BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P19099 (503 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4ZGX-A nrPDB 984 0.0 6M7X-A nrPDB 872 0.0 3N9Z-A nrPDB 352 3e-97 3MZS-A nrPDB 351 4e-97 3K9V-A nrPDB 215 4e-56 5VEU-A nrPDB 101 9e-22 6DA2-A nrPDB 95 8e-20 4R1Z-A nrPDB 94 1e-19 6B82-A nrPDB 92 6e-19 5YLW-A nrPDB 91 9e-19 3DL9-A nrPDB 84 1e-16 6C94-A nrPDB 82 5e-16 2PG7-A nrPDB 82 7e-16 5VBU-A nrPDB 80 2e-15 2VE3-A nrPDB 80 2e-15 5W0C-A nrPDB 78 9e-15 4R20-A nrPDB 77 1e-14 3E6I-A nrPDB 74 1e-13 4GQS-A nrPDB 73 3e-13 2NNH-A nrPDB 73 3e-13 1N6B-A nrPDB 72 4e-13 3MDV-A nrPDB 71 1e-12 3TBG-A nrPDB 71 1e-12 3QZ1-A nrPDB 70 1e-12 5FOI-A nrPDB 70 3e-12 5UYS-A nrPDB 69 6e-12 6IQ5-A nrPDB 65 8e-11 3S79-A nrPDB 64 1e-10 6DWN-A nrPDB 64 2e-10 3IBD-A nrPDB 62 7e-10 4H1N-A nrPDB 61 1e-09 6AYB-A nrPDB 60 2e-09 2RFC-A nrPDB 60 2e-09 4WMZ-A nrPDB 60 2e-09 6GMF-A nrPDB 60 3e-09 5E0E-A nrPDB 60 3e-09 4KPA-A nrPDB 59 4e-09 2ZBZ-A nrPDB 59 5e-09 1WIY-A nrPDB 59 7e-09 4UBS-A nrPDB 58 8e-09 2HI4-A nrPDB 58 8e-09 3MGX-A nrPDB 58 8e-09 6HQG-A nrPDB 58 1e-08 5E58-A nrPDB 57 2e-08 6B11-A nrPDB 57 2e-08 5VWS-A nrPDB 56 3e-08 5JLC-A nrPDB 55 9e-08 3SN5-A nrPDB 55 1e-07 3RWL-A nrPDB 54 1e-07 3JUS-A nrPDB 54 1e-07 6F0B-A nrPDB 54 2e-07 3TYW-A nrPDB 53 2e-07 2W0A-A nrPDB 53 3e-07 5FYF-A nrPDB 53 3e-07 5IT1-A nrPDB 52 4e-07 3ABB-A nrPDB 52 6e-07 2X2N-A nrPDB 52 7e-07 2XKR-A nrPDB 51 1e-06 6HQW-A nrPDB 50 2e-06 1UE8-A nrPDB 50 2e-06 4RM4-A nrPDB 50 2e-06 5YHJ-A nrPDB 50 2e-06 2WX2-A nrPDB 50 3e-06 2WIO-A nrPDB 50 3e-06 5OFQ-A nrPDB 49 4e-06 3EL3-A nrPDB 49 4e-06 3ABA-A nrPDB 49 4e-06 3R9C-A nrPDB 49 6e-06 3TKT-A nrPDB 49 6e-06 5YSW-A nrPDB 48 1e-05 3A1L-A nrPDB 48 1e-05 3A50-A nrPDB 47 1e-05 1UED-A nrPDB 47 1e-05 5LIE-A nrPDB 47 1e-05 5DE9-A nrPDB 47 2e-05 4WPZ-A nrPDB 47 2e-05 6HQD-A nrPDB 47 2e-05 4TRI-A nrPDB 47 2e-05 3NC3-A nrPDB 46 3e-05 4PWV-A nrPDB 46 3e-05 6GII-A nrPDB 46 3e-05 5L94-A nrPDB 46 5e-05 2Z36-A nrPDB 46 5e-05 3OFT-A nrPDB 45 5e-05 3L4D-A nrPDB 45 6e-05 5LIV-A nrPDB 45 7e-05 6F88-A nrPDB 45 8e-05 5D3U-A nrPDB 45 8e-05 2FR7-A nrPDB 45 8e-05 6CR2-A nrPDB 45 8e-05 4YZR-A nrPDB 45 9e-05 5FSA-A nrPDB 45 1e-04 2IAG-A nrPDB 44 1e-04 1CPT-A nrPDB 44 2e-04 6G5O-A nrPDB 43 2e-04 5XJN-A nrPDB 43 3e-04 5H1Z-A nrPDB 43 3e-04 5GWE-A nrPDB 43 3e-04 5M0P-A nrPDB 42 5e-04 5XW2-A nrPDB 42 5e-04 6CVC-A nrPDB 42 6e-04 2ZQJ-A nrPDB 42 6e-04 6FYJ-A nrPDB 42 6e-04 2Y5N-A nrPDB 42 6e-04 5HDI-A nrPDB 42 7e-04 5HIW-A nrPDB 42 8e-04 2VZM-A nrPDB 42 8e-04 6GK6-A nrPDB 42 8e-04 3EJB-B nrPDB 42 8e-04 4MM0-A nrPDB 41 0.001 6G71-A nrPDB 41 0.001 4OQR-A nrPDB 40 0.002 1Z8P-A nrPDB 40 0.002 1F4U-A nrPDB 40 0.002 5HH3-A nrPDB 40 0.002 4OQS-A nrPDB 40 0.002 4Z5P-A nrPDB 40 0.002 4DO1-A nrPDB 39 0.004 4YT3-A nrPDB 39 0.004 1Q5D-A nrPDB 39 0.004 2WM5-A nrPDB 39 0.005 4XE3-A nrPDB 39 0.005 3WVS-A nrPDB 39 0.005 5Y1I-A nrPDB 39 0.006 1LG9-A nrPDB 39 0.007 5CJE-A nrPDB 39 0.007 3AWQ-A nrPDB 38 0.008 5EX6-C nrPDB 38 0.009 5NWS-A nrPDB 37 0.014 3B98-A nrPDB 37 0.014 3NV6-A nrPDB 37 0.014 3P3Z-A nrPDB 37 0.014 1GWI-A nrPDB 37 0.021 5L1U-A nrPDB 36 0.046 6FSH-A nrPDB 35 0.052 6DCD-A nrPDB 35 0.053 2WIY-A nrPDB 35 0.068 1EHE-A nrPDB 35 0.070 2NZA-A nrPDB 35 0.088 5XNT-A nrPDB 35 0.092 6A7J-A nrPDB 34 0.18 2UUQ-A nrPDB 34 0.19 5OQL-R nrPDB 33 0.20 5EX8-A nrPDB 33 0.22 4JBT-A nrPDB 33 0.36 5OMS-A nrPDB 32 0.52 5ZR1-C nrPDB 32 0.63 5DQN-A nrPDB 32 0.92 4FB2-A nrPDB 31 0.96 2X9P-A nrPDB 31 1.4 6A7I-A nrPDB 31 1.5 4TX3-A nrPDB 31 1.6 3BUJ-A nrPDB 30 2.9 4Z5Q-A nrPDB 30 3.4 6M7L-A nrPDB 30 3.5 4NQ1-A nrPDB 29 4.0 2QBO-A nrPDB 29 5.2 3PS7-A nrPDB 29 5.6 5KYO-A nrPDB 28 6.7 1XDN-A nrPDB 28 6.8 >4ZGX-A nrPDB Length = 489 Score = 984 bits (2544), Expect = 0.0, Method: Compositional matrix adjust. Identities = 477/480 (99%), Positives = 479/480 (99%) Query: 24 LGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL 83 + T+AARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL Sbjct: 1 MATKAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL 60 Query: 84 GGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 143 GGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR Sbjct: 61 GGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 120 Query: 144 LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203 LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA Sbjct: 121 LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 180 Query: 204 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCI 263 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCI Sbjct: 181 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCI 240 Query: 264 FQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPL 323 FQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPL Sbjct: 241 FQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPL 300 Query: 324 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE Sbjct: 301 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 360 Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF Sbjct: 361 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 420 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 503 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN Sbjct: 421 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 480 >6M7X-A nrPDB Length = 484 Score = 872 bits (2254), Expect = 0.0, Method: Compositional matrix adjust. Identities = 442/480 (92%), Positives = 454/480 (94%) Query: 24 LGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL 83 + + + PRTVLPFEAMP+ PGNRWLRLLQIWREQGYE LHLE+HQTFQELGPIFRY+L Sbjct: 1 MAKKTSSVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 60 Query: 84 GGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 143 GG MVCVMLPEDVEKLQQVDSLHP RM LEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR Sbjct: 61 GGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 120 Query: 144 LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203 LNP+VLSP AVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA Sbjct: 121 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 180 Query: 204 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCI 263 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRW SPKVWKEHFEAWDCI Sbjct: 181 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCI 240 Query: 264 FQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPL 323 FQYGDNCIQKIYQELAF+RPQ YT IVAELLL AELS +AIKANSMELTAGSVDTT FPL Sbjct: 241 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL 300 Query: 324 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 LMTLFELARNP+VQQ LRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE Sbjct: 301 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 360 Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 RV SSDLVLQNYHIPAGTLV+VFLYSLGRN ALFPRPERYNPQRWLDIRGSGRNF+HVPF Sbjct: 361 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 420 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 503 GFGMRQCLGRRLAEAEMLLLLHHVLKH VETLTQEDIKMVYSFILRP PLLTFRAIN Sbjct: 421 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 480 >3N9Z-A nrPDB Length = 487 Score = 352 bits (902), Expect = 3e-97, Method: Compositional matrix adjust. Identities = 188/478 (39%), Positives = 274/478 (57%), Gaps = 5/478 (1%) Query: 28 AARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPR 87 + R+PR PF +P N WL L WRE G +HL Q FQ+ GPI+R LG Sbjct: 1 STRSPR---PFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVE 57 Query: 88 MVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPD 147 V V+ PEDV L + + +P R ++ PWVAY Q+ GV L W+ +R+ LN + Sbjct: 58 SVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQE 117 Query: 148 VLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 V++P+A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ +FGE Sbjct: 118 VMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGE 177 Query: 208 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYG 267 R G++ + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF Sbjct: 178 RQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKA 237 Query: 268 DNCIQKIYQELAFNRPQH--YTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLM 325 D Q Y EL H Y GI+ LL +++S E IKAN E+ AG VDTT+ L Sbjct: 238 DIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQW 297 Query: 326 TLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERV 385 L+E+ARN VQ +LR E LAA +PLL+A++KETLRL+P+ + L+R Sbjct: 298 HLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRY 357 Query: 386 VSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGF 445 + +DLVL++Y IPA TLVQV +Y+LGR F PE ++P RWL + F ++ FG+ Sbjct: 358 LVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGW 417 Query: 446 GMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 503 G+RQCLGRR+AE EM + L ++L++F VE D+ ++ IL P TF N Sbjct: 418 GVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFN 475 >3MZS-A nrPDB Length = 486 Score = 351 bits (901), Expect = 4e-97, Method: Compositional matrix adjust. Identities = 177/477 (37%), Positives = 282/477 (59%), Gaps = 4/477 (0%) Query: 28 AARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPR 87 + + PR P+ +P N WL L WRE+G + +H + FQ+ GPI+R LG Sbjct: 3 STKTPR---PYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLE 59 Query: 88 MVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPD 147 V ++ PEDV L + + +P R + PW+AY ++ GV W+ +R+ LN + Sbjct: 60 SVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTE 119 Query: 148 VLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 V++P+A++ F+P+++ V++DF L K++ Q G D++ +FH+ E+ +FGE Sbjct: 120 VMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGE 179 Query: 208 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYG 267 RLG++ + + + F+ A+ MF ++V L+ +P L R K W++H AWD IF Sbjct: 180 RLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKA 239 Query: 268 DNCIQKIYQELAFNRP-QHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMT 326 + + YQ+L ++Y GI+ LL ++ LE +KAN E+ AG V+TT+ L Sbjct: 240 EKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWH 299 Query: 327 LFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVV 386 L+E+AR+ +VQ++LR+E L A K +PLL+A++KETLRL+P+ + L+R Sbjct: 300 LYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYP 359 Query: 387 SSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFG 446 SDLVLQ+Y IPA TLVQV +Y++GR+ A F P++++P RWL +F ++ FG+G Sbjct: 360 ESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWG 419 Query: 447 MRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 503 +RQC+GRR+AE EM L L H+L++F VE D+ +++ IL P L FR N Sbjct: 420 VRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFN 476 >3K9V-A nrPDB Length = 482 Score = 215 bits (548), Expect = 4e-56, Method: Compositional matrix adjust. Identities = 134/454 (29%), Positives = 225/454 (49%), Gaps = 16/454 (3%) Query: 52 LLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRM 111 LL+I+ + G + H + + ++ G IFR LG V + P +E L + +S HP R+ Sbjct: 38 LLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRL 97 Query: 112 ILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQA 171 ++PW AYR HR G+ +L G EW+ R ++ P + + ++ V DF + Sbjct: 98 EIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLER 157 Query: 172 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 231 + + L + RG + D+ + ++ E+ L L+ +R GL+ +L F+ A++ M Sbjct: 158 MDE--LCDERGRIP-DLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMM 214 Query: 232 KSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYT---- 287 + ++M P L + ++ KVW+ H AWD IF+ CI NR Q Y+ Sbjct: 215 STFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCID--------NRLQRYSQQPG 266 Query: 288 -GIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLA 346 + ++ + LS + + A EL +V+TTA L+ L+ L+RNP Q+ L QE + Sbjct: 267 ADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQS 326 Query: 347 AAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVF 406 + +P L+A LKE++RL P F R + VL Y +P GT++ + Sbjct: 327 VLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLN 386 Query: 407 LYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHH 466 LG + F ++ P+RWL F H+PFG G R C+GRRLAE ++ L L Sbjct: 387 TQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCW 446 Query: 467 VLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFR 500 +++ + + E ++M++ IL P + FR Sbjct: 447 IIQKYDIVATDNEPVEMLHLGILVPSRELPIAFR 480 >5VEU-A nrPDB Length = 480 Score = 101 bits (251), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 98/369 (26%), Positives = 169/369 (45%), Gaps = 44/369 (11%) Query: 126 KCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMV----DAVARDFSQALKKK---VLQ 178 K + L EW+ R L+P S K + F P++ D + R+ + +K L+ Sbjct: 94 KSAISLAEDEEWKRIRSLLSPTFTSGKLKEMF-PIIAQYGDVLVRNLRREAEKGKPVTLK 152 Query: 179 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFK-STVQL 237 + G+ ++DV + G G+ S ++ F+ + + K + Sbjct: 153 DIFGAYSMDV---------------ITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDP 197 Query: 238 MFMPRSLSRWISPKVWKEHFEAWDCIFQYGD--NCIQKIYQELA---FNRPQHYTGIVAE 292 +F+ L +++P FEA + D N + K + N Q + + Sbjct: 198 LFLSIILFPFLTPV-----FEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQ 252 Query: 293 LLLKAELS--LEAIKA-NSMELTAGSV-------DTTAFPLLMTLFELARNPDVQQILRQ 342 L++ ++ S E+ KA + +EL A S+ +TT+ L TL+ELA +PDVQQ L++ Sbjct: 253 LMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQK 312 Query: 343 ESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTL 402 E A + + A ++ L + ETLRL+PV + LER D+ + IP G++ Sbjct: 313 EIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSM 372 Query: 403 VQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLL 462 V + Y+L + + PE + P+R+ + S + + PFG G R C+G R A M L Sbjct: 373 VVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKL 432 Query: 463 LLHHVLKHF 471 L VL++F Sbjct: 433 ALIRVLQNF 441 >6DA2-A nrPDB Length = 487 Score = 94.7 bits (234), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 63/199 (31%), Positives = 104/199 (52%), Gaps = 4/199 (2%) Query: 296 KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHP 355 KA LE + + + + AG +TT+ L ++ELA +PDVQQ L++E A + + Sbjct: 268 KALSDLELVAQSIIFIFAG-YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT 326 Query: 356 QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAA 415 ++ L + ETLRL+P+ + LERV D+ + IP G +V + Y+L R+ Sbjct: 327 YDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPK 386 Query: 416 LFPRPERYNPQRWLDIRGSGRN-FHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVE 474 + PE++ P+R+ + + + PFG G R C+G R A M L L VL++F + Sbjct: 387 YWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 446 Query: 475 TL--TQEDIKMVYSFILRP 491 TQ +K+ +L+P Sbjct: 447 PCKETQIPLKLSLGGLLQP 465 >4R1Z-A nrPDB Length = 439 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 73/246 (29%), Positives = 121/246 (49%), Gaps = 23/246 (9%) Query: 268 DNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSME---------LTAGS--- 315 D +QK Y+E + + + LL+A+ S E +++ + +T G Sbjct: 173 DKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFG 232 Query: 316 --VDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKAT-TELPLLRAALKET 372 V+TT L ++ L NP VQ+ + QE L + HPQ + LP L A ++E Sbjct: 233 AGVETTTTVLKWSIAYLVHNPQVQRKI-QEELDSKIGKERHPQLSDRGNLPYLEATIREV 291 Query: 373 LRLYPVG-LFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDI 431 LR+ PV L + V D + Y + GT V + L+SL + + PE ++P R+L+ Sbjct: 292 LRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNE 351 Query: 432 RGSGR---NFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQE---DIKMVY 485 G G + ++PFG G+R CLG LA+ E+ L L +L+ F +E T + D++ + Sbjct: 352 EGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKF 411 Query: 486 SFILRP 491 +L+P Sbjct: 412 GVVLQP 417 >6B82-A nrPDB Length = 509 Score = 92.0 bits (227), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 70/246 (28%), Positives = 118/246 (47%), Gaps = 23/246 (9%) Query: 268 DNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSM--------------ELTA 313 D +QK Y+E + + + LL+A+ S E +++ E+ Sbjct: 237 DKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFG 296 Query: 314 GSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKAT-TELPLLRAALKET 372 V+TT L ++ L NP VQ+ + QE L + HPQ + LP L A + E Sbjct: 297 AGVETTTTTLKWSIAYLVHNPQVQRKI-QEELDSKIGKERHPQLSDRGNLPYLEATICEV 355 Query: 373 LRLYPVG-LFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDI 431 +R+ PV L + V D + Y + GT V + ++SL + + PE ++P R+L+ Sbjct: 356 MRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNE 415 Query: 432 RGSGR---NFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQE---DIKMVY 485 G G + ++PFG G+R CLG LA+ E+ L L +L+ F +E T + D++ + Sbjct: 416 EGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKF 475 Query: 486 SFILRP 491 +L+P Sbjct: 476 GVVLQP 481 >5YLW-A nrPDB Length = 495 Score = 91.3 bits (225), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 52/151 (34%), Positives = 82/151 (54%), Gaps = 3/151 (1%) Query: 309 MELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAA 368 ++L G DT + + EL NPD L+ E + A + A +LP L+A Sbjct: 293 LDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAMPKLPYLQAV 352 Query: 369 LKETLRLYPVG-LFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 +KE +R++P G L L R SD + Y IP GT + + Y++GR+ +++ PE ++P+R Sbjct: 353 IKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTDPETFDPER 412 Query: 428 WLD--IRGSGRNFHHVPFGFGMRQCLGRRLA 456 +LD I G+++ +PFG G R C G LA Sbjct: 413 FLDNKIDFKGQDYELLPFGSGRRVCPGMPLA 443 >3DL9-A nrPDB Length = 479 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 78/304 (25%), Positives = 129/304 (42%), Gaps = 29/304 (9%) Query: 186 LDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQL-----MFM 240 D + I + +NL +FGER + +F H +E +F V+L +F+ Sbjct: 151 FDFKQLITNAVSNITNLIIFGERF-------TYEDTDFQHMIE-LFSENVELAASASVFL 202 Query: 241 PRSLSRWISPKVWKEH---FEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKA 297 + WI + +H F ++ + I+K PQH+ + + + Sbjct: 203 YNAFP-WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQG 261 Query: 298 E------LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASI 351 + S E + + EL +TT L + +A P++Q +++E Sbjct: 262 KNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPN 321 Query: 352 SEHPQKATTELPLLRAALKETLR---LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLY 408 + ++P A L E LR + P+G+F S D V++ Y IP GT V LY Sbjct: 322 GKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIF--HATSEDAVVRGYSIPKGTTVITNLY 379 Query: 409 SLGRNAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHV 467 S+ + + PE ++P+R+LD G + VPF G R CLG LA EM L + Sbjct: 380 SVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTAL 439 Query: 468 LKHF 471 L+ F Sbjct: 440 LQRF 443 >6C94-A nrPDB Length = 497 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 78/349 (22%), Positives = 148/349 (42%), Gaps = 26/349 (7%) Query: 128 GVFLLNGPEWRFNRLRLNP----DVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGS 183 G+ +L+GP+W +R L P DVL P A+ D ++ + +K + A Sbjct: 103 GLLVLDGPKWFQHRKLLTPGFHYDVLKPYV---------AIFADSTRIMLEKWEKKACEG 153 Query: 184 LTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS 243 + D+ + H ++ FG+ + H SS + + L ++ + + Sbjct: 154 KSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVA-VSELTLLMQQRIDSFQYHND 212 Query: 244 LSRWISP------KVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKA 297 W++P + + + D + + +Q + +H + L ++ Sbjct: 213 FIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAALQDEKEREKIQNRRHLDFLDILLDVRG 272 Query: 298 E----LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISE 353 E LS ++A DTT + L+ +A P+ QQ R+E Sbjct: 273 ESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEVREILGDQDS 332 Query: 354 HPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDL-VLQNYHIPAGTLVQVFLYSLGR 412 + ++ L +KE RLYP + R +S + + +PAG+L+ + +Y+L R Sbjct: 333 FQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSLISLHIYALHR 392 Query: 413 NAALFPRPERYNPQRWLDIRGSGRN-FHHVPFGFGMRQCLGRRLAEAEM 460 N+ ++P PE ++P R+ SGR+ + +PF G R C+G++ A EM Sbjct: 393 NSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRNCIGQQFAMNEM 441 >2PG7-A nrPDB Length = 476 Score = 81.6 bits (200), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 102/464 (21%), Positives = 192/464 (41%), Gaps = 50/464 (10%) Query: 45 PGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVD 104 PG L + + + E ++ + + + GP+F +LG PR V V+ D + VD Sbjct: 13 PGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLG-PRRVVVLCGHDAVREALVD 71 Query: 105 SLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAV 164 E +G+ GV NG K ++RF A Sbjct: 72 QAEEFSGRGEQATFDWVFKGY--GVVFSNGERA--------------KQLRRF---SIAT 112 Query: 165 ARDFS---QALKKKVLQNA-------RGSLTLDVQPSIFHYTIEASNLA---LFGERLGL 211 RDF + +++++ + A RG+ ++ P+ F + SN+ +FG+R Sbjct: 113 LRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFF-LSRTVSNVISSIVFGDRFDY 171 Query: 212 VGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCI 271 S L + ST QL M S+ + + P ++ F+ + + + Sbjct: 172 KDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHL-PGPQQQAFQLLQGLEDFIAKKV 230 Query: 272 QKIYQELAFNRPQHYTGIVAELLLK---------AELSLEAIKANSMELTAGSVDTTAFP 322 + + L N P+ + + L++ E L+ + +++L G +T + Sbjct: 231 EHNQRTLDPNSPRDF---IDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTT 287 Query: 323 LLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPV-GLF 381 L L ++P+V+ + +E + + ++P + A + E R V + Sbjct: 288 LRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMS 347 Query: 382 LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS-GRNFHH 440 L R V D +++ +P GT V L S+ R+ + F P+ +NPQ +L+ +G ++ Sbjct: 348 LARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAF 407 Query: 441 VPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF-LVETLTQEDIKM 483 VPF G R C G LA E+ L V+++F L + + +DI + Sbjct: 408 VPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDV 451 >5VBU-A nrPDB Length = 476 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 57/168 (33%), Positives = 85/168 (50%), Gaps = 7/168 (4%) Query: 308 SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE---SLAAAASISEHPQKATTELPL 364 +++L G +TTA L + L +P++QQ L++E L AS S P K LPL Sbjct: 267 AVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPL 326 Query: 365 LRAALKETLRLYPV-GLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERY 423 L A + E LRL PV L L + + Y IP GT++ L + ++ RP + Sbjct: 327 LNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 386 Query: 424 NPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 P R+L+ G+N + FG G R CLG LA E+ ++L +L+ F Sbjct: 387 WPDRFLE---PGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAF 431 >2VE3-A nrPDB Length = 444 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 58/196 (29%), Positives = 95/196 (48%), Gaps = 5/196 (2%) Query: 299 LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKA 358 LSL +K + L +T L L ++ D+++ +RQE S E + Sbjct: 239 LSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLS-QELTAET 297 Query: 359 TTELPLLRAALKETLRLYP-VGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALF 417 ++P L L+E LRL P VG ++ D Q +H P G LV + + L+ Sbjct: 298 LKKMPYLDQVLQEVLRLIPPVGGGFRELIQ-DCQFQGFHFPKGWLVSYQISQTHADPDLY 356 Query: 418 PRPERYNPQRWLDIRGSGRN--FHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVET 475 P PE+++P+R+ + N F HVPFG G+R+CLG+ A EM L +++ F Sbjct: 357 PDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFDWTL 416 Query: 476 LTQEDIKMVYSFILRP 491 L +++++V + RP Sbjct: 417 LPGQNLELVVTPSPRP 432 >5W0C-A nrPDB Length = 477 Score = 78.2 bits (191), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 87/388 (22%), Positives = 161/388 (41%), Gaps = 52/388 (13%) Query: 117 VAYRQHRGHKCGVFLLNGPEW----RFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQAL 172 +A R +RG G+ NG +W RF+ + L + ++++ V AR + L Sbjct: 85 LAERANRGF--GIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIED---RVQEEARCLVEEL 139 Query: 173 KKKVLQNARGSLTLDVQPS------IFHYTIEASN------LALFGERLGLVGHSPSSAS 220 +K + L P IFH + + + E + ++ Sbjct: 140 RKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQIC 199 Query: 221 LNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF 280 NF ++ + +L+ + +I KV KEH E+ D Sbjct: 200 NNFSPIIDYFPGTHNKLLKNVAFMKSYILEKV-KEHQESMD------------------M 240 Query: 281 NRPQHYTGIVAELLLK------AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNP 334 N PQ + + K +E ++E+++ +++L +TT+ L L L ++P Sbjct: 241 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 300 Query: 335 DVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLR---LYPVGLFLERVVSSDLV 391 +V +++E + + +P A + E R L P L V+ D+ Sbjct: 301 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSL--PHAVTCDIK 358 Query: 392 LQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQC 450 +NY IP GT + + L S+ + FP PE ++P +LD G+ ++ + +PF G R C Sbjct: 359 FRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRIC 418 Query: 451 LGRRLAEAEMLLLLHHVLKHFLVETLTQ 478 +G LA E+ L L +L++F +++L Sbjct: 419 VGEALAGMELFLFLTSILQNFNLKSLVD 446 >4R20-A nrPDB Length = 486 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 101/200 (50%), Gaps = 7/200 (3%) Query: 298 ELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQK 357 +++ + + + E V+TT+ LL T+ L +P +Q+ ++ E L + P Sbjct: 271 DITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAE-LDECVGVDRPPCL 329 Query: 358 AT-TELPLLRAALKETLRLYPVG-LFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAA 415 + LPLL A L E +R+ PV + + V D L + +P GT V V ++++ + Sbjct: 330 SDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPK 389 Query: 416 LFPRPERYNPQRWLDIRGSGRN-FHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVE 474 + +PE++NP+R+L+ G + +PFG G R C+G LA E+ L + L+ F Sbjct: 390 HWDQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFS 449 Query: 475 TLTQE---DIKMVYSFILRP 491 ++ D++ + +L+P Sbjct: 450 CPSEASLPDLQGRFGVVLQP 469 >3E6I-A nrPDB Length = 476 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 107/432 (24%), Positives = 172/432 (39%), Gaps = 43/432 (9%) Query: 73 QELGPIFRYNLGGPRMVCVMLPEDV-EKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFL 131 Q GP+F +G RMV + + V E L R L + A+R G+ Sbjct: 41 QRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDR-----GIIF 95 Query: 132 LNGPEWR-FNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQP 190 NGP W+ R L Q + A +AL+K Q + + P Sbjct: 96 NNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAP 155 Query: 191 SI----------FHYTIEA--SNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM 238 F Y E + LF E L+ NF L + S +++ Sbjct: 156 CNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVI 215 Query: 239 FMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQEL--AFNRPQHYTGIVAELLLK 296 + ++S +V KEH ++ D NC + + L + +H AE L Sbjct: 216 KNVAEVKEYVSERV-KEHHQSLD------PNCPRDLTDCLLVEMEKEKH----SAERLY- 263 Query: 297 AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ 356 +++ I +L +TT+ L L L + P++++ L +E Sbjct: 264 ---TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAI 320 Query: 357 KATTELPLLRAALKETLR---LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRN 413 K E+P + A + E R L P L E + D + + Y IP GT+V L S+ + Sbjct: 321 KDRQEMPYMDAVVHEIQRFITLVPSNLPHE--ATRDTIFRGYLIPKGTVVVPTLDSVLYD 378 Query: 414 AALFPRPERYNPQRWLDIRGSGR-NFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFL 472 FP PE++ P+ +L+ G + + + PF G R C G LA E+ LLL +L+HF Sbjct: 379 NQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFN 438 Query: 473 VETLTQ-EDIKM 483 ++ L +DI + Sbjct: 439 LKPLVDPKDIDL 450 >4GQS-A nrPDB Length = 477 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 50/185 (27%), Positives = 91/185 (49%), Gaps = 6/185 (3%) Query: 296 KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHP 355 ++E ++E + + +L +TT+ L L L ++P+V +++E Sbjct: 262 QSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPC 321 Query: 356 QKATTELPLLRAALKETLR---LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGR 412 + +P A + E R L P L V+ D+ +NY IP GT + L S+ Sbjct: 322 MQDRGHMPYTDAVVHEVQRYIDLIPTSL--PHAVTCDVKFRNYLIPKGTTILTSLTSVLH 379 Query: 413 NAALFPRPERYNPQRWLDIRGSGRNFHH-VPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 + FP PE ++P+ +LD G+ + ++ +PF G R C+G LA E+ L L +L++F Sbjct: 380 DNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF 439 Query: 472 LVETL 476 +++L Sbjct: 440 NLKSL 444 >2NNH-A nrPDB Length = 476 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 97/201 (48%), Gaps = 8/201 (3%) Query: 296 KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHP 355 K+E ++E + +L +TT+ L L L ++P+V +++E Sbjct: 261 KSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC 320 Query: 356 QKATTELPLLRAALKETLR---LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGR 412 + + +P A + E R L P G+ V++D +NY IP GT + L S+ Sbjct: 321 MQDRSHMPYTDAVVHEIQRYSDLVPTGV--PHAVTTDTKFRNYLIPKGTTIMALLTSVLH 378 Query: 413 NAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 + FP P ++P +LD G+ ++ + +PF G R C G LA E+ L L +L++F Sbjct: 379 DDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNF 438 Query: 472 LVETLTQEDIKMVYSFILRPG 492 ++++ +D+K + + + G Sbjct: 439 NLKSV--DDLKNLNTTAVTKG 457 >1N6B-A nrPDB Length = 473 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 59/236 (25%), Positives = 109/236 (46%), Gaps = 9/236 (3%) Query: 250 PKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTG---IVAELLLKAELSLEAIKA 306 P + K + D I + +++ + L N P+ + I E E +LE++ Sbjct: 209 PGIHKTLLKNADYIKNFIMEKVKEHQKLLDVNNPRDFIDCFLIKMEQENNLEFTLESLVI 268 Query: 307 NSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLR 366 +L +TT+ L +L L ++P+V +++E + + +P Sbjct: 269 AVSDLFGAGTETTSTTLRYSLLLLLKHPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTD 328 Query: 367 AALKETLR---LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERY 423 A + E R L P L V+ D+ +NY IP GT + L S+ + FP P+ + Sbjct: 329 AVIHEIQRFIDLLPTNL--PHAVTRDVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVF 386 Query: 424 NPQRWLDIRGS-GRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQ 478 +P +LD G+ ++ + +PF G R C+G LA E+ L L +L++F +++L + Sbjct: 387 DPGHFLDESGNFKKSDYFMPFSAGKRMCVGEGLARMELFLFLTSILQNFKLQSLVE 442 >3MDV-A nrPDB Length = 456 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 98/438 (22%), Positives = 173/438 (39%), Gaps = 29/438 (6%) Query: 73 QELGPIFRYNLGGPRMVCVMLPEDVEK-LQQVDSLHPCRMILEPWVAYRQHRGHKCGVFL 131 ++ GP+ R N+ V V PE V+K L +M + + + V Sbjct: 21 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSE 80 Query: 132 LNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPS 191 N W R R+ S ++ + + A + L+ K A G + +Q Sbjct: 81 CNYERWHKQR-RVIDLAFSRSSLVSLMETFNEKAEQLVEILEAK----ADGQTPVSMQDM 135 Query: 192 IFHYTIEASNLALFGERLGLV--GHSPSSASLNFLHALEVMFKSTVQLM-FMPRSLSRWI 248 + + ++ A FG ++ P S ++ + LE + S L F+P Sbjct: 136 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLM--LEGITASRNTLAKFLPGK----- 188 Query: 249 SPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSL---EAIK 305 K +E E+ + Q G + +Q+ + A R + + +LKAE E + Sbjct: 189 -RKQLREVRESIRFLRQVGRDWVQRRRE--ALKRGEEVPADILTQILKAEEGAQDDEGLL 245 Query: 306 ANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLL 365 N + +T+A L T+ EL+R P++ L+ E S + L L Sbjct: 246 DNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYL 305 Query: 366 RAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNP 425 LKE+LRLYP R++ + ++ +P T + Y +GR F P +NP Sbjct: 306 SQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNP 365 Query: 426 QRWLDIRGSGR---NFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIK 482 R+ G G F + PF G R C+G++ A+ E+ +++ +L+ + + Sbjct: 366 DRF----GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFG 421 Query: 483 MVYSFILRPGTSPLLTFR 500 + L+P L T R Sbjct: 422 LQEQATLKPLDPVLCTLR 439 >3TBG-A nrPDB Length = 479 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 52/203 (25%), Positives = 98/203 (48%), Gaps = 9/203 (4%) Query: 296 KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHP 355 ++ + E ++ +L + + TT+ L L + +PDVQ+ ++QE + Sbjct: 265 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPE 324 Query: 356 QKATTELPLLRAALKETLR---LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGR 412 +P A + E R + P+G+ + S D+ +Q + IP GT + L S+ + Sbjct: 325 MGDQAHMPYTTAVIHEVQRFGDIVPLGV--THMTSRDIEVQGFRIPKGTTLITNLSSVLK 382 Query: 413 NAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 + A++ +P R++P+ +LD +G + +PF G R CLG LA E+ L +L+HF Sbjct: 383 DEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF 442 Query: 472 LVETLTQE---DIKMVYSFILRP 491 T + V++F++ P Sbjct: 443 SFSVPTGQPRPSHHGVFAFLVSP 465 >3QZ1-A nrPDB Length = 496 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 54/172 (31%), Positives = 83/172 (48%), Gaps = 7/172 (4%) Query: 304 IKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE---SLAAAASISEHPQKATT 360 + + ++L G +TTA L + L +P++Q+ L++E L AS S K Sbjct: 280 VHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELGPGASCSRVTYKDRA 339 Query: 361 ELPLLRAALKETLRLYPV-GLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPR 419 LPLL A + E LRL PV L L + + Y IP G +V L + ++ + Sbjct: 340 RLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVWEQ 399 Query: 420 PERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 P + P R+L+ G N + FG G R CLG LA E+ ++L +L+ F Sbjct: 400 PHEFRPDRFLE---PGANPSALAFGCGARVCLGESLARLELFVVLARLLQAF 448 >5FOI-A nrPDB Length = 408 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 55/190 (28%), Positives = 89/190 (46%), Gaps = 26/190 (13%) Query: 290 VAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAA 349 V E LLK E++ + + N++ L A +T+A + +++ L R+P+ AA Sbjct: 223 VTERLLKGEITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPET-----------AA 271 Query: 350 SISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYS 409 + E P+ L+ A+ E LR + + L R ++D+VL ++ I AG + + L S Sbjct: 272 ELREQPE-------LMPNAVDELLRYHSIADGLRRAATADIVLGDHTIRAGDGLIILLSS 324 Query: 410 LGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 + F + DI R HHV FG+G QCLG+ LA EM + L + + Sbjct: 325 ANHDGNTF------GAEATFDIHRPAR--HHVAFGYGPHQCLGQNLARLEMEVTLGKLFR 376 Query: 470 HFLVETLTQE 479 L QE Sbjct: 377 RVPALRLAQE 386 >5UYS-A nrPDB Length = 494 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 49/170 (28%), Positives = 88/170 (51%), Gaps = 6/170 (3%) Query: 310 ELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKAT-TELPLLRAA 368 ++ V+TT + TL L NP V++ L +E + S P + L LL A Sbjct: 280 DIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEE-IDQNVGFSRTPTISDRNRLLLLEAT 338 Query: 369 LKETLRLYPVG-LFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 ++E LRL PV + + + D + + + GT V + L++L N + +P+++ P+R Sbjct: 339 IREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPER 398 Query: 428 WLDIRGS---GRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVE 474 +L+ G+ + ++PFG G R C+G LA E+ L++ +L+ F +E Sbjct: 399 FLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 448 >6IQ5-A nrPDB Length = 463 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 51/197 (25%), Positives = 84/197 (42%), Gaps = 4/197 (2%) Query: 297 AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ 356 A L LE + A ++ S DT + L L R PDVQ ++ E Sbjct: 246 ARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCM 305 Query: 357 KATTELPLLRAALKETLRLYP-VGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAA 415 LP + A L E +R V + + +++ + YHIP T+V V +S+ + Sbjct: 306 GDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPV 365 Query: 416 LFPRPERYNPQRWLDIRG---SGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFL 472 +P PE ++P R+LD G + F G R+C+G L++ ++ L + + Sbjct: 366 KWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCD 425 Query: 473 VETLTQEDIKMVYSFIL 489 E KM +S+ L Sbjct: 426 FRANPNEPAKMNFSYGL 442 >3S79-A nrPDB Length = 503 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 102/217 (47%), Gaps = 25/217 (11%) Query: 291 AELLL---KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAA 347 EL+L + +L+ E + +E+ + DT + L LF +A++P+V++ + +E Sbjct: 280 TELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKE---I 336 Query: 348 AASISEHPQKATT--ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQV 405 I E K +L ++ + E++R PV + R D V+ Y + GT + Sbjct: 337 QTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNI-- 394 Query: 406 FLYSLGRNAAL--FPRPERYNPQRWLDIRGSGRNF---HHVPFGFGMRQCLGRRLAEAEM 460 + ++GR L FP+P + + + +N + PFGFG R C G+ +A M Sbjct: 395 -ILNIGRMHRLEFFPKPNEFTLENF------AKNVPYRYFQPFGFGPRGCAGKYIAMVMM 447 Query: 461 LLLLHHVLKHFLVETL---TQEDIKMVYSFILRPGTS 494 +L +L+ F V+TL E I+ ++ L P + Sbjct: 448 KAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDET 484 >6DWN-A nrPDB Length = 491 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 90/202 (44%), Gaps = 8/202 (3%) Query: 296 KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHP 355 +LS E I ++L DT + +L L NP VQ+ + QE L S P Sbjct: 272 NVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKI-QEELDTVIGRSRRP 330 Query: 356 QKAT-TELPLLRAALKETLRLYP-VGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRN 413 + + + LP + A + ET R V + + D L+ ++IP G V V + + + Sbjct: 331 RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHD 390 Query: 414 AALFPRPERYNPQRWLDIRGSGRNF---HHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK- 469 L+ P + P+R+L G+ + FG G R+C+G +A E+ L L +L+ Sbjct: 391 QKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 450 Query: 470 -HFLVETLTQEDIKMVYSFILR 490 F V + D+ +Y ++ Sbjct: 451 VEFSVPLGVKVDMTPIYGLTMK 472 >3IBD-A nrPDB Length = 476 Score = 61.6 bits (148), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 47/193 (24%), Positives = 85/193 (44%), Gaps = 7/193 (3%) Query: 297 AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ 356 +E S + + N++ L +TT+ L + + P V + + +E Sbjct: 262 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 321 Query: 357 KATTELPLLRAALKETLR---LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRN 413 ++P A + E R L P+G+ +V+ + Y IP T V + L + + Sbjct: 322 HDRAKMPYTEAVIYEIQRFSDLLPMGV--PHIVTQHTSFRGYIIPKDTEVFLILSTALHD 379 Query: 414 AALFPRPERYNPQRWLDIRGSGRNFH-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF- 471 F +P+ +NP +LD G+ + +PF G R CLG +A AE+ L +L++F Sbjct: 380 PHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 439 Query: 472 LVETLTQEDIKMV 484 + + EDI + Sbjct: 440 MASPVAPEDIDLT 452 >4H1N-A nrPDB Length = 479 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 49/181 (27%), Positives = 78/181 (43%), Gaps = 7/181 (3%) Query: 309 MELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAA 368 + L A +TT+ L + + P V + +++E S ++P A Sbjct: 274 LSLFAAGTETTSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAV 333 Query: 369 LKETLRL---YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNP 425 + E RL P G+ V+ D + Y IP T V L S + F P +NP Sbjct: 334 IHEIQRLGDLIPFGV--PHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNP 391 Query: 426 QRWLDIRGS-GRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVET-LTQEDIKM 483 +LD G+ RN +PF G R CLG +A E+ L +L++F + + + EDI + Sbjct: 392 GHFLDANGALKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDL 451 Query: 484 V 484 Sbjct: 452 T 452 >6AYB-A nrPDB Length = 466 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 39/155 (25%), Positives = 72/155 (46%), Gaps = 3/155 (1%) Query: 326 TLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERV 385 TL + N V + +R+E S ++ L A +KE LR+YP + + R+ Sbjct: 280 TLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRM 339 Query: 386 VSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHH--VPF 443 + Y IP G ++ V GR + P+ ++P+R + R F + VPF Sbjct: 340 ARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTE-RKEHEKFKYGAVPF 398 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQ 478 G G +C+G A ++ ++ +L++F +E + + Sbjct: 399 GAGRHKCIGENFALLQVKSIISILLRYFDMEYIGK 433 >2RFC-A nrPDB Length = 343 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 39/122 (31%), Positives = 53/122 (43%), Gaps = 10/122 (8%) Query: 351 ISEHPQKATTELPLLRAALKETLRLY-PVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYS 409 I E+P L ++ETLR Y P+ R + D + N I G V V+L S Sbjct: 204 IDENPDIIDDALKNRSGFVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQVIVYLGS 263 Query: 410 LGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 R+ F P D+ GR H+ FG G+ CLG LA E + L+ +L Sbjct: 264 ANRDETFFDEP---------DLFKIGRREMHLAFGIGIHMCLGAPLARLEASIALNDILN 314 Query: 470 HF 471 HF Sbjct: 315 HF 316 >4WMZ-A nrPDB Length = 539 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 82/347 (23%), Positives = 138/347 (39%), Gaps = 51/347 (14%) Query: 149 LSPKAVQRFLPMV-DAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 L+ +A + ++P++ + V + F + K N R + T+DV + TI ++ +L G+ Sbjct: 158 LTKEAFKSYVPLIAEEVYKYFRDS--KNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGK 215 Query: 208 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYG 267 + + +L+ S + F P + ++ P + EH+ D + Sbjct: 216 EM----RAKLDTDFAYLY-------SDLDKGFTPIN---FVFPNLPLEHYRKRD----HA 257 Query: 268 DNCIQKIYQELAFNRPQHYTGIVAEL---LLKAELSLEAIKANSMELTA-------GSVD 317 I Y L R ++ +L L+K + +K E+ G Sbjct: 258 QKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQH 317 Query: 318 TTAFPLLMTLFELARNPDVQQILRQESLAA-AASISEHPQKATTELPLLRAALKETLRLY 376 T+A L LA PDVQQ L +E + E E+PLL +KETLR++ Sbjct: 318 TSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMH 377 Query: 377 PVGLFLERVVSSDLVLQN--YHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS 434 L R V D+ + N Y IPAG V V FP ++N RW + S Sbjct: 378 HPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSAS 437 Query: 435 -----------------GRNFHHVPFGFGMRQCLGRRLAEAEMLLLL 464 G + ++PFG G +C+G A ++ +L+ Sbjct: 438 SYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLM 484 >6GMF-A nrPDB Length = 397 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 95/200 (47%), Gaps = 21/200 (10%) Query: 301 LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQK--- 357 L A + + +LTAG V + A LL +A N ++ A ++++HP++ Sbjct: 208 LLAAEVDGEKLTAGEVLSFANTLL-----IAGNETTTSLIGN----ALVALTDHPEQLAA 258 Query: 358 ATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALF 417 A +L L+ A ++E LR + R +D+ + + IPA ++V L S R+ + F Sbjct: 259 AQADLSLVPAVVEEVLRYESPAQCIFRQTMTDVEIGDERIPARSVVLPLLASANRDESRF 318 Query: 418 PRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLT 477 P P+R++ R D +G H+ FG + C+G LA E ++L +L Sbjct: 319 PDPDRFDIHR--DTKG------HLAFGLDIHFCIGAPLARLEAKVMLEVLLARLGDIQRV 370 Query: 478 QEDIKMVYSFILR-PGTSPL 496 +++ SF +R P T PL Sbjct: 371 SQEVSWSPSFFIRSPSTLPL 390 >5E0E-A nrPDB Length = 463 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 94/442 (21%), Positives = 175/442 (39%), Gaps = 62/442 (14%) Query: 73 QELGPIFRYNLGGPRMVCVMLPEDVEKLQQVD-----SLHPCRMILEPWVAYRQHRGHKC 127 ++ G +F +LG PR V ++ + + VD S ++EP RG+ Sbjct: 32 EKYGDVFTVHLG-PRPVVMLYGTEAIREALVDQAEAFSGRGTIAVVEPIF-----RGY-- 83 Query: 128 GVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFS---QALKKKVLQNAR--- 181 GV NG W KA++RF + RDF +++++++ + AR Sbjct: 84 GVVFANGERW--------------KALRRFSLVT---MRDFGMGKRSVEERIQEEARCLV 126 Query: 182 ----GSLTLDVQPSIFHYTIEASNLA--LFGERLGLVGHSPSSASLNFLHALEVMFKSTV 235 S + P+ I A+ + +FGER H F + ++ + Sbjct: 127 EEFRKSQGAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSS 186 Query: 236 QLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLL 295 Q+ + ++ P ++ I Y ++K L P H + LL Sbjct: 187 QVFELFSGFLKYF-PGTHRQISRNLQEILDYIGQSVEKHRATLD---PSHPRDFIDTYLL 242 Query: 296 K---------AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLA 346 + E + + + + L +T++ L + + P V + +++E Sbjct: 243 RMEKEKSNQHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQ 302 Query: 347 AAASISEHPQKATTELPLLRAALKETLR---LYPVGLFLERVVSSDLVLQNYHIPAGTLV 403 S + T++P A + E R L P+G+ V+ D + + Y +P T V Sbjct: 303 VIGSHRLPTLEDRTKMPYTEAVIYEIQRFSDLIPIGV--PHKVTKDTLFRGYLLPKNTEV 360 Query: 404 QVFLYSLGRNAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLGRRLAEAEMLL 462 L S + F +P+ +NP +LD G+ ++ +PF G R CLG +A E+ L Sbjct: 361 YPILSSALHDPQYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFL 420 Query: 463 LLHHVLKHF-LVETLTQEDIKM 483 +L++F L + +DI + Sbjct: 421 FFTTILQNFSLSSPVAPKDIDL 442 >4KPA-A nrPDB Length = 494 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 54/196 (27%), Positives = 87/196 (44%), Gaps = 6/196 (3%) Query: 299 LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ-K 357 L E I+ + +TT+ L L+ L +NP V Q +E AA + P K Sbjct: 273 LDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEE--AARVLVDPVPSYK 330 Query: 358 ATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQN-YHIPAGTLVQVFLYSLGRNAAL 416 +L + L E LRL+P D VL Y + G + V + L R+ + Sbjct: 331 QVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTI 390 Query: 417 FPRP-ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVET 475 + E + P+R+ + ++ PFG G R C+G++ A E L+L +LKHF E Sbjct: 391 WGDDVEEFRPERFENPSAIPQHAFK-PFGNGQRACIGQQFALHEATLVLGMMLKHFDFED 449 Query: 476 LTQEDIKMVYSFILRP 491 T ++ + + L+P Sbjct: 450 HTNYELDIKETLTLKP 465 >2ZBZ-A nrPDB Length = 412 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 93/207 (44%), Gaps = 31/207 (14%) Query: 289 IVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAA 348 +VA+ L E+ E + + +M L +TTA +++ L +P+ LR + Sbjct: 219 LVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADR---- 274 Query: 349 ASISEHPQKATTELPLLRAALKETLRLYPVG-LFLERVVSSDLVLQNYHIPAGTLVQVFL 407 L+ A++E LR + + RV ++D+ ++ I AG V V Sbjct: 275 --------------SLVPGAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVN 320 Query: 408 YSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHV 467 R+ ++ P+ LDI S R HH+ FGFG+ QCLG+ LA E+ ++L+ + Sbjct: 321 SIANRDGTVYEDPD------ALDIHRSAR--HHLAFGFGVHQCLGQNLARLELEVILNAL 372 Query: 468 LKHFLVETLTQEDIKMVYSFILRPGTS 494 + L V +LRPGT+ Sbjct: 373 MDRVPTLRLAVP----VEQLVLRPGTT 395 >1WIY-A nrPDB Length = 389 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 41/110 (37%), Positives = 55/110 (50%), Gaps = 7/110 (6%) Query: 369 LKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRW 428 +E LRLYP L R + L+L +P GT + + Y R FP E + P+R+ Sbjct: 258 FQEALRLYPPAWILTRRLERPLLLGEDRLPQGTTLVLSPYVTQR--LYFPEGEAFQPERF 315 Query: 429 LDIRG--SGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL 476 L RG SGR F PFG G R CLGR A E ++L + F ++ L Sbjct: 316 LAERGTPSGRYF---PFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLDPL 362 >4UBS-A nrPDB Length = 393 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 50/165 (30%), Positives = 76/165 (46%), Gaps = 15/165 (9%) Query: 310 ELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKAT---TELPLLR 366 +L G+VD L TL +A + ++ + ++ HP++ E L+ Sbjct: 211 QLNRGTVDRAELVSLATLLLIAGHETTANMISLGTF----TLLRHPEQLAELRAEPGLMP 266 Query: 367 AALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQ 426 AA++E LR + L RV + D+ + I A V + R+AA F P+ Sbjct: 267 AAVEELLRFLSIADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPD----- 321 Query: 427 RWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 LD S R HHV FGFG+ QCLG+ LA AEM + L + + Sbjct: 322 -ALDWHRSAR--HHVAFGFGIHQCLGQNLARAEMEIALGTLFERL 363 >2HI4-A nrPDB Length = 495 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 56/239 (23%), Positives = 100/239 (41%), Gaps = 23/239 (9%) Query: 270 CIQKIYQELAFNRPQHYTGIVAELLLKAE------LSLEAIKANSMELTAGSVDTTAFPL 323 +Q+ YQ+ N + TG + + K + E I ++ DT + Sbjct: 243 TVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAI 302 Query: 324 LMTLFELARNPDVQQILRQESLAAAAS-----ISEHPQKATTELPLLRAALKETLRLYPV 378 +L L P++Q+ +++E +S+ PQ LP L A + ET R Sbjct: 303 SWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQ-----LPYLEAFILETFRHSSF 357 Query: 379 GLF-LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRN 437 F + + D L ++IP V V + + + L+ P + P+R+L G+ N Sbjct: 358 LPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAIN 417 Query: 438 F----HHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKH--FLVETLTQEDIKMVYSFILR 490 + FG G R+C+G LA+ E+ L L +L+ F V + D+ +Y ++ Sbjct: 418 KPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMK 476 >3MGX-A nrPDB Length = 415 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 43/183 (23%), Positives = 78/183 (42%), Gaps = 26/183 (14%) Query: 282 RPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILR 341 R + +V+ L+ +L+++ + N + G +TT + + LA P + LR Sbjct: 222 RKEPGDDLVSTLVTDDDLTIDDVLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTALR 281 Query: 342 QESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGT 401 S + ++E LR + + RV ++D+ + +P+GT Sbjct: 282 DGSAD------------------VDTVVEEVLRWTSPAMHVLRVTTADVTINGRDLPSGT 323 Query: 402 LVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEML 461 V +L + R+ A F P+ + P R + H+ FG GM CLG LA E+ Sbjct: 324 PVVAWLPAANRDPAEFDDPDTFLPGR--------KPNRHITFGHGMHHCLGSALARIELS 375 Query: 462 LLL 464 ++L Sbjct: 376 VVL 378 >6HQG-A nrPDB Length = 425 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 45/166 (27%), Positives = 72/166 (43%), Gaps = 25/166 (15%) Query: 306 ANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLL 365 N + L G DTT + ++ L +NPD + LR E+P L+ Sbjct: 254 GNLILLIVGGNDTTRNTISGSVLALHQNPDQDRKLR-----------ENPG-------LI 295 Query: 366 RAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNP 425 A + ET+R ++ R D L I G V ++ S R+ + RP Y Sbjct: 296 PAMVSETIRWQTPLAYMRRRAKRDFELGGKTIREGDKVAMWYVSGNRDEEVIDRPNDY-- 353 Query: 426 QRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 W++ R H+ FGFG+ +C+G RLAE ++ ++ +L F Sbjct: 354 --WIE---RPRVRQHLSFGFGVHRCVGNRLAELQLKIIWEEILARF 394 >5E58-A nrPDB Length = 493 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 46/180 (25%), Positives = 81/180 (45%), Gaps = 7/180 (3%) Query: 309 MELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAA 368 + L +TT+ L + + P V + +++E S + T++P A Sbjct: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRTKMPYTDAV 352 Query: 369 LKETLR---LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNP 425 + E R L P+G V+ D + + Y +P T V L S + F +P +NP Sbjct: 353 IHEIQRFSDLAPIGA--PHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYFEQPGTFNP 410 Query: 426 QRWLDIRGS-GRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLV-ETLTQEDIKM 483 +LD G+ ++ +PF G R CLG +A E+ L +L++F V ++ +DI + Sbjct: 411 DHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSSSVAPKDIDL 470 >6B11-A nrPDB Length = 440 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 52/187 (27%), Positives = 84/187 (44%), Gaps = 29/187 (15%) Query: 288 GIVAELLLKAE---LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQES 344 G++ ++ +A LS + N++ L A +TTA + M++ L ++P + L Sbjct: 250 GMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLLQHPTAWREL---- 305 Query: 345 LAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQ 404 T LL A+ E LR + L R ++D+ + + I AG + Sbjct: 306 --------------TVNPGLLPGAVDELLRYLSIADGLRRSATADIEIDGHTIRAGDGLV 351 Query: 405 VFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLL 464 L + R+ A+F PE + DI S R HV FG+G QCLG+ LA E+ + L Sbjct: 352 FLLAAANRDEAVFSEPEAF------DIHRSARR--HVAFGYGPHQCLGQNLARMELEVAL 403 Query: 465 HHVLKHF 471 VL+ Sbjct: 404 GAVLERL 410 >5VWS-A nrPDB Length = 393 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 51/196 (26%), Positives = 82/196 (41%), Gaps = 28/196 (14%) Query: 302 EAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTE 361 E + S+ L AG + TT + T+ L +P+ ++ +R + Sbjct: 222 EVVNTASLLLLAGHLTTTVL-IGNTMLCLWDHPEAEKAVRADP----------------- 263 Query: 362 LPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPE 421 L+ AAL+E+LRL L RV + D+ + IPA V ++ S + FP PE Sbjct: 264 -SLIPAALEESLRLRSPFLQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPE 322 Query: 422 RYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFL-VETLTQED 480 R++ R + H+ FG G+ CLG +L E + L +L F + +E Sbjct: 323 RFDLHR--------QTTGHIAFGHGVHFCLGAQLGRLEGRIALERLLGRFTEIHPWPREG 374 Query: 481 IKMVYSFILRPGTSPL 496 I S I P+ Sbjct: 375 ISFYQSAIFGASRMPV 390 >5JLC-A nrPDB Length = 515 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 78/345 (22%), Positives = 131/345 (37%), Gaps = 46/345 (13%) Query: 149 LSPKAVQRFLPMV-DAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 L+ +A R++P++ + + + F + K+ +N G +DV S TI ++ +L G+ Sbjct: 140 LTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSG--IVDVMVSQPEMTIFTASRSLLGK 197 Query: 208 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYG 267 + +L+ S + F P + ++ P + EH+ D Q Sbjct: 198 EM----RDKLDTDFAYLY-------SDLDKGFTPIN---FVFPNLPLEHYRKRDHAQQAI 243 Query: 268 DNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTA-------GSVDTTA 320 + +E ++ EL+ K + K E+ G T+A Sbjct: 244 SGTYMSLIKERREKNDIQNRDLIDELM-KNSTYKDGTKMTDQEIANLLIGVLMGGQHTSA 302 Query: 321 FPLLMTLFELARNPDVQQILRQESLAA-AASISEHPQKATTELPLLRAALKETLRLYPVG 379 L LA PDVQ+ L QE + E +PLL +KETLRL+ Sbjct: 303 ATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPL 362 Query: 380 LFLERVVSSDLVLQN--YHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS--- 434 L R V D+ + N Y +P V V FP+P +N RW S Sbjct: 363 HSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSA 422 Query: 435 ---------------GRNFHHVPFGFGMRQCLGRRLAEAEMLLLL 464 G + ++PFG G +C+G A ++ +L+ Sbjct: 423 AGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLM 467 >3SN5-A nrPDB Length = 491 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 48/199 (24%), Positives = 87/199 (43%), Gaps = 26/199 (13%) Query: 300 SLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE------SLAAAASISE 353 LE K + + L A +T +LF++ RNP+ + +E + S+ Sbjct: 255 DLEKAKTHLVVLWASQANTIP-ATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEG 313 Query: 354 HP----QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQ----NYHIPAGTLVQV 405 +P Q +LP+L + +KE+LRL L + R D L +Y+I ++ + Sbjct: 314 NPICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIAL 372 Query: 406 FLYSLGRNAALFPRPERYNPQRWLDIRGSGRN----------FHHVPFGFGMRQCLGRRL 455 + + + ++P P + R+LD G + ++++PFG G C GR Sbjct: 373 YPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLF 432 Query: 456 AEAEMLLLLHHVLKHFLVE 474 A E+ L +L +F +E Sbjct: 433 AIHEIKQFLILMLSYFELE 451 >3RWL-A nrPDB Length = 426 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 45/173 (26%), Positives = 70/173 (40%), Gaps = 25/173 (14%) Query: 299 LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKA 358 ++ E N + L G DTT + + L +NPD A + +P Sbjct: 250 MTPEEYLGNVLLLIVGGNDTTRNSMTGGVLALHKNPD-----------QFAKLKANPALV 298 Query: 359 TTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFP 418 T +P E +R + R +D L I G V ++ YS R+ + Sbjct: 299 ETMVP-------EIIRWQTPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVID 351 Query: 419 RPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 RPE + R R H+ FGFG+ +C+G RLAE ++ +L +L F Sbjct: 352 RPEEFIIDR-------PRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRF 397 >3JUS-A nrPDB Length = 461 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 37/141 (26%), Positives = 67/141 (47%), Gaps = 1/141 (0%) Query: 361 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP 420 +L LL +KETLRL P + + R+ + + Y IP G V V R + Sbjct: 311 DLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVER 370 Query: 421 ERYNPQRWL-DIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQE 479 +NP R+L D SG F +VPFG G +C+G A ++ + +L+ + + + Sbjct: 371 LDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGY 430 Query: 480 DIKMVYSFILRPGTSPLLTFR 500 + Y+ ++ +P++ ++ Sbjct: 431 FPTVNYTTMIHTPENPVIRYK 451 >6F0B-A nrPDB Length = 395 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 43/151 (28%), Positives = 71/151 (47%), Gaps = 27/151 (17%) Query: 311 LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALK 370 L G DTTA + ++L A P+ + + EHP++ +PLL ++ Sbjct: 230 LIVGGYDTTASTISLSLVSYALQPEKFSV-----------VHEHPER----IPLL---VE 271 Query: 371 ETLRLYPVG-LFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWL 429 E LR + V L L R+ + D+ + + AG +V L R+ ++FP P+ + R Sbjct: 272 ELLRYHTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR-- 329 Query: 430 DIRGSGRNFHHVPFGFGMRQCLGRRLAEAEM 460 + HV FG+G QC+G+ LA E+ Sbjct: 330 ------PSVPHVGFGYGPHQCVGQALARVEL 354 >3TYW-A nrPDB Length = 417 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 88/205 (42%), Gaps = 29/205 (14%) Query: 282 RPQHYTGIVAELLLKAELSLEAIKAN-SMELTAGSVDTTAFPLLMTLFELARNPDVQQIL 340 R + +V + L+ ++ E + + + + AG TT+ L TL L R P++ L Sbjct: 217 RDDLISKLVTDHLVPGNVTTEQLLSTLGITINAGRETTTSMIALSTLLLLDR-PELPAEL 275 Query: 341 RQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE-RVVSSDLVLQNYHIPA 399 R++ L+ AA+ E LR+ V + RV + D+ L +PA Sbjct: 276 RKDP------------------DLMPAAVDELLRVLSVADSIPLRVAAEDIELSGRTVPA 317 Query: 400 GTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAE 459 V L + F PER + R + HHV FG+G+ QC+G+ LA E Sbjct: 318 DDGVIALLAGANHDPEQFDDPERVDFHRT--------DNHHVAFGYGVHQCVGQHLARLE 369 Query: 460 MLLLLHHVLKHFLVETLTQEDIKMV 484 + + L +L+ L E ++V Sbjct: 370 LEVALETLLRRVPTLRLAGERDQVV 394 >2W0A-A nrPDB Length = 455 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 45/154 (29%), Positives = 67/154 (43%), Gaps = 8/154 (5%) Query: 326 TLFELARNPDVQQIL---RQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382 TL EL R+ D + E S+S H A ++P L LKETLRL+P + L Sbjct: 268 TLIELMRHRDAYAAVIDELDELYGDGRSVSFH---ALRQIPQLENVLKETLRLHPPLIIL 324 Query: 383 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG--RNFHH 440 RV + +Q + I G LV R FP P + P R+ R + Sbjct: 325 MRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTW 384 Query: 441 VPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVE 474 +PFG G +C+G A ++ + +L+ + E Sbjct: 385 IPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFE 418 >5FYF-A nrPDB Length = 470 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 37/151 (24%), Positives = 70/151 (46%), Gaps = 10/151 (6%) Query: 341 RQESLAAAASISEHP---QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHI 397 R +++E P +K + L+ + E +R ++ R+ D+ L I Sbjct: 313 RNSMSGGLVAMNEFPREFEKLKAKPELIPNMVSEIIRWQTPLAYMRRIAKQDVELGGQTI 372 Query: 398 PAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAE 457 G V ++ S R+ F NP +++ R RN H+ FG+G+ +C+G RLAE Sbjct: 373 KKGDRVVMWYASGNRDERKFD-----NPDQFIIDRKDARN--HMSFGYGVHRCMGNRLAE 425 Query: 458 AEMLLLLHHVLKHFLVETLTQEDIKMVYSFI 488 ++ +L +LK F + +E ++ +F+ Sbjct: 426 LQLRILWEEILKRFDNIEVVEEPERVQSNFV 456 >5IT1-A nrPDB Length = 399 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 34/109 (31%), Positives = 52/109 (47%), Gaps = 9/109 (8%) Query: 364 LLRAALKETLRLYPVGLF-LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPER 422 L+ A++E LR +G F ERV + D + I G V L S + A PER Sbjct: 269 LIGNAVEELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPER 328 Query: 423 YNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 ++ R R H+ FGFG QC+G++LA E+ ++ + + F Sbjct: 329 FDITR--------RPAPHLAFGFGAHQCIGQQLARIELQIVFGTLFRRF 369 >3ABB-A nrPDB Length = 408 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 11/121 (9%) Query: 347 AAASISEHPQKATTEL---PLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLV 403 A ++ +HP++ L + ++E LR V + R+ D+ + I AG V Sbjct: 255 GALTLIQHPEQIDVLLRDPGAVSGVVEELLRFTSVSDHIVRMAKEDIEVGGATIKAGDAV 314 Query: 404 QVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLL 463 V + + R+A + P+ ++ +R HHV FG G+ QCLG+ LA AE+ + Sbjct: 315 LVSITLMNRDAKAYENPDIFDARR--------NARHHVGFGHGIHQCLGQNLARAELEIA 366 Query: 464 L 464 L Sbjct: 367 L 367 >2X2N-A nrPDB Length = 475 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 28/119 (23%), Positives = 57/119 (47%), Gaps = 5/119 (4%) Query: 361 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP 420 E+P +E++R P L L R V +D+ + +Y +P G ++ + FP P Sbjct: 324 EMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEP 383 Query: 421 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQE 479 R++P+R + G+ + FG G+ +C+G++ ++ +L + + + L E Sbjct: 384 RRWDPERDEKVEGA-----FIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDE 437 >2XKR-A nrPDB Length = 398 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 56/239 (23%), Positives = 96/239 (40%), Gaps = 27/239 (11%) Query: 243 SLSRWISPKVWKEHFE-AWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSL 301 L ++S V +E F+ D Y D I A + +V+ + LS Sbjct: 158 DLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLVSSEVDGERLSD 217 Query: 302 EAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTE 361 + + ++ + G +TT L +L RN D +L+++ Sbjct: 218 DELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDP----------------- 260 Query: 362 LPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPE 421 LL A++E LR + RV+++D + AG + + S + A+F PE Sbjct: 261 -SLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPE 319 Query: 422 RYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED 480 +++ QR + H+ FGFG CLG +LA E+ L+ VL+ L +D Sbjct: 320 KFDVQRNPN--------SHLAFGFGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADD 370 >6HQW-A nrPDB Length = 445 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 81/372 (21%), Positives = 149/372 (40%), Gaps = 44/372 (11%) Query: 110 RMILEPWVAYRQHRGHKCGVFLLNGPE-----WRFNRLRLNP---DVLSPKAVQRFLPMV 161 R+ P+ AY HK + + + PE W++ + + DV K +R LPM Sbjct: 70 RVPDSPYGAYWNVASHKAIMHVESLPELFSSSWQYGGITIGDPPEDVDPQKLAERQLPMF 129 Query: 162 DAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASL 221 A+ R ++ V + ++++ I T + +GER V + Sbjct: 130 IAMDRPDHTGQRRTVAPAFTPAKMVEMEAEIRRRTASVLDSLPWGERFDWVDKVSIELTT 189 Query: 222 NFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQY-GDNCIQKIYQELAF 280 L L + +L+ S W E D F + G+ + +Q L Sbjct: 190 GMLAILFGFPWADRRLLTF---WSDWAGDVELTLARELADTRFGFLGE--MAHYFQRLWG 244 Query: 281 NRPQHY-TGIVAELLLKAE----LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPD 335 R Q +G + +++ +E +S + N + L G DTT + + L + PD Sbjct: 245 ARMQAPPSGDLISMMIHSEAMNHMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPD 304 Query: 336 VQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNY 395 +++L +++ L+ A++E +R + R ++D L Sbjct: 305 QRELLERDA------------------SLIPNAVQECIRYVTPLAHMRRTATADTELFGN 346 Query: 396 HIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRL 455 I AG V ++ S R+ +F NP + + R + R H+ FG G+ +C+G RL Sbjct: 347 QIKAGEKVILWYISANRDETVFE-----NPDKLMVDRPNARR--HLSFGHGIHRCVGARL 399 Query: 456 AEAEMLLLLHHV 467 AE ++ +LL + Sbjct: 400 AELQLRILLEEM 411 >1UE8-A nrPDB Length = 367 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 32/113 (28%), Positives = 55/113 (48%), Gaps = 8/113 (7%) Query: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 A++E LR P + RV + +++ I G LV+V++ S R+ +F P+ + P R Sbjct: 243 AVEEALRFSPPVMRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDR 302 Query: 428 WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED 480 + H+ FG G+ CLG LA E + L K F V+ + +++ Sbjct: 303 TPN--------PHLSFGSGIHLCLGAPLARLEARIALEEFAKKFRVKEIVKKE 347 >4RM4-A nrPDB Length = 396 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/235 (23%), Positives = 96/235 (40%), Gaps = 44/235 (18%) Query: 249 SPKVWKEHFEAWDCIFQYGDNCIQKIYQ------ELAFNRPQHYTGIVAELLLKAELSLE 302 +PK E EA + D C +++ E N+P+ + +L++AE + E Sbjct: 168 TPKDKSE--EAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQD---IISILVEAEETGE 222 Query: 303 AIKAN------SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ 356 + ++ L AG+ TT + ++ + P V + LR HP+ Sbjct: 223 KLSGEELIPFCTLLLVAGNETTTNL-ISNAMYSILETPGVYEELRS-----------HPE 270 Query: 357 KATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAAL 416 L+ A++E LR L R+ D + + I G +V F+ S R+ A Sbjct: 271 -------LMPQAVEEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAK 323 Query: 417 FPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 F RP ++ +R + H+ FG G+ CLG LA E + L ++ F Sbjct: 324 FDRPHMFDIRRHPN--------PHIAFGHGIHFCLGAPLARLEANIALTSLISAF 370 >5YHJ-A nrPDB Length = 413 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 45/172 (26%), Positives = 75/172 (43%), Gaps = 25/172 (14%) Query: 323 LLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382 +L T+ L + PDV++ + E + + TE ++E R YP Sbjct: 248 VLFTVLALHQFPDVKEQV------------ERGEVSKTEF------VQEVRRFYPFFPVA 289 Query: 383 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVP 442 V +D Y P GTL + LY + +++ P+R++P R+ D + S NF +P Sbjct: 290 AARVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRFKDWKESPFNF--IP 347 Query: 443 FGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVE---TLTQEDIKMVYSFILRP 491 G G R E + +L V++ F E T+ +D+ YSF+ P Sbjct: 348 QGGGDVDFGHRCAGEHVTIAILAQVIELFTKEYAYTVPPQDLS--YSFVDMP 397 >2WX2-A nrPDB Length = 473 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 26/119 (21%), Positives = 59/119 (49%), Gaps = 5/119 (4%) Query: 361 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP 420 E+P ++E++R P L + R+V +++ + +Y +P G ++ + FP P Sbjct: 324 EMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNP 383 Query: 421 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQE 479 ++P+R + G+ + FG G+ +C+G++ A ++ +L + + + L E Sbjct: 384 RLWDPERDEKVDGA-----FIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDE 437 >2WIO-A nrPDB Length = 431 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 37/137 (27%), Positives = 64/137 (46%), Gaps = 9/137 (6%) Query: 350 SISEHPQ--KATTELP-LLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVF 406 ++ EHP A E P + A ++E LR P ++R + + IPA +V + Sbjct: 276 TLDEHPAHWDAAAEDPGRIPAIVEEVLRYRPPFPQMQRTTTKATEVAGVPIPADVMVNTW 335 Query: 407 LYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHH 466 + S R++ P+R++P R SG + FG G+ CLG LA E + L Sbjct: 336 VLSANRDSDAHDDPDRFDPS-----RKSG-GAAQLSFGHGVHFCLGAPLARLENRVALEE 389 Query: 467 VLKHFLVETLTQEDIKM 483 ++ F T+ ++D ++ Sbjct: 390 IIARFGRLTVDRDDERL 406 >5OFQ-A nrPDB Length = 409 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 94/222 (42%), Gaps = 33/222 (14%) Query: 271 IQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANS------MELTAGSVDTTAFPLL 324 +Q ++E+ R Q+ + LLL+AE+ E + + L AG+ +TT + Sbjct: 193 LQGYFKEIIAERQQNKQEDLISLLLEAEIDGEHLTEEEVLGFCILLLVAGN-ETTTNLIT 251 Query: 325 MTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLER 384 + + + DVQ +R++ + L+ ++ETLR YP + R Sbjct: 252 NGVRYMTEDVDVQNEVRRD------------------ISLVPNLVEETLRYYPPIQAIGR 293 Query: 385 VVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFG 444 + + D+ L I G V + S R++A F P+ + R + HV FG Sbjct: 294 IAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR--------KTNPHVSFG 345 Query: 445 FGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYS 486 FG+ CLG LA E + +L+ + + +K + S Sbjct: 346 FGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDS 387 >3EL3-A nrPDB Length = 467 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 46/185 (24%), Positives = 79/185 (42%), Gaps = 9/185 (4%) Query: 311 LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLR---A 367 LT GS +T A ++ L LA +P+ +R E A ++ A ++ LR Sbjct: 272 LTPGS-ETIASTIMWLLQALADHPEHADRIRDEVEA----VTGGRPVAFEDVRKLRHTGN 326 Query: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 + E +RL P L R ++ L Y IPAG + Y++ R+ + ++P R Sbjct: 327 VIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDR 386 Query: 428 WLDIRGSG-RNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYS 486 WL R + + PF G R+C + A++ L+ + + E + + + Sbjct: 387 WLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVG 446 Query: 487 FILRP 491 LRP Sbjct: 447 ITLRP 451 >3ABA-A nrPDB Length = 403 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 52/107 (48%), Gaps = 9/107 (8%) Query: 364 LLRAALKETLRLYPVGLFL-ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPER 422 L+ A++E LR +G F ERV + D+ L I G V + + + A PER Sbjct: 269 LVGNAVEELLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPER 328 Query: 423 YNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 ++ R R H+ FGFG QC+G++LA E+ ++ + + Sbjct: 329 FDITR--------RPAPHLAFGFGAHQCIGQQLARIELQIVFETLFR 367 >3R9C-A nrPDB Length = 418 Score = 48.9 bits (115), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 30/113 (26%), Positives = 49/113 (43%), Gaps = 8/113 (7%) Query: 367 AALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQ 426 A ++ET+R P + R DL + + +P G + + L + R+ + P+R++P Sbjct: 291 AVIEETMRYDPPVQLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPD 350 Query: 427 RWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQE 479 R H+ FG G CLG LA E + L + F L+ E Sbjct: 351 RA--------QIRHLGFGKGAHFCLGAPLARLEATVALPALAARFPEARLSGE 395 >3TKT-A nrPDB Length = 450 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 10/126 (7%) Query: 364 LLRAALKETLR-LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPER 422 LL ++E +R PV F+ R ++D L I AG + + + + A FP P + Sbjct: 321 LLPGIVEEAIRWTTPVQHFM-RTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRK 379 Query: 423 YNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIK 482 ++P R + H+ FG G QCLG LA EM +LL +L L E + Sbjct: 380 FDPTRPAN--------RHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKR 431 Query: 483 MVYSFI 488 + +F+ Sbjct: 432 VNSTFV 437 >5YSW-A nrPDB Length = 441 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/162 (32%), Positives = 74/162 (45%), Gaps = 33/162 (20%) Query: 302 EAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTE 361 E I ++ L AG DTTA L + +F L + P LR + A ++ E Sbjct: 266 ELINIANLLLIAG-YDTTASMLGLGIFVLLQRPAQLATLRDDPSRIADAVEE-------- 316 Query: 362 LPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPE 421 LLR L + G+F R DL HIPAG+ V V + + R+A +P P+ Sbjct: 317 --LLR-----YLSVVNPGIF--RFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDPD 367 Query: 422 RYNPQRWLDI---RGSGRNFHHVPFGFGMRQCLGRRLAEAEM 460 LD+ RG H+ FG G+ QCLG++LA EM Sbjct: 368 -------LDLTRPRGP-----HLAFGHGVHQCLGQQLARMEM 397 >3A1L-A nrPDB Length = 425 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 33/103 (32%), Positives = 48/103 (46%), Gaps = 8/103 (7%) Query: 367 AALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQ 426 AA++E +R P + R D+ L ++ IP G+ V L S R+ A FP P+ + Sbjct: 289 AAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVH 348 Query: 427 RWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 R + V FG G+ CLG LA AE + L +L Sbjct: 349 RAAE--------RQVGFGLGIHYCLGATLARAEAEIGLRALLD 383 >3A50-A nrPDB Length = 411 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 64/266 (24%), Positives = 106/266 (39%), Gaps = 49/266 (18%) Query: 210 GLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDN 269 GL+ P+ ++ + E F+ VQ++ L P ++ F AW + Sbjct: 124 GLLAGLPTDGPVDLMR--EYAFQIPVQVICELLGL-----PAEDRDDFSAWSSVLVDDSP 176 Query: 270 CIQK----------IYQELAFNRPQHYTGIVAELLLKAE-----LSLEAIKANSMELTAG 314 K + L R + +++ LL ++ LS E + A +M L Sbjct: 177 ADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDMDGDRLSQEELVAMAMLLLIA 236 Query: 315 SVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLR 374 +TT + + L +PD +++L +E P L+ +A++E LR Sbjct: 237 GHETTVNLIGNGVLALLTHPDQRKLL-----------AEDPS-------LISSAVEEFLR 278 Query: 375 L-YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRG 433 PV R + D+ IPAG +V + L + R+A P P+R + R Sbjct: 279 FDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITR----DA 334 Query: 434 SGRNFHHVPFGFGMRQCLGRRLAEAE 459 SG F FG G+ CLG +LA E Sbjct: 335 SGGVF----FGHGIHFCLGAQLARLE 356 >1UED-A nrPDB Length = 406 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 69/307 (22%), Positives = 120/307 (39%), Gaps = 33/307 (10%) Query: 197 IEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEH 256 +E + +L +RL L+ SA L L A V + +L+ +PR R ++ + Sbjct: 124 MEPAIQSLIDDRLDLLEAEGPSADLQGLFADPVGAHALCELLGIPRDDQREFVRRIRRNA 183 Query: 257 FEAWDCIFQYGDNCIQKIYQE--LAFNRPQHYTGIVAELLLK--AELSLEAIKANSMELT 312 + + D+ Y + LA R G++ ++ ++ E +K L Sbjct: 184 DLSRGLKARAADSAAFNRYLDNLLARQRADPDDGLLGMIVRDHGDNVTDEELKGLCTALI 243 Query: 313 AGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKET 372 G V+T A + + L NP ++L E P+KA + E Sbjct: 244 LGGVETVAGMIGFGVLALLDNPGQIELL-----------FESPEKAER-------VVNEL 285 Query: 373 LR-LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDI 431 +R L PV R+ D+V+ I AG V + R+ AL P P+ + R Sbjct: 286 VRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDVLDANRAA-- 343 Query: 432 RGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF--LVETLTQEDIKMVYSFIL 489 V FG G+ C+G LA + + + + + F L + E++K +F+ Sbjct: 344 ------VSDVGFGHGIHYCVGAALARSMLRMAYQTLWRRFPGLRLAVPIEEVKYRSAFVD 397 Query: 490 RPGTSPL 496 P P+ Sbjct: 398 CPDQVPV 404 >5LIE-A nrPDB Length = 414 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/161 (26%), Positives = 65/161 (40%), Gaps = 26/161 (16%) Query: 311 LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALK 370 L + +TT + L LA NPD Q LR ++ LL A++ Sbjct: 250 LFSAGAETTRNSIAGGLLALAENPDQLQTLR------------------SDFELLPTAIE 291 Query: 371 ETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLD 430 E +R R S + L I AG V V+ S R+ ++F R + ++ R Sbjct: 292 EIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITR--- 348 Query: 431 IRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 + H+ FG G+ CLG LA E+ +L +L F Sbjct: 349 -----KPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRF 384 >5DE9-A nrPDB Length = 410 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 38/127 (29%), Positives = 56/127 (44%), Gaps = 12/127 (9%) Query: 368 ALKETLRLYP--VGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNP 425 A+ E LR P + L R+ D+ ++ I AG V V + R+ +FP P+R + Sbjct: 277 AIDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDF 336 Query: 426 QRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF--LVETLTQEDIKM 483 +R + HV FGFG C G LA E LL+ VL L + ED+ Sbjct: 337 ERSPN--------PHVSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPF 388 Query: 484 VYSFILR 490 ++R Sbjct: 389 KKGALIR 395 >4WPZ-A nrPDB Length = 397 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 50/202 (24%), Positives = 84/202 (41%), Gaps = 34/202 (16%) Query: 278 LAFNRPQHYTGIVAELLLKAE----LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARN 333 +A R +++EL+ ++ L+ I A S+ + + +TTA + M L L N Sbjct: 192 IAVKRENPADDLISELIAISDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHN 251 Query: 334 PDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPV---GLFLERVVSSDL 390 P+ LR A + A+ E LR P+ G + R+ ++++ Sbjct: 252 PEELDKLRDNREA------------------IPKAVDELLRFVPLTTTGGIIPRLTTAEV 293 Query: 391 VLQNYHI-PAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQ 449 L + PAG +V + + R+ +F ER N R N H+ FG G+ Sbjct: 294 ELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTR--------ENNPHLAFGAGIHH 345 Query: 450 CLGRRLAEAEMLLLLHHVLKHF 471 CLG +LA E+ L +L Sbjct: 346 CLGAQLARIELQEALGAILDRM 367 >6HQD-A nrPDB Length = 420 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/134 (25%), Positives = 57/134 (42%), Gaps = 10/134 (7%) Query: 341 RQESLAAAASISEHPQ---KATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHI 397 R +A + +PQ K LL + + E +R + R D+ + I Sbjct: 265 RSSMSGSAMACHLYPQEFDKVRNNRALLASVIPEVVRWQTPIAHMRRTALEDVEFRGKQI 324 Query: 398 PAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAE 457 G V ++ S R+ + RP + I R HH+ FGFG+ +CLG RLAE Sbjct: 325 RKGDKVVMWYLSGNRDDEVIDRPMDF-------IADRPRARHHLSFGFGIHRCLGNRLAE 377 Query: 458 AEMLLLLHHVLKHF 471 ++ +L + + + Sbjct: 378 LQLKILWEEMCERY 391 >4TRI-A nrPDB Length = 407 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 30/111 (27%), Positives = 51/111 (45%), Gaps = 8/111 (7%) Query: 361 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP 420 ++ LL A++E LR + R +++D V + AG + + S + ++F P Sbjct: 262 DVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDP 321 Query: 421 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 + + R + HV FGFG CLG +LA E+ L+ VL+ Sbjct: 322 DNFRIDRNPN--------SHVAFGFGTHFCLGNQLARLELRLMTERVLRRL 364 >3NC3-A nrPDB Length = 441 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 53/107 (49%), Gaps = 8/107 (7%) Query: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 A+ ETLR P + R +S D V+ I T+V + + R+ F +P+ +N R Sbjct: 305 AIAETLRYKPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHR 364 Query: 428 W-LDIR----GSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 L I+ G+ R H+ FG G+ C+G A+ E+ ++ + VL Sbjct: 365 EDLGIKSAFSGAAR---HLAFGSGIHNCVGTAFAKNEIEIVANIVLD 408 >4PWV-A nrPDB Length = 446 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 43/190 (22%), Positives = 77/190 (40%), Gaps = 26/190 (13%) Query: 299 LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKA 358 L+ E I N L G +T+ ++ ++ + PD ++LR + Sbjct: 255 LTEEVIVLNCYSLILGGDETSRLSMIDSVQTFTQYPDQWELLRDGKVT------------ 302 Query: 359 TTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFP 418 L +A +E LR + R +D+ L I AG +V ++ S R+ +F Sbjct: 303 ------LESATEEVLRWATPAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFA 356 Query: 419 RPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQ 478 P ++ R + H+ FG+G CLG L AE+ LL + + +T Sbjct: 357 DPYAFDLNRSPN--------KHITFGYGPHFCLGAYLGRAEVHALLDALRTYTTGFEITG 408 Query: 479 EDIKMVYSFI 488 E ++ +F+ Sbjct: 409 EPQRIHSNFL 418 >6GII-A nrPDB Length = 479 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 31/127 (24%), Positives = 57/127 (44%), Gaps = 7/127 (5%) Query: 364 LLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERY 423 L+ AA +E LR R + ++ ++ +P G + + + S ++A F PE Sbjct: 340 LIPAAAEECLRYNGPVAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPE-- 397 Query: 424 NPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKM 483 + DI G H+ FG+G QCLGR L EM +++ + + L ++ Sbjct: 398 ----FFDI-GRSNASEHLNFGYGAHQCLGRNLGRMEMQIMIEELSRRLPHMRLAEQRFDY 452 Query: 484 VYSFILR 490 +++ R Sbjct: 453 LHNVSFR 459 >5L94-A nrPDB Length = 410 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 32/111 (28%), Positives = 51/111 (45%), Gaps = 8/111 (7%) Query: 361 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP 420 E LL + ++E LR L R+V D+ L + AG V ++ S R+A F P Sbjct: 271 EKELLPSGIEEVLRYRSPVQALHRIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDP 330 Query: 421 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 E + R ++ H+ FG G+ CLG LA E ++L ++ + Sbjct: 331 EVFKIDRKPNV--------HMAFGRGIHFCLGAPLARIEAKIMLAELIDRY 373 >2Z36-A nrPDB Length = 413 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 31/105 (29%), Positives = 51/105 (48%), Gaps = 9/105 (8%) Query: 368 ALKETLRLYPVGLFL-ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQ 426 A++E LR + + + R+ + D+ + I AG V V + S + A+F P Sbjct: 281 AVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPA----- 335 Query: 427 RWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 LD+ R HH+ FGFG QCLG+ LA E+ ++ + + Sbjct: 336 -VLDVERGAR--HHLAFGFGPHQCLGQNLARMELQIVFDTLFRRI 377 >3OFT-A nrPDB Length = 396 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 80/206 (38%), Gaps = 44/206 (21%) Query: 265 QYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLL 324 Q GD+ +I E RP +++ + L G +DT A + Sbjct: 200 QPGDDLFSRILSEPVGGRP---------------WTVDEARRMCRNLLFGGLDTVAAMIG 244 Query: 325 MTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLER 384 M LAR+P+ Q++LR E P L+ AA E +R YP + + R Sbjct: 245 MVALHLARHPEDQRLLR-----------ERPD-------LIPAAADELMRRYPT-VAVSR 285 Query: 385 VVSSDLVLQNYHIPAGTLVQV--FLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVP 442 +D+ I G LV + L++L + A F PE R L H Sbjct: 286 NAVADVDADGVTIRKGDLVYLPSVLHNL--DPASFEAPEEVRFDRGL------APIRHTT 337 Query: 443 FGFGMRQCLGRRLAEAEMLLLLHHVL 468 G G +C+G LA E+++ L L Sbjct: 338 MGVGAHRCVGAGLARMEVIVFLREWL 363 >3L4D-A nrPDB Length = 453 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 27/116 (23%), Positives = 52/116 (44%), Gaps = 4/116 (3%) Query: 361 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP 420 E+P +E++R P + L R V + + Y +P G ++ ++ FP P Sbjct: 310 EMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNP 369 Query: 421 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL 476 +NP+R + + FG G+ +C+G + ++ +L VL+ + E L Sbjct: 370 REWNPERNMKLVDGA----FCGFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFELL 421 >5LIV-A nrPDB Length = 450 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 57/252 (22%), Positives = 104/252 (41%), Gaps = 44/252 (17%) Query: 228 EVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYT 287 E + ++ ++ M R L R P E A+ +++ ++ + Sbjct: 196 EKLHETDERVRAMLRGLVRMHDPAAVAESQRAYGETLGLITEVVERESRDTSDT------ 249 Query: 288 GIVAELL--LKAE--LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE 343 ++ E+L LKAE ++EA + + L G +TT++ + T+ L +PD +RQ+ Sbjct: 250 -LLGEILRTLKAEHMDTIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQD 308 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLV 403 LL AA++E +R P + R+V D+ L + + AGT+V Sbjct: 309 P------------------SLLPAAIEEGMRWCPSSFGVLRMVERDVRLDDQALSAGTVV 350 Query: 404 QVFLYSLGRNAALFPRPERYNPQR----WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAE 459 + + + +P PE Y+ R ++ G G +F C+G LA E Sbjct: 351 CLAGIAGNYDETAYPSPEVYDIDRKPLPAANVFGGGAHF-----------CVGAPLARME 399 Query: 460 MLLLLHHVLKHF 471 + L +L F Sbjct: 400 ARVGLQALLARF 411 >6F88-A nrPDB Length = 400 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 49/191 (25%), Positives = 84/191 (43%), Gaps = 37/191 (19%) Query: 289 IVAELL--LKAE--LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQES 344 ++ E+L LKAE ++EA + + L G +TT++ + T+ L +PD +RQ+ Sbjct: 200 LLGEILRTLKAEHMDTIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDP 259 Query: 345 LAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQ 404 LL AA++E +R P + R+V D+ L + + AGT+V Sbjct: 260 ------------------SLLPAAIEEGMRWCPSNFGVLRMVERDVRLDDQALSAGTVVC 301 Query: 405 VFLYSLGRNAALFPRPERYNPQR----WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEM 460 + + + +P PE Y+ R ++ G G +F C+G LA E Sbjct: 302 LAGIAGNYDETAYPSPEVYDIDRKPLPAANVFGGGAHF-----------CVGAPLARMEA 350 Query: 461 LLLLHHVLKHF 471 + L +L F Sbjct: 351 RVGLQALLARF 361 >5D3U-A nrPDB Length = 427 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 31/102 (30%), Positives = 46/102 (45%), Gaps = 7/102 (6%) Query: 370 KETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWL 429 E LR F RV + D+ + I AG + +FL S R+A +F RP ++ L Sbjct: 305 NEVLRYNASNQFTWRVAAKDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDFD----L 360 Query: 430 DIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 D S R H+ FG G+ CL +L ++ +L F Sbjct: 361 DRPNSAR---HLSFGQGVHACLAAQLISLQLKWFYVALLNRF 399 >2FR7-A nrPDB Length = 412 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 46/155 (29%), Positives = 68/155 (43%), Gaps = 31/155 (20%) Query: 311 LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALK 370 L+AG +DTT + ++ LAR PD LR + L R A + Sbjct: 249 LSAG-LDTTVNGIAAAVYCLARFPDEFARLRADP------------------SLARNAFE 289 Query: 371 ETLRL-YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWL 429 E +R PV F R + D+ L I G V +FL S R+ + P+RY+ R Sbjct: 290 EAVRFESPVQTFF-RTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRYDITR-- 346 Query: 430 DIRGSGRNFHHVPFGFGMRQCLGRRLA--EAEMLL 462 + HV FG G+ C+G+ +A E E++L Sbjct: 347 ------KTSGHVGFGSGVHMCVGQLVARLEGEVVL 375 >6CR2-A nrPDB Length = 477 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 39/150 (26%), Positives = 61/150 (40%), Gaps = 20/150 (13%) Query: 327 LFELARNPDVQQILRQESLAAAAS-ISEHPQKATTELPLLRAALKETLRLYPVGLFLERV 385 + LA PD+ + L QE + S + +L L +KETLRL+ + R Sbjct: 274 VLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRA 333 Query: 386 VSSDLVLQ--NYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLD------------- 430 V + + + +Y IP V R+ FP P +NP RW + Sbjct: 334 VKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVD 393 Query: 431 ----IRGSGRNFHHVPFGFGMRQCLGRRLA 456 + G N ++PFG G +C+G + A Sbjct: 394 YGYGLVSKGTNSPYLPFGAGRHRCIGEQFA 423 >4YZR-A nrPDB Length = 405 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 32/117 (27%), Positives = 51/117 (43%), Gaps = 9/117 (7%) Query: 356 QKATTELPLLRAALKETLRLY-PVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNA 414 +K + ++ A++E LR PV + R D + + I G ++ + + S R+ Sbjct: 265 EKLKQQPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDP 324 Query: 415 ALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 F PE N R + H+ FGFG+ CLG LA E + +LK F Sbjct: 325 NFFENPEILNINRSPN--------RHISFGFGIHFCLGAPLARLEGHIAFKALLKRF 373 >5FSA-A nrPDB Length = 490 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 39/178 (21%), Positives = 71/178 (39%), Gaps = 27/178 (15%) Query: 314 GSVDTTAFPLLMTLFELARNPDVQQILRQESLA----AAASISEHPQKATTELPLLRAAL 369 G T+A L L P +Q ++ QE + +++ + +LP + + Sbjct: 265 GGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTI 324 Query: 370 KETLRLY-PVGLFLERVVSSDLVLQ-NYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 KETLR++ P+ +V + + + NY +P G V V + F PE ++P R Sbjct: 325 KETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTR 384 Query: 428 W---------------------LDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLL 464 W G + ++PFG G +C+G + A ++ +L Sbjct: 385 WDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 442 >2IAG-A nrPDB Length = 482 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/145 (27%), Positives = 70/145 (48%), Gaps = 18/145 (12%) Query: 355 PQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVL-----QNYHIPAGTLVQVFLY- 408 PQK P+L + L E+LRL F+ R V DL + + +++ G + +F + Sbjct: 309 PQKVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFL 367 Query: 409 SLGRNAALFPRPERYNPQRWLDIRGS-GRNFH---------HVPFGFGMRQCLGRRLAEA 458 S R+ ++ PE + R+L+ GS ++F+ ++P+G G CLGR A Sbjct: 368 SPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVN 427 Query: 459 EMLLLLHHVLKHFLVETLTQEDIKM 483 + + VL H +E L D+++ Sbjct: 428 SIKQFVFLVLVHLDLE-LINADVEI 451 >1CPT-A nrPDB Length = 428 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 45/194 (23%), Positives = 79/194 (40%), Gaps = 28/194 (14%) Query: 304 IKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELP 363 I A + + DTT+ + L+RNP E LA A S + Sbjct: 257 INAYYVAIATAGHDTTSSSSGGAIIGLSRNP--------EQLALAKS----------DPA 298 Query: 364 LLRAALKETLR-LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPER 422 L+ + E +R PV F+ R +D ++ +I G + + S R+ +F P+ Sbjct: 299 LIPRLVDEAVRWTAPVKSFM-RTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDE 357 Query: 423 YNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIK 482 ++ R+ + H+ FG+G CLG+ LA+ EM + +L L+ Sbjct: 358 FDITRFPN--------RHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPPRL 409 Query: 483 MVYSFILRPGTSPL 496 + +F+ P P+ Sbjct: 410 VATNFVGGPKNVPI 423 >6G5O-A nrPDB Length = 399 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 57/247 (23%), Positives = 102/247 (41%), Gaps = 37/247 (14%) Query: 226 ALEVMFKSTVQLMFMPRSLSR-WIS--PKVWKEHFEAWD-----CIFQYGDNCIQKIYQE 277 AL + ++ L+ P S S WIS V++ EA D ++ Y D I + + Sbjct: 127 ALRLQSRALTLLLNTPFSESETWISWGTHVFRSEGEALDGDKANILYHYIDEQIDRASEN 186 Query: 278 LAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQ 337 + Y+ ++ +L+ E +K + AG DT + ++ LA +P+ Sbjct: 187 PGDDM---YSVLLNSEFEGRKLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEAL 243 Query: 338 QILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHI 397 + LR+E P+ + A++E +R + + RVV+ D + + + Sbjct: 244 ERLRKE-----------PE-------ITGRAVEEMIRYFSPLTQMGRVVTEDTHVCEHAV 285 Query: 398 PAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAE 457 A + + + S R+AA+F P R ++ HV FGF CLG A Sbjct: 286 KADSRISLCWASANRDAAVFENPNEIVLDRKVN--------PHVGFGFSHHNCLGATHAR 337 Query: 458 AEMLLLL 464 + +LL Sbjct: 338 QILKILL 344 >5XJN-A nrPDB Length = 455 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 34/120 (28%), Positives = 52/120 (43%), Gaps = 10/120 (8%) Query: 353 EHPQK--ATTELP-LLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYS 409 +HP++ A E P L+ AA+ E LR + R D + I G V + + S Sbjct: 310 DHPEQWQAILENPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGS 369 Query: 410 LGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 R+ A F E ++ R H+ FGFG+ CLG LA+ + + L V + Sbjct: 370 ANRDEARFENGEEFDISR-------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEVTR 422 >5H1Z-A nrPDB Length = 407 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 30/121 (24%), Positives = 57/121 (47%), Gaps = 7/121 (5%) Query: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 ++E +R + R + D L+ I AG + ++ S R+ ++F N R Sbjct: 281 TVQEIIRWQTPLAHMRRTATVDSELEGQQIKAGDKLALWYISANRDESVFE-----NADR 335 Query: 428 WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSF 487 + R + R H+ FG G+ +C+G RLAE ++ +LL + K + + E ++ F Sbjct: 336 IIVDRPNAR--RHLAFGHGIHRCVGARLAELQIAVLLEEMAKRRMRVNVLGEPERVAACF 393 Query: 488 I 488 + Sbjct: 394 V 394 >5GWE-A nrPDB Length = 405 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 35/120 (29%), Positives = 54/120 (45%), Gaps = 10/120 (8%) Query: 353 EHPQK--ATTELP-LLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYS 409 +HP++ A E P L+ AA+ E LR + R D + I G V + + S Sbjct: 260 DHPEQWQAILENPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGS 319 Query: 410 LGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 R+ A F E ++ R + R H+ FGFG+ CLG LA+ + + L V + Sbjct: 320 ANRDEARFENGEEFDISR-----ANARE--HLSFGFGIHYCLGNMLAKLQAKICLEEVTR 372 >5M0P-A nrPDB Length = 428 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 32/125 (25%), Positives = 51/125 (40%), Gaps = 13/125 (10%) Query: 358 ATTELPLLRAALK-----------ETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVF 406 A E P+ R +K E R YP FL D+ Q IPAG + + Sbjct: 266 AMNENPITREKIKSEPDYAYKFAQEVRRYYPFVPFLPGKAKVDIDFQGVTIPAGVGLALD 325 Query: 407 LYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHH 466 +Y + +L+ P + P+R+ GS F +P G G R E ++++ Sbjct: 326 VYGTTHDESLWDDPNEFRPERFETWDGS--PFDLIPQGGGDYWTNHRCAGEWITVIIMEE 383 Query: 467 VLKHF 471 +K+F Sbjct: 384 TMKYF 388 >5XW2-A nrPDB Length = 419 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 36/123 (29%), Positives = 56/123 (45%), Gaps = 10/123 (8%) Query: 350 SISEHPQKATTELPLLRAALKETLR-LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLY 408 S E + + L+ L+E++R L PV R + D+ + + A +V V+ Sbjct: 274 SYPEQAARVRADRSLIPGLLEESMRFLSPVAATY-RATTRDVEVAGQRLSADQMVMVWFG 332 Query: 409 SLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468 + R+A F PE ++ R G N H+ FG G+ CLG LA E + L H+L Sbjct: 333 AANRDARQFAEPELFDMTR-------GPN-PHLGFGRGIHFCLGGPLARMEGRVALDHLL 384 Query: 469 KHF 471 F Sbjct: 385 DRF 387 >6CVC-A nrPDB Length = 433 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 44/215 (20%), Positives = 87/215 (40%), Gaps = 27/215 (12%) Query: 278 LAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQ 337 LA +R ++ G + L++AE+ E + ++ + + L +A N + Sbjct: 230 LADDRRVNHHGDLTTSLVEAEVDGERLSSSEIAM------------FFILLVVAGNETTR 277 Query: 338 QILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHI 397 + LA + E + + L A++E +R +++ R +S D+ L+ + Sbjct: 278 NAISHGMLALSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLSQDVDLRGTKM 337 Query: 398 PAGTLVQVFLYSLGRNAALFPRPERY----NPQRWLDIRGSGRNFHHVPFGFGMRQCLGR 453 AG V ++ S R+ F P + NP + G G +F CLG Sbjct: 338 AAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGGGAHF-----------CLGA 386 Query: 454 RLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFI 488 LA E+ ++ + + T+E +++ FI Sbjct: 387 NLARREIRVVFDELRRQMPDVVATEEPARLLSQFI 421 >2ZQJ-A nrPDB Length = 417 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 31/62 (50%) Query: 369 LKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRW 428 ++E R YP G FL +V D V N GT V + LY + L+ P+ + P+R+ Sbjct: 280 VQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPERF 339 Query: 429 LD 430 + Sbjct: 340 AE 341 >6FYJ-A nrPDB Length = 421 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 28/111 (25%), Positives = 48/111 (43%), Gaps = 3/111 (2%) Query: 369 LKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRW 428 ++E R YP F+ +V D + Y GTL + LY + ++ P+ ++P R+ Sbjct: 284 VQEVRRFYPFFPFVVALVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRF 343 Query: 429 LDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQE 479 GS F +P G G +G R A + + + V +L + E Sbjct: 344 AKWEGSP--FSFIPQG-GGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYE 391 >2Y5N-A nrPDB Length = 417 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 32/110 (29%), Positives = 49/110 (44%), Gaps = 10/110 (9%) Query: 364 LLRAALKETLRLYP--VGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPE 421 L+ +A++E R P VG R D+ L+ I AG V + R+ A FP + Sbjct: 286 LIPSAVEELTRWVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDAD 345 Query: 422 RYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 R + R + H+ FG G+ CLG LA E+ + L +L+ Sbjct: 346 RIDVDRTPN--------QHLGFGHGVHHCLGAPLARVELQVALEVLLQRL 387 >5HDI-A nrPDB Length = 404 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 49/175 (28%), Positives = 76/175 (43%), Gaps = 27/175 (15%) Query: 297 AELSLEAIKANSMELT--AGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEH 354 A L+ + A M +T A ++TA L ++ LA PD+QQ +R + Sbjct: 225 ASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRA-----------N 273 Query: 355 PQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNA 414 P+ LL A ++ETLR P R V + L +PA + + + + R+ Sbjct: 274 PE-------LLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDP 326 Query: 415 ALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 A F P + LD R G+ H+ FG G C+G LA E ++L +L Sbjct: 327 AQFEAPGEFR----LD-RAGGKG--HISFGKGAHFCVGAALARLEARIVLRLLLD 374 >5HIW-A nrPDB Length = 398 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 47/183 (25%), Positives = 78/183 (42%), Gaps = 30/183 (16%) Query: 289 IVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAA 348 IVAE L +EA + + L GS +TT++ L L L +PD LRQ+ Sbjct: 207 IVAEGLG----GVEACEGVVLTLILGSYETTSWMLANLLVALLAHPDAMNQLRQQP---- 258 Query: 349 ASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLY 408 LL A++E+ R + R V + + + AGT++ + L Sbjct: 259 --------------SLLPQAIEESTRWCSSAAGIVRFVEREATIGGETLAAGTILYLSLI 304 Query: 409 SLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468 + + ++PRPE ++ R R + FG G+ C+G LA E + + +L Sbjct: 305 ARHYDEEIYPRPETFDIHR--------RPVGMLNFGGGLHYCVGAPLARMEARVGVSLLL 356 Query: 469 KHF 471 + F Sbjct: 357 ERF 359 >2VZM-A nrPDB Length = 436 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 35/110 (31%), Positives = 50/110 (45%), Gaps = 9/110 (8%) Query: 361 ELPLLRAALKETLRLY-PVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPR 419 ++ LL A++E LR PV R + L IPAG V V L R FP Sbjct: 292 DMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPD 351 Query: 420 PERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 P R++ +R D G H+ FG G+ C+G LA E + + +L+ Sbjct: 352 PHRFDIRR--DTAG------HLAFGHGIHFCIGAPLARLEARIAVRALLE 393 >6GK6-A nrPDB Length = 411 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 35/124 (28%), Positives = 54/124 (43%), Gaps = 9/124 (7%) Query: 364 LLRAALKETLRLY-PVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPER 422 L+ +A++E LR P L R D+ L +PAG V L + R+ FP P+R Sbjct: 275 LVGSAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDR 334 Query: 423 YNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIK 482 ++ R + H+ FG G+ CLG LA E + +L+ L Sbjct: 335 FDIGRSPN--------RHIGFGGGIHFCLGAMLARIEAAIAFSTLLRRLPRIELATSTRD 386 Query: 483 MVYS 486 +V+S Sbjct: 387 IVWS 390 >3EJB-B nrPDB Length = 404 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 54/232 (23%), Positives = 98/232 (42%), Gaps = 40/232 (17%) Query: 275 YQELAFNRPQHYTGIVAELLLKA----ELSLEAIKANSMELTAGSVDTTAFPLLMTLFEL 330 ++EL R +H + +LLK +L+ E + + L +TT + ++ L Sbjct: 191 FKELIQKRKRHPQQDMISMLLKGREKDKLTEEEAASTCILLAIAGHETTVNLISNSVLCL 250 Query: 331 ARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDL 390 ++P +Q+L+ + E+P L+ A++E LR RV S D+ Sbjct: 251 LQHP--EQLLK---------LRENPD-------LIGTAVEECLRYESPTQMTARVASEDI 292 Query: 391 VLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQC 450 + I G V + L + R+ ++F P+ ++ R + H+ FG G C Sbjct: 293 DICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPN--------PHLSFGHGHHVC 344 Query: 451 LGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAI 502 LG LA E + ++ +L+ + +L D + Y PL FRA+ Sbjct: 345 LGSSLARLEAQIAINTLLQR--MPSLNLADFEWRY--------RPLFGFRAL 386 >4MM0-A nrPDB Length = 399 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 49/181 (27%), Positives = 76/181 (41%), Gaps = 31/181 (17%) Query: 300 SLEAIKANSMELTAGSVDTTAFPLLMTLFELARN---PDVQQILRQESLAAAASISEHPQ 356 +L A A ELT V + + LL+ +E A N V +LR A + P Sbjct: 210 ALVATAAEDNELTDHDVRSLSLILLLAGYEPASNQLGSSVLTLLRFPD--RLAELRRDPG 267 Query: 357 KATTELPLLRAALKETLRLYPVG---LFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRN 413 LL +A++E +R P G LF RV D+ + + HIPA + V + Sbjct: 268 -------LLPSAVEELMRYAPAGDGALF--RVTLEDVTIGDTHIPANSAVLASTQA---- 314 Query: 414 AALFPRPERYNPQRWLDIRG---SGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKH 470 ++P+R+ D G + H G G+ CLG LA E+ + + +L+ Sbjct: 315 -------ANWDPRRFDDPTGLRLDRPDNQHTALGHGIHFCLGAALARVELQVAIGALLRR 367 Query: 471 F 471 F Sbjct: 368 F 368 >6G71-A nrPDB Length = 405 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 49/216 (22%), Positives = 98/216 (45%), Gaps = 39/216 (18%) Query: 249 SPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE--LSLEAIKA 306 P VW + ++ D I D ++++ Q ++ + +++ LL A+ + LE+I++ Sbjct: 176 DPDVWAKAKQSSDEI----DAALEEMIQ---WHSGRPGDSLLSYLLRSADYQMPLESIRS 228 Query: 307 N-SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLL 365 N M + G + + TL L+ + ++ +LR L A Sbjct: 229 NIKMTIGGGLNEPRDVLGVSTLALLSSSKQLELVLRDPKLWGAV---------------- 272 Query: 366 RAALKETLR-LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYN 424 +E++R + P+G+ + V D L Y IP G + + + S R+ +++ P+R++ Sbjct: 273 ---FEESIRWVAPIGMVPRQTVV-DTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFD 328 Query: 425 PQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEM 460 + RGS H+ FG G+ CLG A +++ Sbjct: 329 IE-----RGSE---AHLAFGKGVHVCLGAWAARSQV 356 >4OQR-A nrPDB Length = 457 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 30/102 (29%), Positives = 47/102 (46%), Gaps = 9/102 (8%) Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 R D+ L+ I G V + L ++ R+ +F P+ R +D R H F Sbjct: 328 RAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR-VDAR------KHAAF 380 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHF--LVETLTQEDIKM 483 G G+ QCLG++LA EM + + F L + E+IK+ Sbjct: 381 GGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKL 422 >1Z8P-A nrPDB Length = 404 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 35/125 (28%), Positives = 56/125 (44%), Gaps = 10/125 (8%) Query: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 A++E LR R + ++ + IP + V V + R+ FP P R++ R Sbjct: 277 AVEEILRYIAPPETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFDVTR 336 Query: 428 WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF--LVETLTQEDIKMVY 485 D RG H+ FG G+ C+GR LA+ E + L + F L + +D+ Sbjct: 337 --DTRG------HLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADDVVWRR 388 Query: 486 SFILR 490 S +LR Sbjct: 389 SLLLR 393 >1F4U-A nrPDB Length = 368 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 32/115 (27%), Positives = 51/115 (44%), Gaps = 9/115 (7%) Query: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 A++E LR P + R + L + I G V+V++ S R+ +F E++ P R Sbjct: 243 AIEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIPDR 302 Query: 428 WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFL-VETLTQEDI 481 + H+ FG G+ CLG LA E + + K F +E L E + Sbjct: 303 NPN--------PHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFRHIEILDTEKV 349 >5HH3-A nrPDB Length = 397 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/75 (37%), Positives = 39/75 (52%), Gaps = 11/75 (14%) Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPE-RYNPQRWLDIRGSGRNFHHVP 442 RV + D+ + ++ I AG V L + R FPRPE R++ R +R H+ Sbjct: 291 RVATDDVRIGDHLIKAGDTVTCSLLAANRRN--FPRPEDRFDITR---VRP-----EHLA 340 Query: 443 FGFGMRQCLGRRLAE 457 FG G+ CLGR LAE Sbjct: 341 FGHGIHHCLGRSLAE 355 >4OQS-A nrPDB Length = 433 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 30/102 (29%), Positives = 47/102 (46%), Gaps = 9/102 (8%) Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 R D+ L+ I G V + L ++ R+ +F P+ R +D R H F Sbjct: 289 RAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR-VDAR------KHAAF 341 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHF--LVETLTQEDIKM 483 G G+ QCLG++LA EM + + F L + E+IK+ Sbjct: 342 GGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKL 383 >4Z5P-A nrPDB Length = 400 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 10/110 (9%) Query: 364 LLRAALKETLRLYPVGLFL--ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPE 421 LL A++E LR P+G + R+ D+ L + AG V + R+ F P+ Sbjct: 269 LLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPD 328 Query: 422 RYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 R + R H+ FG G CLG +LA E+ + + +L+ F Sbjct: 329 RLDITR--------EKNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERF 370 >4DO1-A nrPDB Length = 410 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 44/155 (28%), Positives = 67/155 (43%), Gaps = 31/155 (20%) Query: 311 LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALK 370 L+AG +DTT + ++ LAR P Q LR + L R A + Sbjct: 247 LSAG-LDTTVNGIGAAVYCLARFPGELQRLRSDPT------------------LARNAFE 287 Query: 371 ETLRL-YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWL 429 E +R PV F R + ++ L I G V +FL S R+ + P+ Y+ R Sbjct: 288 EAVRFESPVQTFF-RTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITR-- 344 Query: 430 DIRGSGRNFHHVPFGFGMRQCLGRRLA--EAEMLL 462 + HV FG G+ C+G+ +A E E++L Sbjct: 345 ------KTSGHVGFGSGVHMCVGQLVARLEGEVML 373 >4YT3-A nrPDB Length = 410 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 60/248 (24%), Positives = 95/248 (38%), Gaps = 39/248 (15%) Query: 229 VMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTG 288 ++FK V +F+P R +V K A +QY +Y + R Sbjct: 163 LLFKKWVDTLFLP--FDREKQEEVDKLKQVAAKEYYQY-------LYPIVVQKRLNPADD 213 Query: 289 IVAELLLKAELSLEAIKAN-----SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE 343 I+++LL K+E+ E + +M + V+TT+ L + + L + Sbjct: 214 IISDLL-KSEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDD--------- 263 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLV 403 E Q+ L L+ A++E LR + L+R V D L + G V Sbjct: 264 --------KEVYQELHENLDLVPQAVEEMLRFRFNLIKLDRTVKEDNDLLGVELKEGDSV 315 Query: 404 QVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLL 463 V++ + + +F P N R N H+ FG G CLG LA E + Sbjct: 316 VVWMSAANMDEEMFEDPFTLNIHR-------PNNKKHLTFGNGPHFCLGAPLARLEAKIA 368 Query: 464 LHHVLKHF 471 L LK F Sbjct: 369 LTAFLKKF 376 >1Q5D-A nrPDB Length = 419 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 45/188 (23%), Positives = 77/188 (40%), Gaps = 32/188 (17%) Query: 290 VAELLLKAE-----LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQES 344 V +LL+AE LS + + A + A DTT + + + L R+P+ ++++ E Sbjct: 225 VLTMLLQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAEP 284 Query: 345 LAAAASISEHPQKATTELPLLRAALKETLRLYPV-GLFLERVVSSDLVLQNYHIPAGTLV 403 L+R AL E LR + + R DL I G +V Sbjct: 285 ------------------GLMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMV 326 Query: 404 QVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLL 463 + + S R+ +F RP+ ++ +R D S + +G G C G LA E + Sbjct: 327 FLLIPSALRDGTVFSRPDVFDVRR--DTSAS------LAYGRGPHVCPGVSLARLEAEIA 378 Query: 464 LHHVLKHF 471 + + + F Sbjct: 379 VGTIFRRF 386 >2WM5-A nrPDB Length = 435 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 31/133 (23%), Positives = 57/133 (42%), Gaps = 15/133 (11%) Query: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERY---- 423 A++E +R +++ R ++ D+ L+ + AG V ++ S R+ + F P + Sbjct: 311 AVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLAR 370 Query: 424 NPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKM 483 NP L G G +F CLG LA E+ + + + T+E ++ Sbjct: 371 NPNPHLGFGGGGAHF-----------CLGANLARREIRVAFDELRRQMPDVVATEEPARL 419 Query: 484 VYSFILRPGTSPL 496 + FI T P+ Sbjct: 420 LSQFIHGIKTLPV 432 >4XE3-A nrPDB Length = 407 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 32/111 (28%), Positives = 51/111 (45%), Gaps = 12/111 (10%) Query: 364 LLRAALKETLRLYPV---GLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP 420 L+ AA++E LR P+ G F+ RV + D+ L + AG V S R+ +F Sbjct: 276 LVPAAVEEMLRYTPLVSAGSFV-RVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHA 334 Query: 421 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 + + R RN H+ FG G C+G +L E+ L +++ F Sbjct: 335 DELDFHRE-------RN-PHIAFGHGAHHCIGAQLGRLELQEALSALVRRF 377 >3WVS-A nrPDB Length = 401 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 32/121 (26%), Positives = 52/121 (42%), Gaps = 10/121 (8%) Query: 353 EHPQKATTELPLLRAALKETLRLYPVGL--FLERVVSSDLVLQNYHIPAGTLVQVFLYSL 410 +H ++ + L+ +A++E R P+G R D+ + + AG V V L + Sbjct: 262 QHWKRLLDDPELIPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAA 321 Query: 411 GRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKH 470 R+ F PE R + HH+ FG G+ CLG LA E+ L +L+ Sbjct: 322 NRDGLRFEDPEEIKLDR--------PSNHHIGFGHGIHHCLGAPLARLELQEALRALLER 373 Query: 471 F 471 Sbjct: 374 L 374 >5Y1I-A nrPDB Length = 403 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 44/178 (24%), Positives = 76/178 (42%), Gaps = 27/178 (15%) Query: 297 AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ 356 E++ + M L +TTA + + L NP E LA S+ P+ Sbjct: 220 GEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENP--------EQLAEVRD-SDDPK 270 Query: 357 KATTELPLLRAALKETLRLYPVGL-FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAA 415 ++ ++E LR + + R+ + D+ + I AG + L + + Sbjct: 271 -------VIVNTVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPD 323 Query: 416 LFPR-PERYNPQRWLDI-RGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 L+P P+R LDI R + R H+ FG+G+ QCLG LA E+ ++ +L+ Sbjct: 324 LYPEAPDR------LDIHRANAR--RHLAFGYGVHQCLGATLARVELQIVYSTLLRRI 373 >1LG9-A nrPDB Length = 398 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 36/88 (40%), Gaps = 8/88 (9%) Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 R+ DL L I G V L + R+ AL P +R + R HV F Sbjct: 289 RIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTR--------EPIPHVAF 340 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 G G+ CLG LA E+ + + + F Sbjct: 341 GHGVHHCLGAALARLELRTVFTELWRRF 368 >5CJE-A nrPDB Length = 393 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 33/120 (27%), Positives = 51/120 (42%), Gaps = 12/120 (10%) Query: 354 HPQKATT---ELPLLRAALKETLRLY-PVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYS 409 HP + ++ LL A++E LR PV R + + + I G V + L + Sbjct: 252 HPDQLAALRADMTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDA 311 Query: 410 LGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 GR+ A P P ++ R H+ FG G+ CLG LA E + L +L+ Sbjct: 312 AGRDPARHPDPHVFDIHRA--------PQGHLAFGHGIHYCLGAPLARLEARVALRSLLE 363 >3AWQ-A nrPDB Length = 415 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 29/108 (26%), Positives = 45/108 (41%), Gaps = 3/108 (2%) Query: 369 LKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRW 428 ++E R YP + S D + P G V + LY +AA + P+ + P+R+ Sbjct: 278 VQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQEFRPERF 337 Query: 429 LDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL 476 NF +P G G LG R ++L + V H LV + Sbjct: 338 RAWDEDSFNF--IPQG-GGDHYLGHRCPGEWIVLAIMKVAAHLLVNAM 382 >5EX6-C nrPDB Length = 434 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 59/271 (21%), Positives = 106/271 (39%), Gaps = 33/271 (12%) Query: 207 ERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQ- 265 ERL + S A L L A EV +L+ +PR R + ++ H +A + Sbjct: 161 ERLDEMEREGSPADLIELFADEVPGPVLCELLGVPRD-DRAMFLQLCHRHLDASLSGRRR 219 Query: 266 --YGDNCIQKIYQELAFNRPQHYTGIVAELLLK--AELSLEAIKANSMELTAGSVDTTAF 321 G+ + + +A R G++ ++ + ++ E ++ +++ D + Sbjct: 220 AAAGEAFSRYLVTMVARERKDPGDGLIGMVVAEHGDTVTDEELRGVCVQMMLAGDDNISG 279 Query: 322 PLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTEL-PLLRAALKETLRLYPVGL 380 + + + L RNP+ LR + AA ++ E + T P R A++ Sbjct: 280 MIGLGVLALLRNPEQIAALRGDVPAAERAVDELIRYLTVPYAPTPRTAIE---------- 329 Query: 381 FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHH 440 D + + I AG V L + R+ AL P +R + R H Sbjct: 330 --------DSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTR--------EAVPH 373 Query: 441 VPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 V FG G+ CLG LA E+ + + + F Sbjct: 374 VAFGHGVHHCLGAALARLELRIAYTALWRRF 404 >5NWS-A nrPDB Length = 435 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 40/88 (45%), Gaps = 4/88 (4%) Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 R + DL L + G VQ+ L S + + P+R + R G+ +HV F Sbjct: 320 RYATEDLELAGTPVARGDAVQLVLVSANFDPRHYSDPDRLDITR----HQEGQAENHVGF 375 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 G G+ CLG LA E + L +L+ + Sbjct: 376 GHGIHYCLGATLARQEGEVALARLLETY 403 >3B98-A nrPDB Length = 475 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 45/179 (25%), Positives = 72/179 (40%), Gaps = 21/179 (11%) Query: 311 LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALK 370 +T G+ AF ++ L +P+ + +R+E E QK T P+ + L Sbjct: 264 VTQGNAGPAAFWVMGYLLT---HPEALRAVREEIQGGKHLRLEERQKNT---PVFDSVLW 317 Query: 371 ETLRLYPVGLFLERVVSSDLVL----QNYHIPAGTLVQVFLY-SLGRNAALFPRPERYNP 425 ETLRL L V + Q YH+ G + VF + S + + +PE + Sbjct: 318 ETLRLTAAALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQF 377 Query: 426 QRWLDI----------RGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVE 474 R+L+ G+ + VP+G C GR A + L+ +L F VE Sbjct: 378 DRFLNADRTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVE 436 >3NV6-A nrPDB Length = 452 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 44/174 (25%), Positives = 73/174 (41%), Gaps = 29/174 (16%) Query: 317 DTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLY 376 DT L + LAR+P++ LR + L L+R A +E R + Sbjct: 293 DTVVNFLSFFMIHLARHPELVAELRSDPLK-----------------LMRGA-EEMFRRF 334 Query: 377 PVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRW-LDIRGSG 435 PV + R+V+ D + + G ++ + AL + NP+ W LD S Sbjct: 335 PV-VSEARMVAKDQEYKGVFLKRGDMILL-------PTALHGLDDAANPEPWKLDF--SR 384 Query: 436 RNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFIL 489 R+ H FG G +C G LA E+++ L LK + + + + +S I+ Sbjct: 385 RSISHSTFGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPIYHSGIV 438 >3P3Z-A nrPDB Length = 416 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 40/151 (26%), Positives = 69/151 (45%), Gaps = 27/151 (17%) Query: 311 LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALK 370 L AG +TT L + +++ A++PD Q ++ I E+P+ L A++ Sbjct: 251 LVAG-YETTNHQLALAMYDFAQHPD--QWMK---------IKENPE-------LAPQAVE 291 Query: 371 ETLRLYP-VGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWL 429 E LR P + + RV + D + IP GT V + + R+ +F +R++ + Sbjct: 292 EVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFD----I 347 Query: 430 DIRGSGRNFHHVPFGFGMRQCLGRRLAEAEM 460 ++ R + FG G CLG LA E+ Sbjct: 348 TVK---REAPSIAFGGGPHFCLGTALARLEL 375 >1GWI-A nrPDB Length = 411 Score = 37.0 bits (84), Expect = 0.021, Method: Compositional matrix adjust. Identities = 35/118 (29%), Positives = 53/118 (44%), Gaps = 12/118 (10%) Query: 347 AAASISEHPQKATTELP---LLRAALKETLRL-YPVGLFLERVVSSDLVLQNYHIPAGTL 402 A ++S HP++ L A ++ETLR P L R + D+ + + IPAG Sbjct: 254 AVVNLSTHPEQRALVLSGEAEWSAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDA 313 Query: 403 VQVFLYSLGRNA-ALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAE 459 + V +LGR+ A P +R++ R R H+ FG G C G L+ E Sbjct: 314 LIVSYGALGRDERAHGPTADRFDLTRTSGNR-------HISFGHGPHVCPGAALSRME 364 >5L1U-A nrPDB Length = 401 Score = 35.8 bits (81), Expect = 0.046, Method: Compositional matrix adjust. Identities = 54/240 (22%), Positives = 91/240 (37%), Gaps = 45/240 (18%) Query: 250 PKVWKEHFEAWD-CIFQYGDN---------CIQKIYQELAFNRPQHYTGIVAELLLKAEL 299 P +E F W F DN + + + +A R + I++EL+ + + Sbjct: 159 PLADRERFGQWARGTFDQSDNEHSANTFQQVVDYMLELVARKRVEPGDDILSELIAEKDG 218 Query: 300 SLEAIK----ANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHP 355 +L N++ L +TT + + L RNP VQ+ A ++E P Sbjct: 219 ALSDADIAHLGNAVLLFG--YETTIVRIDLGTLLLLRNP-VQR----------AQLAEDP 265 Query: 356 QKATTELPLLRAALKETLRLYPVG----LFLERVVSSDLVLQNYHIPAGTLVQVFLYSLG 411 A AA++E LRL G + R D+ + I G V + + + Sbjct: 266 GLAP-------AAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAAN 318 Query: 412 RNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 + FP ++ R R H+ FG G R C+GR LA E+ + + + Sbjct: 319 YDDRAFPDGGLFDLTRV-------RPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRL 371 >6FSH-A nrPDB Length = 398 Score = 35.4 bits (80), Expect = 0.052, Method: Compositional matrix adjust. Identities = 57/272 (20%), Positives = 105/272 (38%), Gaps = 35/272 (12%) Query: 207 ERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQ- 265 +RL + + A L L A EV +L+ +PR R + K+ H +A + Q Sbjct: 125 DRLDAMEQAGPPADLIELFADEVPGAVLCELIGVPRD-DRDMFMKLCHGHLDA--SLSQK 181 Query: 266 ----YGDNCIQKIYQELAFNRPQHYTGIVAELLLK--AELSLEAIKANSMELTAGSVDTT 319 GD + + +A R G + ++ + ++ E ++ ++L D Sbjct: 182 RRAALGDKFSRYLLAMIARERKDPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNV 241 Query: 320 AFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVG 379 + + + + L R+P+ LR + +A ++ E L+R T+ P Sbjct: 242 SGMIGLGVLALLRHPEQIAALRGDDQSADRAVDE----------LIRYL---TVPYAPT- 287 Query: 380 LFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFH 439 R D+++ + I G V L R+ AL P +R + R Sbjct: 288 ---PRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRT--------PVP 336 Query: 440 HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 HV FG G+ CLG L ++ + + + F Sbjct: 337 HVAFGHGIHHCLGAALTRLQLRIAYTALWRRF 368 >6DCD-A nrPDB Length = 424 Score = 35.4 bits (80), Expect = 0.053, Method: Compositional matrix adjust. Identities = 47/207 (22%), Positives = 82/207 (39%), Gaps = 34/207 (16%) Query: 301 LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT 360 ++ +++ + AG +TTA L + L PD+Q+ LR+ Sbjct: 240 IDVVRSATFLFAAGQ-ETTAKLLTAAMRVLGDRPDIQRRLRENR---------------- 282 Query: 361 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP 420 L+ ++E+LR+ R+ + I AGT+V V + R+ F P Sbjct: 283 --SLIPNFIEESLRMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDP 340 Query: 421 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQ-- 478 + R ++R H+ F G+ C G LA E + L +L L + + Sbjct: 341 HEFRLDRP-NVR------EHMAFARGVHSCPGGPLARVEGRVSLERILDRMLDIAINEDR 393 Query: 479 ----EDIKMVY--SFILRPGTSPLLTF 499 +D + Y ++ILR T +TF Sbjct: 394 HGPADDRRYTYEPTYILRGLTELHITF 420 >2WIY-A nrPDB Length = 394 Score = 35.0 bits (79), Expect = 0.068, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 58/138 (42%), Gaps = 25/138 (18%) Query: 323 LLMTLFEL-ARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF 381 L+ + EL AR P+V R + A AA I+E +R+ P L Sbjct: 241 LIASGIELFARRPEVFTAFRNDESARAAIINE------------------MVRMDPPQLS 282 Query: 382 LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHV 441 R + D+ + I AG+ ++ + + R+ +F P+ ++ R + RN Sbjct: 283 FLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR---PPAASRNLS-- 337 Query: 442 PFGFGMRQCLGRRLAEAE 459 FG G C G+ ++ AE Sbjct: 338 -FGLGPHSCAGQIISRAE 354 >1EHE-A nrPDB Length = 403 Score = 35.0 bits (79), Expect = 0.070, Method: Compositional matrix adjust. Identities = 30/128 (23%), Positives = 54/128 (42%), Gaps = 12/128 (9%) Query: 349 ASISEHPQKAT--TELPLLRAALKETLRLY--PVGLFLERVVSSDLVLQNYHIPAGTLVQ 404 A++++HP + P L E L Y L ++R D+++ + + A + Sbjct: 253 ATLAQHPDQLAQLKANPSLAPQFVEELCRYHTASALAIKRTAKEDVMIGDKLVRANEGII 312 Query: 405 VFLYSLGRNAALFPRPERYNPQR-WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLL 463 S R+ +F P+ +N R W G FGFG +C+ LA+AE+ + Sbjct: 313 ASNQSANRDEEVFENPDEFNMNRKWPPQDPLG-------FGFGDHRCIAEHLAKAELTTV 365 Query: 464 LHHVLKHF 471 + + F Sbjct: 366 FSTLYQKF 373 >2NZA-A nrPDB Length = 413 Score = 34.7 bits (78), Expect = 0.088, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 45/106 (42%), Gaps = 10/106 (9%) Query: 368 ALKETLRL--YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNP 425 AL E LR + + L R+ D+ + I AG V V + R+ +FP P+R + Sbjct: 280 ALDELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDL 339 Query: 426 QRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 R H+ +G G C G LA + LL+ +L+ Sbjct: 340 DR--------DPNPHLAYGNGHHFCTGAVLARMQTELLVDTLLERL 377 >5XNT-A nrPDB Length = 411 Score = 34.7 bits (78), Expect = 0.092, Method: Compositional matrix adjust. Identities = 59/249 (23%), Positives = 94/249 (37%), Gaps = 41/249 (16%) Query: 229 VMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYG-DNCIQKIYQELAFNRPQHYT 287 ++FK V ++F+P KE E + + Q Q +Y + R Sbjct: 163 LLFKKWVDILFLPFD----------KEKQEEVNELKQVAAKEYYQYLYPIVVQKRLNPAD 212 Query: 288 GIVAELLLKAELSLEAIKAN-----SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQ 342 I+++LL KAE+ E + +M + V+TT+ L + + L + Sbjct: 213 DIISDLL-KAEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDD-------- 263 Query: 343 ESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTL 402 E Q+ L L+ A++E LR + L+R V D L + G Sbjct: 264 ---------KEVYQELHENLDLVPQAVEEMLRYRFNLIKLDRTVKEDNDLLGVELKEGEN 314 Query: 403 VQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLL 462 V V++ + + +F N R N H+ FG G CLG LA E + Sbjct: 315 VVVWMSAANLDEEMFEDAFTLNIHR-------PNNKKHLTFGNGPHFCLGAPLARLEAKI 367 Query: 463 LLHHVLKHF 471 L LK F Sbjct: 368 ALTTFLKKF 376 >6A7J-A nrPDB Length = 411 Score = 33.9 bits (76), Expect = 0.18, Method: Compositional matrix adjust. Identities = 28/107 (26%), Positives = 45/107 (42%), Gaps = 8/107 (7%) Query: 366 RAALKETLRL-YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYN 424 ++ETLR P L R + D+ + + +P G + V +LGR+ E+Y Sbjct: 274 EGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDE------EQYG 327 Query: 425 PQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 P D + H+ FG G C G L+ E + L + + F Sbjct: 328 PTAG-DFDATRTPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERF 373 >2UUQ-A nrPDB Length = 414 Score = 33.9 bits (76), Expect = 0.19, Method: Compositional matrix adjust. Identities = 51/215 (23%), Positives = 82/215 (38%), Gaps = 32/215 (14%) Query: 257 FEAWDCIFQYGDNCIQKIYQELAFNRPQHYT--GIVAELLLKAELSLEAIKANSMELTAG 314 +A + Y I++ E A + H G+ A+ LS I A + + G Sbjct: 194 LDAVGSMMAYFTGLIERRRTEPADDAISHLVAAGVGADGDTAGTLS---ILAFTFTMVTG 250 Query: 315 SVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLR 374 DT L ++ L R PD +++L + P+ + A++E LR Sbjct: 251 GNDTVTGMLGGSMPLLHRRPDQRRLLLDD-----------PEG-------IPDAVEELLR 292 Query: 375 LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRW-LDIRG 433 L L R + D+ + + IPAG V + S R+ +Y P LD+ Sbjct: 293 LTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDE------RQYGPDAAELDVTR 346 Query: 434 SGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468 RN + F G CLG A + + L +L Sbjct: 347 CPRNI--LTFSHGAHHCLGAAAARMQCRVALTELL 379 >5OQL-R nrPDB Length = 313 Score = 33.5 bits (75), Expect = 0.20, Method: Compositional matrix adjust. Identities = 24/97 (24%), Positives = 41/97 (42%), Gaps = 7/97 (7%) Query: 107 HPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVAR 166 H ++ Y H+ G L+N R N + + D P A + +PMVD + Sbjct: 169 HVADIVGPTGAVYAVEFSHRSGRDLINMATRRTNVIPIVEDARKPMAYRMLVPMVDVIFA 228 Query: 167 DFSQALKKKVLQ-NAR------GSLTLDVQPSIFHYT 196 D +Q + +++ NAR G L + ++ S T Sbjct: 229 DVAQPDQARIVGINARLFLKQGGGLLISIKASCIDST 265 >5EX8-A nrPDB Length = 424 Score = 33.5 bits (75), Expect = 0.22, Method: Compositional matrix adjust. Identities = 22/74 (29%), Positives = 33/74 (44%), Gaps = 9/74 (12%) Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 RV + D+ + N + AG V L + R P + + DI + H+ F Sbjct: 318 RVATQDVRIGNQLVKAGDTVTCSLLAANR-------PNYPSAEDEFDI--TREKAEHLAF 368 Query: 444 GFGMRQCLGRRLAE 457 G G+ CLGR +AE Sbjct: 369 GHGIHHCLGRAMAE 382 >4JBT-A nrPDB Length = 410 Score = 32.7 bits (73), Expect = 0.36, Method: Compositional matrix adjust. Identities = 41/175 (23%), Positives = 68/175 (38%), Gaps = 27/175 (15%) Query: 299 LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKA 358 L+ E + N L A +TT +L + L +P+ +++R + Sbjct: 229 LTEEEVIGNLQALVAAGHETTVSLILTAVRALLSHPEQLRLVRDGEIG------------ 276 Query: 359 TTELPLLRAALKETLRLY-PVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALF 417 A++ETLR PV L R + D+ L + IP G V + ++GR+ + Sbjct: 277 ------WETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVH 330 Query: 418 -PRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 + ++ R R H+ FG G C G LA E + L + F Sbjct: 331 GADADDFDITRATAAR-------HISFGHGPHICPGAALARLEAAIALPALFTRF 378 >5OMS-A nrPDB Length = 409 Score = 32.3 bits (72), Expect = 0.52, Method: Compositional matrix adjust. Identities = 28/127 (22%), Positives = 49/127 (38%), Gaps = 9/127 (7%) Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLR-LYPVGLFLERVVSSDLVLQNYHIPAGTL 402 +L S E ++ + L+ A+ E LR P+ R+ + + + +PAGT Sbjct: 259 TLVGLFSRPEQLEEVVDDPTLIPRAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTP 318 Query: 403 VQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLL 462 V + S + + P +Y+ R H+ FG G C G A M + Sbjct: 319 VMLSYGSANHDTGKYEAPSQYDLHR--------PPLPHLAFGAGNHACAGIYFANHVMRI 370 Query: 463 LLHHVLK 469 L + + Sbjct: 371 ALEELFE 377 >5ZR1-C nrPDB Length = 616 Score = 32.0 bits (71), Expect = 0.63, Method: Compositional matrix adjust. Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 9/94 (9%) Query: 244 LSRWISPKVWKE--HFEAWDCIFQ---YGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE 298 L RW + K +K+ HFE D IFQ DN + Q + P Y + + LL E Sbjct: 440 LDRWSACKEYKDRLHFEPIDTIFQELFTLDNRSGLLTQSIF---PS-YKSNIEDNLLSWE 495 Query: 299 LSLEAIKANSMELTAGSVDTTAFPLLMTLFELAR 332 L ++ + + +G +D P+L LF+L R Sbjct: 496 QVLPSLDKENYDTLSGDLDKIMAPVLGQLFKLYR 529 >5DQN-A nrPDB Length = 426 Score = 31.6 bits (70), Expect = 0.92, Method: Compositional matrix adjust. Identities = 52/256 (20%), Positives = 97/256 (37%), Gaps = 38/256 (14%) Query: 226 ALEVMFKSTVQLMFMPRS----LSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFN 281 + E+ ++ +L+ +P+ L RW + E E D + ++A Sbjct: 154 SCELPLQAIAELLGVPQDDRDKLFRWSNEMTAGEDPEYADVDPAMSSFELISYAMKMAEE 213 Query: 282 RPQHYTGIVAELLLKAELSLEAIKANS-----MELTAGSVDTTAFPLLMTLFELARNPDV 336 R + T + L++A++ E + + + L +TT + + A+NPD Sbjct: 214 RAVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNPDQ 273 Query: 337 QQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYH 396 ++ ++ E P+ A E ++R A PV F +R D+ L Sbjct: 274 WELYKK----------ERPETAADE--IVRWAT-------PVSAF-QRTALEDVELGGVQ 313 Query: 397 IPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF-GFGMRQCLGRRL 455 I G V + S + +F P +N R + HV F G G C+G L Sbjct: 314 IKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPN--------PHVGFGGTGAHYCIGANL 365 Query: 456 AEAEMLLLLHHVLKHF 471 A + L+ + + + Sbjct: 366 ARMTINLIFNAIADNM 381 >4FB2-A nrPDB Length = 398 Score = 31.2 bits (69), Expect = 0.96, Method: Compositional matrix adjust. Identities = 36/156 (23%), Positives = 66/156 (42%), Gaps = 27/156 (17%) Query: 314 GSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETL 373 G +D TA L + LA D++ LR+ +A HP+ L+ A+ E L Sbjct: 232 GGIDNTARFLSSVFWRLAW--DIE--LRRRLIA-------HPE-------LIPNAVDELL 273 Query: 374 RLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRG 433 R Y + + R+V+ ++ + + + G ++ R+ + F P+ +R + Sbjct: 274 RFYGPAM-VGRLVTQEVTVGDITMKPGQTAMLWFPIASRDRSAFDSPDNIVIERTPN--- 329 Query: 434 SGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 H+ G G+ +CLG L E + + LK Sbjct: 330 -----RHLSLGHGIHRCLGAHLIRVEARVAITEFLK 360 >2X9P-A nrPDB Length = 404 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 32/118 (27%), Positives = 51/118 (43%), Gaps = 19/118 (16%) Query: 351 ISEHPQK---ATTELPLLRAALKETLRLYPVG--LFLERVVSSDLVLQNYHIPAGTLVQV 405 ++ HP + A + ++ A++E LR G + R S D+ I AG LV Sbjct: 257 LAAHPDQRAAALADPDVMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLV-- 314 Query: 406 FLYSLGR---NAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEM 460 L+ LG + F PE ++ R + H+ FG G+ C+G LA E+ Sbjct: 315 -LFDLGLPNFDERAFTGPEEFDAARTPN--------PHLTFGHGIWHCIGAPLARLEL 363 >6A7I-A nrPDB Length = 411 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 26/106 (24%), Positives = 45/106 (42%), Gaps = 8/106 (7%) Query: 367 AALKETLRL-YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNP 425 ++ETLR P L R + D+ + + +P G + + +LGR+ E+Y P Sbjct: 275 GVIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDE------EQYGP 328 Query: 426 QRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 + + H+ FG G C G L+ E + L + + F Sbjct: 329 TAG-EFDATRTPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERF 373 >4TX3-A nrPDB Length = 404 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 22/88 (25%), Positives = 35/88 (39%), Gaps = 8/88 (9%) Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 R D+++ + I G V L R+ AL P +R + R HV F Sbjct: 295 RTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRT--------PVPHVAF 346 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 G G+ CLG L ++ + + + F Sbjct: 347 GHGIHHCLGAALTRLQLRIAYTALWRRF 374 >3BUJ-A nrPDB Length = 397 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 26/96 (27%), Positives = 42/96 (43%), Gaps = 8/96 (8%) Query: 364 LLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERY 423 LL A++E LR P R + D+ L+ + +V V + R+ + RP+ + Sbjct: 265 LLAQAVEECLRYDPSVQSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDF 324 Query: 424 NPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAE 459 + +R + FG GMR CLG LA + Sbjct: 325 DIER--------DPVPSMSFGAGMRYCLGSYLARTQ 352 >4Z5Q-A nrPDB Length = 423 Score = 29.6 bits (65), Expect = 3.4, Method: Compositional matrix adjust. Identities = 26/96 (27%), Positives = 38/96 (39%), Gaps = 10/96 (10%) Query: 367 AALKETLRLYPVGL--FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYN 424 AA++E LR P R D+ + + G V V ++ R+ +F N Sbjct: 298 AAVEELLRFVPFAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFD-----N 352 Query: 425 PQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEM 460 + R R H+ FG G CLG LA E+ Sbjct: 353 ADEVVIDRADNR---HMVFGHGAHHCLGAHLARVEL 385 >6M7L-A nrPDB Length = 404 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 51/185 (27%), Positives = 77/185 (41%), Gaps = 30/185 (16%) Query: 324 LMTLFELARNPDVQQILRQESLAAAASIS--EHPQKAT--TELPLL-RAALKETLRLYPV 378 L L + N V+Q ES AA ++ EHP++ E P L A++E +R V Sbjct: 234 LAGLCAVVMNSSVEQT---ESCLAAGTLLLLEHPEQFALLRERPELGEQAVEEIVRYLSV 290 Query: 379 GLFLE-RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQ-RWLDIRGSGR 436 L+ R + D+ + I G VF L N R +P DI + + Sbjct: 291 FEGLDPRTATEDVEIGGQVIKKGE--AVFCSLLAAN--------RADPALDGFDI--TRK 338 Query: 437 NFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF--LVETLTQEDIKMVYSFILRPGTS 494 HV FG G+ CLG LA E+ + ++ F L + E+I+ RP +S Sbjct: 339 ESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRFPSLRTAVPAEEIR------FRPPSS 392 Query: 495 PLLTF 499 + T Sbjct: 393 NVFTL 397 >4NQ1-A nrPDB Length = 290 Score = 29.3 bits (64), Expect = 4.0, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 25/46 (54%), Gaps = 2/46 (4%) Query: 62 EHLHLEMHQTFQELG-PIFRYNLGGPRMVCVMLPEDVEKLQQVDSL 106 E L+L Q + PI YN+ G R C MLPE V +L ++ ++ Sbjct: 112 EGLYLHYSHIAQSVAIPIILYNVPG-RTACDMLPETVARLAKISNI 156 >2QBO-A nrPDB Length = 421 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 30/123 (24%), Positives = 49/123 (39%), Gaps = 13/123 (10%) Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGT-- 401 S+ A EH Q+ + AA +E LR + + + R+++SD + G Sbjct: 261 SMEFLAKSPEHRQELIERPERIPAACEELLRRFSL-VADGRILTSDYEFHGVQLKKGDQI 319 Query: 402 LVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEML 461 L+ L L P + + S + H FG G CLG+ LA E++ Sbjct: 320 LLPQMLSGLDERENACP----------MHVDFSRQKVSHTTFGHGSHLCLGQHLARREII 369 Query: 462 LLL 464 + L Sbjct: 370 VTL 372 >3PS7-A nrPDB Length = 292 Score = 28.9 bits (63), Expect = 5.6, Method: Compositional matrix adjust. Identities = 17/44 (38%), Positives = 25/44 (56%), Gaps = 6/44 (13%) Query: 68 MHQTFQELG-----PIFRYNLGGPRMVCVMLPEDVEKLQQVDSL 106 M+Q F+ + P YN+ G R C MLPE VE+L +V ++ Sbjct: 115 MYQHFRHIAEAVAIPQILYNVPG-RTSCDMLPETVERLSKVPNI 157 >5KYO-A nrPDB Length = 430 Score = 28.5 bits (62), Expect = 6.7, Method: Compositional matrix adjust. Identities = 44/178 (24%), Positives = 69/178 (38%), Gaps = 28/178 (15%) Query: 309 MELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAA 368 +++ G +DT L T LA++ LR+ ++AA S L+ A Sbjct: 265 IQVLVGGLDTVVNMLGFTFSHLAKD----HALRR-AIAADPS-------------LIDDA 306 Query: 369 LKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRW 428 L E R +PV + R V D + + AG +V + + A P Sbjct: 307 LLEFFRRFPV-VSSAREVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDP-------- 357 Query: 429 LDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYS 486 L+ R + H FG G C G LA EM ++L + E ++D + YS Sbjct: 358 LEFRLGRKARQHSTFGKGSHTCPGAHLARMEMKVVLREWFAR-IPEFRIEDDAPLRYS 414 >1XDN-A nrPDB Length = 277 Score = 28.5 bits (62), Expect = 6.8, Method: Compositional matrix adjust. Identities = 21/96 (21%), Positives = 38/96 (39%), Gaps = 4/96 (4%) Query: 96 DVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPK--- 152 D+ ++ SLH + + WVA + G G++L+N + R ++ P Sbjct: 15 DLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNENF 74 Query: 153 -AVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLD 187 + A R + LK+K + G L L+ Sbjct: 75 FGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLN 110 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4ZGX-A nrPDB 616 e-176 6M7X-A nrPDB 565 e-161 3N9Z-A nrPDB 500 e-142 3MZS-A nrPDB 496 e-141 3K9V-A nrPDB 411 e-115 2PG7-A nrPDB 344 5e-95 3E6I-A nrPDB 334 5e-92 5W0C-A nrPDB 329 2e-90 4GQS-A nrPDB 323 9e-89 1N6B-A nrPDB 323 1e-88 4H1N-A nrPDB 317 6e-87 5E0E-A nrPDB 314 4e-86 2NNH-A nrPDB 314 7e-86 3MDV-A nrPDB 311 5e-85 5E58-A nrPDB 310 1e-84 3IBD-A nrPDB 300 9e-82 5VEU-A nrPDB 285 3e-77 3DL9-A nrPDB 272 2e-73 6HQW-A nrPDB 272 3e-73 6DA2-A nrPDB 270 1e-72 6C94-A nrPDB 268 4e-72 6B82-A nrPDB 256 2e-68 4WMZ-A nrPDB 247 1e-65 5JLC-A nrPDB 245 5e-65 4R1Z-A nrPDB 241 5e-64 4R20-A nrPDB 241 6e-64 5UYS-A nrPDB 237 9e-63 6DWN-A nrPDB 236 1e-62 2HI4-A nrPDB 236 2e-62 3TBG-A nrPDB 233 2e-61 5VBU-A nrPDB 226 2e-59 3QZ1-A nrPDB 220 1e-57 5YLW-A nrPDB 219 2e-57 2VE3-A nrPDB 218 6e-57 3RWL-A nrPDB 216 2e-56 6IQ5-A nrPDB 212 3e-55 6HQG-A nrPDB 210 1e-54 6AYB-A nrPDB 209 2e-54 5FSA-A nrPDB 206 1e-53 1UED-A nrPDB 205 3e-53 3JUS-A nrPDB 204 1e-52 5H1Z-A nrPDB 203 1e-52 4KPA-A nrPDB 201 8e-52 5OFQ-A nrPDB 200 2e-51 3EJB-B nrPDB 200 2e-51 3EL3-A nrPDB 198 3e-51 3S79-A nrPDB 194 7e-50 5VWS-A nrPDB 191 6e-49 5FYF-A nrPDB 191 7e-49 4RM4-A nrPDB 189 2e-48 3L4D-A nrPDB 189 3e-48 2WX2-A nrPDB 188 4e-48 6CR2-A nrPDB 187 8e-48 5L94-A nrPDB 184 5e-47 2W0A-A nrPDB 184 8e-47 6HQD-A nrPDB 183 1e-46 2XKR-A nrPDB 181 7e-46 4TRI-A nrPDB 181 8e-46 5LIV-A nrPDB 179 2e-45 6F88-A nrPDB 179 3e-45 2WIO-A nrPDB 178 4e-45 2X2N-A nrPDB 177 1e-44 1CPT-A nrPDB 177 1e-44 2ZBZ-A nrPDB 176 1e-44 6GMF-A nrPDB 174 5e-44 6B11-A nrPDB 174 6e-44 5LIE-A nrPDB 173 1e-43 5XW2-A nrPDB 173 2e-43 6CVC-A nrPDB 173 2e-43 3R9C-A nrPDB 172 2e-43 5FOI-A nrPDB 172 3e-43 3MGX-A nrPDB 171 6e-43 2VZM-A nrPDB 171 7e-43 4UBS-A nrPDB 170 1e-42 3A50-A nrPDB 169 2e-42 4YZR-A nrPDB 169 3e-42 4PWV-A nrPDB 169 4e-42 5XJN-A nrPDB 168 4e-42 5GWE-A nrPDB 168 6e-42 2Y5N-A nrPDB 167 1e-41 6GK6-A nrPDB 166 1e-41 3TYW-A nrPDB 166 2e-41 4OQR-A nrPDB 164 1e-40 6G5O-A nrPDB 163 2e-40 4WPZ-A nrPDB 162 3e-40 2Z36-A nrPDB 162 3e-40 3ABB-A nrPDB 161 6e-40 3TKT-A nrPDB 161 6e-40 2RFC-A nrPDB 159 3e-39 3ABA-A nrPDB 158 4e-39 5IT1-A nrPDB 158 4e-39 3NC3-A nrPDB 155 3e-38 2FR7-A nrPDB 154 8e-38 4MM0-A nrPDB 153 2e-37 5HDI-A nrPDB 151 8e-37 3A1L-A nrPDB 151 8e-37 6F0B-A nrPDB 150 1e-36 1UE8-A nrPDB 150 1e-36 5YSW-A nrPDB 150 1e-36 6GII-A nrPDB 149 2e-36 5HIW-A nrPDB 148 4e-36 5DE9-A nrPDB 148 5e-36 3SN5-A nrPDB 147 1e-35 6G71-A nrPDB 141 8e-34 3OFT-A nrPDB 136 2e-32 5D3U-A nrPDB 127 1e-29 1WIY-A nrPDB 126 3e-29 6FYJ-A nrPDB 122 4e-28 5YHJ-A nrPDB 121 6e-28 5M0P-A nrPDB 114 6e-26 2IAG-A nrPDB 111 5e-25 2ZQJ-A nrPDB 104 8e-23 Sequences not found previously or not previously below threshold: 2WM5-A nrPDB 178 4e-45 5DQN-A nrPDB 172 2e-43 4GGV-A nrPDB 170 1e-42 4OQS-A nrPDB 167 1e-41 5CJE-A nrPDB 166 2e-41 3WVS-A nrPDB 164 8e-41 4Z5P-A nrPDB 163 1e-40 5Y1I-A nrPDB 163 2e-40 5Z9I-A nrPDB 163 2e-40 4YT3-A nrPDB 162 3e-40 5EX6-C nrPDB 162 3e-40 5XNT-A nrPDB 159 3e-39 6FSH-A nrPDB 156 2e-38 1Z8P-A nrPDB 156 2e-38 4TX3-A nrPDB 155 3e-38 1LG9-A nrPDB 155 5e-38 1EHE-A nrPDB 153 2e-37 3P3Z-A nrPDB 151 8e-37 5NWS-A nrPDB 151 8e-37 3IVY-A nrPDB 149 2e-36 1F4U-A nrPDB 149 3e-36 1ODO-A nrPDB 147 1e-35 4Z5Q-A nrPDB 146 2e-35 4JBT-A nrPDB 146 2e-35 4XE3-A nrPDB 146 3e-35 4DO1-A nrPDB 144 6e-35 6M7L-A nrPDB 142 3e-34 6A7I-A nrPDB 141 5e-34 6DCD-A nrPDB 140 1e-33 6A7J-A nrPDB 139 2e-33 2UUQ-A nrPDB 139 3e-33 2X9P-A nrPDB 134 7e-32 6BLD-A nrPDB 134 9e-32 5L1U-A nrPDB 133 1e-31 1Q5D-A nrPDB 133 2e-31 1GWI-A nrPDB 129 2e-30 2WIY-A nrPDB 128 6e-30 2NZA-A nrPDB 125 4e-29 3BUJ-A nrPDB 125 5e-29 3OO3-A nrPDB 124 1e-28 2IJ7-A nrPDB 123 2e-28 3WEC-A nrPDB 122 3e-28 4FB2-A nrPDB 119 4e-27 5HH3-A nrPDB 117 1e-26 5EX8-A nrPDB 107 8e-24 5OMS-A nrPDB 106 2e-23 3NV6-A nrPDB 106 3e-23 5KYO-A nrPDB 104 8e-23 2QBO-A nrPDB 103 2e-22 2RCM-A nrPDB 102 3e-22 3AWQ-A nrPDB 98 8e-21 4C9K-A nrPDB 98 1e-20 3B98-A nrPDB 89 3e-18 3DBM-A nrPDB 85 7e-17 2YJN-B nrPDB 68 9e-12 6F73-A nrPDB 35 0.073 4YXC-B nrPDB 33 0.24 3GFZ-A nrPDB 33 0.26 2XTZ-A nrPDB 32 0.82 1R6B-X nrPDB 31 0.93 4YXB-D nrPDB 31 1.6 4N4R-A nrPDB 29 4.4 2C4R-L nrPDB 29 6.4 >4ZGX-A nrPDB Length = 489 Score = 616 bits (1587), Expect = e-176, Method: Composition-based stats. Identities = 477/480 (99%), Positives = 479/480 (99%) Query: 24 LGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL 83 + T+AARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL Sbjct: 1 MATKAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL 60 Query: 84 GGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 143 GGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR Sbjct: 61 GGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 120 Query: 144 LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203 LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA Sbjct: 121 LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 180 Query: 204 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCI 263 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCI Sbjct: 181 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCI 240 Query: 264 FQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPL 323 FQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPL Sbjct: 241 FQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPL 300 Query: 324 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE Sbjct: 301 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 360 Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF Sbjct: 361 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 420 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 503 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN Sbjct: 421 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 480 >6M7X-A nrPDB Length = 484 Score = 565 bits (1457), Expect = e-161, Method: Composition-based stats. Identities = 442/480 (92%), Positives = 454/480 (94%) Query: 24 LGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL 83 + + + PRTVLPFEAMP+ PGNRWLRLLQIWREQGYE LHLE+HQTFQELGPIFRY+L Sbjct: 1 MAKKTSSVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 60 Query: 84 GGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 143 GG MVCVMLPEDVEKLQQVDSLHP RM LEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR Sbjct: 61 GGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 120 Query: 144 LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203 LNP+VLSP AVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA Sbjct: 121 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 180 Query: 204 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCI 263 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRW SPKVWKEHFEAWDCI Sbjct: 181 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCI 240 Query: 264 FQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPL 323 FQYGDNCIQKIYQELAF+RPQ YT IVAELLL AELS +AIKANSMELTAGSVDTT FPL Sbjct: 241 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL 300 Query: 324 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 LMTLFELARNP+VQQ LRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE Sbjct: 301 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 360 Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 RV SSDLVLQNYHIPAGTLV+VFLYSLGRN ALFPRPERYNPQRWLDIRGSGRNF+HVPF Sbjct: 361 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 420 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 503 GFGMRQCLGRRLAEAEMLLLLHHVLKH VETLTQEDIKMVYSFILRP PLLTFRAIN Sbjct: 421 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 480 >3N9Z-A nrPDB Length = 487 Score = 500 bits (1287), Expect = e-142, Method: Composition-based stats. Identities = 187/478 (39%), Positives = 274/478 (57%), Gaps = 5/478 (1%) Query: 28 AARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPR 87 + R+PR PF +P N WL L WRE G +HL Q FQ+ GPI+R LG Sbjct: 1 STRSPR---PFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVE 57 Query: 88 MVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPD 147 V V+ PEDV L + + +P R ++ PWVAY Q+ GV L W+ +R+ LN + Sbjct: 58 SVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQE 117 Query: 148 VLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 V++P+A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ +FGE Sbjct: 118 VMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGE 177 Query: 208 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYG 267 R G++ + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF Sbjct: 178 RQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKA 237 Query: 268 DNCIQKIYQELAFNRPQHYT--GIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLM 325 D Q Y EL H+ GI+ LL +++S E IKAN E+ AG VDTT+ L Sbjct: 238 DIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQW 297 Query: 326 TLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERV 385 L+E+ARN VQ +LR E LAA +PLL+A++KETLRL+P+ + L+R Sbjct: 298 HLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRY 357 Query: 386 VSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGF 445 + +DLVL++Y IPA TLVQV +Y+LGR F PE ++P RWL + F ++ FG+ Sbjct: 358 LVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGW 417 Query: 446 GMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 503 G+RQCLGRR+AE EM + L ++L++F VE D+ ++ IL P TF N Sbjct: 418 GVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFN 475 >3MZS-A nrPDB Length = 486 Score = 496 bits (1277), Expect = e-141, Method: Composition-based stats. Identities = 177/477 (37%), Positives = 282/477 (59%), Gaps = 4/477 (0%) Query: 28 AARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPR 87 + + PR P+ +P N WL L WRE+G + +H + FQ+ GPI+R LG Sbjct: 3 STKTPR---PYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLE 59 Query: 88 MVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPD 147 V ++ PEDV L + + +P R + PW+AY ++ GV W+ +R+ LN + Sbjct: 60 SVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTE 119 Query: 148 VLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 V++P+A++ F+P+++ V++DF L K++ Q G D++ +FH+ E+ +FGE Sbjct: 120 VMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGE 179 Query: 208 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYG 267 RLG++ + + + F+ A+ MF ++V L+ +P L R K W++H AWD IF Sbjct: 180 RLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKA 239 Query: 268 DNCIQKIYQELAFNRP-QHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMT 326 + + YQ+L ++Y GI+ LL ++ LE +KAN E+ AG V+TT+ L Sbjct: 240 EKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWH 299 Query: 327 LFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVV 386 L+E+AR+ +VQ++LR+E L A K +PLL+A++KETLRL+P+ + L+R Sbjct: 300 LYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYP 359 Query: 387 SSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFG 446 SDLVLQ+Y IPA TLVQV +Y++GR+ A F P++++P RWL +F ++ FG+G Sbjct: 360 ESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWG 419 Query: 447 MRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 503 +RQC+GRR+AE EM L L H+L++F VE D+ +++ IL P L FR N Sbjct: 420 VRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFN 476 >3K9V-A nrPDB Length = 482 Score = 411 bits (1057), Expect = e-115, Method: Composition-based stats. Identities = 135/459 (29%), Positives = 225/459 (49%), Gaps = 8/459 (1%) Query: 45 PGNRWL--RLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQ 102 P N L LL+I+ + G + H + + ++ G IFR LG V + P +E L + Sbjct: 29 PTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYR 88 Query: 103 VDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVD 162 +S HP R+ ++PW AYR HR G+ +L G EW+ R ++ P + + ++ Sbjct: 89 TESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKIN 148 Query: 163 AVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLN 222 V DF + + + L + RG + D+ + ++ E+ L L+ +R GL+ +L Sbjct: 149 EVLADFLERMDE--LCDERGRIP-DLYSELNKWSFESICLVLYEKRFGLLQKETEEEALT 205 Query: 223 FLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNR 282 F+ A++ M + ++M P L + ++ KVW+ H AWD IF+ CI Q Sbjct: 206 FITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRY---S 262 Query: 283 PQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQ 342 Q + ++ + LS + + A EL +V+TTA L+ L+ L+RNP Q+ L Q Sbjct: 263 QQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQ 322 Query: 343 ESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTL 402 E + + +P L+A LKE++RL P F R + VL Y +P GT+ Sbjct: 323 EVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTV 382 Query: 403 VQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLL 462 + + LG + F ++ P+RWL F H+PFG G R C+GRRLAE ++ L Sbjct: 383 LTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHL 442 Query: 463 LLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRA 501 L +++ + + E ++M++ IL P + FR Sbjct: 443 ALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP 481 >2PG7-A nrPDB Length = 476 Score = 344 bits (882), Expect = 5e-95, Method: Composition-based stats. Identities = 94/452 (20%), Positives = 178/452 (39%), Gaps = 24/452 (5%) Query: 44 HPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQV 103 PG L + + + E ++ + + + GP+F +LG PR V V+ D + V Sbjct: 12 PPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLG-PRRVVVLCGHDAVREALV 70 Query: 104 DSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRF-NRLRLNPDVLSPKAVQRFLPMVD 162 D E +G+ GV NG + R + + + Sbjct: 71 DQAEEFSGRGEQATFDWVFKGY--GVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQ 128 Query: 163 AVARDFSQALKKKVLQNARGSLTLDVQPSIF--HYTIEASNLALFGERLGLVGHSPSSAS 220 A AL RG+ ++ P+ F + +FG+R S Sbjct: 129 EEAGFLIDAL--------RGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLL 180 Query: 221 LNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF 280 L + ST QL M S+ + + P ++ F+ + + ++ + L Sbjct: 181 RMMLGIFQFTSTSTGQLYEMFSSVMKHL-PGPQQQAFQLLQGLEDFIAKKVEHNQRTLDP 239 Query: 281 NRPQHYTGIVAELLLK------AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNP 334 N P+ + + + E L+ + +++L G +T + L L ++P Sbjct: 240 NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHP 299 Query: 335 DVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF-LERVVSSDLVLQ 393 +V+ + +E + + ++P + A + E R V L R V D + Sbjct: 300 EVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFR 359 Query: 394 NYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLG 452 ++ +P GT V L S+ R+ + F P+ +NPQ +L+ +G ++ VPF G R C G Sbjct: 360 DFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFG 419 Query: 453 RRLAEAEMLLLLHHVLKHFLVE-TLTQEDIKM 483 LA E+ L V+++F ++ + + +DI + Sbjct: 420 EGLARMELFLFFTTVMQNFRLKSSQSPKDIDV 451 >3E6I-A nrPDB Length = 476 Score = 334 bits (857), Expect = 5e-92, Method: Composition-based stats. Identities = 104/475 (21%), Positives = 181/475 (38%), Gaps = 38/475 (8%) Query: 44 HPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDV-EKLQQ 102 PG L ++ + +++ + Q GP+F +G RMV + + V E L Sbjct: 12 PPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 71 Query: 103 VDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWR-FNRLRLNPDVLSPKAVQRFLPMV 161 R L + A+R G+ NGP W+ R L Q + Sbjct: 72 YKDEFSGRGDLPAFHAHRDR-----GIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRI 126 Query: 162 DAVARDFSQALKKKVLQNARGSLTLDVQPS------IFHYTIEASN------LALFGERL 209 A +AL+K Q + + P +F + ++ + LF E Sbjct: 127 QREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENF 186 Query: 210 GLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDN 269 L+ NF L + S +++ + ++S +V KEH ++ D N Sbjct: 187 HLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERV-KEHHQSLD------PN 239 Query: 270 CIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFE 329 C + + L + + +++ I +L +TT+ L L Sbjct: 240 CPRDLTDCLLVEMEKEKHS------AERLYTMDGITVTVADLFFAGTETTSTTLRYGLLI 293 Query: 330 LARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF-LERVVSS 388 L + P++++ L +E K E+P + A + E R + L + Sbjct: 294 LMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATR 353 Query: 389 DLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGR-NFHHVPFGFGM 447 D + + Y IP GT+V L S+ + FP PE++ P+ +L+ G + + + PF G Sbjct: 354 DTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGK 413 Query: 448 RQCLGRRLAEAEMLLLLHHVLKHFLVETL-TQEDIKMVY---SFILRPGTSPLLT 498 R C G LA E+ LLL +L+HF ++ L +DI + F P L Sbjct: 414 RVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCV 468 >5W0C-A nrPDB Length = 477 Score = 329 bits (843), Expect = 2e-90, Method: Composition-based stats. Identities = 99/457 (21%), Positives = 180/457 (39%), Gaps = 45/457 (9%) Query: 44 HPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDV-EKLQQ 102 PG L ++ + G + + + + GP+F G +V + E V E L Sbjct: 13 PPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 72 Query: 103 VDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWR-FNRLRLNPDVLSPKAVQRFLPMV 161 + R I +A R +RG G+ NG +W+ R L + V Sbjct: 73 LGEEFSGRGIFP--LAERANRGF--GIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRV 128 Query: 162 DAVARDFSQALKKKVLQNARGSLTLDVQPS------IFHYTIEASN------LALFGERL 209 AR + L+K + L P IFH + + + E + Sbjct: 129 QEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENI 188 Query: 210 GLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDN 269 ++ NF ++ + +L+ + +I KV KEH E+ D Sbjct: 189 KILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKV-KEHQESMD-------- 239 Query: 270 CIQKIYQELAFNRPQHYTGIVAELLLK------AELSLEAIKANSMELTAGSVDTTAFPL 323 N PQ + + K +E ++E+++ +++L +TT+ L Sbjct: 240 ----------MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTL 289 Query: 324 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL-FL 382 L L ++P+V +++E + + +P A + E R + L Sbjct: 290 RYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSL 349 Query: 383 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS-GRNFHHV 441 V+ D+ +NY IP GT + + L S+ + FP PE ++P +LD G+ ++ + + Sbjct: 350 PHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFM 409 Query: 442 PFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQ 478 PF G R C+G LA E+ L L +L++F +++L Sbjct: 410 PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD 446 >4GQS-A nrPDB Length = 477 Score = 323 bits (828), Expect = 9e-89, Method: Composition-based stats. Identities = 90/462 (19%), Positives = 174/462 (37%), Gaps = 23/462 (4%) Query: 44 HPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQV 103 PG L ++ + + + + + GP+F G RMV + E V K + Sbjct: 13 PPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYE-VVKEALI 71 Query: 104 DSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWR-FNRLRLNPDVLSPKAVQRFLPMVD 162 D +A R +RG G+ NG W+ R L + V Sbjct: 72 DLGEEFSGRGHFPLAERANRGF--GIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQ 129 Query: 163 AVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLN 222 AR + L+K + L P +F +R + Sbjct: 130 EEARCLVEELRKTKASPCDPTFILGCAPC------NVICSIIFQKRFDYKDQQFLNLMEK 183 Query: 223 FLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNR 282 + ++ +Q+ ++ + P + + + +++ + + N Sbjct: 184 LNENIRIVSTPWIQICNNFPTIIDYF-PGTHNKLLKNLAFMESDILEKVKEHQESMDINN 242 Query: 283 PQHYTGIVAELLLK------AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDV 336 P+ + + K +E ++E + + +L +TT+ L L L ++P+V Sbjct: 243 PRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEV 302 Query: 337 QQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL-FLERVVSSDLVLQNY 395 +++E + +P A + E R + L V+ D+ +NY Sbjct: 303 TAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNY 362 Query: 396 HIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLGRR 454 IP GT + L S+ + FP PE ++P+ +LD G+ ++ + +PF G R C+G Sbjct: 363 LIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEG 422 Query: 455 LAEAEMLLLLHHVLKHFLVETL-TQEDIK---MVYSFILRPG 492 LA E+ L L +L++F +++L +D+ +V F P Sbjct: 423 LARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPP 464 >1N6B-A nrPDB Length = 473 Score = 323 bits (827), Expect = 1e-88, Method: Composition-based stats. Identities = 89/465 (19%), Positives = 175/465 (37%), Gaps = 22/465 (4%) Query: 44 HPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDV-EKLQQ 102 PG ++ + + + + + + GP+F LG V + E V E L Sbjct: 12 PPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEAVKEALVD 71 Query: 103 VDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRF-NRLRLNPDVLSPKAVQRFLPMV 161 + R + + G+ N W+ R L + + Sbjct: 72 LGEEFAGRGSVPIL----EKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGKRSIEDRI 127 Query: 162 DAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASL 221 AR + L+K + L P +F R Sbjct: 128 QEEARCLVEELRKTNASPCDPTFILGCAPC------NVICSVIFHNRFDYKDEEFLKLME 181 Query: 222 NFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFN 281 + +E++ +Q+ +L + P + K + D I + +++ + L N Sbjct: 182 SLHENVELLGTPWLQVYNNFPALLDYF-PGIHKTLLKNADYIKNFIMEKVKEHQKLLDVN 240 Query: 282 RPQHYTGIVAELLLKA---ELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQ 338 P+ + + + E +LE++ +L +TT+ L +L L ++P+V Sbjct: 241 NPRDFIDCFLIKMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVAA 300 Query: 339 ILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF-LERVVSSDLVLQNYHI 397 +++E + + +P A + E R + L V+ D+ +NY I Sbjct: 301 RVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRNYFI 360 Query: 398 PAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLGRRLA 456 P GT + L S+ + FP P+ ++P +LD G+ ++ + +PF G R C+G LA Sbjct: 361 PKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGEGLA 420 Query: 457 EAEMLLLLHHVLKHFLVETLT-QEDIK---MVYSFILRPGTSPLL 497 E+ L L +L++F +++L +D+ +V F+ P + L Sbjct: 421 RMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLC 465 >4H1N-A nrPDB Length = 479 Score = 317 bits (812), Expect = 6e-87, Method: Composition-based stats. Identities = 94/467 (20%), Positives = 163/467 (34%), Gaps = 20/467 (4%) Query: 44 HPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQV 103 PG L +L + + L + ++ G +F LG R V V+ D + V Sbjct: 12 PPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGS-RPVVVLCGTDAIREALV 70 Query: 104 DSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWR-FNRLRLNPDVLSPKAVQRFLPMVD 162 D + V +G+ GV NG WR R L + + Sbjct: 71 DQAEAFSGRGKIAVVDPIFQGY--GVIFANGERWRALRRFSLATMRDFGMGKRSVEERIQ 128 Query: 163 AVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLN 222 AR + L+K LD T +FG+R Sbjct: 129 EEARCLVEELRK------SKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLLDL 182 Query: 223 FLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNR 282 F + ++ + Q+ + ++ P ++ + I + ++K L + Sbjct: 183 FFQSFSLISSFSSQVFELFSGFLKYF-PGTHRQIYRNLQEINTFIGQSVEKHRATLDPSN 241 Query: 283 PQHYTGIVAELLLK------AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDV 336 P+ + + + K +E + + + L A +TT+ L + + P V Sbjct: 242 PRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPHV 301 Query: 337 QQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF-LERVVSSDLVLQNY 395 + +++E S ++P A + E RL + F + V+ D + Y Sbjct: 302 TERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGY 361 Query: 396 HIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLGRR 454 IP T V L S + F P +NP +LD G+ RN +PF G R CLG Sbjct: 362 VIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGEG 421 Query: 455 LAEAEMLLLLHHVLKHFLV-ETLTQEDIKMVYSFILRPGTSPLLTFR 500 +A E+ L +L++F + + EDI + P R Sbjct: 422 IARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIR 468 >5E0E-A nrPDB Length = 463 Score = 314 bits (805), Expect = 4e-86, Method: Composition-based stats. Identities = 79/428 (18%), Positives = 154/428 (35%), Gaps = 20/428 (4%) Query: 66 LEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGH 125 + ++ G +F +LG PR V ++ + + VD V RG+ Sbjct: 25 NSFRRIREKYGDVFTVHLG-PRPVVMLYGTEAIREALVDQAEAFSGRGTIAVVEPIFRGY 83 Query: 126 KCGVFLLNGPEWR-FNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSL 184 GV NG W+ R L + + AR + +K + Sbjct: 84 --GVVFANGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQGAPLDPTF 141 Query: 185 TLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSL 244 T +FGER H F + ++ + Q+ + Sbjct: 142 LFQC------ITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFSGF 195 Query: 245 SRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLK------AE 298 ++ P ++ I Y ++K L + P+ + + K E Sbjct: 196 LKYF-PGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHTE 254 Query: 299 LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKA 358 + + + + L +T++ L + + P V + +++E S + Sbjct: 255 FDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLED 314 Query: 359 TTELPLLRAALKETLRLYP-VGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALF 417 T++P A + E R + + + V+ D + + Y +P T V L S + F Sbjct: 315 RTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYF 374 Query: 418 PRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLV-ET 475 +P+ +NP +LD G+ ++ +PF G R CLG +A E+ L +L++F + Sbjct: 375 EQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLSSP 434 Query: 476 LTQEDIKM 483 + +DI + Sbjct: 435 VAPKDIDL 442 >2NNH-A nrPDB Length = 476 Score = 314 bits (803), Expect = 7e-86, Method: Composition-based stats. Identities = 80/444 (18%), Positives = 157/444 (35%), Gaps = 19/444 (4%) Query: 44 HPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQV 103 PG L ++ + + + + GP+F G + V + K + Sbjct: 12 PPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFG-MNPIVVFHGYEAVKEALI 70 Query: 104 DSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWR-FNRLRLNPDVLSPKAVQRFLPMVD 162 D+ ++ R +G G+ NG W+ R L + V Sbjct: 71 DNGEEFSGRGNSPISQRITKG--LGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQ 128 Query: 163 AVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLN 222 A + L+K + L P +F +R + + Sbjct: 129 EEAHCLVEELRKTKASPCDPTFILGCAPC------NVICSVVFQKRFDYKDQNFLTLMKR 182 Query: 223 FLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNR 282 F ++ +Q+ L P + + Y +++ L N Sbjct: 183 FNENFRILNSPWIQVCNNFPLLIDCF-PGTHNKVLKNVALTRSYIREKVKEHQASLDVNN 241 Query: 283 PQHYTGIVAELLL------KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDV 336 P+ + + K+E ++E + +L +TT+ L L L ++P+V Sbjct: 242 PRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEV 301 Query: 337 QQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL-FLERVVSSDLVLQNY 395 +++E + + +P A + E R + + V++D +NY Sbjct: 302 TAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNY 361 Query: 396 HIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLGRR 454 IP GT + L S+ + FP P ++P +LD G+ ++ + +PF G R C G Sbjct: 362 LIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEG 421 Query: 455 LAEAEMLLLLHHVLKHFLVETLTQ 478 LA E+ L L +L++F ++++ Sbjct: 422 LARMELFLFLTTILQNFNLKSVDD 445 >3MDV-A nrPDB Length = 456 Score = 311 bits (796), Expect = 5e-85, Method: Composition-based stats. Identities = 96/448 (21%), Positives = 168/448 (37%), Gaps = 17/448 (3%) Query: 58 EQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEK-LQQVDSLHPCRMILEPW 116 E G L ++ GP+ R N+ V V PE V+K L +M Sbjct: 6 EVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQ 65 Query: 117 VAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKV 176 + + + V N W R R+ S ++ + + A + L+ K Sbjct: 66 TVFGERLFGQGLVSECNYERWHKQR-RVIDLAFSRSSLVSLMETFNEKAEQLVEILEAK- 123 Query: 177 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 236 A G + +Q + + ++ A FG ++ + S LE + S Sbjct: 124 ---ADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNT 180 Query: 237 LMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLK 296 L K +E E+ + Q G + +Q+ + L R + + +LK Sbjct: 181 LAKFLPG-----KRKQLREVRESIRFLRQVGRDWVQRRREAL--KRGEEVPADILTQILK 233 Query: 297 AEL---SLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISE 353 AE E + N + +T+A L T+ EL+R P++ L+ E S Sbjct: 234 AEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY 293 Query: 354 HPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRN 413 + L L LKE+LRLYP R++ + ++ +P T + Y +GR Sbjct: 294 LDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRM 353 Query: 414 AALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLV 473 F P +NP R+ F + PF G R C+G++ A+ E+ +++ +L+ Sbjct: 354 DTYFEDPLTFNPDRF-GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 412 Query: 474 ETLTQEDIKMVYSFILRPGTSPLLTFRA 501 + + + L+P L T R Sbjct: 413 RLVPGQRFGLQEQATLKPLDPVLCTLRP 440 >5E58-A nrPDB Length = 493 Score = 310 bits (793), Expect = 1e-84, Method: Composition-based stats. Identities = 78/428 (18%), Positives = 150/428 (35%), Gaps = 20/428 (4%) Query: 66 LEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGH 125 + ++ G +F +LG PR V ++ + + VD +A + Sbjct: 53 NSFMRIREKYGDVFTVHLG-PRPVVMLYGTEAIREALVDQAEAFSGRGT--IAVIKPVIG 109 Query: 126 KCGVFLLNGPEWR-FNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSL 184 G+ NG W+ R L + + A+ + L+K + Sbjct: 110 DYGMIFSNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQGAPLDPTF 169 Query: 185 TLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSL 244 T +FGER F +M + Q+ + Sbjct: 170 LFQC------ITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFSGF 223 Query: 245 SRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLK------AE 298 ++ P ++ I Y ++K L + P+ + + K E Sbjct: 224 MKYF-PGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHTE 282 Query: 299 LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKA 358 + + + + L +TT+ L + + P V + +++E S + Sbjct: 283 FHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLED 342 Query: 359 TTELPLLRAALKETLRLYPVGL-FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALF 417 T++P A + E R + V+ D + + Y +P T V L S + F Sbjct: 343 RTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYF 402 Query: 418 PRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLV-ET 475 +P +NP +LD G+ ++ +PF G R CLG +A E+ L +L++F V + Sbjct: 403 EQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSSS 462 Query: 476 LTQEDIKM 483 + +DI + Sbjct: 463 VAPKDIDL 470 >3IBD-A nrPDB Length = 476 Score = 300 bits (768), Expect = 9e-82, Method: Composition-based stats. Identities = 84/460 (18%), Positives = 161/460 (35%), Gaps = 24/460 (5%) Query: 51 RLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCR 110 LLQ+ R + + ++ G +F +LG PR V ++ + + VD Sbjct: 23 NLLQMDRRGLLK----SFLRFREKYGDVFTVHLG-PRPVVMLCGVEAIREALVDKAEAFS 77 Query: 111 MILEPWVAYRQHRGHKCGVFLLNGPEWR-FNRLRLNPDVLSPKAVQRFLPMVDAVARDFS 169 + + RG+ GV NG W+ R + + + A+ Sbjct: 78 GRGKIAMVDPFFRGY--GVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLI 135 Query: 170 QALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEV 229 + L+K + T +FG+R F + Sbjct: 136 EELRKSKGALMDPTFLFQ------SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSL 189 Query: 230 MFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGI 289 + QL + + P ++ ++ I Y + ++K + L + P+ Sbjct: 190 ISSVFGQLFELFSGFLKHF-PGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDT 248 Query: 290 VAELLLK------AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE 343 + K +E S + + N++ L +TT+ L + + P V + + +E Sbjct: 249 YLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYRE 308 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF-LERVVSSDLVLQNYHIPAGTL 402 ++P A + E R + + +V+ + Y IP T Sbjct: 309 IEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTE 368 Query: 403 VQVFLYSLGRNAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLGRRLAEAEML 461 V + L + + F +P+ +NP +LD G+ + +PF G R CLG +A AE+ Sbjct: 369 VFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELF 428 Query: 462 LLLHHVLKHFLV-ETLTQEDIKMVYSFILRPGTSPLLTFR 500 L +L++F + + EDI + P R Sbjct: 429 LFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIR 468 >5VEU-A nrPDB Length = 480 Score = 285 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 112/477 (23%), Positives = 200/477 (41%), Gaps = 49/477 (10%) Query: 45 PGNRWLRLLQI---WREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQ 101 PG L LL +R+ L + +++ G ++ G ++ + P DV + Sbjct: 18 PGPTPLPLLGNVLSYRQG----LWKFDTECYKKYGKMWGTYEGQLPVLAITDP-DVIRTV 72 Query: 102 QVD---SLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFL 158 V S+ R L P K + L EW+ R L+P S K + F Sbjct: 73 LVKECYSVFTNRRSLGPVG------FMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMF- 125 Query: 159 PMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSS 218 + + L + + + A + ++ Y+++ G G+ S ++ Sbjct: 126 ----PIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVIT----GTSFGVNIDSLNN 177 Query: 219 ASLNFLHALEVMFK-STVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGD--NCIQKIY 275 F+ + + K + +F+ L +++P FEA + D N + K Sbjct: 178 PQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPV-----FEALNVSLFPKDTINFLSKSV 232 Query: 276 QELAFNR---PQHYTGIVAELLLKAELSLE----------AIKANSMELTAGSVDTTAFP 322 + +R Q + +L++ ++ S E + A S+ +TT+ Sbjct: 233 NRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSV 292 Query: 323 LLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382 L TL+ELA +PDVQQ L++E A + + A ++ L + ETLRL+PV + L Sbjct: 293 LSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRL 352 Query: 383 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVP 442 ER D+ + IP G++V + Y+L + + PE + P+R+ + S + + P Sbjct: 353 ERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTP 412 Query: 443 FGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL--TQEDIKMVYSFILRPGTSPLL 497 FG G R C+G R A M L L VL++F + TQ +K+ +L+P +L Sbjct: 413 FGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVL 469 >3DL9-A nrPDB Length = 479 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 100/451 (22%), Positives = 164/451 (36%), Gaps = 28/451 (6%) Query: 65 HLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRG 124 H+ M + Q G IF +LGG V + DV K V P + Sbjct: 37 HVYMRKQSQVYGEIFSLDLGGISTVVLNGY-DVVKECLVHQS--EIFADRPCLPLFMKMT 93 Query: 125 HKCGVFLLNGPE-W-RFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARG 182 G+ W RL +N + F + + F+ A++ Sbjct: 94 KMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIE------TYK 147 Query: 183 SLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPR 242 D + I + +NL +FGER F +E+ ++V L Sbjct: 148 GRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP 207 Query: 243 SLSRWISPKVWKEH---FEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE- 298 WI + +H F ++ + I+K PQH+ + + + + Sbjct: 208 ----WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKN 263 Query: 299 -----LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISE 353 S E + + EL +TT L + +A P++Q +++E + Sbjct: 264 DPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGK 323 Query: 354 HPQKATTELPLLRAALKETLRLYPVGL-FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGR 412 ++P A L E LR + + S D V++ Y IP GT V LYS+ Sbjct: 324 PSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHF 383 Query: 413 NAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 + + PE ++P+R+LD G + VPF G R CLG LA EM L +L+ F Sbjct: 384 DEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 443 Query: 472 LVETLTQ--EDIKMVYSFILRPGTSPLLTFR 500 + + D+K L+P + R Sbjct: 444 HLHFPHELVPDLKPRLGMTLQPQPYLICAER 474 >6HQW-A nrPDB Length = 445 Score = 272 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 80/392 (20%), Positives = 153/392 (39%), Gaps = 42/392 (10%) Query: 110 RMILEPWVAYRQHRGHKCGVFLLNGPE-----WRFNRLRLNP---DVLSPKAVQRFLPMV 161 R+ P+ AY HK + + + PE W++ + + DV K +R LPM Sbjct: 70 RVPDSPYGAYWNVASHKAIMHVESLPELFSSSWQYGGITIGDPPEDVDPQKLAERQLPMF 129 Query: 162 DAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASL 221 A+ R ++ V + ++++ I T + +GER V + Sbjct: 130 IAMDRPDHTGQRRTVAPAFTPAKMVEMEAEIRRRTASVLDSLPWGERFDWVDKVSIELTT 189 Query: 222 NFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFN 281 L L + +L+ S W E D F + + +Q L Sbjct: 190 GMLAILFGFPWADRRLLTF---WSDWAGDVELTLARELADTRFGFLGE-MAHYFQRLWGA 245 Query: 282 RPQ-HYTGIVAELLLKAE----LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDV 336 R Q +G + +++ +E +S + N + L G DTT + + L + PD Sbjct: 246 RMQAPPSGDLISMMIHSEAMNHMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPDQ 305 Query: 337 QQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYH 396 +++L +++ L+ A++E +R + R ++D L Sbjct: 306 RELLERDA------------------SLIPNAVQECIRYVTPLAHMRRTATADTELFGNQ 347 Query: 397 IPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLA 456 I AG V ++ S R+ +F P++ R H+ FG G+ +C+G RLA Sbjct: 348 IKAGEKVILWYISANRDETVFENPDKLMVDR-------PNARRHLSFGHGIHRCVGARLA 400 Query: 457 EAEMLLLLHHVLKHFLVETLTQEDIKMVYSFI 488 E ++ +LL + + + + E ++ +F+ Sbjct: 401 ELQLRILLEEMHERRMRVRVAGEVERVRANFV 432 >6DA2-A nrPDB Length = 487 Score = 270 bits (690), Expect = 1e-72, Method: Composition-based stats. Identities = 95/471 (20%), Positives = 189/471 (40%), Gaps = 36/471 (7%) Query: 45 PGNRWLRLLQIWREQGYEHLHLEM-HQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQV 103 PG L L Y + ++ G ++ + G ++ + P D+ K V Sbjct: 19 PGPTPLPFLGNIL--SYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDP-DMIKTVLV 75 Query: 104 DSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDA 163 + P+ K + + EW+ R L+P S K + Sbjct: 76 KECYSVFTNRRPFGPVG---FMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEM-----VP 127 Query: 164 VARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNF 223 + + L + + + A + ++ Y+++ FG + + ++ F Sbjct: 128 IIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSL----NNPQDPF 183 Query: 224 LHALEVMFKST-VQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNR 282 + + + + + F+ ++ ++ P + + N ++K + + +R Sbjct: 184 VENTKKLLRFDFLDPFFLSITVFPFLIPIL---EVLNICVFPREVTNFLRKSVKRMKESR 240 Query: 283 ---PQHYTGIVAELLLKAELSLE----------AIKANSMELTAGSVDTTAFPLLMTLFE 329 Q + +L++ ++ S E + A S+ +TT+ L ++E Sbjct: 241 LEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYE 300 Query: 330 LARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSD 389 LA +PDVQQ L++E A + + ++ L + ETLRL+P+ + LERV D Sbjct: 301 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKD 360 Query: 390 LVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG-RNFHHVPFGFGMR 448 + + IP G +V + Y+L R+ + PE++ P+R+ + + PFG G R Sbjct: 361 VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 420 Query: 449 QCLGRRLAEAEMLLLLHHVLKHFLVETL--TQEDIKMVYSFILRPGTSPLL 497 C+G R A M L L VL++F + TQ +K+ +L+P +L Sbjct: 421 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 471 >6C94-A nrPDB Length = 497 Score = 268 bits (685), Expect = 4e-72, Method: Composition-based stats. Identities = 83/391 (21%), Positives = 157/391 (40%), Gaps = 26/391 (6%) Query: 128 GVFLLNGPEWRFNRLRLNP----DVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGS 183 G+ +L+GP+W +R L P DVL P A+ D ++ + +K + A Sbjct: 103 GLLVLDGPKWFQHRKLLTPGFHYDVLKPYV---------AIFADSTRIMLEKWEKKACEG 153 Query: 184 LTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS 243 + D+ + H ++ FG+ + H SS + + L ++ + + Sbjct: 154 KSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVA-VSELTLLMQQRIDSFQYHND 212 Query: 244 LSRWISPK------VWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKA 297 W++P + + D + + +Q + +H + L ++ Sbjct: 213 FIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAALQDEKEREKIQNRRHLDFLDILLDVRG 272 Query: 298 E----LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISE 353 E LS ++A DTT + L+ +A P+ QQ R+E Sbjct: 273 ESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEVREILGDQDS 332 Query: 354 HPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVL-QNYHIPAGTLVQVFLYSLGR 412 + ++ L +KE RLYP + R +S + +PAG+L+ + +Y+L R Sbjct: 333 FQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSLISLHIYALHR 392 Query: 413 NAALFPRPERYNPQRWLDIRGSGRN-FHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHF 471 N+ ++P PE ++P R+ SGR+ + +PF G R C+G++ A EM ++ L F Sbjct: 393 NSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRF 452 Query: 472 LVETLTQEDIKMVYSFILRPGTSPLLTFRAI 502 + +LR L + + Sbjct: 453 EFSVDPLRLPIKLPQLVLRSKNGIHLYLKPL 483 >6B82-A nrPDB Length = 509 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 88/502 (17%), Positives = 177/502 (35%), Gaps = 41/502 (8%) Query: 24 LGTRAARAPRTVLPFEAMP----QHPGNRWLRLLQIWREQGYEHL-HLEMHQTFQELGPI 78 + + + + +P P L ++ + H+ ++ G + Sbjct: 1 MAKKTSSKGKKQKMNGFVPAGNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDL 60 Query: 79 FRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWR 138 + +G +++ V K + R K F W+ Sbjct: 61 YSLMMGSHKLLIVNNHHHA-KEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWK 119 Query: 139 FNRLRL-NPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTI 197 F+R + + + ++ A + L + +D+ P + Sbjct: 120 FHRKMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSA------VDLGPELTRAVT 173 Query: 198 EASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHF 257 F S ++ + K ++ + W+ K+ Sbjct: 174 NVVCALCFNSSYKRGDAEFESMLQYSQGIVDTVAKDSL------VDIFPWLQIFPNKDLR 227 Query: 258 EAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE--------------LSLEA 303 CI D +QK Y+E + + + LL+A+ L+ + Sbjct: 228 ILRQCI-SIRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDH 286 Query: 304 IKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELP 363 + E+ V+TT L ++ L NP VQ+ +++E + LP Sbjct: 287 VLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLP 346 Query: 364 LLRAALKETLRLYPVGL-FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPER 422 L A + E +R+ PV + V D + Y + GT V + ++SL + + PE Sbjct: 347 YLEATICEVMRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPEL 406 Query: 423 YNPQRWLDIRGSG---RNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQE 479 ++P R+L+ G G + ++PFG G+R CLG LA+ E+ L L +L+ F +E T + Sbjct: 407 FDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQ 466 Query: 480 ---DIKMVYSFILRPGTSPLLT 498 D++ + +L+P ++ Sbjct: 467 PLPDLQGKFGVVLQPKKFKVVA 488 >4WMZ-A nrPDB Length = 539 Score = 247 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 94/479 (19%), Positives = 176/479 (36%), Gaps = 52/479 (10%) Query: 49 WLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHP 108 W+ + G + + + ++ G IF + L G M + P+ E + Sbjct: 62 WIPWVGSAVVYGMKP-YEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLAD- 119 Query: 109 CRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMV-DAVARD 167 + E A+ GV + + L+ +A + ++P++ + V + Sbjct: 120 --VSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKY 177 Query: 168 FSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHAL 227 F + K N R + T+DV + TI ++ +L G+ + + +L+ Sbjct: 178 FRDS--KNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEM----RAKLDTDFAYLY-- 229 Query: 228 EVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYT 287 S + F P + ++ P + EH+ D + + +E N Sbjct: 230 -----SDLDKGFTPIN---FVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDR 281 Query: 288 GIVAELLLKA------ELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILR 341 ++ L+ + +++ + I + + G T+A L LA PDVQQ L Sbjct: 282 DLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELY 341 Query: 342 QESLAAA-ASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQN--YHIP 398 +E + E E+PLL +KETLR++ L R V D+ + N Y IP Sbjct: 342 EEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIP 401 Query: 399 AGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS-----------------GRNFHHV 441 AG V V FP ++N RW + S G + ++ Sbjct: 402 AGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYL 461 Query: 442 PFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLV-----ETLTQEDIKMVYSFILRPGTSP 495 PFG G +C+G A ++ +L+ ++ +T+ D + + P Sbjct: 462 PFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKII 520 >5JLC-A nrPDB Length = 515 Score = 245 bits (624), Expect = 5e-65, Method: Composition-based stats. Identities = 93/479 (19%), Positives = 172/479 (35%), Gaps = 54/479 (11%) Query: 49 WLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHP 108 W+ + G + + ++ G IF + L G M + P+ E + Sbjct: 44 WIPWVGSAIPYGTKP-YEFFEDCQKKYGDIFSFMLLGRIMTVYLGPKGHEFIFNAKLAD- 101 Query: 109 CRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMV-DAVARD 167 + E ++ GV + + L+ +A R++P++ + + + Sbjct: 102 --VSAEAAYSHLTTPVFGKGVIYDCPNHRLMEQKKFVKGALTKEAFVRYVPLIAEEIYKY 159 Query: 168 FSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHAL 227 F + K+ +N G +DV S TI ++ +L G+ + +L+ Sbjct: 160 FRNSKNFKINENNSG--IVDVMVSQPEMTIFTASRSLLGKEM----RDKLDTDFAYLY-- 211 Query: 228 EVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYT 287 S + F P + ++ P + EH+ D Q + +E Sbjct: 212 -----SDLDKGFTPIN---FVFPNLPLEHYRKRDHAQQAISGTYMSLIKERREKNDIQNR 263 Query: 288 GIVAELLLKA------ELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILR 341 ++ EL+ + +++ + I + + G T+A L LA PDVQ+ L Sbjct: 264 DLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELY 323 Query: 342 QESLAAAA-SISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQN--YHIP 398 QE + E +PLL +KETLRL+ L R V D+ + N Y +P Sbjct: 324 QEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSYVVP 383 Query: 399 AGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS------------------GRNFHH 440 V V FP+P +N RW S G + + Sbjct: 384 RDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPY 443 Query: 441 VPFGFGMRQCLGRRLAEAEMLLLLHHVLK----HFLV--ETLTQEDIKMVYSFILRPGT 493 +PFG G +C+G A ++ +L+ ++ + ET+ D + + P Sbjct: 444 LPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGETVPPSDFTSMVTLPTAPAK 502 >4R1Z-A nrPDB Length = 439 Score = 241 bits (615), Expect = 5e-64, Method: Composition-based stats. Identities = 81/398 (20%), Positives = 152/398 (38%), Gaps = 35/398 (8%) Query: 123 RGHKCGVFLLNGPEWRFNRLRL-NPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNAR 181 R K F W+F+R + + + ++ A + L + Sbjct: 40 RDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSA-- 97 Query: 182 GSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMP 241 +D+ P + F S ++ + K ++ Sbjct: 98 ----VDLGPELTRAVTNVVCALCFNSSYKRGDAEFESMLQYSQGIVDTVAKDSL------ 147 Query: 242 RSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE--- 298 + W+ K+ CI D +QK Y+E + + + LL+A+ Sbjct: 148 VDIFPWLQIFPNKDLTILRQCI-SIRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSS 206 Query: 299 -----------LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAA 347 L+ + + ++ V+TT L ++ L NP VQ+ +++E + Sbjct: 207 ENNNSSTRDVGLTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSK 266 Query: 348 AASISEHPQKATTELPLLRAALKETLRLYPVGL-FLERVVSSDLVLQNYHIPAGTLVQVF 406 LP L A ++E LR+ PV + V D + Y + GT V + Sbjct: 267 IGKERHPQLSDRGNLPYLEATIREVLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVIN 326 Query: 407 LYSLGRNAALFPRPERYNPQRWLDIRGSG---RNFHHVPFGFGMRQCLGRRLAEAEMLLL 463 L+SL + + PE ++P R+L+ G G + ++PFG G+R CLG LA+ E+ L Sbjct: 327 LWSLHHDKKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLF 386 Query: 464 LHHVLKHFLVETLTQE---DIKMVYSFILRPGTSPLLT 498 L +L+ F +E T + D++ + +L+P ++ Sbjct: 387 LAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFKVVA 424 >4R20-A nrPDB Length = 486 Score = 241 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 83/484 (17%), Positives = 174/484 (35%), Gaps = 27/484 (5%) Query: 24 LGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL 83 + + + + + ++ R L + + HL Q + GP+F Sbjct: 1 MAKKTSSKGKEGVGSSSVSFPCLPRLPLLGSLLHLRSNLPPHLLFTQLSSQYGPLFGLYA 60 Query: 84 GGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 143 G P + V+ + + + + +G K F P W+ +R Sbjct: 61 G-PHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQGGKDIAFADYSPLWKNHRRL 119 Query: 144 L-NPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNL 202 + + L + + +V A + L A + D+ + Sbjct: 120 VHSSFTLFGEGSNKLQTIVQEAADSLCEEL------QACRGQSSDLSVVLMRAVTNVICR 173 Query: 203 ALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDC 262 +F + + + ++ + + W+ K+ +C Sbjct: 174 LVFSSSY----QPSDPELQTVIQYNDGIVQTIAR--GGLVDIFPWLRIFPNKDLKRLKEC 227 Query: 263 IFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLK--------AELSLEAIKANSMELTAG 314 + +K+ + P ++ LL+ +++ + + + E Sbjct: 228 VSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGGADDITEDHVLMTAAEAFGA 287 Query: 315 SVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLR 374 V+TT+ LL T+ L +P +Q+ ++ E LPLL A L E +R Sbjct: 288 GVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDAVLCEVMR 347 Query: 375 LYPVGLF-LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRG 433 + PV + V D L + +P GT V V ++++ + + +PE++NP+R+L+ G Sbjct: 348 IRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPERFLEPSG 407 Query: 434 SGRN-FHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQE---DIKMVYSFIL 489 + +PFG G R C+G LA E+ L + L+ F ++ D++ + +L Sbjct: 408 KKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPSEASLPDLQGRFGVVL 467 Query: 490 RPGT 493 +P Sbjct: 468 QPER 471 >5UYS-A nrPDB Length = 494 Score = 237 bits (604), Expect = 9e-63, Method: Composition-based stats. Identities = 87/472 (18%), Positives = 176/472 (37%), Gaps = 37/472 (7%) Query: 24 LGTRA-ARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYN 82 + + A+ P+++L ++P +L H+H + ++ GPI+ Sbjct: 1 MAKKTGAKYPKSLL---SLPLVGSLPFLPRHG--------HMHNNFFKLQKKYGPIYSVR 49 Query: 83 LGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNR- 141 +G V V + K + + K F +G W+ +R Sbjct: 50 MGTKTTVIVGH-HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRR 108 Query: 142 LRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSI--------- 192 L + L Q+ ++ L Q+ S + V + Sbjct: 109 LAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT 168 Query: 193 FHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKV 252 + + + G++ + + ++ + L++ T++ + + + K+ Sbjct: 169 SYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKI 228 Query: 253 WKEHFEA--WDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSME 310 + + E D I D +Q ++ + +ELL S I + Sbjct: 229 LENYKEKFRSDSITNMLDTLMQ---AKMNSDNGNAGPDQDSELL-----SDNHILTTIGD 280 Query: 311 LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALK 370 + V+TT + TL L NP V++ L +E L LL A ++ Sbjct: 281 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIR 340 Query: 371 ETLRLYPVGLF-LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWL 429 E LRL PV + + D + + + GT V + L++L N + +P+++ P+R+L Sbjct: 341 EVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 400 Query: 430 DIRGS---GRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQ 478 + G+ + ++PFG G R C+G LA E+ L++ +L+ F +E Sbjct: 401 NPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDD 452 >6DWN-A nrPDB Length = 491 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 82/488 (16%), Positives = 164/488 (33%), Gaps = 37/488 (7%) Query: 24 LGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL 83 + + + + + PG L+ G ++ HL + + Q+ G + + + Sbjct: 1 MAKKTSS--------KGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRI 51 Query: 84 GGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 143 G V V+ D + V + + + G +GP W R Sbjct: 52 GS-TPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRL 110 Query: 144 ----LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEA 199 L ++ ++ ++ L + + G + + Sbjct: 111 AQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNV 170 Query: 200 SNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWIS--PKVWKEHF 257 FG R S + EV+ P + P F Sbjct: 171 ICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG------NPADFIPILRYLPNPSLNAF 224 Query: 258 EAWDC-IFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLK--------AELSLEAIKANS 308 + + + + +++ Y+ + T + E + +LS E I Sbjct: 225 KDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIV 284 Query: 309 MELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAA 368 ++L DT + +L L NP VQ+ +++E + LP + A Sbjct: 285 LDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAF 344 Query: 369 LKETLRLYPVGLF-LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 + ET R F + + D L+ ++IP G V V + + + L+ P + P+R Sbjct: 345 ILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPER 404 Query: 428 WLDIRGSGR---NFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKH--FLVETLTQEDIK 482 +L G+ + + FG G R+C+G +A E+ L L +L+ F V + D+ Sbjct: 405 FLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMT 464 Query: 483 MVYSFILR 490 +Y ++ Sbjct: 465 PIYGLTMK 472 >2HI4-A nrPDB Length = 495 Score = 236 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 92/476 (19%), Positives = 170/476 (35%), Gaps = 25/476 (5%) Query: 33 RTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVM 92 R +P + + P LL G ++ HL + + Q G + + +G V V+ Sbjct: 8 RPRVP-KGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGS-TPVLVL 64 Query: 93 LPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRL----RLNPDV 148 D + V + + + + G +GP W R LN Sbjct: 65 SRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFS 124 Query: 149 LSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGER 208 ++ ++ ++AL ++ + G D + FG+ Sbjct: 125 IASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQH 184 Query: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWD-CIFQYG 267 S N H S L F P R++ P + F+A++ + Sbjct: 185 FPESSDEMLSLVKN-THEFVETASSGNPLDFFPI--LRYL-PNPALQRFKAFNQRFLWFL 240 Query: 268 DNCIQKIYQELAFNRPQHYTGIVAELLLKAE------LSLEAIKANSMELTAGSVDTTAF 321 +Q+ YQ+ N + TG + + K + E I ++ DT Sbjct: 241 QKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTT 300 Query: 322 PLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF 381 + +L L P++Q+ +++E +LP L A + ET R F Sbjct: 301 AISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPF 360 Query: 382 -LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFH- 439 + + D L ++IP V V + + + L+ P + P+R+L G+ N Sbjct: 361 TIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPL 420 Query: 440 ---HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKH--FLVETLTQEDIKMVYSFILR 490 + FG G R+C+G LA+ E+ L L +L+ F V + D+ +Y ++ Sbjct: 421 SEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMK 476 >3TBG-A nrPDB Length = 479 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 84/444 (18%), Positives = 147/444 (33%), Gaps = 24/444 (5%) Query: 70 QTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILE-PWVAYRQHRGHKCG 128 Q + G +F L V V+ + V P G Sbjct: 38 QLRRRFGDVFSLQL-AWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQG 96 Query: 129 VFLLN-GPEWR-FNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTL 186 VFL GP WR R ++ + V A A + R + L Sbjct: 97 VFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLL 156 Query: 187 DVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSR 246 D G R L+ +++ L Sbjct: 157 D------KAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVL-- 208 Query: 247 WISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF-NRPQHYTGIVAELLLKAE------L 299 P + + D + + P+ T + KA+ Sbjct: 209 LHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSF 268 Query: 300 SLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKAT 359 + E ++ +L + + TT+ L L + +PDVQ+ ++QE + Sbjct: 269 NDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQ 328 Query: 360 TELPLLRAALKETLRLYPVGL-FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFP 418 +P A + E R + + + S D+ +Q + IP GT + L S+ ++ A++ Sbjct: 329 AHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWE 388 Query: 419 RPERYNPQRWLDIRGSG-RNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLT 477 +P R++P+ +LD +G + +PF G R CLG LA E+ L +L+HF T Sbjct: 389 KPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPT 448 Query: 478 QED---IKMVYSFILRPGTSPLLT 498 + V++F++ P L Sbjct: 449 GQPRPSHHGVFAFLVSPSPYELCA 472 >5VBU-A nrPDB Length = 476 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 91/462 (19%), Positives = 172/462 (37%), Gaps = 37/462 (8%) Query: 24 LGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL 83 + + + + LP +L LLQ L + + Q+ GPI+R +L Sbjct: 1 MAKKTSS--KGKLP------PLAPGFLHLLQ-------PDLPIYLLGLTQKFGPIYRLHL 45 Query: 84 GGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 143 G +V + +E V EP R + W+ ++ Sbjct: 46 GLQDVVVLNSKRTIE-EAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKL 104 Query: 144 LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203 +L P+V+ + ++F + ++ A+ + ++ T Sbjct: 105 TRSALLLG-IRDSMEPVVEQLTQEFCERMR------AQPGTPVAIEEEFSLLTCSIICYL 157 Query: 204 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWK--EHFEAWD 261 FG+++ + + L+ ++Q++ + L + +P + + + E D Sbjct: 158 TFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRD 216 Query: 262 CI----FQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVD 317 I + + + + +L + +++L G + Sbjct: 217 HIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTE 276 Query: 318 TTAFPLLMTLFELARNPDVQQILRQESLAAAA---SISEHPQKATTELPLLRAALKETLR 374 TTA L + L +P++QQ L++E S S P K LPLL A + E LR Sbjct: 277 TTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLR 336 Query: 375 LYPVGL-FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRG 433 L PV L + + Y IP GT++ L + ++ RP + P R+L+ Sbjct: 337 LRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEP-- 394 Query: 434 SGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVET 475 G+N + FG G R CLG LA E+ ++L +L+ F + Sbjct: 395 -GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP 435 >3QZ1-A nrPDB Length = 496 Score = 220 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 84/439 (19%), Positives = 170/439 (38%), Gaps = 28/439 (6%) Query: 51 RLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDS-LHPC 109 L+ + +L + + Q+LGP++R LG +V + +E+ Sbjct: 32 PLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAG 91 Query: 110 RMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFS 169 R + +Y+ + L + +L L P VD + ++F Sbjct: 92 RPQIP---SYKLVSQRCQDISLGDYSLLWKAHKKLTRSALLLGTRSSMEPWVDQLTQEFC 148 Query: 170 QALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEV 229 + ++ + + +Q T FG + + H+ + + + Sbjct: 149 ERMR------VQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLMKTWD- 201 Query: 230 MFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGI 289 ++Q++ M L + +P +W+ +A + + +++ + + + + T Sbjct: 202 --HWSIQILDMVPFLRFFPNPGLWR-LKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDY 258 Query: 290 VAELLLK-------AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQ 342 + + + + +L + + ++L G +TTA L + L +P++Q+ L++ Sbjct: 259 MLQGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQE 318 Query: 343 ESLAAAA---SISEHPQKATTELPLLRAALKETLRLYPVGL-FLERVVSSDLVLQNYHIP 398 E S S K LPLL A + E LRL PV L + + Y IP Sbjct: 319 ELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIP 378 Query: 399 AGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEA 458 G +V L + ++ +P + P R+L+ G N + FG G R CLG LA Sbjct: 379 EGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEP---GANPSALAFGCGARVCLGESLARL 435 Query: 459 EMLLLLHHVLKHFLVETLT 477 E+ ++L +L+ F + Sbjct: 436 ELFVVLARLLQAFTLLPPP 454 >5YLW-A nrPDB Length = 495 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 95/446 (21%), Positives = 175/446 (39%), Gaps = 26/446 (5%) Query: 44 HPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDV-EKLQQ 102 PG ++ + G H + + GP+ +LG V V PE E L + Sbjct: 29 PPGPFPYPIVGNMLQLGANP-HQVFAKLSKRYGPLMSIHLGSLYTVIVSSPEMAKEILHR 87 Query: 103 VDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVD 162 + R I + A + + + + EWR R + S ++++ Sbjct: 88 HGQVFSGRTIAQAVHACDHDKISMGFLPVAS--EWRDMRKICKEQMFSNQSMEA----SQ 141 Query: 163 AVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLN 222 + R Q L V + + +D++ + F T+ + LF S A++ Sbjct: 142 GLRRQKLQQLLDHVQKCSDSGRAVDIREAAFITTLNLMSATLFS---SQATEFDSKATME 198 Query: 223 FLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQ--------YGDNCIQKI 274 F +E + + + P + D F Y + ++ Sbjct: 199 FKEIIEGVATIVG--VPNFADYFPILRPFDPQGVKRRADVFFGKLLAKIEGYLNERLESK 256 Query: 275 YQELAFNRPQHYTGIVAELLLKAELSLEAIKAN--SMELTAGSVDTTAFPLLMTLFELAR 332 + + IV +++ E L+ ++L G DT + + EL Sbjct: 257 RANPNAPKKDDFLEIVVDIIQANEFKLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVM 316 Query: 333 NPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL-FLERVVSSDLV 391 NPD L+ E + A + A +LP L+A +KE +R++P G L R SD Sbjct: 317 NPDKMARLKAELKSVAGDEKIVDESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQE 376 Query: 392 LQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLD--IRGSGRNFHHVPFGFGMRQ 449 + Y IP GT + + Y++GR+ +++ PE ++P+R+LD I G+++ +PFG G R Sbjct: 377 VNGYLIPKGTQILINAYAIGRDPSIWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRV 436 Query: 450 CLGRRLAEAEMLLLLHHVLKHFLVET 475 C G LA + + ++ +F + Sbjct: 437 CPGMPLATRILHMATATLVHNFDWKL 462 >2VE3-A nrPDB Length = 444 Score = 218 bits (554), Expect = 6e-57, Method: Composition-based stats. Identities = 91/467 (19%), Positives = 168/467 (35%), Gaps = 33/467 (7%) Query: 38 FEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDV 97 ++P PG+ L L + + + Q+ GPIF+ L G V + Sbjct: 8 LNSLPIPPGDFGLPWLG--ETLNFLNDGDFGKKRQQQFGPIFKTRLFGKN-VIFISGALA 64 Query: 98 EKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRF 157 + + W + + G R R L L P+ + + Sbjct: 65 NRFLFTKEQETFQ---ATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFL-PRTLDSY 120 Query: 158 LPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPS 217 LP +D + Q ++ + + P + T + + GE++ Sbjct: 121 LPKMDGI----VQGYLEQWGKANE----VIWYPQLRRMTFDVAATLFMGEKVSQNPQLFP 172 Query: 218 SASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQE 277 F ++ +F + L + A + + I+ Q+ Sbjct: 173 W----FETYIQGLFSLPIPLPNTLFG-----------KSQRARALLLAELEKIIKARQQQ 217 Query: 278 LAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQ 337 + A LSL +K + L +T L L ++ D++ Sbjct: 218 PPSEEDALGILLAARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIR 277 Query: 338 QILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHI 397 + +RQE S E + ++P L L+E LRL P R + D Q +H Sbjct: 278 ERVRQEQNKLQLS-QELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHF 336 Query: 398 PAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS--GRNFHHVPFGFGMRQCLGRRL 455 P G LV + + L+P PE+++P+R+ + F HVPFG G+R+CLG+ Sbjct: 337 PKGWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEF 396 Query: 456 AEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAI 502 A EM L +++ F L +++++V + RP + + ++ Sbjct: 397 ARLEMKLFATRLIQQFDWTLLPGQNLELVVTPSPRPKDNLRVKLHSL 443 >3RWL-A nrPDB Length = 426 Score = 216 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 73/405 (18%), Positives = 134/405 (33%), Gaps = 41/405 (10%) Query: 94 PEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLN-----GPEWRFNRLRLNPDV 148 E ++L++ D +H C + Y + + + + + + ++ + Sbjct: 41 GEYFKRLRKDDPVHYC--ADSAFGPYWSITKYNDIMHVDTNHDIFSSDAGYGGIIIDDGI 98 Query: 149 LSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGER 208 LP A+ R +K V + ++ +I + + GE Sbjct: 99 QKGGDGGLDLPNFIAMDRPRHDEQRKAVSPIVAPANLAALEGTIRERVSKTLDGLPVGEE 158 Query: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGD 268 V + L L + + S + E+WD Sbjct: 159 FDWVDRVSIEITTQMLATLFDFPFEERRKLT---RWSDVTTAAPGGGVVESWDQRKTELL 215 Query: 269 NCIQKIYQELAFNRPQHYTG-IVAELLLKA----ELSLEAIKANSMELTAGSVDTTAFPL 323 C +Q L R G + +L + ++ E N + L G DTT + Sbjct: 216 ECAA-YFQVLWNERVNKDPGNDLISMLAHSPATRNMTPEEYLGNVLLLIVGGNDTTRNSM 274 Query: 324 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 + L +NPD L L+ + E +R + Sbjct: 275 TGGVLALHKNPDQFAKL------------------KANPALVETMVPEIIRWQTPLAHMR 316 Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 R +D L I G V ++ YS R+ + RPE + R R H+ F Sbjct: 317 RTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR-------PRPRQHLSF 369 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFI 488 GFG+ +C+G RLAE ++ +L +L F + E ++ +F+ Sbjct: 370 GFGIHRCVGNRLAEMQLRILWEEILTRFSRIEVMAEPERVRSNFV 414 >6IQ5-A nrPDB Length = 463 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 88/453 (19%), Positives = 149/453 (32%), Gaps = 28/453 (6%) Query: 62 EHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQ 121 + HL + + G +F+ LG + V+ E V + ++R Sbjct: 1 QAAHLSFARLARRYGDVFQIRLGSC-PIVVLNGERAIHQALVQQGSAF-ADRPSFASFRV 58 Query: 122 HRGHKCGVFLLNGPEWRFNR-----LRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKV 176 G + F W+ R + N P++ Q V + AR+ L V Sbjct: 59 VSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALL---V 115 Query: 177 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSA-SLNFLHALEVMFKSTV 235 +A G+ LD +P + FG R S N V S V Sbjct: 116 RGSADGAF-LDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLV 174 Query: 236 QLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVA---- 291 +M + + + + D ++ P+ Sbjct: 175 DVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAE 234 Query: 292 ------ELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESL 345 A L LE + A ++ S DT + L L R PDVQ ++ E Sbjct: 235 KKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELD 294 Query: 346 AAAASISEHPQKATTELPLLRAALKETLRLYPVGL-FLERVVSSDLVLQNYHIPAGTLVQ 404 LP + A L E +R + +++ + YHIP T+V Sbjct: 295 QVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVF 354 Query: 405 VFLYSLGRNAALFPRPERYNPQRWLDIRG---SGRNFHHVPFGFGMRQCLGRRLAEAEML 461 V +S+ + +P PE ++P R+LD G + F G R+C+G L++ ++ Sbjct: 355 VNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLF 414 Query: 462 LLLHHVLKHFLVETLTQEDIKMV--YSFILRPG 492 L + + E KM Y ++P Sbjct: 415 LFISILAHQCDFRANPNEPAKMNFSYGLTIKPK 447 >6HQG-A nrPDB Length = 425 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 75/410 (18%), Positives = 139/410 (33%), Gaps = 41/410 (10%) Query: 98 EKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRF 157 E+L++ D +H E Y + + + E + + VL A Sbjct: 42 ERLRKEDPVHWGVSPHEDVGGYWSVTKYNDIMAVDTNHEVFSSEPTI---VLPDPADDFT 98 Query: 158 LPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPS 217 LPM A+ +K V + ++P I + + GE + V Sbjct: 99 LPMFIAMDPPKHDVQRKTVQPIVAPNHLAYLEPIIRERAGKILDDLPIGEEINWVDKVSI 158 Query: 218 SASLNFLHALEVMFKSTVQLMFMPRSLSR------WISPKVWKEHFEAWDCIFQYGDNCI 271 + L L + + ++ + +EH + Sbjct: 159 ELTTMTLATLFDFPWEDRRKLTFWSDVATSAPESGILGTTDPEEHENLRRQTLFECVDYF 218 Query: 272 QKIYQELAFNRPQHYTGIVAELLLKAE----LSLEAIKANSMELTAGSVDTTAFPLLMTL 327 +++ E P+ + +L E + N + L G DTT + ++ Sbjct: 219 MRLWNERVNAPPKP---DLISMLAHGESTKNMDRMEYLGNLILLIVGGNDTTRNTISGSV 275 Query: 328 FELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVS 387 L +NPD + LR+ L+ A + ET+R ++ R Sbjct: 276 LALHQNPDQDRKLRE------------------NPGLIPAMVSETIRWQTPLAYMRRRAK 317 Query: 388 SDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGM 447 D L I G V ++ S R+ + RP Y +R R H+ FGFG+ Sbjct: 318 RDFELGGKTIREGDKVAMWYVSGNRDEEVIDRPNDYWIER-------PRVRQHLSFGFGV 370 Query: 448 RQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLL 497 +C+G RLAE ++ ++ +L F + ++ SF+ P++ Sbjct: 371 HRCVGNRLAELQLKIIWEEILARFPRLEVVGPPRRVYSSFVKGYEELPVV 420 >6AYB-A nrPDB Length = 466 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 75/439 (17%), Positives = 152/439 (34%), Gaps = 25/439 (5%) Query: 68 MHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHR--GH 125 + ++ G +F + G M + P+ ++ + L YR R Sbjct: 36 IIDNSKKYGDVFTATILGKEMTFLNHPKILDTFFKATDNE-----LSLRDVYRFMRPVFG 90 Query: 126 KCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLT 185 V+ + E +++ L+ + F+ + + + L T Sbjct: 91 TGVVYDADSTERMMEQVKFVSSGLTTARFRVFVDIFEDEIAHKVKELG--------PEGT 142 Query: 186 LDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLS 245 +DV + I ++ L G+ + + + + + L F SL Sbjct: 143 VDVAELMADLIIFTASRCLLGDEVRQYLSEKN-LGKLYHDIDDGIS----PLSFFYPSLP 197 Query: 246 RWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKA--ELSLEA 303 K K E + + +K + L + K EL+ Sbjct: 198 APKRDKARKAVGEIFQELLDKRREEHKKHPERLLDESKMDVVDHLLTQKYKDGQELTDVH 257 Query: 304 IKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELP 363 + T++ TL + N V + +R+E S ++ Sbjct: 258 RIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMD 317 Query: 364 LLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERY 423 L A +KE LR+YP + + R+ + Y IP G ++ V GR + P+ + Sbjct: 318 YLEACMKEALRMYPPLIMIMRMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVF 377 Query: 424 NPQRWLDIRGSGRNFHH--VPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDI 481 +P+R L R F + VPFG G +C+G A ++ ++ +L++F +E + + Sbjct: 378 DPER-LTERKEHEKFKYGAVPFGAGRHKCIGENFALLQVKSIISILLRYFDMEYIGKIPD 436 Query: 482 KMVYSFILRPGTSPLLTFR 500 S ++ P + ++ Sbjct: 437 PSYTSLVVGPSPPTRMRYK 455 >5FSA-A nrPDB Length = 490 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 83/488 (17%), Positives = 170/488 (34%), Gaps = 67/488 (13%) Query: 49 WLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVE-----KLQQV 103 W+ G + + Q+ G +F + L G M + P+ E KL V Sbjct: 12 WIPWFGSAASYG-QQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDV 70 Query: 104 DSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMV-D 162 + + + P + + +F + L D + +R++P + + Sbjct: 71 SAEEAYKHLTTPVFGTGVIYDCPNSRLM---EQKKFAKFALTTD-----SFKRYVPKIRE 122 Query: 163 AVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLG-LVGHSPSSASL 221 + F K+ + G +V + TI ++ +LFG+ + + S + Sbjct: 123 EILNYFVTDESFKLKEKTHG--VANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLY- 179 Query: 222 NFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQ-ELAF 280 S + F P + ++ P + H+ D + K + Sbjct: 180 -----------SDLDKGFTPIN---FVFPNLPLPHYWRRDAAQKKISATYMKEIKLRRER 225 Query: 281 NRPQHYTGIVAELLLKA------ELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNP 334 ++ LL+ + +++ + I + + G T+A L L P Sbjct: 226 GDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKP 285 Query: 335 DVQQILRQESLAAA----ASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDL 390 +Q ++ QE + +++ + +LP + +KETLR++ + R V++ L Sbjct: 286 HLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPL 345 Query: 391 VLQ--NYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRW-------------------- 428 + NY +P G V V + F PE ++P RW Sbjct: 346 RIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDY 405 Query: 429 -LDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSF 487 G + ++PFG G +C+G + A ++ +L + + + YS Sbjct: 406 GFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSS 465 Query: 488 ILRPGTSP 495 ++ T P Sbjct: 466 MVVLPTEP 473 >1UED-A nrPDB Length = 406 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 70/384 (18%), Positives = 130/384 (33%), Gaps = 42/384 (10%) Query: 120 RQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQN 179 Q G++ +L E R + +F+ + L+K + Sbjct: 56 WQAHGYEVVRRILGDHEHFTTRPQFTQSKSGAHVEAQFVGQISTYDPPEHTRLRKMLTPE 115 Query: 180 ARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMF 239 +E + +L +RL L+ SA L L A V + +L+ Sbjct: 116 FTVRRI---------RRMEPAIQSLIDDRLDLLEAEGPSADLQGLFADPVGAHALCELLG 166 Query: 240 MPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQE--LAFNRPQHYTGIVAELLLK- 296 +PR R ++ + + + D+ Y + LA R G++ ++ Sbjct: 167 IPRDDQREFVRRIRRNADLSRGLKARAADSAAFNRYLDNLLARQRADPDDGLLGMIVRDH 226 Query: 297 -AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHP 355 ++ E +K L G V+T A + + L NP ++L + A Sbjct: 227 GDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPEKA-------- 278 Query: 356 QKATTELPLLRAALKETLRLYPVGLFL-ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNA 414 + E +R R+ D+V+ I AG V + R+ Sbjct: 279 ----------ERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDE 328 Query: 415 ALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFL-- 472 AL P P+ + R V FG G+ C+G LA + + + + + F Sbjct: 329 ALTPDPDVLDANRAAVSD--------VGFGHGIHYCVGAALARSMLRMAYQTLWRRFPGL 380 Query: 473 VETLTQEDIKMVYSFILRPGTSPL 496 + E++K +F+ P P+ Sbjct: 381 RLAVPIEEVKYRSAFVDCPDQVPV 404 >3JUS-A nrPDB Length = 461 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 76/459 (16%), Positives = 153/459 (33%), Gaps = 31/459 (6%) Query: 48 RWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLH 107 + L G + + +++ GP+F + + G ++ + L + Sbjct: 18 SPIPFLGHAIAFGKSPIEF-LENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNED 76 Query: 108 PCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARD 167 + G + NP L K + + + A + Sbjct: 77 ---------LNAEDVYSRLTTPVFGKGVAYD----VPNPVFLEQKKMLK-SGLNIAHFKQ 122 Query: 168 FSQALKKKVLQNAR---GSLTLDVQPSIFHYTIEASNLALFGERL-GLVGHSPSSASLNF 223 ++K+ + S +V ++ I ++ L G+ + + + + Sbjct: 123 HVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADL 182 Query: 224 LHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRP 283 +P L + + H E D + IQK Q Sbjct: 183 DGGFSHAAW------LLPGWLPLPSFRRRDRAHREIKDIFY----KAIQKRRQSQEKIDD 232 Query: 284 QHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE 343 T + A L+ + + + L T++ F LAR+ +Q+ E Sbjct: 233 ILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLE 292 Query: 344 SLAAAASISEH-PQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTL 402 +L LL +KETLRL P + + R+ + + Y IP G Sbjct: 293 QKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQ 352 Query: 403 VQVFLYSLGRNAALFPRPERYNPQRWL-DIRGSGRNFHHVPFGFGMRQCLGRRLAEAEML 461 V V R + +NP R+L D SG F +VPFG G +C+G A ++ Sbjct: 353 VCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIK 412 Query: 462 LLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFR 500 + +L+ + + + + Y+ ++ +P++ ++ Sbjct: 413 TIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYK 451 >5H1Z-A nrPDB Length = 407 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 64/394 (16%), Positives = 130/394 (32%), Gaps = 35/394 (8%) Query: 109 CRMILEPWVAYRQHRGHKCGVFLLNGPEWRF--NRLRLNPDVLSPKAVQRFLPMVDAVAR 166 R+ + Y +K + + + P+ + L + + R +PM A+ R Sbjct: 38 HRVEHSDFGPYWSVSSYKPIITVESLPDLYSSAGGITLADFIENNPTDVR-MPMFIAMDR 96 Query: 167 DFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHA 226 ++ V S + + +I T E + + V + L Sbjct: 97 PKHTGQRRTVAPAFTPSEMVRMSDNIRMRTAEVLDSLEWNTPFDWVDTVSVELTTQMLAI 156 Query: 227 LEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHY 286 L + + S W ++ E ++ C + Sbjct: 157 LFDFPWEERRKLTF---WSDWAGDIELVKNEELRLERLRHMYECGGYFQNLWNAKIGKPP 213 Query: 287 TGIVAELLLK----AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQ 342 T + +++ AE+ N + L G DTT + + L PD + L Sbjct: 214 TPDLISMMIHSDAMAEMDQMEFLGNLILLIVGGNDTTRNTMSAVAYGLDLFPDQRAKLEA 273 Query: 343 ESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTL 402 + ++ ++E +R + R + D L+ I AG Sbjct: 274 DP------------------SMIPNTVQEIIRWQTPLAHMRRTATVDSELEGQQIKAGDK 315 Query: 403 VQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLL 462 + ++ S R+ ++F +R R H+ FG G+ +C+G RLAE ++ + Sbjct: 316 LALWYISANRDESVFENADRIIVDR-------PNARRHLAFGHGIHRCVGARLAELQIAV 368 Query: 463 LLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPL 496 LL + K + + E ++ F+ P+ Sbjct: 369 LLEEMAKRRMRVNVLGEPERVAACFVHGYRKLPV 402 >4KPA-A nrPDB Length = 494 Score = 201 bits (510), Expect = 8e-52, Method: Composition-based stats. Identities = 89/468 (19%), Positives = 171/468 (36%), Gaps = 34/468 (7%) Query: 39 EAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVE 98 + MPQ L+ L + + + + ELG IF++ G R+ + + + Sbjct: 27 KEMPQPKTFGELKNLPL---LNTDKPVQALMKIADELGEIFKFEAPG-RVTRYLSSQRLI 82 Query: 99 KLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFL 158 K +S + R G + W+ L P S +A++ + Sbjct: 83 KEACDESRFDKNLSQALKFV-RDFAGDGLFTSWTHEKNWKKAHNILLPS-FSQQAMKGYH 140 Query: 159 PMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERL-GLVGHSPS 217 M+ +A Q ++ ++V + T++ L F R P Sbjct: 141 AMMVDIAVQLVQKWERLNADEH-----IEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPH 195 Query: 218 SASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQE 277 + + AL+ + P + + + ++E + + + + KI + Sbjct: 196 PFITSMVRALDEAMNKLQR--ANPDDPAYDENKRQFQEDIKVMN-------DLVDKIIAD 246 Query: 278 LAFNRPQHYTGIVAELLLKAE-------LSLEAIKANSMELTAGSVDTTAFPLLMTLFEL 330 + Q + + +L + L E I+ + +TT+ L L+ L Sbjct: 247 RKASGEQ--SDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFL 304 Query: 331 ARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDL 390 +NP V Q +E+ K +L + L E LRL+P D Sbjct: 305 VKNPHVLQKAAEEAARVLVD-PVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDT 363 Query: 391 VLQN-YHIPAGTLVQVFLYSLGRNAALF-PRPERYNPQRWLDIRGSGRNFHHVPFGFGMR 448 VL Y + G + V + L R+ ++ E + P+R+ + ++ PFG G R Sbjct: 364 VLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQH-AFKPFGNGQR 422 Query: 449 QCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPL 496 C+G++ A E L+L +LKHF E T ++ + + L+P + Sbjct: 423 ACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVV 470 >5OFQ-A nrPDB Length = 409 Score = 200 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 64/348 (18%), Positives = 120/348 (34%), Gaps = 31/348 (8%) Query: 147 DVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFG 206 S +A++ + + L+ V + ++ I + Sbjct: 69 LFSSKRAMEERQESILMMDPPKHTKLRNLVNKAFTPRAIQHLEGHIEEIADYLLDEVSSK 128 Query: 207 ERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQY 266 E+ +V + + L + L + E F Sbjct: 129 EKFDIVEDFAGPLPIIVIAELLGVPIQDRALFKKYSDDLVSGAENNSDEAFAKMMQKRNE 188 Query: 267 GDNCIQKIYQELAFNRPQHYTGIVAELLLKAE-----LSLEAIKANSMELTAGSVDTTAF 321 G +Q ++E+ R Q+ + LLL+AE L+ E + + L +TT Sbjct: 189 GVIFLQGYFKEIIAERQQNKQEDLISLLLEAEIDGEHLTEEEVLGFCILLLVAGNETTTN 248 Query: 322 PLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF 381 + + + + DVQ +R++ L+ ++ETLR YP Sbjct: 249 LITNGVRYMTEDVDVQNEVRRDI------------------SLVPNLVEETLRYYPPIQA 290 Query: 382 LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHV 441 + R+ + D+ L I G V + S R++A F P+ + R + HV Sbjct: 291 IGRIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR--------KTNPHV 342 Query: 442 PFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFIL 489 FGFG+ CLG LA E + +L+ + + +K + S + Sbjct: 343 SFGFGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDSPFV 390 >3EJB-B nrPDB Length = 404 Score = 200 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 72/432 (16%), Positives = 141/432 (32%), Gaps = 70/432 (16%) Query: 77 PIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGH--KCGVFLLNG 134 PI++ + V E+ + + D+ R L Q H + N Sbjct: 27 PIYKGSFLKYPGWYVTGYEETAAILK-DARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQ 85 Query: 135 PEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFH 194 P+ R R L +P+ + + P + ++ K + Sbjct: 86 PDHRRLR-TLASGAFTPRTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLAS---- 140 Query: 195 YTIEASNLALFGERLGLVG-HSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVW 253 + I +R L + +++F + + + + + Sbjct: 141 FVIANIIGVPEEDREQLKEWAASLIQTIDFTRSRKALTEGNIM----------------- 183 Query: 254 KEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKA----ELSLEAIKANSM 309 +A ++EL R +H + +LLK +L+ E + + Sbjct: 184 --AVQAMA------------YFKELIQKRKRHPQQDMISMLLKGREKDKLTEEEAASTCI 229 Query: 310 ELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAAL 369 L +TT + ++ L ++P+ LR+ L+ A+ Sbjct: 230 LLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPD------------------LIGTAV 271 Query: 370 KETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWL 429 +E LR RV S D+ + I G V + L + R+ ++F P+ ++ R Sbjct: 272 EECLRYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSP 331 Query: 430 DIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFIL 489 + H+ FG G CLG LA E + ++ +L+ L + + F Sbjct: 332 N--------PHLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGF 383 Query: 490 RPGTSPLLTFRA 501 R +TF A Sbjct: 384 RALEELPVTFEA 395 >3EL3-A nrPDB Length = 467 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 88/473 (18%), Positives = 158/473 (33%), Gaps = 31/473 (6%) Query: 29 ARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRM 88 RAP E + LL + L ++ G + R LG + Sbjct: 10 TRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAF--MSQLRDHGDVVRIKLGPKTV 67 Query: 89 VCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDV 148 V PE L H + W + G K GV NGP R R + P Sbjct: 68 YAVTNPELTGALALNPDYH---IAGPLWESLEGLLG-KEGVATANGPLHRRQRRTIQP-A 122 Query: 149 LSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGER 208 A+ + P+++ A AL ++ T+D F + + L R Sbjct: 123 FRLDAIPAYGPIMEEEAH----ALTERWQ----PGKTVDATSESFRVAVRVAARCLL--R 172 Query: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGD 268 + + M++ +++ L R P + + D Sbjct: 173 GQYMDERAERLCVALATVFRGMYR---RMVVPLGPLYRLPLPANRRFNDALADLHL---- 225 Query: 269 NCIQKIYQELAFNRPQHYTGIVAELLLKAE----LSLEAIKANSMELTAGSVDTTAFPLL 324 + +I E + + + A L K + + + I + + +T A ++ Sbjct: 226 -LVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIM 284 Query: 325 MTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLER 384 L LA +P+ +R E A + +L + E +RL P L R Sbjct: 285 WLLQALADHPEHADRIRDEVEAVTGG-RPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTR 343 Query: 385 VVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG-RNFHHVPF 443 ++ L Y IPAG + Y++ R+ + ++P RWL R + + PF Sbjct: 344 RAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPF 403 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPL 496 G R+C + A++ L+ + + E + + + LRP + Sbjct: 404 SAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLV 456 >3S79-A nrPDB Length = 503 Score = 194 bits (493), Expect = 7e-50, Method: Composition-based stats. Identities = 84/468 (17%), Positives = 169/468 (36%), Gaps = 40/468 (8%) Query: 39 EAMPQHP---GNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPE 95 ++P G L + G + G R + G + + Sbjct: 45 SSIPGPGYCMGIGPLISHGRFLWMGIGSACNY---YNRVYGEFMRVWISGEETLIISKSS 101 Query: 96 DVEKLQQ---VDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPE-WRFNRLRLNPDVLSP 151 + + + S ++ L+ H+ G+ N PE W+ R LS Sbjct: 102 SMFHIMKHNHYSSRFGSKLGLQCIGM------HEKGIIFNNNPELWKTTRPFFMK-ALSG 154 Query: 152 KAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGL 211 + R + + + L++ + S +DV + ++ SN Sbjct: 155 PGLVRMVTVCAESLKTHLDRLEEVTNE----SGYVDVLTLLRRVMLDTSNTLFL------ 204 Query: 212 VGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSR--WISPKVWKEHFEAWDCIFQYGDN 269 P S + ++ F + L+ P + W+ K K + D I Sbjct: 205 --RIPLDES-AIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAE 261 Query: 270 CIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFE 329 ++I E + + + +L+ E + +E+ + DT + L LF Sbjct: 262 KRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFL 321 Query: 330 LARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSD 389 +A++P+V++ + +E + +L ++ + E++R PV + R D Sbjct: 322 IAKHPNVEEAIIKEIQTVIGE-RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALED 380 Query: 390 LVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQ 449 V+ Y + GT + + + + R FP+P + + + + + PFGFG R Sbjct: 381 DVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA---KNVPYRYFQPFGFGPRG 436 Query: 450 CLGRRLAEAEMLLLLHHVLKHFLVETLTQ---EDIKMVYSFILRPGTS 494 C G+ +A M +L +L+ F V+TL E I+ ++ L P + Sbjct: 437 CAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDET 484 >5VWS-A nrPDB Length = 393 Score = 191 bits (485), Expect = 6e-49, Method: Composition-based stats. Identities = 75/398 (18%), Positives = 131/398 (32%), Gaps = 44/398 (11%) Query: 107 HPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDV--LSPKAVQRFLPMVDAV 164 + + + + Y R L + + +R RL P + P Sbjct: 29 NEHPVWRDQFGIYHVFRYDDVRQILGDYQTFSSDRTRLMPTAQGFGKGGITMIDP----- 83 Query: 165 ARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFL 224 + ++ + ++P I + G LV H + + Sbjct: 84 --PEHRHQRRLITHAFTPQSISAMEPRIRQIADHLLDELP-GPEFDLVEHFAYPLPVIVI 140 Query: 225 HALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQ 284 L + L R +S +V + +E +R Sbjct: 141 AELLGVPPGDRHLFRTWSD--RLMSLQVENYADPELARTVAAAMTEMNDYLREHCRSRRT 198 Query: 285 HYTGIVAELLLKAE-----LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQI 339 H + L++AE L LE + + L TT + T+ L +P+ ++ Sbjct: 199 HPRDDLLTRLVQAEVEGKRLDLEEVVNTASLLLLAGHLTTTVLIGNTMLCLWDHPEAEKA 258 Query: 340 LRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPA 399 +R + L+ AAL+E+LRL L RV + D+ + IPA Sbjct: 259 VRADP------------------SLIPAALEESLRLRSPFLQAGRVTTRDVTIAGETIPA 300 Query: 400 GTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAE 459 V ++ S + FP PER++ R + H+ FG G+ CLG +L E Sbjct: 301 NRFVMAWILSANHDDRRFPDPERFDLHR--------QTTGHIAFGHGVHFCLGAQLGRLE 352 Query: 460 MLLLLHHVLKHF-LVETLTQEDIKMVYSFILRPGTSPL 496 + L +L F + +E I S I P+ Sbjct: 353 GRIALERLLGRFTEIHPWPREGISFYQSAIFGASRMPV 390 >5FYF-A nrPDB Length = 470 Score = 191 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 68/421 (16%), Positives = 130/421 (30%), Gaps = 59/421 (14%) Query: 99 KLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLN----GPEWRFNRLRLNPDVLSPKAV 154 L+ +D +P W AY + + V GP W R V + Sbjct: 64 ALEDIDVSNPFLYRQGQWRAYFKRLRDEAPVHYQKNSPFGPFWSVTRFEDILFVDKSHDL 123 Query: 155 QRFLP--------------MVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEAS 200 P M A+ + V +++ I T + Sbjct: 124 FSAEPQIILGDPPEGLSVEMFIAMDPPKHDVQRSSVQGVVAPKNLKEMEGLIRSRTGDVL 183 Query: 201 NLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAW 260 + + V + L L + S ++ E Sbjct: 184 DSLPTDKPFNWVPAVSKELTGRMLATLLDFPYEERHKL---VEWSDRMAGAASATGGEFA 240 Query: 261 DCIFQYGDNC-IQKIYQELAFNRP------QHYTGIVAELLLKAELSLEAIK------AN 307 D + D + + + L ++ + + LL + + + I N Sbjct: 241 DENAMFDDAADMARSFSRLWRDKEARRAAGEEPGFDLISLLQSNKETKDLINRPMEFIGN 300 Query: 308 SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRA 367 L G DTT + L + P + L + L+ Sbjct: 301 LTLLIVGGNDTTRNSMSGGLVAMNEFPREFEKL------------------KAKPELIPN 342 Query: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 + E +R ++ R+ D+ L I G V ++ S R+ F P+++ R Sbjct: 343 MVSEIIRWQTPLAYMRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFIIDR 402 Query: 428 WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSF 487 +H+ FG+G+ +C+G RLAE ++ +L +LK F + +E ++ +F Sbjct: 403 -------KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFDNIEVVEEPERVQSNF 455 Query: 488 I 488 + Sbjct: 456 V 456 >4RM4-A nrPDB Length = 396 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 57/335 (17%), Positives = 110/335 (32%), Gaps = 37/335 (11%) Query: 151 PKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLG 210 P+ + + ++ V + + +P I T E Sbjct: 71 PQQTSSIGNSIINMDPPKHTKIRSVVNKAFTPRVMKQWEPRIQEITDELIQKFQGRSEFD 130 Query: 211 LVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNC 270 LV + + L + + M ++ S + + EA + D C Sbjct: 131 LVHDFSYPLPVIVISELLGVPSAH---MEQFKAWSDLLVSTPKDKSEEAEKAFLEERDKC 187 Query: 271 IQK---IYQELAFNRPQHYTGIVAELLLKAELSLEAIKAN-----SMELTAGSVDTTAFP 322 ++ + + + + +L++AE + E + L +TT Sbjct: 188 EEELAAFFAGIIEEKRNKPEQDIISILVEAEETGEKLSGEELIPFCTLLLVAGNETTTNL 247 Query: 323 LLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382 + ++ + P V + LR + L+ A++E LR L Sbjct: 248 ISNAMYSILETPGVYEELR------------------SHPELMPQAVEEALRFRAPAPVL 289 Query: 383 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVP 442 R+ D + + I G +V F+ S R+ A F RP ++ +R + H+ Sbjct: 290 RRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRRHPN--------PHIA 341 Query: 443 FGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLT 477 FG G+ CLG LA E + L ++ F Sbjct: 342 FGHGIHFCLGAPLARLEANIALTSLISAFPHMECV 376 >3L4D-A nrPDB Length = 453 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 74/446 (16%), Positives = 148/446 (33%), Gaps = 27/446 (6%) Query: 51 RLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCR 110 + + G + L M + ++ G IF N+ G R+ V DV + + + Sbjct: 13 PFVGHIIQFGKDPLGF-MLKAKKKYGGIFTMNICGNRITVVG---DVHQHSKFFTPRNEI 68 Query: 111 MILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQ 170 + ++ + + P R L ++ K Q F P + R F Sbjct: 69 LSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTVAK-FQNFAPSIQHEVRKF-- 125 Query: 171 ALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVM 230 +K ++ +++ I + LFGE L + F L M Sbjct: 126 -MKANWNKDE---GEINILDDCSAMIINTACQCLFGEDL----RKRLD-ARQFAQLLAKM 176 Query: 231 FKSTVQLMFMPRSLSRWISPKV--WKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTG 288 + + + P+ ++ I +K + N G Sbjct: 177 ESCLIPAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNTSDLLAG 236 Query: 289 IVAELLLKA-ELSLEAIKANSMELTAGSVDTTAFPLLMTLFELA--RNPDVQQILRQESL 345 ++ + +S + + T+ +L L RN L QE Sbjct: 237 LLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEID 296 Query: 346 AAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQV 405 A ++ E+P +E++R P + L R V + + Y +P G ++ Sbjct: 297 EFPAQLNYD--NVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIAC 354 Query: 406 FLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLH 465 ++ FP P +NP+R + + FG G+ +C+G + ++ +L Sbjct: 355 SPLLSHQDEEAFPNPREWNPERNMKLVDGA----FCGFGAGVHKCIGEKFGLLQVKTVLA 410 Query: 466 HVLKHFLVETLTQEDIKMVYSFILRP 491 VL+ + E L ++ ++ P Sbjct: 411 TVLRDYDFELLGPLPEPNYHTMVVGP 436 >2WX2-A nrPDB Length = 473 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 73/422 (17%), Positives = 147/422 (34%), Gaps = 32/422 (7%) Query: 78 IFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHR--GHKCGVFLLNGP 135 +F ++GG R+ V P + + P IL P Y + + P Sbjct: 53 VFTISIGGQRVTIVGDPHEHSRFFS-----PRNEILSPREVYTIMTPVFGEGVAYAAPYP 107 Query: 136 EWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHY 195 R L ++ K Q F+P + R F + + ++ +++ Sbjct: 108 RMREQLNFLAEELTIAK-FQNFVPAIQHEVRKF---MAENWKEDE---GVINLLEDCGAM 160 Query: 196 TIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKV--W 253 I + LFGE L + +F L M S + L R P+ Sbjct: 161 IINTACQCLFGEDL-----RKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPQSARC 215 Query: 254 KEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKA-ELSLEAIKANSMELT 312 +E I +K N G++ + +SL + + Sbjct: 216 REARAELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAM 275 Query: 313 AGSVDTTAFPLLMTLFELAR--NPDVQQILRQESLAAAASISEHPQKATTELPLLRAALK 370 T+ ++ L N L +E A ++ E+P ++ Sbjct: 276 FAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYD--NVMDEMPFAERCVR 333 Query: 371 ETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLD 430 E++R P L + R+V +++ + +Y +P G ++ + FP P ++P+R Sbjct: 334 ESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEK 393 Query: 431 IRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQE-DIKMVYSFIL 489 + G + FG G+ +C+G++ A ++ +L + + + L E ++ ++ Sbjct: 394 VDG-----AFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVV 448 Query: 490 RP 491 P Sbjct: 449 GP 450 >6CR2-A nrPDB Length = 477 Score = 187 bits (475), Expect = 8e-48, Method: Composition-based stats. Identities = 80/463 (17%), Positives = 151/463 (32%), Gaps = 58/463 (12%) Query: 49 WLRLLQIWREQGYEHLHLEMHQTFQELGPIFR-YNLGGPRMVCVML-PEDVEKLQQVDSL 106 W + G + + + G IF LG V + D ++ + Sbjct: 12 WFPFIGSTISYGIDP-YKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFILNGKLRDV 70 Query: 107 HPCRMILEPWV-AYRQHRGHKCGVFLLNGPEWR-FNRLRLNPDVLSPKAVQRFLPMVDAV 164 + + +H + C P + + + L+ A++ ++P++ Sbjct: 71 CAEEVYSPLTTPVFGRHVVYDC-------PNAKLMEQKKFVKYGLTSDALRSYVPLITDE 123 Query: 165 ARDFSQALKKKVLQNARG-SLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNF 223 F K +G DV +I TI ++ +L G+ V S Sbjct: 124 VESFV-----KNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKE---VRSKFDSTFAEL 175 Query: 224 LHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRP 283 H + + F P + ++ P H D + +I + Sbjct: 176 YH--------NLDMGFAPIN---FMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQAGS 224 Query: 284 QHYTGIVAELLLK------AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQ 337 + + + L+ + E I + L +++ + LA PD+ Sbjct: 225 KKDSEDMVWNLMSCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIM 284 Query: 338 QILRQESLAAAASISEH-PQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQN-- 394 + L QE + S +L L +KETLRL+ + R V + + + Sbjct: 285 EELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTS 344 Query: 395 YHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLD-----------------IRGSGRN 437 Y IP V R+ FP P +NP RW + + G N Sbjct: 345 YVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTN 404 Query: 438 FHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED 480 ++PFG G +C+G + A ++ + +++ F L D Sbjct: 405 SPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVD 447 >5L94-A nrPDB Length = 410 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 60/334 (17%), Positives = 116/334 (34%), Gaps = 38/334 (11%) Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALE 228 ++ V + +P I T E E + +V H + + + Sbjct: 92 HAEMRALVNKAFTPKAMKAWEPKIARITNELLQEVEHLEDIDIVEHLSYPLPVMVIADIL 151 Query: 229 VMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTG 288 + + + +E E ++ ++ + + + Sbjct: 152 GVPIEDQRQFKDWSDIIVAGPSNNERETLEKLQQEKMKANDELETYFYRIIEEKRTRPGD 211 Query: 289 IVAELLLKAE-----LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE 343 + +LL+A+ L+ E I S+ L +TT + T++ L + + L++E Sbjct: 212 DIISVLLQAKEEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIYCLMEDKASFERLKRE 271 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLV 403 LL + ++E LR L R+V D+ L + AG V Sbjct: 272 KE------------------LLPSGIEEVLRYRSPVQALHRIVKEDVTLAGKKLKAGEHV 313 Query: 404 QVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLL 463 ++ S R+A F PE + R ++ H+ FG G+ CLG LA E ++ Sbjct: 314 VPWMGSAHRDAEYFEDPEVFKIDRKPNV--------HMAFGRGIHFCLGAPLARIEAKIM 365 Query: 464 LHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLL 497 L ++ + + SF L+P S + Sbjct: 366 LAELIDRYP-------QMDWSPSFELKPIESTFV 392 >2W0A-A nrPDB Length = 455 Score = 184 bits (466), Expect = 8e-47, Method: Composition-based stats. Identities = 80/445 (17%), Positives = 152/445 (34%), Gaps = 40/445 (8%) Query: 68 MHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKC 127 M + ELG + + L G ++V + E + + P++ Sbjct: 30 MQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMT----PIFGE 85 Query: 128 GVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLD 187 V PE + L+ L + ++ ++ R +++ + + +D Sbjct: 86 AVVFDASPE--RRKEMLHNAALRGEQMKGHAATIEDQVR--------RMIADWGEAGEID 135 Query: 188 VQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRW 247 + TI S+ L G++ F + + T L + Sbjct: 136 LLDFFAELTIYTSSACLIGKKFR------DQLDGRFAKLYHELERGTDPLA--------Y 181 Query: 248 ISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTG-IVAELLLKAE-------L 299 + P + E F D + I N P + + ++L+ + Sbjct: 182 VDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRF 241 Query: 300 SLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKAT 359 S + I + + T++ TL EL R+ D + E A Sbjct: 242 SADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHAL 301 Query: 360 TELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPR 419 ++P L LKETLRL+P + L RV + +Q + I G LV R FP Sbjct: 302 RQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPD 361 Query: 420 PERYNPQRWLDIRGSG--RNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVE-TL 476 P + P R+ R + +PFG G +C+G A ++ + +L+ + E Sbjct: 362 PHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQ 421 Query: 477 TQEDIKMVYS-FILRPGTSPLLTFR 500 E + +S +++ + +R Sbjct: 422 PPESYRNDHSKMVVQLAQPAAVRYR 446 >6HQD-A nrPDB Length = 420 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 66/429 (15%), Positives = 126/429 (29%), Gaps = 58/429 (13%) Query: 98 EKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLN----GPEWRFNRLR---------- 143 L+ +D P + Y + + V GP W + Sbjct: 16 IALEDIDVSKPELFERDGLHPYFERLRREDPVHYCKASEYGPYWSITKFSDIVAIDTNHK 75 Query: 144 ------------LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPS 191 L+ L+ +LP + + V L + + Sbjct: 76 VFSSDHTNGSFVLDDTTLNAVDGGIYLPNFLGMDPPKHDVHRMVVSPIVAPQNLLRFEAT 135 Query: 192 IFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPK 251 I T + GE V + L L + + S I+ + Sbjct: 136 IRERTKRVLSELPIGEEFNWVDRVSIELTTMMLATLLDFPFDDRRKLT---RWSDIITTR 192 Query: 252 VWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKA----ELSLEAIKAN 307 ++W+ C+ + A + + +L + +L+ Sbjct: 193 PGYGLVDSWEQRESELMECLAYFQRLYAERQAMPPKPDLISMLAHSPEMQDLTPTDFLGT 252 Query: 308 SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRA 367 L G DTT + + P +R LL + Sbjct: 253 LALLIVGGNDTTRSSMSGSAMACHLYPQEFDKVR------------------NNRALLAS 294 Query: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 + E +R + R D+ + I G V ++ S R+ + RP + R Sbjct: 295 VIPEVVRWQTPIAHMRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDFIADR 354 Query: 428 WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSF 487 R HH+ FGFG+ +CLG RLAE ++ +L + + + + E +++ + Sbjct: 355 -------PRARHHLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPVRVPSNL 407 Query: 488 ILRPGTSPL 496 + P+ Sbjct: 408 VHGYIDIPV 416 >2XKR-A nrPDB Length = 398 Score = 181 bits (459), Expect = 7e-46, Method: Composition-based stats. Identities = 67/325 (20%), Positives = 117/325 (36%), Gaps = 28/325 (8%) Query: 158 LPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPS 217 LPM+ + +K V D + SI + V + Sbjct: 72 LPMMIDMDDPAHLLRRKLVNAGFTRKRVKDKEASIAALCDTLIDAVCERGECDFVRDLAA 131 Query: 218 SASLNFL-HALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFE-AWDCIFQYGDNCIQKIY 275 + + L V + + L ++S V +E F+ D Y D I Sbjct: 132 PLPMAVIGDMLGVRPEQRDMFLRWSDDLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIA 191 Query: 276 QELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPD 335 A + +V+ + LS + + ++ + G +TT L +L RN D Sbjct: 192 ARRADPTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRD 251 Query: 336 VQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNY 395 +L+++ LL A++E LR + RV+++D Sbjct: 252 QWDLLQRDP------------------SLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGT 293 Query: 396 HIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRL 455 + AG + + S + A+F PE+++ QR + H+ FGFG CLG +L Sbjct: 294 ALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPN--------SHLAFGFGTHFCLGNQL 345 Query: 456 AEAEMLLLLHHVLKHFLVETLTQED 480 A E+ L+ VL+ L +D Sbjct: 346 ARLELSLMTERVLRRLPDLRLVADD 370 >4TRI-A nrPDB Length = 407 Score = 181 bits (458), Expect = 8e-46, Method: Composition-based stats. Identities = 62/344 (18%), Positives = 119/344 (34%), Gaps = 30/344 (8%) Query: 158 LPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPS 217 +P + + +K V +D SI + V + Sbjct: 75 MPYMIDMDDPQHLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAA 134 Query: 218 SASLNFL-HALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEA-WDCIFQYGDNCIQKIY 275 + + L V+ L+ L +S V + + D Y + I Sbjct: 135 PLPMAVIGDMLGVLPTERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVIT 194 Query: 276 QELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPD 335 + A ++ +V + +S + I ++ + G +TT L +L R+ D Sbjct: 195 KRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRD 254 Query: 336 VQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNY 395 L ++ LL A++E LR + R +++D V Sbjct: 255 QWDAL------------------VADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGT 296 Query: 396 HIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRL 455 + AG + + S + ++F P+ + R + HV FGFG CLG +L Sbjct: 297 ELRAGEKIMLMFESANFDESVFGDPDNFRIDRNPN--------SHVAFGFGTHFCLGNQL 348 Query: 456 AEAEMLLLLHHVLKHFLVETLTQE-DIKMVY-SFILRPGTSPLL 497 A E+ L+ VL+ L + + + +F+ P + P++ Sbjct: 349 ARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVV 392 >5LIV-A nrPDB Length = 450 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 66/346 (19%), Positives = 124/346 (35%), Gaps = 39/346 (11%) Query: 163 AVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE-RLGLVGHSPSSASL 221 A+ D +++ + E L G+ R+ L+ Sbjct: 125 AMQGDEHARMRRVYNMFFLPRAVSQYEERFVRPISEQVVDRLAGKPRVDLLEDFAMELPR 184 Query: 222 NFLHAL-----EVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQ 276 + L E + ++ ++ M R L R P E A+ +++ + Sbjct: 185 RVIGELFGFPAEKLHETDERVRAMLRGLVRMHDPAAVAESQRAYGETLGLITEVVERESR 244 Query: 277 ELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDV 336 + + I+ L + ++EA + + L G +TT++ + T+ L +PD Sbjct: 245 DTSDT---LLGEILRTLKAEHMDTIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDT 301 Query: 337 QQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYH 396 +RQ+ LL AA++E +R P + R+V D+ L + Sbjct: 302 LARVRQDP------------------SLLPAAIEEGMRWCPSSFGVLRMVERDVRLDDQA 343 Query: 397 IPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLA 456 + AGT+V + + + +P PE Y+ R + FG G C+G LA Sbjct: 344 LSAGTVVCLAGIAGNYDETAYPSPEVYDIDRKPLPAANV-------FGGGAHFCVGAPLA 396 Query: 457 EAEMLLLLHHVLKHFL-VETLTQEDIKMVYSFIL----RPGTSPLL 497 E + L +L F + + +E +Y P P+L Sbjct: 397 RMEARVGLQALLARFPGLRAVPEERPSFMYGAKDSVAHGPDKLPVL 442 >6F88-A nrPDB Length = 400 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 61/300 (20%), Positives = 113/300 (37%), Gaps = 38/300 (12%) Query: 208 RLGLVGHSPSSASLNFLHAL-----EVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDC 262 R+ L+ + L E + ++ ++ M R L R P E A+ Sbjct: 121 RVDLLEDFAMELPRRVIGELFGFPAEKLHETDERVRAMLRGLVRMHDPAAVAESQRAYGE 180 Query: 263 IFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFP 322 +++ ++ + I+ L + ++EA + + L G +TT++ Sbjct: 181 TLGLITEVVERESRDTSDT---LLGEILRTLKAEHMDTIEASRQIVLSLILGGYETTSWL 237 Query: 323 LLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382 + T+ L +PD +RQ+ LL AA++E +R P + Sbjct: 238 VANTIHALLAHPDTLARVRQDP------------------SLLPAAIEEGMRWCPSNFGV 279 Query: 383 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVP 442 R+V D+ L + + AGT+V + + + +P PE Y+ R + Sbjct: 280 LRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRKPLPAANV------- 332 Query: 443 FGFGMRQCLGRRLAEAEMLLLLHHVLKHFL-VETLTQEDIKMVYSFIL----RPGTSPLL 497 FG G C+G LA E + L +L F + + +E +Y P P+L Sbjct: 333 FGGGAHFCVGAPLARMEARVGLQALLARFPGLRAVPEERPSFMYGAKDSVAHGPDKLPVL 392 >2WIO-A nrPDB Length = 431 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 60/344 (17%), Positives = 109/344 (31%), Gaps = 31/344 (9%) Query: 160 MVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSA 219 M+ + +AL+K V D++P I T A GE LV Sbjct: 106 MIHEIDPPEHRALRKVVSSAFTPRTISDLEPRIRDVTRSLLADA--GESFDLVDVLAFPL 163 Query: 220 SLNFLHALEVMFKSTVQLMFMPRS---LSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQ 276 + + L + + + P D + + + Sbjct: 164 PVTIVAELLGLPPMDHEQFGDWSGALVDIQMDDPTDPALAERIADVLNPLTAYLKARCAE 223 Query: 277 ELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDV 336 A + +V + L E S L TT L + L +P Sbjct: 224 RRADPGDDLISRLVLAEVDGRALDDEEAANFSTALLLAGHITTTVLLGNIVRTLDEHPAH 283 Query: 337 QQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYH 396 ++ + A ++E LR P ++R + + Sbjct: 284 WDAAAEDPGR------------------IPAIVEEVLRYRPPFPQMQRTTTKATEVAGVP 325 Query: 397 IPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLA 456 IPA +V ++ S R++ P+R++P R + FG G+ CLG LA Sbjct: 326 IPADVMVNTWVLSANRDSDAHDDPDRFDPSR------KSGGAAQLSFGHGVHFCLGAPLA 379 Query: 457 EAEMLLLLHHVLKHFLVETLTQEDIKMVY--SFILRPGTSPLLT 498 E + L ++ F T+ ++D ++ + +L P+L Sbjct: 380 RLENRVALEEIIARFGRLTVDRDDERLRHFEQIVLGTRHLPVLA 423 >2WM5-A nrPDB Length = 435 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 60/356 (16%), Positives = 127/356 (35%), Gaps = 39/356 (10%) Query: 150 SPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFG--- 206 +P+ + F M+ + Q L+ V + + ++ ++ + + Sbjct: 107 TPELAEYFGSMI-VLDDPRHQRLRSIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPD 165 Query: 207 ERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQY 266 + LV L + + + K+ Q +F ++ F+ F Sbjct: 166 RQADLVSELAGPLPLQIICDMMGIPKADHQRIFHWTNVILGFGDPDLATDFDE----FMQ 221 Query: 267 GDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLE-----AIKANSMELTAGSVDTTAF 321 I LA +R ++ + L++AE+ E I + + L +TT Sbjct: 222 VSADIGAYATALAEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRN 281 Query: 322 PLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF 381 + + L+R P+ + + L A++E +R ++ Sbjct: 282 AITHGVLALSRYPEQRDR-----------------WWSDFDGLAPTAVEEIVRWASPVVY 324 Query: 382 LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHV 441 + R ++ D+ L+ + AG V ++ S R+ + F P ++ R + H+ Sbjct: 325 MRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPN--------PHL 376 Query: 442 PF-GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPL 496 F G G CLG LA E+ + + + T+E +++ FI T P+ Sbjct: 377 GFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPV 432 >2X2N-A nrPDB Length = 475 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 73/432 (16%), Positives = 145/432 (33%), Gaps = 31/432 (7%) Query: 78 IFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR--QHRGHKCGVFLLNGP 135 IF N+ G R+ V P + + P +L P Y + + P Sbjct: 53 IFTINIVGKRVTIVGDPHEHSRFFL-----PRNEVLSPREVYSFMVPVFGEGVAYAAPYP 107 Query: 136 EWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHY 195 R L ++ K Q F+P + R F + ++ +++ Sbjct: 108 RMREQLNFLAEELTIAK-FQNFVPAIQHEVRKF---MAANWDKDE---GEINLLEDCSTM 160 Query: 196 TIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ--LMFMPRSLSRWISPKVW 253 I + LFGE L + F L M S + + Sbjct: 161 IINTACQCLFGEDL-----RKRLDARRFAQLLAKMESSLIPAAVFLPILLKLPLPQSARC 215 Query: 254 KEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKA-ELSLEAIKANSMELT 312 E I + + +G+++ + +SL + + Sbjct: 216 HEARTELQKILSEIIIARKAAAVNKDSSTSDLLSGLLSAVYRDGTPMSLHEVCGMIVAAM 275 Query: 313 AGSVDTTAFPLLMTLFELAR--NPDVQQILRQESLAAAASISEHPQKATTELPLLRAALK 370 T++ ++ L N + LR+E A ++ + E+P + Sbjct: 276 FAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNYN--NVMDEMPFAERCAR 333 Query: 371 ETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLD 430 E++R P L L R V +D+ + +Y +P G ++ + FP P R++P+R Sbjct: 334 ESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPERDEK 393 Query: 431 IRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILR 490 + G + FG G+ +C+G++ ++ +L + + + L E Y ++ Sbjct: 394 VEG-----AFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPDPDYHTMVV 448 Query: 491 PGTSPLLTFRAI 502 T+ + I Sbjct: 449 GPTASQCRVKYI 460 >1CPT-A nrPDB Length = 428 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 53/329 (16%), Positives = 109/329 (33%), Gaps = 38/329 (11%) Query: 180 ARGSLTLDVQPSIFHYTIEASNLAL-FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM 238 + + ++ +I + L F + L+ + + + LM Sbjct: 121 FQPASIRKLEENIRRIAQASVQRLLDFDGECDFMTDCALYYPLHVVMTALGVPEDDEPLM 180 Query: 239 -FMPRSLSRWISPKVWKEH--FEAWDCIFQYGDNCIQKIYQ---ELAFNRPQHYTGIVAE 292 + + P ++ D + I Y +R V Sbjct: 181 LKLTQDFFGVHEPDEQAVAAPRQSADEAARRFHETIATFYDYFNGFTVDRRSCPKDDVMS 240 Query: 293 LLLKAELS-----LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAA 347 LL ++L + I A + + DTT+ + L+RNP+ + Sbjct: 241 LLANSKLDGNYIDDKYINAYYVAIATAGHDTTSSSSGGAIIGLSRNPEQLAL-------- 292 Query: 348 AASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFL 407 A ++ L+ + E +R R +D ++ +I G + + Sbjct: 293 ----------AKSDPALIPRLVDEAVRWTAPVKSFMRTALADTEVRGQNIKRGDRIMLSY 342 Query: 408 YSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHV 467 S R+ +F P+ ++ R+ + H+ FG+G CLG+ LA+ EM + + Sbjct: 343 PSANRDEEVFSNPDEFDITRFPN--------RHLGFGWGAHMCLGQHLAKLEMKIFFEEL 394 Query: 468 LKHFLVETLTQEDIKMVYSFILRPGTSPL 496 L L+ + +F+ P P+ Sbjct: 395 LPKLKSVELSGPPRLVATNFVGGPKNVPI 423 >2ZBZ-A nrPDB Length = 412 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 88/464 (18%), Positives = 149/464 (32%), Gaps = 91/464 (19%) Query: 42 PQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQ 101 P P NR L Q GP+ R L R V+ + + Sbjct: 14 PAFPSNRSCPY----------QLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKL 63 Query: 102 ---------QVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPK 152 + D P A+ R L+ PE R R+ + K Sbjct: 64 LGDPRLSSNRTDDNFPATSP-----AFEAVRESPQAFIGLDPPE-HGTRRRMTISEFTVK 117 Query: 153 AVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLV 212 ++ P V+ V F + G LV Sbjct: 118 RIKGMRPEVEEVVHGFLDEMLAA------------------------------GPTADLV 147 Query: 213 GHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQ 272 + L + + + F + R + + A + + Y D I Sbjct: 148 SQFALPVPSMVICRLLGVPYADHE--FFQDASKRLVQSTDAQSALTARNDLAGYLDGLIT 205 Query: 273 KIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELAR 332 + E +VA+ L E+ E + + +M L +TTA +++ L Sbjct: 206 QFQTEPGAG---LVGALVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLD 262 Query: 333 NPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL-ERVVSSDLV 391 +P+ LR + L+ A++E LR + RV ++D+ Sbjct: 263 HPEQYAALRADR------------------SLVPGAVEELLRYLAIADIAGGRVATADIE 304 Query: 392 LQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCL 451 ++ I AG V V R+ ++ P+ + R HH+ FGFG+ QCL Sbjct: 305 VEGQLIRAGEGVIVVNSIANRDGTVYEDPDALDIHRSA--------RHHLAFGFGVHQCL 356 Query: 452 GRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSP 495 G+ LA E+ ++L+ ++ L V +LRPGT+ Sbjct: 357 GQNLARLELEVILNALMDRVPTLRLAV----PVEQLVLRPGTTI 396 >6GMF-A nrPDB Length = 397 Score = 174 bits (442), Expect = 5e-44, Method: Composition-based stats. Identities = 70/414 (16%), Positives = 133/414 (32%), Gaps = 71/414 (17%) Query: 91 VMLPEDVEKLQQVDSLHPCRMILE--PWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDV 148 V +DV ++ R P V + P L Sbjct: 40 VGRYQDVARVLHDAKGFSNRGWAASLPRGVKWDTSMPPSIVQV--DPPRHGKLRTLVTKA 97 Query: 149 LSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGER 208 +P+ V + P + +A + L+ + + V+ ++ I + + Sbjct: 98 FTPRTVAQLEPRIRDIAHELVDGLR------GKSTFEATVEVTVPMPMIVIAEMLGVAPE 151 Query: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGD 268 S + L + V + ++ + + Y Sbjct: 152 RRADFKRWSDDMVGSLALVRVGNAAQLE---------------------RSTQEFYAY-- 188 Query: 269 NCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSME-----LTAGSVDTTAFPL 323 + E+ R + + LL AE+ E + A + L +TT + Sbjct: 189 ------FSEVLEERRREPREDLISQLLAAEVDGEKLTAGEVLSFANTLLIAGNETTTSLI 242 Query: 324 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 L L +P+ + + L L+ A ++E LR + Sbjct: 243 GNALVALTDHPEQLAAAQAD------------------LSLVPAVVEEVLRYESPAQCIF 284 Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 R +D+ + + IPA ++V L S R+ + FP P+R++ R H+ F Sbjct: 285 RQTMTDVEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHR--------DTKGHLAF 336 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILR-PGTSPL 496 G + C+G LA E ++L +L +++ SF +R P T PL Sbjct: 337 GLDIHFCIGAPLARLEAKVMLEVLLARLGDIQRVSQEVSWSPSFFIRSPSTLPL 390 >6B11-A nrPDB Length = 440 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 59/274 (21%), Positives = 104/274 (37%), Gaps = 31/274 (11%) Query: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGD 268 L + A L AL + + +L+ +P + + + A Sbjct: 169 LDDLTARGDEADLLADFALPMATQVICRLLDIPYEDRDYFQERTEQATRPAAGEEALEAL 228 Query: 269 NCIQKIYQELA--FNRPQHYTGIVAELLLKAE---LSLEAIKANSMELTAGSVDTTAFPL 323 ++ L + G++ ++ +A LS + N++ L A +TTA + Sbjct: 229 LELRDYLDRLISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMV 288 Query: 324 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 M++ L ++P + L T LL A+ E LR + L Sbjct: 289 TMSVLVLLQHPTAWREL------------------TVNPGLLPGAVDELLRYLSIADGLR 330 Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 R ++D+ + + I AG + L + R+ A+F PE ++ R HV F Sbjct: 331 RSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSA--------RRHVAF 382 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLT 477 G+G QCLG+ LA E+ + L VL+ T Sbjct: 383 GYGPHQCLGQNLARMELEVALGAVLERLPALRPT 416 >5LIE-A nrPDB Length = 414 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 61/326 (18%), Positives = 110/326 (33%), Gaps = 35/326 (10%) Query: 160 MVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSA 219 +++ + +++ V + V+ + + G V + Sbjct: 94 VLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAPFDFVVEIAAEL 153 Query: 220 SLNFLHALEVMFKST-------VQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQ 272 + + L + ++ V+ F R R P++ E A ++ Y I Sbjct: 154 PMQMICILLGVPETDRHWLFEAVEPGFDFRGSRRATMPRLNVED--AGSRLYTYALELIA 211 Query: 273 KIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELAR 332 E A + + LS + L + +TT + L LA Sbjct: 212 GKRAEPADDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAE 271 Query: 333 NPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVL 392 NPD Q LR ++ LL A++E +R R S + L Sbjct: 272 NPDQLQTLR------------------SDFELLPTAIEEIVRWTSPSPSKRRTASRAVSL 313 Query: 393 QNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLG 452 I AG V V+ S R+ ++F R + ++ R + H+ FG G+ CLG Sbjct: 314 GGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITR--------KPNPHLGFGQGVHYCLG 365 Query: 453 RRLAEAEMLLLLHHVLKHFLVETLTQ 478 LA E+ +L +L F + + Sbjct: 366 ANLARLELRVLFEELLSRFGSVRVVE 391 >5XW2-A nrPDB Length = 419 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 67/371 (18%), Positives = 127/371 (34%), Gaps = 39/371 (10%) Query: 120 RQHRGHKCGVFLLNGP-EWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQ 178 G+ + +L P + + RL P + L D + L+K V Sbjct: 55 WNVYGYAEAIEVLGDPGTFSSHMSRLLPMGADEAFTEGDLLQTDP---PDHRELRKLVSH 111 Query: 179 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM 238 + +++P I T E + + L+ + + L + + L Sbjct: 112 AFTPKVVAELEPRITALTQELLDAVADRDTFDLMTALAYPLPVTVVAELLSIPSADRHLF 171 Query: 239 F-MPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQ---ELAFNRPQHYTGIVAELL 294 + + ++ E + IF+ G ++K+ + E A + G + L Sbjct: 172 EGWMTEIVHSLGDVSMEDAPEDQERIFEAGMAPMRKMLEYLREHAAECRRRPRGDLMGKL 231 Query: 295 LKAELSLEAIKANSM-----ELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAA 349 ++AE+ + N + L TT + T+ L P+ +R + Sbjct: 232 IEAEVDGRRLTDNHIVNFAKMLLIAGYLTTTMLIGNTVLCLDSYPEQAARVRADR----- 286 Query: 350 SISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYS 409 L+ L+E++R R + D+ + + A +V V+ + Sbjct: 287 -------------SLIPGLLEESMRFLSPVAATYRATTRDVEVAGQRLSADQMVMVWFGA 333 Query: 410 LGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 R+A F PE ++ R + H+ FG G+ CLG LA E + L H+L Sbjct: 334 ANRDARQFAEPELFDMTRGPN--------PHLGFGRGIHFCLGGPLARMEGRVALDHLLD 385 Query: 470 HFLVETLTQED 480 F E Sbjct: 386 RFPELYTDPER 396 >6CVC-A nrPDB Length = 433 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 65/387 (16%), Positives = 134/387 (34%), Gaps = 39/387 (10%) Query: 119 YRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQ 178 + H F PE + + +P+ + F M+ + Q L+ V + Sbjct: 73 HWALTKHDDIHFASRHPEIFHSSPNIVIHDQTPELAEYFGSMI-VLDDPRHQRLRSIVSR 131 Query: 179 NARGSLTLDVQPSIFHYTIEASNLALFGE---RLGLVGHSPSSASLNFLHALEVMFKSTV 235 + ++ S+ + + LV L + + + + Sbjct: 132 AFTPKVVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPEEDH 191 Query: 236 QLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLL 295 + +F ++ F D Q I LA +R ++ G + L+ Sbjct: 192 EQIFHWTNVILGFGDPDLTTDF---DEFLQ-VSMAIGGYATALADDRRVNHHGDLTTSLV 247 Query: 296 KAELSLEAIKANSMELTA-----GSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAAS 350 +AE+ E + ++ + + +TT + + L+R PD Sbjct: 248 EAEVDGERLSSSEIAMFFILLVVAGNETTRNAISHGMLALSRYPD--------------- 292 Query: 351 ISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSL 410 E + + L A++E +R +++ R +S D+ L+ + AG V ++ S Sbjct: 293 --ERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLSQDVDLRGTKMAAGDKVTLWYCSA 350 Query: 411 GRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF-GFGMRQCLGRRLAEAEMLLLLHHVLK 469 R+ F P ++ R + + V F G G CLG LA E+ ++ + + Sbjct: 351 NRDEEKFADPWTFDVTRNPNPQ--------VGFGGGGAHFCLGANLARREIRVVFDELRR 402 Query: 470 HFLVETLTQEDIKMVYSFILRPGTSPL 496 T+E +++ FI P+ Sbjct: 403 QMPDVVATEEPARLLSQFIHGIKRLPV 429 >3R9C-A nrPDB Length = 418 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 56/331 (16%), Positives = 106/331 (32%), Gaps = 35/331 (10%) Query: 167 DFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHA 226 L+ V + + ++P I + + A+ G L+ + + + Sbjct: 103 PDHTRLRGLVSKAFAPRVIKRLEPEITALVDQLLD-AVDGPEFNLIDNLAYPLPVAVICR 161 Query: 227 LEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDN--CIQKIYQELAFNRPQ 284 L + +L E D + ++ + L R + Sbjct: 162 LLGVPIEDEPKFSRASALLAAALDPFLALTGETSDLFDEQMKAGMWLRDYLRALIDERRR 221 Query: 285 HYTGIVAELLL-----KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQI 339 + L+ +L+ + I A L +TT + + R P Sbjct: 222 TPGEDLMSGLVAVEESGDQLTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWAA 281 Query: 340 LRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPA 399 L + A+ A ++ET+R P + R DL + + +P Sbjct: 282 LAADGSRAS------------------AVIEETMRYDPPVQLVSRYAGDDLTIGTHTVPK 323 Query: 400 GTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAE 459 G + + L + R+ + P+R++P R H+ FG G CLG LA E Sbjct: 324 GDTMLLLLAAAHRDPTIVGAPDRFDPDR--------AQIRHLGFGKGAHFCLGAPLARLE 375 Query: 460 MLLLLHHVLKHFLVETLTQEDIKMVYSFILR 490 + L + F L+ E + + LR Sbjct: 376 ATVALPALAARFPEARLSGEP-EYKRNLTLR 405 >5DQN-A nrPDB Length = 426 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 53/347 (15%), Positives = 108/347 (31%), Gaps = 40/347 (11%) Query: 146 PDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALF 205 P ++ +AV ++ + L+K + + ++ + + + A Sbjct: 84 PQDMTREAVDLQRAVLLNMDAPQHTRLRKIISRGFTPRAIGRLEDELRSRAQKIAQTAAA 143 Query: 206 GERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQ 265 V L + L + + +F RW + E E D Sbjct: 144 QGAGDFVEQVSCELPLQAIAELLGVPQDDRDKLF------RWSNEMTAGEDPEYADVDPA 197 Query: 266 YGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKAN-----SMELTAGSVDTTA 320 + ++A R + T + L++A++ E + + + L +TT Sbjct: 198 MSSFELISYAMKMAEERAVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAVAGNETTR 257 Query: 321 FPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL 380 + + A+NPD ++ ++E A E +R Sbjct: 258 NSITHGMIAFAQNPDQWELYKKERP--------------------ETAADEIVRWATPVS 297 Query: 381 FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHH 440 +R D+ L I G V + S + +F P +N R + H Sbjct: 298 AFQRTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPN--------PH 349 Query: 441 VPFGF-GMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYS 486 V FG G C+G LA + L+ + + + ++ Sbjct: 350 VGFGGTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAPERLKSG 396 >5FOI-A nrPDB Length = 408 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 61/321 (19%), Positives = 117/321 (36%), Gaps = 41/321 (12%) Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL-FGERLGLVGHSPSSASLNFLHAL 227 L++ + ++P I + L + ++ H S + Sbjct: 107 HTRLRRMFISAFSVRQVETMRPEIEKIVDGILDRLLALEPPVDILTHLALPMSTQVI--- 163 Query: 228 EVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYT 287 L+ +P + + D ++ + + T Sbjct: 164 -------CHLLGVPYEDREFFQERSELASRPNDDRSMPALIELVEYLDGLVRTKTAHPDT 216 Query: 288 GIV----AELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE 343 G++ E LLK E++ + + N++ L A +T+A + +++ L R+P+ LR++ Sbjct: 217 GLLGTAVTERLLKGEITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELREQ 276 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLV 403 L+ A+ E LR + + L R ++D+VL ++ I AG + Sbjct: 277 PE------------------LMPNAVDELLRYHSIADGLRRAATADIVLGDHTIRAGDGL 318 Query: 404 QVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLL 463 + L S + F ++ R HHV FG+G QCLG+ LA EM + Sbjct: 319 IILLSSANHDGNTFGAEATFDIHR--------PARHHVAFGYGPHQCLGQNLARLEMEVT 370 Query: 464 LHHVLKHFLVETLTQEDIKMV 484 L + + L QE + Sbjct: 371 LGKLFRRVPALRLAQEPDALR 391 >3MGX-A nrPDB Length = 415 Score = 171 bits (433), Expect = 6e-43, Method: Composition-based stats. Identities = 65/426 (15%), Positives = 134/426 (31%), Gaps = 46/426 (10%) Query: 81 YNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKC--GVFLLNGPEWR 138 +LG P + + + + + H+ V + P Sbjct: 26 VDLGNPDLYTTLERHARWRELAAEDAMVWSDPGSSPSGFWSVFSHRACAAVLAPSAPLTS 85 Query: 139 FNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIE 198 + + D P + +V + + L+K V + + + + Sbjct: 86 EYGMMIGFDRDHPDNSGGRMMVVSE--HEQHRKLRKLVGPLLSRAAARKLAERVRIEVGD 143 Query: 199 ASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM-----FMPRSLSRWISPKVW 253 L GE + + + ++ Sbjct: 144 VLGRVLDGEVCDAATAIGPRIPAAVVCEILGVPAEDEDMLIDLTNHAFGGEDELFDGMTP 203 Query: 254 KEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTA 313 ++ I Y D I R + +V+ L+ +L+++ + N + Sbjct: 204 RQAHT---EILVYFDELITAR-------RKEPGDDLVSTLVTDDDLTIDDVLLNCDNVLI 253 Query: 314 GSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETL 373 G +TT + + LA P + LR S ++E L Sbjct: 254 GGNETTRHAITGAVHALATVPGLLTALRDGSADV------------------DTVVEEVL 295 Query: 374 RLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRG 433 R + + RV ++D+ + +P+GT V +L + R+ A F P+ + P R Sbjct: 296 RWTSPAMHVLRVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPDTFLPGR------ 349 Query: 434 SGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGT 493 + H+ FG GM CLG LA E+ ++L + + L +E + + +++ Sbjct: 350 --KPNRHITFGHGMHHCLGSALARIELSVVLRVLAERVSRVDLEREPA-WLRAIVVQGYR 406 Query: 494 SPLLTF 499 + F Sbjct: 407 ELPVRF 412 >2VZM-A nrPDB Length = 436 Score = 171 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 74/431 (17%), Positives = 140/431 (32%), Gaps = 50/431 (11%) Query: 81 YNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFN 140 +LG P + + R+ G+ +L P + + Sbjct: 35 LDLGALGQDFAADPYPTYARLRAEGP-AHRVRTPEGNEVWLVVGYDRARAVLADPRFSKD 93 Query: 141 -RLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYT--I 197 R P + A+ + D L+K V + ++P + + Sbjct: 94 WRNSTTPLTEAEAALNHNMLESDP---PRHTRLRKLVAREFTMRRVELLRPRVQEIVDGL 150 Query: 198 EASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHF 257 + LA R L+ + + L + + + ++ P + Sbjct: 151 VDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTD--AFVFPDDPAQAQ 208 Query: 258 EAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE-----LSLEAIKANSMELT 312 A + Y I R Q +++ L+ ++ L+ E + + L Sbjct: 209 TAMAEMSGYLSRLIDS-------KRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHILL 261 Query: 313 AGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKET 372 +TT + ++ L +PD LR + + LL A++E Sbjct: 262 VAGHETTVNLIANGMYALLSHPDQLAALRAD------------------MTLLDGAVEEM 303 Query: 373 LRLY-PVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDI 431 LR PV R + L IPAG V V L R FP P R++ +R Sbjct: 304 LRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRR---- 359 Query: 432 RGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVY--SFIL 489 H+ FG G+ C+G LA E + + +L+ L ++V+ + ++ Sbjct: 360 ----DTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPNPMI 415 Query: 490 RPGTSPLLTFR 500 R + + +R Sbjct: 416 RGLKALPIRWR 426 >4UBS-A nrPDB Length = 393 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 82/428 (19%), Positives = 143/428 (33%), Gaps = 80/428 (18%) Query: 77 PIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVA----YRQHRGHKCGVFLL 132 P+ R +L R V V+ + D L + A + R + + + Sbjct: 27 PLSRVSLYDGRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGV 86 Query: 133 NGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSI 192 + PE R R L P +A AL+ ++ + G Sbjct: 87 DDPEHRTQRRMLVPSFTLKRAA----------------ALRPRIQETVDGL--------- 121 Query: 193 FHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKV 252 L + A L AL + L+ +P + + + Sbjct: 122 ----------------LDAMEAQGPPAELVSAFALPLPSMVICALLGVPYADHDFFESQS 165 Query: 253 WKEHF-EAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAEL----LLKAELSLEAIKAN 307 + + +Y + R + G++ +L L + + + + Sbjct: 166 RRLLRGPGIAEVQDARAQLDDYLYALIDRKRKEPGDGLLDDLIQEQLNRGTVDRAELVSL 225 Query: 308 SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRA 367 + L +TTA + + F L R+P+ LR E L+ A Sbjct: 226 ATLLLIAGHETTANMISLGTFTLLRHPEQLAELRAEP------------------GLMPA 267 Query: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 A++E LR + L RV + D+ + I A V + R+AA F P+ + R Sbjct: 268 AVEELLRFLSIADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHR 327 Query: 428 WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSF 487 HHV FGFG+ QCLG+ LA AEM + L + + L ++ + Sbjct: 328 SA--------RHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADEIPF-- 377 Query: 488 ILRPGTSP 495 +PG + Sbjct: 378 --KPGDTI 383 >4GGV-A nrPDB Length = 418 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 62/373 (16%), Positives = 121/373 (32%), Gaps = 47/373 (12%) Query: 120 RQHRGHKCGVFLLNG-PEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQ 178 G+ + +LN + + L P + ++ + +D + ++ V + Sbjct: 56 WNVYGYPEAMDILNDHDTFTSDLAHLLPVSVDAPLLEGDMSQMDP---PRHRKYRQLVSR 112 Query: 179 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM 238 L D++ + T E + + + + + L + L Sbjct: 113 AFTPRLVADMETRVADITRELLDAVDGKPEIEIAADLAYPLPVIVIAELLGVPAGDRDLF 172 Query: 239 FM--------PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIV 290 S + ++ + + + E R + + Sbjct: 173 KKWADDIIEGFSGFSFLDTSGQGEQDVRDATERLRPLLDYMAGHVTE----RRRTPREDL 228 Query: 291 AELLLKAELSLEAIKANSME-----LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESL 345 L++AE+ E + N + L TT L T+ L +P+V +R + Sbjct: 229 LTHLVQAEVDGERLTDNEIVNVANILLVTGHITTTMTLGNTVLCLDADPEVAAKVRADR- 287 Query: 346 AAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQV 405 L+ A++E LR+ L R S ++ + IP +V + Sbjct: 288 -----------------SLVPGAIEEALRVLSPSAALARGTSREVEVAGTVIPKDQIVML 330 Query: 406 FLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLH 465 +L + R+ F PE Y+P R + H FG G+ CLG LA E + L+ Sbjct: 331 WLGAGNRDPRQFTDPEVYDPTRDPN--------PHFGFGRGIHFCLGAPLARLEGRVALN 382 Query: 466 HVLKHFLVETLTQ 478 + F V Sbjct: 383 ALFDRFPVLRTDP 395 >3A50-A nrPDB Length = 411 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 71/343 (20%), Positives = 128/343 (37%), Gaps = 61/343 (17%) Query: 159 PMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSS 218 PM+ + L+K V ++ +++P I GL+ P+ Sbjct: 85 PMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEIA------------DGLLAGLPTD 132 Query: 219 ASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQK----- 273 ++ + E F+ VQ++ L P ++ F AW + K Sbjct: 133 GPVDLMR--EYAFQIPVQVICELLGL-----PAEDRDDFSAWSSVLVDDSPADDKNAAMG 185 Query: 274 -----IYQELAFNRPQHYTGIVAELLLKAEL-----SLEAIKANSMELTAGSVDTTAFPL 323 + L R + +++ LL +++ S E + A +M L +TT + Sbjct: 186 KLHGYLSDLLERKRTEPDDALLSSLLAVSDMDGDRLSQEELVAMAMLLLIAGHETTVNLI 245 Query: 324 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRL-YPVGLFL 382 + L +PD +++L ++ L+ +A++E LR PV Sbjct: 246 GNGVLALLTHPDQRKLLAEDP------------------SLISSAVEEFLRFDSPVSQAP 287 Query: 383 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVP 442 R + D+ IPAG +V + L + R+A P P+R + R SG F Sbjct: 288 IRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITR----DASGGVF---- 339 Query: 443 FGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVY 485 FG G+ CLG +LA E + + + L ++VY Sbjct: 340 FGHGIHFCLGAQLARLEGRVAIGRLFADRPELALAVGLDELVY 382 >4YZR-A nrPDB Length = 405 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 57/340 (16%), Positives = 112/340 (32%), Gaps = 32/340 (9%) Query: 163 AVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLN 222 A L+ V Q +++ SI + + + ++ S Sbjct: 93 AKDTPDHTRLRSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFI 152 Query: 223 FLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNR 282 + L + K + + S + +A Y I + + Sbjct: 153 VISELMGIPKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLI---HDRRIKPK 209 Query: 283 PQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQ 342 + +V ++LS + + + L ++TT L L ++ + L+Q Sbjct: 210 DDLISKLVHAEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQ 269 Query: 343 ESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE-RVVSSDLVLQNYHIPAGT 401 + ++ A++E LR + + R D + + I G Sbjct: 270 QPE------------------MIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGD 311 Query: 402 LVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEML 461 ++ + + S R+ F PE N R + H+ FGFG+ CLG LA E Sbjct: 312 MIFIGIGSANRDPNFFENPEILNINRSPN--------RHISFGFGIHFCLGAPLARLEGH 363 Query: 462 LLLHHVLKHFLV--ETLTQEDIKMVYSFILRPGTSPLLTF 499 + +LK F + +DI+ + LR S ++ Sbjct: 364 IAFKALLKRFPDIELAVAPDDIQWRKNVFLRGLESLPVSL 403 >4PWV-A nrPDB Length = 446 Score = 169 bits (427), Expect = 4e-42, Method: Composition-based stats. Identities = 76/429 (17%), Positives = 141/429 (32%), Gaps = 45/429 (10%) Query: 77 PIFRYNLGGPRMVCVMLPEDVEKLQQVDSL---HPCRMILEPWVAYRQHRGHKCGVFLLN 133 I NL PR V + + + HP + ++ Sbjct: 34 DISTINLTDPRTYEVNDLSEYWRQLRTTRPLYWHPPVGDAPGFWVVSRYADVMALYKDNK 93 Query: 134 GPEWRFNRLRLNPDVLSPKAVQRFLPMVD-AVARDFSQALKKKVLQNARGSLTLDVQPSI 192 + + A + L + D A+ R L K A + ++ + Sbjct: 94 KLTSEKGNVLVTLLAGGDSAAGKMLAVTDGAMHRGLRNVLLKSFSPQALKPIVDQIRVNT 153 Query: 193 FHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKV 252 ++A+ LN + L + + + + + + S S Sbjct: 154 TRLVVDAARRG----ECDFAADVAEQIPLNTISDLLGVPAADREFL-LKLNKSALSSEDA 208 Query: 253 WKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKA-----ELSLEAIKAN 307 + +AW N I + EL R T V +L + L+ E I N Sbjct: 209 DQSATDAW-----LARNEILLYFSELVAERRAKPTEDVISVLANSMVDGKPLTEEVIVLN 263 Query: 308 SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRA 367 L G +T+ ++ ++ + PD ++LR + L + Sbjct: 264 CYSLILGGDETSRLSMIDSVQTFTQYPDQWELLRDGKVT------------------LES 305 Query: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 A +E LR + R +D+ L I AG +V ++ S R+ +F P ++ R Sbjct: 306 ATEEVLRWATPAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNR 365 Query: 428 WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSF 487 + H+ FG+G CLG L AE+ LL + + +T E ++ +F Sbjct: 366 SPNK--------HITFGYGPHFCLGAYLGRAEVHALLDALRTYTTGFEITGEPQRIHSNF 417 Query: 488 ILRPGTSPL 496 + P+ Sbjct: 418 LTGLSRLPV 426 >5XJN-A nrPDB Length = 455 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 55/339 (16%), Positives = 112/339 (33%), Gaps = 32/339 (9%) Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALE 228 ++ + ++P I I+ L ++ S + + + L Sbjct: 143 HTRIRAIAQKAFTPRRYKALEPDIRAMVIDRVEKMLANDQHVGDMVSDLAYDIPTITILT 202 Query: 229 VMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTG 288 ++ + + ++ + S + W + + + + Q + + H Sbjct: 203 LI-GADISMVDTYKRWSDSRAAMTWGDLSDEEQIPHAHNLVEYWQECQRMVADAHAHGGD 261 Query: 289 IVAELLLKA-----ELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE 343 + L++A E++ I + L +TT + L +P+ Q + Sbjct: 262 NLTADLVRAQQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAI--- 318 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLV 403 L+ AA+ E LR + R D + I G V Sbjct: 319 ---------------LENPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGV 363 Query: 404 QVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLL 463 + + S R+ A F E ++ R H+ FGFG+ CLG LA+ + + Sbjct: 364 LLLMGSANRDEARFENGEEFDISR-------ANAREHLSFGFGIHYCLGNMLAKLQAKIC 416 Query: 464 LHHVLKHFL-VETLTQEDIKMVYSFILRPGTSPLLTFRA 501 L V + + + + I + R TS +T+ A Sbjct: 417 LEEVTRLVPSLHLVADKAIGFRENLSFRVPTSVPVTWNA 455 >5GWE-A nrPDB Length = 405 Score = 168 bits (425), Expect = 6e-42, Method: Composition-based stats. Identities = 55/339 (16%), Positives = 112/339 (33%), Gaps = 32/339 (9%) Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALE 228 ++ + ++P I I+ L ++ S + + + L Sbjct: 93 HTRIRAIAQKAFTPRRYKALEPDIRAMVIDRVEKMLANDQHVGDMVSDLAYDIPTITILT 152 Query: 229 VMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTG 288 ++ + + ++ + S + W + + + + Q + + H Sbjct: 153 LI-GADISMVDTYKRWSDSRAAMTWGDLSDEEQIPHAHNLVEYWQECQRMVADAHAHGGD 211 Query: 289 IVAELLLKA-----ELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE 343 + L++A E++ I + L +TT + L +P+ Q + Sbjct: 212 NLTADLVRAQQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAI--- 268 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLV 403 L+ AA+ E LR + R D + I G V Sbjct: 269 ---------------LENPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGV 313 Query: 404 QVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLL 463 + + S R+ A F E ++ R H+ FGFG+ CLG LA+ + + Sbjct: 314 LLLMGSANRDEARFENGEEFDISR-------ANAREHLSFGFGIHYCLGNMLAKLQAKIC 366 Query: 464 LHHVLKHFL-VETLTQEDIKMVYSFILRPGTSPLLTFRA 501 L V + + + + I + R TS +T+ A Sbjct: 367 LEEVTRLVPSLHLVADKAIGFRENLSFRVPTSVPVTWNA 405 >2Y5N-A nrPDB Length = 417 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 70/420 (16%), Positives = 140/420 (33%), Gaps = 50/420 (11%) Query: 91 VMLPEDVEKLQQVDSLHPCRMILEPW-------VAYRQHRGHKCGVFLLNGPEWRFNRLR 143 V + ++ P + P+ Y R + GP + R Sbjct: 34 VHGLTLAGRYGELQETEPVSRVRPPYGEEAWLVTRYEDVRAVLGDGRFVRGPSMTRDEPR 93 Query: 144 LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASN-L 202 P+++ + P L++ V++ ++P E + + Sbjct: 94 TRPEMVKGGLLSMDPPE--------HSRLRRLVVKAFTARRAESLRPRAREIAHELVDQM 145 Query: 203 ALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDC 262 A G+ LV + + L + + + +E EA + Sbjct: 146 AATGQPADLVAMFARQLPVRVICELLGVPSADHDRFTRWSGAFLSTAEVTAEEMQEAAEQ 205 Query: 263 IFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFP 322 + Y + I + +E + +V + LS + + ++ L ++T Sbjct: 206 AYAYMGDLIDRRRKEP---TDDLVSALVQARDQQDSLSEQELLDLAIGLLVAGYESTTTQ 262 Query: 323 LLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYP--VGL 380 + ++ L P++++ L L+ +A++E R P VG Sbjct: 263 IADFVYLLMTRPELRRQL------------------LDRPELIPSAVEELTRWVPLGVGT 304 Query: 381 FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHH 440 R D+ L+ I AG V + R+ A FP +R + R + H Sbjct: 305 AFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDRTPN--------QH 356 Query: 441 VPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL--TQEDIKMVYSFILR-PGTSPLL 497 + FG G+ CLG LA E+ + L +L+ L + ++ +LR P P++ Sbjct: 357 LGFGHGVHHCLGAPLARVELQVALEVLLQRLPGIRLGIPETQLRWSEGMLLRGPLELPVV 416 >4OQS-A nrPDB Length = 433 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 55/295 (18%), Positives = 103/295 (34%), Gaps = 36/295 (12%) Query: 197 IEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWIS--PKVWK 254 +E + + + L + + L AL V +L+ + + + + Sbjct: 121 LEPRIVQITEDHLDAMAKAGPPVDLVQAFALPVPSLVICELLGVSYADHAFFQEQTTIMA 180 Query: 255 EHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAG 314 + D + + I + +A R ++ L+ +L+ E + ++ L Sbjct: 181 SVDKTQDEVTTALGKLTRYIAELVATKRLSPKDDLLGSLITDTDLTDEELTNIALLLLVA 240 Query: 315 SVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLR 374 +TTA L + F L ++P+ L A++E LR Sbjct: 241 GHETTANMLGLGTFALLQHPEQIAALDS-----------------------PDAVEELLR 277 Query: 375 LYPVGLFLE--RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIR 432 + R D+ L+ I G V + L ++ R+ +F P+ R Sbjct: 278 YLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR----- 332 Query: 433 GSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL--TQEDIKMVY 485 H FG G+ QCLG++LA EM + + F L E+IK+ Sbjct: 333 --VDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLRE 385 >6GK6-A nrPDB Length = 411 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 77/407 (18%), Positives = 134/407 (32%), Gaps = 60/407 (14%) Query: 110 RMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAV----- 164 R+ + WVA R + V LL P + +L +V +R+ P+ D Sbjct: 39 RLDVPIWVAVR----YDDCVELLKDPRLIRDFRKLPDEV-----RRRYFPLSDRTTFMDQ 89 Query: 165 -----ARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSA 219 L+ V + + ++P I + + R+ L+ Sbjct: 90 HMLDADPPDHTRLRAIVQRAFSPRMMEGLRPRIQEIADGLIDAVIDRRRMELIADFAFPL 149 Query: 220 SLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELA 279 + L + RW + + Q ++ LA Sbjct: 150 PTAVIAELLGLPVEDR------GRFRRWTKILLAPAKDREFVERAQPVVEEFAAYFRALA 203 Query: 280 FNRPQHYTGIVAELLLKAE-----LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNP 334 R + + LL AE LS + + L +TT + + L +P Sbjct: 204 DARRKAPRDDLISGLLLAEEQEHKLSPAELSSMVFLLLVAGHETTVHLIASGMLLLLSHP 263 Query: 335 DVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLY-PVGLFLERVVSSDLVLQ 393 ++ L ++ L+ +A++E LR P L R D+ L Sbjct: 264 AERRRLDEDP------------------GLVGSAVEEALRCEGPAELSTIRWSLEDIELF 305 Query: 394 NYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGR 453 +PAG V L + R+ FP P+R++ R + H+ FG G+ CLG Sbjct: 306 GARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGRSPN--------RHIGFGGGIHFCLGA 357 Query: 454 RLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYS---FILRPGTSPLL 497 LA E + +L+ L +V+S I P P++ Sbjct: 358 MLARIEAAIAFSTLLRRLPRIELATSTRDIVWSEWPTIRGPAAVPVV 404 >5CJE-A nrPDB Length = 393 Score = 166 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 75/426 (17%), Positives = 128/426 (30%), Gaps = 44/426 (10%) Query: 81 YNLGGPRMVCVMLPEDVEKLQQVDSL-HPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRF 139 +LG P V + H R GH+ L P Sbjct: 5 IDLGEYGARFTEDPYPVYAELRERGPVHWVRTPPPEAFEGWLVVGHEEARAALADPRLSK 64 Query: 140 NRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEA 199 + L+ V+ P + V L+ V + ++P I T Sbjct: 65 DG---TKKGLTSLDVELMGPYLLVVDPPEHTRLRSLVARAFTMRRVEALRPRIQEITDGL 121 Query: 200 SNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEA 259 + L R LV + + L + + ++P A Sbjct: 122 LDEMLPRGRADLVDSFAYPLPITVICELLGVPDIDRVTFRALSNEI--VAPTGGDAELAA 179 Query: 260 WDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLL-----KAELSLEAIKANSMELTAG 314 ++ + Y D I ++ +L+ LS E ++A + L Sbjct: 180 YERLAAYLDELID------DKRSTAPADDLLGDLIRTRAEDDDRLSGEELRAMAFILLVA 233 Query: 315 SVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLR 374 +TT + + L +PD LR + + LL A++E LR Sbjct: 234 GHETTVNLITNGVHTLLTHPDQLAALRAD------------------MTLLDGAVEEVLR 275 Query: 375 LY-PVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRG 433 PV R + + + I G V + L + GR+ A P P ++ R Sbjct: 276 FEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDPHVFDIHRAPQ--- 332 Query: 434 SGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGT 493 H+ FG G+ CLG LA E + L +L+ L ++R Sbjct: 333 -----GHLAFGHGIHYCLGAPLARLEARVALRSLLERCPDLALDGPPGARPPGMLIRGVR 387 Query: 494 SPLLTF 499 + + Sbjct: 388 RLPVRW 393 >3TYW-A nrPDB Length = 417 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 56/297 (18%), Positives = 106/297 (35%), Gaps = 33/297 (11%) Query: 195 YTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVW- 253 + + A E L + + L +A V +L+ +PR + Sbjct: 124 RAMRPAVQARVDEILDGMLAAGGPVDLVSAYANAVSTSVICELLGIPRHDLEFFRDVTRI 183 Query: 254 -----KEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANS 308 + + + + + R + +V + L+ ++ E + + Sbjct: 184 SGSRNSTAEQVSEALGGLFGLLGGLVAERREEPRDDLISKLVTDHLVPGNVTTEQLLSTL 243 Query: 309 MELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAA 368 +TT + ++ L P++ LR++ L+ AA Sbjct: 244 GITINAGRETTTSMIALSTLLLLDRPELPAELRKDPD------------------LMPAA 285 Query: 369 LKETLRLYPVGLFLE-RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 + E LR+ V + RV + D+ L +PA V L + F PER + R Sbjct: 286 VDELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHR 345 Query: 428 WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMV 484 + HHV FG+G+ QC+G+ LA E+ + L +L+ L E ++V Sbjct: 346 TDN--------HHVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERDQVV 394 >3WVS-A nrPDB Length = 401 Score = 164 bits (415), Expect = 8e-41, Method: Composition-based stats. Identities = 66/405 (16%), Positives = 132/405 (32%), Gaps = 43/405 (10%) Query: 96 DVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQ 155 D + L +V + W+A R ++ +L + + + K Sbjct: 34 DTDGLIRVKLPYGE----PAWLATR----YEDARLVLGDARFSRALSEEHDPPRARKFNA 85 Query: 156 RFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASN-LALFGERLGLVGH 214 + M + + L++ + + +++P + + + GE LV Sbjct: 86 QAKSMFN-MDAPDHTRLRRLISKAFTIRRVEELRPKVHDLAHRLIDDMLAKGEPADLVAD 144 Query: 215 SPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKI 274 + L + + S +E + Y I Sbjct: 145 YALPIPTTVICELLGVPFEDREKFGRWTDAILSTSTLNPEEGRVKRMELVGYIGGIIAAR 204 Query: 275 YQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNP 334 + A +G++ ++ +L+ + + + + L +TTA + ++ L P Sbjct: 205 RAQPAD---DLISGMIEARDVQDKLTEQELLDHCIGLLIAGHETTASQIPSFVYALLDQP 261 Query: 335 DVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYP--VGLFLERVVSSDLVL 392 + L + L+ +A++E R P G R D+ + Sbjct: 262 QHWKRLLDDPE------------------LIPSAVEELFRFVPLGSGSAAPRYAREDIEV 303 Query: 393 QNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLG 452 + AG V V L + R+ F PE R + HH+ FG G+ CLG Sbjct: 304 GGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDR--------PSNHHIGFGHGIHHCLG 355 Query: 453 RRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILR-PGTSPL 496 LA E+ L +L+ + DI ++R P + P+ Sbjct: 356 APLARLELQEALRALLERLPTLKVAG-DIAWKSEMMVRGPRSMPV 399 >4OQR-A nrPDB Length = 457 Score = 164 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 55/295 (18%), Positives = 103/295 (34%), Gaps = 36/295 (12%) Query: 197 IEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWIS--PKVWK 254 +E + + + L + + L AL V +L+ + + + + Sbjct: 160 LEPRIVRITEDHLDAMAKAGPPVDLVQAFALPVPSLVICELLGVSYADHAFFQEQTTIMV 219 Query: 255 EHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAG 314 + D + + I + +A R ++ L+ +L+ E + ++ L Sbjct: 220 SVDKTQDEVTTALGKLTRYIAELVATKRLSPKDDLLGSLITDTDLTDEELTNIALILLVA 279 Query: 315 SVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLR 374 +TTA L + F L ++P+ L A++E LR Sbjct: 280 GHETTANMLGLGTFALLQHPEQIANLDS-----------------------PDAVEELLR 316 Query: 375 LYPVGLFLE--RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIR 432 + R D+ L+ I G V + L ++ R+ +F P+ R Sbjct: 317 YLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR----- 371 Query: 433 GSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL--TQEDIKMVY 485 H FG G+ QCLG++LA EM + + F L E+IK+ Sbjct: 372 --VDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLRE 424 >4Z5P-A nrPDB Length = 400 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 62/375 (16%), Positives = 127/375 (33%), Gaps = 50/375 (13%) Query: 138 RFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTI 197 RF+R ++ D + R + ++ L++ + + +Q + Sbjct: 63 RFSRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSKAFTARRMGAMQSWLEELFA 122 Query: 198 EASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS----LSRWISPKVW 253 + ER G + F A+ +L+ +P W + Sbjct: 123 GLLDGV---ERTGHPADIVRDLAQPFTIAV------ICRLLGVPYEDRGRFQHWSEVIMS 173 Query: 254 KEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE-----LSLEAIKANS 308 + + + D I+ +L R + +L+ A L+ + + Sbjct: 174 TTAYSKEEAV--SADASIRAYLADLVSARRAAPHDDLLGVLVSARDDDDRLTEDELITFG 231 Query: 309 MELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAA 368 + L +T+A L ++ L + D +LR++ LL A Sbjct: 232 VTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPE------------------LLPRA 273 Query: 369 LKETLRLYPVGLFLE--RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQ 426 ++E LR P+G + R+ D+ L + AG V + R+ F P+R + Sbjct: 274 VEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDIT 333 Query: 427 RWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFL--VETLTQEDIKMV 484 R H+ FG G CLG +LA E+ + + +L+ F + + ++ Sbjct: 334 R--------EKNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQVEWK 385 Query: 485 YSFILRPGTSPLLTF 499 + R + + Sbjct: 386 TGGLFRGPQRLPIAW 400 >5Y1I-A nrPDB Length = 403 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 55/353 (15%), Positives = 119/353 (33%), Gaps = 39/353 (11%) Query: 140 NRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYT--- 196 R L+ +S ++ P + A + S A Q+ + ++ Sbjct: 53 QRALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPEHGRIRRMVTLPFTARRI 112 Query: 197 --IEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWK 254 + + + E + + P L AL V + +++ +P ++ Sbjct: 113 EAMRPAIQKITDELIDGMLAGPKPVDLVEALALPVPVRVICEMLGVPYEDREFLQQNNNA 172 Query: 255 EHFEAWDCIFQYGDNC-------IQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKAN 307 + D ++++ +R +A + E++ + Sbjct: 173 MIYR--DTAQGDAQKAAIAQAMYLKELVGTKLGDRGDDILSDLAVQVEAGEITQDDAAGI 230 Query: 308 SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRA 367 M L +TTA + + L NP+ +R + + ++ Sbjct: 231 GMMLLGAGHETTANMIALGTLALLENPEQLAEVR----------------DSDDPKVIVN 274 Query: 368 ALKETLRLYPVGL-FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPR-PERYNP 425 ++E LR + + R+ + D+ + I AG + L + + L+P P+R + Sbjct: 275 TVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDI 334 Query: 426 QRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQ 478 R H+ FG+G+ QCLG LA E+ ++ +L+ L Sbjct: 335 HR-------ANARRHLAFGYGVHQCLGATLARVELQIVYSTLLRRIPTLALAG 380 >5Z9I-A nrPDB Length = 398 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 69/392 (17%), Positives = 134/392 (34%), Gaps = 43/392 (10%) Query: 120 RQHRGHKCGVFLLNGPE-WRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQ 178 G+ +L+ P+ + + +RL+P L V+ D + L+ V Sbjct: 36 WNVYGYPESAAILSNPKVFSSDTMRLDPIKLDEAIVEGDFAHTDP---PKHRRLRGLVDH 92 Query: 179 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM 238 SL ++ + E + + LV + L + L + +S L Sbjct: 93 AFTPSLVAKMESRVHGIIHELLDGVEGKSQFDLVAEFAAPLPLIMISDLLGVPESDRALF 152 Query: 239 -----FMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAEL 293 M ++ SP+ E E ++ + E A + + Sbjct: 153 RQWMDKMLDGSEKFESPETVLEQEEEL-HKELELLWEMRDYWHERAAESRKRPREDLISQ 211 Query: 294 LLKAELSLEAIKANSME-----LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAA 348 L+ AE+ + + + + L TTA + T+ L D +R + Sbjct: 212 LVHAEVDGQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCLDAFSDQDARVRADR---- 267 Query: 349 ASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLY 408 L+ A L+E++R + R +S++ + IP L+ V+ Sbjct: 268 --------------SLVPALLEESMRYMSPICGVGRATNSEVEVAGTVIPKDQLLLVWTG 313 Query: 409 SLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468 + R+ F +P+ ++ R + H+ FG G+ CLGR+LA E + +L Sbjct: 314 AANRDERQFEKPDVFDAGRSPN--------AHLGFGRGIHFCLGRQLARMESKAAVEILL 365 Query: 469 KHFLVETLTQEDIKMVYSFILRPG--TSPLLT 498 + + G T P++T Sbjct: 366 DRLPTLRADPANPPTFLQVVDASGVATLPVVT 397 >6G5O-A nrPDB Length = 399 Score = 163 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 56/254 (22%), Positives = 102/254 (40%), Gaps = 37/254 (14%) Query: 225 HALEVMFKSTVQLMFMPRSLSR-WIS--PKVWKEHFEAWD-----CIFQYGDNCIQKIYQ 276 AL + ++ L+ P S S WIS V++ EA D ++ Y D I + + Sbjct: 126 FALRLQSRALTLLLNTPFSESETWISWGTHVFRSEGEALDGDKANILYHYIDEQIDRASE 185 Query: 277 ELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDV 336 + Y+ ++ +L+ E +K + AG DT + ++ LA +P+ Sbjct: 186 NPGDDM---YSVLLNSEFEGRKLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEA 242 Query: 337 QQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYH 396 + LR+E + A++E +R + + RVV+ D + + Sbjct: 243 LERLRKEPE------------------ITGRAVEEMIRYFSPLTQMGRVVTEDTHVCEHA 284 Query: 397 IPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLA 456 + A + + + S R+AA+F P R ++ HV FGF CLG A Sbjct: 285 VKADSRISLCWASANRDAAVFENPNEIVLDRKVN--------PHVGFGFSHHNCLGATHA 336 Query: 457 EAEMLLLLHHVLKH 470 + +LL + + Sbjct: 337 RQILKILLQTLAQK 350 >4YT3-A nrPDB Length = 410 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 60/345 (17%), Positives = 110/345 (31%), Gaps = 32/345 (9%) Query: 139 FNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIE 198 R ++ S + + + + + + +P I E Sbjct: 66 RKRTTISVGTDSEEGSVPEKIQITESDPPDHRKRRSLLAAAFTPRSLQNWEPRIQEIADE 125 Query: 199 ASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFE 258 G + +V S + + L + L + +E + Sbjct: 126 LIGQMDGGTEIDIVASLASPLPIIVMADLMGVPSKDRLLFKKWVDTLFLPFDREKQEEVD 185 Query: 259 AWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELL---LKAEL-SLEAIKANSMELTAG 314 + Q +Y + R I+++LL + E+ + + + +M + Sbjct: 186 KLKQVA--AKEYYQYLYPIVVQKRLNPADDIISDLLKSEVDGEMFTDDEVVRTTMLILGA 243 Query: 315 SVDTTAFPLLMTLFELA-RNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETL 373 V+TT+ L + + L + +V Q L + L L+ A++E L Sbjct: 244 GVETTSHLLANSFYSLLYDDKEVYQELHE------------------NLDLVPQAVEEML 285 Query: 374 RLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRG 433 R + L+R V D L + G V V++ + + +F P N R Sbjct: 286 RFRFNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHR------ 339 Query: 434 SGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQ 478 N H+ FG G CLG LA E + L LK F Sbjct: 340 -PNNKKHLTFGNGPHFCLGAPLARLEAKIALTAFLKKFKHIEAVP 383 >4WPZ-A nrPDB Length = 397 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 70/350 (20%), Positives = 130/350 (37%), Gaps = 51/350 (14%) Query: 164 VARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNF 223 + L+K V + ++P I L G+ L + P L Sbjct: 85 MDAPEHTRLRKLVTKAFTARRVETLRPRITE---------LVGQLLDELETLPRPVDLVK 135 Query: 224 LHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEA-WDCIFQYGDNCIQ--KIYQEL-A 279 ++ + + +L+ +P W W + + + + EL A Sbjct: 136 NFSVPLPVRVICELLGVPAGDQDTF--HAWSNALLGDWQQVVEKEAATVSLVNYFGELIA 193 Query: 280 FNRPQHYTGIVAELLLKAE----LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPD 335 R +++EL+ ++ L+ I A S+ + + +TTA + M L L NP+ Sbjct: 194 VKRENPADDLISELIAISDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNPE 253 Query: 336 VQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYP---VGLFLERVVSSDLVL 392 LR A + A+ E LR P G + R+ ++++ L Sbjct: 254 ELDKLRDNREA------------------IPKAVDELLRFVPLTTTGGIIPRLTTAEVEL 295 Query: 393 -QNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCL 451 +PAG +V + + R+ +F ER N R N H+ FG G+ CL Sbjct: 296 SGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTR--------ENNPHLAFGAGIHHCL 347 Query: 452 GRRLAEAEMLLLLHHVLKHFL--VETLTQEDIKMVYSFILRPGTSPLLTF 499 G +LA E+ L +L + + ++++ + I+R S +T+ Sbjct: 348 GAQLARIELQEALGAILDRMPQVRLAVPESELRLKSASIIRGLESLPITW 397 >5EX6-C nrPDB Length = 434 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 56/291 (19%), Positives = 101/291 (34%), Gaps = 31/291 (10%) Query: 195 YTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWK 254 + + ERL + S A L L A EV +L+ +PR + Sbjct: 149 RRMAPYIEQIVTERLDEMEREGSPADLIELFADEVPGPVLCELLGVPRDDRAMFLQLCHR 208 Query: 255 --EHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLK--AELSLEAIKANSME 310 + + G+ + + +A R G++ ++ + ++ E ++ ++ Sbjct: 209 HLDASLSGRRRAAAGEAFSRYLVTMVARERKDPGDGLIGMVVAEHGDTVTDEELRGVCVQ 268 Query: 311 LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALK 370 + D + + + + L RNP+ LR ++P A+ Sbjct: 269 MMLAGDDNISGMIGLGVLALLRNPEQIAALR------------------GDVPAAERAVD 310 Query: 371 ETLRLYP-VGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWL 429 E +R R D + + I AG V L + R+ AL P +R + R Sbjct: 311 ELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTR-- 368 Query: 430 DIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED 480 HV FG G+ CLG LA E+ + + + F L D Sbjct: 369 ------EAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADPD 413 >2Z36-A nrPDB Length = 413 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 55/338 (16%), Positives = 119/338 (35%), Gaps = 34/338 (10%) Query: 143 RLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTI-EASN 201 D + + ++ P++ + A ++ V+ ++P I + Sbjct: 77 LFTLDAATLQQLRSQPPLMLGMDGAEHSAARRPVIGEFTVKRLAALRPRIQDIVDHFIDD 136 Query: 202 LALFGER-LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAW 260 + +R + LV + L + + F + +S ++ A+ Sbjct: 137 MLATDQRPVDLVQALSLPVPSLVICELLGVPYTDHD--FFQSRTTMMVSRTSMEDRRRAF 194 Query: 261 DCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTA 320 + Y D+ I + E ++ +A + L + + + L +TTA Sbjct: 195 AELRAYIDDLITRKESEPGD---DLFSRQIARQRQEGTLDHAGLVSLAFLLLTAGHETTA 251 Query: 321 FPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL 380 + + + L +P+ +++ A++E LR + + Sbjct: 252 NMISLGVVGLLSHPEQLTVVKANPGR------------------TPMAVEELLRYFTIAD 293 Query: 381 FLE-RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFH 439 + R+ + D+ + I AG V V + S + A+F P + +R H Sbjct: 294 GVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVERGA--------RH 345 Query: 440 HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLT 477 H+ FGFG QCLG+ LA E+ ++ + + L Sbjct: 346 HLAFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLA 383 >3ABB-A nrPDB Length = 408 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 55/290 (18%), Positives = 104/290 (35%), Gaps = 37/290 (12%) Query: 196 TIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWI------- 248 I +L L + A L AL V + +L+ +P + Sbjct: 120 AIRPRLQSLVDRLLDDMLAKGPGADLVSAFALPVPSVAICELLGVPYGDHDFFEECSRNF 179 Query: 249 -SPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKAN 307 E A+ ++ Y + + E ++A L + +L + + Sbjct: 180 VGAATSAEADAAFGELYTYLHGLVGRKQAEPEDG---LLDELIARQLEEGDLDHDEVVMI 236 Query: 308 SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRA 367 ++ L +TT + + L ++P+ +L ++ A + Sbjct: 237 ALVLLVAGHETTVNAIALGALTLIQHPEQIDVLLRDPGAVSG------------------ 278 Query: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 ++E LR V + R+ D+ + I AG V V + + R+A + P+ ++ +R Sbjct: 279 VVEELLRFTSVSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARR 338 Query: 428 WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLT 477 HHV FG G+ QCLG+ LA AE+ + L + L Sbjct: 339 --------NARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLA 380 >3TKT-A nrPDB Length = 450 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 63/352 (17%), Positives = 121/352 (34%), Gaps = 38/352 (10%) Query: 157 FLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL-FGERLGLVGHS 215 + + + L++ + I EA + L GE + Sbjct: 120 LVESLVQMDAPKHPKLRRLTQDWFMPKNLARLDGEIRKIANEAIDRMLGAGEEGDFMALV 179 Query: 216 PSSASLNFLHALEVMFKSTV-QLMFMPRSLSRWISPKVWKEHF-----EAWDCIFQYGDN 269 + L+ + + + +++F+ + + + K E I Sbjct: 180 AAPYPLHVVMQILGVPPEDEPKMLFLTQQMFGGQDEDMNKSGLKDLPPEQISQIVAGAVA 239 Query: 270 CIQKIYQELAFNRPQHYTGIVAELLLKAELSLE-----AIKANSMELTAGSVDTTAFPLL 324 ++ + LA R ++ T VA ++ A + E + + DTT+ Sbjct: 240 EFERYFAGLAAERRRNPTDDVATVIANAVVDGEPMSDRDTAGYYIITASAGHDTTSASSA 299 Query: 325 MTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLER 384 LAR+PD+ ++ + LL ++E +R R Sbjct: 300 GAALALARDPDLFARVKADRN------------------LLPGIVEEAIRWTTPVQHFMR 341 Query: 385 VVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFG 444 ++D L I AG + + + + A FP P +++P R + H+ FG Sbjct: 342 TAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTRPAN--------RHLAFG 393 Query: 445 FGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPL 496 G QCLG LA EM +LL +L L E ++ +F+ + P+ Sbjct: 394 AGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVGGFKSLPM 445 >5XNT-A nrPDB Length = 411 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 68/359 (18%), Positives = 127/359 (35%), Gaps = 66/359 (18%) Query: 126 KCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLT 185 K + + PE R R L +P+++Q + P + +A + + + ++ Sbjct: 85 KIKITEADPPEHRKRRSLLAA-AFTPRSLQNWEPRIQEIADELIEEMDEETE-------- 135 Query: 186 LDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLS 245 +D+ S+ + + + +G+ ++FK V ++F+P Sbjct: 136 IDIVQSL----ASPLPIIVMSDLMGVPSKD------------RLLFKKWVDILFLPFD-- 177 Query: 246 RWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE-----LS 300 KE E + + Q + + + + + LLKAE + Sbjct: 178 --------KEKQEEVNELKQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKAEVDGEMFT 229 Query: 301 LEAIKANSMELTAGSVDTTAFPLLMTLFELA-RNPDVQQILRQESLAAAASISEHPQKAT 359 + + +M + V+TT+ L + + L + +V Q L + Sbjct: 230 DDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHE----------------- 272 Query: 360 TELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPR 419 L L+ A++E LR + L+R V D L + G V V++ + + +F Sbjct: 273 -NLDLVPQAVEEMLRYRFNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFED 331 Query: 420 PERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQ 478 N R N H+ FG G CLG LA E + L LK F Sbjct: 332 AFTLNIHR-------PNNKKHLTFGNGPHFCLGAPLARLEAKIALTTFLKKFKHIEAVP 383 >2RFC-A nrPDB Length = 343 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 58/333 (17%), Positives = 109/333 (32%), Gaps = 49/333 (14%) Query: 156 RFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHS 215 F+ M + ++F S D + I + + + ++ Sbjct: 46 SFITMDNPEHKEFRDI----SAPYFLPSKINDYKDFIEETSNDLIKNI---DNKDIISEY 98 Query: 216 PSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDN-CIQKI 274 +N + + + S + L + D F Y +N + ++ Sbjct: 99 AVRLPVNIISKILGIPDSDMPLFKLWSDYI----------IGNKRDENFNYVNNRMVSRL 148 Query: 275 YQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNP 334 + + + L +L+++ M L G +TT + + + NP Sbjct: 149 LEIFKSDSHGIINVLAGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENP 208 Query: 335 DVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE-RVVSSDLVLQ 393 D+ L ++ETLR Y FL R + D + Sbjct: 209 DI---------------------IDDALKNRSGFVEETLRYYSPIQFLPHRFAAEDSYIN 247 Query: 394 NYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGR 453 N I G V V+L S R+ F P+ + R H+ FG G+ CLG Sbjct: 248 NKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGR---------REMHLAFGIGIHMCLGA 298 Query: 454 RLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYS 486 LA E + L+ +L HF + + +++ + Sbjct: 299 PLARLEASIALNDILNHFKRIKIDYKKSRLLDN 331 >3ABA-A nrPDB Length = 403 Score = 158 bits (400), Expect = 4e-39, Method: Composition-based stats. Identities = 69/404 (17%), Positives = 133/404 (32%), Gaps = 67/404 (16%) Query: 91 VMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKC--GVFLLNGPEWRFNRLRLNPDV 148 V E+V L + DS ++ + + PE +R L + Sbjct: 48 VTGYEEVRALLR-DSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHTSDRKLLAKEF 106 Query: 149 LSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGER 208 + +Q P + + + A++ + +D+ + + LFG Sbjct: 107 TVRR-MQALRPNIQRIVDEHLDAIEAR-------GGPVDLVKTFANAVPSMVISDLFG-- 156 Query: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGD 268 P F E M +V ++ + G Sbjct: 157 ------VPVERRAEFQDIAEAMM-------------------RVDQDAAATEAAGMRLGG 191 Query: 269 NCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLF 328 Q + + A + ++ + + + L + DTTA + + Sbjct: 192 LLYQLVQERRANPGDDLISALITTEDPDGVVDDMFLMNAAGTLLIAAHDTTACMIGLGTA 251 Query: 329 ELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL-ERVVS 387 L +PD +LR++ L+ A++E LR +G F ERV + Sbjct: 252 LLLDSPDQLALLREDP------------------SLVGNAVEELLRYLTIGQFGGERVAT 293 Query: 388 SDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGM 447 D+ L I G V + + + A PER++ R R H+ FGFG Sbjct: 294 RDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITR--------RPAPHLAFGFGA 345 Query: 448 RQCLGRRLAEAEMLLLLHHVLKHFLVETL--TQEDIKMVYSFIL 489 QC+G++LA E+ ++ + + L E+++ + + Sbjct: 346 HQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFRHDMVF 389 >5IT1-A nrPDB Length = 399 Score = 158 bits (400), Expect = 4e-39, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 101/298 (33%), Gaps = 33/298 (11%) Query: 195 YTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISP---- 250 + + + E L + L A V L +P Sbjct: 112 QALRPNIQRIVDEHLDAIEARGGPVDLVKTFANPVPSMVISDLFGVPAERRAEFQEIAEA 171 Query: 251 --KVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANS 308 +V ++ + G Q + + A + ++ + + + Sbjct: 172 MMRVDQDAAATEAAGMRLGGLLYQLVQERRANPGDDLISALITTEDPDGVIDDMFLMNAA 231 Query: 309 MELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAA 368 L + DTTA + + L PD +L+++ L+ A Sbjct: 232 GTLLIAAHDTTACMIGLGTALLLDRPDQLALLQKDP------------------SLIGNA 273 Query: 369 LKETLRLYPVGLF-LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 ++E LR +G F ERV + D + I G V L S + A PER++ R Sbjct: 274 VEELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITR 333 Query: 428 WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVY 485 R H+ FGFG QC+G++LA E+ ++ + + F L + ++ + Sbjct: 334 --------RPAPHLAFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKPVEELRF 383 >6FSH-A nrPDB Length = 398 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 51/296 (17%), Positives = 101/296 (34%), Gaps = 31/296 (10%) Query: 195 YTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISP--KV 252 + + +RL + + A L L A EV +L+ +PR Sbjct: 113 RRLAPRIEEIVTDRLDAMEQAGPPADLIELFADEVPGAVLCELIGVPRDDRDMFMKLCHG 172 Query: 253 WKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLK--AELSLEAIKANSME 310 + + GD + + +A R G + ++ + ++ E ++ ++ Sbjct: 173 HLDASLSQKRRAALGDKFSRYLLAMIARERKDPGDGFIGSIVAEHGDTITDEELRGVCVQ 232 Query: 311 LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALK 370 L D + + + + L R+P+ LR + +A A+ Sbjct: 233 LMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSA------------------DRAVD 274 Query: 371 ETLRLYP-VGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWL 429 E +R R D+++ + I G V L R+ AL P +R + R Sbjct: 275 ELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR-- 332 Query: 430 DIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVY 485 HV FG G+ CLG L ++ + + + F L ++++ Sbjct: 333 ------TPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMF 382 >1Z8P-A nrPDB Length = 404 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 55/329 (16%), Positives = 119/329 (36%), Gaps = 40/329 (12%) Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALE 228 L+K V Q ++P + T E + + +V + + L Sbjct: 98 HTRLRKLVSQEFTVRRVEAMRPRVEQITAELLDEVGDSGVVDIVDRFAHPLPIKVICELL 157 Query: 229 VMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTG 288 + + S + P+ ++ +A + + + +++ R + Sbjct: 158 GVDEKYRGEFGRWSSEILVMDPERAEQRGQAAREVVNFILDLVERR-------RTEPGDD 210 Query: 289 IVAELLL-----KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE 343 +++ L+ LS + + + ++ L +++ + + + L +PD ++R++ Sbjct: 211 LLSALIRVQDDDDGRLSADELTSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVRRD 270 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLV 403 A L A++E LR R + ++ + IP + V Sbjct: 271 PSA------------------LPNAVEEILRYIAPPETTTRFAAEEVEIGGVAIPQYSTV 312 Query: 404 QVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLL 463 V + R+ FP P R++ R H+ FG G+ C+GR LA+ E + Sbjct: 313 LVANGAANRDPKQFPDPHRFDVTR--------DTRGHLSFGQGIHFCMGRPLAKLEGEVA 364 Query: 464 LHHVLKHFLVETL--TQEDIKMVYSFILR 490 L + F +L +D+ S +LR Sbjct: 365 LRALFGRFPALSLGIDADDVVWRRSLLLR 393 >4TX3-A nrPDB Length = 404 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 50/296 (16%), Positives = 102/296 (34%), Gaps = 31/296 (10%) Query: 195 YTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWK 254 + + +RL + + A L L A EV +L+ +PR + Sbjct: 119 RRLAPRIEEIVTDRLDAMEQAGPPADLIELFADEVPGAVLCELIGVPRDDQAMFLQLCHR 178 Query: 255 --EHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLK--AELSLEAIKANSME 310 + + G+ + + +A R G + ++ + ++ E ++ ++ Sbjct: 179 HLDASLSARKRAAAGEAFARYLVAMMARERKDPGDGFIGSIVAEHGDTITDEELRGVCVQ 238 Query: 311 LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALK 370 L D + + + + L R+P+ LR + +A A+ Sbjct: 239 LMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSA------------------DRAVD 280 Query: 371 ETLRLYP-VGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWL 429 E +R R D+++ + I G V L R+ AL P +R + R Sbjct: 281 ELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR-- 338 Query: 430 DIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVY 485 HV FG G+ CLG L ++ + + + F L ++++ Sbjct: 339 ------TPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMF 388 >3NC3-A nrPDB Length = 441 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 70/491 (14%), Positives = 152/491 (30%), Gaps = 83/491 (16%) Query: 17 SLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTF-QEL 75 S+ + +G + +++ F + N RE+ H + F Sbjct: 23 SMTGGQQMGRGSEFMSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFISRY 82 Query: 76 GPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGP 135 + + P+ V+ P ++ P +A + H Sbjct: 83 HDV---------RYILQHPDIFTTKSLVERAEP--VMRGPVLAQMHGKEHSA-------- 123 Query: 136 EWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHY 195 R+ + + A+ P++ A + ++ + + Sbjct: 124 ---KRRIVVRSFI--GDALDHLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCV--- 175 Query: 196 TIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKE 255 ++ +R S +F+ ++ ++ ++ LS+++ P + Sbjct: 176 ---TMDMLGLDKRDHEKISEWHSGVADFITSISQSPEARAHSLWCSEQLSQYLMPVI--- 229 Query: 256 HFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE-----LSLEAIKANSME 310 R + + +L +E LS + I A + Sbjct: 230 ------------------------KERRVNPGSDLISILCTSEYEGMALSDKDILALILN 265 Query: 311 LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALK 370 + + + L + ++ L NP+ + L+ A+ Sbjct: 266 VLLAATEPADKTLALMIYHLLNNPEQMN------------------DVLADRSLVPRAIA 307 Query: 371 ETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLD 430 ETLR P + R +S D V+ I T+V + + R+ F +P+ +N R Sbjct: 308 ETLRYKPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDL 367 Query: 431 IRGSGRN--FHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFI 488 S + H+ FG G+ C+G A+ E+ ++ + VL L ++ Sbjct: 368 GIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLY 427 Query: 489 LRPGTSPLLTF 499 R S L+ F Sbjct: 428 TRGPVSLLVAF 438 >1LG9-A nrPDB Length = 398 Score = 155 bits (391), Expect = 5e-38, Method: Composition-based stats. Identities = 59/363 (16%), Positives = 114/363 (31%), Gaps = 43/363 (11%) Query: 131 LLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQP 190 W + P+ + L D L++K+ + P Sbjct: 61 FSTRRRWDPRDEIGGKGIFRPRELVGNLMDYDP---PEHTRLRRKLTPGFTLRKMQRMAP 117 Query: 191 SIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISP 250 I + +RL + + S A L A +V +L+ +PR Sbjct: 118 YIEQ---------IVNDRLDEMERAGSPADLIAFVADKVPGAVLCELVGVPRDDRDMFMK 168 Query: 251 --KVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLK--AELSLEAIKA 306 + + GD + + +A R + G++ ++ + + + E ++ Sbjct: 169 LCHGHLDASLSQKRRAALGDKFSRYLLAMIARERKEPGEGMIGAVVAEYGDDATDEELRG 228 Query: 307 NSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLR 366 +++ D + + + + + R+P+ R + +A Sbjct: 229 FCVQVMLAGDDNISGMIGLGVLAMLRHPEQIDAFRGDEQSAQR----------------- 271 Query: 367 AALKETLRLYP-VGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNP 425 A+ E +R R+ DL L I G V L + R+ AL P +R + Sbjct: 272 -AVDELIRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDV 330 Query: 426 QRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVY 485 R HV FG G+ CLG LA E+ + + + F L + Sbjct: 331 TR--------EPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQDTEF 382 Query: 486 SFI 488 Sbjct: 383 RLT 385 >2FR7-A nrPDB Length = 412 Score = 154 bits (389), Expect = 8e-38, Method: Composition-based stats. Identities = 64/393 (16%), Positives = 126/393 (32%), Gaps = 33/393 (8%) Query: 111 MILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQ 170 + L+ W Y R + +LN P + + + R ++ Sbjct: 50 VYLDKWNVYGVAR-YAEVYAVLNDPLTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHT 108 Query: 171 ALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALF-GERLGLVGHSPSSASLN-FLHALE 228 + + + + ++ + L G + + + L+ F A+ Sbjct: 109 RTRAVLSKVLSPATMKRLRDGFAAAADAKIDELLARGGNIDAIADLAEAYPLSVFPDAMG 168 Query: 229 VMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTG 288 + + L+ + P E ++ + + Q P + Sbjct: 169 LKQEGRENLLPYAGLVFNAFGP--PNELRQSAIERSAPHQAYVAEQCQRPNLA-PGGFGA 225 Query: 289 IVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAA 348 + E++ E L + +DTT + ++ LAR PD LR + Sbjct: 226 CIHAFSDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADP---- 281 Query: 349 ASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLY 408 L R A +E +R R + D+ L I G V +FL Sbjct: 282 --------------SLARNAFEEAVRFESPVQTFFRTTTRDVELAGATIGEGEKVLMFLG 327 Query: 409 SLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468 S R+ + P+RY+ R + HV FG G+ C+G+ +A E ++L + Sbjct: 328 SANRDPRRWDDPDRYDITR--------KTSGHVGFGSGVHMCVGQLVARLEGEVVLAALA 379 Query: 469 KHFLVETLTQEDIKMVYSFILRPGTSPLLTFRA 501 + + +K ++ LR S + Sbjct: 380 RKVAAIEIAG-PLKRRFNNTLRGLESLPIQLTP 411 >1EHE-A nrPDB Length = 403 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 59/383 (15%), Positives = 119/383 (31%), Gaps = 45/383 (11%) Query: 120 RQHRGHKCGVFLLNGPEWRFNRLR--LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVL 177 HK F+ + R R S K + P + + V Sbjct: 43 WLVTKHKDVCFVATSEKLSKVRTRQGFPELSASGKQAAKAKPTFVDMDPPEHMHQRSMVE 102 Query: 178 QNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQL 237 ++QP I + E++ G + L AL V L Sbjct: 103 PTFTPEAVKNLQPYIQRTVDDLL------EQMKQKGCANGPVDLVKEFALPVPSYIIYTL 156 Query: 238 MFMPRSLSRWIS---------PKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTG 288 + +P + +++ +E A + Y ++ Q L + + Sbjct: 157 LGVPFNDLEYLTQQNAIRTNGSSTAREASAANQELLDYLAILVE---QRLVEPKDDIISK 213 Query: 289 IVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAA 348 + E + + + L T + + + LA++PD L Sbjct: 214 LCTEQVKPGNIDKSDAVQIAFLLLVAGNATMVNMIALGVATLAQHPDQLAQL-------- 265 Query: 349 ASISEHPQKATTELPLLRAALKETLRLYP-VGLFLERVVSSDLVLQNYHIPAGTLVQVFL 407 L ++E R + L ++R D+++ + + A + Sbjct: 266 ----------KANPSLAPQFVEELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASN 315 Query: 408 YSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHV 467 S R+ +F P+ +N R + + FGFG +C+ LA+AE+ + + Sbjct: 316 QSANRDEEVFENPDEFNMNRKWPPQDP------LGFGFGDHRCIAEHLAKAELTTVFSTL 369 Query: 468 LKHFLVETLTQEDIKMVYSFILR 490 + F + K+ Y+ + R Sbjct: 370 YQKFPDLKVAVPLGKINYTPLNR 392 >4MM0-A nrPDB Length = 399 Score = 153 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 88/465 (18%), Positives = 152/465 (32%), Gaps = 84/465 (18%) Query: 24 LGTRAARAPRTVLPFE-AMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYN 82 + + AA A R PF+ A+P L + RE + + I Sbjct: 1 MASMAASATRHPYPFDRAVPT----AIPPLYEELRET-------------ERVAAI-TMA 42 Query: 83 LGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRL 142 G P + V EDV + D R L A R V + P R Sbjct: 43 TGDPGFL-VTRYEDV-RFVLSDPRFSVRQDLP--GAPRLTEMTFESVMTTDPPVHTRLRR 98 Query: 143 RLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNL 202 L+ D + + ++R P ++ +A ++KK D+ S+ Sbjct: 99 LLSRDFTARR-IERMRPRLEEIAEGLLDEMEKK-------GAPADIVESLAVPFPITVIC 150 Query: 203 ALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDC 262 L G + + + + S+ W A D Sbjct: 151 ELLG--------------VPMVDVARFRGWADTMVSLTGYSMEDW---------TAARDA 187 Query: 263 IFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFP 322 + Y D + + + +VA EL+ +++ S+ L + + Sbjct: 188 LESYLDGLVAAKRENPG---SDLLSALVATAAEDNELTDHDVRSLSLILLLAGYEPASNQ 244 Query: 323 LLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF- 381 L ++ L R PD LR++ LL +A++E +R P G Sbjct: 245 LGSSVLTLLRFPDRLAELRRDP------------------GLLPSAVEELMRYAPAGDGA 286 Query: 382 LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHV 441 L RV D+ + + HIPA + V + + F P R + H Sbjct: 287 LFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDR--------PDNQHT 338 Query: 442 PFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYS 486 G G+ CLG LA E+ + + +L+ F L ++ + +S Sbjct: 339 ALGHGIHFCLGAALARVELQVAIGALLRRFPRLALATDESGLRWS 383 >3P3Z-A nrPDB Length = 416 Score = 151 bits (381), Expect = 8e-37, Method: Composition-based stats. Identities = 59/366 (16%), Positives = 112/366 (30%), Gaps = 39/366 (10%) Query: 144 LNPDVLSPKAVQR--FLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASN 201 L V +P+ R + + ++ + L+ VQP + + + Sbjct: 81 LVDMVGTPEGPVRDFMVDFLQSLDGADHRRLRGLATHPFTPRRITAVQPFVRSTVEQLID 140 Query: 202 LALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ-----LMFMPRSLSRWISPKVWKEH 256 G+ V H P + L + L+ + + Sbjct: 141 KLPQGD-FDFVQHFPHPLPALVMCQLLGFPLEDYDTVGRLSIETNLGLALSNDQDILVKV 199 Query: 257 FEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSV 316 + +F Y I+K E T + L ++ + Sbjct: 200 EQGLGRMFDYLVAAIEKRKVEP----GDDLTSDIVRAFHDGVLDDYELRTLVATVLVAGY 255 Query: 317 DTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLY 376 +TT L + +++ A++PD +++ L A++E LR Sbjct: 256 ETTNHQLALAMYDFAQHPDQWMKIKENPE------------------LAPQAVEEVLRWS 297 Query: 377 PVGLFL-ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG 435 P RV + D + IP GT V + + R+ +F +R++ Sbjct: 298 PTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDIT-------VK 350 Query: 436 RNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSP 495 R + FG G CLG LA E+ + + + E I + + + Sbjct: 351 REAPSIAFGGGPHFCLGTALARLELTEAVAALATRLDPPQIAGE-ITWRHELGVAGPDAL 409 Query: 496 LLTFRA 501 L F A Sbjct: 410 PLRFGA 415 >5NWS-A nrPDB Length = 435 Score = 151 bits (380), Expect = 8e-37, Method: Composition-based stats. Identities = 65/356 (18%), Positives = 116/356 (32%), Gaps = 45/356 (12%) Query: 141 RLRLNPDVLSPKAVQRFLP-MVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEA 199 R + + P+ ++ +L + L++ V + L ++P I Sbjct: 94 REGMMDLLNVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRILGLRPGIERIADRL 153 Query: 200 SNLALFGER----LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKE 255 E + L+ H S+ + L + + ++ W V Sbjct: 154 LAELPRREEEDGTVDLLEHFAYPLSITVICELVGIPATDLE------RWREWGGDLVSMR 207 Query: 256 HFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE------LSLEAIKANSM 309 D C L R T + L++A+ LS + Sbjct: 208 PERLRHSFPVMIDYC-----HRLIEQRRAALTDDLLSELIRAQDDDGGRLSDIETVTMIL 262 Query: 310 ELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAAL 369 L +T+A + L +P +LR++ LL A+ Sbjct: 263 TLVLAGHETSAHLIGNGTAALLTHPGQWALLRKDPA------------------LLPRAV 304 Query: 370 KETLRLY-PVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRW 428 E +R V + R + DL L + G VQ+ L S + + P+R + R Sbjct: 305 HELMRWCGSVHVARLRYATEDLELAGTPVARGDAVQLVLVSANFDPRHYSDPDRLDITR- 363 Query: 429 LDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMV 484 G+ +HV FG G+ CLG LA E + L +L+ + L D ++ Sbjct: 364 ---HQEGQAENHVGFGHGIHYCLGATLARQEGEVALARLLETYPDLALADGDPEVR 416 >5HDI-A nrPDB Length = 404 Score = 151 bits (380), Expect = 8e-37, Method: Composition-based stats. Identities = 49/220 (22%), Positives = 77/220 (35%), Gaps = 25/220 (11%) Query: 259 AWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDT 318 A I + + A + + G +A EL + + L A ++ Sbjct: 189 AAGVALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGES 248 Query: 319 TAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPV 378 TA L ++ LA PD+QQ +R LL A ++ETLR P Sbjct: 249 TAALLGSAVWILATRPDIQQQVRANPE------------------LLGAFIEETLRYEPP 290 Query: 379 GLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNF 438 R V + L +PA + + + + R+ A F P + R Sbjct: 291 FRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKG------ 344 Query: 439 HHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQ 478 H+ FG G C+G LA E ++L +L V Sbjct: 345 -HISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAAD 383 >3A1L-A nrPDB Length = 425 Score = 151 bits (380), Expect = 8e-37, Method: Composition-based stats. Identities = 61/329 (18%), Positives = 112/329 (34%), Gaps = 29/329 (8%) Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALE 228 L+ + S+ ++P I + R LV + + + AL Sbjct: 106 HTELRSLLTTEFSPSIVTGLRPRIAELASALLDRLRAQRRPDLVEGFAAPLPILVISALL 165 Query: 229 VMFKSTVQ-LMFMPRSLSRWISPKVW--KEHFEAWDCIFQYGDNCIQKIYQELAFNRPQH 285 + + L +L + + + + A ++ +++ + +R Sbjct: 166 GIPEEDHTWLRANAVALQEASTTRARDGRGYARAEAASQEFTRYFRREVDRRGGDDRDDL 225 Query: 286 YTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESL 345 T +V + LS++ I + L +TT L + L + DV LR Sbjct: 226 LTLLVRARDTGSPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELRTTPE 285 Query: 346 AAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQV 405 + AA++E +R P + R D+ L ++ IP G+ V Sbjct: 286 S------------------TPAAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVA 327 Query: 406 FLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLH 465 L S R+ A FP P+ + R + V FG G+ CLG LA AE + L Sbjct: 328 LLGSANRDPARFPDPDVLDVHRAAE--------RQVGFGLGIHYCLGATLARAEAEIGLR 379 Query: 466 HVLKHFLVETLTQEDIKMVYSFILRPGTS 494 +L +++ + T Sbjct: 380 ALLDGIPALGRGAHEVEYADDMVFHGPTR 408 >6F0B-A nrPDB Length = 395 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 60/352 (17%), Positives = 121/352 (34%), Gaps = 50/352 (14%) Query: 146 PDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALF 205 ++ Q P + L+ + + ++P+I Sbjct: 68 TELTPTLQSQAAAPPFVRTDNPDHRRLRGTIAREFLPKHIELLRPAIREIVQGV------ 121 Query: 206 GERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWK---------EH 256 L + + + A+ V + +L+ +P ++ V E Sbjct: 122 ---LDGLAETAPPQDMLEAFAVPVASATVFRLLGIPAEDRALLTRCVKGVVSAVGSEDEG 178 Query: 257 FEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSV 316 E + + +Y +Q + + +V + +L+ + L G Sbjct: 179 AEVFRTLGEYIGGLVQDPSELPEDS---LIRRLVTGPYQEKQLTFHETIGVILMLIVGGY 235 Query: 317 DTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLY 376 DTTA + ++L A P+ ++ + PLL ++E LR + Sbjct: 236 DTTASTISLSLVSYALQPEKFSVVHEHPERI---------------PLL---VEELLRYH 277 Query: 377 PVGL-FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG 435 V L R+ + D+ + + AG +V L R+ ++FP P+ + R Sbjct: 278 TVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR-------- 329 Query: 436 RNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL--TQEDIKMVY 485 + HV FG+G QC+G+ LA E+ + V++ L ED+ + Sbjct: 330 PSVPHVGFGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLACALEDLPFRH 381 >1UE8-A nrPDB Length = 367 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 52/316 (16%), Positives = 106/316 (33%), Gaps = 44/316 (13%) Query: 167 DFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHA 226 L+ S P F + L+ E ++ + + Sbjct: 74 PLHDELRNLTADAFNPSNL----PVDFVREVTVKLLSELDEEFDVIESFAIPLPILVISK 129 Query: 227 LEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQ--KIYQELAFNRPQ 284 + + + + S ++ ++ + D IF G ++ ++ +R Sbjct: 130 MLGI----NPDVKKVKDWSDLVALRLGR-----ADEIFSIGRKYLELISFSKKELDSRKG 180 Query: 285 HYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQES 344 + + + LS + + L +TT + + E Sbjct: 181 KEIVDLTGKIANSNLSELEKEGYFILLMIAGNETTTNLIGNAI---------------ED 225 Query: 345 LAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQ 404 S +K + A++E LR P + RV + +++ I G LV+ Sbjct: 226 FTLYNSWDYVREKGALK------AVEEALRFSPPVMRTIRVTKEKVKIRDQVIDEGELVR 279 Query: 405 VFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLL 464 V++ S R+ +F P+ + P R + H+ FG G+ CLG LA E + L Sbjct: 280 VWIASANRDEEVFKDPDSFIPDRTPN--------PHLSFGSGIHLCLGAPLARLEARIAL 331 Query: 465 HHVLKHFLVETLTQED 480 K F V+ + +++ Sbjct: 332 EEFAKKFRVKEIVKKE 347 >5YSW-A nrPDB Length = 441 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 75/441 (17%), Positives = 132/441 (29%), Gaps = 74/441 (16%) Query: 54 QIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPC-RMI 112 + R + H+ + + GP+ R L ++ + + D R Sbjct: 43 EFVRREDPFHVPPALVAVSER-GPVARATLAAGDPFWLVSGYEEARAVLSDPRFSSDRFQ 101 Query: 113 LEPWVAY---------RQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDA 163 PW R + ++ PE R L + ++ +D Sbjct: 102 YHPWFKELSPEFRERLRDDKARAGSFINMDPPEHTRYRKLLTGQFTVRR-IRELGARIDE 160 Query: 164 VARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNF 223 + A+ G T D+ L G R Sbjct: 161 IVAGRVDAMLA-------GGTTADLMTEFAFPAPSLMICELLGVRYEDRAE--------- 204 Query: 224 LHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRP 283 + + +Q+ E + D + + + A Sbjct: 205 ---FQQRASALLQM------------NAPVAEAVKNADALRAFMQALVTDKRANPA---G 246 Query: 284 QHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE 343 +G++ L+ + + + L DTTA L + +F L + P LR + Sbjct: 247 DIISGLIHHAGADPALTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDD 306 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVG-LFLERVVSSDLVLQNYHIPAGTL 402 A A++E LR V + R DL HIPAG+ Sbjct: 307 PSRIAD------------------AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGST 348 Query: 403 VQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLL 462 V V + + R+A +P P+ + R H+ FG G+ QCLG++LA EM Sbjct: 349 VVVSVVATNRDARHWPDPD-LDLTR--------PRGPHLAFGHGVHQCLGQQLARMEMQA 399 Query: 463 LLHHVLKHFLVETLTQEDIKM 483 +L+ L ++ Sbjct: 400 GYAELLRRLPNVRLAVPPEEV 420 >3IVY-A nrPDB Length = 433 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 48/344 (13%), Positives = 102/344 (29%), Gaps = 40/344 (11%) Query: 149 LSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGER 208 ++ + ++ ++ + L+K + + + + + + A Sbjct: 104 IAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAAAGS 163 Query: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGD 268 V L + L + + +F W + E E + Sbjct: 164 GDFVEQVSCELPLQAIAGLLGVPQEDRGKLF------HWSNEMTGNEDPEYAHIDPKASS 217 Query: 269 NCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKAN-----SMELTAGSVDTTAFPL 323 + ++A + ++ + L++A++ E + + + L +TT + Sbjct: 218 AELIGYAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSI 277 Query: 324 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 + A +PD ++ P A E +R + Sbjct: 278 TQGMMAFAEHPDQWEL----------YKKVRP----------ETAADEIVRWATPVTAFQ 317 Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 R D L I G V +F S + +F P +N R + HV F Sbjct: 318 RTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPN--------PHVGF 369 Query: 444 GF-GMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYS 486 G G C+G LA + L+ + V H ++ Sbjct: 370 GGTGAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERLRSG 413 >6GII-A nrPDB Length = 479 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 52/358 (14%), Positives = 116/358 (32%), Gaps = 35/358 (9%) Query: 145 NPDVLSPKAVQRFLPMVDA----VARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEAS 200 P + ++R+ + ++ +++ + +P + A Sbjct: 131 QPSAEVRQVLERYGYAFNRTLVNEDEPMHLERRRVLMEPFASEHLAEHEPMVRELVRRAV 190 Query: 201 NLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPR-----SLSRWISPKVWKE 255 N + R LV + + M + SP+ Sbjct: 191 NRFIDTGRADLVDQMIWEVPFTVALHFLGVDDDDREKMRRFAIAHTVNAFGRPSPEEQLA 250 Query: 256 HFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGS 315 E +Q+ ++K+ + Y+ I + L ++ + + + + Sbjct: 251 VAETVGQFWQFCGEVLEKMRRTADGPGWMRYS-IRQQKLYPDVVTDSYLHSMMQAIIVAA 309 Query: 316 VDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRL 375 +TT F L L + V + + + L+ AA +E LR Sbjct: 310 HETTVFATTNALKTLLEHETVWREICADP------------------SLIPAAAEECLRY 351 Query: 376 YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG 435 R + ++ ++ +P G + + + S ++A F PE ++ R Sbjct: 352 NGPVAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFDIGR-------S 404 Query: 436 RNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGT 493 H+ FG+G QCLGR L EM +++ + + L ++ +++ R Sbjct: 405 NASEHLNFGYGAHQCLGRNLGRMEMQIMIEELSRRLPHMRLAEQRFDYLHNVSFRAPR 462 >1F4U-A nrPDB Length = 368 Score = 149 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 53/330 (16%), Positives = 105/330 (31%), Gaps = 46/330 (13%) Query: 167 DFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHA 226 L+ ++ I T + ++ +V + + Sbjct: 74 PLHDELRSMSADIFSPQKLQTLETFIRETTRSLLD-SIDPREDDIVKKLAVPLPIIVISK 132 Query: 227 LEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHY 286 + + + L + K IF+ G ++ I + Sbjct: 133 ILGLPIEDKEKFKEWSDLVAFRLGKP--------GEIFELGKKYLELIG---YVKDHLNS 181 Query: 287 TGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLA 346 V ++ + LS + L +TT + ++ + R ++ Q +R+E+L Sbjct: 182 GTEVVSRVVNSNLSDIEKLGYIILLLIAGNETTTNLISNSVIDFTRF-NLWQRIREENLY 240 Query: 347 AAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVF 406 A++E LR P + R + L + I G V+V+ Sbjct: 241 LK-------------------AIEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVW 281 Query: 407 LYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHH 466 + S R+ +F E++ P R + H+ FG G+ CLG LA E + + Sbjct: 282 IASANRDEEVFHDGEKFIPDRNPN--------PHLSFGSGIHLCLGAPLARLEARIAIEE 333 Query: 467 VLKHF------LVETLTQEDIKMVYSFILR 490 K F E + E + ++R Sbjct: 334 FSKRFRHIEILDTEKVPNEVLNGYKRLVVR 363 >5HIW-A nrPDB Length = 398 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 87/438 (19%), Positives = 147/438 (33%), Gaps = 75/438 (17%) Query: 67 EMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHK 126 + +E F LG P V+ DV + + R G Sbjct: 21 HLAAAAREHSVYFDEGLGVP---VVLRGADVVAVLRDSETFSTRTYDT---------GIM 68 Query: 127 CGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLP-MVDAVARDFSQALKKKVLQNARGSLT 185 G + G E RL VLSP+ + R+ V VAR + L +K Sbjct: 69 KGALVTLGGEAHTRMRRLFNAVLSPRVISRYEEATVTPVARRVVERLVRKERAELFDDFA 128 Query: 186 LDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLS 245 + + + ALFG + + + + M RS+ Sbjct: 129 ISMPMGVT--------SALFG-----LPEERIAENDALIR-------------KMIRSVV 162 Query: 246 RWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIK 305 P V E A + ++ E+A I ++ + +EA + Sbjct: 163 MPQDPVVVAEGRSAHAAMEAQLREIAER---EVAHPSDTLLGEIARAIVAEGLGGVEACE 219 Query: 306 ANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLL 365 + L GS +TT++ L L L +PD LRQ+ LL Sbjct: 220 GVVLTLILGSYETTSWMLANLLVALLAHPDAMNQLRQQP------------------SLL 261 Query: 366 RAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNP 425 A++E+ R + R V + + + AGT++ + L + + ++PRPE ++ Sbjct: 262 PQAIEESTRWCSSAAGIVRFVEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDI 321 Query: 426 QRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVY 485 R R + FG G+ C+G LA E + + +L+ F ++ + Sbjct: 322 HR--------RPVGMLNFGGGLHYCVGAPLARMEARVGVSLLLERFPALRADP-TVQPTF 372 Query: 486 SFILR------PGTSPLL 497 S R P P L Sbjct: 373 STAPRGAAAFGPDQIPAL 390 >5DE9-A nrPDB Length = 410 Score = 148 bits (373), Expect = 5e-36, Method: Composition-based stats. Identities = 74/413 (17%), Positives = 131/413 (31%), Gaps = 58/413 (14%) Query: 112 ILEPWVAYRQHRGHKCGVFLLNGPEWRF-------NRLRLNPDVLSPKAVQ-RFLPMVDA 163 +P + G + L NG W + RL N +AV R + + Sbjct: 25 DFDPVLTELMREGPVTRISLPNGEGWAWLVTRHDDVRLVTNDPRFGREAVMDRQVTRLAP 84 Query: 164 VARD-----------FSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL-FGERLGL 211 R L++ V V+ E + L G L Sbjct: 85 HFRPARGAVGFLDPPDHTRLRRSVAAAFTARGVERVRERSRGMLDELVDAMLRAGPPADL 144 Query: 212 VGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHF-EAWDCIFQYGDNC 270 S + + L + + S+ W + H E + + Sbjct: 145 TEAVLSPFPIAVICELMGVPATDRH------SMHTWTQLILSSSHGAEVSERAKNEMNAY 198 Query: 271 IQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFEL 330 + + + + T ++ + + E++L ++ L G + L Sbjct: 199 FSDLIGLRSDSAGEDVTSLLGAAVGRDEITLSEAVGLAVLLQIGG-EAVTNNSGQMFHLL 257 Query: 331 ARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYP--VGLFLERVVSS 388 P++ + LR E + A+ E LR P + L R+ Sbjct: 258 LSRPELAERLRSEPE------------------IRPRAIDELLRWIPHRNAVGLSRIALE 299 Query: 389 DLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMR 448 D+ ++ I AG V V + R+ +FP P+R + +R + HV FGFG Sbjct: 300 DVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFERSPN--------PHVSFGFGPH 351 Query: 449 QCLGRRLAEAEMLLLLHHVLKHFL--VETLTQEDIKMVYSFILRPGTSPLLTF 499 C G LA E LL+ VL + ED+ ++R + +T+ Sbjct: 352 YCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGALIRGPEALPVTW 404 >1ODO-A nrPDB Length = 408 Score = 147 bits (371), Expect = 1e-35, Method: Composition-based stats. Identities = 69/432 (15%), Positives = 131/432 (30%), Gaps = 62/432 (14%) Query: 65 HLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQ-QVDSLHPCRMILEPWVAYRQHR 123 H H+T +E GP ++ G + V P +++L D R A+ Sbjct: 17 HHTEHRTLREGGPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDAR-------AHWPAF 69 Query: 124 GHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGS 183 G G W P A+ + + + L++ V Sbjct: 70 GEVVG-------TW-------------PLALWVAVENMFTAYGPNHRKLRRLVAPAFSAR 109 Query: 184 LTLDVQPSIFHYT---IEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240 ++P++ ++ GE + L + + L + + Sbjct: 110 RVDAMRPAVEAMVTGLVDRLAELPAGEPVDLRQELAYPLPIAVIGHLMGVPQDRRDGFRA 169 Query: 241 PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS 300 + + E +++ D I + + LS Sbjct: 170 LVDGV-FDTTLDQAEAQANTARLYEVLDQLIAAKRATPGDDMTSLLIAARDDEGDGDRLS 228 Query: 301 LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT 360 E ++ + + + +TT + + L PD ++R+ + A Sbjct: 229 PEELRDTLLLMISAGYETTVNVIDQAVHTLLTRPDQLALVRKGEVTWAD----------- 277 Query: 361 ELPLLRAALKETLRLYPVGLFLE-RVVSSDLVL-QNYHIPAGTLVQVFLYSLGRNAALFP 418 ++ETLR P L R +D+ L I G + + R+ Sbjct: 278 -------VVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHE 330 Query: 419 RPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL-- 476 + ++ R + H+ FG G+ CLG LA E+ L L + F L Sbjct: 331 DADTFDATRTVKE--------HLAFGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLAD 382 Query: 477 TQEDIKMVYSFI 488 E++ V S I Sbjct: 383 PAEELPPVPSLI 394 >3SN5-A nrPDB Length = 491 Score = 147 bits (371), Expect = 1e-35, Method: Composition-based stats. Identities = 79/483 (16%), Positives = 170/483 (35%), Gaps = 54/483 (11%) Query: 24 LGTRAARAPRTVLPFEAMPQHP-GNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYN 82 + + + R + P N + L + G L + ++ G +F Sbjct: 1 MAKKTSSRRRQTG------EPPLENGLIPYLGCALQFGANPLEF-LRANQRKHGHVFTCK 53 Query: 83 LGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRL 142 L G + + P K+ C W + K P Sbjct: 54 LMGKYVHFITNPLSYHKVL-------CHGKYFDWKKFHFALSAKAFGHRSIDPMDGNTTE 106 Query: 143 RLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGS--LTLDVQPSIFHYTIEAS 200 +N + + +++ + + ++ V N++ + +T + + EA Sbjct: 107 NINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAG 166 Query: 201 NLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAW 260 L +FG L + N + Q + +L + +++ A Sbjct: 167 YLTIFGRDLTRRDTQKAHILNNL--------DNFKQFDKVFPALVAGLPIHMFRTAHNAR 218 Query: 261 DCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTA 320 + + + + + + + + + + + L + LE K + + L A +T Sbjct: 219 EKLAESLRH--ENLQKRESISELISLRMFLNDTLSTFD-DLEKAKTHLVVLWASQANTIP 275 Query: 321 FPLLMTLFELARNPDVQQILRQESLAAA------ASISEHP----QKATTELPLLRAALK 370 +LF++ RNP+ + +E S+ +P Q +LP+L + +K Sbjct: 276 AT-FWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIK 334 Query: 371 ETLRLYPVGLFLERVVSSDLVL----QNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQ 426 E+LRL L + R D L +Y+I ++ ++ + + ++P P + Sbjct: 335 ESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYD 393 Query: 427 RWLDIRGSGR----------NFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL 476 R+LD G + ++++PFG G C GR A E+ L +L +F +E + Sbjct: 394 RYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELI 453 Query: 477 TQE 479 + Sbjct: 454 EGQ 456 >4Z5Q-A nrPDB Length = 423 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 65/405 (16%), Positives = 130/405 (32%), Gaps = 53/405 (13%) Query: 102 QVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPD-VLSPKAVQRFLPM 160 + P R+ L + F+L + + + ++P+AV + Sbjct: 55 LFEDGDPIRVQLPFGEPAWLVTRYDDARFVLTDRRFSRHLATQRDEPRMTPRAVPESILT 114 Query: 161 VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSAS 220 +D L+ V + + I G + A Sbjct: 115 MDP---PDHTRLRTLVSKAFTPRRIESKRAWIGELAAGLVADMKAG---------GAPAE 162 Query: 221 LNFLHALEVMFKSTVQLMFMPRS----LSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQ 276 L +AL + +L+ +P L W + +C+ + D +QK ++ Sbjct: 163 LVGSYALAIPVTVICELLGVPEDDRTRLRGWCDAALSTGELTDEECVQSFMD--LQKYFE 220 Query: 277 ELAFNRPQHYTGIVAELLLKAELSLE-----AIKANSMELTAGSVDTTAFPLLMTLFELA 331 +L R + L++A + + + + + G +TTA + + L Sbjct: 221 DLVKERRAEPRDDLTSALIEARDAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQ 280 Query: 332 RNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL--FLERVVSSD 389 + ++ L + A + AA++E LR P R D Sbjct: 281 QRRELWTRLCADPEA------------------IPAAVEELLRFVPFAANGISPRYALED 322 Query: 390 LVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQ 449 + + + G V V ++ R+ +F + R + H+ FG G Sbjct: 323 MTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVVIDRADN--------RHMVFGHGAHH 374 Query: 450 CLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTS 494 CLG LA E+ L +++ L+ D++ I+R Sbjct: 375 CLGAHLARVELQEALKALVEGMPGLRLSG-DVEWKADMIIRAPRV 418 >4JBT-A nrPDB Length = 410 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 69/408 (16%), Positives = 136/408 (33%), Gaps = 69/408 (16%) Query: 76 GPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCG------- 128 GP+ R +L G + V +L L W + R Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 129 -VFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLD 187 +F ++GPE R R++ L+ + + P ++ + L++ +D Sbjct: 90 SMFTVDGPEHRRLRIK-TTQALTRRRLDALKPTIERYVAELLDDLER----AGADGAVVD 144 Query: 188 VQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKST-VQLMFMPRSLSR 246 ++ + + + AL + QL+ ++ Sbjct: 145 LKSVFAY-----------------------PLPMRVISALMGVPSEDQEQLLTWYKAFFS 181 Query: 247 WISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKA 306 ++P+ E D + Y +++ E + + ++ + L+ E + Sbjct: 182 ILTPQD--ERLRVIDEMHGYFTEMVRRKTAEPGDDLT---SALIYATDGETPLTEEEVIG 236 Query: 307 NSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLR 366 N L A +TT +L + L +P+ +++R + Sbjct: 237 NLQALVAAGHETTVSLILTAVRALLSHPEQLRLVRDGEIGW------------------E 278 Query: 367 AALKETLRLY-PVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALF-PRPERYN 424 A++ETLR PV L R + D+ L + IP G V + ++GR+ + + ++ Sbjct: 279 TAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADDFD 338 Query: 425 PQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFL 472 R H+ FG G C G LA E + L + F Sbjct: 339 ITR-------ATAARHISFGHGPHICPGAALARLEAAIALPALFTRFP 379 >4XE3-A nrPDB Length = 407 Score = 146 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 61/408 (14%), Positives = 113/408 (27%), Gaps = 50/408 (12%) Query: 92 MLPEDVEKLQQVDSLHPCRMILEPWVAY--RQHRGHKCGVFLLNGPEWRFNRL------- 142 P + + P + L+P A R + + G W R+ Sbjct: 6 TGPTPADAVPAYPFSLPHALDLDPHYAELRRDEPVSRVRLPYGEGTAWLVTRMSDARIVL 65 Query: 143 ---RLNPDVLSPKAVQRFLPM------VDAVARDFSQALKKKVLQNARGSLTLDVQPSIF 193 R + + A R P V A L++ V + +++P + Sbjct: 66 GDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFTARRVEEMRPRVR 125 Query: 194 HYTIEASN-LALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKV 252 + + G LV + + L + L + Sbjct: 126 SLVDSLLDDMVAHGSPADLVEFLAVPFPVAVICELLGVPLEDRDLFRTFSDAMLSSTRLT 185 Query: 253 WKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELT 312 E Y D + Q + L+ I + L Sbjct: 186 AAEIQRVQQDFMVYMDGLVA---QRRDAPTEDLLGALALATDNDDHLTKGEIVNMGVSLL 242 Query: 313 AGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKET 372 +T+ + + L + + + L+ AA++E Sbjct: 243 IAGHETSVNQITNLVHLLLT------------------ERKRYESLVADPALVPAAVEEM 284 Query: 373 LRLYPVGLF--LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLD 430 LR P+ RV + D+ L + AG V S R+ +F + + R Sbjct: 285 LRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHADELDFHR--- 341 Query: 431 IRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQ 478 H+ FG G C+G +L E+ L +++ F L + Sbjct: 342 -----ERNPHIAFGHGAHHCIGAQLGRLELQEALSALVRRFPTLDLAE 384 >4DO1-A nrPDB Length = 410 Score = 144 bits (364), Expect = 6e-35, Method: Composition-based stats. Identities = 43/205 (20%), Positives = 76/205 (37%), Gaps = 27/205 (13%) Query: 297 AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ 356 E++ + L + +DTT + ++ LAR P Q LR + Sbjct: 232 GEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPT----------- 280 Query: 357 KATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAAL 416 L R A +E +R R + ++ L I G V +FL S R+ Sbjct: 281 -------LARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRR 333 Query: 417 FPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL 476 + P+ Y+ R + HV FG G+ C+G+ +A E ++L + + + Sbjct: 334 WSDPDLYDITR--------KTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDI 385 Query: 477 TQEDIKMVYSFILRPGTSPLLTFRA 501 +K ++ LR S + Sbjct: 386 DG-PVKRRFNNTLRGLESLPVKLTP 409 >6M7L-A nrPDB Length = 404 Score = 142 bits (358), Expect = 3e-34, Method: Composition-based stats. Identities = 53/309 (17%), Positives = 101/309 (32%), Gaps = 40/309 (12%) Query: 195 YTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWK 254 +E A+ + L + + A + + + + +P + Sbjct: 125 QALEPRVQAIVDDHLDTMASTGPPVEFLREVAGPMAARVACEFLGIPLDDRGELIR--LT 182 Query: 255 EHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLK--AELSLEAIKANSMELT 312 H G + + + A R G++ + A++S E + + Sbjct: 183 AHRGGKRRRVLNGHAYLAYMRELAARLRRDPGDGMLGMVARDHGADISDEELAGLCAVVM 242 Query: 313 AGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKET 372 SV+ T L L +P+ +LR+ L A++E Sbjct: 243 NSSVEQTESCLAAGTLLLLEHPEQFALLRE------------------RPELGEQAVEEI 284 Query: 373 LRLYPVGLFL-ERVVSSDLVLQNYHIPAGTLVQVFLYSLGR-NAALFPRPERYNPQRWLD 430 +R V L R + D+ + I G V L + R + AL + ++ R Sbjct: 285 VRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL----DGFDITR--- 337 Query: 431 IRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILR 490 + HV FG G+ CLG LA E+ + ++ F ++ + R Sbjct: 338 -----KESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRFPSLRTAVPAEEIRF----R 388 Query: 491 PGTSPLLTF 499 P +S + T Sbjct: 389 PPSSNVFTL 397 >6A7I-A nrPDB Length = 411 Score = 141 bits (356), Expect = 5e-34, Method: Composition-based stats. Identities = 47/305 (15%), Positives = 102/305 (33%), Gaps = 40/305 (13%) Query: 192 IFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPK 251 + + ++E GE + L +N + L + + + ++ S + Sbjct: 122 LTNASLEKLAALPAGEPVDLKAEFAYPLPMNVISELMGVDAADHPRLKELFE--KFFSTQ 179 Query: 252 VWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE----LSLEAIKAN 307 E + Q + + + R + + L+ +E L+ E I Sbjct: 180 TPPE------EVPQMMADLGALFTKIVDAKRTNPGDDLTSALIAASENGDHLTDEEIVNT 233 Query: 308 SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRA 367 + A +TT ++ + L +P+ ++ + + Sbjct: 234 LQLIIAAGHETTISLIVNVVEALQTHPEQRKKVLNGEIGW------------------DG 275 Query: 368 ALKETLRL-YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALF-PRPERYNP 425 ++ETLR P L R + D+ + + +P G + + +LGR+ + P ++ Sbjct: 276 VIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQYGPTAGEFDA 335 Query: 426 QRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVY 485 R + H+ FG G C G L+ E + L + + F L + Sbjct: 336 TRTPN--------RHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPASDLRN 387 Query: 486 SFILR 490 I+ Sbjct: 388 KPIVT 392 >6G71-A nrPDB Length = 405 Score = 141 bits (354), Expect = 8e-34, Method: Composition-based stats. Identities = 48/258 (18%), Positives = 104/258 (40%), Gaps = 37/258 (14%) Query: 249 SPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE--LSLEAIKA 306 P VW + ++ D I D ++++ Q ++ + +++ LL A+ + LE+I++ Sbjct: 176 DPDVWAKAKQSSDEI----DAALEEMIQ---WHSGRPGDSLLSYLLRSADYQMPLESIRS 228 Query: 307 NSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLR 366 N G ++ L ++ L + +++ + L Sbjct: 229 NIKMTIGGGLNEPRDVLGVSTLALLSSSKQLELV------------------LRDPKLWG 270 Query: 367 AALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQ 426 A +E++R + R D L Y IP G + + + S R+ +++ P+R++ + Sbjct: 271 AVFEESIRWVAPIGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFDIE 330 Query: 427 RWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEML-LLLHHVLKHFLVETLTQEDIKMVY 485 R + H+ FG G+ CLG A +++ + L + L Sbjct: 331 R--------GSEAHLAFGKGVHVCLGAWAARSQVADVGLPALFSRLKGLRLDPNQEATHG 382 Query: 486 SFILR-PGTSPLLTFRAI 502 ++ R P + PL+ +A+ Sbjct: 383 GWVFRGPLSLPLVWDKAV 400 >6DCD-A nrPDB Length = 424 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 50/248 (20%), Positives = 85/248 (34%), Gaps = 35/248 (14%) Query: 264 FQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLE--AIKANSMELTAGSVDTTAF 321 Q+ D+ ++ +A + E + ++ L A +TTA Sbjct: 200 LQWLDDKFSAYIEDRRRQPRNDVLTALATATYPDGSTPEVIDVVRSATFLFAAGQETTAK 259 Query: 322 PLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF 381 L + L PD+Q+ LR+ L+ ++E+LR+ Sbjct: 260 LLTAAMRVLGDRPDIQRRLRE------------------NRSLIPNFIEESLRMDSPVKS 301 Query: 382 LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHV 441 R+ + I AGT+V V + R+ F P + R H+ Sbjct: 302 DSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR-------PNVREHM 354 Query: 442 PFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL------TQEDIKMVY--SFILRPGT 493 F G+ C G LA E + L +L L + +D + Y ++ILR T Sbjct: 355 AFARGVHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYEPTYILRGLT 414 Query: 494 SPLLTFRA 501 +TF Sbjct: 415 ELHITFTP 422 >6A7J-A nrPDB Length = 411 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 52/302 (17%), Positives = 101/302 (33%), Gaps = 34/302 (11%) Query: 192 IFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPK 251 + + ++E GE + L +N + L + + + ++ S + Sbjct: 122 LTNASLERLAALPAGEPVDLKAEFAYPLPMNVISELMGVDAADHPRLKELFE--KFFSTQ 179 Query: 252 VWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE-LSLEAIKANSME 310 E KI +E N T + + L+ E I Sbjct: 180 TPPEEVPQM---MADLGTLFTKIVEEKKANPGDDLTSALIAASEDGDHLTDEEILNTLQL 236 Query: 311 LTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALK 370 + A +TT ++ + LA +P+ ++ + E P ++ Sbjct: 237 IIAAGHETTISLIVNVVEALAIHPEQRKKVLSG---------EIPW---------EGVIE 278 Query: 371 ETLRL-YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALF-PRPERYNPQRW 428 ETLR P L R + D+ + + +P G + V +LGR+ + P ++ R Sbjct: 279 ETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATRT 338 Query: 429 LDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFI 488 + H+ FG G C G L+ E + L + + F L ++ I Sbjct: 339 PN--------RHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPAAELRNKPI 390 Query: 489 LR 490 + Sbjct: 391 VT 392 >2UUQ-A nrPDB Length = 414 Score = 139 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 53/339 (15%), Positives = 100/339 (29%), Gaps = 41/339 (12%) Query: 167 DFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHA 226 +K V + V+P++ + +E +V + Sbjct: 102 PVHTEFRKLVSRGFTPRQVETVEPTVRKFVVERLEKLRANGGGDIVTELFKPLPSMVVAH 161 Query: 227 LEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHY 286 + + W V + + + L R Sbjct: 162 YLGVPEED------WTQFDGWTQAIVAANAVDGATTGALDAVGSMMAYFTGLIERRRTEP 215 Query: 287 TGIVAELLLKAELSLEAIKANSMELTA-------GSVDTTAFPLLMTLFELARNPDVQQI 339 L+ A + + A ++ + A G DT L ++ L R PD +++ Sbjct: 216 ADDAISHLVAAGVGADGDTAGTLSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRL 275 Query: 340 LRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPA 399 L + + A++E LRL L R + D+ + + IPA Sbjct: 276 LLDDPEG------------------IPDAVEELLRLTSPVQGLARTTTRDVTIGDTTIPA 317 Query: 400 GTLVQVFLYSLGRNAALF-PRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEA 458 G V + S R+ + P + R + + F G CLG A Sbjct: 318 GRRVLLLYGSANRDERQYGPDAAELDVTR--------CPRNILTFSHGAHHCLGAAAARM 369 Query: 459 EMLLLLHHVLKHFLVETLTQEDIKMV-YSFILRPGTSPL 496 + + L +L + + I S++ RP + P Sbjct: 370 QCRVALTELLARCPDFEVAESRIVWSGGSYVRRPLSVPF 408 >3OFT-A nrPDB Length = 396 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 66/349 (18%), Positives = 119/349 (34%), Gaps = 53/349 (15%) Query: 153 AVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLV 212 ++ QA+ +K++++ R + D Sbjct: 101 VMKGLASRFVVALEPKVQAVARKLMESLRPRGSCDFVSDFAE------------------ 142 Query: 213 GHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQ 272 FL ++V + +L + L+R ++ +A D Y I+ Sbjct: 143 ----ILPLNIFLTLIDVPLEDRPRLRQLGVQLTRPDGSMTVEQLKQAAD---DYLWPFIE 195 Query: 273 KIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELAR 332 K +A ++ I++E + +++ + L G +DT A + M LAR Sbjct: 196 K---RMAQPGDDLFSRILSEPVGGRPWTVDEARRMCRNLLFGGLDTVAAMIGMVALHLAR 252 Query: 333 NPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVL 392 +P+ Q++LR+ L+ AA E +R YP + R +D+ Sbjct: 253 HPEDQRLLRERPD------------------LIPAAADELMRRYPTV-AVSRNAVADVDA 293 Query: 393 QNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLG 452 I G LV + + A F PE R L H G G +C+G Sbjct: 294 DGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGL------APIRHTTMGVGAHRCVG 347 Query: 453 RRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRA 501 LA E+++ L L L + + + T+ L +RA Sbjct: 348 AGLARMEVIVFLREWLGGMPEFALAPDKAVTMKGGNVGACTALPLVWRA 396 >2X9P-A nrPDB Length = 404 Score = 134 bits (338), Expect = 7e-32, Method: Composition-based stats. Identities = 55/329 (16%), Positives = 104/329 (31%), Gaps = 41/329 (12%) Query: 163 AVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALF-GERLGLVGHSPSSASL 221 R ++ + L++QP + + + G L G +L Sbjct: 99 ESGRRQHAETRRLLTPLFSARRVLEMQPKVEEAADTLLDAFIAQGPPGDLHGELTVPFAL 158 Query: 222 NFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFN 281 L + + + + + + A D +F Y ++ E Sbjct: 159 TVLCEVIGVPPQRRAELTTLLAGIAKLDDRE--GAVRAQDDLFGYVAGLVEHKRAEPGP- 215 Query: 282 RPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILR 341 + L EL+ + + +M L +D+ A + + LA +PD + Sbjct: 216 -------DIISRLNDGELTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAA-- 266 Query: 342 QESLAAAASISEHPQKATTELPLLRAALKETLRLYPVG--LFLERVVSSDLVLQNYHIPA 399 A + ++ A++E LR G + R S D+ I A Sbjct: 267 ----------------ALADPDVMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRA 310 Query: 400 GTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAE 459 G LV L + F PE ++ R + H+ FG G+ C+G LA E Sbjct: 311 GDLVLFDLGLPNFDERAFTGPEEFDAARTPN--------PHLTFGHGIWHCIGAPLARLE 362 Query: 460 MLLLLHHVLKHFL--VETLTQEDIKMVYS 486 + + + L E +++ Sbjct: 363 LRTMFTKLFTRLPELRPELPVEQLRLKEG 391 >6BLD-A nrPDB Length = 419 Score = 134 bits (337), Expect = 9e-32, Method: Composition-based stats. Identities = 57/346 (16%), Positives = 108/346 (31%), Gaps = 35/346 (10%) Query: 161 VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA-LFGERLGLVGHSPSSA 219 A+ L+K V ++ SI + + G + V H Sbjct: 102 FLAMDPPRHTKLRKLVSAAFTPRQVRRIEDSIKINAKGIVDELRMAGGGVDFVEHCAKEL 161 Query: 220 SLNFLHALEVMFKSTVQLMFMPRS-LSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQEL 278 + L + + ++ + + L W P+ + E +F+ + ++ L Sbjct: 162 PIRTLSDMVGIPEADRERVAHAADALVSWADPR-YLNGREPLAVLFE-NQMYLHQVAASL 219 Query: 279 AFNRPQHYTGIVAELLLKAELSLEAIKANSM-----ELTAGSVDTTAFPLLMTLFELARN 333 A R + L+ AE+ + + + L DTT + L L Sbjct: 220 AAERRDRPGDDLFSALVNAEVDGDRLADADVAAFFVLLAVAGNDTTRQTISHGLKALTDF 279 Query: 334 PDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQ 393 P + L + + A++E +R + R ++D L Sbjct: 280 PSQKAWLLADFDTRIGT-----------------AVEELVRWATPVMTFRRTAAADFELG 322 Query: 394 NYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGR 453 I AG V +F S + F PER + R + + CLG Sbjct: 323 GQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGFGGGG-------VHFCLGA 375 Query: 454 RLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTF 499 LA A++ + +L + + + +F+ S TF Sbjct: 376 HLARAQLRAIFGELLVQLPDIQ-AGDPVYVPGNFV-HAIRSMPCTF 419 >5L1U-A nrPDB Length = 401 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 49/288 (17%), Positives = 97/288 (33%), Gaps = 32/288 (11%) Query: 206 GERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDC-IF 264 E L + S L+ + + + L+ +P + ++ + Sbjct: 124 DELLDQLAASAPPVDLHRVLSFRLPTMVVCDLLGVPLADRERFGQWARGTFDQSDNEHSA 183 Query: 265 QYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE--LSLEAIKANSMELTAGSVDTTAFP 322 + + + +A R + I++EL+ + + LS I + +TT Sbjct: 184 NTFQQVVDYMLELVARKRVEPGDDILSELIAEKDGALSDADIAHLGNAVLLFGYETTIVR 243 Query: 323 LLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRL----YPV 378 + + L RNP + L ++ L AA++E LRL Sbjct: 244 IDLGTLLLLRNPVQRAQLAEDP------------------GLAPAAVEEILRLGVGGKGS 285 Query: 379 GLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNF 438 + R D+ + I G V + + + + FP ++ R R Sbjct: 286 NALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLTR-------VRPR 338 Query: 439 HHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYS 486 H+ FG G R C+GR LA E+ + + + L + + + Sbjct: 339 SHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLRWQ 386 >1Q5D-A nrPDB Length = 419 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 58/342 (16%), Positives = 115/342 (33%), Gaps = 42/342 (12%) Query: 168 FSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHAL 227 ++K V + ++ I + + E +V + + AL Sbjct: 102 DHARVRKLVNPSFTSRAIDLLRAEIQRTVDQLLDARSGQEEFDVVRDYAEGIPMRAISAL 161 Query: 228 EVMFKS-TVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHY 286 + + + +R + + E + + ++ L R Sbjct: 162 LKVPAECDEKFRRFGSATARALGVGLVPRVDEETKTLVASVTEGLALLHGVLDERRRNPL 221 Query: 287 TGIVAELLLKAE-----LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILR 341 V +LL+AE LS + + A + A DTT + + + L R+P+ ++++ Sbjct: 222 ENDVLTMLLQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVK 281 Query: 342 QESLAAAASISEHPQKATTELPLLRAALKETLRLYPVG-LFLERVVSSDLVLQNYHIPAG 400 E L+R AL E LR + + R DL I G Sbjct: 282 AEP------------------GLMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKG 323 Query: 401 TLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEM 460 +V + + S R+ +F RP+ ++ +R + +G G C G LA E Sbjct: 324 EMVFLLIPSALRDGTVFSRPDVFDVRR--------DTSASLAYGRGPHVCPGVSLARLEA 375 Query: 461 LLLLHHVLKHFLVETLTQEDIKMVY---------SFILRPGT 493 + + + + F L + + + + IL+P Sbjct: 376 EIAVGTIFRRFPEMKLKETPVFGYHPAFRNIESLNVILKPSK 417 >1GWI-A nrPDB Length = 411 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 47/278 (16%), Positives = 95/278 (34%), Gaps = 37/278 (13%) Query: 219 ASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQEL 278 L ++M +L + ++ S + E + + + Sbjct: 149 YPLPMYVVADLMGIEEARLPRLKVLFEKFFSTQTPPE------EVVATLTELASIMTDTV 202 Query: 279 AFNRPQHYTGIVAELLLKAE----LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNP 334 A R + + L+ +E L+ I + + A +TT ++ + L+ +P Sbjct: 203 AAKRAAPGDDLTSALIQASENGDHLTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHP 262 Query: 335 DVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLY-PVGLFLERVVSSDLVLQ 393 + + ++ + A ++ETLR P L R + D+ + Sbjct: 263 EQRALVLSGEAEWS------------------AVVEETLRFSTPTSHVLIRFAAEDVPVG 304 Query: 394 NYHIPAGTLVQVFLYSLGRNAALF-PRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLG 452 + IPAG + V +LGR+ P +R++ R H+ FG G C G Sbjct: 305 DRVIPAGDALIVSYGALGRDERAHGPTADRFDLTRTSG-------NRHISFGHGPHVCPG 357 Query: 453 RRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILR 490 L+ E + L + F L ++ ++ Sbjct: 358 AALSRMEAGVALPALYARFPHLDLAVPAAELRNKPVVT 395 >2WIY-A nrPDB Length = 394 Score = 128 bits (321), Expect = 6e-30, Method: Composition-based stats. Identities = 39/236 (16%), Positives = 82/236 (34%), Gaps = 24/236 (10%) Query: 262 CIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAF 321 F Y + ++ ++ N + + E++ A + A + Sbjct: 181 VAFGYLSARVAEMLEDKRVNPGDGLADSLLDAARAGEITESEAIATILVFYAVGHMAIGY 240 Query: 322 PLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF 381 + + AR P+V R + A A A + E +R+ P L Sbjct: 241 LIASGIELFARRPEVFTAFRNDESARA------------------AIINEMVRMDPPQLS 282 Query: 382 LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHV 441 R + D+ + I AG+ ++ + + R+ +F P+ ++ R ++ Sbjct: 283 FLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR------PPAASRNL 336 Query: 442 PFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLL 497 FG G C G+ ++ AE + + + + L +E F R P++ Sbjct: 337 SFGLGPHSCAGQIISRAEATTVFAVLAERYERIELAEEPTVAHNDFARRYRKLPIV 392 >5D3U-A nrPDB Length = 427 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 57/290 (19%), Positives = 91/290 (31%), Gaps = 41/290 (14%) Query: 226 ALEVMFKSTVQLMFMPRSLSRWISPKV---------WKEHFEAWDCIFQYGDNCIQKIYQ 276 A E+ +S V +P ++ P+V K+ + I + + + Sbjct: 164 AAELPVRSAVHAFGVPEEDLGFLIPRVNTIMTYFSGPKDQPVTQEIILEKLTDLHTYASE 223 Query: 277 ELAFNRPQHYTGIVAELLLKA-----ELSLEAIKANSMELTAGSVD-TTAFPLLMTLFEL 330 L R + V L A E + E + TT L Sbjct: 224 LLQGMRGKVLPDTVIARLAAAQDGLTETTPEQTVHQLALVFIALFAPTTPGSLSSGTLAF 283 Query: 331 ARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDL 390 ARNP + + E LR F RV + D+ Sbjct: 284 ARNPRQVERFLADQACV------------------DNTANEVLRYNASNQFTWRVAAKDV 325 Query: 391 VLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQC 450 + I AG + +FL S R+A +F RP ++ R + H+ FG G+ C Sbjct: 326 EMGGVRIEAGQTLALFLGSANRDANMFERPNDFDLDR-------PNSARHLSFGQGVHAC 378 Query: 451 LGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFR 500 L +L ++ +L F E I + R S L+ R Sbjct: 379 LAAQLISLQLKWFYVALLNRFPGIRTAGEPI-WNENLEFRSLRSLPLSLR 427 >1WIY-A nrPDB Length = 389 Score = 126 bits (315), Expect = 3e-29, Method: Composition-based stats. Identities = 74/365 (20%), Positives = 125/365 (34%), Gaps = 66/365 (18%) Query: 128 GVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLD 187 G+ G W+ R L L M + F + R D Sbjct: 78 GLLTDWGKSWKEARKALKDPFLPKSVRGYREAMEEEAWAFFGE-----WRGEER-----D 127 Query: 188 VQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRW 247 + + ++ ALFG+ L S + + L AL+ + T + + + Sbjct: 128 LDHEMLALSLRLLGRALFGKPLS------PSLAEHALKALDRIMAQTRSPLALLDLAAEA 181 Query: 248 ISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKAN 307 K + + + + + L E + Sbjct: 182 RFRKDRGALYREAEALIVHPPL---------------------------SHLPRERALSE 214 Query: 308 SMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRA 367 ++ L +T A L + L+ PD Q+ + + AA A+ Sbjct: 215 AVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALAA----------------- 257 Query: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 +E LRLYP L R + L+L +P GT + + Y R FP E + P+R Sbjct: 258 -FQEALRLYPPAWILTRRLERPLLLGEDRLPQGTTLVLSPYVTQR--LYFPEGEAFQPER 314 Query: 428 WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSF 487 +L RG+ + + PFG G R CLGR A E ++L + F ++ L +++ Sbjct: 315 FLAERGTP-SGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLDPLP--FPRVLAQV 371 Query: 488 ILRPG 492 LRP Sbjct: 372 TLRPE 376 >2NZA-A nrPDB Length = 413 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 43/246 (17%), Positives = 83/246 (33%), Gaps = 31/246 (12%) Query: 258 EAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVD 317 EA + + I + + A + ++ + + E+ + L G + Sbjct: 189 EAAERAKRGLYGWITETVRARAGSEGGDVYSMLGAAVGRGEVGETEAVGLAGPLQIGG-E 247 Query: 318 TTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYP 377 + L+ L ++ +R+ A AL E LR Sbjct: 248 AVTHNVGQMLYLLLTRRELMARMRERPGARG------------------TALDELLRWIS 289 Query: 378 --VGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG 435 + L R+ D+ + I AG V V + R+ +FP P+R + R + Sbjct: 290 HRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDRDPN----- 344 Query: 436 RNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFL--VETLTQEDIKMVYSFILRPGT 493 H+ +G G C G LA + LL+ +L+ + E + ++R Sbjct: 345 ---PHLAYGNGHHFCTGAVLARMQTELLVDTLLERLPGLRLAVPAEQVAWRRKTMIRGPR 401 Query: 494 SPLLTF 499 + T+ Sbjct: 402 TLPCTW 407 >3BUJ-A nrPDB Length = 397 Score = 125 bits (313), Expect = 5e-29, Method: Composition-based stats. Identities = 50/320 (15%), Positives = 100/320 (31%), Gaps = 27/320 (8%) Query: 141 RLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEAS 200 R V + ++ L+ V S ++P I + Sbjct: 59 RRFWTDLVGPGLLAEIVGDIILFQDEPDHGRLRGVVGPAFSPSALRRLEPVIAGTVDDLL 118 Query: 201 NLALFGERLGLVGHSPSSASLNFLHALEVMFKST-VQLMFMPRSLSRWISPKVWKEHFEA 259 AL + +V +L + L + + + R + R + E Sbjct: 119 RPALARGAMDVVDELAYPLALRAVLGLLGLPAADWGAVGRWSRDVGRTLDRGASAEDMRR 178 Query: 260 WDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTT 319 + +++ + ++ + + +S I + + +T Sbjct: 179 GHAAIAEFADYVERALARRRREGGEDLLALMLDAHDRGLMSRNEIVSTVVTFIFTGHETV 238 Query: 320 AFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVG 379 A + + L +PD +LR+ LL A++E LR P Sbjct: 239 ASQVGNAVLSLLAHPDQLDLLRRRPD------------------LLAQAVEECLRYDPSV 280 Query: 380 LFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFH 439 R + D+ L+ + +V V + R+ + RP+ ++ +R Sbjct: 281 QSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIER--------DPVP 332 Query: 440 HVPFGFGMRQCLGRRLAEAE 459 + FG GMR CLG LA + Sbjct: 333 SMSFGAGMRYCLGSYLARTQ 352 >3OO3-A nrPDB Length = 384 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 56/355 (15%), Positives = 117/355 (32%), Gaps = 44/355 (12%) Query: 152 KAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIE---ASNLALFGER 208 + P+ D R + + L V P+ +E + E Sbjct: 58 ERFSSMRPVDDEADRALLPGILQAYDPPDHTRLRRTVAPAYSARRMERLRPRIEEIVEEC 117 Query: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGD 268 L + A + + + +PR +S + +E E+ + Sbjct: 118 LDDFESVGAPVDFVRHAAWPIPAYIACEFLGVPRDDQAELSRMI-RESRESRLPRQRTLS 176 Query: 269 NC--IQKIYQELAFNRPQHYTGIVAELLLK--AELSLEAIKANSMELTAGSVDTTAFPLL 324 + + + R G++ ++ + AE+S E + + + + A L Sbjct: 177 GLGIVNYTKRLTSGKRRDPGDGMIGVIVREHGAEISDEELAGLAEGNLIMAAEQMAAQLA 236 Query: 325 MTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVG-LFLE 383 + + L +PD +LR+ + L+ +A +E LR + Sbjct: 237 VAVLLLVTHPDQMALLRE------------------KPELIDSATEEVLRHASIVEAPAP 278 Query: 384 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 443 RV +D+ + I AG ++ + + R +R++ R H+ F Sbjct: 279 RVALADVRMAGRDIHAGDVLTCSMLATNRAP-----GDRFDITR--------EKATHMAF 325 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLT 498 G G+ C+G LA ++ + L V+ F L + + + +PG Sbjct: 326 GHGIHHCIGAPLARLQLRVALPAVVGRFPSLRLAVPEEDLRF----KPGRPAPFA 376 >2IJ7-A nrPDB Length = 396 Score = 123 bits (309), Expect = 2e-28, Method: Composition-based stats. Identities = 67/366 (18%), Positives = 122/366 (33%), Gaps = 53/366 (14%) Query: 143 RLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNL 202 RLN + P+ V + DA L+K V++ P + + + +N Sbjct: 72 RLNALTVPPEVVNNMGNIADA-------GLRKAVMKAITPK-----APGLEQFLRDTANS 119 Query: 203 ALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDC 262 L + + A L A + +++ +P+ + + + D Sbjct: 120 LL-----DNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADP 174 Query: 263 IFQYGDNCIQKI-YQELAFNRPQHYTGIVAELLL------KAELSLEAIKANSMELTAGS 315 I N + I Y P TG++ EL + +S E + Sbjct: 175 IPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAG 234 Query: 316 VDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRL 375 V +T L L L + P ++ +L + + L+ A ++E LR+ Sbjct: 235 VISTGSFLTTALISLIQRPQLRNLLHE------------------KPELIPAGVEELLRI 276 Query: 376 -YPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS 434 L R+ ++D+ + + + G LV V L + FP P R Sbjct: 277 NLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDR------- 329 Query: 435 GRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILR---P 491 H+ FG G C G L + + +LK L ++V+ + P Sbjct: 330 PNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIP 389 Query: 492 GTSPLL 497 P+L Sbjct: 390 ERLPVL 395 >3WEC-A nrPDB Length = 419 Score = 122 bits (307), Expect = 3e-28, Method: Composition-based stats. Identities = 49/293 (16%), Positives = 90/293 (30%), Gaps = 35/293 (11%) Query: 210 GLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDN 269 V + L ++ + +L + + E D + Sbjct: 147 DAVSEVAEPFPVEVLSSILGIPDKDRGRFSEWSNLVAGVLDINFAIPKEVADRRSAAIEE 206 Query: 270 CIQKIYQELAFNRPQHYTGIVAELLL----KAELSLEAIKANSMELTAGSVDTTAFPLLM 325 I Y G+V L +LS++ I A + +T +TT+ + Sbjct: 207 SID--YFRTLATSGNAPEGLVRRLSEVSHGGDQLSVDEIAATCLLITVAGQETTSNTIGN 264 Query: 326 TLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERV 385 L +R+ D + +R + A+ E LR P R+ Sbjct: 265 MLITFSRHADQFEQVRANPQ------------------FIENAVAEVLRFEPPAHEAGRI 306 Query: 386 VSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGF 445 D + +I G V V L S R R + ++ R + + +G Sbjct: 307 ALEDCEVSGANITKGDAVMVLLASGNR--EAVERGDTFSVTR--------PDVSSLSYGR 356 Query: 446 GMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLT 498 G+ CLG LA + + L + + + + E I LR + + Sbjct: 357 GIHHCLGSALANSMLQHFLRELSQRYRSIEVA-EPINYKPGMGLRGPETLSVA 408 >6FYJ-A nrPDB Length = 421 Score = 122 bits (306), Expect = 4e-28, Method: Composition-based stats. Identities = 77/466 (16%), Positives = 143/466 (30%), Gaps = 74/466 (15%) Query: 39 EAMPQHPGNRWLRLLQIWR--EQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPED 96 MP+ G + WR E+GY ++ H IF L G + +C+ E Sbjct: 7 NQMPREEG-----IDSTWRLMEEGYMYILNRRHSFNS---DIFETRLLGKKAICMGGKEA 58 Query: 97 VEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQR 156 E + R P Q K GV L+G +R + ++SP +++ Sbjct: 59 AEIFYDTEKFK--RKDAAPNRVV-QTLFGKNGVQALDGQT-HKHRKEMFMSIMSPDELEK 114 Query: 157 FLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNL--ALFGERLGLVGH 214 + KK+ +D + ++ E + + + + Sbjct: 115 -----------LTDITKKQWEIAVDKWEQMD-KVILYEEAKEIMCRTACQWA-GVPVQEN 161 Query: 215 SPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKI 274 + N E L W+ + + E W I + D Sbjct: 162 EVKRLTKNLGAMFESAAA---------VGLKHWLGRHA-RNYEEIW--IEELIDRVRDGK 209 Query: 275 YQELAFNRPQHYT--GIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELAR 332 ++ + LL E + + + A A + L Sbjct: 210 VNPPENTTLHKFSWYRDLEGNLLDTETAAVEVINILRPIVA-----IAIFINFIALALHH 264 Query: 333 NPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVL 392 P+ ++ L+ + + ++E R YP F+ +V D Sbjct: 265 YPEEKEKLKSG-----------------DKKYSQMFVQEVRRFYPFFPFVVALVKKDFTW 307 Query: 393 QNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGM----R 448 + Y GTL + LY + ++ P+ ++P R+ GS F +P G G Sbjct: 308 KGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEGS--PFSFIPQGGGDYFMGH 365 Query: 449 QCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTS 494 +C G + M + L ++ E D + +S P Sbjct: 366 RCAGEWVTIEVMKVSLDYLTNRMDYEVP---DQDLSFSMASMPSIP 408 >5YHJ-A nrPDB Length = 413 Score = 121 bits (304), Expect = 6e-28, Method: Composition-based stats. Identities = 81/426 (19%), Positives = 156/426 (36%), Gaps = 70/426 (16%) Query: 78 IFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEW 137 IF L G R++C+ E E D+ R P + G GV L+G E Sbjct: 36 IFESRLLGERVICLGGEEAAEVFY--DANKFTRQDAAPKRLLKTLFGE-GGVQTLDGSE- 91 Query: 138 RFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTI 197 +R ++ +++ + + R L + + ++ VL + + + ++ ++ Sbjct: 92 HTHRKQMFMSLMTKENIDRLLRLTYREWNQIERMGEEIVLYDIAQEV---LMKAVCEWSG 148 Query: 198 EASNLALFGER---LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSL-SRWISPKVW 253 G+R + L+ S +S +L + + V + M + + S + P Sbjct: 149 VPLAKEEVGKRTEEMRLLFESGTSLGPTYLQGRKARSSAEVWIRQMVKEVRSNRLLPNEH 208 Query: 254 KEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTA 313 +E +++R + EL E + A + Sbjct: 209 TALYE-------------------FSWHRDE-----------SGELLPEEVVAVEVLNIL 238 Query: 314 GSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETL 373 + +L T+ L + PDV++ + E + + TE ++E Sbjct: 239 RPTVAISVYVLFTVLALHQFPDVKEQV------------ERGEVSKTE------FVQEVR 280 Query: 374 RLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRG 433 R YP V +D Y P GTL + LY + +++ P+R++P R+ D + Sbjct: 281 RFYPFFPVAAARVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRFKDWKE 340 Query: 434 SGRNFHHVPFGFGM----RQCLGRRLAEAEMLLLLHHVLKHFLVETL-TQEDIKMVYSFI 488 S F+ +P G G +C G + + +L V++ F E T + YSF+ Sbjct: 341 S--PFNFIPQGGGDVDFGHRCAGEHV----TIAILAQVIELFTKEYAYTVPPQDLSYSFV 394 Query: 489 LRPGTS 494 P Sbjct: 395 DMPSLP 400 >4FB2-A nrPDB Length = 398 Score = 119 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 60/392 (15%), Positives = 124/392 (31%), Gaps = 46/392 (11%) Query: 92 MLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSP 151 P + + ++ E + + G+K ++ + N+ P + Sbjct: 19 GTPHAFFEALRDEAETTPIGWSEAYGGHWVVAGYKEIQAVIQNTKAFSNKGVTFPRYETG 78 Query: 152 KAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGL 211 + D V + + Q + K A T ++ S I+A G+ Sbjct: 79 EFELMMAGQDDPVHKKYRQLVAKPFSPEATDLFTEQLRQSTNDL-IDARIELGEGDAATW 137 Query: 212 VGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWK-EHFEAWDCIFQYGDNC 270 + + + L+ +P VW H E + + Sbjct: 138 LANEIPARLTAI-------------LLGLPPEDGDTYRRWVWAITHVENPEEGAEIFAEL 184 Query: 271 IQKIYQELAFNRPQHYTGI----VAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMT 326 + +A R I + + LS + + L G +D TA L Sbjct: 185 VAHARTLIAERRTNPGNDIMSRVIMSKIDGESLSEDDLIGFFTILLLGGIDNTARFLSSV 244 Query: 327 LFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVV 386 + LA + ++++ L L+ A+ E LR Y + + R+V Sbjct: 245 FWRLAWDIELRRRL------------------IAHPELIPNAVDELLRFYGPAM-VGRLV 285 Query: 387 SSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFG 446 + ++ + + + G ++ R+ + F P+ +R + H+ G G Sbjct: 286 TQEVTVGDITMKPGQTAMLWFPIASRDRSAFDSPDNIVIERTPN--------RHLSLGHG 337 Query: 447 MRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQ 478 + +CLG L E + + LK +L Sbjct: 338 IHRCLGAHLIRVEARVAITEFLKRIPEFSLDP 369 >5HH3-A nrPDB Length = 397 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 50/325 (15%), Positives = 102/325 (31%), Gaps = 46/325 (14%) Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHAL- 227 L++ V QP + ++ + ++F+ Sbjct: 99 HTRLRRMVAPAFAVRRMQKFQPQVERVVQDSLDAI-----------EALGGPVDFVPRFG 147 Query: 228 -EVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHY 286 V +T + +PR ++ + E N ++ + Sbjct: 148 WSVATTATCDFLGIPRDDQADLARSLHASRTERSGKRRTAAGNKFMTYMNKMTARTRRDP 207 Query: 287 TGIVAELLLK---AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQE 343 + ++++ E++ + + + D A L + +A +P+ +LR++ Sbjct: 208 GDDMFGVVVREYGDEITDAELTGVAAFVMGAGADQVARFLAAGAWLMADDPEQFALLREK 267 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPV-GLFLERVVSSDLVLQNYHIPAGTL 402 L E +R RV + D+ + ++ I AG Sbjct: 268 PDTV------------------PDWLDEVIRYLTTDEKTHPRVATDDVRIGDHLIKAGDT 309 Query: 403 VQVFLYSLGRNAALFPRP-ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEML 461 V L + R FPRP +R++ R H+ FG G+ CLGR LAE Sbjct: 310 VTCSLLAANR--RNFPRPEDRFDITR--------VRPEHLAFGHGIHHCLGRSLAELVFR 359 Query: 462 LLLHHVLKHFLVETLTQEDIKMVYS 486 + + F L + ++ Sbjct: 360 TAIPALAHRFPTLRLAEPHREIRLG 384 >5M0P-A nrPDB Length = 428 Score = 114 bits (286), Expect = 6e-26, Method: Composition-based stats. Identities = 65/419 (15%), Positives = 135/419 (32%), Gaps = 69/419 (16%) Query: 78 IFRYN-LGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPE 136 +F+ LGG V V E E D + M+ + V K + ++G + Sbjct: 41 VFQTKALGGKPFVVVTGKEGAEMFYNNDVVQREGMLPKRIV---NTLAGKGAIHTVDGKK 97 Query: 137 WRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYT 196 +R L F+ ++ ++ + L + + + ++ + Y Sbjct: 98 -HVDRKAL------------FMSLMTEGNLNYVRELTRTLWHAN--TQRMESMDEVNIYR 142 Query: 197 IEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEH 256 L G R V P +++M S L + Sbjct: 143 ESIVLLTKVGTRWAGVQAPPEDIE-RIATDMDIMIDSFRALGGAFKG------------- 188 Query: 257 FEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEA---IKANSMELTA 313 ++A + ++ +++ E G E L + +++L Sbjct: 189 YKASKEARRRVEDWLEEQIIETRKGNIHPPEGTALYEFAHWEDYLGNPMDSRTCAIDLM- 247 Query: 314 GSVDTTAFPL------LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRA 367 +T + L + NP ++ ++ E Sbjct: 248 ---NTFRPLIAINRFVSFGLHAMNENPITREKIKSEPD------------------YAYK 286 Query: 368 ALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 427 +E R YP FL D+ Q IPAG + + +Y + +L+ P + P+R Sbjct: 287 FAQEVRRYYPFVPFLPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPER 346 Query: 428 WLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVE---TLTQEDIKM 483 + GS F +P G G R E ++++ +K+F + + ++D+++ Sbjct: 347 FETWDGS--PFDLIPQGGGDYWTNHRCAGEWITVIIMEETMKYFAEKITYDVPEQDLEV 403 >2IAG-A nrPDB Length = 482 Score = 111 bits (278), Expect = 5e-25, Method: Composition-based stats. Identities = 92/496 (18%), Positives = 176/496 (35%), Gaps = 61/496 (12%) Query: 43 QHPGNRWLRLLQIWREQGY-----EHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDV 97 + PG L L I GY + + + ++ G IF +GG + ++ P Sbjct: 3 RRPGEPPLDLGSIPW-LGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSY 61 Query: 98 EKLQQVDSLHPCRMILEPWVAYRQHRGHKCGV-FLLNGPEWRFNRLRLNPDVLSPKAVQR 156 + V R+ + + R + E +L L + Sbjct: 62 DA---VVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTL--------LHRE 110 Query: 157 FLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSP 216 + +A+ + L + G + + + + + A L L+G + + + Sbjct: 111 LQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYG--IEALPRTH 168 Query: 217 SSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQ 276 S + + +H+ +V F + QL + L+R K+H + + + K+ Sbjct: 169 ESQAQDRVHSADV-FHTFRQLDRLLPKLARGSLSVGDKDHMCS-------VKSRLWKLLS 220 Query: 277 ELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFP---LLMTLFELARN 333 R H + + LL E + + + L T L L +N Sbjct: 221 PARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKN 280 Query: 334 PDVQQILRQESLAAAASISEH-------PQKATTELPLLRAALKETLRLYPVGLFLERVV 386 P+ +R E + + PQK P+L + L E+LRL F+ R V Sbjct: 281 PEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPFITREV 339 Query: 387 SSDLVL-----QNYHIPAGTLVQVFL-YSLGRNAALFPRPERYNPQRWLDIRGSGRNFHH 440 DL + + +++ G + +F S R+ ++ PE + R+L+ GS + + Sbjct: 340 VVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFY 399 Query: 441 ----------VPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL-----TQEDIKMVY 485 +P+G G CLGR A + + VL H +E + E Y Sbjct: 400 KDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRY 459 Query: 486 SF-ILRPGTSPLLTFR 500 F +++P + +R Sbjct: 460 GFGLMQPEHDVPVRYR 475 >5EX8-A nrPDB Length = 424 Score = 107 bits (268), Expect = 8e-24, Method: Composition-based stats. Identities = 37/258 (14%), Positives = 79/258 (30%), Gaps = 31/258 (12%) Query: 233 STVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAE 292 +T + +PR ++ + + D N ++ + + Sbjct: 181 ATCDFLGIPRDDQADLARILLASRTDRSDKRRTAAGNKFMTYMKQHVAQSRRGSGDDLFG 240 Query: 293 LLLKAE---LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAA 349 ++ + ++ + + + + D A L + + P +LR++ Sbjct: 241 IVGRENGDAITDAELTGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLREKPETV-- 298 Query: 350 SISEHPQKATTELPLLRAALKETLRLYPV-GLFLERVVSSDLVLQNYHIPAGTLVQVFLY 408 L ET+R RV + D+ + N + AG V L Sbjct: 299 ----------------PEWLDETMRYLTTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLL 342 Query: 409 SLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468 + R + ++ R H+ FG G+ CLGR +AE + + + Sbjct: 343 AANR-PNYPSAEDEFDITR--------EKAEHLAFGHGIHHCLGRAMAELMFKVSIPALA 393 Query: 469 KHFLVETLTQEDIKMVYS 486 F L ++ Sbjct: 394 HRFPTLRLADPQREITLG 411 >5OMS-A nrPDB Length = 409 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 57/354 (16%), Positives = 109/354 (30%), Gaps = 50/354 (14%) Query: 118 AYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVL 177 A + GH + + NG R + P + + + +V +AR + + + Sbjct: 72 AGGRTFGHPAIIGV-NGDIHADLRSMVEPALQPAEVDRWIDDLVRPIARRYLERFEN--- 127 Query: 178 QNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQL 237 D + E ++ G+ LGL F + V Sbjct: 128 ---------DGHAELVAQYCEPVSVRSLGDLLGLQEVDSDKLREWFAKLNRSFTNAAVD- 177 Query: 238 MFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKA 297 + +P+ + E +A I D I K + + H+ + + + Sbjct: 178 -----ENGEFANPEGFAEGDQAKAEIRAVVDPLIDKWIEHPDDSAISHW---LHDGMPPG 229 Query: 298 EL-SLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ 356 + E I G++ + TL L P+ + + + Sbjct: 230 QTRDREYIYPTIYVYLLGAMQEPGHGMASTLVGLFSRPEQLEEVVDDPT----------- 278 Query: 357 KATTELPLLRAALKETLRLYPVGL-FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAA 415 L+ A+ E LR R+ + + + +PAGT V + S + Sbjct: 279 -------LIPRAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLSYGSANHDTG 331 Query: 416 LFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 + P +Y+ R H+ FG G C G A M + L + + Sbjct: 332 KYEAPSQYDLHR--------PPLPHLAFGAGNHACAGIYFANHVMRIALEELFE 377 >3NV6-A nrPDB Length = 452 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 63/366 (17%), Positives = 122/366 (33%), Gaps = 40/366 (10%) Query: 141 RLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEAS 200 R L +A +++ + + +K + + + V+ + Sbjct: 116 RFSSEVIFLPKEAGEKYQMVPTKMDPPEHTPYRKALDKGLNLAKIRKVEDKVREVASSLI 175 Query: 201 NLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWIS--PKVWKEHFE 258 + G +A L + V + LS + + E Sbjct: 176 ------DSFAARGECDFAAEYAELFPVHVFMALADLPLEDIPVLSEYARQMTRPEGNTPE 229 Query: 259 AWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIK-----ANSMELTA 313 + G+N + R + L++ +E++ E I L Sbjct: 230 EMATDLEAGNNGFYAYVDPIIRARVGGDGDDLITLMVNSEINGERIAHDKAQGLISLLLL 289 Query: 314 GSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETL 373 G +DT L + LAR+P++ LR + L L+R A +E Sbjct: 290 GGLDTVVNFLSFFMIHLARHPELVAELRSDP-----------------LKLMRGA-EEMF 331 Query: 374 RLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRG 433 R +PV R+V+ D + + G ++ + G + A P P + + R Sbjct: 332 RRFPVV-SEARMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSR------ 384 Query: 434 SGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGT 493 R+ H FG G +C G LA E+++ L LK + + + + +S I+ Sbjct: 385 --RSISHSTFGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPIYHSGIVAAVE 442 Query: 494 SPLLTF 499 + L + Sbjct: 443 NVPLVW 448 >2ZQJ-A nrPDB Length = 417 Score = 104 bits (260), Expect = 8e-23, Method: Composition-based stats. Identities = 66/442 (14%), Positives = 135/442 (30%), Gaps = 63/442 (14%) Query: 61 YEHLHLEMHQTFQEL-GPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAY 119 + +L + + +F+ L G +C+ E + D R + + Sbjct: 18 LKEGYLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAKVFYDTD-----RFQRQNALPK 72 Query: 120 RQHRGHKCGVFLLNG--PEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVL 177 R + GV + G +R L +++P +R ++ + +K Sbjct: 73 RVQKS-LFGVNAIQGMDGSAHIHRKMLFLSLMTPPHQKRLAELMTEEWKAAVTRWEKAD- 130 Query: 178 QNARGSLTLDVQPSIFHYTIEASNLAL-FGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 236 + +F E + + L + +F+ ++ Sbjct: 131 -----------EVVLFEEAKEILCRVACYWAGVPLKETEVKERADDFIDMVDAFGA---- 175 Query: 237 LMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLK 296 W + E + + + + K A + +T L Sbjct: 176 -----VGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMAFHTQEDGSQLDS 230 Query: 297 AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ 356 ++E I N + ++ L+ + L +P ++ LR + Sbjct: 231 RMAAIELI--NVLRPIVA----ISYFLVFSALALHEHPKYKEWLRSGNSRER-------- 276 Query: 357 KATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAAL 416 ++E R YP G FL +V D V N GT V + LY + L Sbjct: 277 ---------EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRL 327 Query: 417 FPRPERYNPQRWLDIRGSGRNFHHVPFGFGM----RQCLGRRLAEAEMLLLLHHVLKHFL 472 + P+ + P+R+ + + F +P G G +C G + M L ++ Sbjct: 328 WDHPDEFRPERFAEREENL--FDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIE 385 Query: 473 VETLTQEDIKMVYSFILRPGTS 494 + + + YS P Sbjct: 386 YDVP---EQSLHYSLARMPSLP 404 >5KYO-A nrPDB Length = 430 Score = 104 bits (259), Expect = 8e-23, Method: Composition-based stats. Identities = 56/381 (14%), Positives = 118/381 (30%), Gaps = 41/381 (10%) Query: 133 NGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSI 192 NG W R L V+S +RF V ++ + + + + + + Sbjct: 80 NGGHWVALRSDLAETVMSD--FERFSNHTVLVPKETAGEAYRLIPLSLDPPEHRPFRSLL 137 Query: 193 FH----YTIEASNLALFGERLGLVGHSPSSASLNFLHAL--EVMFKSTVQLMFMPRSLSR 246 + + + L+ NF H ++ + ++++ +P Sbjct: 138 NENLGPKPLRPIEQVVTDLAVSLIEGFRPKGRCNFTHEFAEQLPVRIFMRIVDLPVEDLP 197 Query: 247 WISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE-----LSL 301 + + ++ + + R + ++ E L+ Sbjct: 198 KLKHLADQYTRPDGSIPLDDVTKQFREYLRPVIEARRIKPGEDMISRMINGEVGGRPLTD 257 Query: 302 EAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTE 361 + +++ G +DT L T LA++ +++ + + Sbjct: 258 IEAENICIQVLVGGLDTVVNMLGFTFSHLAKDHALRRAIAADP----------------- 300 Query: 362 LPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPE 421 L+ AL E R +PV R V D + + AG +V + + A P Sbjct: 301 -SLIDDALLEFFRRFPVVSS-AREVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPL 358 Query: 422 RYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDI 481 + R + H FG G C G LA EM ++L + ++D Sbjct: 359 EFRLGR--------KARQHSTFGKGSHTCPGAHLARMEMKVVLREWFARIPEFRI-EDDA 409 Query: 482 KMVYSFILRPGTSPLLTFRAI 502 + YS + P + + Sbjct: 410 PLRYSNGIVGSVKPFVLEWPV 430 >2QBO-A nrPDB Length = 421 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 43/279 (15%), Positives = 85/279 (30%), Gaps = 33/279 (11%) Query: 225 HALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQ 284 +A + + L +P + + F + + R Q Sbjct: 155 YAEPFPIRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSMTFAEAKEALYDYLIPIIEQRRQ 214 Query: 285 HYTGIVAELLLKAE-----LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQI 339 ++ + ++ + K L +DT L ++ LA++P+ +Q Sbjct: 215 KPGTDAISIVANGQVNGRPITSDEAKRMCGLLLVVGLDTVVNFLSFSMEFLAKSPEHRQE 274 Query: 340 LRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPA 399 L + + AA +E LR + + R+++SD + Sbjct: 275 LIERPER------------------IPAACEELLRRFS-LVADGRILTSDYEFHGVQLKK 315 Query: 400 GTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAE 459 G + + G + P + R + H FG G CLG+ LA E Sbjct: 316 GDQILLPQMLSGLDERENACPMHVDFSR--------QKVSHTTFGHGSHLCLGQHLARRE 367 Query: 460 MLLLLHHVLKHF-LVETLTQEDIKMVYSFILRPGTSPLL 497 +++ L L I+ + PL+ Sbjct: 368 IIVTLKEWLTRIPDFSIAPGAQIQHKSGIVSGVQALPLV 406 >2RCM-A nrPDB Length = 495 Score = 102 bits (255), Expect = 3e-22, Method: Composition-based stats. Identities = 82/489 (16%), Positives = 167/489 (34%), Gaps = 79/489 (16%) Query: 26 TRAARAPRTVLPFEAMPQHPGNRWLRLLQ-------IWREQGYEHLHLEMHQTFQELGPI 78 T A R LP +P GN L ++ + +QG E + + + Sbjct: 15 TVATRTGSKDLPIRNIP---GNYGLPIVGPIKDRWDYFYDQGAEEFFKSRIRKYNS--TV 69 Query: 79 FRYNL-------GGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFL 131 +R N+ P++V ++ + L VD + ++ ++ + G + Sbjct: 70 YRVNMPPGAFIAENPQVVALLDGKSFPVLFDVDKVEKKDLLTGTYMPSTELTGGYRILSY 129 Query: 132 LNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPS 191 L+ E + +L+ L + R P A + +L+K++ + + Sbjct: 130 LDPSEPKHEKLKNLLFFLLKSSRNRIFPEFQATYSELFDSLEKELSLKGKADFGGSSDGT 189 Query: 192 IFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPK 251 F++ A +G + A L V+F +L +S Sbjct: 190 AFNF----LARAFYGTN---PADTKLKADAPGLITKWVLF-----------NLHPLLSIG 231 Query: 252 VWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE---LSLEAIKANS 308 + + E F ++ YQ L + + E+L++A+ +S E N Sbjct: 232 LPRVIEEPLIHTFSLPPALVKSDYQRLY----EFFLESAGEILVEADKLGISREEATHN- 286 Query: 309 MELTAGSVDTTAFPLLMTLFELARNP-----------DVQQILRQESLAAAASIS-EHPQ 356 L A +T ++ P V L +E + S E Sbjct: 287 -LLFATCFNT------WGGMKIL-FPNMVKRIGRAGHQVHNRLAEEIRSVIKSNGGELTM 338 Query: 357 KATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNY----HIPAGTLVQVFLYSLGR 412 A ++ L ++ + E LR P DLV++++ + AG ++ + R Sbjct: 339 GAIEKMELTKSVVYECLRFEPPVTAQYGRAKKDLVIESHDAAFKVKAGEMLYGYQPLATR 398 Query: 413 NAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGM---------RQCLGRRLAEAEMLLL 463 + +F R + + P+R++ G + HV + G +QC G+ L Sbjct: 399 DPKIFDRADEFVPERFVGEEGE-KLLRHVLWSNGPETETPTVGNKQCAGKDFVVLVARLF 457 Query: 464 LHHVLKHFL 472 + + + + Sbjct: 458 VIEIFRRYD 466 >3AWQ-A nrPDB Length = 415 Score = 98.3 bits (243), Expect = 8e-21, Method: Composition-based stats. Identities = 27/132 (20%), Positives = 54/132 (40%), Gaps = 7/132 (5%) Query: 359 TTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFP 418 + ++E R YP + S D + P G V + LY +AA + Sbjct: 268 VQQPDYAELFVQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWA 327 Query: 419 RPERYNPQRWLDIRGSGRNFHHVPFGFGM----RQCLGRRLAEAEMLLLLHHVLKHFLVE 474 P+ + P+R+ +F+ +P G G +C G + A M + H+L + + Sbjct: 328 DPQEFRPERFRAWDED--SFNFIPQGGGDHYLGHRCPGEWIVLAIMKVA-AHLLVNAMRY 384 Query: 475 TLTQEDIKMVYS 486 + +D+ + ++ Sbjct: 385 DVPDQDLSIDFA 396 >4C9K-A nrPDB Length = 421 Score = 97.6 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 56/388 (14%), Positives = 113/388 (29%), Gaps = 53/388 (13%) Query: 134 GPEWRFNRLRLNPDV-------------LSPKAVQRFLPMVDAVARDFSQALKKKVLQNA 180 G W R L ++ + +A + + + + +K + + Sbjct: 62 GGHWIATRGTLIDEIYRSPERFSSRVIWVPREAGEAYDMVPTKLDPPEHTPYRKAIDKGL 121 Query: 181 RGSLTLDVQPSIFHYTIEASN------LALFGERLGLVGHSPSSASLNFLHALEVMFKST 234 + ++ I +E FG V + AL + Sbjct: 122 NLAEIRKLEDQIRTIAVEIIEGFADRGHCEFGSEFSTV------FPVRVFLALAGLPVED 175 Query: 235 VQLMFMPRSLSRWISPKVWKEHFEAWDCI-FQYGDNCIQKIYQELAFNRPQHYTGIVAEL 293 + + + S +E + + + + I + T I+ Sbjct: 176 ATKLGLLANEMTRPSGNTPEEQGRSLEAANKGFFEYVAPIIAARRGGSGTDLITRILNVE 235 Query: 294 LLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISE 353 + + + L G +DT L + L+R+P+ +R+E L Sbjct: 236 IDGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHPETVAEMRREPLKLQRG--- 292 Query: 354 HPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRN 413 ++E R + V R V SD+ + G L+ + G + Sbjct: 293 ---------------VEELFRRFAVV-SDARYVVSDMEFHGTMLKEGDLILLPTALHGLD 336 Query: 414 AALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLV 473 P + R R+ H F G +C G LA E+ ++L L Sbjct: 337 DRHHDDPMTVDLSR--------RDVTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPE 388 Query: 474 ETLTQEDIKMVYSFILRPGTSPLLTFRA 501 L + + +S I+ + L + Sbjct: 389 FRLKDRAVPIYHSGIVAAVENIPLEWEP 416 >3B98-A nrPDB Length = 475 Score = 89.5 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 44/199 (22%), Positives = 76/199 (38%), Gaps = 26/199 (13%) Query: 324 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 + L +P+ + +R+E ++ P+ + L ETLRL + Sbjct: 274 FWVMGYLLTHPEALRAVREEI---QGGKHLRLEERQKNTPVFDSVLWETLRL-TAAALIT 329 Query: 384 RVVSSDLVL-----QNYHIPAGTLVQVFLY-SLGRNAALFPRPERYNPQRWLD------- 430 R V+ D + Q YH+ G + VF + S + + +PE + R+L+ Sbjct: 330 RDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKK 389 Query: 431 ---IRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVE------TLTQEDI 481 G+ + VP+G C GR A + L+ +L F VE T+ D Sbjct: 390 DFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDP 449 Query: 482 KMVYSFILRPGTSPLLTFR 500 IL+P + +R Sbjct: 450 SRYGFGILQPAGDLEIRYR 468 >3DBM-A nrPDB Length = 473 Score = 84.8 bits (208), Expect = 7e-17, Method: Composition-based stats. Identities = 65/467 (13%), Positives = 153/467 (32%), Gaps = 56/467 (11%) Query: 37 PFEAMPQHPG-----NRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL-------G 84 P +P G RL + G + Q +Q +FR N+ Sbjct: 7 PLREIPGSYGIPFFQPIKDRLEYFYGTGGRDEYFRSRMQKYQS--TVFRANMPPGPFVSS 64 Query: 85 GPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRL 144 P+++ ++ + L V + + ++ + G + L+ E R +L+ Sbjct: 65 NPKVIVLLDAKSFPILFDVSKVEKKDLFTGTYMPSTKLTGGYRVLSYLDPSEPRHAQLKN 124 Query: 145 NPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLT-LDVQPSIFHYTIEASNLA 203 + + R +P + + + L+ ++ +N + + + Q + N Sbjct: 125 LLFFMLKNSSNRVIPQFETTYTELFEGLEAELAKNGKAAFNDVGEQAAFRFLGRAYFNSN 184 Query: 204 LFGERLGLVGHSPSSASLNF---LHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAW 260 +LG + S+ + F + + + L ++ + + ++ Sbjct: 185 PEETKLGTSAPTLISSWVLFNLAPTLDLGLPWFLQEPLLHTFRLPAFLIKSTYNKLYD-- 242 Query: 261 DCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTA 320 FQ + + ++L + + I+ A G Sbjct: 243 --YFQSVATPVMEQAEKLGVPKDEAVHNILF--------------AVCFNTFGGVKILFP 286 Query: 321 FPLLMTLFELARNPDVQQILRQESLAAAASISE--HPQKATTELPLLRAALKETLRLYPV 378 L N Q L +E A S + +A ++PL ++ + E+LR+ P Sbjct: 287 NTLKWIGLA-GENLHTQ--LAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEPP 343 Query: 379 GLFLERVVSSDLVLQNY----HIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS 434 S+ ++++ + G ++ + ++ +F RPE Y P R++ + Sbjct: 344 VPPQYGKAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDGEA 403 Query: 435 GRNFHHVPFGFGM---------RQCLGRRLAEAEMLLLLHHVLKHFL 472 +V + G +QC G+ L + + + + Sbjct: 404 LLK--YVWWSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYD 448 >2YJN-B nrPDB Length = 381 Score = 67.9 bits (164), Expect = 9e-12, Method: Composition-based stats. Identities = 23/129 (17%), Positives = 47/129 (36%), Gaps = 18/129 (13%) Query: 312 TAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKE 371 + TA ++ + ++ P + + + + AA + E Sbjct: 220 LFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAAAQR------------------TVAE 261 Query: 372 TLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDI 431 LRL+P R ++++ L + I G V V + + R+ +F P+R + R Sbjct: 262 VLRLHPALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDRPDAD 321 Query: 432 RGSGRNFHH 440 R + H Sbjct: 322 RALSAHRGH 330 >6F73-A nrPDB Length = 574 Score = 35.2 bits (79), Expect = 0.073, Method: Composition-based stats. Identities = 18/90 (20%), Positives = 30/90 (33%), Gaps = 7/90 (7%) Query: 2 ALRAKAEVCV-AAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLR----LLQIW 56 A R +C A W + R A T+ P G+ +L L W Sbjct: 468 AWRTGMLLCAPAGSWDWDASPEEMAARDRYAAETLQPMMDAATPGGSVYLNEANHLYANW 527 Query: 57 REQGYEHLHLEMHQTFQELGP--IFRYNLG 84 +E Y + + + ++ P +F G Sbjct: 528 KESFYGDNYARLLRVKKKYDPDSVFYVKTG 557 >4YXC-B nrPDB Length = 227 Score = 33.2 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 30/142 (21%), Positives = 47/142 (33%), Gaps = 11/142 (7%) Query: 270 CIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVD---TTAFPLLMT 326 + Y + + E K S E A + TT Sbjct: 68 TVNGQYALRVEHLINPILNSLNEEQPKNNPSDENTGALDDLWADALNEQKATTTKSAADA 127 Query: 327 LFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRL-YPVGLFLERV 385 +F+ DV ++ I + P K T EL R +KE LRL + L+ + Sbjct: 128 VFQQLGGGDVSGAMQD-----IDLIMDIPVKLTVELGRTRMTIKELLRLTQGSVVALDGL 182 Query: 386 VSS--DLVLQNYHIPAGTLVQV 405 D+++ Y I G +V V Sbjct: 183 AGEPLDILINGYLIAQGEVVVV 204 >3GFZ-A nrPDB Length = 413 Score = 33.2 bits (74), Expect = 0.26, Method: Composition-based stats. Identities = 27/169 (15%), Positives = 47/169 (27%), Gaps = 25/169 (14%) Query: 283 PQHYTGIVAELLLKAELSLEAIKANSMELTAG--------SVDTTAFPLLMTLFELARNP 334 P + L+ +A + + L G + L + R+ Sbjct: 21 PDRPPVDLDALVHRASSKNLPLGITGILLFNGLQFFQVLEGTEEALESLFSEIQSDPRHR 80 Query: 335 DVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQN 394 DV +++R S + AL+E LR Sbjct: 81 DVVELMRDYSAYRRFHGTGMRILDLRLFE-TDGALEEILRFSTF---------------G 124 Query: 395 YHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFH-HVP 442 P + L + + + PE P RW+ + SG H+P Sbjct: 125 VTEPVNDRMFRLLSAFIADGGRYCLPEPLQPSRWMMMPASGTAAPQHLP 173 >2XTZ-A nrPDB Length = 354 Score = 31.7 bits (70), Expect = 0.82, Method: Composition-based stats. Identities = 29/190 (15%), Positives = 57/190 (30%), Gaps = 22/190 (11%) Query: 139 FNRLRLNPDVLSPKAVQRFLPMVDAVARDF----SQALKKKVLQNARGSLTLDVQPSIFH 194 + R+R V + V R F + ++K + G V IF Sbjct: 159 YARVRTTGVVEIQFSPVGENKKSGEVYRLFDVGGQRNERRKWIHLFEG-----VTAVIFC 213 Query: 195 YTIEASNLALFGER-----------LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS 243 I + LF + V P +F+ L +++ +P + Sbjct: 214 AAISEYDQTLFEDEQKNRMMETKELFDWVLKQPCFEKTSFMLFLNKFDIFEKKVLDVPLN 273 Query: 244 LSRWISP-KVWKEHFEAWDCIFQYGDNCIQK-IYQELAFNRPQHYTGIVAELLLKAELSL 301 + W + + + +++ ++ YQ A +R I L +L Sbjct: 274 VCEWFRDYQPVSSGKQEIEHAYEFVKKKFEELYYQNTAPDRVDRVFKIYRTTALDQKLVK 333 Query: 302 EAIKANSMEL 311 + K L Sbjct: 334 KTFKLVDETL 343 >1R6B-X nrPDB Length = 758 Score = 31.3 bits (69), Expect = 0.93, Method: Composition-based stats. Identities = 16/70 (22%), Positives = 26/70 (37%), Gaps = 2/70 (2%) Query: 321 FPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL 380 + L L NP ++ L S+ A E P+L A+ +E R L Sbjct: 25 MTVEHLLLALLSNPSAREALEACSVDLVALRQELEAFIEQTTPVLPASEEE--RDTQPTL 82 Query: 381 FLERVVSSDL 390 +RV+ + Sbjct: 83 SFQRVLQRAV 92 >4YXB-D nrPDB Length = 80 Score = 30.5 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 15/55 (27%), Positives = 23/55 (41%), Gaps = 3/55 (5%) Query: 354 HPQKATTELPLLRAALKETLRL-YPVGLFLERVVSS--DLVLQNYHIPAGTLVQV 405 EL R +KE LRL + L+ + D+++ Y I G +V V Sbjct: 3 LDDLWADELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 57 >4N4R-A nrPDB Length = 786 Score = 29.0 bits (63), Expect = 4.4, Method: Composition-based stats. Identities = 33/233 (14%), Positives = 59/233 (25%), Gaps = 37/233 (15%) Query: 103 VDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVD 162 + HP W+ Y QH GV WRFN + + D Sbjct: 298 YEDDHPKEGDKHRWLFYWQH----SGVM---DQVWRFN--------------VDYTKVSD 336 Query: 163 AVA-RDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASL 221 + DF A ++ F T+ +F ++ + + Sbjct: 337 SSYFNDFDSKYGSSTDGYATQKFSVGYAVQNFDATVSTKQFQVFNDQNTSSYSAEPQLDV 396 Query: 222 NFLHALEVMFKST---------VQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQ 272 N+ H F + MP + + P + W + Sbjct: 397 NYYHNDLGPFDTRIYGQAVHFVNTKDNMPEATRVHLEPTINLPLSNRWGSLNTEAKLMAT 456 Query: 273 KIYQ------ELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTT 319 Q N V ++ + ++ + I M + A T Sbjct: 457 HYQQTNLDSYNSDPNNKNKLEDSVNRVMPQFKVDGKLIFERDMAMLAPGYTQT 509 >2C4R-L nrPDB Length = 517 Score = 28.6 bits (62), Expect = 6.4, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 28/91 (30%) Query: 283 PQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQ 342 + G L +A SLE + + + V +A L L ++ + + + Sbjct: 147 SRRIEGDDRTELKEALASLELPEGMGLIVRTAGVGKSAEALQWDLSFRLKHWEAIKKAAE 206 Query: 343 ESLAAAASISEHPQKATTELPLLRAALKETL 373 A E LR + E L Sbjct: 207 SRPAPFLIHQESNVIVRAFRDYLRQDIGEIL 237 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.124 0.321 Lambda K H 0.267 0.0380 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,784,484 Number of Sequences: 36641 Number of extensions: 650157 Number of successful extensions: 2931 Number of sequences better than 10.0: 179 Number of HSP's better than 10.0 without gapping: 276 Number of HSP's successfully gapped in prelim test: 69 Number of HSP's that attempted gapping in prelim test: 2083 Number of HSP's gapped (non-prelim): 368 length of query: 503 length of database: 10,336,785 effective HSP length: 101 effective length of query: 402 effective length of database: 6,636,044 effective search space: 2667689688 effective search space used: 2667689688 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (20.9 bits) S2: 61 (28.2 bits)