbjct: 119 SKTPKVT--YFSTLGKCQLMETMTDFEIRFY 147 >1JKF-A nrPDB Length = 533 Score = 28.1 bits (61), Expect = 5.8, Method: Compositional matrix adjust. Identities = 21/87 (24%), Positives = 39/87 (44%), Gaps = 5/87 (5%) Query: 66 VVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALV-----FEYINNT 120 +V+K +KPV K+ + E + GG N I + + +D + TP ++ E+ Sbjct: 400 IVIKYMKPVGDSKVAMDEYYSELMLGGHNRISIHNVCEDSLLATPLIIDLLVMTEFCTRV 459 Query: 121 DFKQLYQILTDFDIRFYMYELLKALDY 147 +K++ + D Y +L L Y Sbjct: 460 SYKKVDPVKEDAGKFENFYPVLTFLSY 486 >3IC9-A nrPDB Length = 492 Score = 28.1 bits (61), Expect = 6.1, Method: Compositional matrix adjust. Identities = 9/27 (33%), Positives = 19/27 (70%) Query: 305 LLRYDHQQRLTAKEAMEHPYFYPVVKE 331 LL + QQ++T + + P+++PV++E Sbjct: 431 LLAWARQQQMTVQAMLTMPFYHPVIEE 457 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6HMD-A nrPDB 495 e-140 4MD7-E nrPDB 413 e-116 6EII-A nrPDB 395 e-110 2PVN-A nrPDB 375 e-104 6O6Q-A nrPDB 370 e-103 5XVU-A nrPDB 352 1e-97 4EWQ-A nrPDB 311 2e-85 4LFI-A nrPDB 311 4e-85 3OHT-A nrPDB 309 2e-84 2BPM-A nrPDB 300 7e-82 5Z33-A nrPDB 299 1e-81 1CM8-A nrPDB 297 5e-81 5JN2-A nrPDB 296 7e-81 3NCG-A nrPDB 296 1e-80 3NIZ-A nrPDB 295 2e-80 3OZ6-A nrPDB 295 2e-80 4MYG-A nrPDB 293 1e-79 3GC9-A nrPDB 292 2e-79 2F9G-A nrPDB 291 3e-79 4IC8-A nrPDB 290 5e-79 4MVF-A nrPDB 288 2e-78 3HZT-A nrPDB 288 3e-78 6GU6-A nrPDB 286 7e-78 3MA6-A nrPDB 286 1e-77 5NGU-A nrPDB 284 3e-77 3DFA-A nrPDB 284 3e-77 4QTB-A nrPDB 284 4e-77 6DTL-A nrPDB 284 4e-77 1JNK-A nrPDB 284 4e-77 3DXN-A nrPDB 284 5e-77 1V0B-A nrPDB 283 7e-77 4KRC-A nrPDB 283 9e-77 3LIJ-A nrPDB 282 2e-76 4ZSG-A nrPDB 281 4e-76 3E7O-A nrPDB 281 5e-76 4AU8-A nrPDB 278 3e-75 4AGU-A nrPDB 277 4e-75 2XS0-A nrPDB 277 5e-75 3FI2-A nrPDB 276 8e-75 5FG8-A nrPDB 276 9e-75 5AWM-A nrPDB 275 2e-74 2BDW-A nrPDB 275 2e-74 2VN9-A nrPDB 275 2e-74 5EFQ-A nrPDB 274 3e-74 3Q5I-A nrPDB 274 5e-74 4YZB-A nrPDB 273 9e-74 4QNY-A nrPDB 272 1e-73 3KK8-A nrPDB 272 2e-73 5AIR-A nrPDB 271 3e-73 3MIA-A nrPDB 271 3e-73 4NST-A nrPDB 271 4e-73 1UA2-A nrPDB 269 1e-72 2V7O-A nrPDB 269 1e-72 4NIF-A nrPDB 269 1e-72 5U6Y-A nrPDB 269 2e-72 1G3N-A nrPDB 268 2e-72 2YCR-A nrPDB 268 3e-72 4E7W-A nrPDB 267 4e-72 4BBM-A nrPDB 267 5e-72 2VZ6-A nrPDB 267 5e-72 3BHH-A nrPDB 266 1e-71 4RGJ-A nrPDB 266 2e-71 3SOA-A nrPDB 265 2e-71 5WAX-A nrPDB 264 4e-71 5IG1-A nrPDB 264 4e-71 5Y86-A nrPDB 264 4e-71 2JC6-A nrPDB 264 5e-71 2YAB-A nrPDB 261 3e-70 2A27-A nrPDB 261 3e-70 2W4O-A nrPDB 260 5e-70 4JG6-A nrPDB 260 6e-70 3GC0-A nrPDB 260 6e-70 3PG1-A nrPDB 260 6e-70 4FG9-A nrPDB 260 6e-70 3F3Z-A nrPDB 259 1e-69 1ZWS-A nrPDB 259 1e-69 4O2Z-A nrPDB 259 2e-69 4BGQ-A nrPDB 258 2e-69 5G6V-A nrPDB 258 3e-69 2J90-A nrPDB 257 4e-69 3ZUT-A nrPDB 257 7e-69 2Y7J-A nrPDB 257 7e-69 3ZDU-A nrPDB 257 7e-69 3UC3-A nrPDB 256 9e-69 1PHK-A nrPDB 256 1e-68 3E3P-A nrPDB 256 1e-68 2JAM-A nrPDB 256 1e-68 5YKS-A nrPDB 256 2e-68 3MN3-A nrPDB 255 2e-68 1NY3-A nrPDB 255 2e-68 3UTO-A nrPDB 255 2e-68 3TAC-A nrPDB 255 2e-68 3RP9-A nrPDB 254 4e-68 2OZA-A nrPDB 254 5e-68 3UDB-A nrPDB 254 5e-68 3I6U-A nrPDB 254 5e-68 5XZW-A nrPDB 254 5e-68 2HW6-A nrPDB 254 6e-68 3KA0-A nrPDB 254 6e-68 5ES1-A nrPDB 254 6e-68 1KOA-A nrPDB 253 1e-67 2QNJ-A nrPDB 252 1e-67 3N9X-A nrPDB 251 4e-67 5ZTN-A nrPDB 250 5e-67 3GUB-A nrPDB 250 6e-67 3NIE-A nrPDB 249 1e-66 3KN6-A nrPDB 249 1e-66 5KZ7-A nrPDB 249 2e-66 1FOT-A nrPDB 249 2e-66 2I6L-A nrPDB 248 3e-66 3H4J-B nrPDB 248 3e-66 4REW-A nrPDB 247 4e-66 5JZN-A nrPDB 247 6e-66 3EB0-A nrPDB 247 7e-66 4CFF-A nrPDB 247 7e-66 6FDY-U nrPDB 246 8e-66 1KOB-A nrPDB 246 9e-66 5EZV-A nrPDB 246 1e-65 6CKI-A nrPDB 246 1e-65 2X4F-A nrPDB 246 1e-65 4PDS-A nrPDB 246 1e-65 3FXW-A nrPDB 246 1e-65 2W96-B nrPDB 246 1e-65 6FD3-A nrPDB 244 3e-65 3IS5-A nrPDB 244 3e-65 4UZD-A nrPDB 244 4e-65 3COM-A nrPDB 243 7e-65 2HAK-A nrPDB 243 7e-65 4CFH-A nrPDB 243 9e-65 4D28-A nrPDB 242 1e-64 6C9D-A nrPDB 242 1e-64 2JDO-A nrPDB 242 2e-64 6CMJ-A nrPDB 242 2e-64 4RED-A nrPDB 242 2e-64 3D2K-A nrPDB 242 2e-64 4D2V-A nrPDB 242 2e-64 5KCV-A nrPDB 242 2e-64 2YZA-A nrPDB 241 4e-64 3MV5-A nrPDB 240 6e-64 4FIE-A nrPDB 240 7e-64 4CQG-A nrPDB 240 9e-64 4KS7-A nrPDB 239 1e-63 4JDH-A nrPDB 239 2e-63 5F9E-A nrPDB 239 2e-63 4CZT-A nrPDB 238 2e-63 4JXF-A nrPDB 238 2e-63 2F57-A nrPDB 238 3e-63 4L42-A nrPDB 237 4e-63 3DB8-A nrPDB 237 4e-63 4LG4-A nrPDB 236 1e-62 2UV2-A nrPDB 236 1e-62 4RLP-A nrPDB 236 1e-62 2Q0N-A nrPDB 236 1e-62 4XBR-A nrPDB 236 1e-62 3HDN-A nrPDB 235 2e-62 6AO5-A nrPDB 234 4e-62 5LOH-A nrPDB 234 4e-62 5D7A-A nrPDB 234 5e-62 3TXO-A nrPDB 234 5e-62 1VZO-A nrPDB 234 6e-62 3DAK-A nrPDB 234 7e-62 5YV8-A nrPDB 233 8e-62 4B6L-A nrPDB 233 9e-62 3Q53-A nrPDB 232 1e-61 5D9K-A nrPDB 232 1e-61 5N23-A nrPDB 232 1e-61 5X3F-B nrPDB 232 1e-61 4I6B-A nrPDB 232 2e-61 4RA4-A nrPDB 232 2e-61 5X8I-B nrPDB 231 4e-61 5J5T-A nrPDB 231 4e-61 4WB7-A nrPDB 230 5e-61 3ORZ-A nrPDB 230 5e-61 3LM0-A nrPDB 229 2e-60 2OU7-A nrPDB 228 2e-60 4J52-A nrPDB 228 3e-60 3HKO-A nrPDB 226 8e-60 4YNZ-A nrPDB 226 8e-60 6FYV-A nrPDB 226 9e-60 2Z7Q-A nrPDB 226 1e-59 6HXF-B nrPDB 225 2e-59 5DYK-A nrPDB 225 2e-59 3A8W-A nrPDB 225 3e-59 3RAW-A nrPDB 223 7e-59 5DBX-A nrPDB 223 9e-59 6E2O-A nrPDB 223 1e-58 6E9W-A nrPDB 222 1e-58 3PFQ-A nrPDB 221 3e-58 2XIK-A nrPDB 221 3e-58 3TKU-A nrPDB 221 3e-58 3M42-A nrPDB 221 3e-58 4C0T-A nrPDB 221 4e-58 6ED6-A nrPDB 220 7e-58 3NYO-A nrPDB 220 8e-58 5FET-A nrPDB 220 9e-58 5UNP-A nrPDB 220 9e-58 2I0E-A nrPDB 219 1e-57 4WNO-A nrPDB 218 2e-57 4QMW-A nrPDB 218 3e-57 4U41-A nrPDB 217 5e-57 4AW2-A nrPDB 217 7e-57 6BDL-A nrPDB 217 7e-57 6QAU-A nrPDB 217 8e-57 4FZF-B nrPDB 217 8e-57 2JD5-A nrPDB 216 9e-57 4CRL-A nrPDB 216 1e-56 4B8L-A nrPDB 216 1e-56 4TNB-A nrPDB 216 1e-56 4AF3-A nrPDB 215 2e-56 1TKI-A nrPDB 215 2e-56 6CCF-A nrPDB 214 5e-56 6CQF-A nrPDB 214 6e-56 2BRG-A nrPDB 213 9e-56 5TQX-A nrPDB 212 1e-55 4FR4-A nrPDB 212 2e-55 2WO6-A nrPDB 212 2e-55 2X7G-A nrPDB 212 2e-55 1U5R-A nrPDB 211 4e-55 5UUU-A nrPDB 210 5e-55 2GCD-A nrPDB 210 9e-55 3PVW-A nrPDB 210 1e-54 4WUA-A nrPDB 209 1e-54 5KKR-C nrPDB 209 2e-54 4KIK-B nrPDB 209 2e-54 3ALO-A nrPDB 208 3e-54 2VD5-A nrPDB 208 3e-54 4APC-A nrPDB 208 3e-54 3EQC-A nrPDB 207 4e-54 4F9B-A nrPDB 207 6e-54 4PWN-A nrPDB 205 2e-53 3QA8-A nrPDB 205 3e-53 4OTD-A nrPDB 205 3e-53 2XNP-A nrPDB 205 3e-53 2WQN-A nrPDB 204 4e-53 5O2B-A nrPDB 204 5e-53 3C51-A nrPDB 203 1e-52 5O2C-A nrPDB 203 1e-52 2WTK-C nrPDB 202 1e-52 3VN9-A nrPDB 202 2e-52 6BXI-A nrPDB 202 2e-52 4CRS-A nrPDB 201 3e-52 4CSV-A nrPDB 200 5e-52 4OLI-A nrPDB 200 5e-52 3FME-A nrPDB 200 9e-52 6GQK-A nrPDB 200 1e-51 4YHJ-A nrPDB 198 3e-51 5O0Y-A nrPDB 198 3e-51 6DBM-A nrPDB 197 8e-51 1ZXE-A nrPDB 197 8e-51 1S9I-A nrPDB 196 1e-50 2OGV-A nrPDB 196 1e-50 3BEA-A nrPDB 196 2e-50 4IAN-A nrPDB 195 2e-50 3TT0-A nrPDB 195 2e-50 4AN9-A nrPDB 195 3e-50 3KRL-A nrPDB 194 4e-50 4E20-A nrPDB 194 4e-50 3G0E-A nrPDB 194 5e-50 6GVJ-A nrPDB 194 5e-50 4GS6-A nrPDB 194 6e-50 5X02-A nrPDB 193 9e-50 5A46-A nrPDB 193 9e-50 3GQL-A nrPDB 193 1e-49 3PPZ-A nrPDB 192 2e-49 5TUR-A nrPDB 192 2e-49 3OMV-A nrPDB 192 2e-49 4XUF-A nrPDB 192 2e-49 3BGP-A nrPDB 192 3e-49 5HI2-A nrPDB 192 3e-49 4R7H-A nrPDB 191 4e-49 4RC3-A nrPDB 190 5e-49 3HMP-A nrPDB 190 7e-49 5H2U-A nrPDB 190 9e-49 3DLS-A nrPDB 190 9e-49 4UY9-A nrPDB 190 1e-48 3CJF-A nrPDB 189 1e-48 2PSQ-A nrPDB 189 1e-48 5AP3-A nrPDB 189 2e-48 4XEY-B nrPDB 189 2e-48 3DTC-A nrPDB 188 3e-48 2W1I-A nrPDB 188 3e-48 2PL0-A nrPDB 188 3e-48 4EBW-A nrPDB 188 3e-48 2ZMD-A nrPDB 188 4e-48 4EQM-A nrPDB 188 4e-48 6DBN-A nrPDB 187 6e-48 5HIE-A nrPDB 187 6e-48 2DQ7-X nrPDB 187 6e-48 2FO0-A nrPDB 187 7e-48 4XCU-A nrPDB 187 8e-48 2J0K-A nrPDB 185 2e-47 4K33-A nrPDB 185 2e-47 3ORP-A nrPDB 185 2e-47 3A4O-X nrPDB 185 3e-47 5EG3-A nrPDB 185 3e-47 4UYA-A nrPDB 185 3e-47 4XLV-A nrPDB 185 3e-47 3V5Q-A nrPDB 184 4e-47 5GRN-A nrPDB 184 5e-47 4PL5-B nrPDB 184 5e-47 6HV0-A nrPDB 184 5e-47 6NPU-A nrPDB 184 8e-47 4HVI-A nrPDB 184 8e-47 4X7Q-B nrPDB 183 9e-47 2XYN-A nrPDB 183 9e-47 3IO7-A nrPDB 183 1e-46 4C59-A nrPDB 182 1e-46 4AT3-A nrPDB 182 2e-46 4H1J-A nrPDB 182 2e-46 4E93-A nrPDB 181 4e-46 3LLT-A nrPDB 181 5e-46 2HK5-A nrPDB 180 6e-46 5X5O-A nrPDB 178 2e-45 2RIO-A nrPDB 178 3e-45 4JLC-A nrPDB 178 4e-45 1AD5-A nrPDB 176 1e-44 5B2L-A nrPDB 176 1e-44 5AMN-A nrPDB 176 1e-44 4EUU-A nrPDB 176 1e-44 4M7I-A nrPDB 176 2e-44 2PMN-X nrPDB 175 3e-44 4EUT-A nrPDB 175 3e-44 4P5Q-A nrPDB 175 3e-44 2A1A-B nrPDB 174 4e-44 5HLW-A nrPDB 174 4e-44 6NT9-A nrPDB 172 2e-43 2WTK-B nrPDB 172 2e-43 6O8B-A nrPDB 172 2e-43 5VD3-A nrPDB 172 2e-43 4IDT-A nrPDB 172 2e-43 1K9A-A nrPDB 172 2e-43 3BBT-B nrPDB 172 3e-43 6E4F-A nrPDB 171 4e-43 1BYG-A nrPDB 171 4e-43 3UIU-A nrPDB 171 4e-43 4XI2-A nrPDB 170 6e-43 6B2Q-A nrPDB 170 7e-43 4X3F-A nrPDB 170 7e-43 4OW8-A nrPDB 170 7e-43 4Y93-A nrPDB 170 9e-43 3C1X-A nrPDB 170 9e-43 6CTH-A nrPDB 169 1e-42 4Y83-A nrPDB 169 1e-42 4YFF-A nrPDB 168 2e-42 4G3E-A nrPDB 168 4e-42 5HVK-A nrPDB 166 1e-41 4LQP-A nrPDB 166 2e-41 2BUJ-A nrPDB 165 4e-41 5TE0-A nrPDB 164 4e-41 5GNK-A nrPDB 164 4e-41 3LZB-A nrPDB 164 5e-41 4TPT-A nrPDB 164 5e-41 3QUP-A nrPDB 164 6e-41 3PLS-A nrPDB 164 6e-41 3MY0-A nrPDB 163 9e-41 4LRM-A nrPDB 163 1e-40 5IKW-A nrPDB 161 5e-40 4M66-A nrPDB 158 2e-39 3MDY-A nrPDB 157 5e-39 5L2Q-C nrPDB 155 2e-38 4NEU-A nrPDB 154 6e-38 5WNL-A nrPDB 153 7e-38 6DC0-A nrPDB 150 6e-37 3QD2-B nrPDB 149 2e-36 5CEK-A nrPDB 148 4e-36 3SOC-A nrPDB 148 4e-36 2H34-A nrPDB 146 2e-35 2QLU-A nrPDB 140 1e-33 3SV0-A nrPDB 137 9e-33 2Y4I-B nrPDB 135 2e-32 2CHL-A nrPDB 135 3e-32 4TN6-A nrPDB 133 1e-31 5FQD-C nrPDB 131 4e-31 2C47-A nrPDB 131 5e-31 4BTK-A nrPDB 130 9e-31 4NFN-A nrPDB 129 2e-30 2CMW-A nrPDB 129 2e-30 2PZI-A nrPDB 129 2e-30 4Y12-A nrPDB 128 2e-30 3HNG-A nrPDB 125 2e-29 5X18-A nrPDB 125 3e-29 4NT4-A nrPDB 125 3e-29 3VHK-A nrPDB 125 3e-29 4RT7-A nrPDB 123 9e-29 5M07-A nrPDB 121 6e-28 4JRN-A nrPDB 115 3e-26 4XHH-A nrPDB 114 5e-26 1CSN-A nrPDB 113 9e-26 4XHL-A nrPDB 111 5e-25 4IX6-A nrPDB 98 4e-21 4CI6-B nrPDB 85 3e-17 4AZW-A nrPDB 66 2e-11 Sequences not found previously or not previously below threshold: 2H8H-A nrPDB 189 2e-48 6F3F-A nrPDB 189 2e-48 5SYS-A nrPDB 186 1e-47 6FEX-A nrPDB 178 3e-45 1FVR-A nrPDB 177 5e-45 3QGY-A nrPDB 176 1e-44 6BSD-A nrPDB 176 2e-44 2VWV-A nrPDB 176 2e-44 5VO2-A nrPDB 175 3e-44 2R2P-A nrPDB 175 3e-44 3DKO-A nrPDB 175 3e-44 2Y6O-A nrPDB 175 4e-44 5KMM-A nrPDB 173 7e-44 5MJB-A nrPDB 173 9e-44 5L6P-A nrPDB 172 2e-43 3KUL-B nrPDB 172 3e-43 1JPA-A nrPDB 172 3e-43 5FM2-A nrPDB 171 5e-43 3SXS-A nrPDB 170 7e-43 4PDO-A nrPDB 169 2e-42 3PP0-A nrPDB 168 4e-42 1LUF-A nrPDB 168 4e-42 1U59-A nrPDB 167 8e-42 6FER-A nrPDB 167 8e-42 3Q4U-A nrPDB 165 3e-41 2OZO-A nrPDB 164 4e-41 3ZBF-A nrPDB 164 5e-41 3I81-A nrPDB 163 7e-41 4HZS-A nrPDB 163 1e-40 1U54-B nrPDB 162 3e-40 5UIU-A nrPDB 159 1e-39 5U6B-A nrPDB 158 2e-39 1PY5-A nrPDB 156 2e-38 5TOS-A nrPDB 154 5e-38 5U6C-A nrPDB 150 8e-37 3G2F-A nrPDB 150 1e-36 4F0G-A nrPDB 149 1e-36 3AOX-A nrPDB 149 1e-36 5LPZ-A nrPDB 148 3e-36 5LPV-A nrPDB 147 5e-36 3UIM-A nrPDB 147 5e-36 6J5U-C nrPDB 147 8e-36 5E8V-A nrPDB 145 2e-35 3ZZW-A nrPDB 145 2e-35 5WNO-A nrPDB 145 3e-35 4FL3-A nrPDB 143 1e-34 5C26-A nrPDB 141 4e-34 5XD6-A nrPDB 140 9e-34 2QKW-B nrPDB 137 8e-33 5AR8-A nrPDB 137 1e-32 3LMG-A nrPDB 136 1e-32 5VC6-A nrPDB 133 7e-32 5J0A-A nrPDB 133 2e-31 5VDK-A nrPDB 129 2e-30 6BFN-A nrPDB 121 6e-28 4MWI-A nrPDB 110 1e-24 5UV4-A nrPDB 106 1e-23 5X1R-A nrPDB 104 6e-23 4M69-B nrPDB 102 2e-22 4BTF-A nrPDB 102 2e-22 4L00-A nrPDB 100 1e-21 5OAT-A nrPDB 97 8e-21 5USZ-A nrPDB 96 2e-20 6EQI-C nrPDB 93 2e-19 3REP-A nrPDB 93 2e-19 5CLR-A nrPDB 90 1e-18 6J6I-B nrPDB 87 9e-18 5C01-A nrPDB 83 1e-16 4WOV-A nrPDB 83 1e-16 5DMZ-A nrPDB 83 1e-16 4L68-A nrPDB 83 1e-16 6G4J-A nrPDB 82 3e-16 5UU1-A nrPDB 78 5e-15 4I94-A nrPDB 78 6e-15 2RSV-A nrPDB 75 6e-14 2LAV-A nrPDB 73 2e-13 4O1O-A nrPDB 69 3e-12 4AZV-A nrPDB 65 3e-11 2JII-A nrPDB 63 3e-10 4OAU-C nrPDB 62 5e-10 6EWX-A nrPDB 59 3e-09 5GZA-A nrPDB 55 5e-08 4CYJ-A nrPDB 55 6e-08 5GZ9-A nrPDB 52 3e-07 6EAS-A nrPDB 51 5e-07 6M7Z-A nrPDB 51 5e-07 6BHC-A nrPDB 50 1e-06 5VE6-A nrPDB 49 3e-06 3ENH-A nrPDB 48 6e-06 3Q60-A nrPDB 48 9e-06 4WWA-A nrPDB 46 2e-05 6G38-A nrPDB 46 2e-05 3BYV-A nrPDB 46 3e-05 1TQM-A nrPDB 46 3e-05 2W1Z-A nrPDB 45 6e-05 3DZO-A nrPDB 44 9e-05 4CZY-B nrPDB 42 4e-04 5YK0-A nrPDB 42 5e-04 6G18-v nrPDB 39 0.003 4BVU-A nrPDB 38 0.005 6FDN-A nrPDB 38 0.005 6FAI-l nrPDB 38 0.006 5I35-A nrPDB 38 0.006 4BWP-A nrPDB 36 0.034 6EF6-A nrPDB 32 0.35 4W91-A nrPDB 31 0.52 5M3Y-A nrPDB 31 0.58 1WP5-A nrPDB 31 0.79 >6HMD-A nrPDB Length = 365 Score = 495 bits (1274), Expect = e-140, Method: Composition-based stats. Identities = 349/350 (99%), Positives = 349/350 (99%) Query: 1 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 60 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI Sbjct: 16 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 75 Query: 61 TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 120 TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT Sbjct: 76 TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 135 Query: 121 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA Sbjct: 136 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 195 Query: 181 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY Sbjct: 196 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 255 Query: 241 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD Sbjct: 256 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 315 Query: 301 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR 350 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQP ADNAVLSSGLTAAR Sbjct: 316 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPSADNAVLSSGLTAAR 365 >4MD7-E nrPDB Length = 391 Score = 413 bits (1062), Expect = e-116, Method: Composition-based stats. Identities = 289/355 (81%), Positives = 314/355 (88%), Gaps = 7/355 (1%) Query: 1 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 60 M GP SRARVY +VN+ R REYWDYE+HV WGNQDDYQLVRKLGRGKYSEVFEAINI Sbjct: 1 MSGPVP-SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINI 59 Query: 61 TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 120 TNNE+VVVKILKPVKKKKIKRE+KILENLRGG NII L D VKDPVS+TPALVFE++NNT Sbjct: 60 TNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119 Query: 121 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180 DFKQLYQ LTD+DIRFYMYE+LKALDYCHS GIMHRDVKPHNVMIDH+ +KLRLIDWGLA Sbjct: 120 DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 Query: 181 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240 EFYHP QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR+EPFFHG DNY Sbjct: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239 Query: 241 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300 DQLVRIAKVLGTE+LY Y+ KY+I+LDP FNDILG+HSRKRWE F+HSEN+HLVSPEALD Sbjct: 240 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299 Query: 301 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ------SQPCADNAVLSSGLTAA 349 LDKLLRYDHQ RLTA+EAMEHPYFY VVK+Q S P V S+ + + Sbjct: 300 FLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSEPVSSANMMSG 354 >6EII-A nrPDB Length = 352 Score = 395 bits (1016), Expect = e-110, Method: Composition-based stats. Identities = 280/323 (86%), Positives = 301/323 (93%) Query: 8 SRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVV 67 SRARVY +VN+ R EYWDYE+HV WGNQDDYQLVRKLGRGKYSEVFEAINITNNE+VV Sbjct: 30 SRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVV 89 Query: 68 VKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ 127 VKILKPVKKKKIKRE+KILENLRGG NII L D VKDPVS+TPALVFE++NNTDFKQLYQ Sbjct: 90 VKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQ 149 Query: 128 ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ 187 LTD+DIRFYMYE+LKALDYCHS GIMHRDVKPHNVMIDH+ +KLRLIDWGLAEFYHP Q Sbjct: 150 TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ 209 Query: 188 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIA 247 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR+EPFFHG DNYDQLVRIA Sbjct: 210 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIA 269 Query: 248 KVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLR 307 KVLGTE+LY Y+ KY+I+LDP FNDILG+HSRKRWE F+HSEN+HLVSPEALD LDKLLR Sbjct: 270 KVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLR 329 Query: 308 YDHQQRLTAKEAMEHPYFYPVVK 330 YDHQ RLTA+EAMEHPYFY VVK Sbjct: 330 YDHQSRLTAREAMEHPYFYTVVK 352 >2PVN-A nrPDB Length = 352 Score = 375 bits (964), Expect = e-104, Method: Composition-based stats. Identities = 239/337 (70%), Positives = 284/337 (84%) Query: 1 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 60 +P + S+ARVYA+VN LR +EYWDYEA WG QDDY++VRK+GRGKYSEVFE IN+ Sbjct: 15 VPRGSHMSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINV 74 Query: 61 TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 120 NNE+ ++KILKPVKKKKIKRE+KIL+NL GG NI+KL+D V+D SKTP+L+FEY+NNT Sbjct: 75 NNNEKCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNT 134 Query: 121 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180 DFK LY LTD+DIR+Y+YELLKALDYCHS+GIMHRDVKPHNVMIDH+ +KLRLIDWGLA Sbjct: 135 DFKVLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLA 194 Query: 181 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240 EFYHP +EYNVRVASRYFKGPELLVD Q YDYSLDMWSLGCM A MIFR+EPFF+G DN+ Sbjct: 195 EFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNH 254 Query: 241 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300 DQLV+IAKVLGT+ L YL KY I+LDP ++G+HSRK W F++++N+HLVSPEA+D Sbjct: 255 DQLVKIAKVLGTDGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAID 314 Query: 301 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCA 337 LDKLLRYDHQ+RLTA EAM HPYF V ++ Sbjct: 315 FLDKLLRYDHQERLTALEAMTHPYFQQVRAAENSRTR 351 >6O6Q-A nrPDB Length = 335 Score = 370 bits (950), Expect = e-103, Method: Composition-based stats. Identities = 207/325 (63%), Positives = 260/325 (80%), Gaps = 1/325 (0%) Query: 5 AAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE 64 S +RVYA+V S + + YWDY+ W Q++Y+++RKLGRGKYSEVF I++ E Sbjct: 8 TVQSVSRVYADVLSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKRE 67 Query: 65 RVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQ 124 +VV+K+LKPVK+KKIKRE+ IL+NL G NII ++D V++P SKTP L+FE+INN DF+ Sbjct: 68 KVVIKVLKPVKRKKIKREISILKNLVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRS 127 Query: 125 LYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH 184 LY TD+DIRFYMYELLKALDY HS GIMHRDVKPHNVMIDH +K LRLIDWGLAE+YH Sbjct: 128 LYPTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYH 187 Query: 185 PAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLV 244 P EYNVRVASRYFKGPELLVDY++YDYSLDMWS GCMLASM+F +EPFFHG+ N DQLV Sbjct: 188 PGTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLV 247 Query: 245 RIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDK 304 +I +VLG++ YL+KY+I L + DI G +++++W F++ N+ LVS E LDL+D+ Sbjct: 248 QIVRVLGSKNFKKYLEKYNISLGEEYEDI-GYYNKRQWVRFMNENNKDLVSQEFLDLIDR 306 Query: 305 LLRYDHQQRLTAKEAMEHPYFYPVV 329 LLRYDHQ+RLTAKEAM+H YF P+ Sbjct: 307 LLRYDHQERLTAKEAMKHAYFDPIR 331 >5XVU-A nrPDB Length = 332 Score = 352 bits (903), Expect = 1e-97, Method: Composition-based stats. Identities = 205/323 (63%), Positives = 260/323 (80%) Query: 11 RVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI 70 + YA+VN + +EY+DY+ W + Y++++K+GRGKYSEVF + N +K+ Sbjct: 4 KFYADVNIHKPKEYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKV 63 Query: 71 LKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILT 130 LKPVKKKKIKRE+KIL+NL GG NIIKL+D VKDPV+KTP+L+FEYINN DFK LY T Sbjct: 64 LKPVKKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTLYPKFT 123 Query: 131 DFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN 190 D DIR+Y+Y++LKALDYCHS+GIMHRDVKPHN+MIDH+ +++RLI WGLAEFYHP QEYN Sbjct: 124 DKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYN 183 Query: 191 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVL 250 VRVASRY+KGPELL+D Q+YDYSLD+WSLGCMLA MIF++EPFF G DNYDQLV+IAKVL Sbjct: 184 VRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVL 243 Query: 251 GTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDH 310 GTE+L+ YLKKY+I L PH+ +ILG++ RK W +F+ N + E +DL+DK+L YDH Sbjct: 244 GTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDH 303 Query: 311 QQRLTAKEAMEHPYFYPVVKEQS 333 +R+ KEAMEHPYF V +E + Sbjct: 304 AKRIAPKEAMEHPYFREVREESA 326 >4EWQ-A nrPDB Length = 383 Score = 311 bits (798), Expect = 2e-85, Method: Composition-based stats. Identities = 101/340 (29%), Positives = 177/340 (52%), Gaps = 24/340 (7%) Query: 12 VYAEVNSLRSRE-YWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI 70 +Y + N+ + R ++ E + W + YQ + +G G Y V A + RV VK Sbjct: 18 LYFQSNASQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKK 77 Query: 71 LKP-----VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVS----KTPALVFEYINNTD 121 L + K+ RE+++L++++ N+I L+D S LV + D Sbjct: 78 LSRPFQSIIHAKRTYRELRLLKHMKH-ENVIGLLDVFTPARSLEEFNDVYLVTHLM-GAD 135 Query: 122 FKQLY--QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL 179 + Q LTD ++F +Y++L+ L Y HS I+HRD+KP N+ ++ + +L+++D+GL Sbjct: 136 LNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGL 194 Query: 180 AEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDN 239 A H E VA+R+++ PE+++++ Y+ ++D+WS+GC++A ++ R F G D+ Sbjct: 195 AR--HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRT-LFPGTDH 251 Query: 240 YDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEAL 299 DQL I +++GT LKK + ++ L Q + + N N P A+ Sbjct: 252 IDQLKLILRLVGTPGA-ELLKKISSESARNYIQSLTQMPKMNFANVFIGAN-----PLAV 305 Query: 300 DLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADN 339 DLL+K+L D +R+TA +A+ H YF +P AD Sbjct: 306 DLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADP 345 >4LFI-A nrPDB Length = 374 Score = 311 bits (796), Expect = 4e-85, Method: Composition-based stats. Identities = 203/365 (55%), Positives = 250/365 (68%), Gaps = 43/365 (11%) Query: 8 SRARVYAEVNSLRSREYWDYEAHVPSWG-NQDDYQLVRKLGRGKYSEVFEAINITNNERV 66 S ARVY +N R+ EYWDYE V W N DY++ K+GRGKYSEVF+ + + + ++ Sbjct: 9 SEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKI 68 Query: 67 VVKI---------------LKPVKKKKI---------------KREVKILENLR------ 90 V+K+ L + +K+ ++E +L+ +R Sbjct: 69 VIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKE-DVLKFIRPYIFDQ 127 Query: 91 ---GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDY 147 G NII L D +KDP+SKTPALVFEY++N DF+ LY LTD +IRFYM+ELLKALDY Sbjct: 128 PHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDY 187 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 CHS GIMHRDVKPHNVMIDH+ KKLRLIDWGLAEFYH EYNVRVASR+FKGPELLVDY Sbjct: 188 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 247 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 +MYDYSLD+WS G MLASMIF+REPFFHG N DQLV+I KVLGT + YL KY I L Sbjct: 248 RMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLP 307 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLV-SPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 F D+ Q+ RK W FI+ N+HL + E +DL+D LLRYDHQ+RLTAKEAM HP+F Sbjct: 308 REFYDM-DQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 366 Query: 327 PVVKE 331 P+ ++ Sbjct: 367 PIREQ 371 >3OHT-A nrPDB Length = 389 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 96/345 (27%), Positives = 178/345 (51%), Gaps = 24/345 (6%) Query: 6 AGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNER 65 AGS A + + R ++ E + W + YQ + +G G Y V + ++ + + Sbjct: 20 AGSAAAPFTMSHKERPT-FYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLK 78 Query: 66 VVVKILKP-----VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVS----KTPALVFEY 116 + VK L + K+ RE+++L++++ N+I L+D S LV Sbjct: 79 IAVKKLSRPFQSIIHAKRTYRELRLLKHMKH-ENVIGLLDVFTPATSLEEFNDVYLVTHL 137 Query: 117 INNTDFKQLY--QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRL 174 + D + Q LTD ++F +Y++L+ L Y HS I+HRD+KP N+ ++ + +L++ Sbjct: 138 M-GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKI 195 Query: 175 IDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFF 234 +D+GLA H E VA+R+++ PE+++++ Y+ ++D+WS+GC++A ++ R F Sbjct: 196 LDFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRT-LF 252 Query: 235 HGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLV 294 G D+ +QL +I ++ GT + + + N + R + FI + Sbjct: 253 PGTDHINQLQQIMRLTGTPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGAN----- 307 Query: 295 SPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADN 339 P A+DLL+K+L D +R+TA EA+ HPYF +P ++ Sbjct: 308 -PLAVDLLEKMLVLDTDKRITASEALAHPYFSQYHDPDDEPESEP 351 >2BPM-A nrPDB Length = 309 Score = 300 bits (768), Expect = 7e-82, Method: Composition-based stats. Identities = 93/308 (30%), Positives = 160/308 (51%), Gaps = 27/308 (8%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKILENLR 90 + +++Q V K+G G Y V++A N E V +K ++ + + RE+ +L+ L Sbjct: 5 DMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL- 63 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI-----LTDFDIRFYMYELLKAL 145 NI+KL+D + LVFE++ + D K+ + I+ Y+++LL+ L Sbjct: 64 NHPNIVKLLDVIH--TENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 120 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELL 204 +CHS ++HRD+KP N++I+ + ++L D+GLA + P + Y V + +++ PE+L Sbjct: 121 AFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 179 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK-KYH 263 + + Y ++D+WSLGC+ A M+ RR F G DQL RI + LGT + + Sbjct: 180 LGCKYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 238 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 D P F +W S+ + + LL ++L YD +R++AK A+ HP Sbjct: 239 PDYKPSF---------PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 289 Query: 324 YFYPVVKE 331 +F V K Sbjct: 290 FFQDVTKP 297 >5Z33-A nrPDB Length = 425 Score = 299 bits (766), Expect = 1e-81, Method: Composition-based stats. Identities = 93/314 (29%), Positives = 167/314 (53%), Gaps = 22/314 (7%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREVKILENLRGG 92 + Y + ++LG+G Y V A+N +E V +K + K + K+ RE+K+L++ RG Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGH 90 Query: 93 TNIIKLIDT-VKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYC 148 NI L D + P + ++E + D + Q LTD + ++Y++L L Y Sbjct: 91 RNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYI 150 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-----YNVRVASRYFKGPEL 203 HS ++HRD+KP N++++ +L++ D+GLA + E VA+R+++ PE+ Sbjct: 151 HSANVLHRDLKPGNLLVNA-DCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEI 209 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 ++ +Q Y ++D+WS+GC+LA ++ PFF G+D DQL +I +LGT + Sbjct: 210 MLSFQSYTKAIDVWSVGCILAELL-GGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGS 268 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 + + L ++K + + N P+ALDLLD++L +D R++ ++A+EHP Sbjct: 269 PRAQEYVRN-LPFMAKKPFPTLFPNAN-----PDALDLLDRMLAFDPSSRISVEQALEHP 322 Query: 324 YFYPVVKEQSQPCA 337 Y + +P Sbjct: 323 YLHIWHDASDEPDC 336 >1CM8-A nrPDB Length = 367 Score = 297 bits (760), Expect = 5e-81, Method: Composition-based stats. Identities = 94/325 (28%), Positives = 180/325 (55%), Gaps = 23/325 (7%) Query: 22 REYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-KPVKKK--- 77 ++ E +W + Y+ ++ +G G Y V A++ +V +K L +P + + Sbjct: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68 Query: 78 -KIKREVKILENLRGGTNIIKLIDTVKDPVS----KTPALVFEYINNTDFKQL--YQILT 130 + RE+++L+++R N+I L+D + LV ++ TD +L ++ L Sbjct: 69 KRAYRELRLLKHMRH-ENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLG 126 Query: 131 DFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN 190 + I+F +Y++LK L Y H+ GI+HRD+KP N+ ++ + +L+++D+GLA E Sbjct: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLAR--QADSEMT 183 Query: 191 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVL 250 V +R+++ PE+++++ Y ++D+WS+GC++A MI + F G D+ DQL I KV Sbjct: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKT-LFKGSDHLDQLKEIMKVT 242 Query: 251 GTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDH 310 GT ++++ D ++ L + +K + + + + SP A++LL+K+L D Sbjct: 243 GTPPA-EFVQRLQSDEAKNYMKGLPELEKKDFASILTNA-----SPLAVNLLEKMLVLDA 296 Query: 311 QQRLTAKEAMEHPYFYPVVKEQSQP 335 +QR+TA EA+ HPYF + + +P Sbjct: 297 EQRVTAGEALAHPYFESLHDTEDEP 321 >5JN2-A nrPDB Length = 525 Score = 296 bits (759), Expect = 7e-81, Method: Composition-based stats. Identities = 82/320 (25%), Positives = 146/320 (45%), Gaps = 53/320 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP------VKKKKIKREVKILENLRG 91 D Y+ R LG+G + EV + + VK++ K+ + REV++L+ L Sbjct: 67 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL-D 125 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYC 148 NI+KL + +D LV E + + ++ D + ++L + Y Sbjct: 126 HPNIMKLYEFFED--KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYM 183 Query: 149 HSKGIMHRDVKPHNVMID--HQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVD 206 H I+HRD+KP N++++ + +R+ID+GL+ + +++ ++ + Y+ PE+L Sbjct: 184 HKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL-- 241 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 + YD D+WS G +L ++ PF +G + YD L ++ K T EL + K Sbjct: 242 HGTYDEKCDVWSTGVILYILLSGCPPF-NGANEYDILKKVEKGKYTFELPQWKK------ 294 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 VS A DL+ K+L Y R++A++A++H + Sbjct: 295 ---------------------------VSESAKDLIRKMLTYVPSMRISARDALDHEWIQ 327 Query: 327 PVVKEQ---SQPCADNAVLS 343 KEQ P DNA+L+ Sbjct: 328 TYTKEQISVDVPSLDNAILN 347 >3NCG-A nrPDB Length = 486 Score = 296 bits (757), Expect = 1e-80, Method: Composition-based stats. Identities = 79/323 (24%), Positives = 143/323 (44%), Gaps = 50/323 (15%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREVKILENLRGG 92 + Y +V LG+G + EV + + + VK++ K I REV++L+ L Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL-DH 80 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCH 149 NI+KL + ++D S + +V E + + ++ D + ++ + Y H Sbjct: 81 PNIMKLFEILED--SSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH 138 Query: 150 SKGIMHRDVKPHNVMIDHQ--QKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 I+HRD+KP N++++ + +++ID+GL+ + + R+ + Y+ PE+L Sbjct: 139 KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL--R 196 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 YD D+WS G +L ++ PF+ G++ YD L R+ KY DL Sbjct: 197 GTYDEKCDVWSAGVILYILLSGTPPFY-GKNEYDILKRVET-----------GKYAFDLP 244 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 +S +A DL+ K+L + R+TA + +EHP+ Sbjct: 245 ----------------------QWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQK 282 Query: 328 VVKEQSQPCADNAVLSSGLTAAR 350 E + +D L S +T R Sbjct: 283 YSSE-TPTISDLPSLESAMTNIR 304 >3NIZ-A nrPDB Length = 311 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 92/307 (29%), Positives = 160/307 (52%), Gaps = 24/307 (7%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKILENL 89 G + YQ + K+G G Y V++A + + V +K ++ + + RE+ +L+ L Sbjct: 18 GLMEKYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLDAEDEGIPSTAIREISLLKEL 76 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY----QILTDFDIRFYMYELLKAL 145 NI+ LID + + LVFE++ D K++ L D I+ Y+Y+LL+ + Sbjct: 77 -HHPNIVSLIDVIHS--ERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGV 132 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELL 204 +CH I+HRD+KP N++I+ L+L D+GLA + P + Y V + +++ P++L Sbjct: 133 AHCHQHRILHRDLKPQNLLINS-DGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVL 191 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 + + Y S+D+WS+GC+ A MI + P F G + DQL +I +LGT + + Sbjct: 192 MGSKKYSTSVDIWSIGCIFAEMITGK-PLFPGVTDDDQLPKIFSILGTPNPREWPQVQ-- 248 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 +L +K W + I E +DLL +L +D +R++A++AM HPY Sbjct: 249 ELPLWKQRTFQVFEKKPWSSIIPG-----FCQEGIDLLSNMLCFDPNKRISARDAMNHPY 303 Query: 325 FYPVVKE 331 F + + Sbjct: 304 FKDLDPQ 310 >3OZ6-A nrPDB Length = 388 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 95/342 (27%), Positives = 171/342 (50%), Gaps = 42/342 (12%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREVKILENLRGGT 93 Y+LV+KLG+G Y V+++I+ E V VK + ++ RE+ IL L G Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHE 69 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDYCHSK 151 NI+ L++ ++ + LVF+Y+ TD + + IL ++ +Y+L+K + Y HS Sbjct: 70 NIVNLLNVLRADNDRDVYLVFDYME-TDLHAVIRANILEPVHKQYVVYQLIKVIKYLHSG 128 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY----------------------HPAQEY 189 G++HRD+KP N++++ + +++ D+GL+ + Sbjct: 129 GLLHRDMKPSNILLNAE-CHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPIL 187 Query: 190 NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKV 249 VA+R+++ PE+L+ Y +DMWSLGC+L ++ + P F G +QL RI V Sbjct: 188 TDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGK-PIFPGSSTMNQLERIIGV 246 Query: 250 L------GTEELYGYLKKYHIDLDPHFNDILGQHSRK---RWENFIHSEN-RHLVSPEAL 299 + E + K I+ +I + R +W+N + N + + EAL Sbjct: 247 IDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEEAL 306 Query: 300 DLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAV 341 DLLDKLL+++ +R++A +A++HP+ +P D+ + Sbjct: 307 DLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHII 348 >4MYG-A nrPDB Length = 372 Score = 293 bits (749), Expect = 1e-79, Method: Composition-based stats. Identities = 94/337 (27%), Positives = 178/337 (52%), Gaps = 22/337 (6%) Query: 14 AEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK- 72 + ++ +R + ++ + + +W Y +G G Y V AI+ + E+V +K L Sbjct: 19 SHMSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR 78 Query: 73 ----PVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSK----TPALVFEYINNTDFKQ 124 + K+ RE+ +L++++ N+I L+D S LV ++ TD ++ Sbjct: 79 PFQSEIFAKRAYRELLLLKHMQH-ENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-TDLQK 136 Query: 125 LYQI-LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY 183 + + ++ I++ +Y++LK L Y HS G++HRD+KP N+ ++ + +L+++D+GLA Sbjct: 137 IMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLAR-- 193 Query: 184 HPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQL 243 H E V +R+++ PE+++ + Y+ ++D+WS+GC++A M+ + F G+D DQL Sbjct: 194 HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT-LFKGKDYLDQL 252 Query: 244 VRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLD 303 +I KV G +++K + + L Q RK + SP+A DLL+ Sbjct: 253 TQILKVTGVPGT-EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFP-----RASPQAADLLE 306 Query: 304 KLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNA 340 K+L D +RLTA +A+ HP+F P + + A Sbjct: 307 KMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQP 343 >3GC9-A nrPDB Length = 370 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 102/350 (29%), Positives = 173/350 (49%), Gaps = 39/350 (11%) Query: 1 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 60 M GP AG ++ E + W Q +R +G G Y V A + Sbjct: 7 MSGPRAG----------------FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDA 50 Query: 61 TNNERVVVKILKP-----VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVS----KTPA 111 ++V VK L + ++ RE+++L++L+ N+I L+D S Sbjct: 51 RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKH-ENVIGLLDVFTPATSIEDFSEVY 109 Query: 112 LVFEYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ 169 LV + D + Q L+D ++F +Y+LL+ L Y HS GI+HRD+KP NV ++ + Sbjct: 110 LVTTLM-GADLNNIVKSQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-ED 167 Query: 170 KKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR 229 +LR++D+GLA +E VA+R+++ PE+++++ Y+ ++D+WS+GC++A ++ Sbjct: 168 SELRILDFGLAR--QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQG 225 Query: 230 REPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSE 289 + F G D DQL RI +V+GT L K + + L +K + Sbjct: 226 KA-LFPGSDYIDQLKRIMEVVGTPSP-EVLAKISSEHARTYIQSLPPMPQKDLSSIFRGA 283 Query: 290 NRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADN 339 N P A+DLL ++L D QR++A EA+ H YF + +P A+ Sbjct: 284 N-----PLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEP 328 >2F9G-A nrPDB Length = 353 Score = 291 bits (745), Expect = 3e-79, Method: Composition-based stats. Identities = 91/325 (28%), Positives = 159/325 (48%), Gaps = 29/325 (8%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGGTN 94 D+QL LG G Y V A + E V +K ++P K + RE+KIL++ + N Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH-EN 70 Query: 95 IIKLIDTVKDPVSKT---PALVFEYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCH 149 II + + + + ++ E + TD ++ Q+L+D I++++Y+ L+A+ H Sbjct: 71 IITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA-----------QEYNVRVASRYF 198 ++HRD+KP N++I+ L++ D+GLA + VA+R++ Sbjct: 130 GSNVIHRDLKPSNLLINS-NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258 + PE+++ Y ++D+WS GC+LA + F R P F G+D QL+ I ++GT Sbjct: 189 RAPEVMLTSAKYSRAMDVWSCGCILAEL-FLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE 318 L+ + L + E V+P+ +DLL ++L +D +R+TAKE Sbjct: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFP-----RVNPKGIDLLQRMLVFDPAKRITAKE 302 Query: 319 AMEHPYFYPVVKEQSQPCADNAVLS 343 A+EHPY +P + S Sbjct: 303 ALEHPYLQTYHDPNDEPEGEPIPPS 327 >4IC8-A nrPDB Length = 442 Score = 290 bits (743), Expect = 5e-79, Method: Composition-based stats. Identities = 91/356 (25%), Positives = 170/356 (47%), Gaps = 28/356 (7%) Query: 2 PGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINIT 61 PGP A A V + ++ + ++ D+Y+++ +G G Y V A Sbjct: 20 PGPVKAEPAHTAASVAA-KNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRL 78 Query: 62 NNERVVVKILKP-----VKKKKIKREVKILENLRGGTNIIKLIDTVKDPV----SKTPAL 112 ++V +K + K+ RE+KIL++ + NII + D ++ V K+ + Sbjct: 79 TGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKH-DNIIAIKDILRPTVPYGEFKSVYV 137 Query: 113 VFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ 169 V + + +D Q+ Q LT +R+++Y+LL+ L Y HS ++HRD+KP N++++ + Sbjct: 138 VLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN-EN 195 Query: 170 KKLRLIDWGLAEFYHPAQE-----YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLA 224 +L++ D+G+A + VA+R+++ PEL++ Y ++D+WS+GC+ Sbjct: 196 CELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFG 255 Query: 225 SMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWEN 284 M+ RR+ F G++ QL I VLGT ++ + + L WE Sbjct: 256 EMLARRQ-LFPGKNYVHQLQLIMMVLGTPSP-AVIQAVGAERVRAYIQSLPPRQPVPWET 313 Query: 285 FIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNA 340 +R +AL LL ++LR++ R++A A+ HP+ +P Sbjct: 314 VYPGADR-----QALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPP 364 >4MVF-A nrPDB Length = 506 Score = 288 bits (738), Expect = 2e-78, Method: Composition-based stats. Identities = 78/320 (24%), Positives = 141/320 (44%), Gaps = 52/320 (16%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR---EVKILENLRGGT 93 +D Y + KLG+G Y V++ I+ N+ +K K + K I R E++I++ L Sbjct: 56 EDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKL-DHP 114 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHS 150 NI+KL +T ++ L+ E + + T+ + M ++ A+ Y HS Sbjct: 115 NIVKLYETYEN--DNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHS 172 Query: 151 KGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQ 208 I+HRD+KP N + + K L++ID+GL++ + + + Y+ P++L Sbjct: 173 LNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG-- 230 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 YD D+WS G ++ +++ PF+ DN E+ +KK Sbjct: 231 KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDN--------------EVLKKVKKGEF---- 272 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPV 328 + + +S +A +L+ KLL Y+ +R T +EA+ HP+ + Sbjct: 273 ----------------CFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQM 316 Query: 329 VKEQSQPCADNAVLSSGLTA 348 K ++ LSS L Sbjct: 317 TK-----SHEHVELSSTLLK 331 >3HZT-A nrPDB Length = 467 Score = 288 bits (737), Expect = 3e-78, Method: Composition-based stats. Identities = 81/327 (24%), Positives = 140/327 (42%), Gaps = 51/327 (15%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK------IKREVKILEN 88 G D YQ V+KLG G Y EV + +KI+K + EV +L+ Sbjct: 1 GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 60 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQ---LYQILTDFDIRFYMYELLKAL 145 L NI+KL + +D + LV E + L Q ++ D M ++L Sbjct: 61 L-DHPNIMKLYEFFED--KRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGT 117 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 Y H I+HRD+KP N++++ + + ++++D+GL+ + + R+ + Y+ PE+ Sbjct: 118 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV 177 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 L + YD D+WS G +L ++ PF GQ + + L R+ K Sbjct: 178 L--RKKYDEKCDVWSCGVILYILLCGYPPF-GGQTDQEILKRVEK-------------GK 221 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 DP + VS EA L+ +L Y+ +R++A+EA+ HP Sbjct: 222 FSFDP--------------------PDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHP 261 Query: 324 YFYPVVKEQSQPCADNAVLSSGLTAAR 350 + ++ +A L+ L + Sbjct: 262 WIVKFCSQKHTDVGKHA-LTGALGNMK 287 >6GU6-A nrPDB Length = 302 Score = 286 bits (733), Expect = 7e-78, Method: Composition-based stats. Identities = 85/309 (27%), Positives = 162/309 (52%), Gaps = 26/309 (8%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKILENL 89 G+ +DY + K+G G Y V++ + T + V +K ++ +++ RE+ +L+ L Sbjct: 4 GSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL 63 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY------QILTDFDIRFYMYELLK 143 R NI+ L D + L+FE+++ D K+ Q + ++ Y+Y++L+ Sbjct: 64 RH-PNIVSLQDVL--MQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 119 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPE 202 + +CHS+ ++HRD+KP N++ID + ++L D+GLA + P + Y V + +++ PE Sbjct: 120 GIVFCHSRRVLHRDLKPQNLLIDDK-GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 178 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 +L+ Y +D+WS+G + A + ++P FHG DQL RI + LGT + + Sbjct: 179 VLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 237 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 + +++ +W+ + + + LDLL K+L YD +R++ K A+ H Sbjct: 238 SLQ--------DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNH 289 Query: 323 PYFYPVVKE 331 PYF + + Sbjct: 290 PYFNDLDNQ 298 >3MA6-A nrPDB Length = 298 Score = 286 bits (732), Expect = 1e-77, Method: Composition-based stats. Identities = 77/306 (25%), Positives = 139/306 (45%), Gaps = 50/306 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP------VKKKKIKREVKILENLRG 91 D Y+ R LG+G + EV + + VK++ K+ + REV++L+ L Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL-D 90 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYC 148 NI+KL + +D LV E + + ++ D + ++L + Y Sbjct: 91 HPNIMKLYEFFED--KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYM 148 Query: 149 HSKGIMHRDVKPHNVMID--HQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVD 206 H I+HRD+KP N++++ + +R+ID+GL+ + +++ ++ + Y+ PE+L Sbjct: 149 HKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL-- 206 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 + YD D+WS G +L ++ PF +G + YD L ++ K T EL + K Sbjct: 207 HGTYDEKCDVWSTGVILYILLSGCPPF-NGANEYDILKKVEKGKYTFELPQWKK------ 259 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 VS A DL+ K+L Y R++A++A++H + Sbjct: 260 ---------------------------VSESAKDLIRKMLTYVPSMRISARDALDHEWIQ 292 Query: 327 PVVKEQ 332 KEQ Sbjct: 293 TYTKEQ 298 >5NGU-A nrPDB Length = 381 Score = 284 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 90/315 (28%), Positives = 162/315 (51%), Gaps = 23/315 (7%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGGTN 94 Y + +G G Y V A + N RV +K + P + + + RE+KIL R N Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRH-EN 101 Query: 95 IIKLIDTVKDPV---SKTPALVFEYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCH 149 II + D ++ P K +V + + TD +L Q L++ I +++Y++L+ L Y H Sbjct: 102 IIGINDIIRAPTIEQMKDVYIVQDLME-TDLYKLLKTQHLSNDHICYFLYQILRGLKYIH 160 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR----VASRYFKGPELLV 205 S ++HRD+KP N++++ L++ D+GLA P ++ VA+R+++ PE+++ Sbjct: 161 SANVLHRDLKPSNLLLNTT-CDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML 219 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 + + Y S+D+WS+GC+LA M+ R P F G+ DQL I +LG+ ++ Sbjct: 220 NSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 278 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 ++ L ++ W + + +ALDLLDK+L ++ +R+ ++A+ HPY Sbjct: 279 AR-NYLLSLPHKNKVPWNRLFPNAD-----SKALDLLDKMLTFNPHKRIEVEQALAHPYL 332 Query: 326 YPVVKEQSQPCADNA 340 +P A+ Sbjct: 333 EQYYDPSDEPIAEAP 347 >3DFA-A nrPDB Length = 286 Score = 284 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 74/304 (24%), Positives = 135/304 (44%), Gaps = 49/304 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREVKILENLRGG 92 + Y +V LG+G + EV + + + VK++ K I REV++L+ L Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL-DH 80 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCH 149 NI+KL + ++D S + +V E + + ++ D + ++ + Y H Sbjct: 81 PNIMKLFEILED--SSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH 138 Query: 150 SKGIMHRDVKPHNVMIDHQ--QKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 I+HRD+KP N++++ + +++ID+GL+ + + R+ + Y+ PE+L Sbjct: 139 KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG- 197 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 YD D+WS G +L ++ PF+ G++ YD L R+ KY DL Sbjct: 198 -TYDEKCDVWSAGVILYILLSGTPPFY-GKNEYDILKRVET-----------GKYAFDLP 244 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 +S +A DL+ K+L + R+TA + +EHP+ Sbjct: 245 ----------------------QWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQK 282 Query: 328 VVKE 331 E Sbjct: 283 YSSE 286 >4QTB-A nrPDB Length = 380 Score = 284 bits (727), Expect = 4e-77, Method: Composition-based stats. Identities = 87/315 (27%), Positives = 161/315 (51%), Gaps = 23/315 (7%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGGTN 94 Y ++ +G G Y V A + RV +K + P + + + RE++IL R N Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-EN 100 Query: 95 IIKLIDTVKDPV---SKTPALVFEYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCH 149 +I + D ++ + +V + + TD +L Q L++ I +++Y++L+ L Y H Sbjct: 101 VIGIRDILRASTLEAMRDVYIVQDLME-TDLYKLLKSQQLSNDHICYFLYQILRGLKYIH 159 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR----VASRYFKGPELLV 205 S ++HRD+KP N++I+ L++ D+GLA P ++ VA+R+++ PE+++ Sbjct: 160 SANVLHRDLKPSNLLINTT-CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 218 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 + + Y S+D+WS+GC+LA M+ R P F G+ DQL I +LG+ ++ Sbjct: 219 NSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 277 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 ++ L ++ W + +ALDLLD++L ++ +R+T +EA+ HPY Sbjct: 278 AR-NYLQSLPSKTKVAWAKLFPKSD-----SKALDLLDRMLTFNPNKRITVEEALAHPYL 331 Query: 326 YPVVKEQSQPCADNA 340 +P A+ Sbjct: 332 EQYYDPTDEPVAEEP 346 >6DTL-A nrPDB Length = 364 Score = 284 bits (727), Expect = 4e-77, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 154/307 (50%), Gaps = 22/307 (7%) Query: 43 VRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREVKILENLRGGTNIIK 97 + +G+G Y V A+N NE V +K + + K+ RE+K+L ++ NI+ Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVA 93 Query: 98 LIDTVKDPVSK---TPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSK 151 + D + P+ + +E ++ TD Q+ Q L++ ++++Y++L+ L Y HS Sbjct: 94 IRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSA 152 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYD 211 ++HRD+KP N++++ L++ D+GLA + V +R+++ PELL++ Y Sbjct: 153 NVLHRDLKPSNLLLNA-NCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYT 211 Query: 212 YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFN 271 ++D+WS+GC+ ++ R+ P F G+D+ QL + +++GT Sbjct: 212 AAIDVWSVGCIFMELMDRK-PLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR---- 266 Query: 272 DILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKE 331 + ++ V P A+DL++K+L +D ++R+T +A+ HPY + Sbjct: 267 ---YIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDI 323 Query: 332 QSQPCAD 338 +P Sbjct: 324 SDEPECT 330 >1JNK-A nrPDB Length = 423 Score = 284 bits (726), Expect = 4e-77, Method: Composition-based stats. Identities = 80/351 (22%), Positives = 156/351 (44%), Gaps = 18/351 (5%) Query: 10 ARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVK 69 A+ Y S +++ E ++ YQ ++ +G G V A + + V +K Sbjct: 34 AKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK 93 Query: 70 ILKP-----VKKKKIKREVKILENLRGGTNIIKLIDTVKD----PVSKTPALVFEYINNT 120 L K+ RE+ +++ NII L++ + LV E ++ Sbjct: 94 KLSRPFQNQTHAKRAYRELVLMK-CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN 152 Query: 121 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180 + + L + + +Y++L + + HS GI+HRD+KP N+++ L+++D+GLA Sbjct: 153 LCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLA 211 Query: 181 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240 + V +RY++ PE+++ Y ++D+WS+GC++ M+ R + F G+D Sbjct: 212 RTAGTSFMMTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMV-RHKILFPGRDYI 269 Query: 241 DQLVRIAKVLGTEELYGYLK-----KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS 295 DQ ++ + LGT K + +++ P + + SE+ L + Sbjct: 270 DQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKA 329 Query: 296 PEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGL 346 +A DLL K+L D +R++ +A++HPY + L Sbjct: 330 SQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQL 380 >3DXN-A nrPDB Length = 287 Score = 284 bits (726), Expect = 5e-77, Method: Composition-based stats. Identities = 78/309 (25%), Positives = 134/309 (43%), Gaps = 50/309 (16%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK------IKREVKILEN 88 G D YQ V+KLG G Y EV + +KI+K + EV +L+ Sbjct: 18 GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 77 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQ---LYQILTDFDIRFYMYELLKAL 145 L NI+KL + +D + LV E + L Q ++ D M ++L Sbjct: 78 L-DHPNIMKLYEFFED--KRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGT 134 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 Y H I+HRD+KP N++++ + + ++++D+GL+ + + R+ + Y+ PE+ Sbjct: 135 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV 194 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 L + YD D+WS G +L ++ PF GQ + + L R+ K Sbjct: 195 L--RKKYDEKCDVWSCGVILYILLCGYPPF-GGQTDQEILKRVEK-------------GK 238 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 DP + VS EA L+ +L Y+ +R++A+EA+ HP Sbjct: 239 FSFDP--------------------PDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHP 278 Query: 324 YFYPVVKEQ 332 + ++ Sbjct: 279 WIVKFCSQK 287 >1V0B-A nrPDB Length = 288 Score = 283 bits (725), Expect = 7e-77, Method: Composition-based stats. Identities = 91/301 (30%), Positives = 162/301 (53%), Gaps = 25/301 (8%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKILENLRG 91 + Y + K+G G Y V++A N E +K ++ K+ + RE+ IL+ L+ Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDY 147 NI+KL D + K LVFE+++ D K+L + L + ++ +LL + Y Sbjct: 60 S-NIVKLYDVIH--TKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAY 115 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELLVD 206 CH + ++HRD+KP N++I+ + +L++ D+GLA + P ++Y V + +++ P++L+ Sbjct: 116 CHDRRVLHRDLKPQNLLINRE-GELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMG 174 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 + Y ++D+WS+GC+ A M+ P F G DQL+RI ++LGT + + Sbjct: 175 SKKYSTTIDIWSVGCIFAEMVNGA-PLFPGVSEADQLMRIFRILGTPNSKNWPNVTEL-- 231 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 P ++ + WE+F+ + +DLL K+L+ D QR+TAK+A+EH YF Sbjct: 232 -PKYDPNFTVYEPLPWESFLKG-----LDESGIDLLSKMLKLDPNQRITAKQALEHAYFK 285 Query: 327 P 327 Sbjct: 286 E 286 >4KRC-A nrPDB Length = 317 Score = 283 bits (724), Expect = 9e-77, Method: Composition-based stats. Identities = 83/309 (26%), Positives = 161/309 (52%), Gaps = 23/309 (7%) Query: 34 WGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENL 89 + ++ + KLG G Y+ V++ +N T V +K +K ++ RE+ +++ L Sbjct: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---------QILTDFDIRFYMYE 140 + NI++L D + LVFE+++N D K+ + L ++++ ++ Sbjct: 61 KH-ENIVRLYDVIH--TENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFK 199 LL+ L +CH I+HRD+KP N++I+ ++ +L+L D+GLA + P ++ V + +++ Sbjct: 117 LLQGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 P++L+ + Y S+D+WS GC+LA MI + P F G ++ +QL I ++GT + Sbjct: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWP 234 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 + P +N + Q + + + + +D L LL+ + RL+AK+A Sbjct: 235 SVTKL---PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 Query: 320 MEHPYFYPV 328 + HP+F Sbjct: 292 LHHPWFAEY 300 >3LIJ-A nrPDB Length = 494 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 82/326 (25%), Positives = 155/326 (47%), Gaps = 50/326 (15%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----KKKIKREVKILENL 89 + YQ V+KLG G Y EV + + +KI++ K+ EV +L+ L Sbjct: 34 HLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLK-L 92 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFE-YINNTDFKQLYQIL--TDFDIRFYMYELLKALD 146 NI+KL D +D + LV E Y F ++ + + D + ++L + Sbjct: 93 LDHPNIMKLYDFFED--KRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVT 150 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL 204 Y H I+HRD+KP N++++ ++K ++++D+GL+ + ++ R+ + Y+ PE+L Sbjct: 151 YLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL 210 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 + YD D+WS+G +L ++ PF GQ + + L ++ K KY Sbjct: 211 --RKKYDEKCDVWSIGVILFILLAGYPPF-GGQTDQEILRKVEK-----------GKYTF 256 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 D W+N VS A DL+ ++L++D Q+R++A++A+EHP+ Sbjct: 257 D-------------SPEWKN---------VSEGAKDLIKQMLQFDSQRRISAQQALEHPW 294 Query: 325 FYPVVKEQSQPCADNAVLSSGLTAAR 350 + ++ + + L++ + R Sbjct: 295 IKEMCSKK-ESGIELPSLANAIENMR 319 >4ZSG-A nrPDB Length = 347 Score = 281 bits (718), Expect = 4e-76, Method: Composition-based stats. Identities = 85/326 (26%), Positives = 160/326 (49%), Gaps = 27/326 (8%) Query: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP-----VKKKKIKREVKIL 86 ++ D+Y+++ +G G Y V A ++V +K + K+ RE+KIL Sbjct: 1 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 60 Query: 87 ENLRGGTNIIKLIDTVKDPV----SKTPALVFEYINNTDFKQLY---QILTDFDIRFYMY 139 ++ + NII + D ++ V K+ +V + + +D Q+ Q LT +R+++Y Sbjct: 61 KHFKH-DNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLY 118 Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-----YNVRVA 194 +LL+ L Y HS ++HRD+KP N++++ + +L++ D+G+A + VA Sbjct: 119 QLLRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYVA 177 Query: 195 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE 254 +R+++ PEL++ Y ++D+WS+GC+ M+ RR+ F G++ QL I VLGT Sbjct: 178 TRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQ-LFPGKNYVHQLQLIMMVLGTPS 236 Query: 255 LYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL 314 ++ + + L WE +R +AL LL ++LR++ R+ Sbjct: 237 P-AVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADR-----QALSLLGRMLRFEPSARI 290 Query: 315 TAKEAMEHPYFYPVVKEQSQPCADNA 340 +A A+ HP+ +P Sbjct: 291 SAAAALRHPFLAKYHDPDDEPDCAPP 316 >3E7O-A nrPDB Length = 360 Score = 281 bits (718), Expect = 5e-76, Method: Composition-based stats. Identities = 78/344 (22%), Positives = 150/344 (43%), Gaps = 18/344 (5%) Query: 17 NSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP--- 73 S +++ + ++ YQ ++ +G G V A + V VK L Sbjct: 1 GSHMDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQ 60 Query: 74 --VKKKKIKREVKILENLRGGTNIIKLIDTVKD----PVSKTPALVFEYINNTDFKQLYQ 127 K+ RE+ +L+ NII L++ + LV E ++ + ++ Sbjct: 61 NQTHAKRAYRELVLLK-CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHM 119 Query: 128 ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ 187 L + + +Y++L + + HS GI+HRD+KP N+++ L+++D+GLA Sbjct: 120 ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTASTNF 178 Query: 188 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIA 247 V +RY++ PE+++ Y ++D+WS+GC++ ++ F G D+ DQ ++ Sbjct: 179 MMTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGELVKGSVIF-QGTDHIDQWNKVI 236 Query: 248 KVLGTEE-----LYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLL 302 + LGT + +++ P + I + W SE + + +A DLL Sbjct: 237 EQLGTPSAEFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLL 296 Query: 303 DKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGL 346 K+L D +R++ EA+ HPY + + L Sbjct: 297 SKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQL 340 >4AU8-A nrPDB Length = 296 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 90/304 (29%), Positives = 158/304 (51%), Gaps = 23/304 (7%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKILENLRGG 92 Y+ + K+G G Y VF+A N +E V +K ++ + RE+ +L+ L+ Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH- 64 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYC 148 NI++L D + K LVFE+ + D K+ + L ++ ++++LLK L +C Sbjct: 65 KNIVRLHDVLHS--DKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 121 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELLVDY 207 HS+ ++HRD+KP N++I+ + +L+L D+GLA + P + Y+ V + +++ P++L Sbjct: 122 HSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 180 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 ++Y S+DMWS GC+ A + P F G D DQL RI ++LGT + + Sbjct: 181 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL--- 237 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 P + + N + ++ DLL LL+ + QR++A+EA++HPYF Sbjct: 238 PDYKPYPMYPATTSLVNVVP-----KLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 292 Query: 328 VVKE 331 Sbjct: 293 FCPP 296 >4AGU-A nrPDB Length = 311 Score = 277 bits (710), Expect = 4e-75, Method: Composition-based stats. Identities = 84/306 (27%), Positives = 150/306 (49%), Gaps = 20/306 (6%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREVKILENLRG 91 + Y+ + K+G G Y VF+ N + V +K PV KK RE+++L+ L+ Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYC 148 N++ L++ + + LVFEY ++T + + + + + ++ ++ L+A+++C Sbjct: 62 -PNLVNLLEVFRR--KRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFC 118 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY-HPAQEYNVRVASRYFKGPELLVDY 207 H +HRDVKP N++I + ++L D+G A P+ Y+ VA+R+++ PELLV Sbjct: 119 HKHNCIHRDVKPENILIT-KHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGD 177 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 Y +D+W++GC+ A ++ P + G+ + DQL I K LG L H + Sbjct: 178 TQYGPPVDVWAIGCVFAELLSG-VPLWPGKSDVDQLYLIRKTLG------DLIPRHQQVF 230 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 G + +S AL LL L D +RLT ++ + HPYF Sbjct: 231 STNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFEN 290 Query: 328 VVKEQS 333 + + + Sbjct: 291 IREIED 296 >2XS0-A nrPDB Length = 386 Score = 277 bits (708), Expect = 5e-75, Method: Composition-based stats. Identities = 80/347 (23%), Positives = 152/347 (43%), Gaps = 18/347 (5%) Query: 14 AEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP 73 + S R ++ E ++ YQ ++ +G G V A + V +K L Sbjct: 2 SMSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSR 61 Query: 74 -----VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVS----KTPALVFEYINNTDFKQ 124 K+ RE+ +++ NII L++ S + +V E ++ + Sbjct: 62 PFQNQTHAKRAYRELVLMK-CVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQV 120 Query: 125 LYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH 184 + L + + +Y++L + + HS GI+HRD+KP N+++ L+++D+GLA Sbjct: 121 IQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAG 179 Query: 185 PAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLV 244 + V +RY++ PE+++ Y ++D+WS+GC++ MI F G D+ DQ Sbjct: 180 TSFMMVPFVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMIKGGV-LFPGTDHIDQWN 237 Query: 245 RIAKVLGTEELYGYLK-----KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEAL 299 ++ + LGT K + +++ P + + SE+ L + +A Sbjct: 238 KVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQAR 297 Query: 300 DLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGL 346 DLL K+L D +R++ EA++HPY + L Sbjct: 298 DLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQL 344 >3FI2-A nrPDB Length = 353 Score = 276 bits (707), Expect = 8e-75, Method: Composition-based stats. Identities = 77/325 (23%), Positives = 151/325 (46%), Gaps = 18/325 (5%) Query: 15 EVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP- 73 S +++ E ++ YQ ++ +G G V A + + V +K L Sbjct: 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 60 Query: 74 ----VKKKKIKREVKILENLRGGTNIIKLIDTVKD----PVSKTPALVFEYINNTDFKQL 125 K+ RE+ +++ NII L++ + LV E ++ + + Sbjct: 61 FQNQTHAKRAYRELVLMK-CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 119 Query: 126 YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP 185 L + + +Y++L + + HS GI+HRD+KP N+++ L+++D+GLA Sbjct: 120 QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGT 178 Query: 186 AQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR 245 + V +RY++ PE+++ Y ++D+WS+GC++ M+ R + F G+D DQ + Sbjct: 179 SFMMTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNK 236 Query: 246 IAKVLGTEELYGYLK-----KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300 + + LGT K + +++ P + + SE+ L + +A D Sbjct: 237 VIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARD 296 Query: 301 LLDKLLRYDHQQRLTAKEAMEHPYF 325 LL K+L D +R++ +A++HPY Sbjct: 297 LLSKMLVIDPAKRISVDDALQHPYI 321 >5FG8-A nrPDB Length = 285 Score = 276 bits (706), Expect = 9e-75, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 138/299 (46%), Gaps = 49/299 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-----KKIKREVKILENLRGG 92 D+Y + +LG+G +S V + + KI+ K +K++RE +I L Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKL-HH 72 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCH 149 NI++L D++++ LVF+ + + + + ++ D + ++L+++++CH Sbjct: 73 PNIVRLHDSIQE--ENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCH 130 Query: 150 SKGIMHRDVKPHNVMIDHQ--QKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVD 206 G++HRD+KP N+++ + ++L D+GLA E Q + + + PE+L Sbjct: 131 QNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL-K 189 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 + Y S+D+W+ G +L ++ PF+ + LY +K D Sbjct: 190 KEPYGKSVDIWACGVILYILLVGYPPFWDEDQH--------------RLYSQIKAGAYDY 235 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 S V+PEA +L++++L + +R+TA EA++HP+ Sbjct: 236 P--------------------SPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWI 274 >5AWM-A nrPDB Length = 394 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 79/334 (23%), Positives = 152/334 (45%), Gaps = 21/334 (6%) Query: 23 EYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP-----VKKK 77 +++ E ++ Y +R +G G V A + + V +K L K Sbjct: 29 QHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK 88 Query: 78 KIKREVKILENLRGGTNIIKLIDTVKDPVS----KTPALVFEYINNTDFKQLYQILTDFD 133 + RE K+++ L NII L++ + + LV E ++ + + L Sbjct: 89 RAYREFKLMK-LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDR 147 Query: 134 IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV 193 + + +Y++L + + HS GI+HRD+KP N+++ L+++D+GLA V Sbjct: 148 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA-DCTLKILDFGLARTAGTTFMMTPYV 206 Query: 194 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTE 253 +RY++ PE+++ Y ++D+WS+GC++ MI F G D+ DQ +I + LGT Sbjct: 207 VTRYYRAPEVILGM-GYTENVDIWSVGCIMGEMIRGGV-LFPGTDHIDQWNKIIEQLGTP 264 Query: 254 ------ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLR 307 L ++ Y + + + +++N + +A +LL K+L Sbjct: 265 SPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV 324 Query: 308 YDHQQRLTAKEAMEHPYF--YPVVKEQSQPCADN 339 D +QR++ EA++H Y + +E P + Sbjct: 325 IDPEQRISVDEALKHEYINVWYDAEEVDAPAPEP 358 >2BDW-A nrPDB Length = 362 Score = 275 bits (703), Expect = 2e-74, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 140/298 (46%), Gaps = 48/298 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-----KKIKREVKILENLRGG 92 D+Y + +LG+G +S V ++ T KI+ K +K++RE +I L+ Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH- 87 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCH 149 NI++L D++++ LVF+ + + + + ++ D + ++L+++ YCH Sbjct: 88 PNIVRLHDSIQE--ESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCH 145 Query: 150 SKGIMHRDVKPHNVMIDH--QQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 S GI+HR++KP N+++ + ++L D+GLA + ++ ++ + + PE+L Sbjct: 146 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL-KK 204 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 Y +D+W+ G +L ++ PF+ + LY +K D Sbjct: 205 DPYSKPVDIWACGVILYILLVGYPPFWDEDQH--------------RLYAQIKAGAYD-- 248 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 + W+ V+PEA L+D +L + ++R+TA +A++ P+ Sbjct: 249 ---------YPSPEWDT---------VTPEAKSLIDSMLTVNPKKRITADQALKVPWI 288 >2VN9-A nrPDB Length = 301 Score = 275 bits (703), Expect = 2e-74, Method: Composition-based stats. Identities = 76/299 (25%), Positives = 139/299 (46%), Gaps = 49/299 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----KKKIKREVKILENLRGG 92 D+YQL +LG+G +S V + I + KI+ K +K++RE +I L+ Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH- 62 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCH 149 NI++L D++ + LVF+ + + + + ++ D + ++L+++++CH Sbjct: 63 PNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH 120 Query: 150 SKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVD 206 GI+HRD+KP N+++ + K ++L D+GLA E Q + + + PE+L Sbjct: 121 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 Y +DMW+ G +L ++ PF+ + LY +K D Sbjct: 181 -DPYGKPVDMWACGVILYILLVGYPPFWDEDQH--------------RLYQQIKAGAYDF 225 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 S V+PEA DL++K+L + +R+TA EA++HP+ Sbjct: 226 P--------------------SPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 264 >5EFQ-A nrPDB Length = 347 Score = 274 bits (702), Expect = 3e-74, Method: Composition-based stats. Identities = 84/323 (26%), Positives = 158/323 (48%), Gaps = 30/323 (9%) Query: 33 SWGNQ--DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKI 85 WG + D + ++ +G G Y +V++A + E V +K ++ +K+ RE+KI Sbjct: 4 DWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKI 63 Query: 86 LENLRGGTNIIKLIDTVKDPVS--------KTPALVFEYINN---TDFKQLYQILTDFDI 134 L L + II + + V D LVFEY+++ + + I Sbjct: 64 LRQLTHQS-IINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 122 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE--YNVR 192 + +M +L++ LDYCH K +HRD+K N++++++ +++L D+GLA Y + Y + Sbjct: 123 KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNR-GQIKLADFGLARLYSSEESRPYTNK 181 Query: 193 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT 252 V + +++ PELL+ + Y ++D+WS GC+L + ++P F QL I+++ G+ Sbjct: 182 VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFT-KKPIFQANQELAQLELISRICGS 240 Query: 253 EELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQ 312 + + P+FN + + +R E + ALDL D +L D + Sbjct: 241 PCPAVWPDVIKL---PYFNTMKPKKQYRRKLR----EEFVFIPAAALDLFDYMLALDPSK 293 Query: 313 RLTAKEAMEHPYFYPVVKEQSQP 335 R TA++A++ + V + P Sbjct: 294 RCTAEQALQCEFLRDVEPSKMPP 316 >3Q5I-A nrPDB Length = 504 Score = 274 bits (700), Expect = 5e-74, Method: Composition-based stats. Identities = 78/334 (23%), Positives = 146/334 (43%), Gaps = 62/334 (18%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK----------------KKKIKR 81 + Y VRKLG G Y EV + +K++K + ++I Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95 Query: 82 EVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYM 138 E+ +L++L NIIKL D +D K LV E+ + + + D M Sbjct: 96 EISLLKSL-DHPNIIKLFDVFED--KKYFYLVTEFYEGGELFEQIINRHKFDECDAANIM 152 Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLAEFYHPAQEYNVRVASR 196 ++L + Y H I+HRD+KP N++++++ ++++D+GL+ F+ + R+ + Sbjct: 153 KQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTA 212 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY 256 Y+ PE+L + Y+ D+WS G ++ ++ PF GQ++ D + ++ K Sbjct: 213 YYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPF-GGQNDQDIIKKVEK-------- 261 Query: 257 GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA 316 KY+ D + + +S EA +L+ +L YD+ +R TA Sbjct: 262 ---GKYYFDFN----------------------DWKNISDEAKELIKLMLTYDYNKRCTA 296 Query: 317 KEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR 350 +EA+ + ++ +D L L+ R Sbjct: 297 EEALNSRWIKKYANNINK--SDQKTLCGALSNMR 328 >4YZB-A nrPDB Length = 491 Score = 273 bits (698), Expect = 9e-74, Method: Composition-based stats. Identities = 72/319 (22%), Positives = 139/319 (43%), Gaps = 51/319 (15%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKILENLRGG 92 D Y+ R LG+G + EV + + VK++ + K+ + + L Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDH 89 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCH 149 NI+KL + +D LV E + + ++ D + ++L + Y H Sbjct: 90 PNIMKLYEFFED--KGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMH 147 Query: 150 SKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 I+HRD+KP N+++++++K +R+ID+GL+ + ++ ++ + Y+ PE+L + Sbjct: 148 KNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVL--H 205 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 YD D+WS G +L ++ PF +G + +D L ++ K T +L + K Sbjct: 206 GTYDEKCDVWSTGVILYILLSGCPPF-NGANEFDILKKVEKGKFTFDLPQWKK------- 257 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 VS A DL+ K+L Y R++A++A+EH + Sbjct: 258 --------------------------VSEPAKDLIRKMLAYVPTMRISARDALEHEWLKT 291 Query: 328 V---VKEQSQPCADNAVLS 343 P ++ +L+ Sbjct: 292 TDAATDSIDVPSLESTILN 310 >4QNY-A nrPDB Length = 354 Score = 272 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 96/344 (27%), Positives = 166/344 (48%), Gaps = 41/344 (11%) Query: 4 PAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAIN-ITN 62 PA S A + AEV L D Y L R +G G Y V A + ++ Sbjct: 3 PATKSLAELQAEVCRLD-----------------DRYLLERIIGAGSYGVVIRARDTKSD 45 Query: 63 NERVVVKILKP------VKKKKIKREVKILENLRGGTNIIKLIDTV--KDPVS-KTPALV 113 N V +K + + K+I RE+K+L + NII L + + +DP + +V Sbjct: 46 NRLVAMKRVNKEIFEEVILAKRILREIKLLAHFND-DNIIGLRNILTPEDPENFDHFYIV 104 Query: 114 FEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQK 170 + + TD KQ+ Q LT+ I+F++Y+ L+AL HS G++HRD+ P N++++ Sbjct: 105 MDIME-TDLKQVLRSGQELTEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVNT-NC 162 Query: 171 KLRLIDWGLAEFYHP-AQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR 229 L++ D+GLA+ + + V R+++ PEL+++ + Y +D+W +GC+L ++ Sbjct: 163 DLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELL-G 221 Query: 230 REPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSE 289 P F G+D +QL +I V+GT + + + W + Sbjct: 222 SRPLFQGKDRVNQLDKIVDVIGTPS-EEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTA 280 Query: 290 NRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQS 333 SPEALDLL +L ++ ++R+T +AM HP+ + + Sbjct: 281 -----SPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHDDAD 319 >3KK8-A nrPDB Length = 284 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 138/298 (46%), Gaps = 48/298 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-----KKIKREVKILENLRGG 92 D+Y + +LG+G +S V ++ T KI+ K +K++RE +I L+ Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH- 64 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCH 149 NI++L D++++ LVF+ + + + + ++ D + ++L+++ YCH Sbjct: 65 PNIVRLHDSIQE--ESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCH 122 Query: 150 SKGIMHRDVKPHNVMIDH--QQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 S GI+HR++KP N+++ + ++L D+GLA + ++ ++ + + PE+L Sbjct: 123 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL-KK 181 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 Y +D+W+ G +L ++ PF+ + LY +K D Sbjct: 182 DPYSKPVDIWACGVILYILLVGYPPFWDEDQH--------------RLYAQIKAGAYDYP 227 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 S V+PEA L+D +L + ++R+TA +A++ P+ Sbjct: 228 --------------------SPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 265 >5AIR-A nrPDB Length = 430 Score = 271 bits (693), Expect = 3e-73, Method: Composition-based stats. Identities = 97/341 (28%), Positives = 158/341 (46%), Gaps = 25/341 (7%) Query: 4 PAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNN 63 P+A +V + + + P + Y + +G G + V++A + Sbjct: 30 PSAFGSMKVSIDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSG 89 Query: 64 ERVVVKILKPVKKKKIK-REVKILENLRGGTNIIKLIDTVKDPVSK----TPALVFEYIN 118 E V +K K ++ K+ K RE++I+ L NI++L K LV +Y+ Sbjct: 90 ELVAIK--KVLQDKRFKNRELQIMRKLDHC-NIVRLRYFFYSSGEKKDEVYLNLVLDYVP 146 Query: 119 NTDFK------QLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL 172 T ++ + Q L ++ YMY+L ++L Y HS GI HRD+KP N+++D L Sbjct: 147 ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL 206 Query: 173 RLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREP 232 +L D+G A+ + + SRY++ PEL+ Y S+D+WS GC+LA ++ + P Sbjct: 207 KLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ-P 265 Query: 233 FFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDI-LGQHSRKRWENFIHSENR 291 F G DQLV I KVLGT ++ +++P++ + Q W R Sbjct: 266 IFPGDSGVDQLVEIIKVLGTPT-----REQIREMNPNYTEFKFPQIKAHPWTKVF----R 316 Query: 292 HLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ 332 PEA+ L +LL Y RLT EA H +F + Sbjct: 317 PRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN 357 >3MIA-A nrPDB Length = 351 Score = 271 bits (693), Expect = 3e-73, Method: Composition-based stats. Identities = 91/340 (26%), Positives = 159/340 (46%), Gaps = 31/340 (9%) Query: 29 AHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREV 83 P Y+ + K+G+G + EVF+A + ++V +K + +K+ RE+ Sbjct: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREI 67 Query: 84 KILENLRGGTNIIKLIDTVK------DPVSKTPALVFEYINN---TDFKQLYQILTDFDI 134 KIL+ L+ N++ LI+ + + + LVF++ + + T +I Sbjct: 68 KILQLLKH-ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEI 126 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-----EY 189 + M LL L Y H I+HRD+K NV+I + L+L D+GLA + A+ Y Sbjct: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRY 185 Query: 190 NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKV 249 RV + +++ PELL+ + Y +D+W GC++A M R P G QL I+++ Sbjct: 186 TNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQL 244 Query: 250 LGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYD 309 G+ + + +L + GQ + + ++ P ALDL+DKLL D Sbjct: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVK-----DRLKAYVRDPYALDLIDKLLVLD 299 Query: 310 HQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAA 349 QR+ + +A+ H +F+ P +LS+ LT+ Sbjct: 300 PAQRIDSDDALNHDFFWS----DPMPSDLKGMLSTHLTSM 335 >4NST-A nrPDB Length = 351 Score = 271 bits (692), Expect = 4e-73, Method: Composition-based stats. Identities = 81/323 (25%), Positives = 159/323 (49%), Gaps = 30/323 (9%) Query: 33 SWGNQ--DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKI 85 WG + D + ++ +G G Y +V++A + E V +K ++ +K+ RE+KI Sbjct: 6 DWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKI 65 Query: 86 LENLRGGTNIIKLIDTVKDPVS--------KTPALVFEYINN---TDFKQLYQILTDFDI 134 L L + ++ + + V D LVFEY+++ + ++ I Sbjct: 66 LRQLIHRS-VVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 124 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE--YNVR 192 + +M +L++ L+YCH K +HRD+K N+++++ +++L D+GLA Y+ + Y + Sbjct: 125 KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNS-GQIKLADFGLARLYNSEESRPYTNK 183 Query: 193 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT 252 V + +++ PELL+ + Y ++D+WS GC+L + ++P F QL I+++ G+ Sbjct: 184 VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFT-KKPIFQANLELAQLELISRLCGS 242 Query: 253 EELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQ 312 + + P+FN + + +R E + ALDLLD +L D + Sbjct: 243 PCPAVWPDVIKL---PYFNTMKPKKQYRRRLR----EEFSFIPSAALDLLDHMLTLDPSK 295 Query: 313 RLTAKEAMEHPYFYPVVKEQSQP 335 R TA++ ++ + V + P Sbjct: 296 RCTAEQTLQSDFLKDVELSKMAP 318 >1UA2-A nrPDB Length = 346 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 93/328 (28%), Positives = 166/328 (50%), Gaps = 36/328 (10%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK--------REVKILENLR 90 Y+ + LG G+++ V++A + N+ V +K +K + + K RE+K+L+ L Sbjct: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL- 69 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKALD 146 NII L+D +LVF+++ TD + + + +LT I+ YM L+ L+ Sbjct: 70 SHPNIIGLLDAFGH--KSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY-HPAQEYNVRVASRYFKGPELLV 205 Y H I+HRD+KP+N+++D + L+L D+GLA+ + P + Y +V +R+++ PELL Sbjct: 127 YLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 +MY +DMW++GC+LA ++ R PF G + DQL RI + LGT Sbjct: 186 GARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTP------------ 232 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVS---PEALDLLDKLLRYDHQQRLTAKEAMEH 322 + + D+ +++F H+ S + LDL+ L ++ R+TA +A++ Sbjct: 233 TEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKM 292 Query: 323 PYFYPVVKEQSQPCADNAVLSSGLTAAR 350 YF + P + + + Sbjct: 293 KYFS--NRPGPTPGCQLPRPNCPVETLK 318 >2V7O-A nrPDB Length = 336 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 142/315 (45%), Gaps = 49/315 (15%) Query: 21 SREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK----- 75 E +++ DDYQL +LG+G +S V + T + KI+ K Sbjct: 14 GTENLYFQSMATCTRFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARD 73 Query: 76 KKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDF 132 +K++RE +I L+ NI++L D++ + LVF+ + + + + ++ Sbjct: 74 HQKLEREARICRLLKH-PNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAREYYSEA 130 Query: 133 DIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQ--QKKLRLIDWGLA-EFYHPAQEY 189 D ++++L+++++ H I+HRD+KP N+++ + ++L D+GLA E Q + Sbjct: 131 DASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAW 190 Query: 190 NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKV 249 + + PE+L Y +D+W+ G +L ++ PF+ + Sbjct: 191 FGFAGTPGYLSPEVLRK-DPYGKPVDIWACGVILYILLVGYPPFWDEDQH---------- 239 Query: 250 LGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYD 309 +LY +K D S V+PEA +L++++L + Sbjct: 240 ----KLYQQIKAGAYDFP--------------------SPEWDTVTPEAKNLINQMLTIN 275 Query: 310 HQQRLTAKEAMEHPY 324 +R+TA +A++HP+ Sbjct: 276 PAKRITADQALKHPW 290 >4NIF-A nrPDB Length = 333 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 86/320 (26%), Positives = 134/320 (41%), Gaps = 43/320 (13%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIK 97 D Y + +G G YSE ++ N VK++ K+ E++IL NII Sbjct: 8 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDP-SEEIEILLRYGQHPNIIT 66 Query: 98 LIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKGIM 154 L D D K LV E + + + ++ + F ++ + K ++Y HS+G++ Sbjct: 67 LKDVYDD--GKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 124 Query: 155 HRDVKPHNVMIDHQQKK---LRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELLVDYQMY 210 HRD+KP N++ + LR+ D+G A+ + F PE+L Q Y Sbjct: 125 HRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL-KRQGY 183 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 D D+WSLG +L +M+ PF +G + EE+ + L Sbjct: 184 DEGCDIWSLGILLYTMLAGYTPFANGPSDTP-----------EEILTRIGSGKFTL---- 228 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVK 330 N + VS A DL+ K+L D QRLTAK+ ++HP+ K Sbjct: 229 ----------------SGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDK 272 Query: 331 -EQSQPCADNAVLSSGLTAA 349 QSQ + L G AA Sbjct: 273 LPQSQLSHQDLQLVKGAMAA 292 >5U6Y-A nrPDB Length = 461 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 71/297 (23%), Positives = 135/297 (45%), Gaps = 49/297 (16%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----KKKIKREVKILENLRGGTN 94 YQL +LG+G +S V + + + KI+ K +K++RE +I L+ N Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH-PN 60 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSK 151 I++L D++ + L+F+ + + + + ++ D + ++L+A+ +CH Sbjct: 61 IVRLHDSISE--EGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 118 Query: 152 GIMHRDVKPHNVMIDHQ--QKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQ 208 G++HRD+KP N+++ + ++L D+GLA E Q + + + PE+L Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-D 177 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 Y +D+W+ G +L ++ PF+ + LY +K D Sbjct: 178 PYGKPVDLWACGVILYILLVGYPPFWDEDQH--------------RLYQQIKAGAYDFP- 222 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 S V+PEA DL++K+L + +R+TA EA++HP+ Sbjct: 223 -------------------SPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 260 >1G3N-A nrPDB Length = 326 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 85/330 (25%), Positives = 156/330 (47%), Gaps = 36/330 (10%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNN-ERVVVKILKPVKKKK-----IKREVKILENLR- 90 Y+ V ++G G Y +VF+A ++ N V +K ++ ++ REV +L +L Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 91 -GGTNIIKLIDTV---KDPVSKTPALVFEYINNTDFKQLYQILTD-----FDIRFYMYEL 141 N+++L D + LVFE+++ D + + I+ M++L Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 L+ LD+ HS ++HRD+KP N+++ +++L D+GLA Y V + +++ P Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSS-GQIKLADFGLARIYSFQMALTSVVVTLWYRAP 188 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 E+L+ Y +D+WS+GC+ A M FRR+P F G + DQL +I V+G + + Sbjct: 189 EVLLQSS-YATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 + S + E F+ + DLL K L ++ +R++A A+ Sbjct: 247 VALP-----RQAFHSKSAQPIEKFVT-----DIDELGKDLLLKCLTFNPAKRISAYSALS 296 Query: 322 HPYFYPVVKEQS------QPCADNAVLSSG 345 HPYF + + + P + + L++ Sbjct: 297 HPYFQDLERCKENLDSHLPPSQNTSELNTA 326 >2YCR-A nrPDB Length = 323 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 77/341 (22%), Positives = 139/341 (40%), Gaps = 64/341 (18%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK-----------KIKREVKI 85 +D+Y + + LG G EV A ++V +KI+ K ++ E++I Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68 Query: 86 LENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELL 142 L+ L IIK+ + ++ +V E + + + L + + Y Y++L Sbjct: 69 LKKL-NHPCIIKIKNFFD---AEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML 124 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDH--QQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 A+ Y H GI+HRD+KP NV++ + +++ D+G ++ + + Sbjct: 125 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 184 Query: 201 PELLVDYQ--MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258 PE+LV Y+ ++D WSLG +L + PF + L Sbjct: 185 PEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-------------SLKDQ 231 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE 318 + + P E VS +ALDL+ KLL D + R T +E Sbjct: 232 ITSGKYNFIP--------------------EVWAEVSEKALDLVKKLLVVDPKARFTTEE 271 Query: 319 AMEHPY---------FYPVVKEQSQPCADNAVLSSGLTAAR 350 A+ HP+ F ++ E+++ A VL+ T+ + Sbjct: 272 ALRHPWLQDEDMKRKFQDLLSEENESTAKPQVLAQPSTSRK 312 >4E7W-A nrPDB Length = 394 Score = 267 bits (683), Expect = 4e-72, Method: Composition-based stats. Identities = 95/305 (31%), Positives = 160/305 (52%), Gaps = 24/305 (7%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK-REVKILENLRGGTNIIKL 98 Y + +G G + VF+A + ++E V +K K ++ K+ K RE++I+ ++ N++ L Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIK--KVLQDKRFKNRELQIMRIVKH-PNVVDL 97 Query: 99 IDTVKDPVSKT----PALVFEYINNTDFK------QLYQILTDFDIRFYMYELLKALDYC 148 K LV EY+ T ++ +L Q + I+ YMY+LL++L Y Sbjct: 98 KAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYI 157 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQ 208 HS GI HRD+KP N+++D L+LID+G A+ + + SRY++ PEL+ Sbjct: 158 HSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGAT 217 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 Y ++D+WS GC++A ++ + P F G+ DQLV I KVLGT ++ ++P Sbjct: 218 NYTTNIDIWSTGCVMAELMQGQ-PLFPGESGIDQLVEIIKVLGTPS-----REQIKTMNP 271 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPV 328 ++ + R + R P+A+DL+ +LL Y RLTA EA+ HP+F + Sbjct: 272 NYMEHKFPQIRP---HPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDEL 328 Query: 329 VKEQS 333 ++ Sbjct: 329 RTGEA 333 >4BBM-A nrPDB Length = 331 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 84/302 (27%), Positives = 143/302 (47%), Gaps = 20/302 (6%) Query: 34 WGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREVKILEN 88 + + + Y+ + +G G Y V + N V +K + KK RE+K+L+ Sbjct: 21 FQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQ 80 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKAL 145 LR N++ L++ K K LVFE++++T D + L ++ Y+++++ + Sbjct: 81 LRH-ENLVNLLEVCKK--KKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGI 137 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELL 204 +CHS I+HRD+KP N+++ Q ++L D+G A P + Y+ VA+R+++ PELL Sbjct: 138 GFCHSHNIIHRDIKPENILVS-QSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELL 196 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 V Y ++D+W++GC++ M EP F G + DQL I LG L H Sbjct: 197 VGDVKYGKAVDVWAIGCLVTEMFMG-EPLFPGDSDIDQLYHIMMCLG------NLIPRHQ 249 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 +L G + E +S +DL K L D +R E + H + Sbjct: 250 ELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDF 309 Query: 325 FY 326 F Sbjct: 310 FQ 311 >2VZ6-A nrPDB Length = 313 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 72/300 (24%), Positives = 136/300 (45%), Gaps = 49/300 (16%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----KKKIKREVKILENLRG 91 Q YQL +LG+G +S V + + + KI+ K +K++RE +I L+ Sbjct: 21 QSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 80 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYC 148 NI++L D++ + L+F+ + + + + ++ D + ++L+A+ +C Sbjct: 81 -PNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 137 Query: 149 HSKGIMHRDVKPHNVMIDHQ--QKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLV 205 H G++HRD+KP N+++ + ++L D+GLA E Q + + + PE+L Sbjct: 138 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 197 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 Y +D+W+ G +L ++ PF+ + LY +K D Sbjct: 198 K-DPYGKPVDLWACGVILYILLVGYPPFWDEDQH--------------RLYQQIKAGAYD 242 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 S V+PEA DL++K+L + +R+TA EA++HP+ Sbjct: 243 FP--------------------SPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 282 >3BHH-A nrPDB Length = 295 Score = 266 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 137/298 (45%), Gaps = 49/298 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----KKKIKREVKILENLRGG 92 D+YQL +G+G +S V + + KI+ K +K++RE +I L+ Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCH 149 NI++L D++ + LVF+ + + + + ++ D + ++L+A+ +CH Sbjct: 64 -NIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 120 Query: 150 SKGIMHRDVKPHNVMIDH--QQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVD 206 G++HRD+KP N+++ + ++L D+GLA E Q + + + PE+L Sbjct: 121 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 + Y +D+W+ G +L ++ PF+ + +LY +K D Sbjct: 181 -EAYGKPVDIWACGVILYILLVGYPPFWDEDQH--------------KLYQQIKAGAYDF 225 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 S V+PEA +L++++L + +R+TA EA++HP+ Sbjct: 226 P--------------------SPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPW 263 >4RGJ-A nrPDB Length = 520 Score = 266 bits (679), Expect = 2e-71, Method: Composition-based stats. Identities = 70/325 (21%), Positives = 146/325 (44%), Gaps = 52/325 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENLRG 91 + Y+ ++ LG+G + EV + + +K++ + K+ + REV++L+ L Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKML-D 118 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYC 148 NI+KL + +D + LV + + + + D + ++L + Y Sbjct: 119 HINIMKLYEFFED--NNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYM 176 Query: 149 HSKGIMHRDVKPHNVMIDHQQKK---LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV 205 H ++HRD+KP N++++ + K+ +++ID+GL+ + +++ ++ + Y+ P++L Sbjct: 177 HKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVL- 235 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 + YD D+WS G +L ++ PF +G + YD L ++ KY D Sbjct: 236 -HGTYDEKCDIWSCGVILYILLSGCPPF-NGSNEYDILKKVE-----------AGKYTFD 282 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 L +S +A DL+ K+L Y R++A++A+EH + Sbjct: 283 LP----------------------QFKKISDKAKDLIKKMLMYTSAVRISARDALEHEWI 320 Query: 326 YPVVKEQSQPCADNAVLSSGLTAAR 350 + + + D L + R Sbjct: 321 KMMTSKDNL-NIDIPSLELSIANIR 344 >3SOA-A nrPDB Length = 444 Score = 265 bits (677), Expect = 2e-71, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 135/299 (45%), Gaps = 49/299 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVV-----KILKPVKKKKIKREVKILENLRGG 92 ++YQL +LG+G +S V + + + K L +K++RE +I L+ Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH- 69 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCH 149 NI++L D++ + L+F+ + + + + ++ D + ++L+A+ +CH Sbjct: 70 PNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 127 Query: 150 SKGIMHRDVKPHNVMIDHQ--QKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVD 206 G++HR++KP N+++ + ++L D+GLA E Q + + + PE+L Sbjct: 128 QMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK 187 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 Y +D+W+ G +L ++ PF+ + LY +K D Sbjct: 188 -DPYGKPVDLWACGVILYILLVGYPPFWDEDQH--------------RLYQQIKAGAYDF 232 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 S V+PEA DL++K+L + +R+TA EA++HP+ Sbjct: 233 P--------------------SPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 271 >5WAX-A nrPDB Length = 310 Score = 264 bits (675), Expect = 4e-71, Method: Composition-based stats. Identities = 67/302 (22%), Positives = 127/302 (42%), Gaps = 41/302 (13%) Query: 30 HVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILE 87 +P + D Y+LVR +G G + N + + V VK ++ +K + ++RE+ Sbjct: 3 DMPIMHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHR 62 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKA 144 +LR NII+ + + P A+V EY + + + ++ + RF+ +L+ Sbjct: 63 SLRH-PNIIRFKEVILTPT--HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISG 119 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQK-KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 + YCHS + HRD+K N ++D +L++ D+G ++ + V + + PE+ Sbjct: 120 VSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 179 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 L+ + D+WS G L M+ PF + + I ++LG + Sbjct: 180 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQ---------- 229 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 + +SPE DL+ ++ + R+T E HP Sbjct: 230 ----------------------YSIPDYVHISPECQDLISRIFVANPATRITIPEIRNHP 267 Query: 324 YF 325 +F Sbjct: 268 WF 269 >5IG1-A nrPDB Length = 344 Score = 264 bits (675), Expect = 4e-71, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 127/292 (43%), Gaps = 48/292 (16%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREVKILENLRGGTNIIKLI 99 +G+G +S V +N E VK++ + + KIKRE+ I +L+ +I+ + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQH-EHIVSMR 82 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKGIMHR 156 +D LVFEY++ + + + D M+++L AL +CHSK I+HR Sbjct: 83 RAFRD--ESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHR 140 Query: 157 DVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSL 214 D+KP N+++ + +++ D+GLA Y + + PE++ YD ++ Sbjct: 141 DLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRV-PYDTAV 199 Query: 215 DMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDIL 274 D+W+ G +L ++ PF+ ++LY +K D Sbjct: 200 DVWACGVILYILLVGYPPFWEEDH--------------QKLYAQIKNCQYDFP------- 238 Query: 275 GQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 S V+ A +L+ +L + ++R T +E ++HP+ Sbjct: 239 -------------SPEWDSVTTAAKELIKAMLEPNPKRRPTVQELLQHPWIA 277 >5Y86-A nrPDB Length = 588 Score = 264 bits (675), Expect = 4e-71, Method: Composition-based stats. Identities = 82/367 (22%), Positives = 165/367 (44%), Gaps = 50/367 (13%) Query: 3 GPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITN 62 GP A R V N+ + HVP Y++++ +G+G + +V + Sbjct: 172 GPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKL 231 Query: 63 NERVVVKILKPVKK--KKIKREVKILENLR-----GGTNIIKLIDTVKDPVSKTPALVFE 115 + V +K+++ K+ ++ E++ILE+L+ G N+I ++++ + FE Sbjct: 232 RQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESF--TFRNHVCMAFE 289 Query: 116 YINNTDFKQLYQI-----LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQK 170 ++ D +L + + +R + +L++LD H I+H D+KP N+++ H + Sbjct: 290 LLS-IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGR 348 Query: 171 -KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR 229 ++ID+G + F + Q+ + SR+++ PE+++ + Y +D+WS GC+LA ++ Sbjct: 349 SSTKVIDFGSSCFEY--QKLYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELLTG 405 Query: 230 REPFFHGQDNYDQLVRIAKVLG--TEELYGYLKKYHIDLD-------------------- 267 + P F G+D DQL + ++LG +L K+ ++ Sbjct: 406 Q-PLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVL 464 Query: 268 ----PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 G K W + + +L ++ L + L +D RLT +A+ HP Sbjct: 465 VGGRSRRGKKRGPPGSKDWGTALKGCDDYL----FIEFLKRCLHWDPSARLTPAQALRHP 520 Query: 324 YFYPVVK 330 + V Sbjct: 521 WISKSVP 527 >2JC6-A nrPDB Length = 334 Score = 264 bits (674), Expect = 5e-71, Method: Composition-based stats. Identities = 62/297 (20%), Positives = 120/297 (40%), Gaps = 47/297 (15%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV----KKKKIKREVKILENLRGGTNI 95 ++ LG G +SEV A + VK + K+ I+ E+ +L ++ NI Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKH-ENI 82 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKG 152 + L D + P LV + ++ + T+ D + ++L A+ Y H G Sbjct: 83 VALEDIYESP--NHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 140 Query: 153 IMHRDVKPHNVMI--DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 I+HRD+KP N++ ++ K+ + D+GL++ + + + PE+L + Y Sbjct: 141 IVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQ-KPY 199 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 ++D WS+G + ++ PF+ D+ +L+ + K + D + Sbjct: 200 SKAVDCWSIGVIAYILLCGYPPFYDENDS--------------KLFEQILKAEYEFDSPY 245 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 +S A D + L+ D +R T ++A HP+ Sbjct: 246 --------------------WDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAG 282 >2YAB-A nrPDB Length = 361 Score = 261 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 75/313 (23%), Positives = 133/313 (42%), Gaps = 53/313 (16%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK---------KKKIKREVKILE 87 +D Y + +LG G+++ V + + K +K + +++I+REV IL Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILR 70 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKA 144 + NII L D ++ L+ E ++ + + L++ + ++ ++L Sbjct: 71 QVLH-PNIITLHDVYENRTD--VVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQ---KKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 ++Y H+K I H D+KP N+M+ + ++LID+GLA E+ + F P Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 E +V+Y+ DMWS+G + ++ PF G + L I V Sbjct: 188 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAV------------ 233 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 D D F S A D + KLL + ++RLT +EA+ Sbjct: 234 -SYDFDEEF--------------------FSQTSELAKDFIRKLLVKETRKRLTIQEALR 272 Query: 322 HPYFYPVVKEQSQ 334 HP+ PV +Q+ Sbjct: 273 HPWITPVDTQQAM 285 >2A27-A nrPDB Length = 321 Score = 261 bits (667), Expect = 3e-70, Method: Composition-based stats. Identities = 75/313 (23%), Positives = 133/313 (42%), Gaps = 53/313 (16%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---------VKKKKIKREVKILE 87 +D Y + +LG G+++ V + + K +K V +++I+REV IL Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKA 144 + N+I L D ++ L+ E ++ + + L++ + ++ ++L Sbjct: 71 QVLHH-NVITLHDVYENRTD--VVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQ---KKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 ++Y H+K I H D+KP N+M+ + ++LID+GLA E+ + F P Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 E +V+Y+ DMWS+G + ++ PF G + L I V Sbjct: 188 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAV------------ 233 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 D D F S A D + KLL + ++RLT +EA+ Sbjct: 234 -SYDFDEEF--------------------FSQTSELAKDFIRKLLVKETRKRLTIQEALR 272 Query: 322 HPYFYPVVKEQSQ 334 HP+ PV +Q+ Sbjct: 273 HPWITPVDNQQAM 285 >2W4O-A nrPDB Length = 349 Score = 260 bits (665), Expect = 5e-70, Method: Composition-based stats. Identities = 73/293 (24%), Positives = 124/293 (42%), Gaps = 43/293 (14%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR-EVKILENLRGGTNII 96 D +++ +LGRG S V+ + +K+LK KKI R E+ +L L NII Sbjct: 53 DFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRL-SHPNII 111 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKGI 153 KL + + P +LV E + + ++ D + ++L+A+ Y H GI Sbjct: 112 KLKEIFETPTE--ISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGI 169 Query: 154 MHRDVKPHNVMIDH--QQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYD 211 +HRD+KP N++ L++ D+GL++ + + PE+L Y Sbjct: 170 VHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGC-AYG 228 Query: 212 YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFN 271 +DMWS+G + ++ EPF+ + + RI Sbjct: 229 PEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNC---------------------- 266 Query: 272 DILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 E + S VS A DL+ KL+ D ++RLT +A++HP+ Sbjct: 267 -----------EYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPW 308 >4JG6-A nrPDB Length = 355 Score = 260 bits (665), Expect = 6e-70, Method: Composition-based stats. Identities = 81/332 (24%), Positives = 135/332 (40%), Gaps = 44/332 (13%) Query: 27 YEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKIL 86 + H S D Y++ +G G YS I+ N VKI+ K+ + E++IL Sbjct: 24 QQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-EIEIL 82 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLK 143 NII L D D K +V E + + + ++ + ++ + K Sbjct: 83 LRYGQHPNIITLKDVYDD--GKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITK 140 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKK---LRLIDWGLAEFYH-PAQEYNVRVASRYFK 199 ++Y H++G++HRD+KP N++ + +R+ D+G A+ + F Sbjct: 141 TVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFV 200 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE+L + Q YD + D+WSLG +L +M+ PF +G D+ EE+ + Sbjct: 201 APEVL-ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTP-----------EEILARI 248 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 L + VS A DL+ K+L D QRLTA Sbjct: 249 GSGKFSL--------------------SGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALV 288 Query: 320 MEHPYF--YPVVKEQSQPCADNAVLSSGLTAA 349 + HP+ + + + D L G AA Sbjct: 289 LRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAA 320 >3GC0-A nrPDB Length = 329 Score = 260 bits (665), Expect = 6e-70, Method: Composition-based stats. Identities = 86/310 (27%), Positives = 158/310 (50%), Gaps = 25/310 (8%) Query: 29 AHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREV 83 + PS + D Y+ + KLG G Y EV++AI+ NE V +K ++ +++ REV Sbjct: 25 SAAPSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREV 84 Query: 84 KILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYE 140 +L+ L+ NII+L + + L+FEY N D K+ D I+ ++Y+ Sbjct: 85 SLLKELQH-RNIIELKSVIHH--NHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQ 140 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMID----HQQKKLRLIDWGLAEFYH-PAQEYNVRVAS 195 L+ +++CHS+ +HRD+KP N+++ + L++ D+GLA + P +++ + + Sbjct: 141 LINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIIT 200 Query: 196 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEEL 255 +++ PE+L+ + Y S+D+WS+ C+ A M+ + P F G DQL +I +VLG + Sbjct: 201 LWYRPPEILLGSRHYSTSVDIWSIACIWAEMLM-KTPLFPGDSEIDQLFKIFEVLGLPDD 259 Query: 256 YGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT 315 + + P + + K + + + +L D +R++ Sbjct: 260 TTWPG---VTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLT----AMLEMDPVKRIS 312 Query: 316 AKEAMEHPYF 325 AK A+EHPYF Sbjct: 313 AKNALEHPYF 322 >3PG1-A nrPDB Length = 362 Score = 260 bits (665), Expect = 6e-70, Method: Composition-based stats. Identities = 77/316 (24%), Positives = 146/316 (46%), Gaps = 31/316 (9%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL--------------KPVKKKKIKRE 82 Q Y + R + G Y V ++ V +K + K++ RE Sbjct: 21 QSPYTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLRE 79 Query: 83 VKILENLRGGTNIIKLIDTV---KDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIR 135 +++L + NI+ L D ++P LV E + TD Q+ +++ I+ Sbjct: 80 IRLLNHF-HHPNILGLRDIFVHFEEPAMHKLYLVTELM-RTDLAQVIHDQRIVISPQHIQ 137 Query: 136 FYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVAS 195 ++MY +L L H G++HRD+ P N+++ + + D+ LA V Sbjct: 138 YFMYHILLGLHVLHEAGVVHRDLHPGNILL-ADNNDITICDFNLAREDTADANKTHYVTH 196 Query: 196 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEEL 255 R+++ PEL++ ++ + +DMWS GC++A M R+ F G Y+QL +I +V+GT ++ Sbjct: 197 RWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKA-LFRGSTFYNQLNKIVEVVGTPKI 255 Query: 256 YGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT 315 + + + L + W + + + P ALDL+ K+L ++ Q+R++ Sbjct: 256 EDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTAD-----PVALDLIAKMLEFNPQRRIS 310 Query: 316 AKEAMEHPYFYPVVKE 331 ++A+ HPYF + Sbjct: 311 TEQALRHPYFESLFDP 326 >4FG9-A nrPDB Length = 320 Score = 260 bits (665), Expect = 6e-70, Method: Composition-based stats. Identities = 63/312 (20%), Positives = 126/312 (40%), Gaps = 51/312 (16%) Query: 29 AHVPSWGNQDD----YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIK 80 P W +D Y LG G +SEV A + + V +K + + ++ Sbjct: 5 VEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSME 64 Query: 81 REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFY 137 E+ +L ++ NI+ L D + L+ + ++ + T+ D Sbjct: 65 NEIAVLHKIKH-PNIVALDDIYES--GGHLYLIMQLVSGGELFDRIVEKGFYTERDASRL 121 Query: 138 MYELLKALDYCHSKGIMHRDVKPHNVMIDH--QQKKLRLIDWGLAEFYHPAQEYNVRVAS 195 ++++L A+ Y H GI+HRD+KP N++ + K+ + D+GL++ P + + Sbjct: 122 IFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGT 181 Query: 196 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEEL 255 + PE+L + Y ++D WS+G + ++ PF+ D +L Sbjct: 182 PGYVAPEVLAQ-KPYSKAVDCWSIGVIAYILLCGYPPFYDEND--------------AKL 226 Query: 256 YGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT 315 + + K + D + +S A D + L+ D ++R T Sbjct: 227 FEQILKAEYEFDSPY--------------------WDDISDSAKDFIRHLMEKDPEKRFT 266 Query: 316 AKEAMEHPYFYP 327 ++A++HP+ Sbjct: 267 CEQALQHPWIAG 278 >3F3Z-A nrPDB Length = 277 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 74/295 (25%), Positives = 128/295 (43%), Gaps = 47/295 (15%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKKIKREVKILENLRGGTNII 96 Y L +GRG + EV A+ R K + + K+E++I+++L NII Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSL-DHPNII 69 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKGI 153 +L +T +D LV E + + ++ + D M ++L A+ YCH + Sbjct: 70 RLYETFEDNTD--IYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNV 127 Query: 154 MHRDVKPHNVMI--DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYD 211 HRD+KP N + D L+LID+GLA + P + +V + Y+ P++L Y Sbjct: 128 AHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEGL--YG 185 Query: 212 YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFN 271 D WS G M+ ++ PF D+ + +++I + T Sbjct: 186 PECDEWSAGVMMYVLLCGYPPFSAPTDS-EVMLKIREGTFT------------------- 225 Query: 272 DILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 ++ VSP+A L+ +LL +QR+T+ +A+EH +F Sbjct: 226 --------------FPEKDWLNVSPQAESLIRRLLTKSPKQRITSLQALEHEWFE 266 >1ZWS-A nrPDB Length = 288 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 75/313 (23%), Positives = 133/313 (42%), Gaps = 53/313 (16%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---------VKKKKIKREVKILE 87 +D Y + +LG G+++ V + + K +K V +++I+REV IL Sbjct: 11 EDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKA 144 + N+I L D ++ L+ E ++ + + L++ + ++ ++L Sbjct: 71 QVLHH-NVITLHDVYENRTD--VVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQ---KKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 ++Y H+K I H D+KP N+M+ + ++LID+GLA E+ + F P Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAP 187 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 E +V+Y+ DMWS+G + ++ PF G + L I V Sbjct: 188 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITSV------------ 233 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 D D F S A D + KLL + ++RLT +EA+ Sbjct: 234 -SYDFDEEF--------------------FSHTSELAKDFIRKLLVKETRKRLTIQEALR 272 Query: 322 HPYFYPVVKEQSQ 334 HP+ PV +Q+ Sbjct: 273 HPWITPVDNQQAM 285 >4O2Z-A nrPDB Length = 377 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 77/337 (22%), Positives = 157/337 (46%), Gaps = 26/337 (7%) Query: 23 EYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-----K 77 ++ Y + Y L++ LG G Y ++ E+V +K + V + K Sbjct: 30 DFKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGK 89 Query: 78 KIKREVKILENLRGGTNIIKLIDTV-----KDPVSKTPALVFEYINNTDFKQLY---QIL 129 ++ RE+ ++ N++ +++ + + + +V ++ D + Q+L Sbjct: 90 RVLREIDMMR-FFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMD-VDMNVVLRSRQVL 147 Query: 130 TDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQE 188 + +++++Y++L+ L Y HS + HRD+KP N ++ + +L++ID+GL+ P E Sbjct: 148 EESHMQYFVYQILRGLKYLHSANVAHRDLKPAN-LVTNISCELKIIDFGLSRSVDVPYSE 206 Query: 189 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 V +R+++ PELL++ Y ++D+WS+GC+ A M + R+P F G++ DQL IA+ Sbjct: 207 LTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEM-YNRKPVFPGRNTMDQLRMIAQ 265 Query: 249 VLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRY 308 +G + ++ D + ++ E +D L K+ Sbjct: 266 HIGKPPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNT--------EGIDFLSKMWTL 317 Query: 309 DHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSG 345 D +R TA + + HPY + E+ +P L + Sbjct: 318 DPSKRPTAADMLAHPYLAHLHDEEDEPTCPCPFLWAH 354 >4BGQ-A nrPDB Length = 304 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 88/307 (28%), Positives = 152/307 (49%), Gaps = 22/307 (7%) Query: 31 VPSWGN-QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----KKKIKREVK 84 +P+ GN + ++++ +G G Y V + + +E V +K K + K+ RE+K Sbjct: 4 IPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELK 63 Query: 85 ILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYEL 141 +L L+ NI++L + + LVFEY+ + L ++ + ++ Y+Y+L Sbjct: 64 MLRTLKQ-ENIVELKEAFRR--RGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQL 120 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ--EYNVRVASRYFK 199 +KA+ +CH I+HRD+KP N++I H L+L D+G A Y+ VA+R+++ Sbjct: 121 IKAIHWCHKNDIVHRDIKPENLLISHND-VLKLCDFGFARNLSEGNNANYDEEVATRWYR 179 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PELL+ Y S+DMWS+GC+L + + P F G+ DQL I KVLG Sbjct: 180 SPELLLGA-PYGKSVDMWSVGCILGELSDGQ-PLFPGESEIDQLFTIQKVLGPLPSEQMK 237 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 Y +P F+ + + + +++ LDL+ LL+ D R ++ Sbjct: 238 LFYS---NPRFHGL--RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQC 292 Query: 320 MEHPYFY 326 + HP F Sbjct: 293 LNHPTFQ 299 >5G6V-A nrPDB Length = 324 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 83/301 (27%), Positives = 160/301 (53%), Gaps = 22/301 (7%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGG 92 + Y + KLG G Y+ V++ + + V +K ++ ++ REV +L++L+ Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 60 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY----QILTDFDIRFYMYELLKALDYC 148 NI+ L D + K+ LVFEY++ D KQ I+ +++ ++++LL+ L YC Sbjct: 61 -NIVTLHDIIH--TEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYC 116 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELLVDY 207 H + ++HRD+KP N++I+ ++ +L+L D+GLA P + Y+ V + +++ P++L+ Sbjct: 117 HRQKVLHRDLKPQNLLIN-ERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGS 175 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 Y +DMW +GC+ M R P F G +QL I ++LGT + Sbjct: 176 TDYSTQIDMWGVGCIFYEMATGR-PLFPGSTVEEQLHFIFRILGTPTEETWPGILS---- 230 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 N+ ++ ++ + + + DLL KLL+++ + R++A++AM+HP+F Sbjct: 231 ---NEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLS 287 Query: 328 V 328 + Sbjct: 288 L 288 >2J90-A nrPDB Length = 304 Score = 257 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 71/311 (22%), Positives = 134/311 (43%), Gaps = 53/311 (17%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---------VKKKKIKREVKILE 87 +D Y++ +LG G+++ V + + K +K V +++I+REV IL Sbjct: 25 EDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILR 84 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKA 144 +R NII L D ++ L+ E ++ + + LT+ + ++ ++L Sbjct: 85 EIRH-PNIITLHDIFENKTD--VVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDG 141 Query: 145 LDYCHSKGIMHRDVKPHNVMI---DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 201 + Y HSK I H D+KP N+M+ + +++LID+G+A E+ + F P Sbjct: 142 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAP 201 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 E +V+Y+ DMWS+G + ++ PF G+ + L I+ V Sbjct: 202 E-IVNYEPLGLEADMWSIGVITYILLSGASPFL-GETKQETLTNISAV------------ 247 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 + D D + S A D + +LL D ++R+T +++E Sbjct: 248 -NYDFDEEY--------------------FSNTSELAKDFIRRLLVKDPKRRMTIAQSLE 286 Query: 322 HPYFYPVVKEQ 332 H + + + Sbjct: 287 HSWIKAIRRRN 297 >3ZUT-A nrPDB Length = 362 Score = 257 bits (656), Expect = 7e-69, Method: Composition-based stats. Identities = 62/302 (20%), Positives = 126/302 (41%), Gaps = 41/302 (13%) Query: 30 HVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILE 87 +P + D Y+LV+ +G G + + +NE V VK ++ +K + +KRE+ Sbjct: 11 DLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHR 70 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKA 144 +LR NI++ + + P A+V EY + + + ++ + RF+ +L+ Sbjct: 71 SLRH-PNIVRFKEVILTPT--HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISG 127 Query: 145 LDYCHSKGIMHRDVKPHNVMID-HQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 + YCH+ + HRD+K N ++D +L++ +G ++ + V + + PE+ Sbjct: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEV 187 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 L+ + D+WS G L M+ PF ++ + I ++L + Sbjct: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ---------- 237 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 + +SPE L+ ++ D +R++ E H Sbjct: 238 ----------------------YAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHE 275 Query: 324 YF 325 +F Sbjct: 276 WF 277 >2Y7J-A nrPDB Length = 365 Score = 257 bits (656), Expect = 7e-69, Method: Composition-based stats. Identities = 75/322 (23%), Positives = 140/322 (43%), Gaps = 60/322 (18%) Query: 28 EAHVPSWGNQDD----YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-------- 75 E +P W + Y +GRG S V ++ VKI++ Sbjct: 80 EDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQL 139 Query: 76 ---KKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---IL 129 ++ +RE IL + G +II LID+ + S LVF+ + + L Sbjct: 140 EEVREATRRETHILRQVAGHPHIITLIDSYES--SSFMFLVFDLMRKGELFDYLTEKVAL 197 Query: 130 TDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY 189 ++ + R M LL+A+ + H+ I+HRD+KP N+++D ++RL D+G + P ++ Sbjct: 198 SEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLD-DNMQIRLSDFGFSCHLEPGEKL 256 Query: 190 NVRVASRYFKGPELL-----VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLV 244 + + PE+L + Y +D+W+ G +L +++ PF+H + Q++ Sbjct: 257 RELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRR----QIL 312 Query: 245 RIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDK 304 + ++ + Q S W++ S DL+ + Sbjct: 313 MLRMIM---------------------EGQYQFSSPEWDDR---------SSTVKDLISR 342 Query: 305 LLRYDHQQRLTAKEAMEHPYFY 326 LL+ D + RLTA++A++HP+F Sbjct: 343 LLQVDPEARLTAEQALQHPFFE 364 >3ZDU-A nrPDB Length = 325 Score = 257 bits (656), Expect = 7e-69, Method: Composition-based stats. Identities = 78/299 (26%), Positives = 145/299 (48%), Gaps = 19/299 (6%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI----KREVKILENLRG 91 + + Y+ + K+G G Y V + + + V +KI ++ + RE+K L+ Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQF-H 59 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYC 148 N++ LI+ + K LVFE+I++T + + L +R Y++++L+A+DY Sbjct: 60 HENLVNLIEVFRQ--KKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYL 117 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY-HPAQEYNVRVASRYFKGPELLVDY 207 HS I+HRD+KP N+++ Q +L D+G A P Y+ VA+R+++ PEL++ Sbjct: 118 HSNNIIHRDIKPENILVS-QSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKD 176 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 Y +D+W+LGCM+ M P+ + D L +I VL L +L+ Sbjct: 177 TSYGKPVDIWALGCMIIEMATG-NPYLPSSSDLDLLHKI--VLKVGNLSPHLQNIFSKSP 233 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 +L Q + + + L++ D++ L+ D R+++ + + H YF Sbjct: 234 IFAGVVLPQVQHPKNARKKYPKLNGLLA----DIVHACLQIDPADRISSSDLLHHEYFT 288 >3UC3-A nrPDB Length = 361 Score = 256 bits (655), Expect = 9e-69, Method: Composition-based stats. Identities = 62/302 (20%), Positives = 120/302 (39%), Gaps = 41/302 (13%) Query: 30 HVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK--KKKIKREVKILE 87 +P + D Y V+ +G G + + E V VK ++ + ++RE+ Sbjct: 12 DMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHR 71 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKA 144 +LR NI++ + + P A++ EY + + + ++ + RF+ +LL Sbjct: 72 SLRH-PNIVRFKEVILTPT--HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSG 128 Query: 145 LDYCHSKGIMHRDVKPHNVMID-HQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 + YCHS I HRD+K N ++D +L++ D+G ++ + V + + PE+ Sbjct: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 L+ + D+WS G L M+ PF ++ D I ++L + Sbjct: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK---------- 238 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 + +SPE L+ ++ D R++ E H Sbjct: 239 ----------------------YSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHS 276 Query: 324 YF 325 +F Sbjct: 277 WF 278 >1PHK-A nrPDB Length = 298 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 73/318 (22%), Positives = 134/318 (42%), Gaps = 57/318 (17%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK------------KKKIKRE 82 G ++Y+ LGRG S V I+ + VKI+ ++ +E Sbjct: 14 GFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKE 73 Query: 83 VKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMY 139 V IL + G NII+L DT + + LVF+ + + L++ + R M Sbjct: 74 VDILRKVSGHPNIIQLKDTYE--TNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMR 131 Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK 199 LL+ + H I+HRD+KP N+++D ++L D+G + P ++ + + Sbjct: 132 ALLEVICALHKLNIVHRDLKPENILLD-DDMNIKLTDFGFSCQLDPGEKLREVCGTPSYL 190 Query: 200 GPELLV-----DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE 254 PE++ ++ Y +DMWS G ++ +++ PF+H + Q++ + ++ Sbjct: 191 APEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRK----QMLMLRMIM---- 242 Query: 255 LYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL 314 Q W+++ S DL+ + L Q+R Sbjct: 243 -----------------SGNYQFGSPEWDDY---------SDTVKDLVSRFLVVQPQKRY 276 Query: 315 TAKEAMEHPYFYPVVKEQ 332 TA+EA+ HP+F V E+ Sbjct: 277 TAEEALAHPFFQQYVVEE 294 >3E3P-A nrPDB Length = 360 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 86/312 (27%), Positives = 155/312 (49%), Gaps = 26/312 (8%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK-REVKILENLR--GGT 93 D +Q+ R G+G + V + V +K K ++ + + RE++I+++L Sbjct: 22 MDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIK--KVIQDPRFRNRELQIMQDLAVLHHP 79 Query: 94 NIIKLIDTV-----KDPVSKTPALVFEYINNT------DFKQLYQILTDFDIRFYMYELL 142 NI++L +D +V EY+ +T ++ + I+ ++++L+ Sbjct: 80 NIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLI 139 Query: 143 KALDYCH--SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 +++ H S + HRD+KPHNV+++ L+L D+G A+ P++ + SRY++ Sbjct: 140 RSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYRA 199 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK 260 PEL+ Q Y ++D+WS+GC+ A M+ EP F G ++ QL I +VLG + Sbjct: 200 PELIFGNQHYTTAVDIWSVGCIFAEMMLG-EPIFRGDNSAGQLHEIVRVLGCPS-----R 253 Query: 261 KYHIDLDPHFNDI-LGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 + L+P D+ L W N S++ + EA DLL LL+Y ++R+ EA Sbjct: 254 EVLRKLNPSHTDVDLYNSKGIPWSNVF-SDHSLKDAKEAYDLLSALLQYLPEERMKPYEA 312 Query: 320 MEHPYFYPVVKE 331 + HPYF + Sbjct: 313 LCHPYFDELHDP 324 >2JAM-A nrPDB Length = 304 Score = 256 bits (653), Expect = 1e-68, Method: Composition-based stats. Identities = 59/303 (19%), Positives = 126/303 (41%), Gaps = 47/303 (15%) Query: 31 VPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV---KKKKIKREVKILE 87 + + + + + LG G +SEVF + +K +K + ++ E+ +L+ Sbjct: 2 MQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLK 61 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKA 144 ++ NI+ L D + LV + ++ + + T+ D + ++L A Sbjct: 62 KIKH-ENIVTLEDIYESTT--HYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSA 118 Query: 145 LDYCHSKGIMHRDVKPHNVMI--DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 202 + Y H GI+HRD+KP N++ + K+ + D+GL++ + + + PE Sbjct: 119 VKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG-IMSTACGTPGYVAPE 177 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 +L + Y ++D WS+G + ++ PF+ ++ +L+ +K+ Sbjct: 178 VLAQ-KPYSKAVDCWSIGVITYILLCGYPPFYEETES--------------KLFEKIKEG 222 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 + + + F +S A D + LL D +R T ++A+ H Sbjct: 223 YYEFESPF--------------------WDDISESAKDFICHLLEKDPNERYTCEKALSH 262 Query: 323 PYF 325 P+ Sbjct: 263 PWI 265 >5YKS-A nrPDB Length = 377 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 67/304 (22%), Positives = 131/304 (43%), Gaps = 50/304 (16%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI-----KREVKILENLRGGTN 94 Y L + LGRG ++ V A ++ E+V VK++ K + +EV+ ++ L N Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMK-LVQHPN 95 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDF----KQLYQILTDFDIRFYMYELLKALDYCHS 150 I++L + + L+ E + D + + L + + Y +++ A+ YCH Sbjct: 96 IVRLYEVI--DTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHK 153 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 ++HRD+KP NV+ +Q ++L D+G + + P ++ S + PE+L+ + Sbjct: 154 LHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYD 213 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 ++D+WSLG +L ++ + PF ++ + L I T + Sbjct: 214 APAVDIWSLGVILFMLVCGQPPF-QEANDSETLTMIMDCKYTVPSH-------------- 258 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVK 330 VS E DL+ ++L+ D ++R + +E HP+ V Sbjct: 259 -----------------------VSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDP 295 Query: 331 EQSQ 334 + Sbjct: 296 SPAT 299 >3MN3-A nrPDB Length = 271 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 73/305 (23%), Positives = 131/305 (42%), Gaps = 50/305 (16%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENLRGG 92 +YQ+V+ LG G + +V A + T ++V +KI+ K + +I+RE+ L LR Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRH- 63 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDYCHS 150 +IIKL D +K +V EY N F + Q +++ + R + +++ A++YCH Sbjct: 64 PHIIKLYDVIKS--KDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHR 121 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 I+HRD+KP N+++D + +++ D+GL+ S + PE++ Sbjct: 122 HKIVHRDLKPENLLLD-EHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYA 180 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 +D+WS G +L M+ RR PF L+ + L Sbjct: 181 GPEVDVWSCGVILYVMLCRRLPFDDES--------------IPVLFKNISNGVYTLP--- 223 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVK 330 +SP A L+ ++L + R++ E M+ +F + Sbjct: 224 ---------------------KFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVDLP 262 Query: 331 EQSQP 335 E P Sbjct: 263 EYLLP 267 >1NY3-A nrPDB Length = 400 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 75/315 (23%), Positives = 130/315 (41%), Gaps = 43/315 (13%) Query: 38 DDYQLV-RKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNII 96 DDY++ + LG G +V + N E+ +K+L K +REV++ +I+ Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 118 Query: 97 KLIDTVKD--PVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKALDYCH 149 +++D ++ K +V E ++ + Q T+ + M + +A+ Y H Sbjct: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 Query: 150 SKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 S I HRDVKP N++ ++ L+L D+G A+ + Y+ PE+L Sbjct: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 237 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 + YD S DMWSLG ++ ++ PF+ + + I+ + T G + Sbjct: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYS-----NHGLAISPGMKTRIRMGQYE------- 285 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 + VS E L+ LL+ + QR+T E M HP+ Sbjct: 286 ------------------FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 Query: 328 VVKEQSQPCADNAVL 342 K P + VL Sbjct: 328 STKVPQTPLHTSRVL 342 >3UTO-A nrPDB Length = 573 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 69/337 (20%), Positives = 135/337 (40%), Gaps = 50/337 (14%) Query: 22 REYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKK 78 ++Y+ + D Y + +LG G + V K + K+ Sbjct: 141 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKET 200 Query: 79 IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDF----KQLYQILTDFDI 134 +++E++ + LR ++ L D +D +++E+++ + + +++ + Sbjct: 201 VRKEIQTMSVLRH-PTLVNLHDAFED--DNEMVMIYEFMSGGELFEKVADEHNKMSEDEA 257 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ-KKLRLIDWGLAEFYHPAQEYNVRV 193 YM ++ K L + H +H D+KP N+M ++ +L+LID+GL P Q V Sbjct: 258 VEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT 317 Query: 194 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTE 253 + F PE+ + + Y DMWS+G + ++ PF G+++ + L + Sbjct: 318 GTAEFAAPEV-AEGKPVGYYTDMWSVGVLSYILLSGLSPF-GGENDDETLRNV------- 368 Query: 254 ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR 313 K + + +S + D + KLL D R Sbjct: 369 --------------------------KSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTR 402 Query: 314 LTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR 350 +T +A+EHP+ P + P D+ + SS T R Sbjct: 403 MTIHQALEHPWLTP----GNAPGRDSQIPSSRYTKIR 435 >3TAC-A nrPDB Length = 361 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 73/309 (23%), Positives = 136/309 (44%), Gaps = 57/309 (18%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK--------KKKIKREVKILEN 88 +D Y+L +G+G +S V IN ++ VKI+ K + +KRE I Sbjct: 25 EDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHM 84 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFK-QLYQ------ILTDFDIRFYMYEL 141 L+ +I++L++T +VFE+++ D ++ + + ++ YM ++ Sbjct: 85 LKH-PHIVELLETYSS--DGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQI 141 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLA-EFYHPAQEYNVRVASRYF 198 L+AL YCH I+HRDVKPH V++ ++ ++L +G+A + RV + +F Sbjct: 142 LEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHF 201 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258 PE++ + Y +D+W G +L ++ PF+ + E L+ Sbjct: 202 MAPEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYGTK---------------ERLFEG 245 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE 318 + K ++P +S A DL+ ++L D +R+T E Sbjct: 246 IIKGKYKMNPR--------------------QWSHISESAKDLVRRMLMLDPAERITVYE 285 Query: 319 AMEHPYFYP 327 A+ HP+ Sbjct: 286 ALNHPWLKE 294 >3RP9-A nrPDB Length = 458 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 95/406 (23%), Positives = 162/406 (39%), Gaps = 78/406 (19%) Query: 5 AAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE 64 +GS+ S+ W D Y++ +G G Y V EA + Sbjct: 20 VSGSQQEGQQRKQHHSSKPTASMPRPHSDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKR 79 Query: 65 RVVVKIL-----KPVKKKKIKREVKILENLRGGTNIIKLIDTVKD---PVSKTPALVFEY 116 V +K + + K+I RE+ IL L +++K++D V +V E Sbjct: 80 VVAIKKILRVFEDLIDCKRILREIAILNRL-NHDHVVKVLDIVIPKDVEKFDELYVVLE- 137 Query: 117 INNTDFKQLYQI---LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLR 173 I ++DFK+L++ LT+ I+ +Y LL + Y HS GI+HRD+KP N +++ Q ++ Sbjct: 138 IADSDFKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVN-QDCSVK 196 Query: 174 LIDWGLAEFYHP----------------------------AQEYNVRVASRYFKGPELLV 205 + D+GLA ++ V +R+++ PEL++ Sbjct: 197 VCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELIL 256 Query: 206 DYQMYDYSLDMWSLGCMLASMI----------FRREPFFHGQD----------------- 238 + Y ++D+WS+GC+ A ++ R P F G Sbjct: 257 LQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPGSSCFPLSPDQKAGNDFKFH 316 Query: 239 ---NYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS 295 N DQL I +LGT D + + E F S S Sbjct: 317 TRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIFPKREGTDLAERFPAS------S 370 Query: 296 PEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAV 341 +A+ LL ++L ++ +R+T E + HP+F V + + A V Sbjct: 371 ADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRIAEVETNATEKV 416 >2OZA-A nrPDB Length = 356 Score = 254 bits (649), Expect = 5e-68, Method: Composition-based stats. Identities = 75/315 (23%), Positives = 130/315 (41%), Gaps = 43/315 (13%) Query: 38 DDYQLV-RKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNII 96 DDY++ + LG G +V + N E+ +K+L K +REV++ +I+ Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 74 Query: 97 KLIDTVKD--PVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKALDYCH 149 +++D ++ K +V E ++ + Q T+ + M + +A+ Y H Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 150 SKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 S I HRDVKP N++ ++ L+L D+G A+ + Y+ PE+L Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 193 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 + YD S DMWSLG ++ ++ PF+ + + I+ + T G + Sbjct: 194 EKYDKSCDMWSLGVIMYILLCGYPPFYS-----NHGLAISPGMKTRIRMGQYE------- 241 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 + VS E L+ LL+ + QR+T E M HP+ Sbjct: 242 ------------------FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 283 Query: 328 VVKEQSQPCADNAVL 342 K P + VL Sbjct: 284 STKVPQTPLHTSRVL 298 >3UDB-A nrPDB Length = 317 Score = 254 bits (648), Expect = 5e-68, Method: Composition-based stats. Identities = 62/302 (20%), Positives = 125/302 (41%), Gaps = 41/302 (13%) Query: 30 HVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILE 87 +P + D Y+LV+ +G G + + NE V VK ++ +K + +KRE+ Sbjct: 11 DLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREIINHR 70 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKA 144 +LR NI++ + + P A+V EY + + + ++ + RF+ +L+ Sbjct: 71 SLRH-PNIVRFKEVILTPT--HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISG 127 Query: 145 LDYCHSKGIMHRDVKPHNVMID-HQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 + Y H+ + HRD+K N ++D +L++ D+G ++ + V + + PE+ Sbjct: 128 VSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEV 187 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 L+ + D+WS G L M+ PF ++ + I ++L + Sbjct: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQ---------- 237 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 + +SPE L+ ++ D +R++ E H Sbjct: 238 ----------------------YAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHE 275 Query: 324 YF 325 +F Sbjct: 276 WF 277 >3I6U-A nrPDB Length = 419 Score = 254 bits (648), Expect = 5e-68, Method: Composition-based stats. Identities = 70/309 (22%), Positives = 125/309 (40%), Gaps = 55/309 (17%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK-----------KIKREVKI 85 +D+Y + + LG G EV A ++V ++I+ K ++ E++I Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEI 193 Query: 86 LENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELL 142 L+ L IIK+ + ++ +V E + + + L + + Y Y++L Sbjct: 194 LKKL-NHPCIIKIKNFFD---AEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML 249 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDH--QQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 A+ Y H GI+HRD+KP NV++ + +++ D+G ++ + + Sbjct: 250 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 309 Query: 201 PELLVDYQ--MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258 PE+LV Y+ ++D WSLG +L + PF + L Sbjct: 310 PEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-------------SLKDQ 356 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE 318 + + P E VS +ALDL+ KLL D + R T +E Sbjct: 357 ITSGKYNFIP--------------------EVWAEVSEKALDLVKKLLVVDPKARFTTEE 396 Query: 319 AMEHPYFYP 327 A+ HP+ Sbjct: 397 ALRHPWLQD 405 >5XZW-A nrPDB Length = 471 Score = 254 bits (648), Expect = 5e-68, Method: Composition-based stats. Identities = 72/316 (22%), Positives = 127/316 (40%), Gaps = 58/316 (18%) Query: 33 SWGNQDDYQLV-RKLGRGKYSEVFEAINITNNERVVVKILKPVKK----KKIKREVKILE 87 G D+ ++ +G+G ++ V +AI T + VKI+ K + RE+++L+ Sbjct: 190 KTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQ 249 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL---YQILTDFDIRFYMYELLKA 144 L I++L +D S +V E+++ D + + + R ++L A Sbjct: 250 KL-NHPRIVRLKGFYEDTES--YYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTA 306 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKK-LRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 + Y HS GI HRD+KP N++I+ +++ D+GLA+ + + PE+ Sbjct: 307 IKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEV 366 Query: 204 LVDYQM------------YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG 251 + Y +DMWS+GC++ ++ PF DQL Sbjct: 367 IRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF--SGSTQDQL-------- 416 Query: 252 TEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQ 311 Y + + P +S EA D +D LL+ D Sbjct: 417 ----YKQIGRGSYHEGP--------------------LKDFRISEEARDFIDSLLQVDPN 452 Query: 312 QRLTAKEAMEHPYFYP 327 R TA +A+ HP+ Sbjct: 453 NRSTAAKALNHPWIVD 468 >2HW6-A nrPDB Length = 307 Score = 254 bits (648), Expect = 6e-68, Method: Composition-based stats. Identities = 79/319 (24%), Positives = 140/319 (43%), Gaps = 46/319 (14%) Query: 37 QDDYQLV-RKLGRGKYSEVFEAINITNNERVVVKILKPV---KKKKIKREVKILENLRGG 92 +D Y+L LG G Y++V A+++ N + VKI++ + ++ REV+ L +G Sbjct: 11 EDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGN 70 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYCH 149 NI++LI+ +D LVFE + Q + + + ++ ALD+ H Sbjct: 71 KNILELIEFFEDDTR--FYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH 128 Query: 150 SKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYH--------PAQEYNVRVASRYFK 199 +KGI HRD+KP N++ + +K +++ D+ L E S + Sbjct: 129 TKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM 188 Query: 200 GPELLV----DYQMYDYSLDMWSLGCMLASMIFRREPFFH--GQDNYDQLVRIAKVLGTE 253 PE++ YD D+WSLG +L M+ PF G D + +V Sbjct: 189 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRV-CQN 247 Query: 254 ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR 313 +L+ +++ + ++ +S EA DL+ KLL D +QR Sbjct: 248 KLFESIQEGKYEFP--------------------DKDWAHISSEAKDLISKLLVRDAKQR 287 Query: 314 LTAKEAMEHPYFYPVVKEQ 332 L+A + ++HP+ E+ Sbjct: 288 LSAAQVLQHPWVQGQAPEK 306 >3KA0-A nrPDB Length = 320 Score = 254 bits (648), Expect = 6e-68, Method: Composition-based stats. Identities = 75/315 (23%), Positives = 130/315 (41%), Gaps = 43/315 (13%) Query: 38 DDYQLV-RKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNII 96 DDY++ + LG G +V + N E+ +K+L K +REV++ +I+ Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 72 Query: 97 KLIDTVKD--PVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKALDYCH 149 +++D ++ K +V E ++ + Q T+ + M + +A+ Y H Sbjct: 73 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 132 Query: 150 SKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 S I HRDVKP N++ ++ L+L D+G A+ + Y+ PE+L Sbjct: 133 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVL-GP 191 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 + YD S DMWSLG ++ ++ PF+ + + I+ + T G + Sbjct: 192 EKYDKSCDMWSLGVIMYILLCGYPPFYS-----NHGLAISPGMKTRIRMGQYE------- 239 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 + VS E L+ LL+ + QR+T E M HP+ Sbjct: 240 ------------------FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 281 Query: 328 VVKEQSQPCADNAVL 342 K P + VL Sbjct: 282 STKVPQTPLHTSRVL 296 >5ES1-A nrPDB Length = 328 Score = 254 bits (648), Expect = 6e-68, Method: Composition-based stats. Identities = 68/311 (21%), Positives = 138/311 (44%), Gaps = 51/311 (16%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREVKILENLRGGT 93 +Y+L+R +G+G +++V A +I V +KI+ P +K+ REV+I++ L Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGL-NHP 74 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYCHS 150 NI+KL + ++ KT LV EY + D+ + + + + R +++ A+ YCH Sbjct: 75 NIVKLFEVIE--TEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQ 132 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 K I+HRD+K N+++D + +++ D+G + + + + S + PEL + Sbjct: 133 KNIVHRDLKAENLLLDAE-ANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYD 191 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 +D+WSLG +L +++ PF G + + R+ + KY + Sbjct: 192 GPEVDIWSLGVILYTLVSGSLPF-DGHNLKELRERVLR-----------GKYRVPF---- 235 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY-PVV 329 +S + +L + L + +R T ++ M+ + Sbjct: 236 ----------------------YMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYE 273 Query: 330 KEQSQPCADNA 340 E+ +P + Sbjct: 274 GEELKPYTEPE 284 >1KOA-A nrPDB Length = 491 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 69/337 (20%), Positives = 135/337 (40%), Gaps = 50/337 (14%) Query: 22 REYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKK 78 ++Y+ + D Y + +LG G + V K + K+ Sbjct: 35 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKET 94 Query: 79 IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDF----KQLYQILTDFDI 134 +++E++ + LR ++ L D +D +++E+++ + + +++ + Sbjct: 95 VRKEIQTMSVLRH-PTLVNLHDAFED--DNEMVMIYEFMSGGELFEKVADEHNKMSEDEA 151 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ-KKLRLIDWGLAEFYHPAQEYNVRV 193 YM ++ K L + H +H D+KP N+M ++ +L+LID+GL P Q V Sbjct: 152 VEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT 211 Query: 194 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTE 253 + F PE+ + + Y DMWS+G + ++ PF G+++ + L + Sbjct: 212 GTAEFAAPEV-AEGKPVGYYTDMWSVGVLSYILLSGLSPF-GGENDDETLRNV------- 262 Query: 254 ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR 313 K + + +S + D + KLL D R Sbjct: 263 --------------------------KSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTR 296 Query: 314 LTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR 350 +T +A+EHP+ P + P D+ + SS T R Sbjct: 297 MTIHQALEHPWLTP----GNAPGRDSQIPSSRYTKIR 329 >2QNJ-A nrPDB Length = 328 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 138/313 (44%), Gaps = 53/313 (16%) Query: 29 AHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREV 83 P GN Y+L++ +G+G +++V A +I V +KI+ P +K+ REV Sbjct: 6 DEQPHIGN---YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREV 62 Query: 84 KILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYE 140 +I++ L NI+KL + ++ KT L+ EY + D+ + + + + R + Sbjct: 63 RIMKIL-NHPNIVKLFEVIE--TEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQ 119 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 ++ A+ YCH K I+HRD+K N+++D +++ D+G + + + + S + Sbjct: 120 IVSAVQYCHQKRIVHRDLKAENLLLDA-DMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 178 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK 260 PEL + +D+WSLG +L +++ PF GQ+ + R+ + Sbjct: 179 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLR-----------G 226 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 320 KY I +S + +LL + L + +R T ++ M Sbjct: 227 KYRIPF--------------------------YMSTDCENLLKRFLVLNPIKRGTLEQIM 260 Query: 321 EHPYFYPVVKEQS 333 + + +E Sbjct: 261 KDRWINAGHEEDE 273 >3N9X-A nrPDB Length = 432 Score = 251 bits (640), Expect = 4e-67, Method: Composition-based stats. Identities = 85/384 (22%), Positives = 166/384 (43%), Gaps = 71/384 (18%) Query: 20 RSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV----- 74 RE ++ + + D+Y + +GRG Y V+ A + + V +K + + Sbjct: 9 SGRENLYFQG-IKNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLI 67 Query: 75 KKKKIKREVKILENLRGGTNIIKLIDTVKDPV---SKTPALVFEYINNTDFKQLYQ---I 128 K+I RE+ IL L+ II+L D + +V E I ++D K+L++ Sbjct: 68 DCKRILREITILNRLKS-DYIIRLYDLIIPDDLLKFDELYIVLE-IADSDLKKLFKTPIF 125 Query: 129 LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE 188 LT+ I+ +Y LL ++ H GI+HRD+KP N +++ Q +++ D+GLA + ++ Sbjct: 126 LTEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLN-QDCSVKVCDFGLARTINSEKD 184 Query: 189 Y-----------------------NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 225 V +R+++ PEL++ + Y S+D+WS GC+ A Sbjct: 185 TNIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAE 244 Query: 226 MI----------FRREPFFHG-----------------QDNYDQLVRIAKVLGTEELYGY 258 ++ R P F G + N DQL I ++GT Sbjct: 245 LLNMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDL 304 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE 318 ++ + + + +S + ++LL+ +L+++ +R+T + Sbjct: 305 KNINKPEVIKYIKLFPHRKP------INLKQKYPSISDDGINLLESMLKFNPNKRITIDQ 358 Query: 319 AMEHPYFYPVVKEQSQPCADNAVL 342 A++HPY V K++ + + ++ Sbjct: 359 ALDHPYLKDVRKKKLENFSTKKII 382 >5ZTN-A nrPDB Length = 429 Score = 250 bits (639), Expect = 5e-67, Method: Composition-based stats. Identities = 81/358 (22%), Positives = 164/358 (45%), Gaps = 40/358 (11%) Query: 3 GPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITN 62 G A R + N+ + VP Y++++ +G+G + +V +A + Sbjct: 62 GLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKV 121 Query: 63 NERVVVKILKPVKK--KKIKREVKILENLR-----GGTNIIKLIDTVKDPVSKTPALVFE 115 ++ V +K+++ K+ ++ E++ILE+LR N+I +++ + FE Sbjct: 122 HQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENF--TFRNHICMTFE 179 Query: 116 YINNTDFKQL----YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKK 171 ++ ++ + +Q + +R + + +L+ LD H I+H D+KP N+++ Q + Sbjct: 180 LLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRS 239 Query: 172 -LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRR 230 +++ID+G + + H Q + SR+++ PE+++ + Y +DMWSLGC+LA ++ Sbjct: 240 GIKVIDFGSSCYEH--QRVYTYIQSRFYRAPEVILGAR-YGMPIDMWSLGCILAELLTGY 296 Query: 231 EPFFHGQDNYDQLVRIAKVLGTEEL---------------YGYLKKYHIDLDPHFNDILG 275 P G+D DQL + ++LG GY + + + +L Sbjct: 297 -PLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLN 355 Query: 276 QHSRKRWENFIHSENRHL-------VSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 +R + E+R P LD L + L +D R+T +A+ HP+ Sbjct: 356 GGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR 413 >3GUB-A nrPDB Length = 295 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 68/315 (21%), Positives = 132/315 (41%), Gaps = 53/315 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---------VKKKKIKREVKILEN 88 D Y +LG G+++ V + + + K +K V ++ I+REV IL+ Sbjct: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKAL 145 ++ N+I L + ++ L+ E + + + LT+ + ++ ++L + Sbjct: 71 IQH-PNVITLHEVYENKTD--VILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGV 127 Query: 146 DYCHSKGIMHRDVKPHNVMI---DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 202 Y HS I H D+KP N+M+ + + ++++ID+GLA E+ + F PE Sbjct: 128 YYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPE 187 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 +V+Y+ DMWS+G + ++ PF G + L ++ V Sbjct: 188 -IVNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANVSAV------------- 232 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 E S A D + +LL D ++R+T +++++H Sbjct: 233 --------------------NYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQH 272 Query: 323 PYFYPVVKEQSQPCA 337 P+ P +Q+ A Sbjct: 273 PWIKPKDTQQALSSA 287 >3NIE-A nrPDB Length = 429 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 93/385 (24%), Positives = 167/385 (43%), Gaps = 73/385 (18%) Query: 22 REYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV-----KK 76 + A + + D+Y++ +GRG Y V+ A + N+ V +K + + Sbjct: 12 ENLYFQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDC 71 Query: 77 KKIKREVKILENLRGGTNIIKLIDTV--KDPVS-KTPALVFEYINNTDFKQLYQ---ILT 130 K+I RE+ IL L+ II+L D + +D + +V E I ++D K+L++ LT Sbjct: 72 KRILREITILNRLKS-DYIIRLHDLIIPEDLLKFDELYIVLE-IADSDLKKLFKTPIFLT 129 Query: 131 DFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-- 188 + ++ +Y LL + H GI+HRD+KP N +++ Q +++ D+GLA + ++ Sbjct: 130 EQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLN-QDCSVKICDFGLARTINSDKDIH 188 Query: 189 ------------------------YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLA 224 V +R+++ PEL++ + Y S+D+WS GC+ A Sbjct: 189 IVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFA 248 Query: 225 SMI----------FRREPFFHG-----------------QDNYDQLVRIAKVLGTEELYG 257 ++ R P F G + N DQL I V+GT Sbjct: 249 ELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEED 308 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317 + I + S+ +S E +DLL+ +LR++ Q+R+T Sbjct: 309 ------LKCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITID 362 Query: 318 EAMEHPYFYPVVKEQSQPCADNAVL 342 +A+ HPY V KE + + ++ Sbjct: 363 KALSHPYLKDVRKENLENFSTEKII 387 >3KN6-A nrPDB Length = 325 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 129/307 (42%), Gaps = 36/307 (11%) Query: 44 RKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVK 103 + LG G +S + ++ +N+ VKI+ + ++E+ L+ G NI+KL + Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFH 76 Query: 104 DPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYCHSKGIMHRDVKP 160 D + LV E +N + + + ++ + + M +L+ A+ + H G++HRD+KP Sbjct: 77 DQLHT--FLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKP 134 Query: 161 HNVMIDHQQKK--LRLIDWGLAEFYHPAQE-YNVRVASRYFKGPELLVDYQMYDYSLDMW 217 N++ + +++ID+G A P + + ++ PELL + YD S D+W Sbjct: 135 ENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL-NQNGYDESCDLW 193 Query: 218 SLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQH 277 SLG +L +M+ + PF R E+ +KK + Sbjct: 194 SLGVILYTMLSGQVPF-------QSHDRSLTCTSAVEIMKKIKKGDFSFE---------- 236 Query: 278 SRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCA 337 E VS EA DL+ LL D +RL + + + S P Sbjct: 237 ----------GEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLM 286 Query: 338 DNAVLSS 344 +L S Sbjct: 287 TPDILGS 293 >5KZ7-A nrPDB Length = 346 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 75/323 (23%), Positives = 142/323 (43%), Gaps = 58/323 (17%) Query: 29 AHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-----KKIKREV 83 P GN Y+L++ +G+G +++V A +I + V VKI+ + +K+ REV Sbjct: 27 DEQPHIGN---YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREV 83 Query: 84 KILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYE 140 +I++ L NI+KL + ++ KT LV EY + D+ + + + + R + Sbjct: 84 RIMKVL-NHPNIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQ 140 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 ++ A+ YCH K I+HRD+K N+++D +++ D+G + + + + S + Sbjct: 141 IVSAVQYCHQKFIVHRDLKAENLLLDA-DMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 199 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK 260 PEL + +D+WSLG +L +++ PF GQ+ + R+ + Sbjct: 200 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLR-----------G 247 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 320 KY I +S + +LL K L + +R T ++ M Sbjct: 248 KYRIPF--------------------------YMSTDCENLLKKFLILNPSKRGTLEQIM 281 Query: 321 EHPYF-----YPVVKEQSQPCAD 338 + + +K +P D Sbjct: 282 KDRWMNVGHEDDELKPYVEPLPD 304 >1FOT-A nrPDB Length = 318 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 133/310 (42%), Gaps = 57/310 (18%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR-----EVKILENLR 90 + D+Q++R LG G + V + N +K+LK ++K+ + +++ ++ Sbjct: 4 SLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIV 63 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDY 147 II++ T +D ++ ++ +YI + L Q + +FY E+ AL+Y Sbjct: 64 THPFIIRMWGTFQD--AQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEY 121 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 HSK I++RD+KP N+++D + +++ D+G A++ + + PE++ Sbjct: 122 LHSKDIIYRDLKPENILLD-KNGHIKITDFGFAKYVPDVTY--TLCGTPDYIAPEVV-ST 177 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 + Y+ S+D WS G ++ M+ PF+ T + Y + + Sbjct: 178 KPYNKSIDWWSFGILIYEMLAGYTPFYDSN--------------TMKTYEKILNAELRFP 223 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL-----TAKEAMEH 322 P FN + DLL +L+ D QRL ++ H Sbjct: 224 PFFN------------------------EDVKDLLSRLITRDLSQRLGNLQNGTEDVKNH 259 Query: 323 PYFYPVVKEQ 332 P+F VV E+ Sbjct: 260 PWFKEVVWEK 269 >2I6L-A nrPDB Length = 320 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 82/319 (25%), Positives = 150/319 (47%), Gaps = 31/319 (9%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIKREVKILENLRGGTNI 95 Y ++ LG G VF A++ ++RV +K + P K RE+KI+ L NI Sbjct: 12 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRL-DHDNI 70 Query: 96 IKLIDTVKDPVSK------------TPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYEL 141 +K+ + + S+ + +V EY+ TD + + L + R +MY+L Sbjct: 71 VKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYME-TDLANVLEQGPLLEEHARLFMYQL 129 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR----VASRY 197 L+ L Y HS ++HRD+KP N+ I+ + L++ D+GLA P + + +++ Sbjct: 130 LRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKW 189 Query: 198 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 ++ P LL+ Y ++DMW+ GC+ A M+ + F G +Q+ I + + ++ Sbjct: 190 YRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKT-LFAGAHELEQMQLILESIPV--VHE 246 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317 ++ + + P + K + +S EA+D L+++L + RLTA+ Sbjct: 247 EDRQELLSVIPVYIRNDMTEPHKPLTQLLPG-----ISREAVDFLEQILTFSPMDRLTAE 301 Query: 318 EAMEHPYFYPVVKEQSQPC 336 EA+ HPY +P Sbjct: 302 EALSHPYMSIYSFPMDEPI 320 >3H4J-B nrPDB Length = 336 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 122/294 (41%), Gaps = 50/294 (17%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENLRGGT 93 Y + LG G + +V A + ++V +K + K +++RE+ L+ LR Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRH-P 69 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI--LTDFDIRFYMYELLKALDYCHSK 151 +IIKL D + P +V EY F + + +T+ + R + +++ A++YCH Sbjct: 70 HIIKLYDVITTPTD--IVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRH 127 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYD 211 I+HRD+KP N+++D +++ D+GL+ S + PE++ Sbjct: 128 KIVHRDLKPENLLLD-DNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAG 186 Query: 212 YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFN 271 +D+WS G +L M+ R PF ++ +L N Sbjct: 187 PEVDVWSCGIVLYVMLVGRLPFDD-------------------------EFIPNLFKKVN 221 Query: 272 DILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 + +SP A L+ +++ D QR+T +E P+F Sbjct: 222 SCVYVMP-------------DFLSPGAQSLIRRMIVADPMQRITIQEIRRDPWF 262 >4REW-A nrPDB Length = 540 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 69/317 (21%), Positives = 123/317 (38%), Gaps = 53/317 (16%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK------KIKREVKILENLRGG 92 Y L LG G + +V + +V VKIL K + KI+RE++ L+ L Sbjct: 7 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK-LFRH 65 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCH 149 +IIKL + P +V EY++ + L + + R ++L +DYCH Sbjct: 66 PHIIKLYQVISTPSD--IFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 123 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 ++HRD+KP NV++D ++ D+GL+ + S + PE++ Sbjct: 124 RHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 182 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 +D+WS G +L +++ PF L+ + + Sbjct: 183 AGPEVDIWSSGVILYALLCGTLPFDDDH--------------VPTLFKKICDGIFYTPQY 228 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVV 329 N P + LL +L+ D +R + K+ EH +F + Sbjct: 229 LN------------------------PSVISLLKHMLQVDPMKRASIKDIREHEWFKQDL 264 Query: 330 KEQSQPCADNAVLSSGL 346 + P ++ SS + Sbjct: 265 PKYLFP--EDPSYSSTM 279 >5JZN-A nrPDB Length = 280 Score = 247 bits (630), Expect = 6e-66, Method: Composition-based stats. Identities = 71/297 (23%), Positives = 123/297 (41%), Gaps = 48/297 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGGT 93 + Y++ R +G G ++ V E + + +KI+K K + I+ EV IL ++ Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKH-P 77 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHS 150 NI+ LI+ + P LV E + D T+ D +Y L A+ Y HS Sbjct: 78 NIVLLIEEMDVPTE--LYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHS 135 Query: 151 KGIMHRDVKPHNVMI---DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 I+HRD+KP N+++ K L+L D+GLA Y V + + PE++ + Sbjct: 136 LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV-DGPLYTV-CGTPTYVAPEIIAET 193 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 Y +D+W+ G + ++ PF D+ + L + + +D Sbjct: 194 -GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVL------------FDQILMGQVDFP 240 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 + VS A +L+ +L D QR +A + +EHP+ Sbjct: 241 SPY--------------------WDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPW 277 >3EB0-A nrPDB Length = 383 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 93/347 (26%), Positives = 162/347 (46%), Gaps = 55/347 (15%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNI 95 + Y L + LG G + V E +I + +R +K + + K RE+ I++ L NI Sbjct: 5 SSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYK-NRELDIMKVL-DHVNI 62 Query: 96 IKLIDTVKDPVS------------------------------------KTPALVFEYINN 119 IKL+D K ++ EY+ + Sbjct: 63 IKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPD 122 Query: 120 T------DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLR 173 T F + + + I Y+Y+L +A+ + HS GI HRD+KP N++++ + L+ Sbjct: 123 TLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLK 182 Query: 174 LIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 L D+G A+ P++ + SR+++ PEL++ Y S+D+WS+GC+ +I + P Sbjct: 183 LCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGK-PL 241 Query: 234 FHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDI-LGQHSRKRWENFIHSENRH 292 F G+ + DQLVRI +++GT K+ I ++PH+ ++ K W + Sbjct: 242 FSGETSIDQLVRIIQIMGTPT-----KEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPS 296 Query: 293 LVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADN 339 L A+DLL+++LRY+ R+ EAM HP+F + +N Sbjct: 297 L----AIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYESEVKNN 339 >4CFF-A nrPDB Length = 571 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 68/306 (22%), Positives = 120/306 (39%), Gaps = 51/306 (16%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK------KIKREVKILENLRGG 92 Y L LG G + +V + +V VKIL K + KIKRE++ L+ L Sbjct: 34 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRH 92 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL---YQILTDFDIRFYMYELLKALDYCH 149 +IIKL + P +V EY++ + + + + + R ++L A+DYCH Sbjct: 93 PHIIKLYQVISTPTD--FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 150 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 ++HRD+KP NV++D ++ D+GL+ + S + PE++ Sbjct: 151 RHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 209 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 +D+WS G +L +++ PF L+ ++ + + Sbjct: 210 AGPEVDIWSCGVILYALLCGTLPFDDEH--------------VPTLFKKIRGGVFYIPEY 255 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVV 329 N + LL +L+ D +R T K+ EH +F + Sbjct: 256 LNRSVAT------------------------LLMHMLQVDPLKRATIKDIREHEWFKQDL 291 Query: 330 KEQSQP 335 P Sbjct: 292 PSYLFP 297 >6FDY-U nrPDB Length = 276 Score = 246 bits (629), Expect = 8e-66, Method: Composition-based stats. Identities = 77/305 (25%), Positives = 129/305 (42%), Gaps = 51/305 (16%) Query: 32 PSWGNQ--DDYQLVRKLGRGKYSEVFEAI-NITNNERVVVKI-----LKPVKKKKIKREV 83 P WG D + L +LG G Y+ V++A E V +K L + + E+ Sbjct: 3 PGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEI 62 Query: 84 KILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYE 140 +IL+ +R +I++L D D S L+ E+ D + IL + R +M + Sbjct: 63 EILKGIRH-PHIVQLKDFQWD--SDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQ 119 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDH-QQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK 199 L AL + H + I H D+KP N+++ ++ L+L D+G A+ P E +V S + Sbjct: 120 LASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYM 179 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE++ Q YD +D+WS+G +L +F + PF Sbjct: 180 APEMVCQRQ-YDARVDLWSMGVILYEALFGQPPF-------------------------- 212 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 + R I R L+S + DLL +LL D +R++ ++ Sbjct: 213 ---------ASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDF 263 Query: 320 MEHPY 324 HP+ Sbjct: 264 FAHPW 268 >1KOB-A nrPDB Length = 387 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 75/337 (22%), Positives = 139/337 (41%), Gaps = 51/337 (15%) Query: 22 REYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK---PVKKKK 78 ++Y V D Y ++ +LG G + V + V K + P+ K Sbjct: 35 KKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYT 94 Query: 79 IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDI 134 +K E+ I+ L +I L D +D L+ E+++ + +++ ++ Sbjct: 95 VKNEISIMNQL-HHPKLINLHDAFEDKYE--MVLILEFLSGGELFDRIAAEDYKMSEAEV 151 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ-KKLRLIDWGLAEFYHPAQEYNVRV 193 YM + + L + H I+H D+KP N+M + ++ +++ID+GLA +P + V Sbjct: 152 INYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTT 211 Query: 194 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTE 253 A+ F PE +VD + + DMW++G + ++ PF G+D+ + L + + Sbjct: 212 ATAEFAAPE-IVDREPVGFYTDMWAIGVLGYVLLSGLSPF-AGEDDLETLQNVKRC---- 265 Query: 254 ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR 313 WE + VSPEA D + LL+ + ++R Sbjct: 266 ---------------------------DWE--FDEDAFSSVSPEAKDFIKNLLQKEPRKR 296 Query: 314 LTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR 350 LT +A+EHP+ + + SS R Sbjct: 297 LTVHDALEHPWLKG-----DHSNLTSRIPSSRYNKIR 328 >5EZV-A nrPDB Length = 560 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 68/306 (22%), Positives = 120/306 (39%), Gaps = 51/306 (16%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK------KIKREVKILENLRGG 92 Y L LG G + +V + +V VKIL K + KIKRE++ L+ L Sbjct: 29 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRH 87 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL---YQILTDFDIRFYMYELLKALDYCH 149 +IIKL + P +V EY++ + + + + + R ++L A+DYCH Sbjct: 88 PHIIKLYQVISTPTD--FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 145 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 ++HRD+KP NV++D ++ D+GL+ + S + PE++ Sbjct: 146 RHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 204 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 +D+WS G +L +++ PF L+ ++ + + Sbjct: 205 AGPEVDIWSCGVILYALLCGTLPFDDEH--------------VPTLFKKIRGGVFYIPEY 250 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVV 329 N + LL +L+ D +R T K+ EH +F + Sbjct: 251 LNRSVAT------------------------LLMHMLQVDPLKRATIKDIREHEWFKQDL 286 Query: 330 KEQSQP 335 P Sbjct: 287 PSYLFP 292 >6CKI-A nrPDB Length = 316 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 73/322 (22%), Positives = 133/322 (41%), Gaps = 42/322 (13%) Query: 37 QDDYQLVR-KLGRGKYSEVFEAINITNNERVVVKILKPVK---KKKIKREVKILENLRGG 92 +D YQL LG G ++ V IN+ ++ VKI++ + ++ REV++L +G Sbjct: 11 EDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGH 70 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYCH 149 N+++ LVFE + + + + ++ ALD+ H Sbjct: 71 RNVLE--LIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLH 128 Query: 150 SKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYH--------PAQEYNVRVASRYFK 199 +KGI HRD+KP N++ +H + +++ D+GL E S + Sbjct: 129 NKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYM 188 Query: 200 GPELLV----DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEEL 255 PE++ + +YD D+WSLG +L ++ PF Sbjct: 189 APEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPF------------------VGRC 230 Query: 256 YGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT 315 + P ++L + ++ F ++ +S A DL+ KLL D +QRL+ Sbjct: 231 GSDCGWDRGEACPACQNMLFESIQEGKYEF-PDKDWAHISCAAKDLISKLLVRDAKQRLS 289 Query: 316 AKEAMEHPYFYPVVKEQSQPCA 337 A + ++HP+ E + P Sbjct: 290 AAQVLQHPWVQGCAPENTLPTP 311 >2X4F-A nrPDB Length = 373 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 72/335 (21%), Positives = 137/335 (40%), Gaps = 48/335 (14%) Query: 4 PAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRK--LGRGKYSEVFEAINIT 61 P R A + Y + + LG G++ +V + Sbjct: 53 PVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETA 112 Query: 62 NNERVVVKILKP---VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYIN 118 ++ KI+K K+++K E+ ++ L N+I+L D + LV EY++ Sbjct: 113 TGLKLAAKIIKTRGMKDKEEVKNEISVMNQL-DHANLIQLYDAFES--KNDIVLVMEYVD 169 Query: 119 NTDFKQLY----QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVM-IDHQQKKLR 173 + LT+ D +M ++ + + + H I+H D+KP N++ ++ K+++ Sbjct: 170 GGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIK 229 Query: 174 LIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 +ID+GLA Y P ++ V + F PE++ +Y + DMWS+G + ++ PF Sbjct: 230 IIDFGLARRYKPREKLKVNFGTPEFLAPEVV-NYDFVSFPTDMWSVGVIAYMLLSGLSPF 288 Query: 234 FHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHL 293 G ++ + L I RW+ + E Sbjct: 289 L-GDNDAETLNNILAC-------------------------------RWD--LEDEEFQD 314 Query: 294 VSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPV 328 +S EA + + KLL + R++A EA++HP+ Sbjct: 315 ISEEAKEFISKLLIKEKSWRISASEALKHPWLSDH 349 >4PDS-A nrPDB Length = 347 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 126/315 (40%), Gaps = 58/315 (18%) Query: 33 SWGNQDDYQLV-RKLGRGKYSEVFEAINITNNERVVVKILKPVKK----KKIKREVKILE 87 G D+ ++ +G+G ++ V +AI T + VKI+ K + RE+++L+ Sbjct: 25 KTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQ 84 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL---YQILTDFDIRFYMYELLKA 144 L I++L +D S +V E+++ D + + + R ++L A Sbjct: 85 KL-NHPRIVRLKGFYEDTES--YYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTA 141 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKK-LRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 + Y HS GI HRD+KP N++I+ +++ +GLA+ + + PE+ Sbjct: 142 IKYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEV 201 Query: 204 LVDYQM------------YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG 251 + Y +DMWS+GC++ ++ PF DQL Sbjct: 202 IRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF--SGSTQDQL-------- 251 Query: 252 TEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQ 311 Y + + P +S EA D +D LL+ D Sbjct: 252 ----YKQIGRGSYHEGP--------------------LKDFRISEEARDFIDSLLQVDPN 287 Query: 312 QRLTAKEAMEHPYFY 326 R TA +A+ HP+ Sbjct: 288 NRSTAAKALNHPWIK 302 >3FXW-A nrPDB Length = 336 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 72/320 (22%), Positives = 124/320 (38%), Gaps = 44/320 (13%) Query: 33 SWGNQDDYQLVR-KLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRG 91 + DDYQL + LG G +V E + ++ +K+L K ++EV G Sbjct: 23 KYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL--YDSPKARQEVDHHWQASG 80 Query: 92 GTNIIKLIDTVKD--PVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKA 144 G +I+ ++D ++ + ++ E + + Q T+ + M ++ A Sbjct: 81 GPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTA 140 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 202 + + HS I HRDVKP N++ ++K L+L D+G A+ + Y+ PE Sbjct: 141 IQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKET-TQNALQTPCYTPYYVAPE 199 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 +L + YD S DMWSLG ++ ++ PF+ + Sbjct: 200 VL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYS---------------------NTGQAI 237 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 + W VS +A L+ LL+ D +RLT + M H Sbjct: 238 SPGMKRRIRLGQYGFPNPEWSE---------VSEDAKQLIRLLLKTDPTERLTITQFMNH 288 Query: 323 PYFYPVVKEQSQPCADNAVL 342 P+ + P VL Sbjct: 289 PWINQSMVVPQTPLHTARVL 308 >2W96-B nrPDB Length = 306 Score = 246 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 77/312 (24%), Positives = 142/312 (45%), Gaps = 32/312 (10%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKILENLR--G 91 Y+ V ++G G Y V++A + + V +K ++ ++ REV +L L Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFE 64 Query: 92 GTNIIKLIDTV---KDPVSKTPALVFEYINNTDFKQLYQI-----LTDFDIRFYMYELLK 143 N+++L+D + LVFE+++ D + L I+ M + L+ Sbjct: 65 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLR 123 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 LD+ H+ I+HRD+KP N+++ ++L D+GLA Y + V + +++ PE+ Sbjct: 124 GLDFLHANCIVHRDLKPENILVTS-GGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 L+ Y +DMWS+GC+ A M FRR+P F G DQL +I ++G + + Sbjct: 183 LLQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 240 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 L + + + LL ++L ++ +R++A A++H Sbjct: 241 ----------LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHS 290 Query: 324 YFYPVVKEQSQP 335 Y K++ P Sbjct: 291 YL---HKDEGNP 299 >6FD3-A nrPDB Length = 300 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 126/298 (42%), Gaps = 46/298 (15%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV---KKKKIKREVKILENLRG 91 + Y K+G+G V+ A++I + V +K + KK+ I E+ ++ + Sbjct: 19 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKN 78 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDYCH 149 NI+ +D+ V +V EY+ + + + I E L+ALD+ H Sbjct: 79 -PNIVNYLDSYL--VGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLH 135 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNVRVASRYFKGPELLVDYQ 208 S ++HRD+K N+++ ++L D+G P Q + + V + Y+ PE++ + Sbjct: 136 SNQVIHRDIKSDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRK 193 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 Y +D+WSLG M M+ P+ + ++ L IA GT EL Sbjct: 194 AYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIA-TNGTPEL------------- 238 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 +N +S D L++ L D +R +AKE ++HP+ Sbjct: 239 --------------------QNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 276 >3IS5-A nrPDB Length = 285 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 130/307 (42%), Gaps = 54/307 (17%) Query: 35 GNQDD-YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK----KKIKREVKILENL 89 G DD + RKLG G + +V ++ V+K + + ++I+ E+++L++L Sbjct: 18 GTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSL 77 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-------QILTDFDIRFYMYELL 142 NIIK+ + +D +V E + + + L++ + M +++ Sbjct: 78 -DHPNIIKIFEVFED--YHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMM 134 Query: 143 KALDYCHSKGIMHRDVKPHNVMI--DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 AL Y HS+ ++H+D+KP N++ +++ID+GLAE + + + + Sbjct: 135 NALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMA 194 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK 260 PE+ + + D+WS G ++ ++ PF Q ++ Sbjct: 195 PEVF--KRDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQ----------QKATYKEP 242 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 320 Y ++ P ++P+A+DLL ++L D ++R +A + + Sbjct: 243 NYAVECRP-------------------------LTPQAVDLLKQMLTKDPERRPSAAQVL 277 Query: 321 EHPYFYP 327 H +F Sbjct: 278 HHEWFKQ 284 >4UZD-A nrPDB Length = 287 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 78/318 (24%), Positives = 143/318 (44%), Gaps = 54/318 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK------IKREVKILENLRG 91 +D+++ R LG+GK+ V+ A + + +K+L + +K ++REV+I +LR Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYELLKALDYC 148 NI++L D L+ EY + Q L+ FD Y+ EL AL YC Sbjct: 68 -PNILRLYGYFHDATR--VYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYC 124 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQ 208 HSK ++HRD+KP N+++ +L++ D+G + + P+ + + PE++ + + Sbjct: 125 HSKRVIHRDIKPENLLLGSA-GELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMI-EGR 181 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 M+D +D+WSLG + + + PF + RI++V T + Sbjct: 182 MHDEKVDLWSLGVLCYEFLVGKPPF-EANTYQETYKRISRVEFTFPDF------------ 228 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPV 328 V+ A DL+ +LL+++ QR +E +EHP+ Sbjct: 229 -------------------------VTEGARDLISRLLKHNPSQRPMLREVLEHPWITAN 263 Query: 329 VKEQSQPCADNAVLSSGL 346 + S C + ++ L Sbjct: 264 SSKPSN-CQNKESAAAAL 280 >3COM-A nrPDB Length = 314 Score = 243 bits (621), Expect = 7e-65, Method: Composition-based stats. Identities = 58/298 (19%), Positives = 119/298 (39%), Gaps = 46/298 (15%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-KKIKREVKILENLRGGTN 94 ++ + ++ KLG G Y V++AI+ + V +K + ++I +E+ I++ + Sbjct: 27 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQC-DSPH 85 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKALDYCHS 150 ++K + +V EY + + LT+ +I + LK L+Y H Sbjct: 86 VVKYYGSYFKNTD--LWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 143 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQM 209 +HRD+K N++++ + +L D+G+A + + N + + ++ PE++ + Sbjct: 144 MRKIHRDIKAGNILLNTE-GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI-G 201 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 Y+ D+WSLG M + P+ + + I + P Sbjct: 202 YNCVADIWSLGITAIEMAEGKPPYA----DIHPMRAIFMIPTNP-------------PPT 244 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 F L S D + + L +QR TA + ++HP+ Sbjct: 245 FR------------------KPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRS 284 >2HAK-A nrPDB Length = 328 Score = 243 bits (621), Expect = 7e-65, Method: Composition-based stats. Identities = 73/276 (26%), Positives = 130/276 (47%), Gaps = 21/276 (7%) Query: 29 AHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREV 83 P GN Y+L + +G+G +++V A ++ V VKI+ P +K+ REV Sbjct: 9 DEQPHIGN---YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREV 65 Query: 84 KILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYE 140 +I++ L NI+KL + ++ KT LV EY + D+ + + + + R + Sbjct: 66 RIMKIL-NHPNIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQ 122 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 ++ A+ YCH K I+HRD+K N+++D +++ D+G + + + + S + Sbjct: 123 IVSAVQYCHQKYIVHRDLKAENLLLDG-DMNIKIADFGFSNEFTVGNKLDTFCGSPPYAA 181 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY---- 256 PEL + +D+WSLG +L +++ PF GQ+ + R+ + Y Sbjct: 182 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLRGKYRIPFYMSTD 240 Query: 257 -GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENR 291 L K + L+P L Q + RW N H E Sbjct: 241 CENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEE 276 >4CFH-A nrPDB Length = 493 Score = 243 bits (620), Expect = 9e-65, Method: Composition-based stats. Identities = 70/317 (22%), Positives = 123/317 (38%), Gaps = 53/317 (16%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK------KIKREVKILENLRGG 92 Y L LG G + +V + +V VKIL K + KI+RE++ L+ L Sbjct: 34 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK-LFRH 92 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCH 149 +IIKL + P +V EY++ + L + + R ++L +DYCH Sbjct: 93 PHIIKLYQVISTPSD--IFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 150 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 ++HRD+KP NV++D ++ D+GL+ + S + PE++ Sbjct: 151 RHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 209 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 +D+WS G +L +++ PF L+ + + Sbjct: 210 AGPEVDIWSSGVILYALLCGTLPFDDDH--------------VPTLFKKICDGIFYTPQY 255 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVV 329 N P + LL +L+ D +R T K+ EH +F + Sbjct: 256 LN------------------------PSVISLLKHMLQVDPMKRATIKDIREHEWFKQDL 291 Query: 330 KEQSQPCADNAVLSSGL 346 + P ++ SS + Sbjct: 292 PKYLFP--EDPSYSSTM 306 >4D28-A nrPDB Length = 446 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 122/298 (40%), Gaps = 52/298 (17%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKI------LKPVKKKKIKREVKILENLRGG 92 Y++ R +G G +++V A N + V +KI LK +IKRE+ I++ +R Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH- 68 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCH 149 NI++L + + +V E++ + L + + R Y +L+ A+ +CH Sbjct: 69 PNIVRLYEVL--ASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCH 126 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY-NVRVASRYFKGPELLVDYQ 208 SKG+ HRD+KP N+++D L++ D+GL+ E N + + PE+L Sbjct: 127 SKGVYHRDLKPENLLLDT-NGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQG 185 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 + D+WS G +L ++ PF LY + D P Sbjct: 186 YDGSAADIWSCGVILFVILAGYLPFSETD--------------LPGLYRKINAAEFDCPP 231 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 F S E L+ ++L + + R+ + + P+F Sbjct: 232 WF------------------------SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFR 265 >6C9D-A nrPDB Length = 459 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 73/276 (26%), Positives = 130/276 (47%), Gaps = 21/276 (7%) Query: 29 AHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-----KPVKKKKIKREV 83 P GN Y+L + +G+G +++V A ++ V VKI+ P +K+ REV Sbjct: 15 DEQPHIGN---YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREV 71 Query: 84 KILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYE 140 +I++ L NI+KL + ++ KT LV EY + D+ + + + + R + Sbjct: 72 RIMKIL-NHPNIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQ 128 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 ++ A+ YCH K I+HRD+K N+++D +++ D+G + + + + S + Sbjct: 129 IVSAVQYCHQKYIVHRDLKAENLLLDG-DMNIKIADFGFSNEFTVGNKLDEFCGSPPYAA 187 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY---- 256 PEL + +D+WSLG +L +++ PF GQ+ + R+ + Y Sbjct: 188 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLRGKYRIPFYMSTD 246 Query: 257 -GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENR 291 L K + L+P L Q + RW N H E Sbjct: 247 CENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEE 282 >2JDO-A nrPDB Length = 342 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 73/312 (23%), Positives = 125/312 (40%), Gaps = 58/312 (18%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV------KKKKIKREVKILENL 89 +D+ ++ LG+G + +V +KIL+ + E ++L+N Sbjct: 8 TMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNT 67 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALD 146 R + L + V EY N + ++ T+ RFY E++ AL+ Sbjct: 68 RH-PFLTALKYAFQ--THDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 124 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFKGPELLV 205 Y HS+ +++RD+K N+M+D + +++ D+GL + + + PE+L Sbjct: 125 YLHSRDVVYRDIKLENLMLD-KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 183 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 D Y ++D W LG ++ M+ R PF+ N D E L+ + I Sbjct: 184 DND-YGRAVDWWGLGVVMYEMMCGRLPFY----NQDH----------ERLFELILMEEIR 228 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-----AKEAM 320 +SPEA LL LL+ D +QRL AKE M Sbjct: 229 FP------------------------RTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVM 264 Query: 321 EHPYFYPVVKEQ 332 EH +F + + Sbjct: 265 EHRFFLSINWQD 276 >6CMJ-A nrPDB Length = 321 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 72/348 (20%), Positives = 146/348 (41%), Gaps = 62/348 (17%) Query: 19 LRSREYWDYEAHVPSWGNQD-----DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP 73 + + HV G QD Y L ++G+G Y V A N +N +K+L Sbjct: 10 GSAENLYFQGHHVSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSK 69 Query: 74 VKK--------------KKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINN 119 K +++ +E+ IL+ L N++KL++ + DP +VFE +N Sbjct: 70 KKLIRQAGGCIQPRGPIEQVYQEIAILKKL-DHPNVVKLVEVLDDPNEDHLYMVFELVNQ 128 Query: 120 TDFKQL--YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDW 177 ++ + L++ RFY +L+K ++Y H + I+HRD+KP N+++ + +++ D+ Sbjct: 129 GPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHIKIADF 187 Query: 178 GLAEFYH-PAQEYNVRVASRYFKGPELLVDYQMY--DYSLDMWSLGCMLASMIFRREPFF 234 G++ + + V + F PE L + + +LD+W++G L +F + PF Sbjct: 188 GVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF- 246 Query: 235 HGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLV 294 +++ L+ +K ++ ++ + Sbjct: 247 ----------MDERIMC---LHSKIKSQALEFP----------------------DQPDI 271 Query: 295 SPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVL 342 + + DL+ ++L + + R+ E HP+ E +N L Sbjct: 272 AEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTL 319 >4RED-A nrPDB Length = 351 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 68/317 (21%), Positives = 122/317 (38%), Gaps = 53/317 (16%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK------KIKREVKILENLRGG 92 Y L LG G + +V + V VKIL K + KI+RE++ L+ L Sbjct: 15 HYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLK-LFRH 73 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCH 149 +IIKL + P +V EY++ + L + + R ++L +DYCH Sbjct: 74 PHIIKLYQVISTPSD--IFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH 131 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 ++HRD+KP NV++D ++ D+GL+ + S + PE++ Sbjct: 132 RHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 +D+WS G +L +++ PF L+ + + Sbjct: 191 AGPEVDIWSSGVILYALLCGTLPFDDDH--------------VPTLFKKICDGIFYTPQY 236 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVV 329 N P + LL +L+ D +R + K+ EH +F + Sbjct: 237 LN------------------------PSVISLLKHMLQVDPMKRASIKDIREHEWFKQDL 272 Query: 330 KEQSQPCADNAVLSSGL 346 + P ++ S+ + Sbjct: 273 PKYLFP--EDPSYSTTM 287 >3D2K-A nrPDB Length = 272 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 134/298 (44%), Gaps = 53/298 (17%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK------IKREVKILENLRG 91 +D+ + R LG+GK+ V+ A + + +K+L + +K ++REV+I +LR Sbjct: 12 EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRH 71 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILT---DFDIRFYMYELLKALDYC 148 NI++L D L+ EY + Q L+ + Y+ EL AL YC Sbjct: 72 -PNILRLYGYFHDATR--VYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYC 128 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQ 208 HSK ++HRD+KP N+++ +L++ D+G + + P+ + + PE++ + + Sbjct: 129 HSKRVIHRDIKPENLLLGS-NGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMI-EGR 185 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 M+D +D+WSLG + + PF + RI++V T + Sbjct: 186 MHDEKVDLWSLGVLCYEFLVGMPPF-EAHTYQETYRRISRVEFTFPDF------------ 232 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 V+ A DL+ +LL+++ QRLT E +EHP+ Sbjct: 233 -------------------------VTEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >4D2V-A nrPDB Length = 356 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 74/310 (23%), Positives = 138/310 (44%), Gaps = 56/310 (18%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKP----VKKKKIKREVKILENLRGGTNI 95 Y+L +G G +++V A +I E V +KI+ +IK E++ L+NLR +I Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQ-HI 89 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKG 152 +L ++ + +V EY + L++ + R +++ A+ Y HS+G Sbjct: 90 CQLYHVLE--TANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQG 147 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN--VRVASRYFKGPELLVDYQMY 210 HRD+KP N++ D + KL+LID+GL ++Y+ + + PEL+ Sbjct: 148 YAHRDLKPENLLFD-EYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYL 206 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 D+WS+G +L ++ PF D+ +AK++ Sbjct: 207 GSEADVWSMGILLYVLMCGFLPF----DDDTAAALVAKIM-------------------- 242 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF----- 325 G++ +W +SP ++ LL ++L+ D ++R++ K + HP+ Sbjct: 243 ---RGKYDVPKW-----------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYN 288 Query: 326 YPVVKEQSQP 335 YPV + P Sbjct: 289 YPVEWQSKNP 298 >5KCV-A nrPDB Length = 460 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 72/312 (23%), Positives = 126/312 (40%), Gaps = 59/312 (18%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV------KKKKIKREVKILENL 89 ++++ ++ LG+G + +V +KILK + E ++L+N Sbjct: 160 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 219 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALD 146 R + L + + V EY N + ++ ++ RFY E++ ALD Sbjct: 220 RH-PFLTALKYSFQ--THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 276 Query: 147 YCHS-KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFKGPELL 204 Y HS K +++RD+K N+M+D + +++ D+GL + + + PE+L Sbjct: 277 YLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 335 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 D Y ++D W LG ++ M+ R PF+ N D +L E + Sbjct: 336 EDND-YGRAVDWWGLGVVMYEMMCGRLPFY----NQDHEKLFELILMEEIRFP------- 383 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-----AKEA 319 + PEA LL LL+ D +QRL AKE Sbjct: 384 ---------------------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEI 416 Query: 320 MEHPYFYPVVKE 331 M+H +F +V + Sbjct: 417 MQHRFFAGIVWQ 428 >2YZA-A nrPDB Length = 276 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 68/306 (22%), Positives = 120/306 (39%), Gaps = 51/306 (16%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK------KIKREVKILENLRGG 92 Y L LG G + +V + +V VKIL K + KIKRE++ L+ L Sbjct: 12 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRH 70 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL---YQILTDFDIRFYMYELLKALDYCH 149 +IIKL + P +V EY++ + + + + + R ++L A+DYCH Sbjct: 71 PHIIKLYQVISTPTD--FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 128 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 ++HRD+KP NV++D ++ D+GL+ + S + PE++ Sbjct: 129 RHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLY 187 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 +D+WS G +L +++ PF L+ ++ + + Sbjct: 188 AGPEVDIWSCGVILYALLCGTLPFDDEH--------------VPTLFKKIRGGVFYIPEY 233 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVV 329 N + LL +L+ D +R T K+ EH +F + Sbjct: 234 LNRSVAT------------------------LLMHMLQVDPLKRATIKDIREHEWFKQDL 269 Query: 330 KEQSQP 335 P Sbjct: 270 PSYLFP 275 >3MV5-A nrPDB Length = 342 Score = 240 bits (613), Expect = 6e-64, Method: Composition-based stats. Identities = 72/312 (23%), Positives = 126/312 (40%), Gaps = 59/312 (18%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV------KKKKIKREVKILENL 89 ++++ ++ LG+G + +V +KILK + E ++L+N Sbjct: 8 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 67 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALD 146 R + L + + V EY N + ++ ++ RFY E++ ALD Sbjct: 68 RH-PFLTALKYSFQ--THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 124 Query: 147 YCHS-KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFKGPELL 204 Y HS K +++RD+K N+M+D + +++ D+GL + + + PE+L Sbjct: 125 YLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 183 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 D Y ++D W LG ++ M+ R PF+ N D +L E + Sbjct: 184 EDND-YGRAVDWWGLGVVMYEMMCGRLPFY----NQDHEKLFELILMEEIRFP------- 231 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-----AKEA 319 + PEA LL LL+ D +QRL AKE Sbjct: 232 ---------------------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEI 264 Query: 320 MEHPYFYPVVKE 331 M+H +F +V + Sbjct: 265 MQHRFFAGIVWQ 276 >4FIE-A nrPDB Length = 423 Score = 240 bits (612), Expect = 7e-64, Method: Composition-based stats. Identities = 74/338 (21%), Positives = 137/338 (40%), Gaps = 50/338 (14%) Query: 2 PGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINIT 61 PGP + R R+ + P D++ K+G G V A + Sbjct: 119 PGPRSPQREPQRVSHEQFRAALQLVVDPGDPR-SYLDNFI---KIGEGSTGIVCIATVRS 174 Query: 62 NNERVVVKIL---KPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYIN 118 + + V VK + K +++ + EV I+ + + N++++ ++ V +V E++ Sbjct: 175 SGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH-ENVVEMYNSYL--VGDELWVVMEFLE 231 Query: 119 NTDFKQL--YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLID 176 + + + + I +L+AL H++G++HRD+K ++++ H +++L D Sbjct: 232 GGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTH-DGRVKLSD 290 Query: 177 WGL-AEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFH 235 +G A+ V + Y+ PEL+ Y +D+WSLG M+ M+ P+F+ Sbjct: 291 FGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PYGPEVDIWSLGIMVIEMVDGEPPYFN 349 Query: 236 GQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS 295 E +K +L P ++ H VS Sbjct: 350 -----------------EPPLKAMKMIRDNLPPRLKNL------------------HKVS 374 Query: 296 PEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQS 333 P LD+LL D QR TA E ++HP+ S Sbjct: 375 PSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 412 >4CQG-A nrPDB Length = 331 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 70/310 (22%), Positives = 137/310 (44%), Gaps = 56/310 (18%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKP----VKKKKIKREVKILENLRGGTNI 95 Y+L +G G +++V A ++ E V +KI+ ++K E+ L++LR +I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQ-HI 69 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSKG 152 +L ++ +V EY + L++ + R ++L A+ Y HS+G Sbjct: 70 CQLYHVLE--TKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQG 127 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR--VASRYFKGPELLVDYQMY 210 HRD+KP N++ D + KL+LID+GL ++Y+++ S + PEL+ Sbjct: 128 YAHRDLKPENLLFD-ENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYL 186 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 D+WS+G +L ++ PF D+ + + K++ Sbjct: 187 GSEADVWSMGILLYVLMCGFLPF----DDDNVMALYKKIM-------------------- 222 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY---- 326 G++ +W +SP ++ LL ++L+ D ++R++ + + HP+ Sbjct: 223 ---RGKYEVPKW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYS 268 Query: 327 -PVVKEQSQP 335 PV + P Sbjct: 269 CPVEWQSKTP 278 >4KS7-A nrPDB Length = 292 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 127/294 (43%), Gaps = 46/294 (15%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIKREVKILENLRGGTNIIKLIDT 101 K+G G V A + +V VK++ K +++ + EV I+ + + N++++ + Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHF-NVVEMYKS 88 Query: 102 VKDPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDYCHSKGIMHRDVK 159 V + ++ E++ + L + I +L+AL Y H++G++HRD+K Sbjct: 89 YL--VGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIK 146 Query: 160 PHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 218 ++++ +++L D+G A+ + V + Y+ PE++ +Y +D+WS Sbjct: 147 SDSILLTL-DGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLYATEVDIWS 204 Query: 219 LGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHS 278 LG M+ M+ P+F ++ +K+ P Sbjct: 205 LGIMVIEMVDGEPPYF-----------------SDSPVQAMKRLRDSPPPKLK------- 240 Query: 279 RKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ 332 N H VSP D L+++L D Q+R TA+E ++HP+ + Sbjct: 241 -----------NSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPE 283 >4JDH-A nrPDB Length = 346 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 74/338 (21%), Positives = 137/338 (40%), Gaps = 50/338 (14%) Query: 2 PGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINIT 61 PGP + R R+ + P D++ K+G G V A + Sbjct: 42 PGPRSPQREPQRVSHEQFRAALQLVVDPGDPR-SYLDNFI---KIGEGSTGIVCIATVRS 97 Query: 62 NNERVVVKIL---KPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYIN 118 + + V VK + K +++ + EV I+ + + N++++ ++ V +V E++ Sbjct: 98 SGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH-ENVVEMYNSYL--VGDELWVVMEFLE 154 Query: 119 NTDFKQL--YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLID 176 + + + + I +L+AL H++G++HRD+K ++++ H +++L D Sbjct: 155 GGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTH-DGRVKLSD 213 Query: 177 WGL-AEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFH 235 +G A+ V + Y+ PEL+ Y +D+WSLG M+ M+ P+F+ Sbjct: 214 FGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PYGPEVDIWSLGIMVIEMVDGEPPYFN 272 Query: 236 GQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS 295 E +K +L P ++ H VS Sbjct: 273 -----------------EPPLKAMKMIRDNLPPRLKNL------------------HKVS 297 Query: 296 PEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQS 333 P LD+LL D QR TA E ++HP+ S Sbjct: 298 PSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 335 >5F9E-A nrPDB Length = 353 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 129/308 (41%), Gaps = 53/308 (17%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV------KKKKIKREVKILENLRG 91 +D++L + LG+G + +VF A N+ +K LK + E ++L Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWE 78 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIR---FYMYELLKALDYC 148 + + T + + V EY+N D Q FD+ FY E++ L + Sbjct: 79 HPFLTHMFCTFQ--TKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFL 136 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNVRVASRYFKGPELLVDY 207 HSKGI++RD+K N+++D + +++ D+G+ + + N + + PE+L+ Sbjct: 137 HSKGIVYRDLKLDNILLD-KDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLG- 194 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 Q Y++S+D WS G +L M+ + PF HGQD + I Sbjct: 195 QKYNHSVDWWSFGVLLYEMLIGQSPF-HGQDEEELFHSI--------------------- 232 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK-EAMEHPYFY 326 + + EA DLL KL + ++RL + + +HP F Sbjct: 233 ----------------RMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFR 276 Query: 327 PVVKEQSQ 334 + E+ + Sbjct: 277 EINWEELE 284 >4CZT-A nrPDB Length = 464 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 127/312 (40%), Gaps = 54/312 (17%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK------KKIKREVKILENLRGG 92 Y+L R LG G +++V A N+ N + V +K++ K +IKRE+ ++ ++ Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH- 70 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCH 149 N+I++ + + V E++ + L + + R Y +L+ A+DYCH Sbjct: 71 PNVIRMFEVMASKTK--IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCH 128 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA---EFYHPAQEYNVRVASRYFKGPELLVD 206 S+G+ HRD+KP N+++D L++ D+GL+ + + + + PE++ + Sbjct: 129 SRGVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINN 187 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 D+WS G +L ++ PF LY + K Sbjct: 188 KGYDGAKADLWSCGVILFVLMAGYLPFEDSN--------------LTSLYKKIFKAEFTC 233 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 P F S A L+ ++L + R+T E +E+ +F Sbjct: 234 PPWF------------------------SASAKKLIKRILDPNPATRITFAEVIENEWFK 269 Query: 327 PVVKEQSQPCAD 338 K AD Sbjct: 270 KGYKAPKFENAD 281 >4JXF-A nrPDB Length = 266 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 132/299 (44%), Gaps = 54/299 (18%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENLRG 91 +D+++ LG+G ++ V+ A +I V +K++ K ++++ EVKI L+ Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTD----FKQLYQILTDFDIRFYMYELLKALDY 147 +I++L + +D S LV E +N + K + ++ + R +M++++ + Y Sbjct: 67 -PSILELYNYFED--SNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLY 123 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELLVD 206 HS GI+HRD+ N+++ + +++ D+GLA P +++ + + PE + Sbjct: 124 LHSHGILHRDLTLSNLLLT-RNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-IAT 181 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 + D+WSLGCM +++ R PF + L ++ Sbjct: 182 RSAHGLESDVWSLGCMFYTLLIGRPPF-DTDTVKNTLNKVV------------------- 221 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 E +S EA DL+ +LLR + RL+ ++HP+ Sbjct: 222 ------------------LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFM 262 >2F57-A nrPDB Length = 317 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 63/288 (21%), Positives = 119/288 (41%), Gaps = 46/288 (15%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIKREVKILENLRGGTNIIKLIDT 101 K+G G V A ++V VK + K +++ + EV I+ + N++ + + Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDY-HHDNVVDMYSS 110 Query: 102 VKDPVSKTPALVFEYINNTDFKQL--YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVK 159 V +V E++ + + + + I +L+AL Y H++G++HRD+K Sbjct: 111 YL--VGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIK 168 Query: 160 PHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 218 ++++ +++L D+G A+ + V + Y+ PE++ Y +D+WS Sbjct: 169 SDSILLTS-DGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRL-PYGTEVDIWS 226 Query: 219 LGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHS 278 LG M+ MI P+F+ E +++ L P D+ Sbjct: 227 LGIMVIEMIDGEPPYFN-----------------EPPLQAMRRIRDSLPPRVKDL----- 264 Query: 279 RKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 H VS LD +L + QR TA+E + HP+ Sbjct: 265 -------------HKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLK 299 >4L42-A nrPDB Length = 346 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 77/312 (24%), Positives = 136/312 (43%), Gaps = 62/312 (19%) Query: 40 YQLVRKLGRGKYSEVFEAINI---TNNERVVVKILKPV-------KKKKIKREVKILENL 89 ++L+R LG+G Y +VF+ + + +K+LK K E ILE + Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 79 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDF---KQLYQILTDFDIRFYMYELLKALD 146 + I+ LI + L+ EY++ + + I + FY+ E+ AL Sbjct: 80 KH-PFIVDLIYAFQ--TGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALG 136 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFKGPELLV 205 + H KGI++RD+KP N+M++H Q ++L D+GL + H + + + PE+L+ Sbjct: 137 HLHQKGIIYRDLKPENIMLNH-QGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 195 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 ++ ++D WSLG ++ M+ PF G++ + +I K ++ Sbjct: 196 -RSGHNRAVDWWSLGALMYDMLTGAPPF-TGENRKKTIDKILKC-------------KLN 240 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-----AKEAM 320 L P+ ++ EA DLL KLL+ + RL A E Sbjct: 241 LPPY------------------------LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQ 276 Query: 321 EHPYFYPVVKEQ 332 HP+F + E+ Sbjct: 277 AHPFFRHINWEE 288 >3DB8-A nrPDB Length = 317 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 66/347 (19%), Positives = 138/347 (39%), Gaps = 54/347 (15%) Query: 1 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 60 M A A+ A V+ + + + Y R LG+G +++ +E ++ Sbjct: 6 MSAAIAKPSAKPSAHVDPKSA-PLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDM 64 Query: 61 TNNERVVVKI------LKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVF 114 E K+ LKP +K+K+ E+ I ++L +++ +D +V Sbjct: 65 DTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDN-PHVVGFHGFFED--DDFVYVVL 121 Query: 115 EYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKK 171 E +L++ +T+ + R++M + ++ + Y H+ ++HRD+K N+ ++ Sbjct: 122 EICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLN-DDMD 180 Query: 172 LRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRR 230 +++ D+GLA + + + PE+L + + + +D+WSLGC+L +++ + Sbjct: 181 VKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCK-KGHSFEVDIWSLGCILYTLLVGK 239 Query: 231 EPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSEN 290 PF + +E Y +KK + H N Sbjct: 240 PPF--------------ETSCLKETYIRIKKNEYSVPRHIN------------------- 266 Query: 291 RHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCA 337 P A L+ ++L D R + E + +F P + Sbjct: 267 -----PVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPMRLPTS 308 >4LG4-A nrPDB Length = 299 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 60/321 (18%), Positives = 127/321 (39%), Gaps = 51/321 (15%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-PVKKKKIKREVKILENLRGGTN 94 ++ + ++ KLG G Y VF+AI+ + + V +K + ++I +E+ I++ Sbjct: 9 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQC-DSPY 67 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKALDYCHS 150 ++K + +V EY + + L + +I + LK L+Y H Sbjct: 68 VVKYYGSYFKNTD--LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 125 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQM 209 +HR++K N++++ + +L D+G+A + + N + + ++ PE++ + Sbjct: 126 MRKIHRNIKAGNILLNTE-GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG- 183 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 Y+ D+WSLG M + P+ + + I + P Sbjct: 184 YNCVADIWSLGITSIEMAEGKPPYA----DIHPMRAIFMIPTNP-------------PPT 226 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVV 329 F L S + D + K L + +QR TA + ++HP+ Sbjct: 227 FR------------------KPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK--- 265 Query: 330 KEQSQPCADNAVLSSGLTAAR 350 ++P + L + + Sbjct: 266 --NAKPVSILRDLITEAMEIK 284 >2UV2-A nrPDB Length = 325 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 73/322 (22%), Positives = 136/322 (42%), Gaps = 55/322 (17%) Query: 30 HVPSWGNQDDY-QLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR---EVKI 85 HV N +D+ +++ +LG G + +V++A N + K++ +++++ E+ I Sbjct: 28 HVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDI 87 Query: 86 LENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD----FKQLYQILTDFDIRFYMYEL 141 L + NI+KL+D ++ E+ +L + LT+ I+ + Sbjct: 88 LASC-DHPNIVKLLDAFY--YENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQT 144 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKG 200 L AL+Y H I+HRD+K N++ ++L D+G+ A+ Q + + + Y+ Sbjct: 145 LDALNYLHDNKIIHRDLKAGNILFTL-DGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMA 203 Query: 201 PELLV----DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY 256 PE+++ + YDY D+WSLG L M EP H + L++IAK Sbjct: 204 PEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IEPPHHELNPMRVLLKIAK-------- 254 Query: 257 GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA 316 ++ RW S D L K L + R T Sbjct: 255 --------------SEPPTLAQPSRW------------SSNFKDFLKKCLEKNVDARWTT 288 Query: 317 KEAMEHPYFYPVVKEQSQPCAD 338 + ++HP+ V + ++P + Sbjct: 289 SQLLQHPF---VTVDSNKPIRE 307 >4RLP-A nrPDB Length = 288 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 77/312 (24%), Positives = 136/312 (43%), Gaps = 62/312 (19%) Query: 40 YQLVRKLGRGKYSEVFEAINI---TNNERVVVKILKPV-------KKKKIKREVKILENL 89 ++L+R LG+G Y +VF+ + + +K+LK K E ILE + Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 66 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDF---KQLYQILTDFDIRFYMYELLKALD 146 + I+ LI + L+ EY++ + + I + FY+ E+ AL Sbjct: 67 KH-PFIVDLIYAFQ--TGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALG 123 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFKGPELLV 205 + H KGI++RD+KP N+M++H Q ++L D+GL + H + + + PE+L+ Sbjct: 124 HLHQKGIIYRDLKPENIMLNH-QGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 182 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 ++ ++D WSLG ++ M+ PF G++ + +I K ++ Sbjct: 183 -RSGHNRAVDWWSLGALMYDMLTGAPPF-TGENRKKTIDKILKC-------------KLN 227 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-----AKEAM 320 L P+ ++ EA DLL KLL+ + RL A E Sbjct: 228 LPPY------------------------LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQ 263 Query: 321 EHPYFYPVVKEQ 332 HP+F + E+ Sbjct: 264 AHPFFRHINWEE 275 >2Q0N-A nrPDB Length = 301 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 125/295 (42%), Gaps = 46/295 (15%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIKREVKILENLRGGTNIIKLIDT 101 K+G G V A ++ + V VK + K +++ + EV I+ + + N++++ ++ Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH-ENVVEMYNS 94 Query: 102 VKDPVSKTPALVFEYINNTDFKQL--YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVK 159 V +V E++ + + + + I +L+AL H++G++HRD+K Sbjct: 95 YL--VGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 152 Query: 160 PHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 218 ++++ H +++L D+G A+ V + Y+ PEL+ Y +D+WS Sbjct: 153 SDSILLTH-DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PYGPEVDIWS 210 Query: 219 LGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHS 278 LG M+ M+ P+F+ E +K +L P ++ Sbjct: 211 LGIMVIEMVDGEPPYFN-----------------EPPLKAMKMIRDNLPPRLKNL----- 248 Query: 279 RKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQS 333 H VSP LD+LL D QR TA E ++HP+ S Sbjct: 249 -------------HKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 290 >4XBR-A nrPDB Length = 366 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 125/295 (42%), Gaps = 46/295 (15%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIKREVKILENLRGGTNIIKLIDT 101 K+G G V A ++ + V VK + K +++ + EV I+ + + N++++ ++ Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH-ENVVEMYNS 159 Query: 102 VKDPVSKTPALVFEYINNTDFKQL--YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVK 159 V +V E++ + + + + I +L+AL H++G++HRD+K Sbjct: 160 YL--VGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 217 Query: 160 PHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 218 ++++ H +++L D+G A+ V + Y+ PEL+ Y +D+WS Sbjct: 218 SDSILLTH-DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL-PYGPEVDIWS 275 Query: 219 LGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHS 278 LG M+ M+ P+F+ E +K +L P ++ Sbjct: 276 LGIMVIEMVDGEPPYFN-----------------EPPLKAMKMIRDNLPPRLKNL----- 313 Query: 279 RKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQS 333 H VSP LD+LL D QR TA E ++HP+ S Sbjct: 314 -------------HKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 355 >3HDN-A nrPDB Length = 373 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 73/312 (23%), Positives = 124/312 (39%), Gaps = 56/312 (17%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVK------ILKPVKKKKIKREVKILEN 88 D+ ++ +G+G + +V A + VK ILK ++K I E +L Sbjct: 35 AKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLK 94 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKAL 145 ++ L + + + V +YIN + Q + RFY E+ AL Sbjct: 95 NVKHPFLVGLHFSFQ--TADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASAL 152 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFKGPELL 204 Y HS I++RD+KP N+++D Q + L D+GL + + + + PE+L Sbjct: 153 GYLHSLNIVYRDLKPENILLDS-QGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 211 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 Q YD ++D W LG +L M++ PF+ T E+Y + + Sbjct: 212 -HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRN--------------TAEMYDNILNKPL 256 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK----EAM 320 L P+ ++ A LL+ LL+ D +RL AK E Sbjct: 257 QLKPN------------------------ITNSARHLLEGLLQKDRTKRLGAKDDFMEIK 292 Query: 321 EHPYFYPVVKEQ 332 H +F + + Sbjct: 293 SHVFFSLINWDD 304 >6AO5-A nrPDB Length = 362 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 60/321 (18%), Positives = 127/321 (39%), Gaps = 51/321 (15%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-PVKKKKIKREVKILENLRGGTN 94 ++ + ++ KLG G Y VF+AI+ + + V +K + ++I +E+ I++ Sbjct: 8 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQC-DSPY 66 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKALDYCHS 150 ++K + +V EY + + L + +I + LK L+Y H Sbjct: 67 VVKYYGSYFKNTD--LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 124 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQM 209 +HR++K N++++ + +L D+G+A + + N + + ++ PE++ + Sbjct: 125 MRKIHRNIKAGNILLNTE-GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG- 182 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 Y+ D+WSLG M + P+ + + I + P Sbjct: 183 YNCVADIWSLGITSIEMAEGKPPYA----DIHPMRAIFMIPTNP-------------PPT 225 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVV 329 F L S + D + K L + +QR TA + ++HP+ Sbjct: 226 FR------------------KPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK--- 264 Query: 330 KEQSQPCADNAVLSSGLTAAR 350 ++P + L + + Sbjct: 265 --NAKPVSILRDLITEAMEIK 283 >5LOH-A nrPDB Length = 341 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 73/348 (20%), Positives = 127/348 (36%), Gaps = 58/348 (16%) Query: 3 GPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITN 62 GP A E + E VP + +++ +V+ + RG + +V+ Sbjct: 1 GPHMDPTAGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQK--G 58 Query: 63 NERVVVKILKPVK------KKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEY 116 + VK++K +++ E L L I+ L +++ + LV EY Sbjct: 59 GKLYAVKVVKKADMINKNMTHQVQAERDALA-LSKSPFIVHLYYSLQS--ANNVYLVMEY 115 Query: 117 INNTD---FKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLR 173 + D +Y + Y+ E+ ALDY H GI+HRD+KP N++I ++ ++ Sbjct: 116 LIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNE-GHIK 174 Query: 174 LIDWGLAEF-------YHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASM 226 L D+GL++ + + PELL+ + + ++D W+LG L Sbjct: 175 LTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLG-RAHGPAVDWWALGVCLFEF 233 Query: 227 IFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFI 286 + PF + + I K + Sbjct: 234 LTGIPPF-NDETPQQVFQNILK----------------------------------RDIP 258 Query: 287 HSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQ 334 E +S A ++ LL D +R KE HP F V E Q Sbjct: 259 WPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQ 306 >5D7A-A nrPDB Length = 308 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 61/310 (19%), Positives = 127/310 (40%), Gaps = 53/310 (17%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV--KKKKIKREVKILENLRGGTNIIK 97 ++LV +G G Y +V++ ++ + +K++ ++++IK+E+ +L+ NI Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 78 Query: 98 LIDTV--KDP--VSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKALDYC 148 K+P + LV E+ L + L + I + E+L+ L + Sbjct: 79 YYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHL 138 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELLVDY 207 H ++HRD+K NV++ + +++L+D+G+ A+ N + + Y+ PE++ Sbjct: 139 HQHKVIHRDIKGQNVLLT-ENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD 197 Query: 208 Q----MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 + YD+ D+WSLG M P +++ + Sbjct: 198 ENPDATYDFKSDLWSLGITAIEMAEGAPPLC-------------------DMHPMRALFL 238 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 I +P + K+W S + ++ L +H QR ++ M+HP Sbjct: 239 IPRNP-----APRLKSKKW------------SKKFQSFIESCLVKNHSQRPATEQLMKHP 281 Query: 324 YFYPVVKEQS 333 + E+ Sbjct: 282 FIRDQPNERQ 291 >3TXO-A nrPDB Length = 353 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 64/311 (20%), Positives = 117/311 (37%), Gaps = 58/311 (18%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV------KKKKIKREVKILENLRG 91 D+++ +R LG+G + +V A + VK+LK + E +IL R Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYC 148 + +L + P V E++N D Q + RFY E++ AL + Sbjct: 83 HPFLTQLFCCFQTP--DRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFL 140 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFKGPELLVDY 207 H KGI++RD+K NV++DH+ +L D+G+ + + + PE+L + Sbjct: 141 HDKGIIYRDLKLDNVLLDHE-GHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEM 199 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 +Y ++D W++G +L M+ PF ++ D I Sbjct: 200 -LYGPAVDWWAMGVLLYEMLCGHAPF-EAENEDDLFEAILN------------------- 238 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA------KEAME 321 + W + +A +L + + RL + + Sbjct: 239 -------DEVVYPTW-----------LHEDATGILKSFMTKNPTMRLGSLTQGGEHAILR 280 Query: 322 HPYFYPVVKEQ 332 HP+F + Q Sbjct: 281 HPFFKEIDWAQ 291 >1VZO-A nrPDB Length = 355 Score = 234 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 64/316 (20%), Positives = 132/316 (41%), Gaps = 58/316 (18%) Query: 38 DDYQLVRKLGRGKYSEVFEAINI---TNNERVVVKILKPVK-------KKKIKREVKILE 87 ++++L++ LG G Y +VF I + +K+LK + + E ++LE Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKA 144 ++R ++ L + L+ +YIN + + T+ +++ Y+ E++ A Sbjct: 114 HIRQSPFLVTLHYAFQ--TETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLA 171 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY--HPAQEYNVRVASRYFKGPE 202 L++ H GI++RD+K N+++D + L D+GL++ + + + + P+ Sbjct: 172 LEHLHKLGIIYRDIKLENILLDS-NGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPD 230 Query: 203 LLVDY-QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 ++ +D ++D WSLG ++ ++ PF + Q ++L +E Y Sbjct: 231 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQ--- 287 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-----A 316 +S A DL+ +LL D ++RL A Sbjct: 288 -------------------------------EMSALAKDLIQRLLMKDPKKRLGCGPRDA 316 Query: 317 KEAMEHPYFYPVVKEQ 332 E EH +F + + Sbjct: 317 DEIKEHLFFQKINWDD 332 >3DAK-A nrPDB Length = 290 Score = 234 bits (596), Expect = 7e-62, Method: Composition-based stats. Identities = 56/312 (17%), Positives = 117/312 (37%), Gaps = 53/312 (16%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRG 91 N+DDY+L +G G + V A E+V +K + K + ++ +E++ + Sbjct: 8 NRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQC-H 66 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----------ILTDFDIRFYMYE 140 NI+ + V LV + ++ + + +L + I + E Sbjct: 67 HPNIVSYYTSF--VVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 124 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN------VRVA 194 +L+ L+Y H G +HRDVK N+++ + +++ D+G++ F + V Sbjct: 125 VLEGLEYLHKNGQIHRDVKAGNILLG-EDGSVQIADFGVSAFLATGGDITRNKVRKTFVG 183 Query: 195 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE 254 + + PE++ + YD+ D+WS G + P+ Sbjct: 184 TPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYH----------------KYPP 227 Query: 255 LYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL 314 + + D + + K++ ++ L+ D ++R Sbjct: 228 MKVLMLTLQNDPPSLETGVQDKEMLKKYGK------------SFRKMISLCLQKDPEKRP 275 Query: 315 TAKEAMEHPYFY 326 TA E + H +F Sbjct: 276 TAAELLRHKFFQ 287 >5YV8-A nrPDB Length = 298 Score = 233 bits (595), Expect = 8e-62, Method: Composition-based stats. Identities = 64/321 (19%), Positives = 136/321 (42%), Gaps = 72/321 (22%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--------------------- 76 + Y L ++G+G Y V A N +N +K+L K Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 77 --------KKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL--Y 126 +++ +E+ IL+ L N++KL++ + DP +VFE +N ++ Sbjct: 73 CIQPRGPIEQVYQEIAILKKL-DHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTL 131 Query: 127 QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-P 185 + L++ RFY +L+K ++Y H + I+HRD+KP N+++ + +++ D+G++ + Sbjct: 132 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHIKIADFGVSNEFKGS 190 Query: 186 AQEYNVRVASRYFKGPELLVDYQMY--DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQL 243 + V + F PE L + + +LD+W++G L +F + PF Sbjct: 191 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF---------- 240 Query: 244 VRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLD 303 +++ L+ +K ++ ++ ++ + DL+ Sbjct: 241 -MDERIMC---LHSKIKSQALEFP----------------------DQPDIAEDLKDLIT 274 Query: 304 KLLRYDHQQRLTAKEAMEHPY 324 ++L + + R+ E HP+ Sbjct: 275 RMLDKNPESRIVVPEIKLHPW 295 >4B6L-A nrPDB Length = 281 Score = 233 bits (595), Expect = 9e-62, Method: Composition-based stats. Identities = 67/309 (21%), Positives = 129/309 (41%), Gaps = 53/309 (17%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENLRGGT 93 Y R LG+G ++ +EA + VK++ KP +++KI E+++ +L+ Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQH-R 69 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHS 150 +I++ +D + + E + ++ L + ++R+Y+ ++L L Y H Sbjct: 70 HIVRFSHHFED--ADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQ 127 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 +GI+HRD+K N I + +L++ D+GL A P Q + + PE+L+ Q Sbjct: 128 RGILHRDLKLGNFFIT-ENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQG 185 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 + D+WSLGC++ +++ PF + +E Y +K+ H L Sbjct: 186 HGPEADVWSLGCVMYTLLCGSPPF--------------ETADLKETYRCIKQVHYTLP-- 229 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVV 329 +S A LL +LR + R + + + H +F Sbjct: 230 ----------------------ASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGY 267 Query: 330 KEQSQPCAD 338 P + Sbjct: 268 TPDRLPISS 276 >3Q53-A nrPDB Length = 306 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 126/298 (42%), Gaps = 46/298 (15%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV---KKKKIKREVKILENLRG 91 + Y K+G+G V+ A+++ + V ++ + KK+ I E+ ++ + Sbjct: 18 DPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKN 77 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDYCH 149 NI+ +D+ V +V EY+ + + + I E L+AL++ H Sbjct: 78 -PNIVNYLDSYL--VGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLH 134 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNVRVASRYFKGPELLVDYQ 208 S ++HRD+K N+++ ++L D+G P Q + + V + Y+ PE++ + Sbjct: 135 SNQVIHRDIKSDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRK 192 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 Y +D+WSLG M MI P+ + ++ L IA GT EL Sbjct: 193 AYGPKVDIWSLGIMAIEMIEGEPPYLN-ENPLRALYLIA-TNGTPEL------------- 237 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 +N +S D L++ L D ++R +AKE ++H + Sbjct: 238 --------------------QNPEKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >5D9K-A nrPDB Length = 330 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 69/315 (21%), Positives = 132/315 (41%), Gaps = 60/315 (19%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNN---ERVVVKILKPV-----KKKKIKREVKIL 86 + ++L++ LG+G + +VF I+ + + +K+LK + + K E IL Sbjct: 27 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDIL 86 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLK 143 + I+KL + L+ +++ D + T+ D++FY+ EL Sbjct: 87 VEV-NHPFIVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 143 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFKGPE 202 ALD+ HS GI++RD+KP N+++D ++ ++L D+GL++ ++ + + PE Sbjct: 144 ALDHLHSLGIIYRDLKPENILLD-EEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPE 202 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 ++ + + + S D WS G ++ M+ PF G+D + + I K Sbjct: 203 VV-NRRGHTQSADWWSFGVLMFEMLTGTLPF-QGKDRKETMTMILK-------------- 246 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA-----K 317 +SPEA LL L + + RL A + Sbjct: 247 -----------------------AKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVE 283 Query: 318 EAMEHPYFYPVVKEQ 332 E H +F + + Sbjct: 284 EIKRHSFFSTIDWNK 298 >5N23-A nrPDB Length = 352 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 67/318 (21%), Positives = 127/318 (39%), Gaps = 58/318 (18%) Query: 27 YEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIK--- 80 +E+ + + D ++ +R LG G + V + +KIL K VK K+I+ Sbjct: 31 WESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL 90 Query: 81 REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFY 137 E +I + ++KL + KD + +V EY + + ++ RFY Sbjct: 91 NEKRI-QQAVNFPFLVKLEFSFKD--NSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFY 147 Query: 138 MYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY 197 +++ +Y HS +++RD+KP N++ID QQ +++ D+G A+ + + Sbjct: 148 AAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIKVADFGFAKRVK-GRTPWTLCGTPE 205 Query: 198 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 + PE+++ + Y+ ++D W+LG ++ M PFF Q ++Y Sbjct: 206 YLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQ--------------PIQIYE 250 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL--- 314 + + HF S + DLL LL+ D +R Sbjct: 251 KIVSGKVRFPSHF------------------------SSDLKDLLRNLLQVDLTKRFGNL 286 Query: 315 --TAKEAMEHPYFYPVVK 330 + H +F Sbjct: 287 KNGVNDIKNHKWFATTDW 304 >5X3F-B nrPDB Length = 393 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 70/339 (20%), Positives = 132/339 (38%), Gaps = 59/339 (17%) Query: 6 AGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNER 65 A V A + + +E + D + ++ LG G + V + + Sbjct: 52 AKKLNDVQAFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNH 111 Query: 66 VVVKIL---KPVKKKKIK---REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINN 119 +KIL K VK K+I+ E +IL+ + ++KL + KD + +V EY+ Sbjct: 112 YAMKILDKQKVVKLKQIEHTLNEKRILQAV-NFPFLVKLEFSFKD--NSNLYMVMEYVAG 168 Query: 120 TDFKQLYQI---LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLID 176 + + ++ RFY +++ +Y HS +++RD+KP N++ID QQ +++ D Sbjct: 169 GEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQVTD 227 Query: 177 WGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHG 236 +G A+ + + PE+++ + Y+ ++D W+LG ++ M PFF Sbjct: 228 FGFAKRVK--GRTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFAD 284 Query: 237 QDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSP 296 Q ++Y + + HF S Sbjct: 285 Q--------------PIQIYEKIVSGKVRFPSHF------------------------SS 306 Query: 297 EALDLLDKLLRYDHQQRL-----TAKEAMEHPYFYPVVK 330 + DLL LL+ D +R + H +F Sbjct: 307 DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDW 345 >4I6B-A nrPDB Length = 308 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 64/329 (19%), Positives = 142/329 (43%), Gaps = 56/329 (17%) Query: 31 VPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVK 84 P+ G + Y + LG+G +++ +E ++TNN+ KI+ KP +++KI +E++ Sbjct: 23 DPTTGKR--YSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIE 80 Query: 85 ILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYEL 141 + L ++++ +D + ++ EY + + + +LT+ ++R+Y+ ++ Sbjct: 81 LHRIL-HHKHVVQFYHYFED--KENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQI 137 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP-AQEYNVRVASRYFKG 200 + L Y H + I+HRD+K N I+ + +L++ D+GLA P + + Sbjct: 138 VSGLKYLHEQEILHRDLKLGNFFIN-ESMELKVGDFGLAARLEPLEHRRRTICGTPNYLS 196 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK 260 PE+L + Q + D+W+LGC++ +M+ R PF + +E Y ++ Sbjct: 197 PEVL-NKQGHGAESDIWALGCVMYTMLLGRPPF--------------ETTNLKETYRSIR 241 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 320 + + A L+ +L + + R + + + Sbjct: 242 EARYTMPSSLLAP------------------------AKHLIASMLSKNPEDRPSLDDII 277 Query: 321 EHPYFYP-VVKEQSQPCADNAVLSSGLTA 348 H +F ++ + V L++ Sbjct: 278 RHDFFTQGFTPDRLSSSCCHTVPDFHLSS 306 >4RA4-A nrPDB Length = 355 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 69/350 (19%), Positives = 127/350 (36%), Gaps = 62/350 (17%) Query: 19 LRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV---- 74 + E ++ D+ + LG+G + +V A E +KILK Sbjct: 1 ISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQ 60 Query: 75 --KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---IL 129 + E ++L L + +L + V EY+N D Q Sbjct: 61 DDDVECTMVEKRVLALLDKPPFLTQLHSCFQ--TVDRLYFVMEYVNGGDLMYHIQQVGKF 118 Query: 130 TDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQE 188 + FY E+ L + H +GI++RD+K NVM+D + +++ D+G+ + Sbjct: 119 KEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSE-GHIKIADFGMCKEHMMDGVT 177 Query: 189 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 + + PE++ YQ Y S+D W+ G +L M+ + PF G+D Sbjct: 178 TRTFCGTPDYIAPEIIA-YQPYGKSVDWWAYGVLLYEMLAGQPPF-DGEDE--------- 226 Query: 249 VLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRY 308 +EL+ + ++++ +S EA+ + L+ Sbjct: 227 ----DELFQSIMEHNVSYP------------------------KSLSKEAVSICKGLMTK 258 Query: 309 DHQQRLTA-----KEAMEHPYFYPVVKE-----QSQPCADNAVLSSGLTA 348 +RL ++ EH +F + E + QP V G Sbjct: 259 HPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVSGKGAEN 308 >5X8I-B nrPDB Length = 346 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 71/324 (21%), Positives = 147/324 (45%), Gaps = 43/324 (13%) Query: 39 DYQLVRKLGRGKYSEVFEAI-NITNNERVVVKILKPVKK--KKIKREVKILENLRG-GTN 94 Y++V LG G + +V E I + V VKI+K V + + + E+++LE+L N Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPN 73 Query: 95 ----IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKALD 146 +++++ + +VFE + + + + + IR Y++ K+++ Sbjct: 74 STFRCVQMLEWFEH--HGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVN 131 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKK------------------LRLIDWGLAEFYHPAQE 188 + HS + H D+KP N++ ++++D+G A + + Sbjct: 132 FLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY--DDEH 189 Query: 189 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 ++ V++R+++ PE+++ + D+WS+GC+L F D+ + L + + Sbjct: 190 HSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEYYLGFTVF-PTHDSKEHLAMMER 247 Query: 249 VLGTEELYGYLKK------YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPE-ALDL 301 +LG + K +H LD + G++ + + V E DL Sbjct: 248 ILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDL 307 Query: 302 LDKLLRYDHQQRLTAKEAMEHPYF 325 + K+L YD +R+T +EA++HP+F Sbjct: 308 IQKMLEYDPAKRITLREALKHPFF 331 >5J5T-A nrPDB Length = 370 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 58/304 (19%), Positives = 127/304 (41%), Gaps = 46/304 (15%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI---KREVKILENLRG 91 G+Q+D++L++++G G Y +V++A N+ E +K++K + ++E+ ++++ + Sbjct: 1 GSQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKH 60 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYC 148 NI+ + + E+ + +Y + L++ I + E L+ L Y Sbjct: 61 -PNIVAYFGSYLR--RDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYL 117 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPEL--LV 205 HSKG MHRD+K N+++ ++L D+G+ A+ + + + Y+ PE+ + Sbjct: 118 HSKGKMHRDIKGANILLT-DNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVE 176 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 Y+ D+W++G + + P F + +L +K Sbjct: 177 RKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMK----- 231 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 W N H + L + ++R TA++ ++HP+ Sbjct: 232 ----------------WSNSFH------------HFVKMALTKNPKKRPTAEKLLQHPFV 263 Query: 326 YPVV 329 + Sbjct: 264 TQHL 267 >4WB7-A nrPDB Length = 405 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 67/318 (21%), Positives = 129/318 (40%), Gaps = 59/318 (18%) Query: 27 YEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIK--- 80 +E+ + + D ++ ++ LG G + V + +KIL K VK K+I+ Sbjct: 85 WESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTL 144 Query: 81 REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFY 137 E +IL+ + ++KL + KD + +V EY+ + + ++ RFY Sbjct: 145 NEKRILQAV-NFPFLVKLEFSFKD--NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFY 201 Query: 138 MYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY 197 +++ +Y HS +++RD+KP N++ID QQ +++ D+G A+ + Sbjct: 202 AAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRVK--GRTWTLCGTPE 258 Query: 198 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 + PE+++ + Y+ ++D W+LG ++ M PFF Q ++Y Sbjct: 259 YLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQ--------------PIQIYE 303 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL--- 314 + + HF S + DLL LL+ D +R Sbjct: 304 KIVSGKVRFPSHF------------------------SSDLKDLLRNLLQVDLTKRFGNL 339 Query: 315 --TAKEAMEHPYFYPVVK 330 + H +F Sbjct: 340 KNGVNDIKNHKWFATTDW 357 >3ORZ-A nrPDB Length = 316 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 74/313 (23%), Positives = 128/313 (40%), Gaps = 61/313 (19%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKI------LKPVKKKKIKREVKILENLRG 91 +D++ + LG G +S V A + + +KI +K K + RE ++ L Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-D 95 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYC 148 +KL +D + Y N + + + + RFY E++ AL+Y Sbjct: 96 HPFFVKLYFCFQD--DEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYL 153 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE---YNVRVASRYFKGPELLV 205 H KGI+HRD+KP N++++ + +++ D+G A+ P + N V + + PELL Sbjct: 154 HGKGIIHRDLKPENILLN-EDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT 212 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 + S D+W+LGC++ ++ PF G + ++ + K D Sbjct: 213 EKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYL--------------IFQKIIKLEYD 257 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE------A 319 F P+A DL++KLL D +RL +E Sbjct: 258 FPEKFF------------------------PKARDLVEKLLVLDATKRLGCEEMEGYGPL 293 Query: 320 MEHPYFYPVVKEQ 332 HP+F V E Sbjct: 294 KAHPFFESVTWEN 306 >3LM0-A nrPDB Length = 327 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 63/328 (19%), Positives = 138/328 (42%), Gaps = 57/328 (17%) Query: 33 SWGNQDDYQLV--RKLGRGKYSEVFEAINITNNERVVVKILKPVKK-----KKIKREVKI 85 S N +++ ++ ++LGRGK++ V + I+ + + K LK ++ +I E+ + Sbjct: 22 SMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAV 81 Query: 86 LENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD-----FKQLYQILTDFDIRFYMYE 140 LE + +I L + ++ L+ EY + +L +++++ D+ + + Sbjct: 82 LELAKSCPRVINLHEVYENTSE--IILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQ 139 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDH--QQKKLRLIDWGLAEFYHPAQEYNVRVASRYF 198 +L+ + Y H I+H D+KP N+++ ++++D+G++ A E + + + Sbjct: 140 ILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEY 199 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258 PE+L +Y + DMW++G + ++ PF G+DN + + I++V Sbjct: 200 LAPEIL-NYDPITTATDMWNIGIIAYMLLTHTSPFV-GEDNQETYLNISQV--------- 248 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE 318 E VS A D + LL + ++R TA+ Sbjct: 249 ------------------------NVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEI 284 Query: 319 AMEHPYFYP------VVKEQSQPCADNA 340 + H + E++ + Sbjct: 285 CLSHSWLQQWDFENLFHPEETSSSSQTQ 312 >2OU7-A nrPDB Length = 335 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 62/301 (20%), Positives = 128/301 (42%), Gaps = 53/301 (17%) Query: 46 LGRGKYSEVFEAINITNNERVVVKI------LKPVKKKKIKREVKILENLRGGTNIIKLI 99 LG+G +++ FE + E KI LKP +++K+ E+ I +L +++ Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQ-HVVGFH 107 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYCHSKGIMHR 156 +D + +V E +L++ LT+ + R+Y+ +++ Y H ++HR Sbjct: 108 GFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 165 Query: 157 DVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLD 215 D+K N+ ++ + ++++ D+GLA + + + V + + PE+L + + + +D Sbjct: 166 DLKLGNLFLN-EDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVD 223 Query: 216 MWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILG 275 +WS+GC++ +++ + PF + +E Y +KK + H N Sbjct: 224 VWSIGCIMYTLLVGKPPF--------------ETSCLKETYLRIKKNEYSIPKHIN---- 265 Query: 276 QHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQP 335 P A L+ K+L+ D R T E + +F P Sbjct: 266 --------------------PVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLP 305 Query: 336 C 336 Sbjct: 306 I 306 >4J52-A nrPDB Length = 293 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 62/301 (20%), Positives = 128/301 (42%), Gaps = 53/301 (17%) Query: 46 LGRGKYSEVFEAINITNNERVVVKI------LKPVKKKKIKREVKILENLRGGTNIIKLI 99 LG+G +++ FE + E KI LKP +++K+ E+ I +L +++ Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQ-HVVGFH 80 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYCHSKGIMHR 156 +D + +V E +L++ LT+ + R+Y+ +++ Y H ++HR Sbjct: 81 GFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 138 Query: 157 DVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLD 215 D+K N+ ++ + ++++ D+GLA + + + V + + PE+L + + + +D Sbjct: 139 DLKLGNLFLN-EDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVD 196 Query: 216 MWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILG 275 +WS+GC++ +++ + PF + +E Y +KK + H N Sbjct: 197 VWSIGCIMYTLLVGKPPF--------------ETSCLKETYLRIKKNEYSIPKHIN---- 238 Query: 276 QHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQP 335 P A L+ K+L+ D R T E + +F P Sbjct: 239 --------------------PVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLP 278 Query: 336 C 336 Sbjct: 279 I 279 >3HKO-A nrPDB Length = 345 Score = 226 bits (577), Expect = 8e-60, Method: Composition-based stats. Identities = 71/355 (20%), Positives = 128/355 (36%), Gaps = 95/355 (26%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI--------LKPVKKKKIKREVKIL 86 Q Y L +G+G Y V AI +KI + P ++IK EV+++ Sbjct: 23 ELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLM 82 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL----------------- 129 + L NI +L + +D + LV E + + Sbjct: 83 KKL-HHPNIARLYEVYED--EQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQI 139 Query: 130 --------------------------TDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNV 163 + I M ++ AL Y H++GI HRD+KP N Sbjct: 140 CPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENF 199 Query: 164 MID-HQQKKLRLIDWGLAEFYHPAQE-----YNVRVASRYFKGPELLV-DYQMYDYSLDM 216 + ++ +++L+D+GL++ ++ + + YF PE+L + Y D Sbjct: 200 LFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDA 259 Query: 217 WSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQ 276 WS G +L ++ PF G ++ D + ++ Sbjct: 260 WSAGVLLHLLLMGAVPF-PGVNDADTISQVLN---------------------------- 290 Query: 277 HSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKE 331 + + N +++SP A DLL LL + +R A A++HP+ + Sbjct: 291 -----KKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSDK 340 >4YNZ-A nrPDB Length = 342 Score = 226 bits (577), Expect = 8e-60, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 136/311 (43%), Gaps = 53/311 (17%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK-----KIKREVKILENLRGGTN 94 Y+L + LG+G+ V I+ ++V +KI+ K K++RE+ IL+ L + Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILK-LIEHPH 70 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSK 151 ++KL D ++ K LV E+++ + LT + R + +++ ALD+CHS Sbjct: 71 VLKLHDVYEN--KKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSH 128 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYD 211 I HRD+KP N+++D ++ +R+ D+G+A S ++ PE++ + Sbjct: 129 SICHRDLKPENLLLD-ERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 187 Query: 212 YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFN 271 D+WS G +L +++ PF DN QL+ +K+ + Sbjct: 188 RKADVWSCGVILFALLVGALPF--DDDNLRQLL------------EKVKRGVFHMP---- 229 Query: 272 DILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKE 331 H + P+ LL ++ D +RLT + +H + + Sbjct: 230 --------------------HFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIW---YIGG 266 Query: 332 QSQPCADNAVL 342 +++P + + Sbjct: 267 KNEPEPEQPIP 277 >6FYV-A nrPDB Length = 337 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 72/326 (22%), Positives = 150/326 (46%), Gaps = 43/326 (13%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINIT-NNERVVVKILKPV--KKKKIKREVKILENLRG-G 92 + Y++V LG G + +V E I+ + V VKI+K V ++ + E+++LE+L Sbjct: 13 RARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTD 72 Query: 93 TN----IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKA 144 N +++++ +VFE + + + + + IR Y++ ++ Sbjct: 73 PNSVFRCVQMLEWFDH--HGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQS 130 Query: 145 LDYCHSKGIMHRDVKPHNVMI------------------DHQQKKLRLIDWGLAEFYHPA 186 +++ H + H D+KP N++ + ++++D+G A + Sbjct: 131 INFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSAT--YDD 188 Query: 187 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRI 246 + ++ V++R+++ PE+++ + D+WS+GC+L F D+ + L + Sbjct: 189 EHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFTVF-QTHDSKEHLAMM 246 Query: 247 AKVLGTEELYGYLKK------YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEAL- 299 ++LG + K +H LD + G++ R+R + H E L Sbjct: 247 ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLF 306 Query: 300 DLLDKLLRYDHQQRLTAKEAMEHPYF 325 DL+ ++L YD QR+T EA++HP+F Sbjct: 307 DLVRRMLEYDPTQRITLDEALQHPFF 332 >2Z7Q-A nrPDB Length = 321 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 65/315 (20%), Positives = 130/315 (41%), Gaps = 60/315 (19%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINI---TNNERVVVKILKPV-----KKKKIKREVKIL 86 + ++L++ LG+G + +VF + + +K+LK + + K E IL Sbjct: 25 ADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDIL 84 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLK 143 ++ ++KL + L+ +++ D + T+ D++FY+ EL Sbjct: 85 ADV-NHPFVVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 141 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFKGPE 202 LD+ HS GI++RD+KP N+++D ++ ++L D+GL++ ++ + + PE Sbjct: 142 GLDHLHSLGIIYRDLKPENILLD-EEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 200 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 ++ + Q + +S D WS G ++ M+ PF G+D + + I K Sbjct: 201 VV-NRQGHSHSADWWSYGVLMFEMLTGSLPF-QGKDRKETMTLILK-------------- 244 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL-----TAK 317 +S EA LL L + + RL A+ Sbjct: 245 -----------------------AKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAE 281 Query: 318 EAMEHPYFYPVVKEQ 332 E H ++ + + Sbjct: 282 EIKRHVFYSTIDWNK 296 >6HXF-B nrPDB Length = 302 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 73/324 (22%), Positives = 142/324 (43%), Gaps = 51/324 (15%) Query: 22 REYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR 81 R+ +YE + +++V +LG G + +V++A N K+++ +++++ Sbjct: 3 RKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELED 62 Query: 82 ---EVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD----FKQLYQILTDFDI 134 E++IL I+KL+ ++ E+ +L + LT+ I Sbjct: 63 YIVEIEILATC-DHPYIVKLLGAYYH--DGKLWIMIEFCPGGAVDAIMLELDRGLTEPQI 119 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRV 193 + ++L+AL++ HSK I+HRD+K NV++ + +RL D+G+ A+ Q+ + + Sbjct: 120 QVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLE-GDIRLADFGVSAKNLKTLQKRDSFI 178 Query: 194 ASRYFKGPELL----VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKV 249 + Y+ PE++ + YDY D+WSLG L M + EP H + L++IAK Sbjct: 179 GTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMA-QIEPPHHELNPMRVLLKIAK- 236 Query: 250 LGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYD 309 +D + +W S E D L L + Sbjct: 237 ---------------------SDPPTLLTPSKW------------SVEFRDFLKIALDKN 263 Query: 310 HQQRLTAKEAMEHPYFYPVVKEQS 333 + R +A + +EHP+ + ++ Sbjct: 264 PETRPSAAQLLEHPFVSSITSNKA 287 >5DYK-A nrPDB Length = 853 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 72/326 (22%), Positives = 138/326 (42%), Gaps = 57/326 (17%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVK------ILKPVKKKKIKREVKILENLR 90 D+ + R +GRG + V + R +K I+ ++ IK E +I Sbjct: 538 MDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAE-N 596 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL---TDFDIRFYMYELLKALDY 147 II+L+ T KD SK + E + + + L + +FY+ ++ A++Y Sbjct: 597 DHPFIIRLVRTFKD--SKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEY 654 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 H + I++RD+KP N+++D +Q ++LID+G A+ V + ++ PE+++ Sbjct: 655 LHERNIVYRDLKPENILLD-KQGYVKLIDFGCAKKVQ--GRAYTLVGTPHYMAPEVILG- 710 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 + Y ++D+W+LG L I PF G D DQL E++ + + Sbjct: 711 KGYGCTVDIWALGICLYEFICGPLPF--GNDEEDQL----------EIFRDILTGQLTFP 758 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA-----KEAMEH 322 + D ++++L+ +LL Q R+ K+ +H Sbjct: 759 DYVTDT-----------------------DSINLMKRLLCRLPQGRIGCSINGFKDIKDH 795 Query: 323 PYFYPVVKEQ-SQPCADNAVLSSGLT 347 P+F ++ + D ++S T Sbjct: 796 PFFSNFNWDKLAGRLLDPPLVSKSET 821 >3A8W-A nrPDB Length = 345 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 128/315 (40%), Gaps = 53/315 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV---KKKKI---KREVKILENLRG 91 D+ L+R +GRG Y++V + +K++K + I + E + E Sbjct: 9 QDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN 68 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFK---QLYQILTDFDIRFYMYELLKALDYC 148 ++ L + V EY+N D Q + L + RFY E+ AL+Y Sbjct: 69 HPFLVGLHSCFQ--TESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYL 126 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFKGPELLVDY 207 H +GI++RD+K NV++D + ++L D+G+ + P + + + PE+L Sbjct: 127 HERGIIYRDLKLDNVLLDSE-GHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG- 184 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPF--FHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 + Y +S+D W+LG ++ M+ R PF DN DQ + L+ + + I Sbjct: 185 EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTE-------DYLFQVILEKQIR 237 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA------KEA 319 + +S +A +L L D ++RL + Sbjct: 238 IP------------------------RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADI 273 Query: 320 MEHPYFYPVVKEQSQ 334 HP+F V + + Sbjct: 274 QGHPFFRNVDWDMME 288 >3RAW-A nrPDB Length = 381 Score = 223 bits (569), Expect = 7e-59, Method: Composition-based stats. Identities = 73/331 (22%), Positives = 148/331 (44%), Gaps = 39/331 (11%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNE-RVVVKILKPV--KKKKIKREVKILENLRGGT 93 Q+ Y++V LG G + +V E ++ + +V +KI++ V ++ + E+ +L+ ++ Sbjct: 50 QERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKD 109 Query: 94 NIIKLIDTVKDP---VSKTPALVFEYINNTDFKQL----YQILTDFDIRFYMYELLKALD 146 K + + + FE + F+ L +Q +R Y+L AL Sbjct: 110 KENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALR 169 Query: 147 YCHSKGIMHRDVKPHNVMI------------------DHQQKKLRLIDWGLAEFYHPAQE 188 + H + H D+KP N++ + +R+ D+G A F H + Sbjct: 170 FLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDH--EH 227 Query: 189 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 + VA+R+++ PE++++ + D+WS+GC+L +R F +N + LV + K Sbjct: 228 HTTIVATRHYRPPEVILELG-WAQPCDVWSIGCILFEY-YRGFTLFQTHENREHLVMMEK 285 Query: 249 VLGTEELYGYLKK------YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSP-EALDL 301 +LG + + Y L N G++ ++ + + + + DL Sbjct: 286 ILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDL 345 Query: 302 LDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ 332 + ++L +D QR+T EA+ HP+F + E+ Sbjct: 346 MRRMLEFDPAQRITLAEALLHPFFAGLTPEE 376 >5DBX-A nrPDB Length = 328 Score = 223 bits (568), Expect = 9e-59, Method: Composition-based stats. Identities = 56/311 (18%), Positives = 115/311 (36%), Gaps = 53/311 (17%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGG 92 +D Y+L +G G + V A+ ERV +K + K + ++ +E++ + Sbjct: 10 RDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQC-SH 68 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----------ILTDFDIRFYMYEL 141 N++ + V LV + ++ + + +L + I + E+ Sbjct: 69 PNVVTYYTSF--VVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEV 126 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN------VRVAS 195 L+ LDY H G +HRD+K N+++ + +++ D+G++ F + V + Sbjct: 127 LEGLDYLHRNGQIHRDLKAGNILLG-EDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGT 185 Query: 196 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEEL 255 + PE++ + YD+ DMWS G + P+ + Sbjct: 186 PCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYH----------------KYPPM 229 Query: 256 YGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT 315 + D + + K++ LL L+ D +R T Sbjct: 230 KVLMLTLQNDPPTLETGVEDKEMMKKYGK------------SFRKLLSLCLQKDPSKRPT 277 Query: 316 AKEAMEHPYFY 326 A E ++ +F Sbjct: 278 AAELLKCKFFQ 288 >6E2O-A nrPDB Length = 295 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 62/331 (18%), Positives = 127/331 (38%), Gaps = 51/331 (15%) Query: 18 SLRSREYWDYEAHVPSWGNQDDYQLVRK-LGRGKYSEVFEAINITNNERVVVKILKPVKK 76 RS E D E+ + + + D R LG+G Y V+ +++N R+ +K + Sbjct: 1 GSRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDS 60 Query: 77 ---KKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL---- 129 + + E+ + ++L+ NI++ + + + + + E + L + Sbjct: 61 RYSQPLHEEIALHKHLKH-KNIVQYLGSFSE--NGFIKIFMEQVPGGSLSALLRSKWGPL 117 Query: 130 --TDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ 187 + I FY ++L+ L Y H I+HRD+K NV+I+ L++ D+G ++ Sbjct: 118 KDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGIN 177 Query: 188 EYN-VRVASRYFKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR 245 + + PE++ + Y + D+WSLGC + M + PF+ + + + Sbjct: 178 PCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFK 237 Query: 246 IAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKL 305 + E+ + S EA + K Sbjct: 238 VGMFKVHPEIPESM-----------------------------------SAEAKAFILKC 262 Query: 306 LRYDHQQRLTAKEAMEHPYFY-PVVKEQSQP 335 D +R A + + + K+++QP Sbjct: 263 FEPDPDKRACANDLLVDEFLKVSSKKKKTQP 293 >6E9W-A nrPDB Length = 443 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 69/305 (22%), Positives = 118/305 (38%), Gaps = 55/305 (18%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVK------ILKPVKKKKIKREVKILENLRG 91 +DY++V+ +GRG + EV + + + +K ++K E I+ Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMA-FAN 160 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL--TDFDIRFYMYELLKALDYCH 149 +++L +D + +V EY+ D L + RFY E++ ALD H Sbjct: 161 SPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIH 218 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ--EYNVRVASRYFKGPELLV-- 205 S G +HRDVKP N+++D + L+L D+G + + V + + PE+L Sbjct: 219 SMGFIHRDVKPDNMLLD-KSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQ 277 Query: 206 -DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 Y D WS+G L M+ PF+ ++GT K Sbjct: 278 GGDGYYGRECDWWSVGVFLYEMLVGDTPFYADS-----------LVGTYSKIMNHK---- 322 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL---TAKEAME 321 N + + + +S EA +L+ L D + RL +E Sbjct: 323 -------------------NSLTFPDDNDISKEAKNLICAFLT-DREVRLGRNGVEEIKR 362 Query: 322 HPYFY 326 H +F Sbjct: 363 HLFFK 367 >3PFQ-A nrPDB Length = 674 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 66/320 (20%), Positives = 119/320 (37%), Gaps = 62/320 (19%) Query: 35 GNQD-----DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV------KKKKIKREV 83 GN+D D+ + LG+G + +V + +E VKILK + E Sbjct: 333 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 392 Query: 84 KILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYE 140 ++L + +L + V EY+N D Q + FY E Sbjct: 393 RVLALPGKPPFLTQLHSCFQ--TMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAE 450 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFK 199 + L + SKGI++RD+K NVM+D + +++ D+G+ + + + Sbjct: 451 IAIGLFFLQSKGIIYRDLKLDNVMLDSE-GHIKIADFGMCKENIWDGVTTKTFCGTPDYI 509 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE++ YQ Y S+D W+ G +L M+ + PF G+D + I + Sbjct: 510 APEIIA-YQPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQSIME----------- 556 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA--- 316 + +S EA+ + L+ +RL Sbjct: 557 --------------------------HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPE 590 Query: 317 --KEAMEHPYFYPVVKEQSQ 334 ++ EH +F + E+ + Sbjct: 591 GERDIKEHAFFRYIDWEKLE 610 >2XIK-A nrPDB Length = 294 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 123/308 (39%), Gaps = 49/308 (15%) Query: 33 SWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK----PVKKKKIKREVKILEN 88 ++ + + ++G+G + EV++ I+ E V +KI+ + + I++E+ +L Sbjct: 14 RVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQ 73 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI--LTDFDIRFYMYELLKALD 146 I + + ++ EY+ L + L + I + E+LK LD Sbjct: 74 C-DSPYITRYFGSYLKSTK--LWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLD 130 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNVRVASRYFKGPELLV 205 Y HS+ +HRD+K NV++ +Q ++L D+G+A Q + N V + ++ PE++ Sbjct: 131 YLHSERKIHRDIKAANVLLS-EQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI- 188 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 YD+ D+WSLG + P + D Sbjct: 189 KQSAYDFKADIWSLGITAIELAKGEPP------------------------------NSD 218 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 L P L + H S + ++ L D + R TAKE ++H + Sbjct: 219 LHPMRVLFLIPKNSPPTLEGQH-------SKPFKEFVEACLNKDPRFRPTAKELLKHKFI 271 Query: 326 YPVVKEQS 333 K+ S Sbjct: 272 TRYTKKTS 279 >3TKU-A nrPDB Length = 433 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 70/316 (22%), Positives = 121/316 (38%), Gaps = 57/316 (18%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENL 89 +++D+++++ +GRG + EV +KIL K + + E +L N Sbjct: 88 HREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVN- 146 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKAL 145 I L +D LV +Y D L L + RFY+ E++ A+ Sbjct: 147 GDCQWITALHYAFQD--ENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAI 204 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ--EYNVRVASRYFKGPEL 203 D H +HRD+KP NV++D +RL D+G + + +V V + + PE+ Sbjct: 205 DSIHQLHYVHRDIKPDNVLLDV-NGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEI 263 Query: 204 LV----DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 L Y D WSLG + M++ PF+ + + +I Sbjct: 264 LQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYA-ESLVETYGKIMN----------- 311 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL---TA 316 E F + VS EA DL+ +L+ ++RL Sbjct: 312 ---------------------HEERFQFPSHVTDVSEEAKDLIQRLIC-SRERRLGQNGI 349 Query: 317 KEAMEHPYFYPVVKEQ 332 ++ +H +F + E Sbjct: 350 EDFKKHAFFEGLNWEN 365 >3M42-A nrPDB Length = 299 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 123/315 (39%), Gaps = 64/315 (20%) Query: 38 DDYQLV-RKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNII 96 DDY++ + LG G +V + N E+ +K+L K +REV++ +I+ Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIV 74 Query: 97 KLIDTVKD--PVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKALDYCH 149 +++D ++ K +V E ++ + Q T+ + M + +A+ Y H Sbjct: 75 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 150 SKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 S I HRDVKP N++ ++ L+L D+G A+ Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET----------------------TG 172 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 + YD S DMWSLG ++ ++ PF+ + + I+ + T G + Sbjct: 173 EKYDKSCDMWSLGVIMYILLCGYPPFYS-----NHGLAISPGMKTRIRMGQYE------- 220 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 + VS E L+ LL+ + QR+T E M HP+ Sbjct: 221 ------------------FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 262 Query: 328 VVKEQSQPCADNAVL 342 K P + VL Sbjct: 263 STKVPQTPLHTSRVL 277 >4C0T-A nrPDB Length = 974 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 124/313 (39%), Gaps = 61/313 (19%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKKIKR---EVKILENL 89 N D++ ++LG G YS V A + ++ VK+L +K+KK+K E L L Sbjct: 264 NVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRL 323 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL---YQILTDFDIRFYMYELLKALD 146 +I L T +D + V +Y +N + L Y L + R + ++L A+ Sbjct: 324 SNRLGVISLYFTFQD--KDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY----------NVRVASR 196 Y H G++HRD+KP N+++D + ++++ D+G A + V + Sbjct: 382 YMHDNGVIHRDLKPENILLDDKM-RIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTA 440 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY 256 + PELL + + D+W+ GC++ MI + PF + + Sbjct: 441 EYVSPELL-ENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYL--------------TF 485 Query: 257 GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA 316 + K F I+ DL+ K+L +R T Sbjct: 486 QKITKLQFAFSAGFPTII------------------------RDLIKKILVLQPSRRATI 521 Query: 317 KEAMEHPYFYPVV 329 E +H +F V Sbjct: 522 PEIQKHYFFQSVD 534 >6ED6-A nrPDB Length = 415 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 70/324 (21%), Positives = 120/324 (37%), Gaps = 57/324 (17%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVK------ILKPVKKKKIKREVKILENLRG 91 +DY +V+ +GRG + EV + + + +K ++K E I+ Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA-FAN 146 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL--TDFDIRFYMYELLKALDYCH 149 +++L +D + +V EY+ D L + +FY E++ ALD H Sbjct: 147 SPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIH 204 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ--EYNVRVASRYFKGPELLVDY 207 S G++HRDVKP N+++D + L+L D+G + V + + PE+L Sbjct: 205 SMGLIHRDVKPDNMLLD-KHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQ 263 Query: 208 QM---YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 Y D WS+G L M+ PF+ ++GT K Sbjct: 264 GGDGFYGRECDWWSVGVFLYEMLVGDTPFYADS-----------LVGTYSKIMDHK---- 308 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL---TAKEAME 321 N + +S A +L+ L D + RL +E + Sbjct: 309 -------------------NSLCFPEDAEISKHAKNLICAFLT-DREVRLGRNGVEEIRQ 348 Query: 322 HPYFY--PVVKEQSQPCADNAVLS 343 HP+F + + A V Sbjct: 349 HPFFKNDQWHWDNIRETAAPVVPE 372 >3NYO-A nrPDB Length = 576 Score = 220 bits (560), Expect = 8e-58, Method: Composition-based stats. Identities = 76/337 (22%), Positives = 134/337 (39%), Gaps = 55/337 (16%) Query: 8 SRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVV 67 S A ++S+ + ++ ++ ++ R LG+G + EV + Sbjct: 154 SVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYA 213 Query: 68 VKILKPVK------KKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD 121 K L+ + + E +ILE + ++ L + LV +N D Sbjct: 214 CKKLEKKRIKKRKGEAMALNEKQILEKV-NSRFVVSLAYAYE--TKDALCLVLTLMNGGD 270 Query: 122 FK-QLYQI----LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLID 176 K +Y + + FY E+ L+ H + I++RD+KP N+++D +R+ D Sbjct: 271 LKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHIRISD 329 Query: 177 WGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHG 236 GLA Q RV + + PE++ + + Y +S D W+LGC+L MI + PF Sbjct: 330 LGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER-YTFSPDWWALGCLLYEMIAGQSPFQQR 388 Query: 237 QDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSP 296 + K + EE+ +K+ + E SP Sbjct: 389 K----------KKIKREEVERLVKE------------------------VPEEYSERFSP 414 Query: 297 EALDLLDKLLRYDHQQRL-----TAKEAMEHPYFYPV 328 +A L +LL D +RL +A+E EHP F + Sbjct: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 >5FET-A nrPDB Length = 847 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 137/326 (42%), Gaps = 57/326 (17%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVK------ILKPVKKKKIKREVKILENLR 90 + + R +GRG + V + R +K I+ ++ IK E +I Sbjct: 532 MHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAE-N 590 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL---TDFDIRFYMYELLKALDY 147 II+L+ T KD S + E + + + L + +FY+ ++ A++Y Sbjct: 591 DHPFIIRLVRTFKD--SNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEY 648 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 H + I++RD+KP N+++D +Q ++LID+G A+ V + ++ PE+++ Sbjct: 649 LHERNIVYRDLKPENILLD-KQGYVKLIDFGCAKKIQ--GRAYTLVGTPHYMAPEVILG- 704 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 + Y ++D+W+LG L I PF G D DQL E++ + + Sbjct: 705 KGYGCTVDIWALGVCLYEFICGPLPF--GNDQEDQL----------EIFRDILTGQLTFP 752 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA-----KEAMEH 322 + +D ++++L+ +LL Q R+ K+ EH Sbjct: 753 DYVSD-----------------------QDSINLMKRLLCRLPQGRIGCSINGFKDIKEH 789 Query: 323 PYFYPVVKEQ-SQPCADNAVLSSGLT 347 +F ++ + + ++S G T Sbjct: 790 AFFGNFNWDKLAGRLLEPPLVSKGET 815 >5UNP-A nrPDB Length = 369 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 78/347 (22%), Positives = 151/347 (43%), Gaps = 44/347 (12%) Query: 30 HVPSWGNQDDYQLVRKLGRGKYSEVFEAI-NITNNERVVVKILKPVKK--KKIKREVKIL 86 HV W Q+ Y++V LG G + V + + + RV +KI+K V+K + + E+ +L Sbjct: 27 HVGDW-LQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVL 85 Query: 87 ENL--RGGTN---IIKLIDTVKDPVSKTPALVFEYINNTDFKQL----YQILTDFDIRFY 137 E + + N +++ D + FE + + F L Y +R Sbjct: 86 EKINEKDPDNKNLCVQMFDWF--DYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHM 143 Query: 138 MYELLKALDYCHSKGIMHRDVKPHNVMI------------------DHQQKKLRLIDWGL 179 ++L +A+ + H + H D+KP N++ + +R++D+G Sbjct: 144 AFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGS 203 Query: 180 AEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDN 239 A F H + ++ V++R+++ PE++++ + D+WS+GC++ F DN Sbjct: 204 ATFDH--EHHSTIVSTRHYRAPEVILELG-WSQPCDVWSIGCIIFEYYVGFT-LFQTHDN 259 Query: 240 YDQLVRIAKVLGTEELYGYLKK------YHIDLDPHFNDILGQHSRKRWENFIHSENRHL 293 + L + ++LG K Y LD N G++ R+ + Sbjct: 260 REHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEA 319 Query: 294 VSP-EALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADN 339 + DL++ +L Y+ +RLT EA++HP+F + E D+ Sbjct: 320 EEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDS 366 >2I0E-A nrPDB Length = 353 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 66/320 (20%), Positives = 119/320 (37%), Gaps = 62/320 (19%) Query: 35 GNQD-----DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV------KKKKIKREV 83 GN+D D+ + LG+G + +V + +E VKILK + E Sbjct: 12 GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 71 Query: 84 KILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYE 140 ++L + +L + V EY+N D Q + FY E Sbjct: 72 RVLALPGKPPFLTQLHSCFQ--TMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAE 129 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFK 199 + L + SKGI++RD+K NVM+D + +++ D+G+ + + + Sbjct: 130 IAIGLFFLQSKGIIYRDLKLDNVMLDSE-GHIKIADFGMCKENIWDGVTTKTFCGTPDYI 188 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE++ YQ Y S+D W+ G +L M+ + PF G+D + I + Sbjct: 189 APEIIA-YQPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDEDELFQSIME----------- 235 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA--- 316 + +S EA+ + L+ +RL Sbjct: 236 --------------------------HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPE 269 Query: 317 --KEAMEHPYFYPVVKEQSQ 334 ++ EH +F + E+ + Sbjct: 270 GERDIKEHAFFRYIDWEKLE 289 >4WNO-A nrPDB Length = 287 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 55/213 (25%), Positives = 104/213 (48%), Gaps = 22/213 (10%) Query: 39 DYQLVRK--LGRGKYSEVFEAINITNNE-RVVVKILKPVKKKKIK----REVKILENLRG 91 ++ RK +G G ++ VF+ + ++ V VK + K + +E+KIL+ L+ Sbjct: 17 KFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKH 76 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYC 148 NI+ L D + ++ + LV EY N D L++ IR ++ ++ A+ Sbjct: 77 -ENIVALYDFQE--MANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLL 133 Query: 149 HSKGIMHRDVKPHNVMIDHQQK--------KLRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 HSKGI+HRD+KP N+++ + ++++ D+G A + S + Sbjct: 134 HSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMA 193 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 PE+++ Q YD D+WS+G ++ + + PF Sbjct: 194 PEVIMS-QHYDGKADLWSIGTIVYQCLTGKAPF 225 >4QMW-A nrPDB Length = 310 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 60/298 (20%), Positives = 119/298 (39%), Gaps = 49/298 (16%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK----PVKKKKIKREVKILENLR 90 ++ + + K+G+G + EVF+ I+ + V +KI+ + + I++E+ +L Sbjct: 26 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQC- 84 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI--LTDFDIRFYMYELLKALDYC 148 + K + ++ EY+ L + L + I + E+LK LDY Sbjct: 85 DSPYVTKYYGSYLKDTK--LWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYL 142 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNVRVASRYFKGPELLVDY 207 HS+ +HRD+K NV++ + +++L D+G+A Q + N V + ++ PE++ Sbjct: 143 HSEKKIHRDIKAANVLLS-EHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-KQ 200 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 YD D+WSLG + P +K + Sbjct: 201 SAYDSKADIWSLGITAIELARGEPP--------------------HSELHPMKVLFLIPK 240 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 + + G +S+ + ++ L + R TAKE ++H + Sbjct: 241 NNPPTLEGNYSKP-----------------LKEFVEACLNKEPSFRPTAKELLKHKFI 281 >4U41-A nrPDB Length = 332 Score = 217 bits (553), Expect = 5e-57, Method: Composition-based stats. Identities = 55/310 (17%), Positives = 114/310 (36%), Gaps = 53/310 (17%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK--IKREVKILENLRGGTNIIK 97 ++LV +G G Y +V++ ++ + +K++ + ++ IK E+ +L+ NI Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIAT 85 Query: 98 LIDTVKDPV----SKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKALDYC 148 LV E+ L + L + I + E+L+ L + Sbjct: 86 YYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHL 145 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL-AEFYHPAQEYNVRVASRYFKGPELLVDY 207 H ++HRD+K NV++ + +++L+D+G+ A+ N + + Y+ PE++ Sbjct: 146 HIHHVIHRDIKGQNVLLT-ENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD 204 Query: 208 Q----MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 + YDY D+WS G M P Sbjct: 205 ENPDATYDYRSDLWSCGITAIEMAEGAPPLC----------------------------- 235 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 D+ P L + + ++ L ++ QR + ++ ++HP Sbjct: 236 -DMHPMRALFLIPRNPPPRLKSKKWSKKFFSF------IEGCLVKNYMQRPSTEQLLKHP 288 Query: 324 YFYPVVKEQS 333 + E+ Sbjct: 289 FIRDQPNERQ 298 >4AW2-A nrPDB Length = 437 Score = 217 bits (552), Expect = 7e-57, Method: Composition-based stats. Identities = 68/316 (21%), Positives = 121/316 (38%), Gaps = 57/316 (18%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENL 89 +++D+++++ +GRG + EV ++ +KIL K + + E +L N Sbjct: 72 HREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVN- 130 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKAL 145 I L +D LV +Y D L L + RFY+ E++ A+ Sbjct: 131 GDSKWITTLHYAFQD--DNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAI 188 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQ-EYNVRVASRYFKGPEL 203 D H +HRD+KP N+++D +RL D+G + + +V V + + PE+ Sbjct: 189 DSVHQLHYVHRDIKPDNILMD-MNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEI 247 Query: 204 LV----DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 L Y D WSLG + M++ PF+ + + +I Sbjct: 248 LQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYA-ESLVETYGKIMN----------- 295 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL---TA 316 E F VS A DL+ +L+ + RL Sbjct: 296 ---------------------HKERFQFPTQVTDVSENAKDLIRRLIC-SREHRLGQNGI 333 Query: 317 KEAMEHPYFYPVVKEQ 332 ++ +HP+F + + Sbjct: 334 EDFKKHPFFSGIDWDN 349 >6BDL-A nrPDB Length = 347 Score = 217 bits (552), Expect = 7e-57, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 128/308 (41%), Gaps = 56/308 (18%) Query: 39 DYQLVRKLGRGKYSEVFEAINI-TNNERVVVKILKPV------KKKKIKREVKILENLRG 91 D+ ++ LG G + V ++ +KILK +++ I+ E +I++ Sbjct: 35 DFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG-AH 93 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYC 148 I++L T KD SK ++ E + + + D RFY +++A Y Sbjct: 94 SDFIVRLYRTFKD--SKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYL 151 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQ 208 HSKGI++RD+KP N+++DH+ +L+D+G A+ ++ + + PE++++ + Sbjct: 152 HSKGIIYRDLKPENLILDHR-GYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILN-K 209 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 +D S D WSLG ++ ++ PF G D I + + E + K Sbjct: 210 GHDISADYWSLGILMYELLTGSPPF-SGPDPMKTYNIILRGIDMIEFPKKIAK------- 261 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL-----TAKEAMEHP 323 A +L+ KL R + +RL K+ +H Sbjct: 262 ----------------------------NAANLIKKLCRDNPSERLGNLKNGVKDIQKHK 293 Query: 324 YFYPVVKE 331 +F E Sbjct: 294 WFEGFNWE 301 >6QAU-A nrPDB Length = 280 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 69/305 (22%), Positives = 130/305 (42%), Gaps = 55/305 (18%) Query: 39 DYQLVRKLGRGKYSEVFEAINI-TNNERVVVKIL--KPVKKKKIK--REVKILENLRGGT 93 +Y +G G ++ VF + + V +K + K + K +I +E+KIL+ L+ Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQH-E 70 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHS 150 NI+ L D + P S LV EY N D Q L++ IR +++++ A+ HS Sbjct: 71 NIVALYDVQELPNS--VFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHS 128 Query: 151 KGIMHRDVKPHNVMIDHQQK--------KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 202 KGI+HRD+KP N+++ + + ++++ D+G A + H S + PE Sbjct: 129 KGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPE 188 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 +++ Q YD D+WS+G ++ + + PF Q N Q +R+ E+ + Sbjct: 189 VIMS-QHYDAKADLWSIGTVIYQCLVGKPPF---QANSPQDLRMF----YEKNRSLMPSI 240 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 + P+ ++L + + + R+ + H Sbjct: 241 PRETSPYLANLLLGLL----------------------------QRNQKDRMDFEAFFSH 272 Query: 323 PYFYP 327 P+ Sbjct: 273 PFLEQ 277 >4FZF-B nrPDB Length = 283 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 116/306 (37%), Gaps = 49/306 (16%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK----PVKKKKIKREVKILENLR 90 ++ + + ++G+G + EVF+ I+ + V +KI+ + + I++E+ +L Sbjct: 5 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 64 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDYC 148 + K + ++ EY+ L + +F I + E+LK LDY Sbjct: 65 SSY-VTKYYGSYLK--GSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 121 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNVRVASRYFKGPELLVDY 207 HS+ +HRD+K NV++ +Q ++L +G+A Q + N V + ++ PE++ Sbjct: 122 HSEKKIHRDIKAANVLLS-EQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQ- 179 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 YD D+WSLG + P Sbjct: 180 SAYDSKADIWSLGITAIELAKGEPP----------------------------------- 204 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 +D+ + + +D L D R TAKE ++H + Sbjct: 205 --NSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVK 262 Query: 328 VVKEQS 333 K+ S Sbjct: 263 NSKKTS 268 >2JD5-A nrPDB Length = 373 Score = 216 bits (551), Expect = 9e-57, Method: Composition-based stats. Identities = 82/342 (23%), Positives = 146/342 (42%), Gaps = 37/342 (10%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGTN-- 94 Y LVRKLG G +S V+ A ++ NN V +KI++ V + + E+K+L+ + N Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTK 79 Query: 95 --------IIKLIDTV--KDPVSKTPALVFEYINNTDF----KQLYQILTDFDIRFYMYE 140 I+KL+D K P +VFE + K ++ + ++ + Sbjct: 80 EDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQ 139 Query: 141 LLKALDYCHSK-GIMHRDVKPHNVMIDHQQK-----KLRLIDWGLAEFYHPAQEYNVRVA 194 LL LDY H + GI+H D+KP NV+++ ++++ D G A +Y + Y + Sbjct: 140 LLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY--DEHYTNSIQ 197 Query: 195 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQ-----DNYDQLVRIAKV 249 +R ++ PE+L+ + D+WS C++ +I F + + D + +I ++ Sbjct: 198 TREYRSPEVLLGA-PWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIEL 256 Query: 250 LG-TEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS-PEAL---DLLDK 304 LG KY + K W ++ S EA D L Sbjct: 257 LGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLSP 316 Query: 305 LLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGL 346 +L+ D ++R A + HP+ + + D + SG Sbjct: 317 MLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGS 358 >4CRL-A nrPDB Length = 406 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 79/334 (23%), Positives = 152/334 (45%), Gaps = 44/334 (13%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNER--VVVKILKPVKKKK-IKREVKILENLRGGTNI 95 +Y+ + GRG Y V++A + +K ++ RE+ +L L+ N+ Sbjct: 24 EYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKH-PNV 81 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI------------LTDFDIRFYMYELLK 143 I L + L+F+Y + D + + L ++ +Y++L Sbjct: 82 ISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILD 140 Query: 144 ALDYCHSKGIMHRDVKPHNVMI---DHQQKKLRLIDWGLAEFYH----PAQEYNVRVASR 196 + Y H+ ++HRD+KP N+++ ++ ++++ D G A ++ P + + V + Sbjct: 141 GIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTF 200 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY--------DQLVRIAK 248 +++ PELL+ + Y ++D+W++GC+ A ++ F Q++ DQL RI Sbjct: 201 WYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFN 260 Query: 249 VLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWEN--FIHSENRHLVSPE--ALDLLDK 304 V+G + I P + ++ R + N I +H V P+ A LL K Sbjct: 261 VMGFPADKDW---EDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQK 317 Query: 305 LLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCAD 338 LL D +R+T+++AM+ PYF E P +D Sbjct: 318 LLTMDPIKRITSEQAMQDPYFL----EDPLPTSD 347 >4B8L-A nrPDB Length = 286 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 127/298 (42%), Gaps = 53/298 (17%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK------IKREVKILENLRG 91 DD+ + R LG+GK+ V+ A N + +K+L + +K ++RE++I +LR Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYC 148 NI+++ + D K L+ E+ + + Q + +M EL AL YC Sbjct: 75 -PNILRMYNYFHD--RKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYC 131 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQ 208 H + ++HRD+KP N+++ ++ +L++ D+G + + P+ + + PE++ + + Sbjct: 132 HERKVIHRDIKPENLLMGYK-GELKIADFGWS-VHAPSLRRRTMCGTLDYLPPEMI-EGK 188 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 +D +D+W G + + PF E + + + P Sbjct: 189 THDEKVDLWCAGVLCYEFLVGMPPFDSPSHT--------------ETHRRIVNVDLKFPP 234 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 +D DL+ KLLRY QRL K MEHP+ Sbjct: 235 FLSDGS------------------------KDLISKLLRYHPPQRLPLKGVMEHPWVK 268 >4TNB-A nrPDB Length = 590 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 75/321 (23%), Positives = 120/321 (37%), Gaps = 55/321 (17%) Query: 22 REYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK--- 78 + ++ ++ ++ R LG+G + EV + K L+ + KK Sbjct: 168 DRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG 227 Query: 79 ---IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-----QILT 130 E +ILE + ++ L + LV +N D K Sbjct: 228 ESMALNEKQILEKVNSQ-FVVNLAYAYE--TKDALCLVLTIMNGGDLKFHIYNMGNPGFE 284 Query: 131 DFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN 190 + FY E+L L+ H + ++RD+KP N+++D +R+ D GLA Sbjct: 285 EERALFYAAEILCGLEDLHHENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIR 343 Query: 191 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVL 250 RV + + PE+L + Q Y S D W LGC++ MI + PF ++ + +VL Sbjct: 344 GRVGTVGYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVL 402 Query: 251 GTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDH 310 TEE+Y H S EA + LL D Sbjct: 403 ETEEVYS----------------------------------HKFSEEAKSICKMLLTKDA 428 Query: 311 QQRLT-----AKEAMEHPYFY 326 +QRL A E HP+F Sbjct: 429 KQRLGCQEEEAAEVKRHPFFR 449 >4AF3-A nrPDB Length = 292 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 70/313 (22%), Positives = 132/313 (42%), Gaps = 53/313 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENLRG 91 DD+++ R LG+GK+ V+ A ++ V +K+L K + +++RE++I +L Sbjct: 23 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHL-H 81 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYC 148 NI++L + D + L+ EY + + Q + M EL AL YC Sbjct: 82 HPNILRLYNYFYD--RRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC 139 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQ 208 H K ++HRD+KP N+ + + +L++ D+G + + P+ + + PE++ + + Sbjct: 140 HGKKVIHRDIKPENL-LLGLKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPEMI-EGR 196 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 M++ +D+W +G + ++ PF N E Y + K + Sbjct: 197 MHNEKVDLWCIGVLCYELLVGNPPFESASHN--------------ETYRRIVKVDLKFPA 242 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPV 328 A DL+ KLLR++ +RL + HP+ Sbjct: 243 SVPTG------------------------AQDLISKLLRHNPSERLPLAQVSAHPWVRAN 278 Query: 329 VKEQSQPCADNAV 341 + P A +V Sbjct: 279 SRRVLPPSALQSV 291 >1TKI-A nrPDB Length = 321 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 130/297 (43%), Gaps = 45/297 (15%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI--KREVKILENLRGGTNI 95 + Y + LGRG++ V + ++ + + K +K ++ K+E+ IL N+ NI Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISIL-NIARHRNI 63 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCHSK 151 + L ++ + ++FE+I+ D + L + +I Y++++ +AL + HS Sbjct: 64 LHLHESFESMEE--LVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSH 121 Query: 152 GIMHRDVKPHNVMI-DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 I H D++P N++ + +++I++G A P + + + + PE+ + + Sbjct: 122 NIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEV-HQHDVV 180 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 + DMWSLG ++ ++ PF + N + I Sbjct: 181 STATDMWSLGTLVYVLLSGINPFLA-ETNQQIIENIMNA--------------------- 218 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 E E +S EA+D +D+LL + + R+TA EA++HP+ Sbjct: 219 ------------EYTFDEEAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQ 263 >6CCF-A nrPDB Length = 290 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 61/323 (18%), Positives = 126/323 (39%), Gaps = 76/323 (23%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVV----------------------------- 68 + Y+L ++G+G Y V A N + + + Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 69 --KILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL- 125 K L P+ +++ +E+ IL+ L N++KLI+ + DP LVF+ + ++ Sbjct: 65 PAKQLLPL--ERVYQEIAILKKL-DHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVP 121 Query: 126 -YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFY 183 + ++ R Y+ +++ L+Y H + I+HRD+KP N+++ +++ D+G++ +F Sbjct: 122 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLG-DDGHVKIADFGVSNQFE 180 Query: 184 HPAQEYNVRVASRYFKGPELL--VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYD 241 + + + F PE + +LD+W+ G L ++ + PF Sbjct: 181 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF-------- 232 Query: 242 QLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDL 301 +D + RK + +S E DL Sbjct: 233 ----------------------------IDDFILALHRKIKNEPVVFPEEPEISEELKDL 264 Query: 302 LDKLLRYDHQQRLTAKEAMEHPY 324 + K+L + + R+ + HP+ Sbjct: 265 ILKMLDKNPETRIGVPDIKLHPW 287 >6CQF-A nrPDB Length = 297 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 120/297 (40%), Gaps = 46/297 (15%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK---PVKKKKIKREVKILENLRG 91 +D Y L+++LG G Y EVF+A + + + V +K++K +++E+ IL+ R Sbjct: 13 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRH 72 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYC 148 NI+ + + + E+ + +YQ+ L++ I + E+L+ L Y Sbjct: 73 A-NIVAYHGSYL--WLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYL 129 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN-VRVASRYFKGPEL--LV 205 HS+ +HRD+K N++I+ ++RL D+G++ + + Y+ PE+ + Sbjct: 130 HSQKKIHRDIKGANILIN-DAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVA 188 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 Y+ D+WSLG + + P F +L Sbjct: 189 LKGGYNELCDIWSLGITAIELAELQPPLFDVH---------------PLRVLFLMTKSGY 233 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 P + + +W H+ + L ++R +A + + H Sbjct: 234 QPPRLKE------KGKWSAAFHN------------FIKVTLTKSPKKRPSATKMLSH 272 >2BRG-A nrPDB Length = 297 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 121/297 (40%), Gaps = 49/297 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK----KKIKREVKILENLRGGT 93 +D+ LV+ LG G Y EV A+N E V VKI+ + + IK+E+ I + L Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKML-NHE 65 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYCHS 150 N++K L EY + + + + + D + + ++L+ + Y H Sbjct: 66 NVVKFYG--HRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE---YNVRVASRYFKGPELLVDY 207 GI HRD+KP N+++D + L++ D+GLA + N + + PELL Sbjct: 124 IGITHRDIKPENLLLDERD-NLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 + + +D+WS G +L +M+ P+ D+ + Y K+ L+ Sbjct: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQE-------------YSDWKEKKTYLN 229 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 P + L LL K+L + R+T + + + Sbjct: 230 P----------------------WKKIDSAPLALLHKILVENPSARITIPDIKKDRW 264 >5TQX-A nrPDB Length = 655 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 121/298 (40%), Gaps = 31/298 (10%) Query: 31 VPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI----LKPVKKKKIKREVKIL 86 P +G +++ +LG G + V + + ++ +K L +++ E++I+ Sbjct: 1 DPEFGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIM 60 Query: 87 ENLRGGTNIIKLIDTVKDP---VSKTPALVFEYINNTDFKQLYQI------LTDFDIRFY 137 + L N++K D ++ + P L EY + D ++L L + I Sbjct: 61 KKLNHA-NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSL 119 Query: 138 MYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL--RLIDWGLAEFYHPAQEYNVRVAS 195 + ++ + Y H I+HRD+KP N+++ K+ ++ID G A+ + V + Sbjct: 120 LSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGT 179 Query: 196 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEEL 255 + PE L + + Y ++D WS G M+ I PF H + +I K ++ Sbjct: 180 LQYLAPE-LFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKK----KDP 234 Query: 256 YGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR 313 + + F+ L Q + EN L +L +D QQR Sbjct: 235 KCIFACEEMSGEVRFSSHLPQPNSLCSLIVEPMENW----------LQLMLNWDPQQR 282 >4FR4-A nrPDB Length = 384 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 55/308 (17%), Positives = 123/308 (39%), Gaps = 51/308 (16%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK------KKIKREVKILENL 89 N D ++++R +G+G + +V + +K + K + + +E++I++ L Sbjct: 13 NFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGL 72 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALD 146 ++ L + +D +V + + D + Q + ++ ++ EL+ ALD Sbjct: 73 EH-PFLVNLWYSFQDEED--MFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALD 129 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVD 206 Y ++ I+HRD+KP N+++D + + + D+ +A + ++ + PE+ Sbjct: 130 YLQNQRIIHRDMKPDNILLD-EHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSS 188 Query: 207 YQ--MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 + Y +++D WSLG ++ R P+ I ++E+ + + Sbjct: 189 RKGAGYSFAVDWWSLGVTAYELLRGRRPY-----------HIRSSTSSKEIVHTFETTVV 237 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-AKEAMEHP 323 + S E + LL KLL + QR + + P Sbjct: 238 TYPSAW------------------------SQEMVSLLKKLLEPNPDQRFSQLSDVQNFP 273 Query: 324 YFYPVVKE 331 Y + + Sbjct: 274 YMNDINWD 281 >2WO6-A nrPDB Length = 382 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 75/342 (21%), Positives = 143/342 (41%), Gaps = 59/342 (17%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK--KKKIKREVKILENLRGGT- 93 D Y++ +G+G + +V +A + E V +KI+K K + + EV++LE + Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDT 112 Query: 94 ----NIIKLIDTVKDPVSKTPALVFEYINNTDFKQL----YQILTDFDIRFYMYELLKAL 145 I+ L LVFE ++ + L ++ ++ R + ++ AL Sbjct: 113 EMKYYIVHLKRHF--MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTAL 170 Query: 146 DYCH--SKGIMHRDVKPHNVMI-DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 202 + I+H D+KP N+++ + ++ ++++D+G + Q + SR+++ PE Sbjct: 171 LFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--GQRIYQYIQSRFYRSPE 228 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 +L+ YD ++DMWSLGC+L M EP F G + DQ+ +I +VLG + Sbjct: 229 VLLGM-PYDLAIDMWSLGCILVEMHTG-EPLFSGANEVDQMNKIVEVLGIPP------AH 280 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSP-------------------------- 296 +D P + W + + P Sbjct: 281 ILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESG 340 Query: 297 -------EALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKE 331 + DL+ ++L YD + R+ A++H +F E Sbjct: 341 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >2X7G-A nrPDB Length = 389 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 74/359 (20%), Positives = 142/359 (39%), Gaps = 75/359 (20%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILENLR----GG 92 Y ++RKLG G +S V+ ++ V +K++K + + E+K+L+ +R Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSD 91 Query: 93 TN---IIKLIDTVK--DPVSKTPALVFEYINNTDFKQL----YQILTDFDIRFYMYELLK 143 N +++LID K +VFE + + K + YQ L ++ + ++L+ Sbjct: 92 PNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQ 151 Query: 144 ALDYCHSK-GIMHRDVKPHNVMI------------------------------------- 165 LDY HSK I+H D+KP N+++ Sbjct: 152 GLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPAAD 211 Query: 166 ---------DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDM 216 + + ++++ D G A + H + + + +R ++ E+L+ Y D+ Sbjct: 212 LLVNPLDPRNADKIRVKIADLGNACWVH--KHFTEDIQTRQYRSIEVLIGA-GYSTPADI 268 Query: 217 WSLGCMLASMIFRREPFFH--GQD---NYDQLVRIAKVLGT-EELYGYLKKYHIDLDPHF 270 WS CM + F G+D + D + I ++LG+ + KY + Sbjct: 269 WSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRR 328 Query: 271 NDILGQHSRKRWENFI----HSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 ++ K W F H + + D L +L ++R +A E + HP+ Sbjct: 329 GELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL 387 >1U5R-A nrPDB Length = 348 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 125/296 (42%), Gaps = 54/296 (18%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVKILENLRGGT 93 + +R++G G + V+ A ++ N+E V +K + K + I +EV+ L+ LR Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH-P 114 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNT--DFKQLYQI-LTDFDIRFYMYELLKALDYCHS 150 N I+ T LV EY + D ++++ L + +I + L+ L Y HS Sbjct: 115 NTIQYRGCYLR--EHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHS 172 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV--DYQ 208 ++HRDVK N+++ + ++L D+G A PA N V + Y+ PE+++ D Sbjct: 173 HNMIHRDVKAGNILLS-EPGLVKLGDFGSASIMAPA---NSFVGTPYWMAPEVILAMDEG 228 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 YD +D+WSLG + R+ P F+ + L IA+ Sbjct: 229 QYDGKVDVWSLGITCIELAERKPPLFN-MNAMSALYHIAQ-------------------- 267 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 N + S + +D L+ Q R T++ ++H + Sbjct: 268 ---------------NESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRF 308 >5UUU-A nrPDB Length = 547 Score = 210 bits (536), Expect = 5e-55, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 130/313 (41%), Gaps = 57/313 (18%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREV-----KILENL- 89 +D+ + R +GRG + EV+ + +K L + K + E +I+ +L Sbjct: 196 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 255 Query: 90 --RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKA 144 I+ + P + + + +N D + ++ D+RFY E++ Sbjct: 256 STGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 313 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL 204 L++ H++ +++RD+KP N+++D + +R+ D GLA + ++ + V + + PE+L Sbjct: 314 LEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDF-SKKKPHASVGTHGYMAPEVL 371 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQD-NYDQLVRIAKVLGTEELYGYLKKYH 263 YD S D +SLGCML ++ PF + + ++ R+ + E Sbjct: 372 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE---------- 421 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL-----TAKE 318 SPE LL+ LL+ D +RL A+E Sbjct: 422 --------------------------LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQE 455 Query: 319 AMEHPYFYPVVKE 331 E P+F + + Sbjct: 456 VKESPFFRSLDWQ 468 >2GCD-A nrPDB Length = 309 Score = 210 bits (534), Expect = 9e-55, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 125/296 (42%), Gaps = 54/296 (18%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVKILENLRGGT 93 + +R++G G + V+ A ++ N+E V +K + K + I +EV+ L+ LR Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH-P 75 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNT--DFKQLYQI-LTDFDIRFYMYELLKALDYCHS 150 N I+ T LV EY + D ++++ L + +I + L+ L Y HS Sbjct: 76 NTIQYRGCYLR--EHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHS 133 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV--DYQ 208 ++HRDVK N+++ + ++L D+G A PA N V + Y+ PE+++ D Sbjct: 134 HNMIHRDVKAGNILLS-EPGLVKLGDFGSASIMAPA---NSFVGTPYWMAPEVILAMDEG 189 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 268 YD +D+WSLG + R+ P F+ + L IA+ Sbjct: 190 QYDGKVDVWSLGITCIELAERKPPLFN-MNAMSALYHIAQ-------------------- 228 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 N + S + +D L+ Q R T++ ++H + Sbjct: 229 ---------------NESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRF 269 >3PVW-A nrPDB Length = 695 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 130/313 (41%), Gaps = 57/313 (18%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREV-----KILENL- 89 +D+ + R +GRG + EV+ + +K L + K + E +I+ +L Sbjct: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 Query: 90 --RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKA 144 I+ + P + + + +N D + ++ D+RFY E++ Sbjct: 247 STGDCPFIVCMSYAFHTP--DKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL 204 L++ H++ +++RD+KP N+++D + +R+ D GLA + ++ + V + + PE+L Sbjct: 305 LEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDF-SKKKPHASVGTHGYMAPEVL 362 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQD-NYDQLVRIAKVLGTEELYGYLKKYH 263 YD S D +SLGCML ++ PF + + ++ R+ + E Sbjct: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVE---------- 412 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL-----TAKE 318 SPE LL+ LL+ D +RL A+E Sbjct: 413 --------------------------LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQE 446 Query: 319 AMEHPYFYPVVKE 331 E P+F + + Sbjct: 447 VKESPFFRSLDWQ 459 >4WUA-A nrPDB Length = 401 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 74/361 (20%), Positives = 142/361 (39%), Gaps = 77/361 (21%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILENLRGG-TN- 94 Y ++RKLG G +S V+ + +I + V +K++K + + E+++L+++R N Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPND 101 Query: 95 -----IIKLIDTVK--DPVSKTPALVFEYINNTDFKQL----YQILTDFDIRFYMYELLK 143 +++L+D K +VFE + + K + YQ L ++ + ++L+ Sbjct: 102 PNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQ 161 Query: 144 ALDYCHSK-GIMHRDVKPHNVMIDHQQK-------------------------------- 170 LDY H+K I+H D+KP N+++ ++ Sbjct: 162 GLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPATA 221 Query: 171 ----------------KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSL 214 K+++ D G A + H + + + +R ++ E+L+ Y+ Sbjct: 222 GNFLVNPLEPKNAEKLKVKIADLGNACWVH--KHFTEDIQTRQYRSLEVLIG-SGYNTPA 278 Query: 215 DMWSLGCMLASMIFRREPFFHGQ-----DNYDQLVRIAKVLG-TEELYGYLKKYHIDLDP 268 D+WS CM + F + D + I ++LG KY + Sbjct: 279 DIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFT 338 Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPE----ALDLLDKLLRYDHQQRLTAKEAMEHPY 324 D+ K W F ++ S E D L +L ++R TA E + HP+ Sbjct: 339 KKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPW 398 Query: 325 F 325 Sbjct: 399 L 399 >5KKR-C nrPDB Length = 395 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 65/309 (21%), Positives = 126/309 (40%), Gaps = 20/309 (6%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKI----LKPVKKKKIKREVKILENLRGGT 93 DD++ + +LG G VF+ + + + K+ +KP + +I RE+++L Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSP 126 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYC-H 149 I+ ++ E+++ Q+ + + + + ++K L Y Sbjct: 127 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 184 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 IMHRDVKP N++++ + +++L D+G++ + N V +R + PE L Sbjct: 185 KHKIMHRDVKPSNILVNSR-GEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGT-H 241 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG-TEELYGYLKKYHIDLDP 268 Y D+WS+G L M R P +L+ +V G E + L Sbjct: 242 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 301 Query: 269 HFNDILGQHSRKRWENFIHSENRHLV-----SPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 + D + ++I +E + S E D ++K L + +R K+ M H Sbjct: 302 YGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 361 Query: 324 YFYPVVKEQ 332 + E+ Sbjct: 362 FIKRSDAEE 370 >4KIK-B nrPDB Length = 677 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 62/297 (20%), Positives = 119/297 (40%), Gaps = 42/297 (14%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKI----LKPVKKKKIKREVKILENLRGGTNI 95 +++ +LG G + V N E++ +K L P +++ E++I+ L N+ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTH-PNV 79 Query: 96 IKLIDTVKDP----VSKTPALVFEYINNTDFKQLYQI------LTDFDIRFYMYELLKAL 145 + D + + P L EY D ++ L + I + ++ AL Sbjct: 80 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASAL 139 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKL--RLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 Y H I+HRD+KP N+++ +++L ++ID G A+ V + + PEL Sbjct: 140 RYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 199 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK-----VLGTEELYGY 258 L + Q Y ++D WS G + I PF ++ + ++ +E+L G Sbjct: 200 L-EQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGT 258 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT 315 +K P+ + + ++W L +L + +QR T Sbjct: 259 VKFSSSLPYPNNLNSVLAERLEKW-------------------LQLMLMWHPRQRGT 296 >3ALO-A nrPDB Length = 327 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 58/329 (17%), Positives = 129/329 (39%), Gaps = 60/329 (18%) Query: 18 SLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV--- 74 + ++WD+ A +D + + ++GRG Y V + ++ + + + VK ++ Sbjct: 10 KISPEQHWDFTA--------EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDE 61 Query: 75 -KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ------ 127 ++K++ ++ ++ I++ + + E ++ T F + Y+ Sbjct: 62 KEQKQLLMDLDVVMRSSDCPYIVQFYGALFR--EGDCWICMELMS-TSFDKFYKYVYSVL 118 Query: 128 --ILTDFDIRFYMYELLKALDYCHSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH 184 ++ + + +KAL++ I+HRD+KP N+++D ++L D+G++ Sbjct: 119 DDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS-GNIKLCDFGISGQLV 177 Query: 185 PAQEYNVRVASRYFKGPELL---VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYD 241 + R + PE + Q YD D+WSLG L + R P+ +D Sbjct: 178 DSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFD 237 Query: 242 QLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDL 301 QL ++ K + + + SP ++ Sbjct: 238 QLTQVVKGDPPQ--------------------------------LSNSEEREFSPSFINF 265 Query: 302 LDKLLRYDHQQRLTAKEAMEHPYFYPVVK 330 ++ L D +R KE ++HP+ + Sbjct: 266 VNLCLTKDESKRPKYKELLKHPFILMYEE 294 >2VD5-A nrPDB Length = 412 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 74/317 (23%), Positives = 119/317 (37%), Gaps = 59/317 (18%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI------LKPVKKKKIKREVKILENL 89 +DD+++++ +GRG +SEV + +KI LK + + E +L N Sbjct: 59 QRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN- 117 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD----IRFYMYELLKAL 145 I +L +D LV EY D L + RFY+ E++ A+ Sbjct: 118 GDRRWITQLHFAFQD--ENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAI 175 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN--VRVASRYFKGPEL 203 D H G +HRD+KP N+++D + +RL D+G V V + + PE+ Sbjct: 176 DSVHRLGYVHRDIKPDNILLD-RCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEI 234 Query: 204 LV------DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 L Y D W+LG M + + PF+ T E YG Sbjct: 235 LQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADS--------------TAETYG 280 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL--- 314 + Y E+ V EA D + +LL + RL Sbjct: 281 KIVHYK-------------------EHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRG 320 Query: 315 TAKEAMEHPYFYPVVKE 331 A + HP+F+ + + Sbjct: 321 GAGDFRTHPFFFGLDWD 337 >4APC-A nrPDB Length = 350 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 52/313 (16%), Positives = 127/313 (40%), Gaps = 53/313 (16%) Query: 34 WGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVK-----ILKPVKKKKIKREVKILEN 88 + + + Y ++K+G G + + + + + V+K + ++++ +REV +L N Sbjct: 20 FQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLAN 79 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLK 143 ++ NI++ ++ ++ + + +V +Y D + + + I + ++ Sbjct: 80 MKH-PNIVQYRESFEE--NGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICL 136 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY-NVRVASRYFKGPE 202 AL + H + I+HRD+K N+ + + ++L D+G+A + E + + Y+ PE Sbjct: 137 ALKHVHDRKILHRDIKSQNIFLT-KDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPE 195 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 + + + Y+ D+W+LGC+L + + F G L I+ L+ Sbjct: 196 -ICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHY----- 249 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 S + L+ +L + + + R + +E Sbjct: 250 --------------------------------SYDLRSLVSQLFKRNPRDRPSVNSILEK 277 Query: 323 PYFYPVVKEQSQP 335 + +++ P Sbjct: 278 GFIAKRIEKFLSP 290 >3EQC-A nrPDB Length = 360 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 65/309 (21%), Positives = 126/309 (40%), Gaps = 20/309 (6%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKI----LKPVKKKKIKREVKILENLRGGT 93 DD++ + +LG G VF+ + + + K+ +KP + +I RE+++L Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSP 91 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYC-H 149 I+ ++ E+++ Q+ + + + + ++K L Y Sbjct: 92 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 149 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 IMHRDVKP N++++ + +++L D+G++ + N V +R + PE L Sbjct: 150 KHKIMHRDVKPSNILVNSR-GEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGT-H 206 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG-TEELYGYLKKYHIDLDP 268 Y D+WS+G L M R P +L+ +V G E + L+ Sbjct: 207 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLNK 266 Query: 269 HFNDILGQHSRKRWENFIHSENRHLV-----SPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 D + ++I +E + S E D ++K L + +R K+ M H Sbjct: 267 FGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 326 Query: 324 YFYPVVKEQ 332 + E+ Sbjct: 327 FIKRSDAEE 335 >4F9B-A nrPDB Length = 361 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 90/349 (25%), Positives = 148/349 (42%), Gaps = 56/349 (16%) Query: 31 VPSWGNQDDYQLVRKLGRGKYSEVFEAI---NITNNERVVVKILKPVKKK-KIKREVKIL 86 VP N +++ K+G G +S V+ A + E++ +K L P +I E++ L Sbjct: 16 VPQLSNV--FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCL 73 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALD 146 G N++ + + + + Y+ + F + L+ ++R YM L KAL Sbjct: 74 TVAGGQDNVMGVKYCFRK--NDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALK 131 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA-------------------- 186 H GI+HRDVKP N + + + KK L+D+GLA+ H Sbjct: 132 RIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQN 191 Query: 187 ---------QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQ 237 Q+ R + F+ PE+L ++DMWS G + S++ R PF+ Sbjct: 192 KCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKAS 251 Query: 238 DNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENF------------ 285 D+ L +I + G+ E K + + ++ Q RK E Sbjct: 252 DDLTALAQIMTIRGSRETIQAAKTFGKSILCS-KEVPAQDLRKLCERLRGMDSSTPKLTS 310 Query: 286 ------IHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPV 328 + E + V EA DLLDKLL + R+TA+EA+ HP+F + Sbjct: 311 DIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDM 359 >4PWN-A nrPDB Length = 274 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 56/295 (18%), Positives = 116/295 (39%), Gaps = 50/295 (16%) Query: 45 KLGRGKYSEVFEAINITNNERVVV-----KILKPVKKKKIKREVKILENLRGGTNIIKLI 99 ++GRG + V++ ++ V + L ++++ K E ++L+ L+ NI++ Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQH-PNIVRFY 75 Query: 100 DTVKDPVS--KTPALVFEYINNTDFKQLYQILTDFDI---RFYMYELLKALDYCHSK--G 152 D+ + V K LV E + + K + I R + ++LK L + H++ Sbjct: 76 DSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDY 212 I+HRD+K N+ I +++ D GLA A + + F PE+ + YD Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYEE--KYDE 193 Query: 213 SLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFND 272 S+D+++ G + M P+ Q+ R+ Sbjct: 194 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVT------------------------- 228 Query: 273 ILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 + + PE ++++ +R + +R + K+ + H +F Sbjct: 229 ----------SGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >3QA8-A nrPDB Length = 676 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 58/268 (21%), Positives = 114/268 (42%), Gaps = 23/268 (8%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKI----LKPVKKKKIKREVKILENLRGGTNI 95 +++ +LG G + V I+ E+V +K L P +++ E++I++ L N+ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKL-NHPNV 74 Query: 96 IKLIDT----VKDPVSKTPALVFEYINNTDFKQLYQI------LTDFDIRFYMYELLKAL 145 + + K + P L EY D ++ L + IR + ++ AL Sbjct: 75 VSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSAL 134 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKL--RLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 Y H I+HRD+KP N+++ ++L ++ID G A+ + V + + PEL Sbjct: 135 RYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPEL 194 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK-----VLGTEELYGY 258 L + + Y ++D WS G + I PF ++ + ++ ++L G Sbjct: 195 L-EQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEHIVVYDDLTGA 253 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFI 286 +K + P+ + +RW + Sbjct: 254 VKFSSVLPTPNHLSGILAGKLERWLQCM 281 >4OTD-A nrPDB Length = 341 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 60/310 (19%), Positives = 116/310 (37%), Gaps = 58/310 (18%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP------VKKKKIKREVKILENL-- 89 +D++ + LGRG + +V + + E +K LK + + + E +IL + Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 90 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDY 147 G ++ L + P + V EY D + ++ FY ++ L + Sbjct: 72 AGHPFLVNLFGCFQTP--EHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQF 129 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFKGPELLVD 206 H I++RD+K ++ + +++ D+GL + + + F PE+L D Sbjct: 130 LHEHKIVYRDLKLD-NLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 188 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 Y ++D W LG +L M+ PF G D + I Sbjct: 189 TS-YTRAVDWWGLGVLLYEMLVGESPF-PGDDEEEVFDSIVN------------------ 228 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-----AKEAME 321 +S EA+ ++ +LLR + ++RL A++ + Sbjct: 229 -------------------DEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKK 269 Query: 322 HPYFYPVVKE 331 P+F + E Sbjct: 270 QPFFRTLGWE 279 >2XNP-A nrPDB Length = 279 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 70/308 (22%), Positives = 125/308 (40%), Gaps = 58/308 (18%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-----PVKKKKIKREVKILENLRGG 92 +DY+++ +G G Y + ++ + +V K L +K+ + EV +L L+ Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH- 64 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-------QILTDFDIRFYMYELLKAL 145 NI++ D + D + T +V EY D + Q L + + M +L AL Sbjct: 65 PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLAL 124 Query: 146 DYCHSKG-----IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY-HPAQEYNVRVASRYFK 199 CH + ++HRD+KP NV +D +Q ++L D+GLA H V + Y+ Sbjct: 125 KECHRRSDGGHTVLHRDLKPANVFLDGKQ-NVKLGDFGLARILNHDTSFAKTFVGTPYYM 183 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE ++ Y+ D+WSLGC+L + PF +EL G + Sbjct: 184 SPE-QMNRMSYNEKSDIWSLGCLLYELCALMPPF--------------TAFSQKELAGKI 228 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 ++ P+ S E +++ ++L R + +E Sbjct: 229 REGKFRRIPY-----------------------RYSDELNEIITRMLNLKDYHRPSVEEI 265 Query: 320 MEHPYFYP 327 +E+P Sbjct: 266 LENPLILE 273 >2WQN-A nrPDB Length = 310 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 65/310 (20%), Positives = 124/310 (40%), Gaps = 55/310 (17%) Query: 23 EYWDYEAHVPSWG--NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI------LKPV 74 ++ +A P G ++++ +K+GRG++SEV+ A + + V +K + Sbjct: 15 QFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAK 74 Query: 75 KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL----- 129 + +E+ +L+ L N+IK + + +V E + D ++ + Sbjct: 75 ARADCIKEIDLLKQL-NHPNVIKYYASFIE--DNELNIVLELADAGDLSRMIKHFKKQKR 131 Query: 130 --TDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP-A 186 + + Y +L AL++ HS+ +MHRD+KP NV I ++L D GL F+ Sbjct: 132 LIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITAT-GVVKLGDLGLGRFFSSKT 190 Query: 187 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRI 246 + V + Y+ PE + + Y++ D+WSLGC+L M + PF+ + N L + Sbjct: 191 TAAHSLVGTPYYMSPERIHE-NGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKK 249 Query: 247 AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLL 306 + L S E L++ + Sbjct: 250 IEQCDYPPLPS----------------------------------DHYSEELRQLVNMCI 275 Query: 307 RYDHQQRLTA 316 D ++R Sbjct: 276 NPDPEKRPDV 285 >5O2B-A nrPDB Length = 285 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 54/295 (18%), Positives = 124/295 (42%), Gaps = 51/295 (17%) Query: 45 KLGRGKYSEVFEAINITNNERVVV-----KILKPVKKKKIKREVKILENLRGGTNIIKLI 99 +LGRG + V++ ++ V + L ++++ K E ++L+ L+ NI++ Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH-PNIVRFY 81 Query: 100 DTVKD--PVSKTPALVFEYINNTDFK---QLYQILTDFDIRFYMYELLKALDYCHSK--G 152 D+ + K LV E + + K + ++++ +R + ++LK L + H++ Sbjct: 82 DSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 141 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDY 212 I+HRD+K N+ I +++ D GLA + +V + + F PE+ ++ YD Sbjct: 142 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSV-IGTPEFMAPEMYEEH--YDE 198 Query: 213 SLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFND 272 S+D+++ G + M P+ Q+ ++ + Sbjct: 199 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIK--------------------- 237 Query: 273 ILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 + + PE ++++ +R + +RL+ ++ + H +F Sbjct: 238 --------------PASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >3C51-A nrPDB Length = 543 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 71/330 (21%), Positives = 121/330 (36%), Gaps = 58/330 (17%) Query: 24 YWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK------K 77 + ++ +D + R LGRG + EVF + K L + + Sbjct: 171 FLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQ 230 Query: 78 KIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-------QILT 130 E KIL + I+ L + LV +N D + Sbjct: 231 GAMVEKKILAKV-HSRFIVSLAYAFETKTD--LCLVMTIMNGGDIRYHIYNVDEDNPGFQ 287 Query: 131 DFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EY 189 + FY +++ L++ H + I++RD+KP NV++D +R+ D GLA Q + Sbjct: 288 EPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLD-DDGNVRISDLGLAVELKAGQTKT 346 Query: 190 NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKV 249 + F PELL+ + YD+S+D ++LG L MI R PF + + Sbjct: 347 KGYAGTPGFMAPELLLGEE-YDFSVDYFALGVTLYEMIAARGPFRARGEKVE-------- 397 Query: 250 LGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYD 309 +EL + + + F SP + D + LL+ D Sbjct: 398 --NKELKQRVLEQAVTYPDKF------------------------SPASKDFCEALLQKD 431 Query: 310 HQQRL-----TAKEAMEHPYFYPVVKEQSQ 334 ++RL + HP F + Q + Sbjct: 432 PEKRLGFRDGSCDGLRTHPLFRDISWRQLE 461 >5O2C-A nrPDB Length = 380 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 54/295 (18%), Positives = 124/295 (42%), Gaps = 51/295 (17%) Query: 45 KLGRGKYSEVFEAINITNNERVVV-----KILKPVKKKKIKREVKILENLRGGTNIIKLI 99 +LGRG + V++ ++ V + L ++++ K E ++L+ L+ NI++ Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH-PNIVRFY 90 Query: 100 DTVKD--PVSKTPALVFEYINNTDFK---QLYQILTDFDIRFYMYELLKALDYCHSK--G 152 D+ + K LV E + + K + ++++ +R + ++LK L + H++ Sbjct: 91 DSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 150 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDY 212 I+HRD+K N+ I +++ D GLA + +V + + F PE+ ++ YD Sbjct: 151 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSV-IGTPEFMAPEMYEEH--YDE 207 Query: 213 SLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFND 272 S+D+++ G + M P+ Q+ ++ + Sbjct: 208 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIK--------------------- 246 Query: 273 ILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 327 + + PE ++++ +R + +RL+ ++ + H +F Sbjct: 247 --------------PASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 >2WTK-C nrPDB Length = 305 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 71/321 (22%), Positives = 125/321 (38%), Gaps = 55/321 (17%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-------PVKKKKIKREVKILENLRG 91 Y + LG G Y +V E ++ R VKILK P + +K+E+++L LR Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL----YQILTDFDIRFYMYELLKALDY 147 N+I+L+D + + + +V EY + L + Y +L+ L+Y Sbjct: 66 -KNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEY 124 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP---AQEYNVRVASRYFKGPELL 204 HS+GI+H+D+KP N+++ L++ G+AE HP S F+ PE+ Sbjct: 125 LHSQGIVHKDIKPGNLLLTT-GGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIA 183 Query: 205 VDYQMY-DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 + + +D+WS G L ++ PF G + Y +L+ + K Sbjct: 184 NGLDTFSGFKVDIWSAGVTLYNITTGLYPF-EGDNIY-------------KLFENIGKGS 229 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 + L DLL +L Y+ +R + ++ +H Sbjct: 230 YAIPGDCGPPLS------------------------DLLKGMLEYEPAKRFSIRQIRQHS 265 Query: 324 YFYPVVKEQSQPCADNAVLSS 344 +F P + Sbjct: 266 WFRKKHPPAEAPVPIPPSPDT 286 >3VN9-A nrPDB Length = 340 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 59/304 (19%), Positives = 124/304 (40%), Gaps = 54/304 (17%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK----PVKKKKIKREVKILENLRGGT 93 DD + + +LGRG Y V + ++ + + + VK ++ ++K++ ++ I Sbjct: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-------QILTDFDIRFYMYELLKALD 146 + + + E ++ T + Y Q + + + ++KAL+ Sbjct: 111 FTVTFYGALFREGD--VWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 Query: 147 YCHSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL- 204 + HSK ++HRDVKP NV+I+ ++++ D+G++ + + + + + PE + Sbjct: 168 HLHSKLSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 Query: 205 --VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 ++ + Y D+WSLG + + R P+ + QL ++ EE L Sbjct: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV-----VEEPSPQLPA- 280 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 S E +D + L+ + ++R T E M+H Sbjct: 281 -----------------------------DKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 Query: 323 PYFY 326 P+F Sbjct: 312 PFFT 315 >6BXI-A nrPDB Length = 333 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 68/343 (19%), Positives = 128/343 (37%), Gaps = 90/343 (26%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKK---IKREVKILENLRG 91 +D++ ++ +GRG + EV +KIL+ ++K++ I+ E IL Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 65 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYC 148 ++K+ + +D ++ L+ E++ D L LT+ + +FY+ E + A+D Sbjct: 66 L-WVVKMFYSFQDKLN--LYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSI 122 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN------------------ 190 H G +HRD+KP N+++D + ++L D+GL A Sbjct: 123 HQLGFIHRDIKPDNLLLDSK-GHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNM 181 Query: 191 ------------------VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREP 232 V + + PE+ + Y+ D WSLG ++ M+ P Sbjct: 182 NSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQT-GYNKLCDWWSLGVIMYEMLIGYPP 240 Query: 233 FFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRH 292 F +E KK W+ + Sbjct: 241 F-----------------CSETPQETYKKVM-----------------NWKETLTFPPEV 266 Query: 293 LVSPEALDLLDK-LLRYDHQQRLTA---KEAMEHPYFYPVVKE 331 +S +A DL+ + ++H R+ A +E + +F V E Sbjct: 267 PISEKAKDLILRFCCEWEH--RIGAPGVEEIKSNSFFEGVDWE 307 >4CRS-A nrPDB Length = 341 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 60/312 (19%), Positives = 110/312 (35%), Gaps = 58/312 (18%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP------VKKKKIKREVKILENL 89 N D++ L RG + +V A NE +K LK + + E +I E + Sbjct: 10 NLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV 69 Query: 90 RG--GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKAL 145 ++ L + + V EY D + ++ FY ++ L Sbjct: 70 NSVRHPFLVNLFACFQ--TKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGL 127 Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFKGPELL 204 Y H I++RD+K ++ + +++ D+GL + + + F PE+L Sbjct: 128 QYLHEHKIVYRDLKLD-NLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 186 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 + Y ++D W LG ++ M+ PF G D + I Sbjct: 187 TETS-YTRAVDWWGLGVLIYEMLVGESPF-PGDDEEEVFDSIVN---------------- 228 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE-----A 319 +S EA+ ++ +LLR + ++RL A E Sbjct: 229 ---------------------DEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDV 267 Query: 320 MEHPYFYPVVKE 331 +HP+F + Sbjct: 268 KKHPFFRLIDWS 279 >4CSV-A nrPDB Length = 275 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 49/296 (16%), Positives = 109/296 (36%), Gaps = 52/296 (17%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGT 93 + + L RKLG G++ EV+E N V VK LK + ++ +E +I++ L+ Sbjct: 9 PRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKKLKH-P 67 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-----QILTDFDIRFYMYELLKALDYC 148 N+++L ++ EY+++ + + ++ + Y Sbjct: 68 NLVQLYGVC--TKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYL 125 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLV 205 S+ +HRD+ N ++ + +++ D+GLA + EY R +++ + PE + Sbjct: 126 ESQNFIHRDLAARNCLVG-ENNVVKVADFGLARLINED-EYTARAGAKFPIKWTAPEAI- 182 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 Y + D+W+ G +L + + + G + + ++ + G Sbjct: 183 SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQG-------- 234 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 E +L+ + ++R T E + Sbjct: 235 ----------------------------CPEEIYELMLQCWNKSPEERPTFAETLH 262 >4OLI-A nrPDB Length = 645 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 64/320 (20%), Positives = 124/320 (38%), Gaps = 41/320 (12%) Query: 26 DYEAHVPSWGNQDDYQLVRKLGRGKYSEV----FEAINITNNERVVVKILK----PVKKK 77 D A P+ ++ + +R LG G + +V ++ N E V VK LK P + Sbjct: 341 DSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRS 400 Query: 78 KIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--QILTDFDIR 135 K+E+ IL L +IIK +D K+ LV EY+ + + + Sbjct: 401 GWKQEIDILRTLYH-EHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLL 459 Query: 136 FYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV-- 193 + ++ + + Y HS+ +HR++ NV++D+ + +++ D+GLA+ EY Sbjct: 460 LFAQQICEGMAYLHSQHYIHRNLAARNVLLDN-DRLVKIGDFGLAKAVPEGHEYYRVRED 518 Query: 194 --ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG 251 + ++ PE L +Y+ Y Y+ D+WS G L ++ H + + +++G Sbjct: 519 GDSPVFWYAPECLKEYKFY-YASDVWSFGVTLYELLT------HCDSSQSPPTKFLELIG 571 Query: 252 TEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQ 311 + + + E E L+ + Sbjct: 572 IAQ----------------GQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEAS 615 Query: 312 QRLTAKEAMEHPYFYPVVKE 331 R T + + P V ++ Sbjct: 616 FRPTFENLI--PILKTVHEK 633 Score = 82.7 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 41/278 (14%), Positives = 78/278 (28%), Gaps = 56/278 (20%) Query: 57 AINITNNERVVVKILKPVKKKKIKR--EVKILENLRGGTNIIKLIDTVKDPVSKTPALVF 114 + RVV+K+L P E L + T++ + +V Sbjct: 88 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENI--MVT 145 Query: 115 EYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDH--- 167 EY+ + + + +L AL Y +K ++H +V N+++ Sbjct: 146 EYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGL 205 Query: 168 ---QQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY-QMYDYSLDMWSLGCML 223 ++L D G+ +E R+ + PE L ++D W G L Sbjct: 206 AEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATL 262 Query: 224 ASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWE 283 + F E + + HF + Sbjct: 263 LEICFDGEAPLQSRSPSE-------------------------KEHFYQRQHRLPEPSCP 297 Query: 284 NFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 L + L Y+ QR + + + Sbjct: 298 QLAT-------------LTSQCLTYEPTQRPSFRTILR 322 >3FME-A nrPDB Length = 290 Score = 200 bits (508), Expect = 9e-52, Method: Composition-based stats. Identities = 59/304 (19%), Positives = 124/304 (40%), Gaps = 54/304 (17%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK----PVKKKKIKREVKILENLRGGT 93 DD + + +LGRG Y V + ++ + + + VK ++ ++K++ ++ I Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 66 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-------QILTDFDIRFYMYELLKALD 146 + + + E ++ T + Y Q + + + ++KAL+ Sbjct: 67 FTVTFYGALFR--EGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 123 Query: 147 YCHSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL- 204 + HSK ++HRDVKP NV+I+ ++++ D+G++ + ++ + + PE + Sbjct: 124 HLHSKLSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERIN 182 Query: 205 --VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 ++ + Y D+WSLG + + R P+ + QL ++ EE L Sbjct: 183 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV-----VEEPSPQLPA- 236 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 S E +D + L+ + ++R T E M+H Sbjct: 237 -----------------------------DKFSAEFVDFTSQCLKKNSKERPTYPELMQH 267 Query: 323 PYFY 326 P+F Sbjct: 268 PFFT 271 >6GQK-A nrPDB Length = 328 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 64/340 (18%), Positives = 118/340 (34%), Gaps = 78/340 (22%) Query: 13 YAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEA-----INITNNERVV 67 Y + L W++ ++ + LG G + +V EA I V Sbjct: 24 YIDPTQLPYDHKWEF--------PRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVA 75 Query: 68 VKILKP----VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFK 123 VK+LKP +++ + E+K+L L NI+ L+ ++ EY D Sbjct: 76 VKMLKPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTH--GGPTLVITEYCCYGDLL 133 Query: 124 QLYQ-------------------ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVM 164 + LT + + Y++ K + + SK +HRD+ N++ Sbjct: 134 NFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNIL 193 Query: 165 IDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGC 221 + H ++ D+GLA Y + +R + PE + + +Y + D+WS G Sbjct: 194 LTHGNIT-KICDFGLARDIKNDSNYVDKGNARLPVKWMAPESIFN-SVYTFESDVWSYGI 251 Query: 222 MLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKR 281 L + F G Y + +K Y +K+ P + Sbjct: 252 FLWEL------FSLGSSPYPGMPVDSK------FYKMIKEGFRMSSPEY----------- 288 Query: 282 WENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 E D++ D +R T K+ ++ Sbjct: 289 ------------APAEMYDIMKTCWDADPDKRPTFKQIVQ 316 >4YHJ-A nrPDB Length = 584 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 65/323 (20%), Positives = 119/323 (36%), Gaps = 55/323 (17%) Query: 22 REYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK------ 75 ++ ++ ++ ++ R LG+G + EV + K L+ + Sbjct: 169 SQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKG 228 Query: 76 KKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-----QILT 130 + E +ILE ++ ++ L + LV +N D K Sbjct: 229 EAMALNEKRILEKVQS-RFVVSLAYAYE--TKDALCLVLTIMNGGDLKFHIYNLGNPGFD 285 Query: 131 DFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN 190 + FY EL L+ + I++RD+KP N+++D + +R+ D GLA Q Sbjct: 286 EQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLD-DRGHIRISDLGLATEIPEGQRVR 344 Query: 191 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVL 250 RV + + PE++ + + Y +S D W LGC++ MI PF + + + Sbjct: 345 GRVGTVGYMAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPF----------KKYKEKV 393 Query: 251 GTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDH 310 EE+ +K + F S +A + LL + Sbjct: 394 KWEEVDQRIKNDTEEYSEKF------------------------SEDAKSICRMLLTKNP 429 Query: 311 QQRL-----TAKEAMEHPYFYPV 328 +RL A +HP F + Sbjct: 430 SKRLGCRGEGAAGVKQHPVFKDI 452 >5O0Y-A nrPDB Length = 579 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 63/315 (20%), Positives = 125/315 (39%), Gaps = 62/315 (19%) Query: 51 YSEVFEAINITNNERVVVKIL----------KPVKKKKIKREVKILENLRGGTNIIKLID 100 +SEV++A ++T V VKI K K RE +I + L I+KL D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL-DHPRIVKLYD 355 Query: 101 TVKDPVSKTPALVFEYINNTDFK---QLYQILTDFDIRFYMYELLKALDYCHSKG--IMH 155 + + V EY D + ++++++ + R + +++ AL Y + I+H Sbjct: 356 YF-SLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIH 414 Query: 156 RDVKPHNVMI--DHQQKKLRLIDWGLAEFYHPAQEYNVRV--------ASRYFKGPELLV 205 D+KP N+++ ++++ D+GL++ +V + ++ PE V Sbjct: 415 YDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFV 474 Query: 206 ---DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 + +D+WS+G + ++ R+PF H Q D L + TE + Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPP---- 530 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 + +V+PEA + + L Y + R+ ++ Sbjct: 531 ----------------------------KPVVTPEAKAFIRRCLAYRKEDRIDVQQLACD 562 Query: 323 PYFYPVVKEQSQPCA 337 PY P +++ + Sbjct: 563 PYLLPHIRKSVSTSS 577 >6DBM-A nrPDB Length = 318 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 60/270 (22%), Positives = 117/270 (43%), Gaps = 19/270 (7%) Query: 31 VPSWGNQDDYQLVRKLGRGKYSEV----FEAINITNNERVVVKILK----PVKKKKIKRE 82 P+ ++ + +R LG G + +V ++ N E V VK LK P + K+E Sbjct: 24 DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQE 83 Query: 83 VKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--QILTDFDIRFYMYE 140 + IL L +IIK +D + + LV EY+ + + + + + Sbjct: 84 IDILRTLYH-EHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQ 142 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV----ASR 196 + + + Y HS+ +HRD+ NV++D+ + +++ D+GLA+ EY + Sbjct: 143 ICEGMAYLHSQHYIHRDLAARNVLLDN-DRLVKIGDFGLAKAVPEGHEYYRVREDGDSPV 201 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK-VLGTEEL 255 ++ PE L +Y+ Y Y+ D+WS G L ++ + + +L+ IA+ + L Sbjct: 202 FWYAPECLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRL 260 Query: 256 YGYLKKY-HIDLDPHFNDILGQHSRKRWEN 284 L++ + + + WE Sbjct: 261 TELLERGERLPRPDKCPAEVYHLMKNCWET 290 >1ZXE-A nrPDB Length = 303 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 64/326 (19%), Positives = 129/326 (39%), Gaps = 70/326 (21%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRGGTNII 96 D++ + LG+G + +V +A N ++ +K ++ ++K I EV +L +L ++ Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQY-VV 65 Query: 97 KLIDTVKD-----------PVSKTPALVFEYINNTDFKQLYQILTDFDIR----FYMYEL 141 + + T + EY N L R ++ Sbjct: 66 RYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQI 125 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH---------------PA 186 L+AL Y HS+GI+HR++KP N+ ID + + +++ D+GLA+ H + Sbjct: 126 LEALSYIHSQGIIHRNLKPMNIFID-ESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSS 184 Query: 187 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRI 246 + + + E+L Y+ +DM+SLG + MI+ PF G + + L + Sbjct: 185 DNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGMERVNILKK- 240 Query: 247 AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLL 306 L+ I+ P F+D + +K ++ L+ Sbjct: 241 ------------LRSVSIEFPPDFDDNKMKVEKK--------------------IIRLLI 268 Query: 307 RYDHQQRLTAKEAMEHPYFYPVVKEQ 332 +D +R A+ + + +++ Sbjct: 269 DHDPNKRPGARTLLNSGWLPVKHQDE 294 >1S9I-A nrPDB Length = 354 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 60/313 (19%), Positives = 119/313 (38%), Gaps = 24/313 (7%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKI----LKPVKKKKIKREVKILENLRGGT 93 DD++ + +LG G V + + + + K+ +KP + +I RE+++L Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSP 74 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHS 150 I+ ++ E+++ Q+ + + + + +L+ L Y Sbjct: 75 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLRE 132 Query: 151 KG-IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 K IMHRDVKP N++++ + +++L D+G++ + N V +R + PE L Sbjct: 133 KHQIMHRDVKPSNILVNSR-GEIKLCDFGVSGQLIDSMA-NSFVGTRSYMAPERLQGT-H 189 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 Y D+WS+G L + R P + + V+ EE + Sbjct: 190 YSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGR 249 Query: 270 FNDILGQHSRKRWENF----------IHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 G SR F + +P+ + ++K L + +R K Sbjct: 250 PVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKML 309 Query: 320 MEHPYFYPVVKEQ 332 H + E+ Sbjct: 310 TNHTFIKRSEVEE 322 >2OGV-A nrPDB Length = 317 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 57/312 (18%), Positives = 118/312 (37%), Gaps = 43/312 (13%) Query: 12 VYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-----RV 66 + + L E W++ +++ Q + LG G + +V EA + +V Sbjct: 20 TFIDPTQLPYNEKWEF--------PRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKV 71 Query: 67 VVKILKPV----KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDF 122 VK+LK +K+ + E+KI+ +L NI+ L+ ++ EY D Sbjct: 72 AVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH--GGPVLVITEYCCYGDL 129 Query: 123 KQLYQ-------------ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ 169 + L D+ + ++ + + + SK +HRDV NV++ + Sbjct: 130 LNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN-G 188 Query: 170 KKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASM 226 ++ D+GLA Y V+ +R + PE + D +Y D+WS G +L + Sbjct: 189 HVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDC-VYTVQSDVWSYGILLWEI 247 Query: 227 IFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFI 286 F G + Y ++ +K + + + ++ + + + Sbjct: 248 ------FSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPT 301 Query: 287 HSENRHLVSPEA 298 + + +A Sbjct: 302 FQQICSFLQEQA 313 >3BEA-A nrPDB Length = 333 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 57/316 (18%), Positives = 119/316 (37%), Gaps = 47/316 (14%) Query: 12 VYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-----RV 66 + + L E W++ +++ Q + LG G + +V EA + +V Sbjct: 28 TFIDPTQLPYNEKWEF--------PRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKV 79 Query: 67 VVKILKPV----KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDF 122 VK+LK +K+ + E+KI+ +L NI+ L+ ++ EY D Sbjct: 80 AVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH--GGPVLVITEYCCYGDL 137 Query: 123 KQLYQ-----------------ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMI 165 + L+ D+ + ++ + + + SK +HRDV NV++ Sbjct: 138 LNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL 197 Query: 166 DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCM 222 + ++ D+GLA Y V+ +R + PE + D +Y D+WS G + Sbjct: 198 TN-GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDC-VYTVQSDVWSYGIL 255 Query: 223 LASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRW 282 L + F G + Y ++ +K + + + ++ + + + Sbjct: 256 LWEI------FSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPT 309 Query: 283 ENFIHSENRHLVSPEA 298 + + +A Sbjct: 310 HRPTFQQICSFLQEQA 325 >4IAN-A nrPDB Length = 358 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 74/326 (22%), Positives = 141/326 (43%), Gaps = 43/326 (13%) Query: 39 DYQLVRKLGRGKYSEVFEAINI-TNNERVVVKILKPVK--KKKIKREVKILENLRGGT-- 93 Y + G+G +S V A + N+ V VKI++ + +K +E++ L+ L Sbjct: 31 RYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPD 90 Query: 94 ---NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI------LTDFDIRFYMYELLKA 144 + ++L + LVFE ++ + +++ + L +R Y +L A Sbjct: 91 DKFHCLRLFRHFYH--KQHLCLVFEPLS-MNLREVLKKYGKDVGLHIKAVRSYSQQLFLA 147 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL 204 L I+H D+KP N++++ + L+L D+G A + + SR+++ PE++ Sbjct: 148 LKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVAD-NDITPYLVSRFYRAPEII 206 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE----LYGYLK 260 + + YDY +DMWS+GC L + + F G+ N L + G G K Sbjct: 207 IG-KSYDYGIDMWSVGCTLYELYTGKI-LFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFK 264 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHS-------------------ENRHLVSPEALDL 301 H D + +F I +R + + S E++ + DL Sbjct: 265 DQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDL 324 Query: 302 LDKLLRYDHQQRLTAKEAMEHPYFYP 327 LD++L D +R++ +A++H + Sbjct: 325 LDQILMLDPAKRISINQALQHAFIQE 350 >3TT0-A nrPDB Length = 382 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 66/306 (21%), Positives = 118/306 (38%), Gaps = 52/306 (16%) Query: 30 HVPSWG-NQDDYQLVRKLGRGKYSEVFEA------INITNN-ERVVVKILKPVKKKK--- 78 P W +D L + LG G + +V A + N +V VK+LK +K Sbjct: 60 EDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLS 119 Query: 79 -IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI--------- 128 + E+++++ + NII L+ ++ EY + + ++ Q Sbjct: 120 DLISEMEMMKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYS 177 Query: 129 ----------LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG 178 L+ D+ Y++ + ++Y SK +HRD+ NV++ + +++ D+G Sbjct: 178 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFG 236 Query: 179 LAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFH 235 LA H Y R + PE L D ++Y + D+WS G +L + + Sbjct: 237 LARDIHHIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYP 295 Query: 236 GQDNYDQLVRIAKVLGTEELYGYLKKYH-IDLDPHFNDILGQHSRKRWENFIHSENRHLV 294 G + EEL+ LK+ H +D + + L R W Sbjct: 296 G-------------VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 342 Query: 295 SPEALD 300 E LD Sbjct: 343 LVEDLD 348 >4AN9-A nrPDB Length = 301 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 59/303 (19%), Positives = 114/303 (37%), Gaps = 50/303 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKI----LKPVKKKKIKREVKILENLRGGT 93 DD++ + +LG G VF+ + + + K+ +KP + +I RE+++L Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSP 67 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYC-H 149 I+ ++ E+++ Q+ + + + + ++K L Y Sbjct: 68 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 125 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 IMHRDVKP N++++ + +++L D+G++ + N V +R + PE L Sbjct: 126 KHKIMHRDVKPSNILVNSR-GEIKLCDFGVSGQL-IDEMANEFVGTRSYMSPERLQGT-H 182 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 Y D+WS+G L M R P ++ L + P Sbjct: 183 YSVQSDIWSMGLSLVEMAVGRYP-----------------RPPMAIFELLDYIVNEPPPK 225 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVV 329 + S E D ++K L + +R K+ M H + Sbjct: 226 LPSAV-------------------FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSD 266 Query: 330 KEQ 332 E+ Sbjct: 267 AEE 269 >3KRL-A nrPDB Length = 335 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 57/318 (17%), Positives = 119/318 (37%), Gaps = 49/318 (15%) Query: 12 VYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-----RV 66 + + L E W++ +++ Q + LG G + +V EA + +V Sbjct: 28 TFIDPTQLPYNEKWEF--------PRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKV 79 Query: 67 VVKILKPV----KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDF 122 VK+LK +K+ + E+KI+ +L NI+ L+ ++ EY D Sbjct: 80 AVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH--GGPVLVITEYCCYGDL 137 Query: 123 KQLYQI-------------------LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNV 163 + L+ D+ + ++ + + + SK +HRDV NV Sbjct: 138 LNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNV 197 Query: 164 MIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLG 220 ++ + ++ D+GLA Y V+ +R + PE + D +Y D+WS G Sbjct: 198 LLTN-GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDC-VYTVQSDVWSYG 255 Query: 221 CMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK 280 +L + F G + Y ++ +K + + + ++ + + + Sbjct: 256 ILLWEI------FSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALE 309 Query: 281 RWENFIHSENRHLVSPEA 298 + + +A Sbjct: 310 PTHRPTFQQICSFLQEQA 327 >4E20-A nrPDB Length = 290 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 50/212 (23%), Positives = 98/212 (46%), Gaps = 17/212 (8%) Query: 31 VPSWGNQDDYQLVRKLGRGKYSEV----FEAINITNNERVVVKILK----PVKKKKIKRE 82 P+ ++ + +R LG G + +V ++ N E V VK LK P + +RE Sbjct: 1 DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQRE 60 Query: 83 VKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--QILTDFDIRFYMYE 140 ++IL L +I+K +D K+ LV EY+ + + + + + Sbjct: 61 IEILRTLYH-EHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQ 119 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV----ASR 196 + + + Y H++ +HR + NV++D+ + +++ D+GLA+ EY + Sbjct: 120 ICEGMAYLHAQHYIHRALAARNVLLDN-DRLVKIGDFGLAKAVPEGHEYYRVREDGDSPV 178 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 228 ++ PE L + + Y Y+ D+WS G L ++ Sbjct: 179 FWYAPECLKECKFY-YASDVWSFGVTLYELLT 209 >3G0E-A nrPDB Length = 336 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 67/343 (19%), Positives = 121/343 (35%), Gaps = 80/343 (23%) Query: 12 VYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEA-----INITNNERV 66 VY + L W++ ++ + LG G + +V EA I V Sbjct: 28 VYIDPTQLPYDHKWEF--------PRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTV 79 Query: 67 VVKILKP----VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDF 122 VK+LKP +++ + E+K+L L NI+ L+ + ++ EY D Sbjct: 80 AVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC--TIGGPTLVITEYCCYGDL 137 Query: 123 KQLYQILTDFDI---------------------RFYMYELLKALDYCHSKGIMHRDVKPH 161 + D I + Y++ K + + SK +HRD+ Sbjct: 138 LNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAAR 197 Query: 162 NVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWS 218 N+++ H + ++ D+GLA Y V+ +R + PE + + +Y + D+WS Sbjct: 198 NILLTHGRIT-KICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNC-VYTFESDVWS 255 Query: 219 LGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHS 278 G L + F G Y + +K Y +K+ L P Sbjct: 256 YGIFLWEL------FSLGSSPYPGMPVDSK------FYKMIKEGFRMLSPEH-------- 295 Query: 279 RKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 E D++ D +R T K+ ++ Sbjct: 296 ---------------APAEMYDIMKTCWDADPLKRPTFKQIVQ 323 >6GVJ-A nrPDB Length = 429 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 124/309 (40%), Gaps = 63/309 (20%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKI--LKPVKKKKI---KREVKILENLR-GGT 93 Y +++++G G S+VF+ +N + +K L+ + + + E+ L L+ Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYCHS 150 II+L D + + +V E N D + + ++ + Y +L+A+ H Sbjct: 205 KIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 261 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE---YNVRVASRYFKGPELLVDY 207 GI+H D+KP N +I L+LID+G+A P + +V + + PE + D Sbjct: 262 HGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDM 319 Query: 208 QM----------YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 D+WSLGC+L M + + PF +++ Sbjct: 320 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQIIN 360 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317 + K H +DP+ K + D+L L+ D +QR++ Sbjct: 361 QISKLHAIIDPNHEIEFPDIPEKDLQ----------------DVLKCCLKRDPKQRISIP 404 Query: 318 EAMEHPYFY 326 E + HPY Sbjct: 405 ELLAHPYVQ 413 >4GS6-A nrPDB Length = 315 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 61/312 (19%), Positives = 109/312 (34%), Gaps = 60/312 (19%) Query: 41 QLVRKLGRGKYSEVFEAINITNNERVVVKILKPV-KKKKIKREVKILENLRGGTNIIKLI 99 ++ +GRG + V +A + V +K ++ ++K E++ L + NI+KL Sbjct: 12 EVEEVVGRGAFGVVCKAKWRA--KDVAIKQIESESERKAFIVELRQLSRV-NHPNIVKLY 68 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLYQ------ILTDFDIRFYMYELLKALDYCHS--- 150 +PV LV EY + T + + + + Y HS Sbjct: 69 GACLNPV----CLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQP 124 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 K ++HRD+KP N+++ L++ D+G A S + PE+ + Y Sbjct: 125 KALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT--HMTNNKGSAAWMAPEVF-EGSNY 181 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 D++S G +L +I RR+PF +G ++ P Sbjct: 182 SEKCDVFSWGIILWEVITRRKPF--------------DEIGGPAFRIMWAVHNGTRPPLI 227 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE---AMEH--PYF 325 ++ L+ + D QR + +E M H YF Sbjct: 228 KNLPKPIES---------------------LMTRCWSKDPSQRPSMEEIVKIMTHLMRYF 266 Query: 326 YPVVKEQSQPCA 337 + PC Sbjct: 267 PGADEPLQYPCQ 278 >5X02-A nrPDB Length = 347 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 55/251 (21%), Positives = 103/251 (41%), Gaps = 46/251 (18%) Query: 24 YWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAI-----NITNNERVVVKILK----PV 74 +D + P +++ + + LG G + +V A + +V VK+LK Sbjct: 38 EYDLKWEFP----RENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS 93 Query: 75 KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ------- 127 +++ + E+K++ L NI+ L+ +S L+FEY D + Sbjct: 94 EREALMSELKMMTQLGSHENIVNLLGAC--TLSGPIYLIFEYCCYGDLLNYLRSKREKFS 151 Query: 128 -------------------ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQ 168 +LT D+ + Y++ K +++ K +HRD+ NV++ H Sbjct: 152 EDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH- 210 Query: 169 QKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLAS 225 K +++ D+GLA Y VR +R + PE L + +Y D+WS G +L Sbjct: 211 GKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILLWE 269 Query: 226 MIFRREPFFHG 236 + + G Sbjct: 270 IFSLGVNPYPG 280 >5A46-A nrPDB Length = 386 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 66/306 (21%), Positives = 118/306 (38%), Gaps = 52/306 (16%) Query: 30 HVPSWG-NQDDYQLVRKLGRGKYSEVFEA------INITNN-ERVVVKILKPVKKKK--- 78 P W +D L + LG G + +V A + N +V VK+LK +K Sbjct: 31 EDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLS 90 Query: 79 -IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI--------- 128 + E+++++ + NII L+ ++ EY + + ++ Q Sbjct: 91 DLISEMEMMKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYC 148 Query: 129 ----------LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG 178 L+ D+ Y++ + ++Y SK +HRD+ NV++ + +++ D+G Sbjct: 149 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFG 207 Query: 179 LAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFH 235 LA H Y R + PE L D ++Y + D+WS G +L + + Sbjct: 208 LARDIHHIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYP 266 Query: 236 GQDNYDQLVRIAKVLGTEELYGYLKKYH-IDLDPHFNDILGQHSRKRWENFIHSENRHLV 294 G + EEL+ LK+ H +D + + L R W Sbjct: 267 G-------------VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 313 Query: 295 SPEALD 300 E LD Sbjct: 314 LVEDLD 319 >3GQL-A nrPDB Length = 326 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 66/306 (21%), Positives = 118/306 (38%), Gaps = 52/306 (16%) Query: 30 HVPSWG-NQDDYQLVRKLGRGKYSEVFEA------INITNN-ERVVVKILKPVKKKK--- 78 P W +D L + LG G + +V A + N +V VK+LK +K Sbjct: 19 EDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLS 78 Query: 79 -IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI--------- 128 + E+++++ + NII L+ ++ EY + + ++ Q Sbjct: 79 DLISEMEMMKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYC 136 Query: 129 ----------LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG 178 L+ D+ Y++ + ++Y SK +HRD+ NV++ + +++ D+G Sbjct: 137 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFG 195 Query: 179 LAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFH 235 LA H Y R + PE L D ++Y + D+WS G +L + + Sbjct: 196 LARDIHHIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYP 254 Query: 236 GQDNYDQLVRIAKVLGTEELYGYLKKYH-IDLDPHFNDILGQHSRKRWENFIHSENRHLV 294 G + EEL+ LK+ H +D + + L R W Sbjct: 255 G-------------VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 301 Query: 295 SPEALD 300 E LD Sbjct: 302 LVEDLD 307 >3PPZ-A nrPDB Length = 309 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 61/283 (21%), Positives = 114/283 (40%), Gaps = 36/283 (12%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-----KKKIKREVKILENLRGGT 93 D + K+G G + V A + V VKIL + REV I++ LR Sbjct: 38 DLNIKEKIGAGSFGTVHRAEW--HGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRH-P 94 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI------LTDFDIRFYMYELLKALDY 147 NI+ + V P ++V EY++ +L L + Y++ K ++Y Sbjct: 95 NIVLFMGAVTQP--PNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNY 152 Query: 148 CHSKG--IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-EYNVRVASRYFKGPELL 204 H++ I+HRD+K N+++D + +++ D+GL+ + + PE+L Sbjct: 153 LHNRNPPIVHRDLKSPNLLVDKK-YTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVL 211 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 D + D++S G +L + ++P+ G N Q+V K + Sbjct: 212 RDEPS-NEKSDVYSFGVILWELATLQQPW--GNLNPAQVVAAV----------GFKCKRL 258 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLR 307 ++ + N + W N + +DLL L++ Sbjct: 259 EIPRNLNPQVAAIIEGCWTN---EPWKRPSFATIMDLLRPLIK 298 >5TUR-A nrPDB Length = 404 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 124/312 (39%), Gaps = 61/312 (19%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK---------KIKREVKILE 87 + YQ+ LG G + V+ I +++N V +K ++ + ++ EV +L+ Sbjct: 126 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 185 Query: 88 NLRGG-TNIIKLIDTVKDPVSKTPALVFEYINNT----DFKQLYQILTDFDIRFYMYELL 142 + G + +I+L+D + P + L+ E DF L + R + +++L Sbjct: 186 KVSSGFSGVIRLLDWFERP--DSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 243 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 202 +A+ +CH+ G++HRD+K N++ID + +L+LID+G Y +R + PE Sbjct: 244 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV-YTDFDGTRVYSPPE 302 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 + ++ + S +WSLG +L M+ PF H ++ Sbjct: 303 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRG-------------------- 342 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 R VS E L+ L R T +E H Sbjct: 343 ------------------------QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 378 Query: 323 PYFYPVVKEQSQ 334 P+ V+ Q Sbjct: 379 PWMQDVLLPQET 390 >3OMV-A nrPDB Length = 307 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 57/287 (19%), Positives = 116/287 (40%), Gaps = 36/287 (12%) Query: 15 EVNSLRSRE------YWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVV 68 E N +R R YW+ EA + +G G + V++ + V V Sbjct: 15 EKNKIRPRGQRDSSYYWEIEASEVMLSTR--------IGSGSFGTVYKGKW---HGDVAV 63 Query: 69 KILK-----PVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFK 123 KILK P + + + EV +L R NI+ + A+V ++ + Sbjct: 64 KILKVVDPTPEQFQAFRNEVAVLRKTRH-VNILLFMGY---MTKDNLAIVTQWCEGSSLY 119 Query: 124 QLYQI----LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL 179 + + F + + + +DY H+K I+HRD+K +N+ + H+ +++ D+GL Sbjct: 120 KHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFL-HEGLTVKIGDFGL 178 Query: 180 AEF---YHPAQEYNVRVASRYFKGPELL--VDYQMYDYSLDMWSLGCMLASMIFRREPFF 234 A + +Q+ S + PE++ D + + D++S G +L ++ P+ Sbjct: 179 ATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYS 238 Query: 235 HGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKR 281 H + + + + + +L K + D + + +R Sbjct: 239 HINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEER 285 >4XUF-A nrPDB Length = 297 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 53/239 (22%), Positives = 99/239 (41%), Gaps = 42/239 (17%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAI-----NITNNERVVVKILK----PVKKKKIKREVKIL 86 +++ + + LG G + +V A + +V VK+LK +++ + E+K++ Sbjct: 7 PRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMM 66 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ------------------- 127 L NI+ L+ +S L+FEY D + Sbjct: 67 TQLGSHENIVNLLGAC--TLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRL 124 Query: 128 -------ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180 +LT D+ + Y++ K +++ K +HRD+ NV++ H K +++ D+GLA Sbjct: 125 EEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKICDFGLA 183 Query: 181 EFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHG 236 Y VR +R + PE L + +Y D+WS G +L + + G Sbjct: 184 RDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVNPYPG 241 >3BGP-A nrPDB Length = 333 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 124/312 (39%), Gaps = 61/312 (19%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK---------KIKREVKILE 87 + YQ+ LG G + V+ I +++N V +K ++ + ++ EV +L+ Sbjct: 55 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 114 Query: 88 NLRGG-TNIIKLIDTVKDPVSKTPALVFEYINNT----DFKQLYQILTDFDIRFYMYELL 142 + G + +I+L+D + P + L+ E DF L + R + +++L Sbjct: 115 KVSSGFSGVIRLLDWFERP--DSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 172 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 202 +A+ +CH+ G++HRD+K N++ID + +L+LID+G Y +R + PE Sbjct: 173 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV-YTDFDGTRVYSPPE 231 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 + ++ + S +WSLG +L M+ PF H ++ Sbjct: 232 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRG-------------------- 271 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 R VS E L+ L R T +E H Sbjct: 272 ------------------------QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 307 Query: 323 PYFYPVVKEQSQ 334 P+ V+ Q Sbjct: 308 PWMQDVLLPQET 319 >5HI2-A nrPDB Length = 283 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 56/280 (20%), Positives = 117/280 (41%), Gaps = 23/280 (8%) Query: 33 SWGNQD-DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRG 91 W D + +++G G + V++ + V VK+L P + + K EV +L R Sbjct: 14 DWEIPDGQITVGQRIGSGSFGTVYKGKW---HGDVAVKMLTPQQLQAFKNEVGVLRKTRH 70 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKALDY 147 NI+ + A+V ++ + + + + +DY Sbjct: 71 -VNILLFMGY---STKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDY 126 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF---YHPAQEYNVRVASRYFKGPELL 204 H+K I+HRD+K +N+ + H+ +++ D+GLA + + ++ S + PE++ Sbjct: 127 LHAKSIIHRDLKSNNIFL-HEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 185 Query: 205 --VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 D Y + D+++ G +L ++ + P+ + +N DQ I +++G L L K Sbjct: 186 RMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSN-INNRDQ---IIEMVGRGSLSPDLSKV 241 Query: 263 HIDLDPHFNDILGQ-HSRKRWENFIHSENRHLVSPEALDL 301 + ++ + +KR E + A +L Sbjct: 242 RSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 281 >4R7H-A nrPDB Length = 343 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 57/325 (17%), Positives = 118/325 (36%), Gaps = 56/325 (17%) Query: 12 VYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-----RV 66 + + L E W++ +++ Q + LG G + +V EA + +V Sbjct: 32 TFIDPTQLPYNEKWEF--------PRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKV 83 Query: 67 VVKILKPV----KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDF 122 VK+LK +K+ + E+KI+ +L NI+ L+ ++ EY D Sbjct: 84 AVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH--GGPVLVITEYCTYGDL 141 Query: 123 KQLYQ--------------------------ILTDFDIRFYMYELLKALDYCHSKGIMHR 156 + L D+ + ++ + + + SK +HR Sbjct: 142 LNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHR 201 Query: 157 DVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYS 213 DV NV++ + ++ D+GLA Y V+ +R + PE + D +Y Sbjct: 202 DVAARNVLLTN-GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFD-SVYTVQ 259 Query: 214 LDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDI 273 D+WS G +L + F G + Y ++ +K + + + ++ + Sbjct: 260 SDVWSYGILLWEI------FSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIM 313 Query: 274 LGQHSRKRWENFIHSENRHLVSPEA 298 + + + + +A Sbjct: 314 QACWALEPTHRPTFQQITSFLQEQA 338 >4RC3-A nrPDB Length = 289 Score = 190 bits (484), Expect = 5e-49, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 124/312 (39%), Gaps = 61/312 (19%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK---------KIKREVKILE 87 + YQ+ LG G + V+ I +++N V +K ++ + ++ EV +L+ Sbjct: 11 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 70 Query: 88 NLRGG-TNIIKLIDTVKDPVSKTPALVFEYINNT----DFKQLYQILTDFDIRFYMYELL 142 + G + +I+L+D + P + L+ E DF L + R + +++L Sbjct: 71 KVSSGFSGVIRLLDWFERP--DSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 128 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 202 +A+ +CH+ G++HRD+K N++ID + +L+LID+G Y +R + PE Sbjct: 129 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV-YTDFDGTRVYSPPE 187 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 + ++ + S +WSLG +L M+ PF H ++ Sbjct: 188 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRG-------------------- 227 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 R VS E L+ L R T +E H Sbjct: 228 ------------------------QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 263 Query: 323 PYFYPVVKEQSQ 334 P+ V+ Q Sbjct: 264 PWMQDVLLPQET 275 >3HMP-A nrPDB Length = 342 Score = 190 bits (483), Expect = 7e-49, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 124/309 (40%), Gaps = 63/309 (20%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKI--LKPVKKKKI---KREVKILENLR-GGT 93 Y +++++G G S+VF+ +N + +K L+ + + + E+ L L+ Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYCHS 150 II+L D + + +V E N D + + ++ + Y +L+A+ H Sbjct: 117 KIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 173 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE---YNVRVASRYFKGPELLVDY 207 GI+H D+KP N +I L+LID+G+A P + +V + + PE + D Sbjct: 174 HGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDM 231 Query: 208 QM----------YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 D+WSLGC+L M + + PF +++ Sbjct: 232 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQIIN 272 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317 + K H +DP+ K + D+L L+ D +QR++ Sbjct: 273 QISKLHAIIDPNHEIEFPDIPEKDLQ----------------DVLKCCLKRDPKQRISIP 316 Query: 318 EAMEHPYFY 326 E + HPY Sbjct: 317 ELLAHPYVQ 325 >5H2U-A nrPDB Length = 267 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 51/269 (18%), Positives = 111/269 (41%), Gaps = 18/269 (6%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK---KKKIKREVKILENLRGG 92 ++++ L RKLG G + EVFE + +V +K++ ++ ++ E++ ++ LR Sbjct: 4 PREEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQSEIQAMKKLRH- 61 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKALDY 147 +I+ L V V ++ E + +L + +L ++ +++ + + Y Sbjct: 62 KHILALYAVV--SVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCY 119 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY-FKGPELLVD 206 S+ +HRD+ N+++ + ++ D+GLA + Y + PE L Sbjct: 120 LESQNYIHRDLAARNILVG-ENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL-S 177 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIA---KVLGTEELYGYLKKYH 263 Y D+WS G +L M R + + G N++ +R+ ++ E + K Sbjct: 178 RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLM 237 Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRH 292 + + R + + H Sbjct: 238 LTCWCRDPEQRPTFKALRERLSSFTSHHH 266 >3DLS-A nrPDB Length = 335 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 70/335 (20%), Positives = 128/335 (38%), Gaps = 71/335 (21%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-----------KKIKREVKIL 86 Y + LG G + V+ A++ N+ VVVK +K K K+ E+ IL Sbjct: 24 QKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAIL 83 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD----FKQLYQILTDFDIRFYMYELL 142 + NIIK++D ++ LV E + F + L + + +L+ Sbjct: 84 SRVEHA-NIIKVLDIFENQ--GFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLV 140 Query: 143 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 202 A+ Y K I+HRD+K N++I + ++LID+G A + + + + + PE Sbjct: 141 SAVGYLRLKDIIHRDIKDENIVI-AEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPE 199 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 +L+ L+MWSLG L +++F PF ++ + + Sbjct: 200 VLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIH----------------- 242 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 +LVS E + L+ LL+ ++R T ++ + Sbjct: 243 ---------------------------PPYLVSKELMSLVSGLLQPVPERRTTLEKLVTD 275 Query: 323 PY------FYPVVKEQSQPC--ADNAVLSSGLTAA 349 P+ E+ ++ VLS+ Sbjct: 276 PWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEM 310 >4UY9-A nrPDB Length = 323 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 58/286 (20%), Positives = 111/286 (38%), Gaps = 44/286 (15%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI-------KREVKILENLRG 91 + L +G G + +V+ A I + V VK + + I ++E K+ L+ Sbjct: 10 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 67 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCH 149 NII L LV E+ ++ + + + + ++ + ++Y H Sbjct: 68 -PNIIALRGVCLK--EPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLH 124 Query: 150 SKGI---MHRDVKPHNVMI-------DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK 199 + I +HRD+K N++I D K L++ D+GLA +H + + + + Sbjct: 125 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGTYAWM 183 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE++ M+ D+WS G +L ++ PF G D +A + Sbjct: 184 APEVIR-ASMFSKGSDVWSYGVLLWELLTGEVPF-RGIDGLAVAYGVA-----------M 230 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKL 305 K + + + + W HS P ++LD+L Sbjct: 231 NKLALPIPSTCPEPFAKLMEDCWNPDPHSR------PSFTNILDQL 270 >3CJF-A nrPDB Length = 309 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 62/314 (19%), Positives = 120/314 (38%), Gaps = 65/314 (20%) Query: 36 NQDDYQLVRKLGRGKYSEVFEA----INIT-NNERVVVKILKP----VKKKKIKREVKIL 86 +D L + LGRG + +V EA I+ T V VK+LK + + + E+KIL Sbjct: 25 PRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKIL 84 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---------------ILTD 131 ++ N++ L+ P +V E+ + + LT Sbjct: 85 IHIGHHLNVVNLLGACTKPGGPLMVIV-EFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTL 143 Query: 132 FDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV 191 + Y +++ K +++ S+ +HRD+ N+++ + +++ D+GLA + +Y Sbjct: 144 EHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKN-VVKICDFGLARDIYKDPDYVR 202 Query: 192 RVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 + +R + PE + D ++Y D+WS G +L + + G Sbjct: 203 KGDARLPLKWMAPETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPG------------ 249 Query: 249 VLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRY 308 + +D F L + +R R ++ E + Sbjct: 250 ---------------VKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLD--------CWHG 286 Query: 309 DHQQRLTAKEAMEH 322 + QR T E +EH Sbjct: 287 EPSQRPTFSELVEH 300 >2PSQ-A nrPDB Length = 370 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 65/314 (20%), Positives = 122/314 (38%), Gaps = 55/314 (17%) Query: 30 HVPSWG-NQDDYQLVRKLGRGKYSEVFEA----INITNNER---VVVKILKPVKKKK--- 78 P W +D L + LG G + +V A I+ + V VK+LK +K Sbjct: 72 EDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLS 131 Query: 79 -IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI--------- 128 + E+++++ + NII L+ ++ EY + + ++ + Sbjct: 132 DLVSEMEMMKMIGKHKNIINLLGACTQ--DGPLYVIVEYASKGNLREYLRARRPPGMEYS 189 Query: 129 ----------LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG 178 +T D+ Y+L + ++Y S+ +HRD+ NV++ + +++ D+G Sbjct: 190 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT-ENNVMKIADFG 248 Query: 179 LAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFH 235 LA + Y R + PE L D ++Y + D+WS G ++ + + Sbjct: 249 LARDINNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYP 307 Query: 236 GQDNYDQLVRIAKVLGTEELYGYLKKYH-IDLDPHFNDILGQHSRKRWENFIHSENRHLV 294 G + EEL+ LK+ H +D + + L R W R Sbjct: 308 G-------------IPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAV--PSQRPTF 352 Query: 295 SPEALDLLDKLLRY 308 DL D++L Sbjct: 353 KQLVEDL-DRILTL 365 >2H8H-A nrPDB Length = 535 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 56/311 (18%), Positives = 117/311 (37%), Gaps = 56/311 (18%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP--VKKKKIKREVKILENLRGGT 93 ++ +L KLG+G + EV+ RV +K LKP + + +E ++++ LR Sbjct: 265 PRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 323 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKALDYC 148 +++L V + +V EY++ + L + ++ + Y Sbjct: 324 -LVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 379 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLV 205 +HRD++ N+++ + ++ D+GLA EY R +++ + PE + Sbjct: 380 ERMNYVHRDLRAANILVG-ENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAAL 437 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 Y + D+WS G +L + + + G N + L ++ + Y + Sbjct: 438 -YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER------------GYRMP 484 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK--EAMEHP 323 P + L DL+ + R + ++R T + +A Sbjct: 485 CPPECPESLH------------------------DLMCQCWRKEPEERPTFEYLQAFLED 520 Query: 324 YFYPVVKEQSQ 334 YF + Sbjct: 521 YFTSTEPQYQP 531 >6F3F-A nrPDB Length = 455 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 57/311 (18%), Positives = 117/311 (37%), Gaps = 56/311 (18%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP--VKKKKIKREVKILENLRGGT 93 ++ +L KLG+G + EV+ RV +K LKP + + +E ++++ LR Sbjct: 185 PRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 243 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKALDYC 148 +++L V + +V EY+N + L + ++ + Y Sbjct: 244 -LVQLYAVVSEE---PIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYV 299 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLV 205 +HRD++ N+++ + ++ D+GLA EY R +++ + PE + Sbjct: 300 ERMNYVHRDLRAANILVG-ENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAAL 357 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 Y + D+WS G +L + + + G N + L ++ + Y + Sbjct: 358 -YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER------------GYRMP 404 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK--EAMEHP 323 P + L DL+ + R + ++R T + +A Sbjct: 405 CPPECPESLH------------------------DLMCQCWRKEPEERPTFEYLQAFLED 440 Query: 324 YFYPVVKEQSQ 334 YF + Sbjct: 441 YFTSTEPQYQP 451 >5AP3-A nrPDB Length = 313 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 124/309 (40%), Gaps = 63/309 (20%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKI--LKPVKKKKI---KREVKILENLR-GGT 93 Y +++++G G S+VF+ +N + +K L+ + + + E+ L L+ Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYCHS 150 II+L D + + +V E N D + + ++ + Y +L+A+ H Sbjct: 89 KIIRLYDY--EITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 145 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE---YNVRVASRYFKGPELLVDY 207 GI+H D+KP N +I L+LID+G+A P + +V + + PE + D Sbjct: 146 HGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDM 203 Query: 208 QM----------YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 D+WSLGC+L M + + PF +++ Sbjct: 204 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQIIN 244 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317 + K H +DP+ K + D+L L+ D +QR++ Sbjct: 245 QISKLHAIIDPNHEIEFPDIPEKDLQ----------------DVLKCCLKRDPKQRISIP 288 Query: 318 EAMEHPYFY 326 E + HPY Sbjct: 289 ELLAHPYVQ 297 >4XEY-B nrPDB Length = 408 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 50/302 (16%), Positives = 111/302 (36%), Gaps = 22/302 (7%) Query: 12 VYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL 71 Y + Y + + D + KLG G+Y EV+E + + V VK L Sbjct: 99 HYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL 158 Query: 72 K--PVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL 129 K ++ ++ +E +++ ++ N+++L+ ++ E++ + + Sbjct: 159 KEDTMEVEEFLKEAAVMKEIKH-PNLVQLLGVCTR--EPPFYIITEFMTYGNLLDYLREC 215 Query: 130 TDFDI-----RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH 184 ++ + ++ A++Y K +HRD+ N ++ + +++ D+GL+ Sbjct: 216 NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM- 273 Query: 185 PAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYD 241 Y +++ + PE L Y + D+W+ G +L + + G D Sbjct: 274 TGDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 332 Query: 242 QLV------RIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS 295 R+ + G E L + +P + + F S V Sbjct: 333 VYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVE 392 Query: 296 PE 297 E Sbjct: 393 KE 394 >3DTC-A nrPDB Length = 271 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 58/286 (20%), Positives = 111/286 (38%), Gaps = 44/286 (15%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI-------KREVKILENLRG 91 + L +G G + +V+ A I + V VK + + I ++E K+ L+ Sbjct: 8 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 65 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCH 149 NII L LV E+ ++ + + + + ++ + ++Y H Sbjct: 66 -PNIIALRGVCLK--EPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLH 122 Query: 150 SKGI---MHRDVKPHNVMI-------DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK 199 + I +HRD+K N++I D K L++ D+GLA +H + + + + Sbjct: 123 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGAYAWM 181 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE++ M+ D+WS G +L ++ PF G D +A + Sbjct: 182 APEVIR-ASMFSKGSDVWSYGVLLWELLTGEVPF-RGIDGLAVAYGVA-----------M 228 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKL 305 K + + + + W HS P ++LD+L Sbjct: 229 NKLALPIPSTCPEPFAKLMEDCWNPDPHSR------PSFTNILDQL 268 >2W1I-A nrPDB Length = 326 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 56/297 (18%), Positives = 118/297 (39%), Gaps = 35/297 (11%) Query: 27 YEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAI----NITNNERVVVKILKPVKKK---KI 79 +E P+ + + +++LG+G + V E V VK L+ ++ Sbjct: 30 FEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDF 89 Query: 80 KREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDF----DIR 135 +RE++IL++L+ NI+K + L+ EY+ + Q + + Sbjct: 90 EREIEILKSLQH-DNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLL 148 Query: 136 FYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN----V 191 Y ++ K ++Y +K +HRD+ N++++++ ++++ D+GL + +EY Sbjct: 149 QYTSQICKGMEYLGTKRYIHRDLATRNILVENEN-RVKIGDFGLTKVLPQDKEYYKVKEP 207 Query: 192 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-----RREP--FFHGQDNYDQLV 244 + ++ PE L + + + + D+WS G +L + + P F N Q Sbjct: 208 GESPIFWYAPESLTESK-FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQ 266 Query: 245 RIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDL 301 I L + + D + + W N ++ P DL Sbjct: 267 MIVFHL----IELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQR------PSFRDL 313 >2PL0-A nrPDB Length = 289 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 51/278 (18%), Positives = 112/278 (40%), Gaps = 34/278 (12%) Query: 17 NSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PV 74 + +W+ E VP ++ +LV +LG G++ EV+ + +V VK LK + Sbjct: 6 TQKPQKPWWEDEWEVP----RETLKLVERLGAGQFGEVWMGYY-NGHTKVAVKSLKQGSM 60 Query: 75 KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----IL 129 E +++ L+ +++L V + ++ EY+ N + L Sbjct: 61 SPDAFLAEANLMKQLQHQR-LVRLYAVV---TQEPIYIITEYMENGSLVDFLKTPSGIKL 116 Query: 130 TDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY 189 T + ++ + + + + +HRD++ N+++ ++ D+GLA EY Sbjct: 117 TINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLIED-NEY 174 Query: 190 NVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRI 246 R +++ + PE + +Y + D+WS G +L ++ + G N + + + Sbjct: 175 TAREGAKFPIKWTAPEAI-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL 233 Query: 247 AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWEN 284 + Y + + + L Q R W+ Sbjct: 234 ER------------GYRMVRPDNCPEELYQLMRLCWKE 259 >4EBW-A nrPDB Length = 304 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 56/290 (19%), Positives = 108/290 (37%), Gaps = 34/290 (11%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNER---VVVKILKPVK----KKKIKREVKILEN 88 ++ +L R +G G++ +V + I ++ V +K K ++K +E + Sbjct: 36 QRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQ 95 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKA 144 +I+KLI + ++ E + + Q+ L + Y Y+L A Sbjct: 96 F-DHPHIVKLIGVI---TENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTA 151 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY--FKGPE 202 L Y SK +HRD+ NV++ ++L D+GL+ + + Y + PE Sbjct: 152 LAYLESKRFVHRDIAARNVLVSSNDC-VKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE 210 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 + +++ + + D+W G + ++ F G N D + RI Sbjct: 211 SI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIEN------------GE 257 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQ 312 + + P+ L K W R E L +L + Q Sbjct: 258 RLPMPPNCPPTLYSLMTKCWAYDPSRRPRFT---ELKAQLSTILEEEKAQ 304 >2ZMD-A nrPDB Length = 390 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 124/309 (40%), Gaps = 63/309 (20%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKI--LKPVKKKKI---KREVKILENLR-GGT 93 Y +++++G G S+VF+ +N + +K L+ + + + E+ L L+ Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALDYCHS 150 II+L D + + +V E N D + + ++ + Y +L+A+ H Sbjct: 117 KIIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQ 173 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE---YNVRVASRYFKGPELLVDY 207 GI+H D+KP N +I L+LID+G+A P + +V + + PE + D Sbjct: 174 HGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDM 231 Query: 208 QM----------YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 D+WSLGC+L M + + PF +++ Sbjct: 232 SSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-------------------QQIIN 272 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317 + K H +DP+ K + D+L L+ D +QR++ Sbjct: 273 QISKLHAIIDPNHEIEFPDIPEKDLQ----------------DVLKCCLKRDPKQRISIP 316 Query: 318 EAMEHPYFY 326 E + HPY Sbjct: 317 ELLAHPYVQ 325 >4EQM-A nrPDB Length = 294 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 68/285 (23%), Positives = 120/285 (42%), Gaps = 27/285 (9%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENLRG 91 + Y++V KLG G S V+ A + N +V +K + K K+ +REV L Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSH 70 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYC 148 NI+ +ID D LV EYI + + L+ + ++L + + Sbjct: 71 Q-NIVSMIDV--DEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHA 127 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ--EYNVRVASRYFKGPELLVD 206 H I+HRD+KP N++ID K L++ D+G+A+ + N + + + PE Sbjct: 128 HDMRIVHRDIKPQNILIDS-NKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPE-QAK 185 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 + D D++S+G +L M+ PF N + V IA + + D+ Sbjct: 186 GEATDECTDIYSIGIVLYEMLVGEPPF-----NGETAVSIAIKHIQDSVPNVTTDVRKDI 240 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQ 311 ++++ + + K NR+ E D L +L + Sbjct: 241 PQSLSNVILRATEKD------KANRYKTIQEMKDDLSSVLHENRA 279 >6DBN-A nrPDB Length = 316 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 61/268 (22%), Positives = 114/268 (42%), Gaps = 33/268 (12%) Query: 40 YQLVRKLGRGKYSEVFEAI----NITNNERVVVKILKPVKK----KKIKREVKILENLRG 91 + +R LG G + +V E+V VK LKP +K+E++IL NL Sbjct: 37 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYH 96 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY----QILTDFDIRFYMYELLKALDY 147 NI+K + L+ E++ + K+ + Y ++ K +DY Sbjct: 97 -ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDY 155 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY----NVRVASRYFKGPEL 203 S+ +HRD+ NV+++ + ++++ D+GL + +EY + R + ++ PE Sbjct: 156 LGSRQYVHRDLAARNVLVESEH-QVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC 214 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG-------TEELY 256 L+ + Y + D+WS G L ++ + + + K++G L Sbjct: 215 LMQSKFY-IASDVWSFGVTLHELLT------YCDSDSSPMALFLKMIGPTHGQMTVTRLV 267 Query: 257 GYLKKY-HIDLDPHFNDILGQHSRKRWE 283 LK+ + P+ D + Q RK WE Sbjct: 268 NTLKEGKRLPCPPNCPDEVYQLMRKCWE 295 >5HIE-A nrPDB Length = 302 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 57/280 (20%), Positives = 119/280 (42%), Gaps = 23/280 (8%) Query: 33 SWGNQD-DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRG 91 W D + +++G G + V++ + V VK+L P + + K EV +L R Sbjct: 30 DWEIPDGQITVGQRIGSGSFGTVYKGKW---HGDVAVKMLTPQQLQAFKNEVGVLRKTRH 86 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDF----DIRFYMYELLKALDY 147 NI+ + A+V ++ + I+ + + + +DY Sbjct: 87 -VNILLFMGY---STKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDY 142 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF---YHPAQEYNVRVASRYFKGPELL 204 H+K I+HRD+K +N+ + H+ +++ D+GLA + + ++ S + PE++ Sbjct: 143 LHAKSIIHRDLKSNNIFL-HEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 201 Query: 205 --VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 D Y + D+++ G +L ++ + P+ + +N DQ I ++G L L K Sbjct: 202 RMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSN-INNRDQ---IIFMVGRGYLSPDLSKV 257 Query: 263 HIDLDPHFNDILGQ-HSRKRWENFIHSENRHLVSPEALDL 301 + ++ + +KR E + + + A L Sbjct: 258 RSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL 297 >2DQ7-X nrPDB Length = 283 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 48/272 (17%), Positives = 109/272 (40%), Gaps = 18/272 (6%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP--VKKKKIKREVKILENLRGGT 93 ++ QL+++LG G++ EV+ N +V +K LKP + + E +I++ L+ Sbjct: 7 PRESLQLIKRLGNGQFGEVWMGTW-NGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 65 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-----QILTDFDIRFYMYELLKALDYC 148 +++L V + +V EY+N + L ++ ++ + Y Sbjct: 66 -LVQLYAVVSEE---PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 121 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLV 205 +HRD++ N+++ + ++ D+GLA EY R +++ + PE + Sbjct: 122 ERMNYIHRDLRSANILVGN-GLICKIADFGLARLIED-NEYTARQGAKFPIKWTAPEAAL 179 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 Y + D+WS G +L ++ + + G +N + L ++ + H Sbjct: 180 -YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHEL 238 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPE 297 + + + + + P+ Sbjct: 239 MIHCWKKDPEERPTFEYLQSFLEDYFTATEPQ 270 >2FO0-A nrPDB Length = 495 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 49/302 (16%), Positives = 111/302 (36%), Gaps = 22/302 (7%) Query: 12 VYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL 71 Y + Y + + D + KLG G+Y EV+E + + V VK L Sbjct: 191 HYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTL 250 Query: 72 K--PVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL 129 K ++ ++ +E +++ ++ N+++L+ ++ E++ + + Sbjct: 251 KEDTMEVEEFLKEAAVMKEIKH-PNLVQLLGVCTR--EPPFYIITEFMTYGNLLDYLREC 307 Query: 130 TDFDI-----RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH 184 ++ + ++ A++Y K +HR++ N ++ + +++ D+GL+ Sbjct: 308 NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVG-ENHLVKVADFGLSRLM- 365 Query: 185 PAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYD 241 Y +++ + PE L Y + D+W+ G +L + + G D Sbjct: 366 TGDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 424 Query: 242 QLV------RIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS 295 R+ + G E L + +P + + F S V Sbjct: 425 VYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVE 484 Query: 296 PE 297 E Sbjct: 485 KE 486 >4XCU-A nrPDB Length = 300 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 63/296 (21%), Positives = 112/296 (37%), Gaps = 43/296 (14%) Query: 31 VPSWG-NQDDYQLVRKLGRGKYSEVFEAI-------NITNNERVVVKILKPVKKKK---- 78 P W +D L + LG G + +V A V VK+LK K Sbjct: 9 DPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLAD 68 Query: 79 IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----------I 128 + E+++++ + NII L+ ++ E + ++ + Sbjct: 69 LVSEMEVMKLIGRHKNIINLLGVCTQ--EGPLYVIVECAAKGNLREFLRARRPPGSSEGP 126 Query: 129 LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE 188 L+ + Y++ + + Y S+ +HRD+ NV++ + +++ D+GLA H Sbjct: 127 LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVT-EDNVMKIADFGLARGVHHIDY 185 Query: 189 YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR 245 Y R + PE L D ++Y + D+WS G +L + + G Sbjct: 186 YKKTSNGRLPVKWMAPEALFD-RVYTHQSDVWSFGILLWEIFTLGGSPYPG--------- 235 Query: 246 IAKVLGTEELYGYLKKYH-IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300 + EEL+ L++ H +D PH L R+ W EALD Sbjct: 236 ----IPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 287 >5SYS-A nrPDB Length = 286 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 56/311 (18%), Positives = 116/311 (37%), Gaps = 56/311 (18%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP--VKKKKIKREVKILENLRGGT 93 ++ +L KLG+G + E + RV +K LKP + + +E ++++ LR Sbjct: 16 PRESLRLEVKLGQGCFGECWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 74 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKALDYC 148 +++L V + +V EY++ + L + ++ + Y Sbjct: 75 -LVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYV 130 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLV 205 +HRD++ N+++ + ++ D+GLA EY R +++ + PE + Sbjct: 131 ERMNYVHRDLRAANILVG-ENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAAL 188 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 Y + D+WS G +L + + + G N + L ++ + Y + Sbjct: 189 -YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER------------GYRMP 235 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK--EAMEHP 323 P + L DL+ + R D ++R T + +A Sbjct: 236 CPPECPESLH------------------------DLMCQCWRKDPEERPTFEYLQAFLED 271 Query: 324 YFYPVVKEQSQ 334 YF + Sbjct: 272 YFTSTEPQYQP 282 >2J0K-A nrPDB Length = 656 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 51/260 (19%), Positives = 101/260 (38%), Gaps = 31/260 (11%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNER---VVVKILKPVK----KKKIKREVKILEN 88 ++ +L R +G G++ +V + I ++ V +K K ++K +E + Sbjct: 388 QRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQ 447 Query: 89 LRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKA 144 +I+KLI + ++ E + + Q+ L + Y Y+L A Sbjct: 448 F-DHPHIVKLIGVI---TENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTA 503 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY--FKGPE 202 L Y SK +HRD+ NV++ ++L D+GL+ + + Y + PE Sbjct: 504 LAYLESKRFVHRDIAARNVLVSATDC-VKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE 562 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 + +++ + + D+W G + ++ F G N D + RI Sbjct: 563 SI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIEN------------GE 609 Query: 263 HIDLDPHFNDILGQHSRKRW 282 + + P+ L K W Sbjct: 610 RLPMPPNCPPTLYSLMTKCW 629 >4K33-A nrPDB Length = 325 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 121/313 (38%), Gaps = 55/313 (17%) Query: 31 VPSWG-NQDDYQLVRKLGRGKYSEVF--EAINITNNE-----RVVVKILKPVKKKK---- 78 P W ++ L + LG G + +V EAI I + V VK+LK K Sbjct: 28 DPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSD 87 Query: 79 IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI---------- 128 + E+++++ + NII L+ ++ EY + ++ + Sbjct: 88 LVSEMEMMKMIGKHKNIINLLGACTQ--GGPLYVLVEYAAKGNLREFLRARRPPGLDYSF 145 Query: 129 ---------LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL 179 LT D+ Y++ + ++Y S+ +HRD+ NV++ + +++ D+GL Sbjct: 146 DTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVT-EDNVMKIADFGL 204 Query: 180 AEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHG 236 A H Y R + PE L D ++Y + D+WS G +L + + G Sbjct: 205 ARDVHNLDYYKETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLLWEIFTLGGSPYPG 263 Query: 237 QDNYDQLVRIAKVLGTEELYGYLKKYH-IDLDPHFNDILGQHSRKRWENFIHSENRHLVS 295 + EEL+ LK+ H +D + L R+ W R Sbjct: 264 -------------IPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHA--APSQRPTFK 308 Query: 296 PEALDLLDKLLRY 308 DL D++L Sbjct: 309 QLVEDL-DRVLTV 320 >3ORP-A nrPDB Length = 311 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 55/214 (25%), Positives = 98/214 (45%), Gaps = 18/214 (8%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVKILEN 88 D Y+L LG G SEV A ++ ++ V VK+L+ P + +RE + Sbjct: 9 HLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAA 68 Query: 89 LRGGTNIIKLIDT--VKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLK 143 L I+ + DT + P P +V EY++ + + +T + + + Sbjct: 69 L-NHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQ 127 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR----VASRYFK 199 AL++ H GI+HRDVKP N+MI ++++D+G+A + + + + + Sbjct: 128 ALNFSHQNGIIHRDVKPANIMISATN-AVKVMDFGIARAIADSGNSVTQTAAVIGTAQYL 186 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 PE + D D++SLGC+L ++ PF Sbjct: 187 SPEQARGDSV-DARSDVYSLGCVLYEVLTGEPPF 219 >3A4O-X nrPDB Length = 286 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 48/278 (17%), Positives = 119/278 (42%), Gaps = 22/278 (7%) Query: 23 EYWDYEAHVPSWG-NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP--VKKKKI 79 + WD +A W ++ +LV++LG G++ EV+ N+ +V VK LKP + + Sbjct: 1 KPWDKDA----WEIPRESIKLVKRLGAGQFGEVWMGYY-NNSTKVAVKTLKPGTMSVQAF 55 Query: 80 KREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----ILTDFDI 134 E +++ L+ +++L V + ++ EY+ + + + Sbjct: 56 LEEANLMKTLQHDK-LVRLYAVVTR--EEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKL 112 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVA 194 + ++ + + Y K +HRD++ NV++ + ++ D+GLA EY R Sbjct: 113 IDFSAQIAEGMAYIERKNYIHRDLRAANVLVS-ESLMCKIADFGLARVIED-NEYTAREG 170 Query: 195 SRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG 251 +++ + PE + ++ + D+WS G +L ++ + + G+ N D + +++ Sbjct: 171 AKFPIKWTAPEAI-NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYR 229 Query: 252 TEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSE 289 + + + + + + + + + + Sbjct: 230 MPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDD 267 >5EG3-A nrPDB Length = 334 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 63/314 (20%), Positives = 121/314 (38%), Gaps = 55/314 (17%) Query: 30 HVPSWG-NQDDYQLVRKLGRGKYSEVFEA----INITNNER---VVVKILKPVKKKK--- 78 P W +D L + LG G + +V A I+ + V VK+LK +K Sbjct: 26 EDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLS 85 Query: 79 -IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI--------- 128 + E+++++ + NII L+ ++ Y + + ++ + Sbjct: 86 DLVSEMEMMKMIGKHKNIINLLGACTQ--DGPLYVIVAYASKGNLREYLRARRPPGMELS 143 Query: 129 ----------LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG 178 +T D+ Y+L + ++Y S+ +HRD+ NV++ + +++ D+G Sbjct: 144 PDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT-ENNVMKIADFG 202 Query: 179 LAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFH 235 LA + + R + PE L D ++Y + D+WS G ++ + + Sbjct: 203 LARDINNIDFFKETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYP 261 Query: 236 GQDNYDQLVRIAKVLGTEELYGYLKKYH-IDLDPHFNDILGQHSRKRWENFIHSENRHLV 294 G + EEL+ LK+ H +D + + L R W R Sbjct: 262 G-------------IPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAV--PSQRPTF 306 Query: 295 SPEALDLLDKLLRY 308 DL D++L Sbjct: 307 KQLVEDL-DRILTL 319 >4UYA-A nrPDB Length = 340 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 105/269 (39%), Gaps = 38/269 (14%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-------KKIKREVKILENLR 90 + +L +G G + +V+ A + V VK + + + ++RE ++ LR Sbjct: 26 ERLELKELIGAGGFGQVYRATW--QGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLR 83 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--QILTDFDIRFYMYELLKALDYC 148 NII+L LV E+ + + + + + ++ + + Y Sbjct: 84 H-PNIIELRGVCLQQ--PHLCLVLEFARGGALNRALAGRRIPPHVLVNWAVQIARGMLYL 140 Query: 149 HSKG---IMHRDVKPHNVMI-------DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYF 198 H + I+HRD+K N+++ D K L++ D+GLA +H + + + Sbjct: 141 HEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMAT-AGAYAW 199 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258 PE++ ++ D+WS G +L ++ P + G D +A Sbjct: 200 MAPEVI-KSSLFSKGSDIWSYGVLLWELLTGEVP-YRGIDGLAVAYGVA----------- 246 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIH 287 + K + + + + ++ W+ H Sbjct: 247 VNKLTLPIPSTCPEPFAKLMKECWQQDPH 275 >4XLV-A nrPDB Length = 328 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 66/357 (18%), Positives = 131/357 (36%), Gaps = 76/357 (21%) Query: 7 GSRARVYAEVNS--LRSREYWDYEAHVPS-WG-NQDDYQLVRKLGRGKYSEVFE--AINI 60 G ++A N L + + + +VP W +++ L+R+LG+G + V+E A +I Sbjct: 4 GPLGPLFASSNPEYLSASDVFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDI 63 Query: 61 TNNE---RVVVKILKPV----KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALV 113 E RV VK + ++ + E +++ ++++L+ V + +V Sbjct: 64 IKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLLGVV--SKGQPTLVV 120 Query: 114 FEYINNTDFKQLYQILTDF-------------DIRFYMYELLKALDYCHSKGIMHRDVKP 160 E + + D K + L ++ E+ + Y ++K +HRD+ Sbjct: 121 MELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAA 180 Query: 161 HNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVA---SRYFKGPELLVDYQMYDYSLDMW 217 N M+ H +++ D+G+ + Y + PE L D ++ S DMW Sbjct: 181 RNCMVAH-DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKD-GVFTTSSDMW 238 Query: 218 SLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQH 277 S G +L + E + G N L + + ++D + + + Sbjct: 239 SFGVVLWEITSLAEQPYQGLSNEQVLKFV------------MDGGYLDQPDNCPERVT-- 284 Query: 278 SRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME------HPYFYPV 328 DL+ +++ R T E + HP F V Sbjct: 285 ----------------------DLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEV 319 >3V5Q-A nrPDB Length = 297 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 62/322 (19%), Positives = 116/322 (36%), Gaps = 74/322 (22%) Query: 29 AHVPSWGNQDDYQLVRKLGRGKYSEVFEAIN-----ITNNERVVVKILKP---VKKKKIK 80 HV +D L R+LG G + +VF A + V VK LK +K + Sbjct: 7 IHVQHIKRRD-IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQ 65 Query: 81 REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI------------ 128 RE ++L NL+ +I+K D +VFEY+ + D + + Sbjct: 66 REAELLTNLQH-EHIVKFYGVCGD--GDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQ 122 Query: 129 -------LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE 181 L + ++ + Y S+ +HRD+ N ++ +++ D+G++ Sbjct: 123 PRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA-NLLVKIGDFGMSR 181 Query: 182 FYHPAQEYNVRVASR---YFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRREPFFHGQ 237 + Y V + + PE ++ Y+ + D+WS G +L + + ++P+F Sbjct: 182 DVYSTDYYRVGGHTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQ-L 239 Query: 238 DNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPE 297 N + + I + E + E Sbjct: 240 SNTEVIECITQGRVLERP------------------------------------RVCPKE 263 Query: 298 ALDLLDKLLRYDHQQRLTAKEA 319 D++ + + QQRL KE Sbjct: 264 VYDVMLGCWQREPQQRLNIKEI 285 >5GRN-A nrPDB Length = 356 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 58/266 (21%), Positives = 107/266 (40%), Gaps = 53/266 (19%) Query: 12 VYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFE--AINITNNE---RV 66 +Y + L W++ +D L R LG G + +V E A ++ ++ +V Sbjct: 28 IYVDPMQLPYDSRWEF--------PRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKV 79 Query: 67 VVKILKPV----KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDF 122 VK+LKP +K+ + E+KI+ +L NI+ L+ S ++ EY D Sbjct: 80 AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGAC--TKSGPIYIITEYCFYGDL 137 Query: 123 KQLYQI-----------------------------LTDFDIRFYMYELLKALDYCHSKGI 153 LT D+ + Y++ + +++ SK Sbjct: 138 VNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNC 197 Query: 154 MHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVAS---RYFKGPELLVDYQMY 210 +HRD+ NV++ Q K +++ D+GLA Y + ++ + PE + D +Y Sbjct: 198 VHRDLAARNVLL-AQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFD-NLY 255 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHG 236 D+WS G +L + + G Sbjct: 256 TTLSDVWSYGILLWEIFSLGGTPYPG 281 >4PL5-B nrPDB Length = 435 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 66/305 (21%), Positives = 123/305 (40%), Gaps = 60/305 (19%) Query: 45 KLGRGKYSE-VFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVK 103 LG G V++ + +N V VK + P REV++L N+I+ T K Sbjct: 34 VLGHGAEGTIVYKG--MFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEK 91 Query: 104 DPVSKTPALVF------EYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRD 157 D + A+ EY+ DF L + +++ L + HS I+HRD Sbjct: 92 DRQFQYIAIELCAATLQEYVEQKDFAHL-----GLEPITLLHQTTSGLAHLHSLNIVHRD 146 Query: 158 VKPHNVMID--HQQKKLR--LIDWGLAEFY----HPAQEYNVRVASRYFKGPELLVD--Y 207 +KPHN+++ + +++ + D+GL + H + + + PE+L + Sbjct: 147 LKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCK 206 Query: 208 QMYDYSLDMWSLGCMLASMIF-RREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 Y++D++S GC+ +I PF G+ Q + + + + I Sbjct: 207 DNPTYTVDIFSAGCVFYYVISEGYHPF--GKSLQRQANILLGACNLDCFHSDKHEDVI-- 262 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 A +L++K++ D QQR +AK ++HP+F+ Sbjct: 263 -------------------------------ARELIEKMIAMDPQQRPSAKHVLKHPFFW 291 Query: 327 PVVKE 331 + K+ Sbjct: 292 SLEKQ 296 >6HV0-A nrPDB Length = 416 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 120/305 (39%), Gaps = 60/305 (19%) Query: 45 KLGRGKYSE-VFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVK 103 LG G V+ + +N V VK + P REV++L N+I+ T K Sbjct: 15 VLGHGAEGTIVYRG--MFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEK 72 Query: 104 DPVSKTPALVF------EYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRD 157 D + A+ EY+ DF L + + + L + HS I+HRD Sbjct: 73 DRQFQYIAIELCAATLQEYVEQKDFAHL-----GLEPITLLQQTTSGLAHLHSLNIVHRD 127 Query: 158 VKPHNVMIDHQQKKLR----LIDWGLAEFY----HPAQEYNVRVASRYFKGPELLVD--Y 207 +KPHN++I + + D+GL + H + + + PE+L + Sbjct: 128 LKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCK 187 Query: 208 QMYDYSLDMWSLGCMLASMIF-RREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 + Y++D++S GC+ +I PF G+ Q + + L+ + I Sbjct: 188 ENPTYTVDIFSAGCVFYYVISEGSHPF--GKSLQRQANILLGACSLDCLHPEKHEDVI-- 243 Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 A +L++K++ D Q+R +AK ++HP+F+ Sbjct: 244 -------------------------------ARELIEKMIAMDPQKRPSAKHVLKHPFFW 272 Query: 327 PVVKE 331 + K+ Sbjct: 273 SLEKQ 277 >6NPU-A nrPDB Length = 298 Score = 184 bits (466), Expect = 8e-47, Method: Composition-based stats. Identities = 48/277 (17%), Positives = 107/277 (38%), Gaps = 22/277 (7%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGTN 94 + D + KLG G+Y EV+E + + V VK LK ++ ++ +E +++ ++ N Sbjct: 25 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH-PN 83 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI-----RFYMYELLKALDYCH 149 +++L+ ++ E++ + + ++ + ++ A++Y Sbjct: 84 LVQLLGVCTR--EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 141 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVD 206 K +HRD+ N ++ + +++ D+GL+ Y +++ + PE L Sbjct: 142 KKNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA- 198 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLV------RIAKVLGTEELYGYLK 260 Y + D+W+ G +L + + G D R+ + G E L Sbjct: 199 YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELM 258 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPE 297 + +P + + F S V E Sbjct: 259 RACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKE 295 >4HVI-A nrPDB Length = 314 Score = 184 bits (466), Expect = 8e-47, Method: Composition-based stats. Identities = 53/275 (19%), Positives = 113/275 (41%), Gaps = 32/275 (11%) Query: 31 VPSWGNQDDYQLVRKLGRGKYSEVFEAI----NITNNERVVVKILK---PVKKKKIKREV 83 P+ + + + +LG+G + V V VK L+ P +++ +RE+ Sbjct: 3 DPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREI 62 Query: 84 KILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMY 139 +IL+ L I+K P ++ LV EY+ + + Q L + Y Sbjct: 63 QILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSS 121 Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV----AS 195 ++ K ++Y S+ +HRD+ N++++ + +++ D+GLA+ ++Y V + Sbjct: 122 QICKGMEYLGSRRCVHRDLAARNILVESE-AHVKIADFGLAKLLPLDKDYYVVREPGQSP 180 Query: 196 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEEL 255 ++ PE L D ++ D+WS G +L + F + + +++G+E Sbjct: 181 IFWYAPESLSD-NIFSRQSDVWSFGVVLYEL------FTYCDKSCSPSAEFLRMMGSERD 233 Query: 256 YGYLKKY--------HIDLDPHFNDILGQHSRKRW 282 L + + P + + + W Sbjct: 234 VPALSRLLELLEEGQRLPAPPACPAEVHELMKLCW 268 >4X7Q-B nrPDB Length = 312 Score = 183 bits (465), Expect = 9e-47, Method: Composition-based stats. Identities = 63/315 (20%), Positives = 119/315 (37%), Gaps = 65/315 (20%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP---------VKKKKIKREVKILE 87 + +Y+L LG+G + VF +T+ +V +K++ EV +L Sbjct: 30 EAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLW 89 Query: 88 NLR---GGTNIIKLIDTVKDPVSKTPALVFEY-INNTDFKQLYQ---ILTDFDIRFYMYE 140 + G +I+L+D + + LV E + D L + R + + Sbjct: 90 KVGAGGGHPGVIRLLDWFE--TQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQ 147 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG 200 ++ A+ +CHS+G++HRD+K N++ID ++ +LID+G H + Y +R + Sbjct: 148 VVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD-EPYTDFDGTRVYSP 206 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK 260 PE + +Q + +WSLG +L M+ PF Q+ + + Sbjct: 207 PEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHF-------------- 252 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 320 VSP+ L+ + L R + +E + Sbjct: 253 ------------------------------PAHVSPDCCALIRRCLAPKPSSRPSLEEIL 282 Query: 321 EHPYFYPVVKEQSQP 335 P+ + P Sbjct: 283 LDPWMQ--TPAEDVP 295 >2XYN-A nrPDB Length = 292 Score = 183 bits (465), Expect = 9e-47, Method: Composition-based stats. Identities = 44/236 (18%), Positives = 98/236 (41%), Gaps = 16/236 (6%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGTN 94 + D + KLG G+Y EV+ + + V VK LK ++ ++ +E +++ ++ N Sbjct: 31 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH-PN 89 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI-----RFYMYELLKALDYCH 149 +++L+ + +V EY+ + + ++ + ++ A++Y Sbjct: 90 LVQLLGVC--TLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 147 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVD 206 K +HRD+ N ++ + +++ D+GL+ Y +++ + PE L Sbjct: 148 KKNFIHRDLAARNCLVG-ENHVVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA- 204 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 Y + D+W+ G +L + + G D + K E+ G K Sbjct: 205 YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 260 >3IO7-A nrPDB Length = 313 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 54/294 (18%), Positives = 117/294 (39%), Gaps = 36/294 (12%) Query: 30 HVPSWGNQDDYQLVRKLGRGKYSEVFEAI----NITNNERVVVKILKPVKKK---KIKRE 82 ++ + + + +++LG+G + V E V VK L+ ++ +RE Sbjct: 21 NMTQFEER-HLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFERE 79 Query: 83 VKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDF----DIRFYM 138 ++IL++L+ NI+K + L+ EY+ + Q + + Y Sbjct: 80 IEILKSLQH-DNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYT 138 Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN----VRVA 194 ++ K ++Y +K +HRD+ N++++++ ++++ D+GL + +EY + Sbjct: 139 SQICKGMEYLGTKRYIHRDLATRNILVENEN-RVKIGDFGLTKVLPQDKEYYKVKEPGES 197 Query: 195 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-----RREP--FFHGQDNYDQLVRIA 247 ++ PE L + + + + D+WS G +L + + P F N Q I Sbjct: 198 PIFWYAPESLTESK-FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIV 256 Query: 248 KVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDL 301 L + + D + + W N ++ P DL Sbjct: 257 FHL----IELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQR------PSFRDL 300 >4C59-A nrPDB Length = 340 Score = 182 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 58/312 (18%), Positives = 118/312 (37%), Gaps = 72/312 (23%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIKREVKILENLRGGTNI 95 ++ R L G ++ V+EA ++ + +K L + K + I +EV ++ L G NI Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNI 87 Query: 96 IKL-----IDTVKDPVSKTPALVFEYINNTDFKQLYQI------LTDFDIRFYMYELLKA 144 ++ I + + L+ + + + L+ + Y+ +A Sbjct: 88 VQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRA 147 Query: 145 LDYCHSKG--IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN------------ 190 + + H + I+HRD+K N+++ + Q ++L D+G A +Y+ Sbjct: 148 VQHMHRQKPPIIHRDLKVENLLLSN-QGTIKLCDFGSATTISHYPDYSWSAQRRALVEEE 206 Query: 191 -VRVASRYFKGPELLVDYQMY--DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIA 247 R + ++ PE++ Y + D+W+LGC+L + FR+ PF G Sbjct: 207 ITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGA---------- 256 Query: 248 KVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLR 307 + + PH HS L+ +L+ Sbjct: 257 --------KLRIVNGKYSIPPHDTQYTVFHS----------------------LIRAMLQ 286 Query: 308 YDHQQRLTAKEA 319 + ++RL+ E Sbjct: 287 VNPEERLSIAEV 298 >4AT3-A nrPDB Length = 299 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 49/232 (21%), Positives = 99/232 (42%), Gaps = 33/232 (14%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINIT-----NNERVVVKILKPVK---KKKIKREVKILE 87 + + L R+LG G + +VF A + V VK LK +K RE ++L Sbjct: 11 KRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLT 70 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----------------LTD 131 NL+ +I+K + +VFEY+ + D + + LT Sbjct: 71 NLQH-EHIVKFYGVCVE--GDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQ 127 Query: 132 FDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV 191 + ++ + Y S+ +HRD+ N ++ + +++ D+G++ + Y V Sbjct: 128 SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG-ENLLVKIGDFGMSRDVYSTDYYRV 186 Query: 192 RVASR---YFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRREPFFHGQDN 239 + + PE ++ Y+ + D+WSLG +L + + ++P++ +N Sbjct: 187 GGHTMLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 237 >4H1J-A nrPDB Length = 293 Score = 182 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 53/263 (20%), Positives = 108/263 (41%), Gaps = 23/263 (8%) Query: 32 PSWG-NQDDYQLVRKLGRGKYSEVFEAI---NITNNERVVVKILKPV----KKKKIKREV 83 P +G ++D L R LG G + EV+E + + V VK K K+K E Sbjct: 17 PQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEA 76 Query: 84 KILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMY 139 I++NL +I+KLI +++ + ++ E + + L + Y Sbjct: 77 VIMKNL-DHPHIVKLIGIIEEEPT---WIIMELYPYGELGHYLERNKNSLKVLTLVLYSL 132 Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY-- 197 ++ KA+ Y S +HRD+ N+++ + ++L D+GL+ + Y V Sbjct: 133 QICKAMAYLESINCVHRDIAVRNILVASPEC-VKLGDFGLSRYIEDEDYYKASVTRLPIK 191 Query: 198 FKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRREPFF--HGQDNYDQLVRIAKVLGTEE 254 + PE + +++ + + D+W + ++ F ++PFF +D L + ++ + Sbjct: 192 WMSPESI-NFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDL 250 Query: 255 LYGYLKKYHIDLDPHFNDILGQH 277 L + + Sbjct: 251 CPPVLYTLMTRCWDYDPSDRPRF 273 >4E93-A nrPDB Length = 377 Score = 181 bits (459), Expect = 4e-46, Method: Composition-based stats. Identities = 53/225 (23%), Positives = 88/225 (39%), Gaps = 18/225 (8%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVK----ILKPVKKKKIKREVKILENLRG 91 N +D L ++GRG + EVF +N V VK L P K K +E +IL+ Sbjct: 112 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQY-S 170 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDY 147 NI++LI + +V E + DF + L + + + ++Y Sbjct: 171 HPNIVRLIGVCTQ--KQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEY 228 Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY----FKGPEL 203 SK +HRD+ N ++ + L++ D+G++ Y R + PE Sbjct: 229 LESKCCIHRDLAARNCLVTEKN-VLKISDFGMSREEADGV-YAASGGLRQVPVKWTAPEA 286 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 L +Y Y D+WS G +L + N + K Sbjct: 287 L-NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEK 330 >3LLT-A nrPDB Length = 360 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 64/330 (19%), Positives = 130/330 (39%), Gaps = 49/330 (14%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILENLRGGTNI-- 95 + ++RK+G G + V +I N + VK+++ +KK + K E IL+ ++ Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINNN 96 Query: 96 --IKLIDTVKDPVSKTPALVFEYINNTDFKQL----YQILTDFDIRFYMYELLKALDYCH 149 +K L+FE + + ++ + Y DI+ Y E+LKAL+Y Sbjct: 97 NIVKYHGKF--MYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLR 154 Query: 150 SKGIMHRDVKPHNVMID------------------------HQQKKLRLIDWGLAEFYHP 185 + H D+KP N+++D + ++LID+G A F Sbjct: 155 KMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSD 214 Query: 186 AQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR 245 + + +R ++ PE++++ +D S DMWS GC+LA + F ++ + L Sbjct: 215 --YHGSIINTRQYRAPEVILNL-GWDVSSDMWSFGCVLAELYTGSL-LFRTHEHMEHLAM 270 Query: 246 IAKVLGTEELYGYLKK---------YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSP 296 + ++ + +L + + + + + + Sbjct: 271 MESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKIIKHE 330 Query: 297 EALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 D L +L+ D R + E ++H + Sbjct: 331 LFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >2HK5-A nrPDB Length = 270 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 49/292 (16%), Positives = 116/292 (39%), Gaps = 37/292 (12%) Query: 21 SREYWDYEAHVPSWG-NQDDYQLVRKLGRGKYSEVFEA-INITNNERVVVKILKP--VKK 76 +++ W+ +A W ++ +L +KLG G++ EV+ A N +V VK +KP + Sbjct: 1 AQKPWEKDA----WEIPRESLKLEKKLGAGQFGEVWMATYNKHT--KVAVKTMKPGSMSV 54 Query: 77 KKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----ILTD 131 + E +++ L+ ++KL V + ++ E++ + Sbjct: 55 EAFLAEANVMKTLQHDK-LVKLHAVV---TKEPIYIITEFMAKGSLLDFLKSDEGSKQPL 110 Query: 132 FDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV 191 + + ++ + + + + +HRD++ N+++ ++ D+GLA EY Sbjct: 111 PKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASL-VCKIADFGLARVIED-NEYTA 168 Query: 192 RVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 R +++ + PE + ++ + D+WS G +L ++ + G N + + + + Sbjct: 169 REGAKFPIKWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALER 227 Query: 249 VLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300 Y + + + L + W+N LD Sbjct: 228 ------------GYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLD 267 >5X5O-A nrPDB Length = 310 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 52/204 (25%), Positives = 89/204 (43%), Gaps = 19/204 (9%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIK 97 DD Q G G + V+ A I+ ++ V VK L KI++E +IL L NII+ Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-----LKIEKEAEILSVL-SHRNIIQ 68 Query: 98 LIDTVKDPVSKTPALVFEYINNTDFKQLYQI-----LTDFDIRFYMYELLKALDYCHSK- 151 + +P +V EY + + I + ++ K + Y H + Sbjct: 69 FYGVILEP--PNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEA 126 Query: 152 --GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 209 ++HRD+K NV+I L++ D+G A +H + V + + PE++ + Sbjct: 127 PVKVIHRDLKSRNVVI-AADGVLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEVIQSLPV 184 Query: 210 YDYSLDMWSLGCMLASMIFRREPF 233 + D +S G +L M+ R PF Sbjct: 185 -SETCDTYSYGVVLWEMLTREVPF 207 >6FEX-A nrPDB Length = 321 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 62/327 (18%), Positives = 118/327 (36%), Gaps = 68/327 (20%) Query: 36 NQDDYQLVRKLGRGKYSEVFEA----------------INITNNERVVVKILKPVKKK-- 77 + + KLG G++ EV + + V VKIL+P K Sbjct: 14 PRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNA 73 Query: 78 --KIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD-- 133 +EVKI+ L+ NII+L+ ++ +Y+ N D Q D Sbjct: 74 RNDFLKEVKIMSRLKD-PNIIRLLGVC--VQDDPLCMITDYMENGDLNQFLSAHQLEDKA 130 Query: 134 --------------IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL 179 + ++ + Y + +HRD+ N ++ + +++ D+G+ Sbjct: 131 AEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG-ENFTIKIADFGM 189 Query: 180 AEFYHPAQEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS--MIFRREPFF 234 + + Y V+ V + E ++ + + D+W+ G L M+ R +PF Sbjct: 190 SRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRAQPF- 247 Query: 235 HGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLV 294 GQ +Q++ A E ++ ++ P L + + W SE R Sbjct: 248 -GQLTDEQVIENAG----EFFRDQGRQVYLSRPPACPQGLYELMLRCWSR--ESEQRPPF 300 Query: 295 SPEALDLLDKLLRYDHQQRLTAKEAME 321 S L + L A++A+ Sbjct: 301 SQ-----LHRFL---------AEDALN 313 >2RIO-A nrPDB Length = 434 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 57/321 (17%), Positives = 118/321 (36%), Gaps = 69/321 (21%) Query: 44 RKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVK 103 + LG G V V VK + E+K+L N+I+ Sbjct: 21 KILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYY--CS 77 Query: 104 DPVSKTPALVFEYINNT--DF-------KQLYQILTDFDIRFYMYELLKALDYCHSKGIM 154 + + + E N D + ++ +++ + ++ + + HS I+ Sbjct: 78 ETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKII 137 Query: 155 HRDVKPHNVMIDH------------QQKKLRLIDWGLAEFYHPAQ-----EYNVRVASRY 197 HRD+KP N+++ + ++ + D+GL + Q N + Sbjct: 138 HRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSG 197 Query: 198 FKGPELLVD------YQMYDYSLDMWSLGCMLASMIF-RREPFFHGQDNYDQLVRIAKVL 250 ++ PELL + + S+D++S+GC+ ++ + PF D Y + I + + Sbjct: 198 WRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF---GDKYSRESNIIRGI 254 Query: 251 GTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDH 310 + + L + + EA DL+ +++ +D Sbjct: 255 FSLDEMKCL------------------------------HDRSLIAEATDLISQMIDHDP 284 Query: 311 QQRLTAKEAMEHPYFYPVVKE 331 +R TA + + HP F+P K+ Sbjct: 285 LKRPTAMKVLRHPLFWPKSKK 305 >4JLC-A nrPDB Length = 657 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 49/251 (19%), Positives = 104/251 (41%), Gaps = 28/251 (11%) Query: 42 LVRKLGRGKYSEVFEAINITNNERVVVKI------LKPVKKKKIKREVKILENLRGGTNI 95 L LG+G + VF + + VK+ L+PV + RE ++L+ L NI Sbjct: 12 LSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 68 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ------ILTDFDIRFYMYELLKALDYCH 149 +KL ++ ++ L+ E+ + + L + + + +++ +++ Sbjct: 69 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 128 Query: 150 SKGIMHRDVKPHNVM--IDHQQKKL-RLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV- 205 GI+HRD+KP N+M I + + +L D+G A +++ + + P++ Sbjct: 129 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 188 Query: 206 ------DYQMYDYSLDMWSLGCMLASMIFRREPFFH---GQDNYDQLVRIAKVLGTEELY 256 + Y ++D+WS+G PF + N + + +I + + Sbjct: 189 AVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 248 Query: 257 GYLKKYHIDLD 267 G K + +D Sbjct: 249 GVQKAENGPID 259 >1FVR-A nrPDB Length = 327 Score = 177 bits (450), Expect = 5e-45, Method: Composition-based stats. Identities = 47/308 (15%), Positives = 104/308 (33%), Gaps = 65/308 (21%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERV--VVKILKPVKKKKIKR----EVKILENLRG 91 +D + +G G + +V +A + R+ +K +K K R E+++L L Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGH 84 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI-------------------LTDF 132 NII L+ + L EY + + + L+ Sbjct: 85 HPNIINLLGACEH--RGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQ 142 Query: 133 DIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR 192 + + ++ + +DY K +HRD+ N+++ + ++ D+GL+ + + Sbjct: 143 QLLHFAADVARGMDYLSQKQFIHRDLAARNILVG-ENYVAKIADFGLSRGQEVYVKKTMG 201 Query: 193 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT 252 + E L +Y +Y + D+WS G +L ++ + G + ++ + Sbjct: 202 RLPVRWMAIESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRL 260 Query: 253 EELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQ 312 E+ E DL+ + R + Sbjct: 261 EKPLN------------------------------------CDDEVYDLMRQCWREKPYE 284 Query: 313 RLTAKEAM 320 R + + + Sbjct: 285 RPSFAQIL 292 >3QGY-A nrPDB Length = 286 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 34/221 (15%), Positives = 92/221 (41%), Gaps = 16/221 (7%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGT 93 + + V+++G G++ V + N ++V +K +K + + E +++ L Sbjct: 25 DPSELTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIKEGSMSEDDFIEEAEVMMKL-SHP 82 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCH 149 +++L + LVFE++ + + + ++ + + Y Sbjct: 83 KLVQLYGVCLEQA--PICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLE 140 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVD 206 ++HRD+ N ++ + + +++ D+G+ F Q Y +++ + PE+ Sbjct: 141 EACVIHRDLAARNCLVG-ENQVIKVSDFGMTRFVLDDQ-YTSSTGTKFPVKWASPEVF-S 197 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIA 247 + Y D+WS G ++ + + + + N + + I+ Sbjct: 198 FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDIS 238 >1AD5-A nrPDB Length = 438 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 48/295 (16%), Positives = 115/295 (38%), Gaps = 47/295 (15%) Query: 18 SLRSREYWDYEAHVPSWG-NQDDYQLVRKLGRGKYSEVFEA-INITNNERVVVKILKP-- 73 S + ++ W+ +A W ++ +L +KLG G++ EV+ A N +V VK +KP Sbjct: 165 SSKPQKPWEKDA----WEIPRESLKLEKKLGAGQFGEVWMATYNKHT--KVAVKTMKPGS 218 Query: 74 VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----I 128 + + E +++ L+ ++KL V + ++ E++ + Sbjct: 219 MSVEAFLAEANVMKTLQHDK-LVKLHAVV---TKEPIYIITEFMAKGSLLDFLKSDEGSK 274 Query: 129 LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE 188 + + ++ + + + + +HRD++ N+++ ++ D+GLA Sbjct: 275 QPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASL-VCKIADFGLAR------- 326 Query: 189 YNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR 245 V +++ + PE + ++ + D+WS G +L ++ + G N + + Sbjct: 327 ----VGAKFPIKWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRA 381 Query: 246 IAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300 + + Y + + + L + W+N LD Sbjct: 382 LER------------GYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLD 424 >5B2L-A nrPDB Length = 324 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 50/308 (16%), Positives = 119/308 (38%), Gaps = 51/308 (16%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK----PVKKKKIKREVKILENLRGGT 93 +D + + ++G G +V++ + VK ++ + K+I ++ ++ Sbjct: 17 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 76 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL----TDFDIRFYMYELLKALDYC- 148 I++ T + + E + T ++L + + + + ++KAL Y Sbjct: 77 YIVQCFGTF--ITNTDVFIAMELM-GTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLK 133 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV--- 205 G++HRDVKP N+++D ++ +++L D+G++ ++ + PE + Sbjct: 134 EKHGVIHRDVKPSNILLD-ERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPD 192 Query: 206 -DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 YD D+WSLG L + + P+ + + +++ L ++ + Sbjct: 193 PTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ---------------- 236 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324 + P +G S + + L DH++R + +EH + Sbjct: 237 EEPPLLPGHMG------------------FSGDFQSFVKDCLTKDHRKRPKYNKLLEHSF 278 Query: 325 FYPVVKEQ 332 + Sbjct: 279 IKRYETLE 286 >5AMN-A nrPDB Length = 299 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 58/306 (18%), Positives = 124/306 (40%), Gaps = 48/306 (15%) Query: 30 HVPSWG-NQDDYQLVRKLGRGKYSEVFEAINITNNER-----VVVKILK----PVKKKKI 79 P W + + L + LG G++ +V +A R V VK+LK P + + + Sbjct: 14 EDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDL 73 Query: 80 KREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ------------ 127 E +L+ + ++IKL L+ EY + + Sbjct: 74 LSEFNVLKQV-NHPHVIKLYGACSQ--DGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDE 130 Query: 128 -ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA 186 LT D+ + +++ + + Y ++HRD+ N+++ + +K+++ D+GL+ + Sbjct: 131 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEE 189 Query: 187 QEYNVRVASR---YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQL 243 Y R R + E L D+ +Y D+WS G +L ++ + G Sbjct: 190 DSYVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPG------- 241 Query: 244 VRIAKVLGTEELYGYLKKYH-IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLL 302 + E L+ LK H ++ + ++ + + + W+ + R + + + DL Sbjct: 242 ------IPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQ--EPDKRPVFADISKDL- 292 Query: 303 DKLLRY 308 +K++ Sbjct: 293 EKMMVK 298 >4EUU-A nrPDB Length = 319 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 47/251 (18%), Positives = 104/251 (41%), Gaps = 28/251 (11%) Query: 42 LVRKLGRGKYSEVFEAINITNNERVVVKI------LKPVKKKKIKREVKILENLRGGTNI 95 L LG+G + VF + + +K+ L+PV + RE ++L+ L NI Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 69 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI------LTDFDIRFYMYELLKALDYCH 149 +KL ++ ++ L+ E+ + + L + + + +++ +++ Sbjct: 70 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 129 Query: 150 SKGIMHRDVKPHNVM--IDHQQKKL-RLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV- 205 GI+HR++KP N+M I + + +L D+G A +++ + + P++ Sbjct: 130 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 189 Query: 206 ------DYQMYDYSLDMWSLGCMLASMIFRREPFFH---GQDNYDQLVRIAKVLGTEELY 256 + Y ++D+WS+G PF + N + + +I + + Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 249 Query: 257 GYLKKYHIDLD 267 G K + +D Sbjct: 250 GVQKAENGPID 260 >6BSD-A nrPDB Length = 876 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 62/333 (18%), Positives = 118/333 (35%), Gaps = 74/333 (22%) Query: 36 NQDDYQLVRKLGRGKYSEVFEA----------------INITNNERVVVKILKPVKKK-- 77 + + KLG G++ EV + + V VKIL+P K Sbjct: 569 PRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNA 628 Query: 78 --KIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD-- 133 +EVKI+ L+ NII+L+ ++ +Y+ N D Q D Sbjct: 629 RNDFLKEVKIMSRLKD-PNIIRLLGVC--VQDDPLCMITDYMENGDLNQFLSAHQLEDKA 685 Query: 134 --------------------IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLR 173 + ++ + Y + +HRD+ N ++ + ++ Sbjct: 686 AEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG-ENFTIK 744 Query: 174 LIDWGLAEFYHPAQEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS--MIF 228 + D+G++ + Y V+ V + E ++ + + D+W+ G L M+ Sbjct: 745 IADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLC 803 Query: 229 RREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHS 288 R +PF GQ +Q++ A E ++ ++ P L + + W S Sbjct: 804 RAQPF--GQLTDEQVIENAG----EFFRDQGRQVYLSRPPACPQGLYELMLRCWSR--ES 855 Query: 289 ENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 E R S L + L A++A+ Sbjct: 856 EQRPPFSQ-----LHRFL---------AEDALN 874 >4M7I-A nrPDB Length = 299 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 49/273 (17%), Positives = 108/273 (39%), Gaps = 39/273 (14%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK----PVKKKKIKREVKILENLRGGTN 94 D++ ++ LGRG + VFEA N ++ +K ++ + ++K+ REVK L L Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEH-PG 64 Query: 95 IIKLIDTVKDPVSK----------TPALVFEYINNTDFKQLYQILTDFDIR------FYM 138 I++ + + + + + + K + R Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124 Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE---------- 188 ++ +A+++ HSKG+MHRD+KP N+ +++ D+GL +E Sbjct: 125 LQIAEAVEFLHSKGLMHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPA 183 Query: 189 ---YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR 245 + +V ++ + PE + Y + +D++SLG +L +++ PF + L Sbjct: 184 YARHTGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFELLY---PFSTQMERVRTLTD 239 Query: 246 IAKVLGTEELYGYLKKYHIDLDPHFNDILGQHS 278 + + ++ + + + Sbjct: 240 VRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERP 272 >2VWV-A nrPDB Length = 302 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 51/289 (17%), Positives = 109/289 (37%), Gaps = 40/289 (13%) Query: 41 QLVRKLGRGKYSEVFEAINITNNER---VVVKILK----PVKKKKIKREVKILENLRGGT 93 ++ +G G++ EV ++ V +K LK ++++ E I+ Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEH-P 77 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCH 149 NII+L V + S ++ E++ N ++ T + + + + Y Sbjct: 78 NIIRLEGVVTN--SMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLA 135 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH---PAQEYNVRVASR---YFKGPEL 203 +HRD+ N++++ ++ D+GL+ F + + + PE Sbjct: 136 EMSYVHRDLAARNILVNS-NLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEA 194 Query: 204 LVDYQMYDYSLDMWSLGCMLAS-MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 + ++ + + D WS G ++ M F P++ N D + I + Y Sbjct: 195 IA-FRKFTSASDAWSYGIVMWEVMSFGERPYW-DMSNQDVINAIEQ------------DY 240 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQ 311 + P L Q W+ ++ R P+ + LDK++R + Sbjct: 241 RLPPPPDCPTSLHQLMLDCWQKDRNARPRF---PQVVSALDKMIR-NPA 285 >5VO2-A nrPDB Length = 300 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 46/280 (16%), Positives = 101/280 (36%), Gaps = 50/280 (17%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDP 105 +G G VF + E V VK ++ +K+ IK L L+ NII Sbjct: 20 VGSGAQGAVFLGR--FHGEEVAVKKVRDLKETDIKH----LRKLKH-PNIITFKGVCTQ- 71 Query: 106 VSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHN 162 + ++ E+ ++ + +T + + + ++Y H I+HRD+K N Sbjct: 72 -APCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPN 130 Query: 163 VMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCM 222 ++I + +++ D+G ++ + + PE++ + + +D+WS G + Sbjct: 131 MLITYDD-VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRN-EPVSEKVDIWSFGVV 188 Query: 223 LASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRW 282 L ++ P+ + I +G+ L H+ + D R+ W Sbjct: 189 LWELLTGEIPYKDVDSSA-----IIWGVGSNSL-------HLPVPSSCPDGFKILLRQCW 236 Query: 283 ENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322 + + R + ++ + H Sbjct: 237 NSK------------------------PRNRPSFRQILLH 252 >2PMN-X nrPDB Length = 348 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 69/333 (20%), Positives = 139/333 (41%), Gaps = 68/333 (20%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV--------------------KKK 77 +DY+++R L +GK++++ +N+ +K + K Sbjct: 31 NDYRIIRTLNQGKFNKIILCEK--DNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYD 88 Query: 78 KIKREVKILENLRG-----GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDF 132 K E++I+ +++ II D +++EY+ N + + Sbjct: 89 DFKNELQIITDIKNEYCLTCEGIITNYD--------EVYIIYEYMENDSILKFDEYFFVL 140 Query: 133 D-----------IRFYMYELLKALDYCH-SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180 D I+ + +L + Y H K I HRDVKP N+++D + +++L D+G + Sbjct: 141 DKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMD-KNGRVKLSDFGES 199 Query: 181 EFYHPAQEYNVRVASRYFKGPELLVDYQMY-DYSLDMWSLGCMLASMIFRREPFFHGQDN 239 E+ ++ + F PE + Y +D+WSLG L M + PF Sbjct: 200 EYMVD-KKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFS----- 253 Query: 240 YDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEAL 299 ++I+ V EL+ ++ +I+ N L + K+ + + + +S E + Sbjct: 254 ----LKISLV----ELFNNIRTKNIEYPLDRNHFLYPLTNKK-----STCSNNFLSNEDI 300 Query: 300 DLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ 332 D L LR + +R+T+++A++H + E Sbjct: 301 DFLKLFLRKNPAERITSEDALKHEWLADTNIED 333 >2R2P-A nrPDB Length = 295 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 58/287 (20%), Positives = 106/287 (36%), Gaps = 38/287 (13%) Query: 41 QLVRKLGRGKYSEVFEAINITNNER---VVVKILKPVKKKKIKR----EVKILENLRGGT 93 + R +G G++ EV +R V +K LK +K +R E I+ Sbjct: 25 TIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQF-DHP 83 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCH 149 NII L V SK +V EY+ N + T + + + + Y Sbjct: 84 NIIHLEGVV--TKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLS 141 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE--YNVRVA--SRYFKGPELLV 205 G +HRD+ N++I+ ++ D+GL+ E Y R + PE + Sbjct: 142 DMGYVHRDLAARNILINS-NLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA 200 Query: 206 DYQMYDYSLDMWSLGCMLASMI-FRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 ++ + + D+WS G ++ ++ + P++ N D + + + Y + Sbjct: 201 -FRKFTSASDVWSYGIVMWEVVSYGERPYWE-MTNQDVIKAVEE------------GYRL 246 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQ 311 L Q W+ N E +++LDK L + Sbjct: 247 PSPMDCPAALYQLMLDCWQK---ERNSRPKFDEIVNMLDK-LIRNPA 289 >4EUT-A nrPDB Length = 396 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 47/251 (18%), Positives = 104/251 (41%), Gaps = 28/251 (11%) Query: 42 LVRKLGRGKYSEVFEAINITNNERVVVKI------LKPVKKKKIKREVKILENLRGGTNI 95 L LG+G + VF + + +K+ L+PV + RE ++L+ L NI Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 69 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI------LTDFDIRFYMYELLKALDYCH 149 +KL ++ ++ L+ E+ + + L + + + +++ +++ Sbjct: 70 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 129 Query: 150 SKGIMHRDVKPHNVM--IDHQQKKL-RLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV- 205 GI+HR++KP N+M I + + +L D+G A +++ + + P++ Sbjct: 130 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 189 Query: 206 ------DYQMYDYSLDMWSLGCMLASMIFRREPFFH---GQDNYDQLVRIAKVLGTEELY 256 + Y ++D+WS+G PF + N + + +I + + Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 249 Query: 257 GYLKKYHIDLD 267 G K + +D Sbjct: 250 GVQKAENGPID 260 >3DKO-A nrPDB Length = 318 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 53/287 (18%), Positives = 105/287 (36%), Gaps = 38/287 (13%) Query: 41 QLVRKLGRGKYSEVFEAINITNNER---VVVKILKPVKKKKIKR----EVKILENLRGGT 93 ++ R +G G++ EV +R V +K LK +K +R E I+ Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQF-DHP 104 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCH 149 N++ L V K +V E++ N + T + + + + Y Sbjct: 105 NVVHLEGVVTR--GKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLA 162 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE--YNVRVA--SRYFKGPELLV 205 G +HRD+ N++++ ++ D+GL+ E Y + PE + Sbjct: 163 DMGYVHRDLAARNILVNS-NLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAI- 220 Query: 206 DYQMYDYSLDMWSLGCMLAS-MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 Y+ + + D+WS G ++ M + P++ N D + I + Y + Sbjct: 221 QYRKFTSASDVWSYGIVMWEVMSYGERPYW-DMSNQDVIKAIEE------------GYRL 267 Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQ 311 L Q W+ + + + +LDK++R + Sbjct: 268 PAPMDCPAGLHQLMLDCWQKERAERPKF---EQIVGILDKMIR-NPN 310 >4P5Q-A nrPDB Length = 361 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 58/285 (20%), Positives = 106/285 (37%), Gaps = 38/285 (13%) Query: 42 LVRKLGRGKYSEVFEAINITNNER---VVVKILKPVKKKKIKR----EVKILENLRGGTN 94 + + +G G++ EV +++ V +K LK +K +R E I+ N Sbjct: 37 IDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQF-DHPN 95 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCHS 150 II+L V SK +V EY+ N + T + + + + Y Sbjct: 96 IIRLEGVV--TKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSD 153 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE--YNVRVA--SRYFKGPELLVD 206 G +HRD+ N++I+ ++ D+GL+ E Y R + PE + Sbjct: 154 MGYVHRDLAARNILINS-NLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA- 211 Query: 207 YQMYDYSLDMWSLGCMLAS-MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 Y+ + + D+WS G +L M + P++ N D + + + Y + Sbjct: 212 YRKFTSASDVWSYGIVLWEVMSYGERPYWE-MSNQDVIKAVDE------------GYRLP 258 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDH 310 L Q W+ N + + +LDK L + Sbjct: 259 PPMDCPAALYQLMLDCWQK---DRNNRPKFEQIVSILDK-LIRNP 299 >2Y6O-A nrPDB Length = 291 Score = 175 bits (443), Expect = 4e-44, Method: Composition-based stats. Identities = 44/255 (17%), Positives = 91/255 (35%), Gaps = 22/255 (8%) Query: 41 QLVRKLGRGKYSEVFEAINITNNER---VVVKILK----PVKKKKIKREVKILENLRGGT 93 ++ + +G G++ EV +R V +K LK +++ E I+ Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQF-DHP 75 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCH 149 NII L V K ++ EY+ N + T + + + + Y Sbjct: 76 NIIHLEGVV--TKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLS 133 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE--YNVRVA--SRYFKGPELLV 205 +HRD+ N++++ ++ D+G++ E Y R + PE + Sbjct: 134 DMSYVHRDLAARNILVNS-NLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA 192 Query: 206 DYQMYDYSLDMWSLGCMLAS-MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHI 264 Y+ + + D+WS G ++ M + P++ N D + I + H Sbjct: 193 -YRKFTSASDVWSYGIVMWEVMSYGERPYW-DMSNQDVIKAIEEGYRLPPPMDCPIALHQ 250 Query: 265 DLDPHFNDILGQHSR 279 + + + Sbjct: 251 LMLDCWQKERSDRPK 265 >2A1A-B nrPDB Length = 284 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 55/275 (20%), Positives = 109/275 (39%), Gaps = 25/275 (9%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKL 98 D++ + +G G + +VF+A + + + V+K +K +K +REVK L L NI+ Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK-YNNEKAEREVKALAKL-DHVNIVHY 69 Query: 99 IDTVK--------------DPVSKTPALVFEYINNTDFKQLYQI-----LTDFDIRFYMY 139 +K + E+ + +Q + L Sbjct: 70 NGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFE 129 Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK 199 ++ K +DY HSK +++RD+KP N+ + K++++ D+GL + + + Sbjct: 130 QITKGVDYIHSKKLINRDLKPSNIFL-VDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYM 188 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR--IAKVLGTEELYG 257 PE + Q Y +D+++LG +LA ++ + F + L I+ + +E Sbjct: 189 SPEQI-SSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTL 247 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRH 292 K + N + W+ RH Sbjct: 248 LQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERH 282 >5HLW-A nrPDB Length = 299 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 51/254 (20%), Positives = 106/254 (41%), Gaps = 23/254 (9%) Query: 44 RKLGRGKYSEVFEAINITNNER---VVVKILKPV----KKKKIKREVKILENLRGGTNII 96 +GRG + V+ + N+ + VK L + + + E I+++ N++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF-SHPNVL 84 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTD----FDIRFYMYELLKALDYCHSKG 152 L+ +P +V Y+ + D + + T D+ + ++ K + Y SK Sbjct: 85 SLLGICLRS-EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKK 143 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVAS-----RYFKGPELLVDY 207 +HRD+ N M+D ++ +++ D+GLA H + Y+V + + E L Sbjct: 144 FVHRDLAARNCMLD-EKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQ-T 201 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQ---LVRIAKVLGTEELYGYLKKYHI 264 Q + D+WS G +L ++ R P + + +D L++ ++L E L + + Sbjct: 202 QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVML 261 Query: 265 DLDPHFNDILGQHS 278 ++ S Sbjct: 262 KCWHPKAEMRPSFS 275 >5KMM-A nrPDB Length = 329 Score = 173 bits (440), Expect = 7e-44, Method: Composition-based stats. Identities = 50/305 (16%), Positives = 108/305 (35%), Gaps = 72/305 (23%) Query: 45 KLGRGKYSEVFEAINIT-----NNERVVVKILKPVK---KKKIKREVKILENLRGGTNII 96 +LG G + +VF A + V VK LK ++ +RE ++L L+ +I+ Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQ-HIV 100 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQ------------------ILTDFDIRFYM 138 + + + +VFEY+ + D + + L + Sbjct: 101 RFFGVCTE--GRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVA 158 Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASR-- 196 ++ + Y +HRD+ N ++ Q +++ D+G++ + Y V + Sbjct: 159 SQVAAGMVYLAGLHFVHRDLATRNCLVG-QGLVVKIGDFGMSRDIYSTDYYRVGGRTMLP 217 Query: 197 -YFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRREPFFHGQDNYDQLVRIAKVLGTEE 254 + PE ++ Y+ + D+WS G +L + + ++P++ N + + I + E Sbjct: 218 IRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQ-LSNTEAIDCITQGRELER 275 Query: 255 LYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL 314 PE ++ + + QQR Sbjct: 276 P------------------------------------RACPPEVYAIMRGCWQREPQQRH 299 Query: 315 TAKEA 319 + K+ Sbjct: 300 SIKDV 304 >5MJB-A nrPDB Length = 305 Score = 173 bits (439), Expect = 9e-44, Method: Composition-based stats. Identities = 53/289 (18%), Positives = 110/289 (38%), Gaps = 40/289 (13%) Query: 41 QLVRKLGRGKYSEVFEAINITNNER---VVVKILK----PVKKKKIKREVKILENLRGGT 93 ++ +G G++ EV++ +R V +K LK +++ E I+ Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQF-DHR 87 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCH 149 NII+L V S+ ++ E++ N + T + + + + Y Sbjct: 88 NIIRLEGVV--TKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLS 145 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP---AQEYNVRVASR---YFKGPEL 203 +HRD+ N++++ ++ D+GL+ + Y + + + PE Sbjct: 146 EMNYVHRDLAARNILVNS-NLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEA 204 Query: 204 LVDYQMYDYSLDMWSLGCMLAS-MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 + Y+ + + D+WS G ++ M F P++ N D + I + Y Sbjct: 205 IA-YRKFTSASDVWSYGIVMWEVMSFGERPYW-DMSNQDVINAIEQ------------DY 250 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQ 311 + L Q W+ +S R E ++ LDK++R + Sbjct: 251 RLPPPMDCPAALHQLMLDCWQKDRNSRPRF---AEIVNTLDKMIR-NPA 295 >6NT9-A nrPDB Length = 742 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 47/251 (18%), Positives = 104/251 (41%), Gaps = 28/251 (11%) Query: 42 LVRKLGRGKYSEVFEAINITNNERVVVKI------LKPVKKKKIKREVKILENLRGGTNI 95 L LG+G + VF + + +K+ L+PV + RE ++L+ L NI Sbjct: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 67 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI------LTDFDIRFYMYELLKALDYCH 149 +KL ++ ++ L+ E+ + + L + + + +++ +++ Sbjct: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 Query: 150 SKGIMHRDVKPHNVM--IDHQQKKL-RLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV- 205 GI+HR++KP N+M I + + +L D+G A +++ + + P++ Sbjct: 128 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYER 187 Query: 206 ------DYQMYDYSLDMWSLGCMLASMIFRREPFFH---GQDNYDQLVRIAKVLGTEELY 256 + Y ++D+WS+G PF + N + + +I + + Sbjct: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 247 Query: 257 GYLKKYHIDLD 267 G K + +D Sbjct: 248 GVQKAENGPID 258 >2WTK-B nrPDB Length = 373 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 62/340 (18%), Positives = 120/340 (35%), Gaps = 37/340 (10%) Query: 40 YQLVRKLGRGKYS---EVFEAINITNNERVVVKILKPVKKKK-----IKREVKILENLRG 91 Y+L+ +G+G + V A E V V+ + ++ E+ + L Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHV-SKLFN 68 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-----QILTDFDIRFYMYELLKALD 146 NI+ T +V ++ K L + + I + + +LKALD Sbjct: 69 HPNIVPYRATF--IADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALD 126 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQK--------KLRLIDWGLA-EFYHPAQEYNVRVASRY 197 Y H G +HR VK +++I K L +I G H +Y+V+V Sbjct: 127 YIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKV--LP 184 Query: 198 FKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY 256 + PE+L + Q YD D++S+G + PF L ++ + Sbjct: 185 WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDT 244 Query: 257 GYLKKYHIDLDPHFN--------DILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRY 308 + + + P + + R + SP +++ L+ Sbjct: 245 STIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQR 304 Query: 309 DHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTA 348 + R +A + H +F + + S+ + + +T Sbjct: 305 NPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITN 344 >6O8B-A nrPDB Length = 665 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 47/251 (18%), Positives = 104/251 (41%), Gaps = 28/251 (11%) Query: 42 LVRKLGRGKYSEVFEAINITNNERVVVKI------LKPVKKKKIKREVKILENLRGGTNI 95 L LG+G + VF + + +K+ L+PV + RE ++L+ L NI Sbjct: 19 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKL-NHKNI 75 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ------ILTDFDIRFYMYELLKALDYCH 149 +KL ++ ++ L+ E+ + + L + + + +++ +++ Sbjct: 76 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 135 Query: 150 SKGIMHRDVKPHNVM--IDHQQKKL-RLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV- 205 GI+HR++KP N+M I + + +L D+G A +++ + + P++ Sbjct: 136 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYER 195 Query: 206 ------DYQMYDYSLDMWSLGCMLASMIFRREPFFH---GQDNYDQLVRIAKVLGTEELY 256 + Y ++D+WS+G PF + N + + +I + + Sbjct: 196 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAIS 255 Query: 257 GYLKKYHIDLD 267 G K + +D Sbjct: 256 GVQKAENGPID 266 >5VD3-A nrPDB Length = 311 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 65/310 (20%), Positives = 113/310 (36%), Gaps = 54/310 (17%) Query: 27 YEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-----PVKKKKIKR 81 Y+ P Q +Q + +LG G Y EVF+ + + VK P + + Sbjct: 46 YDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLA 105 Query: 82 EVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFY 137 EV E + ++L ++ L E +Q + L + + Y Sbjct: 106 EVGSHEKVGQHPCCVRLEQAWEE--GGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGY 162 Query: 138 MYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY 197 + + L AL + HS+G++H DVKP N+ + + + +L D+GL A V+ Sbjct: 163 LRDTLLALAHLHSQGLVHLDVKPANIFLG-PRGRCKLGDFGLLVELGTAGAGEVQEGDPR 221 Query: 198 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 + PELL Y + D++SLG + + E HG + + QL + Sbjct: 222 YMAPELLQGS--YGTAADVFSLGLTILEVACNME-LPHGGEGWQQLRQ------------ 266 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317 ++ E +S E +L +L D + R TA+ Sbjct: 267 --------------------------GYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAE 300 Query: 318 EAMEHPYFYP 327 + P Sbjct: 301 ALLALPVLRQ 310 >5L6P-A nrPDB Length = 298 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 44/274 (16%), Positives = 106/274 (38%), Gaps = 26/274 (9%) Query: 41 QLVRKLGRGKYSEVFEAINITNNER---VVVKILK----PVKKKKIKREVKILENLRGGT 93 ++ +G G++ EV R V +K LK +++ E I+ Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQF-DHP 80 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCH 149 NII+L V S+ ++ E++ N ++ T + + + + Y Sbjct: 81 NIIRLEGVV--TKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLS 138 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP---AQEYNVRVASR---YFKGPEL 203 +HRD+ N++++ ++ D+GL+ F Y + + + PE Sbjct: 139 EMNYVHRDLAARNILVNS-NLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEA 197 Query: 204 LVDYQMYDYSLDMWSLGCMLAS-MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 + Y+ + + D+WS G ++ M + P++ N D + + + Sbjct: 198 IA-YRKFTSASDVWSYGIVMWEVMSYGERPYW-DMSNQDVINAVEQDYRLPPPMDCPTAL 255 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSP 296 H + + + ++ R ++ +++ ++ + +P Sbjct: 256 HQLMLDCW--VRDRNLRPKFSQIVNTLDKLIRNP 287 >4IDT-A nrPDB Length = 356 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 48/204 (23%), Positives = 83/204 (40%), Gaps = 18/204 (8%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKD 104 +LGRG + EV + + VK ++ + E+ L I+ L V++ Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRA--EELMACAGLTS-PRIVPLYGAVRE 137 Query: 105 PVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPH 161 + E + QL + L + +Y+ + L+ L+Y HS+ I+H DVK Sbjct: 138 --GPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKAD 195 Query: 162 NVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV------ASRYFKGPELLVDYQMYDYSLD 215 NV++ L D+G A P + + PE+++ + D +D Sbjct: 196 NVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG-RSCDAKVD 254 Query: 216 MWSLGCMLASMIFRREP---FFHG 236 +WS CM+ M+ P FF G Sbjct: 255 VWSSCCMMLHMLNGCHPWTQFFRG 278 >1K9A-A nrPDB Length = 450 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 52/311 (16%), Positives = 110/311 (35%), Gaps = 59/311 (18%) Query: 22 REYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-KKIK 80 E++ + N + +L++ +G+G++ +V +V VK +K + Sbjct: 181 DEFYRSGWAL----NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFL 234 Query: 81 REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIR 135 E ++ LR N+++L+ + + +V EY+ + +L + Sbjct: 235 AEASVMTQLRHS-NLVQLLGVIVEE-KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 Query: 136 FYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVAS 195 + ++ +A++Y +HRD+ NV++ + ++ D+GL + Q+ Sbjct: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTGKL--P 349 Query: 196 RYFKGPELLVDYQMYDYSLDMWSLGCMLASM-IFRREPFFHGQDNYDQLVRIAKVLGTEE 254 + PE L + + + D+WS G +L + F R P+ Sbjct: 350 VKWTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPY--------------------- 387 Query: 255 LYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL 314 I + R E + P D++ D R Sbjct: 388 ----------------PRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRP 431 Query: 315 T---AKEAMEH 322 T +E +EH Sbjct: 432 TFLQLREQLEH 442 >3KUL-B nrPDB Length = 325 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 54/306 (17%), Positives = 108/306 (35%), Gaps = 26/306 (8%) Query: 8 SRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNER-- 65 + YAE ++ E + + +G G EV +R Sbjct: 21 PEPQFYAEPHT--YEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDV 78 Query: 66 -VVVKILK----PVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 120 V +K LK +++ E I+ NII+L V + +V EY+ N Sbjct: 79 PVAIKALKAGYTERQRRDFLSEASIMGQF-DHPNIIRLEGVVTR--GRLAMIVTEYMENG 135 Query: 121 DFKQLYQI----LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLID 176 + T + + + + Y G +HRD+ NV++D ++ D Sbjct: 136 SLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDS-NLVCKVSD 194 Query: 177 WGLAEFYHPAQE--YNVRVA--SRYFKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRRE 231 +GL+ + Y + PE + ++ + + D+WS G ++ + + Sbjct: 195 FGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIA-FRTFSSASDVWSFGVVMWEVLAYGER 253 Query: 232 PFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENR 291 P+++ N D + + + G H + ++ Q R R+ + + Sbjct: 254 PYWN-MTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQ--RPRFSQIVSVLDA 310 Query: 292 HLVSPE 297 + SPE Sbjct: 311 LIRSPE 316 >3BBT-B nrPDB Length = 328 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 54/301 (17%), Positives = 117/301 (38%), Gaps = 36/301 (11%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERV----VVKILK----PVKKKKIKREVKILE 87 + + + V+ LG G + V++ I + E V +KIL P + E I+ Sbjct: 13 KETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMA 72 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTD----FDIRFYMYELLK 143 ++ ++++L+ P T LV + + + + D + + ++ K Sbjct: 73 SM-DHPHLVRLLGVCLSP---TIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAK 128 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKG 200 + Y + ++HRD+ NV++ +++ D+GLA ++ + + Sbjct: 129 GMMYLEERRLVHRDLAARNVLVKSPN-HVKITDFGLARLLEGDEKEYNADGGKMPIKWMA 187 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIF-RREPF--FHGQDNYDQLVRIAKVLGTEEL-- 255 E + Y+ + + D+WS G + ++ +P+ ++ D L + ++ Sbjct: 188 LECI-HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTI 246 Query: 256 ---YGYLKKYHIDLD--PHFNDILGQHSRK-----RWENFIHSENRHLVSPEALDLLDKL 305 +K + ID D P F ++ + SR R+ + L SP L Sbjct: 247 DVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNL 306 Query: 306 L 306 L Sbjct: 307 L 307 >1JPA-A nrPDB Length = 312 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 44/274 (16%), Positives = 104/274 (37%), Gaps = 26/274 (9%) Query: 41 QLVRKLGRGKYSEVFEAINITNNER---VVVKILKP----VKKKKIKREVKILENLRGGT 93 ++ + +G G++ EV +R V +K LK +++ E I+ Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQF-DHP 94 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCH 149 N+I L V S ++ E++ N + T + + + + Y Sbjct: 95 NVIHLEGVV--TKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLA 152 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP---AQEYNVRVASR---YFKGPEL 203 +HRD+ N++++ ++ D+GL+ F Y + + + PE Sbjct: 153 DMNYVHRDLAARNILVNS-NLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEA 211 Query: 204 LVDYQMYDYSLDMWSLGCMLAS-MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 + Y+ + + D+WS G ++ M + P++ N D + I + Sbjct: 212 I-QYRKFTSASDVWSYGIVMWEVMSYGERPYW-DMTNQDVINAIEQDYRLPPPMDCPSAL 269 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSP 296 H + + ++ R ++ +++ ++ + +P Sbjct: 270 HQLMLDCWQK--DRNHRPKFGQIVNTLDKMIRNP 301 >6E4F-A nrPDB Length = 290 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 44/253 (17%), Positives = 107/253 (42%), Gaps = 16/253 (6%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGT 93 + D +++LG G++ V V +K++K + + + E K++ NL Sbjct: 29 DPKDLTFLKELGTGQFGVVKYGKWR-GQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEK 87 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDF----DIRFYMYELLKALDYCH 149 +++L + ++ EY+ N + + + ++ +A++Y Sbjct: 88 -LVQLYGVCTKQ--RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE 144 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVD 206 SK +HRD+ N +++ Q +++ D+GL+ + EY V S++ + PE+L+ Sbjct: 145 SKQFLHRDLAARNCLVN-DQGVVKVSDFGLSRYV-LDDEYTSSVGSKFPVRWSPPEVLM- 201 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 Y + D+W+ G ++ + + + N + IA+ L + +K + + Sbjct: 202 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIM 261 Query: 267 DPHFNDILGQHSR 279 +++ + Sbjct: 262 YSCWHEKADERPT 274 >1BYG-A nrPDB Length = 278 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 45/268 (16%), Positives = 105/268 (39%), Gaps = 32/268 (11%) Query: 22 REYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK-KKIK 80 E++ + N + +L++ +G+G++ +V +V VK +K + Sbjct: 9 DEFYRSGWAL----NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFL 62 Query: 81 REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIR 135 E ++ LR N+++L+ + + +V EY+ + +L + Sbjct: 63 AEASVMTQLRHS-NLVQLLGVIVEE-KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 120 Query: 136 FYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVAS 195 + ++ +A++Y +HRD+ NV++ + ++ D+GL + Q+ Sbjct: 121 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVS-EDNVAKVSDFGLTKEASSTQDTGKL--P 177 Query: 196 RYFKGPELLVDYQMYDYSLDMWSLGCMLASM-IFRREPFFHGQDNYDQLVRIAKVLGTEE 254 + PE L + + + D+WS G +L + F R P+ ++ + Sbjct: 178 VKWTAPEALRE-KKFSTKSDVWSFGILLWEIYSFGRVPY-------------PRIPLKDV 223 Query: 255 LYGYLKKYHIDLDPHFNDILGQHSRKRW 282 + K Y +D + + + W Sbjct: 224 VPRVEKGYKMDAPDGCPPAVYEVMKNCW 251 >3UIU-A nrPDB Length = 306 Score = 171 bits (433), Expect = 4e-43, Method: Composition-based stats. Identities = 57/290 (19%), Positives = 111/290 (38%), Gaps = 38/290 (13%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKL 98 D++ + +G G + +VF+A + + + V++ +K +K +REVK L L NI+ Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVK-YNNEKAEREVKALAKL-DHVNIVHY 70 Query: 99 IDTV------------------KDPVS---------KTPALVFEYINNTDFKQLY----- 126 DP + K + E+ + +Q Sbjct: 71 NGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRG 130 Query: 127 QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA 186 + L ++ K +DY HSK ++HRD+KP N+ + K++++ D+GL Sbjct: 131 EKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFL-VDTKQVKIGDFGLVTSLKND 189 Query: 187 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR- 245 + + + PE + Q Y +D+++LG +LA ++ + F + L Sbjct: 190 GKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDG 248 Query: 246 -IAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLV 294 I+ + +E K + N + W+ RH Sbjct: 249 IISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC 298 >5FM2-A nrPDB Length = 355 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 58/320 (18%), Positives = 124/320 (38%), Gaps = 62/320 (19%) Query: 30 HVPSWG-NQDDYQLVRKLGRGKYSEVFEAINITNNER-----VVVKILK----PVKKKKI 79 P W + + L + LG G++ +V +A R V VK+LK P + + + Sbjct: 55 EDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDL 114 Query: 80 KREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ------------ 127 E +L+ + ++IKL L+ EY + + Sbjct: 115 LSEFNVLKQV-NHPHVIKLYGACSQ--DGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGS 171 Query: 128 ---------------ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL 172 LT D+ + +++ + + Y ++HRD+ N+++ + +K+ Sbjct: 172 GGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKM 230 Query: 173 RLIDWGLAEFYHPAQEYNVRVASR---YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR 229 ++ D+GL+ + Y R R + E L D+ +Y D+WS G +L ++ Sbjct: 231 KISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTL 289 Query: 230 REPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH-IDLDPHFNDILGQHSRKRWENFIHS 288 + G + E L+ LK H ++ + ++ + + + W+ Sbjct: 290 GGNPYPG-------------IPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQ--EP 334 Query: 289 ENRHLVSPEALDLLDKLLRY 308 + R + + + DL +K++ Sbjct: 335 DKRPVFADISKDL-EKMMVK 353 >4XI2-A nrPDB Length = 446 Score = 170 bits (432), Expect = 6e-43, Method: Composition-based stats. Identities = 42/253 (16%), Positives = 107/253 (42%), Gaps = 16/253 (6%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGT 93 + D +++LG G++ V V +K+++ + + + E K++ NL Sbjct: 185 DPKDLTFLKELGTGQFGVVKYGKWR-GQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEK 243 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDF----DIRFYMYELLKALDYCH 149 +++L + ++ EY+ N + + + ++ +A++Y Sbjct: 244 -LVQLYGVCTKQ--RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE 300 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVD 206 SK +HRD+ N +++ Q +++ D+GL+ + EY V S++ + PE+L+ Sbjct: 301 SKQFLHRDLAARNCLVN-DQGVVKVSDFGLSRYV-LDDEYTSSVGSKFPVRWSPPEVLM- 357 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 Y + D+W+ G ++ + + + N + IA+ L + ++ + + Sbjct: 358 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIM 417 Query: 267 DPHFNDILGQHSR 279 +++ + Sbjct: 418 YSCWHEKADERPS 430 >3SXS-A nrPDB Length = 268 Score = 170 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 37/222 (16%), Positives = 95/222 (42%), Gaps = 16/222 (7%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGT 93 +++ L+++LG G++ V V VK++K + + + +E + + L Sbjct: 6 KREEITLLKELGSGQFGVVKLGKWK-GQYDVAVKMIKEGSMSEDEFFQEAQTMMKL-SHP 63 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCH 149 ++K +V EYI+N + L + Y++ + + + Sbjct: 64 KLVKFYGVCSKEY--PIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLE 121 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVD 206 S +HRD+ N ++D +++ D+G+ + Q Y V +++ + PE+ Sbjct: 122 SHQFIHRDLAARNCLVDRDLC-VKVSDFGMTRYVLDDQ-YVSSVGTKFPVKWSAPEVFHY 179 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 ++ Y D+W+ G ++ + + + N + ++++++ Sbjct: 180 FK-YSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQ 220 >6B2Q-A nrPDB Length = 317 Score = 170 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 49/224 (21%), Positives = 99/224 (44%), Gaps = 17/224 (7%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVKILENLRGG 92 Y+L R + G +V+EA++ RV VK+LK P ++ + E + L Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML-NH 91 Query: 93 TNIIKLIDTVKDPVS---KTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALD 146 I + D + ++ +T LV E +N + + L+ + + +AL Sbjct: 92 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 151 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH--PAQEYNVRVASRYFKGPELL 204 H+ G++HRDVKP N++I ++++ D+G+A+ P + + + + + PE Sbjct: 152 IAHAAGLVHRDVKPGNILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 210 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 + + + D++SLG + + + PF + I + Sbjct: 211 LGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 253 >4X3F-A nrPDB Length = 337 Score = 170 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 49/224 (21%), Positives = 99/224 (44%), Gaps = 17/224 (7%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVKILENLRGG 92 Y+L R + G +V+EA++ RV VK+LK P ++ + E + L Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML-NH 71 Query: 93 TNIIKLIDTVKDPVS---KTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALD 146 I + D + ++ +T LV E +N + + L+ + + +AL Sbjct: 72 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 131 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH--PAQEYNVRVASRYFKGPELL 204 H+ G++HRDVKP N++I ++++ D+G+A+ P + + + + + PE Sbjct: 132 IAHAAGLVHRDVKPGNILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 190 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 + + + D++SLG + + + PF + I + Sbjct: 191 LGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 233 >4OW8-A nrPDB Length = 283 Score = 170 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 49/224 (21%), Positives = 99/224 (44%), Gaps = 17/224 (7%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVKILENLRGG 92 Y+L R + G +V+EA++ RV VK+LK P ++ + E + L Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML-NH 70 Query: 93 TNIIKLIDTVKDPVS---KTPALVFEYINNTDFKQLYQI---LTDFDIRFYMYELLKALD 146 I + D + ++ +T LV E +N + + L+ + + +AL Sbjct: 71 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 130 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH--PAQEYNVRVASRYFKGPELL 204 H+ G++HRDVKP N++I ++++ D+G+A+ P + + + + + PE Sbjct: 131 IAHAAGLVHRDVKPGNILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 189 Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 + + + D++SLG + + + PF + I + Sbjct: 190 LGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 232 >4Y93-A nrPDB Length = 446 Score = 170 bits (431), Expect = 9e-43, Method: Composition-based stats. Identities = 41/253 (16%), Positives = 105/253 (41%), Gaps = 16/253 (6%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK--PVKKKKIKREVKILENLRGGT 93 + D +++LG G++ V V +K++K + + + E K++ NL Sbjct: 186 DPKDLTFLKELGTGQFGVVKYGKWR-GQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEK 244 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDF----DIRFYMYELLKALDYCH 149 +++L + ++ EY+ N + + + ++ +A++Y Sbjct: 245 -LVQLYGVCTKQ--RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLE 301 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---FKGPELLVD 206 SK +HRD+ N +++ Q +++ D+G+ + EY S++ + PE+L+ Sbjct: 302 SKQFLHRDLAARNCLVN-DQGVVKVSDFGMTRYV-LDDEYTSSTGSKFPVKWASPEVLM- 358 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266 Y + D+W+ G ++ + + + N + IA+ L + ++ + + Sbjct: 359 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAIM 418 Query: 267 DPHFNDILGQHSR 279 +++ + Sbjct: 419 YSCWHEKADERPT 431 >3C1X-A nrPDB Length = 373 Score = 170 bits (430), Expect = 9e-43, Method: Composition-based stats. Identities = 49/261 (18%), Positives = 113/261 (43%), Gaps = 30/261 (11%) Query: 44 RKLGRGKYSEVFEAINITNNER---VVVKILKPV----KKKKIKREVKILENLRGGTNII 96 +GRG + V+ + N+ + VK L + + + E I+++ N++ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF-SHPNVL 153 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTD----FDIRFYMYELLKALDYCHSKG 152 L+ +P +V Y+ + D + + T D+ + ++ K + + SK Sbjct: 154 SLLGICLRS-EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKK 212 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ--EYNVRVASRY---FKGPELLVDY 207 +HRD+ N M+D ++ +++ D+GLA + + + + ++ + E L Sbjct: 213 FVHRDLAARNCMLD-EKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQ-T 270 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQ---LVRIAKVLGTEELYGYLKKYHI 264 Q + D+WS G +L ++ R P + + +D L++ ++L E L + + Sbjct: 271 QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVML 330 Query: 265 -------DLDPHFNDILGQHS 278 ++ P F++++ + S Sbjct: 331 KCWHPKAEMRPSFSELVSRIS 351 >6CTH-A nrPDB Length = 309 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 60/247 (24%), Positives = 108/247 (43%), Gaps = 21/247 (8%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK---REVKILENLRGGTNI 95 ++ KLG G + V+ ++ + VK + K+ IK EVKI+ LR N+ Sbjct: 16 NFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRH-KNL 74 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRF-YMYELLKALDYCHSK 151 +KLI + LV+E++ N + L +++R+ + +L AL Y H + Sbjct: 75 VKLIGWCHE--RGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEE 132 Query: 152 G---IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ--EYNVRVASRYFKGPELLVD 206 G ++HRD+K N+M+D +L D+GLA A+ + + + + PE L Sbjct: 133 GDHCVLHRDIKTSNIMLDSSFNA-KLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSS 191 Query: 207 YQMYDYSLDMWSLGCMLASMIFRR---EPFFHGQDNYDQLVRIAKVLGTEELYGYL-KKY 262 + D++S G + + R EP F + + + + G E + +K Sbjct: 192 GKA-SKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADRKL 250 Query: 263 HIDLDPH 269 + DP Sbjct: 251 GMAFDPK 257 >4Y83-A nrPDB Length = 332 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 56/289 (19%), Positives = 113/289 (39%), Gaps = 43/289 (14%) Query: 48 RGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVS 107 RG + +V+ A +I +R+ K++ + K E++ NI +L V Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQA---CFRHENIAELYGAVL--WG 137 Query: 108 KTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVM 164 +T L E + + + +F+I + +LK LD+ HSK ++H D+KP N++ Sbjct: 138 ETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIV 197 Query: 165 IDHQQKKLRLIDWGLAEFYHPAQEY-NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 223 + L+D+GL+ + + + PE+++ + + D++SLG L Sbjct: 198 FMSTKAV--LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL-CRGHSTKADIYSLGATL 254 Query: 224 ASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWE 283 M P+ +K+Y P + I+ + + Sbjct: 255 IHMQTGTPPW-------------------------VKRYPRSAYPSYLYIIHKQAPP--- 286 Query: 284 NFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQ 332 + SP +L++ L + R A + ++H P ++Q Sbjct: 287 ---LEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALNPPREDQ 332 >4PDO-A nrPDB Length = 299 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 41/234 (17%), Positives = 91/234 (38%), Gaps = 23/234 (9%) Query: 41 QLVRKLGRGKYSEVFEAINITNNER----VVVKILKPVKKKK----IKREVKILENLRGG 92 + +G G++ EV++ + T++ + V +K LK +K E I+ Sbjct: 37 TRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHH 96 Query: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYC 148 NII+L + K ++ EY+ N + + + + + + + Y Sbjct: 97 -NIIRLEGVI--SKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYL 153 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE--YNVRVA--SRYFKGPELL 204 + +HRD+ N++++ ++ D+GL+ E Y + PE + Sbjct: 154 ANMNYVHRDLAARNILVNS-NLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAI 212 Query: 205 VDYQMYDYSLDMWSLGCMLAS-MIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 Y+ + + D+WS G ++ M + P++ N++ + I Sbjct: 213 -SYRKFTSASDVWSFGIVMWEVMTYGERPYWE-LSNHEVMKAINDGFRLPTPMD 264 >4YFF-A nrPDB Length = 311 Score = 168 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 42/209 (20%), Positives = 82/209 (39%), Gaps = 19/209 (9%) Query: 41 QLVRKLGRGKYSEVFEAINITNNERVVVKI------LKPVKKKKIKREVKILENLRGGTN 94 + +G G + +V++ N+ V +K REV IL L Sbjct: 45 EFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQL-NHPC 101 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKALDYCH- 149 +I+ + + S+ A+V +YI+ L IL ++ K ++Y H Sbjct: 102 VIQFVGACLNDPSQ-FAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHN 160 Query: 150 -SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH--PAQEYNVRVASRYFKGPELLVD 206 ++ I+HRD+ HN+++ ++ + D+G + F + + + PE+ Sbjct: 161 LTQPIIHRDLNSHNILL-YEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQ 219 Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFH 235 Y D++S L ++ PF H Sbjct: 220 CTRYTIKADVFSYALCLWEILTGEIPFAH 248 >3PP0-A nrPDB Length = 338 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 57/303 (18%), Positives = 125/303 (41%), Gaps = 35/303 (11%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERV----VVKILK----PVKKKKIKREVKILE 87 + + + V+ LG G + V++ I I + E V +K+L+ P K+I E ++ Sbjct: 15 KETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMA 74 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLK 143 + G + +L+ ++ T LV + + + L D+ + ++ K Sbjct: 75 GV-GSPYVSRLLGIC---LTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAK 130 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVA--SRYFKG 200 + Y ++HRD+ NV++ +++ D+GLA EY+ + Sbjct: 131 GMSYLEDVRLVHRDLAARNVLVKSPN-HVKITDFGLARLLDIDETEYHADGGKVPIKWMA 189 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIF-RREPF--FHGQDNYDQLVRIAKV----LGTE 253 E ++ + + + D+WS G + ++ +P+ ++ D L + ++ + T Sbjct: 190 LESIL-RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTI 248 Query: 254 ELYGYLKKYHI---DLDPHFNDILGQHSRKRWEN----FIHSENRHLVSPEALDLLDKLL 306 ++Y + K + + P F +++ + SR + I +E+ SP LL Sbjct: 249 DVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLL 308 Query: 307 RYD 309 D Sbjct: 309 EDD 311 >1LUF-A nrPDB Length = 343 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 48/260 (18%), Positives = 96/260 (36%), Gaps = 46/260 (17%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAIN-----ITNNERVVVKILKPVK----KKKIKREVKIL 86 +++ + VR +G G + VF+A V VK+LK + +RE ++ Sbjct: 45 PRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALM 104 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI------------ 134 NI+KL+ V K L+FEY+ D + + ++ + Sbjct: 105 AEFDN-PNIVKLLGVC--AVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRA 161 Query: 135 ---------------RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL 179 ++ + Y + +HRD+ N ++ + +++ D+GL Sbjct: 162 RVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVG-ENMVVKIADFGL 220 Query: 180 AEFYHPAQEYNVRVA---SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI-FRREPFFH 235 + + A Y + PE + Y Y D+W+ G +L + + +P++ Sbjct: 221 SRNIYSADYYKADGNDAIPIRWMPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQPYYG 279 Query: 236 -GQDNYDQLVRIAKVLGTEE 254 + VR +L E Sbjct: 280 MAHEEVIYYVRDGNILACPE 299 >4G3E-A nrPDB Length = 352 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 43/198 (21%), Positives = 86/198 (43%), Gaps = 15/198 (7%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKD 104 ++GRG + EV + + VK ++ ++ +++ E+ L I+ L V++ Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVR-LEVFRVE-ELVACAGLSS-PRIVPLYGAVRE 137 Query: 105 PVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPH 161 + E + QL + L + +Y+ + L+ L+Y H++ I+H DVK Sbjct: 138 --GPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKAD 195 Query: 162 NVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV------ASRYFKGPELLVDYQMYDYSLD 215 NV++ + L D+G A P + + PE+++ + D +D Sbjct: 196 NVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-KPCDAKVD 254 Query: 216 MWSLGCMLASMIFRREPF 233 +WS CM+ M+ P+ Sbjct: 255 IWSSCCMMLHMLNGCHPW 272 >1U59-A nrPDB Length = 287 Score = 167 bits (422), Expect = 8e-42, Method: Composition-based stats. Identities = 44/253 (17%), Positives = 102/253 (40%), Gaps = 34/253 (13%) Query: 45 KLGRGKYSEVFEAINITNNER--VVVKILK----PVKKKKIKREVKILENLRGGTNIIKL 98 +LG G + V + + ++ V +K+LK +++ RE +I+ L I++L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN-PYIVRL 75 Query: 99 IDTVKDPVSKTPALVFEYINNTDFKQLY----QILTDFDIRFYMYELLKALDYCHSKGIM 154 I + ++ LV E + + + ++ ++++ + Y K + Sbjct: 76 IGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 132 Query: 155 HRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRY---FKGPELLVDYQMY 210 HRD+ NV++ + ++ D+GL++ Y R A ++ + PE + +++ + Sbjct: 133 HRDLAARNVLL-VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKF 190 Query: 211 DYSLDMWSLGCMLAS-MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 D+WS G + + + ++P+ K+ G E + + ++ P Sbjct: 191 SSRSDVWSYGVTMWEALSYGQKPY-------------KKMKGPEVMAFIEQGKRMECPPE 237 Query: 270 FNDILGQHSRKRW 282 L W Sbjct: 238 CPPELYALMSDCW 250 >6FER-A nrPDB Length = 309 Score = 167 bits (422), Expect = 8e-42, Method: Composition-based stats. Identities = 50/282 (17%), Positives = 102/282 (36%), Gaps = 47/282 (16%) Query: 40 YQLVRKLGRGKYSEVFEAI--------------NITNNE--RVVVKILKPVKKK----KI 79 KLG G++ EV +++ N+ V VK+L+ K Sbjct: 11 LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDF 70 Query: 80 KREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY------------- 126 +E+KI+ L+ NII L+ ++ EY+ N D Q Sbjct: 71 LKEIKIMSRLKD-PNIIHLLAVC--ITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDV 127 Query: 127 QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA 186 + ++ +++F ++ + Y S +HRD+ N ++ + +++ D+G++ + Sbjct: 128 RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVG-KNYTIKIADFGMSRNLYSG 186 Query: 187 QEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQL 243 Y ++ V + E ++ + + D+W+ G L F + Y QL Sbjct: 187 DYYRIQGRAVLPIRWMSWESIL-LGKFTTASDVWAFGVTLWETFT-----FCQEQPYSQL 240 Query: 244 VRIAKVLGTEELYGYLKKYHIDLDPH-FNDILGQHSRKRWEN 284 + T E + + P D + + W Sbjct: 241 SDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRR 282 >5HVK-A nrPDB Length = 315 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 42/207 (20%), Positives = 88/207 (42%), Gaps = 27/207 (13%) Query: 43 VRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK---IKREVKILENLRGGTNIIKLI 99 LG+G + + + + E +V+K L ++ +EVK++ L N++K I Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEH-PNVLKFI 77 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLYQILTDF----DIRFYMYELLKALDYCHSKGIMH 155 + K + EYI + + + + + ++ + Y HS I+H Sbjct: 78 GVLYK--DKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 135 Query: 156 RDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA---------------QEYNVRVASRYFKG 200 R++ HN ++ + K + + D+GLA ++ V + Y+ Sbjct: 136 RNLNSHNCLV-RENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMA 194 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMI 227 PE++ + + YD +D++S G +L +I Sbjct: 195 PEMI-NGRSYDEKVDVFSFGIVLCEII 220 >4LQP-A nrPDB Length = 508 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 69/345 (20%), Positives = 131/345 (37%), Gaps = 67/345 (19%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL------KPVKKKKIKREVKILENLRG 91 +D+ V+ +G+G + EV + +K L K + +K E +L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAG-SD 160 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYC 148 ++ L + +D ++ L+ E++ D + Q+ T+ RFYM E + A++ Sbjct: 161 SPWVVSLYYSFQD--AQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETI 218 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK-------GP 201 H G +HR +KP N++ID + ++L D+GL+ +H + N Y+K Sbjct: 219 HKLGFIHRAIKPDNILIDIR-GHIKLSDFGLSTGFHKTHDSN------YYKKLLQQDEAT 271 Query: 202 ELLVDYQMYDYS------------LDMWSLGCMLASMIFRREP-----------FFHGQD 238 + Y+ + +D SL +M R++ + Sbjct: 272 NGISKPGTYNANTTDTANKRQTMVVDSISL-----TMSNRQQIQTWRKSRRLMAYSTVGT 326 Query: 239 NYDQLVRIA--KVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSE------N 290 I + G E + L + + + ++ + ++ E + Sbjct: 327 PDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPD 386 Query: 291 RHLVSPEALDLLDKLLRYDHQQRL----TAKEAMEHPYFYPVVKE 331 +S EA DL+ +LL + QRL A E HP+F V Sbjct: 387 DIHISYEAEDLIRRLLTH-ADQRLGRHGGADEIKSHPFFRGVDWN 430 >3Q4U-A nrPDB Length = 301 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 59/311 (18%), Positives = 106/311 (34%), Gaps = 62/311 (19%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLR-GGTNIIK 97 D L+ +G+G+Y EV+ E V VKI +K RE ++ + NI+ Sbjct: 9 DITLLECVGKGRYGEVWRGSW--QGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILG 66 Query: 98 LI--DTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIR--FYMYELLKALDYCH---- 149 I D S L+ Y Q+ T + + + L + H Sbjct: 67 FIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF 126 Query: 150 ----SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-----YNVRVASRYFKG 200 I HRD+K N+++ + + + D GLA + + N RV ++ + Sbjct: 127 GTQGKPAIAHRDLKSKNILV-KKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMA 185 Query: 201 PELLVDYQMYD-----YSLDMWSLGCMLASMIFR----------REPFFHGQDNYDQLVR 245 PE+L + D +D+W+ G +L + R + PF+ N Sbjct: 186 PEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFED 245 Query: 246 IAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKL 305 + KV+ ++ + ++ A L+ + Sbjct: 246 MRKVVCVDQQRPNIPNRWFS-------------------------DPTLTSLAK-LMKEC 279 Query: 306 LRYDHQQRLTA 316 + RLTA Sbjct: 280 WYQNPSARLTA 290 >2BUJ-A nrPDB Length = 317 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 63/333 (18%), Positives = 124/333 (37%), Gaps = 68/333 (20%) Query: 21 SREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL---KPVKKK 77 RE ++ H+ N+ Y ++KLG G +S V + + +K + + ++ Sbjct: 13 GRENLYFQGHMVIIDNK-HYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDRE 71 Query: 78 KIKREVKILENLRGGTNIIKLIDTV--KDPVSKTPALVFEYINNTDF-------KQLYQI 128 + +RE + L NI++L+ + L+ + K Sbjct: 72 EAQREAD-MHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNF 130 Query: 129 LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL--------- 179 LT+ I + + + + L+ H+KG HRD+KP N+++ + + + L+D G Sbjct: 131 LTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPV-LMDLGSMNQACIHVE 189 Query: 180 -AEFYHPAQEYNVRVASRYFKGPEL--LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHG 236 + Q++ + + ++ PEL + + + D D+WSLGC+L +M+F P+ Sbjct: 190 GSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY--- 246 Query: 237 QDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSP 296 G +N + S Sbjct: 247 --------------------------------DMVFQKGDSVALAVQNQLSIPQSPRHSS 274 Query: 297 EALDLLDKLLRYDHQQR------LTAKEAMEHP 323 LL+ ++ D QR L+ EA++ P Sbjct: 275 ALWQLLNSMMTVDPHQRPHIPLLLSQLEALQPP 307 >5TE0-A nrPDB Length = 347 Score = 164 bits (416), Expect = 4e-41, Method: Composition-based stats. Identities = 57/327 (17%), Positives = 115/327 (35%), Gaps = 71/327 (21%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIKREVKILENLRGGT 93 + + L G ++ VF +N + +K + + KRE++I+ +L G Sbjct: 18 RQQVTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHK 76 Query: 94 NIIKLIDTVKDPVSKT----PALVFEYINNTDFKQLYQI-----LTDFDIRFYMYELLKA 144 NI+ ID+ + VS ++ ++ L T+ ++ + +A Sbjct: 77 NIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEA 136 Query: 145 LDYCHSKG--IMHRDVKPHNVMIDHQQKKLRLIDWGLA--EFYHPAQEYNVRV------- 193 + H I+HRD+K N+++ H + L D+G A +F +P E V Sbjct: 137 VARLHQCKTPIIHRDLKVENILL-HDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKY 195 Query: 194 ASRYFKGPEL--LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG 251 + ++ PE+ L ++ D+W+LGC+L + + PF Sbjct: 196 TTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF------------------ 237 Query: 252 TEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQ 311 G+ + + S + L+ +L D Sbjct: 238 -----------------------GESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPD 274 Query: 312 QRLTAKEAMEHPYFYPVVKEQSQPCAD 338 +R + YF + ++ P + Sbjct: 275 KRPDIYQV---SYFSFKLLKKECPIPN 298 >5GNK-A nrPDB Length = 297 Score = 164 bits (416), Expect = 4e-41, Method: Composition-based stats. Identities = 49/292 (16%), Positives = 118/292 (40%), Gaps = 37/292 (12%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERV----VVKILK----PVKKKKIKREVKILE 87 + +++ ++ LG G + V++ + I E+V +K L+ P K+I E ++ Sbjct: 17 KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMA 76 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMY----ELLK 143 ++ ++ +L+ ++ T L+ + + + D Y+ ++ K Sbjct: 77 SVDN-PHVCRLLGIC---LTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 132 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVA--SRYFKG 200 ++Y + ++HRD+ NV++ Q +++ D+GLA+ +EY+ + Sbjct: 133 GMNYLEDRRLVHRDLAARNVLVKTPQ-HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 191 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK 260 E ++ +++Y + D+WS G + ++ + G + +E K Sbjct: 192 LESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDG------------IPASEISSILEK 238 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQ 312 + P + K W I +++R ++ K+ D Q+ Sbjct: 239 GERLPQPPICTIDVYMIMVKCW--MIDADSRPKFRELIIEF-SKM-ARDPQR 286 >2OZO-A nrPDB Length = 613 Score = 164 bits (416), Expect = 4e-41, Method: Composition-based stats. Identities = 48/295 (16%), Positives = 112/295 (37%), Gaps = 39/295 (13%) Query: 4 PAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVR-KLGRGKYSEVFEAINITN 62 P E E D + + +D+ + +LG G + V + + Sbjct: 305 PRPMPMDTSVFESPFSDPEELKDKKL----FLKRDNLLIADIELGCGNFGSVRQGVYRMR 360 Query: 63 NER--VVVKILK----PVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEY 116 ++ V +K+LK +++ RE +I+ L I++LI + ++ LV E Sbjct: 361 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN-PYIVRLIGVCQ---AEALMLVMEM 416 Query: 117 INNTDFKQLY----QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL 172 + + + ++ ++++ + Y K +HR++ NV++ + Sbjct: 417 AGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLL-VNRHYA 475 Query: 173 RLIDWGLAEFYH-PAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLAS-MI 227 ++ D+GL++ Y R A ++ + PE + +++ + D+WS G + + Sbjct: 476 KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFSSRSDVWSYGVTMWEALS 534 Query: 228 FRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRW 282 + ++P+ K+ G E + + ++ P L W Sbjct: 535 YGQKPY-------------KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCW 576 >3LZB-A nrPDB Length = 327 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 50/292 (17%), Positives = 119/292 (40%), Gaps = 37/292 (12%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERV----VVKILK----PVKKKKIKREVKILE 87 + +++ ++ LG G + V++ + I E+V +K L+ P K+I E ++ Sbjct: 13 KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMA 72 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMY----ELLK 143 ++ ++ +L+ ++ T L+ + + + D Y+ ++ K Sbjct: 73 SVDN-PHVCRLLGIC---LTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 128 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVA--SRYFKG 200 ++Y + ++HRD+ NV++ Q +++ D+GLA+ +EY+ + Sbjct: 129 GMNYLEDRRLVHRDLAARNVLVKTPQ-HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 187 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK 260 E ++ +++Y + D+WS G + ++ + G + +E K Sbjct: 188 LESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDG------------IPASEISSILEK 234 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQ 312 + P + RK W I +++R ++ K+ D Q+ Sbjct: 235 GERLPQPPICTIDVYMIMRKCW--MIDADSRPKFRELIIEF-SKM-ARDPQR 282 >4TPT-A nrPDB Length = 303 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 47/212 (22%), Positives = 89/212 (41%), Gaps = 32/212 (15%) Query: 43 VRKLGRGKYSEVFEAINITNNERVVVKIL---KPVKKKKIKREVKILENLRGGTNIIKLI 99 LG+G + + + + + +V+K L +K EVK++ +L N++K I Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSL-DHPNVLKFI 63 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLYQILTDF---DIRFYMYELLKALDYCHSKGIMHR 156 + K L+ EYI K + + F + + + Y HS I+HR Sbjct: 64 GVLYK--DKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHR 121 Query: 157 DVKPHNVMIDHQQKKLRLIDWGLAEFY---------------------HPAQEYNVRVAS 195 D+ HN +I K + + D+GL+ + ++ V + Sbjct: 122 DLNSHNCLIKL-DKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 180 Query: 196 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMI 227 Y+ PE+L + + YD ++D++S G +L +I Sbjct: 181 PYWMAPEML-NGKSYDETVDIFSFGIVLCEII 211 >3ZBF-A nrPDB Length = 322 Score = 164 bits (415), Expect = 5e-41, Method: Composition-based stats. Identities = 47/247 (19%), Positives = 93/247 (37%), Gaps = 31/247 (12%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINIT-----NNE-RVVVKILKP----VKKKKIKREVKI 85 ++ L LG G + EV+E + + E +V VK LK +K + +E + Sbjct: 31 PREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHL 90 Query: 86 LENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----------LTDFDIR 135 + NI+K + +++ ++ E + D + LT D+ Sbjct: 91 MSKF-NHPNILKQLGVCL--LNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLV 147 Query: 136 FYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ----KKLRLIDWGLAEFYHPAQEYNV 191 ++ K Y +HRD+ N ++ + + +++ D+GLA + Y Sbjct: 148 DLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK 207 Query: 192 RV---ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 R + PE L+D ++ D+WS G ++ ++ + N D L + Sbjct: 208 RGEGLLPVRWMAPESLMD-GIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQT 266 Query: 249 VLGTEEL 255 E Sbjct: 267 GGRLEPP 273 >3QUP-A nrPDB Length = 323 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 52/304 (17%), Positives = 108/304 (35%), Gaps = 63/304 (20%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNE---RVVVKILK-----PVKKKKIKREVKILE 87 + + L R LG+G++ V EA + +V VK+LK ++ RE ++ Sbjct: 21 PEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMK 80 Query: 88 NLRGGTNIIKLIDTVKDPVSKT----PALVFEYINNTDFKQLYQI---------LTDFDI 134 ++ KL+ +K P ++ ++ + D L + Sbjct: 81 EF-DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTL 139 Query: 135 RFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVA 194 +M ++ ++Y S+ +HRD+ N M+ + + + D+GL+ + Y A Sbjct: 140 VRFMVDIACGMEYLSSRNFIHRDLAARNCML-AEDMTVCVADFGLSRKIYSGDYYRQGCA 198 Query: 195 SRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG 251 S+ + E L D +Y D+W+ G + ++ R + + G +N + + Sbjct: 199 SKLPVKWLALESLAD-NLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYL----- 252 Query: 252 TEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQ 311 + + P E DL+ + D + Sbjct: 253 -------IGGNRLKQPPECM------------------------EEVYDLMYQCWSADPK 281 Query: 312 QRLT 315 QR + Sbjct: 282 QRPS 285 >3PLS-A nrPDB Length = 298 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 51/256 (19%), Positives = 105/256 (41%), Gaps = 32/256 (12%) Query: 44 RKLGRGKYSEVFEAINITNNE---RVVVKILKPV----KKKKIKREVKILENLRGGTNII 96 R +G+G + V+ I + + +K L + + + RE ++ L N++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGL-NHPNVL 85 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL----TDFDIRFYMYELLKALDYCHSKG 152 LI + P P ++ Y+ + D Q + T D+ + ++ + ++Y + Sbjct: 86 ALIGIML-PPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144 Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR-----VASRYFKGPELLVDY 207 +HRD+ N M+D + +++ D+GLA + Y+V+ + E L Y Sbjct: 145 FVHRDLAARNCMLD-ESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTY 203 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 + + D+WS G +L ++ R P + D +D +A+ + Sbjct: 204 R-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQ------------P 250 Query: 268 PHFNDILGQHSRKRWE 283 + D L Q ++ WE Sbjct: 251 EYCPDSLYQVMQQCWE 266 >3I81-A nrPDB Length = 315 Score = 163 bits (414), Expect = 7e-41, Method: Composition-based stats. Identities = 53/336 (15%), Positives = 116/336 (34%), Gaps = 74/336 (22%) Query: 28 EAHVPS-WGN-QDDYQLVRKLGRGKYSEVFEAINI-----TNNERVVVKILKPV----KK 76 + +VP W ++ + R+LG+G + V+E + RV +K + ++ Sbjct: 6 DVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRER 65 Query: 77 KKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDF---- 132 + E +++ ++++L+ V + ++ E + D K + L Sbjct: 66 IEFLNEASVMKEFNCH-HVVRLLGVVSQ--GQPTLVIMELMTRGDLKSYLRSLRPEMENN 122 Query: 133 ---------DIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY 183 + E+ + Y ++ +HRD+ N M+ + +++ D+G+ Sbjct: 123 PVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV-AEDFTVKIGDFGMTRDI 181 Query: 184 HPAQEYNVRVA---SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240 + Y + PE L D ++ D+WS G +L + E + G N Sbjct: 182 YETDYYRKGGKGLLPVRWMSPESLKD-GVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNE 240 Query: 241 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300 L + + +D + D+L + R W Sbjct: 241 QVLRFVME------------GGLLDKPDNCPDMLFELMRMCW------------------ 270 Query: 301 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPC 336 +Y+ + R + E +KE+ +P Sbjct: 271 ------QYNPKMRPSFLE------IISSIKEEMEPG 294 >3MY0-A nrPDB Length = 305 Score = 163 bits (413), Expect = 9e-41, Method: Composition-based stats. Identities = 67/309 (21%), Positives = 107/309 (34%), Gaps = 64/309 (20%) Query: 42 LVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILEN-LRGGTNIIKLI- 99 LV +G+G+Y EV+ + + E V VKI ++ RE +I L NI+ I Sbjct: 12 LVECVGKGRYGEVWRGLW--HGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA 69 Query: 100 -DTVKDPVSKTPALVFEYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCH------- 149 D S L+ Y + Q L L + H Sbjct: 70 SDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQ 129 Query: 150 -SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY-----NVRVASRYFKGPEL 203 I HRD K NV++ + + D GLA + +Y N RV ++ + PE+ Sbjct: 130 GKPAIAHRDFKSRNVLVKSNLQCC-IADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEV 188 Query: 204 LVD------YQMYDYSLDMWSLGCMLASMIFR----------REPFFHGQDNYDQLVRIA 247 L + ++ Y D+W+ G +L + R R PF+ N + Sbjct: 189 LDEQIRTDCFESY-KWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMK 247 Query: 248 KVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLR 307 KV+ ++ + + DP + L Q R+ W Sbjct: 248 KVVCVDQQTPTIPN-RLAADPVLSG-LAQMMRECWYP----------------------- 282 Query: 308 YDHQQRLTA 316 + RLTA Sbjct: 283 -NPSARLTA 290 >4HZS-A nrPDB Length = 341 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 53/263 (20%), Positives = 99/263 (37%), Gaps = 29/263 (11%) Query: 37 QDDYQLVRKLGRGKYSEVFEAI-NITNNERV--VVKILKP------VKKKKIKREVKILE 87 + D +L+ KLG G + V + + + V VK LKP REV + Sbjct: 11 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMH 70 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLK 143 +L N+I+L V P K +V E + + Y ++ + Sbjct: 71 SL-DHRNLIRLYGVVLTPPMK---MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAE 126 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV----RVASRYFK 199 + Y SK +HRD+ N+++ + +++ D+GL ++ V R + Sbjct: 127 GMGYLESKRFIHRDLAARNLLLATRD-LVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWC 185 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMI-FRREPFFHGQDNYDQLVRI----AKVLGTEE 254 PE L + + ++ D W G L M + +EP+ G + L +I ++ E+ Sbjct: 186 APESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWI-GLNGSQILHKIDKEGERLPRPED 243 Query: 255 LYGYLKKYHIDLDPHFNDILGQH 277 + + H + Sbjct: 244 CPQDIYNVMVQCWAHKPEDRPTF 266 >4LRM-A nrPDB Length = 334 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 49/294 (16%), Positives = 118/294 (40%), Gaps = 38/294 (12%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERV----VVKILK----PVKKKKIKREVKILE 87 + +++ ++ LG G + V++ + I E+V +K L+ P K+I E ++ Sbjct: 17 KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMA 76 Query: 88 NLRGG--TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMY----EL 141 ++ ++ +L+ ++ T L+ + + + D Y+ ++ Sbjct: 77 SVDNPGNPHVCRLLGIC---LTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQI 133 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVA--SRYF 198 K ++Y + ++HRD+ NV++ Q +++ D+GLA+ +EY+ + Sbjct: 134 AKGMNYLEDRRLVHRDLAARNVLVKTPQ-HVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 192 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258 E ++ +++Y + D+WS G + ++ + G + +E Sbjct: 193 MALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDG------------IPASEISSIL 239 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQ 312 K + P + K W I +++R ++ K+ D Q+ Sbjct: 240 EKGERLPQPPICTIDVYMIMVKCW--MIDADSRPKFRELIIEF-SKM-ARDPQR 289 >1U54-B nrPDB Length = 291 Score = 162 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 53/263 (20%), Positives = 99/263 (37%), Gaps = 29/263 (11%) Query: 37 QDDYQLVRKLGRGKYSEVFEAI-NITNNERV--VVKILKP------VKKKKIKREVKILE 87 + D +L+ KLG G + V + + + V VK LKP REV + Sbjct: 17 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMH 76 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLK 143 +L N+I+L V P K +V E + + Y ++ + Sbjct: 77 SL-DHRNLIRLYGVVLTPPMK---MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAE 132 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV----RVASRYFK 199 + Y SK +HRD+ N+++ + +++ D+GL ++ V R + Sbjct: 133 GMGYLESKRFIHRDLAARNLLLATRD-LVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWC 191 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMI-FRREPFFHGQDNYDQLVRI----AKVLGTEE 254 PE L + + ++ D W G L M + +EP+ G + L +I ++ E+ Sbjct: 192 APESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWI-GLNGSQILHKIDKEGERLPRPED 249 Query: 255 LYGYLKKYHIDLDPHFNDILGQH 277 + + H + Sbjct: 250 CPQDIYNVMVQCWAHKPEDRPTF 272 >5IKW-A nrPDB Length = 310 Score = 161 bits (407), Expect = 5e-40, Method: Composition-based stats. Identities = 50/221 (22%), Positives = 92/221 (41%), Gaps = 26/221 (11%) Query: 41 QLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKI---KREVKILENLRGGTNIIK 97 L L G +S VF R +K + + KRE+ I++ L G NI+ Sbjct: 17 TLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVG 75 Query: 98 LIDTVKDPVSKTPA---LVFEYINNTDF-----KQLYQILTDFDIRFYMYELLKALDYCH 149 +D + +S ++ EY K+L T+ ++ + +A+ H Sbjct: 76 YLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLH 135 Query: 150 SKG--IMHRDVKPHNVMIDHQQKKLRLIDWGLA--EFYHPAQEYNVRV-------ASRYF 198 I+HRD+K N++++ + L D+G A +F +P ++ V + + Sbjct: 136 QCKTPIIHRDLKVENILLNDGGNYV-LCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSY 194 Query: 199 KGPELLV--DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQ 237 + PE++ + D+W+LGC+L + F PF Q Sbjct: 195 RAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQ 235 >5UIU-A nrPDB Length = 323 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 42/203 (20%), Positives = 83/203 (40%), Gaps = 24/203 (11%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKIL-------KPVKKKKIKREVKILENLRGGTNIIK 97 K+G G + V++ NN V VK L K++ +E+K++ + N+++ Sbjct: 54 KMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQH-ENLVE 110 Query: 98 LIDTVKDPVSKTPALVFEYINNTDFKQLYQILT-----DFDIRFYMYE-LLKALDYCHSK 151 L+ D LV+ Y+ N L + +R + + +++ H Sbjct: 111 LLGFSSD--GDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN 168 Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAE---FYHPAQEYNVRVASRYFKGPELLVDYQ 208 +HRD+K N+++D + ++ D+GLA + + V + + PE L Sbjct: 169 HHIHRDIKSANILLD-EAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE- 226 Query: 209 MYDYSLDMWSLGCMLASMIFRRE 231 D++S G +L +I Sbjct: 227 -ITPKSDIYSFGVVLLEIITGLP 248 >4M66-A nrPDB Length = 325 Score = 158 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 57/229 (24%), Positives = 102/229 (44%), Gaps = 21/229 (9%) Query: 19 LRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK 78 + S + W A ++++ + + +G+G + VF A + T N V VKI+ KK Sbjct: 1 MSSVKLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNS---KK 57 Query: 79 IKREVKILENLRGGTNIIKLIDTVKDPVSKTP---ALVFEYINNTDFKQLYQILTDFD-- 133 I EVK + NLR N++ L+ +D ALV ++ N L Q Sbjct: 58 ISWEVKAMVNLRN-ENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWP 116 Query: 134 -IRFYMYELLKALDYCHSKG--IMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-------Y 183 + + E++ + Y HS ++HRD+KP N+++D + +L D+GL+ F Sbjct: 117 LLCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPEL-HAKLADFGLSTFQGGSQSGS 175 Query: 184 HPAQEYNVRVASRYFKGPELLVDYQ-MYDYSLDMWSLGCMLASMIFRRE 231 + + PELL + D++S G ++ +++ RE Sbjct: 176 GSGSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGRE 224 >5U6B-A nrPDB Length = 307 Score = 158 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 49/307 (15%), Positives = 107/307 (34%), Gaps = 70/307 (22%) Query: 42 LVRKLGRGKYSEVFEAINITNN--ERVVVKILK-----PVKKKKIKREVKILENLRGGTN 94 L + LG G++ V E ++ +V VK +K + + E ++ N Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEF-DHPN 85 Query: 95 IIKLIDTV----KDPVSKTPALVFEYINNTDFKQLYQI---------LTDFDIRFYMYEL 141 +++LI + P ++ ++ + D L + +M ++ Sbjct: 86 VMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADI 145 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY---F 198 ++Y +K +HRD+ N M++ + + + D+GL++ + Y ++ + Sbjct: 146 ASGMEYLSTKRFIHRDLAARNCMLN-ENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKW 204 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258 E L D ++Y D+WS G + + R + + G +N + Sbjct: 205 IAIESLAD-RVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIY--------------- 248 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD----LLDKLLRYDHQQRL 314 +++ NR + LD L+ + + Q R Sbjct: 249 -------------------------DYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRP 283 Query: 315 TAKEAME 321 + E E Sbjct: 284 SFTELRE 290 >3MDY-A nrPDB Length = 337 Score = 157 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 67/304 (22%), Positives = 113/304 (37%), Gaps = 52/304 (17%) Query: 41 QLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILEN-LRGGTNIIKLI 99 Q+V+++G+G+Y EV+ E+V VK+ ++ RE +I + L NI+ I Sbjct: 40 QMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFI 97 Query: 100 --DTVKDPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDYCHSK---- 151 D L+ +Y N + L + Y + L + H++ Sbjct: 98 AADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFST 157 Query: 152 ----GIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEY----NVRVASRYFKGPE 202 I HRD+K N+++ + + D GLA +F E N RV ++ + PE Sbjct: 158 QGKPAIAHRDLKSKNILV-KKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE 216 Query: 203 LLVD------YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY 256 +L + +Q Y DM+S G +L + R G E Y Sbjct: 217 VLDESLNRNHFQSY-IMADMYSFGLILWEVARRCV-----------------SGGIVEEY 258 Query: 257 GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEAL----DLLDKLLRYDHQQ 312 + DP + D+ + S S E L L+ + ++ Sbjct: 259 QLPYHDLVPSDPSYEDMREIV---CIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS 315 Query: 313 RLTA 316 RLTA Sbjct: 316 RLTA 319 >1PY5-A nrPDB Length = 326 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 49/274 (17%), Positives = 104/274 (37%), Gaps = 38/274 (13%) Query: 42 LVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLR-GGTNIIKLI- 99 L +G+G++ EV+ E V VKI +++ RE +I + + NI+ I Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA 90 Query: 100 -DTVKDPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDYCH------- 149 D + LV +Y + +T + L + H Sbjct: 91 ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ 150 Query: 150 -SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY-----NVRVASRYFKGPEL 203 I HRD+K N+++ + + D GLA + A + N RV ++ + PE+ Sbjct: 151 GKPAIAHRDLKSKNILV-KKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEV 209 Query: 204 L---VDYQMYD--YSLDMWSLGCMLASMIFRRE----------PFFHGQDNYDQLVRIAK 248 L ++ + ++ D++++G + + R P++ + + + K Sbjct: 210 LDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRK 269 Query: 249 VLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRW 282 V+ ++L + + ++ + R+ W Sbjct: 270 VVCEQKLRPNIPNRWQSCEALR--VMAKIMRECW 301 >5L2Q-C nrPDB Length = 320 Score = 155 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 52/311 (16%), Positives = 106/311 (34%), Gaps = 80/311 (25%) Query: 55 FEAINITNNERVVVKILKPVKKKK--------------IKREVKILENLRGGTNIIKLID 100 A ++ +KIL ++ + E +L L ++ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 101 TVKDPV----------------SKTPALVFEYINNTDFKQL-------------YQILTD 131 +D K LV + + DF + L++ Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 132 FDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYN 190 + Y++++ ++ H K I+HRD+K N++++ + ++ + ++ L + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 191 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVL 250 + S + P++L DMW+LG +L +M++ + PF+ Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSI------------- 259 Query: 251 GTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDH 310 +EL+ +K + VS + L+ KLL D Sbjct: 260 -PQELFRKIKAAEYTIPED----------------------GRVSENTVCLIRKLLVLDP 296 Query: 311 QQRLTAKEAME 321 QQRL A + +E Sbjct: 297 QQRLAAADVLE 307 >5TOS-A nrPDB Length = 395 Score = 154 bits (389), Expect = 5e-38, Method: Composition-based stats. Identities = 52/327 (15%), Positives = 109/327 (33%), Gaps = 51/327 (15%) Query: 39 DYQLVRKLGRGKYSEVFEA---------INITNNERVVVKILKP---VKKKKIKREVKIL 86 +++ +G G + VF+ + VK L ++ E+ L Sbjct: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-------QILTDFDIRFYMY 139 L N++KLI + + LV+E++ + + L F Sbjct: 126 GQL-SHPNLVKLIGYCLEDEHR--LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 Query: 140 ELLKALDYCHS--KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF--YHPAQEYNVRV-A 194 + K L + HS +++RD+K N+++D +L D+GLA + RV Sbjct: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLARDGPMGDLSYVSTRVMG 241 Query: 195 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE 254 + + PE + + + D++S G +L ++ + H + Sbjct: 242 TYGYAAPEYMSSGHL-NARSDVYSFGVLLLEILSGKRALDHNR---------------PA 285 Query: 255 LYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL 314 L + +L + ++ E + S + L ++ + R Sbjct: 286 KEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV-----QCLSFEPKSRP 340 Query: 315 TAKEAMEHPYFYPVVKEQSQPCADNAV 341 T + + + +P N V Sbjct: 341 TMDQVVRA--LQQLQDNLGKPSQTNPV 365 >4NEU-A nrPDB Length = 333 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 54/308 (17%), Positives = 114/308 (37%), Gaps = 39/308 (12%) Query: 26 DYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP-----VKKKKIK 80 D +V + D + +L G + +V + T +++K + + + Sbjct: 13 DMSLNVIKMKSSDFLE-SAELDSGGFGKVSLCFHRTQG-LMIMKTVYKGPNCIEHNEALL 70 Query: 81 REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL--TDFDIR-FY 137 E K++ LR ++KL+ + + +LV EY+ + + + T ++ Sbjct: 71 EEAKMMNRLRHSR-VVKLLGVIIE--EGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRI 127 Query: 138 MYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA--------------EFY 183 + E+++ + Y H KG++H+D+KP N+++D+ +++ D GLA E Sbjct: 128 ILEIIEGMCYLHGKGVIHKDLKPENILVDN-DFHIKIADLGLASFKMWSKLNNEEHNELR 186 Query: 184 HPAQEYNVRVASRYFKGPELLVDYQ-MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQ 242 + Y+ PE L D D++S +L ++ +EP+ + Sbjct: 187 EVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQL 246 Query: 243 LVRIAKVLGT---------EELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHL 293 ++ I L K + +P K + F S+ Sbjct: 247 IMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEK-FRPFYLSQLEES 305 Query: 294 VSPEALDL 301 V + L Sbjct: 306 VEEDVKSL 313 >5WNL-A nrPDB Length = 342 Score = 153 bits (388), Expect = 7e-38, Method: Composition-based stats. Identities = 48/290 (16%), Positives = 121/290 (41%), Gaps = 50/290 (17%) Query: 44 RKLGRGKYSEVFEAINITNNERVVVKI-----LKPVKKKKIKREVKILENLRGGTNIIKL 98 K+G G + +V++ ++ + +K + ++ ++ E K +E + I+ + Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAK-FRYILPV 84 Query: 99 IDTVKDPVSKTPALVFEYINNTDFKQLYQILT-DFDIRF-YMYELLKALDYCH--SKGIM 154 ++PV LV EY+ ++L +D+RF ++E +++ H S ++ Sbjct: 85 YGICQEPVG----LVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLL 140 Query: 155 HRDVKPHNVMIDHQQKKLRLIDWGLAEF----YHPAQEYNVRVASRYFKGPELLVDY-QM 209 H ++KP N+++D +++ D+GLA+ + + + + PE + + ++ Sbjct: 141 HLNLKPANILLDA-HYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRL 199 Query: 210 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 269 +D D++S ++ ++ +++PF ++ ++++ +K + +L P Sbjct: 200 FDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKV------------VKGHRPELPPI 247 Query: 270 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 R + L+ + D Q R T +E Sbjct: 248 CRP------------------RPRACASLIGLMQRCWHADPQVRPTFQEI 279 >6DC0-A nrPDB Length = 292 Score = 150 bits (380), Expect = 6e-37, Method: Composition-based stats. Identities = 57/299 (19%), Positives = 112/299 (37%), Gaps = 44/299 (14%) Query: 54 VFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALV 113 V A+ I + K+ P+K + K ++ L +NI +++ + Sbjct: 22 VSRALCIHTGRELRCKVF-PIKHYQDK--IRPYIQLPSHSNITGIVEVILGETKAYVFFE 78 Query: 114 FEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQK-KL 172 ++ + + + + L + + +++ A+ +CH I+ D+K + +++ +L Sbjct: 79 KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQL 138 Query: 173 RLIDWGLAEFYH-PAQEYNVRVASRYFKGPELLVDYQMY-DYSLDMWSLGCMLASMIFRR 230 RL + + + PE+L Y + D+WSLG ML +++ R Sbjct: 139 RLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGR 198 Query: 231 EPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSEN 290 PF H +D S+ R F E+ Sbjct: 199 YPF-----------------------------------HDSDPSALFSKIRRGQFCIPEH 223 Query: 291 RHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAA 349 +SP+A L+ LLR + +RLTA E + HP+F V++ + T+ Sbjct: 224 ---ISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEGSGSSGGPGGGICEHETSI 279 >5U6C-A nrPDB Length = 315 Score = 150 bits (379), Expect = 8e-37, Method: Composition-based stats. Identities = 42/257 (16%), Positives = 101/257 (39%), Gaps = 29/257 (11%) Query: 36 NQDDYQLVRKLGRGKYSEVFEA---INITNNERVVVKILK-----PVKKKKIKREVKILE 87 +++ L + LG G++ V E + +V VK +K + ++ E ++ Sbjct: 34 DRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMK 93 Query: 88 NLRGGTNIIKLIDTVKDPVSK---TPALVFEYINNTDFKQLY---------QILTDFDIR 135 + N+++L+ + S+ P ++ ++ D + + + Sbjct: 94 DF-SHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLL 152 Query: 136 FYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVAS 195 +M ++ ++Y ++ +HRD+ N M+ + + D+GL++ + Y + Sbjct: 153 KFMVDIALGMEYLSNRNFLHRDLAARNCML-RDDMTVCVADFGLSKKIYSGDYYRQGRIA 211 Query: 196 RY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDN---YDQLVRIAKV 249 + + E L D ++Y D+W+ G + + R + G N YD L+ ++ Sbjct: 212 KMPVKWIAIESLAD-RVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRL 270 Query: 250 LGTEELYGYLKKYHIDL 266 E+ L + Sbjct: 271 KQPEDCLDELYEIMYSC 287 >3G2F-A nrPDB Length = 336 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 57/310 (18%), Positives = 113/310 (36%), Gaps = 45/310 (14%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILEN-LRGGTNII 96 D+ +L+ +GRG+Y V++ + V VK+ ++ E I L NI Sbjct: 13 DNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIA 70 Query: 97 KLI---DTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFY--MYELLKALDYCHSK 151 + I + V LV EY N + + T + + + + L Y H++ Sbjct: 71 RFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTE 130 Query: 152 ---------GIMHRDVKPHNVMIDHQQKKLRLIDWGLA------EFYHPAQEYN---VRV 193 I HRD+ NV++ + + D+GL+ P +E N V Sbjct: 131 LPRGDHYKPAISHRDLNSRNVLVKN-DGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEV 189 Query: 194 ASRYFKGPELLVD------YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIA 247 + + PE+L + +DM++LG + + R F G+ + + Sbjct: 190 GTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQ 249 Query: 248 KVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLR 307 +G + ++ + + R ++ + + S + ++ Sbjct: 250 TEVGNHPTFEDMQVL----------VSREKQRPKFPEAWKENSLAVRS--LKETIEDCWD 297 Query: 308 YDHQQRLTAK 317 D + RLTA+ Sbjct: 298 QDAEARLTAQ 307 >4F0G-A nrPDB Length = 287 Score = 149 bits (377), Expect = 1e-36, Method: Composition-based stats. Identities = 40/217 (18%), Positives = 92/217 (42%), Gaps = 28/217 (12%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL----------KPVKKKKIKREVKILE 87 ++ + +++G+G + V + + + V +K L K ++ +REV I+ Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMS 78 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY----QILTDFDIRFYMYELLK 143 NL NI+KL + +P P +V E++ D + M ++ Sbjct: 79 NL-NHPNIVKLYGLMHNP----PRMVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIAL 133 Query: 144 ALDYCHSKG--IMHRDVKPHNVMIDHQQKK----LRLIDWGLAEFYHPAQEYNVRVASRY 197 ++Y ++ I+HRD++ N+ + + ++ D+GL++ + + + Sbjct: 134 GIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ--QSVHSVSGLLGNFQ 191 Query: 198 FKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRREPF 233 + PE + + + Y D +S +L +++ PF Sbjct: 192 WMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPF 228 >3AOX-A nrPDB Length = 344 Score = 149 bits (377), Expect = 1e-36, Method: Composition-based stats. Identities = 48/300 (16%), Positives = 99/300 (33%), Gaps = 44/300 (14%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAI-----NITNNERVVVKILKPVKKKK----IKREVKIL 86 + + L+R LG G + EV+E N + +V VK L V ++ E I+ Sbjct: 45 PRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALII 104 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----------ILTDFDIRF 136 NI++ I S ++ E + D K + L D+ Sbjct: 105 SKFNHQ-NIVRCIGV--SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLH 161 Query: 137 YMYELLKALDYCHSKGIMHRDVKPHNVMID--HQQKKLRLIDWGLAEFYHPAQEYNVRVA 194 ++ Y +HRD+ N ++ + ++ D+G+A + A Y Sbjct: 162 VARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGC 221 Query: 195 ---SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG 251 + PE ++ ++ D WS G +L + + + N + L + Sbjct: 222 AMLPVKWMPPEAFME-GIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTS--- 277 Query: 252 TEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQ 311 +D + + + + W++ + E ++ + D Sbjct: 278 ---------GGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQ----DPD 324 >3QD2-B nrPDB Length = 332 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 48/268 (17%), Positives = 98/268 (36%), Gaps = 81/268 (30%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKIL----KPVKKKKIKREVKILENLRGGTN 94 D++ ++ +GRG + VFEA N ++ +K + + + ++K+ REVK L L Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEH-PG 65 Query: 95 IIKLIDTVKD-------------------------------------------------- 104 I++ + + Sbjct: 66 IVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVG 125 Query: 105 ---PVSKTPAL--VFEYINNTDFKQLYQILTDFDIR------FYMYELLKALDYCHSKGI 153 P S L + + K + R ++ +A+++ HSKG+ Sbjct: 126 QLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGL 185 Query: 154 MHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-------------YNVRVASRYFKG 200 MHRD+KP N+ +++ D+GL +E + +V ++ + Sbjct: 186 MHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMS 244 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIF 228 PE + Y + +D++SLG +L +++ Sbjct: 245 PEQIHGNN-YSHKVDIFSLGLILFELLY 271 >5LPZ-A nrPDB Length = 332 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 41/209 (19%), Positives = 88/209 (42%), Gaps = 22/209 (10%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK---KKKIKREVKILENLRGGTNII 96 + +G G + +V++AI + + V +K L V ++ E++ + ++ N++ Sbjct: 19 FHNDSLIGSGGFGDVYKAI-LKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKH-RNLV 76 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-------ILTDFDIRFYMYELLKALDYCH 149 L+ K V LV+E++ + + L R + L + H Sbjct: 77 PLLGYCK--VGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134 Query: 150 ---SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY---NVRVASRYFKGPEL 203 S I+HRD+K NV++D + + R+ D+G+A + + + + PE Sbjct: 135 HNCSPHIIHRDMKSSNVLLD-ENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY 193 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREP 232 ++ D++S G +L ++ + P Sbjct: 194 YQSFR-CSTKGDVYSYGVVLLELLTGKRP 221 >5CEK-A nrPDB Length = 263 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 56/280 (20%), Positives = 109/280 (38%), Gaps = 44/280 (15%) Query: 54 VFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALV 113 V A+ I + K+ P+K + K ++ L +NI +++ + Sbjct: 25 VSRALCIHTGRELRCKVF-PIKHYQDK--IRPYIQLPSHSNITGIVEVILGETKAYVFFE 81 Query: 114 FEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQK-KL 172 ++ + + + + L + + +++ A+ +CH I+ D+K + +++ +L Sbjct: 82 KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQL 141 Query: 173 RLIDWGLAEFYH-PAQEYNVRVASRYFKGPELLVDYQMY-DYSLDMWSLGCMLASMIFRR 230 RL + + + PE+L Y + D+WSLG ML +++ R Sbjct: 142 RLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGR 201 Query: 231 EPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSEN 290 PF H +D S+ R F E+ Sbjct: 202 YPF-----------------------------------HDSDPSALFSKIRRGQFCIPEH 226 Query: 291 RHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVK 330 +SP+A L+ LLR + +RLTA E + HP+F V++ Sbjct: 227 ---ISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLE 263 >3SOC-A nrPDB Length = 322 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 57/300 (19%), Positives = 114/300 (38%), Gaps = 42/300 (14%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRG--GTNIIK 97 QL+ RG++ V++A + NE V VKI K+ + E ++ +L G NI++ Sbjct: 26 LQLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNEYEVY-SLPGMKHENILQ 82 Query: 98 LIDTVKDPVSKT--PALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDYCHS--- 150 I K S L+ + + +++ ++ + + L Y H Sbjct: 83 FIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIP 142 Query: 151 -------KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ---EYNVRVASRYFKG 200 I HRD+K NV++ + + D+GLA + + + + +V +R + Sbjct: 143 GLKDGHKPAISHRDIKSKNVLLKNNLTAC-IADFGLALKFEAGKSAGDTHGQVGTRRYMA 201 Query: 201 PELLVDYQMYDY----SLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY 256 PE+L + +DM+++G +L + R D Y ++ + +G Sbjct: 202 PEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEY--MLPFEEEIGQHPSL 259 Query: 257 GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA 316 +++ + + R W+ E D +D + RL+A Sbjct: 260 EDMQEVVV------HKKKRPVLRDYWQKHAGMAMLCETIEECWD-------HDAEARLSA 306 >5LPV-A nrPDB Length = 296 Score = 147 bits (372), Expect = 5e-36, Method: Composition-based stats. Identities = 41/209 (19%), Positives = 88/209 (42%), Gaps = 22/209 (10%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK---KKKIKREVKILENLRGGTNII 96 + +G G + +V++AI + + V +K L V ++ E++ + ++ N++ Sbjct: 19 FHNDSLIGSGGFGDVYKAI-LKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKH-RNLV 76 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-------ILTDFDIRFYMYELLKALDYCH 149 L+ K V LV+E++ + + L R + L + H Sbjct: 77 PLLGYCK--VGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134 Query: 150 ---SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEY---NVRVASRYFKGPEL 203 S I+HRD+K NV++D + + R+ D+G+A + + + + PE Sbjct: 135 HNCSPHIIHRDMKSSNVLLD-ENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY 193 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREP 232 ++ D++S G +L ++ + P Sbjct: 194 YQSFR-CSTKGDVYSYGVVLLELLTGKRP 221 >3UIM-A nrPDB Length = 326 Score = 147 bits (372), Expect = 5e-36, Method: Composition-based stats. Identities = 54/283 (19%), Positives = 103/283 (36%), Gaps = 25/283 (8%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGGT 93 D++ LGRG + +V++ + + V VK LK + + + + EV+++ Sbjct: 30 DNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVH-R 87 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI-------RFYMYELLKALD 146 N+++L P + LV+ Y+ N + + + + L Sbjct: 88 NLLRLRGFCMTPTER--LLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLA 145 Query: 147 YCHSK---GIMHRDVKPHNVMIDHQQKKLRLIDWGLAE--FYHPAQEYNVRVASRYFKGP 201 Y H I+HRDVK N+++D + + + + D+GLA+ Y + P Sbjct: 146 YLHDHCDPKIIHRDVKAANILLDEEFEAV-VGDFGLAKLMDYKDTHVTTAVRGTIGHIAP 204 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPF---FHGQDNYDQLVRIAKVLGTEELYGY 258 E L + D++ G ML +I + F D+ L+ K L E+ Sbjct: 205 EYLSTGKS-SEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKLEA 263 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDL 301 L + + ++ R +S L Sbjct: 264 LVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVVRML 306 >6J5U-C nrPDB Length = 426 Score = 147 bits (371), Expect = 8e-36, Method: Composition-based stats. Identities = 64/334 (19%), Positives = 113/334 (33%), Gaps = 54/334 (16%) Query: 39 DYQLVRKLGRGKYSEVFEAINITN---------NERVVVKILKP---VKKKKIKREVKIL 86 +++ LG G + VF+ V VK LKP K+ EV L Sbjct: 85 NFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEWLTEVNYL 144 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-----QILTDFDIRFYMYEL 141 L N++ L+ + ++ LV+E++ + Q LT Sbjct: 145 GQL-SHPNLVLLVGYCAEGENR--LLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGA 201 Query: 142 LKALDYCHSKG--IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR---VASR 196 K L + H +++RD K N+++D +L D+GLA+ +V + + Sbjct: 202 AKGLTFLHEAKSQVIYRDFKAANILLDA-DFNAKLSDFGLAKAGPTGDNTHVSTKVIGTH 260 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY 256 + PE + ++ D++S G +L +I R DN + + V Sbjct: 261 GYAAPEYVATGRL-TAKSDVYSFGVVLLELISGR----RAMDNSNGGNEYSLVDWATPYL 315 Query: 257 GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA 316 G +K +D Q A +L + L D + R Sbjct: 316 GDKRKLFRIMDTKLGGQYPQKGAFT----------------AANLALQCLNPDAKLRPKM 359 Query: 317 KEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR 350 E + V EQ + A + + + R Sbjct: 360 SEVL-------VTLEQLESVAKPGTKHTQMESPR 386 >2H34-A nrPDB Length = 309 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 48/209 (22%), Positives = 92/209 (44%), Gaps = 16/209 (7%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVKILENLRGGT 93 Y+L R +GRG +V+EA + V +K++ PV + +++RE + L+ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQ-EP 94 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHS 150 +++ + D + + + IN D + + L + ++ ALD H+ Sbjct: 95 HVVPIHDFGE--IDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHA 152 Query: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ--EYNVRVASRYFKGPELLVDYQ 208 G HRDVKP N+++ L+D+G+A + + V + Y+ PE + Sbjct: 153 AGATHRDVKPENILVSADDFAY-LVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESH 211 Query: 209 MYDYSLDMWSLGCMLASMIFRREPFFHGQ 237 Y D+++L C+L + P+ Q Sbjct: 212 A-TYRADIYALTCVLYECLTGSPPYQGDQ 239 >5E8V-A nrPDB Length = 316 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 58/305 (19%), Positives = 118/305 (38%), Gaps = 45/305 (14%) Query: 41 QLVRKLGRGKYSEVFEAINITNN----ERVVVKILKPVKKKKIKREVKILENLR-GGTNI 95 +L +G+G+++EV++A N E V VKI + K E I ++ NI Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENI 71 Query: 96 IKLIDTVKDPV--SKTPALVFEYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCHS- 150 ++ + + K L+ + + ++ +++ D+R L + + + HS Sbjct: 72 LQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSD 131 Query: 151 --------KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV-----RVASRY 197 I+HRD+K N+++ + L D+GL+ P + +V + Sbjct: 132 HTPCGRPKMPIVHRDLKSSNILVKNDLTCC-LCDFGLSLRLDPTLSVDDLANSGQVGTAR 190 Query: 198 FKGPELLVDYQMYD-----YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT 252 + PE+L + D++S+ +L M R + +V Sbjct: 191 YMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRC-------------NAVGEVKDY 237 Query: 253 EELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQ 312 E +G + H + +++L R +F + + E L + +D + Sbjct: 238 EPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCET---LTECWDHDPEA 294 Query: 313 RLTAK 317 RLTA+ Sbjct: 295 RLTAQ 299 >3ZZW-A nrPDB Length = 289 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 43/272 (15%), Positives = 103/272 (37%), Gaps = 39/272 (14%) Query: 41 QLVRKLGRGKYSEVFEAINI-----TNNERVVVKILKPVK----KKKIKREVKILENLRG 91 + + +LG ++ +V++ + V +K LK +++ + E + L+ Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQH 71 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-------------------QILTDF 132 N++ L+ V + +++F Y ++ D + L Sbjct: 72 -PNVVCLLGVV--TKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPP 128 Query: 133 DIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR 192 D + ++ ++Y S ++H+D+ NV++ + + +++ D GL + A Y + Sbjct: 129 DFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLV-YDKLNVKISDLGLFREVYAADYYKLL 187 Query: 193 VASR---YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK- 248 S + PE ++ Y + D+WS G +L + + G N D + I Sbjct: 188 GNSLLPIRWMAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNR 246 Query: 249 --VLGTEELYGYLKKYHIDLDPHFNDILGQHS 278 + ++ ++ I+ F + Sbjct: 247 QVLPCPDDCPAWVYALMIECWNEFPSRRPRFK 278 >5WNO-A nrPDB Length = 330 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 46/280 (16%), Positives = 107/280 (38%), Gaps = 36/280 (12%) Query: 41 QLVRKLGRGKYSEVFEAIN-----ITNNERVVVKILKPVKKK--KIKREVKILENLRGGT 93 +L +KLG G + VF I V +K+ + + + ++ E + LR Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRH-D 83 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTD----FDIRFYMYELLKALDYCH 149 N++K+I +V Y + + ++ + + Y Y++ + Y Sbjct: 84 NLLKIIGFCMH--DDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLE 141 Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFY-HPAQEYNVRVASRY--FKGPELLVD 206 + ++HRD+ NV++ + + + D+GL++ H A ++ + E+ Sbjct: 142 KQRVVHRDLATRNVLV-KKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSK 200 Query: 207 YQMYDYSLDMWSLGCMLASMIF-RREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY-HI 264 + Y ++ D+W+ G +I + P+ + + T+ ++ +LK + Sbjct: 201 HC-YTHASDVWAFGVTCWEIITFGQSPY--------------QGMSTDSIHNFLKDGNRL 245 Query: 265 DLDPHFNDILGQHSRKRWENFIHS-ENRHLVSPEALDLLD 303 P+ + L Q + W S ++ + Sbjct: 246 SQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCK 285 >4FL3-A nrPDB Length = 635 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 40/237 (16%), Positives = 96/237 (40%), Gaps = 29/237 (12%) Query: 12 VYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAI-----NITNNERV 66 +A+ +R +E + +D ++LG G + V + + Sbjct: 351 PFADPEEIRPKEVY----LDRKLLTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVK 402 Query: 67 VVK--ILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQ 124 ++K P K ++ E +++ L I+++I + +++ LV E + Sbjct: 403 ILKNEANDPALKDELLAEANVMQQLDN-PYIVRMIGICE---AESWMLVMEMAELGPLNK 458 Query: 125 LYQI---LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE 181 Q + D +I ++++ + Y +HRD+ NV++ Q ++ D+GL++ Sbjct: 459 YLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLL-VTQHYAKISDFGLSK 517 Query: 182 FYH-PAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRREPF 233 Y + ++ + PE + Y+ + D+WS G ++ + ++P+ Sbjct: 518 ALRADENYYKAQTHGKWPVKWYAPECINYYK-FSSKSDVWSFGVLMWEAFSYGQKPY 573 >5C26-A nrPDB Length = 299 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 41/237 (17%), Positives = 96/237 (40%), Gaps = 29/237 (12%) Query: 12 VYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAI-----NITNNERV 66 YA+ +R +E + +D ++LG G + V + + Sbjct: 9 PYADPEEIRPKEVY----LDRKLLTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVK 60 Query: 67 VVK--ILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQ 124 ++K P K ++ E +++ L I+++I + +++ LV E + Sbjct: 61 ILKNEANDPALKDELLAEANVMQQLDN-PYIVRMIGICE---AESWMLVMEMAELGPLNK 116 Query: 125 LYQI---LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE 181 Q + D +I ++++ + Y +HRD+ NV++ Q ++ D+GL++ Sbjct: 117 YLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLL-VTQHYAKISDFGLSK 175 Query: 182 FYH-PAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLAS-MIFRREPF 233 Y + ++ + PE + Y+ + D+WS G ++ + ++P+ Sbjct: 176 ALRADENYYKAQTHGKWPVKWYAPECINYYK-FSSKSDVWSFGVLMWEAFSYGQKPY 231 >5XD6-A nrPDB Length = 305 Score = 140 bits (353), Expect = 9e-34, Method: Composition-based stats. Identities = 42/215 (19%), Positives = 84/215 (39%), Gaps = 26/215 (12%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKK--KKIKREVKILENLRGGTNI 95 D+Y +G G Y VF I + + + +K L K+ ++ +V ++ LR N+ Sbjct: 22 DNYGSKSLIGEGSYGRVFYGI-LKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQ-ENV 79 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ------------ILTDFDIRFYMYELLK 143 + L+ D + L +EY N + +L+ + Sbjct: 80 VALLGYCVDGPLR--VLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAAR 137 Query: 144 ALDYCHSK---GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ---EYNVRVASRY 197 L+Y H K ++HRD+K NV++ ++ D+ L+ + + Sbjct: 138 GLEYLHEKANPHVIHRDIKSSNVLLFDDD-VAKIADFDLSNQAPDMAARLHSTRVLGTFG 196 Query: 198 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREP 232 + PE + + D++S G +L ++ R+P Sbjct: 197 YHAPEYAMTGTL-STKSDVYSFGVVLLELLTGRKP 230 >2QLU-A nrPDB Length = 314 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 55/299 (18%), Positives = 116/299 (38%), Gaps = 39/299 (13%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENL-RGGTNIIKL 98 QL+ RG++ V++A + N+ V VKI K+ + E +I N+++ Sbjct: 17 LQLLEIKARGRFGCVWKAQLM--NDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQF 74 Query: 99 IDTVK--DPVSKTPALVFEYINNTDFKQLYQ--ILTDFDIRFYMYELLKALDYCHS---- 150 I K + L+ + + + I+T ++ + + L Y H Sbjct: 75 IAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPW 134 Query: 151 -------KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ---EYNVRVASRYFKG 200 I HRD K NV++ + L D+GLA + P + + + +V +R + Sbjct: 135 CRGEGHKPSIAHRDFKSKNVLLKSDLTAV-LADFGLAVRFEPGKPPGDTHGQVGTRRYMA 193 Query: 201 PELLVDYQMYDY----SLDMWSLGCMLASMIFRRE-----------PFFHGQDNYDQLVR 245 PE+L + +DM+++G +L ++ R + PF + L Sbjct: 194 PEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEE 253 Query: 246 IAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDK 304 + +V+ +++ +K + + L + W++ + E + L+ + Sbjct: 254 LQEVVVHKKMRPTIKDHWLKHPGLAQ--LCVTIEECWDHDAEARLSAGCVEERVSLIRR 310 >2QKW-B nrPDB Length = 321 Score = 137 bits (345), Expect = 8e-33, Method: Composition-based stats. Identities = 49/287 (17%), Positives = 109/287 (37%), Gaps = 38/287 (13%) Query: 46 LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLR--GGTNIIKLIDTVK 103 +G G + +V++ + + + +V +K P + I+ +E L +++ LI Sbjct: 47 IGHGVFGKVYKGV-LRDGAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCD 105 Query: 104 DPVSKTPALVFEYINNTDFKQLY-------QILTDFDIRFYMYELLKALDYCHSKGIMHR 156 + L+++Y+ N + K+ ++ + L Y H++ I+HR Sbjct: 106 E--RNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHR 163 Query: 157 DVKPHNVMIDHQQKKLRLIDWGLAE---FYHPAQEYNVRVASRYFKGPELLVDYQMYDYS 213 DVK N+++D + ++ D+G+++ V + + PE + ++ Sbjct: 164 DVKSINILLD-ENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRL-TEK 221 Query: 214 LDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDI 273 D++S G +L ++ R A V L ++ ++ H N Sbjct: 222 SDVYSFGVVLFEVLC---------------ARSAIVQSLPREMVNLAEWAVE--SHNNGQ 264 Query: 274 LGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 320 L Q + I E+ A+ K L + R + + + Sbjct: 265 LEQIVDPNLADKIRPESLRKFGDTAV----KCLALSSEDRPSMGDVL 307 >3SV0-A nrPDB Length = 483 Score = 137 bits (344), Expect = 9e-33, Method: Composition-based stats. Identities = 56/288 (19%), Positives = 111/288 (38%), Gaps = 32/288 (11%) Query: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-PVKKKKIKREVKILENLR 90 P GN ++L RK+G G + E++ NI NE V +K+ K ++ E KI L+ Sbjct: 3 PRVGN--KFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIYRILQ 60 Query: 91 GGTNI--IKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKAL 145 GGT I ++ D LV + + + F + L+ + +++ + Sbjct: 61 GGTGIPNVRWFGVEGD----YNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRV 116 Query: 146 DYCHSKGIMHRDVKPHNVM--IDHQQKKLRLIDWGLAEFYHPAQEY--------NVRVAS 195 ++ HSK +HRD+KP N + + + ++ +ID+GLA+ Y + + Sbjct: 117 EFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGT 176 Query: 196 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPF--FHGQDNYDQLVRIAKVLGTE 253 + + + D+ SLG +L + P+ + +I++ Sbjct: 177 ARYASVNTHLGIEQ-SRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVAT 235 Query: 254 ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDL 301 + + Y + +F+ F + + DL Sbjct: 236 SIEALCRGYPTEFASYFHYCRSL-------RFDDKPDYSYLKRLFRDL 276 >5AR8-A nrPDB Length = 326 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 52/303 (17%), Positives = 114/303 (37%), Gaps = 44/303 (14%) Query: 43 VRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVKILENLRGGTNII 96 +R L RG V A + +V VK L ++K + RE +IL R + I+ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKAR-FSYIL 95 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTD-----FDIRF-YMYELLKALDYCHS 150 ++ +P + +V EY+ N +L T+ + +RF ++E+ ++Y H+ Sbjct: 96 PILGICNEP--EFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHN 153 Query: 151 K--GIMHRDVKPHNVMIDHQQKKLRLIDWGLAE------FYHPAQEYNVRVASRYFKGPE 202 ++H D+K N+++D++ +++ D+GL++ + + + + PE Sbjct: 154 MTPPLLHHDLKTQNILLDNE-FHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPE 212 Query: 203 LLV--DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK 260 D++S + ++ R++PF + + + ++ + Sbjct: 213 NYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSV-----SQGHRPVIN 267 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR----LTA 316 + + D + W L L+ + R +T Sbjct: 268 EESLPYDIPHRARMISLIESGWAQNPDERP---------SFLKCLIELEPVLRTFEEITF 318 Query: 317 KEA 319 EA Sbjct: 319 LEA 321 >3LMG-A nrPDB Length = 344 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 43/275 (15%), Positives = 111/275 (40%), Gaps = 29/275 (10%) Query: 33 SWGNQDDYQLVRKLGRGKYSEVFEAINITNNE----RVVVKILKPVKKKKIKREVKILEN 88 + + + ++ LG G + V + + I E V +K+++ ++ + V Sbjct: 26 RIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHML 85 Query: 89 L---RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYEL 141 +I++L+ + LV +Y+ + L + + ++ Sbjct: 86 AIGSLDHAHIVRLLGLC---PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQI 142 Query: 142 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE---YNVRVASRYF 198 K + Y G++HR++ NV++ ++++ D+G+A+ P + Y+ + Sbjct: 143 AKGMYYLEEHGMVHRNLAARNVLLKSPS-QVQVADFGVADLLPPDDKQLLYSEAKTPIKW 201 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIF-RREPF--FHGQDNYDQLVRIAKV----LG 251 E + + Y + D+WS G + ++ EP+ + D L + ++ + Sbjct: 202 MALESI-HFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQIC 260 Query: 252 TEELYGYLKKYHI---DLDPHFNDILGQHSRKRWE 283 T ++Y + K + ++ P F ++ + +R + Sbjct: 261 TIDVYMVMVKCWMIDENIRPTFKELANEFTRMARD 295 >2Y4I-B nrPDB Length = 319 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 55/331 (16%), Positives = 113/331 (34%), Gaps = 58/331 (17%) Query: 16 VNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL---- 71 + E +P + ++ +G+G++ +V+ + V ++++ Sbjct: 15 PRKASQTSIFLQEWDIP----FEQLEIGELIGKGRFGQVYHGRW---HGEVAIRLIDIER 67 Query: 72 -KPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ--- 127 + K KREV R N++ + P A++ + + Sbjct: 68 DNEDQLKAFKREVMAYRQTRH-ENVVLFMGACMSP--PHLAIITSLCKGRTLYSVVRDAK 124 Query: 128 -ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL---AEFY 183 +L R E++K + Y H+KGI+H+D+K NV D K+ + D+GL + Sbjct: 125 IVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD--NGKVVITDFGLFSISGVL 182 Query: 184 HPAQEYNVRVASRYF---KGPELLVDYQ--------MYDYSLDMWSLGCMLASMIFRREP 232 + + + PE++ + D+++LG + + R P Sbjct: 183 QAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWP 242 Query: 233 FFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRH 292 F + ++ L I F Q R + + Sbjct: 243 F--KTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLM------ 294 Query: 293 LVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323 D+L+KL + + +RL+ HP Sbjct: 295 -------DMLEKLPKRN--RRLS------HP 310 >2CHL-A nrPDB Length = 351 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 57/283 (20%), Positives = 119/283 (42%), Gaps = 27/283 (9%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRGGTNII 96 ++++ +K+G G + E+ N+ NE V +K L+P+K + ++ E + + L G I Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQLGSGDGIP 89 Query: 97 KLIDTVKDPVSKTPALVFEYINNTD---FKQLYQILTDFDIRFYMYELLKALDYCHSKGI 153 ++ P K A+V E + + F + + + +L+ ++Y HSK + Sbjct: 90 QVY--YFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNL 147 Query: 154 MHRDVKPHNVMI----DHQQKKLRLIDWGLAEFY--------HPAQEYNVRVASRYFKGP 201 ++RDVKP N +I + Q+ + +ID+ LA+ Y P +E+ + + Sbjct: 148 IYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSI 207 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 + + D+ +LG M + P+ + D L + +G + ++ Sbjct: 208 NTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK--ADTLKERYQKIGDTKRATPIEV 264 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDK 304 L +F ++ R +F + + DL D+ Sbjct: 265 ----LCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 303 >5VC6-A nrPDB Length = 289 Score = 133 bits (336), Expect = 7e-32, Method: Composition-based stats. Identities = 49/314 (15%), Positives = 102/314 (32%), Gaps = 75/314 (23%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP-----VKKKKIKREVKILENLRGGT 93 ++ + K+G G++ VF+ + + +K K V ++ REV L + Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQ-------LYQILTDFDIRFYMYELLKALD 146 ++++ + + EY N + + +++ + ++ + L Sbjct: 72 HVVRYFSAWAE--DDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLR 129 Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKK------------------LRLIDWGLAEFYHPAQE 188 Y HS ++H D+KP N+ I ++ D G Q Sbjct: 130 YIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ- 188 Query: 189 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 V F E+L + + D+++L + EP N DQ I Sbjct: 189 --VEEGDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPL---PRNGDQWHEI-- 240 Query: 249 VLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRY 308 ++ + P +S E +LL ++ Sbjct: 241 -----------RQGRLPRIPQV-----------------------LSQEFTELLKVMIHP 266 Query: 309 DHQQRLTAKEAMEH 322 D ++R +A ++H Sbjct: 267 DPERRPSAMALVKH 280 >4TN6-A nrPDB Length = 318 Score = 133 bits (334), Expect = 1e-31, Method: Composition-based stats. Identities = 54/253 (21%), Positives = 105/253 (41%), Gaps = 25/253 (9%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRGGTNI 95 + Y+L RK+G G + +++ +I E V +K L+ VK K ++ E KI + ++GG I Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHIESKIYKMMQGGVGI 65 Query: 96 --IKLIDTVKDPVSKTPALVFEYINNTD---FKQLYQILTDFDIRFYMYELLKALDYCHS 150 I+ D +V E + + F + + + +++ ++Y HS Sbjct: 66 PTIRWCGAEGD----YNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHS 121 Query: 151 KGIMHRDVKPHNVM--IDHQQKKLRLIDWGLAEFYHPAQEY--------NVRVASRYFKG 200 K +HRDVKP N + + + + +ID+GLA+ Y A+ + + + Sbjct: 122 KNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYAS 181 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPF--FHGQDNYDQLVRIAKVLGTEELYGY 258 + + D+ SLG +L P+ + RI++ + + Sbjct: 182 INTHLGIEQ-SRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL 240 Query: 259 LKKYHIDLDPHFN 271 K Y + + N Sbjct: 241 CKGYPSEFATYLN 253 >5J0A-A nrPDB Length = 300 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 54/307 (17%), Positives = 102/307 (33%), Gaps = 48/307 (15%) Query: 42 LVRKLGRGKYSEVFEAINITNNE---RVVVKILKP--------VKKKKIKREVKILENLR 90 ++KLG G V+ VK + P V +K++ E KIL++L Sbjct: 13 FMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSL- 71 Query: 91 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ--------ILTDFDIRFYMYELL 142 NI+ + + L EY L + I + Sbjct: 72 HHPNIVG-YRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMA 130 Query: 143 KALDYCHS-KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV----RVASRY 197 + L Y H K ++H D+K NV+I + +++ D G++ E + + Sbjct: 131 RGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEP 190 Query: 198 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257 +K E + + + D+++ G L M+ P + ++ D + Sbjct: 191 WKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDK------------ 238 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317 D D ++ I+ E + ++L D + R +A Sbjct: 239 -------TFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAA 291 Query: 318 ---EAME 321 EA+E Sbjct: 292 HIVEALE 298 >5FQD-C nrPDB Length = 341 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 54/203 (26%), Positives = 91/203 (44%), Gaps = 22/203 (10%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-PVKKKKIKREVKILENLRGGTNI-- 95 Y+LVRK+G G + +++ AINITN E V VK+ + ++ E K+ + L+GG I Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPH 79 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTD---FKQLYQILTDFDIRFYMYELLKALDYCHSKG 152 I+ KD LV + + + F + T + +++ ++Y H+K Sbjct: 80 IRWYGQEKD----YNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKN 135 Query: 153 IMHRDVKPHNVM--IDHQQKKLRLIDWGLAEFYHPAQEY--------NVRVASRYFKGPE 202 +HRD+KP N + I KL LID+GLA+ Y + + + Sbjct: 136 FIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASIN 195 Query: 203 LLVDYQMYDYSLDMWSLG-CMLA 224 + + DM SLG ++ Sbjct: 196 AHLGIEQ-SRRDDMESLGYVLMY 217 >2C47-A nrPDB Length = 313 Score = 131 bits (329), Expect = 5e-31, Method: Composition-based stats. Identities = 54/283 (19%), Positives = 115/283 (40%), Gaps = 26/283 (9%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRGGTNII 96 ++++ +K+G G + E+ N+ NE V +K L+P+K + ++ E + + L + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLSATEGVP 63 Query: 97 KLIDTVKDPVSKTPALVFEYINNTD---FKQLYQILTDFDIRFYMYELLKALDYCHSKGI 153 ++ P K A+V E + + F + T + +L+ ++Y H+K + Sbjct: 64 QVY--YFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSL 121 Query: 154 MHRDVKPHNVMI----DHQQKKLRLIDWGLAEFY--------HPAQEYNVRVASRYFKGP 201 ++RDVKP N ++ +Q + +ID+GLA+ Y P +E+ + + Sbjct: 122 IYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSI 181 Query: 202 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 261 + + D+ +LG M + P+ + D L + +G + ++ Sbjct: 182 NTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK--ADTLKERYQKIGDTKRATPIEV 238 Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDK 304 + L R +F + + DL D+ Sbjct: 239 LCENFPEEMATYLRYVRR---LDFFEKPDYDYLRKLFTDLFDR 278 >4BTK-A nrPDB Length = 337 Score = 130 bits (327), Expect = 9e-31, Method: Composition-based stats. Identities = 49/228 (21%), Positives = 106/228 (46%), Gaps = 21/228 (9%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR-EVKILENLRGGTNI 95 +D +++++K+G G + E++EA+++ E V +K+ + K++ + EV +L+ L+G ++ Sbjct: 55 KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHV 114 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKALDYCHS 150 + I ++ K +V + + + L + T ++L++++ HS Sbjct: 115 CRFIGCGRN--EKFNYVVMQ-LQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 171 Query: 151 KGIMHRDVKPHNVM---IDHQQKKLRLIDWGLAEFY-------HPAQEYNVRVASRYFKG 200 G +HRD+KP N + +K ++D+GLA Y P + + + Sbjct: 172 VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYAS 231 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 + +M D+WSL ML + P+ +D +Q+ I + Sbjct: 232 VNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKD-KEQVGMIKE 277 >4NFN-A nrPDB Length = 309 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 49/228 (21%), Positives = 106/228 (46%), Gaps = 21/228 (9%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR-EVKILENLRGGTNI 95 +D +++++K+G G + E++EA+++ E V +K+ + K++ + EV +L+ L+G ++ Sbjct: 20 KDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHV 79 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKALDYCHS 150 + I ++ K +V + + + L + T ++L++++ HS Sbjct: 80 CRFIGCGRN--EKFNYVVMQ-LQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 136 Query: 151 KGIMHRDVKPHNVM---IDHQQKKLRLIDWGLAEFY-------HPAQEYNVRVASRYFKG 200 G +HRD+KP N + +K ++D+GLA Y P + + + Sbjct: 137 VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYAS 196 Query: 201 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248 + +M D+WSL ML + P+ +D +Q+ I + Sbjct: 197 VNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKD-KEQVGMIKE 242 >2CMW-A nrPDB Length = 310 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 57/282 (20%), Positives = 115/282 (40%), Gaps = 27/282 (9%) Query: 41 QLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRG-GTNIIK 97 ++ +K+G G + E+ N+ NE V +K L+P+K + ++ E + + L G + + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLGSAGEGLPQ 61 Query: 98 LIDTVKDPVSKTPALVFEYINNTD---FKQLYQILTDFDIRFYMYELLKALDYCHSKGIM 154 + P K A+V E + + F + T + +LL ++Y HSK ++ Sbjct: 62 VY--YFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLI 119 Query: 155 HRDVKPHNVMI----DHQQKKLRLIDWGLAEFY--------HPAQEYNVRVASRYFKGPE 202 +RDVKP N +I + ++ + +ID+GLA+ Y P +E+ + + Sbjct: 120 YRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN 179 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262 + + D+ +LG M + P+ + D L + +G + ++ Sbjct: 180 THLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK--ADTLKERYQKIGDTKRNTPIEAL 236 Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDK 304 + L R +F + + DL +K Sbjct: 237 CENFPEEMATYLRYVRR---LDFFEKPDYEYLRTLFTDLFEK 275 >2PZI-A nrPDB Length = 681 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 59/265 (22%), Positives = 110/265 (41%), Gaps = 31/265 (11%) Query: 39 DYQLVRKLGRGKYSEVFEAINIT-NNERVVVKIL----------KPVKKKKIKREVKILE 87 Y++ + G ++ A++ N VV+K L + +++ EV Sbjct: 81 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV--- 137 Query: 88 NLRGGTNIIKLIDTVKD---PVSKTPALVFEYINNTDFKQLY-QILTDFDIRFYMYELLK 143 +I+++ + V+ +V EY+ K+ Q L + Y+ E+L Sbjct: 138 ----HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILP 193 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 AL Y HS G+++ D+KP N+M+ +Q L+LID G + + F+ PE+ Sbjct: 194 ALSYLHSIGLVYNDLKPENIMLTEEQ--LKLIDLGAVSRINSFGYLY---GTPGFQAPEI 248 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 + + D++++G LA++ P +G+ D L VL T + YG L + Sbjct: 249 VRTGP--TVATDIYTVGRTLAAL-TLDLPTRNGR-YVDGLPEDDPVLKTYDSYGRLLRRA 304 Query: 264 IDLDPHFNDILGQHSRKRWENFIHS 288 ID DP + + + Sbjct: 305 IDPDPRQRFTTAEEMSAQLTGVLRE 329 >5VDK-A nrPDB Length = 297 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 48/315 (15%), Positives = 101/315 (32%), Gaps = 79/315 (25%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK-----KIKREVKILENLRG 91 + ++ V K+G G++ V++ I + +K + EV L Sbjct: 14 EKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH 73 Query: 92 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY-------QILTDFDIRFYMYELLKA 144 ++++ + + + EY N + + ++ + ++ Sbjct: 74 HPHVVRYYSSWAE--DDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLG 131 Query: 145 LDYCHSKGIMHRDVKPHNVMIDHQQKK----------------------LRLIDWGLAEF 182 L+Y H+ ++H D+KP N+ I H+ + ++ D G A Sbjct: 132 LNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATS 191 Query: 183 YHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQ 242 + + V F E+L + + D+++LG Sbjct: 192 IN---KPKVEEGDSRFLANEILQEDYRHLPKADIFALGLT-------------------- 228 Query: 243 LVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLL 302 IA G E L +H +F D+ + +S LL Sbjct: 229 ---IAVAAGAESLPTNGAAWHHIRKGNFPDVPQE-----------------LSESFSSLL 268 Query: 303 DKLLRYDHQQRLTAK 317 +++ D +QR +A Sbjct: 269 KNMIQPDAEQRPSAA 283 >4Y12-A nrPDB Length = 375 Score = 128 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 59/265 (22%), Positives = 110/265 (41%), Gaps = 31/265 (11%) Query: 39 DYQLVRKLGRGKYSEVFEAINIT-NNERVVVKIL----------KPVKKKKIKREVKILE 87 Y++ + G ++ A++ N VV+K L + +++ EV Sbjct: 120 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV--- 176 Query: 88 NLRGGTNIIKLIDTVKD---PVSKTPALVFEYINNTDFKQLY-QILTDFDIRFYMYELLK 143 +I+++ + V+ +V EY+ K+ Q L + Y+ E+L Sbjct: 177 ----HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILP 232 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL 203 AL Y HS G+++ D+KP N+M+ +Q L+LID G + + F+ PE+ Sbjct: 233 ALSYLHSIGLVYNDLKPENIMLTEEQ--LKLIDLGAVSRINSFGYLY---GTPGFQAPEI 287 Query: 204 LVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYH 263 + + D++++G LA++ P +G+ D L VL T + YG L + Sbjct: 288 VRTGP--TVATDIYTVGRTLAAL-TLDLPTRNGR-YVDGLPEDDPVLKTYDSYGRLLRRA 343 Query: 264 IDLDPHFNDILGQHSRKRWENFIHS 288 ID DP + + + Sbjct: 344 IDPDPRQRFTTAEEMSAQLTGVLRE 368 >3HNG-A nrPDB Length = 360 Score = 125 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 30/171 (17%), Positives = 69/171 (40%), Gaps = 11/171 (6%) Query: 127 QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA 186 + +T D+ Y +++ + +++ S+ +HRD+ N+++ + +++ D+GLA + Sbjct: 194 EPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLS-ENNVVKICDFGLARDIYKN 252 Query: 187 QEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQL 243 +Y + +R + PE + D ++Y D+WS G +L + F G Y + Sbjct: 253 PDYVRKGDTRLPLKWMAPESIFD-KIYSTKSDVWSYGVLLWEI------FSLGGSPYPGV 305 Query: 244 VRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLV 294 ++ + +L R E +E + Sbjct: 306 QMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL 356 Score = 80.4 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 23/104 (22%), Positives = 42/104 (40%), Gaps = 10/104 (9%) Query: 37 QDDYQLVRKLGRGKYSEVFEA-----INITNNERVVVKILKP----VKKKKIKREVKILE 87 ++ +L + LGRG + +V +A V VK+LK + K + E+KIL Sbjct: 26 RERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILT 85 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTD 131 ++ N++ L+ +V EY + + D Sbjct: 86 HIGHHLNVVNLLGACTKQGGPLMVIV-EYCKYGNLSNYLKSKRD 128 >5X18-A nrPDB Length = 295 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 49/280 (17%), Positives = 102/280 (36%), Gaps = 25/280 (8%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-KPVKKKKIKREVKILENLRGGTNIIK 97 Y++ +K+G G + +FE N+ N V +K + + +++ E K + L G NI Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIP- 66 Query: 98 LIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIM 154 LV + + + F + + + +++ ++ H+ ++ Sbjct: 67 -YAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLI 125 Query: 155 HRDVKPHNVMIDHQQ----KKLRLIDWGLAEFYH--------PAQEYNVRVASRYFKGPE 202 +RD+KP N +I + LID+G+A+ Y P +E + + Sbjct: 126 YRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSIN 185 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPF--FHGQDNYDQLVRIAKVLGTEELYGYLK 260 + + DM +LG + + P+ +N + +I + + +Y + Sbjct: 186 THLGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRSTNVYDLAQ 244 Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300 L F L +E E + LD Sbjct: 245 G----LPVQFGRYLEIVRSLSFEECPDYEGYRKLLLSVLD 280 >4NT4-A nrPDB Length = 312 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 56/289 (19%), Positives = 119/289 (41%), Gaps = 32/289 (11%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK--KIKREVKILENLRGG---- 92 ++++ +K+G G + E+ N+ NNE V +K ++P+K K ++ E + + L Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIK-MEPMKSKAPQLHLEYRFYKLLGSHADNA 71 Query: 93 -TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY----QILTDFDIRFYMYELLKALDY 147 I ++ + + A+V E + + L+ + + + +LL ++Y Sbjct: 72 PDGIPRIYH-LGTCGGRYNAMVLELL-GLSLEDLFNICARKFSLKTVLMIAKQLLHRIEY 129 Query: 148 CHSKGIMHRDVKPHNVMI----DHQQKKLRLIDWGLAEFY--------HPAQEYNVRVAS 195 HS+ +++RDVKP N +I ++K + +ID+GLA+ Y P +E+ + Sbjct: 130 VHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGT 189 Query: 196 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEEL 255 + + + D+ +LG M + P+ + D L + +G + Sbjct: 190 ARYMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLK--ADTLKERYQKIGDTKR 246 Query: 256 YGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDK 304 ++ F L R +F + + + DL D+ Sbjct: 247 ATPIEVLCDGHPEEFATYLRYVRR---LDFFETPDYDFLRRLFQDLFDR 292 >3VHK-A nrPDB Length = 368 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 37/198 (18%), Positives = 76/198 (38%), Gaps = 40/198 (20%) Query: 128 ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ 187 LT + Y +++ K +++ S+ +HRD+ N+++ + +++ D+GLA + Sbjct: 196 FLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKN-VVKICDFGLARDIYKDP 254 Query: 188 EYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLV 244 +Y + +R + PE + D ++Y D+WS G +L + + G Sbjct: 255 DYVRKGDARLPLKWMAPETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPG-------- 305 Query: 245 RIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDK 304 + +D F L + +R R ++ E + Sbjct: 306 -------------------VKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLD-------- 338 Query: 305 LLRYDHQQRLTAKEAMEH 322 + QR T E +EH Sbjct: 339 CWHGEPSQRPTFSELVEH 356 Score = 80.0 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 25/101 (24%), Positives = 45/101 (44%), Gaps = 10/101 (9%) Query: 36 NQDDYQLVRKLGRGKYSEVFEA----INIT-NNERVVVKILKP----VKKKKIKREVKIL 86 +D +L + LGRG + +V EA I+ T V VK+LK + + + E+KIL Sbjct: 27 PRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKIL 86 Query: 87 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ 127 ++ N++ L+ P +V E+ + + Sbjct: 87 IHIGHHLNVVNLLGACTKPGGPLMVIV-EFCKFGNLSTYLR 126 >4RT7-A nrPDB Length = 415 Score = 123 bits (310), Expect = 9e-29, Method: Composition-based stats. Identities = 40/162 (24%), Positives = 68/162 (41%), Gaps = 17/162 (10%) Query: 81 REVKILENLRGGTNIIKLID-TVKDPVSKTPALVFEYINNTDFKQL--YQILTDFDIRFY 137 REV+I I L + EY N ++ +LT D+ + Sbjct: 198 REVQIH---PDSDQISGLHGNSFHSEDE------IEYENQKRLEEEEDLNVLTFEDLLCF 248 Query: 138 MYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY 197 Y++ K +++ K +HRD+ NV++ H K +++ D+GLA Y VR +R Sbjct: 249 AYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKICDFGLARDIMSDSNYVVRGNARL 307 Query: 198 ---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHG 236 + PE L + +Y D+WS G +L + + G Sbjct: 308 PVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVNPYPG 348 Score = 92.3 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 24/118 (20%), Positives = 49/118 (41%), Gaps = 15/118 (12%) Query: 24 YWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAI-----NITNNERVVVKILK----PV 74 +D + P +++ + + LG G + +V A + +V VK+LK Sbjct: 55 EYDLKWEFP----RENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS 110 Query: 75 KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDF 132 +++ + E+K++ L NI+ L+ +S L+FEY D + + Sbjct: 111 EREALMSELKMMTQLGSHENIVNLLGAC--TLSGPIYLIFEYCCYGDLLNYLRSKREK 166 >5M07-A nrPDB Length = 276 Score = 121 bits (303), Expect = 6e-28, Method: Composition-based stats. Identities = 43/207 (20%), Positives = 83/207 (40%), Gaps = 31/207 (14%) Query: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK------KKKIKREVKILENLRGGT 93 Y +VR LG EV+ + +K+L P +++ +RE ++ L Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFH-P 90 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKALDYC 148 +I+++ D + + +Y++ D Q +L ++ + + ALDY Sbjct: 91 HILEVHD--RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYA 148 Query: 149 HSKGIMHRDVKPHNVMIDHQ---QKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV 205 H +G++HRDV P NV++ Q +++ L D+G+A + PEL Sbjct: 149 HQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPELSA 195 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREP 232 + D ++L + P Sbjct: 196 GADVDG-RADQYALALTAIHLFAGAPP 221 >6BFN-A nrPDB Length = 342 Score = 121 bits (303), Expect = 6e-28, Method: Composition-based stats. Identities = 40/212 (18%), Positives = 73/212 (34%), Gaps = 33/212 (15%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKILKPVK-------KKKIKREVKILENLRGGTNIIK 97 K+G G + V+ A+ VK LK K+ EV+ L R NI+ Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRH-PNIVD 85 Query: 98 LIDTVKDPVSKTPALVFEYINNTDFKQLYQ-------ILTDFDIRFYMYELLKALDYCH- 149 + LV+ ++ N + L+ + +A+ + H Sbjct: 86 FAGYC--AQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQ 143 Query: 150 -SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF----------YHPAQEYNVRVASRYF 198 S ++H D+K NV++D + +L D+GLA F + + Sbjct: 144 DSPSLIHGDIKSSNVLLDERLTP-KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAY 202 Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRR 230 PE + D +S G ++ + + Sbjct: 203 L-PEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >4JRN-A nrPDB Length = 372 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 60/326 (18%), Positives = 101/326 (30%), Gaps = 104/326 (31%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKILKPVKKK------KIKREVKILENLRGGTNIIKL 98 LG G ++ V+EA ++ NE + VK+ K+ ++RE N L Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFS-------L 127 Query: 99 IDTVKDPVSKTPALV----------------------------FEYINNTD--------- 121 T KD +V F + + Sbjct: 128 AKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISW 187 Query: 122 -FKQLYQILTDFDIRFYMY---ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDW 177 F ++F + MY + +K + ++GI+H D+KP N ++ + +L L D+ Sbjct: 188 VFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLL-LKDGRLFLGDF 246 Query: 178 GLAEFYHPAQEYNVRVASRYFKGPELLVDYQM--YDYSLDMWSLGCMLASMIFRREPFFH 235 G Y + + ++ PE Y + D W LG L + + P Sbjct: 247 G---TYRINNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP--T 301 Query: 236 GQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS 295 D + A T EL Sbjct: 302 PADGIWDYLHFADCPSTPELVQ-------------------------------------- 323 Query: 296 PEALDLLDKLLRYDHQQRLTAKEAME 321 DL+ LL D Q+R+ +A+E Sbjct: 324 ----DLIRSLLNRDPQKRMLPLQALE 345 >4XHH-A nrPDB Length = 403 Score = 114 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 46/288 (15%), Positives = 109/288 (37%), Gaps = 36/288 (12%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-PVKKKKIKREVKILENLRGGTNI-- 95 +++ RK+G G + +++ N+ + E V +++ + ++ E ++ + L GG I Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKYLSGGVGIPF 67 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTD---FKQLYQILTDFDIRFYMYELLKALDYCHSKG 152 I+ + A+V + + + F ++ + + +++ + Y H + Sbjct: 68 IRWFG----REGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGRS 123 Query: 153 IMHRDVKPHNVM--IDHQQKKLRLIDWGLAEFYHPAQEY--------NVRVASRYFKGPE 202 +HRD+KP N + + + + +ID+GL++ Y + + + Sbjct: 124 FIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVN 183 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPF-----FHGQDNYDQLVRIAKVLGTEELYG 257 + + D+ SLG ML P+ + YD+++ + E L Sbjct: 184 THLGIEQ-SRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCISVETLCA 242 Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKL 305 L + + ++ F + ++ DL KL Sbjct: 243 GLPLEFSEYMNYCRNL----------KFDERPDYLYLARLFKDLSIKL 280 >1CSN-A nrPDB Length = 298 Score = 113 bits (284), Expect = 9e-26, Method: Composition-based stats. Identities = 40/211 (18%), Positives = 90/211 (42%), Gaps = 19/211 (9%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-KPVKKKKIKREVKILENLRGGTNIIK 97 Y++ R++G G + +FE N+ NN++V +K + +++ E + + L G T I Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPN 70 Query: 98 LIDTVKDPVSKTPALVFEYINNT--DFKQLY-QILTDFDIRFYMYELLKALDYCHSKGIM 154 + ++ + LV + + + D L + + + ++L + H K ++ Sbjct: 71 VYYFGQEGLHN--VLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLV 128 Query: 155 HRDVKPHNVMIDHQQKK----LRLIDWGLAEFYH--------PAQEYNVRVASRYFKGPE 202 +RD+KP N +I K + ++D+G+ +FY P +E + + Sbjct: 129 YRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMSIN 188 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 + + D+ +LG + + P+ Sbjct: 189 THLGREQ-SRRDDLEALGHVFMYFLRGSLPW 218 >4XHL-A nrPDB Length = 394 Score = 111 bits (278), Expect = 5e-25, Method: Composition-based stats. Identities = 35/211 (16%), Positives = 85/211 (40%), Gaps = 21/211 (9%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-PVKKKKIKREVKILENLRGGTNI-- 95 +++ RK+G G + +++ N+ + E V +++ + ++ E ++ L GG I Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSGGVGIPF 67 Query: 96 IKLIDTVKDPVSKTPALVFEYINNTD---FKQLYQILTDFDIRFYMYELLKALDYCHSKG 152 I+ + A+V + + + F ++ + + ++ + Y H + Sbjct: 68 IRWFG----REGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRS 123 Query: 153 IMHRDVKPHNVM--IDHQQKKLRLIDWGLAEFYHPAQEY--------NVRVASRYFKGPE 202 +HRD+KP N + + + + +ID+GL++ Y + + + Sbjct: 124 FIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVN 183 Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPF 233 + + D+ SLG +L P+ Sbjct: 184 THLGIEQ-SRRDDLESLGYVLIYFCKGSLPW 213 >4MWI-A nrPDB Length = 294 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 45/276 (16%), Positives = 95/276 (34%), Gaps = 58/276 (21%) Query: 66 VVVKILKPVK-------KKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTP--ALVFEY 116 V +K+ K ++ ++ +E+K ++ NI+++ D P ++V EY Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFES-PNILRIFGICIDETVTPPQFSIVMEY 108 Query: 117 INNTDFKQLYQILTDFDIRFYMYELL---KALDYCHSKGI--MHRDVKPHNVMIDHQQKK 171 ++L D + M +L + L H +H ++ N ++ Q + Sbjct: 109 CELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVT-QGYQ 167 Query: 172 LRLIDWGLAE-----FYHPAQEYNVRVASRYFKGP-ELLVDYQMYDYSLDMWSLGCMLAS 225 ++L + L + +E RV S + P EL + YD +++S G +L Sbjct: 168 VKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWE 227 Query: 226 MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENF 285 + PF +I K++ + L Sbjct: 228 IATGDIPFQGCNSE-----KIRKLVAVKRQQEPLG------------------------- 257 Query: 286 IHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 E +++D+ +D R + E ++ Sbjct: 258 ------EDCPSELREIIDECRAHDPSVRPSVDEILK 287 >5UV4-A nrPDB Length = 311 Score = 106 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 38/202 (18%), Positives = 81/202 (40%), Gaps = 17/202 (8%) Query: 44 RKLGRGKYSEVFEAINITNNERVVVKILKP---VKKKKIKREVKILENLRGGTNIIKLID 100 +GR + ++A + N + VK LK KK+ RE+K L ++R N++ L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSKKEFSREIKKLGSVRH-PNLVPLRG 88 Query: 101 TVKDPVSKTPALVFEYINNTDFKQLYQILTDFDI--------RFYMYELLKALDYCHSKG 152 P ++ +Y + T + ++ ++ + LDY H++ Sbjct: 89 YYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNER 148 Query: 153 IM-HRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP--AQEYNVRVASRYFKGPELLVDYQM 209 ++ H ++K NV+I + + D+ L P E + + + PE + Sbjct: 149 VIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSKP 208 Query: 210 Y-DYSLDMWSLGCMLASMIFRR 230 D+++ G +L ++ + Sbjct: 209 CPSLKSDVYAFGVILLELLTGK 230 >5X1R-A nrPDB Length = 302 Score = 104 bits (260), Expect = 6e-23, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 87/239 (36%), Gaps = 35/239 (14%) Query: 26 DYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK------- 78 +PS +++++ +G G + V+ A + + +K P K Sbjct: 9 PNSNSLPSGYRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSI 68 Query: 79 -----------------IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD 121 +E ++L ++ ++ ++ + T + ++ + T Sbjct: 69 GLRGERFGKTFQAGLNSFIQEARLLARF-SHPGLLHVLRFWEE--NGTAYMGTQFYSGTT 125 Query: 122 FKQLY----QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDW 177 K L + + + IR + L A++ H +G +HRD+ N+ I Q + L+D+ Sbjct: 126 LKNLQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPV-LLDF 184 Query: 178 GLAE-FYHPAQEYNVRVASRYFKGPELLVDYQM--YDYSLDMWSLGCMLASMIFRREPF 233 G A + V F E + D+++LG +L ++I P Sbjct: 185 GSARKEIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPPP 243 >4M69-B nrPDB Length = 283 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 39/253 (15%), Positives = 92/253 (36%), Gaps = 25/253 (9%) Query: 66 VVVKILKPVKKK-------KIKREVKILENLRGGTNIIKLIDTVKDPVSKTP--ALVFEY 116 V +K+ + + E+K ++ NI+++ D K P ++V EY Sbjct: 35 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKF-DSPNILRIFGICIDQTVKPPEFSIVMEY 93 Query: 117 INNTDFKQLYQI---LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLR 173 ++L LT + + L H +HR++ + ++ +++ Sbjct: 94 CELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLV-AGGYQVK 152 Query: 174 LIDWGLAEFYHPAQEYN-----VRVASRYFKGPELLVD-YQMYDYSLDMWSLGCMLASMI 227 L + L++ + R +S + PE L + + +YD +++S G +L + Sbjct: 153 LAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIA 212 Query: 228 FRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIH 287 + PF +I +++ ++ + + +L + H + + Sbjct: 213 TGKIPFEGCDS-----KKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDG 267 Query: 288 SENRHLVSPEALD 300 R E+ D Sbjct: 268 ILERLSAVEESTD 280 >4BTF-A nrPDB Length = 469 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 39/253 (15%), Positives = 92/253 (36%), Gaps = 25/253 (9%) Query: 66 VVVKILKPVKKK-------KIKREVKILENLRGGTNIIKLIDTVKDPVSKTP--ALVFEY 116 V +K+ + + E+K ++ NI+++ D K P ++V EY Sbjct: 221 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKF-DSPNILRIFGICIDQTVKPPEFSIVMEY 279 Query: 117 INNTDFKQLYQI---LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLR 173 ++L LT + + L H +HR++ + ++ +++ Sbjct: 280 CELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLV-AGGYQVK 338 Query: 174 LIDWGLAEFYHPAQEYN-----VRVASRYFKGPELLVD-YQMYDYSLDMWSLGCMLASMI 227 L + L++ + R +S + PE L + + +YD +++S G +L + Sbjct: 339 LAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIA 398 Query: 228 FRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIH 287 + PF +I +++ ++ + + +L + H + + Sbjct: 399 TGKIPFEGCDS-----KKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDG 453 Query: 288 SENRHLVSPEALD 300 R E+ D Sbjct: 454 ILERLSAVEESTD 466 >4L00-A nrPDB Length = 304 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 50/301 (16%), Positives = 94/301 (31%), Gaps = 64/301 (21%) Query: 56 EAINITNNERVVVKILKPVKKKKIKR--EVKILENLRGGTNIIKLIDTVKDPVSKTPALV 113 E + +V++K+L P + E + +I+ L V +V Sbjct: 53 EGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENI--MV 110 Query: 114 FEYINNTDFKQLYQ----ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ 169 E++ +LT +L AL Y K ++H +V N+++ + Sbjct: 111 EEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREG 170 Query: 170 KK------LRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 223 ++L D G+ QE R+ + PE + D + + D WS G L Sbjct: 171 IDSECGPFIKLSDPGIPITVLSRQECIERI---PWIAPECVEDSKNLSVAADKWSFGTTL 227 Query: 224 ASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWE 283 + + E + L + Y P Sbjct: 228 WEICYNGEIPLKDKT----------------LIEKERFYESRCRPVTPSCK--------- 262 Query: 284 NFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLS 343 E DL+ + + YD QR P+F ++++ ++ N + Sbjct: 263 -------------ELADLMTRCMNYDPNQR---------PFFRAIMRDINKLEEQNPDIV 300 Query: 344 S 344 S Sbjct: 301 S 301 >4IX6-A nrPDB Length = 350 Score = 98.5 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 59/337 (17%), Positives = 107/337 (31%), Gaps = 81/337 (24%) Query: 45 KLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKRE--VKILENLRGGTN------II 96 LG G + VF + + + V LK K + E ++ ++ + Sbjct: 27 PLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYHVHANAKGTCA 82 Query: 97 KLIDTVK-----------DPVSKTPALVF--------EYINNTDFKQLYQILTDFDI--- 134 + + ++ +++ L++ E + L + D Sbjct: 83 RFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATEL 142 Query: 135 ---RFYMYELLKALDYCHSKGIMHRDVKPHN-VMIDHQQKKLRLIDWGLAEFYHPAQEY- 189 + M ELL +L H G++HRDVKP N + + L+LID G A P E Sbjct: 143 GVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETL 202 Query: 190 -----NVRVASRYFKGPELLVDYQMYDYSL----------------DMWSLGCMLASMIF 228 + RY K EL + D WS GC++ + Sbjct: 203 NYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLAV 262 Query: 229 RREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHS 288 V + G E K D++ + G++ + + Sbjct: 263 ---------------VGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDAN 307 Query: 289 ENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 DL +L+ + R + + A+ H +F Sbjct: 308 GGA------GWDLCQRLMEAERDARASCEAALSHAFF 338 >5OAT-A nrPDB Length = 411 Score = 97.3 bits (241), Expect = 8e-21, Method: Composition-based stats. Identities = 43/344 (12%), Positives = 100/344 (29%), Gaps = 103/344 (29%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNER-----VVVK-------------ILKPVKKKKI 79 +D L + + +G V+ A + +K ILK + ++ + Sbjct: 11 NDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETV 70 Query: 80 KR------------EVKIL---ENLRGGTNIIKLIDTVKDPV---------------SKT 109 E+++ ++L NI+ + D + + Sbjct: 71 PARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMS 130 Query: 110 PALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ 169 L+ + + L + + +LL+ + + + GI HRD+K N+++D + Sbjct: 131 LFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSE 190 Query: 170 KK---LRLIDWGLAEFYHP-------AQEYNVRVASRYFKGPELLVDYQM------YDYS 213 + L + D+G + + PE++ Y Sbjct: 191 PESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYS-K 249 Query: 214 LDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDI 273 D+W++G + + PF+ Sbjct: 250 ADLWAVGAIAYEIFNCHNPFYGPS------------------------------------ 273 Query: 274 LGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317 + ++ + V L+ LL+ + +RL + Sbjct: 274 --RLKNFNYKEGDLPKLPDEVPTVIQALVANLLKRNPNKRLDPE 315 >5USZ-A nrPDB Length = 289 Score = 96.2 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 29/214 (13%), Positives = 76/214 (35%), Gaps = 27/214 (12%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNE-------RVVVKILKPVKK---KKIKREVKILE 87 +D LG+G ++++F+ + + V++K+L + + ++ Sbjct: 8 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMS 67 Query: 88 NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLK 143 L +++ LV E++ + + +L Sbjct: 68 KL-SHKHLVLNYGVC--VCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAA 124 Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKK-------LRLIDWGLAEFYHPAQEYNVRVASR 196 A+ + ++H +V N+++ ++ + ++L D G++ P R+ Sbjct: 125 AMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI--- 181 Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRR 230 + PE + + + + + D WS G L + Sbjct: 182 PWVPPECIENPKNLNLATDKWSFGTTLWEICSGG 215 >6EQI-C nrPDB Length = 433 Score = 93.1 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 49/331 (14%), Positives = 107/331 (32%), Gaps = 95/331 (28%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAI--NITNNE---RVVVKIL--------KPVKKKKIKR 81 N D+ L + +G + V+ A N+ +N+ ++ VK++ K + R Sbjct: 12 ANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYR 71 Query: 82 E------------------VKILE-NLRGGTNIIKLIDTVKDPV---------------- 106 E + + L NI+++ D + Sbjct: 72 ETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPP 131 Query: 107 ---------SKTPALVF--------EYINNTDFKQLYQILTDFDIRFYMYELLKALDYCH 149 + + LV EY+ + + + +LL+A+ + + Sbjct: 132 RINPEGSGRNMSLFLVMKRYDCTLKEYLRD-------KTPNMRSSILLLSQLLEAVAHMN 184 Query: 150 SKGIMHRDVKPHNVMIDHQQK----KLRLIDWGLAEFYHPA-------QEYNVRVASRYF 198 I HRD+K N+++D + + + D+G E + +R Sbjct: 185 IHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRAL 244 Query: 199 KGPELLVDYQM------YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT 252 PE+ Y D+W++G + + PF+ + ++K Sbjct: 245 MAPEIANAKPGTFSWLNY-KKSDLWAVGAIAYEIFNIDNPFYD-----KTMKLLSKSYKE 298 Query: 253 EELYGYLKKYHIDLDPHFNDILGQHSRKRWE 283 E+L + +++L + + KR + Sbjct: 299 EDLPELPDTIPFIIRNLVSNMLSRSTNKRLD 329 >3REP-A nrPDB Length = 271 Score = 92.7 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 37/210 (17%), Positives = 79/210 (37%), Gaps = 24/210 (11%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-----PVKKKKIKREVKILENLRGGT 93 + KL E+++ +VVK+LK K + E L + Sbjct: 11 QLNFLTKLNENHSGELWKGRW--QGNDIVVKVLKVRDWSTRKSRDFNEECPRLR-IFSHP 67 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ-----ILTDFDIRFYMYELLKALDYC 148 N++ ++ + P + P L+ ++ + ++ + ++ + + + Sbjct: 68 NVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFL 127 Query: 149 HS-KGIMHR-DVKPHNVMIDHQ-QKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV 205 H+ + ++ R + +VMID ++ + D + F P + Y + + PE L Sbjct: 128 HTLEPLIPRHALNSRSVMIDEDMTARISMADVKFS-FQSPGRMY-----APAWVAPEALQ 181 Query: 206 DYQMYD--YSLDMWSLGCMLASMIFRREPF 233 S DMWS +L ++ R PF Sbjct: 182 KKPEDTNRRSADMWSFAVLLWELVTREVPF 211 >5CLR-A nrPDB Length = 451 Score = 90.4 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 33/192 (17%), Positives = 72/192 (37%), Gaps = 23/192 (11%) Query: 55 FEAINITNNERVVVK--ILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPAL 112 F+ + + + +K + + E L L +L+ T + ++ + Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLTEFTNEKDTLSKLG------RLVGTFFNEQTQVHYI 149 Query: 113 VFEYINNTDFKQLYQILTD-------FDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMI 165 + +I D + L +++ M + + H G++HRD+KP N+M+ Sbjct: 150 LTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIML 209 Query: 166 DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPEL--LVDYQMYDYSLDMWSLGCML 223 D + L+D+G + + + + PEL D+ + D+++L Sbjct: 210 DA-DMQCHLVDFGSSS--SDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFAL---A 263 Query: 224 ASMIFRREPFFH 235 S+ PF Sbjct: 264 YSLDELFNPFRQ 275 >6J6I-B nrPDB Length = 351 Score = 87.3 bits (215), Expect = 9e-18, Method: Composition-based stats. Identities = 35/174 (20%), Positives = 69/174 (39%), Gaps = 18/174 (10%) Query: 72 KPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL------ 125 K + K++ ++ + + +N ++L+ + P LVFE+ + Q Sbjct: 97 KRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLE--FPFPVLVFEFAEHGAMNQRGGVIVN 154 Query: 126 -YQILTDFDIRF-YMYELLKALDYCHS---KGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180 + L + +R E+ A+ Y H+ K I+HRDVKP +V +D + +L D + Sbjct: 155 GEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLD-KNWTAKLSDLSFS 213 Query: 181 EFYHPAQEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRRE 231 + + + + P L D++S G L +I + Sbjct: 214 ISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGICLLVIITGKP 266 >4CI6-B nrPDB Length = 643 Score = 85.4 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 49/309 (15%), Positives = 106/309 (34%), Gaps = 52/309 (16%) Query: 58 INITNNERVVVKILKPVKKKKIKREVKILENL----RGGTNIIKLIDTVKDPVSKTPA-- 111 I + +R+V KI + + + + E++ +++ N+ + P Sbjct: 63 IETKDKQRLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYA 122 Query: 112 LVFEYINNTDFKQLYQILTDF-------------DIRFYMYELLKALDYCHSKGIMHRDV 158 L+ + ++ + L D I+F + LL ++ GI+H D+ Sbjct: 123 LLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDI 182 Query: 159 KPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS 218 KP NV+ D + +ID GL H + + FK PEL V D++ Sbjct: 183 KPGNVVFDRASGEPVVIDLGL----HSRSGEQPKGFTESFKAPELGVGNLGASEKSDVF- 237 Query: 219 LGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHS 278 ++++++ E F + + + + +E + + + P + ++ Sbjct: 238 --LVVSTLLHGIEGFEKDPEIKP--NQGLRFITSEPAHVMDENGYPIHRPGIAGVETAYT 293 Query: 279 RKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCAD 338 R + +L R + EA H + ++ + Sbjct: 294 R---------------------FITDILGVSADSRPDSNEARLHEFLSDGTIDEE---SA 329 Query: 339 NAVLSSGLT 347 +L LT Sbjct: 330 KQILKDTLT 338 >5C01-A nrPDB Length = 342 Score = 83.5 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 41/278 (14%), Positives = 78/278 (28%), Gaps = 56/278 (20%) Query: 57 AINITNNERVVVKILKPVKKKKIKR--EVKILENLRGGTNIIKLIDTVKDPVSKTPALVF 114 + RVV+K+L P E L + T++ + +V Sbjct: 101 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENI--MVT 158 Query: 115 EYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDH--- 167 EY+ + + + +L AL Y +K ++H +V N+++ Sbjct: 159 EYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGL 218 Query: 168 ---QQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY-QMYDYSLDMWSLGCML 223 ++L D G+ +E R+ + PE L ++D W G L Sbjct: 219 AEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATL 275 Query: 224 ASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWE 283 + F E + + HF + Sbjct: 276 LEICFDGEAPLQSRSPSE-------------------------KEHFYQRQHRLPEPSCP 310 Query: 284 NFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 L + L Y+ QR + + + Sbjct: 311 QLAT-------------LTSQCLTYEPTQRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 83.5 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 41/278 (14%), Positives = 78/278 (28%), Gaps = 56/278 (20%) Query: 57 AINITNNERVVVKILKPVKKKKIKR--EVKILENLRGGTNIIKLIDTVKDPVSKTPALVF 114 + RVV+K+L P E L + T++ + +V Sbjct: 78 GRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENI--MVT 135 Query: 115 EYINNTDFKQLYQI----LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDH--- 167 EY+ + + + +L AL Y +K ++H +V N+++ Sbjct: 136 EYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGL 195 Query: 168 ---QQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY-QMYDYSLDMWSLGCML 223 ++L D G+ +E R+ + PE L ++D W G L Sbjct: 196 AEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATL 252 Query: 224 ASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWE 283 + F E + + HF + Sbjct: 253 LEICFDGEAPLQSRSPSE-------------------------KEHFYQRQHRLPEPSCP 287 Query: 284 NFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321 L + L Y+ QR + + + Sbjct: 288 QLAT-------------LTSQCLTYEPTQRPSFRTILR 312 >5DMZ-A nrPDB Length = 365 Score = 83.5 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 42/243 (17%), Positives = 96/243 (39%), Gaps = 40/243 (16%) Query: 25 WDYEAHVPSWGNQDDYQLVRKL-------GRGKYSEVFEAI-----NITNNERVVVKILK 72 ++++ +P+ + ++QL KL G G +++V+EA + N ++ V+K+ K Sbjct: 45 FEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQK 104 Query: 73 PVKKKKIKREVKILENLR---GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY--- 126 P + +++E L+ +K LV E + Sbjct: 105 PANPWEFYIGTQLMERLKPSMQHMF-MKFYSA--HLFQNGSVLVGELYSYGTLLNAINLY 161 Query: 127 -----QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMI----------DHQQKK 171 +++ + + +L ++ H I+H D+KP N ++ D Sbjct: 162 KNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAG 221 Query: 172 LRLIDWGLA---EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 228 L LID G + + + + + + F+ E+L + + ++Y +D + + + M+F Sbjct: 222 LALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSN-KPWNYQIDYFGVAATVYCMLF 280 Query: 229 RRE 231 Sbjct: 281 GTY 283 >4L68-A nrPDB Length = 340 Score = 83.5 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 39/192 (20%), Positives = 77/192 (40%), Gaps = 20/192 (10%) Query: 52 SEVFEAINITNNERVVVKILKPVK--KKKIKREVKILENLRGGTNIIKLIDTVKDPVSKT 109 ++A+ + + + VK L K +++ + E+ L LR N+ L+ V + Sbjct: 54 GTTYKAL-LPDGSALAVKHLSTCKLGEREFRYEMNQLWELRHS-NLAPLLGFC--VVEEE 109 Query: 110 PALVFEYINNTDFKQLY---QILTDFDIRF-YMYELLKALDYCHS---KGIMHRDVKPHN 162 LV++Y++N L + D+ RF + L + H I+H+++ Sbjct: 110 KFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSV 169 Query: 163 VMIDHQQKKLRLIDWGLAEFYHPAQE-----YNVRVASRYFKGPELLVDYQMYDYSLDMW 217 ++ID + R+ID GLA P+ + + PE + D++ Sbjct: 170 ILID-EDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPE-YSTTMLASLKGDVY 227 Query: 218 SLGCMLASMIFR 229 LG +L + Sbjct: 228 GLGVVLLELATG 239 >6G4J-A nrPDB Length = 315 Score = 81.9 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 50/270 (18%), Positives = 103/270 (38%), Gaps = 18/270 (6%) Query: 36 NQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNI 95 N + Y L ++LG+G V+ A T++ V +K+ I EV +L++ ++ Sbjct: 24 NGNTYTLRKQLGKGANGIVYLAE--TSDGHVALKV--SDDSLSITSEVNVLKSFSKAQSV 79 Query: 96 ---IKLIDT----VKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYC 148 DT + +K EYI + I M +LL +L Sbjct: 80 TMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVL 139 Query: 149 HSKGIMHRDVKPHNVMIDHQQKKLRLIDW-GLAEFYHPAQEYNVRVASRYFKGPELLVDY 207 H +G + D+KP N+++ ++R ID G + +EY Y+ Sbjct: 140 HQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGYWG-----YGT 194 Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267 + + S D++++ ++ + + ++E F +QL + + + Y ++ D Sbjct: 195 RKAEPSYDLFAVAMIMINSVHKKE-FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGD 253 Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPE 297 D + + + + SP+ Sbjct: 254 YQSADEMKKDMLDAGQKAAQRKQPIKASPQ 283 >5UU1-A nrPDB Length = 324 Score = 78.1 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 35/230 (15%), Positives = 80/230 (34%), Gaps = 36/230 (15%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK--IKREVKILENLRGGTNI 95 + + L +K+G G + ++ A E+ ++K ++ + E+K + + I Sbjct: 16 NQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCI 75 Query: 96 IKLI----------------DTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRF 136 K I + +V E + D +++ + Sbjct: 76 KKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQNGTFKKSTVLQ 134 Query: 137 YMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQK-KLRLIDWGLAEFYHPAQEY------ 189 +L L+Y H +H D+K N+++ ++ ++ L D+GL+ Y P + Sbjct: 135 LGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQEN 194 Query: 190 --NVRVASRYFKGPELLVDYQMY--DYSLDMWSLGCMLASMIFRREPFFH 235 + F L ++ D+ LG + + + P+ Sbjct: 195 PRKGHNGTIEFTS---LDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQ 241 >4I94-A nrPDB Length = 300 Score = 78.1 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 48/276 (17%), Positives = 98/276 (35%), Gaps = 60/276 (21%) Query: 53 EVFEAINITNNERVVVKILKPV---KKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKT 109 V++ + N R+ VK ++ E K + LR + L+ + + Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHR-MANLLGCCYEDEER- 100 Query: 110 PALVFEYINNTDFKQLY-----QILTDFDIRFYMYELLKALDYCHSKG-IMHRDVKPHNV 163 L+ E++ N + Q + + +AL+YC SKG ++ D+ + V Sbjct: 101 -LLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRV 159 Query: 164 MIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML 223 + D RL +GL + + Y+ +A F PE L ++ ++S G +L Sbjct: 160 LFDDDANP-RLSCFGLMKNSRDGKSYSTNLA---FTPPEYLRTGRV-TPESVIYSFGTLL 214 Query: 224 ASMIFRRE-PFFHGQD-NYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKR 281 ++ + P H D D+ +++ G E + Sbjct: 215 LDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFS------------------------ 250 Query: 282 WENFIHSENRHLVSPEALDLLD---KLLRYDHQQRL 314 S + +L+ + L+Y+ ++R Sbjct: 251 -------------SDDGTELIRLASRCLQYEPRERP 273 >2RSV-A nrPDB Length = 403 Score = 74.6 bits (182), Expect = 6e-14, Method: Composition-based stats. Identities = 46/306 (15%), Positives = 115/306 (37%), Gaps = 45/306 (14%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERV------VVKILKPVKKKKIKREVKILENLR 90 + ++++ +G+G + ++ A ++ ++E V VVK+ +P + E+K + Sbjct: 41 KKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKV-EPSDNGPLFTELKFYQRAA 98 Query: 91 GGTNI--------IKLIDT-------VKDPVSKTP-ALVFEYINNTDFKQLY----QILT 130 I +K + + D K+ ++ + +D +++Y + + Sbjct: 99 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFS 157 Query: 131 DFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQK-KLRLIDWGLAEFYHPAQEY 189 + +L L+Y H +H D+K N++++++ ++ L+D+GLA Y P + Sbjct: 158 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 217 Query: 190 NVRV--------ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYD 241 + F + D+ LG + + P + Sbjct: 218 KEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLP-WEDNLKDP 275 Query: 242 QLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDL 301 + VR +K+ E + + K + + G+ ++ + + D+ Sbjct: 276 KYVRDSKIRYRENIASLMDKCFPE-----KNKPGEIAKYMETVKLLDYTEKPLYENLRDI 330 Query: 302 LDKLLR 307 L + L+ Sbjct: 331 LLQGLK 336 >2LAV-A nrPDB Length = 361 Score = 73.4 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 46/306 (15%), Positives = 115/306 (37%), Gaps = 45/306 (14%) Query: 37 QDDYQLVRKLGRGKYSEVFEAINITNNERV------VVKILKPVKKKKIKREVKILENLR 90 + ++++ +G+G + ++ A ++ ++E V VVK+ +P + E+K + Sbjct: 34 KKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKV-EPSDNGPLFTELKFYQRAA 91 Query: 91 GGTNI--------IKLIDT-------VKDPVSKTP-ALVFEYINNTDFKQLY----QILT 130 I +K + + D K+ ++ + +D +++Y + + Sbjct: 92 KPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFS 150 Query: 131 DFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQK-KLRLIDWGLAEFYHPAQEY 189 + +L L+Y H +H D+K N++++++ ++ L+D+GLA Y P + Sbjct: 151 RKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVH 210 Query: 190 NVRV--------ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYD 241 + F + D+ LG + + P + Sbjct: 211 KEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLP-WEDNLKDP 268 Query: 242 QLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDL 301 + VR +K+ E + + K + + G+ ++ + + D+ Sbjct: 269 KYVRDSKIRYRENIASLMDKCFPE-----KNKPGEIAKYMETVKLLDYTEKPLYENLRDI 323 Query: 302 LDKLLR 307 L + L+ Sbjct: 324 LLQGLK 329 >4O1O-A nrPDB Length = 717 Score = 69.2 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 30/158 (18%), Positives = 56/158 (35%), Gaps = 13/158 (8%) Query: 25 WDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVK 84 W ++Y++ G ++ + ++ V VK + ++EV Sbjct: 337 WRPMIGKLKIFIDEEYKIADT-AEGG---IYLG--LYEDQEVAVKRFSEGSTRG-QQEVS 389 Query: 85 ILENLRGGTNIIKLIDTVKDPVSKTPALVF-EYINNTDFKQL----YQILTDFDIRFYMY 139 L++ R N++ + D L EY D R + Sbjct: 390 CLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILS 449 Query: 140 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDW 177 L KA+ H G H+D++P N++ID + L D+ Sbjct: 450 SLFKAIGELHRSGYSHQDLQPQNILIDSKNGTF-LADF 486 Score = 31.8 bits (71), Expect = 0.50, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 17/35 (48%), Gaps = 4/35 (11%) Query: 295 SPEALDLLDKLLRY--DHQQRLTAKEAMEHPYFYP 327 E DL+ L + + RL++ + HP+F+ Sbjct: 538 DEETRDLIHHLFHPGDNVEDRLSS--LLAHPFFWS 570 >4AZW-A nrPDB Length = 471 Score = 66.1 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 32/142 (22%), Positives = 53/142 (37%), Gaps = 29/142 (20%) Query: 51 YSE--VFE--AINITNNERVVVKILKPVKKKKIKREVKILEN----------LRGGTNII 96 + E V + ++ + K ++ E+K L L G N Sbjct: 258 FGEDYVCKFFYYDMPHGILTA--EESQRNKHELHNEIKFLTQPPAGFDAPAVLAHGEN-- 313 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHR 156 +++ LV E + + + D + LL++L KG H Sbjct: 314 ----------AQSGWLVMEKLPGRLLSDMLAAGEEIDREKILGSLLRSLAALEKKGFWHD 363 Query: 157 DVKPHNVMIDHQQKKLRLIDWG 178 DV+P NVM+D +Q RLID+G Sbjct: 364 DVRPWNVMVDARQ-HARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 65.4 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 31/142 (21%), Positives = 53/142 (37%), Gaps = 29/142 (20%) Query: 51 YSE--VFE--AINITNNERVVVKILKPVKKKKIKREVKILEN----------LRGGTNII 96 + E V + ++ + K ++ E+K L L G N Sbjct: 258 FGEDYVCKFFYYDMPHGILTA--EESQRNKYELHNEIKFLTQPPAGFDAPAVLAHGEN-- 313 Query: 97 KLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHR 156 +++ LV E + + + D + LL++L +G H Sbjct: 314 ----------AQSGWLVMEKLPGRLLSDMLAAGEEIDREKILGSLLRSLAALEKQGFWHD 363 Query: 157 DVKPHNVMIDHQQKKLRLIDWG 178 DV+P NVM+D +Q RLID+G Sbjct: 364 DVRPWNVMVDARQ-HARLIDFG 384 >2JII-A nrPDB Length = 352 Score = 62.7 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 31/186 (16%), Positives = 66/186 (35%), Gaps = 12/186 (6%) Query: 127 QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQK-KLRLIDWGLAEFYHP 185 +L++ + LL AL++ H +H +V N+ +D + + ++ L +G A Y P Sbjct: 154 HVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCP 213 Query: 186 AQEYNVRV--------ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHG- 236 + ++ V F +L D+ SLG + ++ P+ + Sbjct: 214 SGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP-SRRSDLQSLGYCMLKWLYGFLPWTNCL 272 Query: 237 QDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIH-SENRHLVS 295 + D + + K + + + I L +E + R+ + Sbjct: 273 PNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLE 332 Query: 296 PEALDL 301 DL Sbjct: 333 ALLQDL 338 >4OAU-C nrPDB Length = 699 Score = 61.5 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 25/121 (20%), Positives = 49/121 (40%), Gaps = 8/121 (6%) Query: 63 NERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVF-----EYI 117 + V VK + +REV L++ R ++++ + + E Sbjct: 366 KQEVAVKTF-CEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEAC 424 Query: 118 NNTDFKQLYQILTDFDIRFYMYELLKALDYCH-SKGIMHRDVKPHNVMIDHQQKKLRLID 176 + + + D R + + KA+ H S G H+D++P N++ID + K L D Sbjct: 425 LDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK-KAAHLAD 483 Query: 177 W 177 + Sbjct: 484 F 484 Score = 30.3 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 8/32 (25%), Positives = 14/32 (43%) Query: 295 SPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326 E DL+ +L R + + HP+F+ Sbjct: 536 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFW 567 >6EWX-A nrPDB Length = 484 Score = 58.8 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 41/261 (15%), Positives = 78/261 (29%), Gaps = 81/261 (31%) Query: 131 DFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ--------------------- 169 + + F + +L L++ GI+HRD+ N+++ H Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 170 -------------------KKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 210 +L + ++ A+ + S+ PE++ Q Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY- 327 Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHF 270 D + G ++ ++ + PF E+ L++ Sbjct: 328 -RKFDEFQTGILIYELLHQPNPF--------------------EVRAQLRERDY------ 360 Query: 271 NDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA---MEHPYFYP 327 R E+ L SP L LL D +R+ EA ++ + P Sbjct: 361 ----------RREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQCLLWGP 410 Query: 328 VVKEQSQPCADNAVLSSGLTA 348 + QPC VL + L Sbjct: 411 RRELVEQPCPSEEVLCNTLHN 431 >5GZA-A nrPDB Length = 290 Score = 55.0 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 35/208 (16%), Positives = 63/208 (30%), Gaps = 38/208 (18%) Query: 41 QLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-KKKIKREVKILENLRGGTNIIKLI 99 + V+ +G+G +V+ + ++V + +L + + +L L+ +++ L+ Sbjct: 28 RRVKLIGQGAVKKVYLSEW--QGQKVALSVLSSDQYADDFLHGLSMLRALQSS-HVVTLV 84 Query: 100 DTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIR---FYMYELLKALDYCHSKGIMHR 156 ++ V EY L L R + L A+DY +H Sbjct: 85 GVCEEDA----VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHS 140 Query: 157 DVKPHNVMIDHQQKKLRLIDWGLAEFYH------------PAQEYNVRVA----SRYFKG 200 VM D L + LA V+ + F Sbjct: 141 SPAGIRVMCDSNDLHKTLSQFLLASDMRLLANDLDALPEVEKGGLGVKCGHHELTGDFVA 200 Query: 201 PELL-----------VDYQMYDYSLDMW 217 PE L YD D+W Sbjct: 201 PEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >4CYJ-A nrPDB Length = 438 Score = 54.6 bits (130), Expect = 6e-08, Method: Composition-based stats. Identities = 24/159 (15%), Positives = 59/159 (37%), Gaps = 33/159 (20%) Query: 51 YSE---VFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNI-----IKLIDTV 102 + V++A N N L+ ++ ++ E IL ++ I + + + Sbjct: 65 FGYPSWVYKAQNSRNGRHYA---LRRLEGYRLTNEKAILNVMKDWKKIKNASIVTIHEVF 121 Query: 103 KDPVSKTPALVFEY----INNTDFKQLYQIL-----------TDFDIRFYMYELLKALDY 147 +L+F Y ++ T + +Q + + I Y+ ++ AL Sbjct: 122 TTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKT 181 Query: 148 CHSKGIMHRDVKPHNVMIDHQQK----KLRLID---WGL 179 HS + R ++P +++ + ++D +G+ Sbjct: 182 IHSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGM 220 >5GZ9-A nrPDB Length = 305 Score = 52.3 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 31/215 (14%), Positives = 76/215 (35%), Gaps = 39/215 (18%) Query: 35 GNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVK-KKKIKREVKILENLRGGT 93 + + + ++++G G VF + + +V + L ++ K+ +++L++L+ Sbjct: 31 ELRTEVRQLKRVGEGAVKRVFLSEWKEH--KVALSRLTRLEMKEDFLHGLQMLKSLQS-E 87 Query: 94 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQIL---TDFDIRFYMYELLKALDYCHS 150 +++ L+ ++ + ++ EY L + L D+ + + L A++Y Sbjct: 88 HVVTLVGYCEEDGT----ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSI 143 Query: 151 KGIMH------RDVKPHNVM-------IDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY 197 +H R + N + + + D ++ R Sbjct: 144 INYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRE 203 Query: 198 ----FKGPELLVDYQ-----------MYDYSLDMW 217 F PE L Y Y+ +D+W Sbjct: 204 LHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >6EAS-A nrPDB Length = 308 Score = 51.5 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 33/279 (11%), Positives = 81/279 (29%), Gaps = 53/279 (18%) Query: 55 FEAINITNNERVVV--------KILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPV 106 ++ +++ + V K + + ++++ L + N + L+ ++ Sbjct: 57 YKGT-LSSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKV-SHKNFMNLLGYCEEEH 114 Query: 107 SKTPALVFEYINNTDFKQLYQILTDFDIRFYMY-ELLKALDYC-HSKGIMHRDVKPHNV- 163 T +VFEY N + + + + + + YC + N Sbjct: 115 PFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFD 174 Query: 164 ---MIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLG 220 + ++ D EF++ A+ +N + P++ + Y G Sbjct: 175 STTVYLTDDFAAKVSDL---EFWNDAKGHNSTTNNELAFSPDMEDIVRKY---------G 222 Query: 221 CMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK 280 +L ++ R P + + + +DP +R Sbjct: 223 MVLLEILTGRVPSSEDDGPLENW--------VSRYFEGGMRLEELIDPSIGFFPEDTARA 274 Query: 281 RWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319 E + + D ++R KE Sbjct: 275 LCEV-----------------VRSCIDRDPKKRPQMKEV 296 >6M7Z-A nrPDB Length = 319 Score = 51.5 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 36/249 (14%), Positives = 78/249 (31%), Gaps = 64/249 (25%) Query: 98 LIDTVKDPVSKTPALVFEYINNTDFKQLYQI-LTDFDIRFYMYELLKALDYCHSKGIMHR 156 L+ ++ + +F ++ + + + D++ ++ AL H+ G++HR Sbjct: 109 LLPSLGEYRGAFLTYIFHPLSKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHR 168 Query: 157 DVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYF---KGPEL--------LV 205 ++ N + L GL E + V +F PE+ + Sbjct: 169 SIEL-NSFSVLPDGTVVLG--GLDTAAPIGTETRLWVG--FFGQETAPEIDRNFLADLAL 223 Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265 + D++SLG + ++LG + + Sbjct: 224 TQGRHTVKSDVYSLGV--------------------AFRNLVQLLG-----------NGN 252 Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325 L P + Q + + L K++ + R T +E M+ P F Sbjct: 253 LGPEDRGAVRQDHLELLDK----------------LSQKMIEEEPGNRPTIEEIMKDPLF 296 Query: 326 YPVVKEQSQ 334 + E + Sbjct: 297 EGLNFEDIE 305 >6BHC-A nrPDB Length = 438 Score = 50.3 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 41/287 (14%), Positives = 85/287 (29%), Gaps = 64/287 (22%) Query: 66 VVVKILKPVKKK--KIKREVKILENLRGGTNIIKLIDTV-----------KDPVSKT--- 109 VKI K K+ + + + ++L NI + +DP K Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPSKKQRSH 145 Query: 110 --------PAL-VFEYINNTDFKQLYQI--LTDFDIRFYMYELLKALDYCHSKGIMHRDV 158 P L V +++ + Q + L + + + +L L++ + H D+ Sbjct: 146 VVVITREVPCLTVADFVRD-SLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDL 204 Query: 159 KPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVAS-------------RYF------K 199 + N+++ H Q +G AE + + S Sbjct: 205 RLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSRL 264 Query: 200 GPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYL 259 PE++ Q D + G ++ M+ PF E Sbjct: 265 APEIITATQY--KKCDEFQTGILIYEMLHLPNPFDE---------------NPELKEREY 307 Query: 260 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLL 306 + + P + + + + ++ +A +L LL Sbjct: 308 TRADLPRIPFRSPYSRGLQQLASCLLNPNPSERILISDAKGILQCLL 354 >5VE6-A nrPDB Length = 492 Score = 48.8 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 21/37 (56%) Query: 131 DFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDH 167 + + F + +L L++ GI+HRD+ N+++ H Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVH 243 Score = 34.9 bits (79), Expect = 0.050, Method: Composition-based stats. Identities = 21/123 (17%), Positives = 35/123 (28%), Gaps = 38/123 (30%) Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258 PE++ Q D + G ++ ++ + PF E+ Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPF--------------------EVRAQ 362 Query: 259 LKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKE 318 L++ R E+ L SP L LL D +R+ E Sbjct: 363 LRERDY----------------RQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGE 406 Query: 319 AME 321 A Sbjct: 407 AKR 409 >3ENH-A nrPDB Length = 540 Score = 48.0 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 27/154 (17%), Positives = 62/154 (40%), Gaps = 24/154 (15%) Query: 46 LGRGKYSEVFEAINITNNERVVVK-ILKP----------VKKKKIKREVKILENLRGGTN 94 +G+G +++ + + V++K +K ++K + RE + L ++ Sbjct: 344 IGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDF-G 400 Query: 95 IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIM 154 I + D ++ YIN K + + D Y++ + + H ++ Sbjct: 401 IPAPY--IFDVDLDNKRIMMSYINGKLAKDVIE-----DNLDIAYKIGEIVGKLHKNDVI 453 Query: 155 HRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE 188 H D+ N + D L +ID+GL + + ++ Sbjct: 454 HNDLTTSNFIFDKD---LYIIDFGLGKISNLDED 484 >3Q60-A nrPDB Length = 371 Score = 47.6 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 42/222 (18%), Positives = 77/222 (34%), Gaps = 34/222 (15%) Query: 121 DFKQLYQILTDFDIRFYM-YELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGL 179 DF +++ + +L++ SKG++H P N+ I +L L D + Sbjct: 182 DFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFI-MPDGRLMLGD--V 238 Query: 180 AEFYHPAQEYNVRVASRYFKGPELL-VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQD 238 + + + E L + ++L+ W LG + + PF Sbjct: 239 SALWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF----- 293 Query: 239 NYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEA 298 L T + G K+ + + D L S +F+ + Sbjct: 294 ----------GLVTPGIKGSWKRPSLRVP--GTDSLAFGSCTPLPDFVKT---------- 331 Query: 299 LDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNA 340 L+ + L +D ++RL EAME P F + E S + Sbjct: 332 --LIGRFLNFDRRRRLLPLEAMETPEFLQLQNEISSSLSTGQ 371 >4WWA-A nrPDB Length = 261 Score = 46.1 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 26/162 (16%), Positives = 56/162 (34%), Gaps = 27/162 (16%) Query: 55 FEAINITNNERVVVKILKPVK-----------KKKIKREVKILENLRGGTN--IIKLIDT 101 + ++++ ++K P + K + E ++L L + +LI Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Query: 102 VKDPVSKTPALVF---EYINNTDFKQLYQILTDFD-------IRFYMYELLKALDYCHSK 151 DP + L F + F L L D + + ++ + + H Sbjct: 98 --DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWN 155 Query: 152 GIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNV 191 H D+ N+++ + LID+GL + ++ V Sbjct: 156 DYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKGV 197 >6G38-A nrPDB Length = 357 Score = 46.1 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 33/179 (18%), Positives = 59/179 (32%), Gaps = 58/179 (32%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL----------KPVKK-KKIKREVKIL 86 + Q K+G G + EVF I ++ V +KI+ K ++I E+ I Sbjct: 41 EKLQRCEKIGEGVFGEVF--QTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIIS 98 Query: 87 ENLR----------------GGTNIIK-----LI------------------DTVKDPVS 107 + L + ++ L+ D KD Sbjct: 99 KELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKD--- 155 Query: 108 KTPALVFEY-INNTDFKQLYQILTD-FDIRFYMYELLKALDYCH-SKGIMHRDVKPHNV 163 +V E+ D +Q+ L+ + +++L +L S HRD+ NV Sbjct: 156 DQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >3BYV-A nrPDB Length = 377 Score = 45.7 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 42/226 (18%), Positives = 76/226 (33%), Gaps = 53/226 (23%) Query: 56 EAINITNNERV--------------VVKILKP-VKKKKIKREVKILENLRGGTNIIKLID 100 EA + E +K +K V + ++ R +K + + I D Sbjct: 91 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 150 Query: 101 TVKDPVSKTPALV-------------FEY----INNTDFKQL-------YQILTDFDIRF 136 VKDP K V F Y N F ++ ++ L Sbjct: 151 LVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQ 210 Query: 137 YMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASR 196 ++++ L H G++H ++P ++++D + + L + E V SR Sbjct: 211 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGG-VFLTGF---EHLVRDGARVVSSVSR 266 Query: 197 YFKGPELLVDYQMY----------DYSLDMWSLGCMLASMIFRREP 232 F+ PEL +S D W+LG ++ + P Sbjct: 267 GFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLP 312 >1TQM-A nrPDB Length = 282 Score = 45.7 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 34/157 (21%), Positives = 66/157 (42%), Gaps = 35/157 (22%) Query: 42 LVRKLGRGKYSEVFEAINITNNERVVVKI-------LKPVKKKK--------------IK 80 + + +G GK S VF + E V VK K VK+K+ + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECV-VKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSAR 152 Query: 81 REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYE 140 E + L+ L+G + K + A++ E I+ + ++ D + + E Sbjct: 153 NEFRALQKLQG-------LAVPKVYAWEGNAVLMELIDAKELYRVRVENPDEVLDMILEE 205 Query: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDW 177 + K + H +GI+H D+ +NV++ + + +ID+ Sbjct: 206 VAK---FYH-RGIVHGDLSQYNVLVSEEG--IWIIDF 236 >2W1Z-A nrPDB Length = 368 Score = 44.6 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 42/261 (16%), Positives = 78/261 (29%), Gaps = 67/261 (25%) Query: 34 WGNQDDYQLVRKLGR--------------GKYSEVFEAINITNNERV------------- 66 W N+ +++ +LG G Y EA + E + Sbjct: 41 WRNEQSFRVESELGERPRTLVRGPVLRDDGSY-ICLEATDQETGEPLEVHVPYFTERPPS 99 Query: 67 -VVKILKP-VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALV----------- 113 +K L V + ++ R +K + I ID VKDP + V Sbjct: 100 NAIKQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVLS 159 Query: 114 -----------FEYINNTDFKQ--LYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKP 160 + + ++ L +L++ G++H D + Sbjct: 160 RFFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQV 219 Query: 161 HNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE-----LLVDYQMY----D 211 N+++D + + L G + R F PE +L Q + Sbjct: 220 RNILLDQRGG-VFLT--GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMT 275 Query: 212 YSLDMWSLGCMLASMIFRREP 232 + D W+LG + + P Sbjct: 276 FPFDTWTLGLAIYWIWCADLP 296 >3DZO-A nrPDB Length = 413 Score = 44.2 bits (103), Expect = 9e-05, Method: Composition-based stats. Identities = 40/225 (17%), Positives = 75/225 (33%), Gaps = 52/225 (23%) Query: 56 EAINITNNERV--------------VVKILKP-VKKKKIKREVKILENLRGGTNIIKLID 100 EA + E +K +K V + ++ R +K + + I D Sbjct: 96 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 155 Query: 101 TVKDPVSKTPALV-------------FEY----INNTDFKQL-------YQILTDFDIRF 136 VKDP K V F Y N F ++ ++ L Sbjct: 156 LVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQ 215 Query: 137 YMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASR 196 ++++ L H G++H ++P ++++D + + L G + R Sbjct: 216 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGG-VFLT--GFEHLVRDGASAVSPIG-R 271 Query: 197 YFKGPE-----LLVDYQMY----DYSLDMWSLGCMLASMIFRREP 232 F PE +L Q + ++ D W+LG + + P Sbjct: 272 GFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLP 316 >4CZY-B nrPDB Length = 429 Score = 41.9 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 20/142 (14%), Positives = 52/142 (36%), Gaps = 26/142 (18%) Query: 55 FEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGT-----NIIKLIDTVKDPVSKT 109 ++A N N L+ ++ ++ E IL + NI+ + + Sbjct: 61 YKAQNNKNGRHFA---LRRIEGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGD 117 Query: 110 PALVFEY----INNTDFKQLY------------QILTDFDIRFYMYELLKALDYCHSKGI 153 +L+F Y ++ T + + + + + Y+ ++ AL H+ + Sbjct: 118 SSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKL 177 Query: 154 MHRDVKPHNVMIDHQQKKLRLI 175 R ++ ++ + ++RL Sbjct: 178 AARCLELSKII--WENNRIRLA 197 >5YK0-A nrPDB Length = 452 Score = 41.9 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 30/168 (17%), Positives = 60/168 (35%), Gaps = 43/168 (25%) Query: 52 SEVFEAINITNNERVVVKILKPVKKKKIKREVK-------ILENLRGGTNIIKLIDTVKD 104 +V +AI ++ V VKI P + ++ ++K +L+ L G ++ ++D + + Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 105 PVSKTPALVFEYINNTDFKQLYQILTDFDI--------RFYMYELLKAL----------- 145 E N F + Y F + + + E ++ + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTT 264 Query: 146 ---------------DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWG 178 D G+MH D P N M+ ++ +ID+G Sbjct: 265 EQRDLIGTLLAELTFDAPRRLGLMHGDAHPGNFML-LPDGRMGIIDFG 311 >6G18-v nrPDB Length = 552 Score = 39.2 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 31/71 (43%), Gaps = 4/71 (5%) Query: 107 SKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMID 166 A+V E IN Q++ + + EL+ L + G++H D N+++D Sbjct: 181 YNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA---NHGLIHGDFNEFNLILD 237 Query: 167 HQQKKLRLIDW 177 + +ID+ Sbjct: 238 ESD-HITMIDF 247 >4BVU-A nrPDB Length = 211 Score = 38.4 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 25/159 (15%), Positives = 60/159 (37%), Gaps = 12/159 (7%) Query: 22 REYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK- 80 + + +E + G + L + +G+G +E+FE +N ++ ++ + ++ Sbjct: 24 QTPFPFENNNSHAGIVTEPILGKLIGQGSTAEIFEDVNDSSALYKKYDLIGNQYNEILEM 83 Query: 81 --REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYM 138 +E ++ G +V L + T + +I Sbjct: 84 AWQESELFNAFYGDE------ASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLY 137 Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDW 177 +L+ L+ I+H D+ N++ D + + L ID+ Sbjct: 138 LQLICKLNEL---SIIHYDLNTGNMLYDKESESLFPIDF 173 >6FDN-A nrPDB Length = 320 Score = 38.4 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 31/71 (43%), Gaps = 4/71 (5%) Query: 107 SKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMID 166 A+V E IN Q++ + + EL+ L + G++H D N+++D Sbjct: 181 YNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA---NHGLIHGDFNEFNLILD 237 Query: 167 HQQKKLRLIDW 177 + +ID+ Sbjct: 238 ESD-HITMIDF 247 >6FAI-l nrPDB Length = 425 Score = 38.0 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 32/172 (18%), Positives = 62/172 (36%), Gaps = 31/172 (18%) Query: 33 SWGNQDD-YQLVRKLGRGKYSEVFEAINITNNERVVVKI--LKPVKKKKIKREVKILENL 89 + N+D Y + +G GK S++++ + N RV +KI L ++ L+ Sbjct: 87 TMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKS 145 Query: 90 RGGTNIIKL-------------------IDTVKDPVSKTPALVFEYINNTDFKQLYQILT 130 G N + L + + +V E I ++L + Sbjct: 146 NQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRK--- 202 Query: 131 DFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMI-----DHQQKKLRLIDW 177 +I +L+ + + G++H D N+MI D +ID+ Sbjct: 203 HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >5I35-A nrPDB Length = 393 Score = 38.0 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 35/195 (17%), Positives = 58/195 (29%), Gaps = 43/195 (22%) Query: 32 PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRG 91 P+W ++ +Y R +V A + V +KI P + I +V L + Sbjct: 68 PNWRDKLEYFEERPFAAASIGQVHLAR-MKGGREVAMKIQYPGVAQSINSDVNNLMAVLN 126 Query: 92 GTNII-------KLIDTVK-------------------------DPVSKTPALVFEYINN 119 +N++ LID ++ P P +V E + Sbjct: 127 MSNMLPEGLFPEHLIDVLRRELALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSP 186 Query: 120 TDFK-QLYQILTDFDIRFYMYELLKALDY---------CHSKGIMHRDVKPHNVMIDHQQ 169 +L E+ + Y M D N D QQ Sbjct: 187 HVLTTELVSGFPLDQAEGLSQEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQ 246 Query: 170 KKLRLIDWGLAEFYH 184 K+ L+D+G Y Sbjct: 247 HKVALLDFGATREYD 261 >4BWP-A nrPDB Length = 448 Score = 35.7 bits (81), Expect = 0.034, Method: Composition-based stats. Identities = 19/166 (11%), Positives = 52/166 (31%), Gaps = 48/166 (28%) Query: 55 FEAINITNNERVVVKILKPVKKKKIKRE-----VKILENLRGGTNIIKLIDTVKDP--VS 107 + A + T + L+ + +++ V++ + L+ N+++L + Sbjct: 67 YRATHNTTGYKY---CLRRIHGFRLQSTKCMTLVEMWKKLQHT-NVVQLREVFTTKAFGD 122 Query: 108 KTPALVFEYINN--TDFKQLYQI--------------------------------LTDFD 133 + LV++Y T + + L + Sbjct: 123 NSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEAT 182 Query: 134 IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ---KKLRLID 176 I + +L L H G+ + + P +++ ++ + D Sbjct: 183 IWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >6EF6-A nrPDB Length = 354 Score = 32.2 bits (72), Expect = 0.35, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 19/28 (67%), Gaps = 2/28 (7%) Query: 152 GIMHRDVKPHNVMIDHQ--QKKLRLIDW 177 G++H D++ N+++D Q+ + +ID+ Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >4W91-A nrPDB Length = 422 Score = 31.5 bits (70), Expect = 0.52, Method: Composition-based stats. Identities = 29/179 (16%), Positives = 65/179 (36%), Gaps = 47/179 (26%) Query: 82 EVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT------DFKQLYQILTDFDIR 135 E+ +L + +NI+ + +K LVF +++ +F++ T Sbjct: 131 EI-LLSIMEHHSNIVPWHFIRERQGAK---LVFTPVDDNGVFHIEEFEKRLSERTKLVAI 186 Query: 136 FYMYELL-------KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE 188 +M L K ++ H++GI P V++D Q + L Sbjct: 187 THMSNTLGTVVPIKKIVELAHARGI------P--VLVDGSQGAVHL------------PV 226 Query: 189 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCML--ASMIFRREPFFHGQDNYDQLVR 245 + ++ + +++Y S +G + A M+ + PF G + +++ Sbjct: 227 DVQDLGCDWY----VFTGHKVYGPS----GIGVLYGRAQMLEKMRPFQGGGEMIEEVTE 277 >5M3Y-A nrPDB Length = 458 Score = 31.5 bits (70), Expect = 0.58, Method: Composition-based stats. Identities = 26/140 (18%), Positives = 45/140 (32%), Gaps = 22/140 (15%) Query: 226 MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD-PHFNDILGQHSRKRWEN 284 M+ F H D DQ + +V TE L + H D + Q + W Sbjct: 279 MLSGMGTFQHWSDIQDQFS-VTQVPFTESASLLLIQPHYASDLDKVEGLTFQQNSLNWMK 337 Query: 285 FIHSENRHLVSPEAL--------DLLDKL-----------LRYDHQQRLTAKEAMEHPYF 325 + HL P+ + DLL + L+ R+ E + +F Sbjct: 338 KLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFF 397 Query: 326 YPVVKEQSQPCADNAVLSSG 345 + ++ +P L+ Sbjct: 398 E-LEADEREPTESTQQLNKP 416 >1WP5-A nrPDB Length = 323 Score = 31.1 bits (69), Expect = 0.79, Method: Composition-based stats. Identities = 20/76 (26%), Positives = 31/76 (40%), Gaps = 12/76 (15%) Query: 64 ERVVVKILKPVKKK---KIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 120 +R VK +K + + + KR V IL L+ + ++ V S T L E Sbjct: 214 QRGAVKKMKLTEFEKATRAKRGVVILRELKANPH--RISGFVVAQDSDTIYLQTE----- 266 Query: 121 DFKQLYQILTDFDIRF 136 K + + DIRF Sbjct: 267 --KSFIETIKVGDIRF 280 >4H05-A nrPDB Length = 273 Score = 30.7 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 10/27 (37%), Positives = 17/27 (62%), Gaps = 1/27 (3%) Query: 153 IMHRDVKPHNVMIDHQQKKLR-LIDWG 178 + H D+ P NV++D + ++ LID G Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVG 212 >5IOL-A nrPDB Length = 150 Score = 30.3 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 14/83 (16%), Positives = 35/83 (42%), Gaps = 8/83 (9%) Query: 35 GNQDDYQLVRKLG--RGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGG 92 G + + +V+ G RG EV + + V +K++ ++ ++ + L++L Sbjct: 1 GPERTFIMVKPDGVQRGLVGEVIQRFERRGYKLVAIKMM-HASEQLLQTHYEALKSLSFF 59 Query: 93 TNIIKLIDTVKDPVSKTPALVFE 115 ++ + + +VFE Sbjct: 60 PKLVAYMSS-----GPVVPMVFE 77 >1VJ7-A nrPDB Length = 393 Score = 30.3 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 16/67 (23%), Positives = 34/67 (50%), Gaps = 8/67 (11%) Query: 68 VKILKPVKKKKIKRE-VKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY 126 +K L+ K+++I RE ++I L I ++ ++D L F Y+N T+F ++ Sbjct: 152 LKHLRKDKQERISRETMEIYAPLAHRLGISRIKWELED-------LAFRYLNETEFYKIS 204 Query: 127 QILTDFD 133 ++ + Sbjct: 205 HMMNEKR 211 >6DFL-A nrPDB Length = 259 Score = 29.9 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 30/196 (15%), Positives = 63/196 (32%), Gaps = 38/196 (19%) Query: 34 WGNQDDYQLVRKLGRGKYSEVF---EAINI----TNNERVVVKILKPVKKKKI------- 79 W +D ++ V L +V+ E + VKI + + +I Sbjct: 13 WNGRDPFEAVEAL----QGKVYRELEGRRTLRTEVDGRGYFVKIHRGIGWGEIAKNLLTA 68 Query: 80 -------KREVKILENLRGGTNI-----IKLIDTVKDPVSKTPALVFEYINNT-DFKQLY 126 ++E + + L + + + DP + +V E + T D + Sbjct: 69 KLPVLGARQEWQAIRRL-HEAGVATMTAVAYGERGSDPARQHSFIVTEELAPTVDLEVFS 127 Query: 127 Q-----ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE 181 Q R + + + + H G+ HRD + ++ H K + D+ L+ Sbjct: 128 QDWRERPPPPRLKRALVEAVARMVGDMHRAGVNHRDCYICHFLL-HTDKPVSADDFRLSV 186 Query: 182 FYHPAQEYNVRVASRY 197 + R+ Sbjct: 187 IDLHRAQTRDATPKRW 202 >5YSW-A nrPDB Length = 441 Score = 29.9 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 15/105 (14%), Positives = 32/105 (30%), Gaps = 9/105 (8%) Query: 247 AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS--PEALDLLDK 304 + L + ++++ P + + + LVS EA +L Sbjct: 33 TESLRSPLPPEFVRREDPFHVPPALVAVSERGPVARATLAAGDPFWLVSGYEEARAVLS- 91 Query: 305 LLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAA 349 D R ++ HP+F + E + D+ + Sbjct: 92 ----DP--RFSSDRFQYHPWFKELSPEFRERLRDDKARAGSFINM 130 >4ESA-B nrPDB Length = 146 Score = 29.5 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 12/55 (21%), Positives = 25/55 (45%), Gaps = 11/55 (20%) Query: 49 GKYSEVFEAINITNNERVV---VKILKPVKK--------KKIKREVKILENLRGG 92 G + ++ A I N++V +K+L + + K+I E+ IL + + Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILHSEKLH 97 >1NR3-A nrPDB Length = 122 Score = 29.5 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 19/112 (16%), Positives = 43/112 (38%), Gaps = 14/112 (12%) Query: 57 AINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEY 116 +++ + + LK ++ E K +EN+ N + + ++K PV Sbjct: 1 MRERGWSQKKIARELKTTRQNVSAIERKAMENIEKSRNTLDFVKSLKSPVRI-------L 53 Query: 117 INNTD-FKQLYQILTDFDIRFYMYELLKA--LDYC----HSKGIMHRDVKPH 161 D ++ + L + + ++ + + L + S I+HR VK Sbjct: 54 CRRGDTLDEIIKRLLEESNKEGIHVIHDSITLAFLIREKASHRIVHRVVKSD 105 >2Y0O-A nrPDB Length = 175 Score = 28.8 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 11/47 (23%), Positives = 24/47 (51%) Query: 159 KPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV 205 K V+ D + +++L+D+GL + + V V + + EL++ Sbjct: 14 KAGIVLTDEEVDQIQLMDYGLGKERKVGLQLFVYVNTDRYCSKELVL 60 >2GB3-A nrPDB Length = 409 Score = 28.4 bits (62), Expect = 4.6, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 16/32 (50%), Gaps = 2/32 (6%) Query: 157 DVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE 188 DVKP NV++ + + L + A +P E Sbjct: 99 DVKPENVLVTNGGSEAIL--FSFAVIANPGDE 128 >5H12-A nrPDB Length = 775 Score = 28.4 bits (62), Expect = 4.6, Method: Composition-based stats. Identities = 13/32 (40%), Positives = 18/32 (56%) Query: 52 SEVFEAINITNNERVVVKILKPVKKKKIKREV 83 ++V EAI N VKI+K V +K K E+ Sbjct: 625 AKVLEAILKHGNVEEAVKIVKEVTEKLSKYEI 656 >4GYG-A nrPDB Length = 397 Score = 28.4 bits (62), Expect = 4.9, Method: Composition-based stats. Identities = 24/170 (14%), Positives = 56/170 (32%), Gaps = 21/170 (12%) Query: 5 AAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEV-----FEAIN 59 +R VY+ + + + D G Q ++ R LGR + V + N Sbjct: 89 THAARKDVYSVGSRIGVGKESDIMIVADEKGKQKVLKIHR-LGRISFRTVKANRDYL-RN 146 Query: 60 ITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINN 119 + + + + +E ++ L + + +V + Sbjct: 147 RSTGSWMYL------SRLAAIKEFAFMKALYEEGFPVP-----EPIAQSRHTIVMSLV-- 193 Query: 120 TDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQ 169 D + Q+ + D +L+ + G++H D N++I ++ Sbjct: 194 -DALPMRQVSSVPDPASLYADLIALILRLAKHGLIHGDFNEFNILIREEK 242 >5KKY-A nrPDB Length = 496 Score = 28.4 bits (62), Expect = 5.1, Method: Composition-based stats. Identities = 14/62 (22%), Positives = 25/62 (40%), Gaps = 4/62 (6%) Query: 5 AAGSRARVYAEVNSLRSREYWDYEA--HVPSWGNQDDYQLVRKLGRGKYSEVFEAINITN 62 AG R V+ R E + H P + Y +++LG G+Y ++E + Sbjct: 419 NAGGPKRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYE--HTEK 476 Query: 63 NE 64 + Sbjct: 477 GQ 478 >1YE8-A nrPDB Length = 178 Score = 28.0 bits (61), Expect = 5.9, Method: Composition-based stats. Identities = 17/128 (13%), Positives = 38/128 (29%), Gaps = 39/128 (30%) Query: 2 PGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGR------------- 48 PG + + E R+ +W E P + ++++ G+ Sbjct: 9 PGVGKTTLVKKIVERLGKRAIGFWTEEVRDPETKKRTGFRIITTEGKKKIFSSKFFTSKK 68 Query: 49 --GKYSEVFEAINITNNERVVVKILKPVKKKK--------IKREV-----------KILE 87 G Y N+ E + + IL+ ++ I E+ ++ Sbjct: 69 LVGSYGV-----NVQYFEELAIPILERAYREAKKDRRKVIIIDEIGKMELFSKKFRDLVR 123 Query: 88 NLRGGTNI 95 + N+ Sbjct: 124 QIMHDPNV 131 >4FLV-A nrPDB Length = 793 Score = 28.0 bits (61), Expect = 6.8, Method: Composition-based stats. Identities = 13/32 (40%), Positives = 18/32 (56%) Query: 52 SEVFEAINITNNERVVVKILKPVKKKKIKREV 83 ++V EAI N VKI+K V +K K E+ Sbjct: 646 AKVLEAILKHGNVDEAVKIVKEVTEKLSKYEI 677 >6HXI-B nrPDB Length = 631 Score = 28.0 bits (61), Expect = 7.2, Method: Composition-based stats. Identities = 17/78 (21%), Positives = 28/78 (35%), Gaps = 1/78 (1%) Query: 228 FRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIH 287 E + G+ D L R + G L + KK + HF +++ Q Sbjct: 363 SGEELLYAGKKLSDVLDRKMGIGGVIGLL-WFKKELPEYAAHFIELVIQIVADHGPAVSG 421 Query: 288 SENRHLVSPEALDLLDKL 305 + N + S DL+ L Sbjct: 422 AHNAIVASCAGKDLISSL 439 >2P8J-A nrPDB Length = 209 Score = 27.6 bits (60), Expect = 7.6, Method: Composition-based stats. Identities = 10/60 (16%), Positives = 25/60 (41%), Gaps = 9/60 (15%) Query: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIK 97 + Y K+G G++ + + E+V I V ++ + K ++ L +++ Sbjct: 134 ERYNKGEKIGEGEF------LQLERGEKV---IHSYVSLEEADKYFKDMKVLFKEDRVVE 184 >4K8X-A nrPDB Length = 775 Score = 27.6 bits (60), Expect = 8.2, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 29/65 (44%), Gaps = 5/65 (7%) Query: 54 VFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALV 113 V + + V VK + V+KK + R +++ + + ++D + PA+V Sbjct: 51 VKKVTAKRHGTVVKVKRAEKVQKKFLGRPIEVWKLYFNHPQDVP---AIRDRIRAHPAVV 107 Query: 114 --FEY 116 +EY Sbjct: 108 DIYEY 112 >3J9M-AD nrPDB Length = 430 Score = 27.2 bits (59), Expect = 9.6, Method: Composition-based stats. Identities = 9/51 (17%), Positives = 26/51 (50%), Gaps = 1/51 (1%) Query: 39 DYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-KPVKKKKIKREVKILEN 88 D + +G G+Y ++ +N+ + V+ + + K+++ K E +++ Sbjct: 125 DLNRGQIIGEGRYGFLWPGLNVPLMKNGAVQTIAQRSKEEQEKVEADMIQQ 175 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.145 0.448 Lambda K H 0.267 0.0442 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,411,431 Number of Sequences: 36641 Number of extensions: 691562 Number of successful extensions: 6304 Number of sequences better than 10.0: 520 Number of HSP's better than 10.0 without gapping: 814 Number of HSP's successfully gapped in prelim test: 150 Number of HSP's that attempted gapping in prelim test: 2048 Number of HSP's gapped (non-prelim): 1342 length of query: 350 length of database: 10,336,785 effective HSP length: 98 effective length of query: 252 effective length of database: 6,745,967 effective search space: 1699983684 effective search space used: 1699983684 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 60 (27.6 bits)