BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P17157 (305 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4KRC-A nrPDB 635 0.0 2BPM-A nrPDB 342 2e-94 4AU8-A nrPDB 333 4e-92 1V0B-A nrPDB 332 9e-92 3NIZ-A nrPDB 322 1e-88 5G6V-A nrPDB 319 1e-87 6GU6-A nrPDB 306 6e-84 3GC0-A nrPDB 283 5e-77 1UA2-A nrPDB 236 1e-62 1G3N-A nrPDB 227 5e-60 5EFQ-A nrPDB 225 2e-59 2W96-B nrPDB 224 3e-59 4NST-A nrPDB 216 8e-57 3MIA-A nrPDB 211 2e-55 4AGU-A nrPDB 204 4e-53 4BBM-A nrPDB 201 3e-52 3ZDU-A nrPDB 194 4e-50 4ZSG-A nrPDB 188 2e-48 4IC8-A nrPDB 187 4e-48 4QTB-A nrPDB 184 5e-47 4BGQ-A nrPDB 182 1e-46 2F9G-A nrPDB 182 2e-46 4EWQ-A nrPDB 181 5e-46 4CRL-A nrPDB 181 5e-46 5NGU-A nrPDB 179 2e-45 3OZ6-A nrPDB 178 3e-45 6DTL-A nrPDB 178 3e-45 1CM8-A nrPDB 178 3e-45 4O2Z-A nrPDB 176 9e-45 4MYG-A nrPDB 176 1e-44 3OHT-A nrPDB 174 3e-44 3GC9-A nrPDB 169 2e-42 5Z33-A nrPDB 167 6e-42 2I6L-A nrPDB 167 7e-42 3N9X-A nrPDB 164 4e-41 4E7W-A nrPDB 161 3e-40 3NIE-A nrPDB 157 6e-39 4QNY-A nrPDB 157 6e-39 3EB0-A nrPDB 157 7e-39 5AIR-A nrPDB 150 5e-37 3E3P-A nrPDB 148 3e-36 3PG1-A nrPDB 147 7e-36 5Y86-A nrPDB 146 1e-35 3E7O-A nrPDB 144 5e-35 5ZTN-A nrPDB 143 9e-35 3RP9-A nrPDB 141 3e-34 5AWM-A nrPDB 140 7e-34 1JNK-A nrPDB 137 4e-33 3FI2-A nrPDB 137 5e-33 2XS0-A nrPDB 137 8e-33 5YKS-A nrPDB 131 4e-31 4LFI-A nrPDB 129 2e-30 6O6Q-A nrPDB 126 1e-29 4MVF-A nrPDB 126 1e-29 6HMD-A nrPDB 125 3e-29 6EII-A nrPDB 122 2e-28 4IAN-A nrPDB 122 2e-28 4MD7-E nrPDB 121 3e-28 3MN3-A nrPDB 121 3e-28 3MA6-A nrPDB 120 9e-28 5JN2-A nrPDB 119 1e-27 2WO6-A nrPDB 117 4e-27 3LIJ-A nrPDB 117 6e-27 3DXN-A nrPDB 116 1e-26 3TAC-A nrPDB 116 1e-26 4D28-A nrPDB 116 1e-26 4RGJ-A nrPDB 116 1e-26 2PVN-A nrPDB 116 1e-26 5XZW-A nrPDB 116 1e-26 6QAU-A nrPDB 115 2e-26 6FD3-A nrPDB 115 2e-26 3HZT-A nrPDB 115 2e-26 2BDW-A nrPDB 115 3e-26 5FG8-A nrPDB 114 4e-26 3KK8-A nrPDB 114 4e-26 3DFA-A nrPDB 114 6e-26 3NCG-A nrPDB 113 8e-26 2UV2-A nrPDB 113 8e-26 4WNO-A nrPDB 112 1e-25 3EQC-A nrPDB 112 1e-25 5XVU-A nrPDB 112 2e-25 2JC6-A nrPDB 112 2e-25 4PDS-A nrPDB 112 3e-25 2WQN-A nrPDB 111 3e-25 6E2O-A nrPDB 110 5e-25 5KKR-C nrPDB 110 6e-25 4UZD-A nrPDB 110 7e-25 6FDY-U nrPDB 110 7e-25 3COM-A nrPDB 110 1e-24 3H4J-B nrPDB 109 2e-24 5ES1-A nrPDB 108 2e-24 4CZT-A nrPDB 108 3e-24 3Q53-A nrPDB 108 3e-24 4B8L-A nrPDB 108 4e-24 1KOA-A nrPDB 107 5e-24 2VN9-A nrPDB 107 5e-24 4EQM-A nrPDB 107 6e-24 3UTO-A nrPDB 107 6e-24 2X4F-A nrPDB 107 7e-24 5IG1-A nrPDB 107 9e-24 4FG9-A nrPDB 106 1e-23 4JXF-A nrPDB 106 2e-23 2QNJ-A nrPDB 105 3e-23 3BHH-A nrPDB 105 3e-23 2XNP-A nrPDB 105 4e-23 4LG4-A nrPDB 104 5e-23 5KZ7-A nrPDB 103 6e-23 3IS5-A nrPDB 103 8e-23 2VZ6-A nrPDB 103 9e-23 6AO5-A nrPDB 103 1e-22 4YZB-A nrPDB 103 1e-22 2Y7J-A nrPDB 103 1e-22 4JDH-A nrPDB 102 2e-22 6CQF-A nrPDB 102 2e-22 4AN9-A nrPDB 102 2e-22 4FIE-A nrPDB 102 2e-22 2Q0N-A nrPDB 102 2e-22 4XBR-A nrPDB 102 3e-22 4D2V-A nrPDB 102 3e-22 5U6Y-A nrPDB 102 3e-22 2HAK-A nrPDB 101 4e-22 5JZN-A nrPDB 101 4e-22 4YNZ-A nrPDB 101 4e-22 4CQG-A nrPDB 101 5e-22 2V7O-A nrPDB 101 5e-22 3D2K-A nrPDB 101 5e-22 3HKO-A nrPDB 100 5e-22 5EZV-A nrPDB 100 6e-22 6HXF-B nrPDB 100 6e-22 4CFF-A nrPDB 100 6e-22 6C9D-A nrPDB 100 7e-22 2BRG-A nrPDB 100 7e-22 5D7A-A nrPDB 100 7e-22 1S9I-A nrPDB 100 8e-22 4APC-A nrPDB 100 9e-22 4U41-A nrPDB 100 1e-21 2YZA-A nrPDB 99 2e-21 3SOA-A nrPDB 99 2e-21 4I6B-A nrPDB 99 3e-21 2JAM-A nrPDB 99 3e-21 4REW-A nrPDB 98 3e-21 6CTH-A nrPDB 98 4e-21 2PL0-A nrPDB 98 5e-21 4B6L-A nrPDB 98 5e-21 3Q5I-A nrPDB 97 6e-21 4RED-A nrPDB 97 7e-21 2F57-A nrPDB 97 7e-21 5J5T-A nrPDB 97 8e-21 4KS7-A nrPDB 97 8e-21 2XIK-A nrPDB 97 9e-21 4CFH-A nrPDB 97 1e-20 4QMW-A nrPDB 97 1e-20 2W4O-A nrPDB 96 2e-20 1KOB-A nrPDB 95 3e-20 1ZXE-A nrPDB 95 3e-20 6CMJ-A nrPDB 95 3e-20 2YCR-A nrPDB 95 4e-20 4PWN-A nrPDB 94 5e-20 5WAX-A nrPDB 94 6e-20 5UNP-A nrPDB 94 6e-20 2WTK-C nrPDB 94 6e-20 3F3Z-A nrPDB 94 9e-20 5O2B-A nrPDB 94 1e-19 5TUR-A nrPDB 94 1e-19 4C0T-A nrPDB 93 1e-19 5O2C-A nrPDB 93 1e-19 3I6U-A nrPDB 93 2e-19 5F9E-A nrPDB 93 2e-19 4TNB-A nrPDB 92 2e-19 4RC3-A nrPDB 92 2e-19 3BGP-A nrPDB 92 2e-19 1ZWS-A nrPDB 92 2e-19 4FZF-B nrPDB 92 2e-19 2A27-A nrPDB 92 3e-19 4WUA-A nrPDB 92 3e-19 5H2U-A nrPDB 92 3e-19 4RLP-A nrPDB 92 3e-19 4L42-A nrPDB 92 3e-19 2J90-A nrPDB 92 4e-19 5D9K-A nrPDB 92 4e-19 4AF3-A nrPDB 92 4e-19 3GUB-A nrPDB 92 4e-19 2YAB-A nrPDB 91 4e-19 2Z7Q-A nrPDB 91 7e-19 2JD5-A nrPDB 91 7e-19 6FYV-A nrPDB 91 8e-19 2GCD-A nrPDB 91 9e-19 5X8I-B nrPDB 91 9e-19 1U5R-A nrPDB 91 9e-19 5DBX-A nrPDB 90 9e-19 3RAW-A nrPDB 90 1e-18 3IO7-A nrPDB 89 2e-18 5UIU-A nrPDB 89 2e-18 2W1I-A nrPDB 89 2e-18 3UC3-A nrPDB 89 2e-18 2X7G-A nrPDB 89 2e-18 5YV8-A nrPDB 89 2e-18 4CSV-A nrPDB 89 2e-18 4M7I-A nrPDB 89 2e-18 3QA8-A nrPDB 89 2e-18 6DBN-A nrPDB 89 3e-18 4KIK-B nrPDB 89 3e-18 3ORZ-A nrPDB 89 3e-18 3HDN-A nrPDB 88 4e-18 2DQ7-X nrPDB 87 6e-18 3UDB-A nrPDB 87 1e-17 1U54-B nrPDB 87 1e-17 5MJB-A nrPDB 87 1e-17 3ZUT-A nrPDB 87 1e-17 4OLI-A nrPDB 87 1e-17 4HZS-A nrPDB 86 1e-17 6DBM-A nrPDB 86 1e-17 5FET-A nrPDB 86 2e-17 5AMN-A nrPDB 86 2e-17 5DYK-A nrPDB 86 2e-17 6F3F-A nrPDB 85 3e-17 4XEY-B nrPDB 85 3e-17 4NIF-A nrPDB 85 3e-17 3ORP-A nrPDB 85 3e-17 2H8H-A nrPDB 85 3e-17 3A8W-A nrPDB 85 4e-17 2JDO-A nrPDB 85 4e-17 6NPU-A nrPDB 85 5e-17 3NYO-A nrPDB 85 5e-17 2PSQ-A nrPDB 84 5e-17 6J5U-C nrPDB 84 6e-17 2XYN-A nrPDB 84 6e-17 3TXO-A nrPDB 84 6e-17 1TKI-A nrPDB 84 6e-17 3DB8-A nrPDB 84 7e-17 3A4O-X nrPDB 84 8e-17 4AT3-A nrPDB 84 8e-17 3MV5-A nrPDB 84 8e-17 5KCV-A nrPDB 84 1e-16 5TQX-A nrPDB 83 1e-16 5EG3-A nrPDB 83 1e-16 2FO0-A nrPDB 83 1e-16 3LM0-A nrPDB 83 2e-16 3DAK-A nrPDB 83 2e-16 4E20-A nrPDB 83 2e-16 3KN6-A nrPDB 83 2e-16 4RA4-A nrPDB 83 2e-16 6GVJ-A nrPDB 83 2e-16 3HMP-A nrPDB 82 3e-16 4TPT-A nrPDB 82 4e-16 5SYS-A nrPDB 81 5e-16 5AP3-A nrPDB 81 5e-16 5A46-A nrPDB 81 5e-16 4PDO-A nrPDB 81 5e-16 3UIU-A nrPDB 81 5e-16 5FM2-A nrPDB 81 6e-16 3GQL-A nrPDB 81 6e-16 2A1A-B nrPDB 81 6e-16 6FER-A nrPDB 81 6e-16 3TT0-A nrPDB 81 7e-16 4JG6-A nrPDB 81 7e-16 2OU7-A nrPDB 81 7e-16 5HVK-A nrPDB 80 9e-16 4J52-A nrPDB 80 9e-16 1FOT-A nrPDB 80 1e-15 2ZMD-A nrPDB 80 1e-15 6CCF-A nrPDB 80 1e-15 3QGY-A nrPDB 80 1e-15 2HK5-A nrPDB 80 2e-15 5L6P-A nrPDB 80 2e-15 3C1X-A nrPDB 80 2e-15 3DLS-A nrPDB 79 2e-15 4UYA-A nrPDB 79 2e-15 4YHJ-A nrPDB 79 2e-15 4UY9-A nrPDB 79 2e-15 5LOH-A nrPDB 79 2e-15 1PHK-A nrPDB 79 3e-15 1AD5-A nrPDB 79 3e-15 4XCU-A nrPDB 79 3e-15 3UIM-A nrPDB 78 4e-15 6BDL-A nrPDB 78 4e-15 5LPV-A nrPDB 78 5e-15 5LPZ-A nrPDB 77 7e-15 3VN9-A nrPDB 77 7e-15 3I81-A nrPDB 77 7e-15 3V5Q-A nrPDB 77 8e-15 3DTC-A nrPDB 77 9e-15 6E4F-A nrPDB 77 9e-15 3FME-A nrPDB 77 1e-14 4XI2-A nrPDB 77 1e-14 4E93-A nrPDB 77 1e-14 5HLW-A nrPDB 76 2e-14 4K33-A nrPDB 76 2e-14 5UUU-A nrPDB 76 2e-14 2I0E-A nrPDB 76 2e-14 3SXS-A nrPDB 76 2e-14 1U59-A nrPDB 76 2e-14 3PFQ-A nrPDB 75 2e-14 3PVW-A nrPDB 75 2e-14 4OTD-A nrPDB 75 3e-14 3ALO-A nrPDB 75 3e-14 4Y93-A nrPDB 75 3e-14 5N23-A nrPDB 75 3e-14 4XLV-A nrPDB 75 4e-14 4F9B-A nrPDB 75 4e-14 1LUF-A nrPDB 75 4e-14 1BYG-A nrPDB 75 4e-14 2OZO-A nrPDB 75 5e-14 4WB7-A nrPDB 74 6e-14 1K9A-A nrPDB 74 6e-14 4EBW-A nrPDB 74 8e-14 3C51-A nrPDB 74 8e-14 5O0Y-A nrPDB 74 8e-14 2J0K-A nrPDB 74 9e-14 2VWV-A nrPDB 74 9e-14 1JPA-A nrPDB 74 9e-14 5GNK-A nrPDB 74 1e-13 5TOS-A nrPDB 74 1e-13 4HVI-A nrPDB 74 1e-13 5X3F-B nrPDB 73 1e-13 5HI2-A nrPDB 73 2e-13 3LLT-A nrPDB 73 2e-13 3OMV-A nrPDB 73 2e-13 3PPZ-A nrPDB 73 2e-13 2HW6-A nrPDB 73 2e-13 6CKI-A nrPDB 73 2e-13 4IDT-A nrPDB 72 2e-13 3LZB-A nrPDB 72 2e-13 3DKO-A nrPDB 72 2e-13 5VD3-A nrPDB 72 2e-13 4G3E-A nrPDB 72 3e-13 3ZZW-A nrPDB 72 3e-13 2OGV-A nrPDB 72 4e-13 5KMM-A nrPDB 72 4e-13 5X5O-A nrPDB 72 4e-13 4X7Q-B nrPDB 72 4e-13 2PMN-X nrPDB 72 4e-13 4GS6-A nrPDB 71 5e-13 6HV0-A nrPDB 71 6e-13 4PL5-B nrPDB 71 6e-13 2RIO-A nrPDB 71 7e-13 2R2P-A nrPDB 70 8e-13 4R7H-A nrPDB 70 9e-13 4P5Q-A nrPDB 70 9e-13 5X02-A nrPDB 70 1e-12 4XUF-A nrPDB 70 1e-12 5U6B-A nrPDB 69 2e-12 4CRS-A nrPDB 69 2e-12 5B2L-A nrPDB 69 2e-12 2Y6O-A nrPDB 69 2e-12 6BSD-A nrPDB 69 3e-12 4H1J-A nrPDB 69 3e-12 4FR4-A nrPDB 69 3e-12 6FEX-A nrPDB 69 3e-12 5XD6-A nrPDB 69 3e-12 5WNO-A nrPDB 69 3e-12 3CJF-A nrPDB 68 4e-12 4NEU-A nrPDB 68 4e-12 1VZO-A nrPDB 68 5e-12 4LRM-A nrPDB 68 5e-12 3BBT-B nrPDB 67 7e-12 4JLC-A nrPDB 67 7e-12 4EUT-A nrPDB 67 9e-12 5VO2-A nrPDB 67 1e-11 5TE0-A nrPDB 67 1e-11 4FL3-A nrPDB 67 1e-11 3FXW-A nrPDB 67 1e-11 4C59-A nrPDB 67 1e-11 2QKW-B nrPDB 67 1e-11 5IKW-A nrPDB 67 1e-11 4EUU-A nrPDB 67 1e-11 5C26-A nrPDB 66 2e-11 5HIE-A nrPDB 66 2e-11 6NT9-A nrPDB 66 2e-11 3KUL-B nrPDB 66 2e-11 1NY3-A nrPDB 66 2e-11 2OZA-A nrPDB 66 2e-11 3AOX-A nrPDB 65 3e-11 5U6C-A nrPDB 65 3e-11 3KA0-A nrPDB 65 4e-11 3BEA-A nrPDB 65 4e-11 4X3F-A nrPDB 65 4e-11 4OW8-A nrPDB 65 5e-11 6B2Q-A nrPDB 65 5e-11 3KRL-A nrPDB 64 5e-11 2BUJ-A nrPDB 64 5e-11 6O8B-A nrPDB 64 7e-11 6ED6-A nrPDB 63 1e-10 3PP0-A nrPDB 63 1e-10 5GRN-A nrPDB 63 1e-10 3PLS-A nrPDB 63 2e-10 6BXI-A nrPDB 62 3e-10 6E9W-A nrPDB 62 3e-10 3QD2-B nrPDB 62 4e-10 2QLU-A nrPDB 60 8e-10 3QUP-A nrPDB 60 1e-09 3HNG-A nrPDB 60 1e-09 4Y83-A nrPDB 60 1e-09 3VHK-A nrPDB 60 2e-09 3ZBF-A nrPDB 59 2e-09 6GQK-A nrPDB 59 2e-09 4F0G-A nrPDB 59 3e-09 5WNL-A nrPDB 58 4e-09 4YFF-A nrPDB 58 6e-09 2WTK-B nrPDB 58 6e-09 1FVR-A nrPDB 57 8e-09 5CEK-A nrPDB 57 8e-09 3G0E-A nrPDB 57 9e-09 6DC0-A nrPDB 57 1e-08 4M66-A nrPDB 57 1e-08 3SOC-A nrPDB 57 1e-08 6BFN-A nrPDB 57 1e-08 5USZ-A nrPDB 57 1e-08 3Q4U-A nrPDB 57 1e-08 3LMG-A nrPDB 57 1e-08 4NFN-A nrPDB 56 2e-08 3MDY-A nrPDB 55 3e-08 4BTK-A nrPDB 55 3e-08 3G2F-A nrPDB 55 4e-08 2VD5-A nrPDB 54 6e-08 4L00-A nrPDB 54 1e-07 2H34-A nrPDB 54 1e-07 3TKU-A nrPDB 54 1e-07 5VDK-A nrPDB 53 2e-07 2Y4I-B nrPDB 52 3e-07 4AW2-A nrPDB 52 3e-07 4RT7-A nrPDB 50 1e-06 1PY5-A nrPDB 50 1e-06 5VC6-A nrPDB 49 2e-06 4JRN-A nrPDB 49 4e-06 5M07-A nrPDB 48 5e-06 4Y12-A nrPDB 48 5e-06 4M69-B nrPDB 47 8e-06 2PZI-A nrPDB 47 8e-06 4BTF-A nrPDB 47 9e-06 3SV0-A nrPDB 47 1e-05 4LQP-A nrPDB 47 1e-05 3M42-A nrPDB 47 1e-05 2C47-A nrPDB 47 1e-05 2CMW-A nrPDB 47 1e-05 5FQD-C nrPDB 46 2e-05 5L2Q-C nrPDB 46 2e-05 4L68-A nrPDB 45 4e-05 5AR8-A nrPDB 45 4e-05 4MWI-A nrPDB 45 5e-05 4IX6-A nrPDB 44 7e-05 2CHL-A nrPDB 44 8e-05 5E8V-A nrPDB 43 1e-04 3MY0-A nrPDB 43 2e-04 5X18-A nrPDB 43 2e-04 4WOV-A nrPDB 42 2e-04 5C01-A nrPDB 42 2e-04 4NT4-A nrPDB 42 4e-04 4XHL-A nrPDB 39 0.002 4TN6-A nrPDB 39 0.003 4XHH-A nrPDB 39 0.003 5CLR-A nrPDB 39 0.003 6J6I-B nrPDB 38 0.006 5UU1-A nrPDB 37 0.012 1CSN-A nrPDB 37 0.013 2RSV-A nrPDB 36 0.016 2LAV-A nrPDB 36 0.019 5UV4-A nrPDB 36 0.024 4BWP-A nrPDB 34 0.062 4CYJ-A nrPDB 34 0.077 5X1R-A nrPDB 34 0.077 5J0A-A nrPDB 34 0.093 4O1O-A nrPDB 33 0.16 3MZV-A nrPDB 33 0.18 4AZV-A nrPDB 32 0.39 6G4J-A nrPDB 32 0.43 4AZW-A nrPDB 32 0.46 5OAT-A nrPDB 31 0.54 3OYR-A nrPDB 31 0.55 4CI6-B nrPDB 31 0.57 2JII-A nrPDB 30 1.1 4OAU-C nrPDB 29 2.3 4JXN-A nrPDB 29 2.9 6EWX-A nrPDB 28 5.7 2X8B-A nrPDB 28 5.9 3ENH-A nrPDB 28 6.6 5VE6-A nrPDB 28 6.7 5DMZ-A nrPDB 27 9.6 >4KRC-A nrPDB Length = 317 Score = 635 bits (1638), Expect = 0.0, Method: Compositional matrix adjust. Identities = 305/305 (100%), Positives = 305/305 (100%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL Sbjct: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG Sbjct: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL Sbjct: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP Sbjct: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY Sbjct: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 Query: 301 YHHAS 305 YHHAS Sbjct: 301 YHHAS 305 >2BPM-A nrPDB Length = 309 Score = 342 bits (876), Expect = 2e-94, Method: Compositional matrix adjust. Identities = 165/294 (56%), Positives = 217/294 (73%), Gaps = 10/294 (3%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHENI 65 F+++EK+G GTY VYK NK TG VALK+++LD+E EG PSTAIREISL+KEL H NI Sbjct: 9 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 68 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 V+L DVIHTENKL LVFEF+ DLKK+MD+ + G+ L L+K + +QLLQGLAFCH Sbjct: 69 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALT----GIPLPLIKSYLFQLLQGLAFCH 124 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 +++LHRDLKPQNLLIN G +KL DFGLARAFG+PV T++ EVVTLWYRAP++L+G + Sbjct: 125 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 184 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 YST++DIWS GCI AEM+T + LFPG ++ +QL IF +GTP+E +WP VT +P Y P+ Sbjct: 185 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 244 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + +D +V+ PLD + L +L +P+ R+SAK AL HP+F + Sbjct: 245 FPKWARQDFSKVV-----PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 293 >4AU8-A nrPDB Length = 296 Score = 333 bits (855), Expect = 4e-92, Method: Compositional matrix adjust. Identities = 168/299 (56%), Positives = 216/299 (72%), Gaps = 12/299 (4%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKH 62 S ++++LEK+G GTY TV+K N+ T VALK V+LD + EG PS+A+REI L+KELKH Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 64 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 +NIVRL+DV+H++ KLTLVFEF D DLKKY DS G+ L+ +VK F +QLL+GL Sbjct: 65 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GD----LDPEIVKSFLFQLLKGLG 119 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 FCH +LHRDLKPQNLLIN+ G+LKL DFGLARAFGIPV +S+EVVTLWYR PDVL G Sbjct: 120 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 179 Query: 183 SRTYSTSIDIWSCGCILAEMI-TGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 ++ YSTSID+WS GCI AE+ G+PLFPG + ++QLK IF ++GTP E WPS+TKLP Sbjct: 180 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 239 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 Y P L V+ L+ D L LL+ NP R+SA++AL HP+F+++ Sbjct: 240 YKPYPMYPATTSLVNVV-----PKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 293 >1V0B-A nrPDB Length = 288 Score = 332 bits (852), Expect = 9e-92, Method: Compositional matrix adjust. Identities = 166/295 (56%), Positives = 210/295 (71%), Gaps = 12/295 (4%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHEN 64 ++ LEK+G GTY VYK N G ALK+++L+ E EG PST IREIS++KELKH N Sbjct: 3 KYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSN 61 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 IV+LYDVIHT+ +L LVFE +D DLKK +D GLE K F QLL G+A+C Sbjct: 62 IVKLYDVIHTKKRLVLVFEHLDQDLKKLLDV-----CEGGLESVTAKSFLLQLLNGIAYC 116 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 H+ ++LHRDLKPQNLLIN+ G+LK+ DFGLARAFGIPV ++ EVVTLWYRAPDVLMGS+ Sbjct: 117 HDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSK 176 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 YST+IDIWS GCI AEM+ G PLFPG ++ +QL IF I+GTPN WP+VT+LPKY+P Sbjct: 177 KYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDP 236 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 N P L+ LD + +D L +L+L+P+ R++AKQAL H +F E Sbjct: 237 NFTVYEPLPWESFLK-----GLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >3NIZ-A nrPDB Length = 311 Score = 322 bits (825), Expect = 1e-88, Method: Compositional matrix adjust. Identities = 164/302 (54%), Positives = 211/302 (69%), Gaps = 25/302 (8%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHEN 64 ++++LEK+G GTY VYK + G VALK ++LD+E EG PSTAIREISL+KEL H N Sbjct: 22 KYQKLEKVGEGTYGVVYKA-KDSQGRIVALKRIRLDAEDEGIPSTAIREISLLKELHHPN 80 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 IV L DVIH+E LTLVFEFM+ DLKK +D G L+ + +K + +QLL+G+A C Sbjct: 81 IVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKTG-----LQDSQIKIYLYQLLRGVAHC 135 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 H+++ILHRDLKPQNLLIN G LKL DFGLARAFGIPV +++ EVVTLWYRAPDVLMGS+ Sbjct: 136 HQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSK 195 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 YSTS+DIWS GCI AEMITGKPLFPG D++QL IF I+GTPN WP V +LP + Sbjct: 196 KYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWK- 254 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNL-------MDFLHGLLQLNPDMRLSAKQALHHPWF 297 ++ Q K+P + +D L +L +P+ R+SA+ A++HP+F Sbjct: 255 ----------QRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYF 304 Query: 298 AE 299 + Sbjct: 305 KD 306 >5G6V-A nrPDB Length = 324 Score = 319 bits (817), Expect = 1e-87, Method: Compositional matrix adjust. Identities = 162/294 (55%), Positives = 204/294 (69%), Gaps = 15/294 (5%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 + +L+KLG GTYATVYKG +K T VALKE++L+ EEG P TAIRE+SL+K+LKH NIV Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIV 63 Query: 67 RLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 L+D+IHTE LTLVFE++D DLK+Y+D GN + ++ VK F +QLL+GLA+CH Sbjct: 64 TLHDIIHTEKSLTLVFEYLDKDLKQYLDD--CGNI---INMHNVKLFLFQLLRGLAYCHR 118 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 K+LHRDLKPQNLLIN+RG+LKL DFGLARA IP T+ +EVVTLWYR PD+L+GS Y Sbjct: 119 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDY 178 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV---TKLPKYN 243 ST ID+W GCI EM TG+PLFPG+ EEQL IF I+GTP E WP + + YN Sbjct: 179 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 238 Query: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 P+ + L H LD + D L LLQ R+SA+ A+ HP+F Sbjct: 239 ------YPKYRAEALLSHAPR-LDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >6GU6-A nrPDB Length = 302 Score = 306 bits (784), Expect = 6e-84, Method: Compositional matrix adjust. Identities = 154/300 (51%), Positives = 207/300 (69%), Gaps = 9/300 (3%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE-GTPSTAIREISLMKE 59 + S + ++EK+G GTY VYKG +KTTG VA+K+++L+SEE G PSTAIREISL+KE Sbjct: 3 LGSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKE 62 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 L+H NIV L DV+ +++L L+FEF+ DLKKY+DS G ++ +LVK + +Q+LQ Sbjct: 63 LRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQY---MDSSLVKSYLYQILQ 119 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 G+ FCH ++LHRDLKPQNLLI+ +G +KL DFGLARAFGIP+ ++ EVVTLWYR+P+V Sbjct: 120 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 179 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 L+GS YST +DIWS G I AE+ T KPLF G ++ +QL IF +GTPN +WP V L Sbjct: 180 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 239 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 Y + P L H K LD N +D L +L +P R+S K AL+HP+F + Sbjct: 240 QDYKNTFPKWKPGSLAS----HVKN-LDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 294 >3GC0-A nrPDB Length = 329 Score = 283 bits (725), Expect = 5e-77, Method: Compositional matrix adjust. Identities = 138/303 (45%), Positives = 202/303 (66%), Gaps = 16/303 (5%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD-SEEGTPSTAIREISLMKEL 60 +S +++++ KLG GTY VYK ++ T VA+K ++L+ EEG P TAIRE+SL+KEL Sbjct: 31 TSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKEL 90 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +H NI+ L VIH ++L L+FE+ +NDLKKYMD + + ++K F +QL+ G Sbjct: 91 QHRNIIELKSVIHHNHRLHLIFEYAENDLKKYMDKNP------DVSMRVIKSFLYQLING 144 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQ-----LKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 + FCH + LHRDLKPQNLL++ LK+GDFGLARAFGIP+ F+ E++TLWYR Sbjct: 145 VNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYR 204 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 P++L+GSR YSTS+DIWS CI AEM+ PLFPG ++ +QL IF+++G P+++ WP Sbjct: 205 PPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPG 264 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 VT LP + + + + L++VL + L +L+++P R+SAK AL HP Sbjct: 265 VTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLT----AMLEMDPVKRISAKNALEHP 320 Query: 296 WFA 298 +F+ Sbjct: 321 YFS 323 >1UA2-A nrPDB Length = 346 Score = 236 bits (601), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 120/301 (39%), Positives = 185/301 (61%), Gaps = 15/301 (4%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKL----DSEEGTPSTAIREISLM 57 S + ++++L+ LG G +ATVYK +K T VA+K++KL ++++G TA+REI L+ Sbjct: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 Query: 58 KELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 +EL H NI+ L D ++ ++LVF+FM+ DL+ + ++ TP + +K + Sbjct: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTP-----SHIKAYMLMT 121 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 LQGL + H++ ILHRDLKP NLL+++ G LKL DFGLA++FG P ++ +VVT WYRAP Sbjct: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 ++L G+R Y +D+W+ GCILAE++ P PG +D +QL IF+ +GTP E WP + Sbjct: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 LP Y + P L + + L+D + GL NP R++A QAL +F Sbjct: 242 SLPDYV-TFKSFPGIPLHHIFSAAGDD-----LLDLIQGLFLFNPCARITATQALKMKYF 295 Query: 298 A 298 + Sbjct: 296 S 296 >1G3N-A nrPDB Length = 326 Score = 227 bits (578), Expect = 5e-60, Method: Compositional matrix adjust. Identities = 127/315 (40%), Positives = 183/315 (58%), Gaps = 39/315 (12%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLN-KTTGVYVALKEVKLDS-EEGTPSTAIREISLMKEL 60 + Q++ + ++G G Y V+K + K G +VALK V++ + EEG P + IRE+++++ L Sbjct: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 Query: 61 K---HENIVRLYDVIHT-----ENKLTLVFEFMDNDLKKYMDSRTVGNTPR-GLELNLVK 111 + H N+VRL+DV E KLTLVFE +D DL Y+D P G+ +K Sbjct: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLD-----KVPEPGVPTETIK 123 Query: 112 YFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVT 171 +QLL+GL F H ++++HRDLKPQN+L+ GQ+KL DFGLAR + + +S VVT Sbjct: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVT 182 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 LWYRAP+VL+ S +Y+T +D+WS GCI AEM KPLF G++D +QL I D++G P E Sbjct: 183 LWYRAPEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 Query: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLM-------DFLHGLLQLNPDM 284 WP LP RQ + +P++ + D L L NP Sbjct: 242 DWPRDVALP--------------RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAK 287 Query: 285 RLSAKQALHHPWFAE 299 R+SA AL HP+F + Sbjct: 288 RISAYSALSHPYFQD 302 >5EFQ-A nrPDB Length = 347 Score = 225 bits (573), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 124/306 (40%), Positives = 183/306 (59%), Gaps = 31/306 (10%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHE 63 +F + +G GTY VYK +K TG VALK+V+LD+E EG P TAIREI ++++L H+ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 64 NIVRLYDVI----------HTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYF 113 +I+ + +++ + LVFE+MD+DL ++S V N +K F Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVH-----FNENHIKSF 125 Query: 114 QWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT-FSSEVVTL 172 QL++GL +CH+ LHRD+K N+L+N RGQ+KL DFGLAR + + ++++V+TL Sbjct: 126 MRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITL 185 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESL 232 WYR P++L+G Y+ +ID+WSCGCIL E+ T KP+F + QL+LI I G+P ++ Sbjct: 186 WYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAV 245 Query: 233 WPSVTKLPKYN---PNIQQRPPRDLRQ--VLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 WP V KLP +N P Q R R LR+ V P +D +L L+P R + Sbjct: 246 WPDVIKLPYFNTMKPKKQYR--RKLREEFVFIP-------AAALDLFDYMLALDPSKRCT 296 Query: 288 AKQALH 293 A+QAL Sbjct: 297 AEQALQ 302 >2W96-B nrPDB Length = 306 Score = 224 bits (572), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 128/304 (42%), Positives = 183/304 (60%), Gaps = 22/304 (7%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKL-DSEEGTPSTAIREISLMKELK 61 ++S+++ + ++G G Y TVYK + +G +VALK V++ + EEG P + +RE++L++ L+ Sbjct: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLE 61 Query: 62 ---HENIVRLYDVIHT-----ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYF 113 H N+VRL DV T E K+TLVFE +D DL+ Y+D P GL +K Sbjct: 62 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDK----APPPGLPAETIKDL 117 Query: 114 QWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW 173 Q L+GL F H N I+HRDLKP+N+L+ G +KL DFGLAR + + VVTLW Sbjct: 118 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALDPVVVTLW 176 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 YRAP+VL+ S TY+T +D+WS GCI AEM KPLF G ++ +QL IFD++G P E W Sbjct: 177 YRAPEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 235 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 P LP+ R PR ++ V+ P +E + L +L NP R+SA +AL Sbjct: 236 PRDVSLPRG--AFPPRGPRPVQSVV-PEMEE----SGAQLLLEMLTFNPHKRISAFRALQ 288 Query: 294 HPWF 297 H + Sbjct: 289 HSYL 292 >4NST-A nrPDB Length = 351 Score = 216 bits (551), Expect = 8e-57, Method: Compositional matrix adjust. Identities = 116/300 (38%), Positives = 181/300 (60%), Gaps = 21/300 (7%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHEN 64 +F + +G GTY VYK +K TG VALK+V+LD+E EG P TAIREI ++++L H + Sbjct: 14 KFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRS 73 Query: 65 IVRLYDVI----------HTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQ 114 +V + +++ + LVFE+MD+DL ++S V + + +K F Sbjct: 74 VVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSE-----DHIKSFM 128 Query: 115 WQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT-FSSEVVTLW 173 QL++GL +CH+ LHRD+K N+L+N GQ+KL DFGLAR + + ++++V+TLW Sbjct: 129 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW 188 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 YR P++L+G Y+ +ID+WSCGCIL E+ T KP+F + QL+LI + G+P ++W Sbjct: 189 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 248 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 P V KLP +N +P + R+ L+ + +D L +L L+P R +A+Q L Sbjct: 249 PDVIKLPYFN---TMKPKKQYRRRLREEFSF-IPSAALDLLDHMLTLDPSKRCTAEQTLQ 304 >3MIA-A nrPDB Length = 351 Score = 211 bits (538), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 117/307 (38%), Positives = 182/307 (59%), Gaps = 22/307 (7%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHE 63 S++++L K+G GT+ V+K ++ TG VALK+V +++E EG P TA+REI +++ LKHE Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Query: 64 NIVRLYDVIHTE--------NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 N+V L ++ T+ + LVF+F ++DL + + V T L+ +K Sbjct: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT-----LSEIKRVMQ 131 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT----FSSEVVT 171 LL GL + H NKILHRD+K N+LI + G LKL DFGLARAF + N+ +++ VVT Sbjct: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 LWYR P++L+G R Y ID+W GCI+AEM T P+ G ++ QL LI + G+ Sbjct: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 Query: 232 LWPSVTKLPKYNP-NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 +WP+V Y + + R ++ L+ + ++P +D + LL L+P R+ + Sbjct: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPY---ALDLIDKLLVLDPAQRIDSDD 308 Query: 291 ALHHPWF 297 AL+H +F Sbjct: 309 ALNHDFF 315 >4AGU-A nrPDB Length = 311 Score = 204 bits (519), Expect = 4e-53, Method: Compositional matrix adjust. Identities = 111/300 (37%), Positives = 175/300 (58%), Gaps = 21/300 (7%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEG--TPSTAIREISLMKELKH 62 +++++ K+G G+Y V+K N+ TG VA+K+ L+SE+ A+REI ++K+LKH Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKF-LESEDDPVIKKIALREIRMLKQLKH 61 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 N+V L +V + +L LVFE+ D+ + +D RG+ +LVK WQ LQ + Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQ-----RGVPEHLVKSITWQTLQAVN 116 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 FCH++ +HRD+KP+N+LI K +KL DFG AR P + + EV T WYR+P++L+G Sbjct: 117 FCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVG 176 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP---SVTKL 239 Y +D+W+ GC+ AE+++G PL+PG +D +QL LI +G L P V Sbjct: 177 DTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLG----DLIPRHQQVFST 232 Query: 240 PKYNPNIQQRPPRDLR--QVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 +Y ++ P D+ ++ P+ P G L G L ++P RL+ +Q LHHP+F Sbjct: 233 NQYFSGVKIPDPEDMEPLELKFPNISYPALG----LLKGCLHMDPTERLTCEQLLHHPYF 288 >4BBM-A nrPDB Length = 331 Score = 201 bits (511), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 107/302 (35%), Positives = 172/302 (56%), Gaps = 17/302 (5%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKE-VKLDSEEGTPSTAIREISLMKE 59 S +++ L +G G+Y V K NK TG VA+K+ ++ D ++ A+REI L+K+ Sbjct: 21 FQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQ 80 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 L+HEN+V L +V + + LVFEF+D+ + +D + P GL+ +V+ + +Q++ Sbjct: 81 LRHENLVNLLEVCKKKKRWYLVFEFVDHTI---LDDLEL--FPNGLDYQVVQKYLFQIIN 135 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 G+ FCH + I+HRD+KP+N+L+++ G +KL DFG AR P + EV T WYRAP++ Sbjct: 136 GIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPEL 195 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 L+G Y ++D+W+ GC++ EM G+PLFPG +D +QL I +G K Sbjct: 196 LVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKN 255 Query: 240 PKYN----PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 P + P I++R P + R P E ++D L ++PD R + LHH Sbjct: 256 PVFAGVRLPEIKEREPLERR---YPKLSEV----VIDLAKKCLHIDPDKRPFCAELLHHD 308 Query: 296 WF 297 +F Sbjct: 309 FF 310 >3ZDU-A nrPDB Length = 325 Score = 194 bits (493), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 106/300 (35%), Positives = 170/300 (56%), Gaps = 18/300 (6%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 S ++ L K+G G+Y TV K +K TG VA+K E+ A+REI +K+ H Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHH 60 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 EN+V L +V + K+ LVFEF+D+ + +D + + GLE ++ + +Q+L+ + Sbjct: 61 ENLVNLIEVFRQKKKIHLVFEFIDHTV---LDE--LQHYCHGLESKRLRKYLFQILRAID 115 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 + H N I+HRD+KP+N+L+++ G KL DFG AR P + + EV T WYRAP++++ Sbjct: 116 YLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLK 175 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 +Y +DIW+ GC++ EM TG P P ++D + L I +G + L +K P + Sbjct: 176 DTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIF 235 Query: 243 N----PNIQQRPPRDLRQVLQPHTKEP-LDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 P +Q P++ R+ K P L+G L D +H LQ++P R+S+ LHH +F Sbjct: 236 AGVVLPQVQH--PKNARK------KYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 287 >4ZSG-A nrPDB Length = 347 Score = 188 bits (478), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 109/309 (35%), Positives = 173/309 (55%), Gaps = 24/309 (7%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKELKHE 63 +++ +E +GNG Y V + TG VA+K++ D T +RE+ ++K KH+ Sbjct: 8 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRT-LRELKILKHFKHD 66 Query: 64 NIVRLYDVIHTE------NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 NI+ + D++ + +V + M++DL + + S + L L V+YF +QL Sbjct: 67 NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSS------QPLTLEHVRYFLYQL 120 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGI-PV--NTFSSE-VVTLW 173 L+GL + H +++HRDLKP NLL+N+ +LK+GDFG+AR P F +E V T W Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 YRAP++++ Y+ +ID+WS GCI EM+ + LFPG N QL+LI ++GTP+ ++ Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 240 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEP-LDGNLMDFLHGLLQLNPDMRLSAKQAL 292 +V + IQ PP RQ + T P D + L +L+ P R+SA AL Sbjct: 241 QAVGA-ERVRAYIQSLPP---RQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAAL 296 Query: 293 HHPWFAEYY 301 HP+ A+Y+ Sbjct: 297 RHPFLAKYH 305 >4IC8-A nrPDB Length = 442 Score = 187 bits (475), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 109/309 (35%), Positives = 173/309 (55%), Gaps = 24/309 (7%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKELKHE 63 +++ +E +GNG Y V + TG VA+K++ D T +RE+ ++K KH+ Sbjct: 56 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRT-LRELKILKHFKHD 114 Query: 64 NIVRLYDVIHTE------NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 NI+ + D++ + +V + M++DL + + S + L L V+YF +QL Sbjct: 115 NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSS------QPLTLEHVRYFLYQL 168 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGI-PV--NTFSSE-VVTLW 173 L+GL + H +++HRDLKP NLL+N+ +LK+GDFG+AR P F +E V T W Sbjct: 169 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 228 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 YRAP++++ Y+ +ID+WS GCI EM+ + LFPG N QL+LI ++GTP+ ++ Sbjct: 229 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 288 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEP-LDGNLMDFLHGLLQLNPDMRLSAKQAL 292 +V + IQ PP RQ + T P D + L +L+ P R+SA AL Sbjct: 289 QAVGA-ERVRAYIQSLPP---RQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAAL 344 Query: 293 HHPWFAEYY 301 HP+ A+Y+ Sbjct: 345 RHPFLAKYH 353 >4QTB-A nrPDB Length = 380 Score = 184 bits (466), Expect = 5e-47, Method: Compositional matrix adjust. Identities = 100/305 (32%), Positives = 164/305 (53%), Gaps = 20/305 (6%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 ++ QL+ +G G Y V + VA+K++ + +REI ++ +HEN+ Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 101 Query: 66 VRLYDVIHTEN-----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 + + D++ + +V + M+ DL K + S+ + N + + YF +Q+L+G Sbjct: 102 IGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSN-------DHICYFLYQILRG 154 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIP----VNTFSSEVVTLWYRA 176 L + H +LHRDLKP NLLIN LK+ DFGLAR P + V T WYRA Sbjct: 155 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRA 213 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P++++ S+ Y+ SIDIWS GCILAEM++ +P+FPG + +QL I I+G+P++ + Sbjct: 214 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 273 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 + N +Q P + +V D +D L +L NP+ R++ ++AL HP+ Sbjct: 274 INMKARN-YLQSLPSKT--KVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPY 330 Query: 297 FAEYY 301 +YY Sbjct: 331 LEQYY 335 >4BGQ-A nrPDB Length = 304 Score = 182 bits (463), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 112/299 (37%), Positives = 172/299 (57%), Gaps = 18/299 (6%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEG--TPSTAIREISLMKELKH 62 ++F+ L +G G Y V K +K T VA+K+ K DSEE T +RE+ +++ LK Sbjct: 12 NKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFK-DSEENEEVKETTLRELKMLRTLKQ 70 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 ENIV L + KL LVFE+++ ++ + ++ P G+ VK + +QL++ + Sbjct: 71 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEE-----MPNGVPPEKVKSYIYQLIKAIH 125 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT-FSSEVVTLWYRAPDVLM 181 +CH+N I+HRD+KP+NLLI+ LKL DFG AR N + EV T WYR+P++L+ Sbjct: 126 WCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLL 185 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMG-TPNESLWPSVTKLP 240 G+ Y S+D+WS GCIL E+ G+PLFPG ++ +QL I ++G P+E + KL Sbjct: 186 GA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQM-----KLF 239 Query: 241 KYNPNIQ--QRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 NP + P + Q L+ L+ L+D + LL+L+P R +Q L+HP F Sbjct: 240 YSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 298 >2F9G-A nrPDB Length = 353 Score = 182 bits (461), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 105/318 (33%), Positives = 170/318 (53%), Gaps = 30/318 (9%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 +SS Q K L LG G Y V +K TG VA+K+++ + +REI ++K Sbjct: 9 ISSDFQLKSL--LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 Query: 61 KHENIVRLYDVIHTE-----NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 KHENI+ ++++ + N++ ++ E M DL + + ++ + + + ++YF + Sbjct: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSD-------DHIQYFIY 119 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPV----------NTF 165 Q L+ + H + ++HRDLKP NLLIN LK+ DFGLAR + Sbjct: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 Query: 166 SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIM 225 + V T WYRAP+V++ S YS ++D+WSCGCILAE+ +P+FPG + QL LIF I+ Sbjct: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 Query: 226 GTPNESLWPSVTKLPKYNPNIQQRP--PRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPD 283 GTP+ + P+ I+ P P + + P ++ +D L +L +P Sbjct: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR----VNPKGIDLLQRMLVFDPA 295 Query: 284 MRLSAKQALHHPWFAEYY 301 R++AK+AL HP+ Y+ Sbjct: 296 KRITAKEALEHPYLQTYH 313 >4EWQ-A nrPDB Length = 383 Score = 181 bits (458), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 105/301 (34%), Positives = 170/301 (56%), Gaps = 16/301 (5%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST-AIREISLMKELKHEN 64 +++ L +G+G Y +V + TG+ VA+K++ + + RE+ L+K +KHEN Sbjct: 46 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 105 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLEL--NLVKYFQWQLLQGLA 122 ++ L DV L EF D L ++ + N + +L + V++ +Q+L+GL Sbjct: 106 VIGLLDVFTPARSLE---EFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLK 162 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 + H I+HRDLKP NL +N+ +LK+ DFGLAR + + V T WYRAP++++ Sbjct: 163 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD---DEMTGYVATRWYRAPEIMLN 219 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT--KLP 240 Y+ ++DIWS GCI+AE++TG+ LFPGT+ +QLKLI ++GTP L ++ Sbjct: 220 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 279 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 Y ++ Q P + V PL +D L +L L+ D R++A QAL H +FA+Y Sbjct: 280 NYIQSLTQMPKMNFANVFI--GANPL---AVDLLEKMLVLDSDKRITAAQALAHAYFAQY 334 Query: 301 Y 301 + Sbjct: 335 H 335 >4CRL-A nrPDB Length = 406 Score = 181 bits (458), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 108/321 (33%), Positives = 177/321 (55%), Gaps = 42/321 (13%) Query: 12 KLGNGTYATVYKGLNKTTGVYV--ALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 K+G GTY VYK K ALK+++ G +A REI+L++ELKH N++ L Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQIE---GTGISMSACREIALLRELKHPNVISLQ 85 Query: 70 DVI--HTENKLTLVFEFMDNDL---KKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 V H + K+ L+F++ ++DL K+ + P L +VK +Q+L G+ + Sbjct: 86 KVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYL 145 Query: 125 HENKILHRDLKPQNLLI----NKRGQLKLGDFGLARAFGIPVNTFSS---EVVTLWYRAP 177 H N +LHRDLKP N+L+ +RG++K+ D G AR F P+ + VVT WYRAP Sbjct: 146 HANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAP 205 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDE---------EQLKLIFDIMGTP 228 ++L+G+R Y+ +IDIW+ GCI AE++T +P+F ++ +QL IF++MG P Sbjct: 206 ELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFP 265 Query: 229 NESLWPSVTKLPKYNPNIQQRPPRDLR----------QVLQPHTKEPLDGNLMDFLHGLL 278 + W + K+P+++ + +D R + ++ H +P D L LL Sbjct: 266 ADKDWEDIKKMPEHSTLM-----KDFRRNTYTNCSLIKYMEKHKVKP-DSKAFHLLQKLL 319 Query: 279 QLNPDMRLSAKQALHHPWFAE 299 ++P R++++QA+ P+F E Sbjct: 320 TMDPIKRITSEQAMQDPYFLE 340 >5NGU-A nrPDB Length = 381 Score = 179 bits (453), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 102/309 (33%), Positives = 161/309 (52%), Gaps = 28/309 (9%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 ++ L +G G Y V + V VA+K++ + +REI ++ +HENI Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENI 102 Query: 66 VRLYDVIHTEN-----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 + + D+I + +V + M+ DL K + ++ + N + + YF +Q+L+G Sbjct: 103 IGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSN-------DHICYFLYQILRG 155 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIP---VNTFSSEVVTLWYRAP 177 L + H +LHRDLKP NLL+N LK+ DFGLAR + V T WYRAP Sbjct: 156 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 215 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 ++++ S+ Y+ SIDIWS GCILAEM++ +P+FPG + +QL I I+G+P++ + Sbjct: 216 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 275 Query: 238 KLPKYN-----PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 L N P+ + P L P+ D +D L +L NP R+ +QAL Sbjct: 276 NLKARNYLLSLPHKNKVP----WNRLFPNA----DSKALDLLDKMLTFNPHKRIEVEQAL 327 Query: 293 HHPWFAEYY 301 HP+ +YY Sbjct: 328 AHPYLEQYY 336 >3OZ6-A nrPDB Length = 388 Score = 178 bits (452), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 112/336 (33%), Positives = 180/336 (53%), Gaps = 46/336 (13%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST-AIREISLMKELK-HE 63 +++ ++KLG G Y V+K +++ TG VA+K++ + T + REI ++ EL HE Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHE 69 Query: 64 NIVRLYDVIHTENK--LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NIV L +V+ +N + LVF++M+ DL + + LE +Y +QL++ + Sbjct: 70 NIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRANI-------LEPVHKQYVVYQLIKVI 122 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF--------GIPVNT--------- 164 + H +LHRD+KP N+L+N +K+ DFGL+R+F IP++ Sbjct: 123 KYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDD 182 Query: 165 ----FSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKL 220 + V T WYRAP++L+GS Y+ ID+WS GCIL E++ GKP+FPG++ QL+ Sbjct: 183 DQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLER 242 Query: 221 IFDIMGTPN----ESLWPSVTKLP----KYNPNIQQRPPRDL-----RQVLQPHTKEPLD 267 I ++ P+ ES+ K K I+Q RD+ +L+ + K + Sbjct: 243 IIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCN 302 Query: 268 GNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHH 303 +D L LLQ NP+ R+SA AL HP F +H+ Sbjct: 303 EEALDLLDKLLQFNPNKRISANDALKHP-FVSIFHN 337 >6DTL-A nrPDB Length = 364 Score = 178 bits (451), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 106/294 (36%), Positives = 163/294 (55%), Gaps = 23/294 (7%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVK--LDSEEGTPSTAIREISLMKELKHENIVRLYD 70 +G G Y V +N T VA+K++ D++ T +REI L++ + HENIV + D Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRT-LREIKLLRHMDHENIVAIRD 96 Query: 71 VI-----HTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 +I + N + + +E MD DL + + S + L +YF +Q+L+GL + H Sbjct: 97 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSN------QALSEEHCQYFLYQILRGLKYIH 150 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE-VVTLWYRAPDVLMGSR 184 +LHRDLKP NLL+N LK+ DFGLAR + F +E VVT WYRAP++L+ S Sbjct: 151 SANVLHRDLKPSNLLLNANCDLKICDFGLARVTS--ESDFMTEYVVTRWYRAPELLLNSS 208 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 Y+ +ID+WS GCI E++ KPLFPG + QL+L+ +++GTP+E + + K Sbjct: 209 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKR-- 266 Query: 245 NIQQRPPRDLRQVLQPH-TKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 I+Q PP + + T PL +D + +L +P R++ AL HP+ Sbjct: 267 YIRQLPPYPRQSITDKFPTVHPL---AIDLIEKMLTFDPRRRITVLDALAHPYL 317 >1CM8-A nrPDB Length = 367 Score = 178 bits (451), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 106/300 (35%), Positives = 164/300 (54%), Gaps = 24/300 (8%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHENI 65 ++ L+ +G+G Y V ++ TG VA+K++ + E A RE+ L+K ++HEN+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 66 VRLYDVIHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 + L DV + L LV FM DL K M +G + +++ +Q+L+ Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE-------DRIQFLVYQMLK 139 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 GL + H I+HRDLKP NL +N+ +LK+ DFGLAR + + VVT WYRAP+V Sbjct: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEV 196 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT-- 237 ++ Y+ ++DIWS GCI+AEMITGK LF G++ +QLK I + GTP + Sbjct: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + Y + + +D +L PL NL L +L L+ + R++A +AL HP+F Sbjct: 257 EAKNYMKGLPELEKKDFASILT--NASPLAVNL---LEKMLVLDAEQRVTAGEALAHPYF 311 >4O2Z-A nrPDB Length = 377 Score = 176 bits (447), Expect = 9e-45, Method: Compositional matrix adjust. Identities = 106/306 (34%), Positives = 166/306 (54%), Gaps = 27/306 (8%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVK---LDSEEGTPSTAIREISLMKELK 61 S++ L+ LG G Y L+ TG V++K+ + D E+G +REI +M+ Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDG--KRVLREIDMMRFFH 102 Query: 62 HENIVRLYDVI-------HTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQ 114 HEN++ + +++ H+ + +V MD D+ + SR V LE + ++YF Sbjct: 103 HENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQV------LEESHMQYFV 156 Query: 115 WQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 +Q+L+GL + H + HRDLKP NL+ N +LK+ DFGL+R+ +P + + V+T WY Sbjct: 157 YQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWY 216 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 R P++L+ + YST++DIWS GCI AEM KP+FPG N +QL++I +G P S+ Sbjct: 217 RPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVE 276 Query: 235 SVTKLPKYN--PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 L K N P+ P+ L P +G +DFL + L+P R +A L Sbjct: 277 HREALEKLNELPDGSLNIPK-----LVPGLAGNTEG--IDFLSKMWTLDPSKRPTAADML 329 Query: 293 HHPWFA 298 HP+ A Sbjct: 330 AHPYLA 335 >4MYG-A nrPDB Length = 372 Score = 176 bits (446), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 108/302 (35%), Positives = 164/302 (54%), Gaps = 35/302 (11%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLD-SEEGTPSTAIREISLMKELKHENIVRLYDV 71 +G+G Y +V ++K +G VA+K++ E A RE+ L+K ++HEN++ L DV Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 72 IHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELN--LVKYFQWQLLQGLAF 123 + L LV FM DL+K M G+E + ++Y +Q+L+GL + Sbjct: 111 FTPASSLRNFYDFYLVMPFMQTDLQKIM----------GMEFSEEKIQYLVYQMLKGLKY 160 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 H ++HRDLKP NL +N+ +LK+ DFGLAR + + VVT WYRAP+V++ Sbjct: 161 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILSW 217 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL---- 239 Y+ ++DIWS GCI+AEM+TGK LF G + +QL I + G P V KL Sbjct: 218 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF---VQKLNDKA 274 Query: 240 -PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 Y ++ Q P +D Q+ + + D L +L+L+ D RL+A QAL HP+F Sbjct: 275 AKSYIQSLPQTPRKDFTQLFPRASPQA-----ADLLEKMLELDVDKRLTAAQALTHPFFE 329 Query: 299 EY 300 + Sbjct: 330 PF 331 >3OHT-A nrPDB Length = 389 Score = 174 bits (442), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 102/304 (33%), Positives = 173/304 (56%), Gaps = 22/304 (7%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST-AIREISLMKELKHEN 64 +++ L +G+G Y +V + +G+ +A+K++ + + RE+ L+K +KHEN Sbjct: 52 RYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 111 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLEL--NLVKYFQWQLLQGLA 122 ++ L DV L EF D L ++ + N + +L + V++ +Q+L+GL Sbjct: 112 VIGLLDVFTPATSLE---EFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLK 168 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 + H I+HRDLKP NL +N+ +LK+ DFGLAR + + V T WYRAP++++ Sbjct: 169 YIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD---DEMTGYVATRWYRAPEIMLN 225 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK- 241 Y+ ++DIWS GCI+AE++TG+ LFPGT+ QL+ I + GTP S+ ++++P Sbjct: 226 WMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASV---ISRMPSH 282 Query: 242 ----YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 Y ++ Q P R+ V PL +D L +L L+ D R++A +AL HP+F Sbjct: 283 EARNYINSLPQMPKRNFADVFI--GANPL---AVDLLEKMLVLDTDKRITASEALAHPYF 337 Query: 298 AEYY 301 ++Y+ Sbjct: 338 SQYH 341 >3GC9-A nrPDB Length = 370 Score = 169 bits (427), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 101/306 (33%), Positives = 169/306 (55%), Gaps = 26/306 (8%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST-AIREISLMKELKHEN 64 + + L +G+G Y +V + VA+K++ + + RE+ L+K LKHEN Sbjct: 29 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 88 Query: 65 IVRLYDV------IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 ++ L DV I +++ LV M DL + S+ + + V++ +QLL Sbjct: 89 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQALSD-------EHVQFLVYQLL 141 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 +GL + H I+HRDLKP N+ +N+ +L++ DFGLAR + + V T WYRAP+ Sbjct: 142 RGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGY---VATRWYRAPE 198 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 +++ Y+ ++DIWS GCI+AE++ GK LFPG++ +QLK I +++GTP+ + ++ Sbjct: 199 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 258 Query: 239 LPKYNPNIQQRPP---RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 IQ PP +DL + + PL +D L +L L+ D R+SA +AL H Sbjct: 259 -EHARTYIQSLPPMPQKDLSSIFR--GANPL---AIDLLGRMLVLDSDQRVSAAEALAHA 312 Query: 296 WFAEYY 301 +F++Y+ Sbjct: 313 YFSQYH 318 >5Z33-A nrPDB Length = 425 Score = 167 bits (423), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 108/312 (34%), Positives = 162/312 (51%), Gaps = 34/312 (10%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELK-HENIVRL 68 ++LG G Y V +N T VA+K+V + S++ A+REI L++ + H NI L Sbjct: 37 KELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCL 96 Query: 69 YDV----IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKY--FQWQLLQGLA 122 YD+ N+ L E M+ DL + S G L + F +Q+L GL Sbjct: 97 YDMDIPRPDNFNETYLYEELMECDLAAIIRS--------GQPLTDAHFQSFIYQILCGLK 148 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIP----VNTFSSEVVTLWYRAPD 178 + H +LHRDLKP NLL+N +LK+ DFGLAR F + + V T WYRAP+ Sbjct: 149 YIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPE 208 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW----- 233 +++ ++Y+ +ID+WS GCILAE++ G+P F G + +QL I I+GTPNE Sbjct: 209 IMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGS 268 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 P + + P + ++P L P + +D L +L +P R+S +QAL Sbjct: 269 PRAQEYVRNLPFMAKKPFPTLFPNANP--------DALDLLDRMLAFDPSSRISVEQALE 320 Query: 294 HPWFAEYYHHAS 305 HP+ +H AS Sbjct: 321 HPYL-HIWHDAS 331 >2I6L-A nrPDB Length = 320 Score = 167 bits (422), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 107/315 (33%), Positives = 172/315 (54%), Gaps = 32/315 (10%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 S++ L+ LG G V+ ++ VA+K++ L + A+REI +++ L H+N Sbjct: 11 SRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSV-KHALREIKIIRRLDHDN 69 Query: 65 IVRLYDVIH-------------TE-NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLV 110 IV++++++ TE N + +V E+M+ DL ++ + LE + Sbjct: 70 IVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPL------LEEH-A 122 Query: 111 KYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRG-QLKLGDFGLARAFGIPVNT---FS 166 + F +QLL+GL + H +LHRDLKP NL IN LK+GDFGLAR + S Sbjct: 123 RLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLS 182 Query: 167 SEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFD-IM 225 +VT WYR+P +L+ Y+ +ID+W+ GCI AEM+TGK LF G ++ EQ++LI + I Sbjct: 183 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIP 242 Query: 226 GTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMR 285 E ++ +P Y N P + L Q+L ++E + DFL +L +P R Sbjct: 243 VVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAV-----DFLEQILTFSPMDR 297 Query: 286 LSAKQALHHPWFAEY 300 L+A++AL HP+ + Y Sbjct: 298 LTAEEALSHPYMSIY 312 >3N9X-A nrPDB Length = 432 Score = 164 bits (415), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 115/346 (33%), Positives = 173/346 (50%), Gaps = 71/346 (20%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-REISLMKELKHENIVRLYDV 71 +G G+Y VY +K T VA+K+V E+ I REI+++ LK + I+RLYD+ Sbjct: 34 IGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLYDL 93 Query: 72 IHTEN-----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 I ++ +L +V E D+DLKK TP L +K + LL G F HE Sbjct: 94 IIPDDLLKFDELYIVLEIADSDLKKLF------KTPIFLTEEHIKTILYNLLLGENFIHE 147 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT---------------------- 164 + I+HRDLKP N L+N+ +K+ DFGLAR +T Sbjct: 148 SGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQ 207 Query: 165 FSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMI----------TGK-PLFPGT- 212 +S VVT WYRAP++++ Y+ SIDIWS GCI AE++ T + PLFPG+ Sbjct: 208 LTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLFPGSS 267 Query: 213 ----------------NDEEQLKLIFDIMGTPNESLWPSVTK--LPKYNPNIQQRPPRDL 254 ++ +QL +IF+I+GTP E ++ K + KY R P +L Sbjct: 268 CFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHRKPINL 327 Query: 255 RQVLQPHTKEP-LDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 +Q K P + + ++ L +L+ NP+ R++ QAL HP+ + Sbjct: 328 KQ------KYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKD 367 >4E7W-A nrPDB Length = 394 Score = 161 bits (408), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 105/299 (35%), Positives = 162/299 (54%), Gaps = 31/299 (10%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 72 +GNG++ V++ VA+K+V D RE+ +M+ +KH N+V L Sbjct: 48 IGNGSFGVVFQA-KLVESDEVAIKKVLQDKRFKN-----RELQIMRIVKHPNVVDLKAFF 101 Query: 73 HT------ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 ++ E L LV E++ + Y SR + + + L+K + +QLL+ LA+ H Sbjct: 102 YSNGDKKDEVFLNLVLEYVPETV--YRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHS 159 Query: 127 NKILHRDLKPQNLLINK-RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 I HRD+KPQNLL++ G LKL DFG A+ I S + + +YRAP+++ G+ Sbjct: 160 IGICHRDIKPQNLLLDPPSGVLKLIDFGSAKIL-IAGEPNVSYICSRYYRAPELIFGATN 218 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 Y+T+IDIWS GC++AE++ G+PLFPG + +QL I ++GT PS ++ NPN Sbjct: 219 YTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGT------PSREQIKTMNPN 272 Query: 246 -----IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 Q P +V +P T P D +D + LL+ P RL+A +AL HP+F E Sbjct: 273 YMEHKFPQIRPHPFSKVFRPRT--PPDA--IDLISRLLEYTPSARLTAIEALCHPFFDE 327 >3NIE-A nrPDB Length = 429 Score = 157 bits (397), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 114/348 (32%), Positives = 171/348 (49%), Gaps = 72/348 (20%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-REISLMKELKHENIVRLYDV 71 +G G+Y VY +K VA+K+V E+ I REI+++ LK + I+RL+D+ Sbjct: 36 IGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLHDL 95 Query: 72 IHTEN-----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 I E+ +L +V E D+DLKK TP L VK + LL G F HE Sbjct: 96 IIPEDLLKFDELYIVLEIADSDLKKLF------KTPIFLTEQHVKTILYNLLLGEKFIHE 149 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGI--------------------PVNT-- 164 + I+HRDLKP N L+N+ +K+ DFGLAR P N Sbjct: 150 SGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHNKNL 209 Query: 165 ---FSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMI----------TGK-PLFP 210 +S VVT WYRAP++++ Y+ SIDIWS GCI AE++ T + PLFP Sbjct: 210 KKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRFPLFP 269 Query: 211 GT-----------------NDEEQLKLIFDIMGTPNESLWPSVTK--LPKYNPNIQQRPP 251 G+ ++ +QL +IF+++GTP E +TK + KY I+ P Sbjct: 270 GSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKY---IKLFPT 326 Query: 252 RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 RD + + ++ +G +D L +L+ N R++ +AL HP+ + Sbjct: 327 RDGIDLSKKYSSISKEG--IDLLESMLRFNAQKRITIDKALSHPYLKD 372 >4QNY-A nrPDB Length = 354 Score = 157 bits (397), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 97/305 (31%), Positives = 152/305 (49%), Gaps = 25/305 (8%) Query: 13 LGNGTYATVYKGLN-KTTGVYVALKEV--KLDSEEGTPSTAIREISLMKELKHENIVRLY 69 +G G+Y V + + K+ VA+K V ++ E +REI L+ +NI+ L Sbjct: 28 IGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNIIGLR 87 Query: 70 DVIHTEN-----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNL--VKYFQWQLLQGLA 122 +++ E+ +V + M+ DLK+ + S G EL +++F +Q L+ L Sbjct: 88 NILTPEDPENFDHFYIVMDIMETDLKQVLRS--------GQELTEAHIQFFIYQALRALH 139 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 H ++HRD+ P N+L+N LK+ DFGLA+ + V WYRAP+++M Sbjct: 140 IIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVME 199 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV--TKLP 240 + YS ID+W GCIL E++ +PLF G + QL I D++GTP+E SV + Sbjct: 200 DKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAAQ 259 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 KY RP D RQ + E L D L +L NP R++ QA+ HP+ + Sbjct: 260 KYLKKKSHRPQADWRQRYPTASPEAL-----DLLRHMLVFNPKRRITVLQAMRHPFLEQL 314 Query: 301 YHHAS 305 + A Sbjct: 315 HDDAD 319 >3EB0-A nrPDB Length = 383 Score = 157 bits (396), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 107/340 (31%), Positives = 172/340 (50%), Gaps = 62/340 (18%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 +SS ++ + LG G++ V + + +G ALK+V D P RE+ +MK L Sbjct: 4 TSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQD-----PRYKNRELDIMKVLD 58 Query: 62 HENIVRLYDVIHT-------------------------------------ENK-LTLVFE 83 H NI++L D +T +NK L ++ E Sbjct: 59 HVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIME 118 Query: 84 FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLIN- 142 ++ + L K + S + R + +NL+ + +QL + + F H I HRD+KPQNLL+N Sbjct: 119 YVPDTLHKVLKSFI--RSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNS 176 Query: 143 KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEM 202 K LKL DFG A+ IP + + + +YRAP++++G+ Y+ SID+WS GC+ E+ Sbjct: 177 KDNTLKLCDFGSAKKL-IPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGEL 235 Query: 203 ITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQ-RPP----RDLRQV 257 I GKPLF G +QL I IMGTP + ++ + NP+ + R P +D R++ Sbjct: 236 ILGKPLFSGETSIDQLVRIIQIMGTPTKE------QMIRMNPHYTEVRFPTLKAKDWRKI 289 Query: 258 LQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 L P L +D L +L+ PD+R++ +A+ HP+F Sbjct: 290 L-PEGTPSL---AIDLLEQILRYEPDLRINPYEAMAHPFF 325 >5AIR-A nrPDB Length = 430 Score = 150 bits (380), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 98/300 (32%), Positives = 160/300 (53%), Gaps = 32/300 (10%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 72 +GNG++ VY+ +G VA+K+V D RE+ +M++L H NIVRL Sbjct: 72 IGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-----RELQIMRKLDHCNIVRLRYFF 126 Query: 73 HTENK------LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 ++ + L LV +++ + Y +R + L + VK + +QL + LA+ H Sbjct: 127 YSSGEKKDEVYLNLVLDYVPETV--YRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS 184 Query: 127 NKILHRDLKPQNLLIN-KRGQLKLGDFGLARAF--GIPVNTFSSEVVTLWYRAPDVLMGS 183 I HRD+KPQNLL++ LKL DFG A+ G P ++ + + +YRAP+++ G+ Sbjct: 185 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGA 241 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPN----ESLWPSVTKL 239 Y++SID+WS GC+LAE++ G+P+FPG + +QL I ++GTP + P+ T+ Sbjct: 242 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF 301 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 K+ P I+ P +V +P T + LL+ P RL+ +A H +F E Sbjct: 302 -KF-PQIKAHP---WTKVFRPRTPP----EAIALCSRLLEYTPTARLTPLEACAHSFFDE 352 >3E3P-A nrPDB Length = 360 Score = 148 bits (373), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 107/318 (33%), Positives = 167/318 (52%), Gaps = 38/318 (11%) Query: 9 QLEKL-GNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK---HEN 64 Q+E++ G GT+ TV G K+TG+ VA+K+V D P RE+ +M++L H N Sbjct: 26 QVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQD-----PRFRNRELQIMQDLAVLHHPN 80 Query: 65 IVRLYDVIHTENK-------LTLVFEFMDNDLKKYMDS---RTVGNTPRGLELNLVKYFQ 114 IV+L +T + L +V E++ + L + + R V P L+K F Sbjct: 81 IVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPP-----ILIKVFL 135 Query: 115 WQLLQGLAFCH--ENKILHRDLKPQNLLINKR-GQLKLGDFGLARAFGIPVNTFSSEVVT 171 +QL++ + H + HRD+KP N+L+N+ G LKL DFG A+ P + + + Sbjct: 136 FQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLS-PSEPNVAYICS 194 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 +YRAP+++ G++ Y+T++DIWS GCI AEM+ G+P+F G N QL I ++G P+ Sbjct: 195 RYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSRE 254 Query: 232 ----LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 L PS T + YN + P V H+ + D L LLQ P+ R+ Sbjct: 255 VLRKLNPSHTDVDLYN---SKGIP--WSNVFSDHSLKDAK-EAYDLLSALLQYLPEERMK 308 Query: 288 AKQALHHPWFAEYYHHAS 305 +AL HP+F E + A+ Sbjct: 309 PYEALCHPYFDELHDPAT 326 >3PG1-A nrPDB Length = 362 Score = 147 bits (370), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 93/307 (30%), Positives = 157/307 (51%), Gaps = 30/307 (9%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEV----------KLDSEEGTPSTAIREISLMKELKH 62 + +G+Y V G++ + G+ VA+K V + S+ +REI L+ H Sbjct: 30 ISSGSYGAVCAGVD-SEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHFHH 88 Query: 63 ENIVRLYDV-IHTE----NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 NI+ L D+ +H E +KL LV E M DL + + + + +P+ ++YF + + Sbjct: 89 PNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQH-----IQYFMYHI 143 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 L GL HE ++HRDL P N+L+ + + DF LAR N + V WYRAP Sbjct: 144 LLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANK-THYVTHRWYRAP 202 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTP---NESLWP 234 +++M + ++ +D+WS GC++AEM K LF G+ QL I +++GTP + ++ Sbjct: 203 ELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMFS 262 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 S + ++ P R V+ T +P+ +D + +L+ NP R+S +QAL H Sbjct: 263 SPSARDYLRNSLSNVPARAWTAVVP--TADPV---ALDLIAKMLEFNPQRRISTEQALRH 317 Query: 295 PWFAEYY 301 P+F + Sbjct: 318 PYFESLF 324 >5Y86-A nrPDB Length = 588 Score = 146 bits (369), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 106/328 (32%), Positives = 169/328 (51%), Gaps = 45/328 (13%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 +++ L+ +G G++ V + + YVALK V+ +E+ A EI +++ LK ++ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKRFHRQAAEEIRILEHLKKQDK 265 Query: 66 VRLYDVIHT------ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 +VIH N + + FE + DL + + N +G + LV+ F +LQ Sbjct: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK----NKFQGFSVQLVRKFAQSILQ 321 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 L H+NKI+H DLKP+N+L+ G+ K+ DFG + + + + +YRAP Sbjct: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG---SSCFEYQKLYTYIQSRFYRAP 378 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 ++++GSR YST IDIWS GCILAE++TG+PLFPG ++ +QL + +++G P L + Sbjct: 379 EIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLL-EQS 436 Query: 238 KLPKYNPNIQQRP-------PRDLRQVL------------QPHTKE---PLDGN----LM 271 K KY N + P D R VL P +K+ L G + Sbjct: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 Query: 272 DFLHGLLQLNPDMRLSAKQALHHPWFAE 299 +FL L +P RL+ QAL HPW ++ Sbjct: 497 EFLKRCLHWDPSARLTPAQALRHPWISK 524 >3E7O-A nrPDB Length = 360 Score = 144 bits (363), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 95/316 (30%), Positives = 158/316 (50%), Gaps = 29/316 (9%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST-AIREISLMKELKHEN 64 +++QL+ +G+G V + G+ VA+K++ + T + A RE+ L+K + H+N Sbjct: 23 RYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKN 82 Query: 65 IVRLYDVIHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 I+ L +V + L LV E MD +L + + L+ + Y +Q+L Sbjct: 83 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME--------LDHERMSYLLYQML 134 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 G+ H I+HRDLKP N+++ LK+ DFGLAR + VVT +YRAP+ Sbjct: 135 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNF-MMTPYVVTRYYRAPE 193 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 V++G Y ++DIWS GCI+ E++ G +F GT+ +Q + + +GTP+ ++ Sbjct: 194 VILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQ- 251 Query: 239 LPKYNPNIQQRP--PRDLRQVLQPHTKEPLD--------GNLMDFLHGLLQLNPDMRLSA 288 P ++ RP P + L P P + D L +L ++PD R+S Sbjct: 252 -PTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISV 310 Query: 289 KQALHHPWFAEYYHHA 304 +AL HP+ +Y A Sbjct: 311 DEALRHPYITVWYDPA 326 >5ZTN-A nrPDB Length = 429 Score = 143 bits (360), Expect = 9e-35, Method: Compositional matrix adjust. Identities = 99/325 (30%), Positives = 173/325 (53%), Gaps = 43/325 (13%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 +++ L+ +G G++ V K + +VALK V+ +E+ A EI +++ L+ ++ Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVR--NEKRFHRQAAEEIRILEHLRKQDK 155 Query: 66 VRLYDVIHT------ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 +VIH N + + FE + +L + + N +G L LV+ F +LQ Sbjct: 156 DNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKK----NKFQGFSLPLVRKFAHSILQ 211 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 L H+N+I+H DLKP+N+L+ ++G+ +K+ DFG + V T+ + + +YRAP Sbjct: 212 CLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTY---IQSRFYRAP 268 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESL----- 232 +V++G+R Y ID+WS GCILAE++TG PL PG ++ +QL + +++G P++ L Sbjct: 269 EVILGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASK 327 Query: 233 ----WPSVTKLPKY-------NPNIQQRPPRDLRQVLQ--PHTKE---PLDGN----LMD 272 + S P+Y + ++ R R L+ P ++E L G +D Sbjct: 328 RAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLD 387 Query: 273 FLHGLLQLNPDMRLSAKQALHHPWF 297 FL L+ +P +R++ QAL HPW Sbjct: 388 FLKQCLEWDPAVRMTPGQALRHPWL 412 >3RP9-A nrPDB Length = 458 Score = 141 bits (356), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 101/353 (28%), Positives = 164/353 (46%), Gaps = 77/353 (21%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-REISLMKELKHENIVRLYDV 71 +G G+Y V + +K VA+K++ E+ I REI+++ L H+++V++ D+ Sbjct: 61 IGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDI 120 Query: 72 IHTEN-----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 + ++ +L +V E D+D KK TP L +K + LL G+ + H Sbjct: 121 VIPKDVEKFDELYVVLEIADSDFKKLF------RTPVYLTELHIKTLLYNLLVGVKYVHS 174 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN-----------------TF---- 165 ILHRDLKP N L+N+ +K+ DFGLAR P N TF Sbjct: 175 AGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTK 234 Query: 166 ------SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-----------GKPL 208 + VVT WYRAP++++ Y+ +ID+WS GCI AE++ PL Sbjct: 235 NLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPL 294 Query: 209 FPGTN--------------------DEEQLKLIFDIMGTPNESLWPSVTK--LPKYNPNI 246 FPG++ + +QL +IF+I+GTP+E ++ K +Y Sbjct: 295 FPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIF 354 Query: 247 QQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 +R DL + + + + L +L NP+ R++ + L HP+F E Sbjct: 355 PKREGTDLAERFPASS-----ADAIHLLKRMLVFNPNKRITINECLAHPFFKE 402 >5AWM-A nrPDB Length = 394 Score = 140 bits (353), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 99/315 (31%), Positives = 154/315 (48%), Gaps = 30/315 (9%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST-AIREISLMKELKHE 63 S++ L +G+G V + T VA+K++ + T + A RE LMK + H+ Sbjct: 44 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 103 Query: 64 NIVRLYDVIHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 NI+ L + + L LV E MD +L + + L+ + + Y +Q+ Sbjct: 104 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM--------DLDHDRMSYLLYQM 155 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 L G+ H I+HRDLKP N+++ LK+ DFGLAR G + VVT +YRAP Sbjct: 156 LCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAP 214 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +V++G Y+ ++DIWS GCI+ EMI G LFPGT+ +Q I + +GTP+ S + Sbjct: 215 EVILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 273 Query: 238 KLPKYNPNIQQRPPRDLRQV--LQPHTKEPLDGN---------LMDFLHGLLQLNPDMRL 286 P ++ RP L P P D N + L +L ++P+ R+ Sbjct: 274 --PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI 331 Query: 287 SAKQALHHPWFAEYY 301 S +AL H + +Y Sbjct: 332 SVDEALKHEYINVWY 346 >1JNK-A nrPDB Length = 423 Score = 137 bits (346), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 96/316 (30%), Positives = 151/316 (47%), Gaps = 29/316 (9%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST-AIREISLMKELKHEN 64 +++ L+ +G+G V + VA+K++ + T + A RE+ LMK + H+N Sbjct: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 Query: 65 IVRLYDVIHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 I+ L +V + L LV E MD +L + + L+ + Y +Q+L Sbjct: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--------LDHERMSYLLYQML 174 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 G+ H I+HRDLKP N+++ LK+ DFGLAR G + VVT +YRAP+ Sbjct: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPE 233 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 V++G Y ++DIWS GCI+ EM+ K LFPG + +Q + + +GTP + Sbjct: 234 VILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ- 291 Query: 239 LPKYNPNIQQRP-------PRDLRQVLQPHTKEP---LDGNLMDFLHGLLQLNPDMRLSA 288 P ++ RP P+ L P E D L +L ++P R+S Sbjct: 292 -PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 Query: 289 KQALHHPWFAEYYHHA 304 AL HP+ +Y A Sbjct: 351 DDALQHPYINVWYDPA 366 >3FI2-A nrPDB Length = 353 Score = 137 bits (345), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 95/313 (30%), Positives = 150/313 (47%), Gaps = 29/313 (9%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST-AIREISLMKELKHEN 64 +++ L+ +G+G V + VA+K++ + T + A RE+ LMK + H+N Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 84 Query: 65 IVRLYDVIHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 I+ L +V + L LV E MD +L + + L+ + Y +Q+L Sbjct: 85 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--------LDHERMSYLLYQML 136 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 G+ H I+HRDLKP N+++ LK+ DFGLAR G + VVT +YRAP+ Sbjct: 137 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPE 195 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 V++G Y ++DIWS GCI+ EM+ K LFPG + +Q + + +GTP + Sbjct: 196 VILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ- 253 Query: 239 LPKYNPNIQQRP-------PRDLRQVLQPHTKEP---LDGNLMDFLHGLLQLNPDMRLSA 288 P ++ RP P+ L P E D L +L ++P R+S Sbjct: 254 -PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 312 Query: 289 KQALHHPWFAEYY 301 AL HP+ +Y Sbjct: 313 DDALQHPYINVWY 325 >2XS0-A nrPDB Length = 386 Score = 137 bits (344), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 98/312 (31%), Positives = 154/312 (49%), Gaps = 27/312 (8%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST-AIREISLMKELKHEN 64 +++ L+ +G+G V + VA+K++ + T + A RE+ LMK + H+N Sbjct: 27 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 86 Query: 65 IVRLYDVIHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 I+ L +V + L +V E MD +L + + L+ + Y +Q+L Sbjct: 87 IIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME--------LDHERMSYLLYQML 138 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 G+ H I+HRDLKP N+++ LK+ DFGLAR G VVT +YRAP+ Sbjct: 139 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMVPFVVTRYYRAPE 197 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPN----ESLWP 234 V++G Y ++DIWS GCI+ EMI G LFPGT+ +Q + + +GTP + L P Sbjct: 198 VILGM-GYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQP 256 Query: 235 SVTKL----PKYNP-NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 +V PKY + ++ P L H K D L +L ++ R+S Sbjct: 257 TVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKA-SQARDLLSKMLVIDASKRISVD 315 Query: 290 QALHHPWFAEYY 301 +AL HP+ +Y Sbjct: 316 EALQHPYINVWY 327 >5YKS-A nrPDB Length = 377 Score = 131 bits (329), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 93/291 (31%), Positives = 143/291 (49%), Gaps = 49/291 (16%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEV---KLDSEEGTPSTAIREISLMKELKHENIVRLY 69 LG G +A V + TG VA+K + KLD+ +E+ MK ++H NIVRLY Sbjct: 43 LGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL--ATGHLFQEVRCMKLVQHPNIVRLY 100 Query: 70 DVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 +VI T+ KL L+ E D D+ Y + GL +L K + Q++ +++CH+ Sbjct: 101 EVIDTQTKLYLILELGDGGDMFDY-----IMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 155 Query: 129 ILHRDLKPQNLLI-NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYS 187 ++HRDLKP+N++ K+G +KL DFG + F P ++ +L Y AP++L+G + Sbjct: 156 VVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQ-PGKKLTTSCGSLAYSAPEILLGDEYDA 214 Query: 188 TSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS-VTKLPKYNPNI 246 ++DIWS G IL ++ G+P F ND E L +I D T PS V+K K Sbjct: 215 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYT-----VPSHVSKECK----- 264 Query: 247 QQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 D + +LQ +P R S ++ +HPW Sbjct: 265 -------------------------DLITRMLQRDPKRRASLEEIENHPWL 290 >4LFI-A nrPDB Length = 374 Score = 129 bits (323), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 81/245 (33%), Positives = 141/245 (57%), Gaps = 18/245 (7%) Query: 62 HENIVRLYDVIHTENKLT--LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H NI+ L+D+I T LVFE++DN +D R + LE ++++ ++LL+ Sbjct: 132 HANIIHLFDIIKDPISKTPALVFEYVDN-----VDFRILYPKLTDLE---IRFYMFELLK 183 Query: 120 GLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 L +CH I+HRD+KP N++I+ K +L+L D+GLA + + + ++ V + +++ P+ Sbjct: 184 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASRFFKGPE 242 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPN--ESLWPS 235 +L+ R Y S+D+WS G +LA MI + P F GT++ +QL I ++GT + + L Sbjct: 243 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 302 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGN--LMDFLHGLLQLNPDMRLSAKQALH 293 LP+ ++ Q + + + K L GN ++D + LL+ + RL+AK+A+ Sbjct: 303 EITLPREFYDMDQYIRKPWHRFINDGNKH-LSGNDEIIDLIDNLLRYDHQERLTAKEAMG 361 Query: 294 HPWFA 298 HPWFA Sbjct: 362 HPWFA 366 >6O6Q-A nrPDB Length = 335 Score = 126 bits (316), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 88/303 (29%), Positives = 160/303 (52%), Gaps = 30/303 (9%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHENI 65 ++ L KLG G Y+ V+ G++ V +K +K + REIS++K L NI Sbjct: 43 YEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIK----REISILKNLVDGPNI 98 Query: 66 VRLYDVIHTENKLT--LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 + + DV+ T L+FE ++N +D R++ T + ++++ ++LL+ L + Sbjct: 99 IAMLDVVREPQSKTPGLIFEHINN-----IDFRSLYPTFTDYD---IRFYMYELLKALDY 150 Query: 124 CHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 H I+HRD+KP N++I+ + L+L D+GLA + P ++ V + +++ P++L+ Sbjct: 151 SHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYH-PGTEYNVRVASRYFKGPELLVD 209 Query: 183 SRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 R Y S+D+WS GC+LA M+ K P F G ++ +QL I ++G+ N + L K Sbjct: 210 YRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKY-----LEK 264 Query: 242 YN-------PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 YN +I R + + + K+ + +D + LL+ + RL+AK+A+ H Sbjct: 265 YNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKH 324 Query: 295 PWF 297 +F Sbjct: 325 AYF 327 >4MVF-A nrPDB Length = 506 Score = 126 bits (316), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 93/292 (31%), Positives = 137/292 (46%), Gaps = 42/292 (14%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 EKLG GTY VYKG++K T A+KE K D + + +EI +MK+L H NIV+LY+ Sbjct: 63 EKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNI-NRFFQEIEIMKKLDHPNIVKLYE 121 Query: 71 VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 +N + L+ E ++ DS + E N + Q+ + + H I+ Sbjct: 122 TYENDNYIYLIMELCSG--RELFDS--IIENGSFTEKNAATIMK-QIFSAIFYLHSLNIV 176 Query: 131 HRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYS 187 HRDLKP+N L NK LK+ DFGL++ G T +++ T +Y AP VL G Y Sbjct: 177 HRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFT-TTKAGTPYYVAPQVLDGK--YD 233 Query: 188 TSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQ 247 DIWS G I+ ++ G P F G D E LK + E+ W S++ K Sbjct: 234 KKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAK------ 287 Query: 248 QRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + + LL NP+ R + ++AL+HPW + Sbjct: 288 ------------------------NLITKLLTYNPNERCTIEEALNHPWITQ 315 >6HMD-A nrPDB Length = 365 Score = 125 bits (314), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 86/306 (28%), Positives = 161/306 (52%), Gaps = 27/306 (8%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 + ++ + KLG G Y+ V++ +N T + V + RE+ +++ L+ Sbjct: 51 NQDDYQLVRKLGRGKYSEVFEAINITNNE----RVVVKILKPVKKKKIKREVKILENLRG 106 Query: 63 -ENIVRLYDVIHTENKLT--LVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 NI++L D + T LVFE+++N D K+ T + ++++ ++LL Sbjct: 107 GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---------IRFYMYELL 157 Query: 119 QGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + L +CH I+HRD+KP N++I+ ++ +L+L D+GLA F P ++ V + +++ P Sbjct: 158 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGP 216 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 ++L+ + Y S+D+WS GC+LA MI + P F G ++ +QL I ++GT E L+ + Sbjct: 217 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT--EELYGYL 274 Query: 237 TKL-----PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 K P +N + Q + + + + +D L LL+ + RL+AK+A Sbjct: 275 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 334 Query: 292 LHHPWF 297 + HP+F Sbjct: 335 MEHPYF 340 >6EII-A nrPDB Length = 352 Score = 122 bits (307), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 84/305 (27%), Positives = 156/305 (51%), Gaps = 25/305 (8%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 + ++ + KLG G Y+ V++ +N T VK+ L Sbjct: 58 NQDDYQLVRKLGRGKYSEVFEAINITNN---EKVVVKILKPVKKKKIKREIKILENLRGG 114 Query: 63 ENIVRLYDVIHTENKLT--LVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 NI+ L D++ T LVFE ++N D K+ + T + ++++ +++L+ Sbjct: 115 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD---------IRFYMYEILK 165 Query: 120 GLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 L +CH I+HRD+KP N++I+ + +L+L D+GLA F P ++ V + +++ P+ Sbjct: 166 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPE 224 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +L+ + Y S+D+WS GC+LA MI K P F G ++ +QL I ++GT E L+ + Sbjct: 225 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT--EDLYDYID 282 Query: 238 KL-----PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 K P++N + + + + + + + +DFL LL+ + RL+A++A+ Sbjct: 283 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 342 Query: 293 HHPWF 297 HP+F Sbjct: 343 EHPYF 347 >4IAN-A nrPDB Length = 358 Score = 122 bits (305), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 96/320 (30%), Positives = 154/320 (48%), Gaps = 42/320 (13%) Query: 14 GNGTYATVYKGL-NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN------IV 66 G G ++ V + N VA+K ++ + E T ++E+ +K+L + + Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIR--NNELMQKTGLKELEFLKKLNDADPDDKFHCL 96 Query: 67 RLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 RL+ + + L LVFE + +L++ + + G GL + V+ + QL L Sbjct: 97 RLFRHFYHKQHLCLVFEPLSMNLREVL--KKYGKDV-GLHIKAVRSYSQQLFLALKLLKR 153 Query: 127 NKILHRDLKPQNLLINK-RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 ILH D+KP N+L+N+ + LKL DFG A + N + +V+ +YRAP++++G ++ Sbjct: 154 CNILHADIKPDNILVNESKTILKLCDFG--SASHVADNDITPYLVSRFYRAPEIIIG-KS 210 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGT-PNESLWPSVTKLPKYNP 244 Y ID+WS GC L E+ TGK LFPG + LKL D+ G PN+ + V K ++ Sbjct: 211 YDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQ 270 Query: 245 N----------IQQR----------PPRDLRQVLQPHTKEPLDG-----NLMDFLHGLLQ 279 N + +R P +DL L + P D L D L +L Sbjct: 271 NLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILM 330 Query: 280 LNPDMRLSAKQALHHPWFAE 299 L+P R+S QAL H + E Sbjct: 331 LDPAKRISINQALQHAFIQE 350 >4MD7-E nrPDB Length = 391 Score = 121 bits (304), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 84/305 (27%), Positives = 156/305 (51%), Gaps = 25/305 (8%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 + ++ + KLG G Y+ V++ +N T VK+ L Sbjct: 35 NQDDYQLVRKLGRGKYSEVFEAINITNN---EKVVVKILKPVKKKKIKREIKILENLRGG 91 Query: 63 ENIVRLYDVIHTENKLT--LVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 NI+ L D++ T LVFE ++N D K+ + T + ++++ +++L+ Sbjct: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYD---------IRFYMYEILK 142 Query: 120 GLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 L +CH I+HRD+KP N++I+ + +L+L D+GLA F P ++ V + +++ P+ Sbjct: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPE 201 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +L+ + Y S+D+WS GC+LA MI K P F G ++ +QL I ++GT E L+ + Sbjct: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT--EDLYDYID 259 Query: 238 KL-----PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 K P++N + + + + + + + +DFL LL+ + RL+A++A+ Sbjct: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319 Query: 293 HHPWF 297 HP+F Sbjct: 320 EHPYF 324 >3MN3-A nrPDB Length = 271 Score = 121 bits (304), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 82/293 (27%), Positives = 146/293 (49%), Gaps = 43/293 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKELKHEN 64 ++ ++ LG G++ V + TTG VALK + K+ ++ REIS ++ L+H + Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 65 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 I++LYDVI +++++ +V E+ N+L Y+ R + E ++FQ Q++ + +C Sbjct: 66 IIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRD-----KMSEQEARRFFQ-QIISAVEYC 119 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 H +KI+HRDLKP+NLL+++ +K+ DFGL+ N + + Y AP+V+ G Sbjct: 120 HRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIM-TDGNFLKTSCGSPNYAAPEVISGKL 178 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 +D+WSCG IL M+ + F D+E + ++F +++ V LPK+ Sbjct: 179 YAGPEVDVWSCGVILYVMLCRRLPF----DDESIPVLF-------KNISNGVYTLPKF-- 225 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 L + +L +NP R+S + + WF Sbjct: 226 ---------------------LSPGAAGLIKRMLIVNPLNRISIHEIMQDDWF 257 >3MA6-A nrPDB Length = 298 Score = 120 bits (300), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 89/303 (29%), Positives = 144/303 (47%), Gaps = 45/303 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKELK 61 S ++K LG G++ V +K TG A+K + + ++ + +RE+ L+K+L Sbjct: 31 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLD 90 Query: 62 HENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H NI++LY+ + LV E + +L + SR R E++ + + Q+L G Sbjct: 91 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISR-----KRFSEVDAARIIR-QVLSG 144 Query: 121 LAFCHENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + + H+NKI+HRDLKP+NLL+ +K +++ DFGL+ F ++ T +Y AP Sbjct: 145 ITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEAS-KKMKDKIGTAYYIAP 203 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +VL G TY D+WS G IL +++G P F G N+ + LK + T W V+ Sbjct: 204 EVLHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVS 261 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + K D + +L P MR+SA+ AL H W Sbjct: 262 ESAK------------------------------DLIRKMLTYVPSMRISARDALDHEWI 291 Query: 298 AEY 300 Y Sbjct: 292 QTY 294 >5JN2-A nrPDB Length = 525 Score = 119 bits (299), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 89/303 (29%), Positives = 144/303 (47%), Gaps = 45/303 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKELK 61 S ++K LG G++ V +K TG A+K + + ++ + +RE+ L+K+L Sbjct: 66 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLD 125 Query: 62 HENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H NI++LY+ + LV E + +L + SR R E++ + + Q+L G Sbjct: 126 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISR-----KRFSEVDAARIIR-QVLSG 179 Query: 121 LAFCHENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + + H+NKI+HRDLKP+NLL+ +K +++ DFGL+ F ++ T +Y AP Sbjct: 180 ITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEAS-KKMKDKIGTAYYIAP 238 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +VL G TY D+WS G IL +++G P F G N+ + LK + T W V+ Sbjct: 239 EVLHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVS 296 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + K D + +L P MR+SA+ AL H W Sbjct: 297 ESAK------------------------------DLIRKMLTYVPSMRISARDALDHEWI 326 Query: 298 AEY 300 Y Sbjct: 327 QTY 329 >2WO6-A nrPDB Length = 382 Score = 117 bits (294), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 92/327 (28%), Positives = 155/327 (47%), Gaps = 50/327 (15%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 72 +G G++ V K ++ +VA+K +K +++ + A E+ L++ + + Y ++ Sbjct: 62 IGKGSFGQVVKAYDRVEQEWVAIKIIK--NKKAFLNQAQIEVRLLELMNKHDTEMKYYIV 119 Query: 73 HTE------NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH- 125 H + N L LVFE + +L + + RG+ LNL + F Q+ L F Sbjct: 120 HLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNF----RGVSLNLTRKFAQQMCTALLFLAT 175 Query: 126 -ENKILHRDLKPQNLLIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 E I+H DLKP+N+L+ KR +K+ DFG + G + + + + +YR+P+VL+G Sbjct: 176 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQY---IQSRFYRSPEVLLG 232 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV------ 236 Y +ID+WS GCIL EM TG+PLF G N+ +Q+ I +++G P + Sbjct: 233 M-PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKF 291 Query: 237 -TKLPKYNPNIQQ--------RPP--RDLRQVLQPHTKEPLDG-------------NLMD 272 KLP N+++ +PP R L +L T P D Sbjct: 292 FEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKD 351 Query: 273 FLHGLLQLNPDMRLSAKQALHHPWFAE 299 + +L +P R+ AL H +F + Sbjct: 352 LILRMLDYDPKTRIQPYYALQHSFFKK 378 >3LIJ-A nrPDB Length = 494 Score = 117 bits (293), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 87/302 (28%), Positives = 138/302 (45%), Gaps = 46/302 (15%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKH 62 S +++++KLG+G Y V +K T V A+K ++ S + S + E++++K L H Sbjct: 36 SEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDH 95 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLV--KYFQWQLLQG 120 NI++LYD + LV E Y ++ N V Q+L G Sbjct: 96 PNIMKLYDFFEDKRNYYLVMEC-------YKGGELFDEIIHRMKFNEVDAAVIIKQVLSG 148 Query: 121 LAFCHENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + + H++ I+HRDLKP+NLL+ K +K+ DFGL+ F + T +Y AP Sbjct: 149 VTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFE-NQKKMKERLGTAYYIAP 207 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +VL + Y D+WS G IL ++ G P F G D+E L+ + T + W +V+ Sbjct: 208 EVL--RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVS 265 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + K D + +LQ + R+SA+QAL HPW Sbjct: 266 EGAK------------------------------DLIKQMLQFDSQRRISAQQALEHPWI 295 Query: 298 AE 299 E Sbjct: 296 KE 297 >3DXN-A nrPDB Length = 287 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 82/302 (27%), Positives = 143/302 (47%), Gaps = 43/302 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA--IREISLMKELK 61 S ++++++KLG+G Y V +K TG A+K +K S T ++ + E++++K+L Sbjct: 20 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD 79 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H NI++LY+ + LV E + D + ++ ++ Q+L G Sbjct: 80 HPNIMKLYEFFEDKRNYYLVMEVYRGG--ELFDEIILRQKFSEVDAAVI---MKQVLSGT 134 Query: 122 AFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 + H++ I+HRDLKP+NLL+ + + +K+ DFGL+ F + + T +Y AP+ Sbjct: 135 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVG-GKMKERLGTAYYIAPE 193 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL + Y D+WSCG IL ++ G P F G D+E LK + + + W V+ Sbjct: 194 VL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSD 251 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 K + +L P R+SA++AL+HPW Sbjct: 252 EAK------------------------------QLVKLMLTYEPSKRISAEEALNHPWIV 281 Query: 299 EY 300 ++ Sbjct: 282 KF 283 >3TAC-A nrPDB Length = 361 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 86/310 (27%), Positives = 143/310 (46%), Gaps = 50/310 (16%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI----REISLMKELKH 62 ++ E +G G ++ V + +N+ TG A+K V + +P + RE S+ LKH Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDN-----DLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 +IV L + ++ L +VFEFMD ++ K D+ V + + ++ Q+ Sbjct: 88 PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEA------VASHYMRQI 141 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKR---GQLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 L+ L +CH+N I+HRD+KP +L+ + +KLG FG+A G V T + Sbjct: 142 LEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHF 201 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 AP+V+ Y +D+W CG IL +++G F GT E L+ Sbjct: 202 MAPEVVK-REPYGKPVDVWGCGVILFILLSGCLPFYGT----------------KERLFE 244 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 + K KY N PR + + + D + +L L+P R++ +AL+H Sbjct: 245 GIIK-GKYKMN-----PRQWSHISE---------SAKDLVRRMLMLDPAERITVYEALNH 289 Query: 295 PWFAEYYHHA 304 PW E +A Sbjct: 290 PWLKERDRYA 299 >4D28-A nrPDB Length = 446 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 78/215 (36%), Positives = 115/215 (53%), Gaps = 7/215 (3%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMK 58 M +++ +G GT+A V N TG VA+K + + + REIS+MK Sbjct: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 Query: 59 ELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 ++H NIVRLY+V+ +++K+ +V EF+ + R V + R E KYFQ QL+ Sbjct: 65 IVRHPNIVRLYEVLASKSKIYIVLEFVTGG---ELFDRIV-HKGRLKEDESRKYFQ-QLV 119 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 +A CH + HRDLKP+NLL++ G LK+ DFGL+ V + T Y AP+ Sbjct: 120 DAVAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPE 179 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTN 213 VL G ++ DIWSCG IL ++ G F T+ Sbjct: 180 VLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD 214 >4RGJ-A nrPDB Length = 520 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 88/301 (29%), Positives = 146/301 (48%), Gaps = 46/301 (15%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKELK 61 + Q+K ++ LG G++ V +K TG A+K + K + + +RE+ L+K L Sbjct: 59 NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLD 118 Query: 62 HENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H NI++LY+ N LV + + +L + SR R E++ + + Q+L G Sbjct: 119 HINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISR-----KRFYEIDAARIIK-QILSG 172 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQ----LKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 + + H+N ++HRDLKP+N+L+ + + +K+ DFGL+ F ++ T +Y A Sbjct: 173 ITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYS-KKMKDKIGTAYYIA 231 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 PDVL G TY DIWSCG IL +++G P F G+N+ + LK + Sbjct: 232 PDVLHG--TYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV--------------- 274 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 + KY ++ P K+ D D + +L +R+SA+ AL H W Sbjct: 275 -EAGKYTFDL-------------PQFKKISD-KAKDLIKKMLMYTSAVRISARDALEHEW 319 Query: 297 F 297 Sbjct: 320 I 320 >2PVN-A nrPDB Length = 352 Score = 116 bits (290), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 80/306 (26%), Positives = 156/306 (50%), Gaps = 21/306 (6%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 ++ + K+G G Y+ V++G+N +K + L Sbjct: 49 GEQDDYEVVRKVGRGKYSEVFEGINVNNNEKCIIKIL---KPVKKKKIKREIKILQNLCG 105 Query: 62 HENIVRLYDVIHTENKLT--LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 NIV+L D++ ++ T L+FE+++N D + + T + ++Y+ ++LL+ Sbjct: 106 GPNIVKLLDIVRDQHSKTPSLIFEYVNN-----TDFKVLYPTLTDYD---IRYYIYELLK 157 Query: 120 GLAFCHENKILHRDLKPQNLLINKR-GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 L +CH I+HRD+KP N++I+ +L+L D+GLA F P ++ V + +++ P+ Sbjct: 158 ALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAE-FYHPGKEYNVRVASRYFKGPE 216 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +L+ + Y S+D+WS GC+ A MI K P F G ++ +QL I ++GT + + + Sbjct: 217 LLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKY 276 Query: 238 KLPKYNPNIQQRPPRDLR----QVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 ++ + +P ++ R R + + + + +DFL LL+ + RL+A +A+ Sbjct: 277 RI-ELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMT 335 Query: 294 HPWFAE 299 HP+F + Sbjct: 336 HPYFQQ 341 >5XZW-A nrPDB Length = 471 Score = 116 bits (290), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 89/306 (29%), Positives = 140/306 (45%), Gaps = 56/306 (18%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E +G G +ATV K + +TTG A+K + G RE+ ++++L H IVRL Sbjct: 202 EVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKG 261 Query: 71 VIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 +V EF+ DL ++ + G E++ Q+L + + H I Sbjct: 262 FYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREIS------RQILTAIKYIHSMGI 315 Query: 130 LHRDLKPQNLLINKRGQL--KLGDFGLARAFGIP--VNTFSSEVVTLWYRAPDVLMGSRT 185 HRDLKP N+LI + + K+ DFGLA+ G + TF TL Y AP+V+ G T Sbjct: 316 SHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCG---TLAYVAPEVIRGKDT 372 Query: 186 ------------YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 YS+ +D+WS GC++ ++TG F G+ ++ K I G+ +E Sbjct: 373 SVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIG--RGSYHEG-- 428 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 P +D R + DF+ LLQ++P+ R +A +AL+ Sbjct: 429 ----------------PLKDFR----------ISEEARDFIDSLLQVDPNNRSTAAKALN 462 Query: 294 HPWFAE 299 HPW + Sbjct: 463 HPWIVD 468 >6QAU-A nrPDB Length = 280 Score = 115 bits (289), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 75/245 (30%), Positives = 133/245 (54%), Gaps = 26/245 (10%) Query: 6 QFKQLEKLGNGTYATVYKGLNK-TTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 ++ + + +G+G +A V++G ++ T VA+K + + + +EI ++KEL+HEN Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHEN 71 Query: 65 IVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 IV LYDV N + LV E+ + DL Y+ ++ L + ++ F Q+ + Sbjct: 72 IVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGT------LSEDTIRVFLHQIAAAMRI 125 Query: 124 CHENKILHRDLKPQNLLI---NKRG------QLKLGDFGLARAFGIPVNTFSSEVV-TLW 173 H I+HRDLKPQN+L+ N+R ++K+ DFG AR + N ++++ + Sbjct: 126 LHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARY--LHSNMMAADLCGSPM 183 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 Y AP+V+M S+ Y D+WS G ++ + + GKP F N + L++ ++ N SL Sbjct: 184 YMAPEVIM-SQHYDAKADLWSIGTVIYQCLVGKPPFQ-ANSPQDLRMFYE----KNRSLM 237 Query: 234 PSVTK 238 PS+ + Sbjct: 238 PSIPR 242 >6FD3-A nrPDB Length = 300 Score = 115 bits (289), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 87/292 (29%), Positives = 134/292 (45%), Gaps = 39/292 (13%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 ++ + EK+G G TVY L+ TG VA+K++ L ++ I EI +M+E K+ NI Sbjct: 23 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNL-QQQPKKELIINEILVMRENKNPNI 81 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 V D ++L +V E++ S T T ++ + + LQ L F H Sbjct: 82 VNYLDSYLVGDELWVVMEYLAGG------SLTDVVTETCMDEGQIAAVCRECLQALDFLH 135 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 N+++HRD+K N+L+ G +KL DFG + S+ V T ++ AP+V+ + Sbjct: 136 SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKA 194 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 Y +DIWS G + EM+ G+P + N L LI GTP Sbjct: 195 YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA-TNGTPE---------------- 237 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 Q P R L DFL+ L+++ D R SAK+ L HP+ Sbjct: 238 -LQNPER-------------LSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 275 >3HZT-A nrPDB Length = 467 Score = 115 bits (288), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 82/302 (27%), Positives = 143/302 (47%), Gaps = 43/302 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA--IREISLMKELK 61 S ++++++KLG+G Y V +K TG A+K +K S T ++ + E++++K+L Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD 62 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H NI++LY+ + LV E + D + ++ ++ Q+L G Sbjct: 63 HPNIMKLYEFFEDKRNYYLVMEVYRGG--ELFDEIILRQKFSEVDAAVI---MKQVLSGT 117 Query: 122 AFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 + H++ I+HRDLKP+NLL+ + + +K+ DFGL+ F + + T +Y AP+ Sbjct: 118 TYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVG-GKMKERLGTAYYIAPE 176 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL + Y D+WSCG IL ++ G P F G D+E LK + + + W V+ Sbjct: 177 VL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSD 234 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 K + +L P R+SA++AL+HPW Sbjct: 235 EAK------------------------------QLVKLMLTYEPSKRISAEEALNHPWIV 264 Query: 299 EY 300 ++ Sbjct: 265 KF 266 >2BDW-A nrPDB Length = 362 Score = 115 bits (287), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 98/317 (30%), Positives = 156/317 (49%), Gaps = 53/317 (16%) Query: 1 MSSSSQFKQ----LEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-REIS 55 M++S++F E+LG G ++ V + ++KTTG+ A K + + RE Sbjct: 21 MNASTKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREAR 80 Query: 56 LMKELKHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQ 114 + ++L+H NIVRL+D I E+ LVF+ + +L + + +R + E + Q Sbjct: 81 ICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYS-----EADASHCIQ 135 Query: 115 WQLLQGLAFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVN---TFSSE 168 Q+L+ +A+CH N I+HR+LKP+NLL+ + + +KL DFGLA I VN + Sbjct: 136 -QILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLA----IEVNDSEAWHGF 190 Query: 169 VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTP 228 T Y +P+VL YS +DIW+CG IL ++ G P F DE+Q +L I Sbjct: 191 AGTPGYLSPEVLKKD-PYSKPVDIWACGVILYILLVGYPPFW---DEDQHRLYAQIKAGA 246 Query: 229 NESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA 288 + +PS P+++ + P K +D +L +NP R++A Sbjct: 247 YD--YPS----PEWD-------------TVTPEAKSLID--------SMLTVNPKKRITA 279 Query: 289 KQALHHPWFAEYYHHAS 305 QAL PW AS Sbjct: 280 DQALKVPWICNRERVAS 296 >5FG8-A nrPDB Length = 285 Score = 114 bits (286), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 91/301 (30%), Positives = 146/301 (48%), Gaps = 42/301 (13%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-REISLMKELKH 62 S + E+LG G ++ V + + K+TG A K + + RE + ++L H Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHH 72 Query: 63 ENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NIVRL+D I EN LVF+ + +L + + +R + E + Q Q+L+ + Sbjct: 73 PNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYS-----EADASHCIQ-QILESV 126 Query: 122 AFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 CH+N ++HRDLKP+NLL+ + + +KL DFGLA + T Y +P+ Sbjct: 127 NHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPE 186 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL Y S+DIW+CG IL ++ G P F DE+Q +L I + +PS Sbjct: 187 VLK-KEPYGKSVDIWACGVILYILLVGYPPF---WDEDQHRLYSQIKAGAYD--YPS--- 237 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 P+++ T P NL++ +L +NP+ R++A +AL HPW Sbjct: 238 -PEWD------------------TVTPEAKNLIN---QMLTVNPNKRITAAEALKHPWIC 275 Query: 299 E 299 + Sbjct: 276 Q 276 >3KK8-A nrPDB Length = 284 Score = 114 bits (286), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 94/303 (31%), Positives = 149/303 (49%), Gaps = 49/303 (16%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-REISLMKELKH 62 S + E+LG G ++ V + ++KTTG+ A K + + RE + ++L+H Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH 64 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NIVRL+D I E+ LVF+ + +L + + +R + E + Q Q+L+ + Sbjct: 65 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYS-----EADASHCIQ-QILESI 118 Query: 122 AFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVN---TFSSEVVTLWYR 175 A+CH N I+HR+LKP+NLL+ + + +KL DFGLA I VN + T Y Sbjct: 119 AYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLA----IEVNDSEAWHGFAGTPGYL 174 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 +P+VL YS +DIW+CG IL ++ G P F DE+Q +L I + +PS Sbjct: 175 SPEVLKKD-PYSKPVDIWACGVILYILLVGYPPF---WDEDQHRLYAQIKAGAYD--YPS 228 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 P+++ + P K +D +L +NP R++A QAL P Sbjct: 229 ----PEWD-------------TVTPEAKSLID--------SMLTVNPKKRITADQALKVP 263 Query: 296 WFA 298 W Sbjct: 264 WIC 266 >3DFA-A nrPDB Length = 286 Score = 114 bits (284), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 83/294 (28%), Positives = 143/294 (48%), Gaps = 46/294 (15%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 LG G++ V K ++ T A+K + K ++ ST +RE+ L+K+L H NI++L+++ Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEI 89 Query: 72 IHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 + + +V E + +L + R R E + + + Q+ G+ + H++ I+ Sbjct: 90 LEDSSSFYIVGELYTGGELFDEIIKR-----KRFSEHDAARIIK-QVFSGITYMHKHNIV 143 Query: 131 HRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNT-FSSEVVTLWYRAPDVLMGSRTY 186 HRDLKP+N+L+ K +K+ DFGL+ F NT + T +Y AP+VL G TY Sbjct: 144 HRDLKPENILLESKEKDCDIKIIDFGLSTCF--QQNTKMKDRIGTAYYIAPEVLRG--TY 199 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNI 246 D+WS G IL +++G P F G N+ + LK + + KY ++ Sbjct: 200 DEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV----------------ETGKYAFDL 243 Query: 247 QQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 Q + + D + +L +P +R++A Q L HPW +Y Sbjct: 244 PQW--------------RTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >3NCG-A nrPDB Length = 486 Score = 113 bits (283), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 85/295 (28%), Positives = 144/295 (48%), Gaps = 48/295 (16%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 LG G++ V K ++ T A+K + K ++ ST +RE+ L+K+L H NI++L+++ Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEI 89 Query: 72 IHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 + + +V E + +L + R R E + + + Q+ G+ + H++ I+ Sbjct: 90 LEDSSSFYIVGELYTGGELFDEIIKR-----KRFSEHDAARIIK-QVFSGITYMHKHNIV 143 Query: 131 HRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNT-FSSEVVTLWYRAPDVLMGSRTY 186 HRDLKP+N+L+ K +K+ DFGL+ F NT + T +Y AP+VL G TY Sbjct: 144 HRDLKPENILLESKEKDCDIKIIDFGLSTCF--QQNTKMKDRIGTAYYIAPEVLRG--TY 199 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNI 246 D+WS G IL +++G P F G N+ + LK + + KY ++ Sbjct: 200 DEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV----------------ETGKYAFDL 243 Query: 247 QQ-RPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 Q R D + D + +L +P +R++A Q L HPW +Y Sbjct: 244 PQWRTISD---------------DAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >2UV2-A nrPDB Length = 325 Score = 113 bits (283), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 87/291 (29%), Positives = 126/291 (43%), Gaps = 44/291 (15%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 +LG+G + VYK NK T V A K + SEE + EI ++ H NIV+L D Sbjct: 44 ELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILASCDHPNIVKLLDA 102 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 + EN L ++ EF +D+ + R L + ++ Q L L + H+NKI+H Sbjct: 103 FYYENNLWILIEFCAGGA---VDAVML-ELERPLTESQIQVVCKQTLDALNYLHDNKIIH 158 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG----SRTYS 187 RDLK N+L G +KL DFG++ + S + T ++ AP+V+M R Y Sbjct: 159 RDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYD 218 Query: 188 TSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP--SVTKLPKYNPN 245 D+WS G L EM +P P+ L P + K+ K P Sbjct: 219 YKADVWSLGITLIEMAEIEP--------------------PHHELNPMRVLLKIAKSEPP 258 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 +P R N DFL L+ N D R + Q L HP+ Sbjct: 259 TLAQPSR-------------WSSNFKDFLKKCLEKNVDARWTTSQLLQHPF 296 >4WNO-A nrPDB Length = 287 Score = 112 bits (281), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 76/245 (31%), Positives = 134/245 (54%), Gaps = 26/245 (10%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTT-GVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 +F + + +G+G +A V+KG ++ + VA+K + + + + +EI ++KELKHEN Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHEN 78 Query: 65 IVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 IV LYD N + LV E+ + DL Y+ + R L + ++ F Q+ + Sbjct: 79 IVALYDFQEMANSVYLVMEYCNGGDLADYLHAM------RTLSEDTIRLFLQQIAGAMRL 132 Query: 124 CHENKILHRDLKPQNLLI-NKRG--------QLKLGDFGLARAFGIPVNTFSSEVV-TLW 173 H I+HRDLKPQN+L+ N G ++K+ DFG AR + N ++ + + Sbjct: 133 LHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARY--LQSNMMAATLCGSPM 190 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 Y AP+V+M S+ Y D+WS G I+ + +TGK F ++ ++ L+L ++ N++L Sbjct: 191 YMAPEVIM-SQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD-LRLFYE----KNKTLV 244 Query: 234 PSVTK 238 P++ + Sbjct: 245 PTIPR 249 >3EQC-A nrPDB Length = 360 Score = 112 bits (281), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 87/306 (28%), Positives = 152/306 (49%), Gaps = 27/306 (8%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F+++ +LG G V+K +K +G+ +A K + L+ + + IRE+ ++ E IV Sbjct: 35 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 94 Query: 67 RLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 Y +++ ++++ E MD L + + + G P ++ +++GL + Sbjct: 95 GFYGAFYSDGEISICMEHMDGGSLDQVL--KKAGRIPE----QILGKVSIAVIKGLTYLR 148 Query: 126 E-NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-TLWYRAPDVLMGS 183 E +KI+HRD+KP N+L+N RG++KL DFG++ G +++ ++ V T Y +P+ L G+ Sbjct: 149 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPERLQGT 205 Query: 184 RTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIF--DIMGTPNESLWPSVTKLP 240 YS DIWS G L EM G+ P+ P D ++L+L+F + G E+ T Sbjct: 206 H-YSVQSDIWSMGLSLVEMAVGRYPIPP--PDAKELELMFGCQVEGDAAETPPRPRTPGR 262 Query: 241 KYNP-NIQQRPPRDLRQVLQPHTKEP--------LDGNLMDFLHGLLQLNPDMRLSAKQA 291 N + RPP + ++L EP DF++ L NP R KQ Sbjct: 263 PLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQL 322 Query: 292 LHHPWF 297 + H + Sbjct: 323 MVHAFI 328 >5XVU-A nrPDB Length = 332 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 83/314 (26%), Positives = 160/314 (50%), Gaps = 37/314 (11%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 + ++++ ++K+G G Y+ V+ G + A+K + L Sbjct: 28 NKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVL---KPVKKKKIKREIKILQNLNG 84 Query: 62 HENIVRLYDVIH--TENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 NI++L D++ +L+FE+++N +D +T+ P+ + + ++Y+ +Q+L+ Sbjct: 85 GPNIIKLLDIVKDPVTKTPSLIFEYINN-----IDFKTL--YPKFTDKD-IRYYIYQILK 136 Query: 120 GLAFCHENKILHRDLKPQNLLINKRG-QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 L +CH I+HRD+KP N++I+ Q++L +GLA F P ++ V + +Y+ P+ Sbjct: 137 ALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAE-FYHPGQEYNVRVASRYYKGPE 195 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +L+ + Y S+DIWS GC+LA MI K P F G ++ +QL I ++GT + + Sbjct: 196 LLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAY---- 251 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEP------------LDGNLMDFLHGLLQLNPDMR 285 L KY NI+ +P +L + ++P ++D + +L + R Sbjct: 252 -LKKY--NIKLKP--HYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKR 306 Query: 286 LSAKQALHHPWFAE 299 ++ K+A+ HP+F E Sbjct: 307 IAPKEAMEHPYFRE 320 >2JC6-A nrPDB Length = 334 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 83/301 (27%), Positives = 137/301 (45%), Gaps = 52/301 (17%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F+ E LG G ++ V K TG A+K + + +G S+ EI++++++KHENIV Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 83 Query: 67 RLYDVIHTENKLTLVF------EFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 L D+ + N L LV E D ++K + +T L++ Q+L Sbjct: 84 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDAST-------LIR----QVLDA 132 Query: 121 LAFCHENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + + H I+HRDLKP+NLL ++ ++ + DFGL++ G + S+ T Y AP Sbjct: 133 VYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEG-KGDVMSTACGTPGYVAP 191 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +VL + YS ++D WS G I ++ G P F ND + + I + W ++ Sbjct: 192 EVL-AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDIS 250 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 K DF+ L++ +P+ R + +QA HPW Sbjct: 251 DSAK------------------------------DFIRNLMEKDPNKRYTCEQAARHPWI 280 Query: 298 A 298 A Sbjct: 281 A 281 >4PDS-A nrPDB Length = 347 Score = 112 bits (279), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 85/304 (27%), Positives = 136/304 (44%), Gaps = 56/304 (18%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E +G G +ATV K + +TTG ++K + G RE+ ++++L H IVRL Sbjct: 37 EVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKG 96 Query: 71 VIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 +V EF+ DL ++ + G E++ Q+L + + H I Sbjct: 97 FYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREIS------RQILTAIKYIHSMGI 150 Query: 130 LHRDLKPQNLLINKRGQL--KLGDFGLAR--AFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 HRDLKP N+LI + + K+ FGLA+ G + TF TL Y AP+V+ G T Sbjct: 151 SHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCG---TLAYVAPEVIRGKDT 207 Query: 186 ------------YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 YS+ +D+WS GC++ ++TG F G+ ++ K I Sbjct: 208 SVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIG----------- 256 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 + + P +D R + DF+ LLQ++P+ R +A +AL+ Sbjct: 257 ---------RGSYHEGPLKDFR----------ISEEARDFIDSLLQVDPNNRSTAAKALN 297 Query: 294 HPWF 297 HPW Sbjct: 298 HPWI 301 >2WQN-A nrPDB Length = 310 Score = 111 bits (278), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 71/211 (33%), Positives = 110/211 (52%), Gaps = 8/211 (3%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKH 62 + F+ +K+G G ++ VY+ GV VALK+V++ + + I+EI L+K+L H Sbjct: 32 ANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNH 91 Query: 63 ENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGL-ELNLVKYFQWQLLQG 120 N+++ Y +N+L +V E D DL + + + R + E + KYF QL Sbjct: 92 PNVIKYYASFIEDNELNIVLELADAGDLSRMI--KHFKKQKRLIPERTVWKYF-VQLCSA 148 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 L H +++HRD+KP N+ I G +KLGD GL R F S V T +Y +P+ + Sbjct: 149 LEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI 208 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPG 211 Y+ DIWS GC+L EM + F G Sbjct: 209 -HENGYNFKSDIWSLGCLLYEMAALQSPFYG 238 >6E2O-A nrPDB Length = 295 Score = 110 bits (276), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 79/205 (38%), Positives = 112/205 (54%), Gaps = 17/205 (8%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 LG GTY VY G + + V +A+KE+ + DS P EI+L K LKH+NIV+ Y Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLH--EEIALHKHLKHKNIVQ-YLG 86 Query: 72 IHTENKLTLVF--EFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 +EN +F + L + S+ P + ++ Q+L+GL + H+N+I Sbjct: 87 SFSENGFIKIFMEQVPGGSLSALLRSKW---GPLKDNEQTIGFYTKQILEGLKYLHDNQI 143 Query: 130 LHRDLKPQNLLINK-RGQLKLGDFGLA-RAFGI--PVNTFSSEVVTLWYRAPDVL-MGSR 184 +HRD+K N+LIN G LK+ DFG + R GI TF+ TL Y AP+++ G R Sbjct: 144 VHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTG---TLQYMAPEIIDKGPR 200 Query: 185 TYSTSIDIWSCGCILAEMITGKPLF 209 Y + DIWS GC + EM TGKP F Sbjct: 201 GYGKAADIWSLGCTIIEMATGKPPF 225 >5KKR-C nrPDB Length = 395 Score = 110 bits (276), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 86/306 (28%), Positives = 152/306 (49%), Gaps = 27/306 (8%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F+++ +LG G V+K +K +G+ +A K + L+ + + IRE+ ++ E IV Sbjct: 70 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 129 Query: 67 RLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 Y +++ ++++ E MD L + + + G P ++ +++GL + Sbjct: 130 GFYGAFYSDGEISICMEHMDGGSLDQVL--KKAGRIPE----QILGKVSIAVIKGLTYLR 183 Query: 126 E-NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-TLWYRAPDVLMGS 183 E +KI+HRD+KP N+L+N RG++KL DFG++ G +++ ++ V T Y +P+ L G+ Sbjct: 184 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPERLQGT 240 Query: 184 RTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIF--DIMGTPNESLWPSVTKLP 240 YS DIWS G L EM G+ P+ P D ++L+L+F + G E+ T Sbjct: 241 H-YSVQSDIWSMGLSLVEMAVGRYPIPP--PDAKELELMFGCQVEGDAAETPPRPRTPGR 297 Query: 241 KYNP-NIQQRPPRDLRQVLQPHTKEP--------LDGNLMDFLHGLLQLNPDMRLSAKQA 291 + + RPP + ++L EP DF++ L NP R KQ Sbjct: 298 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQL 357 Query: 292 LHHPWF 297 + H + Sbjct: 358 MVHAFI 363 >4UZD-A nrPDB Length = 287 Score = 110 bits (275), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 77/262 (29%), Positives = 126/262 (48%), Gaps = 36/262 (13%) Query: 13 LGNGTYATVYKGLNKTTGVYVALK---EVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 LG G + VY K + +ALK + +L+ + G RE+ + L+H NI+RLY Sbjct: 16 LGKGKFGNVYLAREKQSKFILALKVLFKAQLE-KAGVEHQLRREVEIQSHLRHPNILRLY 74 Query: 70 DVIHTENKLTLVFEFMD--------NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H ++ L+ E+ L K+ + RT + +L L Sbjct: 75 GYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTAT-------------YITELANAL 121 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 ++CH +++HRD+KP+NLL+ G+LK+ DFG + P + ++ TL Y P+++ Sbjct: 122 SYCHSKRVIHRDIKPENLLLGSAGELKIADFGW--SVHAPSSRRTTLCGTLDYLPPEMIE 179 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLI----FDIMGTPNESLWPSVT 237 G R + +D+WS G + E + GKP F +E K I F E ++ Sbjct: 180 G-RMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLIS 238 Query: 238 KLPKYNPNIQQRPPRDLRQVLQ 259 +L K+NP+ QRP LR+VL+ Sbjct: 239 RLLKHNPS--QRPM--LREVLE 256 >6FDY-U nrPDB Length = 276 Score = 110 bits (275), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 89/291 (30%), Positives = 135/291 (46%), Gaps = 44/291 (15%) Query: 11 EKLGNGTYATVYKGL-NKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKHENIVRL 68 E+LG+GTYATVYK K T VA+K V S + + + EI ++K ++H +IV+L Sbjct: 17 ERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQL 76 Query: 69 YDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 D + + L+ EF DL +++ +R + L + + F QL L F HE Sbjct: 77 KDFQWDSDNIYLIMEFCAGGDLSRFIHTRRI------LPEKVARVFMQQLASALQFLHER 130 Query: 128 KILHRDLKPQNLLIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 I H DLKPQN+L++ ++ LKL DFG A+ P + + Y AP+ ++ R Sbjct: 131 NISHLDLKPQNILLSSLEKPHLKLADFGFAQHMS-PWDEKHVLRGSPLYMAPE-MVCQRQ 188 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 Y +D+WS G IL E + G+P F + E + I Sbjct: 189 YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKI------------------------ 224 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 R R + L+P L + D L LL+ +P R+S + HPW Sbjct: 225 ---RSNRVIELPLRPL----LSRDCRDLLQRLLERDPSRRISFQDFFAHPW 268 >3COM-A nrPDB Length = 314 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 85/294 (28%), Positives = 133/294 (45%), Gaps = 47/294 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F LEKLG G+Y +VYK ++K TG VA+K+V ++S+ I+EIS+M++ ++V Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESD---LQEIIKEISIMQQCDSPHVV 87 Query: 67 RLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPR----GLELNLVKYFQWQLLQGLA 122 + Y L +V E Y + +V + R L + + L+GL Sbjct: 88 KYYGSYFKNTDLWIVME--------YCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLE 139 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 + H + +HRD+K N+L+N G KL DFG+A + ++ + T ++ AP+V+ Sbjct: 140 YLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ- 198 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 Y+ DIWS G EM GKP + D ++ IF Sbjct: 199 EIGYNCVADIWSLGITAIEMAEGKPPYA---DIHPMRAIF-------------------- 235 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 I PP R+ E N DF+ L +P+ R +A Q L HP+ Sbjct: 236 --MIPTNPPPTFRK------PELWSDNFTDFVKQCLVKSPEQRATATQLLQHPF 281 >3H4J-B nrPDB Length = 336 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 65/198 (32%), Positives = 105/198 (53%), Gaps = 9/198 (4%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKELKHENIVRL 68 E LG G++ V + T VALK + +L + REIS +K L+H +I++L Sbjct: 15 ETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKL 74 Query: 69 YDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 YDVI T + +V E+ +L Y+ + G ++FQ Q++ + +CH +K Sbjct: 75 YDVITTPTDIVMVIEYAGGELFDYIVEKKRMTEDEGR-----RFFQ-QIICAIEYCHRHK 128 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYST 188 I+HRDLKP+NLL++ +K+ DFGL+ N + + Y AP+V+ G Sbjct: 129 IVHRDLKPENLLLDDNLNVKIADFGLSNIM-TDGNFLKTSCGSPNYAAPEVINGKLYAGP 187 Query: 189 SIDIWSCGCILAEMITGK 206 +D+WSCG +L M+ G+ Sbjct: 188 EVDVWSCGIVLYVMLVGR 205 >5ES1-A nrPDB Length = 328 Score = 108 bits (271), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 72/216 (33%), Positives = 114/216 (52%), Gaps = 17/216 (7%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA---IREISLMKELKHE 63 ++ L +G G +A V + TG VA+K + D + PS+ RE+ +MK L H Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKII--DKTQLNPSSLQKLFREVRIMKGLNHP 74 Query: 64 NIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 NIV+L++VI TE L LV E+ ++ Y+ S R E F+ Q++ + Sbjct: 75 NIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHG-----RMKEKEARAKFR-QIVSAVH 128 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF--GIPVNTFSSEVVTLWYRAPDVL 180 +CH+ I+HRDLK +NLL++ +K+ DFG + F G ++TF + Y AP++ Sbjct: 129 YCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCG---SPPYAAPELF 185 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEE 216 G + +DIWS G IL +++G F G N +E Sbjct: 186 QGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKE 221 >4CZT-A nrPDB Length = 464 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 89/299 (29%), Positives = 134/299 (44%), Gaps = 55/299 (18%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI----REISLMKELKHENIVRL 68 LG GT+A V N G VA+K + D E+ + I REIS MK +KH N++R+ Sbjct: 19 LGEGTFAKVKFARNVENGDNVAIKVI--DKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 76 Query: 69 YDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 ++V+ ++ K+ V EF+ + D + + R E KYFQ QL+ + +CH Sbjct: 77 FEVMASKTKIYFVLEFVTGG--ELFDK--ISSNGRLKEDEARKYFQ-QLINAVDYCHSRG 131 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLA------RAFGIPVNTFSSEVVTLWYRAPDVLMG 182 + HRDLKP+NLL++ G LK+ DFGL+ R G+ T T Y AP+V+ Sbjct: 132 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG----TPNYVAPEVINN 187 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 D+WSCG IL ++ G F +N K IF T S KL Sbjct: 188 KGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKL--- 244 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 ++++L P NP R++ + + + WF + Y Sbjct: 245 -----------IKRILDP--------------------NPATRITFAEVIENEWFKKGY 272 >3Q53-A nrPDB Length = 306 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 83/292 (28%), Positives = 133/292 (45%), Gaps = 39/292 (13%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 ++ + EK+G G TVY ++ TG VA++++ L ++ I EI +M+E K+ NI Sbjct: 22 KYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNL-QQQPKKELIINEILVMRENKNPNI 80 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 V D ++L +V E++ S T T ++ + + LQ L F H Sbjct: 81 VNYLDSYLVGDELWVVMEYLAGG------SLTDVVTETCMDEGQIAAVCRECLQALEFLH 134 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 N+++HRD+K N+L+ G +KL DFG + S+ V T ++ AP+V+ + Sbjct: 135 SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-RKA 193 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 Y +DIWS G + EMI G+P + N L LI GTP Sbjct: 194 YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIA-TNGTPE---------------- 236 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 Q P E L DFL+ L+++ + R SAK+ + H + Sbjct: 237 -LQNP-------------EKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFL 274 >4B8L-A nrPDB Length = 286 Score = 108 bits (269), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 79/288 (27%), Positives = 123/288 (42%), Gaps = 48/288 (16%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSE---EGTPSTAIREISLMKELKHENIVRLY 69 LG G + VY K +ALK V S+ EG REI + L+H NI+R+Y Sbjct: 23 LGKGKFGNVYLAREKQNKFIMALK-VLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMY 81 Query: 70 DVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 + H ++ L+ EF +L K + + R F +L L +CHE K Sbjct: 82 NYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSAT------FMEELADALHYCHERK 135 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYST 188 ++HRD+KP+NLL+ +G+LK+ DFG + P + TL Y P+++ G +T+ Sbjct: 136 VIHRDIKPENLLMGYKGELKIADFGW--SVHAPSLRRRTMCGTLDYLPPEMIEG-KTHDE 192 Query: 189 SIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQ 248 +D+W G + E + G P F + E + I ++ K P + Sbjct: 193 KVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNV-----------DLKFPPF------ 235 Query: 249 RPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 L D + LL+ +P RL K + HPW Sbjct: 236 -----------------LSDGSKDLISKLLRYHPPQRLPLKGVMEHPW 266 >1KOA-A nrPDB Length = 491 Score = 107 bits (268), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 81/292 (27%), Positives = 132/292 (45%), Gaps = 43/292 (14%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E+LG G + V++ + TG A K V + E T +EI M L+H +V L+D Sbjct: 57 EELGTGAFGVVHRVTERATGNNFAAKFV-MTPHESDKETVRKEIQTMSVLRHPTLVNLHD 115 Query: 71 VIHTENKLTLVFEFMDND--LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 +N++ +++EFM +K D + E V+Y + Q+ +GL HEN Sbjct: 116 AFEDDNEMVMIYEFMSGGELFEKVADEHN-----KMSEDEAVEYMR-QVCKGLCHMHENN 169 Query: 129 ILHRDLKPQNLLIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 +H DLKP+N++ + +LKL DFGL A P + T + AP+V G + Sbjct: 170 YVHLDLKPENIMFTTKRSNELKLIDFGLT-AHLDPKQSVKVTTGTAEFAAPEVAEG-KPV 227 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNI 246 D+WS G + +++G F G ND+E L+ + ++S + +++ Sbjct: 228 GYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISE-------- 279 Query: 247 QQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 DG DF+ LL +P+ R++ QAL HPW Sbjct: 280 --------------------DGK--DFIRKLLLADPNTRMTIHQALEHPWLT 309 >2VN9-A nrPDB Length = 301 Score = 107 bits (268), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 88/309 (28%), Positives = 139/309 (44%), Gaps = 54/309 (17%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-REISLMKEL 60 S + +++ E+LG G ++ V + + TG A K + + RE + + L Sbjct: 1 SMTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 60 Query: 61 KHENIVRLYDVIHTENKLTLVFE-------FMDNDLKKYMDSRTVGNTPRGLELNLVKYF 113 KH NIVRL+D I E LVF+ F D ++Y + + Sbjct: 61 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQ---------- 110 Query: 114 QWQLLQGLAFCHENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVV 170 Q+L+ + CH N I+HRDLKP+NLL+ +K +KL DFGLA + Sbjct: 111 --QILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAG 168 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNE 230 T Y +P+VL Y +D+W+CG IL ++ G P F DE+Q +L I + Sbjct: 169 TPGYLSPEVLRKD-PYGKPVDMWACGVILYILLVGYPPF---WDEDQHRLYQQIKAGAYD 224 Query: 231 SLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 +PS P+++ + P K D ++ +L +NP R++A + Sbjct: 225 --FPS----PEWD-------------TVTPEAK--------DLINKMLTINPAKRITASE 257 Query: 291 ALHHPWFAE 299 AL HPW + Sbjct: 258 ALKHPWICQ 266 >4EQM-A nrPDB Length = 294 Score = 107 bits (267), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 69/212 (32%), Positives = 117/212 (55%), Gaps = 11/212 (5%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKL--DSEEGTPSTAIREISLMKELK 61 + ++K ++KLG G +TVY + + VA+K + + +E T RE+ +L Sbjct: 10 NERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLS 69 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H+NIV + DV ++ LV E+++ L +Y++S L ++ F Q+L G Sbjct: 70 HQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHG------PLSVDTAINFTNQILDG 123 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-TLWYRAPDV 179 + H+ +I+HRD+KPQN+LI+ LK+ DFG+A+A T ++ V+ T+ Y +P+ Sbjct: 124 IKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQ 183 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPG 211 G T + DI+S G +L EM+ G+P F G Sbjct: 184 AKGEATDECT-DIYSIGIVLYEMLVGEPPFNG 214 >3UTO-A nrPDB Length = 573 Score = 107 bits (267), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 81/291 (27%), Positives = 132/291 (45%), Gaps = 43/291 (14%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E+LG G + V++ + TG A K V + E T +EI M L+H +V L+D Sbjct: 163 EELGTGAFGVVHRVTERATGNNFAAKFV-MTPHESDKETVRKEIQTMSVLRHPTLVNLHD 221 Query: 71 VIHTENKLTLVFEFMDND--LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 +N++ +++EFM +K D + E V+Y + Q+ +GL HEN Sbjct: 222 AFEDDNEMVMIYEFMSGGELFEKVADEHN-----KMSEDEAVEYMR-QVCKGLCHMHENN 275 Query: 129 ILHRDLKPQNLLIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 +H DLKP+N++ + +LKL DFGL A P + T + AP+V G + Sbjct: 276 YVHLDLKPENIMFTTKRSNELKLIDFGLT-AHLDPKQSVKVTTGTAEFAAPEVAEG-KPV 333 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNI 246 D+WS G + +++G F G ND+E L+ + ++S + +++ Sbjct: 334 GYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISE-------- 385 Query: 247 QQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 DG DF+ LL +P+ R++ QAL HPW Sbjct: 386 --------------------DGK--DFIRKLLLADPNTRMTIHQALEHPWL 414 >2X4F-A nrPDB Length = 373 Score = 107 bits (267), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 87/300 (29%), Positives = 134/300 (44%), Gaps = 47/300 (15%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKL----DSEEGTPSTAIREISLMKELKHENIV 66 E LG G + V+K TG+ +A K +K D EE EIS+M +L H N++ Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEE-----VKNEISVMNQLDHANLI 149 Query: 67 RLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 +LYD ++N + LV E++D + R + + EL+ + F Q+ +G+ H+ Sbjct: 150 QLYDAFESKNDIVLVMEYVDG---GELFDRIIDESYNLTELDTI-LFMKQICEGIRHMHQ 205 Query: 127 NKILHRDLKPQNLLINKRG--QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 ILH DLKP+N+L R Q+K+ DFGLAR + P T + AP+V+ Sbjct: 206 MYILHLDLKPENILCVNRDAKQIKIIDFGLARRYK-PREKLKVNFGTPEFLAPEVV-NYD 263 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 S D+WS G I +++G F G ND E L I Sbjct: 264 FVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNIL---------------------- 301 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHA 304 R L+ + + +F+ LL R+SA +AL HPW +++ H+ Sbjct: 302 --------ACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHKLHS 353 >5IG1-A nrPDB Length = 344 Score = 107 bits (266), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 81/291 (27%), Positives = 128/291 (43%), Gaps = 43/291 (14%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-REISLMKELKHENIVRLYDV 71 +G G ++TV++ +NK TG A+K + L S + I REI + L+HE+IV + Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRRA 84 Query: 72 IHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 E+ LVFE++ +L + +R N Q+L L CH I+ Sbjct: 85 FRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDA------SACMHQILSALQHCHSKNII 138 Query: 131 HRDLKPQNLLINKR---GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYS 187 HRDLKP+NLL+ + +K+ DFGLA T+ T Y +P+V+ Y Sbjct: 139 HRDLKPENLLLASKDPNAPVKITDFGLA-VIMEQGPTYFGFAGTPGYLSPEVIR-RVPYD 196 Query: 188 TSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQ 247 T++D+W+CG IL ++ G P F + ++ I + W SVT K Sbjct: 197 TAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAK------ 250 Query: 248 QRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + + +L+ NP R + ++ L HPW A Sbjct: 251 ------------------------ELIKAMLEPNPKRRPTVQELLQHPWIA 277 >4FG9-A nrPDB Length = 320 Score = 106 bits (264), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 79/295 (26%), Positives = 134/295 (45%), Gaps = 52/295 (17%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 72 LG G ++ V +K T VA+K + ++ EG + EI+++ ++KH NIV L D+ Sbjct: 26 LGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIY 85 Query: 73 HTENKLTLVF------EFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 + L L+ E D ++K T + R + +Q+L + + H+ Sbjct: 86 ESGGHLYLIMQLVSGGELFDRIVEKGF--YTERDASRLI---------FQVLDAVKYLHD 134 Query: 127 NKILHRDLKPQNLL---INKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 I+HRDLKP+NLL +++ ++ + DFGL++ P + S+ T Y AP+VL Sbjct: 135 LGIVHRDLKPENLLYYSLDEDSKIMISDFGLSK-MEDPGSVLSTACGTPGYVAPEVL-AQ 192 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 + YS ++D WS G I ++ G P F ND + + I + W ++ K Sbjct: 193 KPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAK-- 250 Query: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 DF+ L++ +P+ R + +QAL HPW A Sbjct: 251 ----------------------------DFIRHLMEKDPEKRFTCEQALQHPWIA 277 >4JXF-A nrPDB Length = 266 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 80/295 (27%), Positives = 134/295 (45%), Gaps = 43/295 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKELKHEN 64 FK LG G++A VY+ + TG+ VA+K + K + G E+ + +LKH + Sbjct: 9 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS 68 Query: 65 IVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 I+ LY+ N + LV E N ++ +Y+ +R + N ++F Q++ G+ + Sbjct: 69 ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRV-----KPFSENEARHFMHQIITGMLY 123 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 H + ILHRDL NLL+ + +K+ DFGLA +P + T Y +P++ S Sbjct: 124 LHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRS 183 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 + D+WS GC+ ++ G+P F D + +K T N+ + ++P + Sbjct: 184 -AHGLESDVWSLGCMFYTLLIGRPPF----DTDTVK------NTLNKVVLADY-EMPSF- 230 Query: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 L D +H LL+ NP RLS L HP+ + Sbjct: 231 ----------------------LSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263 >2QNJ-A nrPDB Length = 328 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 68/216 (31%), Positives = 116/216 (53%), Gaps = 17/216 (7%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA---IREISLMKELKHE 63 ++ L+ +G G +A V + TG VA+K + D + P++ RE+ +MK L H Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKII--DKTQLNPTSLQKLFREVRIMKILNHP 71 Query: 64 NIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 NIV+L++VI TE L L+ E+ ++ Y+ + R E F+ Q++ + Sbjct: 72 NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHG-----RMKEKEARSKFR-QIVSAVQ 125 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF--GIPVNTFSSEVVTLWYRAPDVL 180 +CH+ +I+HRDLK +NLL++ +K+ DFG + F G ++TF + Y AP++ Sbjct: 126 YCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCG---SPPYAAPELF 182 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEE 216 G + +D+WS G IL +++G F G N +E Sbjct: 183 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE 218 >3BHH-A nrPDB Length = 295 Score = 105 bits (261), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 88/309 (28%), Positives = 137/309 (44%), Gaps = 54/309 (17%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-REISLMKEL 60 S + +++ E +G G ++ V + + TG A K + + RE + + L Sbjct: 1 SMTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLL 60 Query: 61 KHENIVRLYDVIHTENKLTLVFE-------FMDNDLKKYMDSRTVGNTPRGLELNLVKYF 113 KH NIVRL+D I E LVF+ F D ++Y + + Sbjct: 61 KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQ---------- 110 Query: 114 QWQLLQGLAFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFGIPVNTFSSEVV 170 Q+L+ + CH+ ++HRDLKP+NLL+ K +KL DFGLA + Sbjct: 111 --QILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAG 168 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNE 230 T Y +P+VL Y +DIW+CG IL ++ G P F DE+Q KL I + Sbjct: 169 TPGYLSPEVLR-KEAYGKPVDIWACGVILYILLVGYPPF---WDEDQHKLYQQIKAGAYD 224 Query: 231 SLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 +PS P+++ T P NL++ +L +NP R++A + Sbjct: 225 --FPS----PEWD------------------TVTPEAKNLIN---QMLTINPAKRITAHE 257 Query: 291 ALHHPWFAE 299 AL HPW + Sbjct: 258 ALKHPWVCQ 266 >2XNP-A nrPDB Length = 279 Score = 105 bits (261), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 75/225 (33%), Positives = 111/225 (49%), Gaps = 14/225 (6%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKEL 60 S + ++ L +G G+Y K K+ G + KE+ S E + E++L++EL Sbjct: 3 SRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLREL 62 Query: 61 KHENIVRLYDVI--HTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRG-LELNLVKYFQWQ 116 KH NIVR YD I T L +V E+ + DL + T G R L+ V Q Sbjct: 63 KHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVI---TKGTKERQYLDEEFVLRVMTQ 119 Query: 117 LLQGLAFCHE-----NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVT 171 L L CH + +LHRDLKP N+ ++ + +KLGDFGLAR + + V T Sbjct: 120 LTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGT 179 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEE 216 +Y +P+ M +Y+ DIWS GC+L E+ P F + +E Sbjct: 180 PYYMSPEQ-MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKE 223 >4LG4-A nrPDB Length = 299 Score = 104 bits (259), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 82/295 (27%), Positives = 132/295 (44%), Gaps = 47/295 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F LEKLG G+Y +V+K ++K +G VA+K+V ++S+ I+EIS+M++ +V Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL---QEIIKEISIMQQCDSPYVV 69 Query: 67 RLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVK----YFQWQLLQGLA 122 + Y L +V E Y + +V + R L++ L+GL Sbjct: 70 KYYGSYFKNTDLWIVME--------YCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLE 121 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 + H + +HR++K N+L+N G KL DFG+A + ++ + T ++ AP+V+ Sbjct: 122 YLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ- 180 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 Y+ DIWS G EM GKP + D ++ IF Sbjct: 181 EIGYNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIF-------------------- 217 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 I PP R+ E + DF+ L NP+ R +A Q L HP+ Sbjct: 218 --MIPTNPPPTFRK------PELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 264 >5KZ7-A nrPDB Length = 346 Score = 103 bits (258), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 68/216 (31%), Positives = 112/216 (51%), Gaps = 17/216 (7%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHENI 65 ++ L+ +G G +A V + TG VA+K + K + RE+ +MK L H NI Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 94 Query: 66 VRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 V+L++VI TE L LV E+ ++ Y+ + R E F+ Q++ + +C Sbjct: 95 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHG-----RMKEKEARAKFR-QIVSAVQYC 148 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW----YRAPDVL 180 H+ I+HRDLK +NLL++ +K+ DFG + F TF +++ T Y AP++ Sbjct: 149 HQKFIVHRDLKAENLLLDADMNIKIADFGFSNEF-----TFGNKLDTFCGSPPYAAPELF 203 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEE 216 G + +D+WS G IL +++G F G N +E Sbjct: 204 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE 239 >3IS5-A nrPDB Length = 285 Score = 103 bits (258), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 80/294 (27%), Positives = 131/294 (44%), Gaps = 44/294 (14%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 KLG+G + V+ +++G+ +K + D + EI ++K L H NI+++++V Sbjct: 29 KLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHPNIIKIFEV 88 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELN--LVKYFQWQLLQGLAFCHENKI 129 + + +V E + + R V RG L+ V Q++ LA+ H + Sbjct: 89 FEDYHNMYIVMETCEGG---ELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHSQHV 145 Query: 130 LHRDLKPQNLLINK---RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 +H+DLKP+N+L +K+ DFGLA F ++ ++ T Y AP+V R Sbjct: 146 VHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHS-TNAAGTALYMAPEVF--KRDV 202 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDEE-QLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 + DIWS G ++ ++TG F GT+ EE Q K + K P Y Sbjct: 203 TFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATY---------------KEPNYAVE 247 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + PL +D L +L +P+ R SA Q LHH WF + Sbjct: 248 CR-----------------PLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >2VZ6-A nrPDB Length = 313 Score = 103 bits (257), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 84/305 (27%), Positives = 135/305 (44%), Gaps = 54/305 (17%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-REISLMKELKHE 63 S ++ E+LG G ++ V + + G A K + + RE + + LKH Sbjct: 22 SMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 81 Query: 64 NIVRLYDVIHTENKLTLVFE-------FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 NIVRL+D I E L+F+ F D ++Y + + Q Sbjct: 82 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQ------------Q 129 Query: 117 LLQGLAFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFGIPVNTFSSEVVTLW 173 +L+ + CH+ ++HRDLKP+NLL+ K +KL DFGLA + T Sbjct: 130 ILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPG 189 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 Y +P+VL Y +D+W+CG IL ++ G P F DE+Q +L I + + Sbjct: 190 YLSPEVLRKD-PYGKPVDLWACGVILYILLVGYPPF---WDEDQHRLYQQIKAGAYD--F 243 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 PS P+++ + P K D ++ +L +NP R++A +AL Sbjct: 244 PS----PEWD-------------TVTPEAK--------DLINKMLTINPSKRITAAEALK 278 Query: 294 HPWFA 298 HPW + Sbjct: 279 HPWIS 283 >6AO5-A nrPDB Length = 362 Score = 103 bits (256), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 82/295 (27%), Positives = 132/295 (44%), Gaps = 47/295 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F LEKLG G+Y +V+K ++K +G VA+K+V ++S+ I+EIS+M++ +V Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD---LQEIIKEISIMQQCDSPYVV 68 Query: 67 RLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVK----YFQWQLLQGLA 122 + Y L +V E Y + +V + R L++ L+GL Sbjct: 69 KYYGSYFKNTDLWIVME--------YCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLE 120 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 + H + +HR++K N+L+N G KL DFG+A + ++ + T ++ AP+V+ Sbjct: 121 YLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ- 179 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 Y+ DIWS G EM GKP + D ++ IF Sbjct: 180 EIGYNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIF-------------------- 216 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 I PP R+ E + DF+ L NP+ R +A Q L HP+ Sbjct: 217 --MIPTNPPPTFRK------PELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 263 >4YZB-A nrPDB Length = 491 Score = 103 bits (256), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 90/300 (30%), Positives = 146/300 (48%), Gaps = 45/300 (15%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKELK 61 S ++K LG G++ V +K TG A+K + + ++ ++E+ L+K+L Sbjct: 29 SDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLD 88 Query: 62 HENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H NI++LY+ + LV E + +L + SR R E++ + + Q+L G Sbjct: 89 HPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISR-----KRFSEVDAARIIR-QVLSG 142 Query: 121 LAFCHENKILHRDLKPQNLLI-NKR--GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + + H+NKI+HRDLKP+NLL+ NKR +++ DFGL+ F ++ T +Y AP Sbjct: 143 ITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFE-STKKMKDKIGTAYYIAP 201 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +VL G TY D+WS G IL +++G P F G N+ + LK + T + W V+ Sbjct: 202 EVLHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVS 259 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + P +DL + +L P MR+SA+ AL H W Sbjct: 260 E-----------PAKDL-------------------IRKMLAYVPTMRISARDALEHEWL 289 >2Y7J-A nrPDB Length = 365 Score = 103 bits (256), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 76/299 (25%), Positives = 133/299 (44%), Gaps = 51/299 (17%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPS-------TAIREISLMKELK-HEN 64 +G G + V + +++ TG A+K +++ +E +P RE +++++ H + Sbjct: 102 IGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPH 161 Query: 65 IVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 I+ L D + + + LVF+ M +L Y+ + L + LL+ ++F Sbjct: 162 IITLIDSYESSSFMFLVFDLMRKGELFDYLTEKV------ALSEKETRSIMRSLLEAVSF 215 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 H N I+HRDLKP+N+L++ Q++L DFG + P T Y AP++L S Sbjct: 216 LHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLE-PGEKLRELCGTPGYLAPEILKCS 274 Query: 184 RT-----YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 Y +D+W+CG IL ++ G P F L++I + + W + Sbjct: 275 MDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSS 334 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 K D + LLQ++P+ RL+A+QAL HP+F Sbjct: 335 TVK------------------------------DLISRLLQVDPEARLTAEQALQHPFF 363 >4JDH-A nrPDB Length = 346 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 76/294 (25%), Positives = 137/294 (46%), Gaps = 39/294 (13%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 K+G G+ V +++G VA+K++ L ++ E+ +M++ +HEN+V +Y+ Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYQHENVVEMYNS 139 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 ++L +V EF++ + + T N + + L +LQ L+ H ++H Sbjct: 140 YLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLA------VLQALSVLHAQGVIH 193 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSID 191 RD+K ++L+ G++KL DFG V S V T ++ AP+ L+ Y +D Sbjct: 194 RDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVD 252 Query: 192 IWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPP 251 IWS G ++ EM+ G+P + + +K+I D +L P + L K +P+++ Sbjct: 253 IWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-------NLPPRLKNLHKVSPSLK---- 301 Query: 252 RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 FL LL +P R +A + L HP+ A+ AS Sbjct: 302 --------------------GFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 335 >6CQF-A nrPDB Length = 297 Score = 102 bits (254), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 71/220 (32%), Positives = 115/220 (52%), Gaps = 13/220 (5%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 + L++LG GTY V+K +K +G VALK VK++ ++ ST +EI ++K +H NI Sbjct: 17 HYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDV-STLQKEILILKTCRHANI 75 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 V + KL + EF D V + L+++ Y ++LQGLA+ H Sbjct: 76 VAYHGSYLWLQKLWICMEFCGAG--SLQDIYQVTGSLSELQIS---YVCREVLQGLAYLH 130 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS-- 183 K +HRD+K N+LIN G+++L DFG++ G + + + T ++ AP+V + Sbjct: 131 SQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALK 190 Query: 184 RTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIF 222 Y+ DIWS G E+ + PLF D L+++F Sbjct: 191 GGYNELCDIWSLGITAIELAELQPPLF----DVHPLRVLF 226 >4AN9-A nrPDB Length = 301 Score = 102 bits (254), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 63/203 (31%), Positives = 112/203 (55%), Gaps = 13/203 (6%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F+++ +LG G V+K +K +G+ +A K + L+ + + IRE+ ++ E IV Sbjct: 11 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 70 Query: 67 RLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 Y +++ ++++ E MD L + + + G P ++ +++GL + Sbjct: 71 GFYGAFYSDGEISICMEHMDGGSLDQVL--KKAGRIPE----QILGKVSIAVIKGLTYLR 124 Query: 126 E-NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-TLWYRAPDVLMGS 183 E +KI+HRD+KP N+L+N RG++KL DFG++ G ++ ++E V T Y +P+ L G+ Sbjct: 125 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDEMANEFVGTRSYMSPERLQGT 181 Query: 184 RTYSTSIDIWSCGCILAEMITGK 206 YS DIWS G L EM G+ Sbjct: 182 H-YSVQSDIWSMGLSLVEMAVGR 203 >4FIE-A nrPDB Length = 423 Score = 102 bits (254), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 76/294 (25%), Positives = 137/294 (46%), Gaps = 39/294 (13%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 K+G G+ V +++G VA+K++ L ++ E+ +M++ +HEN+V +Y+ Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYQHENVVEMYNS 216 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 ++L +V EF++ + + T N + + L +LQ L+ H ++H Sbjct: 217 YLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLA------VLQALSVLHAQGVIH 270 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSID 191 RD+K ++L+ G++KL DFG V S V T ++ AP+ L+ Y +D Sbjct: 271 RDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVD 329 Query: 192 IWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPP 251 IWS G ++ EM+ G+P + + +K+I D +L P + L K +P+++ Sbjct: 330 IWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-------NLPPRLKNLHKVSPSLK---- 378 Query: 252 RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 FL LL +P R +A + L HP+ A+ AS Sbjct: 379 --------------------GFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 412 >2Q0N-A nrPDB Length = 301 Score = 102 bits (254), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 76/294 (25%), Positives = 137/294 (46%), Gaps = 39/294 (13%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 K+G G+ V +++G VA+K++ L ++ E+ +M++ +HEN+V +Y+ Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYQHENVVEMYNS 94 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 ++L +V EF++ + + T N + + L +LQ L+ H ++H Sbjct: 95 YLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLA------VLQALSVLHAQGVIH 148 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSID 191 RD+K ++L+ G++KL DFG V S V T ++ AP+ L+ Y +D Sbjct: 149 RDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVD 207 Query: 192 IWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPP 251 IWS G ++ EM+ G+P + + +K+I D +L P + L K +P+++ Sbjct: 208 IWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-------NLPPRLKNLHKVSPSLK---- 256 Query: 252 RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 FL LL +P R +A + L HP+ A+ AS Sbjct: 257 --------------------GFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 290 >4XBR-A nrPDB Length = 366 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 76/294 (25%), Positives = 137/294 (46%), Gaps = 39/294 (13%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 K+G G+ V +++G VA+K++ L ++ E+ +M++ +HEN+V +Y+ Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-ELLFNEVVIMRDYQHENVVEMYNS 159 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 ++L +V EF++ + + T N + + L +LQ L+ H ++H Sbjct: 160 YLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLA------VLQALSVLHAQGVIH 213 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSID 191 RD+K ++L+ G++KL DFG V S V T ++ AP+ L+ Y +D Sbjct: 214 RDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVD 272 Query: 192 IWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPP 251 IWS G ++ EM+ G+P + + +K+I D +L P + L K +P+++ Sbjct: 273 IWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-------NLPPRLKNLHKVSPSLK---- 321 Query: 252 RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 FL LL +P R +A + L HP+ A+ AS Sbjct: 322 --------------------GFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 355 >4D2V-A nrPDB Length = 356 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 83/295 (28%), Positives = 136/295 (46%), Gaps = 42/295 (14%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E +G G +A V + TG VA+K + ++ EI +K L+H++I +LY Sbjct: 35 ETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYH 94 Query: 71 VIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 V+ T NK+ +V E+ +L Y+ S+ R E F+ Q++ +A+ H Sbjct: 95 VLETANKIFMVLEYCPGGELFDYIISQD-----RLSEEETRVVFR-QIVSAVAYVHSQGY 148 Query: 130 LHRDLKPQNLLINKRGQLKLGDFGL-ARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYST 188 HRDLKP+NLL ++ +LKL DFGL A+ G + L Y AP+++ G + Sbjct: 149 AHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYLGS 208 Query: 189 SIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQ 248 D+WS G +L ++ G F +D+ L+ IM Sbjct: 209 EADVWSMGILLYVLMCG---FLPFDDDTAAALVAKIM----------------------- 242 Query: 249 RPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHH 303 R D+ + L P + + L +LQ++P R+S K L+HPW + Y++ Sbjct: 243 RGKYDVPKWLSPSS--------ILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNY 289 >5U6Y-A nrPDB Length = 461 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 83/303 (27%), Positives = 134/303 (44%), Gaps = 54/303 (17%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-REISLMKELKHENI 65 ++ E+LG G ++ V + + G A K + + RE + + LKH NI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 66 VRLYDVIHTENKLTLVFE-------FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 VRL+D I E L+F+ F D ++Y + + Q+L Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQ------------QIL 109 Query: 119 QGLAFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 + + CH+ ++HRDLKP+NLL+ K +KL DFGLA + T Y Sbjct: 110 EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL 169 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 +P+VL Y +D+W+CG IL ++ G P F DE+Q +L I + +PS Sbjct: 170 SPEVLRKD-PYGKPVDLWACGVILYILLVGYPPFW---DEDQHRLYQQIKAGAYD--FPS 223 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 P+++ + P K D ++ +L +NP R++A +AL HP Sbjct: 224 ----PEWD-------------TVTPEAK--------DLINKMLTINPSKRITAAEALKHP 258 Query: 296 WFA 298 W + Sbjct: 259 WIS 261 >2HAK-A nrPDB Length = 328 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 68/210 (32%), Positives = 111/210 (52%), Gaps = 17/210 (8%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA---IREISLMKELKHENIVRLY 69 +G G +A V + TG VA+K + D + P++ RE+ +MK L H NIV+L+ Sbjct: 23 IGKGNFAKVKLARHVLTGREVAVKII--DKTQLNPTSLQKLFREVRIMKILNHPNIVKLF 80 Query: 70 DVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 +VI TE L LV E+ ++ Y+ + R E F+ Q++ + +CH+ Sbjct: 81 EVIETEKTLYLVMEYASGGEVFDYLVAHG-----RMKEKEARAKFR-QIVSAVQYCHQKY 134 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAF--GIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 I+HRDLK +NLL++ +K+ DFG + F G ++TF + Y AP++ G + Sbjct: 135 IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCG---SPPYAAPELFQGKKYD 191 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDEE 216 +D+WS G IL +++G F G N +E Sbjct: 192 GPEVDVWSLGVILYTLVSGSLPFDGQNLKE 221 >5JZN-A nrPDB Length = 280 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 83/303 (27%), Positives = 135/303 (44%), Gaps = 53/303 (17%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 + ++K +G+G +A V + + ++T ALK +K G E+S+++ +KH Sbjct: 18 TERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHP 77 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGN--TPRGLELNLVKYFQWQLLQGL 121 NIV L + + +L LV E + D+ T N T R L + L + Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKG--GDLFDAITSTNKYTERDASGML-----YNLASAI 130 Query: 122 AFCHENKILHRDLKPQNLLI----NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + H I+HRD+KP+NLL+ + LKLGDFGLA P+ T T Y AP Sbjct: 131 KYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCG---TPTYVAP 187 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFD--IMGTPN--ESLW 233 +++ Y +DIW+ G I ++ G P F G+ D+++ ++FD +MG + W Sbjct: 188 EII-AETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQE--VLFDQILMGQVDFPSPYW 244 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 +V+ K + + +L ++ D R SA Q L Sbjct: 245 DNVSDSAK------------------------------ELITMMLLVDVDQRFSAVQVLE 274 Query: 294 HPW 296 HPW Sbjct: 275 HPW 277 >4YNZ-A nrPDB Length = 342 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 77/292 (26%), Positives = 138/292 (47%), Gaps = 44/292 (15%) Query: 9 QLEK-LGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKHENIV 66 +LEK LG G V G++ T VA+K V + E REI+++K ++H +++ Sbjct: 13 RLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVL 72 Query: 67 RLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 +L+DV + L LV E + +L Y+ + TP+ K+F+ Q++ L FCH Sbjct: 73 KLHDVYENKKYLYLVLEHVSGGELFDYLVKKG-RLTPKEAR----KFFR-QIISALDFCH 126 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 + I HRDLKP+NLL+++R +++ DFG+A + + + + + Y P+V+ G + Sbjct: 127 SHSICHRDLKPENLLLDERNNIRIADFGMA-SLQVGDSLLETSCGSPHYACPEVIRGEKY 185 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 D+WSCG IL ++ G F D++ L+ + E + V +P + P Sbjct: 186 DGRKADVWSCGVILFALLVGALPF----DDDNLRQLL-------EKVKRGVFHMPHFIPP 234 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + L G+++++ RL+ + H W+ Sbjct: 235 -----------------------DCQSLLRGMIEVDAARRLTLEHIQKHIWY 263 >4CQG-A nrPDB Length = 331 Score = 101 bits (251), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 84/297 (28%), Positives = 138/297 (46%), Gaps = 42/297 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 ++ E +G G +A V + TG VA+K + ++ EI +K L+H++I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHIC 70 Query: 67 RLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 +LY V+ T+NK+ +V E+ +L Y+ S+ R E F+ Q+L +A+ H Sbjct: 71 QLYHVLETKNKIFMVLEYCPGGELFDYIISQD-----RLSEEETRVVFR-QILSAVAYVH 124 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGL-ARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 HRDLKP+NLL ++ +LKL DFGL A+ G +L Y AP+++ G Sbjct: 125 SQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKS 184 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 + D+WS G +L ++ G F +D+ + L IM E +PK+ Sbjct: 185 YLGSEADVWSMGILLYVLMCG---FLPFDDDNVMALYKKIMRGKYE--------VPKW-- 231 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 L P + + L +LQ++P R+S + L+HPW + Y Sbjct: 232 -------------LSPSS--------ILLLQQMLQVDPKKRISMRNLLNHPWVMQDY 267 >2V7O-A nrPDB Length = 336 Score = 101 bits (251), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 89/307 (28%), Positives = 135/307 (43%), Gaps = 54/307 (17%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-REISLMKELKH 62 + ++ E+LG G ++ V + + KT A K + + RE + + LKH Sbjct: 30 TDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKH 89 Query: 63 ENIVRLYDVIHTENKLTLVFE-------FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 NIVRL+D I E LVF+ F D ++Y + Sbjct: 90 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIH------------ 137 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFGIPVNTFSSEVVTL 172 Q+L+ + H++ I+HRDLKP+NLL+ K +KL DFGLA + T Sbjct: 138 QILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTP 197 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESL 232 Y +P+VL Y +DIW+CG IL ++ G P F DE+Q KL I + Sbjct: 198 GYLSPEVLRKD-PYGKPVDIWACGVILYILLVGYPPF---WDEDQHKLYQQIKAGAYD-- 251 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 +PS P+++ T P NL++ +L +NP R++A QAL Sbjct: 252 FPS----PEWD------------------TVTPEAKNLIN---QMLTINPAKRITADQAL 286 Query: 293 HHPWFAE 299 HPW + Sbjct: 287 KHPWVCQ 293 >3D2K-A nrPDB Length = 272 Score = 101 bits (251), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 74/295 (25%), Positives = 125/295 (42%), Gaps = 62/295 (21%) Query: 13 LGNGTYATVYKGLNKTTGVYVALK---EVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 LG G + VY + + +ALK + +L+ + G RE+ + L+H NI+RLY Sbjct: 20 LGKGKFGNVYLARERQSKFILALKVLFKTQLE-KAGVEHQLRREVEIQSHLRHPNILRLY 78 Query: 70 DVIHTENKLTLVFEFMD--------NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H ++ L+ E+ L ++ + RT + +L L Sbjct: 79 GYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTAT-------------YITELANAL 125 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 ++CH +++HRD+KP+NLL+ G+LK+ DFG + P + ++ TL Y P+++ Sbjct: 126 SYCHSKRVIHRDIKPENLLLGSNGELKIADFGW--SVHAPSSRRTTLCGTLDYLPPEMIE 183 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 G R + +D+WS G + E + G P F +E + I + T Sbjct: 184 G-RMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFT-------------- 228 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 P+ RDL + LL+ N RL+ + L HPW Sbjct: 229 -FPDFVTEGARDL-------------------ISRLLKHNASQRLTLAEVLEHPW 263 >3HKO-A nrPDB Length = 345 Score = 100 bits (250), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 89/334 (26%), Positives = 135/334 (40%), Gaps = 76/334 (22%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIR---EISLMKELKHENIVRL 68 +G G+Y V + T A+K + + + P R E+ LMK+L H NI RL Sbjct: 34 IGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPNIARL 93 Query: 69 YDVIHTENKLTLVFE-------------FMDNDLKKY--------------MDSRTVGNT 101 Y+V E + LV E F+D+ K + + + Sbjct: 94 YEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAINGS 153 Query: 102 PRGLELNL--------VKYFQWQLLQGLAFCHENKILHRDLKPQNLLI--NKRGQLKLGD 151 G +L + Q+ L + H I HRD+KP+N L NK ++KL D Sbjct: 154 IHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKLVD 213 Query: 152 FGLARAFGIPVNT----FSSEVVTLWYRAPDVL-MGSRTYSTSIDIWSCGCILAEMITGK 206 FGL++ F N +++ T ++ AP+VL + +Y D WS G +L ++ G Sbjct: 214 FGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLHLLLMGA 273 Query: 207 PLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPL 266 FPG ND + + + + KL NPN VL P + Sbjct: 274 VPFPGVNDADTISQVLN-------------KKLCFENPNYN---------VLSPLAR--- 308 Query: 267 DGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 D L LL N D R A +AL HPW +++ Sbjct: 309 -----DLLSNLLNRNVDERFDAMRALQHPWISQF 337 >5EZV-A nrPDB Length = 560 Score = 100 bits (250), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 80/295 (27%), Positives = 134/295 (45%), Gaps = 50/295 (16%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-----REISLMKELKHENI 65 + LG GT+ V G ++ TG VA VK+ + + S + REI +K +H +I Sbjct: 34 DTLGVGTFGKVKIGEHQLTGHKVA---VKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 90 Query: 66 VRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 ++LY VI T +V E++ +L Y + R E+ + FQ Q+L + +C Sbjct: 91 IKLYQVISTPTDFFMVMEYVSGGELFDY-----ICKHGRVEEMEARRLFQ-QILSAVDYC 144 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 H + ++HRDLKP+N+L++ K+ DFGL+ + + Y AP+V+ G Sbjct: 145 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRL 203 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 +DIWSCG IL ++ G F D+E + +F + + V +P+Y Sbjct: 204 YAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLF-------KKIRGGVFYIPEY-- 250 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 L+ ++ L +LQ++P R + K H WF + Sbjct: 251 ---------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 284 >6HXF-B nrPDB Length = 302 Score = 100 bits (250), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 84/293 (28%), Positives = 126/293 (43%), Gaps = 44/293 (15%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 +LG+G + VYK NK TG A K ++ SEE I EI ++ H IV+L Sbjct: 26 ELGDGAFGKVYKAKNKETGALAAAKVIETKSEEEL-EDYIVEIEILATCDHPYIVKLLGA 84 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 + + KL ++ EF +D+ + RGL ++ Q+L+ L F H +I+H Sbjct: 85 YYHDGKLWIMIEFCPGGA---VDAIML-ELDRGLTEPQIQVVCRQMLEALNFLHSKRIIH 140 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT----YS 187 RDLK N+L+ G ++L DFG++ + S + T ++ AP+V+M Y Sbjct: 141 RDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYD 200 Query: 188 TSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP--SVTKLPKYNPN 245 DIWS G L EM +P P+ L P + K+ K +P Sbjct: 201 YKADIWSLGITLIEMAQIEP--------------------PHHELNPMRVLLKIAKSDPP 240 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 P + DFL L NP+ R SA Q L HP+ + Sbjct: 241 TLLTPSK-------------WSVEFRDFLKIALDKNPETRPSAAQLLEHPFVS 280 >4CFF-A nrPDB Length = 571 Score = 100 bits (250), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 80/295 (27%), Positives = 134/295 (45%), Gaps = 50/295 (16%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-----REISLMKELKHENI 65 + LG GT+ V G ++ TG VA VK+ + + S + REI +K +H +I Sbjct: 39 DTLGVGTFGKVKIGEHQLTGHKVA---VKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 95 Query: 66 VRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 ++LY VI T +V E++ +L Y + R E+ + FQ Q+L + +C Sbjct: 96 IKLYQVISTPTDFFMVMEYVSGGELFDY-----ICKHGRVEEMEARRLFQ-QILSAVDYC 149 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 H + ++HRDLKP+N+L++ K+ DFGL+ + + Y AP+V+ G Sbjct: 150 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRL 208 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 +DIWSCG IL ++ G F D+E + +F + + V +P+Y Sbjct: 209 YAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLF-------KKIRGGVFYIPEY-- 255 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 L+ ++ L +LQ++P R + K H WF + Sbjct: 256 ---------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 289 >6C9D-A nrPDB Length = 459 Score = 100 bits (249), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 66/208 (31%), Positives = 108/208 (51%), Gaps = 13/208 (6%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA---IREISLMKELKHENIVRLY 69 +G G +A V + TG VA+K + D + P++ RE+ +MK L H NIV+L+ Sbjct: 29 IGKGNFAKVKLARHVLTGREVAVKII--DKTQLNPTSLQKLFREVRIMKILNHPNIVKLF 86 Query: 70 DVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 +VI TE L LV E+ ++ Y+ + R E F+ Q++ + +CH+ Sbjct: 87 EVIETEKTLYLVMEYASGGEVFDYLVAHG-----RMKEKEARAKFR-QIVSAVQYCHQKY 140 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYST 188 I+HRDLK +NLL++ +K+ DFG + F + N + Y AP++ G + Sbjct: 141 IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVG-NKLDEFCGSPPYAAPELFQGKKYDGP 199 Query: 189 SIDIWSCGCILAEMITGKPLFPGTNDEE 216 +D+WS G IL +++G F G N +E Sbjct: 200 EVDVWSLGVILYTLVSGSLPFDGQNLKE 227 >2BRG-A nrPDB Length = 297 Score = 100 bits (249), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 63/199 (31%), Positives = 97/199 (48%), Gaps = 7/199 (3%) Query: 10 LEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 ++ LG G Y V +N+ T VA+K V + P +EI + K L HEN+V+ Y Sbjct: 12 VQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFY 71 Query: 70 DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 N L E+ +G E + ++F QL+ G+ + H I Sbjct: 72 GHRREGNIQYLFLEYCSGGELFDRIEPDIGMP----EPDAQRFFH-QLMAGVVYLHGIGI 126 Query: 130 LHRDLKPQNLLINKRGQLKLGDFGLARAFGI--PVNTFSSEVVTLWYRAPDVLMGSRTYS 187 HRD+KP+NLL+++R LK+ DFGLA F + TL Y AP++L ++ Sbjct: 127 THRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHA 186 Query: 188 TSIDIWSCGCILAEMITGK 206 +D+WSCG +L M+ G+ Sbjct: 187 EPVDVWSCGIVLTAMLAGE 205 >5D7A-A nrPDB Length = 308 Score = 100 bits (249), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 70/214 (32%), Positives = 110/214 (51%), Gaps = 20/214 (9%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALK--EVKLDSEEGTPSTAIREISLMKELKH-E 63 F+ +E +GNGTY VYKG + TG A+K +V D EE +EI+++K+ H Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK----QEINMLKKYSHHR 74 Query: 64 NIVRLYDVIHTEN------KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 NI Y +N +L LV EF + T GNT L+ + Y ++ Sbjct: 75 NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT---LKEEWIAYICREI 131 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 L+GL+ H++K++HRD+K QN+L+ + ++KL DFG++ V ++ + T ++ AP Sbjct: 132 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 191 Query: 178 DVLMGSR----TYSTSIDIWSCGCILAEMITGKP 207 +V+ TY D+WS G EM G P Sbjct: 192 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAP 225 >1S9I-A nrPDB Length = 354 Score = 100 bits (249), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 67/219 (30%), Positives = 121/219 (55%), Gaps = 14/219 (6%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F+++ +LG G V K ++ +G+ +A K + L+ + + IRE+ ++ E IV Sbjct: 18 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 77 Query: 67 RLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 Y +++ ++++ E MD +D V + + ++ +L+GLA+ E Sbjct: 78 GFYGAFYSDGEISICMEHMDGG---SLDQ--VLKEAKRIPEEILGKVSIAVLRGLAYLRE 132 Query: 127 -NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-TLWYRAPDVLMGSR 184 ++I+HRD+KP N+L+N RG++KL DFG++ G +++ ++ V T Y AP+ L G+ Sbjct: 133 KHQIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMAPERLQGTH 189 Query: 185 TYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIF 222 YS DIWS G L E+ G+ P+ P D ++L+ IF Sbjct: 190 -YSVQSDIWSMGLSLVELAVGRYPIPP--PDAKELEAIF 225 >4APC-A nrPDB Length = 350 Score = 100 bits (248), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 66/226 (29%), Positives = 116/226 (51%), Gaps = 16/226 (7%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV---KLDSEEGTPSTAIREISLMKE 59 S ++ +L+K+G G++ + G +KE+ ++ S+E S RE++++ Sbjct: 22 SMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESR--REVAVLAN 79 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQW--Q 116 +KH NIV+ + L +V ++ + DL K + N +G+ + W Q Sbjct: 80 MKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRI------NAQKGVLFQEDQILDWFVQ 133 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 + L H+ KILHRD+K QN+ + K G ++LGDFG+AR V + + T +Y + Sbjct: 134 ICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLS 193 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLF-PGTNDEEQLKLI 221 P++ ++ Y+ DIW+ GC+L E+ T K F G+ LK+I Sbjct: 194 PEICE-NKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKII 238 >4U41-A nrPDB Length = 332 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 68/212 (32%), Positives = 107/212 (50%), Gaps = 16/212 (7%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH-ENI 65 F+ +E +GNGTY VYKG + TG A+K +D E EI+++K+ H NI Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIK--VMDVTEDEEEEIKLEINMLKKYSHHRNI 83 Query: 66 VRLYDVI------HTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 Y +++L LV EF + T GNT L+ + + Y ++L+ Sbjct: 84 ATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNT---LKEDWIAYISREILR 140 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 GLA H + ++HRD+K QN+L+ + ++KL DFG++ V ++ + T ++ AP+V Sbjct: 141 GLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEV 200 Query: 180 LMGSR----TYSTSIDIWSCGCILAEMITGKP 207 + TY D+WSCG EM G P Sbjct: 201 IACDENPDATYDYRSDLWSCGITAIEMAEGAP 232 >2YZA-A nrPDB Length = 276 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 80/293 (27%), Positives = 133/293 (45%), Gaps = 46/293 (15%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEV---KLDSEEGTPSTAIREISLMKELKHENIVR 67 + LG GT+ V G ++ TG VA+K + K+ S + REI +K +H +I++ Sbjct: 17 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK-REIQNLKLFRHPHIIK 75 Query: 68 LYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 LY VI T +V E++ +L Y + R E+ + FQ Q+L + +CH Sbjct: 76 LYQVISTPTDFFMVMEYVSGGELFDY-----ICKHGRVEEMEARRLFQ-QILSAVDYCHR 129 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 + ++HRDLKP+N+L++ K+ DFGL+ + Y AP+V+ G Sbjct: 130 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRDSCGSPNYAAPEVISGRLYA 188 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNI 246 +DIWSCG IL ++ G F D+E + +F + + V +P+Y Sbjct: 189 GPEVDIWSCGVILYALLCGTLPF----DDEHVPTLF-------KKIRGGVFYIPEY---- 233 Query: 247 QQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 L+ ++ L +LQ++P R + K H WF + Sbjct: 234 -------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 267 >3SOA-A nrPDB Length = 444 Score = 99.0 bits (245), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 81/306 (26%), Positives = 135/306 (44%), Gaps = 54/306 (17%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-REISLMKELKH 62 + +++ E+LG G ++ V + + G A + + RE + + LKH Sbjct: 10 TEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH 69 Query: 63 ENIVRLYDVIHTENKLTLVFE-------FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 NIVRL+D I E L+F+ F D ++Y + + Sbjct: 70 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQ------------ 117 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFGIPVNTFSSEVVTL 172 Q+L+ + CH+ ++HR+LKP+NLL+ K +KL DFGLA + T Sbjct: 118 QILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTP 177 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESL 232 Y +P+VL Y +D+W+CG IL ++ G P F DE+Q +L I + Sbjct: 178 GYLSPEVLRKD-PYGKPVDLWACGVILYILLVGYPPF---WDEDQHRLYQQIKAGAYD-- 231 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 +PS P+++ + P K D ++ +L +NP R++A +AL Sbjct: 232 FPS----PEWD-------------TVTPEAK--------DLINKMLTINPSKRITAAEAL 266 Query: 293 HHPWFA 298 HPW + Sbjct: 267 KHPWIS 272 >4I6B-A nrPDB Length = 308 Score = 98.6 bits (244), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 72/259 (27%), Positives = 125/259 (48%), Gaps = 16/259 (6%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKE 59 ++ ++ + + LG G +A Y+ + T A K + S+ +EI L + Sbjct: 25 TTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRI 84 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 L H+++V+ Y + + ++ E+ + + +R V P V+Y+ Q++ Sbjct: 85 LHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPE------VRYYLRQIV 138 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 GL + HE +ILHRDLK N IN+ +LK+GDFGLA + + T Y +P+ Sbjct: 139 SGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPE 198 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGT-PNESLWPS-- 235 VL + + DIW+ GC++ M+ G+P F TN +E + I + T P+ L P+ Sbjct: 199 VL-NKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKH 257 Query: 236 -VTKLPKYNPNIQQRPPRD 253 + + NP + RP D Sbjct: 258 LIASMLSKNP--EDRPSLD 274 >2JAM-A nrPDB Length = 304 Score = 98.6 bits (244), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 84/296 (28%), Positives = 137/296 (46%), Gaps = 48/296 (16%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F +E LG+G ++ V+ + TG ALK +K S S+ EI+++K++KHENIV Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIK-KSPAFRDSSLENEIAVLKKIKHENIV 69 Query: 67 RLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 L D+ + LV + + +L + R V T + L + Q+L + + H Sbjct: 70 TLEDIYESTTHYYLVMQLVSGGELFDRILERGV-YTEKDASLVI-----QQVLSAVKYLH 123 Query: 126 ENKILHRDLKPQNLLI---NKRGQLKLGDFGLAR--AFGIPVNTFSSEVVTLWYRAPDVL 180 EN I+HRDLKP+NLL + ++ + DFGL++ GI S+ T Y AP+VL Sbjct: 124 ENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGI----MSTACGTPGYVAPEVL 179 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 + YS ++D WS G I ++ G P F + + + I + W +++ Sbjct: 180 -AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESA 238 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 K DF+ LL+ +P+ R + ++AL HPW Sbjct: 239 K------------------------------DFICHLLEKDPNERYTCEKALSHPW 264 >4REW-A nrPDB Length = 540 Score = 98.2 bits (243), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 79/295 (26%), Positives = 135/295 (45%), Gaps = 50/295 (16%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-----REISLMKELKHENI 65 + LG GT+ V G ++ TG VA VK+ + + S + REI +K +H +I Sbjct: 12 DTLGVGTFGKVKVGKHELTGHKVA---VKILNRQKIRSLDVVGKIRREIQNLKLFRHPHI 68 Query: 66 VRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 ++LY VI T + + +V E++ +L Y + R E + FQ Q+L G+ +C Sbjct: 69 IKLYQVISTPSDIFMVMEYVSGGELFDY-----ICKNGRLDEKESRRLFQ-QILSGVDYC 122 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 H + ++HRDLKP+N+L++ K+ DFGL+ + + Y AP+V+ G Sbjct: 123 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRL 181 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 +DIWS G IL ++ G F D++ + +F + + + P+Y Sbjct: 182 YAGPEVDIWSSGVILYALLCGTLPF----DDDHVPTLF-------KKICDGIFYTPQY-- 228 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 L+ +++ L +LQ++P R S K H WF + Sbjct: 229 ---------------------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ 262 >6CTH-A nrPDB Length = 309 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 71/230 (30%), Positives = 120/230 (52%), Gaps = 25/230 (10%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 +S F KLG G + +VY+G + + Y+A+K+V S++G A E+ ++ L+H+ Sbjct: 14 TSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYA-SEVKIISRLRHK 72 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA- 122 N+V+L H +L LV+EFM N +DS +G L L ++++++ LA Sbjct: 73 NLVKLIGWCHERGELMLVYEFMANG---SLDSHIF----KGKSL-LTWEVRYRIVKDLAS 124 Query: 123 ---FCHENK---ILHRDLKPQNLLINKRGQLKLGDFGLAR----AFGIPVNTFSSEVVTL 172 + HE +LHRD+K N++++ KLGDFGLAR A G+ + T+ Sbjct: 125 ALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAG---TV 181 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITG-KPLFPGTNDEEQLKLI 221 Y AP+ L + S D++S G + E+ +G + + P + E L L+ Sbjct: 182 GYMAPECLSSGKASKES-DVYSFGVVALEIASGRRSIEPKFEESEALLLV 230 >2PL0-A nrPDB Length = 289 Score = 97.8 bits (242), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 70/221 (31%), Positives = 122/221 (55%), Gaps = 22/221 (9%) Query: 7 FKQLEKLGNGTYATVYKGL-NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 K +E+LG G + V+ G N T V A+K +K S +P + E +LMK+L+H+ + Sbjct: 25 LKLVERLGAGQFGEVWMGYYNGHTKV--AVKSLKQGSM--SPDAFLAEANLMKQLQHQRL 80 Query: 66 VRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQW--QLLQGLA 122 VRLY V+ T+ + ++ E+M+N L ++ TP G++L + K Q+ +G+A Sbjct: 81 VRLYAVV-TQEPIYIITEYMENGSLVDFL------KTPSGIKLTINKLLDMAAQIAEGMA 133 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE---VVTLWYRAPDV 179 F E +HRDL+ N+L++ K+ DFGLAR I N +++ + + AP+ Sbjct: 134 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARL--IEDNEYTAREGAKFPIKWTAPEA 191 Query: 180 LMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLK 219 + T++ D+WS G +L E++T G+ +PG + E ++ Sbjct: 192 I-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQ 231 >4B6L-A nrPDB Length = 281 Score = 97.8 bits (242), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 70/248 (28%), Positives = 112/248 (45%), Gaps = 20/248 (8%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP---STAIREISLMKELKHENIVRLY 69 LG G +A Y+ + TG A+K + S P + EI L ++L+H +IVR Sbjct: 17 LGKGGFARCYEATDTETGSAYAVKVIP-QSRVAKPHQREKILNEIELHRDLQHRHIVRFS 75 Query: 70 DVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 + + + E L +R P V+Y+ Q+L GL + H+ Sbjct: 76 HHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPE------VRYYLRQILSGLKYLHQRG 129 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYST 188 ILHRDLK N I + +LK+GDFGLA P + T Y AP+VL+ + + Sbjct: 130 ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGP 188 Query: 189 SIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDI-------MGTPNESLWPSVTKL-P 240 D+WS GC++ ++ G P F + +E + I + + P L ++ + P Sbjct: 189 EADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASP 248 Query: 241 KYNPNIQQ 248 + P+I Q Sbjct: 249 RDRPSIDQ 256 >3Q5I-A nrPDB Length = 504 Score = 97.4 bits (241), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 71/229 (31%), Positives = 118/229 (51%), Gaps = 25/229 (10%) Query: 9 QLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIR-----------EISL 56 ++ KLG+G Y V K A+K +K ++G S + EISL Sbjct: 40 KVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISL 99 Query: 57 MKELKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQW 115 +K L H NI++L+DV + LV EF + +L + + +R + N++K Sbjct: 100 LKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAA--NIMK---- 153 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQL---KLGDFGLARAFGIPVNTFSSEVVTL 172 Q+L G+ + H++ I+HRD+KP+N+L+ + L K+ DFGL+ F + T Sbjct: 154 QILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDY-KLRDRLGTA 212 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLI 221 +Y AP+VL + Y+ D+WSCG I+ ++ G P F G ND++ +K + Sbjct: 213 YYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKV 259 >4RED-A nrPDB Length = 351 Score = 97.4 bits (241), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 79/295 (26%), Positives = 135/295 (45%), Gaps = 50/295 (16%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-----REISLMKELKHENI 65 + LG GT+ V G ++ TG VA VK+ + + S + REI +K +H +I Sbjct: 20 DTLGVGTFGKVKVGKHELTGHAVA---VKILNRQKIRSLDVVGKIRREIQNLKLFRHPHI 76 Query: 66 VRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 ++LY VI T + + +V E++ +L Y + R E + FQ Q+L G+ +C Sbjct: 77 IKLYQVISTPSDIFMVMEYVSGGELFDY-----ICKNGRLDEKESRRLFQ-QILSGVDYC 130 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 H + ++HRDLKP+N+L++ K+ DFGL+ + + Y AP+V+ G Sbjct: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRL 189 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 +DIWS G IL ++ G F D++ + +F + + + P+Y Sbjct: 190 YAGPEVDIWSSGVILYALLCGTLPF----DDDHVPTLF-------KKICDGIFYTPQY-- 236 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 L+ +++ L +LQ++P R S K H WF + Sbjct: 237 ---------------------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ 270 >2F57-A nrPDB Length = 317 Score = 97.4 bits (241), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 78/290 (26%), Positives = 131/290 (45%), Gaps = 47/290 (16%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 K+G G+ V K TG VA+K++ L ++ E+ +M++ H+N+V +Y Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRR-ELLFNEVVIMRDYHHDNVVDMYSS 110 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 ++L +V EF++ + + T N + + L +L+ L++ H ++H Sbjct: 111 YLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCL------SVLRALSYLHNQGVIH 164 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT-YSTSI 190 RD+K ++L+ G++KL DFG V S V T ++ AP+V+ SR Y T + Sbjct: 165 RDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVI--SRLPYGTEV 222 Query: 191 DIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN-PNIQQR 249 DIWS G ++ EMI G+P P +N P +Q Sbjct: 223 DIWSLGIMVIEMIDGEP--------------------------------PYFNEPPLQAM 250 Query: 250 PPRDLRQVLQPHTKE--PLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 R +R L P K+ + L FL +L P R +A++ L HP+ Sbjct: 251 --RRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFL 298 >5J5T-A nrPDB Length = 370 Score = 97.1 bits (240), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 100/207 (48%), Gaps = 8/207 (3%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 S F+ ++++G+GTY VYK N TG A+K +KL+ E + +EI +MK+ KH Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDF-AVVQQEIIMMKDCKH 60 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 NIV + +KL + EF D V L+ + Y + LQGL Sbjct: 61 PNIVAYFGSYLRRDKLWICMEFCGGG--SLQDIYHVTGPLSELQ---IAYVSRETLQGLY 115 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 + H +HRD+K N+L+ G +KL DFG++ + + + T ++ AP+V Sbjct: 116 YLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAV 175 Query: 183 SRT--YSTSIDIWSCGCILAEMITGKP 207 R Y+ D+W+ G E+ +P Sbjct: 176 ERKGGYNQLCDLWAVGITAIELAELQP 202 >4KS7-A nrPDB Length = 292 Score = 97.1 bits (240), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 74/288 (25%), Positives = 130/288 (45%), Gaps = 39/288 (13%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 K+G G+ V K +G VA+K + L ++ E+ +M++ +H N+V +Y Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRR-ELLFNEVVIMRDYQHFNVVEMYKS 88 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 +L ++ EF+ + S+ N + + +LQ LA+ H ++H Sbjct: 89 YLVGEELWVLMEFLQGGALTDIVSQVRLNEEQ------IATVCEAVLQALAYLHAQGVIH 142 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSID 191 RD+K ++L+ G++KL DFG V S V T ++ AP+V+ S Y+T +D Sbjct: 143 RDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRS-LYATEVD 201 Query: 192 IWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPP 251 IWS G ++ EM+ G+P + + + +K + D PP Sbjct: 202 IWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRD-------------------------SPP 236 Query: 252 RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 L+ H P+ L DFL +L +P R +A++ L HP+ + Sbjct: 237 PKLK---NSHKVSPV---LRDFLERMLVRDPQERATAQELLDHPFLLQ 278 >2XIK-A nrPDB Length = 294 Score = 97.1 bits (240), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 82/308 (26%), Positives = 135/308 (43%), Gaps = 58/308 (18%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F +L+++G G++ VYKG++ T VA+K + L+ E +EI+++ + I Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 80 Query: 67 RLYDVIHTENKLTLVFEFMDN----DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 R + KL ++ E++ DL K P LE + ++L+GL Sbjct: 81 RYFGSYLKSTKLWIIMEYLGGGSALDLLK----------PGPLEETYIATILREILKGLD 130 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFG---IPVNTFSSEVVTLWYRAPDV 179 + H + +HRD+K N+L++++G +KL DFG+A I NTF V T ++ AP+V Sbjct: 131 YLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTF---VGTPFWMAPEV 187 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP--SVT 237 + S Y DIWS G E+ G+P PN L P + Sbjct: 188 IKQS-AYDFKADIWSLGITAIELAKGEP--------------------PNSDLHPMRVLF 226 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 +PK +P L+ +P +F+ L +P R +AK+ L H + Sbjct: 227 LIPKNSP-----------PTLEGQHSKPFK----EFVEACLNKDPRFRPTAKELLKHKFI 271 Query: 298 AEYYHHAS 305 Y S Sbjct: 272 TRYTKKTS 279 >4CFH-A nrPDB Length = 493 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 78/295 (26%), Positives = 135/295 (45%), Gaps = 50/295 (16%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-----REISLMKELKHENI 65 + LG GT+ V G ++ TG VA VK+ + + S + REI +K +H +I Sbjct: 39 DTLGVGTFGKVKVGKHELTGHKVA---VKILNRQKIRSLDVVGKIRREIQNLKLFRHPHI 95 Query: 66 VRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 ++LY VI T + + +V E++ +L Y + R E + FQ Q+L G+ +C Sbjct: 96 IKLYQVISTPSDIFMVMEYVSGGELFDY-----ICKNGRLDEKESRRLFQ-QILSGVDYC 149 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 H + ++HRDLKP+N+L++ K+ DFGL+ + + Y AP+V+ G Sbjct: 150 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRL 208 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 +DIWS G IL ++ G F D++ + +F + + + P+Y Sbjct: 209 YAGPEVDIWSSGVILYALLCGTLPF----DDDHVPTLF-------KKICDGIFYTPQY-- 255 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 L+ +++ L +LQ++P R + K H WF + Sbjct: 256 ---------------------LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQ 289 >4QMW-A nrPDB Length = 310 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 79/291 (27%), Positives = 135/291 (46%), Gaps = 46/291 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F +LEK+G G++ V+KG++ T VA+K + L+ E +EI+++ + + Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 90 Query: 67 RLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 + Y + KL ++ E++ S P L+ + ++L+GL + H Sbjct: 91 KYYGSYLKDTKLWIIMEYLGGG------SALDLLEPGPLDETQIATILREILKGLDYLHS 144 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFG---IPVNTFSSEVVTLWYRAPDVLMGS 183 K +HRD+K N+L+++ G++KL DFG+A I NTF V T ++ AP+V+ S Sbjct: 145 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTF---VGTPFWMAPEVIKQS 201 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 Y + DIWS G E+ G+P ++ +K++F I PK N Sbjct: 202 -AYDSKADIWSLGITAIELARGEPPH---SELHPMKVLFLI---------------PKNN 242 Query: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 P L+ + +PL +F+ L P R +AK+ L H Sbjct: 243 P-----------PTLEGNYSKPLK----EFVEACLNKEPSFRPTAKELLKH 278 >2W4O-A nrPDB Length = 349 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 84/304 (27%), Positives = 132/304 (43%), Gaps = 59/304 (19%) Query: 5 SQFKQLE-KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 S F ++E +LG G + VY+ K T ALK +K ++ T EI ++ L H Sbjct: 52 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRT---EIGVLLRLSHP 108 Query: 64 NIVRLYDVIHTENKLTLVFEFM------DNDLKK-YMDSRTVGNTPRGLELNLVKYFQWQ 116 NI++L ++ T +++LV E + D ++K Y R + + Q Sbjct: 109 NIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVK------------Q 156 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINK---RGQLKLGDFGLARAFGIPVNTFSSEVVTLW 173 +L+ +A+ HEN I+HRDLKP+NLL LK+ DFGL++ V + T Sbjct: 157 ILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQV-LMKTVCGTPG 215 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITG-KPLFPGTNDEEQLKLIFDIMGTPNESL 232 Y AP++L G Y +D+WS G I ++ G +P + D+ + I + Sbjct: 216 YCAPEILRGC-AYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPW 274 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 W V+ N D + L+ L+P RL+ QAL Sbjct: 275 WDEVSL------------------------------NAKDLVRKLIVLDPKKRLTTFQAL 304 Query: 293 HHPW 296 HPW Sbjct: 305 QHPW 308 >1KOB-A nrPDB Length = 387 Score = 95.1 bits (235), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 76/295 (25%), Positives = 125/295 (42%), Gaps = 49/295 (16%) Query: 10 LEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPS-----TAIREISLMKELKHEN 64 LE+LG+G + V++ + K TG K + TP T EIS+M +L H Sbjct: 56 LEELGSGAFGVVHRCVEKATGRVFVAKFI------NTPYPLDKYTVKNEISIMNQLHHPK 109 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 ++ L+D + ++ L+ EF+ + R + E ++ Y + Q +GL Sbjct: 110 LINLHDAFEDKYEMVLILEFLSGG---ELFDRIAAEDYKMSEAEVINYMR-QACEGLKHM 165 Query: 125 HENKILHRDLKPQNLLI--NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 HE+ I+H D+KP+N++ K +K+ DFGLA P T + AP+++ Sbjct: 166 HEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLN-PDEIVKVTTATAEFAAPEIV-D 223 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 D+W+ G + +++G F G +D E L+ + +E + SV+ Sbjct: 224 REPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVS----- 278 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 P K DF+ LLQ P RL+ AL HPW Sbjct: 279 -----------------PEAK--------DFIKNLLQKEPRKRLTVHDALEHPWL 308 >1ZXE-A nrPDB Length = 303 Score = 95.1 bits (235), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 67/229 (29%), Positives = 111/229 (48%), Gaps = 37/229 (16%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 +S F+++ LG G + V K N Y A+K+++ E+ ST + E+ L+ L H+ Sbjct: 5 ASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEK--LSTILSEVMLLASLNHQ 62 Query: 64 NIVRLYD-----------VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKY 112 +VR Y + + K TL + +Y ++RT+ + LN + Sbjct: 63 YVVRYYAAWLERRNFVKPMTAVKKKSTLFIQM------EYCENRTLYDLIHSENLNQQRD 116 Query: 113 FQW----QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLA----RAFGI---- 160 W Q+L+ L++ H I+HR+LKP N+ I++ +K+GDFGLA R+ I Sbjct: 117 EYWRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLD 176 Query: 161 ------PVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMI 203 + +S + T Y A +VL G+ Y+ ID++S G I EMI Sbjct: 177 SQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI 225 >6CMJ-A nrPDB Length = 321 Score = 95.1 bits (235), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 79/310 (25%), Positives = 141/310 (45%), Gaps = 52/310 (16%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV---KLDSEEG---TPSTAI----REI 54 Q+ +++G G+Y V N+ Y A+K + KL + G P I +EI Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEI 93 Query: 55 SLMKELKHENIVRLYDVIH--TENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKY 112 +++K+L H N+V+L +V+ E+ L +VFE ++ M+ T+ + L + ++ Sbjct: 94 AILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQ--GPVMEVPTL----KPLSEDQARF 147 Query: 113 FQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTL 172 + L++G+ + H KI+HRD+KP NLL+ + G +K+ DFG++ F S+ V T Sbjct: 148 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 207 Query: 173 WYRAPDVLMGSRTY--STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNE 230 + AP+ L +R ++D+W+ G L + G+ F DE + L + Sbjct: 208 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF---MDERIMCL--------HS 256 Query: 231 SLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 + + P QP E +L D + +L NP+ R+ + Sbjct: 257 KIKSQALEFPD-----------------QPDIAE----DLKDLITRMLDKNPESRIVVPE 295 Query: 291 ALHHPWFAEY 300 HPW + Sbjct: 296 IKLHPWVTRH 305 >2YCR-A nrPDB Length = 323 Score = 94.7 bits (234), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 78/297 (26%), Positives = 135/297 (45%), Gaps = 48/297 (16%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKL------DSEEGTPSTAIR-EISLMKELKHENI 65 LG+G V + T VA+K + + E P+ + EI ++K+L H I Sbjct: 18 LGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 77 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 +++ + E+ +V E M+ + + VGN + L+ K + +Q+L + + H Sbjct: 78 IKIKNFFDAED-YYIVLELMEGG---ELFDKVVGN--KRLKEATCKLYFYQMLLAVQYLH 131 Query: 126 ENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL-- 180 EN I+HRDLKP+N+L++ + + +K+ DFG ++ G + + T Y AP+VL Sbjct: 132 ENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILG-ETSLMRTLCGTPTYLAPEVLVS 190 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 +G+ Y+ ++D WS G IL ++G P P + Q+ L I Sbjct: 191 VGTAGYNRAVDCWSLGVILFICLSGYP--PFSEHRTQVSLKDQITSG------------- 235 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 KYN P + +D + LL ++P R + ++AL HPW Sbjct: 236 KYN--------------FIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 278 >4PWN-A nrPDB Length = 274 Score = 94.4 bits (233), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 91/316 (28%), Positives = 141/316 (44%), Gaps = 64/316 (20%) Query: 1 MSSSSQFKQLE-KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR---EISL 56 MS+ +F + + ++G G++ TVYKGL+ T V VA E L + T S R E + Sbjct: 5 MSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCE--LQDRKLTKSERQRFKEEAEM 62 Query: 57 MKELKHENIVRLYD----VIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVK 111 +K L+H NIVR YD + + + LV E M LK Y+ V +++ +++ Sbjct: 63 LKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKV------MKIKVLR 116 Query: 112 YFQWQLLQGLAFCHENK--ILHRDLKPQNLLINK-RGQLKLGDFGLA----RAFGIPVNT 164 + Q+L+GL F H I+HRDLK N+ I G +K+GD GLA RA + Sbjct: 117 SWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRA------S 170 Query: 165 FSSEVV-TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFD 223 F+ V+ T + AP+ M Y S+D+++ G + EM T + + + Q+ Sbjct: 171 FAKSVIGTPEFMAPE--MYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQI----- 223 Query: 224 IMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPD 283 Y P +V P KE + G ++ N D Sbjct: 224 ------------------YRRVTSGVKPASFDKVAIPEVKE--------IIEGCIRQNKD 257 Query: 284 MRLSAKQALHHPWFAE 299 R S K L+H +F E Sbjct: 258 ERYSIKDLLNHAFFQE 273 >5WAX-A nrPDB Length = 310 Score = 94.4 bits (233), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 76/300 (25%), Positives = 130/300 (43%), Gaps = 40/300 (13%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 M +++ + +G+G + N+ G VA+K + + E REI + L Sbjct: 7 MHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYI--ERGEKIDENVQREIINHRSL 64 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +H NI+R +VI T L +V E+ + N R E + ++F QL+ G Sbjct: 65 RHPNIIRFKEVILTPTHLAIVMEYASGGEL----FERICNAGRFSE-DEARFFFQQLISG 119 Query: 121 LAFCHENKILHRDLKPQNLLINKRG--QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 +++CH ++ HRDLK +N L++ +LK+ DFG +++ + + S V T Y AP+ Sbjct: 120 VSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPE 178 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQL-KLIFDIMGTPNESLWPSVT 237 VL+ D+WSCG L M+ G F ++ + K I I+G + S+ Sbjct: 179 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILG-----VQYSIP 233 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 +P Q D + + NP R++ + +HPWF Sbjct: 234 DYVHISPECQ------------------------DLISRIFVANPATRITIPEIRNHPWF 269 >5UNP-A nrPDB Length = 369 Score = 94.4 bits (233), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 88/337 (26%), Positives = 152/337 (45%), Gaps = 62/337 (18%) Query: 6 QFKQLEKLGNGTYATVYKGLN-KTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 +++ + LG GT+ V + ++ + G VALK +K + E A EI++++++ ++ Sbjct: 35 RYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK--NVEKYKEAARLEINVLEKINEKD 92 Query: 65 ------IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 V+++D + + FE + ++ P ++ V++ +QL Sbjct: 93 PDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYP----IHQVRHMAFQLC 148 Query: 119 QGLAFCHENKILHRDLKPQNLLI------------NKRGQ-------LKLGDFGLARAFG 159 Q + F H+NK+ H DLKP+N+L KR + +++ DFG A Sbjct: 149 QAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA---- 204 Query: 160 IPVNTFSSE-----VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTND 214 TF E V T YRAP+V++ +S D+WS GCI+ E G LF ++ Sbjct: 205 ----TFDHEHHSTIVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDN 259 Query: 215 EEQLKLIFDIMGTPNESLWPSVTKLPKY--------NPNIQ-----QRPPRDLRQVLQPH 261 E L ++ I+G P S T+ KY + N + + LR+ L Sbjct: 260 REHLAMMERILG-PIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSE 318 Query: 262 TKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 +E L D + +L+ P RL+ +AL HP+FA Sbjct: 319 AEE--HHQLFDLIESMLEYEPAKRLTLGEALQHPFFA 353 >2WTK-C nrPDB Length = 305 Score = 94.0 bits (232), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 80/293 (27%), Positives = 131/293 (44%), Gaps = 46/293 (15%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP---STAIREISLMKELKHENIVRLY 69 LG G+Y V + L+ T A+K +K P + +EI L++ L+H+N+++L Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLV 72 Query: 70 DVIHTE--NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 DV++ E K+ +V E+ +++ +DS P YF QL+ GL + H Sbjct: 73 DVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPV---CQAHGYF-CQLIDGLEYLHSQ 128 Query: 128 KILHRDLKPQNLLINKRGQLKLGDFGLARAFG--IPVNTFSSEVVTLWYRAPDVLMGSRT 185 I+H+D+KP NLL+ G LK+ G+A A +T + + ++ P++ G T Sbjct: 129 GIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDT 188 Query: 186 YST-SIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 +S +DIWS G L + TG F G N + +F+ +G + ++ P P Sbjct: 189 FSGFKVDIWSAGVTLYNITTGLYPFEGDN----IYKLFENIGKGSYAI-PGDCGPP---- 239 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 L D L G+L+ P R S +Q H WF Sbjct: 240 -------------------------LSDLLKGMLEYEPAKRFSIRQIRQHSWF 267 >3F3Z-A nrPDB Length = 277 Score = 93.6 bits (231), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 81/299 (27%), Positives = 125/299 (41%), Gaps = 47/299 (15%) Query: 5 SQFKQLEK-LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 +Q+ LE +G G++ V + K T + A K++ E +EI +MK L H Sbjct: 8 NQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFK-QEIEIMKSLDHP 66 Query: 64 NIVRLYDVIHTENKLTLVFEFMDND--LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NI+RLY+ + LV E ++ + R + + +L + Sbjct: 67 NIIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMK-------DVLSAV 119 Query: 122 AFCHENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 A+CH+ + HRDLKP+N L + LKL DFGLA F P ++V T +Y +P Sbjct: 120 AYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFK-PGKMMRTKVGTPYYVSPQ 178 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL G Y D WS G ++ ++ G P F D E + I + T E W +V+ Sbjct: 179 VLEG--LYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVS- 235 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 P + + LL +P R+++ QAL H WF Sbjct: 236 ---------------------PQAE--------SLIRRLLTKSPKQRITSLQALEHEWF 265 >5O2B-A nrPDB Length = 285 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 89/311 (28%), Positives = 140/311 (45%), Gaps = 57/311 (18%) Query: 2 SSSSQFKQLE-KLGNGTYATVYKGLNKTTGVYVA---LKEVKLDSEEGTPSTAIREISLM 57 S S +F + + +LG G + TVYKGL+ T V VA L++ KL E E ++ Sbjct: 12 SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAE--QQRFKEEAEML 69 Query: 58 KELKHENIVRLYD----VIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKY 112 K L+H NIVR YD ++ + + LV E M + LK Y+ V ++ +++ Sbjct: 70 KGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKV------MKPKVLRS 123 Query: 113 FQWQLLQGLAFCHENK--ILHRDLKPQNLLINK-RGQLKLGDFGLARAFGIPVNTFSSEV 169 + Q+L+GL F H I+HRDLK N+ I G +K+GD GLA + +F+ V Sbjct: 124 WCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA---TLMRTSFAKSV 180 Query: 170 V-TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTP 228 + T + AP+ M Y S+D+++ G + EM T + + + Q+ Sbjct: 181 IGTPEFMAPE--MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQI---------- 228 Query: 229 NESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA 288 Y P +V P KE + G ++ N RLS Sbjct: 229 -------------YRKVTSGIKPASFNKVTDPEVKE--------IIEGCIRQNKSERLSI 267 Query: 289 KQALHHPWFAE 299 + L+H +FAE Sbjct: 268 RDLLNHAFFAE 278 >5TUR-A nrPDB Length = 404 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 69/226 (30%), Positives = 112/226 (49%), Gaps = 22/226 (9%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIR---EISLMKE 59 SQ++ LG+G + +VY G+ + + VA+K V+ D S+ G R E+ L+K+ Sbjct: 127 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 186 Query: 60 LKH--ENIVRLYDVIHTENKLTLVFEFMD--NDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 + ++RL D + L+ E + DL ++ R L+ L + F W Sbjct: 187 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG------ALQEELARSFFW 240 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNT-FSSEVVTLW 173 Q+L+ + CH +LHRD+K +N+LI+ RG+LKL DFG V T F V Sbjct: 241 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV--- 297 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLK 219 Y P+ + R + S +WS G +L +M+ G P +DEE ++ Sbjct: 298 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGD--IPFEHDEEIIR 341 >4C0T-A nrPDB Length = 974 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 64/227 (28%), Positives = 115/227 (50%), Gaps = 28/227 (12%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALK---EVKLDSEEGTPSTAIREISLMKELK 61 + FK ++LG G+Y+TV +K TG A+K + + E+ I + +L + Sbjct: 266 TDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSN 325 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDND-----LKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 ++ LY ++ L V ++ N +K+Y NT L ++F Q Sbjct: 326 RLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRY-------NT---LNEECTRHFGAQ 375 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLAR--------AFGIPVNTFSSE 168 +L + + H+N ++HRDLKP+N+L++ + ++++ DFG AR + PV+ + Sbjct: 376 ILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKS 435 Query: 169 VV-TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTND 214 V T Y +P+ L+ ++ D+W+ GCI+ +MI GKP F TN+ Sbjct: 436 FVGTAEYVSPE-LLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNE 481 >5O2C-A nrPDB Length = 380 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 89/311 (28%), Positives = 140/311 (45%), Gaps = 57/311 (18%) Query: 2 SSSSQFKQLE-KLGNGTYATVYKGLNKTTGVYVA---LKEVKLDSEEGTPSTAIREISLM 57 S S +F + + +LG G + TVYKGL+ T V VA L++ KL E E ++ Sbjct: 21 SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAE--QQRFKEEAEML 78 Query: 58 KELKHENIVRLYD----VIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKY 112 K L+H NIVR YD ++ + + LV E M + LK Y+ V ++ +++ Sbjct: 79 KGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKV------MKPKVLRS 132 Query: 113 FQWQLLQGLAFCHENK--ILHRDLKPQNLLINK-RGQLKLGDFGLARAFGIPVNTFSSEV 169 + Q+L+GL F H I+HRDLK N+ I G +K+GD GLA + +F+ V Sbjct: 133 WCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA---TLMRTSFAKSV 189 Query: 170 V-TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTP 228 + T + AP+ M Y S+D+++ G + EM T + + + Q+ Sbjct: 190 IGTPEFMAPE--MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQI---------- 237 Query: 229 NESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA 288 Y P +V P KE + G ++ N RLS Sbjct: 238 -------------YRKVTSGIKPASFNKVTDPEVKE--------IIEGCIRQNKSERLSI 276 Query: 289 KQALHHPWFAE 299 + L+H +FAE Sbjct: 277 RDLLNHAFFAE 287 >3I6U-A nrPDB Length = 419 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 77/299 (25%), Positives = 136/299 (45%), Gaps = 48/299 (16%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKL------DSEEGTPSTAIR-EISLMKELKHENI 65 LG+G V + T VA++ + + E P+ + EI ++K+L H I Sbjct: 143 LGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 202 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 +++ + E+ +V E M+ + + VGN + L+ K + +Q+L + + H Sbjct: 203 IKIKNFFDAED-YYIVLELMEGG---ELFDKVVGN--KRLKEATCKLYFYQMLLAVQYLH 256 Query: 126 ENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL-- 180 EN I+HRDLKP+N+L++ + + +K+ DFG ++ G + + T Y AP+VL Sbjct: 257 ENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILG-ETSLMRTLCGTPTYLAPEVLVS 315 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 +G+ Y+ ++D WS G IL ++G P P + Q+ L I Sbjct: 316 VGTAGYNRAVDCWSLGVILFICLSGYP--PFSEHRTQVSLKDQITSG------------- 360 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 KYN P + +D + LL ++P R + ++AL HPW + Sbjct: 361 KYN--------------FIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 >5F9E-A nrPDB Length = 353 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 107/208 (51%), Gaps = 11/208 (5%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDS---EEGTPSTAIREISLMKELKHENIVRLY 69 LG G++ V+ K T + A+K +K D ++ T + + L +H + ++ Sbjct: 27 LGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMF 86 Query: 70 DVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 T+ L V E+++ DL ++ S +L+ ++ +++ GL F H Sbjct: 87 CTFQTKENLFFVMEYLNGGDLMYHIQS------CHKFDLSRATFYAAEIILGLQFLHSKG 140 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYST 188 I++RDLK N+L++K G +K+ DFG+ + + + T Y AP++L+G + Y+ Sbjct: 141 IVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQK-YNH 199 Query: 189 SIDIWSCGCILAEMITGKPLFPGTNDEE 216 S+D WS G +L EM+ G+ F G ++EE Sbjct: 200 SVDWWSFGVLLYEMLIGQSPFHGQDEEE 227 >4TNB-A nrPDB Length = 590 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 67/217 (30%), Positives = 108/217 (49%), Gaps = 11/217 (5%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALK--EVKLDSEEGTPSTAIREISLMKEL 60 + + F+Q LG G + V + TG A K E K + S A+ E +++++ Sbjct: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 + +V L T++ L LV M+ DLK ++ +GN G E ++ ++L Sbjct: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI--YNMGNP--GFEEERALFYAAEILC 297 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPV-NTFSSEVVTLWYRAPD 178 GL H ++RDLKP+N+L++ G +++ D GL A IP + V T+ Y AP+ Sbjct: 298 GLEDLHHENTVYRDLKPENILLDDYGHIRISDLGL--AVKIPEGDLIRGRVGTVGYMAPE 355 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDE 215 VL R Y S D W GC++ EMI G+ F G ++ Sbjct: 356 VLNNQR-YGLSPDYWGLGCLIYEMIEGQSPFRGRKEK 391 >4RC3-A nrPDB Length = 289 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 69/226 (30%), Positives = 112/226 (49%), Gaps = 22/226 (9%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIR---EISLMKE 59 SQ++ LG+G + +VY G+ + + VA+K V+ D S+ G R E+ L+K+ Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 71 Query: 60 LKH--ENIVRLYDVIHTENKLTLVFEFMD--NDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 + ++RL D + L+ E + DL ++ R L+ L + F W Sbjct: 72 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG------ALQEELARSFFW 125 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNT-FSSEVVTLW 173 Q+L+ + CH +LHRD+K +N+LI+ RG+LKL DFG V T F V Sbjct: 126 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV--- 182 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLK 219 Y P+ + R + S +WS G +L +M+ G P +DEE ++ Sbjct: 183 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGD--IPFEHDEEIIR 226 >3BGP-A nrPDB Length = 333 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 69/226 (30%), Positives = 112/226 (49%), Gaps = 22/226 (9%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIR---EISLMKE 59 SQ++ LG+G + +VY G+ + + VA+K V+ D S+ G R E+ L+K+ Sbjct: 56 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 115 Query: 60 LKH--ENIVRLYDVIHTENKLTLVFEFMD--NDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 + ++RL D + L+ E + DL ++ R L+ L + F W Sbjct: 116 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG------ALQEELARSFFW 169 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNT-FSSEVVTLW 173 Q+L+ + CH +LHRD+K +N+LI+ RG+LKL DFG V T F V Sbjct: 170 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV--- 226 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLK 219 Y P+ + R + S +WS G +L +M+ G P +DEE ++ Sbjct: 227 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGD--IPFEHDEEIIR 270 >1ZWS-A nrPDB Length = 288 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 78/296 (26%), Positives = 128/296 (43%), Gaps = 48/296 (16%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVK----LDSEEGTPSTAI-REISLMKELKHENI 65 E+LG+G +A V K K+TG+ A K +K S G I RE+S+++++ H N+ Sbjct: 18 EELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNV 77 Query: 66 VRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 + L+DV + L+ E + +L ++ + L F Q+L G+ + Sbjct: 78 ITLHDVYENRTDVVLILELVSGGELFDFLAQK------ESLSEEEATSFIKQILDGVNYL 131 Query: 125 HENKILHRDLKPQNLLINKRG----QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 H KI H DLKP+N+++ + +KL DFGLA V F + T + AP++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVAPEI- 189 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 + D+WS G I +++G F G +E L I + +E + ++L Sbjct: 190 VNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFSHTSELA 249 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 K DF+ LL RL+ ++AL HPW Sbjct: 250 K------------------------------DFIRKLLVKETRKRLTIQEALRHPW 275 >4FZF-B nrPDB Length = 283 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 75/296 (25%), Positives = 134/296 (45%), Gaps = 46/296 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F +LE++G G++ V+KG++ T VA+K + L+ E +EI+++ + + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 69 Query: 67 RLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 + Y +KL ++ E++ +D G ++K ++L+GL + H Sbjct: 70 KYYGSYLKGSKLWIIMEYLGGG--SALDLLRAGPFDEFQIATMLK----EILKGLDYLHS 123 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFG---IPVNTFSSEVVTLWYRAPDVLMGS 183 K +HRD+K N+L++++G +KL FG+A I NTF V T ++ AP+V+ S Sbjct: 124 EKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTF---VGTPFWMAPEVIQQS 180 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 Y + DIWS G E+ G+ P +D ++++F I PK N Sbjct: 181 -AYDSKADIWSLGITAIELAKGE---PPNSDMHPMRVLFLI---------------PKNN 221 Query: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 P P + +F+ L +P R +AK+ L H + + Sbjct: 222 P---------------PTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVK 262 >2A27-A nrPDB Length = 321 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 78/296 (26%), Positives = 128/296 (43%), Gaps = 48/296 (16%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVK----LDSEEGTPSTAI-REISLMKELKHENI 65 E+LG+G +A V K K+TG+ A K +K S G I RE+S+++++ H N+ Sbjct: 18 EELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNV 77 Query: 66 VRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 + L+DV + L+ E + +L ++ + L F Q+L G+ + Sbjct: 78 ITLHDVYENRTDVVLILELVSGGELFDFLAQK------ESLSEEEATSFIKQILDGVNYL 131 Query: 125 HENKILHRDLKPQNLLINKRG----QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 H KI H DLKP+N+++ + +KL DFGLA V F + T + AP++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVAPEI- 189 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 + D+WS G I +++G F G +E L I + +E + ++L Sbjct: 190 VNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELA 249 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 K DF+ LL RL+ ++AL HPW Sbjct: 250 K------------------------------DFIRKLLVKETRKRLTIQEALRHPW 275 >4WUA-A nrPDB Length = 401 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 97/371 (26%), Positives = 162/371 (43%), Gaps = 88/371 (23%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH- 62 + ++ + KLG G ++TV+ + +VA+K VK S E TA+ EI L+K +++ Sbjct: 40 NGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK--SAEHYTETALDEIRLLKSVRNS 97 Query: 63 -------ENIVRLYDVIHTEN----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVK 111 E +V+L D + +VFE + + L K++ + + +GL L VK Sbjct: 98 DPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWI----IKSNYQGLPLPCVK 153 Query: 112 YFQWQLLQGLAFCH-ENKILHRDLKPQNLLINKRGQ------------------------ 146 Q+LQGL + H + +I+H D+KP+N+L++ Q Sbjct: 154 KIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSA 213 Query: 147 -------------------------LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 +K+ D G A F+ ++ T YR+ +VL+ Sbjct: 214 VSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH---KHFTEDIQTRQYRSLEVLI 270 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPG------TNDEEQLKLIFDIMGTPNESLWPS 235 GS Y+T DIWS C+ E+ TG LF T DE+ + LI +++G L + Sbjct: 271 GS-GYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVA 329 Query: 236 VTKLPKYN------PNIQQRPPRDLRQVLQPH---TKEPLDGNLMDFLHGLLQLNPDMRL 286 ++ +I + P L +VL ++E G DFL +L+L P+ R Sbjct: 330 GKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAG-FTDFLLPMLELIPEKRA 388 Query: 287 SAKQALHHPWF 297 +A + L HPW Sbjct: 389 TAAECLRHPWL 399 >5H2U-A nrPDB Length = 267 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 83/269 (30%), Positives = 133/269 (49%), Gaps = 25/269 (9%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS---EEGTPSTAIREISLMKELKH 62 +F KLG+G + V++GL K V VA+K + D+ ++ S EI MK+L+H Sbjct: 7 EFTLCRKLGSGYFGEVFEGLWKDR-VQVAIKVISRDNLLHQQMLQS----EIQAMKKLRH 61 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND--LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 ++I+ LY V+ + + ++ E M L+ DS + L ++ + WQ+ +G Sbjct: 62 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDS-----DEKVLPVSELLDIAWQVAEG 116 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 + + +HRDL +N+L+ + K+GDFGLAR V + + AP+ L Sbjct: 117 MCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL 176 Query: 181 MGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDI---MGTPNESLWPSV 236 YST D+WS G +L EM + G+ +PG ++ E L D M P E PSV Sbjct: 177 SRGH-YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAF-LRVDAGYRMPCPLECP-PSV 233 Query: 237 TK--LPKYNPNIQQRPP-RDLRQVLQPHT 262 K L + + +QRP + LR+ L T Sbjct: 234 HKLMLTCWCRDPEQRPTFKALRERLSSFT 262 >4RLP-A nrPDB Length = 288 Score = 91.7 bits (226), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 68/226 (30%), Positives = 115/226 (50%), Gaps = 20/226 (8%) Query: 7 FKQLEKLGNGTYATVY---KGLNKTTGVYVALKEVK----LDSEEGTPSTAIREISLMKE 59 F+ L LG G Y V+ K TG A+K +K + + + T T E ++++E Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA-ERNILEE 65 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 +KH IV L T KL L+ E++ + +M G + ++ ++ Sbjct: 66 VKHPFIVDLIYAFQTGGKLYLILEYLSGG-ELFMQLEREGIFME----DTACFYLAEISM 120 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF---GIPVNTFSSEVVTLWYRA 176 L H+ I++RDLKP+N+++N +G +KL DFGL + G +TF T+ Y A Sbjct: 121 ALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCG---TIEYMA 177 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIF 222 P++LM S ++ ++D WS G ++ +M+TG P F G N ++ + I Sbjct: 178 PEILMRS-GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKIL 222 >4L42-A nrPDB Length = 346 Score = 91.7 bits (226), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 68/226 (30%), Positives = 115/226 (50%), Gaps = 20/226 (8%) Query: 7 FKQLEKLGNGTYATVY---KGLNKTTGVYVALKEVK----LDSEEGTPSTAIREISLMKE 59 F+ L LG G Y V+ K TG A+K +K + + + T T E ++++E Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA-ERNILEE 78 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 +KH IV L T KL L+ E++ + +M G + ++ ++ Sbjct: 79 VKHPFIVDLIYAFQTGGKLYLILEYLSGG-ELFMQLEREGI----FMEDTACFYLAEISM 133 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF---GIPVNTFSSEVVTLWYRA 176 L H+ I++RDLKP+N+++N +G +KL DFGL + G +TF T+ Y A Sbjct: 134 ALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCG---TIEYMA 190 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIF 222 P++LM S ++ ++D WS G ++ +M+TG P F G N ++ + I Sbjct: 191 PEILMRS-GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKIL 235 >2J90-A nrPDB Length = 304 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 75/296 (25%), Positives = 131/296 (44%), Gaps = 48/296 (16%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVK----LDSEEGTPSTAI-REISLMKELKHENI 65 E+LG+G +A V K K TG A K +K S G I RE+++++E++H NI Sbjct: 32 EELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNI 91 Query: 66 VRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 + L+D+ + + L+ E + +L ++ + L + F Q+L G+ + Sbjct: 92 ITLHDIFENKTDVVLILELVSGGELFDFLAEK------ESLTEDEATQFLKQILDGVHYL 145 Query: 125 HENKILHRDLKPQNLLINKRG----QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 H +I H DLKP+N+++ + ++KL DFG+A N F + T + AP+++ Sbjct: 146 HSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAG-NEFKNIFGTPEFVAPEIV 204 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 D+WS G I +++G F G +E L I + +E + + ++L Sbjct: 205 -NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELA 263 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 K DF+ LL +P R++ Q+L H W Sbjct: 264 K------------------------------DFIRRLLVKDPKRRMTIAQSLEHSW 289 >5D9K-A nrPDB Length = 330 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 74/237 (31%), Positives = 122/237 (51%), Gaps = 19/237 (8%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTG-----VYV--ALKEVKLDSEEGTPSTAIREI 54 + SQF+ L+ LG G++ V+ + K +G +Y LK+ L + + R+I Sbjct: 27 ADPSQFELLKVLGQGSFGKVFL-VKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDI 85 Query: 55 SLMKELKHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYF 113 + E+ H IV+L+ TE KL L+ +F+ DL + S+ V T VK++ Sbjct: 86 --LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRL-SKEVMFTEED-----VKFY 137 Query: 114 QWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW 173 +L L H I++RDLKP+N+L+++ G +KL DFGL++ S T+ Sbjct: 138 LAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVE 197 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDI-MGTPN 229 Y AP+V+ R ++ S D WS G ++ EM+TG F G + +E + +I +G P Sbjct: 198 YMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQ 253 >4AF3-A nrPDB Length = 292 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 79/288 (27%), Positives = 121/288 (42%), Gaps = 48/288 (16%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSE---EGTPSTAIREISLMKELKHENIVRLY 69 LG G + VY K + VALK V S+ EG REI + L H NI+RLY Sbjct: 31 LGKGKFGNVYLAREKKSHFIVALK-VLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLY 89 Query: 70 DVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 + + ++ L+ E+ +L K + + R + +L L +CH K Sbjct: 90 NYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI------MEELADALMYCHGKK 143 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYST 188 ++HRD+KP+NLL+ +G+LK+ DFG + P + TL Y P+++ G R ++ Sbjct: 144 VIHRDIKPENLLLGLKGELKIADFGW--SVHAPSLRRKTMCGTLDYLPPEMIEG-RMHNE 200 Query: 189 SIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQ 248 +D+W G + E++ G P F + E + I + K P P Q Sbjct: 201 KVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVD-----------LKFPASVPTGAQ 249 Query: 249 RPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 D + LL+ NP RL Q HPW Sbjct: 250 -----------------------DLISKLLRHNPSERLPLAQVSAHPW 274 >3GUB-A nrPDB Length = 295 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 77/298 (25%), Positives = 133/298 (44%), Gaps = 52/298 (17%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKL----DSEEGTPSTAI-REISLMKELKHENI 65 E+LG+G +A V K K+TG+ A K +K S G I RE+S++KE++H N+ Sbjct: 17 EELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNV 76 Query: 66 VRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 + L++V + + L+ E + +L ++ + E F Q+L G+ + Sbjct: 77 ITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATE------FLKQILNGVYYL 130 Query: 125 HENKILHRDLKPQNLLINKRG----QLKLGDFGLARA--FGIPVNTFSSEVVTLWYRAPD 178 H +I H DLKP+N+++ R ++K+ DFGLA FG N F + T + AP+ Sbjct: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFG---NEFKNIFGTPEFVAPE 187 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 ++ D+WS G I +++G F G +E L + + + + + + Sbjct: 188 IV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSA 246 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 L K DF+ LL +P R++ + +L HPW Sbjct: 247 LAK------------------------------DFIRRLLVKDPKKRMTIQDSLQHPW 274 >2YAB-A nrPDB Length = 361 Score = 91.3 bits (225), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 79/298 (26%), Positives = 128/298 (42%), Gaps = 48/298 (16%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVK----LDSEEGTPSTAI-REISLMKELKHENI 65 E+LG+G +A V K K+TG+ A K +K S G I RE+S+++++ H NI Sbjct: 18 EELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNI 77 Query: 66 VRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 + L+DV + L+ E + +L ++ + L F Q+L G+ + Sbjct: 78 ITLHDVYENRTDVVLILELVSGGELFDFLAQK------ESLSEEEATSFIKQILDGVNYL 131 Query: 125 HENKILHRDLKPQNLLINKRG----QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 H KI H DLKP+N+++ + +KL DFGLA V F + T + AP++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVAPEI- 189 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 + D+WS G I +++G F G +E L I + +E + ++L Sbjct: 190 VNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELA 249 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 K DF+ LL RL+ ++AL HPW Sbjct: 250 K------------------------------DFIRKLLVKETRKRLTIQEALRHPWIT 277 >2Z7Q-A nrPDB Length = 321 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 71/234 (30%), Positives = 120/234 (51%), Gaps = 13/234 (5%) Query: 2 SSSSQFKQLEKLGNGTYATVY---KGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLM 57 + S F+ L+ LG G++ V+ K +G A+K +K + + + E ++ Sbjct: 25 ADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDIL 84 Query: 58 KELKHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 ++ H +V+L+ TE KL L+ +F+ DL + S+ V T VK++ + Sbjct: 85 ADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRL-SKEVMFTEED-----VKFYLAE 138 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 L GL H I++RDLKP+N+L+++ G +KL DFGL++ S T+ Y A Sbjct: 139 LALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMA 198 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDI-MGTPN 229 P+V+ + +S S D WS G ++ EM+TG F G + +E + LI +G P Sbjct: 199 PEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQ 251 >2JD5-A nrPDB Length = 373 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 92/336 (27%), Positives = 153/336 (45%), Gaps = 54/336 (16%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 +++ + KLG G ++TV+ + +VA+K V+ D + A EI L++ + Sbjct: 18 DARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGD--KVYTEAAEDEIKLLQRVNDA 75 Query: 64 N-----------IVRLYDVIHTEN----KLTLVFEFMDNDL----KKYMDSRTVGNTPRG 104 + I++L D + + + +VFE + +L KKY RG Sbjct: 76 DNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKY--------EHRG 127 Query: 105 LELNLVKYFQWQLLQGLAFCHEN-KILHRDLKPQNLLINKRG------QLKLGDFGLARA 157 + L VK QLL GL + H I+H D+KP+N+L+ Q+K+ D G A Sbjct: 128 IPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACW 187 Query: 158 FGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG------ 211 + +++ + T YR+P+VL+G+ + DIWS C++ E+ITG LF Sbjct: 188 YD---EHYTNSIQTREYRSPEVLLGA-PWGCGADIWSTACLIFELITGDFLFEPDEGHSY 243 Query: 212 TNDEEQLKLIFDIMGT-PNESLWPSVTKLPKYNP-----NIQQRPPRDLRQVLQPHTKEP 265 T D++ + I +++G P+ L +N NI + L VL K Sbjct: 244 TKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFS 303 Query: 266 LD--GNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 D + DFL +LQL+P R A ++HPW + Sbjct: 304 KDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKD 339 >6FYV-A nrPDB Length = 337 Score = 90.5 bits (223), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 79/332 (23%), Positives = 149/332 (44%), Gaps = 52/332 (15%) Query: 5 SQFKQLEKLGNGTYATVYKGLNK-TTGVYVALKEVKLDSEEGTPSTAIR-EISLMKELKH 62 ++++ ++ LG G + V + ++ G++VA+K VK G A R EI +++ L Sbjct: 14 ARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVK---NVGRYREAARSEIQVLEHLNS 70 Query: 63 EN------IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 + V++ + + +VFE + ++ N+ +++ ++ +Q Sbjct: 71 TDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKE----NSFLPFQIDHIRQMAYQ 126 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRG-------------------QLKLGDFGLARA 157 + Q + F H NK+ H DLKP+N+L K +K+ DFG A Sbjct: 127 ICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA-- 184 Query: 158 FGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQ 217 S+ V T YRAP+V++ + +S D+WS GCIL E G +F + +E Sbjct: 185 -TYDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEH 242 Query: 218 LKLIFDIMGTPNESLWPSVTKLPKYNPN------------IQQRPPRDLRQVLQPHTKEP 265 L ++ I+G + + K ++ N +R + L++ + H +E Sbjct: 243 LAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEE- 301 Query: 266 LDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 L D + +L+ +P R++ +AL HP+F Sbjct: 302 -HEKLFDLVRRMLEYDPTQRITLDEALQHPFF 332 >2GCD-A nrPDB Length = 309 Score = 90.5 bits (223), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 61/206 (29%), Positives = 104/206 (50%), Gaps = 15/206 (7%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP--STAIREISLMKELKHEN 64 F L ++G+G++ VY + VA+K++ ++ I+E+ +++L+H N Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTP-RGLELNLVKYFQWQLLQGLAF 123 ++ E+ LV E+ L D V P + +E+ V + LQGLA+ Sbjct: 77 TIQYRGCYLREHTAWLVMEYC---LGSASDLLEVHKKPLQEVEIAAVTH---GALQGLAY 130 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL--M 181 H + ++HRD+K N+L+++ G +KLGDFG A P N+F V T ++ AP+V+ M Sbjct: 131 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMA-PANSF---VGTPYWMAPEVILAM 186 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKP 207 Y +D+WS G E+ KP Sbjct: 187 DEGQYDGKVDVWSLGITCIELAERKP 212 >5X8I-B nrPDB Length = 346 Score = 90.5 bits (223), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 82/332 (24%), Positives = 151/332 (45%), Gaps = 50/332 (15%) Query: 4 SSQFKQLEKLGNGTYATVYKGLN-KTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 S++++ ++ LG G + V + ++ K G +VA+K VK + + A EI +++ L Sbjct: 12 SARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK--NVDRYCEAARSEIQVLEHLNT 69 Query: 63 EN------IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 + V++ + + +VFE + L Y + G P L+ ++ +Q Sbjct: 70 TDPNSTFRCVQMLEWFEHHGHICIVFELLG--LSTYDFIKENGFLP--FRLDHIRKMAYQ 125 Query: 117 LLQGLAFCHENKILHRDLKPQNLLIN------------KRGQ-------LKLGDFGLARA 157 + + + F H NK+ H DLKP+N+L KR + +K+ DFG A Sbjct: 126 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA-- 183 Query: 158 FGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQ 217 S+ V T YRAP+V++ + +S D+WS GCIL E G +FP + +E Sbjct: 184 -TYDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEH 241 Query: 218 LKLIFDIMGTPNESLWPSVTKLPKYNPN------------IQQRPPRDLRQVLQPHTKEP 265 L ++ I+G + + K ++ + R + L++ + E Sbjct: 242 LAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVE- 300 Query: 266 LDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 L D + +L+ +P R++ ++AL HP+F Sbjct: 301 -HERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >1U5R-A nrPDB Length = 348 Score = 90.5 bits (223), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 61/206 (29%), Positives = 104/206 (50%), Gaps = 15/206 (7%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP--STAIREISLMKELKHEN 64 F L ++G+G++ VY + VA+K++ ++ I+E+ +++L+H N Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTP-RGLELNLVKYFQWQLLQGLAF 123 ++ E+ LV E+ L D V P + +E+ V + LQGLA+ Sbjct: 116 TIQYRGCYLREHTAWLVMEYC---LGSASDLLEVHKKPLQEVEIAAVTH---GALQGLAY 169 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL--M 181 H + ++HRD+K N+L+++ G +KLGDFG A P N+F V T ++ AP+V+ M Sbjct: 170 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMA-PANSF---VGTPYWMAPEVILAM 225 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKP 207 Y +D+WS G E+ KP Sbjct: 226 DEGQYDGKVDVWSLGITCIELAERKP 251 >5DBX-A nrPDB Length = 328 Score = 90.1 bits (222), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 62/205 (30%), Positives = 101/205 (49%), Gaps = 12/205 (5%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E +G+G A V L K VA+K + L+ + + ++EI M + H N+V Y Sbjct: 17 EVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYT 76 Query: 71 VIHTENKLTLVFEFMDN----DLKKYMDSRTVGNTPRG-LELNLVKYFQWQLLQGLAFCH 125 +++L LV + + D+ KY+ +R G G LE ++ ++L+GL + H Sbjct: 77 SFVVKDELWLVMKLLSGGSMLDIIKYIVNR--GEHKNGVLEEAIIATILKEVLEGLDYLH 134 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFG----LARAFGIPVNTFSSEVV-TLWYRAPDVL 180 N +HRDLK N+L+ + G +++ DFG LA + N + V T + AP+V+ Sbjct: 135 RNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAPEVM 194 Query: 181 MGSRTYSTSIDIWSCGCILAEMITG 205 R Y D+WS G E+ TG Sbjct: 195 EQVRGYDFKADMWSFGITAIELATG 219 >3RAW-A nrPDB Length = 381 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 87/329 (26%), Positives = 146/329 (44%), Gaps = 60/329 (18%) Query: 13 LGNGTYATVYKGLNKTTG-VYVALKEVKLDSEEGTPSTAIR-EISLMKELKHEN------ 64 LG GT+ V + L+ G VALK ++ G A R EI+++K++K ++ Sbjct: 59 LGEGTFGKVVECLDHARGKSQVALKIIR---NVGKYREAARLEINVLKKIKEKDKENKFL 115 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 V + D + + + FE + + +++ P L V++ +QL L F Sbjct: 116 CVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYP----LPHVRHMAYQLCHALRFL 171 Query: 125 HENKILHRDLKPQNLL-IN------------------KRGQLKLGDFGLARAFGIPVNTF 165 HEN++ H DLKP+N+L +N K +++ DFG A TF Sbjct: 172 HENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA--------TF 223 Query: 166 SSE-----VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKL 220 E V T YR P+V++ ++ D+WS GCIL E G LF + E L + Sbjct: 224 DHEHHTTIVATRHYRPPEVIL-ELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVM 282 Query: 221 IFDIMGTPNESLWPSVTKLPKY----------NPNIQQRPPRDLRQVLQPHTKEPLDG-N 269 + I+G P S T+ KY N + + + + + ++ L+ Sbjct: 283 MEKILG-PIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQ 341 Query: 270 LMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 L D + +L+ +P R++ +AL HP+FA Sbjct: 342 LFDLMRRMLEFDPAQRITLAEALLHPFFA 370 >3IO7-A nrPDB Length = 313 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 79/283 (27%), Positives = 139/283 (49%), Gaps = 45/283 (15%) Query: 6 QFKQLEKLGNGTYATV----YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 K L++LG G + +V Y L TG VA+K+++ +EE REI ++K L+ Sbjct: 29 HLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE-REIEILKSLQ 87 Query: 62 HENIVRLYDVIHTENK--LTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 H+NIV+ V ++ + L L+ E++ L+ Y+ + R + L++Y Q+ Sbjct: 88 HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQK----HKERIDHIKLLQYTS-QIC 142 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS----SEVVTLWY 174 +G+ + + +HRDL +N+L+ ++K+GDFGL + + E WY Sbjct: 143 KGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY 202 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMIT--GKPLFPGT-------NDEEQLKLIFDIM 225 AP+ L S+ +S + D+WS G +L E+ T K P ND++ ++F ++ Sbjct: 203 -APESLTESK-FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLI 260 Query: 226 -------------GTPNESLWPSVTKLPKYNPNIQQRPP-RDL 254 G P+E ++ +T+ +N N+ QRP RDL Sbjct: 261 ELLKNNGRLPRPDGCPDE-IYMIMTEC--WNNNVNQRPSFRDL 300 >5UIU-A nrPDB Length = 323 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 68/200 (34%), Positives = 98/200 (49%), Gaps = 9/200 (4%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLD-SEEGTPSTAIREISLMKELKHENIVRLYD 70 K+G G + VYKG T V V +D + E +EI +M + +HEN+V L Sbjct: 54 KMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLG 113 Query: 71 VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 + L LV+ +M N +D + + L ++ G+ F HEN + Sbjct: 114 FSSDGDDLCLVYVYMPN--GSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHI 171 Query: 131 HRDLKPQNLLINKRGQLKLGDFGLARA---FGIPVNTFSSEVVTLWYRAPDVLMGSRTYS 187 HRD+K N+L+++ K+ DFGLARA F V T S V T Y AP+ L G T Sbjct: 172 HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMT-SRIVGTTAYMAPEALRGEITPK 230 Query: 188 TSIDIWSCGCILAEMITGKP 207 + DI+S G +L E+ITG P Sbjct: 231 S--DIYSFGVVLLEIITGLP 248 >2W1I-A nrPDB Length = 326 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 79/282 (28%), Positives = 139/282 (49%), Gaps = 45/282 (15%) Query: 7 FKQLEKLGNGTYATV----YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 K L++LG G + +V Y L TG VA+K+++ +EE REI ++K L+H Sbjct: 43 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE-REIEILKSLQH 101 Query: 63 ENIVRLYDVIHTENK--LTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 +NIV+ V ++ + L L+ E++ L+ Y+ + R + L++Y Q+ + Sbjct: 102 DNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQK----HKERIDHIKLLQYTS-QICK 156 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS----SEVVTLWYR 175 G+ + + +HRDL +N+L+ ++K+GDFGL + + E WY Sbjct: 157 GMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY- 215 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMIT--GKPLFPGT-------NDEEQLKLIFDIM- 225 AP+ L S+ +S + D+WS G +L E+ T K P ND++ ++F ++ Sbjct: 216 APESLTESK-FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE 274 Query: 226 ------------GTPNESLWPSVTKLPKYNPNIQQRPP-RDL 254 G P+E ++ +T+ +N N+ QRP RDL Sbjct: 275 LLKNNGRLPRPDGCPDE-IYMIMTEC--WNNNVNQRPSFRDL 313 >3UC3-A nrPDB Length = 361 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 66/218 (30%), Positives = 109/218 (50%), Gaps = 12/218 (5%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 M S ++ ++ +G+G + +K T VA+K ++ + REI + L Sbjct: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGA--AIDENVQREIINHRSL 73 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +H NIVR +VI T L ++ E+ + Y + N R E + ++F QLL G Sbjct: 74 RHPNIVRFKEVILTPTHLAIIMEYASGG-ELY---ERICNAGRFSE-DEARFFFQQLLSG 128 Query: 121 LAFCHENKILHRDLKPQNLLINKR--GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 +++CH +I HRDLK +N L++ +LK+ DFG +++ + + S V T Y AP+ Sbjct: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPE 187 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEE 216 VL+ D+WSCG L M+ G +P + EE Sbjct: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGA--YPFEDPEE 223 >2X7G-A nrPDB Length = 389 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 94/368 (25%), Positives = 157/368 (42%), Gaps = 84/368 (22%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 + ++ + KLG G ++TV+ + +VA+K VK S + TA+ EI L+K ++ Sbjct: 30 NGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK--SAQHYTETALDEIKLLKCVRES 87 Query: 64 N--------IVRLYDVIHTEN----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVK 111 + +V+L D + +VFE + + L K++ + + +GL + VK Sbjct: 88 DPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWI----IKSNYQGLPVRCVK 143 Query: 112 YFQWQLLQGLAFCHEN-KILHRDLKPQNLLI-----------------NKRG-------- 145 Q+LQGL + H KI+H D+KP+N+L+ K G Sbjct: 144 SIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSA 203 Query: 146 ----------------------QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 ++K+ D G A F+ ++ T YR+ +VL+G+ Sbjct: 204 VSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVH---KHFTEDIQTRQYRSIEVLIGA 260 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPG------TNDEEQLKLIFDIMGT-PNESLWPSV 236 YST DIWS C+ E+ TG LF + DE+ + I +++G+ P Sbjct: 261 -GYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGK 319 Query: 237 TKLPKYN-----PNIQQRPPRDLRQVLQPHTKEPLD--GNLMDFLHGLLQLNPDMRLSAK 289 +N +I + P L VL P + DFL +L++ P+ R SA Sbjct: 320 YSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAG 379 Query: 290 QALHHPWF 297 + L HPW Sbjct: 380 ECLRHPWL 387 >5YV8-A nrPDB Length = 298 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 79/321 (24%), Positives = 141/321 (43%), Gaps = 67/321 (20%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV---KLDSEEG---------------- 45 +Q+ +++G G+Y V N+ Y A+K + KL + G Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 46 --TPSTAI----REISLMKELKHENIVRLYDVIH--TENKLTLVFEFMDNDLKKYMDSRT 97 P I +EI+++K+L H N+V+L +V+ E+ L +VFE ++ M+ T Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVPT 130 Query: 98 VGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARA 157 + + L + +++ L++G+ + H KI+HRD+KP NLL+ + G +K+ DFG++ Sbjct: 131 L----KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE 186 Query: 158 FGIPVNTFSSEVVTLWYRAPDVLMGSRTY--STSIDIWSCGCILAEMITGKPLFPGTNDE 215 F S+ V T + AP+ L +R ++D+W+ G L + G+ F DE Sbjct: 187 FKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF---MDE 243 Query: 216 EQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLH 275 + L + + + P QP E +L D + Sbjct: 244 RIMCL--------HSKIKSQALEFPD-----------------QPDIAE----DLKDLIT 274 Query: 276 GLLQLNPDMRLSAKQALHHPW 296 +L NP+ R+ + HPW Sbjct: 275 RMLDKNPESRIVVPEIKLHPW 295 >4CSV-A nrPDB Length = 275 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 65/218 (29%), Positives = 113/218 (51%), Gaps = 20/218 (9%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA--IREISLMKELKHENIVRLY 69 KLG+G + VY+G + + VA+K +K EGT S ++E +MK+LKH N+V+LY Sbjct: 18 KLGSGQFGEVYEGKWRNYNIEVAVKTLK----EGTMSVEEFLQEAQIMKKLKHPNLVQLY 73 Query: 70 DVIHTENKLTLVFEFMDN----DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 V E + ++ E+M + D + + TV N L++ Q+ G+A+ Sbjct: 74 GVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTV-NAQALLDMAA------QVASGMAYLE 126 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV-VTLWYRAPDVLMGSR 184 +HRDL +N L+ + +K+ DFGLAR T + + + AP+ + +R Sbjct: 127 SQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAISYNR 186 Query: 185 TYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 +S D+W+ G +L E+ T G+ +PG + E ++ + Sbjct: 187 -FSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQV 223 >4M7I-A nrPDB Length = 299 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 64/246 (26%), Positives = 119/246 (48%), Gaps = 36/246 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 + F+ ++ LG G + V++ NK A+K ++L + E +RE+ + +L+H Sbjct: 5 TDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 64 Query: 65 IVRLYDVIHTEN----------KLTLVFEFM---DNDLKKYMDSR-TVGNTPRGLELNLV 110 IVR ++ +N K+ L + +LK +M+ R T+ R + L++ Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124 Query: 111 KYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFG---------IP 161 Q+ + + F H ++HRDLKP N+ +K+GDFGL A P Sbjct: 125 ----LQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTP 180 Query: 162 VNTFS---SEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQL 218 + ++ +V T Y +P+ + G+ +YS +DI+S G IL E+ L+P + E++ Sbjct: 181 MPAYARHTGQVGTKLYMSPEQIHGN-SYSHKVDIFSLGLILFEL-----LYPFSTQMERV 234 Query: 219 KLIFDI 224 + + D+ Sbjct: 235 RTLTDV 240 >3QA8-A nrPDB Length = 676 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 68/215 (31%), Positives = 112/215 (52%), Gaps = 24/215 (11%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR---EISLMKELKHENIVR 67 E+LG G + V + +++ TG VA+K+ + +E +P R EI +MK+L H N+V Sbjct: 20 ERLGTGGFGYVLRWIHQDTGEQVAIKQCR---QELSPKNRERWCLEIQIMKKLNHPNVVS 76 Query: 68 LYDVIHTENKLT------LVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +V KL L E+ + DL+KY++ GL+ ++ + Sbjct: 77 AREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQ---FENCCGLKEGPIRTLLSDISSA 133 Query: 121 LAFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFGIPVNTFSSEVV-TLWYRA 176 L + HEN+I+HRDLKP+N+++ +R K+ D G A+ + +E V TL Y A Sbjct: 134 LRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKE--LDQGELCTEFVGTLQYLA 191 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITG-KPLFP 210 P+ L+ + Y+ ++D WS G + E ITG +P P Sbjct: 192 PE-LLEQKKYTVTVDYWSFGTLAFECITGFRPFLP 225 >6DBN-A nrPDB Length = 316 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 66/212 (31%), Positives = 108/212 (50%), Gaps = 24/212 (11%) Query: 7 FKQLEKLGNGTYATV----YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 K++ LG G + V Y TG VA+K +K +S + +EI +++ L H Sbjct: 37 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYH 96 Query: 63 ENIVRLYDVIHTE---NKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQW--Q 116 ENIV+ Y I TE N + L+ EF+ LK+Y+ ++NL + ++ Q Sbjct: 97 ENIVK-YKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKN-------KINLKQQLKYAVQ 148 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS----SEVVTL 172 + +G+ + + +HRDL +N+L+ Q+K+GDFGL +A ++ + Sbjct: 149 ICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVF 208 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT 204 WY AP+ LM S+ Y S D+WS G L E++T Sbjct: 209 WY-APECLMQSKFYIAS-DVWSFGVTLHELLT 238 >4KIK-B nrPDB Length = 677 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 69/217 (31%), Positives = 107/217 (49%), Gaps = 28/217 (12%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR---EISLMKELKHENIVR 67 E+LG G + V + N+ TG +A+K+ + +E +P R EI +M+ L H N+V Sbjct: 25 ERLGTGGFGNVIRWHNQETGEQIAIKQCR---QELSPRNRERWCLEIQIMRRLTHPNVVA 81 Query: 68 LYDVIHTENKLT------LVFEFMD-NDLKKYMDS-RTVGNTPRGLELNLVKYFQWQLLQ 119 DV L L E+ DL+KY++ G L L+ + Sbjct: 82 ARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLS----DIAS 137 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQL---KLGDFGLARAF--GIPVNTFSSEVVTLWY 174 L + HEN+I+HRDLKP+N+++ + Q K+ D G A+ G +F V TL Y Sbjct: 138 ALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSF---VGTLQY 194 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITG-KPLFP 210 AP+ L+ + Y+ ++D WS G + E ITG +P P Sbjct: 195 LAPE-LLEQQKYTVTVDYWSFGTLAFECITGFRPFLP 230 >3ORZ-A nrPDB Length = 316 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 64/230 (27%), Positives = 113/230 (49%), Gaps = 22/230 (9%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALK--EVKLDSEEGTPSTAIREISLMKELKHEN 64 FK + LG G+++TV T A+K E + +E RE +M L H Sbjct: 39 FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPF 98 Query: 65 IVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 V+LY + KL + N +L KY+ R +G+ + +++ +++ L + Sbjct: 99 FVKLYFCFQDDEKLYFGLSYAKNGELLKYI--RKIGS----FDETCTRFYTAEIVSALEY 152 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFG-----IPVNTFSSEVVTLWYRAPD 178 H I+HRDLKP+N+L+N+ +++ DFG A+ N+F V T Y +P+ Sbjct: 153 LHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSF---VGTAQYVSPE 209 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTND----EEQLKLIFDI 224 L+ ++ S D+W+ GCI+ +++ G P F N+ ++ +KL +D Sbjct: 210 -LLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDF 258 >3HDN-A nrPDB Length = 373 Score = 88.2 bits (217), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 67/241 (27%), Positives = 120/241 (49%), Gaps = 17/241 (7%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVK----LDSEEGTPSTAIREISLM 57 + S F L+ +G G++ V +K V+ A+K ++ L +E + R + L+ Sbjct: 35 AKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNV-LL 93 Query: 58 KELKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 K +KH +V L+ T +KL V ++++ +L ++ PR +++ + Sbjct: 94 KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRA------RFYAAE 147 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 + L + H I++RDLKP+N+L++ +G + L DFGL + +T S+ T Y A Sbjct: 148 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 207 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P+VL + Y ++D W G +L EM+ G P F N E +I+ P + L P++ Sbjct: 208 PEVLH-KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYD---NILNKPLQ-LKPNI 262 Query: 237 T 237 T Sbjct: 263 T 263 >2DQ7-X nrPDB Length = 283 Score = 87.4 bits (215), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 66/217 (30%), Positives = 117/217 (53%), Gaps = 16/217 (7%) Query: 10 LEKLGNGTYATVYKGL-NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRL 68 +++LGNG + V+ G N T V A+K +K + +P + + E +MK+LKH+ +V+L Sbjct: 14 IKRLGNGQFGEVWMGTWNGNTKV--AIKTLKPGTM--SPESFLEEAQIMKKLKHDKLVQL 69 Query: 69 YDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 Y V+ +E + +V E+M+ +D G R L+L + Q+ G+A+ Sbjct: 70 YAVV-SEEPIYIVTEYMNKG--SLLDFLKDGEG-RALKLPNLVDMAAQVAAGMAYIERMN 125 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE---VVTLWYRAPDVLMGSRT 185 +HRDL+ N+L+ K+ DFGLAR I N +++ + + AP+ + R Sbjct: 126 YIHRDLRSANILVGNGLICKIADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR- 182 Query: 186 YSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 ++ D+WS G +L E++T G+ +PG N+ E L+ + Sbjct: 183 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV 219 >3UDB-A nrPDB Length = 317 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 105/218 (48%), Gaps = 12/218 (5%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 M S +++ ++ +G G + +K VA+K + + E REI + L Sbjct: 15 MHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYI--ERGEKIDENVKREIINHRSL 72 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +H NIVR +VI T L +V E+ + N R E + ++F QL+ G Sbjct: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGEL----FERICNAGRFSE-DEARFFFQQLISG 127 Query: 121 LAFCHENKILHRDLKPQNLLINKR--GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 +++ H ++ HRDLK +N L++ +LK+ DFG ++A + + S V T Y AP+ Sbjct: 128 VSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKA-SVLHSQPKSAVGTPAYIAPE 186 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEE 216 VL+ D+WSCG L M+ G +P + EE Sbjct: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGA--YPFEDPEE 222 >1U54-B nrPDB Length = 291 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 73/231 (31%), Positives = 114/231 (49%), Gaps = 29/231 (12%) Query: 7 FKQLEKLGNGTYATVYKG-LNKTTG--VYVALKEVKLD--SEEGTPSTAIREISLMKELK 61 + LEKLG+G++ V +G + +G V VA+K +K D S+ IRE++ M L Sbjct: 20 LRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLD 79 Query: 62 HENIVRLYDVIHTE-----NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 H N++RLY V+ T +L + +D L+K+ +G R + Q Sbjct: 80 HRNLIRLYGVVLTPPMKMVTELAPLGSLLDR-LRKHQGHFLLGTLSR---------YAVQ 129 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN-----TFSSEVVT 171 + +G+ + + +HRDL +NLL+ R +K+GDFGL RA +P N V Sbjct: 130 VAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA--LPQNDDHYVMQEHRKVP 187 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 + AP+ L +RT+S + D W G L EM T G+ + G N + L I Sbjct: 188 FAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKI 237 >5MJB-A nrPDB Length = 305 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 58/202 (28%), Positives = 104/202 (51%), Gaps = 13/202 (6%) Query: 11 EKLGNGTYATVYKGLNKTTG---VYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVR 67 E +G G + VYKG K G +YVA+K +K E + E S+M + H NI+R Sbjct: 32 EVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRNIIR 91 Query: 68 LYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 L V+ + ++ EFM+N +DS N + + LV + + G+ + E Sbjct: 92 LEGVVTKSRPVMIITEFMEN---CALDSFLRQNDGQFTVIQLVGMLR-GIAAGMKYLSEM 147 Query: 128 KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN--TFSSEV---VTLWYRAPDVLMG 182 +HRDL +N+L+N K+ DFGL+R + T++S + + + + AP+ + Sbjct: 148 NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAI-A 206 Query: 183 SRTYSTSIDIWSCGCILAEMIT 204 R ++++ D+WS G ++ E+++ Sbjct: 207 YRKFTSASDVWSYGIVMWEVMS 228 >3ZUT-A nrPDB Length = 362 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 107/218 (49%), Gaps = 12/218 (5%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 M S +++ ++ +G+G + +K + VA+K + + E REI + L Sbjct: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREIINHRSL 72 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +H NIVR +VI T L +V E+ + N R E + ++F QL+ G Sbjct: 73 RHPNIVRFKEVILTPTHLAIVMEYASGGEL----FERICNAGRFSE-DEARFFFQQLISG 127 Query: 121 LAFCHENKILHRDLKPQNLLINKR--GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 +++CH ++ HRDLK +N L++ +LK+ FG +++ + + S V T Y AP+ Sbjct: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKS-SVLHSQPKSTVGTPAYIAPE 186 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEE 216 VL+ D+WSCG L M+ G +P + EE Sbjct: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGA--YPFEDPEE 222 >4OLI-A nrPDB Length = 645 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 62/209 (29%), Positives = 101/209 (48%), Gaps = 20/209 (9%) Query: 7 FKQLEKLGNGTYATV----YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 K++ LG G + V Y N TG VA+K +K D S +EI +++ L H Sbjct: 355 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYH 414 Query: 63 ENIVRLYDVI--HTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 E+I++ E L LV E++ L+ Y+ ++G L + F Q+ + Sbjct: 415 EHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIG-------LAQLLLFAQQICE 467 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF----SSEVVTLWYR 175 G+A+ H +HR+L +N+L++ +K+GDFGLA+A + + WY Sbjct: 468 GMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY- 526 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMIT 204 AP+ L + Y S D+WS G L E++T Sbjct: 527 APECLKEYKFYYAS-DVWSFGVTLYELLT 554 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 76/330 (23%), Positives = 131/330 (39%), Gaps = 66/330 (20%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE--------GTPSTAIREI--- 54 + QL LG GT VY+G + G +E K+D E+ G + ++ Sbjct: 46 EITQLSHLGQGTRTNVYEGRLRVEGSGDP-EEGKMDDEDPLVPGRDRGQELRVVLKVLDP 104 Query: 55 -------------SLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNT 101 SLM ++ H ++ ++ V + +V E++++ R G+ Sbjct: 105 SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHV 164 Query: 102 PRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQ-------LKLGDFGL 154 P ++ + + QL L++ ++H ++ +N+L+ + G +KL D G+ Sbjct: 165 PMAWKMVVAQ----QLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGV 220 Query: 155 ARAFGIPVNTFSSEVVTLWYRAPDVL-MGSRTYSTSIDIWSCGCILAEMI-TGKPLFPGT 212 G+ + V + + AP+ L G+ + ST++D W G L E+ G+ Sbjct: 221 ----GLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSR 276 Query: 213 NDEEQLKLIFDIMGTPNESLWPSVTKLPK----YNPNIQQRPP-----RDLRQVLQPHTK 263 + E+ P S P + L Y P QRP RDL + LQPH Sbjct: 277 SPSEKEHFYQRQHRLPEPSC-PQLATLTSQCLTYEPT--QRPSFRTILRDLTR-LQPH-- 330 Query: 264 EPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 NL D +L +NPD S H Sbjct: 331 -----NLAD----VLTVNPDSPASDPTVFH 351 >4HZS-A nrPDB Length = 341 Score = 86.3 bits (212), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 73/231 (31%), Positives = 114/231 (49%), Gaps = 29/231 (12%) Query: 7 FKQLEKLGNGTYATVYKG-LNKTTG--VYVALKEVKLD--SEEGTPSTAIREISLMKELK 61 + LEKLG+G++ V +G + +G V VA+K +K D S+ IRE++ M L Sbjct: 14 LRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLD 73 Query: 62 HENIVRLYDVIHTE-----NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 H N++RLY V+ T +L + +D L+K+ +G R + Q Sbjct: 74 HRNLIRLYGVVLTPPMKMVTELAPLGSLLDR-LRKHQGHFLLGTLSR---------YAVQ 123 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN-----TFSSEVVT 171 + +G+ + + +HRDL +NLL+ R +K+GDFGL RA +P N V Sbjct: 124 VAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRA--LPQNDDHYVMQEHRKVP 181 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 + AP+ L +RT+S + D W G L EM T G+ + G N + L I Sbjct: 182 FAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKI 231 >6DBM-A nrPDB Length = 318 Score = 86.3 bits (212), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 62/209 (29%), Positives = 101/209 (48%), Gaps = 20/209 (9%) Query: 7 FKQLEKLGNGTYATV----YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 K++ LG G + V Y N TG VA+K +K D+ S +EI +++ L H Sbjct: 33 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYH 92 Query: 63 ENIVRLYDVIHTEN--KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 E+I++ L LV E++ L+ Y+ ++G L + F Q+ + Sbjct: 93 EHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIG-------LAQLLLFAQQICE 145 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF----SSEVVTLWYR 175 G+A+ H +HRDL +N+L++ +K+GDFGLA+A + + WY Sbjct: 146 GMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY- 204 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMIT 204 AP+ L + Y S D+WS G L E++T Sbjct: 205 APECLKEYKFYYAS-DVWSFGVTLYELLT 232 >5FET-A nrPDB Length = 847 Score = 85.5 bits (210), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 70/220 (31%), Positives = 112/220 (50%), Gaps = 22/220 (10%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPS-TAIREISLMKELKHEN----IVR 67 +G GT+ TV +K T + ALK V S+ S I L +E+ EN I+R Sbjct: 541 IGRGTFGTVKLVHHKPTQIRYALKCV---SKRSIISLNQQNNIKLEREITAENDHPFIIR 597 Query: 68 LYDVIHTENKLTLVFEFMDNDLKKYMDSRTVG--NTPRGLELNLVKYFQWQLLQGLAFCH 125 L N + E + + Y R +G + P+ +++ ++ + + H Sbjct: 598 LVRTFKDSNCFYFLTELVTGG-ELYDAIRKLGLLSKPQA------QFYLGSIILAIEYLH 650 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 E I++RDLKP+N+L++K+G +KL DFG A+ T V T Y AP+V++G + Sbjct: 651 ERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTL---VGTPHYMAPEVILG-KG 706 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIM 225 Y ++DIW+ G L E I G PL G + E+QL++ DI+ Sbjct: 707 YGCTVDIWALGVCLYEFICG-PLPFGNDQEDQLEIFRDIL 745 >5AMN-A nrPDB Length = 299 Score = 85.5 bits (210), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 111/227 (48%), Gaps = 24/227 (10%) Query: 13 LGNGTYATVYKGLN---KTTGVYVALKEVKLDSEEGTPSTA---IREISLMKELKHENIV 66 LG G + V K K Y + VK+ E +PS + E +++K++ H +++ Sbjct: 31 LGEGEFGKVVKATAFHLKGRAGYTTVA-VKMLKENASPSELRDLLSEFNVLKQVNHPHVI 89 Query: 67 RLYDVIHTENKLTLVFEFMD-NDLKKYM-DSRTVGN---TPRGLELNLVKYFQWQLLQGL 121 +LY + L L+ E+ L+ ++ +SR VG R L + + F WQ+ QG+ Sbjct: 90 KLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQISQGM 149 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 + E K++HRDL +N+L+ + ++K+ DFGL+R V S V R P M Sbjct: 150 QYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRD----VYEEDSYVKRSQGRIPVKWM 205 Query: 182 GSRT-----YSTSIDIWSCGCILAEMIT--GKPLFPGTNDEEQLKLI 221 + Y+T D+WS G +L E++T G P +PG E L+ Sbjct: 206 AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP-YPGIPPERLFNLL 251 >5DYK-A nrPDB Length = 853 Score = 85.5 bits (210), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 69/224 (30%), Positives = 112/224 (50%), Gaps = 30/224 (13%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 72 +G GT+ TV +K T + ALK V S + L +N ++L I Sbjct: 547 IGRGTFGTVKLVHHKPTKIRYALKCVSKRS--------------IINLNQQNNIKLEREI 592 Query: 73 HTENK----LTLVFEFMDNDLKKYMDSRTVG----NTPRGLEL---NLVKYFQWQLLQGL 121 EN + LV F D+ ++ G + R L L + +++ ++ + Sbjct: 593 TAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAI 652 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 + HE I++RDLKP+N+L++K+G +KL DFG A+ T V T Y AP+V++ Sbjct: 653 EYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTL---VGTPHYMAPEVIL 709 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIM 225 G + Y ++DIW+ G L E I G PL G ++E+QL++ DI+ Sbjct: 710 G-KGYGCTVDIWALGICLYEFICG-PLPFGNDEEDQLEIFRDIL 751 >6F3F-A nrPDB Length = 455 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 66/215 (30%), Positives = 113/215 (52%), Gaps = 16/215 (7%) Query: 12 KLGNGTYATVYKGL-NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 KLG G + V+ G N TT VA+K +K + +P ++E +MK+L+HE +V+LY Sbjct: 194 KLGQGCFGEVWMGTWNGTT--RVAIKTLKPGTM--SPEAFLQEAQVMKKLRHEKLVQLYA 249 Query: 71 VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 V+ +E + +V E+M+ K + G T + L L + Q+ G+A+ + Sbjct: 250 VV-SEEPIYIVTEYMN---KGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYV 305 Query: 131 HRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV---VTLWYRAPDVLMGSRTYS 187 HRDL+ N+L+ + K+ DFGLAR I N +++ + + AP+ + R ++ Sbjct: 306 HRDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR-FT 362 Query: 188 TSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 D+WS G +L E+ T G+ +PG + E L + Sbjct: 363 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 397 >4XEY-B nrPDB Length = 408 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 64/215 (29%), Positives = 109/215 (50%), Gaps = 14/215 (6%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 KLG G Y VY+G+ K + VA+K +K D+ E ++E ++MKE+KH N+V+L V Sbjct: 132 KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME--VEEFLKEAAVMKEIKHPNLVQLLGV 189 Query: 72 IHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVK--YFQWQLLQGLAFCHENK 128 E ++ EFM +L Y+ R E+N V Y Q+ + + + Sbjct: 190 CTREPPFYIITEFMTYGNLLDYL--RECNRQ----EVNAVVLLYMATQISSAMEYLEKKN 243 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWYRAPDVLMGSRTYS 187 +HRDL +N L+ + +K+ DFGL+R G + + + AP+ L ++ +S Sbjct: 244 FIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK-FS 302 Query: 188 TSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 D+W+ G +L E+ T G +PG + + +L+ Sbjct: 303 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELL 337 >4NIF-A nrPDB Length = 333 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 79/298 (26%), Positives = 126/298 (42%), Gaps = 51/298 (17%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E +G G+Y+ + ++K T + A+K + D + PS I EI L++ +H NI+ L D Sbjct: 14 ETIGVGSYSECKRCVHKATNMEYAVKVI--DKSKRDPSEEI-EI-LLRYGQHPNIITLKD 69 Query: 71 VIHTENKLTLVFEFMDND--LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 V + LV E M L K + + L+ + + + + H Sbjct: 70 VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIG-------KTVEYLHSQG 122 Query: 129 ILHRDLKPQNLL-INKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 ++HRDLKP N+L +++ G L++ DFG A+ + T + AP+VL + Sbjct: 123 VVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK-RQ 181 Query: 185 TYSTSIDIWSCGCILAEMITGKPLF---PGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 Y DIWS G +L M+ G F P EE L I T + W +V++ K Sbjct: 182 GYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAK 241 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 D + +L ++P RL+AKQ L HPW + Sbjct: 242 ------------------------------DLVSKMLHVDPHQRLTAKQVLQHPWVTQ 269 >3ORP-A nrPDB Length = 311 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 105/219 (47%), Gaps = 19/219 (8%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR---EISLMKEL 60 S +++ E LG G + V+ + VA+K ++ D PS +R E L Sbjct: 11 SDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLAR-DPSFYLRFRREAQNAAAL 69 Query: 61 KHENIVRLYDVIHTENKLT----LVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQW 115 H IV +YD E +V E++D L+ + + R +E+ Sbjct: 70 NHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEV------IA 123 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF---GIPVNTFSSEVVTL 172 Q L F H+N I+HRD+KP N++I+ +K+ DFG+ARA G V ++ + T Sbjct: 124 DACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA 183 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG 211 Y +P+ G + S D++S GC+L E++TG+P F G Sbjct: 184 QYLSPEQARGDSVDARS-DVYSLGCVLYEVLTGEPPFTG 221 >2H8H-A nrPDB Length = 535 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 66/215 (30%), Positives = 112/215 (52%), Gaps = 16/215 (7%) Query: 12 KLGNGTYATVYKGL-NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 KLG G + V+ G N TT VA+K +K + +P ++E +MK+L+HE +V+LY Sbjct: 274 KLGQGCFGEVWMGTWNGTT--RVAIKTLKPGTM--SPEAFLQEAQVMKKLRHEKLVQLYA 329 Query: 71 VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 V+ +E + +V E+M K + G T + L L + Q+ G+A+ + Sbjct: 330 VV-SEEPIYIVTEYMS---KGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 385 Query: 131 HRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE---VVTLWYRAPDVLMGSRTYS 187 HRDL+ N+L+ + K+ DFGLAR I N +++ + + AP+ + R ++ Sbjct: 386 HRDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR-FT 442 Query: 188 TSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 D+WS G +L E+ T G+ +PG + E L + Sbjct: 443 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 477 >3A8W-A nrPDB Length = 345 Score = 84.7 bits (208), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 105/208 (50%), Gaps = 13/208 (6%) Query: 7 FKQLEKLGNGTYATVY-KGLNKTTGVYVALKEVK---LDSEEGTPSTAIREISLMKELKH 62 F L +G G+YA V L KT +Y A+K VK ++ +E + + H Sbjct: 11 FDLLRVIGRGSYAKVLLVRLKKTDRIY-AMKVVKKELVNDDEDIDWVQTEKHVFEQASNH 69 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +V L+ TE++L V E+++ DL +M + R L +++ ++ L Sbjct: 70 PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQ------RKLPEEHARFYSAEISLAL 123 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 + HE I++RDLK N+L++ G +KL D+G+ + P +T S+ T Y AP++L Sbjct: 124 NYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILR 183 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLF 209 G Y S+D W+ G ++ EM+ G+ F Sbjct: 184 GE-DYGFSVDWWALGVLMFEMMAGRSPF 210 >2JDO-A nrPDB Length = 342 Score = 84.7 bits (208), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 75/308 (24%), Positives = 135/308 (43%), Gaps = 59/308 (19%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALK----EVKLDSEEGTPSTAIREISLMK 58 + + F L+ LG GT+ V K TG Y A+K EV + +E + + E +++ Sbjct: 8 TMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDE--VAHTVTESRVLQ 65 Query: 59 ELKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 +H + L T ++L V E+ + +L ++ V R +++ ++ Sbjct: 66 NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERA------RFYGAEI 119 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLAR---AFGIPVNTFSSEVVTLWY 174 + L + H +++RD+K +NL+++K G +K+ DFGL + + G + TF T Y Sbjct: 120 VSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCG---TPEY 176 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 AP+VL + Y ++D W G ++ EM+ G+ F + E +LI Sbjct: 177 LAPEVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL------------ 223 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAK 289 + ++ P T P +L L GLL+ +P RL AK Sbjct: 224 -------------------MEEIRFPRTLSPEAKSL---LAGLLKKDPKQRLGGGPSDAK 261 Query: 290 QALHHPWF 297 + + H +F Sbjct: 262 EVMEHRFF 269 >6NPU-A nrPDB Length = 298 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 63/207 (30%), Positives = 105/207 (50%), Gaps = 14/207 (6%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 KLG G Y VY+G+ K + VA+K +K D+ E ++E ++MKE+KH N+V+L V Sbjct: 33 KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME--VEEFLKEAAVMKEIKHPNLVQLLGV 90 Query: 72 IHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVK--YFQWQLLQGLAFCHENK 128 E ++ EFM +L Y+ R E+N V Y Q+ + + + Sbjct: 91 CTREPPFYIITEFMTYGNLLDYL--RECNRQ----EVNAVVLLYMATQISSAMEYLEKKN 144 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWYRAPDVLMGSRTYS 187 +HRDL +N L+ + +K+ DFGL+R G + + + AP+ L ++ +S Sbjct: 145 FIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK-FS 203 Query: 188 TSIDIWSCGCILAEMIT-GKPLFPGTN 213 D+W+ G +L E+ T G +PG + Sbjct: 204 IKSDVWAFGVLLWEIATYGMSPYPGID 230 >3NYO-A nrPDB Length = 576 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 105/211 (49%), Gaps = 11/211 (5%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGT--PSTAIREISLMKEL 60 + + F+Q LG G + V + TG A K+++ + + A+ E +++++ Sbjct: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 +V L T++ L LV M+ DLK ++ P + ++ ++ Sbjct: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAV----FYAAEICC 297 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPV-NTFSSEVVTLWYRAPD 178 GL H +I++RDLKP+N+L++ G +++ D GL A +P T V T+ Y AP+ Sbjct: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGTVGYMAPE 355 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLF 209 V+ R Y+ S D W+ GC+L EMI G+ F Sbjct: 356 VVKNER-YTFSPDWWALGCLLYEMIAGQSPF 385 >2PSQ-A nrPDB Length = 370 Score = 84.3 bits (207), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 67/232 (28%), Positives = 111/232 (47%), Gaps = 25/232 (10%) Query: 13 LGNGTYATVYK----GLNK---TTGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHEN 64 LG G + V G++K V VA+K +K D+ E S + E+ +MK + KH+N Sbjct: 89 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 148 Query: 65 IVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQ--------- 114 I+ L + L ++ E+ +L++Y+ +R ++N V Q Sbjct: 149 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 208 Query: 115 -WQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFG---IPVNTFSSEVV 170 +QL +G+ + K +HRDL +N+L+ + +K+ DFGLAR T + + Sbjct: 209 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 268 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 W AP+ L R Y+ D+WS G ++ E+ T G +PG EE KL+ Sbjct: 269 VKWM-APEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 318 >6J5U-C nrPDB Length = 426 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 72/235 (30%), Positives = 120/235 (51%), Gaps = 22/235 (9%) Query: 2 SSSSQFKQLEKLGNGTYATVYKG-LNKTT--------GVYVALKEVKLDSEEGTPSTAIR 52 +++ F+Q LG G + V+KG +++T+ G+ VA+K++K + +G + Sbjct: 81 NATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGH-KEWLT 139 Query: 53 EISLMKELKHENIVRLYD-VIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLV 110 E++ + +L H N+V L EN+L LV+EFM L+ ++ R G P L + Sbjct: 140 EVNYLGQLSHPNLVLLVGYCAEGENRL-LVYEFMPKGSLENHLFRR--GAQP--LTWAIR 194 Query: 111 KYFQWQLLQGLAFCHENK--ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE 168 +GL F HE K +++RD K N+L++ KL DFGLA+A NT S Sbjct: 195 MKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVST 254 Query: 169 VV--TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLI 221 V T Y AP+ + R + S D++S G +L E+I+G+ +N + L+ Sbjct: 255 KVIGTHGYAAPEYVATGRLTAKS-DVYSFGVVLLELISGRRAMDNSNGGNEYSLV 308 >2XYN-A nrPDB Length = 292 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 106/216 (49%), Gaps = 12/216 (5%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 KLG G Y VY G+ K + VA+K +K D+ E ++E ++MKE+KH N+V+L V Sbjct: 39 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME--VEEFLKEAAVMKEIKHPNLVQLLGV 96 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 E +V E+M +D N + L+ Y Q+ + + + +H Sbjct: 97 CTLEPPFYIVTEYMP--YGNLLDYLRECNREEVTAVVLL-YMATQISSAMEYLEKKNFIH 153 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSI 190 RDL +N L+ + +K+ DFGL+R G + + + AP+ L T+S Sbjct: 154 RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL-AYNTFSIKS 212 Query: 191 DIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIM 225 D+W+ G +L E+ T G +PG + L ++D++ Sbjct: 213 DVWAFGVLLWEIATYGMSPYPGID----LSQVYDLL 244 >3TXO-A nrPDB Length = 353 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 61/238 (25%), Positives = 111/238 (46%), Gaps = 22/238 (9%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD---SEEGTPSTAIREISLMKELK 61 F+ + LG G++ V K TG A+K +K D ++ T + L Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H + +L+ T ++L V EF++ DL ++ + R +++ +++ Sbjct: 83 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARA------RFYAAEIISA 136 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLAR---AFGIPVNTFSSEVVTLWYRAP 177 L F H+ I++RDLK N+L++ G KL DFG+ + G+ TF T Y AP Sbjct: 137 LMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCG---TPDYIAP 193 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 ++L Y ++D W+ G +L EM+ G F N+++ + I + +E ++P+ Sbjct: 194 EILQ-EMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN-----DEVVYPT 245 >1TKI-A nrPDB Length = 321 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 73/295 (24%), Positives = 131/295 (44%), Gaps = 48/295 (16%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLMKELKHENIVRLY 69 E LG G + V++ + ++ K VK+ +GT ++ EIS++ +H NI+ L+ Sbjct: 11 EDLGRGEFGIVHRCVETSSKKTYMAKFVKV---KGTDQVLVKKEISILNIARHRNILHLH 67 Query: 70 DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELN---LVKYFQWQLLQGLAFCHE 126 + + +L ++FEF+ +D NT ELN +V Y Q+ + L F H Sbjct: 68 ESFESMEELVMIFEFISG-----LDIFERINTS-AFELNEREIVSYVH-QVCEALQFLHS 120 Query: 127 NKILHRDLKPQNLLINKR--GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 + I H D++P+N++ R +K+ +FG AR P + F Y AP+V Sbjct: 121 HNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLK-PGDNFRLLFTAPEYYAPEVHQHD- 178 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 ST+ D+WS G ++ +++G F +++ ++ I + T +E + ++ Sbjct: 179 VVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISI------ 232 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 MDF+ LL R++A +AL HPW + Sbjct: 233 ------------------------EAMDFVDRLLVKERKSRMTASEALQHPWLKQ 263 >3DB8-A nrPDB Length = 317 Score = 84.0 bits (206), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 62/204 (30%), Positives = 94/204 (46%), Gaps = 18/204 (8%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEV------KLDSEEGTPSTAIREISLMKELKHENIV 66 LG G +A Y+ + T A K V K +E + EI++ K L + ++V Sbjct: 50 LGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMST----EIAIHKSLDNPHVV 105 Query: 67 RLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 + ++ + +V E L + R P +YF Q +QG+ + H Sbjct: 106 GFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEA------RYFMRQTIQGVQYLH 159 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 N+++HRDLK NL +N +K+GDFGLA T Y AP+VL + Sbjct: 160 NNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLC-KKG 218 Query: 186 YSTSIDIWSCGCILAEMITGKPLF 209 +S +DIWS GCIL ++ GKP F Sbjct: 219 HSFEVDIWSLGCILYTLLVGKPPF 242 >3A4O-X nrPDB Length = 286 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 116/222 (52%), Gaps = 25/222 (11%) Query: 7 FKQLEKLGNGTYATVYKGL-NKTTGVYVALKEVKLDSEEGTPSTA--IREISLMKELKHE 63 K +++LG G + V+ G N +T V A+K +K GT S + E +LMK L+H+ Sbjct: 15 IKLVKRLGAGQFGEVWMGYYNNSTKV--AVKTLK----PGTMSVQAFLEEANLMKTLQHD 68 Query: 64 NIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNT--PRGLELNLVKYFQWQLLQG 120 +VRLY V+ E + ++ E+M L ++ S G P+ ++ F Q+ +G Sbjct: 69 KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLID------FSAQIAEG 122 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE---VVTLWYRAP 177 +A+ +HRDL+ N+L+++ K+ DFGLAR I N +++ + + AP Sbjct: 123 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARV--IEDNEYTAREGAKFPIKWTAP 180 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQL 218 + + ++ D+WS G +L E++T GK +PG + + + Sbjct: 181 EAI-NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVM 221 >4AT3-A nrPDB Length = 299 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 114/227 (50%), Gaps = 31/227 (13%) Query: 12 KLGNGTYATV-----YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 +LG G + V Y + + VA+K +K D+ + RE L+ L+HE+IV Sbjct: 20 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-DASDNARKDFHREAELLTNLQHEHIV 78 Query: 67 RLYDVIHTENKLTLVFEFMDN-DLKKYMDSR-------TVGNTPRGLELNLVKYFQWQLL 118 + Y V + L +VFE+M + DL K++ + GN P L + + + Q+ Sbjct: 79 KFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIA 138 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE--------VV 170 G+ + +HRDL +N L+ + +K+GDFG++R + +S++ ++ Sbjct: 139 AGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR------DVYSTDYYRVGGHTML 192 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GK-PLFPGTNDE 215 + + P+ +M R ++T D+WS G +L E+ T GK P + +N+E Sbjct: 193 PIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNE 238 >3MV5-A nrPDB Length = 342 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 77/305 (25%), Positives = 135/305 (44%), Gaps = 54/305 (17%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA--IREISLMKELKH 62 ++F+ L+ LG GT+ V K TG Y A+K +K + A + E +++ +H Sbjct: 10 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 69 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 + L T ++L V E+ + + SR R + +++ +++ L Sbjct: 70 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-----RVFSEDRARFYGAEIVSALD 124 Query: 123 FCH-ENKILHRDLKPQNLLINKRGQLKLGDFGLARAF---GIPVNTFSSEVVTLWYRAPD 178 + H E +++RDLK +NL+++K G +K+ DFGL + G + TF T Y AP+ Sbjct: 125 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPE 181 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL + Y ++D W G ++ EM+ G+ F + E+ +LI Sbjct: 182 VLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL---------------- 224 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS-----AKQALH 293 + ++ P T P +L L GLL+ +P RL AK+ + Sbjct: 225 ---------------MEEIRFPRTLGPEAKSL---LSGLLKKDPKQRLGGGSEDAKEIMQ 266 Query: 294 HPWFA 298 H +FA Sbjct: 267 HRFFA 271 >5KCV-A nrPDB Length = 460 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 77/305 (25%), Positives = 135/305 (44%), Gaps = 54/305 (17%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA--IREISLMKELKH 62 ++F+ L+ LG GT+ V K TG Y A+K +K + A + E +++ +H Sbjct: 162 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 221 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 + L T ++L V E+ + + SR R + +++ +++ L Sbjct: 222 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE-----RVFSEDRARFYGAEIVSALD 276 Query: 123 FCH-ENKILHRDLKPQNLLINKRGQLKLGDFGLARAF---GIPVNTFSSEVVTLWYRAPD 178 + H E +++RDLK +NL+++K G +K+ DFGL + G + TF T Y AP+ Sbjct: 277 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPE 333 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL + Y ++D W G ++ EM+ G+ F + E+ +LI Sbjct: 334 VLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL---------------- 376 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS-----AKQALH 293 + ++ P T P +L L GLL+ +P RL AK+ + Sbjct: 377 ---------------MEEIRFPRTLGPEAKSL---LSGLLKKDPKQRLGGGSEDAKEIMQ 418 Query: 294 HPWFA 298 H +FA Sbjct: 419 HRFFA 423 >5TQX-A nrPDB Length = 655 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 60/202 (29%), Positives = 99/202 (49%), Gaps = 10/202 (4%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E+LG G + V ++ + +A+K +L+ EI +MK+L H N+V+ D Sbjct: 14 ERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACD 73 Query: 71 VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPR---GLELNLVKYFQWQLLQGLAFCHEN 127 V N L + + D R + N P GL+ + + + G+ + HEN Sbjct: 74 VPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHEN 133 Query: 128 KILHRDLKPQNLLINKRGQL---KLGDFGLARAFGIPVNTFSSEVV-TLWYRAPDVLMGS 183 KI+HRDLKP+N+++ G K+ D G A+ + +E V TL Y AP+ L + Sbjct: 134 KIIHRDLKPENIVLQDVGGKIIHKIIDLGYAK--DVDQGELCTEFVGTLQYLAPE-LFEN 190 Query: 184 RTYSTSIDIWSCGCILAEMITG 205 + Y+ ++D WS G ++ E I G Sbjct: 191 KPYTATVDYWSFGTMVFECIAG 212 >5EG3-A nrPDB Length = 334 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 69/236 (29%), Positives = 115/236 (48%), Gaps = 33/236 (13%) Query: 13 LGNGTYATVYK----GLNKTT---GVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHEN 64 LG G + V G++K V VA+K +K D+ E S + E+ +MK + KH+N Sbjct: 43 LGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 102 Query: 65 IVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLEL----NLVKYFQ----- 114 I+ L + L ++ + +L++Y+ +R P G+EL N V Q Sbjct: 103 IINLLGACTQDGPLYVIVAYASKGNLREYLRARR----PPGMELSPDINRVPEEQMTFKD 158 Query: 115 -----WQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV 169 +QL +G+ + K +HRDL +N+L+ + +K+ DFGLAR ++ F Sbjct: 159 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN-NIDFFKETT 217 Query: 170 ---VTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 + + + AP+ L R Y+ D+WS G ++ E+ T G +PG EE KL+ Sbjct: 218 NGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 272 >2FO0-A nrPDB Length = 495 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 109/215 (50%), Gaps = 14/215 (6%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 KLG G Y VY+G+ K + VA+K +K D+ E ++E ++MKE+KH N+V+L V Sbjct: 224 KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME--VEEFLKEAAVMKEIKHPNLVQLLGV 281 Query: 72 IHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVK--YFQWQLLQGLAFCHENK 128 E ++ EFM +L Y+ R E+N V Y Q+ + + + Sbjct: 282 CTREPPFYIITEFMTYGNLLDYL--RECNRQ----EVNAVVLLYMATQISSAMEYLEKKN 335 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWYRAPDVLMGSRTYS 187 +HR+L +N L+ + +K+ DFGL+R G + + + AP+ L ++ +S Sbjct: 336 FIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK-FS 394 Query: 188 TSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 D+W+ G +L E+ T G +PG + + +L+ Sbjct: 395 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELL 429 >3LM0-A nrPDB Length = 327 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 73/296 (24%), Positives = 137/296 (46%), Gaps = 42/296 (14%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKH-ENIVRL 68 ++LG G +A V + ++K+TG A K +K + + + EI++++ K ++ L Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 94 Query: 69 YDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 ++V +++ L+ E+ + S + + N V Q+L+G+ + H+N Sbjct: 95 HEVYENTSEIILILEYAAGG---EIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNN 151 Query: 129 ILHRDLKPQNLLINK---RGQLKLGDFGLARAFGIPVNTFSSEVV-TLWYRAPDVLMGSR 184 I+H DLKPQN+L++ G +K+ DFG++R G E++ T Y AP++L Sbjct: 152 IVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACEL--REIMGTPEYLAPEIL-NYD 208 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 +T+ D+W+ G I ++T F G +++E I + +E + SV++L Sbjct: 209 PITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLAT--- 265 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 DF+ LL NP+ R +A+ L H W ++ Sbjct: 266 ---------------------------DFIQSLLVKNPEKRPTAEICLSHSWLQQW 294 >3DAK-A nrPDB Length = 290 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 59/205 (28%), Positives = 99/205 (48%), Gaps = 12/205 (5%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E +G+G A V VA+K + L+ + + ++EI M + H NIV Y Sbjct: 16 EVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYT 75 Query: 71 VIHTENKLTLVFEFMDN----DLKKYMDSRTVGNTPRG-LELNLVKYFQWQLLQGLAFCH 125 +++L LV + + D+ K++ ++ G G L+ + + ++L+GL + H Sbjct: 76 SFVVKDELWLVMKLLSGGSVLDIIKHIVAK--GEHKSGVLDESTIATILREVLEGLEYLH 133 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFG----LARAFGIPVNTFSSEVV-TLWYRAPDVL 180 +N +HRD+K N+L+ + G +++ DFG LA I N V T + AP+V+ Sbjct: 134 KNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVM 193 Query: 181 MGSRTYSTSIDIWSCGCILAEMITG 205 R Y DIWS G E+ TG Sbjct: 194 EQVRGYDFKADIWSFGITAIELATG 218 >4E20-A nrPDB Length = 290 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 98/209 (46%), Gaps = 20/209 (9%) Query: 7 FKQLEKLGNGTYATV----YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 K++ LG G + V Y N TG VA+K +K S REI +++ L H Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYH 69 Query: 63 ENIVRLYDVI--HTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 E+IV+ E + LV E++ L+ Y+ VG L + F Q+ + Sbjct: 70 EHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVG-------LAQLLLFAQQICE 122 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF----SSEVVTLWYR 175 G+A+ H +HR L +N+L++ +K+GDFGLA+A + + WY Sbjct: 123 GMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY- 181 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMIT 204 AP+ L + Y S D+WS G L E++T Sbjct: 182 APECLKECKFYYAS-DVWSFGVTLYELLT 209 >3KN6-A nrPDB Length = 325 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 72/293 (24%), Positives = 128/293 (43%), Gaps = 41/293 (13%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HENIVRLYDV 71 LG G+++ K ++K + A+K + E T +EI+ +K + H NIV+L++V Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQ----KEITALKLCEGHPNIVKLHEV 74 Query: 72 IHTENKLTLVFEFMDND--LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 H + LV E ++ ++ + T Y +L+ ++ H+ + Sbjct: 75 FHDQLHTFLVMELLNGGELFERIKKKKHFSETE-------ASYIMRKLVSAVSHMHDVGV 127 Query: 130 LHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 +HRDLKP+NLL N ++K+ DFG AR + TL Y AP+ L+ Y Sbjct: 128 VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LLNQNGY 186 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNI 246 S D+WS G IL M++G+ F + +IM K+ K + + Sbjct: 187 DESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIM-----------KKIKKGDFSF 235 Query: 247 QQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + +++ Q + D + GLL ++P+ RL ++ W + Sbjct: 236 EGEAWKNVSQEAK------------DLIQGLLTVDPNKRLKMSGLRYNEWLQD 276 >4RA4-A nrPDB Length = 355 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 59/226 (26%), Positives = 110/226 (48%), Gaps = 17/226 (7%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD---SEEGTPSTAIREISLMKELK 61 + F L LG G++ V K T A+K +K D ++ T + + L K Sbjct: 20 TDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDK 79 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 + +L+ T ++L V E+++ DL ++ P+ + ++ ++ G Sbjct: 80 PPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAV------FYAAEISIG 133 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF---GIPVNTFSSEVVTLWYRAP 177 L F H+ I++RDLK N++++ G +K+ DFG+ + G+ TF T Y AP Sbjct: 134 LFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCG---TPDYIAP 190 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFD 223 +++ + Y S+D W+ G +L EM+ G+P F G +++E + I + Sbjct: 191 EII-AYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME 235 >6GVJ-A nrPDB Length = 429 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 83/304 (27%), Positives = 137/304 (45%), Gaps = 58/304 (19%) Query: 10 LEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLMKELKH--ENIV 66 L+++G+G + V++ LN+ +Y A+K V L+ + + R EI+ + +L+ + I+ Sbjct: 149 LKQIGSGGSSKVFQVLNEKKQIY-AIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKII 207 Query: 67 RLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 RLYD T+ + +V E + DL ++ + + ++ K + +L+ + H+ Sbjct: 208 RLYDYEITDQYIYMVMECGNIDLNSWLKKK------KSIDPWERKSYWKNMLEAVHTIHQ 261 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVTLWYRAPDVL--MG 182 + I+H DLKP N LI G LKL DFG+A + S+V T+ Y P+ + M Sbjct: 262 HGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 320 Query: 183 SR--------TYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESL- 232 S S D+WS GCIL M GK P N +L I D PN + Sbjct: 321 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIID----PNHEIE 376 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 +P + P +DL+ D L L+ +P R+S + L Sbjct: 377 FPDI-------------PEKDLQ----------------DVLKCCLKRDPKQRISIPELL 407 Query: 293 HHPW 296 HP+ Sbjct: 408 AHPY 411 >3HMP-A nrPDB Length = 342 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 83/308 (26%), Positives = 138/308 (44%), Gaps = 58/308 (18%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLMKELKH--E 63 + L+++G+G + V++ LN+ +Y A+K V L+ + + R EI+ + +L+ + Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKKQIY-AIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 I+RLYD T+ + +V E + DL ++ + + ++ K + +L+ + Sbjct: 117 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKK------KSIDPWERKSYWKNMLEAVHT 170 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVTLWYRAPDVL- 180 H++ I+H DLKP N LI G LKL DFG+A + S+V T+ Y P+ + Sbjct: 171 IHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 229 Query: 181 -MGSR--------TYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNE 230 M S S D+WS GCIL M GK P N +L I D PN Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIID----PNH 285 Query: 231 SL-WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 + +P + P +DL+ D L L+ +P R+S Sbjct: 286 EIEFPDI-------------PEKDLQ----------------DVLKCCLKRDPKQRISIP 316 Query: 290 QALHHPWF 297 + L HP+ Sbjct: 317 ELLAHPYV 324 >4TPT-A nrPDB Length = 303 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 59/214 (27%), Positives = 108/214 (50%), Gaps = 29/214 (13%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E LG G + K +K TG + +KE+ + +E T T + E+ +M+ L H N+++ Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKEL-IRCDEETQKTFLTEVKVMRSLDHPNVLKFIG 64 Query: 71 VIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 V++ + KL L+ E+++ LK ++ R++ P ++ K + G+A+ H I Sbjct: 65 VLYKDKKLNLLTEYIEGGTLKDFL--RSMDPFPWQQKVRFAK----GIASGMAYLHSMCI 118 Query: 130 LHRDLKPQNLLINKRGQLKLGDFGLARAF-----GIPVNTFSSEVVTL------------ 172 +HRDL N LI + + DFGL+R P+ +++ TL Sbjct: 119 IHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVV 178 Query: 173 ---WYRAPDVLMGSRTYSTSIDIWSCGCILAEMI 203 ++ AP++L G ++Y ++DI+S G +L E+I Sbjct: 179 GNPYWMAPEMLNG-KSYDETVDIFSFGIVLCEII 211 >5SYS-A nrPDB Length = 286 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 64/215 (29%), Positives = 110/215 (51%), Gaps = 16/215 (7%) Query: 12 KLGNGTYATVYKGL-NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 KLG G + + G N TT VA+K +K + +P ++E +MK+L+HE +V+LY Sbjct: 25 KLGQGCFGECWMGTWNGTT--RVAIKTLKPGTM--SPEAFLQEAQVMKKLRHEKLVQLYA 80 Query: 71 VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 V+ +E + +V E+M K + G + L L + Q+ G+A+ + Sbjct: 81 VV-SEEPIYIVTEYMS---KGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYV 136 Query: 131 HRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV---VTLWYRAPDVLMGSRTYS 187 HRDL+ N+L+ + K+ DFGLAR I N +++ + + AP+ + R ++ Sbjct: 137 HRDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR-FT 193 Query: 188 TSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 D+WS G +L E+ T G+ +PG + E L + Sbjct: 194 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 228 >5AP3-A nrPDB Length = 313 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 83/307 (27%), Positives = 138/307 (44%), Gaps = 58/307 (18%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLMKELKH--E 63 + L+++G+G + V++ LN+ +Y A+K V L+ + + R EI+ + +L+ + Sbjct: 30 YSILKQIGSGGSSKVFQVLNEKKQIY-AIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 I+RLYD T+ + +V E + DL ++ + + ++ K + +L+ + Sbjct: 89 KIIRLYDYEITDQYIYMVMECGNIDLNGWLKKK------KSIDPWERKSYWKNMLEAVHT 142 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVTLWYRAPDVL- 180 H++ I+H DLKP N LI G LKL DFG+A + S+V T+ Y P+ + Sbjct: 143 IHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 201 Query: 181 -MGSR--------TYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNE 230 M S S D+WS GCIL M GK P N +L I D PN Sbjct: 202 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIID----PNH 257 Query: 231 SL-WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 + +P + P +DL+ D L L+ +P R+S Sbjct: 258 EIEFPDI-------------PEKDLQ----------------DVLKCCLKRDPKQRISIP 288 Query: 290 QALHHPW 296 + L HP+ Sbjct: 289 ELLAHPY 295 >5A46-A nrPDB Length = 386 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 35/237 (14%) Query: 13 LGNGTYATVY----KGLNKTTG---VYVALKEVKLDSEEGTPSTAIREISLMKEL-KHEN 64 LG G + V GL+K VA+K +K D+ E S I E+ +MK + KH+N Sbjct: 48 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 107 Query: 65 IVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLEL---------------N 108 I+ L + L ++ E+ +L++Y+ +R P GLE + Sbjct: 108 IINLLGACTQDGPLYVIVEYASKGNLREYLQARR----PPGLEYCYNPSHNPEEQLSSKD 163 Query: 109 LVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARA---FGIPVNTF 165 LV +Q+ +G+ + K +HRDL +N+L+ + +K+ DFGLAR T Sbjct: 164 LVS-CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTT 222 Query: 166 SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 + + W AP+ L R Y+ D+WS G +L E+ T G +PG EE KL+ Sbjct: 223 NGRLPVKWM-APEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL 277 >4PDO-A nrPDB Length = 299 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 64/233 (27%), Positives = 115/233 (49%), Gaps = 15/233 (6%) Query: 13 LGNGTYATVYKGLNKTTG----VYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRL 68 +G G + VYKG+ KT+ V VA+K +K E + E +M + H NI+RL Sbjct: 42 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRL 101 Query: 69 YDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 VI + ++ E+M+N L K++ + + L LV + + G+ + Sbjct: 102 EGVISKYKPMMIITEYMENGALDKFLREKDGEFSV----LQLVGMLR-GIAAGMKYLANM 156 Query: 128 KILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSE--VVTLWYRAPDVLMGSR 184 +HRDL +N+L+N K+ DFGL+R P T+++ + + + AP+ + R Sbjct: 157 NYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAI-SYR 215 Query: 185 TYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 ++++ D+WS G ++ E++T G+ + ++ E +K I D P PS Sbjct: 216 KFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSA 268 >3UIU-A nrPDB Length = 306 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 72/276 (26%), Positives = 130/276 (47%), Gaps = 45/276 (16%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 FK++E +G+G + V+K ++ G ++ VK ++E+ A RE+ + +L H NIV Sbjct: 14 FKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEK-----AEREVKALAKLDHVNIV 68 Query: 67 RL----------------------YDVIHTENK-------LTLVFEFMDND-LKKYMDSR 96 YD +++N L + EF D L+++++ R Sbjct: 69 HYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKR 128 Query: 97 TVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLAR 156 + L L L + Q+ +G+ + H K++HRDLKP N+ + Q+K+GDFGL Sbjct: 129 RGEKLDKVLALELFE----QITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT 184 Query: 157 AFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMI-TGKPLFPGTNDE 215 + S+ TL Y +P+ + S+ Y +D+++ G ILAE++ F + Sbjct: 185 SLKNDGKRTRSK-GTLRYMSPEQI-SSQDYGKEVDLYALGLILAELLHVCDTAFETSKFF 242 Query: 216 EQLK--LIFDIMGTPNESLWPS-VTKLPKYNPNIQQ 248 L+ +I DI ++L ++K P+ PN + Sbjct: 243 TDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSE 278 >5FM2-A nrPDB Length = 355 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 68/241 (28%), Positives = 113/241 (46%), Gaps = 38/241 (15%) Query: 13 LGNGTYATVYKGLN---KTTGVYVALKEVKLDSEEGTPSTA---IREISLMKELKHENIV 66 LG G + V K K Y + VK+ E +PS + E +++K++ H +++ Sbjct: 72 LGEGEFGKVVKATAFHLKGRAGYTTVA-VKMLKENASPSELRDLLSEFNVLKQVNHPHVI 130 Query: 67 RLYDVIHTENKLTLVFEFMD-NDLKKYM-DSRTVG---------------NTP--RGLEL 107 +LY + L L+ E+ L+ ++ +SR VG + P R L + Sbjct: 131 KLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTM 190 Query: 108 NLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSS 167 + F WQ+ QG+ + E K++HRDL +N+L+ + ++K+ DFGL+R V S Sbjct: 191 GDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRD----VYEEDS 246 Query: 168 EVVTLWYRAPDVLMGSRT-----YSTSIDIWSCGCILAEMIT--GKPLFPGTNDEEQLKL 220 V R P M + Y+T D+WS G +L E++T G P +PG E L Sbjct: 247 YVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP-YPGIPPERLFNL 305 Query: 221 I 221 + Sbjct: 306 L 306 >3GQL-A nrPDB Length = 326 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 35/237 (14%) Query: 13 LGNGTYATVY----KGLNKTTG---VYVALKEVKLDSEEGTPSTAIREISLMKEL-KHEN 64 LG G + V GL+K VA+K +K D+ E S I E+ +MK + KH+N Sbjct: 36 LGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 95 Query: 65 IVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLEL---------------N 108 I+ L + L ++ E+ +L++Y+ +R P GLE + Sbjct: 96 IINLLGACTQDGPLYVIVEYASKGNLREYLQARR----PPGLEYCYNPSHNPEEQLSSKD 151 Query: 109 LVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARA---FGIPVNTF 165 LV +Q+ +G+ + K +HRDL +N+L+ + +K+ DFGLAR T Sbjct: 152 LVS-CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTT 210 Query: 166 SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 + + W AP+ L R Y+ D+WS G +L E+ T G +PG EE KL+ Sbjct: 211 NGRLPVKWM-APEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL 265 >2A1A-B nrPDB Length = 284 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 73/264 (27%), Positives = 129/264 (48%), Gaps = 34/264 (12%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 FK++E +G+G + V+K ++ G +K VK ++E+ A RE+ + +L H NIV Sbjct: 13 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEK-----AEREVKALAKLDHVNIV 67 Query: 67 RL--------YDVIHTENK---------LTLVFEFMDND-LKKYMDSRTVGNTPRGLELN 108 YD T +K L + EF D L+++++ R + L L Sbjct: 68 HYNGCWDGFDYDP-ETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALE 126 Query: 109 LVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE 168 L + Q+ +G+ + H K+++RDLKP N+ + Q+K+GDFGL + S+ Sbjct: 127 LFE----QITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSK 182 Query: 169 VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMI-TGKPLFPGTNDEEQLK--LIFDIM 225 TL Y +P+ + S+ Y +D+++ G ILAE++ F + L+ +I DI Sbjct: 183 -GTLRYMSPEQI-SSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIF 240 Query: 226 GTPNESLWPS-VTKLPKYNPNIQQ 248 ++L ++K P+ PN + Sbjct: 241 DKKEKTLLQKLLSKKPEDRPNTSE 264 >6FER-A nrPDB Length = 309 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 58/224 (25%), Positives = 105/224 (46%), Gaps = 38/224 (16%) Query: 11 EKLGNGTYATVY----KGLNK------------TTGVYVALKEVKLDSEEGTPSTAIREI 54 EKLG G + V+ +G+ K V VA+K ++ D+ + + ++EI Sbjct: 15 EKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEI 74 Query: 55 SLMKELKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTP----RGLELNL 109 +M LK NI+ L V T++ L ++ E+M+N DL +++ N+ R + Sbjct: 75 KIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTN 134 Query: 110 VKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV 169 +K+ Q+ G+ + +HRDL +N L+ K +K+ DFG++R N +S + Sbjct: 135 LKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSR------NLYSGDY 188 Query: 170 VTL---------WYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT 204 + W +L+G ++T+ D+W+ G L E T Sbjct: 189 YRIQGRAVLPIRWMSWESILLGK--FTTASDVWAFGVTLWETFT 230 >3TT0-A nrPDB Length = 382 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 71/237 (29%), Positives = 112/237 (47%), Gaps = 35/237 (14%) Query: 13 LGNGTYATVY----KGLNKTTG---VYVALKEVKLDSEEGTPSTAIREISLMKEL-KHEN 64 LG G + V GL+K VA+K +K D+ E S I E+ +MK + KH+N Sbjct: 77 LGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 136 Query: 65 IVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLEL---------------N 108 I+ L + L ++ E+ +L++Y+ +R P GLE + Sbjct: 137 IINLLGACTQDGPLYVIVEYASKGNLREYLQARR----PPGLEYSYNPSHNPEEQLSSKD 192 Query: 109 LVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARA---FGIPVNTF 165 LV +Q+ +G+ + K +HRDL +N+L+ + +K+ DFGLAR T Sbjct: 193 LVS-CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTT 251 Query: 166 SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 + + W AP+ L R Y+ D+WS G +L E+ T G +PG EE KL+ Sbjct: 252 NGRLPVKWM-APEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL 306 >4JG6-A nrPDB Length = 355 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 76/299 (25%), Positives = 127/299 (42%), Gaps = 51/299 (17%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E +G G+Y+ + ++K T + A+K + D + P+ I EI L++ +H NI+ L D Sbjct: 41 EDIGVGSYSVCKRCIHKATNMEFAVKII--DKSKRDPTEEI-EI-LLRYGQHPNIITLKD 96 Query: 71 VIHTENKLTLVFEFMDND--LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 V + +V E M L K + + L + + + + + H Sbjct: 97 VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVL-------FTITKTVEYLHAQG 149 Query: 129 ILHRDLKPQNLL-INKRG---QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 ++HRDLKP N+L +++ G +++ DFG A+ + T + AP+VL + Sbjct: 150 VVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLE-RQ 208 Query: 185 TYSTSIDIWSCGCILAEMITG-KPLFPGTND--EEQLKLIFDIMGTPNESLWPSVTKLPK 241 Y + DIWS G +L M+TG P G +D EE L I + + W SV+ K Sbjct: 209 GYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAK 268 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 D + +L ++P RL+A L HPW + Sbjct: 269 ------------------------------DLVSKMLHVDPHQRLTAALVLRHPWIVHW 297 >2OU7-A nrPDB Length = 335 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 48/158 (30%), Positives = 79/158 (50%), Gaps = 8/158 (5%) Query: 53 EISLMKELKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVK 111 EIS+ + L H+++V + + + +V E L + R P + Sbjct: 91 EISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEA------R 144 Query: 112 YFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVT 171 Y+ Q++ G + H N+++HRDLK NL +N+ ++K+GDFGLA T Sbjct: 145 YYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGT 204 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLF 209 Y AP+VL + +S +D+WS GCI+ ++ GKP F Sbjct: 205 PNYIAPEVL-SKKGHSFEVDVWSIGCIMYTLLVGKPPF 241 >5HVK-A nrPDB Length = 315 Score = 80.5 bits (197), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 55/216 (25%), Positives = 103/216 (47%), Gaps = 38/216 (17%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKE-VKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 E LG G + K ++ TG + +KE ++ D E T T ++E+ +M+ L+H N+++ Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEE--TQRTFLKEVKVMRCLEHPNVLKFI 77 Query: 70 DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ--------LLQGL 121 V++ + +L + E++ G T RG+ ++ + W + G+ Sbjct: 78 GVLYKDKRLNFITEYIK------------GGTLRGIIKSMDSQYPWSQRVSFAKDIASGM 125 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLA-------------RAFGIPVNTFSSE 168 A+ H I+HR+L N L+ + + + DFGLA R+ P Sbjct: 126 AYLHSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYT 185 Query: 169 VV-TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMI 203 VV ++ AP+++ G R+Y +D++S G +L E+I Sbjct: 186 VVGNPYWMAPEMING-RSYDEKVDVFSFGIVLCEII 220 >4J52-A nrPDB Length = 293 Score = 80.5 bits (197), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 48/158 (30%), Positives = 79/158 (50%), Gaps = 8/158 (5%) Query: 53 EISLMKELKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVK 111 EIS+ + L H+++V + + + +V E L + R P + Sbjct: 64 EISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEA------R 117 Query: 112 YFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVT 171 Y+ Q++ G + H N+++HRDLK NL +N+ ++K+GDFGLA T Sbjct: 118 YYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGT 177 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLF 209 Y AP+VL + +S +D+WS GCI+ ++ GKP F Sbjct: 178 PNYIAPEVL-SKKGHSFEVDVWSIGCIMYTLLVGKPPF 214 >1FOT-A nrPDB Length = 318 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 57/218 (26%), Positives = 109/218 (50%), Gaps = 21/218 (9%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKE------VKLDSEEGTPSTAIREISL 56 S F+ L LG G++ V+ ++ G Y A+K V+L E T + + Sbjct: 4 SLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERL----M 59 Query: 57 MKELKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQW 115 + + H I+R++ ++ ++ ++++ +L + P + K++ Sbjct: 60 LSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNP------VAKFYAA 113 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 ++ L + H I++RDLKP+N+L++K G +K+ DFG A+ +P T++ T Y Sbjct: 114 EVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKY--VPDVTYTL-CGTPDYI 170 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTN 213 AP+V+ ++ Y+ SID WS G ++ EM+ G F +N Sbjct: 171 APEVV-STKPYNKSIDWWSFGILIYEMLAGYTPFYDSN 207 >2ZMD-A nrPDB Length = 390 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 82/305 (26%), Positives = 136/305 (44%), Gaps = 58/305 (19%) Query: 10 LEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLMKELKH--ENIV 66 L+++G+G + V++ LN+ +Y A+K V L+ + + R EI+ + +L+ + I+ Sbjct: 61 LKQIGSGGSSKVFQVLNEKKQIY-AIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKII 119 Query: 67 RLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 RLYD T+ + +V E + DL ++ + + ++ K + +L+ + H+ Sbjct: 120 RLYDYEITDQYIYMVMECGNIDLNSWLKKK------KSIDPWERKSYWKNMLEAVHTIHQ 173 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVTLWYRAPDVL--MG 182 + I+H DLKP N LI G LKL DFG+A + S+V + Y P+ + M Sbjct: 174 HGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMS 232 Query: 183 SR--------TYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESL- 232 S S D+WS GCIL M GK P N +L I D PN + Sbjct: 233 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIID----PNHEIE 288 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 +P + P +DL+ D L L+ +P R+S + L Sbjct: 289 FPDI-------------PEKDLQ----------------DVLKCCLKRDPKQRISIPELL 319 Query: 293 HHPWF 297 HP+ Sbjct: 320 AHPYV 324 >6CCF-A nrPDB Length = 290 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 79/321 (24%), Positives = 135/321 (42%), Gaps = 67/321 (20%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKL------------------DSEEGT 46 +Q+K ++G G Y V N++ + A+K + + +G Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 47 PSTAI-------REISLMKELKHENIVRLYDVIH--TENKLTLVFEFMDNDLKKYMDSRT 97 P+ + +EI+++K+L H N+V+L +V+ E+ L LVF+ L+K Sbjct: 65 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL----LRKGPVMEV 120 Query: 98 VGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARA 157 + P E + + ++ GL + H KI+HRD+KP NLL+ G +K+ DFG++ Sbjct: 121 PCDKPFSEEQ--ARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQ 178 Query: 158 FGIPVNTFSSEVVTLWYRAPDVLMGS-RTYS-TSIDIWSCGCILAEMITGKPLFPGTNDE 215 F SS T + AP+ + S +++S ++D+W+ G L + GK F D+ Sbjct: 179 FEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF---IDD 235 Query: 216 EQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLH 275 L L I P V+ P E + L D + Sbjct: 236 FILALHRKIKNEP----------------------------VVFPEEPE-ISEELKDLIL 266 Query: 276 GLLQLNPDMRLSAKQALHHPW 296 +L NP+ R+ HPW Sbjct: 267 KMLDKNPETRIGVPDIKLHPW 287 >3QGY-A nrPDB Length = 286 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 66/229 (28%), Positives = 121/229 (52%), Gaps = 30/229 (13%) Query: 5 SQFKQLEKLGNGTYATVYKG--LNKTTGVYVALKEVKLDSEEGTPSTA--IREISLMKEL 60 S+ ++++G+G + V+ G LNK VA+K +K EG+ S I E +M +L Sbjct: 27 SELTFVQEIGSGQFGLVHLGYWLNKDK---VAIKTIK----EGSMSEDDFIEEAEVMMKL 79 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRT---VGNTPRGLELNLVKYFQWQ 116 H +V+LY V + + LVFEFM++ L Y+ ++ T G+ L++ Sbjct: 80 SHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVC------ 133 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW--- 173 +G+A+ E ++HRDL +N L+ + +K+ DFG+ R + + ++S T + Sbjct: 134 --EGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRF--VLDDQYTSSTGTKFPVK 189 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 + +P+V SR YS+ D+WS G ++ E+ + GK + ++ E ++ I Sbjct: 190 WASPEVFSFSR-YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDI 237 >2HK5-A nrPDB Length = 270 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/218 (29%), Positives = 116/218 (53%), Gaps = 20/218 (9%) Query: 11 EKLGNGTYATVYKG-LNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 +KLG G + V+ NK T V A+K +K S + + E ++MK L+H+ +V+L+ Sbjct: 21 KKLGAGQFGEVWMATYNKHTKV--AVKTMKPGS--MSVEAFLAEANVMKTLQHDKLVKLH 76 Query: 70 DVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 V+ T+ + ++ EFM L ++ S P L + F Q+ +G+AF + Sbjct: 77 AVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQP----LPKLIDFSAQIAEGMAFIEQRN 131 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE---VVTLWYRAPDVL-MGSR 184 +HRDL+ N+L++ K+ DFGLAR I N +++ + + AP+ + GS Sbjct: 132 YIHRDLRAANILVSASLVCKIADFGLARV--IEDNEYTAREGAKFPIKWTAPEAINFGSF 189 Query: 185 TYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 T + D+WS G +L E++T G+ +PG ++ E ++ + Sbjct: 190 TIKS--DVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL 225 >5L6P-A nrPDB Length = 298 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 107/208 (51%), Gaps = 13/208 (6%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTG---VYVALKEVKLDSEEGTPSTAIREISLMKELK 61 S K E +G G + V +G K G V+VA+K +K+ E + E S+M + Sbjct: 19 SCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFD 78 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H NI+RL V+ + ++ EFM+N +DS N + + LV + + G+ Sbjct: 79 HPNIIRLEGVVTKSRPVMILTEFMEN---CALDSFLRLNDGQFTVIQLVGMLR-GIAAGM 134 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVN-TFSSEV---VTLWYRA 176 + E +HRDL +N+L+N K+ DFGL+R P + T++S + + + + A Sbjct: 135 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTA 194 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMIT 204 P+ + R ++++ D+WS G ++ E+++ Sbjct: 195 PEAI-AYRKFTSASDVWSYGIVMWEVMS 221 >3C1X-A nrPDB Length = 373 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 106/214 (49%), Gaps = 18/214 (8%) Query: 11 EKLGNGTYATVYKGL---NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVR 67 E +G G + VY G N ++ A+K + ++ G S + E +MK+ H N++ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLS 154 Query: 68 LYDV-IHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 L + + +E +V +M + DL+ ++ + T T + L F Q+ +G+ F Sbjct: 155 LLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDL-----IGFGLQVAKGMKFLA 209 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLAR-----AFGIPVNTFSSEVVTLWYRAPDVL 180 K +HRDL +N +++++ +K+ DFGLAR F N +++ W Sbjct: 210 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALES-- 267 Query: 181 MGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTN 213 + ++ ++T D+WS G +L E++T G P +P N Sbjct: 268 LQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVN 301 >3DLS-A nrPDB Length = 335 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 70/307 (22%), Positives = 128/307 (41%), Gaps = 60/307 (19%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-------EEGTPSTAIREISL 56 S ++ + LG+G + V+ ++K V +K +K + E+ EI++ Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI 82 Query: 57 MKELKHENIVRLYDVIHTENKLTLVFEFMDN--DLKKYMDSRTVGNTPRGLELNLVKYFQ 114 + ++H NI+++ D+ + LV E + DL ++D PR L+ L Y Sbjct: 83 LSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRH-----PR-LDEPLASYIF 136 Query: 115 WQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 QL+ + + I+HRD+K +N++I + +KL DFG A A+ F + T+ Y Sbjct: 137 RQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSA-AYLERGKLFYTFCGTIEY 195 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 AP+VLMG+ +++WS G L Sbjct: 196 CAPEVLMGNPYRGPELEMWSLGVTL----------------------------------- 220 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEP--LDGNLMDFLHGLLQLNPDMRLSAKQAL 292 Y ++ P +L + ++ P + LM + GLLQ P+ R + ++ + Sbjct: 221 -------YTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLV 273 Query: 293 HHPWFAE 299 PW + Sbjct: 274 TDPWVTQ 280 >4UYA-A nrPDB Length = 340 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 66/218 (30%), Positives = 106/218 (48%), Gaps = 27/218 (12%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA---IREISLMKELKHENIVR 67 E +G G + VY+ + G VA+K + D E+ + A RE L L+H NI+ Sbjct: 32 ELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIE 89 Query: 68 LYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 L V + L LV EF L + + R + P + +N + Q+ +G+ + HE Sbjct: 90 LRGVCLQQPHLCLVLEFARGGALNRALAGRRI---PPHVLVN----WAVQIARGMLYLHE 142 Query: 127 NK---ILHRDLKPQNLLINKRGQ--------LKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 ILHRDLK N+L+ ++ + LK+ DFGLAR + ++ + Sbjct: 143 EAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYA--WM 200 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTN 213 AP+V+ S +S DIWS G +L E++TG+ + G + Sbjct: 201 APEVIKSS-LFSKGSDIWSYGVLLWELLTGEVPYRGID 237 >4YHJ-A nrPDB Length = 584 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 105/211 (49%), Gaps = 11/211 (5%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGT--PSTAIREISLMKEL 60 + + F+ LG G + V + TG A K+++ + + A+ E +++++ Sbjct: 183 TKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV 242 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 + +V L T++ L LV M+ DLK ++ +GN G + ++ +L Sbjct: 243 QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHI--YNLGNP--GFDEQRAVFYAAELCC 298 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT-FSSEVVTLWYRAPD 178 GL +I++RDLKP+N+L++ RG +++ D GLA IP V T+ Y AP+ Sbjct: 299 GLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE--IPEGQRVRGRVGTVGYMAPE 356 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLF 209 V+ + Y+ S D W GC++ EMI G F Sbjct: 357 VVNNEK-YTFSPDWWGLGCLIYEMIQGHSPF 386 >4UY9-A nrPDB Length = 323 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 68/218 (31%), Positives = 105/218 (48%), Gaps = 27/218 (12%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST---AIREISLMKELKHENIVR 67 E +G G + VY+ G VA+K + D +E T +E L LKH NI+ Sbjct: 15 EIIGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIA 72 Query: 68 LYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 L V E L LV EF L + + + + P + +N + Q+ +G+ + H+ Sbjct: 73 LRGVCLKEPNLCLVMEFARGGPLNRVLSGKRI---PPDILVN----WAVQIARGMNYLHD 125 Query: 127 NKI---LHRDLKPQNLLINKRGQ--------LKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 I +HRDLK N+LI ++ + LK+ DFGLAR + T S T + Sbjct: 126 EAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH--RTTKMSAAGTYAWM 183 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTN 213 AP+V+ S +S D+WS G +L E++TG+ F G + Sbjct: 184 APEVIRAS-MFSKGSDVWSYGVLLWELLTGEVPFRGID 220 >5LOH-A nrPDB Length = 341 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 79/306 (25%), Positives = 129/306 (42%), Gaps = 49/306 (16%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKEL 60 S +F ++ + G + VY L + G A+K VK + E + Sbjct: 34 SIEEFSIVKPISRGAFGKVY--LGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALS 91 Query: 61 KHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 K IV LY + + N + LV E++ D+K + + E VKY ++ Sbjct: 92 KSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFD-----EEMAVKYIS-EVAL 145 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF------GIPVNTFSSEVVTLW 173 L + H + I+HRDLKP N+LI+ G +KL DFGL++ + + T + T Sbjct: 146 ALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPD 205 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 Y AP++L+G R + ++D W+ G L E +TG P F NDE ++ +I+ Sbjct: 206 YLAPELLLG-RAHGPAVDWWALGVCLFEFLTGIPPF---NDETPQQVFQNILK------- 254 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 R + P +E L N + LL ++ R K+ Sbjct: 255 ---------------------RDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKR 293 Query: 294 HPWFAE 299 HP F++ Sbjct: 294 HPLFSD 299 >1PHK-A nrPDB Length = 298 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 74/308 (24%), Positives = 126/308 (40%), Gaps = 58/308 (18%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKL------DSEEGTP--STAIREISLMKELK- 61 E LG G + V + ++K T A+K + + +EE ++E+ +++++ Sbjct: 23 EILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILRKVSG 82 Query: 62 HENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H NI++L D T LVF+ M +L Y+ + L + LL+ Sbjct: 83 HPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVT------LSEKETRKIMRALLEV 136 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 + H+ I+HRDLKP+N+L++ +KL DFG + P T Y AP+++ Sbjct: 137 ICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLD-PGEKLREVCGTPSYLAPEII 195 Query: 181 MGSRT-----YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFD---IMGTPNESL 232 S Y +D+WS G I+ ++ G P F L++I G+P Sbjct: 196 ECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPE--- 252 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 W + K D + L + P R +A++AL Sbjct: 253 WDDYSDTVK------------------------------DLVSRFLVVQPQKRYTAEEAL 282 Query: 293 HHPWFAEY 300 HP+F +Y Sbjct: 283 AHPFFQQY 290 >1AD5-A nrPDB Length = 438 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 110/215 (51%), Gaps = 24/215 (11%) Query: 11 EKLGNGTYATVYKG-LNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 +KLG G + V+ NK T V A+K +K S + + E ++MK L+H+ +V+L+ Sbjct: 188 KKLGAGQFGEVWMATYNKHTKV--AVKTMKPGSM--SVEAFLAEANVMKTLQHDKLVKLH 243 Query: 70 DVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 V+ T+ + ++ EFM L ++ S P L + F Q+ +G+AF + Sbjct: 244 AVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQP----LPKLIDFSAQIAEGMAFIEQRN 298 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFG-IPVNTFSSEVVTLWYRAPDVLMGSRTYS 187 +HRDL+ N+L++ K+ DFGLAR P+ + E + GS T Sbjct: 299 YIHRDLRAANILVSASLVCKIADFGLARVGAKFPIKWTAPEAINF---------GSFTIK 349 Query: 188 TSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 + D+WS G +L E++T G+ +PG ++ E ++ + Sbjct: 350 S--DVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL 382 >4XCU-A nrPDB Length = 300 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 60/223 (26%), Positives = 109/223 (48%), Gaps = 16/223 (7%) Query: 13 LGNGTYATVYK----GLNKT---TGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHEN 64 LG G + V + G++ VA+K +K ++ + + + E+ +MK + +H+N Sbjct: 25 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 84 Query: 65 IVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRG-LELNLVKYFQWQLLQGLA 122 I+ L V E L ++ E +L++++ +R + G L ++ +Q+ +G+ Sbjct: 85 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQVARGMQ 144 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARA---FGIPVNTFSSEVVTLWYRAPDV 179 + K +HRDL +N+L+ + +K+ DFGLAR T + + W AP+ Sbjct: 145 YLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWM-APEA 203 Query: 180 LMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 L R Y+ D+WS G +L E+ T G +PG EE L+ Sbjct: 204 LF-DRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL 245 >3UIM-A nrPDB Length = 326 Score = 78.2 bits (191), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 107/216 (49%), Gaps = 17/216 (7%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 +S F LG G + VYKG G VA+K +K + +G E+ ++ H Sbjct: 28 ASDNFSNKNILGRGGFGKVYKG-RLADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVH 86 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND-----LKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 N++RL T + LV+ +M N L++ +S+ + P+ + L Sbjct: 87 RNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSA----- 141 Query: 118 LQGLAFCHEN---KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-TLW 173 +GLA+ H++ KI+HRD+K N+L+++ + +GDFGLA+ ++ V T+ Sbjct: 142 -RGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIG 200 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLF 209 + AP+ L ++ S D++ G +L E+ITG+ F Sbjct: 201 HIAPEYLSTGKS-SEKTDVFGYGVMLLELITGQRAF 235 >6BDL-A nrPDB Length = 347 Score = 78.2 bits (191), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 60/224 (26%), Positives = 108/224 (48%), Gaps = 18/224 (8%) Query: 5 SQFKQLEKLGNGTYATV-----YKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLMK 58 S F ++ LG G + V +KT + + K +D+ + IR E +M+ Sbjct: 34 SDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQ---QEHIRSEKQIMQ 90 Query: 59 ELKHENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 + IVRLY L ++ E + +L + R E + +++ + Sbjct: 91 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRG------SFEDSTTRFYTACV 144 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 ++ A+ H I++RDLKP+NL+++ RG KL DFG A+ G T++ T Y AP Sbjct: 145 VEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTF-CGTPEYVAP 203 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLI 221 ++++ ++ + S D WS G ++ E++TG P F G + + +I Sbjct: 204 EIIL-NKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNII 246 >5LPV-A nrPDB Length = 296 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 65/218 (29%), Positives = 112/218 (51%), Gaps = 23/218 (10%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 + +++ F +G+G + VYK + K G VA+K++ S +G + E+ + ++ Sbjct: 13 LQATNGFHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGD-REFMAEMETIGKI 70 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPR--GLELNLVKYFQWQL- 117 KH N+V L ++ LV+EFM KY V + P+ G++LN + + Sbjct: 71 KHRNLVPLLGYCKVGDERLLVYEFM-----KYGSLEDVLHDPKKAGVKLNWSTRRKIAIG 125 Query: 118 -LQGLAFCHEN---KILHRDLKPQNLLINKRGQLKLGDFGLARAFG-----IPVNTFSSE 168 +GLAF H N I+HRD+K N+L+++ + ++ DFG+AR + V+T + Sbjct: 126 SARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAG- 184 Query: 169 VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGK 206 T Y P+ R ST D++S G +L E++TGK Sbjct: 185 --TPGYVPPEYYQSFRC-STKGDVYSYGVVLLELLTGK 219 >5LPZ-A nrPDB Length = 332 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 65/218 (29%), Positives = 112/218 (51%), Gaps = 23/218 (10%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 + +++ F +G+G + VYK + K G VA+K++ S +G + E+ + ++ Sbjct: 13 LQATNGFHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGD-REFMAEMETIGKI 70 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPR--GLELNLVKYFQWQL- 117 KH N+V L ++ LV+EFM KY V + P+ G++LN + + Sbjct: 71 KHRNLVPLLGYCKVGDERLLVYEFM-----KYGSLEDVLHDPKKAGVKLNWSTRRKIAIG 125 Query: 118 -LQGLAFCHEN---KILHRDLKPQNLLINKRGQLKLGDFGLARAFG-----IPVNTFSSE 168 +GLAF H N I+HRD+K N+L+++ + ++ DFG+AR + V+T + Sbjct: 126 SARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAG- 184 Query: 169 VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGK 206 T Y P+ R ST D++S G +L E++TGK Sbjct: 185 --TPGYVPPEYYQSFRC-STKGDVYSYGVVLLELLTGK 219 >3VN9-A nrPDB Length = 340 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 74/298 (24%), Positives = 131/298 (43%), Gaps = 53/298 (17%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVK--LDSEEGTPSTAIREISLMKELKHENIVRLY 69 +LG G Y V K + +G +A+K ++ ++S+E +IS M+ + V Y Sbjct: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPFTVTFY 116 Query: 70 DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN-K 128 + E + + E MD L K+ + V + + + +++ +++ L H Sbjct: 117 GALFREGDVWICMELMDTSLDKFY--KQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW--YRAPDVL---MGS 183 ++HRD+KP N+LIN GQ+K+ DFG++ G V++ + + Y AP+ + + Sbjct: 175 VIHRDVKPSNVLINALGQVKMCDFGIS---GYLVDSVAKTIDAGCKPYMAPERINPELNQ 231 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 + YS DIWS G + E+ L+ +D GTP Sbjct: 232 KGYSVKSDIWSLGITMIELAI-------------LRFPYDSWGTP--------------- 263 Query: 244 PNIQQRPPRDLRQVL-QPHTKEPLD---GNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 QQ L+QV+ +P + P D +DF L+ N R + + + HP+F Sbjct: 264 --FQQ-----LKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 >3I81-A nrPDB Length = 315 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 60/231 (25%), Positives = 113/231 (48%), Gaps = 26/231 (11%) Query: 12 KLGNGTYATVYKGLNKTT-----GVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 +LG G++ VY+G+ K VA+K V + + E S+MKE ++V Sbjct: 25 ELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVV 84 Query: 67 RLYDVIHTENKLTLVFEFMD-NDLKKYMDSR--TVGNTPRGLELNLVKYFQW--QLLQGL 121 RL V+ ++ E M DLK Y+ S + N P +L K Q ++ G+ Sbjct: 85 RLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGM 144 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE--------VVTLW 173 A+ + NK +HRDL +N ++ + +K+GDFG+ R + + ++ ++ + Sbjct: 145 AYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTR------DIYETDYYRKGGKGLLPVR 198 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFD 223 + +P+ L ++T D+WS G +L E+ T + + G ++E+ L+ + + Sbjct: 199 WMSPESLKDG-VFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVME 248 >3V5Q-A nrPDB Length = 297 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 67/230 (29%), Positives = 113/230 (49%), Gaps = 34/230 (14%) Query: 12 KLGNGTYATVYKG----LNKTTG-VYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 +LG G + V+ L+ T + VA+K +K D RE L+ L+HE+IV Sbjct: 22 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALK-DPTLAARKDFQREAELLTNLQHEHIV 80 Query: 67 RLYDVIHTENKLTLVFEFMDN-DLKKYMDSRT------VGNTPRG----LELNLVKYFQW 115 + Y V + L +VFE+M + DL K++ + V PR L L+ + + Sbjct: 81 KFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS 140 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE------- 168 Q+ G+ + +HRDL +N L+ +K+GDFG++R + +S++ Sbjct: 141 QIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSR------DVYSTDYYRVGGH 194 Query: 169 -VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GK-PLFPGTNDE 215 ++ + + P+ +M R ++T D+WS G IL E+ T GK P F +N E Sbjct: 195 TMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTE 243 >3DTC-A nrPDB Length = 271 Score = 77.0 bits (188), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 67/218 (30%), Positives = 104/218 (47%), Gaps = 27/218 (12%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST---AIREISLMKELKHENIVR 67 E +G G + VY+ G VA+K + D +E T +E L LKH NI+ Sbjct: 13 EIIGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIA 70 Query: 68 LYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 L V E L LV EF L + + + + P + +N + Q+ +G+ + H+ Sbjct: 71 LRGVCLKEPNLCLVMEFARGGPLNRVLSGKRI---PPDILVN----WAVQIARGMNYLHD 123 Query: 127 NKI---LHRDLKPQNLLINKRGQ--------LKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 I +HRDLK N+LI ++ + LK+ DFGLAR + T S + Sbjct: 124 EAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH--RTTKMSAAGAYAWM 181 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTN 213 AP+V+ S +S D+WS G +L E++TG+ F G + Sbjct: 182 APEVIRAS-MFSKGSDVWSYGVLLWELLTGEVPFRGID 218 >6E4F-A nrPDB Length = 290 Score = 77.0 bits (188), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 68/216 (31%), Positives = 112/216 (51%), Gaps = 25/216 (11%) Query: 10 LEKLGNGTYATVYKGLNKTTGVY-VALKEVKLDSEEGTPSTA--IREISLMKELKHENIV 66 L++LG G + V G K G Y VA+K +K EG+ S I E +M L HE +V Sbjct: 36 LKELGTGQFGVVKYG--KWRGQYDVAIKMIK----EGSMSEDEFIEEAKVMMNLSHEKLV 89 Query: 67 RLYDVIHTENKLTLVFEFMDND--LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 +LY V + + ++ E+M N L + R T + LE+ + + + + Sbjct: 90 QLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCK------DVCEAMEYL 143 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLM 181 + LHRDL +N L+N +G +K+ DFGL+R + + ++S V + + + P+VLM Sbjct: 144 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRY--VLDDEYTSSVGSKFPVRWSPPEVLM 201 Query: 182 GSRTYSTSIDIWSCGCILAEMIT-GK-PLFPGTNDE 215 S+ +S+ DIW+ G ++ E+ + GK P TN E Sbjct: 202 YSK-FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSE 236 >3FME-A nrPDB Length = 290 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 74/298 (24%), Positives = 131/298 (43%), Gaps = 53/298 (17%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVK--LDSEEGTPSTAIREISLMKELKHENIVRLY 69 +LG G Y V K + +G +A+K ++ ++S+E +IS M+ + V Y Sbjct: 14 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPFTVTFY 72 Query: 70 DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN-K 128 + E + + E MD L K+ + V + + + +++ +++ L H Sbjct: 73 GALFREGDVWICMELMDTSLDKFY--KQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 130 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW--YRAPDVL---MGS 183 ++HRD+KP N+LIN GQ+K+ DFG++ G V+ + ++ Y AP+ + + Sbjct: 131 VIHRDVKPSNVLINALGQVKMCDFGIS---GYLVDDVAKDIDAGCKPYMAPERINPELNQ 187 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 + YS DIWS G + E+ L+ +D GTP Sbjct: 188 KGYSVKSDIWSLGITMIELAI-------------LRFPYDSWGTP--------------- 219 Query: 244 PNIQQRPPRDLRQVL-QPHTKEPLD---GNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 QQ L+QV+ +P + P D +DF L+ N R + + + HP+F Sbjct: 220 --FQQ-----LKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 270 >4XI2-A nrPDB Length = 446 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 67/216 (31%), Positives = 112/216 (51%), Gaps = 25/216 (11%) Query: 10 LEKLGNGTYATVYKGLNKTTGVY-VALKEVKLDSEEGTPSTA--IREISLMKELKHENIV 66 L++LG G + V G K G Y VA+K ++ EG+ S I E +M L HE +V Sbjct: 192 LKELGTGQFGVVKYG--KWRGQYDVAIKMIR----EGSMSEDEFIEEAKVMMNLSHEKLV 245 Query: 67 RLYDVIHTENKLTLVFEFMDND--LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 +LY V + + ++ E+M N L + R T + LE+ + + + + Sbjct: 246 QLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCK------DVCEAMEYL 299 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLM 181 + LHRDL +N L+N +G +K+ DFGL+R + + ++S V + + + P+VLM Sbjct: 300 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRY--VLDDEYTSSVGSKFPVRWSPPEVLM 357 Query: 182 GSRTYSTSIDIWSCGCILAEMIT-GK-PLFPGTNDE 215 S+ +S+ DIW+ G ++ E+ + GK P TN E Sbjct: 358 YSK-FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSE 392 >4E93-A nrPDB Length = 377 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 57/231 (24%), Positives = 104/231 (45%), Gaps = 10/231 (4%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E++G G + V+ G + VA+K + + ++E ++K+ H NIVRL Sbjct: 120 EQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIG 179 Query: 71 VIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 V + + +V E + D ++ RT G L + + G+ + Sbjct: 180 VCTQKQPIYIVMELVQGGDFLTFL--RTEGAR---LRVKTLLQMVGDAAAGMEYLESKCC 234 Query: 130 LHRDLKPQNLLINKRGQLKLGDFGLAR--AFGIPVNTFSSEVVTLWYRAPDVLMGSRTYS 187 +HRDL +N L+ ++ LK+ DFG++R A G+ + V + + AP+ L R YS Sbjct: 235 IHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGR-YS 293 Query: 188 TSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 + D+WS G +L E + G +P ++++ + + P L P Sbjct: 294 SESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAV 344 >5HLW-A nrPDB Length = 299 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 108/213 (50%), Gaps = 16/213 (7%) Query: 11 EKLGNGTYATVYKGL---NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVR 67 E +G G + VY G N ++ A+K + ++ G S + E +MK+ H N++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLS 85 Query: 68 LYDV-IHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 L + + +E +V +M + DL+ ++ + T T + L F Q+ +G+ + Sbjct: 86 LLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDL-----IGFGLQVAKGMKYLA 140 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFG----IPVNTFSSEVVTLWYRAPDVLM 181 K +HRDL +N +++++ +K+ DFGLAR V+ + + + + A + L Sbjct: 141 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQ 200 Query: 182 GSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTN 213 ++ ++T D+WS G +L E++T G P +P N Sbjct: 201 -TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVN 232 >4K33-A nrPDB Length = 325 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 65/236 (27%), Positives = 111/236 (47%), Gaps = 33/236 (13%) Query: 13 LGNGTYATVYK----GLNKTTG---VYVALKEVKLDSEEGTPSTAIREISLMKEL-KHEN 64 LG G + V G++K V VA+K +K D+ + S + E+ +MK + KH+N Sbjct: 44 LGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 103 Query: 65 IVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNL-------------- 109 I+ L L ++ E+ +L++++ +R P GL+ + Sbjct: 104 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARR----PPGLDYSFDTSKPPEEQLTFKD 159 Query: 110 VKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARA---FGIPVNTFS 166 + +Q+ +G+ + K +HRDL +N+L+ + +K+ DFGLAR T + Sbjct: 160 LVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKETTN 219 Query: 167 SEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 + W AP+ L R Y+ D+WS G +L E+ T G +PG EE KL+ Sbjct: 220 GRLPVKWM-APEALF-DRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL 273 >5UUU-A nrPDB Length = 547 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 95/203 (46%), Gaps = 14/203 (6%) Query: 13 LGNGTYATVYKGLNKTTGVYVALK-----EVKLDSEEGTPSTAIREISLMKELKHENIVR 67 +G G + VY TG A+K +K+ E +SL+ IV Sbjct: 206 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 265 Query: 68 LYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 + HT +KL+ + + M+ DL ++ V + ++++ +++ GL H Sbjct: 266 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEAD------MRFYAAEIILGLEHMHN 319 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 +++RDLKP N+L+++ G +++ D GLA F + V T Y AP+VL Y Sbjct: 320 RFVVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVGTHGYMAPEVLQKGVAY 377 Query: 187 STSIDIWSCGCILAEMITGKPLF 209 +S D +S GC+L +++ G F Sbjct: 378 DSSADWFSLGCMLFKLLRGHSPF 400 >2I0E-A nrPDB Length = 353 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 57/226 (25%), Positives = 106/226 (46%), Gaps = 17/226 (7%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD---SEEGTPSTAIREISLMKELK 61 + F L LG G++ V K T A+K +K D ++ T + + L K Sbjct: 20 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 79 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 + +L+ T ++L V E+++ DL ++ P + ++ ++ G Sbjct: 80 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV------FYAAEIAIG 133 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF---GIPVNTFSSEVVTLWYRAP 177 L F I++RDLK N++++ G +K+ DFG+ + G+ TF T Y AP Sbjct: 134 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAP 190 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFD 223 +++ + Y S+D W+ G +L EM+ G+ F G +++E + I + Sbjct: 191 EII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 235 >3SXS-A nrPDB Length = 268 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 76/259 (29%), Positives = 126/259 (48%), Gaps = 37/259 (14%) Query: 10 LEKLGNGTYATVYKGLNKTTGVY-VALKEVKLDSEEGTPSTA--IREISLMKELKHENIV 66 L++LG+G + V L K G Y VA+K +K EG+ S +E M +L H +V Sbjct: 13 LKELGSGQFGVV--KLGKWKGQYDVAVKMIK----EGSMSEDEFFQEAQTMMKLSHPKLV 66 Query: 67 RLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 + Y V E + +V E++ N L Y+ S +GLE + + + + +G+AF Sbjct: 67 KFYGVCSKEYPIYIVTEYISNGCLLNYLRSHG-----KGLEPSQLLEMCYDVCEGMAFLE 121 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLMG 182 ++ +HRDL +N L+++ +K+ DFG+ R + + + S V T + + AP+V Sbjct: 122 SHQFIHRDLAARNCLVDRDLCVKVSDFGMTRY--VLDDQYVSSVGTKFPVKWSAPEVFHY 179 Query: 183 SRTYSTSIDIWSCGCILAEMIT-GK-PLFPGTNDEEQLK-----------LIFDIMGTPN 229 + YS+ D+W+ G ++ E+ + GK P TN E LK L D + Sbjct: 180 FK-YSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIM 238 Query: 230 ESLWPSVTKLPKYNPNIQQ 248 S W +LP+ P QQ Sbjct: 239 YSCW---HELPEKRPTFQQ 254 >1U59-A nrPDB Length = 287 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 56/199 (28%), Positives = 98/199 (49%), Gaps = 13/199 (6%) Query: 12 KLGNGTYATVYKGLNKTTG--VYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 +LG G + +V +G+ + + VA+K +K +E+ +RE +M +L + IVRL Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 76 Query: 70 DVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 V E L LV E L K++ VG N+ + Q+ G+ + E Sbjct: 77 GVCQAE-ALMLVMEMAGGGPLHKFL----VGKREEIPVSNVAELLH-QVSMGMKYLEEKN 130 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLMGSRT 185 +HRDL +N+L+ R K+ DFGL++A G + +++ W + AP+ + R Sbjct: 131 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRK 189 Query: 186 YSTSIDIWSCGCILAEMIT 204 +S+ D+WS G + E ++ Sbjct: 190 FSSRSDVWSYGVTMWEALS 208 >3PFQ-A nrPDB Length = 674 Score = 75.5 bits (184), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 57/226 (25%), Positives = 106/226 (46%), Gaps = 17/226 (7%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD---SEEGTPSTAIREISLMKELK 61 + F L LG G++ V K T A+K +K D ++ T + + L K Sbjct: 341 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 400 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 + +L+ T ++L V E+++ DL ++ P + ++ ++ G Sbjct: 401 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAV------FYAAEIAIG 454 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF---GIPVNTFSSEVVTLWYRAP 177 L F I++RDLK N++++ G +K+ DFG+ + G+ TF T Y AP Sbjct: 455 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAP 511 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFD 223 +++ + Y S+D W+ G +L EM+ G+ F G +++E + I + Sbjct: 512 EII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 556 >3PVW-A nrPDB Length = 695 Score = 75.5 bits (184), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 95/203 (46%), Gaps = 14/203 (6%) Query: 13 LGNGTYATVYKGLNKTTGVYVALK-----EVKLDSEEGTPSTAIREISLMKELKHENIVR 67 +G G + VY TG A+K +K+ E +SL+ IV Sbjct: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 Query: 68 LYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 + HT +KL+ + + M+ DL ++ V + ++++ +++ GL H Sbjct: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEAD------MRFYAAEIILGLEHMHN 310 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 +++RDLKP N+L+++ G +++ D GLA F + V T Y AP+VL Y Sbjct: 311 RFVVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVGTHGYMAPEVLQKGVAY 368 Query: 187 STSIDIWSCGCILAEMITGKPLF 209 +S D +S GC+L +++ G F Sbjct: 369 DSSADWFSLGCMLFKLLRGHSPF 391 >4OTD-A nrPDB Length = 341 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 67/225 (29%), Positives = 110/225 (48%), Gaps = 20/225 (8%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVK-----LDSEEGTPSTAIREISLMKEL 60 FK L LG G + V + +G A+K +K E + R ++ + Sbjct: 13 DFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSA 72 Query: 61 KHENIVRLYDVIHTENKLTLVFEF-MDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H +V L+ T + V E+ DL ++ S V + PR + ++ ++ Sbjct: 73 GHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAI------FYSACVVL 125 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLAR---AFGIPVNTFSSEVVTLWYRA 176 GL F HE+KI++RDLK NLL++ G +K+ DFGL + +G +TF T + A Sbjct: 126 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCG---TPEFLA 182 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLI 221 P+VL + +Y+ ++D W G +L EM+ G+ FPG ++EE I Sbjct: 183 PEVLTDT-SYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSI 226 >3ALO-A nrPDB Length = 327 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 72/312 (23%), Positives = 135/312 (43%), Gaps = 45/312 (14%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISL-MKELK 61 ++ K L ++G G Y +V K ++K +G +A+K ++ +E + ++ + M+ Sbjct: 20 TAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSD 79 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKK---YMDSRTVGNTPRGLELNLVKYFQWQLL 118 IV+ Y + E + E M K Y+ S P ++ + Sbjct: 80 CPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPE----EILGKITLATV 135 Query: 119 QGLAFCHEN-KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSS--EVVTLWYR 175 + L EN KI+HRD+KP N+L+++ G +KL DFG++ G V++ + + Y Sbjct: 136 KALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGIS---GQLVDSIAKTRDAGCRPYM 192 Query: 176 APDVLMGSRT---YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESL 232 AP+ + S + Y D+WS G L E+ TG+ +P N S+ Sbjct: 193 APERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWN-----------------SV 235 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 + +T++ ++ PP+ L + + ++F++ L + R K+ L Sbjct: 236 FDQLTQV------VKGDPPQ-----LSNSEEREFSPSFINFVNLCLTKDESKRPKYKELL 284 Query: 293 HHPWFAEYYHHA 304 HP+ Y A Sbjct: 285 KHPFILMYEERA 296 >4Y93-A nrPDB Length = 446 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 21/214 (9%) Query: 10 LEKLGNGTYATVYKGLNKTTGVY-VALKEVKLDSEEGTPSTA--IREISLMKELKHENIV 66 L++LG G + V G K G Y VA+K +K EG+ S I E +M L HE +V Sbjct: 193 LKELGTGQFGVVKYG--KWRGQYDVAIKMIK----EGSMSEDEFIEEAKVMMNLSHEKLV 246 Query: 67 RLYDVIHTENKLTLVFEFMDND--LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 +LY V + + ++ E+M N L + R T + LE+ + + + + Sbjct: 247 QLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCK------DVCEAMEYL 300 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLAR-AFGIPVNTFSSEVVTLWYRAPDVLMGS 183 + LHRDL +N L+N +G +K+ DFG+ R + + + + +P+VLM S Sbjct: 301 ESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYS 360 Query: 184 RTYSTSIDIWSCGCILAEMIT-GK-PLFPGTNDE 215 + +S+ DIW+ G ++ E+ + GK P TN E Sbjct: 361 K-FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSE 393 >5N23-A nrPDB Length = 352 Score = 75.1 bits (183), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 57/212 (26%), Positives = 107/212 (50%), Gaps = 22/212 (10%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALK------EVKLDSEEGTPSTAIREISLMKE 59 QF+++ LG G++ V +K TG + A+K VKL E T + E + + Sbjct: 43 QFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHT----LNEKRIQQA 98 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVG--NTPRGLELNLVKYFQWQL 117 + +V+L + L +V E+ + + R +G + P +++ Q+ Sbjct: 99 VNFPFLVKLEFSFKDNSNLYMVLEYAPGG-EMFSHLRRIGRFSEPHA------RFYAAQI 151 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + + H +++RDLKP+NLLI+++G +K+ DFG A+ + T + T Y AP Sbjct: 152 VLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKR--VKGRTPWTLCGTPEYLAP 209 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLF 209 ++++ S+ Y+ ++D W+ G ++ EM G P F Sbjct: 210 EIIL-SKGYNKAVDWWALGVLIYEMAAGYPPF 240 >4XLV-A nrPDB Length = 328 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 62/240 (25%), Positives = 112/240 (46%), Gaps = 26/240 (10%) Query: 3 SSSQFKQLEKLGNGTYATVYKG-----LNKTTGVYVALKEVKLDSEEGTPSTAIREISLM 57 S + L +LG G++ VY+G + VA+K V + + E S+M Sbjct: 37 SREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVM 96 Query: 58 KELKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDS--RTVGNTPRGLELNLVKYFQ 114 K ++VRL V+ +V E M + DLK Y+ S N P L + Q Sbjct: 97 KGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQ 156 Query: 115 W--QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE---- 168 ++ G+A+ + K +HRDL +N ++ +K+GDFG+ R + + ++ Sbjct: 157 MAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTR------DIYETDYYRK 210 Query: 169 ----VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFD 223 ++ + + AP+ L ++TS D+WS G +L E+ + + + G ++E+ LK + D Sbjct: 211 GGKGLLPVRWMAPESLKDG-VFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMD 269 >4F9B-A nrPDB Length = 361 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 86/353 (24%), Positives = 152/353 (43%), Gaps = 71/353 (20%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 S+ FK +K+G GT+++VY T + V +E K+ + P++ I + EL+ Sbjct: 20 SNVFKIEDKIGEGTFSSVYLA---TAQLQVGPEE-KIALKHLIPTS--HPIRIAAELQCL 73 Query: 64 NIVRLYDVIHTENKLTLVFEFMDND----LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 + D N + + + F ND Y++ + + L V+ + L + Sbjct: 74 TVAGGQD-----NVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFK 128 Query: 120 GLAFCHENKILHRDLKPQNLLINKR-GQLKLGDFGLARAF---GIPVNTF---------- 165 L H+ I+HRD+KP N L N+R + L DFGLA+ I + F Sbjct: 129 ALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERC 188 Query: 166 ---------------SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGK-PLF 209 + T +RAP+VL +T+ID+WS G I +++G+ P + Sbjct: 189 SQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFY 248 Query: 210 PGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQ---------P 260 ++D L I I G+ E++ + T K ++ P +DLR++ + P Sbjct: 249 KASDDLTALAQIMTIRGS-RETIQAAKT-FGKSILCSKEVPAQDLRKLCERLRGMDSSTP 306 Query: 261 HTKEPLDGNLMDFLHGLLQL--------------NPDMRLSAKQALHHPWFAE 299 + G+ + L G ++ NP R++A++AL HP+F + Sbjct: 307 KLTSDIQGHATN-LEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKD 358 >1LUF-A nrPDB Length = 343 Score = 74.7 bits (182), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 63/259 (24%), Positives = 113/259 (43%), Gaps = 42/259 (16%) Query: 5 SQFKQLEKLGNGTYATVYKG-----LNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKE 59 + + + +G G + V++ L VA+K +K ++ + RE +LM E Sbjct: 47 NNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAE 106 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDS------------------RTVGN 100 + NIV+L V + L+FE+M DL +++ S R Sbjct: 107 FDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSP 166 Query: 101 TPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGI 160 P L Q+ G+A+ E K +HRDL +N L+ + +K+ DFGL+R Sbjct: 167 GPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSR---- 222 Query: 161 PVNTFSS--------EVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPG 211 N +S+ + + + + P+ + +R Y+T D+W+ G +L E+ + G + G Sbjct: 223 --NIYSADYYKADGNDAIPIRWMPPESIFYNR-YTTESDVWAYGVVLWEIFSYGLQPYYG 279 Query: 212 TNDEEQLKLIFD--IMGTP 228 EE + + D I+ P Sbjct: 280 MAHEEVIYYVRDGNILACP 298 >1BYG-A nrPDB Length = 278 Score = 74.7 bits (182), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 106/208 (50%), Gaps = 16/208 (7%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 + K L+ +G G + V L G VA+K +K D+ T + E S+M +L+H N+ Sbjct: 22 ELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKNDA---TAQAFLAEASVMTQLRHSNL 76 Query: 66 VRLYDVIHTE-NKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 V+L VI E L +V E+M L Y+ SR G + G + L F + + + + Sbjct: 77 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR--GRSVLGGDCLL--KFSLDVCEAMEY 132 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 N +HRDL +N+L+++ K+ DFGL + +T + + + + AP+ L Sbjct: 133 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE---ASSTQDTGKLPVKWTAPEALR-E 188 Query: 184 RTYSTSIDIWSCGCILAEMIT-GKPLFP 210 + +ST D+WS G +L E+ + G+ +P Sbjct: 189 KKFSTKSDVWSFGILLWEIYSFGRVPYP 216 >2OZO-A nrPDB Length = 613 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 55/199 (27%), Positives = 99/199 (49%), Gaps = 13/199 (6%) Query: 12 KLGNGTYATVYKGLNK--TTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 +LG G + +V +G+ + + VA+K +K +E+ +RE +M +L + IVRL Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 Query: 70 DVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 V E L LV E L K++ VG + ++ V Q+ G+ + E Sbjct: 403 GVCQAE-ALMLVMEMAGGGPLHKFL----VGKREE-IPVSNVAELLHQVSMGMKYLEEKN 456 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLMGSRT 185 +HR+L +N+L+ R K+ DFGL++A G + +++ W + AP+ + R Sbjct: 457 FVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRK 515 Query: 186 YSTSIDIWSCGCILAEMIT 204 +S+ D+WS G + E ++ Sbjct: 516 FSSRSDVWSYGVTMWEALS 534 >4WB7-A nrPDB Length = 405 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 106/211 (50%), Gaps = 19/211 (9%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALK------EVKLDSEEGTPSTAIREISLMK 58 QF++++ LG G++ V +K TG + A+K VKL E T + E +++ Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHT----LNEKRILQ 151 Query: 59 ELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 + +V+L + L +V E++ + + R +G +++ Q++ Sbjct: 152 AVNFPFLVKLEFSFKDNSNLYMVMEYVPGG-EMFSHLRRIGR----FSEPHARFYAAQIV 206 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 + H +++RDLKP+NLLI+++G +++ DFG A+ T T Y AP+ Sbjct: 207 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---TPEYLAPE 263 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLF 209 +++ S+ Y+ ++D W+ G ++ EM G P F Sbjct: 264 IIL-SKGYNKAVDWWALGVLIYEMAAGYPPF 293 >1K9A-A nrPDB Length = 450 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 106/208 (50%), Gaps = 16/208 (7%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 + K L+ +G G + V L G VA+K +K D+ T + E S+M +L+H N+ Sbjct: 194 ELKLLQTIGKGEFGDVM--LGDYRGNKVAVKCIKNDA---TAQAFLAEASVMTQLRHSNL 248 Query: 66 VRLYDVIHTE-NKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 V+L VI E L +V E+M L Y+ SR G + G + L F + + + + Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR--GRSVLGGDCLL--KFSLDVCEAMEY 304 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 N +HRDL +N+L+++ K+ DFGL + +T + + + + AP+ L Sbjct: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE---ASSTQDTGKLPVKWTAPEALR-E 360 Query: 184 RTYSTSIDIWSCGCILAEMIT-GKPLFP 210 + +ST D+WS G +L E+ + G+ +P Sbjct: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYP 388 >4EBW-A nrPDB Length = 304 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 63/251 (25%), Positives = 125/251 (49%), Gaps = 21/251 (8%) Query: 13 LGNGTYATVYKGLN---KTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 +G G + V++G+ + + VA+K K + + ++E M++ H +IV+L Sbjct: 46 IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI 105 Query: 70 DVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 VI TEN + ++ E +L+ ++ R L+L + + +QL LA+ + Sbjct: 106 GVI-TENPVWIIMELCTLGELRSFLQVRKYS-----LDLASLILYAYQLSTALAYLESKR 159 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE-VVTLWYRAPDVLMGSRTYS 187 +HRD+ +N+L++ +KLGDFGL+R +S+ + + + AP+ + R ++ Sbjct: 160 FVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESI-NFRRFT 218 Query: 188 TSIDIWSCG-CILAEMITGKPLFPGTNDEEQLKLIFD---IMGTPN--ESLWPSVTKLPK 241 ++ D+W G C+ ++ G F G + + + I + + PN +L+ +TK Sbjct: 219 SASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWA 278 Query: 242 YNPNIQQRPPR 252 Y+P+ R PR Sbjct: 279 YDPS---RRPR 286 >3C51-A nrPDB Length = 543 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 68/283 (24%), Positives = 115/283 (40%), Gaps = 34/283 (12%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPS--TAIREISLMKELKHEN 64 F LG G + V+ K TG A K++ + A+ E ++ ++ Sbjct: 187 FLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRF 246 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 IV L T+ L LV M+ +Y + P G + ++ Q++ GL Sbjct: 247 IVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNP-GFQEPRAIFYTAQIVSGLEHL 305 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 H+ I++RDLKP+N+L++ G +++ D GLA T + AP++L+G Sbjct: 306 HQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEE 365 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 Y S+D ++ G L EMI + F ++ + K + L +VT K++P Sbjct: 366 -YDFSVDYFALGVTLYEMIAARGPFRARGEKVENKEL------KQRVLEQAVTYPDKFSP 418 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 + DF LLQ +P+ RL Sbjct: 419 ASK------------------------DFCEALLQKDPEKRLG 437 >5O0Y-A nrPDB Length = 579 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 62/223 (27%), Positives = 102/223 (45%), Gaps = 30/223 (13%) Query: 18 YATVYKGLNKTTGVYVALKEVKL------DSEEGTPSTAIREISLMKELKHENIVRLYDV 71 ++ VYK + T YVA+K +L + +E A RE + KEL H IV+LYD Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 72 IHTE-NKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK- 128 + + V E+ + NDL Y+ + + + + Q++ L + +E K Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIM------QIVNALKYLNEIKP 410 Query: 129 -ILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIP-------VNTFSSEVVTLWYRAP 177 I+H DLKP N+L+ G++K+ DFGL++ + S T WY P Sbjct: 411 PIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPP 470 Query: 178 DVLMGSR---TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQ 217 + + + S +D+WS G I + + G+ F G N +Q Sbjct: 471 ECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQ 512 >2J0K-A nrPDB Length = 656 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 63/251 (25%), Positives = 125/251 (49%), Gaps = 21/251 (8%) Query: 13 LGNGTYATVYKGLN---KTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 +G G + V++G+ + + VA+K K + + ++E M++ H +IV+L Sbjct: 398 IGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI 457 Query: 70 DVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 VI TEN + ++ E +L+ ++ R L+L + + +QL LA+ + Sbjct: 458 GVI-TENPVWIIMELCTLGELRSFLQVRKFS-----LDLASLILYAYQLSTALAYLESKR 511 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE-VVTLWYRAPDVLMGSRTYS 187 +HRD+ +N+L++ +KLGDFGL+R +S+ + + + AP+ + R ++ Sbjct: 512 FVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESI-NFRRFT 570 Query: 188 TSIDIWSCG-CILAEMITGKPLFPGTNDEEQLKLIFD---IMGTPN--ESLWPSVTKLPK 241 ++ D+W G C+ ++ G F G + + + I + + PN +L+ +TK Sbjct: 571 SASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWA 630 Query: 242 YNPNIQQRPPR 252 Y+P+ R PR Sbjct: 631 YDPS---RRPR 638 >2VWV-A nrPDB Length = 302 Score = 73.6 bits (179), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 100/208 (48%), Gaps = 13/208 (6%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTG---VYVALKEVKLDSEEGTPSTAIREISLMKELK 61 S K E +G G + V +G K G VA+K +K E + E S+M + + Sbjct: 16 SYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFE 75 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H NI+RL V+ + ++ EFM+N +DS N + + LV + + G+ Sbjct: 76 HPNIIRLEGVVTNSMPVMILTEFMENGA---LDSFLRLNDGQFTVIQLVGMLR-GIASGM 131 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF----GIPVNTFS-SEVVTLWYRA 176 + E +HRDL +N+L+N K+ DFGL+R P T S + + + A Sbjct: 132 RYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTA 191 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMIT 204 P+ + R ++++ D WS G ++ E+++ Sbjct: 192 PEAI-AFRKFTSASDAWSYGIVMWEVMS 218 >1JPA-A nrPDB Length = 312 Score = 73.6 bits (179), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 56/221 (25%), Positives = 109/221 (49%), Gaps = 15/221 (6%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTG---VYVALKEVKLDSEEGTPSTAIREISLMKELK 61 S K + +G G + V G K G ++VA+K +K E + E S+M + Sbjct: 33 SCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFD 92 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H N++ L V+ + ++ EFM+N +DS N + + LV + + G+ Sbjct: 93 HPNVIHLEGVVTKSTPVMIITEFMEN---GSLDSFLRQNDGQFTVIQLVGMLR-GIAAGM 148 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN--TFSSEV---VTLWYRA 176 + + +HRDL +N+L+N K+ DFGL+R + T++S + + + + A Sbjct: 149 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 208 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMIT--GKPLFPGTNDE 215 P+ + R ++++ D+WS G ++ E+++ +P + TN + Sbjct: 209 PEAIQ-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQD 248 >5GNK-A nrPDB Length = 297 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 54/219 (24%), Positives = 102/219 (46%), Gaps = 38/219 (17%) Query: 5 SQFKQLEKLGNGTYATVYKGL----NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 ++FK+++ LG+G + TVYKGL + + VA+KE++ + + E +M + Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 78 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVK--------- 111 + ++ RL + T + + L+ + M P G L+ V+ Sbjct: 79 DNPHVCRLLGICLT-STVQLIMQLM----------------PFGCLLDYVREHKDNIGSQ 121 Query: 112 -YFQW--QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE 168 W Q+ +G+ + + +++HRDL +N+L+ +K+ DFGLA+ G + +E Sbjct: 122 YLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE 181 Query: 169 ---VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT 204 V W +L R Y+ D+WS G + E++T Sbjct: 182 GGKVPIKWMALESIL--HRIYTHQSDVWSYGVTVWELMT 218 >5TOS-A nrPDB Length = 395 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 110/218 (50%), Gaps = 18/218 (8%) Query: 3 SSSQFKQLEKLGNGTYATVYKG-LNKTT--------GVYVALKEVKLDSEEGTPSTAIRE 53 ++ F+ +G G + V+KG L+++T G+ +A+K++ + +G + E Sbjct: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTE 121 Query: 54 ISLMKELKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKY 112 I+ + +L H N+V+L + LV+EFM L+ ++ R P L L Sbjct: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP--LPWFLRVN 179 Query: 113 FQWQLLQGLAFCHEN--KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV 170 +GLAF H + K+++RD+K N+L++ KL DFGLAR + ++ S V Sbjct: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 Query: 171 --TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGK 206 T Y AP+ M S + D++S G +L E+++GK Sbjct: 240 MGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGK 276 >4HVI-A nrPDB Length = 314 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 97/209 (46%), Gaps = 17/209 (8%) Query: 6 QFKQLEKLGNGTYATV----YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 K + +LG G + +V Y L TG VA+K+++ S REI ++K L Sbjct: 11 HLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HSGPDQQRDFQREIQILKALH 69 Query: 62 HENIVRLYDVIHTENK--LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 + IV+ V + + L LV E++ + + R L+ + + + Q+ + Sbjct: 70 SDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR----LDASRLLLYSSQICK 125 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF----SSEVVTLWYR 175 G+ + + +HRDL +N+L+ +K+ DFGLA+ + + + + WY Sbjct: 126 GMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWY- 184 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMIT 204 AP+ L +S D+WS G +L E+ T Sbjct: 185 APESL-SDNIFSRQSDVWSFGVVLYELFT 212 >5X3F-B nrPDB Length = 393 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 105/213 (49%), Gaps = 25/213 (11%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE-N 64 QF +++ LG G++ V +K +G + A+K LD ++ + +K+++H N Sbjct: 85 QFDRIKTLGTGSFGRVMLVKHKESGNHYAMK--ILDKQK---------VVKLKQIEHTLN 133 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLV--------KYFQWQ 116 R+ ++ + L F F DN YM V L + +++ Q Sbjct: 134 EKRILQAVNFPFLVKLEFSFKDNS-NLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQ 192 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 ++ + H +++RDLKP+NLLI+++G +++ DFG A+ T T Y A Sbjct: 193 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---TPEYLA 249 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLF 209 P++++ S+ Y+ ++D W+ G ++ EM G P F Sbjct: 250 PEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPF 281 >5HI2-A nrPDB Length = 283 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 128/244 (52%), Gaps = 23/244 (9%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 +++G+G++ TVYKG K G VA+K + + + E+ ++++ +H NI+ L+ Sbjct: 26 QRIGSGSFGTVYKG--KWHGD-VAVKMLTPQQLQAFKN----EVGVLRKTRHVNIL-LFM 77 Query: 71 VIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 T+ +L +V ++ + + L ++ + + E+ + Q +G+ + H I Sbjct: 78 GYSTKPQLAIVTQWCEGSSLYHHLHA-----SETKFEMKKLIDIARQTARGMDYLHAKSI 132 Query: 130 LHRDLKPQNLLINKRGQLKLGDFGLA--RAFGIPVNTFSSEVVTLWYRAPDV--LMGSRT 185 +HRDLK N+ +++ +K+GDFGLA ++ + F ++ + AP+V + S Sbjct: 133 IHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNP 192 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 YS D+++ G +L E++TG+ + N+ +Q I +++G SL P ++K+ P Sbjct: 193 YSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ---IIEMVG--RGSLSPDLSKVRSNCPK 247 Query: 246 IQQR 249 +R Sbjct: 248 RMKR 251 >3LLT-A nrPDB Length = 360 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 85/344 (24%), Positives = 154/344 (44%), Gaps = 62/344 (18%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 M ++ F + K+G+GT+ V + Y A+K V+ + ++ T S I E ++K++ Sbjct: 31 MLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVR-NIKKYTRSAKI-EADILKKI 88 Query: 61 KHENI-----VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 ++++I V+ + + + L+FE + L + + N G + +K + Sbjct: 89 QNDDINNNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITR----NNYNGFHIEDIKLYCI 144 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLIN-------------------------KRGQLKLG 150 ++L+ L + + + H DLKP+N+L++ K +KL Sbjct: 145 EILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLI 204 Query: 151 DFGLARAFGIPVNTFSSE-----VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITG 205 DFG A TF S+ + T YRAP+V++ + + S D+WS GC+LAE+ TG Sbjct: 205 DFGCA--------TFKSDYHGSIINTRQYRAPEVIL-NLGWDVSSDMWSFGCVLAELYTG 255 Query: 206 KPLFPGTNDEEQLKLIFDIMG-TPNESLWPSV-TKLPKY--NPNIQQRPPRDLRQVLQ-P 260 LF E L ++ I+ P L+ + T KY ++ P + + Sbjct: 256 SLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIK 315 Query: 261 HTKEPL-------DGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 H K+ L DFL+ +LQ++P +R S + L H + Sbjct: 316 HVKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFL 359 >3OMV-A nrPDB Length = 307 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 70/251 (27%), Positives = 129/251 (51%), Gaps = 34/251 (13%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLMKELKHENIVRLYD 70 ++G+G++ TVYKG K G VA+K +K+ A R E++++++ +H NI+ L+ Sbjct: 43 RIGSGSFGTVYKG--KWHGD-VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL-LFM 98 Query: 71 VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL-------QGLAF 123 T++ L +V ++ + + + L + K+ +QL+ QG+ + Sbjct: 99 GYMTKDNLAIVTQWCEGS-----------SLYKHLHVQETKFQMFQLIDIARQTAQGMDY 147 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVT---LWYRAPDV- 179 H I+HRD+K N+ +++ +K+GDFGLA + E T LW AP+V Sbjct: 148 LHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWM-APEVI 206 Query: 180 -LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 + + +S D++S G +L E++TG+ + N+ +Q +IF ++G S P ++K Sbjct: 207 RMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQ--IIF-MVGRGYAS--PDLSK 261 Query: 239 LPKYNPNIQQR 249 L K P +R Sbjct: 262 LYKNCPKAMKR 272 >3PPZ-A nrPDB Length = 309 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 99/200 (49%), Gaps = 14/200 (7%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 EK+G G++ TV++ + V V + ++ D + +RE+++MK L+H NIV Sbjct: 43 EKIGAGSFGTVHRAEWHGSDVAVKIL-MEQDFHAERVNEFLREVAIMKRLRHPNIVLFMG 101 Query: 71 VIHTENKLTLVFEFMDND----LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 + L++V E++ L +R + R L + + + +G+ + H Sbjct: 102 AVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSM------AYDVAKGMNYLHN 155 Query: 127 NK--ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 I+HRDLK NLL++K+ +K+ DFGL+R + S T + AP+VL Sbjct: 156 RNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEP 215 Query: 185 TYSTSIDIWSCGCILAEMIT 204 + S D++S G IL E+ T Sbjct: 216 SNEKS-DVYSFGVILWELAT 234 >2HW6-A nrPDB Length = 307 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 75/308 (24%), Positives = 124/308 (40%), Gaps = 50/308 (16%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HENIVRLY 69 E LG G YA V ++ G A+K ++ + + S RE+ + + + ++NI+ L Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGH-SRSRVFREVETLYQCQGNKNILELI 77 Query: 70 DVIHTENKLTLVFEFMDN-------DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 + + + LVFE + +K+ + R R + L Sbjct: 78 EFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVR------------DVAAALD 125 Query: 123 FCHENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGI-----PVNT--FSSEVVTL 172 F H I HRDLKP+N+L K +K+ DF L + P+ T ++ + Sbjct: 126 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 185 Query: 173 WYRAPDVLM----GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTP 228 Y AP+V+ + Y D+WS G +L M++G P F G + ++ Sbjct: 186 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 245 Query: 229 NESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA 288 L+ S+ + KY + P +D + D + LL + RLSA Sbjct: 246 QNKLFESIQE-GKY-----EFPDKDWAHI---------SSEAKDLISKLLVRDAKQRLSA 290 Query: 289 KQALHHPW 296 Q L HPW Sbjct: 291 AQVLQHPW 298 >6CKI-A nrPDB Length = 316 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 84/307 (27%), Positives = 131/307 (42%), Gaps = 44/307 (14%) Query: 9 QLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEG-TPSTAIREISLMKELK-HENIV 66 Q + LG G +A V +N T A+K ++ + G S RE+ ++ + + H N++ Sbjct: 17 QEDVLGEGAHARVQTCINLITSQEYAVK--IIEKQPGHIRSRVFREVEMLYQCQGHRNVL 74 Query: 67 RLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 L + E++ LVFE M + ++ R N LE ++V + L F H Sbjct: 75 ELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNE---LEASVVVQ---DVASALDFLH 128 Query: 126 ENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVT---------LW 173 I HRDLKP+N+L N+ +K+ DFGL GI +N S + T Sbjct: 129 NKGIAHRDLKPENILCEHPNQVSPVKICDFGLGS--GIKLNGDCSPISTPELLTPCGSAE 186 Query: 174 YRAPDVLMG----SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPN 229 Y AP+V+ + Y D+WS G IL +++G P F G + + Sbjct: 187 YMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQ 246 Query: 230 ESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 L+ S+ + KY + P +D + D + LL + RLSA Sbjct: 247 NMLFESIQE-GKY-----EFPDKDWAHI---------SCAAKDLISKLLVRDAKQRLSAA 291 Query: 290 QALHHPW 296 Q L HPW Sbjct: 292 QVLQHPW 298 >4IDT-A nrPDB Length = 356 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 53/201 (26%), Positives = 95/201 (47%), Gaps = 20/201 (9%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 +LG G++ V++ +K TG A+K+V+L+ E+ L IV LY Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEV------FRAEELMACAGLTSPRIVPLYGA 134 Query: 72 IHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 + + + E ++ L + + + R L Y+ Q L+GL + H +IL Sbjct: 135 VREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRAL------YYLGQALEGLEYLHSRRIL 188 Query: 131 HRDLKPQNLLINKRG-QLKLGDFGLARAF---GIPVNTFSSEVV--TLWYRAPDVLMGSR 184 H D+K N+L++ G L DFG A G+ + + + + T + AP+V++G R Sbjct: 189 HGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG-R 247 Query: 185 TYSTSIDIWSCGCILAEMITG 205 + +D+WS C++ M+ G Sbjct: 248 SCDAKVDVWSSCCMMLHMLNG 268 >3LZB-A nrPDB Length = 327 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 54/219 (24%), Positives = 102/219 (46%), Gaps = 38/219 (17%) Query: 5 SQFKQLEKLGNGTYATVYKGL----NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 ++FK+++ LG+G + TVYKGL + + VA+KE++ + + E +M + Sbjct: 15 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 74 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVK--------- 111 + ++ RL + T + + L+ + M P G L+ V+ Sbjct: 75 DNPHVCRLLGICLT-STVQLITQLM----------------PFGCLLDYVREHKDNIGSQ 117 Query: 112 -YFQW--QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE 168 W Q+ +G+ + + +++HRDL +N+L+ +K+ DFGLA+ G + +E Sbjct: 118 YLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE 177 Query: 169 ---VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT 204 V W +L R Y+ D+WS G + E++T Sbjct: 178 GGKVPIKWMALESIL--HRIYTHQSDVWSYGVTVWELMT 214 >3DKO-A nrPDB Length = 318 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/212 (26%), Positives = 101/212 (47%), Gaps = 21/212 (9%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTG---VYVALKEVKLDSEEGTPSTAIREISLMKEL 60 +S K +G G + V G K G V VA+K +K+ E + E S+M + Sbjct: 42 ASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQF 101 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDND-----LKKYMDSRTVGNTPRGLELNLVKYFQW 115 H N+V L V+ + +V EFM+N L+K+ TV + LV + Sbjct: 102 DHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTV--------IQLVGMLR- 152 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGI---PVNTFSSEVVTL 172 + G+ + + +HRDL +N+L+N K+ DFGL+R V T + + + Sbjct: 153 GIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPV 212 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT 204 + AP+ + R ++++ D+WS G ++ E+++ Sbjct: 213 RWTAPEAIQ-YRKFTSASDVWSYGIVMWEVMS 243 >5VD3-A nrPDB Length = 311 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 63/217 (29%), Positives = 101/217 (46%), Gaps = 14/217 (6%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLM----KELKH 62 F++L +LG+G+Y V+K +K G A+K + S P R+++ + K +H Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVK--RSMSPFRGPKDRARKLAEVGSHEKVGQH 116 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 VRL L L E L+++ ++ + P E + Y + LL LA Sbjct: 117 PCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGA-SLP---EAQVWGYLRDTLL-ALA 171 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 H ++H D+KP N+ + RG+ KLGDFGL G + Y AP++L G Sbjct: 172 HLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGT-AGAGEVQEGDPRYMAPELLQG 230 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLK 219 S Y T+ D++S G + E+ L G +QL+ Sbjct: 231 S--YGTAADVFSLGLTILEVACNMELPHGGEGWQQLR 265 >4G3E-A nrPDB Length = 352 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 54/201 (26%), Positives = 98/201 (48%), Gaps = 20/201 (9%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 ++G G++ V++ +K TG A+K+V+L+ + E+ L IV LY Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRLEV------FRVEELVACAGLSSPRIVPLYGA 134 Query: 72 IHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 + + + E ++ L + + + +G P L Y+ Q L+GL + H +IL Sbjct: 135 VREGPWVNIFMELLEGGSLGQLI--KQMGCLPEDRAL----YYLGQALEGLEYLHTRRIL 188 Query: 131 HRDLKPQNLLINKRG-QLKLGDFGLARAF---GIPVNTFSSEVV--TLWYRAPDVLMGSR 184 H D+K N+L++ G + L DFG A G+ + + + + T + AP+V+MG + Sbjct: 189 HGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-K 247 Query: 185 TYSTSIDIWSCGCILAEMITG 205 +DIWS C++ M+ G Sbjct: 248 PCDAKVDIWSSCCMMLHMLNG 268 >3ZZW-A nrPDB Length = 289 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 67/271 (24%), Positives = 129/271 (47%), Gaps = 25/271 (9%) Query: 3 SSSQFKQLEKLGNGTYATVYKG--LNKTTG---VYVALKEVKLDSEEGTPSTAIR-EISL 56 S S + +E+LG + VYKG G VA+K +K D EG R E L Sbjct: 7 SLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLK-DKAEGPLREEFRHEAML 65 Query: 57 MKELKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRT----VGNT------PRGL 105 L+H N+V L V+ + L+++F + + DL +++ R+ VG+T L Sbjct: 66 RARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSAL 125 Query: 106 ELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIP--VN 163 E + Q+ G+ + + ++H+DL +N+L+ + +K+ D GL R Sbjct: 126 EPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYK 185 Query: 164 TFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIF 222 + ++ + + AP+ +M + +S DIWS G +L E+ + G + G ++++ +++I Sbjct: 186 LLGNSLLPIRWMAPEAIMYGK-FSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIR 244 Query: 223 D--IMGTPNES-LWPSVTKLPKYNPNIQQRP 250 + ++ P++ W + +N +RP Sbjct: 245 NRQVLPCPDDCPAWVYALMIECWNEFPSRRP 275 >2OGV-A nrPDB Length = 317 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 100/213 (46%), Gaps = 15/213 (7%) Query: 13 LGNGTYATVYK----GLNKTTGVY-VALKEVKLDSEEGTPSTAIREISLMKEL-KHENIV 66 LG G + V + GL K V VA+K +K + + E+ +M L +HENIV Sbjct: 46 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 105 Query: 67 RLYDVIHTENKLTLVFEF-----MDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 L + ++ E+ + N L++ ++ R LEL + +F Q+ QG+ Sbjct: 106 NLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGM 165 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVTLWYRAPDV 179 AF +HRD+ +N+L+ K+GDFGLAR N + + + + AP+ Sbjct: 166 AFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPES 225 Query: 180 LMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPG 211 + Y+ D+WS G +L E+ + G +PG Sbjct: 226 IFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPG 257 >5KMM-A nrPDB Length = 329 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 60/229 (26%), Positives = 113/229 (49%), Gaps = 33/229 (14%) Query: 12 KLGNGTYATVYKG-----LNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 +LG G + V+ L + + VA+K +K ++ E RE L+ L+H++IV Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQDFQREAELLTMLQHQHIV 100 Query: 67 RLYDVIHTENKLTLVFEFMDN-DLKKYM-----DSRTVGN----TPRGLELNLVKYFQWQ 116 R + V L +VFE+M + DL +++ D++ + P L L + Q Sbjct: 101 RFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQ 160 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE-------- 168 + G+ + +HRDL +N L+ + +K+GDFG++R + +S++ Sbjct: 161 VAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR------DIYSTDYYRVGGRT 214 Query: 169 VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GK-PLFPGTNDE 215 ++ + + P+ ++ R ++T D+WS G +L E+ T GK P + +N E Sbjct: 215 MLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTE 262 >5X5O-A nrPDB Length = 310 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 107/226 (47%), Gaps = 34/226 (15%) Query: 1 MSSSSQFKQL--------EKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAI 51 M S + F Q+ E G G++ +VY+ + VA+K++ K++ Sbjct: 3 MGSGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE---------- 52 Query: 52 REISLMKELKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLV 110 +E ++ L H NI++ Y VI +V E+ L Y+ N+ R E+++ Sbjct: 53 KEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYI------NSNRSEEMDMD 106 Query: 111 KYFQW--QLLQGLAFCHEN---KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF 165 W + +G+ + H K++HRDLK +N++I G LK+ DFG +R T Sbjct: 107 HIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHN--HTTH 164 Query: 166 SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG 211 S V T + AP+V+ S S + D +S G +L EM+T + F G Sbjct: 165 MSLVGTFPWMAPEVIQ-SLPVSETCDTYSYGVVLWEMLTREVPFKG 209 >4X7Q-B nrPDB Length = 312 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 62/229 (27%), Positives = 106/229 (46%), Gaps = 26/229 (11%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEG-TP----STAIREISLMKE 59 ++++ LG G + TV+ G T + VA+K + + G +P T E++L+ + Sbjct: 31 AEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWK 90 Query: 60 LK----HENIVRLYDVIHTENKLTLVFE--FMDNDLKKYMDSR-TVGNTPRGLELNLVKY 112 + H ++RL D T+ LV E DL Y+ + +G P + Sbjct: 91 VGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPS-------RC 143 Query: 113 FQWQLLQGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGL-ARAFGIPVNTFSSEVV 170 F Q++ + CH ++HRD+K +N+LI+ +RG KL DFG A P F V Sbjct: 144 FFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRV 203 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLK 219 Y P+ + + ++ +WS G +L +M+ G P D+E L+ Sbjct: 204 ---YSPPEWISRHQYHALPATVWSLGILLYDMVCGD--IPFERDQEILE 247 >2PMN-X nrPDB Length = 348 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 67/262 (25%), Positives = 118/262 (45%), Gaps = 41/262 (15%) Query: 53 EISLMKELKHENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTV--GNTPRGLELNL 109 E+ ++ ++K+E + +I +++ +++E+M+ND + K+ + V N + + + Sbjct: 93 ELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFIPIQV 152 Query: 110 VKYFQWQLLQGLAFCH-ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE 168 +K +L ++ H E I HRD+KP N+L++K G++KL DFG + + Sbjct: 153 IKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEY--MVDKKIKGS 210 Query: 169 VVTLWYRAPDVLMGSRTYS-TSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGT 227 T + P+ +Y+ +DIWS G L M F Sbjct: 211 RGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF------------------ 252 Query: 228 PNESLWPSVTKLPKYNPNIQQRP---PRDLRQVLQPHT--KEPLDGNLM-----DFLHGL 277 SL S+ +L +N NI+ + P D L P T K N + DFL Sbjct: 253 ---SLKISLVEL--FN-NIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLF 306 Query: 278 LQLNPDMRLSAKQALHHPWFAE 299 L+ NP R++++ AL H W A+ Sbjct: 307 LRKNPAERITSEDALKHEWLAD 328 >4GS6-A nrPDB Length = 315 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 76/242 (31%), Positives = 110/242 (45%), Gaps = 35/242 (14%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E +G G + V K K VA+K+++ +SE +R++S + H NIV+LY Sbjct: 15 EVVGRGAFGVVCKA--KWRAKDVAIKQIESESERKAFIVELRQLS---RVNHPNIVKLYG 69 Query: 71 VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLE----LNLVKYFQW--QLLQGLAFC 124 N + LV E Y + ++ N G E W Q QG+A+ Sbjct: 70 A--CLNPVCLVME--------YAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYL 119 Query: 125 HE---NKILHRDLKPQNLLINKRGQ-LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 H ++HRDLKP NLL+ G LK+ DFG A I + +++ W AP+V Sbjct: 120 HSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGT--ACDIQTHMTNNKGSAAWM-APEVF 176 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIM-GTPNESLWPSVTKL 239 GS YS D++S G IL E+IT + F +E F IM N + P + L Sbjct: 177 EGS-NYSEKCDVFSWGIILWEVITRRKPF-----DEIGGPAFRIMWAVHNGTRPPLIKNL 230 Query: 240 PK 241 PK Sbjct: 231 PK 232 >6HV0-A nrPDB Length = 416 Score = 70.9 bits (172), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 76/300 (25%), Positives = 127/300 (42%), Gaps = 59/300 (19%) Query: 13 LGNGTYAT-VYKGL--NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHENIVRL 68 LG+G T VY+G+ N+ V L E S A RE+ L++E +H N++R Sbjct: 16 LGHGAEGTIVYRGMFDNRDVAVKRILPECF--------SFADREVQLLRESDEHPNVIRY 67 Query: 69 YDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLE-LNLVKYFQWQLLQGLAFCHEN 127 + + E L++Y++ + + GLE + L++ Q GLA H Sbjct: 68 FCTEKDRQFQYIAIELCAATLQEYVEQKDFAHL--GLEPITLLQ----QTTSGLAHLHSL 121 Query: 128 KILHRDLKPQNLLI---NKRGQLK--LGDFGLARAFGIPVNTFSSEV---VTLWYRAPDV 179 I+HRDLKP N+LI N G++K + DFGL + + ++FS T + AP++ Sbjct: 122 NIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 181 Query: 180 LM--GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 L + ++DI+S GC+ +I+ G + + Q ++ Sbjct: 182 LSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSL---------- 231 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 L P E D + + ++ ++P R SAK L HP+F Sbjct: 232 ------------------DCLHPEKHE--DVIARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >4PL5-B nrPDB Length = 435 Score = 70.9 bits (172), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 78/302 (25%), Positives = 132/302 (43%), Gaps = 63/302 (20%) Query: 13 LGNGTYAT-VYKGL--NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHENIVRL 68 LG+G T VYKG+ N+ V L E S A RE+ L++E +H N++R Sbjct: 35 LGHGAEGTIVYKGMFDNRDVAVKRILPECF--------SFADREVQLLRESDEHPNVIRY 86 Query: 69 YDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLE-LNLVKYFQWQLLQGLAFCHEN 127 + + E L++Y++ + + GLE + L+ Q GLA H Sbjct: 87 FCTEKDRQFQYIAIELCAATLQEYVEQKDFAHL--GLEPITLLH----QTTSGLAHLHSL 140 Query: 128 KILHRDLKPQNLLI---NKRGQLK--LGDFGLARAFGIPVNTFSSEV---VTLWYRAPDV 179 I+HRDLKP N+L+ N G++K + DFGL + + ++FS T + AP++ Sbjct: 141 NIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEM 200 Query: 180 L----MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 L + TY ++DI+S GC+ +I+ G + + Q + ++G N + Sbjct: 201 LSEDCKDNPTY--TVDIFSAGCVFYYVISEGYHPFGKSLQRQANI---LLGACNLDCF-- 253 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 H+ + D + + ++ ++P R SAK L HP Sbjct: 254 -------------------------HSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHP 288 Query: 296 WF 297 +F Sbjct: 289 FF 290 >2RIO-A nrPDB Length = 434 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 63/219 (28%), Positives = 107/219 (48%), Gaps = 34/219 (15%) Query: 13 LGNGTYATV-YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HENIVRLYD 70 LG G+ TV ++G G VA+K + +D + A+ EI L+ E H N++R Y Sbjct: 23 LGYGSSGTVVFQG--SFQGRPVAVKRMLIDFCD----IALMEIKLLTESDDHPNVIRYYC 76 Query: 71 VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGL--ELNLVKYFQWQLLQGLAFCHENK 128 T+ L + E + +L+ ++S+ V + L E N + + Q+ G+A H K Sbjct: 77 SETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLR-QIASGVAHLHSLK 135 Query: 129 ILHRDLKPQNLLINKRGQLK-------------LGDFGLARAFGIPVNTFSSEVV----T 171 I+HRDLKPQN+L++ + + DFGL + ++F + + T Sbjct: 136 IIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGT 195 Query: 172 LWYRAPDVLMGS------RTYSTSIDIWSCGCILAEMIT 204 +RAP++L S R + SIDI+S GC+ +++ Sbjct: 196 SGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILS 234 >2R2P-A nrPDB Length = 295 Score = 70.5 bits (171), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 54/211 (25%), Positives = 104/211 (49%), Gaps = 13/211 (6%) Query: 13 LGNGTYATVYKGLNKTTG---VYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 +G G + V G K G + VA+K +K+ E + E S+M + H NI+ L Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLE 89 Query: 70 DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 V+ + +V E+M+N +D+ N + + LV + + G+ + + Sbjct: 90 GVVTKSKPVMIVTEYMENG---SLDTFLKKNDGQFTVIQLVGMLR-GISAGMKYLSDMGY 145 Query: 130 LHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSE--VVTLWYRAPDVLMGSRTY 186 +HRDL +N+LIN K+ DFGL+R P +++ + + + AP+ + R + Sbjct: 146 VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-AFRKF 204 Query: 187 STSIDIWSCGCILAEMIT--GKPLFPGTNDE 215 +++ D+WS G ++ E+++ +P + TN + Sbjct: 205 TSASDVWSYGIVMWEVVSYGERPYWEMTNQD 235 >4R7H-A nrPDB Length = 343 Score = 70.5 bits (171), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 102/226 (45%), Gaps = 28/226 (12%) Query: 13 LGNGTYATVYK----GLNKTTGVY-VALKEVKLDSEEGTPSTAIREISLMKEL-KHENIV 66 LG G + V + GL K V VA+K +K + + E+ +M L +HENIV Sbjct: 58 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 117 Query: 67 RLYDVIHTENKLTLVFEFMD-NDLKKYMD---------SRTVGNTPRGL--------ELN 108 L + ++ E+ DL ++ S + G P GL EL Sbjct: 118 NLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELR 177 Query: 109 LVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--S 166 + +F Q+ QG+AF +HRD+ +N+L+ K+GDFGLAR N Sbjct: 178 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKG 237 Query: 167 SEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPG 211 + + + + AP+ + S Y+ D+WS G +L E+ + G +PG Sbjct: 238 NARLPVKWMAPESIFDS-VYTVQSDVWSYGILLWEIFSLGLNPYPG 282 >4P5Q-A nrPDB Length = 361 Score = 70.5 bits (171), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 98/198 (49%), Gaps = 11/198 (5%) Query: 13 LGNGTYATVYKG---LNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 +G G + V G L + VA+K +K+ E + E S+M + H NI+RL Sbjct: 41 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLE 100 Query: 70 DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 V+ + +V E+M+N +DS + + + LV + + G+ + + Sbjct: 101 GVVTKSKPVMIVTEYMENG---SLDSFLRKHDAQFTVIQLVGMLR-GIASGMKYLSDMGY 156 Query: 130 LHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSE--VVTLWYRAPDVLMGSRTY 186 +HRDL +N+LIN K+ DFGL+R P +++ + + + +P+ + R + Sbjct: 157 VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAI-AYRKF 215 Query: 187 STSIDIWSCGCILAEMIT 204 +++ D+WS G +L E+++ Sbjct: 216 TSASDVWSYGIVLWEVMS 233 >5X02-A nrPDB Length = 347 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 65/230 (28%), Positives = 108/230 (46%), Gaps = 36/230 (15%) Query: 13 LGNGTY-----ATVYKGLNKT-TGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHENI 65 LG+G + AT Y G++KT + VA+K +K ++ + E+ +M +L HENI Sbjct: 56 LGSGAFGKVMNATAY-GISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENI 114 Query: 66 VRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLE------------LNLVKY 112 V L + L+FE+ DL Y+ S+ + +E LN++ + Sbjct: 115 VNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTF 174 Query: 113 -----FQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSS 167 F +Q+ +G+ F +HRDL +N+L+ +K+ DFGLAR + + S+ Sbjct: 175 EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLAR----DIMSDSN 230 Query: 168 EVVTLWYRAPDVLMGSRT-----YSTSIDIWSCGCILAEMIT-GKPLFPG 211 VV R P M + Y+ D+WS G +L E+ + G +PG Sbjct: 231 YVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPG 280 >4XUF-A nrPDB Length = 297 Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 65/230 (28%), Positives = 108/230 (46%), Gaps = 36/230 (15%) Query: 13 LGNGTY-----ATVYKGLNKT-TGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHENI 65 LG+G + AT Y G++KT + VA+K +K ++ + E+ +M +L HENI Sbjct: 17 LGSGAFGKVMNATAY-GISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENI 75 Query: 66 VRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLE------------LNLVKY 112 V L + L+FE+ DL Y+ S+ + +E LN++ + Sbjct: 76 VNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTF 135 Query: 113 -----FQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSS 167 F +Q+ +G+ F +HRDL +N+L+ +K+ DFGLAR + + S+ Sbjct: 136 EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLAR----DIMSDSN 191 Query: 168 EVVTLWYRAPDVLMGSRT-----YSTSIDIWSCGCILAEMIT-GKPLFPG 211 VV R P M + Y+ D+WS G +L E+ + G +PG Sbjct: 192 YVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPG 241 >5U6B-A nrPDB Length = 307 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 70/292 (23%), Positives = 126/292 (43%), Gaps = 56/292 (19%) Query: 13 LGNGTYATVYKG-LNKTTGVY-VALKEVKLD-SEEGTPSTAIREISLMKELKHENIVRLY 69 LG G + V +G LN+ + VA+K +K+ + E MKE H N++RL Sbjct: 31 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 90 Query: 70 DVIHTENKL------TLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 V ++ ++ FM + DL ++ +G+ P L ++ F + G+ Sbjct: 91 GVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGME 150 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLA------------RAFGIPVNTFSSEVV 170 + + +HRDL +N ++N+ + + DFGL+ R +PV + E Sbjct: 151 YLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES- 209 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPN 229 + R Y++ D+WS G + E+ T G+ +PG + E I+D + N Sbjct: 210 ----------LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSE----IYDYLRQGN 255 Query: 230 ---------ESLWPSVTKLPKYNPNIQQRPP-RDLRQVLQ------PHTKEP 265 + L+ +++ + NP Q RP +LR+ L+ P +EP Sbjct: 256 RLKQPADCLDGLYALMSRCWELNP--QDRPSFTELREDLENTLKALPPAQEP 305 >4CRS-A nrPDB Length = 341 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 76/305 (24%), Positives = 133/305 (43%), Gaps = 59/305 (19%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVK-----LDSEEGTPSTAIREISLMKELK 61 F+ L G + V K T A+K +K E + R + ++ Sbjct: 14 FRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVR 73 Query: 62 HENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H +V L+ T+ + V E+ DL ++ + V + PR + ++ ++ G Sbjct: 74 HPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPRAV------FYAACVVLG 126 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLAR---AFGIPVNTFSSEVVTLWYRAP 177 L + HE+KI++RDLK NLL++ G +K+ DFGL + +G +TF T + AP Sbjct: 127 LQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCG---TPEFLAP 183 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +VL + +Y+ ++D W G ++ EM+ G+ FPG ++EE +FD S+ Sbjct: 184 EVLTET-SYTRAVDWWGLGVLIYEMLVGESPFPGDDEEE----VFD-------SIVNDEV 231 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ-----AL 292 + P++ L + + LL+ NP+ RL A + Sbjct: 232 RYPRF-----------------------LSTEAISIMRRLLRRNPERRLGASEKDAEDVK 268 Query: 293 HHPWF 297 HP+F Sbjct: 269 KHPFF 273 >5B2L-A nrPDB Length = 324 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/228 (24%), Positives = 108/228 (47%), Gaps = 16/228 (7%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISL-MKELKHE 63 + + L ++G+GT V+K + TG +A+K+++ + + ++ + +K Sbjct: 17 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 76 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 IV+ + T + + E M +K + R G P ++ +++ L + Sbjct: 77 YIVQCFGTFITNTDVFIAMELMGTSAEK-LKKRMQGPIPE----RILGKMTVAIVKALYY 131 Query: 124 CHE-NKILHRDLKPQNLLINKRGQLKLGDFGLA-RAFGIPVNTFSSEVVTLWYRAPDVL- 180 E + ++HRD+KP N+L+++RGQ+KL DFG++ R T S+ Y AP+ + Sbjct: 132 LKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAA--YMAPERID 189 Query: 181 ---MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIM 225 Y D+WS G L E+ TG+ FP N + +++ ++ Sbjct: 190 PPDPTKPDYDIRADVWSLGISLVELATGQ--FPYKNCKTDFEVLTKVL 235 >2Y6O-A nrPDB Length = 291 Score = 68.9 bits (167), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 50/207 (24%), Positives = 101/207 (48%), Gaps = 11/207 (5%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTG---VYVALKEVKLDSEEGTPSTAIREISLMKEL 60 +S K + +G G + V G K G + VA+K +K + + E S+M + Sbjct: 13 ASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQF 72 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H NI+ L V+ + ++ E+M+N +D+ N R + LV + + G Sbjct: 73 DHPNIIHLEGVVTKCKPVMIITEYMENG---SLDAFLRKNDGRFTVIQLVGMLR-GIGSG 128 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSE--VVTLWYRAP 177 + + + +HRDL +N+L+N K+ DFG++R P +++ + + + AP Sbjct: 129 MKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAP 188 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMIT 204 + + R ++++ D+WS G ++ E+++ Sbjct: 189 EAI-AYRKFTSASDVWSYGIVMWEVMS 214 >6BSD-A nrPDB Length = 876 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 53/232 (22%), Positives = 109/232 (46%), Gaps = 35/232 (15%) Query: 5 SQFKQLEKLGNGTYATVYK----------------GLNKTTGVYVALKEVKLDSEEGTPS 48 S+ + EKLG G + V+ + K + VA+K ++ D+ + + Sbjct: 571 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARN 630 Query: 49 TAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTV--------- 98 ++E+ +M LK NI+RL V ++ L ++ ++M+N DL +++ + + Sbjct: 631 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAP 690 Query: 99 --GNTPRGLELN--LVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGL 154 G +G ++ ++ + Q+ G+ + +HRDL +N L+ + +K+ DFG+ Sbjct: 691 GDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGM 750 Query: 155 ARAF--GIPVNTFSSEVVTL-WYRAPDVLMGSRTYSTSIDIWSCGCILAEMI 203 +R G V+ + W +LMG ++T+ D+W+ G L E++ Sbjct: 751 SRNLYAGDYYRVQGRAVLPIRWMAWECILMGK--FTTASDVWAFGVTLWEVL 800 >4H1J-A nrPDB Length = 293 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 63/249 (25%), Positives = 118/249 (47%), Gaps = 20/249 (8%) Query: 13 LGNGTYATVYKGL---NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 LG G + VY+G+ +K + VA+K K D + E +MK L H +IV+L Sbjct: 32 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLI 91 Query: 70 DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 +I E ++ + +L Y++ N+ + L L L + Q+ + +A+ Sbjct: 92 GIIEEEPTWIIMELYPYGELGHYLERNK--NSLKVLTLVL---YSLQICKAMAYLESINC 146 Query: 130 LHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVT---LWYRAPDVLMGSRTY 186 +HRD+ +N+L+ +KLGDFGL+R I + VT + + +P+ + R + Sbjct: 147 VHRDIAVRNILVASPECVKLGDFGLSRY--IEDEDYYKASVTRLPIKWMSPESI-NFRRF 203 Query: 187 STSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV-----TKLP 240 +T+ D+W + E+++ GK F +++ + ++ P L P V T+ Sbjct: 204 TTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCW 263 Query: 241 KYNPNIQQR 249 Y+P+ + R Sbjct: 264 DYDPSDRPR 272 >4FR4-A nrPDB Length = 384 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 50/206 (24%), Positives = 95/206 (46%), Gaps = 14/206 (6%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKHEN 64 F+ L +G G++ V T A+K + E +E+ +M+ L+H Sbjct: 17 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPF 76 Query: 65 IVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 +V L+ E + +V + + DL+ ++ + VK F +L+ L + Sbjct: 77 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV------HFKEETVKLFICELVMALDY 130 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT-FSSEVVTLWYRAPDVLMG 182 +I+HRD+KP N+L+++ G + + DF +A +P T ++ T Y AP++ Sbjct: 131 LQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAM--LPRETQITTMAGTKPYMAPEMFSS 188 Query: 183 SR--TYSTSIDIWSCGCILAEMITGK 206 + YS ++D WS G E++ G+ Sbjct: 189 RKGAGYSFAVDWWSLGVTAYELLRGR 214 >6FEX-A nrPDB Length = 321 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 53/226 (23%), Positives = 107/226 (47%), Gaps = 29/226 (12%) Query: 5 SQFKQLEKLGNGTYATVYKG--------------LNKTTG--VYVALKEVKLDSEEGTPS 48 S+ + EKLG G + V+ LN G + VA+K ++ D+ + + Sbjct: 16 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARN 75 Query: 49 TAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPR---- 103 ++E+ +M LK NI+RL V ++ L ++ ++M+N DL +++ + + + Sbjct: 76 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAP 135 Query: 104 ---GLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF-- 158 + ++ + Q+ G+ + +HRDL +N L+ + +K+ DFG++R Sbjct: 136 GDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYA 195 Query: 159 GIPVNTFSSEVVTL-WYRAPDVLMGSRTYSTSIDIWSCGCILAEMI 203 G V+ + W +LMG ++T+ D+W+ G L E++ Sbjct: 196 GDYYRVQGRAVLPIRWMAWECILMGK--FTTASDVWAFGVTLWEVL 239 >5XD6-A nrPDB Length = 305 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/203 (29%), Positives = 101/203 (49%), Gaps = 13/203 (6%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 72 +G G+Y V+ G+ K+ G A+K KLDS + + ++S++ L+ EN+V L Sbjct: 30 IGEGSYGRVFYGILKS-GKAAAIK--KLDSSKQPDQEFLAQVSMVSRLRQENVVALLGYC 86 Query: 73 HTENKLTLVFEFMDN-DLKKYMDSRT-VGNTPRGLELNLVKYFQWQL--LQGLAFCHENK 128 L +E+ N L + R V G L+ + + + +GL + HE Sbjct: 87 VDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLHEKA 146 Query: 129 ---ILHRDLKPQNLLINKRGQLKLGDFGLA-RAFGIPVNTFSSEVV-TLWYRAPDVLMGS 183 ++HRD+K N+L+ K+ DF L+ +A + S+ V+ T Y AP+ M + Sbjct: 147 NPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYAM-T 205 Query: 184 RTYSTSIDIWSCGCILAEMITGK 206 T ST D++S G +L E++TG+ Sbjct: 206 GTLSTKSDVYSFGVVLLELLTGR 228 >5WNO-A nrPDB Length = 330 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 103/217 (47%), Gaps = 28/217 (12%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGL-----NKTTGVYVALKEVKLDSEEGTPSTAIREISL 56 SS Q K +KLG G + TV+ G+ K + VA+K + D + + E + Sbjct: 19 SSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQ--TDEMLEEATN 76 Query: 57 MKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLEL---NLVKYF 113 M L+H+N++++ + F D+ LK R +GN L+L NL Sbjct: 77 MFRLRHDNLLKI-----------IGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGARE 125 Query: 114 Q----WQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN--TFSS 167 Q +Q+ G+ + + +++HRDL +N+L+ K +++ DFGL++ + T S Sbjct: 126 QVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKS 185 Query: 168 EVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT 204 V + + A ++ Y+ + D+W+ G E+IT Sbjct: 186 GKVAIKWLAIEIF-SKHCYTHASDVWAFGVTCWEIIT 221 >3CJF-A nrPDB Length = 309 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 66/229 (28%), Positives = 109/229 (47%), Gaps = 30/229 (13%) Query: 13 LGNGTYATVYK----GLNKT-TGVYVALKEVKLDSEEGTPSTAIREISLMKELK------ 61 LG G + V + G++KT T VA+K +K EG + R +LM ELK Sbjct: 35 LGRGAFGQVIEADAFGIDKTATCRTVAVKMLK----EGATHSEHR--ALMSELKILIHIG 88 Query: 62 -HENIVRLYDVIHTENK-LTLVFEFMD-NDLKKYMDSRTVGNTPRG------LELNLVKY 112 H N+V L L ++ EF +L Y+ S+ P L L + Sbjct: 89 HHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLIC 148 Query: 113 FQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLAR-AFGIPVNTFSSEV-V 170 + +Q+ +G+ F K +HRDL +N+L++++ +K+ DFGLAR + P + + Sbjct: 149 YSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARL 208 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQL 218 L + AP+ + R Y+ D+WS G +L E+ + G +PG +E+ Sbjct: 209 PLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEF 256 >4NEU-A nrPDB Length = 333 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 57/241 (23%), Positives = 111/241 (46%), Gaps = 21/241 (8%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 SS F + +L +G + V ++T G+ + K + + E +M L+H Sbjct: 23 SSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHS 82 Query: 64 NIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 +V+L VI E K +LV E+M+ +L + + +TP ++ ++ ++++G+ Sbjct: 83 RVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEM--STPLSVKGRII----LEIIEGMC 136 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLA--RAFGIPVNTFSSEVV---------- 170 + H ++H+DLKP+N+L++ +K+ D GLA + + N +E+ Sbjct: 137 YLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNG 196 Query: 171 -TLWYRAPDVLMGSRTYSTS-IDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTP 228 TL+Y AP+ L T D++S +L + K + E+QL + P Sbjct: 197 GTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRP 256 Query: 229 N 229 + Sbjct: 257 D 257 >1VZO-A nrPDB Length = 355 Score = 67.8 bits (164), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 112/221 (50%), Gaps = 18/221 (8%) Query: 7 FKQLEKLGNGTYATVY---KGLNKTTGVYVALKEVK---LDSEEGTPSTAIREISLMKEL 60 F+ L+ LG G Y V+ K TG A+K +K + + T E +++ + Sbjct: 56 FELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHI 115 Query: 61 KHEN-IVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 + +V L+ TE KL L+ ++++ +L ++ R R E + V+ + +++ Sbjct: 116 RQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQR-----ERFTE-HEVQIYVGEIV 169 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-TLWYRAP 177 L H+ I++RD+K +N+L++ G + L DFGL++ F + + T+ Y AP Sbjct: 170 LALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAP 229 Query: 178 DVLMGSRT-YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQ 217 D++ G + + ++D WS G ++ E++TG P T D E+ Sbjct: 230 DIVRGGDSGHDKAVDWWSLGVLMYELLTGAS--PFTVDGEK 268 >4LRM-A nrPDB Length = 334 Score = 67.8 bits (164), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 54/222 (24%), Positives = 102/222 (45%), Gaps = 41/222 (18%) Query: 5 SQFKQLEKLGNGTYATVYKGL----NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 ++FK+++ LG+G + TVYKGL + + VA+KE++ + + E +M + Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 78 Query: 61 KHE---NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVK------ 111 + ++ RL + T + + L+ + M P G L+ V+ Sbjct: 79 DNPGNPHVCRLLGICLT-STVQLITQLM----------------PFGCLLDYVREHKDNI 121 Query: 112 ----YFQW--QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF 165 W Q+ +G+ + + +++HRDL +N+L+ +K+ DFGLA+ G + Sbjct: 122 GSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEY 181 Query: 166 SSE---VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT 204 +E V W +L R Y+ D+WS G + E++T Sbjct: 182 HAEGGKVPIKWMALESIL--HRIYTHQSDVWSYGVTVWELMT 221 >3BBT-B nrPDB Length = 328 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 108/213 (50%), Gaps = 16/213 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALK-EVKLDSEEGTPSTAIR---EISLMKE 59 ++ K+++ LG+G + TVYKG+ G V + +K+ +E P + E +M Sbjct: 14 ETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMAS 73 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 + H ++VRL V + + LV + M + L +Y+ N L LN + Q+ Sbjct: 74 MDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHK-DNIGSQLLLN----WCVQIA 127 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE--VVTLWYRA 176 +G+ + E +++HRDL +N+L+ +K+ DFGLAR ++++ + + + A Sbjct: 128 KGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMA 187 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMIT--GKP 207 + + R ++ D+WS G + E++T GKP Sbjct: 188 LECI-HYRKFTHQSDVWSYGVTIWELMTFGGKP 219 >4JLC-A nrPDB Length = 657 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 71/241 (29%), Positives = 103/241 (42%), Gaps = 30/241 (12%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 72 LG G A V++G +K TG A+K S +RE ++K+L H+NIV+L+ + Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 75 Query: 73 H--TENKLTLVFEFMDNDLKKYMDSRTVGNTPR---GLELNLVKYFQWQLLQGLAFCHEN 127 T L+ EF TV P GL + ++ G+ EN Sbjct: 76 EETTTRHKVLIMEFCPCG-----SLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 130 Query: 128 KILHRDLKPQNLL--INKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 I+HRD+KP N++ I + GQ KL DFG AR F S T Y PD+ + Sbjct: 131 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERA 189 Query: 184 -------RTYSTSIDIWSCGCILAEMITGKPLF-----PGTNDEEQLKLIFDIMGTPNES 231 + Y ++D+WS G TG F P N E K+ I G P+ + Sbjct: 190 VLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKI---ITGKPSGA 246 Query: 232 L 232 + Sbjct: 247 I 247 >4EUT-A nrPDB Length = 396 Score = 67.0 bits (162), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 65/236 (27%), Positives = 105/236 (44%), Gaps = 20/236 (8%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 72 LG G A V++G +K TG A+K S +RE ++K+L H+NIV+L+ + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 76 Query: 73 H--TENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 T L+ EF L ++ + GL + ++ G+ EN I Sbjct: 77 EETTTRHKVLIMEFCPCGSLYTVLEEPS---NAYGLPESEFLIVLRDVVGGMNHLRENGI 133 Query: 130 LHRDLKPQNLL--INKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS-- 183 +HR++KP N++ I + GQ KL DFG AR F S T Y PD+ + Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVL 192 Query: 184 -----RTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIM-GTPNESL 232 + Y ++D+WS G TG P P ++++ I+ G P+ ++ Sbjct: 193 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAI 248 >5VO2-A nrPDB Length = 300 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/197 (27%), Positives = 93/197 (47%), Gaps = 17/197 (8%) Query: 10 LEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 L+ +G+G V+ L + G VA+K+V+ D +E +I +++LKH NI+ Sbjct: 17 LQWVGSGAQGAVF--LGRFHGEEVAVKKVR-DLKE-------TDIKHLRKLKHPNIITFK 66 Query: 70 DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 V ++ EF V R + +L+ + + G+ + H +KI Sbjct: 67 GVCTQAPCYCILMEFCAQG-----QLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKI 121 Query: 130 LHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTS 189 +HRDLK N+LI +K+ DFG ++ S W AP+V+ + S Sbjct: 122 IHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWM-APEVIR-NEPVSEK 179 Query: 190 IDIWSCGCILAEMITGK 206 +DIWS G +L E++TG+ Sbjct: 180 VDIWSFGVVLWELLTGE 196 >5TE0-A nrPDB Length = 347 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 66/212 (31%), Positives = 99/212 (46%), Gaps = 26/212 (12%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HENIVRLY 69 E L G +A V+ + + G+ ALK + +++E REI +M++L H+NIV Sbjct: 25 EVLAEGGFAIVFL-VRTSNGMKCALKRMFVNNEHDL-QVCKREIQIMRDLSGHKNIVGYI 82 Query: 70 DVIHTENKLTLVFE---FMD----NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 D V+E MD + M+ R G N V + +A Sbjct: 83 DSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRL----QTGFTENEVLQIFCDTCEAVA 138 Query: 123 FCHENK--ILHRDLKPQNLLINKRGQLKLGDFGLA-RAFGIP----VNTFSSEV---VTL 172 H+ K I+HRDLK +N+L++ RG L DFG A F P VN E+ TL Sbjct: 139 RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTL 198 Query: 173 WYRAPDV--LMGSRTYSTSIDIWSCGCILAEM 202 YRAP++ L + +T DIW+ GC+L ++ Sbjct: 199 SYRAPEMVNLYSGKIITTKADIWALGCLLYKL 230 >4FL3-A nrPDB Length = 635 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 58/229 (25%), Positives = 112/229 (48%), Gaps = 20/229 (8%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA---IREISLMKELKHENIVR 67 ++LG+G + TV KG + V + L +E P+ + E ++M++L + IVR Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 68 LYDVIHTENKLTLVFEFMD-NDLKKYMD-SRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 + + E+ + LV E + L KY+ +R V + N+++ Q+ G+ + Sbjct: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDK------NIIELVH-QVSMGMKYLE 486 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLMG 182 E+ +HRDL +N+L+ + K+ DFGL++A N + ++ W + AP+ + Sbjct: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-N 545 Query: 183 SRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI--FDIMGTP 228 +S+ D+WS G ++ E + G+ + G E ++ + MG P Sbjct: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 >3FXW-A nrPDB Length = 336 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 53/186 (28%), Positives = 80/186 (43%), Gaps = 42/186 (22%) Query: 120 GLAFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 + F H + I HRD+KP+NLL K LKL DFG A+ N + T +Y A Sbjct: 140 AIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKE--TTQNALQTPCYTPYYVA 197 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEE-----QLKLIFDIMGTPNES 231 P+VL G Y S D+WS G I+ ++ G P F + + ++ G PN Sbjct: 198 PEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPE 256 Query: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 W V++ D +Q+++ LL+ +P RL+ Q Sbjct: 257 -WSEVSE--------------DAKQLIRL----------------LLKTDPTERLTITQF 285 Query: 292 LHHPWF 297 ++HPW Sbjct: 286 MNHPWI 291 >4C59-A nrPDB Length = 340 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 78/310 (25%), Positives = 127/310 (40%), Gaps = 71/310 (22%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HENIVRLYDV 71 L G +A VY+ + +G ALK + L +EE I+E+ MK+L H NIV+ Sbjct: 35 LAEGGFAFVYEAQDVGSGREYALKRL-LSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSA 93 Query: 72 IHT--------ENKLTLVFEFMDNDLKKY---MDSRTVGNTPRGLELNLVKYFQWQLLQG 120 + + L+ E L ++ M+SR L + V +Q + Sbjct: 94 ASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGP------LSCDTVLKIFYQTCRA 147 Query: 121 LAFCHENK--ILHRDLKPQNLLINKRGQLKLGDFGLARAFG-IPVNTFSSEVVTL----- 172 + H K I+HRDLK +NLL++ +G +KL DFG A P ++S++ L Sbjct: 148 VQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEI 207 Query: 173 ------WYRAPDV--LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDI 224 YR P++ L + DIW+ GCIL + + F D +L+++ Sbjct: 208 TRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPF---EDGAKLRIVNG- 263 Query: 225 MGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDM 284 KY+ PP D + + + +LQ+NP+ Sbjct: 264 ----------------KYSI-----PPHDTQYTV-----------FHSLIRAMLQVNPEE 291 Query: 285 RLSAKQALHH 294 RLS + +H Sbjct: 292 RLSIAEVVHQ 301 >2QKW-B nrPDB Length = 321 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 54/197 (27%), Positives = 97/197 (49%), Gaps = 8/197 (4%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 72 +G+G + VYKG+ + G VALK +S +G +L +H ++V L Sbjct: 47 IGHGVFGKVYKGVLRD-GAKVALKRRTPESSQGIEEFETEIETL-SFCRHPHLVSLIGFC 104 Query: 73 HTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 N++ L++++M+N +LK+++ + E L +GL + H I+H Sbjct: 105 DERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRL--EICIGAARGLHYLHTRAIIH 162 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV--TLWYRAPDVLMGSRTYSTS 189 RD+K N+L+++ K+ DFG+++ T S VV TL Y P+ + R S Sbjct: 163 RDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRLTEKS 222 Query: 190 IDIWSCGCILAEMITGK 206 D++S G +L E++ + Sbjct: 223 -DVYSFGVVLFEVLCAR 238 >5IKW-A nrPDB Length = 310 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 69/212 (32%), Positives = 109/212 (51%), Gaps = 27/212 (12%) Query: 11 EKLGNGTYATVYKGLNKT-TGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HENIVRL 68 E L G ++TV+ L +T G+ ALK + +++ + REI++MKEL H+NIV Sbjct: 20 ESLAEGGFSTVF--LVRTHGGIRCALKRMYVNNMPDL-NVCKREITIMKELSGHKNIVGY 76 Query: 69 YDVIHTENKLT-LVFEFMDNDLKKYMDS-RTVGNTPRGLELNLVKYFQWQLL----QGLA 122 D N ++ V+E + L +Y + + V + L+ + Q+ + +A Sbjct: 77 LDC--AVNSISDNVWEVLI--LMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVA 132 Query: 123 FCHENK--ILHRDLKPQNLLINKRGQLKLGDFGLA-RAFGIP----VNTFSSEV---VTL 172 H+ K I+HRDLK +N+L+N G L DFG A F P VN E+ TL Sbjct: 133 RLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTL 192 Query: 173 WYRAPDV--LMGSRTYSTSIDIWSCGCILAEM 202 YRAP++ L G + +T DIW+ GC+L ++ Sbjct: 193 SYRAPEMINLYGGKPITTKADIWALGCLLYKL 224 >4EUU-A nrPDB Length = 319 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 65/236 (27%), Positives = 105/236 (44%), Gaps = 20/236 (8%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 72 LG G A V++G +K TG A+K S +RE ++K+L H+NIV+L+ + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 76 Query: 73 H--TENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 T L+ EF L ++ + GL + ++ G+ EN I Sbjct: 77 EETTTRHKVLIMEFCPCGSLYTVLEEPS---NAYGLPESEFLIVLRDVVGGMNHLRENGI 133 Query: 130 LHRDLKPQNLL--INKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS-- 183 +HR++KP N++ I + GQ KL DFG AR F S T Y PD+ + Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVL 192 Query: 184 -----RTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIM-GTPNESL 232 + Y ++D+WS G TG P P ++++ I+ G P+ ++ Sbjct: 193 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAI 248 >5C26-A nrPDB Length = 299 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/229 (25%), Positives = 112/229 (48%), Gaps = 20/229 (8%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA---IREISLMKELKHENIVR 67 ++LG+G + TV KG + V + L +E P+ + E ++M++L + IVR Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 68 LYDVIHTENKLTLVFEFMD-NDLKKYMD-SRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 + + E+ + LV E + L KY+ +R V + N+++ Q+ G+ + Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDK------NIIELVH-QVSMGMKYLE 144 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLMG 182 E+ +HRDL +N+L+ + K+ DFGL++A N + ++ W + AP+ + Sbjct: 145 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-N 203 Query: 183 SRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI--FDIMGTP 228 +S+ D+WS G ++ E + G+ + G E ++ + MG P Sbjct: 204 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 252 >5HIE-A nrPDB Length = 302 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 60/243 (24%), Positives = 120/243 (49%), Gaps = 21/243 (8%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 +++G+G++ TVYKG K G VA+K + + + E+ ++++ +H NI+ L+ Sbjct: 42 QRIGSGSFGTVYKG--KWHG-DVAVKMLTPQQLQAFKN----EVGVLRKTRHVNIL-LFM 93 Query: 71 VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 T+ +L +V ++ + Y + ++L + Q QG+ + H I+ Sbjct: 94 GYSTKPQLAIVTQWCEGS-SLYHHLHIIETKFEMIKLIDIAR---QTAQGMDYLHAKSII 149 Query: 131 HRDLKPQNLLINKRGQLKLGDFGLA--RAFGIPVNTFSSEVVTLWYRAPDV--LMGSRTY 186 HRDLK N+ +++ +K+GDFGLA ++ + F ++ + AP+V + Y Sbjct: 150 HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPY 209 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNI 246 S D+++ G +L E++TG+ + N+ +Q+ I L P ++K+ P Sbjct: 210 SFQSDVYAFGIVLYELMTGQLPYSNINNRDQI-----IFMVGRGYLSPDLSKVRSNCPKA 264 Query: 247 QQR 249 +R Sbjct: 265 MKR 267 >6NT9-A nrPDB Length = 742 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 68/230 (29%), Positives = 98/230 (42%), Gaps = 27/230 (11%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 72 LG G A V++G +K TG A+K S +RE ++K+L H+NIV+L+ + Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 Query: 73 H--TENKLTLVFEFMDNDLKKYMDSRTVGNTPR---GLELNLVKYFQWQLLQGLAFCHEN 127 T L+ EF TV P GL + ++ G+ EN Sbjct: 75 EETTTRHKVLIMEFCPCG-----SLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 Query: 128 KILHRDLKPQNLL--INKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 I+HR++KP N++ I + GQ KL DFG AR F S T Y PD+ + Sbjct: 130 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVSLYGTEEYLHPDMYERA 188 Query: 184 -------RTYSTSIDIWSCGCILAEMITGKPLF-----PGTNDEEQLKLI 221 + Y ++D+WS G TG F P N E K+I Sbjct: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 >3KUL-B nrPDB Length = 325 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 97/204 (47%), Gaps = 14/204 (6%) Query: 9 QLEKL-GNGTYATVYKGLNKTTG---VYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 +EK+ G+G V G + G V VA+K +K E + E S+M + H N Sbjct: 52 HIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPN 111 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 I+RL V+ +V E+M+N +D+ + + + LV + + G+ + Sbjct: 112 IIRLEGVVTRGRLAMIVTEYMEN---GSLDTFLRTHDGQFTIMQLVGMLR-GVGAGMRYL 167 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAF----GIPVNTFSSEVVTLWYRAPDVL 180 + +HRDL +N+L++ K+ DFGL+R T ++ W AP+ + Sbjct: 168 SDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWT-APEAI 226 Query: 181 MGSRTYSTSIDIWSCGCILAEMIT 204 RT+S++ D+WS G ++ E++ Sbjct: 227 -AFRTFSSASDVWSFGVVMWEVLA 249 >1NY3-A nrPDB Length = 400 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 75/295 (25%), Positives = 117/295 (39%), Gaps = 45/295 (15%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISL-MKELKHENIVRLYDV 71 LG G V + NK T ALK + + P A RE+ L + + +IVR+ DV Sbjct: 70 LGLGINGKVLQIFNKRTQEKFALKML-----QDCPK-ARREVELHWRASQCPHIVRIVDV 123 Query: 72 IHT----ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 L +V E +D + SR + + + + + H Sbjct: 124 YENLYAGRKCLLIVMECLDGG---ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 Query: 128 KILHRDLKPQNLLINKR---GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 I HRD+KP+NLL + LKL DFG A+ N+ ++ T +Y AP+VL G Sbjct: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEVL-GPE 238 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 Y S D+WS G I+ ++ G P F N L S P Sbjct: 239 KYDKSCDMWSLGVIMYILLCGYPPF-----------------YSNHGLAIS--------P 273 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 ++ R + P E + + + LL+ P R++ + ++HPW + Sbjct: 274 GMKTRIRMGQYEFPNPEWSE-VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 >2OZA-A nrPDB Length = 356 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 75/295 (25%), Positives = 117/295 (39%), Gaps = 45/295 (15%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLM-KELKHENIVRLYDV 71 LG G V + NK T ALK + + P A RE+ L + + +IVR+ DV Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKML-----QDCPK-ARREVELHWRASQCPHIVRIVDV 79 Query: 72 IHT----ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 L +V E +D + SR + + + + + H Sbjct: 80 YENLYAGRKCLLIVMECLDGG---ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 136 Query: 128 KILHRDLKPQNLLINKR---GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 I HRD+KP+NLL + LKL DFG A+ N+ ++ T +Y AP+VL G Sbjct: 137 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEVL-GPE 194 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 Y S D+WS G I+ ++ G P F N L S P Sbjct: 195 KYDKSCDMWSLGVIMYILLCGYPPF-----------------YSNHGLAIS--------P 229 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 ++ R + P E + + + LL+ P R++ + ++HPW + Sbjct: 230 GMKTRIRMGQYEFPNPEWSE-VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 283 >3AOX-A nrPDB Length = 344 Score = 65.1 bits (157), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 54/225 (24%), Positives = 102/225 (45%), Gaps = 14/225 (6%) Query: 10 LEKLGNGTYATVYKGL-----NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 + LG+G + VY+G N + + VA+K + E + E ++ + H+N Sbjct: 52 IRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQN 111 Query: 65 IVRLYDVIHTENKLTLVFEFM-DNDLKKYM-DSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 IVR V ++ E M DLK ++ ++R + P L + + + + G Sbjct: 112 IVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQ 171 Query: 123 FCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAF--GIPVNTFSSEVVTLWYRAP 177 + EN +HRD+ +N L+ G K+GDFG+AR ++ + + P Sbjct: 172 YLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPP 231 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 + M +++ D WS G +L E+ + G +P +++E L+ + Sbjct: 232 EAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV 275 >5U6C-A nrPDB Length = 315 Score = 65.1 bits (157), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 57/227 (25%), Positives = 97/227 (42%), Gaps = 34/227 (14%) Query: 13 LGNGTYATVYKGLNKT---TGVYVALKEVKLD-SEEGTPSTAIREISLMKELKHENIVRL 68 LG G + +V +G K T + VA+K +KLD S + + E + MK+ H N++RL Sbjct: 44 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVMRL 103 Query: 69 YDVIHTEN-----KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 V + K ++ FM DL Y+ + P+ + L + F + G+ Sbjct: 104 LGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGME 163 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLA------------RAFGIPVNTFSSEVV 170 + LHRDL +N ++ + + DFGL+ R +PV + E Sbjct: 164 YLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIES- 222 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEE 216 + R Y++ D+W+ G + E+ T G +PG + E Sbjct: 223 ----------LADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHE 259 >3KA0-A nrPDB Length = 320 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 74/295 (25%), Positives = 116/295 (39%), Gaps = 45/295 (15%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISL-MKELKHENIVRLYDV 71 LG G V + NK T ALK + + P A RE+ L + + +IVR+ DV Sbjct: 24 LGLGINGKVLQIFNKRTQEKFALKML-----QDCPK-ARREVELHWRASQCPHIVRIVDV 77 Query: 72 IHT----ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 L +V E +D + SR + + + + + H Sbjct: 78 YENLYAGRKCLLIVMECLDGG---ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 134 Query: 128 KILHRDLKPQNLLINKR---GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 I HRD+KP+NLL + LKL DFG A+ N+ + T +Y AP+VL G Sbjct: 135 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTEPCYTPYYVAPEVL-GPE 192 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 Y S D+WS G I+ ++ G P F N L +P Sbjct: 193 KYDKSCDMWSLGVIMYILLCGYPPF-----------------YSNHGL--------AISP 227 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 ++ R + P E + + + LL+ P R++ + ++HPW + Sbjct: 228 GMKTRIRMGQYEFPNPEWSE-VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 281 >3BEA-A nrPDB Length = 333 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 60/217 (27%), Positives = 98/217 (45%), Gaps = 19/217 (8%) Query: 13 LGNGTYATVYK----GLNKTTGVY-VALKEVKLDSEEGTPSTAIREISLMKEL-KHENIV 66 LG G + V + GL K V VA+K +K + + E+ +M L +HENIV Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 113 Query: 67 RLYDVIHTENKLTLVFEFMD-NDLKKYM--DSRTVGNTP------RGLELNLVKYFQWQL 117 L + ++ E+ DL ++ SR + P L + +F Q+ Sbjct: 114 NLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQV 173 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVTLWYR 175 QG+AF +HRD+ +N+L+ K+GDFGLAR N + + + + Sbjct: 174 AQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWM 233 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPG 211 AP+ + Y+ D+WS G +L E+ + G +PG Sbjct: 234 APESIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPG 269 >4X3F-A nrPDB Length = 337 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 35/97 (36%), Positives = 53/97 (54%), Gaps = 2/97 (2%) Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWY 174 Q + L H ++HRD+KP N+LI GQ+K+ DFG+A+A PV + T Y Sbjct: 125 QTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQY 184 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG 211 AP+ +G S + D++S G + E ++GK F G Sbjct: 185 IAPEQALG-HDASPASDVYSLGVVGYEAVSGKRPFAG 220 >4OW8-A nrPDB Length = 283 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 35/97 (36%), Positives = 53/97 (54%), Gaps = 2/97 (2%) Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWY 174 Q + L H ++HRD+KP N+LI GQ+K+ DFG+A+A PV + T Y Sbjct: 124 QTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQY 183 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG 211 AP+ +G S + D++S G + E ++GK F G Sbjct: 184 IAPEQALG-HDASPASDVYSLGVVGYEAVSGKRPFAG 219 >6B2Q-A nrPDB Length = 317 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 35/97 (36%), Positives = 52/97 (53%), Gaps = 2/97 (2%) Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWY 174 Q + L H ++HRD+KP N+LI GQ+K+ DFG+A+A PV + T Y Sbjct: 145 QTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQY 204 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG 211 AP+ +G S D++S G + E ++GK F G Sbjct: 205 IAPEQALGHDASPAS-DVYSLGVVGYEAVSGKRPFAG 240 >3KRL-A nrPDB Length = 335 Score = 64.3 bits (155), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 60/223 (26%), Positives = 99/223 (44%), Gaps = 29/223 (13%) Query: 13 LGNGTYATVYK----GLNKTTGVY-VALKEVKLDSEEGTPSTAIREISLMKEL-KHENIV 66 LG G + V + GL K V VA+K +K + + E+ +M L +HENIV Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 113 Query: 67 RLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNL--------------VK 111 L + ++ E+ DL ++ + P GLE + + Sbjct: 114 NLLGACTHGGPVLVITEYCCYGDLLNFLRRKR----PPGLEYSYNPSHNPEEQLSSRDLL 169 Query: 112 YFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEV 169 +F Q+ QG+AF +HRD+ +N+L+ K+GDFGLAR N + Sbjct: 170 HFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNAR 229 Query: 170 VTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPG 211 + + + AP+ + Y+ D+WS G +L E+ + G +PG Sbjct: 230 LPVKWMAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPG 271 >2BUJ-A nrPDB Length = 317 Score = 64.3 bits (155), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 60/219 (27%), Positives = 98/219 (44%), Gaps = 31/219 (14%) Query: 10 LEKLGNG--TYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVR 67 ++KLG G +Y + +GL+ G + ALK + L E+ A RE + + H NI+R Sbjct: 34 IQKLGEGGFSYVDLVEGLHD--GHFYALKRI-LCHEQQDREEAQREADMHRLFNHPNILR 90 Query: 68 LYDVIHTE----NKLTLVFEFMD-----NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 L E ++ L+ F N++++ D GN L + + + + Sbjct: 91 LVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDK---GNF---LTEDQILWLLLGIC 144 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPV---------NTFSSEV 169 +GL H HRDLKP N+L+ GQ L D G I V ++++ Sbjct: 145 RGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQR 204 Query: 170 VTLWYRAPDV--LMGSRTYSTSIDIWSCGCILAEMITGK 206 T+ YRAP++ + D+WS GC+L M+ G+ Sbjct: 205 CTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGE 243 >6O8B-A nrPDB Length = 665 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 67/239 (28%), Positives = 103/239 (43%), Gaps = 26/239 (10%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVI 72 LG G A V++G +K TG A+K S +RE ++K+L H+NIV+L+ + Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAI- 81 Query: 73 HTENKLTLVFEFMDNDLKKYMDSRTVGNTPR---GLELNLVKYFQWQLLQGLAFCHENKI 129 E + T + + + TV P GL + ++ G+ EN I Sbjct: 82 --EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 139 Query: 130 LHRDLKPQNLL--INKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS-- 183 +HR++KP N++ I + GQ KL DFG AR F T Y PD+ + Sbjct: 140 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVELYGTEEYLHPDMYERAVL 198 Query: 184 -----RTYSTSIDIWSCGCILAEMITGKPLF-----PGTNDEEQLKLIFDIMGTPNESL 232 + Y ++D+WS G TG F P N E K+ I G P+ ++ Sbjct: 199 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI---ITGKPSGAI 254 >6ED6-A nrPDB Length = 415 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 51/187 (27%), Positives = 81/187 (43%), Gaps = 15/187 (8%) Query: 65 IVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 +V+L+ + L +V E+M DL M + V K++ +++ L Sbjct: 150 VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPE-------KWAKFYTAEVVLALDA 202 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFG-IPVNTFSSEVVTLWYRAPDVLM- 181 H ++HRD+KP N+L++K G LKL DFG + + V T Y +P+VL Sbjct: 203 IHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKS 262 Query: 182 --GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 G Y D WS G L EM+ G F + + IM N +P ++ Sbjct: 263 QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYA---DSLVGTYSKIMDHKNSLCFPEDAEI 319 Query: 240 PKYNPNI 246 K+ N+ Sbjct: 320 SKHAKNL 326 >3PP0-A nrPDB Length = 338 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 50/219 (22%), Positives = 100/219 (45%), Gaps = 38/219 (17%) Query: 5 SQFKQLEKLGNGTYATVYKGL----NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 ++ ++++ LG+G + TVYKG+ + + VA+K ++ ++ + E +M + Sbjct: 17 TELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGV 76 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVK--------- 111 + RL + T + + LV + M P G L+ V+ Sbjct: 77 GSPYVSRLLGICLT-STVQLVTQLM----------------PYGCLLDHVRENRGRLGSQ 119 Query: 112 -YFQW--QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE 168 W Q+ +G+++ + +++HRDL +N+L+ +K+ DFGLAR I + ++ Sbjct: 120 DLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHAD 179 Query: 169 ---VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT 204 V W +L R ++ D+WS G + E++T Sbjct: 180 GGKVPIKWMALESIL--RRRFTHQSDVWSYGVTVWELMT 216 >5GRN-A nrPDB Length = 356 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/229 (26%), Positives = 102/229 (44%), Gaps = 31/229 (13%) Query: 13 LGNGTYATVYKG----LNKTTGVY-VALKEVKLDSEEGTPSTAIREISLMKELK-HENIV 66 LG+G + V +G L+++ V VA+K +K + + E+ +M L H NIV Sbjct: 54 LGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIV 113 Query: 67 RLYDVIHTENKLTLVFE-----------------FMDNDLKKYMDSRT----VGNTPRGL 105 L + ++ E F+ + K +DS + GL Sbjct: 114 NLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGL 173 Query: 106 ELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF 165 L + F +Q+ +G+ F +HRDL +N+L+ + +K+ DFGLAR N Sbjct: 174 TLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYV 233 Query: 166 S--SEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPG 211 S S + + + AP+ + Y+T D+WS G +L E+ + G +PG Sbjct: 234 SKGSTFLPVKWMAPESIF-DNLYTTLSDVWSYGILLWEIFSLGGTPYPG 281 >3PLS-A nrPDB Length = 298 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 93/205 (45%), Gaps = 16/205 (7%) Query: 13 LGNGTYATVYKGL---NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 +G G + VY G + A+K + +E +RE LM+ L H N++ L Sbjct: 29 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALI 88 Query: 70 DVIHTENKL--TLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 ++ L L+ DL +++ S T + L F Q+ +G+ + E Sbjct: 89 GIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDL-----ISFGLQVARGMEYLAEQ 143 Query: 128 KILHRDLKPQNLLINKRGQLKLGDFGLARAF----GIPVNTFSSEVVTLWYRAPDVLMGS 183 K +HRDL +N ++++ +K+ DFGLAR V + + + A + L Sbjct: 144 KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTY 203 Query: 184 RTYSTSIDIWSCGCILAEMIT-GKP 207 R ++T D+WS G +L E++T G P Sbjct: 204 R-FTTKSDVWSFGVLLWELLTRGAP 227 >6BXI-A nrPDB Length = 333 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 104/254 (40%), Gaps = 43/254 (16%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIR-EISLMKELKHEN 64 F+ L+ +G G + V K TG A+K + K D E IR E ++ E Sbjct: 8 FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW 67 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 +V+++ + L L+ EF+ D T+ L +++ + + + Sbjct: 68 VVKMFYSFQDKLNLYLIMEFLPGG-----DMMTLLMKKDTLTEEETQFYIAETVLAIDSI 122 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAF--------------GIPVN-TFS--- 166 H+ +HRD+KP NLL++ +G +KL DFGL +P + TF Sbjct: 123 HQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMN 182 Query: 167 -----------------SEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLF 209 S V T Y AP+V M + Y+ D WS G I+ EM+ G P F Sbjct: 183 SKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQT-GYNKLCDWWSLGVIMYEMLIGYPPF 241 Query: 210 PGTNDEEQLKLIFD 223 +E K + + Sbjct: 242 CSETPQETYKKVMN 255 >6E9W-A nrPDB Length = 443 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 93/213 (43%), Gaps = 14/213 (6%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAI-REISLMKELK 61 + ++ ++ +G G + V +K+T A+K + K + + + S E +M Sbjct: 101 AEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN 160 Query: 62 HENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +V+L+ + L +V E+M DL M + V +++ +++ Sbjct: 161 SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPE-------KWARFYTAEVVLA 213 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIP-VNTFSSEVVTLWYRAPDV 179 L H +HRD+KP N+L++K G LKL DFG + + V T Y +P+V Sbjct: 214 LDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEV 273 Query: 180 LM---GSRTYSTSIDIWSCGCILAEMITGKPLF 209 L G Y D WS G L EM+ G F Sbjct: 274 LKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPF 306 >3QD2-B nrPDB Length = 332 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 64/291 (21%), Positives = 119/291 (40%), Gaps = 81/291 (27%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKE----- 59 + F+ ++ +G G + V++ NK A+K ++L + E +RE+ + + Sbjct: 6 TDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 65 Query: 60 ------------------------LKHENI----------------VRLYDVIHTEN--- 76 LK E+ +R D T+N Sbjct: 66 IVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVG 125 Query: 77 -------KLTLVFEFM---DNDLKKYMDSR-TVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 K+ L + +LK +M+ R ++ + G+ L++ Q+ + + F H Sbjct: 126 QLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIF----IQIAEAVEFLH 181 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFG-----------IPV-NTFSSEVVTLW 173 ++HRDLKP N+ +K+GDFGL A +P T + +V T Sbjct: 182 SKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKL 241 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDI 224 Y +P+ + G+ YS +DI+S G IL E+ L+ + E++++I D+ Sbjct: 242 YMSPEQIHGN-NYSHKVDIFSLGLILFEL-----LYSFSTQMERVRIITDV 286 >2QLU-A nrPDB Length = 314 Score = 60.5 bits (145), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 71/260 (27%), Positives = 110/260 (42%), Gaps = 33/260 (12%) Query: 10 LEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 LE G + V+K + +VA+K L ++ S REI +KHEN+++ Sbjct: 20 LEIKARGRFGCVWKA--QLMNDFVAVKIFPLQDKQSWQSE--REIFSTPGMKHENLLQFI 75 Query: 70 DV----IHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 + E +L L+ F D L Y+ GN + N + + + +GL++ Sbjct: 76 AAEKRGSNLEVELWLITAFHDKGSLTDYLK----GNI---ITWNELCHVAETMSRGLSYL 128 Query: 125 HEN-----------KILHRDLKPQNLLINKRGQLKLGDFGLARAF--GIPVNTFSSEVVT 171 HE+ I HRD K +N+L+ L DFGLA F G P +V T Sbjct: 129 HEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGT 188 Query: 172 LWYRAPDVLMGS----RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGT 227 Y AP+VL G+ R ID+++ G +L E+++ G DE L +I Sbjct: 189 RRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQH 248 Query: 228 PNESLWPSVTKLPKYNPNIQ 247 P+ V K P I+ Sbjct: 249 PSLEELQEVVVHKKMRPTIK 268 >3QUP-A nrPDB Length = 323 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 55/226 (24%), Positives = 100/226 (44%), Gaps = 17/226 (7%) Query: 6 QFKQLEKLGNGTYATVYKG-LNKTTG--VYVALKEVKLDSEEGTP-STAIREISLMKELK 61 QF LG G + +V + L + G V VA+K +K D + +RE + MKE Sbjct: 24 QFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFD 83 Query: 62 HENIVRLYDV-IHTENKLTL-----VFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQ 114 H ++ +L V + + K L + FM + DL ++ + +G P L L + F Sbjct: 84 HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFM 143 Query: 115 WQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF---GIPVNTFSSEVVT 171 + G+ + +HRDL +N ++ + + + DFGL+R +S++ Sbjct: 144 VDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPV 203 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEE 216 W + Y+ D+W+ G + E++T G+ + G + E Sbjct: 204 KWLALES--LADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAE 247 >3HNG-A nrPDB Length = 360 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 41/135 (30%), Positives = 73/135 (54%), Gaps = 6/135 (4%) Query: 87 NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQ 146 +D+++ DS P +E +L+ Y +Q+ +G+ F K +HRDL +N+L+++ Sbjct: 180 SDVEEEEDSDGFYKEPITME-DLISY-SFQVARGMEFLSSRKCIHRDLAARNILLSENNV 237 Query: 147 LKLGDFGLAR-AFGIPVNTFSSEV-VTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT 204 +K+ DFGLAR + P + + L + AP+ + + YST D+WS G +L E+ + Sbjct: 238 VKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIF-DKIYSTKSDVWSYGVLLWEIFS 296 Query: 205 -GKPLFPGTNDEEQL 218 G +PG +E Sbjct: 297 LGGSPYPGVQMDEDF 311 >4Y83-A nrPDB Length = 332 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 53/192 (27%), Positives = 84/192 (43%), Gaps = 13/192 (6%) Query: 16 GTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTE 75 G + VY + T +A K + +D + PS ++ + +HENI LY + Sbjct: 84 GAFGKVYLAQDIKTKKRMACKLIPVD--QFKPS----DVEIQACFRHENIAELYGAVLWG 137 Query: 76 NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLK 135 + L E + ++ R E+ V +L+GL F H K++H D+K Sbjct: 138 ETVHLFMEAGEGG--SVLEKLESCGPMREFEIIWVTK---HVLKGLDFLHSKKVIHHDIK 192 Query: 136 PQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSC 195 P N++ + L DFGL+ V T Y +P+V++ R +ST DI+S Sbjct: 193 PSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL-CRGHSTKADIYSL 250 Query: 196 GCILAEMITGKP 207 G L M TG P Sbjct: 251 GATLIHMQTGTP 262 >3VHK-A nrPDB Length = 368 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 35/117 (29%), Positives = 64/117 (54%), Gaps = 4/117 (3%) Query: 105 LELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLAR-AFGIPVN 163 L L + + +Q+ +G+ F K +HRDL +N+L++++ +K+ DFGLAR + P Sbjct: 197 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY 256 Query: 164 TFSSEV-VTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQL 218 + + L + AP+ + R Y+ D+WS G +L E+ + G +PG +E+ Sbjct: 257 VRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEF 312 >3ZBF-A nrPDB Length = 322 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/227 (25%), Positives = 107/227 (47%), Gaps = 21/227 (9%) Query: 13 LGNGTYATVYKG-----LNKTTG-VYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 LG+G + VY+G L +G + VA+K +K S + ++E LM + H NI+ Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNIL 100 Query: 67 RLYDVIHTENKLTLVFEFMDN-DLKKYM-DSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 + V ++ E M+ DL Y+ +R L L + + +G + Sbjct: 101 KQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYL 160 Query: 125 HENKILHRDLKPQNLLINKRGQ-----LKLGDFGLARAFGIPVNTFSSE----VVTLWYR 175 +HRDL +N L++ + +K+GDFGLAR I N + + ++ + + Sbjct: 161 ERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLAR--DIYKNDYYRKRGEGLLPVRWM 218 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 AP+ LM ++T D+WS G ++ E++T G +P ++ + L + Sbjct: 219 APESLMDG-IFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYV 264 >6GQK-A nrPDB Length = 328 Score = 58.9 bits (141), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/219 (26%), Positives = 95/219 (43%), Gaps = 21/219 (9%) Query: 13 LGNGTYATVY----KGLNKT-TGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHENIV 66 LG G + V +GL K+ + VA+K +K + + E+ ++ L HENIV Sbjct: 49 LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHENIV 108 Query: 67 RLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRG----------LELNLVKYFQW 115 L ++ E+ DL ++ + P L L + F + Sbjct: 109 NLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSY 168 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVTLW 173 Q+ +G+AF +HRDL +N+L+ K+ DFGLAR N + + + Sbjct: 169 QVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDKGNARLPVK 228 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPG 211 + AP+ + S Y+ D+WS G L E+ + G +PG Sbjct: 229 WMAPESIFNS-VYTFESDVWSYGIFLWELFSLGSSPYPG 266 >4F0G-A nrPDB Length = 287 Score = 58.5 bits (140), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 65/269 (24%), Positives = 113/269 (42%), Gaps = 33/269 (12%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA------IREISL 56 + ++ + +++G G + V+KG VA+K + L EG RE+ + Sbjct: 17 ADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFI 76 Query: 57 MKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 M L H NIV+LY ++H ++ + F + + +D L L L + Sbjct: 77 MSNLNHPNIVKLYGLMHNPPRMVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIE 136 Query: 117 LLQGLAFCHENKILHRDLKPQNLLI-----NKRGQLKLGDFGLARAFGIPVNTFSSEVVT 171 +Q I+HRDL+ N+ + N K+ DFGL++ V++ S + Sbjct: 137 YMQN----QNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ---SVHSVSGLLGN 189 Query: 172 LWYRAPDVLMG-SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNE 230 + AP+ + +Y+ D +S IL ++TG+ G DE I I E Sbjct: 190 FQWMAPETIGAEEESYTEKADTYSFAMILYTILTGE----GPFDEYSYGKIKFINMIREE 245 Query: 231 SLWPSVTKLPKYNPNIQQRPPRDLRQVLQ 259 L P++ + PPR LR V++ Sbjct: 246 GLRPTIP---------EDCPPR-LRNVIE 264 >5WNL-A nrPDB Length = 342 Score = 58.2 bits (139), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 101/214 (47%), Gaps = 17/214 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALK-EVKLDSEEGTPSTAIREISLMKELKH 62 + +F EK+G+G + VYK + ++A+K L ++ + E M+ K Sbjct: 19 AGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKF 78 Query: 63 ENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 I+ +Y + + + LV E+M+ L+K + S + P L +V + G+ Sbjct: 79 RYILPVYGI--CQEPVGLVMEYMETGSLEKLLASEPL---PWDLRFRIVH----ETAVGM 129 Query: 122 AF--CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN---TFSSEVVTLWYRA 176 F C +LH +LKP N+L++ +K+ DFGLA+ G+ + + T+ Y Sbjct: 130 NFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLP 189 Query: 177 PD-VLMGSRTYSTSIDIWSCGCILAEMITGKPLF 209 P+ + SR + T D++S ++ ++T K F Sbjct: 190 PERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPF 223 >4YFF-A nrPDB Length = 311 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 45/210 (21%), Positives = 94/210 (44%), Gaps = 10/210 (4%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 S+ + E +G+G++ VYKG + V + + RE+S++ +L H Sbjct: 42 SEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPC 101 Query: 65 IVRLYD-VIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 +++ ++ ++ +V +++ L + + R L+L + +G+ Sbjct: 102 VIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-----RILDLQSKLIIAVDVAKGME 156 Query: 123 FCHE--NKILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWYRAPDV 179 + H I+HRDL N+L+ + G + DFG +R + + + + L + AP+V Sbjct: 157 YLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEV 216 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLF 209 Y+ D++S L E++TG+ F Sbjct: 217 FTQCTRYTIKADVFSYALCLWEILTGEIPF 246 >2WTK-B nrPDB Length = 373 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 80/340 (23%), Positives = 126/340 (37%), Gaps = 62/340 (18%) Query: 7 FKQLEKLGNG--TYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLMKELKHE 63 ++ L +G G TV K TG YV ++ + L++ T ++ E+ + K H Sbjct: 11 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 70 Query: 64 NIVRLYDVIHTENKLTLVFEFM------DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 NIV +N+L +V FM D +MD G+ + Y + Sbjct: 71 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMD---------GMNELAIAYILQGV 121 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV------- 170 L+ L + H +HR +K ++LI+ G++ L GL + + VV Sbjct: 122 LKALDYIHHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYS 179 Query: 171 --TLWYRAPDVLMGS-RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQL--------K 219 L + +P+VL + + Y DI+S G E+ G F + L Sbjct: 180 VKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVP 239 Query: 220 LIFDIMGTPNESLWPS--------------VTKLPKYNPNIQQRPPRDLRQVLQPHTKEP 265 + D P E L S T P+ P+ P + PH Sbjct: 240 CLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPR--PSNGDSPSHPYHRTFSPH---- 293 Query: 266 LDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 F+ LQ NPD R SA L+H +F + AS Sbjct: 294 ----FHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRAS 329 >1FVR-A nrPDB Length = 327 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 54/224 (24%), Positives = 95/224 (42%), Gaps = 18/224 (8%) Query: 13 LGNGTYATVYKGLNKTTGVYV--ALKEVKLDSEEGTPSTAIREISLMKELKHE-NIVRLY 69 +G G + V K K G+ + A+K +K + + E+ ++ +L H NI+ L Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 92 Query: 70 DVIHTENKLTLVFEFM--DNDLKKYMDSRTV---------GNTPRGLELNLVKYFQWQLL 118 L L E+ N L SR + +T L + +F + Sbjct: 93 GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVA 152 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 +G+ + + + +HRDL +N+L+ + K+ DFGL+R + V + W Sbjct: 153 RGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIES 212 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMIT--GKPLFPGTNDEEQLKL 220 + Y+T+ D+WS G +L E+++ G P T E KL Sbjct: 213 --LNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKL 254 >5CEK-A nrPDB Length = 263 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 57/239 (23%), Positives = 94/239 (39%), Gaps = 43/239 (17%) Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H NI + +VI E K + FE D+ Y+ SR R E + F+ Q++ + Sbjct: 60 HSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRK-----RLREEEAARLFK-QIVSAV 113 Query: 122 AFCHENKILHRDLKPQNLLIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 A CH++ I+ DLK + + + +R QL+L + S + Y +P++ Sbjct: 114 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 173 Query: 180 LMGSRTYS-TSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 L + TYS + D+WS G +L ++ G+ F ++ I E + P Sbjct: 174 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARC 233 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 L + LL+ P RL+A + L HPWF Sbjct: 234 L----------------------------------IRSLLRREPSERLTAPEILLHPWF 258 >3G0E-A nrPDB Length = 336 Score = 57.0 bits (136), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 64/231 (27%), Positives = 97/231 (41%), Gaps = 43/231 (18%) Query: 13 LGNGTY-----ATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREI-SLMKELK----- 61 LG G + AT Y + + VA+K +K PS + E +LM ELK Sbjct: 54 LGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK-------PSAHLTEREALMSELKVLSYL 106 Query: 62 --HENIVRLYDVIHTENKLTLVFEF-----MDNDLKKYMDSRTVGNTPRGL--------E 106 H NIV L ++ E+ + N L++ DS T + + Sbjct: 107 GNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALD 166 Query: 107 LNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS 166 L + F +Q+ +G+AF +HRDL +N+L+ K+ DFGLAR + S Sbjct: 167 LEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLAR----DIKNDS 222 Query: 167 SEVVTLWYRAPDVLMGSRT-----YSTSIDIWSCGCILAEMIT-GKPLFPG 211 + VV R P M + Y+ D+WS G L E+ + G +PG Sbjct: 223 NYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPG 273 >6DC0-A nrPDB Length = 292 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/239 (23%), Positives = 94/239 (39%), Gaps = 43/239 (17%) Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H NI + +VI E K + FE D+ Y+ SR R E + F+ Q++ + Sbjct: 57 HSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRK-----RLREEEAARLFK-QIVSAV 110 Query: 122 AFCHENKILHRDLKPQNLLIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 A CH++ I+ DLK + + + +R QL+L + S + Y +P++ Sbjct: 111 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 170 Query: 180 LMGSRTYS-TSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 L + TYS + D+WS G +L ++ G+ F ++ I E + P Sbjct: 171 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARC 230 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 L + LL+ P RL+A + L HPWF Sbjct: 231 L----------------------------------IRSLLRREPSERLTAPEILLHPWF 255 >4M66-A nrPDB Length = 325 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 110/223 (49%), Gaps = 32/223 (14%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLMKE 59 + S + K+LE +G G + V++ ++T VA+K V S I E+ M Sbjct: 16 LVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN--------SKKISWEVKAMVN 67 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDND--LKKYMDSRTVGN-----TPRGLELNLVKY 112 L++EN++ L V TE+ L ++F+ + ++M++ ++ PR L L + Sbjct: 68 LRNENVLLLLGV--TED---LQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPL-LCRL 121 Query: 113 FQWQLLQGLAFCH--ENKILHRDLKPQNLLINKRGQLKLGDFGLA------RAFGIPVNT 164 Q +++ G+ + H + +LHRDLKP N+L++ KL DFGL+ ++ + Sbjct: 122 LQ-EVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSG 180 Query: 165 FSSEVVTLWYRAPDVLMG-SRTYSTSIDIWSCGCILAEMITGK 206 TL Y P++L + S + D++S G ++ ++ G+ Sbjct: 181 SRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >3SOC-A nrPDB Length = 322 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 79/302 (26%), Positives = 128/302 (42%), Gaps = 47/302 (15%) Query: 10 LEKLGNGTYATVYKG--LNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVR 67 LE G + V+K LN+ YVA+K + ++ + E+ + +KHENI++ Sbjct: 29 LEVKARGRFGCVWKAQLLNE----YVAVKIFPIQDKQSWQNE--YEVYSLPGMKHENILQ 82 Query: 68 LYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW-----QLLQGLA 122 I E + T V D DL G+ L+ N+V + + + +GLA Sbjct: 83 F---IGAEKRGTSV----DVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLA 135 Query: 123 FCHEN----------KILHRDLKPQNLLINKRGQLKLGDFGLARAF--GIPVNTFSSEVV 170 + HE+ I HRD+K +N+L+ + DFGLA F G +V Sbjct: 136 YLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVG 195 Query: 171 TLWYRAPDVLMGS----RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMG 226 T Y AP+VL G+ R ID+++ G +L E+ + G DE L +I Sbjct: 196 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEI-- 253 Query: 227 TPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL 286 PS+ + + + ++RP LR Q H + L + + + + RL Sbjct: 254 ----GQHPSLEDMQEVVVHKKKRPV--LRDYWQKHAGMAM---LCETIEECWDHDAEARL 304 Query: 287 SA 288 SA Sbjct: 305 SA 306 >6BFN-A nrPDB Length = 342 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 99/219 (45%), Gaps = 28/219 (12%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE---EGTPSTAIREISLMKELKHE 63 F + K+G G + VY+ + + T VY A+K +K +++ + + E+ + +H Sbjct: 24 FSEELKIGEGGFGCVYRAVMRNT-VY-AVKRLKENADLEWTAVKQSFLTEVEQLSRFRHP 81 Query: 64 NIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 NIV LV+ F+ N L+ + +T P L +L G A Sbjct: 82 NIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRL------DILLGTA 135 Query: 123 ----FCHENK--ILHRDLKPQNLLINKRGQLKLGDFGLAR--AFGIPVNTFSSEVV---- 170 F H++ ++H D+K N+L+++R KLGDFGLAR F + SS V Sbjct: 136 RAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQT 195 Query: 171 ---TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGK 206 TL Y P+ + + + D +S G ++ E + G+ Sbjct: 196 VRGTLAY-LPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >5USZ-A nrPDB Length = 289 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 98/215 (45%), Gaps = 26/215 (12%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVK-----LDSEEGTPSTAIRE-ISLMKELKHEN 64 E LG GT+ ++KG+ + G Y L E + LD S + E S+M +L H++ Sbjct: 14 ESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKH 73 Query: 65 IVRLYDVIHTENKLTLVFEF-----MDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 +V Y V ++ LV EF +D LKK ++ N LE+ QL Sbjct: 74 LVLNYGVCVCGDENILVQEFVKFGSLDTYLKK---NKNCINILWKLEV------AKQLAA 124 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGD--FGLARAFGIPVNTFSSEVVT--LWYR 175 + F EN ++H ++ +N+L+ + K G+ F GI + +++ + + Sbjct: 125 AMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWV 184 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITG--KPL 208 P+ + + + + D WS G L E+ +G KPL Sbjct: 185 PPECIENPKNLNLATDKWSFGTTLWEICSGGDKPL 219 >3Q4U-A nrPDB Length = 301 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 81/303 (26%), Positives = 125/303 (41%), Gaps = 49/303 (16%) Query: 10 LEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKE--LKHENIVR 67 LE +G G Y V++G G VA+K E+ + RE L L+HENI+ Sbjct: 13 LECVGKGRYGEVWRG--SWQGENVAVKIFSSRDEK----SWFRETELYNTVMLRHENILG 66 Query: 68 LY--DVI--HTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 D+ H+ +L L+ + + L Y+ T+ +T L + L + GLA Sbjct: 67 FIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL-DTVSCLRIVL------SIASGLA 119 Query: 123 FCH--------ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF----SSEVV 170 H + I HRDLK +N+L+ K GQ + D GLA N + V Sbjct: 120 HLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVG 179 Query: 171 TLWYRAPDVL-----MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIM 225 T Y AP+VL + +DIW+ G +L E+ + + E+ +D++ Sbjct: 180 TKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV--ARRMVSNGIVEDYKPPFYDVV 237 Query: 226 GTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMR 285 PN+ PS + K QQRP + +P +L + NP R Sbjct: 238 --PND---PSFEDMRKVVCVDQQRP-----NIPNRWFSDPTLTSLAKLMKECWYQNPSAR 287 Query: 286 LSA 288 L+A Sbjct: 288 LTA 290 >3LMG-A nrPDB Length = 344 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 52/211 (24%), Positives = 102/211 (48%), Gaps = 22/211 (10%) Query: 5 SQFKQLEKLGNGTYATVYKGL----NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 ++ ++L+ LG+G + TV+KG+ ++ + V +K ++ S + + + L Sbjct: 31 TELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSL 90 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW--QLL 118 H +IVRL + + L LV +++ L +D G +L L W Q+ Sbjct: 91 DHAHIVRLLGLC-PGSSLQLVTQYLP--LGSLLDHVRQHRGALGPQLLL----NWGVQIA 143 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT---FSSEVVT--LW 173 +G+ + E+ ++HR+L +N+L+ Q+++ DFG+A +P + SE T W Sbjct: 144 KGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADL--LPPDDKQLLYSEAKTPIKW 201 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMIT 204 + G T+ + D+WS G + E++T Sbjct: 202 MALESIHFGKYTHQS--DVWSYGVTVWELMT 230 >4NFN-A nrPDB Length = 309 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 54/227 (23%), Positives = 100/227 (44%), Gaps = 19/227 (8%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HEN 64 ++K L+K+G G + +Y+ ++ T VALK ++S + E++++K+L+ ++ Sbjct: 22 RWKVLKKIGGGGFGEIYEAMDLLTRENVALK---VESAQQPKQVLKMEVAVLKKLQGKDH 78 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 + R E +V + +L S+ G L L K Q+L+ + Sbjct: 79 VCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGK----QILESIEAI 134 Query: 125 HENKILHRDLKPQNLLINK----RGQLKLGDFGLARAFG------IPVNTFSSEVVTLWY 174 H LHRD+KP N + + + + DFGLAR + P + T+ Y Sbjct: 135 HSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRY 194 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLI 221 + + +R D+WS +L E G+ + D+EQ+ +I Sbjct: 195 ASVNA-HKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMI 240 >3MDY-A nrPDB Length = 337 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 81/283 (28%), Positives = 124/283 (43%), Gaps = 46/283 (16%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGT--PSTAIREISLMKELK 61 + Q + ++++G G Y V+ G K G VA+K V +EE + T I + LM+ Sbjct: 36 AKQIQMVKQIGKGRYGEVWMG--KWRGEKVAVK-VFFTTEEASWFRETEIYQTVLMR--- 89 Query: 62 HENIVRLY--DVIHTEN--KLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 HENI+ D+ T + +L L+ ++ +N L Y+ S T L+ + + Sbjct: 90 HENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT-------LDAKSMLKLAYS 142 Query: 117 LLQGLAFCHEN--------KILHRDLKPQNLLINKRGQLKLGDFGLARAF-------GIP 161 + GL H I HRDLK +N+L+ K G + D GLA F IP Sbjct: 143 SVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIP 202 Query: 162 VNTFSSEVVTLWYRAPDVLMGS--RTYSTS---IDIWSCGCILAEMITGKPLFPGTNDEE 216 NT V T Y P+VL S R + S D++S G IL E + + + G +E Sbjct: 203 PNT---RVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWE-VARRCVSGGIVEEY 258 Query: 217 QLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRD--LRQV 257 QL + P+ + + K P+ R D LRQ+ Sbjct: 259 QLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQM 301 >4BTK-A nrPDB Length = 337 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 54/227 (23%), Positives = 100/227 (44%), Gaps = 19/227 (8%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HEN 64 ++K L+K+G G + +Y+ ++ T VALK ++S + E++++K+L+ ++ Sbjct: 57 RWKVLKKIGGGGFGEIYEAMDLLTRENVALK---VESAQQPKQVLKMEVAVLKKLQGKDH 113 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 + R E +V + +L S+ G L L K Q+L+ + Sbjct: 114 VCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGK----QILESIEAI 169 Query: 125 HENKILHRDLKPQNLLINK----RGQLKLGDFGLARAFG------IPVNTFSSEVVTLWY 174 H LHRD+KP N + + + + DFGLAR + P + T+ Y Sbjct: 170 HSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRY 229 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLI 221 + + +R D+WS +L E G+ + D+EQ+ +I Sbjct: 230 ASVNA-HKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMI 275 >3G2F-A nrPDB Length = 336 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 65/235 (27%), Positives = 99/235 (42%), Gaps = 41/235 (17%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 K LE +G G Y VYKG V V + + + I + LM+ H+NI Sbjct: 15 LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFA-NRQNFINEKNIYRVPLME---HDNIA 70 Query: 67 RLY---DVIHTENKLT--LVFEFMDN-DLKKYMD---------SRTVGNTPRGLELNLVK 111 R + + + ++ LV E+ N L KY+ R + RGL Sbjct: 71 RFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGL-----A 125 Query: 112 YFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF--------GIPVN 163 Y +L +G + + I HRDL +N+L+ G + DFGL+ G N Sbjct: 126 YLHTELPRGDHY--KPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDN 183 Query: 164 TFSSEVVTLWYRAPDVLMGS------RTYSTSIDIWSCGCILAEM-ITGKPLFPG 211 SEV T+ Y AP+VL G+ + +D+++ G I E+ + LFPG Sbjct: 184 AAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPG 238 >2VD5-A nrPDB Length = 412 Score = 54.3 bits (129), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 100/228 (43%), Gaps = 20/228 (8%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDS-EEGTPSTAIREISLMKELKHEN 64 F+ L+ +G G ++ V K TG A+K + K D + G S E ++ Sbjct: 63 FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRW 122 Query: 65 IVRLYDVIHTENKLTLVFEF-MDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 I +L+ EN L LV E+ + DL + S+ P + +++ +++ + Sbjct: 123 ITQLHFAFQDENYLYLVMEYYVGGDLLTLL-SKFGERIPA----EMARFYLAEIVMAIDS 177 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLA---RAFGIPVNTFSSEVVTLWYRAPDVL 180 H +HRD+KP N+L+++ G ++L DFG RA G + + V T Y +P++L Sbjct: 178 VHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVA--VGTPDYLSPEIL 235 Query: 181 MGSRTYST------SIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLI 221 D W+ G EM G+ P + + E K++ Sbjct: 236 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV 283 >4L00-A nrPDB Length = 304 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 98/210 (46%), Gaps = 24/210 (11%) Query: 9 QLEKLGNGTYATVY----------KGLNKTTGVYVALKEVKLDSEEGTPSTAIREI-SLM 57 Q E LG GT +Y +G ++ + V LK LD S A E S+M Sbjct: 29 QGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILK--VLDPSHRDISLAFFEAASMM 86 Query: 58 KELKHENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRT-VGNTPRGLELNLVKYFQW 115 +++ H++IV LY V + + +V EF++ L +M ++ V TP ++ Sbjct: 87 RQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAK------ 140 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRG-QLKLGDFGLARAFGIPVNTFSSE--VVTL 172 QL L++ + ++H ++ +NLL+ + G + G F GIP+ S + + + Sbjct: 141 QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERI 200 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEM 202 + AP+ + S+ S + D WS G L E+ Sbjct: 201 PWIAPECVEDSKNLSVAADKWSFGTTLWEI 230 >2H34-A nrPDB Length = 309 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 92/204 (45%), Gaps = 13/204 (6%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVK--LDSEEGTPSTAIREISLMKELKHENIVRLYD 70 +G G VY+ + VALK + L S+ + RE L+ ++V ++D Sbjct: 42 VGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHD 101 Query: 71 VIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 + +L + ++ DL + + PR + + Q+ L H Sbjct: 102 FGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAI------VRQIGSALDAAHAAGA 155 Query: 130 LHRDLKPQNLLINKRGQLKLGDFGLARA-FGIPVNTFSSEVVTLWYRAPDVLMGSRTYST 188 HRD+KP+N+L++ L DFG+A A + + V TL+Y AP+ S +++T Sbjct: 156 THRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERF--SESHAT 213 Query: 189 -SIDIWSCGCILAEMITGKPLFPG 211 DI++ C+L E +TG P + G Sbjct: 214 YRADIYALTCVLYECLTGSPPYQG 237 >3TKU-A nrPDB Length = 433 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 50/192 (26%), Positives = 86/192 (44%), Gaps = 15/192 (7%) Query: 65 IVRLYDVIHTENKLTLVFEF-MDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 I L+ EN L LV ++ + DL + S+ P ++ +++ +++ + Sbjct: 152 ITALHYAFQDENHLYLVMDYYVGGDLLTLL-SKFEDKLPE----DMARFYIGEMVLAIDS 206 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-TLWYRAPDVLM- 181 H+ +HRD+KP N+L++ G ++L DFG SS V T Y +P++L Sbjct: 207 IHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQA 266 Query: 182 ---GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS-VT 237 G Y D WS G + EM+ G+ F E ++ IM +PS VT Sbjct: 267 MEDGMGKYGPECDWWSLGVCMYEMLYGETPFYA---ESLVETYGKIMNHEERFQFPSHVT 323 Query: 238 KLPKYNPNIQQR 249 + + ++ QR Sbjct: 324 DVSEEAKDLIQR 335 >5VDK-A nrPDB Length = 297 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 38/145 (26%), Positives = 71/145 (48%), Gaps = 7/145 (4%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTG-VYVALKEVKLDSEEGTPSTAIREISLMKELKHE- 63 +F ++EK+G G + TVYK + + G VY + +K +E ++A+ E+ L H Sbjct: 16 EFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHP 75 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRG--LELNLVKYFQWQLLQGL 121 ++VR Y ++ + + E+ + + + NT G E +K Q+ GL Sbjct: 76 HVVRYYSSWAEDDHMIIQNEYCNGG---SLQAAISENTKSGNHFEEPKLKDILLQISLGL 132 Query: 122 AFCHENKILHRDLKPQNLLINKRGQ 146 + H + ++H D+KP N+ I + Q Sbjct: 133 NYIHNSSMVHLDIKPSNIFICHKMQ 157 >2Y4I-B nrPDB Length = 319 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 40/161 (24%), Positives = 77/161 (47%), Gaps = 18/161 (11%) Query: 7 FKQLEK---LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 F+QLE +G G + VY G V + L +++ D+E+ + RE+ ++ +HE Sbjct: 32 FEQLEIGELIGKGRFGQVYHG-RWHGEVAIRLIDIERDNEDQLKAFK-REVMAYRQTRHE 89 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRG----LELNLVKYFQWQLLQ 119 N+V + L ++ RT+ + R L++N + ++++ Sbjct: 90 NVVLFMGACMSPPHLAIITSLCKG--------RTLYSVVRDAKIVLDVNKTRQIAQEIVK 141 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGI 160 G+ + H ILH+DLK +N+ + G++ + DFGL G+ Sbjct: 142 GMGYLHAKGILHKDLKSKNVFYDN-GKVVITDFGLFSISGV 181 >4AW2-A nrPDB Length = 437 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 92/213 (43%), Gaps = 17/213 (7%) Query: 7 FKQLEKLGNGTYATV----YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 F+ L+ +G G + V K +K + + K L E R++ + + K Sbjct: 76 FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKW 135 Query: 63 ENIVRLYDVIHTENKLTLVFEF-MDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 I L+ +N L LV ++ + DL + S+ P + +++ +++ + Sbjct: 136 --ITTLHYAFQDDNNLYLVMDYYVGGDLLTLL-SKFEDRLPE----EMARFYLAEMVIAI 188 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-TLWYRAPDVL 180 H+ +HRD+KP N+L++ G ++L DFG SS V T Y +P++L Sbjct: 189 DSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEIL 248 Query: 181 M----GSRTYSTSIDIWSCGCILAEMITGKPLF 209 G Y D WS G + EM+ G+ F Sbjct: 249 QAMEGGKGRYGPECDWWSLGVCMYEMLYGETPF 281 >4RT7-A nrPDB Length = 415 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 33/105 (31%), Positives = 53/105 (50%), Gaps = 10/105 (9%) Query: 113 FQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTL 172 F +Q+ +G+ F +HRDL +N+L+ +K+ DFGLAR + + S+ VV Sbjct: 248 FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLAR----DIMSDSNYVVRG 303 Query: 173 WYRAPDVLMGSRT-----YSTSIDIWSCGCILAEMIT-GKPLFPG 211 R P M + Y+ D+WS G +L E+ + G +PG Sbjct: 304 NARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPG 348 Score = 36.6 bits (83), Expect = 0.016, Method: Compositional matrix adjust. Identities = 29/92 (31%), Positives = 47/92 (51%), Gaps = 9/92 (9%) Query: 13 LGNGTY-----ATVYKGLNKT-TGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHENI 65 LG+G + AT Y G++KT + VA+K +K ++ + E+ +M +L HENI Sbjct: 73 LGSGAFGKVMNATAY-GISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENI 131 Query: 66 VRLYDVIHTENKLTLVFEFMD-NDLKKYMDSR 96 V L + L+FE+ DL Y+ S+ Sbjct: 132 VNLLGACTLSGPIYLIFEYCCYGDLLNYLRSK 163 >1PY5-A nrPDB Length = 326 Score = 49.7 bits (117), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 73/262 (27%), Positives = 108/262 (41%), Gaps = 36/262 (13%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E +G G + V++G K G VA+K E A EI L+HENI+ Sbjct: 35 ESIGKGRFGEVWRG--KWRGEEVAVKIFSSREERSWFREA--EIYQTVMLRHENILGFIA 90 Query: 71 VIHTEN----KLTLVFEFMDN-DLKKYMDSRTVGNTPRGL-ELNLVKYFQWQLLQGLAFC 124 + +N +L LV ++ ++ L Y++ TV T G+ +L L GLA Sbjct: 91 ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTV--TVEGMIKLAL------STASGLAHL 142 Query: 125 H--------ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF----SSEVVTL 172 H + I HRDLK +N+L+ K G + D GLA +T + V T Sbjct: 143 HMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTK 202 Query: 173 WYRAPDVLMGSRTYS-----TSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGT 227 Y AP+VL S DI++ G + E I + G +++ QL + Sbjct: 203 RYMAPEVLDDSINMKHFESFKRADIYAMGLVFWE-IARRCSIGGIHEDYQLPYYDLVPSD 261 Query: 228 PNESLWPSVTKLPKYNPNIQQR 249 P+ V K PNI R Sbjct: 262 PSVEEMRKVVCEQKLRPNIPNR 283 >5VC6-A nrPDB Length = 289 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 34/152 (22%), Positives = 73/152 (48%), Gaps = 23/152 (15%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD-SEEGTPSTAIREISLMKEL-K 61 +++F +LEK+G+G + +V+K + + G A+K K + A+RE+ L + Sbjct: 10 TTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQ 69 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELN--LVKYFQ----- 114 H ++VR + ++ + + E+ + G+ + N ++ YF+ Sbjct: 70 HSHVVRYFSAWAEDDHMLIQNEYCNG-----------GSLADAISENYRIMSYFKEAELK 118 Query: 115 ---WQLLQGLAFCHENKILHRDLKPQNLLINK 143 Q+ +GL + H ++H D+KP N+ I++ Sbjct: 119 DLLLQVGRGLRYIHSMSLVHMDIKPSNIFISR 150 >4JRN-A nrPDB Length = 372 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 60/223 (26%), Positives = 92/223 (41%), Gaps = 43/223 (19%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGT---------PSTAIREISLMKELKH- 62 LG+G +ATVY+ + T +A+K V + +E T S+ R SL K K Sbjct: 76 LGSGGFATVYEATDVETNEELAVK-VFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 63 ENIVRLY---DVI-------HTENKLTLVFEFMDN----------DLKKYMD----SRTV 98 + R DV+ TE + L ++ N D+ K + +V Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASV 194 Query: 99 GNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF 158 + GL + + Y Q ++ +A I+H D+KP N L+ K G+L LGDFG R Sbjct: 195 NKSEFGLVVRM--YLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRIN 252 Query: 159 GIPVNTFSSEVVTLWYRAPDVLMGSR--TYSTSIDIWSCGCIL 199 N+ + T Y P+ + TY+ D W G L Sbjct: 253 ----NSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITL 291 >5M07-A nrPDB Length = 276 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 30/121 (24%), Positives = 57/121 (47%), Gaps = 9/121 (7%) Query: 52 REISLMKELKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLV 110 RE + L H +I+ ++D + +L + +++D D ++M R P G L +V Sbjct: 79 RETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIV 138 Query: 111 KYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRG----QLKLGDFGLARAFGIPVNTFS 166 + L + H+ +LHRD+ P N+++ + ++ L DFG+A P S Sbjct: 139 T----AVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQPSYPAPELS 194 Query: 167 S 167 + Sbjct: 195 A 195 >4Y12-A nrPDB Length = 375 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 43/202 (21%), Positives = 102/202 (50%), Gaps = 14/202 (6%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTT-GVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 + Q++ + +G +Y L++ G V LK + + + A+ E + E+ H Sbjct: 118 AGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVH 177 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW--QLLQG 120 +IV++++ + ++ ++ + +Y+ +++ + +G +L + + + ++L Sbjct: 178 PSIVQIFNFVEHTDRHGDPVGYI---VMEYVGGQSLKRS-KGQKLPVAEAIAYLLEILPA 233 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 L++ H +++ DLKP+N+++ + QLKL D G +N+F T ++AP+++ Sbjct: 234 LSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSR----INSFGYLYGTPGFQAPEIV 288 Query: 181 MGSRTYSTSIDIWSCGCILAEM 202 T +T DI++ G LA + Sbjct: 289 RTGPTVAT--DIYTVGRTLAAL 308 >4M69-B nrPDB Length = 283 Score = 47.4 bits (111), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 47/227 (20%), Positives = 101/227 (44%), Gaps = 25/227 (11%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-----EISLMKELKHENIV 66 KL +T+Y+G + V + + ++ + +R EI MK+ NI+ Sbjct: 16 KLKTSKMSTIYRGEYHRSPVTIKV----FNNPQAESVGIVRFTFNDEIKTMKKFDSPNIL 71 Query: 67 RLYDVIHTEN----KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 R++ + + + ++V E+ + L++ +D + L +++ + +GL Sbjct: 72 RIFGICIDQTVKPPEFSIVMEYCELGTLRELLDRE------KDLTMSVRSLLVLRAARGL 125 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFG----IPVNTFSSEVVTLWYRAP 177 H ++ LHR++ + L+ Q+KL F L++ +T + + Y +P Sbjct: 126 YRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSP 185 Query: 178 DVLMGSRT-YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFD 223 + L Y +I+S G +L E+ TGK F G + ++ +L+ + Sbjct: 186 ERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAE 232 >2PZI-A nrPDB Length = 681 Score = 47.4 bits (111), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 44/207 (21%), Positives = 103/207 (49%), Gaps = 14/207 (6%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTT-GVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 + Q++ + +G +Y L++ G V LK + + + A+ E + E+ H Sbjct: 79 AGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVH 138 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW--QLLQG 120 +IV++++ + ++ ++ + +Y+ +++ + +G +L + + + ++L Sbjct: 139 PSIVQIFNFVEHTDRHGDPVGYI---VMEYVGGQSLKRS-KGQKLPVAEAIAYLLEILPA 194 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 L++ H +++ DLKP+N+++ + QLKL D G +N+F T ++AP+++ Sbjct: 195 LSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSR----INSFGYLYGTPGFQAPEIV 249 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKP 207 T +T DI++ G LA + P Sbjct: 250 RTGPTVAT--DIYTVGRTLAALTLDLP 274 >4BTF-A nrPDB Length = 469 Score = 47.0 bits (110), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 47/227 (20%), Positives = 101/227 (44%), Gaps = 25/227 (11%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-----EISLMKELKHENIV 66 KL +T+Y+G + V + + ++ + +R EI MK+ NI+ Sbjct: 202 KLKTSKMSTIYRGEYHRSPVTIKV----FNNPQAESVGIVRFTFNDEIKTMKKFDSPNIL 257 Query: 67 RLYDVIHTEN----KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 R++ + + + ++V E+ + L++ +D + L +++ + +GL Sbjct: 258 RIFGICIDQTVKPPEFSIVMEYCELGTLRELLDRE------KDLTMSVRSLLVLRAARGL 311 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFG----IPVNTFSSEVVTLWYRAP 177 H ++ LHR++ + L+ Q+KL F L++ +T + + Y +P Sbjct: 312 YRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSP 371 Query: 178 DVLMGSRT-YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFD 223 + L Y +I+S G +L E+ TGK F G + ++ +L+ + Sbjct: 372 ERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAE 418 >3SV0-A nrPDB Length = 483 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 60/245 (24%), Positives = 104/245 (42%), Gaps = 28/245 (11%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 ++F+ K+G+G++ +Y G N T VA +KL++ + + E + + L+ Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVA---IKLENVKTKHPQLLYESKIYRILQGGT 63 Query: 65 I---VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 VR + V N LV + + L+ + R L L V Q++ + Sbjct: 64 GIPNVRWFGVEGDYN--VLVMDLLGPSLEDLFNF-----CSRKLSLKTVLMLADQMINRV 116 Query: 122 AFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFG-------IPVNTFSSEVVT 171 F H LHRD+KP N L+ + Q+ + DFGLA+ + IP + T Sbjct: 117 EFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGT 176 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITG----KPLFPGTNDEEQLKLIFDIMGT 227 Y + + +G S D+ S G +L + G + L GT ++ K+ + T Sbjct: 177 ARYASVNTHLGIEQ-SRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVAT 235 Query: 228 PNESL 232 E+L Sbjct: 236 SIEAL 240 >4LQP-A nrPDB Length = 508 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 39/155 (25%), Positives = 69/155 (44%), Gaps = 9/155 (5%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE---EGTPSTAIREISLMKELKHE 63 F ++ +G G + V K TG A+K + L SE + + E ++ Sbjct: 104 FHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTL-LKSEMYKKDQLAHVKAERDVLAGSDSP 162 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 +V LY L L+ EF+ D T+ + ++ +++ + + + Sbjct: 163 WVVSLYYSFQDAQYLYLIMEFLPGG-----DLMTMLIRWQLFTEDVTRFYMAECILAIET 217 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF 158 H+ +HR +KP N+LI+ RG +KL DFGL+ F Sbjct: 218 IHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGF 252 >3M42-A nrPDB Length = 299 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 66/295 (22%), Positives = 104/295 (35%), Gaps = 66/295 (22%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISL-MKELKHENIVRLYDV 71 LG G V + NK T ALK + + P A RE+ L + + +IVR+ DV Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKML-----QDCPK-ARREVELHWRASQCPHIVRIVDV 79 Query: 72 IHT----ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 L +V E +D + SR + + + + + H Sbjct: 80 YENLYAGRKCLLIVMECLDGG---ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 136 Query: 128 KILHRDLKPQNLLINKR---GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 I HRD+KP+NLL + LKL DFG A+ Sbjct: 137 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-----------------------TTGE 173 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 Y S D+WS G I+ ++ G P F N L +P Sbjct: 174 KYDKSCDMWSLGVIMYILLCGYPPF-----------------YSNHGL--------AISP 208 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 ++ R + P E + + + LL+ P R++ + ++HPW + Sbjct: 209 GMKTRIRMGQYEFPNPEWSE-VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 262 >2C47-A nrPDB Length = 313 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 42/166 (25%), Positives = 71/166 (42%), Gaps = 14/166 (8%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 S F+ +K+G G + + G N T YVA+K + S P + E K+L Sbjct: 1 SMGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSR--APQLHL-EYRFYKQLS 57 Query: 62 H-ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 E + ++Y +V E + L+ D R L V QL+ Sbjct: 58 ATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDL-----CDRTFTLKTVLMIAIQLITR 112 Query: 121 LAFCHENKILHRDLKPQNLLINKRG-----QLKLGDFGLARAFGIP 161 + + H +++RD+KP+N L+ + G + + DFGLA+ + P Sbjct: 113 MEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDP 158 >2CMW-A nrPDB Length = 310 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/158 (27%), Positives = 69/158 (43%), Gaps = 15/158 (9%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH--ENIVRL 68 +K+G G + + G N T YVA+K + S P + E K+L E + ++ Sbjct: 6 KKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSR--APQLHL-EYRFYKQLGSAGEGLPQV 62 Query: 69 YDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 Y +V E + L+ D R L V QLL + + H Sbjct: 63 YYFGPCGKYNAMVLELLGPSLEDLFDL-----CDRTFTLKTVLMIAIQLLSRMEYVHSKN 117 Query: 129 ILHRDLKPQNLLINKRGQLK-----LGDFGLARAFGIP 161 +++RD+KP+N LI ++G K + DFGLA+ + P Sbjct: 118 LIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDP 155 >5FQD-C nrPDB Length = 341 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 43/164 (26%), Positives = 73/164 (44%), Gaps = 22/164 (13%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-- 61 ++K + K+G+G++ +Y +N T G VA VKL+S++ + E L K L+ Sbjct: 18 GGKYKLVRKIGSGSFGDIYLAINITNGEEVA---VKLESQKARHPQLLYESKLYKILQGG 74 Query: 62 ----HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 H +R Y N LV + + L+ + R + V Q+ Sbjct: 75 VGIPH---IRWYGQEKDYN--VLVMDLLGPSLEDLFNF-----CSRRFTMKTVLMLADQM 124 Query: 118 LQGLAFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAF 158 + + + H +HRD+KP N L+ +L L DFGLA+ + Sbjct: 125 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY 168 >5L2Q-C nrPDB Length = 320 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 27/87 (31%), Positives = 46/87 (52%), Gaps = 3/87 (3%) Query: 125 HENKILHRDLKPQNLLINKRG-QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 H+ I+HRDLK N+++NKR ++ + +F L + + + + Y +PDVL G Sbjct: 170 HQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGR 229 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFP 210 D+W+ G +L M+ G+ FP Sbjct: 230 PYRGKPSDMWALGVVLFTMLYGQ--FP 254 >4L68-A nrPDB Length = 340 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 49/170 (28%), Positives = 81/170 (47%), Gaps = 32/170 (18%) Query: 53 EISLMKELKHENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVK 111 E++ + EL+H N+ L E + LV+++M N L +DS RG EL+ Sbjct: 85 EMNQLWELRHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSN------RG-ELDWST 137 Query: 112 YFQWQL--LQGLAFCHEN---KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS 166 F+ L +GLA+ H ILH+++ +LI++ ++ D GLAR +P + Sbjct: 138 RFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLM-VPSDNNE 196 Query: 167 SEVVT-----LWYRAPDVLMGSRTYSTSI------DIWSCGCILAEMITG 205 S +T Y AP+ YST++ D++ G +L E+ TG Sbjct: 197 SSFMTGDLGEFGYVAPE-------YSTTMLASLKGDVYGLGVVLLELATG 239 >5AR8-A nrPDB Length = 326 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 53/229 (23%), Positives = 97/229 (42%), Gaps = 23/229 (10%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVK-----LDSEEGTPSTAIREISLMKEL 60 + L L G TV + V VA+K + LDSE +RE ++ + Sbjct: 33 KLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER---KDVLREAEILHKA 89 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRT-VGNTPRGLELNLVKYFQWQLL 118 + I+ + + + L +V E+M N L + + +T + L ++ ++ Sbjct: 90 RFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILH----EIA 145 Query: 119 QGLAFCHENK--ILHRDLKPQNLLINKRGQLKLGDFGLAR-----AFGIPVNTFSSEVVT 171 G+ + H +LH DLK QN+L++ +K+ DFGL++ + + E T Sbjct: 146 LGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGT 205 Query: 172 LWYRAPDVLMGSRTYSTSI--DIWSCGCILAEMITGKPLFPGTNDEEQL 218 + Y P+ + SI DI+S I E+++ K F + Q+ Sbjct: 206 IIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQI 254 >4MWI-A nrPDB Length = 294 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 23/218 (10%) Query: 19 ATVYKGLNKTTGVYV-ALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTEN- 76 +T+YKG V + K+++ S T +EI MK+ + NI+R++ + E Sbjct: 38 STLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETV 97 Query: 77 ---KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQL--LQGLAFCHENKI- 129 + ++V E+ + L++ +D R +L L K L +GL H ++ Sbjct: 98 TPPQFSIVMEYCELGTLRELLD--------REKDLTLGKRMVLVLGAARGLYRLHHSEAP 149 Query: 130 -LHRDLKPQNLLINKRGQLKLGDFGLARA-FGIPVNTF---SSEVVTLWYRAPDVLMGS- 183 LH ++ N L+ + Q+KL F L + + + T + V + Y +P L Sbjct: 150 ELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVF 209 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLI 221 Y +I+S G +L E+ TG F G N E+ KL+ Sbjct: 210 YQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLV 247 >4IX6-A nrPDB Length = 350 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 47/167 (28%), Positives = 71/167 (42%), Gaps = 26/167 (15%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLD---SEE--------------GTPSTAIREIS 55 LG+G + TV++G+ K V LK K D +EE T R + Sbjct: 28 LGSGNFGTVFRGVFKGD-QDVVLKNAKADVMAAEELLECEMDVNYHVHANAKGTCARFMG 86 Query: 56 LMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDS-----RTVGNTPRGLELNLV 110 + EL ++ +Y+ TE + +N ++ M T EL + Sbjct: 87 CI-ELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATELGVT 145 Query: 111 KYFQWQLLQGLAFCHENKILHRDLKPQNLLINKR--GQLKLGDFGLA 155 K +LL LA HE ++HRD+KP NL+ ++ G LKL D G A Sbjct: 146 KKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAA 192 >2CHL-A nrPDB Length = 351 Score = 43.9 bits (102), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 59/253 (23%), Positives = 101/253 (39%), Gaps = 26/253 (10%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHENI 65 F+ +K+G G + + G N T YVA+K + S P + E K+L + I Sbjct: 32 FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSR--APQLHL-EYRFYKQLGSGDGI 88 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 ++Y +V E + L+ D R L V QL+ + + H Sbjct: 89 PQVYYFGPCGKYNAMVLELLGPSLEDLFDL-----CDRTFSLKTVLMIAIQLISRMEYVH 143 Query: 126 ENKILHRDLKPQNLLINKRGQ-----LKLGDFGLARAF-------GIPVNTFSSEVVTLW 173 +++RD+KP+N LI + G + + DF LA+ + IP S T Sbjct: 144 SKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTAR 203 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDE---EQLKLIFDI-MGTPN 229 Y + + +G S D+ + G + + G + G + E+ + I D TP Sbjct: 204 YMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPI 262 Query: 230 ESLWPSVTKLPKY 242 E L + ++ Y Sbjct: 263 EVLCENFPEMATY 275 >5E8V-A nrPDB Length = 316 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 90/217 (41%), Gaps = 32/217 (14%) Query: 13 LGNGTYATVYKG-LNKTTGVYVALKEVKL-DSEEGTPSTAIREISLMKELKHENIVRLYD 70 +G G +A VYK L + T VK+ EE ++I LKHENI++ Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLT 76 Query: 71 VIHTENKLT----LVFEF-MDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 + +L L+ F +L++Y+ T + ++ L +G+A H Sbjct: 77 AEERKTELGKQYWLITAFHAKGNLQEYL-------TRHVISWEDLRKLGSSLARGIAHLH 129 Query: 126 ENK---------ILHRDLKPQNLLINKRGQLKLGDFGLARAFG--IPVNTF--SSEVVTL 172 + I+HRDLK N+L+ L DFGL+ + V+ S +V T Sbjct: 130 SDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 189 Query: 173 WYRAPDVLMGSRTYST-----SIDIWSCGCILAEMIT 204 Y AP+VL + D++S +L EM + Sbjct: 190 RYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTS 226 >3MY0-A nrPDB Length = 305 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 76/309 (24%), Positives = 125/309 (40%), Gaps = 49/309 (15%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 + Q +E +G G Y V++GL V V + + D + T I L L+H+ Sbjct: 7 ARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSR-DEQSWFRETEIYNTVL---LRHD 62 Query: 64 NIVRLY--DVI--HTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 NI+ D+ ++ +L L+ + ++ L ++ +T LE +L Sbjct: 63 NILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQT-------LEPHLALRLAVSAA 115 Query: 119 QGLAFCH--------ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF----S 166 GLA H + I HRD K +N+L+ Q + D GLA + + Sbjct: 116 CGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNN 175 Query: 167 SEVVTLWYRAPDVL---MGSRTYSTS--IDIWSCGCILAEMITGKPLFPGTNDEEQLKLI 221 V T Y AP+VL + + + + DIW+ G +L E I + + G E+ Sbjct: 176 PRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWE-IARRTIVNGIV-EDYRPPF 233 Query: 222 FDIMGTPNESLWPSVTKLPKYNPNIQQRP--PRDLRQVLQPHTKEPLDGNLMDFLHGLLQ 279 +D++ PN+ PS + K QQ P P L +P+ L + Sbjct: 234 YDVV--PND---PSFEDMKKVVCVDQQTPTIPNRL-------AADPVLSGLAQMMRECWY 281 Query: 280 LNPDMRLSA 288 NP RL+A Sbjct: 282 PNPSARLTA 290 >5X18-A nrPDB Length = 295 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 38/161 (23%), Positives = 68/161 (42%), Gaps = 12/161 (7%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 +K +K+G G++ +++G N GV VA+K +E + ++ NI Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTP--NI 65 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 Y LV + + L+ D R + V Q++ + H Sbjct: 66 PYAYYFGQEGLHNILVIDLLGPSLEDLFDW-----CGRKFSVKTVVQVAVQMITLIEDLH 120 Query: 126 ENKILHRDLKPQNLLINKRGQ-----LKLGDFGLARAFGIP 161 + +++RD+KP N LI + GQ + L DFG+A+ + P Sbjct: 121 AHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDP 161 >4WOV-A nrPDB Length = 317 Score = 42.4 bits (98), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 49/230 (21%), Positives = 97/230 (42%), Gaps = 41/230 (17%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE--------GTPSTAIREI--- 54 + QL LG GT VY+G + G +E K+D E+ G + ++ Sbjct: 36 EITQLSHLGQGTRTNVYEGRLRVEGSGDP-EEGKMDDEDPLVPGRDRGQELRVVLKVLDP 94 Query: 55 -------------SLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNT 101 SLM ++ H ++ ++ V + +V E++++ R G+ Sbjct: 95 SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHV 154 Query: 102 PRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQ-------LKLGDFGL 154 P ++ + + QL L++ ++H ++ +N+L+ + G +KL D G+ Sbjct: 155 PMAWKMVVAQ----QLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGV 210 Query: 155 ARAFGIPVNTFSSEVVTLWYRAPDVL-MGSRTYSTSIDIWSCGCILAEMI 203 G+ + V + + AP+ L G+ + ST++D W G L E+ Sbjct: 211 ----GLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEIC 256 >5C01-A nrPDB Length = 342 Score = 42.4 bits (98), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 49/230 (21%), Positives = 97/230 (42%), Gaps = 41/230 (17%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE--------GTPSTAIREI--- 54 + QL LG GT VY+G + G +E K+D E+ G + ++ Sbjct: 59 EITQLSHLGQGTRTNVYEGRLRVEGSGDP-EEGKMDDEDPLVPGRDRGQELRVVLKVLDP 117 Query: 55 -------------SLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNT 101 SLM ++ H ++ ++ V + +V E++++ R G+ Sbjct: 118 SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHV 177 Query: 102 PRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQ-------LKLGDFGL 154 P ++ + + QL L++ ++H ++ +N+L+ + G +KL D G+ Sbjct: 178 PMAWKMVVAQ----QLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGV 233 Query: 155 ARAFGIPVNTFSSEVVTLWYRAPDVL-MGSRTYSTSIDIWSCGCILAEMI 203 G+ + V + + AP+ L G+ + ST++D W G L E+ Sbjct: 234 ----GLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEIC 279 >4NT4-A nrPDB Length = 312 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 49/215 (22%), Positives = 86/215 (40%), Gaps = 22/215 (10%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLM---KELKHE 63 F+ +K+G G + + G N +VA+K + S+ R L+ + + Sbjct: 14 FRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPD 73 Query: 64 NIVRLYDVIHTENKL-TLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 I R+Y + + +V E + L+ + R L V QLL + Sbjct: 74 GIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNI-----CARKFSLKTVLMIAKQLLHRIE 128 Query: 123 FCHENKILHRDLKPQNLLINKRGQ-----LKLGDFGLARAF-------GIPVNTFSSEVV 170 + H +++RD+KP+N LI + + + DFGLA+ + IP S Sbjct: 129 YVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTG 188 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITG 205 T Y + + MG R S D+ + G + + G Sbjct: 189 TARYMSINTHMG-REQSRRDDLEALGHMFMYFLRG 222 >4XHL-A nrPDB Length = 394 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 45/210 (21%), Positives = 81/210 (38%), Gaps = 18/210 (8%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 +F+ K+G+G++ +Y G N +G VA++ + S R + Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSGGVGIPF 67 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 +R + N +V + + L+ + R V Q+ + + H Sbjct: 68 IRWFGREGEYN--AMVIDLLGPSLEDLFNY-----CHRRFSFKTVIMLALQMFCRIQYIH 120 Query: 126 ENKILHRDLKPQNLL--INKRGQ-LKLGDFGLARAF-------GIPVNTFSSEVVTLWYR 175 +HRD+KP N L + +RG + + DFGL++ + IP S T Y Sbjct: 121 GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYA 180 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITG 205 + + +G S D+ S G +L G Sbjct: 181 SVNTHLGIEQ-SRRDDLESLGYVLIYFCKG 209 >4TN6-A nrPDB Length = 318 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 35/158 (22%), Positives = 68/158 (43%), Gaps = 10/158 (6%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 ++++ K+G+G++ +Y G + G VA+K + ++ + +M+ Sbjct: 6 GNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGI 65 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 +R N +V E + L+ + R L V Q++ + + Sbjct: 66 PTIRWCGAEGDYN--VMVMELLGPSLEDLFNF-----CSRKFSLKTVLLLADQMISRIEY 118 Query: 124 CHENKILHRDLKPQNLL--INKRGQL-KLGDFGLARAF 158 H +HRD+KP N L + K+G L + DFGLA+ + Sbjct: 119 IHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKY 156 >4XHH-A nrPDB Length = 403 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 45/210 (21%), Positives = 82/210 (39%), Gaps = 18/210 (8%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 +F+ K+G+G++ +Y G N +G VA++ + S R + Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKYLSGGVGIPF 67 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 +R + N +V + + L+ + R V Q++ + + H Sbjct: 68 IRWFGREGEYN--AMVIDLLGPSLEDLFNY-----CHRKFSFKTVIMLALQMICRVQYIH 120 Query: 126 ENKILHRDLKPQNLL--INKRGQ-LKLGDFGLARAF-------GIPVNTFSSEVVTLWYR 175 +HRD+KP N L + +RG + + DFGL++ + IP S T Y Sbjct: 121 GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYA 180 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITG 205 + + +G S D+ S G +L G Sbjct: 181 SVNTHLGIEQ-SRRDDLESLGYMLIYFCKG 209 >5CLR-A nrPDB Length = 451 Score = 38.5 bits (88), Expect = 0.003, Method: Compositional matrix adjust. Identities = 43/148 (29%), Positives = 69/148 (46%), Gaps = 22/148 (14%) Query: 14 GNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIH 73 G +Y +K G LK VK+D+E T T + + + +L ++ Sbjct: 88 GGKSYCEQFKVYALDDGKTYFLKSVKIDAESLTEFTN----------EKDTLSKLGRLVG 137 Query: 74 TE-NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ-GLAFCHENK--- 128 T N+ T V + +K SR P L +NL K+F W++L ++ CH+ K Sbjct: 138 TFFNEQTQVHYILTTFIKGIDLSRYKNALP--LNVNL-KHF-WEVLGIMISVCHQVKQFH 193 Query: 129 ---ILHRDLKPQNLLINKRGQLKLGDFG 153 ++HRDLKP N++++ Q L DFG Sbjct: 194 ELGLIHRDLKPGNIMLDADMQCHLVDFG 221 >6J6I-B nrPDB Length = 351 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 25/87 (28%), Positives = 41/87 (47%), Gaps = 1/87 (1%) Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYST 188 I+HRD+KP ++ ++K KL D + + + +E V + D L + T Sbjct: 187 IIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVT 246 Query: 189 S-IDIWSCGCILAEMITGKPLFPGTND 214 D++S G L +ITGKP +D Sbjct: 247 EYTDVYSFGICLLVIITGKPAIMTISD 273 >5UU1-A nrPDB Length = 324 Score = 36.6 bits (83), Expect = 0.012, Method: Compositional matrix adjust. Identities = 40/167 (23%), Positives = 69/167 (41%), Gaps = 25/167 (14%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-------------STAIREISLM 57 +K+G+G + +Y A VK++ +E P I++ Sbjct: 22 KKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIER 81 Query: 58 KELKHENIVRLYDVIHTENK----LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYF 113 K+L + I Y TE K +V E + DL+K L+L + Sbjct: 82 KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGI---- 137 Query: 114 QWQLLQGLAFCHENKILHRDLKPQNLLINKRG--QLKLGDFGLARAF 158 ++L L + HEN+ +H D+K NLL+ + Q+ L D+GL+ + Sbjct: 138 --RMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRY 182 >1CSN-A nrPDB Length = 298 Score = 36.6 bits (83), Expect = 0.013, Method: Compositional matrix adjust. Identities = 35/162 (21%), Positives = 64/162 (39%), Gaps = 12/162 (7%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 +K ++G G++ +++G N VA+K S+ R L+ I Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCT--GI 68 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 +Y LV + + L+ +D R + V Q+L + H Sbjct: 69 PNVYYFGQEGLHNVLVIDLLGPSLEDLLDL-----CGRKFSVKTVAMAAKQMLARVQSIH 123 Query: 126 ENKILHRDLKPQNLLINK-----RGQLKLGDFGLARAFGIPV 162 E +++RD+KP N LI + + + DFG+ + + PV Sbjct: 124 EKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPV 165 >2RSV-A nrPDB Length = 403 Score = 36.2 bits (82), Expect = 0.016, Method: Compositional matrix adjust. Identities = 28/92 (30%), Positives = 47/92 (51%), Gaps = 10/92 (10%) Query: 72 IHTENKLTLVFEFMD---NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 +H +N + F MD +DL+K ++ N R V ++L L + HE++ Sbjct: 125 LHDKNGKSYRFMIMDRFGSDLQKIYEA----NAKR-FSRKTVLQLSLRILDILEYIHEHE 179 Query: 129 ILHRDLKPQNLLINKRG--QLKLGDFGLARAF 158 +H D+K NLL+N + Q+ L D+GLA + Sbjct: 180 YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 211 >2LAV-A nrPDB Length = 361 Score = 36.2 bits (82), Expect = 0.019, Method: Compositional matrix adjust. Identities = 28/92 (30%), Positives = 47/92 (51%), Gaps = 10/92 (10%) Query: 72 IHTENKLTLVFEFMD---NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 +H +N + F MD +DL+K ++ N R V ++L L + HE++ Sbjct: 118 LHDKNGKSYRFMIMDRFGSDLQKIYEA----NAKR-FSRKTVLQLSLRILDILEYIHEHE 172 Query: 129 ILHRDLKPQNLLINKRG--QLKLGDFGLARAF 158 +H D+K NLL+N + Q+ L D+GLA + Sbjct: 173 YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 >5UV4-A nrPDB Length = 311 Score = 35.8 bits (81), Expect = 0.024, Method: Compositional matrix adjust. Identities = 43/167 (25%), Positives = 78/167 (46%), Gaps = 18/167 (10%) Query: 52 REISLMKELKHENIV--RLYDVIHTENKLTLVFEFMD-NDLKKYM---DSRTVGNTPRGL 105 REI + ++H N+V R Y E++ ++ ++ D L Y+ D R + G Sbjct: 70 REIKKLGSVRHPNLVPLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQ 129 Query: 106 ELNLVKYFQWQLLQGLAFCHENKIL-HRDLKPQNLLI-NKRGQLKLGDFGLARAFGIPVN 163 LN+ + + L + H +++ H ++K N+LI N + D+ L R P+ Sbjct: 130 RLNIA----IDIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLM-TPIG 184 Query: 164 TFSSEVV---TLWYRAPDVLMGSRTY-STSIDIWSCGCILAEMITGK 206 + +V+ L Y P+ S+ S D+++ G IL E++TGK Sbjct: 185 -MAEQVLNAGALGYSPPEFSSTSKPCPSLKSDVYAFGVILLELLTGK 230 >4BWP-A nrPDB Length = 448 Score = 34.3 bits (77), Expect = 0.062, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 37/70 (52%), Gaps = 6/70 (8%) Query: 19 ATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHT---- 74 AT Y+ + TTG L+ + + T + + + K+L+H N+V+L +V T Sbjct: 64 ATTYRATHNTTGYKYCLRRIHGFRLQSTKCMTL--VEMWKKLQHTNVVQLREVFTTKAFG 121 Query: 75 ENKLTLVFEF 84 +N L LV+++ Sbjct: 122 DNSLVLVYDY 131 >4CYJ-A nrPDB Length = 438 Score = 34.3 bits (77), Expect = 0.077, Method: Compositional matrix adjust. Identities = 35/158 (22%), Positives = 73/158 (46%), Gaps = 16/158 (10%) Query: 21 VYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKE---LKHENIVRLYDVIHT--- 74 VYK N G + AL+ +L+ T AI +++MK+ +K+ +IV +++V T Sbjct: 71 VYKAQNSRNGRHYALR--RLEGYRLTNEKAI--LNVMKDWKKIKNASIVTIHEVFTTREF 126 Query: 75 -ENKLTLVFEF--MDNDLKKYMDSRTVGNT---PRGLELNLVKYFQWQLLQGLAFCHENK 128 ++ L ++F + L+++ GN P + N + + Q+ L H N+ Sbjct: 127 GDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSNR 186 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS 166 + R L+P +++ +++L + +N+ S Sbjct: 187 LAARCLEPSKIILTDINRIRLSACAILDVVQFGMNSRS 224 >5X1R-A nrPDB Length = 302 Score = 34.3 bits (77), Expect = 0.077, Method: Compositional matrix adjust. Identities = 44/233 (18%), Positives = 83/233 (35%), Gaps = 42/233 (18%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKE--------------VKLDSE------E 44 ++F+ E +G G + VY+ + +A+KE + L E + Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 45 GTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRG 104 ++ I+E L+ H ++ + + +F K + ++ P Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQ----PEK 136 Query: 105 LELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT 164 ++ ++ L + H+ LHRD+ N+ I + L DFG AR + Sbjct: 137 IDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARK---EIGN 193 Query: 165 FSSEV----------VTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKP 207 S E + + D G T DI++ G +L +I G P Sbjct: 194 LSDETEIVLKPGFAPIEQYTENSDGEQGPWT-----DIYALGAVLHTLIVGSP 241 >5J0A-A nrPDB Length = 300 Score = 33.9 bits (76), Expect = 0.093, Method: Compositional matrix adjust. Identities = 56/252 (22%), Positives = 102/252 (40%), Gaps = 22/252 (8%) Query: 10 LEKLGNGTYATVY------KGLNKTTGVYVALKEVKLDSEEGT-PSTAIREISLMKELKH 62 ++KLG GT VY +GL+ + + + D + E ++K L H Sbjct: 14 MQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHH 73 Query: 63 ENIVRLYDVIHT-ENKLTLVFEFMD----NDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 NIV + L L E+ NDL + + P + L + + Sbjct: 74 PNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVA----LNM 129 Query: 118 LQGLAFCH-ENKILHRDLKPQNLLINKRGQ-LKLGDFGLARAFGIPVNTFSSEVV---TL 172 +GL + H E K+LH D+K N++I + +K+ D G++ + E T Sbjct: 130 ARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTE 189 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNES 231 ++ + + + + DI++ G L EM+T P +ND++ FD +E+ Sbjct: 190 PWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEA 249 Query: 232 LWPSVTKLPKYN 243 + ++ P N Sbjct: 250 YYAALGTRPPIN 261 >4O1O-A nrPDB Length = 717 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 31/129 (24%), Positives = 59/129 (45%), Gaps = 9/129 (6%) Query: 30 GVYVALKE-----VKLDSEEGTPSTAIREISLMKELK-HENIVRLYDVIHTENKLTLVFE 83 G+Y+ L E VK SE T +E+S ++ + ++N+V Y + L + Sbjct: 361 GIYLGLYEDQEVAVKRFSEGSTRGQ--QEVSCLQSSRANDNVVTFYGSESDGSCLHVCLA 418 Query: 84 FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINK 143 + L++++ + G+ E + L + + H + H+DL+PQN+LI+ Sbjct: 419 LCEYTLQEHLANHR-GDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDS 477 Query: 144 RGQLKLGDF 152 + L DF Sbjct: 478 KNGTFLADF 486 >3MZV-A nrPDB Length = 341 Score = 32.7 bits (73), Expect = 0.18, Method: Compositional matrix adjust. Identities = 34/148 (22%), Positives = 60/148 (40%), Gaps = 40/148 (27%) Query: 109 LVKY---FQWQLLQGLAFCHENKILHRDLKPQ----------NLLINKRGQLKLGDFGLA 155 LV Y F L + F H +LH D+ + NLL + + + +GD+ A Sbjct: 67 LVGYGGPFHVHLAATVEFIHTATLLHDDVVDESRQRRGRPTANLLWDNKSSVLVGDYLFA 126 Query: 156 RAFGIPVNTFSSEVVTLWYRAPDV--------LMGSRTYSTSIDIW------------SC 195 R+F + +T + V+ + A V L ++ +T+ DI+ S Sbjct: 127 RSFQLMTDTGNMRVMEILANASAVIAEGEVLQLTAAQNLATTEDIYLRVIRGKTAALFSA 186 Query: 196 GCILAEMITGKPLFPGTNDEEQLKLIFD 223 + +I G P E+Q++ +FD Sbjct: 187 ATEVGGIIGGAP-------EDQVQALFD 207 >4AZV-A nrPDB Length = 569 Score = 31.6 bits (70), Expect = 0.39, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 22/37 (59%) Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFG 153 LL+ LA + H D++P N++++ R +L DFG Sbjct: 348 LLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDFG 384 >6G4J-A nrPDB Length = 315 Score = 31.6 bits (70), Expect = 0.43, Method: Compositional matrix adjust. Identities = 56/234 (23%), Positives = 96/234 (41%), Gaps = 44/234 (18%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 ++LG G VY L +T+ +VALK V DS +S+ E+ N+++ + Sbjct: 32 KQLGKGANGIVY--LAETSDGHVALK-VSDDS-----------LSITSEV---NVLKSFS 74 Query: 71 VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELN----LVKYF-----QW------ 115 + +T+ F D D Y+ S + +E L+KY +W Sbjct: 75 KAQS---VTMGPSFFDTD-DAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMI 130 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINK-RGQLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 QLL L+ H+ + DLKP NL++ +++ D G G + + T +Y Sbjct: 131 QLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEY-----TEFY 185 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTP 228 G+R S D+++ I+ + K +EQL+ + I G P Sbjct: 186 DRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSL--IEGNP 237 >4AZW-A nrPDB Length = 471 Score = 31.6 bits (70), Expect = 0.46, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 22/37 (59%) Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFG 153 LL+ LA + H D++P N++++ R +L DFG Sbjct: 348 LLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG 384 >5OAT-A nrPDB Length = 411 Score = 31.2 bits (69), Expect = 0.54, Method: Compositional matrix adjust. Identities = 48/191 (25%), Positives = 80/191 (41%), Gaps = 35/191 (18%) Query: 119 QGLAFCHENKILHRDLKPQNLLIN----KRGQLKLGDFGLARA-----FGIPVNTFSSEV 169 +G+A + I HRDLK NLL++ + L + DFG A +P ++ + Sbjct: 164 EGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDK 223 Query: 170 -VTLWYRAPDVLMGSR-TYS----TSIDIWSCGCILAEMITGKPLFPGTN-------DEE 216 AP+++ T+S + D+W+ G I E+ F G + E Sbjct: 224 GGNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEG 283 Query: 217 QLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRP--PRDLRQV--------LQPHTKEPL 266 L + D + T ++L V L K NPN + P ++ Q+ L+P K P Sbjct: 284 DLPKLPDEVPTVIQAL---VANLLKRNPNKRLDPEVAANVCQLFLWAPSTWLKPGLKVPT 340 Query: 267 DGNLMDFLHGL 277 G ++ +L L Sbjct: 341 SGEILQWLLSL 351 >3OYR-A nrPDB Length = 345 Score = 31.2 bits (69), Expect = 0.55, Method: Compositional matrix adjust. Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 15/81 (18%) Query: 112 YFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLK------------LGDFGLARAFG 159 +FQ +L + F H +LH D+ + L +RG++ +GDF ARAF Sbjct: 86 HFQ-KLAAAVEFIHTATLLHDDVVDGSQL--RRGKVAAHLIWGGAQSVLVGDFLFARAFE 142 Query: 160 IPVNTFSSEVVTLWYRAPDVL 180 + V T S + + + RA V+ Sbjct: 143 LMVETNSMKALEILARASRVI 163 >4CI6-B nrPDB Length = 643 Score = 31.2 bits (69), Expect = 0.57, Method: Compositional matrix adjust. Identities = 26/113 (23%), Positives = 49/113 (43%), Gaps = 6/113 (5%) Query: 110 VKYFQWQLLQGLAFCHENKILHRDLKPQNLLINK-RGQLKLGDFGLARAFGIPVNTFSSE 168 +K+ +LL + I+H D+KP N++ ++ G+ + D GL G F+ Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGFTES 217 Query: 169 VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLI 221 ++AP++ +G+ S D++ L I G P + L+ I Sbjct: 218 -----FKAPELGVGNLGASEKSDVFLVVSTLLHGIEGFEKDPEIKPNQGLRFI 265 >2JII-A nrPDB Length = 352 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 13/42 (30%), Positives = 25/42 (59%), Gaps = 2/42 (4%) Query: 116 QLLQGLAFCHENKILHRDLKPQNLLIN--KRGQLKLGDFGLA 155 +LL L F HEN+ +H ++ +N+ ++ + Q+ L +G A Sbjct: 167 RLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFA 208 >4OAU-C nrPDB Length = 699 Score = 29.3 bits (64), Expect = 2.3, Method: Compositional matrix adjust. Identities = 11/22 (50%), Positives = 16/22 (72%) Query: 131 HRDLKPQNLLINKRGQLKLGDF 152 H+DL+PQN+LI+ + L DF Sbjct: 463 HQDLQPQNILIDSKKAAHLADF 484 >4JXN-A nrPDB Length = 334 Score = 28.9 bits (63), Expect = 2.9, Method: Compositional matrix adjust. Identities = 19/74 (25%), Positives = 33/74 (44%), Gaps = 10/74 (13%) Query: 113 FQWQLLQGLAFCHENKILHRDLKPQ----------NLLINKRGQLKLGDFGLARAFGIPV 162 F L + F H +LH D+ + NLL + + + +GD+ +R+F + V Sbjct: 75 FHINLAATVEFIHTATLLHDDVVDESGQRRGRPTANLLWDNKSSVLVGDYLFSRSFQLMV 134 Query: 163 NTFSSEVVTLWYRA 176 T S V+ + A Sbjct: 135 ETGSLRVLDILANA 148 >6EWX-A nrPDB Length = 484 Score = 27.7 bits (60), Expect = 5.7, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 19/32 (59%) Query: 110 VKYFQWQLLQGLAFCHENKILHRDLKPQNLLI 141 V + QL GL E+ I+HRDL +NLL+ Sbjct: 212 VCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 243 >2X8B-A nrPDB Length = 583 Score = 27.7 bits (60), Expect = 5.9, Method: Compositional matrix adjust. Identities = 21/65 (32%), Positives = 24/65 (36%), Gaps = 10/65 (15%) Query: 201 EMITGKPLFPGTNDEEQLKLI----------FDIMGTPNESLWPSVTKLPKYNPNIQQRP 250 E I G PL P N + K+ F G PNE P + P Y QQ Sbjct: 452 EFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYV 511 Query: 251 PRDLR 255 DLR Sbjct: 512 SLDLR 516 >3ENH-A nrPDB Length = 540 Score = 27.7 bits (60), Expect = 6.6, Method: Compositional matrix adjust. Identities = 21/73 (28%), Positives = 37/73 (50%), Gaps = 5/73 (6%) Query: 85 MDNDLKKYMDSRTVGNTPRG-LELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINK 143 +D D K+ M S G + +E NL +++ + + H+N ++H DL N + +K Sbjct: 409 VDLDNKRIMMSYINGKLAKDVIEDNL--DIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDK 466 Query: 144 RGQLKLGDFGLAR 156 L + DFGL + Sbjct: 467 --DLYIIDFGLGK 477 >5VE6-A nrPDB Length = 492 Score = 27.7 bits (60), Expect = 6.7, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 19/32 (59%) Query: 110 VKYFQWQLLQGLAFCHENKILHRDLKPQNLLI 141 V + QL GL E+ I+HRDL +NLL+ Sbjct: 210 VCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 >5DMZ-A nrPDB Length = 365 Score = 26.9 bits (58), Expect = 9.6, Method: Compositional matrix adjust. Identities = 14/43 (32%), Positives = 25/43 (58%), Gaps = 1/43 (2%) Query: 100 NTP-RGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLI 141 NTP + + LV F ++L + H+ +I+H D+KP N ++ Sbjct: 163 NTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFIL 205 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4KRC-A nrPDB 442 e-125 2BPM-A nrPDB 363 e-101 3NIZ-A nrPDB 343 6e-95 6GU6-A nrPDB 342 1e-94 4AU8-A nrPDB 341 3e-94 1V0B-A nrPDB 339 9e-94 5G6V-A nrPDB 314 2e-86 1UA2-A nrPDB 309 1e-84 3GC0-A nrPDB 308 2e-84 4QTB-A nrPDB 302 1e-82 1G3N-A nrPDB 301 2e-82 4EWQ-A nrPDB 300 6e-82 2F9G-A nrPDB 299 9e-82 4AGU-A nrPDB 298 2e-81 5EFQ-A nrPDB 296 7e-81 5NGU-A nrPDB 295 1e-80 4BBM-A nrPDB 295 2e-80 4NST-A nrPDB 294 3e-80 3OHT-A nrPDB 293 7e-80 1CM8-A nrPDB 292 1e-79 4IC8-A nrPDB 290 6e-79 2W96-B nrPDB 289 1e-78 3GC9-A nrPDB 289 2e-78 6DTL-A nrPDB 287 3e-78 5Z33-A nrPDB 287 3e-78 3MIA-A nrPDB 287 5e-78 4QNY-A nrPDB 287 5e-78 4MVF-A nrPDB 286 6e-78 4MYG-A nrPDB 286 9e-78 4ZSG-A nrPDB 286 1e-77 3ZDU-A nrPDB 285 1e-77 3OZ6-A nrPDB 285 2e-77 5JN2-A nrPDB 283 7e-77 5AWM-A nrPDB 281 2e-76 1JNK-A nrPDB 281 2e-76 3E7O-A nrPDB 281 3e-76 3HZT-A nrPDB 281 3e-76 2XS0-A nrPDB 278 2e-75 3DXN-A nrPDB 278 2e-75 4BGQ-A nrPDB 277 3e-75 3LIJ-A nrPDB 277 3e-75 3MA6-A nrPDB 277 5e-75 3NCG-A nrPDB 276 9e-75 2VN9-A nrPDB 275 2e-74 5FG8-A nrPDB 275 2e-74 3FI2-A nrPDB 274 3e-74 3DFA-A nrPDB 273 6e-74 4O2Z-A nrPDB 273 7e-74 3COM-A nrPDB 270 6e-73 5U6Y-A nrPDB 268 2e-72 2V7O-A nrPDB 268 2e-72 2BDW-A nrPDB 267 3e-72 2JC6-A nrPDB 267 4e-72 3BHH-A nrPDB 267 5e-72 2VZ6-A nrPDB 267 5e-72 4FG9-A nrPDB 265 2e-71 3MN3-A nrPDB 264 3e-71 4LG4-A nrPDB 264 3e-71 3KK8-A nrPDB 264 3e-71 5IG1-A nrPDB 264 4e-71 5Y86-A nrPDB 264 4e-71 5XZW-A nrPDB 264 5e-71 6AO5-A nrPDB 263 8e-71 3SOA-A nrPDB 262 2e-70 4YZB-A nrPDB 261 3e-70 4E7W-A nrPDB 261 3e-70 3TAC-A nrPDB 261 3e-70 5ES1-A nrPDB 260 5e-70 4RGJ-A nrPDB 259 9e-70 3RP9-A nrPDB 259 1e-69 3Q5I-A nrPDB 259 2e-69 6FD3-A nrPDB 259 2e-69 5YKS-A nrPDB 258 2e-69 5AIR-A nrPDB 258 2e-69 3PG1-A nrPDB 257 4e-69 3DAK-A nrPDB 257 5e-69 3N9X-A nrPDB 256 9e-69 2QNJ-A nrPDB 255 1e-68 3H4J-B nrPDB 255 1e-68 5KZ7-A nrPDB 255 2e-68 4PDS-A nrPDB 255 2e-68 2UV2-A nrPDB 254 3e-68 2XIK-A nrPDB 254 4e-68 4FIE-A nrPDB 254 4e-68 3D2K-A nrPDB 254 5e-68 4UZD-A nrPDB 253 6e-68 4QMW-A nrPDB 253 6e-68 4REW-A nrPDB 253 6e-68 3E3P-A nrPDB 253 6e-68 2J90-A nrPDB 253 8e-68 2I6L-A nrPDB 252 1e-67 5WAX-A nrPDB 252 1e-67 4CFF-A nrPDB 252 1e-67 3NIE-A nrPDB 252 2e-67 5DBX-A nrPDB 252 2e-67 4JDH-A nrPDB 251 2e-67 5EZV-A nrPDB 251 2e-67 4CZT-A nrPDB 251 3e-67 4XBR-A nrPDB 251 3e-67 2Q0N-A nrPDB 251 3e-67 5KCV-A nrPDB 251 4e-67 3IS5-A nrPDB 250 4e-67 2JAM-A nrPDB 250 5e-67 5J5T-A nrPDB 249 9e-67 3F3Z-A nrPDB 249 1e-66 4CQG-A nrPDB 249 1e-66 3GUB-A nrPDB 249 1e-66 2Y7J-A nrPDB 249 1e-66 3MV5-A nrPDB 249 1e-66 3Q53-A nrPDB 248 2e-66 4CFH-A nrPDB 248 2e-66 2YAB-A nrPDB 248 2e-66 4CSV-A nrPDB 248 2e-66 4NIF-A nrPDB 248 2e-66 5ZTN-A nrPDB 248 2e-66 4D2V-A nrPDB 248 2e-66 4D28-A nrPDB 248 2e-66 4RED-A nrPDB 248 3e-66 2JDO-A nrPDB 247 4e-66 4FZF-B nrPDB 247 4e-66 1PHK-A nrPDB 247 4e-66 4JG6-A nrPDB 247 6e-66 2F57-A nrPDB 247 6e-66 4KS7-A nrPDB 246 8e-66 3EB0-A nrPDB 246 8e-66 2YZA-A nrPDB 245 1e-65 4JXF-A nrPDB 245 2e-65 2YCR-A nrPDB 245 2e-65 6C9D-A nrPDB 245 2e-65 2HAK-A nrPDB 245 2e-65 2X4F-A nrPDB 245 3e-65 6HXF-B nrPDB 244 3e-65 3UC3-A nrPDB 244 5e-65 2A27-A nrPDB 244 5e-65 5D7A-A nrPDB 243 7e-65 1ZWS-A nrPDB 242 1e-64 2W4O-A nrPDB 242 1e-64 5JZN-A nrPDB 242 2e-64 3I6U-A nrPDB 241 3e-64 5D9K-A nrPDB 240 4e-64 3ZUT-A nrPDB 240 5e-64 4B6L-A nrPDB 240 6e-64 4CRL-A nrPDB 240 8e-64 6FDY-U nrPDB 240 8e-64 3UTO-A nrPDB 239 2e-63 3UDB-A nrPDB 239 2e-63 4L42-A nrPDB 238 2e-63 4I6B-A nrPDB 237 5e-63 2Z7Q-A nrPDB 237 5e-63 3HDN-A nrPDB 237 7e-63 1KOA-A nrPDB 236 8e-63 6CMJ-A nrPDB 236 1e-62 1FOT-A nrPDB 235 1e-62 4RLP-A nrPDB 235 1e-62 2HW6-A nrPDB 235 2e-62 3TXO-A nrPDB 235 2e-62 5KKR-C nrPDB 233 5e-62 3DB8-A nrPDB 232 1e-61 5F9E-A nrPDB 232 1e-61 3EQC-A nrPDB 232 1e-61 5LOH-A nrPDB 232 2e-61 2WO6-A nrPDB 231 3e-61 4B8L-A nrPDB 231 3e-61 4YNZ-A nrPDB 231 3e-61 2OU7-A nrPDB 230 4e-61 5YV8-A nrPDB 230 5e-61 5X8I-B nrPDB 230 5e-61 4U41-A nrPDB 230 6e-61 3LM0-A nrPDB 229 1e-60 6O6Q-A nrPDB 229 1e-60 4J52-A nrPDB 229 1e-60 1KOB-A nrPDB 228 2e-60 3HKO-A nrPDB 228 2e-60 4WNO-A nrPDB 228 3e-60 2WQN-A nrPDB 227 4e-60 3ORZ-A nrPDB 227 4e-60 6FYV-A nrPDB 227 5e-60 4RA4-A nrPDB 226 9e-60 1U5R-A nrPDB 226 9e-60 6CQF-A nrPDB 226 1e-59 2GCD-A nrPDB 225 2e-59 6E9W-A nrPDB 225 2e-59 6ED6-A nrPDB 225 2e-59 3ALO-A nrPDB 224 3e-59 2FO0-A nrPDB 224 3e-59 4APC-A nrPDB 224 4e-59 3KN6-A nrPDB 224 4e-59 6CKI-A nrPDB 224 4e-59 4XEY-B nrPDB 223 5e-59 4E93-A nrPDB 223 5e-59 5MJB-A nrPDB 223 5e-59 5X3F-B nrPDB 223 9e-59 4AF3-A nrPDB 223 9e-59 5N23-A nrPDB 223 1e-58 1S9I-A nrPDB 222 1e-58 6QAU-A nrPDB 222 1e-58 4WB7-A nrPDB 222 1e-58 6E2O-A nrPDB 222 1e-58 3NYO-A nrPDB 222 2e-58 4P5Q-A nrPDB 222 2e-58 6NPU-A nrPDB 222 2e-58 3A8W-A nrPDB 222 2e-58 5A46-A nrPDB 222 2e-58 2XYN-A nrPDB 221 3e-58 2H8H-A nrPDB 220 4e-58 2Y6O-A nrPDB 220 4e-58 1VZO-A nrPDB 220 5e-58 5L6P-A nrPDB 220 5e-58 6F3F-A nrPDB 220 6e-58 4EBW-A nrPDB 220 6e-58 3TT0-A nrPDB 220 7e-58 2R2P-A nrPDB 220 7e-58 3DKO-A nrPDB 220 8e-58 4AN9-A nrPDB 219 1e-57 4MD7-E nrPDB 219 1e-57 3GQL-A nrPDB 219 1e-57 1JPA-A nrPDB 219 1e-57 4XLV-A nrPDB 219 1e-57 3VN9-A nrPDB 218 2e-57 2DQ7-X nrPDB 218 2e-57 3PPZ-A nrPDB 218 2e-57 6FEX-A nrPDB 218 2e-57 6GQK-A nrPDB 218 2e-57 4AT3-A nrPDB 218 3e-57 5H2U-A nrPDB 217 3e-57 2BRG-A nrPDB 217 3e-57 2J0K-A nrPDB 217 4e-57 5DYK-A nrPDB 217 4e-57 4XCU-A nrPDB 217 5e-57 6BDL-A nrPDB 217 5e-57 6HMD-A nrPDB 217 6e-57 1NY3-A nrPDB 217 7e-57 2PVN-A nrPDB 216 8e-57 2PSQ-A nrPDB 216 8e-57 5SYS-A nrPDB 216 8e-57 6BSD-A nrPDB 216 8e-57 3PFQ-A nrPDB 216 8e-57 3TKU-A nrPDB 216 1e-56 4K33-A nrPDB 216 1e-56 4TNB-A nrPDB 216 1e-56 4PDO-A nrPDB 216 1e-56 3FME-A nrPDB 215 1e-56 3KA0-A nrPDB 215 1e-56 2OZA-A nrPDB 215 1e-56 4C0T-A nrPDB 215 2e-56 3V5Q-A nrPDB 215 2e-56 4IAN-A nrPDB 215 3e-56 5FET-A nrPDB 214 3e-56 2VWV-A nrPDB 214 3e-56 2I0E-A nrPDB 214 3e-56 4AW2-A nrPDB 214 4e-56 1LUF-A nrPDB 214 4e-56 5EG3-A nrPDB 214 4e-56 6EII-A nrPDB 214 5e-56 5XVU-A nrPDB 213 5e-56 3C51-A nrPDB 213 5e-56 5UNP-A nrPDB 213 5e-56 3FXW-A nrPDB 213 8e-56 2WTK-C nrPDB 213 8e-56 4FR4-A nrPDB 213 1e-55 1TKI-A nrPDB 212 2e-55 3A4O-X nrPDB 212 2e-55 3KUL-B nrPDB 211 2e-55 2OGV-A nrPDB 211 3e-55 2WTK-B nrPDB 210 5e-55 2XNP-A nrPDB 210 8e-55 4OLI-A nrPDB 210 8e-55 5KMM-A nrPDB 210 8e-55 6CCF-A nrPDB 209 1e-54 2VD5-A nrPDB 208 2e-54 5HI2-A nrPDB 208 2e-54 4H1J-A nrPDB 208 2e-54 3CJF-A nrPDB 208 2e-54 1FVR-A nrPDB 208 3e-54 4GS6-A nrPDB 208 3e-54 4PWN-A nrPDB 208 3e-54 4UY9-A nrPDB 207 4e-54 6GVJ-A nrPDB 207 4e-54 3I81-A nrPDB 207 4e-54 6DBM-A nrPDB 207 5e-54 4R7H-A nrPDB 207 5e-54 4OTD-A nrPDB 207 5e-54 3RAW-A nrPDB 207 6e-54 3KRL-A nrPDB 207 6e-54 1K9A-A nrPDB 206 9e-54 2HK5-A nrPDB 206 9e-54 3QGY-A nrPDB 206 1e-53 6FER-A nrPDB 206 1e-53 3DTC-A nrPDB 206 1e-53 3BEA-A nrPDB 205 1e-53 5AMN-A nrPDB 205 1e-53 4UYA-A nrPDB 205 1e-53 5O2B-A nrPDB 205 2e-53 5O2C-A nrPDB 205 2e-53 5VO2-A nrPDB 205 2e-53 5HIE-A nrPDB 205 2e-53 3BBT-B nrPDB 205 2e-53 4XUF-A nrPDB 205 3e-53 5U6B-A nrPDB 205 3e-53 4Y93-A nrPDB 205 3e-53 2PL0-A nrPDB 204 3e-53 4E20-A nrPDB 204 4e-53 5X02-A nrPDB 204 4e-53 6BXI-A nrPDB 203 5e-53 3G0E-A nrPDB 203 5e-53 3OMV-A nrPDB 203 6e-53 4EQM-A nrPDB 203 6e-53 5X5O-A nrPDB 203 6e-53 1BYG-A nrPDB 203 7e-53 6DBN-A nrPDB 203 8e-53 4WUA-A nrPDB 203 8e-53 4HZS-A nrPDB 203 9e-53 3HMP-A nrPDB 203 1e-52 1AD5-A nrPDB 203 1e-52 2OZO-A nrPDB 202 1e-52 1U59-A nrPDB 202 1e-52 5UUU-A nrPDB 202 1e-52 2X7G-A nrPDB 202 2e-52 3PVW-A nrPDB 202 2e-52 4YHJ-A nrPDB 201 3e-52 4KIK-B nrPDB 201 4e-52 4XI2-A nrPDB 200 5e-52 5FM2-A nrPDB 200 5e-52 5AP3-A nrPDB 200 6e-52 2ZMD-A nrPDB 200 7e-52 6E4F-A nrPDB 200 7e-52 5GRN-A nrPDB 200 9e-52 5GNK-A nrPDB 199 1e-51 5HLW-A nrPDB 199 1e-51 3C1X-A nrPDB 199 1e-51 4CRS-A nrPDB 199 1e-51 3SXS-A nrPDB 199 2e-51 3ZBF-A nrPDB 198 2e-51 3LZB-A nrPDB 198 2e-51 1U54-B nrPDB 198 2e-51 5B2L-A nrPDB 198 3e-51 3DLS-A nrPDB 198 3e-51 2JD5-A nrPDB 197 4e-51 4M7I-A nrPDB 197 5e-51 5TOS-A nrPDB 197 5e-51 3QA8-A nrPDB 197 6e-51 3QUP-A nrPDB 196 8e-51 5UIU-A nrPDB 195 2e-50 3PP0-A nrPDB 195 2e-50 1ZXE-A nrPDB 195 2e-50 5U6C-A nrPDB 195 2e-50 4LFI-A nrPDB 195 2e-50 4LRM-A nrPDB 194 4e-50 3AOX-A nrPDB 194 4e-50 3ORP-A nrPDB 193 6e-50 6CTH-A nrPDB 193 8e-50 3ZZW-A nrPDB 193 9e-50 2W1I-A nrPDB 193 9e-50 3IO7-A nrPDB 192 2e-49 4HVI-A nrPDB 191 3e-49 5TQX-A nrPDB 191 3e-49 4YFF-A nrPDB 191 3e-49 3LLT-A nrPDB 191 4e-49 3PLS-A nrPDB 191 4e-49 5TUR-A nrPDB 189 1e-48 6J5U-C nrPDB 188 2e-48 5LPZ-A nrPDB 188 2e-48 5LPV-A nrPDB 188 3e-48 3BGP-A nrPDB 187 4e-48 5HVK-A nrPDB 187 4e-48 5VD3-A nrPDB 187 6e-48 5O0Y-A nrPDB 187 6e-48 4RC3-A nrPDB 187 7e-48 3UIM-A nrPDB 186 9e-48 4F0G-A nrPDB 186 9e-48 5WNO-A nrPDB 185 1e-47 3M42-A nrPDB 185 2e-47 4NEU-A nrPDB 185 3e-47 4X7Q-B nrPDB 183 7e-47 4C59-A nrPDB 182 1e-46 4TPT-A nrPDB 182 2e-46 4JLC-A nrPDB 181 4e-46 4EUU-A nrPDB 181 4e-46 2RIO-A nrPDB 180 6e-46 5WNL-A nrPDB 180 9e-46 3Q4U-A nrPDB 180 9e-46 2A1A-B nrPDB 180 1e-45 4EUT-A nrPDB 179 1e-45 2PMN-X nrPDB 179 1e-45 4PL5-B nrPDB 178 3e-45 4Y83-A nrPDB 178 3e-45 3SOC-A nrPDB 178 4e-45 6NT9-A nrPDB 176 9e-45 6O8B-A nrPDB 176 9e-45 6HV0-A nrPDB 176 1e-44 3UIU-A nrPDB 176 1e-44 4FL3-A nrPDB 175 2e-44 3MDY-A nrPDB 175 3e-44 6B2Q-A nrPDB 175 3e-44 4X3F-A nrPDB 175 3e-44 4OW8-A nrPDB 175 3e-44 1PY5-A nrPDB 173 1e-43 2QKW-B nrPDB 171 2e-43 5C26-A nrPDB 171 3e-43 3QD2-B nrPDB 171 3e-43 4F9B-A nrPDB 171 5e-43 3MY0-A nrPDB 170 6e-43 5XD6-A nrPDB 170 6e-43 4IDT-A nrPDB 169 1e-42 3LMG-A nrPDB 167 6e-42 2QLU-A nrPDB 166 8e-42 3G2F-A nrPDB 165 3e-41 4G3E-A nrPDB 164 5e-41 2BUJ-A nrPDB 164 5e-41 5AR8-A nrPDB 160 7e-40 5CEK-A nrPDB 159 1e-39 6DC0-A nrPDB 159 2e-39 2H34-A nrPDB 158 2e-39 3SV0-A nrPDB 158 3e-39 4M66-A nrPDB 156 8e-39 5TE0-A nrPDB 156 9e-39 6BFN-A nrPDB 156 1e-38 2Y4I-B nrPDB 155 2e-38 4BTK-A nrPDB 154 5e-38 2CHL-A nrPDB 153 9e-38 4NFN-A nrPDB 153 1e-37 4M69-B nrPDB 152 2e-37 4MWI-A nrPDB 152 2e-37 4BTF-A nrPDB 152 2e-37 5E8V-A nrPDB 152 2e-37 4LQP-A nrPDB 151 4e-37 5IKW-A nrPDB 150 1e-36 2C47-A nrPDB 148 2e-36 5FQD-C nrPDB 148 2e-36 2CMW-A nrPDB 148 4e-36 5X18-A nrPDB 147 7e-36 5VC6-A nrPDB 145 2e-35 5VDK-A nrPDB 142 2e-34 5L2Q-C nrPDB 142 2e-34 3VHK-A nrPDB 141 5e-34 4NT4-A nrPDB 140 6e-34 3HNG-A nrPDB 135 2e-32 5USZ-A nrPDB 134 5e-32 4L00-A nrPDB 133 1e-31 4RT7-A nrPDB 129 1e-30 5C01-A nrPDB 128 3e-30 4WOV-A nrPDB 128 4e-30 4XHL-A nrPDB 126 1e-29 4L68-A nrPDB 125 2e-29 2PZI-A nrPDB 124 5e-29 4Y12-A nrPDB 124 6e-29 5M07-A nrPDB 121 5e-28 4JRN-A nrPDB 117 8e-27 4IX6-A nrPDB 90 9e-19 Sequences not found previously or not previously below threshold: 5J0A-A nrPDB 143 7e-35 4TN6-A nrPDB 143 1e-34 1CSN-A nrPDB 136 1e-32 4XHH-A nrPDB 129 2e-30 5X1R-A nrPDB 120 7e-28 5UV4-A nrPDB 111 5e-25 3REP-A nrPDB 109 2e-24 6J6I-B nrPDB 105 2e-23 5OAT-A nrPDB 103 1e-22 4I94-A nrPDB 102 2e-22 6EQI-C nrPDB 93 2e-19 5UU1-A nrPDB 88 3e-18 5CLR-A nrPDB 87 8e-18 4O1O-A nrPDB 80 1e-15 2RSV-A nrPDB 80 2e-15 2LAV-A nrPDB 78 4e-15 4CI6-B nrPDB 75 4e-14 6EAS-A nrPDB 74 8e-14 4OAU-C nrPDB 73 2e-13 5DMZ-A nrPDB 69 3e-12 6G4J-A nrPDB 67 1e-11 5GZ9-A nrPDB 65 4e-11 5GZA-A nrPDB 65 5e-11 2JII-A nrPDB 63 1e-10 4CYJ-A nrPDB 58 4e-09 6R5K-O nrPDB 57 1e-08 6EWX-A nrPDB 57 1e-08 6M7Z-A nrPDB 56 3e-08 4BWP-A nrPDB 55 3e-08 4XR7-L nrPDB 55 4e-08 4AZW-A nrPDB 54 8e-08 4AZV-A nrPDB 53 2e-07 6BHC-A nrPDB 51 5e-07 5VE6-A nrPDB 49 2e-06 3ENH-A nrPDB 48 4e-06 3Q60-A nrPDB 47 1e-05 6G38-A nrPDB 47 1e-05 3BYV-A nrPDB 45 3e-05 4WWA-A nrPDB 45 4e-05 4CZY-B nrPDB 45 4e-05 2W1Z-A nrPDB 44 1e-04 3DZO-A nrPDB 43 2e-04 1TQM-A nrPDB 39 0.002 5YK0-A nrPDB 39 0.002 6G18-v nrPDB 36 0.014 6FDN-A nrPDB 35 0.036 6BQ8-A nrPDB 32 0.32 6FAI-l nrPDB 31 0.50 4BVU-A nrPDB 31 0.53 5JY7-I nrPDB 31 0.97 5L3X-B nrPDB 30 1.1 >4KRC-A nrPDB Length = 317 Score = 442 bits (1138), Expect = e-125, Method: Composition-based stats. Identities = 305/305 (100%), Positives = 305/305 (100%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL Sbjct: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG Sbjct: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL Sbjct: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP Sbjct: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY Sbjct: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 Query: 301 YHHAS 305 YHHAS Sbjct: 301 YHHAS 305 >2BPM-A nrPDB Length = 309 Score = 363 bits (931), Expect = e-101, Method: Composition-based stats. Identities = 165/304 (54%), Positives = 218/304 (71%), Gaps = 10/304 (3%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKE 59 + F+++EK+G GTY VYK NK TG VALK+++LD+E EG PSTAIREISL+KE Sbjct: 3 LVDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKE 62 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 L H NIV+L DVIHTENKL LVFEF+ DLKK+MD+ + G+ L L+K + +QLLQ Sbjct: 63 LNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALT----GIPLPLIKSYLFQLLQ 118 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 GLAFCH +++LHRDLKPQNLLIN G +KL DFGLARAFG+PV T++ EVVTLWYRAP++ Sbjct: 119 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 178 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 L+G + YST++DIWS GCI AEM+T + LFPG ++ +QL IF +GTP+E +WP VT + Sbjct: 179 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 238 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 P Y P+ + +D +V+ P LD + L +L +P+ R+SAK AL HP+F + Sbjct: 239 PDYKPSFPKWARQDFSKVVPP-----LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 293 Query: 300 YYHH 303 Sbjct: 294 VTKP 297 >3NIZ-A nrPDB Length = 311 Score = 343 bits (880), Expect = 6e-95, Method: Composition-based stats. Identities = 163/300 (54%), Positives = 210/300 (70%), Gaps = 11/300 (3%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKH 62 ++++LEK+G GTY VYK + + G VALK ++LD+E EG PSTAIREISL+KEL H Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLDAEDEGIPSTAIREISLLKELHH 78 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 NIV L DVIH+E LTLVFEFM+ DLKK +D GL+ + +K + +QLL+G+A Sbjct: 79 PNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKT-----GLQDSQIKIYLYQLLRGVA 133 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 CH+++ILHRDLKPQNLLIN G LKL DFGLARAFGIPV +++ EVVTLWYRAPDVLMG Sbjct: 134 HCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMG 193 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 S+ YSTS+DIWS GCI AEMITGKPLFPG D++QL IF I+GTPN WP V +LP + Sbjct: 194 SKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLW 253 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYH 302 +QR + + +D L +L +P+ R+SA+ A++HP+F + Sbjct: 254 ----KQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLDP 309 >6GU6-A nrPDB Length = 302 Score = 342 bits (877), Expect = 1e-94, Method: Composition-based stats. Identities = 151/303 (49%), Positives = 208/303 (68%), Gaps = 9/303 (2%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE-GTPSTAIREISLMKE 59 + S + ++EK+G GTY VYKG +KTTG VA+K+++L+SEE G PSTAIREISL+KE Sbjct: 3 LGSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKE 62 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 L+H NIV L DV+ +++L L+FEF+ DLKKY+DS + ++ +LVK + +Q+LQ Sbjct: 63 LRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDS---IPPGQYMDSSLVKSYLYQILQ 119 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 G+ FCH ++LHRDLKPQNLLI+ +G +KL DFGLARAFGIP+ ++ EVVTLWYR+P+V Sbjct: 120 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 179 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 L+GS YST +DIWS G I AE+ T KPLF G ++ +QL IF +GTPN +WP V L Sbjct: 180 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 239 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 Y + P L + + LD N +D L +L +P R+S K AL+HP+F + Sbjct: 240 QDYKNTFPKWKPGSLASHV-----KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 294 Query: 300 YYH 302 + Sbjct: 295 LDN 297 >4AU8-A nrPDB Length = 296 Score = 341 bits (874), Expect = 3e-94, Method: Composition-based stats. Identities = 167/302 (55%), Positives = 214/302 (70%), Gaps = 12/302 (3%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKH 62 S ++++LEK+G GTY TV+K N+ T VALK V+LD + EG PS+A+REI L+KELKH Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 64 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 +NIVRL+DV+H++ KLTLVFEF D DLKKY DS L+ +VK F +QLL+GL Sbjct: 65 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDS-----CNGDLDPEIVKSFLFQLLKGLG 119 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 FCH +LHRDLKPQNLLIN+ G+LKL DFGLARAFGIPV +S+EVVTLWYR PDVL G Sbjct: 120 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 179 Query: 183 SRTYSTSIDIWSCGCILAEMI-TGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 ++ YSTSID+WS GCI AE+ G+PLFPG + ++QLK IF ++GTP E WPS+TKLP Sbjct: 180 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD 239 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 Y P L V+ L+ D L LL+ NP R+SA++AL HP+F+++ Sbjct: 240 YKPYPMYPATTSLVNVVPK-----LNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 294 Query: 302 HH 303 Sbjct: 295 PP 296 >1V0B-A nrPDB Length = 288 Score = 339 bits (870), Expect = 9e-94, Method: Composition-based stats. Identities = 166/297 (55%), Positives = 210/297 (70%), Gaps = 12/297 (4%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKH 62 ++ LEK+G GTY VYK N G ALK+++L+ E EG PST IREIS++KELKH Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 NIV+LYDVIHT+ +L LVFE +D DLKK +D GLE K F QLL G+A Sbjct: 60 SNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLD-----VCEGGLESVTAKSFLLQLLNGIA 114 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 +CH+ ++LHRDLKPQNLLIN+ G+LK+ DFGLARAFGIPV ++ EVVTLWYRAPDVLMG Sbjct: 115 YCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMG 174 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 S+ YST+IDIWS GCI AEM+ G PLFPG ++ +QL IF I+GTPN WP+VT+LPKY Sbjct: 175 SKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKY 234 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 +PN P L+ LD + +D L +L+L+P+ R++AKQAL H +F E Sbjct: 235 DPNFTVYEPLPWESFLKG-----LDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >5G6V-A nrPDB Length = 324 Score = 314 bits (806), Expect = 2e-86, Method: Composition-based stats. Identities = 158/300 (52%), Positives = 202/300 (67%), Gaps = 9/300 (3%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 + +L+KLG GTYATVYKG +K T VALKE++L+ EEG P TAIRE+SL+K+LKH Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 60 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 NIV L+D+IHTE LTLVFE++D DLK+Y+D + + ++ VK F +QLL+GLA+ Sbjct: 61 NIVTLHDIIHTEKSLTLVFEYLDKDLKQYLD-----DCGNIINMHNVKLFLFQLLRGLAY 115 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 CH K+LHRDLKPQNLLIN+RG+LKL DFGLARA IP T+ +EVVTLWYR PD+L+GS Sbjct: 116 CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGS 175 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 YST ID+W GCI EM TG+PLFPG+ EEQL IF I+GTP E WP + ++ Sbjct: 176 TDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFK 235 Query: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHH 303 P+ + L H LD + D L LLQ R+SA+ A+ HP+F Sbjct: 236 TY---NYPKYRAEALLSHAPR-LDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGER 291 >1UA2-A nrPDB Length = 346 Score = 309 bits (792), Expect = 1e-84, Method: Composition-based stats. Identities = 119/301 (39%), Positives = 184/301 (61%), Gaps = 15/301 (4%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKL----DSEEGTPSTAIREISLM 57 S + ++++L+ LG G +ATVYK +K T VA+K++KL ++++G TA+REI L+ Sbjct: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 Query: 58 KELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 +EL H NI+ L D ++ ++LVF+FM+ DL+ + ++ L + +K + Sbjct: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV-----LTPSHIKAYMLMT 121 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 LQGL + H++ ILHRDLKP NLL+++ G LKL DFGLA++FG P ++ +VVT WYRAP Sbjct: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 ++L G+R Y +D+W+ GCILAE++ P PG +D +QL IF+ +GTP E WP + Sbjct: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 LP Y + P L + +L+D + GL NP R++A QAL +F Sbjct: 242 SLPDYV-TFKSFPGIPLHHIFSAAG-----DDLLDLIQGLFLFNPCARITATQALKMKYF 295 Query: 298 A 298 + Sbjct: 296 S 296 >3GC0-A nrPDB Length = 329 Score = 308 bits (790), Expect = 2e-84, Method: Composition-based stats. Identities = 138/304 (45%), Positives = 203/304 (66%), Gaps = 16/304 (5%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD-SEEGTPSTAIREISLMKEL 60 +S +++++ KLG GTY VYK ++ T VA+K ++L+ EEG P TAIRE+SL+KEL Sbjct: 31 TSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKEL 90 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +H NI+ L VIH ++L L+FE+ +NDLKKYMD + + ++K F +QL+ G Sbjct: 91 QHRNIIELKSVIHHNHRLHLIFEYAENDLKKYMDKNP------DVSMRVIKSFLYQLING 144 Query: 121 LAFCHENKILHRDLKPQNLLIN-----KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 + FCH + LHRDLKPQNLL++ + LK+GDFGLARAFGIP+ F+ E++TLWYR Sbjct: 145 VNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYR 204 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 P++L+GSR YSTS+DIWS CI AEM+ PLFPG ++ +QL IF+++G P+++ WP Sbjct: 205 PPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPG 264 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 VT LP + + + + L++VL + L +L+++P R+SAK AL HP Sbjct: 265 VTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLT----AMLEMDPVKRISAKNALEHP 320 Query: 296 WFAE 299 +F+ Sbjct: 321 YFSH 324 >4QTB-A nrPDB Length = 380 Score = 302 bits (774), Expect = 1e-82, Method: Composition-based stats. Identities = 99/308 (32%), Positives = 164/308 (53%), Gaps = 18/308 (5%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 ++ QL+ +G G Y V + VA+K++ + +REI ++ +HEN+ Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENV 101 Query: 66 VRLYDVIHTEN-----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 + + D++ + +V + M+ DL K + S+ + N + + YF +Q+L+G Sbjct: 102 IGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSN-------DHICYFLYQILRG 154 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT---FSSEVVTLWYRAP 177 L + H +LHRDLKP NLLIN LK+ DFGLAR + + V T WYRAP Sbjct: 155 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 214 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 ++++ S+ Y+ SIDIWS GCILAEM++ +P+FPG + +QL I I+G+P++ + Sbjct: 215 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 274 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + K +Q P + +V D +D L +L NP+ R++ ++AL HP+ Sbjct: 275 NM-KARNYLQSLPSK--TKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 331 Query: 298 AEYYHHAS 305 +YY Sbjct: 332 EQYYDPTD 339 >1G3N-A nrPDB Length = 326 Score = 301 bits (772), Expect = 2e-82, Method: Composition-based stats. Identities = 125/310 (40%), Positives = 180/310 (58%), Gaps = 23/310 (7%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLN-KTTGVYVALKEVKLDS-EEGTPSTAIREISLMKEL 60 + Q++ + ++G G Y V+K + K G +VALK V++ + EEG P + IRE+++++ L Sbjct: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68 Query: 61 K---HENIVRLYDVIH-----TENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKY 112 + H N+VRL+DV E KLTLVFE +D DL Y+D G+ +K Sbjct: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKV----PEPGVPTETIKD 124 Query: 113 FQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTL 172 +QLL+GL F H ++++HRDLKPQN+L+ GQ+KL DFGLAR + + +S VVTL Sbjct: 125 MMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTL 183 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESL 232 WYRAP+VL+ S +Y+T +D+WS GCI AEM KPLF G++D +QL I D++G P E Sbjct: 184 WYRAPEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEED 242 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 WP LP+ + + P +D D L L NP R+SA AL Sbjct: 243 WPRDVALPRQAFHSKSAQP-------IEKFVTDIDELGKDLLLKCLTFNPAKRISAYSAL 295 Query: 293 HHPWFAEYYH 302 HP+F + Sbjct: 296 SHPYFQDLER 305 >4EWQ-A nrPDB Length = 383 Score = 300 bits (768), Expect = 6e-82, Method: Composition-based stats. Identities = 103/309 (33%), Positives = 166/309 (53%), Gaps = 24/309 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKH 62 +++ L +G+G Y +V + TG+ VA+K++ + RE+ L+K +KH Sbjct: 44 PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKH 103 Query: 63 ENIVRLYDVI------HTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 EN++ L DV N + LV M DL + + L + V++ +Q Sbjct: 104 ENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-------QKLTDDHVQFLIYQ 156 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 +L+GL + H I+HRDLKP NL +N+ +LK+ DFGLAR + + V T WYRA Sbjct: 157 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRA 213 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P++++ Y+ ++DIWS GCI+AE++TG+ LFPGT+ +QLKLI ++GTP L + Sbjct: 214 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 273 Query: 237 T--KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 + Y ++ Q P + V + +D L +L L+ D R++A QAL H Sbjct: 274 SSESARNYIQSLTQMPKMNFANVFIG-----ANPLAVDLLEKMLVLDSDKRITAAQALAH 328 Query: 295 PWFAEYYHH 303 +FA+Y+ Sbjct: 329 AYFAQYHDP 337 >2F9G-A nrPDB Length = 353 Score = 299 bits (767), Expect = 9e-82, Method: Composition-based stats. Identities = 103/315 (32%), Positives = 162/315 (51%), Gaps = 24/315 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 SS F+ LG G Y V +K TG VA+K+++ + +REI ++K KHE Sbjct: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 Query: 64 NIVRLY-----DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 NI+ ++ D N++ ++ E M DL + + + + L + ++YF +Q L Sbjct: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST-------QMLSDDHIQYFIYQTL 122 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIP----------VNTFSSE 168 + + H + ++HRDLKP NLLIN LK+ DFGLAR + + Sbjct: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 Query: 169 VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTP 228 V T WYRAP+V++ S YS ++D+WSCGCILAE+ +P+FPG + QL LIF I+GTP Sbjct: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 Query: 229 NESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA 288 + + P+ I+ P + ++ +D L +L +P R++A Sbjct: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPL--EKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 Query: 289 KQALHHPWFAEYYHH 303 K+AL HP+ Y+ Sbjct: 301 KEALEHPYLQTYHDP 315 >4AGU-A nrPDB Length = 311 Score = 298 bits (763), Expect = 2e-81, Method: Composition-based stats. Identities = 105/298 (35%), Positives = 169/298 (56%), Gaps = 11/298 (3%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKE-VKLDSEEGTPSTAIREISLMKELK 61 +++++ K+G G+Y V+K N+ TG VA+K+ ++ + + A+REI ++K+LK Sbjct: 1 MMEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK 60 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H N+V L +V + +L LVFE+ D+ + +D RG+ +LVK WQ LQ + Sbjct: 61 HPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQ-----RGVPEHLVKSITWQTLQAV 115 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 FCH++ +HRD+KP+N+LI K +KL DFG AR P + + EV T WYR+P++L+ Sbjct: 116 NFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLV 175 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 G Y +D+W+ GC+ AE+++G PL+PG +D +QL LI +G L P ++ Sbjct: 176 GDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLG----DLIPRHQQVFS 231 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEP-LDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 N D + K P + + L G L ++P RL+ +Q LHHP+F Sbjct: 232 TNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFE 289 >5EFQ-A nrPDB Length = 347 Score = 296 bits (758), Expect = 7e-81, Method: Composition-based stats. Identities = 119/310 (38%), Positives = 184/310 (59%), Gaps = 21/310 (6%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHE 63 +F + +G GTY VYK +K TG VALK+V+LD+E EG P TAIREI ++++L H+ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 64 NIVRLYDVIHTENK----------LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYF 113 +I+ + +++ + LVFE+MD+DL ++S V N +K F Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVH-----FNENHIKSF 125 Query: 114 QWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT-FSSEVVTL 172 QL++GL +CH+ LHRD+K N+L+N RGQ+KL DFGLAR + + ++++V+TL Sbjct: 126 MRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITL 185 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESL 232 WYR P++L+G Y+ +ID+WSCGCIL E+ T KP+F + QL+LI I G+P ++ Sbjct: 186 WYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAV 245 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 WP V KLP +N +P + R+ L+ + +D +L L+P R +A+QAL Sbjct: 246 WPDVIKLPYFN---TMKPKKQYRRKLREEFVF-IPAAALDLFDYMLALDPSKRCTAEQAL 301 Query: 293 HHPWFAEYYH 302 + + Sbjct: 302 QCEFLRDVEP 311 >5NGU-A nrPDB Length = 381 Score = 295 bits (756), Expect = 1e-80, Method: Composition-based stats. Identities = 100/308 (32%), Positives = 162/308 (52%), Gaps = 18/308 (5%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 ++ L +G G Y V + V VA+K++ + +REI ++ +HENI Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENI 102 Query: 66 VRLYDVIHTEN-----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 + + D+I + +V + M+ DL K + ++ + N + + YF +Q+L+G Sbjct: 103 IGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSN-------DHICYFLYQILRG 155 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT---FSSEVVTLWYRAP 177 L + H +LHRDLKP NLL+N LK+ DFGLAR + + V T WYRAP Sbjct: 156 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 215 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 ++++ S+ Y+ SIDIWS GCILAEM++ +P+FPG + +QL I I+G+P++ + Sbjct: 216 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 275 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 L K + P ++ +V D +D L +L NP R+ +QAL HP+ Sbjct: 276 NL-KARNYLLSLPHKN--KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 332 Query: 298 AEYYHHAS 305 +YY + Sbjct: 333 EQYYDPSD 340 >4BBM-A nrPDB Length = 331 Score = 295 bits (755), Expect = 2e-80, Method: Composition-based stats. Identities = 102/299 (34%), Positives = 165/299 (55%), Gaps = 9/299 (3%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKE-VKLDSEEGTPSTAIREISLMKE 59 S +++ L +G G+Y V K NK TG VA+K+ ++ D ++ A+REI L+K+ Sbjct: 21 FQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQ 80 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 L+HEN+V L +V + + LVFEF+D+ + ++ P GL+ +V+ + +Q++ Sbjct: 81 LRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELF-----PNGLDYQVVQKYLFQIIN 135 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 G+ FCH + I+HRD+KP+N+L+++ G +KL DFG AR P + EV T WYRAP++ Sbjct: 136 GIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPEL 195 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 L+G Y ++D+W+ GC++ EM G+PLFPG +D +QL I +G K Sbjct: 196 LVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKN 255 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 P + R P + L ++D L ++PD R + LHH +F Sbjct: 256 PVFAGV---RLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >4NST-A nrPDB Length = 351 Score = 294 bits (754), Expect = 3e-80, Method: Composition-based stats. Identities = 116/307 (37%), Positives = 181/307 (58%), Gaps = 21/307 (6%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHE 63 +F + +G GTY VYK +K TG VALK+V+LD+E EG P TAIREI ++++L H Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 64 NIVRLYDVIHTENK----------LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYF 113 ++V + +++ + LVFE+MD+DL ++S V + +K F Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVH-----FSEDHIKSF 127 Query: 114 QWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT-FSSEVVTL 172 QL++GL +CH+ LHRD+K N+L+N GQ+KL DFGLAR + + ++++V+TL Sbjct: 128 MKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITL 187 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESL 232 WYR P++L+G Y+ +ID+WSCGCIL E+ T KP+F + QL+LI + G+P ++ Sbjct: 188 WYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAV 247 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 WP V KLP +N +P + R+ L+ +D L +L L+P R +A+Q L Sbjct: 248 WPDVIKLPYFN---TMKPKKQYRRRLREEFSFIPSA-ALDLLDHMLTLDPSKRCTAEQTL 303 Query: 293 HHPWFAE 299 + + Sbjct: 304 QSDFLKD 310 >3OHT-A nrPDB Length = 389 Score = 293 bits (750), Expect = 7e-80, Method: Composition-based stats. Identities = 99/309 (32%), Positives = 166/309 (53%), Gaps = 24/309 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKH 62 +++ L +G+G Y +V + +G+ +A+K++ + RE+ L+K +KH Sbjct: 50 PERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKH 109 Query: 63 ENIVRLYDVI------HTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 EN++ L DV N + LV M DL + + L + V++ +Q Sbjct: 110 ENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKC-------QKLTDDHVQFLIYQ 162 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 +L+GL + H I+HRDLKP NL +N+ +LK+ DFGLAR + + V T WYRA Sbjct: 163 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRA 219 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P++++ Y+ ++DIWS GCI+AE++TG+ LFPGT+ QL+ I + GTP S+ + Sbjct: 220 PEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRM 279 Query: 237 T--KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 + Y ++ Q P R+ V + +D L +L L+ D R++A +AL H Sbjct: 280 PSHEARNYINSLPQMPKRNFADVFIG-----ANPLAVDLLEKMLVLDTDKRITASEALAH 334 Query: 295 PWFAEYYHH 303 P+F++Y+ Sbjct: 335 PYFSQYHDP 343 >1CM8-A nrPDB Length = 367 Score = 292 bits (748), Expect = 1e-79, Method: Composition-based stats. Identities = 102/305 (33%), Positives = 163/305 (53%), Gaps = 24/305 (7%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHENI 65 ++ L+ +G+G Y V ++ TG VA+K++ + E A RE+ L+K ++HEN+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 66 VRLYDVIHTENKL------TLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 + L DV + L LV FM DL K M +G + +++ +Q+L+ Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG-------EDRIQFLVYQMLK 139 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 GL + H I+HRDLKP NL +N+ +LK+ DFGLAR + + VVT WYRAP+V Sbjct: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD---SEMTGYVVTRWYRAPEV 196 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT-- 237 ++ Y+ ++DIWS GCI+AEMITGK LF G++ +QLK I + GTP + Sbjct: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + Y + + +D +L ++ L +L L+ + R++A +AL HP+F Sbjct: 257 EAKNYMKGLPELEKKDFASILT-----NASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 Query: 298 AEYYH 302 + Sbjct: 312 ESLHD 316 >4IC8-A nrPDB Length = 442 Score = 290 bits (742), Expect = 6e-79, Method: Composition-based stats. Identities = 101/313 (32%), Positives = 167/313 (53%), Gaps = 24/313 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKH 62 +++ +E +GNG Y V + TG VA+K++ + T +RE+ ++K KH Sbjct: 54 GDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKH 113 Query: 63 ENIVRLYDV------IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 +NI+ + D+ + +V + M++DL + + S + L L V+YF +Q Sbjct: 114 DNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHS------SQPLTLEHVRYFLYQ 167 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIP----VNTFSSEVVTL 172 LL+GL + H +++HRDLKP NLL+N+ +LK+GDFG+AR + V T Sbjct: 168 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 227 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESL 232 WYRAP++++ Y+ +ID+WS GCI EM+ + LFPG N QL+LI ++GTP+ ++ Sbjct: 228 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 287 Query: 233 WPSV--TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 +V ++ Y ++ R P V D + L +L+ P R+SA Sbjct: 288 IQAVGAERVRAYIQSLPPRQPVPWETVYPG-----ADRQALSLLGRMLRFEPSARISAAA 342 Query: 291 ALHHPWFAEYYHH 303 AL HP+ A+Y+ Sbjct: 343 ALRHPFLAKYHDP 355 >2W96-B nrPDB Length = 306 Score = 289 bits (739), Expect = 1e-78, Method: Composition-based stats. Identities = 125/304 (41%), Positives = 180/304 (59%), Gaps = 22/304 (7%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELK 61 ++S+++ + ++G G Y TVYK + +G +VALK V++ + EEG P + +RE++L++ L+ Sbjct: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLE 61 Query: 62 ---HENIVRLYDVIHTEN-----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYF 113 H N+VRL DV T K+TLVFE +D DL+ Y+D P GL +K Sbjct: 62 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKA----PPPGLPAETIKDL 117 Query: 114 QWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW 173 Q L+GL F H N I+HRDLKP+N+L+ G +KL DFGLAR + + VVTLW Sbjct: 118 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALDPVVVTLW 176 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 YRAP+VL+ S TY+T +D+WS GCI AEM KPLF G ++ +QL IFD++G P E W Sbjct: 177 YRAPEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 235 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 P LP R PR ++ V+ ++ + L +L NP R+SA +AL Sbjct: 236 PRDVSLP--RGAFPPRGPRPVQSVVPE-----MEESGAQLLLEMLTFNPHKRISAFRALQ 288 Query: 294 HPWF 297 H + Sbjct: 289 HSYL 292 >3GC9-A nrPDB Length = 370 Score = 289 bits (739), Expect = 2e-78, Method: Composition-based stats. Identities = 97/309 (31%), Positives = 164/309 (53%), Gaps = 24/309 (7%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKHEN 64 + + L +G+G Y +V + VA+K++ + RE+ L+K LKHEN Sbjct: 29 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 88 Query: 65 IVRLYDVI------HTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 ++ L DV +++ LV M DL + S + L V++ +QLL Sbjct: 89 VIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKS-------QALSDEHVQFLVYQLL 141 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 +GL + H I+HRDLKP N+ +N+ +L++ DFGLAR + V T WYRAP+ Sbjct: 142 RGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQAD---EEMTGYVATRWYRAPE 198 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 +++ Y+ ++DIWS GCI+AE++ GK LFPG++ +QLK I +++GTP+ + ++ Sbjct: 199 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 258 Query: 239 --LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 Y ++ P +DL + + + +D L +L L+ D R+SA +AL H + Sbjct: 259 EHARTYIQSLPPMPQKDLSSIFRG-----ANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 313 Query: 297 FAEYYHHAS 305 F++Y+ Sbjct: 314 FSQYHDPED 322 >6DTL-A nrPDB Length = 364 Score = 287 bits (736), Expect = 3e-78, Method: Composition-based stats. Identities = 99/299 (33%), Positives = 157/299 (52%), Gaps = 17/299 (5%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 +G G Y V +N T VA+K++ + +REI L++ + HENIV + D+ Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 97 Query: 72 IHTE-----NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 I N + + +E MD DL + + S + L +YF +Q+L+GL + H Sbjct: 98 IPPPLRNAFNDVYIAYELMDTDLHQIIRSN------QALSEEHCQYFLYQILRGLKYIHS 151 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 +LHRDLKP NLL+N LK+ DFGLAR + + VVT WYRAP++L+ S Y Sbjct: 152 ANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSDY 210 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNI 246 + +ID+WS GCI E++ KPLFPG + QL+L+ +++GTP+E + + K I Sbjct: 211 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAK--RYI 268 Query: 247 QQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 +Q PP + + + +D + +L +P R++ AL HP+ + + Sbjct: 269 RQLPPYPRQSITDKF--PTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISD 325 >5Z33-A nrPDB Length = 425 Score = 287 bits (735), Expect = 3e-78, Method: Composition-based stats. Identities = 102/314 (32%), Positives = 162/314 (51%), Gaps = 23/314 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELK- 61 ++ ++LG G Y V +N T VA+K+V + S++ A+REI L++ + Sbjct: 30 DERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRG 89 Query: 62 HENIVRLYDVIHTE----NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 H NI LYD+ N+ L E M+ DL + S + L + F +Q+ Sbjct: 90 HRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRS------GQPLTDAHFQSFIYQI 143 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT----FSSEVVTLW 173 L GL + H +LHRDLKP NLL+N +LK+ DFGLAR F + + V T W Sbjct: 144 LCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRW 203 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 YRAP++++ ++Y+ +ID+WS GCILAE++ G+P F G + +QL I I+GTPNE Sbjct: 204 YRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETL 263 Query: 234 PSV--TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 + + +Y N+ + P + + +D L +L +P R+S +QA Sbjct: 264 SRIGSPRAQEYVRNLPFMAKKPF-----PTLFPNANPDALDLLDRMLAFDPSSRISVEQA 318 Query: 292 LHHPWFAEYYHHAS 305 L HP+ ++ + Sbjct: 319 LEHPYLHIWHDASD 332 >3MIA-A nrPDB Length = 351 Score = 287 bits (734), Expect = 5e-78, Method: Composition-based stats. Identities = 116/307 (37%), Positives = 180/307 (58%), Gaps = 22/307 (7%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHE 63 S++++L K+G GT+ V+K ++ TG VALK+V +++E EG P TA+REI +++ LKHE Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Query: 64 NIVRLYDVIHTE--------NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 N+V L ++ T+ + LVF+F ++DL + N L+ +K Sbjct: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL-----SNVLVKFTLSEIKRVMQ 131 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT----FSSEVVT 171 LL GL + H NKILHRD+K N+LI + G LKL DFGLARAF + N+ +++ VVT Sbjct: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 LWYR P++L+G R Y ID+W GCI+AEM T P+ G ++ QL LI + G+ Sbjct: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 Query: 232 LWPSVTKLPKYNP-NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 +WP+V Y + + R ++ L+ + ++P +D + LL L+P R+ + Sbjct: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPY---ALDLIDKLLVLDPAQRIDSDD 308 Query: 291 ALHHPWF 297 AL+H +F Sbjct: 309 ALNHDFF 315 >4QNY-A nrPDB Length = 354 Score = 287 bits (734), Expect = 5e-78, Method: Composition-based stats. Identities = 93/312 (29%), Positives = 150/312 (48%), Gaps = 21/312 (6%) Query: 4 SSQFKQLEKLGNGTYATVYKGLN-KTTGVYVALKEVKLDSEEGT--PSTAIREISLMKEL 60 ++ +G G+Y V + + K+ VA+K V + E +REI L+ Sbjct: 19 DDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHF 78 Query: 61 KHENIVRLYDVIHTEN-----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 +NI+ L +++ E+ +V + M+ DLK+ + S + L +++F + Sbjct: 79 NDDNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRS------GQELTEAHIQFFIY 132 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 Q L+ L H ++HRD+ P N+L+N LK+ DFGLA+ + V WYR Sbjct: 133 QALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYR 192 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 AP+++M + YS ID+W GCIL E++ +PLF G + QL I D++GTP+E S Sbjct: 193 APELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINS 252 Query: 236 V--TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 V + KY RP D RQ +D L +L NP R++ QA+ Sbjct: 253 VGSSAAQKYLKKKSHRPQADWRQRYP-----TASPEALDLLRHMLVFNPKRRITVLQAMR 307 Query: 294 HPWFAEYYHHAS 305 HP+ + + A Sbjct: 308 HPFLEQLHDDAD 319 >4MVF-A nrPDB Length = 506 Score = 286 bits (733), Expect = 6e-78, Method: Composition-based stats. Identities = 88/299 (29%), Positives = 132/299 (44%), Gaps = 44/299 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 ++ EKLG GTY VYKG++K T A+KE K D + + +EI +MK+L H N Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNI-NRFFQEIEIMKKLDHPN 115 Query: 65 IVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 IV+LY+ +N + L+ E +L + Q+ + + Sbjct: 116 IVKLYETYENDNYIYLIMELCSGRELFDSIIENG------SFTEKNAATIMKQIFSAIFY 169 Query: 124 CHENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 H I+HRDLKP+N L NK LK+ DFGL++ G +++ T +Y AP VL Sbjct: 170 LHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLG-TGEFTTTKAGTPYYVAPQVL 228 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 G Y DIWS G I+ ++ G P F G D E LK + E+ W S+ Sbjct: 229 DG--KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSI---- 282 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + + + LL NP+ R + ++AL+HPW + Sbjct: 283 --------------------------SSDAKNLITKLLTYNPNERCTIEEALNHPWITQ 315 >4MYG-A nrPDB Length = 372 Score = 286 bits (732), Expect = 9e-78, Method: Composition-based stats. Identities = 103/300 (34%), Positives = 156/300 (52%), Gaps = 25/300 (8%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 +G+G Y +V ++K +G VA+K++ + E A RE+ L+K ++HEN++ L DV Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 72 IHTENKL------TLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 + L LV FM DL+K M ++Y +Q+L+GL + H Sbjct: 111 FTPASSLRNFYDFYLVMPFMQTDLQKIMGME--------FSEEKIQYLVYQMLKGLKYIH 162 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 ++HRDLKP NL +N+ +LK+ DFGLAR + VVT WYRAP+V++ Sbjct: 163 SAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE---MTGYVVTRWYRAPEVILSWMH 219 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK--LPKYN 243 Y+ ++DIWS GCI+AEM+TGK LF G + +QL I + G P + Y Sbjct: 220 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 279 Query: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHH 303 ++ Q P +D Q+ D L +L+L+ D RL+A QAL HP+F + Sbjct: 280 QSLPQTPRKDFTQLFPR-----ASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 334 >4ZSG-A nrPDB Length = 347 Score = 286 bits (731), Expect = 1e-77, Method: Composition-based stats. Identities = 101/313 (32%), Positives = 167/313 (53%), Gaps = 24/313 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKH 62 +++ +E +GNG Y V + TG VA+K++ + T +RE+ ++K KH Sbjct: 6 GDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKH 65 Query: 63 ENIVRLYDV------IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 +NI+ + D+ + +V + M++DL + + S + L L V+YF +Q Sbjct: 66 DNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHS------SQPLTLEHVRYFLYQ 119 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIP----VNTFSSEVVTL 172 LL+GL + H +++HRDLKP NLL+N+ +LK+GDFG+AR + V T Sbjct: 120 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 179 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESL 232 WYRAP++++ Y+ +ID+WS GCI EM+ + LFPG N QL+LI ++GTP+ ++ Sbjct: 180 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 239 Query: 233 WPSV--TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 +V ++ Y ++ R P V D + L +L+ P R+SA Sbjct: 240 IQAVGAERVRAYIQSLPPRQPVPWETVYPG-----ADRQALSLLGRMLRFEPSARISAAA 294 Query: 291 ALHHPWFAEYYHH 303 AL HP+ A+Y+ Sbjct: 295 ALRHPFLAKYHDP 307 >3ZDU-A nrPDB Length = 325 Score = 285 bits (730), Expect = 1e-77, Method: Composition-based stats. Identities = 100/296 (33%), Positives = 161/296 (54%), Gaps = 8/296 (2%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 S ++ L K+G G+Y TV K +K TG VA+K E+ A+REI +K+ H Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHH 60 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 EN+V L +V + K+ LVFEF+D+ + + + GLE ++ + +Q+L+ + Sbjct: 61 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQ-----HYCHGLESKRLRKYLFQILRAID 115 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 + H N I+HRD+KP+N+L+++ G KL DFG AR P + + EV T WYRAP++++ Sbjct: 116 YLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLK 175 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 +Y +DIW+ GC++ EM TG P P ++D + L I +G + L +K P + Sbjct: 176 DTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIF 235 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + P+ L+G L D +H LQ++P R+S+ LHH +F Sbjct: 236 AGVVL---PQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFT 288 >3OZ6-A nrPDB Length = 388 Score = 285 bits (729), Expect = 2e-77, Method: Composition-based stats. Identities = 106/336 (31%), Positives = 175/336 (52%), Gaps = 45/336 (13%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELK-HE 63 +++ ++KLG G Y V+K +++ TG VA+K++ + T REI ++ EL HE Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHE 69 Query: 64 NIVRLYDVIHTENK--LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NIV L +V+ +N + LVF++M+ DL + + LE +Y +QL++ + Sbjct: 70 NIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRANI-------LEPVHKQYVVYQLIKVI 122 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF---------------------GI 160 + H +LHRD+KP N+L+N +K+ DFGL+R+F Sbjct: 123 KYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDD 182 Query: 161 PVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKL 220 + V T WYRAP++L+GS Y+ ID+WS GCIL E++ GKP+FPG++ QL+ Sbjct: 183 DQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLER 242 Query: 221 IFDIMGTPNESLWPSVT--------KLPKYNPNIQQRPPRDLRQ-----VLQPHTKEPLD 267 I ++ P+ S+ + K I+Q RD+ +L+ + K + Sbjct: 243 IIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCN 302 Query: 268 GNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHH 303 +D L LLQ NP+ R+SA AL HP+ + +++ Sbjct: 303 EEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNP 338 >5JN2-A nrPDB Length = 525 Score = 283 bits (724), Expect = 7e-77, Method: Composition-based stats. Identities = 86/305 (28%), Positives = 137/305 (44%), Gaps = 45/305 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKELK 61 S ++K LG G++ V +K TG A+K + ++ + +RE+ L+K+L Sbjct: 66 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLD 125 Query: 62 HENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H NI++LY+ + LV E + +L + SR Q+L G Sbjct: 126 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKR------FSEVDAARIIRQVLSG 179 Query: 121 LAFCHENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + + H+NKI+HRDLKP+NLL+ +K +++ DFGL+ F ++ T +Y AP Sbjct: 180 ITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEAS-KKMKDKIGTAYYIAP 238 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +VL G TY D+WS G IL +++G P F G N+ + LK + T W V+ Sbjct: 239 EVLHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVS 296 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + + D + +L P MR+SA+ AL H W Sbjct: 297 E------------------------------SAKDLIRKMLTYVPSMRISARDALDHEWI 326 Query: 298 AEYYH 302 Y Sbjct: 327 QTYTK 331 >5AWM-A nrPDB Length = 394 Score = 281 bits (720), Expect = 2e-76, Method: Composition-based stats. Identities = 96/314 (30%), Positives = 151/314 (48%), Gaps = 26/314 (8%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKHE 63 S++ L +G+G V + T VA+K++ + T A RE LMK + H+ Sbjct: 44 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 103 Query: 64 NIVRLYDVIHTENKL------TLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 NI+ L + + L LV E MD +L + + L+ + + Y +Q+ Sbjct: 104 NIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM--------DLDHDRMSYLLYQM 155 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 L G+ H I+HRDLKP N+++ LK+ DFGLAR G + VVT +YRAP Sbjct: 156 LCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAP 214 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +V++G Y+ ++DIWS GCI+ EMI G LFPGT+ +Q I + +GTP+ S + Sbjct: 215 EVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 273 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLD---------GNLMDFLHGLLQLNPDMRLSA 288 + + R L P P D + + L +L ++P+ R+S Sbjct: 274 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 333 Query: 289 KQALHHPWFAEYYH 302 +AL H + +Y Sbjct: 334 DEALKHEYINVWYD 347 >1JNK-A nrPDB Length = 423 Score = 281 bits (720), Expect = 2e-76, Method: Composition-based stats. Identities = 96/316 (30%), Positives = 150/316 (47%), Gaps = 29/316 (9%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKHEN 64 +++ L+ +G+G V + VA+K++ + T A RE+ LMK + H+N Sbjct: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 Query: 65 IVRLYDVIHTENKL------TLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 I+ L +V + L LV E MD +L + + L+ + Y +Q+L Sbjct: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--------LDHERMSYLLYQML 174 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 G+ H I+HRDLKP N+++ LK+ DFGLAR G + VVT +YRAP+ Sbjct: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPE 233 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 V++G Y ++DIWS GCI+ EM+ K LFPG + +Q + + +GTP + Sbjct: 234 VILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ- 291 Query: 239 LPKYNPNIQQRP-------PRDLRQVLQPHTKEP---LDGNLMDFLHGLLQLNPDMRLSA 288 P ++ RP P+ L P E D L +L ++P R+S Sbjct: 292 -PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 Query: 289 KQALHHPWFAEYYHHA 304 AL HP+ +Y A Sbjct: 351 DDALQHPYINVWYDPA 366 >3E7O-A nrPDB Length = 360 Score = 281 bits (719), Expect = 3e-76, Method: Composition-based stats. Identities = 92/314 (29%), Positives = 154/314 (49%), Gaps = 25/314 (7%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKHEN 64 +++QL+ +G+G V + G+ VA+K++ + T A RE+ L+K + H+N Sbjct: 23 RYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKN 82 Query: 65 IVRLYDVIHTENKL------TLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 I+ L +V + L LV E MD +L + + L+ + Y +Q+L Sbjct: 83 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME--------LDHERMSYLLYQML 134 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 G+ H I+HRDLKP N+++ LK+ DFGLAR + VVT +YRAP+ Sbjct: 135 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNF-MMTPYVVTRYYRAPE 193 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 V++G Y ++DIWS GCI+ E++ G +F GT+ +Q + + +GTP+ ++ Sbjct: 194 VILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQP 252 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGN--------LMDFLHGLLQLNPDMRLSAKQ 290 + + P + L P P + D L +L ++PD R+S + Sbjct: 253 TVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDE 312 Query: 291 ALHHPWFAEYYHHA 304 AL HP+ +Y A Sbjct: 313 ALRHPYITVWYDPA 326 >3HZT-A nrPDB Length = 467 Score = 281 bits (719), Expect = 3e-76, Method: Composition-based stats. Identities = 82/303 (27%), Positives = 141/303 (46%), Gaps = 45/303 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST--AIREISLMKELK 61 S ++++++KLG+G Y V +K TG A+K +K S T ++ + E++++K+L Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD 62 Query: 62 HENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H NI++LY+ + LV E + +L + R + Q+L G Sbjct: 63 HPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILR------QKFSEVDAAVIMKQVLSG 116 Query: 121 LAFCHENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + H++ I+HRDLKP+NLL+ ++ +K+ DFGL+ F + + T +Y AP Sbjct: 117 TTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGK-MKERLGTAYYIAP 175 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +VL + Y D+WSCG IL ++ G P F G D+E LK + + + W V+ Sbjct: 176 EVLR--KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVS 233 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + +L P R+SA++AL+HPW Sbjct: 234 D------------------------------EAKQLVKLMLTYEPSKRISAEEALNHPWI 263 Query: 298 AEY 300 ++ Sbjct: 264 VKF 266 >2XS0-A nrPDB Length = 386 Score = 278 bits (712), Expect = 2e-75, Method: Composition-based stats. Identities = 93/314 (29%), Positives = 148/314 (47%), Gaps = 25/314 (7%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKHEN 64 +++ L+ +G+G V + VA+K++ + T A RE+ LMK + H+N Sbjct: 27 RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 86 Query: 65 IVRLYDVIHTENKL------TLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 I+ L +V + L +V E MD +L + + L+ + Y +Q+L Sbjct: 87 IIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME--------LDHERMSYLLYQML 138 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 G+ H I+HRDLKP N+++ LK+ DFGLAR G VVT +YRAP+ Sbjct: 139 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMVPFVVTRYYRAPE 197 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS--- 235 V++G Y ++DIWS GCI+ EMI G LFPGT+ +Q + + +GTP Sbjct: 198 VILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQP 256 Query: 236 -----VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 V PKY ++ D+ + D L +L ++ R+S + Sbjct: 257 TVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDE 316 Query: 291 ALHHPWFAEYYHHA 304 AL HP+ +Y + Sbjct: 317 ALQHPYINVWYDPS 330 >3DXN-A nrPDB Length = 287 Score = 278 bits (712), Expect = 2e-75, Method: Composition-based stats. Identities = 82/303 (27%), Positives = 141/303 (46%), Gaps = 45/303 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST--AIREISLMKELK 61 S ++++++KLG+G Y V +K TG A+K +K S T ++ + E++++K+L Sbjct: 20 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD 79 Query: 62 HENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H NI++LY+ + LV E + +L + R + Q+L G Sbjct: 80 HPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILR------QKFSEVDAAVIMKQVLSG 133 Query: 121 LAFCHENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + H++ I+HRDLKP+NLL+ ++ +K+ DFGL+ F + + T +Y AP Sbjct: 134 TTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGK-MKERLGTAYYIAP 192 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +VL + Y D+WSCG IL ++ G P F G D+E LK + + + W V+ Sbjct: 193 EVLR--KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVS 250 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + +L P R+SA++AL+HPW Sbjct: 251 D------------------------------EAKQLVKLMLTYEPSKRISAEEALNHPWI 280 Query: 298 AEY 300 ++ Sbjct: 281 VKF 283 >4BGQ-A nrPDB Length = 304 Score = 277 bits (710), Expect = 3e-75, Method: Composition-based stats. Identities = 105/297 (35%), Positives = 166/297 (55%), Gaps = 10/297 (3%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKH 62 ++F+ L +G G Y V K +K T VA+K+ K E E T +RE+ +++ LK Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 ENIV L + KL LVFE+++ ++ + ++ P G+ VK + +QL++ + Sbjct: 71 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLE-----EMPNGVPPEKVKSYIYQLIKAIH 125 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN-TFSSEVVTLWYRAPDVLM 181 +CH+N I+HRD+KP+NLLI+ LKL DFG AR N + EV T WYR+P++L+ Sbjct: 126 WCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLL 185 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 G+ Y S+D+WS GCIL E+ G+PLFPG ++ +QL I ++G P+ Sbjct: 186 GA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPR 244 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + + + P + Q L+ L+ L+D + LL+L+P R +Q L+HP F Sbjct: 245 F--HGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >3LIJ-A nrPDB Length = 494 Score = 277 bits (710), Expect = 3e-75, Method: Composition-based stats. Identities = 85/303 (28%), Positives = 137/303 (45%), Gaps = 44/303 (14%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKEL 60 S +++++KLG+G Y V +K T V A+K ++ S + S + E++++K L Sbjct: 34 HLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLL 93 Query: 61 KHENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H NI++LYD + LV E + +L + R Q+L Sbjct: 94 DHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRM------KFNEVDAAVIIKQVLS 147 Query: 120 GLAFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 G+ + H++ I+HRDLKP+NLL+ K +K+ DFGL+ F + T +Y A Sbjct: 148 GVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFEN-QKKMKERLGTAYYIA 206 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P+VL + Y D+WS G IL ++ G P F G D+E L+ + T + W +V Sbjct: 207 PEVLR--KKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNV 264 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 ++ D + +LQ + R+SA+QAL HPW Sbjct: 265 SE------------------------------GAKDLIKQMLQFDSQRRISAQQALEHPW 294 Query: 297 FAE 299 E Sbjct: 295 IKE 297 >3MA6-A nrPDB Length = 298 Score = 277 bits (708), Expect = 5e-75, Method: Composition-based stats. Identities = 86/305 (28%), Positives = 137/305 (44%), Gaps = 45/305 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKELK 61 S ++K LG G++ V +K TG A+K + ++ + +RE+ L+K+L Sbjct: 31 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLD 90 Query: 62 HENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H NI++LY+ + LV E + +L + SR Q+L G Sbjct: 91 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKR------FSEVDAARIIRQVLSG 144 Query: 121 LAFCHENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + + H+NKI+HRDLKP+NLL+ +K +++ DFGL+ F ++ T +Y AP Sbjct: 145 ITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEAS-KKMKDKIGTAYYIAP 203 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +VL G TY D+WS G IL +++G P F G N+ + LK + T W V+ Sbjct: 204 EVLHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVS 261 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + + D + +L P MR+SA+ AL H W Sbjct: 262 E------------------------------SAKDLIRKMLTYVPSMRISARDALDHEWI 291 Query: 298 AEYYH 302 Y Sbjct: 292 QTYTK 296 >3NCG-A nrPDB Length = 486 Score = 276 bits (706), Expect = 9e-75, Method: Composition-based stats. Identities = 77/302 (25%), Positives = 138/302 (45%), Gaps = 44/302 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE-GTPSTAIREISLMKELKH 62 + ++ + LG G++ V K ++ T A+K + S + ST +RE+ L+K+L H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 63 ENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NI++L++++ + +V E + +L + R + Q+ G+ Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKR------FSEHDAARIIKQVFSGI 134 Query: 122 AFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 + H++ I+HRDLKP+N+L+ K +K+ DFGL+ F + T +Y AP+ Sbjct: 135 TYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQ-NTKMKDRIGTAYYIAPE 193 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL G TY D+WS G IL +++G P F G N+ + LK + + W +++ Sbjct: 194 VLRG--TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISD 251 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + D + +L +P +R++A Q L HPW Sbjct: 252 ------------------------------DAKDLIRKMLTFHPSLRITATQCLEHPWIQ 281 Query: 299 EY 300 +Y Sbjct: 282 KY 283 >2VN9-A nrPDB Length = 301 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 82/309 (26%), Positives = 130/309 (42%), Gaps = 42/309 (13%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKEL 60 S + +++ E+LG G ++ V + + TG A K + RE + + L Sbjct: 1 SMTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLL 60 Query: 61 KHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 KH NIVRL+D I E LVF+ + +L + + +R + Q+L+ Sbjct: 61 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYY------SEADASHCIQQILE 114 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 + CH N I+HRDLKP+NLL+ + + +KL DFGLA + T Y + Sbjct: 115 SVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 174 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P+VL Y +D+W+CG IL ++ G P F + + I W +V Sbjct: 175 PEVLRKD-PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV 233 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 T D ++ +L +NP R++A +AL HPW Sbjct: 234 T------------------------------PEAKDLINKMLTINPAKRITASEALKHPW 263 Query: 297 FAEYYHHAS 305 + AS Sbjct: 264 ICQRSTVAS 272 >5FG8-A nrPDB Length = 285 Score = 275 bits (703), Expect = 2e-74, Method: Composition-based stats. Identities = 83/307 (27%), Positives = 132/307 (42%), Gaps = 42/307 (13%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKH 62 S + E+LG G ++ V + + K+TG A K + RE + ++L H Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHH 72 Query: 63 ENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NIVRL+D I EN LVF+ + +L + + +R + Q+L+ + Sbjct: 73 PNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFY------SEADASHCIQQILESV 126 Query: 122 AFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 CH+N ++HRDLKP+NLL+ + + +KL DFGLA + T Y +P+ Sbjct: 127 NHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPE 186 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL Y S+DIW+CG IL ++ G P F + I W +VT Sbjct: 187 VLK-KEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVT- 244 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + ++ +L +NP+ R++A +AL HPW Sbjct: 245 -----------------------------PEAKNLINQMLTVNPNKRITAAEALKHPWIC 275 Query: 299 EYYHHAS 305 + AS Sbjct: 276 QRERVAS 282 >3FI2-A nrPDB Length = 353 Score = 274 bits (702), Expect = 3e-74, Method: Composition-based stats. Identities = 95/313 (30%), Positives = 149/313 (47%), Gaps = 29/313 (9%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKHEN 64 +++ L+ +G+G V + VA+K++ + T A RE+ LMK + H+N Sbjct: 25 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 84 Query: 65 IVRLYDVIHTENKL------TLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 I+ L +V + L LV E MD +L + + L+ + Y +Q+L Sbjct: 85 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--------LDHERMSYLLYQML 136 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 G+ H I+HRDLKP N+++ LK+ DFGLAR G + VVT +YRAP+ Sbjct: 137 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPE 195 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 V++G Y ++DIWS GCI+ EM+ K LFPG + +Q + + +GTP + Sbjct: 196 VILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ- 253 Query: 239 LPKYNPNIQQRP-------PRDLRQVLQPHTKEP---LDGNLMDFLHGLLQLNPDMRLSA 288 P ++ RP P+ L P E D L +L ++P R+S Sbjct: 254 -PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 312 Query: 289 KQALHHPWFAEYY 301 AL HP+ +Y Sbjct: 313 DDALQHPYINVWY 325 >3DFA-A nrPDB Length = 286 Score = 273 bits (699), Expect = 6e-74, Method: Composition-based stats. Identities = 77/302 (25%), Positives = 138/302 (45%), Gaps = 44/302 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE-GTPSTAIREISLMKELKH 62 + ++ + LG G++ V K ++ T A+K + S + ST +RE+ L+K+L H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 63 ENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NI++L++++ + +V E + +L + R + Q+ G+ Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKR------FSEHDAARIIKQVFSGI 134 Query: 122 AFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 + H++ I+HRDLKP+N+L+ K +K+ DFGL+ F + T +Y AP+ Sbjct: 135 TYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQ-NTKMKDRIGTAYYIAPE 193 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL G TY D+WS G IL +++G P F G N+ + LK + + W +++ Sbjct: 194 VLRG--TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISD 251 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + D + +L +P +R++A Q L HPW Sbjct: 252 ------------------------------DAKDLIRKMLTFHPSLRITATQCLEHPWIQ 281 Query: 299 EY 300 +Y Sbjct: 282 KY 283 >4O2Z-A nrPDB Length = 377 Score = 273 bits (699), Expect = 7e-74, Method: Composition-based stats. Identities = 99/307 (32%), Positives = 159/307 (51%), Gaps = 19/307 (6%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKH 62 S++ L+ LG G Y L+ TG V++K+ + + +REI +M+ H Sbjct: 44 PSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHH 103 Query: 63 ENIVRLYDV-------IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 EN++ + ++ H+ + +V MD D+ + SR V LE + ++YF + Sbjct: 104 ENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQV------LEESHMQYFVY 157 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 Q+L+GL + H + HRDLKP NL+ N +LK+ DFGL+R+ +P + + V+T WYR Sbjct: 158 QILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYR 217 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 P++L+ + YST++DIWS GCI AEM KP+FPG N +QL++I +G P S+ Sbjct: 218 PPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEH 277 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 L K N P + + + +DFL + L+P R +A L HP Sbjct: 278 REALEKLNEL-----PDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHP 332 Query: 296 WFAEYYH 302 + A + Sbjct: 333 YLAHLHD 339 >3COM-A nrPDB Length = 314 Score = 270 bits (691), Expect = 6e-73, Method: Composition-based stats. Identities = 80/292 (27%), Positives = 130/292 (44%), Gaps = 41/292 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F LEKLG G+Y +VYK ++K TG VA+K+V ++S+ I+EIS+M++ ++V Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESD---LQEIIKEISIMQQCDSPHVV 87 Query: 67 RLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 + Y L +V E+ + + R + L + + L+GL + H Sbjct: 88 KYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN-----KTLTEDEIATILQSTLKGLEYLH 142 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 + +HRD+K N+L+N G KL DFG+A + ++ + T ++ AP+V+ Sbjct: 143 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ-EIG 201 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 Y+ DIWS G EM GKP + + + +I Sbjct: 202 YNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMI------------------------ 237 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 PP R+ E N DF+ L +P+ R +A Q L HP+ Sbjct: 238 -PTNPPPTFRK------PELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV 282 >5U6Y-A nrPDB Length = 461 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 77/304 (25%), Positives = 126/304 (41%), Gaps = 42/304 (13%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKHENI 65 ++ E+LG G ++ V + + G A K + RE + + LKH NI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 66 VRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 VRL+D I E L+F+ + +L + + +R + Q+L+ + C Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYY------SEADASHCIQQILEAVLHC 115 Query: 125 HENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 H+ ++HRDLKP+NLL+ + + +KL DFGLA + T Y +P+VL Sbjct: 116 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 175 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 Y +D+W+CG IL ++ G P F + + I W +VT Sbjct: 176 KD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVT---- 230 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 D ++ +L +NP R++A +AL HPW + Sbjct: 231 --------------------------PEAKDLINKMLTINPSKRITAAEALKHPWISHRS 264 Query: 302 HHAS 305 AS Sbjct: 265 TVAS 268 >2V7O-A nrPDB Length = 336 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 80/307 (26%), Positives = 129/307 (42%), Gaps = 42/307 (13%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKH 62 + ++ E+LG G ++ V + + KT A K + RE + + LKH Sbjct: 30 TDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKH 89 Query: 63 ENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NIVRL+D I E LVF+ + +L + + +R + Q+L+ + Sbjct: 90 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYY------SEADASHCIHQILESV 143 Query: 122 AFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 H++ I+HRDLKP+NLL+ + + +KL DFGLA + T Y +P+ Sbjct: 144 NHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPE 203 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL Y +DIW+CG IL ++ G P F + + + I W +VT Sbjct: 204 VLRKD-PYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVT- 261 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + ++ +L +NP R++A QAL HPW Sbjct: 262 -----------------------------PEAKNLINQMLTINPAKRITADQALKHPWVC 292 Query: 299 EYYHHAS 305 + AS Sbjct: 293 QRSTVAS 299 >2BDW-A nrPDB Length = 362 Score = 267 bits (684), Expect = 3e-72, Method: Composition-based stats. Identities = 84/307 (27%), Positives = 131/307 (42%), Gaps = 43/307 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKH 62 S + E+LG G ++ V + ++KTTG+ A K + RE + ++L+H Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH 87 Query: 63 ENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NIVRL+D I E+ LVF+ + +L + + +R + Q+L+ + Sbjct: 88 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFY------SEADASHCIQQILESI 141 Query: 122 AFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 A+CH N I+HR+LKP+NLL+ + + +KL DFGLA + T Y +P+ Sbjct: 142 AYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSPE 200 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL YS +DIW+CG IL ++ G P F + I W +VT Sbjct: 201 VLKKD-PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVT- 258 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + +L +NP R++A QAL PW Sbjct: 259 -----------------------------PEAKSLIDSMLTVNPKKRITADQALKVPWIC 289 Query: 299 EYYHHAS 305 AS Sbjct: 290 NRERVAS 296 >2JC6-A nrPDB Length = 334 Score = 267 bits (683), Expect = 4e-72, Method: Composition-based stats. Identities = 77/296 (26%), Positives = 130/296 (43%), Gaps = 42/296 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F+ E LG G ++ V K TG A+K + + +G S+ EI++++++KHENIV Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 83 Query: 67 RLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 L D+ + N L LV + + L + + Q+L + + H Sbjct: 84 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFY------TEKDASTLIRQVLDAVYYLH 137 Query: 126 ENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 I+HRDLKP+NLL ++ ++ + DFGL++ + S+ T Y AP+VL Sbjct: 138 RMGIVHRDLKPENLLYYSQDEESKIMISDFGLSK-MEGKGDVMSTACGTPGYVAPEVL-A 195 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 + YS ++D WS G I ++ G P F ND + + I + W ++ Sbjct: 196 QKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISD---- 251 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + DF+ L++ +P+ R + +QA HPW A Sbjct: 252 --------------------------SAKDFIRNLMEKDPNKRYTCEQAARHPWIA 281 >3BHH-A nrPDB Length = 295 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 79/309 (25%), Positives = 130/309 (42%), Gaps = 42/309 (13%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKEL 60 S + +++ E +G G ++ V + + TG A K + RE + + L Sbjct: 1 SMTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLL 60 Query: 61 KHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 KH NIVRL+D I E LVF+ + +L + + +R + Q+L+ Sbjct: 61 KHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYY------SEADASHCIQQILE 114 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 + CH+ ++HRDLKP+NLL+ + + +KL DFGLA + T Y + Sbjct: 115 AVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 174 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P+VL Y +DIW+CG IL ++ G P F + + + I W +V Sbjct: 175 PEVLR-KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTV 233 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 T + ++ +L +NP R++A +AL HPW Sbjct: 234 T------------------------------PEAKNLINQMLTINPAKRITAHEALKHPW 263 Query: 297 FAEYYHHAS 305 + AS Sbjct: 264 VCQRSTVAS 272 >2VZ6-A nrPDB Length = 313 Score = 267 bits (682), Expect = 5e-72, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 127/307 (41%), Gaps = 42/307 (13%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKH 62 S ++ E+LG G ++ V + + G A K + RE + + LKH Sbjct: 21 QSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 80 Query: 63 ENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NIVRL+D I E L+F+ + +L + + +R + Q+L+ + Sbjct: 81 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYY------SEADASHCIQQILEAV 134 Query: 122 AFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 CH+ ++HRDLKP+NLL+ + + +KL DFGLA + T Y +P+ Sbjct: 135 LHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPE 194 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL Y +D+W+CG IL ++ G P F + + I W +VT Sbjct: 195 VLRKD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVT- 252 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 D ++ +L +NP R++A +AL HPW + Sbjct: 253 -----------------------------PEAKDLINKMLTINPSKRITAAEALKHPWIS 283 Query: 299 EYYHHAS 305 AS Sbjct: 284 HRSTVAS 290 >4FG9-A nrPDB Length = 320 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 74/296 (25%), Positives = 131/296 (44%), Gaps = 42/296 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 + + LG G ++ V +K T VA+K + ++ EG + EI+++ ++KH NIV Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIV 79 Query: 67 RLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 L D+ + L L+ + + L + + +Q+L + + H Sbjct: 80 ALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFY------TERDASRLIFQVLDAVKYLH 133 Query: 126 ENKILHRDLKPQNLL---INKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 + I+HRDLKP+NLL +++ ++ + DFGL++ P + S+ T Y AP+VL Sbjct: 134 DLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSK-MEDPGSVLSTACGTPGYVAPEVL-A 191 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 + YS ++D WS G I ++ G P F ND + + I + W + Sbjct: 192 QKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDI------ 245 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + DF+ L++ +P+ R + +QAL HPW A Sbjct: 246 ------------------------SDSAKDFIRHLMEKDPEKRFTCEQALQHPWIA 277 >3MN3-A nrPDB Length = 271 Score = 264 bits (676), Expect = 3e-71, Method: Composition-based stats. Identities = 78/296 (26%), Positives = 136/296 (45%), Gaps = 43/296 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKELKH 62 ++ ++ LG G++ V + TTG VALK + ++ REIS ++ L+H Sbjct: 4 GNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRH 63 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 +I++LYDVI +++++ +V E+ N+L Y+ R + + F Q++ + Sbjct: 64 PHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRD------KMSEQEARRFFQQIISAVE 117 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 +CH +KI+HRDLKP+NLL+++ +K+ DFGL+ N + + Y AP+V+ G Sbjct: 118 YCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMT-DGNFLKTSCGSPNYAAPEVISG 176 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 +D+WSCG IL M+ + F + K I + + T LPK+ Sbjct: 177 KLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYT-----------LPKF 225 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 L + +L +NP R+S + + WF Sbjct: 226 -----------------------LSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK 258 >4LG4-A nrPDB Length = 299 Score = 264 bits (676), Expect = 3e-71, Method: Composition-based stats. Identities = 77/293 (26%), Positives = 129/293 (44%), Gaps = 41/293 (13%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F LEKLG G+Y +V+K ++K +G VA+K+V ++S+ I+EIS+M++ +V Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD---LQEIIKEISIMQQCDSPYVV 69 Query: 67 RLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 + Y L +V E+ + + R + L + + L+GL + H Sbjct: 70 KYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN-----KTLIEDEIATILKSTLKGLEYLH 124 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 + +HR++K N+L+N G KL DFG+A + ++ + T ++ AP+V+ Sbjct: 125 FMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ-EIG 183 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 Y+ DIWS G EM GKP + + + +I Sbjct: 184 YNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMI------------------------ 219 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 PP R+ E + DF+ L NP+ R +A Q L HP+ Sbjct: 220 -PTNPPPTFRK------PELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK 265 >3KK8-A nrPDB Length = 284 Score = 264 bits (676), Expect = 3e-71, Method: Composition-based stats. Identities = 84/307 (27%), Positives = 131/307 (42%), Gaps = 43/307 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKH 62 S + E+LG G ++ V + ++KTTG+ A K + RE + ++L+H Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQH 64 Query: 63 ENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NIVRL+D I E+ LVF+ + +L + + +R + Q+L+ + Sbjct: 65 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFY------SEADASHCIQQILESI 118 Query: 122 AFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 A+CH N I+HR+LKP+NLL+ + + +KL DFGLA + T Y +P+ Sbjct: 119 AYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSPE 177 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL YS +DIW+CG IL ++ G P F + I W +VT Sbjct: 178 VLKKD-PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVT- 235 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + +L +NP R++A QAL PW Sbjct: 236 -----------------------------PEAKSLIDSMLTVNPKKRITADQALKVPWIC 266 Query: 299 EYYHHAS 305 AS Sbjct: 267 NRERVAS 273 >5IG1-A nrPDB Length = 344 Score = 264 bits (675), Expect = 4e-71, Method: Composition-based stats. Identities = 81/299 (27%), Positives = 127/299 (42%), Gaps = 43/299 (14%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKHENIVRLYD 70 +G G ++TV++ +NK TG A+K + L S + + REI + L+HE+IV + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRR 83 Query: 71 VIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 E+ LVFE++ L + +R N Q+L L CH I Sbjct: 84 AFRDESHFYLVFEYVSGGELFDEIVTRKFYN------EKDASACMHQILSALQHCHSKNI 137 Query: 130 LHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 +HRDLKP+NLL+ + +K+ DFGLA F T Y +P+V+ Y Sbjct: 138 IHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYF-GFAGTPGYLSPEVIRRV-PY 195 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNI 246 T++D+W+CG IL ++ G P F + ++ I + W SVT K Sbjct: 196 DTAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAK----- 250 Query: 247 QQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 + + +L+ NP R + ++ L HPW A S Sbjct: 251 -------------------------ELIKAMLEPNPKRRPTVQELLQHPWIARRDVPGS 284 >5Y86-A nrPDB Length = 588 Score = 264 bits (674), Expect = 4e-71, Method: Composition-based stats. Identities = 100/328 (30%), Positives = 167/328 (50%), Gaps = 45/328 (13%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE-- 63 +++ L+ +G G++ V + + YVALK V+ +E+ A EI +++ LK + Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKRFHRQAAEEIRILEHLKKQDK 265 Query: 64 ----NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 N++ + + N + + FE + DL + + N +G + LV+ F +LQ Sbjct: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK----NKFQGFSVQLVRKFAQSILQ 321 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 L H+NKI+H DLKP+N+L+ G+ K+ DFG + + + + +YRAP Sbjct: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC---FEYQKLYTYIQSRFYRAP 378 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 ++++GSR YST IDIWS GCILAE++TG+PLFPG ++ +QL + +++G P L + Sbjct: 379 EIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ-S 436 Query: 238 KLPKYNPNIQQRP-------------------PRDLRQVLQPHTKE-------PLDGNLM 271 K KY N + P R ++ P +K+ D + Sbjct: 437 KRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFI 496 Query: 272 DFLHGLLQLNPDMRLSAKQALHHPWFAE 299 +FL L +P RL+ QAL HPW ++ Sbjct: 497 EFLKRCLHWDPSARLTPAQALRHPWISK 524 >5XZW-A nrPDB Length = 471 Score = 264 bits (674), Expect = 5e-71, Method: Composition-based stats. Identities = 84/310 (27%), Positives = 137/310 (44%), Gaps = 53/310 (17%) Query: 6 QFKQL-EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 F + E +G G +ATV K + +TTG A+K + G RE+ ++++L H Sbjct: 196 DFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPR 255 Query: 65 IVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 IVRL +V EF+ DL ++ + + + Q+L + + Sbjct: 256 IVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVG------EDAGREISRQILTAIKY 309 Query: 124 CHENKILHRDLKPQNLLINKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 H I HRDLKP N+LI + +K+ DFGLA+ G + + TL Y AP+V+ Sbjct: 310 IHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGN-GSFMKTFCGTLAYVAPEVIR 368 Query: 182 GSRT------------YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPN 229 G T YS+ +D+WS GC++ ++TG F G+ ++ K I Sbjct: 369 GKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRG----- 423 Query: 230 ESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 + + P +D R + DF+ LLQ++P+ R +A Sbjct: 424 ---------------SYHEGPLKDFR----------ISEEARDFIDSLLQVDPNNRSTAA 458 Query: 290 QALHHPWFAE 299 +AL+HPW + Sbjct: 459 KALNHPWIVD 468 >6AO5-A nrPDB Length = 362 Score = 263 bits (672), Expect = 8e-71, Method: Composition-based stats. Identities = 77/293 (26%), Positives = 129/293 (44%), Gaps = 41/293 (13%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F LEKLG G+Y +V+K ++K +G VA+K+V ++S+ I+EIS+M++ +V Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD---LQEIIKEISIMQQCDSPYVV 68 Query: 67 RLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 + Y L +V E+ + + R + L + + L+GL + H Sbjct: 69 KYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN-----KTLIEDEIATILKSTLKGLEYLH 123 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 + +HR++K N+L+N G KL DFG+A + ++ + T ++ AP+V+ Sbjct: 124 FMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ-EIG 182 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 Y+ DIWS G EM GKP + + + +I Sbjct: 183 YNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMI------------------------ 218 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 PP R+ E + DF+ L NP+ R +A Q L HP+ Sbjct: 219 -PTNPPPTFRK------PELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK 264 >3SOA-A nrPDB Length = 444 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 75/307 (24%), Positives = 127/307 (41%), Gaps = 42/307 (13%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKH 62 + +++ E+LG G ++ V + + G A + RE + + LKH Sbjct: 10 TEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH 69 Query: 63 ENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NIVRL+D I E L+F+ + +L + + +R + Q+L+ + Sbjct: 70 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYY------SEADASHCIQQILEAV 123 Query: 122 AFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 CH+ ++HR+LKP+NLL+ + + +KL DFGLA + T Y +P+ Sbjct: 124 LHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPE 183 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL Y +D+W+CG IL ++ G P F + + I W +VT Sbjct: 184 VLRKD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVT- 241 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 D ++ +L +NP R++A +AL HPW + Sbjct: 242 -----------------------------PEAKDLINKMLTINPSKRITAAEALKHPWIS 272 Query: 299 EYYHHAS 305 AS Sbjct: 273 HRSTVAS 279 >4YZB-A nrPDB Length = 491 Score = 261 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 84/301 (27%), Positives = 134/301 (44%), Gaps = 45/301 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKELK 61 S ++K LG G++ V +K TG A+K + ++ ++E+ L+K+L Sbjct: 29 SDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLD 88 Query: 62 HENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H NI++LY+ + LV E + +L + SR Q+L G Sbjct: 89 HPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKR------FSEVDAARIIRQVLSG 142 Query: 121 LAFCHENKILHRDLKPQNLLINK---RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + + H+NKI+HRDLKP+NLL+ +++ DFGL+ F ++ T +Y AP Sbjct: 143 ITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHF-ESTKKMKDKIGTAYYIAP 201 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +VL G TY D+WS G IL +++G P F G N+ + LK + T + W V+ Sbjct: 202 EVLHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVS 259 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + K D + +L P MR+SA+ AL H W Sbjct: 260 EPAK------------------------------DLIRKMLAYVPTMRISARDALEHEWL 289 Query: 298 A 298 Sbjct: 290 K 290 >4E7W-A nrPDB Length = 394 Score = 261 bits (667), Expect = 3e-70, Method: Composition-based stats. Identities = 99/301 (32%), Positives = 160/301 (53%), Gaps = 21/301 (6%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 + + +GNG++ V++ + VA+K+V D RE+ +M+ +KH N+V Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN-----RELQIMRIVKHPNVV 95 Query: 67 RLYDVIH------TENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 L + E L LV E++ + Y SR + + + L+K + +QLL+ Sbjct: 96 DLKAFFYSNGDKKDEVFLNLVLEYVPETV--YRASRHYAKLKQTMPMLLIKLYMYQLLRS 153 Query: 121 LAFCHENKILHRDLKPQNLLINK-RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 LA+ H I HRD+KPQNLL++ G LKL DFG A+ I S + + +YRAP++ Sbjct: 154 LAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKIL-IAGEPNVSYICSRYYRAPEL 212 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 + G+ Y+T+IDIWS GC++AE++ G+PLFPG + +QL I ++GTP+ ++ Sbjct: 213 IFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTM-NP 271 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 Q P +V +P T + +D + LL+ P RL+A +AL HP+F E Sbjct: 272 NYMEHKFPQIRPHPFSKVFRPRTP----PDAIDLISRLLEYTPSARLTAIEALCHPFFDE 327 Query: 300 Y 300 Sbjct: 328 L 328 >3TAC-A nrPDB Length = 361 Score = 261 bits (667), Expect = 3e-70, Method: Composition-based stats. Identities = 82/306 (26%), Positives = 136/306 (44%), Gaps = 42/306 (13%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP----STAIREISLMKELKH 62 ++ E +G G ++ V + +N+ TG A+K V + +P RE S+ LKH Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +IV L + ++ L +VFEFMD DL + R + + ++ Q+L+ L Sbjct: 88 PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKR--ADAGFVYSEAVASHYMRQILEAL 145 Query: 122 AFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 +CH+N I+HRD+KP +L+ + +KLG FG+A G V T + AP+ Sbjct: 146 RYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPE 205 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 V+ Y +D+W CG IL +++G F GT E + I N W +++ Sbjct: 206 VVK-REPYGKPVDVWGCGVILFILLSGCLPFYGTK-ERLFEGIIKGKYKMNPRQWSHISE 263 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + D + +L L+P R++ +AL+HPW Sbjct: 264 ------------------------------SAKDLVRRMLMLDPAERITVYEALNHPWLK 293 Query: 299 EYYHHA 304 E +A Sbjct: 294 ERDRYA 299 >5ES1-A nrPDB Length = 328 Score = 260 bits (665), Expect = 5e-70, Method: Composition-based stats. Identities = 73/300 (24%), Positives = 124/300 (41%), Gaps = 43/300 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHE 63 ++ L +G G +A V + TG VA+K + K + RE+ +MK L H Sbjct: 15 GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHP 74 Query: 64 NIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 NIV+L++VI TE L LV E+ ++ Y+ S ++ + Q++ + Sbjct: 75 NIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGR------MKEKEARAKFRQIVSAVH 128 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 +CH+ I+HRDLK +NLL++ +K+ DFG + F + + + + Y AP++ G Sbjct: 129 YCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTL-GSKLDTFCGSPPYAAPELFQG 187 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 + +DIWS G IL +++G F G N +E + + Sbjct: 188 KKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKY---------------- 231 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYH 302 + + L L LNP R + +Q + W Y Sbjct: 232 ------------------RVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYE 273 >4RGJ-A nrPDB Length = 520 Score = 259 bits (663), Expect = 9e-70, Method: Composition-based stats. Identities = 84/302 (27%), Positives = 140/302 (46%), Gaps = 46/302 (15%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKELK 61 + Q+K ++ LG G++ V +K TG A+K + K + + +RE+ L+K L Sbjct: 59 NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLD 118 Query: 62 HENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H NI++LY+ N LV + + +L + SR R E++ + Q+L G Sbjct: 119 HINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRK-----RFYEIDAAR-IIKQILSG 172 Query: 121 LAFCHENKILHRDLKPQNLLI----NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 + + H+N ++HRDLKP+N+L+ + +K+ DFGL+ F ++ T +Y A Sbjct: 173 ITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYS-KKMKDKIGTAYYIA 231 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 PDVL G TY DIWSCG IL +++G P F G+N+ + LK + T + + + Sbjct: 232 PDVLHG--TYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKI 289 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 + D + +L +R+SA+ AL H W Sbjct: 290 SD------------------------------KAKDLIKKMLMYTSAVRISARDALEHEW 319 Query: 297 FA 298 Sbjct: 320 IK 321 >3RP9-A nrPDB Length = 458 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 98/362 (27%), Positives = 164/362 (45%), Gaps = 77/362 (21%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKH 62 +++ +G G+Y V + +K VA+K++ E+ +REI+++ L H Sbjct: 52 PDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNH 111 Query: 63 ENIVRLYDVIHTEN-----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 +++V++ D++ ++ +L +V E D+D KK TP L +K + L Sbjct: 112 DHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFR------TPVYLTELHIKTLLYNL 165 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN-------------- 163 L G+ + H ILHRDLKP N L+N+ +K+ DFGLAR P N Sbjct: 166 LVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDM 225 Query: 164 -------------TFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT------ 204 + VVT WYRAP++++ Y+ +ID+WS GCI AE++ Sbjct: 226 NLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENV 285 Query: 205 -----GKPLFPGTN--------------------DEEQLKLIFDIMGTPNESLWPSVTK- 238 PLFPG++ + +QL +IF+I+GTP+E ++ K Sbjct: 286 AYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKE 345 Query: 239 -LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 +Y +R DL + + + L +L NP+ R++ + L HP+F Sbjct: 346 DAKRYIRIFPKREGTDLAERFPAS-----SADAIHLLKRMLVFNPNKRITINECLAHPFF 400 Query: 298 AE 299 E Sbjct: 401 KE 402 >3Q5I-A nrPDB Length = 504 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 75/310 (24%), Positives = 134/310 (43%), Gaps = 55/310 (17%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKL------------DSEEGTPSTAIREI 54 + ++ KLG+G Y V K A+K +K + E EI Sbjct: 38 YFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEI 97 Query: 55 SLMKELKHENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYF 113 SL+K L H NI++L+DV + LV EF + L + + +R + Sbjct: 98 SLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRH------KFDECDAANI 151 Query: 114 QWQLLQGLAFCHENKILHRDLKPQNLLINKRG---QLKLGDFGLARAFGIPVNTFSSEVV 170 Q+L G+ + H++ I+HRD+KP+N+L+ + +K+ DFGL+ F + Sbjct: 152 MKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYK-LRDRLG 210 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNE 230 T +Y AP+VL + Y+ D+WSCG I+ ++ G P F G ND++ +K + + Sbjct: 211 TAYYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDF 268 Query: 231 SLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 + W +++ + + +L + + R +A++ Sbjct: 269 NDWKNISD------------------------------EAKELIKLMLTYDYNKRCTAEE 298 Query: 291 ALHHPWFAEY 300 AL+ W +Y Sbjct: 299 ALNSRWIKKY 308 >6FD3-A nrPDB Length = 300 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 86/300 (28%), Positives = 135/300 (45%), Gaps = 39/300 (13%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 ++ + EK+G G TVY L+ TG VA+K++ L ++ I EI +M+E K+ NI Sbjct: 23 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNL-QQQPKKELIINEILVMRENKNPNI 81 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 V D ++L +V E++ S T T ++ + + LQ L F H Sbjct: 82 VNYLDSYLVGDELWVVMEYLAGG------SLTDVVTETCMDEGQIAAVCRECLQALDFLH 135 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 N+++HRD+K N+L+ G +KL DFG + S+ V T ++ AP+V+ + Sbjct: 136 SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKA 194 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 Y +DIWS G + EM+ G+P + N L LI GTP Sbjct: 195 YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA-TNGTP----------------- 236 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 + E L DFL+ L+++ D R SAK+ L HP+ +S Sbjct: 237 -------------ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLDKPLSS 283 >5YKS-A nrPDB Length = 377 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 86/295 (29%), Positives = 137/295 (46%), Gaps = 43/295 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHENI 65 + + LG G +A V + TG VA+K + K + +E+ MK ++H NI Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 66 VRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 VRLY+VI T+ KL L+ E D D+ Y+ GL +L K + Q++ +++C Sbjct: 97 VRLYEVIDTQTKLYLILELGDGGDMFDYIMKH-----EEGLNEDLAKKYFAQIVHAISYC 151 Query: 125 HENKILHRDLKPQNL-LINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 H+ ++HRDLKP+N+ K+G +KL DFG + F P ++ +L Y AP++L+G Sbjct: 152 HKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQ-PGKKLTTSCGSLAYSAPEILLGD 210 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 + ++DIWS G IL ++ G+P F ND E L +I D T Sbjct: 211 EYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSH------------ 258 Query: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + D + +LQ +P R S ++ +HPW Sbjct: 259 ----------------------VSKECKDLITRMLQRDPKRRASLEEIENHPWLQ 291 >5AIR-A nrPDB Length = 430 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 95/305 (31%), Positives = 152/305 (49%), Gaps = 22/305 (7%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 + + +GNG++ VY+ +G VA+K+V D RE+ +M++L H NIV Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-----RELQIMRKLDHCNIV 120 Query: 67 RLYDVIH------TENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 RL + E L LV +++ + Y +R + L + VK + +QL + Sbjct: 121 RLRYFFYSSGEKKDEVYLNLVLDYVPETV--YRVARHYSRAKQTLPVIYVKLYMYQLFRS 178 Query: 121 LAFCHENKILHRDLKPQNLLINKRG-QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 LA+ H I HRD+KPQNLL++ LKL DFG A+ + S + + +YRAP++ Sbjct: 179 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRAPEL 237 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 + G+ Y++SID+WS GC+LAE++ G+P+FPG + +QL I ++GTP + Sbjct: 238 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN-- 295 Query: 240 PKYNP-NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 P Y Q +V +P T + LL+ P RL+ +A H +F Sbjct: 296 PNYTEFKFPQIKAHPWTKVFRPRTP----PEAIALCSRLLEYTPTARLTPLEACAHSFFD 351 Query: 299 EYYHH 303 E Sbjct: 352 ELRDP 356 >3PG1-A nrPDB Length = 362 Score = 257 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 90/320 (28%), Positives = 153/320 (47%), Gaps = 30/320 (9%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV----------KLDSEEGTPSTAI 51 + S + + +G+Y V G++ + G+ VA+K V + S+ + Sbjct: 19 AMQSPYTVQRFISSGSYGAVCAGVD-SEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVL 77 Query: 52 REISLMKELKHENIVRLYDVIHTENK-----LTLVFEFMDNDLKKYMDSRTVGNTPRGLE 106 REI L+ H NI+ L D+ + L LV E M DL + + + + +P+ Sbjct: 78 REIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQ--- 134 Query: 107 LNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS 166 ++YF + +L GL HE ++HRDL P N+L+ + + DF LAR N + Sbjct: 135 --HIQYFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANK-T 191 Query: 167 SEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMG 226 V WYRAP+++M + ++ +D+WS GC++AEM K LF G+ QL I +++G Sbjct: 192 HYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVG 251 Query: 227 TP---NESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPD 283 TP + ++ S + ++ P R V+ D +D + +L+ NP Sbjct: 252 TPKIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVP-----TADPVALDLIAKMLEFNPQ 306 Query: 284 MRLSAKQALHHPWFAEYYHH 303 R+S +QAL HP+F + Sbjct: 307 RRISTEQALRHPYFESLFDP 326 >3DAK-A nrPDB Length = 290 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 66/305 (21%), Positives = 121/305 (39%), Gaps = 32/305 (10%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 + ++ E +G+G A V VA+K + L+ + + ++EI M + H Sbjct: 8 NRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHH 67 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRG---LELNLVKYFQWQLLQ 119 NIV Y +++L LV + + + V L+ + + ++L+ Sbjct: 68 PNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLE 127 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN-----TFSSEVVTLWY 174 GL + H+N +HRD+K N+L+ + G +++ DFG++ + + V T + Sbjct: 128 GLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCW 187 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 AP+V+ R Y DIWS G E+ TG + + L L Sbjct: 188 MAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLML-------------- 233 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 +Q PP V + + + LQ +P+ R +A + L H Sbjct: 234 ----------TLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRH 283 Query: 295 PWFAE 299 +F + Sbjct: 284 KFFQK 288 >3N9X-A nrPDB Length = 432 Score = 256 bits (654), Expect = 9e-69, Method: Composition-based stats. Identities = 110/354 (31%), Positives = 170/354 (48%), Gaps = 69/354 (19%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKH 62 + +G G+Y VY +K T VA+K+V E+ +REI+++ LK Sbjct: 25 PDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKS 84 Query: 63 ENIVRLYDVIHTEN-----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 + I+RLYD+I ++ +L +V E D+DLKK TP L +K + L Sbjct: 85 DYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFK------TPIFLTEEHIKTILYNL 138 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT------------- 164 L G F HE+ I+HRDLKP N L+N+ +K+ DFGLAR +T Sbjct: 139 LLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPG 198 Query: 165 ---------FSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMI-----------T 204 +S VVT WYRAP++++ Y+ SIDIWS GCI AE++ Sbjct: 199 PHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTN 258 Query: 205 GKPLFPGT-----------------NDEEQLKLIFDIMGTPNESLWPSV--TKLPKYNPN 245 PLFPG+ ++ +QL +IF+I+GTP E ++ ++ KY Sbjct: 259 RFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKL 318 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 R P +L+Q + + ++ L +L+ NP+ R++ QAL HP+ + Sbjct: 319 FPHRKPINLKQKYPS-----ISDDGINLLESMLKFNPNKRITIDQALDHPYLKD 367 >2QNJ-A nrPDB Length = 328 Score = 255 bits (653), Expect = 1e-68, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 129/300 (43%), Gaps = 43/300 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHE 63 ++ L+ +G G +A V + TG VA+K + K + RE+ +MK L H Sbjct: 12 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 71 Query: 64 NIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 NIV+L++VI TE L L+ E+ + Y+ + ++ + Q++ + Sbjct: 72 NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR------MKEKEARSKFRQIVSAVQ 125 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 +CH+ +I+HRDLK +NLL++ +K+ DFG + F + + + Y AP++ G Sbjct: 126 YCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGK-LDTFCGSPPYAAPELFQG 184 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 + +D+WS G IL +++G F G N +E + + ++P Y Sbjct: 185 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY-----------RIPFY 233 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYH 302 + + + L L LNP R + +Q + W + Sbjct: 234 -----------------------MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHE 270 >3H4J-B nrPDB Length = 336 Score = 255 bits (652), Expect = 1e-68, Method: Composition-based stats. Identities = 72/293 (24%), Positives = 124/293 (42%), Gaps = 43/293 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKELKHEN 64 + E LG G++ V + T VALK + + REIS +K L+H + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 I++LYDVI T + +V E+ +L Y+ + + + + F Q++ + +C Sbjct: 71 IIKLYDVITTPTDIVMVIEYAGGELFDYIVEKKR------MTEDEGRRFFQQIICAIEYC 124 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 H +KI+HRDLKP+NLL++ +K+ DFGL+ N + + Y AP+V+ G Sbjct: 125 HRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMT-DGNFLKTSCGSPNYAAPEVINGKL 183 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 +D+WSCG +L M+ G+ F +L+ V P Sbjct: 184 YAGPEVDVWSCGIVLYVMLVGRLPFDDE---------------FIPNLFKKVNSCVYVMP 228 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + L + ++ +P R++ ++ PWF Sbjct: 229 DF-------------------LSPGAQSLIRRMIVADPMQRITIQEIRRDPWF 262 >5KZ7-A nrPDB Length = 346 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 73/301 (24%), Positives = 128/301 (42%), Gaps = 43/301 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHE 63 ++ L+ +G G +A V + TG VA+K + K + RE+ +MK L H Sbjct: 33 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 92 Query: 64 NIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 NIV+L++VI TE L LV E+ + Y+ + ++ + Q++ + Sbjct: 93 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR------MKEKEARAKFRQIVSAVQ 146 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 +CH+ I+HRDLK +NLL++ +K+ DFG + F N + + Y AP++ G Sbjct: 147 YCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTF-GNKLDTFCGSPPYAAPELFQG 205 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 + +D+WS G IL +++G F G N +E + + ++P Y Sbjct: 206 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY-----------RIPFY 254 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYH 302 + + + L L LNP R + +Q + W + Sbjct: 255 -----------------------MSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHE 291 Query: 303 H 303 Sbjct: 292 D 292 >4PDS-A nrPDB Length = 347 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 82/309 (26%), Positives = 135/309 (43%), Gaps = 53/309 (17%) Query: 6 QFKQL-EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 F + E +G G +ATV K + +TTG ++K + G RE+ ++++L H Sbjct: 31 DFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPR 90 Query: 65 IVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 IVRL +V EF+ DL ++ + + + Q+L + + Sbjct: 91 IVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVG------EDAGREISRQILTAIKY 144 Query: 124 CHENKILHRDLKPQNLLINKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 H I HRDLKP N+LI + +K+ FGLA+ G + + TL Y AP+V+ Sbjct: 145 IHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGN-GSFMKTFCGTLAYVAPEVIR 203 Query: 182 GSRT------------YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPN 229 G T YS+ +D+WS GC++ ++TG F G+ ++ K I Sbjct: 204 GKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRG----- 258 Query: 230 ESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 + + P +D R + DF+ LLQ++P+ R +A Sbjct: 259 ---------------SYHEGPLKDFR----------ISEEARDFIDSLLQVDPNNRSTAA 293 Query: 290 QALHHPWFA 298 +AL+HPW Sbjct: 294 KALNHPWIK 302 >2UV2-A nrPDB Length = 325 Score = 254 bits (649), Expect = 3e-68, Method: Composition-based stats. Identities = 86/301 (28%), Positives = 123/301 (40%), Gaps = 41/301 (13%) Query: 3 SSSQF-KQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 + F + + +LG+G + VYK NK T V A K + SEE + EI ++ Sbjct: 34 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEE-ELEDYMVEIDILASCD 92 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H NIV+L D + EN L ++ EF + R L + ++ Q L L Sbjct: 93 HPNIVKLLDAFYYENNLWILIEFCAGGAVD----AVMLELERPLTESQIQVVCKQTLDAL 148 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 + H+NKI+HRDLK N+L G +KL DFG++ + S + T ++ AP+V+M Sbjct: 149 NYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVM 208 Query: 182 ----GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 R Y D+WS G L EM +P N L I Sbjct: 209 CETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKI---------------- 252 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 K P +P R N DFL L+ N D R + Q L HP+ Sbjct: 253 --AKSEPPTLAQPSR-------------WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 297 Query: 298 A 298 Sbjct: 298 T 298 >2XIK-A nrPDB Length = 294 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 74/299 (24%), Positives = 127/299 (42%), Gaps = 40/299 (13%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F +L+++G G++ VYKG++ T VA+K + L+ E +EI+++ + I Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 80 Query: 67 RLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 R + KL ++ E++ S P LE + ++L+GL + H Sbjct: 81 RYFGSYLKSTKLWIIMEYLGGG------SALDLLKPGPLEETYIATILREILKGLDYLHS 134 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 + +HRD+K N+L++++G +KL DFG+A ++ V T ++ AP+V+ S Y Sbjct: 135 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AY 193 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNI 246 DIWS G E+ G+P + L LI PK +P Sbjct: 194 DFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLI------------------PKNSP-- 233 Query: 247 QQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 P + +F+ L +P R +AK+ L H + Y S Sbjct: 234 -------------PTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTS 279 >4FIE-A nrPDB Length = 423 Score = 254 bits (648), Expect = 4e-68, Method: Composition-based stats. Identities = 74/294 (25%), Positives = 135/294 (45%), Gaps = 39/294 (13%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 K+G G+ V +++G VA+K++ L ++ E+ +M++ +HEN+V +Y+ Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR-RELLFNEVVIMRDYQHENVVEMYNS 216 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 ++L +V EF++ + + T N + +LQ L+ H ++H Sbjct: 217 YLVGDELWVVMEFLEGGALTDIVTHTRMN------EEQIAAVCLAVLQALSVLHAQGVIH 270 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSID 191 RD+K ++L+ G++KL DFG V S V T ++ AP+++ Y +D Sbjct: 271 RDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVD 329 Query: 192 IWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPP 251 IWS G ++ EM+ G+P + + +K+I D +L P + L K +P+++ Sbjct: 330 IWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-------NLPPRLKNLHKVSPSLKG--- 379 Query: 252 RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 FL LL +P R +A + L HP+ A+ AS Sbjct: 380 ---------------------FLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 412 >3D2K-A nrPDB Length = 272 Score = 254 bits (648), Expect = 5e-68, Method: Composition-based stats. Identities = 69/297 (23%), Positives = 120/297 (40%), Gaps = 46/297 (15%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE--GTPSTAIREISLMKELKH 62 F LG G + VY + + +ALK + E G RE+ + L+H Sbjct: 12 EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRH 71 Query: 63 ENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NI+RLY H ++ L+ E+ + + + + + + +L L Sbjct: 72 PNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSR------FDEQRTATYITELANAL 125 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 ++CH +++HRD+KP+NLL+ G+LK+ DFG + P + ++ TL Y P+++ Sbjct: 126 SYCHSKRVIHRDIKPENLLLGSNGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIE 183 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 G R + +D+WS G + E + G P F +E + I + T + Sbjct: 184 G-RMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDF---------- 232 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + D + LL+ N RL+ + L HPW Sbjct: 233 ------------------------VTEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >4UZD-A nrPDB Length = 287 Score = 253 bits (647), Expect = 6e-68, Method: Composition-based stats. Identities = 72/299 (24%), Positives = 123/299 (41%), Gaps = 46/299 (15%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE--GTPSTAIREISLMKEL 60 + F+ LG G + VY K + +ALK + E G RE+ + L Sbjct: 6 ALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHL 65 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 +H NI+RLY H ++ L+ E+ + + + + + + +L Sbjct: 66 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS------KFDEQRTATYITELAN 119 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 L++CH +++HRD+KP+NLL+ G+LK+ DFG + P + ++ TL Y P++ Sbjct: 120 ALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEM 177 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 + G R + +D+WS G + E + GKP F +E K I + T + Sbjct: 178 IEG-RMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDF-------- 228 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + D + LL+ NP R ++ L HPW Sbjct: 229 --------------------------VTEGARDLISRLLKHNPSQRPMLREVLEHPWIT 261 >4QMW-A nrPDB Length = 310 Score = 253 bits (647), Expect = 6e-68, Method: Composition-based stats. Identities = 74/291 (25%), Positives = 128/291 (43%), Gaps = 40/291 (13%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F +LEK+G G++ V+KG++ T VA+K + L+ E +EI+++ + + Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 90 Query: 67 RLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 + Y + KL ++ E++ S P L+ + ++L+GL + H Sbjct: 91 KYYGSYLKDTKLWIIMEYLGGG------SALDLLEPGPLDETQIATILREILKGLDYLHS 144 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 K +HRD+K N+L+++ G++KL DFG+A ++ V T ++ AP+V+ S Y Sbjct: 145 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AY 203 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNI 246 + DIWS G E+ G+P + + L LI PK NP Sbjct: 204 DSKADIWSLGITAIELARGEPPHSELHPMKVLFLI------------------PKNNP-- 243 Query: 247 QQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 P + L +F+ L P R +AK+ L H + Sbjct: 244 -------------PTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 281 >4REW-A nrPDB Length = 540 Score = 253 bits (647), Expect = 6e-68, Method: Composition-based stats. Identities = 76/298 (25%), Positives = 123/298 (41%), Gaps = 44/298 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE--GTPSTAIREISLMKELKH 62 + + LG GT+ V G ++ TG VA+K + REI +K +H Sbjct: 6 GHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH 65 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +I++LY VI T + + +V E++ L Y+ L+ + Q+L G+ Sbjct: 66 PHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR------LDEKESRRLFQQILSGV 119 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 +CH + ++HRDLKP+N+L++ K+ DFGL+ + + Y AP+V+ Sbjct: 120 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVIS 178 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 G +DIWS G IL ++ G F + K I D + + L PSV Sbjct: 179 GRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV----- 233 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + L +LQ++P R S K H WF + Sbjct: 234 -----------------------------ISLLKHMLQVDPMKRASIKDIREHEWFKQ 262 >3E3P-A nrPDB Length = 360 Score = 253 bits (647), Expect = 6e-68, Method: Composition-based stats. Identities = 97/315 (30%), Positives = 158/315 (50%), Gaps = 23/315 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL--- 60 +F+ G GT+ TV G K+TG+ VA+K+V D P RE+ +M++L Sbjct: 22 MDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQD-----PRFRNRELQIMQDLAVL 76 Query: 61 KHENIVRLYDVIHTENK-------LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYF 113 H NIV+L +T + L +V E++ + L + R L+K F Sbjct: 77 HHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCC--RNYYRRQVAPPPILIKVF 134 Query: 114 QWQLLQGLAFCH--ENKILHRDLKPQNLLINK-RGQLKLGDFGLARAFGIPVNTFSSEVV 170 +QL++ + H + HRD+KP N+L+N+ G LKL DFG A+ P + + Sbjct: 135 LFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLS-PSEPNVAYIC 193 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNE 230 + +YRAP+++ G++ Y+T++DIWS GCI AEM+ G+P+F G N QL I ++G P+ Sbjct: 194 SRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSR 253 Query: 231 SLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 + + + ++ V H+ + D L LLQ P+ R+ + Sbjct: 254 EVLRKL-NPSHTDVDLYNSKGIPWSNVFSDHSLKD-AKEAYDLLSALLQYLPEERMKPYE 311 Query: 291 ALHHPWFAEYYHHAS 305 AL HP+F E + A+ Sbjct: 312 ALCHPYFDELHDPAT 326 >2J90-A nrPDB Length = 304 Score = 253 bits (646), Expect = 8e-68, Method: Composition-based stats. Identities = 72/309 (23%), Positives = 130/309 (42%), Gaps = 48/309 (15%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-----STAIREISLMKE 59 ++ E+LG+G +A V K K TG A K +K + RE+++++E Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 85 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 ++H NI+ L+D+ + + L+ E + L ++ + L + F Q+L Sbjct: 86 IRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEK------ESLTEDEATQFLKQIL 139 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRG----QLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 G+ + H +I H DLKP+N+++ + ++KL DFG+A N F + T + Sbjct: 140 DGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEA-GNEFKNIFGTPEF 198 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 AP+++ D+WS G I +++G F G +E L I + +E + Sbjct: 199 VAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFS 257 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 + ++L K DF+ LL +P R++ Q+L H Sbjct: 258 NTSELAK------------------------------DFIRRLLVKDPKRRMTIAQSLEH 287 Query: 295 PWFAEYYHH 303 W Sbjct: 288 SWIKAIRRR 296 >2I6L-A nrPDB Length = 320 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 102/316 (32%), Positives = 165/316 (52%), Gaps = 32/316 (10%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 S++ L+ LG G V+ ++ VA+K++ L + A+REI +++ L H+ Sbjct: 10 GSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKH-ALREIKIIRRLDHD 68 Query: 64 NIVRLY--------------DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNL 109 NIV+++ + N + +V E+M+ DL ++ L Sbjct: 69 NIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQG-------PLLEEH 121 Query: 110 VKYFQWQLLQGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNT---F 165 + F +QLL+GL + H +LHRDLKP NL IN + LK+GDFGLAR + Sbjct: 122 ARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHL 181 Query: 166 SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIM 225 S +VT WYR+P +L+ Y+ +ID+W+ GCI AEM+TGK LF G ++ EQ++LI + + Sbjct: 182 SEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESI 241 Query: 226 GTPNESLWPS-VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDM 284 +E ++ +P Y N P + L Q+L + +DFL +L +P Sbjct: 242 PVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPG-----ISREAVDFLEQILTFSPMD 296 Query: 285 RLSAKQALHHPWFAEY 300 RL+A++AL HP+ + Y Sbjct: 297 RLTAEEALSHPYMSIY 312 >5WAX-A nrPDB Length = 310 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 71/302 (23%), Positives = 126/302 (41%), Gaps = 40/302 (13%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 M +++ + +G+G + N+ G VA+K + + E REI + L Sbjct: 7 MHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYI--ERGEKIDENVQREIINHRSL 64 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +H NI+R +VI T L +V E+ + + ++F QL+ G Sbjct: 65 RHPNIIRFKEVILTPTHLAIVMEYASGG-----ELFERICNAGRFSEDEARFFFQQLISG 119 Query: 121 LAFCHENKILHRDLKPQNLLINKRG--QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 +++CH ++ HRDLK +N L++ +LK+ DFG +++ + + S V T Y AP+ Sbjct: 120 VSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPE 178 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKL-IFDIMGTPNESLWPSVT 237 VL+ D+WSCG L M+ G F ++ + + I I+G Sbjct: 179 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV--------QY 230 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 +P Y + D + + NP R++ + +HPWF Sbjct: 231 SIPDYV---------------------HISPECQDLISRIFVANPATRITIPEIRNHPWF 269 Query: 298 AE 299 + Sbjct: 270 LK 271 >4CFF-A nrPDB Length = 571 Score = 252 bits (644), Expect = 1e-67, Method: Composition-based stats. Identities = 74/298 (24%), Positives = 118/298 (39%), Gaps = 44/298 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE--GTPSTAIREISLMKELKH 62 + + LG GT+ V G ++ TG VA+K + REI +K +H Sbjct: 33 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 92 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +I++LY VI T +V E++ L Y+ +E + Q+L + Sbjct: 93 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR------VEEMEARRLFQQILSAV 146 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 +CH + ++HRDLKP+N+L++ K+ DFGL+ + + Y AP+V+ Sbjct: 147 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVIS 205 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 G +DIWSCG IL ++ G F + K I + E L SV Sbjct: 206 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT--- 262 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 L +LQ++P R + K H WF + Sbjct: 263 -------------------------------LLMHMLQVDPLKRATIKDIREHEWFKQ 289 >3NIE-A nrPDB Length = 429 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 107/355 (30%), Positives = 167/355 (47%), Gaps = 68/355 (19%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-STAIREISLMKELKH 62 ++ +G G+Y VY +K VA+K+V E+ +REI+++ LK Sbjct: 27 PDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKS 86 Query: 63 ENIVRLYDVIHTEN-----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 + I+RL+D+I E+ +L +V E D+DLKK TP L VK + L Sbjct: 87 DYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFK------TPIFLTEQHVKTILYNL 140 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN-------------- 163 L G F HE+ I+HRDLKP N L+N+ +K+ DFGLAR + Sbjct: 141 LLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENE 200 Query: 164 -----------TFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMI--------- 203 +S VVT WYRAP++++ Y+ SIDIWS GCI AE++ Sbjct: 201 EPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINN 260 Query: 204 --TGKPLFPGT-----------------NDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 PLFPG+ ++ +QL +IF+++GTP E +TK + Sbjct: 261 PTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITK-QEVIK 319 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 I+ P RD + + ++ + +D L +L+ N R++ +AL HP+ + Sbjct: 320 YIKLFPTRDGIDLSKKYSS--ISKEGIDLLESMLRFNAQKRITIDKALSHPYLKD 372 >5DBX-A nrPDB Length = 328 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 71/308 (23%), Positives = 124/308 (40%), Gaps = 34/308 (11%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 ++ E +G+G A V L K VA+K + L+ + + ++EI M + H N Sbjct: 11 DAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPN 70 Query: 65 IVRLYDVIHTENKLTLVFEFMDN----DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +V Y +++L LV + + D+ KY+ +R LE ++ ++L+G Sbjct: 71 VVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGV-LEEAIIATILKEVLEG 129 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN-----TFSSEVVTLWYR 175 L + H N +HRDLK N+L+ + G +++ DFG++ + V T + Sbjct: 130 LDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWM 189 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 AP+V+ R Y D+WS G E+ TG + + L L Sbjct: 190 APEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLML--------------- 234 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 +Q PP V + + L LQ +P R +A + L Sbjct: 235 ---------TLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCK 285 Query: 296 WFAEYYHH 303 +F + + Sbjct: 286 FFQKAKNR 293 >4JDH-A nrPDB Length = 346 Score = 251 bits (642), Expect = 2e-67, Method: Composition-based stats. Identities = 74/294 (25%), Positives = 135/294 (45%), Gaps = 39/294 (13%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 K+G G+ V +++G VA+K++ L ++ E+ +M++ +HEN+V +Y+ Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR-RELLFNEVVIMRDYQHENVVEMYNS 139 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 ++L +V EF++ + + T N + +LQ L+ H ++H Sbjct: 140 YLVGDELWVVMEFLEGGALTDIVTHTRMN------EEQIAAVCLAVLQALSVLHAQGVIH 193 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSID 191 RD+K ++L+ G++KL DFG V S V T ++ AP+++ Y +D Sbjct: 194 RDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVD 252 Query: 192 IWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPP 251 IWS G ++ EM+ G+P + + +K+I D +L P + L K +P+++ Sbjct: 253 IWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-------NLPPRLKNLHKVSPSLKG--- 302 Query: 252 RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 FL LL +P R +A + L HP+ A+ AS Sbjct: 303 ---------------------FLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 335 >5EZV-A nrPDB Length = 560 Score = 251 bits (642), Expect = 2e-67, Method: Composition-based stats. Identities = 74/298 (24%), Positives = 118/298 (39%), Gaps = 44/298 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE--GTPSTAIREISLMKELKH 62 + + LG GT+ V G ++ TG VA+K + REI +K +H Sbjct: 28 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 87 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +I++LY VI T +V E++ L Y+ +E + Q+L + Sbjct: 88 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR------VEEMEARRLFQQILSAV 141 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 +CH + ++HRDLKP+N+L++ K+ DFGL+ + + Y AP+V+ Sbjct: 142 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVIS 200 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 G +DIWSCG IL ++ G F + K I + E L SV Sbjct: 201 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT--- 257 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 L +LQ++P R + K H WF + Sbjct: 258 -------------------------------LLMHMLQVDPLKRATIKDIREHEWFKQ 284 >4CZT-A nrPDB Length = 464 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 126/303 (41%), Gaps = 45/303 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKH 62 +++ LG GT+A V N G VA+K + + + + REIS MK +KH Sbjct: 11 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 70 Query: 63 ENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 N++R+++V+ ++ K+ V EF+ +L + S L+ + + + QL+ + Sbjct: 71 PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR------LKEDEARKYFQQLINAV 124 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGI--PVNTFSSEVVTLWYRAPDV 179 +CH + HRDLKP+NLL++ G LK+ DFGL+ + T Y AP+V Sbjct: 125 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 184 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 + D+WSCG IL ++ G F +N K IF T Sbjct: 185 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPW-------- 236 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + + +L NP R++ + + + WF + Sbjct: 237 --------------------------FSASAKKLIKRILDPNPATRITFAEVIENEWFKK 270 Query: 300 YYH 302 Y Sbjct: 271 GYK 273 >4XBR-A nrPDB Length = 366 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 74/294 (25%), Positives = 135/294 (45%), Gaps = 39/294 (13%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 K+G G+ V +++G VA+K++ L ++ E+ +M++ +HEN+V +Y+ Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR-RELLFNEVVIMRDYQHENVVEMYNS 159 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 ++L +V EF++ + + T N + +LQ L+ H ++H Sbjct: 160 YLVGDELWVVMEFLEGGALTDIVTHTRMN------EEQIAAVCLAVLQALSVLHAQGVIH 213 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSID 191 RD+K ++L+ G++KL DFG V S V T ++ AP+++ Y +D Sbjct: 214 RDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVD 272 Query: 192 IWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPP 251 IWS G ++ EM+ G+P + + +K+I D +L P + L K +P+++ Sbjct: 273 IWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-------NLPPRLKNLHKVSPSLKG--- 322 Query: 252 RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 FL LL +P R +A + L HP+ A+ AS Sbjct: 323 ---------------------FLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 355 >2Q0N-A nrPDB Length = 301 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 74/294 (25%), Positives = 135/294 (45%), Gaps = 39/294 (13%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 K+G G+ V +++G VA+K++ L ++ E+ +M++ +HEN+V +Y+ Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR-RELLFNEVVIMRDYQHENVVEMYNS 94 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 ++L +V EF++ + + T N + +LQ L+ H ++H Sbjct: 95 YLVGDELWVVMEFLEGGALTDIVTHTRMN------EEQIAAVCLAVLQALSVLHAQGVIH 148 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSID 191 RD+K ++L+ G++KL DFG V S V T ++ AP+++ Y +D Sbjct: 149 RDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVD 207 Query: 192 IWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPP 251 IWS G ++ EM+ G+P + + +K+I D +L P + L K +P+++ Sbjct: 208 IWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD-------NLPPRLKNLHKVSPSLKG--- 257 Query: 252 RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 FL LL +P R +A + L HP+ A+ AS Sbjct: 258 ---------------------FLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 290 >5KCV-A nrPDB Length = 460 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 132/304 (43%), Gaps = 48/304 (15%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKEL 60 + ++F+ L+ LG GT+ V K TG Y A+K +K + + + + E +++ Sbjct: 160 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 219 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +H + L T ++L V E+ + + SR R + +++ +++ Sbjct: 220 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR-----ERVFSEDRARFYGAEIVSA 274 Query: 121 LAFCHE-NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 L + H +++RDLK +NL+++K G +K+ DFGL + T + T Y AP+V Sbjct: 275 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 334 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 L + Y ++D W G ++ EM+ G+ F + E+ +LI Sbjct: 335 LEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL----------------- 376 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALHH 294 + ++ P T P L GLL+ +P RL AK+ + H Sbjct: 377 --------------MEEIRFPRTLGP---EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 419 Query: 295 PWFA 298 +FA Sbjct: 420 RFFA 423 >3IS5-A nrPDB Length = 285 Score = 250 bits (640), Expect = 4e-67, Method: Composition-based stats. Identities = 77/297 (25%), Positives = 130/297 (43%), Gaps = 40/297 (13%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F KLG+G + V+ +++G+ +K + D + EI ++K L H NI+ Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHPNII 83 Query: 67 RLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 ++++V + + +V E + L + + S + L V Q++ LA+ H Sbjct: 84 KIFEVFEDYHNMYIVMETCEGGELLERIVSAQA--RGKALSEGYVAELMKQMMNALAYFH 141 Query: 126 ENKILHRDLKPQNLLINK---RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 ++H+DLKP+N+L +K+ DFGLA F ++ ++ T Y AP+V Sbjct: 142 SQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHS-TNAAGTALYMAPEVF-- 198 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 R + DIWS G ++ ++TG F GT+ EE + + K P Y Sbjct: 199 KRDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQK--------------ATYKEPNY 244 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + PL +D L +L +P+ R SA Q LHH WF + Sbjct: 245 AVECR-----------------PLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >2JAM-A nrPDB Length = 304 Score = 250 bits (639), Expect = 5e-67, Method: Composition-based stats. Identities = 79/295 (26%), Positives = 131/295 (44%), Gaps = 44/295 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F +E LG+G ++ V+ + TG ALK +K S S+ EI+++K++KHENIV Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIK-KSPAFRDSSLENEIAVLKKIKHENIV 69 Query: 67 RLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 L D+ + LV + + L + R V Q+L + + H Sbjct: 70 TLEDIYESTTHYYLVMQLVSGGELFDRILERGVY------TEKDASLVIQQVLSAVKYLH 123 Query: 126 ENKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 EN I+HRDLKP+NLL + ++ + DFGL++ + S+ T Y AP+VL Sbjct: 124 ENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGI--MSTACGTPGYVAPEVL-A 180 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 + YS ++D WS G I ++ G P F + + + I + W +++ Sbjct: 181 QKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISE---- 236 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + DF+ LL+ +P+ R + ++AL HPW Sbjct: 237 --------------------------SAKDFICHLLEKDPNERYTCEKALSHPWI 265 >5J5T-A nrPDB Length = 370 Score = 249 bits (637), Expect = 9e-67, Method: Composition-based stats. Identities = 72/301 (23%), Positives = 124/301 (41%), Gaps = 37/301 (12%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 S F+ ++++G+GTY VYK N TG A+K +KL+ E + +EI +MK+ K Sbjct: 1 GSQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDF-AVVQQEIIMMKDCK 59 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H NIV + +KL + EF + + + L + Y + LQGL Sbjct: 60 HPNIVAYFGSYLRRDKLWICMEFCGGG-----SLQDIYHVTGPLSELQIAYVSRETLQGL 114 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV-- 179 + H +HRD+K N+L+ G +KL DFG++ + + + T ++ AP+V Sbjct: 115 YYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAA 174 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 + Y+ D+W+ G E+ +P + L L+ P + Sbjct: 175 VERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKL-------- 226 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 K + F+ L NP R +A++ L HP+ + Sbjct: 227 ---------------------KDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQ 265 Query: 300 Y 300 + Sbjct: 266 H 266 >3F3Z-A nrPDB Length = 277 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 79/296 (26%), Positives = 118/296 (39%), Gaps = 42/296 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 + +G G++ V + K T + A K++ E +EI +MK L H NI+ Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDR-FKQEIEIMKSLDHPNII 69 Query: 67 RLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 RLY+ + LV E + R V R + +L +A+CH+ Sbjct: 70 RLYETFEDNTDIYLVMELCTGG---ELFERVVHK--RVFRESDAARIMKDVLSAVAYCHK 124 Query: 127 NKILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 + HRDLKP+N L + LKL DFGLA F P ++V T +Y +P VL G Sbjct: 125 LNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFK-PGKMMRTKVGTPYYVSPQVLEG- 182 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 Y D WS G ++ ++ G P F D E + I + T E W +V Sbjct: 183 -LYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNV------- 234 Query: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + LL +P R+++ QAL H WF + Sbjct: 235 -----------------------SPQAESLIRRLLTKSPKQRITSLQALEHEWFEK 267 >4CQG-A nrPDB Length = 331 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 79/297 (26%), Positives = 130/297 (43%), Gaps = 42/297 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 ++ E +G G +A V + TG VA+K + ++ EI +K L+H++I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHIC 70 Query: 67 RLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 +LY V+ T+NK+ +V E+ L Y+ S+ L + Q+L +A+ H Sbjct: 71 QLYHVLETKNKIFMVLEYCPGGELFDYIISQDR------LSEEETRVVFRQILSAVAYVH 124 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGL-ARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 HRDLKP+NLL ++ +LKL DFGL A+ G +L Y AP+++ G Sbjct: 125 SQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKS 184 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 + D+WS G +L ++ G F N K I ++PK+ Sbjct: 185 YLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKY-----------EVPKW-- 231 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 L + + L +LQ++P R+S + L+HPW + Y Sbjct: 232 ---------------------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDY 267 >3GUB-A nrPDB Length = 295 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 72/305 (23%), Positives = 131/305 (42%), Gaps = 48/305 (15%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-----STAIREISLMK 58 + E+LG+G +A V K K+TG+ A K +K + + RE+S++K Sbjct: 10 DDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILK 69 Query: 59 ELKHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 E++H N++ L++V + + L+ E + +L ++ + L F Q+ Sbjct: 70 EIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEK------ESLTEEEATEFLKQI 123 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRG----QLKLGDFGLARAFGIPVNTFSSEVVTLW 173 L G+ + H +I H DLKP+N+++ R ++K+ DFGLA N F + T Sbjct: 124 LNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDF-GNEFKNIFGTPE 182 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 + AP+++ D+WS G I +++G F G +E L + + + + Sbjct: 183 FVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYF 241 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 + + L K DF+ LL +P R++ + +L Sbjct: 242 SNTSALAK------------------------------DFIRRLLVKDPKKRMTIQDSLQ 271 Query: 294 HPWFA 298 HPW Sbjct: 272 HPWIK 276 >2Y7J-A nrPDB Length = 365 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 76/307 (24%), Positives = 135/307 (43%), Gaps = 51/307 (16%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-------EGTPSTAIREISLMK 58 ++ + +G G + V + +++ TG A+K +++ +E E RE +++ Sbjct: 95 KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILR 154 Query: 59 EL-KHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 ++ H +I+ L D + + + LVF+ M +L Y+ + L + Sbjct: 155 QVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKV------ALSEKETRSIMRS 208 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 LL+ ++F H N I+HRDLKP+N+L++ Q++L DFG + P T Y A Sbjct: 209 LLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHL-EPGEKLRELCGTPGYLA 267 Query: 177 PDVLMGSR-----TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 P++L S Y +D+W+CG IL ++ G P F L++I + + Sbjct: 268 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 327 Query: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 W + K D + LLQ++P+ RL+A+QA Sbjct: 328 EWDDRSSTVK------------------------------DLISRLLQVDPEARLTAEQA 357 Query: 292 LHHPWFA 298 L HP+F Sbjct: 358 LQHPFFE 364 >3MV5-A nrPDB Length = 342 Score = 249 bits (635), Expect = 1e-66, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 132/304 (43%), Gaps = 48/304 (15%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKEL 60 + ++F+ L+ LG GT+ V K TG Y A+K +K + + + + E +++ Sbjct: 8 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 67 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +H + L T ++L V E+ + + SR R + +++ +++ Sbjct: 68 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR-----ERVFSEDRARFYGAEIVSA 122 Query: 121 LAFCHE-NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 L + H +++RDLK +NL+++K G +K+ DFGL + T + T Y AP+V Sbjct: 123 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 182 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 L + Y ++D W G ++ EM+ G+ F + E+ +LI Sbjct: 183 LEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL----------------- 224 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALHH 294 + ++ P T P L GLL+ +P RL AK+ + H Sbjct: 225 --------------MEEIRFPRTLGP---EAKSLLSGLLKKDPKQRLGGGSEDAKEIMQH 267 Query: 295 PWFA 298 +FA Sbjct: 268 RFFA 271 >3Q53-A nrPDB Length = 306 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 82/300 (27%), Positives = 134/300 (44%), Gaps = 39/300 (13%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 ++ + EK+G G TVY ++ TG VA++++ L ++ I EI +M+E K+ NI Sbjct: 22 KYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNL-QQQPKKELIINEILVMRENKNPNI 80 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 V D ++L +V E++ S T T ++ + + LQ L F H Sbjct: 81 VNYLDSYLVGDELWVVMEYLAGG------SLTDVVTETCMDEGQIAAVCRECLQALEFLH 134 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 N+++HRD+K N+L+ G +KL DFG + S+ V T ++ AP+V+ + Sbjct: 135 SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKA 193 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 Y +DIWS G + EMI G+P + N L LI GTP Sbjct: 194 YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIA-TNGTP----------------- 235 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 + E L DFL+ L+++ + R SAK+ + H + +S Sbjct: 236 -------------ELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLKIAKPLSS 282 >4CFH-A nrPDB Length = 493 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 123/298 (41%), Gaps = 44/298 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE--GTPSTAIREISLMKELKH 62 + + LG GT+ V G ++ TG VA+K + REI +K +H Sbjct: 33 GHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH 92 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +I++LY VI T + + +V E++ L Y+ L+ + Q+L G+ Sbjct: 93 PHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR------LDEKESRRLFQQILSGV 146 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 +CH + ++HRDLKP+N+L++ K+ DFGL+ + + Y AP+V+ Sbjct: 147 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVIS 205 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 G +DIWS G IL ++ G F + K I D + + L PSV Sbjct: 206 GRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV----- 260 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + L +LQ++P R + K H WF + Sbjct: 261 -----------------------------ISLLKHMLQVDPMKRATIKDIREHEWFKQ 289 >2YAB-A nrPDB Length = 361 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 126/302 (41%), Gaps = 48/302 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-----STAIREISLMKELK 61 + E+LG+G +A V K K+TG+ A K +K + RE+S+++++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H NI+ L+DV + L+ E + L ++ + L F Q+L G Sbjct: 74 HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQK------ESLSEEEATSFIKQILDG 127 Query: 121 LAFCHENKILHRDLKPQNLLINKRG----QLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 + + H KI H DLKP+N+++ + +KL DFGLA V F + T + A Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVA 186 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P+++ D+WS G I +++G F G +E L I + +E + Sbjct: 187 PEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQT 245 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 ++L K DF+ LL RL+ ++AL HPW Sbjct: 246 SELAK------------------------------DFIRKLLVKETRKRLTIQEALRHPW 275 Query: 297 FA 298 Sbjct: 276 IT 277 >4CSV-A nrPDB Length = 275 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 121/292 (41%), Gaps = 43/292 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 S+ KLG+G + VY+G + + VA+K +K + + ++E +MK+LKH N Sbjct: 11 SEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTM--SVEEFLQEAQIMKKLKHPN 68 Query: 65 IVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 +V+LY V E + ++ E+M L Y+ + + Q+ G+A+ Sbjct: 69 LVQLYGVCTKEPPIYIITEYMSHGSLLDYLRD----CEGHTVNAQALLDMAAQVASGMAY 124 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT-FSSEVVTLWYRAPDVLMG 182 +HRDL +N L+ + +K+ DFGLAR T + + + AP+ + Sbjct: 125 LESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAISY 184 Query: 183 SRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 +R +S D+W+ G +L E+ T G+ +PG + E ++ + P P Sbjct: 185 NR-FSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCP------- 236 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 + + + +P+ R + + LH Sbjct: 237 --------------------------EEIYELMLQCWNKSPEERPTFAETLH 262 >4NIF-A nrPDB Length = 333 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 74/306 (24%), Positives = 124/306 (40%), Gaps = 53/306 (17%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLM-KELKH 62 S + E +G G+Y+ + ++K T + A+K + + + EI ++ + +H Sbjct: 7 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPS-----EEIEILLRYGQH 61 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND--LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 NI+ L DV + LV E M L K + + + + + Sbjct: 62 PNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQK-------FFSEREASFVLHTIGKT 114 Query: 121 LAFCHENKILHRDLKPQNLL-INKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 + + H ++HRDLKP N+L +++ G L++ DFG A+ + T + A Sbjct: 115 VEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 174 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLF---PGTNDEEQLKLIFDIMGTPNESLW 233 P+VL + Y DIWS G +L M+ G F P EE L I T + W Sbjct: 175 PEVLK-RQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNW 233 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 +V++ K D + +L ++P RL+AKQ L Sbjct: 234 NTVSETAK------------------------------DLVSKMLHVDPHQRLTAKQVLQ 263 Query: 294 HPWFAE 299 HPW + Sbjct: 264 HPWVTQ 269 >5ZTN-A nrPDB Length = 429 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 92/326 (28%), Positives = 166/326 (50%), Gaps = 45/326 (13%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE-- 63 +++ L+ +G G++ V K + +VALK V+ +E+ A EI +++ L+ + Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVR--NEKRFHRQAAEEIRILEHLRKQDK 155 Query: 64 ----NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 N++ + + N + + FE + +L + + N +G L LV+ F +LQ Sbjct: 156 DNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKK----NKFQGFSLPLVRKFAHSILQ 211 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 L H+N+I+H DLKP+N+L+ ++G+ +K+ DFG + + + + +YRAP Sbjct: 212 CLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSC---YEHQRVYTYIQSRFYRAP 268 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +V++G+R Y ID+WS GCILAE++TG PL PG ++ +QL + +++G P++ L + Sbjct: 269 EVILGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLL-DAS 326 Query: 238 KLPKYNPNIQQRP-------------------PRDLRQVLQPHTKE-------PLDGNLM 271 K K + + P R + P ++E D + Sbjct: 327 KRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFL 386 Query: 272 DFLHGLLQLNPDMRLSAKQALHHPWF 297 DFL L+ +P +R++ QAL HPW Sbjct: 387 DFLKQCLEWDPAVRMTPGQALRHPWL 412 >4D2V-A nrPDB Length = 356 Score = 248 bits (633), Expect = 2e-66, Method: Composition-based stats. Identities = 77/299 (25%), Positives = 129/299 (43%), Gaps = 42/299 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 ++ E +G G +A V + TG VA+K + ++ EI +K L+H++I Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHIC 90 Query: 67 RLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 +LY V+ T NK+ +V E+ L Y+ S+ L + Q++ +A+ H Sbjct: 91 QLYHVLETANKIFMVLEYCPGGELFDYIISQDR------LSEEETRVVFRQIVSAVAYVH 144 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGL-ARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 HRDLKP+NLL ++ +LKL DFGL A+ G + L Y AP+++ G Sbjct: 145 SQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKS 204 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 + D+WS G +L ++ G F + I +PK+ Sbjct: 205 YLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKY-----------DVPKW-- 251 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHH 303 L + + L +LQ++P R+S K L+HPW + Y++ Sbjct: 252 ---------------------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNY 289 >4D28-A nrPDB Length = 446 Score = 248 bits (633), Expect = 2e-66, Method: Composition-based stats. Identities = 85/306 (27%), Positives = 134/306 (43%), Gaps = 43/306 (14%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMK 58 M +++ +G GT+A V N TG VA+K + + + REIS+MK Sbjct: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 Query: 59 ELKHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 ++H NIVRLY+V+ +++K+ +V EF+ +L + + L+ + + + QL Sbjct: 65 IVRHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGR------LKEDESRKYFQQL 118 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + +A CH + HRDLKP+NLL++ G LK+ DFGL+ V + T Y AP Sbjct: 119 VDAVAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAP 178 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +VL G ++ DIWSCG IL ++ G F T+ + I Sbjct: 179 EVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI---------------- 222 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 N PP + +H +L NP R+ + PWF Sbjct: 223 -----NAAEFDCPPW-------------FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWF 264 Query: 298 AEYYHH 303 + Y Sbjct: 265 RKNYVP 270 >4RED-A nrPDB Length = 351 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 76/298 (25%), Positives = 123/298 (41%), Gaps = 44/298 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE--GTPSTAIREISLMKELKH 62 + + LG GT+ V G ++ TG VA+K + REI +K +H Sbjct: 14 GHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH 73 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +I++LY VI T + + +V E++ L Y+ L+ + Q+L G+ Sbjct: 74 PHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR------LDEKESRRLFQQILSGV 127 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 +CH + ++HRDLKP+N+L++ K+ DFGL+ + + Y AP+V+ Sbjct: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVIS 186 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 G +DIWS G IL ++ G F + K I D + + L PSV Sbjct: 187 GRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV----- 241 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + L +LQ++P R S K H WF + Sbjct: 242 -----------------------------ISLLKHMLQVDPMKRASIKDIREHEWFKQ 270 >2JDO-A nrPDB Length = 342 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 69/302 (22%), Positives = 127/302 (42%), Gaps = 47/302 (15%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKEL 60 + + F L+ LG GT+ V K TG Y A+K ++ + + + + E +++ Sbjct: 8 TMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNT 67 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +H + L T ++L V E+ + + SR R +++ +++ Sbjct: 68 RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR-----ERVFTEERARFYGAEIVSA 122 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 L + H +++RD+K +NL+++K G +K+ DFGL + T + T Y AP+VL Sbjct: 123 LEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVL 182 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 + Y ++D W G ++ EM+ G+ F + E +LI Sbjct: 183 EDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL------------------ 223 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALHHP 295 + ++ P T L L GLL+ +P RL AK+ + H Sbjct: 224 -------------MEEIRFPRT---LSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHR 267 Query: 296 WF 297 +F Sbjct: 268 FF 269 >4FZF-B nrPDB Length = 283 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 130/307 (42%), Gaps = 43/307 (14%) Query: 1 MSSSSQ-FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKE 59 M+ + F +LE++G G++ V+KG++ T VA+K + L+ E +EI+++ + Sbjct: 3 MADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 62 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 + + Y +KL ++ E++ + + + + ++L Sbjct: 63 CDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAG-------PFDEFQIATMLKEIL 115 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 +GL + H K +HRD+K N+L++++G +KL FG+A ++ V T ++ AP+ Sbjct: 116 KGLDYLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPE 175 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 V+ S Y + DIWS G E+ G+P + L LI Sbjct: 176 VIQQS-AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLI----------------- 217 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 PK NP P + +F+ L +P R +AK+ L H + Sbjct: 218 -PKNNP---------------PTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIV 261 Query: 299 EYYHHAS 305 + S Sbjct: 262 KNSKKTS 268 >1PHK-A nrPDB Length = 298 Score = 247 bits (631), Expect = 4e-66, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 123/311 (39%), Gaps = 52/311 (16%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKL--------DSEEGTPSTAIREISL 56 ++ E LG G + V + ++K T A+K + + + + ++E+ + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 57 MKELK-HENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQ 114 ++++ H NI++L D T LVF+ M +L Y+ + L + Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKV------TLSEKETRKIM 130 Query: 115 WQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 LL+ + H+ I+HRDLKP+N+L++ +KL DFG + P T Y Sbjct: 131 RALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLD-PGEKLREVCGTPSY 189 Query: 175 RAPDVLM-----GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPN 229 AP+++ Y +D+WS G I+ ++ G P F L++I Sbjct: 190 LAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFG 249 Query: 230 ESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 W + K D + L + P R +A+ Sbjct: 250 SPEWDDYSDTVK------------------------------DLVSRFLVVQPQKRYTAE 279 Query: 290 QALHHPWFAEY 300 +AL HP+F +Y Sbjct: 280 EALAHPFFQQY 290 >4JG6-A nrPDB Length = 355 Score = 247 bits (630), Expect = 6e-66, Method: Composition-based stats. Identities = 71/307 (23%), Positives = 124/307 (40%), Gaps = 53/307 (17%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLM-KELKH 62 + ++ E +G G+Y+ + ++K T + A+K + + T EI ++ + +H Sbjct: 34 TDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPT-----EEIEILLRYGQH 88 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND--LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 NI+ L DV + +V E M L K + + + + + Sbjct: 89 PNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQK-------FFSEREASAVLFTITKT 141 Query: 121 LAFCHENKILHRDLKPQNLL-INKRGQ---LKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 + + H ++HRDLKP N+L +++ G +++ DFG A+ + T + A Sbjct: 142 VEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVA 201 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLF---PGTNDEEQLKLIFDIMGTPNESLW 233 P+VL + Y + DIWS G +L M+TG F P EE L I + + W Sbjct: 202 PEVLE-RQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYW 260 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 SV+ K D + +L ++P RL+A L Sbjct: 261 NSVSDTAK------------------------------DLVSKMLHVDPHQRLTAALVLR 290 Query: 294 HPWFAEY 300 HPW + Sbjct: 291 HPWIVHW 297 >2F57-A nrPDB Length = 317 Score = 247 bits (630), Expect = 6e-66, Method: Composition-based stats. Identities = 74/293 (25%), Positives = 127/293 (43%), Gaps = 39/293 (13%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 K+G G+ V K TG VA+K++ L ++ E+ +M++ H+N+V +Y Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQR-RELLFNEVVIMRDYHHDNVVDMYSS 110 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 ++L +V EF++ + + T N + +L+ L++ H ++H Sbjct: 111 YLVGDELWVVMEFLEGGALTDIVTHTRMN------EEQIATVCLSVLRALSYLHNQGVIH 164 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSID 191 RD+K ++L+ G++KL DFG V S V T ++ AP+V+ Y T +D Sbjct: 165 RDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVI-SRLPYGTEVD 223 Query: 192 IWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPP 251 IWS G ++ EMI G+P + + ++ I D SL P V L K Sbjct: 224 IWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRD-------SLPPRVKDLHK---------- 266 Query: 252 RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHA 304 + L FL +L P R +A++ L HP+ + Sbjct: 267 --------------VSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPS 305 >4KS7-A nrPDB Length = 292 Score = 246 bits (629), Expect = 8e-66, Method: Composition-based stats. Identities = 72/288 (25%), Positives = 127/288 (44%), Gaps = 39/288 (13%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 K+G G+ V K +G VA+K + L ++ E+ +M++ +H N+V +Y Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQR-RELLFNEVVIMRDYQHFNVVEMYKS 88 Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 +L ++ EF+ + S+ L + +LQ LA+ H ++H Sbjct: 89 YLVGEELWVLMEFLQGGALTDIVSQVR------LNEEQIATVCEAVLQALAYLHAQGVIH 142 Query: 132 RDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSID 191 RD+K ++L+ G++KL DFG V S V T ++ AP+V+ S Y+T +D Sbjct: 143 RDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRS-LYATEVD 201 Query: 192 IWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPP 251 IWS G ++ EM+ G+P + + + +K + D PP Sbjct: 202 IWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRD-------------------------SPP 236 Query: 252 RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 L+ + L DFL +L +P R +A++ L HP+ + Sbjct: 237 PKLKN------SHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ 278 >3EB0-A nrPDB Length = 383 Score = 246 bits (629), Expect = 8e-66, Method: Composition-based stats. Identities = 102/339 (30%), Positives = 162/339 (47%), Gaps = 54/339 (15%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 +SS ++ + LG G++ V + + +G ALK+V D P RE+ +MK L Sbjct: 4 TSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQD-----PRYKNRELDIMKVLD 58 Query: 62 HENIVRLYDVIHT--------------------------------------ENKLTLVFE 83 H NI++L D +T L ++ E Sbjct: 59 HVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIME 118 Query: 84 FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLIN- 142 ++ + L K + S + R + +NL+ + +QL + + F H I HRD+KPQNLL+N Sbjct: 119 YVPDTLHKVLKS--FIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNS 176 Query: 143 KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEM 202 K LKL DFG A+ IP + + + +YRAP++++G+ Y+ SID+WS GC+ E+ Sbjct: 177 KDNTLKLCDFGSAKKL-IPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGEL 235 Query: 203 ITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN-IQQRPPRDLRQVLQPH 261 I GKPLF G +QL I IMGTP + + P Y +D R++L Sbjct: 236 ILGKPLFSGETSIDQLVRIIQIMGTPTKEQM--IRMNPHYTEVRFPTLKAKDWRKILPEG 293 Query: 262 TKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300 T +D L +L+ PD+R++ +A+ HP+F Sbjct: 294 TP----SLAIDLLEQILRYEPDLRINPYEAMAHPFFDHL 328 >2YZA-A nrPDB Length = 276 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 74/298 (24%), Positives = 117/298 (39%), Gaps = 44/298 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE--GTPSTAIREISLMKELKH 62 + + LG GT+ V G ++ TG VA+K + REI +K +H Sbjct: 11 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 70 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +I++LY VI T +V E++ L Y+ +E + Q+L + Sbjct: 71 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR------VEEMEARRLFQQILSAV 124 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 +CH + ++HRDLKP+N+L++ K+ DFGL+ + Y AP+V+ Sbjct: 125 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRDSCGSPNYAAPEVIS 183 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 G +DIWSCG IL ++ G F + K I + E L SV Sbjct: 184 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT--- 240 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 L +LQ++P R + K H WF + Sbjct: 241 -------------------------------LLMHMLQVDPLKRATIKDIREHEWFKQ 267 >4JXF-A nrPDB Length = 266 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 74/297 (24%), Positives = 125/297 (42%), Gaps = 43/297 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKELKH 62 FK LG G++A VY+ + TG+ VA+K + K + G E+ + +LKH Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 63 ENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +I+ LY+ N + LV E + ++ +Y+ +R + N ++F Q++ G+ Sbjct: 67 PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRV-----KPFSENEARHFMHQIITGM 121 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 + H + ILHRDL NLL+ + +K+ DFGLA +P + T Y +P+ + Sbjct: 122 LYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-IA 180 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 + D+WS GC+ ++ G+P F + L + Sbjct: 181 TRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV------------------- 221 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + L D +H LL+ NP RLS L HP+ + Sbjct: 222 ---------------LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263 >2YCR-A nrPDB Length = 323 Score = 245 bits (625), Expect = 2e-65, Method: Composition-based stats. Identities = 75/308 (24%), Positives = 133/308 (43%), Gaps = 50/308 (16%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-------EEGTPSTAIREISLM 57 ++ + LG+G V + T VA+K + E EI ++ Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 58 KELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 K+L H I+++ + E+ +V E M+ + + VGN + L+ K + +Q+ Sbjct: 70 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGG---ELFDKVVGN--KRLKEATCKLYFYQM 123 Query: 118 LQGLAFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 L + + HEN I+HRDLKP+N+L++ + +K+ DFG ++ G + + T Y Sbjct: 124 LLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILG-ETSLMRTLCGTPTY 182 Query: 175 RAPDVL--MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLK-LIFDIMGTPNES 231 AP+VL +G+ Y+ ++D WS G IL ++G P F + LK I Sbjct: 183 LAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPE 242 Query: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 +W V++ +D + LL ++P R + ++A Sbjct: 243 VWAEVSE------------------------------KALDLVKKLLVVDPKARFTTEEA 272 Query: 292 LHHPWFAE 299 L HPW + Sbjct: 273 LRHPWLQD 280 >6C9D-A nrPDB Length = 459 Score = 245 bits (625), Expect = 2e-65, Method: Composition-based stats. Identities = 70/290 (24%), Positives = 124/290 (42%), Gaps = 15/290 (5%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHE 63 ++ + +G G +A V + TG VA+K + K + RE+ +MK L H Sbjct: 21 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 80 Query: 64 NIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 NIV+L++VI TE L LV E+ + Y+ + ++ + Q++ + Sbjct: 81 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR------MKEKEARAKFRQIVSAVQ 134 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 +CH+ I+HRDLK +NLL++ +K+ DFG + F + N + Y AP++ G Sbjct: 135 YCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTV-GNKLDEFCGSPPYAAPELFQG 193 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 + +D+WS G IL +++G F G N +E + + + L K Sbjct: 194 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 253 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPD----MRLSA 288 + L Q+++ L + +PD R+ Sbjct: 254 LLVLNPIKRGSLEQIMKDRWMNVGHEEEE--LKPYTEPDPDFNDTKRIDI 301 >2HAK-A nrPDB Length = 328 Score = 245 bits (625), Expect = 2e-65, Method: Composition-based stats. Identities = 70/290 (24%), Positives = 125/290 (43%), Gaps = 15/290 (5%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHE 63 ++ + +G G +A V + TG VA+K + K + RE+ +MK L H Sbjct: 15 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 74 Query: 64 NIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 NIV+L++VI TE L LV E+ + Y+ + ++ + Q++ + Sbjct: 75 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR------MKEKEARAKFRQIVSAVQ 128 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 +CH+ I+HRDLK +NLL++ +K+ DFG + F + N + + Y AP++ G Sbjct: 129 YCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTV-GNKLDTFCGSPPYAAPELFQG 187 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 + +D+WS G IL +++G F G N +E + + + L K Sbjct: 188 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 247 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPD----MRLSA 288 + L Q+++ L + +PD R+ Sbjct: 248 LLVLNPIKRGSLEQIMKDRWMNVGHEEEE--LKPYTEPDPDFNDTKRIDI 295 >2X4F-A nrPDB Length = 373 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 82/296 (27%), Positives = 132/296 (44%), Gaps = 39/296 (13%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E LG G + V+K TG+ +A K +K + EIS+M +L H N+++LYD Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKD-KEEVKNEISVMNQLDHANLIQLYD 153 Query: 71 VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 ++N + LV E++D + R + + EL+ + F Q+ +G+ H+ IL Sbjct: 154 AFESKNDIVLVMEYVDGG---ELFDRIIDESYNLTELDTIL-FMKQICEGIRHMHQMYIL 209 Query: 131 HRDLKPQNLLINKRG--QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYST 188 H DLKP+N+L R Q+K+ DFGLAR + P T + AP+V+ S Sbjct: 210 HLDLKPENILCVNRDAKQIKIIDFGLARRYK-PREKLKVNFGTPEFLAPEVV-NYDFVSF 267 Query: 189 SIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQ 248 D+WS G I +++G F G ND E L I + + +++ Sbjct: 268 PTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISE---------- 317 Query: 249 RPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHA 304 +F+ LL R+SA +AL HPW +++ H+ Sbjct: 318 --------------------EAKEFISKLLIKEKSWRISASEALKHPWLSDHKLHS 353 >6HXF-B nrPDB Length = 302 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 82/295 (27%), Positives = 122/295 (41%), Gaps = 40/295 (13%) Query: 8 KQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVR 67 + + +LG+G + VYK NK TG A K ++ SEE I EI ++ H IV+ Sbjct: 22 EIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEE-ELEDYIVEIEILATCDHPYIVK 80 Query: 68 LYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 L + + KL ++ EF + + RGL ++ Q+L+ L F H Sbjct: 81 LLGAYYHDGKLWIMIEFCPGGAVDAI----MLELDRGLTEPQIQVVCRQMLEALNFLHSK 136 Query: 128 KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL----MGS 183 +I+HRDLK N+L+ G ++L DFG++ + S + T ++ AP+V+ M Sbjct: 137 RIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKD 196 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 Y DIWS G L EM +P N L I K + Sbjct: 197 TPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKI------------------AKSD 238 Query: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 P P + DFL L NP+ R SA Q L HP+ + Sbjct: 239 PPTLLTPSK-------------WSVEFRDFLKIALDKNPETRPSAAQLLEHPFVS 280 >3UC3-A nrPDB Length = 361 Score = 244 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 125/302 (41%), Gaps = 40/302 (13%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 M S ++ ++ +G+G + +K T VA+K ++ + REI + L Sbjct: 16 MHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGA--AIDENVQREIINHRSL 73 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +H NIVR +VI T L ++ E+ + + ++F QLL G Sbjct: 74 RHPNIVRFKEVILTPTHLAIIMEYASGG-----ELYERICNAGRFSEDEARFFFQQLLSG 128 Query: 121 LAFCHENKILHRDLKPQNLLINKRG--QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 +++CH +I HRDLK +N L++ +LK+ DFG +++ + + S V T Y AP+ Sbjct: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAYIAPE 187 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG-TNDEEQLKLIFDIMGTPNESLWPSVT 237 VL+ D+WSCG L M+ G F + K I I+ Sbjct: 188 VLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRIL------------ 235 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 +++ P D+R + + + +P R+S + H WF Sbjct: 236 -------SVKYSIPDDIR----------ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 Query: 298 AE 299 + Sbjct: 279 LK 280 >2A27-A nrPDB Length = 321 Score = 244 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 75/302 (24%), Positives = 126/302 (41%), Gaps = 48/302 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-----STAIREISLMKELK 61 + E+LG+G +A V K K+TG+ A K +K + RE+S+++++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H N++ L+DV + L+ E + L ++ + L F Q+L G Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQK------ESLSEEEATSFIKQILDG 127 Query: 121 LAFCHENKILHRDLKPQNLLINKRG----QLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 + + H KI H DLKP+N+++ + +KL DFGLA V F + T + A Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVA 186 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P+++ D+WS G I +++G F G +E L I + +E + Sbjct: 187 PEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQT 245 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 ++L K DF+ LL RL+ ++AL HPW Sbjct: 246 SELAK------------------------------DFIRKLLVKETRKRLTIQEALRHPW 275 Query: 297 FA 298 Sbjct: 276 IT 277 >5D7A-A nrPDB Length = 308 Score = 243 bits (621), Expect = 7e-65, Method: Composition-based stats. Identities = 79/304 (25%), Positives = 130/304 (42%), Gaps = 48/304 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHENI 65 F+ +E +GNGTY VYKG + TG A+K + + +E +EI+++K+ H NI Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDE--EEEIKQEINMLKKYSHHRNI 76 Query: 66 VRLYDVIHTENK------LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 Y +N L LV EF + T GNT L+ + Y ++L+ Sbjct: 77 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT---LKEEWIAYICREILR 133 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 GL+ H++K++HRD+K QN+L+ + ++KL DFG++ V ++ + T ++ AP+V Sbjct: 134 GLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEV 193 Query: 180 LMGSR----TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 + TY D+WS G EM G P D ++ +F I P L Sbjct: 194 IACDENPDATYDFKSDLWSLGITAIEMAEGAPP---LCDMHPMRALFLIPRNPAPRL--- 247 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 + F+ L N R + +Q + HP Sbjct: 248 --------------------------KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHP 281 Query: 296 WFAE 299 + + Sbjct: 282 FIRD 285 >1ZWS-A nrPDB Length = 288 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 75/302 (24%), Positives = 126/302 (41%), Gaps = 48/302 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP-----STAIREISLMKELK 61 + E+LG+G +A V K K+TG+ A K +K + RE+S+++++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H N++ L+DV + L+ E + L ++ + L F Q+L G Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQK------ESLSEEEATSFIKQILDG 127 Query: 121 LAFCHENKILHRDLKPQNLLINKRG----QLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 + + H KI H DLKP+N+++ + +KL DFGLA V F + T + A Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVA 186 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P+++ D+WS G I +++G F G +E L I + +E + Sbjct: 187 PEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFSHT 245 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 ++L K DF+ LL RL+ ++AL HPW Sbjct: 246 SELAK------------------------------DFIRKLLVKETRKRLTIQEALRHPW 275 Query: 297 FA 298 Sbjct: 276 IT 277 >2W4O-A nrPDB Length = 349 Score = 242 bits (618), Expect = 1e-64, Method: Composition-based stats. Identities = 78/297 (26%), Positives = 122/297 (41%), Gaps = 46/297 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 F+ +LG G + VY+ K T ALK +K ++ T EI ++ L H NI+ Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRT---EIGVLLRLSHPNII 111 Query: 67 RLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 +L ++ T +++LV E + +L + + Q+L+ +A+ H Sbjct: 112 KLKEIFETPTEISLVLELVTGGELFDRIVEKGYY------SERDAADAVKQILEAVAYLH 165 Query: 126 ENKILHRDLKPQNLLINK---RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 EN I+HRDLKP+NLL LK+ DFGL++ V + T Y AP++L G Sbjct: 166 ENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQV-LMKTVCGTPGYCAPEILRG 224 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEE-QLKLIFDIMGTPNESLWPSVTKLPK 241 Y +D+WS G I ++ G F ++ + I + W V Sbjct: 225 C-AYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEV----- 278 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 N D + L+ L+P RL+ QAL HPW Sbjct: 279 -------------------------SLNAKDLVRKLIVLDPKKRLTTFQALQHPWVT 310 >5JZN-A nrPDB Length = 280 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 73/302 (24%), Positives = 122/302 (40%), Gaps = 45/302 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 + ++K +G+G +A V + + ++T ALK +K G E+S+++ +KH Sbjct: 18 TERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHP 77 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 NIV L + + +L LV E + D + + L + + Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKGG-----DLFDAITSTNKYTERDASGMLYNLASAIKY 132 Query: 124 CHENKILHRDLKPQNLLI----NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 H I+HRD+KP+NLL+ + LKLGDFGLA P + T Y AP++ Sbjct: 133 LHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGP---LYTVCGTPTYVAPEI 189 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEE--QLKLIFDIMGTPNESLWPSVT 237 + Y +DIW+ G I ++ G P F G+ D++ I W +V+ Sbjct: 190 I-AETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVS 248 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + + + +L ++ D R SA Q L HPW Sbjct: 249 D------------------------------SAKELITMMLLVDVDQRFSAVQVLEHPWV 278 Query: 298 AE 299 + Sbjct: 279 ND 280 >3I6U-A nrPDB Length = 419 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 74/308 (24%), Positives = 133/308 (43%), Gaps = 50/308 (16%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-------EEGTPSTAIREISLM 57 ++ + LG+G V + T VA++ + E EI ++ Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 58 KELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 K+L H I+++ + E+ +V E M+ + + VGN + L+ K + +Q+ Sbjct: 195 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGG---ELFDKVVGN--KRLKEATCKLYFYQM 248 Query: 118 LQGLAFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 L + + HEN I+HRDLKP+N+L++ + +K+ DFG ++ G + + T Y Sbjct: 249 LLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILG-ETSLMRTLCGTPTY 307 Query: 175 RAPDVL--MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLK-LIFDIMGTPNES 231 AP+VL +G+ Y+ ++D WS G IL ++G P F + LK I Sbjct: 308 LAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPE 367 Query: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 +W V++ +D + LL ++P R + ++A Sbjct: 368 VWAEVSE------------------------------KALDLVKKLLVVDPKARFTTEEA 397 Query: 292 LHHPWFAE 299 L HPW + Sbjct: 398 LRHPWLQD 405 >5D9K-A nrPDB Length = 330 Score = 240 bits (614), Expect = 4e-64, Method: Composition-based stats. Identities = 77/307 (25%), Positives = 128/307 (41%), Gaps = 51/307 (16%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNK---TTGVYVALKEVKLDSEE-GTPSTAIREISLM 57 + SQF+ L+ LG G++ V+ A+K +K + + E ++ Sbjct: 27 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDIL 86 Query: 58 KELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 E+ H IV+L+ TE KL L+ +F+ D T + VK++ +L Sbjct: 87 VEVNHPFIVKLHYAFQTEGKLYLILDFLRGG-----DLFTRLSKEVMFTEEDVKFYLAEL 141 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 L H I++RDLKP+N+L+++ G +KL DFGL++ S T+ Y AP Sbjct: 142 ALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAP 201 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDI-MGTPNESLWPSV 236 +V+ R ++ S D WS G ++ EM+TG F G + +E + +I +G P Sbjct: 202 EVV-NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP-------- 252 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA-----KQA 291 + L L L + NP RL A ++ Sbjct: 253 ---------------------------QFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEI 285 Query: 292 LHHPWFA 298 H +F+ Sbjct: 286 KRHSFFS 292 >3ZUT-A nrPDB Length = 362 Score = 240 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 121/301 (40%), Gaps = 38/301 (12%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 M S +++ ++ +G+G + +K + VA+K + + E REI + L Sbjct: 15 MHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREIINHRSL 72 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +H NIVR +VI T L +V E+ + + ++F QL+ G Sbjct: 73 RHPNIVRFKEVILTPTHLAIVMEYASGG-----ELFERICNAGRFSEDEARFFFQQLISG 127 Query: 121 LAFCHENKILHRDLKPQNLLINKRG--QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 +++CH ++ HRDLK +N L++ +LK+ FG +++ + + S V T Y AP+ Sbjct: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKS-SVLHSQPKSTVGTPAYIAPE 186 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL+ D+WSCG L M+ G F Sbjct: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFED--------------------------- 219 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 P+ N ++ R L + + + +P R+S + +H WF Sbjct: 220 -PEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 Query: 299 E 299 + Sbjct: 279 K 279 >4B6L-A nrPDB Length = 281 Score = 240 bits (613), Expect = 6e-64, Method: Composition-based stats. Identities = 76/304 (25%), Positives = 121/304 (39%), Gaps = 44/304 (14%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKEL 60 S + + LG G +A Y+ + TG A+K + ++ + EI L ++L Sbjct: 7 SGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDL 66 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 +H +IVR + + + E L +R L V+Y+ Q+L Sbjct: 67 QHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARH------TLLEPEVRYYLRQILS 120 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 GL + H+ ILHRDLK N I + +LK+GDFGLA P + T Y AP+V Sbjct: 121 GLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEV 180 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 L+ + + D+WS GC++ ++ G P F + +E + I + T SL Sbjct: 181 LL-RQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASL------- 232 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 L +L+ +P R S Q L H +F + Sbjct: 233 ---------------------------SLPARQLLAAILRASPRDRPSIDQILRHDFFTK 265 Query: 300 YYHH 303 Y Sbjct: 266 GYTP 269 >4CRL-A nrPDB Length = 406 Score = 240 bits (612), Expect = 8e-64, Method: Composition-based stats. Identities = 106/328 (32%), Positives = 177/328 (53%), Gaps = 33/328 (10%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVY--VALKEVKLDSEEGTPSTAIREISLMKELKHE 63 +++ + G GTY VYK K ALK+++ G +A REI+L++ELKH Sbjct: 24 EYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQIE---GTGISMSACREIALLRELKHP 79 Query: 64 NIVRLYDVI--HTENKLTLVFEFMDNDLKKYMDSRTVGN---TPRGLELNLVKYFQWQLL 118 N++ L V H + K+ L+F++ ++DL + P L +VK +Q+L Sbjct: 80 NVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQIL 139 Query: 119 QGLAFCHENKILHRDLKPQNLLIN----KRGQLKLGDFGLARAFGIPVNTFSSE---VVT 171 G+ + H N +LHRDLKP N+L+ +RG++K+ D G AR F P+ + VVT Sbjct: 140 DGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVT 199 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDE---------EQLKLIF 222 WYRAP++L+G+R Y+ +IDIW+ GCI AE++T +P+F ++ +QL IF Sbjct: 200 FWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIF 259 Query: 223 DIMGTPNESLWPSVTKLPKYNPNIQQRPP-----RDLRQVLQPHTKEPLDGNLMDFLHGL 277 ++MG P + W + K+P+++ ++ L + ++ H +P D L L Sbjct: 260 NVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKP-DSKAFHLLQKL 318 Query: 278 LQLNPDMRLSAKQALHHPWFAEYYHHAS 305 L ++P R++++QA+ P+F E S Sbjct: 319 LTMDPIKRITSEQAMQDPYFLEDPLPTS 346 >6FDY-U nrPDB Length = 276 Score = 240 bits (612), Expect = 8e-64, Method: Composition-based stats. Identities = 88/303 (29%), Positives = 137/303 (45%), Gaps = 44/303 (14%) Query: 7 FKQLEKLGNGTYATVYKGL-NKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHEN 64 F E+LG+GTYATVYK K T VA+K V K + + + EI ++K ++H + Sbjct: 13 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPH 72 Query: 65 IVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 IV+L D + + L+ EF DL +++ +R R L + + F QL L F Sbjct: 73 IVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTR------RILPEKVARVFMQQLASALQF 126 Query: 124 CHENKILHRDLKPQNLLIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 HE I H DLKPQN+L++ ++ LKL DFG A+ P + + Y AP+++ Sbjct: 127 LHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMS-PWDEKHVLRGSPLYMAPEMV- 184 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 R Y +D+WS G IL E + G+P F + E + I Sbjct: 185 CQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRS------------------ 226 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 +V++ + L + D L LL+ +P R+S + HPW + Sbjct: 227 -------------NRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEH 273 Query: 302 HHA 304 + Sbjct: 274 MPS 276 >3UTO-A nrPDB Length = 573 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 75/296 (25%), Positives = 127/296 (42%), Gaps = 39/296 (13%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 + E+LG G + V++ + TG A K V + E T +EI M L+H Sbjct: 157 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV-MTPHESDKETVRKEIQTMSVLRHPT 215 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 +V L+D +N++ +++EFM V + + + + Q+ +GL Sbjct: 216 LVNLHDAFEDDNEMVMIYEFMSGGEL----FEKVADEHNKMSEDEAVEYMRQVCKGLCHM 271 Query: 125 HENKILHRDLKPQNLLIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 HEN +H DLKP+N++ + +LKL DFGL P + T + AP+V G Sbjct: 272 HENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLD-PKQSVKVTTGTAEFAAPEVAEG 330 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 + D+WS G + +++G F G ND+E L+ + ++S + +++ K Sbjct: 331 -KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGK- 388 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 DF+ LL +P+ R++ QAL HPW Sbjct: 389 -----------------------------DFIRKLLLADPNTRMTIHQALEHPWLT 415 >3UDB-A nrPDB Length = 317 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 119/301 (39%), Gaps = 38/301 (12%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 M S +++ ++ +G G + +K VA+K + + E REI + L Sbjct: 15 MHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYI--ERGEKIDENVKREIINHRSL 72 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +H NIVR +VI T L +V E+ + + ++F QL+ G Sbjct: 73 RHPNIVRFKEVILTPTHLAIVMEYASGG-----ELFERICNAGRFSEDEARFFFQQLISG 127 Query: 121 LAFCHENKILHRDLKPQNLLINKRG--QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 +++ H ++ HRDLK +N L++ +LK+ DFG ++A + + S V T Y AP+ Sbjct: 128 VSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKA-SVLHSQPKSAVGTPAYIAPE 186 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL+ D+WSCG L M+ G F Sbjct: 187 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFED--------------------------- 219 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 P+ N ++ R L + + + +P R+S + +H WF Sbjct: 220 -PEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWFL 278 Query: 299 E 299 + Sbjct: 279 K 279 >4L42-A nrPDB Length = 346 Score = 238 bits (607), Expect = 2e-63, Method: Composition-based stats. Identities = 75/309 (24%), Positives = 123/309 (39%), Gaps = 51/309 (16%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNK---TTGVYVALKEVKLD---SEEGTPSTAIREISL 56 F+ L LG G Y V++ TG A+K +K + E ++ Sbjct: 16 RPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI 75 Query: 57 MKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 ++E+KH IV L T KL L+ E++ + + ++ + Sbjct: 76 LEEVKHPFIVDLIYAFQTGGKLYLILEYLSGG-----ELFMQLEREGIFMEDTACFYLAE 130 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 + L H+ I++RDLKP+N+++N +G +KL DFGL + + T+ Y A Sbjct: 131 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 190 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P++LM S ++ ++D WS G ++ +M+TG P F G N ++ + I Sbjct: 191 PEILMRS-GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK----------- 238 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQA 291 LP Y L D L LL+ N RL A + Sbjct: 239 LNLPPY-----------------------LTQEARDLLKKLLKRNAASRLGAGPGDAGEV 275 Query: 292 LHHPWFAEY 300 HP+F Sbjct: 276 QAHPFFRHI 284 >4I6B-A nrPDB Length = 308 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 73/305 (23%), Positives = 128/305 (41%), Gaps = 44/305 (14%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKE 59 ++ ++ + + LG G +A Y+ + T A K + S+ +EI L + Sbjct: 25 TTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRI 84 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 L H+++V+ Y + + ++ E+ + + +R V L V+Y+ Q++ Sbjct: 85 LHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKV------LTEPEVRYYLRQIV 138 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 GL + HE +ILHRDLK N IN+ +LK+GDFGLA + + T Y +P+ Sbjct: 139 SGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPE 198 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL + + DIW+ GC++ M+ G+P F TN +E + I + T SL Sbjct: 199 VL-NKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLL----- 252 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + +L NP+ R S + H +F Sbjct: 253 -----------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFFT 283 Query: 299 EYYHH 303 + + Sbjct: 284 QGFTP 288 >2Z7Q-A nrPDB Length = 321 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 76/307 (24%), Positives = 130/307 (42%), Gaps = 51/307 (16%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNK---TTGVYVALKEVKLDSEE-GTPSTAIREISLM 57 + S F+ L+ LG G++ V+ +G A+K +K + + E ++ Sbjct: 25 ADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDIL 84 Query: 58 KELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 ++ H +V+L+ TE KL L+ +F+ D T + VK++ +L Sbjct: 85 ADVNHPFVVKLHYAFQTEGKLYLILDFLRGG-----DLFTRLSKEVMFTEEDVKFYLAEL 139 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 GL H I++RDLKP+N+L+++ G +KL DFGL++ S T+ Y AP Sbjct: 140 ALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAP 199 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDI-MGTPNESLWPSV 236 +V+ + +S S D WS G ++ EM+TG F G + +E + LI +G P Sbjct: 200 EVV-NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP-------- 250 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQA 291 + L L L + NP RL A++ Sbjct: 251 ---------------------------QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEI 283 Query: 292 LHHPWFA 298 H +++ Sbjct: 284 KRHVFYS 290 >3HDN-A nrPDB Length = 373 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 74/305 (24%), Positives = 132/305 (43%), Gaps = 49/305 (16%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLM-K 58 + S F L+ +G G++ V +K V+ A+K ++ + ++ + E +++ K Sbjct: 35 AKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLK 94 Query: 59 ELKHENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 +KH +V L+ T +KL V ++++ L ++ PR +++ ++ Sbjct: 95 NVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPR------ARFYAAEI 148 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 L + H I++RDLKP+N+L++ +G + L DFGL + +T S+ T Y AP Sbjct: 149 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 208 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +VL + Y ++D W G +L EM+ G P F N E I + L P++T Sbjct: 209 EVLH-KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN----KPLQLKPNIT 263 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK----QALH 293 + L GLLQ + RL AK + Sbjct: 264 N------------------------------SARHLLEGLLQKDRTKRLGAKDDFMEIKS 293 Query: 294 HPWFA 298 H +F+ Sbjct: 294 HVFFS 298 >1KOA-A nrPDB Length = 491 Score = 236 bits (603), Expect = 8e-63, Method: Composition-based stats. Identities = 75/296 (25%), Positives = 127/296 (42%), Gaps = 39/296 (13%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 + E+LG G + V++ + TG A K V + E T +EI M L+H Sbjct: 51 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV-MTPHESDKETVRKEIQTMSVLRHPT 109 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 +V L+D +N++ +++EFM V + + + + Q+ +GL Sbjct: 110 LVNLHDAFEDDNEMVMIYEFMSGGEL----FEKVADEHNKMSEDEAVEYMRQVCKGLCHM 165 Query: 125 HENKILHRDLKPQNLLIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 HEN +H DLKP+N++ + +LKL DFGL P + T + AP+V G Sbjct: 166 HENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLD-PKQSVKVTTGTAEFAAPEVAEG 224 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 + D+WS G + +++G F G ND+E L+ + ++S + +++ K Sbjct: 225 -KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGK- 282 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 DF+ LL +P+ R++ QAL HPW Sbjct: 283 -----------------------------DFIRKLLLADPNTRMTIHQALEHPWLT 309 >6CMJ-A nrPDB Length = 321 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 68/310 (21%), Positives = 131/310 (42%), Gaps = 52/310 (16%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS----------EEGTPSTAIREI 54 Q+ +++G G+Y V N+ Y A+K + G +EI Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEI 93 Query: 55 SLMKELKHENIVRLYDVIHT--ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKY 112 +++K+L H N+V+L +V+ E+ L +VFE ++ T + L + ++ Sbjct: 94 AILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPV------MEVPTLKPLSEDQARF 147 Query: 113 FQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTL 172 + L++G+ + H KI+HRD+KP NLL+ + G +K+ DFG++ F S+ V T Sbjct: 148 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 207 Query: 173 WYRAPDVLMGSRTY--STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNE 230 + AP+ L +R ++D+W+ G L + G+ F + + + + Sbjct: 208 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-----------MDERIMCLHS 256 Query: 231 SLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 + + P + + +L D + +L NP+ R+ + Sbjct: 257 KIKSQALEFPD---------------------QPDIAEDLKDLITRMLDKNPESRIVVPE 295 Query: 291 ALHHPWFAEY 300 HPW + Sbjct: 296 IKLHPWVTRH 305 >1FOT-A nrPDB Length = 318 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 64/305 (20%), Positives = 124/305 (40%), Gaps = 52/305 (17%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKEL 60 S F+ L LG G++ V+ ++ G Y A+K +K + E ++ + Sbjct: 4 SLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIV 63 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H I+R++ ++ ++ ++++ L + P + K++ ++ Sbjct: 64 THPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNP------VAKFYAAEVCL 117 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 L + H I++RDLKP+N+L++K G +K+ DFG A+ + + T Y AP+V Sbjct: 118 ALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVP---DVTYTLCGTPDYIAPEV 174 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 + ++ Y+ SID WS G ++ EM+ G F +N + + I + Sbjct: 175 V-STKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPF-------- 225 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALHH 294 + ++ D L L+ + RL + +H Sbjct: 226 --------------------------FNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNH 259 Query: 295 PWFAE 299 PWF E Sbjct: 260 PWFKE 264 >4RLP-A nrPDB Length = 288 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 75/309 (24%), Positives = 123/309 (39%), Gaps = 51/309 (16%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNK---TTGVYVALKEVKLD---SEEGTPSTAIREISL 56 F+ L LG G Y V++ TG A+K +K + E ++ Sbjct: 3 RPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI 62 Query: 57 MKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 ++E+KH IV L T KL L+ E++ + + ++ + Sbjct: 63 LEEVKHPFIVDLIYAFQTGGKLYLILEYLSGG-----ELFMQLEREGIFMEDTACFYLAE 117 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 + L H+ I++RDLKP+N+++N +G +KL DFGL + + T+ Y A Sbjct: 118 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 177 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P++LM S ++ ++D WS G ++ +M+TG P F G N ++ + I Sbjct: 178 PEILMRS-GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK----------- 225 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQA 291 LP Y L D L LL+ N RL A + Sbjct: 226 LNLPPY-----------------------LTQEARDLLKKLLKRNAASRLGAGPGDAGEV 262 Query: 292 LHHPWFAEY 300 HP+F Sbjct: 263 QAHPFFRHI 271 >2HW6-A nrPDB Length = 307 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 68/304 (22%), Positives = 115/304 (37%), Gaps = 38/304 (12%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HENIVRLY 69 E LG G YA V ++ G A+K ++ + S RE+ + + + ++NI+ L Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHS-RSRVFREVETLYQCQGNKNILELI 77 Query: 70 DVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 + + + LVFE + ++ + + + L F H Sbjct: 78 EFFEDDTRFYLVFEKLQGGSILAHIQKQ------KHFNEREASRVVRDVAAALDFLHTKG 131 Query: 129 ILHRDLKPQNLLINKR---GQLKLGDFGLARAFG-------IPVNTFSSEVVTLWYRAPD 178 I HRDLKP+N+L +K+ DF L I ++ + Y AP+ Sbjct: 132 IAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPE 191 Query: 179 VLM----GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 V+ + Y D+WS G +L M++G P F G + ++ L+ Sbjct: 192 VVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFE 251 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 S+ + + P +D + D + LL + RLSA Q L H Sbjct: 252 SIQEGKY------EFPDKDWAHI---------SSEAKDLISKLLVRDAKQRLSAAQVLQH 296 Query: 295 PWFA 298 PW Sbjct: 297 PWVQ 300 >3TXO-A nrPDB Length = 353 Score = 235 bits (599), Expect = 2e-62, Method: Composition-based stats. Identities = 72/306 (23%), Positives = 127/306 (41%), Gaps = 51/306 (16%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKEL-K 61 F+ + LG G++ V K TG A+K +K D ++ + E ++ Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 62 HENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H + +L+ T ++L V EF+ DL ++ R + +++ +++ Sbjct: 83 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQK------SRRFDEARARFYAAEIISA 136 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 L F H+ I++RDLK N+L++ G KL DFG+ + T ++ T Y AP++L Sbjct: 137 LMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 196 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 Y ++D W+ G +L EM+ G F N+++ + I + +E ++P+ Sbjct: 197 Q-EMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN-----DEVVYPT----- 245 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-SAKQ-----ALHH 294 L + L + NP MRL S Q L H Sbjct: 246 ------------------------WLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRH 281 Query: 295 PWFAEY 300 P+F E Sbjct: 282 PFFKEI 287 >5KKR-C nrPDB Length = 395 Score = 233 bits (596), Expect = 5e-62, Method: Composition-based stats. Identities = 82/308 (26%), Positives = 145/308 (47%), Gaps = 23/308 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 F+++ +LG G V+K +K +G+ +A K + L+ + + IRE+ ++ E Sbjct: 67 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 126 Query: 64 NIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 IV Y +++ ++++ E MD L + + + ++ +++GL Sbjct: 127 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR------IPEQILGKVSIAVIKGLT 180 Query: 123 FC-HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 + ++KI+HRD+KP N+L+N RG++KL DFG++ + +S V T Y +P+ L Sbjct: 181 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQ 238 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIF--DIMGTPNESLWPSVTKL 239 G+ YS DIWS G L EM G+ P + +E L+L+F + G E+ T Sbjct: 239 GT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE-LELMFGCQVEGDAAETPPRPRTPG 296 Query: 240 PKYNPN-IQQRPPRDLRQVLQPHTKEP--------LDGNLMDFLHGLLQLNPDMRLSAKQ 290 + + RPP + ++L EP DF++ L NP R KQ Sbjct: 297 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQ 356 Query: 291 ALHHPWFA 298 + H + Sbjct: 357 LMVHAFIK 364 >3DB8-A nrPDB Length = 317 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 117/304 (38%), Gaps = 44/304 (14%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKEL 60 + ++ + LG G +A Y+ + T A K V + EI++ K L Sbjct: 40 TMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSL 99 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 + ++V + ++ + +V E L + R + + +YF Q +Q Sbjct: 100 DNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRR------KAVTEPEARYFMRQTIQ 153 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 G+ + H N+++HRDLK NL +N +K+GDFGLA T Y AP+V Sbjct: 154 GVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEV 213 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 L + +S +DIWS GCIL ++ GKP F + +E I + + P + Sbjct: 214 L-CKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASA- 271 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + +L +P +R S + L +F Sbjct: 272 ---------------------------------LIRRMLHADPTLRPSVAELLTDEFFTS 298 Query: 300 YYHH 303 Y Sbjct: 299 GYAP 302 >5F9E-A nrPDB Length = 353 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 71/301 (23%), Positives = 126/301 (41%), Gaps = 46/301 (15%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKEL-K 61 F+ + LG G++ V+ K T + A+K +K D + + E ++ + Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWE 78 Query: 62 HENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H + ++ T+ L V E++ DL ++ S +L+ ++ +++ G Sbjct: 79 HPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQS------CHKFDLSRATFYAAEIILG 132 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 L F H I++RDLK N+L++K G +K+ DFG+ + + + T Y AP++L Sbjct: 133 LQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEIL 192 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 +G + Y+ S+D WS G +L EM+ G+ F G ++EE I Sbjct: 193 LGQK-YNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI------------------- 232 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK-QALHHPWFAE 299 ++ P L+ D L L P+ RL + HP F E Sbjct: 233 ---------------RMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFRE 277 Query: 300 Y 300 Sbjct: 278 I 278 >3EQC-A nrPDB Length = 360 Score = 232 bits (592), Expect = 1e-61, Method: Composition-based stats. Identities = 83/308 (26%), Positives = 145/308 (47%), Gaps = 23/308 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 F+++ +LG G V+K +K +G+ +A K + L+ + + IRE+ ++ E Sbjct: 32 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 91 Query: 64 NIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 IV Y +++ ++++ E MD L + + + ++ +++GL Sbjct: 92 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR------IPEQILGKVSIAVIKGLT 145 Query: 123 FC-HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 + ++KI+HRD+KP N+L+N RG++KL DFG++ + +S V T Y +P+ L Sbjct: 146 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQ 203 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIF--DIMGTPNESLWPSVTKL 239 G+ YS DIWS G L EM G+ P + +E L+L+F + G E+ T Sbjct: 204 GT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE-LELMFGCQVEGDAAETPPRPRTPG 261 Query: 240 PKYNP-NIQQRPPRDLRQVLQPHTKEP--------LDGNLMDFLHGLLQLNPDMRLSAKQ 290 N + RPP + ++L EP DF++ L NP R KQ Sbjct: 262 RPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 321 Query: 291 ALHHPWFA 298 + H + Sbjct: 322 LMVHAFIK 329 >5LOH-A nrPDB Length = 341 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 72/306 (23%), Positives = 122/306 (39%), Gaps = 49/306 (16%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE--EGTPSTAIREISLMKEL 60 S +F ++ + G + VY G G A+K VK + E + Sbjct: 34 SIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALS 91 Query: 61 KHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 K IV LY + + N + LV E++ D+K + + + + ++ Sbjct: 92 KSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGY------FDEEMAVKYISEVAL 145 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLAR------AFGIPVNTFSSEVVTLW 173 L + H + I+HRDLKP N+LI+ G +KL DFGL++ + + T + T Sbjct: 146 ALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPD 205 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 Y AP++L+G R + ++D W+ G L E +TG P F ++ + I Sbjct: 206 YLAPELLLG-RAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILK---------- 254 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 R + P +E L N + LL ++ R K+ Sbjct: 255 ---------------------RDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKR 293 Query: 294 HPWFAE 299 HP F++ Sbjct: 294 HPLFSD 299 >2WO6-A nrPDB Length = 382 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 91/336 (27%), Positives = 153/336 (45%), Gaps = 50/336 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-H 62 +++ +G G++ V K ++ +VA+K +K +++ + A E+ L++ + H Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIK--NKKAFLNQAQIEVRLLELMNKH 110 Query: 63 E-----NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 + IV L N L LVFE + +L + + RG+ LNL + F Q+ Sbjct: 111 DTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRN----TNFRGVSLNLTRKFAQQM 166 Query: 118 LQGLAFCH--ENKILHRDLKPQNLLINK--RGQLKLGDFGLARAFGIPVNTFSSEVVTLW 173 L F E I+H DLKP+N+L+ R +K+ DFG + G + + + + + Sbjct: 167 CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQY---IQSRF 223 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 YR+P+VL+G Y +ID+WS GCIL EM TG+PLF G N+ +Q+ I +++G P + Sbjct: 224 YRSPEVLLG-MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHIL 282 Query: 234 PSVTKLPKYNPNIQQ---------------RPP--RDLRQVLQPHTKEPLDG-------- 268 K K+ + +PP R L +L T P Sbjct: 283 DQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHT 342 Query: 269 -----NLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 D + +L +P R+ AL H +F + Sbjct: 343 VADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKK 378 >4B8L-A nrPDB Length = 286 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 76/299 (25%), Positives = 121/299 (40%), Gaps = 46/299 (15%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKEL 60 + F LG G + VY K +ALK + +EG REI + L Sbjct: 13 TIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHL 72 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 +H NI+R+Y+ H ++ L+ EF +L K + + R F +L Sbjct: 73 RHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSAT------FMEELAD 126 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 L +CHE K++HRD+KP+NLL+ +G+LK+ DFG + P + TL Y P++ Sbjct: 127 ALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWS--VHAPSLRRRTMCGTLDYLPPEM 184 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 + G +T+ +D+W G + E + G P F + E + I ++ L Sbjct: 185 IEG-KTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFL------- 236 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 D + LL+ +P RL K + HPW Sbjct: 237 ---------------------------SDGSKDLISKLLRYHPPQRLPLKGVMEHPWVK 268 >4YNZ-A nrPDB Length = 342 Score = 231 bits (589), Expect = 3e-61, Method: Composition-based stats. Identities = 69/292 (23%), Positives = 124/292 (42%), Gaps = 43/292 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKHENI 65 ++ + LG G V G++ T VA+K V + E REI+++K ++H ++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 66 VRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 ++L+DV + L LV E + L Y+ + L + F Q++ L FC Sbjct: 72 LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGR------LTPKEARKFFRQIISALDFC 125 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 H + I HRDLKP+NLL+++R +++ DFG+A + + + + Y P+V+ G + Sbjct: 126 HSHSICHRDLKPENLLLDERNNIRIADFGMAS-LQVGDSLLETSCGSPHYACPEVIRGEK 184 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 D+WSCG IL ++ G F N + L+ + + + P Sbjct: 185 YDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPD--------- 235 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 L G+++++ RL+ + H W Sbjct: 236 -------------------------CQSLLRGMIEVDAARRLTLEHIQKHIW 262 >2OU7-A nrPDB Length = 335 Score = 230 bits (588), Expect = 4e-61, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 116/295 (39%), Gaps = 44/295 (14%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKHENIVRLYD 70 LG G +A ++ + T A K V + EIS+ + L H+++V + Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 71 VIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 + + +V E L + R + L +Y+ Q++ G + H N++ Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRR------KALTEPEARYYLRQIVLGCQYLHRNRV 162 Query: 130 LHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTS 189 +HRDLK NL +N+ ++K+GDFGLA T Y AP+VL + +S Sbjct: 163 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFE 221 Query: 190 IDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQR 249 +D+WS GCI+ ++ GKP F + +E I + + + P Sbjct: 222 VDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINP--------------- 266 Query: 250 PPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHA 304 + +LQ +P R + + L+ +F Y A Sbjct: 267 -------------------VAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPA 302 >5YV8-A nrPDB Length = 298 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 68/323 (21%), Positives = 131/323 (40%), Gaps = 67/323 (20%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS---------------------- 42 +Q+ +++G G+Y V N+ Y A+K + Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 43 ---EEGTPSTAIREISLMKELKHENIVRLYDVIHT--ENKLTLVFEFMDNDLKKYMDSRT 97 G +EI+++K+L H N+V+L +V+ E+ L +VFE ++ Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPV------M 126 Query: 98 VGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARA 157 T + L + +++ L++G+ + H KI+HRD+KP NLL+ + G +K+ DFG++ Sbjct: 127 EVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE 186 Query: 158 FGIPVNTFSSEVVTLWYRAPDVLMGSRTY--STSIDIWSCGCILAEMITGKPLFPGTNDE 215 F S+ V T + AP+ L +R ++D+W+ G L + G+ F Sbjct: 187 FKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF------ 240 Query: 216 EQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLH 275 + + + + + + P + + +L D + Sbjct: 241 -----MDERIMCLHSKIKSQALEFPD---------------------QPDIAEDLKDLIT 274 Query: 276 GLLQLNPDMRLSAKQALHHPWFA 298 +L NP+ R+ + HPW Sbjct: 275 RMLDKNPESRIVVPEIKLHPWVT 297 >5X8I-B nrPDB Length = 346 Score = 230 bits (587), Expect = 5e-61, Method: Composition-based stats. Identities = 77/332 (23%), Positives = 146/332 (43%), Gaps = 50/332 (15%) Query: 4 SSQFKQLEKLGNGTYATVYKGL-NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK- 61 S++++ ++ LG G + V + + +K G +VA+K VK + + A EI +++ L Sbjct: 12 SARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK--NVDRYCEAARSEIQVLEHLNT 69 Query: 62 -HEN----IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 N V++ + + +VFE + ++ L+ ++ +Q Sbjct: 70 TDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLP----FRLDHIRKMAYQ 125 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINK-------------------RGQLKLGDFGLARA 157 + + + F H NK+ H DLKP+N+L + +K+ DFG A Sbjct: 126 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA-- 183 Query: 158 FGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQ 217 S+ V T YRAP+V++ + +S D+WS GCIL E G +FP + +E Sbjct: 184 -TYDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEH 241 Query: 218 LKLIFDIMGTPNESLWPSVTKLPKYNPN------------IQQRPPRDLRQVLQPHTKEP 265 L ++ I+G + + K ++ + R + L++ + E Sbjct: 242 LAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVE- 300 Query: 266 LDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 L D + +L+ +P R++ ++AL HP+F Sbjct: 301 -HERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >4U41-A nrPDB Length = 332 Score = 230 bits (587), Expect = 6e-61, Method: Composition-based stats. Identities = 83/304 (27%), Positives = 129/304 (42%), Gaps = 48/304 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHENI 65 F+ +E +GNGTY VYKG + TG A+K + D E EI+++K+ H NI Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM--DVTEDEEEEIKLEINMLKKYSHHRNI 83 Query: 66 VRLYDVIH------TENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 Y +++L LV EF + T GNT L+ + + Y ++L+ Sbjct: 84 ATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNT---LKEDWIAYISREILR 140 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 GLA H + ++HRD+K QN+L+ + ++KL DFG++ V ++ + T ++ AP+V Sbjct: 141 GLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEV 200 Query: 180 LMGSR----TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 + TY D+WSCG EM G P + L LI Sbjct: 201 IACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLI-------------- 246 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 + PP L+ + G L N R S +Q L HP Sbjct: 247 -----------PRNPPPRLKSKKWSKKFFSF-------IEGCLVKNYMQRPSTEQLLKHP 288 Query: 296 WFAE 299 + + Sbjct: 289 FIRD 292 >3LM0-A nrPDB Length = 327 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 75/307 (24%), Positives = 140/307 (45%), Gaps = 42/307 (13%) Query: 1 MSSSSQFKQL--EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLM 57 M + + F L ++LG G +A V + ++K+TG A K +K + + + EI+++ Sbjct: 23 MENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVL 82 Query: 58 KELK-HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 + K ++ L++V +++ L+ E+ + S + + N V Q Sbjct: 83 ELAKSCPRVINLHEVYENTSEIILILEYAAGG---EIFSLCLPELAEMVSENDVIRLIKQ 139 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINK---RGQLKLGDFGLARAFGIPVNTFSSEVVTLW 173 +L+G+ + H+N I+H DLKPQN+L++ G +K+ DFG++R G + T Sbjct: 140 ILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACE-LREIMGTPE 198 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 Y AP++L +T+ D+W+ G I ++T F G +++E I + +E + Sbjct: 199 YLAPEIL-NYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETF 257 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 SV++L DF+ LL NP+ R +A+ L Sbjct: 258 SSVSQL------------------------------ATDFIQSLLVKNPEKRPTAEICLS 287 Query: 294 HPWFAEY 300 H W ++ Sbjct: 288 HSWLQQW 294 >6O6Q-A nrPDB Length = 335 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 85/303 (28%), Positives = 158/303 (52%), Gaps = 20/303 (6%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL- 60 + ++ L KLG G Y+ V+ G++ V +K +K + REIS++K L Sbjct: 38 NPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIK----REISILKNLV 93 Query: 61 KHENIVRLYDVIHTENKLT--LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 NI+ + DV+ T L+FE ++N +D R++ T ++++ ++LL Sbjct: 94 DGPNIIAMLDVVREPQSKTPGLIFEHINN-----IDFRSLYPT---FTDYDIRFYMYELL 145 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQ-LKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + L + H I+HRD+KP N++I+ + L+L D+GLA + P ++ V + +++ P Sbjct: 146 KALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLA-EYYHPGTEYNVRVASRYFKGP 204 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEM-ITGKPLFPGTNDEEQLKLIFDIMGTPN--ESLWP 234 ++L+ R Y S+D+WS GC+LA M +P F G ++ +QL I ++G+ N + L Sbjct: 205 ELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEK 264 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 L + +I R + + + K+ + +D + LL+ + RL+AK+A+ H Sbjct: 265 YNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKH 324 Query: 295 PWF 297 +F Sbjct: 325 AYF 327 >4J52-A nrPDB Length = 293 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 116/295 (39%), Gaps = 44/295 (14%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKHENIVRLYD 70 LG G +A ++ + T A K V + EIS+ + L H+++V + Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 71 VIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 + + +V E L + R + L +Y+ Q++ G + H N++ Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRR------KALTEPEARYYLRQIVLGCQYLHRNRV 135 Query: 130 LHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTS 189 +HRDLK NL +N+ ++K+GDFGLA T Y AP+VL + +S Sbjct: 136 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFE 194 Query: 190 IDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQR 249 +D+WS GCI+ ++ GKP F + +E I + + + P Sbjct: 195 VDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINP--------------- 239 Query: 250 PPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHA 304 + +LQ +P R + + L+ +F Y A Sbjct: 240 -------------------VAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPA 275 >1KOB-A nrPDB Length = 387 Score = 228 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 120/298 (40%), Gaps = 41/298 (13%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 + LE+LG+G + V++ + K TG K + T EIS+M +L H ++ Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPY-PLDKYTVKNEISIMNQLHHPKLI 111 Query: 67 RLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 L+D + ++ L+ EF+ L + + + V + Q +GL H Sbjct: 112 NLHDAFEDKYEMVLILEFLSGGELFDRIAAEDY-----KMSEAEVINYMRQACEGLKHMH 166 Query: 126 ENKILHRDLKPQNLLINKR--GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 E+ I+H D+KP+N++ + +K+ DFGLA P T + AP+++ Sbjct: 167 EHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLN-PDEIVKVTTATAEFAAPEIV-DR 224 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 D+W+ G + +++G F G +D E L+ + +E + SV Sbjct: 225 EPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSV------- 277 Query: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 DF+ LLQ P RL+ AL HPW + Sbjct: 278 -----------------------SPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDH 312 >3HKO-A nrPDB Length = 345 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 83/346 (23%), Positives = 127/346 (36%), Gaps = 76/346 (21%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS----EEGTPSTAIREISLMKE 59 ++ +G G+Y V + T A+K + + E+ LMK+ Sbjct: 25 QKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKK 84 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDND-----LKKYMDSRT-----------VGNTPR 103 L H NI RLY+V E + LV E L ++D T + P Sbjct: 85 LHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPE 144 Query: 104 GLEL-------------------NLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLI--N 142 E L+ Q+ L + H I HRD+KP+N L N Sbjct: 145 CNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTN 204 Query: 143 KRGQLKLGDFGLARAF----GIPVNTFSSEVVTLWYRAPDVLMG-SRTYSTSIDIWSCGC 197 K ++KL DFGL++ F +++ T ++ AP+VL + +Y D WS G Sbjct: 205 KSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGV 264 Query: 198 ILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQV 257 +L ++ G FPG ND + + + + + P YN Sbjct: 265 LLHLLLMGAVPFPGVNDADTISQVLNKKLCF---------ENPNYNV------------- 302 Query: 258 LQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHH 303 L D L LL N D R A +AL HPW +++ Sbjct: 303 --------LSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSDK 340 >4WNO-A nrPDB Length = 287 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 79/303 (26%), Positives = 138/303 (45%), Gaps = 50/303 (16%) Query: 6 QFKQLEKLGNGTYATVYKGLNKT-TGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 +F + + +G+G +A V+KG ++ + VA+K + + + + +EI ++KELKHEN Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHEN 78 Query: 65 IVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 IV LYD N + LV E+ DL Y+ + R L + ++ F Q+ + Sbjct: 79 IVALYDFQEMANSVYLVMEYCNGGDLADYLHAM------RTLSEDTIRLFLQQIAGAMRL 132 Query: 124 CHENKILHRDLKPQNLLINKRG---------QLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 H I+HRDLKPQN+L++ ++K+ DFG AR + ++ + Y Sbjct: 133 LHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNM-MAATLCGSPMY 191 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 AP+V+M S+ Y D+WS G I+ + +TGK F ++ ++ + N++L P Sbjct: 192 MAPEVIM-SQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD-----LRLFYEKNKTLVP 245 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 ++ R+ P + L N R+ + HH Sbjct: 246 TIP-----------------RETSAPLRQLLLALLQR---------NHKDRMDFDEFFHH 279 Query: 295 PWF 297 P+ Sbjct: 280 PFL 282 >2WQN-A nrPDB Length = 310 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 74/288 (25%), Positives = 123/288 (42%), Gaps = 36/288 (12%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKE 59 ++ + F+ +K+G G ++ VY+ GV VALK+V++ + + I+EI L+K+ Sbjct: 29 NTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQ 88 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 L H N+++ Y +N+L +V E D DL + + + R + V + QL Sbjct: 89 LNHPNVIKYYASFIEDNELNIVLELADAGDLSRMI--KHFKKQKRLIPERTVWKYFVQLC 146 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 L H +++HRD+KP N+ I G +KLGD GL R F S V T +Y +P+ Sbjct: 147 SALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPE 206 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 + + Y+ DIWS GC+L EM + F G + L I Sbjct: 207 RIHEN-GYNFKSDIWSLGCLLYEMAALQSPFYG-DKMNLYSLCKKIEQC----------- 253 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL 286 P + L ++ + +P+ R Sbjct: 254 ------------------DYPPLPSDHYSEELRQLVNMCINPDPEKRP 283 >3ORZ-A nrPDB Length = 316 Score = 227 bits (579), Expect = 4e-60, Method: Composition-based stats. Identities = 68/305 (22%), Positives = 120/305 (39%), Gaps = 52/305 (17%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKH 62 FK + LG G+++TV T A+K ++ +E RE +M L H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 63 ENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 V+LY + KL + + +L KY+ + +++ +++ L Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIG------SFDETCTRFYTAEIVSAL 150 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS--SEVVTLWYRAPDV 179 + H I+HRDLKP+N+L+N+ +++ DFG A+ S V T Y +P+ Sbjct: 151 EYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE- 209 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 L+ ++ S D+W+ GCI+ +++ G P F N+ + I + E +P Sbjct: 210 LLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFP----- 264 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ------ALH 293 D + LL L+ RL ++ Sbjct: 265 -----------------------------KARDLVEKLLVLDATKRLGCEEMEGYGPLKA 295 Query: 294 HPWFA 298 HP+F Sbjct: 296 HPFFE 300 >6FYV-A nrPDB Length = 337 Score = 227 bits (579), Expect = 5e-60, Method: Composition-based stats. Identities = 77/330 (23%), Positives = 146/330 (44%), Gaps = 50/330 (15%) Query: 6 QFKQLEKLGNGTYATVYKGLNKT-TGVYVALKEVKLDSEEGTPSTAIREISLMKELKH-- 62 +++ ++ LG G + V + ++ G++VA+K VK + A EI +++ L Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVK--NVGRYREAARSEIQVLEHLNSTD 72 Query: 63 EN----IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 N V++ + + +VFE + ++ + +++ ++ +Q+ Sbjct: 73 PNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLP----FQIDHIRQMAYQIC 128 Query: 119 QGLAFCHENKILHRDLKPQNLLINK-------------------RGQLKLGDFGLARAFG 159 Q + F H NK+ H DLKP+N+L K +K+ DFG A Sbjct: 129 QSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA---T 185 Query: 160 IPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLK 219 S+ V T YRAP+V++ + +S D+WS GCIL E G +F + +E L Sbjct: 186 YDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLA 244 Query: 220 LIFDIMGTPNESLWPSVTKLPKYNPN------------IQQRPPRDLRQVLQPHTKEPLD 267 ++ I+G + + K ++ N +R + L++ + H +E Sbjct: 245 MMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEE--H 302 Query: 268 GNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 L D + +L+ +P R++ +AL HP+F Sbjct: 303 EKLFDLVRRMLEYDPTQRITLDEALQHPFF 332 >4RA4-A nrPDB Length = 355 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 64/302 (21%), Positives = 122/302 (40%), Gaps = 50/302 (16%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKH 62 + F L LG G++ V K T A+K +K D ++ + E ++ L Sbjct: 20 TDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDK 79 Query: 63 E-NIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 + +L+ T ++L V E++ DL ++ P+ + ++ ++ G Sbjct: 80 PPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAV------FYAAEISIG 133 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 L F H+ I++RDLK N++++ G +K+ DFG+ + + T + T Y AP+++ Sbjct: 134 LFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEII 193 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 + Y S+D W+ G +L EM+ G+P F G +++E + I + Sbjct: 194 -AYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME----------------- 235 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA-----KQALHHP 295 + L + GL+ +P RL + H Sbjct: 236 -----------------HNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHA 278 Query: 296 WF 297 +F Sbjct: 279 FF 280 >1U5R-A nrPDB Length = 348 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 64/295 (21%), Positives = 114/295 (38%), Gaps = 45/295 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP--STAIREISLMKELKHEN 64 F L ++G+G++ VY + VA+K++ ++ I+E+ +++L+H N Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 ++ E+ LV E+ ++ + L+ + LQGLA+ Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK-----KPLQEVEIAAVTHGALQGLAYL 170 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL--MG 182 H + ++HRD+K N+L+++ G +KLGDFG A +S V T ++ AP+V+ M Sbjct: 171 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAMD 226 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 Y +D+WS G E+ KP N L I Sbjct: 227 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ------------------- 267 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 +F+ LQ P R +++ L H + Sbjct: 268 -------------NESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFV 309 >6CQF-A nrPDB Length = 297 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 78/293 (26%), Positives = 127/293 (43%), Gaps = 39/293 (13%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 + L++LG GTY V+K +K +G VALK VK++ ++ ST +EI ++K +H N Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDV-STLQKEILILKTCRHAN 74 Query: 65 IVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 IV + KL + EF L+ + L + Y ++LQGLA+ Sbjct: 75 IVAYHGSYLWLQKLWICMEFCGAGSLQD------IYQVTGSLSELQISYVCREVLQGLAY 128 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV--LM 181 H K +HRD+K N+LIN G+++L DFG++ G + + + T ++ AP+V + Sbjct: 129 LHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVA 188 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 Y+ DIWS G E+ +P + L L+ P P + + K Sbjct: 189 LKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQP-----PRLKEKGK 243 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 + +F+ L +P R SA + L H Sbjct: 244 W------------------------SAAFHNFIKVTLTKSPKKRPSATKMLSH 272 >2GCD-A nrPDB Length = 309 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 64/295 (21%), Positives = 114/295 (38%), Gaps = 45/295 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP--STAIREISLMKELKHEN 64 F L ++G+G++ VY + VA+K++ ++ I+E+ +++L+H N Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 ++ E+ LV E+ ++ + L+ + LQGLA+ Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK-----KPLQEVEIAAVTHGALQGLAYL 131 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL--MG 182 H + ++HRD+K N+L+++ G +KLGDFG A +S V T ++ AP+V+ M Sbjct: 132 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAMD 187 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 Y +D+WS G E+ KP N L I Sbjct: 188 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ------------------- 228 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 +F+ LQ P R +++ L H + Sbjct: 229 -------------NESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFV 270 >6E9W-A nrPDB Length = 443 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 58/245 (23%), Positives = 100/245 (40%), Gaps = 14/245 (5%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAI-REISLMKELK 61 + ++ ++ +G G + V +K+T A+K + K + + + S E +M Sbjct: 101 AEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN 160 Query: 62 HENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +V+L+ + L +V E+M DL M + V +++ +++ Sbjct: 161 SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-------PEKWARFYTAEVVLA 213 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS-SEVVTLWYRAPDV 179 L H +HRD+KP N+L++K G LKL DFG + V T Y +P+V Sbjct: 214 LDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEV 273 Query: 180 LM---GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 L G Y D WS G L EM+ G F + I + + + Sbjct: 274 LKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDI 333 Query: 237 TKLPK 241 +K K Sbjct: 334 SKEAK 338 >6ED6-A nrPDB Length = 415 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 118/310 (38%), Gaps = 50/310 (16%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAI-REISLMKELK 61 + + ++ +G G + V +K + A+K + K + + + S E +M Sbjct: 87 AEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN 146 Query: 62 HENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +V+L+ + L +V E+M DL M + V K++ +++ Sbjct: 147 SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-------PEKWAKFYTAEVVLA 199 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS-SEVVTLWYRAPDV 179 L H ++HRD+KP N+L++K G LKL DFG + V T Y +P+V Sbjct: 200 LDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEV 259 Query: 180 LM---GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 L G Y D WS G L EM+ G F + I D N +P Sbjct: 260 LKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMD---HKNSLCFPED 316 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL---SAKQALH 293 ++ K+ + + L + ++RL ++ Sbjct: 317 AEISKH---------------------------AKNLICAFLT-DREVRLGRNGVEEIRQ 348 Query: 294 HPWFA--EYY 301 HP+F +++ Sbjct: 349 HPFFKNDQWH 358 >3ALO-A nrPDB Length = 327 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 124/308 (40%), Gaps = 37/308 (12%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISL-MKELK 61 ++ K L ++G G Y +V K ++K +G +A+K ++ +E + ++ + M+ Sbjct: 20 TAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSD 79 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 IV+ Y + E + E M K+ + ++ ++ L Sbjct: 80 CPYIVQFYGALFREGDCWICMELMSTSFDKFYK-YVYSVLDDVIPEEILGKITLATVKAL 138 Query: 122 AFCHEN-KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 EN KI+HRD+KP N+L+++ G +KL DFG++ + + + Y AP+ + Sbjct: 139 NHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAK-TRDAGCRPYMAPERI 197 Query: 181 M---GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDE-EQLKLIFDIMGTPNESLWPSV 236 + Y D+WS G L E+ TG+ +P N +QL + G P + Sbjct: 198 DPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK--GDPPQ------ 249 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 L + + ++F++ L + R K+ L HP+ Sbjct: 250 ---------------------LSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPF 288 Query: 297 FAEYYHHA 304 Y A Sbjct: 289 ILMYEERA 296 >2FO0-A nrPDB Length = 495 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 65/283 (22%), Positives = 118/283 (41%), Gaps = 43/283 (15%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 KLG G Y VY+G+ K + VA+K +K D+ E ++E ++MKE+KH N+V+L V Sbjct: 224 KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME--VEEFLKEAAVMKEIKHPNLVQLLGV 281 Query: 72 IHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 E ++ EFM +L Y+ + + ++ Y Q+ + + + + Sbjct: 282 CTREPPFYIITEFMTYGNLLDYLRECNR----QEVNAVVLLYMATQISSAMEYLEKKNFI 337 Query: 131 HRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT-FSSEVVTLWYRAPDVLMGSRTYSTS 189 HR+L +N L+ + +K+ DFGL+R T + + + AP+ L ++ +S Sbjct: 338 HRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK-FSIK 396 Query: 190 IDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQ 248 D+W+ G +L E+ T G +PG + + +L+ P Sbjct: 397 SDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP-------------- 442 Query: 249 RPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 + + + Q NP R S + Sbjct: 443 -------------------EKVYELMRACWQWNPSDRPSFAEI 466 >4APC-A nrPDB Length = 350 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 119/300 (39%), Gaps = 38/300 (12%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKE 59 S ++ +L+K+G G++ + G +KE+ + + RE++++ Sbjct: 20 FQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLAN 79 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 +KH NIV+ + L +V ++ + + R + + + + Q+ Sbjct: 80 MKHPNIVQYRESFEENGSLYIVMDYCEGG---DLFKRINAQKGVLFQEDQILDWFVQICL 136 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 L H+ KILHRD+K QN+ + K G ++LGDFG+AR V + + T +Y +P++ Sbjct: 137 ALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEI 196 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 + Y+ DIW+ GC+L E+ T K F + + + I P Sbjct: 197 CEN-KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPP----------- 244 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 +L + L + NP R S L + A+ Sbjct: 245 ----------------------VSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAK 282 >3KN6-A nrPDB Length = 325 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 121/300 (40%), Gaps = 51/300 (17%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HENIVRLY 69 + LG G+++ K ++K + A+K + + + +EI+ +K + H NIV+L+ Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKII----SKRMEANTQKEITALKLCEGHPNIVKLH 72 Query: 70 DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 +V H + LV E ++ + + Y +L+ ++ H+ + Sbjct: 73 EVFHDQLHTFLVMELLNGG-----ELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 127 Query: 130 LHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY 186 +HRDLKP+NLL N ++K+ DFG AR + TL Y AP+ L+ Y Sbjct: 128 VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LLNQNGY 186 Query: 187 STSIDIWSCGCILAEMITGKPLFPGTNDE-------EQLKLIFDIMGTPNESLWPSVTKL 239 S D+WS G IL M++G+ F + E +K I + W +V Sbjct: 187 DESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNV--- 243 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 D + GLL ++P+ RL ++ W + Sbjct: 244 ---------------------------SQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQD 276 >6CKI-A nrPDB Length = 316 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 74/316 (23%), Positives = 122/316 (38%), Gaps = 43/316 (13%) Query: 4 SSQFKQL-----EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMK 58 S +F+ + + LG G +A V +N T A+K ++ S RE+ ++ Sbjct: 7 SGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGH-IRSRVFREVEMLY 65 Query: 59 ELK-HENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 + + H N++ L + E++ LVFE M + ++ R R Sbjct: 66 QCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKR------RHFNELEASVVVQD 119 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGIPVN-------TFS 166 + L F H I HRDLKP+N+L Q +K+ DFGL + + Sbjct: 120 VASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELL 179 Query: 167 SEVVTLWYRAPDVLMG----SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIF 222 + + Y AP+V+ + Y D+WS G IL +++G P F G + Sbjct: 180 TPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRG 239 Query: 223 DIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNP 282 + L+ S+ + + P +D + D + LL + Sbjct: 240 EACPACQNMLFESIQEGKY------EFPDKDWAHI---------SCAAKDLISKLLVRDA 284 Query: 283 DMRLSAKQALHHPWFA 298 RLSA Q L HPW Sbjct: 285 KQRLSAAQVLQHPWVQ 300 >4XEY-B nrPDB Length = 408 Score = 223 bits (570), Expect = 5e-59, Method: Composition-based stats. Identities = 66/283 (23%), Positives = 118/283 (41%), Gaps = 43/283 (15%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 KLG G Y VY+G+ K + VA+K +K D+ E ++E ++MKE+KH N+V+L V Sbjct: 132 KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME--VEEFLKEAAVMKEIKHPNLVQLLGV 189 Query: 72 IHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 E ++ EFM +L Y+ + + ++ Y Q+ + + + + Sbjct: 190 CTREPPFYIITEFMTYGNLLDYLRECNR----QEVNAVVLLYMATQISSAMEYLEKKNFI 245 Query: 131 HRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT-FSSEVVTLWYRAPDVLMGSRTYSTS 189 HRDL +N L+ + +K+ DFGL+R T + + + AP+ L ++ +S Sbjct: 246 HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK-FSIK 304 Query: 190 IDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQ 248 D+W+ G +L E+ T G +PG + + +L+ P Sbjct: 305 SDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP-------------- 350 Query: 249 RPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 + + + Q NP R S + Sbjct: 351 -------------------EKVYELMRACWQWNPSDRPSFAEI 374 >4E93-A nrPDB Length = 377 Score = 223 bits (570), Expect = 5e-59, Method: Composition-based stats. Identities = 57/287 (19%), Positives = 104/287 (36%), Gaps = 43/287 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 E++G G + V+ G + VA+K + + ++E ++K+ H N Sbjct: 114 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPN 173 Query: 65 IVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 IVRL V + + +V E + D ++ + L + + G+ + Sbjct: 174 IVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGA-----RLRVKTLLQMVGDAAAGMEY 228 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSS--EVVTLWYRAPDVLM 181 +HRDL +N L+ ++ LK+ DFG++R V S V + + AP+ L Sbjct: 229 LESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALN 288 Query: 182 GSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 R YS+ D+WS G +L E + G +P ++++ + + P L P Sbjct: 289 YGR-YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFR- 346 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 + P R S Sbjct: 347 --------------------------------LMEQCWAYEPGQRPS 361 >5MJB-A nrPDB Length = 305 Score = 223 bits (570), Expect = 5e-59, Method: Composition-based stats. Identities = 68/285 (23%), Positives = 127/285 (44%), Gaps = 27/285 (9%) Query: 8 KQLEKLGNGTYATVYKGLNKTTGV---YVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 K E +G G + VYKG K G YVA+K +K E + E S+M + H N Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRN 88 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 I+RL V+ + ++ EFM+N +DS N + + LV + G+ + Sbjct: 89 IIRLEGVVTKSRPVMIITEFMEN---CALDSFLRQNDGQFTVIQLVG-MLRGIAAGMKYL 144 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN--TFSSEVV---TLWYRAPDV 179 E +HRDL +N+L+N K+ DFGL+R + T++S + + + AP+ Sbjct: 145 SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEA 204 Query: 180 LMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 + R ++++ D+WS G ++ E+++ G+ + ++++ + I P P+ Sbjct: 205 I-AYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALH 263 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPD 283 + + R R +++ L +++ NP Sbjct: 264 QLMLDCWQKDRNSRPRF------------AEIVNTLDKMIR-NPA 295 >5X3F-B nrPDB Length = 393 Score = 223 bits (568), Expect = 9e-59, Method: Composition-based stats. Identities = 60/302 (19%), Positives = 121/302 (40%), Gaps = 52/302 (17%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKH 62 QF +++ LG G++ V +K +G + A+K + + + E +++ + Sbjct: 84 DQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 143 Query: 63 ENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +V+L + L +V E++ ++ ++ + P +++ Q++ Sbjct: 144 PFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEP------HARFYAAQIVLTF 197 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 + H +++RDLKP+NLLI+++G +++ DFG A+ T T Y AP++++ Sbjct: 198 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL---CGTPEYLAPEIIL 254 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 S+ Y+ ++D W+ G ++ EM G P F + + I Sbjct: 255 -SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH---------- 303 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALHHPW 296 +L D L LLQ++ R +H W Sbjct: 304 ------------------------FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 339 Query: 297 FA 298 FA Sbjct: 340 FA 341 >4AF3-A nrPDB Length = 292 Score = 223 bits (568), Expect = 9e-59, Method: Composition-based stats. Identities = 74/298 (24%), Positives = 119/298 (39%), Gaps = 46/298 (15%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKEL 60 + F+ LG G + VY K + VALK + +EG REI + L Sbjct: 21 TIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHL 80 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H NI+RLY+ + ++ L+ E+ +L K + + +L Sbjct: 81 HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQK------SCTFDEQRTATIMEELAD 134 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 L +CH K++HRD+KP+NLL+ +G+LK+ DFG + P + TL Y P++ Sbjct: 135 ALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWS--VHAPSLRRKTMCGTLDYLPPEM 192 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 + G R ++ +D+W G + E++ G P F + E + I + S Sbjct: 193 IEG-RMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPAS-------- 243 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + D + LL+ NP RL Q HPW Sbjct: 244 --------------------------VPTGAQDLISKLLRHNPSERLPLAQVSAHPWV 275 >5N23-A nrPDB Length = 352 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 62/302 (20%), Positives = 119/302 (39%), Gaps = 51/302 (16%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKH 62 QF+++ LG G++ V +K TG + A+K + + + E + + + Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNF 101 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +V+L + L +V E+ + ++ + P +++ Q++ Sbjct: 102 PFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEP------HARFYAAQIVLTF 155 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 + H +++RDLKP+NLLI+++G +K+ DFG A+ T + T Y AP++++ Sbjct: 156 EYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVK--GRTPWTLCGTPEYLAPEIIL 213 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 S+ Y+ ++D W+ G ++ EM G P F + + I Sbjct: 214 -SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH---------- 262 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALHHPW 296 +L D L LLQ++ R +H W Sbjct: 263 ------------------------FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 298 Query: 297 FA 298 FA Sbjct: 299 FA 300 >1S9I-A nrPDB Length = 354 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 77/310 (24%), Positives = 138/310 (44%), Gaps = 23/310 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 F+++ +LG G V K ++ +G+ +A K + L+ + + IRE+ ++ E Sbjct: 15 DDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSP 74 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 IV Y +++ ++++ E MD V + + ++ +L+GLA+ Sbjct: 75 YIVGFYGAFYSDGEISICMEHMDGGSLD-----QVLKEAKRIPEEILGKVSIAVLRGLAY 129 Query: 124 CHENK-ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 E I+HRD+KP N+L+N RG++KL DFG++ + +S V T Y AP+ L G Sbjct: 130 LREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMAPERLQG 187 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 + YS DIWS G L E+ G+ P + +E + + E S++ P+ Sbjct: 188 T-HYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP 246 Query: 243 NPN------IQQRPPRDLRQVLQPHTKEP--------LDGNLMDFLHGLLQLNPDMRLSA 288 + RP + ++L EP + +F++ L NP R Sbjct: 247 PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL 306 Query: 289 KQALHHPWFA 298 K +H + Sbjct: 307 KMLTNHTFIK 316 >6QAU-A nrPDB Length = 280 Score = 222 bits (566), Expect = 1e-58, Method: Composition-based stats. Identities = 79/305 (25%), Positives = 136/305 (44%), Gaps = 50/305 (16%) Query: 6 QFKQLEKLGNGTYATVYKGLNK-TTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 ++ + + +G+G +A V++G ++ T VA+K + + + +EI ++KEL+HEN Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHEN 71 Query: 65 IVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 IV LYDV N + LV E+ DL Y+ ++ L + ++ F Q+ + Sbjct: 72 IVALYDVQELPNSVFLVMEYCNGGDLADYLQAKG------TLSEDTIRVFLHQIAAAMRI 125 Query: 124 CHENKILHRDLKPQNLLIN---------KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 H I+HRDLKPQN+L++ ++K+ DFG AR + + + Y Sbjct: 126 LHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNM-MAADLCGSPMY 184 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 AP+V+M S+ Y D+WS G ++ + + GKP F + ++ + N SL P Sbjct: 185 MAPEVIM-SQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD-----LRMFYEKNRSLMP 238 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 S+ PR+ L L N D R+ + H Sbjct: 239 SI--------------PRETSPYLANLLLGLLQRNQKD------------RMDFEAFFSH 272 Query: 295 PWFAE 299 P+ + Sbjct: 273 PFLEQ 277 >4WB7-A nrPDB Length = 405 Score = 222 bits (566), Expect = 1e-58, Method: Composition-based stats. Identities = 61/302 (20%), Positives = 121/302 (40%), Gaps = 52/302 (17%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKH 62 QF++++ LG G++ V +K TG + A+K + + + E +++ + Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 155 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +V+L + L +V E++ + ++ + P +++ Q++ Sbjct: 156 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEP------HARFYAAQIVLTF 209 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 + H +++RDLKP+NLLI+++G +++ DFG A+ T T Y AP++++ Sbjct: 210 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL---CGTPEYLAPEIIL 266 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 S+ Y+ ++D W+ G ++ EM G P F + + I Sbjct: 267 -SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH---------- 315 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALHHPW 296 +L D L LLQ++ R +H W Sbjct: 316 ------------------------FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 351 Query: 297 FA 298 FA Sbjct: 352 FA 353 >6E2O-A nrPDB Length = 295 Score = 222 bits (566), Expect = 1e-58, Method: Composition-based stats. Identities = 79/301 (26%), Positives = 127/301 (42%), Gaps = 43/301 (14%) Query: 6 QFKQLE-----KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 ++ E LG GTY VY G + + V +A+KE+ + + EI+L K L Sbjct: 18 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIP-ERDSRYSQPLHEEIALHKHL 76 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 KH+NIV+ + + E + L + S+ P + ++ Q+L+ Sbjct: 77 KHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKW---GPLKDNEQTIGFYTKQILE 133 Query: 120 GLAFCHENKILHRDLKPQNLLINK-RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 GL + H+N+I+HRD+K N+LIN G LK+ DFG ++ + TL Y AP+ Sbjct: 134 GLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPE 193 Query: 179 VL-MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 ++ G R Y + DIWS GC + EM TGKP F +G P +++ Sbjct: 194 IIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYE-------------LGEPQAAMF---- 236 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + + P E + F+ + +PD R A L + Sbjct: 237 --------------KVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFL 282 Query: 298 A 298 Sbjct: 283 K 283 >3NYO-A nrPDB Length = 576 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 69/305 (22%), Positives = 120/305 (39%), Gaps = 42/305 (13%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGT--PSTAIREISLMKEL 60 + + F+Q LG G + V + TG A K+++ + + A+ E +++++ Sbjct: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +V L T++ L LV M+ + G ++ ++ G Sbjct: 242 NSRFVVSLAYAYETKDALCLVLTLMNGG---DLKFHIYHMGQAGFPEARAVFYAAEICCG 298 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 L H +I++RDLKP+N+L++ G +++ D GLA T V T+ Y AP+V+ Sbjct: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVV 357 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 R Y+ S D W+ GC+L EMI G+ F Sbjct: 358 KNER-YTFSPDWWALGCLLYEMIAGQSPFQ------------------------------ 386 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALHHP 295 + I++ L + + E LL +P RL SA++ HP Sbjct: 387 QRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHP 446 Query: 296 WFAEY 300 F + Sbjct: 447 LFKKL 451 >4P5Q-A nrPDB Length = 361 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 52/262 (19%), Positives = 110/262 (41%), Gaps = 14/262 (5%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVY---VALKEVKLDSEEGTPSTAIREISLMKE 59 ++ + +G G + V G K VA+K +K+ E + E S+M + Sbjct: 31 DATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQ 90 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 H NI+RL V+ + +V E+M+ L ++ + + + Sbjct: 91 FDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQ-----FTVIQLVGMLRGIA 145 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV---TLWYR 175 G+ + + +HRDL +N+LIN K+ DFGL+R + + + Sbjct: 146 SGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWT 205 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 +P+ + R ++++ D+WS G +L E+++ G+ + ++++ +K + + P P Sbjct: 206 SPEAI-AYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCP 264 Query: 235 SVTKLPKYNPNIQQRPPRDLRQ 256 + + + R R + Sbjct: 265 AALYQLMLDCWQKDRNNRPKFE 286 >6NPU-A nrPDB Length = 298 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 66/283 (23%), Positives = 118/283 (41%), Gaps = 43/283 (15%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 KLG G Y VY+G+ K + VA+K +K D+ E ++E ++MKE+KH N+V+L V Sbjct: 33 KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME--VEEFLKEAAVMKEIKHPNLVQLLGV 90 Query: 72 IHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 E ++ EFM +L Y+ + + ++ Y Q+ + + + + Sbjct: 91 CTREPPFYIITEFMTYGNLLDYLRECNR----QEVNAVVLLYMATQISSAMEYLEKKNFI 146 Query: 131 HRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT-FSSEVVTLWYRAPDVLMGSRTYSTS 189 HRDL +N L+ + +K+ DFGL+R T + + + AP+ L ++ +S Sbjct: 147 HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK-FSIK 205 Query: 190 IDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQ 248 D+W+ G +L E+ T G +PG + + +L+ P Sbjct: 206 SDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP-------------- 251 Query: 249 RPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 + + + Q NP R S + Sbjct: 252 -------------------EKVYELMRACWQWNPSDRPSFAEI 275 >3A8W-A nrPDB Length = 345 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 77/302 (25%), Positives = 127/302 (42%), Gaps = 42/302 (13%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKEL-KH 62 F L +G G+YA V K T A+K VK + +++ E + ++ H Sbjct: 10 DFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNH 69 Query: 63 ENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +V L+ TE++L V E++ DL +M + R L +++ ++ L Sbjct: 70 PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQ------RKLPEEHARFYSAEISLAL 123 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 + HE I++RDLK N+L++ G +KL D+G+ + P +T S+ T Y AP++L Sbjct: 124 NYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILR 183 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 G Y S+D W+ G ++ EM+ G+ F DI+G+ + + L + Sbjct: 184 G-EDYGFSVDWWALGVLMFEMMAGRSPF-------------DIVGSSDNPDQNTEDYLFQ 229 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA------KQALHHP 295 Q R PR L L L +P RL HP Sbjct: 230 VILEKQIRIPRSL------------SVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHP 277 Query: 296 WF 297 +F Sbjct: 278 FF 279 >5A46-A nrPDB Length = 386 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 74/305 (24%), Positives = 128/305 (41%), Gaps = 27/305 (8%) Query: 5 SQFKQLEKLGNGTYATVYKG------LNKTTGV-YVALKEVKLDSEEGTPSTAIREISLM 57 + + LG G + V +K V VA+K +K D+ E S I E+ +M Sbjct: 40 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 99 Query: 58 KEL-KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTV----------GNTPRGL 105 K + KH+NI+ L + L ++ E+ +L++Y+ +R N L Sbjct: 100 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQL 159 Query: 106 ELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF 165 + +Q+ +G+ + K +HRDL +N+L+ + +K+ DFGLAR Sbjct: 160 SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYK 219 Query: 166 SSEVV--TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIF 222 + + + AP+ L R Y+ D+WS G +L E+ T G +PG EE KL+ Sbjct: 220 KTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 278 Query: 223 DIMGTPNESLWPSVTKL---PKYNPNIQQRPP-RDLRQVLQPHTKEPLDGNLMDFLHGLL 278 + S + + ++ QRP + L + L + +D L Sbjct: 279 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLD 338 Query: 279 QLNPD 283 Q +P Sbjct: 339 QYSPS 343 >2XYN-A nrPDB Length = 292 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 65/282 (23%), Positives = 114/282 (40%), Gaps = 43/282 (15%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 KLG G Y VY G+ K + VA+K +K D+ E ++E ++MKE+KH N+V+L V Sbjct: 39 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME--VEEFLKEAAVMKEIKHPNLVQLLGV 96 Query: 72 IHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 E +V E+M +L Y+ + ++ Y Q+ + + + + Sbjct: 97 CTLEPPFYIVTEYMPYGNLLDYLRECNREE----VTAVVLLYMATQISSAMEYLEKKNFI 152 Query: 131 HRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT-FSSEVVTLWYRAPDVLMGSRTYSTS 189 HRDL +N L+ + +K+ DFGL+R T + + + AP+ L T+S Sbjct: 153 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL-AYNTFSIK 211 Query: 190 IDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQ 248 D+W+ G +L E+ T G +PG + + L+ P Sbjct: 212 SDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP-------------- 257 Query: 249 RPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 + + + + +P R S + Sbjct: 258 -------------------PKVYELMRACWKWSPADRPSFAE 280 >2H8H-A nrPDB Length = 535 Score = 220 bits (562), Expect = 4e-58, Method: Composition-based stats. Identities = 70/293 (23%), Positives = 123/293 (41%), Gaps = 47/293 (16%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 KLG G + V+ G T VA+K +K + +P ++E +MK+L+HE +V+LY V Sbjct: 274 KLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTM--SPEAFLQEAQVMKKLRHEKLVQLYAV 330 Query: 72 IHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 + +E + +V E+M L ++ G T + L L + Q+ G+A+ + Sbjct: 331 V-SEEPIYIVTEYMSKGSLLDFLK----GETGKYLRLPQLVDMAAQIASGMAYVERMNYV 385 Query: 131 HRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWYRAPDVLMGSRTYSTS 189 HRDL+ N+L+ + K+ DFGLAR + + AP+ + R ++ Sbjct: 386 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR-FTIK 444 Query: 190 IDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQ 248 D+WS G +L E+ T G+ +PG + E L + P P Sbjct: 445 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-------------- 490 Query: 249 RPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 +L D + + P+ R + + L + +Y+ Sbjct: 491 -------------------ESLHDLMCQCWRKEPEERPTF-EYLQ-AFLEDYF 522 >2Y6O-A nrPDB Length = 291 Score = 220 bits (562), Expect = 4e-58, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 124/292 (42%), Gaps = 27/292 (9%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVY---VALKEVKLDSEEGTPSTAIREISLMKE 59 +S K + +G G + V G K G VA+K +K + + E S+M + Sbjct: 12 DASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQ 71 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H NI+ L V+ + ++ E+M+N +D+ N R + LV + Sbjct: 72 FDHPNIIHLEGVVTKCKPVMIITEYMENG---SLDAFLRKNDGRFTVIQLVG-MLRGIGS 127 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV---TLWYRA 176 G+ + + +HRDL +N+L+N K+ DFG++R + + + A Sbjct: 128 GMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTA 187 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 P+ + R ++++ D+WS G ++ E+++ G+ + ++++ +K I + P P Sbjct: 188 PEAI-AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPI 246 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPD--MR 285 + ++R R P G +++ L L NP+ R Sbjct: 247 ALHQLMLDCWQKERSDR------------PKFGQIVNMLDK-LIRNPNSLKR 285 >1VZO-A nrPDB Length = 355 Score = 220 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 65/315 (20%), Positives = 124/315 (39%), Gaps = 59/315 (18%) Query: 5 SQFKQLEKLGNGTYATVYKGLN---KTTGVYVALKEVKLDS---EEGTPSTAIREISLMK 58 F+ L+ LG G Y V+ TG A+K +K + + T E +++ Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 59 ELK-HENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 ++ +V L+ TE KL L+ ++++ L ++ R + V+ + + Sbjct: 114 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRER------FTEHEVQIYVGE 167 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS-SEVVTLWYR 175 ++ L H+ I++RD+K +N+L++ G + L DFGL++ F + T+ Y Sbjct: 168 IVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYM 227 Query: 176 APDVLM-GSRTYSTSIDIWSCGCILAEMITGKPLF----PGTNDEEQLKLIFDIMGTPNE 230 APD++ G + ++D WS G ++ E++TG F + E + I Sbjct: 228 APDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILK------- 280 Query: 231 SLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL---- 286 +P + + D + LL +P RL Sbjct: 281 ---------------------------SEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGP 313 Query: 287 -SAKQALHHPWFAEY 300 A + H +F + Sbjct: 314 RDADEIKEHLFFQKI 328 >5L6P-A nrPDB Length = 298 Score = 220 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 62/258 (24%), Positives = 118/258 (45%), Gaps = 14/258 (5%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVY---VALKEVKLDSEEGTPSTAIREISLMKELK 61 S K E +G G + V +G K G VA+K +K+ E + E S+M + Sbjct: 19 SCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFD 78 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H NI+RL V+ + ++ EFM+N +DS N + + LV + G+ Sbjct: 79 HPNIIRLEGVVTKSRPVMILTEFMEN---CALDSFLRLNDGQFTVIQLVG-MLRGIAAGM 134 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIP--VNTFSSEVV---TLWYRA 176 + E +HRDL +N+L+N K+ DFGL+R T++S + + + A Sbjct: 135 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTA 194 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 P+ + R ++++ D+WS G ++ E+++ G+ + ++++ + + P P+ Sbjct: 195 PEAI-AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPT 253 Query: 236 VTKLPKYNPNIQQRPPRD 253 + ++ R R Sbjct: 254 ALHQLMLDCWVRDRNLRP 271 >6F3F-A nrPDB Length = 455 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 70/293 (23%), Positives = 124/293 (42%), Gaps = 47/293 (16%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 KLG G + V+ G T VA+K +K + +P ++E +MK+L+HE +V+LY V Sbjct: 194 KLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTM--SPEAFLQEAQVMKKLRHEKLVQLYAV 250 Query: 72 IHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 + +E + +V E+M+ L ++ G T + L L + Q+ G+A+ + Sbjct: 251 V-SEEPIYIVTEYMNKGSLLDFLK----GETGKYLRLPQLVDMSAQIASGMAYVERMNYV 305 Query: 131 HRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWYRAPDVLMGSRTYSTS 189 HRDL+ N+L+ + K+ DFGLAR + + AP+ + R ++ Sbjct: 306 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR-FTIK 364 Query: 190 IDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQ 248 D+WS G +L E+ T G+ +PG + E L + P P Sbjct: 365 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-------------- 410 Query: 249 RPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 +L D + + P+ R + + L + +Y+ Sbjct: 411 -------------------ESLHDLMCQCWRKEPEERPTF-EYLQ-AFLEDYF 442 >4EBW-A nrPDB Length = 304 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 58/293 (19%), Positives = 119/293 (40%), Gaps = 46/293 (15%) Query: 5 SQFKQLEKLGNGTYATVYKGLN---KTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 + + +G G + V++G+ + + VA+K K + + ++E M++ Sbjct: 38 ERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFD 97 Query: 62 HENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H +IV+L VI TEN + ++ E +L+ ++ R L+L + + +QL Sbjct: 98 HPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKY-----SLDLASLILYAYQLSTA 151 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE-VVTLWYRAPDV 179 LA+ + +HRD+ +N+L++ +KLGDFGL+R +S+ + + + AP+ Sbjct: 152 LAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPES 211 Query: 180 LMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 + R ++++ D+W G + E++ G F G + + + I + P P Sbjct: 212 I-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP---- 266 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 L + +P R + Sbjct: 267 -----------------------------PTLYSLMTKCWAYDPSRRPRFTEL 290 >3TT0-A nrPDB Length = 382 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 118/311 (37%), Gaps = 56/311 (18%) Query: 5 SQFKQLEKLGNGTYATVYKG------LNKTTGV-YVALKEVKLDSEEGTPSTAIREISLM 57 + + LG G + V +K V VA+K +K D+ E S I E+ +M Sbjct: 69 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 128 Query: 58 KEL-KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTV----------GNTPRGL 105 K + KH+NI+ L + L ++ E+ +L++Y+ +R N L Sbjct: 129 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQL 188 Query: 106 ELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF 165 + +Q+ +G+ + K +HRDL +N+L+ + +K+ DFGLAR Sbjct: 189 SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYK 248 Query: 166 SSEVV--TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIF 222 + + + AP+ L R Y+ D+WS G +L E+ T G +PG EE KL+ Sbjct: 249 KTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 307 Query: 223 DIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNP 282 + S L + P Sbjct: 308 EGHRMDKPSNC---------------------------------TNELYMMMRDCWHAVP 334 Query: 283 DMRLSAKQALH 293 R + KQ + Sbjct: 335 SQRPTFKQLVE 345 >2R2P-A nrPDB Length = 295 Score = 220 bits (560), Expect = 7e-58, Method: Composition-based stats. Identities = 58/288 (20%), Positives = 117/288 (40%), Gaps = 27/288 (9%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVY---VALKEVKLDSEEGTPSTAIREISLMKEL 60 +S +G G + V G K G VA+K +K+ E + E S+M + Sbjct: 21 ASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQF 80 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H NI+ L V+ + +V E+M+ L ++ + + + Sbjct: 81 DHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQ-----FTVIQLVGMLRGISA 135 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV---TLWYRA 176 G+ + + +HRDL +N+LIN K+ DFGL+R + + + A Sbjct: 136 GMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTA 195 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 P+ + R ++++ D+WS G ++ E+++ G+ + +++ +K + + P+ P+ Sbjct: 196 PEAI-AFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPA 254 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPD 283 + ++R R P +++ L L NP Sbjct: 255 ALYQLMLDCWQKERNSR------------PKFDEIVNMLDK-LIRNPA 289 >3DKO-A nrPDB Length = 318 Score = 220 bits (560), Expect = 8e-58, Method: Composition-based stats. Identities = 56/240 (23%), Positives = 109/240 (45%), Gaps = 12/240 (5%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVY---VALKEVKLDSEEGTPSTAIREISLMKE 59 +S K +G G + V G K G VA+K +K+ E + E S+M + Sbjct: 41 DASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQ 100 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H N+V L V+ + +V EFM+N +D+ + + + LV + Sbjct: 101 FDHPNVVHLEGVVTRGKPVMIVIEFMENGA---LDAFLRKHDGQFTVIQLVG-MLRGIAA 156 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV---TLWYRA 176 G+ + + +HRDL +N+L+N K+ DFGL+R + + + A Sbjct: 157 GMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTA 216 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 P+ + R ++++ D+WS G ++ E+++ G+ + ++++ +K I + P P+ Sbjct: 217 PEAIQ-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPA 275 >4AN9-A nrPDB Length = 301 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 72/297 (24%), Positives = 127/297 (42%), Gaps = 43/297 (14%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 F+++ +LG G V+K +K +G+ +A K + L+ + + IRE+ ++ E Sbjct: 8 DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 67 Query: 64 NIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 IV Y +++ ++++ E MD L + + + ++ +++GL Sbjct: 68 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR------IPEQILGKVSIAVIKGLT 121 Query: 123 FC-HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 + ++KI+HRD+KP N+L+N RG++KL DFG++ + V T Y +P+ L Sbjct: 122 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDEMANEFVGTRSYMSPERLQ 179 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 G+ YS DIWS G L EM G+ +L+ I+ P L +V Sbjct: 180 GT-HYSVQSDIWSMGLSLVEMAVGRYP---RPPMAIFELLDYIVNEPPPKLPSAV----- 230 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 DF++ L NP R KQ + H + Sbjct: 231 ------------------------FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 263 >4MD7-E nrPDB Length = 391 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 82/304 (26%), Positives = 158/304 (51%), Gaps = 21/304 (6%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 + ++ + KLG G Y+ V++ +N T V + REI +++ L+ Sbjct: 34 GNQDDYQLVRKLGRGKYSEVFEAINITNNEK----VVVKILKPVKKKKIKREIKILENLR 89 Query: 62 H-ENIVRLYDVIHTENKLT--LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 NI+ L D++ T LVFE ++N K + + L ++++ +++L Sbjct: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL--------YQTLTDYDIRFYMYEIL 141 Query: 119 QGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + L +CH I+HRD+KP N++I+ + +L+L D+GLA F P ++ V + +++ P Sbjct: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGP 200 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 ++L+ + Y S+D+WS GC+LA MI K P F G ++ +QL I ++GT + + Sbjct: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 260 Query: 237 TKL---PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 + P++N + + + + + + + +DFL LL+ + RL+A++A+ Sbjct: 261 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 320 Query: 294 HPWF 297 HP+F Sbjct: 321 HPYF 324 >3GQL-A nrPDB Length = 326 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 71/295 (24%), Positives = 124/295 (42%), Gaps = 27/295 (9%) Query: 5 SQFKQLEKLGNGTYATVYKG------LNKTTGV-YVALKEVKLDSEEGTPSTAIREISLM 57 + + LG G + V +K V VA+K +K D+ E S I E+ +M Sbjct: 28 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 87 Query: 58 KEL-KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTV----------GNTPRGL 105 K + KH+NI+ L + L ++ E+ +L++Y+ +R N L Sbjct: 88 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQL 147 Query: 106 ELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF 165 + +Q+ +G+ + K +HRDL +N+L+ + +K+ DFGLAR Sbjct: 148 SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYK 207 Query: 166 SSEVV--TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIF 222 + + + AP+ L R Y+ D+WS G +L E+ T G +PG EE KL+ Sbjct: 208 KTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK 266 Query: 223 DIMGTPNESLWPSVTKL---PKYNPNIQQRPP-RDLRQVLQPHTKEPLDGNLMDF 273 + S + + ++ QRP + L + L + +D Sbjct: 267 EGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDL 321 >1JPA-A nrPDB Length = 312 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 65/288 (22%), Positives = 126/288 (43%), Gaps = 27/288 (9%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVY---VALKEVKLDSEEGTPSTAIREISLMKELK 61 S K + +G G + V G K G VA+K +K E + E S+M + Sbjct: 33 SCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFD 92 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H N++ L V+ + ++ EFM+N +DS N + + LV + G+ Sbjct: 93 HPNVIHLEGVVTKSTPVMIITEFMENG---SLDSFLRQNDGQFTVIQLVG-MLRGIAAGM 148 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN--TFSSEVV---TLWYRA 176 + + +HRDL +N+L+N K+ DFGL+R + T++S + + + A Sbjct: 149 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 208 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 P+ + R ++++ D+WS G ++ E+++ G+ + +++ + I P PS Sbjct: 209 PEAIQ-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPS 267 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPD 283 + + R R P G +++ L +++ NP+ Sbjct: 268 ALHQLMLDCWQKDRNHR------------PKFGQIVNTLDKMIR-NPN 302 >4XLV-A nrPDB Length = 328 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 71/316 (22%), Positives = 121/316 (38%), Gaps = 53/316 (16%) Query: 3 SSSQFKQLEKLGNGTYATVYKG--LNKTTGV---YVALKEVKLDSEEGTPSTAIREISLM 57 S + L +LG G++ VY+G + G VA+K V + + E S+M Sbjct: 37 SREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVM 96 Query: 58 KELKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTP----RGLELNLVKY 112 K ++VRL V+ +V E M DLK Y+ S L + Sbjct: 97 KGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQ 156 Query: 113 FQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-- 170 ++ G+A+ + K +HRDL +N ++ +K+GDFG+ R Sbjct: 157 MAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLL 216 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPN 229 + + AP+ L ++TS D+WS G +L E+ + + + G ++E+ LK + D Sbjct: 217 PVRWMAPESLKDG-VFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQ 275 Query: 230 ESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 P + D + Q NP+MR + Sbjct: 276 PDNCP---------------------------------ERVTDLMRMCWQFNPNMRPTFL 302 Query: 290 QALH------HPWFAE 299 + ++ HP F E Sbjct: 303 EIVNLLKDDLHPSFPE 318 >3VN9-A nrPDB Length = 340 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 64/307 (20%), Positives = 123/307 (40%), Gaps = 39/307 (12%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISL-MKELKH 62 + + + +LG G Y V K + +G +A+K ++ + ++ + M+ + Sbjct: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 V Y + E + + E MD L K+ + V + + + +++ +++ L Sbjct: 110 PFTVTFYGALFREGDVWICMELMDTSLDKF--YKQVIDKGQTIPEDILGKIAVSIVKALE 167 Query: 123 FCHEN-KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL- 180 H ++HRD+KP N+LIN GQ+K+ DFG++ V + + Y AP+ + Sbjct: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK-TIDAGCKPYMAPERIN 226 Query: 181 --MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 + + YS DIWS G + E+ L+ +D GTP + L V + Sbjct: 227 PELNQKGYSVKSDIWSLGITMIELA-------------ILRFPYDSWGTPFQQLKQVVEE 273 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 P + +DF L+ N R + + + HP+F Sbjct: 274 PSPQLP------------------ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 Query: 299 EYYHHAS 305 + + Sbjct: 316 LHESKGT 322 >2DQ7-X nrPDB Length = 283 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 129/298 (43%), Gaps = 47/298 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 + +++LGNG + V+ G VA+K +K + +P + + E +MK+LKH+ +V Sbjct: 11 LQLIKRLGNGQFGEVWMGTW-NGNTKVAIKTLKPGTM--SPESFLEEAQIMKKLKHDKLV 67 Query: 67 RLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 +LY V+ +E + +V E+M+ L ++ R L+L + Q+ G+A+ Sbjct: 68 QLYAVV-SEEPIYIVTEYMNKGSLLDFLKD----GEGRALKLPNLVDMAAQVAAGMAYIE 122 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWYRAPDVLMGSR 184 +HRDL+ N+L+ K+ DFGLAR + + AP+ + R Sbjct: 123 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 182 Query: 185 TYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 ++ D+WS G +L E++T G+ +PG N+ E L+ + P P Sbjct: 183 -FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCP--------- 232 Query: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 +L + + + +P+ R + + L + +Y+ Sbjct: 233 ------------------------ISLHELMIHCWKKDPEERPTF-EYLQ-SFLEDYF 264 >3PPZ-A nrPDB Length = 309 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 115/291 (39%), Gaps = 42/291 (14%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHEN 64 EK+G G++ TV++ G VA+K + + D + +RE+++MK L+H N Sbjct: 38 DLNIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPN 95 Query: 65 IVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 IV + L++V E++ L + + L+ + + +G+ + Sbjct: 96 IVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQ---LDERRRLSMAYDVAKGMNY 152 Query: 124 CHENK--ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 H I+HRDLK NLL++K+ +K+ DFGL+R + S T + AP+VL Sbjct: 153 LHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLR 212 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 + + D++S G IL E+ T + + N + + + Sbjct: 213 DEPS-NEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVG------------------- 252 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 + + L+ + + G P R S + Sbjct: 253 -------------FKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIM 290 >6FEX-A nrPDB Length = 321 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 59/323 (18%), Positives = 127/323 (39%), Gaps = 57/323 (17%) Query: 5 SQFKQLEKLGNGTYATVYKG----------------LNKTTGVYVALKEVKLDSEEGTPS 48 S+ + EKLG G + V+ + K + VA+K ++ D+ + + Sbjct: 16 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARN 75 Query: 49 TAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTP----- 102 ++E+ +M LK NI+RL V ++ L ++ ++M+ DL +++ + + + Sbjct: 76 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAP 135 Query: 103 --RGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF-- 158 + ++ + Q+ G+ + +HRDL +N L+ + +K+ DFG++R Sbjct: 136 GDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYA 195 Query: 159 GIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAE--MITGKPLFPGTNDEE 216 G V+ + + A + ++ + ++T+ D+W+ G L E M+ F DE+ Sbjct: 196 GDYYRVQGRAVLPIRWMAWECILMGK-FTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQ 254 Query: 217 QLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHG 276 ++ + RD + + L + + Sbjct: 255 VIENAGEFF--------------------------RDQGRQVYLSRPPACPQGLYELMLR 288 Query: 277 LLQLNPDMRLSAKQALHHPWFAE 299 + R Q H + AE Sbjct: 289 CWSRESEQRPPFSQL--HRFLAE 309 >6GQK-A nrPDB Length = 328 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 64/310 (20%), Positives = 114/310 (36%), Gaps = 55/310 (17%) Query: 5 SQFKQLEKLGNGTYATVYKG-----LNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKE 59 ++ + LG G + V + + + VA+K +K + + E+ ++ Sbjct: 41 NRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSY 100 Query: 60 L-KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTP----------RGLEL 107 L HENIV L ++ E+ DL ++ + P L L Sbjct: 101 LGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTL 160 Query: 108 NLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS- 166 + F +Q+ +G+AF +HRDL +N+L+ K+ DFGLAR N Sbjct: 161 EHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDK 220 Query: 167 -SEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTN-DEEQLKLIFD 223 + + + + AP+ + S Y+ D+WS G L E+ + G +PG D + K+I + Sbjct: 221 GNARLPVKWMAPESIFNS-VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKE 279 Query: 224 IMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPD 283 + P + D + +PD Sbjct: 280 GFRMSSPEYAP---------------------------------AEMYDIMKTCWDADPD 306 Query: 284 MRLSAKQALH 293 R + KQ + Sbjct: 307 KRPTFKQIVQ 316 >4AT3-A nrPDB Length = 299 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 62/262 (23%), Positives = 120/262 (45%), Gaps = 23/262 (8%) Query: 9 QLEKLGNGTYATVYKGLN-----KTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 +LG G + V+ + + VA+K +K D+ + RE L+ L+HE Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-DASDNARKDFHREAELLTNLQHE 75 Query: 64 NIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTV-------GNTPRGLELNLVKYFQW 115 +IV+ Y V + L +VFE+M DL K++ + GN P L + + + Sbjct: 76 HIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQ 135 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSS--EVVTLW 173 Q+ G+ + +HRDL +N L+ + +K+GDFG++R ++ + Sbjct: 136 QIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIR 195 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDI-----MGT 227 + P+ +M R ++T D+WS G +L E+ T GK + ++ E ++ I T Sbjct: 196 WMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRT 254 Query: 228 PNESLWPSVTKLPKYNPNIQQR 249 + ++ + + P++++ Sbjct: 255 CPQEVYELMLGCWQREPHMRKN 276 >5H2U-A nrPDB Length = 267 Score = 217 bits (554), Expect = 3e-57, Method: Composition-based stats. Identities = 76/269 (28%), Positives = 127/269 (47%), Gaps = 13/269 (4%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 +F KLG+G + V++GL K V VA+K + D+ EI MK+L+H++ Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKDR-VQVAIKVISRDNL-LHQQMLQSEIQAMKKLRHKH 63 Query: 65 IVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 I+ LY V+ + + ++ E M L + + + + L ++ + WQ+ +G+ + Sbjct: 64 ILALYAVVSVGDPVYIITELMAKGSLLELLRD----SDEKVLPVSELLDIAWQVAEGMCY 119 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 +HRDL +N+L+ + K+GDFGLAR V + + AP+ L Sbjct: 120 LESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL-SR 178 Query: 184 RTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNE-SLWPSVTK--L 239 YST D+WS G +L EM + G+ +PG ++ E + P PSV K L Sbjct: 179 GHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLML 238 Query: 240 PKYNPNIQQRPP-RDLRQVLQPHTKEPLD 267 + + +QRP + LR+ L T Sbjct: 239 TCWCRDPEQRPTFKALRERLSSFTSHHHH 267 >2BRG-A nrPDB Length = 297 Score = 217 bits (554), Expect = 3e-57, Method: Composition-based stats. Identities = 71/297 (23%), Positives = 118/297 (39%), Gaps = 38/297 (12%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 + ++ LG G Y V +N+ T VA+K V + P +EI + K L HEN Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHEN 66 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 +V+ Y N L E+ + G+ + F QL+ G+ + Sbjct: 67 VVKFYGHRREGNIQYLFLEYCSGG-----ELFDRIEPDIGMPEPDAQRFFHQLMAGVVYL 121 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAF--GIPVNTFSSEVVTLWYRAPDVLMG 182 H I HRD+KP+NLL+++R LK+ DFGLA F + TL Y AP++L Sbjct: 122 HGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKR 181 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 ++ +D+WSCG +L M+ G+ + PS + Sbjct: 182 REFHAEPVDVWSCGIVLTAMLAGELPW----------------------DQPSDSCQEYS 219 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + ++ +++ LH +L NP R++ W+ + Sbjct: 220 DWKEKKTYLNPWKKIDSAPLA---------LLHKILVENPSARITIPDIKKDRWYNK 267 >2J0K-A nrPDB Length = 656 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 58/293 (19%), Positives = 119/293 (40%), Gaps = 46/293 (15%) Query: 5 SQFKQLEKLGNGTYATVYKGLN---KTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 + + +G G + V++G+ + + VA+K K + + ++E M++ Sbjct: 390 ERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFD 449 Query: 62 HENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H +IV+L VI TEN + ++ E +L+ ++ R L+L + + +QL Sbjct: 450 HPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKF-----SLDLASLILYAYQLSTA 503 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE-VVTLWYRAPDV 179 LA+ + +HRD+ +N+L++ +KLGDFGL+R +S+ + + + AP+ Sbjct: 504 LAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPES 563 Query: 180 LMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 + R ++++ D+W G + E++ G F G + + + I + P P Sbjct: 564 I-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP---- 618 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 L + +P R + Sbjct: 619 -----------------------------PTLYSLMTKCWAYDPSRRPRFTEL 642 >5DYK-A nrPDB Length = 853 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 74/305 (24%), Positives = 126/305 (41%), Gaps = 49/305 (16%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELK 61 + + +G GT+ TV +K T + ALK V S + E + E Sbjct: 538 MDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAEND 597 Query: 62 HENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H I+RL + E + +L + + L + +++ ++ Sbjct: 598 HPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGL------LSKSQAQFYLGSIILA 651 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 + + HE I++RDLKP+N+L++K+G +KL DFG A+ T V T Y AP+V+ Sbjct: 652 IEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTL---VGTPHYMAPEVI 708 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 +G + Y ++DIW+ G L E I G F G ++E+QL++ DI+ P Sbjct: 709 LG-KGYGCTVDIWALGICLYEFICGPLPF-GNDEEDQLEIFRDILT--------GQLTFP 758 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA-----KQALHHP 295 Y D + ++ + LL P R+ K HP Sbjct: 759 DYV----------------------TDTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHP 796 Query: 296 WFAEY 300 +F+ + Sbjct: 797 FFSNF 801 >4XCU-A nrPDB Length = 300 Score = 217 bits (553), Expect = 5e-57, Method: Composition-based stats. Identities = 65/302 (21%), Positives = 120/302 (39%), Gaps = 47/302 (15%) Query: 5 SQFKQLEKLGNGTYATVYKGL-------NKTTGVYVALKEVKLDSEEGTPSTAIREISLM 57 + + LG G + V + VA+K +K ++ + + + E+ +M Sbjct: 17 DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVM 76 Query: 58 KEL-KHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRG-LELNLVKYFQ 114 K + +H+NI+ L V E L ++ E +L++++ +R + G L ++ Sbjct: 77 KLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCA 136 Query: 115 WQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV--TL 172 +Q+ +G+ + K +HRDL +N+L+ + +K+ DFGLAR + + Sbjct: 137 YQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPV 196 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNES 231 + AP+ L R Y+ D+WS G +L E+ T G +PG EE L+ + Sbjct: 197 KWMAPEALFD-RVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREG------- 248 Query: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 + RPP L + P R + KQ Sbjct: 249 -------------HRMDRPPH-------------CPPELYGLMRECWHAAPSQRPTFKQL 282 Query: 292 LH 293 + Sbjct: 283 VE 284 >6BDL-A nrPDB Length = 347 Score = 217 bits (553), Expect = 5e-57, Method: Composition-based stats. Identities = 70/303 (23%), Positives = 121/303 (39%), Gaps = 49/303 (16%) Query: 5 SQFKQLEKLGNGTYATVYKGLNK-TTGVYVALKEVKLD--SEEGTPSTAIREISLMKELK 61 S F ++ LG G + V K A+K +K + E +M+ Sbjct: 34 SDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAH 93 Query: 62 HENIVRLYDVIHTENKLTLVFE-FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 + IVRLY L ++ E + +L + R E + +++ +++ Sbjct: 94 SDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRG------SFEDSTTRFYTACVVEA 147 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 A+ H I++RDLKP+NL+++ RG KL DFG A+ G T++ T Y AP+++ Sbjct: 148 FAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWT-FCGTPEYVAPEII 206 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 + + + S D WS G ++ E++TG P F G + + +I + + + P Sbjct: 207 LN-KGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGI---------DMIEFP 256 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALHHP 295 K + N + + L + NP RL K H Sbjct: 257 K-----------------------KIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHK 293 Query: 296 WFA 298 WF Sbjct: 294 WFE 296 >6HMD-A nrPDB Length = 365 Score = 217 bits (552), Expect = 6e-57, Method: Composition-based stats. Identities = 84/306 (27%), Positives = 157/306 (51%), Gaps = 25/306 (8%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 + ++ + KLG G Y+ V++ +N T V + RE+ +++ L+ Sbjct: 50 GNQDDYQLVRKLGRGKYSEVFEAINITNNER----VVVKILKPVKKKKIKREVKILENLR 105 Query: 62 H-ENIVRLYDVIHTE--NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 NI++L D + LVFE+++N K + + L ++++ ++LL Sbjct: 106 GGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL--------YQILTDFDIRFYMYELL 157 Query: 119 QGLAFCHENKILHRDLKPQNLLINKR-GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + L +CH I+HRD+KP N++I+ + +L+L D+GLA F P ++ V + +++ P Sbjct: 158 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGP 216 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 ++L+ + Y S+D+WS GC+LA MI + P F G ++ +QL I ++GT E L+ + Sbjct: 217 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT--EELYGYL 274 Query: 237 TKL-----PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 K P +N + Q + + + + +D L LL+ + RL+AK+A Sbjct: 275 KKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 334 Query: 292 LHHPWF 297 + HP+F Sbjct: 335 MEHPYF 340 >1NY3-A nrPDB Length = 400 Score = 217 bits (552), Expect = 7e-57, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 116/304 (38%), Gaps = 46/304 (15%) Query: 5 SQFKQ-LEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLM-KELKH 62 +K + LG G V + NK T ALK + A RE+ L + + Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQC 114 Query: 63 ENIVRLYDVIHT----ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 +IVR+ DV L +V E +D + SR + + Sbjct: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGG---ELFSRIQDRGDQAFTEREASEIMKSIG 171 Query: 119 QGLAFCHENKILHRDLKPQNLLINK---RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 + + + H I HRD+KP+NLL LKL DFG A+ N+ ++ T +Y Sbjct: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYV 230 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 AP+VL G Y S D+WS G I+ ++ G P F + Sbjct: 231 APEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAI------------------ 271 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 +P ++ R + P E + + + LL+ P R++ + ++HP Sbjct: 272 -------SPGMKTRIRMGQYEFPNPEWSE-VSEEVKMLIRNLLKTEPTQRMTITEFMNHP 323 Query: 296 WFAE 299 W + Sbjct: 324 WIMQ 327 >2PVN-A nrPDB Length = 352 Score = 216 bits (551), Expect = 8e-57, Method: Composition-based stats. Identities = 78/305 (25%), Positives = 152/305 (49%), Gaps = 19/305 (6%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 ++ + K+G G Y+ V++G+N +K+ L Sbjct: 49 GEQDDYEVVRKVGRGKYSEVFEGINVNNNEKC---IIKILKPVKKKKIKREIKILQNLCG 105 Query: 62 HENIVRLYDVIHTENKLT--LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 NIV+L D++ ++ T L+FE+++N K + L ++Y+ ++LL+ Sbjct: 106 GPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVL--------YPTLTDYDIRYYIYELLK 157 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQ-LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 L +CH I+HRD+KP N++I+ + L+L D+GLA F P ++ V + +++ P+ Sbjct: 158 ALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLA-EFYHPGKEYNVRVASRYFKGPE 216 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 +L+ + Y S+D+WS GC+ A MI K P F G ++ +QL I ++GT + + + Sbjct: 217 LLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKY 276 Query: 238 KL---PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 ++ P+ + + + + + + + +DFL LL+ + RL+A +A+ H Sbjct: 277 RIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTH 336 Query: 295 PWFAE 299 P+F + Sbjct: 337 PYFQQ 341 >2PSQ-A nrPDB Length = 370 Score = 216 bits (551), Expect = 8e-57, Method: Composition-based stats. Identities = 68/311 (21%), Positives = 120/311 (38%), Gaps = 56/311 (18%) Query: 5 SQFKQLEKLGNGTYATVYK----GLNKTTGVY---VALKEVKLDSEEGTPSTAIREISLM 57 + + LG G + V G++K VA+K +K D+ E S + E+ +M Sbjct: 81 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 140 Query: 58 KEL-KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLV----- 110 K + KH+NI+ L + L ++ E+ +L++Y+ +R ++N V Sbjct: 141 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 200 Query: 111 -----KYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF 165 +QL +G+ + K +HRDL +N+L+ + +K+ DFGLAR Sbjct: 201 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 260 Query: 166 SSEVV--TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIF 222 + + + AP+ L R Y+ D+WS G ++ E+ T G +PG EE KL+ Sbjct: 261 KTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 319 Query: 223 DIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNP 282 + + L + P Sbjct: 320 EGHRMDKPANC---------------------------------TNELYMMMRDCWHAVP 346 Query: 283 DMRLSAKQALH 293 R + KQ + Sbjct: 347 SQRPTFKQLVE 357 >5SYS-A nrPDB Length = 286 Score = 216 bits (551), Expect = 8e-57, Method: Composition-based stats. Identities = 68/293 (23%), Positives = 122/293 (41%), Gaps = 47/293 (16%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 KLG G + + G T VA+K +K + +P ++E +MK+L+HE +V+LY V Sbjct: 25 KLGQGCFGECWMGTWNGT-TRVAIKTLKPGTM--SPEAFLQEAQVMKKLRHEKLVQLYAV 81 Query: 72 IHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 + +E + +V E+M L ++ G + L L + Q+ G+A+ + Sbjct: 82 V-SEEPIYIVTEYMSKGSLLDFLK----GEMGKYLRLPQLVDMAAQIASGMAYVERMNYV 136 Query: 131 HRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWYRAPDVLMGSRTYSTS 189 HRDL+ N+L+ + K+ DFGLAR + + AP+ + R ++ Sbjct: 137 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR-FTIK 195 Query: 190 IDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQ 248 D+WS G +L E+ T G+ +PG + E L + P P Sbjct: 196 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-------------- 241 Query: 249 RPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 +L D + + +P+ R + + L + +Y+ Sbjct: 242 -------------------ESLHDLMCQCWRKDPEERPTF-EYLQ-AFLEDYF 273 >6BSD-A nrPDB Length = 876 Score = 216 bits (551), Expect = 8e-57, Method: Composition-based stats. Identities = 59/329 (17%), Positives = 127/329 (38%), Gaps = 63/329 (19%) Query: 5 SQFKQLEKLGNGTYATVYKG----------------LNKTTGVYVALKEVKLDSEEGTPS 48 S+ + EKLG G + V+ + K + VA+K ++ D+ + + Sbjct: 571 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARN 630 Query: 49 TAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNT------ 101 ++E+ +M LK NI+RL V ++ L ++ ++M+ DL +++ + + + Sbjct: 631 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAP 690 Query: 102 -------PRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGL 154 + ++ + Q+ G+ + +HRDL +N L+ + +K+ DFG+ Sbjct: 691 GDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGM 750 Query: 155 ARAF--GIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAE--MITGKPLFP 210 +R G V+ + + A + ++ + ++T+ D+W+ G L E M+ F Sbjct: 751 SRNLYAGDYYRVQGRAVLPIRWMAWECILMGK-FTTASDVWAFGVTLWEVLMLCRAQPFG 809 Query: 211 GTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNL 270 DE+ ++ + RD + + L Sbjct: 810 QLTDEQVIENAGEFF--------------------------RDQGRQVYLSRPPACPQGL 843 Query: 271 MDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + + + R Q H + AE Sbjct: 844 YELMLRCWSRESEQRPPFSQL--HRFLAE 870 >3PFQ-A nrPDB Length = 674 Score = 216 bits (551), Expect = 8e-57, Method: Composition-based stats. Identities = 56/241 (23%), Positives = 107/241 (44%), Gaps = 11/241 (4%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKE-LK 61 + F L LG G++ V K T A+K +K D ++ + E ++ K Sbjct: 341 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 400 Query: 62 HENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 + +L+ T ++L V E++ DL ++ P ++ ++ G Sbjct: 401 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP------HAVFYAAEIAIG 454 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 L F I++RDLK N++++ G +K+ DFG+ + T + T Y AP+++ Sbjct: 455 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 514 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 + Y S+D W+ G +L EM+ G+ F G +++E + I + +S+ + Sbjct: 515 -AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 573 Query: 241 K 241 K Sbjct: 574 K 574 >3TKU-A nrPDB Length = 433 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 58/305 (19%), Positives = 107/305 (35%), Gaps = 46/305 (15%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKL--DSEEGTPSTAIREISLMKELKH 62 F+ ++ +G G + V K T A+K + + + E ++ Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 63 ENIVRLYDVIHTENKLTLVFEF-MDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 + I L+ EN L LV ++ + DL + L ++ +++ +++ + Sbjct: 150 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKF-----EDKLPEDMARFYIGEMVLAI 204 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSS-EVVTLWYRAPDVL 180 H+ +HRD+KP N+L++ G ++L DFG SS V T Y +P++L Sbjct: 205 DSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEIL 264 Query: 181 M----GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 G Y D WS G + EM+ G+ F + E I + Sbjct: 265 QAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN------------- 311 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL---SAKQALH 293 + P + D + L + + RL + Sbjct: 312 ----------------HEERFQFPSHVTDVSEEAKDLIQR-LICSRERRLGQNGIEDFKK 354 Query: 294 HPWFA 298 H +F Sbjct: 355 HAFFE 359 >4K33-A nrPDB Length = 325 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 67/313 (21%), Positives = 123/313 (39%), Gaps = 56/313 (17%) Query: 3 SSSQFKQLEKLGNGTYATVYK----GLNKTTG---VYVALKEVKLDSEEGTPSTAIREIS 55 S ++ + LG G + V G++K V VA+K +K D+ + S + E+ Sbjct: 34 SRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME 93 Query: 56 LMKEL-KHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVG----------NTPR 103 +MK + KH+NI+ L L ++ E+ +L++++ +R Sbjct: 94 MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEE 153 Query: 104 GLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFG--IP 161 L + +Q+ +G+ + K +HRDL +N+L+ + +K+ DFGLAR Sbjct: 154 QLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDY 213 Query: 162 VNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKL 220 ++ + + + AP+ L R Y+ D+WS G +L E+ T G +PG EE KL Sbjct: 214 YKETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKL 272 Query: 221 IFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQL 280 + + + +L + Sbjct: 273 LKEGHRMDKPANC---------------------------------THDLYMIMRECWHA 299 Query: 281 NPDMRLSAKQALH 293 P R + KQ + Sbjct: 300 APSQRPTFKQLVE 312 >4TNB-A nrPDB Length = 590 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 70/302 (23%), Positives = 114/302 (37%), Gaps = 42/302 (13%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKEL 60 + + F+Q LG G + V + TG A K + K + S A+ E +++++ Sbjct: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 + +V L T++ L LV M+ + G E ++ ++L G Sbjct: 242 NSQFVVNLAYAYETKDALCLVLTIMNGG---DLKFHIYNMGNPGFEEERALFYAAEILCG 298 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 L H ++RDLKP+N+L++ G +++ D GLA + V T+ Y AP+VL Sbjct: 299 LEDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIP-EGDLIRGRVGTVGYMAPEVL 357 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 R Y S D W GC++ EMI G+ F G + Sbjct: 358 NNQR-YGLSPDYWGLGCLIYEMIEGQSPFRGRKE-------------------------- 390 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS-----AKQALHHP 295 K R + +V LL + RL A + HP Sbjct: 391 KVKREEVDRRVLETEEV----YSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHP 446 Query: 296 WF 297 +F Sbjct: 447 FF 448 >4PDO-A nrPDB Length = 299 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 62/252 (24%), Positives = 112/252 (44%), Gaps = 15/252 (5%) Query: 11 EKLGNGTYATVYKGLNKTTG----VYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 + +G G + VYKG+ KT+ V VA+K +K E + E +M + H NI+ Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNII 99 Query: 67 RLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 RL VI + ++ E+M+N L K++ + + + + G+ + Sbjct: 100 RLEGVISKYKPMMIITEYMENGALDKFLREKDGE-----FSVLQLVGMLRGIAAGMKYLA 154 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV---TLWYRAPDVLMG 182 +HRDL +N+L+N K+ DFGL+R + + + AP+ + Sbjct: 155 NMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAI-S 213 Query: 183 SRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 R ++++ D+WS G ++ E++T G+ + ++ E +K I D P PS Sbjct: 214 YRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLM 273 Query: 242 YNPNIQQRPPRD 253 Q+R R Sbjct: 274 MQCWQQERARRP 285 >3FME-A nrPDB Length = 290 Score = 215 bits (549), Expect = 1e-56, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 120/300 (40%), Gaps = 39/300 (13%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISL-MKELKH 62 + + + +LG G Y V K + +G +A+K ++ + ++ + M+ + Sbjct: 6 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 65 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 V Y + E + + E MD L K+ + V + + + +++ +++ L Sbjct: 66 PFTVTFYGALFREGDVWICMELMDTSLDKF--YKQVIDKGQTIPEDILGKIAVSIVKALE 123 Query: 123 FCHEN-KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL- 180 H ++HRD+KP N+LIN GQ+K+ DFG++ V + Y AP+ + Sbjct: 124 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAK-DIDAGCKPYMAPERIN 182 Query: 181 --MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 + + YS DIWS G + E+ L+ +D GTP + L V + Sbjct: 183 PELNQKGYSVKSDIWSLGITMIELA-------------ILRFPYDSWGTPFQQLKQVVEE 229 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 P + +DF L+ N R + + + HP+F Sbjct: 230 PSPQLP------------------ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 271 >3KA0-A nrPDB Length = 320 Score = 215 bits (549), Expect = 1e-56, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 115/304 (37%), Gaps = 46/304 (15%) Query: 5 SQFKQ-LEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLM-KELKH 62 +K + LG G V + NK T ALK + A RE+ L + + Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQC 68 Query: 63 ENIVRLYDVIHT----ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 +IVR+ DV L +V E +D + SR + + Sbjct: 69 PHIVRIVDVYENLYAGRKCLLIVMECLDGG---ELFSRIQDRGDQAFTEREASEIMKSIG 125 Query: 119 QGLAFCHENKILHRDLKPQNLLINK---RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 + + + H I HRD+KP+NLL LKL DFG A+ N+ + T +Y Sbjct: 126 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTEPCYTPYYV 184 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 AP+VL G Y S D+WS G I+ ++ G P F + Sbjct: 185 APEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAI------------------ 225 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 +P ++ R + P E + + + LL+ P R++ + ++HP Sbjct: 226 -------SPGMKTRIRMGQYEFPNPEWSE-VSEEVKMLIRNLLKTEPTQRMTITEFMNHP 277 Query: 296 WFAE 299 W + Sbjct: 278 WIMQ 281 >2OZA-A nrPDB Length = 356 Score = 215 bits (549), Expect = 1e-56, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 116/304 (38%), Gaps = 46/304 (15%) Query: 5 SQFKQ-LEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLM-KELKH 62 +K + LG G V + NK T ALK + A RE+ L + + Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQC 70 Query: 63 ENIVRLYDVIHT----ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 +IVR+ DV L +V E +D + SR + + Sbjct: 71 PHIVRIVDVYENLYAGRKCLLIVMECLDGG---ELFSRIQDRGDQAFTEREASEIMKSIG 127 Query: 119 QGLAFCHENKILHRDLKPQNLLINK---RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 + + + H I HRD+KP+NLL LKL DFG A+ N+ ++ T +Y Sbjct: 128 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYV 186 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 AP+VL G Y S D+WS G I+ ++ G P F + Sbjct: 187 APEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAI------------------ 227 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 +P ++ R + P E + + + LL+ P R++ + ++HP Sbjct: 228 -------SPGMKTRIRMGQYEFPNPEWSE-VSEEVKMLIRNLLKTEPTQRMTITEFMNHP 279 Query: 296 WFAE 299 W + Sbjct: 280 WIMQ 283 >4C0T-A nrPDB Length = 974 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 54/307 (17%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKELKH 62 + FK ++LG G+Y+TV +K TG A+K + + +E E + L + Sbjct: 266 TDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSN 325 Query: 63 E-NIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 ++ LY ++ L V ++ +L + L ++F Q+L Sbjct: 326 RLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYN------TLNEECTRHFGAQILDA 379 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT---------FSSEVVT 171 + + H+N ++HRDLKP+N+L++ + ++++ DFG AR + S V T Sbjct: 380 IKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGT 439 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 Y +P++L + D+W+ GCI+ +MI GKP F TN+ + I + + Sbjct: 440 AEYVSPELLEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAG 498 Query: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 +P++ + D + +L L P R + + Sbjct: 499 -FPTI---------------------------------IRDLIKKILVLQPSRRATIPEI 524 Query: 292 LHHPWFA 298 H +F Sbjct: 525 QKHYFFQ 531 >3V5Q-A nrPDB Length = 297 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 70/305 (22%), Positives = 119/305 (39%), Gaps = 54/305 (17%) Query: 6 QFKQLEKLGNGTYATVYKGLN-----KTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 +LG G + V+ + VA+K +K D RE L+ L Sbjct: 16 DIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALK-DPTLAARKDFQREAELLTNL 74 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRT------VGNTPR----GLELNL 109 +HE+IV+ Y V + L +VFE+M DL K++ + V PR L L+ Sbjct: 75 QHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQ 134 Query: 110 VKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSS-- 167 + + Q+ G+ + +HRDL +N L+ +K+GDFG++R Sbjct: 135 MLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGH 194 Query: 168 EVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMG 226 ++ + + P+ +M R ++T D+WS G IL E+ T GK + ++ E ++ I Sbjct: 195 TMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRV 253 Query: 227 TPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL 286 + P + D + G Q P RL Sbjct: 254 LERPRVCP---------------------------------KEVYDVMLGCWQREPQQRL 280 Query: 287 SAKQA 291 + K+ Sbjct: 281 NIKEI 285 >4IAN-A nrPDB Length = 358 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 91/330 (27%), Positives = 150/330 (45%), Gaps = 42/330 (12%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTT-GVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 ++ G G ++ V + + VA+K ++ + E T ++E+ +K+L Sbjct: 29 DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR--NNELMQKTGLKELEFLKKLND 86 Query: 63 E------NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 + +RL+ + + L LVFE + +L++ + GL + V+ + Q Sbjct: 87 ADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYG---KDVGLHIKAVRSYSQQ 143 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQL-KLGDFGLARAFGIPVNTFSSEVVTLWYR 175 L L ILH D+KP N+L+N+ + KL DFG A + N + +V+ +YR Sbjct: 144 LFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSAS--HVADNDITPYLVSRFYR 201 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGT-PNESLWP 234 AP++++G ++Y ID+WS GC L E+ TGK LFPG + LKL D+ G PN+ + Sbjct: 202 APEIIIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRK 260 Query: 235 SVTKLPKYNPNI--------------------QQRPPRDLRQVLQ-----PHTKEPLDGN 269 V K ++ N+ P +DL L P + Sbjct: 261 GVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQ 320 Query: 270 LMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 L D L +L L+P R+S QAL H + E Sbjct: 321 LKDLLDQILMLDPAKRISINQALQHAFIQE 350 >5FET-A nrPDB Length = 847 Score = 214 bits (546), Expect = 3e-56, Method: Composition-based stats. Identities = 74/300 (24%), Positives = 124/300 (41%), Gaps = 49/300 (16%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKHE 63 + + +G GT+ TV +K T + ALK V S + E + E H Sbjct: 534 ELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHP 593 Query: 64 NIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 I+RL N + E + +L + + + P+ +++ ++ + Sbjct: 594 FIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQ------AQFYLGSIILAIE 647 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 + HE I++RDLKP+N+L++K+G +KL DFG A+ T V T Y AP+V++G Sbjct: 648 YLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTL---VGTPHYMAPEVILG 704 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 + Y ++DIW+ G L E I G F G + E+QL++ DI+ P Y Sbjct: 705 -KGYGCTVDIWALGVCLYEFICGPLPF-GNDQEDQLEIFRDILT--------GQLTFPDY 754 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA-----KQALHHPWF 297 D + ++ + LL P R+ K H +F Sbjct: 755 V----------------------SDQDSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFF 792 >2VWV-A nrPDB Length = 302 Score = 214 bits (546), Expect = 3e-56, Method: Composition-based stats. Identities = 63/285 (22%), Positives = 124/285 (43%), Gaps = 27/285 (9%) Query: 8 KQLEKLGNGTYATVYKGLNKTTGVY---VALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 K E +G G + V +G K G VA+K +K E + E S+M + +H N Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPN 78 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 I+RL V+ + ++ EFM+N +DS N + + LV + G+ + Sbjct: 79 IIRLEGVVTNSMPVMILTEFMENGA---LDSFLRLNDGQFTVIQLVG-MLRGIASGMRYL 134 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS-----SEVVTLWYRAPDV 179 E +HRDL +N+L+N K+ DFGL+R + + + + + AP+ Sbjct: 135 AEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEA 194 Query: 180 LMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 + R ++++ D WS G ++ E+++ G+ + ++++ + I P P+ Sbjct: 195 I-AFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPT--- 250 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPD 283 ++ Q ++ + P + +D +++ NP Sbjct: 251 ------SLHQLMLDCWQKDRNARPRFPQVVSALD---KMIR-NPA 285 >2I0E-A nrPDB Length = 353 Score = 214 bits (546), Expect = 3e-56, Method: Composition-based stats. Identities = 56/241 (23%), Positives = 107/241 (44%), Gaps = 11/241 (4%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKE-LK 61 + F L LG G++ V K T A+K +K D ++ + E ++ K Sbjct: 20 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 79 Query: 62 HENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 + +L+ T ++L V E++ DL ++ P ++ ++ G Sbjct: 80 PPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP------HAVFYAAEIAIG 133 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 L F I++RDLK N++++ G +K+ DFG+ + T + T Y AP+++ Sbjct: 134 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 193 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 + Y S+D W+ G +L EM+ G+ F G +++E + I + +S+ + Sbjct: 194 -AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 252 Query: 241 K 241 K Sbjct: 253 K 253 >4AW2-A nrPDB Length = 437 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 59/305 (19%), Positives = 108/305 (35%), Gaps = 46/305 (15%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKL--DSEEGTPSTAIREISLMKELKH 62 F+ L+ +G G + V K A+K + + + E ++ Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDS 133 Query: 63 ENIVRLYDVIHTENKLTLVFEF-MDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 + I L+ +N L LV ++ + DL + L + +++ +++ + Sbjct: 134 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKF-----EDRLPEEMARFYLAEMVIAI 188 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSS-EVVTLWYRAPDVL 180 H+ +HRD+KP N+L++ G ++L DFG SS V T Y +P++L Sbjct: 189 DSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEIL 248 Query: 181 M----GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 G Y D WS G + EM+ G+ F + E I + Sbjct: 249 QAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN------------- 295 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL---SAKQALH 293 + P + N D + L + + RL + Sbjct: 296 ----------------HKERFQFPTQVTDVSENAKDLIRR-LICSREHRLGQNGIEDFKK 338 Query: 294 HPWFA 298 HP+F+ Sbjct: 339 HPFFS 343 >1LUF-A nrPDB Length = 343 Score = 214 bits (545), Expect = 4e-56, Method: Composition-based stats. Identities = 60/259 (23%), Positives = 109/259 (42%), Gaps = 32/259 (12%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGV-------YVALKEVKLDSEEGTPSTAIREISLM 57 + + + +G G + V++ G+ VA+K +K ++ + RE +LM Sbjct: 47 NNIEYVRDIGEGAFGRVFQAR--APGLLPYEPFTMVAVKMLKEEASADMQADFQREAALM 104 Query: 58 KELKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDS------------------RTV 98 E + NIV+L V + L+FE+M DL +++ S R Sbjct: 105 AEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVS 164 Query: 99 GNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF 158 P L Q+ G+A+ E K +HRDL +N L+ + +K+ DFGL+R Sbjct: 165 SPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNI 224 Query: 159 GIPVNTFSS--EVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDE 215 + + + + + P+ + +R Y+T D+W+ G +L E+ + G + G E Sbjct: 225 YSADYYKADGNDAIPIRWMPPESIFYNR-YTTESDVWAYGVVLWEIFSYGLQPYYGMAHE 283 Query: 216 EQLKLIFDIMGTPNESLWP 234 E + + D P Sbjct: 284 EVIYYVRDGNILACPENCP 302 >5EG3-A nrPDB Length = 334 Score = 214 bits (545), Expect = 4e-56, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 124/296 (41%), Gaps = 29/296 (9%) Query: 5 SQFKQLEKLGNGTYATVYK----GLNKTTGVY---VALKEVKLDSEEGTPSTAIREISLM 57 + + LG G + V G++K VA+K +K D+ E S + E+ +M Sbjct: 35 DKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 94 Query: 58 KEL-KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGN----------TPRGL 105 K + KH+NI+ L + L ++ + +L++Y+ +R + Sbjct: 95 KMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQM 154 Query: 106 ELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPV--N 163 + +QL +G+ + K +HRDL +N+L+ + +K+ DFGLAR Sbjct: 155 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFK 214 Query: 164 TFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI- 221 ++ + + + AP+ L R Y+ D+WS G ++ E+ T G +PG EE KL+ Sbjct: 215 ETTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 273 Query: 222 ----FDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDF 273 D L+ + P+ Q+ + L + L + +D Sbjct: 274 EGHRMDKPANCTNELYMMMRDCWHAVPS-QRPTFKQLVEDLDRILTLTTNEEYLDL 328 >6EII-A nrPDB Length = 352 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 82/304 (26%), Positives = 158/304 (51%), Gaps = 21/304 (6%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 + ++ + KLG G Y+ V++ +N T V + REI +++ L+ Sbjct: 57 GNQDDYQLVRKLGRGKYSEVFEAINITNNEK----VVVKILKPVKKKKIKREIKILENLR 112 Query: 62 H-ENIVRLYDVIHTENKLT--LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 NI+ L D++ T LVFE ++N K + + L ++++ +++L Sbjct: 113 GGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL--------YQTLTDYDIRFYMYEIL 164 Query: 119 QGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + L +CH I+HRD+KP N++I+ + +L+L D+GLA F P ++ V + +++ P Sbjct: 165 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGP 223 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 ++L+ + Y S+D+WS GC+LA MI K P F G ++ +QL I ++GT + + Sbjct: 224 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDK 283 Query: 237 TKL---PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 + P++N + + + + + + + +DFL LL+ + RL+A++A+ Sbjct: 284 YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAME 343 Query: 294 HPWF 297 HP+F Sbjct: 344 HPYF 347 >5XVU-A nrPDB Length = 332 Score = 213 bits (544), Expect = 5e-56, Method: Composition-based stats. Identities = 79/306 (25%), Positives = 156/306 (50%), Gaps = 21/306 (6%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 + ++++ ++K+G G Y+ V+ G + A + REI +++ L Sbjct: 28 NKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA----IKVLKPVKKKKIKREIKILQNLN 83 Query: 62 H-ENIVRLYDVIHTE--NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 NI++L D++ +L+FE+++N +D +T+ ++Y+ +Q+L Sbjct: 84 GGPNIIKLLDIVKDPVTKTPSLIFEYINN-----IDFKTLYPK---FTDKDIRYYIYQIL 135 Query: 119 QGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 + L +CH I+HRD+KP N++I+ + Q++L +GLA F P ++ V + +Y+ P Sbjct: 136 KALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLA-EFYHPGQEYNVRVASRYYKGP 194 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLW--- 233 ++L+ + Y S+DIWS GC+LA MI K P F G ++ +QL I ++GT + + Sbjct: 195 ELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKK 254 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 ++ P Y + + + L + ++D + +L + R++ K+A+ Sbjct: 255 YNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAME 314 Query: 294 HPWFAE 299 HP+F E Sbjct: 315 HPYFRE 320 >3C51-A nrPDB Length = 543 Score = 213 bits (544), Expect = 5e-56, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 115/301 (38%), Gaps = 39/301 (12%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP--STAIREISLMKELKHEN 64 F LG G + V+ K TG A K++ + A+ E ++ ++ Sbjct: 187 FLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRF 246 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 IV L T+ L LV M+ +Y + P G + ++ Q++ GL Sbjct: 247 IVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNP-GFQEPRAIFYTAQIVSGLEHL 305 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 H+ I++RDLKP+N+L++ G +++ D GLA T + AP++L+G Sbjct: 306 HQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEE 365 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 Y S+D ++ G L EMI + F ++ Sbjct: 366 -YDFSVDYFALGVTLYEMIAARGPFRARGEK----------------------------V 396 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALHHPWFAE 299 ++ R L Q + + DF LLQ +P+ RL S HP F + Sbjct: 397 ENKELKQRVLEQAVT--YPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRD 454 Query: 300 Y 300 Sbjct: 455 I 455 >5UNP-A nrPDB Length = 369 Score = 213 bits (544), Expect = 5e-56, Method: Composition-based stats. Identities = 80/333 (24%), Positives = 146/333 (43%), Gaps = 50/333 (15%) Query: 4 SSQFKQLEKLGNGTYATVYKGL-NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 +++ + LG GT+ V + + ++ G VALK +K + E A EI++++++ Sbjct: 33 QERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK--NVEKYKEAARLEINVLEKINE 90 Query: 63 EN------IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 ++ V+++D + + FE + ++ P ++ V++ +Q Sbjct: 91 KDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYP----IHQVRHMAFQ 146 Query: 117 LLQGLAFCHENKILHRDLKPQNLL-INKRGQ------------------LKLGDFGLARA 157 L Q + F H+NK+ H DLKP+N+L +N + +++ DFG A Sbjct: 147 LCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA-- 204 Query: 158 FGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQ 217 S+ V T YRAP+V++ +S D+WS GCI+ E G LF ++ E Sbjct: 205 -TFDHEHHSTIVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREH 262 Query: 218 LKLIFDIMGTPNESLWPSVTKLPKYNPN------------IQQRPPRDLRQVLQPHTKEP 265 L ++ I+G + K + + + LR+ L +E Sbjct: 263 LAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEE- 321 Query: 266 LDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 L D + +L+ P RL+ +AL HP+FA Sbjct: 322 -HHQLFDLIESMLEYEPAKRLTLGEALQHPFFA 353 >3FXW-A nrPDB Length = 336 Score = 213 bits (543), Expect = 8e-56, Method: Composition-based stats. Identities = 70/305 (22%), Positives = 116/305 (38%), Gaps = 47/305 (15%) Query: 4 SSQFKQLE-KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 + ++ + LG G V + ++ TG ALK + A +E+ + Sbjct: 27 TDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL------YDSPKARQEVDHHWQASG 80 Query: 63 -ENIVRLYDVIHTENK----LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 +IV + DV + L ++ E M+ + SR + + Sbjct: 81 GPHIVCILDVYENMHHGKRCLLIIMECMEGG---ELFSRIQERGDQAFTEREAAEIMRDI 137 Query: 118 LQGLAFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 + F H + I HRD+KP+NLL K LKL DFG A+ N + T +Y Sbjct: 138 GTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKE--TTQNALQTPCYTPYY 195 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 AP+VL G Y S D+WS G I+ ++ G P F + Sbjct: 196 VAPEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAI----------------- 237 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 +P +++R P E + + + LL+ +P RL+ Q ++H Sbjct: 238 --------SPGMKRRIRLGQYGFPNPEWSE-VSEDAKQLIRLLLKTDPTERLTITQFMNH 288 Query: 295 PWFAE 299 PW + Sbjct: 289 PWINQ 293 >2WTK-C nrPDB Length = 305 Score = 213 bits (543), Expect = 8e-56, Method: Composition-based stats. Identities = 74/308 (24%), Positives = 130/308 (42%), Gaps = 46/308 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPS---TAIREISLMKELK 61 ++ + LG G+Y V + L+ T A+K +K P+ +EI L++ L+ Sbjct: 5 GKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLR 64 Query: 62 HENIVRLYDVI--HTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H+N+++L DV+ + K+ +V E+ +++ +DS + + + QL+ Sbjct: 65 HKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV----PEKRFPVCQAHGYFCQLID 120 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFG--IPVNTFSSEVVTLWYRAP 177 GL + H I+H+D+KP NLL+ G LK+ G+A A +T + + ++ P Sbjct: 121 GLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPP 180 Query: 178 DVLMGSRTYS-TSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 ++ G T+S +DIWS G L + TG F G N + + I P + Sbjct: 181 EIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPL 240 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 + D L G+L+ P R S +Q H W Sbjct: 241 S----------------------------------DLLKGMLEYEPAKRFSIRQIRQHSW 266 Query: 297 FAEYYHHA 304 F + + A Sbjct: 267 FRKKHPPA 274 >4FR4-A nrPDB Length = 384 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 58/306 (18%), Positives = 112/306 (36%), Gaps = 44/306 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKH 62 F+ L +G G++ V T A+K + E +E+ +M+ L+H Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 74 Query: 63 ENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +V L+ E + +V + + DL+ ++ + VK F +L+ L Sbjct: 75 PFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV------HFKEETVKLFICELVMAL 128 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 + +I+HRD+KP N+L+++ G + + DF +A ++ T Y AP++ Sbjct: 129 DYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRE-TQITTMAGTKPYMAPEMFS 187 Query: 182 GSR--TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 + YS ++D WS G E++ G+ + Sbjct: 188 SRKGAGYSFAVDWWSLGVTAYELLRGRRPYH----------------------------- 218 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS-AKQALHHPWFA 298 + + + ++ L LL+ NPD R S + P+ Sbjct: 219 --IRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMN 276 Query: 299 EYYHHA 304 + A Sbjct: 277 DINWDA 282 >1TKI-A nrPDB Length = 321 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 65/303 (21%), Positives = 125/303 (41%), Gaps = 40/303 (13%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 ++ E LG G + V++ + ++ K VK+ + +EIS++ +H N Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVL--VKKEISILNIARHRN 62 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 I+ L++ + +L ++FEF+ + + L + + Q+ + L F Sbjct: 63 ILHLHESFESMEELVMIFEFISG----LDIFERINTSAFELNEREIVSYVHQVCEALQFL 118 Query: 125 HENKILHRDLKPQNLLINKR--GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 H + I H D++P+N++ R +K+ +FG AR P + F Y AP+V Sbjct: 119 HSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLK-PGDNFRLLFTAPEYYAPEVHQH 177 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 ST+ D+WS G ++ +++G F +++ ++ I + T +E + + Sbjct: 178 D-VVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEI------ 230 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYH 302 MDF+ LL R++A +AL HPW + Sbjct: 231 ------------------------SIEAMDFVDRLLVKERKSRMTASEALQHPWLKQKIE 266 Query: 303 HAS 305 S Sbjct: 267 RVS 269 >3A4O-X nrPDB Length = 286 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 63/258 (24%), Positives = 118/258 (45%), Gaps = 14/258 (5%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 K +++LG G + V+ G + VA+K +K + + + E +LMK L+H+ +V Sbjct: 15 IKLVKRLGAGQFGEVWMGYYNNS-TKVAVKTLKPGTM--SVQAFLEEANLMKTLQHDKLV 71 Query: 67 RLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 RLY V+ E + ++ E+M L ++ S + + L + F Q+ +G+A+ Sbjct: 72 RLYAVVTREEPIYIITEYMAKGSLLDFLKS----DEGGKVLLPKLIDFSAQIAEGMAYIE 127 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWYRAPDVLMGSR 184 +HRDL+ N+L+++ K+ DFGLAR + + AP+ + Sbjct: 128 RKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAI-NFG 186 Query: 185 TYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPS---VTKLP 240 ++ D+WS G +L E++T GK +PG + + + + P P Sbjct: 187 CFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKM 246 Query: 241 KYNPNIQQRPPRDLRQVL 258 + ++RP D Q + Sbjct: 247 CWKEKAEERPTFDYLQSV 264 >3KUL-B nrPDB Length = 325 Score = 211 bits (538), Expect = 2e-55, Method: Composition-based stats. Identities = 55/259 (21%), Positives = 111/259 (42%), Gaps = 17/259 (6%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVY---VALKEVKLDSEEGTPSTAIREISLMKEL 60 +S+ + +G+G V G + G VA+K +K E + E S+M + Sbjct: 48 ASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQF 107 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H NI+RL V+ +V E+M+ L ++ + + + + Sbjct: 108 DHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQ-----FTIMQLVGMLRGVGA 162 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN---TFSSEVVTLWYRA 176 G+ + + +HRDL +N+L++ K+ DFGL+R + T + + + + A Sbjct: 163 GMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTA 222 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAE-MITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 P+ + RT+S++ D+WS G ++ E + G+ + + + + + + P P Sbjct: 223 PEAI-AFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPH 281 Query: 236 VTK---LPKYNPNIQQRPP 251 L ++ + QRP Sbjct: 282 ALHQLMLDCWHKDRAQRPR 300 >2OGV-A nrPDB Length = 317 Score = 211 bits (537), Expect = 3e-55, Method: Composition-based stats. Identities = 64/246 (26%), Positives = 110/246 (44%), Gaps = 16/246 (6%) Query: 5 SQFKQLEKLGNGTYATVYK----GLNKTTGV-YVALKEVKLDSEEGTPSTAIREISLMKE 59 + + + LG G + V + GL K V VA+K +K + + E+ +M Sbjct: 38 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSH 97 Query: 60 L-KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGN----TPRGLELNLVKYF 113 L +HENIV L + ++ E+ DL ++ + + R LEL + +F Sbjct: 98 LGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHF 157 Query: 114 QWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVT 171 Q+ QG+AF +HRD+ +N+L+ K+GDFGLAR N + + Sbjct: 158 SSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLP 217 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGT-NDEEQLKLIFDIMGTPN 229 + + AP+ + Y+ D+WS G +L E+ + G +PG + + KL+ D Sbjct: 218 VKWMAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQ 276 Query: 230 ESLWPS 235 + P Sbjct: 277 PAFAPK 282 >2WTK-B nrPDB Length = 373 Score = 210 bits (536), Expect = 5e-55, Method: Composition-based stats. Identities = 76/337 (22%), Positives = 125/337 (37%), Gaps = 50/337 (14%) Query: 4 SSQFKQLEKLGNGTY---ATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLMKE 59 ++ L +G G + TV K TG YV ++ + L++ T ++ E+ + K Sbjct: 8 GGCYELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKL 66 Query: 60 LKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 H NIV +N+L +V FM K + + G+ + Y +L Sbjct: 67 FNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLI----CTHFMDGMNELAIAYILQGVL 122 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-------- 170 + L + H +HR +K ++LI+ G++ L GL + + VV Sbjct: 123 KALDYIHHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSV 180 Query: 171 -TLWYRAPDVLMGS-RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQL--------KL 220 L + +P+VL + + Y DI+S G E+ G F + L Sbjct: 181 KVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPC 240 Query: 221 IFDIMGTPNESLWPSVTKLPKY------------NPNIQQRPPRDLRQVLQPHTKEPLDG 268 + D P E L S ++ P+ P + PH Sbjct: 241 LLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPH------- 293 Query: 269 NLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 F+ LQ NPD R SA L+H +F + AS Sbjct: 294 -FHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRAS 329 >2XNP-A nrPDB Length = 279 Score = 210 bits (534), Expect = 8e-55, Method: Composition-based stats. Identities = 81/307 (26%), Positives = 126/307 (41%), Gaps = 45/307 (14%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKEL 60 S + ++ L +G G+Y K K+ G + KE+ S E + E++L++EL Sbjct: 3 SRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLREL 62 Query: 61 KHENIVRLYDVIHTENK--LTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 KH NIVR YD I L +V E+ + DL + T + L+ V QL Sbjct: 63 KHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGT--KERQYLDEEFVLRVMTQL 120 Query: 118 LQGLAFCHE-----NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTL 172 L CH + +LHRDLKP N+ ++ + +KLGDFGLAR + + V T Sbjct: 121 TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP 180 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESL 232 +Y +P+ M +Y+ DIWS GC+L E+ P F + +E I + Sbjct: 181 YYMSPEQ-MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYR 239 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 + L + + +L L R S ++ L Sbjct: 240 Y---------------------------------SDELNEIITRMLNLKDYHRPSVEEIL 266 Query: 293 HHPWFAE 299 +P E Sbjct: 267 ENPLILE 273 >4OLI-A nrPDB Length = 645 Score = 210 bits (534), Expect = 8e-55, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 121/295 (41%), Gaps = 36/295 (12%) Query: 7 FKQLEKLGNGTYATV----YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 K++ LG G + V Y N TG VA+K +K D S +EI +++ L H Sbjct: 355 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYH 414 Query: 63 ENIVRLYDVIHTENK--LTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 E+I++ + + L LV E++ L+ Y+ ++G L + F Q+ + Sbjct: 415 EHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIG-------LAQLLLFAQQICE 467 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV---VTLWYRA 176 G+A+ H +HR+L +N+L++ +K+GDFGLA+A + +++ A Sbjct: 468 GMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYA 527 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P+ L + Y + D+WS G L E++T + + L+LI G + Sbjct: 528 PECLKEYKFY-YASDVWSFGVTLYELLTHCDSSQ-SPPTKFLELIGIAQGQMTVLRLTEL 585 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 + + P + P + + + R + + Sbjct: 586 LERGERLPRPDKCPC-----------------EVYHLMKNCWETEASFRPTFENL 623 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 66/333 (19%), Positives = 118/333 (35%), Gaps = 48/333 (14%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTG------------------------VYVALKEV 38 + QL LG GT VY+G + G + V LK + Sbjct: 43 DQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVL 102 Query: 39 KLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTV 98 S SLM ++ H ++ ++ V + +V E++++ R Sbjct: 103 DP-SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRER 161 Query: 99 GNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQ-------LKLGD 151 G+ P ++ QL L++ ++H ++ +N+L+ + G +KL D Sbjct: 162 GHVPMAWKM----VVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSD 217 Query: 152 FGLARAFGIPVNTFSSEVVTLWYRAPDVL-MGSRTYSTSIDIWSCGCILAEMIT-GKPLF 209 G G+ + V + + AP+ L G+ + ST++D W G L E+ G+ Sbjct: 218 PG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPL 273 Query: 210 PGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGN 269 + E+ P S P + L + R +L+ T+ N Sbjct: 274 QSRSPSEKEHFYQRQHRLPEPS-CPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPH-N 331 Query: 270 LMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYH 302 L D L +NPD S H + + Sbjct: 332 LADV----LTVNPDSPASDPTVFHKRYLKKIRD 360 >5KMM-A nrPDB Length = 329 Score = 210 bits (534), Expect = 8e-55, Method: Composition-based stats. Identities = 64/298 (21%), Positives = 112/298 (37%), Gaps = 53/298 (17%) Query: 12 KLGNGTYATVYKGLNKT-----TGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 +LG G + V+ + VA+K +K ++ E RE L+ L+H++IV Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQDFQREAELLTMLQHQHIV 100 Query: 67 RLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNT---------PRGLELNLVKYFQWQ 116 R + V L +VFE+M DL +++ S P L L + Q Sbjct: 101 RFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQ 160 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSS--EVVTLWY 174 + G+ + +HRDL +N L+ + +K+GDFG++R ++ + + Sbjct: 161 VAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRW 220 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 P+ ++ R ++T D+WS G +L E+ T GK + ++ E + I Sbjct: 221 MPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC 279 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 P + + G Q P R S K Sbjct: 280 P---------------------------------PEVYAIMRGCWQREPQQRHSIKDV 304 >6CCF-A nrPDB Length = 290 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 74/326 (22%), Positives = 123/326 (37%), Gaps = 71/326 (21%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGT------------------ 46 +Q+K ++G G Y V N++ + A+K + Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 47 -------PSTAIREISLMKELKHENIVRLYDVIHT--ENKLTLVFEFMDNDLKKYMDSRT 97 +EI+++K+L H N+V+L +V+ E+ L LVF + Sbjct: 65 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVF--------DLLRKGP 116 Query: 98 VGNTP--RGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLA 155 V P + + + ++ GL + H KI+HRD+KP NLL+ G +K+ DFG++ Sbjct: 117 VMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVS 176 Query: 156 RAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY--STSIDIWSCGCILAEMITGKPLFPGTN 213 F SS T + AP+ + S ++D+W+ G L + GK F Sbjct: 177 NQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF---I 233 Query: 214 DEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDF 273 D+ L L I P V+ P E + L D Sbjct: 234 DDFILALHRKIKNEP----------------------------VVFPEEPE-ISEELKDL 264 Query: 274 LHGLLQLNPDMRLSAKQALHHPWFAE 299 + +L NP+ R+ HPW + Sbjct: 265 ILKMLDKNPETRIGVPDIKLHPWVTK 290 >2VD5-A nrPDB Length = 412 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 110/306 (35%), Gaps = 48/306 (15%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKL--DSEEGTPSTAIREISLMKELKH 62 F+ L+ +G G ++ V K TG A+K + + G S E ++ Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 63 ENIVRLYDVIHTENKLTLVFEF-MDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 I +L+ EN L LV E+ + DL + + + +++ +++ + Sbjct: 121 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFG-----ERIPAEMARFYLAEIVMAI 175 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS-SEVVTLWYRAPDVL 180 H +HRD+KP N+L+++ G ++L DFG S V T Y +P++L Sbjct: 176 DSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEIL 235 Query: 181 MG------SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 + +Y D W+ G EM G+ F + E I Sbjct: 236 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK--------- 286 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL---SAKQA 291 + P E + DF+ LL P+ RL A Sbjct: 287 --------------------EHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDF 325 Query: 292 LHHPWF 297 HP+F Sbjct: 326 RTHPFF 331 >5HI2-A nrPDB Length = 283 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 64/295 (21%), Positives = 127/295 (43%), Gaps = 46/295 (15%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 Q +++G+G++ TVYKG VA+K + E+ ++++ +H Sbjct: 19 DGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML----TPQQLQAFKNEVGVLRKTRHV 71 Query: 64 NIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 NI+ T+ +L +V ++ + L ++ + + E+ + Q +G+ Sbjct: 72 NILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHA-----SETKFEMKKLIDIARQTARGMD 125 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLA--RAFGIPVNTFSSEVVTLWYRAPDVL 180 + H I+HRDLK N+ +++ +K+GDFGLA ++ + F ++ + AP+V+ Sbjct: 126 YLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 185 Query: 181 --MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 S YS D+++ G +L E++TG+ + N+ +Q+ I SL P ++K Sbjct: 186 RMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQI-----IEMVGRGSLSPDLSK 240 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 + P +R + L+ D R S + L Sbjct: 241 VRSNCPKRMKR-----------------------LMAECLKKKRDERPSFPRILA 272 >4H1J-A nrPDB Length = 293 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 115/250 (46%), Gaps = 18/250 (7%) Query: 11 EKLGNGTYATVYKGL---NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVR 67 LG G + VY+G+ +K + VA+K K D + E +MK L H +IV+ Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVK 89 Query: 68 LYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 L +I E ++ E +L Y++ L++ + + Q+ + +A+ Sbjct: 90 LIGIIEEE-PTWIIMELYPYGELGHYLERNK-----NSLKVLTLVLYSLQICKAMAYLES 143 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSS-EVVTLWYRAPDVLMGSRT 185 +HRD+ +N+L+ +KLGDFGL+R +S + + + +P+ + R Sbjct: 144 INCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESI-NFRR 202 Query: 186 YSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV-----TKL 239 ++T+ D+W + E+++ GK F +++ + ++ P L P V T+ Sbjct: 203 FTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRC 262 Query: 240 PKYNPNIQQR 249 Y+P+ + R Sbjct: 263 WDYDPSDRPR 272 >3CJF-A nrPDB Length = 309 Score = 208 bits (530), Expect = 2e-54, Method: Composition-based stats. Identities = 63/307 (20%), Positives = 120/307 (39%), Gaps = 50/307 (16%) Query: 5 SQFKQLEKLGNGTYATVYK----GLNKT-TGVYVALKEVKLDSEEGTPSTAIREISLMKE 59 + + LG G + V + G++KT T VA+K +K + + E+ ++ Sbjct: 27 DRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIH 86 Query: 60 LKHE-NIVRLYDVIHTEN-KLTLVFEFMD-NDLKKYMDSRTVGNTP------RGLELNLV 110 + H N+V L L ++ EF +L Y+ S+ P L L + Sbjct: 87 IGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHL 146 Query: 111 KYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS--SE 168 + +Q+ +G+ F K +HRDL +N+L++++ +K+ DFGLAR + Sbjct: 147 ICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDA 206 Query: 169 VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGT 227 + L + AP+ + R Y+ D+WS G +L E+ + G +PG +E+ Sbjct: 207 RLPLKWMAPETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEF--------- 256 Query: 228 PNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 R L++ + + + + P R + Sbjct: 257 -----------------------CRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPT 293 Query: 288 AKQALHH 294 + + H Sbjct: 294 FSELVEH 300 >1FVR-A nrPDB Length = 327 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 59/303 (19%), Positives = 112/303 (36%), Gaps = 50/303 (16%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYV--ALKEVKLDSEEGTPSTAIREISLMKEL-K 61 + K + +G G + V K K G+ + A+K +K + + E+ ++ +L Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGH 84 Query: 62 HENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLEL----------NLV 110 H NI+ L L L E+ +L ++ V T + + Sbjct: 85 HPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQL 144 Query: 111 KYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV 170 +F + +G+ + + + +HRDL +N+L+ + K+ DFGL+R + V + Sbjct: 145 LHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRL- 203 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPN 229 + + A + L Y+T+ D+WS G +L E+++ G + G E + Sbjct: 204 PVRWMAIESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEK--------- 253 Query: 230 ESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 L Q + D + D + + P R S Sbjct: 254 ------------------------LPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFA 289 Query: 290 QAL 292 Q L Sbjct: 290 QIL 292 >4GS6-A nrPDB Length = 315 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 75/313 (23%), Positives = 124/313 (39%), Gaps = 55/313 (17%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 M + + E +G G + V K K VA+K+++ +SE I E+ + + Sbjct: 5 MIDYKEIEVEEVVGRGAFGVVCKA--KWRAKDVAIKQIESESE---RKAFIVELRQLSRV 59 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H NIV+LY N + LV E+ + L + + Q Q Sbjct: 60 NHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYY---TAAHAMSWCLQCSQ 114 Query: 120 GLAFCHENK---ILHRDLKPQNLLINKRGQL-KLGDFGLARAFGIPVNTFSSEVVTLWYR 175 G+A+ H + ++HRDLKP NLL+ G + K+ DFG A ++ + + Sbjct: 115 GVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ---THMTNNKGSAAWM 171 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 AP+V GS YS D++S G IL E+IT + F D +G P + Sbjct: 172 APEVFEGS-NYSEKCDVFSWGIILWEVITRRKPF-------------DEIGGPAFRIM-- 215 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ---AL 292 + + RPP L + +P++ + +P R S ++ + Sbjct: 216 ------WAVHNGTRPP------LIKNLPKPIES----LMTRCWSKDPSQRPSMEEIVKIM 259 Query: 293 HHPWFAEYYHHAS 305 H Y+ A Sbjct: 260 TH--LMRYFPGAD 270 >4PWN-A nrPDB Length = 274 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 84/309 (27%), Positives = 135/309 (43%), Gaps = 50/309 (16%) Query: 1 MSSSSQFKQLE-KLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMK 58 MS+ +F + + ++G G++ TVYKGL+ T V VA E++ + E ++K Sbjct: 5 MSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLK 64 Query: 59 ELKHENIVRLYDVIHT----ENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYF 113 L+H NIVR YD + + + LV E M LK Y+ V +++ +++ + Sbjct: 65 GLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKV------MKIKVLRSW 118 Query: 114 QWQLLQGLAFCHEN--KILHRDLKPQNLLINKR-GQLKLGDFGLARAFGIPVNTFSSEVV 170 Q+L+GL F H I+HRDLK N+ I G +K+GD GLA + S + Sbjct: 119 CRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA-TLEKRASFAKSVIG 177 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNE 230 T + AP+ M Y S+D+++ G + EM T + + + Q+ Sbjct: 178 TPEFMAPE--MYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQI------------ 223 Query: 231 SLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 Y P +V P KE + G ++ N D R S K Sbjct: 224 -----------YRRVTSGVKPASFDKVAIPEVKE--------IIEGCIRQNKDERYSIKD 264 Query: 291 ALHHPWFAE 299 L+H +F E Sbjct: 265 LLNHAFFQE 273 >4UY9-A nrPDB Length = 323 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 73/265 (27%), Positives = 115/265 (43%), Gaps = 31/265 (11%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA---IREISLMKELKH 62 + E +G G + VY+ G VA+K + D +E T +E L LKH Sbjct: 10 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 67 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NI+ L V E L LV EF L + + + + +++ + Q+ +G+ Sbjct: 68 PNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR-------IPPDILVNWAVQIARGM 120 Query: 122 AFCHENK---ILHRDLKPQNLLINK--------RGQLKLGDFGLARAFGIPVNTFSSEVV 170 + H+ I+HRDLK N+LI + LK+ DFGLAR + T S Sbjct: 121 NYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH--RTTKMSAAG 178 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQ-LKLIFDIMGTPN 229 T + AP+V+ S +S D+WS G +L E++TG+ F G + + + + P Sbjct: 179 TYAWMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPI 237 Query: 230 ESLWPSVTK---LPKYNPNIQQRPP 251 S P +NP+ RP Sbjct: 238 PSTCPEPFAKLMEDCWNPDPHSRPS 262 >6GVJ-A nrPDB Length = 429 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 74/312 (23%), Positives = 130/312 (41%), Gaps = 54/312 (17%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLMKELK--HE 63 + L+++G+G + V++ LN A+K V L+ + + R EI+ + +L+ + Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 I+RLYD T+ + +V E + DL ++ + + ++ K + +L+ + Sbjct: 205 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKK------KSIDPWERKSYWKNMLEAVHT 258 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVTLWYRAPDVLM 181 H++ I+H DLKP N LI G LKL DFG+A + S+V T+ Y P+ + Sbjct: 259 IHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 317 Query: 182 G----------SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 S D+WS GCIL M GK F ++ + I + + + Sbjct: 318 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-----QQIINQISKLHAIIDPN 372 Query: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 +P+ +L D L L+ +P R+S + Sbjct: 373 HEIEFPDIPE--------------------------KDLQDVLKCCLKRDPKQRISIPEL 406 Query: 292 LHHPWFAEYYHH 303 L HP+ H Sbjct: 407 LAHPYVQIQTHP 418 >3I81-A nrPDB Length = 315 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 64/302 (21%), Positives = 118/302 (39%), Gaps = 47/302 (15%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNK-----TTGVYVALKEVKLDSEEGTPSTAIREISLM 57 + + +LG G++ VY+G+ K VA+K V + + E S+M Sbjct: 16 AREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVM 75 Query: 58 KELKHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGL----ELNLVKY 112 KE ++VRL V+ ++ E M DLK Y+ S + L+ + Sbjct: 76 KEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQ 135 Query: 113 FQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-- 170 ++ G+A+ + NK +HRDL +N ++ + +K+GDFG+ R Sbjct: 136 MAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLL 195 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPN 229 + + +P+ L ++T D+WS G +L E+ T + + G ++E+ L+ + + Sbjct: 196 PVRWMSPESLKDG-VFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDK 254 Query: 230 ESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 P + L + + Q NP MR S Sbjct: 255 PDNCPDM---------------------------------LFELMRMCWQYNPKMRPSFL 281 Query: 290 QA 291 + Sbjct: 282 EI 283 >6DBM-A nrPDB Length = 318 Score = 207 bits (527), Expect = 5e-54, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 123/295 (41%), Gaps = 36/295 (12%) Query: 7 FKQLEKLGNGTYATV----YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 K++ LG G + V Y N TG VA+K +K D+ S +EI +++ L H Sbjct: 33 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYH 92 Query: 63 ENIVRLYDVIHTEN--KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 E+I++ L LV E++ L+ Y+ ++G L + F Q+ + Sbjct: 93 EHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIG-------LAQLLLFAQQICE 145 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV---VTLWYRA 176 G+A+ H +HRDL +N+L++ +K+GDFGLA+A + +++ A Sbjct: 146 GMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYA 205 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P+ L + Y + D+WS G L E++T + + +++G + +V Sbjct: 206 PECLKEYKFY-YASDVWSFGVTLYELLT-----HCDSSQSPPTKFLELIGIAQGQM--TV 257 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 +L + ++ P D + + + R + + Sbjct: 258 LRLTELLERGERLPRPD-----------KCPAEVYHLMKNCWETEASFRPTFENL 301 >4R7H-A nrPDB Length = 343 Score = 207 bits (527), Expect = 5e-54, Method: Composition-based stats. Identities = 65/259 (25%), Positives = 110/259 (42%), Gaps = 29/259 (11%) Query: 5 SQFKQLEKLGNGTYATVYK----GLNKTTGV-YVALKEVKLDSEEGTPSTAIREISLMKE 59 + + + LG G + V + GL K V VA+K +K + + E+ +M Sbjct: 50 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSH 109 Query: 60 L-KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSR-----------------TVGN 100 L +HENIV L + ++ E+ DL ++ + Sbjct: 110 LGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKE 169 Query: 101 TPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGI 160 R LEL + +F Q+ QG+AF +HRD+ +N+L+ K+GDFGLAR Sbjct: 170 DGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN 229 Query: 161 PVNTF--SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGT-NDEE 216 N + + + + AP+ + S Y+ D+WS G +L E+ + G +PG + + Sbjct: 230 DSNYIVKGNARLPVKWMAPESIFDS-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSK 288 Query: 217 QLKLIFDIMGTPNESLWPS 235 KL+ D + P Sbjct: 289 FYKLVKDGYQMAQPAFAPK 307 >4OTD-A nrPDB Length = 341 Score = 207 bits (527), Expect = 5e-54, Method: Composition-based stats. Identities = 73/304 (24%), Positives = 124/304 (40%), Gaps = 53/304 (17%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKEL-- 60 FK L LG G + V + +G A+K +K + + E ++ + Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 61 -KHENIVRLYDVIHTENKLTLVFEF-MDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 H +V L+ T + V E+ DL ++ S ++ ++ Sbjct: 72 AGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-------DVFSEPRAIFYSACVV 124 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 GL F HE+KI++RDLK NLL++ G +K+ DFGL + + S+ T + AP+ Sbjct: 125 LGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 184 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 VL + +Y+ ++D W G +L EM+ G+ FPG ++EE I + +E +P Sbjct: 185 VLTDT-SYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN-----DEVRYPRF-- 236 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALH 293 L + + LL+ NP+ RL A+ Sbjct: 237 ---------------------------LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKK 269 Query: 294 HPWF 297 P+F Sbjct: 270 QPFF 273 >3RAW-A nrPDB Length = 381 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 76/331 (22%), Positives = 135/331 (40%), Gaps = 46/331 (13%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGV-YVALKEVKLDSEEGTPSTAIREISLMKELKH 62 +++ + LG GT+ V + L+ G VALK ++ + A EI+++K++K Sbjct: 50 QERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIR--NVGKYREAARLEINVLKKIKE 107 Query: 63 EN------IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 ++ V + D + + + FE + + +++ P L V++ +Q Sbjct: 108 KDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYP----LPHVRHMAYQ 163 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINK-------------------RGQLKLGDFGLARA 157 L L F HEN++ H DLKP+N+L +++ DFG A Sbjct: 164 LCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA-- 221 Query: 158 FGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQ 217 ++ V T YR P+V++ ++ D+WS GCIL E G LF + E Sbjct: 222 -TFDHEHHTTIVATRHYRPPEVIL-ELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREH 279 Query: 218 LKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDG--------- 268 L ++ I+G + K + +PL Sbjct: 280 LVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEH 339 Query: 269 -NLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 L D + +L+ +P R++ +AL HP+FA Sbjct: 340 VQLFDLMRRMLEFDPAQRITLAEALLHPFFA 370 >3KRL-A nrPDB Length = 335 Score = 207 bits (526), Expect = 6e-54, Method: Composition-based stats. Identities = 62/252 (24%), Positives = 107/252 (42%), Gaps = 22/252 (8%) Query: 5 SQFKQLEKLGNGTYATVYK----GLNKTTGV-YVALKEVKLDSEEGTPSTAIREISLMKE 59 + + + LG G + V + GL K V VA+K +K + + E+ +M Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSH 105 Query: 60 L-KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTV----------GNTPRGLEL 107 L +HENIV L + ++ E+ DL ++ + N L Sbjct: 106 LGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSS 165 Query: 108 NLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF-- 165 + +F Q+ QG+AF +HRD+ +N+L+ K+GDFGLAR N Sbjct: 166 RDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVK 225 Query: 166 SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGT-NDEEQLKLIFD 223 + + + + AP+ + Y+ D+WS G +L E+ + G +PG + + KL+ D Sbjct: 226 GNARLPVKWMAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKD 284 Query: 224 IMGTPNESLWPS 235 + P Sbjct: 285 GYQMAQPAFAPK 296 >1K9A-A nrPDB Length = 450 Score = 206 bits (525), Expect = 9e-54, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 119/298 (39%), Gaps = 52/298 (17%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 + + K L+ +G G + V G + G VA+K +K D+ + E S+M +L+H Sbjct: 191 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA---QAFLAEASVMTQLRH 245 Query: 63 ENIVRLYDVI-HTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 N+V+L VI + L +V E+M L Y+ SR L + + F + + Sbjct: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS----VLGGDCLLKFSLDVCEA 301 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 + + N +HRDL +N+L+++ K+ DFGL + +T + + + AP+ L Sbjct: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPEAL 358 Query: 181 MGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 + +ST D+WS G +L E+ + G+ +P ++ + + P Sbjct: 359 R-EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP----- 412 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA---LHH 294 + D + L+ R + Q L H Sbjct: 413 ----------------------------PAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 >2HK5-A nrPDB Length = 270 Score = 206 bits (525), Expect = 9e-54, Method: Composition-based stats. Identities = 65/251 (25%), Positives = 119/251 (47%), Gaps = 17/251 (6%) Query: 7 FKQLEKLGNGTYATVYKG-LNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 K +KLG G + V+ NK T VA+K +K S + + E ++MK L+H+ + Sbjct: 17 LKLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSM--SVEAFLAEANVMKTLQHDKL 72 Query: 66 VRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 V+L+ V+ T+ + ++ EFM L ++ S P L + F Q+ +G+AF Sbjct: 73 VKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQP----LPKLIDFSAQIAEGMAFI 127 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWYRAPDVLMGS 183 + +HRDL+ N+L++ K+ DFGLAR + + AP+ + Sbjct: 128 EQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAI-NF 186 Query: 184 RTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK---L 239 +++ D+WS G +L E++T G+ +PG ++ E ++ + P P + Sbjct: 187 GSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMM 246 Query: 240 PKYNPNIQQRP 250 + ++RP Sbjct: 247 RCWKNRPEERP 257 >3QGY-A nrPDB Length = 286 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 62/265 (23%), Positives = 120/265 (45%), Gaps = 17/265 (6%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 S+ ++++G+G + V+ G VA+K +K S + I E +M +L H Sbjct: 25 DPSELTFVQEIGSGQFGLVHLGYWLN-KDKVAIKTIKEGSM--SEDDFIEEAEVMMKLSH 81 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +V+LY V + + LVFEFM++ L Y+ ++ + + +G+ Sbjct: 82 PKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-----FAAETLLGMCLDVCEGM 136 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLAR-AFGIPVNTFSSEVVTLWYRAPDVL 180 A+ E ++HRDL +N L+ + +K+ DFG+ R + + + + +P+V Sbjct: 137 AYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVF 196 Query: 181 MGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNE-----SLWP 234 SR YS+ D+WS G ++ E+ + GK + ++ E ++ I ++ Sbjct: 197 SFSR-YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 255 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQ 259 + K P + R LRQ+ + Sbjct: 256 IMNHCWKERPEDRPAFSRLLRQLAE 280 >6FER-A nrPDB Length = 309 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 60/310 (19%), Positives = 122/310 (39%), Gaps = 52/310 (16%) Query: 7 FKQLEKLGNGTYATVYKG--------LNKT--------TGVYVALKEVKLDSEEGTPSTA 50 EKLG G + V+ +K V VA+K ++ D+ + + Sbjct: 11 LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDF 70 Query: 51 IREISLMKELKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTP----RGL 105 ++EI +M LK NI+ L V T++ L ++ E+M+ DL +++ N+ R + Sbjct: 71 LKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTV 130 Query: 106 ELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF 165 +K+ Q+ G+ + +HRDL +N L+ K +K+ DFG++R Sbjct: 131 SYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYR 190 Query: 166 --SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT--GKPLFPGTNDEEQLKLI 221 V+ + + + + ++ + ++T+ D+W+ G L E T + + +DE+ ++ Sbjct: 191 IQGRAVLPIRWMSWESILLGK-FTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIE-- 247 Query: 222 FDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLN 281 N + Y P P + + + + Sbjct: 248 -------NTGEFFRDQGRQTYLPQPAICPDSVYK-----------------LMLSCWRRD 283 Query: 282 PDMRLSAKQA 291 R S ++ Sbjct: 284 TKNRPSFQEI 293 >3DTC-A nrPDB Length = 271 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 72/265 (27%), Positives = 114/265 (43%), Gaps = 31/265 (11%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA---IREISLMKELKH 62 + E +G G + VY+ G VA+K + D +E T +E L LKH Sbjct: 8 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 65 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NI+ L V E L LV EF L + + + + +++ + Q+ +G+ Sbjct: 66 PNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR-------IPPDILVNWAVQIARGM 118 Query: 122 AFCHENK---ILHRDLKPQNLLINK--------RGQLKLGDFGLARAFGIPVNTFSSEVV 170 + H+ I+HRDLK N+LI + LK+ DFGLAR + T S Sbjct: 119 NYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH--RTTKMSAAG 176 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQ-LKLIFDIMGTPN 229 + AP+V+ S +S D+WS G +L E++TG+ F G + + + + P Sbjct: 177 AYAWMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPI 235 Query: 230 ESLWPSVTK---LPKYNPNIQQRPP 251 S P +NP+ RP Sbjct: 236 PSTCPEPFAKLMEDCWNPDPHSRPS 260 >3BEA-A nrPDB Length = 333 Score = 205 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 61/250 (24%), Positives = 107/250 (42%), Gaps = 20/250 (8%) Query: 5 SQFKQLEKLGNGTYATVYK----GLNKTTGV-YVALKEVKLDSEEGTPSTAIREISLMKE 59 + + + LG G + V + GL K V VA+K +K + + E+ +M Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSH 105 Query: 60 L-KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRG--------LELNL 109 L +HENIV L + ++ E+ DL ++ ++ L Sbjct: 106 LGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRD 165 Query: 110 VKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SS 167 + +F Q+ QG+AF +HRD+ +N+L+ K+GDFGLAR N + Sbjct: 166 LLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGN 225 Query: 168 EVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGT-NDEEQLKLIFDIM 225 + + + AP+ + Y+ D+WS G +L E+ + G +PG + + KL+ D Sbjct: 226 ARLPVKWMAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGY 284 Query: 226 GTPNESLWPS 235 + P Sbjct: 285 QMAQPAFAPK 294 >5AMN-A nrPDB Length = 299 Score = 205 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 58/255 (22%), Positives = 114/255 (44%), Gaps = 19/255 (7%) Query: 9 QLEKLGNGTYATVYKG-----LNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 + LG G + V K + VA+K +K ++ + E +++K++ H Sbjct: 27 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHP 86 Query: 64 NIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTV----GNTPRGLELNLVKYFQWQLL 118 ++++LY + L L+ E+ L+ ++ R L + + F WQ+ Sbjct: 87 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQIS 146 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV--TLWYRA 176 QG+ + E K++HRDL +N+L+ + ++K+ DFGL+R + + + A Sbjct: 147 QGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMA 206 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI-----FDIMGTPNE 230 + L Y+T D+WS G +L E++T G +PG E L+ + +E Sbjct: 207 IESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSE 265 Query: 231 SLWPSVTKLPKYNPN 245 ++ + + K P+ Sbjct: 266 EMYRLMLQCWKQEPD 280 >4UYA-A nrPDB Length = 340 Score = 205 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 70/304 (23%), Positives = 116/304 (38%), Gaps = 59/304 (19%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP---STAIREISLMKELK 61 + + E +G G + VY+ + G VA+K + D E+ + RE L L+ Sbjct: 26 ERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLR 83 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 H NI+ L V + L LV EF + R + +++ + Q+ +G+ Sbjct: 84 HPNIIELRGVCLQQPHLCLVLEFARGG------ALNRALAGRRIPPHVLVNWAVQIARGM 137 Query: 122 AFCHENK---ILHRDLKPQNLLINK--------RGQLKLGDFGLARAFGIPVNTFSSEVV 170 + HE ILHRDLK N+L+ + LK+ DFGLAR + ++ Sbjct: 138 LYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATA--G 195 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQ-LKLIFDIMGTPN 229 + AP+V+ S +S DIWS G +L E++TG+ + G + + + + P Sbjct: 196 AYAWMAPEVIKSS-LFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPI 254 Query: 230 ESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 S P + Q +P +R S Sbjct: 255 PSTCP---------------------------------EPFAKLMKECWQQDPHIRPSFA 281 Query: 290 QALH 293 L Sbjct: 282 LILE 285 >5O2B-A nrPDB Length = 285 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 85/308 (27%), Positives = 133/308 (43%), Gaps = 51/308 (16%) Query: 2 SSSSQFKQLE-KLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKE 59 S S +F + + +LG G + TVYKGL+ T V VA E++ + E ++K Sbjct: 12 SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKG 71 Query: 60 LKHENIVRLYDVIHT----ENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQ 114 L+H NIVR YD + + + LV E M LK Y+ V ++ +++ + Sbjct: 72 LQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKV------MKPKVLRSWC 125 Query: 115 WQLLQGLAFCHEN--KILHRDLKPQNLLINKR-GQLKLGDFGLARAFGIPVNTFSSEVVT 171 Q+L+GL F H I+HRDLK N+ I G +K+GD GLA + S + T Sbjct: 126 RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM--RTSFAKSVIGT 183 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 + AP+ M Y S+D+++ G + EM T + + + Q+ Sbjct: 184 PEFMAPE--MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQI------------- 228 Query: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 Y P +V P KE + G ++ N RLS + Sbjct: 229 ----------YRKVTSGIKPASFNKVTDPEVKE--------IIEGCIRQNKSERLSIRDL 270 Query: 292 LHHPWFAE 299 L+H +FAE Sbjct: 271 LNHAFFAE 278 >5O2C-A nrPDB Length = 380 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 85/308 (27%), Positives = 133/308 (43%), Gaps = 51/308 (16%) Query: 2 SSSSQFKQLE-KLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKE 59 S S +F + + +LG G + TVYKGL+ T V VA E++ + E ++K Sbjct: 21 SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKG 80 Query: 60 LKHENIVRLYDVIHT----ENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQ 114 L+H NIVR YD + + + LV E M LK Y+ V ++ +++ + Sbjct: 81 LQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKV------MKPKVLRSWC 134 Query: 115 WQLLQGLAFCHEN--KILHRDLKPQNLLINKR-GQLKLGDFGLARAFGIPVNTFSSEVVT 171 Q+L+GL F H I+HRDLK N+ I G +K+GD GLA + S + T Sbjct: 135 RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM--RTSFAKSVIGT 192 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 + AP+ M Y S+D+++ G + EM T + + + Q+ Sbjct: 193 PEFMAPE--MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQI------------- 237 Query: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 Y P +V P KE + G ++ N RLS + Sbjct: 238 ----------YRKVTSGIKPASFNKVTDPEVKE--------IIEGCIRQNKSERLSIRDL 279 Query: 292 LHHPWFAE 299 L+H +FAE Sbjct: 280 LNHAFFAE 287 >5VO2-A nrPDB Length = 300 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 107/291 (36%), Gaps = 51/291 (17%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 + L+ +G+G V+ G G VA+K+V+ E I +++LKH N Sbjct: 12 EEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD--------IKHLRKLKHPN 61 Query: 65 IVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 I+ V ++ EF L + + + R + +L+ + + G+ + Sbjct: 62 IITFKGVCTQAPCYCILMEFCAQGQLYEVLRA------GRPVTPSLLVDWSMGIAGGMNY 115 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 H +KI+HRDLK N+LI +K+ DFG ++ S T+ + AP+V+ Sbjct: 116 LHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKM-SFAGTVAWMAPEVIRN- 173 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 S +DIWS G +L E++TG+ + + + + Sbjct: 174 EPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVG--------------------- 212 Query: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 L L P R S +Q L H Sbjct: 213 -----------SNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH 252 >5HIE-A nrPDB Length = 302 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 63/295 (21%), Positives = 122/295 (41%), Gaps = 46/295 (15%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 Q +++G+G++ TVYKG VA+K + E+ ++++ +H Sbjct: 35 DGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML----TPQQLQAFKNEVGVLRKTRHV 87 Query: 64 NIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 NI+ T+ +L +V ++ + L ++ E+ + Q QG+ Sbjct: 88 NILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHI-----IETKFEMIKLIDIARQTAQGMD 141 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLA--RAFGIPVNTFSSEVVTLWYRAPDVL 180 + H I+HRDLK N+ +++ +K+GDFGLA ++ + F ++ + AP+V+ Sbjct: 142 YLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 201 Query: 181 --MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 YS D+++ G +L E++TG+ + N+ +Q+ I L P ++K Sbjct: 202 RMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQI-----IFMVGRGYLSPDLSK 256 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 + P +R + L+ D R Q L Sbjct: 257 VRSNCPKAMKR-----------------------LMAECLKKKRDERPLFPQILA 288 >3BBT-B nrPDB Length = 328 Score = 205 bits (521), Expect = 2e-53, Method: Composition-based stats. Identities = 55/237 (23%), Positives = 108/237 (45%), Gaps = 15/237 (6%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGV----YVALKEVKLDSEEGTPSTAIREISLMKEL 60 ++ K+++ LG+G + TVYKG+ G VA+K + + + E +M + Sbjct: 15 TELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASM 74 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H ++VRL V + + LV + M + L +Y+ + L + Q+ + Sbjct: 75 DHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLL-----LNWCVQIAK 128 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV--TLWYRAP 177 G+ + E +++HRDL +N+L+ +K+ DFGLAR ++++ + + A Sbjct: 129 GMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMAL 188 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 + + R ++ D+WS G + E++T G + G E L+ P + Sbjct: 189 ECIH-YRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPIC 244 >4XUF-A nrPDB Length = 297 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 58/280 (20%), Positives = 110/280 (39%), Gaps = 32/280 (11%) Query: 5 SQFKQLEKLGNGTYATVYKGL-----NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKE 59 + + LG+G + V + VA+K +K ++ + E+ +M + Sbjct: 9 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQ 68 Query: 60 L-KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRG------------- 104 L HENIV L + L+FE+ DL Y+ S+ + Sbjct: 69 LGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEE 128 Query: 105 ----LELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGI 160 L + F +Q+ +G+ F +HRDL +N+L+ +K+ DFGLAR Sbjct: 129 DLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMS 188 Query: 161 PVNT--FSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQ 217 N + + + + AP+ L Y+ D+WS G +L E+ + G +PG + Sbjct: 189 DSNYVVRGNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDAN 247 Query: 218 LKLIFDIMGTPNESLWPS----VTKLPKYNPNIQQRPPRD 253 + ++ + + + + + ++RP Sbjct: 248 FYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFP 287 >5U6B-A nrPDB Length = 307 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 58/306 (18%), Positives = 109/306 (35%), Gaps = 47/306 (15%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTG--VYVALKEVKLD-SEEGTPSTAIREISLM 57 M + + LG G + V +G + VA+K +K+ + E M Sbjct: 19 MVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCM 78 Query: 58 KELKHENIVRLYDVIHTENKL------TLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLV 110 KE H N++RL V ++ ++ FM DL ++ +G+ P L ++ Sbjct: 79 KEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQML 138 Query: 111 KYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV 170 F + G+ + + +HRDL +N ++N+ + + DFGL++ + Sbjct: 139 VKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIA 198 Query: 171 --TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGT 227 + + A + L R Y++ D+WS G + E+ T G+ +PG + E + Sbjct: 199 KMPVKWIAIESL-ADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRL 257 Query: 228 PNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 + L + +LNP R S Sbjct: 258 KQPADC---------------------------------LDGLYALMSRCWELNPQDRPS 284 Query: 288 AKQALH 293 + Sbjct: 285 FTELRE 290 >4Y93-A nrPDB Length = 446 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 118/271 (43%), Gaps = 14/271 (5%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVY-VALKEVKLDSEEGTPSTAIREISLMKELK 61 L++LG G + V G K G Y VA+K +K S + I E +M L Sbjct: 186 DPKDLTFLKELGTGQFGVVKYG--KWRGQYDVAIKMIKEGSM--SEDEFIEEAKVMMNLS 241 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 HE +V+LY V + + ++ E+M N L Y+ + + + + Sbjct: 242 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMR-----HRFQTQQLLEMCKDVCEA 296 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLAR-AFGIPVNTFSSEVVTLWYRAPDV 179 + + + LHRDL +N L+N +G +K+ DFG+ R + + + + +P+V Sbjct: 297 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEV 356 Query: 180 LMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 LM S+ +S+ DIW+ G ++ E+ + GK + + E + I + P L Sbjct: 357 LMYSK-FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVY 415 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGN 269 Y+ ++ R ++L + + +D Sbjct: 416 AIMYSCWHEKADERPTFKILLSNILDVMDEE 446 >2PL0-A nrPDB Length = 289 Score = 204 bits (520), Expect = 3e-53, Method: Composition-based stats. Identities = 70/271 (25%), Positives = 126/271 (46%), Gaps = 19/271 (7%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 K +E+LG G + V+ G VA+K +K S +P + E +LMK+L+H+ +V Sbjct: 25 LKLVERLGAGQFGEVWMGYY-NGHTKVAVKSLKQGSM--SPDAFLAEANLMKQLQHQRLV 81 Query: 67 RLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 RLY V+ E + ++ E+M+ L ++ + + L +N + Q+ +G+AF Sbjct: 82 RLYAVVTQE-PIYIITEYMENGSLVDFLKT----PSGIKLTINKLLDMAAQIAEGMAFIE 136 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWYRAPDVLMGSR 184 E +HRDL+ N+L++ K+ DFGLAR + + AP+ + Sbjct: 137 ERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAI-NYG 195 Query: 185 TYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGT-----PNESLWPSVTK 238 T++ D+WS G +L E++T G+ +PG + E ++ + E L+ + Sbjct: 196 TFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRL 255 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGN 269 K P + RP D + + +G Sbjct: 256 CWKERP--EDRPTFDYLRSVLEDFFTATEGQ 284 >4E20-A nrPDB Length = 290 Score = 204 bits (519), Expect = 4e-53, Method: Composition-based stats. Identities = 65/291 (22%), Positives = 121/291 (41%), Gaps = 36/291 (12%) Query: 7 FKQLEKLGNGTYATV----YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 K++ LG G + V Y N TG VA+K +K S REI +++ L H Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYH 69 Query: 63 ENIVRLYDVIHTENK--LTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 E+IV+ + + + LV E++ L+ Y+ VG L + F Q+ + Sbjct: 70 EHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVG-------LAQLLLFAQQICE 122 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV---VTLWYRA 176 G+A+ H +HR L +N+L++ +K+GDFGLA+A + +++ A Sbjct: 123 GMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYA 182 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P+ L + Y + D+WS G L E++T +++ +++G + +V Sbjct: 183 PECLKECKFY-YASDVWSFGVTLYELLT-----YCDSNQSPHTKFTELIGHTQGQM--TV 234 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 +L + ++ P D + + + R + Sbjct: 235 LRLTELLERGERLPRPDR-----------CPCEIYHLMKNCWETEASFRPT 274 >5X02-A nrPDB Length = 347 Score = 204 bits (519), Expect = 4e-53, Method: Composition-based stats. Identities = 58/280 (20%), Positives = 110/280 (39%), Gaps = 32/280 (11%) Query: 5 SQFKQLEKLGNGTYATVYKGL-----NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKE 59 + + LG+G + V + VA+K +K ++ + E+ +M + Sbjct: 48 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQ 107 Query: 60 L-KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRG------------- 104 L HENIV L + L+FE+ DL Y+ S+ + Sbjct: 108 LGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEE 167 Query: 105 ----LELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGI 160 L + F +Q+ +G+ F +HRDL +N+L+ +K+ DFGLAR Sbjct: 168 DLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMS 227 Query: 161 PVNT--FSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQ 217 N + + + + AP+ L Y+ D+WS G +L E+ + G +PG + Sbjct: 228 DSNYVVRGNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDAN 286 Query: 218 LKLIFDIMGTPNESLWPS----VTKLPKYNPNIQQRPPRD 253 + ++ + + + + + ++RP Sbjct: 287 FYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFP 326 >6BXI-A nrPDB Length = 333 Score = 203 bits (518), Expect = 5e-53, Method: Composition-based stats. Identities = 66/341 (19%), Positives = 118/341 (34%), Gaps = 81/341 (23%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKH 62 F+ L+ +G G + V K TG A+K ++ E+ E ++ E Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 65 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 +V+++ + L L+ EF+ D T+ L +++ + + + Sbjct: 66 LWVVKMFYSFQDKLNLYLIMEFLPGG-----DMMTLLMKKDTLTEEETQFYIAETVLAID 120 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT------------------ 164 H+ +HRD+KP NLL++ +G +KL DFGL T Sbjct: 121 SIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 180 Query: 165 -----------------FSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKP 207 S V T Y AP+V M + Y+ D WS G I+ EM+ G P Sbjct: 181 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQT-GYNKLCDWWSLGVIMYEMLIGYP 239 Query: 208 LFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLD 267 F +E K + + ++ L + P+ Sbjct: 240 PFCSETPQETYKKVMN------------------------------WKETLTFPPEVPIS 269 Query: 268 GNLMDFLHG-LLQLNPDMRLSA---KQALHHPWFA--EYYH 302 D + + R+ A ++ + +F ++ H Sbjct: 270 EKAKDLILRFCCEWEH--RIGAPGVEEIKSNSFFEGVDWEH 308 >3G0E-A nrPDB Length = 336 Score = 203 bits (518), Expect = 5e-53, Method: Composition-based stats. Identities = 58/312 (18%), Positives = 110/312 (35%), Gaps = 57/312 (18%) Query: 5 SQFKQLEKLGNGTYATVYKG-----LNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKE 59 ++ + LG G + V + + + VA+K +K + + E+ ++ Sbjct: 46 NRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSY 105 Query: 60 L-KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVK------ 111 L H NIV L ++ E+ DL ++ + +++ Sbjct: 106 LGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELAL 165 Query: 112 ------YFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF 165 F +Q+ +G+AF +HRDL +N+L+ K+ DFGLAR N Sbjct: 166 DLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYV 225 Query: 166 --SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTN-DEEQLKLI 221 + + + + AP+ + Y+ D+WS G L E+ + G +PG D + K+I Sbjct: 226 VKGNARLPVKWMAPESIFNC-VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI 284 Query: 222 FDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLN 281 + + P + D + + Sbjct: 285 KEGFRMLSPEHAP---------------------------------AEMYDIMKTCWDAD 311 Query: 282 PDMRLSAKQALH 293 P R + KQ + Sbjct: 312 PLKRPTFKQIVQ 323 >3OMV-A nrPDB Length = 307 Score = 203 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 63/274 (22%), Positives = 130/274 (47%), Gaps = 21/274 (7%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKL-DSEEGTPSTAIREISLMKELKHENIVRLYD 70 ++G+G++ TVYKG VA+K +K+ D E++++++ +H NI+ Sbjct: 43 RIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMG 99 Query: 71 VIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 T++ L +V ++ + L K++ + ++ + Q QG+ + H I Sbjct: 100 -YMTKDNLAIVTQWCEGSSLYKHLHVQ-----ETKFQMFQLIDIARQTAQGMDYLHAKNI 153 Query: 130 LHRDLKPQNLLINKRGQLKLGDFGLA--RAFGIPVNTFSSEVVTLWYRAPDVL--MGSRT 185 +HRD+K N+ +++ +K+GDFGLA ++ ++ + AP+V+ + Sbjct: 154 IHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNP 213 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 +S D++S G +L E++TG+ + N+ +Q+ I P ++KL K P Sbjct: 214 FSFQSDVYSYGIVLYELMTGELPYSHINNRDQI-----IFMVGRGYASPDLSKLYKNCPK 268 Query: 246 IQQRPPRD-LRQVLQPHTKEPLDGNLMDFLHGLL 278 +R D +++V + P + ++ L L Sbjct: 269 AMKRLVADCVKKVKEERPLFPQILSSIELLQHSL 302 >4EQM-A nrPDB Length = 294 Score = 203 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 76/274 (27%), Positives = 129/274 (47%), Gaps = 12/274 (4%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALK--EVKLDSEEGTPSTAIREISLMKELK 61 + ++K ++KLG G +TVY + + VA+K + +E T RE+ +L Sbjct: 10 NERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLS 69 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H+NIV + DV ++ LV E+++ L +Y++S L ++ F Q+L G Sbjct: 70 HQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGP------LSVDTAINFTNQILDG 123 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV-VTLWYRAPDV 179 + H+ +I+HRD+KPQN+LI+ LK+ DFG+A+A T ++ V T+ Y +P+ Sbjct: 124 IKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQ 183 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQ-LKLIFDIMGTPNESLWPSVTK 238 G T DI+S G +L EM+ G+P F G +K I D + + + + Sbjct: 184 AKGEAT-DECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQ 242 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMD 272 + R K+ L L + Sbjct: 243 SLSNVILRATEKDKANRYKTIQEMKDDLSSVLHE 276 >5X5O-A nrPDB Length = 310 Score = 203 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 66/291 (22%), Positives = 117/291 (40%), Gaps = 52/291 (17%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 + E G G++ +VY+ + VA+K++ +E ++ L H N Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL---------LKIEKEAEILSVLSHRN 65 Query: 65 IVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 I++ Y VI +V E+ L Y++S N ++++ + + + +G+ + Sbjct: 66 IIQFYGVILEPPNYGIVTEYASLGSLYDYINS----NRSEEMDMDHIMTWATDVAKGMHY 121 Query: 124 CHEN---KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 H K++HRDLK +N++I G LK+ DFG +R T S V T + AP+V+ Sbjct: 122 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHN--HTTHMSLVGTFPWMAPEVI 179 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 S S + D +S G +L EM+T + F G + L+ + +P Sbjct: 180 Q-SLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVE---------KNERLTIP 229 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 P + + LH + + R S KQ Sbjct: 230 SSCP-----------------------RSFAELLHQCWEADAKKRPSFKQI 257 >1BYG-A nrPDB Length = 278 Score = 203 bits (517), Expect = 7e-53, Method: Composition-based stats. Identities = 61/248 (24%), Positives = 117/248 (47%), Gaps = 17/248 (6%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 + + K L+ +G G + V G + G VA+K +K D+ + E S+M +L+H Sbjct: 19 NMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATA---QAFLAEASVMTQLRH 73 Query: 63 ENIVRLYDVI-HTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 N+V+L VI + L +V E+M L Y+ SR L + + F + + Sbjct: 74 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS----VLGGDCLLKFSLDVCEA 129 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 + + N +HRDL +N+L+++ K+ DFGL + +T + + + AP+ L Sbjct: 130 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPEAL 186 Query: 181 MGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDI-MGTPNESLWPSVTK 238 + +ST D+WS G +L E+ + G+ +P ++ + + + P+V + Sbjct: 187 R-EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYE 245 Query: 239 LPKYNPNI 246 + K ++ Sbjct: 246 VMKNCWHL 253 >6DBN-A nrPDB Length = 316 Score = 203 bits (517), Expect = 8e-53, Method: Composition-based stats. Identities = 68/300 (22%), Positives = 123/300 (41%), Gaps = 40/300 (13%) Query: 7 FKQLEKLGNGTYATVYKGLNK----TTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 K++ LG G + V TG VA+K +K +S + +EI +++ L H Sbjct: 37 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYH 96 Query: 63 ENIVRLYDVIHTE--NKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 ENIV+ + + N + L+ EF+ LK+Y+ + L + Q+ + Sbjct: 97 ENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYL-----PKNKNKINLKQQLKYAVQICK 151 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS---SEVVTLWYRA 176 G+ + + +HRDL +N+L+ Q+K+GDFGL +A ++ +++ A Sbjct: 152 GMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYA 211 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQ---LKLIFDIMGTPNESLW 233 P+ LM S+ Y + D+WS G L E++T + ++ LK+I G + Sbjct: 212 PECLMQSKFY-IASDVWSFGVTLHELLT----YCDSDSSPMALFLKMIGPTHGQMTVTRL 266 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 + K K P P + + + P R S + + Sbjct: 267 VNTLKEGKRLPCPPNCP-----------------DEVYQLMRKCWEFQPSNRTSFQNLIE 309 >4WUA-A nrPDB Length = 401 Score = 203 bits (517), Expect = 8e-53, Method: Composition-based stats. Identities = 93/370 (25%), Positives = 160/370 (43%), Gaps = 86/370 (23%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH- 62 + ++ + KLG G ++TV+ + +VA+K VK S E TA+ EI L+K +++ Sbjct: 40 NGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK--SAEHYTETALDEIRLLKSVRNS 97 Query: 63 -EN------IVRLYDVIH----TENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVK 111 N +V+L D + +VFE + + L K++ + + +GL L VK Sbjct: 98 DPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWI----IKSNYQGLPLPCVK 153 Query: 112 YFQWQLLQGLAFCHEN-KILHRDLKPQNLLIN---------------------------- 142 Q+LQGL + H +I+H D+KP+N+L++ Sbjct: 154 KIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSA 213 Query: 143 ---------------------KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 ++ ++K+ D G A F+ ++ T YR+ +VL+ Sbjct: 214 VSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH---KHFTEDIQTRQYRSLEVLI 270 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTN------DEEQLKLIFDIMGTPNESLWPS 235 GS Y+T DIWS C+ E+ TG LF + DE+ + LI +++G L + Sbjct: 271 GS-GYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVA 329 Query: 236 VTKLPKYN------PNIQQRPPRDLRQVLQP--HTKEPLDGNLMDFLHGLLQLNPDMRLS 287 ++ +I + P L +VL + DFL +L+L P+ R + Sbjct: 330 GKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRAT 389 Query: 288 AKQALHHPWF 297 A + L HPW Sbjct: 390 AAECLRHPWL 399 >4HZS-A nrPDB Length = 341 Score = 203 bits (516), Expect = 9e-53, Method: Composition-based stats. Identities = 75/282 (26%), Positives = 121/282 (42%), Gaps = 21/282 (7%) Query: 6 QFKQLEKLGNGTYATVYKGL-NKTTGVYV--ALKEVKLD--SEEGTPSTAIREISLMKEL 60 + LEKLG+G++ V +G + +G V A+K +K D S+ IRE++ M L Sbjct: 13 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 72 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H N++RLY V+ T + +V E L + L + + Q+ + Sbjct: 73 DHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGH-----FLLGTLSRYAVQVAE 126 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF---SSEVVTLWYRA 176 G+ + + +HRDL +NLL+ R +K+GDFGL RA + + V + A Sbjct: 127 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 186 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI-FDIMGTPNESLWP 234 P+ L +RT+S + D W G L EM T G+ + G N + L I + P P Sbjct: 187 PESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCP 245 Query: 235 SVTK---LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDF 273 + + + RP + + L DF Sbjct: 246 QDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDF 287 >3HMP-A nrPDB Length = 342 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 74/312 (23%), Positives = 130/312 (41%), Gaps = 54/312 (17%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLMKELK--HE 63 + L+++G+G + V++ LN A+K V L+ + + R EI+ + +L+ + Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 I+RLYD T+ + +V E + DL ++ + + ++ K + +L+ + Sbjct: 117 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKK------KSIDPWERKSYWKNMLEAVHT 170 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVTLWYRAPDVLM 181 H++ I+H DLKP N LI G LKL DFG+A + S+V T+ Y P+ + Sbjct: 171 IHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 229 Query: 182 G----------SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 S D+WS GCIL M GK F ++ + I + + + Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-----QQIINQISKLHAIIDPN 284 Query: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 +P+ +L D L L+ +P R+S + Sbjct: 285 HEIEFPDIPE--------------------------KDLQDVLKCCLKRDPKQRISIPEL 318 Query: 292 LHHPWFAEYYHH 303 L HP+ H Sbjct: 319 LAHPYVQIQTHP 330 >1AD5-A nrPDB Length = 438 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 65/250 (26%), Positives = 119/250 (47%), Gaps = 25/250 (10%) Query: 7 FKQLEKLGNGTYATVYKG-LNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 K +KLG G + V+ NK T VA+K +K S + + E ++MK L+H+ + Sbjct: 184 LKLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSM--SVEAFLAEANVMKTLQHDKL 239 Query: 66 VRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 V+L+ V+ T+ + ++ EFM L ++ S P L + F Q+ +G+AF Sbjct: 240 VKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQP----LPKLIDFSAQIAEGMAFI 294 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 + +HRDL+ N+L++ K+ DFGLAR + + AP+ + Sbjct: 295 EQRNYIHRDLRAANILVSASLVCKIADFGLARV---------GAKFPIKWTAPEAI-NFG 344 Query: 185 TYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK---LP 240 +++ D+WS G +L E++T G+ +PG ++ E ++ + P P + Sbjct: 345 SFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMR 404 Query: 241 KYNPNIQQRP 250 + ++RP Sbjct: 405 CWKNRPEERP 414 >2OZO-A nrPDB Length = 613 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 58/248 (23%), Positives = 110/248 (44%), Gaps = 19/248 (7%) Query: 12 KLGNGTYATVYKGLNKTTGVY--VALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 +LG G + +V +G+ + VA+K +K +E+ +RE +M +L + IVRL Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 Query: 70 DVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 V E L LV E L K++ + + ++ V Q+ G+ + E Sbjct: 403 GVCQAE-ALMLVMEMAGGGPLHKFLVGKR-----EEIPVSNVAELLHQVSMGMKYLEEKN 456 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLMGSRT 185 +HR+L +N+L+ R K+ DFGL++A G + +++ W + AP+ + R Sbjct: 457 FVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRK 515 Query: 186 YSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI-----FDIMGTPNESLWPSVTKL 239 +S+ D+WS G + E ++ G+ + E + I + L+ ++ Sbjct: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDC 575 Query: 240 PKYNPNIQ 247 Y + Sbjct: 576 WIYKWEDR 583 >1U59-A nrPDB Length = 287 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 59/248 (23%), Positives = 110/248 (44%), Gaps = 19/248 (7%) Query: 12 KLGNGTYATVYKGLNKTTGVY--VALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 +LG G + +V +G+ + VA+K +K +E+ +RE +M +L + IVRL Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 76 Query: 70 DVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 V E L LV E L K++ + + ++ V Q+ G+ + E Sbjct: 77 GVCQAE-ALMLVMEMAGGGPLHKFLVGKR-----EEIPVSNVAELLHQVSMGMKYLEEKN 130 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLMGSRT 185 +HRDL +N+L+ R K+ DFGL++A G + +++ W + AP+ + R Sbjct: 131 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRK 189 Query: 186 YSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI-----FDIMGTPNESLWPSVTKL 239 +S+ D+WS G + E ++ G+ + E + I + L+ ++ Sbjct: 190 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDC 249 Query: 240 PKYNPNIQ 247 Y + Sbjct: 250 WIYKWEDR 257 >5UUU-A nrPDB Length = 547 Score = 202 bits (514), Expect = 1e-52, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 122/306 (39%), Gaps = 50/306 (16%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKEL 60 + + F +G G + VY TG A+K + K + + A+ E ++ + Sbjct: 196 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 255 Query: 61 ---KHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 IV + HT +KL+ + + M DL ++ V ++++ + Sbjct: 256 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV------FSEADMRFYAAE 309 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 ++ GL H +++RDLKP N+L+++ G +++ D GLA F + V T Y A Sbjct: 310 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVGTHGYMA 367 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P+VL Y +S D +S GC+L +++ G F +++ ++ Sbjct: 368 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI---------------- 411 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQA 291 + + + L L GLLQ + + RL A++ Sbjct: 412 ---------------DRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEV 456 Query: 292 LHHPWF 297 P+F Sbjct: 457 KESPFF 462 >2X7G-A nrPDB Length = 389 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 92/368 (25%), Positives = 155/368 (42%), Gaps = 84/368 (22%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-- 61 + ++ + KLG G ++TV+ + +VA+K VK S + TA+ EI L+K ++ Sbjct: 30 NGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK--SAQHYTETALDEIKLLKCVRES 87 Query: 62 ---HEN---IVRLYDVIHTEN----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVK 111 N +V+L D + +VFE + + L K++ + + +GL + VK Sbjct: 88 DPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWI----IKSNYQGLPVRCVK 143 Query: 112 YFQWQLLQGLAFCHEN-KILHRDLKPQNLLINKRG------------------------- 145 Q+LQGL + H KI+H D+KP+N+L+ Sbjct: 144 SIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSA 203 Query: 146 ----------------------QLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGS 183 ++K+ D G A F+ ++ T YR+ +VL+G+ Sbjct: 204 VSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVH---KHFTEDIQTRQYRSIEVLIGA 260 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTN------DEEQLKLIFDIMGTPNESLWPSVT 237 YST DIWS C+ E+ TG LF + DE+ + I +++G+ S Sbjct: 261 -GYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGK 319 Query: 238 KLPKYNP------NIQQRPPRDLRQVLQPHTKEPLDG--NLMDFLHGLLQLNPDMRLSAK 289 ++ +I + P L VL P + DFL +L++ P+ R SA Sbjct: 320 YSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAG 379 Query: 290 QALHHPWF 297 + L HPW Sbjct: 380 ECLRHPWL 387 >3PVW-A nrPDB Length = 695 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 122/306 (39%), Gaps = 50/306 (16%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKEL 60 + + F +G G + VY TG A+K + K + + A+ E ++ + Sbjct: 187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLV 246 Query: 61 ---KHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 IV + HT +KL+ + + M DL ++ V ++++ + Sbjct: 247 STGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV------FSEADMRFYAAE 300 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 ++ GL H +++RDLKP N+L+++ G +++ D GLA F + V T Y A Sbjct: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVGTHGYMA 358 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 P+VL Y +S D +S GC+L +++ G F +++ ++ Sbjct: 359 PEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEI---------------- 402 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQA 291 + + + L L GLLQ + + RL A++ Sbjct: 403 ---------------DRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEV 447 Query: 292 LHHPWF 297 P+F Sbjct: 448 KESPFF 453 >4YHJ-A nrPDB Length = 584 Score = 201 bits (511), Expect = 3e-52, Method: Composition-based stats. Identities = 66/305 (21%), Positives = 114/305 (37%), Gaps = 42/305 (13%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGT--PSTAIREISLMKEL 60 + + F+ LG G + V + TG A K+++ + + A+ E +++++ Sbjct: 183 TKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV 242 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 + +V L T++ L LV M+ + G + ++ +L G Sbjct: 243 QSRFVVSLAYAYETKDALCLVLTIMNGG---DLKFHIYNLGNPGFDEQRAVFYAAELCCG 299 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL 180 L +I++RDLKP+N+L++ RG +++ D GLA V T+ Y AP+V+ Sbjct: 300 LEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIP-EGQRVRGRVGTVGYMAPEVV 358 Query: 181 MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 + Y+ S D W GC++ EMI G F Sbjct: 359 -NNEKYTFSPDWWGLGCLIYEMIQGHSPF------------------------------K 387 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALHHP 295 KY ++ + E + LL NP RL A HP Sbjct: 388 KYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHP 447 Query: 296 WFAEY 300 F + Sbjct: 448 VFKDI 452 >4KIK-B nrPDB Length = 677 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 73/290 (25%), Positives = 124/290 (42%), Gaps = 25/290 (8%) Query: 8 KQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVR 67 + E+LG G + V + N+ TG +A+K+ + + EI +M+ L H N+V Sbjct: 22 EMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVA 81 Query: 68 LYDVIHTENKL------TLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 DV L L E+ DL+KY++ GL + + Sbjct: 82 ARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQ---FENCCGLREGAILTLLSDIASA 138 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQL---KLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 L + HEN+I+HRDLKP+N+++ + Q K+ D G A+ + +S V TL Y AP Sbjct: 139 LRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQ-GSLCTSFVGTLQYLAP 197 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 ++L + Y+ ++D WS G + E ITG F Q + + + Sbjct: 198 ELLEQQK-YTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLN 256 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 K++ ++ P +L VL ++ L +L +P R + Sbjct: 257 GTVKFSSSLPY--PNNLNSVLAERLEKW--------LQLMLMWHPRQRGT 296 >4XI2-A nrPDB Length = 446 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 65/273 (23%), Positives = 121/273 (44%), Gaps = 18/273 (6%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVY-VALKEVKLDSEEGTPSTAIREISLMKELK 61 L++LG G + V G K G Y VA+K ++ S + I E +M L Sbjct: 185 DPKDLTFLKELGTGQFGVVKYG--KWRGQYDVAIKMIREGSM--SEDEFIEEAKVMMNLS 240 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 HE +V+LY V + + ++ E+M N L Y+ + + + + Sbjct: 241 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMR-----HRFQTQQLLEMCKDVCEA 295 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV---TLWYRAP 177 + + + LHRDL +N L+N +G +K+ DFGL+R + + ++S V + + P Sbjct: 296 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRY--VLDDEYTSSVGSKFPVRWSPP 353 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 +VLM S+ +S+ DIW+ G ++ E+ + GK + + E + I + L Sbjct: 354 EVLMYSK-FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASER 412 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGN 269 Y+ ++ R ++L + + +D Sbjct: 413 VYTIMYSCWHEKADERPSFKILLSNILDVMDEE 445 >5FM2-A nrPDB Length = 355 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 58/269 (21%), Positives = 114/269 (42%), Gaps = 33/269 (12%) Query: 9 QLEKLGNGTYATVYKG-----LNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 + LG G + V K + VA+K +K ++ + E +++K++ H Sbjct: 68 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHP 127 Query: 64 NIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTV------------------GNTPRG 104 ++++LY + L L+ E+ L+ ++ R Sbjct: 128 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 187 Query: 105 LELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT 164 L + + F WQ+ QG+ + E K++HRDL +N+L+ + ++K+ DFGL+R + Sbjct: 188 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 247 Query: 165 FSSEVV--TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 + + A + L Y+T D+WS G +L E++T G +PG E L+ Sbjct: 248 VKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLL 306 Query: 222 -----FDIMGTPNESLWPSVTKLPKYNPN 245 + +E ++ + + K P+ Sbjct: 307 KTGHRMERPDNCSEEMYRLMLQCWKQEPD 335 >5AP3-A nrPDB Length = 313 Score = 200 bits (509), Expect = 6e-52, Method: Composition-based stats. Identities = 74/312 (23%), Positives = 130/312 (41%), Gaps = 54/312 (17%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLMKELK--HE 63 + L+++G+G + V++ LN A+K V L+ + + R EI+ + +L+ + Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 I+RLYD T+ + +V E + DL ++ + + ++ K + +L+ + Sbjct: 89 KIIRLYDYEITDQYIYMVMECGNIDLNGWLKKK------KSIDPWERKSYWKNMLEAVHT 142 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVTLWYRAPDVLM 181 H++ I+H DLKP N LI G LKL DFG+A + S+V T+ Y P+ + Sbjct: 143 IHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 201 Query: 182 G----------SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 S D+WS GCIL M GK F ++ + I + + + Sbjct: 202 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-----QQIINQISKLHAIIDPN 256 Query: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 +P+ +L D L L+ +P R+S + Sbjct: 257 HEIEFPDIPE--------------------------KDLQDVLKCCLKRDPKQRISIPEL 290 Query: 292 LHHPWFAEYYHH 303 L HP+ H Sbjct: 291 LAHPYVQIQTHP 302 >2ZMD-A nrPDB Length = 390 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 73/312 (23%), Positives = 129/312 (41%), Gaps = 54/312 (17%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIR-EISLMKELK--HE 63 + L+++G+G + V++ LN A+K V L+ + + R EI+ + +L+ + Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 I+RLYD T+ + +V E + DL ++ + + ++ K + +L+ + Sbjct: 117 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKK------KSIDPWERKSYWKNMLEAVHT 170 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVTLWYRAPDVLM 181 H++ I+H DLKP N LI G LKL DFG+A + S+V + Y P+ + Sbjct: 171 IHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIK 229 Query: 182 G----------SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 S D+WS GCIL M GK F ++ + I + + + Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF-----QQIINQISKLHAIIDPN 284 Query: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 +P+ +L D L L+ +P R+S + Sbjct: 285 HEIEFPDIPE--------------------------KDLQDVLKCCLKRDPKQRISIPEL 318 Query: 292 LHHPWFAEYYHH 303 L HP+ H Sbjct: 319 LAHPYVQIQTHP 330 >6E4F-A nrPDB Length = 290 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 66/273 (24%), Positives = 121/273 (44%), Gaps = 18/273 (6%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVY-VALKEVKLDSEEGTPSTAIREISLMKELK 61 L++LG G + V G K G Y VA+K +K S + I E +M L Sbjct: 29 DPKDLTFLKELGTGQFGVVKYG--KWRGQYDVAIKMIKEGSM--SEDEFIEEAKVMMNLS 84 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 HE +V+LY V + + ++ E+M N L Y+ + + + + Sbjct: 85 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMR-----HRFQTQQLLEMCKDVCEA 139 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV---TLWYRAP 177 + + + LHRDL +N L+N +G +K+ DFGL+R + + ++S V + + P Sbjct: 140 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRY--VLDDEYTSSVGSKFPVRWSPP 197 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 +VLM S+ +S+ DIW+ G ++ E+ + GK + + E + I + L Sbjct: 198 EVLMYSK-FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEK 256 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGN 269 Y+ ++ R ++L + + +D Sbjct: 257 VYTIMYSCWHEKADERPTFKILLSNILDVMDEE 289 >5GRN-A nrPDB Length = 356 Score = 200 bits (508), Expect = 9e-52, Method: Composition-based stats. Identities = 70/306 (22%), Positives = 121/306 (39%), Gaps = 40/306 (13%) Query: 9 QLEKLGNGTYATVYKGL-----NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-H 62 LG+G + V +G + VA+K +K + + E+ +M L H Sbjct: 50 LGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPH 109 Query: 63 ENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVG--------------------NT 101 NIV L + ++ E+ DL Y+ + Sbjct: 110 LNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDN 169 Query: 102 PRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIP 161 GL L + F +Q+ +G+ F +HRDL +N+L+ + +K+ DFGLAR Sbjct: 170 SEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHD 229 Query: 162 VNTFS--SEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPG-TNDEEQ 217 N S S + + + AP+ + + Y+T D+WS G +L E+ + G +PG D Sbjct: 230 SNYVSKGSTFLPVKWMAPESIFDN-LYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTF 288 Query: 218 LKLIFDI--MGTPNESLWPSVTKLPK-YNPNIQQRP-----PRDLRQVLQPHTKEPLDGN 269 I M P+ + + K +N ++RP + +L K+ + Sbjct: 289 YNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKI 348 Query: 270 LMDFLH 275 +DFL Sbjct: 349 HLDFLK 354 >5GNK-A nrPDB Length = 297 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 55/237 (23%), Positives = 109/237 (45%), Gaps = 15/237 (6%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYV----ALKEVKLDSEEGTPSTAIREISLMKEL 60 ++FK+++ LG+G + TVYKGL G V A+KE++ + + E +M + Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 78 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 + ++ RL + T + L+ + M L Y+ + L + Q+ + Sbjct: 79 DNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDNIGSQYL-----LNWCVQIAK 132 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV--TLWYRAP 177 G+ + + +++HRDL +N+L+ +K+ DFGLA+ G + +E + + A Sbjct: 133 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMAL 192 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 + ++ R Y+ D+WS G + E++T G + G E ++ P + Sbjct: 193 ESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPIC 248 >5HLW-A nrPDB Length = 299 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 61/274 (22%), Positives = 118/274 (43%), Gaps = 20/274 (7%) Query: 11 EKLGNGTYATVYKGL---NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVR 67 E +G G + VY G N ++ A+K + ++ G S + E +MK+ H N++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLS 85 Query: 68 LYDVI-HTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 L + +E +V +M DL+ ++ + T T + L F Q+ +G+ + Sbjct: 86 LLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDL-----IGFGLQVAKGMKYLA 140 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGI----PVNTFSSEVVTLWYRAPDVLM 181 K +HRDL +N +++++ +K+ DFGLAR V+ + + + + A + L Sbjct: 141 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQ 200 Query: 182 GSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 + ++T D+WS G +L E++T G P +P N + + P P Sbjct: 201 TQK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPD----P 255 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFL 274 Y ++ P+ + + F+ Sbjct: 256 LYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFI 289 >3C1X-A nrPDB Length = 373 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 62/274 (22%), Positives = 118/274 (43%), Gaps = 20/274 (7%) Query: 11 EKLGNGTYATVYKGL---NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVR 67 E +G G + VY G N ++ A+K + ++ G S + E +MK+ H N++ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLS 154 Query: 68 LYDVI-HTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 L + +E +V +M DL+ ++ + T T + L F Q+ +G+ F Sbjct: 155 LLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDL-----IGFGLQVAKGMKFLA 209 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFG----IPVNTFSSEVVTLWYRAPDVLM 181 K +HRDL +N +++++ +K+ DFGLAR V+ + + + + A + L Sbjct: 210 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQ 269 Query: 182 GSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 + ++T D+WS G +L E++T G P +P N + + P P Sbjct: 270 TQK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPD----P 324 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFL 274 Y ++ P+ + + F+ Sbjct: 325 LYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFI 358 >4CRS-A nrPDB Length = 341 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 70/303 (23%), Positives = 122/303 (40%), Gaps = 53/303 (17%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKL-----DSEEGTPSTAIREISLMKEL 60 F+ L G + V K T A+K +K E + R + + Sbjct: 13 DFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSV 72 Query: 61 KHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 +H +V L+ T+ + V E+ DL ++ + ++ ++ Sbjct: 73 RHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-------DVFSEPRAVFYAACVVL 125 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 GL + HE+KI++RDLK NLL++ G +K+ DFGL + + S+ T + AP+V Sbjct: 126 GLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 185 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 L +Y+ ++D W G ++ EM+ G+ FPG ++EE I + +E +P Sbjct: 186 L-TETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN-----DEVRYPRF--- 236 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ-----ALHH 294 L + + LL+ NP+ RL A + H Sbjct: 237 --------------------------LSTEAISIMRRLLRRNPERRLGASEKDAEDVKKH 270 Query: 295 PWF 297 P+F Sbjct: 271 PFF 273 >3SXS-A nrPDB Length = 268 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 65/271 (23%), Positives = 121/271 (44%), Gaps = 18/271 (6%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVY-VALKEVKLDSEEGTPSTAIREISLMKELKHE 63 + L++LG+G + V G K G Y VA+K +K S + +E M +L H Sbjct: 8 EEITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSM--SEDEFFQEAQTMMKLSHP 63 Query: 64 NIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 +V+ Y V E + +V E++ N L Y+ S +GLE + + + + +G+A Sbjct: 64 KLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHG-----KGLEPSQLLEMCYDVCEGMA 118 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTL---WYRAPDV 179 F ++ +HRDL +N L+++ +K+ DFG+ R + + + S V T + AP+V Sbjct: 119 FLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRY--VLDDQYVSSVGTKFPVKWSAPEV 176 Query: 180 LMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 + YS+ D+W+ G ++ E+ + GK + + E + + L Sbjct: 177 FHYFK-YSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIY 235 Query: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGN 269 Y+ + R Q L + + + Sbjct: 236 QIMYSCWHELPEKRPTFQQLLSSIEPLREKD 266 >3ZBF-A nrPDB Length = 322 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 108/291 (37%), Gaps = 50/291 (17%) Query: 13 LGNGTYATVYKG-----LNKTTGV-YVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 LG+G + VY+G L +G VA+K +K S + ++E LM + H NI+ Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNIL 100 Query: 67 RLYDVIHTENKLTLVFEFMD-NDLKKYMDS-RTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 + V ++ E M+ DL Y+ R L L + + +G + Sbjct: 101 KQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYL 160 Query: 125 HENKILHRDLKPQNLLINKRGQ-----LKLGDFGLARAFGIPVNTFSSEVV--TLWYRAP 177 +HRDL +N L++ + +K+GDFGLAR + + AP Sbjct: 161 ERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAP 220 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 + LM ++T D+WS G ++ E++T G +P ++ + L + P Sbjct: 221 ESLMDG-IFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPD- 278 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 +L + + PD R + Sbjct: 279 --------------------------------DLWNLMTQCWAQEPDQRPT 297 >3LZB-A nrPDB Length = 327 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 55/237 (23%), Positives = 109/237 (45%), Gaps = 15/237 (6%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYV----ALKEVKLDSEEGTPSTAIREISLMKEL 60 ++FK+++ LG+G + TVYKGL G V A+KE++ + + E +M + Sbjct: 15 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 74 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 + ++ RL + T + L+ + M L Y+ + L + Q+ + Sbjct: 75 DNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYL-----LNWCVQIAK 128 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV--TLWYRAP 177 G+ + + +++HRDL +N+L+ +K+ DFGLA+ G + +E + + A Sbjct: 129 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMAL 188 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 + ++ R Y+ D+WS G + E++T G + G E ++ P + Sbjct: 189 ESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPIC 244 >1U54-B nrPDB Length = 291 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 75/280 (26%), Positives = 120/280 (42%), Gaps = 22/280 (7%) Query: 6 QFKQLEKLGNGTYATVYKGL-NKTTGVYV--ALKEVKLD--SEEGTPSTAIREISLMKEL 60 + LEKLG+G++ V +G + +G V A+K +K D S+ IRE++ M L Sbjct: 19 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 78 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H N++RLY V+ T + +V E L + L + + Q+ + Sbjct: 79 DHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGH-----FLLGTLSRYAVQVAE 132 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF---SSEVVTLWYRA 176 G+ + + +HRDL +NLL+ R +K+GDFGL RA + + V + A Sbjct: 133 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 192 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI-FDIMGTPNESLWP 234 P+ L +RT+S + D W G L EM T G+ + G N + L I + P P Sbjct: 193 PESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCP 251 Query: 235 SVTK---LPKYNPNIQQRPP-RDLRQVLQPHTKEPLDGNL 270 + + + RP LR L + Sbjct: 252 QDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRAEF 291 >5B2L-A nrPDB Length = 324 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 58/304 (19%), Positives = 115/304 (37%), Gaps = 44/304 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISL-MKELKHE 63 + + L ++G+GT V+K + TG +A+K+++ + + ++ + +K Sbjct: 17 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 76 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 IV+ + T + + E M +K + R G P ++ +++ L + Sbjct: 77 YIVQCFGTFITNTDVFIAMELMGTSAEK-LKKRMQGPIP----ERILGKMTVAIVKALYY 131 Query: 124 C-HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM- 181 ++ ++HRD+KP N+L+++RGQ+KL DFG++ + + Y AP+ + Sbjct: 132 LKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRL-VDSKAKTRSAGCAAYMAPERIDP 190 Query: 182 ---GSRTYSTSIDIWSCGCILAEMITGKPLFPGT-NDEEQLKLIFDIMGTPNESLWPSVT 237 Y D+WS G L E+ TG+ + D E L + Sbjct: 191 PDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ-------------- 236 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 + G+ F+ L + R + L H + Sbjct: 237 -----------------EEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFI 279 Query: 298 AEYY 301 Y Sbjct: 280 KRYE 283 >3DLS-A nrPDB Length = 335 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 124/307 (40%), Gaps = 60/307 (19%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-------EEGTPSTAIREISL 56 S ++ + LG+G + V+ ++K V +K +K + E+ EI++ Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI 82 Query: 57 MKELKHENIVRLYDVIHTENKLTLVFEFMDN--DLKKYMDSRTVGNTPRGLELNLVKYFQ 114 + ++H NI+++ D+ + LV E + DL ++D L+ L Y Sbjct: 83 LSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPR------LDEPLASYIF 136 Query: 115 WQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 QL+ + + I+HRD+K +N++I + +KL DFG A F + T+ Y Sbjct: 137 RQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLER-GKLFYTFCGTIEY 195 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 AP+VLMG+ +++WS G L ++ + F Sbjct: 196 CAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPF------------------------- 230 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEP--LDGNLMDFLHGLLQLNPDMRLSAKQAL 292 +L + ++ P + LM + GLLQ P+ R + ++ + Sbjct: 231 -----------------CELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLV 273 Query: 293 HHPWFAE 299 PW + Sbjct: 274 TDPWVTQ 280 >2JD5-A nrPDB Length = 373 Score = 197 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 87/332 (26%), Positives = 149/332 (44%), Gaps = 46/332 (13%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 +++ + KLG G ++TV+ + +VA+K V+ D + A EI L++ + Sbjct: 18 DARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGD--KVYTEAAEDEIKLLQRVNDA 75 Query: 64 -----------NIVRLYDVIHTEN----KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELN 108 +I++L D + + + +VFE + +L + RG+ L Sbjct: 76 DNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKY----EHRGIPLI 131 Query: 109 LVKYFQWQLLQGLAFCHEN-KILHRDLKPQNLLINKRG------QLKLGDFGLARAFGIP 161 VK QLL GL + H I+H D+KP+N+L+ Q+K+ D G A + Sbjct: 132 YVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYD-- 189 Query: 162 VNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG------TNDE 215 +++ + T YR+P+VL+G+ + DIWS C++ E+ITG LF T D+ Sbjct: 190 -EHYTNSIQTREYRSPEVLLGA-PWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDD 247 Query: 216 EQLKLIFDIMGTPNESLWPSVTKLPKYNP------NIQQRPPRDLRQVLQPHTKEPLDG- 268 + + I +++G L + + NI + L VL K D Sbjct: 248 DHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEA 307 Query: 269 -NLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 + DFL +LQL+P R A ++HPW + Sbjct: 308 KEISDFLSPMLQLDPRKRADAGGLVNHPWLKD 339 >4M7I-A nrPDB Length = 299 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 116/272 (42%), Gaps = 34/272 (12%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 + F+ ++ LG G + V++ NK A+K ++L + E +RE+ + +L+H Sbjct: 5 TDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 64 Query: 65 IVRLYDVIHTEN------------KLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVK 111 IVR ++ +N L + + +LK +M+ R T E ++ Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRC---TIEERERSVCL 121 Query: 112 YFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT------- 164 + Q+ + + F H ++HRDLKP N+ +K+GDFGL A Sbjct: 122 HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPM 181 Query: 165 -----FSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLK 219 + +V T Y +P+ + G+ +YS +DI+S G IL E++ +P + E+++ Sbjct: 182 PAYARHTGQVGTKLYMSPEQIHGN-SYSHKVDIFSLGLILFELL-----YPFSTQMERVR 235 Query: 220 LIFDIMGTPNESLWPSVTKLPKYNPNIQQRPP 251 + D+ L+ P Sbjct: 236 TLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPS 267 >5TOS-A nrPDB Length = 395 Score = 197 bits (501), Expect = 5e-51, Method: Composition-based stats. Identities = 72/305 (23%), Positives = 125/305 (40%), Gaps = 34/305 (11%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKT---------TGVYVALKEVKLDSEEGTPSTAIRE 53 ++ F+ +G G + V+KG TG+ +A+K++ + +G + E Sbjct: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG-HREWLTE 121 Query: 54 ISLMKELKHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKY 112 I+ + +L H N+V+L + LV+EFM L+ ++ R P L L Sbjct: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP--LPWFLRVN 179 Query: 113 FQWQLLQGLAFCHEN--KILHRDLKPQNLLINKRGQLKLGDFGLARA--FGIPVNTFSSE 168 +GLAF H + K+++RD+K N+L++ KL DFGLAR G + Sbjct: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 Query: 169 VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTP 228 + T Y AP+ M S + D++S G +L E+++GK ++ L+ Sbjct: 240 MGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV------- 291 Query: 229 NESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA 288 + P +T K + R L P + + L P R + Sbjct: 292 -DWARPYLTSKRKVLLIVDNR----LDTQYLPEEAVRMASVAV----QCLSFEPKSRPTM 342 Query: 289 KQALH 293 Q + Sbjct: 343 DQVVR 347 >3QA8-A nrPDB Length = 676 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 74/293 (25%), Positives = 127/293 (43%), Gaps = 25/293 (8%) Query: 8 KQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVR 67 + E+LG G + V + +++ TG VA+K+ + + EI +MK+L H N+V Sbjct: 17 EMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVVS 76 Query: 68 LYDVIHTENKL------TLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +V KL L E+ + DL+KY++ GL+ ++ + Sbjct: 77 AREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQ---FENCCGLKEGPIRTLLSDISSA 133 Query: 121 LAFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 L + HEN+I+HRDLKP+N+++ +R K+ D G A+ + V TL Y AP Sbjct: 134 LRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQ-GELCTEFVGTLQYLAP 192 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 ++L + Y+ ++D WS G + E ITG F Q + ++ +T Sbjct: 193 ELLEQ-KKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEHIVVYDDLT 251 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 K++ + H L G L +L +L + R + Q Sbjct: 252 GAVKFSSVLPT----------PNHLSGILAGKLERWLQCMLMWHQRQRGTDPQ 294 >3QUP-A nrPDB Length = 323 Score = 196 bits (499), Expect = 8e-51, Method: Composition-based stats. Identities = 57/296 (19%), Positives = 108/296 (36%), Gaps = 48/296 (16%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTG---VYVALKEVKLDSEEGTP-STAIREISLMKELK 61 QF LG G + +V + K V VA+K +K D + +RE + MKE Sbjct: 24 QFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFD 83 Query: 62 HENIVRLYDVI---HTENKL---TLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQ 114 H ++ +L V + +L ++ FM DL ++ + +G P L L + F Sbjct: 84 HPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFM 143 Query: 115 WQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVTL 172 + G+ + +HRDL +N ++ + + + DFGL+R + + + Sbjct: 144 VDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPV 203 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNES 231 + A + L + Y+ D+W+ G + E++T G+ + G + E + Sbjct: 204 KWLALESLADN-LYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPP 262 Query: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 + D ++ +P R S Sbjct: 263 ECM---------------------------------EEVYDLMYQCWSADPKQRPS 285 >5UIU-A nrPDB Length = 323 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 64/201 (31%), Positives = 97/201 (48%), Gaps = 11/201 (5%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLD---SEEGTPSTAIREISLMKELKHENIVRL 68 K+G G + VYKG T VA+K++ + E +EI +M + +HEN+V L Sbjct: 54 KMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 69 YDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 + L LV+ +M N +D + + L ++ G+ F HEN Sbjct: 112 LGFSSDGDDLCLVYVYMPNG--SLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENH 169 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE--VVTLWYRAPDVLMGSRTY 186 +HRD+K N+L+++ K+ DFGLARA T + V T Y AP+ L G Sbjct: 170 HIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE--I 227 Query: 187 STSIDIWSCGCILAEMITGKP 207 + DI+S G +L E+ITG P Sbjct: 228 TPKSDIYSFGVVLLEIITGLP 248 >3PP0-A nrPDB Length = 338 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 53/267 (19%), Positives = 112/267 (41%), Gaps = 15/267 (5%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGV----YVALKEVKLDSEEGTPSTAIREISLMKEL 60 ++ ++++ LG+G + TVYKG+ G VA+K ++ ++ + E +M + Sbjct: 17 TELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGV 76 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 + RL + T + LV + M L ++ + L + Q+ + Sbjct: 77 GSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDL-----LNWCMQIAK 130 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV--TLWYRAP 177 G+++ + +++HRDL +N+L+ +K+ DFGLAR I + ++ + + A Sbjct: 131 GMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMAL 190 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 + ++ R ++ D+WS G + E++T G + G E L+ P + Sbjct: 191 ESILRRR-FTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTID 249 Query: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTK 263 + + R + L Sbjct: 250 VYMIMVKCWMIDSECRPRFRELVSEFS 276 >1ZXE-A nrPDB Length = 303 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 71/322 (22%), Positives = 128/322 (39%), Gaps = 67/322 (20%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 +S F+++ LG G + V K N Y A+K+++ E+ ST + E+ L+ L H+ Sbjct: 5 ASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEK--LSTILSEVMLLASLNHQ 62 Query: 64 NIVRLYDVIHT-------------ENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNL 109 +VR Y ++ L + E+ +N L + S + + Sbjct: 63 YVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQR-----DE 117 Query: 110 VKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFG---------- 159 Q+L+ L++ H I+HR+LKP N+ I++ +K+GDFGLA+ Sbjct: 118 YWRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDS 177 Query: 160 ----IPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDE 215 + +S + T Y A +VL G+ Y+ ID++S G I EMI +P + Sbjct: 178 QNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI-----YPFSTGM 232 Query: 216 EQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLH 275 E++ ++ + E P + + Sbjct: 233 ERVNILKKLRSVSIE---------------------------FPPDFDDNKMKVEKKIIR 265 Query: 276 GLLQLNPDMRLSAKQALHHPWF 297 L+ +P+ R A+ L+ W Sbjct: 266 LLIDHDPNKRPGARTLLNSGWL 287 >5U6C-A nrPDB Length = 315 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 60/273 (21%), Positives = 108/273 (39%), Gaps = 14/273 (5%) Query: 9 QLEKLGNGTYATVYKGLNKT---TGVYVALKEVKLD-SEEGTPSTAIREISLMKELKHEN 64 + LG G + +V +G K T + VA+K +KLD S + + E + MK+ H N Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPN 99 Query: 65 IVRLYDVIHTE-----NKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 ++RL V K ++ FM DL Y+ + P+ + L + F + Sbjct: 100 VMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIA 159 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV--TLWYRA 176 G+ + LHRDL +N ++ + + DFGL++ + + + A Sbjct: 160 LGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIA 219 Query: 177 PDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 + L R Y++ D+W+ G + E+ T G +PG + E + Sbjct: 220 IESL-ADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLD 278 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDG 268 Y+ R VL+ ++ L+ Sbjct: 279 ELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLES 311 >4LFI-A nrPDB Length = 374 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 86/340 (25%), Positives = 166/340 (48%), Gaps = 53/340 (15%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVAL------------------------KE 37 +++ ++ K+G G Y+ V++G+ + V + + K Sbjct: 37 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKV 96 Query: 38 VK--LDSEEGTPSTAIREISLMKELK----------HENIVRLYDVIHTE--NKLTLVFE 83 L ++ T +E ++K ++ H NI+ L+D+I LVFE Sbjct: 97 PPTTLPFQKDQYYTNQKE-DVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 155 Query: 84 FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLIN- 142 ++DN + + L ++++ ++LL+ L +CH I+HRD+KP N++I+ Sbjct: 156 YVDNVDFRIL--------YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 207 Query: 143 KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEM 202 K +L+L D+GLA + + + ++ V + +++ P++L+ R Y S+D+WS G +LA M Sbjct: 208 KNKKLRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 266 Query: 203 IT-GKPLFPGTNDEEQLKLIFDIMGT--PNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQ 259 I +P F GT++ +QL I ++GT + L LP+ ++ Q + + + Sbjct: 267 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 326 Query: 260 PHTKEPL-DGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 K + ++D + LL+ + RL+AK+A+ HPWFA Sbjct: 327 DGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 366 >4LRM-A nrPDB Length = 334 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 55/240 (22%), Positives = 109/240 (45%), Gaps = 18/240 (7%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYV----ALKEVKLDSEEGTPSTAIREISLMKEL 60 ++FK+++ LG+G + TVYKGL G V A+KE++ + + E +M + Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 78 Query: 61 KHE---NIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 + ++ RL + T + L+ + M L Y+ + L + Q Sbjct: 79 DNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYL-----LNWCVQ 132 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV--TLWY 174 + +G+ + + +++HRDL +N+L+ +K+ DFGLA+ G + +E + + Sbjct: 133 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 192 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 A + ++ R Y+ D+WS G + E++T G + G E ++ P + Sbjct: 193 MALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPIC 251 >3AOX-A nrPDB Length = 344 Score = 194 bits (493), Expect = 4e-50, Method: Composition-based stats. Identities = 55/243 (22%), Positives = 99/243 (40%), Gaps = 14/243 (5%) Query: 6 QFKQLEKLGNGTYATVYKGL-----NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 + LG+G + VY+G N + + VA+K + E + E ++ + Sbjct: 48 NITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKF 107 Query: 61 KHENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDS-RTVGNTPRGLELNLVKYFQWQLL 118 H+NIVR V ++ E M DLK ++ R + P L + + + + Sbjct: 108 NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIA 167 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRG---QLKLGDFGLARAFGIPVNTFSSEVV--TLW 173 G + EN +HRD+ +N L+ G K+GDFG+AR + Sbjct: 168 CGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVK 227 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESL 232 + P+ M +++ D WS G +L E+ + G +P +++E L+ + Sbjct: 228 WMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKN 286 Query: 233 WPS 235 P Sbjct: 287 CPG 289 >3ORP-A nrPDB Length = 311 Score = 193 bits (492), Expect = 6e-50, Method: Composition-based stats. Identities = 62/246 (25%), Positives = 105/246 (42%), Gaps = 17/246 (6%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKE 59 S +++ E LG G + V+ + VA+K ++ D + RE Sbjct: 9 HLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAA 68 Query: 60 LKHENIVRLYDVIHTENKL----TLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQ 114 L H IV +YD E +V E++D L+ + + R +E Sbjct: 69 LNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIE------VI 122 Query: 115 WQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE---VVT 171 Q L F H+N I+HRD+KP N++I+ +K+ DFG+ARA N+ + + T Sbjct: 123 ADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGT 182 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 Y +P+ G + D++S GC+L E++TG+P F G + P + Sbjct: 183 AQYLSPEQARGD-SVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSA 241 Query: 232 LWPSVT 237 ++ Sbjct: 242 RHEGLS 247 >6CTH-A nrPDB Length = 309 Score = 193 bits (491), Expect = 8e-50, Method: Composition-based stats. Identities = 61/208 (29%), Positives = 102/208 (49%), Gaps = 12/208 (5%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 +S F KLG G + +VY+G + + Y+A+K+V S++G A E+ ++ L+H+ Sbjct: 14 TSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYA-SEVKIISRLRHK 72 Query: 64 NIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 N+V+L H +L LV+EFM + L ++ L + L L Sbjct: 73 NLVKLIGWCHERGELMLVYEFMANGSLDSHI-----FKGKSLLTWEVRYRIVKDLASALL 127 Query: 123 FCHENK---ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSS-EVVTLWYRAPD 178 + HE +LHRD+K N++++ KLGDFGLAR + T+ Y AP+ Sbjct: 128 YLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPE 187 Query: 179 VLMGSRTYSTSIDIWSCGCILAEMITGK 206 L + S D++S G + E+ +G+ Sbjct: 188 CLSSGKA-SKESDVYSFGVVALEIASGR 214 >3ZZW-A nrPDB Length = 289 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 60/271 (22%), Positives = 119/271 (43%), Gaps = 23/271 (8%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLN-----KTTGVYVALKEVKLDSEEGTPSTAIREISLM 57 S S + +E+LG + VYKG VA+K +K +E E L Sbjct: 7 SLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLR 66 Query: 58 KELKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNT----------PRGLE 106 L+H N+V L V+ + L+++F + DL +++ R+ + LE Sbjct: 67 ARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALE 126 Query: 107 LNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT-- 164 + Q+ G+ + + ++H+DL +N+L+ + +K+ D GL R Sbjct: 127 PPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKL 186 Query: 165 FSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFD 223 + ++ + + AP+ +M + +S DIWS G +L E+ + G + G ++++ +++I + Sbjct: 187 LGNSLLPIRWMAPEAIMYGK-FSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRN 245 Query: 224 IMGTPNESLWPS---VTKLPKYNPNIQQRPP 251 P P+ + +N +RP Sbjct: 246 RQVLPCPDDCPAWVYALMIECWNEFPSRRPR 276 >2W1I-A nrPDB Length = 326 Score = 193 bits (490), Expect = 9e-50, Method: Composition-based stats. Identities = 63/296 (21%), Positives = 123/296 (41%), Gaps = 34/296 (11%) Query: 6 QFKQLEKLGNGTYATVYKGLNK----TTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 K L++LG G + +V TG VA+K+++ +EE REI ++K L+ Sbjct: 42 HLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLR-DFEREIEILKSLQ 100 Query: 62 HENIVRLYDVIHTENK--LTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 H+NIV+ V ++ + L L+ E++ L+ Y+ ++ + + Q+ Sbjct: 101 HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK-----ERIDHIKLLQYTSQIC 155 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV---TLWYR 175 +G+ + + +HRDL +N+L+ ++K+GDFGL + + + +++ Sbjct: 156 KGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY 215 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 AP+ L S+ +S + D+WS G +L E+ T I P E + Sbjct: 216 APESLTESK-FSVASDVWSFGVVLYELFT---------------YIEKSKSPPAE--FMR 257 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 + K I L+ + + + + N + R S + Sbjct: 258 MIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 313 >3IO7-A nrPDB Length = 313 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 63/296 (21%), Positives = 123/296 (41%), Gaps = 34/296 (11%) Query: 6 QFKQLEKLGNGTYATVYKGLNK----TTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 K L++LG G + +V TG VA+K+++ +EE REI ++K L+ Sbjct: 29 HLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLR-DFEREIEILKSLQ 87 Query: 62 HENIVRLYDVIHTENK--LTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 H+NIV+ V ++ + L L+ E++ L+ Y+ ++ + + Q+ Sbjct: 88 HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK-----ERIDHIKLLQYTSQIC 142 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV---TLWYR 175 +G+ + + +HRDL +N+L+ ++K+GDFGL + + + +++ Sbjct: 143 KGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY 202 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 AP+ L S+ +S + D+WS G +L E+ T I P E + Sbjct: 203 APESLTESK-FSVASDVWSFGVVLYELFT---------------YIEKSKSPPAE--FMR 244 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 + K I L+ + + + + N + R S + Sbjct: 245 MIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >4HVI-A nrPDB Length = 314 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 59/292 (20%), Positives = 120/292 (41%), Gaps = 35/292 (11%) Query: 6 QFKQLEKLGNGTYATVYKGLNK----TTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 K + +LG G + +V TG VA+K+++ S REI ++K L Sbjct: 11 HLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH-SGPDQQRDFQREIQILKALH 69 Query: 62 HENIVRLYDVIHTENK--LTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 + IV+ V + + L LV E++ + L+ ++ L+ + + + Q+ Sbjct: 70 SDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRA-----RLDASRLLLYSSQIC 124 Query: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV---TLWYR 175 +G+ + + +HRDL +N+L+ +K+ DFGLA+ + + + +++ Sbjct: 125 KGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWY 184 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 AP+ L + +S D+WS G +L E+ T D+ + +E P+ Sbjct: 185 APESLSDN-IFSRQSDVWSFGVVLYELFT-------YCDKSCSPSAEFLRMMGSERDVPA 236 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 +++L + Q+ P + + + +P R S Sbjct: 237 LSRLLELLEEGQRLP-----------APPACPAEVHELMKLCWAPSPQDRPS 277 >5TQX-A nrPDB Length = 655 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 72/303 (23%), Positives = 128/303 (42%), Gaps = 34/303 (11%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E+LG G + V ++ + +A+K +L+ EI +MK+L H N+V+ D Sbjct: 14 ERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACD 73 Query: 71 VIHTENKLT-----LVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 V N L L E+ DL+K ++ GL+ + + + G+ + Sbjct: 74 VPEELNILIHDVPLLAMEYCSGGDLRKLLNK---PENCCGLKESQILSLLSDIGSGIRYL 130 Query: 125 HENKILHRDLKPQNLLI-NKRGQL--KLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 HENKI+HRDLKP+N+++ + G++ K+ D G A+ + V TL Y AP+ L Sbjct: 131 HENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQ-GELCTEFVGTLQYLAPE-LF 188 Query: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 ++ Y+ ++D WS G ++ E I G F ++ + Sbjct: 189 ENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVR 248 Query: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMR-----LSAKQ-----A 291 ++ ++ Q P +++P L +L +P R L+ KQ Sbjct: 249 FSSHLPQ-PNSLCSLIVEPMENW---------LQLMLNWDPQQRGGPVDLTLKQPRCFVL 298 Query: 292 LHH 294 + H Sbjct: 299 MDH 301 >4YFF-A nrPDB Length = 311 Score = 191 bits (485), Expect = 3e-49, Method: Composition-based stats. Identities = 47/212 (22%), Positives = 97/212 (45%), Gaps = 14/212 (6%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS--EEGTPSTAIREISLMKELKH 62 S+ + E +G+G++ VYKG + VA+K + ++ + RE+S++ +L H Sbjct: 42 SEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNH 99 Query: 63 ENIVRLYDVIH-TENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 +++ ++ +V +++ L + + R L+L + +G Sbjct: 100 PCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-----RILDLQSKLIIAVDVAKG 154 Query: 121 LAFCHE--NKILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWYRAP 177 + + H I+HRDL N+L+ + G + DFG +R + + + + L + AP Sbjct: 155 MEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAP 214 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLF 209 +V Y+ D++S L E++TG+ F Sbjct: 215 EVFTQCTRYTIKADVFSYALCLWEILTGEIPF 246 >3LLT-A nrPDB Length = 360 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 75/340 (22%), Positives = 141/340 (41%), Gaps = 52/340 (15%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 M ++ F + K+G+GT+ V + Y A+K V+ + + +A E ++K++ Sbjct: 31 MLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVR--NIKKYTRSAKIEADILKKI 88 Query: 61 KHENI-----VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 ++++I V+ + + + L+FE + L + + N G + +K + Sbjct: 89 QNDDINNNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITR----NNYNGFHIEDIKLYCI 144 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQ-------------------------LKLG 150 ++L+ L + + + H DLKP+N+L++ +KL Sbjct: 145 EILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLI 204 Query: 151 DFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFP 210 DFG A + S + T YRAP+V++ + S D+WS GC+LAE+ TG LF Sbjct: 205 DFGCA---TFKSDYHGSIINTRQYRAPEVILN-LGWDVSSDMWSFGCVLAELYTGSLLFR 260 Query: 211 GTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQ----------- 259 E L ++ I+ +++ TK + + Sbjct: 261 THEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKC 320 Query: 260 -PHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 P K DFL+ +LQ++P +R S + L H + Sbjct: 321 LPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >3PLS-A nrPDB Length = 298 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 61/272 (22%), Positives = 110/272 (40%), Gaps = 16/272 (5%) Query: 11 EKLGNGTYATVYKGLNKT---TGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVR 67 +G G + VY G + A+K + +E +RE LM+ L H N++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLA 86 Query: 68 LYDVIHTENKL-TLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 L ++ L ++ +M DL +++ S T + L F Q+ +G+ + Sbjct: 87 LIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDL-----ISFGLQVARGMEYLA 141 Query: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAF----GIPVNTFSSEVVTLWYRAPDVLM 181 E K +HRDL +N ++++ +K+ DFGLAR V + + + A + L Sbjct: 142 EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQ 201 Query: 182 GSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 R ++T D+WS G +L E++T G P + + + + P P Sbjct: 202 TYR-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQV 260 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMD 272 R +VL ++ + L D Sbjct: 261 MQQCWEADPAVRPTFRVLVGEVEQIVSALLGD 292 >5TUR-A nrPDB Length = 404 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 124/305 (40%), Gaps = 58/305 (19%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPS-----TAIREISLMKE 59 SQ++ LG+G + +VY G+ + + VA+K V+ D E+ L+K+ Sbjct: 127 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 186 Query: 60 LKH--ENIVRLYDVIHTENKLTLVFEFMD--NDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 + ++RL D + L+ E + DL ++ R L+ L + F W Sbjct: 187 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG------ALQEELARSFFW 240 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 Q+L+ + CH +LHRD+K +N+LI+ RG+LKL DFG ++ T Y Sbjct: 241 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVY 298 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 P+ + R + S +WS G +L +M+ G F +DEE ++ Sbjct: 299 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEIIR--------------- 341 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 Q ++ + + L L P R + ++ +H Sbjct: 342 -----------------------GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 378 Query: 295 PWFAE 299 PW + Sbjct: 379 PWMQD 383 >6J5U-C nrPDB Length = 426 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 70/305 (22%), Positives = 125/305 (40%), Gaps = 36/305 (11%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTT---------GVYVALKEVKLDSEEGTPSTAIR 52 +++ F+Q LG G + V+KG T G+ VA+K++K + +G + Sbjct: 81 NATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQG-HKEWLT 139 Query: 53 EISLMKELKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVK 111 E++ + +L H N+V L LV+EFM L+ ++ R + L + Sbjct: 140 EVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGA----QPLTWAIRM 195 Query: 112 YFQWQLLQGLAFCHENK--ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SS 167 +GL F HE K +++RD K N+L++ KL DFGLA+A NT + Sbjct: 196 KVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTK 255 Query: 168 EVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGT 227 + T Y AP+ + R + D++S G +L E+I+G+ +N + L+ Sbjct: 256 VIGTHGYAAPEYVATGR-LTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLV------ 308 Query: 228 PNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 + P + K + + L + + L + +R Sbjct: 309 --DWATPYLGDKRKLFRIMDTK--------LGGQYPQKGAFTAANLALQCLNPDAKLRPK 358 Query: 288 AKQAL 292 + L Sbjct: 359 MSEVL 363 >5LPZ-A nrPDB Length = 332 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 59/214 (27%), Positives = 102/214 (47%), Gaps = 11/214 (5%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 + +++ F +G+G + VYK + K G VA+K++ S +G + E+ + ++ Sbjct: 13 LQATNGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDRE-FMAEMETIGKI 70 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 KH N+V L ++ LV+EFM L+ + L + + + Sbjct: 71 KHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVL--HDPKKAGVKLNWSTRRKIAIGSAR 128 Query: 120 GLAFCHEN---KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVTLWY 174 GLAF H N I+HRD+K N+L+++ + ++ DFG+AR S+ T Y Sbjct: 129 GLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGY 188 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPL 208 P+ R ST D++S G +L E++TGK Sbjct: 189 VPPEYYQSFRC-STKGDVYSYGVVLLELLTGKRP 221 >5LPV-A nrPDB Length = 296 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 59/214 (27%), Positives = 102/214 (47%), Gaps = 11/214 (5%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 + +++ F +G+G + VYK + K G VA+K++ S +G + E+ + ++ Sbjct: 13 LQATNGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDRE-FMAEMETIGKI 70 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 KH N+V L ++ LV+EFM L+ + L + + + Sbjct: 71 KHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVL--HDPKKAGVKLNWSTRRKIAIGSAR 128 Query: 120 GLAFCHEN---KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--SSEVVTLWY 174 GLAF H N I+HRD+K N+L+++ + ++ DFG+AR S+ T Y Sbjct: 129 GLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGY 188 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPL 208 P+ R ST D++S G +L E++TGK Sbjct: 189 VPPEYYQSFRC-STKGDVYSYGVVLLELLTGKRP 221 >3BGP-A nrPDB Length = 333 Score = 187 bits (476), Expect = 4e-48, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 124/305 (40%), Gaps = 58/305 (19%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPS-----TAIREISLMKE 59 SQ++ LG+G + +VY G+ + + VA+K V+ D E+ L+K+ Sbjct: 56 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 115 Query: 60 LKH--ENIVRLYDVIHTENKLTLVFEFMD--NDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 + ++RL D + L+ E + DL ++ R L+ L + F W Sbjct: 116 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG------ALQEELARSFFW 169 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 Q+L+ + CH +LHRD+K +N+LI+ RG+LKL DFG ++ T Y Sbjct: 170 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVY 227 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 P+ + R + S +WS G +L +M+ G F +DEE ++ Sbjct: 228 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEIIR--------------- 270 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 Q ++ + + L L P R + ++ +H Sbjct: 271 -----------------------GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 307 Query: 295 PWFAE 299 PW + Sbjct: 308 PWMQD 312 >5HVK-A nrPDB Length = 315 Score = 187 bits (476), Expect = 4e-48, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 118/310 (38%), Gaps = 53/310 (17%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 S E LG G + K ++ TG + +KE+ + +E T T ++E+ +M+ L+H Sbjct: 12 RPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKEL-IRFDEETQRTFLKEVKVMRCLEH 70 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 N+++ V++ + +L + E++ + + P ++ F + G+A Sbjct: 71 PNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVS----FAKDIASGMA 126 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF--------------GIPVNTFSSE 168 + H I+HR+L N L+ + + + DFGLAR + Sbjct: 127 YLHSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTV 186 Query: 169 VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTP 228 V ++ AP+++ G R+Y +D++S G +L E+ I + P Sbjct: 187 VGNPYWMAPEMING-RSYDEKVDVFSFGIVLCEI------------------IGRVNADP 227 Query: 229 NESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA 288 + P R P + P+ D +P+ R S Sbjct: 228 D--YLPRTMDFGLNVRGFLDRYCPP----NCPPSFFPITVRCCDL-------DPEKRPSF 274 Query: 289 KQALHHPWFA 298 + L H W Sbjct: 275 VK-LEH-WLE 282 >5VD3-A nrPDB Length = 311 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 69/295 (23%), Positives = 114/295 (38%), Gaps = 45/295 (15%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKE-VKLDSEEGTPSTAIREISLMKEL-KHEN 64 F++L +LG+G+Y V+K +K G A+K + + + E+ +++ +H Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 118 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 VRL L L E L+++ ++ L V + L LA Sbjct: 119 CVRLEQAWEEGGILYLQTELCGPSLQQHCEA-----WGASLPEAQVWGYLRDTLLALAHL 173 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 H ++H D+KP N+ + RG+ KLGDFGL G + Y AP++L GS Sbjct: 174 HSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAG-EVQEGDPRYMAPELLQGS- 231 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 Y T+ D++S G + E+ L G +QL+ Sbjct: 232 -YGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ------------------------ 266 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 L P L L L +L+ +P +R +A+ L P + Sbjct: 267 -----------GYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ 310 >5O0Y-A nrPDB Length = 579 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 117/310 (37%), Gaps = 57/310 (18%) Query: 18 YATVYKGLNKTTGVYVALKEVKL------DSEEGTPSTAIREISLMKELKHENIVRLYDV 71 ++ VYK + T YVA+K +L + +E A RE + KEL H IV+LYD Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 72 I-HTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK- 128 + V E+ + DL Y+ + + + Q++ L + +E K Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKL------MSEKEARSIIMQIVNALKYLNEIKP 410 Query: 129 -ILHRDLKPQNLLI---NKRGQLKLGDFGLARAFGIP-------VNTFSSEVVTLWYRAP 177 I+H DLKP N+L+ G++K+ DFGL++ + S T WY P Sbjct: 411 PIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPP 470 Query: 178 DVL---MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 + S +D+WS G I + + G+ F G N +Q Sbjct: 471 ECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQ----------------D 513 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 + + Q PP+ + + F+ L + R+ +Q Sbjct: 514 ILQENTILKATEVQFPPKPV-----------VTPEAKAFIRRCLAYRKEDRIDVQQLACD 562 Query: 295 PWFAEYYHHA 304 P+ + + Sbjct: 563 PYLLPHIRKS 572 >4RC3-A nrPDB Length = 289 Score = 187 bits (474), Expect = 7e-48, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 124/305 (40%), Gaps = 58/305 (19%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPS-----TAIREISLMKE 59 SQ++ LG+G + +VY G+ + + VA+K V+ D E+ L+K+ Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 71 Query: 60 LKH--ENIVRLYDVIHTENKLTLVFEFMD--NDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 + ++RL D + L+ E + DL ++ R L+ L + F W Sbjct: 72 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG------ALQEELARSFFW 125 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWY 174 Q+L+ + CH +LHRD+K +N+LI+ RG+LKL DFG ++ T Y Sbjct: 126 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVY 183 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 P+ + R + S +WS G +L +M+ G F +DEE ++ Sbjct: 184 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEIIR--------------- 226 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHH 294 Q ++ + + L L P R + ++ +H Sbjct: 227 -----------------------GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 263 Query: 295 PWFAE 299 PW + Sbjct: 264 PWMQD 268 >3UIM-A nrPDB Length = 326 Score = 186 bits (473), Expect = 9e-48, Method: Composition-based stats. Identities = 66/286 (23%), Positives = 129/286 (45%), Gaps = 11/286 (3%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 +S F LG G + VYKG G VA+K +K + +G E+ ++ H Sbjct: 28 ASDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVH 86 Query: 63 ENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 N++RL T + LV+ +M + + + R P L+ + +GL Sbjct: 87 RNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPP--LDWPKRQRIALGSARGL 144 Query: 122 AFCHEN---KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV-VTLWYRAP 177 A+ H++ KI+HRD+K N+L+++ + +GDFGLA+ ++ V T+ + AP Sbjct: 145 AYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAP 204 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTN--DEEQLKLIFDIMGTPNESLWPS 235 + L ++ S D++ G +L E+ITG+ F +++ + L+ + G E + Sbjct: 205 EYLSTGKS-SEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKLEA 263 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLN 281 + + + + ++ L P++ M + +L+ + Sbjct: 264 LVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVVRMLEGD 309 >4F0G-A nrPDB Length = 287 Score = 186 bits (473), Expect = 9e-48, Method: Composition-based stats. Identities = 64/299 (21%), Positives = 120/299 (40%), Gaps = 55/299 (18%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPS------TAIREISL 56 + ++ + +++G G + V+KG VA+K + L EG RE+ + Sbjct: 17 ADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFI 76 Query: 57 MKELKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 M L H NIV+LY ++H + +V EF+ DL + + ++ ++ Sbjct: 77 MSNLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLY-----HRLLDKAHPIKWSVKLRLML 129 Query: 116 QLLQGLAFCHENK--ILHRDLKPQNLL---INKRGQL--KLGDFGLARAFGIPVNTFSSE 168 + G+ + I+HRDL+ N+ +++ + K+ DFGL++ V++ S Sbjct: 130 DIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ---SVHSVSGL 186 Query: 169 VVTLWYRAPDVL-MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGT 227 + + AP+ + +Y+ D +S IL ++TG+ F DE I I Sbjct: 187 LGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPF----DEYSYGKIKFINMI 242 Query: 228 PNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL 286 E L P++ + PPR L + + +P R Sbjct: 243 REEGLRPTIPE---------DCPPR-----------------LRNVIELCWSGDPKKRP 275 >5WNO-A nrPDB Length = 330 Score = 185 bits (471), Expect = 1e-47, Method: Composition-based stats. Identities = 54/272 (19%), Positives = 116/272 (42%), Gaps = 17/272 (6%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLN-----KTTGVYVALKEVKLDSEEGTPSTAIREISL 56 SS Q K +KLG G + TV+ G+ K + VA+K + D + + E + Sbjct: 19 SSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTD--EMLEEATN 76 Query: 57 MKELKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 M L+H+N++++ ++ L +V + +L+ ++ R L + + Sbjct: 77 MFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVL-----YCY 131 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV--TLW 173 Q+ G+ + + +++HRDL +N+L+ K +++ DFGL++ ++ + + + Sbjct: 132 QIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIK 191 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESL 232 + A + + Y+ + D+W+ G E+IT G+ + G + + + D Sbjct: 192 WLAIE-IFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPN 250 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKE 264 + R ++L KE Sbjct: 251 CSQDLYQELLRCWMADPKSRPGFEILYERFKE 282 >3M42-A nrPDB Length = 299 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 103/304 (33%), Gaps = 67/304 (22%) Query: 5 SQFKQ-LEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLM-KELKH 62 +K + LG G V + NK T ALK + A RE+ L + + Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQC 70 Query: 63 ENIVRLYDVIHT----ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 +IVR+ DV L +V E +D + SR + + Sbjct: 71 PHIVRIVDVYENLYAGRKCLLIVMECLDGG---ELFSRIQDRGDQAFTEREASEIMKSIG 127 Query: 119 QGLAFCHENKILHRDLKPQNLLINK---RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYR 175 + + + H I HRD+KP+NLL LKL DFG A+ Sbjct: 128 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT---------------- 171 Query: 176 APDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPS 235 Y S D+WS G I+ ++ G P F + Sbjct: 172 -------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAI------------------ 206 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 +P ++ R + P E + + + LL+ P R++ + ++HP Sbjct: 207 -------SPGMKTRIRMGQYEFPNPEWSE-VSEEVKMLIRNLLKTEPTQRMTITEFMNHP 258 Query: 296 WFAE 299 W + Sbjct: 259 WIMQ 262 >4NEU-A nrPDB Length = 333 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 62/300 (20%), Positives = 119/300 (39%), Gaps = 52/300 (17%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKH 62 SS F + +L +G + V ++T G+ + +K V K + + E +M L+H Sbjct: 23 SSDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRH 81 Query: 63 ENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 +V+L VI E K +LV E+M+ +L + + L++ ++++G+ Sbjct: 82 SRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEM------STPLSVKGRIILEIIEGM 135 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLAR-------------AFGIPVNTFSSE 168 + H ++H+DLKP+N+L++ +K+ D GLA T Sbjct: 136 CYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKN 195 Query: 169 VVTLWYRAPDVLMG-SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGT 227 TL+Y AP+ L + + D++S +L + K + E+QL + Sbjct: 196 GGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQL------IMC 249 Query: 228 PNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 P V + +Y P ++ + + NP+ R + Sbjct: 250 IKSGNRPDVDDITEYCP-----------------------REIISLMKLCWEANPEARPT 286 >4X7Q-B nrPDB Length = 312 Score = 183 bits (465), Expect = 7e-47, Method: Composition-based stats. Identities = 64/305 (20%), Positives = 113/305 (37%), Gaps = 60/305 (19%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD-----SEEGTPSTAIREISLMKEL 60 +++ LG G + TV+ G T + VA+K + + S T E++L+ ++ Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 61 K----HENIVRLYDVIHTENKLTLVFE--FMDNDLKKYMDSRTVGNTPRGLELNLVKYFQ 114 H ++RL D T+ LV E DL Y+ + + F Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPS------RCFF 145 Query: 115 WQLLQGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLW 173 Q++ + CH ++HRD+K +N+LI+ +RG KL DFG ++ T Sbjct: 146 GQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLH--DEPYTDFDGTRV 203 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 Y P+ + + ++ +WS G +L +M+ G F D+E L+ Sbjct: 204 YSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF--ERDQEILE-------------- 247 Query: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 + H + + + L P R S ++ L Sbjct: 248 ------------------------AELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILL 283 Query: 294 HPWFA 298 PW Sbjct: 284 DPWMQ 288 >4C59-A nrPDB Length = 340 Score = 182 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 122/313 (38%), Gaps = 65/313 (20%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HEN 64 + + L G +A VY+ + +G ALK + L +EE I+E+ MK+L H N Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRL-LSNEEEKNRAIIQEVCFMKKLSGHPN 86 Query: 65 IVRL-----YDVIHTEN---KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 IV+ ++ + L+ E L +++ L + V +Q Sbjct: 87 IVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGP---LSCDTVLKIFYQ 143 Query: 117 LLQGLAFCHENK--ILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEV---- 169 + + H K I+HRDLK +NLL++ +G +KL DFG A P ++S++ Sbjct: 144 TCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALV 203 Query: 170 -------VTLWYRAPDVL--MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKL 220 T YR P+++ + DIW+ GCIL + + F D +L++ Sbjct: 204 EEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFE---DGAKLRI 260 Query: 221 IFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQL 280 + P +V + +LQ+ Sbjct: 261 VNGKYSIPPHDTQYTV---------------------------------FHSLIRAMLQV 287 Query: 281 NPDMRLSAKQALH 293 NP+ RLS + +H Sbjct: 288 NPEERLSIAEVVH 300 >4TPT-A nrPDB Length = 303 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 56/215 (26%), Positives = 98/215 (45%), Gaps = 29/215 (13%) Query: 10 LEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 E LG G + K +K TG + +KE+ + +E T T + E+ +M+ L H N+++ Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKEL-IRCDEETQKTFLTEVKVMRSLDHPNVLKFI 63 Query: 70 DVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 V++ + KL L+ E+++ LK ++ S F + G+A+ H Sbjct: 64 GVLYKDKKLNLLTEYIEGGTLKDFLRSMDP------FPWQQKVRFAKGIASGMAYLHSMC 117 Query: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAF--------------------GIPVNTFSSE 168 I+HRDL N LI + + DFGL+R + Sbjct: 118 IIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTV 177 Query: 169 VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMI 203 V ++ AP++L G ++Y ++DI+S G +L E+I Sbjct: 178 VGNPYWMAPEMLNG-KSYDETVDIFSFGIVLCEII 211 >4JLC-A nrPDB Length = 657 Score = 181 bits (459), Expect = 4e-46, Method: Composition-based stats. Identities = 72/290 (24%), Positives = 111/290 (38%), Gaps = 25/290 (8%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 + LG G A V++G +K TG A+K S +RE ++K+L H+NIV+L+ Sbjct: 14 DILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 73 Query: 71 VIHTEN--KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 + L+ EF L ++ + GL + ++ G+ EN Sbjct: 74 IEEETTTRHKVLIMEFCPCGSLYTVLEE---PSNAYGLPESEFLIVLRDVVGGMNHLREN 130 Query: 128 KILHRDLKPQNLL--INKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG- 182 I+HRD+KP N++ I + GQ KL DFG AR F S T Y PD+ Sbjct: 131 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERA 189 Query: 183 ------SRTYSTSIDIWSCGCILAEMITGKPLF-PGTNDEEQLKLIFDIMGTPNESLWPS 235 + Y ++D+WS G TG F P ++++ I+ Sbjct: 190 VLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISG 249 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFL----HGLLQLN 281 V K N I L L + L L + L + Sbjct: 250 VQKAE--NGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFD 297 >4EUU-A nrPDB Length = 319 Score = 181 bits (459), Expect = 4e-46, Method: Composition-based stats. Identities = 68/250 (27%), Positives = 108/250 (43%), Gaps = 25/250 (10%) Query: 2 SSSSQFKQL-EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 S+S+ L + LG G A V++G +K TG A+K S +RE ++K+L Sbjct: 5 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 64 Query: 61 KHENIVRLYDVIHTEN--KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 H+NIV+L+ + L+ EF L ++ + GL + + Sbjct: 65 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEE---PSNAYGLPESEFLIVLRDV 121 Query: 118 LQGLAFCHENKILHRDLKPQNLL--INKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLW 173 + G+ EN I+HR++KP N++ I + GQ KL DFG AR F S T Sbjct: 122 VGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEE 180 Query: 174 YRAPDVLMG-------SRTYSTSIDIWSCGCILAEMITGKPLFP----GTNDEEQLKLIF 222 Y PD+ + Y ++D+WS G TG F ++E + I Sbjct: 181 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI- 239 Query: 223 DIMGTPNESL 232 I G P+ ++ Sbjct: 240 -ITGKPSGAI 248 >2RIO-A nrPDB Length = 434 Score = 180 bits (457), Expect = 6e-46, Method: Composition-based stats. Identities = 76/314 (24%), Positives = 134/314 (42%), Gaps = 62/314 (19%) Query: 11 EKLGNGTYATV-YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HENIVRL 68 + LG G+ TV ++G + G VA+K + +D + A+ EI L+ E H N++R Sbjct: 21 KILGYGSSGTVVFQGSFQ--GRPVAVKRMLIDFCDI----ALMEIKLLTESDDHPNVIRY 74 Query: 69 YDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLV-KYFQWQLLQGLAFCHEN 127 Y T+ L + E + +L+ ++S+ V + L+ Q+ G+A H Sbjct: 75 YCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSL 134 Query: 128 KILHRDLKPQNLLIN-------------KRGQLKLGDFGLARAFGIPVNTFSSEV----V 170 KI+HRDLKPQN+L++ + ++ + DFGL + ++F + + Sbjct: 135 KIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSG 194 Query: 171 TLWYRAPDVLMGS------RTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFD 223 T +RAP++L S R + SIDI+S GC+ +++ GK F E I Sbjct: 195 TSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRE--SNIIR 252 Query: 224 IMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPD 283 + + +E ++ L D + ++ +P Sbjct: 253 GIFSLDE---------------------------MKCLHDRSLIAEATDLISQMIDHDPL 285 Query: 284 MRLSAKQALHHPWF 297 R +A + L HP F Sbjct: 286 KRPTAMKVLRHPLF 299 >5WNL-A nrPDB Length = 342 Score = 180 bits (456), Expect = 9e-46, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 121/297 (40%), Gaps = 43/297 (14%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVK-LDSEEGTPSTAIREISLMKELK 61 + +F EK+G+G + VYK + ++A+K L ++ + E M+ K Sbjct: 18 DAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAK 77 Query: 62 HENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 I+ +Y + + LV E+M+ L+K + S L +L + G Sbjct: 78 FRYILPVYGICQE--PVGLVMEYMETGSLEKLLAS-------EPLPWDLRFRIVHETAVG 128 Query: 121 LAFCH--ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN---TFSSEVVTLWYR 175 + F H +LH +LKP N+L++ +K+ DFGLA+ G+ + + T+ Y Sbjct: 129 MNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYL 188 Query: 176 APDVL-MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 P+ + SR + T D++S ++ ++T K F +++ L ++ ++ L P Sbjct: 189 PPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPF--ADEKNILHIMMKVVKGHRPELPP 246 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 P+ +L+ + +P +R + ++ Sbjct: 247 ICRPRPRAC------------------------ASLIGLMQRCWHADPQVRPTFQEI 279 >3Q4U-A nrPDB Length = 301 Score = 180 bits (456), Expect = 9e-46, Method: Composition-based stats. Identities = 77/319 (24%), Positives = 111/319 (34%), Gaps = 69/319 (21%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMK--ELK 61 + LE +G G Y V++G + G VA+K E+ RE L L+ Sbjct: 7 ARDITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKS----WFRETELYNTVMLR 60 Query: 62 HENIVRLYDVIHTENK----LTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 HENI+ T L L+ + + L Y+ T L+ Sbjct: 61 HENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTT-------LDTVSCLRIVLS 113 Query: 117 LLQGLAFCH--------ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--- 165 + GLA H + I HRDLK +N+L+ K GQ + D GLA N Sbjct: 114 IASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVG 173 Query: 166 -SSEVVTLWYRAPDVLMGSRTYS-----TSIDIWSCGCILAEMITG----------KPLF 209 + V T Y AP+VL + +DIW+ G +L E+ KP F Sbjct: 174 NNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPF 233 Query: 210 PGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGN 269 + PS + K QQRP + +P + Sbjct: 234 YDVVPND-----------------PSFEDMRKVVCVDQQRP-----NIPNRWFSDPTLTS 271 Query: 270 LMDFLHGLLQLNPDMRLSA 288 L + NP RL+A Sbjct: 272 LAKLMKECWYQNPSARLTA 290 >2A1A-B nrPDB Length = 284 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 119/305 (39%), Gaps = 66/305 (21%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 FK++E +G+G + V+K ++ G +K VK ++E+ RE+ + +L H NI Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAE-----REVKALAKLDHVNI 66 Query: 66 VRLYDVI----------------HTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELN 108 V L + EF D L+++++ R L+ Sbjct: 67 VHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRR----GEKLDKV 122 Query: 109 LVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE 168 L Q+ +G+ + H K+++RDLKP N+ + Q+K+GDFGL + S+ Sbjct: 123 LALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSK 182 Query: 169 VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTP 228 TL Y +P+ + S+ Y +D+++ G ILAE++ Sbjct: 183 -GTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL------------------------- 215 Query: 229 NESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA 288 + + + K+ + + D L LL P+ R + Sbjct: 216 --HVCDTAFETSKF-----------FTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNT 262 Query: 289 KQALH 293 + L Sbjct: 263 SEILR 267 >4EUT-A nrPDB Length = 396 Score = 179 bits (454), Expect = 1e-45, Method: Composition-based stats. Identities = 68/250 (27%), Positives = 108/250 (43%), Gaps = 25/250 (10%) Query: 2 SSSSQFKQL-EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 S+S+ L + LG G A V++G +K TG A+K S +RE ++K+L Sbjct: 5 STSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL 64 Query: 61 KHENIVRLYDVIHTEN--KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 H+NIV+L+ + L+ EF L ++ + GL + + Sbjct: 65 NHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEE---PSNAYGLPESEFLIVLRDV 121 Query: 118 LQGLAFCHENKILHRDLKPQNLL--INKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLW 173 + G+ EN I+HR++KP N++ I + GQ KL DFG AR F S T Sbjct: 122 VGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEE 180 Query: 174 YRAPDVLMG-------SRTYSTSIDIWSCGCILAEMITGKPLFP----GTNDEEQLKLIF 222 Y PD+ + Y ++D+WS G TG F ++E + I Sbjct: 181 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI- 239 Query: 223 DIMGTPNESL 232 I G P+ ++ Sbjct: 240 -ITGKPSGAI 248 >2PMN-X nrPDB Length = 348 Score = 179 bits (454), Expect = 1e-45, Method: Composition-based stats. Identities = 62/316 (19%), Positives = 118/316 (37%), Gaps = 39/316 (12%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPS---------------- 48 + ++ + L G + + + ALK+ + E Sbjct: 31 NDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYD 88 Query: 49 TAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTV---GNTPRGL 105 E+ ++ ++K+E + +I +++ +++E+M+ND D N + Sbjct: 89 DFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFI 148 Query: 106 ELNLVKYFQWQLLQGLAFCH-ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT 164 + ++K +L ++ H E I HRD+KP N+L++K G++KL DFG + Sbjct: 149 PIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMV--DKK 206 Query: 165 FSSEVVTLWYRAPDVLMGSRTY-STSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFD 223 T + P+ +Y +DIWS G L M F Sbjct: 207 IKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFS------------- 253 Query: 224 IMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPD 283 + L+ ++ P + L + L +DFL L+ NP Sbjct: 254 -LKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPA 312 Query: 284 MRLSAKQALHHPWFAE 299 R++++ AL H W A+ Sbjct: 313 ERITSEDALKHEWLAD 328 >4PL5-B nrPDB Length = 435 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 76/300 (25%), Positives = 132/300 (44%), Gaps = 55/300 (18%) Query: 11 EKLGNGTYAT-VYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HENIVRL 68 + LG+G T VYKG+ VA+K + + S A RE+ L++E H N++R Sbjct: 33 DVLGHGAEGTIVYKGMF--DNRDVAVKRILPECF----SFADREVQLLRESDEHPNVIRY 86 Query: 69 YDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 + + E L++Y++ + + GLE + + Q GLA H Sbjct: 87 FCTEKDRQFQYIAIELCAATLQEYVEQKDFAHL--GLEPITLLH---QTTSGLAHLHSLN 141 Query: 129 ILHRDLKPQNLLI---NKRGQLK--LGDFGLARAFGIPVNTFSSEV---VTLWYRAPDVL 180 I+HRDLKP N+L+ N G++K + DFGL + + ++FS T + AP++L Sbjct: 142 IVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEML 201 Query: 181 MGSRTY--STSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 + ++DI+S GC+ +I+ G F G + + Q ++ +G N + Sbjct: 202 SEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANIL---LGACNLDCF---- 253 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 H+ + D + + ++ ++P R SAK L HP+F Sbjct: 254 -----------------------HSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >4Y83-A nrPDB Length = 332 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 61/281 (21%), Positives = 105/281 (37%), Gaps = 40/281 (14%) Query: 15 NGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHT 74 G + VY + T +A K + +D + + + + +HENI LY + Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD------VEIQACFRHENIAELYGAVLW 136 Query: 75 ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDL 134 + L E + ++ R E+ V +L+GL F H K++H D+ Sbjct: 137 GETVHLFMEAGEGG--SVLEKLESCGPMREFEIIWVTK---HVLKGLDFLHSKKVIHHDI 191 Query: 135 KPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWS 194 KP N++ + L DFGL+ V T Y +P+V++ R +ST DI+S Sbjct: 192 KPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL-CRGHSTKADIYS 249 Query: 195 CGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDL 254 G L M TG P + + P + + + K P ++ Sbjct: 250 LGATLIHMQTGTPPW--------------VKRYPRSAYPSYLYIIHKQAPPLED------ 289 Query: 255 RQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHP 295 + + + + L+ NP+ R A L H Sbjct: 290 -------IADDCSPGMRELIEASLERNPNHRPRAADLLKHE 323 >3SOC-A nrPDB Length = 322 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 114/303 (37%), Gaps = 43/303 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 + LE G + V+K YVA+K + ++ + E+ + +KHENI+ Sbjct: 26 LQLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNE--YEVYSLPGMKHENIL 81 Query: 67 RLYDVIHTEN----KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 + L L+ F + L ++ + V N + + + +GL Sbjct: 82 QFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVV-------SWNELCHIAETMARGL 134 Query: 122 AFCHE----------NKILHRDLKPQNLLINKRGQLKLGDFGLARAF--GIPVNTFSSEV 169 A+ HE I HRD+K +N+L+ + DFGLA F G +V Sbjct: 135 AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV 194 Query: 170 VTLWYRAPDVLMGSRTYST----SIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIM 225 T Y AP+VL G+ + ID+++ G +L E+ + G DE L +I Sbjct: 195 GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG 254 Query: 226 GTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMR 285 P+ V K P ++ + L + + + + R Sbjct: 255 QHPSLEDMQEVVVHKKKRPVLRDYWQK-----------HAGMAMLCETIEECWDHDAEAR 303 Query: 286 LSA 288 LSA Sbjct: 304 LSA 306 >6NT9-A nrPDB Length = 742 Score = 176 bits (447), Expect = 9e-45, Method: Composition-based stats. Identities = 65/240 (27%), Positives = 103/240 (42%), Gaps = 24/240 (10%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 + LG G A V++G +K TG A+K S +RE ++K+L H+NIV+L+ Sbjct: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 Query: 71 VIHTEN--KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 + L+ EF L ++ + GL + ++ G+ EN Sbjct: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEE---PSNAYGLPESEFLIVLRDVVGGMNHLREN 129 Query: 128 KILHRDLKPQNLL--INKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG- 182 I+HR++KP N++ I + GQ KL DFG AR F S T Y PD+ Sbjct: 130 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYERA 188 Query: 183 ------SRTYSTSIDIWSCGCILAEMITGKPLFP----GTNDEEQLKLIFDIMGTPNESL 232 + Y ++D+WS G TG F ++E + I I G P+ ++ Sbjct: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI--ITGKPSGAI 246 >6O8B-A nrPDB Length = 665 Score = 176 bits (447), Expect = 9e-45, Method: Composition-based stats. Identities = 64/240 (26%), Positives = 102/240 (42%), Gaps = 24/240 (10%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 + LG G A V++G +K TG A+K S +RE ++K+L H+NIV+L+ Sbjct: 21 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 80 Query: 71 VIHTEN--KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 + L+ EF L ++ + GL + ++ G+ EN Sbjct: 81 IEEETTTRHKVLIMEFCPCGSLYTVLEE---PSNAYGLPESEFLIVLRDVVGGMNHLREN 137 Query: 128 KILHRDLKPQNLL--INKRGQ--LKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG- 182 I+HR++KP N++ I + GQ KL DFG AR F T Y PD+ Sbjct: 138 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVELYGTEEYLHPDMYERA 196 Query: 183 ------SRTYSTSIDIWSCGCILAEMITGKPLFP----GTNDEEQLKLIFDIMGTPNESL 232 + Y ++D+WS G TG F ++E + I I G P+ ++ Sbjct: 197 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI--ITGKPSGAI 254 >6HV0-A nrPDB Length = 416 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 75/300 (25%), Positives = 126/300 (42%), Gaps = 55/300 (18%) Query: 11 EKLGNGTYAT-VYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HENIVRL 68 + LG+G T VY+G+ VA+K + + S A RE+ L++E H N++R Sbjct: 14 DVLGHGAEGTIVYRGMF--DNRDVAVKRILPECF----SFADREVQLLRESDEHPNVIRY 67 Query: 69 YDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 + + E L++Y++ + + GLE Q GLA H Sbjct: 68 FCTEKDRQFQYIAIELCAATLQEYVEQKDFAHL--GLEPIT---LLQQTTSGLAHLHSLN 122 Query: 129 ILHRDLKPQNLLI---NKRGQLK--LGDFGLARAFGIPVNTFSSEV---VTLWYRAPDVL 180 I+HRDLKP N+LI N G++K + DFGL + + ++FS T + AP++L Sbjct: 123 IVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEML 182 Query: 181 MG--SRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 + ++DI+S GC+ +I+ G F G + + Q ++ Sbjct: 183 SEDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACSL---------- 231 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 L P E + + + ++ ++P R SAK L HP+F Sbjct: 232 ------------------DCLHPEKHEDV--IARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >3UIU-A nrPDB Length = 306 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 65/318 (20%), Positives = 119/318 (37%), Gaps = 79/318 (24%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 FK++E +G+G + V+K ++ G ++ VK ++E+ RE+ + +L H NI Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAE-----REVKALAKLDHVNI 67 Query: 66 VRLYDVI-----------------------------HTENKLTLVFEFMD-NDLKKYMDS 95 V L + EF D L+++++ Sbjct: 68 VHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK 127 Query: 96 RTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLA 155 R L+ L Q+ +G+ + H K++HRDLKP N+ + Q+K+GDFGL Sbjct: 128 RR----GEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLV 183 Query: 156 RAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDE 215 + S+ TL Y +P+ + S+ Y +D+++ G ILAE++ Sbjct: 184 TSLKNDGKRTRSK-GTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL------------ 229 Query: 216 EQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLH 275 + + + K+ + + D L Sbjct: 230 ---------------HVCDTAFETSKF-----------FTDLRDGIISDIFDKKEKTLLQ 263 Query: 276 GLLQLNPDMRLSAKQALH 293 LL P+ R + + L Sbjct: 264 KLLSKKPEDRPNTSEILR 281 >4FL3-A nrPDB Length = 635 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 53/234 (22%), Positives = 103/234 (44%), Gaps = 20/234 (8%) Query: 11 EKLGNGTYATVYKGLNK-----TTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 ++LG+G + TV KG + T LK ++ + E ++M++L + I Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILK--NEANDPALKDELLAEANVMQQLDNPYI 432 Query: 66 VRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 VR+ + E LV E + L KY+ R ++ + Q+ G+ + Sbjct: 433 VRMIGICEAE-SWMLVMEMAELGPLNKYLQQN------RHVKDKNIIELVHQVSMGMKYL 485 Query: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLM 181 E+ +HRDL +N+L+ + K+ DFGL++A N + ++ W + AP+ + Sbjct: 486 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 Query: 182 GSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 + +S+ D+WS G ++ E + G+ + G E ++ + P Sbjct: 546 YYK-FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCP 598 >3MDY-A nrPDB Length = 337 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 73/309 (23%), Positives = 117/309 (37%), Gaps = 49/309 (15%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKE--LK 61 + Q + ++++G G Y V+ G K G VA+K E RE + + ++ Sbjct: 36 AKQIQMVKQIGKGRYGEVWMG--KWRGEKVAVKVFFTTEEAS----WFRETEIYQTVLMR 89 Query: 62 HENIVRLYDVIHTEN----KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 HENI+ +L L+ ++ + L Y+ S T L+ + + Sbjct: 90 HENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT-------LDAKSMLKLAYS 142 Query: 117 LLQGLAFCH--------ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF--- 165 + GL H + I HRDLK +N+L+ K G + D GLA F N Sbjct: 143 SVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIP 202 Query: 166 -SSEVVTLWYRAPDVLMGS--RTYSTS---IDIWSCGCILAEMITGKPLFPGTNDEEQLK 219 ++ V T Y P+VL S R + S D++S G IL E+ G +E QL Sbjct: 203 PNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS-GGIVEEYQLP 261 Query: 220 LIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQ 279 + P+ + + K P+ R D + + Sbjct: 262 YHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSD-----------ECLRQMGKLMTECWA 310 Query: 280 LNPDMRLSA 288 NP RL+A Sbjct: 311 HNPASRLTA 319 >6B2Q-A nrPDB Length = 317 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 55/218 (25%), Positives = 91/218 (41%), Gaps = 16/218 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKELK 61 S +++ + G V++ ++ G VA+K +K + S+ E L Sbjct: 31 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN 90 Query: 62 HENIVRLYDVIH-----TENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQW 115 H I ++D LV E ++ + L + L L Sbjct: 91 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR------LSLRHALDMLE 144 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV-VTLWY 174 Q + L H ++HRD+KP N+LI GQ+K+ DFG+A+A T + V T Y Sbjct: 145 QTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQY 204 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGT 212 AP+ +G S + D++S G + E ++GK F G Sbjct: 205 IAPEQALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 241 >4X3F-A nrPDB Length = 337 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 55/218 (25%), Positives = 91/218 (41%), Gaps = 16/218 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKELK 61 S +++ + G V++ ++ G VA+K +K + S+ E L Sbjct: 11 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN 70 Query: 62 HENIVRLYDVIH-----TENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQW 115 H I ++D LV E ++ + L + L L Sbjct: 71 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR------LSLRHALDMLE 124 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV-VTLWY 174 Q + L H ++HRD+KP N+LI GQ+K+ DFG+A+A T + V T Y Sbjct: 125 QTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQY 184 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGT 212 AP+ +G S + D++S G + E ++GK F G Sbjct: 185 IAPEQALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 221 >4OW8-A nrPDB Length = 283 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 55/218 (25%), Positives = 91/218 (41%), Gaps = 16/218 (7%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKELK 61 S +++ + G V++ ++ G VA+K +K + S+ E L Sbjct: 10 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLN 69 Query: 62 HENIVRLYDVIH-----TENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQW 115 H I ++D LV E ++ + L + L L Sbjct: 70 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR------LSLRHALDMLE 123 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV-VTLWY 174 Q + L H ++HRD+KP N+LI GQ+K+ DFG+A+A T + V T Y Sbjct: 124 QTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQY 183 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGT 212 AP+ +G S + D++S G + E ++GK F G Sbjct: 184 IAPEQALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 220 >1PY5-A nrPDB Length = 326 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 113/302 (37%), Gaps = 49/302 (16%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMK--ELKHENIVRL 68 E +G G + V++G K G VA+K + RE + + L+HENI+ Sbjct: 35 ESIGKGRFGEVWRG--KWRGEEVAVKIF----SSREERSWFREAEIYQTVMLRHENILGF 88 Query: 69 YDVIHTEN----KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 + +N +L LV ++ + L Y++ TV + + GLA Sbjct: 89 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTV-------TVEGMIKLALSTASGLAH 141 Query: 124 CH--------ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF----SSEVVT 171 H + I HRDLK +N+L+ K G + D GLA +T + V T Sbjct: 142 LHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGT 201 Query: 172 LWYRAPDVLMGSRTYS-----TSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMG 226 Y AP+VL S DI++ G + E+ + G +++ QL + Sbjct: 202 KRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPS 260 Query: 227 TPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL 286 P+ V K PNI R + E L + N RL Sbjct: 261 DPSVEEMRKVVCEQKLRPNIPNRW----------QSCEALRVMAK-IMRECWYANGAARL 309 Query: 287 SA 288 +A Sbjct: 310 TA 311 >2QKW-B nrPDB Length = 321 Score = 171 bits (435), Expect = 2e-43, Method: Composition-based stats. Identities = 60/293 (20%), Positives = 120/293 (40%), Gaps = 25/293 (8%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 +++ F +G+G + VYKG+ + G VALK +S +G I + +H Sbjct: 37 ATNNFDHKFLIGHGVFGKVYKGVLR-DGAKVALKRRTPESSQGIEEFETE-IETLSFCRH 94 Query: 63 ENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 ++V L N++ L++++M+ +LK+++ + + +GL Sbjct: 95 PHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTM--SMSWEQRLEICIGAARGL 152 Query: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV--VTLWYRAPDV 179 + H I+HRD+K N+L+++ K+ DFG+++ T S V TL Y P+ Sbjct: 153 HYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEY 212 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKL 239 + R + D++S G +L E++ + + E + L + + N + Sbjct: 213 FIKGR-LTEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQLEQIVD- 270 Query: 240 PKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 +L ++P + + L L+ + R S L Sbjct: 271 ------------PNLADKIRPESLRKFGDTAV----KCLALSSEDRPSMGDVL 307 >5C26-A nrPDB Length = 299 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 54/232 (23%), Positives = 104/232 (44%), Gaps = 16/232 (6%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTP---STAIREISLMKELKHENIVR 67 ++LG+G + TV KG + V + L +E P + E ++M++L + IVR Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 68 LYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 + + E LV E + L KY+ R ++ + Q+ G+ + E Sbjct: 93 MIGICEAE-SWMLVMEMAELGPLNKYLQQN------RHVKDKNIIELVHQVSMGMKYLEE 145 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLMGS 183 + +HRDL +N+L+ + K+ DFGL++A N + ++ W + AP+ + Sbjct: 146 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 205 Query: 184 RTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 + +S+ D+WS G ++ E + G+ + G E ++ + P Sbjct: 206 K-FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCP 256 >3QD2-B nrPDB Length = 332 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 65/336 (19%), Positives = 119/336 (35%), Gaps = 79/336 (23%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 + F+ ++ +G G + V++ NK A+K ++L + E +RE+ + +L+H Sbjct: 6 TDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 65 Query: 65 I---------------------------------------------VRLYDVIHTEN--- 76 I +R D T+N Sbjct: 66 IVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVG 125 Query: 77 ---------KLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 L + + +LK +M+ R E + + Q+ + + F H Sbjct: 126 QLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLED---REHGVCLHIFIQIAEAVEFLHS 182 Query: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN------------TFSSEVVTLWY 174 ++HRDLKP N+ +K+GDFGL A T + +V T Y Sbjct: 183 KGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLY 242 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 +P+ + G+ YS +DI+S G IL E++ + + E++++I D+ L+ Sbjct: 243 MSPEQIHGN-NYSHKVDIFSLGLILFELL-----YSFSTQMERVRIITDVRNLKFPLLFT 296 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNL 270 P R + + NL Sbjct: 297 QKYPQEHMMVQDMLSPSPTERPEATDIIENAIFENL 332 >4F9B-A nrPDB Length = 361 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 76/359 (21%), Positives = 140/359 (38%), Gaps = 83/359 (23%) Query: 4 SSQFKQLEKLGNGTYATVYKG---LNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 S+ FK +K+G GT+++VY L +ALK + S I + EL Sbjct: 20 SNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP---------IRIAAEL 70 Query: 61 KH-------ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYF 113 + +N++ + + + + +++++ + + L V+ + Sbjct: 71 QCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHE--------SFLDILNSLSFQEVREY 122 Query: 114 QWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLK-LGDFGLARAFGIPV---------- 162 L + L H+ I+HRD+KP N L N+R + L DFGLA+ Sbjct: 123 MLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSE 182 Query: 163 ------------------NTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT 204 + T +RAP+VL +T+ID+WS G I +++ Sbjct: 183 AQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLS 242 Query: 205 GKPLFP-GTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQ---- 259 G+ F ++D L I I G + + K ++ P +DLR++ + Sbjct: 243 GRYPFYKASDDLTALAQIMTIRG--SRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRG 300 Query: 260 -----PHTKEPLDGNLMDFLHGLLQL--------------NPDMRLSAKQALHHPWFAE 299 P + G+ + G ++ NP R++A++AL HP+F + Sbjct: 301 MDSSTPKLTSDIQGHATNL-EGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKD 358 >3MY0-A nrPDB Length = 305 Score = 170 bits (432), Expect = 6e-43, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 109/315 (34%), Gaps = 71/315 (22%) Query: 9 QLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKE--LKHENIV 66 +E +G G Y V++GL G VA+K E+ RE + L+H+NI+ Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQS----WFRETEIYNTVLLRHDNIL 65 Query: 67 RLYDVIHTE----NKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 T +L L+ + + L ++ +T LE +L GL Sbjct: 66 GFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQT-------LEPHLALRLAVSAACGL 118 Query: 122 AFCH--------ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTF----SSEV 169 A H + I HRD K +N+L+ Q + D GLA + + V Sbjct: 119 AHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRV 178 Query: 170 VTLWYRAPDVLMGS------RTYSTSIDIWSCGCILAEMITG----------KPLFPGTN 213 T Y AP+VL +Y DIW+ G +L E+ +P F Sbjct: 179 GTKRYMAPEVLDEQIRTDCFESY-KWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVV 237 Query: 214 DEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDF 273 + PS + K QQ P + +P+ L Sbjct: 238 PND-----------------PSFEDMKKVVCVDQQTPT-----IPNRLAADPVLSGLAQM 275 Query: 274 LHGLLQLNPDMRLSA 288 + NP RL+A Sbjct: 276 MRECWYPNPSARLTA 290 >5XD6-A nrPDB Length = 305 Score = 170 bits (432), Expect = 6e-43, Method: Composition-based stats. Identities = 55/214 (25%), Positives = 95/214 (44%), Gaps = 13/214 (6%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 + + +G G+Y V+ G+ K +G A+K KLDS + + ++S++ L+ E Sbjct: 21 TDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIK--KLDSSKQPDQEFLAQVSMVSRLRQE 77 Query: 64 NIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRG---LELNLVKYFQWQLLQ 119 N+V L L +E+ L + R + L + + Sbjct: 78 NVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAAR 137 Query: 120 GLAFCHEN---KILHRDLKPQNLLINKRGQLKLGDFGLARA-FGIPVNTFSSEV-VTLWY 174 GL + HE ++HRD+K N+L+ K+ DF L+ + S+ V T Y Sbjct: 138 GLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGY 197 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPL 208 AP+ M + T ST D++S G +L E++TG+ Sbjct: 198 HAPEYAM-TGTLSTKSDVYSFGVVLLELLTGRKP 230 >4IDT-A nrPDB Length = 356 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 121/312 (38%), Gaps = 64/312 (20%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 +LG G++ V++ +K TG A+K+V+L+ E+ L IV LY Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRA------EELMACAGLTSPRIVPLYGA 134 Query: 72 IHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 + + + E ++ L + + + L + Y+ Q L+GL + H +IL Sbjct: 135 VREGPWVNIFMELLEGGSLGQLVKEQGC------LPEDRALYYLGQALEGLEYLHSRRIL 188 Query: 131 HRDLKPQNLLINKRG-QLKLGDFGLARAF---GIPVNTFSSEV--VTLWYRAPDVLMGSR 184 H D+K N+L++ G L DFG A G+ + + + T + AP+V++G R Sbjct: 189 HGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG-R 247 Query: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 + +D+WS C++ M+ G + L + P P Sbjct: 248 SCDAKVDVWSSCCMMLHMLNGCHPW---------------TQFFRGPLCLKIASEP---P 289 Query: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA------------- 291 +++ PP + PL + L+ P R+SA + Sbjct: 290 PVREIPP----------SCAPLTAQA---IQEGLRKEPIHRVSAAELGGKVNRALQQVGG 336 Query: 292 LHHPWFAEYYHH 303 L PW EY Sbjct: 337 LKSPWRGEYKEP 348 >3LMG-A nrPDB Length = 344 Score = 167 bits (423), Expect = 6e-42, Method: Composition-based stats. Identities = 50/237 (21%), Positives = 103/237 (43%), Gaps = 15/237 (6%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGV----YVALKEVKLDSEEGTPSTAIREISLMKEL 60 ++ ++L+ LG+G + TV+KG+ G V +K ++ S + + + L Sbjct: 31 TELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSL 90 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H +IVRL + + L LV +++ L ++ P+ L + Q+ + Sbjct: 91 DHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLL-----LNWGVQIAK 144 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT--FSSEVVTLWYRAP 177 G+ + E+ ++HR+L +N+L+ Q+++ DFG+A +S + + A Sbjct: 145 GMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMAL 204 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 + + Y+ D+WS G + E++T G + G E L+ + Sbjct: 205 ESIH-FGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQIC 260 >2QLU-A nrPDB Length = 314 Score = 166 bits (422), Expect = 8e-42, Method: Composition-based stats. Identities = 74/304 (24%), Positives = 116/304 (38%), Gaps = 44/304 (14%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIV 66 + LE G + V+K +VA+K L ++ S REI +KHEN++ Sbjct: 17 LQLLEIKARGRFGCVWKAQLMND--FVAVKIFPLQDKQSWQSE--REIFSTPGMKHENLL 72 Query: 67 RLYDVIHTEN----KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 + + +L L+ F D L Y+ + N + + + +GL Sbjct: 73 QFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNI-------ITWNELCHVAETMSRGL 125 Query: 122 AFCHE-----------NKILHRDLKPQNLLINKRGQLKLGDFGLARAF--GIPVNTFSSE 168 ++ HE I HRD K +N+L+ L DFGLA F G P + Sbjct: 126 SYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQ 185 Query: 169 VVTLWYRAPDVLMGSRTYST----SIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDI 224 V T Y AP+VL G+ + ID+++ G +L E+++ G DE L +I Sbjct: 186 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEI 245 Query: 225 MGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDM 284 P+ V K P I+ K P L + + + Sbjct: 246 GQHPSLEELQEVVVHKKMRPTIKDHW-----------LKHPGLAQLCVTIEECWDHDAEA 294 Query: 285 RLSA 288 RLSA Sbjct: 295 RLSA 298 >3G2F-A nrPDB Length = 336 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 72/318 (22%), Positives = 121/318 (38%), Gaps = 56/318 (17%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMK--ELKH 62 K LE +G G Y VYKG VA+K + + I E ++ + ++H Sbjct: 13 DNLKLLELIGRGRYGAVYKGSLDE--RPVAVKVFSFANRQN----FINEKNIYRVPLMEH 66 Query: 63 ENIVRLY---DVIHTENKL--TLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 +NI R + + + ++ LV E+ L KY+ T + Sbjct: 67 DNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS-------DWVSSCRLAHS 119 Query: 117 LLQGLAFCH---------ENKILHRDLKPQNLLINKRGQLKLGDFGLARAF--------G 159 + +GLA+ H + I HRDL +N+L+ G + DFGL+ G Sbjct: 120 VTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPG 179 Query: 160 IPVNTFSSEVVTLWYRAPDVLMG------SRTYSTSIDIWSCGCILAEMITGKP-LFPGT 212 N SEV T+ Y AP+VL G + +D+++ G I E+ LFPG Sbjct: 180 EEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGE 239 Query: 213 N-DEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLM 271 + E Q+ ++ P + K P + + V +L Sbjct: 240 SVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAV----------RSLK 289 Query: 272 DFLHGLLQLNPDMRLSAK 289 + + + + RL+A+ Sbjct: 290 ETIEDCWDQDAEARLTAQ 307 >4G3E-A nrPDB Length = 352 Score = 164 bits (415), Expect = 5e-41, Method: Composition-based stats. Identities = 52/205 (25%), Positives = 95/205 (46%), Gaps = 20/205 (9%) Query: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDV 71 ++G G++ V++ +K TG A+K+V+L+ + E+ L IV LY Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR------VEELVACAGLSSPRIVPLYGA 134 Query: 72 IHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 + + + E ++ L + + L + Y+ Q L+GL + H +IL Sbjct: 135 VREGPWVNIFMELLEGGSLGQLIKQMGC------LPEDRALYYLGQALEGLEYLHTRRIL 188 Query: 131 HRDLKPQNLLINKRG-QLKLGDFGLARAF---GIPVNTFSSEV--VTLWYRAPDVLMGSR 184 H D+K N+L++ G + L DFG A G+ + + + T + AP+V+MG + Sbjct: 189 HGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-K 247 Query: 185 TYSTSIDIWSCGCILAEMITGKPLF 209 +DIWS C++ M+ G + Sbjct: 248 PCDAKVDIWSSCCMMLHMLNGCHPW 272 >2BUJ-A nrPDB Length = 317 Score = 164 bits (415), Expect = 5e-41, Method: Composition-based stats. Identities = 65/315 (20%), Positives = 111/315 (35%), Gaps = 56/315 (17%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 + + ++KLG G ++ V G + ALK + L E+ A RE + + H Sbjct: 27 DNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRI-LCHEQQDREEAQREADMHRLFNH 85 Query: 63 ENIVRLYDVIHTEN----KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 NI+RL E + L+ F L ++ + + L + + + + Sbjct: 86 PNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIER--LKDKGNFLTEDQILWLLLGI 143 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN---------TFSSE 168 +GL H HRDLKP N+L+ GQ L D G I V ++++ Sbjct: 144 CRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQ 203 Query: 169 VVTLWYRAPDV--LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMG 226 T+ YRAP++ + D+WS GC+L M+ G+ + Sbjct: 204 RCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY----------------- 246 Query: 227 TPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMR- 285 ++ L L L+ ++ ++P R Sbjct: 247 --------------DMVFQKGDSVALAVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRP 292 Query: 286 -----LSAKQALHHP 295 LS +AL P Sbjct: 293 HIPLLLSQLEALQPP 307 >5AR8-A nrPDB Length = 326 Score = 160 bits (405), Expect = 7e-40, Method: Composition-based stats. Identities = 57/295 (19%), Positives = 109/295 (36%), Gaps = 40/295 (13%) Query: 10 LEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE--EGTPSTAIREISLMKELKHENIVR 67 L L G TV + V VA+K + + + + +RE ++ + + I+ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 68 LYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 + + + L +V E+M L + + +T + L ++ G+ + H Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPD---VAWPLRFRILHEIALGVNYLHN 153 Query: 127 N--KILHRDLKPQNLLINKRGQLKLGDFGLAR-----AFGIPVNTFSSEVVTLWYRAPDV 179 +LH DLK QN+L++ +K+ DFGL++ + + E T+ Y P+ Sbjct: 154 MTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPEN 213 Query: 180 LMGSRT--YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 + S DI+S I E+++ K F + Q+ Sbjct: 214 YEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIM------------------ 255 Query: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQAL 292 Y+ + RP + + P ++ + NPD R S + L Sbjct: 256 ----YSVSQGHRPVINEESLP---YDIPHRARMISLIESGWAQNPDERPSFLKCL 303 >5CEK-A nrPDB Length = 263 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 61/282 (21%), Positives = 101/282 (35%), Gaps = 51/282 (18%) Query: 21 VYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHENIVRLYDVIHTENKLT 79 V + L TG + K + + I +L H NI + +VI E K Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRPYI-------QLPSHSNITGIVEVILGETKAY 77 Query: 80 LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNL 139 + FE D+ Y+ SR L Q++ +A CH++ I+ DLK + Sbjct: 78 VFFEKDFGDMHSYVRSRKR------LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKF 131 Query: 140 LIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYS-TSIDIWSCG 196 + + +R QL+L + S + Y +P++L + TYS + D+WS G Sbjct: 132 VFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLG 191 Query: 197 CILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQ 256 +L ++ G+ F ++ I E + P Sbjct: 192 VMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARC------------------ 233 Query: 257 VLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + LL+ P RL+A + L HPWF Sbjct: 234 ----------------LIRSLLRREPSERLTAPEILLHPWFE 259 >6DC0-A nrPDB Length = 292 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 61/282 (21%), Positives = 101/282 (35%), Gaps = 51/282 (18%) Query: 21 VYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHENIVRLYDVIHTENKLT 79 V + L TG + K + + I +L H NI + +VI E K Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRPYI-------QLPSHSNITGIVEVILGETKAY 74 Query: 80 LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNL 139 + FE D+ Y+ SR L Q++ +A CH++ I+ DLK + Sbjct: 75 VFFEKDFGDMHSYVRSRKR------LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKF 128 Query: 140 LIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYS-TSIDIWSCG 196 + + +R QL+L + S + Y +P++L + TYS + D+WS G Sbjct: 129 VFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLG 188 Query: 197 CILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQ 256 +L ++ G+ F ++ I E + P Sbjct: 189 VMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARC------------------ 230 Query: 257 VLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 + LL+ P RL+A + L HPWF Sbjct: 231 ----------------LIRSLLRREPSERLTAPEILLHPWFE 256 >2H34-A nrPDB Length = 309 Score = 158 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 60/281 (21%), Positives = 103/281 (36%), Gaps = 18/281 (6%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVK--LDSEEGTPSTAIREISLMKELKHEN 64 ++ +G G VY+ + VALK + L S+ + RE L+ + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 65 IVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 +V ++D + +L + ++ DL + + PR + Q+ L Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAV------AIVRQIGSALDA 149 Query: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPV-NTFSSEVVTLWYRAPDVLMG 182 H HRD+KP+N+L++ L DFG+A A + V TL+Y AP+ Sbjct: 150 AHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSE 209 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNE-------SLWPS 235 S + DI++ C+L E +TG P + G I + P+ + Sbjct: 210 SHA-TYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAV 268 Query: 236 VTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHG 276 + + NP + DL D L Sbjct: 269 IARGMAKNPEDRYVTCGDLSAAAHAALATADQDRATDILRR 309 >3SV0-A nrPDB Length = 483 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 29/237 (12%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH- 62 ++F+ K+G+G++ +Y G N T VA+K L++ + + E + + L+ Sbjct: 6 GNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK---LENVKTKHPQLLYESKIYRILQGG 62 Query: 63 ---ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 N VR + V + LV + + L+ + R L L V Q++ Sbjct: 63 TGIPN-VRWFGV--EGDYNVLVMDLLGPSLEDLFNF-----CSRKLSLKTVLMLADQMIN 114 Query: 120 GLAFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAF-------GIPVNTFSSEV 169 + F H LHRD+KP N L+ + Q+ + DFGLA+ + IP + Sbjct: 115 RVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLT 174 Query: 170 VTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGT---NDEEQLKLIFD 223 T Y + + +G S D+ S G +L + G + G +++ + I + Sbjct: 175 GTARYASVNTHLGIEQ-SRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISE 230 >4M66-A nrPDB Length = 325 Score = 156 bits (396), Expect = 8e-39, Method: Composition-based stats. Identities = 62/305 (20%), Positives = 114/305 (37%), Gaps = 50/305 (16%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 + S + K+LE +G G + V++ ++T VA+K V E+ M L Sbjct: 16 LVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW-------EVKAMVNL 68 Query: 61 KHENIVRLYDVIHTENK-----LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 ++EN++ L V LV FM+N + L+ Sbjct: 69 RNENVLLLLGVTEDLQWDFVSGQALVTRFMENG-----SLAGLLQPEAPRPWPLLCRLLQ 123 Query: 116 QLLQGLAFCHE--NKILHRDLKPQNLLINKRGQLKLGDFGLAR------AFGIPVNTFSS 167 +++ G+ + H +LHRDLKP N+L++ KL DFGL+ + + Sbjct: 124 EVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRD 183 Query: 168 EVVTLWYRAPDVLMG-SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMG 226 TL Y P++L + S + D++S G ++ ++ G+ Sbjct: 184 SGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR-------------------- 223 Query: 227 TPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL 286 L + + + + Q RPP L ++ + P L + + + R Sbjct: 224 --EAELVDKTSLIRETVCDRQSRPP--LTELPPGSPETPGLEKLKELMIHCWGSQSENRP 279 Query: 287 SAKQA 291 S + Sbjct: 280 SFQDC 284 >5TE0-A nrPDB Length = 347 Score = 156 bits (396), Expect = 9e-39, Method: Composition-based stats. Identities = 72/313 (23%), Positives = 118/313 (37%), Gaps = 66/313 (21%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HEN 64 Q E L G +A V+ + G+ ALK + +++E REI +M++L H+N Sbjct: 20 QVTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDL-QVCKREIQIMRDLSGHKN 77 Query: 65 IVRLYDVIHTEN------KLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 IV D ++ ++ +F + M+ R G N V Sbjct: 78 IVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQT----GFTENEVLQIFCDT 133 Query: 118 LQGLAFCHENK--ILHRDLKPQNLLINKRGQLKLGDFGLA-RAFGIPVNTFSSEV----- 169 + +A H+ K I+HRDLK +N+L++ RG L DFG A F P + V Sbjct: 134 CEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIK 193 Query: 170 --VTLWYRAPDV--LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIM 225 TL YRAP++ L + +T DIW+ GC+L ++ F Sbjct: 194 KYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF---------------- 237 Query: 226 GTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMR 285 G ++ +P + Q + +L+ +PD R Sbjct: 238 GESQVAICDGNFTIPDNSRYSQDMHC---------------------LIRYMLEPDPDKR 276 Query: 286 LSAKQALHHPWFA 298 Q +F+ Sbjct: 277 PDIYQV---SYFS 286 >6BFN-A nrPDB Length = 342 Score = 156 bits (394), Expect = 1e-38, Method: Composition-based stats. Identities = 49/216 (22%), Positives = 90/216 (41%), Gaps = 20/216 (9%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE---EGTPSTAIREISLMKELKH 62 F + K+G G + VY+ + + T A+K +K +++ + + E+ + +H Sbjct: 23 NFSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRH 80 Query: 63 ENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 NIV LV+ F+ L+ + +T P L + + Sbjct: 81 PNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPP--LSWPQRLDILLGTARAI 138 Query: 122 AFCH--ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFS---------SEVV 170 F H ++H D+K N+L+++R KLGDFGLAR ++ S + Sbjct: 139 QFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRG 198 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGK 206 TL Y + + R + D +S G ++ E + G+ Sbjct: 199 TLAYLPEEYIKTGR-LAVDTDTFSFGVVVLETLAGQ 233 >2Y4I-B nrPDB Length = 319 Score = 155 bits (392), Expect = 2e-38, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 116/306 (37%), Gaps = 43/306 (14%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHE 63 Q + E +G G + VY G VA++ + ++ + E RE+ ++ +HE Sbjct: 33 EQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE 89 Query: 64 NIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 N+V + L ++ L + + L++N + ++++G+ Sbjct: 90 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIV-----LDVNKTRQIAQEIVKGMG 144 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLAR-----AFGIPVNTFSSEVVTLWYRAP 177 + H ILH+DLK +N+ + G++ + DFGL G + + L + AP Sbjct: 145 YLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAP 203 Query: 178 DVL--------MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPN 229 +++ +S D+++ G I E+ + F E + MGT Sbjct: 204 EIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQ----MGTGM 259 Query: 230 ESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 + + + + + L + P LMD L L + N RLS Sbjct: 260 KPNLSQIGMGKEISDIL-------LFCWAFEQEERPTFTKLMDMLEKLPKRN--RRLS-- 308 Query: 290 QALHHP 295 HP Sbjct: 309 ----HP 310 >4BTK-A nrPDB Length = 337 Score = 154 bits (389), Expect = 5e-38, Method: Composition-based stats. Identities = 52/230 (22%), Positives = 97/230 (42%), Gaps = 19/230 (8%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HE 63 ++K L+K+G G + +Y+ ++ T VALK +S + E++++K+L+ + Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQVLKMEVAVLKKLQGKD 112 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 ++ R E +V + +L S+ G L+ Q+L+ + Sbjct: 113 HVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGT----FTLSTTLRLGKQILESIEA 168 Query: 124 CHENKILHRDLKPQNL----LINKRGQLKLGDFGLARAFGI------PVNTFSSEVVTLW 173 H LHRD+KP N L + + + DFGLAR + P + T+ Sbjct: 169 IHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVR 228 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFD 223 Y + + D+WS +L E G+ + D+EQ+ +I + Sbjct: 229 YASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 277 >2CHL-A nrPDB Length = 351 Score = 153 bits (387), Expect = 9e-38, Method: Composition-based stats. Identities = 60/288 (20%), Positives = 106/288 (36%), Gaps = 32/288 (11%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH-EN 64 F+ +K+G G + + G N T YVA+K + S E K+L + Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHL---EYRFYKQLGSGDG 87 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 I ++Y +V E + L+ D R L V QL+ + + Sbjct: 88 IPQVYYFGPCGKYNAMVLELLGPSLEDLFDL-----CDRTFSLKTVLMIAIQLISRMEYV 142 Query: 125 HENKILHRDLKPQNLLINKRGQ-----LKLGDFGLARAF-------GIPVNTFSSEVVTL 172 H +++RD+KP+N LI + G + + DF LA+ + IP S T Sbjct: 143 HSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTA 202 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG---TNDEEQLKLIFDIMG-TP 228 Y + + +G S D+ + G + + G + G +E+ + I D TP Sbjct: 203 RYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP 261 Query: 229 NESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHG 276 E L + ++ Y +++ + + L D Sbjct: 262 IEVLCENFPEMATYLRYVRRL------DFFEKPDYDYLRKLFTDLFDR 303 >4NFN-A nrPDB Length = 309 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 52/230 (22%), Positives = 97/230 (42%), Gaps = 19/230 (8%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HE 63 ++K L+K+G G + +Y+ ++ T VALK +S + E++++K+L+ + Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQVLKMEVAVLKKLQGKD 77 Query: 64 NIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 ++ R E +V + +L S+ G L+ Q+L+ + Sbjct: 78 HVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGT----FTLSTTLRLGKQILESIEA 133 Query: 124 CHENKILHRDLKPQNL----LINKRGQLKLGDFGLARAFGI------PVNTFSSEVVTLW 173 H LHRD+KP N L + + + DFGLAR + P + T+ Sbjct: 134 IHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVR 193 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFD 223 Y + + D+WS +L E G+ + D+EQ+ +I + Sbjct: 194 YASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 242 >4M69-B nrPDB Length = 283 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 57/288 (19%), Positives = 106/288 (36%), Gaps = 53/288 (18%) Query: 19 ATVYKGLNKTTGVYVALKEVKLDSEEGT---PSTAIREISLMKELKHENIVRLYDVIHT- 74 +T+Y+G + V +K E T EI MK+ NI+R++ + Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 75 ---ENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 + ++V E+ + L++ +D + L +++ + +GL H ++ L Sbjct: 81 TVKPPEFSIVMEYCELGTLRELLDR------EKDLTMSVRSLLVLRAARGLYRLHHSETL 134 Query: 131 HRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSS----EVVTLWYRAPDVLMGSRT- 185 HR++ + L+ Q+KL F L++ T S + Y +P+ L Sbjct: 135 HRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCL 194 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 Y +I+S G +L E+ TGK F G + ++ +L+ + K P Sbjct: 195 YDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAE---------------DKKQEPV 239 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 Q P L + ++ P R S L Sbjct: 240 GQDCP-----------------ELLREIINECRAHEPSQRPSVDGILE 270 >4MWI-A nrPDB Length = 294 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 104/291 (35%), Gaps = 57/291 (19%) Query: 19 ATVYKGLNKTTGVYVALKEVKL---DSEEGTPSTAIREISLMKELKHENIVRLYDVIHTE 75 +T+YKG VA+K K S T +EI MK+ + NI+R++ + E Sbjct: 38 STLYKGEYHRA--PVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDE 95 Query: 76 N----KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI- 129 + ++V E+ + L++ +D + L L +GL H ++ Sbjct: 96 TVTPPQFSIVMEYCELGTLRELLDR------EKDLTLGKRMVLVLGAARGLYRLHHSEAP 149 Query: 130 -LHRDLKPQNLLINKRGQLKLGDFGLARAFGI----PVNTFSSEVVTLWYRAPDVLMG-S 183 LH ++ N L+ + Q+KL F L + + V + Y +P L Sbjct: 150 ELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVF 209 Query: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLI-FDIMGTPNESLWPSVTKLPKY 242 Y +I+S G +L E+ TG F G N E+ KL+ P PS Sbjct: 210 YQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPS------- 262 Query: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 L + + +P +R S + L Sbjct: 263 --------------------------ELREIIDECRAHDPSVRPSVDEILK 287 >4BTF-A nrPDB Length = 469 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 57/288 (19%), Positives = 106/288 (36%), Gaps = 53/288 (18%) Query: 19 ATVYKGLNKTTGVYVALKEVKLDSEEGT---PSTAIREISLMKELKHENIVRLYDVIHT- 74 +T+Y+G + V +K E T EI MK+ NI+R++ + Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 75 ---ENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 + ++V E+ + L++ +D + L +++ + +GL H ++ L Sbjct: 267 TVKPPEFSIVMEYCELGTLRELLDR------EKDLTMSVRSLLVLRAARGLYRLHHSETL 320 Query: 131 HRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSS----EVVTLWYRAPDVLMGSRT- 185 HR++ + L+ Q+KL F L++ T S + Y +P+ L Sbjct: 321 HRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCL 380 Query: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 Y +I+S G +L E+ TGK F G + ++ +L+ + K P Sbjct: 381 YDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAE---------------DKKQEPV 425 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 Q P L + ++ P R S L Sbjct: 426 GQDCP-----------------ELLREIINECRAHEPSQRPSVDGILE 456 >5E8V-A nrPDB Length = 316 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 66/322 (20%), Positives = 110/322 (34%), Gaps = 72/322 (22%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTG----VYVALKEVKLD--SEEGTPSTAIREISLMKEL 60 + +G G +A VYK K VA+K + + T +I L Sbjct: 11 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDI----NL 66 Query: 61 KHENIVRLYDVIHTENKL----TLVFEF-MDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 KHENI++ + +L L+ F +L++Y+ + ++ Sbjct: 67 KHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHV-------ISWEDLRKLGS 119 Query: 116 QLLQGLAFCHE---------NKILHRDLKPQNLLINKRGQLKLGDFGLARAFG----IPV 162 L +G+A H I+HRDLK N+L+ L DFGL+ + Sbjct: 120 SLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDD 179 Query: 163 NTFSSEVVTLWYRAPDVLMGSRTYS-----TSIDIWSCGCILAEMITG----------KP 207 S +V T Y AP+VL + D++S +L EM + +P Sbjct: 180 LANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEP 239 Query: 208 LFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLD 267 F G+ E P V + RP ++ Sbjct: 240 PF-GSKVREH----------------PCVASMADNVLADAGRP-----EIPSFWLNHQGI 277 Query: 268 GNLMDFLHGLLQLNPDMRLSAK 289 + + L +P+ RL+A+ Sbjct: 278 QMVCETLTECWDHDPEARLTAQ 299 >4LQP-A nrPDB Length = 508 Score = 151 bits (381), Expect = 4e-37, Method: Composition-based stats. Identities = 36/162 (22%), Positives = 69/162 (42%), Gaps = 7/162 (4%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEV--KLDSEEGTPSTAIREISLMKELKH 62 F ++ +G G + V K TG A+K + ++ + E ++ Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 +V LY L L+ EF+ D T+ + ++ +++ + + + Sbjct: 162 PWVVSLYYSFQDAQYLYLIMEFLPGG-----DLMTMLIRWQLFTEDVTRFYMAECILAIE 216 Query: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT 164 H+ +HR +KP N+LI+ RG +KL DFGL+ F ++ Sbjct: 217 TIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDS 258 Score = 88.0 bits (217), Expect = 5e-18, Method: Composition-based stats. Identities = 31/135 (22%), Positives = 44/135 (32%), Gaps = 36/135 (26%) Query: 167 SEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMG 226 S V T Y AP++ + + Y D WS G I+ E + G P F +E + I + Sbjct: 322 STVGTPDYIAPEIFL-YQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMN--- 377 Query: 227 TPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL 286 Q LQ + D + LL D RL Sbjct: 378 ---------------------------FEQTLQFPDDIHISYEAEDLIRRLLTH-ADQRL 409 Query: 287 ----SAKQALHHPWF 297 A + HP+F Sbjct: 410 GRHGGADEIKSHPFF 424 >5IKW-A nrPDB Length = 310 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 120/311 (38%), Gaps = 63/311 (20%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HEN 64 Q E L G ++TV+ G+ ALK + +++ + REI++MKEL H+N Sbjct: 15 QVTLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDL-NVCKREITIMKELSGHKN 72 Query: 65 IVRLYDV---IHTEN--KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 IV D ++N ++ ++ E+ + ++ G V + Sbjct: 73 IVGYLDCAVNSISDNVWEVLILMEYCRAG---QVVNQMNKKLQTGFTEPEVLQIFCDTCE 129 Query: 120 GLAFCHENK--ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV------- 170 +A H+ K I+HRDLK +N+L+N G L DFG A + VV Sbjct: 130 AVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKY 189 Query: 171 -TLWYRAPDVLM--GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGT 227 TL YRAP+++ G + +T DIW+ GC+L ++ F G Sbjct: 190 TTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF----------------GE 233 Query: 228 PNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 ++ +P + N+ + +L+ +P+ R Sbjct: 234 SQVAICDGNFTIPDNSRY---------------------SRNIHCLIRFMLEPDPEHRPD 272 Query: 288 AKQALHHPWFA 298 Q +FA Sbjct: 273 IFQV---SYFA 280 >2C47-A nrPDB Length = 313 Score = 148 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 59/292 (20%), Positives = 106/292 (36%), Gaps = 31/292 (10%) Query: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK 61 S F+ +K+G G + + G N T YVA+K + S R + Sbjct: 1 SMGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSAT- 59 Query: 62 HENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 E + ++Y +V E + L+ D R L V QL+ + Sbjct: 60 -EGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDL-----CDRTFTLKTVLMIAIQLITRM 113 Query: 122 AFCHENKILHRDLKPQNLLINKRGQ-----LKLGDFGLARAF-------GIPVNTFSSEV 169 + H +++RD+KP+N L+ + G + + DFGLA+ + IP S Sbjct: 114 EYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLT 173 Query: 170 VTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG---TNDEEQLKLIFDIMG 226 T Y + + +G S D+ + G + + G + G +E+ + I D Sbjct: 174 GTARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKR 232 Query: 227 -TPNESLWPSVT-KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHG 276 TP E L + ++ Y +++ + + L D Sbjct: 233 ATPIEVLCENFPEEMATYLRYVRRL------DFFEKPDYDYLRKLFTDLFDR 278 >5FQD-C nrPDB Length = 341 Score = 148 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 57/252 (22%), Positives = 100/252 (39%), Gaps = 30/252 (11%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH- 62 ++K + K+G+G++ +Y +N T G VA+K L+S++ + E L K L+ Sbjct: 18 GGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK---LESQKARHPQLLYESKLYKILQGG 74 Query: 63 ---ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 +I R Y ++ LV + + L+ + R + V Q++ Sbjct: 75 VGIPHI-RWYG--QEKDYNVLVMDLLGPSLEDLFNF-----CSRRFTMKTVLMLADQMIS 126 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQL---KLGDFGLARAF-------GIPVNTFSSEV 169 + + H +HRD+KP N L+ L DFGLA+ + IP + Sbjct: 127 RIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLT 186 Query: 170 VTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG---TNDEEQLKLI-FDIM 225 T Y + + +G S D+ S G +L + G +++ + I M Sbjct: 187 GTARYASINAHLGIEQ-SRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKM 245 Query: 226 GTPNESLWPSVT 237 TP E L Sbjct: 246 STPVEVLCKGFP 257 >2CMW-A nrPDB Length = 310 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 62/288 (21%), Positives = 108/288 (37%), Gaps = 34/288 (11%) Query: 8 KQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH--ENI 65 + +K+G G + + G N T YVA+K + S E K+L E + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHL---EYRFYKQLGSAGEGL 59 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 ++Y +V E + L+ D R L V QLL + + H Sbjct: 60 PQVYYFGPCGKYNAMVLELLGPSLEDLFDL-----CDRTFTLKTVLMIAIQLLSRMEYVH 114 Query: 126 ENKILHRDLKPQNLLINKRGQ-----LKLGDFGLARAF-------GIPVNTFSSEVVTLW 173 +++RD+KP+N LI ++G + + DFGLA+ + IP S T Sbjct: 115 SKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTAR 174 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG---TNDEEQLKLIFDIMG-TPN 229 Y + + +G S D+ + G + + G + G +E+ + I D TP Sbjct: 175 YMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPI 233 Query: 230 ESLWPSVT-KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHG 276 E+L + ++ Y +++ + E L D Sbjct: 234 EALCENFPEEMATYLRYVRRL------DFFEKPDYEYLRTLFTDLFEK 275 >5X18-A nrPDB Length = 295 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 50/233 (21%), Positives = 94/233 (40%), Gaps = 23/233 (9%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 +K +K+G G++ +++G N GV VA+K +E + ++ NI Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGT--PNI 65 Query: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 Y LV + + L+ D R + V Q++ + H Sbjct: 66 PYAYYFGQEGLHNILVIDLLGPSLEDLFDW-----CGRKFSVKTVVQVAVQMITLIEDLH 120 Query: 126 ENKILHRDLKPQNLLINKRGQ-----LKLGDFGLARAF-------GIPVNTFSSEVVTLW 173 + +++RD+KP N LI + GQ + L DFG+A+ + IP S T Sbjct: 121 AHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTAR 180 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG---TNDEEQLKLIFD 223 Y + + +G S D+ + G + + G + G N++++ + I + Sbjct: 181 YMSINTHLGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGE 232 >5VC6-A nrPDB Length = 289 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 57/313 (18%), Positives = 110/313 (35%), Gaps = 64/313 (20%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD-SEEGTPSTAIREISLMKEL-K 61 +++F +LEK+G+G + +V+K + + G A+K K + A+RE+ L + Sbjct: 10 TTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQ 69 Query: 62 HENIVRLYDVIHTENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 H ++VR + ++ + + E+ L + + +K Q+ +G Sbjct: 70 HSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISEN--YRIMSYFKEAELKDLLLQVGRG 127 Query: 121 LAFCHENKILHRDLKPQNLLINKRG-------------------QLKLGDFGLARAFGIP 161 L + H ++H D+KP N+ I++ K+GD G P Sbjct: 128 LRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSP 187 Query: 162 VNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLI 221 + A +VL + T+ DI++ + G P + +Q I Sbjct: 188 QVEEGDS----RFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLP--RNGDQWHEI 240 Query: 222 FDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLN 281 RQ P + L + L ++ + Sbjct: 241 ---------------------------------RQGRLPRIPQVLSQEFTELLKVMIHPD 267 Query: 282 PDMRLSAKQALHH 294 P+ R SA + H Sbjct: 268 PERRPSAMALVKH 280 >5J0A-A nrPDB Length = 300 Score = 143 bits (362), Expect = 7e-35, Method: Composition-based stats. Identities = 60/302 (19%), Positives = 114/302 (37%), Gaps = 33/302 (10%) Query: 9 QLEKLGNGTYATVYKGLNKTTGV---YVALKEVKLDSEEGTPS----TAIREISLMKELK 61 ++KLG GT VY G+ A+K++ + S + E ++K L Sbjct: 13 FMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLH 72 Query: 62 HENIVRLYDVIH-TENKLTLVFEFM-DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 H NIV + L L E+ + L ++ R + ++ + + Sbjct: 73 HPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQD-PFPAAIILKVALNMAR 131 Query: 120 GLAFCH-ENKILHRDLKPQNLLINKRG-QLKLGDFGLARAFGIPVNTFSS---EVVTLWY 174 GL + H E K+LH D+K N++I +K+ D G++ + + T + Sbjct: 132 GLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPW 191 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWP 234 + + + + + DI++ G L EM+T D T +ES + Sbjct: 192 KPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP-----HINLSNDDDDEDKTFDESDFD 246 Query: 235 SVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK---QA 291 Y + RPP ++ ++ + + K +++ +P R SA +A Sbjct: 247 D----EAYYAALGTRPPINMEELDESYQK------VIELFSVCTNEDPKDRPSAAHIVEA 296 Query: 292 LH 293 L Sbjct: 297 LE 298 >4TN6-A nrPDB Length = 318 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 52/250 (20%), Positives = 94/250 (37%), Gaps = 24/250 (9%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH- 62 ++++ K+G+G++ +Y G + G VA+K L+ + E + K ++ Sbjct: 6 GNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK---LECVKTKHPQLHIESKIYKMMQGG 62 Query: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 I + + +V E + L+ + R L V Q++ + Sbjct: 63 VGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNF-----CSRKFSLKTVLLLADQMISRIE 117 Query: 123 FCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAF-------GIPVNTFSSEVVTL 172 + H +HRD+KP N L+ K + + DFGLA+ + IP + T Sbjct: 118 YIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTA 177 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDI----MGTP 228 Y + + +G S D+ S G +L G + G + + I M TP Sbjct: 178 RYASINTHLGIEQ-SRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTP 236 Query: 229 NESLWPSVTK 238 E L Sbjct: 237 IEVLCKGYPS 246 >5VDK-A nrPDB Length = 297 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 59/317 (18%), Positives = 114/317 (35%), Gaps = 70/317 (22%) Query: 2 SSSSQFKQ----LEKLGNGTYATVYKGLNKTTGVYVALKE-VKLDSEEGTPSTAIREISL 56 + +S++++ +EK+G G + TVYK + + G A+K +K +E ++A+ E+ Sbjct: 8 NMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYA 67 Query: 57 MKEL-KHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 L H ++VR Y ++ + + E+ + + S + E +K Sbjct: 68 HAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISEN-TKSGNHFEEPKLKDILL 126 Query: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQ-----------------------LKLGDF 152 Q+ GL + H + ++H D+KP N+ I + Q K+GD Sbjct: 127 QISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDL 186 Query: 153 GLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGT 212 G A + P E + A ++L + DI++ G +A Sbjct: 187 GHATSINKP----KVEEGDSRFLANEILQEDYRHLPKADIFALGLTIA------------ 230 Query: 213 NDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMD 272 V + P +R+ P + L + Sbjct: 231 -----------------------VAAGAESLPTNGAAW-HHIRKGNFPDVPQELSESFSS 266 Query: 273 FLHGLLQLNPDMRLSAK 289 L ++Q + + R SA Sbjct: 267 LLKNMIQPDAEQRPSAA 283 >5L2Q-C nrPDB Length = 320 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 55/307 (17%), Positives = 105/307 (34%), Gaps = 67/307 (21%) Query: 22 YKGLNKTTGVYVALKEVKLDS--EEGTPSTAIR--------EISLMKELK-HENIVRLYD 70 T + LK + L+ ++G S R E SL+ L + +V + Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 71 VIHT------------------ENKLTLVFE-FMDNDLKK----YMDSRTVGNTPRGLEL 107 + + ++ LV + +D ++ + + L Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 108 NLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQ-LKLGDFGLARAFGIPVNTFS 166 + +++ + H+ I+HRDLK N+++NKR + + +F L + + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 167 SEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMG 226 + + Y +PDVL G D+W+ G +L M+ G+ F + +E + I Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEY 272 Query: 227 TPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL 286 T E + N + + LL L+P RL Sbjct: 273 TIPED--------------------------------GRVSENTVCLIRKLLVLDPQQRL 300 Query: 287 SAKQALH 293 +A L Sbjct: 301 AAADVLE 307 >3VHK-A nrPDB Length = 368 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 39/194 (20%), Positives = 76/194 (39%), Gaps = 36/194 (18%) Query: 104 GLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN 163 L L + + +Q+ +G+ F K +HRDL +N+L++++ +K+ DFGLAR + Sbjct: 196 FLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPD 255 Query: 164 TFS--SEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKL 220 + L + AP+ + R Y+ D+WS G +L E+ + G +PG +E+ Sbjct: 256 YVRKGDARLPLKWMAPETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEF-- 312 Query: 221 IFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQL 280 R L++ + + + + Sbjct: 313 ------------------------------CRRLKEGTRMRAPDYTTPEMYQTMLDCWHG 342 Query: 281 NPDMRLSAKQALHH 294 P R + + + H Sbjct: 343 EPSQRPTFSELVEH 356 Score = 81.1 bits (199), Expect = 6e-16, Method: Composition-based stats. Identities = 25/106 (23%), Positives = 45/106 (42%), Gaps = 8/106 (7%) Query: 5 SQFKQLEKLGNGTYATVYK----GLNKT-TGVYVALKEVKLDSEEGTPSTAIREISLMKE 59 + K + LG G + V + G++KT T VA+K +K + + E+ ++ Sbjct: 29 DRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIH 88 Query: 60 LKHE-NIVRLYDVIHTE-NKLTLVFEFMD-NDLKKYMDSRTVGNTP 102 + H N+V L L ++ EF +L Y+ S+ P Sbjct: 89 IGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVP 134 >4NT4-A nrPDB Length = 312 Score = 140 bits (354), Expect = 6e-34, Method: Composition-based stats. Identities = 61/289 (21%), Positives = 108/289 (37%), Gaps = 32/289 (11%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN- 64 F+ +K+G G + + G N +VA+K + S+ R L+ H + Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLG--SHADN 70 Query: 65 ----IVRLYDVIHTENKL-TLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 I R+Y + + +V E + L+ + R L V QLL Sbjct: 71 APDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNI-----CARKFSLKTVLMIAKQLLH 125 Query: 120 GLAFCHENKILHRDLKPQNLLINKRGQ-----LKLGDFGLARAF-------GIPVNTFSS 167 + + H +++RD+KP+N LI + + + DFGLA+ + IP S Sbjct: 126 RIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKS 185 Query: 168 EVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG---TNDEEQLKLIFDI 224 T Y + + MG S D+ + G + + G + G +E+ + I D Sbjct: 186 LTGTARYMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDT 244 Query: 225 MG-TPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMD 272 TP E L + ++ ++ D + L +L D Sbjct: 245 KRATPIEVLCDGHPE--EFATYLRYVRRLDFFETPDYDFLRRLFQDLFD 291 >1CSN-A nrPDB Length = 298 Score = 136 bits (342), Expect = 1e-32, Method: Composition-based stats. Identities = 47/250 (18%), Positives = 91/250 (36%), Gaps = 26/250 (10%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH-EN 64 +K ++G G++ +++G N VA+K S+ R L+ N Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPN 70 Query: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 + Y LV + + L+ +D R + V Q+L + Sbjct: 71 V---YYFGQEGLHNVLVIDLLGPSLEDLLDL-----CGRKFSVKTVAMAAKQMLARVQSI 122 Query: 125 HENKILHRDLKPQNLLINKRGQ-----LKLGDFGLARAF-------GIPVNTFSSEVVTL 172 HE +++RD+KP N LI + + + DFG+ + + IP + T Sbjct: 123 HEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTA 182 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG---TNDEEQLKLI-FDIMGTP 228 Y + + +G S D+ + G + + G + G ++++ + I TP Sbjct: 183 RYMSINTHLGREQ-SRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTP 241 Query: 229 NESLWPSVTK 238 L + Sbjct: 242 LRELCAGFPE 251 >3HNG-A nrPDB Length = 360 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 39/198 (19%), Positives = 75/198 (37%), Gaps = 36/198 (18%) Query: 99 GNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF 158 G + + + + +Q+ +G+ F K +HRDL +N+L+++ +K+ DFGLAR Sbjct: 190 GFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDI 249 Query: 159 GIPVNTFS--SEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDE 215 + + L + AP+ + + YST D+WS G +L E+ + G +PG + Sbjct: 250 YKNPDYVRKGDTRLPLKWMAPESIFD-KIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMD 308 Query: 216 EQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLH 275 E LR+ ++ E + + Sbjct: 309 EDF--------------------------------CSRLREGMRMRAPEYSTPEIYQIML 336 Query: 276 GLLQLNPDMRLSAKQALH 293 +P R + + Sbjct: 337 DCWHRDPKERPRFAELVE 354 Score = 78.8 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 20/103 (19%), Positives = 40/103 (38%), Gaps = 8/103 (7%) Query: 3 SSSQFKQLEKLGNGTYATVYKG-----LNKTTGVYVALKEVKLDSEEGTPSTAIREISLM 57 + + K + LG G + V + T VA+K +K + + E+ ++ Sbjct: 25 ARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKIL 84 Query: 58 KELKHE-NIVRLYDVIH-TENKLTLVFEFMD-NDLKKYMDSRT 97 + H N+V L L ++ E+ +L Y+ S+ Sbjct: 85 THIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKR 127 >5USZ-A nrPDB Length = 289 Score = 134 bits (337), Expect = 5e-32, Method: Composition-based stats. Identities = 59/301 (19%), Positives = 107/301 (35%), Gaps = 60/301 (19%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVY-------VALKEVKLDSEEGTPSTAIREIS 55 + E LG GT+ ++KG+ + G Y V LK + + + S Sbjct: 6 RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLD-KAHRNYSESFFEAAS 64 Query: 56 LMKELKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQ 114 +M +L H+++V Y V ++ LV EF+ L Y+ + + Sbjct: 65 MMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNC-----INILWKLEVA 119 Query: 115 WQLLQGLAFCHENKILHRDLKPQNLLINKRGQ--------LKLGDFGLARAFGIPVNTFS 166 QL + F EN ++H ++ +N+L+ + +KL D G++ +P + Sbjct: 120 KQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITV-LPKDILQ 178 Query: 167 SEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMG 226 + + P+ + + + + D WS G L E+ +G G Sbjct: 179 ERI---PWVPPECIENPKNLNLATDKWSFGTTLWEICSG--------------------G 215 Query: 227 TPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL 286 S S KL Y Q P+ L + ++ + PD R Sbjct: 216 DKPLSALDSQRKLQFYEDRHQLPAPK--------------AAELANLINNCMDYEPDHRP 261 Query: 287 S 287 S Sbjct: 262 S 262 >4L00-A nrPDB Length = 304 Score = 133 bits (334), Expect = 1e-31, Method: Composition-based stats. Identities = 59/294 (20%), Positives = 104/294 (35%), Gaps = 52/294 (17%) Query: 6 QFKQLEKLGNGTYATVYKGL------NKTTGVYVALKEV--KLDSEEGTPSTAIREI-SL 56 Q E LG GT +Y G ++ T +K + LD S A E S+ Sbjct: 26 DLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASM 85 Query: 57 MKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 M+++ H++IV LY V + + +V EF++ R L Q Sbjct: 86 MRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRK----SDVLTTPWKFKVAKQ 141 Query: 117 LLQGLAFCHENKILHRDLKPQNLLINKRG-QLKLGDFGLARAFGIPVNTFSSE--VVTLW 173 L L++ + ++H ++ +NLL+ + G + G F GIP+ S + + + Sbjct: 142 LASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIP 201 Query: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESL 232 + AP+ + S+ S + D WS G L E+ G+ E Sbjct: 202 WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIE---------------- 245 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL 286 ++ + P L D + + +P+ R Sbjct: 246 -------------------KERFYESRCRPVTPSCKELADLMTRCMNYDPNQRP 280 >4RT7-A nrPDB Length = 415 Score = 129 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 42/189 (22%), Positives = 82/189 (43%), Gaps = 23/189 (12%) Query: 52 REISLMKELKHEN---IVRLYD-VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLEL 107 RE+ + H + I L+ H+E+++ E+ + +K ++ N L Sbjct: 198 REVQI-----HPDSDQISGLHGNSFHSEDEI----EYEN---QKRLEEEEDLNV---LTF 242 Query: 108 NLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT--F 165 + F +Q+ +G+ F +HRDL +N+L+ +K+ DFGLAR N Sbjct: 243 EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVR 302 Query: 166 SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDI 224 + + + + AP+ L Y+ D+WS G +L E+ + G +PG + + Sbjct: 303 GNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQN 361 Query: 225 MGTPNESLW 233 ++ + Sbjct: 362 GFKMDQPFY 370 Score = 93.4 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 24/100 (24%), Positives = 42/100 (42%), Gaps = 7/100 (7%) Query: 5 SQFKQLEKLGNGTYATVYKGL-----NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKE 59 + + LG+G + V + VA+K +K ++ + E+ +M + Sbjct: 65 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQ 124 Query: 60 L-KHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRT 97 L HENIV L + L+FE+ DL Y+ S+ Sbjct: 125 LGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR 164 >4XHH-A nrPDB Length = 403 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 57/300 (19%), Positives = 108/300 (36%), Gaps = 37/300 (12%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH--- 62 +F+ K+G+G++ +Y G N +G VA+ +L+S E + K L Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDYESRVYKYLSGGVG 64 Query: 63 -ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 I R + +V + + L+ + R V Q++ + Sbjct: 65 IPFI-RWFG--REGEYNAMVIDLLGPSLEDLFNY-----CHRKFSFKTVIMLALQMICRV 116 Query: 122 AFCHENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAF-------GIPVNTFSSEVVT 171 + H +HRD+KP N L+ + + + DFGL++ + IP S T Sbjct: 117 QYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGT 176 Query: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG---TNDEEQLKLIFDIMGTP 228 Y + + +G S D+ S G +L G + G T +++ I + Sbjct: 177 ARYASVNTHLGIEQ-SRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCI 235 Query: 229 NES-----LWPSVTKLPKYNPNIQ--QRPPRDLRQVLQPHTKEPLDGNLMDFLH-GLLQL 280 + L ++ Y N++ +RP L L+ + +L+ Sbjct: 236 SVETLCAGLPLEFSEYMNYCRNLKFDERPDYLYLARLFKDLSIKLEYHNDHLFDWTMLRY 295 >5C01-A nrPDB Length = 342 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 59/324 (18%), Positives = 104/324 (32%), Gaps = 77/324 (23%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTG------------------------VYVALKEV 38 + QL LG GT VY+G + G + V LK + Sbjct: 56 DQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVL 115 Query: 39 KLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTV 98 S SLM ++ H ++ ++ V + +V E++++ R Sbjct: 116 DP-SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRER 174 Query: 99 GNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQ-------LKLGD 151 G+ P ++ QL L++ ++H ++ +N+L+ + G +KL D Sbjct: 175 GHVPMAWKM----VVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSD 230 Query: 152 FGLARAFGIPVNTFSSEVVTLWYRAPDVL-MGSRTYSTSIDIWSCGCILAEMIT-GKPLF 209 G G+ + V + + AP+ L G+ + ST++D W G L E+ G+ Sbjct: 231 PG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPL 286 Query: 210 PGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGN 269 + E+ P EP Sbjct: 287 QSRSPSEKEHFYQRQHRLP-----------------------------------EPSCPQ 311 Query: 270 LMDFLHGLLQLNPDMRLSAKQALH 293 L L P R S + L Sbjct: 312 LATLTSQCLTYEPTQRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 128 bits (321), Expect = 4e-30, Method: Composition-based stats. Identities = 59/324 (18%), Positives = 104/324 (32%), Gaps = 77/324 (23%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTG------------------------VYVALKEV 38 + QL LG GT VY+G + G + V LK + Sbjct: 33 DQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVL 92 Query: 39 KLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTV 98 S SLM ++ H ++ ++ V + +V E++++ R Sbjct: 93 DP-SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRER 151 Query: 99 GNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQ-------LKLGD 151 G+ P ++ QL L++ ++H ++ +N+L+ + G +KL D Sbjct: 152 GHVPMAWKM----VVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSD 207 Query: 152 FGLARAFGIPVNTFSSEVVTLWYRAPDVL-MGSRTYSTSIDIWSCGCILAEMIT-GKPLF 209 G G+ + V + + AP+ L G+ + ST++D W G L E+ G+ Sbjct: 208 PG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPL 263 Query: 210 PGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGN 269 + E+ P EP Sbjct: 264 QSRSPSEKEHFYQRQHRLP-----------------------------------EPSCPQ 288 Query: 270 LMDFLHGLLQLNPDMRLSAKQALH 293 L L P R S + L Sbjct: 289 LATLTSQCLTYEPTQRPSFRTILR 312 >4XHL-A nrPDB Length = 394 Score = 126 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 47/232 (20%), Positives = 89/232 (38%), Gaps = 23/232 (9%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65 +F+ K+G+G++ +Y G N +G VA+ +L+S E + + L Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDYESRVYRYLSGGVG 64 Query: 66 VRLYDVIHTENKL-TLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 + E + +V + + L+ + R V Q+ + + Sbjct: 65 IPFIRWFGREGEYNAMVIDLLGPSLEDLFNY-----CHRRFSFKTVIMLALQMFCRIQYI 119 Query: 125 HENKILHRDLKPQNLLIN---KRGQLKLGDFGLARAF-------GIPVNTFSSEVVTLWY 174 H +HRD+KP N L+ + + + DFGL++ + IP S T Y Sbjct: 120 HGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARY 179 Query: 175 RAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPG---TNDEEQLKLIFD 223 + + +G S D+ S G +L G + G T +++ I + Sbjct: 180 ASVNTHLGIEQ-SRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIME 230 >4L68-A nrPDB Length = 340 Score = 125 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 49/213 (23%), Positives = 91/213 (42%), Gaps = 17/213 (7%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 M++++ F + + T YK L G +A+K + + + E++ + EL Sbjct: 36 MAATNNFNSENIIVSTRTGTTYKALL-PDGSALAVKHLS--TCKLGEREFRYEMNQLWEL 92 Query: 61 KHENIVRLYDVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 +H N+ L E + LV+++M N L +DS L+ + + Sbjct: 93 RHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSNRGE-----LDWSTRFRIGLGAAR 147 Query: 120 GLAFCHE---NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT----FSSEVVTL 172 GLA+ H ILH+++ +LI++ ++ D GLAR N + ++ Sbjct: 148 GLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEF 207 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITG 205 Y AP+ + S D++ G +L E+ TG Sbjct: 208 GYVAPE-YSTTMLASLKGDVYGLGVVLLELATG 239 >2PZI-A nrPDB Length = 681 Score = 124 bits (312), Expect = 5e-29, Method: Composition-based stats. Identities = 41/205 (20%), Positives = 93/205 (45%), Gaps = 20/205 (9%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKT-TGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 + Q++ + +G +Y L++ G V LK + + + A+ E + E+ H Sbjct: 79 AGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVH 138 Query: 63 ENIVRLYDVIHTENKL-----TLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 +IV++++ + ++ +V E++ + + L + + ++ Sbjct: 139 PSIVQIFNFVEHTDRHGDPVGYIVMEYVGG-------QSLKRSKGQKLPVAEAIAYLLEI 191 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 L L++ H +++ DLKP+N+++ + QLKL D G N+F T ++AP Sbjct: 192 LPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRI----NSFGYLYGTPGFQAP 246 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEM 202 +++ + + DI++ G LA + Sbjct: 247 EIVRTGP--TVATDIYTVGRTLAAL 269 >4Y12-A nrPDB Length = 375 Score = 124 bits (311), Expect = 6e-29, Method: Composition-based stats. Identities = 41/205 (20%), Positives = 93/205 (45%), Gaps = 20/205 (9%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKT-TGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 + Q++ + +G +Y L++ G V LK + + + A+ E + E+ H Sbjct: 118 AGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVH 177 Query: 63 ENIVRLYDVIHTENKL-----TLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 +IV++++ + ++ +V E++ + + L + + ++ Sbjct: 178 PSIVQIFNFVEHTDRHGDPVGYIVMEYVGG-------QSLKRSKGQKLPVAEAIAYLLEI 230 Query: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 L L++ H +++ DLKP+N+++ + QLKL D G N+F T ++AP Sbjct: 231 LPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRI----NSFGYLYGTPGFQAP 285 Query: 178 DVLMGSRTYSTSIDIWSCGCILAEM 202 +++ + + DI++ G LA + Sbjct: 286 EIVRTGP--TVATDIYTVGRTLAAL 308 >5M07-A nrPDB Length = 276 Score = 121 bits (303), Expect = 5e-28, Method: Composition-based stats. Identities = 41/209 (19%), Positives = 79/209 (37%), Gaps = 26/209 (12%) Query: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVK--LDSEEGTPSTAIREISLMKELKHEN 64 + + LG VY + + ALK + + +++ RE + L H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 65 IVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 I+ ++D + +L + +++D D ++M R P L + V + L + Sbjct: 92 ILEVHDRGEFDGQLWIAMDYVDGIDATQHMADR----FPAVLPVGEVLAIVTAVAGALDY 147 Query: 124 CHENKILHRDLKPQNLLINK----RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 H+ +LHRD+ P N+++ ++ L DFG+A Y AP+ Sbjct: 148 AHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ--------------PSYPAPE- 192 Query: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPL 208 L D ++ + G P Sbjct: 193 LSAGADVDGRADQYALALTAIHLFAGAPP 221 >5X1R-A nrPDB Length = 302 Score = 120 bits (302), Expect = 7e-28, Method: Composition-based stats. Identities = 49/294 (16%), Positives = 99/294 (33%), Gaps = 41/294 (13%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST--------------- 49 ++F+ E +G G + VY+ + +A+KE S Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 50 -----AIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRG 104 I+E L+ H ++ + + +F K + ++ P Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQ----PEK 136 Query: 105 LELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT 164 ++ ++ L + H+ LHRD+ N+ I + L DFG AR ++ Sbjct: 137 IDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSD 196 Query: 165 FSSEVVTLWYRAPDVL--MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIF 222 + V+ + + DI++ G +L +I G P Sbjct: 197 ETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPPP------------V 244 Query: 223 DIMGTPNESLWPSVTKLPK-YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLH 275 ++ + +S P + P Y+P + + R L L+P + + + L Sbjct: 245 SVVRSIEDSYQPLTERRPAGYSPELLRTVDRALA--LKPEDRPQTIDEMAELLE 296 >4JRN-A nrPDB Length = 372 Score = 117 bits (293), Expect = 8e-27, Method: Composition-based stats. Identities = 63/315 (20%), Positives = 102/315 (32%), Gaps = 79/315 (25%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSE--EGTPSTAIREISLMKELK--------- 61 LG+G +ATVY+ + T +A+K + E + T RE S + Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 62 -------HENIVRLYD------VIH------TENKLTLVFEFMDNDLKKYMD--SRTVGN 100 ++V L V+ N L+ + D+ K + Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMR-AEADMSKVISWVFGDASV 194 Query: 101 TPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGI 160 L + Y Q ++ +A I+H D+KP N L+ K G+L LGDFG R Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRI--- 251 Query: 161 PVNTFSSEVVTLWYRAPDVLMGSRT--YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQL 218 N+ + T Y P+ + Y+ D W G L + + Sbjct: 252 -NNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP---------- 300 Query: 219 KLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLL 278 TP + +W + + P + D + LL Sbjct: 301 --------TPADGIWDYL--------HFADCPSTP--------------ELVQDLIRSLL 330 Query: 279 QLNPDMRLSAKQALH 293 +P R+ QAL Sbjct: 331 NRDPQKRMLPLQALE 345 >5UV4-A nrPDB Length = 311 Score = 111 bits (277), Expect = 5e-25, Method: Composition-based stats. Identities = 47/203 (23%), Positives = 82/203 (40%), Gaps = 10/203 (4%) Query: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 E +G + T YK G + +K +K + REI + ++H N+V L Sbjct: 31 EIIGRSCHGTSYKATL-DNGYMLTVKWLKEGFAKS-KKEFSREIKKLGSVRHPNLVPLRG 88 Query: 71 VI--HTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 E++ ++ ++ D L Y+ N P L + + L + H Sbjct: 89 YYWGPKEHERIMISDYADATSLSTYLSEFDERNLP-PLSAGQRLNIAIDIARCLDYLHNE 147 Query: 128 KIL-HRDLKPQNLLINKRGQLKL-GDFGLARAFG-IPVNTFSSEVVTLWYRAPDVLMGSR 184 +++ H ++K N+LI L D+ L R I + L Y P+ S+ Sbjct: 148 RVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSK 207 Query: 185 TY-STSIDIWSCGCILAEMITGK 206 S D+++ G IL E++TGK Sbjct: 208 PCPSLKSDVYAFGVILLELLTGK 230 >3REP-A nrPDB Length = 271 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 49/261 (18%), Positives = 102/261 (39%), Gaps = 23/261 (8%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKHEN 64 Q L KL ++KG + G + +K +K+ E ++ H N Sbjct: 11 QLNFLTKLNENHSGELWKGRWQ--GNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPN 68 Query: 65 IVRLYDVIHTEN--KLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 ++ + + TL+ +M L + T ++ + F + +G+ Sbjct: 69 VLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNF----VVDQSQAVKFALDMARGM 124 Query: 122 AFCHE-NKILHR-DLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 AF H ++ R L ++++I++ ++ + +F P ++ + AP+ Sbjct: 125 AFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQSPGRMYA-----PAWVAPEA 179 Query: 180 LMGSRTYS--TSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLI--FDIMGTPNESLWPS 235 L + S D+WS +L E++T + F ++ E + + T + P Sbjct: 180 LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPH 239 Query: 236 VTKLPK--YNPNIQQRPPRDL 254 V+KL K N + +RP D+ Sbjct: 240 VSKLMKICMNEDPAKRPKFDM 260 >6J6I-B nrPDB Length = 351 Score = 105 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 41/215 (19%), Positives = 76/215 (35%), Gaps = 10/215 (4%) Query: 33 VALKEVKLDSEEGTP---STAIREISL-MKELKHENIVRLYDVIHTENKLTLVFEFMDND 88 +K D G +I L + H N ++L LVFEF ++ Sbjct: 84 YMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFAEHG 143 Query: 89 LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE---NKILHRDLKPQNLLINKRG 145 V L ++ ++ + + H I+HRD+KP ++ ++K Sbjct: 144 AMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNW 203 Query: 146 QLKLGDFGLARAFGIPVNTFSSE--VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMI 203 KL D + + + +E + T Y P + + + D++S G L +I Sbjct: 204 TAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGICLLVII 262 Query: 204 TGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 TGKP +D + ++ + V Sbjct: 263 TGKPAIMTISDGDLQGILSLVRELCENGKLDEVID 297 >5OAT-A nrPDB Length = 411 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 58/349 (16%), Positives = 106/349 (30%), Gaps = 104/349 (29%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTT-----GVYVALKEVKLDSEEGTPSTAIR----- 52 + + + + GT VY K ALK + + ++ Sbjct: 9 TLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRE 68 Query: 53 ----------------EISLMKELKH----ENIVRLYDVIHT-----------------E 75 EI L KH NIV ++ V Sbjct: 69 TVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRN 128 Query: 76 NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLK 135 L L+ + D +L+ ++ + T L L+ +G+A + I HRDLK Sbjct: 129 MSLFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLL--------EGVAHMTAHGIAHRDLK 180 Query: 136 PQNLLIN----KRGQLKLGDFGLA-----RAFGIPVNTFS-SEVVTLWYRAPDVL-MGSR 184 NLL++ + L + DFG +P ++ + AP+++ Sbjct: 181 SDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPG 240 Query: 185 TYS----TSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLP 240 T+S + D+W+ G I E+ F G + + Sbjct: 241 TFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFN--------------------- 279 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 ++ P + + + + LL+ NP+ RL + Sbjct: 280 -------------YKEGDLPKLPDEVPTVIQALVANLLKRNPNKRLDPE 315 >4I94-A nrPDB Length = 300 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 48/271 (17%), Positives = 91/271 (33%), Gaps = 39/271 (14%) Query: 20 TVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENKLT 79 VYKG +A+K S + + E + +L++ + L + + + Sbjct: 44 VVYKGKL-ENQRRIAVKRFNRKSWPDSRQ-FLEEAKAVGQLRNHRMANLLGCCYEDEERL 101 Query: 80 LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK-ILHRDLKPQN 138 L+ EFM N+ + + ++ + + Q L +C L+ DL Sbjct: 102 LIAEFMPNET---LAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYR 158 Query: 139 LLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCI 198 +L + +L FGL + + ++ T P+ L R + I+S G + Sbjct: 159 VLFDDDANPRLSCFGLMKNSRDGKSYSTNLAFTP----PEYLRTGRV-TPESVIYSFGTL 213 Query: 199 LAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVL 258 L ++++GK + P L LI D + + L Sbjct: 214 LLDLLSGKHIPP----SHALDLIRD------------------------RNIQMLMDSGL 245 Query: 259 QPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 + L+ LQ P R + K Sbjct: 246 EGQFSSDDGTELIRLASRCLQYEPRERPNPK 276 >6EQI-C nrPDB Length = 433 Score = 92.6 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 57/357 (15%), Positives = 103/357 (28%), Gaps = 112/357 (31%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTG-----VYVALKEVK----LDSEEGTPSTAIRE-- 53 + E + G A VY K +A+K + + RE Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 54 -------------ISLMKELK-----HENIVRLYDVIHTENK------------------ 77 I + + K H NIVR+Y V Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 78 ---------LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 L LV + D LK+Y+ +T L L+ + + +A + + Sbjct: 135 PEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLL-------EAVAHMNIHN 187 Query: 129 ILHRDLKPQNLLINKRG-----QLKLGDFGLA---RAFGIPVNTFS---SEVVTLWYRAP 177 I HRDLK N+L++ + + DFG + G+ + S + AP Sbjct: 188 ISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAP 247 Query: 178 DVLMGS-RTYS----TSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESL 232 ++ T+S D+W+ G I E+ F Sbjct: 248 EIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKT------------------- 288 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK 289 + + ++ P + + + + + +L + + RL Sbjct: 289 --------------MKLLSKSYKEEDLPELPDTIPFIIRNLVSNMLSRSTNKRLDCD 331 >4IX6-A nrPDB Length = 350 Score = 90.3 bits (223), Expect = 9e-19, Method: Composition-based stats. Identities = 66/331 (19%), Positives = 108/331 (32%), Gaps = 66/331 (19%) Query: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN----IVRL 68 LG+G + TV++G+ K V LK K D E+ + + H N R Sbjct: 28 LGSGNFGTVFRGVFKGD-QDVVLKNAKADVM-AAEELLECEMDVNYHV-HANAKGTCARF 84 Query: 69 YDVIH----TENKLT--LVFE---FM-----DNDLKKYMDS-----RTVGNTPRGLELNL 109 I ++ + E M +N ++ M T EL + Sbjct: 85 MGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATELGV 144 Query: 110 VKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKR--GQLKLGDFGLARAFGIPVNTFSS 167 K +LL LA HE ++HRD+KP NL+ ++ G LKL D G A T + Sbjct: 145 TKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETLNY 204 Query: 168 EVV----TLWYR-APDVLMGSRTYSTSI----------------DIWSCGCILAEMITGK 206 Y A ++ + D WS GC++ ++ Sbjct: 205 YPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLA--- 261 Query: 207 PLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPL 266 + + + + K Y+ N + + + Sbjct: 262 --------------VVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDAN 307 Query: 267 DGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 G D L++ D R S + AL H +F Sbjct: 308 GGAGWDLCQRLMEAERDARASCEAALSHAFF 338 >5UU1-A nrPDB Length = 324 Score = 88.4 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 43/235 (18%), Positives = 84/235 (35%), Gaps = 37/235 (15%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 +Q+ +K+G+G + +Y A VK++ +E P E+ + + + Sbjct: 15 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGP--LFSELKFYQRVAKK 72 Query: 64 NIVR---------------LYDV----IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRG 104 + ++ Y + +V E + DL+K + Sbjct: 73 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQK------ISGQNGT 126 Query: 105 LELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLIN--KRGQLKLGDFGLA------- 155 + + V ++L L + HEN+ +H D+K NLL+ Q+ L D+GL+ Sbjct: 127 FKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNG 186 Query: 156 RAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFP 210 N T+ + + D G S D+ G + + GK + Sbjct: 187 NHKQYQENPRKGHNGTIEFTSLDAHKGV-ALSRRSDVEILGYCMLRWLCGKLPWE 240 >5CLR-A nrPDB Length = 451 Score = 87.2 bits (215), Expect = 8e-18, Method: Composition-based stats. Identities = 50/255 (19%), Positives = 88/255 (34%), Gaps = 29/255 (11%) Query: 22 YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENK--LT 79 +K G LK VK+D+E T E + +L RL E Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLT--EFTNEKDTLSKLG-----RLVGTFFNEQTQVHY 148 Query: 80 LVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQN 138 ++ F+ DL +Y ++ + + V + + HE ++HRDLKP N Sbjct: 149 ILTTFIKGIDLSRYKNALPLNVNLKHF--WEVLGIMISVCHQVKQFHELGLIHRDLKPGN 206 Query: 139 LLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV--LMGSRTYSTSIDIWSCG 196 ++++ Q L DFG + + P + T Y AP++ +S D+++ Sbjct: 207 IMLDADMQCHLVDFGSSSSDKEPK---PASWGTASYLAPELNAQEDFIAFSQVSDLFALA 263 Query: 197 CILAEMITGKPLFP---------GTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQ 247 L E+ F G ++ + L +I + + Y I Sbjct: 264 YSLDELFN---PFRQVKFAKVDIGIKNKHLVLLHAEIEACITGLMSNETSVRTLYFSRIL 320 Query: 248 QRPPRDLRQVLQPHT 262 Q +P Sbjct: 321 QLQRVPESFKSRPEA 335 >4O1O-A nrPDB Length = 717 Score = 79.9 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 49/289 (16%), Positives = 95/289 (32%), Gaps = 78/289 (26%) Query: 19 ATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HENIVRLYDVIHTENK 77 +Y GL + VA+K S G E+S ++ + ++N+V Y + Sbjct: 360 GGIYLGLYED--QEVAVKRFSEGSTRGQQ-----EVSCLQSSRANDNVVTFYGSESDGSC 412 Query: 78 LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQ 137 L + + L++++ + P + + + L + + H + H+DL+PQ Sbjct: 413 LHVCLALCEYTLQEHLANHRGDAVPNEEDES-ARNILSSLFKAIGELHRSGYSHQDLQPQ 471 Query: 138 NLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCG- 196 N+LI+ + L DF + + D+ + G Sbjct: 472 NILIDSKNGTFLADFDKSIKWAEDPQKIKR-----------------------DLEALGL 508 Query: 197 CILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQ 256 +L + G F ++ ++I G+P+E Sbjct: 509 LVLYVVKKGDISFETLKNQSFEEVIQ---GSPDEET------------------------ 541 Query: 257 VLQPHTKEPLDGNLMDFLHGLLQL--NPDMRLSAKQALHHPWFAEYYHH 303 D +H L N + RLS+ L HP+F + Sbjct: 542 --------------RDLIHHLFHPGDNVEDRLSS--LLAHPFFWSWESR 574 >2RSV-A nrPDB Length = 403 Score = 79.5 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 53/309 (17%), Positives = 111/309 (35%), Gaps = 44/309 (14%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYV------ALKE-----------VKLDSEEG 45 + ++K +G G + +Y + + V +K +K Sbjct: 40 AKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 98 Query: 46 TPSTAIREISLMKELKHENIVRLYDVIHTEN----KLTLVFEFMDNDLKKYMDSRTVGNT 101 P + I ++LK+ + + + + ++ + +DL+K ++ Sbjct: 99 KPEQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEAN----- 152 Query: 102 PRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLIN--KRGQLKLGDFGLA---- 155 + V ++L L + HE++ +H D+K NLL+N Q+ L D+GLA Sbjct: 153 AKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYC 212 Query: 156 -----RAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFP 210 + + T+ + + D G S D+ G + + +TG + Sbjct: 213 PEGVHKEYKEDPKRCHD--GTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPW- 268 Query: 211 GTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNL 270 ++ + K + D E++ + K + L +T++PL NL Sbjct: 269 -EDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 327 Query: 271 MDFLHGLLQ 279 D L L+ Sbjct: 328 RDILLQGLK 336 >2LAV-A nrPDB Length = 361 Score = 78.0 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 53/309 (17%), Positives = 111/309 (35%), Gaps = 44/309 (14%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYV------ALKE-----------VKLDSEEG 45 + ++K +G G + +Y + + V +K +K Sbjct: 33 AKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAA 91 Query: 46 TPSTAIREISLMKELKHENIVRLYDVIHTEN----KLTLVFEFMDNDLKKYMDSRTVGNT 101 P + I ++LK+ + + + + ++ + +DL+K ++ Sbjct: 92 KPEQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEAN----- 145 Query: 102 PRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLIN--KRGQLKLGDFGLA---- 155 + V ++L L + HE++ +H D+K NLL+N Q+ L D+GLA Sbjct: 146 AKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYC 205 Query: 156 -----RAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFP 210 + + T+ + + D G S D+ G + + +TG + Sbjct: 206 PEGVHKEYKEDPKRCHD--GTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPW- 261 Query: 211 GTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNL 270 ++ + K + D E++ + K + L +T++PL NL Sbjct: 262 -EDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 320 Query: 271 MDFLHGLLQ 279 D L L+ Sbjct: 321 RDILLQGLK 329 >4CI6-B nrPDB Length = 643 Score = 74.9 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 53/288 (18%), Positives = 107/288 (37%), Gaps = 47/288 (16%) Query: 27 KTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL-----KHENIVRLYD--VIHTENKLT 79 K VA K + +E E+ K + KH N+ ++ V+ N+ Sbjct: 66 KDKQRLVA-KIERSIAE----GHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYY 120 Query: 80 --LVFEFMDN-----DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHR 132 L+ + +D L+ DS G +K+ +LL + I+H Sbjct: 121 YALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHN 180 Query: 133 DLKPQNLLINK-RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSID 191 D+KP N++ ++ G+ + D GL G F T ++AP++ +G+ S D Sbjct: 181 DIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGF-----TESFKAPELGVGNLGASEKSD 235 Query: 192 IWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPP 251 ++ +++ ++ G F + + + + I P + + P + P I Sbjct: 236 VF---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMDEN--GYPIHRPGIAGVET 290 Query: 252 RDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 R F+ +L ++ D R + +A H + ++ Sbjct: 291 AYTR-----------------FITDILGVSADSRPDSNEARLHEFLSD 321 >6EAS-A nrPDB Length = 308 Score = 73.8 bits (180), Expect = 8e-14, Method: Composition-based stats. Identities = 41/259 (15%), Positives = 84/259 (32%), Gaps = 47/259 (18%) Query: 40 LDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTENKL--TLVFEFMDND-LKKYMDSR 96 D + S ++I+ + ++ H+N + L E+ +VFE+ N L +++ R Sbjct: 78 KDWSKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLHVR 137 Query: 97 TVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI--LHRDLKPQNLLINKRGQLKLGDFGL 154 L+ + L H+ + R+ + + K+ D Sbjct: 138 EA----EKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEF 193 Query: 155 ARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTND 214 +T ++E+ +PD+ R Y G +L E++TG+ + Sbjct: 194 WNDAKGHNSTTNNELA----FSPDMEDIVRKY---------GMVLLEILTGRVPSSEDDG 240 Query: 215 --EEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMD 272 E + F+ E + PS+ P E L + Sbjct: 241 PLENWVSRYFEGGMRLEELIDPSIGFFP-----------------------EDTARALCE 277 Query: 273 FLHGLLQLNPDMRLSAKQA 291 + + +P R K+ Sbjct: 278 VVRSCIDRDPKKRPQMKEV 296 >4OAU-C nrPDB Length = 699 Score = 73.0 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 31/136 (22%), Positives = 55/136 (40%), Gaps = 10/136 (7%) Query: 19 ATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HENIVRLYDVIHTENK 77 +Y G + VA+K EG+P A RE+S ++ + + ++V Y Sbjct: 357 GGIYLGFYE--KQEVAVKTF----CEGSPR-AQREVSCLQSSRENSHLVTFYGSESHRGH 409 Query: 78 LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH-ENKILHRDLKP 136 L + + L+ +D G E + + + + H H+DL+P Sbjct: 410 LFVCVTLCEQTLEACLDVHR-GEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQP 468 Query: 137 QNLLINKRGQLKLGDF 152 QN+LI+ + L DF Sbjct: 469 QNILIDSKKAAHLADF 484 >5DMZ-A nrPDB Length = 365 Score = 68.7 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 57/307 (18%), Positives = 108/307 (35%), Gaps = 39/307 (12%) Query: 5 SQFKQLEKL-------GNGTYATVYKGL-----NKTTGVYVALKEVKLDSEEGTPSTAIR 52 ++F+ KL G G +A VY+ + LK + P Sbjct: 58 TEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKV----QKPANPWEFYI 113 Query: 53 EISLMKELK----HENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLEL 107 LM+ LK H ++ Y +N LV E L ++ + + Sbjct: 114 GTQLMERLKPSMQHMF-MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYK-NTPEKVMPQ 171 Query: 108 NLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQ-----------LKLGDFGLAR 156 LV F ++L + H+ +I+H D+KP N ++ L L D G + Sbjct: 172 GLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSI 231 Query: 157 AFGI--PVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTND 214 + F+++ T ++ ++L + ++ ID + + M+ G N+ Sbjct: 232 DMKLFPKGTIFTAKCETSGFQCVEMLSN-KPWNYQIDYFGVAATVYCMLFGTY-MKVKNE 289 Query: 215 EEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRD-LRQVLQPHTKEPLDGNLMDF 273 + K P+ +W + P+ P D LRQ L+ ++ + Sbjct: 290 GGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRAL 349 Query: 274 LHGLLQL 280 + L+ L Sbjct: 350 RNRLIVL 356 >6G4J-A nrPDB Length = 315 Score = 66.8 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 40/234 (17%), Positives = 83/234 (35%), Gaps = 34/234 (14%) Query: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKH 62 + + + ++LG G VY T+ +VALK + E++++K Sbjct: 24 NGNTYTLRKQLGKGANGIVYLAE--TSDGHVALKV------SDDSLSITSEVNVLKSFSK 75 Query: 63 ENIVRLYDVIHTENKLTL----------VFEFMDN-DLKKYMDSRTVGNTPRGLELNLVK 111 V + + + E++ L KY+ + + Sbjct: 76 AQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGA---------EWIP 126 Query: 112 YFQWQLLQGLAFCHENKILHRDLKPQNLLINK-RGQLKLGDFGLARAFGIPVNTFSSEVV 170 QLL L+ H+ + DLKP NL++ +++ D G G + ++ Sbjct: 127 VLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYD 186 Query: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDI 224 ++ G+R S D+++ I+ + K +EQL+ + + Sbjct: 187 RGYWG-----YGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIEG 235 >5GZ9-A nrPDB Length = 305 Score = 64.9 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 27/213 (12%), Positives = 65/213 (30%), Gaps = 32/213 (15%) Query: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 ++ +QL+++G G V+ K VA + + + + ++K L+ E+ Sbjct: 34 TEVRQLKRVGEGAVKRVFLSEWKE--HKVA---LSRLTRLEMKEDFLHGLQMLKSLQSEH 88 Query: 65 IVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 +V L + ++ E+ L ++ + + + + + Sbjct: 89 VVTLVGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINY 146 Query: 124 CHENKILHRDLKPQN--------LLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW-- 173 H + + R + N L+ + D + Sbjct: 147 LHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLI-KCGHRELH 205 Query: 174 --YRAPDVLMGSR-----------TYSTSIDIW 193 + AP+ L +Y+ +DIW Sbjct: 206 GDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >5GZA-A nrPDB Length = 290 Score = 64.9 bits (157), Expect = 5e-11, Method: Composition-based stats. Identities = 32/214 (14%), Positives = 63/214 (29%), Gaps = 41/214 (19%) Query: 8 KQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVR 67 ++++ +G G VY + G VA + + S + + +S+++ L+ ++V Sbjct: 28 RRVKLIGQGAVKKVYLSEWQ--GQKVA---LSVLSSDQYADDFLHGLSMLRALQSSHVVT 82 Query: 68 LYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 L V + V E+ + + + + LA+ H Sbjct: 83 LVGVCEED--AVFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHS 140 Query: 127 NKILHRDLKPQN--------LLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-------- 170 + R + N L+ +L LA + Sbjct: 141 SPAGIRVMCDSNDLHKTLSQFLLASDMRL------LANDLDALPEVEKGGLGVKCGHHEL 194 Query: 171 TLWYRAPDVL-----------MGSRTYSTSIDIW 193 T + AP+ L Y DIW Sbjct: 195 TGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >2JII-A nrPDB Length = 352 Score = 63.4 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 39/228 (17%), Positives = 79/228 (34%), Gaps = 26/228 (11%) Query: 72 IHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 +H + LV L + + S + L V +LL L F HEN+ +H Sbjct: 127 VHQDKYRFLVLP----SLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVH 182 Query: 132 RDLKPQNLLIN--KRGQLKLGDFGLARAFGIPVNTFSSEVVTL-------WYRAPDVLMG 182 ++ +N+ ++ + Q+ L +G A + + + + + D+ G Sbjct: 183 GNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKG 242 Query: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGT--NDEEQLKLIFDIMGTPNESLWPSVTKLP 240 S D+ S G + + + G + N E+ +K + P + P Sbjct: 243 CGP-SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGP----CG 297 Query: 241 KYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQ------LNP 282 + + + + ++P L + L LLQ +P Sbjct: 298 HWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDP 345 >4CYJ-A nrPDB Length = 438 Score = 58.3 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 27/139 (19%), Positives = 58/139 (41%), Gaps = 10/139 (7%) Query: 21 VYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTE--NKL 78 VYK N G + AL+ ++ + + K++K+ +IV +++V T Sbjct: 71 VYKAQNSRNGRHYALRRLE-GYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTTREFGDS 129 Query: 79 TLVFEFMDNDLKKYMDSRTV-------GNTPRGLELNLVKYFQWQLLQGLAFCHENKILH 131 +L+F + + L K + P + N + + Q+ L H N++ Sbjct: 130 SLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSNRLAA 189 Query: 132 RDLKPQNLLINKRGQLKLG 150 R L+P +++ +++L Sbjct: 190 RCLEPSKIILTDINRIRLS 208 >6R5K-O nrPDB Length = 689 Score = 56.8 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 54/137 (39%), Gaps = 7/137 (5%) Query: 20 TVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTEN--- 76 T++K + G LK + + P+ + + ++ N+++ D+ T Sbjct: 309 TLFKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGD 368 Query: 77 -KLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRD-L 134 + LVF++ N L Y D V + N + + QL + H + + L Sbjct: 369 LSICLVFDYYPNSLSLY-DYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTL 427 Query: 135 KPQNLLINKR-GQLKLG 150 + +LI G++KL Sbjct: 428 NWRKVLITGDPGRIKLS 444 >6EWX-A nrPDB Length = 484 Score = 56.8 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 39/239 (16%), Positives = 68/239 (28%), Gaps = 76/239 (31%) Query: 94 DSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRG-------- 145 DS + V + QL GL E+ I+HRDL +NLL+ Sbjct: 196 DSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPS 255 Query: 146 ---------------------------------QLKLGDFGLARAFGIPVNTFSSEVVTL 172 +L + +F A+ + Sbjct: 256 ANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQA 315 Query: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESL 232 AP+++ S+ D + G ++ E++ F E + + Sbjct: 316 R-LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPF------EVRAQLRE--RDYRRED 364 Query: 233 WPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291 P + L Y+P +QQ H LL+ +P R+ +A Sbjct: 365 LPPLPTLSLYSPGLQQ------------------------LAHLLLEADPIKRIRIGEA 399 >6M7Z-A nrPDB Length = 319 Score = 55.7 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 26/207 (12%), Positives = 59/207 (28%), Gaps = 61/207 (29%) Query: 104 GLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN 163 G V+ ++ L H +LHR ++ + + G + LG A G Sbjct: 140 GRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLGGLDTAAPIGTETR 199 Query: 164 TFSSEVVTLWYRAPDV--------LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDE 215 + AP++ + ++ D++S G Sbjct: 200 LWVGFFGQE--TAPEIDRNFLADLALTQGRHTVKSDVYSLGV------------------ 239 Query: 216 EQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLH 275 + + ++G N L P + + + ++ L Sbjct: 240 -AFRNLVQLLGNGN----------------------------LGPEDRGAVRQDHLELLD 270 Query: 276 ----GLLQLNPDMRLSAKQALHHPWFA 298 +++ P R + ++ + P F Sbjct: 271 KLSQKMIEEEPGNRPTIEEIMKDPLFE 297 >4BWP-A nrPDB Length = 448 Score = 55.3 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 30/164 (18%), Positives = 57/164 (34%), Gaps = 36/164 (21%) Query: 22 YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHT----ENK 77 Y+ + TTG L+ + + T + + + K+L+H N+V+L +V T +N Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTL--VEMWKKLQHTNVVQLREVFTTKAFGDNS 124 Query: 78 LTLVFEFMDND---LKKYM-----------------------DSRTVGNTPRGLELNLVK 111 L LV+++ L KY + + L + Sbjct: 125 LVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIW 184 Query: 112 YFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQ----LKLGD 151 QL GL H + + L P +++ + + D Sbjct: 185 SIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >4XR7-L nrPDB Length = 465 Score = 55.3 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 26/135 (19%), Positives = 52/135 (38%), Gaps = 7/135 (5%) Query: 22 YKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTEN----K 77 +K + G LK + + P+ + + ++ N+++ D+ T Sbjct: 87 FKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDLS 146 Query: 78 LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRD-LKP 136 + LVF++ N L Y D V + N + + QL + H + + L Sbjct: 147 ICLVFDYYPNSLSLY-DYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLNW 205 Query: 137 QNLLINKR-GQLKLG 150 + +LI G++KL Sbjct: 206 RKVLITGDPGRIKLS 220 >4AZW-A nrPDB Length = 471 Score = 53.7 bits (128), Expect = 8e-08, Method: Composition-based stats. Identities = 21/121 (17%), Positives = 39/121 (32%), Gaps = 15/121 (12%) Query: 37 EVKLDSEEGTPSTAIREISLMKE----LKHENIVRLYDVIHTENKLTLVFEFMDNDLKKY 92 + + + EI + + + LV E + L Sbjct: 275 ILTAEESQRNKHELHNEIKFLTQPPAGFDAPAV---LAHGENAQSGWLVMEKLPGRLLSD 331 Query: 93 MDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDF 152 M + E + LL+ LA + H D++P N++++ R +L DF Sbjct: 332 MLAAG--------EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDF 383 Query: 153 G 153 G Sbjct: 384 G 384 >4AZV-A nrPDB Length = 569 Score = 53.0 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 21/121 (17%), Positives = 39/121 (32%), Gaps = 15/121 (12%) Query: 37 EVKLDSEEGTPSTAIREISLMKE----LKHENIVRLYDVIHTENKLTLVFEFMDNDLKKY 92 + + + EI + + + LV E + L Sbjct: 275 ILTAEESQRNKYELHNEIKFLTQPPAGFDAPAV---LAHGENAQSGWLVMEKLPGRLLSD 331 Query: 93 MDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDF 152 M + E + LL+ LA + H D++P N++++ R +L DF Sbjct: 332 MLAAG--------EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDF 383 Query: 153 G 153 G Sbjct: 384 G 384 >6BHC-A nrPDB Length = 438 Score = 51.4 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 50/304 (16%), Positives = 93/304 (30%), Gaps = 88/304 (28%) Query: 33 VALKEVK---LDSEEGTPSTAIRE-----ISLMKELKH-----EN-IVRLYD-------- 70 A+K K +S++ S A+R+ ++ ++ H N ++ D Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPSKKQRSH 145 Query: 71 --VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 VI E V +F+ + L ++ L V QL GL Sbjct: 146 VVVITREVPCLTVADFVRDSLAQH-------GKSPDLYERQVCLLLLQLCSGLEHLKPYH 198 Query: 129 ILHRDLKPQNLLI---------------------NKRGQLKLGDFGLARAFGIPVNTFSS 167 + H DL+ +NLL+ + +L + +F A+ V+ Sbjct: 199 VTHCDLRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEIL 258 Query: 168 EVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGT 227 + AP+++ ++ D + G ++ EM+ F Sbjct: 259 RDQSR--LAPEIITATQY--KKCDEFQTGILIYEMLHLPNPF------------------ 296 Query: 228 PNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLS 287 P + + ++ + P R P L LL NP R+ Sbjct: 297 ---DENPELKEREYTRADLPRIPFRS-----------PYSRGLQQLASCLLNPNPSERIL 342 Query: 288 AKQA 291 A Sbjct: 343 ISDA 346 >5VE6-A nrPDB Length = 492 Score = 49.5 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 14/35 (40%), Positives = 19/35 (54%) Query: 107 LNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLI 141 V + QL GL E+ I+HRDL +NLL+ Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 >3ENH-A nrPDB Length = 540 Score = 48.3 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 29/170 (17%), Positives = 59/170 (34%), Gaps = 34/170 (20%) Query: 13 LGNGTYATVYKGLNKTTGVYVALK-EVKLDSEEGT------PSTAIREISLMKELKH--- 62 +G G A + + V +K VK + S RE + +K Sbjct: 344 IGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGI 401 Query: 63 --ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQG 120 I +DV ++ +++ L K + + +++ + Sbjct: 402 PAPYI---FDVDLDNKRIM--MSYINGKLAKDV-------------IEDNLDIAYKIGEI 443 Query: 121 LAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV 170 + H+N ++H DL N + +K L + DFGL + + + +V Sbjct: 444 VGKLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDEDKAVDLIV 491 >3Q60-A nrPDB Length = 371 Score = 46.8 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 54/337 (16%), Positives = 102/337 (30%), Gaps = 72/337 (21%) Query: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPS-TAIREISLMKELKHEN 64 + K +E L G + V+ + ALK + +E + E + Sbjct: 63 KLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAA------ 116 Query: 65 IVRLYD-------------------VIHTENKL---------------TLVFEFMDNDLK 90 RL + ++ L+ DL+ Sbjct: 117 -ARLLGESPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLE 175 Query: 91 KYMDSRTVGNTPRGLELNLVKYFQ-WQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKL 149 + RG E L + QL++ A ++H P NL I G+L L Sbjct: 176 LLFSTLDFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLML 235 Query: 150 GDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR-TYSTSIDIWSCGCILAEMITGKPL 208 GD ++ + + +S V + Y + L S T++ +++ W G + + Sbjct: 236 GD--VSALWKVGTRGPASSV-PVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLP 292 Query: 209 FPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDG 268 F + P + K P+++ L + PL Sbjct: 293 F--------------------GLVTPGIKGSWK-RPSLR----VPGTDSLAFGSCTPLPD 327 Query: 269 NLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHAS 305 + + L + RL +A+ P F + + S Sbjct: 328 FVKTLIGRFLNFDRRRRLLPLEAMETPEFLQLQNEIS 364 >6G38-A nrPDB Length = 357 Score = 46.8 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 35/183 (19%), Positives = 61/183 (33%), Gaps = 55/183 (30%) Query: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD-------SEEGTPSTAIREISL 56 + + ++ EK+G G + V++ + T VA+K + ++ S + T + EI + Sbjct: 40 TEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQKTFEEILPEIII 97 Query: 57 MKE-----------------LKHENIVR------LYDV----------------IHTENK 77 KE L + V+ L +++ Sbjct: 98 SKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQ 157 Query: 78 LTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH-ENKILHRDLKP 136 L +V EF + RT + L K QL LA + HRDL Sbjct: 158 LFIVLEFEFGGI-DLEQMRTKLS-----SLATAKSILHQLTASLAVAEASLRFEHRDLHW 211 Query: 137 QNL 139 N+ Sbjct: 212 GNV 214 >3BYV-A nrPDB Length = 377 Score = 45.3 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 21/120 (17%), Positives = 47/120 (39%), Gaps = 14/120 (11%) Query: 99 GNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF 158 +T + L + Q+++ LA H ++H L+P ++++++RG + L F Sbjct: 197 SSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF----EH 252 Query: 159 GIPVNTFSSEVVTLWYRAPDV---------LMGSRTY-STSIDIWSCGCILAEMITGKPL 208 + V+ + P++ RT + S D W+ G ++ + Sbjct: 253 LVRDGARVVSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLP 312 >4WWA-A nrPDB Length = 261 Score = 44.9 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 30/158 (18%), Positives = 51/158 (32%), Gaps = 35/158 (22%) Query: 22 YKGLNKTTGVYVALK-------EVKLDSEEGTPSTAIREISLMKELKHENIV------RL 68 Y K + +K + T + E L+ +L ++ +L Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKL---YLIPGLCVPQL 94 Query: 69 YDVIHTENKLTLVFEFMDNDL---------KKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 + L EF+ DL K ++ + L ++ Q+ Sbjct: 95 IACDPYNGFIWL--EFLGEDLPGGHGFSNLKNFLWMHDQ-DPYSDLVATTLRKVGRQI-- 149 Query: 120 GLAFCHENKILHRDLKPQNLLINKRG---QLKLGDFGL 154 GL H N H DL N+++ + G L DFGL Sbjct: 150 GL--LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >4CZY-B nrPDB Length = 429 Score = 44.9 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 29/141 (20%), Positives = 58/141 (41%), Gaps = 16/141 (11%) Query: 22 YKGLNKTTGVYVALKEVK--LDSEEGTPSTAIREISLMKELKHENIVRLYDVIHTE---- 75 YK N G + AL+ ++ + E +E K++ + NIV +++ TE Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKE---WKKIINANIVTVHEAFTTEFFGD 117 Query: 76 NKLTLVFEF--MDNDLKKYM----DSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKI 129 + L V++F + L + +S + NL+ + Q+ L H K+ Sbjct: 118 SSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKL 177 Query: 130 LHRDLKPQNLLINKRGQLKLG 150 R L+ + I + +++L Sbjct: 178 AARCLELSKI-IWENNRIRLA 197 >2W1Z-A nrPDB Length = 368 Score = 43.7 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 31/192 (16%), Positives = 68/192 (35%), Gaps = 13/192 (6%) Query: 87 NDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQ 146 + L + S +T + L + QL++ A ++H D + +N+L+++RG Sbjct: 172 HILGDVLLSH--SSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGG 229 Query: 147 LKLGDFG-LARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTY-----STSIDIWSCGCILA 200 + L F L R V+ A + ++ R + + D W+ G + Sbjct: 230 VFLTGFEHLVRDGASAVSPIGRGFAPPETTA-ERMLPYRQHHPTLMTFPFDTWTLGLAIY 288 Query: 201 EMITGKPLFPGTNDEEQ--LKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVL 258 + T D E ++ I+ + + + +Y+ + P + + Sbjct: 289 WIWCADLP--NTEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYSKEDRLLPLQAMETSE 346 Query: 259 QPHTKEPLDGNL 270 + L L Sbjct: 347 YEQLRTELSAVL 358 >3DZO-A nrPDB Length = 413 Score = 42.6 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 34/221 (15%), Positives = 80/221 (36%), Gaps = 35/221 (15%) Query: 23 KGLNKTTGVYV--------------ALKEVKLD----------SEEGTPSTAIREISLMK 58 + ++ TG A+K++K + + +R I Sbjct: 96 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 155 Query: 59 ELKHENIVRLYDVIHTENKLTLVFEF-----MDNDLKKYMD-SRTVGNTPRGLELNLVKY 112 +K ++ V E + ++ F M ++L+ + + + +T + L + Sbjct: 156 LVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQ 215 Query: 113 FQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFG-LARAFGIPVNTFSSEVVT 171 Q+++ LA H ++H L+P ++++++RG + L F L R V+ Sbjct: 216 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGFEHLVRDGASAVSPIGRGFAP 275 Query: 172 LWYRAPDVLMGSRTY----STSIDIWSCGCILAEMITGKPL 208 A +L + + + + D W+ G + + Sbjct: 276 PETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLP 316 >1TQM-A nrPDB Length = 282 Score = 39.5 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 32/160 (20%), Positives = 63/160 (39%), Gaps = 33/160 (20%) Query: 9 QLEKLGNGTYATVYKGLNKTTGVYVAL---------KEVKLDSEEGTP-------STAIR 52 + +G G + V+ ++ G V K+VK + G +A Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 53 EISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKY 112 E +++L+ + ++Y E L E +D K + V N L++ Sbjct: 154 EFRALQKLQGLAVPKVYAW---EGNAVL-MELID---AKELYRVRVENPDEVLDM----- 201 Query: 113 FQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDF 152 +L+ +A + I+H DL N+L+++ G + + DF Sbjct: 202 ----ILEEVAKFYHRGIVHGDLSQYNVLVSEEG-IWIIDF 236 >5YK0-A nrPDB Length = 452 Score = 39.1 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 26/181 (14%), Positives = 54/181 (29%), Gaps = 61/181 (33%) Query: 19 ATVYKGLNKTTGVYVALKEVKLDSEEGTP---STAIREISLMKEL--------------- 60 V+K + + G VA+K ++E T R + ++K+L Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 61 -----------------------KHE-----NIVRLYDVIHTENKLTLVFEFMDNDLKKY 92 H ++V ++ E+++ Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVV-------ASAPKVVIQEWIEGVPMAE 257 Query: 93 MDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDF 152 + R L L+ + + L ++H D P N ++ G++ + DF Sbjct: 258 IIRHG-TTEQRDLIGTLLAELTFDAPRRL------GLMHGDAHPGNFMLLPDGRMGIIDF 310 Query: 153 G 153 G Sbjct: 311 G 311 >6G18-v nrPDB Length = 552 Score = 36.4 bits (83), Expect = 0.014, Method: Composition-based stats. Identities = 10/79 (12%), Positives = 27/79 (34%), Gaps = 11/79 (13%) Query: 74 TENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRD 133 N+ +V E ++ V + + + + + ++H D Sbjct: 180 DYNRHAVVMELING--YPLCQIHHVEDPASVYDEAMELIVK---------LANHGLIHGD 228 Query: 134 LKPQNLLINKRGQLKLGDF 152 NL++++ + + DF Sbjct: 229 FNEFNLILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 35.2 bits (80), Expect = 0.036, Method: Composition-based stats. Identities = 10/79 (12%), Positives = 27/79 (34%), Gaps = 11/79 (13%) Query: 74 TENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRD 133 N+ +V E ++ V + + + + + ++H D Sbjct: 180 DYNRHAVVMELING--YPLCQIHHVEDPASVYDEAMELIVK---------LANHGLIHGD 228 Query: 134 LKPQNLLINKRGQLKLGDF 152 NL++++ + + DF Sbjct: 229 FNEFNLILDESDHITMIDF 247 >6BQ8-A nrPDB Length = 152 Score = 32.2 bits (72), Expect = 0.32, Method: Composition-based stats. Identities = 19/137 (13%), Positives = 49/137 (35%), Gaps = 16/137 (11%) Query: 41 DSEEGTPSTAIREISLMKELKHENIVRLYDV----IHTENKLTLVFEFMDNDLKKYMDSR 96 + + +R +SL+K L + + ++ D + + ++ E + ++ ++ Sbjct: 5 QARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGD-YIIREGEEGSTF-FILAK 62 Query: 97 TVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLAR 156 + E + L +G + E ++ D++ N++ + L Sbjct: 63 GKVKVTQSTEGHDQPQLIKTLQKG-EYFGEKALISDDVRSANIIAEENDVACLV------ 115 Query: 157 AFGIPVNTFSSEVVTLW 173 I TF+ V T Sbjct: 116 ---IDRETFNQTVGTFE 129 >6FAI-l nrPDB Length = 425 Score = 31.4 bits (70), Expect = 0.50, Method: Composition-based stats. Identities = 21/180 (11%), Positives = 52/180 (28%), Gaps = 42/180 (23%) Query: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE----------------- 43 ++ + + +G G + +YK +K V +K +L Sbjct: 89 LNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQ 147 Query: 44 -----EGTPSTAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTV 98 + A +E M L + ++ + + +V E ++ + + Sbjct: 148 GANWMHLSRLAANKEYQFMSMLYSKGF-KVPEPFDNSRHI-VVMELIEGYPMRRLRKHKN 205 Query: 99 GNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINK------RGQLKLGDF 152 + L+ + + ++H D N++I + DF Sbjct: 206 -----------IPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >4BVU-A nrPDB Length = 211 Score = 31.4 bits (70), Expect = 0.53, Method: Composition-based stats. Identities = 28/152 (18%), Positives = 54/152 (35%), Gaps = 30/152 (19%) Query: 9 QLEKLGNGTYATVYKGLNKTTGVYVALKE--VKLDSEEGTPSTAIREISLMKELKHENIV 66 + +G G+ A +++ +N ++ +Y K+ + + A +E L Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY---KKYDLIGNQYNEILEMAWQESELFN-------- 92 Query: 67 RLYD-----VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 Y VI + L + +D+ + + L L L+ Sbjct: 93 AFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICK--------- 143 Query: 122 AFCHENKILHRDLKPQNLLINKRGQ-LKLGDF 152 +E I+H DL N+L +K + L DF Sbjct: 144 --LNELSIIHYDLNTGNMLYDKESESLFPIDF 173 >5JY7-I nrPDB Length = 441 Score = 30.6 bits (68), Expect = 0.97, Method: Composition-based stats. Identities = 15/77 (19%), Positives = 27/77 (35%), Gaps = 11/77 (14%) Query: 21 VYKGLNKTTGVYV---ALKEVKLDSEEGTPSTAIREI-SLMKELKHENIVRLYDVIHTEN 76 V+ T V A+ ++ G E+ ++ + ++ RL TE Sbjct: 126 VFGAEQSNTSVVFGEDAIFKLFRRITPGVHPDI--ELNRVLARAGNPHVARLLGSFETEW 183 Query: 77 K-----LTLVFEFMDND 88 + L +V EF N Sbjct: 184 EGEPYALGMVTEFAANS 200 >5L3X-B nrPDB Length = 405 Score = 30.2 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 21/69 (30%), Positives = 33/69 (47%), Gaps = 3/69 (4%) Query: 50 AIREISLMKELKHENIVRLY-DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELN 108 + EIS +L H +++L + TE+ V E ++ LKK + R V RG L Sbjct: 269 LLDEISTCHQLLHPQVLQLLVKLFETEHSALDVMEQLE--LKKTLLDRMVHLLSRGYVLP 326 Query: 109 LVKYFQWQL 117 +V Y + L Sbjct: 327 VVSYIRKCL 335 >6GML-W nrPDB Length = 584 Score = 30.2 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 21/69 (30%), Positives = 33/69 (47%), Gaps = 3/69 (4%) Query: 50 AIREISLMKELKHENIVRLY-DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELN 108 + EIS +L H +++L + TE+ V E ++ LKK + R V RG L Sbjct: 448 LLDEISTCHQLLHPQVLQLLVKLFETEHSQLDVMEQLE--LKKTLLDRMVHLLSRGYVLP 505 Query: 109 LVKYFQWQL 117 +V Y + L Sbjct: 506 VVSYIRKCL 514 >1ZUN-A nrPDB Length = 325 Score = 29.8 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 16/100 (16%), Positives = 32/100 (32%), Gaps = 7/100 (7%) Query: 188 TSIDIWSCGCILAEMITGKP--LFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 T +DIW + G P + + ++ ++ +E + +T K Sbjct: 209 TELDIWQ-----YIYLEGIPIVPLYFAAERDVIEKNGTLIMIDDERILEHLTDEEKSRIV 263 Query: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMR 285 ++ R L E +L D + +L R Sbjct: 264 KKKVRFRTLGCYPLTGAVESEATSLTDIIQEMLLTRTSER 303 >6EF6-A nrPDB Length = 354 Score = 29.5 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 15/28 (53%), Gaps = 3/28 (10%) Query: 128 KILHRDLKPQNLLINKRG---QLKLGDF 152 ++H DL+ NLL++ + + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >2QG7-A nrPDB Length = 458 Score = 29.5 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 24/121 (19%), Positives = 43/121 (35%), Gaps = 33/121 (27%) Query: 29 TGVYVALKEVKLDSE---------EGTPSTAIREISLMKELKHENIVRLYDVIHTENKLT 79 T + + +K++ ++ RE + L ++NI + V T ++ Sbjct: 121 TNILIKVKDMSKQAKYLIRLYGPKTDEIINREREKKISCILYNKNIAKKIYVFFTNGRIE 180 Query: 80 LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKP-QN 138 EFMD Y SR P+ +L + + L H D+K +N Sbjct: 181 ---EFMDG----YALSREDIKNPKFQKL---------IAKNLKLLH-------DIKLNEN 217 Query: 139 L 139 L Sbjct: 218 L 218 >4H05-A nrPDB Length = 273 Score = 29.5 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 12/57 (21%), Positives = 21/57 (36%), Gaps = 9/57 (15%) Query: 88 DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKR 144 DL+ + R + R L + + + H DL P N+L++ R Sbjct: 154 DLEDLDEERKGWSGERLLAELERTRPADE---------DLAVCHGDLCPDNVLLDPR 201 >6MRG-A nrPDB Length = 580 Score = 29.1 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 10/48 (20%), Positives = 22/48 (45%), Gaps = 5/48 (10%) Query: 15 NGTYATVY-----KGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLM 57 G + ++ K + + G+ VA++ V L +E +RE+ + Sbjct: 525 KGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQL 572 >1OYZ-A nrPDB Length = 280 Score = 28.7 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 12/65 (18%), Positives = 27/65 (41%), Gaps = 5/65 (7%) Query: 86 DNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRG 145 D++L + +D + ++ Q + + FC + + RD+ +L G Sbjct: 25 DDELFRLLDDHNSLKRISSARVLQLRGGQDAVRLAIEFCSDKNYIRRDIGAF-IL----G 79 Query: 146 QLKLG 150 Q+K+ Sbjct: 80 QIKIC 84 >5LJ3-H nrPDB Length = 591 Score = 28.7 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 13/40 (32%), Positives = 20/40 (50%), Gaps = 1/40 (2%) Query: 131 HRDLKPQNLLINKRGQLK-LGDFGLARAFGIPVNTFSSEV 169 HRDL N+LI + K + DF L + G + S+ + Sbjct: 41 HRDLFQVNILIGRDIICKNVVDFTLNKQNGRLIPALSALI 80 >2X8T-A nrPDB Length = 471 Score = 28.7 bits (63), Expect = 3.5, Method: Composition-based stats. Identities = 7/22 (31%), Positives = 12/22 (54%) Query: 61 KHENIVRLYDVIHTENKLTLVF 82 KH N+V + + KL +V+ Sbjct: 165 KHPNVVDPHTFFDKDGKLWMVY 186 >3LV4-A nrPDB Length = 456 Score = 27.9 bits (61), Expect = 5.1, Method: Composition-based stats. Identities = 11/43 (25%), Positives = 17/43 (39%), Gaps = 1/43 (2%) Query: 61 KHENIVRLYDVIHTENKLTLVF-EFMDNDLKKYMDSRTVGNTP 102 KH N+V + KL +V+ + MD +T P Sbjct: 142 KHPNVVDPHTFFDQNGKLWMVYGSYSGGIFILEMDKKTGFPLP 184 >5FBM-A nrPDB Length = 99 Score = 27.9 bits (61), Expect = 5.9, Method: Composition-based stats. Identities = 10/43 (23%), Positives = 21/43 (48%), Gaps = 6/43 (13%) Query: 8 KQLEKLGNGTYATVY-----KGLNKTTGVYVALKEVKLDSEEG 45 ++++ +G G + V KG N TG + +K K+ + + Sbjct: 41 EKVQLIGFGNF-EVRERAARKGRNPQTGEEIKIKASKVPAFKA 82 >5AJ2-A nrPDB Length = 355 Score = 27.5 bits (60), Expect = 8.2, Method: Composition-based stats. Identities = 13/85 (15%), Positives = 29/85 (34%), Gaps = 9/85 (10%) Query: 202 MITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPH 261 ++ G F N E LI + N + + T+ ++ ++ L Sbjct: 246 LLDGYNEFHPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRHVGA---------LTAE 296 Query: 262 TKEPLDGNLMDFLHGLLQLNPDMRL 286 + + + D + +L + RL Sbjct: 297 VGDMTEDSAKDLIEAVLVPDQVERL 321 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.153 0.486 Lambda K H 0.267 0.0468 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,502,608 Number of Sequences: 36641 Number of extensions: 642807 Number of successful extensions: 5938 Number of sequences better than 10.0: 514 Number of HSP's better than 10.0 without gapping: 946 Number of HSP's successfully gapped in prelim test: 50 Number of HSP's that attempted gapping in prelim test: 1697 Number of HSP's gapped (non-prelim): 1341 length of query: 305 length of database: 10,336,785 effective HSP length: 97 effective length of query: 208 effective length of database: 6,782,608 effective search space: 1410782464 effective search space used: 1410782464 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 59 (27.1 bits)