BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P17315 (663 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2HDF-A nrPDB 1304 0.0 5FP2-A nrPDB 317 1e-86 5M9B-A nrPDB 295 3e-80 5FR8-A nrPDB 276 2e-74 1FEP-A nrPDB 267 9e-72 1NQH-A nrPDB 160 2e-39 3FHH-A nrPDB 102 8e-22 3QLB-A nrPDB 74 1e-13 4EPA-A nrPDB 65 8e-11 1XKH-A nrPDB 59 8e-09 1FCP-A nrPDB 59 9e-09 2W78-A nrPDB 58 1e-08 5FP1-A nrPDB 57 2e-08 6FOK-A nrPDB 57 2e-08 1KMO-A nrPDB 55 8e-08 6BPM-C nrPDB 54 3e-07 5FOK-A nrPDB 52 8e-07 5NEC-A nrPDB 51 2e-06 4RDT-A nrPDB 46 5e-05 3EFM-A nrPDB 44 3e-04 1XKW-A nrPDB 42 6e-04 3V8X-A nrPDB 42 7e-04 6E4V-A nrPDB 42 0.001 3CSL-A nrPDB 40 0.002 5FQ8-B nrPDB 35 0.11 4ZGV-A nrPDB 31 1.9 6H7F-A nrPDB 29 5.6 >2HDF-A nrPDB Length = 639 Score = 1304 bits (3374), Expect = 0.0, Method: Compositional matrix adjust. Identities = 634/639 (99%), Positives = 637/639 (99%) Query: 25 AVDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGD 84 +VDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGD Sbjct: 1 SVDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGD 60 Query: 85 NRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLY 144 NRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLY Sbjct: 61 NRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLY 120 Query: 145 GSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAY 204 GSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAY Sbjct: 121 GSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAY 180 Query: 205 GSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFDRQDRDS 264 GSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFDRQDRDS Sbjct: 181 GSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFDRQDRDS 240 Query: 265 DSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPITSESNTVDGKYTLP 324 DSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPITSESNTVDGKYTLP Sbjct: 241 DSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPITSESNTVDGKYTLP 300 Query: 325 LTAINQFLTVGGEWRHDKLSDAVNLTGGTSSKTSASQYALFVEDEWRIFEPLALTTGVRM 384 LTAINQFLTVGGE RHDK+SDAVNLTGGTSSKTSASQYALFVEDEWRIFEPLALTTGVRM Sbjct: 301 LTAINQFLTVGGEMRHDKMSDAVNLTGGTSSKTSASQYALFVEDEWRIFEPLALTTGVRM 360 Query: 385 DDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGS 444 DDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGS Sbjct: 361 DDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGS 420 Query: 445 PDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFV 504 PDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFV Sbjct: 421 PDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFV 480 Query: 505 GFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKP 564 GFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKP Sbjct: 481 GFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKP 540 Query: 565 LSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVT 624 LSDLPFHTANGTLDWKPLALEDWS Y+SGHYTGQKRADSATAKTPGGYTIWNTGAAWQVT Sbjct: 541 LSDLPFHTANGTLDWKPLALEDWSMYMSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVT 600 Query: 625 KDVKLRAGVLNLGDKDLSRDDYSYNEDGRRYFMAVDYRF 663 KDVKLRAGVLNLGDKDLSRDDYSYNEDGRRYFMAVDYRF Sbjct: 601 KDVKLRAGVLNLGDKDLSRDDYSYNEDGRRYFMAVDYRF 639 >5FP2-A nrPDB Length = 725 Score = 317 bits (811), Expect = 1e-86, Method: Compositional matrix adjust. Identities = 250/724 (34%), Positives = 355/724 (49%), Gaps = 126/724 (17%) Query: 35 VTASSVEQNLKDAPASISVITQEDL-QRKPVQNLKDVLKEVPGVQLT------NEGDNRK 87 V + EQ LK AP +S+IT ED+ +R PV +L ++++ +PGV LT G+NR+ Sbjct: 25 VVLGTAEQELKQAPG-VSIITAEDIRKRPPVNDLSEIIRTMPGVNLTGNSSSGQRGNNRQ 83 Query: 88 GVSIRGLDSSYTLILVDGKRVNSRNAVF------RHNDFDLNWIPVDSIERIEVVRGPMS 141 + IRG+ TLILVDGK V+SRN+V R D NW+P + +ERIEV+RGP + Sbjct: 84 -IDIRGMGPENTLILVDGKPVSSRNSVRYGWRGERDTRGDSNWVPPEEVERIEVLRGPAA 142 Query: 142 SLYGSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGM 201 + YGS A GGVVNIITK+ + G++TV T I E G T F SGPL + L Sbjct: 143 ARYGSGAAGGVVNIITKRPTDRLRGSMTVFTNIPESSKDGATRRANFSLSGPLTE-ALSF 201 Query: 202 KAYGSLAKREKDDPQ-------NSTTTDTGETPRIEGFSSRDGNVEFAW--TPNQNHDFT 252 +AYGS K + DD N + T G EG +RD + +W TP+Q DF Sbjct: 202 RAYGSANKTDSDDTDINLGHTVNPSRTVAGR----EGVRNRDLSGMLSWQVTPDQVVDFE 257 Query: 253 AG-------YGFDRQDRDS---------DSLDKNRLERQNYSVSHNGRWDYGTSEL---- 292 AG Y D Q+ + D + NR+ R+NY+++HNG W +GTS Sbjct: 258 AGFSRQGNIYAGDTQNNNGTANTQGLADDGAETNRMYRENYAITHNGTWSFGTSRFVAQY 317 Query: 293 ---------KYYGEKVENKNPGNSSPITS--ESNTVDGKYTLPLTAI-NQFLTVGGEWRH 340 + VE + + S S E+ + G+ LPL A+ Q LTVG EW Sbjct: 318 DSTRNNRLEEGLAGSVEGQIGADRSFSASKLENYRLSGELNLPLHALFEQVLTVGAEWNK 377 Query: 341 DKLSDAVNL---------------TGGTSSKTSASQYALFVEDEWRIFEPLALTTGVRMD 385 + L+D +L G S K+ A AL+VED + LT G+R+D Sbjct: 378 ETLNDPSSLKQGFVGSDSLPGTPAAGSRSPKSKAEIRALYVEDNIELRPGTMLTPGLRLD 437 Query: 386 DHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWT----SNSC-----R 436 DH +G +WSP + TVK G A AFKAP+L Q +P++ N C Sbjct: 438 DHSDFGLNWSPSLNASQTLGEYFTVKAGIARAFKAPNLYQSNPNYLLYTRGNGCPIQTSS 497 Query: 437 GACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNA 496 G C +VG+ +L ETS + ELG+ + +GW+ G +T FRND K++I DV Sbjct: 498 GGCYLVGNENLDAETSVNKELGIEFR-RDGWVAG----LTYFRNDYKNKIVAPL--DVMG 550 Query: 497 APGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYN-DGR 555 G TG N + + N KA ++G+E L +P +++ S N TY + Sbjct: 551 QTG--------TGNN-----ILQWSNAKKAVVEGLEGNLLVPLHEDLSWSTNLTYMLQSK 597 Query: 556 DVSNGENKPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADS---------ATA 606 D G PLS +P +T N TLDW+ A E S ++ G++ + Sbjct: 598 DKDTG--NPLSVIPEYTLNSTLDWQ--ASERLSTQLTSTIYGRQEPPKHGTSRNTPVVSR 653 Query: 607 KTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRDDYS-------YNEDGRRYFMAV 659 K G Y IW A + ++++ +R GV NL DK L R S YNE GR Y++++ Sbjct: 654 KEVGTYGIWGVSAGYTFSENLSVRGGVSNLFDKRLYRQGNSFDAGAATYNEPGRAYYVSM 713 Query: 660 DYRF 663 F Sbjct: 714 TTSF 717 >5M9B-A nrPDB Length = 724 Score = 295 bits (756), Expect = 3e-80, Method: Compositional matrix adjust. Identities = 240/741 (32%), Positives = 361/741 (48%), Gaps = 128/741 (17%) Query: 25 AVDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQN-LKDVLKEVPGVQLT--- 80 +V + GE VV ++ ++ K AP +S+IT ED+ ++P N L +++ +PGV LT Sbjct: 10 SVIELGEQTVV--ATAQEETKQAPG-VSIITAEDIAKRPPSNDLSQIIRTMPGVNLTGNS 66 Query: 81 ---NEGDNRKGVSIRGLDSSYTLILVDGKRVNSRNAVF------RHNDFDLNWIPVDSIE 131 G+NR+ + IRG+ TLILVDGK V+SRN+V R + D NW+P D +E Sbjct: 67 SSGQRGNNRQ-IDIRGMGPENTLILVDGKPVSSRNSVRYGWRGERDSRGDTNWVPADQVE 125 Query: 132 RIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTS 191 RIEV+RGP ++ YG+ A GGVVNIITK+ G + G ++V + +H+ G + F + Sbjct: 126 RIEVIRGPAAARYGNGAAGGVVNIITKQAGAETHGNLSVYSNFPQHKAEGASERMSFGLN 185 Query: 192 GPLIDGVLGMKAYGSLAKREKDD-------PQNSTTTDTGETPR-IEGFSSRDGNVEFAW 243 GPL + L + YG++AK + DD N T G P EG ++D + +W Sbjct: 186 GPLTEN-LSYRVYGNIAKTDSDDWDINAGHESNRTGKQAGTLPAGREGVRNKDIDGLLSW 244 Query: 244 --TPNQNHDFTAG-------YGFDRQDRDSDSLDK-------NRLERQNYSVSHNGRWDY 287 TP Q +F AG Y D Q+ +S++ K NR+ R+ YSV+H G WD+ Sbjct: 245 RLTPEQTLEFEAGFSRQGNIYTGDTQNTNSNNYVKQMLGHETNRMYRETYSVTHRGEWDF 304 Query: 288 GTSELKYYGEKVENK--------------NPGNSSPITSESN--TVDGKYTLPL-TAINQ 330 G+S EK N +P N+ T+ T G+ LPL Q Sbjct: 305 GSSLAYLQYEKTRNSRINEGLAGGTEGIFDPNNAGFYTATLRDLTAHGEVNLPLHLGYEQ 364 Query: 331 FLTVGGEWRHDKLSDAVNLTGGTSSKTS--------------ASQYALFVEDEWRIFEPL 376 LT+G EW KL D + T T S A ++LF ED + Sbjct: 365 TLTLGSEWTEQKLDDPSSNTQNTEEGGSIPGLAGKNRSSSSSARIFSLFAEDNIELMPGT 424 Query: 377 ALTTGVRMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWT----S 432 LT G+R D H+ G++WSP L + T+ VT+K G A A+KAP+L QL+PD+ Sbjct: 425 MLTPGLRWDHHDIVGDNWSPSLNLSHALTERVTLKAGIARAYKAPNLYQLNPDYLLYSRG 484 Query: 433 NSCRG---ACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISIS 489 C G +C + G+ LK ETS + ELG+ Y +G+ + +T FRND K++I Sbjct: 485 QGCYGQSTSCYLRGNDGLKAETSVNKELGIEYS-----HDGLVAGLTYFRNDYKNKIESG 539 Query: 490 RTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINY 549 + +A+ G ++ ++ + NV KA ++G+E L +P D K S N Sbjct: 540 LSPVDHASGGKGDYA---------NAAIYQWENVPKAVVEGLEGTLTLPLADGLKWSNNL 590 Query: 550 TYNDGRDVSNGENKPLSDL----PFHTANGTLDWKPLALEDWSFYVSGHYTGQ---KRAD 602 TY + +NK D+ P +T N LDW+ A +D S + + G+ K+ D Sbjct: 591 TY-----MLQSKNKETGDVLSVTPRYTLNSMLDWQ--ATDDLSLQATVTWYGKQKPKKYD 643 Query: 603 SATAKTPGG-------YTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSR------------ 643 + G Y I G ++++K++ L AGV NL DK L R Sbjct: 644 YHGDRVTGSANDQLSPYAIAGLGGTYRLSKNLSLGAGVDNLFDKRLFRAGNAQGVVGIDG 703 Query: 644 -DDYSYNEDGRRYFMAVDYRF 663 +YNE GR ++ ++ F Sbjct: 704 AGAATYNEPGRTFYTSLTASF 724 >5FR8-A nrPDB Length = 733 Score = 276 bits (707), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 234/728 (32%), Positives = 345/728 (47%), Gaps = 114/728 (15%) Query: 31 ETMVVTAS-SVEQNLKDAPASISVITQEDLQRKPVQN-LKDVLKEVPGVQLT------NE 82 ET+ VTA V+Q+L +SVIT+EDL++ PV+N + D ++ +PGV LT Sbjct: 25 ETIFVTAEEQVKQSL-----GVSVITKEDLEKLPVRNDISDYVRRMPGVNLTGNSATGQR 79 Query: 83 GDNRKGVSIRGLDSSYTLILVDGKRVNSRNAVF------RHNDFDLNWIPVDSIERIEVV 136 G+NR+ + IRG+ TLILVDGK +NSRN+V R D NW+P ++IE IEV+ Sbjct: 80 GNNRQ-IDIRGMGPENTLILVDGKPINSRNSVRYGWKGERDTRGDSNWVPAEAIESIEVL 138 Query: 137 RGPMSSLYGSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLID 196 RGP ++ YGS A GGVVNIITKK+ + G+V T+ E G + F SGPLI Sbjct: 139 RGPAAARYGSGAAGGVVNIITKKVTNETHGSVEFYTSQPEDSKEGSSNRVGFNVSGPLIK 198 Query: 197 GVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNH----DFT 252 VL + YG+ K E DD + + + R EG ++D + AW D + Sbjct: 199 DVLSYRLYGNYNKTEADDVDINKSIGSTAAGR-EGVKNKDISGRLAWQATDQQTVLLDIS 257 Query: 253 AG-----YGFDRQ---DRDSDSL-------DKNRLERQNYSVSHNGRWDYGTSELKYYGE 297 + Y D Q + ++D++ + N + R +Y+++H G W +G S+L + Sbjct: 258 SSKQGNIYSGDSQLNANAEADAILSQLIGKETNTMYRDSYALTHEGDWSWGKSKLVAQYD 317 Query: 298 KVENKN--PGNSSPITSESNTVDGKYTLPLTAIN--------------QFLTVGGEWRHD 341 K NK G + + + N +D K T L + Q LTVG EW D Sbjct: 318 KTHNKRLPEGLAGSVEGKINNLDDKATSRLETLRFNGEANIPFEYYLPQVLTVGTEWVED 377 Query: 342 KLSDAVN---------------LTGGTSSKTSASQYALFVEDEWRIFEPLALTTGVRMDD 386 + D V+ L G SK + + ++ED ++ + + G+R DD Sbjct: 378 RFKDNVSTTQGKDSSGSGYGDQLAKGDRSKMESRIASAYIEDNLKVTDSTDVVLGLRFDD 437 Query: 387 HETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDW----TSNSC----RGA 438 H G +WSP + D T+KGG A A+KAP++ Q + + N C Sbjct: 438 HSKSGSNWSPSLNITQKLNDYFTLKGGVAKAYKAPNMYQNAEGYLLSTNGNGCPANIESR 497 Query: 439 CKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAP 498 C + G+ DLKPETS + ELG+ + + V +S+T FRND KD+I ++ T V Sbjct: 498 CLLQGNGDLKPETSVNKELGIQFQKDI-----VNASLTWFRNDYKDKI-VAGTHVVGTVD 551 Query: 499 GYQNFVGFETGA-NGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTY-NDGRD 556 G + TGA + + + N KA IQG E L + F D + + N+TY D +D Sbjct: 552 G--SSTNANTGAVTNTKWNILRWENTPKALIQGFEGSLGLDFGD-IRWTNNFTYMMDSKD 608 Query: 557 VSNGENKPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTPGG----- 611 G PLS +P +T N D+ D +F V Y QK A + G Sbjct: 609 KQTG--NPLSLVPIYTINSIFDYDITDQLDVNF-VFTQYGRQKSRQFAENRLESGIGSGG 665 Query: 612 ------------YTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRDDYS----YNEDGRRY 655 Y+ ++ + + R GV NL DK + RD S YNE GR Y Sbjct: 666 ANSALKPSTVKSYSTAGINVGYKFSDQISTRVGVSNLFDKQILRDSNSISQTYNEPGRAY 725 Query: 656 FMAVDYRF 663 + ++ Y F Sbjct: 726 YASLKYSF 733 >1FEP-A nrPDB Length = 724 Score = 267 bits (683), Expect = 9e-72, Method: Compositional matrix adjust. Identities = 242/746 (32%), Positives = 356/746 (47%), Gaps = 146/746 (19%) Query: 31 ETMVVTASSVEQNLKDAPASISVITQEDLQRKPV-QNLKDVLKEVPGVQLT------NEG 83 +T+VVTA+ EQNL+ AP +S IT +++++ PV +++ +++ +PGV LT G Sbjct: 12 DTIVVTAA--EQNLQ-APG-VSTITADEIRKNPVARDVSKIIRTMPGVNLTGNSTSGQRG 67 Query: 84 DNRKGVSIRGLDSSYTLILVDGKRVNSRNAVF------RHNDFDLNWIPVDSIERIEVVR 137 +NR+ + IRG+ TLIL+DGK V+SRN+V R D +W+P + IERIEV+R Sbjct: 68 NNRQ-IDIRGMGPENTLILIDGKPVSSRNSVRQGWRGERDTRGDTSWVPPEMIERIEVLR 126 Query: 138 GPMSSLYGSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDG 197 GP ++ YG+ A GGVVNIITKK +W G+ EH++ G T F +GPL D Sbjct: 127 GPAAARYGNGAAGGVVNIITKKGSGEWHGSWDAYFNAPEHKEEGATKRTNFSLTGPLGD- 185 Query: 198 VLGMKAYGSLAKREKD--------DPQNSTTTDTGETPRIEGFSSRD--GNVEFAWTPNQ 247 + YG+L K + D + T T EG ++D G V + + P Q Sbjct: 186 EFSFRLYGNLDKTQADAWDINQGHQSARAGTYATTLPAGREGVINKDINGVVRWDFAPLQ 245 Query: 248 NHDFTAG-------YGFDRQDRDSDSLDK-------NRLERQNYSVSHNGRWDYG--TSE 291 + + AG Y D Q+ +SDS + NRL RQNY+++ NG WD G TS Sbjct: 246 SLELEAGYSRQGNLYAGDTQNTNSDSYTRSKYGDETNRLYRQNYALTWNGGWDNGVTTSN 305 Query: 292 LKYYGEKVENKNP----GNSSPITSESNTVD------------GKYTLPLT-AINQFLTV 334 Y ++ P G + +E T D + LP+ +NQ LT+ Sbjct: 306 WVQYEHTRNSRIPEGLAGGTEGKFNEKATQDFVDIDLDDVMLHSEVNLPIDFLVNQTLTL 365 Query: 335 GGEWRHDKLSDAVN----LTG--------GTSSK-----TSASQYALFVEDEWRIFEPLA 377 G EW ++ D + LTG G S+ + A ++LF E+ + + Sbjct: 366 GTEWNQQRMKDLSSNTQALTGTNTGGAIDGVSTTDRSPYSKAEIFSLFAENNMELTDSTI 425 Query: 378 LTTGVRMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWT----SN 433 +T G+R D H G +WSP + D T+K G A A+KAPSL Q +P++ Sbjct: 426 VTPGLRFDHHSIVGNNWSPALNISQGLGDDFTLKMGIARAYKAPSLYQTNPNYILYSKGQ 485 Query: 434 SC---RGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISR 490 C G C + G+ DLK ETS + E+GL + +GWL G VT FRND +++I Sbjct: 486 GCYASAGGCYLQGNDDLKAETSINKEIGLEFK-RDGWLAG----VTWFRNDYRNKIE--- 537 Query: 491 TSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYT 550 GY G N ++ + NV KA ++G+E L +P ++ + N T Sbjct: 538 -------AGY-----VAVGQNAVGTDLYQWDNVPKAVVEGLEGSLNVPVSETVMWTNNIT 585 Query: 551 YNDGRDVSNGENKP----LSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKR------ 600 Y + ENK LS +P +T N TL W+ A ED S + + G+++ Sbjct: 586 Y-----MLKSENKTTGDRLSIIPEYTLNSTLSWQ--AREDLSMQTTFTWYGKQQPKKYNY 638 Query: 601 ----ADSATAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSR------------- 643 A K Y+I A W VTK+V L GV NL DK L R Sbjct: 639 KGQPAVGPETKEISPYSIVGLSATWDVTKNVSLTGGVDNLFDKRLWRAGNAQTTGDLAGA 698 Query: 644 ------DDYSYNEDGRRYFMAVDYRF 663 Y+YNE GR ++M+V+ F Sbjct: 699 NYIAGAGAYTYNEPGRTWYMSVNTHF 724 >1NQH-A nrPDB Length = 594 Score = 160 bits (404), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 177/680 (26%), Positives = 283/680 (41%), Gaps = 130/680 (19%) Query: 27 DDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNR 86 D +T+VVTA+ EQ A +V+T++D+ R ++ DVL+ +PGV +T G + Sbjct: 2 DTSPDTLVVTANRFEQPRSTVLAPTTVVTRQDIDRWQSTSVNDVLRRLPGVDITQNGGSG 61 Query: 87 K--GVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLY 144 + + IRG ++S+ L+L+DG R+N DL+ P+ ++R+E +RGP S++Y Sbjct: 62 QLSSIFIRGTNASHVLVLIDGVRLNLAGV---SGSADLSQFPIALVQRVEYIRGPRSAVY 118 Query: 145 GSDALGGVVNIITKK------IGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGV 198 GSDA+GGVVNIIT + I W + + + GD G Sbjct: 119 GSDAIGGVVNIITTRDEPGTEISAGWGSNSYQNYDVSTQQQLGDKTRVTLLGDYAHTHG- 177 Query: 199 LGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFD 258 + AYG+ + + D + + + + N AW+ F GYG+D Sbjct: 178 YDVVAYGNTGTQAQTDNDGFLSKTL--------YGALEHNFTDAWS-----GFVRGYGYD 224 Query: 259 -RQDRD------SDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPIT 311 R + D S LD +L Q+ WD G L+Y GE ++ S IT Sbjct: 225 NRTNYDAYYSPGSPLLDTRKLYSQS--------WDAG---LRYNGELIK------SQLIT 267 Query: 312 SESNTVD-------GKY--TLPLTAINQFLTVGGEWRHDKLSDAVNLTGGTS-SKTSASQ 361 S S++ D G+Y + L + Q+ +W ++ + ++ G K + + Sbjct: 268 SYSHSKDYNYDPHYGRYDSSATLDEMKQYTV---QWANNVIVGHGSIGAGVDWQKQTTTP 324 Query: 362 YALFVEDEWRIFEPLALTTGV------------RMDDHETYGEHWSPRAYLVYNATDTVT 409 +VED + TG+ R DD+ +G H + + + + Sbjct: 325 GTGYVEDGYDQRNTGIYLTGLQQVGDFTFEGAARSDDNSQFGRHGTWQTSAGWEFIEGYR 384 Query: 410 VKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWLE 469 + T++KAP+L QL G+P+L PE S+ WE EG Sbjct: 385 FIASYGTSYKAPNLGQL------------YGFYGNPNLDPEKSKQWEGAF-----EGLTA 427 Query: 470 GVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQ 529 GV ++ +RNDV D I + YYN KARI+ Sbjct: 428 GVNWRISGYRNDVSDLIDYDDHT-------------------------LKYYNEGKARIK 462 Query: 530 GVETELKIPFNDEWKLSINYTYNDGRDVSNGENKPLSDLPFHTANGTLDWKPLALEDWSF 589 GVE +++Y Y D R+ + PL LDW+ L D+ + Sbjct: 463 GVEATANFD-TGPLTHTVSYDYVDARNAIT--DTPLLRRAKQQVKYQLDWQ---LYDFDW 516 Query: 590 YVSGHYTGQKRADSATAKTP------GGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSR 643 ++ Y G R D + P GG ++W+ A+ VT + +R + NL DKD Sbjct: 517 GITYQYLG-TRYDKDYSSYPYQTVKMGGVSLWDLAVAYPVTSHLTVRGKIANLFDKDY-E 574 Query: 644 DDYSYNEDGRRYFMAVDYRF 663 Y Y GR Y ++ Y F Sbjct: 575 TVYGYQTAGREYTLSGSYTF 594 >3FHH-A nrPDB Length = 640 Score = 102 bits (253), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 163/668 (24%), Positives = 279/668 (41%), Gaps = 116/668 (17%) Query: 31 ETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEG-DNRKGV 89 ETM VTA+ ++ +AP +SVI + + + D+L+ VPG+ L G N + + Sbjct: 2 ETMTVTATGNARSSFEAPMMVSVIDTSAPENQTATSATDLLRHVPGITLDGTGRTNGQDI 61 Query: 90 SIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDS--IERIEVVRGPMSSLYGSD 147 ++RG D L+LVDG R + LN +D I+R+E+VRGP + LYGS Sbjct: 62 NMRGYDHRGVLVLVDGIRQGTDTG-------HLNGTFLDPALIKRVEIVRGPSALLYGSG 114 Query: 148 ALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGM--KAYG 205 ALGGV++ TV +QE + G + F +G D LG+ A+G Sbjct: 115 ALGGVISY----------DTVDAKDLLQEGQSSG----FRVFGTGGTGDHSLGLGASAFG 160 Query: 206 ---------SLAKREKDDPQNSTTTDTGETP---------------RIEGFSSRDGNVEF 241 + + R++ D + S GET +I+ S G V + Sbjct: 161 RTENLDGIVAWSSRDRGDLRQS----NGETAPNDESINNMLAKGTWQIDSAQSLSGLVRY 216 Query: 242 ----AWTPNQNHDFTAGYGFDRQDRDSDSLDKNRLERQ---NYSVSHNGR-WDYGTSELK 293 A P A + + +D++ ++R +Y ++ G W +++ Sbjct: 217 YNNDAREPKNPQTVEA------SESSNPMVDRSTIQRDAQLSYKLAPQGNDWLNADAKIY 270 Query: 294 YYGEKVENKNPGNS----SPITSESNTVDGKYTLPLTAINQFLTVGGE-WRHDKLSDAVN 348 + ++ +N G+S IT + + + + LT GGE +R ++ S + Sbjct: 271 WSEVRINAQNTGSSGEYREQITKGARLENRSTLFADSFASHLLTYGGEYYRQEQGSHHHH 330 Query: 349 LTGGTSSKTSASQYAL-----FVEDEWRIFE-PLALTTGVRMDDH--------ETYGEHW 394 + T Q + +++DE + + P+ L G R D + + + W Sbjct: 331 HHHPGGATTGFPQAKIDFSSGWLQDEITLRDLPITLLGGTRYDSYRGSSDGYKDVDADKW 390 Query: 395 SPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSC-RGACKI-VGSPDLKPETS 452 S RA + N T+ + + G +A AF+AP++ ++ D S R V +P+L+PET+ Sbjct: 391 SSRAGMTINPTNWLMLFGSYAQAFRAPTMGEMYNDSKHFSIGRFYTNYWVPNPNLRPETN 450 Query: 453 ESWELGLYYMGEEGWL--EGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGA 510 E+ E G ++ L + +E + F KD IS T D AA Sbjct: 451 ETQEYGFGLRFDDLMLSNDALEFKASYFDTKAKDYIST--TVDFAAATTMS--------- 499 Query: 511 NGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKPLSDLPF 570 YNV A+I G + K D + L + Y G+D GE +S + Sbjct: 500 ----------YNVPNAKIWGWDVMTKYT-TDLFSLDVAYNRTRGKDTDTGEY--ISSINP 546 Query: 571 HTANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLR 630 T TL+ P+A +S G + + S++ GY + + ++Q + +K Sbjct: 547 DTVTSTLN-IPIAHSGFSVGWVGTFADRSTHISSSYSKQPGYGVNDFYVSYQGQQALKGM 605 Query: 631 AGVLNLGD 638 L LG+ Sbjct: 606 TTTLVLGN 613 >3QLB-A nrPDB Length = 748 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 54/169 (31%), Positives = 93/169 (55%), Gaps = 27/169 (15%) Query: 35 VTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRK--GVSIR 92 ++ + + +L + P SISVIT++ + + VQ++ + L+ GVQ +++ +SIR Sbjct: 89 LSGTKTDASLSEIPQSISVITRDQMDAQQVQSVNEALRYTAGVQANTTAASQRFDTLSIR 148 Query: 93 GLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDS--IERIEVVRGPMSSLYGSDALG 150 G D + T +L DG + N+ A W V++ +ERI+V++GP S L+G ++ G Sbjct: 149 GFDVT-TGMLRDGLKGNTAQA----------WPKVEAYGLERIDVLKGPASVLFGQNSPG 197 Query: 151 GVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYN---GQFFTSGPLID 196 GVVN I+K+ +D E + +G +++ GQF SGPL D Sbjct: 198 GVVNQISKR---------PLDKPFHEVQIQGGSFDRAQGQFDFSGPLDD 237 >4EPA-A nrPDB Length = 655 Score = 65.5 bits (158), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 64/232 (27%), Positives = 111/232 (47%), Gaps = 41/232 (17%) Query: 29 DGETMVVTASSVEQNLKDAPA---SISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDN 85 D T+VVTAS +Q+ + A A S +V++ +L V + + +PG+ + N G+ Sbjct: 10 DESTLVVTAS--KQSSRSASANNVSSTVVSAPELSDAGVTASDKLPRVLPGLNIENSGNM 67 Query: 86 R-KGVSIRGLDSSYTL------ILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRG 138 +S+RG+ S+ + VDG S N + D ++ +E++RG Sbjct: 68 LFSTISLRGVSSAQDFYNPAVTLYVDGVPQLSTNTIQALTD----------VQSVELLRG 117 Query: 139 PMSSLYGSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRG----DTYNGQFFTSGPL 194 P +LYG A GG++NI+T++ D+T + + + G D+Y +F SGP+ Sbjct: 118 PQGTLYGKSAQGGIINIVTQQ----------PDSTPRGYIEGGVSSRDSYRSKFNLSGPI 167 Query: 195 IDGVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPN 246 DG+L YGS+ + D + TG + + G + GNV+ P+ Sbjct: 168 QDGLL----YGSVTLLRQVDDGDMINPATG-SDDLGGTRASIGNVKLRLAPD 214 >1XKH-A nrPDB Length = 687 Score = 58.5 bits (140), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 41/163 (25%), Positives = 79/163 (48%), Gaps = 11/163 (6%) Query: 34 VVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRG 93 + TA+ + ++ P SI+V+T++++ + N+ DV++ PG+ ++ +R RG Sbjct: 24 IATATRLVLTPRETPQSITVVTRQNMDDFGLNNIDDVMRHTPGITVSAYDTDRNNYYARG 83 Query: 94 LDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVV 153 S DG +RN + + L+ + + +R+EV++G L G+ +LG + Sbjct: 84 F--SINNFQYDGIPSTARNVGYSAGN-TLSDMAI--YDRVEVLKGATGLLTGAGSLGATI 138 Query: 154 NIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLID 196 N+I KK ++ G V + D Y + SGPL + Sbjct: 139 NLIRKKPTHEFKGHVELGA------GSWDNYRSELDVSGPLTE 175 >1FCP-A nrPDB Length = 705 Score = 58.5 bits (140), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 37/133 (27%), Positives = 68/133 (51%), Gaps = 19/133 (14%) Query: 35 VTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGL 94 T + + ++ P SISV+T E++ +++K+ L PGV V RG Sbjct: 16 ATGTKTDTPIQKVPQSISVVTAEEMALHQPKSVKEALSYTPGVS----------VGTRGA 65 Query: 95 DSSYTLILVDG------KRVNSRNAVFRHNDFDLNWIPVDS--IERIEVVRGPMSSLYGS 146 ++Y +++ G + N N + +F N +D +ER E++RGP+S LYG Sbjct: 66 SNTYDHLIIRGFAAEGQSQNNYLNGLKLQGNF-YNDAVIDPYMLERAEIMRGPVSVLYGK 124 Query: 147 DALGGVVNIITKK 159 + GG++N+++K+ Sbjct: 125 SSPGGLLNMVSKR 137 Score = 32.3 bits (72), Expect = 0.64, Method: Compositional matrix adjust. Identities = 30/106 (28%), Positives = 46/106 (43%), Gaps = 8/106 (7%) Query: 516 PVFSYYNVN--KARIQGVETELKIPFNDEWKLSINYTYNDGR---DVSNGENKPLSDLPF 570 P S+++V + R +GVE E K + + +YTY D D + N P + +P Sbjct: 544 PEGSFFSVEGGEIRARGVEIEAKAALSASVNVVGSYTYTDAEYTTDTTYKGNTP-AQVPK 602 Query: 571 HTANGTLDWKPL--ALEDWSFYVSGHYTGQKRADSATAKTPGGYTI 614 H A+ D+ L + G YTG D A + G YT+ Sbjct: 603 HMASLWADYTFFDGPLSGLTLGTGGRYTGSSYGDPANSFKVGSYTV 648 >2W78-A nrPDB Length = 772 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 41/163 (25%), Positives = 79/163 (48%), Gaps = 11/163 (6%) Query: 34 VVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRG 93 + TA+ + ++ P SI+V+T++++ + N+ DV++ PG+ ++ +R RG Sbjct: 109 IATATRLVLTPRETPQSITVVTRQNMDDFGLNNIDDVMRHTPGITVSAYDTDRNNYYARG 168 Query: 94 LDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVV 153 S DG +RN + + L+ + + +R+EV++G L G+ +LG + Sbjct: 169 F--SINNFQYDGIPSTARNVGYSAGN-TLSDMAI--YDRVEVLKGATGLLTGAGSLGATI 223 Query: 154 NIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLID 196 N+I KK ++ G V + D Y + SGPL + Sbjct: 224 NLIRKKPTHEFKGHVELGA------GSWDNYRSELDVSGPLTE 260 >5FP1-A nrPDB Length = 718 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 44/134 (32%), Positives = 74/134 (55%), Gaps = 17/134 (12%) Query: 44 LKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQL-TNEGDNRKGVS--IRGLDSSYTL 100 L D P S+SVI+++ ++ V L D L+ VPG+ L EG N G IRG SS + Sbjct: 37 LLDTPKSVSVISKQLIEDTKVTTLADALRTVPGITLGAGEGGNPNGDRPFIRGY-SSESS 95 Query: 101 ILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITK-- 158 + +DG RN+ ++ + + ++E++EV +G S++ G+ ++GG +N+I+K Sbjct: 96 MYIDG----IRNSTSQNRE-------MFAVEQVEVTKGSASAMGGAGSVGGSINMISKVA 144 Query: 159 KIGQKWSGTVTVDT 172 K G G+V T Sbjct: 145 KKGDFLEGSVAAGT 158 Score = 48.5 bits (114), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 42/176 (23%), Positives = 72/176 (40%), Gaps = 18/176 (10%) Query: 506 FETGANGRRIPV--FSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGE-- 561 F T R+ + +Y NV ++++ G E L D+W +S YTY D NG+ Sbjct: 543 FRTEKQNTRVQIDPTTYANVGESKVDGFELGLNGEITDKWNISAGYTYLDSELTKNGKSC 602 Query: 562 -NKPLSDLPFHTANGTLDWKPLALEDWSFY---------VSGHYTGQKRADSATAKTPGG 611 + +D + N + A W+ Y Y+ + D A K Sbjct: 603 RSGKCTDQSIYNGNQMPNVPKQAATLWTTYKVLPQLTVGAGAVYSDKVYGDVANTKWVPS 662 Query: 612 YTIWNTGAAWQVTKDVKLRAGVLNLGDK----DLSRDDYSYNEDGRRYFMAVDYRF 663 Y ++ A + V K+V L+ + NL DK Y+ +GR +AV++++ Sbjct: 663 YVRYDAMARYNVNKNVDLQLNINNLSDKRYFTKAYASHYATEAEGRSAVLAVNFKY 718 >6FOK-A nrPDB Length = 723 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 160/723 (22%), Positives = 263/723 (36%), Gaps = 159/723 (21%) Query: 35 VTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGL 94 + S V + +P +I +E Q P + D LK +PG + G + +RG+ Sbjct: 66 LAPSVVTGVAQSSPLTIVTNPKEPRQPVPASDGADYLKTIPGFAVIRNGGSNGDPVLRGM 125 Query: 95 DSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVN 154 S IL +G + A D ++I ++ +++ V++GP + L+G A Sbjct: 126 FGSRLNILTNGGMM--LGACPNRMDAPTSYISPETYDKLTVIKGPQTVLWGPGAS----- 178 Query: 155 IITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFT-SGPLIDGVLGMKAYGSLA--KRE 211 +GT+ + + + G N S D VL A L + Sbjct: 179 ----------AGTILFEREPERFGELGSRVNASLLAGSNGRFDKVLDAAAGNRLGYLRFT 228 Query: 212 KDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNH--DFTAGYGFDRQDRDSDSLDK 269 + Q+ D + +G+V WTP+++ + TAG G +D Sbjct: 229 GNHAQSDDYEDGAGNTVPSRWKKWNGDVAVGWTPDEDTLIELTAGKGDGEARYAGRGMDG 288 Query: 270 NRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPITSES---NTVDGKYTLPLT 326 ++ +R++ + + S + EKVE + N + ++ T D +P+ Sbjct: 289 SQFKRESLGLR------FVKSNVSDVLEKVEAQVYYNYADHIMDNFRLRTPDPSSMMPMP 342 Query: 327 AINQF--LTVGGE----WRHD--KLSDAVNLTGG------------TSSKTSASQ----- 361 +Q T+GG WR D KL V+ T T A Q Sbjct: 343 MASQVDRRTLGGRLAATWRWDDFKLVTGVDAMRNEHRARGSKYDMMTDYYTDADQFPWSK 402 Query: 362 ------YALFVEDEWRIFEPLALTTGVRMDDHET-----------YGEHWS--------- 395 Y F E W E L G+R+D G + Sbjct: 403 DAVFHNYGAFGELTWFAAERDRLIGGLRLDRASVKDYRQTLKSGHMGHAMANPTANDTRA 462 Query: 396 ---PRAYLVYN---ATDTVTVKGGWATAFKAPSLLQL-SPDWTSNSCRGACKIVGSPD-L 447 P ++ Y A T+ G A + P +L SP RG V + D + Sbjct: 463 DTLPSGFVRYEHDLADSPTTLYAGLGHAERFPDYWELFSPK------RGPNGSVNAFDKI 516 Query: 448 KPETSESWELGLYYMGE--EGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVG 505 KPE + + GL Y G+ + W G + V+D I S + +G Sbjct: 517 KPEKTTQLDFGLQYNGDKLQAWASG-------YVGVVQDFILFSYR---------EGMMG 560 Query: 506 FETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKPL 565 T A NV+ ARI G E WK + Y G++ S +++ L Sbjct: 561 SSTQAT----------NVD-ARIMGGELGASYQLTGNWKTDASLAYAWGKNSS--DDRAL 607 Query: 566 SDLPFHTAN------------GTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTPGGYT 613 +P A G+L W+ +A ++ G+ G+ SA G+ Sbjct: 608 PQIPPLEARFGLTYEEGDWSAGSL-WRVVAPQNRIARDQGNVVGKDFDKSA------GFG 660 Query: 614 IWNTGAAWQVTKDVKLRAGVLNLGDKDLSRD---------DYSYN----EDGRRYFMAVD 660 +++ A++VT++VKL AGV NL DKD + +S N E GR ++ VD Sbjct: 661 VFSLNGAYRVTRNVKLSAGVDNLFDKDYTEHLNKAGDAGFGFSANETVPEPGRTFWTKVD 720 Query: 661 YRF 663 + F Sbjct: 721 FSF 723 >1KMO-A nrPDB Length = 774 Score = 55.5 bits (132), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 43/153 (28%), Positives = 74/153 (48%), Gaps = 12/153 (7%) Query: 22 PVLAVDDDGETMVV--TASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQL 79 P A +D T+V + E ++ + + VI +ED + +++VL +PGV Sbjct: 106 PAPAPKEDALTVVGDWLGDARENDVFEHAGARDVIRREDFAKTGATTMREVLNRIPGVSA 165 Query: 80 -----TNEGDNRKGVSIRGLD---SSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIE 131 T D IRGL+ +S + +L+DG V A + L + + +++ Sbjct: 166 PENNGTGSHDLAMNFGIRGLNPRLASRSTVLMDGIPVPF--APYGQPQLSLAPVSLGNMD 223 Query: 132 RIEVVRGPMSSLYGSDALGGVVNIITKKIGQKW 164 I+VVRG + YG ++GGVVN +T+ I Q + Sbjct: 224 AIDVVRGGGAVRYGPQSVGGVVNFVTRAIPQDF 256 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 75/351 (21%), Positives = 137/351 (39%), Gaps = 78/351 (22%) Query: 337 EWRHDKLSDAVNLTGGTS-----SKTSASQYALFVEDEWRIFEPLALTTGVRMDDHETY- 390 E R+ + + L G+S +++ +A +++D+ I +T G+R + E+Y Sbjct: 450 EMRYYTATSSGQLPSGSSPYDRDTRSGTEAHAWYLDDKIDIGN-WTITPGMRFEHIESYQ 508 Query: 391 -----GEHWS-------PRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGA 438 G H P ++Y+ TD+ + +F Q+ Sbjct: 509 NNAITGTHEEVSYNAPLPALNVLYHLTDSWNLYANTEGSFGTVQYSQIG----------- 557 Query: 439 CKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAP 498 K V S +++PE + +WELG Y ++G L + + +F + ++ ++T+D A Sbjct: 558 -KAVQSGNVEPEKARTWELGTRY--DDGAL---TAEMGLFLINFNNQYDSNQTNDTVTAR 611 Query: 499 GYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVS 558 G G ET A Y++ P D + +Y Y + Sbjct: 612 GKTRHTGLETQAR---------YDLGTL----------TPTLDNVSIYASYAYVNAEIRE 652 Query: 559 NGENK----PLSDLPFHTANGTLDWKPLALEDWSFYVSGHY----------TGQKRADSA 604 G+ P S P H +D+KP +W+F ++ + T ++ AD + Sbjct: 653 KGDTYGNLVPFS--PKHKGTLGVDYKP---GNWTFNLNSDFQSSQFADNANTVKESADGS 707 Query: 605 TAKTPGGYTIWNTGAAWQV---TKDVKLRAGVLNLGDKDLSRDDYSYNEDG 652 T + P G+ +W A+ D+ L GV N+ D+D Y N G Sbjct: 708 TGRIP-GFMLWGARVAYDFGPQMADLNLAFGVKNIFDQDYFIRSYDDNNKG 757 >6BPM-C nrPDB Length = 727 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 43/152 (28%), Positives = 73/152 (48%), Gaps = 35/152 (23%) Query: 44 LKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRK-----GVSIRGLDSSY 98 + D +++VI+++ ++ + NL D LK VPGV G+N + +RG D+S Sbjct: 35 VADTTRTMTVISEQVIKDQGATNLTDALKNVPGVGAFFAGENGNSTTGDAIYMRGADTSN 94 Query: 99 TLILVDGKRVNSRNAVFRHNDFDLNWIPVDSI--ERIEVVRGPMSSLYGSDALGGVVNII 156 + I +DG R D+ + D+ E++EV++GP + YG A G +N+I Sbjct: 95 S-IYIDGIR-------------DIGSVSRDTFNTEQVEVIKGPSGTDYGRSAPTGSINMI 140 Query: 157 TKK------------IGQKW--SGTVTVDTTI 174 +K+ IG W GT+ V+ I Sbjct: 141 SKQPRNDSGIDASASIGSAWFRRGTLDVNQVI 172 >5FOK-A nrPDB Length = 730 Score = 52.0 bits (123), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 45/150 (30%), Positives = 67/150 (44%), Gaps = 23/150 (15%) Query: 44 LKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQL-TNEGDNRKGVS--IRGLDSSYTL 100 L D P +++VI Q+ ++ L D L+ PG+ EG N G IRG ++ Sbjct: 46 LLDTPKTVTVIPQQVIKDTGALTLADALRTTPGITFGAGEGGNPAGDRPFIRGFNAESDT 105 Query: 101 ILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITKKI 160 L DG R D V ++E+IEV +GP S+ G+ + GG +N+I+K Sbjct: 106 FL-DGMR-----------DVASQTREVFNVEQIEVSKGPGSAYTGAGSTGGSLNLISKTA 153 Query: 161 GQ--------KWSGTVTVDTTIQEHRDRGD 182 Q W T TT+ +R GD Sbjct: 154 KQDNFTDAGFTWGSDQTRRTTLDVNRMIGD 183 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 72/339 (21%), Positives = 129/339 (38%), Gaps = 68/339 (20%) Query: 353 TSSKTSASQYALFVEDEWRIFEPLALTTGVRMDDHETYG--------------------- 391 T +KTSA+ +V D ++ E L G+R DD +T Sbjct: 421 TDTKTSAA----YVFDTLKLSEQWELNLGLRYDDFDTKSSGYQTAGRNGPAGYFKRENNS 476 Query: 392 EHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPET 451 W+ + LVY ++ W+T+ +P + A VG+ L PE Sbjct: 477 HFWNYQTGLVYKPAPNGSIYLAWSTS--------SNPTGETGGEGQADISVGNNGLDPER 528 Query: 452 SESWELGLYYMGEEGWLEGVESSVTVFRNDVKD-RISISRTSDVNAAPGYQNFVGFETGA 510 + + ELG + + + + + +FR D + R++ S + G Q Sbjct: 529 NRNLELGTKWAFFD---DALSLNAALFRTDKTNARVASPDVSTLQVLDGEQ--------- 576 Query: 511 NGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGR-DVSNGENKPLSDLP 569 R+QGVE ++WK+ YTY D S ++ + +P Sbjct: 577 ----------------RVQGVELGFNGKLTEKWKVFGGYTYLDSEIRKSTVKSDEGNKMP 620 Query: 570 FHTANGTLDWKPL-ALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVK 628 N W L++++ Y ++ ++A + Y ++ A+++V+K+V Sbjct: 621 QTAQNNFTLWTTYDLLQNFTIGGGTTYVDKQYGNTANSTYIPSYWRYDAMASYKVSKNVD 680 Query: 629 LRAGVLNLGDKDLSRDDYS----YNEDGRRYFMAVDYRF 663 L+ V NL DK YS + GR + V++ F Sbjct: 681 LQLNVQNLTDKRYFDQVYSTHMAHVAPGRTALLGVNFHF 719 >5NEC-A nrPDB Length = 741 Score = 51.2 bits (121), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 36/119 (30%), Positives = 61/119 (51%), Gaps = 15/119 (12%) Query: 44 LKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQL-TNEGDNRKGVS--IRGLDSSYTL 100 L D P S++V+ ++ ++ +L+D L+ VPG+ EG N G IRG D+ + Sbjct: 47 LLDTPRSVTVVPKQVIKDTAAVSLQDALRTVPGITFGAGEGGNPTGDRPFIRGFDAQ-SD 105 Query: 101 ILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITKK 159 VDG R D + ++E+IEV +GP S+ G + GG +N+++K+ Sbjct: 106 TYVDGVR-----------DTGAQTREIFNLEQIEVSKGPNSAFGGRGSAGGSLNLVSKQ 153 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 86/205 (41%), Gaps = 40/205 (19%) Query: 361 QYALFVEDEWRIFEPLALTTGVR----MDDHETYGEHWSPRAYLVYNATDTVTVKGGWAT 416 Q+ + + + FE A GVR + D ++ W+ +A LV+ ++ +AT Sbjct: 446 QWQVNIGARFDSFETTAKNHGVRPATKLSDKSSF---WNWQAGLVWKPVPNGSIYASYAT 502 Query: 417 AFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVT 476 + P + + D TSN+ G S +L+PE + ++ELG + + E +E S Sbjct: 503 SATPPGSMLDNGD-TSNAVDG---FAISNNLEPEETTNYELGTKWAF---FNERLELSAA 555 Query: 477 VFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELK 536 +FR D KD I V +T Y N ++R+ GVE Sbjct: 556 IFRTD-KDNTRI--------------LVANQT-----------YDNAGQSRVDGVELSAS 589 Query: 537 IPFNDEWKLSINYTYNDGRDVSNGE 561 ++WK+ Y+Y D V G+ Sbjct: 590 GKLTEKWKVFAGYSYLDSELVDAGK 614 >4RDT-A nrPDB Length = 748 Score = 46.2 bits (108), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 42/142 (29%), Positives = 67/142 (47%), Gaps = 14/142 (9%) Query: 29 DGETMVVTASSVEQN----LKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGD 84 D ET+ V S + L + AS +I+ + L++K V NL D L VPG+ + G Sbjct: 22 DLETVSVVGKSRPRATSGLLHTSTASDKIISGDTLRQKAV-NLGDALDGVPGIHASQYGG 80 Query: 85 NRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNW-IPVDSI--ERIEVVRGPMS 141 IRG +L N DF + I VD+ +++E++RGP++ Sbjct: 81 GASAPVIRGQTGRRIKVL------NHHGETGDMADFSPDHAIMVDTALSQQVEILRGPVT 134 Query: 142 SLYGSDALGGVVNIITKKIGQK 163 LY S + G+V++ KI +K Sbjct: 135 LLYSSGNVAGLVDVADGKIPEK 156 >3EFM-A nrPDB Length = 707 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 31/132 (23%), Positives = 64/132 (48%), Gaps = 6/132 (4%) Query: 36 TASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGLD 95 TA+ + + ++ P S+SV+T++ ++ + + + +L PG+ +T NR S RG Sbjct: 39 TATGLTLSPRETPQSVSVVTRQQIEDQGLTDTGAILATAPGISVTRSDSNRYSFSARGF- 97 Query: 96 SSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNI 155 + DG V+ + + + D++ D +E+VRG + GS VN Sbjct: 98 -TIDNFQFDGL-VSPILSQWNYGSTDMDAAIYD---HVEIVRGATGLMTGSGNPSAAVNF 152 Query: 156 ITKKIGQKWSGT 167 + K+ ++++ T Sbjct: 153 VRKRPLREFAAT 164 Score = 36.2 bits (82), Expect = 0.048, Method: Compositional matrix adjust. Identities = 51/228 (22%), Positives = 88/228 (38%), Gaps = 53/228 (23%) Query: 361 QYALFVEDEWRIFEPLALTTGVRMDDHET----YGE--------HWSPRAYLVYNATDTV 408 Q ++ + + EPL L G R D +T +G ++P A L Y+ DT Sbjct: 421 QTGAYLVGRFALAEPLHLIVGDRWSDWKTKQMYFGSRREYRIKNQFTPYAGLTYDINDTY 480 Query: 409 TVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWL 468 T + F+ P ++ G L P S+S+ELGL + +L Sbjct: 481 TAYASYTEIFQ--------PQNARDTSGGI--------LPPIKSKSYELGL----KAAYL 520 Query: 469 EG-VESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKAR 527 EG + +S +F+ + + S + PG+ N A+G A+ Sbjct: 521 EGRLNTSAALFQTRQDNLAQVIPGSSI---PGFPNMQA-SRAASG-------------AK 563 Query: 528 IQGVETELKIPFNDEWKLSINYTYNDGRDVSNGE---NKPLSDLPFHT 572 ++G++ E +W + +YT+ +D S N P S +T Sbjct: 564 VEGIDLEASGQILPDWNIGASYTHFTTKDASGNPINTNHPRSLFKLYT 611 >1XKW-A nrPDB Length = 665 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 38/173 (21%), Positives = 73/173 (42%), Gaps = 39/173 (22%) Query: 34 VVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRG 93 V T V ++ P S SVI E L+++ + +L + +++ GV+++ Sbjct: 11 VTTLGKVPLKPRELPQSASVIDHERLEQQNLFSLDEAMQQA------------TGVTVQP 58 Query: 94 LDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIP------------VDSIERIEVVRGPMS 141 T V G +V+S F+L+ +P + ER+E++RG Sbjct: 59 FQLLTTAYYVRGFKVDS---------FELDGVPALLGNTASSPQDMAIYERVEILRGSNG 109 Query: 142 SLYGSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPL 194 L+G+ VN++ K+ ++++ + T+ R D Y + GPL Sbjct: 110 LLHGTGNPAATVNLVRKRPQREFAASTTLSA------GRWDRYRAEVDVGGPL 156 >3V8X-A nrPDB Length = 904 Score = 42.4 bits (98), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 32/115 (27%), Positives = 57/115 (49%), Gaps = 9/115 (7%) Query: 53 VITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDN-RKGVSIRGLDSSYTLILVDG-KRVNS 110 V + + L ++ V N++D+ + PG+ + +G G SIRG+D + + VDG ++ S Sbjct: 51 VKSSDTLSKEQVLNIRDLTRYDPGIAVVEQGRGASSGYSIRGMDKNRVSLTVDGVSQIQS 110 Query: 111 RNAVF-------RHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITK 158 A + +N I ++++ +E+ +G S GS AL G V TK Sbjct: 111 YTAQAALGGTRTAGSSGAINEIEYENVKAVEISKGSNSVEQGSGALAGSVAFQTK 165 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 75/322 (23%), Positives = 108/322 (33%), Gaps = 63/322 (19%) Query: 353 TSSKTSASQYALFVEDEWRIFEPLALTTGVRMDDHETY--------GEH--WSPRAYLVY 402 T + Y V D R+ + G+R D T+ G H S A +V Sbjct: 562 TPRSINGKSYYAAVRDNVRLGRWADVGAGLRYDYRSTHSDDGSVSTGTHRTLSWNAGIVL 621 Query: 403 NATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYM 462 TD + + +T F+ PS ++ W + A KI PE S + E G+ + Sbjct: 622 KPTDWLDLTYRTSTGFRLPSFAEMY-GWRAGVQSKAVKI------DPEKSFNKEAGIVFK 674 Query: 463 GEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYN 522 G+ G LE + F N +D I R + G + G +Y N Sbjct: 675 GDFGNLE-----ASWFNNAYRDLIV--RGYEAQIKDGKEEAKGDP-----------AYLN 716 Query: 523 VNKARIQGVETELKIPFNDEW-KLS----INYTYNDGRDVSNGENKPLSDLPFHT----- 572 ARI G+ KI +N W KL + YN R + +D+ H Sbjct: 717 AQSARITGINILGKIDWNGVWDKLPEGWYSTFAYNRVRVRDIKKRADRTDIQSHLFDAIQ 776 Query: 573 ------------------ANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTPGGYTI 614 NG L + G R ATA+ + I Sbjct: 777 PSRYVVGLGYDQPEGKWGVNGMLTYSKAKEITELLGSRALLNGNSRNTKATARRTRPWYI 836 Query: 615 WNTGAAWQVTKDVKLRAGVLNL 636 + + V K LRAGV NL Sbjct: 837 VDVSGYYTVKKHFTLRAGVYNL 858 >6E4V-A nrPDB Length = 693 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/142 (22%), Positives = 62/142 (43%), Gaps = 23/142 (16%) Query: 28 DDGE-----TMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNE 82 DDGE T + ++ +D P S+++++Q+ ++ + +Q L +V++ G+ + Sbjct: 18 DDGENDYSVTSTSAGTKMQMTQRDIPQSVTIVSQQRMEDQQLQTLGEVMENTLGISKSQA 77 Query: 83 GDNRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSI------ERIEVV 136 +R RG +VDG F+ W D++ ER+EVV Sbjct: 78 DSDRALYYSRGFQIDN--YMVDGIPTY----------FESRWNLGDALSDMALFERVEVV 125 Query: 137 RGPMSSLYGSDALGGVVNIITK 158 RG + G+ +N++ K Sbjct: 126 RGATGLMTGTGNPSAAINMVRK 147 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 72/293 (24%), Positives = 115/293 (39%), Gaps = 59/293 (20%) Query: 363 ALFVEDEWRIFEPLALTTGVRMD----DHETYG---EHWSPRAYLVYNATDTVTVKGGWA 415 +L+ + +PL L G R D TY H +P A LV++ D W+ Sbjct: 418 SLYAATRVTLADPLHLILGARYTNWRVDTLTYSMEKNHTTPYAGLVFDINDN------WS 471 Query: 416 TAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWLEG-VESS 474 T S+ Q D S+ L P T ++ELGL + W+ + ++ Sbjct: 472 TYASYTSIFQPQNDRDSSGKY----------LAPITGNNYELGL----KSDWMNSRLTTT 517 Query: 475 VTVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETE 534 + +FR + +D ++ S + + G+NG +Y V+ +GVE E Sbjct: 518 LAIFRIE-QDNVAQSTGTPI-------------PGSNGET----AYKAVDGTVSKGVEFE 559 Query: 535 LKIPFNDEWKLSINYTYNDGRDVSNGENKPLSDLPFHTANGTLDWKPLALEDWSFYVSGH 594 L D W+L+ T D N N +LP T ++ + + + V G Sbjct: 560 LNGAITDNWQLTFGATRYIAED--NEGNAVNPNLPRTTVKMFTSYRLPVMPELT--VGGG 615 Query: 595 YTGQKRADSATAKTP--------GGYTIWNTGAAWQVTKDVKLRAGVLNLGDK 639 Q R + T TP G Y + + +QVTK+ L+ V NL DK Sbjct: 616 VNWQNRVYTDTV-TPYGTFRAEQGSYALVDLFTRYQVTKNFSLQGNVNNLFDK 667 >3CSL-A nrPDB Length = 865 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/161 (24%), Positives = 74/161 (45%), Gaps = 9/161 (5%) Query: 2 FRLNPFVRVGLC-LSAISCAWPVLAVDDDGETMVVTASSVEQN--LKDAPASISVITQED 58 FRL P ++ L L + LA+D V+ A N + D P S+SVI++E Sbjct: 74 FRLQPQGQIVLSRLPTANGDGGALALD---SLTVLGAGGNNANDWVYDEPRSVSVISREQ 130 Query: 59 LQRKPVQNLKDVLKEVPGV-QLTNEGDNRKGVSIRGL-DSSYTLILVDGKRVNSRNAVFR 116 + +P ++ D+L++ G ++ D V+IRG+ D + +DG R N + + Sbjct: 131 MDNRPARHAADILEQTTGAYSSVSQQDPALSVNIRGIQDYGRVNMNIDGMRQNFQKSGHG 190 Query: 117 HNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIIT 157 + + +I + + + + +G + + LGG+ T Sbjct: 191 QRNGTM-YIDSELLSGVTIDKGTTGGMGSAGTLGGIATFNT 230 Score = 34.7 bits (78), Expect = 0.14, Method: Compositional matrix adjust. Identities = 39/161 (24%), Positives = 63/161 (39%), Gaps = 38/161 (23%) Query: 376 LALTTGVR-MDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNS 434 +A+ GV ++ + TYG+ W P A T+T+T +++ + P+ Sbjct: 569 VAVRPGVEWLELYTTYGKSWRPPA-----ITETLTNGSAHSSSTQYPN------------ 611 Query: 435 CRGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDV 494 P L+PE S +WE+G + W EG V D K I+ D Sbjct: 612 ----------PFLQPERSRAWEVGFNVQQPDLWFEGDRLVAKVAYFDTKVDNYINLAIDR 661 Query: 495 NAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETEL 535 N Q +G N N++K R +G+E +L Sbjct: 662 NKPGLVQPSIGNAAYVN----------NLSKTRFRGLEYQL 692 >5FQ8-B nrPDB Length = 984 Score = 35.0 bits (79), Expect = 0.11, Method: Compositional matrix adjust. Identities = 42/150 (28%), Positives = 75/150 (50%), Gaps = 17/150 (11%) Query: 33 MVVTASSVEQNLKD-APASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDN---RKG 88 +VVTA ++++ K A+ SV ++ + + + + ++ GVQ+++ + Sbjct: 26 VVVTAMGIKRSEKALGYAATSVGGEKIAESRTSDVMSSLAGKIAGVQISSTSSDPGASNS 85 Query: 89 VSIRGLDS----SYTLILVDGKRVN-----SRNAVFRHNDFD--LNWIPVDSIERIEVVR 137 V IRG+ S + L +VDG +N S + + DF N I D + + +++ Sbjct: 86 VIIRGVSSLSGTNQPLYVVDGVPLNNSTVYSTDGLNSGYDFGNGANAINPDDVANMTILK 145 Query: 138 GPMS-SLYGSDALGGVVNIITKKIGQKWSG 166 G + +LYGS A GVV +IT K G+K G Sbjct: 146 GAAATALYGSRAANGVV-MITTKSGRKEKG 174 >4ZGV-A nrPDB Length = 868 Score = 30.8 bits (68), Expect = 1.9, Method: Compositional matrix adjust. Identities = 41/172 (23%), Positives = 70/172 (40%), Gaps = 35/172 (20%) Query: 31 ETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQN--LKDVLKEVPGVQLTNEGDNR-- 86 +T++V ++ Q++ + +I E +++ P N + ++LK P VQ +N + Sbjct: 54 DTILVRSTPTSQSM-----GMQIINAEQIKKMPTGNGSVTELLKNNPNVQFSNTASSSNI 108 Query: 87 ------KGVSIRGLDSSYTLILVDG-------------KRVNSRNAVFRHNDFDLN---- 123 + VS G +VDG +N + + D Sbjct: 109 PGELAPENVSFHGEKFYNNNFMVDGLSNNNNINPGANNGELNQQPDGYSPADLPAGGPQS 168 Query: 124 -WIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITKKIG-QKWSGTVTVDTT 173 WI + IE +EV +S+ YG D GGVV+ T K SG ++ TT Sbjct: 169 FWINSELIESLEVFDSNISAKYG-DFTGGVVDAKTMDPKLDKSSGKISYRTT 219 >6H7F-A nrPDB Length = 706 Score = 29.3 bits (64), Expect = 5.6, Method: Compositional matrix adjust. Identities = 13/30 (43%), Positives = 22/30 (73%), Gaps = 3/30 (10%) Query: 132 RIEVVRGPMSSLYG---SDALGGVVNIITK 158 R+EV++GP + L G + ++GG VN++TK Sbjct: 137 RVEVLKGPSALLNGMPPAGSVGGTVNLVTK 166 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2HDF-A nrPDB 827 0.0 5FP2-A nrPDB 558 e-159 5M9B-A nrPDB 557 e-159 1FEP-A nrPDB 537 e-153 5FR8-A nrPDB 536 e-153 6FOK-A nrPDB 425 e-119 1NQH-A nrPDB 413 e-115 3FHH-A nrPDB 401 e-112 5FP1-A nrPDB 203 2e-52 5FOK-A nrPDB 197 1e-50 4EPA-A nrPDB 195 6e-50 2W78-A nrPDB 184 1e-46 1KMO-A nrPDB 183 2e-46 1XKH-A nrPDB 181 9e-46 6E4V-A nrPDB 173 2e-43 1XKW-A nrPDB 166 2e-41 5NEC-A nrPDB 164 1e-40 3EFM-A nrPDB 163 3e-40 3QLB-A nrPDB 161 1e-39 6BPM-C nrPDB 146 2e-35 1FCP-A nrPDB 138 8e-33 4RDT-A nrPDB 130 2e-30 3V8X-A nrPDB 90 4e-18 Sequences not found previously or not previously below threshold: 3CSL-A nrPDB 121 1e-27 4AIP-A nrPDB 98 1e-20 4B7O-A nrPDB 94 2e-19 6H7F-A nrPDB 90 3e-18 5FQ8-B nrPDB 53 3e-07 5O9C-C nrPDB 36 0.059 4KQQ-A nrPDB 33 0.50 1OSM-A nrPDB 31 1.4 1QD5-A nrPDB 31 1.8 1GFN-A nrPDB 31 2.1 1QD6-C nrPDB 30 2.6 2EBS-A nrPDB 29 9.0 >2HDF-A nrPDB Length = 639 Score = 827 bits (2135), Expect = 0.0, Method: Composition-based stats. Identities = 634/639 (99%), Positives = 637/639 (99%) Query: 25 AVDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGD 84 +VDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGD Sbjct: 1 SVDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGD 60 Query: 85 NRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLY 144 NRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLY Sbjct: 61 NRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLY 120 Query: 145 GSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAY 204 GSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAY Sbjct: 121 GSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAY 180 Query: 205 GSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFDRQDRDS 264 GSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFDRQDRDS Sbjct: 181 GSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFDRQDRDS 240 Query: 265 DSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPITSESNTVDGKYTLP 324 DSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPITSESNTVDGKYTLP Sbjct: 241 DSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPITSESNTVDGKYTLP 300 Query: 325 LTAINQFLTVGGEWRHDKLSDAVNLTGGTSSKTSASQYALFVEDEWRIFEPLALTTGVRM 384 LTAINQFLTVGGE RHDK+SDAVNLTGGTSSKTSASQYALFVEDEWRIFEPLALTTGVRM Sbjct: 301 LTAINQFLTVGGEMRHDKMSDAVNLTGGTSSKTSASQYALFVEDEWRIFEPLALTTGVRM 360 Query: 385 DDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGS 444 DDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGS Sbjct: 361 DDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGS 420 Query: 445 PDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFV 504 PDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFV Sbjct: 421 PDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFV 480 Query: 505 GFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKP 564 GFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKP Sbjct: 481 GFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKP 540 Query: 565 LSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVT 624 LSDLPFHTANGTLDWKPLALEDWS Y+SGHYTGQKRADSATAKTPGGYTIWNTGAAWQVT Sbjct: 541 LSDLPFHTANGTLDWKPLALEDWSMYMSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVT 600 Query: 625 KDVKLRAGVLNLGDKDLSRDDYSYNEDGRRYFMAVDYRF 663 KDVKLRAGVLNLGDKDLSRDDYSYNEDGRRYFMAVDYRF Sbjct: 601 KDVKLRAGVLNLGDKDLSRDDYSYNEDGRRYFMAVDYRF 639 >5FP2-A nrPDB Length = 725 Score = 558 bits (1436), Expect = e-159, Method: Composition-based stats. Identities = 242/731 (33%), Positives = 352/731 (48%), Gaps = 118/731 (16%) Query: 23 VLAVDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKP-VQNLKDVLKEVPGVQLTN 81 +V G+ +V+ + EQ LK AP +S+IT ED++++P V +L ++++ +PGV LT Sbjct: 15 AESVVQLGDEVVL--GTAEQELKQAPG-VSIITAEDIRKRPPVNDLSEIIRTMPGVNLTG 71 Query: 82 EG-----DNRKGVSIRGLDSSYTLILVDGKRVNSRNAVF------RHNDFDLNWIPVDSI 130 N + + IRG+ TLILVDGK V+SRN+V R D NW+P + + Sbjct: 72 NSSSGQRGNNRQIDIRGMGPENTLILVDGKPVSSRNSVRYGWRGERDTRGDSNWVPPEEV 131 Query: 131 ERIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFT 190 ERIEV+RGP ++ YGS A GGVVNIITK+ + G++TV T I E G T F Sbjct: 132 ERIEVLRGPAAARYGSGAAGGVVNIITKRPTDRLRGSMTVFTNIPESSKDGATRRANFSL 191 Query: 191 SGPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGET---PRIEGFSSRDGNVEFAW--TP 245 SGPL + L +AYGS K + DD + + EG +RD + +W TP Sbjct: 192 SGPLTE-ALSFRAYGSANKTDSDDTDINLGHTVNPSRTVAGREGVRNRDLSGMLSWQVTP 250 Query: 246 NQNHDFTAG-------YGFDRQDRDS---------DSLDKNRLERQNYSVSHNGRWDYGT 289 +Q DF AG Y D Q+ + D + NR+ R+NY+++HNG W +GT Sbjct: 251 DQVVDFEAGFSRQGNIYAGDTQNNNGTANTQGLADDGAETNRMYRENYAITHNGTWSFGT 310 Query: 290 SELKYYGEK-------------VENKNPGNSSPITS--ESNTVDGKYTLPLTAI-NQFLT 333 S + VE + + S S E+ + G+ LPL A+ Q LT Sbjct: 311 SRFVAQYDSTRNNRLEEGLAGSVEGQIGADRSFSASKLENYRLSGELNLPLHALFEQVLT 370 Query: 334 VGGEWRHDKLSDAVNL---------------TGGTSSKTSASQYALFVEDEWRIFEPLAL 378 VG EW + L+D +L G S K+ A AL+VED + L Sbjct: 371 VGAEWNKETLNDPSSLKQGFVGSDSLPGTPAAGSRSPKSKAEIRALYVEDNIELRPGTML 430 Query: 379 TTGVRMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWT----SNS 434 T G+R+DDH +G +WSP + TVK G A AFKAP+L Q +P++ N Sbjct: 431 TPGLRLDDHSDFGLNWSPSLNASQTLGEYFTVKAGIARAFKAPNLYQSNPNYLLYTRGNG 490 Query: 435 C-----RGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISIS 489 C G C +VG+ +L ETS + ELG+ + +GW+ G +T FRND K++I Sbjct: 491 CPIQTSSGGCYLVGNENLDAETSVNKELGIEFR-RDGWVAG----LTYFRNDYKNKIVAP 545 Query: 490 RTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINY 549 G G + + N KA ++G+E L +P +++ S N Sbjct: 546 LDV---------------MGQTGTGNNILQWSNAKKAVVEGLEGNLLVPLHEDLSWSTNL 590 Query: 550 TYN-DGRDVSNGENKPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSATA-- 606 TY +D G PLS +P +T N TLDW+ A E S ++ G++ Sbjct: 591 TYMLQSKDKDTG--NPLSVIPEYTLNSTLDWQ--ASERLSTQLTSTIYGRQEPPKHGTSR 646 Query: 607 -------KTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRDDYS-------YNEDG 652 K G Y IW A + ++++ +R GV NL DK L R S YNE G Sbjct: 647 NTPVVSRKEVGTYGIWGVSAGYTFSENLSVRGGVSNLFDKRLYRQGNSFDAGAATYNEPG 706 Query: 653 RRYFMAVDYRF 663 R Y++++ F Sbjct: 707 RAYYVSMTTSF 717 >5M9B-A nrPDB Length = 724 Score = 557 bits (1435), Expect = e-159, Method: Composition-based stats. Identities = 233/737 (31%), Positives = 354/737 (48%), Gaps = 120/737 (16%) Query: 25 AVDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQN-LKDVLKEVPGVQLTNEG 83 +V + GE VV + ++ K AP +S+IT ED+ ++P N L +++ +PGV LT Sbjct: 10 SVIELGEQTVVA--TAQEETKQAPG-VSIITAEDIAKRPPSNDLSQIIRTMPGVNLTGNS 66 Query: 84 -----DNRKGVSIRGLDSSYTLILVDGKRVNSRNAVF------RHNDFDLNWIPVDSIER 132 N + + IRG+ TLILVDGK V+SRN+V R + D NW+P D +ER Sbjct: 67 SSGQRGNNRQIDIRGMGPENTLILVDGKPVSSRNSVRYGWRGERDSRGDTNWVPADQVER 126 Query: 133 IEVVRGPMSSLYGSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSG 192 IEV+RGP ++ YG+ A GGVVNIITK+ G + G ++V + +H+ G + F +G Sbjct: 127 IEVIRGPAAARYGNGAAGGVVNIITKQAGAETHGNLSVYSNFPQHKAEGASERMSFGLNG 186 Query: 193 PLIDGVLGMKAYGSLAKREKDD--------PQNSTTTDTGETPRIEGFSSRDGNVEFAW- 243 PL + L + YG++AK + DD + EG ++D + +W Sbjct: 187 PLTEN-LSYRVYGNIAKTDSDDWDINAGHESNRTGKQAGTLPAGREGVRNKDIDGLLSWR 245 Query: 244 -TPNQNHDFTAG-------YGFDRQDRDSDSL-------DKNRLERQNYSVSHNGRWDYG 288 TP Q +F AG Y D Q+ +S++ + NR+ R+ YSV+H G WD+G Sbjct: 246 LTPEQTLEFEAGFSRQGNIYTGDTQNTNSNNYVKQMLGHETNRMYRETYSVTHRGEWDFG 305 Query: 289 TSELKYYGEKVENK--------------NPGNSSPITSESN--TVDGKYTLPLT-AINQF 331 +S EK N +P N+ T+ T G+ LPL Q Sbjct: 306 SSLAYLQYEKTRNSRINEGLAGGTEGIFDPNNAGFYTATLRDLTAHGEVNLPLHLGYEQT 365 Query: 332 LTVGGEWRHDKLSDAVNLTGGTSSKTS--------------ASQYALFVEDEWRIFEPLA 377 LT+G EW KL D + T T S A ++LF ED + Sbjct: 366 LTLGSEWTEQKLDDPSSNTQNTEEGGSIPGLAGKNRSSSSSARIFSLFAEDNIELMPGTM 425 Query: 378 LTTGVRMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWT----SN 433 LT G+R D H+ G++WSP L + T+ VT+K G A A+KAP+L QL+PD+ Sbjct: 426 LTPGLRWDHHDIVGDNWSPSLNLSHALTERVTLKAGIARAYKAPNLYQLNPDYLLYSRGQ 485 Query: 434 SCRG---ACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISR 490 C G +C + G+ LK ETS + ELG+ Y +G+ + +T FRND K++I Sbjct: 486 GCYGQSTSCYLRGNDGLKAETSVNKELGIEYS-----HDGLVAGLTYFRNDYKNKIESGL 540 Query: 491 TSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYT 550 + +A+ G ++ ++ + NV KA ++G+E L +P D K S N T Sbjct: 541 SPVDHASGGKGDYANAA---------IYQWENVPKAVVEGLEGTLTLPLADGLKWSNNLT 591 Query: 551 YN-DGRDVSNGENKPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQ---KRADSATA 606 Y ++ G+ LS P +T N LDW+ A +D S + + G+ K+ D Sbjct: 592 YMLQSKNKETGD--VLSVTPRYTLNSMLDWQ--ATDDLSLQATVTWYGKQKPKKYDYHGD 647 Query: 607 KTPGG-------YTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRDDY------------- 646 + G Y I G ++++K++ L AGV NL DK L R Sbjct: 648 RVTGSANDQLSPYAIAGLGGTYRLSKNLSLGAGVDNLFDKRLFRAGNAQGVVGIDGAGAA 707 Query: 647 SYNEDGRRYFMAVDYRF 663 +YNE GR ++ ++ F Sbjct: 708 TYNEPGRTFYTSLTASF 724 >1FEP-A nrPDB Length = 724 Score = 537 bits (1384), Expect = e-153, Method: Composition-based stats. Identities = 233/751 (31%), Positives = 345/751 (45%), Gaps = 138/751 (18%) Query: 22 PVLAVDDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPV-QNLKDVLKEVPGVQLT 80 P +T+VVTA+ EQNL+ AP +S IT +++++ PV +++ +++ +PGV LT Sbjct: 3 PTDTPVSHDDTIVVTAA--EQNLQ-APG-VSTITADEIRKNPVARDVSKIIRTMPGVNLT 58 Query: 81 NEG-----DNRKGVSIRGLDSSYTLILVDGKRVNSRNAVF------RHNDFDLNWIPVDS 129 N + + IRG+ TLIL+DGK V+SRN+V R D +W+P + Sbjct: 59 GNSTSGQRGNNRQIDIRGMGPENTLILIDGKPVSSRNSVRQGWRGERDTRGDTSWVPPEM 118 Query: 130 IERIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFF 189 IERIEV+RGP ++ YG+ A GGVVNIITKK +W G+ EH++ G T F Sbjct: 119 IERIEVLRGPAAARYGNGAAGGVVNIITKKGSGEWHGSWDAYFNAPEHKEEGATKRTNFS 178 Query: 190 TSGPLIDGVLGMKAYGSLAKREKD--------DPQNSTTTDTGETPRIEGFSSRDGNVEF 241 +GPL D + YG+L K + D + T T EG ++D N Sbjct: 179 LTGPLGD-EFSFRLYGNLDKTQADAWDINQGHQSARAGTYATTLPAGREGVINKDINGVV 237 Query: 242 AW--TPNQNHDFTAGY-------GFDRQDRDSDSL-------DKNRLERQNYSVSHNGRW 285 W P Q+ + AGY D Q+ +SDS + NRL RQNY+++ NG W Sbjct: 238 RWDFAPLQSLELEAGYSRQGNLYAGDTQNTNSDSYTRSKYGDETNRLYRQNYALTWNGGW 297 Query: 286 DYG--TSELKYYGEKVENKNP----GNSSPITSESNTVD------------GKYTLPLTA 327 D G TS Y ++ P G + +E T D + LP+ Sbjct: 298 DNGVTTSNWVQYEHTRNSRIPEGLAGGTEGKFNEKATQDFVDIDLDDVMLHSEVNLPIDF 357 Query: 328 I-NQFLTVGGEWRHDKLSDAVNLTGG-----------------TSSKTSASQYALFVEDE 369 + NQ LT+G EW ++ D + T S + A ++LF E+ Sbjct: 358 LVNQTLTLGTEWNQQRMKDLSSNTQALTGTNTGGAIDGVSTTDRSPYSKAEIFSLFAENN 417 Query: 370 WRIFEPLALTTGVRMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPD 429 + + +T G+R D H G +WSP + D T+K G A A+KAPSL Q +P+ Sbjct: 418 MELTDSTIVTPGLRFDHHSIVGNNWSPALNISQGLGDDFTLKMGIARAYKAPSLYQTNPN 477 Query: 430 W----TSNSCR---GACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDV 482 + C G C + G+ DLK ETS + E+GL + +GWL GV T FRND Sbjct: 478 YILYSKGQGCYASAGGCYLQGNDDLKAETSINKEIGLEFK-RDGWLAGV----TWFRNDY 532 Query: 483 KDRISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDE 542 +++I G N ++ + NV KA ++G+E L +P ++ Sbjct: 533 RNKIEAGY---------------VAVGQNAVGTDLYQWDNVPKAVVEGLEGSLNVPVSET 577 Query: 543 WKLSINYTYN-DGRDVSNGENKPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRA 601 + N TY + + G+ LS +P +T N TL W+ A ED S + + G+++ Sbjct: 578 VMWTNNITYMLKSENKTTGD--RLSIIPEYTLNSTLSWQ--AREDLSMQTTFTWYGKQQP 633 Query: 602 DS----------ATAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSR-------- 643 K Y+I A W VTK+V L GV NL DK L R Sbjct: 634 KKYNYKGQPAVGPETKEISPYSIVGLSATWDVTKNVSLTGGVDNLFDKRLWRAGNAQTTG 693 Query: 644 -----------DDYSYNEDGRRYFMAVDYRF 663 Y+YNE GR ++M+V+ F Sbjct: 694 DLAGANYIAGAGAYTYNEPGRTWYMSVNTHF 724 >5FR8-A nrPDB Length = 733 Score = 536 bits (1381), Expect = e-153, Method: Composition-based stats. Identities = 232/734 (31%), Positives = 342/734 (46%), Gaps = 112/734 (15%) Query: 24 LAVDDDGETMVVTAS-SVEQNLKDAPASISVITQEDLQRKPVQN-LKDVLKEVPGVQLTN 81 A ET+ VTA V+Q+L +SVIT+EDL++ PV+N + D ++ +PGV LT Sbjct: 18 PAEPVKLETIFVTAEEQVKQSL-----GVSVITKEDLEKLPVRNDISDYVRRMPGVNLTG 72 Query: 82 EG-----DNRKGVSIRGLDSSYTLILVDGKRVNSRNAVF------RHNDFDLNWIPVDSI 130 N + + IRG+ TLILVDGK +NSRN+V R D NW+P ++I Sbjct: 73 NSATGQRGNNRQIDIRGMGPENTLILVDGKPINSRNSVRYGWKGERDTRGDSNWVPAEAI 132 Query: 131 ERIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFT 190 E IEV+RGP ++ YGS A GGVVNIITKK+ + G+V T+ E G + F Sbjct: 133 ESIEVLRGPAAARYGSGAAGGVVNIITKKVTNETHGSVEFYTSQPEDSKEGSSNRVGFNV 192 Query: 191 SGPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNH- 249 SGPLI VL + YG+ K E DD + + + EG ++D + AW Sbjct: 193 SGPLIKDVLSYRLYGNYNKTEADDVDINKSIGST-AAGREGVKNKDISGRLAWQATDQQT 251 Query: 250 ---DFTAG-----YGFDRQ---DRDSDSL-------DKNRLERQNYSVSHNGRWDYGTSE 291 D ++ Y D Q + ++D++ + N + R +Y+++H G W +G S+ Sbjct: 252 VLLDISSSKQGNIYSGDSQLNANAEADAILSQLIGKETNTMYRDSYALTHEGDWSWGKSK 311 Query: 292 LKYYGEKVENKN--PGNSSPITSESNTVDGKYTLPLTAIN--------------QFLTVG 335 L +K NK G + + + N +D K T L + Q LTVG Sbjct: 312 LVAQYDKTHNKRLPEGLAGSVEGKINNLDDKATSRLETLRFNGEANIPFEYYLPQVLTVG 371 Query: 336 GEWRHDKLSDAVN---------------LTGGTSSKTSASQYALFVEDEWRIFEPLALTT 380 EW D+ D V+ L G SK + + ++ED ++ + + Sbjct: 372 TEWVEDRFKDNVSTTQGKDSSGSGYGDQLAKGDRSKMESRIASAYIEDNLKVTDSTDVVL 431 Query: 381 GVRMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDW----TSNSC- 435 G+R DDH G +WSP + D T+KGG A A+KAP++ Q + + N C Sbjct: 432 GLRFDDHSKSGSNWSPSLNITQKLNDYFTLKGGVAKAYKAPNMYQNAEGYLLSTNGNGCP 491 Query: 436 ---RGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTS 492 C + G+ DLKPETS + ELG+ + + V +S+T FRND KD+I ++ T Sbjct: 492 ANIESRCLLQGNGDLKPETSVNKELGIQFQKDI-----VNASLTWFRNDYKDKI-VAGTH 545 Query: 493 DVNAAPGYQNFVGFETGA-NGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTY 551 V G + TGA + + + N KA IQG E L + F D + + N+TY Sbjct: 546 VVGTVDG--SSTNANTGAVTNTKWNILRWENTPKALIQGFEGSLGLDFGD-IRWTNNFTY 602 Query: 552 -NDGRDVSNGENKPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTPG 610 D +D G PLS +P +T N D+ D +F V Y QK A + Sbjct: 603 MMDSKDKQTG--NPLSLVPIYTINSIFDYDITDQLDVNF-VFTQYGRQKSRQFAENRLES 659 Query: 611 G-----------------YTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRDDYS----YN 649 G Y+ ++ + + R GV NL DK + RD S YN Sbjct: 660 GIGSGGANSALKPSTVKSYSTAGINVGYKFSDQISTRVGVSNLFDKQILRDSNSISQTYN 719 Query: 650 EDGRRYFMAVDYRF 663 E GR Y+ ++ Y F Sbjct: 720 EPGRAYYASLKYSF 733 >6FOK-A nrPDB Length = 723 Score = 425 bits (1093), Expect = e-119, Method: Composition-based stats. Identities = 155/720 (21%), Positives = 259/720 (35%), Gaps = 153/720 (21%) Query: 35 VTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGL 94 + S V + +P +I +E Q P + D LK +PG + G + +RG+ Sbjct: 66 LAPSVVTGVAQSSPLTIVTNPKEPRQPVPASDGADYLKTIPGFAVIRNGGSNGDPVLRGM 125 Query: 95 DSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVN 154 S IL +G + A D ++I ++ +++ V++GP + L+G A G Sbjct: 126 FGSRLNILTNGGMM--LGACPNRMDAPTSYISPETYDKLTVIKGPQTVLWGPGASAG--- 180 Query: 155 IITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFF-TSGPLIDGVLGMKAYGSLA--KRE 211 T+ + + + G N S D VL A L + Sbjct: 181 ------------TILFEREPERFGELGSRVNASLLAGSNGRFDKVLDAAAGNRLGYLRFT 228 Query: 212 KDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNH--DFTAGYGFDRQDRDSDSLDK 269 + Q+ D + +G+V WTP+++ + TAG G +D Sbjct: 229 GNHAQSDDYEDGAGNTVPSRWKKWNGDVAVGWTPDEDTLIELTAGKGDGEARYAGRGMDG 288 Query: 270 NRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPITSES---NTVDGKYTLPLT 326 ++ +R++ + + S + EKVE + N + ++ T D +P+ Sbjct: 289 SQFKRESLGLR------FVKSNVSDVLEKVEAQVYYNYADHIMDNFRLRTPDPSSMMPMP 342 Query: 327 AINQF--LTVGGE----WRHD--KLSDAVNLTGG------------TSSKTSASQ----- 361 +Q T+GG WR D KL V+ T T A Q Sbjct: 343 MASQVDRRTLGGRLAATWRWDDFKLVTGVDAMRNEHRARGSKYDMMTDYYTDADQFPWSK 402 Query: 362 ------YALFVEDEWRIFEPLALTTGVRMDDHET-----------YGEHWS--------- 395 Y F E W E L G+R+D G + Sbjct: 403 DAVFHNYGAFGELTWFAAERDRLIGGLRLDRASVKDYRQTLKSGHMGHAMANPTANDTRA 462 Query: 396 ---PRAYLVYN---ATDTVTVKGGWATAFKAPSLLQL-SPDWTSNSCRGACKIVGSPD-L 447 P ++ Y A T+ G A + P +L SP RG V + D + Sbjct: 463 DTLPSGFVRYEHDLADSPTTLYAGLGHAERFPDYWELFSPK------RGPNGSVNAFDKI 516 Query: 448 KPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVGFE 507 KPE + + GL Y G++ +++ + + V+D I S + +G Sbjct: 517 KPEKTTQLDFGLQYNGDK-----LQAWASGYVGVVQDFILFSYR---------EGMMGSS 562 Query: 508 TGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKPLSD 567 T A ARI G E WK + Y G++ S +++ L Sbjct: 563 TQATNV-----------DARIMGGELGASYQLTGNWKTDASLAYAWGKNSS--DDRALPQ 609 Query: 568 LPFHTANGTLD-----------WKPLALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWN 616 +P A L W+ +A ++ G+ G+ SA G+ +++ Sbjct: 610 IPPLEARFGLTYEEGDWSAGSLWRVVAPQNRIARDQGNVVGKDFDKSA------GFGVFS 663 Query: 617 TGAAWQVTKDVKLRAGVLNLGDKDLSRD---------DYSYN----EDGRRYFMAVDYRF 663 A++VT++VKL AGV NL DKD + +S N E GR ++ VD+ F Sbjct: 664 LNGAYRVTRNVKLSAGVDNLFDKDYTEHLNKAGDAGFGFSANETVPEPGRTFWTKVDFSF 723 >1NQH-A nrPDB Length = 594 Score = 413 bits (1061), Expect = e-115, Method: Composition-based stats. Identities = 172/674 (25%), Positives = 280/674 (41%), Gaps = 118/674 (17%) Query: 27 DDDGETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNR 86 D +T+VVTA+ EQ A +V+T++D+ R ++ DVL+ +PGV +T G + Sbjct: 2 DTSPDTLVVTANRFEQPRSTVLAPTTVVTRQDIDRWQSTSVNDVLRRLPGVDITQNGGSG 61 Query: 87 K--GVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLY 144 + + IRG ++S+ L+L+DG R+N DL+ P+ ++R+E +RGP S++Y Sbjct: 62 QLSSIFIRGTNASHVLVLIDGVRLNLAGV---SGSADLSQFPIALVQRVEYIRGPRSAVY 118 Query: 145 GSDALGGVVNIITKK------IGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGV 198 GSDA+GGVVNIIT + I W + + + GD G Sbjct: 119 GSDAIGGVVNIITTRDEPGTEISAGWGSNSYQNYDVSTQQQLGDKTRVTLLGDYAHTHG- 177 Query: 199 LGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFD 258 + AYG+ + + D + + + + N AW+ F GYG+D Sbjct: 178 YDVVAYGNTGTQAQTDNDGFLSKTL--------YGALEHNFTDAWS-----GFVRGYGYD 224 Query: 259 -RQDRD------SDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPIT 311 R + D S LD +L Q+ WD G L+Y GE ++++ + S Sbjct: 225 NRTNYDAYYSPGSPLLDTRKLYSQS--------WDAG---LRYNGELIKSQLITSYSHSK 273 Query: 312 SESNTVD-GKY--TLPLTAINQFLTVGGEWRHDKLSDAVNLTGGTS-SKTSASQYALFVE 367 + G+Y + L + Q+ +W ++ + ++ G K + + +VE Sbjct: 274 DYNYDPHYGRYDSSATLDEMKQYTV---QWANNVIVGHGSIGAGVDWQKQTTTPGTGYVE 330 Query: 368 DEWRIFEPLALTTGV------------RMDDHETYGEHWSPRAYLVYNATDTVTVKGGWA 415 D + TG+ R DD+ +G H + + + + + Sbjct: 331 DGYDQRNTGIYLTGLQQVGDFTFEGAARSDDNSQFGRHGTWQTSAGWEFIEGYRFIASYG 390 Query: 416 TAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSV 475 T++KAP+L QL G+P+L PE S+ WE EG GV + Sbjct: 391 TSYKAPNLGQLY------------GFYGNPNLDPEKSKQWEGAF-----EGLTAGVNWRI 433 Query: 476 TVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETEL 535 + +RNDV D I + YYN KARI+GVE Sbjct: 434 SGYRNDVSDLIDYDDHT-------------------------LKYYNEGKARIKGVEATA 468 Query: 536 KIPFNDEWKLSINYTYNDGRDVSNGENKPLSDLPFHTANGTLDWKPLALEDWSFYVSGHY 595 +++Y Y D R+ + PL LDW+ L D+ + ++ Y Sbjct: 469 NFD-TGPLTHTVSYDYVDARNAIT--DTPLLRRAKQQVKYQLDWQ---LYDFDWGITYQY 522 Query: 596 TGQKRADSATAKTP------GGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRDDYSYN 649 G R D + P GG ++W+ A+ VT + +R + NL DKD Y Y Sbjct: 523 LG-TRYDKDYSSYPYQTVKMGGVSLWDLAVAYPVTSHLTVRGKIANLFDKD-YETVYGYQ 580 Query: 650 EDGRRYFMAVDYRF 663 GR Y ++ Y F Sbjct: 581 TAGREYTLSGSYTF 594 >3FHH-A nrPDB Length = 640 Score = 401 bits (1030), Expect = e-112, Method: Composition-based stats. Identities = 165/690 (23%), Positives = 283/690 (41%), Gaps = 108/690 (15%) Query: 31 ETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEG-DNRKGV 89 ETM VTA+ ++ +AP +SVI + + + D+L+ VPG+ L G N + + Sbjct: 2 ETMTVTATGNARSSFEAPMMVSVIDTSAPENQTATSATDLLRHVPGITLDGTGRTNGQDI 61 Query: 90 SIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDAL 149 ++RG D L+LVDG R + D I+R+E+VRGP + LYGS AL Sbjct: 62 NMRGYDHRGVLVLVDGIRQGTDTGHLNGTFLD-----PALIKRVEIVRGPSALLYGSGAL 116 Query: 150 GGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGM--KAYGS- 206 GGV++ TV +QE + G + F +G D LG+ A+G Sbjct: 117 GGVISY----------DTVDAKDLLQEGQSSG----FRVFGTGGTGDHSLGLGASAFGRT 162 Query: 207 --------LAKREKDDPQNSTTTDT-----------GETPRIEGFSSRDGNVEF----AW 243 + R++ D + S T +I+ S G V + A Sbjct: 163 ENLDGIVAWSSRDRGDLRQSNGETAPNDESINNMLAKGTWQIDSAQSLSGLVRYYNNDAR 222 Query: 244 TPNQNHDFTAGYGFDRQDRDSDSLDKNRLERQ---NYSVSHNGR-WDYGTSELKYYGEKV 299 P A + + +D++ ++R +Y ++ G W +++ + ++ Sbjct: 223 EPKNPQTVEA------SESSNPMVDRSTIQRDAQLSYKLAPQGNDWLNADAKIYWSEVRI 276 Query: 300 ENKNPGNS----SPITSESNTVDGKYTLPLTAINQFLTVGGEW-RHDKLSDAVNLTGGTS 354 +N G+S IT + + + + LT GGE+ R ++ S + Sbjct: 277 NAQNTGSSGEYREQITKGARLENRSTLFADSFASHLLTYGGEYYRQEQGSHHHHHHHPGG 336 Query: 355 SKTSASQY-----ALFVEDEWRIFE-PLALTTGVRMDDH--------ETYGEHWSPRAYL 400 + T Q + +++DE + + P+ L G R D + + + WS RA + Sbjct: 337 ATTGFPQAKIDFSSGWLQDEITLRDLPITLLGGTRYDSYRGSSDGYKDVDADKWSSRAGM 396 Query: 401 VYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSC-RGACKI-VGSPDLKPETSESWELG 458 N T+ + + G +A AF+AP++ ++ D S R V +P+L+PET+E+ E G Sbjct: 397 TINPTNWLMLFGSYAQAFRAPTMGEMYNDSKHFSIGRFYTNYWVPNPNLRPETNETQEYG 456 Query: 459 LYYMGEEGWL--EGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIP 516 ++ L + +E + F KD IS T D AA Sbjct: 457 FGLRFDDLMLSNDALEFKASYFDTKAKDYIST--TVDFAAATTMS--------------- 499 Query: 517 VFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKPLSDLPFHTANGT 576 YNV A+I G + K D + L + Y G+D GE +S + T T Sbjct: 500 ----YNVPNAKIWGWDVMTKYT-TDLFSLDVAYNRTRGKDTDTGEY--ISSINPDTVTST 552 Query: 577 LDWKPLALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNL 636 L+ P+A +S G + + S++ GY + + ++Q + +K L L Sbjct: 553 LN-IPIAHSGFSVGWVGTFADRSTHISSSYSKQPGYGVNDFYVSYQGQQALKGMTTTLVL 611 Query: 637 ---GDKDLSRDDYSYNEDGRRYFMAVDYRF 663 DK+ +DGR + V Y++ Sbjct: 612 GNAFDKEYW-SPQGIPQDGRNGKIFVSYQW 640 >5FP1-A nrPDB Length = 718 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 130/740 (17%), Positives = 247/740 (33%), Gaps = 166/740 (22%) Query: 38 SSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQL-TNEGDNRKG--VSIRGL 94 S L D P S+SVI+++ ++ V L D L+ VPG+ L EG N G IRG Sbjct: 31 SKFVAPLLDTPKSVSVISKQLIEDTKVTTLADALRTVPGITLGAGEGGNPNGDRPFIRGY 90 Query: 95 DSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVR------GPMSSLYGS-- 146 SS + + +DG R ++ + ++E++EV + G S+ GS Sbjct: 91 -SSESSMYIDGIRNST-----------SQNREMFAVEQVEVTKGSASAMGGAGSVGGSIN 138 Query: 147 --------------DALGGVVNI--ITKKIGQKWSGTVTVDTTIQEHRDR--GDTYNGQF 188 G N IT + + + + H++ G + ++ Sbjct: 139 MISKVAKKGDFLEGSVAAGTDNYQRITLDGNKDFGNGIAARVAVLGHQNEKAGQSNGAEY 198 Query: 189 -------FTSGPLIDGVLGMKAYGSLAKREKDDP-----QNSTTTDTGETPRIE-----G 231 + L +Y L +K D +S G+ ++ G Sbjct: 199 KRVGIAPSITFGLDTPTRATLSYYYLQTDDKPDSGIPYWDSSLGKAQGKPAEVKQGTYYG 258 Query: 232 FSSRD--------GNVEFA-----------------------WTPNQNHDFTAGYGFDRQ 260 + RD G ++ WT + G G Sbjct: 259 WKDRDFQKQENHIGTIKLEHDLTDNITITNTAMYAKSKNDYVWTNPDDSKGNVGKGLVWH 318 Query: 261 DRDSDSLDKNRLERQNYSVSHNGRWDYG----TSELKYYGEKVENKNPGNSSPITSESNT 316 +S D Q ++ G++D G + K + G + + + Sbjct: 319 RLNSAITDSETFTDQ---LALTGKFDTGFLKHRFNVGAEYSKQKTDKGGYNIIDAKGNVS 375 Query: 317 VDGKYTLPLTAINQFLTVGGEWRHDKLSDAVNLTGGTSSKTSASQYALFVEDEWRIFEPL 376 G Y+ + T D + + ++ ++++ D I Sbjct: 376 STGFYSDCSDLSTNWCTSLNGPTQKPFVDRLQARPDFDATVEST--SVYLLDNIEITPKW 433 Query: 377 ALTTGVRMDDHETY-----------------GEHWSPRAYLVYNATDTVTVKGGWATAFK 419 L G+R D E + + +A + + T+ ++ +AT+ Sbjct: 434 LLDLGLRWDKFEAEQNFLATSSAAAYTAKNNSDFVTYQAGITFKPTENGSIYTSYATS-- 491 Query: 420 APSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFR 479 S + L+ W NS + + PE ++++E+G + + + + +FR Sbjct: 492 -ASPVGLNAGWGDNS---ETINANNQMIDPEEAQTFEIGTKWDFLD---NHLNLTAAIFR 544 Query: 480 NDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPF 539 + ++ +I +Y NV ++++ G E L Sbjct: 545 TEKQN--------------------------TRVQIDPTTYANVGESKVDGFELGLNGEI 578 Query: 540 NDEWKLSINYTYNDGRDVSNGEN---KPLSDLPFHTANGTLDWKPLALEDWSFY------ 590 D+W +S YTY D NG++ +D + N + A W+ Y Sbjct: 579 TDKWNISAGYTYLDSELTKNGKSCRSGKCTDQSIYNGNQMPNVPKQAATLWTTYKVLPQL 638 Query: 591 ---VSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDL----SR 643 Y+ + D A K Y ++ A + V K+V L+ + NL DK Sbjct: 639 TVGAGAVYSDKVYGDVANTKWVPSYVRYDAMARYNVNKNVDLQLNINNLSDKRYFTKAYA 698 Query: 644 DDYSYNEDGRRYFMAVDYRF 663 Y+ +GR +AV++++ Sbjct: 699 SHYATEAEGRSAVLAVNFKY 718 >5FOK-A nrPDB Length = 730 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 145/734 (19%), Positives = 244/734 (33%), Gaps = 158/734 (21%) Query: 36 TASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQL-TNEGDNRKG--VSIR 92 + L D P +++VI Q+ ++ L D L+ PG+ EG N G IR Sbjct: 38 ASKKYTAPLLDTPKTVTVIPQQVIKDTGALTLADALRTTPGITFGAGEGGNPAGDRPFIR 97 Query: 93 GLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGV 152 G ++ L DG R D V ++E+IEV +GP S+ G+ + GG Sbjct: 98 GFNAESDTFL-DGMR-----------DVASQTREVFNVEQIEVSKGPGSAYTGAGSTGGS 145 Query: 153 VNIITKKIGQK--------WSGTVTVDTTIQEHRDRGDTYNGQFF--------------- 189 +N+I+K Q W T TT+ +R GD + Sbjct: 146 LNLISKTAKQDNFTDAGFTWGSDQTRRTTLDVNRMIGDNAAFRLNLMKHDAHVAGRDEVS 205 Query: 190 ---------TSGPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVE 240 + +Y L+ + D T +S D + Sbjct: 206 VSRWGVAPTVTFGFDTPTRATLSYYHLSTDDMPDYGLPLTNVNRSKANPSKPASVDRDNF 265 Query: 241 FAWTPNQNHDFTAGYGFDRQDRD-SDSLD---KNRLERQNYS-VSHNGRWDYGTSELKYY 295 + T G R + D +D+L RL R + N G Y Sbjct: 266 YGLKDRDYRKSTTDSGTFRIEHDLNDNLTLSNSTRLVRTTLDYIVSNPDDSRGNVANGYV 325 Query: 296 GEKVENKNPGNSSPITSESNTVDGKYTLPLTAINQFLTVGGEWR-HDKLSDAVNLTGGTS 354 +++N + + N D K I L G E+ D + +T G Sbjct: 326 YRSAKSRNSTSKGWV----NQTDLKANFETGFIKHTLVTGLEFSYEDVHNRPYAITSGGG 381 Query: 355 SK-------------------------------------TSASQYALFVEDEWRIFEPLA 377 + T A +V D ++ E Sbjct: 382 AGNTCNARLLASGDCTSLNRPTPGDNWTGSITDGLAYTDTDTKTSAAYVFDTLKLSEQWE 441 Query: 378 LTTGVRMDD-------HETYGEH--------------WSPRAYLVYNATDTVTVKGGWAT 416 L G+R DD ++T G + W+ + LVY ++ W+T Sbjct: 442 LNLGLRYDDFDTKSSGYQTAGRNGPAGYFKRENNSHFWNYQTGLVYKPAPNGSIYLAWST 501 Query: 417 AFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVT 476 + +P + A VG+ L PE + + ELG + + + + + Sbjct: 502 S--------SNPTGETGGEGQADISVGNNGLDPERNRNLELGTKWAFFD---DALSLNAA 550 Query: 477 VFRNDVKD-RISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETEL 535 +FR D + R++ S + G Q R+QGVE Sbjct: 551 LFRTDKTNARVASPDVSTLQVLDGEQ-------------------------RVQGVELGF 585 Query: 536 KIPFNDEWKLSINYTYNDGRDVSNGENKPLSDLPFHTA--NGTLDWKPLALEDWSFYVSG 593 ++WK+ YTY D + + TA N TL L++++ Sbjct: 586 NGKLTEKWKVFGGYTYLDSEIRKSTVKSDEGNKMPQTAQNNFTLWTTYDLLQNFTIGGGT 645 Query: 594 HYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRDDYSYN---- 649 Y ++ ++A + Y ++ A+++V+K+V L+ V NL DK YS + Sbjct: 646 TYVDKQYGNTANSTYIPSYWRYDAMASYKVSKNVDLQLNVQNLTDKRYFDQVYSTHMAHV 705 Query: 650 EDGRRYFMAVDYRF 663 GR + V++ F Sbjct: 706 APGRTALLGVNFHF 719 >4EPA-A nrPDB Length = 655 Score = 195 bits (494), Expect = 6e-50, Method: Composition-based stats. Identities = 129/673 (19%), Positives = 231/673 (34%), Gaps = 105/673 (15%) Query: 28 DDGETMVVTASSVEQNLKDAPA---SISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGD 84 D T+VVTAS Q+ + A A S +V++ +L V + + +PG+ + N G+ Sbjct: 9 QDESTLVVTASK--QSSRSASANNVSSTVVSAPELSDAGVTASDKLPRVLPGLNIENSGN 66 Query: 85 NR-KGVSIRGLDSSYTLI------LVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVR 137 +S+RG+ S+ VDG S N + D ++ +E++R Sbjct: 67 MLFSTISLRGVSSAQDFYNPAVTLYVDGVPQLSTNTIQALTD----------VQSVELLR 116 Query: 138 GPMSSLYGSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDG 197 GP +LYG A GG++NI+T++ G + + D+Y +F SGP+ DG Sbjct: 117 GPQGTLYGKSAQGGIINIVTQQPDSTPRGYI------EGGVSSRDSYRSKFNLSGPIQDG 170 Query: 198 VLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQN---HDFTAG 254 +L YGS+ + D + TG + + G + GNV+ P+ F A Sbjct: 171 LL----YGSVTLLRQVDDGDMINPATG-SDDLGGTRASIGNVKLRLAPDDQPWEMGFAAS 225 Query: 255 YGFDRQDRD---------------SDSLDKNRLERQNYSVSHNGRW---DYGTSELKYYG 296 R +D SD + R S + +G++ D+ + + + Sbjct: 226 RECTRATQDAYVGWNDIKGRKLSISDGSPDPYMRRCTDSQTLSGKYTTDDWVFNLISAWQ 285 Query: 297 EKVENKNPGNSSPITSESNTVDGKY----TLPLTAINQFLTVGGEWRHDKLSDAVNLTG- 351 ++ ++ + S I + + L V G +R + + Sbjct: 286 QQHYSRTFPSGSLIVNMPQRWNQDVQELRAATLGDARTVDMVFGLYRQNTREKLNSAYDM 345 Query: 352 ------GTSSKTSASQYALFVEDEWRIFEPLALTTGVRMDD---HETYGEHWSPRAYLVY 402 ++ T+A A + + W + + + GVR Y + Sbjct: 346 PTMPYLSSTGYTTAETLAAYSDLTWHLTDRFDIGGGVRFSHDKSSTQYHGSMLGNPFGDQ 405 Query: 403 NATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLK-----PETSESWEL 457 ++ V G + + ++ IV + L E S ++EL Sbjct: 406 GKSNDDQVLGQLSAGYMLTDDWRVYTRVAQGYKPSGYNIVPTAGLDAKPFVAEKSINYEL 465 Query: 458 GLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIPV 517 G Y + V F KD S + + Sbjct: 466 GTRYETAD-----VTLQAATFYTHTKDMQLYSG-----------------------PVRM 497 Query: 518 FSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGE---NKPLSDLPFHTAN 574 + N KA GVE E K F W IN ++ E + +P + A Sbjct: 498 QTLSNAGKADATGVELEAKWRFAPGWSWDINGNVIRSEFTNDSELYHGNRVPFVPRYGAG 557 Query: 575 GTLDWKPLALEDWSF-YVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLRAGV 633 +++ ++ + G D G Y ++ WQ T+ + + V Sbjct: 558 SSVNGVIDTRYGALMPRLAVNLVGPHYFDGDNQLRQGTYATLDSSLGWQATERMNISVYV 617 Query: 634 LNLGDKDLSRDDY 646 NL D+ Y Sbjct: 618 DNLFDRRYRTYGY 630 >2W78-A nrPDB Length = 772 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 112/687 (16%), Positives = 223/687 (32%), Gaps = 124/687 (18%) Query: 33 MVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIR 92 + TA+ + ++ P SI+V+T++++ + N+ DV++ PG+ ++ +R R Sbjct: 108 TIATATRLVLTPRETPQSITVVTRQNMDDFGLNNIDDVMRHTPGITVSAYDTDRNNYYAR 167 Query: 93 GLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGV 152 G S DG +RN + + + + +R+EV++G L G+ +LG Sbjct: 168 GF--SINNFQYDGIPSTARNVGYSAGNTLSD---MAIYDRVEVLKGATGLLTGAGSLGAT 222 Query: 153 VNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLI--------------DGV 198 +N+I KK ++ G V + D Y + SGPL D Sbjct: 223 INLIRKKPTHEFKGHVELGA------GSWDNYRSELDVSGPLTESGNVRGRAVAAYQDKH 276 Query: 199 LGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFD 258 M Y + DT T + + D W+ + + G D Sbjct: 277 SFMDHYERKTSVYYGILEFDLNPDTMLTVGAD-YQDNDPKGS-GWSGSFPLFDSQGNRND 334 Query: 259 RQDRDSDSLDKNRLERQNYSVSHNGRWDYGTSEL--KYYGEKVEN------------KNP 304 ++ + E+ +V N ++ + K+ P Sbjct: 335 VSRSFNNGAKWSSWEQYTRTVFANLEHNFANGWVGKVQLDHKINGYHAPLGAIMGDWPAP 394 Query: 305 GNSSPITSESNTVDGKYT---------LPLTAINQFLTVGGE-----------WR----- 339 NS+ I ++ T + K L VG W Sbjct: 395 DNSAKIVAQKYTGETKSNSLDIYLTGPFQFLGREHELVVGTSASFSHWEGKSYWNLRNYD 454 Query: 340 ---HDKLSDAVNLTGGTSSK------TSASQYALFVEDEWRIFEPLALTTGVRMDDHETY 390 D ++ ++ Q ++ + + + L L G R+ D+ Sbjct: 455 NTTDDFINWDGDIGKPDWGTPSQYIDDKTRQLGSYMTARFNVTDDLNLFLGGRVVDYRVT 514 Query: 391 GEHWS--------PRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIV 442 G + + P VY+ DT +V + F + Sbjct: 515 GLNPTIRESGRFIPYVGAVYDLNDTYSVYASYTDIFMPQDSW--------------YRDS 560 Query: 443 GSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQN 502 + L+P+ +++E+G+ +G L +S+ F ++R Sbjct: 561 SNKLLEPDEGQNYEIGIKGEYLDGRL---NTSLAYFEIHEENRAEED------------- 604 Query: 503 FVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGEN 562 + + Y KA+ +G E E+ W++ YT+ RD S + Sbjct: 605 ---ALYNSKPTNPAITYAYKGIKAKTKGYEAEISGELAPGWQVQAGYTHKIIRDDSGKKV 661 Query: 563 KPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKR---ADSATAKT----PGGYTIW 615 + + +K AL+ + + G+ ++ ++ Y + Sbjct: 662 STWEPQDQLSLYTSYKFKG-ALDKLTVGGGARWQGKSWQMVYNNPRSRWEKFSQEDYWLV 720 Query: 616 NTGAAWQVTKDVKLRAGVLNLGDKDLS 642 + A +Q+T + V N+ DK Sbjct: 721 DLMARYQITDKLSASVNVNNVFDKTYY 747 >1KMO-A nrPDB Length = 774 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 131/726 (18%), Positives = 249/726 (34%), Gaps = 141/726 (19%) Query: 22 PVLAVDDDGETMVV--TASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQL 79 P A +D T+V + E ++ + + VI +ED + +++VL +PGV Sbjct: 106 PAPAPKEDALTVVGDWLGDARENDVFEHAGARDVIRREDFAKTGATTMREVLNRIPGVSA 165 Query: 80 -----TNEGDNRKGVSIRGLDS---SYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIE 131 T D IRGL+ S + +L+DG V A + L + + +++ Sbjct: 166 PENNGTGSHDLAMNFGIRGLNPRLASRSTVLMDGIPVPF--APYGQPQLSLAPVSLGNMD 223 Query: 132 RIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTS 191 I+VVRG + YG ++GGVVN +T+ I Q + V+ + + + Sbjct: 224 AIDVVRGGGAVRYGPQSVGGVVNFVTRAIPQDFGIEAGVEGQLSPTSSQNNPKETHNLMV 283 Query: 192 GPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEF--AWTPNQNH 249 G D G + T + E ++R ++ + P++ H Sbjct: 284 GGTADNGFGTAL---------------LYSGTRGSDWREHSATRIDDLMLKSKYAPDEVH 328 Query: 250 DFTAGYGFDRQDRDSD-SLDKNRLERQNYSVSHNGRWDYGTSELK--------YYGEKVE 300 F + + + D L + + + + +G +L K Sbjct: 329 TFNSLLQYYDGEADMPGGLSRADYDADRWQSTRPYDRFWGRRKLASLGYQFQPDSQHKFN 388 Query: 301 NKNPGNSSPITSESNTVDGKYTLP--------LTAINQFLTVGG---------------- 336 + + + P +Q +G Sbjct: 389 IQGFYTQTLRSGYLEQGKRITLSPRNYWVRGIEPRYSQIFMIGPSAHEVGVGYRYLNEST 448 Query: 337 -EWRHDKLSDAVNLTGGTSSK-----TSASQYALFVEDEWRIFEPLALTTGVRMDDHETY 390 E R+ + + L G+S + +A +++D+ I T G+R + E+Y Sbjct: 449 HEMRYYTATSSGQLPSGSSPYDRDTRSGTEAHAWYLDDKIDIGNWTI-TPGMRFEHIESY 507 Query: 391 GEHWS-------------PRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRG 437 + P ++Y+ TD+ + +F Q+ Sbjct: 508 QNNAITGTHEEVSYNAPLPALNVLYHLTDSWNLYANTEGSFGTVQYSQIG---------- 557 Query: 438 ACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAA 497 K V S +++PE + +WELG Y ++G + + + +F + ++ ++T+D A Sbjct: 558 --KAVQSGNVEPEKARTWELGTRY--DDG---ALTAEMGLFLINFNNQYDSNQTNDTVTA 610 Query: 498 PGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDV 557 G G ET A + P D + +Y Y + Sbjct: 611 RGKTRHTGLETQAR-------------------YDLGTLTPTLDNVSIYASYAYVNAEIR 651 Query: 558 SNGEN--KPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTP------ 609 G+ + P H +D+KP +W+F ++ + + AD+A Sbjct: 652 EKGDTYGNLVPFSPKHKGTLGVDYKPG---NWTFNLNSDFQSSQFADNANTVKESADGST 708 Query: 610 ---GGYTIWNTGAAWQV---TKDVKLRAGVLNLGDKDLSRDDYSYNEDG------RRYFM 657 G+ +W A+ D+ L GV N+ D+D Y N G R +M Sbjct: 709 GRIPGFMLWGARVAYDFGPQMADLNLAFGVKNIFDQDYFIRSYDDNNKGIYAGQPRTLYM 768 Query: 658 AVDYRF 663 +F Sbjct: 769 QGSLKF 774 >1XKH-A nrPDB Length = 687 Score = 181 bits (458), Expect = 9e-46, Method: Composition-based stats. Identities = 112/687 (16%), Positives = 223/687 (32%), Gaps = 124/687 (18%) Query: 33 MVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIR 92 + TA+ + ++ P SI+V+T++++ + N+ DV++ PG+ ++ +R R Sbjct: 23 TIATATRLVLTPRETPQSITVVTRQNMDDFGLNNIDDVMRHTPGITVSAYDTDRNNYYAR 82 Query: 93 GLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGV 152 G S DG +RN + + + + +R+EV++G L G+ +LG Sbjct: 83 GF--SINNFQYDGIPSTARNVGYSAGNTLSD---MAIYDRVEVLKGATGLLTGAGSLGAT 137 Query: 153 VNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLI--------------DGV 198 +N+I KK ++ G V + D Y + SGPL D Sbjct: 138 INLIRKKPTHEFKGHVELGA------GSWDNYRSELDVSGPLTESGNVRGRAVAAYQDKH 191 Query: 199 LGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFD 258 M Y + DT T + + D W+ + + G D Sbjct: 192 SFMDHYERKTSVYYGILEFDLNPDTMLTVGAD-YQDNDPKGS-GWSGSFPLFDSQGNRND 249 Query: 259 RQDRDSDSLDKNRLERQNYSVSHNGRWDYGTSEL--KYYGEKVEN------------KNP 304 ++ + E+ +V N ++ + K+ P Sbjct: 250 VSRSFNNGAKWSSWEQYTRTVFANLEHNFANGWVGKVQLDHKINGYHAPLGAIMGDWPAP 309 Query: 305 GNSSPITSESNTVDGKYT---------LPLTAINQFLTVGGE-----------WR----- 339 NS+ I ++ T + K L VG W Sbjct: 310 DNSAKIVAQKYTGETKSNSLDIYLTGPFQFLGREHELVVGTSASFSHWEGKSYWNLRNYD 369 Query: 340 ---HDKLSDAVNLTGGTSSK------TSASQYALFVEDEWRIFEPLALTTGVRMDDHETY 390 D ++ ++ Q ++ + + + L L G R+ D+ Sbjct: 370 NTTDDFINWDGDIGKPDWGTPSQYIDDKTRQLGSYMTARFNVTDDLNLFLGGRVVDYRVT 429 Query: 391 GEHWS--------PRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIV 442 G + + P VY+ DT +V + F + Sbjct: 430 GLNPTIRESGRFIPYVGAVYDLNDTYSVYASYTDIFMPQDSW--------------YRDS 475 Query: 443 GSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQN 502 + L+P+ +++E+G+ +G L +S+ F ++R Sbjct: 476 SNKLLEPDEGQNYEIGIKGEYLDGRL---NTSLAYFEIHEENRAEED------------- 519 Query: 503 FVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGEN 562 + + Y KA+ +G E E+ W++ YT+ RD S + Sbjct: 520 ---ALYNSKPTNPAITYAYKGIKAKTKGYEAEISGELAPGWQVQAGYTHKIIRDDSGKKV 576 Query: 563 KPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKR---ADSATAKT----PGGYTIW 615 + + +K AL+ + + G+ ++ ++ Y + Sbjct: 577 STWEPQDQLSLYTSYKFKG-ALDKLTVGGGARWQGKSWQMVYNNPRSRWEKFSQEDYWLV 635 Query: 616 NTGAAWQVTKDVKLRAGVLNLGDKDLS 642 + A +Q+T + V N+ DK Sbjct: 636 DLMARYQITDKLSASVNVNNVFDKTYY 662 >6E4V-A nrPDB Length = 693 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 120/729 (16%), Positives = 229/729 (31%), Gaps = 146/729 (20%) Query: 28 DDGE-----TMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNE 82 DDGE T + ++ +D P S+++++Q+ ++ + +Q L +V++ G+ + Sbjct: 18 DDGENDYSVTSTSAGTKMQMTQRDIPQSVTIVSQQRMEDQQLQTLGEVMENTLGISKSQA 77 Query: 83 GDNRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSS 142 +R RG +VDG + + D + + ER+EVVRG Sbjct: 78 DSDRALYYSRGFQ--IDNYMVDGIPTYFE-SRWNLGDALSD---MALFERVEVVRGATGL 131 Query: 143 LYGSDALGGVVNIITKKIG-QKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLI-DGVLG 200 + G+ +N++ K +++ G V+ + + PL DG + Sbjct: 132 MTGTGNPSAAINMVRKHATSREFKGDVSAEY------GSWNKERYVADLQSPLTEDGKIR 185 Query: 201 MKA-------------YGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQ 247 + Y S T + E + + P Sbjct: 186 ARIVGGYQNNDSWLDRYNSEKTFFSGIVDADLGDLTTLSAGYEYQRIDVNSPTWGGLPRW 245 Query: 248 NHDFTAGYGFDRQDRDSDSLDKNRLE--------RQNYSVSHNGRWDYG------TSELK 293 N D + +DR + N E +Q ++ + + S++ Sbjct: 246 NTD-GSSNSYDRARSTAPDWAYNDKEINKVFMTLKQQFADTWQATLNATHSEVEFDSKMM 304 Query: 294 YYGEKVENKNPGNSSPIT---------------SESNTVDGKYTLPLTAIN-----QFLT 333 Y V + P + S VD + L Sbjct: 305 YVDAYVNKADGMLVGPYSNYGPGFDYVGGTGWNSGKRKVDALDLFADGSYELFGRQHNLM 364 Query: 334 VGGEWRH--------------DKLSDAVNLTGGTSSKTSASQY----------ALFVEDE 369 GG + D++ N G + Q +L+ Sbjct: 365 FGGSYSKQNNRYFSSWANIFPDEIGSFYNFNGNFPQTDWSPQSLAQDDTTHMKSLYAATR 424 Query: 370 WRIFEPLALTTGVRMDD-------HETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPS 422 + +PL L G R + + H +P A LV++ D + + + F+ + Sbjct: 425 VTLADPLHLILGARYTNWRVDTLTYSMEKNHTTPYAGLVFDINDNWSTYASYTSIFQPQN 484 Query: 423 LLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDV 482 S + L P T ++ELGL + + +++ +FR + Sbjct: 485 DRDSSGKY----------------LAPITGNNYELGL---KSDWMNSRLTTTLAIFRIEQ 525 Query: 483 KDRISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDE 542 + + T + +Y V+ +GVE EL D Sbjct: 526 DNVAQSTGTPIPGSNGE------------------TAYKAVDGTVSKGVEFELNGAITDN 567 Query: 543 WKLSINYTYNDGRDVSNGENKPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRAD 602 W+L+ T D P +LP T ++ + + + ++ + D Sbjct: 568 WQLTFGATRYIAEDNEGNAVNP--NLPRTTVKMFTSYRLPVMPELTVGGGVNWQNRVYTD 625 Query: 603 SAT-----AKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDL---SRDDYSYNEDGRR 654 + T G Y + + +QVTK+ L+ V NL DK Y R Sbjct: 626 TVTPYGTFRAEQGSYALVDLFTRYQVTKNFSLQGNVNNLFDKTYDTNVEGSIVYGTP-RN 684 Query: 655 YFMAVDYRF 663 + + Y+F Sbjct: 685 FSITGTYQF 693 >1XKW-A nrPDB Length = 665 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 124/720 (17%), Positives = 220/720 (30%), Gaps = 155/720 (21%) Query: 34 VVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRG 93 V T V ++ P S SVI E L+++ + +L + +++ GV + +RG Sbjct: 11 VTTLGKVPLKPRELPQSASVIDHERLEQQNLFSLDEAMQQATGVTVQPFQLLTTAYYVRG 70 Query: 94 LDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVV 153 +DG + + + ER+E++RG L+G+ V Sbjct: 71 FKV--DSFELDGVP-------ALLGNTASSPQDMAIYERVEILRGSNGLLHGTGNPAATV 121 Query: 154 NIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAYGSL-AKREK 212 N++ K+ ++++ + T+ R D Y + GPL A G++ + Sbjct: 122 NLVRKRPQREFAASTTLSA------GRWDRYRAEVDVGGPL-------SASGNVRGRAVA 168 Query: 213 DDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGFDRQDRDSDSL----- 267 D + +G G EF +P+ A Y + + Sbjct: 169 AYEDRDYFYDVAD----QGTRLLYGVTEFDLSPDTLLTVGAQYQHIDSITNMAGVPMAKD 224 Query: 268 --------------DKNRLERQNYSV------SHNGRWDYGTSELKYYGEKVENKNPGNS 307 D +R + Y G W G +Y + G+ Sbjct: 225 GSNLGLSRDTYLDVDWDRFKWDTYRAFGSLEQQLGGGWK-GKVSAEYQEADSRLRYAGSF 283 Query: 308 SPI-----------------TSESNTVDGKYTLPL-------TAINQFLTVGGEWRHDKL 343 I S ++D P+ + GE R D Sbjct: 284 GAIDPQTGDGGQLMGAAYKFKSIQRSLDANLNGPVRLFGLTHELLGGVTYAQGETRQDTA 343 Query: 344 S--------------DAVNLTGG-TSSKTS-----ASQYALFVEDEWRIFEPLALTTGVR 383 D + TS +Q L+ ++ EPL L G R Sbjct: 344 RFLNLPNTPVNVYRWDPHGVPRPQIGQYTSPGTTTTTQKGLYALGRIKLAEPLTLVVGGR 403 Query: 384 MDDHETY--------GEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSC 435 + G ++P L+++ + +A ++ + Q Sbjct: 404 ESWWDQDTPATRFKPGRQFTPYGGLIWDFARDWSWYVSYAEVYQPQADRQTW-------- 455 Query: 436 RGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVN 495 S L P +++E G+ +G L S+ FR D+++ + Sbjct: 456 -------NSEPLSPVEGKTYETGIKGELADGRL---NLSLAAFRIDLEN-----NPQEDP 500 Query: 496 AAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGR 555 PG N + +G K R QG E E W LS YTY Sbjct: 501 DHPGPPNNPFYISG--------------GKVRSQGFELEGTGYLTPYWSLSAGYTYTSTE 546 Query: 556 DVSNGENKPLSDLPFHTANGTLD-WKPLAL--EDWSFYVSGHYTGQKRADSATAKT---P 609 + + +N + T L W L +D + V G Q Sbjct: 547 YLKDSQNDSGTRYSTFTPRHLLRLWSNYDLPWQDRRWSVGGGLQAQSDYSVDYRGVSMRQ 606 Query: 610 GGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRD------DYSYNEDGRRYFMAVDYRF 663 GGY + N +++ + V NL D+ + + Y E R + +++ F Sbjct: 607 GGYALVNMRLGYKIDEHWTAAVNVNNLFDRTYYQSLSNPNWNNRYGEP-RSFNVSLRGAF 665 >5NEC-A nrPDB Length = 741 Score = 164 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 116/723 (16%), Positives = 220/723 (30%), Gaps = 123/723 (17%) Query: 36 TASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQL-TNEGDNRKG--VSIR 92 + L D P S++V+ ++ ++ +L+D L+ VPG+ EG N G IR Sbjct: 39 ASKKYTAPLLDTPRSVTVVPKQVIKDTAAVSLQDALRTVPGITFGAGEGGNPTGDRPFIR 98 Query: 93 GLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGV 152 G D+ VDG R D + ++E+IEV +GP S+ G + GG Sbjct: 99 GFDAQSDT-YVDGVR-----------DTGAQTREIFNLEQIEVSKGPNSAFGGRGSAGGS 146 Query: 153 VNIITKKIGQ--------KWSGTVTVDTTI---QEHRDRGDTYNGQFFT--SGPLIDGVL 199 +N+++K+ + T T+ QE D + + + Sbjct: 147 LNLVSKQAKAGNFIDGGFTYGSDQTRRYTLDLNQEFLDGNAAFRLNLLKHDANVAGRDEV 206 Query: 200 GMKAYGSLAKREKD------------DPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQ 247 + +G ++ T D+G S+ P++ Sbjct: 207 DVSRWGVAPSLTFGLGSPTRVTVSHYHLESDDTPDSGIPYAKSSDRSKH-------NPDK 259 Query: 248 NHDFTAG--YGFDRQDRDSDSLDKNRLERQ---NYSVSHNGRWDYGTSELKYYGEKVENK 302 + G YG +D +D + + + S++ YG S Y + ++ Sbjct: 260 PVNVDRGNFYGLTGRDFQKSRIDTSTITVEHDLTDSLTIRNTSRYGNSHQDYLWTQPDDS 319 Query: 303 NPGNSSPITSESNTVDGKYTLPLTAINQFLTVGGEWR---HDKLSDAVNLTGGTSSKTSA 359 ++ S + + + TA+NQ G + + S + + S + Sbjct: 320 QGNINNG--SVWRRQNNRVSTTTTAVNQTDLFGEFYLGGFKNSFSTGLEFSREDSKRDGY 377 Query: 360 SQYALFVEDEWRIFEPLALTT-GVRMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAF 418 + L G E H + TV G A Sbjct: 378 IVDTNTGLGSNKCNPSLIGAPSGYNCTSLENPNPHDPWNGSITRKYAPLNTV--GTTKAI 435 Query: 419 KAPSLLQLSPDWTSN-SCRGACK--IVGSPDLKPETSESWELGLYYMGEEGWLEGVESSV 475 A + L+ W N R + ++P T S + + W G+ Sbjct: 436 YAFDTIDLNEQWQVNIGARFDSFETTAKNHGVRPATKLSDKSSFW-----NWQAGLVWKP 490 Query: 476 TVFRNDVKDRISISRTS--------DVNAAPGYQNFVGFETGANGRRIPVFSY------- 520 + + + NA G+ E + Sbjct: 491 VPNGSIYASYATSATPPGSMLDNGDTSNAVDGFAISNNLEPEETTNYELGTKWAFFNERL 550 Query: 521 -----------------------YNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDV 557 N ++R+ GVE ++WK+ Y+Y D V Sbjct: 551 ELSAAIFRTDKDNTRILVANQTYDNAGQSRVDGVELSASGKLTEKWKVFAGYSYLDSELV 610 Query: 558 SNGENKPLSDLP----FHTANGTLDWKPLALEDWSFYV---------SGHYTGQKRADSA 604 G+ ++ + N + + W+ Y Y + D Sbjct: 611 DAGKAGRNGNVNASAASNNGNEMPNTPKNSFSLWTTYDIFPKTTIGGGAFYVDKVYGDVG 670 Query: 605 TAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDL----SRDDYSYNEDGRRYFMAVD 660 Y ++ A+++++K+V + V N+ DK Y+ GR + + Sbjct: 671 NTVYVPDYWRYDAMASYKLSKNVDFQLNVQNVFDKKYFDKAYAAHYASQAAGRTILFSTN 730 Query: 661 YRF 663 + F Sbjct: 731 FHF 733 >3EFM-A nrPDB Length = 707 Score = 163 bits (411), Expect = 3e-40, Method: Composition-based stats. Identities = 113/695 (16%), Positives = 214/695 (30%), Gaps = 123/695 (17%) Query: 36 TASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGLD 95 TA+ + + ++ P S+SV+T++ ++ + + + +L PG+ +T NR S RG Sbjct: 39 TATGLTLSPRETPQSVSVVTRQQIEDQGLTDTGAILATAPGISVTRSDSNRYSFSARGF- 97 Query: 96 SSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNI 155 + DG V+ + + + D++ + +E+VRG + GS VN Sbjct: 98 -TIDNFQFDGL-VSPILSQWNYGSTDMD---AAIYDHVEIVRGATGLMTGSGNPSAAVNF 152 Query: 156 ITKKIGQKW--------------SGTVTVDTTIQEHR----------DRGDTYNGQFFTS 191 + K+ +++ G + I E +GD+Y T Sbjct: 153 VRKRPLREFAATFNASVGSWDYVRGDADISVPITEDGRIRSRLVAAYSQGDSYVHFLDTR 212 Query: 192 GPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGET--------PRIEGFSSRDGNVEFAW 243 GV+ + Q++ + G R + S N +A Sbjct: 213 RRTFYGVVSADLTPDTVLTTSVEYQHNHSNGFGSGFPLFYSDGSRTDFNRSVANNAPWAR 272 Query: 244 TPNQNH----DFTAGYGFDRQDRDSDSLDKNR-----LERQNYSVSHNGRWDY--GTSEL 292 + D T + D + R + S R + R Y H G S Sbjct: 273 QDTEATTYFVDLTHRFTNDWKLRAAYSHTDGRYLMKHVYRGGYPDRHTGIIAAPPAFSNY 332 Query: 293 KYYGEKVENKNPGNSSPITSESNTV---------DGKYTLPLTAINQFLTVGGEWRHDKL 343 ++ + ++ + + +G + + Sbjct: 333 DGNLDRDDIHFSLSAPFEAFGLRHEVALGWMSIDNHSDIQRYAMVGPAPAIGSFFDWRRA 392 Query: 344 SDAVNLTGGTSSKTSAS-----------QYALFVEDEWRIFEPLALTTGVRMDDHET--- 389 + + A Q ++ + + EPL L G R D +T Sbjct: 393 GSHHHHHHHIQEPSWADTLSPADDVRTKQTGAYLVGRFALAEPLHLIVGDRWSDWKTKQM 452 Query: 390 ---------YGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACK 440 ++P A L Y+ DT T + F+ + S Sbjct: 453 YFGSRREYRIKNQFTPYAGLTYDINDTYTAYASYTEIFQPQNARDTSGGI---------- 502 Query: 441 IVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGY 500 L P S+S+ELGL EG L +S +F+ + + S + P Sbjct: 503 ------LPPIKSKSYELGLKAAYLEGRL---NTSAALFQTRQDNLAQVIPGSSIPGFPNM 553 Query: 501 QNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNG 560 Q A+++G++ E +W + +YT+ +D S Sbjct: 554 QASRAASG-----------------AKVEGIDLEASGQILPDWNIGASYTHFTTKDASGN 596 Query: 561 ENKPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAK-----TPGGYTIW 615 T P AL + + + +A+ + Y + Sbjct: 597 PINTNHPRSLFKLYTTYRL-PGALHRLTVGGGVDWQSRMYQAAASPRGNVEVEQDSYALV 655 Query: 616 NTGAAWQVTKDVKLRAGVLNLGDKDLSRDDYSYNE 650 + A + K + V NL DK Y++ Sbjct: 656 SLMARFDFNKKLSATLNVNNLFDKKYYDQIGFYSQ 690 >3QLB-A nrPDB Length = 748 Score = 161 bits (406), Expect = 1e-39, Method: Composition-based stats. Identities = 145/720 (20%), Positives = 243/720 (33%), Gaps = 149/720 (20%) Query: 34 VVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRK--GVSI 91 ++ + + +L + P SISVIT++ + + VQ++ + L+ GVQ +++ +SI Sbjct: 88 SLSGTKTDASLSEIPQSISVITRDQMDAQQVQSVNEALRYTAGVQANTTAASQRFDTLSI 147 Query: 92 RGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGG 151 RG D + T +L DG + N+ A + + +ERI+V++GP S L+G ++ GG Sbjct: 148 RGFDVT-TGMLRDGLKGNTAQAWPK--------VEAYGLERIDVLKGPASVLFGQNSPGG 198 Query: 152 VVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLID-GVLGMKAYG--SLA 208 VVN I+K+ K +Q D GQF SGPL D G + G + Sbjct: 199 VVNQISKRPLDK------PFHEVQIQGGSFDRAQGQFDFSGPLDDEGQFLYRLVGLERDS 252 Query: 209 KREKDDPQNST-----------TTDTGETPRIEGFSSRDGNVEFAWTPNQNHDFTAGYGF 257 + D ++ DT T + G + P Q G Sbjct: 253 GTQFDHIKDDKQYFAPSFTWKPNDDTSLTLLADYTQDTFGAPRV-FLPAQGTLLGNPNGK 311 Query: 258 DRQDR--DSDSLDKNRL-ERQNYSVSHNGR--WDYGTSELKYYGEKVENKNPGNSSP--- 309 R + D LD +R Y + H W +S + + N G S Sbjct: 312 VRHNVFLDEPGLDNDRTQYSLGYLLEHRLNDVWSLNSSARYGHVNLLTNTASGMSLAPDL 371 Query: 310 -----------ITSESNTVDGKYTLP--LTAINQFLTVGGEWRHDKLS--------DAVN 348 I ++ ++D L + +G ++R + ++ Sbjct: 372 RTLNRAAYRFRIVGDTYSLDNNAQARWNLGSTQMVSLLGIDYRRTREDYYLRGGSASPID 431 Query: 349 LTGG-----------------TSSKTSASQYALFVEDEWRIFEPLALTTGVRMDDHE--- 388 + T++ A Q ++ + ++ E LT G R D Sbjct: 432 IYNPVHHHHHHGGVFDPSTPFTNTVQRADQVGVYAQQQFTFDEHWVLTVGGRQDRSSART 491 Query: 389 ----------TYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGA 438 E ++ R LVY A + + ++T+F P L Sbjct: 492 DNRMNDSGSKQDDEKFTYRTGLVYLADNGLAPYISYSTSFD-PVLG-------------- 536 Query: 439 CKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAP 498 G+P KP +++ E+G+ Y G++S +T+ D+ +V Sbjct: 537 TNFYGTP-YKPTSAKQSEVGVKYQP-----PGIDSYITLSLFDLT-------QENVLTTD 583 Query: 499 GYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVS 558 Q +TG R G+E E K L TYND Sbjct: 584 PAQRLNKIQTGEINVR---------------GIELEGKASLARGLDLLAALTYNDAEVSK 628 Query: 559 NGENKPLSDLPFHTANGTLD-W-----KPLALEDWSFYVSGHYTGQKRADSATAKTPGGY 612 + P T W L F Y G AD+A + Y Sbjct: 629 SNNPLEKGKRPTDTPEKMASLWADYTLPEGPLSGLGFGAGVRYIGSTEADAANTQRVPSY 688 Query: 613 TIWNTGAAWQV------TKDVKLRAGVLNLGDKDLSRDDYSYNEDG---RRYFMAVDYRF 663 T+ + + K ++L NL DK N R ++ YR+ Sbjct: 689 TLLDAAVHYDFDKLIPAAKGLRLAVNATNLTDKHYYEGCSLTNCSAGYDRSVIASLRYRW 748 >6BPM-C nrPDB Length = 727 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 124/747 (16%), Positives = 242/747 (32%), Gaps = 171/747 (22%) Query: 39 SVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKG-----VSIRG 93 + + D +++VI+++ ++ + NL D LK VPGV G+N + +RG Sbjct: 30 KFSRPVADTTRTMTVISEQVIKDQGATNLTDALKNVPGVGAFFAGENGNSTTGDAIYMRG 89 Query: 94 LDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVV 153 D+S + I +DG R D + E++EV++GP + YG A G + Sbjct: 90 ADTSNS-IYIDGIR-----------DIGSVSRDTFNTEQVEVIKGPSGTDYGRSAPTGSI 137 Query: 154 NIITKKIGQK--------WSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLID--------- 196 N+I+K+ T+ ++ GDT + G Sbjct: 138 NMISKQPRNDSGIDASASIGSAWFRRGTLDVNQVIGDTTAVRLNVMGEKTHDAGRDKVKN 197 Query: 197 ---GVLGMKAYG------------SLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEF 241 GV A+G + + D T G + G ++ + + + Sbjct: 198 ERYGVAPSVAFGLGTANRLYLNYLHVTQHNTPDGGIPTIGLPGYSAPSAGTAALNHSGKV 257 Query: 242 A---WTPNQNHDFTAGYGFDRQDRDSDSLDKNRLE--------RQNYSVS---------- 280 + + + + D D + +Q+Y ++ Sbjct: 258 DTHNFYGTDSDYDDSTTDTATMRFEHDINDNTTIRNTTRWSRVKQDYLMTAIMGGASNIT 317 Query: 281 ----HNGRWDYG-TSELKYYGEKVENKNPGNSSPITSESNTVDGKYTLPLTAINQ----- 330 W + T+ K K+ +S + S D + T Q Sbjct: 318 QPTSDVNSWTWSRTANTKDVSNKILTNQTNLTSTFYTGSIGHDVSTGVEFTRETQTNYGV 377 Query: 331 ---FLTVGGEWRHDKLSDAVNLTGGT-SSKTSASQYALFVEDEWRIFEPLALTTGVRMDD 386 L + D LT ++ +A++ D +I L G+R+D+ Sbjct: 378 NPVTLPAVNIYHPDSSIHPGGLTRNGANANGQTDTFAIYAFDTLQITRDFELNGGIRLDN 437 Query: 387 H-----------------------------------ETYGEHWSPRAYLVYNATDTVTVK 411 + G + +A +Y+ T+ V Sbjct: 438 YHTEYDSATACGGSGRGAITCPTGVAKGSPVTTVDTAKSGNLMNWKAGALYHLTENGNVY 497 Query: 412 GGWATAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGV 471 +A + + P + + + G+ D KP+ + + E+G + + + + Sbjct: 498 INYAVSQQPP-----GGNNFALAQSGSGNSANRTDFKPQKANTSEIGTKWQVLD---KRL 549 Query: 472 ESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGV 531 + +FR D+++ + + +Y K R++G Sbjct: 550 LLTAALFRTDIENEVEQNDDG--------------------------TYSQYGKKRVEGY 583 Query: 532 ETELKIPFNDEWKLSINYTYN-----DGRDVSNGENKPLSDLPFHTANGTLDWKPLALED 586 E + W++ YT +G+DV+ + L P H TL + A +D Sbjct: 584 EISVAGNITPAWQVIGGYTQQKATIKNGKDVAQDGSSSLPYTPEHAF--TLWSQYQATDD 641 Query: 587 WSFYVSGHYTGQKRADSATAKTPG----GYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLS 642 S Y G S A GY + + ++V +++ + V NL D D Sbjct: 642 ISVGAGARYIGSMHKGSDGAVGTPAFTEGYWVADAKLGYRVNRNLDFQLNVYNLFDTDYV 701 Query: 643 ----RDDYSYNEDG--RRYFMAVDYRF 663 + Y Y+ G R + + + F Sbjct: 702 ASINKSGYRYH-PGEPRTFLLTANMHF 727 >1FCP-A nrPDB Length = 705 Score = 138 bits (347), Expect = 8e-33, Method: Composition-based stats. Identities = 118/686 (17%), Positives = 227/686 (33%), Gaps = 85/686 (12%) Query: 34 VVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRK--GVSI 91 T + + ++ P SISV+T E++ +++K+ L PGV + G + + I Sbjct: 15 SATGTKTDTPIQKVPQSISVVTAEEMALHQPKSVKEALSYTPGVSVGTRGASNTYDHLII 74 Query: 92 RGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSI--ERIEVVRGPMSSLYGSDAL 149 RG + + N N + +F N +D ER E++RGP+S LYG + Sbjct: 75 RGFAAEGQS------QNNYLNGLKLQGNF-YNDAVIDPYMLERAEIMRGPVSVLYGKSSP 127 Query: 150 GGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAYGSLAK 209 GG++N+++K+ + V G ++ G + G+ + + Sbjct: 128 GGLLNMVSKRPTTEPLKEVQFKAGTDSLFQTGFDFSDSLDDDGVYSYRLTGLARSANAQQ 187 Query: 210 REKDDPQNSTTTDTGETPR-------IEGFSSRDGNVEFAWTPNQ------------NHD 250 + ++ + + P + F + + W P + D Sbjct: 188 KGSEEQRYAIAPAFTWRPDDKTNFTFLSYFQNEPETGYYGWLPKEGTVEPLPNGKRLPTD 247 Query: 251 FT--------------AGYGFDRQDRDSDSLDKNRLERQNYSVSHNGRWDYG--TSELKY 294 F GY FD + D+ ++ +N +N S N + YG + Sbjct: 248 FNEGAKNNTYSRNEKMVGYSFDHEFNDTFTVRQNLRFAEN-KTSQNSVYGYGVCSDPANA 306 Query: 295 YGEKVENKNPGNSSPITSESNTVDGK--YTLPLTAINQFLTVGGEWRHDKLSDAVNLTGG 352 Y ++ P + + VD + + Q G+ D LTG Sbjct: 307 YSKQCAALAPADKGHYLARKYVVDDEKLQNFSVDTQLQSKFATGD------IDHTLLTGV 360 Query: 353 TSSKTSASQYALFVEDE----WRIFEPLALTTGVRMDDHETYGEHWSPRAYLVYNATDTV 408 + A F D+ ++ P + + P Y + Sbjct: 361 DFMRMRNDINAWFGYDDSVPLLNLYNPSHHHHHHGSVNTDFDFNAKDPANSGPYRILNKQ 420 Query: 409 TVKGGWA--TAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEG 466 G + A L+ L + ++ G+ D + + +W G+ Y+ + G Sbjct: 421 KQTGVYVQDQAQWDKVLVTLGGRYDWADQESLNRVAGTTDKRDDKQFTWRGGVNYLFDNG 480 Query: 467 WLEGVESSVTV--FRNDVKD------------RISISRTSDVNAAPGYQNFVGFETGANG 512 S + KD + + + N Sbjct: 481 VTPYFSYSESFEPSSQVGKDGNIFAPSKGKQYEVGVKYVPEDRPIVVTGAVYNLTKTNNL 540 Query: 513 RRIPVFSYYNV--NKARIQGVETELKIPFNDEWKLSINYTYNDGRDV--SNGENKPLSDL 568 P S+++V + R +GVE E K + + +YTY D + + + + Sbjct: 541 MADPEGSFFSVEGGEIRARGVEIEAKAALSASVNVVGSYTYTDAEYTTDTTYKGNTPAQV 600 Query: 569 PFHTANGTLDWKPLA--LEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTK- 625 P H A+ D+ L + G YTG D A + G YT+ + + + + Sbjct: 601 PKHMASLWADYTFFDGPLSGLTLGTGGRYTGSSYGDPANSFKVGSYTVVDALVRYDLARV 660 Query: 626 ---DVKLRAGVLNLGDKDLSRDDYSY 648 + V NL D++ ++ Sbjct: 661 GMAGSNVALHVNNLFDREYVASCFNT 686 >4RDT-A nrPDB Length = 748 Score = 130 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 130/757 (17%), Positives = 242/757 (31%), Gaps = 152/757 (20%) Query: 29 DGETMVVTASSVEQN----LKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGD 84 D ET+ V S + L + AS +I+ + L++K V NL D L VPG+ + G Sbjct: 22 DLETVSVVGKSRPRATSGLLHTSTASDKIISGDTLRQKAV-NLGDALDGVPGIHASQYGG 80 Query: 85 NRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNW-IPVDSI--ERIEVVRGPMS 141 IRG +L N DF + I VD+ +++E++RGP++ Sbjct: 81 GASAPVIRGQTGRRIKVL------NHHGETGDMADFSPDHAIMVDTALSQQVEILRGPVT 134 Query: 142 SLYGSDALGGVVNIITKKIGQKWS------------GTVTVDTTIQEHRDRGDTYNGQFF 189 LY S + G+V++ KI +K + ++ + G N Sbjct: 135 LLYSSGNVAGLVDVADGKIPEKMPENGVSGELGLRLSSGNLEKLTSGGINIGLGKNFVLH 194 Query: 190 TSG-PLIDGVLGMKAYGSLAKREKDDPQNSTTTDT---GETPRIEGFSSRDGNVEFAWTP 245 T G G + Y +L + + T + G + D ++ P Sbjct: 195 TEGLYRKSGDYAVPRYRNLKRLPDSHADSQTGSIGLSWVGEKGFIGVAYSDRRDQYGL-P 253 Query: 246 NQNHDFTAGYGF----------------------DRQDRDSDSLDKNRLERQN-YSVSHN 282 +H++ + + D D+ L + N ++ +H+ Sbjct: 254 AHSHEYDDCHADIIWQKSLINKRYLQLYPHLLTEEDIDYDNPGLSCGFHDDDNAHAHTHS 313 Query: 283 GRWDYGTSELKYYGEKVENKNP----------------------GNSSPITSESNTVDGK 320 GR + K Y + E K P G++ + T + + Sbjct: 314 GR-PWIDLRNKRYELRAEWKQPFPGFEALRVHLNRNDYRHDEKAGDAVENFFNNQTQNAR 372 Query: 321 YTLPLTAINQFL-TVGGEWRHDKLSDAVNLTGGTSSKT----SASQYALFV--EDEWRIF 373 L I + + G ++ K S ++ Y+ F + W Sbjct: 373 IELRHQPIGRLKGSWGVQYLQQKSSALSAISEAVKQPMLLDNKVQHYSFFGVEQANW--- 429 Query: 374 EPLALTTGVRMD-------------DHETYGEHWSPRAYLVYNATDTVTVKGGW------ 414 + L GVR++ D E Y H P + + G W Sbjct: 430 DNFTLEGGVRVEKQKASIQYDKALIDRENYYNHPLPDLGAHRQTARSFALSGNWYFTPQH 489 Query: 415 ------ATAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWL 468 + + PS +L VG+ L E S + EL L Y G+ W Sbjct: 490 KLSLTASHQERLPSTQELYAHGKH--VATNTFEVGNKHLNKERSNNIELALGYEGDR-W- 545 Query: 469 EGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARI 528 + ++ ++RN + I +D ++ + YN + A Sbjct: 546 ---QYNLALYRNRFGNYIYAQTLNDGRGPKSIEDDSEMK----------LVRYNQSGADF 592 Query: 529 QGVETELKIPFNDEWKLSINYTYNDGRDV----SNGENKPLSDLPFHTANGTLDWKPLAL 584 G E E+ +++ ++ Y GR G + PF + + + Sbjct: 593 YGAEGEIYFKPTPRYRIGVSGDYVRGRLKNLPSLPGREDAYGNRPFIAQDDQ-NAPRVPA 651 Query: 585 EDWSFYVSGHYTGQKRADSATAKT------------PGGYTIWNTGAAWQVTKDV---KL 629 F++ T + A+ + G+ + N GA ++ Sbjct: 652 ARLGFHLKASLTDRIDANLDYYRVFAQNKLARYETRTPGHHMLNLGANYRRNTRYGEWNW 711 Query: 630 RAGVLNLGDKDLSRD-DYSYNED--GRRYFMAVDYRF 663 NL ++ + + + GR + V+ +F Sbjct: 712 YVKADNLLNQSVYAHSSFLSDTPQMGRSFTGGVNVKF 748 >3CSL-A nrPDB Length = 865 Score = 121 bits (302), Expect = 1e-27, Method: Composition-based stats. Identities = 129/783 (16%), Positives = 246/783 (31%), Gaps = 165/783 (21%) Query: 29 DGETMVVTASSVEQN-LKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRK 87 D T++ + + + D P S+SVI++E + +P ++ D+L++ G + + Sbjct: 100 DSLTVLGAGGNNANDWVYDEPRSVSVISREQMDNRPARHAADILEQTTGAYSSVSQQDPA 159 Query: 88 -GVSIRG-LDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYG 145 V+IRG D + +DG R N + + + + +I + + + + +G + Sbjct: 160 LSVNIRGIQDYGRVNMNIDGMRQNFQKSGHGQRNGTM-YIDSELLSGVTIDKGTTGGMGS 218 Query: 146 SDALGGVVNIITKKIGQKWSGTVTVDTTIQEHRDRGDTY---NGQFFTSGPLIDGVLGM- 201 + LGG+ T + + + T+ +G D +L Sbjct: 219 AGTLGGIATFNTVSASDFLAPGKELGGKLHASTGDNGTHFIGSGILALGNETGDILLAAS 278 Query: 202 -KAYGSLAKREKDDPQN-STTTDTGETPRIEG-----------FSSRDGNVEFAWTPNQN 248 + G K D N DTG R + + W N Sbjct: 279 ERHLGDYWPGNKGDIGNIRINNDTGNYDRYAESIKNNKIPDTHYRMHSRLAKVGWNLPAN 338 Query: 249 HDFTAGYGFDRQDRDSDSLDKNRLERQNYSVSHNG----------------------RWD 286 Y + N R Y + W Sbjct: 339 QRLQLSYLQTQTASPIAGTLTNLGTRPPYELGWKRTGYTDVMARNAAFDYSLAPEDVDWL 398 Query: 287 YGTSELKYYGEKVENKNPGNSSPITSESNTVDGKYTLPLTAINQFL-----------TVG 335 ++L Y + ++ SS + + T T A N G Sbjct: 399 DFQAKLYYVDTQDDSDTYSTSSLLDNGYATRTRLRTYGAQAQNTSRFSLAPGHDFRANYG 458 Query: 336 GEWRHDKLSDAVNLTG--GTSSKTSASQYALFVEDEWRIFEPLALTTGVRMDDHETYG-- 391 E+ +DK + + G G + + S +LF + L L G+R D + G Sbjct: 459 LEFYYDKATSDSSRQGMEGVTPAGNRSVASLFANLTYDYDGWLTLEGGLRYDRYRLRGQT 518 Query: 392 ---------------------------------EHW---------SPRAYLVYNAT-DTV 408 E W SP + + + Sbjct: 519 GLSYPDLAKDGQRYTIDNPCKALRLTGCSTTTREDWDVDRDQGKLSPTLAVAVRPGVEWL 578 Query: 409 TVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWL 468 + + +++ P++ + + +++S +P L+PE S +WE+G + W Sbjct: 579 ELYTTYGKSWRPPAITETLTNGSAHSSSTQ---YPNPFLQPERSRAWEVGFNVQQPDLWF 635 Query: 469 EG--VESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKA 526 EG + + V F V + I+++ D N Q +G N N++K Sbjct: 636 EGDRLVAKVAYFDTKVDNYINLA--IDRNKPGLVQPSIGNAAYVN----------NLSKT 683 Query: 527 RIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKPLSDLPFH---TANGTLDWKPLA 583 R +G+E +L + + YT+ G++ L + + G +P A Sbjct: 684 RFRGLEYQLNYD-AGVFYADLTYTHMIGKNEFCSNKAWLGGRLRYGDGSRRGNFYVEPDA 742 Query: 584 LED---------------------WSFYVSGHYTGQKRADSATAKTPGG----------- 611 + S + G +K T + G Sbjct: 743 ASNDFVTCDGGTQFGSAAYLPGDRGSVTLGGRAFDRKLDAGVTVRFAPGYQDSSVPSNYP 802 Query: 612 -------YTIWNTGAAWQVTKDVKLRAGVLNLGDKDLS----RDDYSYNEDGRRYFMAVD 660 YT+++ A++++T + LR V NL ++ + GR V+ Sbjct: 803 YLADWPKYTLFDLYASYKLTDSLTLRGSVENLTNRAYVVSYGETLANTLGRGRTVQGGVE 862 Query: 661 YRF 663 YRF Sbjct: 863 YRF 865 >4AIP-A nrPDB Length = 742 Score = 98.1 bits (242), Expect = 1e-20, Method: Composition-based stats. Identities = 96/732 (13%), Positives = 202/732 (27%), Gaps = 142/732 (19%) Query: 31 ETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVS 90 +T+ V ++ +++T + +++++LKE P + + ++ Sbjct: 54 DTVTVKGDRQGSKIRT-----NIVTLQQKDESTATDMRELLKEEPSIDFGGGNGTSQFLT 108 Query: 91 IRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALG 150 +RG+ + I VD +S ++ F ++ ++ + V +G S+ G A Sbjct: 109 LRGMGQNSVDIKVDNAYSDS-QILYHQGRFIVD---PALVKVVSVQKGAGSASAGIGATN 164 Query: 151 GVVNIITKKIGQKWSG---TVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAYGSL 207 G + T G V + G +Y F DG+ Y Sbjct: 165 GAIIAKTVDAQDLLKGLDKNWGVRLNSGFASNNGVSYGASVFGKEGNFDGLFS---YNRN 221 Query: 208 AKREKDDPQNSTTTDTGETPRIEGFSSRDGNVEFAWTPNQN------------------- 248 +++ + + + G+T R + T + Sbjct: 222 DEKDYEAGKGFRNVNGGKTVPYSALDKRSYLAKIGTTFGDDDHRIVLSHMKDQHRGIRTV 281 Query: 249 -HDFTAGYGFDRQDRDSDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNS 307 +FT G R + D + + N ++++ G+ +L +E + Sbjct: 282 REEFTVGDKSSRINIDRQAPAYRETTQSNTNLAYTGKNLGFVEKLDANAYVLEKERYSAD 341 Query: 308 SPITSESNTVDG-----------KYTLPLTAINQFLT-VGGEWRHDKLS----------- 344 T + V G + Q L G +RH ++ Sbjct: 342 DSGTGYAGNVKGPNHTRITTRGANFNFDSRLAEQTLLKYGINYRHQEIKPQAFLNSKFSI 401 Query: 345 --DAVNLTGGTSSKTSASQYALFVEDE---WRIFEPL-----------------ALTTGV 382 ED +++ P LT G+ Sbjct: 402 PTTEEKNGQKVDKPMEQQMKDRADEDTVHAYKLSNPTKTDTGVYIEAIHDIGDFTLTGGL 461 Query: 383 RMDDH--------ETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNS 434 R D + +P +++ + + A ++P L Sbjct: 462 RYDRFKVKTHDGKTVSSSNLNPSFGVIWQPHEHWSFSASHNYASRSPRLYDALQTHGKRG 521 Query: 435 CRGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDV 494 + K E + + E+G Y G + F +KD + Sbjct: 522 IISI-----ADGTKAERARNTEIGFNYNDGTFAANG-----SYFWQTIKDAL-------- 563 Query: 495 NAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTYNDG 554 + V N + G E + +++ Sbjct: 564 -----------ANPQNRHDSVAVREAVNAGYIKNHGYELGASYR-TGGLTAKVGVSHSKP 611 Query: 555 RDVSNGENKPLSDLPFH------TANGTLDWKPLALEDWSFYVSGHY-----------TG 597 R ++K LS P T +L ++ + G Y Sbjct: 612 RFYDTHKDKLLSANPEFGAQVGRTWTASLAYRFQNP-NLEIGWRGRYVQKATGSILAAGQ 670 Query: 598 QKRADSATAKTPGGYTIWNTGAAWQ--VTKDVKLRAGVLNLGDKDLSRDD----YSYNED 651 + R + G+ + + A W+ + + V N+ +K + Sbjct: 671 KDRKGNLENVVRKGFGVNDVFANWKPLGKDTLNVNLSVNNVFNKFYYPHSQRWTNTLPGV 730 Query: 652 GRRYFMAVDYRF 663 GR + V+Y+F Sbjct: 731 GRDVRLGVNYKF 742 >4B7O-A nrPDB Length = 745 Score = 94.2 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 97/734 (13%), Positives = 205/734 (27%), Gaps = 143/734 (19%) Query: 31 ETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKGVS 90 +T+ V ++ +++T + +++++LKE P + + ++ Sbjct: 54 DTVTVKGDRQGSKIRT-----NIVTLQQKDESTATDMRELLKEEPSIDFGGGNGTSQFLT 108 Query: 91 IRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALG 150 +RG+ + I VD +S ++ F ++ ++ + V +G S+ G A Sbjct: 109 LRGMGQNSVDIKVDNAYSDS-QILYHQGRFIVD---PALVKVVSVQKGAGSASAGIGATN 164 Query: 151 GVVNIITKKIGQKWSG---TVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAYGSL 207 G + T G V + G +Y F DG+ Y Sbjct: 165 GAIIAKTVDAQDLLKGLDKNWGVRLNSGFASNEGVSYGASVFGKEGNFDGLFS---YNRN 221 Query: 208 AKREKDDPQNSTTTDTGETPRIEGFSSR-----------DGNVEFAWTPNQNH------- 249 ++E + + + G+T R DG+ + ++ Sbjct: 222 DEKEYEAGKGFRNFNGGKTVPYSALDKRSYLAKIGTTFGDGDHRIVLSHMEDQHRGIRTV 281 Query: 250 --DFTAGYGFDRQD--RDSDSLDKNRLERQNYSVSHN--GRWDYGTSELKYYGEKV---E 300 +FT G R + R + + N + + G + + +K + Sbjct: 282 REEFTVGDASSRTNITRQAPPYRETTQSNTNLAYTGKDLGFVEKLDANAYVLEKKRYSAD 341 Query: 301 NKNPGNSSPITSESN----TVDGKYTLPLTAINQFLT-VGGEWRHDKLSDAVNLTG---- 351 +K+ G + + ++ T + Q L G +RH ++ L G Sbjct: 342 DKDNGYAGNVVGPNHTRITTRGMNFNFDSRLAEQTLLKYGINYRHQEIKPQAFLNGEFEI 401 Query: 352 ---------------GTSSKTSASQYALFVEDEWRIFEPL-----------------ALT 379 T + + + + + +++ P LT Sbjct: 402 SGKKKDPKDPKKEIDKTDEEKAKDKKDMDLVHSYKLSNPTKTDTGAYIEAIHELDGFTLT 461 Query: 380 TGVRMDDH--------ETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWT 431 G+R D + +P +++ + + A ++P L Sbjct: 462 GGLRYDRFKVKTHDGKTVSSSNLNPSFGVIWQPHEHWSFSSSHNYASRSPRLYDALQTHG 521 Query: 432 SNSCRGACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRT 491 + K E + + E+G Y G + F +KD + Sbjct: 522 KRGIISI-----ADGTKAERARNTEIGFNYNDGTFAANG-----SYFWQTIKDAL----- 566 Query: 492 SDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKLSINYTY 551 V N + G E + ++ Sbjct: 567 --------------ANPQNRHVSAAVREAVNAGYIKNHGYELGASYR-TGGLTAKVGVSH 611 Query: 552 NDGRDVSNGENKPLSDLPFHTANGTLDWKPLALEDW-----SFYVSGHY----------- 595 + R K LS P A W + G Y Sbjct: 612 SKPRFYDTHPKKLLSANPEFGAQVGRAWTASLAYRFQNPNLEIGWRGRYVQKAVGSILVA 671 Query: 596 TGQKRADSATAKTPGGYTIWNTGAAWQ--VTKDVKLRAGVLNLGDKDLSRDD----YSYN 649 + R G+ + + A W+ + + V N+ + + Sbjct: 672 GQKDRNGKLENVVRKGFGVNDVFANWKPLGKDTLNVNLSVNNVFNTFYYPHSQRWTNTLP 731 Query: 650 EDGRRYFMAVDYRF 663 GR + V+Y+F Sbjct: 732 GVGRDVRLGVNYKF 745 >6H7F-A nrPDB Length = 706 Score = 90.4 bits (222), Expect = 3e-18, Method: Composition-based stats. Identities = 113/729 (15%), Positives = 219/729 (30%), Gaps = 131/729 (17%) Query: 20 AWPVLAVDDDGETMVVTASSVEQN---------LKDAPASISVITQEDLQRKPVQNLKDV 70 A P + V + + + D P + T + ++ K +++ +V Sbjct: 24 ALPAITVKAEQDDTYAGGQVATSSNVGFLGSKKFLDTPFNTISYTDKYIEDKQAKDITEV 83 Query: 71 LK-EVPGVQLTN-EGDNRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVD 128 + P + G + IRG SS + ++G + Sbjct: 84 IAATDPSIYTNGASGGWSENYYIRGYASSTNDMSMNGL----------FGITPFYRTSPE 133 Query: 129 SIERIEVVRGPMSSLYG---SDALGGVVNIITKKIGQK--------------WSGTVTVD 171 R+EV++GP + L G + ++GG VN++TK + + G V V Sbjct: 134 MFGRVEVLKGPSALLNGMPPAGSVGGTVNLVTKYAADEPFARLTTTYMSDAQFGGHVDVG 193 Query: 172 TTIQEHRDRGDTYNGQF-FTSGPLIDGVLGMK------------------AYGSLAKREK 212 E+++ G NG + + D + AY +L + Sbjct: 194 RRFGENKEFGVRINGMYRDGDAAVNDQSKESRLFSLGLDWQGENARVFVDAYDALDHVDG 253 Query: 213 DDPQNSTTTDTG----------ETPRIEGFSSRDGNVEFAWTPNQNHDFT--AGYGFDRQ 260 + +T G +P ++D + + A YG Sbjct: 254 VTRGVNVSTAVGIPKPPKADTLLSPDWGSVETKDKGAMIRGEYDFSDQLMAYAAYGQSTT 313 Query: 261 DRDSDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPI------TSES 314 + + + ++S + K + K S T + Sbjct: 314 EYKYNGASAGTITSSTGTLSSTLGQLAFDVDKKSADAGFKGKFETGSVKHQWVANATYYN 373 Query: 315 NTVDGKY-----TLPLTAINQFLTVGGEWRHDKLSDAVNLTGGTSSKTSASQYALFVEDE 369 +T D I W L T S +S + Sbjct: 374 HTQDDYGYRIIPGFSDPVITNIYDPNPNWGPKPEFTPPFLFHSTLSTSSF----GLADTL 429 Query: 370 WRIFEPLALTTGVRMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKAPSLLQLSPD 429 + + LT G+R H+T + S L NA T G A KA + + + Sbjct: 430 SFAQDKVQLTLGLR---HQTV-KATSSVNTLPENAKSATT--PGVALLIKATDKISVYAN 483 Query: 430 WTSNSCRG----ACKIVGSPDLKPETSESWELGLYYMGEEGWLEGVESSVTVFRNDVKDR 485 + +G A P+ ++ ELGL D Sbjct: 484 YIEGLTKGDQAPATASNPGEIFPPQKTKQQELGLKV----------------------DL 521 Query: 486 ISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETELKIPFNDEWKL 545 + + T +++ N + ++ + + R +G+E + +L Sbjct: 522 GTFAHTLSAFEITKPSSYLDPSKLVNN----LPTFVSDGEQRNRGIEWSFFGSPIEHVRL 577 Query: 546 SINYTYNDGRDVSN---GENKPLSD-LPFHTANGTLDWKPLALED-WSFYVSGHYTGQKR 600 +TY D G + + +P + A +W + + + + ++ Sbjct: 578 MGGFTYLDPELTKTKSGGNDGHTAVAVPKNQAKLGAEWDTQVAQGTLTLSGNINAVSKQY 637 Query: 601 ADSATAKTPGGYTIWNTGAAW--QVTKD-VKLRAGVLNLGDKDLSRDDYSYN---EDGRR 654 ++ + G T+ + GA + +V V RA + NL +K N R Sbjct: 638 INAENTLSVPGRTLLDVGARYSTKVEDHPVTFRANIYNLTNKAYWAQPQLTNLALGAPRT 697 Query: 655 YFMAVDYRF 663 Y ++V Y F Sbjct: 698 YMLSVSYDF 706 >3V8X-A nrPDB Length = 904 Score = 89.6 bits (220), Expect = 4e-18, Method: Composition-based stats. Identities = 79/434 (18%), Positives = 131/434 (30%), Gaps = 96/434 (22%) Query: 293 KYYGEKVENKNPGNSSPITSESNTVDGKYTLPLTAINQFLTVGGEWRHDKLSDAVNLTGG 352 YY + + + +G T P ++T+G R + ++ + G Sbjct: 504 YYYQHANRAYSSNTPPQNNGKKISPNGSETSP-----YWVTIG---RGNVVTGQICRLGN 555 Query: 353 TSSKTSASQ------YALFVEDEWRIFEPLALTTGVRMD---DHETYG-------EHWSP 396 + + Y V D R+ + G+R D H G S Sbjct: 556 NTYTDCTPRSINGKSYYAAVRDNVRLGRWADVGAGLRYDYRSTHSDDGSVSTGTHRTLSW 615 Query: 397 RAYLVYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWE 456 A +V TD + + +T F+ PS ++ + + + PE S + E Sbjct: 616 NAGIVLKPTDWLDLTYRTSTGFRLPSFAEMYGWRAGVQSK-------AVKIDPEKSFNKE 668 Query: 457 LGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIP 516 G+ + G+ G + F N +D I + + G + G Sbjct: 669 AGIVFKGDFG-----NLEASWFNNAYRDLIVRGYEAQI--KDGKEEAKGDPA-------- 713 Query: 517 VFSYYNVNKARIQGVETELKIPFNDEWK-----LSINYTYNDGRDVSNGENKPLSDLPFH 571 Y N ARI G+ KI +N W + YN R + +D+ H Sbjct: 714 ---YLNAQSARITGINILGKIDWNGVWDKLPEGWYSTFAYNRVRVRDIKKRADRTDIQSH 770 Query: 572 -----------------------TANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAKT 608 NG L + G R ATA+ Sbjct: 771 LFDAIQPSRYVVGLGYDQPEGKWGVNGMLTYSKAKEITELLGSRALLNGNSRNTKATARR 830 Query: 609 PGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDL--SRDD-----------------YSYN 649 + I + + V K LRAGV NL + + Y Sbjct: 831 TRPWYIVDVSGYYTVKKHFTLRAGVYNLLNYRYVTWENVRQTAGGAVNQHKNVGVYNRYA 890 Query: 650 EDGRRYFMAVDYRF 663 GR Y +++Y+F Sbjct: 891 APGRNYTFSLEYKF 904 Score = 85.4 bits (209), Expect = 8e-17, Method: Composition-based stats. Identities = 32/119 (26%), Positives = 56/119 (47%), Gaps = 9/119 (7%) Query: 53 VITQEDLQRKPVQNLKDVLKEVPGVQLTNEG-DNRKGVSIRGLDSSYTLILVDGK-RVNS 110 V + + L ++ V N++D+ + PG+ + +G G SIRG+D + + VDG ++ S Sbjct: 51 VKSSDTLSKEQVLNIRDLTRYDPGIAVVEQGRGASSGYSIRGMDKNRVSLTVDGVSQIQS 110 Query: 111 RNAVFRHN-------DFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITKKIGQ 162 A +N I ++++ +E+ +G S GS AL G V TK Sbjct: 111 YTAQAALGGTRTAGSSGAINEIEYENVKAVEISKGSNSVEQGSGALAGSVAFQTKTADD 169 >5FQ8-B nrPDB Length = 984 Score = 53.4 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 114/308 (37%), Gaps = 39/308 (12%) Query: 31 ETMVVTASSVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKE-VPGVQLTNEGDNR--- 86 + +VVTA ++++ K + + + E + ++ L + GVQ+++ + Sbjct: 24 DEVVVTAMGIKRSEKALGYAATSVGGEKIAESRTSDVMSSLAGKIAGVQISSTSSDPGAS 83 Query: 87 KGVSIRGLDS----SYTLILVDGKRVNS--------RNAVFRHNDFDLNWIPVDSIERIE 134 V IRG+ S + L +VDG +N+ N+ + + N I D + + Sbjct: 84 NSVIIRGVSSLSGTNQPLYVVDGVPLNNSTVYSTDGLNSGYDFGNGA-NAINPDDVANMT 142 Query: 135 VVRGPMS-SLYGSDALGGVVNIITKKIGQK------------WSGTVTVDTTIQEHRDRG 181 +++G + +LYGS A GVV I TK ++ WS + + E Sbjct: 143 ILKGAAATALYGSRAANGVVMITTKSGRKEKGVGIEYNGGVQWSTVLRLPEFQNEFGMGW 202 Query: 182 DTYNGQFFTS--GPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNV 239 + + + GP DG M+ +G++ + D + GF + Sbjct: 203 NGNHTELENGSWGPRFDG--SMQLWGNVYNNSQKLKPYVAMPDNIKDFFDAGFRYSNSLS 260 Query: 240 EFAWTPNQN--HDFTAGYGFDRQDRDSDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGE 297 T + F+ D+DS DK + SH +S L Y + Sbjct: 261 FNGATDKSDYYVSFSQISDDGMIPTDADSYDKYTF---SARGSHKAGALTFSSSLNYAYQ 317 Query: 298 KVENKNPG 305 K G Sbjct: 318 KNNFATTG 325 Score = 29.5 bits (64), Expect = 4.4, Method: Composition-based stats. Identities = 30/154 (19%), Positives = 52/154 (33%), Gaps = 26/154 (16%) Query: 406 DTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYMGEE 465 D V +A + L+ + A ++GS L PE + E+GL Sbjct: 599 DVYMVNPVYAQSSNRIPFGSLTFPLGGVNAYSAGNVLGSNTLSPEMTTESEVGLNMAF-- 656 Query: 466 GWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNK 525 + + V+ + N D+ S D + QN N+ K Sbjct: 657 -FKNRLSFDVSYY-NRNTDKQIFSLAMDPASGYTAQNM------------------NLGK 696 Query: 526 ARIQGVETELKIPFNDE----WKLSINYTYNDGR 555 R +G+E + W+L+ N+T N + Sbjct: 697 IRNRGIELLISGTPIRTKDFSWELTWNFTKNWSK 730 >5O9C-C nrPDB Length = 354 Score = 35.7 bits (80), Expect = 0.059, Method: Composition-based stats. Identities = 24/193 (12%), Positives = 51/193 (26%), Gaps = 4/193 (2%) Query: 457 LGLYYMGEEGWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQNFVGFETGANGRRIP 516 L Y G+ G + G + + ++ + + G + + Sbjct: 146 FALQYQGKNGSVSGEDQTNNGRDFQKQNGEGFGTSVTYDIWDGISAGFAYSSSKRTDEQN 205 Query: 517 VFSYYNVNKARIQGV--ETELKIPFNDEWKLSINYTYNDGRDVSNGENKPLSDLPFHTAN 574 ++ + GV E + + K N Y + ++ F Sbjct: 206 NSTFVSKTDGGRYGVLGEGDHAETYTGGLKYDANNIYLATQYTQTYNATRTGNIGFANKA 265 Query: 575 GTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLRA--G 632 + D+ S Y K D + GA + K++ Sbjct: 266 QNFEVVAQYQFDFGLRPSVAYLQSKGKDMGRYGDQDILKYVDLGATYYFNKNMSTYVDYK 325 Query: 633 VLNLGDKDLSRDD 645 + L D ++D Sbjct: 326 INLLDDNKFTKDA 338 >4KQQ-A nrPDB Length = 564 Score = 32.6 bits (72), Expect = 0.50, Method: Composition-based stats. Identities = 27/169 (15%), Positives = 56/169 (33%), Gaps = 21/169 (12%) Query: 480 NDVKDR----ISISRTSDVNAAPGYQNFVGFETGANGRRIPVFSYYNVNKARIQGVETEL 535 DV DR I ++ + PG + + G + + V K ++ L Sbjct: 153 TDVDDRGREGIELAFDEWLAGVPGKRQVLKDRRGRVIKDVQVTKNAKPGKTLALSIDLRL 212 Query: 536 KIPFNDEWKLSINYTYNDGR-------DVSNGENKPLSDLPFHTANGTLDWKPLALEDWS 588 + + E + N + DV GE +++ P + N + +P A+ + + Sbjct: 213 QYLAHRELR--NALLENGAKAGSLVIMDVKTGEILAMTNQPTYNPNNRRNLQPAAMRNRA 270 Query: 589 FYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLG 637 + + P + W+ + V + G L +G Sbjct: 271 MIDVF--------EPGSTVKPFSMSAALASGRWKPSDIVDVYPGTLQIG 311 >1OSM-A nrPDB Length = 342 Score = 31.4 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 17/117 (14%), Positives = 28/117 (23%), Gaps = 2/117 (1%) Query: 531 VETELKIPFNDEWKLSINYTYNDGRDVSNGENKPLSDLPFHTANGTLDWKPLALEDWSFY 590 E + + K N Y + L F + D+ Sbjct: 210 GEGDHAETYTGGLKYDANNIYLATQYTQTYNATRAGSLGFANKAQNFEVAAQYQFDFGLR 269 Query: 591 VSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLRA--GVLNLGDKDLSRDD 645 S Y K D + GA + K++ + L D +R Sbjct: 270 PSVAYLQSKGKDLNGYGDQDILKYVDVGATYYFNKNMSTYVDYKINLLDDNSFTRSA 326 >1QD5-A nrPDB Length = 275 Score = 31.1 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 15/91 (16%), Positives = 30/91 (32%), Gaps = 2/91 (2%) Query: 545 LSINYTYNDGRDVSNGENKPLSDLPFHTANGTLDWKPLALED--WSFYVSGHYTGQKRAD 602 S ++ R ++ N + P++ T D + + + H + Sbjct: 157 TSRSWNRLYTRLMAENGNWLVEVKPWYVVGNTDDNPDITKYMGYYQLKIGYHLGDAVLSA 216 Query: 603 SATAKTPGGYTIWNTGAAWQVTKDVKLRAGV 633 GY G ++ +TK V+L V Sbjct: 217 KGQYNWNTGYGGAELGLSYPITKHVRLYTQV 247 >1GFN-A nrPDB Length = 334 Score = 30.7 bits (67), Expect = 2.1, Method: Composition-based stats. Identities = 32/170 (18%), Positives = 54/170 (31%), Gaps = 12/170 (7%) Query: 466 GWLEGVESSVTVFRNDVKDRISISRTSDVNAAPGYQ----NFVGFETGANGRRIPVFSYY 521 G ++G+ +V + +D S V + Y+ VG A+ + Sbjct: 140 GLVDGLNFAVQYLGKNERDTARRSNGDGVGGSISYEYEGFGIVGAYGAADRTNLQEAQPL 199 Query: 522 NVNKARIQGVETELKIPFNDEWKLSINYTYNDGRDVSNGENKPLSDLPFHTANGTLDWKP 581 K + + T LK + L+ NY + S AN T D Sbjct: 200 GNGK-KAEQWATGLKYD-ANNIYLAANYGETRNATPITNKFTNTSGF----ANKTQDVLL 253 Query: 582 LALEDWSFYV--SGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKL 629 +A + F + S YT K D + GA + K++ Sbjct: 254 VAQYQFDFGLRPSIAYTKSKAKDVEGIGDVDLVNYFEVGATYYFNKNMST 303 >1QD6-C nrPDB Length = 240 Score = 30.3 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 15/91 (16%), Positives = 30/91 (32%), Gaps = 2/91 (2%) Query: 545 LSINYTYNDGRDVSNGENKPLSDLPFHTANGTLDWKPLALED--WSFYVSGHYTGQKRAD 602 S ++ R ++ N + P++ T D + + + H + Sbjct: 122 TSRSWNRLYTRLMAENGNWLVEVKPWYVVGNTDDNPDITKYMGYYQLKIGYHLGDAVLSA 181 Query: 603 SATAKTPGGYTIWNTGAAWQVTKDVKLRAGV 633 GY G ++ +TK V+L V Sbjct: 182 KGQYNWNTGYGGAELGLSYPITKHVRLYTQV 212 >2EBS-A nrPDB Length = 789 Score = 28.7 bits (62), Expect = 9.0, Method: Composition-based stats. Identities = 16/58 (27%), Positives = 23/58 (39%), Gaps = 8/58 (13%) Query: 284 RWDYGTSELKYYGEKVENKNPG--NSSPITSESNTVDGKYTLPLTAINQFLTVGGEWR 339 RWD GTS+ + +E ++ + I + N D Y Q VG EW Sbjct: 41 RWDAGTSKWIPLNDFIEAQDMNIMGTESIALDPNNPDRLYLA------QGRYVGDEWA 92 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.302 0.113 0.267 Lambda K H 0.267 0.0346 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 21,451,382 Number of Sequences: 36641 Number of extensions: 830513 Number of successful extensions: 1802 Number of sequences better than 10.0: 36 Number of HSP's better than 10.0 without gapping: 53 Number of HSP's successfully gapped in prelim test: 22 Number of HSP's that attempted gapping in prelim test: 1482 Number of HSP's gapped (non-prelim): 117 length of query: 663 length of database: 10,336,785 effective HSP length: 103 effective length of query: 560 effective length of database: 6,562,762 effective search space: 3675146720 effective search space used: 3675146720 T: 11 A: 40 X1: 16 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.5 bits) S2: 62 (28.7 bits)