BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P17516 (323 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2FVL-A nrPDB 668 0.0 5JM5-A nrPDB 567 e-162 4JQA-A nrPDB 556 e-159 1Q5M-A nrPDB 544 e-155 2HE8-A nrPDB 488 e-138 1AFS-A nrPDB 484 e-137 5UXF-A nrPDB 461 e-130 3G1R-A nrPDB 393 e-110 1ZUA-X nrPDB 308 3e-84 3RX4-A nrPDB 300 6e-82 1DLA-A nrPDB 296 1e-80 1C9W-A nrPDB 293 7e-80 3O3R-A nrPDB 285 2e-77 1FRB-A nrPDB 283 8e-77 4GAC-A nrPDB 280 8e-76 2ALR-A nrPDB 273 9e-74 1HQT-A nrPDB 268 3e-72 4HBK-A nrPDB 255 2e-68 3WCZ-A nrPDB 238 4e-63 3H7U-A nrPDB 215 2e-56 1QWK-A nrPDB 213 7e-56 5JH1-A nrPDB 213 7e-56 1VBJ-A nrPDB 208 2e-54 3H7R-A nrPDB 207 4e-54 2BGQ-A nrPDB 201 3e-52 1K8C-A nrPDB 198 3e-51 5ZCM-A nrPDB 197 4e-51 5Z6T-A nrPDB 191 5e-49 4F40-A nrPDB 187 5e-48 4GIE-A nrPDB 184 4e-47 3KRB-A nrPDB 181 3e-46 1VP5-A nrPDB 175 3e-44 3D3F-A nrPDB 168 4e-42 4IJC-A nrPDB 164 5e-41 1A80-A nrPDB 163 7e-41 4OTK-A nrPDB 161 3e-40 4MHB-A nrPDB 158 2e-39 3UP8-A nrPDB 157 5e-39 1MZR-A nrPDB 155 2e-38 3WG6-A nrPDB 135 2e-32 4H8N-A nrPDB 132 2e-31 1PZ1-A nrPDB 67 1e-11 1PYF-A nrPDB 66 2e-11 1GVE-A nrPDB 48 7e-06 2CLP-A nrPDB 45 3e-05 2BP1-A nrPDB 45 5e-05 1LQA-A nrPDB 44 7e-05 2C91-A nrPDB 44 1e-04 4R9O-A nrPDB 40 0.001 4EXA-A nrPDB 36 0.022 3N6Q-A nrPDB 35 0.045 1OG6-A nrPDB 35 0.058 3EB3-A nrPDB 33 0.16 4V4N-AM nrPDB 32 0.26 5LG6-A nrPDB 32 0.45 5LHD-A nrPDB 32 0.47 1V6C-A nrPDB 30 1.3 5F7C-A nrPDB 30 1.8 2RCY-A nrPDB 30 2.1 6GEJ-U nrPDB 29 2.1 3WVG-A nrPDB 28 4.2 4EO5-A nrPDB 28 6.2 4F3S-A nrPDB 28 6.8 >2FVL-A nrPDB Length = 324 Score = 668 bits (1723), Expect = 0.0, Method: Compositional matrix adjust. Identities = 321/323 (99%), Positives = 322/323 (99%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ Sbjct: 2 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 61 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM Sbjct: 62 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 121 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFN RQLEMILNKP Sbjct: 122 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP 181 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV Sbjct: 182 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 241 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 LCALAKKHK+TPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN Sbjct: 242 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 301 Query: 301 RNYRYVVMDFLMDHPDYPFSDEY 323 RNYRYVVMDFLMDHPDYPFSDEY Sbjct: 302 RNYRYVVMDFLMDHPDYPFSDEY 324 >5JM5-A nrPDB Length = 332 Score = 567 bits (1462), Expect = e-162, Method: Compositional matrix adjust. Identities = 271/323 (83%), Positives = 294/323 (91%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 MD K Q V+LNDGHFMPVLGFGTYAPPEVPR++A+EVTKLAIEAGFRHIDSA+LYNNEEQ Sbjct: 1 MDSKQQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ 60 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 VGLAIRSKIADGSVKREDIFYTSKLW TF +P++V+PALE+SLKK QLDYVDLYL+H PM Sbjct: 61 VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM 120 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 +LKPGE P DENGKVIFD VDL TWE MEKCKDAGLAKSIGVSNFN RQLEMILNKP Sbjct: 121 SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP 180 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 GLKYKPVCNQVECHPY N+SKLLDFCKSKDIVLVA+SALG+QR K WVDPNSPVLLEDPV Sbjct: 181 GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV 240 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 LCALAKKHK+TPALIALRYQLQRGVVVLAKSYNEQRIR+N+QVFEFQLT+EDMK +DGL+ Sbjct: 241 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD 300 Query: 301 RNYRYVVMDFLMDHPDYPFSDEY 323 RN Y D HP+YP+SDEY Sbjct: 301 RNLHYFNSDSFASHPNYPYSDEY 323 >4JQA-A nrPDB Length = 331 Score = 556 bits (1433), Expect = e-159, Method: Compositional matrix adjust. Identities = 263/323 (81%), Positives = 292/323 (90%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 MD KYQ V+LNDGHFMPVLGFGTYAP EVP+++A+E KLAIEAGF HIDSA++YNNEEQ Sbjct: 1 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ 60 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 VGLAIRSKIADGSVKREDIFYTSKLW +P++V+PALE SLK LQLDYVDLYL+HFP+ Sbjct: 61 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 120 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 ++KPGE +PKDENGK++FDTVDL ATWE MEKCKDAGLAKSIGVSNFN R LEMILNKP Sbjct: 121 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP 180 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 GLKYKPVCNQVECHPY NQ KLLDFCKSKDIVLVA+SALG+ R + WVDPNSPVLLEDPV Sbjct: 181 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 240 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 LCALAKKHK+TPALIALRYQLQRGVVVLAKSYNEQRIR+N+QVFEFQLTSE+MK +DGLN Sbjct: 241 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 300 Query: 301 RNYRYVVMDFLMDHPDYPFSDEY 323 RN RY+ +D P+YPFSDEY Sbjct: 301 RNVRYLTLDIFAGPPNYPFSDEY 323 >1Q5M-A nrPDB Length = 322 Score = 544 bits (1401), Expect = e-155, Method: Compositional matrix adjust. Identities = 252/322 (78%), Positives = 290/322 (90%) Query: 2 DPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQV 61 DPK+QRV L+DGHF+PVLGFGTYAP EVP+++A+E TK+AI+AGFRHIDSAY Y NE++V Sbjct: 1 DPKFQRVALSDGHFIPVLGFGTYAPEEVPKSKAMEATKIAIDAGFRHIDSAYFYKNEKEV 60 Query: 62 GLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMA 121 GLAIRSKIADG+VKREDIFYTSKLWCTF +P++V+P+LE SLK LQLDYVDLY++HFP A Sbjct: 61 GLAIRSKIADGTVKREDIFYTSKLWCTFHRPELVRPSLEDSLKNLQLDYVDLYIIHFPTA 120 Query: 122 LKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPG 181 LKPG +P DE+GK IFDTVD+ ATWE MEKCKDAGLAKSIGVSNFN RQLEMILNKPG Sbjct: 121 LKPGVEIIPTDEHGKAIFDTVDICATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPG 180 Query: 182 LKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVL 241 LKYKPVCNQVECHPYLNQ KLL+FCKSK IVLVA+SALG+ R WVD ++PVLLEDP++ Sbjct: 181 LKYKPVCNQVECHPYLNQGKLLEFCKSKGIVLVAYSALGSHREPEWVDQSAPVLLEDPLI 240 Query: 242 CALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNR 301 ALAKKH+QTPALIALRYQLQRG+VVLAKS+ E+RI+ENIQVFEFQL SEDMKV+D LNR Sbjct: 241 GALAKKHQQTPALIALRYQLQRGIVVLAKSFTEKRIKENIQVFEFQLPSEDMKVIDSLNR 300 Query: 302 NYRYVVMDFLMDHPDYPFSDEY 323 N+RYV DF + HP+YPFSDEY Sbjct: 301 NFRYVTADFAIGHPNYPFSDEY 322 >2HE8-A nrPDB Length = 323 Score = 488 bits (1256), Expect = e-138, Method: Compositional matrix adjust. Identities = 232/323 (71%), Positives = 271/323 (83%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 M+ K V LNDG+F+PVLGFGT P E P+++A E+TK+AI+AGF H DSA +YN E+ Sbjct: 1 MNSKCHCVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDH 60 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 VG AIRSKIADG+V+REDIFYTSK+WCT P++V+ +LE SL+KLQ DYVDLYL+H+PM Sbjct: 61 VGEAIRSKIADGTVRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPM 120 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 ALKPGE P DE+GK+IFD VDL ATWE MEKCKDAGL KSIGVSNFN RQLEMILNKP Sbjct: 121 ALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKP 180 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 GLKYKPVCNQVECHPYLNQ KLLDFCKSKDIVLVA+ LGTQR+ WVD NSPVLL++PV Sbjct: 181 GLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPV 240 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 L ++AKK+ +TPALIALRYQLQRG+VVL S E+RI+EN+QVFEFQL+SEDMKVLDGLN Sbjct: 241 LGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLN 300 Query: 301 RNYRYVVMDFLMDHPDYPFSDEY 323 RN RY+ HP++PF DEY Sbjct: 301 RNMRYIPAAIFKGHPNWPFLDEY 323 >1AFS-A nrPDB Length = 323 Score = 484 bits (1245), Expect = e-137, Method: Compositional matrix adjust. Identities = 224/322 (69%), Positives = 269/322 (83%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 MD RV LNDG+F+PVLGFGT P +V ++ ++ TK+AI+ GFRH DSAYLY EE+ Sbjct: 1 MDSISLRVALNDGNFIPVLGFGTTVPEKVAKDEVIKATKIAIDNGFRHFDSAYLYEVEEE 60 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 VG AIRSKI DG+VKREDIFYTSKLW TF +P++V+ LE +LK QLDYVDLY++HFPM Sbjct: 61 VGQAIRSKIEDGTVKREDIFYTSKLWSTFHRPELVRTCLEKTLKSTQLDYVDLYIIHFPM 120 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 AL+PG+ P+DE+GK++F+TVD+ TWE MEKCKDAGLAKSIGVSNFNCRQLE ILNKP Sbjct: 121 ALQPGDIFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILNKP 180 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 GLKYKPVCNQVECH YLNQSK+LD+CKSKDI+LV++ LG+ R K WVD SPVLL+DPV Sbjct: 181 GLKYKPVCNQVECHLYLNQSKMLDYCKSKDIILVSYCTLGSSRDKTWVDQKSPVLLDDPV 240 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 LCA+AKK+KQTPAL+ALRYQLQRGVV L +S+N +RI+E QVFEFQL SEDMK LDGLN Sbjct: 241 LCAIAKKYKQTPALVALRYQLQRGVVPLIRSFNAKRIKELTQVFEFQLASEDMKALDGLN 300 Query: 301 RNYRYVVMDFLMDHPDYPFSDE 322 RN+RY + DHP++PF+DE Sbjct: 301 RNFRYNNAKYFDDHPNHPFTDE 322 >5UXF-A nrPDB Length = 342 Score = 461 bits (1187), Expect = e-130, Method: Compositional matrix adjust. Identities = 213/323 (65%), Positives = 266/323 (82%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 M K V+LNDGH +P LGFGTY P EVP+++++E LA++ G+RH+D+AY Y EE+ Sbjct: 20 MSSKQHCVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEEE 79 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 +G AI+S IA G VKRED+F T+KLWCT F+P++V+PALE SLKKLQLDYVDLY++H+P+ Sbjct: 80 IGQAIQSAIAAGVVKREDLFVTTKLWCTCFRPELVKPALEKSLKKLQLDYVDLYIMHYPV 139 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 +K G+ P +E GK + DTVD TWE +E+CKDAGL KSIGVSNFN RQLE ILNKP Sbjct: 140 PMKSGDNDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKP 199 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 GLKYKPVCNQVECH YLNQ KLLD+C+SKDIVLVA+ ALGTQR+K WVD NSPVLL DPV Sbjct: 200 GLKYKPVCNQVECHLYLNQRKLLDYCESKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPV 259 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 LC +AKK+K++PALIALRY +QRG+V LA+S+ E +REN+QVF FQL+ EDMK LDGLN Sbjct: 260 LCDVAKKNKRSPALIALRYLIQRGIVPLAQSFKENEMRENLQVFGFQLSPEDMKTLDGLN 319 Query: 301 RNYRYVVMDFLMDHPDYPFSDEY 323 +N+RY+ +FL+DHP+YPF +EY Sbjct: 320 KNFRYLPAEFLVDHPEYPFVEEY 342 >3G1R-A nrPDB Length = 346 Score = 393 bits (1010), Expect = e-110, Method: Compositional matrix adjust. Identities = 181/319 (56%), Positives = 239/319 (74%), Gaps = 1/319 (0%) Query: 6 QRVELNDGHFMPVLGFGTYAPPE-VPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLA 64 R+ L+DG+ +P++G GTY+ P+ P+ K+AI+ G+RHID AY+Y NE +VG A Sbjct: 28 HRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEA 87 Query: 65 IRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKP 124 IR KIA+G V+REDIFY KLW T P+MV+P LE +L+ LQLDYVDLY++ PMA KP Sbjct: 88 IREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKP 147 Query: 125 GETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKY 184 G+ P+DENGK ++ +L ATWE ME CKDAGL KS+GVSNFN RQLE+ILNKPGLK+ Sbjct: 148 GDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKH 207 Query: 185 KPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCAL 244 KPV NQVECHPY Q KLL FC+ DIV+ A+S LGT R+ +WV+ +SP LL+D +L +L Sbjct: 208 KPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSL 267 Query: 245 AKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYR 304 K++ +T A I LR+ +QRGVVV+ KS+N +RI+EN Q+F+F LT E+MK ++ LN+N R Sbjct: 268 GKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVR 327 Query: 305 YVVMDFLMDHPDYPFSDEY 323 +V + DHP+YPF DEY Sbjct: 328 FVELLMWRDHPEYPFHDEY 346 >1ZUA-X nrPDB Length = 317 Score = 308 bits (788), Expect = 3e-84, Method: Compositional matrix adjust. Identities = 152/316 (48%), Positives = 207/316 (65%), Gaps = 4/316 (1%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 VEL+ MP++G GT+ + P + E K+AI+AG+RHID AY+Y NE +VG AI+ Sbjct: 6 VELSTKAKMPIVGLGTW---KSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQE 62 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 KI + +VKRED+F SKLW TFF+ +V+ A E +LK L+L Y+D+YL+H+P K G+ Sbjct: 63 KIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDD 122 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187 PKD+ G I WE ME+ D GL K++GVSNF+ Q+E +LNKPGLKYKPV Sbjct: 123 LFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPV 182 Query: 188 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 247 NQVECHPYL Q KL+ +C SK I + A+S LG+ + W P P LLEDP + +A K Sbjct: 183 TNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSP-DRPWAKPEDPSLLEDPKIKEIAAK 241 Query: 248 HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVV 307 HK+T A + +R+ +QR V+V+ KS RI ENIQVF+F+L+ E+M + NRN+R Sbjct: 242 HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN 301 Query: 308 MDFLMDHPDYPFSDEY 323 + DYPF+ EY Sbjct: 302 VLQSSHLEDYPFNAEY 317 >3RX4-A nrPDB Length = 336 Score = 300 bits (768), Expect = 6e-82, Method: Compositional matrix adjust. Identities = 152/317 (47%), Positives = 216/317 (68%), Gaps = 4/317 (1%) Query: 7 RVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIR 66 R+ LN+G MP+LG GT+ + P + E K+AI+ G+RHID A++Y NE +VG+AI+ Sbjct: 24 RLLLNNGAKMPILGLGTW---KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ 80 Query: 67 SKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE 126 K+ + VKRE++F SKLWCT+ + +V+ A + +L L+LDY+DLYL+H+P KPG+ Sbjct: 81 EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK 140 Query: 127 TPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKP 186 P DE+G V+ ++ TW ME+ D GL K+IG+SNFN Q+EMILNKPGLKYKP Sbjct: 141 EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP 200 Query: 187 VCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAK 246 NQ+ECHPYL Q KL+ +C+SK IV+ A+S LG+ + W P P LLEDP + A+A Sbjct: 201 AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSP-DRPWAKPEDPSLLEDPRIKAIAA 259 Query: 247 KHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYV 306 KH +T A + +R+ +QR +VV+ KS +RI EN +VF+F+L+S+DM L NRN+R Sbjct: 260 KHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVC 319 Query: 307 VMDFLMDHPDYPFSDEY 323 + H DYPF +E+ Sbjct: 320 ALLSCTSHKDYPFHEEF 336 >1DLA-A nrPDB Length = 314 Score = 296 bits (757), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 153/314 (48%), Positives = 210/314 (66%), Gaps = 4/314 (1%) Query: 10 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKI 69 L G MP+LG GT+ + P + E K+AI+ G+RHID A++Y NE +VGL ++ K+ Sbjct: 5 LYTGAKMPILGLGTW---KSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEKL 61 Query: 70 ADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPL 129 VKRED+F SKLWCT + +V+ A +++L+ L+LDY+DLYL+H+P KPG+ P Sbjct: 62 QGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKDPF 121 Query: 130 PKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCN 189 P D +G V+ D D TWE ME+ D GL K+IGVSNFN Q+E ILNKPGLKYKP N Sbjct: 122 PLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVN 181 Query: 190 QVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHK 249 Q+E HPYL Q KL+++CKSK IV+ A+S LG+ + W P P LLEDP + A+A K+ Sbjct: 182 QIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSP-DRPWAKPEDPSLLEDPRIKAIAAKYN 240 Query: 250 QTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVVMD 309 +T A + +R+ +QR ++V+ KS +RI EN QVF+F+L+ EDM L NRN+R + Sbjct: 241 KTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCALM 300 Query: 310 FLMDHPDYPFSDEY 323 H DYPF +EY Sbjct: 301 SCASHKDYPFHEEY 314 >1C9W-A nrPDB Length = 315 Score = 293 bits (750), Expect = 7e-80, Method: Compositional matrix adjust. Identities = 151/316 (47%), Positives = 215/316 (68%), Gaps = 4/316 (1%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 VEL+ MP++G GT+ + P + E K+AI+AG+RHID AY Y NE +VG AI+ Sbjct: 4 VELSTKAKMPIVGLGTW---QSPPGQVKEAVKVAIDAGYRHIDCAYAYYNEHEVGEAIQE 60 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 KI + +V+RED+F SKLW T F+ ++++ A + +L L+LDY+DLYL+H+P L+PG+ Sbjct: 61 KIKEKAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKE 120 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187 PKD+ G V+ + WEVME+ D GL K++GVSNFN Q+E ILNKPGLK+KPV Sbjct: 121 LFPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILNKPGLKHKPV 180 Query: 188 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 247 NQVECHPYL Q KL+++C SK I + A+S LG+ ++ W P P LLEDP + +A K Sbjct: 181 TNQVECHPYLTQEKLIEYCHSKGITVTAYSPLGSP-NRPWAKPEDPSLLEDPKIKEIAAK 239 Query: 248 HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVV 307 HK+T A + +R+ +QR VVV+ KS RI EN QVF+FQL+ ++M + G NRN+R + Sbjct: 240 HKKTSAQVLIRFHIQRNVVVIPKSVTPARIHENFQVFDFQLSDQEMATILGFNRNWRACL 299 Query: 308 MDFLMDHPDYPFSDEY 323 + ++ +YP+ EY Sbjct: 300 LPETVNMEEYPYDAEY 315 >3O3R-A nrPDB Length = 316 Score = 285 bits (728), Expect = 2e-77, Method: Compositional matrix adjust. Identities = 150/316 (47%), Positives = 208/316 (65%), Gaps = 4/316 (1%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 V+L MP++G GT+ P + E K AI+AG+RH D AY+Y NE +VG AI+ Sbjct: 5 VKLRTKAKMPLVGLGTWKSPP---GQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQE 61 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 KI + +V+RED+F SKLW TFF+ +++ A + +L L+LDY+DLYL+H+P L+ G+ Sbjct: 62 KIKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGKE 121 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187 LPKD GKV+ WE ME+ D GL K++GVSNFN Q+E +LNKPGLK+KPV Sbjct: 122 FLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPV 181 Query: 188 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 247 NQVECHPYL Q KL+ +C SK I ++A+S LG+ + + P PV+LE P + +A K Sbjct: 182 TNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSP-DRPYAKPEDPVVLEIPKIKEIAAK 240 Query: 248 HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVV 307 HK+T A + +R+ +QR V V+ KS I+ENIQVF+FQL+ EDM + LNRN+R Sbjct: 241 HKKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRACG 300 Query: 308 MDFLMDHPDYPFSDEY 323 + D D+PF +EY Sbjct: 301 LFVTSDEEDFPFHEEY 316 >1FRB-A nrPDB Length = 315 Score = 283 bits (723), Expect = 8e-77, Method: Compositional matrix adjust. Identities = 148/316 (46%), Positives = 212/316 (67%), Gaps = 4/316 (1%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 VEL+ MP++G GT+ + P N+ E K AI+AG+RHID AY Y NE +VG AI+ Sbjct: 4 VELSTKAKMPIVGLGTW---KSPPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQE 60 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 KI + +V+RED+F SKLW T F+ ++++ A + +L L+LDY+DLYL+H+P L+PG+ Sbjct: 61 KIKEKAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKE 120 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187 PKD+ G+++ WE ME+ D GL K++GVSNFN Q+E +LNKPGLK+KPV Sbjct: 121 LFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPV 180 Query: 188 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 247 NQVECHPYL Q KL+ +C SK I + A+S LG+ + P P LLEDP + +A K Sbjct: 181 TNQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSP-DRPSAKPEDPSLLEDPKIKEIAAK 239 Query: 248 HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVV 307 H++T A + +R+ +QR VVV+ KS RI+ENIQVF+FQL+ E+M + NRN+R + Sbjct: 240 HEKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWRACL 299 Query: 308 MDFLMDHPDYPFSDEY 323 + ++ +YP+ EY Sbjct: 300 LPETVNMEEYPYDAEY 315 >4GAC-A nrPDB Length = 324 Score = 280 bits (715), Expect = 8e-76, Method: Compositional matrix adjust. Identities = 141/326 (43%), Positives = 210/326 (64%), Gaps = 16/326 (4%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 V L+ G MP++G GT+ A+ K A+ AG+RHID A +Y NE ++G A++ Sbjct: 5 VLLHTGQKMPLIGLGTWKSEPGQVKAAI---KHALSAGYRHIDCASVYGNETEIGEALKE 61 Query: 68 KIADG-SVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE 126 + G +V RE++F TSKLW T P+ V+PAL +L LQL+Y+DLYL+H+P A + G+ Sbjct: 62 SVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 121 Query: 127 TPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKP 186 P PK+ +G V +D+ TW+ +E GL K++G+SNFN RQ++ +L+ + +P Sbjct: 122 NPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--RP 179 Query: 187 VCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAK 246 QVECHPYL Q++L+ C ++ + + A+S LG+ + W P+ PVLLE+PV+ ALA+ Sbjct: 180 AVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSS-DRAWRHPDEPVLLEEPVVLALAE 238 Query: 247 KHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYV 306 KH ++PA I LR+Q+QR V+ + KS N RI +NIQVF+F + E+MK LD LN+N+RY+ Sbjct: 239 KHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYI 298 Query: 307 VMDFLMD---------HPDYPFSDEY 323 V +D HP YPF+D Y Sbjct: 299 VPMITVDGKRVPRDAGHPLYPFNDPY 324 >2ALR-A nrPDB Length = 324 Score = 273 bits (697), Expect = 9e-74, Method: Compositional matrix adjust. Identities = 137/326 (42%), Positives = 210/326 (64%), Gaps = 16/326 (4%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 V L+ G MP++G GT+ AV K A+ G+RHID A +Y NE ++G A++ Sbjct: 5 VLLHTGQKMPLIGLGTWKSEPGQVKAAV---KYALSVGYRHIDCAAIYGNEPEIGEALKE 61 Query: 68 KIADG-SVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE 126 + G +V RE++F TSKLW T P+ V+PAL +L LQL+Y+DLYL+H+P A + G+ Sbjct: 62 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 121 Query: 127 TPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKP 186 P PK+ +G + +D+ TW+ +E GL +++G+SNFN RQ++ IL+ + +P Sbjct: 122 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--RP 179 Query: 187 VCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAK 246 QVECHPYL Q++L+ C+++ + + A+S LG+ + W DP+ PVLLE+PV+ ALA+ Sbjct: 180 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVVLALAE 238 Query: 247 KHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYV 306 K+ ++PA I LR+Q+QR V+ + KS RI +NI+VF+F + E+MK L+ LN+N+RY+ Sbjct: 239 KYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYI 298 Query: 307 VMDFLMD---------HPDYPFSDEY 323 V +D HP YPF+D Y Sbjct: 299 VPMLTVDGKRVPRDAGHPLYPFNDPY 324 >1HQT-A nrPDB Length = 326 Score = 268 bits (684), Expect = 3e-72, Method: Compositional matrix adjust. Identities = 134/326 (41%), Positives = 208/326 (63%), Gaps = 16/326 (4%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 V L+ G MP++G GT+ + + K A+ G+RHID A ++ NE ++G A++ Sbjct: 7 VLLHTGQKMPLIGLGTW---KSEPGQVKAAIKYALTVGYRHIDCAAIFGNELEIGEALQE 63 Query: 68 KIADG-SVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE 126 + G +V RE++F TSKLW T P+ V+PAL +L LQL+Y+DLYL+H+P A + G+ Sbjct: 64 TVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 123 Query: 127 TPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKP 186 P PK+ +G + +D TW+ +E GL +++G+SNF+ RQ++ +L+ + +P Sbjct: 124 NPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVASV--RP 181 Query: 187 VCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAK 246 QVECHPYL Q++L+ C+++ + + A+S LG+ + W DPN PVLLE+PV+ ALA+ Sbjct: 182 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPNEPVLLEEPVVQALAE 240 Query: 247 KHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYV 306 K+ ++PA I LR+Q+QR V+ + KS RI +NIQVF+F + E+MK LD LN+N R++ Sbjct: 241 KYNRSPAQILLRWQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALNKNLRFI 300 Query: 307 VMDFLMD---------HPDYPFSDEY 323 V +D HP YPF+D Y Sbjct: 301 VPMLTVDGKRVPRDAGHPLYPFNDPY 326 >4HBK-A nrPDB Length = 344 Score = 255 bits (652), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 134/316 (42%), Positives = 197/316 (62%), Gaps = 9/316 (2%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 +++N+G +PV+G GT+ P AV K A+E G+RH+D AY+Y NE ++G A+ + Sbjct: 38 LKMNNGRSIPVIGLGTWNSPPGEVGAAV---KKALEIGYRHLDCAYVYRNEAEIGEALEN 94 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 + +KREDIF TSKLW TFF+P+ V+ A E +LK L+L+Y+DLYL+H+P+ LK G Sbjct: 95 ALNSLRLKREDIFITSKLWNTFFRPEHVRKACEETLKNLRLNYLDLYLIHWPVPLKHGGD 154 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187 P D NG++ D V TW+ MEK D GL KSIG+SNFN RQ++ IL + KP Sbjct: 155 LFPTDSNGQLCLDNVPHEDTWKEMEKLVDEGLVKSIGLSNFNKRQIQNILEH--CRIKPA 212 Query: 188 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 247 Q+E H KL+++ +S + + A++ LG+ H P LL P + +A + Sbjct: 213 NLQIEIHANFPNIKLVEYAQSVGLTVTAYAPLGSPAH----SPGKVNLLTKPCVLEIAHR 268 Query: 248 HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVV 307 HK+TPA + LRY LQR ++V+ KS +RI EN QVF+FQL++E+M L+ + N R Sbjct: 269 HKKTPAQVLLRYLLQRKLIVVPKSVTFKRIEENFQVFDFQLSNEEMHELNTESLNERQFT 328 Query: 308 MDFLMDHPDYPFSDEY 323 + + H +YPF +EY Sbjct: 329 LLQMSGHQEYPFKEEY 344 >3WCZ-A nrPDB Length = 308 Score = 238 bits (606), Expect = 4e-63, Method: Compositional matrix adjust. Identities = 127/316 (40%), Positives = 191/316 (60%), Gaps = 21/316 (6%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKL---AIEAGFRHIDSAYLYNNEEQVGLA 64 ++LNDG+ +P++ GT + EV + AIEAG+RHID+A +Y +EEQVG Sbjct: 8 IQLNDGNTIPIVALGTGRGTAKESDSIDEVRQAVYWAIEAGYRHIDTAAVYQDEEQVGQG 67 Query: 65 IRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKP 124 I IA+G V RE++F T+KLW V PAL+ SLKKL LDY+DLYL+HFP+A KP Sbjct: 68 IAEAIANGLVTREELFVTTKLWNDKHARDQVVPALQESLKKLGLDYIDLYLIHFPIATKP 127 Query: 125 GETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKY 184 ++P D +D TW+ M+ + GLA+SIGVSNFN Q+ +++ + Sbjct: 128 DDSP-----------DNIDYLETWQGMQDARQLGLARSIGVSNFNATQITRLVSNSYI-- 174 Query: 185 KPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALG--TQRHKLWVDPNSPVLLEDPVLC 242 +PV NQ+E +P Q L+ C+S I ++A+S G R + P +DP L Sbjct: 175 RPVINQIEVNPTNTQEPLVAHCQSLGIAVMAYSPFGFVVSRGQTGAPPPRS---DDPTLT 231 Query: 243 ALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRN 302 ALA K++++ I LRY + RG++ + KS N+QRI +NI +F+FQLT E++ ++ N+N Sbjct: 232 ALANKYRKSVGQILLRYLIDRGLIPIPKSTNKQRIAQNIDLFDFQLTFEEVAAINQFNKN 291 Query: 303 YRYVVMDFLMDHPDYP 318 +R + + D+P+YP Sbjct: 292 HRVIDISDWKDYPNYP 307 >3H7U-A nrPDB Length = 335 Score = 215 bits (548), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 119/280 (42%), Positives = 172/280 (61%), Gaps = 14/280 (5%) Query: 9 ELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSK 68 +LN G P +G GT+ + + A++ G+RHID A +Y NE+++G ++ Sbjct: 29 KLNTGAKFPSVGLGTW---QASPGLVGDAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKL 85 Query: 69 IADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETP 128 D VKRED+F TSKLWCT PQ V AL +LK LQL+YVDLYL+H+P +K G Sbjct: 86 FEDRVVKREDLFITSKLWCTDHDPQDVPEALNRTLKDLQLEYVDLYLIHWPARIKKGSVG 145 Query: 129 LPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVC 188 + K EN VD+ +TW+ ME D+G A++IGVSNF+ ++L +L + P Sbjct: 146 I-KPEN----LLPVDIPSTWKAMEALYDSGKARAIGVSNFSTKKLADLLELA--RVPPAV 198 Query: 189 NQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKH 248 NQVECHP Q+KL +FCKSK + L A+S LG+ W+ + +L++P+L +A+K Sbjct: 199 NQVECHPSWRQTKLQEFCKSKGVHLSAYSPLGSP-GTTWLKSD---VLKNPILNMVAEKL 254 Query: 249 KQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQL 288 ++PA +ALR+ LQ G VL KS NE RI+EN VF++ + Sbjct: 255 GKSPAQVALRWGLQMGHSVLPKSTNEGRIKENFNVFDWSI 294 >1QWK-A nrPDB Length = 317 Score = 213 bits (543), Expect = 7e-56, Method: Compositional matrix adjust. Identities = 127/333 (38%), Positives = 183/333 (54%), Gaps = 29/333 (8%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTY--APPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNE 58 M ++L++G MPV+G GT+ +P EV + K A++AG+R ID+A +Y NE Sbjct: 1 MSSATASIKLSNGVEMPVIGLGTWQSSPAEV-----ITAVKTAVKAGYRLIDTASVYQNE 55 Query: 59 EQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHF 118 E +G AI+ + +G VKRE++F T+K W P ++ L SLKKLQL+YVDLYL H Sbjct: 56 EAIGTAIKELLEEGVVKREELFITTKAWTHELAPGKLEGGLRESLKKLQLEYVDLYLAHM 115 Query: 119 PMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILN 178 P A D+ + I V+ W + AGLAK++GVSN+N Q+ L Sbjct: 116 PAAF--------NDDMSEHIASPVE--DVWRQFDAVYKAGLAKAVGVSNWNNDQISRAL- 164 Query: 179 KPGLKYKPVCN-QVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPN------ 231 L PV N QVE H Y Q +DFCK +I + +++ LG+ + P Sbjct: 165 --ALGLTPVHNSQVELHLYFPQHDHVDFCKKHNISVTSYATLGSPGRVNFTLPTGQKLDW 222 Query: 232 --SPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLT 289 +P L+D + ALA+K +TPA + LRY L RG +L KS E RI+EN +VF+F LT Sbjct: 223 APAPSDLQDQNVLALAEKTHKTPAQVLLRYALDRGCAILPKSIQENRIKENFEVFDFSLT 282 Query: 290 SEDMKVLDGLNRNYRYVVMDFLMDHPDYPFSDE 322 ED+ L+ + R + DF+ HP+ F+ E Sbjct: 283 EEDIAKLEESKNSQRLFLQDFMTGHPEDAFAAE 315 >5JH1-A nrPDB Length = 309 Score = 213 bits (543), Expect = 7e-56, Method: Compositional matrix adjust. Identities = 116/280 (41%), Positives = 175/280 (62%), Gaps = 17/280 (6%) Query: 10 LNDGHFMPVLGFGTY-APPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSK 68 LN G +P +G G++ + P V N A++AG+RHID A +Y NE+++GLA++ Sbjct: 6 LNTGAKIPSVGLGSWQSDPGVVGN----AVYAAVKAGYRHIDCARVYGNEKEIGLALKKL 61 Query: 69 IADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETP 128 +G VKRED+F TSKLW P+ V AL SL LQL+Y+DLYL+H+P +K G Sbjct: 62 FEEGVVKREDMFITSKLWNDHHAPEDVPEALNDSLNDLQLEYLDLYLIHWPFRVKKGTNT 121 Query: 129 LPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVC 188 P++ F T D ATW MEK DAG A++IGVSNF+ ++L +L + P Sbjct: 122 SPEN------FVTPDFPATWGAMEKLYDAGKARAIGVSNFSSKKLGDLLAVA--RVPPAV 173 Query: 189 NQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKH 248 +QVECHP Q+KL FC+S + L A+S LG+ W++ N +L++P++ ++A+K Sbjct: 174 DQVECHPGWQQTKLHSFCQSTGVHLTAYSPLGSPG-TTWMNGN---VLKEPIIISIAEKL 229 Query: 249 KQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQL 288 +T A +ALR+ +Q G VL KS NE+RI++N+ V+++ + Sbjct: 230 GKTSAQVALRWNIQMGHSVLPKSTNEERIKQNLDVYDWSI 269 >1VBJ-A nrPDB Length = 281 Score = 208 bits (530), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 123/300 (41%), Positives = 176/300 (58%), Gaps = 39/300 (13%) Query: 6 QRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAI 65 Q ++L++G MPVLGFG + + N A T AI++G+RHID+A +Y NEE G AI Sbjct: 10 QSLKLSNGVMMPVLGFGMWKLQD--GNEAETATMWAIKSGYRHIDTAAIYKNEESAGRAI 67 Query: 66 RSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPG 125 A V RE++F T+KLW + + A E S+KKL L+YVDLYL+H+P Sbjct: 68 ----ASCGVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLIHWP------ 117 Query: 126 ETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYK 185 GK F +D TW+ EK ++IGVSNF+ +E +L K Sbjct: 118 ---------GKDKF--ID---TWKAFEKLYADKKVRAIGVSNFHEHHIEELLKH--CKVA 161 Query: 186 PVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALA 245 P+ NQ+E HP LNQ L ++CKSK+I + A S LG Q H L+ED L A+ Sbjct: 162 PMVNQIELHPLLNQKALCEYCKSKNIAVTAWSPLG-QGH----------LVEDARLKAIG 210 Query: 246 KKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRY 305 K+ +T A + LR+++Q GV+ + KS NE RI+EN +F+F+LT+ED++V+DG+N +RY Sbjct: 211 GKYGKTAAQVMLRWEIQAGVITIPKSGNEARIKENGNIFDFELTAEDIQVIDGMNAGHRY 270 >3H7R-A nrPDB Length = 331 Score = 207 bits (528), Expect = 4e-54, Method: Compositional matrix adjust. Identities = 114/280 (40%), Positives = 170/280 (60%), Gaps = 18/280 (6%) Query: 9 ELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSK 68 ELN G +P +G GTYA + AI+ G+RHID A +Y NE+++G ++ Sbjct: 29 ELNTGAKLPCVGLGTYA-------MVATAIEQAIKIGYRHIDCASIYGNEKEIGGVLKKL 81 Query: 69 IADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETP 128 I DG VKRE++F TSKLW P+ V ALE +L+ LQ+DYVDLYL+H+P +LK E+ Sbjct: 82 IGDGFVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPASLKK-ESL 140 Query: 129 LPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVC 188 +P E + D+++TW+ ME D+G A++IGVSNF+ ++L +LN + P Sbjct: 141 MPTPE----MLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVA--RVTPAV 194 Query: 189 NQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKH 248 NQVECHP Q L + CKSK + L +S LG+Q +L++P++ +A+K Sbjct: 195 NQVECHPVWQQQGLHELCKSKGVHLSGYSPLGSQSK----GEVRLKVLQNPIVTEVAEKL 250 Query: 249 KQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQL 288 +T A +ALR+ LQ G VL KS + R++EN+ VF++ + Sbjct: 251 GKTTAQVALRWGLQTGHSVLPKSSSGARLKENLDVFDWSI 290 >2BGQ-A nrPDB Length = 344 Score = 201 bits (511), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 113/302 (37%), Positives = 166/302 (54%), Gaps = 19/302 (6%) Query: 10 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKI 69 L GH MP +G GT+ + A V EAG+RH+D+A Y E++VG +++ + Sbjct: 42 LKSGHAMPAVGLGTW---RAGSDTAHSVRTAITEAGYRHVDTAAEYGVEKEVGKGLKAAM 98 Query: 70 ADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPL 129 G + R+D+F TSK+WCT P+ V+PALE++LK LQLDY+DLY +H+P LK G Sbjct: 99 EAG-IDRKDLFVTSKIWCTNLAPERVRPALENTLKDLQLDYIDLYHIHWPFRLKDGAHMP 157 Query: 130 PKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCN 189 P E G+V+ D+ W+ ME GL K IGV N+ +L +L K P Sbjct: 158 P--EAGEVL--EFDMEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLRSA--KIPPAVC 211 Query: 190 QVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHK 249 Q+E HP K+ + CK I + A+S LG+ L DPV+ +A K Sbjct: 212 QMEMHPGWKNDKIFEACKKHGIHITAYSPLGSSEKN---------LAHDPVVEKVANKLN 262 Query: 250 QTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVVMD 309 +TP + +++ LQRG V+ KS ++RI+ENIQVF +++ ED KVL + R + + Sbjct: 263 KTPGQVLIKWALQRGTSVIPKSSKDERIKENIQVFGWEIPEEDFKVLCSIKDEKRVLTGE 322 Query: 310 FL 311 L Sbjct: 323 EL 324 >1K8C-A nrPDB Length = 322 Score = 198 bits (503), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 117/314 (37%), Positives = 172/314 (54%), Gaps = 14/314 (4%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 M ++L+ GH MP +GFG + ++ A E AI+AG+R D A Y NE++ Sbjct: 1 MSASIPDIKLSSGHLMPSIGFGCW---KLANATAGEQVYQAIKAGYRLFDGAEDYGNEKE 57 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 VG ++ I +G VKRE+IF TSKLW + P+ V+ AL +L L++DYVDL+L+HFP+ Sbjct: 58 VGDGVKRAIDEGLVKREEIFLTSKLWNNYHDPKNVETALNKTLADLKVDYVDLFLIHFPI 117 Query: 121 ALK--PGETPLPK----DENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLE 174 A K P E P + +++ V + TW+ +EK AG KSIGVSNF L Sbjct: 118 AFKFVPIEEKYPPGFYCGDGNNFVYEDVPILETWKALEKLVAAGKIKSIGVSNFPGALLL 177 Query: 175 MILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRH---KLWVDPN 231 +L G KP QVE HPYL Q KL++F + + + A+S+ G Q N Sbjct: 178 DLLR--GATIKPAVLQVEHHPYLQQPKLIEFAQKAGVTITAYSSFGPQSFVEMNQGRALN 235 Query: 232 SPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSE 291 +P L + A+A K+ +TPA + LR+ QRG+ V+ KS +R+ +N F LT E Sbjct: 236 TPTLFAHDTIKAIAAKYNKTPAEVLLRWAAQRGIAVIPKSNLPERLVQNRSFNTFDLTKE 295 Query: 292 DMKVLDGLNRNYRY 305 D + + L+ R+ Sbjct: 296 DFEEIAKLDIGLRF 309 >5ZCM-A nrPDB Length = 341 Score = 197 bits (502), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 108/309 (34%), Positives = 181/309 (58%), Gaps = 18/309 (5%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 ++LN G+ MP++GFG + +V + AI+ G+R D+A Y N +++G I Sbjct: 24 IKLNSGYEMPLVGFGCW---KVDNATCADTVYNAIKVGYRLFDAAMDYGNCKEIGEGINR 80 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK--PG 125 + +G V R+++F TSKLW ++ P+ V+ AL+ L ++LDY+DL+L+HFP+A K P Sbjct: 81 ALDEGLVARDELFITSKLWNSYHDPKNVELALKKVLSDMKLDYIDLFLIHFPIAFKFVPF 140 Query: 126 ETPLPK----DENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPG 181 E P + ++ V L TW+ MEK G AKSIG+SNF+ + +L G Sbjct: 141 EEKYPPAFYCGDGDNFHYEDVPLLETWKAMEKLTKGGKAKSIGISNFSAALIYDLLR--G 198 Query: 182 LKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQ-----RHKLWVDPNSPVLL 236 + KP Q+E HPYL Q +L+++ +S+ I + A+S+ G Q +H +D +P L Sbjct: 199 AEIKPAVLQIEHHPYLQQPRLIEYVQSQGIAITAYSSFGPQSFLELKHSKALD--TPTLF 256 Query: 237 EDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVL 296 E + ++A K+K+TPA + LR+ QR + ++ KS N R+ +N++V +F L+ ED + Sbjct: 257 EHKTITSIADKYKKTPAQVLLRWASQRDIAIIPKSNNPDRLLQNLEVNDFNLSKEDFDEI 316 Query: 297 DGLNRNYRY 305 L+++ R+ Sbjct: 317 SKLDQDLRF 325 >5Z6T-A nrPDB Length = 343 Score = 191 bits (484), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 115/307 (37%), Positives = 168/307 (54%), Gaps = 14/307 (4%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 ++LN G+ MP +GFG + +V + E AI+ G+R D A Y NE+ VG ++ Sbjct: 29 IKLNSGYDMPAVGFGCW---KVDVDTCSEQIYRAIKTGYRLFDGAEDYANEKLVGAGVKK 85 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK--PG 125 I +G VKRED+F TSKLW + P V+ AL +L LQ+DYVDL+L+HFP+ K P Sbjct: 86 AIDEGIVKREDLFLTSKLWNNYHHPDNVEKALNRTLSDLQVDYVDLFLIHFPVTFKFVPL 145 Query: 126 ETPLPK----DENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPG 181 E P + ++ V + TW+ +EK AG +SIGVSNF L +L G Sbjct: 146 EEKYPPGFYCGKGDNFDYEDVPILETWKALEKLVKAGKIRSIGVSNFPGALLLDLLR--G 203 Query: 182 LKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRH---KLWVDPNSPVLLED 238 KP QVE HPYL Q +L++F +S+ I + A+S+ G Q N+ L E+ Sbjct: 204 ATIKPSVLQVEHHPYLQQPRLIEFAQSRGIAVTAYSSFGPQSFVELNQGRALNTSPLFEN 263 Query: 239 PVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDG 298 + A+A KH ++PA + LR+ QRG+ ++ KS R+ EN V F L +D + Sbjct: 264 ETIKAIAAKHGKSPAQVLLRWSSQRGIAIIPKSNTVPRLLENKDVNSFDLDEQDFADIAK 323 Query: 299 LNRNYRY 305 L+ N R+ Sbjct: 324 LDINLRF 330 >4F40-A nrPDB Length = 288 Score = 187 bits (476), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 113/300 (37%), Positives = 163/300 (54%), Gaps = 35/300 (11%) Query: 8 VELNDGHFMPVLGFGTYAPP--EVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAI 65 V L++G MP G G + P EV N K A+ AG+RHID+A +Y NEE VG + Sbjct: 13 VTLSNGVKMPQFGLGVWQSPAGEVTEN----AVKWALCAGYRHIDTAAIYKNEESVGAGL 68 Query: 66 RSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPG 125 R+ V RED+F T+KLW T + A E S +KL +DY+DLYL+H+P G Sbjct: 69 RAS----GVPREDVFITTKLWNTEQGYESTLAAFEESRQKLGVDYIDLYLIHWPR----G 120 Query: 126 ETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYK 185 + L K+ GK D+ W E+ ++IGVSNF+ LE +L Sbjct: 121 KDILSKE--GKKYLDS------WRAFEQLYKEKKVRAIGVSNFHIHHLEDVLAM--CTVT 170 Query: 186 PVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALA 245 P+ NQVE HP NQ+ L FC +K I + A S LG + LL +P+L A+ Sbjct: 171 PMVNQVELHPLNNQADLRAFCDAKQIKVEAWSPLGQGK-----------LLSNPILSAIG 219 Query: 246 KKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRY 305 K+ +T A + LR+ +Q+ ++ + KS + +RI EN +F+F+L +ED+ +D LN N RY Sbjct: 220 AKYNKTAAQVILRWNIQKNLITIPKSVHRERIEENADIFDFELGAEDVMSIDALNTNSRY 279 >4GIE-A nrPDB Length = 290 Score = 184 bits (468), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 109/304 (35%), Positives = 165/304 (54%), Gaps = 36/304 (11%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 M+ Y V L++ MP LG G + + + AIEAG+RHID+AY+Y+NE Sbjct: 9 MNCNYNCVTLHNSVRMPQLGLGVWRAQDGAE--TANAVRWAIEAGYRHIDTAYIYSNERG 66 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 VG IR + V RE+++ T+K+W + + A E S + L L+Y+DLYL+H+P Sbjct: 67 VGQGIR----ESGVPREEVWVTTKVWNSDQGYEKTLAAFERSRELLGLEYIDLYLIHWP- 121 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 GK F VD TW+ +EK + ++IGVSNF L + Sbjct: 122 --------------GKKKF--VD---TWKALEKLYEEKKVRAIGVSNFEPHHLTELFKS- 161 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 K +P+ NQVE HP Q L +FCK +I + A S LG+ +L++ V Sbjct: 162 -CKIRPMVNQVELHPLFQQRTLREFCKQHNIAITAWSPLGS--------GEEAGILKNHV 212 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 L +AKKH ++PA + +R+ +Q G+V + KS N+ RI+EN V++F+LT E+M+ +D LN Sbjct: 213 LGEIAKKHNKSPAQVVIRWDIQHGIVTIPKSTNKGRIQENFNVWDFKLTEEEMRQIDELN 272 Query: 301 RNYR 304 + R Sbjct: 273 EDKR 276 >3KRB-A nrPDB Length = 334 Score = 181 bits (460), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 111/311 (35%), Positives = 167/311 (53%), Gaps = 25/311 (8%) Query: 14 HFMPVLGFGTY-APPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKIADG 72 + P LGFGT+ APPE + AVE A+ G+RHID AY+Y NEE +G A D Sbjct: 23 QYPPRLGFGTWQAPPEAVQT-AVET---ALMTGYRHIDCAYVYQNEEAIGRAFGKIFKDA 78 Query: 73 S--VKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETP-- 128 S +KRED++ TSKLW +P++V+ + ++ LQ+DY+DL+L+H+P+A + Sbjct: 79 SSGIKREDVWITSKLWNYNHRPELVREQCKKTMSDLQVDYLDLFLVHWPLAFVRNDVGDL 138 Query: 129 LPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVC 188 PKD G+ + + V L+ TW ME+ + GL K IGVSN+ L +LN K KP+ Sbjct: 139 FPKDAEGRAMLEKVPLADTWRAMEQLVEEGLVKHIGVSNYTVPLLADLLNY--AKIKPLV 196 Query: 189 NQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSP------VLLEDPVLC 242 NQ+E HP+ + FC I + A+S +G + DP P V+LE L Sbjct: 197 NQIEIHPWHPNDATVKFCLDNGIGVTAYSPMGGS----YADPRDPSGTQKNVILECKTLK 252 Query: 243 ALAKKHKQTPALIALRYQLQRGVV----VLAKSYNEQRIRENIQVFEFQLTSEDMKVLDG 298 A+A +P +AL + +++ V+ KS RI N + E QL+ +DM ++ Sbjct: 253 AIADAKGTSPHCVALAWHVKKWNTSMYSVIPKSQTPARIEANFKCTEVQLSDDDMDAINN 312 Query: 299 LNRNYRYVVMD 309 ++ N R D Sbjct: 313 IHLNKRIRFCD 323 >1VP5-A nrPDB Length = 298 Score = 175 bits (443), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 99/297 (33%), Positives = 166/297 (55%), Gaps = 37/297 (12%) Query: 7 RVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIR 66 +V LN+G MP+LG+G + ++P + E AI+ G+R ID+A Y NEE VG AI+ Sbjct: 17 KVTLNNGVEMPILGYGVF---QIPPEKTEECVYEAIKVGYRLIDTAASYMNEEGVGRAIK 73 Query: 67 SKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE 126 I +G V+RE++F T+KLW + + + A E SLKKLQL+Y+DLYL+H P Sbjct: 74 RAIDEGIVRREELFVTTKLWVSDVGYESTKKAFEKSLKKLQLEYIDLYLIHQPFG----- 128 Query: 127 TPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNC-RQLEMILNKPGLKYK 185 D+ W+ ME+ GL ++IGVSNF R ++++++ + Sbjct: 129 ----------------DVHCAWKAMEEMYKDGLVRAIGVSNFYPDRLMDLMVHH---EIV 169 Query: 186 PVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALA 245 P NQ+E HP+ + + ++F ++ +I A R + ++ VL ++A Sbjct: 170 PAVNQIEIHPFYQRQEEIEFMRNYNIQPEAWGPFAEGRKN---------IFQNGVLRSIA 220 Query: 246 KKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRN 302 +K+ +T A + LR+ Q+G+V + K+ +R++ENI +F+F+LT EDM+ + L+ Sbjct: 221 EKYGKTVAQVILRWLTQKGIVAIPKTVRRERMKENISIFDFELTQEDMEKIATLDEG 277 >3D3F-A nrPDB Length = 275 Score = 168 bits (425), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 115/297 (38%), Positives = 162/297 (54%), Gaps = 39/297 (13%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 V+L++G MP G G + N A E K AI+ G+R ID+A +Y NEE VG+ I+ Sbjct: 8 VKLHNGVEMPWFGLGVFKVEN--GNEATESVKAAIKNGYRSIDTAAIYKNEEGVGIGIK- 64 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 + V RE++F TSK+W + A E SL++LQLDY+DLYL+H+P Sbjct: 65 ---ESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWP-------- 113 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187 GK + TW +EK G ++IGVSNF LE +L +K P+ Sbjct: 114 -------GKDKY-----KDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIK--PM 159 Query: 188 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 247 NQVE HP L Q +L D+CK + I L A S L + LL++ VL +A+K Sbjct: 160 VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQ-----------LLDNEVLTQIAEK 208 Query: 248 HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYR 304 H ++ A + LR+ LQ GVV + KS E RI EN +F+F+L+ EDM +D LN++ R Sbjct: 209 HNKSVAQVILRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDER 265 >4IJC-A nrPDB Length = 344 Score = 164 bits (415), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 113/333 (33%), Positives = 179/333 (53%), Gaps = 32/333 (9%) Query: 1 MDPKYQRV--ELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNE 58 + PK + LN+G +P LG GT P E + K AI+AG+RHID+A+ Y E Sbjct: 16 LHPKTTEIYFSLNNGVRIPALGLGTANPHE-KLAETKQAVKAAIKAGYRHIDTAWAYETE 74 Query: 59 EQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHF 118 VG AI+ + DGS+KRED+F T+K+W + V +L SLK L L+YVDL L H+ Sbjct: 75 PFVGEAIKELLEDGSIKREDLFITTKVWPVLWDE--VDRSLNESLKALGLEYVDLLLQHW 132 Query: 119 PMALKPGETP--------LPKDENGKVIFDT-VDLSATWEVMEKC---KDAGLAKSIGVS 166 P+ + + P P D++GK ++ D T++ +EK + ++IGVS Sbjct: 133 PLCFEKIKDPKGISGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDPNDHRVRAIGVS 192 Query: 167 NFNCRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKL 226 NF+ LE ++ + + KP NQVE HP+L Q +L FC DI+L A+S LG+ Sbjct: 193 NFSIEYLERLIKE--CRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGA-- 248 Query: 227 WVDPNSPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEF 286 PN L+ P++ LA+K+ T + + Y +++G +V+ +S N RI +I+ Sbjct: 249 ---PN----LKIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEF--A 299 Query: 287 QLTSEDMKVLDGLNRNY--RYVVMDFLMDHPDY 317 LT ++++ L+ Y R++ F P++ Sbjct: 300 SLTKDELQELNDFGEKYPVRFIDEPFAAILPEF 332 >1A80-A nrPDB Length = 277 Score = 163 bits (413), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 106/291 (36%), Positives = 151/291 (51%), Gaps = 36/291 (12%) Query: 10 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKI 69 LNDG+ +P LG+G + P RAVE A+E G+RHID+A +Y NEE VG AI + Sbjct: 7 LNDGNSIPQLGYGVFKVPPADTQRAVEE---ALEVGYRHIDTAAIYGNEEGVGAAIAAS- 62 Query: 70 ADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPL 129 + R+D+F T+KLW A+ SL KL LD VDLYL+H+P Sbjct: 63 ---GIARDDLFITTKLWNDRHDGDEPAAAIAESLAKLALDQVDLYLVHWPT--------- 110 Query: 130 PKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCN 189 P +N WE M + + AGL +SIGVSN LE I+ G+ P N Sbjct: 111 PAADN---------YVHAWEKMIELRAAGLTRSIGVSNHLVPHLERIVAATGVV--PAVN 159 Query: 190 QVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHK 249 Q+E HP Q ++ D+ + D+ + + LG ++ L +PV A A H Sbjct: 160 QIELHPAYQQREITDWAAAHDVKIESWGPLGQGKYDL--------FGAEPV-TAAAAAHG 210 Query: 250 QTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 +TPA LR+ LQ+G VV KS +R+ EN+ VF+F LT ++ +D ++ Sbjct: 211 KTPAQAVLRWHLQKGFVVFPKSVRRERLEENLDVFDFDLTDTEIAAIDAMD 261 >4OTK-A nrPDB Length = 318 Score = 161 bits (408), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 109/298 (36%), Positives = 150/298 (50%), Gaps = 40/298 (13%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 + LND H MPVLG G + RAV A+E G R ID+AY Y NE VG AI Sbjct: 49 ITLNDEHTMPVLGLGVAELSDDETERAVSA---ALEIGCRLIDTAYAYGNEAAVGRAI-- 103 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 A V RE++F T+KL Q A +SL +L LDYVDLYL+H+P Sbjct: 104 --AASGVAREELFVTTKLATPDQGFTRSQEACRASLDRLGLDYVDLYLIHWPAP------ 155 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKY-KP 186 P+ K VD W M + + G A+SIGVSNF +E +++ L + P Sbjct: 156 PVGK---------YVD---AWGGMIQSRGEGHARSIGVSNFTAENIENLID---LTFVTP 200 Query: 187 VCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAK 246 NQ+E HP LNQ +L +V ++ L R LL++P + ++A Sbjct: 201 AVNQIELHPLLNQDELRKANAQHTVVTQSYCPLALGR-----------LLDNPTVTSIAS 249 Query: 247 KHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYR 304 ++ +TPA + LR+ LQ G V+ +S +RI N VF+F+L +E M L GLN R Sbjct: 250 EYVKTPAQVLLRWNLQLGNAVVVRSARPERIASNFDVFDFELAAEHMDALGGLNDGTR 307 >4MHB-A nrPDB Length = 297 Score = 158 bits (400), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 105/304 (34%), Positives = 157/304 (51%), Gaps = 48/304 (15%) Query: 2 DPKYQRVELNDGHFMPVLGFGTYAPPEVPR-NRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 D Q V+LN+G MP+LGFG + RAV AIE G+R ID+A Y NE Q Sbjct: 12 DNVMQTVKLNNGIAMPLLGFGVFQMTNTAECERAV---IDAIETGYRLIDTAASYQNETQ 68 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWC--TFFQPQMVQPALESSLKKLQLDYVDLYLLHF 118 VG A++ + R+++F T+KLW T+++ Q E SL +LQLDYVDLYL+H Sbjct: 69 VGNALKLS----GIARDELFITTKLWLQDTYYEGAKAQ--FERSLNRLQLDYVDLYLIHQ 122 Query: 119 PMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLE--MI 176 P D+ W ME+ AG ++IGVSNF+ +L M Sbjct: 123 PYG---------------------DVHGAWRAMEELHQAGKIRAIGVSNFHPDRLADLMA 161 Query: 177 LNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLL 236 NK P NQ+E +P+ Q + + +S+ I A + R+ L Sbjct: 162 FNK----IIPAVNQIEVNPFNQQLHAVPWMQSRGIQPEAWAPFAEGRNGL---------F 208 Query: 237 EDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVL 296 ++PVL A+ +K+ ++ + LR+ QRG+V LAKS + R+ ENI + +F+L++EDM + Sbjct: 209 QNPVLTAIGEKYGKSVGQVVLRWIFQRGIVSLAKSVRKGRMEENINILDFELSAEDMLQI 268 Query: 297 DGLN 300 L+ Sbjct: 269 AALD 272 >3UP8-A nrPDB Length = 298 Score = 157 bits (398), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 97/302 (32%), Positives = 161/302 (53%), Gaps = 49/302 (16%) Query: 11 NDGHFMPVLGFGTYAPPEVPRNRAVEVTKL---AIEAGFRHIDSAYLYNNEEQVGLAIRS 67 ++G +P LGFGT+ R EV ++ A++ GFRH+D+A +Y NE +VG AI+ Sbjct: 29 SNGANIPALGFGTF------RMSGAEVLRILPQALKLGFRHVDTAQIYGNEAEVGEAIQK 82 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 + R D+F T+K+W ++ +++ SL+KL+ D+VDL LLH+P + P Sbjct: 83 S----GIPRADVFLTTKVWVDNYRHDAFIASVDESLRKLRTDHVDLLLLHWPGSDVP--- 135 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187 ++ + + ++AG + IG+SNFN Q+E L P+ Sbjct: 136 ----------------MAERIGALNEVRNAGKVRHIGISNFNTTQME---EAARLSDAPI 176 Query: 188 C-NQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAK 246 NQVE HPYL+Q+K+L + + L ++ A+ + + DP+L + Sbjct: 177 ATNQVEYHPYLDQTKVLQTARRLGMSLTSYYAMANGK-----------VPADPLLTEIGG 225 Query: 247 KHKQTPALIALRYQL-QRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNR-NYR 304 +H +T A +ALR+ + Q+ V+VL+K+ E R++EN +F+F LT E+M + L R N R Sbjct: 226 RHGKTAAQVALRWLVQQQDVIVLSKTATEARLKENFAIFDFALTREEMAAVRELARPNGR 285 Query: 305 YV 306 V Sbjct: 286 IV 287 >1MZR-A nrPDB Length = 296 Score = 155 bits (392), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 99/297 (33%), Positives = 155/297 (52%), Gaps = 38/297 (12%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 ++L DG+ MP LG G + + + + A+E G+R ID+A Y NEE VG A++ Sbjct: 28 IKLQDGNVMPQLGLGVW---QASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK- 83 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 + SV RE++F T+KLW + + AL SLKKLQLDY+DLYL+H+P+ Sbjct: 84 ---NASVNREELFITTKLWND--DHKRPREALLDSLKKLQLDYIDLYLMHWPVP------ 132 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187 I V+ W+ M + + GL KSIGV NF L+ ++++ G+ PV Sbjct: 133 ---------AIDHYVE---AWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PV 178 Query: 188 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 247 NQ+E HP + Q +L + + I + S L + + V+ LA K Sbjct: 179 INQIELHPLMQQRQLHAWNATHKIQTESWSPLAQ---------GGKGVFDQKVIRDLADK 229 Query: 248 HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYR 304 + +TPA I +R+ L G+VV+ KS RI EN V++F+L +++ + L++ R Sbjct: 230 YGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 286 >3WG6-A nrPDB Length = 307 Score = 135 bits (341), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 91/302 (30%), Positives = 157/302 (51%), Gaps = 42/302 (13%) Query: 6 QRVELNDGHFMPVLGFGTYAPPEVPRN------RAVEVTKLAIEAGFRHIDSAYLYNNEE 59 + +L++G+ +P + FGT R + + +LA+ +GFRHID A +Y + Sbjct: 9 KEFKLSNGNKIPAVAFGT-GTKYFKRGHNDLDKQLIGTLELALRSGFRHIDGAEIYGTNK 67 Query: 60 QVGLAIRSKIADGSVKREDIFYTSKLWCT-------FFQPQMVQPALESSLKKLQLDYVD 112 ++G+A+++ + R+D+F T K + Q AL++ L+ L L+YVD Sbjct: 68 EIGIALKNV----GLNRKDVFITDKYNSGNHTYDGKHSKHQNPYNALKADLEDLGLEYVD 123 Query: 113 LYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQ 172 LYL+HFP + + +G DL W +E+ K+ GLA++IGVSNF Sbjct: 124 LYLIHFPY--------ISEKSHG------FDLVEAWRYLERAKNEGLARNIGVSNFTIEN 169 Query: 173 LEMILNKPGLKYKPVCNQVECHPYLNQSK--LLDFCKSKDIVLVAHSALGTQRHKLWVDP 230 L+ IL+ PV NQ+E YL ++++ + + I++ A+ LG + Sbjct: 170 LKSILD-ANTDSIPVVNQIEFSAYLQDQTPGIVEYSQQQGILIEAYGPLGP------ITQ 222 Query: 231 NSPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTS 290 P L D VL L++K+K+ I LR+ LQRG++ + + E+RI + +++F+F+L Sbjct: 223 GRPGPL-DKVLSKLSEKYKRNEGQILLRWVLQRGILPITTTSKEERINDVLEIFDFELDK 281 Query: 291 ED 292 ED Sbjct: 282 ED 283 >4H8N-A nrPDB Length = 310 Score = 132 bits (333), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 91/268 (33%), Positives = 147/268 (54%), Gaps = 31/268 (11%) Query: 40 LAIEAGFRHIDSAYLYNNEEQVGLAIRSKIADGSVKREDIFYTSKL---WCTFFQ-PQMV 95 L ++ GFRHID+A YN +++VG A++ V REDI+ T+K W + + Sbjct: 51 LGLKLGFRHIDTAEAYNTQKEVGEALKRT----DVPREDIWVTTKYSPGWGSIKAYSKSP 106 Query: 96 QPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCK 155 +++ +L +L +DYVDL+L+H P + +G L WE + + K Sbjct: 107 SDSIDKALAQLGVDYVDLFLIHSPFFTT-------EQTHGYT------LEQAWEALVEAK 153 Query: 156 DAGLAKSIGVSNFNCRQLE-MILNKPGLKYKPVCNQVECHPYL-NQSK-LLDFCKSKDIV 212 AG + IG+SN LE + P +Y PV NQ+E HP+L NQSK ++ FC+ I+ Sbjct: 154 KAGKVREIGISNAAIPHLEKLFAASPSPEYYPVVNQIEFHPFLQNQSKNIVRFCQEHGIL 213 Query: 213 LVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSY 272 + A S L V+ N+ L E L LA+K+K+T A + LRY LQRG++ + S Sbjct: 214 VEAFSPLAPLAR---VETNA--LAE--TLKRLAEKYKKTEAQVLLRYTLQRGILPVTTSS 266 Query: 273 NEQRIRENIQVFEFQLTSEDMKVLDGLN 300 E R++E++ +F+F+LT E++ ++ + Sbjct: 267 KESRLKESLNLFDFELTDEEVNEINKIG 294 >1PZ1-A nrPDB Length = 333 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 51/172 (29%), Positives = 82/172 (47%), Gaps = 40/172 (23%) Query: 19 LGFGTYAPPEV-----PRNRAVEVTKLAIEAGFRHIDSAYLYN---NEEQVGLAIRSKIA 70 +G GT+A ++E + A++ G ID+A Y +EE VG AI+ + Sbjct: 16 IGLGTWAIGGTMWGGTDEKTSIETIRAALDQGITLIDTAPAYGFGQSEEIVGKAIKEYM- 74 Query: 71 DGSVKREDIFYTSKLWCTFFQPQMVQPA--------LESSLKKLQLDYVDLYLLHFPMAL 122 KR+ + +K + Q+ + A +E+SLK+LQ DY+DLY +H+P L Sbjct: 75 ----KRDQVILATKTALDWKNNQLFRHANRARIVEEVENSLKRLQTDYIDLYQVHWPDPL 130 Query: 123 KPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLE 174 P + T EVM++ DAG ++IGVSNF+ Q++ Sbjct: 131 VP-------------------IEETAEVMKELYDAGKIRAIGVSNFSIEQMD 163 >1PYF-A nrPDB Length = 312 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 53/181 (29%), Positives = 81/181 (44%), Gaps = 43/181 (23%) Query: 19 LGFGTYAP------PEVPRNRAVEVTKLAIEAGFRHIDSAYLYN---NEEQVGLAIRSKI 69 +G GT A P + E+ + AI G +D+AY+Y +EE +G +R Sbjct: 16 IGLGTNAVGGHNLYPNLNEETGKELVREAIRNGVTMLDTAYIYGIGRSEELIGEVLRE-- 73 Query: 70 ADGSVKREDIFYTSKL--------WCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMA 121 RED+ +K + P ++ +++ SLK+L DY+DL+ +HFP Sbjct: 74 ----FNREDVVIATKAAHRKQGNDFVFDNSPDFLKKSVDESLKRLNTDYIDLFYIHFP-- 127 Query: 122 LKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPG 181 + PKDE + + K AG +SIGVSNF+ QL+ NK G Sbjct: 128 ----DEHTPKDE-------------AVNALNEMKKAGKIRSIGVSNFSLEQLKEA-NKDG 169 Query: 182 L 182 L Sbjct: 170 L 170 >1GVE-A nrPDB Length = 327 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 41/148 (27%), Positives = 68/148 (45%), Gaps = 12/148 (8%) Query: 42 IEAGFRHIDSAYLYNN--EEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPAL 99 ++ G ID+A++Y N E + + + K + + ++ +P V+ L Sbjct: 32 LQRGHTEIDTAFVYANGQSETILGDLGLGLGRSGCKVKIATKAAPMFGKTLKPADVRFQL 91 Query: 100 ESSLKKLQLDYVDLYLLHFPMALKPGETPLPK----DENGKVIFDTVDLSATWEVMEKC- 154 E+SLK+LQ VDL+ LHFP P E L + GK + + +WEV E C Sbjct: 92 ETSLKRLQCPRVDLFYLHFPDHGTPIEETLQACHQLHQEGKFVELGLSNYVSWEVAEICT 151 Query: 155 ---KDAGLAKSI--GVSNFNCRQLEMIL 177 K+ + ++ G+ N RQ+E L Sbjct: 152 LCKKNGWIMPTVYQGMYNAITRQVETEL 179 >2CLP-A nrPDB Length = 347 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 39/137 (28%), Positives = 62/137 (45%), Gaps = 9/137 (6%) Query: 34 AVEVTKLAIEAGFRHIDSAYLYN--NEEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQ 91 + VT+ +E G ID+A++Y+ E + + ++ + + L+ + Sbjct: 44 SAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLK 103 Query: 92 PQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPK----DENGKVIFDTVDLSAT 147 P ++ LE+SLK+LQ VDL+ LH P P E L + GK + + A Sbjct: 104 PDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAA 163 Query: 148 WEVMEKCKDAGLAKSIG 164 WEV E C L KS G Sbjct: 164 WEVAEICT---LCKSNG 177 >2BP1-A nrPDB Length = 360 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 44/151 (29%), Positives = 66/151 (43%), Gaps = 18/151 (11%) Query: 42 IEAGFRHIDSAYLYNNEEQVGLAIRSKIADGSVK-REDIFYTSKLW-CTFFQPQMVQPAL 99 +E G +D+A++Y++ + + + G R I + W +P V+ L Sbjct: 65 LERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQL 124 Query: 100 ESSLKKLQLDYVDLYLLHFPMALKPGETPLPK----DENGKVIFDTVDLSATWEVMEKCK 155 E+SLK+LQ VDL+ LH P P E L + GK + + A+WEV E C Sbjct: 125 ETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICT 184 Query: 156 DAGLAKS---------IGVSNFNCRQLEMIL 177 L KS G+ N RQ+E L Sbjct: 185 ---LCKSNGWILPTVYQGMYNATTRQVETEL 212 >1LQA-A nrPDB Length = 346 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 56/244 (22%), Positives = 108/244 (44%), Gaps = 43/244 (17%) Query: 95 VQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFD------TVDLSATW 148 ++ AL SLK+LQ DY+DLY +H+P P + GK+ + V L T Sbjct: 110 IREALHDSLKRLQTDYLDLYQVHWPQR--------PTNCFGKLGYSWTDSAPAVSLLDTL 161 Query: 149 EVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECHPY--LNQS---KLL 203 + + + + AG + IGVSN + L+ P ++ +PY LN+S L Sbjct: 162 DALAEYQRAGKIRYIGVSNETAFGVMRYLHLADKHDLPRIVTIQ-NPYSLLNRSFEVGLA 220 Query: 204 DFCKSKDIVLVAHSAL--GTQRHKLWVDPNSPVLLEDPVLCA------------------ 243 + + + + L+A+S L GT K +++ P + + Sbjct: 221 EVSQYEGVELLAYSCLGFGTLTGK-YLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVD 279 Query: 244 LAKKHKQTPALIALRYQLQRGVV--VLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNR 301 +A++H PA +AL + ++ V L + +++ NI+ +L+ + + ++ +++ Sbjct: 280 IARRHGLDPAQMALAFVRRQPFVASTLLGATTMDQLKTNIESLHLELSEDVLAEIEAVHQ 339 Query: 302 NYRY 305 Y Y Sbjct: 340 VYTY 343 >2C91-A nrPDB Length = 338 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 44/154 (28%), Positives = 67/154 (43%), Gaps = 24/154 (15%) Query: 42 IEAGFRHIDSAYLYNNEEQVGLAIRSKIA----DGSVKREDIFYTSKLW-CTFFQPQMVQ 96 +E G +D+A++Y + + + + D +VK I + W +P ++ Sbjct: 43 LERGHSELDTAFMYCDGQSENILGGLGLGLGSGDCTVK---IATKANPWEGKSLKPDSIR 99 Query: 97 PALESSLKKLQLDYVDLYLLHFPMALKPGETPLPK----DENGKVIFDTVDLSATWEVME 152 LE+SLK+LQ VDL+ LH P P E L + GK + + A+WEV E Sbjct: 100 SQLETSLKRLQCPRVDLFYLHAPDHSTPVEETLCACHQLHQEGKFVELGLSNYASWEVAE 159 Query: 153 KCKDAGLAKS---------IGVSNFNCRQLEMIL 177 C L KS G+ N RQ+E L Sbjct: 160 ICT---LCKSNGWILPTVYQGMYNATTRQVEAEL 190 >4R9O-A nrPDB Length = 301 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 33/105 (31%), Positives = 48/105 (45%), Gaps = 22/105 (20%) Query: 100 ESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGL 159 E SLK L DY+D+ L+H P PL D D++ E + +G Sbjct: 114 EQSLKNLATDYLDMLLIHRP-------DPL---------MDADDVA---EAFQHLHQSGK 154 Query: 160 AKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLD 204 + GVSNF Q ++ ++ L + NQVE P ++Q LLD Sbjct: 155 VRHFGVSNFTPAQFTLLQSR--LPFTLATNQVEISP-VHQPLLLD 196 >4EXA-A nrPDB Length = 292 Score = 36.2 bits (82), Expect = 0.022, Method: Compositional matrix adjust. Identities = 30/99 (30%), Positives = 50/99 (50%), Gaps = 17/99 (17%) Query: 29 VPRNR-AVEVTKLAIEAGFRHIDSAYLYN-NEEQVGLAIRSKIADGSVKREDIFYTSKLW 86 +P +R A ++ LA + G ID+A Y +EE++G +R + RE SK+ Sbjct: 66 IPDDREAADLLALARDLGINLIDTAPAYGRSEERLGPLLRGQ-------REHWVIVSKVG 118 Query: 87 CTFFQPQMV--------QPALESSLKKLQLDYVDLYLLH 117 F Q V + ++E SLK+L+ D ++L L+H Sbjct: 119 EEFVDGQSVFDFSAAHTRRSVERSLKRLETDRIELVLVH 157 >3N6Q-A nrPDB Length = 346 Score = 35.0 bits (79), Expect = 0.045, Method: Compositional matrix adjust. Identities = 63/312 (20%), Positives = 129/312 (41%), Gaps = 74/312 (23%) Query: 37 VTKLAIEAGFRHIDSAYLY-----NNEEQVGLAIRSKIADGSVKREDIFYTSK----LW- 86 + + A + G H D A Y + EE G +R A R+++ ++K +W Sbjct: 48 ILRKAFDLGITHFDLANNYGPPPGSAEENFGRLLREDFA---AYRDELIISTKAGYDMWP 104 Query: 87 ---CTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVD 143 + + + +L+ SLK++ L+YVD++ H DEN Sbjct: 105 GPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSH------------RVDEN-------TP 145 Query: 144 LSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNK------PGLKYKPVCNQVECHPYL 197 + T + +G A +G+S+++ + + ++ P L ++P N + + ++ Sbjct: 146 MEETASALAHAVQSGKALYVGISSYSPERTQKMVELLREWKIPLLIHQPSYNLL--NRWV 203 Query: 198 NQSKLLDFCKSKDIVLVAHSALGT------------QRHKLWVDPN-----SPVLLEDPV 240 ++S LLD ++ + +A + L Q ++ + N +P +L + Sbjct: 204 DKSGLLDTLQNNGVGCIAFTPLAQGLLTGKYLNGIPQDSRMHREGNKVRGLTPKMLTEAN 263 Query: 241 LCAL------AKKHKQTPALIALRYQLQ--RGVVVLAKSYNEQRIRENIQVFEF------ 286 L +L A++ Q+ A +AL + L+ R VL + +++ EN+Q Sbjct: 264 LNSLRLLNEMAQQRGQSMAQMALSWLLKDDRVTSVLIGASRAEQLEENVQALNNLTFSTK 323 Query: 287 QLTSEDMKVLDG 298 +L D + DG Sbjct: 324 ELAQIDQHIADG 335 >1OG6-A nrPDB Length = 298 Score = 34.7 bits (78), Expect = 0.058, Method: Compositional matrix adjust. Identities = 30/105 (28%), Positives = 45/105 (42%), Gaps = 22/105 (20%) Query: 100 ESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGL 159 E SL L D++DL L+H P PL +D + + +G Sbjct: 111 EQSLINLATDHLDLLLIHRP-------DPL------------MDADEVADAFKHLHQSGK 151 Query: 160 AKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLD 204 + GVSNF Q ++ ++ L + NQVE P ++Q LLD Sbjct: 152 VRHFGVSNFTPAQFALLQSR--LPFTLATNQVEISP-VHQPLLLD 193 >3EB3-A nrPDB Length = 327 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 43/204 (21%), Positives = 80/204 (39%), Gaps = 47/204 (23%) Query: 12 DGHFMPVLGFGTYAP--PEVPRNRAVEVTKLAIEAGFRHIDSAYLY---NNEEQVGLAIR 66 G + LG GT+ ++ A + LA + G D+A +Y E +G I+ Sbjct: 11 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 70 Query: 67 SKIADGSVKREDIFYTSKLWCTF-------FQPQMVQPALESSLKKLQLDYVDLYLLHFP 119 K +R + T+K++ + + L++SL++LQL+YVD+ + P Sbjct: 71 KK----GWRRSSLVITTKIFAGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP 126 Query: 120 MALKPGETPLPKDENGKVIFDTVDL-------SATWEVMEKCKDAGLAKSIGVSNFNCRQ 172 + P +E + + ++ ++ W ME + +A RQ Sbjct: 127 ------DPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVA----------RQ 170 Query: 173 LEMILNKPGLKYKPVCNQVECHPY 196 +I P+C Q E H + Sbjct: 171 FNLI--------PPICEQAEYHMF 186 >4V4N-AM nrPDB Length = 194 Score = 32.3 bits (72), Expect = 0.26, Method: Compositional matrix adjust. Identities = 16/58 (27%), Positives = 29/58 (50%) Query: 228 VDPNSPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFE 285 VDP+ PV+ DP + +A KH + L ++G + K +++R +I+ E Sbjct: 133 VDPHHPVIKSDPKIAWIALKHHKGRVFRGLTSAGKKGRGLRNKGKGAEKVRPSIRANE 190 >5LG6-A nrPDB Length = 968 Score = 31.6 bits (70), Expect = 0.45, Method: Compositional matrix adjust. Identities = 38/148 (25%), Positives = 68/148 (45%), Gaps = 15/148 (10%) Query: 13 GHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEE--QVGLA------ 64 GH + + G G PE+ R VE+T+ + + ++Y E Q LA Sbjct: 111 GHMVVLRGVGDSQVPEIDRTELVELTEYLVVHLKGSLQPGHMYEMESEFQGELADDLAGF 170 Query: 65 IRSKIADGSVKREDIFYTSKLWCTFFQ---PQMVQPALESSLKKLQLDYVDLYLLHFPMA 121 RS+ +G+VK+ + T+++ T + P +PA++++ + +L L M Sbjct: 171 YRSEYMEGNVKK--VLATTQMQSTDARKSFPCFDEPAMKATFNITLIHPNNLTALS-NMP 227 Query: 122 LKPGETPLPKDENGKVI-FDTVDLSATW 148 K TPL +D N V F+T + +T+ Sbjct: 228 PKGSSTPLAEDPNWSVTEFETTPVMSTY 255 >5LHD-A nrPDB Length = 950 Score = 31.6 bits (70), Expect = 0.47, Method: Compositional matrix adjust. Identities = 37/139 (26%), Positives = 64/139 (46%), Gaps = 14/139 (10%) Query: 10 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIE--AGFRHIDSAYLYNNEEQVGLA--- 64 L+ GH + + G G PP++ + VE T+ + G DS Y ++E + LA Sbjct: 114 LSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDL 173 Query: 65 ---IRSKIADGSVKREDIFYTSKLWCTFFQ---PQMVQPALESSLKKLQLDYVDLYLLHF 118 RS+ +G+V++ + T+++ + P +PA+++ + DL L Sbjct: 174 AGFYRSEYMEGNVRK--VVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALS- 230 Query: 119 PMALKPGETPLPKDENGKV 137 M K TPLP+D N V Sbjct: 231 NMLPKGPSTPLPEDPNWNV 249 >1V6C-A nrPDB Length = 441 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 15/50 (30%), Positives = 27/50 (54%) Query: 187 VCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLL 236 V NQ +P +N +K +K I++ ++SAL ++ VD NS + + Sbjct: 282 VGNQGSSYPEINSTKACKTAGAKGIIVYSNSALPGLQNPFLVDANSDITV 331 >5F7C-A nrPDB Length = 761 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 32/78 (41%), Gaps = 22/78 (28%) Query: 35 VEVTKLAIEAGF----------------RHIDSAYLYNNEEQVGLAIRSKIADGSVKRED 78 +E +KLA+E+G+ HID Y + N+ V + S+ R D Sbjct: 619 IEQSKLAVESGWPLLQALILHHPEDKLCWHIDDEYYFGNDFLVAPVMNSE------NRRD 672 Query: 79 IFYTSKLWCTFFQPQMVQ 96 I+ W FF + +Q Sbjct: 673 IYLPEGQWVNFFTGERLQ 690 >2RCY-A nrPDB Length = 262 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 13/44 (29%), Positives = 24/44 (54%), Gaps = 1/44 (2%) Query: 195 PYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLED 238 PYL+ L+ C +I + +G++ +WV PN+P L+ + Sbjct: 80 PYLSSKLLISICGGLNIGKL-EEMVGSENKIVWVMPNTPCLVGE 122 >6GEJ-U nrPDB Length = 471 Score = 29.3 bits (64), Expect = 2.1, Method: Compositional matrix adjust. Identities = 16/51 (31%), Positives = 29/51 (56%), Gaps = 6/51 (11%) Query: 261 LQRGVVVLAKSYNEQRIRENIQVF----EFQLTSEDMKVL--DGLNRNYRY 305 L R +++ KSYNEQ I+ + + E +L+S+ + +L G+ + RY Sbjct: 348 LDRSIIITTKSYNEQEIKTILSIRAQEEEVELSSDALDLLTKTGVETSLRY 398 >3WVG-A nrPDB Length = 300 Score = 28.5 bits (62), Expect = 4.2, Method: Compositional matrix adjust. Identities = 33/124 (26%), Positives = 55/124 (44%), Gaps = 6/124 (4%) Query: 173 LEMILNKPGLKYKPVCNQVECHPY-LNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPN 231 L +I N ++K N + Y LN++++++ +S I+ A TQ KL+ Sbjct: 10 LSLIENLTNQEFKQATNSLISFIYKLNRNEVIELVRSIGILPEAIKPSSTQ-EKLFSKAG 68 Query: 232 SPVLLEDPVLCALAKK----HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQ 287 VL + L L K +IAL + G+V AKS+ R +N + F+ + Sbjct: 69 DIVLAKAFQLLNLNSKPLEQRGNAGDVIALSKEFNYGLVADAKSFRLSRTAKNQKDFKVK 128 Query: 288 LTSE 291 SE Sbjct: 129 ALSE 132 >4EO5-A nrPDB Length = 169 Score = 27.7 bits (60), Expect = 6.2, Method: Compositional matrix adjust. Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 9/88 (10%) Query: 196 YLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKQTPALI 255 Y+ S+ LD + D +LV +G + DP S L+ L ++ T L+ Sbjct: 44 YVGSSRSLDHDQELDSILVGPVPVGVNKFVFSADPPSAELIPASELVSV------TVILL 97 Query: 256 ALRYQLQRGVVV---LAKSYNEQRIREN 280 + Y + V V + Y+E+ +REN Sbjct: 98 SCSYDGREFVRVGYYVNNEYDEEELREN 125 >4F3S-A nrPDB Length = 255 Score = 27.7 bits (60), Expect = 6.8, Method: Compositional matrix adjust. Identities = 18/60 (30%), Positives = 30/60 (50%), Gaps = 8/60 (13%) Query: 49 IDSAYLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQL 108 I+S Y++ N +Q+G+A + GS R+D LW PQ + ++S +K L Sbjct: 186 IESRYVFKNVDQLGIAFKK----GSPVRDDF----NLWLKEQGPQKISGIVDSWMKAENL 237 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2FVL-A nrPDB 534 e-152 4JQA-A nrPDB 527 e-150 5JM5-A nrPDB 523 e-149 1Q5M-A nrPDB 520 e-148 2HE8-A nrPDB 499 e-142 5UXF-A nrPDB 494 e-140 3G1R-A nrPDB 490 e-139 1AFS-A nrPDB 486 e-138 1ZUA-X nrPDB 479 e-136 3RX4-A nrPDB 455 e-128 2ALR-A nrPDB 454 e-128 4GAC-A nrPDB 452 e-127 1DLA-A nrPDB 451 e-127 1HQT-A nrPDB 450 e-127 1C9W-A nrPDB 446 e-126 1FRB-A nrPDB 442 e-124 3O3R-A nrPDB 435 e-122 4HBK-A nrPDB 423 e-119 1K8C-A nrPDB 390 e-109 3H7U-A nrPDB 388 e-108 5Z6T-A nrPDB 387 e-108 5ZCM-A nrPDB 385 e-107 3WCZ-A nrPDB 384 e-107 5JH1-A nrPDB 382 e-106 3H7R-A nrPDB 370 e-103 1QWK-A nrPDB 368 e-102 4GIE-A nrPDB 368 e-102 1VBJ-A nrPDB 363 e-101 4F40-A nrPDB 359 1e-99 2BGQ-A nrPDB 356 8e-99 3KRB-A nrPDB 351 2e-97 1VP5-A nrPDB 343 8e-95 1MZR-A nrPDB 333 7e-92 4IJC-A nrPDB 330 6e-91 3D3F-A nrPDB 324 3e-89 4MHB-A nrPDB 321 2e-88 4OTK-A nrPDB 307 4e-84 1A80-A nrPDB 299 8e-82 3UP8-A nrPDB 286 9e-78 3WG6-A nrPDB 275 2e-74 4H8N-A nrPDB 268 2e-72 1LQA-A nrPDB 177 5e-45 1PZ1-A nrPDB 163 8e-41 1PYF-A nrPDB 161 3e-40 2CLP-A nrPDB 128 4e-30 1GVE-A nrPDB 127 5e-30 2BP1-A nrPDB 124 5e-29 2C91-A nrPDB 123 7e-29 4R9O-A nrPDB 113 2e-25 Sequences not found previously or not previously below threshold: 3N6Q-A nrPDB 111 4e-25 3EB3-A nrPDB 108 3e-24 1OG6-A nrPDB 102 3e-22 4EXA-A nrPDB 61 9e-10 1T6J-A nrPDB 36 0.022 4EHI-A nrPDB 32 0.36 2PTS-A nrPDB 31 0.58 3VS9-A nrPDB 31 0.75 4FO0-A nrPDB 30 1.4 4Y0A-A nrPDB 30 1.6 5ZF1-A nrPDB 30 1.9 4L1C-A nrPDB 30 2.0 3MMA-A nrPDB 28 4.3 6ET0-A nrPDB 28 6.3 4MKI-B nrPDB 28 7.0 4A2N-B nrPDB 28 7.3 >2FVL-A nrPDB Length = 324 Score = 534 bits (1375), Expect = e-152, Method: Composition-based stats. Identities = 321/323 (99%), Positives = 322/323 (99%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ Sbjct: 2 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 61 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM Sbjct: 62 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 121 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFN RQLEMILNKP Sbjct: 122 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKP 181 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV Sbjct: 182 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 241 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 LCALAKKHK+TPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN Sbjct: 242 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 301 Query: 301 RNYRYVVMDFLMDHPDYPFSDEY 323 RNYRYVVMDFLMDHPDYPFSDEY Sbjct: 302 RNYRYVVMDFLMDHPDYPFSDEY 324 >4JQA-A nrPDB Length = 331 Score = 527 bits (1358), Expect = e-150, Method: Composition-based stats. Identities = 263/323 (81%), Positives = 292/323 (90%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 MD KYQ V+LNDGHFMPVLGFGTYAP EVP+++A+E KLAIEAGF HIDSA++YNNEEQ Sbjct: 1 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ 60 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 VGLAIRSKIADGSVKREDIFYTSKLW +P++V+PALE SLK LQLDYVDLYL+HFP+ Sbjct: 61 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 120 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 ++KPGE +PKDENGK++FDTVDL ATWE MEKCKDAGLAKSIGVSNFN R LEMILNKP Sbjct: 121 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP 180 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 GLKYKPVCNQVECHPY NQ KLLDFCKSKDIVLVA+SALG+ R + WVDPNSPVLLEDPV Sbjct: 181 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 240 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 LCALAKKHK+TPALIALRYQLQRGVVVLAKSYNEQRIR+N+QVFEFQLTSE+MK +DGLN Sbjct: 241 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 300 Query: 301 RNYRYVVMDFLMDHPDYPFSDEY 323 RN RY+ +D P+YPFSDEY Sbjct: 301 RNVRYLTLDIFAGPPNYPFSDEY 323 >5JM5-A nrPDB Length = 332 Score = 523 bits (1347), Expect = e-149, Method: Composition-based stats. Identities = 271/323 (83%), Positives = 294/323 (91%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 MD K Q V+LNDGHFMPVLGFGTYAPPEVPR++A+EVTKLAIEAGFRHIDSA+LYNNEEQ Sbjct: 1 MDSKQQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ 60 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 VGLAIRSKIADGSVKREDIFYTSKLW TF +P++V+PALE+SLKK QLDYVDLYL+H PM Sbjct: 61 VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM 120 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 +LKPGE P DENGKVIFD VDL TWE MEKCKDAGLAKSIGVSNFN RQLEMILNKP Sbjct: 121 SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP 180 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 GLKYKPVCNQVECHPY N+SKLLDFCKSKDIVLVA+SALG+QR K WVDPNSPVLLEDPV Sbjct: 181 GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV 240 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 LCALAKKHK+TPALIALRYQLQRGVVVLAKSYNEQRIR+N+QVFEFQLT+EDMK +DGL+ Sbjct: 241 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD 300 Query: 301 RNYRYVVMDFLMDHPDYPFSDEY 323 RN Y D HP+YP+SDEY Sbjct: 301 RNLHYFNSDSFASHPNYPYSDEY 323 >1Q5M-A nrPDB Length = 322 Score = 520 bits (1340), Expect = e-148, Method: Composition-based stats. Identities = 252/322 (78%), Positives = 290/322 (90%) Query: 2 DPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQV 61 DPK+QRV L+DGHF+PVLGFGTYAP EVP+++A+E TK+AI+AGFRHIDSAY Y NE++V Sbjct: 1 DPKFQRVALSDGHFIPVLGFGTYAPEEVPKSKAMEATKIAIDAGFRHIDSAYFYKNEKEV 60 Query: 62 GLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMA 121 GLAIRSKIADG+VKREDIFYTSKLWCTF +P++V+P+LE SLK LQLDYVDLY++HFP A Sbjct: 61 GLAIRSKIADGTVKREDIFYTSKLWCTFHRPELVRPSLEDSLKNLQLDYVDLYIIHFPTA 120 Query: 122 LKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPG 181 LKPG +P DE+GK IFDTVD+ ATWE MEKCKDAGLAKSIGVSNFN RQLEMILNKPG Sbjct: 121 LKPGVEIIPTDEHGKAIFDTVDICATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPG 180 Query: 182 LKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVL 241 LKYKPVCNQVECHPYLNQ KLL+FCKSK IVLVA+SALG+ R WVD ++PVLLEDP++ Sbjct: 181 LKYKPVCNQVECHPYLNQGKLLEFCKSKGIVLVAYSALGSHREPEWVDQSAPVLLEDPLI 240 Query: 242 CALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNR 301 ALAKKH+QTPALIALRYQLQRG+VVLAKS+ E+RI+ENIQVFEFQL SEDMKV+D LNR Sbjct: 241 GALAKKHQQTPALIALRYQLQRGIVVLAKSFTEKRIKENIQVFEFQLPSEDMKVIDSLNR 300 Query: 302 NYRYVVMDFLMDHPDYPFSDEY 323 N+RYV DF + HP+YPFSDEY Sbjct: 301 NFRYVTADFAIGHPNYPFSDEY 322 >2HE8-A nrPDB Length = 323 Score = 499 bits (1284), Expect = e-142, Method: Composition-based stats. Identities = 232/323 (71%), Positives = 271/323 (83%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 M+ K V LNDG+F+PVLGFGT P E P+++A E+TK+AI+AGF H DSA +YN E+ Sbjct: 1 MNSKCHCVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDH 60 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 VG AIRSKIADG+V+REDIFYTSK+WCT P++V+ +LE SL+KLQ DYVDLYL+H+PM Sbjct: 61 VGEAIRSKIADGTVRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPM 120 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 ALKPGE P DE+GK+IFD VDL ATWE MEKCKDAGL KSIGVSNFN RQLEMILNKP Sbjct: 121 ALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKP 180 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 GLKYKPVCNQVECHPYLNQ KLLDFCKSKDIVLVA+ LGTQR+ WVD NSPVLL++PV Sbjct: 181 GLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPV 240 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 L ++AKK+ +TPALIALRYQLQRG+VVL S E+RI+EN+QVFEFQL+SEDMKVLDGLN Sbjct: 241 LGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLN 300 Query: 301 RNYRYVVMDFLMDHPDYPFSDEY 323 RN RY+ HP++PF DEY Sbjct: 301 RNMRYIPAAIFKGHPNWPFLDEY 323 >5UXF-A nrPDB Length = 342 Score = 494 bits (1271), Expect = e-140, Method: Composition-based stats. Identities = 213/323 (65%), Positives = 266/323 (82%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 M K V+LNDGH +P LGFGTY P EVP+++++E LA++ G+RH+D+AY Y EE+ Sbjct: 20 MSSKQHCVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEEE 79 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 +G AI+S IA G VKRED+F T+KLWCT F+P++V+PALE SLKKLQLDYVDLY++H+P+ Sbjct: 80 IGQAIQSAIAAGVVKREDLFVTTKLWCTCFRPELVKPALEKSLKKLQLDYVDLYIMHYPV 139 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 +K G+ P +E GK + DTVD TWE +E+CKDAGL KSIGVSNFN RQLE ILNKP Sbjct: 140 PMKSGDNDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKP 199 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 GLKYKPVCNQVECH YLNQ KLLD+C+SKDIVLVA+ ALGTQR+K WVD NSPVLL DPV Sbjct: 200 GLKYKPVCNQVECHLYLNQRKLLDYCESKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPV 259 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 LC +AKK+K++PALIALRY +QRG+V LA+S+ E +REN+QVF FQL+ EDMK LDGLN Sbjct: 260 LCDVAKKNKRSPALIALRYLIQRGIVPLAQSFKENEMRENLQVFGFQLSPEDMKTLDGLN 319 Query: 301 RNYRYVVMDFLMDHPDYPFSDEY 323 +N+RY+ +FL+DHP+YPF +EY Sbjct: 320 KNFRYLPAEFLVDHPEYPFVEEY 342 >3G1R-A nrPDB Length = 346 Score = 490 bits (1262), Expect = e-139, Method: Composition-based stats. Identities = 181/324 (55%), Positives = 240/324 (74%), Gaps = 1/324 (0%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPE-VPRNRAVEVTKLAIEAGFRHIDSAYLYNNEE 59 + R+ L+DG+ +P++G GTY+ P+ P+ K+AI+ G+RHID AY+Y NE Sbjct: 23 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 82 Query: 60 QVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFP 119 +VG AIR KIA+G V+REDIFY KLW T P+MV+P LE +L+ LQLDYVDLY++ P Sbjct: 83 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 142 Query: 120 MALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNK 179 MA KPG+ P+DENGK ++ +L ATWE ME CKDAGL KS+GVSNFN RQLE+ILNK Sbjct: 143 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 202 Query: 180 PGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDP 239 PGLK+KPV NQVECHPY Q KLL FC+ DIV+ A+S LGT R+ +WV+ +SP LL+D Sbjct: 203 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 262 Query: 240 VLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGL 299 +L +L K++ +T A I LR+ +QRGVVV+ KS+N +RI+EN Q+F+F LT E+MK ++ L Sbjct: 263 LLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 322 Query: 300 NRNYRYVVMDFLMDHPDYPFSDEY 323 N+N R+V + DHP+YPF DEY Sbjct: 323 NKNVRFVELLMWRDHPEYPFHDEY 346 >1AFS-A nrPDB Length = 323 Score = 486 bits (1250), Expect = e-138, Method: Composition-based stats. Identities = 224/322 (69%), Positives = 269/322 (83%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 MD RV LNDG+F+PVLGFGT P +V ++ ++ TK+AI+ GFRH DSAYLY EE+ Sbjct: 1 MDSISLRVALNDGNFIPVLGFGTTVPEKVAKDEVIKATKIAIDNGFRHFDSAYLYEVEEE 60 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 VG AIRSKI DG+VKREDIFYTSKLW TF +P++V+ LE +LK QLDYVDLY++HFPM Sbjct: 61 VGQAIRSKIEDGTVKREDIFYTSKLWSTFHRPELVRTCLEKTLKSTQLDYVDLYIIHFPM 120 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 AL+PG+ P+DE+GK++F+TVD+ TWE MEKCKDAGLAKSIGVSNFNCRQLE ILNKP Sbjct: 121 ALQPGDIFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILNKP 180 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 GLKYKPVCNQVECH YLNQSK+LD+CKSKDI+LV++ LG+ R K WVD SPVLL+DPV Sbjct: 181 GLKYKPVCNQVECHLYLNQSKMLDYCKSKDIILVSYCTLGSSRDKTWVDQKSPVLLDDPV 240 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 LCA+AKK+KQTPAL+ALRYQLQRGVV L +S+N +RI+E QVFEFQL SEDMK LDGLN Sbjct: 241 LCAIAKKYKQTPALVALRYQLQRGVVPLIRSFNAKRIKELTQVFEFQLASEDMKALDGLN 300 Query: 301 RNYRYVVMDFLMDHPDYPFSDE 322 RN+RY + DHP++PF+DE Sbjct: 301 RNFRYNNAKYFDDHPNHPFTDE 322 >1ZUA-X nrPDB Length = 317 Score = 479 bits (1232), Expect = e-136, Method: Composition-based stats. Identities = 152/316 (48%), Positives = 207/316 (65%), Gaps = 4/316 (1%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 VEL+ MP++G GT+ + P + E K+AI+AG+RHID AY+Y NE +VG AI+ Sbjct: 6 VELSTKAKMPIVGLGTW---KSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQE 62 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 KI + +VKRED+F SKLW TFF+ +V+ A E +LK L+L Y+D+YL+H+P K G+ Sbjct: 63 KIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDD 122 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187 PKD+ G I WE ME+ D GL K++GVSNF+ Q+E +LNKPGLKYKPV Sbjct: 123 LFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPV 182 Query: 188 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 247 NQVECHPYL Q KL+ +C SK I + A+S LG+ + W P P LLEDP + +A K Sbjct: 183 TNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSP-DRPWAKPEDPSLLEDPKIKEIAAK 241 Query: 248 HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVV 307 HK+T A + +R+ +QR V+V+ KS RI ENIQVF+F+L+ E+M + NRN+R Sbjct: 242 HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN 301 Query: 308 MDFLMDHPDYPFSDEY 323 + DYPF+ EY Sbjct: 302 VLQSSHLEDYPFNAEY 317 >3RX4-A nrPDB Length = 336 Score = 455 bits (1171), Expect = e-128, Method: Composition-based stats. Identities = 152/317 (47%), Positives = 216/317 (68%), Gaps = 4/317 (1%) Query: 7 RVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIR 66 R+ LN+G MP+LG GT+ + P + E K+AI+ G+RHID A++Y NE +VG+AI+ Sbjct: 24 RLLLNNGAKMPILGLGTW---KSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ 80 Query: 67 SKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE 126 K+ + VKRE++F SKLWCT+ + +V+ A + +L L+LDY+DLYL+H+P KPG+ Sbjct: 81 EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK 140 Query: 127 TPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKP 186 P DE+G V+ ++ TW ME+ D GL K+IG+SNFN Q+EMILNKPGLKYKP Sbjct: 141 EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP 200 Query: 187 VCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAK 246 NQ+ECHPYL Q KL+ +C+SK IV+ A+S LG+ + W P P LLEDP + A+A Sbjct: 201 AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSP-DRPWAKPEDPSLLEDPRIKAIAA 259 Query: 247 KHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYV 306 KH +T A + +R+ +QR +VV+ KS +RI EN +VF+F+L+S+DM L NRN+R Sbjct: 260 KHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVC 319 Query: 307 VMDFLMDHPDYPFSDEY 323 + H DYPF +E+ Sbjct: 320 ALLSCTSHKDYPFHEEF 336 >2ALR-A nrPDB Length = 324 Score = 454 bits (1169), Expect = e-128, Method: Composition-based stats. Identities = 135/327 (41%), Positives = 210/327 (64%), Gaps = 16/327 (4%) Query: 7 RVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIR 66 V L+ G MP++G GT+ + + K A+ G+RHID A +Y NE ++G A++ Sbjct: 4 CVLLHTGQKMPLIGLGTW---KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 60 Query: 67 SKIADG-SVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPG 125 + G +V RE++F TSKLW T P+ V+PAL +L LQL+Y+DLYL+H+P A + G Sbjct: 61 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 120 Query: 126 ETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYK 185 + P PK+ +G + +D+ TW+ +E GL +++G+SNFN RQ++ IL+ ++ Sbjct: 121 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR-- 178 Query: 186 PVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALA 245 P QVECHPYL Q++L+ C+++ + + A+S LG+ + W DP+ PVLLE+PV+ ALA Sbjct: 179 PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVVLALA 237 Query: 246 KKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRY 305 +K+ ++PA I LR+Q+QR V+ + KS RI +NI+VF+F + E+MK L+ LN+N+RY Sbjct: 238 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 297 Query: 306 VVMDFLMD---------HPDYPFSDEY 323 +V +D HP YPF+D Y Sbjct: 298 IVPMLTVDGKRVPRDAGHPLYPFNDPY 324 >4GAC-A nrPDB Length = 324 Score = 452 bits (1162), Expect = e-127, Method: Composition-based stats. Identities = 140/327 (42%), Positives = 210/327 (64%), Gaps = 16/327 (4%) Query: 7 RVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIR 66 V L+ G MP++G GT+ + + K A+ AG+RHID A +Y NE ++G A++ Sbjct: 4 SVLLHTGQKMPLIGLGTW---KSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 60 Query: 67 SKIADG-SVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPG 125 + G +V RE++F TSKLW T P+ V+PAL +L LQL+Y+DLYL+H+P A + G Sbjct: 61 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 120 Query: 126 ETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYK 185 + P PK+ +G V +D+ TW+ +E GL K++G+SNFN RQ++ +L+ ++ Sbjct: 121 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVR-- 178 Query: 186 PVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALA 245 P QVECHPYL Q++L+ C ++ + + A+S LG+ + W P+ PVLLE+PV+ ALA Sbjct: 179 PAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSS-DRAWRHPDEPVLLEEPVVLALA 237 Query: 246 KKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRY 305 +KH ++PA I LR+Q+QR V+ + KS N RI +NIQVF+F + E+MK LD LN+N+RY Sbjct: 238 EKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRY 297 Query: 306 VVMDFLMD---------HPDYPFSDEY 323 +V +D HP YPF+D Y Sbjct: 298 IVPMITVDGKRVPRDAGHPLYPFNDPY 324 >1DLA-A nrPDB Length = 314 Score = 451 bits (1160), Expect = e-127, Method: Composition-based stats. Identities = 153/314 (48%), Positives = 210/314 (66%), Gaps = 4/314 (1%) Query: 10 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKI 69 L G MP+LG GT+ + P + E K+AI+ G+RHID A++Y NE +VGL ++ K+ Sbjct: 5 LYTGAKMPILGLGTW---KSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEKL 61 Query: 70 ADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPL 129 VKRED+F SKLWCT + +V+ A +++L+ L+LDY+DLYL+H+P KPG+ P Sbjct: 62 QGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKDPF 121 Query: 130 PKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCN 189 P D +G V+ D D TWE ME+ D GL K+IGVSNFN Q+E ILNKPGLKYKP N Sbjct: 122 PLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVN 181 Query: 190 QVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHK 249 Q+E HPYL Q KL+++CKSK IV+ A+S LG+ + W P P LLEDP + A+A K+ Sbjct: 182 QIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSP-DRPWAKPEDPSLLEDPRIKAIAAKYN 240 Query: 250 QTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVVMD 309 +T A + +R+ +QR ++V+ KS +RI EN QVF+F+L+ EDM L NRN+R + Sbjct: 241 KTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCALM 300 Query: 310 FLMDHPDYPFSDEY 323 H DYPF +EY Sbjct: 301 SCASHKDYPFHEEY 314 >1HQT-A nrPDB Length = 326 Score = 450 bits (1158), Expect = e-127, Method: Composition-based stats. Identities = 134/332 (40%), Positives = 208/332 (62%), Gaps = 16/332 (4%) Query: 2 DPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQV 61 V L+ G MP++G GT+ + + K A+ G+RHID A ++ NE ++ Sbjct: 1 HMAASCVLLHTGQKMPLIGLGTW---KSEPGQVKAAIKYALTVGYRHIDCAAIFGNELEI 57 Query: 62 GLAIRSKIADG-SVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 G A++ + G +V RE++F TSKLW T P+ V+PAL +L LQL+Y+DLYL+H+P Sbjct: 58 GEALQETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPY 117 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 A + G+ P PK+ +G + +D TW+ +E GL +++G+SNF+ RQ++ +L+ Sbjct: 118 AFERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVA 177 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 ++ P QVECHPYL Q++L+ C+++ + + A+S LG+ + W DPN PVLLE+PV Sbjct: 178 SVR--PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPNEPVLLEEPV 234 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 + ALA+K+ ++PA I LR+Q+QR V+ + KS RI +NIQVF+F + E+MK LD LN Sbjct: 235 VQALAEKYNRSPAQILLRWQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALN 294 Query: 301 RNYRYVVMDFLMD---------HPDYPFSDEY 323 +N R++V +D HP YPF+D Y Sbjct: 295 KNLRFIVPMLTVDGKRVPRDAGHPLYPFNDPY 326 >1C9W-A nrPDB Length = 315 Score = 446 bits (1147), Expect = e-126, Method: Composition-based stats. Identities = 151/316 (47%), Positives = 215/316 (68%), Gaps = 4/316 (1%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 VEL+ MP++G GT+ + P + E K+AI+AG+RHID AY Y NE +VG AI+ Sbjct: 4 VELSTKAKMPIVGLGTW---QSPPGQVKEAVKVAIDAGYRHIDCAYAYYNEHEVGEAIQE 60 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 KI + +V+RED+F SKLW T F+ ++++ A + +L L+LDY+DLYL+H+P L+PG+ Sbjct: 61 KIKEKAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKE 120 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187 PKD+ G V+ + WEVME+ D GL K++GVSNFN Q+E ILNKPGLK+KPV Sbjct: 121 LFPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILNKPGLKHKPV 180 Query: 188 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 247 NQVECHPYL Q KL+++C SK I + A+S LG+ ++ W P P LLEDP + +A K Sbjct: 181 TNQVECHPYLTQEKLIEYCHSKGITVTAYSPLGSP-NRPWAKPEDPSLLEDPKIKEIAAK 239 Query: 248 HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVV 307 HK+T A + +R+ +QR VVV+ KS RI EN QVF+FQL+ ++M + G NRN+R + Sbjct: 240 HKKTSAQVLIRFHIQRNVVVIPKSVTPARIHENFQVFDFQLSDQEMATILGFNRNWRACL 299 Query: 308 MDFLMDHPDYPFSDEY 323 + ++ +YP+ EY Sbjct: 300 LPETVNMEEYPYDAEY 315 >1FRB-A nrPDB Length = 315 Score = 442 bits (1136), Expect = e-124, Method: Composition-based stats. Identities = 148/316 (46%), Positives = 212/316 (67%), Gaps = 4/316 (1%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 VEL+ MP++G GT+ + P N+ E K AI+AG+RHID AY Y NE +VG AI+ Sbjct: 4 VELSTKAKMPIVGLGTW---KSPPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQE 60 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 KI + +V+RED+F SKLW T F+ ++++ A + +L L+LDY+DLYL+H+P L+PG+ Sbjct: 61 KIKEKAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKE 120 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187 PKD+ G+++ WE ME+ D GL K++GVSNFN Q+E +LNKPGLK+KPV Sbjct: 121 LFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPV 180 Query: 188 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 247 NQVECHPYL Q KL+ +C SK I + A+S LG+ + P P LLEDP + +A K Sbjct: 181 TNQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSP-DRPSAKPEDPSLLEDPKIKEIAAK 239 Query: 248 HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVV 307 H++T A + +R+ +QR VVV+ KS RI+ENIQVF+FQL+ E+M + NRN+R + Sbjct: 240 HEKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWRACL 299 Query: 308 MDFLMDHPDYPFSDEY 323 + ++ +YP+ EY Sbjct: 300 LPETVNMEEYPYDAEY 315 >3O3R-A nrPDB Length = 316 Score = 435 bits (1118), Expect = e-122, Method: Composition-based stats. Identities = 150/316 (47%), Positives = 209/316 (66%), Gaps = 4/316 (1%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 V+L MP++G GT+ + P + E K AI+AG+RH D AY+Y NE +VG AI+ Sbjct: 5 VKLRTKAKMPLVGLGTW---KSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQE 61 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 KI + +V+RED+F SKLW TFF+ +++ A + +L L+LDY+DLYL+H+P L+ G+ Sbjct: 62 KIKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGKE 121 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187 LPKD GKV+ WE ME+ D GL K++GVSNFN Q+E +LNKPGLK+KPV Sbjct: 122 FLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPV 181 Query: 188 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 247 NQVECHPYL Q KL+ +C SK I ++A+S LG+ + + P PV+LE P + +A K Sbjct: 182 TNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSP-DRPYAKPEDPVVLEIPKIKEIAAK 240 Query: 248 HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVV 307 HK+T A + +R+ +QR V V+ KS I+ENIQVF+FQL+ EDM + LNRN+R Sbjct: 241 HKKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRACG 300 Query: 308 MDFLMDHPDYPFSDEY 323 + D D+PF +EY Sbjct: 301 LFVTSDEEDFPFHEEY 316 >4HBK-A nrPDB Length = 344 Score = 423 bits (1087), Expect = e-119, Method: Composition-based stats. Identities = 132/320 (41%), Positives = 196/320 (61%), Gaps = 9/320 (2%) Query: 4 KYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGL 63 + +++N+G +PV+G GT+ P K A+E G+RH+D AY+Y NE ++G Sbjct: 34 SMEPLKMNNGRSIPVIGLGTW---NSPPGEVGAAVKKALEIGYRHLDCAYVYRNEAEIGE 90 Query: 64 AIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK 123 A+ + + +KREDIF TSKLW TFF+P+ V+ A E +LK L+L+Y+DLYL+H+P+ LK Sbjct: 91 ALENALNSLRLKREDIFITSKLWNTFFRPEHVRKACEETLKNLRLNYLDLYLIHWPVPLK 150 Query: 124 PGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLK 183 G P D NG++ D V TW+ MEK D GL KSIG+SNFN RQ++ IL + Sbjct: 151 HGGDLFPTDSNGQLCLDNVPHEDTWKEMEKLVDEGLVKSIGLSNFNKRQIQNILEH--CR 208 Query: 184 YKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCA 243 KP Q+E H KL+++ +S + + A++ LG+ H P LL P + Sbjct: 209 IKPANLQIEIHANFPNIKLVEYAQSVGLTVTAYAPLGSPAH----SPGKVNLLTKPCVLE 264 Query: 244 LAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNY 303 +A +HK+TPA + LRY LQR ++V+ KS +RI EN QVF+FQL++E+M L+ + N Sbjct: 265 IAHRHKKTPAQVLLRYLLQRKLIVVPKSVTFKRIEENFQVFDFQLSNEEMHELNTESLNE 324 Query: 304 RYVVMDFLMDHPDYPFSDEY 323 R + + H +YPF +EY Sbjct: 325 RQFTLLQMSGHQEYPFKEEY 344 >1K8C-A nrPDB Length = 322 Score = 390 bits (1001), Expect = e-109, Method: Composition-based stats. Identities = 118/326 (36%), Positives = 175/326 (53%), Gaps = 14/326 (4%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 M ++L+ GH MP +GFG + ++ A E AI+AG+R D A Y NE++ Sbjct: 1 MSASIPDIKLSSGHLMPSIGFGCW---KLANATAGEQVYQAIKAGYRLFDGAEDYGNEKE 57 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 VG ++ I +G VKRE+IF TSKLW + P+ V+ AL +L L++DYVDL+L+HFP+ Sbjct: 58 VGDGVKRAIDEGLVKREEIFLTSKLWNNYHDPKNVETALNKTLADLKVDYVDLFLIHFPI 117 Query: 121 ALK--PGETPLPK----DENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLE 174 A K P E P + +++ V + TW+ +EK AG KSIGVSNF L Sbjct: 118 AFKFVPIEEKYPPGFYCGDGNNFVYEDVPILETWKALEKLVAAGKIKSIGVSNFPGALLL 177 Query: 175 MILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRH---KLWVDPN 231 +L G KP QVE HPYL Q KL++F + + + A+S+ G Q N Sbjct: 178 DLLR--GATIKPAVLQVEHHPYLQQPKLIEFAQKAGVTITAYSSFGPQSFVEMNQGRALN 235 Query: 232 SPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSE 291 +P L + A+A K+ +TPA + LR+ QRG+ V+ KS +R+ +N F LT E Sbjct: 236 TPTLFAHDTIKAIAAKYNKTPAEVLLRWAAQRGIAVIPKSNLPERLVQNRSFNTFDLTKE 295 Query: 292 DMKVLDGLNRNYRYVVMDFLMDHPDY 317 D + + L+ R+ + P + Sbjct: 296 DFEEIAKLDIGLRFNDPWDWDNIPIF 321 >3H7U-A nrPDB Length = 335 Score = 388 bits (997), Expect = e-108, Method: Composition-based stats. Identities = 122/320 (38%), Positives = 180/320 (56%), Gaps = 15/320 (4%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 M +LN G P +G GT+ + + A++ G+RHID A +Y NE++ Sbjct: 21 MANAITFFKLNTGAKFPSVGLGTW---QASPGLVGDAVAAAVKIGYRHIDCAQIYGNEKE 77 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 +G ++ D VKRED+F TSKLWCT PQ V AL +LK LQL+YVDLYL+H+P Sbjct: 78 IGAVLKKLFEDRVVKREDLFITSKLWCTDHDPQDVPEALNRTLKDLQLEYVDLYLIHWPA 137 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 +K G + + VD+ +TW+ ME D+G A++IGVSNF+ ++L +L Sbjct: 138 RIKKGSVGIKPEN-----LLPVDIPSTWKAMEALYDSGKARAIGVSNFSTKKLADLLELA 192 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 + P NQVECHP Q+KL +FCKSK + L A+S LG+ W+ + +L++P+ Sbjct: 193 --RVPPAVNQVECHPSWRQTKLQEFCKSKGVHLSAYSPLGSPG-TTWLKSD---VLKNPI 246 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 L +A+K ++PA +ALR+ LQ G VL KS NE RI+EN VF++ + + Sbjct: 247 LNMVAEKLGKSPAQVALRWGLQMGHSVLPKSTNEGRIKENFNVFDWSIPDYMFAKFAEIE 306 Query: 301 RNYRYVVMDFLMDHPDYPFS 320 + R V FL+ P+ Sbjct: 307 Q-ARLVTGSFLVHETLSPYK 325 >5Z6T-A nrPDB Length = 343 Score = 387 bits (993), Expect = e-108, Method: Composition-based stats. Identities = 116/322 (36%), Positives = 170/322 (52%), Gaps = 14/322 (4%) Query: 5 YQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLA 64 ++LN G+ MP +GFG + +V + E AI+ G+R D A Y NE+ VG Sbjct: 26 MPSIKLNSGYDMPAVGFGCW---KVDVDTCSEQIYRAIKTGYRLFDGAEDYANEKLVGAG 82 Query: 65 IRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK- 123 ++ I +G VKRED+F TSKLW + P V+ AL +L LQ+DYVDL+L+HFP+ K Sbjct: 83 VKKAIDEGIVKREDLFLTSKLWNNYHHPDNVEKALNRTLSDLQVDYVDLFLIHFPVTFKF 142 Query: 124 -PGETPLPK----DENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILN 178 P E P + ++ V + TW+ +EK AG +SIGVSNF L +L Sbjct: 143 VPLEEKYPPGFYCGKGDNFDYEDVPILETWKALEKLVKAGKIRSIGVSNFPGALLLDLLR 202 Query: 179 KPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRH---KLWVDPNSPVL 235 G KP QVE HPYL Q +L++F +S+ I + A+S+ G Q N+ L Sbjct: 203 --GATIKPSVLQVEHHPYLQQPRLIEFAQSRGIAVTAYSSFGPQSFVELNQGRALNTSPL 260 Query: 236 LEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKV 295 E+ + A+A KH ++PA + LR+ QRG+ ++ KS R+ EN V F L +D Sbjct: 261 FENETIKAIAAKHGKSPAQVLLRWSSQRGIAIIPKSNTVPRLLENKDVNSFDLDEQDFAD 320 Query: 296 LDGLNRNYRYVVMDFLMDHPDY 317 + L+ N R+ P + Sbjct: 321 IAKLDINLRFNDPWDWDKIPIF 342 >5ZCM-A nrPDB Length = 341 Score = 385 bits (989), Expect = e-107, Method: Composition-based stats. Identities = 107/318 (33%), Positives = 179/318 (56%), Gaps = 14/318 (4%) Query: 3 PKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVG 62 ++LN G+ MP++GFG + +V + AI+ G+R D+A Y N +++G Sbjct: 19 SHMMSIKLNSGYEMPLVGFGCW---KVDNATCADTVYNAIKVGYRLFDAAMDYGNCKEIG 75 Query: 63 LAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMAL 122 I + +G V R+++F TSKLW ++ P+ V+ AL+ L ++LDY+DL+L+HFP+A Sbjct: 76 EGINRALDEGLVARDELFITSKLWNSYHDPKNVELALKKVLSDMKLDYIDLFLIHFPIAF 135 Query: 123 K--PGETPLPK----DENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMI 176 K P E P + ++ V L TW+ MEK G AKSIG+SNF+ + + Sbjct: 136 KFVPFEEKYPPAFYCGDGDNFHYEDVPLLETWKAMEKLTKGGKAKSIGISNFSAALIYDL 195 Query: 177 LNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRH---KLWVDPNSP 233 L G + KP Q+E HPYL Q +L+++ +S+ I + A+S+ G Q K ++P Sbjct: 196 LR--GAEIKPAVLQIEHHPYLQQPRLIEYVQSQGIAITAYSSFGPQSFLELKHSKALDTP 253 Query: 234 VLLEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDM 293 L E + ++A K+K+TPA + LR+ QR + ++ KS N R+ +N++V +F L+ ED Sbjct: 254 TLFEHKTITSIADKYKKTPAQVLLRWASQRDIAIIPKSNNPDRLLQNLEVNDFNLSKEDF 313 Query: 294 KVLDGLNRNYRYVVMDFL 311 + L+++ R+ Sbjct: 314 DEISKLDQDLRFNNPWDW 331 >3WCZ-A nrPDB Length = 308 Score = 384 bits (987), Expect = e-107, Method: Composition-based stats. Identities = 127/323 (39%), Positives = 190/323 (58%), Gaps = 21/323 (6%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVE---VTKLAIEAGFRHIDSAYLYNN 57 M + ++LNDG+ +P++ GT + E AIEAG+RHID+A +Y + Sbjct: 1 MAVQAPCIQLNDGNTIPIVALGTGRGTAKESDSIDEVRQAVYWAIEAGYRHIDTAAVYQD 60 Query: 58 EEQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLH 117 EEQVG I IA+G V RE++F T+KLW V PAL+ SLKKL LDY+DLYL+H Sbjct: 61 EEQVGQGIAEAIANGLVTREELFVTTKLWNDKHARDQVVPALQESLKKLGLDYIDLYLIH 120 Query: 118 FPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMIL 177 FP+A KP ++P D +D TW+ M+ + GLA+SIGVSNFN Q+ ++ Sbjct: 121 FPIATKPDDSP-----------DNIDYLETWQGMQDARQLGLARSIGVSNFNATQITRLV 169 Query: 178 NKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALG--TQRHKLWVDPNSPVL 235 + +PV NQ+E +P Q L+ C+S I ++A+S G R + P Sbjct: 170 SNSY--IRPVINQIEVNPTNTQEPLVAHCQSLGIAVMAYSPFGFVVSRGQTGAPPPRS-- 225 Query: 236 LEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKV 295 +DP L ALA K++++ I LRY + RG++ + KS N+QRI +NI +F+FQLT E++ Sbjct: 226 -DDPTLTALANKYRKSVGQILLRYLIDRGLIPIPKSTNKQRIAQNIDLFDFQLTFEEVAA 284 Query: 296 LDGLNRNYRYVVMDFLMDHPDYP 318 ++ N+N+R + + D+P+YP Sbjct: 285 INQFNKNHRVIDISDWKDYPNYP 307 >5JH1-A nrPDB Length = 309 Score = 382 bits (980), Expect = e-106, Method: Composition-based stats. Identities = 117/314 (37%), Positives = 186/314 (59%), Gaps = 17/314 (5%) Query: 10 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKI 69 LN G +P +G G++ + A++AG+RHID A +Y NE+++GLA++ Sbjct: 6 LNTGAKIPSVGLGSW---QSDPGVVGNAVYAAVKAGYRHIDCARVYGNEKEIGLALKKLF 62 Query: 70 ADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPL 129 +G VKRED+F TSKLW P+ V AL SL LQL+Y+DLYL+H+P +K G Sbjct: 63 EEGVVKREDMFITSKLWNDHHAPEDVPEALNDSLNDLQLEYLDLYLIHWPFRVKKGTNTS 122 Query: 130 PKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCN 189 P++ F T D ATW MEK DAG A++IGVSNF+ ++L +L + P + Sbjct: 123 PEN------FVTPDFPATWGAMEKLYDAGKARAIGVSNFSSKKLGDLLAVA--RVPPAVD 174 Query: 190 QVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHK 249 QVECHP Q+KL FC+S + L A+S LG+ W++ N +L++P++ ++A+K Sbjct: 175 QVECHPGWQQTKLHSFCQSTGVHLTAYSPLGSPG-TTWMNGN---VLKEPIIISIAEKLG 230 Query: 250 QTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVVMD 309 +T A +ALR+ +Q G VL KS NE+RI++N+ V+++ + + + + + R + + Sbjct: 231 KTSAQVALRWNIQMGHSVLPKSTNEERIKQNLDVYDWSIPDDLLAKFSEIKQ-ARLLRGN 289 Query: 310 FLMDHPD-YPFSDE 322 F+++ Y +E Sbjct: 290 FIVNPESVYKTHEE 303 >3H7R-A nrPDB Length = 331 Score = 370 bits (949), Expect = e-103, Method: Composition-based stats. Identities = 117/319 (36%), Positives = 179/319 (56%), Gaps = 20/319 (6%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 M + ELN G +P +G GTYA + AI+ G+RHID A +Y NE++ Sbjct: 21 MAAPIRFFELNTGAKLPCVGLGTYAM-------VATAIEQAIKIGYRHIDCASIYGNEKE 73 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 +G ++ I DG VKRE++F TSKLW P+ V ALE +L+ LQ+DYVDLYL+H+P Sbjct: 74 IGGVLKKLIGDGFVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPA 133 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 +LK E+ +P E + D+++TW+ ME D+G A++IGVSNF+ ++L +LN Sbjct: 134 SLKK-ESLMPTPE----MLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVA 188 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 + P NQVECHP Q L + CKSK + L +S LG+Q +L++P+ Sbjct: 189 --RVTPAVNQVECHPVWQQQGLHELCKSKGVHLSGYSPLGSQSKGE----VRLKVLQNPI 242 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 + +A+K +T A +ALR+ LQ G VL KS + R++EN+ VF++ + + + Sbjct: 243 VTEVAEKLGKTTAQVALRWGLQTGHSVLPKSSSGARLKENLDVFDWSIPEDLFTKFSNIP 302 Query: 301 RNYRYVVMDFLMDHPDYPF 319 + + H + F Sbjct: 303 QEK-FCRATEFA-HETHGF 319 >1QWK-A nrPDB Length = 317 Score = 368 bits (946), Expect = e-102, Method: Composition-based stats. Identities = 124/331 (37%), Positives = 180/331 (54%), Gaps = 25/331 (7%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 M ++L++G MPV+G GT+ + + K A++AG+R ID+A +Y NEE Sbjct: 1 MSSATASIKLSNGVEMPVIGLGTW---QSSPAEVITAVKTAVKAGYRLIDTASVYQNEEA 57 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 +G AI+ + +G VKRE++F T+K W P ++ L SLKKLQL+YVDLYL H P Sbjct: 58 IGTAIKELLEEGVVKREELFITTKAWTHELAPGKLEGGLRESLKKLQLEYVDLYLAHMPA 117 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 A D+ + I V+ W + AGLAK++GVSN+N Q+ L Sbjct: 118 AF--------NDDMSEHIASPVE--DVWRQFDAVYKAGLAKAVGVSNWNNDQISRALA-- 165 Query: 181 GLKYKPVCN-QVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDP--------N 231 L PV N QVE H Y Q +DFCK +I + +++ LG+ + P Sbjct: 166 -LGLTPVHNSQVELHLYFPQHDHVDFCKKHNISVTSYATLGSPGRVNFTLPTGQKLDWAP 224 Query: 232 SPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSE 291 +P L+D + ALA+K +TPA + LRY L RG +L KS E RI+EN +VF+F LT E Sbjct: 225 APSDLQDQNVLALAEKTHKTPAQVLLRYALDRGCAILPKSIQENRIKENFEVFDFSLTEE 284 Query: 292 DMKVLDGLNRNYRYVVMDFLMDHPDYPFSDE 322 D+ L+ + R + DF+ HP+ F+ E Sbjct: 285 DIAKLEESKNSQRLFLQDFMTGHPEDAFAAE 315 >4GIE-A nrPDB Length = 290 Score = 368 bits (944), Expect = e-102, Method: Composition-based stats. Identities = 105/305 (34%), Positives = 160/305 (52%), Gaps = 36/305 (11%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 60 M+ Y V L++ MP LG G + + + AIEAG+RHID+AY+Y+NE Sbjct: 9 MNCNYNCVTLHNSVRMPQLGLGVWRAQDG--AETANAVRWAIEAGYRHIDTAYIYSNERG 66 Query: 61 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 120 VG IR V RE+++ T+K+W + + A E S + L L+Y+DLYL+H+P Sbjct: 67 VGQGIRE----SGVPREEVWVTTKVWNSDQGYEKTLAAFERSRELLGLEYIDLYLIHWPG 122 Query: 121 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 180 K TW+ +EK + ++IGVSNF L + Sbjct: 123 KKK--------------------FVDTWKALEKLYEEKKVRAIGVSNFEPHHLTELFK-- 160 Query: 181 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 240 K +P+ NQVE HP Q L +FCK +I + A S LG+ +L++ V Sbjct: 161 SCKIRPMVNQVELHPLFQQRTLREFCKQHNIAITAWSPLGSG--------EEAGILKNHV 212 Query: 241 LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 L +AKKH ++PA + +R+ +Q G+V + KS N+ RI+EN V++F+LT E+M+ +D LN Sbjct: 213 LGEIAKKHNKSPAQVVIRWDIQHGIVTIPKSTNKGRIQENFNVWDFKLTEEEMRQIDELN 272 Query: 301 RNYRY 305 + R Sbjct: 273 EDKRI 277 >1VBJ-A nrPDB Length = 281 Score = 363 bits (933), Expect = e-101, Method: Composition-based stats. Identities = 118/301 (39%), Positives = 170/301 (56%), Gaps = 39/301 (12%) Query: 5 YQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLA 64 Q ++L++G MPVLGFG + + N A T AI++G+RHID+A +Y NEE G A Sbjct: 9 TQSLKLSNGVMMPVLGFGMWKLQDG--NEAETATMWAIKSGYRHIDTAAIYKNEESAGRA 66 Query: 65 IRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKP 124 I A V RE++F T+KLW + + A E S+KKL L+YVDLYL+H+P K Sbjct: 67 I----ASCGVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLIHWPGKDK- 121 Query: 125 GETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKY 184 TW+ EK ++IGVSNF+ +E +L K Sbjct: 122 -------------------FIDTWKAFEKLYADKKVRAIGVSNFHEHHIEELLKH--CKV 160 Query: 185 KPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCAL 244 P+ NQ+E HP LNQ L ++CKSK+I + A S LG L+ED L A+ Sbjct: 161 APMVNQIELHPLLNQKALCEYCKSKNIAVTAWSPLGQGH-----------LVEDARLKAI 209 Query: 245 AKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYR 304 K+ +T A + LR+++Q GV+ + KS NE RI+EN +F+F+LT+ED++V+DG+N +R Sbjct: 210 GGKYGKTAAQVMLRWEIQAGVITIPKSGNEARIKENGNIFDFELTAEDIQVIDGMNAGHR 269 Query: 305 Y 305 Y Sbjct: 270 Y 270 >4F40-A nrPDB Length = 288 Score = 359 bits (921), Expect = 1e-99, Method: Composition-based stats. Identities = 107/298 (35%), Positives = 156/298 (52%), Gaps = 31/298 (10%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 V L++G MP G G + P K A+ AG+RHID+A +Y NEE VG +R Sbjct: 13 VTLSNGVKMPQFGLGVWQSPAGEVTE--NAVKWALCAGYRHIDTAAIYKNEESVGAGLR- 69 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 V RED+F T+KLW T + A E S +KL +DY+DLYL+H+P G+ Sbjct: 70 ---ASGVPREDVFITTKLWNTEQGYESTLAAFEESRQKLGVDYIDLYLIHWP----RGKD 122 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187 L K + +W E+ ++IGVSNF+ LE +L P+ Sbjct: 123 ILSK--------EGKKYLDSWRAFEQLYKEKKVRAIGVSNFHIHHLEDVL--AMCTVTPM 172 Query: 188 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 247 NQVE HP NQ+ L FC +K I + A S LG + LL +P+L A+ K Sbjct: 173 VNQVELHPLNNQADLRAFCDAKQIKVEAWSPLGQGK-----------LLSNPILSAIGAK 221 Query: 248 HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRY 305 + +T A + LR+ +Q+ ++ + KS + +RI EN +F+F+L +ED+ +D LN N RY Sbjct: 222 YNKTAAQVILRWNIQKNLITIPKSVHRERIEENADIFDFELGAEDVMSIDALNTNSRY 279 >2BGQ-A nrPDB Length = 344 Score = 356 bits (913), Expect = 8e-99, Method: Composition-based stats. Identities = 112/302 (37%), Positives = 166/302 (54%), Gaps = 19/302 (6%) Query: 10 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKI 69 L GH MP +G GT+ + A V EAG+RH+D+A Y E++VG +++ + Sbjct: 42 LKSGHAMPAVGLGTWR---AGSDTAHSVRTAITEAGYRHVDTAAEYGVEKEVGKGLKAAM 98 Query: 70 ADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPL 129 + + R+D+F TSK+WCT P+ V+PALE++LK LQLDY+DLY +H+P LK G Sbjct: 99 -EAGIDRKDLFVTSKIWCTNLAPERVRPALENTLKDLQLDYIDLYHIHWPFRLKDGAHMP 157 Query: 130 PKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCN 189 P E G+V+ D+ W+ ME GL K IGV N+ +L +L K P Sbjct: 158 P--EAGEVLE--FDMEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLRSA--KIPPAVC 211 Query: 190 QVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHK 249 Q+E HP K+ + CK I + A+S LG+ L DPV+ +A K Sbjct: 212 QMEMHPGWKNDKIFEACKKHGIHITAYSPLGSSEKN---------LAHDPVVEKVANKLN 262 Query: 250 QTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYVVMD 309 +TP + +++ LQRG V+ KS ++RI+ENIQVF +++ ED KVL + R + + Sbjct: 263 KTPGQVLIKWALQRGTSVIPKSSKDERIKENIQVFGWEIPEEDFKVLCSIKDEKRVLTGE 322 Query: 310 FL 311 L Sbjct: 323 EL 324 >3KRB-A nrPDB Length = 334 Score = 351 bits (901), Expect = 2e-97, Method: Composition-based stats. Identities = 104/310 (33%), Positives = 161/310 (51%), Gaps = 23/310 (7%) Query: 14 HFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKIAD-- 71 + P LGFGT+ + P + A+ G+RHID AY+Y NEE +G A D Sbjct: 23 QYPPRLGFGTW---QAPPEAVQTAVETALMTGYRHIDCAYVYQNEEAIGRAFGKIFKDAS 79 Query: 72 GSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE--TPL 129 +KRED++ TSKLW +P++V+ + ++ LQ+DY+DL+L+H+P+A + Sbjct: 80 SGIKREDVWITSKLWNYNHRPELVREQCKKTMSDLQVDYLDLFLVHWPLAFVRNDVGDLF 139 Query: 130 PKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCN 189 PKD G+ + + V L+ TW ME+ + GL K IGVSN+ L +LN K KP+ N Sbjct: 140 PKDAEGRAMLEKVPLADTWRAMEQLVEEGLVKHIGVSNYTVPLLADLLNYA--KIKPLVN 197 Query: 190 QVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSP------VLLEDPVLCA 243 Q+E HP+ + FC I + A+S +G + DP P V+LE L A Sbjct: 198 QIEIHPWHPNDATVKFCLDNGIGVTAYSPMGGS----YADPRDPSGTQKNVILECKTLKA 253 Query: 244 LAKKHKQTPALIALRYQLQRGV----VVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGL 299 +A +P +AL + +++ V+ KS RI N + E QL+ +DM ++ + Sbjct: 254 IADAKGTSPHCVALAWHVKKWNTSMYSVIPKSQTPARIEANFKCTEVQLSDDDMDAINNI 313 Query: 300 NRNYRYVVMD 309 + N R D Sbjct: 314 HLNKRIRFCD 323 >1VP5-A nrPDB Length = 298 Score = 343 bits (879), Expect = 8e-95, Method: Composition-based stats. Identities = 99/302 (32%), Positives = 163/302 (53%), Gaps = 35/302 (11%) Query: 6 QRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAI 65 +V LN+G MP+LG+G + ++P + E AI+ G+R ID+A Y NEE VG AI Sbjct: 16 PKVTLNNGVEMPILGYGVF---QIPPEKTEECVYEAIKVGYRLIDTAASYMNEEGVGRAI 72 Query: 66 RSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPG 125 + I +G V+RE++F T+KLW + + + A E SLKKLQL+Y+DLYL+H P Sbjct: 73 KRAIDEGIVRREELFVTTKLWVSDVGYESTKKAFEKSLKKLQLEYIDLYLIHQPFG---- 128 Query: 126 ETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYK 185 D+ W+ ME+ GL ++IGVSNF +L ++ + Sbjct: 129 -----------------DVHCAWKAMEEMYKDGLVRAIGVSNFYPDRLMDLMVHH--EIV 169 Query: 186 PVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALA 245 P NQ+E HP+ + + ++F ++ +I A R + ++ VL ++A Sbjct: 170 PAVNQIEIHPFYQRQEEIEFMRNYNIQPEAWGPFAEGRKN---------IFQNGVLRSIA 220 Query: 246 KKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRY 305 +K+ +T A + LR+ Q+G+V + K+ +R++ENI +F+F+LT EDM+ + L+ Sbjct: 221 EKYGKTVAQVILRWLTQKGIVAIPKTVRRERMKENISIFDFELTQEDMEKIATLDEGQSA 280 Query: 306 VV 307 Sbjct: 281 FF 282 >1MZR-A nrPDB Length = 296 Score = 333 bits (854), Expect = 7e-92, Method: Composition-based stats. Identities = 97/298 (32%), Positives = 151/298 (50%), Gaps = 38/298 (12%) Query: 8 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 67 ++L DG+ MP LG G + + + + A+E G+R ID+A Y NEE VG A+++ Sbjct: 28 IKLQDGNVMPQLGLGVW---QASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKN 84 Query: 68 KIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGET 127 SV RE++F T+KLW + + AL SLKKLQLDY+DLYL+H+P+ Sbjct: 85 A----SVNREELFITTKLWNDDHK--RPREALLDSLKKLQLDYIDLYLMHWPVPAID--- 135 Query: 128 PLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPV 187 W+ M + + GL KSIGV NF L+ ++++ G PV Sbjct: 136 ---------------HYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETG--VTPV 178 Query: 188 CNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKK 247 NQ+E HP + Q +L + + I + S L + + V+ LA K Sbjct: 179 INQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGK---------GVFDQKVIRDLADK 229 Query: 248 HKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRY 305 + +TPA I +R+ L G+VV+ KS RI EN V++F+L +++ + L++ R Sbjct: 230 YGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 287 >4IJC-A nrPDB Length = 344 Score = 330 bits (846), Expect = 6e-91, Method: Composition-based stats. Identities = 111/333 (33%), Positives = 177/333 (53%), Gaps = 32/333 (9%) Query: 1 MDPKYQRV--ELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNE 58 + PK + LN+G +P LG GT P E + K AI+AG+RHID+A+ Y E Sbjct: 16 LHPKTTEIYFSLNNGVRIPALGLGTANPHE-KLAETKQAVKAAIKAGYRHIDTAWAYETE 74 Query: 59 EQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHF 118 VG AI+ + DGS+KRED+F T+K+W + V +L SLK L L+YVDL L H+ Sbjct: 75 PFVGEAIKELLEDGSIKREDLFITTKVWPVLW--DEVDRSLNESLKALGLEYVDLLLQHW 132 Query: 119 PMALKPGETP--------LPKDENGKVIF-DTVDLSATWEVMEKCK---DAGLAKSIGVS 166 P+ + + P P D++GK ++ D T++ +EK + ++IGVS Sbjct: 133 PLCFEKIKDPKGISGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDPNDHRVRAIGVS 192 Query: 167 NFNCRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKL 226 NF+ LE ++ + + KP NQVE HP+L Q +L FC DI+L A+S LG+ Sbjct: 193 NFSIEYLERLIKE--CRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPN 250 Query: 227 WVDPNSPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEF 286 L+ P++ LA+K+ T + + Y +++G +V+ +S N RI +I+ Sbjct: 251 ---------LKIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEF--A 299 Query: 287 QLTSEDMKVLDGLNRNY--RYVVMDFLMDHPDY 317 LT ++++ L+ Y R++ F P++ Sbjct: 300 SLTKDELQELNDFGEKYPVRFIDEPFAAILPEF 332 >3D3F-A nrPDB Length = 275 Score = 324 bits (831), Expect = 3e-89, Method: Composition-based stats. Identities = 114/299 (38%), Positives = 159/299 (53%), Gaps = 39/299 (13%) Query: 7 RVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIR 66 V+L++G MP G G + N A E K AI+ G+R ID+A +Y NEE VG+ I+ Sbjct: 7 TVKLHNGVEMPWFGLGVFKVENG--NEATESVKAAIKNGYRSIDTAAIYKNEEGVGIGIK 64 Query: 67 SKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE 126 V RE++F TSK+W + A E SL++LQLDY+DLYL+H+P K Sbjct: 65 E----SGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWPGKDK--- 117 Query: 127 TPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKP 186 TW +EK G ++IGVSNF LE +L + KP Sbjct: 118 -----------------YKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDA--EIKP 158 Query: 187 VCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAK 246 + NQVE HP L Q +L D+CK + I L A S L + LL++ VL +A+ Sbjct: 159 MVNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQ-----------LLDNEVLTQIAE 207 Query: 247 KHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRY 305 KH ++ A + LR+ LQ GVV + KS E RI EN +F+F+L+ EDM +D LN++ R Sbjct: 208 KHNKSVAQVILRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERV 266 >4MHB-A nrPDB Length = 297 Score = 321 bits (824), Expect = 2e-88, Method: Composition-based stats. Identities = 98/299 (32%), Positives = 151/299 (50%), Gaps = 38/299 (12%) Query: 2 DPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQV 61 D Q V+LN+G MP+LGFG + AIE G+R ID+A Y NE QV Sbjct: 12 DNVMQTVKLNNGIAMPLLGFGVFQMTNT--AECERAVIDAIETGYRLIDTAASYQNETQV 69 Query: 62 GLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMA 121 G A++ + R+++F T+KLW + + E SL +LQLDYVDLYL+H P Sbjct: 70 GNALKL----SGIARDELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLIHQPYG 125 Query: 122 LKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPG 181 D+ W ME+ AG ++IGVSNF+ +L ++ Sbjct: 126 ---------------------DVHGAWRAMEELHQAGKIRAIGVSNFHPDRLADLM--AF 162 Query: 182 LKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVL 241 K P NQ+E +P+ Q + + +S+ I A + R+ L ++PVL Sbjct: 163 NKIIPAVNQIEVNPFNQQLHAVPWMQSRGIQPEAWAPFAEGRN---------GLFQNPVL 213 Query: 242 CALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 A+ +K+ ++ + LR+ QRG+V LAKS + R+ ENI + +F+L++EDM + L+ Sbjct: 214 TAIGEKYGKSVGQVVLRWIFQRGIVSLAKSVRKGRMEENINILDFELSAEDMLQIAALD 272 >4OTK-A nrPDB Length = 318 Score = 307 bits (787), Expect = 4e-84, Method: Composition-based stats. Identities = 106/309 (34%), Positives = 145/309 (46%), Gaps = 38/309 (12%) Query: 3 PKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVG 62 + LND H MPVLG G + RAV A+E G R ID+AY Y NE VG Sbjct: 44 AAAPSITLNDEHTMPVLGLGVAELSDDETERAVSA---ALEIGCRLIDTAYAYGNEAAVG 100 Query: 63 LAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMAL 122 AI A V RE++F T+KL Q A +SL +L LDYVDLYL+H+P Sbjct: 101 RAI----AASGVAREELFVTTKLATPDQGFTRSQEACRASLDRLGLDYVDLYLIHWPAPP 156 Query: 123 KPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGL 182 GK W M + + G A+SIGVSNF +E +++ Sbjct: 157 V-----------GK-------YVDAWGGMIQSRGEGHARSIGVSNFTAENIENLIDLTF- 197 Query: 183 KYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLC 242 P NQ+E HP LNQ +L +V ++ L R LL++P + Sbjct: 198 -VTPAVNQIELHPLLNQDELRKANAQHTVVTQSYCPLALGR-----------LLDNPTVT 245 Query: 243 ALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRN 302 ++A ++ +TPA + LR+ LQ G V+ +S +RI N VF+F+L +E M L GLN Sbjct: 246 SIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIASNFDVFDFELAAEHMDALGGLNDG 305 Query: 303 YRYVVMDFL 311 R Sbjct: 306 TRVREDPLT 314 >1A80-A nrPDB Length = 277 Score = 299 bits (767), Expect = 8e-82, Method: Composition-based stats. Identities = 101/295 (34%), Positives = 147/295 (49%), Gaps = 36/295 (12%) Query: 6 QRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAI 65 + LNDG+ +P LG+G + P RAVE A+E G+RHID+A +Y NEE V Sbjct: 3 PSIVLNDGNSIPQLGYGVFKVPPADTQRAVE---EALEVGYRHIDTAAIYGNEEGV---- 55 Query: 66 RSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPG 125 + IA + R+D+F T+KLW A+ SL KL LD VDLYL+H+P Sbjct: 56 GAAIAASGIARDDLFITTKLWNDRHDGDEPAAAIAESLAKLALDQVDLYLVHWPTP---- 111 Query: 126 ETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYK 185 + WE M + + AGL +SIGVSN LE I+ G Sbjct: 112 --------------AADNYVHAWEKMIELRAAGLTRSIGVSNHLVPHLERIVAATG--VV 155 Query: 186 PVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALA 245 P NQ+E HP Q ++ D+ + D+ + + LG ++ L+ + A A Sbjct: 156 PAVNQIELHPAYQQREITDWAAAHDVKIESWGPLGQGKYDLFGAEP---------VTAAA 206 Query: 246 KKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 300 H +TPA LR+ LQ+G VV KS +R+ EN+ VF+F LT ++ +D ++ Sbjct: 207 AAHGKTPAQAVLRWHLQKGFVVFPKSVRRERLEENLDVFDFDLTDTEIAAIDAMD 261 >3UP8-A nrPDB Length = 298 Score = 286 bits (732), Expect = 9e-78, Method: Composition-based stats. Identities = 94/309 (30%), Positives = 158/309 (51%), Gaps = 43/309 (13%) Query: 11 NDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKIA 70 ++G +P LGFGT+ + + A++ GFRH+D+A +Y NE +VG AI+ Sbjct: 29 SNGANIPALGFGTFRMSGA---EVLRILPQALKLGFRHVDTAQIYGNEAEVGEAIQK--- 82 Query: 71 DGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLP 130 + R D+F T+K+W ++ +++ SL+KL+ D+VDL LLH+P Sbjct: 83 -SGIPRADVFLTTKVWVDNYRHDAFIASVDESLRKLRTDHVDLLLLHWPG---------- 131 Query: 131 KDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQ 190 V ++ + + ++AG + IG+SNFN Q+E NQ Sbjct: 132 ---------SDVPMAERIGALNEVRNAGKVRHIGISNFNTTQMEEAARLSDAPI--ATNQ 180 Query: 191 VECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKQ 250 VE HPYL+Q+K+L + + L ++ A+ + + DP+L + +H + Sbjct: 181 VEYHPYLDQTKVLQTARRLGMSLTSYYAMANGK-----------VPADPLLTEIGGRHGK 229 Query: 251 TPALIALRYQL-QRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNR-NYRYVVM 308 T A +ALR+ + Q+ V+VL+K+ E R++EN +F+F LT E+M + L R N R V Sbjct: 230 TAAQVALRWLVQQQDVIVLSKTATEARLKENFAIFDFALTREEMAAVRELARPNGRIVNP 289 Query: 309 DFLMDHPDY 317 L P++ Sbjct: 290 QGLA--PEW 296 >3WG6-A nrPDB Length = 307 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 90/319 (28%), Positives = 157/319 (49%), Gaps = 40/319 (12%) Query: 1 MDPKYQRVELNDGHFMPVLGFGTY-----APPEVPRNRAVEVTKLAIEAGFRHIDSAYLY 55 M + +L++G+ +P + FGT + + +LA+ +GFRHID A +Y Sbjct: 4 MSLAGKEFKLSNGNKIPAVAFGTGTKYFKRGHNDLDKQLIGTLELALRSGFRHIDGAEIY 63 Query: 56 NNEEQVGLAIRSKIADGSVKREDIFYTSKLWCTFF-------QPQMVQPALESSLKKLQL 108 +++G+A+++ + R+D+F T K + Q AL++ L+ L L Sbjct: 64 GTNKEIGIALKNV----GLNRKDVFITDKYNSGNHTYDGKHSKHQNPYNALKADLEDLGL 119 Query: 109 DYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNF 168 +YVDLYL+HFP + DL W +E+ K+ GLA++IGVSNF Sbjct: 120 EYVDLYLIHFPYISEKS--------------HGFDLVEAWRYLERAKNEGLARNIGVSNF 165 Query: 169 NCRQLEMILNKPGLKYKPVCNQVECHPYLNQ--SKLLDFCKSKDIVLVAHSALGTQRHKL 226 L+ IL+ PV NQ+E YL ++++ + + I++ A+ LG Sbjct: 166 TIENLKSILD-ANTDSIPVVNQIEFSAYLQDQTPGIVEYSQQQGILIEAYGPLGP----- 219 Query: 227 WVDPNSPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEF 286 + P L D VL L++K+K+ I LR+ LQRG++ + + E+RI + +++F+F Sbjct: 220 -ITQGRPGPL-DKVLSKLSEKYKRNEGQILLRWVLQRGILPITTTSKEERINDVLEIFDF 277 Query: 287 QLTSEDMKVLDGLNRNYRY 305 +L ED + + + Sbjct: 278 ELDKEDEDQITKVGKEKTL 296 >4H8N-A nrPDB Length = 310 Score = 268 bits (685), Expect = 2e-72, Method: Composition-based stats. Identities = 90/310 (29%), Positives = 148/310 (47%), Gaps = 37/310 (11%) Query: 18 VLGFGT-YAPPEVPRNRAVEVTK---LAIEAGFRHIDSAYLYNNEEQVGLAIRSKIADGS 73 LG GT + + + + E+ L ++ GFRHID+A YN +++VG A++ Sbjct: 25 ALGTGTKWKQAQTINDVSTELVDNILLGLKLGFRHIDTAEAYNTQKEVGEALKRT----D 80 Query: 74 VKREDIFYTSKL---WCTFFQP-QMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPL 129 V REDI+ T+K W + + +++ +L +L +DYVDL+L+H P Sbjct: 81 VPREDIWVTTKYSPGWGSIKAYSKSPSDSIDKALAQLGVDYVDLFLIHSPFFTTEQTHGY 140 Query: 130 PKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILN-KPGLKYKPVC 188 L WE + + K AG + IG+SN LE + P +Y PV Sbjct: 141 -------------TLEQAWEALVEAKKAGKVREIGISNAAIPHLEKLFAASPSPEYYPVV 187 Query: 189 NQVECHPYLNQSK--LLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAK 246 NQ+E HP+L ++ FC+ I++ A S L L LA+ Sbjct: 188 NQIEFHPFLQNQSKNIVRFCQEHGILVEAFSPLAPLARVETNALAE-------TLKRLAE 240 Query: 247 KHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRN--YR 304 K+K+T A + LRY LQRG++ + S E R++E++ +F+F+LT E++ ++ + YR Sbjct: 241 KYKKTEAQVLLRYTLQRGILPVTTSSKESRLKESLNLFDFELTDEEVNEINKIGDANPYR 300 Query: 305 YVVMDFLMDH 314 + D Sbjct: 301 AFFHEQFKDL 310 >1LQA-A nrPDB Length = 346 Score = 177 bits (449), Expect = 5e-45, Method: Composition-based stats. Identities = 75/357 (21%), Positives = 138/357 (38%), Gaps = 70/357 (19%) Query: 4 KYQRVELNDGHFMPVLGFGTYAPPEVPRNR-AVEVTKLAIEAGFRHIDSAYLYN------ 56 +Y R+ + + LG GT E A A+ G ID A +Y Sbjct: 2 QYHRIP-HSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPE 60 Query: 57 ----NEEQVGLAIRSKIADGSVKREDIFYTSKLWCTF------------FQPQMVQPALE 100 E VG + + RE + SK+ + ++ AL Sbjct: 61 TQGLTETYVGNWLAKHGS-----REKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALH 115 Query: 101 SSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFD------TVDLSATWEVMEKC 154 SLK+LQ DY+DLY +H+P P + GK+ + V L T + + + Sbjct: 116 DSLKRLQTDYLDLYQVHWPQR--------PTNCFGKLGYSWTDSAPAVSLLDTLDALAEY 167 Query: 155 KDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVECHPY--LNQS---KLLDFCKSK 209 + AG + IGVSN + L+ P ++ +PY LN+S L + + + Sbjct: 168 QRAGKIRYIGVSNETAFGVMRYLHLADKHDLPRIVTIQ-NPYSLLNRSFEVGLAEVSQYE 226 Query: 210 DIVLVAHSALGTQR-HKLWVDPNSPVLLEDPVLCA------------------LAKKHKQ 250 + L+A+S LG +++ P + + +A++H Sbjct: 227 GVELLAYSCLGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGL 286 Query: 251 TPALIALRYQLQRGVV--VLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRY 305 PA +AL + ++ V L + +++ NI+ +L+ + + ++ +++ Y Y Sbjct: 287 DPAQMALAFVRRQPFVASTLLGATTMDQLKTNIESLHLELSEDVLAEIEAVHQVYTY 343 >1PZ1-A nrPDB Length = 333 Score = 163 bits (413), Expect = 8e-41, Method: Composition-based stats. Identities = 78/331 (23%), Positives = 136/331 (41%), Gaps = 67/331 (20%) Query: 12 DGHFMPVLGFGTYAPPEV-----PRNRAVEVTKLAIEAGFRHIDSAYLYN---NEEQVGL 63 G +G GT+A ++E + A++ G ID+A Y +EE VG Sbjct: 9 TGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAALDQGITLIDTAPAYGFGQSEEIVGK 68 Query: 64 AIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPA--------LESSLKKLQLDYVDLYL 115 AI+ + KR+ + +K + Q+ + A +E+SLK+LQ DY+DLY Sbjct: 69 AIKEYM-----KRDQVILATKTALDWKNNQLFRHANRARIVEEVENSLKRLQTDYIDLYQ 123 Query: 116 LHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEM 175 +H+P L P E T EVM++ DAG ++IGVSNF+ Q++ Sbjct: 124 VHWPDPLVPIEE-------------------TAEVMKELYDAGKIRAIGVSNFSIEQMDT 164 Query: 176 ILNKPGLK-YKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSAL--GTQRHKLWVD--- 229 L +P N E + +L + K I + + +L G K+ + Sbjct: 165 FRAVAPLHTIQPPYNLFERE---MEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEEYTF 221 Query: 230 -----PNSPVLLEDPVLCA----------LAK-KHKQTPALIALRYQLQRGVVVLA--KS 271 N + P LAK ++ ++ +A+R+ L + +A + Sbjct: 222 EGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADIALWGA 281 Query: 272 YNEQRIRENIQVFEFQLTSEDMKVLDGLNRN 302 ++ ++ + L SED K ++ + N Sbjct: 282 RKPGQLEALSEITGWTLNSEDQKDINTILEN 312 >1PYF-A nrPDB Length = 312 Score = 161 bits (408), Expect = 3e-40, Method: Composition-based stats. Identities = 77/322 (23%), Positives = 129/322 (40%), Gaps = 70/322 (21%) Query: 19 LGFGTYAP------PEVPRNRAVEVTKLAIEAGFRHIDSAYLYN---NEEQVGLAIRSKI 69 +G GT A P + E+ + AI G +D+AY+Y +EE +G +R Sbjct: 16 IGLGTNAVGGHNLYPNLNEETGKELVREAIRNGVTMLDTAYIYGIGRSEELIGEVLRE-- 73 Query: 70 ADGSVKREDIFYTSKL--------WCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMA 121 RED+ +K + P ++ +++ SLK+L DY+DL+ +HFP Sbjct: 74 ----FNREDVVIATKAAHRKQGNDFVFDNSPDFLKKSVDESLKRLNTDYIDLFYIHFP-- 127 Query: 122 LKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPG 181 + PKD + + K AG +SIGVSNF+ QL+ NK G Sbjct: 128 ----DEHTPKD-------------EAVNALNEMKKAGKIRSIGVSNFSLEQLKEA-NKDG 169 Query: 182 LKYKPVCNQVECHPYLNQSK--LLDFCKSKDIVLVAHSAL--GTQRHKLWVDPNSP-VLL 236 L Q E + +++ + K +I + + L G K D P L Sbjct: 170 LVD---VLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTEDTTFPEGDL 226 Query: 237 EDP-----------------VLCALAKKHKQTPALIALRYQLQRGV--VVLAKSYNEQRI 277 + L +A+KH I L + L R +++ + ++ Sbjct: 227 RNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDILIPGAKRADQL 286 Query: 278 RENIQVFEFQLTSEDMKVLDGL 299 +NI+ + L+ ED+ +D L Sbjct: 287 IDNIKTADVTLSQEDISFIDKL 308 >2CLP-A nrPDB Length = 347 Score = 128 bits (321), Expect = 4e-30, Method: Composition-based stats. Identities = 62/317 (19%), Positives = 112/317 (35%), Gaps = 64/317 (20%) Query: 33 RAVEVTKLAIEAGFRHIDSAYLY--NNEEQVGLAIRSKIADGSVKREDIFYTSKLWCTFF 90 + VT+ +E G ID+A++Y E + + ++ + + L+ Sbjct: 43 TSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSL 102 Query: 91 QPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPK----DENGKVIFDTVDLSA 146 +P ++ LE+SLK+LQ VDL+ LH P P E L + GK + + A Sbjct: 103 KPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYA 162 Query: 147 TWEVMEKCKDAGLAKS---------IGVSNFNCRQLEMILNKPGLKYKPVCNQVECHPYL 197 WEV E C L KS G+ N RQ+E E P L Sbjct: 163 AWEVAEICT---LCKSNGWILPTVYQGMYNAITRQVET----------------ELFPCL 203 Query: 198 NQSKLLDFCK---SKDIVLVAH--------SALGTQRHKLWVDPNSPVLLEDPVLCALA- 245 L + + ++ + +G W + ++ +A Sbjct: 204 RHFGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIAL 263 Query: 246 ------KKHKQTPALI---ALRY-----QLQ--RGVVVLAKSYNEQRIRENIQVFEFQLT 289 + + + LR+ QLQ G V+ + +++ +N+ + Sbjct: 264 VEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAA--AEEG 321 Query: 290 SEDMKVLDGLNRNYRYV 306 + V+D N+ + V Sbjct: 322 PLEPAVVDAFNQAWHLV 338 >1GVE-A nrPDB Length = 327 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 43/174 (24%), Positives = 73/174 (41%), Gaps = 13/174 (7%) Query: 17 PVLGFGTYAPPE-VPRNRAVEVTKLAIEAGFRHIDSAYLYNN--EEQVGLAIRSKIADGS 73 P G + + + ++ G ID+A++Y N E + + + Sbjct: 6 PATVLGAMEMGRRMDVTSSSASVRAFLQRGHTEIDTAFVYANGQSETILGDLGLGLGRSG 65 Query: 74 VKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPK-- 131 K + + ++ +P V+ LE+SLK+LQ VDL+ LHFP P E L Sbjct: 66 CKVKIATKAAPMFGKTLKPADVRFQLETSLKRLQCPRVDLFYLHFPDHGTPIEETLQACH 125 Query: 132 --DENGKVIFDTVDLSATWEVMEKC----KDAGLAKSI--GVSNFNCRQLEMIL 177 + GK + + +WEV E C K+ + ++ G+ N RQ+E L Sbjct: 126 QLHQEGKFVELGLSNYVSWEVAEICTLCKKNGWIMPTVYQGMYNAITRQVETEL 179 >2BP1-A nrPDB Length = 360 Score = 124 bits (311), Expect = 5e-29, Method: Composition-based stats. Identities = 68/333 (20%), Positives = 118/333 (35%), Gaps = 71/333 (21%) Query: 21 FGTYAPPE-VPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKIADGSVK-RED 78 GT + + + +E G +D+A++Y++ + + + G R Sbjct: 43 LGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVK 102 Query: 79 IFYTSKLW-CTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPK----DE 133 I + W +P V+ LE+SLK+LQ VDL+ LH P P E L + Sbjct: 103 IATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQ 162 Query: 134 NGKVIFDTVDLSATWEVMEKCKDAGLAKS---------IGVSNFNCRQLEMILNKPGLKY 184 GK + + A+WEV E C L KS G+ N RQ+E Sbjct: 163 EGKFVELGLSNYASWEVAEICT---LCKSNGWILPTVYQGMYNATTRQVET--------- 210 Query: 185 KPVCNQVECHPYLNQSKLLDFC---KSKDIVLVAH--------SALGTQRHKLWVDPNSP 233 E P L L + + ++ + +G W + Sbjct: 211 -------ELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRN 263 Query: 234 VLLEDPVLCALA-------KKHKQTPALI---ALRY-----QLQ--RGVVVLAKSYNEQR 276 ++ A+A + + + ALR+ QLQ G V+ + ++ Sbjct: 264 RFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQ 323 Query: 277 IRENIQVFEFQLTSE---DMKVLDGLNRNYRYV 306 + +N+ T E + V+D N+ + V Sbjct: 324 LEQNLAA-----TEEGPLEPAVVDAFNQAWHLV 351 >2C91-A nrPDB Length = 338 Score = 123 bits (310), Expect = 7e-29, Method: Composition-based stats. Identities = 71/330 (21%), Positives = 123/330 (37%), Gaps = 63/330 (19%) Query: 17 PVLGFGTYAPPE-VPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKIA----D 71 P GT + + + + +E G +D+A++Y + + + + D Sbjct: 17 PATVLGTMEMGRRMDASASAASVRAFLERGHSELDTAFMYCDGQSENILGGLGLGLGSGD 76 Query: 72 GSVKREDIFYTSKLW-CTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLP 130 +VK I + W +P ++ LE+SLK+LQ VDL+ LH P P E L Sbjct: 77 CTVK---IATKANPWEGKSLKPDSIRSQLETSLKRLQCPRVDLFYLHAPDHSTPVEETLC 133 Query: 131 K----DENGKVIFDTVDLSATWEVMEKCKDAGLAKS---------IGVSNFNCRQLEMI- 176 + GK + + A+WEV E C L KS G+ N RQ+E Sbjct: 134 ACHQLHQEGKFVELGLSNYASWEVAEICT---LCKSNGWILPTVYQGMYNATTRQVEAEL 190 Query: 177 ---LNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSP 233 L GL++ Y + L K K +G W + Sbjct: 191 LPCLRHFGLRFY---------AYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNNWAETYRN 241 Query: 234 VLLEDPVLCALA--KK-----HKQTPALI---ALRY-----QLQ--RGVVVLAKSYNEQR 276 ++ A+A +K + + ALR+ QLQ RG V+ + ++ Sbjct: 242 RFWKEHHFEAIALVEKALQTTYGTNAPRMTSAALRWMYHHSQLQGTRGDAVILGMSSLEQ 301 Query: 277 IRENIQVFEFQLTSE---DMKVLDGLNRNY 303 + +N+ T E + V++ ++ + Sbjct: 302 LEQNLAA-----TEEGPLEPAVVEAFDQAW 326 >4R9O-A nrPDB Length = 301 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 109/307 (35%), Gaps = 54/307 (17%) Query: 21 FGTYAPPE--VPRNRAVEVTKLAIEAGFRHIDSAYLYNN---EEQVGLAIRSKIADGSVK 75 G + + + + V + ++ G +D A +Y E G A+ Sbjct: 22 MGYWRLMDWNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALTLAPHL---- 77 Query: 76 REDIFYTSK------------LWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK 123 RE + +K L + + + E SLK L DY+D+ L+H P L Sbjct: 78 REKLQIVTKCGIATTARAENKLGHYITDRRHIILSAEQSLKNLATDYLDMLLIHRPDPLM 137 Query: 124 PGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLK 183 + E + +G + GVSNF Q ++ ++ L Sbjct: 138 DADDVA-------------------EAFQHLHQSGKVRHFGVSNFTPAQFTLLQSR--LP 176 Query: 184 YKPVCNQVECHPYLNQSKL----LDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDP 239 + NQVE P ++Q L LD + I +A S LG R L+ D L ++ Sbjct: 177 FTLATNQVEISP-VHQPLLLDGTLDQLQQLRIRPMAWSCLGGGR--LFNDEAYQPLRQE- 232 Query: 240 VLCALAKKHKQTP-ALIALRYQLQRGVVVLA--KSYNEQRIRENIQVFEFQLTSEDMKVL 296 L +A++ + + + L+ L S +R+R ++ LT + + Sbjct: 233 -LSVIAQELNASSIEQVVYAWILRLPSQPLPIIGSGKIERVRAALEAETLSLTRQQWFRI 291 Query: 297 DGLNRNY 303 Y Sbjct: 292 RKAALGY 298 >3N6Q-A nrPDB Length = 346 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 61/334 (18%), Positives = 127/334 (38%), Gaps = 71/334 (21%) Query: 12 DGHFMPVLGFGTYA--PPEVPRNRAVEVTKLAIEAGFRHIDSAYLYN-----NEEQVGLA 64 G +P L G + + + A + G H D A Y EE G Sbjct: 21 SGLRLPALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPPPGSAEENFGRL 80 Query: 65 IRSKIADGSVKREDIFYTSK----LWCTFFQPQMVQP----ALESSLKKLQLDYVDLYLL 116 +R A R+++ ++K +W + + +L+ SLK++ L+YVD++ Sbjct: 81 LREDFAAY---RDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYS 137 Query: 117 HFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQ---- 172 H + + + T + +G A +G+S+++ + Sbjct: 138 HR-------------------VDENTPMEETASALAHAVQSGKALYVGISSYSPERTQKM 178 Query: 173 --LEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQ-------- 222 L P L ++P N + ++++S LLD ++ + +A + L Sbjct: 179 VELLREWKIPLLIHQPSYNL--LNRWVDKSGLLDTLQNNGVGCIAFTPLAQGLLTGKYLN 236 Query: 223 ---------RHKLWVDPNSPVLLEDP------VLCALAKKHKQTPALIALRYQL--QRGV 265 R V +P +L + +L +A++ Q+ A +AL + L R Sbjct: 237 GIPQDSRMHREGNKVRGLTPKMLTEANLNSLRLLNEMAQQRGQSMAQMALSWLLKDDRVT 296 Query: 266 VVLAKSYNEQRIRENIQ-VFEFQLTSEDMKVLDG 298 VL + +++ EN+Q + +++++ +D Sbjct: 297 SVLIGASRAEQLEENVQALNNLTFSTKELAQIDQ 330 >3EB3-A nrPDB Length = 327 Score = 108 bits (270), Expect = 3e-24, Method: Composition-based stats. Identities = 68/338 (20%), Positives = 128/338 (37%), Gaps = 66/338 (19%) Query: 12 DGHFMPVLGFGTYAP--PEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRSKI 69 G + LG GT+ ++ A + LA + G D+A +Y + + + + I Sbjct: 11 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAE-VVLGNII 69 Query: 70 ADGSVKREDIFYTSKLWCTF-------FQPQMVQPALESSLKKLQLDYVDLYLLHFPMAL 122 +R + T+K++ + + L++SL++LQL+YVD+ + P Sbjct: 70 KKKGWRRSSLVITTKIFAGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPN 129 Query: 123 KPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGL 182 P E T M + G+A G S ++ ++ + Sbjct: 130 TPMEE-------------------TVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQ 170 Query: 183 --KYKPVCNQVECHPYLNQSK----LLDFCKSKDIVLVAHSALG----TQRHKLWVDPNS 232 P+C Q E H + K L + + + S L + ++ + P S Sbjct: 171 FNLIPPICEQAEYH-MFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYS 229 Query: 233 PVL------LEDPVLC--------------ALAKKHKQTPALIALRYQLQ-RGV-VVLAK 270 L+D +L A+A++ T +A+ + L+ GV VL Sbjct: 230 RASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLG 289 Query: 271 SYNEQRIREN---IQVFEFQLTSEDMKVLDGLNRNYRY 305 + N +++ EN IQV +L+S + +D + N Y Sbjct: 290 ASNAEQLMENIGAIQVLP-KLSSSIVHEIDSILGNKPY 326 >1OG6-A nrPDB Length = 298 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 57/307 (18%), Positives = 107/307 (34%), Gaps = 54/307 (17%) Query: 21 FGTYAPPE--VPRNRAVEVTKLAIEAGFRHIDSAYLYNN---EEQVGLAIRSKIADGSVK 75 G + + + + V + ++ G +D A +Y E G A++ Sbjct: 19 MGYWRLMDWNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALKLAPHL---- 74 Query: 76 REDIFYTSK------------LWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALK 123 RE + SK + + + E SL L D++DL L+H P L Sbjct: 75 RERMEIVSKCGIATTAREENVIGHYITDRDHIIKSAEQSLINLATDHLDLLLIHRPDPLM 134 Query: 124 PGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLK 183 + + + +G + GVSNF Q ++ ++ L Sbjct: 135 DADEVA-------------------DAFKHLHQSGKVRHFGVSNFTPAQFALLQSR--LP 173 Query: 184 YKPVCNQVECHPYLNQSKL----LDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDP 239 + NQVE P ++Q L LD + + +A S LG R + + L D Sbjct: 174 FTLATNQVEISP-VHQPLLLDGTLDQLQQLRVRPMAWSCLGGGR---LFNDDYFQPLRDE 229 Query: 240 VLCALAKKHKQ-TPALIALRYQLQRGVVVLA--KSYNEQRIRENIQVFEFQLTSEDMKVL 296 L +A++ + + + L+ L S +R+R ++ ++T + + Sbjct: 230 -LAVVAEELNAGSIEQVVNAWVLRLPSQPLPIIGSGKIERVRAAVEAETLKMTRQQWFRI 288 Query: 297 DGLNRNY 303 Y Sbjct: 289 RKAALGY 295 >4EXA-A nrPDB Length = 292 Score = 60.8 bits (146), Expect = 9e-10, Method: Composition-based stats. Identities = 51/260 (19%), Positives = 94/260 (36%), Gaps = 58/260 (22%) Query: 12 DGHFMPVLGFGTYAPPEV------------PRNRAVEVTKLAIEAGFRHIDSAYLYN-NE 58 G + LG GT A ++ LA + G ID+A Y +E Sbjct: 38 TGLAVSPLGLGTVKFGRDQGVKYPSGFTIPDDREAADLLALARDLGINLIDTAPAYGRSE 97 Query: 59 EQVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMV--------QPALESSLKKLQLDY 110 E++G +R +RE SK+ F Q V + ++E SLK+L+ D Sbjct: 98 ERLGPLLR-------GQREHWVIVSKVGEEFVDGQSVFDFSAAHTRRSVERSLKRLETDR 150 Query: 111 VDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNC 170 ++L L+H +G + D ++ S + + K GL + G+S Sbjct: 151 IELVLVH---------------SDGNDL-DILENSEVYPTLAALKREGLIGAYGLSGKTV 194 Query: 171 RQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDF--CKSKDIVL-----VAHSALGTQR 223 L + N E + ++++ +K I++ H+ LG + Sbjct: 195 EGGLRALREGDCAMV-TYNLNE----RAERPVIEYAAAHAKGILVKKALASGHACLGAGQ 249 Query: 224 HKLWVDPNSPVLLEDPVLCA 243 + ++ + P + A Sbjct: 250 DPVRASFE--LVFDQPGVAA 267 >1T6J-A nrPDB Length = 716 Score = 36.1 bits (82), Expect = 0.022, Method: Composition-based stats. Identities = 33/139 (23%), Positives = 49/139 (35%), Gaps = 15/139 (10%) Query: 112 DLYLLHFPMALKPGETPLPK---DENGKVIFDTVDLSATWEV--MEKCKDAGLAKSIGVS 166 DL H + ++ G++ D K + A MEK GLA+ IG Sbjct: 378 DLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEK-TRLGLAQ-IGKL 435 Query: 167 NFNCRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKL 226 NF QL +LN + P C E L CK DI A+++ Sbjct: 436 NFT--QLTEMLNAGMNRGLPSCLAAE------DPSLSYHCKGLDIAAAAYTSELGHLANP 487 Query: 227 WVDPNSPVLLEDPVLCALA 245 P + + + +LA Sbjct: 488 VTTHVQPAEMANQAVNSLA 506 >4EHI-A nrPDB Length = 534 Score = 31.9 bits (71), Expect = 0.36, Method: Composition-based stats. Identities = 8/18 (44%), Positives = 13/18 (72%) Query: 46 FRHIDSAYLYNNEEQVGL 63 F+HID ++Y N ++VG Sbjct: 383 FKHIDGGFVYQNSDEVGE 400 >2PTS-A nrPDB Length = 462 Score = 31.5 bits (70), Expect = 0.58, Method: Composition-based stats. Identities = 45/273 (16%), Positives = 86/273 (31%), Gaps = 64/273 (23%) Query: 97 PALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKD 156 L LK L + Y D+ LL + G+ P ++ + + + + + Sbjct: 148 RQLIDGLKDLAVQYRDIPLL----SRTHGQPATPSTIGKEMANVAYRMERQYRQLNQVEI 203 Query: 157 AGLAK-SIGVSNFNC--------RQL-EMILNKPGLKYKPVCNQVECHPYLN-------- 198 G ++G N + Q E + G+++ P Q+E H Y+ Sbjct: 204 LGKINGAVGNYNAHIAAYPEVDWHQFSEEFVTSLGIQWNPYTTQIEPHDYIAELFDCVAR 263 Query: 199 -QSKLLDF------------CKSKDIVLVAHSALGTQRHKL--WVDPNSPVLLEDPVLCA 243 + L+DF K K I S+ + + + + L + VL Sbjct: 264 FNTILIDFDRDVWGYIALNHFKQKTIAGEIGSSTMPHKVNPIDFENSEGNLGLSNAVLQH 323 Query: 244 LAKKHKQTPALIALRYQLQR-------------GVVVLAKSYNEQRIRENIQVFEFQLTS 290 LA K + R+Q G ++A + V + ++ Sbjct: 324 LASKLPVS------RWQRDLTDSTVLRNLGVGIGYALIAYQSTLK------GVSKLEVNR 371 Query: 291 EDMKVLDGLNRNYRYVVMDFLMDHPDYPFSDEY 323 + + LD L+ N+ + Y Y Sbjct: 372 DHL--LDELDHNWEVLAEPIQTVMRRYGIEKPY 402 >3VS9-A nrPDB Length = 410 Score = 31.1 bits (69), Expect = 0.75, Method: Composition-based stats. Identities = 17/113 (15%), Positives = 31/113 (27%), Gaps = 10/113 (8%) Query: 207 KSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVV 266 + + L A+ + + + K+ +PA I QR +V Sbjct: 27 QRITLELTAYGFARAHCLSNGITDEEGFVQVYKTVKEKFDKYAVSPAQI-----KQRQLV 81 Query: 267 VLAKSYNEQRIRE-NIQVFEFQLTSEDMKVLDGLNRNYRYVVMDFLMDHPDYP 318 K + R + N + + D L + D H Y Sbjct: 82 YFPK-LTDIRFGDGNFDIAD---PEPDQAHLRLFDIKKDPRGADLKTRHESYA 130 >4FO0-A nrPDB Length = 593 Score = 29.9 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 12/64 (18%), Positives = 25/64 (39%), Gaps = 8/64 (12%) Query: 86 W-CTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDL 144 W T P+ + + L ++ +D Y +H+P+ G+ + G + D+ Sbjct: 125 WTNTSHHPEYLVGE-----EALYVNPLDCYNIHWPIR--RGQLNIHPGPGGSLTAVLADI 177 Query: 145 SATW 148 W Sbjct: 178 EVIW 181 >4Y0A-A nrPDB Length = 179 Score = 29.9 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 12/43 (27%), Positives = 24/43 (55%), Gaps = 1/43 (2%) Query: 198 NQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVL-LEDP 239 Q+ +F K + IV+ ++ + Q + + D N P+L +E+P Sbjct: 90 TQAPNREFLKQRGIVVYLYTPVELQLQRTYRDKNRPLLQVENP 132 >5ZF1-A nrPDB Length = 301 Score = 29.6 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 9/23 (39%), Positives = 15/23 (65%) Query: 193 CHPYLNQSKLLDFCKSKDIVLVA 215 CH Y + KL +C++ DI++ A Sbjct: 197 CHRYTPKDKLEAYCRNADIIITA 219 >4L1C-A nrPDB Length = 103 Score = 29.6 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 17/70 (24%), Positives = 26/70 (37%), Gaps = 1/70 (1%) Query: 116 LHFPMALKPGETP-LPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLE 174 +H + K + P K + ++ W M K A + IGVS QL+ Sbjct: 30 IHQALEDKIAQAPAFLKHAPVVLNVSALEDPVNWSAMHKAVSATGLRVIGVSGCKDAQLK 89 Query: 175 MILNKPGLKY 184 + K GL Sbjct: 90 AEIEKMGLPI 99 >3MMA-A nrPDB Length = 418 Score = 28.4 bits (62), Expect = 4.3, Method: Composition-based stats. Identities = 13/65 (20%), Positives = 22/65 (33%), Gaps = 4/65 (6%) Query: 89 FFQPQMVQPALESSLK---KLQLDYVD-LYLLHFPMALKPGETPLPKDENGKVIFDTVDL 144 P + + A +L+ L + Y D L+ +P K P D + Sbjct: 176 CMGPALCEFACYDTLELCYDLTMTYQDELHRPMWPYKFKIKCAGCPNDCVASKARSDFAI 235 Query: 145 SATWE 149 TW+ Sbjct: 236 IGTWK 240 >6ET0-A nrPDB Length = 365 Score = 28.0 bits (61), Expect = 6.3, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 17/36 (47%), Gaps = 2/36 (5%) Query: 89 FFQPQMVQPALESSLKK--LQLDYVDLYLLHFPMAL 122 F P V A+ +L+K L D +D ++ H P Sbjct: 256 SFVPTNVPIAMRRALEKAGLGSDDIDYFVFHQPAPF 291 >4MKI-B nrPDB Length = 298 Score = 27.6 bits (60), Expect = 7.0, Method: Composition-based stats. Identities = 11/41 (26%), Positives = 17/41 (41%) Query: 152 EKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYKPVCNQVE 192 E ++A + IG+S L L K G+ P +E Sbjct: 234 EVFREAERLEKIGLSVPQITSLARELRKRGVPIPPDVLTIE 274 >4A2N-B nrPDB Length = 194 Score = 27.6 bits (60), Expect = 7.3, Method: Composition-based stats. Identities = 16/92 (17%), Positives = 29/92 (31%), Gaps = 13/92 (14%) Query: 88 TFFQPQMVQPALESSLKKLQL-------------DYVDLYLLHFPMALKPGETPLPKDEN 134 + V+P E SL L Y+D + ++ P +++ + Sbjct: 30 KNKSKKKVRPNFEKSLVFLNFIGMVFLPLTAVFSSYLDSFNINLPDSIRLFALIVTFLNI 89 Query: 135 GKVIFDTVDLSATWEVMEKCKDAGLAKSIGVS 166 G DL W + + KD G+ Sbjct: 90 GLFTKIHKDLGNNWSAILEIKDGHKLVKEGIY 121 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.142 0.427 Lambda K H 0.267 0.0437 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,132,680 Number of Sequences: 36641 Number of extensions: 601696 Number of successful extensions: 2063 Number of sequences better than 10.0: 65 Number of HSP's better than 10.0 without gapping: 109 Number of HSP's successfully gapped in prelim test: 21 Number of HSP's that attempted gapping in prelim test: 1630 Number of HSP's gapped (non-prelim): 130 length of query: 323 length of database: 10,336,785 effective HSP length: 97 effective length of query: 226 effective length of database: 6,782,608 effective search space: 1532869408 effective search space used: 1532869408 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 59 (27.2 bits)