BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P19367 (917 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4FOI-A nrPDB 1892 0.0 1BG3-A nrPDB 1763 0.0 5HFU-A nrPDB 1418 0.0 3HM8-A nrPDB 594 e-170 3W0L-A nrPDB 512 e-145 4DCH-A nrPDB 511 e-145 1BDG-A nrPDB 379 e-105 5ZQT-A nrPDB 270 2e-72 3O1W-A nrPDB 268 6e-72 1IG8-A nrPDB 252 6e-67 4QS9-A nrPDB 246 3e-65 3B8A-X nrPDB 243 2e-64 2YHX-A nrPDB 42 0.001 1HKG-A nrPDB 40 0.004 4OCK-A nrPDB 32 1.1 4FDG-B nrPDB 31 2.1 3F9V-A nrPDB 31 2.3 2WCZ-A nrPDB 31 2.3 4R7Y-A nrPDB 31 2.5 5MB9-A nrPDB 30 4.6 2JXP-A nrPDB 30 5.3 >4FOI-A nrPDB Length = 917 Score = 1892 bits (4901), Expect = 0.0, Method: Compositional matrix adjust. Identities = 916/917 (99%), Positives = 917/917 (100%) Query: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT Sbjct: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60 Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH Sbjct: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120 Query: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV Sbjct: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180 Query: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240 Query: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300 Query: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG Sbjct: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360 Query: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 420 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGV+GSLYKTH Sbjct: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVNGSLYKTH 420 Query: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480 Query: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV Sbjct: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540 Query: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF Sbjct: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600 Query: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG Sbjct: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660 Query: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD Sbjct: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720 Query: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG Sbjct: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780 Query: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840 Query: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG Sbjct: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900 Query: 901 AALITAVGVRLRTEASS 917 AALITAVGVRLRTEASS Sbjct: 901 AALITAVGVRLRTEASS 917 >1BG3-A nrPDB Length = 918 Score = 1763 bits (4566), Expect = 0.0, Method: Compositional matrix adjust. Identities = 850/916 (92%), Positives = 892/916 (97%) Query: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDE LIDI+TRF+KEMKNGLSRD+NPTA+ Sbjct: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTAS 60 Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNV MESE+YDTPENIVH Sbjct: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH 120 Query: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180 GSG+QLFDHVA+CLGDFMEK+KIKDKKLPVGFTFSFPC+QSKIDEA+LITWTKRFKASGV Sbjct: 121 GSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGV 180 Query: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQ CEVGLIIGTGTNACYME Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYME 240 Query: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRE+DRGSLNPGKQLFEKMVSGM Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGM 300 Query: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360 Y+GELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEK+KEG+ NAKEILTRLG Sbjct: 301 YMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLG 360 Query: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 420 VEPSD DCVSVQH+CTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYK H Sbjct: 361 VEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMH 420 Query: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480 PQYSRRFHKTLRRLVPDSDVRFLLSESG+GKGAAMVTAVAYRLAEQHRQIEETLAHF L+ Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS 480 Query: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540 K L+EVKKR+R EME+GLRK+T++ A VKMLPSFVR PDGTE+GDFLALDLGGTNFRV Sbjct: 481 KQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRV 540 Query: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600 LLVKIRSGKKRTVEMHNKIY+IP+EIMQGTG+ELFDHIVSCISDFLDYMGIKGPRMPLGF Sbjct: 541 LLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGF 600 Query: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660 TFSFPC QT+LD GILI+WTKGFKATDC GHDV +LLRDA+KRREEFDLDVVAVVNDTVG Sbjct: 601 TFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVG 660 Query: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720 TMMTCAYEEPTCE+GLIVGTG+NACYMEEMKNVEMVEG+QGQMCINMEWGAFGDNGCLDD Sbjct: 661 TMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDD 720 Query: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780 IRT +D++VDEYSLN+GKQR+EKMISGMYLGEIVRNILIDFTKKGFLFRGQISE LKTRG Sbjct: 721 IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG 780 Query: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVS+RAAQLCGAGMAA Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA 840 Query: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900 VV+KIRENRGLD LNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKC VSFLLSEDGSGKG Sbjct: 841 VVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKG 900 Query: 901 AALITAVGVRLRTEAS 916 AALITAVGVRLR + S Sbjct: 901 AALITAVGVRLRGDPS 916 >5HFU-A nrPDB Length = 923 Score = 1418 bits (3670), Expect = 0.0, Method: Compositional matrix adjust. Identities = 662/896 (73%), Positives = 780/896 (87%) Query: 17 DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76 DQV+K+D+YLY MRLSDETL++I RFRKEM+ GL +PTA VKMLPTFVRS PDG+E Sbjct: 23 DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 82 Query: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGD 136 G+F+ALDLGG++FR+L V+V Q V ME+++Y PE+I+ GSG+QLFDH+AECL + Sbjct: 83 HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 142 Query: 137 FMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKR 196 FM+K +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGVEG DVV L+ KAI++R Sbjct: 143 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 202 Query: 197 GDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256 GD+D +IVAVVNDTVGTMMTCGYDD +CE+GLI+GTG+NACYMEE+RHID+VEGDEGRMC Sbjct: 203 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC 262 Query: 257 INTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKE 316 IN EWGAFGDDGSL DIRTEFD+EID GSLNPGKQLFEKM+SGMY+GELVRLILVKMAKE Sbjct: 263 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 322 Query: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCT 376 LLF G+++PELL G+F T D+S IE K+G+ A+E+L RLG++P+ +DCV+ +C Sbjct: 323 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ 382 Query: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVP 436 IVS RSA+L AATL A+L R+++NKG RLR+T+GVDGS+YK HP +++R HKT+RRLVP Sbjct: 383 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP 442 Query: 437 DSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEME 496 DVRFL SE GSGKGAAMVTAVAYRLA+QHR ++TL H L+ D LLEVK+RM+ EME Sbjct: 443 GCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEME 502 Query: 497 LGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMH 556 GL K+TH +A VKMLP++V TPDGTE GDFLALDLGGTNFRVLLV++R+GK VEMH Sbjct: 503 RGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMH 562 Query: 557 NKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGIL 616 NKIYAIP E+M GTG+ELFDHIV CI+DFL+YMG+KG +PLGFTFSFPCQQ SLD IL Sbjct: 563 NKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESIL 622 Query: 617 ITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGL 676 + WTKGFKA+ C G DVVTLL++AI RREEFDLDVVAVVNDTVGTMMTC +E+P CEVGL Sbjct: 623 LKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGL 682 Query: 677 IVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNA 736 IVGTGSNACYMEEM+NVE+VEG++G+MC+NMEWGAFGDNGCLDD RT +D VDE SLN Sbjct: 683 IVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNP 742 Query: 737 GKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLA 796 GKQR+EKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRGIFETKFLSQIESD LA Sbjct: 743 GKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLA 802 Query: 797 LLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNV 856 LLQVRAILQ LGL STCDDSI+VK VC VV+RRAAQLCGAGMAAVVD+IRENRGLD L V Sbjct: 803 LLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKV 862 Query: 857 TVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLR 912 TVGVDGTLYKLHPHF+++MH+TVK+L+PKC+VSFL SEDGSGKGAALITAV R+R Sbjct: 863 TVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIR 918 Score = 558 bits (1437), Expect = e-159, Method: Compositional matrix adjust. Identities = 258/451 (57%), Positives = 347/451 (76%) Query: 461 YRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTP 520 ++ ++Q +++++ L H L+ + LLE+ KR R EME GL TH A VKMLP+FVR TP Sbjct: 19 FQGSDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTP 78 Query: 521 DGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVS 580 DGTE+G+FLALDLGGTNFRVL VK+ + VEM N+IYAIP +IM+G+G +LFDHI Sbjct: 79 DGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAE 138 Query: 581 CISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDA 640 C+++F+D + IK ++PLGFTFSFPC QT LD L++WTKGFK++ G DVV L+R A Sbjct: 139 CLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKA 198 Query: 641 IKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQ 700 I+RR +FD+D+VAVVNDTVGTMMTC Y++ CE+GLIVGTGSNACYMEEM++++MVEGD+ Sbjct: 199 IQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDE 258 Query: 701 GQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILID 760 G+MCINMEWGAFGD+G L+DIRT +D+ +D SLN GKQ +EKMISGMY+GE+VR IL+ Sbjct: 259 GRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVK 318 Query: 761 FTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVK 820 K+ LF G++S L G FETK +S IE ++ + + R +L +LGL+ T +D + Sbjct: 319 MAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATH 378 Query: 821 TVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVK 880 +C +VS R+A LC A +AAV+ +I+EN+G +RL T+GVDG++YK HPHF++ +H+TV+ Sbjct: 379 RICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVR 438 Query: 881 ELSPKCNVSFLLSEDGSGKGAALITAVGVRL 911 L P C+V FL SEDGSGKGAA++TAV RL Sbjct: 439 RLVPGCDVRFLRSEDGSGKGAAMVTAVAYRL 469 Score = 535 bits (1377), Expect = e-152, Method: Compositional matrix adjust. Identities = 248/449 (55%), Positives = 339/449 (75%) Query: 17 DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76 DQ + K L ++LS + L+++ R + EM+ GLS++ + +A VKMLPT+V + PDG+E Sbjct: 471 DQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTE 530 Query: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGD 136 KGDF+ALDLGG++FR+L V+V + K V M +++Y P+ ++HG+G +LFDH+ +C+ D Sbjct: 531 KGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIAD 590 Query: 137 FMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKR 196 F+E +K LP+GFTFSFPCQQ+ +DE+IL+ WTK FKASG EG DVV LL +AI +R Sbjct: 591 FLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRR 650 Query: 197 GDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256 ++D ++VAVVNDTVGTMMTCG++D HCEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC Sbjct: 651 EEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMC 710 Query: 257 INTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKE 316 +N EWGAFGD+G L+D RTEFD +D SLNPGKQ FEKM+SGMYLGE+VR IL+ K Sbjct: 711 VNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKR 770 Query: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCT 376 GLLF GRI+ L TRG F T +S IE + L + IL LG+E + DD + V+ VCT Sbjct: 771 GLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCT 830 Query: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVP 436 +V+ R+A L A + A+++R+R+N+G L+ TVGVDG+LYK HP +++ H+T++ L P Sbjct: 831 VVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAP 890 Query: 437 DSDVRFLLSESGSGKGAAMVTAVAYRLAE 465 DV FL SE GSGKGAA++TAVA R+ E Sbjct: 891 KCDVSFLQSEDGSGKGAALITAVACRIRE 919 >3HM8-A nrPDB Length = 445 Score = 594 bits (1531), Expect = e-170, Method: Compositional matrix adjust. Identities = 285/445 (64%), Positives = 352/445 (79%), Gaps = 7/445 (1%) Query: 467 HRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENG 526 R +EETLA F L D L V+ +MR M GLR + + ++MLP+FVR TPDG+E G Sbjct: 3 RRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASS---LRMLPTFVRATPDGSERG 59 Query: 527 DFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFL 586 DFLALDLGGTNFRVLLV++ +G V++ ++IY+IP + QG+G++LFDHIV CI DF Sbjct: 60 DFLALDLGGTNFRVLLVRVTTG----VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQ 115 Query: 587 DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREE 646 G+ G +PLGFTFSFPC+Q LD GIL+ WTKGFKA+DC G DVV+LLR+AI RR+ Sbjct: 116 QKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQA 175 Query: 647 FDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCIN 706 +L+VVA+VNDTVGTMM+C YE+P CE+GLIVGTG+NACYMEE++NV V GD G+MCIN Sbjct: 176 VELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCIN 235 Query: 707 MEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGF 766 MEWGAFGD+G L + T +D VD+ S+N GKQR+EKMISGMYLGEIVR+IL+ T G Sbjct: 236 MEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGV 295 Query: 767 LFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVV 826 LFRGQ + L+TR IF+TKFLS+IESD LAL QVRAIL+ LGL T DD+++V VC V Sbjct: 296 LFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAV 355 Query: 827 SRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKC 886 S+RAAQLCGAG+AAVV+KIRENRGL+ L V+VGVDGTLYKLHP FS ++ TV+EL+P+C Sbjct: 356 SQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRC 415 Query: 887 NVSFLLSEDGSGKGAALITAVGVRL 911 V+FL SEDGSGKGAAL+TAV RL Sbjct: 416 VVTFLQSEDGSGKGAALVTAVACRL 440 Score = 481 bits (1237), Expect = e-136, Method: Compositional matrix adjust. Identities = 232/449 (51%), Positives = 309/449 (68%), Gaps = 7/449 (1%) Query: 20 KKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGD 79 + +++ L RL+ + L + + RK M GL + ++++MLPTFVR+ PDGSE+GD Sbjct: 4 RLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGE---ASSLRMLPTFVRATPDGSERGD 60 Query: 80 FIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 139 F+ALDLGG++FR+L V+V V + SE+Y PE + GSG QLFDH+ +C+ DF + Sbjct: 61 FLALDLGGTNFRVLLVRVTT----GVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQ 116 Query: 140 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 199 K+ + + LP+GFTFSFPC+Q +D+ IL+ WTK FKAS EG DVV LL +AI +R Sbjct: 117 KQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAV 176 Query: 200 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 259 + N+VA+VNDTVGTMM+CGY+D CE+GLI+GTGTNACYMEELR++ V GD GRMCIN Sbjct: 177 ELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINM 236 Query: 260 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 319 EWGAFGDDGSL + T FD +D+ S+NPGKQ FEKM+SGMYLGE+VR IL+ + G+L Sbjct: 237 EWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVL 296 Query: 320 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 379 F G+ L TR F T +S IE + L + IL LG+ + DD + V VC VS Sbjct: 297 FRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVS 356 Query: 380 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 439 R+A L A + A++ ++R+N+G L +VGVDG+LYK HP++S T+R L P Sbjct: 357 QRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCV 416 Query: 440 VRFLLSESGSGKGAAMVTAVAYRLAEQHR 468 V FL SE GSGKGAA+VTAVA RLA+ R Sbjct: 417 VTFLQSEDGSGKGAALVTAVACRLAQLTR 445 >3W0L-A nrPDB Length = 458 Score = 512 bits (1319), Expect = e-145, Method: Compositional matrix adjust. Identities = 246/447 (55%), Positives = 329/447 (73%), Gaps = 2/447 (0%) Query: 467 HRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENG 526 ++++ L+ FHL ++ L + RM+AEME GL +T+ A VKMLP++VR TPDG+E G Sbjct: 6 QNEVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVG 65 Query: 527 DFLALDLGGTNFRVLLVKIRSG--KKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 584 DFLALDLGGTNFRV+LVK+ + VE +K+Y+IP++ M GT E LFD+I CISD Sbjct: 66 DFLALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIAECISD 125 Query: 585 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 644 +LD +K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAIKRR Sbjct: 126 YLDQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRR 185 Query: 645 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 704 +F++DVVA+VNDTV TM++C YE+ CEVGLIVGTG NACYMEEM NVE+VEG++G+MC Sbjct: 186 GDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGEEGRMC 245 Query: 705 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 764 +N EWGAFGD G L+D R YDR+VDE SLN G+Q YEKMI G Y+GE+VR +LI + Sbjct: 246 VNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNE 305 Query: 765 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 824 LF G+ SE LKTRG FET+F+SQIE+D Q IL+ LG+ +T D V+ C Sbjct: 306 NLLFGGESSEKLKTRGAFETQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAVRLACE 365 Query: 825 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 884 VS RAA +C AG+A +++++R++R + L +TVGVDG++YKLHP F H TV +L+ Sbjct: 366 SVSTRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATVLKLTS 425 Query: 885 KCNVSFLLSEDGSGKGAALITAVGVRL 911 C ++F+ SE+GSG+GAALI+AV ++ Sbjct: 426 GCEITFIQSEEGSGRGAALISAVAYKM 452 Score = 493 bits (1269), Expect = e-139, Method: Compositional matrix adjust. Identities = 231/446 (51%), Positives = 318/446 (71%), Gaps = 2/446 (0%) Query: 21 KIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 80 ++D+ L L +E L +M R + EM+ GL + N A+VKMLPT+VRS PDGSE GDF Sbjct: 8 EVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVGDF 67 Query: 81 IALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM 138 +ALDLGG++FR++ V+V E V + ++Y P + + G+ LFD++AEC+ D++ Sbjct: 68 LALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIAECISDYL 127 Query: 139 EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD 198 +++ +K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RGD Sbjct: 128 DQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGD 187 Query: 199 YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 258 ++ ++VA+VNDTV TM++C Y+D HCEVGLI+GTG NACYMEE+ +++LVEG+EGRMC+N Sbjct: 188 FEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGEEGRMCVN 247 Query: 259 TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL 318 TEWGAFGD G LED R E+DR +D SLNPG+QL+EKM+ G Y+GELVRL+L+KM E L Sbjct: 248 TEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNENL 307 Query: 319 LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV 378 LF G + +L TRG F T VS IE + IL LGV+ + DC +V+ C V Sbjct: 308 LFGGESSEKLKTRGAFETQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAVRLACESV 367 Query: 379 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS 438 S R+A + +A L ILNR+R ++ LR TVGVDGS+YK HP + +FH T+ +L Sbjct: 368 STRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATVLKLTSGC 427 Query: 439 DVRFLLSESGSGKGAAMVTAVAYRLA 464 ++ F+ SE GSG+GAA+++AVAY++A Sbjct: 428 EITFIQSEEGSGRGAALISAVAYKMA 453 >4DCH-A nrPDB Length = 473 Score = 511 bits (1315), Expect = e-145, Method: Compositional matrix adjust. Identities = 244/449 (54%), Positives = 334/449 (74%), Gaps = 2/449 (0%) Query: 464 AEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGT 523 A + ++E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+ Sbjct: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69 Query: 524 ENGDFLALDLGGTNFRVLLVKIRSGK--KRTVEMHNKIYAIPIEIMQGTGEELFDHIVSC 581 E GDFL+LDLGGTNFRV+LVK+ G+ + +V+ +++Y+IP + M GT E LFD+I C Sbjct: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129 Query: 582 ISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAI 641 ISDFLD +K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAI Sbjct: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189 Query: 642 KRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQG 701 KRR +F++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G Sbjct: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249 Query: 702 QMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDF 761 +MC+N EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+ Sbjct: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309 Query: 762 TKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKT 821 + LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+ Sbjct: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369 Query: 822 VCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKE 881 C VS RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+ Sbjct: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429 Query: 882 LSPKCNVSFLLSEDGSGKGAALITAVGVR 910 L+P C ++F+ SE+GSG+GAAL++AV + Sbjct: 430 LTPSCEITFIESEEGSGRGAALVSAVACK 458 Score = 473 bits (1217), Expect = e-133, Method: Compositional matrix adjust. Identities = 225/454 (49%), Positives = 325/454 (71%), Gaps = 2/454 (0%) Query: 20 KKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGD 79 +K+++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE GD Sbjct: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73 Query: 80 FIALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDF 137 F++LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ DF Sbjct: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133 Query: 138 MEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRG 197 ++K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RG Sbjct: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193 Query: 198 DYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCI 257 D++ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+ Sbjct: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 253 Query: 258 NTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEG 317 NTEWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ E Sbjct: 254 NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 313 Query: 318 LLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTI 377 LLF G + +L TRG F T VS +E + IL+ LG+ PS DC V+ C Sbjct: 314 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 373 Query: 378 VSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPD 437 VS R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RFH ++RRL P Sbjct: 374 VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPS 433 Query: 438 SDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIE 471 ++ F+ SE GSG+GAA+V+AVA + A Q+E Sbjct: 434 CEITFIESEEGSGRGAALVSAVACKKACMLGQLE 467 >1BDG-A nrPDB Length = 451 Score = 379 bits (973), Expect = e-105, Method: Compositional matrix adjust. Identities = 207/448 (46%), Positives = 282/448 (62%), Gaps = 15/448 (3%) Query: 469 QIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDF 528 ++ E L F L+ E+ RM M LGL+K T+ + +KM PS+V +TP+GTE G+F Sbjct: 11 KVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTETGNF 70 Query: 529 LALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDY 588 LALDLGGTN+RVL V + GK ++ + + Y IP E M G+G ELF +I ++DFL+ Sbjct: 71 LALDLGGTNYRVLSVTLE-GKGKSPRIQERTYCIPAEKMSGSGTELFKYIAETLADFLEN 129 Query: 589 MGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFD 648 G+K + LGFTFSFPC Q L L+ WTKGF A GH+V LL+ + +RE + Sbjct: 130 NGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKRE-LN 188 Query: 649 LDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEG-DQGQMCINM 707 + VAVVNDTVGT+ +CA E+P C VGLIVGTG+N Y+E+ VE+++G + ++ IN Sbjct: 189 VKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVKEPEVVINT 248 Query: 708 EWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFL 767 EWGAFG+ G LD RT +D+ +D SL+ GKQ YEKM+SGMYLGE+VR+I++ ++ L Sbjct: 249 EWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLVEQKIL 308 Query: 768 FRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSI---LVKTVCG 824 FRG + E LK R T++L+ +E D LL + L+ + I +V+ C Sbjct: 309 FRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDNRIVRYACE 368 Query: 825 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 884 +V +RAA L GAG+A ++ R ++R VTVGVDG+LYK HP F M V +L P Sbjct: 369 MVVKRAAYLAGAGIACIL------RRINRSEVTVGVDGSLYKFHPKFCERMTDMVDKLKP 422 Query: 885 KCNVSFL--LSEDGSGKGAALITAVGVR 910 K N F LSEDGSGKGAA I A R Sbjct: 423 K-NTRFCLRLSEDGSGKGAAAIAASCTR 449 Score = 343 bits (881), Expect = 1e-94, Method: Compositional matrix adjust. Identities = 194/458 (42%), Positives = 279/458 (60%), Gaps = 20/458 (4%) Query: 14 LKDDQV-KKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIP 72 D Q+ +K+ + L LS +I R + M+ GL + N +++KM P++V P Sbjct: 3 FSDQQLFEKVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTP 62 Query: 73 DGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAE 132 +G+E G+F+ALDLGG+++R+L V + K ++ ++ Y P + GSG++LF ++AE Sbjct: 63 NGTETGNFLALDLGGTNYRVLSVTLEG-KGKSPRIQERTYCIPAEKMSGSGTELFKYIAE 121 Query: 133 CLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKA 192 L DF+E +KDKK +GFTFSFPC Q + A L+ WTK F A GVEG +V +LL Sbjct: 122 TLADFLENNGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTE 181 Query: 193 IKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEG-D 251 + KR + + VAVVNDTVGT+ +C +D C VGLI+GTGTN Y+E+ ++L++G Sbjct: 182 LDKR-ELNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVK 240 Query: 252 EGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILV 311 E + INTEWGAFG+ G L+ RT+FD+ +D SL+PGKQL+EKMVSGMYLGELVR I+V Sbjct: 241 EPEVVINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIV 300 Query: 312 KMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEG-LHNAKEILTR----LGVEPSDD 366 + ++ +LF G + L R T ++ +E++ L+N +LT VEP D+ Sbjct: 301 YLVEQKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDN 360 Query: 367 DCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRR 426 V++ C +V R+A L A + IL R+ R TVGVDGSLYK HP++ R Sbjct: 361 RI--VRYACEMVVKRAAYLAGAGIACILRRIN------RSEVTVGVDGSLYKFHPKFCER 412 Query: 427 FHKTLRRLVPDSDVRFL--LSESGSGKGAAMVTAVAYR 462 + +L P + RF LSE GSGKGAA + A R Sbjct: 413 MTDMVDKLKP-KNTRFCLRLSEDGSGKGAAAIAASCTR 449 >5ZQT-A nrPDB Length = 473 Score = 270 bits (691), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 177/455 (38%), Positives = 243/455 (53%), Gaps = 24/455 (5%) Query: 470 IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFL 529 IEE F +L + M EME GLR H A +KML S+V P G E+G F Sbjct: 16 IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYVDNLPTGDEHGLFY 73 Query: 530 ALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFL--- 586 ALDLGGTNFRV+ V++ +KR V + AIP +M GT ELFD I + + F+ Sbjct: 74 ALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTE 133 Query: 587 --DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 644 D+ +G + LGFTFSFP QTS+ +G LI WTKGF VG DVV L A++ R Sbjct: 134 GEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME-R 192 Query: 645 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEG---DQG 701 + D+ V A+VNDTVGT+ Y + +I+GTG+NA Y+E + G G Sbjct: 193 QGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSG 252 Query: 702 QMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDF 761 M INMEWG F R+ YD +D SLN G+Q YEKMISGMYLGEIVR IL+ Sbjct: 253 NMVINMEWGNFKSERL---PRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKL 309 Query: 762 TKKGFLFRGQISETLKTRGIFETKFLSQIESDRLA-LLQVRAILQQ-LGL-NSTCDDSIL 818 LF + L+ R I T +S + D L + A L+ LG+ +++ + + Sbjct: 310 AHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYI 369 Query: 819 VKTVCGVVSRRAAQLCGAGMAAVVDKIRENR----GLDRLNVTVGVDGTLYKLHPHFSRI 874 VC +V+ R A+L AG+ ++ K+ +R G + + +DG LY+ + F Sbjct: 370 TLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTC 429 Query: 875 MHQTVKEL---SPKCNVSFLLSEDGSGKGAALITA 906 + T+ +L +V L+ DGSG GAAL+ A Sbjct: 430 LEATLADLLGEEAASSVVVKLANDGSGIGAALLAA 464 Score = 259 bits (661), Expect = 5e-69, Method: Compositional matrix adjust. Identities = 166/435 (38%), Positives = 247/435 (56%), Gaps = 30/435 (6%) Query: 45 KEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104 +EM+ GL D P A +KML ++V ++P G E G F ALDLGG++FR++RVQ+ + + Sbjct: 39 EEMERGLRAD--PHAPLKMLISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRV 96 Query: 105 VHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLP------VGFTFSFPC 158 V + E P +++ G+ +LFD +A L F+ K + +D LP +GFTFSFP Sbjct: 97 VSQQYEEVAIPPHLMVGTSMELFDFIAAELESFV-KTEGEDFHLPEGRQRELGFTFSFPV 155 Query: 159 QQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCG 218 Q+ I LI WTK F +G G DVV L++A++++G D + A+VNDTVGT+ Sbjct: 156 HQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQG-LDMKVTALVNDTVGTLAGGR 214 Query: 219 YDDQHCEVGLIIGTGTNACYMEELRHIDLVEG---DEGRMCINTEWGAFGDDGSLEDIRT 275 Y D +I+GTGTNA Y+E I G G M IN EWG F + R+ Sbjct: 215 YVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSGNMVINMEWGNFKSE---RLPRS 271 Query: 276 EFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFN 335 ++D +D SLNPG+Q++EKM+SGMYLGE+VR IL+K+A + LF + +L R Sbjct: 272 DYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILR 331 Query: 336 TSDVSAIEKNKEGLHNAKEILTR----LGVEPSDDDCVSVQ-HVCTIVSFRSANLVAATL 390 T D+SA+ + H+ K + + LGV + + + HVC +V+ R A L AA + Sbjct: 332 TPDMSAMHHDTS--HDLKHLGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAGI 389 Query: 391 GAILNRL-RD---NKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPD---SDVRFL 443 IL +L RD + G+ + RT + +DG LY+ + ++ TL L+ + S V Sbjct: 390 YGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLEATLADLLGEEAASSVVVK 449 Query: 444 LSESGSGKGAAMVTA 458 L+ GSG GAA++ A Sbjct: 450 LANDGSGIGAALLAA 464 >3O1W-A nrPDB Length = 485 Score = 268 bits (686), Expect = 6e-72, Method: Compositional matrix adjust. Identities = 166/479 (34%), Positives = 259/479 (54%), Gaps = 33/479 (6%) Query: 448 GSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNA 507 G K A ++A A QI F ++ + + + K +E++ GL K+ N Sbjct: 5 GPKKPPARKGSMADVPANLMEQIHGLETLFTVSSEKMRSIVKHFISELDKGLSKKGGN-- 62 Query: 508 VVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIM 567 + M+P +V P G E GDFLALDLGGTN RV+LVK+ G + Y +P + Sbjct: 63 -IPMIPGWVVEYPTGKETGDFLALDLGGTNLRVVLVKL--GGNHDFDTTQNKYRLPDHLR 119 Query: 568 QGTGEELFDHIVSCISDFLDYM---GIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFK 624 GT E+L+ I C+ +F+D G+ P +PLGFTFS+P Q +++G+L WTKGF Sbjct: 120 TGTSEQLWSFIAKCLKEFVDEWYPDGVSEP-LPLGFTFSYPASQKKINSGVLQRWTKGFD 178 Query: 625 ATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNA 684 GHDVV +L++ I++ ++VVA++NDT GT++ Y +P ++G+I+GTG N Sbjct: 179 IEGVEGHDVVPMLQEQIEKLN-IPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNG 237 Query: 685 CYMEEMKNVEMVEG-------DQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAG 737 Y + + +E +EG M IN E+G+F DN L RT YD ++DE S G Sbjct: 238 AYYDVVSGIEKLEGLLPEDIGPDSPMAINCEYGSF-DNEHLVLPRTKYDVIIDEESPRPG 296 Query: 738 KQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLAL 797 +Q +EKM SG YLGEI+R +L+D GF+F+ Q LK + +T + S+IE D Sbjct: 297 QQAFEKMTSGYYLGEIMRLVLLDLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFEN 356 Query: 798 LQVRAILQQLGLN--STCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLN 855 L+ L + LN +T + L++ + +V RAA+L G++A+ DK RG + Sbjct: 357 LEDTDDLFKTNLNIETTVVERKLIRKLAELVGTRAARLTVCGVSAICDK----RGYKTAH 412 Query: 856 VTVGVDGTLYKLHPHFSRIMHQTVKELS-------PKCNVSFLLSEDGSGKGAALITAV 907 + DG+++ +P + Q +K++ + + +EDGSG GAA+I + Sbjct: 413 --IAADGSVFNRYPGYKEKAAQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIACL 469 Score = 234 bits (598), Expect = 9e-62, Method: Compositional matrix adjust. Identities = 150/453 (33%), Positives = 246/453 (54%), Gaps = 32/453 (7%) Query: 31 LSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSF 90 +S E + I+ F E+ GLS+ + M+P +V P G E GDF+ALDLGG++ Sbjct: 36 VSSEKMRSIVKHFISELDKGLSKK---GGNIPMIPGWVVEYPTGKETGDFLALDLGGTNL 92 Query: 91 RILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIK--DKKL 148 R++ V++ N + Y P+++ G+ QL+ +A+CL +F+++ + L Sbjct: 93 RVVLVKLG--GNHDFDTTQNKYRLPDHLRTGTSEQLWSFIAKCLKEFVDEWYPDGVSEPL 150 Query: 149 PVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVN 208 P+GFTFS+P Q KI+ +L WTK F GVEG DVV +L + I+K + N+VA++N Sbjct: 151 PLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVPMLQEQIEKL-NIPINVVALIN 209 Query: 209 DTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVE-------GDEGRMCINTEW 261 DT GT++ Y D ++G+IIGTG N Y + + I+ +E G + M IN E+ Sbjct: 210 DTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEKLEGLLPEDIGPDSPMAINCEY 269 Query: 262 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 321 G+F D+ L RT++D ID S PG+Q FEKM SG YLGE++RL+L+ + G +F+ Sbjct: 270 GSF-DNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMRLVLLDLYDSGFIFK 328 Query: 322 GRITPELLTRGKFNTSDVSAIEKNK-EGLHNAKEIL-TRLGVEPSDDDCVSVQHVCTIVS 379 + +L +TS S IE + E L + ++ T L +E + + ++ + +V Sbjct: 329 DQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTNLNIETTVVERKLIRKLAELVG 388 Query: 380 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRL----- 434 R+A L + AI ++ R K + DGS++ +P Y + + L+ + Sbjct: 389 TRAARLTVCGVSAICDK-RGYK-----TAHIAADGSVFNRYPGYKEKAAQALKDIYNWDV 442 Query: 435 --VPDSDVRFLLSESGSGKGAAMVTAVAY-RLA 464 + D ++ + +E GSG GAA++ + RLA Sbjct: 443 EKMEDHPIQLVAAEDGSGVGAAIIACLTQKRLA 475 >1IG8-A nrPDB Length = 486 Score = 252 bits (643), Expect = 6e-67, Method: Compositional matrix adjust. Identities = 161/449 (35%), Positives = 243/449 (54%), Gaps = 29/449 (6%) Query: 448 GSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNA 507 G K A ++A E +QIE F + + L V K +E+E GL K+ N Sbjct: 5 GPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGN-- 62 Query: 508 VVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIM 567 + M+P +V P G E+GDFLA+DLGGTN RV+LVK+ G RT + Y +P + M Sbjct: 63 -IPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKL--GGDRTFDTTQSKYRLP-DAM 118 Query: 568 QGT--GEELFDHIVSCISDFLD---YMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKG 622 + T +EL++ I + F+D GI P +PLGFTFSFP Q ++ GIL WTKG Sbjct: 119 RTTQNPDELWEFIADSLKAFIDEQFPQGISEP-IPLGFTFSFPASQNKINEGILQRWTKG 177 Query: 623 FKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGS 682 F + HDVV +L+ I +R ++VVA++NDT GT++ Y +P ++G+I GTG Sbjct: 178 FDIPNIENHDVVPMLQKQITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGV 236 Query: 683 NACYMEEMKNVEMVEG-------DQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLN 735 N Y + ++E ++G M IN E+G+F DN + RT YD +DE S Sbjct: 237 NGAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPR 295 Query: 736 AGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRL 795 G+Q +EKM SG YLGEI+R L+D K+GF+F+ Q + +T + ++IE D Sbjct: 296 PGQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPF 355 Query: 796 ALLQVRAILQQ--LGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDR 853 L+ L Q G+N+T + L++ + ++ RAA+L G+AA+ K RG Sbjct: 356 ENLEDTDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQK----RGYKT 411 Query: 854 LNVTVGVDGTLYKLHPHFSRIMHQTVKEL 882 + + DG++Y +P F +K++ Sbjct: 412 GH--IAADGSVYNRYPGFKEKAANALKDI 438 Score = 205 bits (521), Expect = 8e-53, Method: Compositional matrix adjust. Identities = 128/428 (29%), Positives = 225/428 (52%), Gaps = 25/428 (5%) Query: 19 VKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 78 +++I+ + + ETL + F E++ GLS+ + M+P +V P G E G Sbjct: 24 MQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKK---GGNIPMIPGWVMDFPTGKESG 80 Query: 79 DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENI-VHGSGSQLFDHVAECLGDF 137 DF+A+DLGG++ R++ V++ ++ + Y P+ + + +L++ +A+ L F Sbjct: 81 DFLAIDLGGTNLRVVLVKLGGDRTFDTTQSK--YRLPDAMRTTQNPDELWEFIADSLKAF 138 Query: 138 MEKRKIK--DKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKK 195 ++++ + + +P+GFTFSFP Q+KI+E IL WTK F +E DVV +L K I K Sbjct: 139 IDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITK 198 Query: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEG----- 250 R + +VA++NDT GT++ Y D ++G+I GTG N Y + I+ ++G Sbjct: 199 R-NIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDD 257 Query: 251 --DEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRL 308 M IN E+G+F D+ + RT++D ID S PG+Q FEKM SG YLGE++RL Sbjct: 258 IPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRL 316 Query: 309 ILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNK-EGLHNAKEIL-TRLGVEPSDD 366 L+ M K+G +F+ + + +TS + IE++ E L + ++ G+ + Sbjct: 317 ALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQ 376 Query: 367 DCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRR 426 + ++ + ++ R+A L + AI + G + DGS+Y +P + + Sbjct: 377 ERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTG------HIAADGSVYNRYPGFKEK 430 Query: 427 FHKTLRRL 434 L+ + Sbjct: 431 AANALKDI 438 >4QS9-A nrPDB Length = 474 Score = 246 bits (628), Expect = 3e-65, Method: Compositional matrix adjust. Identities = 156/441 (35%), Positives = 236/441 (53%), Gaps = 26/441 (5%) Query: 484 LLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLV 543 L +V M EM GL + + +KML S+V P G E G F ALDLGGTNFRV+ V Sbjct: 33 LRQVADAMTVEMHAGL--ASDGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRV 90 Query: 544 KIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFL-----DYMGIKGPRMPL 598 + ++R V+ + +IP +M G +ELF+ I ++ F+ D+ +G + L Sbjct: 91 LLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQREL 150 Query: 599 GFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDT 658 GFTF+FP +QTSL +G LI WTKGF + VG DVV L A++R D+ + A+VNDT Sbjct: 151 GFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERV-GLDMRIAALVNDT 209 Query: 659 VGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEG---DQGQMCINMEWGAFGDN 715 VGT+ Y P +I+GTG+NA Y+E + G G+M INMEWG F + Sbjct: 210 VGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNFRSS 269 Query: 716 GCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISET 775 T +D +D SLN G+Q EK+ISGMYLGEI+R +L+ + F + Sbjct: 270 HL---PLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSK 326 Query: 776 LKTRGIFETKFLSQIESD-----RLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRA 830 L+ I T +S + +D ++ +++ IL+ ++ +V ++C +++ R Sbjct: 327 LRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEV--PTTSLKMRKVVISLCNIIATRG 384 Query: 831 AQLCGAGMAAVVDKIRENRGLDR--LNVTVGVDGTLYKLHPHFSRIMHQTVKEL---SPK 885 A+L AG+ ++ K+ + D + +DG L++ + FS M ++KEL Sbjct: 385 ARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEAS 444 Query: 886 CNVSFLLSEDGSGKGAALITA 906 +V S DGSG GAAL+ A Sbjct: 445 GSVEVTHSNDGSGIGAALLAA 465 Score = 230 bits (586), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 159/437 (36%), Positives = 232/437 (53%), Gaps = 38/437 (8%) Query: 46 EMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNV 105 EM GL+ D + +KML ++V ++P G EKG F ALDLGG++FR++RV + ++ + V Sbjct: 43 EMHAGLASDGG--SKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVV 100 Query: 106 HMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLP------VGFTFSFPCQ 159 E E P +++ G +LF+ +AE L F+ + +D LP +GFTF+FP + Sbjct: 101 KQEFEEVSIPPHLMTGGSDELFNFIAEALAKFV-ATECEDFHLPEGRQRELGFTFAFPVK 159 Query: 160 QSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY 219 Q+ + LI WTK F G DVV LNKA+++ G D I A+VNDTVGT+ Y Sbjct: 160 QTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVG-LDMRIAALVNDTVGTLAGGRY 218 Query: 220 DDQHCEVGLIIGTGTNACYMEELRHIDLVEG---DEGRMCINTEWGAFGDDGSLEDIRTE 276 + +I+GTGTNA Y+E I G G M IN EWG F S TE Sbjct: 219 YNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNF---RSSHLPLTE 275 Query: 277 FDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNT 336 FD +D SLNPG+Q+ EK++SGMYLGE++R +L+KMA++ F + +L T Sbjct: 276 FDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRT 335 Query: 337 SDVSAIEKNKEGLHN-AKEILTRLGVEPSDDDCVS---------VQHVCTIVSFRSANLV 386 +SA +HN L +G + D V V +C I++ R A L Sbjct: 336 PHMSA-------MHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLS 388 Query: 387 AATLGAILNRL-RD-NKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPD---SDVR 441 AA + IL +L RD K ++ + +DG L++ + Q+S +L+ L+ D V Sbjct: 389 AAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVE 448 Query: 442 FLLSESGSGKGAAMVTA 458 S GSG GAA++ A Sbjct: 449 VTHSNDGSGIGAALLAA 465 >3B8A-X nrPDB Length = 485 Score = 243 bits (621), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 165/479 (34%), Positives = 263/479 (54%), Gaps = 38/479 (7%) Query: 459 VAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRR 518 V L ++ Q+E+ F + + L +V K E+ GL K+ N + M+P +V Sbjct: 19 VPKELMDEIHQLEDM---FTVDSETLRKVVKHFIDELNKGLTKKGGN---IPMIPGWVME 72 Query: 519 TPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTG--EELFD 576 P G E+G++LA+DLGGTN RV+LVK+ T + Y +P + M+ T EEL+ Sbjct: 73 FPTGKESGNYLAIDLGGTNLRVVLVKLSG--NHTFDTTQSKYKLPHD-MRTTKHQEELWS 129 Query: 577 HIVSCISDFL---DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDV 633 I + DF+ + + K +PLGFTFS+P Q ++ GIL WTKGF + GHDV Sbjct: 130 FIADSLKDFMVEQELLNTKD-TLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDV 188 Query: 634 VTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNV 693 V LL++ I +RE +++VA++NDTVGT++ Y +P ++G+I GTG N + + + ++ Sbjct: 189 VPLLQNEISKRE-LPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDI 247 Query: 694 EMVEG-------DQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMIS 746 E +EG M IN E+G+F DN L RT YD VDE S G+Q +EKM S Sbjct: 248 EKLEGKLADDIPSNSPMAINCEYGSF-DNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTS 306 Query: 747 GMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQ-VRAILQ 805 G YLGE++R +L++ +KG + + Q LK I +T + ++IE D L+ I Q Sbjct: 307 GYYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQ 366 Query: 806 Q-LGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTL 864 + G+ +T + L++ +C ++ RAA+L G+AA+ K G + DG++ Sbjct: 367 KDFGVKTTLPERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTG------HIAADGSV 420 Query: 865 YKLHPHFSRIMHQTVKEL------SPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 917 Y +P F + ++++ + K ++ + +EDGSG GAA+I A+ + E S Sbjct: 421 YNKYPGFKEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAALSEKRIAEGKS 479 Score = 210 bits (535), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 148/451 (32%), Positives = 243/451 (53%), Gaps = 32/451 (7%) Query: 34 ETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRIL 93 ETL ++ F E+ GL++ + M+P +V P G E G+++A+DLGG++ R++ Sbjct: 39 ETLRKVVKHFIDELNKGLTKK---GGNIPMIPGWVMEFPTGKESGNYLAIDLGGTNLRVV 95 Query: 94 RVQVNHEKNQNVHMESEVYDTPENI-VHGSGSQLFDHVAECLGDFMEKRKIKDKK--LPV 150 V+++ N Y P ++ +L+ +A+ L DFM ++++ + K LP+ Sbjct: 96 LVKLS--GNHTFDTTQSKYKLPHDMRTTKHQEELWSFIADSLKDFMVEQELLNTKDTLPL 153 Query: 151 GFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDT 210 GFTFS+P Q+KI+E IL WTK F VEG DVV LL I KR + IVA++NDT Sbjct: 154 GFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISKR-ELPIEIVALINDT 212 Query: 211 VGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEG-------DEGRMCINTEWGA 263 VGT++ Y D ++G+I GTG N + + + I+ +EG M IN E+G+ Sbjct: 213 VGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADDIPSNSPMAINCEYGS 272 Query: 264 FGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGR 323 F D+ L RT++D +D S PG+Q FEKM SG YLGEL+RL+L+++ ++GL+ + + Sbjct: 273 F-DNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLLELNEKGLMLKDQ 331 Query: 324 ITPELLTRGKFNTSDVSAIEKNK-EGLHNAKEILTR-LGVEPSDDDCVSVQHVCTIVSFR 381 +L +TS + IE + E L + +I + GV+ + + ++ +C ++ R Sbjct: 332 DLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVKTTLPERKLIRRLCELIGTR 391 Query: 382 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRL------V 435 +A L + AI + G + DGS+Y +P + K LR + Sbjct: 392 AARLAVCGIAAICQKRGYKTG------HIAADGSVYNKYPGFKEAAAKGLRDIYGWTGDA 445 Query: 436 PDSDVRFLLSESGSGKGAAMVTAVA-YRLAE 465 + + +E GSG GAA++ A++ R+AE Sbjct: 446 SKDPITIVPAEDGSGAGAAVIAALSEKRIAE 476 >2YHX-A nrPDB Length = 457 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 36/178 (20%), Positives = 75/178 (42%), Gaps = 4/178 (2%) Query: 509 VKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQ 568 + M+P +V + G + G FLA+ +GG + V+L+ + +G++ + ++ A + Sbjct: 44 IPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISL-AGRQESSIXASRSLAAAMSTTA 102 Query: 569 GTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDC 628 + + S + +PLGFTF + + G + F Sbjct: 103 IPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXL 162 Query: 629 VGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACY 686 +++ + +A + VA + D+ G + Y + ++G+I G+G NA Y Sbjct: 163 --XKLISAMXNAXFPAGDXXXS-VADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAY 217 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 34/179 (18%), Positives = 72/179 (40%), Gaps = 6/179 (3%) Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120 + M+P +V G++ G F+A+ +GG ++ + + + ++ + Sbjct: 44 IPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISLAGRQESSIXASRSLAAAMSTT-- 101 Query: 121 GSGSQLFDHVAEC-LGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASG 179 S L+ + A + +P+GFTF + + + + F + Sbjct: 102 AIPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAX 161 Query: 180 VEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACY 238 + ++ + A GD + VA + D+ G + Y D ++G+I G+G NA Y Sbjct: 162 LX--KLISAMXNAXFPAGDXXXS-VADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAY 217 >1HKG-A nrPDB Length = 457 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 37/184 (20%), Positives = 76/184 (41%), Gaps = 16/184 (8%) Query: 509 VKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY------AI 562 + M+P +V + G++ G FLA+ +GG + V+L+ + ++ ++ + AI Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAASMXTTAI 103 Query: 563 PIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKG 622 P ++ + S + +PLGFTF + + G + Sbjct: 104 PSDLWG-------NXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXA 156 Query: 623 FKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGS 682 F +++ + +A + VA + D+ G + Y + ++G+I G+G Sbjct: 157 FSLAXL--XKLISAMXNAXFPAGD-XXXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGV 213 Query: 683 NACY 686 NA Y Sbjct: 214 NAAY 217 Score = 39.3 bits (90), Expect = 0.007, Method: Compositional matrix adjust. Identities = 35/179 (19%), Positives = 71/179 (39%), Gaps = 6/179 (3%) Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120 + M+P +V GS+ G F+A+ +GG ++ + + + ++ + Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSL--AASMXTT 101 Query: 121 GSGSQLFDHVAEC-LGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASG 179 S L+ + A + +P+GFTF + + + + F + Sbjct: 102 AIPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAX 161 Query: 180 VEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACY 238 + ++ + A GD VA + D+ G + Y D ++G+I G+G NA Y Sbjct: 162 LX--KLISAMXNAXFPAGD-XXXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAY 217 >4OCK-A nrPDB Length = 379 Score = 32.3 bits (72), Expect = 1.1, Method: Compositional matrix adjust. Identities = 33/119 (27%), Positives = 48/119 (40%), Gaps = 10/119 (8%) Query: 376 TIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLV 435 T+ R+ LV +TL A D T T +DG ++ Y H LV Sbjct: 78 TVNLMRNVELVTSTLKAQGKETLDIVPTTSGATWAEIDGGAWRV---YKFIEHTVSYNLV 134 Query: 436 PDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAE 494 P+ DV E+GS G + + Q+ ET+AHFH T + K + A+ Sbjct: 135 PNPDV---FREAGSAFGDFQNFLSEFDAS----QLTETIAHFHDTPHRFEDFKAALAAD 186 >4FDG-B nrPDB Length = 692 Score = 31.2 bits (69), Expect = 2.1, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 29/59 (49%), Gaps = 2/59 (3%) Query: 837 GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSED 895 G+ V++ +R+ R D + + +DG L K+ P RI T K + P C F ED Sbjct: 108 GIPRVIE-LRKIRSTD-IGKLITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWPED 164 >3F9V-A nrPDB Length = 595 Score = 31.2 bits (69), Expect = 2.3, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 29/59 (49%), Gaps = 2/59 (3%) Query: 837 GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSED 895 G+ V++ +R+ R D + + +DG L K+ P RI T K + P C F ED Sbjct: 96 GIPRVIE-LRKIRSTD-IGKLITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWPED 152 >2WCZ-A nrPDB Length = 139 Score = 31.2 bits (69), Expect = 2.3, Method: Composition-based stats. Identities = 30/107 (28%), Positives = 45/107 (42%), Gaps = 21/107 (19%) Query: 35 TLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILR 94 T + I + RKE+ LS D V+ L TF R G+E ++AL L +R Sbjct: 49 TYLAIEVKMRKELPLYLSAD-----EVEQLVTFARGF--GAEA--YVALKLPRKKWRFFP 99 Query: 95 VQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 141 VQ+ +N ++ VY L +AE G F ++R Sbjct: 100 VQMLERTEKNFKIDESVY------------PLGLEIAEVAGKFFQER 134 >4R7Y-A nrPDB Length = 613 Score = 30.8 bits (68), Expect = 2.5, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 29/59 (49%), Gaps = 2/59 (3%) Query: 837 GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSED 895 G+ V++ +R+ R D + + +DG L K+ P RI T K + P C F ED Sbjct: 103 GIPRVIE-LRKIRSTD-IGKLITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWPED 159 >5MB9-A nrPDB Length = 590 Score = 30.0 bits (66), Expect = 4.6, Method: Compositional matrix adjust. Identities = 42/187 (22%), Positives = 73/187 (39%), Gaps = 12/187 (6%) Query: 732 YSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIE 791 Y++ A YE Y G + +LID K FL + ++ + K + E Sbjct: 241 YTILATVHDYE------YHGIALDKVLIDHFSKEFLKKNPGAKDPRENPRSLAKLRLEAE 294 Query: 792 SDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGL 851 S + AL R+ + S D T+ + A+ G +V+ + GL Sbjct: 295 STKRAL--SRSTNASFSVESLIDGLDFASTINRLRYETIARTVFEGFNRLVESAVKKAGL 352 Query: 852 DRLNV----TVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAV 907 D L+V G ++ +F I ++ + L+P + S L + +GAAL ++ Sbjct: 353 DPLDVDEVIMSGGTSNTPRIAANFRYIFPESTRILAPSTDPSALNPSELQARGAALQASL 412 Query: 908 GVRLRTE 914 TE Sbjct: 413 IQEFETE 419 >2JXP-A nrPDB Length = 155 Score = 30.0 bits (66), Expect = 5.3, Method: Composition-based stats. Identities = 25/82 (30%), Positives = 38/82 (46%), Gaps = 1/82 (1%) Query: 444 LSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDM-LLEVKKRMRAEMELGLRKQ 502 LSESG + +V VA RL + H +L LT+ + L+ ++ +A E L K Sbjct: 68 LSESGRVREFELVYRVAARLLDAHNAELASLQEIRLTRILPFLDAQELAKAAEEEMLYKD 127 Query: 503 THNNAVVKMLPSFVRRTPDGTE 524 +AV ++L T G E Sbjct: 128 MQKDAVQQILRQVSAFTSAGLE 149 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4FOI-A nrPDB 1452 0.0 1BG3-A nrPDB 1425 0.0 5HFU-A nrPDB 1370 0.0 3W0L-A nrPDB 655 0.0 4DCH-A nrPDB 635 0.0 3HM8-A nrPDB 617 e-177 3O1W-A nrPDB 584 e-167 1BDG-A nrPDB 563 e-160 1IG8-A nrPDB 559 e-159 3B8A-X nrPDB 554 e-158 5ZQT-A nrPDB 520 e-147 4QS9-A nrPDB 497 e-141 2YHX-A nrPDB 210 2e-54 Sequences not found previously or not previously below threshold: 1HKG-A nrPDB 202 7e-52 3ZR5-A nrPDB 34 0.38 2BWY-A nrPDB 32 1.1 4NK4-A nrPDB 32 2.0 1G8W-A nrPDB 30 3.8 5ZI1-A nrPDB 30 4.0 >4FOI-A nrPDB Length = 917 Score = 1452 bits (3759), Expect = 0.0, Method: Composition-based stats. Identities = 916/917 (99%), Positives = 917/917 (100%) Query: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT Sbjct: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60 Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH Sbjct: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120 Query: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV Sbjct: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180 Query: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240 Query: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300 Query: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG Sbjct: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360 Query: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 420 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGV+GSLYKTH Sbjct: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVNGSLYKTH 420 Query: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480 Query: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV Sbjct: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540 Query: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF Sbjct: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600 Query: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG Sbjct: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660 Query: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD Sbjct: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720 Query: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG Sbjct: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780 Query: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840 Query: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG Sbjct: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900 Query: 901 AALITAVGVRLRTEASS 917 AALITAVGVRLRTEASS Sbjct: 901 AALITAVGVRLRTEASS 917 >1BG3-A nrPDB Length = 918 Score = 1425 bits (3689), Expect = 0.0, Method: Composition-based stats. Identities = 850/916 (92%), Positives = 892/916 (97%) Query: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDE LIDI+TRF+KEMKNGLSRD+NPTA+ Sbjct: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTAS 60 Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNV MESE+YDTPENIVH Sbjct: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH 120 Query: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180 GSG+QLFDHVA+CLGDFMEK+KIKDKKLPVGFTFSFPC+QSKIDEA+LITWTKRFKASGV Sbjct: 121 GSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGV 180 Query: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQ CEVGLIIGTGTNACYME Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYME 240 Query: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRE+DRGSLNPGKQLFEKMVSGM Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGM 300 Query: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360 Y+GELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEK+KEG+ NAKEILTRLG Sbjct: 301 YMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLG 360 Query: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTH 420 VEPSD DCVSVQH+CTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYK H Sbjct: 361 VEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMH 420 Query: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480 PQYSRRFHKTLRRLVPDSDVRFLLSESG+GKGAAMVTAVAYRLAEQHRQIEETLAHF L+ Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS 480 Query: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540 K L+EVKKR+R EME+GLRK+T++ A VKMLPSFVR PDGTE+GDFLALDLGGTNFRV Sbjct: 481 KQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRV 540 Query: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600 LLVKIRSGKKRTVEMHNKIY+IP+EIMQGTG+ELFDHIVSCISDFLDYMGIKGPRMPLGF Sbjct: 541 LLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGF 600 Query: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660 TFSFPC QT+LD GILI+WTKGFKATDC GHDV +LLRDA+KRREEFDLDVVAVVNDTVG Sbjct: 601 TFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVG 660 Query: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720 TMMTCAYEEPTCE+GLIVGTG+NACYMEEMKNVEMVEG+QGQMCINMEWGAFGDNGCLDD Sbjct: 661 TMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDD 720 Query: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780 IRT +D++VDEYSLN+GKQR+EKMISGMYLGEIVRNILIDFTKKGFLFRGQISE LKTRG Sbjct: 721 IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG 780 Query: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVS+RAAQLCGAGMAA Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA 840 Query: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900 VV+KIRENRGLD LNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKC VSFLLSEDGSGKG Sbjct: 841 VVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKG 900 Query: 901 AALITAVGVRLRTEAS 916 AALITAVGVRLR + S Sbjct: 901 AALITAVGVRLRGDPS 916 >5HFU-A nrPDB Length = 923 Score = 1370 bits (3546), Expect = 0.0, Method: Composition-based stats. Identities = 662/900 (73%), Positives = 780/900 (86%) Query: 17 DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76 DQV+K+D+YLY MRLSDETL++I RFRKEM+ GL +PTA VKMLPTFVRS PDG+E Sbjct: 23 DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 82 Query: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGD 136 G+F+ALDLGG++FR+L V+V Q V ME+++Y PE+I+ GSG+QLFDH+AECL + Sbjct: 83 HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 142 Query: 137 FMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKR 196 FM+K +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGVEG DVV L+ KAI++R Sbjct: 143 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 202 Query: 197 GDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256 GD+D +IVAVVNDTVGTMMTCGYDD +CE+GLI+GTG+NACYMEE+RHID+VEGDEGRMC Sbjct: 203 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC 262 Query: 257 INTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKE 316 IN EWGAFGDDGSL DIRTEFD+EID GSLNPGKQLFEKM+SGMY+GELVRLILVKMAKE Sbjct: 263 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 322 Query: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCT 376 LLF G+++PELL G+F T D+S IE K+G+ A+E+L RLG++P+ +DCV+ +C Sbjct: 323 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ 382 Query: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVP 436 IVS RSA+L AATL A+L R+++NKG RLR+T+GVDGS+YK HP +++R HKT+RRLVP Sbjct: 383 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP 442 Query: 437 DSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEME 496 DVRFL SE GSGKGAAMVTAVAYRLA+QHR ++TL H L+ D LLEVK+RM+ EME Sbjct: 443 GCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEME 502 Query: 497 LGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMH 556 GL K+TH +A VKMLP++V TPDGTE GDFLALDLGGTNFRVLLV++R+GK VEMH Sbjct: 503 RGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMH 562 Query: 557 NKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGIL 616 NKIYAIP E+M GTG+ELFDHIV CI+DFL+YMG+KG +PLGFTFSFPCQQ SLD IL Sbjct: 563 NKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESIL 622 Query: 617 ITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGL 676 + WTKGFKA+ C G DVVTLL++AI RREEFDLDVVAVVNDTVGTMMTC +E+P CEVGL Sbjct: 623 LKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGL 682 Query: 677 IVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNA 736 IVGTGSNACYMEEM+NVE+VEG++G+MC+NMEWGAFGDNGCLDD RT +D VDE SLN Sbjct: 683 IVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNP 742 Query: 737 GKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLA 796 GKQR+EKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRGIFETKFLSQIESD LA Sbjct: 743 GKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLA 802 Query: 797 LLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNV 856 LLQVRAILQ LGL STCDDSI+VK VC VV+RRAAQLCGAGMAAVVD+IRENRGLD L V Sbjct: 803 LLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKV 862 Query: 857 TVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEAS 916 TVGVDGTLYKLHPHF+++MH+TVK+L+PKC+VSFL SEDGSGKGAALITAV R+R Sbjct: 863 TVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQ 922 Score = 572 bits (1475), Expect = e-163, Method: Composition-based stats. Identities = 258/448 (57%), Positives = 345/448 (77%) Query: 464 AEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGT 523 ++Q +++++ L H L+ + LLE+ KR R EME GL TH A VKMLP+FVR TPDGT Sbjct: 22 SDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGT 81 Query: 524 ENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCIS 583 E+G+FLALDLGGTNFRVL VK+ + VEM N+IYAIP +IM+G+G +LFDHI C++ Sbjct: 82 EHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLA 141 Query: 584 DFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKR 643 +F+D + IK ++PLGFTFSFPC QT LD L++WTKGFK++ G DVV L+R AI+R Sbjct: 142 NFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQR 201 Query: 644 REEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQM 703 R +FD+D+VAVVNDTVGTMMTC Y++ CE+GLIVGTGSNACYMEEM++++MVEGD+G+M Sbjct: 202 RGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRM 261 Query: 704 CINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTK 763 CINMEWGAFGD+G L+DIRT +D+ +D SLN GKQ +EKMISGMY+GE+VR IL+ K Sbjct: 262 CINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAK 321 Query: 764 KGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVC 823 + LF G++S L G FETK +S IE ++ + + R +L +LGL+ T +D + +C Sbjct: 322 EELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRIC 381 Query: 824 GVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELS 883 +VS R+A LC A +AAV+ +I+EN+G +RL T+GVDG++YK HPHF++ +H+TV+ L Sbjct: 382 QIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLV 441 Query: 884 PKCNVSFLLSEDGSGKGAALITAVGVRL 911 P C+V FL SEDGSGKGAA++TAV RL Sbjct: 442 PGCDVRFLRSEDGSGKGAAMVTAVAYRL 469 >3W0L-A nrPDB Length = 458 Score = 655 bits (1689), Expect = 0.0, Method: Composition-based stats. Identities = 231/446 (51%), Positives = 318/446 (71%), Gaps = 2/446 (0%) Query: 21 KIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 80 ++D+ L L +E L +M R + EM+ GL + N A+VKMLPT+VRS PDGSE GDF Sbjct: 8 EVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVGDF 67 Query: 81 IALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM 138 +ALDLGG++FR++ V+V E V + ++Y P + + G+ LFD++AEC+ D++ Sbjct: 68 LALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIAECISDYL 127 Query: 139 EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD 198 +++ +K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RGD Sbjct: 128 DQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGD 187 Query: 199 YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 258 ++ ++VA+VNDTV TM++C Y+D HCEVGLI+GTG NACYMEE+ +++LVEG+EGRMC+N Sbjct: 188 FEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGEEGRMCVN 247 Query: 259 TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL 318 TEWGAFGD G LED R E+DR +D SLNPG+QL+EKM+ G Y+GELVRL+L+KM E L Sbjct: 248 TEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNENL 307 Query: 319 LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV 378 LF G + +L TRG F T VS IE + IL LGV+ + DC +V+ C V Sbjct: 308 LFGGESSEKLKTRGAFETQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAVRLACESV 367 Query: 379 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS 438 S R+A + +A L ILNR+R ++ LR TVGVDGS+YK HP + +FH T+ +L Sbjct: 368 STRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATVLKLTSGC 427 Query: 439 DVRFLLSESGSGKGAAMVTAVAYRLA 464 ++ F+ SE GSG+GAA+++AVAY++A Sbjct: 428 EITFIQSEEGSGRGAALISAVAYKMA 453 Score = 632 bits (1629), Expect = 0.0, Method: Composition-based stats. Identities = 246/447 (55%), Positives = 329/447 (73%), Gaps = 2/447 (0%) Query: 467 HRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENG 526 ++++ L+ FHL ++ L + RM+AEME GL +T+ A VKMLP++VR TPDG+E G Sbjct: 6 QNEVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVG 65 Query: 527 DFLALDLGGTNFRVLLVKIRSG--KKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 584 DFLALDLGGTNFRV+LVK+ + VE +K+Y+IP++ M GT E LFD+I CISD Sbjct: 66 DFLALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIAECISD 125 Query: 585 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 644 +LD +K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAIKRR Sbjct: 126 YLDQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRR 185 Query: 645 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 704 +F++DVVA+VNDTV TM++C YE+ CEVGLIVGTG NACYMEEM NVE+VEG++G+MC Sbjct: 186 GDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGEEGRMC 245 Query: 705 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 764 +N EWGAFGD G L+D R YDR+VDE SLN G+Q YEKMI G Y+GE+VR +LI + Sbjct: 246 VNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNE 305 Query: 765 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 824 LF G+ SE LKTRG FET+F+SQIE+D Q IL+ LG+ +T D V+ C Sbjct: 306 NLLFGGESSEKLKTRGAFETQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAVRLACE 365 Query: 825 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 884 VS RAA +C AG+A +++++R++R + L +TVGVDG++YKLHP F H TV +L+ Sbjct: 366 SVSTRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATVLKLTS 425 Query: 885 KCNVSFLLSEDGSGKGAALITAVGVRL 911 C ++F+ SE+GSG+GAALI+AV ++ Sbjct: 426 GCEITFIQSEEGSGRGAALISAVAYKM 452 >4DCH-A nrPDB Length = 473 Score = 635 bits (1639), Expect = 0.0, Method: Composition-based stats. Identities = 225/454 (49%), Positives = 325/454 (71%), Gaps = 2/454 (0%) Query: 20 KKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGD 79 +K+++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE GD Sbjct: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73 Query: 80 FIALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDF 137 F++LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ DF Sbjct: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133 Query: 138 MEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRG 197 ++K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RG Sbjct: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193 Query: 198 DYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCI 257 D++ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+ Sbjct: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 253 Query: 258 NTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEG 317 NTEWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ E Sbjct: 254 NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 313 Query: 318 LLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTI 377 LLF G + +L TRG F T VS +E + IL+ LG+ PS DC V+ C Sbjct: 314 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 373 Query: 378 VSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPD 437 VS R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RFH ++RRL P Sbjct: 374 VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPS 433 Query: 438 SDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIE 471 ++ F+ SE GSG+GAA+V+AVA + A Q+E Sbjct: 434 CEITFIESEEGSGRGAALVSAVACKKACMLGQLE 467 Score = 618 bits (1593), Expect = e-177, Method: Composition-based stats. Identities = 245/453 (54%), Positives = 334/453 (73%), Gaps = 2/453 (0%) Query: 460 AYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRT 519 A A + ++E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR T Sbjct: 6 ARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRST 65 Query: 520 PDGTENGDFLALDLGGTNFRVLLVKIRSG--KKRTVEMHNKIYAIPIEIMQGTGEELFDH 577 P+G+E GDFL+LDLGGTNFRV+LVK+ G + +V+ +++Y+IP + M GT E LFD+ Sbjct: 66 PEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDY 125 Query: 578 IVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLL 637 I CISDFLD +K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LL Sbjct: 126 ISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLL 185 Query: 638 RDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVE 697 RDAIKRR +F++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VE Sbjct: 186 RDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVE 245 Query: 698 GDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNI 757 GD+G+MC+N EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR + Sbjct: 246 GDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLV 305 Query: 758 LIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSI 817 L+ + LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D Sbjct: 306 LLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCD 365 Query: 818 LVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQ 877 +V+ C VS RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H Sbjct: 366 IVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHA 425 Query: 878 TVKELSPKCNVSFLLSEDGSGKGAALITAVGVR 910 +V+ L+P C ++F+ SE+GSG+GAAL++AV + Sbjct: 426 SVRRLTPSCEITFIESEEGSGRGAALVSAVACK 458 >3HM8-A nrPDB Length = 445 Score = 617 bits (1592), Expect = e-177, Method: Composition-based stats. Identities = 232/449 (51%), Positives = 308/449 (68%), Gaps = 7/449 (1%) Query: 20 KKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGD 79 + +++ L RL+ + L + + RK M GL ++++MLPTFVR+ PDGSE+GD Sbjct: 4 RLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLR---GEASSLRMLPTFVRATPDGSERGD 60 Query: 80 FIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 139 F+ALDLGG++FR+L V+V V + SE+Y PE + GSG QLFDH+ +C+ DF + Sbjct: 61 FLALDLGGTNFRVLLVRVTT----GVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQ 116 Query: 140 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 199 K+ + + LP+GFTFSFPC+Q +D+ IL+ WTK FKAS EG DVV LL +AI +R Sbjct: 117 KQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAV 176 Query: 200 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 259 + N+VA+VNDTVGTMM+CGY+D CE+GLI+GTGTNACYMEELR++ V GD GRMCIN Sbjct: 177 ELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINM 236 Query: 260 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 319 EWGAFGDDGSL + T FD +D+ S+NPGKQ FEKM+SGMYLGE+VR IL+ + G+L Sbjct: 237 EWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVL 296 Query: 320 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 379 F G+ L TR F T +S IE + L + IL LG+ + DD + V VC VS Sbjct: 297 FRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVS 356 Query: 380 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 439 R+A L A + A++ ++R+N+G L +VGVDG+LYK HP++S T+R L P Sbjct: 357 QRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCV 416 Query: 440 VRFLLSESGSGKGAAMVTAVAYRLAEQHR 468 V FL SE GSGKGAA+VTAVA RLA+ R Sbjct: 417 VTFLQSEDGSGKGAALVTAVACRLAQLTR 445 Score = 617 bits (1590), Expect = e-177, Method: Composition-based stats. Identities = 285/445 (64%), Positives = 351/445 (78%), Gaps = 7/445 (1%) Query: 467 HRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENG 526 R +EETLA F L D L V+ +MR M GLR + ++MLP+FVR TPDG+E G Sbjct: 3 RRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLR---GEASSLRMLPTFVRATPDGSERG 59 Query: 527 DFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFL 586 DFLALDLGGTNFRVLLV++ +G V++ ++IY+IP + QG+G++LFDHIV CI DF Sbjct: 60 DFLALDLGGTNFRVLLVRVTTG----VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQ 115 Query: 587 DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREE 646 G+ G +PLGFTFSFPC+Q LD GIL+ WTKGFKA+DC G DVV+LLR+AI RR+ Sbjct: 116 QKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQA 175 Query: 647 FDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCIN 706 +L+VVA+VNDTVGTMM+C YE+P CE+GLIVGTG+NACYMEE++NV V GD G+MCIN Sbjct: 176 VELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCIN 235 Query: 707 MEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGF 766 MEWGAFGD+G L + T +D VD+ S+N GKQR+EKMISGMYLGEIVR+IL+ T G Sbjct: 236 MEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGV 295 Query: 767 LFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVV 826 LFRGQ + L+TR IF+TKFLS+IESD LAL QVRAIL+ LGL T DD+++V VC V Sbjct: 296 LFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAV 355 Query: 827 SRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKC 886 S+RAAQLCGAG+AAVV+KIRENRGL+ L V+VGVDGTLYKLHP FS ++ TV+EL+P+C Sbjct: 356 SQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRC 415 Query: 887 NVSFLLSEDGSGKGAALITAVGVRL 911 V+FL SEDGSGKGAAL+TAV RL Sbjct: 416 VVTFLQSEDGSGKGAALVTAVACRL 440 >3O1W-A nrPDB Length = 485 Score = 584 bits (1506), Expect = e-167, Method: Composition-based stats. Identities = 166/488 (34%), Positives = 259/488 (53%), Gaps = 31/488 (6%) Query: 448 GSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNA 507 G K A ++A A QI F ++ + + + K +E++ GL K+ N Sbjct: 5 GPKKPPARKGSMADVPANLMEQIHGLETLFTVSSEKMRSIVKHFISELDKGLSKKGGN-- 62 Query: 508 VVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIM 567 + M+P +V P G E GDFLALDLGGTN RV+LVK+ G + Y +P + Sbjct: 63 -IPMIPGWVVEYPTGKETGDFLALDLGGTNLRVVLVKL--GGNHDFDTTQNKYRLPDHLR 119 Query: 568 QGTGEELFDHIVSCISDFLDYMGIKGPR--MPLGFTFSFPCQQTSLDAGILITWTKGFKA 625 GT E+L+ I C+ +F+D G +PLGFTFS+P Q +++G+L WTKGF Sbjct: 120 TGTSEQLWSFIAKCLKEFVDEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDI 179 Query: 626 TDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNAC 685 GHDVV +L++ I++ ++VVA++NDT GT++ Y +P ++G+I+GTG N Sbjct: 180 EGVEGHDVVPMLQEQIEKLN-IPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGA 238 Query: 686 YMEEMKNVEMVEG-------DQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGK 738 Y + + +E +EG M IN E+G+F DN L RT YD ++DE S G+ Sbjct: 239 YYDVVSGIEKLEGLLPEDIGPDSPMAINCEYGSF-DNEHLVLPRTKYDVIIDEESPRPGQ 297 Query: 739 QRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALL 798 Q +EKM SG YLGEI+R +L+D GF+F+ Q LK + +T + S+IE D L Sbjct: 298 QAFEKMTSGYYLGEIMRLVLLDLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENL 357 Query: 799 QVRAILQQLGLN--STCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNV 856 + L + LN +T + L++ + +V RAA+L G++A+ DK RG + Sbjct: 358 EDTDDLFKTNLNIETTVVERKLIRKLAELVGTRAARLTVCGVSAICDK----RGYKTAH- 412 Query: 857 TVGVDGTLYKLHPHFSRIMHQTVKELS-------PKCNVSFLLSEDGSGKGAALITAVGV 909 + DG+++ +P + Q +K++ + + +EDGSG GAA+I + Sbjct: 413 -IAADGSVFNRYPGYKEKAAQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIACLTQ 471 Query: 910 RLRTEASS 917 + S Sbjct: 472 KRLAAGKS 479 Score = 555 bits (1431), Expect = e-158, Method: Composition-based stats. Identities = 146/462 (31%), Positives = 246/462 (53%), Gaps = 31/462 (6%) Query: 19 VKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 78 +++I +S E + I+ F E+ GLS+ + M+P +V P G E G Sbjct: 24 MEQIHGLETLFTVSSEKMRSIVKHFISELDKGLSKK---GGNIPMIPGWVVEYPTGKETG 80 Query: 79 DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM 138 DF+ALDLGG++ R++ V++ N + Y P+++ G+ QL+ +A+CL +F+ Sbjct: 81 DFLALDLGGTNLRVVLVKLGG--NHDFDTTQNKYRLPDHLRTGTSEQLWSFIAKCLKEFV 138 Query: 139 EKRKIK--DKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKR 196 ++ + LP+GFTFS+P Q KI+ +L WTK F GVEG DVV +L + I+K Sbjct: 139 DEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVPMLQEQIEKL 198 Query: 197 GDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEG------ 250 + N+VA++NDT GT++ Y D ++G+IIGTG N Y + + I+ +EG Sbjct: 199 -NIPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEKLEGLLPEDI 257 Query: 251 -DEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLI 309 + M IN E+G+F D+ L RT++D ID S PG+Q FEKM SG YLGE++RL+ Sbjct: 258 GPDSPMAINCEYGSF-DNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMRLV 316 Query: 310 LVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNK-EGLHNAKEIL-TRLGVEPSDDD 367 L+ + G +F+ + +L +TS S IE + E L + ++ T L +E + + Sbjct: 317 LLDLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTNLNIETTVVE 376 Query: 368 CVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRF 427 ++ + +V R+A L + AI ++ + DGS++ +P Y + Sbjct: 377 RKLIRKLAELVGTRAARLTVCGVSAICDKRGYKT------AHIAADGSVFNRYPGYKEKA 430 Query: 428 HKTLRRL-------VPDSDVRFLLSESGSGKGAAMVTAVAYR 462 + L+ + + D ++ + +E GSG GAA++ + + Sbjct: 431 AQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIACLTQK 472 >1BDG-A nrPDB Length = 451 Score = 563 bits (1450), Expect = e-160, Method: Composition-based stats. Identities = 193/458 (42%), Positives = 279/458 (60%), Gaps = 20/458 (4%) Query: 14 LKDDQV-KKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIP 72 D Q+ +K+ + L LS +I R + M+ GL + N +++KM P++V P Sbjct: 3 FSDQQLFEKVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTP 62 Query: 73 DGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAE 132 +G+E G+F+ALDLGG+++R+L V + + ++ ++ Y P + GSG++LF ++AE Sbjct: 63 NGTETGNFLALDLGGTNYRVLSVTLEGKG-KSPRIQERTYCIPAEKMSGSGTELFKYIAE 121 Query: 133 CLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKA 192 L DF+E +KDKK +GFTFSFPC Q + A L+ WTK F A GVEG +V +LL Sbjct: 122 TLADFLENNGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTE 181 Query: 193 IKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEG-D 251 + KR + + VAVVNDTVGT+ +C +D C VGLI+GTGTN Y+E+ ++L++G Sbjct: 182 LDKR-ELNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVK 240 Query: 252 EGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILV 311 E + INTEWGAFG+ G L+ RT+FD+ +D SL+PGKQL+EKMVSGMYLGELVR I+V Sbjct: 241 EPEVVINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIV 300 Query: 312 KMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEG-LHNAKEILTR----LGVEPSDD 366 + ++ +LF G + L R T ++ +E++ L+N +LT VEP D+ Sbjct: 301 YLVEQKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDN 360 Query: 367 DCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRR 426 V++ C +V R+A L A + IL R+ R TVGVDGSLYK HP++ R Sbjct: 361 --RIVRYACEMVVKRAAYLAGAGIACILRRIN------RSEVTVGVDGSLYKFHPKFCER 412 Query: 427 FHKTLRRLVPDSDVRFL--LSESGSGKGAAMVTAVAYR 462 + +L P + RF LSE GSGKGAA + A R Sbjct: 413 MTDMVDKLKPK-NTRFCLRLSEDGSGKGAAAIAASCTR 449 Score = 554 bits (1429), Expect = e-158, Method: Composition-based stats. Identities = 207/452 (45%), Positives = 283/452 (62%), Gaps = 15/452 (3%) Query: 465 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 524 + ++ E L F L+ E+ RM M LGL+K T+ + +KM PS+V +TP+GTE Sbjct: 7 QLFEKVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTE 66 Query: 525 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 584 G+FLALDLGGTN+RVL V + GK ++ + + Y IP E M G+G ELF +I ++D Sbjct: 67 TGNFLALDLGGTNYRVLSVTL-EGKGKSPRIQERTYCIPAEKMSGSGTELFKYIAETLAD 125 Query: 585 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 644 FL+ G+K + LGFTFSFPC Q L L+ WTKGF A GH+V LL+ + +R Sbjct: 126 FLENNGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKR 185 Query: 645 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEG-DQGQM 703 E ++ VAVVNDTVGT+ +CA E+P C VGLIVGTG+N Y+E+ VE+++G + ++ Sbjct: 186 E-LNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVKEPEV 244 Query: 704 CINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTK 763 IN EWGAFG+ G LD RT +D+ +D SL+ GKQ YEKM+SGMYLGE+VR+I++ + Sbjct: 245 VINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLVE 304 Query: 764 KGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSI---LVK 820 + LFRG + E LK R T++L+ +E D LL + L+ + I +V+ Sbjct: 305 QKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDNRIVR 364 Query: 821 TVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVK 880 C +V +RAA L GAG+A ++ R ++R VTVGVDG+LYK HP F M V Sbjct: 365 YACEMVVKRAAYLAGAGIACIL------RRINRSEVTVGVDGSLYKFHPKFCERMTDMVD 418 Query: 881 ELSPKCNVSFL--LSEDGSGKGAALITAVGVR 910 +L PK N F LSEDGSGKGAA I A R Sbjct: 419 KLKPK-NTRFCLRLSEDGSGKGAAAIAASCTR 449 >1IG8-A nrPDB Length = 486 Score = 559 bits (1441), Expect = e-159, Method: Composition-based stats. Identities = 170/490 (34%), Positives = 258/490 (52%), Gaps = 34/490 (6%) Query: 448 GSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNA 507 G K A ++A E +QIE F + + L V K +E+E GL K+ N Sbjct: 5 GPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGN-- 62 Query: 508 VVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIM 567 + M+P +V P G E+GDFLA+DLGGTN RV+LVK+ G RT + Y +P + M Sbjct: 63 -IPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKL--GGDRTFDTTQSKYRLP-DAM 118 Query: 568 QGT--GEELFDHIVSCISDFLDYMGIKGPR--MPLGFTFSFPCQQTSLDAGILITWTKGF 623 + T +EL++ I + F+D +G +PLGFTFSFP Q ++ GIL WTKGF Sbjct: 119 RTTQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGF 178 Query: 624 KATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSN 683 + HDVV +L+ I +R ++VVA++NDT GT++ Y +P ++G+I GTG N Sbjct: 179 DIPNIENHDVVPMLQKQITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVN 237 Query: 684 ACYMEEMKNVEMVEG-------DQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNA 736 Y + ++E ++G M IN E+G+F DN + RT YD +DE S Sbjct: 238 GAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRP 296 Query: 737 GKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLA 796 G+Q +EKM SG YLGEI+R L+D K+GF+F+ Q + +T + ++IE D Sbjct: 297 GQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFE 356 Query: 797 LLQVRAILQQ--LGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRL 854 L+ L Q G+N+T + L++ + ++ RAA+L G+AA+ K G Sbjct: 357 NLEDTDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTG---- 412 Query: 855 NVTVGVDGTLYKLHPHFSRIMHQTVKELS-------PKCNVSFLLSEDGSGKGAALITAV 907 + DG++Y +P F +K++ + + +EDGSG GAA+I A+ Sbjct: 413 --HIAADGSVYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAAL 470 Query: 908 GVRLRTEASS 917 + E S Sbjct: 471 AQKRIAEGKS 480 Score = 543 bits (1398), Expect = e-154, Method: Composition-based stats. Identities = 130/448 (29%), Positives = 230/448 (51%), Gaps = 32/448 (7%) Query: 19 VKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 78 +++I+ + + ETL + F E++ GLS+ + M+P +V P G E G Sbjct: 24 MQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKK---GGNIPMIPGWVMDFPTGKESG 80 Query: 79 DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENI-VHGSGSQLFDHVAECLGDF 137 DF+A+DLGG++ R++ V++ + + Y P+ + + +L++ +A+ L F Sbjct: 81 DFLAIDLGGTNLRVVLVKLGGD--RTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAF 138 Query: 138 MEKRKIK--DKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKK 195 ++++ + + +P+GFTFSFP Q+KI+E IL WTK F +E DVV +L K I K Sbjct: 139 IDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITK 198 Query: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEG----- 250 R + +VA++NDT GT++ Y D ++G+I GTG N Y + I+ ++G Sbjct: 199 R-NIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDD 257 Query: 251 --DEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRL 308 M IN E+G+F D+ + RT++D ID S PG+Q FEKM SG YLGE++RL Sbjct: 258 IPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRL 316 Query: 309 ILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNK-EGLHNAKEILTR-LGVEPSDD 366 L+ M K+G +F+ + + +TS + IE++ E L + ++ G+ + Sbjct: 317 ALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQ 376 Query: 367 DCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRR 426 + ++ + ++ R+A L + AI + G + DGS+Y +P + + Sbjct: 377 ERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTG------HIAADGSVYNRYPGFKEK 430 Query: 427 FHKTLRRLVP-------DSDVRFLLSES 447 L+ + D ++ + +E Sbjct: 431 AANALKDIYGWTQTSLDDYPIKIVPAED 458 >3B8A-X nrPDB Length = 485 Score = 554 bits (1427), Expect = e-158, Method: Composition-based stats. Identities = 163/488 (33%), Positives = 260/488 (53%), Gaps = 31/488 (6%) Query: 448 GSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNA 507 G K A ++A E +I + F + + L +V K E+ GL K+ N Sbjct: 5 GPKKPQARKGSMADVPKELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGLTKKGGN-- 62 Query: 508 VVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIM 567 + M+P +V P G E+G++LA+DLGGTN RV+LVK+ T + Y +P ++ Sbjct: 63 -IPMIPGWVMEFPTGKESGNYLAIDLGGTNLRVVLVKLSG--NHTFDTTQSKYKLPHDMR 119 Query: 568 QGT-GEELFDHIVSCISDFL--DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFK 624 EEL+ I + DF+ + +PLGFTFS+P Q ++ GIL WTKGF Sbjct: 120 TTKHQEELWSFIADSLKDFMVEQELLNTKDTLPLGFTFSYPASQNKINEGILQRWTKGFD 179 Query: 625 ATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNA 684 + GHDVV LL++ I +RE +++VA++NDTVGT++ Y +P ++G+I GTG N Sbjct: 180 IPNVEGHDVVPLLQNEISKRE-LPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNG 238 Query: 685 CYMEEMKNVEMVEGD-------QGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAG 737 + + + ++E +EG M IN E+G+F DN L RT YD VDE S G Sbjct: 239 AFYDVVSDIEKLEGKLADDIPSNSPMAINCEYGSF-DNEHLVLPRTKYDVAVDEQSPRPG 297 Query: 738 KQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLAL 797 +Q +EKM SG YLGE++R +L++ +KG + + Q LK I +T + ++IE D Sbjct: 298 QQAFEKMTSGYYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFEN 357 Query: 798 LQVRAILQQ--LGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLN 855 L+ + Q G+ +T + L++ +C ++ RAA+L G+AA+ K G Sbjct: 358 LEDTDDIFQKDFGVKTTLPERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTG----- 412 Query: 856 VTVGVDGTLYKLHPHFSRIMHQTVKEL------SPKCNVSFLLSEDGSGKGAALITAVGV 909 + DG++Y +P F + ++++ + K ++ + +EDGSG GAA+I A+ Sbjct: 413 -HIAADGSVYNKYPGFKEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAALSE 471 Query: 910 RLRTEASS 917 + E S Sbjct: 472 KRIAEGKS 479 Score = 527 bits (1357), Expect = e-150, Method: Composition-based stats. Identities = 146/462 (31%), Positives = 244/462 (52%), Gaps = 31/462 (6%) Query: 19 VKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 78 + +I + + ETL ++ F E+ GL++ + M+P +V P G E G Sbjct: 24 MDEIHQLEDMFTVDSETLRKVVKHFIDELNKGLTKK---GGNIPMIPGWVMEFPTGKESG 80 Query: 79 DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENI-VHGSGSQLFDHVAECLGDF 137 +++A+DLGG++ R++ V+++ N Y P ++ +L+ +A+ L DF Sbjct: 81 NYLAIDLGGTNLRVVLVKLSG--NHTFDTTQSKYKLPHDMRTTKHQEELWSFIADSLKDF 138 Query: 138 MEKRKIKDKK--LPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKK 195 M ++++ + K LP+GFTFS+P Q+KI+E IL WTK F VEG DVV LL I K Sbjct: 139 MVEQELLNTKDTLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISK 198 Query: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGD---- 251 R + IVA++NDTVGT++ Y D ++G+I GTG N + + + I+ +EG Sbjct: 199 R-ELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADD 257 Query: 252 ---EGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRL 308 M IN E+G+F D+ L RT++D +D S PG+Q FEKM SG YLGEL+RL Sbjct: 258 IPSNSPMAINCEYGSF-DNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRL 316 Query: 309 ILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNK-EGLHNAKEILT-RLGVEPSDD 366 +L+++ ++GL+ + + +L +TS + IE + E L + +I GV+ + Sbjct: 317 VLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVKTTLP 376 Query: 367 DCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRR 426 + ++ +C ++ R+A L + AI + G + DGS+Y +P + Sbjct: 377 ERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTG------HIAADGSVYNKYPGFKEA 430 Query: 427 FHKTLRRL------VPDSDVRFLLSESGSGKGAAMVTAVAYR 462 K LR + + + +E GSG GAA++ A++ + Sbjct: 431 AAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAALSEK 472 >5ZQT-A nrPDB Length = 473 Score = 520 bits (1339), Expect = e-147, Method: Composition-based stats. Identities = 177/456 (38%), Positives = 243/456 (53%), Gaps = 24/456 (5%) Query: 470 IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFL 529 IEE F +L + M EME GLR H A +KML S+V P G E+G F Sbjct: 16 IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYVDNLPTGDEHGLFY 73 Query: 530 ALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFL--- 586 ALDLGGTNFRV+ V++ +KR V + AIP +M GT ELFD I + + F+ Sbjct: 74 ALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTE 133 Query: 587 --DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 644 D+ +G + LGFTFSFP QTS+ +G LI WTKGF VG DVV L A++ R Sbjct: 134 GEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME-R 192 Query: 645 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEG---DQG 701 + D+ V A+VNDTVGT+ Y + +I+GTG+NA Y+E + G G Sbjct: 193 QGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSG 252 Query: 702 QMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDF 761 M INMEWG F R+ YD +D SLN G+Q YEKMISGMYLGEIVR IL+ Sbjct: 253 NMVINMEWGNFKSER---LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKL 309 Query: 762 TKKGFLFRGQISETLKTRGIFETKFLSQIESDRLA-LLQVRAILQQ-LGL-NSTCDDSIL 818 LF + L+ R I T +S + D L + A L+ LG+ +++ + + Sbjct: 310 AHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYI 369 Query: 819 VKTVCGVVSRRAAQLCGAGMAAVVDKIRENR----GLDRLNVTVGVDGTLYKLHPHFSRI 874 VC +V+ R A+L AG+ ++ K+ +R G + + +DG LY+ + F Sbjct: 370 TLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTC 429 Query: 875 MHQTVKEL---SPKCNVSFLLSEDGSGKGAALITAV 907 + T+ +L +V L+ DGSG GAAL+ A Sbjct: 430 LEATLADLLGEEAASSVVVKLANDGSGIGAALLAAS 465 Score = 514 bits (1324), Expect = e-146, Method: Composition-based stats. Identities = 167/458 (36%), Positives = 251/458 (54%), Gaps = 30/458 (6%) Query: 22 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 81 I++ L I +EM+ GL D P A +KML ++V ++P G E G F Sbjct: 16 IEEVEQRFSTPTALLRGIADAMVEEMERGLRAD--PHAPLKMLISYVDNLPTGDEHGLFY 73 Query: 82 ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 141 ALDLGG++FR++RVQ+ + + V + E P +++ G+ +LFD +A L F+ K Sbjct: 74 ALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFV-KT 132 Query: 142 KIKDKKLP------VGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKK 195 + +D LP +GFTFSFP Q+ I LI WTK F +G G DVV L++A+++ Sbjct: 133 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMER 192 Query: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEG---DE 252 +G D + A+VNDTVGT+ Y D +I+GTGTNA Y+E I G Sbjct: 193 QG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 251 Query: 253 GRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVK 312 G M IN EWG F + R+++D +D SLNPG+Q++EKM+SGMYLGE+VR IL+K Sbjct: 252 GNMVINMEWGNFKSER---LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLK 308 Query: 313 MAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTR----LGVEPSDDDC 368 +A + LF + +L R T D+SA+ + H+ K + + LGV + + Sbjct: 309 LAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTS--HDLKHLGAKLKDILGVADTSLEA 366 Query: 369 VSVQ-HVCTIVSFRSANLVAATLGAILNRLRDNK----GTPRLRTTVGVDGSLYKTHPQY 423 + HVC +V+ R A L AA + IL +L ++ G+ + RT + +DG LY+ + ++ Sbjct: 367 RYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKF 426 Query: 424 SRRFHKTLRRLVPD---SDVRFLLSESGSGKGAAMVTA 458 TL L+ + S V L+ GSG GAA++ A Sbjct: 427 RTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAA 464 >4QS9-A nrPDB Length = 474 Score = 497 bits (1280), Expect = e-141, Method: Composition-based stats. Identities = 156/456 (34%), Positives = 236/456 (51%), Gaps = 26/456 (5%) Query: 470 IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFL 529 ++ L +V M EM GL + +KML S+V P G E G F Sbjct: 19 LKAFEEDCATPISKLRQVADAMTVEMHAGLASDGG--SKLKMLISYVDNLPSGDEKGLFY 76 Query: 530 ALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFL--- 586 ALDLGGTNFRV+ V + ++R V+ + +IP +M G +ELF+ I ++ F+ Sbjct: 77 ALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATE 136 Query: 587 --DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 644 D+ +G + LGFTF+FP +QTSL +G LI WTKGF + VG DVV L A++R Sbjct: 137 CEDFHLPEGRQRELGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERV 196 Query: 645 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEG---DQG 701 D+ + A+VNDTVGT+ Y P +I+GTG+NA Y+E + G G Sbjct: 197 G-LDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSG 255 Query: 702 QMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDF 761 +M INMEWG F + T +D +D SLN G+Q EK+ISGMYLGEI+R +L+ Sbjct: 256 EMVINMEWGNFRSSH---LPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKM 312 Query: 762 TKKGFLFRGQISETLKTRGIFETKFLSQIESDR-----LALLQVRAILQQLGLNSTCDDS 816 + F + L+ I T +S + +D + +++ IL+ ++ Sbjct: 313 AEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEV--PTTSLKMR 370 Query: 817 ILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDR--LNVTVGVDGTLYKLHPHFSRI 874 +V ++C +++ R A+L AG+ ++ K+ + D + +DG L++ + FS Sbjct: 371 KVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSEC 430 Query: 875 MHQTVKEL---SPKCNVSFLLSEDGSGKGAALITAV 907 M ++KEL +V S DGSG GAAL+ A Sbjct: 431 MESSLKELLGDEASGSVEVTHSNDGSGIGAALLAAS 466 Score = 492 bits (1266), Expect = e-139, Method: Composition-based stats. Identities = 159/461 (34%), Positives = 235/461 (50%), Gaps = 32/461 (6%) Query: 21 KIDKYLYAMR----LSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76 ++ L A L + EM GL+ D + +KML ++V ++P G E Sbjct: 14 RVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDG--GSKLKMLISYVDNLPSGDE 71 Query: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGD 136 KG F ALDLGG++FR++RV + ++ + V E E P +++ G +LF+ +AE L Sbjct: 72 KGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAK 131 Query: 137 FMEKRKIKDKKLP------VGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLN 190 F+ + +D LP +GFTF+FP +Q+ + LI WTK F G DVV LN Sbjct: 132 FV-ATECEDFHLPEGRQRELGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALN 190 Query: 191 KAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEG 250 KA+++ G D I A+VNDTVGT+ Y + +I+GTGTNA Y+E I G Sbjct: 191 KALERVG-LDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHG 249 Query: 251 ---DEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVR 307 G M IN EWG F S TEFD +D SLNPG+Q+ EK++SGMYLGE++R Sbjct: 250 LLPKSGEMVINMEWGNF---RSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILR 306 Query: 308 LILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKE-GLH----NAKEILTRLGVE 362 +L+KMA++ F + +L T +SA+ + L K+IL Sbjct: 307 RVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVP--T 364 Query: 363 PSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRD--NKGTPRLRTTVGVDGSLYKTH 420 S V +C I++ R A L AA + IL +L K ++ + +DG L++ + Sbjct: 365 TSLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHY 424 Query: 421 PQYSRRFHKTLRRLVPD---SDVRFLLSESGSGKGAAMVTA 458 Q+S +L+ L+ D V S GSG GAA++ A Sbjct: 425 TQFSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAA 465 >2YHX-A nrPDB Length = 457 Score = 210 bits (535), Expect = 2e-54, Method: Composition-based stats. Identities = 69/414 (16%), Positives = 150/414 (36%), Gaps = 28/414 (6%) Query: 509 VKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQ 568 + M+P +V + G + G FLA+ +GG + V+L+ + +G++ + ++ A + Sbjct: 44 IPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISL-AGRQESSIXASRSLAAAMSTTA 102 Query: 569 GTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDC 628 + + S + +PLGFTF + + G + F Sbjct: 103 IPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXL 162 Query: 629 VGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYME 688 +++ + +A + VA + D+ G + Y + ++G+I G+G NA Y Sbjct: 163 X--KLISAMXNAXFPAGDXXXS-VADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYWC 219 Query: 689 EMKNV-----EMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEK 743 + + G G M I + +F + Y ++ S A K + K Sbjct: 220 DSTXIGDAADGGXXGGAGXMXICCDQSSFR-KAFPSLPQIXYLXTLNXXSPXAXK-TFXK 277 Query: 744 MISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAI 803 G+ +R++L+ F G + + + T + ++I+ L+ Sbjct: 278 NSXAKNXGQSLRDVLMXFKXXGQX-HXXXAXSFXAANVENTSYPAKIQKLPHFDLRXXXD 336 Query: 804 LQ--QLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 861 L G+ +V+ +++ A +L + A+ K + G + Sbjct: 337 LFXGDQGIAXKTXMKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYSSG------HIAAX 390 Query: 862 GTLYKLHPHFSRIMHQTVKELS-------PKCNVSFLLSEDGSGKGAALITAVG 908 G+ + + FS + + + DG G + +I ++ Sbjct: 391 GSX-RSYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGXGAASXVIXSIA 443 Score = 122 bits (305), Expect = 9e-28, Method: Composition-based stats. Identities = 67/415 (16%), Positives = 142/415 (34%), Gaps = 30/415 (7%) Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120 + M+P +V G++ G F+A+ +GG ++ + + + ++ + Sbjct: 44 IPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISLAGRQESSIXASRSLAA--AMSTT 101 Query: 121 GSGSQLFDHVAEC-LGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASG 179 S L+ + A + +P+GFTF + + + + F + Sbjct: 102 AIPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAX 161 Query: 180 VEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYM 239 + ++ + A GD + VA + D+ G + Y D ++G+I G+G NA Y Sbjct: 162 L--XKLISAMXNAXFPAGDXXXS-VADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYW 218 Query: 240 EELRHI-----DLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFE 294 + I G G M I + +F + + ++ S K F Sbjct: 219 CDSTXIGDAADGGXXGGAGXMXICCDQSSFR-KAFPSLPQIXYLXTLNXXSPXAXK-TFX 276 Query: 295 KMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKE-GLHNAK 353 K G+ +R +L+ G NTS + I+K L Sbjct: 277 KNSXAKNXGQSLRDVLMXFKXXGQX-HXXXAXSFXAANVENTSYPAKIQKLPHFDLRXXX 335 Query: 354 EILT-RLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGV 412 ++ G+ V+ +++ + LV + AI + + G + Sbjct: 336 DLFXGDQGIAXKTXMKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYSSG------HIAA 389 Query: 413 DGSLYKTHPQYSRRFHKTLRRLVP-------DSDVRFLLSESGSGKGAAMVTAVA 460 GS +++ +S + + + G G + ++ ++A Sbjct: 390 XGSX-RSYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGXGAASXVIXSIA 443 >1HKG-A nrPDB Length = 457 Score = 202 bits (513), Expect = 7e-52, Method: Composition-based stats. Identities = 67/414 (16%), Positives = 148/414 (35%), Gaps = 28/414 (6%) Query: 509 VKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQ 568 + M+P +V + G++ G FLA+ +GG + V+L+ + +G + + ++ A + Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXL-AGYQESSIXASRSLAASMXTTA 102 Query: 569 GTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDC 628 + + S + +PLGFTF + + G + F Sbjct: 103 IPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXL 162 Query: 629 VGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYME 688 +++ + +A + VA + D+ G + Y + ++G+I G+G NA Y Sbjct: 163 X--KLISAMXNAXFPAGDX-XXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYWC 219 Query: 689 EMKNV-----EMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEK 743 + + G G M + +F + Y ++ S A K +EK Sbjct: 220 DSTXIADAADAGXXGGAGXMXVCCXQDSFR-KAFPSLPQIXYXXTLNXXSPXAXK-TFEK 277 Query: 744 MISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAI 803 G+ +R++L+ + G + + + + ++I+ L+ Sbjct: 278 NSXAKNXGQSLRDVLMXYKXXGQX-HXXXAXDFXAANVENSSYPAKIQKLPHFDLRXXXD 336 Query: 804 LQ--QLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 861 L G+ +V+ +++ A +L + A+ K + G + Sbjct: 337 LFXGDQGIAXKTXMKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYSSG------HIAAX 390 Query: 862 GTLYKLHPHFSRIMHQTVKELS-------PKCNVSFLLSEDGSGKGAALITAVG 908 G+ + + FS + + + DG G +I ++ Sbjct: 391 GSX-RDYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGEGAAXXVIXSIA 443 Score = 119 bits (299), Expect = 5e-27, Method: Composition-based stats. Identities = 67/415 (16%), Positives = 140/415 (33%), Gaps = 30/415 (7%) Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120 + M+P +V GS+ G F+A+ +GG ++ + + + ++ + Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAA--SMXTT 101 Query: 121 GSGSQLFDHVAEC-LGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASG 179 S L+ + A + +P+GFTF + + + + F + Sbjct: 102 AIPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAX 161 Query: 180 VEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYM 239 + ++ + A GD VA + D+ G + Y D ++G+I G+G NA Y Sbjct: 162 L--XKLISAMXNAXFPAGDX-XXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYW 218 Query: 240 EELRHI-----DLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFE 294 + I G G M + +F + + ++ S K FE Sbjct: 219 CDSTXIADAADAGXXGGAGXMXVCCXQDSFR-KAFPSLPQIXYXXTLNXXSPXAXK-TFE 276 Query: 295 KMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKE-GLHNAK 353 K G+ +R +L+ K + N+S + I+K L Sbjct: 277 KNSXAKNXGQSLRDVLMX-YKXXGQXHXXXAXDFXAANVENSSYPAKIQKLPHFDLRXXX 335 Query: 354 EILT-RLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGV 412 ++ G+ V+ +++ + LV + AI + + G + Sbjct: 336 DLFXGDQGIAXKTXMKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYSSG------HIAA 389 Query: 413 DGSLYKTHPQYSRRFHKTLRRLVP-------DSDVRFLLSESGSGKGAAMVTAVA 460 GS + + +S + + + G G ++ ++A Sbjct: 390 XGSX-RDYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGEGAAXXVIXSIA 443 >3ZR5-A nrPDB Length = 656 Score = 33.8 bits (76), Expect = 0.38, Method: Composition-based stats. Identities = 25/129 (19%), Positives = 45/129 (34%), Gaps = 4/129 (3%) Query: 50 GLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN--VHM 107 G+ AT ++L + P SE D++ G+S IL+V++ + Sbjct: 29 GIGAVSGGGATSRLLVNYPE--PYRSEILDYLFKPNFGASLHILKVEIGGDGQTTDGTEP 86 Query: 108 ESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAI 167 Y+ EN G L + D + +G FS+P ++ Sbjct: 87 SHMHYELDENYFRGYEWWLMKEAKKRNPDIILMGLPWSFPGWLGKGFSWPYVNLQLTAYY 146 Query: 168 LITWTKRFK 176 ++ W K Sbjct: 147 VVRWILGAK 155 >2BWY-A nrPDB Length = 440 Score = 32.3 bits (72), Expect = 1.1, Method: Composition-based stats. Identities = 23/111 (20%), Positives = 44/111 (39%), Gaps = 21/111 (18%) Query: 229 IIGTGTNACYMEELRH-IDLVEGDEGRMCINTEWGAFGDDGSLEDI---------RTEFD 278 I+G+G N C + + ++ +GD + E+ + D + R +D Sbjct: 232 IVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQREIYD 291 Query: 279 REID--RGSLN---PGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRI 324 ++ SL PG + E GE+VR+++ + K G+L Sbjct: 292 IVLESLETSLRLYRPGTSILE------VTGEVVRIMVSGLVKLGILKGDVD 336 >4NK4-A nrPDB Length = 301 Score = 31.5 bits (70), Expect = 2.0, Method: Composition-based stats. Identities = 16/80 (20%), Positives = 33/80 (41%), Gaps = 4/80 (5%) Query: 23 DKYLYAMRLSDETLIDIMTRFRKEM-KNGLSRDFNPTATVKMLPTFVRSIPDGS---EKG 78 D ++ M +S + +I+ R + M G +++++P + P S Sbjct: 145 DNFIQTMLVSCFSFTEIVRRAAQLMPHGGAMITLTYGGSMRVVPNYNAMAPAKSALESST 204 Query: 79 DFIALDLGGSSFRILRVQVN 98 ++A D GG + RI + Sbjct: 205 KYLACDYGGMNIRINAISAG 224 >1G8W-A nrPDB Length = 233 Score = 30.4 bits (67), Expect = 3.8, Method: Composition-based stats. Identities = 30/134 (22%), Positives = 49/134 (36%), Gaps = 18/134 (13%) Query: 71 IPDGSE---KGDFIAL-DLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQL 126 +P GS+ KG F+ L D S+F + V+ + N++ N + + Sbjct: 93 VPVGSQPKDKGGFLGLFDGSNSNFHTVAVEFDTLYNKDWDPTERHIGIDVNSIRSIKTTR 152 Query: 127 FDHV----AECLGDFMEKRKIKDKKL--PVGFTFSFPCQQSKIDEAILITW-------TK 173 +D V AE L + + L P T SF + +++L W T Sbjct: 153 WDFVNGENAEVLITYDSSTNLLVASLVYPSQKT-SFIVSDTVDLKSVLPEWVSVGFSATT 211 Query: 174 RFKASGVEGADVVK 187 VE DV+ Sbjct: 212 GINKGNVETNDVLS 225 >5ZI1-A nrPDB Length = 609 Score = 30.4 bits (67), Expect = 4.0, Method: Composition-based stats. Identities = 8/42 (19%), Positives = 20/42 (47%) Query: 399 DNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 440 +G +L+ GV G +++ + ++ R + L+P + Sbjct: 194 YKEGLNKLKNASGVKGKVWENYNRFRREMTIMVLDLLPLFPI 235 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.315 0.140 0.372 Lambda K H 0.267 0.0428 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 34,709,724 Number of Sequences: 36641 Number of extensions: 1480429 Number of successful extensions: 4118 Number of sequences better than 10.0: 20 Number of HSP's better than 10.0 without gapping: 30 Number of HSP's successfully gapped in prelim test: 16 Number of HSP's that attempted gapping in prelim test: 3850 Number of HSP's gapped (non-prelim): 78 length of query: 917 length of database: 10,336,785 effective HSP length: 106 effective length of query: 811 effective length of database: 6,452,839 effective search space: 5233252429 effective search space used: 5233252429 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 64 (29.2 bits)