BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P18754 (421 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5TBK-I nrPDB 863 0.0 4NC4-A nrPDB 167 6e-42 5HQ2-K nrPDB 155 3e-38 5XGS-A nrPDB 75 6e-14 4X33-B nrPDB 43 2e-04 4D4O-A nrPDB 43 3e-04 6ELZ-p nrPDB 32 0.64 5T5I-A nrPDB 28 7.2 4HAC-B nrPDB 28 8.9 5W0A-A nrPDB 28 9.1 5XKU-A nrPDB 28 9.3 >5TBK-I nrPDB Length = 421 Score = 863 bits (2230), Expect = 0.0, Method: Compositional matrix adjust. Identities = 421/421 (100%), Positives = 421/421 (100%) Query: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60 Query: 61 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK Sbjct: 61 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120 Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180 Query: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV Sbjct: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240 Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS Sbjct: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 Query: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV Sbjct: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360 Query: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ Sbjct: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 Query: 421 S 421 S Sbjct: 421 S 421 >4NC4-A nrPDB Length = 377 Score = 167 bits (424), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 129/357 (36%), Positives = 185/357 (51%), Gaps = 32/357 (8%) Query: 36 LVLTLGQGDVGQLGLGENVMERKKPALVSIPE--DVVQAEAGGMHTVCLSKSG-QVYSFG 92 +V + G+G+ GQLG G+ +R P +S + +V G HTV S+SG +VYS+G Sbjct: 23 IVCSWGRGEDGQLGHGD-AEDRPSPTQLSALDGHQIVSVTCGADHTVAYSQSGMEVYSWG 81 Query: 93 CNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGV 152 D G LG S + +P K ++ Q++ GDSH A+T +G V WG R+ NG Sbjct: 82 WGDFGRLGHGNSSDLFTPLPIKALHGIRIKQIACGDSHCLAVTMEGEVQSWG--RNQNGQ 139 Query: 153 IGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPEL 210 +GL + + S+VP ++Q + + VA+G +H +T DGDLY G G G LG Sbjct: 140 LGLGD-TEDSLVPQKIQAFEGIRIKMVAAGAEHTAAVTEDGDLYGWGWGRYGNLG----- 193 Query: 211 FANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYH 270 +R R LVP+ V S G + CG T ++S+ G +Y +G S Y Sbjct: 194 LGDRTDR------LVPERVT-----STGGEKMSMVACGWRHTISVSYSGALYTYGWSKYG 242 Query: 271 QLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGE 330 QLG E IP L + NS S + SGG HT+ + S+GK Y G ++G++G+G Sbjct: 243 QLGHGDLEDHLIPHKLEALSNSFISQI--SGGFRHTMALTSDGKLYGWGWNKFGQVGVGN 300 Query: 331 GAEEKSIPTLISRLP---AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDED 384 ++ S P + R P V V+CG AVT+ VFAWG GTN QLG G+ D Sbjct: 301 NLDQCS-PVQV-RFPDDQKVVQVSCGWRHTLAVTERNNVFAWGRGTNGQLGIGESVD 355 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 100/364 (27%), Positives = 171/364 (46%), Gaps = 45/364 (12%) Query: 66 PEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ----EKV 121 P V+ AG H+V L V S+G ++G LG + E P +L ++ Sbjct: 2 PRKVLIISAGASHSVALLSGDIVCSWGRGEDGQLGHGDA----EDRPSPTQLSALDGHQI 57 Query: 122 VQVSAGDSHTAALTDDG-RVFLWGSFRDNNGVIG------LLEPMKKSMVPVQVQLDVPV 174 V V+ G HT A + G V+ WG + G +G L P+ P++ + + Sbjct: 58 VSVTCGADHTVAYSQSGMEVYSWG--WGDFGRLGHGNSSDLFTPL-----PIKALHGIRI 110 Query: 175 VKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSR 234 ++A G+ H + +T +G++ + G + GQLG E LVP+ K + Sbjct: 111 KQIACGDSHCLAVTMEGEVQSWGRNQNGQLGLGDT-----------EDSLVPQ----KIQ 155 Query: 235 GSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTK 294 G +R + GA T A++ +G +YG+G Y LG +P+ +TS Sbjct: 156 AFEG-IRIKMVAAGAEHTAAVTEDGDLYGWGWGRYGNLGLGDRTDRLVPERVTSTGGEKM 214 Query: 295 SWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPA--VSSVAC 352 S V + G HT+ + G Y+ G ++YG+LG G+ E+ IP + L +S ++ Sbjct: 215 SMV--ACGWRHTISVSYSGALYTYGWSKYGQLGHGD-LEDHLIPHKLEALSNSFISQISG 271 Query: 353 GASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412 G A+T DG+++ WG Q+G G + D SPV++ + +++ V+ VS G +HT+ Sbjct: 272 GFRHTMALTSDGKLYGWGWNKFGQVGVGNNLDQCSPVQV--RFPDDQKVVQVSCGWRHTL 329 Query: 413 LLVK 416 + + Sbjct: 330 AVTE 333 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 46/149 (30%), Positives = 73/149 (48%), Gaps = 7/149 (4%) Query: 27 HRSHSTEPGLVLTLGQGDVGQLGLGE---NVMERKKPALVSIPEDVVQAEAGGMHTVCLS 83 H + G + T G GQLG G+ +++ K AL + + Q G HT+ L+ Sbjct: 223 HTISVSYSGALYTYGWSKYGQLGHGDLEDHLIPHKLEALSN--SFISQISGGFRHTMALT 280 Query: 84 KSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLW 143 G++Y +G N G +G +++ V + +KVVQVS G HT A+T+ VF W Sbjct: 281 SDGKLYGWGWNKFGQVGVGNNLDQCSPVQVRFPDDQKVVQVSCGWRHTLAVTERNNVFAW 340 Query: 144 GSFRDNNGVIGLLEPMKKSMVPVQVQLDV 172 G R NG +G+ E + ++ + L V Sbjct: 341 G--RGTNGQLGIGESVDRNFPKIIEALSV 367 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 53/175 (30%), Positives = 79/175 (45%), Gaps = 8/175 (4%) Query: 248 GAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTV 307 GA + A+ V +G QLG E P L++ V + G HTV Sbjct: 11 GASHSVALLSGDIVCSWGRGEDGQLGHGDAEDRPSPTQLSALDGHQI--VSVTCGADHTV 68 Query: 308 CMDSEG-KAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV--SSVACGASVGYAVTKDG 364 G + YS G ++GRLG G + + P I L + +ACG S AVT +G Sbjct: 69 AYSQSGMEVYSWGWGDFGRLGHGN-SSDLFTPLPIKALHGIRIKQIACGDSHCLAVTMEG 127 Query: 365 RVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKE 419 V +WG N QLG G ED+ P ++ + E + V++G +HT + +D + Sbjct: 128 EVQSWGRNQNGQLGLGDTEDSLVPQKI--QAFEGIRIKMVAAGAEHTAAVTEDGD 180 >5HQ2-K nrPDB Length = 483 Score = 155 bits (392), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 126/463 (27%), Positives = 213/463 (46%), Gaps = 86/463 (18%) Query: 19 KSKKVKVSHRSH-------------STEPGLVLTLGQGDVGQLGLG--ENVMERKKPALV 63 ++KK+ +H SH S +P + G G + +LGLG E K+P L Sbjct: 18 RAKKMSKTHASHIINAQEDYKHMYLSVQPLDIFCWGTGSMCELGLGPLAKNKEVKRPRLN 77 Query: 64 S-IPED---VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTS--------------- 104 +P D ++ GGMHT+ L + V+S+GCND GALGRDTS Sbjct: 78 PFLPRDEAKIISFAVGGMHTLALDEESNVWSWGCNDVGALGRDTSNAKEQLKDMDADDSS 137 Query: 105 ------VEGSEMVPGKVELQ--------EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNN 150 + E P K+ + KVVQ++A D+ + AL +G V+ WG+FR N Sbjct: 138 DDEDGDLNELESTPAKIPRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAWGTFRCNE 197 Query: 151 GVIGLLE---PMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRV 207 G++G + ++K+ V +V++A G DH++ L +G ++ G G+Q QL Sbjct: 198 GILGFYQDKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFAWGNGQQNQL--- 254 Query: 208 PELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLS 267 GR+ +ER + K + + G R HV++ + G FA++ + + +GL+ Sbjct: 255 --------GRKVMERFRL-KTLDPRPFGLR-HVKYIAS--GENHCFALTKDNKLVSWGLN 302 Query: 268 NYHQLG-TPGTESCFI---PQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEY 323 + Q G + E + P+ L N + G+HH++ + +G YS GR + Sbjct: 303 QFGQCGVSEDVEDGALVTKPKRLALPDNVVIR--SIAAGEHHSLILSQDGDLYSCGRLDM 360 Query: 324 GRLGLGEG-------------AEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWG 370 +G+ + A +PT ++ +P SVA G+ AV ++G ++WG Sbjct: 361 FEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPKFKSVAAGSHHSVAVAQNGIAYSWG 420 Query: 371 MGTNYQLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412 G Y +G G ++D P + ++ ++ V GGQ +V Sbjct: 421 FGETYAVGLGPFEDDTEVPTRIKNTATQDHNIILVGCGGQFSV 463 >5XGS-A nrPDB Length = 427 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 103/382 (26%), Positives = 158/382 (41%), Gaps = 51/382 (13%) Query: 60 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALGRDTSVEGSEMVPGKVE 116 P + + + + A G T+ SK+ +V+ G N + LG + P V Sbjct: 69 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHGGGYEYVLEPSPVS 128 Query: 117 L------QEKVVQVSAGDSHTAALTDDGRVFLWG--SFRDNNGVIGLLEPMKKSMVPVQV 168 L + +V+QVS G +H+ LTD VF G S+ + E +S ++ Sbjct: 129 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRM 188 Query: 169 Q-LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227 Q D VV+VA G DH + LT G++Y+ G G GQ G + + G + L Sbjct: 189 QDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD-LAGVN 247 Query: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGT-PGTESCFIPQNL 286 + + + G A+S +G ++G+G S Y QL + + +P+ L Sbjct: 248 VIQVATYGD--------------CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCL 293 Query: 287 TSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL-- 344 F K GG V ++ EG + G YG LG G E ++P +I Sbjct: 294 -HFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLF 348 Query: 345 --------PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VEMMGK 394 VS + CG S A+T G +F WG LG G+ ED + P V M G+ Sbjct: 349 GLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGE 408 Query: 395 QLENRVVLSVSSGGQHTVLLVK 416 ++ V+ G H V L K Sbjct: 409 PVD------VACGVDHMVTLAK 424 >4X33-B nrPDB Length = 333 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 51/195 (26%), Positives = 82/195 (42%), Gaps = 34/195 (17%) Query: 88 VYSFGCNDEG--ALGRDTSVEGSEM-VPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 144 VY+FG N + LG D ++ + VPG + V +++ G +H+ LT+DG + G Sbjct: 4 VYAFGSNGQRQLGLGHDEDMDTPQRSVPG--DDGAIVRKIACGGNHSVMLTNDGNLV--G 59 Query: 145 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 204 + G + + +++ V++ PVV VA G D V++ ADG ++ G Sbjct: 60 CGDNRRGELDSAQALRQVHDWRPVEVPAPVVDVACGWDTTVIVDADGRVWQRG------- 112 Query: 205 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 264 GG + VP L S R A G + F + VYG+ Sbjct: 113 ----------GGCYEFTQQHVP----LNSNDER------IAVYGCFQNFVVVQGTRVYGW 152 Query: 265 GLSNYHQLGTPGTES 279 G + QL P + S Sbjct: 153 GSNTKCQLQEPKSRS 167 Score = 34.3 bits (77), Expect = 0.093, Method: Compositional matrix adjust. Identities = 22/74 (29%), Positives = 37/74 (50%), Gaps = 10/74 (13%) Query: 142 LWGSFRDNNGVIGLLEPMKK---SMVPVQVQLDVPVVKVASGNDHLVMLTADG------- 191 +W S N + +E + S + Q +LD P+V VA+G++H ++ TA+ Sbjct: 228 MWTSIHLWNARLNTVESFGRGTHSQLFPQERLDFPIVGVATGSEHGILTTANQEGKSHCY 287 Query: 192 DLYTLGCGEQGQLG 205 ++Y G GE G G Sbjct: 288 NVYCWGWGEHGNCG 301 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 34/110 (30%), Positives = 48/110 (43%), Gaps = 9/110 (8%) Query: 37 VLTLGQGDVGQLGLGENVMERKKPALVSIPED----VVQAEAGGMHTVCLSKSGQVYSFG 92 V G QLGLG + E S+P D V + GG H+V L+ G + G Sbjct: 4 VYAFGSNGQRQLGLGHD--EDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCG 61 Query: 93 CNDEGALGRDTSV-EGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVF 141 N G L ++ + + P VE+ VV V+ G T + DGRV+ Sbjct: 62 DNRRGELDSAQALRQVHDWRP--VEVPAPVVDVACGWDTTVIVDADGRVW 109 Score = 32.7 bits (73), Expect = 0.31, Method: Compositional matrix adjust. Identities = 18/52 (34%), Positives = 28/52 (53%), Gaps = 1/52 (1%) Query: 366 VFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417 V+A+G QLG G DED +P + + +V ++ GG H+V+L D Sbjct: 4 VYAFGSNGQRQLGLGHDEDMDTPQRSVPGD-DGAIVRKIACGGNHSVMLTND 54 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 29/112 (25%), Positives = 41/112 (36%), Gaps = 1/112 (0%) Query: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320 VY FG + QLG E PQ + + G +H+V + ++G G Sbjct: 4 VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIV-RKIACGGNHSVMLTNDGNLVGCGD 62 Query: 321 AEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMG 372 G L + + + V VACG V DGRV+ G G Sbjct: 63 NRRGELDSAQALRQVHDWRPVEVPAPVVDVACGWDTTVIVDADGRVWQRGGG 114 >4D4O-A nrPDB Length = 427 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 52/195 (26%), Positives = 82/195 (42%), Gaps = 34/195 (17%) Query: 88 VYSFGCNDEG--ALGRDTSVEGSEM-VPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWG 144 VY+FG N + LG D ++ + VPG + V +++ G +H+ LT+DG + G Sbjct: 6 VYAFGSNGQRQLGLGHDEDMDTPQRSVPG--DDGAIVRKIACGGNHSVMLTNDGNLVGCG 63 Query: 145 SFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQL 204 R G + + +++ V++ PVV VA G D V++ ADG ++ G Sbjct: 64 DNR--RGELDSAQALRQVHDWRPVEVPAPVVDVACGWDTTVIVDADGRVWQRG------- 114 Query: 205 GRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGF 264 GG + VP L S R A G + F + VYG+ Sbjct: 115 ----------GGCYEFTQQHVP----LNSNDER------IAVYGCFQNFVVVQGTRVYGW 154 Query: 265 GLSNYHQLGTPGTES 279 G + QL P + S Sbjct: 155 GSNTKCQLQEPKSRS 169 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 22/74 (29%), Positives = 37/74 (50%), Gaps = 10/74 (13%) Query: 142 LWGSFRDNNGVIGLLEPMKK---SMVPVQVQLDVPVVKVASGNDHLVMLTADG------- 191 +W S N + +E + S + Q +LD P+V VA+G++H ++ TA+ Sbjct: 230 MWTSIHLWNARLNTVESFGRGTHSQLFPQERLDFPIVGVATGSEHGILTTANQEGKSHCY 289 Query: 192 DLYTLGCGEQGQLG 205 ++Y G GE G G Sbjct: 290 NVYCWGWGEHGNCG 303 Score = 33.5 bits (75), Expect = 0.16, Method: Compositional matrix adjust. Identities = 34/110 (30%), Positives = 48/110 (43%), Gaps = 9/110 (8%) Query: 37 VLTLGQGDVGQLGLGENVMERKKPALVSIPED----VVQAEAGGMHTVCLSKSGQVYSFG 92 V G QLGLG + E S+P D V + GG H+V L+ G + G Sbjct: 6 VYAFGSNGQRQLGLGHD--EDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCG 63 Query: 93 CNDEGALGRDTSV-EGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVF 141 N G L ++ + + P VE+ VV V+ G T + DGRV+ Sbjct: 64 DNRRGELDSAQALRQVHDWRP--VEVPAPVVDVACGWDTTVIVDADGRVW 111 Score = 33.1 bits (74), Expect = 0.22, Method: Compositional matrix adjust. Identities = 18/52 (34%), Positives = 28/52 (53%), Gaps = 1/52 (1%) Query: 366 VFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417 V+A+G QLG G DED +P + + +V ++ GG H+V+L D Sbjct: 6 VYAFGSNGQRQLGLGHDEDMDTPQRSVPGD-DGAIVRKIACGGNHSVMLTND 56 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 30/112 (26%), Positives = 41/112 (36%), Gaps = 1/112 (0%) Query: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320 VY FG + QLG E PQ + GG +H+V + ++G G Sbjct: 6 VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGG-NHSVMLTNDGNLVGCGD 64 Query: 321 AEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMG 372 G L + + + V VACG V DGRV+ G G Sbjct: 65 NRRGELDSAQALRQVHDWRPVEVPAPVVDVACGWDTTVIVDADGRVWQRGGG 116 Score = 28.1 bits (61), Expect = 7.8, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 46/109 (42%), Gaps = 15/109 (13%) Query: 316 YSLGRAEYGRLGLGEGAE----EKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGM 371 Y+ G +LGLG + ++S+P + V +ACG + +T DG + G Sbjct: 7 YAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAI--VRKIACGGNHSVMLTNDGNLVGCGD 64 Query: 372 GTNYQLGTGQ---DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKD 417 +L + Q W PVE+ V+ V+ G TV++ D Sbjct: 65 NRRGELDSAQALRQVHDWRPVEVPAP------VVDVACGWDTTVIVDAD 107 >6ELZ-p nrPDB Length = 460 Score = 31.6 bits (70), Expect = 0.64, Method: Compositional matrix adjust. Identities = 26/96 (27%), Positives = 40/96 (41%), Gaps = 29/96 (30%) Query: 291 NSTKSWVGFSGGQHHTV---------CMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLI 341 +ST + VG+S Q HT+ C+D+ +YSL I Sbjct: 296 DSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLS--------------------I 335 Query: 342 SRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQL 377 ++L ++ +ACG+S + D RV A T QL Sbjct: 336 AQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQL 371 >5T5I-A nrPDB Length = 569 Score = 28.1 bits (61), Expect = 7.2, Method: Compositional matrix adjust. Identities = 18/44 (40%), Positives = 20/44 (45%) Query: 346 AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 389 A S AC G V KDG V A G Y + T DE +S V Sbjct: 489 AFSRAACVLKDGEIVVKDGEVVASPHGRTYWVDTQVDESIYSEV 532 >4HAC-B nrPDB Length = 321 Score = 27.7 bits (60), Expect = 8.9, Method: Compositional matrix adjust. Identities = 31/103 (30%), Positives = 45/103 (43%), Gaps = 16/103 (15%) Query: 76 GMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALT 135 G H V S G++Y F G V G + VEL+ + V+ DS T + Sbjct: 18 GSHMVSCSAPGKIYLF--------GEHAVVYGETAIACAVELRTR-VRAELNDSITIQ-S 67 Query: 136 DDGRVFLWGSFRDNNGVIGLLEPMKKSM----VPVQVQLDVPV 174 GR L F + V ++E M+KS+ V + V D+PV Sbjct: 68 QIGRTGL--DFEKHPYVSAVIEKMRKSIPINGVFLTVDSDIPV 108 >5W0A-A nrPDB Length = 373 Score = 27.7 bits (60), Expect = 9.1, Method: Compositional matrix adjust. Identities = 16/32 (50%), Positives = 19/32 (59%), Gaps = 1/32 (3%) Query: 187 LTADGDLYTLGCGEQGQLGRVPELFANRGGRQ 218 L+ D DL TL CGE G L + E+ AN G Q Sbjct: 128 LSFDVDLSTLPCGENGAL-YLSEMAANGGANQ 158 >5XKU-A nrPDB Length = 328 Score = 27.7 bits (60), Expect = 9.3, Method: Compositional matrix adjust. Identities = 15/43 (34%), Positives = 21/43 (48%) Query: 277 TESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLG 319 T++ PQ S+KN+ KS G HH+V + K Y G Sbjct: 148 TDNAAFPQMTKSYKNTRKSPALIVWGIHHSVSTAEQTKLYGSG 190 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5TBK-I nrPDB 590 e-169 5HQ2-K nrPDB 435 e-122 4NC4-A nrPDB 390 e-109 5XGS-A nrPDB 371 e-103 4D4O-A nrPDB 181 5e-46 4X33-B nrPDB 175 4e-44 Sequences not found previously or not previously below threshold: 5Y7Y-B nrPDB 34 0.17 3W0L-B nrPDB 30 2.3 5FVM-C nrPDB 28 8.8 CONVERGED! >5TBK-I nrPDB Length = 421 Score = 590 bits (1520), Expect = e-169, Method: Composition-based stats. Identities = 421/421 (100%), Positives = 421/421 (100%) Query: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60 Query: 61 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK Sbjct: 61 ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK 120 Query: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG Sbjct: 121 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG 180 Query: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV Sbjct: 181 NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV 240 Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS Sbjct: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 Query: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV Sbjct: 301 GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360 Query: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ Sbjct: 361 TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ 420 Query: 421 S 421 S Sbjct: 421 S 421 >5HQ2-K nrPDB Length = 483 Score = 435 bits (1118), Expect = e-122, Method: Composition-based stats. Identities = 127/469 (27%), Positives = 213/469 (45%), Gaps = 86/469 (18%) Query: 14 ADAIPKSKKVKVSHRSH-------------STEPGLVLTLGQGDVGQLGLG--ENVMERK 58 A ++KK+ +H SH S +P + G G + +LGLG E K Sbjct: 13 ASGAHRAKKMSKTHASHIINAQEDYKHMYLSVQPLDIFCWGTGSMCELGLGPLAKNKEVK 72 Query: 59 KPALVS-IPED---VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTS---------- 104 +P L +P D ++ GGMHT+ L + V+S+GCND GALGRDTS Sbjct: 73 RPRLNPFLPRDEAKIISFAVGGMHTLALDEESNVWSWGCNDVGALGRDTSNAKEQLKDMD 132 Query: 105 -----------VEGSEMVPGKVEL--------QEKVVQVSAGDSHTAALTDDGRVFLWGS 145 + E P K+ KVVQ++A D+ + AL +G V+ WG+ Sbjct: 133 ADDSSDDEDGDLNELESTPAKIPRESFPPLAEGHKVVQLAATDNMSCALFSNGEVYAWGT 192 Query: 146 FRDNNGVIGLLE---PMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQG 202 FR N G++G + ++K+ V +V++A G DH++ L +G ++ G G+Q Sbjct: 193 FRCNEGILGFYQDKIKIQKTPWKVPTFSKYNIVQLAPGKDHILFLDEEGMVFAWGNGQQN 252 Query: 203 QLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVY 262 QLG R+ +ER + K + + G R HV++ + G FA++ + + Sbjct: 253 QLG-----------RKVMERFRL-KTLDPRPFGLR-HVKYIAS--GENHCFALTKDNKLV 297 Query: 263 GFGLSNYHQLG-TPGTESCFI---PQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSL 318 +GL+ + Q G + E + P+ L N + G+HH++ + +G YS Sbjct: 298 SWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIR--SIAAGEHHSLILSQDGDLYSC 355 Query: 319 GRAEYGRLGLGEG-------------AEEKSIPTLISRLPAVSSVACGASVGYAVTKDGR 365 GR + +G+ + A +PT ++ +P SVA G+ AV ++G Sbjct: 356 GRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPKFKSVAAGSHHSVAVAQNGI 415 Query: 366 VFAWGMGTNYQLGTGQ-DEDAWSPVEMMGKQLENRVVLSVSSGGQHTVL 413 ++WG G Y +G G ++D P + ++ ++ V GGQ +V Sbjct: 416 AYSWGFGETYAVGLGPFEDDTEVPTRIKNTATQDHNIILVGCGGQFSVS 464 Score = 108 bits (269), Expect = 5e-24, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 120/308 (38%), Gaps = 31/308 (10%) Query: 139 RVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL----DVPVVKVASGNDHLVMLTADGDLY 194 +F WG+ +G L K+ P + ++ A G H + L + +++ Sbjct: 48 DIFCWGTGSMCELGLGPLAKNKEVKRPRLNPFLPRDEAKIISFAVGGMHTLALDEESNVW 107 Query: 195 TLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR--------------GHV 240 + GC + G LGR + + + L S GH Sbjct: 108 SWGCNDVGALGRDTSNAKEQLKDMDADDSSDDEDGDLNELESTPAKIPRESFPPLAEGHK 167 Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGL--SNYHQLG--TPGTESCFIPQNLTSFKNSTKSW 296 Q A A+ G VY +G N LG + P + +F Sbjct: 168 VVQLAATDNMSC-ALFSNGEVYAWGTFRCNEGILGFYQDKIKIQKTPWKVPTFSKYNIVQ 226 Query: 297 VGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR---LPAVSSVACG 353 + G+ H + +D EG ++ G + +LG + E + TL R L V +A G Sbjct: 227 LAP--GKDHILFLDEEGMVFAWGNGQQNQLGR-KVMERFRLKTLDPRPFGLRHVKYIASG 283 Query: 354 ASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQ--LENRVVLSVSSGGQHT 411 + +A+TKD ++ +WG+ Q G +D + + V + +N V+ S+++G H+ Sbjct: 284 ENHCFALTKDNKLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHS 343 Query: 412 VLLVKDKE 419 ++L +D + Sbjct: 344 LILSQDGD 351 >4NC4-A nrPDB Length = 377 Score = 390 bits (1001), Expect = e-109, Method: Composition-based stats. Identities = 128/378 (33%), Positives = 187/378 (49%), Gaps = 28/378 (7%) Query: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPE--DVVQAEAGGMHTVCLS 83 SH +V + G+G+ GQLG G+ +R P +S + +V G HTV S Sbjct: 13 SHSVALLSGDIVCSWGRGEDGQLGHGD-AEDRPSPTQLSALDGHQIVSVTCGADHTVAYS 71 Query: 84 KSG-QVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFL 142 +SG +VYS+G D G LG S + +P K ++ Q++ GDSH A+T +G V Sbjct: 72 QSGMEVYSWGWGDFGRLGHGNSSDLFTPLPIKALHGIRIKQIACGDSHCLAVTMEGEVQS 131 Query: 143 WGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGE 200 WG R+ NG +GL + + S+VP ++Q + + VA+G +H +T DGDLY G G Sbjct: 132 WG--RNQNGQLGLGD-TEDSLVPQKIQAFEGIRIKMVAAGAEHTAAVTEDGDLYGWGWGR 188 Query: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 260 G LG +R R LVP+ V S G + CG T ++S+ G Sbjct: 189 YGNLG-----LGDRTDR------LVPERVT-----STGGEKMSMVACGWRHTISVSYSGA 232 Query: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320 +Y +G S Y QLG E IP L + NS S + SGG HT+ + S+GK Y G Sbjct: 233 LYTYGWSKYGQLGHGDLEDHLIPHKLEALSNSFISQI--SGGFRHTMALTSDGKLYGWGW 290 Query: 321 AEYGRLGLGEGAEEK-SIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT 379 ++G++G+G ++ + V V+CG AVT+ VFAWG GTN QLG Sbjct: 291 NKFGQVGVGNNLDQCSPVQVRFPDDQKVVQVSCGWRHTLAVTERNNVFAWGRGTNGQLGI 350 Query: 380 GQDEDAWSPVEMMGKQLE 397 G+ D P + ++ Sbjct: 351 GESVDRNFPKIIEALSVD 368 Score = 138 bits (347), Expect = 5e-33, Method: Composition-based stats. Identities = 62/251 (24%), Positives = 97/251 (38%), Gaps = 24/251 (9%) Query: 171 DVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVM 230 V+ +++G H V L + + + G GE GQLG + Sbjct: 2 PRKVLIISAGASHSVALLSGDIVCSWGRGEDGQLGHGDAEDRPSPTQL------------ 49 Query: 231 LKSRGSRGHVRFQDAFCGAYFTFAISHEG-HVYGFGLSNYHQLGTPGTESCFIPQNLTSF 289 + + CGA T A S G VY +G ++ +LG + F P + + Sbjct: 50 ----SALDGHQIVSVTCGADHTVAYSQSGMEVYSWGWGDFGRLGHGNSSDLFTPLPIKAL 105 Query: 290 KNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRL--PAV 347 + G H + + EG+ S GR + G+LGLG E+ +P I + Sbjct: 106 HGIRIKQIAC--GDSHCLAVTMEGEVQSWGRNQNGQLGLG-DTEDSLVPQKIQAFEGIRI 162 Query: 348 SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSG 407 VA GA AVT+DG ++ WG G LG G D P + + V+ G Sbjct: 163 KMVAAGAEHTAAVTEDGDLYGWGWGRYGNLGLGDRTDRLVPERV--TSTGGEKMSMVACG 220 Query: 408 GQHTVLLVKDK 418 +HT+ + Sbjct: 221 WRHTISVSYSG 231 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 51/181 (28%), Positives = 79/181 (43%), Gaps = 6/181 (3%) Query: 241 RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS 300 + GA + A+ V +G QLG E P L++ V + Sbjct: 4 KVLIISAGASHSVALLSGDIVCSWGRGEDGQLGHGDAEDRPSPTQLSALDGHQI--VSVT 61 Query: 301 GGQHHTVCMDSEG-KAYSLGRAEYGRLGLGEGAEE-KSIPTLISRLPAVSSVACGASVGY 358 G HTV G + YS G ++GRLG G ++ +P + +ACG S Sbjct: 62 CGADHTVAYSQSGMEVYSWGWGDFGRLGHGNSSDLFTPLPIKALHGIRIKQIACGDSHCL 121 Query: 359 AVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDK 418 AVT +G V +WG N QLG G ED+ P ++ + E + V++G +HT + +D Sbjct: 122 AVTMEGEVQSWGRNQNGQLGLGDTEDSLVPQKI--QAFEGIRIKMVAAGAEHTAAVTEDG 179 Query: 419 E 419 + Sbjct: 180 D 180 >5XGS-A nrPDB Length = 427 Score = 371 bits (951), Expect = e-103, Method: Composition-based stats. Identities = 103/385 (26%), Positives = 159/385 (41%), Gaps = 51/385 (13%) Query: 57 RKKPALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALGRDTSVEGSEMVPG 113 + P + + + + A G T+ SK+ +V+ G N + LG + P Sbjct: 66 QPVPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHGGGYEYVLEPS 125 Query: 114 KVEL------QEKVVQVSAGDSHTAALTDDGRVFLWG--SFRDNNGVIGLLEPMKKSMVP 165 V L + +V+QVS G +H+ LTD VF G S+ + E +S Sbjct: 126 PVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV 185 Query: 166 VQVQ-LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLL 224 ++Q D VV+VA G DH + LT G++Y+ G G GQ G + + G + L Sbjct: 186 HRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD-LA 244 Query: 225 VPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGT-PGTESCFIP 283 + + + G A+S +G ++G+G S Y QL + + +P Sbjct: 245 GVNVIQVATYGD--------------CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVP 290 Query: 284 QNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISR 343 + L F K GG V ++ EG + G YG LG G E ++P +I Sbjct: 291 RCL-HFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPEMIPP 345 Query: 344 L----------PAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VEM 391 VS + CG S A+T G +F WG LG G+ ED + P V M Sbjct: 346 TLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM 405 Query: 392 MGKQLENRVVLSVSSGGQHTVLLVK 416 G+ ++ V+ G H V L K Sbjct: 406 PGEPVD------VACGVDHMVTLAK 424 Score = 75.6 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 48/208 (23%), Positives = 76/208 (36%), Gaps = 20/208 (9%) Query: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP---EDVVQAEAGGMHTVCLS 83 H T+ G V + G G GQ GLG + P + +V+Q G + +S Sbjct: 204 HSLFLTDKGEVYSCGWGADGQTGLGHYNI-TSSPTKLGGDLAGVNVIQVATYGDCCLAVS 262 Query: 84 KSGQVYSFGCNDEGALGRDTSVEGS-EMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFL 142 G ++ +G ++ L T KV Q + G + A L +G VF+ Sbjct: 263 ADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFV 322 Query: 143 WGSFRDNNGVIGLLEPMKKSMVPV---QVQLD-------VPVVKVASGNDHLVMLTADGD 192 WG G++G + +S VP + V ++ G H LT G+ Sbjct: 323 WGY-----GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGE 377 Query: 193 LYTLGCGEQGQLGRVPELFANRGGRQGL 220 L+ G +G LG R + Sbjct: 378 LFVWGKNIRGCLGIGRLEDQYFPWRVTM 405 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 45/233 (19%), Positives = 70/233 (30%), Gaps = 53/233 (22%) Query: 192 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYF 251 ++ G G LG VP G + + + A CG F Sbjct: 29 RVFVWGFSFSGALG-VPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGF 87 Query: 252 TFAISHE---GHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVC 308 T S V+G GL+ S +GF GG Sbjct: 88 TLLSSKTADVTKVWGMGLNK-------------------------DSQLGFHGG------ 116 Query: 309 MDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFA 368 G Y L S+P + V V+CG + +T VF+ Sbjct: 117 ----GYEYVL------------EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFS 160 Query: 369 WGMGTNYQLGTGQDEDA-WSPVEMMGKQLE-NRVVLSVSSGGQHTVLLVKDKE 419 G + Q G E+ +S + + + + V+ V+ G H++ L E Sbjct: 161 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGE 213 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 1/60 (1%) Query: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKS 85 SH + T G + G+ G LG+G + ++ P V++P + V G H V L+KS Sbjct: 367 SHFAALTNKGELFVWGKNIRGCLGIG-RLEDQYFPWRVTMPGEPVDVACGVDHMVTLAKS 425 >4D4O-A nrPDB Length = 427 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 70/331 (21%), Positives = 117/331 (35%), Gaps = 73/331 (22%) Query: 88 VYSFGCNDEGALG--RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGS 145 VY+FG N + LG D ++ + + V +++ G +H+ LT+DG + G Sbjct: 6 VYAFGSNGQRQLGLGHDEDMDTPQRS-VPGDDGAIVRKIACGGNHSVMLTNDGNLV--GC 62 Query: 146 FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205 + G + + +++ V++ PVV VA G D V++ ADG ++ G Sbjct: 63 GDNRRGELDSAQALRQVHDWRPVEVPAPVVDVACGWDTTVIVDADGRVWQRG-------- 114 Query: 206 RVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFG 265 GG + VP L S R A G + F + VYG+G Sbjct: 115 ---------GGCYEFTQQHVP----LNSNDER------IAVYGCFQNFVVVQGTRVYGWG 155 Query: 266 LSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGK-AYSLGRAEYG 324 + QL P + S P + + + + + G+ V +D G+ ++ GR G Sbjct: 156 SNTKCQLQEPKSRSLKEP--VLVYDTGSVAVDYVAMGKDFMVIVDEGGRIVHASGRLPTG 213 Query: 325 ------------------------------RLGLGEGAEEKSIPTLISRLPAVSSVACGA 354 G G + P P + VA G+ Sbjct: 214 FELKQQQKRHNLVVLCMWTSIHLWNARLNTVESFGRGTHSQLFPQERLDFP-IVGVATGS 272 Query: 355 SVGYAVTKDG-------RVFAWGMGTNYQLG 378 G T + V+ WG G + G Sbjct: 273 EHGILTTANQEGKSHCYNVYCWGWGEHGNCG 303 Score = 58.3 bits (139), Expect = 7e-09, Method: Composition-based stats. Identities = 40/201 (19%), Positives = 58/201 (28%), Gaps = 48/201 (23%) Query: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320 VY FG + QLG E PQ + GG +H+V + ++G G Sbjct: 6 VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGG-NHSVMLTNDGNLVGCGD 64 Query: 321 AEYGRLGLGEGAEEKS--IPTLISRLPAVSSVACGASVGYAVTKDGR------------- 365 G L + + P + V VACG V DGR Sbjct: 65 NRRGELDSAQALRQVHDWRPVEVP--APVVDVACGWDTTVIVDADGRVWQRGGGCYEFTQ 122 Query: 366 ----------------------------VFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLE 397 V+ WG T QL + PV + Sbjct: 123 QHVPLNSNDERIAVYGCFQNFVVVQGTRVYGWGSNTKCQLQEPKSRSLKEPVLVYDTG-- 180 Query: 398 NRVVLSVSSGGQHTVLLVKDK 418 + V V+ G V++ + Sbjct: 181 SVAVDYVAMGKDFMVIVDEGG 201 Score = 57.9 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 51/300 (17%), Positives = 86/300 (28%), Gaps = 48/300 (16%) Query: 9 RRSPPAD--AIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP 66 +RS P D AI + +H T G ++ G G+L + + + V +P Sbjct: 29 QRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDNRRGELDSAQALRQVHDWRPVEVP 88 Query: 67 EDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKV-ELQEKVVQVS 125 VV G TV + G+V+ R + E++ Sbjct: 89 APVVDVACGWDTTVIVDADGRVWQ----------RGGGCYEFTQQHVPLNSNDERIAVYG 138 Query: 126 AGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLV 185 + + RV+ WGS +K+ V V V V VA G D +V Sbjct: 139 CFQN--FVVVQGTRVYGWGSNTKCQLQEPKSRSLKE-PVLVYDTGSVAVDYVAMGKDFMV 195 Query: 186 MLTADGD-LYTLGCGEQG---------------------QLGRVPELFANRGGRQGLERL 223 ++ G ++ G G L GR +L Sbjct: 196 IVDEGGRIVHASGRLPTGFELKQQQKRHNLVVLCMWTSIHLWNARLNTVESFGRGTHSQL 255 Query: 224 LVPKCVMLK----SRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279 + + + GS + G + + Y +G + G Sbjct: 256 FPQERLDFPIVGVATGSEHGILTTANQEGKSHCYNV------YCWGWGEHGNCGPQKGSQ 309 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 3/55 (5%) Query: 366 VFAWGMGTNYQLGTGQDEDAWSPVE-MMGKQLENRVVLSVSSGGQHTVLLVKDKE 419 V+A+G QLG G DED +P + G + +V ++ GG H+V+L D Sbjct: 6 VYAFGSNGQRQLGLGHDEDMDTPQRSVPGD--DGAIVRKIACGGNHSVMLTNDGN 58 >4X33-B nrPDB Length = 333 Score = 175 bits (443), Expect = 4e-44, Method: Composition-based stats. Identities = 70/331 (21%), Positives = 117/331 (35%), Gaps = 73/331 (22%) Query: 88 VYSFGCNDEGALG--RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGS 145 VY+FG N + LG D ++ + + V +++ G +H+ LT+DG + G Sbjct: 4 VYAFGSNGQRQLGLGHDEDMDTPQRS-VPGDDGAIVRKIACGGNHSVMLTNDGNLV--GC 60 Query: 146 FRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205 + G + + +++ V++ PVV VA G D V++ ADG ++ G Sbjct: 61 GDNRRGELDSAQALRQVHDWRPVEVPAPVVDVACGWDTTVIVDADGRVWQRG-------- 112 Query: 206 RVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFG 265 GG + VP L S R A G + F + VYG+G Sbjct: 113 ---------GGCYEFTQQHVP----LNSNDER------IAVYGCFQNFVVVQGTRVYGWG 153 Query: 266 LSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGK-AYSLGRAEYG 324 + QL P + S P + + + + + G+ V +D G+ ++ GR G Sbjct: 154 SNTKCQLQEPKSRSLKEP--VLVYDTGSVAVDYVAMGKDFMVIVDEGGRIVHASGRLPTG 211 Query: 325 ------------------------------RLGLGEGAEEKSIPTLISRLPAVSSVACGA 354 G G + P P + VA G+ Sbjct: 212 FELKQQQKRHNLVVLCMWTSIHLWNARLNTVESFGRGTHSQLFPQERLDFP-IVGVATGS 270 Query: 355 SVGYAVTKDG-------RVFAWGMGTNYQLG 378 G T + V+ WG G + G Sbjct: 271 EHGILTTANQEGKSHCYNVYCWGWGEHGNCG 301 Score = 56.0 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 40/201 (19%), Positives = 58/201 (28%), Gaps = 48/201 (23%) Query: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320 VY FG + QLG E PQ + GG +H+V + ++G G Sbjct: 4 VYAFGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGG-NHSVMLTNDGNLVGCGD 62 Query: 321 AEYGRLGLGEGAEEKS--IPTLISRLPAVSSVACGASVGYAVTKDGR------------- 365 G L + + P + V VACG V DGR Sbjct: 63 NRRGELDSAQALRQVHDWRPVEVP--APVVDVACGWDTTVIVDADGRVWQRGGGCYEFTQ 120 Query: 366 ----------------------------VFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLE 397 V+ WG T QL + PV + Sbjct: 121 QHVPLNSNDERIAVYGCFQNFVVVQGTRVYGWGSNTKCQLQEPKSRSLKEPVLVYDTG-- 178 Query: 398 NRVVLSVSSGGQHTVLLVKDK 418 + V V+ G V++ + Sbjct: 179 SVAVDYVAMGKDFMVIVDEGG 199 Score = 55.2 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 51/300 (17%), Positives = 86/300 (28%), Gaps = 48/300 (16%) Query: 9 RRSPPAD--AIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIP 66 +RS P D AI + +H T G ++ G G+L + + + V +P Sbjct: 27 QRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDNRRGELDSAQALRQVHDWRPVEVP 86 Query: 67 EDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKV-ELQEKVVQVS 125 VV G TV + G+V+ R + E++ Sbjct: 87 APVVDVACGWDTTVIVDADGRVWQ----------RGGGCYEFTQQHVPLNSNDERIAVYG 136 Query: 126 AGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLV 185 + + RV+ WGS +K+ V V V V VA G D +V Sbjct: 137 CFQN--FVVVQGTRVYGWGSNTKCQLQEPKSRSLKE-PVLVYDTGSVAVDYVAMGKDFMV 193 Query: 186 MLTADGD-LYTLGCGEQG---------------------QLGRVPELFANRGGRQGLERL 223 ++ G ++ G G L GR +L Sbjct: 194 IVDEGGRIVHASGRLPTGFELKQQQKRHNLVVLCMWTSIHLWNARLNTVESFGRGTHSQL 253 Query: 224 LVPKCVMLK----SRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279 + + + GS + G + + Y +G + G Sbjct: 254 FPQERLDFPIVGVATGSEHGILTTANQEGKSHCYNV------YCWGWGEHGNCGPQKGSQ 307 Score = 42.5 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 3/55 (5%) Query: 366 VFAWGMGTNYQLGTGQDEDAWSPVE-MMGKQLENRVVLSVSSGGQHTVLLVKDKE 419 V+A+G QLG G DED +P + G + +V ++ GG H+V+L D Sbjct: 4 VYAFGSNGQRQLGLGHDEDMDTPQRSVPGD--DGAIVRKIACGGNHSVMLTNDGN 56 >5Y7Y-B nrPDB Length = 311 Score = 33.7 bits (75), Expect = 0.17, Method: Composition-based stats. Identities = 13/72 (18%), Positives = 25/72 (34%), Gaps = 8/72 (11%) Query: 347 VSSVACGASVGYAVTKDGRVFAWGMGTNYQL-GTGQDEDAWSP-------VEMMGKQLEN 398 + + CG V G + AW G+ + L G+ + SP V + + Sbjct: 154 ICRMRCGNPHFVVVHCTGYIKAWPPGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISR 213 Query: 399 RVVLSVSSGGQH 410 + + + H Sbjct: 214 HNIEGIFTFVDH 225 >3W0L-B nrPDB Length = 619 Score = 29.8 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 15/65 (23%), Positives = 24/65 (36%), Gaps = 3/65 (4%) Query: 306 TVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGR 365 + +G Y LG G +G+ A E +PT + V G K+G Sbjct: 320 ATSLQKKGHLYILGWGTLGLVGI-MDAVEC-VPTYQADWRDVRGFITGGYHSIE-NKEGD 376 Query: 366 VFAWG 370 + + G Sbjct: 377 LSSLG 381 >5FVM-C nrPDB Length = 303 Score = 27.9 bits (60), Expect = 8.8, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 37/119 (31%), Gaps = 16/119 (13%) Query: 28 RSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQ 87 H + L+ G++ LGEN + + P + + G V + G Sbjct: 123 AIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGN 182 Query: 88 VYSFGCNDEGALGRDTSVEGSEMVP---------GKVELQEKVVQVS-AGDSHTAALTD 136 Y + + T E V +V L V ++ HTA + + Sbjct: 183 CYVW------RMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWN 235 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.120 0.305 Lambda K H 0.267 0.0366 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,221,035 Number of Sequences: 36641 Number of extensions: 544122 Number of successful extensions: 1571 Number of sequences better than 10.0: 11 Number of HSP's better than 10.0 without gapping: 17 Number of HSP's successfully gapped in prelim test: 13 Number of HSP's that attempted gapping in prelim test: 1222 Number of HSP's gapped (non-prelim): 79 length of query: 421 length of database: 10,336,785 effective HSP length: 100 effective length of query: 321 effective length of database: 6,672,685 effective search space: 2141931885 effective search space used: 2141931885 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 60 (27.9 bits)