BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P16892 (353 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2F9G-A nrPDB 736 0.0 5NGU-A nrPDB 354 3e-98 4QTB-A nrPDB 348 1e-96 6DTL-A nrPDB 341 4e-94 4ZSG-A nrPDB 333 5e-92 4IC8-A nrPDB 333 8e-92 5Z33-A nrPDB 330 7e-91 4EWQ-A nrPDB 313 5e-86 3OHT-A nrPDB 311 2e-85 3GC9-A nrPDB 306 1e-83 4QNY-A nrPDB 288 4e-78 4MYG-A nrPDB 279 1e-75 1CM8-A nrPDB 277 5e-75 3OZ6-A nrPDB 260 5e-70 4O2Z-A nrPDB 258 3e-69 3N9X-A nrPDB 233 1e-61 3RP9-A nrPDB 232 2e-61 1JNK-A nrPDB 229 1e-60 3E7O-A nrPDB 228 4e-60 3PG1-A nrPDB 226 1e-59 2XS0-A nrPDB 220 7e-58 3NIE-A nrPDB 219 2e-57 5AWM-A nrPDB 218 4e-57 3FI2-A nrPDB 216 2e-56 2I6L-A nrPDB 216 2e-56 6GU6-A nrPDB 194 5e-50 3NIZ-A nrPDB 191 3e-49 2BPM-A nrPDB 191 4e-49 1V0B-A nrPDB 190 6e-49 4AU8-A nrPDB 188 3e-48 4BGQ-A nrPDB 182 2e-46 4KRC-A nrPDB 181 3e-46 1G3N-A nrPDB 181 5e-46 1UA2-A nrPDB 179 1e-45 4NST-A nrPDB 177 5e-45 5EFQ-A nrPDB 177 6e-45 5G6V-A nrPDB 175 3e-44 4AGU-A nrPDB 173 9e-44 2W96-B nrPDB 169 1e-42 4BBM-A nrPDB 169 2e-42 3MIA-A nrPDB 163 1e-40 5AIR-A nrPDB 162 2e-40 3ZDU-A nrPDB 156 1e-38 3EB0-A nrPDB 152 2e-37 4E7W-A nrPDB 152 2e-37 3GC0-A nrPDB 149 2e-36 3E3P-A nrPDB 147 9e-36 5X8I-B nrPDB 134 7e-32 4CRL-A nrPDB 127 5e-30 2YCR-A nrPDB 127 5e-30 3I6U-A nrPDB 127 1e-29 5Y86-A nrPDB 126 1e-29 3NCG-A nrPDB 125 4e-29 3DFA-A nrPDB 124 5e-29 6FYV-A nrPDB 122 2e-28 5XVU-A nrPDB 120 1e-27 5ZTN-A nrPDB 119 2e-27 6O6Q-A nrPDB 117 1e-26 5JN2-A nrPDB 116 2e-26 6HMD-A nrPDB 115 3e-26 3MA6-A nrPDB 115 3e-26 3BHH-A nrPDB 113 1e-25 4MVF-A nrPDB 112 2e-25 2V7O-A nrPDB 112 2e-25 4RGJ-A nrPDB 112 3e-25 4JDH-A nrPDB 112 3e-25 2Q0N-A nrPDB 112 3e-25 4FIE-A nrPDB 112 3e-25 6EII-A nrPDB 111 4e-25 4XBR-A nrPDB 111 4e-25 2VN9-A nrPDB 110 7e-25 3LIJ-A nrPDB 110 8e-25 3HZT-A nrPDB 110 1e-24 3DXN-A nrPDB 110 1e-24 2JC6-A nrPDB 109 1e-24 4MD7-E nrPDB 109 2e-24 5FG8-A nrPDB 108 3e-24 2PVN-A nrPDB 108 4e-24 1PHK-A nrPDB 107 6e-24 4FG9-A nrPDB 107 7e-24 2JAM-A nrPDB 107 9e-24 4IAN-A nrPDB 107 9e-24 2F57-A nrPDB 106 2e-23 3H4J-B nrPDB 106 2e-23 3MN3-A nrPDB 106 2e-23 2VZ6-A nrPDB 105 2e-23 5U6Y-A nrPDB 105 3e-23 2Y7J-A nrPDB 104 5e-23 2BDW-A nrPDB 104 5e-23 5UNP-A nrPDB 104 5e-23 3KK8-A nrPDB 104 5e-23 4KS7-A nrPDB 104 5e-23 3SOA-A nrPDB 104 7e-23 6FD3-A nrPDB 103 1e-22 4WNO-A nrPDB 103 2e-22 6QAU-A nrPDB 102 2e-22 3RAW-A nrPDB 102 2e-22 4CQG-A nrPDB 102 3e-22 4LFI-A nrPDB 101 4e-22 4JXF-A nrPDB 101 6e-22 5IG1-A nrPDB 100 8e-22 3Q5I-A nrPDB 100 1e-21 4CZT-A nrPDB 100 1e-21 3Q53-A nrPDB 100 2e-21 4D28-A nrPDB 98 5e-21 1S9I-A nrPDB 98 5e-21 4C0T-A nrPDB 97 7e-21 2WO6-A nrPDB 97 8e-21 4D2V-A nrPDB 97 1e-20 6FDY-U nrPDB 97 1e-20 3COM-A nrPDB 97 1e-20 5J5T-A nrPDB 97 1e-20 3IS5-A nrPDB 96 2e-20 2W4O-A nrPDB 96 2e-20 5KKR-C nrPDB 96 3e-20 3EQC-A nrPDB 95 4e-20 3ORZ-A nrPDB 95 4e-20 4AN9-A nrPDB 95 4e-20 4YZB-A nrPDB 95 4e-20 2BRG-A nrPDB 94 1e-19 5WAX-A nrPDB 94 1e-19 3TAC-A nrPDB 93 2e-19 3F3Z-A nrPDB 93 2e-19 4B6L-A nrPDB 93 2e-19 3DB8-A nrPDB 93 2e-19 3VN9-A nrPDB 92 2e-19 4NIF-A nrPDB 92 4e-19 4CFH-A nrPDB 92 4e-19 3FME-A nrPDB 92 5e-19 4RED-A nrPDB 91 6e-19 1ZXE-A nrPDB 91 6e-19 4U41-A nrPDB 91 7e-19 2WQN-A nrPDB 91 7e-19 6AO5-A nrPDB 91 1e-18 4J52-A nrPDB 91 1e-18 5JZN-A nrPDB 91 1e-18 4LG4-A nrPDB 90 1e-18 4OW8-A nrPDB 90 1e-18 3D2K-A nrPDB 90 1e-18 2OU7-A nrPDB 90 1e-18 4YNZ-A nrPDB 90 1e-18 4REW-A nrPDB 90 1e-18 4UZD-A nrPDB 90 2e-18 4X3F-A nrPDB 90 2e-18 6CQF-A nrPDB 90 2e-18 6CMJ-A nrPDB 90 2e-18 5YKS-A nrPDB 90 2e-18 5XZW-A nrPDB 90 2e-18 6B2Q-A nrPDB 89 2e-18 2XNP-A nrPDB 89 2e-18 4CFF-A nrPDB 89 3e-18 5HVK-A nrPDB 89 4e-18 5EZV-A nrPDB 89 4e-18 2YZA-A nrPDB 88 6e-18 4JG6-A nrPDB 88 6e-18 5D7A-A nrPDB 88 7e-18 5ES1-A nrPDB 88 7e-18 4PDS-A nrPDB 87 2e-17 5KZ7-A nrPDB 86 2e-17 2UV2-A nrPDB 86 3e-17 2QNJ-A nrPDB 86 3e-17 3KN6-A nrPDB 86 3e-17 3UTO-A nrPDB 86 3e-17 1KOA-A nrPDB 86 4e-17 4M7I-A nrPDB 85 4e-17 6E2O-A nrPDB 84 6e-17 2WTK-C nrPDB 84 7e-17 3UC3-A nrPDB 84 8e-17 5YV8-A nrPDB 84 8e-17 4APC-A nrPDB 84 1e-16 2W1I-A nrPDB 84 1e-16 3IO7-A nrPDB 83 2e-16 3QA8-A nrPDB 83 2e-16 6C9D-A nrPDB 83 2e-16 3HKO-A nrPDB 83 2e-16 3LM0-A nrPDB 82 2e-16 1VZO-A nrPDB 82 2e-16 3ZUT-A nrPDB 82 2e-16 3DAK-A nrPDB 82 2e-16 2Z7Q-A nrPDB 82 3e-16 5FET-A nrPDB 82 3e-16 3ALO-A nrPDB 82 4e-16 3MV5-A nrPDB 82 5e-16 6CTH-A nrPDB 81 6e-16 2J90-A nrPDB 81 6e-16 5KCV-A nrPDB 81 7e-16 1KOB-A nrPDB 81 7e-16 3HDN-A nrPDB 81 7e-16 4I6B-A nrPDB 81 8e-16 2HAK-A nrPDB 81 8e-16 2JDO-A nrPDB 80 9e-16 5DBX-A nrPDB 80 1e-15 5D9K-A nrPDB 80 1e-15 1JPA-A nrPDB 80 1e-15 2VWV-A nrPDB 80 1e-15 4L42-A nrPDB 80 1e-15 3UDB-A nrPDB 80 1e-15 1TKI-A nrPDB 80 2e-15 5H2U-A nrPDB 80 2e-15 5F9E-A nrPDB 80 2e-15 3GUB-A nrPDB 80 2e-15 4RLP-A nrPDB 79 2e-15 5DYK-A nrPDB 79 2e-15 2RIO-A nrPDB 79 3e-15 3PPZ-A nrPDB 79 3e-15 4B8L-A nrPDB 79 3e-15 3QD2-B nrPDB 79 3e-15 4GS6-A nrPDB 79 4e-15 4WB7-A nrPDB 78 5e-15 4E93-A nrPDB 78 5e-15 2H8H-A nrPDB 78 6e-15 6BXI-A nrPDB 78 6e-15 4KIK-B nrPDB 78 7e-15 6F3F-A nrPDB 77 8e-15 6ED6-A nrPDB 77 8e-15 2XIK-A nrPDB 77 8e-15 4EQM-A nrPDB 77 9e-15 5N23-A nrPDB 77 1e-14 6HXF-B nrPDB 77 1e-14 5MJB-A nrPDB 77 1e-14 5L6P-A nrPDB 77 1e-14 4RC3-A nrPDB 76 2e-14 5TUR-A nrPDB 76 2e-14 3BGP-A nrPDB 76 2e-14 2DQ7-X nrPDB 76 2e-14 3ORP-A nrPDB 76 2e-14 5X3F-B nrPDB 76 3e-14 2HW6-A nrPDB 75 3e-14 6HV0-A nrPDB 75 3e-14 4PL5-B nrPDB 75 4e-14 4C59-A nrPDB 75 4e-14 3OMV-A nrPDB 75 4e-14 5SYS-A nrPDB 75 4e-14 4CSV-A nrPDB 75 5e-14 4TNB-A nrPDB 75 5e-14 6CCF-A nrPDB 75 5e-14 4XEY-B nrPDB 75 6e-14 1U5R-A nrPDB 75 6e-14 3FXW-A nrPDB 75 6e-14 6NPU-A nrPDB 75 6e-14 1K9A-A nrPDB 74 8e-14 6E9W-A nrPDB 74 9e-14 1BYG-A nrPDB 74 9e-14 2GCD-A nrPDB 74 9e-14 2A27-A nrPDB 74 9e-14 1ZWS-A nrPDB 74 1e-13 6CKI-A nrPDB 74 1e-13 2YAB-A nrPDB 73 2e-13 6GQK-A nrPDB 73 2e-13 2FO0-A nrPDB 73 2e-13 4FR4-A nrPDB 73 2e-13 1FOT-A nrPDB 73 2e-13 4PDO-A nrPDB 73 2e-13 5GRN-A nrPDB 72 3e-13 2R2P-A nrPDB 72 3e-13 5B2L-A nrPDB 72 3e-13 4AF3-A nrPDB 72 3e-13 3DTC-A nrPDB 72 3e-13 4UY9-A nrPDB 72 4e-13 6DBN-A nrPDB 72 4e-13 4QMW-A nrPDB 72 4e-13 2PMN-X nrPDB 72 5e-13 3NYO-A nrPDB 72 5e-13 3LLT-A nrPDB 72 5e-13 2Y6O-A nrPDB 71 5e-13 5EG3-A nrPDB 71 5e-13 4FZF-B nrPDB 71 6e-13 3DKO-A nrPDB 71 7e-13 4NEU-A nrPDB 70 1e-12 2PSQ-A nrPDB 70 1e-12 4OTD-A nrPDB 70 1e-12 5UUU-A nrPDB 70 1e-12 4E20-A nrPDB 70 2e-12 3PVW-A nrPDB 70 2e-12 3DLS-A nrPDB 70 2e-12 6J5U-C nrPDB 70 2e-12 6DBM-A nrPDB 70 2e-12 3KA0-A nrPDB 69 2e-12 4P5Q-A nrPDB 69 2e-12 4TPT-A nrPDB 69 3e-12 6BDL-A nrPDB 69 3e-12 5O0Y-A nrPDB 69 3e-12 2HK5-A nrPDB 69 4e-12 4HVI-A nrPDB 69 4e-12 2XYN-A nrPDB 68 5e-12 4CRS-A nrPDB 68 6e-12 4LQP-A nrPDB 68 7e-12 3BEA-A nrPDB 68 7e-12 5VD3-A nrPDB 68 8e-12 4OLI-A nrPDB 67 9e-12 4RA4-A nrPDB 67 1e-11 2OZA-A nrPDB 67 1e-11 4F9B-A nrPDB 67 1e-11 1NY3-A nrPDB 67 1e-11 3KUL-B nrPDB 67 2e-11 5X5O-A nrPDB 66 2e-11 4UYA-A nrPDB 66 2e-11 5LPV-A nrPDB 66 2e-11 5LPZ-A nrPDB 66 2e-11 4XI2-A nrPDB 66 2e-11 2PL0-A nrPDB 66 3e-11 4Y93-A nrPDB 65 4e-11 6E4F-A nrPDB 65 4e-11 5XD6-A nrPDB 65 5e-11 5TQX-A nrPDB 65 5e-11 2X4F-A nrPDB 65 5e-11 3A4O-X nrPDB 65 6e-11 5LOH-A nrPDB 64 8e-11 3TKU-A nrPDB 64 8e-11 2A1A-B nrPDB 64 1e-10 4IDT-A nrPDB 64 1e-10 5UIU-A nrPDB 64 1e-10 5HIE-A nrPDB 63 2e-10 3TXO-A nrPDB 63 2e-10 3CJF-A nrPDB 63 2e-10 2I0E-A nrPDB 62 3e-10 4AW2-A nrPDB 62 3e-10 6FER-A nrPDB 62 4e-10 5HI2-A nrPDB 62 4e-10 3V5Q-A nrPDB 62 4e-10 3TT0-A nrPDB 62 5e-10 4JLC-A nrPDB 61 6e-10 3PFQ-A nrPDB 61 6e-10 5IKW-A nrPDB 61 7e-10 4EUT-A nrPDB 61 7e-10 4G3E-A nrPDB 61 7e-10 4X7Q-B nrPDB 61 7e-10 6O8B-A nrPDB 61 8e-10 3GQL-A nrPDB 61 8e-10 6FEX-A nrPDB 61 8e-10 5E8V-A nrPDB 61 8e-10 4EUU-A nrPDB 61 9e-10 5X02-A nrPDB 61 9e-10 1U54-B nrPDB 61 9e-10 4YHJ-A nrPDB 61 9e-10 4K33-A nrPDB 60 1e-09 3UIU-A nrPDB 60 1e-09 5TOS-A nrPDB 60 1e-09 4XUF-A nrPDB 60 1e-09 1AD5-A nrPDB 60 1e-09 6NT9-A nrPDB 60 1e-09 2OGV-A nrPDB 60 1e-09 4HZS-A nrPDB 60 1e-09 3KRL-A nrPDB 60 2e-09 6GVJ-A nrPDB 60 2e-09 3HMP-A nrPDB 60 2e-09 3C51-A nrPDB 60 2e-09 5C26-A nrPDB 60 2e-09 4FL3-A nrPDB 60 2e-09 3BBT-B nrPDB 60 2e-09 3HNG-A nrPDB 59 2e-09 4EBW-A nrPDB 59 2e-09 5A46-A nrPDB 59 3e-09 4XCU-A nrPDB 59 3e-09 2ZMD-A nrPDB 59 3e-09 6BFN-A nrPDB 59 3e-09 5AP3-A nrPDB 59 4e-09 3A8W-A nrPDB 59 4e-09 2H34-A nrPDB 59 4e-09 6BSD-A nrPDB 59 5e-09 2J0K-A nrPDB 59 5e-09 2JD5-A nrPDB 58 5e-09 4Y83-A nrPDB 58 5e-09 5WNO-A nrPDB 58 5e-09 5VO2-A nrPDB 58 6e-09 4AT3-A nrPDB 58 7e-09 3G0E-A nrPDB 58 7e-09 2BUJ-A nrPDB 57 8e-09 4R7H-A nrPDB 57 1e-08 2VD5-A nrPDB 57 1e-08 1U59-A nrPDB 57 2e-08 3PP0-A nrPDB 56 2e-08 3VHK-A nrPDB 56 3e-08 5KMM-A nrPDB 55 4e-08 3PLS-A nrPDB 55 4e-08 5TE0-A nrPDB 55 4e-08 3SOC-A nrPDB 55 4e-08 5AMN-A nrPDB 55 4e-08 2OZO-A nrPDB 55 4e-08 3C1X-A nrPDB 55 5e-08 4RT7-A nrPDB 55 6e-08 3LZB-A nrPDB 55 7e-08 5GNK-A nrPDB 55 7e-08 5HLW-A nrPDB 54 8e-08 5U6B-A nrPDB 54 1e-07 3ZZW-A nrPDB 54 2e-07 1FVR-A nrPDB 53 2e-07 3UIM-A nrPDB 53 2e-07 3Q4U-A nrPDB 53 2e-07 4H1J-A nrPDB 53 3e-07 5L2Q-C nrPDB 53 3e-07 3QGY-A nrPDB 52 3e-07 3M42-A nrPDB 52 3e-07 3SXS-A nrPDB 52 4e-07 2QLU-A nrPDB 52 5e-07 1LUF-A nrPDB 51 9e-07 5FM2-A nrPDB 51 9e-07 3MDY-A nrPDB 50 1e-06 4M69-B nrPDB 50 1e-06 4NFN-A nrPDB 50 1e-06 5CEK-A nrPDB 50 1e-06 4LRM-A nrPDB 50 2e-06 4BTK-A nrPDB 50 2e-06 6DC0-A nrPDB 50 2e-06 5WNL-A nrPDB 49 3e-06 4M66-A nrPDB 49 3e-06 4BTF-A nrPDB 49 3e-06 3ZBF-A nrPDB 49 4e-06 4YFF-A nrPDB 49 4e-06 4Y12-A nrPDB 49 5e-06 5O2B-A nrPDB 48 5e-06 5U6C-A nrPDB 48 6e-06 5O2C-A nrPDB 48 6e-06 3QUP-A nrPDB 48 8e-06 3MY0-A nrPDB 48 8e-06 2X7G-A nrPDB 48 8e-06 3I81-A nrPDB 47 1e-05 2PZI-A nrPDB 47 1e-05 5AR8-A nrPDB 47 1e-05 4XLV-A nrPDB 47 2e-05 3LMG-A nrPDB 46 2e-05 1PY5-A nrPDB 46 3e-05 5CLR-A nrPDB 45 4e-05 2QKW-B nrPDB 45 4e-05 3AOX-A nrPDB 45 5e-05 4PWN-A nrPDB 45 5e-05 4WUA-A nrPDB 44 8e-05 4JRN-A nrPDB 44 9e-05 2WTK-B nrPDB 43 2e-04 5J0A-A nrPDB 43 2e-04 3SV0-A nrPDB 43 2e-04 5X1R-A nrPDB 42 5e-04 5FQD-C nrPDB 42 5e-04 4TN6-A nrPDB 42 5e-04 2Y4I-B nrPDB 41 6e-04 4L68-A nrPDB 40 0.001 5X18-A nrPDB 40 0.002 3G2F-A nrPDB 40 0.002 1CSN-A nrPDB 39 0.004 5VC6-A nrPDB 38 0.007 4MWI-A nrPDB 38 0.007 4XHL-A nrPDB 37 0.009 2CMW-A nrPDB 37 0.010 3ENH-A nrPDB 37 0.013 4XHH-A nrPDB 37 0.019 6G4J-A nrPDB 36 0.028 4OAU-C nrPDB 36 0.032 4O1O-A nrPDB 35 0.052 4IX6-A nrPDB 35 0.064 4NT4-A nrPDB 34 0.097 5UU1-A nrPDB 33 0.19 5DMZ-A nrPDB 33 0.22 5M07-A nrPDB 33 0.28 2CHL-A nrPDB 32 0.40 4F0G-A nrPDB 32 0.44 5VDK-A nrPDB 32 0.50 5M3O-A nrPDB 31 0.62 4CI6-B nrPDB 31 0.82 2C47-A nrPDB 31 0.85 5OAT-A nrPDB 31 0.87 4AZW-A nrPDB 30 1.3 6EQI-C nrPDB 30 1.3 2RSV-A nrPDB 30 1.3 2LAV-A nrPDB 30 1.4 4AZV-A nrPDB 30 1.4 4EV1-A nrPDB 30 1.6 >2F9G-A nrPDB Length = 353 Score = 736 bits (1900), Expect = 0.0, Method: Compositional matrix adjust. Identities = 353/353 (100%), Positives = 353/353 (100%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI Sbjct: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ Sbjct: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT Sbjct: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG Sbjct: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA Sbjct: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 Query: 301 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS Sbjct: 301 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 >5NGU-A nrPDB Length = 381 Score = 354 bits (909), Expect = 3e-98, Method: Compositional matrix adjust. Identities = 178/351 (50%), Positives = 240/351 (68%), Gaps = 14/351 (3%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 M + V+++ + S +GEGAYG+VCSA VAIKKI PF+ + RTLREI Sbjct: 32 MVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREI 91 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 KIL F+HENII I +I R + E +VYI+Q+LM+TDL++++ TQ LS+DHI YF+YQ Sbjct: 92 KILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQ 151 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG-M 179 LR +K +H +NV+HRDLKPSNLL+N+ CDLK+CDFGLAR+ D P +G + Sbjct: 152 ILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD--------PDHDHTGFL 203 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 TEYVATRWYRAPE+ML S Y++++D+WS GCILAE+ RPIFPG+ Y QL I GI+ Sbjct: 204 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 263 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 G+P S DL CI + +AR Y+ SLP P ++FP + K +DLL +ML F+P KRI Sbjct: 264 GSP-SQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIE 322 Query: 300 AKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNE 350 ++AL HPYL+ Y+DP+DEP E + F+FD + L + LK+LI+ E Sbjct: 323 VEQALAHPYLEQYYDPSDEPIAE----APFKFDMELDDLPKEKLKELIFEE 369 >4QTB-A nrPDB Length = 380 Score = 348 bits (894), Expect = 1e-96, Method: Compositional matrix adjust. Identities = 177/351 (50%), Positives = 235/351 (66%), Gaps = 14/351 (3%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 M K +++ + +GEGAYG+V SA VAIKKI PF+ + RTLREI Sbjct: 31 MVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREI 90 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 +IL F+HEN+I I +I R + E +VYI+Q+LM+TDL++++ +Q LS+DHI YF+YQ Sbjct: 91 QILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQ 150 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG-M 179 LR +K +H +NV+HRDLKPSNLLIN+ CDLK+CDFGLARI D P +G + Sbjct: 151 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIAD--------PEHDHTGFL 202 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 TEYVATRWYRAPE+ML S Y++++D+WS GCILAE+ RPIFPG+ Y QL I GI+ Sbjct: 203 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 262 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 G+P S DL CI + +AR Y++SLP K+FP+ + K +DLL RML F+P KRIT Sbjct: 263 GSP-SQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRIT 321 Query: 300 AKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNE 350 +EAL HPYL+ Y+DP DEP E F F + L + LK+LI+ E Sbjct: 322 VEEALAHPYLEQYYDPTDEPVAE----EPFTFAMELDDLPKERLKELIFQE 368 >6DTL-A nrPDB Length = 364 Score = 341 bits (874), Expect = 4e-94, Method: Compositional matrix adjust. Identities = 177/337 (52%), Positives = 229/337 (67%), Gaps = 19/337 (5%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +G+GAYG+VCSA + T E VAIKKI FD + A RTLREIK+L+H HENI+ I +I Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 97 Query: 78 QRPDSFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 P FN+VYI ELM TDLH++I S Q LS++H QYF+YQ LR +K +H +NV+HR Sbjct: 98 IPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHR 157 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 DLKPSNLL+N+NCDLK+CDFGLAR+ ES MTEYV TRWYRAPE++L Sbjct: 158 DLKPSNLLLNANCDLKICDFGLARVTSES-----------DFMTEYVVTRWYRAPELLLN 206 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 S+ Y+ A+DVWS GCI EL R+P+FPGRD+ HQL L+ +IGTP + E+ A Sbjct: 207 SSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNEN--A 264 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 + YI+ LP YP + FP V+P IDL+++ML FDP +RIT +AL HPYL + HD + Sbjct: 265 KRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 324 Query: 317 DEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 DEPE IP F FD AL+ + +K+LI+ E + Sbjct: 325 DEPECT-IP---FNFDFENHALSEEQMKELIYREALA 357 >4ZSG-A nrPDB Length = 347 Score = 333 bits (855), Expect = 5e-92, Method: Compositional matrix adjust. Identities = 171/350 (48%), Positives = 240/350 (68%), Gaps = 14/350 (4%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKIL 63 + +++ ++++ +G GAYGVV SA + TG+ VAIKKI FD A RTLRE+KIL Sbjct: 1 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 60 Query: 64 KHFKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQT 121 KHFKH+NII I +I RP + F VY++ +LM++DLH++I S+Q L+ +H++YF+YQ Sbjct: 61 KHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQL 120 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 LR +K +H + VIHRDLKPSNLL+N NC+LK+ DFG+AR + S P Q MTE Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTS------PAEHQYFMTE 174 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 YVATRWYRAPE+ML+ +Y++A+D+WS GCI E+ RR +FPG++Y HQL LI ++GT Sbjct: 175 YVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGT 234 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 P S ++ + + R R YI+SLP P E ++P + + + LL RML F+P+ RI+A Sbjct: 235 P-SPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAA 293 Query: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 AL HP+L YHDP+DEP+ PP F FD +EALT + +K+ I EI Sbjct: 294 AALRHPFLAKYHDPDDEPDCA--PPFDFAFD--REALTRERIKEAIVAEI 339 >4IC8-A nrPDB Length = 442 Score = 333 bits (853), Expect = 8e-92, Method: Compositional matrix adjust. Identities = 171/350 (48%), Positives = 242/350 (69%), Gaps = 14/350 (4%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKIL 63 + +++ ++++ +G GAYGVV SA + TG+ VAIKKI FD A RTLRE+KIL Sbjct: 49 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 108 Query: 64 KHFKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQT 121 KHFKH+NII I +I RP + F VY++ +LM++DLH++I S+Q L+ +H++YF+YQ Sbjct: 109 KHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQL 168 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 LR +K +H + VIHRDLKPSNLL+N NC+LK+ DFG+AR + S A++ Q MTE Sbjct: 169 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEH------QYFMTE 222 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 YVATRWYRAPE+ML+ +Y++A+D+WS GCI E+ RR +FPG++Y HQL LI ++GT Sbjct: 223 YVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGT 282 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 P S ++ + + R R YI+SLP P E ++P + + + LL RML F+P+ RI+A Sbjct: 283 P-SPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAA 341 Query: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 AL HP+L YHDP+DEP+ PP F FD +EALT + +K+ I EI Sbjct: 342 AALRHPFLAKYHDPDDEPDC--APPFDFAFD--REALTRERIKEAIVAEI 387 >5Z33-A nrPDB Length = 425 Score = 330 bits (845), Expect = 7e-91, Method: Compositional matrix adjust. Identities = 172/349 (49%), Positives = 233/349 (66%), Gaps = 20/349 (5%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFK 67 + + + LG+GAYG+VC+A + T E VAIKK+ F K + A R LREIK+L+HF+ Sbjct: 29 VDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFR 88 Query: 68 -HENIITIFN--IQRPDSFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQTLR 123 H NI +++ I RPD NFNE Y+ +ELM+ DL +I S Q L+D H Q FIYQ L Sbjct: 89 GHRNITCLYDMDIPRPD---NFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILC 145 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 +K +H +NV+HRDLKP NLL+N++C+LK+CDFGLAR + D E G MTEYV Sbjct: 146 GLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGF---SVDPEENAGY---MTEYV 199 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 ATRWYRAPE+ML+ Y++A+DVWS GCILAEL RP F GRDY QL I I+GTP+ Sbjct: 200 ATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPN 259 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 + L I SPRA+EY+++LP P +FP NP +DLL RML FDP+ RI+ ++A Sbjct: 260 EET-LSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQA 318 Query: 304 LEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIF 352 LEHPYL +HD +DEP+ P+ F FD ++ +++K+I +E++ Sbjct: 319 LEHPYLHIWHDASDEPDC----PTTFNFD-FEVVEDVGEMRKMILDEVY 362 >4EWQ-A nrPDB Length = 383 Score = 313 bits (803), Expect = 5e-86, Method: Compositional matrix adjust. Identities = 158/353 (44%), Positives = 219/353 (62%), Gaps = 21/353 (5%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIK 61 + ++ + +Q S +G GAYG VC+A TG VA+KK+ PF + A RT RE++ Sbjct: 37 NKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELR 96 Query: 62 ILKHFKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 +LKH KHEN+I + ++ P S E FN+VY++ LM DL+ ++ Q L+DDH+Q+ IYQ Sbjct: 97 LLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQ 156 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 LR +K +H +++IHRDLKPSNL +N +C+LK+ DFGLAR D+ MT Sbjct: 157 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------------MT 203 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 YVATRWYRAPE+ML Y++ +D+WS GCI+AEL R +FPG D+ QL LI ++G Sbjct: 204 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 263 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 TP ++ L+ I S AR YI+SL P +F NP +DLL++MLV D KRITA Sbjct: 264 TPGAEL-LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA 322 Query: 301 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 +AL H Y YHDP+DEP +P SF D L + K L ++E+ S Sbjct: 323 AQALAHAYFAQYHDPDDEPVADPYDQSFESRD-----LLIDEWKSLTYDEVIS 370 >3OHT-A nrPDB Length = 389 Score = 311 bits (798), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 158/352 (44%), Positives = 217/352 (61%), Gaps = 21/352 (5%) Query: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKI 62 + ++ + +Q S +G GAYG VCS+ +G +A+KK+ PF + A RT RE+++ Sbjct: 44 KTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRL 103 Query: 63 LKHFKHENIITIFNIQRP-DSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQT 121 LKH KHEN+I + ++ P S E FN+VY++ LM DL+ ++ Q L+DDH+Q+ IYQ Sbjct: 104 LKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQI 163 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 LR +K +H +++IHRDLKPSNL +N +C+LK+ DFGLAR D+ MT Sbjct: 164 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------------MTG 210 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 YVATRWYRAPE+ML Y+ +D+WS GCI+AEL R +FPG D+ +QL I + GT Sbjct: 211 YVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGT 270 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 P + R + S AR YI SLP P +F NP +DLL++MLV D KRITA Sbjct: 271 PPASVISR-MPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITAS 329 Query: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 EAL HPY YHDP+DEPE EP SF L ++ K+L + E+ S Sbjct: 330 EALAHPYFSQYHDPDDEPESEPYDQSF-----ESRQLEIEEWKRLTYEEVCS 376 >3GC9-A nrPDB Length = 370 Score = 306 bits (783), Expect = 1e-83, Method: Compositional matrix adjust. Identities = 158/354 (44%), Positives = 216/354 (61%), Gaps = 25/354 (7%) Query: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKI 62 + V+ + Q +G GAYG VCSA + VA+KK+ PF + A RT RE+++ Sbjct: 21 KTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL 80 Query: 63 LKHFKHENIITIFNIQRP-DSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQT 121 LKH KHEN+I + ++ P S E+F+EVY++ LM DL+ ++ +Q LSD+H+Q+ +YQ Sbjct: 81 LKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQALSDEHVQFLVYQL 140 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 LR +K +H + +IHRDLKPSN+ +N + +L++ DFGLAR DE MT Sbjct: 141 LRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEE-------------MTG 187 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 YVATRWYRAPE+ML Y++ +D+WS GCI+AEL + +FPG DY QL I ++GT Sbjct: 188 YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGT 247 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 P S L I S AR YI+SLP P L +F NP IDLL RMLV D +R++A Sbjct: 248 P-SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA 306 Query: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEA--LTTKDLKKLIWNEIFS 353 EAL H Y YHDP DEPE EP +D EA T ++ K+L + E+ S Sbjct: 307 EALAHAYFSQYHDPEDEPEAEP-------YDESVEAKERTLEEWKELTYQEVLS 353 >4QNY-A nrPDB Length = 354 Score = 288 bits (736), Expect = 4e-78, Method: Compositional matrix adjust. Identities = 148/349 (42%), Positives = 219/349 (62%), Gaps = 20/349 (5%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATH-KPTGEIVAIKKI--EPFDKPLFALRTLREIKI 62 V + + L+ ++G G+YGVV A K +VA+K++ E F++ + A R LREIK+ Sbjct: 15 VCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKL 74 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQT 121 L HF +NII + NI P+ ENF+ YI+ ++M+TDL +V+ S Q L++ HIQ+FIYQ Sbjct: 75 LAHFNDDNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQFFIYQA 134 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 LRA+ ++H + VIHRD+ P+N+L+N+NCDLK+CDFGLA+ E Q MT+ Sbjct: 135 LRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAK----------EENDQGEYMTD 184 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 YV RWYRAPE+++ YS +DVW GCIL EL RP+F G+D +QL I +IGT Sbjct: 185 YVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGT 244 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 P S+ D+ + S A++Y+K P A + +P +P+ +DLL+ MLVF+P +RIT Sbjct: 245 P-SEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVL 303 Query: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNE 350 +A+ HP+L+ HD D + + + F FD E T D+K+ I+ E Sbjct: 304 QAMRHPFLEQLHDDAD----DNLSYALFRFDE-NEQKTIVDVKRAIYEE 347 >4MYG-A nrPDB Length = 372 Score = 279 bits (713), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 140/335 (41%), Positives = 207/335 (61%), Gaps = 21/335 (6%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +G GAYG VCSA K +GE VAIKK+ PF +FA R RE+ +LKH +HEN+I + ++ Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 78 QRP-DSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 P S NF + Y++ MQTDL +++ + S++ IQY +YQ L+ +K +H + V+HR Sbjct: 111 FTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKIQYLVYQMLKGLKYIHSAGVVHR 169 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 DLKP NL +N +C+LK+ DFGLAR D + MT YV TRWYRAPEV+L+ Sbjct: 170 DLKPGNLAVNEDCELKILDFGLARHAD-------------AEMTGYVVTRWYRAPEVILS 216 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 Y++ +D+WS GCI+AE+ + +F G+DY QL I + G P ++ ++ + A Sbjct: 217 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF-VQKLNDKAA 275 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 + YI+SLP P ++FPR +P+ DLL++ML D KR+TA +AL HP+ + + DP Sbjct: 276 KSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPE 335 Query: 317 DEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 +E E + P +H E LT + K+ I+ EI Sbjct: 336 EETEAQ--QPFDDSLEH--EKLTVDEWKQHIYKEI 366 >1CM8-A nrPDB Length = 367 Score = 277 bits (708), Expect = 5e-75, Method: Compositional matrix adjust. Identities = 135/337 (40%), Positives = 204/337 (60%), Gaps = 21/337 (6%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +G GAYG VCSA TG VAIKK+ PF LFA R RE+++LKH +HEN+I + ++ Sbjct: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 Query: 78 QRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 PD + ++F + Y++ M TDL +++ + L +D IQ+ +YQ L+ ++ +H + +IHR Sbjct: 93 FTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHR 152 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 DLKP NL +N +C+LK+ DFGLAR D S MT YV TRWYRAPEV+L Sbjct: 153 DLKPGNLAVNEDCELKILDFGLARQAD-------------SEMTGYVVTRWYRAPEVILN 199 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 +Y++ +D+WS GCI+AE+ + +F G D+ QL I + GTP ++ R ++S A Sbjct: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR-LQSDEA 258 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 + Y+K LP + +P ++LL++MLV D +R+TA EAL HPY ++ HD Sbjct: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 Query: 317 DEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 DEP+ + SF + D T + K++ + E+ S Sbjct: 319 DEPQVQKYDDSFDDVDR-----TLDEWKRVTYKEVLS 350 >3OZ6-A nrPDB Length = 388 Score = 260 bits (665), Expect = 5e-70, Method: Compositional matrix adjust. Identities = 148/380 (38%), Positives = 225/380 (59%), Gaps = 42/380 (11%) Query: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKI 62 R+ ++ ++L LG+GAYG+V + + TGE+VA+KKI + F A RT REI I Sbjct: 2 RVDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMI 61 Query: 63 LKHFK-HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQT 121 L HENI+ + N+ R D N +VY++ + M+TDLH VI +L H QY +YQ Sbjct: 62 LTELSGHENIVNLLNVLRAD---NDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQL 118 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARI----------IDESAADNSE 171 ++ +K LH ++HRD+KPSN+L+N+ C +KV DFGL+R I S +N+E Sbjct: 119 IKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTE 178 Query: 172 P-TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 Q +T+YVATRWYRAPE++L S KY++ +D+WS GCIL E+ +PIFPG + Sbjct: 179 NFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMN 238 Query: 231 QLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPA----------APLEKMFPRVNP 280 QL I G+I P S+ D+ I+SP A+ I+SL + + ++NP Sbjct: 239 QLERIIGVIDFP-SNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINP 297 Query: 281 K------GIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPNDEPEGE---PIPPSFFEF 331 K +DLL ++L F+P KRI+A +AL+HP++ +H+PN+EP + IP + Sbjct: 298 KADCNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPIN---- 353 Query: 332 DHYKEALTTKDLKKLIWNEI 351 D+ K ++ D + L+++EI Sbjct: 354 DNVKHSI--DDYRNLVYSEI 371 >4O2Z-A nrPDB Length = 377 Score = 258 bits (659), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 144/359 (40%), Positives = 209/359 (58%), Gaps = 32/359 (8%) Query: 6 VYNIS-------SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTL 57 VYN+S S + L +LG GAYG+ CS TGE V+IKK + F R L Sbjct: 33 VYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVL 92 Query: 58 REIKILKHFKHENIITIFNIQRP--DSFENFNEVYIIQELMQTDLHRVI-STQMLSDDHI 114 REI +++ F HEN++ + NI P + +F +VY++ LM D++ V+ S Q+L + H+ Sbjct: 93 REIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEESHM 152 Query: 115 QYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTG 174 QYF+YQ LR +K LH +NV HRDLKP+NL+ N +C+LK+ DFGL+R +D ++ Sbjct: 153 QYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSE------ 206 Query: 175 QQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLL 234 +T+YV TRWYR PE++L + YS A+D+WS GCI AE++ R+P+FPGR+ QL + Sbjct: 207 ----LTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRM 262 Query: 235 IFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRV--NPKGIDLLQRMLVF 292 I IG P + +E A E + LP + + K+ P + N +GID L +M Sbjct: 263 IAQHIGKPPAS----IVEHREALEKLNELP-DGSLNIPKLVPGLAGNTEGIDFLSKMWTL 317 Query: 293 DPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 DP+KR TA + L HPYL HD DEP P F + H + +L++ W +I Sbjct: 318 DPSKRPTAADMLAHPYLAHLHDEEDEPTC----PCPFLWAHESTPMGVSELRRAFWADI 372 >3N9X-A nrPDB Length = 432 Score = 233 bits (593), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 132/344 (38%), Positives = 194/344 (56%), Gaps = 43/344 (12%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP-FDKPLFALRTLREIKILKHFK 67 + ++ +K L+G G+YG V A K T + VAIKK+ F+ + R LREI IL K Sbjct: 24 VPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLK 83 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-LSDDHIQYFIYQTLRAVK 126 + II ++++ PD F+E+YI+ E+ +DL ++ T + L+++HI+ +Y L Sbjct: 84 SDYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIFLTEEHIKTILYNLLLGEN 143 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESA--------ADNSEP----TG 174 +H S +IHRDLKP+N L+N +C +KVCDFGLAR I+ +N EP Sbjct: 144 FIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKN 203 Query: 175 QQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-----------LRRPIF 223 + +T +V TRWYRAPE++L Y++++D+WS GCI AEL R P+F Sbjct: 204 LKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLF 263 Query: 224 PG-----------------RDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMY 266 PG + R QL +IF IIGTP D DL+ I P +YIK P Sbjct: 264 PGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTED-DLKNINKPEVIKYIKLFPHR 322 Query: 267 PAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 L++ +P ++ GI+LL+ ML F+P KRIT +AL+HPYL+ Sbjct: 323 KPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLK 366 >3RP9-A nrPDB Length = 458 Score = 232 bits (591), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 129/354 (36%), Positives = 189/354 (53%), Gaps = 51/354 (14%) Query: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKH 65 + I ++++ L+G G+YG VC A K +VAIKKI F+ + R LREI IL Sbjct: 49 WQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNR 108 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-LSDDHIQYFIYQTLRA 124 H++++ + +I P E F+E+Y++ E+ +D ++ T + L++ HI+ +Y L Sbjct: 109 LNHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLLVG 168 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSE------------- 171 VK +H + ++HRDLKP+N L+N +C +KVCDFGLAR +D NS+ Sbjct: 169 VKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLV 228 Query: 172 ----PTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL--------- 218 + +T +V TRWYRAPE++L Y+ A+DVWS GCI AEL Sbjct: 229 TFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYH 288 Query: 219 --RRPIFPG--------------------RDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 R P+FPG R R QL +IF I+GTP S+ D+ +E A Sbjct: 289 ADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTP-SEEDIEALEKEDA 347 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 + YI+ P L + FP + I LL+RMLVF+P KRIT E L HP+ + Sbjct: 348 KRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFK 401 >1JNK-A nrPDB Length = 423 Score = 229 bits (584), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 132/354 (37%), Positives = 192/354 (54%), Gaps = 42/354 (11%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +G GA G+VC+A VAIKK+ PF A R RE+ ++K H+NII++ N+ Sbjct: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 Query: 78 QRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 P + E F +VY++ ELM +L +VI + L + + Y +YQ L +K LH + +IHR Sbjct: 130 FTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHR 188 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 DLKPSN+++ S+C LK+ DFGLAR G MT YV TR+YRAPEV+L Sbjct: 189 DLKPSNIVVKSDCTLKILDFGLART-----------AGTSFMMTPYVVTRYYRAPEVILG 237 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIE---- 252 Y +D+WS GCI+ E+ + +FPGRDY Q + +GTP C E Sbjct: 238 MG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP-------CPEFMKK 289 Query: 253 -SPRAREYIKSLPMYPAAPLEKMFPRV------------NPKGIDLLQRMLVFDPAKRIT 299 P R Y+++ P Y K+FP + DLL +MLV DPAKRI+ Sbjct: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 Query: 300 AKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 +AL+HPY+ ++DP E E PP ++ + T ++ K+LI+ E+ + Sbjct: 350 VDDALQHPYINVWYDP---AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 >3E7O-A nrPDB Length = 360 Score = 228 bits (580), Expect = 4e-60, Method: Compositional matrix adjust. Identities = 132/360 (36%), Positives = 195/360 (54%), Gaps = 32/360 (8%) Query: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKH 65 + + +Q +G GA G+VC+A G VA+KK+ PF A R RE+ +LK Sbjct: 18 FTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKC 77 Query: 66 FKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRA 124 H+NII++ N+ P + E F +VY++ ELM +L +VI + L + + Y +YQ L Sbjct: 78 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLYQMLCG 136 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 +K LH + +IHRDLKPSN+++ S+C LK+ DFGLAR +A+ N MT YV Sbjct: 137 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR----TASTNFM-------MTPYVV 185 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 TR+YRAPEV+L Y +D+WS GCI+ EL IF G D+ Q + +GTP + Sbjct: 186 TRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSA 244 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRV------------NPKGIDLLQRMLVF 292 + P R Y+++ P YP E++FP + DLL +MLV Sbjct: 245 --EFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVI 302 Query: 293 DPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIF 352 DP KRI+ EAL HPY+ ++DP E E PP ++ + ++ K+LI+ E+ Sbjct: 303 DPDKRISVDEALRHPYITVWYDP---AEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVM 359 >3PG1-A nrPDB Length = 362 Score = 226 bits (575), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 130/365 (35%), Positives = 204/365 (55%), Gaps = 43/365 (11%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI----------EPFDKPLFALR 55 ++ + S + ++ + G+YG VC+ G VAIK++ R Sbjct: 17 LHAMQSPYTVQRFISSGSYGAVCAGV-DSEGIPVAIKRVFNTVSDGRTVNILSDSFLCKR 75 Query: 56 TLREIKILKHFKHENIITIFNIQRPDSFENFNE-----VYIIQELMQTDLHRVISTQ--M 108 LREI++L HF H NI+ + +I F +F E +Y++ ELM+TDL +VI Q + Sbjct: 76 VLREIRLLNHFHHPNILGLRDI-----FVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIV 130 Query: 109 LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAAD 168 +S HIQYF+Y L + VLH + V+HRDL P N+L+ N D+ +CDF LAR E AD Sbjct: 131 ISPQHIQYFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAR---EDTAD 187 Query: 169 NSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDY 228 ++ T YV RWYRAPE+++ +++ +D+WS GC++AE+F R+ +F G + Sbjct: 188 ANK--------THYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTF 239 Query: 229 RHQLLLIFGIIGTPHSDNDLRCIESPRAREYIK-SLPMYPAAPLEKMFPRVNPKGIDLLQ 287 +QL I ++GTP + D+ SP AR+Y++ SL PA + P +P +DL+ Sbjct: 240 YNQLNKIVEVVGTPKIE-DVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIA 298 Query: 288 RMLVFDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALT-TKDLKKL 346 +ML F+P +RI+ ++AL HPY ++ DP D EG E H+ E++T D+ K+ Sbjct: 299 KMLEFNPQRRISTEQALRHPYFESLFDPLDLTEG------LSERFHFDESVTDVYDMHKI 352 Query: 347 IWNEI 351 E+ Sbjct: 353 FTAEV 357 >2XS0-A nrPDB Length = 386 Score = 220 bits (561), Expect = 7e-58, Method: Compositional matrix adjust. Identities = 131/353 (37%), Positives = 188/353 (53%), Gaps = 42/353 (11%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +G GA G+VC+A VAIKK+ PF A R RE+ ++K H+NII + N+ Sbjct: 34 IGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNV 93 Query: 78 QRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 P S E F +VYI+ ELM +L +VI + L + + Y +YQ L +K LH + +IHR Sbjct: 94 FTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHR 152 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 DLKPSN+++ S+C LK+ DFGLAR G M +V TR+YRAPEV+L Sbjct: 153 DLKPSNIVVKSDCTLKILDFGLART-----------AGTSFMMVPFVVTRYYRAPEVILG 201 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIE---- 252 Y +D+WS GCI+ E+ +FPG D+ Q + +GTP C E Sbjct: 202 MG-YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTP-------CPEFMKK 253 Query: 253 -SPRAREYIKSLPMYPAAPLEKMFPRV------------NPKGIDLLQRMLVFDPAKRIT 299 P R Y+++ P Y EK+FP V + DLL +MLV D +KRI+ Sbjct: 254 LQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS 313 Query: 300 AKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIF 352 EAL+HPY+ ++DP+ E E PP + + T ++ K+LI+ E+ Sbjct: 314 VDEALQHPYINVWYDPS---EAEAPPPKIPDKQLDEREHTIEEWKELIYKEVM 363 >3NIE-A nrPDB Length = 429 Score = 219 bits (558), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 126/355 (35%), Positives = 187/355 (52%), Gaps = 46/355 (12%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP-FDKPLFALRTLREIKILKHFK 67 + ++++K L+G G+YG V A K + VAIKK+ F+ + R LREI IL K Sbjct: 26 VPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLK 85 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-LSDDHIQYFIYQTLRAVK 126 + II + ++ P+ F+E+YI+ E+ +DL ++ T + L++ H++ +Y L K Sbjct: 86 SDYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIFLTEQHVKTILYNLLLGEK 145 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESA---------------ADNSE 171 +H S +IHRDLKP+N L+N +C +K+CDFGLAR I+ Sbjct: 146 FIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPH 205 Query: 172 PTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-----------LRR 220 + +T +V TRWYRAPE++L Y+ ++D+WS GCI AEL R Sbjct: 206 NKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRF 265 Query: 221 PIFPG-----------------RDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSL 263 P+FPG + R QL +IF +IGTP + DL+CI +YIK Sbjct: 266 PLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTP-PEEDLKCITKQEVIKYIKLF 324 Query: 264 PMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPNDE 318 P L K + ++ +GIDLL+ ML F+ KRIT +AL HPYL+ N E Sbjct: 325 PTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKENLE 379 >5AWM-A nrPDB Length = 394 Score = 218 bits (554), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 131/351 (37%), Positives = 186/351 (52%), Gaps = 37/351 (10%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +G GA G+VC+A T + VAIKK+ PF A R RE K++K H+NII + N Sbjct: 52 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNA 111 Query: 78 QRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 P + E F +VY++ ELM +L +VI L D + Y +YQ L +K LH + +IHR Sbjct: 112 FTPQRNLEEFQDVYLVMELMDANLCQVIQMD-LDHDRMSYLLYQMLCGIKHLHSAGIIHR 170 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 DLKPSN+++ ++C LK+ DFGLAR G MT YV TR+YRAPEV+L Sbjct: 171 DLKPSNIVVKADCTLKILDFGLART-----------AGTTFMMTPYVVTRYYRAPEVIL- 218 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 Y+ +D+WS GCI+ E+ +FPG D+ Q I +GTP R P Sbjct: 219 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRL--QPTV 276 Query: 257 REYIKSLPMYPAAPLEKMFP-------------RVNPKGIDLLQRMLVFDPAKRITAKEA 303 R Y+++ P Y +++FP R +LL +MLV DP +RI+ EA Sbjct: 277 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 336 Query: 304 LEHPYLQTYHDPN--DEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIF 352 L+H Y+ ++D D P EP S E +H T + K+LI+ E+ Sbjct: 337 LKHEYINVWYDAEEVDAPAPEPYDHSVDEREH-----TVEQWKELIYEEVM 382 >3FI2-A nrPDB Length = 353 Score = 216 bits (549), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 121/314 (38%), Positives = 172/314 (54%), Gaps = 39/314 (12%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +G GA G+VC+A VAIKK+ PF A R RE+ ++K H+NII++ N+ Sbjct: 32 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 91 Query: 78 QRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 P + E F +VY++ ELM +L +VI + L + + Y +YQ L +K LH + +IHR Sbjct: 92 FTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHR 150 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 DLKPSN+++ S+C LK+ DFGLAR G MT YV TR+YRAPEV+L Sbjct: 151 DLKPSNIVVKSDCTLKILDFGLART-----------AGTSFMMTPYVVTRYYRAPEVILG 199 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIE---- 252 Y +D+WS GCI+ E+ + +FPGRDY Q + +GTP C E Sbjct: 200 MG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP-------CPEFMKK 251 Query: 253 -SPRAREYIKSLPMYPAAPLEKMFPRV------------NPKGIDLLQRMLVFDPAKRIT 299 P R Y+++ P Y K+FP + DLL +MLV DPAKRI+ Sbjct: 252 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 311 Query: 300 AKEALEHPYLQTYH 313 +AL+HPY+ ++ Sbjct: 312 VDDALQHPYINVWY 325 >2I6L-A nrPDB Length = 320 Score = 216 bits (549), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 120/330 (36%), Positives = 184/330 (55%), Gaps = 34/330 (10%) Query: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 +++ S + LG G G+V SA + VAIKKI D P LREIKI++ Sbjct: 7 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTD-PQSVKHALREIKIIRRL 65 Query: 67 KHENIITIFNIQRPD---------SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYF 117 H+NI+ +F I P S N VYI+QE M+TDL V+ L ++H + F Sbjct: 66 DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLF 125 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLINS-NCDLKVCDFGLARIIDESAADNSEPTGQQ 176 +YQ LR +K +H +NV+HRDLKP+NL IN+ + LK+ DFGLARI+D + + Sbjct: 126 MYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYS-------HK 178 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 ++E + T+WYR+P ++L+ Y++A+D+W+ GCI AE+ + +F G Q+ LI Sbjct: 179 GHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLIL 238 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPMY-------PAAPLEKMFPRVNPKGIDLLQRM 289 I H ++ +E + +P+Y P PL ++ P ++ + +D L+++ Sbjct: 239 ESIPVVHEED---------RQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQI 289 Query: 290 LVFDPAKRITAKEALEHPYLQTYHDPNDEP 319 L F P R+TA+EAL HPY+ Y P DEP Sbjct: 290 LTFSPMDRLTAEEALSHPYMSIYSFPMDEP 319 >6GU6-A nrPDB Length = 302 Score = 194 bits (493), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 109/297 (36%), Positives = 161/297 (54%), Gaps = 23/297 (7%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +GEG YGVV HK TG++VA+KKI ++ +REI +LK +H NI+++ ++ Sbjct: 15 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 74 Query: 78 QRPDSFENFNEVYIIQELMQTDLHRVIST----QMLSDDHIQYFIYQTLRAVKVLHGSNV 133 DS +Y+I E + DL + + + Q + ++ ++YQ L+ + H V Sbjct: 75 LMQDS-----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 129 Query: 134 IHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV 193 +HRDLKP NLLI+ +K+ DFGLAR T V T WYR+PEV Sbjct: 130 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI----------RVYTHEVVTLWYRSPEV 179 Query: 194 MLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIES 253 +L SA+YS +D+WS G I AEL ++P+F G QL IF +GTP N+ E Sbjct: 180 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTP---NNEVWPEV 236 Query: 254 PRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 ++Y + P + L ++ G+DLL +ML++DPAKRI+ K AL HPY Sbjct: 237 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 293 >3NIZ-A nrPDB Length = 311 Score = 191 bits (486), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 112/301 (37%), Positives = 164/301 (54%), Gaps = 21/301 (6%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENI 71 +Q +GEG YGVV A G IVA+K+I + +REI +LK H NI Sbjct: 23 YQKLEKVGEGTYGVVYKAKDS-QGRIVALKRIRLDAEDEGIPSTAIREISLLKELHHPNI 81 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI--STQMLSDDHIQYFIYQTLRAVKVLH 129 +++ ++ + + ++ E M+ DL +V+ + L D I+ ++YQ LR V H Sbjct: 82 VSLIDVIHSERC-----LTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCH 136 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 ++HRDLKP NLLINS+ LK+ DFGLAR T V T WYR Sbjct: 137 QHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPV----------RSYTHEVVTLWYR 186 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLR 249 AP+V++ S KYS ++D+WS GCI AE+ +P+FPG QL IF I+GTP+ + Sbjct: 187 APDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQ 246 Query: 250 CIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 E P ++ ++ ++ P + P +GIDLL ML FDP KRI+A++A+ HPY Sbjct: 247 VQELPLWKQ--RTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYF 304 Query: 310 Q 310 + Sbjct: 305 K 305 >2BPM-A nrPDB Length = 309 Score = 191 bits (485), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 114/309 (36%), Positives = 161/309 (52%), Gaps = 24/309 (7%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFAL--RTLREIKILKHFKHE 69 +FQ +GEG YGVV A +K TGE+VA+KKI D + +REI +LK H Sbjct: 8 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR-LDTETEGVPSTAIREISLLKELNHP 66 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSD---DHIQYFIYQTLRAVK 126 NI+ + ++ + N++Y++ E + DL + + L+ I+ +++Q L+ + Sbjct: 67 NIVKLLDVIHTE-----NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 121 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H V+HRDLKP NLLIN+ +K+ DFGLAR T V T Sbjct: 122 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV----------RTYTHEVVTL 171 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 WYRAPE++L YS A+D+WS GCI AE+ RR +FPG QL IF +GTP Sbjct: 172 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVV 231 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 P +Y S P + K+ P ++ G LL +ML +DP KRI+AK AL H Sbjct: 232 WPGVTSMP---DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAH 288 Query: 307 PYLQTYHDP 315 P+ Q P Sbjct: 289 PFFQDVTKP 297 >1V0B-A nrPDB Length = 288 Score = 190 bits (483), Expect = 6e-49, Method: Compositional matrix adjust. Identities = 116/296 (39%), Positives = 158/296 (53%), Gaps = 24/296 (8%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKHENIITIFN 76 +GEG YGVV A + GE A+KKI E D+ + + T+REI ILK KH NI+ ++ Sbjct: 10 IGEGTYGVVYKAQNN-YGETFALKKIRLEKEDEGIPS-TTIREISILKELKHSNIVKLY- 66 Query: 77 IQRPDSFENFNEVYIIQELMQTDLHRVIST--QMLSDDHIQYFIYQTLRAVKVLHGSNVI 134 D + ++ E + DL +++ L + F+ Q L + H V+ Sbjct: 67 ----DVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVL 122 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 HRDLKP NLLIN +LK+ DFGLAR T V T WYRAP+V+ Sbjct: 123 HRDLKPQNLLINREGELKIADFGLARAFGIPVRK----------YTHEVVTLWYRAPDVL 172 Query: 195 LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESP 254 + S KYS +D+WS GCI AE+ P+FPG QL+ IF I+GTP+S N E P Sbjct: 173 MGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELP 232 Query: 255 RAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 + Y + +Y P E ++ GIDLL +ML DP +RITAK+ALEH Y + Sbjct: 233 K---YDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFK 285 >4AU8-A nrPDB Length = 296 Score = 188 bits (478), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 113/302 (37%), Positives = 164/302 (54%), Gaps = 24/302 (7%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +GEG YG V A ++ T EIVA+K++ D LREI +LK KH+NI+ + ++ Sbjct: 14 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 73 Query: 78 QRPDSFENFNEVYIIQELMQTDLHRVIST--QMLSDDHIQYFIYQTLRAVKVLHGSNVIH 135 D ++ ++ E DL + + L + ++ F++Q L+ + H NV+H Sbjct: 74 LHSDK-----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 128 Query: 136 RDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVML 195 RDLKP NLLIN N +LK+ DFGLAR + V T WYR P+V+ Sbjct: 129 RDLKPQNLLINRNGELKLADFGLARAFGIPV----------RCYSAEVVTLWYRPPDVLF 178 Query: 196 TSAKYSRAMDVWSCGCILAELF-LRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESP 254 + YS ++D+WS GCI AEL RP+FPG D QL IF ++GTP + + P Sbjct: 179 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 238 Query: 255 RAREYIKSLPMYPA-APLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYH 313 + Y PMYPA L + P++N G DLLQ +L +P +RI+A+EAL+HPY + Sbjct: 239 DYKPY----PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFC 294 Query: 314 DP 315 P Sbjct: 295 PP 296 >4BGQ-A nrPDB Length = 304 Score = 182 bits (462), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 105/309 (33%), Positives = 172/309 (55%), Gaps = 18/309 (5%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDK-PLFALRTLREIKILK 64 + N+ + F++ ++GEGAYGVV HK T EIVAIKK + ++ TLRE+K+L+ Sbjct: 7 IGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLR 66 Query: 65 HFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST--QMLSDDHIQYFIYQTL 122 K ENI+ + ++F ++Y++ E ++ ++ ++ + + ++ +IYQ + Sbjct: 67 TLKQENIVEL-----KEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI 121 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 +A+ H ++++HRD+KP NLLI+ N LK+CDFG AR + E G + E Sbjct: 122 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSE---------GNNANYDEE 172 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 VATRWYR+PE++L A Y +++D+WS GCIL EL +P+FPG QL I ++G Sbjct: 173 VATRWYRSPELLL-GAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPL 231 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 S+ +PR +P + + +N +DL++ +L DPA R ++ Sbjct: 232 PSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQ 291 Query: 303 ALEHPYLQT 311 L HP QT Sbjct: 292 CLNHPTFQT 300 >4KRC-A nrPDB Length = 317 Score = 181 bits (460), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 105/318 (33%), Positives = 170/318 (53%), Gaps = 30/318 (9%) Query: 9 ISSDFQLKSL--LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 +SS Q K L LG G Y V +K TG VA+K+++ + +REI ++K Sbjct: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL 60 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSD-------DHIQYFIY 119 KHENI+ ++++ + N++ ++ E M DL + + ++ + + + ++YF + Sbjct: 61 KHENIVRLYDVIHTE-----NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 Q L+ + H + ++HRDLKP NLLIN LK+ DFGLAR + Sbjct: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPV----------NTF 165 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 + V T WYRAP+V++ S YS ++D+WSCGCILAE+ +P+FPG + QL LIF I+ Sbjct: 166 SSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIM 225 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR----VNPKGIDLLQRMLVFDPA 295 GTP+ + P+ I+ P P + + P ++ +D L +L +P Sbjct: 226 GTPNESLWPSVTKLPKYNPNIQQRP--PRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPD 283 Query: 296 KRITAKEALEHPYLQTYH 313 R++AK+AL HP+ Y+ Sbjct: 284 MRLSAKQALHHPWFAEYY 301 >1G3N-A nrPDB Length = 326 Score = 181 bits (459), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 112/318 (35%), Positives = 170/318 (53%), Gaps = 25/318 (7%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATH-KPTGEIVAIKKIE-PFDKPLFALRTLR 58 M K + ++ + +GEGAYG V A K G VA+K++ + L T+R Sbjct: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 Query: 59 EIKILKH---FKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ---MLSDD 112 E+ +L+H F+H N++ +F++ + ++ ++ E + DL + + + Sbjct: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 Query: 113 HIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEP 172 I+ ++Q LR + LH V+HRDLKP N+L+ S+ +K+ DFGLARI Sbjct: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---------- 170 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 Q +T V T WYRAPEV+L S+ Y+ +D+WS GCI AE+F R+P+F G QL Sbjct: 171 -SFQMALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 I +IG P ++ R + PR + KS A P+EK ++ G DLL + L F Sbjct: 229 GKILDVIGLPGEEDWPRDVALPRQAFHSKS-----AQPIEKFVTDIDELGKDLLLKCLTF 283 Query: 293 DPAKRITAKEALEHPYLQ 310 +PAKRI+A AL HPY Q Sbjct: 284 NPAKRISAYSALSHPYFQ 301 >1UA2-A nrPDB Length = 346 Score = 179 bits (455), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 108/305 (35%), Positives = 160/305 (52%), Gaps = 25/305 (8%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIE----PFDKPLFALRTLREIKILKHFKHENIIT 73 LGEG + V A K T +IVAIKKI+ K LREIK+L+ H NII Sbjct: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 Query: 74 IFNIQRPDSFENFNEVYIIQELMQTDLHRVI--STQMLSDDHIQYFIYQTLRAVKVLHGS 131 + D+F + + + ++ + M+TDL +I ++ +L+ HI+ ++ TL+ ++ LH Sbjct: 77 LL-----DAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 Query: 132 NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 ++HRDLKP+NLL++ N LK+ DFGLA+ T V TRWYRAP Sbjct: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP----------NRAYTHQVVTRWYRAP 181 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCI 251 E++ + Y +D+W+ GCILAEL LR P PG QL IF +GTP + Sbjct: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 Query: 252 ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQT 311 P +Y+ + +P PL +F +DL+Q + +F+P RITA +AL+ Y Sbjct: 242 SLP---DYV-TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 Query: 312 YHDPN 316 P Sbjct: 298 RPGPT 302 >4NST-A nrPDB Length = 351 Score = 177 bits (450), Expect = 5e-45, Method: Compositional matrix adjust. Identities = 107/314 (34%), Positives = 171/314 (54%), Gaps = 35/314 (11%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENI 71 F + ++GEG YG V A K TGE+VA+KK+ +K F + +REIKIL+ H ++ Sbjct: 15 FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSV 74 Query: 72 ITIFNI--QRPDSFE---NFNEVYIIQELMQTDLHRVISTQML--SDDHIQYFIYQTLRA 124 + + I + D+ + + Y++ E M DL ++ + ++ S+DHI+ F+ Q + Sbjct: 75 VNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEG 134 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 ++ H N +HRD+K SN+L+N++ +K+ DFGLAR+ + ++ S P T V Sbjct: 135 LEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYN---SEESRP------YTNKVI 185 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 T WYR PE++L +Y+ A+DVWSCGCIL ELF ++PIF QL LI + G+P Sbjct: 186 TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSP-- 243 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR--------VNPKGIDLLQRMLVFDPAK 296 P + LP + +K + R + +DLL ML DP+K Sbjct: 244 --------CPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSK 295 Query: 297 RITAKEALEHPYLQ 310 R TA++ L+ +L+ Sbjct: 296 RCTAEQTLQSDFLK 309 >5EFQ-A nrPDB Length = 347 Score = 177 bits (449), Expect = 6e-45, Method: Compositional matrix adjust. Identities = 112/329 (34%), Positives = 174/329 (52%), Gaps = 40/329 (12%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENI 71 F + ++GEG YG V A K TGE+VA+KK+ +K F + +REIKIL+ H++I Sbjct: 13 FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSI 72 Query: 72 ITIFNI--QRPDSFE---NFNEVYIIQELMQTDLHRVISTQML--SDDHIQYFIYQTLRA 124 I + I + D+ + + Y++ E M DL ++ + ++ +++HI+ F+ Q + Sbjct: 73 INMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEG 132 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + H N +HRD+K SN+L+N+ +K+ DFGLAR+ +++ S P T V Sbjct: 133 LDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLY---SSEESRP------YTNKVI 183 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 T WYR PE++L +Y+ A+DVWSCGCIL ELF ++PIF QL LI I G+P Sbjct: 184 TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSP-- 241 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR--------VNPKGIDLLQRMLVFDPAK 296 P + LP + +K + R + +DL ML DP+K Sbjct: 242 --------CPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSK 293 Query: 297 RITAKEALEHPYLQTYHDPNDEPEGEPIP 325 R TA++AL+ +L+ EP P P Sbjct: 294 RCTAEQALQCEFLRDV-----EPSKMPPP 317 >5G6V-A nrPDB Length = 324 Score = 175 bits (443), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 101/295 (34%), Positives = 154/295 (52%), Gaps = 23/295 (7%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 LGEG Y V K T +VA+K+I + +RE+ +LK KH NI+T+ +I Sbjct: 10 LGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDII 69 Query: 79 RPDSFENFNEVYIIQELMQTDLHRVIS--TQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 + + ++ E + DL + + +++ +++ F++Q LR + H V+HR Sbjct: 70 HTE-----KSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHR 124 Query: 137 DLKPSNLLINSNCDLKVCDFGLARI--IDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 DLKP NLLIN +LK+ DFGLAR I DN V T WYR P+++ Sbjct: 125 DLKPQNLLINERGELKLADFGLARAKSIPTKTYDNE------------VVTLWYRPPDIL 172 Query: 195 LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESP 254 L S YS +D+W GCI E+ RP+FPG QL IF I+GTP + + + Sbjct: 173 LGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNE 232 Query: 255 RAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 + Y + P Y A L PR++ G DLL ++L F+ RI+A++A++HP+ Sbjct: 233 EFKTY--NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >4AGU-A nrPDB Length = 311 Score = 173 bits (439), Expect = 9e-44, Method: Compositional matrix adjust. Identities = 106/311 (34%), Positives = 163/311 (52%), Gaps = 37/311 (11%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKK-IEPFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +GEG+YGVV ++ TG+IVAIKK +E D P+ LREI++LK KH N++ + + Sbjct: 11 IGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEV 70 Query: 78 QRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDH-IQYFIYQTLRAVKVLHGSNVIH 135 F ++++ E T LH + Q +H ++ +QTL+AV H N IH Sbjct: 71 -----FRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIH 125 Query: 136 RDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVML 195 RD+KP N+LI + +K+CDFG AR++ TG + VATRWYR+PE+++ Sbjct: 126 RDVKPENILITKHSVIKLCDFGFARLL----------TGPSDYYDDEVATRWYRSPELLV 175 Query: 196 TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPR 255 +Y +DVW+ GC+ AEL P++PG+ QL LI +G DL PR Sbjct: 176 GDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLG------DL----IPR 225 Query: 256 AREYIKSLPMYPAA---------PLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 ++ + + PLE FP ++ + LL+ L DP +R+T ++ L H Sbjct: 226 HQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHH 285 Query: 307 PYLQTYHDPND 317 PY + + D Sbjct: 286 PYFENIREIED 296 >2W96-B nrPDB Length = 306 Score = 169 bits (429), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 107/318 (33%), Positives = 163/318 (51%), Gaps = 27/318 (8%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKH--- 65 +S ++ + +G GAYG V A +G VA+K + P + + T+RE+ +L+ Sbjct: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEA 62 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ---MLSDDHIQYFIYQTL 122 F+H N++ + ++ + +V ++ E + DL + L + I+ + Q L Sbjct: 63 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 R + LH + ++HRDLKP N+L+ S +K+ DFGLARI Q + Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS-----------YQMALDPV 171 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 V T WYRAPEV+L S Y+ +D+WS GCI AE+F R+P+F G QL IF +IG P Sbjct: 172 VVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 230 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 D+ R + PR + P P++ + P + G LL ML F+P KRI+A Sbjct: 231 PEDDWPRDVSLPRG-----AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR 285 Query: 303 ALEHPYLQTYHDPNDEPE 320 AL+H YL H PE Sbjct: 286 ALQHSYL---HKDEGNPE 300 >4BBM-A nrPDB Length = 331 Score = 169 bits (428), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 98/309 (31%), Positives = 157/309 (50%), Gaps = 43/309 (13%) Query: 17 SLLGEGAYGVVCSATHKPTGEIVAIKK-IEPFDKPLFALRTLREIKILKHFKHENIITIF 75 L+GEG+YG+V +K TG IVAIKK +E D + +REIK+LK +HEN++ + Sbjct: 31 GLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLL 90 Query: 76 NIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQY-----FIYQTLRAVKVLHG 130 + + Y++ E + H ++ L + + Y +++Q + + H Sbjct: 91 EVCKKKK-----RWYLVFEFVD---HTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHS 142 Query: 131 SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRA 190 N+IHRD+KP N+L++ + +K+CDFG AR + + VATRWYRA Sbjct: 143 HNIIHRDIKPENILVSQSGVVKLCDFGFARTL----------AAPGEVYDDEVATRWYRA 192 Query: 191 PEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRC 250 PE+++ KY +A+DVW+ GC++ E+F+ P+FPG QL I +G Sbjct: 193 PELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNL-------- 244 Query: 251 IESPRAREYIKSLPMYPAA---------PLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 PR +E P++ PLE+ +P+++ IDL ++ L DP KR Sbjct: 245 --IPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCA 302 Query: 302 EALEHPYLQ 310 E L H + Q Sbjct: 303 ELLHHDFFQ 311 >3MIA-A nrPDB Length = 351 Score = 163 bits (412), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 106/316 (33%), Positives = 172/316 (54%), Gaps = 18/316 (5%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHE 69 S ++ + +G+G +G V A H+ TG+ VA+KK+ +K F + LREIKIL+ KHE Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Query: 70 NIITIFNIQRPDSFENFNE----VYIIQELMQTDLHRVISTQML--SDDHIQYFIYQTLR 123 N++ + I R + +N +Y++ + + DL ++S ++ + I+ + L Sbjct: 77 NVVNLIEICRTKA-SPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 + +H + ++HRD+K +N+LI + LK+ DFGLAR S A NS+P + T V Sbjct: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF--SLAKNSQP----NRYTNRV 189 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG--T 241 T WYR PE++L Y +D+W GCI+AE++ R PI G +HQL LI + G T Sbjct: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 P ++ E E +K L K + R +P +DL+ ++LV DPA+RI + Sbjct: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRL-KAYVR-DPYALDLIDKLLVLDPAQRIDSD 307 Query: 302 EALEHPYLQTYHDPND 317 +AL H + + P+D Sbjct: 308 DALNHDFFWSDPMPSD 323 >5AIR-A nrPDB Length = 430 Score = 162 bits (411), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 105/323 (32%), Positives = 171/323 (52%), Gaps = 30/323 (9%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITI--- 74 ++G G++GVV A +GE+VAIKK+ DK RE++I++ H NI+ + Sbjct: 71 VIGNGSFGVVYQAKLCDSGELVAIKKVLQ-DKRF----KNRELQIMRKLDHCNIVRLRYF 125 Query: 75 ---FNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGS 131 ++ + + N Y+ + + + H + Q L +++ ++YQ R++ +H Sbjct: 126 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 185 Query: 132 NVIHRDLKPSNLLINSNCD-LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRA 190 + HRD+KP NLL++ + LK+CDFG A+ + + S Y+ +R+YRA Sbjct: 186 GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS-----------YICSRYYRA 234 Query: 191 PEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRC 250 PE++ + Y+ ++DVWS GC+LAEL L +PIFPG QL+ I ++GTP + +R Sbjct: 235 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ-IRE 293 Query: 251 IESPRAREYIKSLPMYPAAPLEKMF-PRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 + +P E+ P A P K+F PR P+ I L R+L + P R+T EA H + Sbjct: 294 M-NPNYTEF--KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 350 Query: 310 QTYHDPNDE-PEGEPIPPSFFEF 331 DPN + P G P+ F F Sbjct: 351 DELRDPNVKLPNGRDT-PALFNF 372 >3ZDU-A nrPDB Length = 325 Score = 156 bits (395), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 95/301 (31%), Positives = 156/301 (51%), Gaps = 34/301 (11%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR--TLREIKILKHFKHENIITIFN 76 +GEG+YG V HK TG+IVAIK +++P ++ +REIK LK F HEN++ + Sbjct: 11 VGEGSYGTVMKCKHKNTGQIVAIKIF--YERPEQSVNKIAMREIKFLKQFHHENLVNLIE 68 Query: 77 IQRPDSFENFNEVYIIQELMQTDLHRVIS-----TQMLSDDHIQYFIYQTLRAVKVLHGS 131 + F +++++ E + H V+ L ++ +++Q LRA+ LH + Sbjct: 69 V-----FRQKKKIHLVFEFID---HTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 120 Query: 132 NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 N+IHRD+KP N+L++ + K+CDFG AR + + VATRWYRAP Sbjct: 121 NIIHRDIKPENILVSQSGITKLCDFGFARTL----------AAPGDIYDDEVATRWYRAP 170 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGR---DYRHQLLLIFGIIGTPHSDNDL 248 E++L Y + +D+W+ GC++ E+ P P D H+++L G + +PH N Sbjct: 171 ELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNL-SPHLQNIF 229 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 +SP + +P K +P++N D++ L DPA RI++ + L H Y Sbjct: 230 S--KSPIFAGVVLPQVQHPKNA-RKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEY 286 Query: 309 L 309 Sbjct: 287 F 287 >3EB0-A nrPDB Length = 383 Score = 152 bits (385), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 106/340 (31%), Positives = 163/340 (47%), Gaps = 60/340 (17%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 S + L LG G++G+VC +G+ A+KK+ P + R E+ I+K H Sbjct: 6 SKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKV--LQDPRYKNR---ELDIMKVLDHV 60 Query: 70 NIITIFNI------------QRPDSFENFNE---------------------VYIIQELM 96 NII + + Q PD + +I E + Sbjct: 61 NIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYV 120 Query: 97 QTDLHRVISTQMLSD-----DHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINS-NCD 150 LH+V+ + + S + I +IYQ RAV +H + HRD+KP NLL+NS + Sbjct: 121 PDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT 180 Query: 151 LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCG 210 LK+CDFG A+ + S EP+ Y+ +R+YRAPE+ML + +Y+ ++D+WS G Sbjct: 181 LKLCDFGSAKKLIPS-----EPS------VAYICSRFYRAPELMLGATEYTPSIDLWSIG 229 Query: 211 CILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAP 270 C+ EL L +P+F G QL+ I I+GTP + +R +P E P A Sbjct: 230 CVFGELILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRM--NPHYTEV--RFPTLKAKD 285 Query: 271 LEKMFPRVNPK-GIDLLQRMLVFDPAKRITAKEALEHPYL 309 K+ P P IDLL+++L ++P RI EA+ HP+ Sbjct: 286 WRKILPEGTPSLAIDLLEQILRYEPDLRINPYEAMAHPFF 325 >4E7W-A nrPDB Length = 394 Score = 152 bits (384), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 104/330 (31%), Positives = 170/330 (51%), Gaps = 27/330 (8%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIF-- 75 ++G G++GVV A + E VAIKK+ F R L+ ++I+KH ++ F Sbjct: 47 VIGNGSFGVVFQAKLVESDE-VAIKKV--LQDKRFKNRELQIMRIVKHPNVVDLKAFFYS 103 Query: 76 -NIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVI 134 ++ + F N Y+ + + + H Q + I+ ++YQ LR++ +H + Sbjct: 104 NGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGIC 163 Query: 135 HRDLKPSNLLINSNCD-LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV 193 HRD+KP NLL++ LK+ DFG A+I+ + S Y+ +R+YRAPE+ Sbjct: 164 HRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVS-----------YICSRYYRAPEL 212 Query: 194 MLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIES 253 + + Y+ +D+WS GC++AEL +P+FPG QL+ I ++GTP S ++ + + Sbjct: 213 IFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTP-SREQIKTM-N 270 Query: 254 PRAREYIKSLPMYPAAPLEKMF-PRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTY 312 P E+ P P K+F PR P IDL+ R+L + P+ R+TA EAL HP+ Sbjct: 271 PNYMEH--KFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDEL 328 Query: 313 HDPNDE-PEGEPIPPSFFEFDHYKEALTTK 341 P G +PP F+ KE L+ + Sbjct: 329 RTGEARMPNGRELPPL---FNWTKEELSVR 355 >3GC0-A nrPDB Length = 329 Score = 149 bits (375), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 105/300 (35%), Positives = 156/300 (52%), Gaps = 26/300 (8%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77 LGEG YG V A T E VAIK+I ++ +RE+ +LK +H NII + ++ Sbjct: 42 LGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHRNIIELKSV 101 Query: 78 QRPDSFENFNEVYIIQELMQTDLHRVISTQM-LSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 + + +++I E + DL + + +S I+ F+YQ + V H +HR Sbjct: 102 -----IHHNHRLHLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHSRRCLHR 156 Query: 137 DLKPSNLLIN-SNCD----LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 DLKP NLL++ S+ LK+ DFGLAR P Q T + T WYR P Sbjct: 157 DLKPQNLLLSVSDASETPVLKIGDFGLARAF-------GIPIRQ---FTHEIITLWYRPP 206 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCI 251 E++L S YS ++D+WS CI AE+ ++ P+FPG QL IF ++G P Sbjct: 207 EILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVT 266 Query: 252 ESPRAREYIKSLPMYPAAPLEKMF-PRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 P ++ +S P + L+++ ++ +G+DLL ML DP KRI+AK ALEHPY Sbjct: 267 ALP---DWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFS 323 >3E3P-A nrPDB Length = 360 Score = 147 bits (370), Expect = 9e-36, Method: Compositional matrix adjust. Identities = 107/343 (31%), Positives = 164/343 (47%), Gaps = 50/343 (14%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 FQ++ + G+G +G V K TG VAIKK+ P F R L+ ++ L H NI+ Sbjct: 25 FQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV--IQDPRFRNRELQIMQDLAVLHHPNIV 82 Query: 73 TIFNIQRPDSFENFNEVY--IIQELMQTDLHRVISTQMLSDDH-----IQYFIYQTLRAV 125 + + + ++Y ++ E + LHR I+ F++Q +R++ Sbjct: 83 QLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIRSI 142 Query: 126 KVLH--GSNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 LH NV HRD+KP N+L+N ++ LK+CDFG A+ + S EP Y Sbjct: 143 GCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPS-----EPN------VAY 191 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 + +R+YRAPE++ + Y+ A+D+WS GCI AE+ L PIF G + QL I ++G P Sbjct: 192 ICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCP 251 Query: 243 HSDNDLRCIESPRAREYIKSL-PMYPAAPL--EKMFPRVN----------PKGIDLLQRM 289 +RE ++ L P + L K P N + DLL + Sbjct: 252 -------------SREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSAL 298 Query: 290 LVFDPAKRITAKEALEHPYLQTYHDPNDE-PEGEPIPPSFFEF 331 L + P +R+ EAL HPY HDP + P + +P F F Sbjct: 299 LQYLPEERMKPYEALCHPYFDELHDPATKLPNNKDLPEDLFRF 341 >5X8I-B nrPDB Length = 346 Score = 134 bits (336), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 108/342 (31%), Positives = 162/342 (47%), Gaps = 62/342 (18%) Query: 9 ISSDFQLKSLLGEGAYG-VVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 +S+ +++ LGEGA+G VV HK G VA+K ++ D+ A R+ EI++L+H Sbjct: 11 LSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARS--EIQVLEHLN 68 Query: 68 HENIITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQML---SDDHIQYFIYQTLR 123 + + F +Q + FE+ + I+ EL+ + I DHI+ YQ + Sbjct: 69 TTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICK 128 Query: 124 AVKVLHGSNVIHRDLKPSNLLINS-------------------NCDLKVCDFGLARIIDE 164 +V LH + + H DLKP N+L N D+KV DFG A DE Sbjct: 129 SVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDE 188 Query: 165 SAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFP 224 + V+TR YRAPEV+L + +S+ DVWS GCIL E +L +FP Sbjct: 189 HH-------------STLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFP 234 Query: 225 GRDYRHQLLLIFGIIG-TPHSDNDLRCIESPRAREYI----------KSLPMY---PAAP 270 D + L ++ I+G P I+ R R+Y S Y P Sbjct: 235 THDSKEHLAMMERILGPLPK-----HMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKP 289 Query: 271 LEKMFPRVN---PKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 L++ + + DL+Q+ML +DPAKRIT +EAL+HP+ Sbjct: 290 LKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >4CRL-A nrPDB Length = 406 Score = 127 bits (320), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 97/323 (30%), Positives = 154/323 (47%), Gaps = 46/323 (14%) Query: 19 LGEGAYGVV--CSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFN 76 +G G YG V + A+K+IE ++ REI +L+ KH N+I++ Sbjct: 30 VGRGTYGHVYKAKRKDGKDDKDYALKQIEGTG---ISMSACREIALLRELKHPNVISL-- 84 Query: 77 IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDH----------IQYFIYQTLRAVK 126 Q+ +V+++ + + DL +I S + ++ +YQ L + Sbjct: 85 -QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIH 143 Query: 127 VLHGSNVIHRDLKPSNLLINSNC----DLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 LH + V+HRDLKP+N+L+ +K+ D G AR+ + P + + Sbjct: 144 YLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNS-------PLKPLADLDPV 196 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD--------YRH-QLL 233 V T WYRAPE++L + Y++A+D+W+ GCI AEL PIF R Y H QL Sbjct: 197 VVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLD 256 Query: 234 LIFGIIGTPHSDNDLRCIES-PRAREYIKSL--PMYPAAPL----EKMFPRVNPKGIDLL 286 IF ++G P +D D I+ P +K Y L EK + + K LL Sbjct: 257 RIFNVMGFP-ADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLL 315 Query: 287 QRMLVFDPAKRITAKEALEHPYL 309 Q++L DP KRIT+++A++ PY Sbjct: 316 QKLLTMDPIKRITSEQAMQDPYF 338 >2YCR-A nrPDB Length = 323 Score = 127 bits (320), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 103/319 (32%), Positives = 157/319 (49%), Gaps = 64/319 (20%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLRE--------- 59 + ++ + LG GA G V A + T + VAIK I K FA+ + RE Sbjct: 8 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKII---SKRKFAIGSAREADPALNVET 64 Query: 60 -IKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQY 116 I+ILK H II I N F + + YI+ ELM+ +V+ + L + + Sbjct: 65 EIEILKKLNHPCIIKIKN------FFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKL 118 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPT 173 + YQ L AV+ LH + +IHRDLKP N+L++S +C +K+ DFG ++I+ Sbjct: 119 YFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL----------- 167 Query: 174 GQQSGMTEYVATRWYRAPEVMLT--SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQ 231 G+ S M T Y APEV+++ +A Y+RA+D WS G IL P P ++R Q Sbjct: 168 GETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYP--PFSEHRTQ 225 Query: 232 LLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLV 291 + L ++ I S Y P +++ V+ K +DL++++LV Sbjct: 226 VSL----------------------KDQITS-GKYNFIP--EVWAEVSEKALDLVKKLLV 260 Query: 292 FDPAKRITAKEALEHPYLQ 310 DP R T +EAL HP+LQ Sbjct: 261 VDPKARFTTEEALRHPWLQ 279 >3I6U-A nrPDB Length = 419 Score = 127 bits (318), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 102/319 (31%), Positives = 157/319 (49%), Gaps = 64/319 (20%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLRE--------- 59 + ++ + LG GA G V A + T + VAI+ I K FA+ + RE Sbjct: 133 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRII---SKRKFAIGSAREADPALNVET 189 Query: 60 -IKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQY 116 I+ILK H II I N F + + YI+ ELM+ +V+ + L + + Sbjct: 190 EIEILKKLNHPCIIKIKN------FFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKL 243 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPT 173 + YQ L AV+ LH + +IHRDLKP N+L++S +C +K+ DFG ++I+ Sbjct: 244 YFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL----------- 292 Query: 174 GQQSGMTEYVATRWYRAPEVMLT--SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQ 231 G+ S M T Y APEV+++ +A Y+RA+D WS G IL P P ++R Q Sbjct: 293 GETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYP--PFSEHRTQ 350 Query: 232 LLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLV 291 + L ++ I S Y P +++ V+ K +DL++++LV Sbjct: 351 VSL----------------------KDQITS-GKYNFIP--EVWAEVSEKALDLVKKLLV 385 Query: 292 FDPAKRITAKEALEHPYLQ 310 DP R T +EAL HP+LQ Sbjct: 386 VDPKARFTTEEALRHPWLQ 404 >5Y86-A nrPDB Length = 588 Score = 126 bits (317), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 96/334 (28%), Positives = 162/334 (48%), Gaps = 57/334 (17%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +++ ++G+G++G V + VA+K + ++ F + EI+IL+H K ++ Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKRFHRQAAEEIRILEHLKKQDKT 266 Query: 73 TIFN-IQRPDSFENFNEVYIIQELMQTDLHRVIST---QMLSDDHIQYFIYQTLRAVKVL 128 N I +SF N V + EL+ DL+ +I Q S ++ F L+++ L Sbjct: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 Query: 129 HGSNVIHRDLKPSNLLI--NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H + +IH DLKP N+L+ + KV DFG + + + Y+ +R Sbjct: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF-------------EYQKLYTYIQSR 373 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 +YRAPE++L S +YS +D+WS GCILAEL +P+FPG D QL + ++G P Sbjct: 374 FYRAPEIILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPP-- 430 Query: 247 DLRCIE-SPRAREYI--KSLPMYPAAPLE------------KMFPRVNPKG--------- 282 + +E S RA+ +I K +P Y + + + + P G Sbjct: 431 --KLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALK 488 Query: 283 -------IDLLQRMLVFDPAKRITAKEALEHPYL 309 I+ L+R L +DP+ R+T +AL HP++ Sbjct: 489 GCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 >3NCG-A nrPDB Length = 486 Score = 125 bits (313), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 88/305 (28%), Positives = 137/305 (44%), Gaps = 50/305 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRT-LREIKILKHFKHENI 71 + + +LG+G++G V + T + A+K I T LRE+++LK H NI Sbjct: 24 YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNI 83 Query: 72 ITIFNI-QRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHG 130 + +F I + SF E+Y EL +I + S+ I Q + +H Sbjct: 84 MKLFEILEDSSSFYIVGELYTGGEL----FDEIIKRKRFSEHDAARIIKQVFSGITYMHK 139 Query: 131 SNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 N++HRDLKP N+L+ S +CD+K+ DFGL+ Q + M + + T + Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQ-----------QNTKMKDRIGTAY 188 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APEV+ Y DVWS G IL L P F G+ N+ Sbjct: 189 YIAPEVL--RGTYDEKCDVWSAGVILYILLSGTPPFYGK-------------------NE 227 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 ++ +Y LP + ++ DL+++ML F P+ RITA + LEHP Sbjct: 228 YDILKRVETGKYAFDLPQWRT---------ISDDAKDLIRKMLTFHPSLRITATQCLEHP 278 Query: 308 YLQTY 312 ++Q Y Sbjct: 279 WIQKY 283 >3DFA-A nrPDB Length = 286 Score = 124 bits (312), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 88/305 (28%), Positives = 137/305 (44%), Gaps = 50/305 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRT-LREIKILKHFKHENI 71 + + +LG+G++G V + T + A+K I T LRE+++LK H NI Sbjct: 24 YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNI 83 Query: 72 ITIFNI-QRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHG 130 + +F I + SF E+Y EL +I + S+ I Q + +H Sbjct: 84 MKLFEILEDSSSFYIVGELYTGGELFD----EIIKRKRFSEHDAARIIKQVFSGITYMHK 139 Query: 131 SNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 N++HRDLKP N+L+ S +CD+K+ DFGL+ Q + M + + T + Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQ-----------QNTKMKDRIGTAY 188 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APEV+ Y DVWS G IL L P F G+ N+ Sbjct: 189 YIAPEVL--RGTYDEKCDVWSAGVILYILLSGTPPFYGK-------------------NE 227 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 ++ +Y LP + ++ DL+++ML F P+ RITA + LEHP Sbjct: 228 YDILKRVETGKYAFDLPQWRT---------ISDDAKDLIRKMLTFHPSLRITATQCLEHP 278 Query: 308 YLQTY 312 ++Q Y Sbjct: 279 WIQKY 283 >6FYV-A nrPDB Length = 337 Score = 122 bits (307), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 103/341 (30%), Positives = 158/341 (46%), Gaps = 60/341 (17%) Query: 9 ISSDFQLKSLLGEGAYG-VVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 + + +++ LGEGA+G VV H G VA+K ++ + A R+ EI++L+H Sbjct: 12 LRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARS--EIQVLEHLN 69 Query: 68 HENIITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQML---SDDHIQYFIYQTLR 123 + ++F +Q + F++ V I+ EL+ + I DHI+ YQ + Sbjct: 70 STDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQ 129 Query: 124 AVKVLHGSNVIHRDLKPSNLLI---------NS----------NCDLKVCDFGLARIIDE 164 ++ LH + + H DLKP N+L NS N D+KV DFG A DE Sbjct: 130 SINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDE 189 Query: 165 SAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFP 224 + V+TR YRAPEV+L + +S+ DVWS GCIL E +L +F Sbjct: 190 HHS-------------TLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQ 235 Query: 225 GRDYRHQLLLIFGIIG-TPHS------------DNDLRCIESPRAREYIKSLPMYPAAPL 271 D + L ++ I+G P N L E A Y++ PL Sbjct: 236 THDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRR----RCKPL 291 Query: 272 EKMF---PRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 ++ + K DL++RML +DP +RIT EAL+HP+ Sbjct: 292 KEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF 332 >5XVU-A nrPDB Length = 332 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 69/209 (33%), Positives = 111/209 (53%), Gaps = 18/209 (8%) Query: 109 LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAA 167 +D I+Y+IYQ L+A+ H ++HRD+KP N++I+ N +++ +GLA Sbjct: 122 FTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYH---- 177 Query: 168 DNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL-FLRRPIFPGR 226 GQ+ + VA+R+Y+ PE+++ Y ++D+WS GC+LA + F + P F G Sbjct: 178 -----PGQEYNVR--VASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGH 230 Query: 227 DYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVN-----PK 281 D QL+ I ++GT L+ Y+ L Y P + N + Sbjct: 231 DNYDQLVKIAKVLGTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDE 290 Query: 282 GIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 IDL+ +ML++D AKRI KEA+EHPY + Sbjct: 291 VIDLIDKMLIYDHAKRIAPKEAMEHPYFR 319 >5ZTN-A nrPDB Length = 429 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 93/339 (27%), Positives = 160/339 (47%), Gaps = 55/339 (16%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 +++ +++ ++G+G++G V A + VA+K + ++ F + EI+IL+H + Sbjct: 94 HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVR--NEKRFHRQAAEEIRILEHLR 151 Query: 68 HENIITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVIST---QMLSDDHIQYFIYQTLR 123 ++ N I ++F N + + EL+ +L+ +I Q S ++ F + L+ Sbjct: 152 KQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQ 211 Query: 124 AVKVLHGSNVIHRDLKPSNLLI--NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 + LH + +IH DLKP N+L+ +KV DFG + + Sbjct: 212 CLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG-------------SSCYEHQRVYT 258 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 Y+ +R+YRAPEV+L A+Y +D+WS GCILAEL P+ PG D QL + ++G Sbjct: 259 YIQSRFYRAPEVIL-GARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 317 Query: 242 PHSDNDLRCIESPRAREYI--KSLPMYPAA-----------------------PLEKMFP 276 P S L S RA+ ++ K P Y P + + Sbjct: 318 P-SQKLLDA--SKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWG 374 Query: 277 RV-----NPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 +P +D L++ L +DPA R+T +AL HP+L+ Sbjct: 375 NALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR 413 >6O6Q-A nrPDB Length = 335 Score = 117 bits (292), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 91/322 (28%), Positives = 156/322 (48%), Gaps = 46/322 (14%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILK 64 I +N ++++ LG G Y V E V IK ++P + + REI ILK Sbjct: 35 IKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRK----KIKREISILK 90 Query: 65 HF-KHENIITIFNIQR-PDS------FENFNEVYIIQELMQTDLHRVISTQMLSDDHIQY 116 + NII + ++ R P S FE+ N + D + T +D I++ Sbjct: 91 NLVDGPNIIAMLDVVREPQSKTPGLIFEHINNI---------DFRSLYPT--FTDYDIRF 139 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 ++Y+ L+A+ H ++HRD+KP N++I+ D L R+ID A+ P Sbjct: 140 YMYELLKALDYSHSMGIMHRDVKPHNVMIDH-------DKKLLRLIDWGLAEYYHPG--- 189 Query: 177 SGMTEY---VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL-FLRRPIFPGRDYRHQL 232 TEY VA+R+++ PE+++ Y ++D+WS GC+LA + F++ P F G+ QL Sbjct: 190 ---TEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQL 246 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR-----VNPKGIDLLQ 287 + I ++G+ + L EY + + Y + V+ + +DL+ Sbjct: 247 VQIVRVLGSKNFKKYLEKYNISLGEEY-EDIGYYNKRQWVRFMNENNKDLVSQEFLDLID 305 Query: 288 RMLVFDPAKRITAKEALEHPYL 309 R+L +D +R+TAKEA++H Y Sbjct: 306 RLLRYDHQERLTAKEAMKHAYF 327 >5JN2-A nrPDB Length = 525 Score = 116 bits (290), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 88/313 (28%), Positives = 143/313 (45%), Gaps = 59/313 (18%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI------EPFDKPLFALRTLREIKIL 63 S ++ + +LG+G++G V K TG+ A+K I + DK LRE+++L Sbjct: 66 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESL----LREVQLL 121 Query: 64 KHFKHENIITIFNI-QRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTL 122 K H NI+ ++ + F EVY EL +IS + S+ I Q L Sbjct: 122 KQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGEL----FDEIISRKRFSEVDAARIIRQVL 177 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 + +H + ++HRDLKP NLL+ S + ++++ DFGL+ + S M Sbjct: 178 SGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKK-----------M 226 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 + + T +Y APEV+ Y DVWS G IL L P F G Sbjct: 227 KDKIGTAYYIAPEVL--HGTYDEKCDVWSTGVILYILLSGCPPFNGA------------- 271 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 N+ ++ +Y LP + +V+ DL+++ML + P+ RI+ Sbjct: 272 ------NEYDILKKVEKGKYTFELPQWK---------KVSESAKDLIRKMLTYVPSMRIS 316 Query: 300 AKEALEHPYLQTY 312 A++AL+H ++QTY Sbjct: 317 ARDALDHEWIQTY 329 >6HMD-A nrPDB Length = 365 Score = 115 bits (288), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 68/220 (30%), Positives = 116/220 (52%), Gaps = 38/220 (17%) Query: 107 QMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDES 165 Q+L+D I++++Y+ L+A+ H ++HRD+KP N++I+ L++ D+GLA + Sbjct: 142 QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA 201 Query: 166 AADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRR-PIFP 224 N VA+R+++ PE+++ Y ++D+WS GC+LA + RR P F Sbjct: 202 QEYNVR-----------VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFH 250 Query: 225 GRDYRHQLLLIFGIIGT---------------PHSDNDLRCIESPRAREYIKSLPMYPAA 269 G+D QL+ I ++GT PH ++ L R +I S + Sbjct: 251 GQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRH--- 307 Query: 270 PLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 V+P+ +DLL ++L +D +R+TAKEA+EHPY Sbjct: 308 -------LVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 340 >3MA6-A nrPDB Length = 298 Score = 115 bits (288), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 86/314 (27%), Positives = 144/314 (45%), Gaps = 61/314 (19%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI------EPFDKPLFALRTLREIKIL 63 S ++ + +LG+G++G V K TG+ A+K I + DK LRE+++L Sbjct: 31 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESL----LREVQLL 86 Query: 64 KHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQT 121 K H NI+ ++ FE+ Y++ E+ +IS + S+ I Q Sbjct: 87 KQLDHPNIMKLYEF-----FEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQV 141 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 L + +H + ++HRDLKP NLL+ S + ++++ DFGL+ + S Sbjct: 142 LSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKK----------- 190 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGI 238 M + + T +Y APEV+ Y DVWS G IL L P F G Sbjct: 191 MKDKIGTAYYIAPEVL--HGTYDEKCDVWSTGVILYILLSGCPPFNGA------------ 236 Query: 239 IGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI 298 N+ ++ +Y LP + +V+ DL+++ML + P+ RI Sbjct: 237 -------NEYDILKKVEKGKYTFELPQWK---------KVSESAKDLIRKMLTYVPSMRI 280 Query: 299 TAKEALEHPYLQTY 312 +A++AL+H ++QTY Sbjct: 281 SARDALDHEWIQTY 294 >3BHH-A nrPDB Length = 295 Score = 113 bits (282), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 90/313 (28%), Positives = 145/313 (46%), Gaps = 60/313 (19%) Query: 8 NISSDFQLKSLLGEGAYGVV------CSATHKPTGEIVAIKKIEPFDKPLFALRTLREIK 61 +++ ++QL +G+GA+ VV C+ H+ +I+ KK+ D + RE + Sbjct: 1 SMTDEYQLYEDIGKGAFSVVRRCVKLCTG-HEYAAKIINTKKLSARDHQ----KLEREAR 55 Query: 62 ILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIY 119 I + KH NI+ + + + F Y++ +L+ +++ + S+ + I Sbjct: 56 ICRLLKHSNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADASHCIQ 110 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQ 176 Q L AV H V+HRDLKP NLL+ S C +K+ DFGLA E G Q Sbjct: 111 QILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA----------IEVQGDQ 160 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 + T Y +PEV+ A Y + +D+W+CG IL L + P F D +H+L Sbjct: 161 QAWFGFAGTPGYLSPEVLRKEA-YGKPVDIWACGVILYILLVGYPPFWDED-QHKLY--- 215 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAK 296 + +A Y P + V P+ +L+ +ML +PAK Sbjct: 216 ---------------QQIKAGAYDFPSPEWDT---------VTPEAKNLINQMLTINPAK 251 Query: 297 RITAKEALEHPYL 309 RITA EAL+HP++ Sbjct: 252 RITAHEALKHPWV 264 >4MVF-A nrPDB Length = 506 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 81/296 (27%), Positives = 133/296 (44%), Gaps = 52/296 (17%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 LG+G YG V K T ++ AIK+ E D+ R +EI+I+K H NI+ ++ Sbjct: 65 LGQGTYGCVYKGIDKVTNQLYAIKE-EKKDRLKNINRFFQEIEIMKKLDHPNIVKLY--- 120 Query: 79 RPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 +++EN N +Y+I EL +I ++ + + Q A+ LH N++HR Sbjct: 121 --ETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVHR 178 Query: 137 DLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV 193 DLKP N L N + LK+ DFGL++ + G T T +Y AP+V Sbjct: 179 DLKPENFLFQSENKDSLLKIIDFGLSKNL-----------GTGEFTTTKAGTPYYVAPQV 227 Query: 194 MLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIES 253 + KY + D+WS G I+ L P F G D D ++ Sbjct: 228 L--DGKYDKKCDIWSSGVIMYTLLCGYPPFYG-------------------DTDNEVLKK 266 Query: 254 PRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 + E+ E + ++ +L+ ++L ++P +R T +EAL HP++ Sbjct: 267 VKKGEF---------CFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWI 313 >2V7O-A nrPDB Length = 336 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 91/310 (29%), Positives = 145/310 (46%), Gaps = 58/310 (18%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHK-PTGE----IVAIKKIEPFDKPLFALRTLREIKILK 64 + D+QL LG+GA+ VV K PT E I+ KK+ D + RE +I + Sbjct: 30 TDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQ----KLEREARICR 85 Query: 65 HFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTL 122 KH NI+ + + + F Y++ +L+ +++ + S+ + I+Q L Sbjct: 86 LLKHPNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADASHCIHQIL 140 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGM 179 +V +H +++HRDLKP NLL+ S C +K+ DFGLA E G+Q Sbjct: 141 ESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA----------IEVQGEQQAW 190 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 + T Y +PEV L Y + +D+W+CG IL L + P F D +H+L Sbjct: 191 FGFAGTPGYLSPEV-LRKDPYGKPVDIWACGVILYILLVGYPPFWDED-QHKLY------ 242 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 + +A Y P + V P+ +L+ +ML +PAKRIT Sbjct: 243 ------------QQIKAGAYDFPSPEWDT---------VTPEAKNLINQMLTINPAKRIT 281 Query: 300 AKEALEHPYL 309 A +AL+HP++ Sbjct: 282 ADQALKHPWV 291 >4RGJ-A nrPDB Length = 520 Score = 112 bits (280), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 83/301 (27%), Positives = 138/301 (45%), Gaps = 54/301 (17%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEP--FDKPLFALRTLREIKILKHFKHENIITIF 75 +LG+G++G V + K TG AIK I + LRE+++LK H NI+ ++ Sbjct: 67 ILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLY 126 Query: 76 NIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNV 133 FE+ N Y++ ++ +IS + + I Q L + +H +NV Sbjct: 127 EF-----FEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNV 181 Query: 134 IHRDLKPSNLLINSNCD----LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 +HRDLKP N+L+ + +K+ DFGL+ + S M + + T +Y Sbjct: 182 VHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKK-----------MKDKIGTAYYI 230 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLR 249 AP+V+ Y D+WSCG IL L P F G N+ Sbjct: 231 APDVL--HGTYDEKCDIWSCGVILYILLSGCPPFNGS-------------------NEYD 269 Query: 250 CIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 ++ A +Y LP F +++ K DL+++ML++ A RI+A++ALEH ++ Sbjct: 270 ILKKVEAGKYTFDLP---------QFKKISDKAKDLIKKMLMYTSAVRISARDALEHEWI 320 Query: 310 Q 310 + Sbjct: 321 K 321 >4JDH-A nrPDB Length = 346 Score = 112 bits (279), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 84/301 (27%), Positives = 151/301 (50%), Gaps = 53/301 (17%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +GEG+ G+VC AT + +G++VA+KK++ + L E+ I++ ++HEN++ ++N Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL-LFNEVVIMRDYQHENVVEMYN-- 138 Query: 79 RPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 S+ +E++++ E ++ L +++ ++++ I L+A+ VLH VIHRD Sbjct: 139 ---SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 195 Query: 138 LKPSNLLINSNCDLKVCDFGL-ARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 +K ++L+ + +K+ DFG A++ E S V T ++ APE +++ Sbjct: 196 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKS-----------LVGTPYWMAPE-LIS 243 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESP-R 255 Y +D+WS G ++ E+ + G P N E P + Sbjct: 244 RLPYGPEVDIWSLGIMVIEM---------------------VDGEPPYFN-----EPPLK 277 Query: 256 AREYIK-SLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHD 314 A + I+ +LP P K +V+P L R+LV DPA+R TA E L+HP+L Sbjct: 278 AMKMIRDNLP-----PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGP 332 Query: 315 P 315 P Sbjct: 333 P 333 >2Q0N-A nrPDB Length = 301 Score = 112 bits (279), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 84/301 (27%), Positives = 151/301 (50%), Gaps = 53/301 (17%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +GEG+ G+VC AT + +G++VA+KK++ + L E+ I++ ++HEN++ ++N Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL-LFNEVVIMRDYQHENVVEMYN-- 93 Query: 79 RPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 S+ +E++++ E ++ L +++ ++++ I L+A+ VLH VIHRD Sbjct: 94 ---SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 150 Query: 138 LKPSNLLINSNCDLKVCDFGL-ARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 +K ++L+ + +K+ DFG A++ E S V T ++ APE +++ Sbjct: 151 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKS-----------LVGTPYWMAPE-LIS 198 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESP-R 255 Y +D+WS G ++ E+ + G P N E P + Sbjct: 199 RLPYGPEVDIWSLGIMVIEM---------------------VDGEPPYFN-----EPPLK 232 Query: 256 AREYIK-SLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHD 314 A + I+ +LP P K +V+P L R+LV DPA+R TA E L+HP+L Sbjct: 233 AMKMIRDNLP-----PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGP 287 Query: 315 P 315 P Sbjct: 288 P 288 >4FIE-A nrPDB Length = 423 Score = 112 bits (279), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 84/301 (27%), Positives = 151/301 (50%), Gaps = 53/301 (17%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +GEG+ G+VC AT + +G++VA+KK++ + L E+ I++ ++HEN++ ++N Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL-LFNEVVIMRDYQHENVVEMYN-- 215 Query: 79 RPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 S+ +E++++ E ++ L +++ ++++ I L+A+ VLH VIHRD Sbjct: 216 ---SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 272 Query: 138 LKPSNLLINSNCDLKVCDFGL-ARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 +K ++L+ + +K+ DFG A++ E S V T ++ APE +++ Sbjct: 273 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKS-----------LVGTPYWMAPE-LIS 320 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESP-R 255 Y +D+WS G ++ E+ + G P N E P + Sbjct: 321 RLPYGPEVDIWSLGIMVIEM---------------------VDGEPPYFN-----EPPLK 354 Query: 256 AREYIK-SLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHD 314 A + I+ +LP P K +V+P L R+LV DPA+R TA E L+HP+L Sbjct: 355 AMKMIRDNLP-----PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGP 409 Query: 315 P 315 P Sbjct: 410 P 410 >6EII-A nrPDB Length = 352 Score = 111 bits (278), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 70/231 (30%), Positives = 125/231 (54%), Gaps = 26/231 (11%) Query: 91 IIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN-SNC 149 + + + TD ++ T L+D I++++Y+ L+A+ H ++HRD+KP N++I+ + Sbjct: 135 VFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR 192 Query: 150 DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSC 209 L++ D+GLA GQ+ + VA+R+++ PE+++ Y ++D+WS Sbjct: 193 KLRLIDWGLAEFYH---------PGQEYNVR--VASRYFKGPELLVDYQMYDYSLDMWSL 241 Query: 210 GCILAELFLRR-PIFPGRDYRHQLLLIFGIIGTP--HSDNDLRCIE-SPR-----AREYI 260 GC+LA + R+ P F G D QL+ I ++GT + D IE PR R Sbjct: 242 GCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSR 301 Query: 261 KSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQT 311 K + + + + V+P+ +D L ++L +D R+TA+EA+EHPY T Sbjct: 302 KRWERFVHSENQHL---VSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYT 349 >4XBR-A nrPDB Length = 366 Score = 111 bits (278), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 83/300 (27%), Positives = 152/300 (50%), Gaps = 51/300 (17%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +GEG+ G+VC AT + +G++VA+KK++ + L E+ I++ ++HEN++ ++N Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL-LFNEVVIMRDYQHENVVEMYN-- 158 Query: 79 RPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 S+ +E++++ E ++ L +++ ++++ I L+A+ VLH VIHRD Sbjct: 159 ---SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 215 Query: 138 LKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTS 197 +K ++L+ + +K+ DFG A S+ ++ + V T ++ APE +++ Sbjct: 216 IKSDSILLTHDGRVKLSDFGF-------CAQVSKEVPRRKSL---VGTPYWMAPE-LISR 264 Query: 198 AKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESP-RA 256 Y +D+WS G ++ E+ + G P N E P +A Sbjct: 265 LPYGPEVDIWSLGIMVIEM---------------------VDGEPPYFN-----EPPLKA 298 Query: 257 REYIK-SLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDP 315 + I+ +LP P K +V+P L R+LV DPA+R TA E L+HP+L P Sbjct: 299 MKMIRDNLP-----PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 353 >2VN9-A nrPDB Length = 301 Score = 110 bits (276), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 90/312 (28%), Positives = 143/312 (45%), Gaps = 58/312 (18%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGE-----IVAIKKIEPFDKPLFALRTLREIKI 62 +++ ++QL LG+GA+ VV PTG+ I+ KK+ D + RE +I Sbjct: 1 SMTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQ----KLEREARI 56 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQ 120 + KH NI+ + + + F Y++ +L+ +++ + S+ + I Q Sbjct: 57 CRLLKHPNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADASHCIQQ 111 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQS 177 L +V H + ++HRDLKP NLL+ S +K+ DFGLA E G Q Sbjct: 112 ILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA----------IEVQGDQQ 161 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 + T Y +PEV L Y + +D+W+CG IL L + P F D +H+L Sbjct: 162 AWFGFAGTPGYLSPEV-LRKDPYGKPVDMWACGVILYILLVGYPPFWDED-QHRLY---- 215 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 + +A Y P + V P+ DL+ +ML +PAKR Sbjct: 216 --------------QQIKAGAYDFPSPEWDT---------VTPEAKDLINKMLTINPAKR 252 Query: 298 ITAKEALEHPYL 309 ITA EAL+HP++ Sbjct: 253 ITASEALKHPWI 264 >3LIJ-A nrPDB Length = 494 Score = 110 bits (276), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 93/310 (30%), Positives = 139/310 (44%), Gaps = 54/310 (17%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA-LRTLREIKILKHF 66 ++S +Q LG GAYG V K T AIK I + + L E+ +LK Sbjct: 34 HLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLL 93 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRA 124 H NI+ ++ D FE+ Y++ E + +I ++ I Q L Sbjct: 94 DHPNIMKLY-----DFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSG 148 Query: 125 VKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 V LH N++HRDLKP NLL+ S + +K+ DFGL+ + + Q M E Sbjct: 149 VTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFE-----------NQKKMKE 197 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 + T +Y APEV+ KY DVWS G IL L P F G+ Sbjct: 198 RLGTAYYIAPEVL--RKKYDEKCDVWSIGVILFILLAGYPPFGGQ--------------- 240 Query: 242 PHSDND-LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 +D + LR +E + Y P + V+ DL+++ML FD +RI+A Sbjct: 241 --TDQEILRKVEKGK---YTFDSPEW---------KNVSEGAKDLIKQMLQFDSQRRISA 286 Query: 301 KEALEHPYLQ 310 ++ALEHP+++ Sbjct: 287 QQALEHPWIK 296 >3HZT-A nrPDB Length = 467 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 92/310 (29%), Positives = 142/310 (45%), Gaps = 55/310 (17%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRT--LREIKILKH 65 +S +Q LG GAYG V K TG AIK I+ + L E+ +LK Sbjct: 1 GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 60 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLR 123 H NI+ ++ FE+ Y++ E+ + +I Q S+ + Q L Sbjct: 61 LDHPNIMKLYEF-----FEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLS 115 Query: 124 AVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 LH N++HRDLKP NLL+ S + +K+ DFGL+ + E G+ M Sbjct: 116 GTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSA--------HFEVGGK---MK 164 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 E + T +Y APEV+ KY DVWSCG IL L P F G+ Sbjct: 165 ERLGTAYYIAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQ-------------- 208 Query: 241 TPHSDND-LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 +D + L+ +E + + P + + +V+ + L++ ML ++P+KRI+ Sbjct: 209 ---TDQEILKRVEKGK----------FSFDPPD--WTQVSDEAKQLVKLMLTYEPSKRIS 253 Query: 300 AKEALEHPYL 309 A+EAL HP++ Sbjct: 254 AEEALNHPWI 263 >3DXN-A nrPDB Length = 287 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 92/310 (29%), Positives = 142/310 (45%), Gaps = 55/310 (17%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKH 65 +S +Q LG GAYG V K TG AIK I+ + L E+ +LK Sbjct: 18 GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 77 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLR 123 H NI+ ++ FE+ Y++ E+ + +I Q S+ + Q L Sbjct: 78 LDHPNIMKLYEF-----FEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLS 132 Query: 124 AVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 LH N++HRDLKP NLL+ S + +K+ DFGL+ + E G+ M Sbjct: 133 GTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSA--------HFEVGGK---MK 181 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 E + T +Y APEV+ KY DVWSCG IL L P F G+ Sbjct: 182 ERLGTAYYIAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQ-------------- 225 Query: 241 TPHSDND-LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 +D + L+ +E + + P + + +V+ + L++ ML ++P+KRI+ Sbjct: 226 ---TDQEILKRVEKGK----------FSFDPPD--WTQVSDEAKQLVKLMLTYEPSKRIS 270 Query: 300 AKEALEHPYL 309 A+EAL HP++ Sbjct: 271 AEEALNHPWI 280 >2JC6-A nrPDB Length = 334 Score = 109 bits (273), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 89/317 (28%), Positives = 138/317 (43%), Gaps = 60/317 (18%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR---- 58 K+ +I F+ K LG GA+ V A K TG++ A+K I P AL+ Sbjct: 14 KKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCI-----PKKALKGKESSIE 68 Query: 59 -EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQ 115 EI +L+ KHENI+ + +I +E+ N +Y++ +L+ R++ ++ Sbjct: 69 NEIAVLRKIKHENIVALEDI-----YESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDAS 123 Query: 116 YFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSN---CDLKVCDFGLARIIDESAADNSEP 172 I Q L AV LH ++HRDLKP NLL S + + DFGL+++ Sbjct: 124 TLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM----------- 172 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 G+ M+ T Y APEV L YS+A+D WS G I L P F Sbjct: 173 EGKGDVMSTACGTPGYVAPEV-LAQKPYSKAVDCWSIGVIAYILLCGYPPF--------- 222 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 + +ND + E EY P + ++ D ++ ++ Sbjct: 223 ----------YDENDSKLFEQILKAEYEFDSPYW---------DDISDSAKDFIRNLMEK 263 Query: 293 DPAKRITAKEALEHPYL 309 DP KR T ++A HP++ Sbjct: 264 DPNKRYTCEQAARHPWI 280 >4MD7-E nrPDB Length = 391 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 75/252 (29%), Positives = 134/252 (53%), Gaps = 28/252 (11%) Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 NIIT+ +I + + + + + TD ++ T L+D I++++Y+ L+A+ H Sbjct: 93 NIITLADIVKDPV--SRTPALVFEHVNNTDFKQLYQT--LTDYDIRFYMYEILKALDYCH 148 Query: 130 GSNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 ++HRD+KP N++I+ + L++ D+GLA GQ+ + VA+R++ Sbjct: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYH---------PGQEYNVR--VASRYF 197 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRR-PIFPGRDYRHQLLLIFGIIGTP--HSD 245 + PE+++ Y ++D+WS GC+LA + R+ P F G D QL+ I ++GT + Sbjct: 198 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY 257 Query: 246 NDLRCIE-SPR-----AREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 D IE PR R K + + + + V+P+ +D L ++L +D R+T Sbjct: 258 IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHL---VSPEALDFLDKLLRYDHQSRLT 314 Query: 300 AKEALEHPYLQT 311 A+EA+EHPY T Sbjct: 315 AREAMEHPYFYT 326 >5FG8-A nrPDB Length = 285 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 89/310 (28%), Positives = 141/310 (45%), Gaps = 58/310 (18%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTG-----EIVAIKKIEPFDKPLFALRTLREIKILK 64 S ++ +K LG+GA+ +V K TG +I+ KK+ D + RE +I + Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQ----KLEREARICR 68 Query: 65 HFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTL 122 H NI+ + DS + N Y++ +L+ +++ + S+ + I Q L Sbjct: 69 KLHHPNIVRLH-----DSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQIL 123 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGM 179 +V H + V+HRDLKP NLL+ S +K+ DFGLA E G Sbjct: 124 ESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLA----------IEVQGDHQAW 173 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 + T Y +PEV L Y +++D+W+CG IL L + P F D +H+L + I Sbjct: 174 FGFAGTPGYLSPEV-LKKEPYGKSVDIWACGVILYILLVGYPPFWDED-QHRL---YSQI 228 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 D YP+ + V P+ +L+ +ML +P KRIT Sbjct: 229 KAGAYD--------------------YPSPEWDT----VTPEAKNLINQMLTVNPNKRIT 264 Query: 300 AKEALEHPYL 309 A EAL+HP++ Sbjct: 265 AAEALKHPWI 274 >2PVN-A nrPDB Length = 352 Score = 108 bits (270), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 72/248 (29%), Positives = 122/248 (49%), Gaps = 22/248 (8%) Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 NI+ + +I R + I + + TD + T L+D I+Y+IY+ L+A+ H Sbjct: 108 NIVKLLDIVRDQHSKT--PSLIFEYVNNTDFKVLYPT--LTDYDIRYYIYELLKALDYCH 163 Query: 130 GSNVIHRDLKPSNLLINSNC-DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 ++HRD+KP N++I+ L++ D+GLA N VA+R++ Sbjct: 164 SQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVR-----------VASRYF 212 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRR-PIFPGRDYRHQLLLIFGIIGTPHSD-- 245 + PE+++ Y ++D+WS GC+ A + R+ P F G D QL+ I ++GT + Sbjct: 213 KGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAY 272 Query: 246 -NDLRCIESPRAREYIKSLPMYPAAPLEKMFPR--VNPKGIDLLQRMLVFDPAKRITAKE 302 N R P+ + P + V+P+ ID L ++L +D +R+TA E Sbjct: 273 LNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALE 332 Query: 303 ALEHPYLQ 310 A+ HPY Q Sbjct: 333 AMTHPYFQ 340 >1PHK-A nrPDB Length = 298 Score = 107 bits (268), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 90/317 (28%), Positives = 147/317 (46%), Gaps = 60/317 (18%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA------LR--TLREIKIL 63 +++ K +LG G VV HKPT + A+K I+ F+ LR TL+E+ IL Sbjct: 18 NYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDIL 77 Query: 64 KHFK-HENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQM-LSDDHIQYFIYQ 120 + H NII Q D++E +++ +LM+ +L ++ ++ LS+ + + Sbjct: 78 RKVSGHPNII-----QLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRA 132 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 L + LH N++HRDLKP N+L++ + ++K+ DFG + +D + Sbjct: 133 LLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEK-----------LR 181 Query: 181 EYVATRWYRAPEVMLTSAK-----YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLI 235 E T Y APE++ S Y + +D+WS G I+ L P F +R Q+L++ Sbjct: 182 EVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFW---HRKQMLML 238 Query: 236 FGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPA 295 I+ + SP +Y ++ DL+ R LV P Sbjct: 239 RMIMSGNYQ------FGSPEWDDYSDTVK-------------------DLVSRFLVVQPQ 273 Query: 296 KRITAKEALEHPYLQTY 312 KR TA+EAL HP+ Q Y Sbjct: 274 KRYTAEEALAHPFFQQY 290 >4FG9-A nrPDB Length = 320 Score = 107 bits (267), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 84/309 (27%), Positives = 139/309 (44%), Gaps = 54/309 (17%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKH 65 +I + + +LG GA+ V A K T ++VAIK I E + ++ EI +L Sbjct: 15 DIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMEN--EIAVLHK 72 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLR 123 KH NI+ + +I +E+ +Y+I +L+ R++ ++ I+Q L Sbjct: 73 IKHPNIVALDDI-----YESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLD 127 Query: 124 AVKVLHGSNVIHRDLKPSNLL---INSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 AVK LH ++HRDLKP NLL ++ + + + DFGL+++ D + ++ Sbjct: 128 AVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSV-----------LS 176 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 T Y APEV L YS+A+D WS G I L P F Sbjct: 177 TACGTPGYVAPEV-LAQKPYSKAVDCWSIGVIAYILLCGYPPF----------------- 218 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 + +ND + E EY P + ++ D ++ ++ DP KR T Sbjct: 219 --YDENDAKLFEQILKAEYEFDSPYW---------DDISDSAKDFIRHLMEKDPEKRFTC 267 Query: 301 KEALEHPYL 309 ++AL+HP++ Sbjct: 268 EQALQHPWI 276 >2JAM-A nrPDB Length = 304 Score = 107 bits (266), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 87/309 (28%), Positives = 137/309 (44%), Gaps = 56/309 (18%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-EIKILKHF 66 NI F +LG GA+ V + TG++ A+K I+ P F +L EI +LK Sbjct: 6 NIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIK--KSPAFRDSSLENEIAVLKKI 63 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRA 124 KHENI+T+ D +E+ Y++ +L+ R++ + ++ I Q L A Sbjct: 64 KHENIVTL-----EDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSA 118 Query: 125 VKVLHGSNVIHRDLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQSG-MT 180 VK LH + ++HRDLKP NLL N + + DFGL+++ +Q+G M+ Sbjct: 119 VKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM-------------EQNGIMS 165 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 T Y APEV L YS+A+D WS G I L P F Sbjct: 166 TACGTPGYVAPEV-LAQKPYSKAVDCWSIGVITYILLCGYPPF----------------- 207 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 + + + + E + Y P + ++ D + +L DP +R T Sbjct: 208 --YEETESKLFEKIKEGYYEFESPFW---------DDISESAKDFICHLLEKDPNERYTC 256 Query: 301 KEALEHPYL 309 ++AL HP++ Sbjct: 257 EKALSHPWI 265 >4IAN-A nrPDB Length = 358 Score = 107 bits (266), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 72/226 (31%), Positives = 111/226 (49%), Gaps = 42/226 (18%) Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNSEP 172 ++ + Q A+K+L N++H D+KP N+L+N S LK+CDFG A ADN Sbjct: 137 VRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSA----SHVADND-- 190 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 +T Y+ +R+YRAPE+++ + Y +D+WS GC L EL+ + +FPG+ H L Sbjct: 191 ------ITPYLVSRFYRAPEIIIGKS-YDYGIDMWSVGCTLYELYTGKILFPGKTNNHML 243 Query: 233 LLIF-------------GIIGTPHSDNDLRC--IESPRAREYIKSLPMYPAAPLEKM--- 274 L G+ H D +L IE + E K M P + + Sbjct: 244 KLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLAD 303 Query: 275 ------FPRVNPKGI----DLLQRMLVFDPAKRITAKEALEHPYLQ 310 P K + DLL ++L+ DPAKRI+ +AL+H ++Q Sbjct: 304 LIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQ 349 >2F57-A nrPDB Length = 317 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 80/299 (26%), Positives = 143/299 (47%), Gaps = 47/299 (15%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +GEG+ G+VC AT K TG+ VA+KK++ + L E+ I++ + H+N++ +++ Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRREL-LFNEVVIMRDYHHDNVVDMYS-- 109 Query: 79 RPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 S+ +E++++ E ++ L +++ ++++ I LRA+ LH VIHRD Sbjct: 110 ---SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRD 166 Query: 138 LKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTS 197 +K ++L+ S+ +K+ DFG + + V T ++ APEV ++ Sbjct: 167 IKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK----------SLVGTPYWMAPEV-ISR 215 Query: 198 AKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAR 257 Y +D+WS G ++ E+ I G P N+ R R Sbjct: 216 LPYGTEVDIWSLGIMVIEM---------------------IDGEPPYFNEPPLQAMRRIR 254 Query: 258 EYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 + SLP P K +V+ L MLV +P++R TA+E L HP+L+ P+ Sbjct: 255 D---SLP-----PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPS 305 >3H4J-B nrPDB Length = 336 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 84/316 (26%), Positives = 140/316 (44%), Gaps = 55/316 (17%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKHEN 70 + ++ LGEG++G V ATH T + VA+K I + K +R REI LK +H + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 71 IITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 II +++ I P V +I+ ++ + +++D + F Q + A++ H Sbjct: 71 IIKLYDVITTPTDI-----VMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCH 125 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 ++HRDLKP NLL++ N ++K+ DFGL+ I+ + + E + + Y Sbjct: 126 RHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYA 185 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLR 249 PEV DVWSCG +L + + R P D Sbjct: 186 GPEV-----------DVWSCGIVLYVMLVGR--------------------LPFDD---- 210 Query: 250 CIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 E+I +L + + M ++P L++RM+V DP +RIT +E P+ Sbjct: 211 --------EFIPNLFKKVNSCVYVMPDFLSPGAQSLIRRMIVADPMQRITIQEIRRDPWF 262 Query: 310 QT----YHDPNDEPEG 321 Y P +E +G Sbjct: 263 NVNLPDYLRPMEEVQG 278 >3MN3-A nrPDB Length = 271 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 77/304 (25%), Positives = 136/304 (44%), Gaps = 51/304 (16%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP--FDKPLFALRTLREIKILKHFKH 68 ++Q+ LGEG++G V A H TG+ VA+K I K R REI L+ +H Sbjct: 4 GNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRH 63 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHR-VISTQMLSDDHIQYFIYQTLRAVKV 127 +II ++ D ++ +E+ ++ E +L ++ +S+ + F Q + AV+ Sbjct: 64 PHIIKLY-----DVIKSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEY 118 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H ++HRDLKP NLL++ + ++K+ DFGL+ I+ + + E ++ + Sbjct: 119 CHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKL 178 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y PEV DVWSCG IL + RR F D++ Sbjct: 179 YAGPEV-----------DVWSCGVILYVMLCRRLPF---------------------DDE 206 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 + + +LP + ++P L++RML+ +P RI+ E ++ Sbjct: 207 SIPVLFKNISNGVYTLPKF-----------LSPGAAGLIKRMLIVNPLNRISIHEIMQDD 255 Query: 308 YLQT 311 + + Sbjct: 256 WFKV 259 >2VZ6-A nrPDB Length = 313 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 93/309 (30%), Positives = 139/309 (44%), Gaps = 58/309 (18%) Query: 11 SDFQLKSLLGEGAYGVV--CS---ATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 S +QL LG+GA+ VV C A + +I+ KK+ D + RE +I + Sbjct: 22 SMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQ----KLEREARICRL 77 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLR 123 KH NI+ + DS Y+I +L+ +++ + S+ + I Q L Sbjct: 78 LKHPNIVRLH-----DSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILE 132 Query: 124 AVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 AV H V+HRDLKP NLL+ S +K+ DFGLA E G+Q Sbjct: 133 AVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA----------IEVEGEQQAWF 182 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 + T Y +PEV L Y + +D+W+CG IL L + P F D +H+L Sbjct: 183 GFAGTPGYLSPEV-LRKDPYGKPVDLWACGVILYILLVGYPPFWDED-QHRLY------- 233 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 + +A Y P + V P+ DL+ +ML +P+KRITA Sbjct: 234 -----------QQIKAGAYDFPSPEWDT---------VTPEAKDLINKMLTINPSKRITA 273 Query: 301 KEALEHPYL 309 EAL+HP++ Sbjct: 274 AEALKHPWI 282 >5U6Y-A nrPDB Length = 461 Score = 105 bits (261), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 92/307 (29%), Positives = 138/307 (44%), Gaps = 58/307 (18%) Query: 13 FQLKSLLGEGAYGVV--CS---ATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 +QL LG+GA+ VV C A + +I+ KK+ D + RE +I + K Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQ----KLEREARICRLLK 57 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H NI+ + DS Y+I +L+ +++ + S+ + I Q L AV Sbjct: 58 HPNIVRLH-----DSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAV 112 Query: 126 KVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 H V+HRDLKP NLL+ S +K+ DFGLA E G+Q + Sbjct: 113 LHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA----------IEVEGEQQAWFGF 162 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 T Y +PEV L Y + +D+W+CG IL L + P F D +H+L Sbjct: 163 AGTPGYLSPEV-LRKDPYGKPVDLWACGVILYILLVGYPPFWDED-QHRLY--------- 211 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 + +A Y P + V P+ DL+ +ML +P+KRITA E Sbjct: 212 ---------QQIKAGAYDFPSPEWDT---------VTPEAKDLINKMLTINPSKRITAAE 253 Query: 303 ALEHPYL 309 AL+HP++ Sbjct: 254 ALKHPWI 260 >2Y7J-A nrPDB Length = 365 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 86/310 (27%), Positives = 150/310 (48%), Gaps = 59/310 (19%) Query: 16 KSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR-------TLREIKILKHFK- 67 K ++G G VV H+ TG A+K +E + L + T RE IL+ Sbjct: 99 KDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAG 158 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-LSDDHIQYFIYQTLRAV 125 H +IIT+ DS+E+ + ++++ +LM + +L ++ ++ LS+ + + L AV Sbjct: 159 HPHIITLI-----DSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAV 213 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 LH +N++HRDLKP N+L++ N +++ DFG + + EP G++ + E T Sbjct: 214 SFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHL--------EP-GEK--LRELCGT 262 Query: 186 RWYRAPEVMLTSAK-----YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 Y APE++ S Y + +D+W+CG IL L P F +R Q+L++ I+ Sbjct: 263 PGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFW---HRRQILMLRMIME 319 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 + SP + ++ DL+ R+L DP R+TA Sbjct: 320 GQYQ------FSSPEWDDRSSTVK-------------------DLISRLLQVDPEARLTA 354 Query: 301 KEALEHPYLQ 310 ++AL+HP+ + Sbjct: 355 EQALQHPFFE 364 >2BDW-A nrPDB Length = 362 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 86/310 (27%), Positives = 145/310 (46%), Gaps = 59/310 (19%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTG-----EIVAIKKIEPFDKPLFALRTLREIKILK 64 S ++ +K LG+GA+ VV HK TG +I+ KK+ D + RE +I + Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARD----FQKLEREARICR 83 Query: 65 HFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTL 122 +H NI+ + + + +SF Y++ +L+ +++ + S+ + I Q L Sbjct: 84 KLQHPNIVRLHDSIQEESFH-----YLVFDLVTGGELFEDIVAREFYSEADASHCIQQIL 138 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGM 179 ++ H + ++HR+LKP NLL+ S +K+ DFGLA +++S A + Sbjct: 139 ESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHG--------- 189 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 + T Y +PEV L YS+ +D+W+CG IL L + P F D +H+L + I Sbjct: 190 --FAGTPGYLSPEV-LKKDPYSKPVDIWACGVILYILLVGYPPFWDED-QHRL---YAQI 242 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 D YP+ + V P+ L+ ML +P KRIT Sbjct: 243 KAGAYD--------------------YPSPEWDT----VTPEAKSLIDSMLTVNPKKRIT 278 Query: 300 AKEALEHPYL 309 A +AL+ P++ Sbjct: 279 ADQALKVPWI 288 >5UNP-A nrPDB Length = 369 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 97/333 (29%), Positives = 154/333 (46%), Gaps = 52/333 (15%) Query: 13 FQLKSLLGEGAYG-VVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 +++ S LGEG +G VV H+ G VA+K I+ +K A R EI +L+ ++ Sbjct: 36 YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARL--EINVLEKINEKDP 93 Query: 72 ITI-FNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDH--------IQYFIYQTL 122 +Q D F+ + I EL+ + + L D++ +++ +Q Sbjct: 94 DNKNLCVQMFDWFDYHGHMCISFELLG-----LSTFDFLKDNNYLPYPIHQVRHMAFQLC 148 Query: 123 RAVKVLHGSNVIHRDLKPSNLL-INSNCDLKVCDFGLARIIDESAA--------DNSEPT 173 +AVK LH + + H DLKP N+L +NS+ +L + L + DE + D T Sbjct: 149 QAVKFLHDNKLTHTDLKPENILFVNSDYELT---YNLEKKRDERSVKSTAVRVVDFGSAT 205 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLL 233 + V+TR YRAPEV+L +S+ DVWS GCI+ E ++ +F D R L Sbjct: 206 FDHEHHSTIVSTRHYRAPEVILELG-WSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLA 264 Query: 234 LIFGIIGTPHS-----------------DNDLRCIESPRAREYIKSLPMYPAAPLEKMFP 276 ++ I+G S D D RE K L Y + E+ Sbjct: 265 MMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEE--- 321 Query: 277 RVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 + + DL++ ML ++PAKR+T EAL+HP+ Sbjct: 322 --HHQLFDLIESMLEYEPAKRLTLGEALQHPFF 352 >3KK8-A nrPDB Length = 284 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 86/310 (27%), Positives = 145/310 (46%), Gaps = 59/310 (19%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTG-----EIVAIKKIEPFDKPLFALRTLREIKILK 64 S ++ +K LG+GA+ VV HK TG +I+ KK+ D + RE +I + Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQ----KLEREARICR 60 Query: 65 HFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTL 122 +H NI+ + + + +SF Y++ +L+ +++ + S+ + I Q L Sbjct: 61 KLQHPNIVRLHDSIQEESFH-----YLVFDLVTGGELFEDIVAREFYSEADASHCIQQIL 115 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGM 179 ++ H + ++HR+LKP NLL+ S +K+ DFGLA +++S A + Sbjct: 116 ESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHG--------- 166 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 + T Y +PEV L YS+ +D+W+CG IL L + P F D +H+L + I Sbjct: 167 --FAGTPGYLSPEV-LKKDPYSKPVDIWACGVILYILLVGYPPFWDED-QHRL---YAQI 219 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 D YP+ + V P+ L+ ML +P KRIT Sbjct: 220 KAGAYD--------------------YPSPEWDT----VTPEAKSLIDSMLTVNPKKRIT 255 Query: 300 AKEALEHPYL 309 A +AL+ P++ Sbjct: 256 ADQALKVPWI 265 >4KS7-A nrPDB Length = 292 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 79/292 (27%), Positives = 141/292 (48%), Gaps = 47/292 (16%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +GEG+ G+VC A K +G VA+K ++ + L E+ I++ ++H N++ ++ Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRREL-LFNEVVIMRDYQHFNVVEMYK-- 87 Query: 79 RPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 S+ E++++ E +Q L ++S L+++ I L+A+ LH VIHRD Sbjct: 88 ---SYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRD 144 Query: 138 LKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTS 197 +K ++L+ + +K+ DFG I + G T ++ APEV ++ Sbjct: 145 IKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVG----------TPYWMAPEV-ISR 193 Query: 198 AKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAR 257 + Y+ +D+WS G ++ E+ P + SD+ ++ ++ R Sbjct: 194 SLYATEVDIWSLGIMVIEMVDGEPPY-------------------FSDSPVQAMKRLR-- 232 Query: 258 EYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 S P P K +V+P D L+RMLV DP +R TA+E L+HP+L Sbjct: 233 ---DSPP-----PKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL 276 >3SOA-A nrPDB Length = 444 Score = 104 bits (259), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 90/310 (29%), Positives = 138/310 (44%), Gaps = 58/310 (18%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGE-----IVAIKKIEPFDKPLFALRTLREIKILK 64 + ++QL LG+GA+ VV G+ I+ KK+ D + RE +I + Sbjct: 10 TEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQ----KLEREARICR 65 Query: 65 HFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTL 122 KH NI+ + DS Y+I +L+ +++ + S+ + I Q L Sbjct: 66 LLKHPNIVRLH-----DSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL 120 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 AV H V+HR+LKP NLL+ S +K+ DFGLA E G+Q Sbjct: 121 EAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLA----------IEVEGEQQAW 170 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 + T Y +PEV L Y + +D+W+CG IL L + P F D +H+L Sbjct: 171 FGFAGTPGYLSPEV-LRKDPYGKPVDLWACGVILYILLVGYPPFWDED-QHRLY------ 222 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 + +A Y P + V P+ DL+ +ML +P+KRIT Sbjct: 223 ------------QQIKAGAYDFPSPEWDT---------VTPEAKDLINKMLTINPSKRIT 261 Query: 300 AKEALEHPYL 309 A EAL+HP++ Sbjct: 262 AAEALKHPWI 271 >6FD3-A nrPDB Length = 300 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 83/293 (28%), Positives = 135/293 (46%), Gaps = 47/293 (16%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +G+GA G V +A TG+ VAIK++ +P L + EI +++ K+ NI+ Sbjct: 30 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL-IINEILVMRENKNPNIVNYL--- 85 Query: 79 RPDSFENFNEVYIIQE-LMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 DS+ +E++++ E L L V++ + + I + L+A+ LH + VIHRD Sbjct: 86 --DSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRD 143 Query: 138 LKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTS 197 +K N+L+ + +K+ DFG ++ T +QS + V T ++ APEV +T Sbjct: 144 IKSDNILLGMDGSVKLTDFGFC----------AQITPEQSKRSTMVGTPYWMAPEV-VTR 192 Query: 198 AKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAR 257 Y +D+WS G + E+ P + + L LI GTP N R Sbjct: 193 KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQNPER-------- 243 Query: 258 EYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 L +F D L R L D +R +AKE L+HP+L+ Sbjct: 244 -------------LSAVFR-------DFLNRCLEMDVDRRGSAKELLQHPFLK 276 >4WNO-A nrPDB Length = 287 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 76/228 (33%), Positives = 116/228 (50%), Gaps = 37/228 (16%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEI-VAIKKIEPFDKPLFALRTL--REIKILKHFKH 68 +F K L+G GA+ VV H+ ++ VA+K I K L +TL +EIKILK KH Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCIN--KKNLAKSQTLLGKEIKILKELKH 76 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI-STQMLSDDHIQYFIYQTLRAVK 126 ENI+ +++ Q E N VY++ E DL + + + LS+D I+ F+ Q A++ Sbjct: 77 ENIVALYDFQ-----EMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMR 131 Query: 127 VLHGSNVIHRDLKPSNLLIN---------SNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 +LH +IHRDLKP N+L++ ++ +K+ DFG AR + QS Sbjct: 132 LLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYL-------------QS 178 Query: 178 GM--TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 M + Y APEV++ S Y D+WS G I+ + + F Sbjct: 179 NMMAATLCGSPMYMAPEVIM-SQHYDGKADLWSIGTIVYQCLTGKAPF 225 >6QAU-A nrPDB Length = 280 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 71/226 (31%), Positives = 115/226 (50%), Gaps = 33/226 (14%) Query: 12 DFQLKSLLGEGAYGVVCSATHK-PTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 ++ + L+G GA+ VV H+ T VAIK I + + +EIKILK +HEN Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHEN 71 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQ-MLSDDHIQYFIYQTLRAVKVL 128 I+ ++++Q E N V+++ E DL + + LS+D I+ F++Q A+++L Sbjct: 72 IVALYDVQ-----ELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRIL 126 Query: 129 HGSNVIHRDLKPSNLLIN---------SNCDLKVCDFGLARIIDES--AADNSEPTGQQS 177 H +IHRDLKP N+L++ S +K+ DFG AR + + AAD Sbjct: 127 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAAD--------- 177 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 + Y APEV++ S Y D+WS G ++ + + +P F Sbjct: 178 ----LCGSPMYMAPEVIM-SQHYDAKADLWSIGTVIYQCLVGKPPF 218 >3RAW-A nrPDB Length = 381 Score = 102 bits (254), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 97/333 (29%), Positives = 146/333 (43%), Gaps = 34/333 (10%) Query: 4 RIVYNISSDFQLKSLLGEGAYG-VVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKI 62 RI + +++ LGEG +G VV H VA+K I K A R EI + Sbjct: 44 RIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARL--EINV 101 Query: 63 LKHFKHENIITIF-NIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSD---DHIQYFI 118 LK K ++ F + D F + I EL+ + + H+++ Sbjct: 102 LKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMA 161 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLL-INSNCDL-----KVCDFGLARIIDESAADNSEP 172 YQ A++ LH + + H DLKP N+L +NS + K C+ + AD Sbjct: 162 YQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA 221 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 T T VATR YR PEV+L +++ DVWS GCIL E + +F + R L Sbjct: 222 TFDHEHHTTIVATRHYRPPEVILELG-WAQPCDVWSIGCILFEYYRGFTLFQTHENREHL 280 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYI-KSLPMYPAAPLEKMFPRVNPKGI-------- 283 +++ I+G S I R ++Y K ++ + + + N K + Sbjct: 281 VMMEKILGPIPS----HMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDS 336 Query: 284 -------DLLQRMLVFDPAKRITAKEALEHPYL 309 DL++RML FDPA+RIT EAL HP+ Sbjct: 337 LEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 369 >4CQG-A nrPDB Length = 331 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 86/316 (27%), Positives = 140/316 (44%), Gaps = 51/316 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 ++L +G G + V A H TGE+VAIK ++ R EI LK +H++I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHIC 70 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLHG 130 ++++ E N+++++ E +IS LS++ + Q L AV +H Sbjct: 71 QLYHV-----LETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHS 125 Query: 131 SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS-GMTEYVATRWYR 189 HRDLKP NLL + N LK+ DFGL ++P G + + E + Y Sbjct: 126 QGYAHRDLKPENLLFDENHKLKLIDFGLC----------AKPKGNKDYHLQECCGSLAYA 175 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLR 249 APE++ + DVWS G +L +L+ G + P D+++ Sbjct: 176 APELIQGKSYLGSEADVWSMGILL------------------YVLMCGFL--PFDDDNVM 215 Query: 250 CIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY- 308 + R + +P + ++P I LLQ+ML DP KRI+ + L HP+ Sbjct: 216 ALYKKIMRGKYE-VPKW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWV 263 Query: 309 LQTYHDPNDEPEGEPI 324 +Q Y P + P+ Sbjct: 264 MQDYSCPVEWQSKTPL 279 >4LFI-A nrPDB Length = 374 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 73/254 (28%), Positives = 128/254 (50%), Gaps = 26/254 (10%) Query: 65 HFKHENIITIFNI-QRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLR 123 H H NII +F+I + P S ++ E + R++ + L+D I++++++ L+ Sbjct: 129 HNGHANIIHLFDIIKDPIS----KTPALVFEYVDNVDFRILYPK-LTDLEIRFYMFELLK 183 Query: 124 AVKVLHGSNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 A+ H ++HRD+KP N++I+ N L++ D+GLA + N Sbjct: 184 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR----------- 232 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL-FLRRPIFPGRDYRHQLLLIFGIIGT 241 VA+R+++ PE+++ Y ++D+WS G +LA + F R P F G QL+ I ++GT Sbjct: 233 VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGT 292 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFP------RVNPKGIDLLQRMLVFDPA 295 + L E RE+ + Y P + N + IDL+ +L +D Sbjct: 293 SDFEKYLLKYEITLPREFY-DMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQ 351 Query: 296 KRITAKEALEHPYL 309 +R+TAKEA+ HP+ Sbjct: 352 ERLTAKEAMGHPWF 365 >4JXF-A nrPDB Length = 266 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 82/304 (26%), Positives = 141/304 (46%), Gaps = 53/304 (17%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHFKHE 69 DF++ +LLG+G++ V A TG VAIK I+ K R E+KI KH Sbjct: 8 DFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHP 67 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQM--LSDDHIQYFIYQTLRAVK 126 +I+ ++N FE+ N VY++ E+ +++R + ++ S++ ++F++Q + + Sbjct: 68 SILELYNY-----FEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGML 122 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH ++HRDL SNLL+ N ++K+ DFGLA + + G T Sbjct: 123 YLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCG----------TP 172 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y +PE+ SA + DVWS GC+ L + RP F Sbjct: 173 NYISPEIATRSA-HGLESDVWSLGCMFYTLLIGRPPF----------------------- 208 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 D +++ + + M P+ F + K DL+ ++L +PA R++ L+H Sbjct: 209 DTDTVKNTLNKVVLADYEM-PS------FLSIEAK--DLIHQLLRRNPADRLSLSSVLDH 259 Query: 307 PYLQ 310 P++ Sbjct: 260 PFMS 263 >5IG1-A nrPDB Length = 344 Score = 100 bits (250), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 86/305 (28%), Positives = 143/305 (46%), Gaps = 61/305 (20%) Query: 16 KSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTL------REIKILKHFKHE 69 +S++G+GA+ V +K TGE+ A+K I L +LR+ REI I +HE Sbjct: 22 RSVIGKGAFSTVHRCVNKRTGEVCAVKVI-----ALKSLRSSEINKIKREIGICSSLQHE 76 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 +I+++ +F + + Y++ E + +++ + ++ ++Q L A++ Sbjct: 77 HIVSMRR-----AFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQH 131 Query: 128 LHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 H N+IHRDLKP NLL+ S N +K+ DFGLA I+++ PT + Sbjct: 132 CHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQG------PT-----YFGFAG 180 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 T Y +PEV + Y A+DVW+CG IL L + P F D HQ L + I Sbjct: 181 TPGYLSPEV-IRRVPYDTAVDVWACGVILYILLVGYPPFWEED--HQKL--YAQIKNCQY 235 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 D +P+ + V +L++ ML +P +R T +E L Sbjct: 236 D--------------------FPSPEWDS----VTTAAKELIKAMLEPNPKRRPTVQELL 271 Query: 305 EHPYL 309 +HP++ Sbjct: 272 QHPWI 276 >3Q5I-A nrPDB Length = 504 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 82/311 (26%), Positives = 131/311 (42%), Gaps = 63/311 (20%) Query: 19 LGEGAYGVV--CSATHKPTGEIVAIKKIEPFDK----------PLFALRTLREIKILKHF 66 LG GAYG V C + + + + + K FDK F EI +LK Sbjct: 44 LGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLKSL 103 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRA 124 H NII +F D FE+ Y++ E + ++I+ + + Q L Sbjct: 104 DHPNIIKLF-----DVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSG 158 Query: 125 VKVLHGSNVIHRDLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 + LH N++HRD+KP N+L+ NS ++K+ DFGL+ + + + Sbjct: 159 ICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYK-----------LRD 207 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 + T +Y APEV+ KY+ DVWSCG I+ L P F G+ Sbjct: 208 RLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGGQ--------------- 250 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 ND I+ +Y + ++ + +L++ ML +D KR TA+ Sbjct: 251 ----NDQDIIKKVEKGKYYFDFNDW---------KNISDEAKELIKLMLTYDYNKRCTAE 297 Query: 302 EALEHPYLQTY 312 EAL +++ Y Sbjct: 298 EALNSRWIKKY 308 >4CZT-A nrPDB Length = 464 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 84/302 (27%), Positives = 131/302 (43%), Gaps = 49/302 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKHEN 70 ++L LGEG + V A + G+ VAIK I E K + REI +K KH N Sbjct: 13 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 72 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 +I +F + + ++Y + E + ++ S L +D + + Q + AV Sbjct: 73 VIRMFEVMASKT-----KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYC 127 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H V HRDLKP NLL+++N LKV DFGL+ + + D T G YV Sbjct: 128 HSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHT--TCGTPNYV----- 180 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 APEV+ D+WSCG IL +L+ G + P D++L Sbjct: 181 -APEVINNKGYDGAKADLWSCGVIL------------------FVLMAGYL--PFEDSNL 219 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 + + P + A+ + L++R+L +PA RIT E +E+ + Sbjct: 220 TSLYKKIFKAEFTCPPWFSASAKK------------LIKRILDPNPATRITFAEVIENEW 267 Query: 309 LQ 310 + Sbjct: 268 FK 269 >3Q53-A nrPDB Length = 306 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 80/293 (27%), Positives = 135/293 (46%), Gaps = 47/293 (16%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +G+GA G V +A TG+ VAI+++ +P L + EI +++ K+ NI+ Sbjct: 29 IGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKEL-IINEILVMRENKNPNIVNYL--- 84 Query: 79 RPDSFENFNEVYIIQE-LMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 DS+ +E++++ E L L V++ + + I + L+A++ LH + VIHRD Sbjct: 85 --DSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRD 142 Query: 138 LKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTS 197 +K N+L+ + +K+ DFG ++ T +QS + V T ++ APEV +T Sbjct: 143 IKSDNILLGMDGSVKLTDFGFC----------AQITPEQSKRSTMVGTPYWMAPEV-VTR 191 Query: 198 AKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAR 257 Y +D+WS G + E+ P + + L LI GTP N + Sbjct: 192 KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI-ATNGTPELQNPEK-------- 242 Query: 258 EYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 L +F D L R L D KR +AKE ++H +L+ Sbjct: 243 -------------LSAIFR-------DFLNRCLEMDVEKRGSAKELIQHQFLK 275 >4D28-A nrPDB Length = 446 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 66/205 (32%), Positives = 99/205 (48%), Gaps = 19/205 (9%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKHEN 70 +++ +GEG + V A + TG+ VAIK + K + REI I+K +H N Sbjct: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 I+ ++ + S ++YI+ E + R++ L +D + + Q + AV Sbjct: 71 IVRLYEVLASKS-----KIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHC 125 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H V HRDLKP NLL+++N +LKV DFGL+ + E E G YV Sbjct: 126 HSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGV----ELLNDTCGTPNYV----- 176 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCIL 213 APEV+ A D+WSCG IL Sbjct: 177 -APEVLSGQGYDGSAADIWSCGVIL 200 >1S9I-A nrPDB Length = 354 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 77/242 (31%), Positives = 121/242 (50%), Gaps = 28/242 (11%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 DF+ S LG G GVV H+P+G I+A K I KP + +RE+++L I Sbjct: 17 DFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 76 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI-STQMLSDDHIQYFIYQTLRAVKVLH 129 + + +F + E+ I E M L +V+ + + ++ + LR + L Sbjct: 77 VGFYG-----AFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLR 131 Query: 130 GSN-VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 + ++HRD+KPSN+L+NS ++K+CDFG++ + +S A++ +V TR Y Sbjct: 132 EKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS------------FVGTRSY 179 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG--II----GTP 242 APE L YS D+WS G L EL + R P D + +L IFG ++ G P Sbjct: 180 MAPE-RLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAK-ELEAIFGRPVVDGEEGEP 237 Query: 243 HS 244 HS Sbjct: 238 HS 239 >4C0T-A nrPDB Length = 974 Score = 97.4 bits (241), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 86/318 (27%), Positives = 146/318 (45%), Gaps = 53/318 (16%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKI 62 K I N++ DF+ LGEG+Y V AT K TG+ A+K ++ + + + ++ + I Sbjct: 259 KTIRRNVT-DFKFGKELGEGSYSTVILATDKITGKQYAVKVLD--KRHIIKEKKVKYVNI 315 Query: 63 LKHFKHE-----NIITI-FNIQRPDSFENFNEVYIIQELMQTDLHRVIST-QMLSDDHIQ 115 KH + +I++ F Q DS +++ +L +I L+++ + Sbjct: 316 EKHALNRLSNRLGVISLYFTFQDKDSL-----YFVLDYASNGELLTLIKRYNTLNEECTR 370 Query: 116 YFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQ 175 +F Q L A+K +H + VIHRDLKP N+L++ +++ DFG AR++ E D SE Sbjct: 371 HFGAQILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLL-EKKNDESEEYPV 429 Query: 176 QSGMTEYVATRWYRAPEVMLTSAKY-SRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLL 234 +V T Y +PE++ KY + DVW+ GCI+ ++ +P F + Sbjct: 430 DVRAKSFVGTAEYVSPELL--ENKYCGKPGDVWAFGCIIYQMIAGKPPFKATN------- 480 Query: 235 IFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFD 293 EY L L+ F P I DL++++LV Sbjct: 481 -----------------------EY---LTFQKITKLQFAFSAGFPTIIRDLIKKILVLQ 514 Query: 294 PAKRITAKEALEHPYLQT 311 P++R T E +H + Q+ Sbjct: 515 PSRRATIPEIQKHYFFQS 532 >2WO6-A nrPDB Length = 382 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 91/345 (26%), Positives = 162/345 (46%), Gaps = 62/345 (17%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF-KHENI 71 +++ SL+G+G++G V A + E VAIK I+ +K F + E+++L+ KH+ Sbjct: 56 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIK--NKKAFLNQAQIEVRLLELMNKHDTE 113 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQTDLH---RVISTQMLSDDHIQYFIYQTLRAVKVL 128 + + + F N + ++ E++ +L+ R + + +S + + F Q A+ L Sbjct: 114 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 173 Query: 129 HGS--NVIHRDLKPSNLLINS--NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 ++IH DLKP N+L+ + +K+ DFG +S GQ+ + +Y+ Sbjct: 174 ATPELSIIHCDLKPENILLCNPKRSAIKIVDFG-----------SSCQLGQR--IYQYIQ 220 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 +R+YR+PEV+L Y A+D+WS GCIL E+ P+F G + Q+ I ++G P + Sbjct: 221 SRFYRSPEVLL-GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 279 Query: 245 DNDLRCIESPRAREYIKSLP-----------------------MYPAAPLEKMFP---RV 278 ++P+AR++ + LP ++ +E P R Sbjct: 280 H---ILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRA 336 Query: 279 NPKG---------IDLLQRMLVFDPAKRITAKEALEHPYLQTYHD 314 G DL+ RML +DP RI AL+H + + D Sbjct: 337 GESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTAD 381 >4D2V-A nrPDB Length = 356 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 84/315 (26%), Positives = 137/315 (43%), Gaps = 51/315 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 ++L +G G + V A H TGE+VAIK ++ R EI+ LK+ +H++I Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHIC 90 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLHG 130 ++++ E N+++++ E +IS LS++ + Q + AV +H Sbjct: 91 QLYHV-----LETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHS 145 Query: 131 SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS-GMTEYVATRWYR 189 HRDLKP NLL + LK+ DFGL ++P G + + Y Sbjct: 146 QGYAHRDLKPENLLFDEYHKLKLIDFGLC----------AKPKGNKDYHLQACCGALAYA 195 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLR 249 APE++ + DVWS G +L +L+ G + P D+ Sbjct: 196 APELIQGKSYLGSEADVWSMGILL------------------YVLMCGFL--PFDDDTAA 235 Query: 250 CIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY- 308 + + R +P + ++P I LLQ+ML DP KRI+ K L HP+ Sbjct: 236 ALVAKIMRGKY-DVPKW-----------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWI 283 Query: 309 LQTYHDPNDEPEGEP 323 +Q Y+ P + P Sbjct: 284 MQDYNYPVEWQSKNP 298 >6FDY-U nrPDB Length = 276 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 90/313 (28%), Positives = 138/313 (44%), Gaps = 58/313 (18%) Query: 13 FQLKSLLGEGAYGVVCSA-THKPTGEIVAIKKIEPFDKPLFALRTL-REIKILKHFKHEN 70 F L LG G Y V A K T E+VAIK + ++ L EI+ILK +H + Sbjct: 13 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPH 72 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQ-MLSDDHIQYFIYQTLRAVKVL 128 I+ + + Q + + +Y+I E DL R I T+ +L + + F+ Q A++ L Sbjct: 73 IVQLKDFQ-----WDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFL 127 Query: 129 HGSNVIHRDLKPSNLLINS--NCDLKVCDFGLARII---DESAADNSEPTGQQSGMTEYV 183 H N+ H DLKP N+L++S LK+ DFG A+ + DE P Sbjct: 128 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL---------- 177 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 Y APE M+ +Y +D+WS G IL E +P F R + Sbjct: 178 ----YMAPE-MVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSE------------- 219 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 +E + LP+ P ++ DLLQR+L DP++RI+ ++ Sbjct: 220 -------LEEKIRSNRVIELPLRPL---------LSRDCRDLLQRLLERDPSRRISFQDF 263 Query: 304 LEHPYLQTYHDPN 316 HP++ H P+ Sbjct: 264 FAHPWVDLEHMPS 276 >3COM-A nrPDB Length = 314 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 83/305 (27%), Positives = 145/305 (47%), Gaps = 57/305 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 F + LGEG+YG V A HK TG+IVAIK++ P + L + ++EI I++ +++ Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV-PVESDLQEI--IKEISIMQQCDSPHVV 87 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 + S+ +++I+ E +D+ R + + L++D I + TL+ ++ L Sbjct: 88 KYYG-----SYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLTEDEIATILQSTLKGLEYL 141 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLA-RIIDESAADNSEPTGQQSGMTEYVATRW 187 H IHRD+K N+L+N+ K+ DFG+A ++ D A N+ + T + Sbjct: 142 HFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT-----------VIGTPF 190 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 + APEV + Y+ D+WS G E+ +P P++D Sbjct: 191 WMAPEV-IQEIGYNCVADIWSLGITAIEMAEGKP--------------------PYAD-- 227 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRV-NPKGIDLLQRMLVFDPAKRITAKEALEH 306 I RA I +P P K P + + D +++ LV P +R TA + L+H Sbjct: 228 ---IHPMRA---IFMIPTNPPPTFRK--PELWSDNFTDFVKQCLVKSPEQRATATQLLQH 279 Query: 307 PYLQT 311 P++++ Sbjct: 280 PFVRS 284 >5J5T-A nrPDB Length = 370 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 94/322 (29%), Positives = 147/322 (45%), Gaps = 43/322 (13%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIK--KIEPFDKPLFALRTLREIKILKHFKHE 69 DF+L +G G YG V A + TGE+ AIK K+EP + FA+ +EI ++K KH Sbjct: 5 DFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED--FAV-VQQEIIMMKDCKHP 61 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQYFIYQTLRAV 125 NI+ F S+ ++++I E D++ V T LS+ I Y +TL+ + Sbjct: 62 NIVAYFG-----SYLRRDKLWICMEFCGGGSLQDIYHV--TGPLSELQIAYVSRETLQGL 114 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 LH +HRD+K +N+L+ N +K+ DFG++ I + A ++ T Sbjct: 115 YYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRK----------AFIGT 164 Query: 186 RWYRAPEVMLTSAK--YSRAMDVWSCGCILAELF-LRRPIFPGRDYRHQLLLIFGIIGTP 242 ++ APEV K Y++ D+W+ G EL L+ P+F R L+ P Sbjct: 165 PYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 224 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 + ++ + S + L K P+ P LLQ V R A E Sbjct: 225 KLKDKMK---------WSNSFHHFVKMALTKN-PKKRPTAEKLLQHPFVTQHLTRSLAIE 274 Query: 303 ALE---HPYLQTYHD-PNDEPE 320 L+ +P TYHD +D+PE Sbjct: 275 LLDKVNNPDHSTYHDFDDDDPE 296 >3IS5-A nrPDB Length = 285 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 87/312 (27%), Positives = 135/312 (43%), Gaps = 66/312 (21%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-EIKILKHFKHENI 71 F K LG GA+G V + +G IK I D+ + + EI++LK H NI Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINK-DRSQVPMEQIEAEIEVLKSLDHPNI 82 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQM----LSDDHIQYFIYQTLRAV 125 I IF + FE+++ +YI+ E + L R++S Q LS+ ++ + Q + A+ Sbjct: 83 IKIFEV-----FEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNAL 137 Query: 126 KVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARII--DESAADNSEPTGQQSGMT 180 H +V+H+DLKP N+L + +K+ DFGLA + DE + T Sbjct: 138 AYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHS-------------T 184 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 T Y APEV + D+WS G ++ FL P G Sbjct: 185 NAAGTALYMAPEVFKRDVTFK--CDIWSAGVVM--YFLLTGCLP-------------FTG 227 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAA--PLEKMFPRVNPKGIDLLQRMLVFDPAKRI 298 T +E + + K P Y PL P+ +DLL++ML DP +R Sbjct: 228 T--------SLEEVQQKATYKE-PNYAVECRPL-------TPQAVDLLKQMLTKDPERRP 271 Query: 299 TAKEALEHPYLQ 310 +A + L H + + Sbjct: 272 SAAQVLHHEWFK 283 >2W4O-A nrPDB Length = 349 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 92/307 (29%), Positives = 139/307 (45%), Gaps = 54/307 (17%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFK 67 +S F+++S LG GA +V K T + A+K ++ DK + +RT EI +L Sbjct: 51 LSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI--VRT--EIGVLLRLS 106 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H NII + I FE E+ ++ EL+ R++ S+ + Q L AV Sbjct: 107 HPNIIKLKEI-----FETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAV 161 Query: 126 KVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 LH + ++HRDLKP NLL + + LK+ DFGL++I++ Q M Sbjct: 162 AYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVE-----------HQVLMKTV 210 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 T Y APE++ A Y +D+WS G I L P D R + I Sbjct: 211 CGTPGYCAPEILRGCA-YGPEVDMWSVGIITYILLC--GFEPFYDERGDQFMFRRI---- 263 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 L C EY P + L N K DL+++++V DP KR+T + Sbjct: 264 -----LNC-------EYYFISPWWDEVSL-------NAK--DLVRKLIVLDPKKRLTTFQ 302 Query: 303 ALEHPYL 309 AL+HP++ Sbjct: 303 ALQHPWV 309 >5KKR-C nrPDB Length = 395 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 73/233 (31%), Positives = 117/233 (50%), Gaps = 30/233 (12%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 DF+ S LG G GVV +HKP+G ++A K I KP + +RE+++L I Sbjct: 69 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 128 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQT-DLHRV------ISTQMLSDDHIQYFIYQTLRA 124 + + +F + E+ I E M L +V I Q+L + + + L Sbjct: 129 VGFYG-----AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILG--KVSIAVIKGLTY 181 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 ++ H ++HRD+KPSN+L+NS ++K+CDFG++ + +S A++ +V Sbjct: 182 LREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS------------FVG 227 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 TR Y +PE L YS D+WS G L E+ + R P D + +L L+FG Sbjct: 228 TRSYMSPE-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAK-ELELMFG 278 >3EQC-A nrPDB Length = 360 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 90/321 (28%), Positives = 150/321 (46%), Gaps = 47/321 (14%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 DF+ S LG G GVV +HKP+G ++A K I KP + +RE+++L I Sbjct: 34 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 93 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQT-DLHRV------ISTQMLSDDHIQYFIYQTLRA 124 + + +F + E+ I E M L +V I Q+L + + + L Sbjct: 94 VGFYG-----AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILG--KVSIAVIKGLTY 146 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 ++ H ++HRD+KPSN+L+NS ++K+CDFG++ + +S A++ +V Sbjct: 147 LREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS------------FVG 192 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG--IIGTP 242 TR Y +PE L YS D+WS G L E+ + R P D + +L L+FG + G Sbjct: 193 TRSYMSPE-RLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAK-ELELMFGCQVEGDA 250 Query: 243 HSDNDLRCIESPRAREY-IKSLPMYPAAPLEKMFPRVN------PKGI------DLLQRM 289 ++ + S P P A E + VN P G+ D + + Sbjct: 251 AETPPRPRTPGRPLNKFGMDSRP--PMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKC 308 Query: 290 LVFDPAKRITAKEALEHPYLQ 310 L+ +PA+R K+ + H +++ Sbjct: 309 LIKNPAERADLKQLMVHAFIK 329 >3ORZ-A nrPDB Length = 316 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 77/294 (26%), Positives = 130/294 (44%), Gaps = 48/294 (16%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP--FDKPLFALRTLREIKILKHFKHE 69 DF+ +LGEG++ V A T AIK +E K RE ++ H Sbjct: 38 DFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHP 97 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 + ++ + D F Y + + ++ S + +++ + + A++ LH Sbjct: 98 FFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGS---FDETCTRFYTAEIVSALEYLH 154 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 G +IHRDLKP N+L+N + +++ DFG A+++ P +Q+ +V T Y Sbjct: 155 GKGIIHRDLKPENILLNEDMHIQITDFGTAKVLS--------PESKQARANSFVGTAQYV 206 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF-PGRDYRHQLLLIFGIIGTPHSDNDL 248 +PE +LT ++ D+W+ GCI+ +L P F G +Y LIF I Sbjct: 207 SPE-LLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY-----LIFQKI--------- 251 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 IK +P EK FP+ DL++++LV D KR+ +E Sbjct: 252 -----------IKLEYDFP----EKFFPKAR----DLVEKLLVLDATKRLGCEE 286 >4AN9-A nrPDB Length = 301 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 87/307 (28%), Positives = 140/307 (45%), Gaps = 61/307 (19%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 DF+ S LG G GVV +HKP+G ++A K I KP + +RE+++L I Sbjct: 10 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 69 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQT-DLHRV------ISTQMLSDDHIQYFIYQTLRA 124 + + +F + E+ I E M L +V I Q+L + + + L Sbjct: 70 VGFYG-----AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGK--VSIAVIKGLTY 122 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLA-RIIDESAADNSEPTGQQSGMTEYV 183 ++ H ++HRD+KPSN+L+NS ++K+CDFG++ ++IDE A E+V Sbjct: 123 LREKH--KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMA-------------NEFV 167 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 TR Y +PE L YS D+WS G L E+ + R Y + IF ++ Sbjct: 168 GTRSYMSPE-RLQGTHYSVQSDIWSMGLSLVEMAVGR-------YPRPPMAIFELL---- 215 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 D E P P P+A F D + + L+ +PA+R K+ Sbjct: 216 ---DYIVNEPP---------PKLPSAVFSLEFQ-------DFVNKCLIKNPAERADLKQL 256 Query: 304 LEHPYLQ 310 + H +++ Sbjct: 257 MVHAFIK 263 >4YZB-A nrPDB Length = 491 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 81/315 (25%), Positives = 141/315 (44%), Gaps = 53/315 (16%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP--FDKPLFALRTLREIKILKHFK 67 S ++ + +LG+G++G V K TG+ A+K I + L+E+++LK Sbjct: 29 SDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLD 88 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H NI+ ++ FE+ Y++ E+ +IS + S+ I Q L + Sbjct: 89 HPNIMKLYEF-----FEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGI 143 Query: 126 KVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 +H + ++HRDLKP NLL+ + + ++++ DFGL+ + + M + Sbjct: 144 TYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKK-----------MKDK 192 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 + T +Y APEV+ Y DVWS G IL L P F G Sbjct: 193 IGTAYYIAPEVL--HGTYDEKCDVWSTGVILYILLSGCPPFNGA---------------- 234 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 N+ ++ ++ LP + +V+ DL+++ML + P RI+A++ Sbjct: 235 ---NEFDILKKVEKGKFTFDLPQW---------KKVSEPAKDLIRKMLAYVPTMRISARD 282 Query: 303 ALEHPYLQTYHDPND 317 ALEH +L+T D Sbjct: 283 ALEHEWLKTTDAATD 297 >2BRG-A nrPDB Length = 297 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 61/208 (29%), Positives = 99/208 (47%), Gaps = 15/208 (7%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 D+ L LGEGAYG V A ++ T E VA+K ++ +EI I K HEN+ Sbjct: 8 DWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENV 67 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 + + +R + + Y+ E R+ + + Q F +Q + V LH Sbjct: 68 VKFYGHRREGNIQ-----YLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 G + HRD+KP NLL++ +LK+ DFGLA + + ++ + + T Y Sbjct: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYN--------NRERLLNKMCGTLPYV 174 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELF 217 APE++ ++ +DVWSCG +L + Sbjct: 175 APELLKRREFHAEPVDVWSCGIVLTAML 202 >5WAX-A nrPDB Length = 310 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 84/304 (27%), Positives = 130/304 (42%), Gaps = 54/304 (17%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 ++L +G G +GV ++ G++VA+K IE +K REI + +H NII Sbjct: 13 YELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEK--IDENVQREIINHRSLRHPNII 70 Query: 73 TIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGS 131 I P E EL + R+ + S+D ++F Q + V H Sbjct: 71 RFKEVILTPTHLAIVMEYASGGELFE----RICNAGRFSEDEARFFFQQLISGVSYCHSM 126 Query: 132 NVIHRDLKPSNLLINSNCD--LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 V HRDLK N L++ + LK+CDFG ++ S+ +S+P V T Y Sbjct: 127 QVCHRDLKLENTLLDGSTAPRLKICDFGYSK----SSVLHSQPKST-------VGTPAYI 175 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG----RDYRHQLLLIFGIIGTPHSD 245 APEV+L + DVWSCG L + + F +++R + I G+ Sbjct: 176 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV------- 228 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 +Y S+P Y ++P+ DL+ R+ V +PA RIT E Sbjct: 229 ------------QY--SIPDY---------VHISPECQDLISRIFVANPATRITIPEIRN 265 Query: 306 HPYL 309 HP+ Sbjct: 266 HPWF 269 >3TAC-A nrPDB Length = 361 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 88/311 (28%), Positives = 140/311 (45%), Gaps = 58/311 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF---DKPLFALRTL-REIKILKHFKH 68 ++L ++G+G + VV ++ TG+ A+K ++ P + L RE I KH Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQ-TDL-----HRVISTQMLSDDHIQYFIYQTL 122 +I+ + D +Y++ E M DL R + + S+ +++ Q L Sbjct: 88 PHIVELLETYSSDGM-----LYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQIL 142 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 A++ H +N+IHRD+KP +L+ S + +K+ FG+A + ES G +G Sbjct: 143 EALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGES--------GLVAGG 194 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 V T + APEV + Y + +DVW CG IL L F G R L GII Sbjct: 195 R--VGTPHFMAPEV-VKREPYGKPVDVWGCGVILFILLSGCLPFYGTKER----LFEGII 247 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 + N PR + ++ DL++RML+ DPA+RIT Sbjct: 248 KGKYKMN-------PR------------------QWSHISESAKDLVRRMLMLDPAERIT 282 Query: 300 AKEALEHPYLQ 310 EAL HP+L+ Sbjct: 283 VYEALNHPWLK 293 >3F3Z-A nrPDB Length = 277 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 86/313 (27%), Positives = 133/313 (42%), Gaps = 62/313 (19%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-----EPFDKPLFALRTLREIKI 62 +I+ + L++ +G G++G V A K T A KKI E D R +EI+I Sbjct: 6 DINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD------RFKQEIEI 59 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQ 120 +K H NII ++ ++FE+ ++Y++ EL RV+ ++ + + Sbjct: 60 MKSLDHPNIIRLY-----ETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKD 114 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 L AV H NV HRDLKP N L + + LK+ DFGLA Sbjct: 115 VLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKM---------- 164 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 M V T +Y +P+V+ Y D WS G ++ L P F +L I Sbjct: 165 -MRTKVGTPYYVSPQVL--EGLYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKI-- 219 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 RE + P EK + V+P+ L++R+L P +R Sbjct: 220 -------------------REGTFTFP-------EKDWLNVSPQAESLIRRLLTKSPKQR 253 Query: 298 ITAKEALEHPYLQ 310 IT+ +ALEH + + Sbjct: 254 ITSLQALEHEWFE 266 >4B6L-A nrPDB Length = 281 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 69/216 (31%), Positives = 101/216 (46%), Gaps = 20/216 (9%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKHENIITIF 75 LLG+G + AT TG A+K I KP + L EI++ + +H +I+ Sbjct: 16 LLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFS 75 Query: 76 NIQRPDSFENFNEVYIIQELM--QTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNV 133 + FE+ + +YI EL ++ H + L + ++Y++ Q L +K LH + Sbjct: 76 H-----HFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI 130 Query: 134 IHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV 193 +HRDLK N I N +LKV DFGLA + EP Q+ T Y APEV Sbjct: 131 LHRDLKLGNFFITENMELKVGDFGLAARL--------EPPEQRKKTI--CGTPNYVAPEV 180 Query: 194 MLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 +L A DVWS GC++ L P F D + Sbjct: 181 LLRQGHGPEA-DVWSLGCVMYTLLCGSPPFETADLK 215 >3DB8-A nrPDB Length = 317 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 86/318 (27%), Positives = 137/318 (43%), Gaps = 57/318 (17%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEP--FDKPLFALRTLREIKILKHFKHENIITIF 75 LG+G + T T E+ A K + KP + EI I K + +++ Sbjct: 49 FLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGFH 108 Query: 76 NIQRPDSFENFNEVYIIQELMQT----DLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGS 131 FE+ + VY++ E+ + +LH+ + +++ +YF+ QT++ V+ LH + Sbjct: 109 GF-----FEDDDFVYVVLEICRRRSLLELHK--RRKAVTEPEARYFMRQTIQGVQYLHNN 161 Query: 132 NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 VIHRDLK NL +N + D+K+ DFGLA I+ + G T Y AP Sbjct: 162 RVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCG----------TPNYIAP 211 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCI 251 EV L +S +D+WS GCIL L + +P F + + I Sbjct: 212 EV-LCKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRI---------------- 254 Query: 252 ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQT 311 + EY S+P + +NP L++RML DP R + E L + + Sbjct: 255 ---KKNEY--SVPRH-----------INPVASALIRRMLHADPTLRPSVAELLTDEFFTS 298 Query: 312 YHDPNDEPEG-EPIPPSF 328 + P P +PP F Sbjct: 299 GYAPMRLPTSCLTVPPRF 316 >3VN9-A nrPDB Length = 340 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 84/305 (27%), Positives = 132/305 (43%), Gaps = 54/305 (17%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 LG GAYGVV H P+G+I+A+K+I R L ++ I + F + Sbjct: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI----SMRTVDCPFTVT 114 Query: 79 RPDSFENFNEVYIIQELMQTDLHR-----VISTQMLSDDHIQYFIYQTLRAVKVLHGS-N 132 + +V+I ELM T L + + Q + +D + ++A++ LH + Sbjct: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 Query: 133 VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPE 192 VIHRD+KPSN+LIN+ +K+CDFG++ + +S A + + Y APE Sbjct: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-----------AGCKPYMAPE 223 Query: 193 VM---LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLR 249 + L YS D+WS G + EL + R FP + GTP + Sbjct: 224 RINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSW-----------GTPFQQLK-Q 269 Query: 250 CIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 +E P P PA F +D + L + +R T E ++HP+ Sbjct: 270 VVEEPS--------PQLPADKFSAEF-------VDFTSQCLKKNSKERPTYPELMQHPFF 314 Query: 310 QTYHD 314 T H+ Sbjct: 315 -TLHE 318 >4NIF-A nrPDB Length = 333 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 82/310 (26%), Positives = 133/310 (42%), Gaps = 59/310 (19%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKIL-KHFKH 68 S + +K +G G+Y HK T A+K I+ + EI+IL ++ +H Sbjct: 7 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRD-----PSEEIEILLRYGQH 61 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 NIIT+ D +++ VY++ ELM+ L +++ + S+ + ++ + V+ Sbjct: 62 PNIITL-----KDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVE 116 Query: 127 VLHGSNVIHRDLKPSNLLI-----NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 LH V+HRDLKPSN+L N C L++CDFG A+ + P Sbjct: 117 YLHSQGVVHRDLKPSNILYVDESGNPEC-LRICDFGFAKQLRAENGLLMTPC-------- 167 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG--RDYRHQLLLIFGII 239 Y A + APEV L Y D+WS G +L + F D ++L G Sbjct: 168 YTAN--FVAPEV-LKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSG 224 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 S + + V+ DL+ +ML DP +R+T Sbjct: 225 KFTLSGGN---------------------------WNTVSETAKDLVSKMLHVDPHQRLT 257 Query: 300 AKEALEHPYL 309 AK+ L+HP++ Sbjct: 258 AKQVLQHPWV 267 >4CFH-A nrPDB Length = 493 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 80/305 (26%), Positives = 125/305 (40%), Gaps = 58/305 (19%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIK-----KIEPFDKPLFALRTLREIKILKHFK 67 + L LG G +G V H+ TG VA+K KI D + REI+ LK F+ Sbjct: 35 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLD---VVGKIRREIQNLKLFR 91 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H +II ++ + S +++++ E + + L + + Q L V Sbjct: 92 HPHIIKLYQVISTPS-----DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGV 146 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 H V+HRDLKP N+L++++ + K+ DFGL+ ++ + + E ++ Sbjct: 147 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 206 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 R Y PEV D+WS G IL L + GT D Sbjct: 207 RLYAGPEV-----------DIWSSGVILYAL---------------------LCGTLPFD 234 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 +D + + I P Y +NP I LL+ ML DP KR T K+ E Sbjct: 235 DDHVPTLFKKICDGIFYTPQY-----------LNPSVISLLKHMLQVDPMKRATIKDIRE 283 Query: 306 HPYLQ 310 H + + Sbjct: 284 HEWFK 288 >3FME-A nrPDB Length = 290 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 85/306 (27%), Positives = 133/306 (43%), Gaps = 56/306 (18%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 LG GAYGVV H P+G+I+A+K+I R L ++ I + F + Sbjct: 15 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI----SMRTVDCPFTVT 70 Query: 79 RPDSFENFNEVYIIQELMQTDLHR-----VISTQMLSDDHIQYFIYQTLRAVKVLHGS-N 132 + +V+I ELM T L + + Q + +D + ++A++ LH + Sbjct: 71 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 130 Query: 133 VIHRDLKPSNLLINSNCDLKVCDFGLAR-IIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 VIHRD+KPSN+LIN+ +K+CDFG++ ++D+ A D + Y AP Sbjct: 131 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDID------------AGCKPYMAP 178 Query: 192 EVM---LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 E + L YS D+WS G + EL + R FP + GTP Sbjct: 179 ERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSW-----------GTPFQQLK- 224 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 + +E P P PA F +D + L + +R T E ++HP+ Sbjct: 225 QVVEEPS--------PQLPADKFSAEF-------VDFTSQCLKKNSKERPTYPELMQHPF 269 Query: 309 LQTYHD 314 T H+ Sbjct: 270 F-TLHE 274 >4RED-A nrPDB Length = 351 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 79/305 (25%), Positives = 125/305 (40%), Gaps = 58/305 (19%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIK-----KIEPFDKPLFALRTLREIKILKHFK 67 + L LG G +G V H+ TG VA+K KI D + REI+ LK F+ Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLD---VVGKIRREIQNLKLFR 72 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H +II ++ + S +++++ E + + L + + Q L V Sbjct: 73 HPHIIKLYQVISTPS-----DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGV 127 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 H V+HRDLKP N+L++++ + K+ DFGL+ ++ + + E ++ Sbjct: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 R Y PEV D+WS G IL L + GT D Sbjct: 188 RLYAGPEV-----------DIWSSGVILYAL---------------------LCGTLPFD 215 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 +D + + I P Y +NP I LL+ ML DP KR + K+ E Sbjct: 216 DDHVPTLFKKICDGIFYTPQY-----------LNPSVISLLKHMLQVDPMKRASIKDIRE 264 Query: 306 HPYLQ 310 H + + Sbjct: 265 HEWFK 269 >1ZXE-A nrPDB Length = 303 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 62/222 (27%), Positives = 113/222 (50%), Gaps = 17/222 (7%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 +SDF+ ++LG+GA+G V A + AIKKI ++ L + L E+ +L H+ Sbjct: 5 ASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTI--LSEVMLLASLNHQ 62 Query: 70 NIITIF-------NIQRP-DSFENFNEVYIIQELMQT-DLHRVISTQMLSDDHIQYF--I 118 ++ + N +P + + + ++I E + L+ +I ++ L+ +Y+ Sbjct: 63 YVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLF 122 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLA----RIIDESAADNSEPTG 174 Q L A+ +H +IHR+LKP N+ I+ + ++K+ DFGLA R +D D+ G Sbjct: 123 RQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPG 182 Query: 175 QQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 +T + T Y A EV+ + Y+ +D++S G I E+ Sbjct: 183 SSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEM 224 >4U41-A nrPDB Length = 332 Score = 91.3 bits (225), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 105/216 (48%), Gaps = 26/216 (12%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH-ENI 71 F+L ++G G YG V H TG++ AIK ++ + ++ EI +LK + H NI Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL--EINMLKKYSHHRNI 83 Query: 72 ITIFNI---QRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQYFIYQTLRA 124 T + + P ++ +++++ E TDL + L +D I Y + LR Sbjct: 84 ATYYGAFIKKSPPGHDD--QLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRG 141 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + LH +VIHRD+K N+L+ N ++K+ DFG++ +D + + ++ Sbjct: 142 LAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRN----------TFIG 191 Query: 185 TRWYRAPEVMLT----SAKYSRAMDVWSCGCILAEL 216 T ++ APEV+ A Y D+WSCG E+ Sbjct: 192 TPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEM 227 >2WQN-A nrPDB Length = 310 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 112/227 (49%), Gaps = 24/227 (10%) Query: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRT--LREIKILK 64 YN ++F+++ +G G + V A G VA+KK++ FD R ++EI +LK Sbjct: 28 YNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLK 87 Query: 65 HFKHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI-----STQMLSDDHIQYFI 118 H N+I + SF NE+ I+ EL DL R+I +++ + + + Sbjct: 88 QLNHPNVIKYYA-----SFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYF 142 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 Q A++ +H V+HRD+KP+N+ I + +K+ D GL R +S+ T S Sbjct: 143 VQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFF------SSKTTAAHS- 195 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG 225 V T +Y +PE + + Y+ D+WS GC+L E+ + F G Sbjct: 196 ---LVGTPYYMSPERIHENG-YNFKSDIWSLGCLLYEMAALQSPFYG 238 >6AO5-A nrPDB Length = 362 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 80/305 (26%), Positives = 143/305 (46%), Gaps = 57/305 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 F + LGEG+YG V A HK +G++VAIK++ P + L + ++EI I++ ++ Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESDLQEI--IKEISIMQQCDSPYVV 68 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 + S+ +++I+ E +D+ R + + L +D I + TL+ ++ L Sbjct: 69 KYYG-----SYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLIEDEIATILKSTLKGLEYL 122 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLA-RIIDESAADNSEPTGQQSGMTEYVATRW 187 H IHR++K N+L+N+ K+ DFG+A ++ D A N+ + T + Sbjct: 123 HFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT-----------VIGTPF 171 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 + APEV + Y+ D+WS G E+ +P P++D Sbjct: 172 WMAPEV-IQEIGYNCVADIWSLGITSIEMAEGKP--------------------PYAD-- 208 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRV-NPKGIDLLQRMLVFDPAKRITAKEALEH 306 I RA I +P P K P + + D +++ LV +P +R TA + L+H Sbjct: 209 ---IHPMRA---IFMIPTNPPPTFRK--PELWSDDFTDFVKKCLVKNPEQRATATQLLQH 260 Query: 307 PYLQT 311 P+++ Sbjct: 261 PFIKN 265 >4J52-A nrPDB Length = 293 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 86/319 (26%), Positives = 136/319 (42%), Gaps = 59/319 (18%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEP---FDKPLFALRTLREIKILKHFKHENIITI 74 LG+G + + T E+ A KI P KP + EI I + H++++ Sbjct: 21 FLGKGGFAKCFEISDADTKEVFA-GKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGF 79 Query: 75 FNIQRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHG 130 FE+ + V+++ EL + +LH+ + L++ +Y++ Q + + LH Sbjct: 80 HGF-----FEDNDFVFVVLELCRRRSLLELHK--RRKALTEPEARYYLRQIVLGCQYLHR 132 Query: 131 SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRA 190 + VIHRDLK NL +N + ++K+ DFGLA ++ G T Y A Sbjct: 133 NRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCG----------TPNYIA 182 Query: 191 PEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRC 250 PEV L+ +S +DVWS GCI+ L + +P F + L I Sbjct: 183 PEV-LSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRI--------------- 226 Query: 251 IESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 + EY S+P + +NP L+Q+ML DP R T E L + Sbjct: 227 ----KKNEY--SIPKH-----------INPVAASLIQKMLQTDPTARPTINELLNDEFFT 269 Query: 311 TYHDPNDEP-EGEPIPPSF 328 + + P P IPP F Sbjct: 270 SGYIPARLPITCLTIPPRF 288 >5JZN-A nrPDB Length = 280 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 79/314 (25%), Positives = 133/314 (42%), Gaps = 61/314 (19%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 I+ +++ +G+G + VV + T A+K I+ E+ IL+ K Sbjct: 16 TITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVK 75 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI-STQMLSDDHIQYFIYQTLRAV 125 H NI+ + + + E+Y++ EL++ DL I ST ++ +Y A+ Sbjct: 76 HPNIVLLI-----EEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAI 130 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCD----LKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 K LH N++HRD+KP NLL+ + D LK+ DFGLA I+D + Sbjct: 131 KYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVD-------------GPLYT 177 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG- 240 T Y APE++ + Y +D+W+ G I L P F G ++L ++G Sbjct: 178 VCGTPTYVAPEIIAETG-YGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQ 236 Query: 241 ----TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAK 296 +P+ DN V+ +L+ ML+ D + Sbjct: 237 VDFPSPYWDN-------------------------------VSDSAKELITMMLLVDVDQ 265 Query: 297 RITAKEALEHPYLQ 310 R +A + LEHP++ Sbjct: 266 RFSAVQVLEHPWVN 279 >4LG4-A nrPDB Length = 299 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 80/304 (26%), Positives = 143/304 (47%), Gaps = 57/304 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 F + LGEG+YG V A HK +G++VAIK++ P + L + ++EI I++ ++ Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESDLQEI--IKEISIMQQCDSPYVV 69 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 + S+ +++I+ E +D+ R + + L +D I + TL+ ++ L Sbjct: 70 KYYG-----SYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLIEDEIATILKSTLKGLEYL 123 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLA-RIIDESAADNSEPTGQQSGMTEYVATRW 187 H IHR++K N+L+N+ K+ DFG+A ++ D A N+ + T + Sbjct: 124 HFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT-----------VIGTPF 172 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 + APEV + Y+ D+WS G E+ +P P++D Sbjct: 173 WMAPEV-IQEIGYNCVADIWSLGITSIEMAEGKP--------------------PYAD-- 209 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRV-NPKGIDLLQRMLVFDPAKRITAKEALEH 306 I RA I +P P K P + + D +++ LV +P +R TA + L+H Sbjct: 210 ---IHPMRA---IFMIPTNPPPTFRK--PELWSDDFTDFVKKCLVKNPEQRATATQLLQH 261 Query: 307 PYLQ 310 P+++ Sbjct: 262 PFIK 265 >4OW8-A nrPDB Length = 283 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 67/229 (29%), Positives = 104/229 (45%), Gaps = 14/229 (6%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK--KIEPFDKPLFALRTLR 58 M R+ +S ++L+ L+ G G V A G VA+K K E P F R Sbjct: 1 MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRA 60 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIS-TQMLSDDHIQY 116 E + H I ++ + Y++ EL+ + L+ V+ T LS H Sbjct: 61 EARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALD 120 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 + QT RA+++ H + ++HRD+KP N+LI +K+ DFG+A+ +D + Q Sbjct: 121 MLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPV-------TQ 173 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG 225 +GM + T Y APE L S A DV+S G + E + F G Sbjct: 174 TGMV--MGTAQYIAPEQAL-GHDASPASDVYSLGVVGYEAVSGKRPFAG 219 >3D2K-A nrPDB Length = 272 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 76/305 (24%), Positives = 127/305 (41%), Gaps = 56/305 (18%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKHE 69 DF + LG+G +G V A + + I+A+K + +K + RE++I H +H Sbjct: 13 DFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHP 72 Query: 70 NIITIFNIQRPDSFENFNEVYIIQEL--MQTDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ ++ F + VY+I E + T + + +I + A+ Sbjct: 73 NILRLYGY-----FHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSY 127 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H VIHRD+KP NLL+ SN +LK+ DFG + P+ ++ T T Sbjct: 128 CHSKRVIHRDIKPENLLLGSNGELKIADFGWS---------VHAPSSRR---TTLCGTLD 175 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y PE M+ + +D+WS G + E + P F Y+ I Sbjct: 176 YLPPE-MIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRI------------ 222 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFDPAKRITAKEALEH 306 + +E FP +G DL+ R+L + ++R+T E LEH Sbjct: 223 ---------------------SRVEFTFPDFVTEGARDLISRLLKHNASQRLTLAEVLEH 261 Query: 307 PYLQT 311 P+++ Sbjct: 262 PWIKA 266 >2OU7-A nrPDB Length = 335 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 87/319 (27%), Positives = 139/319 (43%), Gaps = 59/319 (18%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEP---FDKPLFALRTLREIKILKHFKHENIITI 74 LG+G + + T E+ A KI P KP + EI I + H++++ Sbjct: 48 FLGKGGFAKCFEISDADTKEVFA-GKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGF 106 Query: 75 FNIQRPDSFENFNEVYIIQELMQT----DLHRVISTQMLSDDHIQYFIYQTLRAVKVLHG 130 FE+ + V+++ EL + +LH+ + L++ +Y++ Q + + LH Sbjct: 107 HGF-----FEDNDFVFVVLELCRRRSLLELHK--RRKALTEPEARYYLRQIVLGCQYLHR 159 Query: 131 SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRA 190 + VIHRDLK NL +N + ++K+ DFGLA + E G++ + T Y A Sbjct: 160 NRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV--------EYDGERKKV--LCGTPNYIA 209 Query: 191 PEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRC 250 PEV L+ +S +DVWS GCI+ L + +P F + L I Sbjct: 210 PEV-LSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRI--------------- 253 Query: 251 IESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 + EY S+P + +NP L+Q+ML DP R T E L + Sbjct: 254 ----KKNEY--SIPKH-----------INPVAASLIQKMLQTDPTARPTINELLNDEFFT 296 Query: 311 TYHDPNDEP-EGEPIPPSF 328 + + P P IPP F Sbjct: 297 SGYIPARLPITCLTIPPRF 315 >4YNZ-A nrPDB Length = 342 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 81/319 (25%), Positives = 141/319 (44%), Gaps = 59/319 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKHEN 70 ++L+ LG+G G+V H T + VAIK + E + + ++ REI ILK +H + Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVL-MKVEREIAILKLIEHPH 70 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 ++ + D +EN +Y++ E + ++ L+ + F Q + A+ Sbjct: 71 VLKLH-----DVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFC 125 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARI-IDESAADNSEPTGQQSGMTEYVATRW 187 H ++ HRDLKP NLL++ ++++ DFG+A + + +S + S + Sbjct: 126 HSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETS------------CGSPH 173 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y PEV+ R DVWSCG IL L + P D++ Sbjct: 174 YACPEVIRGEKYDGRKADVWSCGVILFALL--------------------VGALPFDDDN 213 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 LR + + + + +P + + P LL+ M+ D A+R+T + +H Sbjct: 214 LRQLLE-KVKRGVFHMPHF-----------IPPDCQSLLRGMIEVDAARRLTLEHIQKHI 261 Query: 308 YLQTYHDPNDEPEGE-PIP 325 + Y +EPE E PIP Sbjct: 262 W---YIGGKNEPEPEQPIP 277 >4REW-A nrPDB Length = 540 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 78/305 (25%), Positives = 125/305 (40%), Gaps = 58/305 (19%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIK-----KIEPFDKPLFALRTLREIKILKHFK 67 + L LG G +G V H+ TG VA+K KI D + REI+ LK F+ Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLD---VVGKIRREIQNLKLFR 64 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H +II ++ + ++++++ E + + L + + Q L V Sbjct: 65 HPHIIKLYQV-----ISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGV 119 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 H V+HRDLKP N+L++++ + K+ DFGL+ ++ + + E ++ Sbjct: 120 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 179 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 R Y PEV D+WS G IL L + GT D Sbjct: 180 RLYAGPEV-----------DIWSSGVILYAL---------------------LCGTLPFD 207 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 +D + + I P Y +NP I LL+ ML DP KR + K+ E Sbjct: 208 DDHVPTLFKKICDGIFYTPQY-----------LNPSVISLLKHMLQVDPMKRASIKDIRE 256 Query: 306 HPYLQ 310 H + + Sbjct: 257 HEWFK 261 >4UZD-A nrPDB Length = 287 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 76/303 (25%), Positives = 124/303 (40%), Gaps = 56/303 (18%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKHE 69 DF++ LG+G +G V A K + I+A+K + +K + RE++I H +H Sbjct: 9 DFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHP 68 Query: 70 NIITIFNIQRPDSFENFNEVYIIQEL--MQTDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ ++ F + VY+I E + T + + +I + A+ Sbjct: 69 NILRLYGY-----FHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSY 123 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H VIHRD+KP NLL+ S +LK+ DFG + S T T Sbjct: 124 CHSKRVIHRDIKPENLLLGSAGELKIADFGWS------------VHAPSSRRTTLCGTLD 171 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y PE M+ + +D+WS G + E + +P F Y+ I Sbjct: 172 YLPPE-MIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRI------------ 218 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFDPAKRITAKEALEH 306 + +E FP +G DL+ R+L +P++R +E LEH Sbjct: 219 ---------------------SRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEH 257 Query: 307 PYL 309 P++ Sbjct: 258 PWI 260 >4X3F-A nrPDB Length = 337 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 67/229 (29%), Positives = 104/229 (45%), Gaps = 14/229 (6%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK--KIEPFDKPLFALRTLR 58 M R+ +S ++L+ L+ G G V A G VA+K K E P F R Sbjct: 2 MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRA 61 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIS-TQMLSDDHIQY 116 E + H I ++ + Y++ EL+ + L+ V+ T LS H Sbjct: 62 EARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALD 121 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 + QT RA+++ H + ++HRD+KP N+LI +K+ DFG+A+ +D + Q Sbjct: 122 MLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPV-------TQ 174 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG 225 +GM + T Y APE L S A DV+S G + E + F G Sbjct: 175 TGMV--MGTAQYIAPEQAL-GHDASPASDVYSLGVVGYEAVSGKRPFAG 220 >6CQF-A nrPDB Length = 297 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 70/221 (31%), Positives = 110/221 (49%), Gaps = 31/221 (14%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIK--KIEPFDKPLFALRTL-REIKILKHFKHE 69 + L LG G YG V A K +G++VA+K K+EP D + TL +EI ILK +H Sbjct: 18 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDD----VSTLQKEILILKTCRHA 73 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQT----DLHRVISTQMLSDDHIQYFIYQTLRAV 125 NI+ S+ +++I E D+++V T LS+ I Y + L+ + Sbjct: 74 NIVAYHG-----SYLWLQKLWICMEFCGAGSLQDIYQV--TGSLSELQISYVCREVLQGL 126 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 LH IHRD+K +N+LIN ++++ DFG++ I + A ++ T Sbjct: 127 AYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARR----------LAFIGT 176 Query: 186 RWYRAPEVMLTSAK--YSRAMDVWSCGCILAELF-LRRPIF 223 ++ APEV + K Y+ D+WS G EL L+ P+F Sbjct: 177 PYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLF 217 >6CMJ-A nrPDB Length = 321 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 85/327 (25%), Positives = 146/327 (44%), Gaps = 65/327 (19%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD---------KPLFALRTL-REIKI 62 + LK +G+G+YGVV A ++ A+K + +P + + +EI I Sbjct: 36 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAI 95 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDHIQYFIYQT 121 LK H N++ + + N + +Y++ EL+ Q + V + + LS+D +++ Sbjct: 96 LKKLDHPNVVKLVEVLDD---PNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDL 152 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 ++ ++ LH +IHRD+KPSNLL+ + +K+ DFG++ +E G + ++ Sbjct: 153 IKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVS----------NEFKGSDALLSN 202 Query: 182 YVATRWYRAPEVMLTSAKY--SRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 V T + APE + + K +A+DVW+ G L +FG Sbjct: 203 TVGTPAFMAPESLSETRKIFSGKALDVWAMGVTL------------------YCFVFG-- 242 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPM-YPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI 298 P D + C+ S IKS + +P P + DL+ RML +P RI Sbjct: 243 QCPFMDERIMCLHSK-----IKSQALEFPDQ------PDIAEDLKDLITRMLDKNPESRI 291 Query: 299 TAKEALEHPYLQTYHDPNDEPEGEPIP 325 E HP++ T H EP+P Sbjct: 292 VVPEIKLHPWV-TRHG------AEPLP 311 >5YKS-A nrPDB Length = 377 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 83/307 (27%), Positives = 132/307 (42%), Gaps = 53/307 (17%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTL-REIKILKHFK 67 I+ + L LG G + VV A H TGE VA+K I+ A L +E++ +K + Sbjct: 33 IAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQ 92 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI--STQMLSDDHIQYFIYQTLRA 124 H NI+ ++ + + ++Y+I EL D+ I + L++D + + Q + A Sbjct: 93 HPNIVRLYEV-----IDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHA 147 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDL-KVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 + H +V+HRDLKP N++ L K+ DFG + N G++ +T Sbjct: 148 ISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFS---------NKFQPGKK--LTTSC 196 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 + Y APE++L + A+D+WS G IL L +P F + L +I T Sbjct: 197 GSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVP 256 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 S C DL+ RML DP +R + +E Sbjct: 257 SHVSKEC--------------------------------KDLITRMLQRDPKRRASLEEI 284 Query: 304 LEHPYLQ 310 HP+LQ Sbjct: 285 ENHPWLQ 291 >5XZW-A nrPDB Length = 471 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 82/319 (25%), Positives = 133/319 (41%), Gaps = 61/319 (19%) Query: 8 NISSDFQL-KSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 I DF + ++G+GA+ V A + TG+ A+K I RE+++L+ Sbjct: 192 GIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKL 251 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQ-MLSDDHIQYFIYQTLRA 124 H I+ + +E+ Y++ E + DL ++ + +D + Q L A Sbjct: 252 NHPRIVRLKGF-----YEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTA 306 Query: 125 VKVLHGSNVIHRDLKPSNLLINSN--CDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 +K +H + HRDLKP N+LI + +K+ DFGLA++ G S M + Sbjct: 307 IKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKV-----------QGNGSFMKTF 355 Query: 183 VATRWYRAPEVML---TSA---------KYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 T Y APEV+ TS +YS +D+WS GC++ + F G + Sbjct: 356 CGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG-STQD 414 Query: 231 QLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRML 290 QL G Y PL+ R++ + D + +L Sbjct: 415 QLYKQIG-------------------------RGSYHEGPLKDF--RISEEARDFIDSLL 447 Query: 291 VFDPAKRITAKEALEHPYL 309 DP R TA +AL HP++ Sbjct: 448 QVDPNNRSTAAKALNHPWI 466 >6B2Q-A nrPDB Length = 317 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 67/229 (29%), Positives = 104/229 (45%), Gaps = 14/229 (6%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK--KIEPFDKPLFALRTLR 58 M R+ +S ++L+ L+ G G V A G VA+K K E P F R Sbjct: 22 MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRA 81 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIS-TQMLSDDHIQY 116 E + H I ++ + Y++ EL+ + L+ V+ T LS H Sbjct: 82 EARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALD 141 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 + QT RA+++ H + ++HRD+KP N+LI +K+ DFG+A+ +D + Q Sbjct: 142 MLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPV-------TQ 194 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG 225 +GM + T Y APE L S A DV+S G + E + F G Sbjct: 195 TGMV--MGTAQYIAPEQAL-GHDASPASDVYSLGVVGYEAVSGKRPFAG 240 >2XNP-A nrPDB Length = 279 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 69/237 (29%), Positives = 114/237 (48%), Gaps = 35/237 (14%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTL-RE 59 MP R + D+++ +G G+YG K G+I+ K+++ + L E Sbjct: 1 MPSR-----AEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSE 55 Query: 60 IKILKHFKHENIITIFN--IQRPDSFENFNEVYIIQELMQT-DLHRVIST-----QMLSD 111 + +L+ KH NI+ ++ I R ++ +YI+ E + DL VI+ Q L + Sbjct: 56 VNLLRELKHPNIVRYYDRIIDRTNT-----TLYIVMEYCEGGDLASVITKGTKERQYLDE 110 Query: 112 DHIQYFIYQTLRAVKVLH-----GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESA 166 + + + Q A+K H G V+HRDLKP+N+ ++ ++K+ DFGLARI++ Sbjct: 111 EFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDT 170 Query: 167 ADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 S +V T +Y +PE M Y+ D+WS GC+L EL P F Sbjct: 171 ----------SFAKTFVGTPYYMSPEQM-NRMSYNEKSDIWSLGCLLYELCALMPPF 216 >4CFF-A nrPDB Length = 571 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 82/304 (26%), Positives = 122/304 (40%), Gaps = 56/304 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIK-----KIEPFDKPLFALRTLREIKILKHFK 67 + L LG G +G V H+ TG VA+K KI D + REI+ LK F+ Sbjct: 35 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD---VVGKIKREIQNLKLFR 91 Query: 68 HENIITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 H +II ++ I P F E EL + + + + Q L AV Sbjct: 92 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDY----ICKHGRVEEMEARRLFQQILSAVD 147 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H V+HRDLKP N+L++++ + K+ DFGL+ ++ + + E ++ R Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 207 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y PEV D+WSCG IL L + GT D+ Sbjct: 208 LYAGPEV-----------DIWSCGVILYAL---------------------LCGTLPFDD 235 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 + + R + +P Y +N LL ML DP KR T K+ EH Sbjct: 236 EHVPTLFKKIRGGVFYIPEY-----------LNRSVATLLMHMLQVDPLKRATIKDIREH 284 Query: 307 PYLQ 310 + + Sbjct: 285 EWFK 288 >5HVK-A nrPDB Length = 315 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 106/217 (48%), Gaps = 16/217 (7%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRT-LREIKILKHFKHE 69 SD +LG+G +G TH+ TGE++ +K++ FD+ RT L+E+K+++ +H Sbjct: 14 SDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEE--TQRTFLKEVKVMRCLEHP 71 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 N++ + D NF YI ++ + + + +Q + F + LH Sbjct: 72 NVLKFIGVLYKDKRLNFITEYIKGGTLRGII-KSMDSQYPWSQRVS-FAKDIASGMAYLH 129 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS-------GMTEY 182 N+IHR+L N L+ N ++ V DFGLAR++ + ++P G +S Sbjct: 130 SMNIIHRNLNSHNCLVRENKNVVVADFGLARLM---VDEKTQPEGLRSLKKPDRKKRYTV 186 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLR 219 V ++ APE M+ Y +DV+S G +L E+ R Sbjct: 187 VGNPYWMAPE-MINGRSYDEKVDVFSFGIVLCEIIGR 222 >5EZV-A nrPDB Length = 560 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 82/304 (26%), Positives = 122/304 (40%), Gaps = 56/304 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIK-----KIEPFDKPLFALRTLREIKILKHFK 67 + L LG G +G V H+ TG VA+K KI D + REI+ LK F+ Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD---VVGKIKREIQNLKLFR 86 Query: 68 HENIITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 H +II ++ I P F E EL + + + + Q L AV Sbjct: 87 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDY----ICKHGRVEEMEARRLFQQILSAVD 142 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H V+HRDLKP N+L++++ + K+ DFGL+ ++ + + E ++ R Sbjct: 143 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 202 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y PEV D+WSCG IL L + GT D+ Sbjct: 203 LYAGPEV-----------DIWSCGVILYAL---------------------LCGTLPFDD 230 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 + + R + +P Y +N LL ML DP KR T K+ EH Sbjct: 231 EHVPTLFKKIRGGVFYIPEY-----------LNRSVATLLMHMLQVDPLKRATIKDIREH 279 Query: 307 PYLQ 310 + + Sbjct: 280 EWFK 283 >2YZA-A nrPDB Length = 276 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 82/304 (26%), Positives = 121/304 (39%), Gaps = 56/304 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIK-----KIEPFDKPLFALRTLREIKILKHFK 67 + L LG G +G V H+ TG VA+K KI D + REI+ LK F+ Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD---VVGKIKREIQNLKLFR 69 Query: 68 HENIITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 H +II ++ I P F E EL + + + + Q L AV Sbjct: 70 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDY----ICKHGRVEEMEARRLFQQILSAVD 125 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H V+HRDLKP N+L++++ + K+ DFGL+ ++ + E ++ R Sbjct: 126 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGR 185 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y PEV D+WSCG IL L + GT D+ Sbjct: 186 LYAGPEV-----------DIWSCGVILYAL---------------------LCGTLPFDD 213 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 + + R + +P Y +N LL ML DP KR T K+ EH Sbjct: 214 EHVPTLFKKIRGGVFYIPEY-----------LNRSVATLLMHMLQVDPLKRATIKDIREH 262 Query: 307 PYLQ 310 + + Sbjct: 263 EWFK 266 >4JG6-A nrPDB Length = 355 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 79/307 (25%), Positives = 130/307 (42%), Gaps = 53/307 (17%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKIL-KHFKH 68 + +++K +G G+Y V HK T A+K I+ + EI+IL ++ +H Sbjct: 34 TDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRD-----PTEEIEILLRYGQH 88 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 NIIT+ D +++ VY++ ELM+ L +++ + S+ ++ + V+ Sbjct: 89 PNIITL-----KDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVE 143 Query: 127 VLHGSNVIHRDLKPSNLLINSNC----DLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 LH V+HRDLKPSN+L +++CDFG A+ + P Y Sbjct: 144 YLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPC--------Y 195 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 A + APEV L Y A D+WS G +L + TP Sbjct: 196 TAN--FVAPEV-LERQGYDAACDIWSLGVLLYTMLTGY--------------------TP 232 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 ++ E AR + + V+ DL+ +ML DP +R+TA Sbjct: 233 FANGPDDTPEEILARIGSGKFSLSGG-----YWNSVSDTAKDLVSKMLHVDPHQRLTAAL 287 Query: 303 ALEHPYL 309 L HP++ Sbjct: 288 VLRHPWI 294 >5D7A-A nrPDB Length = 308 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 103/216 (47%), Gaps = 26/216 (12%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH-ENI 71 F+L L+G G YG V H TG++ AIK ++ ++ +EI +LK + H NI Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK--QEINMLKKYSHHRNI 76 Query: 72 ITIFNI---QRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQYFIYQTLRA 124 T + + P ++ +++++ E TDL + L ++ I Y + LR Sbjct: 77 ATYYGAFIKKNPPGMDD--QLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 134 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + LH VIHRD+K N+L+ N ++K+ DFG++ +D + + ++ Sbjct: 135 LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRN----------TFIG 184 Query: 185 TRWYRAPEVMLT----SAKYSRAMDVWSCGCILAEL 216 T ++ APEV+ A Y D+WS G E+ Sbjct: 185 TPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEM 220 >5ES1-A nrPDB Length = 328 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 79/319 (24%), Positives = 132/319 (41%), Gaps = 57/319 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHE 69 +++L +G+G + V A H TG VAIK I+ P + RE++I+K H Sbjct: 15 GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHP 74 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ +F + E +Y++ E ++S + + + Q + AV Sbjct: 75 NIVKLFEV-----IETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHY 129 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H N++HRDLK NLL+++ ++K+ DFG + N G S + + + Sbjct: 130 CHQKNIVHRDLKAENLLLDAEANIKIADFGFS---------NEFTLG--SKLDTFCGSPP 178 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APE+ +D+WS G IL L F G H+ + Sbjct: 179 YAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDG-----------------HNLKE 221 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 LR R +P Y + E +L+R LV +PAKR T ++ ++ Sbjct: 222 LR----ERVLRGKYRVPFYMSTDCE-----------SILRRFLVLNPAKRCTLEQIMKDK 266 Query: 308 YLQTYHDPNDEPEGEPIPP 326 ++ + EGE + P Sbjct: 267 WINIGY------EGEELKP 279 >4PDS-A nrPDB Length = 347 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 80/320 (25%), Positives = 133/320 (41%), Gaps = 61/320 (19%) Query: 8 NISSDFQL-KSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 I DF + ++G+GA+ V A + TG+ ++K I RE+++L+ Sbjct: 27 GIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKL 86 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQ-MLSDDHIQYFIYQTLRA 124 H I+ + +E+ Y++ E + DL ++ + +D + Q L A Sbjct: 87 NHPRIVRLKGF-----YEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTA 141 Query: 125 VKVLHGSNVIHRDLKPSNLLINSN--CDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 +K +H + HRDLKP N+LI + +K+ FGLA++ G S M + Sbjct: 142 IKYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKV-----------QGNGSFMKTF 190 Query: 183 VATRWYRAPEVML---TSA---------KYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 T Y APEV+ TS +YS +D+WS GC++ + F G Sbjct: 191 CGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG----- 245 Query: 231 QLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRML 290 S D + R Y PL+ R++ + D + +L Sbjct: 246 -------------STQDQLYKQIGRGS--------YHEGPLKDF--RISEEARDFIDSLL 282 Query: 291 VFDPAKRITAKEALEHPYLQ 310 DP R TA +AL HP+++ Sbjct: 283 QVDPNNRSTAAKALNHPWIK 302 >5KZ7-A nrPDB Length = 346 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 76/319 (23%), Positives = 142/319 (44%), Gaps = 52/319 (16%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTL-REIKILKHFKHE 69 +++L +G+G + V A H TG+ VA+K I+ +L+ L RE++I+K H Sbjct: 33 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 92 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ +F + E +Y++ E +++ + + + Q + AV+ Sbjct: 93 NIVKLFEV-----IETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 147 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H ++HRDLK NLL++++ ++K+ DFG + +E N T + + Sbjct: 148 CHQKFIVHRDLKAENLLLDADMNIKIADFGFS---NEFTFGNKLDT--------FCGSPP 196 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APE+ +DVWS G IL L F G++ + + Sbjct: 197 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLK-----------------E 239 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 LR R +P Y + E +LL++ L+ +P+KR T ++ ++ Sbjct: 240 LR----ERVLRGKYRIPFYMSTDCE-----------NLLKKFLILNPSKRGTLEQIMKDR 284 Query: 308 YLQTYHDPND-EPEGEPIP 325 ++ H+ ++ +P EP+P Sbjct: 285 WMNVGHEDDELKPYVEPLP 303 >2UV2-A nrPDB Length = 325 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 80/299 (26%), Positives = 129/299 (43%), Gaps = 54/299 (18%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 LG+GA+G V A +K T + A K I+ + + EI IL H NI+ + Sbjct: 45 LGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELE-DYMVEIDILASCDHPNIVKLL--- 100 Query: 79 RPDSFENFNEVYIIQELMQTDLHRVISTQM---LSDDHIQYFIYQTLRAVKVLHGSNVIH 135 D+F N ++I+ E + ++ L++ IQ QTL A+ LH + +IH Sbjct: 101 --DAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIH 158 Query: 136 RDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVML 195 RDLK N+L + D+K+ DFG+ +A N+ ++ ++ T ++ APEV++ Sbjct: 159 RDLKAGNILFTLDGDIKLADFGV-------SAKNTRTIQRRDS---FIGTPYWMAPEVVM 208 Query: 196 TSAK----YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD-NDLRC 250 Y DVWS G L E+ P PH + N +R Sbjct: 209 CETSKDRPYDYKADVWSLGITLIEMAEIEP--------------------PHHELNPMRV 248 Query: 251 IESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 + + KS P A P R + D L++ L + R T + L+HP++ Sbjct: 249 L-----LKIAKSEPPTLAQP-----SRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 297 >2QNJ-A nrPDB Length = 328 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 77/318 (24%), Positives = 135/318 (42%), Gaps = 56/318 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHE 69 +++L +G+G + V A H TG VAIK I+ P + RE++I+K H Sbjct: 12 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 71 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ +F + E +Y+I E +++ + + + Q + AV+ Sbjct: 72 NIVKLFEV-----IETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQY 126 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H ++HRDLK NLL++++ ++K+ DFG + N G + + + + Sbjct: 127 CHQKRIVHRDLKAENLLLDADMNIKIADFGFS---------NEFTVGGK--LDTFCGSPP 175 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APE+ +DVWS G IL L F G++ + + Sbjct: 176 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLK-----------------E 218 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 LR R +P Y + E +LL+R LV +P KR T ++ ++ Sbjct: 219 LR----ERVLRGKYRIPFYMSTDCE-----------NLLKRFLVLNPIKRGTLEQIMKDR 263 Query: 308 YLQTYHDPND-----EPE 320 ++ H+ ++ EPE Sbjct: 264 WINAGHEEDELKPFVEPE 281 >3KN6-A nrPDB Length = 325 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 83/336 (24%), Positives = 134/336 (39%), Gaps = 60/336 (17%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HENIITIFNI 77 LGEG++ + HK + + A+K I T +EI LK + H NI+ + + Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISK----RMEANTQKEITALKLCEGHPNIVKLHEV 74 Query: 78 QRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIH 135 F + +++ EL+ R+ + S+ Y + + + AV +H V+H Sbjct: 75 -----FHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVH 129 Query: 136 RDLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPE 192 RDLKP NLL N N ++K+ DFG AR+ +P Q T T Y APE Sbjct: 130 RDLKPENLLFTDENDNLEIKIIDFGFARL---------KPPDNQPLKTP-CFTLHYAAPE 179 Query: 193 VMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIE 252 +L Y + D+WS G IL + + F D R + Sbjct: 180 -LLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHD---------------------RSLT 217 Query: 253 SPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTY 312 A E +K + + + + V+ + DL+Q +L DP KR+ + +LQ Sbjct: 218 CTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDG 277 Query: 313 HDPNDEPEGEP-------------IPPSFFEFDHYK 335 + P P + +F F+ YK Sbjct: 278 SQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYK 313 >3UTO-A nrPDB Length = 573 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 81/323 (25%), Positives = 143/323 (44%), Gaps = 56/323 (17%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHENI 71 + + LG GA+GVV T + TG A K + P + +R +EI+ + +H + Sbjct: 159 YDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR--KEIQTMSVLRHPTL 216 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQ--MLSDDHIQYFIYQTLRAVKVL 128 + + D+FE+ NE+ +I E M +L ++ + +S+D ++ Q + + + Sbjct: 217 VNLH-----DAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHM 271 Query: 129 HGSNVIHRDLKPSNLLINS--NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H +N +H DLKP N++ + + +LK+ DFGL +D + +G E+ Sbjct: 272 HENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQS-----VKVTTGTAEFA--- 323 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 APEV D+WS G + + LL G + D Sbjct: 324 ---APEVA-EGKPVGYYTDMWSVGVL----------------SYILLSGLSPFGGENDDE 363 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 LR ++S M +A F ++ G D ++++L+ DP R+T +ALEH Sbjct: 364 TLRNVKSC-------DWNMDDSA-----FSGISEDGKDFIRKLLLADPNTRMTIHQALEH 411 Query: 307 PYLQTYHDPNDEPEGEPIPPSFF 329 P+L + P + + IP S + Sbjct: 412 PWLTPGNAPGRDSQ---IPSSRY 431 >1KOA-A nrPDB Length = 491 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 81/325 (24%), Positives = 145/325 (44%), Gaps = 60/325 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHENI 71 + + LG GA+GVV T + TG A K + P + +R +EI+ + +H + Sbjct: 53 YDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR--KEIQTMSVLRHPTL 110 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQ--MLSDDHIQYFIYQTLRAVKVL 128 + + D+FE+ NE+ +I E M +L ++ + +S+D ++ Q + + + Sbjct: 111 VNLH-----DAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHM 165 Query: 129 HGSNVIHRDLKPSNLLINS--NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H +N +H DLKP N++ + + +LK+ DFGL +D + +G E+ Sbjct: 166 HENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQS-----VKVTTGTAEFA--- 217 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGI--IGTPHS 244 APEV D+WS G + +L+ G+ G + Sbjct: 218 ---APEVA-EGKPVGYYTDMWSVGVL------------------SYILLSGLSPFGGEND 255 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 D LR ++S M +A F ++ G D ++++L+ DP R+T +AL Sbjct: 256 DETLRNVKSC-------DWNMDDSA-----FSGISEDGKDFIRKLLLADPNTRMTIHQAL 303 Query: 305 EHPYLQTYHDPNDEPEGEPIPPSFF 329 EHP+L + P + + IP S + Sbjct: 304 EHPWLTPGNAPGRDSQ---IPSSRY 325 >4M7I-A nrPDB Length = 299 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 64/223 (28%), Positives = 105/223 (47%), Gaps = 19/223 (8%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +DF+ LG G +GVV A +K AIK+I ++ L + +RE+K L +H Sbjct: 5 TDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 64 Query: 71 IITIFNIQ---------RPDSFENFNEVYIIQELMQTD-----LHRVISTQMLSDDHIQY 116 I+ FN +P S + + +YI +L + + ++ + + + Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVY--LYIQMQLCRKENLKDWMNGRCTIEERERSVCLH 122 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS--EPTG 174 Q AV+ LH ++HRDLKPSN+ + +KV DFGL +D+ + + P Sbjct: 123 IFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 182 Query: 175 QQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 + T V T+ Y +PE + YS +D++S G IL EL Sbjct: 183 AYARHTGQVGTKLYMSPE-QIHGNSYSHKVDIFSLGLILFELL 224 >6E2O-A nrPDB Length = 295 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 100/216 (46%), Gaps = 29/216 (13%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +LG+G YG+V + +AIK+I P ++ EI + KH KH+NI+ Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEI-PERDSRYSQPLHEEIALHKHLKHKNIVQYLG- 86 Query: 78 QRPDSFENFNEVYIIQELMQTDLHRVISTQMLS--------DDHIQYFIYQTLRAVKVLH 129 +F+E I+ M+ +S + S + I ++ Q L +K LH Sbjct: 87 -------SFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLH 139 Query: 130 GSNVIHRDLKPSNLLINSNCD-LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 + ++HRD+K N+LIN+ LK+ DFG ++ + G + T Y Sbjct: 140 DNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRL----------AGINPCTETFTGTLQY 189 Query: 189 RAPEVMLTSAK-YSRAMDVWSCGCILAELFLRRPIF 223 APE++ + Y +A D+WS GC + E+ +P F Sbjct: 190 MAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPF 225 >2WTK-C nrPDB Length = 305 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 85/342 (24%), Positives = 144/342 (42%), Gaps = 54/342 (15%) Query: 13 FQLKSLLGEGAYGVVCSATHKPT---GEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 + + LLGEG+YG V T + +KK + P +EI++L+ +H+ Sbjct: 7 YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHK 66 Query: 70 NIITIFNIQRPDSFENFNEVYIIQEL----MQTDLHRVISTQMLSDDHIQYFIYQTLRAV 125 N+I + ++ E ++Y++ E MQ L V + YF Q + + Sbjct: 67 NVIQLVDVLYN---EEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFC-QLIDGL 122 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 + LH ++H+D+KP NLL+ + LK+ G+A + AAD++ T Q S Sbjct: 123 EYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPA------ 176 Query: 186 RWYRAPEVMLTSAKYSR-AMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 ++ PE+ +S +D+WS G L + F G Sbjct: 177 --FQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEG------------------- 215 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 DN + E+ Y ++P PL DLL+ ML ++PAKR + ++ Sbjct: 216 DNIYKLFENIGKGSY--AIPGDCGPPLS-----------DLLKGMLEYEPAKRFSIRQIR 262 Query: 305 EHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKL 346 +H + + H P + P PIPPS D ++ L+ L Sbjct: 263 QHSWFRKKHPPAEAP--VPIPPSPDTKDRWRSMTVVPYLEDL 302 >3UC3-A nrPDB Length = 361 Score = 84.3 bits (207), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 81/298 (27%), Positives = 118/298 (39%), Gaps = 54/298 (18%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFN-I 77 +G G +GV K T E+VA+K IE REI + +H NI+ I Sbjct: 28 IGSGNFGVARLMRDKLTKELVAVKYIE--RGAAIDENVQREIINHRSLRHPNIVRFKEVI 85 Query: 78 QRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 P E EL + R+ + S+D ++F Q L V H + HRD Sbjct: 86 LTPTHLAIIMEYASGGELYE----RICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 Query: 138 LKPSNLLINSNCD--LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVML 195 LK N L++ + LK+CDFG ++ S+ +S+P V T Y APEV+L Sbjct: 142 LKLENTLLDGSPAPRLKICDFGYSK----SSVLHSQPKST-------VGTPAYIAPEVLL 190 Query: 196 TSAKYSRAMDVWSCGCILAELFLRRPIFPG----RDYRHQLLLIFGIIGTPHSDNDLRCI 251 + DVWSCG L + + F RDYR + I + + D Sbjct: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDD------ 244 Query: 252 ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 R++P+ L+ R+ V DPA RI+ E H + Sbjct: 245 ------------------------IRISPECCHLISRIFVADPATRISIPEIKTHSWF 278 >5YV8-A nrPDB Length = 298 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 68/259 (26%), Positives = 118/259 (45%), Gaps = 48/259 (18%) Query: 55 RTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDH 113 + +EI ILK H N++ + + N + +Y++ EL+ Q + V + + LS+D Sbjct: 82 QVYQEIAILKKLDHPNVVKLVEVLDD---PNEDHLYMVFELVNQGPVMEVPTLKPLSEDQ 138 Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPT 173 +++ ++ ++ LH +IHRD+KPSNLL+ + +K+ DFG++ +E Sbjct: 139 ARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVS----------NEFK 188 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKY--SRAMDVWSCGCILAELFLRRPIFPGRDYRHQ 231 G + ++ V T + APE + + K +A+DVW+ G L Sbjct: 189 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTL------------------ 230 Query: 232 LLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPM-YPAAPLEKMFPRVNPKGIDLLQRML 290 +FG P D + C+ S IKS + +P P + DL+ RML Sbjct: 231 YCFVFG--QCPFMDERIMCLHSK-----IKSQALEFPDQ------PDIAEDLKDLITRML 277 Query: 291 VFDPAKRITAKEALEHPYL 309 +P RI E HP++ Sbjct: 278 DKNPESRIVVPEIKLHPWV 296 >4APC-A nrPDB Length = 350 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 68/260 (26%), Positives = 119/260 (45%), Gaps = 32/260 (12%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR--TLREIKILKHFKHENIITIFN 76 +GEG++G G IK+I + R + RE+ +L + KH NI+ Sbjct: 32 IGEGSFGKAILVKSTEDGRQYVIKEIN-ISRMSSKEREESRREVAVLANMKHPNIV---- 86 Query: 77 IQRPDSFENFNEVYIIQELMQT-DLHRVISTQ---MLSDDHIQYFIYQTLRAVKVLHGSN 132 Q +SFE +YI+ + + DL + I+ Q + +D I + Q A+K +H Sbjct: 87 -QYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRK 145 Query: 133 VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPE 192 ++HRD+K N+ + + +++ DFG+AR+++ + G T +Y +PE Sbjct: 146 ILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIG----------TPYYLSPE 195 Query: 193 VMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP---HSDNDLR 249 + + Y+ D+W+ GC+L EL + F ++ +L I P H DLR Sbjct: 196 I-CENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLR 254 Query: 250 CIES------PRAREYIKSL 263 + S PR R + S+ Sbjct: 255 SLVSQLFKRNPRDRPSVNSI 274 >2W1I-A nrPDB Length = 326 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 69/208 (33%), Positives = 102/208 (49%), Gaps = 23/208 (11%) Query: 19 LGEGAYGVVCSATHKP----TGEIVAIKKIEPFDKPLFALRTL-REIKILKHFKHENIIT 73 LG+G +G V + P TGE+VA+KK++ + LR REI+ILK +H+NI+ Sbjct: 49 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HLRDFEREIEILKSLQHDNIVK 106 Query: 74 IFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIY--QTLRAVKVLHGS 131 + N I++ L L + DHI+ Y Q + ++ L Sbjct: 107 YKGVCYSAGRRNLK--LIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK 164 Query: 132 NVIHRDLKPSNLLINSNCDLKVCDFGLARII--DESAADNSEPTGQQSGMTEYVATRWYR 189 IHRDL N+L+ + +K+ DFGL +++ D+ EP G+ WY Sbjct: 165 RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEP-GES-------PIFWY- 215 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELF 217 APE LT +K+S A DVWS G +L ELF Sbjct: 216 APES-LTESKFSVASDVWSFGVVLYELF 242 >3IO7-A nrPDB Length = 313 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 69/208 (33%), Positives = 102/208 (49%), Gaps = 23/208 (11%) Query: 19 LGEGAYGVVCSATHKP----TGEIVAIKKIEPFDKPLFALRTL-REIKILKHFKHENIIT 73 LG+G +G V + P TGE+VA+KK++ + LR REI+ILK +H+NI+ Sbjct: 36 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HLRDFEREIEILKSLQHDNIVK 93 Query: 74 IFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIY--QTLRAVKVLHGS 131 + N I++ L L + DHI+ Y Q + ++ L Sbjct: 94 YKGVCYSAGRRNLK--LIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK 151 Query: 132 NVIHRDLKPSNLLINSNCDLKVCDFGLARII--DESAADNSEPTGQQSGMTEYVATRWYR 189 IHRDL N+L+ + +K+ DFGL +++ D+ EP G+ WY Sbjct: 152 RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEP-GES-------PIFWY- 202 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELF 217 APE LT +K+S A DVWS G +L ELF Sbjct: 203 APES-LTESKFSVASDVWSFGVVLYELF 229 >3QA8-A nrPDB Length = 676 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 64/224 (28%), Positives = 103/224 (45%), Gaps = 26/224 (11%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +++K LG G +G V H+ TGE VAIK+ P R EI+I+K H N++ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVV 75 Query: 73 TIFNIQRPDSFENF--NEV------YIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRA 124 + + PD + N++ Y ++ L++ + L + I+ + A Sbjct: 76 SAREV--PDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSA 133 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDL---KVCDFGLARIIDESAADNSEPTGQQSGMTE 181 ++ LH + +IHRDLKP N+++ K+ D G A+ +D+ TE Sbjct: 134 LRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGEL-----------CTE 182 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLR-RPIFP 224 +V T Y APE +L KY+ +D WS G + E RP P Sbjct: 183 FVGTLQYLAPE-LLEQKKYTVTVDYWSFGTLAFECITGFRPFLP 225 >6C9D-A nrPDB Length = 459 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 102/223 (45%), Gaps = 19/223 (8%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHE 69 +++L+ +G+G + V A H TG VA+K I+ P + RE++I+K H Sbjct: 21 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 80 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ +F + E +Y++ E +++ + + + Q + AV+ Sbjct: 81 NIVKLFEV-----IETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 135 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H ++HRDLK NLL++ + ++K+ DFG + N G + + E+ + Sbjct: 136 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFS---------NEFTVGNK--LDEFCGSPP 184 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 Y APE+ +DVWS G IL L F G++ + Sbjct: 185 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE 227 >3HKO-A nrPDB Length = 345 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 87/356 (24%), Positives = 141/356 (39%), Gaps = 90/356 (25%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK-----KIEPFDKPLFALRTLREIKIL 63 + + LK +G+G+YGVV A T I AIK KI + P R E++++ Sbjct: 24 LQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQIN-PKDVERIKTEVRLM 82 Query: 64 KHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-----------------LHRVIST 106 K H NI ++ + +E+ + ++ EL V+ T Sbjct: 83 KKLHHPNIARLYEV-----YEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKT 137 Query: 107 QML-------------------SDDHIQY------FIYQTLRAVKVLHGSNVIHRDLKPS 141 Q+ S D +Q + Q A+ LH + HRD+KP Sbjct: 138 QICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPE 197 Query: 142 NLLINSN--CDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM-LTSA 198 N L ++N ++K+ DFGL++ E N+ G+ GMT T ++ APEV+ T+ Sbjct: 198 NFLFSTNKSFEIKLVDFGLSK---EFYKLNN---GEYYGMTTKAGTPYFVAPEVLNTTNE 251 Query: 199 KYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRARE 258 Y D WS G +L L + FPG + + + N C E+P Sbjct: 252 SYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVL---------NKKLCFENPN--- 299 Query: 259 YIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHD 314 + ++P DLL +L + +R A AL+HP++ + D Sbjct: 300 ----------------YNVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSD 339 >3LM0-A nrPDB Length = 327 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 83/308 (26%), Positives = 131/308 (42%), Gaps = 56/308 (18%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA-LRTLREIKILKHFKHENIITIFNI 77 LG G + VV K TG+ A K ++ + L EI +L+ K + + N+ Sbjct: 37 LGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAK--SCPRVINL 94 Query: 78 QRPDSFENFNEVYIIQELMQTDLHRVIS------TQMLSDDHIQYFIYQTLRAVKVLHGS 131 + +EN +E+ +I E + S +M+S++ + I Q L V LH + Sbjct: 95 H--EVYENTSEIILILEYAAGG--EIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQN 150 Query: 132 NVIHRDLKPSNLLINSN---CDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 N++H DLKP N+L++S D+K+ DFG++R I G + E + T Y Sbjct: 151 NIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKI-----------GHACELREIMGTPEY 199 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 APE+ L + A D+W+ G I L F G D + L I + +S Sbjct: 200 LAPEI-LNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNI-SQVNVDYS---- 253 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 E+ F V+ D +Q +LV +P KR TA+ L H + Sbjct: 254 -----------------------EETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSW 290 Query: 309 LQTYHDPN 316 LQ + N Sbjct: 291 LQQWDFEN 298 >1VZO-A nrPDB Length = 355 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 74/312 (23%), Positives = 141/312 (45%), Gaps = 53/312 (16%) Query: 12 DFQLKSLLGEGAYG---VVCSATHKPTGEIVA---IKKIEPFDKPLFALRTLREIKILKH 65 +F+L +LG GAYG +V + TG++ A +KK K T E ++L+H Sbjct: 55 NFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEH 114 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLR 123 + + + +F+ ++++I + + + + ++ +Q ++ + + Sbjct: 115 IRQSPFLVTLHY----AFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVL 170 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 A++ LH +I+RD+K N+L++SN + + DFGL++ E AD +E G EY+ Sbjct: 171 ALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSK---EFVADETERAYDFCGTIEYM 227 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 A R + + + +A+D WS G ++ EL +P Sbjct: 228 APDIVRGGD-----SGHDKAVDWWSLGVLMYELLTG--------------------ASPF 262 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT---- 299 + + + ++ +R +KS P YP ++ DL+QR+L+ DP KR+ Sbjct: 263 TVDGEKNSQAEISRRILKSEPPYP--------QEMSALAKDLIQRLLMKDPKKRLGCGPR 314 Query: 300 -AKEALEHPYLQ 310 A E EH + Q Sbjct: 315 DADEIKEHLFFQ 326 >3ZUT-A nrPDB Length = 362 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 82/303 (27%), Positives = 126/303 (41%), Gaps = 46/303 (15%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 S ++L +G G +GV K + E+VA+K IE +K REI + +H Sbjct: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK--IDENVKREIINHRSLRHP 75 Query: 70 NIITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 NI+ I P E EL + R+ + S+D ++F Q + V Sbjct: 76 NIVRFKEVILTPTHLAIVMEYASGGELFE----RICNAGRFSEDEARFFFQQLISGVSYC 131 Query: 129 HGSNVIHRDLKPSNLLINSNCD--LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H V HRDLK N L++ + LK+C FG ++ S+ +S+P V T Sbjct: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSK----SSVLHSQPKST-------VGTP 180 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APEV+L + DVWSCG L + + +P D P Sbjct: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVG--AYPFED--------------PEEPK 224 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 + R + + L + A P + ++P+ L+ R+ V DPAKRI+ E H Sbjct: 225 NFR-------KTIHRILNVQYAIP---DYVHISPECRHLISRIFVADPAKRISIPEIRNH 274 Query: 307 PYL 309 + Sbjct: 275 EWF 277 >3DAK-A nrPDB Length = 290 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 77/309 (24%), Positives = 134/309 (43%), Gaps = 42/309 (13%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 D++L+ ++G GA VV +A P E VAIK+I L+EI+ + H NI Sbjct: 11 DYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNI 70 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQTD-----LHRVIS-----TQMLSDDHIQYFIYQT 121 ++ + SF +E++++ +L+ + +++ + +L + I + + Sbjct: 71 VSYYT-----SFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREV 125 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 L ++ LH + IHRD+K N+L+ + +++ DFG++ + A + T + T Sbjct: 126 LEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFL----ATGGDITRNKVRKT- 180 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 +V T + APEVM Y D+WS G EL P Y +L+ + Sbjct: 181 FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAA--PYHKYPPMKVLMLTLQND 238 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 P S + + ++Y KS + L+K DP KR TA Sbjct: 239 PPS-LETGVQDKEMLKKYGKSFRKMISLCLQK-------------------DPEKRPTAA 278 Query: 302 EALEHPYLQ 310 E L H + Q Sbjct: 279 ELLRHKFFQ 287 >2Z7Q-A nrPDB Length = 321 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 63/240 (26%), Positives = 120/240 (50%), Gaps = 23/240 (9%) Query: 11 SDFQLKSLLGEGAYG---VVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHF 66 S F+L +LG+G++G +V T +G + A+K ++ K +RT E IL Sbjct: 28 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADV 87 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQ-MLSDDHIQYFIYQTLRA 124 H ++ + +F+ ++Y+I + ++ DL +S + M +++ +++++ + Sbjct: 88 NHPFVVKLHY-----AFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALG 142 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + LH +I+RDLKP N+L++ +K+ DFGL++ A D+ + G EY+ Sbjct: 143 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSK----EAIDHEKKAYSFCGTVEYM- 197 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF-GIIGTPH 243 APEV + +S + D WS G ++ E+ F G+D + + LI +G P Sbjct: 198 -----APEV-VNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQ 251 >5FET-A nrPDB Length = 847 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 65/223 (29%), Positives = 108/223 (48%), Gaps = 20/223 (8%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 + + + ++G G +G V HKPT A+K + + + +L IK+ + EN Sbjct: 534 ELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSK--RSIISLNQQNNIKLEREITAEND 591 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI-STQMLSDDHIQYFIYQTLRAVKVLH 129 F I+ +F++ N Y + EL+ +L+ I +LS Q+++ + A++ LH Sbjct: 592 HP-FIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLH 650 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 N+++RDLKP N+L++ +K+ DFG A+ I Q V T Y Sbjct: 651 ERNIVYRDLKPENILLDKQGYVKLIDFGCAKKI-------------QGRAYTLVGTPHYM 697 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 APEV+L Y +D+W+ G L E F+ P+ G D QL Sbjct: 698 APEVILGKG-YGCTVDIWALGVCLYE-FICGPLPFGNDQEDQL 738 >3ALO-A nrPDB Length = 327 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 83/306 (27%), Positives = 129/306 (42%), Gaps = 51/306 (16%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +G GAYG V HKP+G+I+A+K+I + L ++ ++ I +Q Sbjct: 30 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYI----VQ 85 Query: 79 RPDSFENFNEVYIIQELMQTDLHRVIS-TQMLSDDHIQYFIYQ--TLRAVKVLH----GS 131 + + +I ELM T + + DD I I TL VK L+ Sbjct: 86 FYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENL 145 Query: 132 NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 +IHRD+KPSN+L++ + ++K+CDFG++ + +S A T R Y AP Sbjct: 146 KIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAK-----------TRDAGCRPYMAP 194 Query: 192 EVMLTSAK---YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 E + SA Y DVWS G L EL R +P + L Sbjct: 195 ERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLT-------------- 240 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 + +K P + E+ F +P I+ + L D +KR KE L+HP+ Sbjct: 241 ---------QVVKGDPPQLSNSEEREF---SPSFINFVNLCLTKDESKRPKYKELLKHPF 288 Query: 309 LQTYHD 314 + Y + Sbjct: 289 ILMYEE 294 >3MV5-A nrPDB Length = 342 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 80/320 (25%), Positives = 133/320 (41%), Gaps = 63/320 (19%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK--KIEPFDKPLFALRTLR 58 M R+ N +F+ LLG+G +G V K TG A+K K E TL Sbjct: 3 MDPRVTMN---EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT 59 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQY 116 E ++L++ +H + + SF+ + + + E + ++ S+D ++ Sbjct: 60 ENRVLQNSRHPFLTAL-----KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARF 114 Query: 117 FIYQTLRAVKVLHGS-NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQ 175 + + + A+ LH NV++RDLK NL+++ + +K+ DFGL + E Sbjct: 115 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK----------EGIKD 164 Query: 176 QSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLI 235 + M + T Y APEV L Y RA+D W G ++ E+ R F +D+ LI Sbjct: 165 GATMKTFCGTPEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 223 Query: 236 FGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR-VNPKGIDLLQRMLVFDP 294 +E R FPR + P+ LL +L DP Sbjct: 224 L--------------MEEIR-------------------FPRTLGPEAKSLLSGLLKKDP 250 Query: 295 AKRIT-----AKEALEHPYL 309 +R+ AKE ++H + Sbjct: 251 KQRLGGGSEDAKEIMQHRFF 270 >6CTH-A nrPDB Length = 309 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 25/235 (10%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 ++S+F ++ LGEG +G V + + +A+KK+ K E+KI+ +H Sbjct: 13 VTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIK-EYASEVKIISRLRH 71 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQT---DLHRVISTQMLSDDHIQYFIYQTL-RA 124 +N++ + E+ ++ E M D H +L+ + ++Y I + L A Sbjct: 72 KNLVKLIGWCHER-----GELMLVYEFMANGSLDSHIFKGKSLLTWE-VRYRIVKDLASA 125 Query: 125 VKVLHGSN---VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 + LH V+HRD+K SN++++S+ + K+ DFGLAR++D + T Sbjct: 126 LLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKK---------TL 176 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLI 235 T Y APE L+S K S+ DV+S G + E+ RR I P + LLL+ Sbjct: 177 LAGTVGYMAPEC-LSSGKASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLV 230 >2J90-A nrPDB Length = 304 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 80/319 (25%), Positives = 131/319 (41%), Gaps = 56/319 (17%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK-----KIEPFDKPLFALRTLREIKIL 63 + +++ LG G + +V K TG+ A K ++ + + RE+ IL Sbjct: 24 VEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNIL 83 Query: 64 KHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQT 121 + +H NIIT+ +I FEN +V +I EL+ + + L++D F+ Q Sbjct: 84 REIRHPNIITLHDI-----FENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQI 138 Query: 122 LRAVKVLHGSNVIHRDLKPSN-LLINSNC---DLKVCDFGLARIIDESAADNSEPTGQQS 177 L V LH + H DLKP N +L++ N +K+ DFG+A I+ A N Sbjct: 139 LDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIE---AGNE------- 188 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 T + APE+ + D+WS G I L F G + L I Sbjct: 189 -FKNIFGTPEFVAPEI-VNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISA 246 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 + + D D E+ F + D ++R+LV DP +R Sbjct: 247 V----NYDFD------------------------EEYFSNTSELAKDFIRRLLVKDPKRR 278 Query: 298 ITAKEALEHPYLQTYHDPN 316 +T ++LEH +++ N Sbjct: 279 MTIAQSLEHSWIKAIRRRN 297 >5KCV-A nrPDB Length = 460 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 78/310 (25%), Positives = 131/310 (42%), Gaps = 60/310 (19%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK--KIEPFDKPLFALRTLREIKILKHFKH 68 ++F+ LLG+G +G V K TG A+K K E TL E ++L++ +H Sbjct: 162 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 221 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 + + SF+ + + + E + ++ S+D +++ + + A+ Sbjct: 222 PFLTAL-----KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 276 Query: 127 VLHGS-NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 LH NV++RDLK NL+++ + +K+ DFGL + E D + M + T Sbjct: 277 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK---EGIKDGAT-------MKTFCGT 326 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Y APEV L Y RA+D W G ++ E+ R F +D+ LI Sbjct: 327 PEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL--------- 376 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPR-VNPKGIDLLQRMLVFDPAKRIT----- 299 +E R FPR + P+ LL +L DP +R+ Sbjct: 377 -----MEEIR-------------------FPRTLGPEAKSLLSGLLKKDPKQRLGGGSED 412 Query: 300 AKEALEHPYL 309 AKE ++H + Sbjct: 413 AKEIMQHRFF 422 >1KOB-A nrPDB Length = 387 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 74/301 (24%), Positives = 129/301 (42%), Gaps = 53/301 (17%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77 LG GA+GVV K TG + K I P+ PL EI I+ H +I + Sbjct: 59 LGSGAFGVVHRCVEKATGRVFVAKFINTPY--PLDKYTVKNEISIMNQLHHPKLINLH-- 114 Query: 78 QRPDSFENFNEVYIIQELMQT-DLHRVISTQ--MLSDDHIQYFIYQTLRAVKVLHGSNVI 134 D+FE+ E+ +I E + +L I+ + +S+ + ++ Q +K +H +++ Sbjct: 115 ---DAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSIV 171 Query: 135 HRDLKPSNLLINSN--CDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPE 192 H D+KP N++ + +K+ DFGLA ++ + AT + APE Sbjct: 172 HLDIKPENIMCETKKASSVKIIDFGLATKLNPDEI-----------VKVTTATAEFAAPE 220 Query: 193 VMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIE 252 + + D+W+ G + L F G D DL ++ Sbjct: 221 I-VDREPVGFYTDMWAIGVLGYVLLSGLSPFAGED-------------------DLETLQ 260 Query: 253 SPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTY 312 + + ++ E F V+P+ D ++ +L +P KR+T +ALEHP+L+ Sbjct: 261 NVKRCDWEFD---------EDAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGD 311 Query: 313 H 313 H Sbjct: 312 H 312 >3HDN-A nrPDB Length = 373 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 102/225 (45%), Gaps = 27/225 (12%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 SDF ++G+G++G V A HK A+K ++ + + + K KH E Sbjct: 38 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQK--------KAILKKKEEKHIMSER 89 Query: 71 IITIFNIQRPD------SFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTL 122 + + N++ P SF+ +++Y + + + + + + + +++ + Sbjct: 90 NVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIA 149 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 A+ LH N+++RDLKP N+L++S + + DFGL + E S + + Sbjct: 150 SALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCK----------ENIEHNSTTSTF 199 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 T Y APEV L Y R +D W G +L E+ P F R+ Sbjct: 200 CGTPEYLAPEV-LHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRN 243 >4I6B-A nrPDB Length = 308 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 101/209 (48%), Gaps = 20/209 (9%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKHENIITIFN 76 LG+G + T ++ A K I KP + +EI++ + H++++ ++ Sbjct: 36 LGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKHVVQFYH 95 Query: 77 IQRPDSFENFNEVYIIQELM--QTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVI 134 FE+ +YI+ E ++ H + + ++L++ ++Y++ Q + +K LH ++ Sbjct: 96 Y-----FEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEIL 150 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 HRDLK N IN + +LKV DFGLA + EP + T Y +PEV Sbjct: 151 HRDLKLGNFFINESMELKVGDFGLAARL--------EPLEHRRRTI--CGTPNYLSPEV- 199 Query: 195 LTSAKYSRAMDVWSCGCILAELFLRRPIF 223 L + D+W+ GC++ + L RP F Sbjct: 200 LNKQGHGAESDIWALGCVMYTMLLGRPPF 228 >2HAK-A nrPDB Length = 328 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 101/222 (45%), Gaps = 19/222 (8%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHE 69 +++L+ +G+G + V A H TG VA+K I+ P + RE++I+K H Sbjct: 15 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 74 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ +F + E +Y++ E +++ + + + Q + AV+ Sbjct: 75 NIVKLFEV-----IETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 129 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H ++HRDLK NLL++ + ++K+ DFG + +E N T + + Sbjct: 130 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFS---NEFTVGNKLDT--------FCGSPP 178 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 Y APE+ +DVWS G IL L F G++ + Sbjct: 179 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLK 220 >2JDO-A nrPDB Length = 342 Score = 80.5 bits (197), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 73/309 (23%), Positives = 133/309 (43%), Gaps = 59/309 (19%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK--KIEPFDKPLFALRTLREIKILKHFKH 68 +DF LLG+G +G V K TG A+K + E T+ E ++L++ +H Sbjct: 10 NDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRH 69 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 + + +F+ + + + E + ++ +++ +++ + + A++ Sbjct: 70 PFLTAL-----KYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 124 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH +V++RD+K NL+++ + +K+ DFGL + E +D + M + T Sbjct: 125 YLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCK---EGISDGAT-------MKTFCGTP 174 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APEV L Y RA+D W G ++ E+ R F +D+ LI Sbjct: 175 EYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL---------- 223 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPR-VNPKGIDLLQRMLVFDPAKRIT-----A 300 +E R FPR ++P+ LL +L DP +R+ A Sbjct: 224 ----MEEIR-------------------FPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDA 260 Query: 301 KEALEHPYL 309 KE +EH + Sbjct: 261 KEVMEHRFF 269 >5DBX-A nrPDB Length = 328 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 59/214 (27%), Positives = 103/214 (48%), Gaps = 20/214 (9%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 ++L+ ++G GA VV +A KP E VAIK+I L+EI+ + H N++ Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVV 72 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQT----DLHRVISTQ------MLSDDHIQYFIYQTL 122 T + SF +E++++ +L+ D+ + I + +L + I + + L Sbjct: 73 TYYT-----SFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVL 127 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + LH + IHRDLK N+L+ + +++ DFG++ + A + T + ++ Sbjct: 128 EGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFL----ATGGDVT-RNKVRKDF 182 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 V T + APEVM Y D+WS G EL Sbjct: 183 VGTPCWMAPEVMEQVRGYDFKADMWSFGITAIEL 216 >5D9K-A nrPDB Length = 330 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 65/295 (22%), Positives = 142/295 (48%), Gaps = 46/295 (15%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREI------KIL 63 S F+L +LG+G++G ++ +KKI D + L+A++ L++ ++ Sbjct: 30 SQFELLKVLGQGSFG-----------KVFLVKKISGSDARQLYAMKVLKKATLKVRDRVR 78 Query: 64 KHFKHENIITI---FNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQ-MLSDDHIQYFI 118 + + ++ + F ++ +F+ ++Y+I + ++ DL +S + M +++ +++++ Sbjct: 79 TKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYL 138 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 + A+ LH +I+RDLKP N+L++ +K+ DFGL++ E + Sbjct: 139 AELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSK----------ESIDHEKK 188 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF-G 237 + T Y APEV + ++++ D WS G ++ E+ F G+D + + +I Sbjct: 189 AYSFCGTVEYMAPEV-VNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKA 247 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 +G P SP A+ ++ L + P ++ P G++ ++R F Sbjct: 248 KLGMPQ-------FLSPEAQSLLRML--FKRNPANRL--GAGPDGVEEIKRHSFF 291 >1JPA-A nrPDB Length = 312 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 67/217 (30%), Positives = 102/217 (47%), Gaps = 25/217 (11%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGE---IVAIKKIEPFDKPLFALRTLREIKILKHFK 67 S +++ ++G G +G VCS K G+ VAIK ++ L E I+ F Sbjct: 33 SCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFD 92 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ---TLRA 124 H N+I + + + V II E M+ L + Q+ + Q LR Sbjct: 93 HPNVIHLEGVVTKST-----PVMIITEFMENGSL----DSFLRQNDGQFTVIQLVGMLRG 143 Query: 125 V----KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 + K L N +HRDL N+L+NSN KV DFGL+R +++ D S+PT S + Sbjct: 144 IAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLED---DTSDPT-YTSALG 199 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 + RW APE + K++ A DVWS G ++ E+ Sbjct: 200 GKIPIRW-TAPEA-IQYRKFTSASDVWSYGIVMWEVM 234 >2VWV-A nrPDB Length = 302 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 65/220 (29%), Positives = 105/220 (47%), Gaps = 23/220 (10%) Query: 14 QLKSLLGEGAYGVVCSATHKPTGE---IVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +++ ++G G +G VC K G+ VAIK ++ L E I+ F+H N Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPN 78 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYF-IYQTLRAV---- 125 II + + N V I+ E M+ + S L+D + LR + Sbjct: 79 IIRLEGV-----VTNSMPVMILTEFMENGA--LDSFLRLNDGQFTVIQLVGMLRGIASGM 131 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 + L + +HRDL N+L+NSN KV DFGL+R ++E+++D +E S + + Sbjct: 132 RYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTE----TSSLGGKIPI 187 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAEL--FLRRPIF 223 RW APE + K++ A D WS G ++ E+ F RP + Sbjct: 188 RWT-APEA-IAFRKFTSASDAWSYGIVMWEVMSFGERPYW 225 >4L42-A nrPDB Length = 346 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 80/315 (25%), Positives = 139/315 (44%), Gaps = 69/315 (21%) Query: 13 FQLKSLLGEGAYGVVCSA---THKPTGEIVAIKKIEPFDKPLFALR-------TLREIKI 62 F+L +LG+G YG V T TG+I A+K + K +R T E I Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVL----KKAMIVRNAKDTAHTKAERNI 75 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQ 120 L+ KH I+ + +F+ ++Y+I E + ++ + +D +++ + Sbjct: 76 LEEVKHPFIVDLIY-----AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAE 130 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 A+ LH +I+RDLKP N+++N +K+ DFGL + ES D + T G Sbjct: 131 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCK---ESIHDGT-VTHTFCGTI 186 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 EY+ APE+++ S ++RA+D WS G ++ ++ P F G + + + Sbjct: 187 EYM------APEILMRSG-HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTI-------- 231 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT- 299 D L+C +LP P + + DLL+++L + A R+ Sbjct: 232 ----DKILKC---------KLNLP-----------PYLTQEARDLLKKLLKRNAASRLGA 267 Query: 300 ----AKEALEHPYLQ 310 A E HP+ + Sbjct: 268 GPGDAGEVQAHPFFR 282 >3UDB-A nrPDB Length = 317 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 81/303 (26%), Positives = 125/303 (41%), Gaps = 46/303 (15%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 S ++L +G G +GV K E+VA+K IE +K REI + +H Sbjct: 18 SDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEK--IDENVKREIINHRSLRHP 75 Query: 70 NIITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 NI+ I P E EL + R+ + S+D ++F Q + V Sbjct: 76 NIVRFKEVILTPTHLAIVMEYASGGELFE----RICNAGRFSEDEARFFFQQLISGVSYA 131 Query: 129 HGSNVIHRDLKPSNLLINSNCD--LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H V HRDLK N L++ + LK+ DFG ++ ++ +S+P V T Sbjct: 132 HAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSK----ASVLHSQPKSA-------VGTP 180 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APEV+L + DVWSCG L + + +P D P Sbjct: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV--GAYPFED--------------PEEPK 224 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 + R + + L + A P + ++P+ L+ R+ V DPAKRI+ E H Sbjct: 225 NFR-------KTIHRILNVQYAIP---DYVHISPECRHLISRIFVADPAKRISIPEIRNH 274 Query: 307 PYL 309 + Sbjct: 275 EWF 277 >1TKI-A nrPDB Length = 321 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 138/300 (46%), Gaps = 58/300 (19%) Query: 19 LGEGAYGVV--CSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFN 76 LG G +G+V C T + K++ D+ L +EI IL +H NI+ + Sbjct: 13 LGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVK----KEISILNIARHRNILHL-- 66 Query: 77 IQRPDSFENFNEVYIIQELMQT-DLHRVISTQM--LSDDHIQYFIYQTLRAVKVLHGSNV 133 +SFE+ E+ +I E + D+ I+T L++ I +++Q A++ LH N+ Sbjct: 67 ---HESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNI 123 Query: 134 IHRDLKPSNLLINS--NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 H D++P N++ + + +K+ +FG AR + DN + A +Y AP Sbjct: 124 GHFDIRPENIIYQTRRSSTIKIIEFGQARQL--KPGDNFRLL--------FTAPEYY-AP 172 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH-SDNDLRC 250 EV S A D+WS G ++ +L+ GI P ++ + + Sbjct: 173 EVHQHDV-VSTATDMWSLGTLV------------------YVLLSGI--NPFLAETNQQI 211 Query: 251 IESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 IE+ EY E+ F ++ + +D + R+LV + R+TA EAL+HP+L+ Sbjct: 212 IENIMNAEYTFD---------EEAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLK 262 >5H2U-A nrPDB Length = 267 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 69/219 (31%), Positives = 100/219 (45%), Gaps = 23/219 (10%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 +F L LG G +G V K + VAIK I D L EI+ +K +H++I Sbjct: 7 EFTLCRKLGSGYFGEVFEGLWKDRVQ-VAIKVISR-DNLLHQQMLQSEIQAMKKLRHKHI 64 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQT----DLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 + ++ + + VYII ELM +L R ++L + +Q + Sbjct: 65 LALYAV-----VSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCY 119 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 L N IHRDL N+L+ N KV DFGLAR+I E + + + +W Sbjct: 120 LESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHN---------IPYKW 170 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPI-FPG 225 APE L+ YS DVWS G +L E+F R + +PG Sbjct: 171 -TAPEA-LSRGHYSTKSDVWSFGILLHEMFSRGQVPYPG 207 >5F9E-A nrPDB Length = 353 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 76/327 (23%), Positives = 145/327 (44%), Gaps = 62/327 (18%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR-----TLREIKILK- 64 DF+L +LG+G++G V A K T + AIK ++ K + + T+ E ++L Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALK---KDVVLMDDDVECTMVEKRVLSL 75 Query: 65 HFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTL 122 ++H + +F +F+ ++ + E + ++ + S ++ + + Sbjct: 76 AWEHPFLTHMFC-----TFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEII 130 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 ++ LH +++RDLK N+L++ + +K+ DFG+ + E + E+ Sbjct: 131 LGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCK----------ENMLGDAKTNEF 180 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 T Y APE++L KY+ ++D WS G +L E+ + + F G+D + + Sbjct: 181 CGTPDYIAPEILL-GQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEE-------LFHSI 232 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 DN P YP LEK + DLL ++ V +P KR+ + Sbjct: 233 RMDN-----------------PFYPRW-LEK-------EAKDLLVKLFVREPEKRLGVRG 267 Query: 303 AL-EHPYLQTYHDPNDEPEGEPIPPSF 328 + +HP + + +E E + I P F Sbjct: 268 DIRQHPLFREIN--WEELERKEIDPPF 292 >3GUB-A nrPDB Length = 295 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 78/314 (24%), Positives = 129/314 (41%), Gaps = 56/314 (17%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTG-----EIVAIKKIEPFDKPLFALRTLREIKI 62 N+ + LG G + VV K TG + + ++ + + + RE+ I Sbjct: 8 NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSI 67 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQ 120 LK +H N+IT+ + +EN +V +I EL+ + + L+++ F+ Q Sbjct: 68 LKEIQHPNVITLHEV-----YENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQ 122 Query: 121 TLRAVKVLHGSNVIHRDLKPSN-LLINSNC---DLKVCDFGLARIIDESAADNSEPTGQQ 176 L V LH + H DLKP N +L++ N +K+ DFGLA ID G + Sbjct: 123 ILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKID---------FGNE 173 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 T + APE+ + D+WS G I L F G D + + L Sbjct: 174 --FKNIFGTPEFVAPEI-VNYEPLGLEADMWSIGVITYILLSGASPFLG-DTKQETLANV 229 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAK 296 + D EY F + D ++R+LV DP K Sbjct: 230 SAVNYEFED------------EY---------------FSNTSALAKDFIRRLLVKDPKK 262 Query: 297 RITAKEALEHPYLQ 310 R+T +++L+HP+++ Sbjct: 263 RMTIQDSLQHPWIK 276 >4RLP-A nrPDB Length = 288 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 84/337 (24%), Positives = 145/337 (43%), Gaps = 71/337 (21%) Query: 13 FQLKSLLGEGAYGVVCSA---THKPTGEIVAIKKIEP---FDKPLFALRTLREIKILKHF 66 F+L +LG+G YG V T TG+I A+K ++ T E IL+ Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 66 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRA 124 KH I+ + +F+ ++Y+I E + ++ + +D +++ + A Sbjct: 67 KHPFIVDLIY-----AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMA 121 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + LH +I+RDLKP N+++N +K+ DFGL + ES D + T G EY+ Sbjct: 122 LGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCK---ESIHDGT-VTHTFCGTIEYM- 176 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 APE+++ S ++RA+D WS G ++ ++ P F G + + + Sbjct: 177 -----APEILMRSG-HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTI------------ 218 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 D L+C +LP P + + DLL+++L + A R+ A Sbjct: 219 DKILKC---------KLNLP-----------PYLTQEARDLLKKLLKRNAASRLGA---- 254 Query: 305 EHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTK 341 P D E + P FF +++E L K Sbjct: 255 ---------GPGDAGEVQAHP--FFRHINWEELLARK 280 >5DYK-A nrPDB Length = 853 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 63/223 (28%), Positives = 106/223 (47%), Gaps = 20/223 (8%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 + + + ++G G +G V HKPT A+K + + + L IK+ + EN Sbjct: 540 ELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSK--RSIINLNQQNNIKLEREITAEND 597 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI-STQMLSDDHIQYFIYQTLRAVKVLH 129 F I+ +F++ Y + EL+ +L+ I +LS Q+++ + A++ LH Sbjct: 598 HP-FIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLH 656 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 N+++RDLKP N+L++ +K+ DFG A+ + Q V T Y Sbjct: 657 ERNIVYRDLKPENILLDKQGYVKLIDFGCAKKV-------------QGRAYTLVGTPHYM 703 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 APEV+L Y +D+W+ G L E F+ P+ G D QL Sbjct: 704 APEVILGKG-YGCTVDIWALGICLYE-FICGPLPFGNDEEDQL 744 >2RIO-A nrPDB Length = 434 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 78/315 (24%), Positives = 136/315 (43%), Gaps = 60/315 (19%) Query: 16 KSLLGEGAYG-VVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HENIIT 73 + +LG G+ G VV + + G VA+K++ D F L EIK+L H N+I Sbjct: 20 EKILGYGSSGTVVFQGSFQ--GRPVAVKRM-LID---FCDIALMEIKLLTESDDHPNVIR 73 Query: 74 IFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQY--------FIYQTLRAV 125 + + D F +YI EL +L ++ ++ +SD++++ + Q V Sbjct: 74 YYCSETTDRF-----LYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGV 128 Query: 126 KVLHGSNVIHRDLKPSNLLINS-------------NCDLKVCDFGLARIIDESAADNSEP 172 LH +IHRDLKP N+L+++ N + + DFGL + +D + Sbjct: 129 AHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTN 188 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 SG + + A + T + +R++D++S GC+ + + G Y + Sbjct: 189 LNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRES 248 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 +I GI S ++++C+ R I + DL+ +M+ Sbjct: 249 NIIRGIF----SLDEMKCLHD---RSLI-------------------AEATDLISQMIDH 282 Query: 293 DPAKRITAKEALEHP 307 DP KR TA + L HP Sbjct: 283 DPLKRPTAMKVLRHP 297 >3PPZ-A nrPDB Length = 309 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 98/211 (46%), Gaps = 22/211 (10%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRT---LREIKILKHFKH 68 D +K +G G++G V A G VA+K + ++ A R LRE+ I+K +H Sbjct: 38 DLNIKEKIGAGSFGTVHRAEWH--GSDVAVKIL--MEQDFHAERVNEFLREVAIMKRLRH 93 Query: 69 ENIITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ + +P + E Y+ + + LH+ + + L + Y + + Sbjct: 94 PNIVLFMGAVTQPPNLSIVTE-YLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNY 152 Query: 128 LHGSN--VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 LH N ++HRDLK NLL++ +KVCDFGL+R+ + + G M Sbjct: 153 LHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWM------ 206 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 APEV+ ++ DV+S G IL EL Sbjct: 207 ----APEVLRDEPSNEKS-DVYSFGVILWEL 232 >4B8L-A nrPDB Length = 286 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 76/315 (24%), Positives = 132/315 (41%), Gaps = 56/315 (17%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLR 58 MPKR + I DF + LG+G +G V A K I+A+K + +K + R Sbjct: 7 MPKR-KFTID-DFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRR 64 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDHIQY- 116 EI+I H +H NI+ ++N F + +Y++ E + +L++ + D+ Sbjct: 65 EIEIQSHLRHPNILRMYNY-----FHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSAT 119 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 F+ + A+ H VIHRD+KP NLL+ +LK+ DFG + P+ ++ Sbjct: 120 FMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWS---------VHAPSLRR 170 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 M T Y PE M+ + +D+W G + E + P F Sbjct: 171 RTM---CGTLDYLPPE-MIEGKTHDEKVDLWCAGVLCYEFLVGMPPFD------------ 214 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAK 296 H++ R + K P ++ DL+ ++L + P + Sbjct: 215 ---SPSHTETHRRIVNVDL-----------------KFPPFLSDGSKDLISKLLRYHPPQ 254 Query: 297 RITAKEALEHPYLQT 311 R+ K +EHP+++ Sbjct: 255 RLPLKGVMEHPWVKA 269 >3QD2-B nrPDB Length = 332 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 69/266 (25%), Positives = 107/266 (40%), Gaps = 60/266 (22%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +DF+ +G G +GVV A +K AIK+I ++ L + +RE+K L +H Sbjct: 6 TDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 65 Query: 71 IITIFN----------------------------------------IQRPDSFENFNEV- 89 I+ FN I+R D F N V Sbjct: 66 IVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVG 125 Query: 90 -----------YIIQELMQTD-----LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNV 133 YI +L + + ++R S + + Q AV+ LH + Sbjct: 126 QLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGL 185 Query: 134 IHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS--EPTGQQSGMTEYVATRWYRAP 191 +HRDLKPSN+ + +KV DFGL +D+ + + P + T V T+ Y +P Sbjct: 186 MHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSP 245 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELF 217 E + YS +D++S G IL EL Sbjct: 246 E-QIHGNNYSHKVDIFSLGLILFELL 270 >4GS6-A nrPDB Length = 315 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 68/221 (30%), Positives = 98/221 (44%), Gaps = 35/221 (15%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 + +++ ++G GA+GVVC A K + VAIK+IE + + LR+ L H NI Sbjct: 10 EIEVEEVVGRGAFGVVCKA--KWRAKDVAIKQIESESERKAFIVELRQ---LSRVNHPNI 64 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQTD-----LHRVISTQMLSDDHIQYFIYQTLRAVK 126 + ++ N V ++ E + LH + H + Q + V Sbjct: 65 VKLYG-------ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 117 Query: 127 VLHG---SNVIHRDLKPSN-LLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 LH +IHRDLKP N LL+ LK+CDFG A I Q+ MT Sbjct: 118 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI-------------QTHMTNN 164 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 + + APEV + YS DV+S G IL E+ RR F Sbjct: 165 KGSAAWMAPEV-FEGSNYSEKCDVFSWGIILWEVITRRKPF 204 >4WB7-A nrPDB Length = 405 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 109/220 (49%), Gaps = 33/220 (15%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR----TLREIKILKHFKH 68 F+ LG G++G V HK TG A+K ++ + + L+ TL E +IL Sbjct: 98 FERIKTLGTGSFGRVMLVKHKETGNHYAMKILDK--QKVVKLKQIEHTLNEKRIL----- 150 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQEL-----MQTDLHRVISTQMLSDDHIQYFIYQTLR 123 + + F ++ SF++ + +Y++ E M + L R+ S+ H +++ Q + Sbjct: 151 QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRI---GRFSEPHARFYAAQIVL 207 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 + LH ++I+RDLKP NLLI+ ++V DFG A+ + T G EY+ Sbjct: 208 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR-------TWTLCGTPEYL 260 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 APE++L+ Y++A+D W+ G ++ E+ P F Sbjct: 261 ------APEIILSKG-YNKAVDWWALGVLIYEMAAGYPPF 293 >4E93-A nrPDB Length = 377 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 90/209 (43%), Gaps = 17/209 (8%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 D L +G G +G V S + +VA+K P + L+E +ILK + H NI Sbjct: 115 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNI 174 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQ--MLSDDHIQYFIYQTLRAVKVL 128 + + + +YI+ EL+Q D + T+ L + + ++ L Sbjct: 175 VRLIGV-----CTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYL 229 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 IHRDL N L+ LK+ DFG++R + ++ SG V +W Sbjct: 230 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSR-------EEADGVYAASGGLRQVPVKW- 281 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELF 217 APE L +YS DVWS G +L E F Sbjct: 282 TAPEA-LNYGRYSSESDVWSFGILLWETF 309 >2H8H-A nrPDB Length = 535 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 106/226 (46%), Gaps = 24/226 (10%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 +L+ LG+G +G V T T VAIK ++P A L+E +++K +HE + Sbjct: 268 SLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAF--LQEAQVMKKLRHEKL 324 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQT----DLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 + ++ + + +YI+ E M D + + + L + Q + Sbjct: 325 VQLYAVVSEEP------IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 378 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 + N +HRDL+ +N+L+ N KV DFGLAR+I +++E T +Q +W Sbjct: 379 VERMNYVHRDLRAANILVGENLVCKVADFGLARLI-----EDNEYTARQGAK---FPIKW 430 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLR-RPIFPGRDYRHQL 232 APE L +++ DVWS G +L EL + R +PG R L Sbjct: 431 -TAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL 474 >6BXI-A nrPDB Length = 333 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 116/244 (47%), Gaps = 41/244 (16%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 DF+ ++G GA+G V K TG + A+K + D + E + + H + E Sbjct: 7 DFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKAD--------MLEKEQVGHIRAERD 58 Query: 72 I-----TIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRA 124 I +++ ++ SF++ +Y+I E + + ++ L+++ Q++I +T+ A Sbjct: 59 ILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLA 118 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDES-------AADNSEPTG--Q 175 + +H IHRD+KP NLL++S +K+ DFGL + ++ ++S P+ Sbjct: 119 IDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTF 178 Query: 176 QSGMTEYVATRWYR----------------APEVMLTSAKYSRAMDVWSCGCILAELFLR 219 Q+ ++ A W R APEV + + Y++ D WS G I+ E+ + Sbjct: 179 QNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-YNKLCDWWSLGVIMYEMLIG 237 Query: 220 RPIF 223 P F Sbjct: 238 YPPF 241 >4KIK-B nrPDB Length = 677 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 62/224 (27%), Positives = 103/224 (45%), Gaps = 26/224 (11%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +++K LG G +G V ++ TGE +AIK+ P R EI+I++ H N++ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 80 Query: 73 TIFNIQRPDSFENF--NEV------YIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRA 124 ++ P+ +N N++ Y ++ L++ + L + I + A Sbjct: 81 AARDV--PEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASA 138 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDL---KVCDFGLARIIDESAADNSEPTGQQSGMTE 181 ++ LH + +IHRDLKP N+++ K+ D G A+ +D Q S T Sbjct: 139 LRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELD-----------QGSLCTS 187 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLR-RPIFP 224 +V T Y APE +L KY+ +D WS G + E RP P Sbjct: 188 FVGTLQYLAPE-LLEQQKYTVTVDYWSFGTLAFECITGFRPFLP 230 >6F3F-A nrPDB Length = 455 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 106/226 (46%), Gaps = 24/226 (10%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 +L+ LG+G +G V T T VAIK ++P A L+E +++K +HE + Sbjct: 188 SLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAF--LQEAQVMKKLRHEKL 244 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQT----DLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 + ++ + + +YI+ E M D + + + L + Q + Sbjct: 245 VQLYAVVSEEP------IYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAY 298 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 + N +HRDL+ +N+L+ N KV DFGLAR+I +++E T +Q +W Sbjct: 299 VERMNYVHRDLRAANILVGENLVCKVADFGLARLI-----EDNEYTARQGAK---FPIKW 350 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLR-RPIFPGRDYRHQL 232 APE L +++ DVWS G +L EL + R +PG R L Sbjct: 351 -TAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL 394 >6ED6-A nrPDB Length = 415 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 52/217 (23%), Positives = 104/217 (47%), Gaps = 24/217 (11%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 + D+ + ++G GA+G V HK + ++ A+K + F+ ++ ++ Sbjct: 87 AEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFE-------MIKRSDSAFFWEER 139 Query: 70 NIITIFN----IQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDHIQYFIYQTLRA 124 +I+ N +Q +F++ +Y++ E M DL ++S + + +++ + + A Sbjct: 140 DIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLA 199 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + +H +IHRD+KP N+L++ + LK+ DFG +DE+ + + V Sbjct: 200 LDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTA---------VG 250 Query: 185 TRWYRAPEVMLTSAK---YSRAMDVWSCGCILAELFL 218 T Y +PEV+ + Y R D WS G L E+ + Sbjct: 251 TPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV 287 >2XIK-A nrPDB Length = 294 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 79/295 (26%), Positives = 124/295 (42%), Gaps = 48/295 (16%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +G+G++G V T E+VAIK I+ + +EI +L I F Sbjct: 27 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFG-- 84 Query: 79 RPDSFENFNEVYIIQE-LMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 S+ +++II E L ++ L + +I + + L+ + LH IHRD Sbjct: 85 ---SYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRD 141 Query: 138 LKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTS 197 +K +N+L++ D+K+ DFG+A + T Q +V T ++ APEV+ S Sbjct: 142 IKAANVLLSEQGDVKLADFGVA----------GQLTDTQIKRNTFVGTPFWMAPEVIKQS 191 Query: 198 AKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAR 257 A Y D+WS G EL P P D H + ++F I P + SP Sbjct: 192 A-YDFKADIWSLGITAIELAKGEP--PNSDL-HPMRVLFLI---PKN--------SPPTL 236 Query: 258 EYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTY 312 E S P + ++ L DP R TAKE L+H ++ Y Sbjct: 237 EGQHSKPFK-----------------EFVEACLNKDPRFRPTAKELLKHKFITRY 274 >4EQM-A nrPDB Length = 294 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 62/222 (27%), Positives = 99/222 (44%), Gaps = 19/222 (8%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHF 66 I+ +++ LG G V A VAIK I P +K R RE+ Sbjct: 9 INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQL 68 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQ--TDLHRVISTQMLSDDHIQYFIYQTLRA 124 H+NI+++ ++ D Y++ E ++ T + S LS D F Q L Sbjct: 69 SHQNIVSMIDVDEEDDC-----YYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDG 123 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 +K H ++HRD+KP N+LI+SN LK+ DFG+A+ + E++ + + Sbjct: 124 IKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQT---------NHVLG 174 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGR 226 T Y +PE A D++S G +L E+ + P F G Sbjct: 175 TVQYFSPEQAKGEAT-DECTDIYSIGIVLYEMLVGEPPFNGE 215 >5N23-A nrPDB Length = 352 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 61/223 (27%), Positives = 108/223 (48%), Gaps = 38/223 (17%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 F+ LG G++G V HK TG A+K ++ + + ++K ++H +E I Sbjct: 44 FERIRTLGTGSFGRVMLVKHKETGNHYAMKILDK--------QKVVKLKQIEHTLNEKRI 95 Query: 73 TI-----FNIQRPDSFENFNEVYIIQEL-----MQTDLHRVISTQMLSDDHIQYFIYQTL 122 F ++ SF++ + +Y++ E M + L R+ S+ H +++ Q + Sbjct: 96 QQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRI---GRFSEPHARFYAAQIV 152 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + LH ++I+RDLKP NLLI+ +KV DFG A+ + G T + Sbjct: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRV--------------KGRTPW 198 Query: 183 V--ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 T Y APE++L+ Y++A+D W+ G ++ E+ P F Sbjct: 199 TLCGTPEYLAPEIILSKG-YNKAVDWWALGVLIYEMAAGYPPF 240 >6HXF-B nrPDB Length = 302 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 100/211 (47%), Gaps = 23/211 (10%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +++ LG+GA+G V A +K TG + A K IE + + EI+IL H I+ Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELE-DYIVEIEILATCDHPYIV 79 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM---LSDDHIQYFIYQTLRAVKVLH 129 + ++ + +++I+ E I ++ L++ IQ Q L A+ LH Sbjct: 80 KLLG-----AYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLH 134 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 +IHRDLK N+L+ D+++ DFG+ +A N + ++ ++ T ++ Sbjct: 135 SKRIIHRDLKAGNVLMTLEGDIRLADFGV-------SAKNLKTLQKRDS---FIGTPYWM 184 Query: 190 APEVMLTSAK----YSRAMDVWSCGCILAEL 216 APEV++ Y D+WS G L E+ Sbjct: 185 APEVVMCETMKDTPYDYKADIWSLGITLIEM 215 >5MJB-A nrPDB Length = 305 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 70/225 (31%), Positives = 103/225 (45%), Gaps = 33/225 (14%) Query: 14 QLKSLLGEGAYGVVCSATHKPTGE---IVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +++ ++G G +G V K G+ VAIK ++ L E I+ F H N Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHRN 88 Query: 71 IITIFNI---QRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ---TLRA 124 II + + RP V II E M+ L + Q+ + Q LR Sbjct: 89 IIRLEGVVTKSRP--------VMIITEFMEN----CALDSFLRQNDGQFTVIQLVGMLRG 136 Query: 125 V----KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 + K L N +HRDL N+L+NSN KV DFGL+R + + D S+PT S + Sbjct: 137 IAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQD---DTSDPT-YTSSLG 192 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL--FLRRPIF 223 + RW APE + K++ A DVWS G ++ E+ F RP + Sbjct: 193 GKIPVRW-TAPEA-IAYRKFTSASDVWSYGIVMWEVMSFGERPYW 235 >5L6P-A nrPDB Length = 298 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/216 (29%), Positives = 99/216 (45%), Gaps = 23/216 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGE---IVAIKKIEPFDKPLFALRTLREIKILKHFK 67 S +++ ++G G +G VC K G VAIK ++ L E I+ F Sbjct: 19 SCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFD 78 Query: 68 HENIITIFNI---QRPDSFENFNEVYIIQELMQT---DLHRVISTQMLSDDHIQYFIYQT 121 H NII + + RP V I+ E M+ D ++ + + + Sbjct: 79 HPNIIRLEGVVTKSRP--------VMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGI 130 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 +K L N +HRDL N+L+NSN KV DFGL+R +++ D S+PT S + Sbjct: 131 AAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLED---DPSDPT-YTSSLGG 186 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 + RW APE + K++ A DVWS G ++ E+ Sbjct: 187 KIPIRWT-APEA-IAYRKFTSASDVWSYGIVMWEVM 220 >4RC3-A nrPDB Length = 289 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 79/323 (24%), Positives = 133/323 (41%), Gaps = 66/323 (20%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP-----FDKPLFALRTLREIKIL 63 + S +Q+ LLG G +G V S VAIK +E + + R E+ +L Sbjct: 10 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 69 Query: 64 KHFKH--ENIITIFN-IQRPDSFENFNEVYIIQ--ELMQTDLHRVISTQMLSDDHIQYFI 118 K +I + + +RPDSF V I++ E +Q + L ++ + F Sbjct: 70 KKVSSGFSGVIRLLDWFERPDSF-----VLILERPEPVQDLFDFITERGALQEELARSFF 124 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSN-CDLKVCDFGLARIIDESAADNSEPTGQQS 177 +Q L AV+ H V+HRD+K N+LI+ N +LK+ DFG ++ ++ Sbjct: 125 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV----------- 173 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 T++ TR Y PE + + R+ VWS G +L + ++ G Sbjct: 174 -YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYD------------------MVCG 214 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 I H + E R + + + RV+ + L++ L P+ R Sbjct: 215 DIPFEHDE------EIIRGQVFFRQ--------------RVSSECQHLIRWCLALRPSDR 254 Query: 298 ITAKEALEHPYLQTYHDPNDEPE 320 T +E HP++Q P + E Sbjct: 255 PTFEEIQNHPWMQDVLLPQETAE 277 >5TUR-A nrPDB Length = 404 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 101/219 (46%), Gaps = 28/219 (12%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP-----FDKPLFALRTLREIKIL 63 + S +Q+ LLG G +G V S VAIK +E + + R E+ +L Sbjct: 125 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 184 Query: 64 KHFKH--ENIITIFN-IQRPDSFENFNEVYIIQ--ELMQTDLHRVISTQMLSDDHIQYFI 118 K +I + + +RPDSF V I++ E +Q + L ++ + F Sbjct: 185 KKVSSGFSGVIRLLDWFERPDSF-----VLILERPEPVQDLFDFITERGALQEELARSFF 239 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSN-CDLKVCDFGLARIIDESAADNSEPTGQQS 177 +Q L AV+ H V+HRD+K N+LI+ N +LK+ DFG ++ ++ Sbjct: 240 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV----------- 288 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 T++ TR Y PE + + R+ VWS G +L ++ Sbjct: 289 -YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDM 326 >3BGP-A nrPDB Length = 333 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 79/323 (24%), Positives = 133/323 (41%), Gaps = 66/323 (20%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP-----FDKPLFALRTLREIKIL 63 + S +Q+ LLG G +G V S VAIK +E + + R E+ +L Sbjct: 54 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 113 Query: 64 KHFKH--ENIITIFN-IQRPDSFENFNEVYIIQ--ELMQTDLHRVISTQMLSDDHIQYFI 118 K +I + + +RPDSF V I++ E +Q + L ++ + F Sbjct: 114 KKVSSGFSGVIRLLDWFERPDSF-----VLILERPEPVQDLFDFITERGALQEELARSFF 168 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSN-CDLKVCDFGLARIIDESAADNSEPTGQQS 177 +Q L AV+ H V+HRD+K N+LI+ N +LK+ DFG ++ ++ Sbjct: 169 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV----------- 217 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 T++ TR Y PE + + R+ VWS G +L + ++ G Sbjct: 218 -YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYD------------------MVCG 258 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 I H + E R + + + RV+ + L++ L P+ R Sbjct: 259 DIPFEHDE------EIIRGQVFFRQ--------------RVSSECQHLIRWCLALRPSDR 298 Query: 298 ITAKEALEHPYLQTYHDPNDEPE 320 T +E HP++Q P + E Sbjct: 299 PTFEEIQNHPWMQDVLLPQETAE 321 >2DQ7-X nrPDB Length = 283 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/225 (28%), Positives = 104/225 (46%), Gaps = 24/225 (10%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 QL LG G +G V T + VAIK ++P + L E +I+K KH+ ++ Sbjct: 11 LQLIKRLGNGQFGEVWMGTWNGNTK-VAIKTLKP--GTMSPESFLEEAQIMKKLKHDKLV 67 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQT----DLHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 ++ + + +YI+ E M D + + L ++ Q + + Sbjct: 68 QLYAVVSEEP------IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 121 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 N IHRDL+ +N+L+ + K+ DFGLAR+I +++E T +Q +W Sbjct: 122 ERMNYIHRDLRSANILVGNGLICKIADFGLARLI-----EDNEYTARQGAK---FPIKW- 172 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLR-RPIFPGRDYRHQL 232 APE L +++ DVWS G +L EL + R +PG + R L Sbjct: 173 TAPEAALY-GRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVL 216 >3ORP-A nrPDB Length = 311 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 104/221 (47%), Gaps = 11/221 (4%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK--KIEPFDKPLFALRTLREIKILKH 65 ++S ++L +LG G V A VA+K + + P F LR RE + Sbjct: 9 HLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAA 68 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-LSDDHIQYFIYQTLRA 124 H I+ +++ ++ +++ + L ++ T+ ++ I +A Sbjct: 69 LNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQA 128 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + H + +IHRD+KP+N++I++ +KV DFG+AR I AD+ Q + + + Sbjct: 129 LNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAI----ADSGNSVTQTAAV---IG 181 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG 225 T Y +PE + +R+ DV+S GC+L E+ P F G Sbjct: 182 TAQYLSPEQARGDSVDARS-DVYSLGCVLYEVLTGEPPFTG 221 >5X3F-B nrPDB Length = 393 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 60/214 (28%), Positives = 107/214 (50%), Gaps = 33/214 (15%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR----TLREIKILKHFKHENIITI 74 LG G++G V HK +G A+K ++ + + L+ TL E +IL + + Sbjct: 92 LGTGSFGRVMLVKHKESGNHYAMKILDK--QKVVKLKQIEHTLNEKRIL-----QAVNFP 144 Query: 75 FNIQRPDSFENFNEVYIIQEL-----MQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 F ++ SF++ + +Y++ E M + L R+ S+ H +++ Q + + LH Sbjct: 145 FLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRI---GRFSEPHARFYAAQIVLTFEYLH 201 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 ++I+RDLKP NLLI+ ++V DFG A+ + T G EY+ Sbjct: 202 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR-------TWTLCGTPEYL------ 248 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 APE++L+ Y++A+D W+ G ++ E+ P F Sbjct: 249 APEIILSKG-YNKAVDWWALGVLIYEMAAGYPPF 281 >2HW6-A nrPDB Length = 307 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 77/317 (24%), Positives = 134/317 (42%), Gaps = 41/317 (12%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 +Y ++S+ LLGEGAY V A G+ A+K IE R RE++ L Sbjct: 13 MYKLTSE-----LLGEGAYAKVQGAVSLQNGKEYAVKIIEK-QAGHSRSRVFREVETLYQ 66 Query: 66 FK-HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTL 122 + ++NI+ + FE+ Y++ E +Q L + + ++ + Sbjct: 67 CQGNKNILELIEF-----FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVA 121 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDF--GLARIIDESAADNSEPTGQQS 177 A+ LH + HRDLKP N+L S +K+CDF G ++ S + P Sbjct: 122 AALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPE---- 177 Query: 178 GMTEYVATRWYRAPEVMLT----SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLL 233 +T + Y APEV+ + Y + D+WS G +L + P F G Sbjct: 178 -LTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGH------- 229 Query: 234 LIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFD 293 G R ++ + +P +K + ++ + DL+ ++LV D Sbjct: 230 --CGADCGWDRGEVCRVCQNKLFESIQEGKYEFP----DKDWAHISSEAKDLISKLLVRD 283 Query: 294 PAKRITAKEALEHPYLQ 310 +R++A + L+HP++Q Sbjct: 284 AKQRLSAAQVLQHPWVQ 300 >6HV0-A nrPDB Length = 416 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 85/337 (25%), Positives = 146/337 (43%), Gaps = 64/337 (18%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILK 64 IV IS F K +LG GA G + + VA+K+I P F+ RE+++L+ Sbjct: 4 IVGKIS--FCPKDVLGHGAEGTIVYRGMFDNRD-VAVKRILP---ECFSFAD-REVQLLR 56 Query: 65 HF-KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQ--YFIYQT 121 +H N+I F ++ F+ YI EL L + + + ++ + QT Sbjct: 57 ESDEHPNVIRYFCTEKDRQFQ-----YIAIELCAATLQEYVEQKDFAHLGLEPITLLQQT 111 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLI---NSNCDLK--VCDFGLARIIDESAADNSEPTGQQ 176 + LH N++HRDLKP N+LI N++ +K + DFGL + + A ++ Sbjct: 112 TSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKL----AVGRHSFSRR 167 Query: 177 SGMTEYVATRWYRAPEVMLTSAKY--SRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLL 234 SG+ T + APE++ K + +D++S GC+ + G+ + Q + Sbjct: 168 SGVP---GTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANI 224 Query: 235 IFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDP 294 + G L C+ + + I +L+++M+ DP Sbjct: 225 LLGACS-------LDCLHPEKHEDVIAR---------------------ELIEKMIAMDP 256 Query: 295 AKRITAKEALEHPY-------LQTYHDPNDEPEGEPI 324 KR +AK L+HP+ LQ + D +D E E + Sbjct: 257 QKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESL 293 >4PL5-B nrPDB Length = 435 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 84/337 (24%), Positives = 148/337 (43%), Gaps = 64/337 (18%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILK 64 IV IS F K +LG GA G + + VA+K+I P F+ RE+++L+ Sbjct: 23 IVGKIS--FCPKDVLGHGAEGTIVYKGMFDNRD-VAVKRILP---ECFSFAD-REVQLLR 75 Query: 65 HF-KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQ--YFIYQT 121 +H N+I F ++ F+ YI EL L + + + ++ ++QT Sbjct: 76 ESDEHPNVIRYFCTEKDRQFQ-----YIAIELCAATLQEYVEQKDFAHLGLEPITLLHQT 130 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLI---NSNCDLK--VCDFGLARIIDESAADNSEPTGQQ 176 + LH N++HRDLKP N+L+ N++ +K + DFGL + + A ++ Sbjct: 131 TSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKL----AVGRHSFSRR 186 Query: 177 SGMTEYVATRWYRAPEVMLTSAKY--SRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLL 234 SG+ T + APE++ K + +D++S GC+ + G+ + Q + Sbjct: 187 SGVP---GTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANI 243 Query: 235 IFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDP 294 + G +L C S + + I +L+++M+ DP Sbjct: 244 LLGAC-------NLDCFHSDKHEDVIAR---------------------ELIEKMIAMDP 275 Query: 295 AKRITAKEALEHPY-------LQTYHDPNDEPEGEPI 324 +R +AK L+HP+ LQ + D +D E E + Sbjct: 276 QQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKEAL 312 >4C59-A nrPDB Length = 340 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 65/231 (28%), Positives = 111/231 (48%), Gaps = 27/231 (11%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI----EPFDKPLFALRTLREIKILKHFK- 67 +++ +L EG + V A +G A+K++ E ++ + ++E+ +K Sbjct: 29 LRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAI-----IQEVCFMKKLSG 83 Query: 68 HENII---TIFNIQRPDSFENFNEVYIIQELMQTDL----HRVISTQMLSDDHIQYFIYQ 120 H NI+ + +I + +S E ++ EL + L ++ S LS D + YQ Sbjct: 84 HPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQ 143 Query: 121 TLRAVKVLHGSN--VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 T RAV+ +H +IHRDLK NLL+++ +K+CDFG A I S + + Q+ Sbjct: 144 TCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTI--SHYPDYSWSAQRRA 201 Query: 179 MTEYVATR----WYRAPEVMLTSAKY--SRAMDVWSCGCILAELFLRRPIF 223 + E TR YR PE++ + + D+W+ GCIL L R+ F Sbjct: 202 LVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPF 252 >3OMV-A nrPDB Length = 307 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 69/287 (24%), Positives = 128/287 (44%), Gaps = 25/287 (8%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 +S+ L + +G G++G V + +K ++P + A R E+ +L+ +H Sbjct: 35 ASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRN--EVAVLRKTRHV 92 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYF--IYQTLRAVKV 127 NI+ D N + Q + L++ + Q Q QT + + Sbjct: 93 NILLFMGYMTKD-----NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDY 147 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 LH N+IHRD+K +N+ ++ +K+ DFGLA + +S S+ Q +G ++ Sbjct: 148 LHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQQVEQPTGSVLWM---- 201 Query: 188 YRAPEV--MLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 APEV M + +S DV+S G +L EL + + R Q++ ++G ++ Sbjct: 202 --APEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIF---MVGRGYAS 256 Query: 246 NDLRCI--ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRML 290 DL + P+A + + + + +FP++ I+LLQ L Sbjct: 257 PDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQI-LSSIELLQHSL 302 >5SYS-A nrPDB Length = 286 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 104/226 (46%), Gaps = 24/226 (10%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 +L+ LG+G +G T T VAIK ++P A L+E +++K +HE + Sbjct: 19 SLRLEVKLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMSPEAF--LQEAQVMKKLRHEKL 75 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQT----DLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 + ++ + + +YI+ E M D + + L + Q + Sbjct: 76 VQLYAVVSEEP------IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAY 129 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 + N +HRDL+ +N+L+ N KV DFGLAR+I +++E T +Q +W Sbjct: 130 VERMNYVHRDLRAANILVGENLVCKVADFGLARLI-----EDNEYTARQGAK---FPIKW 181 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLR-RPIFPGRDYRHQL 232 APE L +++ DVWS G +L EL + R +PG R L Sbjct: 182 -TAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL 225 >4CSV-A nrPDB Length = 275 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 61/220 (27%), Positives = 99/220 (45%), Gaps = 22/220 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 S+ L+ LG G +G V + VA+K ++ + + L+E +I+K KH N Sbjct: 11 SEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLK--EGTMSVEEFLQEAQIMKKLKHPN 68 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 ++ ++ + + +YII E M D R ++ + Q + Sbjct: 69 LVQLYGVCTKEP-----PIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMA 123 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L N IHRDL N L+ N +KV DFGLAR+I+E E T + + Sbjct: 124 YLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINE-----DEYTARAGAK---FPIK 175 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPI-FPG 225 W APE ++ ++S DVW+ G +L E+F + +PG Sbjct: 176 W-TAPEA-ISYNRFSIKSDVWAFGILLWEIFTYGQVPYPG 213 >4TNB-A nrPDB Length = 590 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 58/220 (26%), Positives = 102/220 (46%), Gaps = 23/220 (10%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP--FDKPLFALRTLREIKILKHFKHEN 70 F+ +LG+G +G VC+ + TG++ A K++E K L E +IL E Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQIL-----EK 240 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI---STQMLSDDHIQYFIYQTLRAVK 126 + + F + ++E + + ++ +M DL I ++ ++ + L ++ Sbjct: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH N ++RDLKP N+L++ +++ D GLA I E + V T Sbjct: 301 DLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL-----------IRGRVGTV 349 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGR 226 Y APEV L + +Y + D W GC++ E+ + F GR Sbjct: 350 GYMAPEV-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 >6CCF-A nrPDB Length = 290 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 55/233 (23%), Positives = 107/233 (45%), Gaps = 45/233 (19%) Query: 11 SDFQLKSLLGEGAYGVVCSATHK---------------------------PTGEIVAIKK 43 + ++L+S +G+GAYGVV A ++ P G A + Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA--Q 62 Query: 44 IEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHR 102 P + L R +EI ILK H N++ + + + +N +Y++ +L++ + Sbjct: 63 GGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDN---LYLVFDLLRKGPVME 119 Query: 103 VISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARII 162 V + S++ + ++ + ++ LH ++HRD+KPSNLL+ + +K+ DFG++ Sbjct: 120 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 179 Query: 163 DESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAK--YSRAMDVWSCGCIL 213 + G + ++ T + APE + S + +A+DVW+ G L Sbjct: 180 E----------GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTL 222 >4XEY-B nrPDB Length = 408 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 73/249 (29%), Positives = 109/249 (43%), Gaps = 45/249 (18%) Query: 2 PKR---IVYNIS----------SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD 48 PKR VY +S +D +K LG G YG V K VA+K ++ + Sbjct: 103 PKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK--E 160 Query: 49 KPLFALRTLREIKILKHFKHENIITIFNI-QRPDSFENFNEVYIIQELMQ----TDLHRV 103 + L+E ++K KH N++ + + R F YII E M D R Sbjct: 161 DTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPF------YIITEFMTYGNLLDYLRE 214 Query: 104 ISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIID 163 + Q ++ + Y Q A++ L N IHRDL N L+ N +KV DFGL+R++ Sbjct: 215 CNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM- 273 Query: 164 ESAADNSEPTGQQSGMTEYVATRW---YRAPEVMLTSAKYSRAMDVWSCGCILAEL--FL 218 TG T + ++ + APE L K+S DVW+ G +L E+ + Sbjct: 274 ---------TGDT--YTAHAGAKFPIKWTAPE-SLAYNKFSIKSDVWAFGVLLWEIATYG 321 Query: 219 RRPIFPGRD 227 P +PG D Sbjct: 322 MSP-YPGID 329 >1U5R-A nrPDB Length = 348 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 98/210 (46%), Gaps = 27/210 (12%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA--LRTLREIKILKHFKHENIITIFN 76 +G G++G V A E+VAIKK+ K ++E++ L+ +H N Sbjct: 62 IGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN-----T 116 Query: 77 IQRPDSFENFNEVYIIQELM---QTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNV 133 IQ + + +++ E +DL V + L + I + L+ + LH N+ Sbjct: 117 IQYRGCYLREHTAWLVMEYCLGSASDLLEV-HKKPLQEVEIAAVTHGALQGLAYLHSHNM 175 Query: 134 IHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV 193 IHRD+K N+L++ +K+ DFG A I+ A NS +V T ++ APEV Sbjct: 176 IHRDVKAGNILLSEPGLVKLGDFGSASIM---APANS-----------FVGTPYWMAPEV 221 Query: 194 MLT--SAKYSRAMDVWSCGCILAELFLRRP 221 +L +Y +DVWS G EL R+P Sbjct: 222 ILAMDEGQYDGKVDVWSLGITCIELAERKP 251 >3FXW-A nrPDB Length = 336 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 89/320 (27%), Positives = 140/320 (43%), Gaps = 61/320 (19%) Query: 2 PKRIVYNISSDFQL-KSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 PK+ Y ++ D+QL K +LG G G V H+ TG+ A+K + +D P + +E+ Sbjct: 21 PKK--YAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL--YDSP----KARQEV 72 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNE----VYIIQELMQT-DLHRVI---STQMLSDD 112 H++ I I D +EN + + II E M+ +L I Q ++ Sbjct: 73 D--HHWQASGGPHIVCIL--DVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTER 128 Query: 113 HIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADN 169 + A++ LH N+ HRD+KP NLL S + LK+ DFG A+ Sbjct: 129 EAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK--------- 179 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 E T Q+ + T +Y APEV L KY ++ D+WS G I+ L P Sbjct: 180 -ETT--QNALQTPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGFP-------- 227 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 P N + I SP + I+ L Y E + V+ L++ + Sbjct: 228 ------------PFYSNTGQAI-SPGMKRRIR-LGQYGFPNPE--WSEVSEDAKQLIRLL 271 Query: 290 LVFDPAKRITAKEALEHPYL 309 L DP +R+T + + HP++ Sbjct: 272 LKTDPTERLTITQFMNHPWI 291 >6NPU-A nrPDB Length = 298 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 102/227 (44%), Gaps = 32/227 (14%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +D +K LG G YG V K VA+K ++ + + L+E ++K KH N Sbjct: 26 TDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK--EDTMEVEEFLKEAAVMKEIKHPN 83 Query: 71 IITIFNI-QRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQYFIYQTLRAV 125 ++ + + R F YII E M D R + Q ++ + Y Q A+ Sbjct: 84 LVQLLGVCTREPPF------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 137 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 + L N IHRDL N L+ N +KV DFGL+R++ TG T + Sbjct: 138 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM----------TGDT--YTAHAGA 185 Query: 186 RW---YRAPEVMLTSAKYSRAMDVWSCGCILAEL--FLRRPIFPGRD 227 ++ + APE L K+S DVW+ G +L E+ + P +PG D Sbjct: 186 KFPIKWTAPES-LAYNKFSIKSDVWAFGVLLWEIATYGMSP-YPGID 230 >1K9A-A nrPDB Length = 450 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 97/210 (46%), Gaps = 27/210 (12%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 + +L +G+G +G V ++ G VA+K I+ A L E ++ +H N+ Sbjct: 194 ELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK---NDATAQAFLAEASVMTQLRHSNL 248 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 + + + E +YI+ E M D R +L D + F A++ Sbjct: 249 VQLLGV----IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 L G+N +HRDL N+L++ + KV DFGL + A +++ TG+ + +W Sbjct: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGK-------LPVKW 352 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 APE L K+S DVWS G +L E++ Sbjct: 353 -TAPEA-LREKKFSTKSDVWSFGILLWEIY 380 >6E9W-A nrPDB Length = 443 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 51/217 (23%), Positives = 102/217 (47%), Gaps = 24/217 (11%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 + D+++ ++G GA+G V HK T ++ A+K + F+ ++ ++ Sbjct: 101 AEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFE-------MIKRSDSAFFWEER 153 Query: 70 NIITIFN----IQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDHIQYFIYQTLRA 124 +I+ N +Q +F++ +Y++ E M DL ++S + + +++ + + A Sbjct: 154 DIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLA 213 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + +H IHRD+KP N+L++ + LK+ DFG +++ + V Sbjct: 214 LDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTA---------VG 264 Query: 185 TRWYRAPEVMLTSAK---YSRAMDVWSCGCILAELFL 218 T Y +PEV+ + Y R D WS G L E+ + Sbjct: 265 TPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLV 301 >1BYG-A nrPDB Length = 278 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 97/210 (46%), Gaps = 27/210 (12%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 + +L +G+G +G V ++ G VA+K I+ A L E ++ +H N+ Sbjct: 22 ELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK---NDATAQAFLAEASVMTQLRHSNL 76 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 + + + E +YI+ E M D R +L D + F A++ Sbjct: 77 VQLLGV----IVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 132 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 L G+N +HRDL N+L++ + KV DFGL + A +++ TG+ + +W Sbjct: 133 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGK-------LPVKW 180 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 APE L K+S DVWS G +L E++ Sbjct: 181 -TAPEA-LREKKFSTKSDVWSFGILLWEIY 208 >2GCD-A nrPDB Length = 309 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 98/210 (46%), Gaps = 27/210 (12%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA--LRTLREIKILKHFKHENIITIFN 76 +G G++G V A E+VAIKK+ K ++E++ L+ +H N Sbjct: 23 IGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN-----T 77 Query: 77 IQRPDSFENFNEVYIIQELM---QTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNV 133 IQ + + +++ E +DL V + L + I + L+ + LH N+ Sbjct: 78 IQYRGCYLREHTAWLVMEYCLGSASDLLEV-HKKPLQEVEIAAVTHGALQGLAYLHSHNM 136 Query: 134 IHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV 193 IHRD+K N+L++ +K+ DFG A I+ A NS +V T ++ APEV Sbjct: 137 IHRDVKAGNILLSEPGLVKLGDFGSASIM---APANS-----------FVGTPYWMAPEV 182 Query: 194 MLT--SAKYSRAMDVWSCGCILAELFLRRP 221 +L +Y +DVWS G EL R+P Sbjct: 183 ILAMDEGQYDGKVDVWSLGITCIELAERKP 212 >2A27-A nrPDB Length = 321 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 79/302 (26%), Positives = 122/302 (40%), Gaps = 56/302 (18%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFD-----KPLFALRTLREIKILKHFKHENIIT 73 LG G + +V K TG A K I+ + + RE+ IL+ H N+IT Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 74 IFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGS 131 + D +EN +V +I EL+ + + LS++ FI Q L V LH Sbjct: 80 LH-----DVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTK 134 Query: 132 NVIHRDLKPSN-LLINSNC---DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 + H DLKP N +L++ N +K+ DFGLA I++ T Sbjct: 135 KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-----------FKNIFGTPE 183 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 + APE++ D+WS G I L F G D + + L I D D Sbjct: 184 FVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLG-DTKQETL---ANITAVSYDFD 238 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 E+ F + + D ++++LV + KR+T +EAL HP Sbjct: 239 ------------------------EEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHP 274 Query: 308 YL 309 ++ Sbjct: 275 WI 276 >1ZWS-A nrPDB Length = 288 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 79/302 (26%), Positives = 122/302 (40%), Gaps = 56/302 (18%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFD-----KPLFALRTLREIKILKHFKHENIIT 73 LG G + +V K TG A K I+ + + RE+ IL+ H N+IT Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 74 IFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGS 131 + D +EN +V +I EL+ + + LS++ FI Q L V LH Sbjct: 80 LH-----DVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTK 134 Query: 132 NVIHRDLKPSN-LLINSNC---DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 + H DLKP N +L++ N +K+ DFGLA I++ T Sbjct: 135 KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-----------FKNIFGTPE 183 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 + APE++ D+WS G I L F G D + + L I + D D Sbjct: 184 FVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLG-DTKQETL---ANITSVSYDFD 238 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 E+ F + D ++++LV + KR+T +EAL HP Sbjct: 239 ------------------------EEFFSHTSELAKDFIRKLLVKETRKRLTIQEALRHP 274 Query: 308 YL 309 ++ Sbjct: 275 WI 276 >6CKI-A nrPDB Length = 316 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 84/328 (25%), Positives = 141/328 (42%), Gaps = 45/328 (13%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 VY + D +LGEGA+ V + + T + A+K IE + + R RE+++L Sbjct: 13 VYQLQED-----VLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRS-RVFREVEMLYQ 66 Query: 66 FK-HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTL 122 + H N++ + FE + Y++ E M+ L + + ++ + Sbjct: 67 CQGHRNVLELIE-----FFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVA 121 Query: 123 RAVKVLHGSNVIHRDLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 A+ LH + HRDLKP N+L N +K+CDFGL I + + P + Sbjct: 122 SALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNG--DCSPISTPELL 179 Query: 180 TEYVATRWYRAPEVMLT----SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLI 235 T + Y APEV+ ++ Y + D+WS G IL L P F GR Sbjct: 180 TP-CGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGR--------C 230 Query: 236 FGIIGTPHSDNDLRC----IESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLV 291 G + C ES + +Y +P +K + ++ DL+ ++LV Sbjct: 231 GSDCGWDRGEACPACQNMLFESIQEGKY-----EFP----DKDWAHISCAAKDLISKLLV 281 Query: 292 FDPAKRITAKEALEHPYLQTYHDPNDEP 319 D +R++A + L+HP++Q N P Sbjct: 282 RDAKQRLSAAQVLQHPWVQGCAPENTLP 309 >2YAB-A nrPDB Length = 361 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 80/302 (26%), Positives = 122/302 (40%), Gaps = 56/302 (18%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFD-----KPLFALRTLREIKILKHFKHENIIT 73 LG G + +V K TG A K I+ + + RE+ IL+ H NIIT Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIIT 79 Query: 74 IFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGS 131 + D +EN +V +I EL+ + + LS++ FI Q L V LH Sbjct: 80 LH-----DVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTK 134 Query: 132 NVIHRDLKPSN-LLINSNC---DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 + H DLKP N +L++ N +K+ DFGLA I++ T Sbjct: 135 KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-----------FKNIFGTPE 183 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 + APE++ D+WS G I L F G D + + L I D D Sbjct: 184 FVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLG-DTKQETL---ANITAVSYDFD 238 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 E+ F + + D ++++LV + KR+T +EAL HP Sbjct: 239 ------------------------EEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHP 274 Query: 308 YL 309 ++ Sbjct: 275 WI 276 >6GQK-A nrPDB Length = 328 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 66/233 (28%), Positives = 98/233 (42%), Gaps = 41/233 (17%) Query: 19 LGEGAYGVVCSATHKP-----TGEIVAIKKIEPFDKPLFALRTLREIKILKHF-KHENII 72 LG GA+G V AT + VA+K ++P + E+K+L + HENI+ Sbjct: 49 LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHENIV 108 Query: 73 TIFNIQRPDS-------------FENF----NEVYIIQELMQTDLHRVISTQMLSDDHIQ 115 + NF + ++ ++ DL++ L+ +H+ Sbjct: 109 NLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYK----DFLTLEHLL 164 Query: 116 YFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARII--DESAADNSEPT 173 F YQ + + L N IHRDL N+L+ K+CDFGLAR I D + D Sbjct: 165 SFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDKGNAR 224 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFPG 225 + +W APE + S Y+ DVWS G L ELF L +PG Sbjct: 225 ---------LPVKW-MAPESIFNSV-YTFESDVWSYGIFLWELFSLGSSPYPG 266 >2FO0-A nrPDB Length = 495 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 72/249 (28%), Positives = 109/249 (43%), Gaps = 45/249 (18%) Query: 2 PKR---IVYNIS----------SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD 48 PKR VY +S +D +K LG G YG V K VA+K ++ + Sbjct: 195 PKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK--E 252 Query: 49 KPLFALRTLREIKILKHFKHENIITIFNI-QRPDSFENFNEVYIIQELMQ----TDLHRV 103 + L+E ++K KH N++ + + R F YII E M D R Sbjct: 253 DTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPF------YIITEFMTYGNLLDYLRE 306 Query: 104 ISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIID 163 + Q ++ + Y Q A++ L N IHR+L N L+ N +KV DFGL+R++ Sbjct: 307 CNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLM- 365 Query: 164 ESAADNSEPTGQQSGMTEYVATRW---YRAPEVMLTSAKYSRAMDVWSCGCILAEL--FL 218 TG T + ++ + APE L K+S DVW+ G +L E+ + Sbjct: 366 ---------TGDT--YTAHAGAKFPIKWTAPE-SLAYNKFSIKSDVWAFGVLLWEIATYG 413 Query: 219 RRPIFPGRD 227 P +PG D Sbjct: 414 MSP-YPGID 421 >4FR4-A nrPDB Length = 384 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 53/219 (24%), Positives = 111/219 (50%), Gaps = 29/219 (13%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRT-----LREIKILKHFK 67 F++ +G+G++G VC T ++ A+K + +K R +E++I++ + Sbjct: 17 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYM---NKQKCVERNEVRNVFKELQIMQGLE 73 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-LSDDHIQYFIYQTLRAV 125 H ++ ++ SF++ +++++ +L+ DL + + ++ ++ FI + + A+ Sbjct: 74 HPFLVNLWY-----SFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMAL 128 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 L +IHRD+KP N+L++ + + + DF +A ++ +++ +T T Sbjct: 129 DYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAML-----------PRETQITTMAGT 177 Query: 186 RWYRAPEVMLT--SAKYSRAMDVWSCGCILAELFL-RRP 221 + Y APE+ + A YS A+D WS G EL RRP Sbjct: 178 KPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRP 216 >1FOT-A nrPDB Length = 318 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 111/218 (50%), Gaps = 37/218 (16%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKI-LKHFKHE 69 DFQ+ LG G++G V + G A+K ++ +EI + LK +H Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLK------------KEIVVRLKQVEHT 53 Query: 70 N----IITI----FNIQRPDSFENFNEVYIIQELMQT-DLHRVI-STQMLSDDHIQYFIY 119 N +++I F I+ +F++ ++++I + ++ +L ++ +Q + +++ Sbjct: 54 NDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAA 113 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 + A++ LH ++I+RDLKP N+L++ N +K+ DFG A+ + + T G Sbjct: 114 EVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYV-------PDVTYTLCGT 166 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 +Y+ APEV+ T Y++++D WS G ++ E+ Sbjct: 167 PDYI------APEVVSTKP-YNKSIDWWSFGILIYEML 197 >4PDO-A nrPDB Length = 299 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 65/221 (29%), Positives = 104/221 (47%), Gaps = 30/221 (13%) Query: 16 KSLLGEGAYGVVCSATHKPTG---EI-VAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 + ++G G +G V K + E+ VAIK ++ + L E I+ F H NI Sbjct: 39 QKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNI 98 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ---TLRAV--- 125 I + + + + II E M+ + L + ++ + Q LR + Sbjct: 99 IRLEGV-----ISKYKPMMIITEYMENGAL----DKFLREKDGEFSVLQLVGMLRGIAAG 149 Query: 126 -KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 K L N +HRDL N+L+NSN KV DFGL+R+++ D+ E T SG + Sbjct: 150 MKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLE----DDPEATYTTSGGK--IP 203 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL--FLRRPIF 223 RW APE ++ K++ A DVWS G ++ E+ + RP + Sbjct: 204 IRW-TAPEA-ISYRKFTSASDVWSFGIVMWEVMTYGERPYW 242 >5GRN-A nrPDB Length = 356 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 68/247 (27%), Positives = 107/247 (43%), Gaps = 51/247 (20%) Query: 15 LKSLLGEGAYGVVCSAT------HKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK- 67 L +LG GA+G V T +P + VA+K ++P + + E+KI+ H Sbjct: 50 LGRVLGSGAFGKVVEGTAYGLSRSQPVMK-VAVKMLKPTARSSEKQALMSELKIMTHLGP 108 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQEL-----MQTDLHRVIST---------------Q 107 H NI+ + + +YII E + LH+ + Sbjct: 109 HLNIVNLLG-----ACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKN 163 Query: 108 MLSDDHIQ--------YFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLA 159 +LSDD+ + F YQ R ++ L N +HRDL N+L+ +K+CDFGLA Sbjct: 164 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA 223 Query: 160 RIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-L 218 R D + S + ++ +W APE + + Y+ DVWS G +L E+F L Sbjct: 224 R-------DIMHDSNYVSKGSTFLPVKW-MAPESIFDNL-YTTLSDVWSYGILLWEIFSL 274 Query: 219 RRPIFPG 225 +PG Sbjct: 275 GGTPYPG 281 >2R2P-A nrPDB Length = 295 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 66/226 (29%), Positives = 104/226 (46%), Gaps = 29/226 (12%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEI---VAIKKIEPFDKPLFALRTLREIKILKHF 66 +S ++ ++G G +G VCS K G+ VAIK ++ L E I+ F Sbjct: 21 ASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQF 80 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ---TLR 123 H NII + + V I+ E M+ + T + +D Q+ + Q LR Sbjct: 81 DHPNIIHLEGV-----VTKSKPVMIVTEYMENG---SLDTFLKKNDG-QFTVIQLVGMLR 131 Query: 124 AV----KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 + K L +HRDL N+LINSN KV DFGL+R++++ +P + Sbjct: 132 GISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLED------DPEAAYTTR 185 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL--FLRRPIF 223 + RW APE + K++ A DVWS G ++ E+ + RP + Sbjct: 186 GGKIPIRW-TAPEA-IAFRKFTSASDVWSYGIVMWEVVSYGERPYW 229 >5B2L-A nrPDB Length = 324 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 62/215 (28%), Positives = 98/215 (45%), Gaps = 26/215 (12%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKI-LKHFKHE 69 +D + +G G G V + TG ++A+K++ R L ++ + LK Sbjct: 17 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 76 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRV-------ISTQMLSDDHIQYFIYQTL 122 I+ F +F +V+I ELM T ++ I ++L + I + L Sbjct: 77 YIVQCFG-----TFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILG--KMTVAIVKAL 129 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLA-RIIDESAADNSEPTGQQSGMTE 181 +K HG VIHRD+KPSN+L++ +K+CDFG++ R++D A S +G Sbjct: 130 YYLKEKHG--VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS------AGCAA 181 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 Y+A P+ T Y DVWS G L EL Sbjct: 182 YMAPERIDPPDP--TKPDYDIRADVWSLGISLVEL 214 >4AF3-A nrPDB Length = 292 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 76/305 (24%), Positives = 132/305 (43%), Gaps = 56/305 (18%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKHE 69 DF++ LG+G +G V A K + IVA+K + +K + REI+I H H Sbjct: 24 DFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHP 83 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDHIQYFIYQTLR-AVKV 127 NI+ ++N F + +Y+I E + +L++ + D+ I + L A+ Sbjct: 84 NILRLYNY-----FYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMY 138 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 HG VIHRD+KP NLL+ +LK+ DFG + P+ ++ M T Sbjct: 139 CHGKKVIHRDIKPENLLLGLKGELKIADFGWS---------VHAPSLRRKTM---CGTLD 186 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y PE M+ ++ +D+W G + EL + P F H++ Sbjct: 187 YLPPE-MIEGRMHNEKVDLWCIGVLCYELLVGNPPFE---------------SASHNETY 230 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFDPAKRITAKEALEH 306 R ++ ++ FP P G DL+ ++L +P++R+ + H Sbjct: 231 RRIVK------------------VDLKFPASVPTGAQDLISKLLRHNPSERLPLAQVSAH 272 Query: 307 PYLQT 311 P+++ Sbjct: 273 PWVRA 277 >3DTC-A nrPDB Length = 271 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 70/231 (30%), Positives = 104/231 (45%), Gaps = 33/231 (14%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLR-EIKILKHFK 67 ++ L+ ++G G +G V A G+ VA+K +P + + +R E K+ K Sbjct: 7 AELTLEEIIGIGGFGKVYRAFW--IGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLK 64 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 H NII + R + N +++ L+RV+S + + D + + Q R + Sbjct: 65 HPNIIAL----RGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNY 120 Query: 128 LHGSNV---IHRDLKPSNLLI--------NSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 LH + IHRDLK SN+LI SN LK+ DFGLAR T + Sbjct: 121 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR--------EWHRTTKM 172 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 S Y + APEV+ S +S+ DVWS G +L EL F G D Sbjct: 173 SAAGAYA----WMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGID 218 >4UY9-A nrPDB Length = 323 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 70/231 (30%), Positives = 104/231 (45%), Gaps = 33/231 (14%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLR-EIKILKHFK 67 ++ L+ ++G G +G V A G+ VA+K +P + + +R E K+ K Sbjct: 9 AELTLEEIIGIGGFGKVYRAFW--IGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLK 66 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 H NII + R + N +++ L+RV+S + + D + + Q R + Sbjct: 67 HPNIIAL----RGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNY 122 Query: 128 LHGSNV---IHRDLKPSNLLI--------NSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 LH + IHRDLK SN+LI SN LK+ DFGLAR T + Sbjct: 123 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR--------EWHRTTKM 174 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 S Y + APEV+ S +S+ DVWS G +L EL F G D Sbjct: 175 SAAGTYA----WMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGID 220 >6DBN-A nrPDB Length = 316 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 76/298 (25%), Positives = 123/298 (41%), Gaps = 42/298 (14%) Query: 19 LGEGAYGVVCSATHKP----TGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITI 74 LGEG +G V + P TGE VA+K ++P +EI+IL++ HENI+ Sbjct: 43 LGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKY 102 Query: 75 FNIQRPDSFENFNEVY------IIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 I D + ++E + + +++ Q L + Q + + L Sbjct: 103 KGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLK------YAVQICKGMDYL 156 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 +HRDL N+L+ S +K+ DFGL + I+ + + S WY Sbjct: 157 GSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDS------PVFWY 210 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 APE ++ S K+ A DVWS G L EL + D + L +IG H + Sbjct: 211 -APECLMQS-KFYIASDVWSFGVTLHELL----TYCDSD-SSPMALFLKMIGPTHGQMTV 263 Query: 249 -RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 R + + + K LP P P E L+++ F P+ R + + +E Sbjct: 264 TRLVNTLKEG---KRLPCPPNCPDEVY---------QLMRKCWEFQPSNRTSFQNLIE 309 >4QMW-A nrPDB Length = 310 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 72/282 (25%), Positives = 124/282 (43%), Gaps = 30/282 (10%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +G+G++G V T ++VAIK I+ + +EI +L + + Sbjct: 37 IGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYG-- 94 Query: 79 RPDSFENFNEVYIIQE-LMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 S+ +++II E L ++ L + I + + L+ + LH IHRD Sbjct: 95 ---SYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRD 151 Query: 138 LKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTS 197 +K +N+L++ + ++K+ DFG+A + T Q +V T ++ APEV+ S Sbjct: 152 IKAANVLLSEHGEVKLADFGVA----------GQLTDTQIKRNTFVGTPFWMAPEVIKQS 201 Query: 198 AKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAR 257 A S+A D+WS G EL P P + H + ++F I N+ +E Sbjct: 202 AYDSKA-DIWSLGITAIELARGEP--PHSEL-HPMKVLFLI-----PKNNPPTLEG---- 248 Query: 258 EYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 Y K L + A L K P P +LL+ + AK+ + Sbjct: 249 NYSKPLKEFVEACLNKE-PSFRPTAKELLKHKFILRNAKKTS 289 >2PMN-X nrPDB Length = 348 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 70/265 (26%), Positives = 116/265 (43%), Gaps = 45/265 (16%) Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDH----- 113 E++I+ K+E +T I N++EVYII E M+ D D Sbjct: 93 ELQIITDIKNEYCLTCEGI-----ITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCF 147 Query: 114 -----IQYFIYQTLRAVKVLHG-SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAA 167 I+ I L + +H N+ HRD+KPSN+L++ N +K+ DFG + + + Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKI 207 Query: 168 DNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRA-MDVWSCGCILAELFLRRPIFPGR 226 S T + + PE + Y+ A +D+WS G L +F F Sbjct: 208 KGSRGTYE------------FMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFS-- 253 Query: 227 DYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR--VNPKGID 284 + L+ +F I T + IE P R + +YP + ++ + ID Sbjct: 254 -LKISLVELFNNIRTKN-------IEYPLDRNHF----LYPLTNKKSTCSNNFLSNEDID 301 Query: 285 LLQRMLVFDPAKRITAKEALEHPYL 309 L+ L +PA+RIT+++AL+H +L Sbjct: 302 FLKLFLRKNPAERITSEDALKHEWL 326 >3NYO-A nrPDB Length = 576 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 74/309 (23%), Positives = 134/309 (43%), Gaps = 56/309 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA--LRTLREIKILKHFKHEN 70 F+ +LG+G +G VC+ + TG++ A KK+E L E +IL E Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL-----EK 240 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI---STQMLSDDHIQYFIYQTLRAVK 126 + + F + ++E + + ++ LM DL I + ++ + ++ Sbjct: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH +++RDLKP N+L++ + +++ D GLA + P GQ + V T Sbjct: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV---------PEGQT--IKGRVGTV 349 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APEV + + +Y+ + D W+ GC+L E+ + F R + Sbjct: 350 GYMAPEV-VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKK----------------- 391 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI-----TAK 301 I+ +K +P E+ R +P+ L ++L DPA+R+ +A+ Sbjct: 392 ----IKREEVERLVKEVP-------EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAR 440 Query: 302 EALEHPYLQ 310 E EHP + Sbjct: 441 EVKEHPLFK 449 >3LLT-A nrPDB Length = 360 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 76/336 (22%), Positives = 138/336 (41%), Gaps = 62/336 (18%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +G+G +G V H + A+K + K + + E ILK ++++I ++ Sbjct: 43 MGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKI--EADILKKIQNDDINNNNIVK 100 Query: 79 RPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQ---YFIYQTLRAVKVLHGSNVIH 135 F ++ + +I E + L+ +I+ + HI+ + + L+A+ L ++ H Sbjct: 101 YHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTH 160 Query: 136 RDLKPSNLLIN-------------------------SNCDLKVCDFGLARIIDESAADNS 170 DLKP N+L++ + +K+ DFG A Sbjct: 161 TDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCA----------- 209 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 T + + TR YRAPEV+L + + D+WS GC+LAEL+ +F ++ Sbjct: 210 --TFKSDYHGSIINTRQYRAPEVILNLG-WDVSSDMWSFGCVLAELYTGSLLFRTHEHME 266 Query: 231 QLLLIFGII---------------GTPHSDNDLRCIESPRAREYIKSLP-MYPAAPLEKM 274 L ++ II G+ + + D + P I S+ + PL K+ Sbjct: 267 HLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKI 326 Query: 275 FPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 + D L +L DP R + E L+H +L+ Sbjct: 327 IK--HELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >2Y6O-A nrPDB Length = 291 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 61/218 (27%), Positives = 99/218 (45%), Gaps = 27/218 (12%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGE---IVAIKKIEPFDKPLFALRTLREIKILKHF 66 +S +++ ++G G +G VCS K G+ VAIK ++ L E I+ F Sbjct: 13 ASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQF 72 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ---TLR 123 H NII + + V II E M+ L + ++ + Q LR Sbjct: 73 DHPNIIHLEGV-----VTKCKPVMIITEYMENGSL----DAFLRKNDGRFTVIQLVGMLR 123 Query: 124 AV----KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 + K L + +HRDL N+L+NSN KV DFG++R++++ +P + Sbjct: 124 GIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLED------DPEAAYTTR 177 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 + RW APE + K++ A DVWS G ++ E+ Sbjct: 178 GGKIPIRW-TAPEA-IAYRKFTSASDVWSYGIVMWEVM 213 >5EG3-A nrPDB Length = 334 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 68/236 (28%), Positives = 101/236 (42%), Gaps = 45/236 (19%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-------------EIKILKH 65 LGEGA+G V A E V I K +P + A++ L+ E++++K Sbjct: 43 LGEGAFGQVVMA------EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM 96 Query: 66 F-KHENIITIFNIQRPD----------SFENFNEVYIIQE----LMQTDLHRVISTQMLS 110 KH+NII + D S N E + + D++RV QM Sbjct: 97 IGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMTF 156 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 D + YQ R ++ L IHRDL N+L+ N +K+ DFGLAR I+ Sbjct: 157 KDLVS-CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFKE 215 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFPG 225 G+ + +W APE + Y+ DVWS G ++ E+F L +PG Sbjct: 216 TTNGR-------LPVKWM-APEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYPG 262 >4FZF-B nrPDB Length = 283 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 73/292 (25%), Positives = 124/292 (42%), Gaps = 48/292 (16%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +G+G++G V T ++VAIK I+ + +EI +L + + Sbjct: 16 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYG-- 73 Query: 79 RPDSFENFNEVYIIQE-LMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 S+ ++++II E L ++ + I + + L+ + LH IHRD Sbjct: 74 ---SYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 130 Query: 138 LKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTS 197 +K +N+L++ D+K+ FG+A + T Q +V T ++ APEV+ S Sbjct: 131 IKAANVLLSEQGDVKLAAFGVA----------GQLTDTQIKRNTFVGTPFWMAPEVIQQS 180 Query: 198 AKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAR 257 A S+A D+WS G EL P P D H + ++F I P ++ Sbjct: 181 AYDSKA-DIWSLGITAIELAKGEP--PNSDM-HPMRVLFLI---PKNN------PPTLVG 227 Query: 258 EYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 ++ KS + A L K DP+ R TAKE L+H ++ Sbjct: 228 DFTKSFKEFIDACLNK-------------------DPSFRPTAKELLKHKFI 260 >3DKO-A nrPDB Length = 318 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 65/239 (27%), Positives = 105/239 (43%), Gaps = 34/239 (14%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHKPTGE---IVAIKKIEPFDKPLFA 53 P R V+ + + +++ ++G G +G VCS K G+ VAIK ++ Sbjct: 29 PNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQR 88 Query: 54 LRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDH 113 L E I+ F H N++ + + V I+ E M+ L Sbjct: 89 RDFLCEASIMGQFDHPNVVHLEGV-----VTRGKPVMIVIEFMENGA----LDAFLRKHD 139 Query: 114 IQYFIYQ---TLRAV----KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESA 166 Q+ + Q LR + + L +HRDL N+L+NSN KV DFGL+R+I++ Sbjct: 140 GQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDP 199 Query: 167 ADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL--FLRRPIF 223 TG + + RW APE + K++ A DVWS G ++ E+ + RP + Sbjct: 200 EAVYTTTGGK------IPVRW-TAPEA-IQYRKFTSASDVWSYGIVMWEVMSYGERPYW 250 >4NEU-A nrPDB Length = 333 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 58/256 (22%), Positives = 112/256 (43%), Gaps = 19/256 (7%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 M ++ SSDF + L G +G V H+ G ++ + + L E Sbjct: 14 MSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEA 73 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQ-YFIY 119 K++ +H ++ + + E +++ + + +L V+ +M + ++ I Sbjct: 74 KMMNRLRHSRVVKLLGV----IIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL 129 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSE-------- 171 + + + LHG VIH+DLKP N+L++++ +K+ D GLA S +N E Sbjct: 130 EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD 189 Query: 172 PTGQQSGMTEYVATRWYRAPEVML-TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 T +++G T +Y APE + +AK + DV+S +L +F + + Sbjct: 190 GTAKKNG-----GTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQ 244 Query: 231 QLLLIFGIIGTPHSDN 246 QL++ P D+ Sbjct: 245 QLIMCIKSGNRPDVDD 260 >2PSQ-A nrPDB Length = 370 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 67/241 (27%), Positives = 100/241 (41%), Gaps = 55/241 (22%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-------------EIKILKH 65 LGEG +G V A E V I K +P + A++ L+ E++++K Sbjct: 89 LGEGCFGQVVMA------EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM 142 Query: 66 F-KHENIITIFNIQRPDSFENFNEVYIIQELMQT-------------------DLHRVIS 105 KH+NII + D +Y+I E D++RV Sbjct: 143 IGKHKNIINLLGACTQDG-----PLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 197 Query: 106 TQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDES 165 QM D + YQ R ++ L IHRDL N+L+ N +K+ DFGLAR I+ Sbjct: 198 EQMTFKDLVS-CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI 256 Query: 166 AADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFP 224 G+ + +W APE + Y+ DVWS G ++ E+F L +P Sbjct: 257 DYYKKTTNGR-------LPVKWM-APEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYP 307 Query: 225 G 225 G Sbjct: 308 G 308 >4OTD-A nrPDB Length = 341 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 59/224 (26%), Positives = 107/224 (47%), Gaps = 26/224 (11%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-------KPLFALRTLREIKILK 64 DF+ ++LG G +G V + +P+GE+ AIK ++ D + L + R + + Sbjct: 13 DFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK--RILAAVT 70 Query: 65 HFKHENIITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLR 123 H ++ +F Q P+ + ++++ DL I + + S+ ++ + Sbjct: 71 SAGHPFLVNLFGCFQTPE-----HVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVL 125 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 ++ LH +++RDLK NLL+++ +K+ DFGL + E G + + Sbjct: 126 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCK----------EGMGYGDRTSTFC 175 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 T + APEV LT Y+RA+D W G +L E+ + FPG D Sbjct: 176 GTPEFLAPEV-LTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDD 218 >5UUU-A nrPDB Length = 547 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 102/212 (48%), Gaps = 20/212 (9%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +DF + ++G G +G V TG++ A+K + DK ++ + + + Sbjct: 198 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL---DKKRIKMKQGETLALNERIMLSL 254 Query: 71 IITI---FNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQ-MLSDDHIQYFIYQTLRAV 125 + T F + +F +++ I +LM DLH +S + S+ ++++ + + + Sbjct: 255 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 314 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 + +H V++RDLKP+N+L++ + +++ D GL A D S+ S V T Sbjct: 315 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGL-------ACDFSKKKPHAS-----VGT 362 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 Y APEV+ Y + D +S GC+L +L Sbjct: 363 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL 394 >4E20-A nrPDB Length = 290 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 94/211 (44%), Gaps = 30/211 (14%) Query: 19 LGEGAYGVVCSATHKPT----GEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITI 74 LGEG +G V + PT GE+VA+K ++ P REI+IL+ HE+I+ Sbjct: 16 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVK- 74 Query: 75 FNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVI 134 + D E ++ +++ + L + + + F Q + LH + I Sbjct: 75 YKGCCEDQGEKSVQL-VMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQHYI 133 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR-------- 186 HR L N+L++++ +K+ DFGLA+ + P G EY R Sbjct: 134 HRALAARNVLLDNDRLVKIGDFGLAKAV---------PEGH-----EYYRVREDGDSPVF 179 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 WY APE L K+ A DVWS G L EL Sbjct: 180 WY-APEC-LKECKFYYASDVWSFGVTLYELL 208 >3PVW-A nrPDB Length = 695 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 102/212 (48%), Gaps = 20/212 (9%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +DF + ++G G +G V TG++ A+K + DK ++ + + + Sbjct: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCL---DKKRIKMKQGETLALNERIMLSL 245 Query: 71 IITI---FNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQ-MLSDDHIQYFIYQTLRAV 125 + T F + +F +++ I +LM DLH +S + S+ ++++ + + + Sbjct: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGL 305 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 + +H V++RDLKP+N+L++ + +++ D GL A D S+ S V T Sbjct: 306 EHMHNRFVVYRDLKPANILLDEHGHVRISDLGL-------ACDFSKKKPHAS-----VGT 353 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 Y APEV+ Y + D +S GC+L +L Sbjct: 354 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLL 385 >3DLS-A nrPDB Length = 335 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/225 (27%), Positives = 98/225 (43%), Gaps = 28/225 (12%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP--------FDKPLFALRTLREIK 61 S + S LG GA+G V +A K + V +K I+ + P TL EI Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTL-EIA 81 Query: 62 ILKHFKHENIITIFNIQRPDSFEN--FNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIY 119 IL +H NII + +I FEN F ++ + + DL I D+ + +I+ Sbjct: 82 ILSRVEHANIIKVLDI-----FENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIF 136 Query: 120 -QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 Q + AV L ++IHRD+K N++I + +K+ DFG A ++ Sbjct: 137 RQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKL----------- 185 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 + T Y APEV++ + +++WS G L L F Sbjct: 186 FYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPF 230 >6J5U-C nrPDB Length = 426 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/228 (25%), Positives = 106/228 (46%), Gaps = 30/228 (13%) Query: 8 NISSDFQLKSLLGEGAYGVV---------CSATHKPTGEIVAIKKIEPFDKPLFALRTLR 58 N + +F+ +LLGEG +G V +A+ +G +VA+K+++P + L Sbjct: 81 NATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKP-EGFQGHKEWLT 139 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI---STQMLSDDHIQ 115 E+ L H N++ + E N + + + + + L + Q L+ Sbjct: 140 EVNYLGQLSHPNLVLLVGY----CAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRM 195 Query: 116 YFIYQTLRAVKVLH--GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPT 173 + + LH S VI+RD K +N+L++++ + K+ DFGLA+ + PT Sbjct: 196 KVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAK---------AGPT 246 Query: 174 GQQSGM-TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRR 220 G + + T+ + T Y APE + T + + DV+S G +L EL R Sbjct: 247 GDNTHVSTKVIGTHGYAAPEYVAT-GRLTAKSDVYSFGVVLLELISGR 293 >6DBM-A nrPDB Length = 318 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 89/211 (42%), Gaps = 30/211 (14%) Query: 19 LGEGAYGVVCSATHKPT----GEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITI 74 LGEG +G V + PT GE+VA+K ++ P +EI IL+ HE+II Sbjct: 39 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYHEHIIKY 98 Query: 75 FNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVI 134 + +++ + L + + + F Q + LH + I Sbjct: 99 KGCCEDAGAASLQ--LVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQHYI 156 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR-------- 186 HRDL N+L++++ +K+ DFGLA+ + E EY R Sbjct: 157 HRDLAARNVLLDNDRLVKIGDFGLAKAVPEG--------------HEYYRVREDGDSPVF 202 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 WY APE L K+ A DVWS G L EL Sbjct: 203 WY-APEC-LKEYKFYYASDVWSFGVTLYELL 231 >3KA0-A nrPDB Length = 320 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 85/317 (26%), Positives = 138/317 (43%), Gaps = 66/317 (20%) Query: 9 ISSDFQLKS-LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 I D+++ S +LG G G V +K T E A+K ++ D P + RE+++ H++ Sbjct: 13 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--DCP----KARREVEL--HWR 64 Query: 68 HENIITIFNIQRPDSFENFNE-----VYIIQELMQTDLHRVI---STQMLSDDHIQYFIY 119 I I D +EN + +++ L +L I Q ++ + Sbjct: 65 ASQCPHIVRI--VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 122 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQ 176 A++ LH N+ HRD+KP NLL S N LK+ DFG A+ E+ + NS Sbjct: 123 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNS------ 173 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 +TE T +Y APEV L KY ++ D+WS G I+ L P F Y + L I Sbjct: 174 --LTEPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPF----YSNHGLAI- 225 Query: 237 GIIGTPHSDNDLRCIE----SPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 +P +R + +P E + + M L++ +L Sbjct: 226 ----SPGMKTRIRMGQYEFPNPEWSEVSEEVKM-------------------LIRNLLKT 262 Query: 293 DPAKRITAKEALEHPYL 309 +P +R+T E + HP++ Sbjct: 263 EPTQRMTITEFMNHPWI 279 >4P5Q-A nrPDB Length = 361 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/226 (28%), Positives = 100/226 (44%), Gaps = 29/226 (12%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHK--PTGEI-VAIKKIEPFDKPLFALRTLREIKILKHF 66 +++ + ++G G +G VCS K EI VAIK ++ L E I+ F Sbjct: 32 ATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQF 91 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ---TLR 123 H NII + + V I+ E M+ L Q+ + Q LR Sbjct: 92 DHPNIIRLEGV-----VTKSKPVMIVTEYMENGSL----DSFLRKHDAQFTVIQLVGMLR 142 Query: 124 AV----KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 + K L +HRDL N+LINSN KV DFGL+R++++ +P + Sbjct: 143 GIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLED------DPEAAYTTR 196 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL--FLRRPIF 223 + RW +PE + K++ A DVWS G +L E+ + RP + Sbjct: 197 GGKIPIRW-TSPEA-IAYRKFTSASDVWSYGIVLWEVMSYGERPYW 240 >4TPT-A nrPDB Length = 303 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 92/209 (44%), Gaps = 15/209 (7%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +LG+G +G THK TG+++ +K++ D+ L E+K+++ H N++ + Sbjct: 7 VLGKGFFGQAIKVTHKATGKVMVMKELIRCDEET-QKTFLTEVKVMRSLDHPNVLKFIGV 65 Query: 78 QRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 D N YI ++ L S F + LH +IHRD Sbjct: 66 LYKDKKLNLLTEYIEGGTLKDFLR---SMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRD 122 Query: 138 LKPSNLLINSNCDLKVCDFGLARIIDE--SAADNSEPTGQQSGMTE--------YVATRW 187 L N LI + + V DFGL+R+I E A + T ++ + + V + Sbjct: 123 LNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPY 182 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 + APE ML Y +D++S G +L E+ Sbjct: 183 WMAPE-MLNGKSYDETVDIFSFGIVLCEI 210 >6BDL-A nrPDB Length = 347 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/229 (25%), Positives = 102/229 (44%), Gaps = 36/229 (15%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKIL-----KH 65 SDF + LG G +G V E+V +K E FA++ L++ I+ +H Sbjct: 34 SDFNIIDTLGVGGFGRV---------ELVQLKSEE---SKTFAMKILKKRHIVDTRQQEH 81 Query: 66 FKHENII-----TIFNIQRPDSFENFNEVYIIQE-LMQTDLHRVISTQ-MLSDDHIQYFI 118 + E I + F ++ +F++ +Y++ E + +L ++ + D +++ Sbjct: 82 IRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYT 141 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 + A LH +I+RDLKP NL+++ K+ DFG A+ I G Sbjct: 142 ACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKI-----------GFGKK 190 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 + T Y APE++L + + D WS G ++ EL P F G D Sbjct: 191 TWTFCGTPEYVAPEIILNKG-HDISADYWSLGILMYELLTGSPPFSGPD 238 >5O0Y-A nrPDB Length = 579 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 72/264 (27%), Positives = 118/264 (44%), Gaps = 47/264 (17%) Query: 58 REIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYF 117 RE +I K H I+ +++ D+ ++F V E D + + +++S+ + Sbjct: 337 REYRIHKELDHPRIVKLYDYFSLDT-DSFCTVLEYCEGNDLDFY-LKQHKLMSEKEARSI 394 Query: 118 IYQTLRAVKVLHGSN--VIHRDLKPSN-LLINSNC--DLKVCDFGLARIIDE---SAADN 169 I Q + A+K L+ +IH DLKP N LL+N ++K+ DFGL++I+D+ ++ D Sbjct: 395 IMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDG 454 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTSA---KYSRAMDVWSCGCILAE-LFLRRPIFPG 225 E T Q +G T WY PE + K S +DVWS G I + L+ R+P G Sbjct: 455 MELTSQGAG------TYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF--G 506 Query: 226 RDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDL 285 + Q +L I L+ E +P P+ V P+ Sbjct: 507 HNQSQQDILQENTI--------LKATEV-----------QFPPKPV------VTPEAKAF 541 Query: 286 LQRMLVFDPAKRITAKEALEHPYL 309 ++R L + RI ++ PYL Sbjct: 542 IRRCLAYRKEDRIDVQQLACDPYL 565 >2HK5-A nrPDB Length = 270 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 106/219 (48%), Gaps = 26/219 (11%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +L+ LG G +G V AT+ + VA+K ++P + A L E ++K +H+ ++ Sbjct: 17 LKLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMSVEAF--LAEANVMKTLQHDKLV 73 Query: 73 TIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDHIQYFI---YQTLRAVKVL 128 + + + +YII E M + L + + S + I Q + + Sbjct: 74 KLHAVVTKEP------IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFI 127 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 N IHRDL+ +N+L++++ K+ DFGLAR+I +++E T ++ +W Sbjct: 128 EQRNYIHRDLRAANILVSASLVCKIADFGLARVI-----EDNEYTAREGAK---FPIKW- 178 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAEL--FLRRPIFPG 225 APE + ++ DVWS G +L E+ + R P +PG Sbjct: 179 TAPEA-INFGSFTIKSDVWSFGILLMEIVTYGRIP-YPG 215 >4HVI-A nrPDB Length = 314 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 58/211 (27%), Positives = 99/211 (46%), Gaps = 25/211 (11%) Query: 17 SLLGEGAYGVVCSATHKP----TGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 S LG+G +G V + P TG +VA+K+++ P REI+ILK + I+ Sbjct: 16 SQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HSGPDQQRDFQREIQILKALHSDFIV 74 Query: 73 TIFNIQRPDSFENFNEVY------IIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 + ++ V +++ +Q R+ ++++L + Q + ++ Sbjct: 75 KYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLL------LYSSQICKGME 128 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L +HRDL N+L+ S +K+ DFGLA+++ D ++ G + Sbjct: 129 YLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLL---PLDKDYYVVREPGQSPIF--- 182 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 WY APE L+ +SR DVWS G +L ELF Sbjct: 183 WY-APES-LSDNIFSRQSDVWSFGVVLYELF 211 >2XYN-A nrPDB Length = 292 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 62/226 (27%), Positives = 100/226 (44%), Gaps = 30/226 (13%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +D +K LG G YG V K VA+K ++ + + L+E ++K KH N Sbjct: 32 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK--EDTMEVEEFLKEAAVMKEIKHPN 89 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM----QTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 ++ + + + YI+ E M D R + + ++ + Y Q A++ Sbjct: 90 LVQLLGVCTLEP-----PFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAME 144 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L N IHRDL N L+ N +KV DFGL+R++ TG T + + Sbjct: 145 YLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM----------TGDT--YTAHAGAK 192 Query: 187 W---YRAPEVMLTSAKYSRAMDVWSCGCILAEL--FLRRPIFPGRD 227 + + APE L +S DVW+ G +L E+ + P +PG D Sbjct: 193 FPIKWTAPES-LAYNTFSIKSDVWAFGVLLWEIATYGMSP-YPGID 236 >4CRS-A nrPDB Length = 341 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 59/233 (25%), Positives = 106/233 (45%), Gaps = 27/233 (11%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--------EPFDKPLFAL 54 +R +N+ DF+ ++L G +G V A +K T E+ AIK + + D + Sbjct: 5 QRFQFNLQ-DFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEK 63 Query: 55 RTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHI 114 R + ++H N+ F + + ++++ DL I T + S+ Sbjct: 64 RIFETVNSVRHPFLVNLFACFQTKE-------HVCFVMEYAAGGDLMMHIHTDVFSEPRA 116 Query: 115 QYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTG 174 ++ + ++ LH +++RDLK NLL+++ +K+ DFGL + E G Sbjct: 117 VFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCK----------EGMG 166 Query: 175 QQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 + + T + APEV LT Y+RA+D W G ++ E+ + FPG D Sbjct: 167 YGDRTSTFCGTPEFLAPEV-LTETSYTRAVDWWGLGVLIYEMLVGESPFPGDD 218 >4LQP-A nrPDB Length = 508 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 66/278 (23%), Positives = 115/278 (41%), Gaps = 67/278 (24%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIK---KIEPFDKPLFALRTLREIKILKHFKH 68 DF ++G+GA+G V K TG+I A+K K E + K A E +L Sbjct: 103 DFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLA-HVKAERDVLAGSDS 161 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 +++++ SF++ +Y+I E + + +I Q+ ++D ++++ + + A++ Sbjct: 162 PWVVSLYY-----SFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIE 216 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLA-------------RIIDESAADN--SE 171 +H IHR +KP N+LI+ +K+ DFGL+ +++ + A N S+ Sbjct: 217 TIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISK 276 Query: 172 PTGQQSGMTEYVATR--------------------W----------------YRAPEVML 195 P + T+ R W Y APE+ L Sbjct: 277 PGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFL 336 Query: 196 TSAKYSRAMDVWSCGCILAELFLRRPIF----PGRDYR 229 Y + D WS G I+ E + P F P YR Sbjct: 337 YQG-YGQECDWWSLGAIMYECLIGWPPFCSETPQETYR 373 >3BEA-A nrPDB Length = 333 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 67/244 (27%), Positives = 106/244 (43%), Gaps = 43/244 (17%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHKPTGE-----IVAIKKIEPFDKPL 51 P ++ YN +F Q LG GA+G V AT G+ VA+K ++ Sbjct: 32 PTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD 91 Query: 52 FALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQE---------------- 94 + E+KI+ H +HENI+ + + + V +I E Sbjct: 92 EKEALMSELKIMSHLGQHENIVNLLG-----ACTHGGPVLVITEYCCYGDLLNFLRRKSR 146 Query: 95 LMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVC 154 +++TD I+ LS + +F Q + + L N IHRD+ N+L+ + K+ Sbjct: 147 VLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIG 206 Query: 155 DFGLAR-IIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCIL 213 DFGLAR I+++S N G + +W APE + Y+ DVWS G +L Sbjct: 207 DFGLARDIMNDS---NYIVKGNAR-----LPVKW-MAPESIFDCV-YTVQSDVWSYGILL 256 Query: 214 AELF 217 E+F Sbjct: 257 WEIF 260 >5VD3-A nrPDB Length = 311 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 95/219 (43%), Gaps = 22/219 (10%) Query: 2 PKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKK-IEPFDKPLFALRTLREI 60 P R FQ S LG G+YG V K G + A+K+ + PF P R L E+ Sbjct: 48 PSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEV 107 Query: 61 KILKHFKHENIIT-IFNIQRPDSFENFNEVYIIQELMQTDL--HRVISTQMLSDDHIQYF 117 HE + ++ ++E +Y+ EL L H L + + + Sbjct: 108 G-----SHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGY 162 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 + TL A+ LH ++H D+KP+N+ + K+ DFGL +++ A E Q Sbjct: 163 LRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGL--LVELGTAGAGE---VQE 217 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 G Y+ APE++ S Y A DV+S G + E+ Sbjct: 218 GDPRYM------APELLQGS--YGTAADVFSLGLTILEV 248 >4OLI-A nrPDB Length = 645 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 90/211 (42%), Gaps = 30/211 (14%) Query: 19 LGEGAYGVVCSATHKPT----GEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITI 74 LGEG +G V + PT GE+VA+K ++ P +EI IL+ HE+II Sbjct: 361 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKY 420 Query: 75 FNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVI 134 ++ +++ + L + + + F Q + LH + I Sbjct: 421 KGCCEDQGEKSLQ--LVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQHYI 478 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR-------- 186 HR+L N+L++++ +K+ DFGLA+ + E EY R Sbjct: 479 HRNLAARNVLLDNDRLVKIGDFGLAKAVPEGH--------------EYYRVREDGDSPVF 524 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 WY APE L K+ A DVWS G L EL Sbjct: 525 WY-APEC-LKEYKFYYASDVWSFGVTLYELL 553 >4RA4-A nrPDB Length = 355 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/223 (24%), Positives = 101/223 (45%), Gaps = 23/223 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK--KIEPFDKPLFALRTLREIKILKHFKH 68 +DF +LG+G++G V A K T E+ AIK K + + T+ E ++L Sbjct: 20 TDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDK 79 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 +T Q F+ + +Y + E + ++ + + ++ + + Sbjct: 80 PPFLT----QLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 135 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT--EYVA 184 LH +I+RDLK N++++S +K+ DFG+ + E D G+T + Sbjct: 136 FLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCK---EHMMD---------GVTTRTFCG 183 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 T Y APE+ + Y +++D W+ G +L E+ +P F G D Sbjct: 184 TPDYIAPEI-IAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGED 225 >2OZA-A nrPDB Length = 356 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 84/317 (26%), Positives = 137/317 (43%), Gaps = 66/317 (20%) Query: 9 ISSDFQLKS-LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 I D+++ S +LG G G V +K T E A+K ++ D P + RE+++ H++ Sbjct: 15 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--DCP----KARREVEL--HWR 66 Query: 68 HENIITIFNIQRPDSFENFNE-----VYIIQELMQTDLHRVI---STQMLSDDHIQYFIY 119 I I D +EN + +++ L +L I Q ++ + Sbjct: 67 ASQCPHIVRI--VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 124 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQ 176 A++ LH N+ HRD+KP NLL S N LK+ DFG A+ E+ + NS Sbjct: 125 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNS------ 175 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 +T T +Y APEV L KY ++ D+WS G I+ L P F Y + L I Sbjct: 176 --LTTPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPF----YSNHGLAI- 227 Query: 237 GIIGTPHSDNDLRCIE----SPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 +P +R + +P E + + M L++ +L Sbjct: 228 ----SPGMKTRIRMGQYEFPNPEWSEVSEEVKM-------------------LIRNLLKT 264 Query: 293 DPAKRITAKEALEHPYL 309 +P +R+T E + HP++ Sbjct: 265 EPTQRMTITEFMNHPWI 281 >4F9B-A nrPDB Length = 361 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 90/361 (24%), Positives = 149/361 (41%), Gaps = 75/361 (20%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHK-PTG--EIVAIKKIEPFDKPLFALRTLREIKI 62 V +S+ F+++ +GEG + V AT + G E +A+K + P P+ R E++ Sbjct: 16 VPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPI---RIAAELQC 72 Query: 63 LK-HFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQT 121 L +N++ + R + Y+ E L+ LS ++ ++ Sbjct: 73 LTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNS------LSFQEVREYMLNL 126 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNC-DLKVCDFGLARIIDESAAD-----NSEPTGQ 175 +A+K +H ++HRD+KPSN L N + DFGLA+ ++ + SE + Sbjct: 127 FKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQE 186 Query: 176 QSGMT---------EYVATR----WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRR-P 221 + + VA R +RAPEV+ + A+D+WS G I L R P Sbjct: 187 RCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYP 246 Query: 222 IFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSL---PMYPAAPLEKMFPRV 278 + D L I I G+ + I++ A+ + KS+ PA L K+ R+ Sbjct: 247 FYKASDDLTALAQIMTIRGSRET------IQA--AKTFGKSILCSKEVPAQDLRKLCERL 298 Query: 279 NPKGIDLLQRMLVFD-----------------------------PAKRITAKEALEHPYL 309 +G+D L D PA RITA+EAL HP+ Sbjct: 299 --RGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFF 356 Query: 310 Q 310 + Sbjct: 357 K 357 >1NY3-A nrPDB Length = 400 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 84/317 (26%), Positives = 137/317 (43%), Gaps = 66/317 (20%) Query: 9 ISSDFQLKS-LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 I D+++ S +LG G G V +K T E A+K ++ D P + RE+++ H++ Sbjct: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--DCP----KARREVEL--HWR 110 Query: 68 HENIITIFNIQRPDSFENFNE-----VYIIQELMQTDLHRVI---STQMLSDDHIQYFIY 119 I I D +EN + +++ L +L I Q ++ + Sbjct: 111 ASQCPHIVRI--VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQ 176 A++ LH N+ HRD+KP NLL S N LK+ DFG A+ E+ + NS Sbjct: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNS------ 219 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 +T T +Y APEV L KY ++ D+WS G I+ L P F Y + L I Sbjct: 220 --LTTPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPF----YSNHGLAI- 271 Query: 237 GIIGTPHSDNDLRCIE----SPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 +P +R + +P E + + M L++ +L Sbjct: 272 ----SPGMKTRIRMGQYEFPNPEWSEVSEEVKM-------------------LIRNLLKT 308 Query: 293 DPAKRITAKEALEHPYL 309 +P +R+T E + HP++ Sbjct: 309 EPTQRMTITEFMNHPWI 325 >3KUL-B nrPDB Length = 325 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/218 (27%), Positives = 96/218 (44%), Gaps = 27/218 (12%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEI---VAIKKIEPFDKPLFALRTLREIKILKHF 66 +S ++ ++G G G VC + G+ VAIK ++ L E I+ F Sbjct: 48 ASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQF 107 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ---TLR 123 H NII + + I+ E M+ + T + + D Q+ I Q LR Sbjct: 108 DHPNIIRLEGVVTRGRL-----AMIVTEYMENG---SLDTFLRTHDG-QFTIMQLVGMLR 158 Query: 124 AV----KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 V + L +HRDL N+L++SN KV DFGL+R++++ TG + Sbjct: 159 GVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGK--- 215 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 + RW APE + +S A DVWS G ++ E+ Sbjct: 216 ---IPIRWT-APEA-IAFRTFSSASDVWSFGVVMWEVL 248 >5X5O-A nrPDB Length = 310 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/218 (27%), Positives = 92/218 (42%), Gaps = 28/218 (12%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 D Q G G++G V A + VA+KK+ L+ +E +IL H NI Sbjct: 16 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL---------LKIEKEAEILSVLSHRNI 66 Query: 72 ITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHG 130 I + I P ++ E + L D ++ + DHI + + + LH Sbjct: 67 IQFYGVILEPPNYGIVTEYASLGSLY--DYINSNRSEEMDMDHIMTWATDVAKGMHYLHM 124 Query: 131 S---NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 VIHRDLK N++I ++ LK+CDFG +R + + V T Sbjct: 125 EAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTT------------HMSLVGTFP 172 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG 225 + APEV + S S D +S G +L E+ R F G Sbjct: 173 WMAPEV-IQSLPVSETCDTYSYGVVLWEMLTREVPFKG 209 >4UYA-A nrPDB Length = 340 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 64/231 (27%), Positives = 102/231 (44%), Gaps = 37/231 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE---PFDKPLFALRTLREIKILKHFKHE 69 +LK L+G G +G V AT + G+ VA+K D A RE ++ +H Sbjct: 28 LELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHP 85 Query: 70 NIITIFNI--QRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NII + + Q+P + +++ L+R ++ + + + + Q R + Sbjct: 86 NIIELRGVCLQQP------HLCLVLEFARGGALNRALAGRRIPPHVLVNWAVQIARGMLY 139 Query: 128 LHGSN---VIHRDLKPSNLLINS--------NCDLKVCDFGLARIIDESAADNSEPTGQQ 176 LH ++HRDLK SN+L+ N LK+ DFGLAR + Sbjct: 140 LHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRT----------- 188 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 + M A W APEV + S+ +S+ D+WS G +L EL + G D Sbjct: 189 TKMATAGAYAWM-APEV-IKSSLFSKGSDIWSYGVLLWELLTGEVPYRGID 237 >5LPV-A nrPDB Length = 296 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 62/226 (27%), Positives = 105/226 (46%), Gaps = 34/226 (15%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI----EPFDKPLFALRTLREIKILKH 65 ++ F SL+G G +G V A K G VAIKK+ D+ A E++ + Sbjct: 16 TNGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDREFMA-----EMETIGK 69 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYFIYQTL-- 122 KH N++ + + +E ++ E M+ L V+ + + + + + Sbjct: 70 IKHRNLVPLLGYCKVG-----DERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAI 124 Query: 123 ---RAVKVLHGS---NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 R + LH + ++IHRD+K SN+L++ N + +V DFG+AR++ SA D Sbjct: 125 GSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLM--SAMDTHLSVSTL 182 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRP 221 +G YV +Y+ S + S DV+S G +L EL +RP Sbjct: 183 AGTPGYVPPEYYQ-------SFRCSTKGDVYSYGVVLLELLTGKRP 221 >5LPZ-A nrPDB Length = 332 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 62/226 (27%), Positives = 105/226 (46%), Gaps = 34/226 (15%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI----EPFDKPLFALRTLREIKILKH 65 ++ F SL+G G +G V A K G VAIKK+ D+ A E++ + Sbjct: 16 TNGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDREFMA-----EMETIGK 69 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYFIYQTL-- 122 KH N++ + + +E ++ E M+ L V+ + + + + + Sbjct: 70 IKHRNLVPLLGYCKVG-----DERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAI 124 Query: 123 ---RAVKVLHGS---NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 R + LH + ++IHRD+K SN+L++ N + +V DFG+AR++ SA D Sbjct: 125 GSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLM--SAMDTHLSVSTL 182 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRP 221 +G YV +Y+ S + S DV+S G +L EL +RP Sbjct: 183 AGTPGYVPPEYYQ-------SFRCSTKGDVYSYGVVLLELLTGKRP 221 >4XI2-A nrPDB Length = 446 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/212 (26%), Positives = 93/212 (43%), Gaps = 41/212 (19%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNI- 77 LG G +GVV + + VAIK I + + + E K++ + HE ++ ++ + Sbjct: 195 LGTGQFGVVKYGKWRGQYD-VAIKMIR--EGSMSEDEFIEEAKVMMNLSHEKLVQLYGVC 251 Query: 78 --QRPDSFENFNEVYIIQELMQTDL---------HRVISTQMLSDDHIQYFIYQTLRAVK 126 QRP ++II E M HR + Q+L A++ Sbjct: 252 TKQRP--------IFIITEYMANGCLLNYLREMRHRFQTQQLLE------MCKDVCEAME 297 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLAR-IIDESAADNSEPTGQQSGMTEYVAT 185 L +HRDL N L+N +KV DFGL+R ++D+ S + Sbjct: 298 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYT---------SSVGSKFPV 348 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 RW PEV++ S K+S D+W+ G ++ E++ Sbjct: 349 RW-SPPEVLMYS-KFSSKSDIWAFGVLMWEIY 378 >2PL0-A nrPDB Length = 289 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 100/220 (45%), Gaps = 28/220 (12%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +L LG G +G V + + VA+K ++ A L E ++K +H+ ++ Sbjct: 25 LKLVERLGAGQFGEVWMGYYNGHTK-VAVKSLKQGSMSPDAF--LAEANLMKQLQHQRLV 81 Query: 73 TIFNI--QRPDSFENFNEVYIIQELMQT----DLHRVISTQMLSDDHIQYFIYQTLRAVK 126 ++ + Q P +YII E M+ D + S L+ + + Q + Sbjct: 82 RLYAVVTQEP--------IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 133 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 + N IHRDL+ +N+L++ K+ DFGLAR+I +++E T ++ + Sbjct: 134 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-----EDNEYTAREGAK---FPIK 185 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPI-FPG 225 W APE + ++ DVWS G +L E+ I +PG Sbjct: 186 W-TAPEA-INYGTFTIKSDVWSFGILLTEIVTHGRIPYPG 223 >4Y93-A nrPDB Length = 446 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 95/211 (45%), Gaps = 39/211 (18%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNI- 77 LG G +GVV + + VAIK I+ + + + E K++ + HE ++ ++ + Sbjct: 196 LGTGQFGVVKYGKWRGQYD-VAIKMIK--EGSMSEDEFIEEAKVMMNLSHEKLVQLYGVC 252 Query: 78 --QRPDSFENFNEVYIIQELMQTDL---------HRVISTQMLSDDHIQYFIYQTLRAVK 126 QRP ++II E M HR + Q+L A++ Sbjct: 253 TKQRP--------IFIITEYMANGCLLNYLREMRHRFQTQQLLE------MCKDVCEAME 298 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L +HRDL N L+N +KV DFG+ R + + +S TG + + Sbjct: 299 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSS--TGSK------FPVK 350 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 W +PEV++ S K+S D+W+ G ++ E++ Sbjct: 351 W-ASPEVLMYS-KFSSKSDIWAFGVLMWEIY 379 >6E4F-A nrPDB Length = 290 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 56/212 (26%), Positives = 94/212 (44%), Gaps = 41/212 (19%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNI- 77 LG G +GVV + + VAIK I+ + + + E K++ + HE ++ ++ + Sbjct: 39 LGTGQFGVVKYGKWRGQYD-VAIKMIK--EGSMSEDEFIEEAKVMMNLSHEKLVQLYGVC 95 Query: 78 --QRPDSFENFNEVYIIQELMQTDL---------HRVISTQMLSDDHIQYFIYQTLRAVK 126 QRP ++II E M HR + Q+L A++ Sbjct: 96 TKQRP--------IFIITEYMANGCLLNYLREMRHRFQTQQLLE------MCKDVCEAME 141 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLAR-IIDESAADNSEPTGQQSGMTEYVAT 185 L +HRDL N L+N +KV DFGL+R ++D+ S + Sbjct: 142 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYT---------SSVGSKFPV 192 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 RW PEV++ S K+S D+W+ G ++ E++ Sbjct: 193 RW-SPPEVLMYS-KFSSKSDIWAFGVLMWEIY 222 >5XD6-A nrPDB Length = 305 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 62/232 (26%), Positives = 105/232 (45%), Gaps = 22/232 (9%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 +P + +I+ ++ KSL+GEG+YG V K +G+ AIKK++ +P L ++ Sbjct: 12 IPADELRDITDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQP--DQEFLAQV 68 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLH---RVISTQ---MLSDDHI 114 ++ + EN++ + Y + LH V Q +LS Sbjct: 69 SMVSRLRQENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQR 128 Query: 115 QYFIYQTLRAVKVLH---GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSE 171 R ++ LH +VIHRD+K SN+L+ + K+ DF L+ + AA Sbjct: 129 VKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAA---- 184 Query: 172 PTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPI 222 + T + T Y APE +T +++ DV+S G +L EL R+P+ Sbjct: 185 ----RLHSTRVLGTFGYHAPEYAMTGTLSTKS-DVYSFGVVLLELLTGRKPV 231 >5TQX-A nrPDB Length = 655 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 51/219 (23%), Positives = 93/219 (42%), Gaps = 24/219 (10%) Query: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 + ++++ LG G +G VC H+ +AIK R EI+I+K Sbjct: 4 FGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKL 63 Query: 67 KHENIITIFNIQRPDSFENFNE---VYIIQELMQTDLHRVIS----TQMLSDDHIQYFIY 119 H N++ ++ P+ + ++ DL ++++ L + I + Sbjct: 64 NHANVVKACDV--PEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLS 121 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLL---INSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 ++ LH + +IHRDLKP N++ + K+ D G A+ +D+ Sbjct: 122 DIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGEL--------- 172 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAE 215 TE+V T Y APE + + Y+ +D WS G ++ E Sbjct: 173 --CTEFVGTLQYLAPE-LFENKPYTATVDYWSFGTMVFE 208 >2X4F-A nrPDB Length = 373 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 75/304 (24%), Positives = 129/304 (42%), Gaps = 59/304 (19%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPF---DKPLFALRTLREIKILKHFKHENIITI 74 +LG G +G V TG +A K I+ DK EI ++ H N+I + Sbjct: 96 ILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKE----EVKNEISVMNQLDHANLIQL 151 Query: 75 FNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQM-LSDDHIQYFIYQTLRAVKVLHGS 131 + D+FE+ N++ ++ E + R+I L++ F+ Q ++ +H Sbjct: 152 Y-----DAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQM 206 Query: 132 NVIHRDLKPSNLL-INSNC-DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 ++H DLKP N+L +N + +K+ DFGLAR +P + + T + Sbjct: 207 YILHLDLKPENILCVNRDAKQIKIIDFGLAR--------RYKP---REKLKVNFGTPEFL 255 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLR 249 APEV + S D+WS G I L F G DND Sbjct: 256 APEV-VNYDFVSFPTDMWSVGVIAYMLLSGLSPFLG-------------------DNDAE 295 Query: 250 CIESPRAREYIKSLPMYPAAPLE-KMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 + + A + LE + F ++ + + + ++L+ + + RI+A EAL+HP+ Sbjct: 296 TLNNILACRW----------DLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPW 345 Query: 309 LQTY 312 L + Sbjct: 346 LSDH 349 >3A4O-X nrPDB Length = 286 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 56/218 (25%), Positives = 101/218 (46%), Gaps = 23/218 (10%) Query: 14 QLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIIT 73 +L LG G +G V + + + VA+K ++P + A L E ++K +H+ ++ Sbjct: 16 KLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMSVQAF--LEEANLMKTLQHDKLVR 72 Query: 74 IFNIQRPDSFENFNEVYIIQELMQT----DLHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 ++ + + +YII E M D + + + F Q + + Sbjct: 73 LYAVVTRE-----EPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIE 127 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 N IHRDL+ +N+L++ + K+ DFGLAR+I +++E T ++ +W Sbjct: 128 RKNYIHRDLRAANVLVSESLMCKIADFGLARVI-----EDNEYTAREGAK---FPIKW-T 178 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPI-FPGR 226 APE + ++ DVWS G +L E+ I +PGR Sbjct: 179 APEA-INFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR 215 >5LOH-A nrPDB Length = 341 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 42/144 (29%), Positives = 74/144 (51%), Gaps = 7/144 (4%) Query: 82 SFENFNEVYIIQE-LMQTDLHRVISTQMLSDDHIQY-FIYQTLRAVKVLHGSNVIHRDLK 139 S ++ N VY++ E L+ D+ ++ D+ + +I + A+ LH +IHRDLK Sbjct: 102 SLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLK 161 Query: 140 PSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAK 199 P N+LI++ +K+ DFGL+++ + + ++ + T Y APE++L A Sbjct: 162 PDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRT----FCGTPDYLAPELLLGRA- 216 Query: 200 YSRAMDVWSCGCILAELFLRRPIF 223 + A+D W+ G L E P F Sbjct: 217 HGPAVDWWALGVCLFEFLTGIPPF 240 >3TKU-A nrPDB Length = 433 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 55/235 (23%), Positives = 110/235 (46%), Gaps = 23/235 (9%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD----KPLFALRTLREIKILKHFK 67 DF++ ++G GA+G V K T I A+K + ++ R R++ + + Sbjct: 91 DFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQ 150 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQEL-MQTDLHRVIST--QMLSDDHIQYFIYQTLRA 124 IT + +F++ N +Y++ + + DL ++S L +D +++I + + A Sbjct: 151 ---WITALHY----AFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLA 203 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + +H + +HRD+KP N+L++ N +++ DFG +++ D + + G +Y++ Sbjct: 204 IDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMND---DGTVQSSVAVGTPDYIS 260 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 +A E + KY D WS G + E+ F Y L+ +G I Sbjct: 261 PEILQAMEDGM--GKYGPECDWWSLGVCMYEMLYGETPF----YAESLVETYGKI 309 >2A1A-B nrPDB Length = 284 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 56/230 (24%), Positives = 101/230 (43%), Gaps = 50/230 (21%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 DF+ L+G G +G V A H+ G+ IK+++ ++ + RE+K L H NI Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNE-----KAEREVKALAKLDHVNI 66 Query: 72 ITI------FNIQRPDSFENFNE-----VYI-------------IQELMQTDLHRVISTQ 107 + F+ S +N + ++I I++ L +V++ + Sbjct: 67 VHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALE 126 Query: 108 MLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAA 167 + Q + V +H +I+RDLKPSN+ + +K+ DFGL ++ Sbjct: 127 LFE---------QITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLV-----TSL 172 Query: 168 DNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 N + G Y+ +PE ++S Y + +D+++ G ILAEL Sbjct: 173 KNDGKRTRSKGTLRYM------SPE-QISSQDYGKEVDLYALGLILAELL 215 >4IDT-A nrPDB Length = 356 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 93/203 (45%), Gaps = 22/203 (10%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 LG G++G V K TG A+KK+ L R E+ I+ ++ Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVR-----LEVFRA-EELMACAGLTSPRIVPLYGAV 135 Query: 79 RPDSFENFNEVYIIQELMQT-DLHRVISTQ-MLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 R + N I EL++ L +++ Q L +D Y++ Q L ++ LH ++H Sbjct: 136 REGPWVN-----IFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHG 190 Query: 137 DLKPSNLLINSNCD-LKVCDFGLARIIDESAADNSEPTGQQSGMTEYV-ATRWYRAPEVM 194 D+K N+L++S+ +CDFG A + TG +Y+ T + APEV+ Sbjct: 191 DVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTG------DYIPGTETHMAPEVV 244 Query: 195 LTSAKYSRAMDVWSCGCILAELF 217 L + ++ +DVWS C++ + Sbjct: 245 LGRSCDAK-VDVWSSCCMMLHML 266 >5UIU-A nrPDB Length = 323 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 93/207 (44%), Gaps = 17/207 (8%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPF-DKPLFALRTL--REIKILKHFKHENIITIF 75 +GEG +GVV T VA+KK+ D L+ +EIK++ +HEN++ + Sbjct: 55 MGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 112 Query: 76 NIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ-TLRAVKVLHGSNVI 134 VY+ + L + T LS H++ I Q + LH ++ I Sbjct: 113 GFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSW-HMRCKIAQGAANGINFLHENHHI 171 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 HRD+K +N+L++ K+ DFGLAR SE Q + V T Y APE + Sbjct: 172 HRDIKSANILLDEAFTAKISDFGLARA--------SEKFAQTVMTSRIVGTTAYMAPEAL 223 Query: 195 LTSAKYSRAMDVWSCGCILAELFLRRP 221 + + D++S G +L E+ P Sbjct: 224 --RGEITPKSDIYSFGVVLLEIITGLP 248 >5HIE-A nrPDB Length = 302 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 73/281 (25%), Positives = 131/281 (46%), Gaps = 36/281 (12%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +G G++G V K G+ VA+K + P + L A + E+ +L+ +H NI+ Sbjct: 44 IGSGSFGTVYKG--KWHGD-VAVKMLTP--QQLQAFKN--EVGVLRKTRHVNILLFMG-- 94 Query: 79 RPDSFENFNEVYIIQELMQTD-----LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNV 133 + ++ I+ + + LH +I T+ I QT + + LH ++ Sbjct: 95 ----YSTKPQLAIVTQWCEGSSLYHHLH-IIETKFEMIKLID-IARQTAQGMDYLHAKSI 148 Query: 134 IHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV 193 IHRDLK +N+ ++ + +K+ DFGLA + +S S Q SG ++ APEV Sbjct: 149 IHRDLKSNNIFLHEDLTVKIGDFGLATV--KSRWSGSHQFEQLSGSILWM------APEV 200 Query: 194 MLTSAK--YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCI 251 + K YS DV++ G +L EL + + + R Q++ ++G + DL + Sbjct: 201 IRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIF---MVGRGYLSPDLSKV 257 Query: 252 ES--PRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRML 290 S P+A + + + + +FP++ I+LL R L Sbjct: 258 RSNCPKAMKRLMAECLKKKRDERPLFPQI-LASIELLARSL 297 >3TXO-A nrPDB Length = 353 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/214 (23%), Positives = 99/214 (46%), Gaps = 27/214 (12%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR------TLREIKILKH 65 +F+ +LG+G++G V A K TG++ A+K + K L+ T+ E +IL Sbjct: 24 NFEFIRVLGKGSFGKVMLARVKETGDLYAVKVL----KKDVILQDDDVECTMTEKRILSL 79 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLR 123 ++ +T Q F+ + ++ + E + + + ++ + +++ + + Sbjct: 80 ARNHPFLT----QLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIIS 135 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 A+ LH +I+RDLK N+L++ K+ DFG+ + N T G +Y+ Sbjct: 136 ALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCK----EGICNGVTTATFCGTPDYI 191 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 APE+ L Y A+D W+ G +L E+ Sbjct: 192 ------APEI-LQEMLYGPAVDWWAMGVLLYEML 218 >3CJF-A nrPDB Length = 309 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 60/224 (26%), Positives = 99/224 (44%), Gaps = 26/224 (11%) Query: 19 LGEGAYGVVCSAT-----HKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE-NII 72 LG GA+G V A T VA+K ++ + E+KIL H H N++ Sbjct: 35 LGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVV 94 Query: 73 TIFN-IQRPDS-------FENFNEV--YIIQELMQTDLHRVISTQMLSDDHIQYFIYQTL 122 + +P F F + Y+ + + ++ + L+ +H+ + +Q Sbjct: 95 NLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVA 154 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + ++ L IHRDL N+L++ +K+CDFGLAR I +P + G Sbjct: 155 KGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI------YKDPDYVRKGDAR- 207 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFPG 225 + +W APE + Y+ DVWS G +L E+F L +PG Sbjct: 208 LPLKWM-APETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPG 249 >2I0E-A nrPDB Length = 353 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 52/223 (23%), Positives = 101/223 (45%), Gaps = 23/223 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK--KIEPFDKPLFALRTLREIKILKHFKH 68 +DF +LG+G++G V + K T E+ A+K K + + T+ E ++L Sbjct: 20 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 79 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 +T Q F+ + +Y + E + ++ + + H ++ + + Sbjct: 80 PPFLT----QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 135 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT--EYVA 184 L +I+RDLK N++++S +K+ DFG+ + E+ D G+T + Sbjct: 136 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWD---------GVTTKTFCG 183 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 T Y APE+ + Y +++D W+ G +L E+ + F G D Sbjct: 184 TPDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED 225 >4AW2-A nrPDB Length = 437 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 55/241 (22%), Positives = 114/241 (47%), Gaps = 35/241 (14%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH-----F 66 DF++ ++G GA+G V A+ K++ DK +FA++ L + ++LK F Sbjct: 75 DFEILKVIGRGAFGEV------------AVVKLKNADK-VFAMKILNKWEMLKRAETACF 121 Query: 67 KHENIITIFNIQR-----PDSFENFNEVYIIQEL-MQTDLHRVIST--QMLSDDHIQYFI 118 + E + + + +F++ N +Y++ + + DL ++S L ++ ++++ Sbjct: 122 REERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYL 181 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 + + A+ +H + +HRD+KP N+L++ N +++ DFG + E D + + G Sbjct: 182 AEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLME---DGTVQSSVAVG 238 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGI 238 +Y++ +A E +Y D WS G + E+ F Y L+ +G Sbjct: 239 TPDYISPEILQAMEG--GKGRYGPECDWWSLGVCMYEMLYGETPF----YAESLVETYGK 292 Query: 239 I 239 I Sbjct: 293 I 293 >6FER-A nrPDB Length = 309 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 59/240 (24%), Positives = 97/240 (40%), Gaps = 60/240 (25%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRT------------------ 56 K LGEG +G V + ++ +E F FAL Sbjct: 13 FKEKLGEGQFGEV---------HLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADAN 63 Query: 57 -------LREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVIS--- 105 L+EIKI+ K NII + + D + + +I E M+ DL++ +S Sbjct: 64 KNARNDFLKEIKIMSRLKDPNIIHLLAVCITD-----DPLCMITEYMENGDLNQFLSRHE 118 Query: 106 --------TQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFG 157 + +S ++++ Q +K L N +HRDL N L+ N +K+ DFG Sbjct: 119 PPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFG 178 Query: 158 LARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 ++R + + D G+ + RW ++L K++ A DVW+ G L E F Sbjct: 179 MSRNL--YSGDYYRIQGR-----AVLPIRWMSWESILL--GKFTTASDVWAFGVTLWETF 229 >5HI2-A nrPDB Length = 283 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 60/224 (26%), Positives = 103/224 (45%), Gaps = 26/224 (11%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +G G++G V K G+ VA+K + P + L A + E+ +L+ +H NI+ Sbjct: 28 IGSGSFGTVYKG--KWHGD-VAVKMLTP--QQLQAFKN--EVGVLRKTRHVNILLFMG-- 78 Query: 79 RPDSFENFNEVYIIQELMQTDL---HRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIH 135 + ++ I+ + + H S + QT R + LH ++IH Sbjct: 79 ----YSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIH 134 Query: 136 RDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV-- 193 RDLK +N+ ++ + +K+ DFGLA + +S S Q SG ++ APEV Sbjct: 135 RDLKSNNIFLHEDNTVKIGDFGLATV--KSRWSGSHQFEQLSGSILWM------APEVIR 186 Query: 194 MLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 M S YS DV++ G +L EL + + + R Q++ + G Sbjct: 187 MQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVG 230 >3V5Q-A nrPDB Length = 297 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 62/234 (26%), Positives = 98/234 (41%), Gaps = 34/234 (14%) Query: 12 DFQLKSLLGEGAYGVVCSA---THKPTGE--IVAIKKIEPFDKPLFALRT--LREIKILK 64 D LK LGEGA+G V A PT + +VA+K ++ P A R RE ++L Sbjct: 16 DIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALK---DPTLAARKDFQREAELLT 72 Query: 65 HFKHENI-------------ITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSD 111 + +HE+I I +F + F + ++ D + L Sbjct: 73 NLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGL 132 Query: 112 DHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSE 171 + + Q + L + +HRDL N L+ +N +K+ DFG++R D + D Sbjct: 133 SQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSR--DVYSTDYYR 190 Query: 172 PTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL--RRPIF 223 G + RW +M K++ DVWS G IL E+F ++P F Sbjct: 191 VGGH-----TMLPIRWMPPESIMYR--KFTTESDVWSFGVILWEIFTYGKQPWF 237 >3TT0-A nrPDB Length = 382 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 63/240 (26%), Positives = 98/240 (40%), Gaps = 53/240 (22%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-------------EIKILKH 65 LGEGA+G V A E + + K +P A++ L+ E++++K Sbjct: 77 LGEGAFGQVVLA------EAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM 130 Query: 66 F-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIST----------------- 106 KH+NII + D +Y+I E + +L + Sbjct: 131 IGKHKNIINLLGACTQDG-----PLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPE 185 Query: 107 QMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESA 166 + LS + YQ R ++ L IHRDL N+L+ + +K+ DFGLAR I Sbjct: 186 EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHID 245 Query: 167 ADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFPG 225 G+ + +W APE + Y+ DVWS G +L E+F L +PG Sbjct: 246 YYKKTTNGR-------LPVKWM-APEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPG 296 >4JLC-A nrPDB Length = 657 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 94/207 (45%), Gaps = 20/207 (9%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHFKHENII 72 L +LG+GA V HK TG++ A+K F +P+ +RE ++LK H+NI+ Sbjct: 12 LSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDV--QMREFEVLKKLNHKNIV 69 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHRVI----STQMLSDDHIQYFIYQTLRAVKVL 128 +F I+ + ++V I++ L+ V+ + L + + + + L Sbjct: 70 KLFAIEEETTTR--HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 127 Query: 129 HGSNVIHRDLKPSNLLI----NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + ++HRD+KP N++ + K+ DFG AR + ++ E G EY+ Sbjct: 128 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVSLYGTEEYLH 182 Query: 185 TRWY-RAPEVMLTSAKYSRAMDVWSCG 210 Y RA KY +D+WS G Sbjct: 183 PDMYERAVLRKDHQKKYGATVDLWSVG 209 >3PFQ-A nrPDB Length = 674 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 52/223 (23%), Positives = 101/223 (45%), Gaps = 23/223 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK--KIEPFDKPLFALRTLREIKILKHFKH 68 +DF +LG+G++G V + K T E+ A+K K + + T+ E ++L Sbjct: 341 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 400 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 +T Q F+ + +Y + E + ++ + + H ++ + + Sbjct: 401 PPFLT----QLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 456 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT--EYVA 184 L +I+RDLK N++++S +K+ DFG+ + E+ D G+T + Sbjct: 457 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK---ENIWD---------GVTTKTFCG 504 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 T Y APE+ + Y +++D W+ G +L E+ + F G D Sbjct: 505 TPDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED 546 >5IKW-A nrPDB Length = 310 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 63/219 (28%), Positives = 99/219 (45%), Gaps = 29/219 (13%) Query: 15 LKSLLGEGAYGVV-CSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HENII 72 L+ L EG + V TH G A+K++ + P + REI I+K H+NI+ Sbjct: 18 LEESLAEGGFSTVFLVRTHG--GIRCALKRMYVNNMPDLNV-CKREITIMKELSGHKNIV 74 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQT-----DLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 + +N EV I+ E + +++ + T + +Q F T AV Sbjct: 75 GYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFC-DTCEAVAR 133 Query: 128 LHGSN--VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT----- 180 LH +IHRDLK N+L+N + +CDFG +A N Q+ G+ Sbjct: 134 LHQCKTPIIHRDLKVENILLNDGGNYVLCDFG--------SATNKFLNPQKDGVNVVEEE 185 Query: 181 -EYVATRWYRAPEVM-LTSAK-YSRAMDVWSCGCILAEL 216 + T YRAPE++ L K + D+W+ GC+L +L Sbjct: 186 IKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKL 224 >4EUT-A nrPDB Length = 396 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 54/208 (25%), Positives = 94/208 (45%), Gaps = 20/208 (9%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHFKHENII 72 L +LG+GA V HK TG++ AIK F +P+ +RE ++LK H+NI+ Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV--QMREFEVLKKLNHKNIV 70 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHRVI----STQMLSDDHIQYFIYQTLRAVKVL 128 +F I+ + ++V I++ L+ V+ + L + + + + L Sbjct: 71 KLFAIEEETTTR--HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 128 Query: 129 HGSNVIHRDLKPSNLLI----NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + ++HR++KP N++ + K+ DFG AR +++ E G EY+ Sbjct: 129 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELED-----DEQFVSLYGTEEYLH 183 Query: 185 TRWY-RAPEVMLTSAKYSRAMDVWSCGC 211 Y RA KY +D+WS G Sbjct: 184 PDMYERAVLRKDHQKKYGATVDLWSIGV 211 >4G3E-A nrPDB Length = 352 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 50/203 (24%), Positives = 91/203 (44%), Gaps = 22/203 (10%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +G G++G V K TG A+KK+ + + E+ I+ ++ Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVR------LEVFRVEELVACAGLSSPRIVPLYGAV 135 Query: 79 RPDSFENFNEVYIIQELMQTDLHRVISTQM--LSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 R + N I EL++ + QM L +D Y++ Q L ++ LH ++H Sbjct: 136 REGPWVN-----IFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHG 190 Query: 137 DLKPSNLLINSNCD-LKVCDFGLARIIDESAADNSEPTGQQSGMTEYV-ATRWYRAPEVM 194 D+K N+L++S+ +CDFG A + S TG +Y+ T + APEV+ Sbjct: 191 DVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTG------DYIPGTETHMAPEVV 244 Query: 195 LTSAKYSRAMDVWSCGCILAELF 217 + ++ +D+WS C++ + Sbjct: 245 MGKPCDAK-VDIWSSCCMMLHML 266 >4X7Q-B nrPDB Length = 312 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 79/334 (23%), Positives = 134/334 (40%), Gaps = 78/334 (23%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPL----------FALRTLREI 60 ++++L LLG+G +G V A H+ T + K+ P ++ L L Sbjct: 31 AEYRLGPLLGKGGFGTV-FAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLW 89 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQE--LMQTDLHRVISTQM-LSDDHIQYF 117 K+ H +I + D FE ++ E L DL I+ + L + + F Sbjct: 90 KVGAGGGHPGVIRLL-----DWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCF 144 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLIN--SNCDLKVCDFGLARIIDESAADNSEPTGQ 175 Q + A++ H V+HRD+K N+LI+ C K+ DFG ++ + EP Sbjct: 145 FGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGC-AKLIDFGSGALL------HDEP--- 194 Query: 176 QSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLI 235 T++ TR Y PE + ++ VWS G +L Sbjct: 195 ---YTDFDGTRVYSPPEWISRHQYHALPATVWSLGILL---------------------- 229 Query: 236 FGIIGTPHSDNDLRCIESP--RAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFD 293 D+ C + P R +E +++ +PA V+P L++R L Sbjct: 230 ----------YDMVCGDIPFERDQEILEAELHFPA--------HVSPDCCALIRRCLAPK 271 Query: 294 PAKRITAKEALEHPYLQTYHD--PNDEPEGEPIP 325 P+ R + +E L P++QT + P + +G P P Sbjct: 272 PSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAP 305 >6O8B-A nrPDB Length = 665 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 95/207 (45%), Gaps = 20/207 (9%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHFKHENII 72 L +LG+GA V HK TG++ AIK F +P+ +RE ++LK H+NI+ Sbjct: 19 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV--QMREFEVLKKLNHKNIV 76 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHRVI----STQMLSDDHIQYFIYQTLRAVKVL 128 +F I+ + ++V I++ L+ V+ + L + + + + L Sbjct: 77 KLFAIEEETTTR--HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 134 Query: 129 HGSNVIHRDLKPSNLLI----NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + ++HR++KP N++ + K+ DFG AR + ++ E + G EY+ Sbjct: 135 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVELYGTEEYLH 189 Query: 185 TRWY-RAPEVMLTSAKYSRAMDVWSCG 210 Y RA KY +D+WS G Sbjct: 190 PDMYERAVLRKDHQKKYGATVDLWSIG 216 >3GQL-A nrPDB Length = 326 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 64/236 (27%), Positives = 99/236 (41%), Gaps = 45/236 (19%) Query: 19 LGEGAYGVVCSAT---------HKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF-KH 68 LGEGA+G V A ++ T V + K + +K L L + E++++K KH Sbjct: 36 LGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL--ISEMEMMKMIGKH 93 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIST-----------------QMLS 110 +NII + D +Y+I E + +L + + LS Sbjct: 94 KNIINLLGACTQDG-----PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLS 148 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 + YQ R ++ L IHRDL N+L+ + +K+ DFGLAR I Sbjct: 149 SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKK 208 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFPG 225 G+ + +W APE + Y+ DVWS G +L E+F L +PG Sbjct: 209 TTNGR-------LPVKWM-APEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPG 255 >6FEX-A nrPDB Length = 321 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 61/239 (25%), Positives = 98/239 (41%), Gaps = 45/239 (18%) Query: 11 SDFQLKSLLGEGAYGVV--CSA--------------THKPTGEIVAIKKIEPFDKPLFAL 54 S + K LGEG +G V C K +VA+K + P Sbjct: 16 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARN 75 Query: 55 RTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQMLSDDH 113 L+E+KI+ K NII + + D + + +I + M+ DL++ +S L D Sbjct: 76 DFLKEVKIMSRLKDPNIIRLLGVCVQD-----DPLCMITDYMENGDLNQFLSAHQLEDKA 130 Query: 114 IQ--------------YFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLA 159 + + Q ++ L N +HRDL N L+ N +K+ DFG++ Sbjct: 131 AEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMS 190 Query: 160 RIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL 218 R + A D G+ + RW A E +L K++ A DVW+ G L E+ + Sbjct: 191 RNL--YAGDYYRVQGR-----AVLPIRWM-AWECILM-GKFTTASDVWAFGVTLWEVLM 240 >5E8V-A nrPDB Length = 316 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 109/227 (48%), Gaps = 30/227 (13%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTG----EIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 +L +L+G+G + V A K E VA+K I P+++ + +T ++I + KH Sbjct: 11 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVK-IFPYEE-YASWKTEKDIFSDINLKH 68 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQEL-MQTDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 ENI+ + + E + ++I + +L ++ ++S + ++ R + Sbjct: 69 ENILQFLTAEERKT-ELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH 127 Query: 128 LHGSN---------VIHRDLKPSNLLINSNCDLKVCDFGLARIIDES-AADNSEPTGQQS 177 LH + ++HRDLK SN+L+ ++ +CDFGL+ +D + + D+ +GQ Sbjct: 128 LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQ-- 185 Query: 178 GMTEYVATRWYRAPEVM-----LTSAKYSRAMDVWSCGCILAELFLR 219 V T Y APEV+ L + + + DV+S +L E+ R Sbjct: 186 -----VGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSR 227 >4EUU-A nrPDB Length = 319 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 94/207 (45%), Gaps = 20/207 (9%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHFKHENII 72 L +LG+GA V HK TG++ AIK F +P+ +RE ++LK H+NI+ Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV--QMREFEVLKKLNHKNIV 70 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHRVI----STQMLSDDHIQYFIYQTLRAVKVL 128 +F I+ + ++V I++ L+ V+ + L + + + + L Sbjct: 71 KLFAIEEETTTR--HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 128 Query: 129 HGSNVIHRDLKPSNLLI----NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + ++HR++KP N++ + K+ DFG AR +++ E G EY+ Sbjct: 129 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELED-----DEQFVSLYGTEEYLH 183 Query: 185 TRWY-RAPEVMLTSAKYSRAMDVWSCG 210 Y RA KY +D+WS G Sbjct: 184 PDMYERAVLRKDHQKKYGATVDLWSIG 210 >5X02-A nrPDB Length = 347 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 61/240 (25%), Positives = 100/240 (41%), Gaps = 51/240 (21%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEI-----VAIKKIEPFDKPLFALRTLREIKILKHF 66 + + +LG GA+G V +AT + VA+K ++ + E+K++ Sbjct: 49 NLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQL 108 Query: 67 -KHENIITIFN---IQRPDSFENFNEVYIIQE-LMQTDLHRVIST--QMLSDDHIQY--- 116 HENI+ + + P +Y+I E DL + + + S+D I+Y Sbjct: 109 GSHENIVNLLGACTLSGP--------IYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQ 160 Query: 117 -------------------FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFG 157 F YQ + ++ L + +HRDL N+L+ +K+CDFG Sbjct: 161 KRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFG 220 Query: 158 LARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 LAR D + N G + +W APE + Y+ DVWS G +L E+F Sbjct: 221 LAR--DIMSDSNYVVRGNAR-----LPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIF 271 >1U54-B nrPDB Length = 291 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 94/215 (43%), Gaps = 24/215 (11%) Query: 12 DFQLKSLLGEGAYGVVCSAT-HKPTGEIV--AIKKIEP--FDKPLFALRTLREIKILKHF 66 D +L LG+G++GVV P+G+ V A+K ++P +P +RE+ + Sbjct: 19 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 78 Query: 67 KHENIITIFNIQRPDSFENFNEVY----IIQELMQTDLHRVISTQMLSDDHIQYFIYQTL 122 H N+I ++ + + E+ ++ L + H ++ T + + Q Sbjct: 79 DHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGT-------LSRYAVQVA 131 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + L IHRDL NLL+ + +K+ DFGL R + + ++ Q+ + Sbjct: 132 EGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQ---NDDHYVMQEHRKVPF 188 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 + APE + T +S A D W G L E+F Sbjct: 189 A----WCAPESLKTRT-FSHASDTWMFGVTLWEMF 218 >4YHJ-A nrPDB Length = 584 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 98/210 (46%), Gaps = 23/210 (10%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA--LRTLREIKILKHFKHEN 70 F+ +LG+G +G VC+ + TG++ A KK++ L E +IL E Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRIL-----EK 241 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI---STQMLSDDHIQYFIYQTLRAVK 126 + + F + ++E + + ++ +M DL I + ++ + ++ Sbjct: 242 VQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLE 301 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L +++RDLKP N+L++ +++ D GLA I P GQ+ + V T Sbjct: 302 DLQRERIVYRDLKPENILLDDRGHIRISDLGLATEI---------PEGQR--VRGRVGTV 350 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 Y APEV + + KY+ + D W GC++ E+ Sbjct: 351 GYMAPEV-VNNEKYTFSPDWWGLGCLIYEM 379 >4K33-A nrPDB Length = 325 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 62/236 (26%), Positives = 98/236 (41%), Gaps = 45/236 (19%) Query: 19 LGEGAYGVVCSA---------THKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF-KH 68 LGEGA+G V A KP V + K + DK L L + E++++K KH Sbjct: 44 LGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDL--VSEMEMMKMIGKH 101 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQE-LMQTDLHRVIST-----------------QMLS 110 +NII + + +Y++ E + +L + + L+ Sbjct: 102 KNIINLLG-----ACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLT 156 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 + YQ R ++ L IHRDL N+L+ + +K+ DFGLAR + Sbjct: 157 FKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKE 216 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFPG 225 G+ + +W APE + Y+ DVWS G +L E+F L +PG Sbjct: 217 TTNGR-------LPVKWM-APEALFDRV-YTHQSDVWSFGVLLWEIFTLGGSPYPG 263 >3UIU-A nrPDB Length = 306 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 55/243 (22%), Positives = 100/243 (41%), Gaps = 63/243 (25%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 DF+ L+G G +G V A H+ G+ I++++ ++ + RE+K L H NI Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNE-----KAEREVKALAKLDHVNI 67 Query: 72 ITIFNI---------QRPDSFEN------------------------FNEVYIIQELMQT 98 + DS E+ F + +++ ++ Sbjct: 68 VHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK 127 Query: 99 ----DLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVC 154 L +V++ ++ Q + V +H +IHRDLKPSN+ + +K+ Sbjct: 128 RRGEKLDKVLALELFE---------QITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIG 178 Query: 155 DFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILA 214 DFGL ++ N + G Y+ +PE ++S Y + +D+++ G ILA Sbjct: 179 DFGLV-----TSLKNDGKRTRSKGTLRYM------SPE-QISSQDYGKEVDLYALGLILA 226 Query: 215 ELF 217 EL Sbjct: 227 ELL 229 >5TOS-A nrPDB Length = 395 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 103/227 (45%), Gaps = 36/227 (15%) Query: 10 SSDFQLKSLLGEGAYGVV---------CSATHKPTGEIVAIKKI--EPFDKPLFALRTLR 58 + +F+ S++GEG +G V + T TG ++A+KK+ E F L Sbjct: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG---HREWLT 120 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFI 118 EI L H N++ + E+ + + + + + + L + + + +F+ Sbjct: 121 EINYLGQLSHPNLVKLIGY----CLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 Query: 119 -----YQTLRAVKVLHGS--NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSE 171 + + LH VI+RD+K SN+L++++ + K+ DFGLAR Sbjct: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR---------DG 227 Query: 172 PTGQQSGM-TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 P G S + T + T Y APE M + +R+ DV+S G +L E+ Sbjct: 228 PMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARS-DVYSFGVLLLEIL 273 >4XUF-A nrPDB Length = 297 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 60/237 (25%), Positives = 98/237 (41%), Gaps = 45/237 (18%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEI-----VAIKKIEPFDKPLFALRTLREIKILKHF 66 + + +LG GA+G V +AT + VA+K ++ + E+K++ Sbjct: 10 NLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQL 69 Query: 67 -KHENIITIFNIQRPDSFENFNEVYIIQE-LMQTDLHRVIST--QMLSDDHIQY------ 116 HENI+ + +Y+I E DL + + + S+D I+Y Sbjct: 70 GSHENIVNLLGACTLSG-----PIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRL 124 Query: 117 ----------------FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLAR 160 F YQ + ++ L + +HRDL N+L+ +K+CDFGLAR Sbjct: 125 EEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLAR 184 Query: 161 IIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 D + N G + +W APE + Y+ DVWS G +L E+F Sbjct: 185 --DIMSDSNYVVRGNAR-----LPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIF 232 >1AD5-A nrPDB Length = 438 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 96/218 (44%), Gaps = 34/218 (15%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +L+ LG G +G V AT+ + VA+K ++P + A L E ++K +H+ ++ Sbjct: 184 LKLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMSVEAF--LAEANVMKTLQHDKLV 240 Query: 73 TIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDHIQYFI---YQTLRAVKVL 128 + + + +YII E M + L + + S + I Q + + Sbjct: 241 KLHAVVTKEP------IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFI 294 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 N IHRDL+ +N+L++++ K+ DFGLAR+ +W Sbjct: 295 EQRNYIHRDLRAANILVSASLVCKIADFGLARV------------------GAKFPIKW- 335 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPI-FPG 225 APE + ++ DVWS G +L E+ I +PG Sbjct: 336 TAPEA-INFGSFTIKSDVWSFGILLMEIVTYGRIPYPG 372 >6NT9-A nrPDB Length = 742 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 94/207 (45%), Gaps = 20/207 (9%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHFKHENII 72 L +LG+GA V HK TG++ AIK F +P+ +RE ++LK H+NI+ Sbjct: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDV--QMREFEVLKKLNHKNIV 68 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHRVI----STQMLSDDHIQYFIYQTLRAVKVL 128 +F I+ + ++V I++ L+ V+ + L + + + + L Sbjct: 69 KLFAIEEETTTR--HKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 Query: 129 HGSNVIHRDLKPSNLLI----NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + ++HR++KP N++ + K+ DFG AR + ++ E G EY+ Sbjct: 127 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVSLYGTEEYLH 181 Query: 185 TRWY-RAPEVMLTSAKYSRAMDVWSCG 210 Y RA KY +D+WS G Sbjct: 182 PDMYERAVLRKDHQKKYGATVDLWSIG 208 >2OGV-A nrPDB Length = 317 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 65/240 (27%), Positives = 103/240 (42%), Gaps = 39/240 (16%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHKPTGE-----IVAIKKIEPFDKPL 51 P ++ YN +F Q LG GA+G V AT G+ VA+K ++ Sbjct: 24 PTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD 83 Query: 52 FALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQEL-----MQTDLHRVIS 105 + E+KI+ H +HENI+ + + + V +I E + L R Sbjct: 84 EKEALMSELKIMSHLGQHENIVNLLG-----ACTHGGPVLVITEYCCYGDLLNFLRRKAE 138 Query: 106 TQMLSDDH-------IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGL 158 + +D + +F Q + + L N IHRD+ N+L+ + K+ DFGL Sbjct: 139 ADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGL 198 Query: 159 AR-IIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 AR I+++S N G + +W APE + Y+ DVWS G +L E+F Sbjct: 199 ARDIMNDS---NYIVKGNAR-----LPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIF 248 >4HZS-A nrPDB Length = 341 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 94/215 (43%), Gaps = 24/215 (11%) Query: 12 DFQLKSLLGEGAYGVVCSAT-HKPTGEIV--AIKKIEP--FDKPLFALRTLREIKILKHF 66 D +L LG+G++GVV P+G+ V A+K ++P +P +RE+ + Sbjct: 13 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 72 Query: 67 KHENIITIFNIQRPDSFENFNEVY----IIQELMQTDLHRVISTQMLSDDHIQYFIYQTL 122 H N+I ++ + + E+ ++ L + H ++ T + + Q Sbjct: 73 DHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGT-------LSRYAVQVA 125 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + L IHRDL NLL+ + +K+ DFGL R + + ++ Q+ + Sbjct: 126 EGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQ---NDDHYVMQEHRKVPF 182 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 + APE + T +S A D W G L E+F Sbjct: 183 A----WCAPESLKTRT-FSHASDTWMFGVTLWEMF 212 >3KRL-A nrPDB Length = 335 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 66/246 (26%), Positives = 103/246 (41%), Gaps = 45/246 (18%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHKPTGE-----IVAIKKIEPFDKPL 51 P ++ YN +F Q LG GA+G V AT G+ VA+K ++ Sbjct: 32 PTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD 91 Query: 52 FALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQE-LMQTDLHRVIS---- 105 + E+KI+ H +HENI+ + + + V +I E DL + Sbjct: 92 EKEALMSELKIMSHLGQHENIVNLLG-----ACTHGGPVLVITEYCCYGDLLNFLRRKRP 146 Query: 106 -------------TQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLK 152 + LS + +F Q + + L N IHRD+ N+L+ + K Sbjct: 147 PGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAK 206 Query: 153 VCDFGLAR-IIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGC 211 + DFGLAR I+++S N G + +W APE + Y+ DVWS G Sbjct: 207 IGDFGLARDIMNDS---NYIVKGNAR-----LPVKW-MAPESIFDCV-YTVQSDVWSYGI 256 Query: 212 ILAELF 217 +L E+F Sbjct: 257 LLWEIF 262 >6GVJ-A nrPDB Length = 429 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 76/315 (24%), Positives = 127/315 (40%), Gaps = 60/315 (19%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-EIKILKHFKH--ENIITIF 75 +G G V ++ +I AIK + + L + R EI L + + II ++ Sbjct: 152 IGSGGSSKVFQVLNE-KKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLY 210 Query: 76 NIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDD-HIQYFIYQTLRAVKVLHGSNVI 134 + + D + +Y++ E DL+ + + D + + L AV +H ++ Sbjct: 211 DYEITDQY-----IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIV 265 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 H DLKP+N LI LK+ DFG+ A+ +P V T Y PE + Sbjct: 266 HSDLKPANFLIVDGM-LKLIDFGI--------ANQMQPDTTSVVKDSQVGTVNYMPPEAI 316 Query: 195 --LTSAKYS--------RAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 ++S++ + DVWS GCIL ++ P + +Q+ + II H Sbjct: 317 KDMSSSRENGKSKSKISPKSDVWSLGCIL--YYMTYGKTPFQQIINQISKLHAIIDPNH- 373 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFDPAKRITAKEA 303 E FP + K + D+L+ L DP +RI+ E Sbjct: 374 ---------------------------EIEFPDIPEKDLQDVLKCCLKRDPKQRISIPEL 406 Query: 304 LEHPYLQTYHDPNDE 318 L HPY+Q P ++ Sbjct: 407 LAHPYVQIQTHPVNQ 421 >3HMP-A nrPDB Length = 342 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 76/312 (24%), Positives = 125/312 (40%), Gaps = 60/312 (19%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-EIKILKHFKH--ENIITIF 75 +G G V ++ +I AIK + + L + R EI L + + II ++ Sbjct: 64 IGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLY 122 Query: 76 NIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDD-HIQYFIYQTLRAVKVLHGSNVI 134 + + D + +Y++ E DL+ + + D + + L AV +H ++ Sbjct: 123 DYEITDQY-----IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIV 177 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 H DLKP+N LI LK+ DFG+ A+ +P V T Y PE + Sbjct: 178 HSDLKPANFLIVDGM-LKLIDFGI--------ANQMQPDTTSVVKDSQVGTVNYMPPEAI 228 Query: 195 --LTSAKYS--------RAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 ++S++ + DVWS GCIL ++ P + +Q+ + II H Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCIL--YYMTYGKTPFQQIINQISKLHAIIDPNH- 285 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFDPAKRITAKEA 303 E FP + K + D+L+ L DP +RI+ E Sbjct: 286 ---------------------------EIEFPDIPEKDLQDVLKCCLKRDPKQRISIPEL 318 Query: 304 LEHPYLQTYHDP 315 L HPY+Q P Sbjct: 319 LAHPYVQIQTHP 330 >3C51-A nrPDB Length = 543 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 96/217 (44%), Gaps = 24/217 (11%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA--LRTLREIKILKHFKHENIITIF 75 +LG G +G V + K TG++ A KK+ + E KIL I+++ Sbjct: 192 VLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSL- 250 Query: 76 NIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDD------HIQYFIYQTLRAVKVLH 129 +FE ++ ++ +M R + D+ ++ Q + ++ LH Sbjct: 251 ----AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLH 306 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 N+I+RDLKP N+L++ + ++++ D GLA E Q+ Y T + Sbjct: 307 QRNIIYRDLKPENVLLDDDGNVRISDLGLA----------VELKAGQTKTKGYAGTPGFM 356 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGR 226 APE++L +Y ++D ++ G L E+ R F R Sbjct: 357 APELLL-GEEYDFSVDYFALGVTLYEMIAARGPFRAR 392 >5C26-A nrPDB Length = 299 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 90/206 (43%), Gaps = 23/206 (11%) Query: 19 LGEGAYGVVCSATHK----PTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITI 74 LG G +G V ++ V I K E D P L E +++ + I+ + Sbjct: 35 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAND-PALKDELLAEANVMQQLDNPYIVRM 93 Query: 75 FNIQRPDSFE---NFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGS 131 I +S+ E+ + + +Q + H + D +I ++Q +K L S Sbjct: 94 IGICEAESWMLVMEMAELGPLNKYLQQNRH-------VKDKNIIELVHQVSMGMKYLEES 146 Query: 132 NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 N +HRDL N+L+ + K+ DFGL++ + AD + Q G +WY AP Sbjct: 147 NFVHRDLAARNVLLVTQHYAKISDFGLSKAL---RADENYYKAQTHGKW---PVKWY-AP 199 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELF 217 E + K+S DVWS G ++ E F Sbjct: 200 EC-INYYKFSSKSDVWSFGVLMWEAF 224 >4FL3-A nrPDB Length = 635 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 90/206 (43%), Gaps = 23/206 (11%) Query: 19 LGEGAYGVVCSATHK----PTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITI 74 LG G +G V ++ V I K E D P L E +++ + I+ + Sbjct: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAND-PALKDELLAEANVMQQLDNPYIVRM 435 Query: 75 FNIQRPDSFE---NFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGS 131 I +S+ E+ + + +Q + H + D +I ++Q +K L S Sbjct: 436 IGICEAESWMLVMEMAELGPLNKYLQQNRH-------VKDKNIIELVHQVSMGMKYLEES 488 Query: 132 NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 N +HRDL N+L+ + K+ DFGL++ + AD + Q G +WY AP Sbjct: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKAL---RADENYYKAQTHGKW---PVKWY-AP 541 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELF 217 E + K+S DVWS G ++ E F Sbjct: 542 EC-INYYKFSSKSDVWSFGVLMWEAF 566 >3BBT-B nrPDB Length = 328 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 56/235 (23%), Positives = 100/235 (42%), Gaps = 26/235 (11%) Query: 2 PKRIVYNISSDFQLK--SLLGEGAYGVVCSATHKPTGEIV----AIKKIEPFDKPLFALR 55 P + I + +LK +LG GA+G V P GE V AIK + P + Sbjct: 4 PNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE 63 Query: 56 TLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHR-VISTQMLSDDH 113 + E I+ H +++ + + + + ++ L++ H+ I +Q+L + Sbjct: 64 FMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLN-- 121 Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPT 173 + Q + + L ++HRDL N+L+ S +K+ DFGLAR+++ + + Sbjct: 122 ---WCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG 178 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDY 228 G+ + YR K++ DVWS G + EL F G+ Y Sbjct: 179 GKMPIKWMALECIHYR---------KFTHQSDVWSYGVTIWELM----TFGGKPY 220 >3HNG-A nrPDB Length = 360 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 43/116 (37%), Positives = 61/116 (52%), Gaps = 11/116 (9%) Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 +D I Y +Q R ++ L IHRDL N+L++ N +K+CDFGLAR I ++ Sbjct: 199 EDLISY-SFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN----- 252 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFPG 225 P + G T + +W APE + YS DVWS G +L E+F L +PG Sbjct: 253 -PDYVRKGDTR-LPLKWM-APESIFDKI-YSTKSDVWSYGVLLWEIFSLGGSPYPG 304 >4EBW-A nrPDB Length = 304 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 96/216 (44%), Gaps = 32/216 (14%) Query: 14 QLKSLLGEGAYGVVCSATH---KPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +L +GEG +G V + + VAIK + + L+E ++ F H + Sbjct: 41 ELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPH 100 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDD--HIQYFIYQTLRAVKV 127 I+ + + N V+II EL +L + + S D + + YQ A+ Sbjct: 101 IVKLIGVITE------NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAY 154 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 L +HRD+ N+L++SN +K+ DFGL+R +++S T Y A++ Sbjct: 155 LESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDS--------------TYYKASKG 200 Query: 188 -----YRAPEVMLTSAKYSRAMDVWSCGCILAELFL 218 + APE + +++ A DVW G + E+ + Sbjct: 201 KLPIKWMAPES-INFRRFTSASDVWMFGVCMWEILM 235 >5A46-A nrPDB Length = 386 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 62/240 (25%), Positives = 97/240 (40%), Gaps = 53/240 (22%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-------------EIKILKH 65 LGEG +G V A E + + K +P A++ L+ E++++K Sbjct: 48 LGEGCFGQVVLA------EAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM 101 Query: 66 F-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIST----------------- 106 KH+NII + D +Y+I E + +L + Sbjct: 102 IGKHKNIINLLGACTQD-----GPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPE 156 Query: 107 QMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESA 166 + LS + YQ R ++ L IHRDL N+L+ + +K+ DFGLAR I Sbjct: 157 EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHID 216 Query: 167 ADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFPG 225 G+ + +W APE + Y+ DVWS G +L E+F L +PG Sbjct: 217 YYKKTTNGR-------LPVKWM-APEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPG 267 >4XCU-A nrPDB Length = 300 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 62/227 (27%), Positives = 98/227 (43%), Gaps = 36/227 (15%) Query: 19 LGEGAYGVVCSA-------THKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHF-KH 68 LGEG +G V A VA+K ++ DK L L + E++++K +H Sbjct: 25 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADL--VSEMEVMKLIGRH 82 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVI--------STQMLSDDHIQYFIY 119 +NII + + + +Y+I E + +L + S LS + Y Sbjct: 83 KNIINLLGVCTQE-----GPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAY 137 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 Q R ++ L IHRDL N+L+ + +K+ DFGLAR + G+ Sbjct: 138 QVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGR---- 193 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFPG 225 + +W APE + Y+ DVWS G +L E+F L +PG Sbjct: 194 ---LPVKWM-APEALFDRV-YTHQSDVWSFGILLWEIFTLGGSPYPG 235 >2ZMD-A nrPDB Length = 390 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 72/286 (25%), Positives = 117/286 (40%), Gaps = 43/286 (15%) Query: 37 EIVAIKKIEPFDKPLFALRTLR-EIKILKHFKH--ENIITIFNIQRPDSFENFNEVYIIQ 93 +I AIK + + L + R EI L + + II +++ + D + +Y++ Sbjct: 81 QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQY-----IYMVM 135 Query: 94 ELMQTDLHRVISTQMLSDD-HIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLK 152 E DL+ + + D + + L AV +H ++H DLKP+N LI LK Sbjct: 136 ECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGM-LK 194 Query: 153 VCDFGLARII--DESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCG 210 + DFG+A + D ++ G + M + E + +K S DVWS G Sbjct: 195 LIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLG 254 Query: 211 CILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAP 270 CIL ++ P + +Q+ + II H Sbjct: 255 CIL--YYMTYGKTPFQQIINQISKLHAIIDPNH--------------------------- 285 Query: 271 LEKMFPRVNPKGI-DLLQRMLVFDPAKRITAKEALEHPYLQTYHDP 315 E FP + K + D+L+ L DP +RI+ E L HPY+Q P Sbjct: 286 -EIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHP 330 >6BFN-A nrPDB Length = 342 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 62/223 (27%), Positives = 102/223 (45%), Gaps = 24/223 (10%) Query: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRT--LREI 60 R +N S + ++ GEG +G V A + T + A+K++ E D A++ L E+ Sbjct: 19 RGTHNFSEELKI----GEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEV 72 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM---LSDDHIQYF 117 + L F+H NI+ + F ++ ++ LH TQ LS Sbjct: 73 EQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLH--CQTQACPPLSWPQRLDI 130 Query: 118 IYQTLRAVKVLH--GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQ 175 + T RA++ LH ++IH D+K SN+L++ K+ DFGLAR S S P+ Sbjct: 131 LLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARF---SRFAGSSPS-- 185 Query: 176 QSGM---TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAE 215 QS M T+ V PE + + + + D +S G ++ E Sbjct: 186 QSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLE 228 >5AP3-A nrPDB Length = 313 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 76/312 (24%), Positives = 125/312 (40%), Gaps = 60/312 (19%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-EIKILKHFKH--ENIITIF 75 +G G V ++ +I AIK + + L + R EI L + + II ++ Sbjct: 36 IGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLY 94 Query: 76 NIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDD-HIQYFIYQTLRAVKVLHGSNVI 134 + + D + +Y++ E DL+ + + D + + L AV +H ++ Sbjct: 95 DYEITDQY-----IYMVMECGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIV 149 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 H DLKP+N LI LK+ DFG+ A+ +P V T Y PE + Sbjct: 150 HSDLKPANFLIVDGM-LKLIDFGI--------ANQMQPDTTSVVKDSQVGTVNYMPPEAI 200 Query: 195 --LTSAKYS--------RAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 ++S++ + DVWS GCIL ++ P + +Q+ + II H Sbjct: 201 KDMSSSRENGKSKSKISPKSDVWSLGCIL--YYMTYGKTPFQQIINQISKLHAIIDPNH- 257 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFDPAKRITAKEA 303 E FP + K + D+L+ L DP +RI+ E Sbjct: 258 ---------------------------EIEFPDIPEKDLQDVLKCCLKRDPKQRISIPEL 290 Query: 304 LEHPYLQTYHDP 315 L HPY+Q P Sbjct: 291 LAHPYVQIQTHP 302 >3A8W-A nrPDB Length = 345 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 49/216 (22%), Positives = 97/216 (44%), Gaps = 19/216 (8%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 DF L ++G G+Y V K T I A+K ++ + + + ++ KH + Sbjct: 10 DFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKK--ELVNDDEDIDWVQTEKHVFEQAS 67 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 F + F+ + ++ + E + + + + L ++H +++ + A+ LH Sbjct: 68 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLH 127 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT--EYVATRW 187 +I+RDLK N+L++S +K+ D+G+ + G + G T + T Sbjct: 128 ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCK------------EGLRPGDTTSTFCGTPN 175 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 Y APE+ L Y ++D W+ G ++ E+ R F Sbjct: 176 YIAPEI-LRGEDYGFSVDWWALGVLMFEMMAGRSPF 210 >2H34-A nrPDB Length = 309 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 59/217 (27%), Positives = 98/217 (45%), Gaps = 19/217 (8%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLREIKILKHFKHEN 70 ++L+ L+G G G V A IVA+K + P+F R RE + + + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM-LSDDHIQYFIYQTLRAVKVL 128 ++ I + D ++Y+ L+ DL ++ Q L+ + Q A+ Sbjct: 96 VVPIHDFGEID-----GQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAA 150 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H + HRD+KP N+L++++ + DFG+A SA + + T Q G T V T +Y Sbjct: 151 HAAGATHRDVKPENILVSADDFAYLVDFGIA-----SATTDEKLT--QLGNT--VGTLYY 201 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG 225 APE S RA D+++ C+L E P + G Sbjct: 202 MAPERFSESHATYRA-DIYALTCVLYECLTGSPPYQG 237 >6BSD-A nrPDB Length = 876 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 61/245 (24%), Positives = 98/245 (40%), Gaps = 51/245 (20%) Query: 11 SDFQLKSLLGEGAYGVV--CSA--------------THKPTGEIVAIKKIEPFDKPLFAL 54 S + K LGEG +G V C K +VA+K + P Sbjct: 571 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARN 630 Query: 55 RTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQMLSDDH 113 L+E+KI+ K NII + + D + + +I + M+ DL++ +S L D Sbjct: 631 DFLKEVKIMSRLKDPNIIRLLGVCVQD-----DPLCMITDYMENGDLNQFLSAHQLEDKA 685 Query: 114 IQ--------------------YFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKV 153 + + Q ++ L N +HRDL N L+ N +K+ Sbjct: 686 AEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKI 745 Query: 154 CDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCIL 213 DFG++R + A D G+ + RW A E +L K++ A DVW+ G L Sbjct: 746 ADFGMSRNL--YAGDYYRVQGRA-----VLPIRWM-AWECILM-GKFTTASDVWAFGVTL 796 Query: 214 AELFL 218 E+ + Sbjct: 797 WEVLM 801 >2J0K-A nrPDB Length = 656 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 56/230 (24%), Positives = 100/230 (43%), Gaps = 33/230 (14%) Query: 1 MPKRIVYNISSD-FQLKSLLGEGAYGVVCSATH---KPTGEIVAIKKIEPFDKPLFALRT 56 MP Y I + +L +GEG +G V + + VAIK + + Sbjct: 379 MPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKF 438 Query: 57 LREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDD--H 113 L+E ++ F H +I+ + + N V+II EL +L + + S D Sbjct: 439 LQEALTMRQFDHPHIVKLIGVITE------NPVWIIMELCTLGELRSFLQVRKFSLDLAS 492 Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPT 173 + + YQ A+ L +HRD+ N+L+++ +K+ DFGL+R +++S Sbjct: 493 LILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDS-------- 544 Query: 174 GQQSGMTEYVATRW-----YRAPEVMLTSAKYSRAMDVWSCGCILAELFL 218 T Y A++ + APE + +++ A DVW G + E+ + Sbjct: 545 ------TYYKASKGKLPIKWMAPE-SINFRRFTSASDVWMFGVCMWEILM 587 >2JD5-A nrPDB Length = 373 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 68/274 (24%), Positives = 112/274 (40%), Gaps = 47/274 (17%) Query: 60 IKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIY 119 +K+L HF H+ + + FE E + L++ HR I +++ Sbjct: 89 LKLLDHFNHKGPNGVHVVM---VFEVLGENLL--ALIKKYEHRGIPLI-----YVKQISK 138 Query: 120 QTLRAVKVLHG-SNVIHRDLKPSNLLIN------SNCDLKVCDFGLARIIDESAADNSEP 172 Q L + +H +IH D+KP N+L+ + +K+ D G A DE Sbjct: 139 QLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEH------- 191 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF--------- 223 T + TR YR+PEV+L A + D+WS C++ EL +F Sbjct: 192 ------YTNSIQTREYRSPEVLL-GAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYT 244 Query: 224 PGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKM------FPR 277 D+ Q++ + G + + N +R ++++ PLE + F + Sbjct: 245 KDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSK 304 Query: 278 VNPKGI-DLLQRMLVFDPAKRITAKEALEHPYLQ 310 K I D L ML DP KR A + HP+L+ Sbjct: 305 DEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLK 338 >4Y83-A nrPDB Length = 332 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 82/295 (27%), Positives = 125/295 (42%), Gaps = 48/295 (16%) Query: 1 MPKRIVY-NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTL 57 +P ++ Y NI SDF + GA+G V A T + +A K I P D KP Sbjct: 67 IPWKLTYRNIGSDF-----IPRGAFGKVYLAQDIKTKKRMACKLI-PVDQFKP------- 113 Query: 58 REIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQ 115 +++I F+HENI ++ + V++ E + L ++ S + + I Sbjct: 114 SDVEIQACFRHENIAELYG-----AVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEII 168 Query: 116 YFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQ 175 + L+ + LH VIH D+KPSN++ S + V DFGL+ + E + G Sbjct: 169 WVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLV-DFGLSVQMTEDVYFPKDLRG- 226 Query: 176 QSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH---QL 232 T Y +PEV+L ++A D++S G L + P + R R Sbjct: 227 ---------TEIYMSPEVILCRGHSTKA-DIYSLGATLIHMQTGTPPWVKRYPRSAYPSY 276 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQ 287 L I P D C SP RE I+ A LE+ P P+ DLL+ Sbjct: 277 LYIIHKQAPPLEDIADDC--SPGMRELIE-------ASLERN-PNHRPRAADLLK 321 >5WNO-A nrPDB Length = 330 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 61/231 (26%), Positives = 97/231 (41%), Gaps = 42/231 (18%) Query: 4 RIVYNISSDFQLK--SLLGEGAYGVVCSATHKPTGEI-----VAIKKIEPFDKP------ 50 RI SS+ Q K LG GA+G V + + P VAIK + Sbjct: 13 RICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLE 72 Query: 51 ----LFALRTLREIKILKHFKHENIITIFNIQRP-DSFENFNEVYIIQELMQTDLHRVIS 105 +F LR +KI+ H++ + I I RP + +NF LH+ Sbjct: 73 EATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNF-----------LKLHK--- 118 Query: 106 TQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDES 165 + L + YQ ++ L V+HRDL N+L+ +++ DFGL++I+ Sbjct: 119 -ENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHD 177 Query: 166 AADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 A + +G+ VA +W A E+ + Y+ A DVW+ G E+ Sbjct: 178 ADSITIKSGK-------VAIKWL-AIEI-FSKHCYTHASDVWAFGVTCWEI 219 >5VO2-A nrPDB Length = 300 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 92/204 (45%), Gaps = 35/204 (17%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLRE--IKILKHFKHENIITIFN 76 +G GA G V GE VA+KK+ R L+E IK L+ KH NIIT Sbjct: 20 VGSGAQGAVFLGRFH--GEEVAVKKV----------RDLKETDIKHLRKLKHPNIITFKG 67 Query: 77 I--QRPDSFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQTLRAVKVLHGSNV 133 + Q P +++ Q L+ V+ + + ++ + + + LH + Sbjct: 68 VCTQAP------CYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKI 121 Query: 134 IHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV 193 IHRDLK N+LI + +K+ DFG ++ + + + S + T + APEV Sbjct: 122 IHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMS-----------FAGTVAWMAPEV 170 Query: 194 MLTSAKYSRAMDVWSCGCILAELF 217 + + S +D+WS G +L EL Sbjct: 171 -IRNEPVSEKVDIWSFGVVLWELL 193 >4AT3-A nrPDB Length = 299 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 55/229 (24%), Positives = 91/229 (39%), Gaps = 47/229 (20%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTL------------REIKI 62 LK LGEGA+G V A DK L A++TL RE ++ Sbjct: 17 LKRELGEGAFGKVFLAE--------CYNLCPEQDKILVAVKTLKDASDNARKDFHREAEL 68 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-------------- 108 L + +HE+I+ + + E + + + + DL++ + Sbjct: 69 LTNLQHEHIVKFYGV----CVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTE 124 Query: 109 LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAAD 168 L+ + + Q + L + +HRDL N L+ N +K+ DFG++R D + D Sbjct: 125 LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR--DVYSTD 182 Query: 169 NSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 G + RW +M K++ DVWS G +L E+F Sbjct: 183 YYRVGGHT-----MLPIRWMPPESIMYR--KFTTESDVWSLGVVLWEIF 224 >3G0E-A nrPDB Length = 336 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 62/229 (27%), Positives = 87/229 (37%), Gaps = 31/229 (13%) Query: 19 LGEGAYGVVCSAT-----HKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF-KHENII 72 LG GA+G V AT VA+K ++P + E+K+L + H NI+ Sbjct: 54 LGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIV 113 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDH---------------IQYF 117 + Y + L R + + S + F Sbjct: 114 NLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSF 173 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 YQ + + L N IHRDL N+L+ K+CDFGLAR I + N G Sbjct: 174 SYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDS--NYVVKGNAR 231 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFPG 225 + +W APE + Y+ DVWS G L ELF L +PG Sbjct: 232 -----LPVKW-MAPESIFNCV-YTFESDVWSYGIFLWELFSLGSSPYPG 273 >2BUJ-A nrPDB Length = 317 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 92/217 (42%), Gaps = 22/217 (10%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKI---EPFDKPLFALRTLREIKILKHFKHENIITIF 75 LGEG + V G A+K+I E D+ RE + + F H NI+ + Sbjct: 37 LGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDRE----EAQREADMHRLFNHPNILRLV 92 Query: 76 NI---QRPDSFENFNEV-YIIQELMQTDLHRVI-STQMLSDDHIQYFIYQTLRAVKVLHG 130 +R E + + + + + ++ R+ L++D I + + R ++ +H Sbjct: 93 AYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHA 152 Query: 131 SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW--- 187 HRDLKP+N+L+ + D G A + E + Q + ++ A R Sbjct: 153 KGYAHRDLKPTNILLGDEGQPVLMDLGSM----NQACIHVEGSRQALTLQDWAAQRCTIS 208 Query: 188 YRAPEVMLTSAK--YSRAMDVWSCGCIL-AELFLRRP 221 YRAPE+ + DVWS GC+L A +F P Sbjct: 209 YRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGP 245 >4R7H-A nrPDB Length = 343 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 66/253 (26%), Positives = 103/253 (40%), Gaps = 52/253 (20%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHKPTGE-----IVAIKKIEPFDKPL 51 P ++ YN +F Q LG GA+G V AT G+ VA+K ++ Sbjct: 36 PTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD 95 Query: 52 FALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELMQ----TDLHRVIST 106 + E+KI+ H +HENI+ + + + V +I E + R + Sbjct: 96 EKEALMSELKIMSHLGQHENIVNLLG-----ACTHGGPVLVITEYCTYGDLLNFLRRKAE 150 Query: 107 QMLSDD---------------------HIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLI 145 ML + +F Q + + L N IHRD+ N+L+ Sbjct: 151 AMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL 210 Query: 146 NSNCDLKVCDFGLAR-IIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAM 204 + K+ DFGLAR I+++S N G + +W APE + S Y+ Sbjct: 211 TNGHVAKIGDFGLARDIMNDS---NYIVKGNAR-----LPVKWM-APESIFDSV-YTVQS 260 Query: 205 DVWSCGCILAELF 217 DVWS G +L E+F Sbjct: 261 DVWSYGILLWEIF 273 >2VD5-A nrPDB Length = 412 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 47/216 (21%), Positives = 100/216 (46%), Gaps = 11/216 (5%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDK-PLFALRTLREIKILKHFKHEN 70 DF++ ++G GA+ V K TG++ A+K + +D + RE + + Sbjct: 62 DFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRR 121 Query: 71 IITIFNIQRPDSFENFNEVYIIQEL-MQTDLHRVIS--TQMLSDDHIQYFIYQTLRAVKV 127 IT + +F++ N +Y++ E + DL ++S + + + ++++ + + A+ Sbjct: 122 WITQLHF----AFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDS 177 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 +H +HRD+KP N+L++ +++ DFG + AD + + G +Y++ Sbjct: 178 VHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKL---RADGTVRSLVAVGTPDYLSPEI 234 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 +A + Y D W+ G E+F + F Sbjct: 235 LQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF 270 >1U59-A nrPDB Length = 287 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 93/201 (46%), Gaps = 17/201 (8%) Query: 19 LGEGAYGVVCSATHKPTGEI--VAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFN 76 LG G +G V ++ + VAIK ++ + +RE +I+ + I+ + Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 77 Query: 77 IQRPDSFENFNEVYIIQELMQTDLHR--VISTQMLSDDHIQYFIYQTLRAVKVLHGSNVI 134 + + ++ + +++ LH+ V + + ++ ++Q +K L N + Sbjct: 78 VCQAEAL-----MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 132 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 HRDL N+L+ + K+ DFGL++ + AD+S T + +G +WY APE Sbjct: 133 HRDLAARNVLLVNRHYAKISDFGLSKAL---GADDSYYTARSAGKW---PLKWY-APEC- 184 Query: 195 LTSAKYSRAMDVWSCGCILAE 215 + K+S DVWS G + E Sbjct: 185 INFRKFSSRSDVWSYGVTMWE 205 >3PP0-A nrPDB Length = 338 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 52/222 (23%), Positives = 93/222 (41%), Gaps = 18/222 (8%) Query: 2 PKRIVYNISSDFQLKSL--LGEGAYGVVCSATHKPTGEIV----AIKKIEPFDKPLFALR 55 P + + I + +L+ + LG GA+G V P GE V AIK + P Sbjct: 6 PNQALLRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKE 65 Query: 56 TLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQ 115 L E ++ + + I + + ++ L+ D R ++ S D + Sbjct: 66 ILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLL--DHVRENRGRLGSQDLLN 123 Query: 116 YFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQ 175 + + Q + + L ++HRDL N+L+ S +K+ DFGLAR++D + G+ Sbjct: 124 WCM-QIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGK 182 Query: 176 QSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 V +W ++ +++ DVWS G + EL Sbjct: 183 -------VPIKWMALESIL--RRRFTHQSDVWSYGVTVWELM 215 >3VHK-A nrPDB Length = 368 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 38/118 (32%), Positives = 60/118 (50%), Gaps = 10/118 (8%) Query: 109 LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAAD 168 L+ +H+ + +Q + ++ L IHRDL N+L++ +K+CDFGLAR I Sbjct: 197 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI------ 250 Query: 169 NSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFPG 225 +P + G + +W APE + Y+ DVWS G +L E+F L +PG Sbjct: 251 YKDPDYVRKGDAR-LPLKWM-APETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPG 305 >5KMM-A nrPDB Length = 329 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 58/228 (25%), Positives = 97/228 (42%), Gaps = 37/228 (16%) Query: 12 DFQLKSLLGEGAYG-VVCSATHKPTGE----IVAIKKIEPFDKPLFALRTL-REIKILKH 65 D LK LGEGA+G V + H E +VA+K ++ + A + RE ++L Sbjct: 36 DIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASES--ARQDFQREAELLTM 93 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM----------------L 109 +H++I+ F + E + + + + DL+R + + L Sbjct: 94 LQHQHIVRFFGV----CTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPL 149 Query: 110 SDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADN 169 + Q + L G + +HRDL N L+ +K+ DFG++R D + D Sbjct: 150 GLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR--DIYSTDY 207 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 G+ + RW PE +L K++ DVWS G +L E+F Sbjct: 208 YRVGGR-----TMLPIRWM-PPESILYR-KFTTESDVWSFGVVLWEIF 248 >3PLS-A nrPDB Length = 298 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 93/218 (42%), Gaps = 37/218 (16%) Query: 18 LLGEGAYGVVCSATH------------KPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 ++G+G +GVV + K I ++++E F LRE +++ Sbjct: 28 VIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAF---------LREGLLMRG 78 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLS---DDHIQYFIYQTL 122 H N++ + I P E V ++ + DL + I + + D I + + Q Sbjct: 79 LNHPNVLALIGIMLPP--EGLPHV-LLPYMCHGDLLQFIRSPQRNPTVKDLISFGL-QVA 134 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLAR-IIDESAADNSEPTGQQSGMTE 181 R ++ L +HRDL N +++ + +KV DFGLAR I+D E Q Sbjct: 135 RGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDR------EYYSVQQHRHA 188 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLR 219 + +W L + +++ DVWS G +L EL R Sbjct: 189 RLPVKWTALES--LQTYRFTTKSDVWSFGVLLWELLTR 224 >5TE0-A nrPDB Length = 347 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 99/215 (46%), Gaps = 26/215 (12%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTL-REIKILKHFK-HENII--- 72 +L EG + +V G A+K++ F L+ REI+I++ H+NI+ Sbjct: 26 VLAEGGFAIV-FLVRTSNGMKCALKRM--FVNNEHDLQVCKREIQIMRDLSGHKNIVGYI 82 Query: 73 --TIFNIQRPDSFENFNEVYIIQELMQTD-----LHRVISTQMLSDDHIQYFIYQTLRAV 125 +I N+ D +E V I+ + + +++ + T ++ +Q F T AV Sbjct: 83 DSSINNVSSGDVWE----VLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFC-DTCEAV 137 Query: 126 KVLHGSN--VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 LH +IHRDLK N+L++ +CDFG A ++ +E + Sbjct: 138 ARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSA--TNKFQNPQTEGVNAVEDEIKKY 195 Query: 184 ATRWYRAPE-VMLTSAK-YSRAMDVWSCGCILAEL 216 T YRAPE V L S K + D+W+ GC+L +L Sbjct: 196 TTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKL 230 >3SOC-A nrPDB Length = 322 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 100/228 (43%), Gaps = 26/228 (11%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 +Y S QL + G +G V A + E VA+K DK + + E+ L Sbjct: 19 LYFQSMPLQLLEVKARGRFGCVWKA--QLLNEYVAVKIFPIQDKQ--SWQNEYEVYSLPG 74 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQY--------- 116 KHENI+ ++ + + + I + L + ++S + + + Sbjct: 75 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL 134 Query: 117 -FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQ 175 ++++ + +K H + HRD+K N+L+ +N + DFGLA + E+ + GQ Sbjct: 135 AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLA-LKFEAGKSAGDTHGQ 193 Query: 176 QSGMTEYVATRWYRAPEVMLTSAKYSR----AMDVWSCGCILAELFLR 219 V TR Y APEV+ + + R +D+++ G +L EL R Sbjct: 194 -------VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASR 234 >5AMN-A nrPDB Length = 299 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 88/219 (40%), Gaps = 31/219 (14%) Query: 15 LKSLLGEGAYGVVCSAT-----HKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 L LGEG +G V AT + VA+K ++ P L E +LK H Sbjct: 27 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHP 86 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI------------STQMLSDDHIQYF 117 ++I ++ D + +I E + R + L+ + F Sbjct: 87 HVIKLYGACSQD-----GPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISF 141 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 +Q + ++ L ++HRDL N+L+ +K+ DFGL+R + E + G+ Sbjct: 142 AWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGR-- 199 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 + +W A E + Y+ DVWS G +L E+ Sbjct: 200 -----IPVKWM-AIESLFDHI-YTTQSDVWSFGVLLWEI 231 >2OZO-A nrPDB Length = 613 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 48/201 (23%), Positives = 93/201 (46%), Gaps = 17/201 (8%) Query: 19 LGEGAYGVVCSATHKPTGEI--VAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFN 76 LG G +G V ++ + VAIK ++ + +RE +I+ + I+ + Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 Query: 77 IQRPDSFENFNEVYIIQELMQTDLHR--VISTQMLSDDHIQYFIYQTLRAVKVLHGSNVI 134 + + ++ + +++ LH+ V + + ++ ++Q +K L N + Sbjct: 404 VCQAEAL-----MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 HR+L N+L+ + K+ DFGL++ + AD+S T + +G +WY APE Sbjct: 459 HRNLAARNVLLVNRHYAKISDFGLSKAL---GADDSYYTARSAGKW---PLKWY-APEC- 510 Query: 195 LTSAKYSRAMDVWSCGCILAE 215 + K+S DVWS G + E Sbjct: 511 INFRKFSSRSDVWSYGVTMWE 531 >3C1X-A nrPDB Length = 373 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 56/223 (25%), Positives = 92/223 (41%), Gaps = 28/223 (12%) Query: 14 QLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIK-------ILKHF 66 ++G G +G V T KKI K L + + E+ I+K F Sbjct: 92 HFNEVIGRGHFGCVYHGTLLDNDG----KKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF 147 Query: 67 KHENIITIFNI-QRPDSFENFNEVYIIQELMQTDLHRVI--STQMLSDDHIQYFIYQTLR 123 H N++++ I R + + + ++ + DL I T + + F Q + Sbjct: 148 SHPNVLSLLGICLRSEG----SPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAK 203 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLAR-IIDESAADNSEPTGQQSGMTEY 182 +K L +HRDL N +++ +KV DFGLAR + D+ TG + Sbjct: 204 GMKFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAK------ 257 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLR-RPIFP 224 + +W L + K++ DVWS G +L EL R P +P Sbjct: 258 LPVKWMALES--LQTQKFTTKSDVWSFGVLLWELMTRGAPPYP 298 >4RT7-A nrPDB Length = 415 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 34/101 (33%), Positives = 50/101 (49%), Gaps = 9/101 (8%) Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 F YQ + ++ L + +HRDL N+L+ +K+CDFGLAR D + N G Sbjct: 248 FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLAR--DIMSDSNYVVRGNA 305 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 + +W APE + Y+ DVWS G +L E+F Sbjct: 306 R-----LPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIF 339 >3LZB-A nrPDB Length = 327 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 47/211 (22%), Positives = 88/211 (41%), Gaps = 16/211 (7%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIV----AIKKIEPFDKPLFALRTLREIKILKHF 66 ++F+ +LG GA+G V P GE V AIK++ P L E ++ Sbjct: 15 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 74 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 + ++ + I + + ++ L+ D R + S + + + Q + + Sbjct: 75 DNPHVCRLLGICLTSTVQLITQLMPFGCLL--DYVREHKDNIGSQYLLNWCV-QIAKGMN 131 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L ++HRDL N+L+ + +K+ DFGLA+++ + G+ V + Sbjct: 132 YLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGK-------VPIK 184 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 W ++ Y+ DVWS G + EL Sbjct: 185 WMALESIL--HRIYTHQSDVWSYGVTVWELM 213 >5GNK-A nrPDB Length = 297 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 49/214 (22%), Positives = 87/214 (40%), Gaps = 22/214 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIV----AIKKIEPFDKPLFALRTLREIKILKHF 66 ++F+ +LG GA+G V P GE V AIK++ P L E ++ Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 78 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFI---YQTLR 123 + ++ + I + V +I +LM + + QY + Q + Sbjct: 79 DNPHVCRLLGICLTST------VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 132 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 + L ++HRDL N+L+ + +K+ DFGLA+++ + G+ V Sbjct: 133 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGK-------V 185 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 +W ++ Y+ DVWS G + EL Sbjct: 186 PIKWMALESIL--HRIYTHQSDVWSYGVTVWELM 217 >5HLW-A nrPDB Length = 299 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 56/223 (25%), Positives = 92/223 (41%), Gaps = 28/223 (12%) Query: 14 QLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIK-------ILKHF 66 ++G G +G V T KKI K L + + E+ I+K F Sbjct: 23 HFNEVIGRGHFGCVYHGTLLDNDG----KKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF 78 Query: 67 KHENIITIFNI-QRPDSFENFNEVYIIQELMQTDLHRVI--STQMLSDDHIQYFIYQTLR 123 H N++++ I R + + + ++ + DL I T + + F Q + Sbjct: 79 SHPNVLSLLGICLRSEG----SPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAK 134 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLAR-IIDESAADNSEPTGQQSGMTEY 182 +K L +HRDL N +++ +KV DFGLAR + D+ TG + Sbjct: 135 GMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAK------ 188 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLR-RPIFP 224 + +W L + K++ DVWS G +L EL R P +P Sbjct: 189 LPVKWMALES--LQTQKFTTKSDVWSFGVLLWELMTRGAPPYP 229 >5U6B-A nrPDB Length = 307 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 87/228 (38%), Gaps = 30/228 (13%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEI--VAIKKIEPFDKPLFALRT-----LREIKILKHFK 67 L LGEG +G V I VA+K + K R+ L E +K F Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTM----KIAICTRSELEDFLSEAVCMKEFD 82 Query: 68 HENIITIFNIQ-RPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQY-------FI 118 H N++ + + + E+F +I M+ DLH + L D + F+ Sbjct: 83 HPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFM 142 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 ++ L IHRDL N ++N N + V DFGL++ I + G Sbjct: 143 ADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDY-------YRQG 195 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPI-FPG 225 + +W L Y+ DVWS G + E+ R +PG Sbjct: 196 RIAKMPVKWIAIES--LADRVYTSKSDVWSFGVTMWEIATRGQTPYPG 241 >3ZZW-A nrPDB Length = 289 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 49/197 (24%), Positives = 90/197 (45%), Gaps = 28/197 (14%) Query: 37 EIVAIKKIEPFDKPLFALRT--LREIKILKHFKHENIITIFNIQRPD----------SFE 84 + VAIK ++ DK LR E + +H N++ + + D S Sbjct: 40 QAVAIKTLK--DKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHG 97 Query: 85 NFNEVYIIQ----ELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKP 140 + +E +++ ++ TD R + + + D + + + Q ++ L +V+H+DL Sbjct: 98 DLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFV-HLVAQIAAGMEYLSSHHVVHKDLAT 156 Query: 141 SNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKY 200 N+L+ ++K+ D GL R + AAD + G + RW APE ++ K+ Sbjct: 157 RNVLVYDKLNVKISDLGLFREV--YAADYYKLLG-----NSLLPIRWM-APEAIMY-GKF 207 Query: 201 SRAMDVWSCGCILAELF 217 S D+WS G +L E+F Sbjct: 208 SIDSDIWSYGVVLWEVF 224 >1FVR-A nrPDB Length = 327 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/225 (24%), Positives = 90/225 (40%), Gaps = 34/225 (15%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTG--EIVAIKKIEPFDKPLFALRTLREIKIL-KHFK 67 +D + + ++GEG +G V A K G AIK+++ + E+++L K Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGH 84 Query: 68 HENIITIFNIQRPDSF----------ENFNEVYIIQELMQTDLHRVI---STQMLSDDHI 114 H NII + + N + +++TD I + LS + Sbjct: 85 HPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQL 144 Query: 115 QYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTG 174 +F R + L IHRDL N+L+ N K+ DFGL+R G Sbjct: 145 LHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR-------------G 191 Query: 175 QQSGMTEYVA---TRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 Q+ + + + RW L + Y+ DVWS G +L E+ Sbjct: 192 QEVYVKKTMGRLPVRWMAIES--LNYSVYTTNSDVWSYGVLLWEI 234 >3UIM-A nrPDB Length = 326 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 53/218 (24%), Positives = 96/218 (44%), Gaps = 15/218 (6%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 S +F K++LG G +G V G +VA+K+++ L+ E++++ H Sbjct: 29 SDNFSNKNILGRGGFGKVYKG-RLADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHR 87 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-LSDDHIQYFIYQTLRAVKVL 128 N++ + + Y+ + + L +Q L Q + R + L Sbjct: 88 NLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYL 147 Query: 129 HGS---NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 H +IHRD+K +N+L++ + V DFGLA+++D ++ T G ++ Sbjct: 148 HDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYK---DTHVTTAVRGTIGHI-- 202 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 APE L++ K S DV+ G +L EL + F Sbjct: 203 ----APEY-LSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >3Q4U-A nrPDB Length = 301 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 66/246 (26%), Positives = 103/246 (41%), Gaps = 44/246 (17%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 ++ D L +G+G YG V + + GE VA+K D+ + T E+ + Sbjct: 5 TVARDITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRET--ELYNTVMLR 60 Query: 68 HENIITIFN---IQRPDS--------FENFNEVYIIQELMQTD----LHRVIS-TQMLSD 111 HENI+ R S + +Y +L D L V+S L+ Sbjct: 61 HENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAH 120 Query: 112 DHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSE 171 HI+ F Q A+ HRDLK N+L+ N + D GLA + +S+ Sbjct: 121 LHIEIFGTQGKPAIA--------HRDLKSKNILVKKNGQCCIADLGLAVM-------HSQ 165 Query: 172 PTGQ-QSGMTEYVATRWYRAPEVMLTSAKYS-----RAMDVWSCGCILAELFLRRPIFPG 225 T Q G V T+ Y APEV+ + + + +D+W+ G +L E+ RR + G Sbjct: 166 STNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV-ARRMVSNG 224 Query: 226 --RDYR 229 DY+ Sbjct: 225 IVEDYK 230 >4H1J-A nrPDB Length = 293 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 56/223 (25%), Positives = 98/223 (43%), Gaps = 19/223 (8%) Query: 7 YNIS-SDFQLKSLLGEGAYGVVCSAT---HKPTGEIVAIKKIEPFDKPLFALRTLREIKI 62 Y I+ D L +LGEG +G V HK VA+K + + + E I Sbjct: 19 YGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVI 78 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTL 122 +K+ H +I+ + I + E+Y EL S ++L+ + + Q Sbjct: 79 MKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLT---LVLYSLQIC 135 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 +A+ L N +HRD+ N+L+ S +K+ DFGL+R I++ + T Sbjct: 136 KAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVT--------R 187 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL--FLRRPIF 223 + +W +PE + +++ A DVW + E+ F ++P F Sbjct: 188 LPIKW-MSPE-SINFRRFTTASDVWMFAVCMWEILSFGKQPFF 228 >5L2Q-C nrPDB Length = 320 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 49/206 (23%), Positives = 86/206 (41%), Gaps = 41/206 (19%) Query: 101 HRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCD-LKVCDFGLA 159 H VI + LS+ Y +R V+ LH N++HRDLK N+++N + + +F L Sbjct: 142 HYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLG 201 Query: 160 RIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLR 219 + + + Q G Y+ +P+V+ + D+W+ G +L + Sbjct: 202 KHL----VSEGDLLKDQRGSPAYI------SPDVLSGRPYRGKPSDMWALGVVLFTMLYG 251 Query: 220 RPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVN 279 + FP D Q L +A EY ++P RV+ Sbjct: 252 Q--FPFYDSIPQELF-----------------RKIKAAEY--TIPED---------GRVS 281 Query: 280 PKGIDLLQRMLVFDPAKRITAKEALE 305 + L++++LV DP +R+ A + LE Sbjct: 282 ENTVCLIRKLLVLDPQQRLAAADVLE 307 >3QGY-A nrPDB Length = 286 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 93/205 (45%), Gaps = 27/205 (13%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNI- 77 +G G +G+V + + VAIK I+ + + + E +++ H ++ ++ + Sbjct: 35 IGSGQFGLV-HLGYWLNKDKVAIKTIK--EGSMSEDDFIEEAEVMMKLSHPKLVQLYGVC 91 Query: 78 --QRPDSFENFNEVYIIQELMQTD-LHRVISTQ--MLSDDHIQYFIYQTLRAVKVLHGSN 132 Q P + ++ E M+ L + TQ + + + + + L + Sbjct: 92 LEQAP--------ICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEAC 143 Query: 133 VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPE 192 VIHRDL N L+ N +KV DFG+ R + + +S TG + +W +PE Sbjct: 144 VIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSS--TGTK------FPVKW-ASPE 194 Query: 193 VMLTSAKYSRAMDVWSCGCILAELF 217 V + ++YS DVWS G ++ E+F Sbjct: 195 V-FSFSRYSSKSDVWSFGVLMWEVF 218 >3M42-A nrPDB Length = 299 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 76/317 (23%), Positives = 126/317 (39%), Gaps = 87/317 (27%) Query: 9 ISSDFQLKS-LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 I D+++ S +LG G G V +K T E A+K ++ D P + RE+++ H++ Sbjct: 15 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--DCP----KARREVEL--HWR 66 Query: 68 HENIITIFNIQRPDSFENFNE-----VYIIQELMQTDLHRVI---STQMLSDDHIQYFIY 119 I I D +EN + +++ L +L I Q ++ + Sbjct: 67 ASQCPHIVRI--VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 124 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQ 176 A++ LH N+ HRD+KP NLL S N LK+ DFG A+ E TG+ Sbjct: 125 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----------ETTGE- 173 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 KY ++ D+WS G I+ L P F Y + L I Sbjct: 174 ----------------------KYDKSCDMWSLGVIMYILLCGYPPF----YSNHGLAI- 206 Query: 237 GIIGTPHSDNDLRCIE----SPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 +P +R + +P E + + M L++ +L Sbjct: 207 ----SPGMKTRIRMGQYEFPNPEWSEVSEEVKM-------------------LIRNLLKT 243 Query: 293 DPAKRITAKEALEHPYL 309 +P +R+T E + HP++ Sbjct: 244 EPTQRMTITEFMNHPWI 260 >3SXS-A nrPDB Length = 268 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 50/202 (24%), Positives = 85/202 (42%), Gaps = 21/202 (10%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 LG G +GVV K + VA+K I+ + + +E + + H ++ + + Sbjct: 16 LGSGQFGVVKLGKWKGQYD-VAVKMIK--EGSMSEDEFFQEAQTMMKLSHPKLVKFYGVC 72 Query: 79 RPDSFENFNEVYIIQELMQTD--LHRVIS-TQMLSDDHIQYFIYQTLRAVKVLHGSNVIH 135 + +YI+ E + L+ + S + L + Y + L IH Sbjct: 73 SKE-----YPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIH 127 Query: 136 RDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVML 195 RDL N L++ + +KV DFG+ R + + +S T +W APEV Sbjct: 128 RDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTK--------FPVKW-SAPEV-F 177 Query: 196 TSAKYSRAMDVWSCGCILAELF 217 KYS DVW+ G ++ E+F Sbjct: 178 HYFKYSSKSDVWAFGILMWEVF 199 >2QLU-A nrPDB Length = 314 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 56/226 (24%), Positives = 96/226 (42%), Gaps = 31/226 (13%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 QL + G +G V A + + VA+K DK + ++ REI KHEN Sbjct: 15 GSLQLLEIKARGRFGCVWKA--QLMNDFVAVKIFPLQDKQ--SWQSEREIFSTPGMKHEN 70 Query: 71 IITIFNIQRPDSFENFN-EVYIIQELM-QTDLHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 ++ ++ S N E+++I + L + +++ + + + R + L Sbjct: 71 LLQFIAAEKRGS--NLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYL 128 Query: 129 HGS-----------NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 H ++ HRD K N+L+ S+ + DFGLA + +P G Sbjct: 129 HEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEP-----GKPPGDTH 183 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSR----AMDVWSCGCILAELFLR 219 G V TR Y APEV+ + + R +D+++ G +L EL R Sbjct: 184 GQ---VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSR 226 >1LUF-A nrPDB Length = 343 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 58/226 (25%), Positives = 96/226 (42%), Gaps = 37/226 (16%) Query: 19 LGEGAYGVVCSAT------HKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +GEGA+G V A ++P +VA+K ++ RE ++ F + NI+ Sbjct: 55 IGEGAFGRVFQARAPGLLPYEPF-TMVAVKMLKEEASADMQADFQREAALMAEFDNPNIV 113 Query: 73 TIFNI---QRPD-------SFENFNEV------YIIQELMQTDLH---RVISTQM--LSD 111 + + +P ++ + NE + + L +DL RV S LS Sbjct: 114 KLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSC 173 Query: 112 DHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSE 171 Q + L +HRDL N L+ N +K+ DFGL+R I +AD + Sbjct: 174 AEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNI--YSADYYK 231 Query: 172 PTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 G + + RW PE + + +Y+ DVW+ G +L E+F Sbjct: 232 ADGNDA-----IPIRWM-PPESIFYN-RYTTESDVWAYGVVLWEIF 270 >5FM2-A nrPDB Length = 355 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 54/228 (23%), Positives = 91/228 (39%), Gaps = 35/228 (15%) Query: 15 LKSLLGEGAYGVVCSAT-----HKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 L LGEG +G V AT + VA+K ++ P L E +LK H Sbjct: 68 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHP 127 Query: 70 NIITIFNIQRPDS-------FENFNEVY-IIQELMQTD---LHRVISTQMLSDDH----- 113 ++I ++ D + + + ++E + L S S DH Sbjct: 128 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 187 Query: 114 -----IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAAD 168 + F +Q + ++ L ++HRDL N+L+ +K+ DFGL+R + E + Sbjct: 188 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 247 Query: 169 NSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 G+ + +W A E + Y+ DVWS G +L E+ Sbjct: 248 VKRSQGR-------IPVKWM-AIESLFDHI-YTTQSDVWSFGVLLWEI 286 >3MDY-A nrPDB Length = 337 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 61/249 (24%), Positives = 106/249 (42%), Gaps = 32/249 (12%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 +P + I+ Q+ +G+G YG V K GE VA+K ++ + RE Sbjct: 27 LPLLVQRTIAKQIQMVKQIGKGRYGEVWMG--KWRGEKVAVKVFFTTEEASW----FRET 80 Query: 61 KILKH--FKHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQMLSDDHIQYF 117 +I + +HENI+ F ++ ++Y+I + + L+ + + L + Sbjct: 81 EIYQTVLMRHENILG-FIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKL 139 Query: 118 IYQTLRAVKVLHGS--------NVIHRDLKPSNLLINSNCDLKVCDFGLA-RIIDESAAD 168 Y ++ + LH + HRDLK N+L+ N + D GLA + I ++ Sbjct: 140 AYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEV 199 Query: 169 NSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSR-----AMDVWSCGCILAELFLRRPIF 223 + P + V T+ Y PEV+ S + D++S G IL E+ RR + Sbjct: 200 DIPPNTR-------VGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEV-ARRCVS 251 Query: 224 PGRDYRHQL 232 G +QL Sbjct: 252 GGIVEEYQL 260 >4M69-B nrPDB Length = 283 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 41/179 (22%), Positives = 78/179 (43%), Gaps = 20/179 (11%) Query: 59 EIKILKHFKHENIITIFNI-----QRPDSFE---NFNEVYIIQELMQTDLHRVISTQMLS 110 EIK +K F NI+ IF I +P F + E+ ++EL+ + +S + L Sbjct: 58 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSL- 116 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 + + R + LH S +HR++ S+ L+ +K+ F L++ + + Sbjct: 117 ------LVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAK 170 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 ++S T YV+ + P + Y +++S G +L E+ + F G D + Sbjct: 171 STKAERSSSTIYVSPERLKNPFCL-----YDIKAEIYSFGIVLWEIATGKIPFEGCDSK 224 >4NFN-A nrPDB Length = 309 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 51/220 (23%), Positives = 90/220 (40%), Gaps = 25/220 (11%) Query: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 Y + +++ +G G +G + A T E VA+K +E +P L+ E+ +LK Sbjct: 17 YVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKM--EVAVLKKL 73 Query: 67 KHENIITIF-NIQRPDSFENFNEVYIIQELMQ---TDLHRVISTQMLSDDHIQYFIYQTL 122 + ++ + F R + F Y++ +L DL R + Q L Sbjct: 74 QGKDHVCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQIL 128 Query: 123 RAVKVLHGSNVIHRDLKPSNLLI----NSNCDLKVCDFGLARIIDESAADNSEPTGQQS- 177 +++ +H +HRD+KPSN + ++ + DFGLAR + D P Sbjct: 129 ESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF 188 Query: 178 -GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 G Y + ++ E+ R D+WS +L E Sbjct: 189 RGTVRYASVNAHKNREM-------GRHDDLWSLFYMLVEF 221 >5CEK-A nrPDB Length = 263 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 56/246 (22%), Positives = 103/246 (41%), Gaps = 47/246 (19%) Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQTLRAVK 126 H NI I + ++ + Y+ E D+H + S + L ++ Q + AV Sbjct: 60 HSNITGIVEVILGET-----KAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVA 114 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H S ++ DLK + ++ ++ R+ ES D G+ +++ Sbjct: 115 HCHQSAIVLGDLKLRKFVFSTEERTQL------RL--ESLEDTHIMKGEDDALSDKHGCP 166 Query: 187 WYRAPEVMLTSAKYS-RAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Y +PE++ T+ YS +A DVWS G +L L + R P D Sbjct: 167 AYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGR--------------------YPFHD 206 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 +D + S + R +P + ++PK L++ +L +P++R+TA E L Sbjct: 207 SDPSALFS-KIRRGQFCIPEH-----------ISPKARCLIRSLLRREPSERLTAPEILL 254 Query: 306 HPYLQT 311 HP+ ++ Sbjct: 255 HPWFES 260 >4LRM-A nrPDB Length = 334 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 49/217 (22%), Positives = 87/217 (40%), Gaps = 25/217 (11%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEI----VAIKKIEPFDKPLFALRTLREIKILKHF 66 ++F+ +LG GA+G V P GE VAIK++ P L E ++ Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 78 Query: 67 ---KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFI---YQ 120 + ++ + I + V +I +LM + + QY + Q Sbjct: 79 DNPGNPHVCRLLGICLTST------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ 132 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 + + L ++HRDL N+L+ + +K+ DFGLA+++ + G+ Sbjct: 133 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGK----- 187 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 V +W ++ Y+ DVWS G + EL Sbjct: 188 --VPIKWMALESIL--HRIYTHQSDVWSYGVTVWELM 220 >4BTK-A nrPDB Length = 337 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/220 (23%), Positives = 90/220 (40%), Gaps = 25/220 (11%) Query: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 Y + +++ +G G +G + A T E VA+K +E +P L+ E+ +LK Sbjct: 52 YVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKM--EVAVLKKL 108 Query: 67 KHENIITIF-NIQRPDSFENFNEVYIIQELMQ---TDLHRVISTQMLSDDHIQYFIYQTL 122 + ++ + F R + F Y++ +L DL R + Q L Sbjct: 109 QGKDHVCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQIL 163 Query: 123 RAVKVLHGSNVIHRDLKPSNLLI----NSNCDLKVCDFGLARIIDESAADNSEPTGQQS- 177 +++ +H +HRD+KPSN + ++ + DFGLAR + D P Sbjct: 164 ESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF 223 Query: 178 -GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 G Y + ++ E+ R D+WS +L E Sbjct: 224 RGTVRYASVNAHKNREM-------GRHDDLWSLFYMLVEF 256 >6DC0-A nrPDB Length = 292 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/246 (22%), Positives = 103/246 (41%), Gaps = 47/246 (19%) Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQTLRAVK 126 H NI I + ++ + Y+ E D+H + S + L ++ Q + AV Sbjct: 57 HSNITGIVEVILGET-----KAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVA 111 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H S ++ DLK + ++ ++ R+ ES D G+ +++ Sbjct: 112 HCHQSAIVLGDLKLRKFVFSTEERTQL------RL--ESLEDTHIMKGEDDALSDKHGCP 163 Query: 187 WYRAPEVMLTSAKYS-RAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Y +PE++ T+ YS +A DVWS G +L L + R P D Sbjct: 164 AYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGR--------------------YPFHD 203 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 +D + S + R +P + ++PK L++ +L +P++R+TA E L Sbjct: 204 SDPSALFS-KIRRGQFCIPEH-----------ISPKARCLIRSLLRREPSERLTAPEILL 251 Query: 306 HPYLQT 311 HP+ ++ Sbjct: 252 HPWFES 257 >5WNL-A nrPDB Length = 342 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 67/301 (22%), Positives = 127/301 (42%), Gaps = 49/301 (16%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK---KIEPFDKPLFALRTLREIKILKHF 66 + +F +G G +G V H +AIK + D+ L L E K ++ Sbjct: 19 AGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMEL--LEEAKKMEMA 76 Query: 67 KHENIITIFNI-QRPDSFENFNEVYIIQELMQT-DLHRVISTQMLSDDHIQYFIYQTLRA 124 K I+ ++ I Q P V ++ E M+T L ++++++ L D +++T Sbjct: 77 KFRYILPVYGICQEP--------VGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVG 128 Query: 125 VKVLHGSN--VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + LH + ++H +LKP+N+L++++ +K+ DFGLA+ N M Sbjct: 129 MNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKC-------NGMSHSHDLSMDGL 181 Query: 183 VATRWYRAPEVMLTSAK-YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 T Y PE + ++ + DV+S ++ + ++ F D ++ L ++ ++ Sbjct: 182 FGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFA--DEKNILHIMMKVV-- 237 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 + + LP P+ + PR I L+QR DP R T + Sbjct: 238 ---------------KGHRPELP-----PICRPRPRACASLIGLMQRCWHADPQVRPTFQ 277 Query: 302 E 302 E Sbjct: 278 E 278 >4M66-A nrPDB Length = 325 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 50/214 (23%), Positives = 101/214 (47%), Gaps = 18/214 (8%) Query: 14 QLKSL--LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 +LK L +G+G +GVV A H+ VA+K + + + E+K + + ++EN+ Sbjct: 21 ELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN-------SKKISWEVKAMVNLRNENV 73 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQMLSD-DHIQYFIYQTLRAVKVLH 129 + + + ++ + ++ M+ L ++ + + + + + + LH Sbjct: 74 LLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLH 133 Query: 130 GSN--VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 + ++HRDLKPSN+L++ K+ DFGL+ + +G SG + T Sbjct: 134 SLDPPLLHRDLKPSNILLDPELHAKLADFGLSTF----QGGSQSGSGSGSGSRDSGGTLA 189 Query: 188 YRAPEVML-TSAKYSRAMDVWSCGCILAELFLRR 220 Y PE++ + K S+A DV+S G ++ + R Sbjct: 190 YLDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >4BTF-A nrPDB Length = 469 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 41/179 (22%), Positives = 78/179 (43%), Gaps = 20/179 (11%) Query: 59 EIKILKHFKHENIITIFNI-----QRPDSFE---NFNEVYIIQELMQTDLHRVISTQMLS 110 EIK +K F NI+ IF I +P F + E+ ++EL+ + +S + L Sbjct: 244 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSL- 302 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 + + R + LH S +HR++ S+ L+ +K+ F L++ + + Sbjct: 303 ------LVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAK 356 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 ++S T YV+ + P + Y +++S G +L E+ + F G D + Sbjct: 357 STKAERSSSTIYVSPERLKNPFCL-----YDIKAEIYSFGIVLWEIATGKIPFEGCDSK 410 >3ZBF-A nrPDB Length = 322 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 60/224 (26%), Positives = 94/224 (41%), Gaps = 36/224 (16%) Query: 15 LKSLLGEGAYGVVCSAT-----HKPTGEI-VAIKKIEPFDKPLFALRTLREIKILKHFKH 68 L+ LLG GA+G V T +GEI VA+K ++ + L+E ++ F H Sbjct: 37 LRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNH 96 Query: 69 ENIITIFNIQRPDSFENFNE-VYIIQELMQ-TDLHRVISTQMLSDDH--------IQYFI 118 NI+ + NE YII ELM+ DL + ++ + + Sbjct: 97 PNILKQLGVCL------LNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLC 150 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLIN-----SNCDLKVCDFGLARIIDESAADNSEPT 173 + L + IHRDL N L++ S +K+ DFGLAR I ++ Sbjct: 151 VDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGE 210 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 G + RW APE ++ ++ DVWS G ++ E+ Sbjct: 211 G-------LLPVRWM-APESLMDGI-FTTQSDVWSFGILIWEIL 245 >4YFF-A nrPDB Length = 311 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 86/217 (39%), Gaps = 28/217 (12%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKK------IEPFDKPLFALRTLREIKILK 64 S+ + ++G G++G V + +IVAIK+ D +F RE+ IL Sbjct: 42 SEIEFHEIIGSGSFGKVYKG--RCRNKIVAIKRYRANTYCSKSDVDMFC----REVSILC 95 Query: 65 HFKHENIITIFN--IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTL 122 H +I + P F + YI + + LH ++L Sbjct: 96 QLNHPCVIQFVGACLNDPSQFAIVTQ-YISGGSLFSLLHE--QKRILDLQSKLIIAVDVA 152 Query: 123 RAVKVLHGSN--VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 + ++ LH +IHRDL N+L+ + V DFG +R + DN MT Sbjct: 153 KGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDN---------MT 203 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 + + APEV +Y+ DV+S L E+ Sbjct: 204 KQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEIL 240 >4Y12-A nrPDB Length = 375 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 48/220 (21%), Positives = 91/220 (41%), Gaps = 20/220 (9%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPT-GEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 ++ +++K + G G + A + G V +K + + E + L Sbjct: 117 VAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV 176 Query: 68 HENIITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 H +I+ IFN ++ D + +++ + L R ++ + I Y + + L A+ Sbjct: 177 HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLL-EILPALS 235 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH +++ DLKP N+++ LK+ D G I+ T Sbjct: 236 YLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINS--------------FGYLYGTP 280 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGR 226 ++APE++ T + A D+++ G LA L L P GR Sbjct: 281 GFQAPEIVRTGP--TVATDIYTVGRTLAALTLDLPTRNGR 318 >5O2B-A nrPDB Length = 285 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 96/213 (45%), Gaps = 39/213 (18%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR---EIKILKHFKHENIITIF 75 LG GA+ V T VA +++ D+ L R E ++LK +H NI+ + Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQ--DRKLTKAEQQRFKEEAEMLKGLQHPNIVRFY 81 Query: 76 NIQRPDSFENFNE----VYIIQELM-----QTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 DS+E+ + + ++ ELM +T L R +++ ++ + Q L+ ++ Sbjct: 82 -----DSWESILKGKKCIVLVTELMTSGTLKTYLKRF---KVMKPKVLRSWCRQILKGLQ 133 Query: 127 VLHGSN--VIHRDLKPSNLLINS-NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 LH +IHRDLK N+ I +K+ D GLA ++ S A + + Sbjct: 134 FLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKS------------VI 181 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 T + APE + Y ++DV++ G + E+ Sbjct: 182 GTPEFMAPE--MYEEHYDESVDVYAFGMCMLEM 212 >5U6C-A nrPDB Length = 315 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 54/224 (24%), Positives = 90/224 (40%), Gaps = 22/224 (9%) Query: 15 LKSLLGEGAYGVVCSATHKP---TGEIVAIKKIEPFDKPLFALRT-LREIKILKHFKHEN 70 L +LGEG +G V K T VA+K ++ + + L E +K F H N Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPN 99 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDD--HIQY-----FIYQTL 122 ++ + + S + + +I M+ DLH + L HI F+ Sbjct: 100 VMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIA 159 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 ++ L N +HRDL N ++ + + V DFGL++ I + D + G Sbjct: 160 LGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKI--YSGDY-----YRQGRIAK 212 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPI-FPG 225 + +W L Y+ DVW+ G + E+ R +PG Sbjct: 213 MPVKWIAIES--LADRVYTSKSDVWAFGVTMWEIATRGMTPYPG 254 >5O2C-A nrPDB Length = 380 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 96/213 (45%), Gaps = 39/213 (18%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR---EIKILKHFKHENIITIF 75 LG GA+ V T VA +++ D+ L R E ++LK +H NI+ + Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQ--DRKLTKAEQQRFKEEAEMLKGLQHPNIVRFY 90 Query: 76 NIQRPDSFENFNE----VYIIQELM-----QTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 DS+E+ + + ++ ELM +T L R +++ ++ + Q L+ ++ Sbjct: 91 -----DSWESILKGKKCIVLVTELMTSGTLKTYLKRF---KVMKPKVLRSWCRQILKGLQ 142 Query: 127 VLHGSN--VIHRDLKPSNLLINS-NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 LH +IHRDLK N+ I +K+ D GLA ++ S A + + Sbjct: 143 FLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKS------------VI 190 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 T + APE + Y ++DV++ G + E+ Sbjct: 191 GTPEFMAPE--MYEEHYDESVDVYAFGMCMLEM 221 >3QUP-A nrPDB Length = 323 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 53/229 (23%), Positives = 87/229 (37%), Gaps = 40/229 (17%) Query: 13 FQLKSLLGEGAYGVVCSATHKP-------------TGEIVAIKKIEPFDKPLFALRTLRE 59 F L +LG+G +G V A K +I+A IE F LRE Sbjct: 25 FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEF---------LRE 75 Query: 60 IKILKHFKHENIITIFNIQ-RPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDD----- 112 +K F H ++ + + R + +I M+ DLH + + ++ Sbjct: 76 AACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLP 135 Query: 113 --HIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 + F+ ++ L N IHRDL N ++ + + V DFGL+R I + D Sbjct: 136 LQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKI--YSGDY- 192 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLR 219 + G + +W L Y+ DVW+ G + E+ R Sbjct: 193 ----YRQGCASKLPVKWLALES--LADNLYTVHSDVWAFGVTMWEIMTR 235 >3MY0-A nrPDB Length = 305 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 62/243 (25%), Positives = 99/243 (40%), Gaps = 38/243 (15%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH-- 65 ++ L +G+G YG V GE VA+K D+ + RE +I Sbjct: 5 TVARQVALVECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSW----FRETEIYNTVL 58 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYFIYQTLRA 124 +H+NI+ F S + ++++I + L+ + Q L Sbjct: 59 LRHDNILG-FIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACG 117 Query: 125 VKVLH----GSN----VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 + LH G+ + HRD K N+L+ SN + D GLA ++ +D + Sbjct: 118 LAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLA-VMHSQGSDYLD----- 171 Query: 177 SGMTEYVATRWYRAPEVM--------LTSAKYSRAMDVWSCGCILAELFLRRPIFPG--R 226 G V T+ Y APEV+ S K++ D+W+ G +L E+ RR I G Sbjct: 172 IGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWT---DIWAFGLVLWEI-ARRTIVNGIVE 227 Query: 227 DYR 229 DYR Sbjct: 228 DYR 230 >2X7G-A nrPDB Length = 389 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 80/354 (22%), Positives = 126/354 (35%), Gaps = 64/354 (18%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN-------- 70 LG G + V VA+K ++ + L EIK+LK + + Sbjct: 39 LGWGHFSTVWLCWDMQGKRFVAMKVVKSAQH--YTETALDEIKLLKCVRESDPSDPNKDM 96 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST--QMLSDDHIQYFIYQTLRAVKVL 128 ++ + + + + + + L L +I + Q L ++ I Q L+ + L Sbjct: 97 VVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYL 156 Query: 129 HG-SNVIHRDLKPSNLLINSN--------------------------------CDLKV-- 153 H +IH D+KP N+L+ + DL V Sbjct: 157 HSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPAADLLVNP 216 Query: 154 CDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCIL 213 D A I AD TE + TR YR+ EV++ A YS D+WS C+ Sbjct: 217 LDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLI-GAGYSTPADIWSTACMA 275 Query: 214 AELFLRRPIF---PGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREY----------- 259 EL +F G DY I II S + +RE+ Sbjct: 276 FELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHIT 335 Query: 260 -IKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFDPAKRITAKEALEHPYLQT 311 +K ++ + +P + D L ML P KR +A E L HP+L + Sbjct: 336 KLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 389 >3I81-A nrPDB Length = 315 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 48/215 (22%), Positives = 88/215 (40%), Gaps = 31/215 (14%) Query: 19 LGEGAYGVVCSATHKPTGE-----IVAIKKIEPFDKPLFALRTLREIKILKHFKHENIIT 73 LG+G++G+V K + VAIK + + L E ++K F +++ Sbjct: 26 LGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVR 85 Query: 74 IFNIQRPDSFENFNEVYIIQELM-QTDLH---RVISTQMLSD--------DHIQYFIYQT 121 + + +I ELM + DL R + +M ++ + + Sbjct: 86 LLGV-----VSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEI 140 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 + L+ + +HRDL N ++ + +K+ DFG+ R I E+ + G Sbjct: 141 ADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDY-------YRKGGKG 193 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 + RW +PE L ++ DVWS G +L E+ Sbjct: 194 LLPVRWM-SPES-LKDGVFTTYSDVWSFGVVLWEI 226 >2PZI-A nrPDB Length = 681 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 48/220 (21%), Positives = 90/220 (40%), Gaps = 20/220 (9%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPT-GEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 ++ +++K + G G + A + G V +K + + E + L Sbjct: 78 VAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV 137 Query: 68 HENIITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 H +I+ IFN ++ D + +++ + L R ++ + I Y + + L A+ Sbjct: 138 HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLL-EILPALS 196 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH +++ DLKP N+++ LK+ D G I+ T Sbjct: 197 YLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINS--------------FGYLYGTP 241 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGR 226 ++APE++ T A D+++ G LA L L P GR Sbjct: 242 GFQAPEIVRTGPTV--ATDIYTVGRTLAALTLDLPTRNGR 279 >5AR8-A nrPDB Length = 326 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 54/225 (24%), Positives = 93/225 (41%), Gaps = 11/225 (4%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR--TLREIKILKHFKHENIITIFN 76 L GA G V SA H VA+K + L + R LRE +IL + I+ I Sbjct: 40 LSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILG 99 Query: 77 IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSN--VI 134 I F Y+ + LHR ++ +++ V LH ++ Sbjct: 100 ICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLL 159 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARI-IDESAADNSEPTGQQSGMTEYVATRWYRAPEV 193 H DLK N+L+++ +K+ DFGL++ + + S + + G Y+ Y + Sbjct: 160 HHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQK 219 Query: 194 MLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGI 238 S K+ D++S I E+ R+ P D + L +++ + Sbjct: 220 SRASIKH----DIYSYAVITWEVLSRKQ--PFEDVTNPLQIMYSV 258 >4XLV-A nrPDB Length = 328 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 47/215 (21%), Positives = 87/215 (40%), Gaps = 31/215 (14%) Query: 19 LGEGAYGVVCSATHKP--TGEI---VAIKKIEPFDKPLFALRTLREIKILKHFKHENIIT 73 LG+G++G+V + GE VA+K + + L E ++K F +++ Sbjct: 47 LGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVR 106 Query: 74 IFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDH--------IQYFIYQTLR- 123 + + ++ ELM DL + + ++ +Q I Sbjct: 107 LLGV-----VSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEI 161 Query: 124 --AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 + L+ +HRDL N ++ + +K+ DFG+ R I E+ + G Sbjct: 162 ADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDY-------YRKGGKG 214 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 + RW APE L ++ + D+WS G +L E+ Sbjct: 215 LLPVRWM-APES-LKDGVFTTSSDMWSFGVVLWEI 247 >3LMG-A nrPDB Length = 344 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 50/223 (22%), Positives = 89/223 (39%), Gaps = 24/223 (10%) Query: 4 RIVYNISSDFQLKSL--LGEGAYGVVCSATHKPTGEI----VAIKKIEPFDKPLFALRTL 57 +++ I + +L+ L LG G +G V P GE V IK IE Sbjct: 22 KVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVT 81 Query: 58 REIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHR-VISTQMLSDDHIQ 115 + + H +I+ + + S + + + L+ HR + Q+L + Sbjct: 82 DHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLN---- 137 Query: 116 YFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQ 175 + Q + + L ++HR+L N+L+ S ++V DFG+A ++ P + Sbjct: 138 -WGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLL--------PPDDK 188 Query: 176 QSGMTEY-VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 Q +E +W + KY+ DVWS G + EL Sbjct: 189 QLLYSEAKTPIKWMALESIHF--GKYTHQSDVWSYGVTVWELM 229 >1PY5-A nrPDB Length = 326 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 56/239 (23%), Positives = 103/239 (43%), Gaps = 31/239 (12%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 +P + I+ L+ +G+G +G V K GE VA+K ++ + RE Sbjct: 19 LPLLVQRTIARTIVLQESIGKGRFGEVWRG--KWRGEEVAVKIFSSREERSW----FREA 72 Query: 61 KILKH--FKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYF 117 +I + +HENI+ D+ + +++++ + + L ++ ++ + + Sbjct: 73 EIYQTVMLRHENILGFIAADNKDN-GTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKL 131 Query: 118 IYQTLRAVKVLH----GSN----VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADN 169 T + LH G+ + HRDLK N+L+ N + D GLA + +SA D Sbjct: 132 ALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLA-VRHDSATDT 190 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTS------AKYSRAMDVWSCGCILAELFLRRPI 222 + V T+ Y APEV+ S + RA D+++ G + E+ R I Sbjct: 191 IDIAPNHR-----VGTKRYMAPEVLDDSINMKHFESFKRA-DIYAMGLVFWEIARRCSI 243 >5CLR-A nrPDB Length = 451 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 42/156 (26%), Positives = 68/156 (43%), Gaps = 27/156 (17%) Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 VK H +IHRDLKP N++++++ + DFG S++ + EP G Y+A Sbjct: 189 VKQFHELGLIHRDLKPGNIMLDADMQCHLVDFG-------SSSSDKEPKPASWGTASYLA 241 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF--LRRPIFPGRDY----RHQLLL---- 234 + + +S+ D+++ L ELF R+ F D +H +LL Sbjct: 242 PELNAQEDFI----AFSQVSDLFALAYSLDELFNPFRQVKFAKVDIGIKNKHLVLLHAEI 297 Query: 235 ---IFGIIGTPHSDNDL---RCIESPRAREYIKSLP 264 I G++ S L R ++ R E KS P Sbjct: 298 EACITGLMSNETSVRTLYFSRILQLQRVPESFKSRP 333 >2QKW-B nrPDB Length = 321 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 49/217 (22%), Positives = 95/217 (43%), Gaps = 22/217 (10%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 +++F K L+G G +G V + G VA+K+ P + EI+ L +H Sbjct: 38 TNNFDHKFLIGHGVFGKVYKGVLRD-GAKVALKRRTP-ESSQGIEEFETEIETLSFCRHP 95 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQT-DLHR-----VISTQMLSDDHIQYFIYQTLR 123 +++++ + NE+ +I + M+ +L R + T +S + R Sbjct: 96 HLVSLIGF-----CDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAAR 150 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 + LH +IHRD+K N+L++ N K+ DFG+++ + D + + G Y+ Sbjct: 151 GLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISK--KGTELDQTHLSTVVKGTLGYI 208 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRR 220 ++ + + DV+S G +L E+ R Sbjct: 209 DPEYF-------IKGRLTEKSDVYSFGVVLFEVLCAR 238 >3AOX-A nrPDB Length = 344 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 51/218 (23%), Positives = 85/218 (38%), Gaps = 35/218 (16%) Query: 19 LGEGAYG-----VVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIIT 73 LG GA+G V + P+ VA+K + L L E I+ F H+NI+ Sbjct: 55 LGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVR 114 Query: 74 IFNIQRPDSFENFNEVYIIQELMQTDLHRVI-----------STQMLSDDHIQYFIYQTL 122 + S ++ +++ + DL + S ML H+ I Sbjct: 115 CIGV----SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIAC-- 168 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGM 179 + L ++ IHRD+ N L+ K+ DFG+AR I ++ + G Sbjct: 169 -GCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASY-------YRKGG 220 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 + +W PE + ++ D WS G +L E+F Sbjct: 221 CAMLPVKWM-PPEAFMEGI-FTSKTDTWSFGVLLWEIF 256 >4PWN-A nrPDB Length = 274 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 94/213 (44%), Gaps = 38/213 (17%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR---EIKILKHFKHENIITIF 75 +G G++ V T V + E D+ L R E ++LK +H NI+ + Sbjct: 18 IGRGSFKTVYKGLDTET--TVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFY 75 Query: 76 NIQRPDSFENFNE----VYIIQELM-----QTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 DS+E+ + + ++ ELM +T L R +++ ++ + Q L+ ++ Sbjct: 76 -----DSWESTVKGKKCIVLVTELMTSGTLKTYLKRF---KVMKIKVLRSWCRQILKGLQ 127 Query: 127 VLHGSN--VIHRDLKPSNLLINS-NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 LH +IHRDLK N+ I +K+ D GLA + ++ S + Sbjct: 128 FLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKS-----------VI 176 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 T + APE + KY ++DV++ G + E+ Sbjct: 177 GTPEFMAPE--MYEEKYDESVDVYAFGMCMLEM 207 >4WUA-A nrPDB Length = 401 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 76/356 (21%), Positives = 130/356 (36%), Gaps = 66/356 (18%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH--------EN 70 LG G + V + + VA+K ++ + + L EI++LK ++ E Sbjct: 49 LGWGHFSTVWLSWDIQGKKFVAMKVVKSAEH--YTETALDEIRLLKSVRNSDPNDPNREM 106 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST--QMLSDDHIQYFIYQTLRAVKVL 128 ++ + + + + + + L L +I + Q L ++ I Q L+ + L Sbjct: 107 VVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYL 166 Query: 129 HGS-NVIHRDLKPSNLLINSN-----------------------------CDLKVCDFGL 158 H +IH D+KP N+L++ N +F + Sbjct: 167 HTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPATAGNFLV 226 Query: 159 -------ARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGC 211 A + AD TE + TR YR+ EV++ S Y+ D+WS C Sbjct: 227 NPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSG-YNTPADIWSTAC 285 Query: 212 ILAELFLRRPIFP-------GRDYRHQLLLI--FG------IIGTPHSDNDLRCIESPRA 256 + EL +F RD H L+I G I+ +S + Sbjct: 286 MAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKH 345 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFDPAKRITAKEALEHPYLQT 311 +K ++ + + + G D L ML P KR TA E L HP+L + Sbjct: 346 ITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS 401 >4JRN-A nrPDB Length = 372 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 61/272 (22%), Positives = 102/272 (37%), Gaps = 57/272 (20%) Query: 1 MPKRIVYNISSDFQL---KSLLGEGAYGVVCSATHKPTGEIVAIK----KIEPFDKPLFA 53 +PKR V + + + + LG G + V AT T E +A+K + EP D+ + Sbjct: 55 VPKRFVSVTTGETRTLVRGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLD 114 Query: 54 LR----TLREIKILKHFKHENIITIFNI--------QRPDSFENFNEV--------YIIQ 93 L+ R + K K F + +P S E + +++ Sbjct: 115 LQRESSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLM 174 Query: 94 ELMQTDLHRVISTQMLSDDHIQ----------YFIYQTLRAVKVLHGSNVIHRDLKPSNL 143 + D+ +VIS + D + Y Q ++ V + ++H D+KP+N Sbjct: 175 MRAEADMSKVIS-WVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANF 233 Query: 144 LINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPE--VMLTSAKYS 201 L+ + L + DFG RI +NS + + T Y PE T Y+ Sbjct: 234 LLLKDGRLFLGDFGTYRI------NNS--------VGRAIGTPGYEPPERPFQATGITYT 279 Query: 202 RAMDVWSCGCILAELFLRRPIFPGR---DYRH 230 D W G L ++ + P DY H Sbjct: 280 FPTDAWQLGITLYCIWCKERPTPADGIWDYLH 311 >2WTK-B nrPDB Length = 373 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 94/213 (44%), Gaps = 18/213 (8%) Query: 13 FQLKSLLGEGAYGV--VCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKH 68 ++L +++G+G + V A +KPTGE V +++I E + E+ + K F H Sbjct: 11 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQ-GELHVSKLFNH 69 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHR-VISTQM---LSDDHIQYFIYQTLRA 124 NI+ +F NE++++ M + +I T +++ I Y + L+A Sbjct: 70 PNIVPY-----RATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKA 124 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + +H +HR +K S++LI + D KV GL + + + Sbjct: 125 LDYIHHMGYVHRSVKASHILI--SVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKV 182 Query: 185 TRWYRAPEVMLTSAK-YSRAMDVWSCGCILAEL 216 W +PEV+ + + Y D++S G EL Sbjct: 183 LPWL-SPEVLQQNLQGYDAKSDIYSVGITACEL 214 >5J0A-A nrPDB Length = 300 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 46/191 (24%), Positives = 85/191 (44%), Gaps = 24/191 (12%) Query: 40 AIKKIEPFD----KPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQEL 95 A+KKI P + ++ R + E KILK H NI+ R + N + + E Sbjct: 41 AVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGY----RAFTEANDGSLCLAMEY 96 Query: 96 M-QTDLHRVISTQMLSDDH------IQYFIYQTLRAVKVLHGSN-VIHRDLKPSNLLINS 147 + L+ +I + + I R +K LH ++H D+K SN++I Sbjct: 97 GGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKG 156 Query: 148 NCD-LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDV 206 + + +K+CD G++ +DE N E T ++ Y+ T ++ E + + + D+ Sbjct: 157 DFETIKICDVGVSLPLDE----NMEVTDPEAC---YIGTEPWKPKEAVEENGVITDKADI 209 Query: 207 WSCGCILAELF 217 ++ G L E+ Sbjct: 210 FAFGLTLWEMM 220 >3SV0-A nrPDB Length = 483 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 51/216 (23%), Positives = 95/216 (43%), Gaps = 17/216 (7%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 + + F+L +G G++G + T+ T E VAIK K L + +IL+ Sbjct: 5 VGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIYRILQGGTG 64 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS--TQMLSDDHIQYFIYQTLRAVK 126 + F ++ ++N ++ +L+ L + + ++ LS + Q + V+ Sbjct: 65 IPNVRWFGVE-----GDYN--VLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVE 117 Query: 127 VLHGSNVIHRDLKPSNLLIN---SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 +H + +HRD+KP N L+ + + DFGLA+ +++ P + +T Sbjct: 118 FVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLT--- 174 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLR 219 T Y + L + SR D+ S G +L FLR Sbjct: 175 GTARYASVNTHL-GIEQSRRDDLESLGYVLM-YFLR 208 >5X1R-A nrPDB Length = 302 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 49/235 (20%), Positives = 87/235 (37%), Gaps = 38/235 (16%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF------DKPLFALRTLR------ 58 ++F+++ +GEG +G+V A +AIK+ P D LR R Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 59 --------EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ--M 108 E ++L F H ++ + EN Q T L + + Q Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFWE----ENGTAYMGTQFYSGTTLKNLQAQQPEK 136 Query: 109 LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAAD 168 + + I+ + A+ +H +HRD+ N+ I + + DFG AR Sbjct: 137 IDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSAR-------- 188 Query: 169 NSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRA--MDVWSCGCILAELFLRRP 221 + G S TE V + E ++ + D+++ G +L L + P Sbjct: 189 --KEIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSP 241 >5FQD-C nrPDB Length = 341 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 52/222 (23%), Positives = 101/222 (45%), Gaps = 20/222 (9%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK-KIEPFDKPLFALRTLREIKILKHFK 67 + ++L +G G++G + A + GE VA+K + + P + L E K+ K Sbjct: 17 VGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHP----QLLYESKLYKIL- 71 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS--TQMLSDDHIQYFIYQTLRAV 125 + + I +I+ +++N ++ +L+ L + + ++ + + Q + + Sbjct: 72 -QGGVGIPHIRWYGQEKDYN--VLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRI 128 Query: 126 KVLHGSNVIHRDLKPSNLL--INSNCD-LKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + +H N IHRD+KP N L I +C+ L + DFGLA+ ++ P + +T Sbjct: 129 EYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLT-- 186 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFP 224 T Y + L + SR D+ S G +L ++ R P Sbjct: 187 -GTARYASINAHL-GIEQSRRDDMESLGYVL--MYFNRTSLP 224 >4TN6-A nrPDB Length = 318 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 50/211 (23%), Positives = 91/211 (43%), Gaps = 18/211 (8%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK-KIEPFDKPLFALRTLREIKILKHFK 67 + + ++L +G G++G + T GE VAIK + P + E KI K Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHI----ESKIYKMM- 59 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS--TQMLSDDHIQYFIYQTLRAV 125 + + I I+ + ++N ++ EL+ L + + ++ S + Q + + Sbjct: 60 -QGGVGIPTIRWCGAEGDYN--VMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRI 116 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + +H N IHRD+KP N L+ + + DFGLA+ ++ P + +T Sbjct: 117 EYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLT-- 174 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCIL 213 T Y + L + SR D+ S G +L Sbjct: 175 -GTARYASINTHL-GIEQSRRDDLESLGYVL 203 >2Y4I-B nrPDB Length = 319 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 51/214 (23%), Positives = 96/214 (44%), Gaps = 16/214 (7%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTL-REIKILKHFKHENI 71 ++ L+G+G +G V + GE VAI+ I+ L+ RE+ + +HEN+ Sbjct: 35 LEIGELIGKGRFGQVYHG--RWHGE-VAIRLIDIERDNEDQLKAFKREVMAYRQTRHENV 91 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI--STQMLSDDHIQYFIYQTLRAVKVL 128 + + + + II L + L+ V+ + +L + + + ++ + L Sbjct: 92 VLFMG-----ACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYL 146 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQ-QSGMTEYVATRW 187 H ++H+DLK N+ + N + + DFGL I A E + Q+G ++A Sbjct: 147 HAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEI 205 Query: 188 YR--APEVMLTSAKYSRAMDVWSCGCILAELFLR 219 R +P+ +S+ DV++ G I EL R Sbjct: 206 IRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAR 239 >4L68-A nrPDB Length = 340 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 33/104 (31%), Positives = 52/104 (50%), Gaps = 13/104 (12%) Query: 133 VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPE 192 ++H+++ S +LI+ + D ++ D GLAR++ S DN+E S MT + Y APE Sbjct: 160 ILHQNICSSVILIDEDFDARIIDSGLARLMVPS--DNNES----SFMTGDLGEFGYVAPE 213 Query: 193 ---VMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLL 233 ML S K DV+ G +L EL G ++ L+ Sbjct: 214 YSTTMLASLK----GDVYGLGVVLLELATGLKAVGGEGFKGSLV 253 >5X18-A nrPDB Length = 295 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/168 (24%), Positives = 76/168 (45%), Gaps = 40/168 (23%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR-TLREIKILK------- 64 +++ +GEG++GV+ T+ G VAI K EP LR + KIL Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAI-KFEPRKTEAPQLRDEYKTYKILNGTPNIPY 67 Query: 65 --HFKHENI--ITIFNIQRP---DSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYF 117 +F E + I + ++ P D F+ + ++ ++Q ++ QM++ Sbjct: 68 AYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQ------VAVQMIT------- 114 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLIN-----SNCDLKVCDFGLAR 160 ++ LH ++I+RD+KP N LI ++ + DFG+A+ Sbjct: 115 ------LIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAK 156 >3G2F-A nrPDB Length = 336 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/180 (24%), Positives = 78/180 (43%), Gaps = 16/180 (8%) Query: 133 VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPE 192 + HRDL N+L+ ++ + DFGL+ + + P + + V T Y APE Sbjct: 141 ISHRDLNSRNVLVKNDGTCVISDFGLSMRL--TGNRLVRPGEEDNAAISEVGTIRYMAPE 198 Query: 193 VMLTSAKYS------RAMDVWSCGCILAELFLR-RPIFPGRDYRHQLLLIFGIIGTPHSD 245 V+ + + +D+++ G I E+F+R +FPG + +G + Sbjct: 199 VLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTF 258 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 D++ + S RE K P +P A E + K + ++ D R+TA+ A E Sbjct: 259 EDMQVLVS---RE--KQRPKFPEAWKENSLAVRSLK--ETIEDCWDQDAEARLTAQCAEE 311 >1CSN-A nrPDB Length = 298 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 45/188 (23%), Positives = 83/188 (44%), Gaps = 21/188 (11%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR-TLREIKILKHFK 67 + +++ +GEG++GV+ T+ + VAIK EP LR R K+L Sbjct: 8 VGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIK-FEPRRSDAPQLRDEYRTYKLLAGCT 66 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS--TQMLSDDHIQYFIYQTLRAV 125 I ++ + E + V +I +L+ L ++ + S + Q L V Sbjct: 67 --GIPNVYYFGQ----EGLHNVLVI-DLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARV 119 Query: 126 KVLHGSNVIHRDLKPSNLLI------NSNCDLKVCDFGLARIIDESAADNSEPTGQQ--- 176 + +H ++++RD+KP N LI N+N + V DFG+ + + P ++ Sbjct: 120 QSIHEKSLVYRDIKPDNFLIGRPNSKNANM-IYVVDFGMVKFYRDPVTKQHIPYREKKNL 178 Query: 177 SGMTEYVA 184 SG Y++ Sbjct: 179 SGTARYMS 186 >5VC6-A nrPDB Length = 289 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 31/144 (21%), Positives = 66/144 (45%), Gaps = 11/144 (7%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREI---KILKH 65 +++F +G G +G V + G I AIK+ + P + LRE+ +L Sbjct: 10 TTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLG- 68 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQ---TDLHRVISTQMLSDDHIQYFIYQTL 122 +H +++ F+ D Y + ++ +R++S + ++ + Q Sbjct: 69 -QHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMS--YFKEAELKDLLLQVG 125 Query: 123 RAVKVLHGSNVIHRDLKPSNLLIN 146 R ++ +H +++H D+KPSN+ I+ Sbjct: 126 RGLRYIHSMSLVHMDIKPSNIFIS 149 >4MWI-A nrPDB Length = 294 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 39/170 (22%), Positives = 71/170 (41%), Gaps = 24/170 (14%) Query: 58 REIKILKHFKHENIITIFNI-----QRPDSFE---NFNEVYIIQELMQTDLHRVISTQML 109 +EIK +K F+ NI+ IF I P F + E+ ++EL+ + + +M+ Sbjct: 72 KEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMV 131 Query: 110 SDDHIQYFIYQTLRAVKVLHGSNV--IHRDLKPSNLLINSNCDLKVCDFGLARIIDESAA 167 + R + LH S +H ++ SN L+ +K+ F L + Sbjct: 132 -------LVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRK------T 178 Query: 168 DNSEPTGQQSGMTEYVATRWYRAP-EVMLTSAKYSRAMDVWSCGCILAEL 216 S G T+ V + Y +P E+ +Y +++S G +L E+ Sbjct: 179 QTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEI 228 >4XHL-A nrPDB Length = 394 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 48/219 (21%), Positives = 87/219 (39%), Gaps = 34/219 (15%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK---------KIEPFDKPLFALRTLRE 59 + F++ +G G++G + T+ +GE VAI+ +++ + L Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSGGVG 64 Query: 60 IKILKHFKHENIIT--IFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYF 117 I ++ F E + ++ P + FN HR S + + +Q F Sbjct: 65 IPFIRWFGREGEYNAMVIDLLGPSLEDLFNYC-----------HRRFSFKTVIMLALQMF 113 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLIN---SNCDLKVCDFGLARIIDESAADNSEPTG 174 ++ +HG + IHRD+KP N L+ + V DFGL++ + P Sbjct: 114 C-----RIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYR 168 Query: 175 QQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCIL 213 + +T T Y + L + SR D+ S G +L Sbjct: 169 ENKSLT---GTARYASVNTHL-GIEQSRRDDLESLGYVL 203 >2CMW-A nrPDB Length = 310 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 18/46 (39%), Positives = 27/46 (58%), Gaps = 5/46 (10%) Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLK-----VCDFGLAR 160 Q L ++ +H N+I+RD+KP N LI + K + DFGLA+ Sbjct: 105 QLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAK 150 >3ENH-A nrPDB Length = 540 Score = 37.0 bits (84), Expect = 0.013, Method: Compositional matrix adjust. Identities = 36/126 (28%), Positives = 54/126 (42%), Gaps = 17/126 (13%) Query: 45 EPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFE-NFNEVYIIQELMQTDLHRV 103 E D+ + RT RE + L K F I P F+ + + I+ + L + Sbjct: 375 ERLDENIRKSRTAREARYLALVKD------FGIPAPYIFDVDLDNKRIMMSYINGKLAKD 428 Query: 104 ISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARI-- 161 + L Y+ V LH ++VIH DL SN + + DL + DFGL +I Sbjct: 429 VIEDNLD------IAYKIGEIVGKLHKNDVIHNDLTTSNFIFDK--DLYIIDFGLGKISN 480 Query: 162 IDESAA 167 +DE A Sbjct: 481 LDEDKA 486 >4XHH-A nrPDB Length = 403 Score = 36.6 bits (83), Expect = 0.019, Method: Compositional matrix adjust. Identities = 28/97 (28%), Positives = 44/97 (45%), Gaps = 7/97 (7%) Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLIN---SNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 Q + V+ +HG + IHRD+KP N L+ + V DFGL++ + P + Sbjct: 111 QMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYREN 170 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCIL 213 +T T Y + L + SR D+ S G +L Sbjct: 171 KSLT---GTARYASVNTHL-GIEQSRRDDLESLGYML 203 >6G4J-A nrPDB Length = 315 Score = 35.8 bits (81), Expect = 0.028, Method: Compositional matrix adjust. Identities = 35/144 (24%), Positives = 64/144 (44%), Gaps = 22/144 (15%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 + L+ LG+GA G+V A + + VA+K + +L E+ +LK F + Sbjct: 28 YTLRKQLGKGANGIVYLA--ETSDGHVALKVSDD------SLSITSEVNVLKSFSKAQSV 79 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHRV------ISTQMLSDDHIQY---FIYQTLR 123 T+ SF + ++ YI + + + + + +SD ++ + Q L Sbjct: 80 TM-----GPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLS 134 Query: 124 AVKVLHGSNVIHRDLKPSNLLINS 147 ++ VLH I DLKP NL++ Sbjct: 135 SLSVLHQQGWIFGDLKPDNLIVTG 158 >4OAU-C nrPDB Length = 699 Score = 35.8 bits (81), Expect = 0.032, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 3/105 (2%) Query: 55 RTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQT--DLHRVISTQMLSDD 112 R RE+ L+ + + + F F V + ++ ++ D+HR + D+ Sbjct: 380 RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 439 Query: 113 HIQYFIYQTLRAVKVLHGS-NVIHRDLKPSNLLINSNCDLKVCDF 156 + + +AV+ LH S H+DL+P N+LI+S + DF Sbjct: 440 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 484 >4O1O-A nrPDB Length = 717 Score = 35.0 bits (79), Expect = 0.052, Method: Compositional matrix adjust. Identities = 26/108 (24%), Positives = 51/108 (47%), Gaps = 6/108 (5%) Query: 53 ALRTLREIKILKHFK-HENIITIFNIQRPDSFENFNEV---YIIQELMQTDLHRVISTQM 108 + R +E+ L+ + ++N++T + + S + Y +QE + HR + Sbjct: 381 STRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLAN--HRGDAVPN 438 Query: 109 LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDF 156 D+ + + +A+ LH S H+DL+P N+LI+S + DF Sbjct: 439 EEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF 486 >4IX6-A nrPDB Length = 350 Score = 34.7 bits (78), Expect = 0.064, Method: Compositional matrix adjust. Identities = 35/139 (25%), Positives = 58/139 (41%), Gaps = 34/139 (24%) Query: 104 ISTQMLSDDHIQYFIYQT-----LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGL 158 ++T M D + + + L ++ LH V+HRD+KP+NL+ D G+ Sbjct: 130 LATAMACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEK------DGGV 183 Query: 159 ARIIDESAADNSEPTGQQSGMTEYVAT-----RWYRAPEVML-----------TSAKYSR 202 ++ID AA P + + Y R+ +A E+ L +AK Sbjct: 184 LKLIDLGAAALCLPLPET--LNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWE 241 Query: 203 A-----MDVWSCGCILAEL 216 A D WS GC++ +L Sbjct: 242 AHKPDRFDSWSAGCVMLQL 260 >4NT4-A nrPDB Length = 312 Score = 33.9 bits (76), Expect = 0.097, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 26/46 (56%), Gaps = 5/46 (10%) Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCD-----LKVCDFGLAR 160 Q L ++ +H ++I+RD+KP N LI + + DFGLA+ Sbjct: 122 QLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAK 167 >5UU1-A nrPDB Length = 324 Score = 33.1 bits (74), Expect = 0.19, Method: Compositional matrix adjust. Identities = 46/233 (19%), Positives = 96/233 (41%), Gaps = 20/233 (8%) Query: 10 SSDFQLKSLLGEGAYGVVCSA--THKPTGEIVAIKKIE-PFDKPLFA-----LRTLREIK 61 + + L +G G +G++ A T+KP + + K+E + PLF+ R ++ Sbjct: 15 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDC 74 Query: 62 ILKHFKHENI----ITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ-MLSDDHIQY 116 I K + + + I +F F+ + +++ E + DL ++ + Sbjct: 75 IKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQ 134 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLIN-SNCD-LKVCDFGLARIIDESAAD---NSE 171 + L ++ +H + +H D+K +NLL+ N D + + D+GL+ + Sbjct: 135 LGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQEN 194 Query: 172 PTGQQSGMTEYVATRWYRAPEVMLTS--AKYSRAMDVWSCGCILAELFLRRPI 222 P +G E+ + ++ + S M W CG + E L+ P+ Sbjct: 195 PRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPV 247 >5DMZ-A nrPDB Length = 365 Score = 32.7 bits (73), Expect = 0.22, Method: Compositional matrix adjust. Identities = 34/154 (22%), Positives = 63/154 (40%), Gaps = 19/154 (12%) Query: 11 SDFQLKS-------LLGEGAYGVVCSATHKPTGEIVAIKKIEPF----DKPLFALRTLRE 59 ++FQL S LLGEGA+ V AT G++ K + F KP Sbjct: 58 TEFQLGSKLVYVHHLLGEGAFAQVYEATQ---GDLNDAKNKQKFVLKVQKPANPWEFYIG 114 Query: 60 IKILKHFKHENIITIFNIQRPDSFEN----FNEVYIIQELMQT-DLHRVISTQMLSDDHI 114 ++++ K F+N E+Y L+ +L++ +++ + Sbjct: 115 TQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLV 174 Query: 115 QYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSN 148 F + L ++ +H +IH D+KP N ++ + Sbjct: 175 ISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNG 208 >5M07-A nrPDB Length = 276 Score = 32.7 bits (73), Expect = 0.28, Method: Compositional matrix adjust. Identities = 33/163 (20%), Positives = 66/163 (40%), Gaps = 23/163 (14%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLREIKILKHFKH 68 + + + +LG A G V H A+K + P F R RE ++ H Sbjct: 30 AGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFH 89 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSD--------DHIQYFIYQ 120 +I+ + D E +++I + + + +TQ ++D + + Sbjct: 90 PHILEVH-----DRGEFDGQLWIAMDYVDG----IDATQHMADRFPAVLPVGEVLAIVTA 140 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCD----LKVCDFGLA 159 A+ H ++HRD+ P+N+++ S + + DFG+A Sbjct: 141 VAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIA 183 >2CHL-A nrPDB Length = 351 Score = 32.0 bits (71), Expect = 0.40, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 26/46 (56%), Gaps = 5/46 (10%) Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCD-----LKVCDFGLAR 160 Q + ++ +H N+I+RD+KP N LI + + + DF LA+ Sbjct: 134 QLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAK 179 >4F0G-A nrPDB Length = 287 Score = 32.0 bits (71), Expect = 0.44, Method: Compositional matrix adjust. Identities = 49/232 (21%), Positives = 93/232 (40%), Gaps = 61/232 (26%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKK------------IEPFDKPLFALRTLR 58 ++ + + +G+G +G+V +VAIK IE F + R Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQE------FQR 72 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQMLSDDH-IQY 116 E+ I+ + H NI+ ++ + N ++ E + DL+ ++L H I++ Sbjct: 73 EVFIMSNLNHPNIVKLYGLMH-------NPPRMVMEFVPCGDLYH----RLLDKAHPIKW 121 Query: 117 FIYQTLR-----AVKVLHGSN--VIHRDLKPSNLLI-----NSNCDLKVCDFGLARIIDE 164 + L ++ + N ++HRDL+ N+ + N+ KV DFGL+ Sbjct: 122 SVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLS----- 176 Query: 165 SAADNSEPTGQQS--GMTEYVATRWYRAPEVMLTSAK-YSRAMDVWSCGCIL 213 QQS ++ + + APE + + Y+ D +S IL Sbjct: 177 ----------QQSVHSVSGLLGNFQWMAPETIGAEEESYTEKADTYSFAMIL 218 >5VDK-A nrPDB Length = 297 Score = 31.6 bits (70), Expect = 0.50, Method: Compositional matrix adjust. Identities = 33/138 (23%), Positives = 59/138 (42%), Gaps = 19/138 (13%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKK-IEPFDKPLFALRTLREI---KILKHFKHENIITI 74 +G G +G V + G + AIK+ ++ F + L E+ +L H H +++ Sbjct: 23 IGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH--HPHVVRY 80 Query: 75 FNIQRPDSFENFNEVYIIQE--LMQTDLHRVISTQMLSDDH-----IQYFIYQTLRAVKV 127 ++ D IIQ L IS S +H ++ + Q + Sbjct: 81 YSSWAEDDH------MIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNY 134 Query: 128 LHGSNVIHRDLKPSNLLI 145 +H S+++H D+KPSN+ I Sbjct: 135 IHNSSMVHLDIKPSNIFI 152 >5M3O-A nrPDB Length = 334 Score = 31.2 bits (69), Expect = 0.62, Method: Compositional matrix adjust. Identities = 20/51 (39%), Positives = 27/51 (52%), Gaps = 2/51 (3%) Query: 199 KYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLR 249 +Y M + ILAEL LR P FP D +H +L+ I+G+P LR Sbjct: 228 RYIGVMMLTLSPSILAELQLREPSFP--DVQHGVLIHKVILGSPAHRAGLR 276 >4CI6-B nrPDB Length = 643 Score = 30.8 bits (68), Expect = 0.82, Method: Compositional matrix adjust. Identities = 23/95 (24%), Positives = 44/95 (46%), Gaps = 16/95 (16%) Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNSEP 172 I++ ++ L L + ++H D+KP N++ + ++ + V D GL +S Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGL----------HSRS 207 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVW 207 Q G TE ++APE+ + + S DV+ Sbjct: 208 GEQPKGFTES-----FKAPELGVGNLGASEKSDVF 237 >2C47-A nrPDB Length = 313 Score = 30.8 bits (68), Expect = 0.85, Method: Compositional matrix adjust. Identities = 14/46 (30%), Positives = 26/46 (56%), Gaps = 5/46 (10%) Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLIN-----SNCDLKVCDFGLAR 160 Q + ++ +H ++I+RD+KP N L+ + + DFGLA+ Sbjct: 108 QLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAK 153 >5OAT-A nrPDB Length = 411 Score = 30.8 bits (68), Expect = 0.87, Method: Compositional matrix adjust. Identities = 28/95 (29%), Positives = 44/95 (46%), Gaps = 9/95 (9%) Query: 129 HGSNVIHRDLKPSNLLINSNCD----LKVCDFG--LARIIDESAADNSEPTGQQSGMTEY 182 HG + HRDLK NLL++++ L + DFG LA + + + + G T Sbjct: 172 HG--IAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTAL 229 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 +A + YS+A D+W+ G I E+F Sbjct: 230 MAPEIICQKPGTFSVLNYSKA-DLWAVGAIAYEIF 263 >4AZW-A nrPDB Length = 471 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 33/138 (23%), Positives = 59/138 (42%), Gaps = 20/138 (14%) Query: 47 FDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSF---------ENFNEVYIIQELMQ 97 +D P + T E + KH H I F Q P F EN +++ E + Sbjct: 269 YDMP-HGILTAEESQRNKHELHNEIK--FLTQPPAGFDAPAVLAHGENAQSGWLVMEKLP 325 Query: 98 TDLHRVISTQMLSDDHI--QYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCD 155 R++S + + + I + + LR++ L H D++P N+++++ ++ D Sbjct: 326 G---RLLSDMLAAGEEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLID 382 Query: 156 FGLARIIDESAADNSEPT 173 FG I + D S PT Sbjct: 383 FG---SIVTTPQDCSWPT 397 >6EQI-C nrPDB Length = 433 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 49/105 (46%), Gaps = 16/105 (15%) Query: 124 AVKVLHGSNVIHRDLKPSNLLIN-SNCD----LKVCDFGLARIIDESA------ADNSEP 172 AV ++ N+ HRDLK N+L++ S D + + DFG ++ +++ + Sbjct: 179 AVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDK 238 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 G ++ M +A A + Y ++ D+W+ G I E+F Sbjct: 239 GGNRALMAPEIAN----AKPGTFSWLNYKKS-DLWAVGAIAYEIF 278 >2RSV-A nrPDB Length = 403 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 20/74 (27%), Positives = 39/74 (52%), Gaps = 4/74 (5%) Query: 90 YIIQELMQTDLHRV--ISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN- 146 ++I + +DL ++ + + S + + L ++ +H +H D+K SNLL+N Sbjct: 135 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 194 Query: 147 SNCD-LKVCDFGLA 159 N D + + D+GLA Sbjct: 195 KNPDQVYLVDYGLA 208 >2LAV-A nrPDB Length = 361 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 20/74 (27%), Positives = 39/74 (52%), Gaps = 4/74 (5%) Query: 90 YIIQELMQTDLHRV--ISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN- 146 ++I + +DL ++ + + S + + L ++ +H +H D+K SNLL+N Sbjct: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 Query: 147 SNCD-LKVCDFGLA 159 N D + + D+GLA Sbjct: 188 KNPDQVYLVDYGLA 201 >4AZV-A nrPDB Length = 569 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 16/76 (21%), Positives = 38/76 (50%), Gaps = 5/76 (6%) Query: 84 ENFNEVYIIQELMQTDLHRVISTQMLSDDHI--QYFIYQTLRAVKVLHGSNVIHRDLKPS 141 EN +++ E + R++S + + + I + + LR++ L H D++P Sbjct: 312 ENAQSGWLVMEKLPG---RLLSDMLAAGEEIDREKILGSLLRSLAALEKQGFWHDDVRPW 368 Query: 142 NLLINSNCDLKVCDFG 157 N+++++ ++ DFG Sbjct: 369 NVMVDARQHARLIDFG 384 >4EV1-A nrPDB Length = 252 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 19/53 (35%), Positives = 28/53 (52%), Gaps = 7/53 (13%) Query: 220 RPIFPGRDYRHQLLLIFGIIGTPHSDND-----LRCIESPRAREYIKSLPMYP 267 +P P D Q+L I G++ T ND + + SP +REYI++LP P Sbjct: 176 KPKHPKADI--QVLDIDGVLQTLQDKNDTWLNQVVLVPSPESREYIRTLPKPP 226 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2F9G-A nrPDB 504 e-143 4QTB-A nrPDB 378 e-105 5NGU-A nrPDB 376 e-104 4EWQ-A nrPDB 370 e-103 3OHT-A nrPDB 369 e-103 4IC8-A nrPDB 366 e-102 3GC9-A nrPDB 362 e-100 4ZSG-A nrPDB 361 e-100 5Z33-A nrPDB 359 e-100 6DTL-A nrPDB 357 4e-99 1CM8-A nrPDB 355 2e-98 4MYG-A nrPDB 348 3e-96 1JNK-A nrPDB 337 4e-93 3OZ6-A nrPDB 335 2e-92 2XS0-A nrPDB 335 3e-92 3E7O-A nrPDB 333 6e-92 4QNY-A nrPDB 329 8e-91 5AWM-A nrPDB 329 9e-91 2BPM-A nrPDB 319 1e-87 3FI2-A nrPDB 313 5e-86 4O2Z-A nrPDB 308 4e-84 3RP9-A nrPDB 307 5e-84 3NIZ-A nrPDB 306 6e-84 6GU6-A nrPDB 305 2e-83 4KRC-A nrPDB 301 4e-82 1G3N-A nrPDB 297 6e-81 3N9X-A nrPDB 296 1e-80 4AU8-A nrPDB 296 1e-80 1V0B-A nrPDB 296 1e-80 3PG1-A nrPDB 293 1e-79 3NIE-A nrPDB 289 2e-78 5EFQ-A nrPDB 288 4e-78 1UA2-A nrPDB 287 7e-78 5JN2-A nrPDB 284 3e-77 4NST-A nrPDB 284 4e-77 3NCG-A nrPDB 284 5e-77 2I6L-A nrPDB 284 5e-77 4AGU-A nrPDB 282 1e-76 3DFA-A nrPDB 279 2e-75 4MVF-A nrPDB 279 2e-75 4BGQ-A nrPDB 278 2e-75 2W96-B nrPDB 278 3e-75 3MIA-A nrPDB 277 4e-75 3MA6-A nrPDB 277 4e-75 4BBM-A nrPDB 276 1e-74 5G6V-A nrPDB 276 1e-74 3LIJ-A nrPDB 271 2e-73 3HZT-A nrPDB 270 6e-73 2VN9-A nrPDB 270 8e-73 3DXN-A nrPDB 268 3e-72 2BDW-A nrPDB 267 5e-72 5FG8-A nrPDB 266 8e-72 4E7W-A nrPDB 266 1e-71 5AIR-A nrPDB 265 2e-71 2JC6-A nrPDB 264 5e-71 2V7O-A nrPDB 264 5e-71 3KK8-A nrPDB 263 8e-71 4FG9-A nrPDB 262 1e-70 5U6Y-A nrPDB 262 2e-70 3GC0-A nrPDB 261 3e-70 3BHH-A nrPDB 261 3e-70 2VZ6-A nrPDB 261 5e-70 5ES1-A nrPDB 261 5e-70 4YZB-A nrPDB 259 1e-69 5KZ7-A nrPDB 259 1e-69 3ZDU-A nrPDB 259 2e-69 4RGJ-A nrPDB 258 2e-69 2QNJ-A nrPDB 258 2e-69 3MN3-A nrPDB 256 8e-69 3SOA-A nrPDB 256 1e-68 5IG1-A nrPDB 255 2e-68 3Q5I-A nrPDB 253 9e-68 4CZT-A nrPDB 253 1e-67 3E3P-A nrPDB 252 1e-67 3H4J-B nrPDB 252 2e-67 2YCR-A nrPDB 251 4e-67 2JAM-A nrPDB 251 5e-67 4REW-A nrPDB 251 5e-67 5Y86-A nrPDB 250 5e-67 5XZW-A nrPDB 250 5e-67 5WAX-A nrPDB 250 6e-67 6C9D-A nrPDB 249 2e-66 5YKS-A nrPDB 248 3e-66 2HAK-A nrPDB 247 4e-66 3I6U-A nrPDB 247 5e-66 6FD3-A nrPDB 247 6e-66 4CQG-A nrPDB 246 1e-65 4CFF-A nrPDB 246 1e-65 3DAK-A nrPDB 246 1e-65 3COM-A nrPDB 246 2e-65 4NIF-A nrPDB 245 2e-65 4D2V-A nrPDB 245 2e-65 4CFH-A nrPDB 245 2e-65 5EZV-A nrPDB 245 2e-65 4D28-A nrPDB 245 2e-65 4RED-A nrPDB 244 3e-65 5JZN-A nrPDB 244 4e-65 3F3Z-A nrPDB 244 5e-65 3TAC-A nrPDB 244 6e-65 2HW6-A nrPDB 243 8e-65 2W4O-A nrPDB 243 8e-65 4PDS-A nrPDB 243 8e-65 5ZTN-A nrPDB 242 2e-64 3D2K-A nrPDB 242 2e-64 6O6Q-A nrPDB 242 2e-64 3ZUT-A nrPDB 241 3e-64 2YAB-A nrPDB 241 3e-64 4UZD-A nrPDB 241 5e-64 4FIE-A nrPDB 241 5e-64 4JG6-A nrPDB 240 6e-64 3EB0-A nrPDB 240 6e-64 2J90-A nrPDB 240 7e-64 3UC3-A nrPDB 240 8e-64 5DBX-A nrPDB 240 8e-64 3IS5-A nrPDB 240 8e-64 5X8I-B nrPDB 239 1e-63 4JDH-A nrPDB 239 2e-63 2YZA-A nrPDB 238 2e-63 4XBR-A nrPDB 238 2e-63 2Q0N-A nrPDB 238 2e-63 1PHK-A nrPDB 238 2e-63 2F57-A nrPDB 238 3e-63 4B6L-A nrPDB 237 4e-63 4LG4-A nrPDB 237 4e-63 3GUB-A nrPDB 237 7e-63 3DB8-A nrPDB 237 7e-63 3UDB-A nrPDB 237 7e-63 3Q53-A nrPDB 236 9e-63 6CKI-A nrPDB 236 9e-63 2Y7J-A nrPDB 236 1e-62 6AO5-A nrPDB 235 2e-62 3MV5-A nrPDB 235 2e-62 4JXF-A nrPDB 235 2e-62 3RAW-A nrPDB 235 3e-62 6FYV-A nrPDB 235 3e-62 5KCV-A nrPDB 234 4e-62 4L42-A nrPDB 234 4e-62 2OU7-A nrPDB 234 4e-62 4KS7-A nrPDB 234 5e-62 5D9K-A nrPDB 234 6e-62 2JDO-A nrPDB 233 7e-62 2A27-A nrPDB 232 1e-61 4J52-A nrPDB 232 1e-61 4QMW-A nrPDB 232 2e-61 4RLP-A nrPDB 231 3e-61 2XIK-A nrPDB 231 3e-61 6FDY-U nrPDB 231 3e-61 5D7A-A nrPDB 231 3e-61 6CMJ-A nrPDB 230 5e-61 4FZF-B nrPDB 230 7e-61 4C0T-A nrPDB 229 1e-60 1ZWS-A nrPDB 229 2e-60 2Z7Q-A nrPDB 228 2e-60 3KN6-A nrPDB 228 2e-60 3UTO-A nrPDB 228 3e-60 2UV2-A nrPDB 228 3e-60 4YNZ-A nrPDB 227 5e-60 3HKO-A nrPDB 227 5e-60 1VZO-A nrPDB 227 6e-60 5F9E-A nrPDB 226 9e-60 3HDN-A nrPDB 226 9e-60 5J5T-A nrPDB 226 1e-59 1KOA-A nrPDB 225 1e-59 5YV8-A nrPDB 225 2e-59 5UNP-A nrPDB 225 2e-59 4I6B-A nrPDB 225 2e-59 2WTK-C nrPDB 224 5e-59 4MD7-E nrPDB 223 9e-59 1FOT-A nrPDB 223 1e-58 4CRL-A nrPDB 222 2e-58 6E9W-A nrPDB 222 2e-58 2PVN-A nrPDB 221 3e-58 6ED6-A nrPDB 221 3e-58 2X4F-A nrPDB 221 4e-58 6HXF-B nrPDB 221 4e-58 2WO6-A nrPDB 221 4e-58 5XVU-A nrPDB 220 5e-58 5KKR-C nrPDB 220 8e-58 6HMD-A nrPDB 220 9e-58 2BRG-A nrPDB 219 1e-57 3TXO-A nrPDB 219 1e-57 1KOB-A nrPDB 219 2e-57 3ORZ-A nrPDB 219 2e-57 3EQC-A nrPDB 218 2e-57 4U41-A nrPDB 218 3e-57 6EII-A nrPDB 217 5e-57 1U5R-A nrPDB 217 5e-57 3LM0-A nrPDB 217 5e-57 3FXW-A nrPDB 216 9e-57 4B8L-A nrPDB 216 1e-56 4CSV-A nrPDB 216 1e-56 2GCD-A nrPDB 215 1e-56 5X3F-B nrPDB 215 2e-56 5LOH-A nrPDB 215 2e-56 4RA4-A nrPDB 215 3e-56 4WNO-A nrPDB 214 5e-56 4WB7-A nrPDB 213 9e-56 6CQF-A nrPDB 213 1e-55 6QAU-A nrPDB 212 1e-55 5DYK-A nrPDB 212 1e-55 5N23-A nrPDB 212 2e-55 3ALO-A nrPDB 212 2e-55 4AN9-A nrPDB 211 4e-55 3NYO-A nrPDB 211 5e-55 5FET-A nrPDB 210 6e-55 5MJB-A nrPDB 210 8e-55 5L6P-A nrPDB 210 1e-54 4LQP-A nrPDB 209 1e-54 3VN9-A nrPDB 209 1e-54 1S9I-A nrPDB 209 2e-54 2WQN-A nrPDB 209 2e-54 6BDL-A nrPDB 209 2e-54 3TKU-A nrPDB 209 2e-54 4AF3-A nrPDB 208 3e-54 4APC-A nrPDB 208 3e-54 2J0K-A nrPDB 208 3e-54 1NY3-A nrPDB 208 3e-54 3KA0-A nrPDB 207 4e-54 4AW2-A nrPDB 207 5e-54 2VWV-A nrPDB 207 6e-54 3A8W-A nrPDB 207 6e-54 1ZXE-A nrPDB 207 7e-54 1JPA-A nrPDB 207 7e-54 2OZA-A nrPDB 207 7e-54 2X7G-A nrPDB 206 1e-53 4EBW-A nrPDB 206 1e-53 3FME-A nrPDB 206 1e-53 6CCF-A nrPDB 206 1e-53 3PFQ-A nrPDB 205 2e-53 6E2O-A nrPDB 205 2e-53 4OLI-A nrPDB 205 3e-53 6DBN-A nrPDB 204 5e-53 4GS6-A nrPDB 204 7e-53 2H8H-A nrPDB 203 8e-53 2I0E-A nrPDB 203 1e-52 6F3F-A nrPDB 203 1e-52 3DKO-A nrPDB 202 2e-52 6DBM-A nrPDB 202 2e-52 4TNB-A nrPDB 202 2e-52 2Y6O-A nrPDB 201 3e-52 4OTD-A nrPDB 201 3e-52 6BXI-A nrPDB 201 4e-52 4P5Q-A nrPDB 201 4e-52 2R2P-A nrPDB 200 6e-52 2FO0-A nrPDB 200 6e-52 4XEY-B nrPDB 200 8e-52 4E20-A nrPDB 200 8e-52 6GQK-A nrPDB 200 1e-51 4FR4-A nrPDB 200 1e-51 4WUA-A nrPDB 200 1e-51 4E93-A nrPDB 200 1e-51 4M7I-A nrPDB 199 1e-51 3PPZ-A nrPDB 199 2e-51 5SYS-A nrPDB 199 2e-51 2XNP-A nrPDB 198 3e-51 3QA8-A nrPDB 198 3e-51 3C51-A nrPDB 198 4e-51 3OMV-A nrPDB 197 4e-51 6NPU-A nrPDB 197 4e-51 2VD5-A nrPDB 197 5e-51 2DQ7-X nrPDB 197 6e-51 3ORP-A nrPDB 197 7e-51 4KIK-B nrPDB 196 1e-50 6GVJ-A nrPDB 196 1e-50 4LFI-A nrPDB 195 2e-50 4CRS-A nrPDB 195 3e-50 4UY9-A nrPDB 195 3e-50 4PDO-A nrPDB 195 3e-50 2XYN-A nrPDB 195 3e-50 5TQX-A nrPDB 194 5e-50 3BBT-B nrPDB 194 5e-50 2OGV-A nrPDB 194 6e-50 4UYA-A nrPDB 194 6e-50 5H2U-A nrPDB 194 6e-50 5UUU-A nrPDB 194 7e-50 4XCU-A nrPDB 194 7e-50 5TUR-A nrPDB 194 7e-50 3DTC-A nrPDB 194 8e-50 6FEX-A nrPDB 193 8e-50 3KUL-B nrPDB 193 8e-50 3BEA-A nrPDB 193 1e-49 3TT0-A nrPDB 193 1e-49 3PVW-A nrPDB 193 1e-49 5HIE-A nrPDB 193 1e-49 5HI2-A nrPDB 192 1e-49 3BGP-A nrPDB 192 1e-49 1TKI-A nrPDB 192 2e-49 4EQM-A nrPDB 192 2e-49 5HVK-A nrPDB 192 2e-49 6BSD-A nrPDB 192 2e-49 3PP0-A nrPDB 192 2e-49 3KRL-A nrPDB 192 2e-49 5A46-A nrPDB 192 3e-49 3HMP-A nrPDB 191 3e-49 3LLT-A nrPDB 191 4e-49 4R7H-A nrPDB 190 6e-49 3GQL-A nrPDB 190 6e-49 4RC3-A nrPDB 190 8e-49 6B2Q-A nrPDB 190 8e-49 4X3F-A nrPDB 190 8e-49 4OW8-A nrPDB 190 8e-49 5AP3-A nrPDB 189 2e-48 2ZMD-A nrPDB 189 2e-48 3V5Q-A nrPDB 189 2e-48 3CJF-A nrPDB 189 2e-48 2WTK-B nrPDB 189 2e-48 3A4O-X nrPDB 189 2e-48 5B2L-A nrPDB 188 3e-48 4IAN-A nrPDB 188 3e-48 5X5O-A nrPDB 188 3e-48 1K9A-A nrPDB 188 3e-48 5O0Y-A nrPDB 188 4e-48 4C59-A nrPDB 188 4e-48 4YHJ-A nrPDB 187 5e-48 5KMM-A nrPDB 187 7e-48 4AT3-A nrPDB 187 8e-48 2PSQ-A nrPDB 186 1e-47 4K33-A nrPDB 186 1e-47 1FVR-A nrPDB 185 2e-47 4H1J-A nrPDB 185 2e-47 4XLV-A nrPDB 185 2e-47 2W1I-A nrPDB 185 2e-47 5AMN-A nrPDB 185 3e-47 5GNK-A nrPDB 185 3e-47 3IO7-A nrPDB 185 3e-47 3LZB-A nrPDB 184 4e-47 5VO2-A nrPDB 184 4e-47 4XUF-A nrPDB 184 4e-47 1BYG-A nrPDB 184 4e-47 4X7Q-B nrPDB 184 6e-47 5X02-A nrPDB 184 7e-47 3G0E-A nrPDB 184 8e-47 5U6B-A nrPDB 184 8e-47 4HVI-A nrPDB 183 8e-47 5O2B-A nrPDB 183 9e-47 4TPT-A nrPDB 183 1e-46 3QGY-A nrPDB 183 1e-46 5EG3-A nrPDB 182 2e-46 5O2C-A nrPDB 182 2e-46 2HK5-A nrPDB 182 2e-46 6FER-A nrPDB 182 2e-46 4PWN-A nrPDB 182 2e-46 4NEU-A nrPDB 182 2e-46 4PL5-B nrPDB 182 3e-46 2PL0-A nrPDB 182 3e-46 3Q4U-A nrPDB 181 3e-46 2JD5-A nrPDB 181 4e-46 6CTH-A nrPDB 181 4e-46 3M42-A nrPDB 181 5e-46 5UIU-A nrPDB 180 5e-46 5GRN-A nrPDB 180 6e-46 6HV0-A nrPDB 180 6e-46 4LRM-A nrPDB 180 6e-46 5FM2-A nrPDB 180 8e-46 3DLS-A nrPDB 180 8e-46 3PLS-A nrPDB 180 9e-46 1U59-A nrPDB 180 9e-46 1LUF-A nrPDB 179 2e-45 3QD2-B nrPDB 179 2e-45 2OZO-A nrPDB 178 2e-45 3C1X-A nrPDB 178 3e-45 5HLW-A nrPDB 178 4e-45 4YFF-A nrPDB 178 4e-45 2RIO-A nrPDB 177 4e-45 3QUP-A nrPDB 177 5e-45 4Y93-A nrPDB 177 6e-45 3ZBF-A nrPDB 177 6e-45 3MDY-A nrPDB 177 8e-45 4XI2-A nrPDB 177 8e-45 5TOS-A nrPDB 177 1e-44 1AD5-A nrPDB 176 1e-44 6E4F-A nrPDB 176 1e-44 5VD3-A nrPDB 176 1e-44 4Y83-A nrPDB 176 1e-44 2A1A-B nrPDB 175 3e-44 3I81-A nrPDB 175 3e-44 3SXS-A nrPDB 174 6e-44 3G2F-A nrPDB 174 6e-44 5WNL-A nrPDB 173 7e-44 4HZS-A nrPDB 173 9e-44 5U6C-A nrPDB 173 9e-44 5XD6-A nrPDB 172 2e-43 1U54-B nrPDB 172 3e-43 6J5U-C nrPDB 172 3e-43 3MY0-A nrPDB 171 3e-43 3UIU-A nrPDB 170 6e-43 3AOX-A nrPDB 170 6e-43 1PY5-A nrPDB 170 8e-43 4IDT-A nrPDB 169 2e-42 4F9B-A nrPDB 169 2e-42 3SOC-A nrPDB 168 3e-42 5LPZ-A nrPDB 168 3e-42 5LPV-A nrPDB 167 5e-42 2BUJ-A nrPDB 167 7e-42 3UIM-A nrPDB 165 3e-41 5IKW-A nrPDB 164 5e-41 2PMN-X nrPDB 163 7e-41 4G3E-A nrPDB 163 1e-40 4JLC-A nrPDB 162 1e-40 5WNO-A nrPDB 162 2e-40 4FL3-A nrPDB 162 2e-40 4EUU-A nrPDB 162 2e-40 5TE0-A nrPDB 161 4e-40 4EUT-A nrPDB 160 6e-40 5CEK-A nrPDB 160 1e-39 6DC0-A nrPDB 160 1e-39 3ZZW-A nrPDB 159 2e-39 6O8B-A nrPDB 159 2e-39 5C26-A nrPDB 158 3e-39 6NT9-A nrPDB 158 4e-39 5E8V-A nrPDB 157 5e-39 4M66-A nrPDB 156 1e-38 2QKW-B nrPDB 156 1e-38 2H34-A nrPDB 156 1e-38 6BFN-A nrPDB 154 6e-38 5AR8-A nrPDB 152 2e-37 2QLU-A nrPDB 152 2e-37 3LMG-A nrPDB 151 5e-37 2Y4I-B nrPDB 147 9e-36 4BTK-A nrPDB 146 2e-35 4NFN-A nrPDB 145 4e-35 3SV0-A nrPDB 143 1e-34 4TN6-A nrPDB 137 5e-33 5J0A-A nrPDB 137 6e-33 5FQD-C nrPDB 137 7e-33 5L2Q-C nrPDB 135 2e-32 4M69-B nrPDB 133 1e-31 4BTF-A nrPDB 133 1e-31 2PZI-A nrPDB 133 1e-31 4Y12-A nrPDB 133 2e-31 3VHK-A nrPDB 130 8e-31 4JRN-A nrPDB 130 8e-31 3HNG-A nrPDB 127 9e-30 5X1R-A nrPDB 125 4e-29 4RT7-A nrPDB 122 3e-28 5X18-A nrPDB 118 4e-27 4L68-A nrPDB 107 7e-24 5CLR-A nrPDB 82 5e-16 Sequences not found previously or not previously below threshold: 4F0G-A nrPDB 157 9e-39 5VC6-A nrPDB 130 1e-30 5VDK-A nrPDB 127 9e-30 4MWI-A nrPDB 126 2e-29 2CHL-A nrPDB 122 3e-28 4NT4-A nrPDB 121 4e-28 2CMW-A nrPDB 119 2e-27 2C47-A nrPDB 118 5e-27 4XHH-A nrPDB 118 5e-27 4XHL-A nrPDB 115 3e-26 1CSN-A nrPDB 111 6e-25 5M07-A nrPDB 108 4e-24 5OAT-A nrPDB 105 3e-23 4L00-A nrPDB 105 3e-23 5USZ-A nrPDB 105 4e-23 5UV4-A nrPDB 99 2e-21 6EQI-C nrPDB 98 4e-21 3REP-A nrPDB 93 2e-19 5C01-A nrPDB 89 3e-18 4WOV-A nrPDB 88 4e-18 6J6I-B nrPDB 87 2e-17 4I94-A nrPDB 85 3e-17 5UU1-A nrPDB 83 2e-16 2RSV-A nrPDB 78 6e-15 4IX6-A nrPDB 77 8e-15 2LAV-A nrPDB 77 1e-14 4CI6-B nrPDB 72 4e-13 4O1O-A nrPDB 71 9e-13 6G4J-A nrPDB 71 1e-12 4OAU-C nrPDB 67 2e-11 5DMZ-A nrPDB 66 3e-11 5GZA-A nrPDB 63 2e-10 6BHC-A nrPDB 62 5e-10 2JII-A nrPDB 61 7e-10 6EAS-A nrPDB 57 1e-08 4CYJ-A nrPDB 57 1e-08 6M7Z-A nrPDB 57 1e-08 5GZ9-A nrPDB 56 3e-08 6EWX-A nrPDB 55 3e-08 3ENH-A nrPDB 53 2e-07 4AZV-A nrPDB 51 7e-07 4AZW-A nrPDB 51 7e-07 5VE6-A nrPDB 51 1e-06 4BWP-A nrPDB 48 7e-06 6R5K-O nrPDB 48 8e-06 6G38-A nrPDB 47 1e-05 4XR7-L nrPDB 46 3e-05 4CZY-B nrPDB 43 2e-04 4WWA-A nrPDB 43 2e-04 3DZO-A nrPDB 41 6e-04 3BYV-A nrPDB 41 7e-04 1TQM-A nrPDB 41 0.001 3Q60-A nrPDB 40 0.002 6FAI-l nrPDB 39 0.003 2W1Z-A nrPDB 37 0.011 5YK0-A nrPDB 36 0.020 4BVU-A nrPDB 36 0.033 4ZO4-A nrPDB 35 0.039 6G18-v nrPDB 33 0.18 6FDN-A nrPDB 32 0.38 6EF6-A nrPDB 30 1.5 6GML-W nrPDB 30 1.6 >2F9G-A nrPDB Length = 353 Score = 504 bits (1299), Expect = e-143, Method: Composition-based stats. Identities = 353/353 (100%), Positives = 353/353 (100%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI Sbjct: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ Sbjct: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT Sbjct: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG Sbjct: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA Sbjct: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 Query: 301 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS Sbjct: 301 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 >4QTB-A nrPDB Length = 380 Score = 378 bits (970), Expect = e-105, Method: Composition-based stats. Identities = 175/350 (50%), Positives = 232/350 (66%), Gaps = 12/350 (3%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 M K +++ + +GEGAYG+V SA VAIKKI PF+ + RTLREI Sbjct: 31 MVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREI 90 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 +IL F+HEN+I I +I R + E +VYI+Q+LM+TDL++++ +Q LS+DHI YF+YQ Sbjct: 91 QILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQ 150 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 LR +K +H +NV+HRDLKPSNLLIN+ CDLK+CDFGLARI D +T Sbjct: 151 ILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH-------DHTGFLT 203 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 EYVATRWYRAPE+ML S Y++++D+WS GCILAE+ RPIFPG+ Y QL I GI+G Sbjct: 204 EYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILG 263 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 +P S DL CI + +AR Y++SLP K+FP+ + K +DLL RML F+P KRIT Sbjct: 264 SP-SQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITV 322 Query: 301 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNE 350 +EAL HPYL+ Y+DP DEP E F F + L + LK+LI+ E Sbjct: 323 EEALAHPYLEQYYDPTDEPVAEE----PFTFAMELDDLPKERLKELIFQE 368 >5NGU-A nrPDB Length = 381 Score = 376 bits (965), Expect = e-104, Method: Composition-based stats. Identities = 176/350 (50%), Positives = 237/350 (67%), Gaps = 12/350 (3%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 M + V+++ + S +GEGAYG+VCSA VAIKKI PF+ + RTLREI Sbjct: 32 MVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREI 91 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 KIL F+HENII I +I R + E +VYI+Q+LM+TDL++++ TQ LS+DHI YF+YQ Sbjct: 92 KILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQ 151 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 LR +K +H +NV+HRDLKPSNLL+N+ CDLK+CDFGLAR+ D +T Sbjct: 152 ILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDH-------DHTGFLT 204 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 EYVATRWYRAPE+ML S Y++++D+WS GCILAE+ RPIFPG+ Y QL I GI+G Sbjct: 205 EYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILG 264 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 +P S DL CI + +AR Y+ SLP P ++FP + K +DLL +ML F+P KRI Sbjct: 265 SP-SQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEV 323 Query: 301 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNE 350 ++AL HPYL+ Y+DP+DEP E + F+FD + L + LK+LI+ E Sbjct: 324 EQALAHPYLEQYYDPSDEPIAE----APFKFDMELDDLPKEKLKELIFEE 369 >4EWQ-A nrPDB Length = 383 Score = 370 bits (949), Expect = e-103, Method: Composition-based stats. Identities = 158/353 (44%), Positives = 219/353 (62%), Gaps = 21/353 (5%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIK 61 + ++ + +Q S +G GAYG VC+A TG VA+KK+ PF + A RT RE++ Sbjct: 37 NKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELR 96 Query: 62 ILKHFKHENIITIFNIQRP-DSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 +LKH KHEN+I + ++ P S E FN+VY++ LM DL+ ++ Q L+DDH+Q+ IYQ Sbjct: 97 LLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQ 156 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 LR +K +H +++IHRDLKPSNL +N +C+LK+ DFGLAR D+ MT Sbjct: 157 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------------MT 203 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 YVATRWYRAPE+ML Y++ +D+WS GCI+AEL R +FPG D+ QL LI ++G Sbjct: 204 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 263 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 TP ++ L+ I S AR YI+SL P +F NP +DLL++MLV D KRITA Sbjct: 264 TPGAEL-LKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITA 322 Query: 301 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 +AL H Y YHDP+DEP +P SF D L + K L ++E+ S Sbjct: 323 AQALAHAYFAQYHDPDDEPVADPYDQSFESRD-----LLIDEWKSLTYDEVIS 370 >3OHT-A nrPDB Length = 389 Score = 369 bits (948), Expect = e-103, Method: Composition-based stats. Identities = 158/353 (44%), Positives = 216/353 (61%), Gaps = 21/353 (5%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIK 61 + ++ + +Q S +G GAYG VCS+ +G +A+KK+ PF + A RT RE++ Sbjct: 43 NKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELR 102 Query: 62 ILKHFKHENIITIFNIQRP-DSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 +LKH KHEN+I + ++ P S E FN+VY++ LM DL+ ++ Q L+DDH+Q+ IYQ Sbjct: 103 LLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQ 162 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 LR +K +H +++IHRDLKPSNL +N +C+LK+ DFGLAR D+ MT Sbjct: 163 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------------MT 209 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 YVATRWYRAPE+ML Y+ +D+WS GCI+AEL R +FPG D+ +QL I + G Sbjct: 210 GYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 269 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 TP + R S AR YI SLP P +F NP +DLL++MLV D KRITA Sbjct: 270 TPPASVISRM-PSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITA 328 Query: 301 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 EAL HPY YHDP+DEPE EP SF L ++ K+L + E+ S Sbjct: 329 SEALAHPYFSQYHDPDDEPESEPYDQSF-----ESRQLEIEEWKRLTYEEVCS 376 >4IC8-A nrPDB Length = 442 Score = 366 bits (940), Expect = e-102, Method: Composition-based stats. Identities = 168/351 (47%), Positives = 239/351 (68%), Gaps = 14/351 (3%) Query: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKI 62 + +++ ++++ +G GAYGVV SA + TG+ VAIKKI FD A RTLRE+KI Sbjct: 48 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 107 Query: 63 LKHFKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQ 120 LKHFKH+NII I +I RP + F VY++ +LM++DLH++I S+Q L+ +H++YF+YQ Sbjct: 108 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 167 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 LR +K +H + VIHRDLKPSNLL+N NC+LK+ DFG+AR + + P Q MT Sbjct: 168 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLC------TSPAEHQYFMT 221 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 EYVATRWYRAPE+ML+ +Y++A+D+WS GCI E+ RR +FPG++Y HQL LI ++G Sbjct: 222 EYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLG 281 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 TP S ++ + + R R YI+SLP P E ++P + + + LL RML F+P+ RI+A Sbjct: 282 TP-SPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISA 340 Query: 301 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 AL HP+L YHDP+DEP+ P F+F +EALT + +K+ I EI Sbjct: 341 AAALRHPFLAKYHDPDDEPDCAP----PFDFAFDREALTRERIKEAIVAEI 387 >3GC9-A nrPDB Length = 370 Score = 362 bits (930), Expect = e-100, Method: Composition-based stats. Identities = 156/353 (44%), Positives = 214/353 (60%), Gaps = 21/353 (5%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIK 61 + V+ + Q +G GAYG VCSA + VA+KK+ PF + A RT RE++ Sbjct: 20 NKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELR 79 Query: 62 ILKHFKHENIITIFNIQRP-DSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 +LKH KHEN+I + ++ P S E+F+EVY++ LM DL+ ++ +Q LSD+H+Q+ +YQ Sbjct: 80 LLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQALSDEHVQFLVYQ 139 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 LR +K +H + +IHRDLKPSN+ +N + +L++ DFGLAR DE MT Sbjct: 140 LLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEE-------------MT 186 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 YVATRWYRAPE+ML Y++ +D+WS GCI+AEL + +FPG DY QL I ++G Sbjct: 187 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 246 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 TP S L I S AR YI+SLP P L +F NP IDLL RMLV D +R++A Sbjct: 247 TP-SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA 305 Query: 301 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 EAL H Y YHDP DEPE EP S + T ++ K+L + E+ S Sbjct: 306 AEALAHAYFSQYHDPEDEPEAEPYDESVEAKER-----TLEEWKELTYQEVLS 353 >4ZSG-A nrPDB Length = 347 Score = 361 bits (927), Expect = e-100, Method: Composition-based stats. Identities = 168/350 (48%), Positives = 239/350 (68%), Gaps = 14/350 (4%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKIL 63 + +++ ++++ +G GAYGVV SA + TG+ VAIKKI FD A RTLRE+KIL Sbjct: 1 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 60 Query: 64 KHFKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQT 121 KHFKH+NII I +I RP + F VY++ +LM++DLH++I S+Q L+ +H++YF+YQ Sbjct: 61 KHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQL 120 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 LR +K +H + VIHRDLKPSNLL+N NC+LK+ DFG+AR + + P Q MTE Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLC------TSPAEHQYFMTE 174 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 YVATRWYRAPE+ML+ +Y++A+D+WS GCI E+ RR +FPG++Y HQL LI ++GT Sbjct: 175 YVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGT 234 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 P S ++ + + R R YI+SLP P E ++P + + + LL RML F+P+ RI+A Sbjct: 235 P-SPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAA 293 Query: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 AL HP+L YHDP+DEP+ P F+F +EALT + +K+ I EI Sbjct: 294 AALRHPFLAKYHDPDDEPDCAP----PFDFAFDREALTRERIKEAIVAEI 339 >5Z33-A nrPDB Length = 425 Score = 359 bits (922), Expect = e-100, Method: Composition-based stats. Identities = 166/349 (47%), Positives = 230/349 (65%), Gaps = 16/349 (4%) Query: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKH 65 + + + + LG+GAYG+VC+A + T E VAIKK+ F K + A R LREIK+L+H Sbjct: 27 FIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQH 86 Query: 66 FK-HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST-QMLSDDHIQYFIYQTLR 123 F+ H NI ++++ P +NFNE Y+ +ELM+ DL +I + Q L+D H Q FIYQ L Sbjct: 87 FRGHRNITCLYDMDIPRP-DNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILC 145 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 +K +H +NV+HRDLKP NLL+N++C+LK+CDFGLAR P MTEYV Sbjct: 146 GLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVD------PEENAGYMTEYV 199 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 ATRWYRAPE+ML+ Y++A+DVWS GCILAEL RP F GRDY QL I I+GTP+ Sbjct: 200 ATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPN 259 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 + L I SPRA+EY+++LP P +FP NP +DLL RML FDP+ RI+ ++A Sbjct: 260 -EETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQA 318 Query: 304 LEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIF 352 LEHPYL +HD +DEP+ P+ F FD ++ +++K+I +E++ Sbjct: 319 LEHPYLHIWHDASDEPDC----PTTFNFD-FEVVEDVGEMRKMILDEVY 362 >6DTL-A nrPDB Length = 364 Score = 357 bits (916), Expect = 4e-99, Method: Composition-based stats. Identities = 172/351 (49%), Positives = 233/351 (66%), Gaps = 20/351 (5%) Query: 6 VYNISSDFQL-KSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKIL 63 ++ +++ ++ +G+GAYG+VCSA + T E VAIKKI FD + A RTLREIK+L Sbjct: 24 IFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLL 83 Query: 64 KHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST-QMLSDDHIQYFIYQTL 122 +H HENI+ I +I P FN+VYI ELM TDLH++I + Q LS++H QYF+YQ L Sbjct: 84 RHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQIL 143 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 R +K +H +NV+HRDLKPSNLL+N+NCDLK+CDFGLAR+ T + MTEY Sbjct: 144 RGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV-----------TSESDFMTEY 192 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 V TRWYRAPE++L S+ Y+ A+DVWS GCI EL R+P+FPGRD+ HQL L+ +IGTP Sbjct: 193 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 252 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 + + A+ YI+ LP YP + FP V+P IDL+++ML FDP +RIT + Sbjct: 253 --SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLD 310 Query: 303 ALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 AL HPYL + HD +DEPE F FD AL+ + +K+LI+ E + Sbjct: 311 ALAHPYLNSLHDISDEPECT----IPFNFDFENHALSEEQMKELIYREALA 357 >1CM8-A nrPDB Length = 367 Score = 355 bits (910), Expect = 2e-98, Method: Composition-based stats. Identities = 134/353 (37%), Positives = 209/353 (59%), Gaps = 21/353 (5%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIK 61 + + + + ++ +G GAYG VCSA TG VAIKK+ PF LFA R RE++ Sbjct: 17 TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76 Query: 62 ILKHFKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 +LKH +HEN+I + ++ PD + ++F + Y++ M TDL +++ + L +D IQ+ +YQ Sbjct: 77 LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQ 136 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 L+ ++ +H + +IHRDLKP NL +N +C+LK+ DFGLAR D MT Sbjct: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-------------MT 183 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 YV TRWYRAPEV+L +Y++ +D+WS GCI+AE+ + +F G D+ QL I + G Sbjct: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 TP ++ R ++S A+ Y+K LP + +P ++LL++MLV D +R+TA Sbjct: 244 TPPAEFVQR-LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA 302 Query: 301 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 EAL HPY ++ HD DEP+ + SF + D T + K++ + E+ S Sbjct: 303 GEALAHPYFESLHDTEDEPQVQKYDDSFDDVDR-----TLDEWKRVTYKEVLS 350 >4MYG-A nrPDB Length = 372 Score = 348 bits (892), Expect = 3e-96, Method: Composition-based stats. Identities = 139/353 (39%), Positives = 211/353 (59%), Gaps = 21/353 (5%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIK 61 + + + + + +G GAYG VCSA K +GE VAIKK+ PF +FA R RE+ Sbjct: 35 NKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELL 94 Query: 62 ILKHFKHENIITIFNIQRP-DSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQ 120 +LKH +HEN+I + ++ P S NF + Y++ MQTDL +++ + S++ IQY +YQ Sbjct: 95 LLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKIQYLVYQ 153 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 L+ +K +H + V+HRDLKP NL +N +C+LK+ DFGLAR D MT Sbjct: 154 MLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE-------------MT 200 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 YV TRWYRAPEV+L+ Y++ +D+WS GCI+AE+ + +F G+DY QL I + G Sbjct: 201 GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG 260 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 P ++ ++ + A+ YI+SLP P ++FPR +P+ DLL++ML D KR+TA Sbjct: 261 VPGTEF-VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTA 319 Query: 301 KEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 +AL HP+ + + DP +E E + F+ E LT + K+ I+ EI + Sbjct: 320 AQALTHPFFEPFRDPEEETEAQ----QPFDDSLEHEKLTVDEWKQHIYKEIVN 368 >1JNK-A nrPDB Length = 423 Score = 337 bits (865), Expect = 4e-93, Method: Composition-based stats. Identities = 131/362 (36%), Positives = 196/362 (54%), Gaps = 32/362 (8%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILK 64 + + +Q +G GA G+VC+A VAIKK+ PF A R RE+ ++K Sbjct: 57 TFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMK 116 Query: 65 HFKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLR 123 H+NII++ N+ P + E F +VY++ ELM +L +VI + L + + Y +YQ L Sbjct: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLC 175 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 +K LH + +IHRDLKPSN+++ S+C LK+ DFGLAR G MT YV Sbjct: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR-----------TAGTSFMMTPYV 224 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 TR+YRAPEV+L Y +D+WS GCI+ E+ + +FPGRDY Q + +GTP Sbjct: 225 VTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC 283 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRV------------NPKGIDLLQRMLV 291 + + P R Y+++ P Y K+FP + DLL +MLV Sbjct: 284 PEFMKKL--QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 Query: 292 FDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 DPAKRI+ +AL+HPY+ ++DP E E PP ++ + T ++ K+LI+ E+ Sbjct: 342 IDPAKRISVDDALQHPYINVWYDPA---EVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 Query: 352 FS 353 + Sbjct: 399 MN 400 >3OZ6-A nrPDB Length = 388 Score = 335 bits (859), Expect = 2e-92, Method: Composition-based stats. Identities = 140/377 (37%), Positives = 215/377 (57%), Gaps = 36/377 (9%) Query: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKI 62 R+ ++ ++L LG+GAYG+V + + TGE+VA+KKI + F A RT REI I Sbjct: 2 RVDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMI 61 Query: 63 LKHFK-HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQT 121 L HENI+ + N+ R D N +VY++ + M+TDLH VI +L H QY +YQ Sbjct: 62 LTELSGHENIVNLLNVLRAD---NDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQL 118 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESA-----------ADNS 170 ++ +K LH ++HRD+KPSN+L+N+ C +KV DFGL+R + Sbjct: 119 IKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTE 178 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 Q +T+YVATRWYRAPE++L S KY++ +D+WS GCIL E+ +PIFPG + Sbjct: 179 NFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMN 238 Query: 231 QLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPA----------APLEKMFPRVNP 280 QL I G+I P S+ D+ I+SP A+ I+SL + + ++NP Sbjct: 239 QLERIIGVIDFP-SNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINP 297 Query: 281 ------KGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHY 334 + +DLL ++L F+P KRI+A +AL+HP++ +H+PN+EP + I + Sbjct: 298 KADCNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIP---IND 354 Query: 335 KEALTTKDLKKLIWNEI 351 + D + L+++EI Sbjct: 355 NVKHSIDDYRNLVYSEI 371 >2XS0-A nrPDB Length = 386 Score = 335 bits (858), Expect = 3e-92, Method: Composition-based stats. Identities = 130/361 (36%), Positives = 192/361 (53%), Gaps = 32/361 (8%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILK 64 + + +Q +G GA G+VC+A VAIKK+ PF A R RE+ ++K Sbjct: 21 TFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMK 80 Query: 65 HFKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLR 123 H+NII + N+ P S E F +VYI+ ELM +L +VI + L + + Y +YQ L Sbjct: 81 CVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLC 139 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 +K LH + +IHRDLKPSN+++ S+C LK+ DFGLAR G M +V Sbjct: 140 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR-----------TAGTSFMMVPFV 188 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 TR+YRAPEV+L Y +D+WS GCI+ E+ +FPG D+ Q + +GTP Sbjct: 189 VTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPC 247 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRV------------NPKGIDLLQRMLV 291 + + P R Y+++ P Y EK+FP V + DLL +MLV Sbjct: 248 PEFMKKL--QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLV 305 Query: 292 FDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 D +KRI+ EAL+HPY+ ++DP+ E E PP + + T ++ K+LI+ E+ Sbjct: 306 IDASKRISVDEALQHPYINVWYDPS---EAEAPPPKIPDKQLDEREHTIEEWKELIYKEV 362 Query: 352 F 352 Sbjct: 363 M 363 >3E7O-A nrPDB Length = 360 Score = 333 bits (855), Expect = 6e-92, Method: Composition-based stats. Identities = 130/361 (36%), Positives = 191/361 (52%), Gaps = 32/361 (8%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILK 64 + + +Q +G GA G+VC+A G VA+KK+ PF A R RE+ +LK Sbjct: 17 TFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLK 76 Query: 65 HFKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLR 123 H+NII++ N+ P + E F +VY++ ELM +L +VI + L + + Y +YQ L Sbjct: 77 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLYQMLC 135 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 +K LH + +IHRDLKPSN+++ S+C LK+ DFGLAR MT YV Sbjct: 136 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR-----------TASTNFMMTPYV 184 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 TR+YRAPEV+L Y +D+WS GCI+ EL IF G D+ Q + +GTP Sbjct: 185 VTRYYRAPEVILGMG-YKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPS 243 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRV------------NPKGIDLLQRMLV 291 ++ P R Y+++ P YP E++FP + DLL +MLV Sbjct: 244 AE--FMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLV 301 Query: 292 FDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 DP KRI+ EAL HPY+ ++DP E E PP ++ + ++ K+LI+ E+ Sbjct: 302 IDPDKRISVDEALRHPYITVWYDPA---EAEAPPPQIYDAQLEEREHAIEEWKELIYKEV 358 Query: 352 F 352 Sbjct: 359 M 359 >4QNY-A nrPDB Length = 354 Score = 329 bits (845), Expect = 8e-91, Method: Composition-based stats. Identities = 146/349 (41%), Positives = 218/349 (62%), Gaps = 20/349 (5%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATH-KPTGEIVAIKKIEP--FDKPLFALRTLREIKI 62 V + + L+ ++G G+YGVV A K +VA+K++ F++ + A R LREIK+ Sbjct: 15 VCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKL 74 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST-QMLSDDHIQYFIYQT 121 L HF +NII + NI P+ ENF+ YI+ ++M+TDL +V+ + Q L++ HIQ+FIYQ Sbjct: 75 LAHFNDDNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQFFIYQA 134 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 LRA+ ++H + VIHRD+ P+N+L+N+NCDLK+CDFGLA+ E Q MT+ Sbjct: 135 LRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAK----------EENDQGEYMTD 184 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 YV RWYRAPE+++ YS +DVW GCIL EL RP+F G+D +QL I +IGT Sbjct: 185 YVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGT 244 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 P S+ D+ + S A++Y+K P A + +P +P+ +DLL+ MLVF+P +RIT Sbjct: 245 P-SEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVL 303 Query: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNE 350 +A+ HP+L+ HD D + + + F FD E T D+K+ I+ E Sbjct: 304 QAMRHPFLEQLHDDAD----DNLSYALFRFD-ENEQKTIVDVKRAIYEE 347 >5AWM-A nrPDB Length = 394 Score = 329 bits (845), Expect = 9e-91, Method: Composition-based stats. Identities = 128/361 (35%), Positives = 188/361 (52%), Gaps = 33/361 (9%) Query: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKH 65 + I S + +G GA G+VC+A T + VAIKK+ PF A R RE K++K Sbjct: 40 FTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 99 Query: 66 FKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRA 124 H+NII + N P + E F +VY++ ELM +L +VI L D + Y +YQ L Sbjct: 100 VNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD-LDHDRMSYLLYQMLCG 158 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 +K LH + +IHRDLKPSN+++ ++C LK+ DFGLAR G MT YV Sbjct: 159 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLAR-----------TAGTTFMMTPYVV 207 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 TR+YRAPEV+L Y+ +D+WS GCI+ E+ +FPG D+ Q I +GTP Sbjct: 208 TRYYRAPEVILGMG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSP 266 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFP-------------RVNPKGIDLLQRMLV 291 R P R Y+++ P Y +++FP R +LL +MLV Sbjct: 267 SFMQRL--QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLV 324 Query: 292 FDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 DP +RI+ EAL+H Y+ ++D E + P ++ + T + K+LI+ E+ Sbjct: 325 IDPEQRISVDEALKHEYINVWYDAE---EVDAPAPEPYDHSVDEREHTVEQWKELIYEEV 381 Query: 352 F 352 Sbjct: 382 M 382 >2BPM-A nrPDB Length = 309 Score = 319 bits (818), Expect = 1e-87, Method: Composition-based stats. Identities = 113/309 (36%), Positives = 159/309 (51%), Gaps = 22/309 (7%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP-FDKPLFALRTLREIKILKHFKHE 69 +FQ +GEG YGVV A +K TGE+VA+KKI + +REI +LK H Sbjct: 7 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 66 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLS---DDHIQYFIYQTLRAVK 126 NI+ + ++ N++Y++ E + DL + + L+ I+ +++Q L+ + Sbjct: 67 NIVKLLDVI-----HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 121 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H V+HRDLKP NLLIN+ +K+ DFGLAR T V T Sbjct: 122 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV----------RTYTHEVVTL 171 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 WYRAPE++L YS A+D+WS GCI AE+ RR +FPG QL IF +GTP Sbjct: 172 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVV 231 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 P +Y S P + K+ P ++ G LL +ML +DP KRI+AK AL H Sbjct: 232 WPGVTSMP---DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAH 288 Query: 307 PYLQTYHDP 315 P+ Q P Sbjct: 289 PFFQDVTKP 297 >3FI2-A nrPDB Length = 353 Score = 313 bits (803), Expect = 5e-86, Method: Composition-based stats. Identities = 125/362 (34%), Positives = 188/362 (51%), Gaps = 43/362 (11%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILK 64 + + +Q +G GA G+VC+A VAIKK+ PF A R RE+ ++K Sbjct: 19 TFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMK 78 Query: 65 HFKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLR 123 H+NII++ N+ P + E F +VY++ ELM +L +VI + L + + Y +YQ L Sbjct: 79 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLC 137 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 +K LH + +IHRDLKPSN+++ S+C LK+ DFGLAR G MT YV Sbjct: 138 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR-----------TAGTSFMMTPYV 186 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 TR+YRAPEV+L Y +D+WS GCI+ E+ + +FPGRDY Q + +GTP Sbjct: 187 VTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC 245 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRV------------NPKGIDLLQRMLV 291 + + P R Y+++ P Y K+FP + DLL +MLV Sbjct: 246 PEFMKKL--QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 303 Query: 292 FDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 DPAKRI+ +AL+HPY+ ++ + T ++ K+LI+ E+ Sbjct: 304 IDPAKRISVDDALQHPYINVWYX--------------XXXXXDEREHTIEEWKELIYKEV 349 Query: 352 FS 353 + Sbjct: 350 MN 351 >4O2Z-A nrPDB Length = 377 Score = 308 bits (788), Expect = 4e-84, Method: Composition-based stats. Identities = 140/353 (39%), Positives = 205/353 (58%), Gaps = 25/353 (7%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILK 64 + + S + L +LG GAYG+ CS TGE V+IKK F R LREI +++ Sbjct: 40 PFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMR 99 Query: 65 HFKHENIITIFNIQRP--DSFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQT 121 F HEN++ + NI P + +F +VY++ LM D++ V+ S Q+L + H+QYF+YQ Sbjct: 100 FFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEESHMQYFVYQI 159 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 LR +K LH +NV HRDLKP+NL+ N +C+LK+ DFGL+R +D ++ +T+ Sbjct: 160 LRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSE----------LTD 209 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 YV TRWYR PE++L + YS A+D+WS GCI AE++ R+P+FPGR+ QL +I IG Sbjct: 210 YVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGK 269 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRV--NPKGIDLLQRMLVFDPAKRIT 299 P + +E A E + LP + + K+ P + N +GID L +M DP+KR T Sbjct: 270 PPA----SIVEHREALEKLNELP-DGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPT 324 Query: 300 AKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIF 352 A + L HPYL HD DEP P F + H + +L++ W +I Sbjct: 325 AADMLAHPYLAHLHDEEDEPTC----PCPFLWAHESTPMGVSELRRAFWADIV 373 >3RP9-A nrPDB Length = 458 Score = 307 bits (786), Expect = 5e-84, Method: Composition-based stats. Identities = 136/402 (33%), Positives = 197/402 (49%), Gaps = 55/402 (13%) Query: 1 MP-KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLR 58 MP + I ++++ L+G G+YG VC A K +VAIKKI F+ + R LR Sbjct: 42 MPRPHSDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILR 101 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-LSDDHIQYF 117 EI IL H++++ + +I P E F+E+Y++ E+ +D ++ T + L++ HI+ Sbjct: 102 EIAILNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTL 161 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS------- 170 +Y L VK +H + ++HRDLKP+N L+N +C +KVCDFGLAR +D NS Sbjct: 162 LYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPR 221 Query: 171 ----------EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-- 218 + +T +V TRWYRAPE++L Y+ A+DVWS GCI AEL Sbjct: 222 EDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMI 281 Query: 219 ---------RRPIFPGRD--------------------YRHQLLLIFGIIGTPHSDNDLR 249 R P+FPG R QL +IF I+GTP S+ D+ Sbjct: 282 KENVAYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTP-SEEDIE 340 Query: 250 CIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 +E A+ YI+ P L + FP + I LL+RMLVF+P KRIT E L HP+ Sbjct: 341 ALEKEDAKRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFF 400 Query: 310 QTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 + E F D + L+ EI Sbjct: 401 KEVRIAEVETNATEKVRLPFN-DWMN--MDEPQLRYAFVKEI 439 >3NIZ-A nrPDB Length = 311 Score = 306 bits (785), Expect = 6e-84, Method: Composition-based stats. Identities = 112/310 (36%), Positives = 162/310 (52%), Gaps = 21/310 (6%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP-FDKPLFALRTLREIKILKHF 66 + +Q +GEG YGVV A G IVA+K+I + +REI +LK Sbjct: 18 GLMEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLKEL 76 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ--MLSDDHIQYFIYQTLRA 124 H NI+++ ++ + + ++ E M+ DL +V+ L D I+ ++YQ LR Sbjct: 77 HHPNIVSLIDVIHSERC-----LTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRG 131 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 V H ++HRDLKP NLLINS+ LK+ DFGLAR T V Sbjct: 132 VAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPV----------RSYTHEVV 181 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 T WYRAP+V++ S KYS ++D+WS GCI AE+ +P+FPG QL IF I+GTP+ Sbjct: 182 TLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNP 241 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 + E P ++ + + P + P +GIDLL ML FDP KRI+A++A+ Sbjct: 242 REWPQVQELPLWKQRTFQV--FEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAM 299 Query: 305 EHPYLQTYHD 314 HPY + Sbjct: 300 NHPYFKDLDP 309 >6GU6-A nrPDB Length = 302 Score = 305 bits (781), Expect = 2e-83, Method: Composition-based stats. Identities = 109/307 (35%), Positives = 164/307 (53%), Gaps = 23/307 (7%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHE 69 D+ +GEG YGVV HK TG++VA+KKI ++ +REI +LK +H Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 66 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST----QMLSDDHIQYFIYQTLRAV 125 NI+++ ++ DS +Y+I E + DL + + + Q + ++ ++YQ L+ + Sbjct: 67 NIVSLQDVLMQDS-----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 121 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 H V+HRDLKP NLLI+ +K+ DFGLAR T V T Sbjct: 122 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI----------RVYTHEVVT 171 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 WYR+PEV+L SA+YS +D+WS G I AEL ++P+F G QL IF +GTP+++ Sbjct: 172 LWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNE 231 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 E ++Y + P + L ++ G+DLL +ML++DPAKRI+ K AL Sbjct: 232 VWP---EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 288 Query: 306 HPYLQTY 312 HPY Sbjct: 289 HPYFNDL 295 >4KRC-A nrPDB Length = 317 Score = 301 bits (770), Expect = 4e-82, Method: Composition-based stats. Identities = 104/314 (33%), Positives = 163/314 (51%), Gaps = 24/314 (7%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 SS F+ LG G Y V +K TG VA+K+++ + +REI ++K KHE Sbjct: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHE 63 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ-------MLSDDHIQYFIYQTL 122 NI+ ++++ N++ ++ E M DL + + ++ L + ++YF +Q L Sbjct: 64 NIVRLYDVI-----HTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + + H + ++HRDLKP NLLIN LK+ DFGLAR S Sbjct: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSE---------- 168 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 V T WYRAP+V++ S YS ++D+WSCGCILAE+ +P+FPG + QL LIF I+GTP Sbjct: 169 VVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTP 228 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKG--IDLLQRMLVFDPAKRITA 300 + + P+ I+ P + + + G +D L +L +P R++A Sbjct: 229 NESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA 288 Query: 301 KEALEHPYLQTYHD 314 K+AL HP+ Y+ Sbjct: 289 KQALHHPWFAEYYH 302 >1G3N-A nrPDB Length = 326 Score = 297 bits (760), Expect = 6e-81, Method: Composition-based stats. Identities = 112/335 (33%), Positives = 172/335 (51%), Gaps = 25/335 (7%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATH-KPTGEIVAIKKIE-PFDKPLFALRTLR 58 M K + ++ + +GEGAYG V A K G VA+K++ + L T+R Sbjct: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 Query: 59 EIKILKHFK---HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI---STQMLSDD 112 E+ +L+H + H N++ +F++ + ++ ++ E + DL + + + Sbjct: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE 120 Query: 113 HIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEP 172 I+ ++Q LR + LH V+HRDLKP N+L+ S+ +K+ DFGLARI Sbjct: 121 TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY---------- 170 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 Q +T V T WYRAPEV+L S+ Y+ +D+WS GCI AE+F R+P+F G QL Sbjct: 171 -SFQMALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 I +IG P ++ R + PR + KS A P+EK ++ G DLL + L F Sbjct: 229 GKILDVIGLPGEEDWPRDVALPRQAFHSKS-----AQPIEKFVTDIDELGKDLLLKCLTF 283 Query: 293 DPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPS 327 +PAKRI+A AL HPY Q + + P Sbjct: 284 NPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQ 318 >3N9X-A nrPDB Length = 432 Score = 296 bits (758), Expect = 1e-80, Method: Composition-based stats. Identities = 137/388 (35%), Positives = 205/388 (52%), Gaps = 46/388 (11%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP-FDKPLFALRTLREIKILKHF 66 ++ ++ +K L+G G+YG V A K T + VAIKK+ F+ + R LREI IL Sbjct: 23 HVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRL 82 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ-MLSDDHIQYFIYQTLRAV 125 K + II ++++ PD F+E+YI+ E+ +DL ++ T L+++HI+ +Y L Sbjct: 83 KSDYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIFLTEEHIKTILYNLLLGE 142 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIID------------ESAADNSEPT 173 +H S +IHRDLKP+N L+N +C +KVCDFGLAR I+ E+ Sbjct: 143 NFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNK 202 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-----------LRRPI 222 + +T +V TRWYRAPE++L Y++++D+WS GCI AEL R P+ Sbjct: 203 NLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPL 262 Query: 223 FPG-----------------RDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPM 265 FPG + R QL +IF IIGTP D DL+ I P +YIK P Sbjct: 263 FPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTED-DLKNINKPEVIKYIKLFPH 321 Query: 266 YPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIP 325 L++ +P ++ GI+LL+ ML F+P KRIT +AL+HPYL+ + E Sbjct: 322 RKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRK--KKLENFSTK 379 Query: 326 PSFFEFDHYKEALTTKDLKKLIWNEIFS 353 FD + L+ L+ + E+ S Sbjct: 380 KIILPFDDWM-VLSETQLRYIFLKEVQS 406 >4AU8-A nrPDB Length = 296 Score = 296 bits (757), Expect = 1e-80, Method: Composition-based stats. Identities = 114/311 (36%), Positives = 167/311 (53%), Gaps = 24/311 (7%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDK-PLFALRTLREIKILKHFKH 68 S ++ +GEG YG V A ++ T EIVA+K++ D LREI +LK KH Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 64 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST--QMLSDDHIQYFIYQTLRAVK 126 +NI+ + ++ D ++ ++ E DL + + L + ++ F++Q L+ + Sbjct: 65 KNIVRLHDVLHSD-----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 119 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H NV+HRDLKP NLLIN N +LK+ DFGLAR + V T Sbjct: 120 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPV----------RCYSAEVVTL 169 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELF-LRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 WYR P+V+ + YS ++D+WS GCI AEL RP+FPG D QL IF ++GTP + Sbjct: 170 WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE 229 Query: 246 NDLRCIESPRAREYIKSLPMYPA-APLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 + P + Y PMYPA L + P++N G DLLQ +L +P +RI+A+EAL Sbjct: 230 QWPSMTKLPDYKPY----PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEAL 285 Query: 305 EHPYLQTYHDP 315 +HPY + P Sbjct: 286 QHPYFSDFCPP 296 >1V0B-A nrPDB Length = 288 Score = 296 bits (757), Expect = 1e-80, Method: Composition-based stats. Identities = 113/304 (37%), Positives = 156/304 (51%), Gaps = 22/304 (7%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHE 69 + +GEG YGVV A + GE A+KKI + T+REI ILK KH Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS--TQMLSDDHIQYFIYQTLRAVKV 127 NI+ ++++ + ++ E + DL +++ L + F+ Q L + Sbjct: 61 NIVKLYDVI-----HTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAY 115 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H V+HRDLKP NLLIN +LK+ DFGLAR T V T W Sbjct: 116 CHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPV----------RKYTHEVVTLW 165 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 YRAP+V++ S KYS +D+WS GCI AE+ P+FPG QL+ IF I+GTP+S N Sbjct: 166 YRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNW 225 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 E P+ Y + +Y P E ++ GIDLL +ML DP +RITAK+ALEH Sbjct: 226 PNVTELPK---YDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHA 282 Query: 308 YLQT 311 Y + Sbjct: 283 YFKE 286 >3PG1-A nrPDB Length = 362 Score = 293 bits (749), Expect = 1e-79, Method: Composition-based stats. Identities = 121/359 (33%), Positives = 192/359 (53%), Gaps = 31/359 (8%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI----------EPFDKPLFALR 55 ++ + S + ++ + G+YG VC+ G VAIK++ R Sbjct: 17 LHAMQSPYTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKR 75 Query: 56 TLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQML--SDDH 113 LREI++L HF H NI+ + +I +++Y++ ELM+TDL +VI Q + S H Sbjct: 76 VLREIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQH 135 Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPT 173 IQYF+Y L + VLH + V+HRDL P N+L+ N D+ +CDF LAR Sbjct: 136 IQYFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLARE-----------D 184 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLL 233 + T YV RWYRAPE+++ +++ +D+WS GC++AE+F R+ +F G + +QL Sbjct: 185 TADANKTHYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLN 244 Query: 234 LIFGIIGTPHSDNDLRCIESPRAREYIK-SLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 I ++GTP + D+ SP AR+Y++ SL PA + P +P +DL+ +ML F Sbjct: 245 KIVEVVGTPKIE-DVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEF 303 Query: 293 DPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEI 351 +P +RI+ ++AL HPY ++ DP D EG F + D+ K+ E+ Sbjct: 304 NPQRRISTEQALRHPYFESLFDPLDLTEGLS-----ERFHFDESVTDVYDMHKIFTAEV 357 >3NIE-A nrPDB Length = 429 Score = 289 bits (739), Expect = 2e-78, Method: Composition-based stats. Identities = 135/393 (34%), Positives = 200/393 (50%), Gaps = 55/393 (13%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP-FDKPLFALRTLREIKILKHFK 67 + ++++K L+G G+YG V A K + VAIKK+ F+ + R LREI IL K Sbjct: 26 VPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLK 85 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ-MLSDDHIQYFIYQTLRAVK 126 + II + ++ P+ F+E+YI+ E+ +DL ++ T L++ H++ +Y L K Sbjct: 86 SDYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIFLTEQHVKTILYNLLLGEK 145 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESA---------------ADNSE 171 +H S +IHRDLKP+N L+N +C +K+CDFGLAR I+ Sbjct: 146 FIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPH 205 Query: 172 PTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF-----------LRR 220 + +T +V TRWYRAPE++L Y+ ++D+WS GCI AEL R Sbjct: 206 NKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRF 265 Query: 221 PIFPG-----------------RDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSL 263 P+FPG + R QL +IF +IGTP + DL+CI +YIK Sbjct: 266 PLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPP-EEDLKCITKQEVIKYIKLF 324 Query: 264 PMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPNDE---PE 320 P L K + ++ +GIDLL+ ML F+ KRIT +AL HPYL+ N E E Sbjct: 325 PTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKENLENFSTE 384 Query: 321 GEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 +P FD + L+ L+ + EI S Sbjct: 385 KIILP-----FDDWM-VLSETQLRYIFLKEIQS 411 >5EFQ-A nrPDB Length = 347 Score = 288 bits (736), Expect = 4e-78, Method: Composition-based stats. Identities = 111/326 (34%), Positives = 167/326 (51%), Gaps = 24/326 (7%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP-FDKPLFALRTLREIKILKHFKHE 69 F + ++GEG YG V A K TGE+VA+KK+ +K F + +REIKIL+ H+ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 70 NIITIFNIQRP-----DSFENFNEVYIIQELMQTDLHRVISTQM--LSDDHIQYFIYQTL 122 +II + I D ++ Y++ E M DL ++ + + +++HI+ F+ Q + Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 130 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + H N +HRD+K SN+L+N+ +K+ DFGLAR+ + T Sbjct: 131 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSE---------ESRPYTNK 181 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 V T WYR PE++L +Y+ A+DVWSCGCIL ELF ++PIF QL LI I G+P Sbjct: 182 VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSP 241 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 I+ P +K Y L + F + +DL ML DP+KR TA++ Sbjct: 242 CPAVWPDVIKLPYFNT-MKPKKQYRRK-LREEFVFIPAAALDLFDYMLALDPSKRCTAEQ 299 Query: 303 ALEHPYLQTYHDPNDEPEGEPIPPSF 328 AL+ +L+ EP P P Sbjct: 300 ALQCEFLRDV-----EPSKMPPPDLP 320 >1UA2-A nrPDB Length = 346 Score = 287 bits (734), Expect = 7e-78, Method: Composition-based stats. Identities = 109/324 (33%), Positives = 162/324 (50%), Gaps = 27/324 (8%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE----PFDKPLFALRTLREIKILKH 65 + ++ LGEG + V A K T +IVAIKKI+ K LREIK+L+ Sbjct: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ--MLSDDHIQYFIYQTLR 123 H NII + D+F + + + ++ + M+TDL +I +L+ HI+ ++ TL+ Sbjct: 69 LSHPNIIGLL-----DAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 ++ LH ++HRDLKP+NLL++ N LK+ DFGLA+ T V Sbjct: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGS----------PNRAYTHQV 173 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 TRWYRAPE++ + Y +D+W+ GCILAEL LR P PG QL IF +GTP Sbjct: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT 233 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 + P + +P PL +F +DL+Q + +F+P RITA +A Sbjct: 234 EEQWPDMCSLPD----YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA 289 Query: 304 LEHPYLQTYHDPNDEPEGEPIPPS 327 L+ Y P P + P+ Sbjct: 290 LKMKYFSNRPGPT--PGCQLPRPN 311 >5JN2-A nrPDB Length = 525 Score = 284 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 83/314 (26%), Positives = 141/314 (44%), Gaps = 53/314 (16%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHF 66 S ++ + +LG+G++G V K TG+ A+K I + LRE+++LK Sbjct: 65 FSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL 124 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRA 124 H NI+ ++ FE+ Y++ E+ +IS + S+ I Q L Sbjct: 125 DHPNIMKLYEF-----FEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSG 179 Query: 125 VKVLHGSNVIHRDLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 + +H + ++HRDLKP NLL+ + + ++++ DFGL+ + S M + Sbjct: 180 ITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEAS-----------KKMKD 228 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 + T +Y APEV+ Y DVWS G IL L P F G + L + Sbjct: 229 KIGTAYYIAPEVL--HGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKV------ 280 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 +Y LP + +V+ DL+++ML + P+ RI+A+ Sbjct: 281 -------------EKGKYTFELPQ---------WKKVSESAKDLIRKMLTYVPSMRISAR 318 Query: 302 EALEHPYLQTYHDP 315 +AL+H ++QTY Sbjct: 319 DALDHEWIQTYTKE 332 >4NST-A nrPDB Length = 351 Score = 284 bits (727), Expect = 4e-77, Method: Composition-based stats. Identities = 109/348 (31%), Positives = 175/348 (50%), Gaps = 21/348 (6%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP-FDKPLFALRTLREIKILKHFKHE 69 F + ++GEG YG V A K TGE+VA+KK+ +K F + +REIKIL+ H Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 70 NIITIFNIQRP-----DSFENFNEVYIIQELMQTDLHRVISTQM--LSDDHIQYFIYQTL 122 +++ + I D ++ Y++ E M DL ++ + + S+DHI+ F+ Q + Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLM 132 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 ++ H N +HRD+K SN+L+N++ +K+ DFGLAR+ + + T Sbjct: 133 EGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSE---------ESRPYTNK 183 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 V T WYR PE++L +Y+ A+DVWSCGCIL ELF ++PIF QL LI + G+P Sbjct: 184 VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSP 243 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 I+ P +K Y L + F + +DLL ML DP+KR TA++ Sbjct: 244 CPAVWPDVIKLPYFNT-MKPKKQYRRR-LREEFSFIPSAALDLLDHMLTLDPSKRCTAEQ 301 Query: 303 ALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNE 350 L+ +L+ P +P + + + + ++ E Sbjct: 302 TLQSDFLKDVELSKMAP--PDLPHWQDCHELWSKKRRRQRQSGVVVEE 347 >3NCG-A nrPDB Length = 486 Score = 284 bits (726), Expect = 5e-77, Method: Composition-based stats. Identities = 91/348 (26%), Positives = 148/348 (42%), Gaps = 54/348 (15%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKIL 63 + + + +LG+G++G V + T + A+K I K LRE+++L Sbjct: 16 FQGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELL 75 Query: 64 KHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQT 121 K H NI+ +F I E+ + YI+ EL +I + S+ I Q Sbjct: 76 KKLDHPNIMKLFEI-----LEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQV 130 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 + +H N++HRDLKP N+L+ S +CD+K+ DFGL+ Q + Sbjct: 131 FSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQ-----------QNTK 179 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGI 238 M + + T +Y APEV+ Y DVWS G IL L P F G++ L + Sbjct: 180 MKDRIGTAYYIAPEVL--RGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV--- 234 Query: 239 IGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI 298 +Y LP + ++ DL+++ML F P+ RI Sbjct: 235 ----------------ETGKYAFDLPQWRT---------ISDDAKDLIRKMLTFHPSLRI 269 Query: 299 TAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKL 346 TA + LEHP++Q Y ++ P +P + ++ K L + Sbjct: 270 TATQCLEHPWIQKYS--SETPTISDLPSLESAMTNIRQFQAEKKLAQA 315 >2I6L-A nrPDB Length = 320 Score = 284 bits (726), Expect = 5e-77, Method: Composition-based stats. Identities = 119/323 (36%), Positives = 180/323 (55%), Gaps = 20/323 (6%) Query: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 +++ S + LG G G+V SA + VAIKKI D P LREIKI++ Sbjct: 7 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTD-PQSVKHALREIKIIRRL 65 Query: 67 KHENIITIFNIQRP---------DSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYF 117 H+NI+ +F I P S N VYI+QE M+TDL V+ L ++H + F Sbjct: 66 DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLF 125 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 +YQ LR +K +H +NV+HRDLKP+NL IN + LK+ DFGLARI+D + Sbjct: 126 MYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPH-------YSHK 178 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 ++E + T+WYR+P ++L+ Y++A+D+W+ GCI AE+ + +F G Q+ LI Sbjct: 179 GHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLIL 238 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAK 296 I H ++ + YI++ P PL ++ P ++ + +D L+++L F P Sbjct: 239 ESIPVVHEEDRQELLSVIPV--YIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMD 296 Query: 297 RITAKEALEHPYLQTYHDPNDEP 319 R+TA+EAL HPY+ Y P DEP Sbjct: 297 RLTAEEALSHPYMSIYSFPMDEP 319 >4AGU-A nrPDB Length = 311 Score = 282 bits (722), Expect = 1e-76, Method: Composition-based stats. Identities = 103/325 (31%), Positives = 162/325 (49%), Gaps = 19/325 (5%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKK-IEPFDKPLFALRTLREIKILKHFKHE 69 ++ +GEG+YGVV ++ TG+IVAIKK +E D P+ LREI++LK KH Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVISTQM-LSDDHIQYFIYQTLRAVKV 127 N++ + + F ++++ E LH + Q + + ++ +QTL+AV Sbjct: 63 NLVNLLEV-----FRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNF 117 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H N IHRD+KP N+LI + +K+CDFG AR++ TG + VATRW Sbjct: 118 CHKHNCIHRDVKPENILITKHSVIKLCDFGFARLL----------TGPSDYYDDEVATRW 167 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 YR+PE+++ +Y +DVW+ GC+ AEL P++PG+ QL LI +G + Sbjct: 168 YRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQ 227 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 + P PLE FP ++ + LL+ L DP +R+T ++ L HP Sbjct: 228 QVFSTNQYFSGVKIPDPE-DMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHP 286 Query: 308 YLQTYHDPNDEPEGEPIPPSFFEFD 332 Y + + D + P F Sbjct: 287 YFENIREIEDLAKEHDKPAENLYFQ 311 >3DFA-A nrPDB Length = 286 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 87/314 (27%), Positives = 137/314 (43%), Gaps = 52/314 (16%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKIL 63 + + + +LG+G++G V + T + A+K I K LRE+++L Sbjct: 16 FQGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELL 75 Query: 64 KHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQT 121 K H NI+ +F I E+ + YI+ EL +I + S+ I Q Sbjct: 76 KKLDHPNIMKLFEI-----LEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQV 130 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 + +H N++HRDLKP N+L+ S +CD+K+ DFGL+ Q + Sbjct: 131 FSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQ-----------QNTK 179 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGI 238 M + + T +Y APEV+ Y DVWS G IL L P F G++ L + Sbjct: 180 MKDRIGTAYYIAPEVL--RGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV--- 234 Query: 239 IGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI 298 +Y LP + ++ DL+++ML F P+ RI Sbjct: 235 ----------------ETGKYAFDLPQWRT---------ISDDAKDLIRKMLTFHPSLRI 269 Query: 299 TAKEALEHPYLQTY 312 TA + LEHP++Q Y Sbjct: 270 TATQCLEHPWIQKY 283 >4MVF-A nrPDB Length = 506 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 81/308 (26%), Positives = 136/308 (44%), Gaps = 52/308 (16%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 + + + LG+G YG V K T ++ AIK+ E D+ R +EI+I+K H Sbjct: 55 LEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKE-EKKDRLKNINRFFQEIEIMKKLDH 113 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQT--DLHRVISTQMLSDDHIQYFIYQTLRAVK 126 NI+ ++ +++EN N +Y+I EL +I ++ + + Q A+ Sbjct: 114 PNIVKLY-----ETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIF 168 Query: 127 VLHGSNVIHRDLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 LH N++HRDLKP N L N + LK+ DFGL++ + G T Sbjct: 169 YLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNL-----------GTGEFTTTKA 217 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 T +Y AP+V+ KY + D+WS G I+ L P F G Sbjct: 218 GTPYYVAPQVL--DGKYDKKCDIWSSGVIMYTLLCGYPPFYG------------------ 257 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 D D ++ + E+ E + ++ +L+ ++L ++P +R T +EA Sbjct: 258 -DTDNEVLKKVKKGEFCF---------YENDWGSISSDAKNLITKLLTYNPNERCTIEEA 307 Query: 304 LEHPYLQT 311 L HP++ Sbjct: 308 LNHPWITQ 315 >4BGQ-A nrPDB Length = 304 Score = 278 bits (712), Expect = 2e-75, Method: Composition-based stats. Identities = 105/309 (33%), Positives = 170/309 (55%), Gaps = 18/309 (5%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHF 66 N+ + F++ ++GEGAYGVV HK T EIVAIKK + + TLRE+K+L+ Sbjct: 9 NVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTL 68 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST--QMLSDDHIQYFIYQTLRA 124 K ENI+ + ++F ++Y++ E ++ ++ ++ + + ++ +IYQ ++A Sbjct: 69 KQENIVEL-----KEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKA 123 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + H ++++HRD+KP NLLI+ N LK+CDFG AR + E G + E VA Sbjct: 124 IHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSE---------GNNANYDEEVA 174 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 TRWYR+PE++L A Y +++D+WS GCIL EL +P+FPG QL I ++G S Sbjct: 175 TRWYRSPELLLG-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPS 233 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 + +PR +P + + +N +DL++ +L DPA R ++ L Sbjct: 234 EQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCL 293 Query: 305 EHPYLQTYH 313 HP QT Sbjct: 294 NHPTFQTQR 302 >2W96-B nrPDB Length = 306 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 106/318 (33%), Positives = 162/318 (50%), Gaps = 27/318 (8%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFK- 67 +S ++ + +G GAYG V A +G VA+K + P + + T+RE+ +L+ + Sbjct: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEA 62 Query: 68 --HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST---QMLSDDHIQYFIYQTL 122 H N++ + ++ + +V ++ E + DL + L + I+ + Q L Sbjct: 63 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 R + LH + ++HRDLKP N+L+ S +K+ DFGLARI Q + Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-----------SYQMALDPV 171 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 V T WYRAPEV+L S Y+ +D+WS GCI AE+F R+P+F G QL IF +IG P Sbjct: 172 VVTLWYRAPEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 230 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 D+ R + PR + P P++ + P + G LL ML F+P KRI+A Sbjct: 231 PEDDWPRDVSLPRG-----AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR 285 Query: 303 ALEHPYLQTYHDPNDEPE 320 AL+H YL H PE Sbjct: 286 ALQHSYL---HKDEGNPE 300 >3MIA-A nrPDB Length = 351 Score = 277 bits (710), Expect = 4e-75, Method: Composition-based stats. Identities = 93/313 (29%), Positives = 155/313 (49%), Gaps = 12/313 (3%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKK-IEPFDKPLFALRTLREIKILKHFKHE 69 S ++ + +G+G +G V A H+ TG+ VA+KK + +K F + LREIKIL+ KHE Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Query: 70 NIITIFNIQRPDSF---ENFNEVYIIQELMQTDLHRVISTQ--MLSDDHIQYFIYQTLRA 124 N++ + I R + +Y++ + + DL ++S + I+ + L Sbjct: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + +H + ++HRD+K +N+LI + LK+ DFGLAR + Q + T V Sbjct: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK------NSQPNRYTNRVV 190 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 T WYR PE++L Y +D+W GCI+AE++ R PI G +HQL LI + G+ Sbjct: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 + + +P +DL+ ++LV DPA+RI + +AL Sbjct: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 Query: 305 EHPYLQTYHDPND 317 H + + P+D Sbjct: 311 NHDFFWSDPMPSD 323 >3MA6-A nrPDB Length = 298 Score = 277 bits (710), Expect = 4e-75, Method: Composition-based stats. Identities = 83/314 (26%), Positives = 141/314 (44%), Gaps = 53/314 (16%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHF 66 S ++ + +LG+G++G V K TG+ A+K I + LRE+++LK Sbjct: 30 FSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQL 89 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRA 124 H NI+ ++ FE+ Y++ E+ +IS + S+ I Q L Sbjct: 90 DHPNIMKLYEF-----FEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSG 144 Query: 125 VKVLHGSNVIHRDLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 + +H + ++HRDLKP NLL+ + + ++++ DFGL+ + S M + Sbjct: 145 ITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEAS-----------KKMKD 193 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 + T +Y APEV+ Y DVWS G IL L P F G + L + Sbjct: 194 KIGTAYYIAPEVL--HGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKV------ 245 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 +Y LP + +V+ DL+++ML + P+ RI+A+ Sbjct: 246 -------------EKGKYTFELPQ---------WKKVSESAKDLIRKMLTYVPSMRISAR 283 Query: 302 EALEHPYLQTYHDP 315 +AL+H ++QTY Sbjct: 284 DALDHEWIQTYTKE 297 >4BBM-A nrPDB Length = 331 Score = 276 bits (705), Expect = 1e-74, Method: Composition-based stats. Identities = 94/303 (31%), Positives = 155/303 (51%), Gaps = 19/303 (6%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKK-IEPFDKPLFALRTLREIKILKHFKHE 69 ++ L+GEG+YG+V +K TG IVAIKK +E D + +REIK+LK +HE Sbjct: 25 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 84 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS--TQMLSDDHIQYFIYQTLRAVKV 127 N++ + + + Y++ E + + + L +Q +++Q + + Sbjct: 85 NLVNLLEVCKK-----KKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGF 139 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H N+IHRD+KP N+L++ + +K+CDFG AR + + VATRW Sbjct: 140 CHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTL----------AAPGEVYDDEVATRW 189 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 YRAPE+++ KY +A+DVW+ GC++ E+F+ P+FPG QL I +G + Sbjct: 190 YRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQ 249 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 ++P + PLE+ +P+++ IDL ++ L DP KR E L H Sbjct: 250 ELFNKNPVFAGVRLPE-IKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHD 308 Query: 308 YLQ 310 + Q Sbjct: 309 FFQ 311 >5G6V-A nrPDB Length = 324 Score = 276 bits (705), Expect = 1e-74, Method: Composition-based stats. Identities = 98/299 (32%), Positives = 151/299 (50%), Gaps = 19/299 (6%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 + LGEG Y V K T +VA+K+I + +RE+ +LK KH NI+ Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIV 63 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST--QMLSDDHIQYFIYQTLRAVKVLHG 130 T+ +I + ++ E + DL + + +++ +++ F++Q LR + H Sbjct: 64 TLHDII-----HTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHR 118 Query: 131 SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRA 190 V+HRDLKP NLLIN +LK+ DFGLAR V T WYR Sbjct: 119 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNE----------VVTLWYRP 168 Query: 191 PEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRC 250 P+++L S YS +D+W GCI E+ RP+FPG QL IF I+GTP + Sbjct: 169 PDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGI 228 Query: 251 IESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 + + + Y + P Y A L PR++ G DLL ++L F+ RI+A++A++HP+ Sbjct: 229 LSNEEFKTY--NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >3LIJ-A nrPDB Length = 494 Score = 271 bits (694), Expect = 2e-73, Method: Composition-based stats. Identities = 89/310 (28%), Positives = 134/310 (43%), Gaps = 52/310 (16%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHF 66 ++S +Q LG GAYG V K T AIK I + L E+ +LK Sbjct: 34 HLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLL 93 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRA 124 H NI+ +++ FE+ Y++ E + +I ++ I Q L Sbjct: 94 DHPNIMKLYDF-----FEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSG 148 Query: 125 VKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 V LH N++HRDLKP NLL+ S + +K+ DFGL+ + + Q M E Sbjct: 149 VTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFE-----------NQKKMKE 197 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 + T +Y APEV+ KY DVWS G IL L P F G+ + L + Sbjct: 198 RLGTAYYIAPEVL--RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKV------ 249 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 +Y P + V+ DL+++ML FD +RI+A+ Sbjct: 250 -------------EKGKYTFDSPE---------WKNVSEGAKDLIKQMLQFDSQRRISAQ 287 Query: 302 EALEHPYLQT 311 +ALEHP+++ Sbjct: 288 QALEHPWIKE 297 >3HZT-A nrPDB Length = 467 Score = 270 bits (691), Expect = 6e-73, Method: Composition-based stats. Identities = 88/309 (28%), Positives = 134/309 (43%), Gaps = 53/309 (17%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKH 65 +S +Q LG GAYG V K TG AIK I+ + L E+ +LK Sbjct: 1 GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 60 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLR 123 H NI+ ++ FE+ Y++ E+ + +I Q S+ + Q L Sbjct: 61 LDHPNIMKLYEF-----FEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLS 115 Query: 124 AVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 LH N++HRDLKP NLL+ S + +K+ DFGL+ + M Sbjct: 116 GTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGG-----------KMK 164 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 E + T +Y APEV+ KY DVWSCG IL L P F G+ + L + Sbjct: 165 ERLGTAYYIAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRV----- 217 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 ++ P + +V+ + L++ ML ++P+KRI+A Sbjct: 218 --------------EKGKFSFDPP---------DWTQVSDEAKQLVKLMLTYEPSKRISA 254 Query: 301 KEALEHPYL 309 +EAL HP++ Sbjct: 255 EEALNHPWI 263 >2VN9-A nrPDB Length = 301 Score = 270 bits (690), Expect = 8e-73, Method: Composition-based stats. Identities = 87/307 (28%), Positives = 136/307 (44%), Gaps = 50/307 (16%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFK 67 ++ ++QL LG+GA+ VV PTG+ A K I + RE +I + K Sbjct: 2 MTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLK 61 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H NI+ + + + F Y++ +L+ +++ + S+ + I Q L +V Sbjct: 62 HPNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESV 116 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 H + ++HRDLKP NLL+ S +K+ DFGLA E G Q + Sbjct: 117 NHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA----------IEVQGDQQAWFGF 166 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 T Y +PEV+ Y + +D+W+CG IL L + P F D Sbjct: 167 AGTPGYLSPEVLRKD-PYGKPVDMWACGVILYILLVGYPPFWDED--------------- 210 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 R + +A Y P + V P+ DL+ +ML +PAKRITA E Sbjct: 211 ----QHRLYQQIKAGAYDFPSPEWDT---------VTPEAKDLINKMLTINPAKRITASE 257 Query: 303 ALEHPYL 309 AL+HP++ Sbjct: 258 ALKHPWI 264 >3DXN-A nrPDB Length = 287 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 88/309 (28%), Positives = 134/309 (43%), Gaps = 53/309 (17%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKH 65 +S +Q LG GAYG V K TG AIK I+ + L E+ +LK Sbjct: 18 GLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQ 77 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLR 123 H NI+ ++ FE+ Y++ E+ + +I Q S+ + Q L Sbjct: 78 LDHPNIMKLYEF-----FEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLS 132 Query: 124 AVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 LH N++HRDLKP NLL+ S + +K+ DFGL+ + M Sbjct: 133 GTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGG-----------KMK 181 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 E + T +Y APEV+ KY DVWSCG IL L P F G+ + L + Sbjct: 182 ERLGTAYYIAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRV----- 234 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 ++ P + +V+ + L++ ML ++P+KRI+A Sbjct: 235 --------------EKGKFSFDPP---------DWTQVSDEAKQLVKLMLTYEPSKRISA 271 Query: 301 KEALEHPYL 309 +EAL HP++ Sbjct: 272 EEALNHPWI 280 >2BDW-A nrPDB Length = 362 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 82/307 (26%), Positives = 136/307 (44%), Gaps = 51/307 (16%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFK 67 S ++ +K LG+GA+ VV HK TG A K I + RE +I + + Sbjct: 27 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQ 86 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H NI+ + + + +SF Y++ +L+ +++ + S+ + I Q L ++ Sbjct: 87 HPNIVRLHDSIQEESFH-----YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESI 141 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 H + ++HR+LKP NLL+ S +K+ DFGLA +++S A + + Sbjct: 142 AYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWH-----------GF 190 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 T Y +PEV+ YS+ +D+W+CG IL L + P F D I Sbjct: 191 AGTPGYLSPEVL-KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI------- 242 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 +A Y P + V P+ L+ ML +P KRITA + Sbjct: 243 ------------KAGAYDYPSPEWDT---------VTPEAKSLIDSMLTVNPKKRITADQ 281 Query: 303 ALEHPYL 309 AL+ P++ Sbjct: 282 ALKVPWI 288 >5FG8-A nrPDB Length = 285 Score = 266 bits (681), Expect = 8e-72, Method: Composition-based stats. Identities = 85/308 (27%), Positives = 132/308 (42%), Gaps = 50/308 (16%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHF 66 S ++ +K LG+GA+ +V K TG A K I + RE +I + Sbjct: 11 RFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKL 70 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRA 124 H NI+ + DS + N Y++ +L+ +++ + S+ + I Q L + Sbjct: 71 HHPNIVRLH-----DSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILES 125 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 V H + V+HRDLKP NLL+ S +K+ DFGLA E G Sbjct: 126 VNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLA----------IEVQGDHQAWFG 175 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 + T Y +PEV+ Y +++D+W+CG IL L + P F D I Sbjct: 176 FAGTPGYLSPEVL-KKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI------ 228 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 +A Y P + V P+ +L+ +ML +P KRITA Sbjct: 229 -------------KAGAYDYPSPEWDT---------VTPEAKNLINQMLTVNPNKRITAA 266 Query: 302 EALEHPYL 309 EAL+HP++ Sbjct: 267 EALKHPWI 274 >4E7W-A nrPDB Length = 394 Score = 266 bits (680), Expect = 1e-71, Method: Composition-based stats. Identities = 105/359 (29%), Positives = 178/359 (49%), Gaps = 43/359 (11%) Query: 2 PKRIVYNISSD----------FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPL 51 P +++ ++SD + ++G G++GVV A + E VAIKK+ + Sbjct: 21 PNKVIKVLASDGKTGEQREIAYTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFK 79 Query: 52 FALRTLREIKILKHFKHENIITIF------NIQRPDSFENFNEVYIIQELMQTDLHRVIS 105 RE++I++ KH N++ + ++ + F N Y+ + + + H Sbjct: 80 N-----RELQIMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKL 134 Query: 106 TQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINS-NCDLKVCDFGLARIIDE 164 Q + I+ ++YQ LR++ +H + HRD+KP NLL++ + LK+ DFG A+I+ Sbjct: 135 KQTMPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIA 194 Query: 165 SAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFP 224 + S Y+ +R+YRAPE++ + Y+ +D+WS GC++AEL +P+FP Sbjct: 195 GEPNVS-----------YICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFP 243 Query: 225 GRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMF-PRVNPKGI 283 G QL+ I ++GTP + +P E+ P P K+F PR P I Sbjct: 244 GESGIDQLVEIIKVLGTPSREQIKTM--NPNYMEH--KFPQIRPHPFSKVFRPRTPPDAI 299 Query: 284 DLLQRMLVFDPAKRITAKEALEHPYLQTYH-DPNDEPEGEPIPPSFFEFDHYKEALTTK 341 DL+ R+L + P+ R+TA EAL HP+ P G +PP F+ KE L+ + Sbjct: 300 DLISRLLEYTPSARLTAIEALCHPFFDELRTGEARMPNGRELPPL---FNWTKEELSVR 355 >5AIR-A nrPDB Length = 430 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 104/326 (31%), Positives = 167/326 (51%), Gaps = 31/326 (9%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 + ++G G++GVV A +GE+VAIKK+ + RE++I++ H NI+ Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-----RELQIMRKLDHCNIV 120 Query: 73 TIFNIQRPDSFENFNEVYI--IQELMQTDLHRVIS-----TQMLSDDHIQYFIYQTLRAV 125 + E +EVY+ + + + ++RV Q L +++ ++YQ R++ Sbjct: 121 RLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 179 Query: 126 KVLHGSNVIHRDLKPSNLLINSN-CDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 +H + HRD+KP NLL++ + LK+CDFG A+ + + S Y+ Sbjct: 180 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVS-----------YIC 228 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 +R+YRAPE++ + Y+ ++DVWS GC+LAEL L +PIFPG QL+ I ++GTP Sbjct: 229 SRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR 288 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMF-PRVNPKGIDLLQRMLVFDPAKRITAKEA 303 + +P E+ P A P K+F PR P+ I L R+L + P R+T EA Sbjct: 289 EQIREM--NPNYTEF--KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEA 344 Query: 304 LEHPYLQTYHDPNDE-PEGEPIPPSF 328 H + DPN + P G P F Sbjct: 345 CAHSFFDELRDPNVKLPNGRDTPALF 370 >2JC6-A nrPDB Length = 334 Score = 264 bits (674), Expect = 5e-71, Method: Composition-based stats. Identities = 84/312 (26%), Positives = 134/312 (42%), Gaps = 50/312 (16%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKI 62 K+ +I F+ K LG GA+ V A K TG++ A+K I EI + Sbjct: 14 KKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAV 73 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQ 120 L+ KHENI+ + +I +E+ N +Y++ +L+ R++ ++ I Q Sbjct: 74 LRKIKHENIVALEDI-----YESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQ 128 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 L AV LH ++HRDLKP NLL + + + DFGL+++ G+ Sbjct: 129 VLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-----------EGKGD 177 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 M+ T Y APEV+ YS+A+D WS G I L P F Sbjct: 178 VMSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVIAYILLCGYPPF-------------- 222 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 + +ND + E EY P + ++ D ++ ++ DP KR Sbjct: 223 -----YDENDSKLFEQILKAEYEFDSPYWD---------DISDSAKDFIRNLMEKDPNKR 268 Query: 298 ITAKEALEHPYL 309 T ++A HP++ Sbjct: 269 YTCEQAARHPWI 280 >2V7O-A nrPDB Length = 336 Score = 264 bits (674), Expect = 5e-71, Method: Composition-based stats. Identities = 84/308 (27%), Positives = 137/308 (44%), Gaps = 50/308 (16%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHF 66 + D+QL LG+GA+ VV K + A K I + RE +I + Sbjct: 28 RFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLL 87 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRA 124 KH NI+ + + + F Y++ +L+ +++ + S+ + I+Q L + Sbjct: 88 KHPNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADASHCIHQILES 142 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 V +H +++HRDLKP NLL+ S C +K+ DFGLA E G+Q Sbjct: 143 VNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA----------IEVQGEQQAWFG 192 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 + T Y +PEV+ Y + +D+W+CG IL L + P F D Sbjct: 193 FAGTPGYLSPEVLRKD-PYGKPVDIWACGVILYILLVGYPPFWDED-------------- 237 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 + + +A Y P + V P+ +L+ +ML +PAKRITA Sbjct: 238 -----QHKLYQQIKAGAYDFPSPEWDT---------VTPEAKNLINQMLTINPAKRITAD 283 Query: 302 EALEHPYL 309 +AL+HP++ Sbjct: 284 QALKHPWV 291 >3KK8-A nrPDB Length = 284 Score = 263 bits (673), Expect = 8e-71, Method: Composition-based stats. Identities = 82/307 (26%), Positives = 136/307 (44%), Gaps = 51/307 (16%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFK 67 S ++ +K LG+GA+ VV HK TG A K I + RE +I + + Sbjct: 4 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQ 63 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H NI+ + + + +SF Y++ +L+ +++ + S+ + I Q L ++ Sbjct: 64 HPNIVRLHDSIQEESFH-----YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESI 118 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 H + ++HR+LKP NLL+ S +K+ DFGLA +++S A + + Sbjct: 119 AYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWH-----------GF 167 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 T Y +PEV+ YS+ +D+W+CG IL L + P F D I Sbjct: 168 AGTPGYLSPEVL-KKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI------- 219 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 +A Y P + V P+ L+ ML +P KRITA + Sbjct: 220 ------------KAGAYDYPSPEWDT---------VTPEAKSLIDSMLTVNPKKRITADQ 258 Query: 303 ALEHPYL 309 AL+ P++ Sbjct: 259 ALKVPWI 265 >4FG9-A nrPDB Length = 320 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 82/312 (26%), Positives = 135/312 (43%), Gaps = 50/312 (16%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKI 62 + +I + + +LG GA+ V A K T ++VAIK I EI + Sbjct: 10 WKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAV 69 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQ 120 L KH NI+ + D +E+ +Y+I +L+ R++ ++ I+Q Sbjct: 70 LHKIKHPNIVAL-----DDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQ 124 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLL---INSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 L AVK LH ++HRDLKP NLL ++ + + + DFGL+++ D + Sbjct: 125 VLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSV---------- 174 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 ++ T Y APEV+ YS+A+D WS G I L P F Sbjct: 175 -LSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVIAYILLCGYPPF-------------- 218 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 + +ND + E EY P + ++ D ++ ++ DP KR Sbjct: 219 -----YDENDAKLFEQILKAEYEFDSPYWD---------DISDSAKDFIRHLMEKDPEKR 264 Query: 298 ITAKEALEHPYL 309 T ++AL+HP++ Sbjct: 265 FTCEQALQHPWI 276 >5U6Y-A nrPDB Length = 461 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 88/304 (28%), Positives = 130/304 (42%), Gaps = 50/304 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENI 71 +QL LG+GA+ VV G+ A K I + RE +I + KH NI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 + + DS Y+I +L+ +++ + S+ + I Q L AV H Sbjct: 62 VRLH-----DSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 116 Query: 130 GSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 V+HRDLKP NLL+ S +K+ DFGLA E G+Q + T Sbjct: 117 QMGVVHRDLKPENLLLASKLKGAAVKLADFGLA----------IEVEGEQQAWFGFAGTP 166 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y +PEV+ Y + +D+W+CG IL L + P F D Sbjct: 167 GYLSPEVLRKD-PYGKPVDLWACGVILYILLVGYPPFWDED------------------- 206 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 R + +A Y P + V P+ DL+ +ML +P+KRITA EAL+H Sbjct: 207 QHRLYQQIKAGAYDFPSPEWDT---------VTPEAKDLINKMLTINPSKRITAAEALKH 257 Query: 307 PYLQ 310 P++ Sbjct: 258 PWIS 261 >3GC0-A nrPDB Length = 329 Score = 261 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 102/308 (33%), Positives = 155/308 (50%), Gaps = 26/308 (8%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHE 69 ++ + LGEG YG V A T E VAIK+I ++ +RE+ +LK +H Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHR 93 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-LSDDHIQYFIYQTLRAVKVL 128 NII + ++ + + +++I E + DL + + +S I+ F+YQ + V Sbjct: 94 NIIELKSVI-----HHNHRLHLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNFC 148 Query: 129 HGSNVIHRDLKPSNLLIN-----SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 H +HRDLKP NLL++ LK+ DFGLAR T + Sbjct: 149 HSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPI----------RQFTHEI 198 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 T WYR PE++L S YS ++D+WS CI AE+ ++ P+FPG QL IF ++G P Sbjct: 199 ITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPD 258 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMF-PRVNPKGIDLLQRMLVFDPAKRITAKE 302 P ++ +S P + L+++ ++ +G+DLL ML DP KRI+AK Sbjct: 259 DTTWPGVTALP---DWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKN 315 Query: 303 ALEHPYLQ 310 ALEHPY Sbjct: 316 ALEHPYFS 323 >3BHH-A nrPDB Length = 295 Score = 261 bits (667), Expect = 3e-70, Method: Composition-based stats. Identities = 86/307 (28%), Positives = 134/307 (43%), Gaps = 50/307 (16%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFK 67 ++ ++QL +G+GA+ VV TG A K I + RE +I + K Sbjct: 2 MTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLK 61 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H NI+ + + + F Y++ +L+ +++ + S+ + I Q L AV Sbjct: 62 HSNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAV 116 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 H V+HRDLKP NLL+ S C +K+ DFGLA E G Q + Sbjct: 117 LHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA----------IEVQGDQQAWFGF 166 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 T Y +PEV+ Y + +D+W+CG IL L + P F D Sbjct: 167 AGTPGYLSPEVL-RKEAYGKPVDIWACGVILYILLVGYPPFWDED--------------- 210 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 + + +A Y P + V P+ +L+ +ML +PAKRITA E Sbjct: 211 ----QHKLYQQIKAGAYDFPSPEWDT---------VTPEAKNLINQMLTINPAKRITAHE 257 Query: 303 ALEHPYL 309 AL+HP++ Sbjct: 258 ALKHPWV 264 >2VZ6-A nrPDB Length = 313 Score = 261 bits (666), Expect = 5e-70, Method: Composition-based stats. Identities = 89/308 (28%), Positives = 131/308 (42%), Gaps = 50/308 (16%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFK 67 S +QL LG+GA+ VV G+ A K I + RE +I + K Sbjct: 20 FQSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLK 79 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H NI+ + DS Y+I +L+ +++ + S+ + I Q L AV Sbjct: 80 HPNIVRLH-----DSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAV 134 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 H V+HRDLKP NLL+ S +K+ DFGLA E G+Q + Sbjct: 135 LHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA----------IEVEGEQQAWFGF 184 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 T Y +PEV+ Y + +D+W+CG IL L + P F D Sbjct: 185 AGTPGYLSPEVLRKD-PYGKPVDLWACGVILYILLVGYPPFWDED--------------- 228 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 R + +A Y P + V P+ DL+ +ML +P+KRITA E Sbjct: 229 ----QHRLYQQIKAGAYDFPSPEWDT---------VTPEAKDLINKMLTINPSKRITAAE 275 Query: 303 ALEHPYLQ 310 AL+HP++ Sbjct: 276 ALKHPWIS 283 >5ES1-A nrPDB Length = 328 Score = 261 bits (666), Expect = 5e-70, Method: Composition-based stats. Identities = 72/346 (20%), Positives = 133/346 (38%), Gaps = 51/346 (14%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHE 69 +++L +G+G + V A H TG VAIK I+ P + RE++I+K H Sbjct: 15 GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHP 74 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ +F + E +Y++ E ++S + + + Q + AV Sbjct: 75 NIVKLFEVI-----ETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHY 129 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H N++HRDLK NLL+++ ++K+ DFG + + + + + Sbjct: 130 CHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGS-----------KLDTFCGSPP 178 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APE+ +D+WS G IL L F G + + Sbjct: 179 YAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKEL---------------- 222 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 R +P Y + E + L+R LV +PAKR T ++ ++ Sbjct: 223 -----RERVLRGKYRVPFYMSTDCESI-----------LRRFLVLNPAKRCTLEQIMKDK 266 Query: 308 YLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 ++ ++ + F + + + ++ I + S Sbjct: 267 WINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTS 312 >4YZB-A nrPDB Length = 491 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 81/329 (24%), Positives = 142/329 (43%), Gaps = 53/329 (16%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHF 66 S ++ + +LG+G++G V K TG+ A+K I + L+E+++LK Sbjct: 28 FSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKL 87 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRA 124 H NI+ ++ FE+ Y++ E+ +IS + S+ I Q L Sbjct: 88 DHPNIMKLYEF-----FEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSG 142 Query: 125 VKVLHGSNVIHRDLKPSNLLIN---SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 + +H + ++HRDLKP NLL+ + ++++ DFGL+ + + M + Sbjct: 143 ITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFEST-----------KKMKD 191 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 + T +Y APEV+ Y DVWS G IL L P F G + L + Sbjct: 192 KIGTAYYIAPEVL--HGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKV------ 243 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 ++ LP + +V+ DL+++ML + P RI+A+ Sbjct: 244 -------------EKGKFTFDLPQ---------WKKVSEPAKDLIRKMLAYVPTMRISAR 281 Query: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFE 330 +ALEH +L+T D + + + Sbjct: 282 DALEHEWLKTTDAATDSIDVPSLESTILN 310 >5KZ7-A nrPDB Length = 346 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 71/355 (20%), Positives = 145/355 (40%), Gaps = 61/355 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHE 69 +++L +G+G + V A H TG+ VA+K I+ + RE++I+K H Sbjct: 33 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 92 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ +F + E +Y++ E +++ + + + Q + AV+ Sbjct: 93 NIVKLFEVI-----ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 147 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H ++HRDLK NLL++++ ++K+ DFG + + + + + Sbjct: 148 CHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFG-----------NKLDTFCGSPP 196 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APE+ +DVWS G IL L F G++ + Sbjct: 197 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKEL---------------- 240 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 R +P Y ++ +LL++ L+ +P+KR T ++ ++ Sbjct: 241 -----RERVLRGKYRIPFY-----------MSTDCENLLKKFLILNPSKRGTLEQIMKDR 284 Query: 308 YLQTYHDPND-EPEGEPIPPSFFEFDHYKEALTTKDLKKLI--------WNEIFS 353 ++ H+ ++ +P EP+P + ++ ++ I +NE+ + Sbjct: 285 WMNVGHEDDELKPYVEPLPDYKDPR-RTELMVSMGYTREEIQDSLVGQRYNEVMA 338 >3ZDU-A nrPDB Length = 325 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 88/299 (29%), Positives = 145/299 (48%), Gaps = 18/299 (6%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 ++ +GEG+YG V HK TG+IVAIK + +REIK LK F HEN++ Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLV 64 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST--QMLSDDHIQYFIYQTLRAVKVLHG 130 + + F +++++ E + + + L ++ +++Q LRA+ LH Sbjct: 65 NLIEV-----FRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHS 119 Query: 131 SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRA 190 +N+IHRD+KP N+L++ + K+CDFG AR + + VATRWYRA Sbjct: 120 NNIIHRDIKPENILVSQSGITKLCDFGFARTL----------AAPGDIYDDEVATRWYRA 169 Query: 191 PEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRC 250 PE++L Y + +D+W+ GC++ E+ P P L I +G Sbjct: 170 PELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIF 229 Query: 251 IESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 +SP + +P +K +P++N D++ L DPA RI++ + L H Y Sbjct: 230 SKSPIFAGVVLPQVQHPKNARKK-YPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 287 >4RGJ-A nrPDB Length = 520 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 83/308 (26%), Positives = 139/308 (45%), Gaps = 54/308 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLREIKILKHFKH 68 ++ +LG+G++G V + K TG AIK I + LRE+++LK H Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDH 119 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 NI+ ++ FE+ N Y++ ++ +IS + + I Q L + Sbjct: 120 INIMKLYEF-----FEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGIT 174 Query: 127 VLHGSNVIHRDLKPSNLLI----NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 +H +NV+HRDLKP N+L+ + +K+ DFGL+ + S M + Sbjct: 175 YMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYS-----------KKMKDK 223 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 + T +Y AP+V+ Y D+WSCG IL L P F G + L + Sbjct: 224 IGTAYYIAPDVL--HGTYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV------- 274 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 A +Y LP F +++ K DL+++ML++ A RI+A++ Sbjct: 275 ------------EAGKYTFDLPQ---------FKKISDKAKDLIKKMLMYTSAVRISARD 313 Query: 303 ALEHPYLQ 310 ALEH +++ Sbjct: 314 ALEHEWIK 321 >2QNJ-A nrPDB Length = 328 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 77/354 (21%), Positives = 142/354 (40%), Gaps = 59/354 (16%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHE 69 +++L +G+G + V A H TG VAIK I+ P + RE++I+K H Sbjct: 12 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 71 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ +F + E +Y+I E +++ + + + Q + AV+ Sbjct: 72 NIVKLFEVI-----ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQY 126 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H ++HRDLK NLL++++ ++K+ DFG + + + + Sbjct: 127 CHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGG-----------KLDTFCGSPP 175 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APE+ +DVWS G IL L F G++ + Sbjct: 176 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKEL---------------- 219 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 R +P Y ++ +LL+R LV +P KR T ++ ++ Sbjct: 220 -----RERVLRGKYRIPFY-----------MSTDCENLLKRFLVLNPIKRGTLEQIMKDR 263 Query: 308 YLQTYHDPND-----EPEGEPIPPSFFEFDH---YKEALTTKDLKKLIWNEIFS 353 ++ H+ ++ EPE + + Y + + L K+ ++EI + Sbjct: 264 WINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITA 317 >3MN3-A nrPDB Length = 271 Score = 256 bits (655), Expect = 8e-69, Method: Composition-based stats. Identities = 81/318 (25%), Positives = 140/318 (44%), Gaps = 56/318 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLREIKILKHFKH 68 ++Q+ LGEG++G V A H TG+ VA+K I K R REI L+ +H Sbjct: 4 GNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRH 63 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQTLRAVKV 127 +II ++++ + + +E+ ++ E +L I +S+ + F Q + AV+ Sbjct: 64 PHIIKLYDVIK-----SKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEY 118 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H ++HRDLKP NLL++ + ++K+ DFGL+ I+ + + + Sbjct: 119 CHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTS-----------CGSPN 167 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APEV+ +DVWSCG IL + RR F D++ Sbjct: 168 YAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPF---------------------DDE 206 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 + + +LP + ++P L++RML+ +P RI+ E ++ Sbjct: 207 SIPVLFKNISNGVYTLPKF-----------LSPGAAGLIKRMLIVNPLNRISIHEIMQDD 255 Query: 308 YLQTYHDPNDEPEGEPIP 325 + + D PE P Sbjct: 256 WFKV-----DLPEYLLPP 268 >3SOA-A nrPDB Length = 444 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 89/320 (27%), Positives = 135/320 (42%), Gaps = 58/320 (18%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAI-----KKIEPFDKPLFALR 55 M + ++QL LG+GA+ VV G+ A KK+ D + Sbjct: 1 MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQ----K 56 Query: 56 TLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDH 113 RE +I + KH NI+ + DS Y+I +L+ +++ + S+ Sbjct: 57 LEREARICRLLKHPNIVRLH-----DSISEEGHHYLIFDLVTGGELFEDIVAREYYSEAD 111 Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNS 170 + I Q L AV H V+HR+LKP NLL+ S +K+ DFGLA Sbjct: 112 ASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLA----------I 161 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 E G+Q + T Y +PEV+ Y + +D+W+CG IL L + P F D Sbjct: 162 EVEGEQQAWFGFAGTPGYLSPEVLRKD-PYGKPVDLWACGVILYILLVGYPPFWDED--- 217 Query: 231 QLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRML 290 R + +A Y P + V P+ DL+ +ML Sbjct: 218 ----------------QHRLYQQIKAGAYDFPSPEWDT---------VTPEAKDLINKML 252 Query: 291 VFDPAKRITAKEALEHPYLQ 310 +P+KRITA EAL+HP++ Sbjct: 253 TINPSKRITAAEALKHPWIS 272 >5IG1-A nrPDB Length = 344 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 78/305 (25%), Positives = 137/305 (44%), Gaps = 51/305 (16%) Query: 17 SLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHENIITIF 75 S++G+GA+ V +K TGE+ A+K I + + REI I +HE+I+++ Sbjct: 23 SVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSM- 81 Query: 76 NIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNV 133 +F + + Y++ E + +++ + ++ ++Q L A++ H N+ Sbjct: 82 ----RRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNI 137 Query: 134 IHRDLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRA 190 IHRDLKP NLL+ + N +K+ DFGLA I+++ + T Y + Sbjct: 138 IHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYF-----------GFAGTPGYLS 186 Query: 191 PEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRC 250 PEV+ Y A+DVW+CG IL L + P F D++ I Sbjct: 187 PEVI-RRVPYDTAVDVWACGVILYILLVGYPPFWEEDHQKLYAQI--------------- 230 Query: 251 IESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 + +Y P + + V +L++ ML +P +R T +E L+HP++ Sbjct: 231 ----KNCQYDFPSPEWDS---------VTTAAKELIKAMLEPNPKRRPTVQELLQHPWIA 277 Query: 311 TYHDP 315 P Sbjct: 278 RRDVP 282 >3Q5I-A nrPDB Length = 504 Score = 253 bits (646), Expect = 9e-68, Method: Composition-based stats. Identities = 78/344 (22%), Positives = 138/344 (40%), Gaps = 63/344 (18%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD------------KPLFALRT 56 I + LG GAYG V K AIK I+ F Sbjct: 34 IGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEI 93 Query: 57 LREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHI 114 EI +LK H NII +F++ FE+ Y++ E + ++I+ + Sbjct: 94 YNEISLLKSLDHPNIIKLFDV-----FEDKKYFYLVTEFYEGGELFEQIINRHKFDECDA 148 Query: 115 QYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNC---DLKVCDFGLARIIDESAADNSE 171 + Q L + LH N++HRD+KP N+L+ + ++K+ DFGL+ Sbjct: 149 ANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFF--------- 199 Query: 172 PTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQ 231 + + + + T +Y APEV+ KY+ DVWSCG I+ L P F G++ + Sbjct: 200 --SKDYKLRDRLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQD- 254 Query: 232 LLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLV 291 I+ +Y + ++ + +L++ ML Sbjct: 255 ------------------IIKKVEKGKYYFDF---------NDWKNISDEAKELIKLMLT 287 Query: 292 FDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYK 335 +D KR TA+EAL +++ Y + ++ + + + + ++ Sbjct: 288 YDYNKRCTAEEALNSRWIKKYANNINKSDQKTLCGALSNMRKFE 331 >4CZT-A nrPDB Length = 464 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 84/326 (25%), Positives = 128/326 (39%), Gaps = 52/326 (15%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 ++L LGEG + V A + G+ VAIK I+ K + REI +K KH Sbjct: 11 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 70 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 N+I +F + + ++Y + E + ++ S L +D + + Q + AV Sbjct: 71 PNVIRMFEV-----MASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVD 125 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H V HRDLKP NLL+++N LKV DFGL+ + + D + T Sbjct: 126 YCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG--------LLHTTCGTP 177 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APEV+ D+WSCG IL L F + IF T Sbjct: 178 NYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP--- 234 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 P + L++R+L +PA RIT E +E+ Sbjct: 235 -----------------------------PWFSASAKKLIKRILDPNPATRITFAEVIEN 265 Query: 307 PYLQTYHDPNDEPEGEPIPPSFFEFD 332 + + + P+ E S + D Sbjct: 266 EWFKKGYK---APKFENADVSLDDVD 288 >3E3P-A nrPDB Length = 360 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 100/332 (30%), Positives = 160/332 (48%), Gaps = 24/332 (7%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 FQ++ + G+G +G V K TG VAIKK+ P F R L+ ++ L H N Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV--IQDPRFRNRELQIMQDLAVLHHPN 80 Query: 71 IITIFNIQRPDSFENFNEVYI--IQELMQTDLHR----VISTQMLSDD-HIQYFIYQTLR 123 I+ + + + ++Y+ + E + LHR Q+ I+ F++Q +R Sbjct: 81 IVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIR 140 Query: 124 AVKVLH--GSNVIHRDLKPSNLLINS-NCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 ++ LH NV HRD+KP N+L+N + LK+CDFG A+ + S + Sbjct: 141 SIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPN-----------V 189 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 Y+ +R+YRAPE++ + Y+ A+D+WS GCI AE+ L PIF G + QL I ++G Sbjct: 190 AYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLG 249 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 P + + S + S + + + + DLL +L + P +R+ Sbjct: 250 CPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKP 309 Query: 301 KEALEHPYLQTYHDPNDE-PEGEPIPPSFFEF 331 EAL HPY HDP + P + +P F F Sbjct: 310 YEALCHPYFDELHDPATKLPNNKDLPEDLFRF 341 >3H4J-B nrPDB Length = 336 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 82/316 (25%), Positives = 141/316 (44%), Gaps = 55/316 (17%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLREIKILKHFKHEN 70 + ++ LGEG++G V ATH T + VA+K I K +R REI LK +H + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQTLRAVKVLH 129 II ++++ + ++ ++ E +L I + +++D + F Q + A++ H Sbjct: 71 IIKLYDVITTPT-----DIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCH 125 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 ++HRDLKP NLL++ N ++K+ DFGL+ I+ + + + Y Sbjct: 126 RHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTS-----------CGSPNYA 174 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLR 249 APEV+ +DVWSCG +L + + R F Sbjct: 175 APEVINGKLYAGPEVDVWSCGIVLYVMLVGRLPFDD------------------------ 210 Query: 250 CIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 E+I +L + + M ++P L++RM+V DP +RIT +E P+ Sbjct: 211 --------EFIPNLFKKVNSCVYVMPDFLSPGAQSLIRRMIVADPMQRITIQEIRRDPWF 262 Query: 310 Q----TYHDPNDEPEG 321 Y P +E +G Sbjct: 263 NVNLPDYLRPMEEVQG 278 >2YCR-A nrPDB Length = 323 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 97/317 (30%), Positives = 150/317 (47%), Gaps = 58/317 (18%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-------KPLFALRTLREIK 61 + ++ + LG GA G V A + T + VAIK I + AL EI+ Sbjct: 8 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 67 Query: 62 ILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIY 119 ILK H II I N F + + YI+ ELM+ +V+ + L + + + Y Sbjct: 68 ILKKLNHPCIIKIKN------FFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFY 121 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLIN---SNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 Q L AV+ LH + +IHRDLKP N+L++ +C +K+ DFG ++I+ G+ Sbjct: 122 QMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL-----------GET 170 Query: 177 SGMTEYVATRWYRAPEVM--LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLL 234 S M T Y APEV+ + +A Y+RA+D WS G IL P F ++R Q+ L Sbjct: 171 SLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF--SEHRTQVSL 228 Query: 235 IFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDP 294 I ++ + +++ V+ K +DL++++LV DP Sbjct: 229 KDQITSGKYNF-------------------------IPEVWAEVSEKALDLVKKLLVVDP 263 Query: 295 AKRITAKEALEHPYLQT 311 R T +EAL HP+LQ Sbjct: 264 KARFTTEEALRHPWLQD 280 >2JAM-A nrPDB Length = 304 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 82/307 (26%), Positives = 132/307 (42%), Gaps = 52/307 (16%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 NI F +LG GA+ V + TG++ A+K I+ + EI +LK K Sbjct: 6 NIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSS-LENEIAVLKKIK 64 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 HENI+T+ +I +E+ Y++ +L+ R++ + ++ I Q L AV Sbjct: 65 HENIVTLEDI-----YESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAV 119 Query: 126 KVLHGSNVIHRDLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 K LH + ++HRDLKP NLL N + + DFGL+++ Q M+ Sbjct: 120 KYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM------------EQNGIMSTA 167 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 T Y APEV+ YS+A+D WS G I L P F Sbjct: 168 CGTPGYVAPEVL-AQKPYSKAVDCWSIGVITYILLCGYPPF------------------- 207 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 + + + + E + Y P + ++ D + +L DP +R T ++ Sbjct: 208 YEETESKLFEKIKEGYYEFESP---------FWDDISESAKDFICHLLEKDPNERYTCEK 258 Query: 303 ALEHPYL 309 AL HP++ Sbjct: 259 ALSHPWI 265 >4REW-A nrPDB Length = 540 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 80/345 (23%), Positives = 133/345 (38%), Gaps = 55/345 (15%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHFKHEN 70 + L LG G +G V H+ TG VA+K + + REI+ LK F+H + Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 67 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 II ++ + S +++++ E + + L + + Q L V Sbjct: 68 IIKLYQVISTPS-----DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYC 122 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H V+HRDLKP N+L++++ + K+ DFGL+ ++ + + + Y Sbjct: 123 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-----------CGSPNY 171 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 APEV+ +D+WS G IL L F D+D Sbjct: 172 AAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF---------------------DDDH 210 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 + + I P Y +NP I LL+ ML DP KR + K+ EH + Sbjct: 211 VPTLFKKICDGIFYTPQY-----------LNPSVISLLKHMLQVDPMKRASIKDIREHEW 259 Query: 309 LQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 + PE + + + KE + + E+ S Sbjct: 260 FKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSE---EEVLS 301 >5Y86-A nrPDB Length = 588 Score = 250 bits (639), Expect = 5e-67, Method: Composition-based stats. Identities = 93/346 (26%), Positives = 161/346 (46%), Gaps = 67/346 (19%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 +++ +++ ++G+G++G V + VA+K + ++ F + EI+IL+H K Sbjct: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR--NEKRFHRQAAEEIRILEHLK 261 Query: 68 HE------NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST---QMLSDDHIQYFI 118 + N+I + +SF N V + EL+ DL+ +I Q S ++ F Sbjct: 262 KQDKTGSMNVIHML-----ESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFA 316 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSNCD--LKVCDFGLARIIDESAADNSEPTGQQ 176 L+++ LH + +IH DLKP N+L+ + KV DFG + + Sbjct: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS-------------CFEY 363 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 + Y+ +R+YRAPE++L S +YS +D+WS GCILAEL +P+FPG D QL + Sbjct: 364 QKLYTYIQSRFYRAPEIILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMM 422 Query: 237 GIIGTPHSDNDLRCIESPRAREYI---KSLPMYPAAPLE-------------KMFPRVNP 280 ++G P + +E + +Y K +P Y + + + R P Sbjct: 423 ELLGMPP----PKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPP 478 Query: 281 KGID---------------LLQRMLVFDPAKRITAKEALEHPYLQT 311 D L+R L +DP+ R+T +AL HP++ Sbjct: 479 GSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 >5XZW-A nrPDB Length = 471 Score = 250 bits (639), Expect = 5e-67, Method: Composition-based stats. Identities = 80/319 (25%), Positives = 131/319 (41%), Gaps = 61/319 (19%) Query: 8 NISSDFQLK-SLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 I DF + ++G+GA+ V A + TG+ A+K I RE+++L+ Sbjct: 192 GIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKL 251 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-LSDDHIQYFIYQTLRA 124 H I+ + +E+ Y++ E + DL ++ + +D + Q L A Sbjct: 252 NHPRIVRLKGF-----YEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTA 306 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCD--LKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 +K +H + HRDLKP N+LI + +K+ DFGLA++ G S M + Sbjct: 307 IKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKV-----------QGNGSFMKTF 355 Query: 183 VATRWYRAPEVMLTS------------AKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 T Y APEV+ +YS +D+WS GC++ + F G + Sbjct: 356 CGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGST-QD 414 Query: 231 QLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRML 290 QL G Y PL+ R++ + D + +L Sbjct: 415 QLYKQIG-------------------------RGSYHEGPLKDF--RISEEARDFIDSLL 447 Query: 291 VFDPAKRITAKEALEHPYL 309 DP R TA +AL HP++ Sbjct: 448 QVDPNNRSTAAKALNHPWI 466 >5WAX-A nrPDB Length = 310 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 80/305 (26%), Positives = 125/305 (40%), Gaps = 50/305 (16%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 ++L +G G +GV ++ G++VA+K IE +K REI + +H Sbjct: 10 GDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEK--IDENVQREIINHRSLRHP 67 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NII + + + I+ E R+ + S+D ++F Q + V Sbjct: 68 NIIRFKEVILTPT-----HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 122 Query: 128 LHGSNVIHRDLKPSNLLINSNC--DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 H V HRDLK N L++ + LK+CDFG ++ S+ +S+P V T Sbjct: 123 CHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSK----SSVLHSQPKST-------VGT 171 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLL-IFGIIGTPHS 244 Y APEV+L + DVWSCG L + + F D I I+G +S Sbjct: 172 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYS 231 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 D + ++P+ DL+ R+ V +PA RIT E Sbjct: 232 IPD---------------------------YVHISPECQDLISRIFVANPATRITIPEIR 264 Query: 305 EHPYL 309 HP+ Sbjct: 265 NHPWF 269 >6C9D-A nrPDB Length = 459 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 68/354 (19%), Positives = 134/354 (37%), Gaps = 59/354 (16%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHE 69 +++L+ +G+G + V A H TG VA+K I+ P + RE++I+K H Sbjct: 21 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 80 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ +F + E +Y++ E +++ + + + Q + AV+ Sbjct: 81 NIVKLFEVI-----ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 135 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H ++HRDLK NLL++ + ++K+ DFG + + + E+ + Sbjct: 136 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVG-----------NKLDEFCGSPP 184 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APE+ +DVWS G IL L F G++ + Sbjct: 185 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKEL---------------- 228 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 R +P Y + E + ++ P KR + ++ ++ Sbjct: 229 -----RERVLRGKYRIPFYMSTDCENLLKKLLVLN-----------PIKRGSLEQIMKDR 272 Query: 308 YLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLI--------WNEIFS 353 ++ H+ + P F + +T + I ++E+ + Sbjct: 273 WMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMA 326 >5YKS-A nrPDB Length = 377 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 82/340 (24%), Positives = 137/340 (40%), Gaps = 54/340 (15%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFAL-RTLREIKILKHFK 67 I+ + L LG G + VV A H TGE VA+K I+ A +E++ +K + Sbjct: 33 IAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQ 92 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVI--STQMLSDDHIQYFIYQTLRA 124 H NI+ ++ + + ++Y+I EL D+ I + L++D + + Q + A Sbjct: 93 HPNIVRLYEVI-----DTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHA 147 Query: 125 VKVLHGSNVIHRDLKPSNL-LINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 + H +V+HRDLKP N+ +K+ DFG + +T Sbjct: 148 ISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPG-----------KKLTTSC 196 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 + Y APE++L + A+D+WS G IL L +P F + L +I T Sbjct: 197 GSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVP 256 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 S V+ + DL+ RML DP +R + +E Sbjct: 257 S--------------------------------HVSKECKDLITRMLQRDPKRRASLEEI 284 Query: 304 LEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDL 343 HP+LQ DP+ + S+ + + + Sbjct: 285 ENHPWLQGV-DPSPATKYNIPLVSYKNLSEEEHNSIIQRM 323 >2HAK-A nrPDB Length = 328 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 67/354 (18%), Positives = 133/354 (37%), Gaps = 59/354 (16%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHE 69 +++L+ +G+G + V A H TG VA+K I+ P + RE++I+K H Sbjct: 15 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 74 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ +F + E +Y++ E +++ + + + Q + AV+ Sbjct: 75 NIVKLFEVI-----ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQY 129 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 H ++HRDLK NLL++ + ++K+ DFG + + + + + Sbjct: 130 CHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVG-----------NKLDTFCGSPP 178 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APE+ +DVWS G IL L F G++ + Sbjct: 179 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKEL---------------- 222 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 R +P Y + E + ++ P KR + ++ ++ Sbjct: 223 -----RERVLRGKYRIPFYMSTDCENLLKKLLVLN-----------PIKRGSLEQIMKDR 266 Query: 308 YLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLI--------WNEIFS 353 ++ H+ + P F + +T + I ++E+ + Sbjct: 267 WMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMA 320 >3I6U-A nrPDB Length = 419 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 96/317 (30%), Positives = 150/317 (47%), Gaps = 58/317 (18%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-------KPLFALRTLREIK 61 + ++ + LG GA G V A + T + VAI+ I + AL EI+ Sbjct: 133 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIE 192 Query: 62 ILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIY 119 ILK H II I N F + + YI+ ELM+ +V+ + L + + + Y Sbjct: 193 ILKKLNHPCIIKIKN------FFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFY 246 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLIN---SNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 Q L AV+ LH + +IHRDLKP N+L++ +C +K+ DFG ++I+ G+ Sbjct: 247 QMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL-----------GET 295 Query: 177 SGMTEYVATRWYRAPEVM--LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLL 234 S M T Y APEV+ + +A Y+RA+D WS G IL P F ++R Q+ L Sbjct: 296 SLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF--SEHRTQVSL 353 Query: 235 IFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDP 294 I ++ + +++ V+ K +DL++++LV DP Sbjct: 354 KDQITSGKYNF-------------------------IPEVWAEVSEKALDLVKKLLVVDP 388 Query: 295 AKRITAKEALEHPYLQT 311 R T +EAL HP+LQ Sbjct: 389 KARFTTEEALRHPWLQD 405 >6FD3-A nrPDB Length = 300 Score = 247 bits (631), Expect = 6e-66, Method: Composition-based stats. Identities = 82/306 (26%), Positives = 136/306 (44%), Gaps = 47/306 (15%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 V + + +G+GA G V +A TG+ VAIK++ +P L + EI +++ Sbjct: 17 VGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL-IINEILVMRE 75 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDHIQYFIYQTLRA 124 K+ NI+ DS+ +E++++ E + L V++ + + I + L+A Sbjct: 76 NKNPNIVNYL-----DSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQA 130 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + LH + VIHRD+K N+L+ + +K+ DFG I T +QS + V Sbjct: 131 LDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI----------TPEQSKRSTMVG 180 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 T ++ APEV+ T Y +D+WS G + E+ P + + L LI GTP Sbjct: 181 TPYWMAPEVV-TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN-GTPEL 238 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 N R ++ D L R L D +R +AKE L Sbjct: 239 QNPER----------------------------LSAVFRDFLNRCLEMDVDRRGSAKELL 270 Query: 305 EHPYLQ 310 +HP+L+ Sbjct: 271 QHPFLK 276 >4CQG-A nrPDB Length = 331 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 83/315 (26%), Positives = 129/315 (40%), Gaps = 49/315 (15%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 ++L +G G + V A H TGE+VAIK ++ R EI LK +H++I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHIC 70 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLHG 130 ++++ E N+++++ E +IS LS++ + Q L AV +H Sbjct: 71 QLYHV-----LETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHS 125 Query: 131 SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRA 190 HRDLKP NLL + N LK+ DFGL + + E + Y A Sbjct: 126 QGYAHRDLKPENLLFDENHKLKLIDFGLCAK---------PKGNKDYHLQECCGSLAYAA 176 Query: 191 PEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRC 250 PE++ + DVWS G +L L F D+D Sbjct: 177 PELIQGKSYLGSEADVWSMGILLYVLMCGFLPF---------------------DDDNVM 215 Query: 251 IESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY-L 309 + +P + ++P I LLQ+ML DP KRI+ + L HP+ + Sbjct: 216 ALYKKIMRGKYEVPKW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVM 264 Query: 310 QTYHDPNDEPEGEPI 324 Q Y P + P+ Sbjct: 265 QDYSCPVEWQSKTPL 279 >4CFF-A nrPDB Length = 571 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 77/345 (22%), Positives = 133/345 (38%), Gaps = 55/345 (15%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHFKHEN 70 + L LG G +G V H+ TG VA+K + + REI+ LK F+H + Sbjct: 35 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 94 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 II ++ + + + +++ E + + + + + Q L AV Sbjct: 95 IIKLYQVISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 149 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H V+HRDLKP N+L++++ + K+ DFGL+ ++ + + + Y Sbjct: 150 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-----------CGSPNY 198 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 APEV+ +D+WSCG IL L F D++ Sbjct: 199 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF---------------------DDEH 237 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 + R + +P Y +N LL ML DP KR T K+ EH + Sbjct: 238 VPTLFKKIRGGVFYIPEY-----------LNRSVATLLMHMLQVDPLKRATIKDIREHEW 286 Query: 309 LQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 + PE + + + KE + + +E+ + Sbjct: 287 FKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTE---SEVMN 328 >3DAK-A nrPDB Length = 290 Score = 246 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 74/311 (23%), Positives = 127/311 (40%), Gaps = 42/311 (13%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 D++L+ ++G GA VV +A P E VAIK+I L+EI+ + H N Sbjct: 10 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPN 69 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQT----DLHRVI------STQMLSDDHIQYFIYQ 120 I++ + SF +E++++ +L+ D+ + I + +L + I + + Sbjct: 70 IVSYY-----TSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 124 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 L ++ LH + IHRD+K N+L+ + +++ DFG++ + + Sbjct: 125 VLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGD-----ITRNKVRK 179 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 +V T + APEVM Y D+WS G EL + Y +L+ + Sbjct: 180 TFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPY--HKYPPMKVLMLTLQN 237 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 P S + ++Y KS + L DP KR TA Sbjct: 238 DPPSLET-GVQDKEMLKKYGKSFRKM-------------------ISLCLQKDPEKRPTA 277 Query: 301 KEALEHPYLQT 311 E L H + Q Sbjct: 278 AELLRHKFFQK 288 >3COM-A nrPDB Length = 314 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 77/322 (23%), Positives = 138/322 (42%), Gaps = 60/322 (18%) Query: 2 PKRIVYNISSD---------FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLF 52 P+R + + D F + LGEG+YG V A HK TG+IVAIK++ Sbjct: 11 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV---ESD 67 Query: 53 ALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHR---VISTQML 109 ++EI I++ +++ + S+ +++I+ E + + L Sbjct: 68 LQEIIKEISIMQQCDSPHVVKYYG-----SYFKNTDLWIVMEYCGAGSVSDIIRLRNKTL 122 Query: 110 SDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADN 169 ++D I + TL+ ++ LH IHRD+K N+L+N+ K+ DFG+A + ++ A Sbjct: 123 TEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR 182 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 + + T ++ APEV+ Y+ D+WS G E+ +P + Sbjct: 183 N----------TVIGTPFWMAPEVIQE-IGYNCVADIWSLGITAIEMAEGKPPYA---DI 228 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 H + IF I P P + L + D +++ Sbjct: 229 HPMRAIFMIPTNPP--------------------PTFRKPEL------WSDNFTDFVKQC 262 Query: 290 LVFDPAKRITAKEALEHPYLQT 311 LV P +R TA + L+HP++++ Sbjct: 263 LVKSPEQRATATQLLQHPFVRS 284 >4NIF-A nrPDB Length = 333 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 76/310 (24%), Positives = 135/310 (43%), Gaps = 53/310 (17%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKIL-KHFK 67 S + +K +G G+Y HK T A+K I+ + EI+IL ++ + Sbjct: 6 FSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-----EIEILLRYGQ 60 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H NIIT+ ++ +++ VY++ ELM+ L +++ + S+ + ++ + V Sbjct: 61 HPNIITLKDV-----YDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTV 115 Query: 126 KVLHGSNVIHRDLKPSNLL-INSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 + LH V+HRDLKPSN+L ++ + + L++CDFG A+ + P Sbjct: 116 EYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCY------- 168 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 T + APEV+ Y D+WS G +L + F Sbjct: 169 ---TANFVAPEVL-KRQGYDEGCDIWSLGILLYTMLAGYTPF----------------AN 208 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 SD + + ++ S + V+ DL+ +ML DP +R+TAK Sbjct: 209 GPSDTPEEILTRIGSGKFTLSGG---------NWNTVSETAKDLVSKMLHVDPHQRLTAK 259 Query: 302 EALEHPYLQT 311 + L+HP++ Sbjct: 260 QVLQHPWVTQ 269 >4D2V-A nrPDB Length = 356 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 81/314 (25%), Positives = 128/314 (40%), Gaps = 49/314 (15%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 ++L +G G + V A H TGE+VAIK ++ R EI+ LK+ +H++I Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHIC 90 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLHG 130 ++++ E N+++++ E +IS LS++ + Q + AV +H Sbjct: 91 QLYHV-----LETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHS 145 Query: 131 SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRA 190 HRDLKP NLL + LK+ DFGL + + Y A Sbjct: 146 QGYAHRDLKPENLLFDEYHKLKLIDFGLCAK---------PKGNKDYHLQACCGALAYAA 196 Query: 191 PEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRC 250 PE++ + DVWS G +L L F D+D Sbjct: 197 PELIQGKSYLGSEADVWSMGILLYVLMCGFLPF---------------------DDDTAA 235 Query: 251 IESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL- 309 + +P + ++P I LLQ+ML DP KRI+ K L HP++ Sbjct: 236 ALVAKIMRGKYDVPKW-----------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIM 284 Query: 310 QTYHDPNDEPEGEP 323 Q Y+ P + P Sbjct: 285 QDYNYPVEWQSKNP 298 >4CFH-A nrPDB Length = 493 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 81/345 (23%), Positives = 133/345 (38%), Gaps = 55/345 (15%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHFKHEN 70 + L LG G +G V H+ TG VA+K + + REI+ LK F+H + Sbjct: 35 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 94 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 II ++ + S +++++ E + + L + + Q L V Sbjct: 95 IIKLYQVISTPS-----DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYC 149 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H V+HRDLKP N+L++++ + K+ DFGL+ ++ + + + Y Sbjct: 150 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-----------CGSPNY 198 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 APEV+ +D+WS G IL L F D+D Sbjct: 199 AAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF---------------------DDDH 237 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 + + I P Y +NP I LL+ ML DP KR T K+ EH + Sbjct: 238 VPTLFKKICDGIFYTPQY-----------LNPSVISLLKHMLQVDPMKRATIKDIREHEW 286 Query: 309 LQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 + PE + + + KE + + E+ S Sbjct: 287 FKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSE---EEVLS 328 >5EZV-A nrPDB Length = 560 Score = 245 bits (625), Expect = 2e-65, Method: Composition-based stats. Identities = 77/345 (22%), Positives = 133/345 (38%), Gaps = 55/345 (15%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHFKHEN 70 + L LG G +G V H+ TG VA+K + + REI+ LK F+H + Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 89 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 II ++ + + + +++ E + + + + + Q L AV Sbjct: 90 IIKLYQVISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 144 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H V+HRDLKP N+L++++ + K+ DFGL+ ++ + + + Y Sbjct: 145 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-----------CGSPNY 193 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 APEV+ +D+WSCG IL L F D++ Sbjct: 194 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF---------------------DDEH 232 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 + R + +P Y +N LL ML DP KR T K+ EH + Sbjct: 233 VPTLFKKIRGGVFYIPEY-----------LNRSVATLLMHMLQVDPLKRATIKDIREHEW 281 Query: 309 LQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 + PE + + + KE + + +E+ + Sbjct: 282 FKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTE---SEVMN 323 >4D28-A nrPDB Length = 446 Score = 245 bits (625), Expect = 2e-65, Method: Composition-based stats. Identities = 78/318 (24%), Positives = 127/318 (39%), Gaps = 51/318 (16%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 +++ +GEG + V A + TG+ VAIK + K + REI I+K +H Sbjct: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 NI+ ++ + S ++YI+ E + R++ L +D + + Q + AV Sbjct: 69 PNIVRLYEVLASKS-----KIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVA 123 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H V HRDLKP NLL+++N +LKV DFGL+ + E + + T Sbjct: 124 HCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVEL----------LNDTCGTP 173 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APEV+ A D+WSCG IL + F D I Sbjct: 174 NYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI----------- 222 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 + + P + + L+ R+L +P RI + + Sbjct: 223 ---------------NAAEFDCPPW------FSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 Query: 307 PYLQTYHDPNDEPEGEPI 324 P+ + + P E E + Sbjct: 262 PWFRKNYVPIRAREEEEV 279 >4RED-A nrPDB Length = 351 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 80/345 (23%), Positives = 133/345 (38%), Gaps = 55/345 (15%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHFKHEN 70 + L LG G +G V H+ TG VA+K + + REI+ LK F+H + Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 75 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 II ++ + S +++++ E + + L + + Q L V Sbjct: 76 IIKLYQVISTPS-----DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYC 130 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H V+HRDLKP N+L++++ + K+ DFGL+ ++ + + + Y Sbjct: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-----------CGSPNY 179 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 APEV+ +D+WS G IL L F D+D Sbjct: 180 AAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF---------------------DDDH 218 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 + + I P Y +NP I LL+ ML DP KR + K+ EH + Sbjct: 219 VPTLFKKICDGIFYTPQY-----------LNPSVISLLKHMLQVDPMKRASIKDIREHEW 267 Query: 309 LQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 + PE + + + KE + + E+ S Sbjct: 268 FKQDLPKYLFPEDPSYSTTMIDDEALKEVCEKFECSE---EEVLS 309 >5JZN-A nrPDB Length = 280 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 73/314 (23%), Positives = 128/314 (40%), Gaps = 51/314 (16%) Query: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKIL 63 +I I+ +++ +G+G + VV + T A+K I+ E+ IL Sbjct: 12 QIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSIL 71 Query: 64 KHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQT 121 + KH NI+ + + + E+Y++ EL++ + ST ++ +Y Sbjct: 72 RRVKHPNIVLLI-----EEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNL 126 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLI----NSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 A+K LH N++HRD+KP NLL+ + + LK+ DFGLA I+D Sbjct: 127 ASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVD-------------G 173 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 + T Y APE++ + Y +D+W+ G I L P F G Sbjct: 174 PLYTVCGTPTYVAPEIIAETG-YGLKVDIWAAGVITYILLCGFPPFRGS----------- 221 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 D+ + + P + V+ +L+ ML+ D +R Sbjct: 222 ------GDDQEVLFDQILMGQVDFPSPYWD---------NVSDSAKELITMMLLVDVDQR 266 Query: 298 ITAKEALEHPYLQT 311 +A + LEHP++ Sbjct: 267 FSAVQVLEHPWVND 280 >3F3Z-A nrPDB Length = 277 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 85/309 (27%), Positives = 132/309 (42%), Gaps = 52/309 (16%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 +I+ + L++ +G G++G V A K T A KKI P R +EI+I+K Sbjct: 6 DINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKI-PKYFVEDVDRFKQEIEIMKSLD 64 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H NII ++ ++FE+ ++Y++ EL RV+ ++ + + L AV Sbjct: 65 HPNIIRLY-----ETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAV 119 Query: 126 KVLHGSNVIHRDLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 H NV HRDLKP N L + + LK+ DFGLA M Sbjct: 120 AYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPG-----------KMMRTK 168 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 V T +Y +P+V+ Y D WS G ++ L P F +L I Sbjct: 169 VGTPYYVSPQVL--EGLYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKI------- 219 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 RE + P EK + V+P+ L++R+L P +RIT+ + Sbjct: 220 --------------REGTFTFP-------EKDWLNVSPQAESLIRRLLTKSPKQRITSLQ 258 Query: 303 ALEHPYLQT 311 ALEH + + Sbjct: 259 ALEHEWFEK 267 >3TAC-A nrPDB Length = 361 Score = 244 bits (622), Expect = 6e-65, Method: Composition-based stats. Identities = 81/312 (25%), Positives = 136/312 (43%), Gaps = 58/312 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA----LRTLREIKILKHFKH 68 ++L ++G+G + VV ++ TG+ A+K ++ RE I KH Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQT-DL-----HRVISTQMLSDDHIQYFIYQTL 122 +I+ + +++ + +Y++ E M DL R + + S+ +++ Q L Sbjct: 88 PHIVELL-----ETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQIL 142 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 A++ H +N+IHRD+KP +L+ S + +K+ FG+A + ES Sbjct: 143 EALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAG--------- 193 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 V T + APEV+ Y + +DVW CG IL L F G R L GII Sbjct: 194 -GRVGTPHFMAPEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYGTKER----LFEGII 247 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 + N + + ++ DL++RML+ DPA+RIT Sbjct: 248 KGKYKMNP-------------------------RQWSHISESAKDLVRRMLMLDPAERIT 282 Query: 300 AKEALEHPYLQT 311 EAL HP+L+ Sbjct: 283 VYEALNHPWLKE 294 >2HW6-A nrPDB Length = 307 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 75/309 (24%), Positives = 127/309 (41%), Gaps = 32/309 (10%) Query: 17 SLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HENIITIF 75 LLGEGAY V A G+ A+K IE R RE++ L + ++NI+ + Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHS-RSRVFREVETLYQCQGNKNILELI 77 Query: 76 NIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNV 133 FE+ Y++ E +Q L + + ++ + A+ LH + Sbjct: 78 EF-----FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGI 132 Query: 134 IHRDLKPSNLLINSN---CDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRA 190 HRDLKP N+L S +K+CDF L + +NS +T + Y A Sbjct: 133 AHRDLKPENILCESPEKVSPVKICDFDLGSGMK---LNNSCTPITTPELTTPCGSAEYMA 189 Query: 191 PEVML----TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 PEV+ + Y + D+WS G +L + P F G G Sbjct: 190 PEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGH---------CGADCGWDRGE 240 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 R ++ + +P +K + ++ + DL+ ++LV D +R++A + L+H Sbjct: 241 VCRVCQNKLFESIQEGKYEFP----DKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQH 296 Query: 307 PYLQTYHDP 315 P++Q Sbjct: 297 PWVQGQAPE 305 >2W4O-A nrPDB Length = 349 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 82/306 (26%), Positives = 127/306 (41%), Gaps = 52/306 (16%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 +S F+++S LG GA +V K T + A+K ++ EI +L H Sbjct: 51 LSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI---VRTEIGVLLRLSH 107 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 NII + I FE E+ ++ EL+ R++ S+ + Q L AV Sbjct: 108 PNIIKLKEI-----FETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVA 162 Query: 127 VLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 LH + ++HRDLKP NLL + + LK+ DFGL++I++ Q M Sbjct: 163 YLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVE-----------HQVLMKTVC 211 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 T Y APE++ A Y +D+WS G I L F Sbjct: 212 GTPGYCAPEILRGCA-YGPEVDMWSVGIITYILLCGFEPFYDE----------------- 253 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 D EY P + V+ DL+++++V DP KR+T +A Sbjct: 254 -RGDQFMFRRILNCEYYFISPWWD---------EVSLNAKDLVRKLIVLDPKKRLTTFQA 303 Query: 304 LEHPYL 309 L+HP++ Sbjct: 304 LQHPWV 309 >4PDS-A nrPDB Length = 347 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 78/320 (24%), Positives = 131/320 (40%), Gaps = 61/320 (19%) Query: 8 NISSDFQLK-SLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 I DF + ++G+GA+ V A + TG+ ++K I RE+++L+ Sbjct: 27 GIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKL 86 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-LSDDHIQYFIYQTLRA 124 H I+ + +E+ Y++ E + DL ++ + +D + Q L A Sbjct: 87 NHPRIVRLKGF-----YEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTA 141 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCD--LKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 +K +H + HRDLKP N+LI + +K+ FGLA++ G S M + Sbjct: 142 IKYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKV-----------QGNGSFMKTF 190 Query: 183 VATRWYRAPEVMLTS------------AKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 T Y APEV+ +YS +D+WS GC++ + F G + Sbjct: 191 CGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGST-QD 249 Query: 231 QLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRML 290 QL G Y PL+ R++ + D + +L Sbjct: 250 QLYKQIG-------------------------RGSYHEGPLKDF--RISEEARDFIDSLL 282 Query: 291 VFDPAKRITAKEALEHPYLQ 310 DP R TA +AL HP+++ Sbjct: 283 QVDPNNRSTAAKALNHPWIK 302 >5ZTN-A nrPDB Length = 429 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 90/342 (26%), Positives = 158/342 (46%), Gaps = 61/342 (17%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 +++ +++ ++G+G++G V A + VA+K + ++ F + EI+IL+H + Sbjct: 94 HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVR--NEKRFHRQAAEEIRILEHLR 151 Query: 68 HE------NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST---QMLSDDHIQYFI 118 + N+I + ++F N + + EL+ +L+ +I Q S ++ F Sbjct: 152 KQDKDNTMNVIHML-----ENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFA 206 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSNCD--LKVCDFGLARIIDESAADNSEPTGQQ 176 + L+ + LH + +IH DLKP N+L+ +KV DFG + + Sbjct: 207 HSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS-------------CYEH 253 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 + Y+ +R+YRAPEV+L A+Y +D+WS GCILAEL P+ PG D QL + Sbjct: 254 QRVYTYIQSRFYRAPEVILG-ARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMI 312 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPMYP-----------------------AAPLEK 273 ++G P S L + + K P Y P + Sbjct: 313 ELLGMP-SQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESR 371 Query: 274 MFPRV-----NPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 + +P +D L++ L +DPA R+T +AL HP+L+ Sbjct: 372 EWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR 413 >3D2K-A nrPDB Length = 272 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 74/304 (24%), Positives = 122/304 (40%), Gaps = 54/304 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLREIKILKHFKH 68 DF + LG+G +G V A + + I+A+K + +K + RE++I H +H Sbjct: 12 EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRH 71 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQEL--MQTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 NI+ ++ F + VY+I E + T + + +I + A+ Sbjct: 72 PNILRLYGY-----FHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALS 126 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H VIHRD+KP NLL+ SN +LK+ DFG + S T T Sbjct: 127 YCHSKRVIHRDIKPENLLLGSNGELKIADFGWS------------VHAPSSRRTTLCGTL 174 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y PE M+ + +D+WS G + E + P F Y+ I + Sbjct: 175 DYLPPE-MIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRV-------- 225 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 + P + V DL+ R+L + ++R+T E LEH Sbjct: 226 -------------EFTFPDF-----------VTEGARDLISRLLKHNASQRLTLAEVLEH 261 Query: 307 PYLQ 310 P+++ Sbjct: 262 PWIK 265 >6O6Q-A nrPDB Length = 335 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 84/319 (26%), Positives = 152/319 (47%), Gaps = 30/319 (9%) Query: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKIL 63 I +N ++++ LG G Y V E V IK ++P + + REI IL Sbjct: 34 NIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRK----KIKREISIL 89 Query: 64 KHF-KHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQMLSDDHIQYFIYQT 121 K+ NII + ++ R + +I E + D + T +D I++++Y+ Sbjct: 90 KNLVDGPNIIAMLDVVREPQSKTPG---LIFEHINNIDFRSLYPT--FTDYDIRFYMYEL 144 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCD-LKVCDFGLARIIDESAADNSEPTGQQSGMT 180 L+A+ H ++HRD+KP N++I+ + L++ D+GLA N Sbjct: 145 LKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVR--------- 195 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL-FLRRPIFPGRDYRHQLLLIFGII 239 VA+R+++ PE+++ Y ++D+WS GC+LA + F++ P F G+ QL+ I ++ Sbjct: 196 --VASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVL 253 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR-----VNPKGIDLLQRMLVFDP 294 G+ + L EY + + Y + V+ + +DL+ R+L +D Sbjct: 254 GSKNFKKYLEKYNISLGEEY-EDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDH 312 Query: 295 AKRITAKEALEHPYLQTYH 313 +R+TAKEA++H Y Sbjct: 313 QERLTAKEAMKHAYFDPIR 331 >3ZUT-A nrPDB Length = 362 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 82/344 (23%), Positives = 135/344 (39%), Gaps = 51/344 (14%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 S ++L +G G +GV K + E+VA+K IE +K REI + +H Sbjct: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK--IDENVKREIINHRSLRHP 75 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ + + + I+ E R+ + S+D ++F Q + V Sbjct: 76 NIVRFKEVILTPT-----HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 Query: 128 LHGSNVIHRDLKPSNLLINSNC--DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 H V HRDLK N L++ + LK+C FG ++ S+ +S+P V T Sbjct: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSK----SSVLHSQPKST-------VGT 179 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Y APEV+L + DVWSCG L + + F + Sbjct: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIH-------- 231 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 R ++P Y ++P+ L+ R+ V DPAKRI+ E Sbjct: 232 ---------RILNVQYAIPDYV---------HISPECRHLISRIFVADPAKRISIPEIRN 273 Query: 306 HPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWN 349 H + + P D + F E D + + +++ ++I Sbjct: 274 HEWFLK-NLPADLMNDNTMTTQFDESDQPGQ--SIEEIMQIIAE 314 >2YAB-A nrPDB Length = 361 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 81/355 (22%), Positives = 132/355 (37%), Gaps = 60/355 (16%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA-----LR 55 M + + + LG G + +V K TG A K I+ Sbjct: 2 METFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREE 61 Query: 56 TLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDH 113 RE+ IL+ H NIIT+ ++ +EN +V +I EL+ + + LS++ Sbjct: 62 IEREVSILRQVLHPNIITLHDV-----YENRTDVVLILELVSGGELFDFLAQKESLSEEE 116 Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNC----DLKVCDFGLARIIDESAADN 169 FI Q L V LH + H DLKP N+++ +K+ DFGLA I++ Sbjct: 117 ATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-- 174 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 T + APE ++ D+WS G I L F G + Sbjct: 175 ---------FKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQ 224 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 L I + Y E+ F + + D ++++ Sbjct: 225 ETLANITAV-------------------SYDFD---------EEFFSQTSELAKDFIRKL 256 Query: 290 LVFDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLK 344 LV + KR+T +EAL HP++ P D + S +++K+ + K Sbjct: 257 LVKETRKRLTIQEALRHPWIT----PVDTQQAMVRRESVVNLENFKKQYVRRRWK 307 >4UZD-A nrPDB Length = 287 Score = 241 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 74/303 (24%), Positives = 122/303 (40%), Gaps = 54/303 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLREIKILKHFKH 68 DF++ LG+G +G V A K + I+A+K + +K + RE++I H +H Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQEL--MQTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 NI+ ++ F + VY+I E + T + + +I + A+ Sbjct: 68 PNILRLYGY-----FHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 122 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H VIHRD+KP NLL+ S +LK+ DFG + S T T Sbjct: 123 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWS------------VHAPSSRRTTLCGTL 170 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y PE M+ + +D+WS G + E + +P F Y+ I + Sbjct: 171 DYLPPE-MIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRV-------- 221 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 + P + V DL+ R+L +P++R +E LEH Sbjct: 222 -------------EFTFPDF-----------VTEGARDLISRLLKHNPSQRPMLREVLEH 257 Query: 307 PYL 309 P++ Sbjct: 258 PWI 260 >4FIE-A nrPDB Length = 423 Score = 241 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 74/300 (24%), Positives = 140/300 (46%), Gaps = 47/300 (15%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +GEG+ G+VC AT + +G++VA+KK++ + L E+ I++ ++HEN++ ++N Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL-LFNEVVIMRDYQHENVVEMYN- 215 Query: 78 QRPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 S+ +E++++ E ++ L +++ ++++ I L+A+ VLH VIHR Sbjct: 216 ----SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHR 271 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 D+K ++L+ + +K+ DFG + + V T ++ APE +++ Sbjct: 272 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSL----------VGTPYWMAPE-LIS 320 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 Y +D+WS G ++ E+ P + + +I + Sbjct: 321 RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL----------------- 363 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 P K +V+P L R+LV DPA+R TA E L+HP+L P Sbjct: 364 ------------PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 411 >4JG6-A nrPDB Length = 355 Score = 240 bits (613), Expect = 6e-64, Method: Composition-based stats. Identities = 74/309 (23%), Positives = 133/309 (43%), Gaps = 53/309 (17%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKIL-KHF 66 + +++K +G G+Y V HK T A+K I+ + EI+IL ++ Sbjct: 32 QFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-----EIEILLRYG 86 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRA 124 +H NIIT+ ++ +++ VY++ ELM+ L +++ + S+ ++ + Sbjct: 87 QHPNIITLKDV-----YDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKT 141 Query: 125 VKVLHGSNVIHRDLKPSNLL-INSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGMT 180 V+ LH V+HRDLKPSN+L ++ + + +++CDFG A+ + P Sbjct: 142 VEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY------ 195 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 T + APEV+ Y A D+WS G +L + F Sbjct: 196 ----TANFVAPEVL-ERQGYDAACDIWSLGVLLYTMLTGYTPF----------------A 234 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 D + + ++ S + V+ DL+ +ML DP +R+TA Sbjct: 235 NGPDDTPEEILARIGSGKFSLSGG---------YWNSVSDTAKDLVSKMLHVDPHQRLTA 285 Query: 301 KEALEHPYL 309 L HP++ Sbjct: 286 ALVLRHPWI 294 >3EB0-A nrPDB Length = 383 Score = 240 bits (613), Expect = 6e-64, Method: Composition-based stats. Identities = 101/344 (29%), Positives = 158/344 (45%), Gaps = 60/344 (17%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 S + L LG G++G+VC +G+ A+KK+ P + RE+ I+K H Sbjct: 6 SKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKV--LQDPRYKN---RELDIMKVLDHV 60 Query: 70 NIITIFNIQRPDSFENFNE---------------------------------VYIIQELM 96 NII + + E + +I E + Sbjct: 61 NIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYV 120 Query: 97 QTDLHRVIST-----QMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINS-NCD 150 LH+V+ + + + + I +IYQ RAV +H + HRD+KP NLL+NS + Sbjct: 121 PDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT 180 Query: 151 LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCG 210 LK+CDFG A+ + S Y+ +R+YRAPE+ML + +Y+ ++D+WS G Sbjct: 181 LKLCDFGSAKKLIPSEPS-----------VAYICSRFYRAPELMLGATEYTPSIDLWSIG 229 Query: 211 CILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAP 270 C+ EL L +P+F G QL+ I I+GTP + +R +P E P A Sbjct: 230 CVFGELILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRM--NPHYTEV--RFPTLKAKD 285 Query: 271 LEKMFPRVNPK-GIDLLQRMLVFDPAKRITAKEALEHPYLQTYH 313 K+ P P IDLL+++L ++P RI EA+ HP+ Sbjct: 286 WRKILPEGTPSLAIDLLEQILRYEPDLRINPYEAMAHPFFDHLR 329 >2J90-A nrPDB Length = 304 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 78/327 (23%), Positives = 127/327 (38%), Gaps = 56/327 (17%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-----KPLFALRTLRE 59 + +++ LG G + +V K TG+ A K I+ + + RE Sbjct: 20 FQSMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIERE 79 Query: 60 IKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYF 117 + IL+ +H NIIT+ +I FEN +V +I EL+ + + L++D F Sbjct: 80 VNILREIRHPNIITLHDI-----FENKTDVVLILELVSGGELFDFLAEKESLTEDEATQF 134 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLINS----NCDLKVCDFGLARIIDESAADNSEPT 173 + Q L V LH + H DLKP N+++ N +K+ DFG+A I+ Sbjct: 135 LKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNE------ 188 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLL 233 T + APE ++ D+WS G I L F G + L Sbjct: 189 -----FKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLT 242 Query: 234 LIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFD 293 I + Y E+ F + D ++R+LV D Sbjct: 243 NISAV-------------------NYDFD---------EEYFSNTSELAKDFIRRLLVKD 274 Query: 294 PAKRITAKEALEHPYLQTYHDPNDEPE 320 P +R+T ++LEH +++ N E Sbjct: 275 PKRRMTIAQSLEHSWIKAIRRRNVRGE 301 >3UC3-A nrPDB Length = 361 Score = 240 bits (612), Expect = 8e-64, Method: Composition-based stats. Identities = 80/308 (25%), Positives = 120/308 (38%), Gaps = 56/308 (18%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 S + +G G +GV K T E+VA+K IE REI + +H Sbjct: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE--RGAAIDENVQREIINHRSLRHP 76 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ + + + II E R+ + S+D ++F Q L V Sbjct: 77 NIVRFKEVILTPT-----HLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 Query: 128 LHGSNVIHRDLKPSNLLINSNC--DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 H + HRDLK N L++ + LK+CDFG ++ S+ +S+P V T Sbjct: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK----SSVLHSQPKST-------VGT 180 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG----RDYRHQLLLIFGIIGT 241 Y APEV+L + DVWSCG L + + F RDYR + I + + Sbjct: 181 PAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYS 240 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 D R++P+ L+ R+ V DPA RI+ Sbjct: 241 IPDDI------------------------------RISPECCHLISRIFVADPATRISIP 270 Query: 302 EALEHPYL 309 E H + Sbjct: 271 EIKTHSWF 278 >5DBX-A nrPDB Length = 328 Score = 240 bits (612), Expect = 8e-64, Method: Composition-based stats. Identities = 74/309 (23%), Positives = 127/309 (41%), Gaps = 42/309 (13%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 ++L+ ++G GA VV +A KP E VAIK+I L+EI+ + H N++ Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVV 72 Query: 73 TIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIS---------TQMLSDDHIQYFIYQTL 122 T + SF +E++++ +L+ + +I +L + I + + L Sbjct: 73 TYY-----TSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVL 127 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + LH + IHRDLK N+L+ + +++ DFG++ + + ++ Sbjct: 128 EGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGD-----VTRNKVRKDF 182 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 V T + APEVM Y D+WS G EL + Y +L+ + P Sbjct: 183 VGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPY--HKYPPMKVLMLTLQNDP 240 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 + + ++Y KS LL L DP+KR TA E Sbjct: 241 PTLET-GVEDKEMMKKYGKSFRK-------------------LLSLCLQKDPSKRPTAAE 280 Query: 303 ALEHPYLQT 311 L+ + Q Sbjct: 281 LLKCKFFQK 289 >3IS5-A nrPDB Length = 285 Score = 240 bits (612), Expect = 8e-64, Method: Composition-based stats. Identities = 78/316 (24%), Positives = 124/316 (39%), Gaps = 56/316 (17%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILK 64 I F K LG GA+G V + +G IK I + + EI++LK Sbjct: 16 FQGTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLK 75 Query: 65 HFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQ----MLSDDHIQYFI 118 H NII IF + FE+++ +YI+ E + L R++S Q LS+ ++ + Sbjct: 76 SLDHPNIIKIFEV-----FEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELM 130 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQ 175 Q + A+ H +V+H+DLKP N+L + +K+ DFGLA + Sbjct: 131 KQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDE--------- 181 Query: 176 QSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLI 235 T T Y APEV + D+WS G ++ L F G Sbjct: 182 --HSTNAAGTALYMAPEVF--KRDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEE----- 232 Query: 236 FGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPA 295 ++ Y + P+ +DLL++ML DP Sbjct: 233 ------------------------VQQKATYKEPNYAVECRPLTPQAVDLLKQMLTKDPE 268 Query: 296 KRITAKEALEHPYLQT 311 +R +A + L H + + Sbjct: 269 RRPSAAQVLHHEWFKQ 284 >5X8I-B nrPDB Length = 346 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 99/338 (29%), Positives = 148/338 (43%), Gaps = 54/338 (15%) Query: 9 ISSDFQLKSLLGEGAYGVVCSAT-HKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 +S+ +++ LGEGA+G V HK G VA+K ++ D+ A R EI++L+H Sbjct: 11 LSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAAR--SEIQVLEHLN 68 Query: 68 --HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQML---SDDHIQYFIYQTL 122 N T +Q + FE+ + I+ EL+ + I DHI+ YQ Sbjct: 69 TTDPN-STFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQIC 127 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINS-------------------NCDLKVCDFGLARIID 163 ++V LH + + H DLKP N+L N D+KV DFG A Sbjct: 128 KSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA---- 183 Query: 164 ESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 T + V+TR YRAPEV+L +S+ DVWS GCIL E +L +F Sbjct: 184 ---------TYDDEHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEYYLGFTVF 233 Query: 224 PGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMY------------PAAPL 271 P D + L ++ I+G + + + P Sbjct: 234 PTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEF 293 Query: 272 EKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 + + DL+Q+ML +DPAKRIT +EAL+HP+ Sbjct: 294 MLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >4JDH-A nrPDB Length = 346 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 74/300 (24%), Positives = 140/300 (46%), Gaps = 47/300 (15%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +GEG+ G+VC AT + +G++VA+KK++ + L E+ I++ ++HEN++ ++N Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL-LFNEVVIMRDYQHENVVEMYN- 138 Query: 78 QRPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 S+ +E++++ E ++ L +++ ++++ I L+A+ VLH VIHR Sbjct: 139 ----SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHR 194 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 D+K ++L+ + +K+ DFG + + V T ++ APE +++ Sbjct: 195 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSL----------VGTPYWMAPE-LIS 243 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 Y +D+WS G ++ E+ P + + +I + Sbjct: 244 RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL----------------- 286 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 P K +V+P L R+LV DPA+R TA E L+HP+L P Sbjct: 287 ------------PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 334 >2YZA-A nrPDB Length = 276 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 74/312 (23%), Positives = 123/312 (39%), Gaps = 52/312 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE--PFDKPLFALRTLREIKILKHFKHEN 70 + L LG G +G V H+ TG VA+K + + REI+ LK F+H + Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 72 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 II ++ + + + +++ E + + + + + Q L AV Sbjct: 73 IIKLYQVISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 127 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H V+HRDLKP N+L++++ + K+ DFGL+ ++ + + + + Y Sbjct: 128 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-----------LRDSCGSPNY 176 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 APEV+ +D+WSCG IL L F D++ Sbjct: 177 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF---------------------DDEH 215 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 + R + +P Y +N LL ML DP KR T K+ EH + Sbjct: 216 VPTLFKKIRGGVFYIPEY-----------LNRSVATLLMHMLQVDPLKRATIKDIREHEW 264 Query: 309 LQTYHDPNDEPE 320 + PE Sbjct: 265 FKQDLPSYLFPE 276 >4XBR-A nrPDB Length = 366 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 74/300 (24%), Positives = 140/300 (46%), Gaps = 47/300 (15%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +GEG+ G+VC AT + +G++VA+KK++ + L E+ I++ ++HEN++ ++N Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL-LFNEVVIMRDYQHENVVEMYN- 158 Query: 78 QRPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 S+ +E++++ E ++ L +++ ++++ I L+A+ VLH VIHR Sbjct: 159 ----SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHR 214 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 D+K ++L+ + +K+ DFG + + V T ++ APE +++ Sbjct: 215 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSL----------VGTPYWMAPE-LIS 263 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 Y +D+WS G ++ E+ P + + +I + Sbjct: 264 RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL----------------- 306 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 P K +V+P L R+LV DPA+R TA E L+HP+L P Sbjct: 307 ------------PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 354 >2Q0N-A nrPDB Length = 301 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 74/300 (24%), Positives = 140/300 (46%), Gaps = 47/300 (15%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +GEG+ G+VC AT + +G++VA+KK++ + L E+ I++ ++HEN++ ++N Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL-LFNEVVIMRDYQHENVVEMYN- 93 Query: 78 QRPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 S+ +E++++ E ++ L +++ ++++ I L+A+ VLH VIHR Sbjct: 94 ----SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHR 149 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 D+K ++L+ + +K+ DFG + + V T ++ APE +++ Sbjct: 150 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSL----------VGTPYWMAPE-LIS 198 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 Y +D+WS G ++ E+ P + + +I + Sbjct: 199 RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL----------------- 241 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 P K +V+P L R+LV DPA+R TA E L+HP+L P Sbjct: 242 ------------PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPA 289 >1PHK-A nrPDB Length = 298 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 83/323 (25%), Positives = 136/323 (42%), Gaps = 60/323 (18%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--------DKPLFALRTL 57 + +++ K +LG G VV HKPT + A+K I+ + TL Sbjct: 12 THGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATL 71 Query: 58 REIKILKHFK-HENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM-LSDDHI 114 +E+ IL+ H NII + D++E +++ +LM+ +L ++ ++ LS+ Sbjct: 72 KEVDILRKVSGHPNIIQL-----KDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKET 126 Query: 115 QYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTG 174 + + L + LH N++HRDLKP N+L++ + ++K+ DFG + +D Sbjct: 127 RKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGE-------- 178 Query: 175 QQSGMTEYVATRWYRAPEVML-----TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 + E T Y APE++ Y + +D+WS G I+ L P F R Sbjct: 179 ---KLREVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQM 235 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 L +I Y P + + DL+ R Sbjct: 236 LMLRMIMS-------------------GNYQFGSPEWDDY---------SDTVKDLVSRF 267 Query: 290 LVFDPAKRITAKEALEHPYLQTY 312 LV P KR TA+EAL HP+ Q Y Sbjct: 268 LVVQPQKRYTAEEALAHPFFQQY 290 >2F57-A nrPDB Length = 317 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 73/300 (24%), Positives = 136/300 (45%), Gaps = 47/300 (15%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +GEG+ G+VC AT K TG+ VA+KK++ + L E+ I++ + H+N++ ++ Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRREL-LFNEVVIMRDYHHDNVVDMY-- 108 Query: 78 QRPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 S+ +E++++ E ++ L +++ ++++ I LRA+ LH VIHR Sbjct: 109 ---SSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHR 165 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 D+K ++L+ S+ +K+ DFG + + V T ++ APEV+ + Sbjct: 166 DIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSL----------VGTPYWMAPEVI-S 214 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 Y +D+WS G ++ E+ P + + I + Sbjct: 215 RLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSL----------------- 257 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 P K +V+ L MLV +P++R TA+E L HP+L+ P+ Sbjct: 258 ------------PPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPS 305 >4B6L-A nrPDB Length = 281 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 77/319 (24%), Positives = 122/319 (38%), Gaps = 54/319 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKHEN 70 + LLG+G + AT TG A+K I KP + L EI++ + +H + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM-QTDLHRV-ISTQMLSDDHIQYFIYQTLRAVKVL 128 I+ FE+ + +YI EL + L + + L + ++Y++ Q L +K L Sbjct: 71 IVRF-----SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYL 125 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H ++HRDLK N I N +LKV DFGLA ++ + T Y Sbjct: 126 HQRGILHRDLKLGNFFITENMELKVGDFGLAARLEP----------PEQRKKTICGTPNY 175 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 APEV+L + DVWS GC++ L P F D + I + T + Sbjct: 176 VAPEVLLRQG-HGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPA---- 230 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 ++ LL +L P R + + L H + Sbjct: 231 ----------------------------SLSLPARQLLAAILRASPRDRPSIDQILRHDF 262 Query: 309 LQTYHDPNDEP--EGEPIP 325 + P+ P +P Sbjct: 263 FTKGYTPDRLPISSCVTVP 281 >4LG4-A nrPDB Length = 299 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 71/301 (23%), Positives = 130/301 (43%), Gaps = 51/301 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 F + LGEG+YG V A HK +G++VAIK++ ++EI I++ ++ Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV---ESDLQEIIKEISIMQQCDSPYVV 69 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHR---VISTQMLSDDHIQYFIYQTLRAVKVLH 129 + S+ +++I+ E + + L +D I + TL+ ++ LH Sbjct: 70 KYYG-----SYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLH 124 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 IHR++K N+L+N+ K+ DFG+A + ++ A + + T ++ Sbjct: 125 FMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRN----------TVIGTPFWM 174 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLR 249 APEV+ Y+ D+WS G E+ +P + H + IF I P Sbjct: 175 APEVIQE-IGYNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNPP------ 224 Query: 250 CIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 P + L + D +++ LV +P +R TA + L+HP++ Sbjct: 225 --------------PTFRKPEL------WSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 264 Query: 310 Q 310 + Sbjct: 265 K 265 >3GUB-A nrPDB Length = 295 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 120/314 (38%), Gaps = 56/314 (17%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA-----LRTLREIKI 62 N+ + LG G + VV K TG A K I+ RE+ I Sbjct: 8 NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSI 67 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQ 120 LK +H N+IT+ + +EN +V +I EL+ + + L+++ F+ Q Sbjct: 68 LKEIQHPNVITLHEV-----YENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQ 122 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNC----DLKVCDFGLARIIDESAADNSEPTGQQ 176 L V LH + H DLKP N+++ +K+ DFGLA ID Sbjct: 123 ILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNE--------- 173 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 T + APE ++ D+WS G I L F G + L + Sbjct: 174 --FKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVS 230 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAK 296 + ++ F + D ++R+LV DP K Sbjct: 231 AV----------------------------NYEFEDEYFSNTSALAKDFIRRLLVKDPKK 262 Query: 297 RITAKEALEHPYLQ 310 R+T +++L+HP+++ Sbjct: 263 RMTIQDSLQHPWIK 276 >3DB8-A nrPDB Length = 317 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 81/323 (25%), Positives = 134/323 (41%), Gaps = 53/323 (16%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLREIKILKHFKH 68 + LG+G + T T E+ A K + KP + EI I K + Sbjct: 42 KRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDN 101 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQ--TDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 +++ FE+ + VY++ E+ + + L + +++ +YF+ QT++ V+ Sbjct: 102 PHVVGFHGF-----FEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQ 156 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH + VIHRDLK NL +N + D+K+ DFGLA I+ + T Sbjct: 157 YLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKK----------DLCGTP 206 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APEV+ +S +D+WS GCIL L + +P F + + I Sbjct: 207 NYIAPEVL-CKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRI----------- 254 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 ++ S+P + +NP L++RML DP R + E L Sbjct: 255 ----------KKNEYSVPRH-----------INPVASALIRRMLHADPTLRPSVAELLTD 293 Query: 307 PYLQTYHDPNDEPE-GEPIPPSF 328 + + + P P +PP F Sbjct: 294 EFFTSGYAPMRLPTSCLTVPPRF 316 >3UDB-A nrPDB Length = 317 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 80/344 (23%), Positives = 130/344 (37%), Gaps = 51/344 (14%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 S ++L +G G +GV K E+VA+K IE +K REI + +H Sbjct: 18 SDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEK--IDENVKREIINHRSLRHP 75 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NI+ + + + I+ E R+ + S+D ++F Q + V Sbjct: 76 NIVRFKEVILTPT-----HLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 Query: 128 LHGSNVIHRDLKPSNLLINSNC--DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 H V HRDLK N L++ + LK+ DFG ++ + S V T Sbjct: 131 AHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSK-----------ASVLHSQPKSAVGT 179 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Y APEV+L + DVWSCG L + + F + Sbjct: 180 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIH-------- 231 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 R ++P Y ++P+ L+ R+ V DPAKRI+ E Sbjct: 232 ---------RILNVQYAIPDYV---------HISPECRHLISRIFVADPAKRISIPEIRN 273 Query: 306 HPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWN 349 H + + P D + F E D + + +++ ++I Sbjct: 274 HEWFLK-NLPADLMNDNTMTTQFDESDQPGQ--SIEEIMQIIAE 314 >3Q53-A nrPDB Length = 306 Score = 236 bits (603), Expect = 9e-63, Method: Composition-based stats. Identities = 79/307 (25%), Positives = 136/307 (44%), Gaps = 47/307 (15%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 V + + +G+GA G V +A TG+ VAI+++ +P L + EI +++ Sbjct: 16 VGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKEL-IINEILVMRE 74 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDHIQYFIYQTLRA 124 K+ NI+ DS+ +E++++ E + L V++ + + I + L+A Sbjct: 75 NKNPNIVNYL-----DSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQA 129 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 ++ LH + VIHRD+K N+L+ + +K+ DFG I T +QS + V Sbjct: 130 LEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI----------TPEQSKRSTMVG 179 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 T ++ APEV+ T Y +D+WS G + E+ P + + L LI GTP Sbjct: 180 TPYWMAPEVV-TRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATN-GTPEL 237 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 N +++ D L R L D KR +AKE + Sbjct: 238 QNPE----------------------------KLSAIFRDFLNRCLEMDVEKRGSAKELI 269 Query: 305 EHPYLQT 311 +H +L+ Sbjct: 270 QHQFLKI 276 >6CKI-A nrPDB Length = 316 Score = 236 bits (603), Expect = 9e-63, Method: Composition-based stats. Identities = 78/323 (24%), Positives = 136/323 (42%), Gaps = 33/323 (10%) Query: 13 FQLKS-LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HEN 70 +QL+ +LGEGA+ V + + T + A+K IE R RE+++L + H N Sbjct: 14 YQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG-HIRSRVFREVEMLYQCQGHRN 72 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 + ++ + FE + Y++ E M+ L + + ++ + A+ L Sbjct: 73 V-----LELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFL 127 Query: 129 HGSNVIHRDLKPSNLLINSNCDL---KVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 H + HRDLKP N+L + K+CDFGL I + + T + + + Sbjct: 128 HNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPE---LLTPCGS 184 Query: 186 RWYRAPEVML----TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 Y APEV+ ++ Y + D+WS G IL L P F GR G Sbjct: 185 AEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD--------CGW 236 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 + C +S+ +K + ++ DL+ ++LV D +R++A Sbjct: 237 DRGEACPACQNM-----LFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA 291 Query: 302 EALEHPYLQTYHDPNDEPEGEPI 324 + L+HP++Q N P + Sbjct: 292 QVLQHPWVQGCAPENTLPTPMVL 314 >2Y7J-A nrPDB Length = 365 Score = 236 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 83/315 (26%), Positives = 140/315 (44%), Gaps = 59/315 (18%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-------PFDKPLFALRTLREIKIL 63 + K ++G G VV H+ TG A+K +E P T RE IL Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 64 KHF-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-LSDDHIQYFIYQ 120 + H +IIT+ DS+E+ + ++++ +LM + +L ++ ++ LS+ + + Sbjct: 154 RQVAGHPHIITLI-----DSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRS 208 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 L AV LH +N++HRDLKP N+L++ N +++ DFG + ++ + Sbjct: 209 LLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGE-----------KLR 257 Query: 181 EYVATRWYRAPEVM-----LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLI 235 E T Y APE++ T Y + +D+W+CG IL L P F R L +I Sbjct: 258 ELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMI 317 Query: 236 FGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPA 295 +Y S P + + DL+ R+L DP Sbjct: 318 ME-------------------GQYQFSSPEWDDR---------SSTVKDLISRLLQVDPE 349 Query: 296 KRITAKEALEHPYLQ 310 R+TA++AL+HP+ + Sbjct: 350 ARLTAEQALQHPFFE 364 >6AO5-A nrPDB Length = 362 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 71/301 (23%), Positives = 130/301 (43%), Gaps = 51/301 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 F + LGEG+YG V A HK +G++VAIK++ ++EI I++ ++ Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV---ESDLQEIIKEISIMQQCDSPYVV 68 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHR---VISTQMLSDDHIQYFIYQTLRAVKVLH 129 + S+ +++I+ E + + L +D I + TL+ ++ LH Sbjct: 69 KYYG-----SYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLH 123 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 IHR++K N+L+N+ K+ DFG+A + ++ A + + T ++ Sbjct: 124 FMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRN----------TVIGTPFWM 173 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLR 249 APEV+ Y+ D+WS G E+ +P + H + IF I P Sbjct: 174 APEVIQE-IGYNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNPP------ 223 Query: 250 CIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 P + L + D +++ LV +P +R TA + L+HP++ Sbjct: 224 --------------PTFRKPEL------WSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 263 Query: 310 Q 310 + Sbjct: 264 K 264 >3MV5-A nrPDB Length = 342 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 79/361 (21%), Positives = 141/361 (39%), Gaps = 73/361 (20%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLR 58 M R+ N +F+ LLG+G +G V K TG A+K ++ TL Sbjct: 3 MDPRVTMN---EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT 59 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQY 116 E ++L++ +H + + SF+ + + + E + ++ S+D ++ Sbjct: 60 ENRVLQNSRHPFLTAL-----KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARF 114 Query: 117 FIYQTLRAVKVLHG-SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQ 175 + + + A+ LH NV++RDLK NL+++ + +K+ DFGL + E Sbjct: 115 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK----------EGIKD 164 Query: 176 QSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLI 235 + M + T Y APEV+ + Y RA+D W G ++ E+ R F +D+ LI Sbjct: 165 GATMKTFCGTPEYLAPEVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI 223 Query: 236 FGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR-VNPKGIDLLQRMLVFDP 294 E FPR + P+ LL +L DP Sbjct: 224 LM---------------------------------EEIRFPRTLGPEAKSLLSGLLKKDP 250 Query: 295 AKRI-----TAKEALEHPYL----------QTYHDPNDEPEGEPIPPSFFEFDHYKEALT 339 +R+ AKE ++H + + P +F+ + + +T Sbjct: 251 KQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMIT 310 Query: 340 T 340 Sbjct: 311 I 311 >4JXF-A nrPDB Length = 266 Score = 235 bits (599), Expect = 2e-62, Method: Composition-based stats. Identities = 77/305 (25%), Positives = 135/305 (44%), Gaps = 53/305 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 DF++ +LLG+G++ V A TG VAIK I+ K R E+KI KH Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVIST--QMLSDDHIQYFIYQTLRAV 125 +I+ ++N FE+ N VY++ E+ +++R + + S++ ++F++Q + + Sbjct: 67 PSILELYNY-----FEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGM 121 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 LH ++HRDL SNLL+ N ++K+ DFGLA + T Sbjct: 122 LYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKM----------PHEKHYTLCGT 171 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Y +PE+ T + + DVWS GC+ L + RP F ++ L + Sbjct: 172 PNYISPEIA-TRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV--------- 221 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 +M ++ + DL+ ++L +PA R++ L+ Sbjct: 222 -----------------------LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLD 258 Query: 306 HPYLQ 310 HP++ Sbjct: 259 HPFMS 263 >3RAW-A nrPDB Length = 381 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 91/337 (27%), Positives = 140/337 (41%), Gaps = 26/337 (7%) Query: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGE-IVAIKKIEPFDKPLFALRTLREIKI 62 RI + +++ LGEG +G V G+ VA+K I K A R EI + Sbjct: 44 RIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARL--EINV 101 Query: 63 LKHFKHENI-ITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST---QMLSDDHIQYFI 118 LK K ++ + D F + I EL+ + + Q H+++ Sbjct: 102 LKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMA 161 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSN------CDLKVCDFGLARIIDESAADNSEP 172 YQ A++ LH + + H DLKP N+L ++ + K C+ + AD Sbjct: 162 YQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA 221 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 T T VATR YR PEV+L +++ DVWS GCIL E + +F + R L Sbjct: 222 TFDHEHHTTIVATRHYRPPEVILELG-WAQPCDVWSIGCILFEYYRGFTLFQTHENREHL 280 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSL---------PMYPAAPLEKMFPRVNPK-- 281 +++ I+G S R + + PL+ + + + Sbjct: 281 VMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHV 340 Query: 282 -GIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPND 317 DL++RML FDPA+RIT EAL HP+ Sbjct: 341 QLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEER 377 >6FYV-A nrPDB Length = 337 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 93/326 (28%), Positives = 145/326 (44%), Gaps = 30/326 (9%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKP-TGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 + + +++ LGEGA+G V G VA+K ++ + A R EI++L+H Sbjct: 12 LRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAAR--SEIQVLEHLN 69 Query: 68 H--ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSD---DHIQYFIYQTL 122 N + +Q + F++ V I+ EL+ + I DHI+ YQ Sbjct: 70 STDPNSV-FRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQIC 128 Query: 123 RAVKVLHGSNVIHRDLKPSNLL-INSNCDLKVC-----DFGLARIIDESAADNSEPTGQQ 176 +++ LH + + H DLKP N+L + S+ +K D + D D T Sbjct: 129 QSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDD 188 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 + V+TR YRAPEV+L +S+ DVWS GCIL E +L +F D + L ++ Sbjct: 189 EHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMME 247 Query: 237 GIIGTPH-------------SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI 283 I+G N L E A Y++ P + K Sbjct: 248 RILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCK-PLKEFMLCHDEEHEKLF 306 Query: 284 DLLQRMLVFDPAKRITAKEALEHPYL 309 DL++RML +DP +RIT EAL+HP+ Sbjct: 307 DLVRRMLEYDPTQRITLDEALQHPFF 332 >5KCV-A nrPDB Length = 460 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 73/310 (23%), Positives = 129/310 (41%), Gaps = 60/310 (19%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 ++F+ LLG+G +G V K TG A+K ++ TL E ++L++ +H Sbjct: 162 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH 221 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 + + SF+ + + + E + ++ S+D +++ + + A+ Sbjct: 222 PFLTAL-----KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 276 Query: 127 VLHG-SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 LH NV++RDLK NL+++ + +K+ DFGL + E + M + T Sbjct: 277 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK----------EGIKDGATMKTFCGT 326 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Y APEV+ + Y RA+D W G ++ E+ R F +D+ LI Sbjct: 327 PEYLAPEVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM-------- 377 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPR-VNPKGIDLLQRMLVFDPAKRI-----T 299 E FPR + P+ LL +L DP +R+ Sbjct: 378 -------------------------EEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSED 412 Query: 300 AKEALEHPYL 309 AKE ++H + Sbjct: 413 AKEIMQHRFF 422 >4L42-A nrPDB Length = 346 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 76/347 (21%), Positives = 139/347 (40%), Gaps = 63/347 (18%) Query: 11 SDFQLKSLLGEGAYGVVCSATHK---PTGEIVAIKKIEPF---DKPLFALRTLREIKILK 64 F+L +LG+G YG V TG+I A+K ++ T E IL+ Sbjct: 18 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 77 Query: 65 HFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTL 122 KH I+ + +F+ ++Y+I E + ++ + +D +++ + Sbjct: 78 EVKHPFIVDLI-----YAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS 132 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 A+ LH +I+RDLKP N+++N +K+ DFGL + E + + Sbjct: 133 MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCK----------ESIHDGTVTHTF 182 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 T Y APE+++ S ++RA+D WS G ++ ++ P F G + + + I Sbjct: 183 CGTIEYMAPEILMRSG-HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK----- 236 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI---- 298 + P + + DLL+++L + A R+ Sbjct: 237 ---------------------------CKLNLPPYLTQEARDLLKKLLKRNAASRLGAGP 269 Query: 299 -TAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLK 344 A E HP+ + H +E + P F +E ++ D K Sbjct: 270 GDAGEVQAHPFFR--HINWEELLARKVEPPFKPLLQSEEDVSQFDSK 314 >2OU7-A nrPDB Length = 335 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 130/315 (41%), Gaps = 53/315 (16%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKHENIITIFN 76 LG+G + + T E+ A K + KP + EI I + H++++ Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 77 IQRPDSFENFNEVYIIQELMQ--TDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVI 134 FE+ + V+++ EL + + L + L++ +Y++ Q + + LH + VI Sbjct: 109 F-----FEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVI 163 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 HRDLK NL +N + ++K+ DFGLA ++ T Y APEV+ Sbjct: 164 HRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVL----------CGTPNYIAPEVL 213 Query: 195 LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESP 254 +S +DVWS GCI+ L + +P F + L I Sbjct: 214 SKKG-HSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRI------------------- 253 Query: 255 RAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHD 314 ++ S+P + +NP L+Q+ML DP R T E L + + + Sbjct: 254 --KKNEYSIPKH-----------INPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYI 300 Query: 315 PNDEP-EGEPIPPSF 328 P P IPP F Sbjct: 301 PARLPITCLTIPPRF 315 >4KS7-A nrPDB Length = 292 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 75/300 (25%), Positives = 134/300 (44%), Gaps = 47/300 (15%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNI 77 +GEG+ G+VC A K +G VA+K ++ + L E+ I++ ++H N++ ++ Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRREL-LFNEVVIMRDYQHFNVVEMY-- 86 Query: 78 QRPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 S+ E++++ E +Q L ++S L+++ I L+A+ LH VIHR Sbjct: 87 ---KSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHR 143 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 D+K ++L+ + +K+ DFG I + V T ++ APEV+ + Sbjct: 144 DIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSL----------VGTPYWMAPEVI-S 192 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 + Y+ +D+WS G ++ E+ P + + + Sbjct: 193 RSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRL--------------------- 231 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 P K +V+P D L+RMLV DP +R TA+E L+HP+L P Sbjct: 232 --------RDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPE 283 >5D9K-A nrPDB Length = 330 Score = 234 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 72/342 (21%), Positives = 139/342 (40%), Gaps = 71/342 (20%) Query: 11 SDFQLKSLLGEGAYGVVCSATHK---PTGEIVAIKKIEPFD-KPLFALRTLREIKILKHF 66 S F+L +LG+G++G V ++ A+K ++ K +RT E IL Sbjct: 30 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEV 89 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRA 124 H I+ + +F+ ++Y+I + ++ R+ M +++ +++++ + A Sbjct: 90 NHPFIVKLH-----YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 144 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + LH +I+RDLKP N+L++ +K+ DFGL++ E + + Sbjct: 145 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSK----------ESIDHEKKAYSFCG 194 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG-IIGTPH 243 T Y APEV+ ++++ D WS G ++ E+ F G+D + + +I +G P Sbjct: 195 TVEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQ 253 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA--- 300 ++P+ LL+ + +PA R+ A Sbjct: 254 F---------------------------------LSPEAQSLLRMLFKRNPANRLGAGPD 280 Query: 301 --KEALEHPYLQT----------YHDPNDEPEGEPIPPSFFE 330 +E H + T H P G P +F+ Sbjct: 281 GVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFD 322 >2JDO-A nrPDB Length = 342 Score = 233 bits (595), Expect = 7e-62, Method: Composition-based stats. Identities = 74/336 (22%), Positives = 140/336 (41%), Gaps = 63/336 (18%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLR 58 M ++ N DF LLG+G +G V K TG A+K + T+ Sbjct: 3 MDPKVTMN---DFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVT 59 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQY 116 E ++L++ +H + + +F+ + + + E + ++ +++ ++ Sbjct: 60 ESRVLQNTRHPFLTAL-----KYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARF 114 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 + + + A++ LH +V++RD+K NL+++ + +K+ DFGL + E Sbjct: 115 YGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCK----------EGISDG 164 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 + M + T Y APEV+ + Y RA+D W G ++ E+ R F +D+ LI Sbjct: 165 ATMKTFCGTPEYLAPEVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL 223 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR-VNPKGIDLLQRMLVFDPA 295 E FPR ++P+ LL +L DP Sbjct: 224 M---------------------------------EEIRFPRTLSPEAKSLLAGLLKKDPK 250 Query: 296 KRI-----TAKEALEHPYLQTYHDPNDEPEGEPIPP 326 +R+ AKE +EH + + + D + + +PP Sbjct: 251 QRLGGGPSDAKEVMEHRFFLSINW-QDVVQKKLLPP 285 >2A27-A nrPDB Length = 321 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 79/358 (22%), Positives = 132/358 (36%), Gaps = 60/358 (16%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA-----LR 55 M + + + LG G + +V K TG A K I+ Sbjct: 2 MEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREE 61 Query: 56 TLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDH 113 RE+ IL+ H N+IT+ ++ +EN +V +I EL+ + + LS++ Sbjct: 62 IEREVSILRQVLHHNVITLHDV-----YENRTDVVLILELVSGGELFDFLAQKESLSEEE 116 Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNC----DLKVCDFGLARIIDESAADN 169 FI Q L V LH + H DLKP N+++ +K+ DFGLA I++ Sbjct: 117 ATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-- 174 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 T + APE ++ D+WS G I L F G + Sbjct: 175 ---------FKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQ 224 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 L I + Y E+ F + + D ++++ Sbjct: 225 ETLANITAV-------------------SYDFD---------EEFFSQTSELAKDFIRKL 256 Query: 290 LVFDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLI 347 LV + KR+T +EAL HP++ P D + S +++++ + K Sbjct: 257 LVKETRKRLTIQEALRHPWIT----PVDNQQAMVRRESVVNLENFRKQYVRRRSKLAF 310 >4J52-A nrPDB Length = 293 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 130/315 (41%), Gaps = 53/315 (16%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKHENIITIFN 76 LG+G + + T E+ A K + KP + EI I + H++++ Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 77 IQRPDSFENFNEVYIIQELMQ--TDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVI 134 FE+ + V+++ EL + + L + L++ +Y++ Q + + LH + VI Sbjct: 82 F-----FEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVI 136 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 HRDLK NL +N + ++K+ DFGLA ++ T Y APEV+ Sbjct: 137 HRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVL----------CGTPNYIAPEVL 186 Query: 195 LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESP 254 +S +DVWS GCI+ L + +P F + L I Sbjct: 187 SKKG-HSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRI------------------- 226 Query: 255 RAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHD 314 ++ S+P + +NP L+Q+ML DP R T E L + + + Sbjct: 227 --KKNEYSIPKH-----------INPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYI 273 Query: 315 PNDEP-EGEPIPPSF 328 P P IPP F Sbjct: 274 PARLPITCLTIPPRF 288 >4QMW-A nrPDB Length = 310 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 64/298 (21%), Positives = 121/298 (40%), Gaps = 48/298 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 F +G+G++G V T ++VAIK I+ + +EI +L + Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 90 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDL-HRVISTQMLSDDHIQYFIYQTLRAVKVLHGS 131 + S+ +++II E + ++ L + I + + L+ + LH Sbjct: 91 KYYG-----SYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 145 Query: 132 NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 IHRD+K +N+L++ + ++K+ DFG+A + ++ + +V T ++ AP Sbjct: 146 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRN----------TFVGTPFWMAP 195 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCI 251 EV+ SA Y D+WS G EL P H + Sbjct: 196 EVIKQSA-YDSKADIWSLGITAIELARGEPP---HSELHPM------------------- 232 Query: 252 ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 + + +P LE + + + ++ L +P+ R TAKE L+H ++ Sbjct: 233 ------KVLFLIPKNNPPTLEGNY---SKPLKEFVEACLNKEPSFRPTAKELLKHKFI 281 >4RLP-A nrPDB Length = 288 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 73/331 (22%), Positives = 133/331 (40%), Gaps = 63/331 (19%) Query: 11 SDFQLKSLLGEGAYGVVCSATHK---PTGEIVAIKKIEPF---DKPLFALRTLREIKILK 64 F+L +LG+G YG V TG+I A+K ++ T E IL+ Sbjct: 5 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 64 Query: 65 HFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTL 122 KH I+ + +F+ ++Y+I E + ++ + +D +++ + Sbjct: 65 EVKHPFIVDLI-----YAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS 119 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 A+ LH +I+RDLKP N+++N +K+ DFGL + E + + Sbjct: 120 MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCK----------ESIHDGTVTHTF 169 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 T Y APE+++ S ++RA+D WS G ++ ++ P F G + + + I Sbjct: 170 CGTIEYMAPEILMRSG-HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK----- 223 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI---- 298 + P + + DLL+++L + A R+ Sbjct: 224 ---------------------------CKLNLPPYLTQEARDLLKKLLKRNAASRLGAGP 256 Query: 299 -TAKEALEHPYLQTYHDPNDEPEGEPIPPSF 328 A E HP+ + H +E + P F Sbjct: 257 GDAGEVQAHPFFR--HINWEELLARKVEPPF 285 >2XIK-A nrPDB Length = 294 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 119/301 (39%), Gaps = 48/301 (15%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 F +G+G++G V T E+VAIK I+ + +EI +L I Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYIT 80 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDL-HRVISTQMLSDDHIQYFIYQTLRAVKVLHGS 131 F S+ +++II E + ++ L + +I + + L+ + LH Sbjct: 81 RYFG-----SYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSE 135 Query: 132 NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 IHRD+K +N+L++ D+K+ DFG+A + ++ + +V T ++ AP Sbjct: 136 RKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRN----------TFVGTPFWMAP 185 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCI 251 EV+ SA Y D+WS G EL P L LI Sbjct: 186 EVIKQSA-YDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPK-------------- 230 Query: 252 ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQT 311 SP E S P + ++ L DP R TAKE L+H ++ Sbjct: 231 NSPPTLEGQHSKP-----------------FKEFVEACLNKDPRFRPTAKELLKHKFITR 273 Query: 312 Y 312 Y Sbjct: 274 Y 274 >6FDY-U nrPDB Length = 276 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 88/310 (28%), Positives = 133/310 (42%), Gaps = 52/310 (16%) Query: 13 FQLKSLLGEGAYGVVCSAT-HKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHEN 70 F L LG G Y V A K T E+VAIK + + L EI+ILK +H + Sbjct: 13 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPH 72 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-LSDDHIQYFIYQTLRAVKVL 128 I+ + + Q + + +Y+I E DL R I T+ L + + F+ Q A++ L Sbjct: 73 IVQLKDFQW-----DSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFL 127 Query: 129 HGSNVIHRDLKPSNLLIN--SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H N+ H DLKP N+L++ LK+ DFG A+ + + + Sbjct: 128 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLR-----------GSP 176 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APE M+ +Y +D+WS G IL E +P F R + I Sbjct: 177 LYMAPE-MVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSN-------- 227 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 R IE P P ++ DLLQR+L DP++RI+ ++ H Sbjct: 228 --RVIELPLR-------------------PLLSRDCRDLLQRLLERDPSRRISFQDFFAH 266 Query: 307 PYLQTYHDPN 316 P++ H P+ Sbjct: 267 PWVDLEHMPS 276 >5D7A-A nrPDB Length = 308 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 72/340 (21%), Positives = 132/340 (38%), Gaps = 54/340 (15%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 + + + + F+L L+G G YG V H TG++ AIK ++ +EI Sbjct: 7 IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDE--EEEIKQEI 64 Query: 61 KILKHF-KHENIITIFN-IQRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHI 114 +LK + H NI T + + + ++++++ E TDL + L ++ I Sbjct: 65 NMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWI 124 Query: 115 QYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTG 174 Y + LR + LH VIHRD+K N+L+ N ++K+ DFG++ +D + + Sbjct: 125 AYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRN---- 180 Query: 175 QQSGMTEYVATRWYRAPEVMLTSAK----YSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 ++ T ++ APEV+ Y D+WS G E+ P Sbjct: 181 ------TFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 234 Query: 231 QLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRML 290 L LI P + K F ++ L Sbjct: 235 ALFLIPR-----------------------NPAPRLKSKKWSKKFQS-------FIESCL 264 Query: 291 VFDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFE 330 V + ++R ++ ++HP+++ PN+ + Sbjct: 265 VKNHSQRPATEQLMKHPFIRD--QPNERQVRIQLKDHIDR 302 >6CMJ-A nrPDB Length = 321 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 77/326 (23%), Positives = 137/326 (42%), Gaps = 57/326 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA----------LRTLREI 60 + LK +G+G+YGVV A ++ A+K + A + +EI Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEI 93 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIY 119 ILK H N++ + + N + +Y++ EL+ + V + + LS+D +++ Sbjct: 94 AILKKLDHPNVVKLVEVLDDP---NEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQ 150 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 ++ ++ LH +IHRD+KPSNLL+ + +K+ DFG++ +E G + + Sbjct: 151 DLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVS----------NEFKGSDALL 200 Query: 180 TEYVATRWYRAPEVMLTSAKY--SRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 + V T + APE + + K +A+DVW+ G L + F Sbjct: 201 SNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-------------- 246 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 D + C+ S + + +P P + DL+ RML +P R Sbjct: 247 ------MDERIMCLHSKIKSQAL----EFPDQ------PDIAEDLKDLITRMLDKNPESR 290 Query: 298 ITAKEALEHPYLQTYHDPNDEPEGEP 323 I E HP++ T H P + Sbjct: 291 IVVPEIKLHPWV-TRHGAEPLPSEDE 315 >4FZF-B nrPDB Length = 283 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 64/298 (21%), Positives = 113/298 (37%), Gaps = 48/298 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 F +G+G++G V T ++VAIK I+ + +EI +L + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 69 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDL-HRVISTQMLSDDHIQYFIYQTLRAVKVLHGS 131 + S+ ++++II E + ++ + I + + L+ + LH Sbjct: 70 KYYG-----SYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSE 124 Query: 132 NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 IHRD+K +N+L++ D+K+ FG+A + ++ + +V T ++ AP Sbjct: 125 KKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRN----------TFVGTPFWMAP 174 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCI 251 EV+ SA Y D+WS G EL P L LI Sbjct: 175 EVIQQSA-YDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLI---------------- 217 Query: 252 ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 P + + + L DP+ R TAKE L+H ++ Sbjct: 218 ---------------PKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 260 >4C0T-A nrPDB Length = 974 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 84/350 (24%), Positives = 149/350 (42%), Gaps = 46/350 (13%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLREI 60 K I N++ DF+ LGEG+Y V AT K TG+ A+K ++ K E Sbjct: 259 KTIRRNVT-DFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEK 317 Query: 61 KILKHFKHE-NIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIST-QMLSDDHIQYF 117 L + +I+++ +F++ + +Y + + +L +I L+++ ++F Sbjct: 318 HALNRLSNRLGVISLY-----FTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHF 372 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 Q L A+K +H + VIHRDLKP N+L++ +++ DFG AR++ E D SE Sbjct: 373 GAQILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLL-EKKNDESEEYPVDV 431 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 +V T Y +PE +L + + DVW+ GCI+ ++ +P F + I Sbjct: 432 RAKSFVGTAEYVSPE-LLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITK 490 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 + FP + DL++++LV P++R Sbjct: 491 L-----------------------------QFAFSAGFPTI---IRDLIKKILVLQPSRR 518 Query: 298 ITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHY-KEALTTKDLKKL 346 T E +H + Q+ + + PP + K + +L K Sbjct: 519 ATIPEIQKHYFFQSVDFKDFDSIWLSDPPEIGPYKMTAKSMMKVPELNKA 568 >1ZWS-A nrPDB Length = 288 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 75/320 (23%), Positives = 120/320 (37%), Gaps = 56/320 (17%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA-----LR 55 M + + + LG G + +V K TG A K I+ Sbjct: 2 MEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREE 61 Query: 56 TLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDH 113 RE+ IL+ H N+IT+ ++ +EN +V +I EL+ + + LS++ Sbjct: 62 IEREVSILRQVLHHNVITLHDV-----YENRTDVVLILELVSGGELFDFLAQKESLSEEE 116 Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNC----DLKVCDFGLARIIDESAADN 169 FI Q L V LH + H DLKP N+++ +K+ DFGLA I++ Sbjct: 117 ATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-- 174 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 T + APE ++ D+WS G I L F G + Sbjct: 175 ---------FKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQ 224 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 L I + Y E+ F + D ++++ Sbjct: 225 ETLANITSV-------------------SYDFD---------EEFFSHTSELAKDFIRKL 256 Query: 290 LVFDPAKRITAKEALEHPYL 309 LV + KR+T +EAL HP++ Sbjct: 257 LVKETRKRLTIQEALRHPWI 276 >2Z7Q-A nrPDB Length = 321 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 70/330 (21%), Positives = 135/330 (40%), Gaps = 63/330 (19%) Query: 11 SDFQLKSLLGEGAYGVVCSATHK---PTGEIVAIKKIEPFD-KPLFALRTLREIKILKHF 66 S F+L +LG+G++G V +G + A+K ++ K +RT E IL Sbjct: 28 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADV 87 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRA 124 H ++ + +F+ ++Y+I + ++ R+ M +++ +++++ + Sbjct: 88 NHPFVVKLH-----YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALG 142 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + LH +I+RDLKP N+L++ +K+ DFGL++ E + + Sbjct: 143 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSK----------EAIDHEKKAYSFCG 192 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG-IIGTPH 243 T Y APEV+ +S + D WS G ++ E+ F G+D + + LI +G P Sbjct: 193 TVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQ 251 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI----- 298 ++ + LL+ + +PA R+ Sbjct: 252 F---------------------------------LSTEAQSLLRALFKRNPANRLGSGPD 278 Query: 299 TAKEALEHPYLQTYHDPNDEPEGEPIPPSF 328 A+E H + T ++ I P F Sbjct: 279 GAEEIKRHVFYSTI--DWNKLYRREIKPPF 306 >3KN6-A nrPDB Length = 325 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 81/340 (23%), Positives = 131/340 (38%), Gaps = 60/340 (17%) Query: 17 SLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HENIITIF 75 LGEG++ + HK + + A+K I T +EI LK + H NI+ + Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISK----RMEANTQKEITALKLCEGHPNIVKLH 72 Query: 76 NIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNV 133 + F + +++ EL+ R+ + S+ Y + + + AV +H V Sbjct: 73 EV-----FHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 127 Query: 134 IHRDLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRA 190 +HRDLKP NLL N N ++K+ DFG AR+ P T Y A Sbjct: 128 VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCF----------TLHYAA 177 Query: 191 PEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRC 250 PE +L Y + D+WS G IL + + F D R Sbjct: 178 PE-LLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHD---------------------RS 215 Query: 251 IESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 + A E +K + + + + V+ + DL+Q +L DP KR+ + +LQ Sbjct: 216 LTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQ 275 Query: 311 TYHDPNDEPEGEP-------------IPPSFFEFDHYKEA 337 + P P + +F F+ YK Sbjct: 276 DGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKRE 315 >3UTO-A nrPDB Length = 573 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 73/343 (21%), Positives = 132/343 (38%), Gaps = 54/343 (15%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 ++ + + LG GA+GVV T + TG A K + +EI+ + + Sbjct: 154 HVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV-MTPHESDKETVRKEIQTMSVLR 212 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQ-MLSDDHIQYFIYQTLRA 124 H ++ + D+FE+ NE+ +I E M +V +S+D ++ Q + Sbjct: 213 HPTLVNLH-----DAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKG 267 Query: 125 VKVLHGSNVIHRDLKPSNLLINS--NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + +H +N +H DLKP N++ + + +LK+ DFGL +D + Sbjct: 268 LCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT---------- 317 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 T + APEV D+WS G + L F G + L Sbjct: 318 -GTAEFAAPEVA-EGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETL---------- 365 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 +++ + F ++ G D ++++L+ DP R+T + Sbjct: 366 ------------------RNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQ 407 Query: 303 ALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKK 345 ALEHP+L + P + + IP S + + Sbjct: 408 ALEHPWLTPGNAPGRDSQ---IPSSRYTKIRDSIKTKYDAWPE 447 >2UV2-A nrPDB Length = 325 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 79/309 (25%), Positives = 123/309 (39%), Gaps = 52/309 (16%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 N +++ LG+GA+G V A +K T + A K I+ + EI IL Sbjct: 34 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVID-TKSEEELEDYMVEIDILASCD 92 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHR---VISTQMLSDDHIQYFIYQTLRA 124 H NI+ + D+F N ++I+ E + + L++ IQ QTL A Sbjct: 93 HPNIVKLL-----DAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDA 147 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + LH + +IHRDLK N+L + D+K+ DFG++ T ++ Sbjct: 148 LNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAK----------NTRTIQRRDSFIG 197 Query: 185 TRWYRAPEVML----TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 T ++ APEV++ Y DVWS G L E+ P + LL I Sbjct: 198 TPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIA---- 253 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 KS P A P R + D L++ L + R T Sbjct: 254 --------------------KSEPPTLAQP-----SRWSSNFKDFLKKCLEKNVDARWTT 288 Query: 301 KEALEHPYL 309 + L+HP++ Sbjct: 289 SQLLQHPFV 297 >4YNZ-A nrPDB Length = 342 Score = 227 bits (580), Expect = 5e-60, Method: Composition-based stats. Identities = 74/318 (23%), Positives = 131/318 (41%), Gaps = 54/318 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHENI 71 ++L+ LG+G G+V H T + VAIK + ++ REI ILK +H ++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 + + ++ +EN +Y++ E + ++ L+ + F Q + A+ H Sbjct: 72 LKLHDV-----YENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCH 126 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 ++ HRDLKP NLL++ ++++ DFG+A + + + + Y Sbjct: 127 SHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETS-----------CGSPHYA 175 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLR 249 PEV+ R DVWSCG IL L + F + R L Sbjct: 176 CPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLL----------------- 218 Query: 250 CIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 + + + +P + + P LL+ M+ D A+R+T + +H + Sbjct: 219 ----EKVKRGVFHMPHF-----------IPPDCQSLLRGMIEVDAARRLTLEHIQKHIW- 262 Query: 310 QTYHDPNDEPEGEPIPPS 327 Y +EPE E P Sbjct: 263 --YIGGKNEPEPEQPIPR 278 >3HKO-A nrPDB Length = 345 Score = 227 bits (579), Expect = 5e-60, Method: Composition-based stats. Identities = 81/358 (22%), Positives = 135/358 (37%), Gaps = 88/358 (24%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD----KPLFALRTLREIK 61 + + + LK +G+G+YGVV A T I AIK + P R E++ Sbjct: 21 LLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVR 80 Query: 62 ILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-----------------LHRVI 104 ++K H NI ++ + +E+ + ++ EL V+ Sbjct: 81 LMKKLHHPNIARLYEV-----YEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVV 135 Query: 105 STQMLS-------------------------DDHIQYFIYQTLRAVKVLHGSNVIHRDLK 139 TQ+ + I + Q A+ LH + HRD+K Sbjct: 136 KTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIK 195 Query: 140 PSNLLINSN--CDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVML-T 196 P N L ++N ++K+ DFGL++ G+ GMT T ++ APEV+ T Sbjct: 196 PENFLFSTNKSFEIKLVDFGLSKEF------YKLNNGEYYGMTTKAGTPYFVAPEVLNTT 249 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 + Y D WS G +L L + FPG + + + N C E+P Sbjct: 250 NESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVL---------NKKLCFENP-- 298 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHD 314 + ++P DLL +L + +R A AL+HP++ + D Sbjct: 299 -----------------NYNVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSD 339 >1VZO-A nrPDB Length = 355 Score = 227 bits (578), Expect = 6e-60, Method: Composition-based stats. Identities = 73/338 (21%), Positives = 144/338 (42%), Gaps = 57/338 (16%) Query: 11 SDFQLKSLLGEGAYGVVCSATH---KPTGEIVAIKKIEPF---DKPLFALRTLREIKILK 64 +F+L +LG GAYG V TG++ A+K ++ K T E ++L+ Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 65 HFK-HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQT 121 H + ++T+ +F+ ++++I + + + + ++ +Q ++ + Sbjct: 114 HIRQSPFLVTLH-----YAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 168 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 + A++ LH +I+RD+K N+L++SN + + DFGL++ + + + Sbjct: 169 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERA---------YD 219 Query: 182 YVATRWYRAPEVMLTS-AKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 + T Y AP+++ + + +A+D WS G ++ EL F ++ I Sbjct: 220 FCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEI----- 274 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI-- 298 +R +KS P YP ++ DL+QR+L+ DP KR+ Sbjct: 275 ---------------SRRILKSEPPYPQ--------EMSALAKDLIQRLLMKDPKKRLGC 311 Query: 299 ---TAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDH 333 A E EH + Q + + + P P D Sbjct: 312 GPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDE 349 >5F9E-A nrPDB Length = 353 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 71/324 (21%), Positives = 137/324 (42%), Gaps = 56/324 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP--FDKPLFALRTLREIKILKH-FK 67 DF+L +LG+G++G V A K T + AIK ++ T+ E ++L ++ Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWE 78 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H + +F +F+ ++ + E + ++ + S ++ + + + Sbjct: 79 HPFLTHMFC-----TFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGL 133 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 + LH +++RDLK N+L++ + +K+ DFG+ + E + E+ T Sbjct: 134 QFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCK----------ENMLGDAKTNEFCGT 183 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Y APE++L KY+ ++D WS G +L E+ + + F G+D I Sbjct: 184 PDYIAPEILLGQ-KYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRM-------- 234 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK-EAL 304 P YP + + DLL ++ V +P KR+ + + Sbjct: 235 ----------------DNPFYPRWLEK--------EAKDLLVKLFVREPEKRLGVRGDIR 270 Query: 305 EHPYLQTYHDPNDEPEGEPIPPSF 328 +HP + + +E E + I P F Sbjct: 271 QHPLFREIN--WEELERKEIDPPF 292 >3HDN-A nrPDB Length = 373 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 71/334 (21%), Positives = 128/334 (38%), Gaps = 58/334 (17%) Query: 2 PKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLRE 59 P + SDF ++G+G++G V A HK A+K ++ K + E Sbjct: 29 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 88 Query: 60 IKIL-KHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQY 116 +L K+ KH ++ + SF+ +++Y + + + + + + + ++ Sbjct: 89 RNVLLKNVKHPFLVGLH-----FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARF 143 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 + + A+ LH N+++RDLKP N+L++S + + DFGL + E Sbjct: 144 YAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCK----------ENIEHN 193 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 S + + T Y APEV+ Y R +D W G +L E+ P F R+ I Sbjct: 194 STTSTFCGTPEYLAPEVL-HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNIL 252 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAK 296 ++ P + LL+ +L D K Sbjct: 253 N--------------------------------KPLQLKPNITNSARHLLEGLLQKDRTK 280 Query: 297 RITAK----EALEHPYLQTYHDPNDEPEGEPIPP 326 R+ AK E H + + +D + PP Sbjct: 281 RLGAKDDFMEIKSHVFFSLINW-DDLINKKITPP 313 >5J5T-A nrPDB Length = 370 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 77/307 (25%), Positives = 130/307 (42%), Gaps = 49/307 (15%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 DF+L +G G YG V A + TGE+ AIK I+ FA+ +EI ++K KH Sbjct: 3 QEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-VQQEIIMMKDCKHP 61 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIS-TQMLSDDHIQYFIYQTLRAVKV 127 NI+ F S+ ++++I E L + T LS+ I Y +TL+ + Sbjct: 62 NIVAYFG-----SYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYY 116 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 LH +HRD+K +N+L+ N +K+ DFG++ I + A ++ T + Sbjct: 117 LHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRK----------AFIGTPY 166 Query: 188 YRAPEV--MLTSAKYSRAMDVWSCGCILAELFLRRPI-FPGRDYRHQLLLIFGIIGTPHS 244 + APEV + Y++ D+W+ G EL +P F R L+ P Sbjct: 167 WMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKL 226 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 + ++ + ++ L +P KR TA++ L Sbjct: 227 KDKMKW----------------------------SNSFHHFVKMALTKNPKKRPTAEKLL 258 Query: 305 EHPYLQT 311 +HP++ Sbjct: 259 QHPFVTQ 265 >1KOA-A nrPDB Length = 491 Score = 225 bits (575), Expect = 1e-59, Method: Composition-based stats. Identities = 73/343 (21%), Positives = 132/343 (38%), Gaps = 54/343 (15%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 ++ + + LG GA+GVV T + TG A K + +EI+ + + Sbjct: 48 HVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV-MTPHESDKETVRKEIQTMSVLR 106 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQ-MLSDDHIQYFIYQTLRA 124 H ++ + D+FE+ NE+ +I E M +V +S+D ++ Q + Sbjct: 107 HPTLVNLH-----DAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKG 161 Query: 125 VKVLHGSNVIHRDLKPSNLLINS--NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + +H +N +H DLKP N++ + + +LK+ DFGL +D + Sbjct: 162 LCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT---------- 211 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 T + APEV D+WS G + L F G + L Sbjct: 212 -GTAEFAAPEVA-EGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETL---------- 259 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 +++ + F ++ G D ++++L+ DP R+T + Sbjct: 260 ------------------RNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQ 301 Query: 303 ALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKK 345 ALEHP+L + P + + IP S + + Sbjct: 302 ALEHPWLTPGNAPGRDSQ---IPSSRYTKIRDSIKTKYDAWPE 341 >5YV8-A nrPDB Length = 298 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 74/327 (22%), Positives = 134/327 (40%), Gaps = 71/327 (21%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA----------------- 53 + + LK +G+G+YGVV A ++ A+K + A Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 54 --------LRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVI 104 + +EI ILK H N++ + + N + +Y++ EL+ + V Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDP---NEDHLYMVFELVNQGPVMEVP 129 Query: 105 STQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDE 164 + + LS+D +++ ++ ++ LH +IHRD+KPSNLL+ + +K+ DFG++ Sbjct: 130 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVS----- 184 Query: 165 SAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKY--SRAMDVWSCGCILAELFLRRPI 222 +E G + ++ V T + APE + + K +A+DVW+ G L + Sbjct: 185 -----NEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCP 239 Query: 223 FPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKG 282 F D + C+ S + + +P P + Sbjct: 240 F--------------------MDERIMCLHSKIKSQAL----EFPDQ------PDIAEDL 269 Query: 283 IDLLQRMLVFDPAKRITAKEALEHPYL 309 DL+ RML +P RI E HP++ Sbjct: 270 KDLITRMLDKNPESRIVVPEIKLHPWV 296 >5UNP-A nrPDB Length = 369 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 86/334 (25%), Positives = 142/334 (42%), Gaps = 26/334 (7%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSAT-HKPTGEIVAIKKIEPFDKPLFALRTLREIKIL 63 + + +++ S LGEG +G V H+ G VA+K I+ +K A R EI +L Sbjct: 28 VGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARL--EINVL 85 Query: 64 KHFKHENI-ITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ---MLSDDHIQYFIY 119 + ++ +Q D F+ + I EL+ + +++ + Sbjct: 86 EKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAF 145 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLL-INSNCDL-----KVCDFGLARIIDESAADNSEPT 173 Q +AVK LH + + H DLKP N+L +NS+ +L K D + D T Sbjct: 146 QLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT 205 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLL 233 + V+TR YRAPEV+L +S+ DVWS GCI+ E ++ +F D R L Sbjct: 206 FDHEHHSTIVSTRHYRAPEVILELG-WSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLA 264 Query: 234 LIFGIIGTPHSDNDLRCIESPRAREYIKSL------PMYPAAPLEKMFPRVNPKG----- 282 ++ I+G S + + Y + + + + Sbjct: 265 MMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQ 324 Query: 283 -IDLLQRMLVFDPAKRITAKEALEHPYLQTYHDP 315 DL++ ML ++PAKR+T EAL+HP+ Sbjct: 325 LFDLIESMLEYEPAKRLTLGEALQHPFFARLRAE 358 >4I6B-A nrPDB Length = 308 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 65/320 (20%), Positives = 124/320 (38%), Gaps = 52/320 (16%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKI 62 + + LG+G + T ++ A K I KP + +EI++ Sbjct: 22 VDPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIEL 81 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIS-TQMLSDDHIQYFIYQ 120 + H++++ ++ FE+ +YI+ E + + ++ ++L++ ++Y++ Q Sbjct: 82 HRILHHKHVVQFYHY-----FEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQ 136 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 + +K LH ++HRDLK N IN + +LKV DFGLA ++ Sbjct: 137 IVSGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRR---------- 186 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 T Y +PEV+ + D+W+ GC++ + L RP F + + I Sbjct: 187 TICGTPNYLSPEVL-NKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSI----- 240 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 RE ++P AP L+ ML +P R + Sbjct: 241 ----------------REARYTMPSSLLAP-----------AKHLIASMLSKNPEDRPSL 273 Query: 301 KEALEHPYLQTYHDPNDEPE 320 + + H + P+ Sbjct: 274 DDIIRHDFFTQGFTPDRLSS 293 >2WTK-C nrPDB Length = 305 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 78/343 (22%), Positives = 142/343 (41%), Gaps = 52/343 (15%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDK---PLFALRTLREIKILKHFK 67 + + LLGEG+YG V T A+K ++ P +EI++L+ + Sbjct: 5 GKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLR 64 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI---STQMLSDDHIQYFIYQTLRA 124 H+N+I + ++ E ++Y++ E + ++ + + Q + Sbjct: 65 HKNVIQLVDVLYN---EEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDG 121 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 ++ LH ++H+D+KP NLL+ + LK+ G+A + AAD++ T Q Sbjct: 122 LEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQ--------G 173 Query: 185 TRWYRAPEVMLTSAKYS-RAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 + ++ PE+ +S +D+WS G L + F G Sbjct: 174 SPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEG------------------ 215 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 DN + E+ Y ++P PL DLL+ ML ++PAKR + ++ Sbjct: 216 -DNIYKLFENIGKGSY--AIPGDCGPPLS-----------DLLKGMLEYEPAKRFSIRQI 261 Query: 304 LEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKL 346 +H + + H P + P PIPPS D ++ L+ L Sbjct: 262 RQHSWFRKKHPPAEAP--VPIPPSPDTKDRWRSMTVVPYLEDL 302 >4MD7-E nrPDB Length = 391 Score = 223 bits (568), Expect = 9e-59, Method: Composition-based stats. Identities = 86/314 (27%), Positives = 151/314 (48%), Gaps = 29/314 (9%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILK 64 + + D+QL LG G Y V A + E + KP+ + REIKIL+ Sbjct: 31 VEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK----VVVKILKPVKKKKIKREIKILE 86 Query: 65 HFKH-ENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQMLSDDHIQYFIYQTL 122 + + NIIT+ +I + ++ E + D ++ Q L+D I++++Y+ L Sbjct: 87 NLRGGPNIITLADIVKDPVSRTPA---LVFEHVNNTDFKQLY--QTLTDYDIRFYMYEIL 141 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCD-LKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 +A+ H ++HRD+KP N++I+ L++ D+GLA N Sbjct: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR---------- 191 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRR-PIFPGRDYRHQLLLIFGIIG 240 VA+R+++ PE+++ Y ++D+WS GC+LA + R+ P F G D QL+ I ++G Sbjct: 192 -VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR-----VNPKGIDLLQRMLVFDPA 295 T + + + L + E+ V+P+ +D L ++L +D Sbjct: 251 TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQ 310 Query: 296 KRITAKEALEHPYL 309 R+TA+EA+EHPY Sbjct: 311 SRLTAREAMEHPYF 324 >1FOT-A nrPDB Length = 318 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 125/310 (40%), Gaps = 60/310 (19%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 DFQ+ LG G++G V + G A+K ++ + T E +L H Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTH 65 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVI-STQMLSDDHIQYFIYQTLRAVK 126 II ++ +F++ ++++I + ++ L ++ +Q + +++ + A++ Sbjct: 66 PFIIRMWG-----TFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALE 120 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH ++I+RDLKP N+L++ N +K+ DFG A+ + + T Sbjct: 121 YLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDV-------------TYTLCGTP 167 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APEV+ ++ Y++++D WS G ++ E+ F + I Sbjct: 168 DYIAPEVV-STKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILN--------- 217 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI-----TAK 301 + P N DLL R++ D ++R+ + Sbjct: 218 -----------------------AELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTE 254 Query: 302 EALEHPYLQT 311 + HP+ + Sbjct: 255 DVKNHPWFKE 264 >4CRL-A nrPDB Length = 406 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 99/358 (27%), Positives = 161/358 (44%), Gaps = 46/358 (12%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEI--VAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 +++ + G G YG V A K + A+K+IE ++ REI +L+ KH Sbjct: 24 EYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQIEGT---GISMSACREIALLRELKHP 79 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM----------LSDDHIQYFIY 119 N+I++ + +V+++ + + DL +I L ++ +Y Sbjct: 80 NVISLQKVFLS---HADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLY 136 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLIN----SNCDLKVCDFGLARIIDESAADNSEPTGQ 175 Q L + LH + V+HRDLKP+N+L+ +K+ D G AR+ + P Sbjct: 137 QILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFN-------SPLKP 189 Query: 176 QSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD-------- 227 + + V T WYRAPE++L + Y++A+D+W+ GCI AEL PIF R Sbjct: 190 LADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNP 249 Query: 228 -YRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPL------EKMFPRVNP 280 + QL IF ++G P + + P +K EK + + Sbjct: 250 YHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDS 309 Query: 281 KGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDP-NDEPEGEPIPPSFFEFDHYKEA 337 K LLQ++L DP KRIT+++A++ PY P +D G IP EF +E Sbjct: 310 KAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEP 367 >6E9W-A nrPDB Length = 443 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 66/356 (18%), Positives = 131/356 (36%), Gaps = 60/356 (16%) Query: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTL--REIK 61 R + + D+++ ++G GA+G V HK T ++ A+K + F+ + E Sbjct: 95 RDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERD 154 Query: 62 ILKHFKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDHIQYFIYQ 120 I+ ++ +F +F++ +Y++ E M DL ++S + + +++ + Sbjct: 155 IMAFANSPWVVQLF-----YAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAE 209 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 + A+ +H IHRD+KP N+L++ + LK+ DFG +++ + Sbjct: 210 VVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCD--------- 260 Query: 181 EYVATRWYRAPEVML---TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 V T Y +PEV+ Y R D WS G L E+ + F I Sbjct: 261 TAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMN 320 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 + +D ++ + +L+ L D R Sbjct: 321 HKNSLTFPDD----------------------------NDISKEAKNLICAFLT-DREVR 351 Query: 298 I---TAKEALEHPYLQ--TYHDPNDEPEGEPIPPSF------FEFDHYKEALTTKD 342 + +E H + + + P+ P FD +E ++ Sbjct: 352 LGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEE 407 >2PVN-A nrPDB Length = 352 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 86/321 (26%), Positives = 150/321 (46%), Gaps = 27/321 (8%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILK 64 + + D+++ +G G Y V + E K I KP+ + REIKIL+ Sbjct: 46 VQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKKKKIKREIKILQ 101 Query: 65 HF-KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLR 123 + NI+ + +I R + + +I E + +V+ L+D I+Y+IY+ L+ Sbjct: 102 NLCGGPNIVKLLDIVRDQHSKTPS---LIFEYVNNTDFKVL-YPTLTDYDIRYYIYELLK 157 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCD-LKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 A+ H ++HRD+KP N++I+ L++ D+GLA N Sbjct: 158 ALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVR----------- 206 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRR-PIFPGRDYRHQLLLIFGIIGT 241 VA+R+++ PE+++ Y ++D+WS GC+ A + R+ P F G D QL+ I ++GT Sbjct: 207 VASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGT 266 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR-----VNPKGIDLLQRMLVFDPAK 296 + L + + + P K V+P+ ID L ++L +D + Sbjct: 267 DGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQE 326 Query: 297 RITAKEALEHPYLQTYHDPND 317 R+TA EA+ HPY Q + Sbjct: 327 RLTALEAMTHPYFQQVRAAEN 347 >6ED6-A nrPDB Length = 415 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 69/352 (19%), Positives = 131/352 (37%), Gaps = 54/352 (15%) Query: 4 RIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTL--REIK 61 R + + D+ + ++G GA+G V HK + ++ A+K + F+ + E Sbjct: 81 RGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERD 140 Query: 62 ILKHFKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDHIQYFIYQ 120 I+ ++ +F +F++ +Y++ E M DL ++S + + +++ + Sbjct: 141 IMAFANSPWVVQLF-----YAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAE 195 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 + A+ +H +IHRD+KP N+L++ + LK+ DFG +DE+ Sbjct: 196 VVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGM---------VHCD 246 Query: 181 EYVATRWYRAPEVMLTSAK---YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 V T Y +PEV+ + Y R D WS G L E+ + F I Sbjct: 247 TAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMD 306 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 + D ++ +L+ L D R Sbjct: 307 HKNSLCFPED----------------------------AEISKHAKNLICAFLT-DREVR 337 Query: 298 I---TAKEALEHPYLQ--TYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLK 344 + +E +HP+ + +H N P+ P +D K Sbjct: 338 LGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDK 389 >2X4F-A nrPDB Length = 373 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 68/300 (22%), Positives = 119/300 (39%), Gaps = 51/300 (17%) Query: 17 SLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFN 76 +LG G +G V TG +A K I+ EI ++ H N+I ++ Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIK-TRGMKDKEEVKNEISVMNQLDHANLIQLY- 152 Query: 77 IQRPDSFENFNEVYIIQELMQTD--LHRVISTQM-LSDDHIQYFIYQTLRAVKVLHGSNV 133 D+FE+ N++ ++ E + R+I L++ F+ Q ++ +H + Sbjct: 153 ----DAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYI 208 Query: 134 IHRDLKPSNLL-INSNC-DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 +H DLKP N+L +N + +K+ DFGLAR + + T + AP Sbjct: 209 LHLDLKPENILCVNRDAKQIKIIDFGLARRYKP-----------REKLKVNFGTPEFLAP 257 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCI 251 EV+ S D+WS G I L F G + L I Sbjct: 258 EVV-NYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILAC------------- 303 Query: 252 ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQT 311 ++ F ++ + + + ++L+ + + RI+A EAL+HP+L Sbjct: 304 ---------------RWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSD 348 >6HXF-B nrPDB Length = 302 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 73/306 (23%), Positives = 124/306 (40%), Gaps = 52/306 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +++ LG+GA+G V A +K TG + A K IE + EI+IL H I+ Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIE-TKSEEELEDYIVEIEILATCDHPYIV 79 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS---TQMLSDDHIQYFIYQTLRAVKVLH 129 + ++ + +++I+ E I + L++ IQ Q L A+ LH Sbjct: 80 KLLG-----AYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLH 134 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 +IHRDLK N+L+ D+++ DFG++ ++ ++ T ++ Sbjct: 135 SKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDS----------FIGTPYWM 184 Query: 190 APEVM----LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 APEV+ + Y D+WS G L E+ P + LL I Sbjct: 185 APEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIA--------- 235 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 KS P P + + + D L+ L +P R +A + LE Sbjct: 236 ---------------KSDPPTLLTP-----SKWSVEFRDFLKIALDKNPETRPSAAQLLE 275 Query: 306 HPYLQT 311 HP++ + Sbjct: 276 HPFVSS 281 >2WO6-A nrPDB Length = 382 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 84/348 (24%), Positives = 155/348 (44%), Gaps = 62/348 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HE 69 +++ SL+G+G++G V A + E VAIK I+ +K F + E+++L+ H+ Sbjct: 54 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIK--NKKAFLNQAQIEVRLLELMNKHD 111 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST---QMLSDDHIQYFIYQTLRAVK 126 + + + F N + ++ E++ +L+ ++ + +S + + F Q A+ Sbjct: 112 TEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALL 171 Query: 127 VLH--GSNVIHRDLKPSNLLIN--SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 L ++IH DLKP N+L+ +K+ DFG + + + +Y Sbjct: 172 FLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIY-------------QY 218 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 + +R+YR+PEV+L Y A+D+WS GCIL E+ P+F G + Q+ I ++G P Sbjct: 219 IQSRFYRSPEVLLG-MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIP 277 Query: 243 HSDNDLRCIESPRAREYIKSLP--------------MYPAAPLEKMFPRVNPK------- 281 + ++P+AR++ + LP Y K+ + + Sbjct: 278 PAHI---LDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGR 334 Query: 282 --------------GIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDP 315 DL+ RML +DP RI AL+H + + D Sbjct: 335 RAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >5XVU-A nrPDB Length = 332 Score = 220 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 88/321 (27%), Positives = 151/321 (47%), Gaps = 29/321 (9%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILK 64 + +N + +++ +G G Y V + A KP+ + REIKIL+ Sbjct: 25 LQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA----IKVLKPVKKKKIKREIKILQ 80 Query: 65 HFKH-ENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQMLSDDHIQYFIYQTL 122 + NII + +I + + + +I E + D + +D I+Y+IYQ L Sbjct: 81 NLNGGPNIIKLLDIVKDPVTKTPS---LIFEYINNIDFKTLYPK--FTDKDIRYYIYQIL 135 Query: 123 RAVKVLHGSNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 +A+ H ++HRD+KP N++I+ N +++ +GLA N Sbjct: 136 KALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVR---------- 185 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRR-PIFPGRDYRHQLLLIFGIIG 240 VA+R+Y+ PE+++ Y ++D+WS GC+LA + ++ P F G D QL+ I ++G Sbjct: 186 -VASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLG 244 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVN-----PKGIDLLQRMLVFDPA 295 T L+ Y+ L Y P + N + IDL+ +ML++D A Sbjct: 245 TEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHA 304 Query: 296 KRITAKEALEHPYLQTYHDPN 316 KRI KEA+EHPY + + + Sbjct: 305 KRIAPKEAMEHPYFREVREES 325 >5KKR-C nrPDB Length = 395 Score = 220 bits (560), Expect = 8e-58, Method: Composition-based stats. Identities = 78/315 (24%), Positives = 136/315 (43%), Gaps = 33/315 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 DF+ S LG G GVV +HKP+G ++A K I KP + +RE+++L Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 127 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIST-QMLSDDHIQYFIYQTLRAVKVL 128 I+ + +F + E+ I E M L +V+ + + + ++ + L Sbjct: 128 IVGFYG-----AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 182 Query: 129 -HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 ++HRD+KPSN+L+NS ++K+CDFG++ + +S A+ +V TR Sbjct: 183 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN------------SFVGTRS 230 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH-QLLLIFGIIGTPHSDN 246 Y +PE + YS D+WS G L E+ + R P D + +L+ + G Sbjct: 231 YMSPERL-QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 289 Query: 247 DLRCIESPRAREY-IKSLPMYPAAPLEKMFPRVNP----------KGIDLLQRMLVFDPA 295 Y + S P L P + D + + L+ +PA Sbjct: 290 PRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPA 349 Query: 296 KRITAKEALEHPYLQ 310 +R K+ + H +++ Sbjct: 350 ERADLKQLMVHAFIK 364 >6HMD-A nrPDB Length = 365 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 88/325 (27%), Positives = 156/325 (48%), Gaps = 29/325 (8%) Query: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 + D+QL LG G Y V A + E + KP+ + RE+KIL++ Sbjct: 49 WGNQDDYQLVRKLGRGKYSEVFEAINITNNER----VVVKILKPVKKKKIKREVKILENL 104 Query: 67 KH-ENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQMLSDDHIQYFIYQTLRA 124 + NII + + + + ++ E + D ++ Q+L+D I++++Y+ L+A Sbjct: 105 RGGTNIIKLIDTVKDPVSKTPA---LVFEYINNTDFKQLY--QILTDFDIRFYMYELLKA 159 Query: 125 VKVLHGSNVIHRDLKPSNLLINS-NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 + H ++HRD+KP N++I+ L++ D+GLA + N V Sbjct: 160 LDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR-----------V 208 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRR-PIFPGRDYRHQLLLIFGIIGTP 242 A+R+++ PE+++ Y ++D+WS GC+LA + RR P F G+D QL+ I ++GT Sbjct: 209 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTE 268 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR-----VNPKGIDLLQRMLVFDPAKR 297 L+ + L + E V+P+ +DLL ++L +D +R Sbjct: 269 ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR 328 Query: 298 ITAKEALEHPYLQTYHDPNDEPEGE 322 +TAKEA+EHPY +P + Sbjct: 329 LTAKEAMEHPYFYPVVKEQSQPSAD 353 >2BRG-A nrPDB Length = 297 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 78/315 (24%), Positives = 130/315 (41%), Gaps = 47/315 (14%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 D+ L LGEGAYG V A ++ T E VA+K ++ +EI I K HEN Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHEN 66 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVKVL 128 ++ + +R + + Y+ E R+ + + Q F +Q + V L Sbjct: 67 VVKFYGHRREGNIQ-----YLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYL 121 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 HG + HRD+KP NLL++ +LK+ DFGLA + ++ + + T Y Sbjct: 122 HGIGITHRDIKPENLLLDERDNLKISDFGLATVF--------RYNNRERLLNKMCGTLPY 173 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 APE++ ++ +DVWSCG +L + + SD+ Sbjct: 174 VAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPW-----------------DQPSDSCQ 216 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPY 308 + + Y+ +APL LL ++LV +P+ RIT + + + Sbjct: 217 EYSDWKEKKTYLNPWKKIDSAPLA------------LLHKILVENPSARITIPDIKKDRW 264 Query: 309 LQTYHDPNDEPEGEP 323 Y+ P + P Sbjct: 265 ---YNKPLKKGAKRP 276 >3TXO-A nrPDB Length = 353 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 61/340 (17%), Positives = 128/340 (37%), Gaps = 61/340 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFK- 67 +F+ +LG+G++G V A K TG++ A+K ++ + T+ E +IL + Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H + +F F+ + ++ + E + + + ++ + +++ + + A+ Sbjct: 83 HPFLTQLFCC-----FQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 137 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 LH +I+RDLK N+L++ K+ DFG+ + E + T Sbjct: 138 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCK----------EGICNGVTTATFCGT 187 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Y APE++ Y A+D W+ G +L E+ F + I Sbjct: 188 PDYIAPEILQE-MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI---------- 236 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI-TAKE-- 302 + +YP ++ +L+ + +P R+ + + Sbjct: 237 --------------LNDEVVYPTW--------LHEDATGILKSFMTKNPTMRLGSLTQGG 274 Query: 303 ---ALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALT 339 L HP+ + + I P F +E ++ Sbjct: 275 EHAILRHPFFKEI--DWAQLNHRQIEPPFRPRIKSREDVS 312 >1KOB-A nrPDB Length = 387 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 78/340 (22%), Positives = 134/340 (39%), Gaps = 55/340 (16%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 + + + LG GA+GVV K TG + K I PL EI I+ H Sbjct: 49 VYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPY-PLDKYTVKNEISIMNQLHH 107 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVISTQ--MLSDDHIQYFIYQTLRAV 125 +I + D+FE+ E+ +I E + L I+ + +S+ + ++ Q + Sbjct: 108 PKLINLH-----DAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGL 162 Query: 126 KVLHGSNVIHRDLKPSNLLINSN--CDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 K +H +++H D+KP N++ + +K+ DFGLA ++ Sbjct: 163 KHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTT----------- 211 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 AT + APE ++ D+W+ G + L F G D Sbjct: 212 ATAEFAAPE-IVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGED---------------- 254 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 DL +++ + ++ E F V+P+ D ++ +L +P KR+T +A Sbjct: 255 ---DLETLQNVKRCDWEFD---------EDAFSSVSPEAKDFIKNLLQKEPRKRLTVHDA 302 Query: 304 LEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDL 343 LEHP+L+ H IP S + K D Sbjct: 303 LEHPWLKGDHSNLT----SRIPSSRYNKIRQKIKEKYADW 338 >3ORZ-A nrPDB Length = 316 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 68/311 (21%), Positives = 127/311 (40%), Gaps = 56/311 (18%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLREIKILKHFKH 68 DF+ +LGEG++ V A T AIK +E K RE ++ H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 + ++ F++ ++Y + L + + +++ + + A++ Sbjct: 97 PFFVKLY-----FCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALE 151 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LHG +IHRDLKP N+L+N + +++ DFG A+++ P +Q+ +V T Sbjct: 152 YLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVL--------SPESKQARANSFVGTA 203 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y +PE++ + ++ D+W+ GCI+ +L P F + I + Sbjct: 204 QYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL-------- 254 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE---- 302 EY + PK DL++++LV D KR+ +E Sbjct: 255 -----------EYDFPEKFF-------------PKARDLVEKLLVLDATKRLGCEEMEGY 290 Query: 303 --ALEHPYLQT 311 HP+ ++ Sbjct: 291 GPLKAHPFFES 301 >3EQC-A nrPDB Length = 360 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 138/315 (43%), Gaps = 33/315 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 DF+ S LG G GVV +HKP+G ++A K I KP + +RE+++L Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 92 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIST-QMLSDDHIQYFIYQTLRAVKVL 128 I+ + +F + E+ I E M L +V+ + + + ++ + L Sbjct: 93 IVGFYG-----AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 147 Query: 129 -HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 ++HRD+KPSN+L+NS ++K+CDFG++ + +S A+ +V TR Sbjct: 148 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN------------SFVGTRS 195 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y +PE + YS D+WS G L E+ + R P D + L+ + ++ Sbjct: 196 YMSPERL-QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 254 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNP------------KGIDLLQRMLVFDPA 295 R R P A E + VN + D + + L+ +PA Sbjct: 255 PRPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPA 314 Query: 296 KRITAKEALEHPYLQ 310 +R K+ + H +++ Sbjct: 315 ERADLKQLMVHAFIK 329 >4U41-A nrPDB Length = 332 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 72/349 (20%), Positives = 138/349 (39%), Gaps = 54/349 (15%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 + + + F+L ++G G YG V H TG++ AIK ++ + ++ EI +LK Sbjct: 19 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL--EINMLKK 76 Query: 66 F-KHENIITIFN-IQRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQYFIY 119 + H NI T + + + ++++++ E TDL + L +D I Y Sbjct: 77 YSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISR 136 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 + LR + LH +VIHRD+K N+L+ N ++K+ DFG++ +D + + Sbjct: 137 EILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRN--------- 187 Query: 180 TEYVATRWYRAPEVMLTSAK----YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLI 235 ++ T ++ APEV+ Y D+WSCG E+ P L LI Sbjct: 188 -TFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLI 246 Query: 236 FGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPA 295 P + + + ++ LV + Sbjct: 247 PR--NPPPRLKSKKWSKKFFSF----------------------------IEGCLVKNYM 276 Query: 296 KRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLK 344 +R + ++ L+HP+++ PN+ + + + + Sbjct: 277 QRPSTEQLLKHPFIRD--QPNERQVRIQLKDHIDRTRKKRGEKDETEYE 323 >6EII-A nrPDB Length = 352 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 86/313 (27%), Positives = 152/313 (48%), Gaps = 27/313 (8%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILK 64 + + D+QL LG G Y V A + E + KP+ + REIKIL+ Sbjct: 54 VEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK----VVVKILKPVKKKKIKREIKILE 109 Query: 65 HFKH-ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLR 123 + + NIIT+ +I + + + + + TD ++ Q L+D I++++Y+ L+ Sbjct: 110 NLRGGPNIITLADIVKDPV--SRTPALVFEHVNNTDFKQLY--QTLTDYDIRFYMYEILK 165 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCD-LKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 A+ H ++HRD+KP N++I+ L++ D+GLA N Sbjct: 166 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR----------- 214 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRR-PIFPGRDYRHQLLLIFGIIGT 241 VA+R+++ PE+++ Y ++D+WS GC+LA + R+ P F G D QL+ I ++GT Sbjct: 215 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGT 274 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR-----VNPKGIDLLQRMLVFDPAK 296 + + + L + E+ V+P+ +D L ++L +D Sbjct: 275 EDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS 334 Query: 297 RITAKEALEHPYL 309 R+TA+EA+EHPY Sbjct: 335 RLTAREAMEHPYF 347 >1U5R-A nrPDB Length = 348 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 72/344 (20%), Positives = 132/344 (38%), Gaps = 58/344 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFAL--RTLREIKILKHFKHEN 70 F +G G++G V A E+VAIKK+ K ++E++ L+ +H N Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI--STQMLSDDHIQYFIYQTLRAVKVL 128 I + + +++ E ++ + L + I + L+ + L Sbjct: 116 TIQYRGC-----YLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYL 170 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H N+IHRD+K N+L++ +K+ DFG A I+ + +V T ++ Sbjct: 171 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA--------------NSFVGTPYW 216 Query: 189 RAPEVML--TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 APEV+L +Y +DVWS G EL R+P + L I + N Sbjct: 217 MAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHI--------AQN 268 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 + ++S EY ++ + L P R T++ L+H Sbjct: 269 ESPALQSGHWSEYFRN----------------------FVDSCLQKIPQDRPTSEVLLKH 306 Query: 307 PYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNE 350 ++ P + + + L + +KK+++ E Sbjct: 307 RFVLRERPPT---VIMDLIQRTKDAVRELDNLQYRKMKKILFQE 347 >3LM0-A nrPDB Length = 327 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 81/309 (26%), Positives = 127/309 (41%), Gaps = 54/309 (17%) Query: 17 SLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDK-PLFALRTLREIKILKHFKH-ENIITI 74 LG G + VV K TG+ A K ++ + L EI +L+ K +I + Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 94 Query: 75 FNIQRPDSFENFNEVYIIQELMQTDLHRVIS----TQMLSDDHIQYFIYQTLRAVKVLHG 130 + +EN +E+ +I E + +M+S++ + I Q L V LH Sbjct: 95 HEV-----YENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQ 149 Query: 131 SNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 +N++H DLKP N+L++S D+K+ DFG++R I G + E + T Sbjct: 150 NNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKI-----------GHACELREIMGTPE 198 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APE +L + A D+W+ G I L F G D + L I + Sbjct: 199 YLAPE-ILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQV--------- 248 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 E+ F V+ D +Q +LV +P KR TA+ L H Sbjct: 249 -------------------NVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHS 289 Query: 308 YLQTYHDPN 316 +LQ + N Sbjct: 290 WLQQWDFEN 298 >3FXW-A nrPDB Length = 336 Score = 216 bits (551), Expect = 9e-57, Method: Composition-based stats. Identities = 81/354 (22%), Positives = 135/354 (38%), Gaps = 65/354 (18%) Query: 2 PKRIVYNISSDFQLKS-LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 P+ Y ++ D+QL +LG G G V H+ TG+ A+K + + + +E+ Sbjct: 19 PEPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL------YDSPKARQEV 72 Query: 61 KILKHFKH------ENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIST---QMLS 110 H +I+ I ++ + + II E M+ L I Q + Sbjct: 73 D-----HHWQASGGPHIVCILDV-YENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFT 126 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAA 167 + + A++ LH N+ HRD+KP NLL S + LK+ DFG A+ Sbjct: 127 EREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK------- 179 Query: 168 DNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 Q+ + T +Y APEV+ KY ++ D+WS G I+ L P F Sbjct: 180 -----ETTQNALQTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPF---- 229 Query: 228 YRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQ 287 Y + I R +Y P + V+ L++ Sbjct: 230 YSNTGQAIS-----------PGMKRRIRLGQYGFPNPE---------WSEVSEDAKQLIR 269 Query: 288 RMLVFDPAKRITAKEALEHPYLQTYHDPNDEP--EGEPIPPSFFEFDHYKEALT 339 +L DP +R+T + + HP++ P + +D KE +T Sbjct: 270 LLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMT 323 >4B8L-A nrPDB Length = 286 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 72/314 (22%), Positives = 124/314 (39%), Gaps = 56/314 (17%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLR 58 MPKR + I DF + LG+G +G V A K I+A+K + +K + R Sbjct: 7 MPKR-KFTI-DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRR 64 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQ-MLSDDHIQY 116 EI+I H +H NI+ ++N F + +Y++ E + +L++ + + Sbjct: 65 EIEIQSHLRHPNILRMYNY-----FHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSAT 119 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 F+ + A+ H VIHRD+KP NLL+ +LK+ DFG + Sbjct: 120 FMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWS------------VHAPS 167 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 T Y PE M+ + +D+W G + E + P F + I Sbjct: 168 LRRRTMCGTLDYLPPE-MIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIV 226 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAK 296 + K P ++ DL+ ++L + P + Sbjct: 227 NV--------------------------------DLKFPPFLSDGSKDLISKLLRYHPPQ 254 Query: 297 RITAKEALEHPYLQ 310 R+ K +EHP+++ Sbjct: 255 RLPLKGVMEHPWVK 268 >4CSV-A nrPDB Length = 275 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 112/300 (37%), Gaps = 53/300 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 S+ L+ LG G +G V + VA+K ++ + + L+E +I+K KH N Sbjct: 11 SEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLK--EGTMSVEEFLQEAQIMKKLKHPN 68 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIST---QMLSDDHIQYFIYQTLRAVK 126 ++ ++ + + +YII E M L + ++ + Q + Sbjct: 69 LVQLYGVCTKEP-----PIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMA 123 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L N IHRDL N L+ N +KV DFGLAR+I+E + Sbjct: 124 YLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAG--------AKFPIK 175 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSD 245 W APE + + ++S DVW+ G +L E+F + +PG + + Sbjct: 176 W-TAPEAI-SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVE--------- 224 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 R Y P + +L+ + P +R T E L Sbjct: 225 -----------RGYRMPRPQGCP-----------EEIYELMLQCWNKSPEERPTFAETLH 262 >2GCD-A nrPDB Length = 309 Score = 215 bits (549), Expect = 1e-56, Method: Composition-based stats. Identities = 72/344 (20%), Positives = 132/344 (38%), Gaps = 58/344 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFAL--RTLREIKILKHFKHEN 70 F +G G++G V A E+VAIKK+ K ++E++ L+ +H N Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI--STQMLSDDHIQYFIYQTLRAVKVL 128 I + + +++ E ++ + L + I + L+ + L Sbjct: 77 TIQYRGC-----YLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYL 131 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H N+IHRD+K N+L++ +K+ DFG A I+ + +V T ++ Sbjct: 132 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA--------------NSFVGTPYW 177 Query: 189 RAPEVML--TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 APEV+L +Y +DVWS G EL R+P + L I + N Sbjct: 178 MAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHI--------AQN 229 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 + ++S EY ++ + L P R T++ L+H Sbjct: 230 ESPALQSGHWSEYFRN----------------------FVDSCLQKIPQDRPTSEVLLKH 267 Query: 307 PYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNE 350 ++ P + + + L + +KK+++ E Sbjct: 268 RFVLRERPPT---VIMDLIQRTKDAVRELDNLQYRKMKKILFQE 308 >5X3F-B nrPDB Length = 393 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 73/357 (20%), Positives = 126/357 (35%), Gaps = 68/357 (19%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 F LG G++G V HK +G A+K ++ K TL E +IL+ Sbjct: 84 DQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 143 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 ++ + SF++ + +Y++ E + + S+ H +++ Q + + Sbjct: 144 PFLVKL-----EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 198 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH ++I+RDLKP NLLI+ ++V DFG A+ + T Sbjct: 199 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-------------GRTWTLCGTP 245 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APE++L+ Y++A+D W+ G ++ E+ P F I Sbjct: 246 EYLAPEIILSKG-YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS--------- 295 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI-----TAK 301 + + DLL+ +L D KR Sbjct: 296 -----------------------GKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVN 332 Query: 302 EALEHPYLQT------YHDPNDEP--EGEPIPPSFFEFDHYKEALTTKDLKKLIWNE 350 + H + T Y + P P FD Y+E + + E Sbjct: 333 DIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKE 389 >5LOH-A nrPDB Length = 341 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 66/324 (20%), Positives = 119/324 (36%), Gaps = 45/324 (13%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 +F + + GA+G V G++ A+K ++ D + E L K Sbjct: 36 EEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 93 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIS-TQMLSDDHIQYFIYQTLRAVK 126 I+ ++ S ++ N VY++ E + D+ ++ ++ +I + A+ Sbjct: 94 PFIVHLY-----YSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALD 148 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH +IHRDLKP N+LI++ +K+ DFGL+++ + + T Sbjct: 149 YLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKV----TLNRDINMMDILTTRTFCGTP 204 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APE++L A + A+D W+ G L E P F + I Sbjct: 205 DYLAPELLLGRA-HGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILK--------- 254 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 P + +++ ++ +L D KR KE H Sbjct: 255 --------------------RDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRH 294 Query: 307 PYLQTYHDPNDEPEGEPIPPSFFE 330 P N + + P P + Sbjct: 295 PLFSDVDWENLQHQTMPFIPQPDD 318 >4RA4-A nrPDB Length = 355 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 65/327 (19%), Positives = 126/327 (38%), Gaps = 58/327 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP--FDKPLFALRTLREIKILKHFKH 68 +DF +LG+G++G V A K T E+ AIK ++ + T+ E ++L Sbjct: 20 TDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDK 79 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 F Q F+ + +Y + E + ++ + + ++ + + Sbjct: 80 PP----FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 135 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH +I+RDLK N++++S +K+ DFG+ + E + T Sbjct: 136 FLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCK----------EHMMDGVTTRTFCGTP 185 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APE++ Y +++D W+ G +L E+ +P F G D I Sbjct: 186 DYIAPEII-AYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIM---------- 234 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA-----K 301 E+ S P ++ + + + + ++ PAKR+ + Sbjct: 235 -----------EHNVSYPK-----------SLSKEAVSICKGLMTKHPAKRLGCGPEGER 272 Query: 302 EALEHPYLQTYHDPNDEPEGEPIPPSF 328 + EH + + ++ E I P F Sbjct: 273 DVREHAFFR--RIDWEKLENREIQPPF 297 >4WNO-A nrPDB Length = 287 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 78/310 (25%), Positives = 130/310 (41%), Gaps = 58/310 (18%) Query: 12 DFQLKSLLGEGAYGVVCSATHKP-TGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +F K L+G GA+ VV H+ VA+K I + +EIKILK KHEN Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHEN 78 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIST-QMLSDDHIQYFIYQTLRAVKVL 128 I+ +++ Q E N VY++ E DL + + LS+D I+ F+ Q A+++L Sbjct: 79 IVALYDFQ-----EMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLL 133 Query: 129 HGSNVIHRDLKPSNLLIN---------SNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 H +IHRDLKP N+L++ ++ +K+ DFG AR + + Sbjct: 134 HSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAA---------- 183 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 + Y APEV++ S Y D+WS G I+ + + F + Sbjct: 184 -TLCGSPMYMAPEVIM-SQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDL-------- 233 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 + + + + ++P +APL ++ + + R+ Sbjct: 234 ----------RLFYEKNKTLVPTIPRETSAPLRQLLLALL-----------QRNHKDRMD 272 Query: 300 AKEALEHPYL 309 E HP+L Sbjct: 273 FDEFFHHPFL 282 >4WB7-A nrPDB Length = 405 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 74/357 (20%), Positives = 127/357 (35%), Gaps = 68/357 (19%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 F+ LG G++G V HK TG A+K ++ K TL E +IL+ Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 155 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 ++ + SF++ + +Y++ E + + S+ H +++ Q + + Sbjct: 156 PFLVKL-----EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 210 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH ++I+RDLKP NLLI+ ++V DFG A+ + T Sbjct: 211 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-------------GRTWTLCGTP 257 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APE++L+ Y++A+D W+ G ++ E+ P F I Sbjct: 258 EYLAPEIILSKG-YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS--------- 307 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI-----TAK 301 + + DLL+ +L D KR Sbjct: 308 -----------------------GKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVN 344 Query: 302 EALEHPYLQT------YHDPNDEP--EGEPIPPSFFEFDHYKEALTTKDLKKLIWNE 350 + H + T Y + P P FD Y+E + + E Sbjct: 345 DIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKE 401 >6CQF-A nrPDB Length = 297 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 73/309 (23%), Positives = 120/309 (38%), Gaps = 47/309 (15%) Query: 2 PKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIK 61 P + + L LG G YG V A K +G++VA+K ++ + +EI Sbjct: 7 PDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVS-TLQKEIL 65 Query: 62 ILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVIS-TQMLSDDHIQYFIY 119 ILK +H NI+ S+ +++I E L + T LS+ I Y Sbjct: 66 ILKTCRHANIVAYHG-----SYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCR 120 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 + L+ + LH IHRD+K +N+LIN ++++ DFG++ I + A Sbjct: 121 EVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARR---------- 170 Query: 180 TEYVATRWYRAPEV--MLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 ++ T ++ APEV + Y+ D+WS G EL +P L L+ Sbjct: 171 LAFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTK 230 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 P P K + + + ++ L P KR Sbjct: 231 SGYQP---------------------------PRLKEKGKWSAAFHNFIKVTLTKSPKKR 263 Query: 298 ITAKEALEH 306 +A + L H Sbjct: 264 PSATKMLSH 272 >6QAU-A nrPDB Length = 280 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 71/278 (25%), Positives = 119/278 (42%), Gaps = 29/278 (10%) Query: 12 DFQLKSLLGEGAYGVVCSATHKP-TGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 ++ + L+G GA+ VV H+ T VAIK I + + +EIKILK +HEN Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHEN 71 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-LSDDHIQYFIYQTLRAVKVL 128 I+ ++++Q E N V+++ E DL + + LS+D I+ F++Q A+++L Sbjct: 72 IVALYDVQ-----ELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRIL 126 Query: 129 HGSNVIHRDLKPSNLLIN---------SNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 H +IHRDLKP N+L++ S +K+ DFG AR + + Sbjct: 127 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAA---------- 176 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 + + Y APEV++ S Y D+WS G ++ + + +P F + + Sbjct: 177 -DLCGSPMYMAPEVIM-SQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNR 234 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR 277 S + E F Sbjct: 235 SLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSH 272 >5DYK-A nrPDB Length = 853 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 78/343 (22%), Positives = 133/343 (38%), Gaps = 60/343 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 + + + ++G G +G V HKPT A+K + E +I H Sbjct: 539 DELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDH 598 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIST-QMLSDDHIQYFIYQTLRAVK 126 II + +F++ Y + EL+ +L+ I +LS Q+++ + A++ Sbjct: 599 PFIIRLV-----RTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIE 653 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH N+++RDLKP N+L++ +K+ DFG A+ + Q V T Sbjct: 654 YLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKV-------------QGRAYTLVGTP 700 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APEV+L Y +D+W+ G L E F G D QL + I+ + Sbjct: 701 HYMAPEVILGKG-YGCTVDIWALGICLYEFICGPLPF-GNDEEDQLEIFRDILTGQLTFP 758 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA-----K 301 D + I+L++R+L P RI K Sbjct: 759 DYVT----------------------------DTDSINLMKRLLCRLPQGRIGCSINGFK 790 Query: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFEFDH-YKEALTTKDL 343 + +HP+ ++ D+ G + P Y E + K + Sbjct: 791 DIKDHPFFSNFN--WDKLAGRLLDPPLVSKSETYAEDIDIKQI 831 >5N23-A nrPDB Length = 352 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 74/357 (20%), Positives = 125/357 (35%), Gaps = 67/357 (18%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 F+ LG G++G V HK TG A+K ++ K TL E +I + Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNF 101 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 ++ + SF++ + +Y++ E + S+ H +++ Q + + Sbjct: 102 PFLVKL-----EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH ++I+RDLKP NLLI+ +KV DFG A+ + T Sbjct: 157 YLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTP------------WTLCGTP 204 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APE++L+ Y++A+D W+ G ++ E+ P F I Sbjct: 205 EYLAPEIILSKG-YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS--------- 254 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI-----TAK 301 + + DLL+ +L D KR Sbjct: 255 -----------------------GKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVN 291 Query: 302 EALEHPYLQT------YHDPNDEP--EGEPIPPSFFEFDHYKEALTTKDLKKLIWNE 350 + H + T Y + P P FD Y+E + + E Sbjct: 292 DIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKE 348 >3ALO-A nrPDB Length = 327 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 78/332 (23%), Positives = 138/332 (41%), Gaps = 55/332 (16%) Query: 2 PKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIK 61 P++ + D + +G GAYG V HKP+G+I+A+K+I + L ++ Sbjct: 13 PEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLD 72 Query: 62 I-LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS------TQMLSDDHI 114 + ++ I+ + + + +I ELM T + ++ ++ + Sbjct: 73 VVMRSSDCPYIVQFYGALFRE-----GDCWICMELMSTSFDKFYKYVYSVLDDVIPEEIL 127 Query: 115 QYFIYQTLRAVKVLHGS-NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPT 173 T++A+ L + +IHRD+KPSN+L++ + ++K+CDFG++ + +S A Sbjct: 128 GKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAK----- 182 Query: 174 GQQSGMTEYVATRWYRAPEVML---TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR- 229 T R Y APE + + Y DVWS G L EL R +P + Sbjct: 183 ------TRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVF 236 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 QL + +K P + E+ F +P I+ + Sbjct: 237 DQLTQV------------------------VKGDPPQLSNSEEREF---SPSFINFVNLC 269 Query: 290 LVFDPAKRITAKEALEHPYLQTYHDPNDEPEG 321 L D +KR KE L+HP++ Y + E Sbjct: 270 LTKDESKRPKYKELLKHPFILMYEERAVEVAC 301 >4AN9-A nrPDB Length = 301 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 131/303 (43%), Gaps = 51/303 (16%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 DF+ S LG G GVV +HKP+G ++A K I KP + +RE+++L Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 68 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIST-QMLSDDHIQYFIYQTLRAVKVL 128 I+ + +F + E+ I E M L +V+ + + + ++ + L Sbjct: 69 IVGFYG-----AFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 123 Query: 129 -HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 ++HRD+KPSN+L+NS ++K+CDFG++ + + A+ E+V TR Sbjct: 124 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMAN------------EFVGTRS 171 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y +PE + YS D+WS G L E+ + R P L I Sbjct: 172 YMSPERL-QGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVN---------- 220 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 + P P+A + + D + + L+ +PA+R K+ + H Sbjct: 221 -------------EPPPKLPSAVF-------SLEFQDFVNKCLIKNPAERADLKQLMVHA 260 Query: 308 YLQ 310 +++ Sbjct: 261 FIK 263 >3NYO-A nrPDB Length = 576 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 74/336 (22%), Positives = 139/336 (41%), Gaps = 61/336 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLF--ALRTLREIKILKHFKHEN 70 F+ +LG+G +G VC+ + TG++ A KK+E L E +IL+ Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVI---STQMLSDDHIQYFIYQTLRAVK 126 ++++ ++E + + ++ LM DL I + ++ + ++ Sbjct: 246 VVSL-----AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH +++RDLKP N+L++ + +++ D GLA + E V T Sbjct: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR-----------VGTV 349 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APEV+ + +Y+ + D W+ GC+L E+ + F Sbjct: 350 GYMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQ---------------------Q 387 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI-----TAK 301 + I+ +K +P E+ R +P+ L ++L DPA+R+ +A+ Sbjct: 388 RKKKIKREEVERLVKEVP-------EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAR 440 Query: 302 EALEHPYLQTYHD-----PNDEPEGEPIPPSFFEFD 332 E EHP + + EP +P P + + D Sbjct: 441 EVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKD 476 >5FET-A nrPDB Length = 847 Score = 210 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 82/344 (23%), Positives = 140/344 (40%), Gaps = 60/344 (17%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKHE 69 + + + ++G G +G V HKPT A+K + E +I H Sbjct: 534 ELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHP 593 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIST-QMLSDDHIQYFIYQTLRAVKV 127 II + +F++ N Y + EL+ +L+ I +LS Q+++ + A++ Sbjct: 594 FIIRLV-----RTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEY 648 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 LH N+++RDLKP N+L++ +K+ DFG A+ I Q V T Sbjct: 649 LHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKI-------------QGRAYTLVGTPH 695 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APEV+L Y +D+W+ G L E F G D QL + I+ Sbjct: 696 YMAPEVILGKG-YGCTVDIWALGVCLYEFICGPLPF-GNDQEDQLEIFRDIL-------- 745 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA-----KE 302 + P Y + + I+L++R+L P RI K+ Sbjct: 746 ----------TGQLTFPDYVS----------DQDSINLMKRLLCRLPQGRIGCSINGFKD 785 Query: 303 ALEHPYLQTYHDPNDEPEGEPI-PPSFFEFDHYKEALTTKDLKK 345 EH + ++ D+ G + PP + + Y E + K +++ Sbjct: 786 IKEHAFFGNFN--WDKLAGRLLEPPLVSKGETYAEDIDIKQIEE 827 >5MJB-A nrPDB Length = 305 Score = 210 bits (534), Expect = 8e-55, Method: Composition-based stats. Identities = 68/306 (22%), Positives = 116/306 (37%), Gaps = 34/306 (11%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHKPTGE---IVAIKKIEPFDKPLFA 53 P V + + +++ ++G G +G V K G+ VAIK ++ Sbjct: 12 PNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQR 71 Query: 54 LRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQT---DLHRVISTQMLS 110 L E I+ F H NII + + V II E M+ D + + Sbjct: 72 RDFLSEASIMGQFDHRNIIRLEGVVTKS-----RPVMIITEFMENCALDSFLRQNDGQFT 126 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 + + +K L N +HRDL N+L+NSN KV DFGL+R + + +D + Sbjct: 127 VIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPT 186 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYR 229 S + + RW APE + K++ A DVWS G ++ E+ + + Sbjct: 187 ----YTSSLGGKIPVRW-TAPEAI-AYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQ 240 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 + I P + + + K P + ++ L +M Sbjct: 241 DVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRF----------AEIVNTLDKM 290 Query: 290 LVFDPA 295 + +PA Sbjct: 291 I-RNPA 295 >5L6P-A nrPDB Length = 298 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 62/279 (22%), Positives = 110/279 (39%), Gaps = 23/279 (8%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHKPTGEI---VAIKKIEPFDKPLFA 53 P V + + +++ ++G G +G VC K G VAIK ++ Sbjct: 5 PNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQR 64 Query: 54 LRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQT---DLHRVISTQMLS 110 L E I+ F H NII + + V I+ E M+ D ++ + Sbjct: 65 RDFLSEASIMGQFDHPNIIRLEGVVTKS-----RPVMILTEFMENCALDSFLRLNDGQFT 119 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 + + +K L N +HRDL N+L+NSN KV DFGL+R +++ +D + Sbjct: 120 VIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPT 179 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYR 229 S + + RW APE + K++ A DVWS G ++ E+ + + Sbjct: 180 ----YTSSLGGKIPIRW-TAPEAI-AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQ 233 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPA 268 + + P + + +++ + P Sbjct: 234 DVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPK 272 >4LQP-A nrPDB Length = 508 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 80/413 (19%), Positives = 146/413 (35%), Gaps = 117/413 (28%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 DF ++G+GA+G V K TG+I A+K + + K E +L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 +++++ SF++ +Y+I E + + +I Q+ ++D ++++ + + A++ Sbjct: 162 PWVVSLY-----YSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIE 216 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADN---------------SE 171 +H IHR +KP N+LI+ +K+ DFGL+ ++ N S+ Sbjct: 217 TIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISK 276 Query: 172 PTGQQSGMTE------------------------------------YVATRWYRAPEVML 195 P + T+ V T Y APE+ L Sbjct: 277 PGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFL 336 Query: 196 TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPR 255 Y + D WS G I+ E + P F + I T +D+ Sbjct: 337 YQG-YGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDI------- 388 Query: 256 AREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI----TAKEALEHPYLQ- 310 ++ + DL++R+L +R+ A E HP+ + Sbjct: 389 ---------------------HISYEAEDLIRRLLTH-ADQRLGRHGGADEIKSHPFFRG 426 Query: 311 ----------------------TYHDPNDEPEGEPIPPSFFEFDHYKEALTTK 341 T P DE E P P+ + +E +T + Sbjct: 427 VDWNTIRQVEAPYIPKLSSITDTRFFPTDELENVPDSPAMAQAAKQREQMTKQ 479 >3VN9-A nrPDB Length = 340 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 79/310 (25%), Positives = 130/310 (41%), Gaps = 55/310 (17%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKI-LKHFKH 68 + D + LG GAYGVV H P+G+I+A+K+I R L ++ I ++ Sbjct: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST-----QMLSDDHIQYFIYQTLR 123 +T + + +V+I ELM T L + Q + +D + ++ Sbjct: 110 PFTVTFYGALFRE-----GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 Query: 124 AVKVLHGS-NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 A++ LH +VIHRD+KPSN+LIN+ +K+CDFG++ + +S A T Sbjct: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK-----------TID 213 Query: 183 VATRWYRAPEVM---LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 + Y APE + L YS D+WS G + EL + R + Sbjct: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY-------------DSW 260 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 GTP + + P PA + + +D + L + +R T Sbjct: 261 GTPFQQ---------LKQVVEEPSPQLPADKF-------SAEFVDFTSQCLKKNSKERPT 304 Query: 300 AKEALEHPYL 309 E ++HP+ Sbjct: 305 YPELMQHPFF 314 >1S9I-A nrPDB Length = 354 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 83/319 (26%), Positives = 136/319 (42%), Gaps = 37/319 (11%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 DF+ S LG G GVV H+P+G I+A K I KP + +RE+++L Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 75 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIST-QMLSDDHIQYFIYQTLRAVKVL 128 I+ + +F + E+ I E M L +V+ + + ++ + LR + L Sbjct: 76 IVGFYG-----AFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYL 130 Query: 129 -HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 ++HRD+KPSN+L+NS ++K+CDFG++ + +S A+ +V TR Sbjct: 131 REKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN------------SFVGTRS 178 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII-----GTP 242 Y APE + YS D+WS G L EL + R P D + + + G P Sbjct: 179 YMAPERL-QGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEP 237 Query: 243 HSDNDLRCIESPRAREY---------IKSLPMYPAAPLEKMFPR--VNPKGIDLLQRMLV 291 HS + + I L Y P P + + + L+ Sbjct: 238 HSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLI 297 Query: 292 FDPAKRITAKEALEHPYLQ 310 +PA+R K H +++ Sbjct: 298 KNPAERADLKMLTNHTFIK 316 >2WQN-A nrPDB Length = 310 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 71/307 (23%), Positives = 121/307 (39%), Gaps = 54/307 (17%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREI 60 + YN ++F+++ +G G + V A G VA+KK++ FD ++EI Sbjct: 24 PDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEI 83 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVIS-----TQMLSDDHI 114 +LK H N+I + SF NE+ I+ EL DL R+I +++ + + Sbjct: 84 DLLKQLNHPNVIKYY-----ASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTV 138 Query: 115 QYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTG 174 + Q A++ +H V+HRD+KP+N+ I + +K+ D GL R Sbjct: 139 WKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSL-- 196 Query: 175 QQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD-YRHQLL 233 V T +Y +PE + + Y+ D+WS GC+L E+ + F G + L Sbjct: 197 --------VGTPYYMSPERIHENG-YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLC 247 Query: 234 LIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFD 293 P +D + + L+ + D Sbjct: 248 KKIEQCDYPPLPSD-----------------------------HYSEELRQLVNMCINPD 278 Query: 294 PAKRITA 300 P KR Sbjct: 279 PEKRPDV 285 >6BDL-A nrPDB Length = 347 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 63/313 (20%), Positives = 124/313 (39%), Gaps = 57/313 (18%) Query: 11 SDFQLKSLLGEGAYGVVCSATHK-PTGEIVAIKKIEPF--DKPLFALRTLREIKILKHFK 67 SDF + LG G +G V K + A+K ++ E +I++ Sbjct: 34 SDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAH 93 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQE-LMQTDLHRVISTQM-LSDDHIQYFIYQTLRAV 125 + I+ ++ +F++ +Y++ E + +L ++ + D +++ + A Sbjct: 94 SDFIVRLY-----RTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAF 148 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 LH +I+RDLKP NL+++ K+ DFG A+ I G + T Sbjct: 149 AYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKI-----------GFGKKTWTFCGT 197 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Y APE++L + + D WS G ++ EL P F G D +I I Sbjct: 198 PEYVAPEIILNKG-HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGI------ 250 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI-----TA 300 IE P+ ++ +L++++ +P++R+ Sbjct: 251 ---DMIEFPK---------------------KIAKNAANLIKKLCRDNPSERLGNLKNGV 286 Query: 301 KEALEHPYLQTYH 313 K+ +H + + ++ Sbjct: 287 KDIQKHKWFEGFN 299 >3TKU-A nrPDB Length = 433 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 68/346 (19%), Positives = 131/346 (37%), Gaps = 60/346 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR--TLREIKILKHFKH 68 DF++ ++G GA+G V K T I A+K + ++ A E +L + Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQEL-MQTDLHRVIST--QMLSDDHIQYFIYQTLRAV 125 + I + +F++ N +Y++ + + DL ++S L +D +++I + + A+ Sbjct: 150 QWITALH-----YAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAI 204 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 +H + +HRD+KP N+L++ N +++ DFG +++ S V T Sbjct: 205 DSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVA---------VGT 255 Query: 186 RWYRAPEVML----TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 Y +PE++ KY D WS G + E+ F I Sbjct: 256 PDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN---- 311 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI--- 298 E P + V+ + DL+QR++ +R+ Sbjct: 312 ---------------HEERFQFPSHVT--------DVSEEAKDLIQRLICSR-ERRLGQN 347 Query: 299 TAKEALEHPYLQTYHDPNDEPEGEPI------PPSFFEFDHYKEAL 338 ++ +H + + + N P P FD + L Sbjct: 348 GIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVL 393 >4AF3-A nrPDB Length = 292 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 69/315 (21%), Positives = 120/315 (38%), Gaps = 54/315 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKH 68 DF++ LG+G +G V A K + IVA+K + +K + REI+I H H Sbjct: 23 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 82 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHR-VISTQMLSDDHIQYFIYQTLRAVK 126 NI+ ++N F + +Y+I E + +L++ + + + + + A+ Sbjct: 83 PNILRLYNY-----FYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 137 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 HG VIHRD+KP NLL+ +LK+ DFG + T Sbjct: 138 YCHGKKVIHRDIKPENLLLGLKGELKIADFGWS------------VHAPSLRRKTMCGTL 185 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y PE M+ ++ +D+W G + EL + P F + I + Sbjct: 186 DYLPPE-MIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV-------- 236 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 K V DL+ ++L +P++R+ + H Sbjct: 237 ------------------------DLKFPASVPTGAQDLISKLLRHNPSERLPLAQVSAH 272 Query: 307 PYLQTYHDPNDEPEG 321 P+++ P Sbjct: 273 PWVRANSRRVLPPSA 287 >4APC-A nrPDB Length = 350 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 62/300 (20%), Positives = 116/300 (38%), Gaps = 52/300 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHE 69 + +GEG++G G IK+I + RE+ +L + KH Sbjct: 24 EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHP 83 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQM---LSDDHIQYFIYQTLRAV 125 NI+ +SFE +YI+ + + DL + I+ Q +D I + Q A+ Sbjct: 84 NIVQY-----RESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLAL 138 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 K +H ++HRD+K N+ + + +++ DFG+AR+++ + + T Sbjct: 139 KHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARAC----------IGT 188 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 +Y +PE + + Y+ D+W+ GC+L EL + F ++ +L I P S Sbjct: 189 PYYLSPE-ICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSL 247 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 + L+ ++ +P R + LE Sbjct: 248 -------------------------------HYSYDLRSLVSQLFKRNPRDRPSVNSILE 276 >2J0K-A nrPDB Length = 656 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 116/311 (37%), Gaps = 55/311 (17%) Query: 1 MPKRIVYNIS-SDFQLKSLLGEGAYGVVCSATHKPTG---EIVAIKKIEPFDKPLFALRT 56 MP Y I +L +GEG +G V + VAIK + + Sbjct: 379 MPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKF 438 Query: 57 LREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQ 115 L+E ++ F H +I+ + + N V+II EL +L + + S D Sbjct: 439 LQEALTMRQFDHPHIVKLIGVITE------NPVWIIMELCTLGELRSFLQVRKFSLDLAS 492 Query: 116 Y--FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPT 173 + YQ A+ L +HRD+ N+L+++ +K+ DFGL+R +++S Sbjct: 493 LILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYY----- 547 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQL 232 + +W APE + +++ A DVW G + E+ + F G + Sbjct: 548 ---KASKGKLPIKW-MAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVI 602 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 I E + LPM P P P L+ + + Sbjct: 603 GRI----------------------ENGERLPMPPNCP---------PTLYSLMTKCWAY 631 Query: 293 DPAKRITAKEA 303 DP++R E Sbjct: 632 DPSRRPRFTEL 642 >1NY3-A nrPDB Length = 400 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 80/342 (23%), Positives = 138/342 (40%), Gaps = 54/342 (15%) Query: 9 ISSDFQLKS-LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKIL-KHF 66 I D+++ S +LG G G V +K T E A+K + + RE+++ + Sbjct: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRAS 112 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIST---QMLSDDHIQYFIYQTL 122 + +I+ I ++ + + + I+ E + L I Q ++ + Sbjct: 113 QCPHIVRIVDV-YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 A++ LH N+ HRD+KP NLL S N LK+ DFG A+ T + + Sbjct: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-----------TTSHNSL 220 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 T T +Y APEV+ KY ++ D+WS G I+ L P F Y + L I + Sbjct: 221 TTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPF----YSNHGLAISPGM 275 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 T R +Y P + V+ + L++ +L +P +R+T Sbjct: 276 KT-----------RIRMGQYEFPNPE---------WSEVSEEVKMLIRNLLKTEPTQRMT 315 Query: 300 AKEALEHPYLQTYHDPNDEP--EGEPIPPSFFEFDHYKEALT 339 E + HP++ P + ++ KE +T Sbjct: 316 ITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMT 357 >3KA0-A nrPDB Length = 320 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 81/342 (23%), Positives = 139/342 (40%), Gaps = 54/342 (15%) Query: 9 ISSDFQLKS-LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKIL-KHF 66 I D+++ S +LG G G V +K T E A+K + + RE+++ + Sbjct: 13 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRAS 66 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIST---QMLSDDHIQYFIYQTL 122 + +I+ I ++ + + + I+ E + L I Q ++ + Sbjct: 67 QCPHIVRIVDV-YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 125 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 A++ LH N+ HRD+KP NLL S N LK+ DFG A+ T + + Sbjct: 126 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-----------TTSHNSL 174 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 TE T +Y APEV+ KY ++ D+WS G I+ L P F Y + L I + Sbjct: 175 TEPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPF----YSNHGLAISPGM 229 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 T R +Y P + V+ + L++ +L +P +R+T Sbjct: 230 KT-----------RIRMGQYEFPNPE---------WSEVSEEVKMLIRNLLKTEPTQRMT 269 Query: 300 AKEALEHPYLQTYHDPNDEP--EGEPIPPSFFEFDHYKEALT 339 E + HP++ P + ++ KE +T Sbjct: 270 ITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMT 311 >4AW2-A nrPDB Length = 437 Score = 207 bits (527), Expect = 5e-54, Method: Composition-based stats. Identities = 57/312 (18%), Positives = 118/312 (37%), Gaps = 54/312 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR--TLREIKILKHFKH 68 DF++ ++G GA+G V K ++ A+K + ++ A E +L + Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDS 133 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQEL-MQTDLHRVIST--QMLSDDHIQYFIYQTLRAV 125 + I T+ +F++ N +Y++ + + DL ++S L ++ ++++ + + A+ Sbjct: 134 KWITTLH-----YAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAI 188 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 +H + +HRD+KP N+L++ N +++ DFG + E S V T Sbjct: 189 DSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVA---------VGT 239 Query: 186 RWYRAPEVML----TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 Y +PE++ +Y D WS G + E+ F I Sbjct: 240 PDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN---- 295 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI--- 298 V+ DL++R++ R+ Sbjct: 296 -----------------------HKERFQFPTQVTDVSENAKDLIRRLICSR-EHRLGQN 331 Query: 299 TAKEALEHPYLQ 310 ++ +HP+ Sbjct: 332 GIEDFKKHPFFS 343 >2VWV-A nrPDB Length = 302 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 71/306 (23%), Positives = 123/306 (40%), Gaps = 34/306 (11%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHKPTGEI---VAIKKIEPFDKPLFA 53 P V + + +++ ++G G +G VC K G+ VAIK ++ Sbjct: 2 PNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQR 61 Query: 54 LRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIS--TQMLS 110 L E I+ F+H NII + + N V I+ E M+ L + + Sbjct: 62 REFLSEASIMGQFEHPNIIRLEGVVT-----NSMPVMILTEFMENGALDSFLRLNDGQFT 116 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 + + ++ L + +HRDL N+L+NSN KV DFGL+R ++E+++D + Sbjct: 117 VIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPT 176 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYR 229 E S + + RW APE + K++ A D WS G ++ E+ + + Sbjct: 177 ET----SSLGGKIPIRW-TAPEAI-AFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQ 230 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 + I P + + + K P FP+V L +M Sbjct: 231 DVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPR------FPQVVSA----LDKM 280 Query: 290 LVFDPA 295 + +PA Sbjct: 281 I-RNPA 285 >3A8W-A nrPDB Length = 345 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 61/347 (17%), Positives = 129/347 (37%), Gaps = 55/347 (15%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLREIKILKHF-K 67 DF L ++G G+Y V K T I A+K ++ + E + + Sbjct: 9 QDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN 68 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAV 125 H ++ + F+ + ++ + E + + + + L ++H +++ + A+ Sbjct: 69 HPFLVGLH-----SCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLAL 123 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 LH +I+RDLK N+L++S +K+ D+G+ + E + + T Sbjct: 124 NYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCK----------EGLRPGDTTSTFCGT 173 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Y APE++ Y ++D W+ G ++ E+ R F I G P + Sbjct: 174 PNYIAPEILRGE-DYGFSVDWWALGVLMFEMMAGRSPFD----------IVGSSDNPDQN 222 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA----- 300 + + ++ ++ ++ K +L+ L DP +R+ Sbjct: 223 TEDYLFQVILEKQI-------------RIPRSLSVKAASVLKSFLNKDPKERLGCHPQTG 269 Query: 301 -KEALEHPYLQTYHDPNDEPEGEPIPPSF-----FEFDHYKEALTTK 341 + HP+ + E + P F D++ T + Sbjct: 270 FADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNE 316 >1ZXE-A nrPDB Length = 303 Score = 207 bits (526), Expect = 7e-54, Method: Composition-based stats. Identities = 74/323 (22%), Positives = 138/323 (42%), Gaps = 49/323 (15%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 +SDF+ ++LG+GA+G V A + AIKKI ++ L L E+ +L H+ Sbjct: 5 ASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLST--ILSEVMLLASLNHQ 62 Query: 70 NIITIFN--------IQRPDSFENFNEVYIIQELMQT-DLHRVISTQMLSDDHIQYF--I 118 ++ + ++ + + + ++I E + L+ +I ++ L+ +Y+ Sbjct: 63 YVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLF 122 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLA----RIIDESAADNSEPTG 174 Q L A+ +H +IHR+LKP N+ I+ + ++K+ DFGLA R +D D+ G Sbjct: 123 RQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPG 182 Query: 175 QQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLL 234 +T + T Y A EV+ + Y+ +D++S G I E+ P G + + L Sbjct: 183 SSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI--YPFSTGMERVNILKK 240 Query: 235 IFGI-IGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFD 293 + + I P +D + + ++ ++ D Sbjct: 241 LRSVSIEFPPDFDDNKMKVEKKI-----------------------------IRLLIDHD 271 Query: 294 PAKRITAKEALEHPYLQTYHDPN 316 P KR A+ L +L H Sbjct: 272 PNKRPGARTLLNSGWLPVKHQDE 294 >1JPA-A nrPDB Length = 312 Score = 207 bits (526), Expect = 7e-54, Method: Composition-based stats. Identities = 65/279 (23%), Positives = 110/279 (39%), Gaps = 23/279 (8%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHKPTGEI---VAIKKIEPFDKPLFA 53 P V + + +++ ++G G +G VCS K G+ VAIK ++ Sbjct: 19 PNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQR 78 Query: 54 LRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQ--MLS 110 L E I+ F H N+I + + + V II E M+ L + + Sbjct: 79 RDFLSEASIMGQFDHPNVIHLEGVVTKST-----PVMIITEFMENGSLDSFLRQNDGQFT 133 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 + + +K L N +HRDL N+L+NSN KV DFGL+R +++ +D + Sbjct: 134 VIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPT 193 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYR 229 S + + RW APE + K++ A DVWS G ++ E+ + + Sbjct: 194 ----YTSALGGKIPIRW-TAPEAI-QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQ 247 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPA 268 + I P + + + K P Sbjct: 248 DVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPK 286 >2OZA-A nrPDB Length = 356 Score = 207 bits (526), Expect = 7e-54, Method: Composition-based stats. Identities = 80/342 (23%), Positives = 138/342 (40%), Gaps = 54/342 (15%) Query: 9 ISSDFQLKS-LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKIL-KHF 66 I D+++ S +LG G G V +K T E A+K + + RE+++ + Sbjct: 15 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRAS 68 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIST---QMLSDDHIQYFIYQTL 122 + +I+ I ++ + + + I+ E + L I Q ++ + Sbjct: 69 QCPHIVRIVDV-YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 127 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 A++ LH N+ HRD+KP NLL S N LK+ DFG A+ T + + Sbjct: 128 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-----------TTSHNSL 176 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 T T +Y APEV+ KY ++ D+WS G I+ L P F Y + L I + Sbjct: 177 TTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPF----YSNHGLAISPGM 231 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 T R +Y P + V+ + L++ +L +P +R+T Sbjct: 232 KT-----------RIRMGQYEFPNPE---------WSEVSEEVKMLIRNLLKTEPTQRMT 271 Query: 300 AKEALEHPYLQTYHDPNDEP--EGEPIPPSFFEFDHYKEALT 339 E + HP++ P + ++ KE +T Sbjct: 272 ITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMT 313 >2X7G-A nrPDB Length = 389 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 81/372 (21%), Positives = 134/372 (36%), Gaps = 66/372 (17%) Query: 2 PKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIK 61 P +I + + + LG G + V VA+K ++ + L EIK Sbjct: 22 PVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQH--YTETALDEIK 79 Query: 62 ILKHFKH-----EN---IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI---STQMLS 110 +LK + N ++ + + + N V ++ E++ L + I + Q L Sbjct: 80 LLKCVRESDPSDPNKDMVVQLIDDFKISGM-NGIHVCMVFEVLGHHLLKWIIKSNYQGLP 138 Query: 111 DDHIQYFIYQTLRAVKVLHGS-NVIHRDLKPSNLLI------------------------ 145 ++ I Q L+ + LH +IH D+KP N+L+ Sbjct: 139 VRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPP 198 Query: 146 ----------NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVML 195 ++ + D A I AD TE + TR YR+ EV++ Sbjct: 199 PSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLI 258 Query: 196 TSAKYSRAMDVWSCGCILAELFLRRPIFP---GRDYRHQLLLIFGIIGTPHSDNDLRCIE 252 + YS D+WS C+ EL +F G DY I II S + Sbjct: 259 GAG-YSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALS 317 Query: 253 SPRAREYI------------KSLPMYPAAPLEKMFPRVN-PKGIDLLQRMLVFDPAKRIT 299 +RE+ K ++ + +P + + D L ML P KR + Sbjct: 318 GKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRAS 377 Query: 300 AKEALEHPYLQT 311 A E L HP+L + Sbjct: 378 AGECLRHPWLNS 389 >4EBW-A nrPDB Length = 304 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 113/300 (37%), Gaps = 54/300 (18%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTG---EIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 +L +GEG +G V + VAIK + + L+E ++ F Sbjct: 38 ERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFD 97 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQY--FIYQTLRA 124 H +I+ + + N V+II EL +L + + S D + YQ A Sbjct: 98 HPHIVKLIGVITE------NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTA 151 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 + L +HRD+ N+L++SN +K+ DFGL+R +++S + Sbjct: 152 LAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYY--------KASKGKLP 203 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPH 243 +W APE + +++ A DVW G + E+ + F G + I Sbjct: 204 IKW-MAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI-------- 253 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 E + LPM P P P L+ + +DP++R E Sbjct: 254 --------------ENGERLPMPPNCP---------PTLYSLMTKCWAYDPSRRPRFTEL 290 >3FME-A nrPDB Length = 290 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 77/310 (24%), Positives = 130/310 (41%), Gaps = 55/310 (17%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKI-LKHFKH 68 + D + LG GAYGVV H P+G+I+A+K+I R L ++ I ++ Sbjct: 6 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 65 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST-----QMLSDDHIQYFIYQTLR 123 +T + + +V+I ELM T L + Q + +D + ++ Sbjct: 66 PFTVTFYGALFRE-----GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 120 Query: 124 AVKVLHGS-NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 A++ LH +VIHRD+KPSN+LIN+ +K+CDFG++ + + A + + Sbjct: 121 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDID----------- 169 Query: 183 VATRWYRAPEVM---LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 + Y APE + L YS D+WS G + EL + R + Sbjct: 170 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY-------------DSW 216 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 GTP + + P PA + + +D + L + +R T Sbjct: 217 GTPFQQ---------LKQVVEEPSPQLPADKF-------SAEFVDFTSQCLKKNSKERPT 260 Query: 300 AKEALEHPYL 309 E ++HP+ Sbjct: 261 YPELMQHPFF 270 >6CCF-A nrPDB Length = 290 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 66/329 (20%), Positives = 133/329 (40%), Gaps = 71/329 (21%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE------------------------- 45 + ++L+S +G+GAYGVV A ++ A+K + Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 46 PFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVI 104 P + L R +EI ILK H N++ + + + + +Y++ +L++ + V Sbjct: 65 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPA---EDNLYLVFDLLRKGPVMEVP 121 Query: 105 STQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDE 164 + S++ + ++ + ++ LH ++HRD+KPSNLL+ + +K+ DFG++ + Sbjct: 122 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE- 180 Query: 165 SAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKY--SRAMDVWSCGCILAELFLRRPI 222 G + ++ T + APE + S + +A+DVW+ G L + Sbjct: 181 ---------GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 231 Query: 223 FPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKG 282 F + R+ ++P P ++ + Sbjct: 232 F------------------------IDDFILALHRKIKNEPVVFPEE------PEISEEL 261 Query: 283 IDLLQRMLVFDPAKRITAKEALEHPYLQT 311 DL+ +ML +P RI + HP++ Sbjct: 262 KDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >3PFQ-A nrPDB Length = 674 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 59/327 (18%), Positives = 126/327 (38%), Gaps = 58/327 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP--FDKPLFALRTLREIKILKHFKH 68 +DF +LG+G++G V + K T E+ A+K ++ + T+ E ++L Sbjct: 341 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 400 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 F Q F+ + +Y + E + ++ + + H ++ + + Sbjct: 401 PP----FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 456 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L +I+RDLK N++++S +K+ DFG+ + E + T Sbjct: 457 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK----------ENIWDGVTTKTFCGTP 506 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APE++ Y +++D W+ G +L E+ + F G D I Sbjct: 507 DYIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM---------- 555 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA-----K 301 E+ + P ++ + + + + ++ P KR+ + Sbjct: 556 -----------EHNVAYPK-----------SMSKEAVAICKGLMTKHPGKRLGCGPEGER 593 Query: 302 EALEHPYLQTYHDPNDEPEGEPIPPSF 328 + EH + + + ++ E + I P + Sbjct: 594 DIKEHAFFR--YIDWEKLERKEIQPPY 618 >6E2O-A nrPDB Length = 295 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 124/311 (39%), Gaps = 57/311 (18%) Query: 12 DFQLKS-----LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 D++ +LG+G YG+V + +AIK+I P ++ EI + KH Sbjct: 18 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEI-PERDSRYSQPLHEEIALHKHL 76 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQE-LMQTDLHRVISTQ----MLSDDHIQYFIYQT 121 KH+NI+ + F I E + L ++ ++ ++ I ++ Q Sbjct: 77 KHKNIVQYLGSFSENGFIK-----IFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQI 131 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINS-NCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 L +K LH + ++HRD+K N+LIN+ + LK+ DFG ++ + G Sbjct: 132 LEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRL----------AGINPCTE 181 Query: 181 EYVATRWYRAPEVMLTS-AKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 + T Y APE++ Y +A D+WS GC + E+ +P F Sbjct: 182 TFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPF---------------- 225 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 E A + ++P P ++ + + + DP KR Sbjct: 226 --------YELGEPQAAMFKVGMFKVHPEIPES-----MSAEAKAFILKCFEPDPDKRAC 272 Query: 300 AKEALEHPYLQ 310 A + L +L+ Sbjct: 273 ANDLLVDEFLK 283 >4OLI-A nrPDB Length = 645 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 71/307 (23%), Positives = 116/307 (37%), Gaps = 34/307 (11%) Query: 13 FQLKSLLGEGAYGVVCSATHKPT----GEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 + LGEG +G V + PT GE+VA+K ++ P +EI IL+ H Sbjct: 355 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYH 414 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 E+II + + ++ E + L + + + F Q + Sbjct: 415 EHIIKYKGCCED---QGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAY 471 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 LH + IHR+L N+L++++ +K+ DFGLA+ + E S W Sbjct: 472 LHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDS------PVFW 525 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APE + Y A DVWS G L EL + +IG + Sbjct: 526 Y-APECLKEYKFY-YASDVWSFGVTLYELLT-----HCDSSQSPPTKFLELIGI--AQGQ 576 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 + + E + LP P E L++ + + R T + + P Sbjct: 577 MTVLRLTELLERGERLPRPDKCPCEVY---------HLMKNCWETEASFRPTFENLI--P 625 Query: 308 YLQTYHD 314 L+T H+ Sbjct: 626 ILKTVHE 632 Score = 86.9 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 44/281 (15%), Positives = 84/281 (29%), Gaps = 49/281 (17%) Query: 30 ATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEV 89 + V +K ++P AL ++ H ++ + + E Sbjct: 88 GRDRGQELRVVLKVLDP-SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGP-----EN 141 Query: 90 YIIQELMQTD-LHRVISTQM--LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN 146 ++ E ++ L + + + Q A+ L N++H ++ N+L+ Sbjct: 142 IMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLA 201 Query: 147 SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAK-YSRAMD 205 + G + I S + E + + APE + A S AMD Sbjct: 202 RLGLAE----GTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMD 254 Query: 206 VWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPM 265 W G L E+ F G SP +E+ Sbjct: 255 KWGFGATLLEIC-----FDGE--------------------APLQSRSPSEKEHFYQRQH 289 Query: 266 YPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 P P+ L + L ++P +R + + L Sbjct: 290 RLPEP-------SCPQLATLTSQCLTYEPTQRPSFRTILRD 323 >6DBN-A nrPDB Length = 316 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 75/300 (25%), Positives = 119/300 (39%), Gaps = 34/300 (11%) Query: 13 FQLKSLLGEGAYGVVCSATHKP----TGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 + LGEG +G V + P TGE VA+K ++P +EI+IL++ H Sbjct: 37 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYH 96 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVI--STQMLSDDHIQYFIYQTLRAV 125 ENI+ I D N + +I E + L + + ++ + Q + + Sbjct: 97 ENIVKYKGICTEDG---GNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGM 153 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 L +HRDL N+L+ S +K+ DFGL + I+ + + S Sbjct: 154 DYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDS------PV 207 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 WY APE ++ S Y A DVWS G L EL + L +IG H Sbjct: 208 FWY-APECLMQSKFY-IASDVWSFGVTLHELLT-----YCDSDSSPMALFLKMIGPTHGQ 260 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 + + + K LP P P E L+++ F P+ R + + +E Sbjct: 261 MTVTRLVNTLKEG--KRLPCPPNCPDEVY---------QLMRKCWEFQPSNRTSFQNLIE 309 >4GS6-A nrPDB Length = 315 Score = 204 bits (518), Expect = 7e-53, Method: Composition-based stats. Identities = 84/330 (25%), Positives = 131/330 (39%), Gaps = 69/330 (20%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 + +++ ++G GA+GVVC A + + VAIK+IE + E++ L H N Sbjct: 9 KEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQIE---SESERKAFIVELRQLSRVNHPN 63 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD-----LHRVISTQMLSDDHIQYFIYQTLRAV 125 I+ ++ N V ++ E + LH + H + Q + V Sbjct: 64 IVKLYGACL-------NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 116 Query: 126 KVLHGSN---VIHRDLKPSNLLINSNCDL-KVCDFGLARIIDESAADNSEPTGQQSGMTE 181 LH +IHRDLKP NLL+ + + K+CDFG A I Q+ MT Sbjct: 117 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI-------------QTHMTN 163 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 + + APEV + YS DV+S G IL E+ RR F IG Sbjct: 164 NKGSAAWMAPEV-FEGSNYSEKCDVFSWGIILWEVITRRKPF-------------DEIGG 209 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 P + + + + IK+LP + L+ R DP++R + + Sbjct: 210 P-AFRIMWAVHNGTRPPLIKNLPKPIES---------------LMTRCWSKDPSQRPSME 253 Query: 302 E---ALEH--PYLQTYHDPNDEPEGEPIPP 326 E + H Y +P P +PP Sbjct: 254 EIVKIMTHLMRYFPGADEPLQYPCQHSLPP 283 >2H8H-A nrPDB Length = 535 Score = 203 bits (517), Expect = 8e-53, Method: Composition-based stats. Identities = 74/316 (23%), Positives = 127/316 (40%), Gaps = 58/316 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +L+ LG+G +G V T T VAIK ++P + L+E +++K +HE ++ Sbjct: 269 LRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGT--MSPEAFLQEAQVMKKLRHEKLV 325 Query: 73 TIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIST---QMLSDDHIQYFIYQTLRAVKVL 128 ++ + + +YI+ E M + L + + L + Q + + Sbjct: 326 QLYAVVSEE------PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 379 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 N +HRDL+ +N+L+ N KV DFGLAR+I+++ + +W Sbjct: 380 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG--------AKFPIKW- 430 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 APE L +++ DVWS G +L EL R +PG R L + Sbjct: 431 TAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE----------- 478 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 R Y P P DL+ + +P +R T + Sbjct: 479 ---------RGYRMPCP-----------PECPESLHDLMCQCWRKEPEERPTFEYLQA-- 516 Query: 308 YLQTYHDPNDEPEGEP 323 +L+ Y + EP+ +P Sbjct: 517 FLEDYFT-STEPQYQP 531 >2I0E-A nrPDB Length = 353 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 59/327 (18%), Positives = 126/327 (38%), Gaps = 58/327 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP--FDKPLFALRTLREIKILKHFKH 68 +DF +LG+G++G V + K T E+ A+K ++ + T+ E ++L Sbjct: 20 TDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGK 79 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 F Q F+ + +Y + E + ++ + + H ++ + + Sbjct: 80 PP----FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 135 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L +I+RDLK N++++S +K+ DFG+ + E + T Sbjct: 136 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK----------ENIWDGVTTKTFCGTP 185 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APE++ Y +++D W+ G +L E+ + F G D I Sbjct: 186 DYIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM---------- 234 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA-----K 301 E+ + P ++ + + + + ++ P KR+ + Sbjct: 235 -----------EHNVAYPK-----------SMSKEAVAICKGLMTKHPGKRLGCGPEGER 272 Query: 302 EALEHPYLQTYHDPNDEPEGEPIPPSF 328 + EH + + + ++ E + I P + Sbjct: 273 DIKEHAFFR--YIDWEKLERKEIQPPY 297 >6F3F-A nrPDB Length = 455 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 74/316 (23%), Positives = 126/316 (39%), Gaps = 58/316 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +L+ LG+G +G V T T VAIK ++P + L+E +++K +HE ++ Sbjct: 189 LRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGT--MSPEAFLQEAQVMKKLRHEKLV 245 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVIST---QMLSDDHIQYFIYQTLRAVKVL 128 ++ + + +YI+ E M L + + L + Q + + Sbjct: 246 QLYAVVSEE------PIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYV 299 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 N +HRDL+ +N+L+ N KV DFGLAR+I+++ + +W Sbjct: 300 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG--------AKFPIKW- 350 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 APE L +++ DVWS G +L EL R +PG R L + Sbjct: 351 TAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE----------- 398 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 R Y P P DL+ + +P +R T + Sbjct: 399 ---------RGYRMPCP-----------PECPESLHDLMCQCWRKEPEERPTFEYLQA-- 436 Query: 308 YLQTYHDPNDEPEGEP 323 +L+ Y + EP+ +P Sbjct: 437 FLEDYFT-STEPQYQP 451 >3DKO-A nrPDB Length = 318 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 63/279 (22%), Positives = 108/279 (38%), Gaps = 25/279 (8%) Query: 2 PKRIVYNISSD-----FQLKSLLGEGAYGVVCSATHKPTGEI---VAIKKIEPFDKPLFA 53 P R V+ + + +++ ++G G +G VCS K G+ VAIK ++ Sbjct: 29 PNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQR 88 Query: 54 LRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVISTQ--MLS 110 L E I+ F H N++ + + V I+ E M+ L + + Sbjct: 89 RDFLCEASIMGQFDHPNVVHLEGVVTRG-----KPVMIVIEFMENGALDAFLRKHDGQFT 143 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 + + ++ L +HRDL N+L+NSN KV DFGL+R+I++ Sbjct: 144 VIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVY 203 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYR 229 TG + RW APE + K++ A DVWS G ++ E+ + + Sbjct: 204 TTTG------GKIPVRW-TAPEAI-QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQ 255 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPA 268 + I P + + + K P Sbjct: 256 DVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPK 294 >6DBM-A nrPDB Length = 318 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 115/307 (37%), Gaps = 34/307 (11%) Query: 13 FQLKSLLGEGAYGVVCSATHKPT----GEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 + LGEG +G V + PT GE+VA+K ++ P +EI IL+ H Sbjct: 33 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYH 92 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 E+II + ++ E + L + + + F Q + Sbjct: 93 EHIIKYKGCCEDAGAASLQ---LVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAY 149 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 LH + IHRDL N+L++++ +K+ DFGLA+ + E S W Sbjct: 150 LHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDS------PVFW 203 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APE + Y A DVWS G L EL + +IG + Sbjct: 204 Y-APECLKEYKFY-YASDVWSFGVTLYELLT-----HCDSSQSPPTKFLELIGI--AQGQ 254 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 + + E + LP P E L++ + + R T + + P Sbjct: 255 MTVLRLTELLERGERLPRPDKCPAEVY---------HLMKNCWETEASFRPTFENLI--P 303 Query: 308 YLQTYHD 314 L+T H+ Sbjct: 304 ILKTVHE 310 >4TNB-A nrPDB Length = 590 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 70/343 (20%), Positives = 133/343 (38%), Gaps = 57/343 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLREIKILKHFKHEN 70 F+ +LG+G +G VC+ + TG++ A K++E K L E +IL+ + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVI---STQMLSDDHIQYFIYQTLRAVK 126 ++ + ++E + + ++ +M DL I ++ ++ + L ++ Sbjct: 246 VVNL-----AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH N ++RDLKP N+L++ +++ D GLA I E V T Sbjct: 301 DLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR-----------VGTV 349 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APEV+ + +Y + D W GC++ E+ + F GR + + Sbjct: 350 GYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEK-----------VKREEV 397 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT-----AK 301 D R +E+ + + + + + +L D +R+ A Sbjct: 398 DRRVLETEEVYSHKF-----------------SEEAKSICKMLLTKDAKQRLGCQEEEAA 440 Query: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHY-KEALTTKDL 343 E HP+ + + E P Y K+ L + Sbjct: 441 EVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQF 483 >2Y6O-A nrPDB Length = 291 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 62/266 (23%), Positives = 104/266 (39%), Gaps = 20/266 (7%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEI---VAIKKIEPFDKPLFALRTLREIKILKHF 66 +S +++ ++G G +G VCS K G+ VAIK ++ L E I+ F Sbjct: 13 ASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQF 72 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQ--MLSDDHIQYFIYQTLR 123 H NII + + V II E M+ L + + + + Sbjct: 73 DHPNIIHLEGVVTK-----CKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGS 127 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 +K L + +HRDL N+L+NSN KV DFG++R++++ G + Sbjct: 128 GMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRG------GKI 181 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTP 242 RW APE + K++ A DVWS G ++ E+ + + + I P Sbjct: 182 PIRW-TAPEAI-AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP 239 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPA 268 + + + K P Sbjct: 240 PPMDCPIALHQLMLDCWQKERSDRPK 265 >4OTD-A nrPDB Length = 341 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 72/329 (21%), Positives = 133/329 (40%), Gaps = 61/329 (18%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHF-- 66 DF+ ++LG G +G V + +P+GE+ AIK ++ D + E +IL Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 67 -KHENIITIFNIQRPDSFENFNEVYIIQEL-MQTDLHRVISTQMLSDDHIQYFIYQTLRA 124 H ++ +F F+ V + E DL I + + S+ ++ + Sbjct: 72 AGHPFLVNLFGC-----FQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLG 126 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 ++ LH +++RDLK NLL+++ +K+ DFGL + E G + + Sbjct: 127 LQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCK----------EGMGYGDRTSTFCG 176 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 T + APEV+ T Y+RA+D W G +L E+ + FPG D I Sbjct: 177 TPEFLAPEVL-TDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN------- 228 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI-----T 299 + ++ + I +++R+L +P +R+ Sbjct: 229 -------------------------DEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERD 263 Query: 300 AKEALEHPYLQTYHDPNDEPEGEPIPPSF 328 A++ + P+ +T + +PP F Sbjct: 264 AEDVKKQPFFRTLG--WEALLARRLPPPF 290 >6BXI-A nrPDB Length = 333 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 73/349 (20%), Positives = 135/349 (38%), Gaps = 71/349 (20%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 DF+ ++G GA+G V K TG + A+K + D + E IL Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 65 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYFIYQTLRAVK 126 ++ +F SF++ +Y+I E + + ++ L+++ Q++I +T+ A+ Sbjct: 66 LWVVKMF-----YSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAID 120 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY---- 182 +H IHRD+KP NLL++S +K+ DFGL + ++ S +++ Sbjct: 121 SIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 180 Query: 183 ---------------------VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRP 221 V T Y APEV + + Y++ D WS G I+ E+ + P Sbjct: 181 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-YNKLCDWWSLGVIMYEMLIGYP 239 Query: 222 IFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPK 281 F + + + ++L P P ++ K Sbjct: 240 PFCSETPQETY---------------------KKVMNWKETLTFPPEVP-------ISEK 271 Query: 282 GIDLLQR-MLVFDPAKRITA---KEALEHPYLQ--TYHDPNDEPEGEPI 324 DL+ R ++ RI A +E + + + + + P I Sbjct: 272 AKDLILRFCCEWEH--RIGAPGVEEIKSNSFFEGVDWEHIRERPAAISI 318 >4P5Q-A nrPDB Length = 361 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 60/266 (22%), Positives = 101/266 (37%), Gaps = 20/266 (7%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEI---VAIKKIEPFDKPLFALRTLREIKILKHF 66 +++ + ++G G +G VCS K + VAIK ++ L E I+ F Sbjct: 32 ATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQF 91 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQ--MLSDDHIQYFIYQTLR 123 H NII + + V I+ E M+ L + + + + Sbjct: 92 DHPNIIRLEGVVTKS-----KPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIAS 146 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 +K L +HRDL N+LINSN KV DFGL+R++++ G + Sbjct: 147 GMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG------GKI 200 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTP 242 RW +PE + K++ A DVWS G +L E+ + + + + P Sbjct: 201 PIRW-TSPEAI-AYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLP 258 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPA 268 + + + K P Sbjct: 259 PPMDCPAALYQLMLDCWQKDRNNRPK 284 >2R2P-A nrPDB Length = 295 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 67/306 (21%), Positives = 118/306 (38%), Gaps = 36/306 (11%) Query: 2 PKRIVYNISSDFQ-----LKSLLGEGAYGVVCSATHKPTGEI---VAIKKIEPFDKPLFA 53 P + V+ + + + ++ ++G G +G VCS K G+ VAIK ++ Sbjct: 8 PNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQR 67 Query: 54 LRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQ--MLS 110 L E I+ F H NII + + V I+ E M+ L + + Sbjct: 68 RDFLGEASIMGQFDHPNIIHLEGVVTKS-----KPVMIVTEYMENGSLDTFLKKNDGQFT 122 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 + + +K L +HRDL N+LINSN KV DFGL+R++++ Sbjct: 123 VIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 182 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYR 229 G + RW APE + K++ A DVWS G ++ E+ + + Sbjct: 183 TTRG------GKIPIRW-TAPEAI-AFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQ 234 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 + + P + + + K P + +++L + Sbjct: 235 DVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFD----------EIVNMLDK- 283 Query: 290 LVFDPA 295 L+ +PA Sbjct: 284 LIRNPA 289 >2FO0-A nrPDB Length = 495 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 113/298 (37%), Gaps = 53/298 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +D +K LG G YG V K VA+K ++ + + L+E ++K KH N Sbjct: 217 TDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK--EDTMEVEEFLKEAAVMKEIKHPN 274 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVIS---TQMLSDDHIQYFIYQTLRAVK 126 ++ + + + YII E M +L + Q ++ + Y Q A++ Sbjct: 275 LVQLLGVCTREP-----PFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 329 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L N IHR+L N L+ N +KV DFGL+R++ + + Sbjct: 330 YLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYT--------AHAGAKFPIK 381 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSD 245 W APE + K+S DVW+ G +L E+ +PG D L+ Sbjct: 382 W-TAPESL-AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE--------- 430 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 ++Y P K +L++ ++P+ R + E Sbjct: 431 -----------KDYRMERPEGCP-----------EKVYELMRACWQWNPSDRPSFAEI 466 >4XEY-B nrPDB Length = 408 Score = 200 bits (509), Expect = 8e-52, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 113/298 (37%), Gaps = 53/298 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +D +K LG G YG V K VA+K ++ + + L+E ++K KH N Sbjct: 125 TDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK--EDTMEVEEFLKEAAVMKEIKHPN 182 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVIS---TQMLSDDHIQYFIYQTLRAVK 126 ++ + + + YII E M +L + Q ++ + Y Q A++ Sbjct: 183 LVQLLGVCTREP-----PFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 237 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L N IHRDL N L+ N +KV DFGL+R++ + + Sbjct: 238 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYT--------AHAGAKFPIK 289 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSD 245 W APE + K+S DVW+ G +L E+ +PG D L+ Sbjct: 290 W-TAPESL-AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE--------- 338 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 ++Y P K +L++ ++P+ R + E Sbjct: 339 -----------KDYRMERPEGCP-----------EKVYELMRACWQWNPSDRPSFAEI 374 >4E20-A nrPDB Length = 290 Score = 200 bits (509), Expect = 8e-52, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 110/296 (37%), Gaps = 32/296 (10%) Query: 13 FQLKSLLGEGAYGVVCSATHKPT----GEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 + LGEG +G V + PT GE+VA+K ++ P REI+IL+ H Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYH 69 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 E+I+ ++ ++ E + L + + + F Q + Sbjct: 70 EHIVKYKGCCEDQGEKSVQ---LVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAY 126 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 LH + IHR L N+L++++ +K+ DFGLA+ + E S W Sbjct: 127 LHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDS------PVFW 180 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 Y APE + Y A DVWS G L EL + +IG H+ Sbjct: 181 Y-APECLKECKFY-YASDVWSFGVTLYELLT-----YCDSNQSPHTKFTELIG--HTQGQ 231 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 + + E + LP P E L++ + + R T + Sbjct: 232 MTVLRLTELLERGERLPRPDRCPCEIY---------HLMKNCWETEASFRPTFQNL 278 >6GQK-A nrPDB Length = 328 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 75/334 (22%), Positives = 120/334 (35%), Gaps = 72/334 (21%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHK-----PTGEIVAIKKIEPFDKPL 51 P ++ Y+ +F LG GA+G V AT + VA+K ++P Sbjct: 27 PTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHST 86 Query: 52 FALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-- 108 + E+K+L + HENI+ + + I + DL + + Sbjct: 87 EREALMSELKVLSYLGNHENIVNLLGACTHGG----PTLVITEYCCYGDLLNFLRRKRDE 142 Query: 109 ---------------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKV 153 L+ +H+ F YQ + + L N IHRDL N+L+ K+ Sbjct: 143 FVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKI 202 Query: 154 CDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCIL 213 CDFGLAR I + + + + +W APE + S Y+ DVWS G L Sbjct: 203 CDFGLARDIKNDSNYVDKGNAR-------LPVKW-MAPESIFNSV-YTFESDVWSYGIFL 253 Query: 214 AELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLE 272 ELF +PG + + + S P Y Sbjct: 254 WELFSLGSSPYPGMPVDSKFYKMIK-------------------EGFRMSSPEY------ 288 Query: 273 KMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 + D+++ DP KR T K+ ++ Sbjct: 289 -----APAEMYDIMKTCWDADPDKRPTFKQIVQD 317 >4FR4-A nrPDB Length = 384 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 57/310 (18%), Positives = 131/310 (42%), Gaps = 52/310 (16%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 F++ +G+G++G VC T ++ A+K + + +E++I++ +H Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 74 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-LSDDHIQYFIYQTLRAVK 126 ++ ++ SF++ +++++ +L+ DL + + ++ ++ FI + + A+ Sbjct: 75 PFLVNLW-----YSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALD 129 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L +IHRD+KP N+L++ + + + DF +A ++ +++ +T T+ Sbjct: 130 YLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAML-----------PRETQITTMAGTK 178 Query: 187 WYRAPEVMLTSAK--YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 Y APE+ + YS A+D WS G EL R + Sbjct: 179 PYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYH-------------------- 218 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT-AKEA 303 R+ K + + + + + LL+++L +P +R + + Sbjct: 219 ---------IRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDV 269 Query: 304 LEHPYLQTYH 313 PY+ + Sbjct: 270 QNFPYMNDIN 279 >4WUA-A nrPDB Length = 401 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 73/365 (20%), Positives = 131/365 (35%), Gaps = 68/365 (18%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH-- 68 + + LG G + V + + VA+K ++ + + L EI++LK ++ Sbjct: 41 GRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEH--YTETALDEIRLLKSVRNSD 98 Query: 69 EN------IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI---STQMLSDDHIQYFIY 119 N ++ + + + N + ++ E++ L + I + Q L ++ I Sbjct: 99 PNDPNREMVVQLLDDFKISGV-NGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQ 157 Query: 120 QTLRAVKVLHGS-NVIHRDLKPSNLLINSNCD---------------------------- 150 Q L+ + LH +IH D+KP N+L++ N Sbjct: 158 QVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTA 217 Query: 151 -LKVCDF-------GLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSR 202 +F A + AD TE + TR YR+ EV++ S Y+ Sbjct: 218 PATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSG-YNT 276 Query: 203 AMDVWSCGCILAELFLRRPIFPGRD------YRHQLLLIFGIIG---------TPHSDND 247 D+WS C+ EL +F + LI ++G +S Sbjct: 277 PADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEF 336 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFDPAKRITAKEALEH 306 + +K ++ + + + G D L ML P KR TA E L H Sbjct: 337 FTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRH 396 Query: 307 PYLQT 311 P+L + Sbjct: 397 PWLNS 401 >4E93-A nrPDB Length = 377 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 66/295 (22%), Positives = 111/295 (37%), Gaps = 51/295 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 D L +G G +G V S + +VA+K P + L+E +ILK + H N Sbjct: 114 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPN 173 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQ--MLSDDHIQYFIYQTLRAVKV 127 I+ + + +YI+ EL+ D + T+ L + + ++ Sbjct: 174 IVRLIGVCTQ-----KQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEY 228 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 L IHRDL N L+ LK+ DFG++R + ++ SG V +W Sbjct: 229 LESKCCIHRDLAARNCLVTEKNVLKISDFGMSR-------EEADGVYAASGGLRQVPVKW 281 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 APE + +YS DVWS G +L E F +P + Sbjct: 282 -TAPEAL-NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQT--------------- 324 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKG-IDLLQRMLVFDPAKRITA 300 RE+++ P P + P L+++ ++P +R + Sbjct: 325 ----------REFVEKGGRLP-------CPELCPDAVFRLMEQCWAYEPGQRPSF 362 >4M7I-A nrPDB Length = 299 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 70/269 (26%), Positives = 117/269 (43%), Gaps = 18/269 (6%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +DF+ LG G +GVV A +K AIK+I ++ L + +RE+K L +H Sbjct: 5 TDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 64 Query: 71 IITIFNIQRPDSFEN-------FNEVYIIQELMQT-DLHRVISTQMLSDDHIQ----YFI 118 I+ FN + +YI +L + +L ++ + ++ + + Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS--EPTGQQ 176 Q AV+ LH ++HRDLKPSN+ + +KV DFGL +D+ + + P Sbjct: 125 LQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAY 184 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 + T V T+ Y +PE + YS +D++S G IL EL F + R + L Sbjct: 185 ARHTGQVGTKLYMSPEQI-HGNSYSHKVDIFSLGLILFELL---YPFSTQMERVRTLTDV 240 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPM 265 + P E ++ + PM Sbjct: 241 RNLKFPPLFTQKYPCEYVMVQDMLSPSPM 269 >3PPZ-A nrPDB Length = 309 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 125/320 (39%), Gaps = 60/320 (18%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHEN 70 D +K +G G++G V A G VA+K + D LRE+ I+K +H N Sbjct: 38 DLNIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPN 95 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIS----TQMLSDDHIQYFIYQTLRAV 125 I+ + I+ E + + L+R++ + L + Y + + Sbjct: 96 IVLFMGAVTQPP-----NLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGM 150 Query: 126 KVLHGSN--VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 LH N ++HRDLK NLL++ +KVCDFGL+R+ + + Sbjct: 151 NYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSA----------A 200 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 T + APEV+ + DV+S G IL EL + + G Q++ G Sbjct: 201 GTPEWMAPEVLRDEPS-NEKSDVYSFGVILWELATLQQPW-GNLNPAQVVAAVGF----- 253 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI---TA 300 + +E PR +NP+ +++ +P KR T Sbjct: 254 ---KCKRLEIPR---------------------NLNPQVAAIIEGCWTNEPWKRPSFATI 289 Query: 301 KEALEHPYLQTYHDPNDEPE 320 + L P +++ P + + Sbjct: 290 MDLLR-PLIKSAVPPPNRSD 308 >5SYS-A nrPDB Length = 286 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 75/316 (23%), Positives = 127/316 (40%), Gaps = 58/316 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +L+ LG+G +G T T VAIK ++P + L+E +++K +HE ++ Sbjct: 20 LRLEVKLGQGCFGECWMGTWNGTTR-VAIKTLKPGT--MSPEAFLQEAQVMKKLRHEKLV 76 Query: 73 TIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM---LSDDHIQYFIYQTLRAVKVL 128 ++ + + +YI+ E M + L + +M L + Q + + Sbjct: 77 QLYAVVSEE------PIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYV 130 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 N +HRDL+ +N+L+ N KV DFGLAR+I+++ + +W Sbjct: 131 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG--------AKFPIKW- 181 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 APE L +++ DVWS G +L EL R +PG R L + Sbjct: 182 TAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE----------- 229 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 R Y P P DL+ + DP +R T + Sbjct: 230 ---------RGYRMPCP-----------PECPESLHDLMCQCWRKDPEERPTFEYLQA-- 267 Query: 308 YLQTYHDPNDEPEGEP 323 +L+ Y + EP+ +P Sbjct: 268 FLEDYFT-STEPQYQP 282 >2XNP-A nrPDB Length = 279 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 75/321 (23%), Positives = 131/321 (40%), Gaps = 62/321 (19%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTL-RE 59 MP R + D+++ +G G+YG K G+I+ K+++ + L E Sbjct: 1 MPSR-----AEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSE 55 Query: 60 IKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI-----STQMLSDDH 113 + +L+ KH NI+ ++ + +YI+ E + DL VI Q L ++ Sbjct: 56 VNLLRELKHPNIVRYYDRIIDRT---NTTLYIVMEYCEGGDLASVITKGTKERQYLDEEF 112 Query: 114 IQYFIYQTLRAVKVLHG-----SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAAD 168 + + Q A+K H V+HRDLKP+N+ ++ ++K+ DFGLARI++ Sbjct: 113 VLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDT-- 170 Query: 169 NSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDY 228 S +V T +Y +PE + Y+ D+WS GC+L EL P F Sbjct: 171 --------SFAKTFVGTPYYMSPE-QMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQ 221 Query: 229 RHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQR 288 + I ++ R + + +++ R Sbjct: 222 KELAGKIRE-------------------------------GKFRRIPYRYSDELNEIITR 250 Query: 289 MLVFDPAKRITAKEALEHPYL 309 ML R + +E LE+P + Sbjct: 251 MLNLKDYHRPSVEEILENPLI 271 >3QA8-A nrPDB Length = 676 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 60/220 (27%), Positives = 98/220 (44%), Gaps = 21/220 (9%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +++K LG G +G V H+ TGE VAIK+ P R EI+I+K H N++ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVV 75 Query: 73 TIFNIQRPDSFENFNEV-YIIQELMQTD-----LHRVISTQMLSDDHIQYFIYQTLRAVK 126 + + N++ + E + L++ + L + I+ + A++ Sbjct: 76 SAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALR 135 Query: 127 VLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 LH + +IHRDLKP N+++ K+ D G A+ +D+ TE+V Sbjct: 136 YLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGEL-----------CTEFV 184 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 T Y APE +L KY+ +D WS G + E F Sbjct: 185 GTLQYLAPE-LLEQKKYTVTVDYWSFGTLAFECITGFRPF 223 >3C51-A nrPDB Length = 543 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 65/328 (19%), Positives = 119/328 (36%), Gaps = 57/328 (17%) Query: 17 SLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA--LRTLREIKILKHFKHENIITI 74 +LG G +G V + K TG++ A KK+ + E KIL I+++ Sbjct: 191 RVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSL 250 Query: 75 FNIQRPDSFENFNEVYIIQELM-QTDLHRVI-----STQMLSDDHIQYFIYQTLRAVKVL 128 +FE ++ ++ +M D+ I + ++ Q + ++ L Sbjct: 251 -----AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHL 305 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H N+I+RDLKP N+L++ + ++++ D GLA + Q+ Y T + Sbjct: 306 HQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAG----------QTKTKGYAGTPGF 355 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 APE++L Y ++D ++ G L E+ R F R + Sbjct: 356 MAPELLLGEE-YDFSVDYFALGVTLYEMIAARGPFRARGEK------------------- 395 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI-----TAKEA 303 + ++ YP + +P D + +L DP KR+ + Sbjct: 396 -VENKELKQRVLEQAVTYPD--------KFSPASKDFCEALLQKDPEKRLGFRDGSCDGL 446 Query: 304 LEHPYLQTYHDPNDEPEGEPIPPSFFEF 331 HP + E P Sbjct: 447 RTHPLFRDISWRQLEAGMLTPPFVPDSR 474 >3OMV-A nrPDB Length = 307 Score = 197 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 63/287 (21%), Positives = 119/287 (41%), Gaps = 25/287 (8%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-EIKILKHFKH 68 +S+ L + +G G++G V VA+K ++ D + R E+ +L+ +H Sbjct: 35 ASEVMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLRKTRH 91 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVISTQ--MLSDDHIQYFIYQTLRAV 125 NI+ D + I+ + + L++ + Q + QT + + Sbjct: 92 VNILLFMGYMTKD------NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGM 145 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 LH N+IHRD+K +N+ ++ +K+ DFGLA + + + Sbjct: 146 DYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPT--------GS 197 Query: 186 RWYRAPEVM--LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 + APEV+ + +S DV+S G +L EL + + R Q++ + G G Sbjct: 198 VLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVG-RGYAS 256 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRML 290 D P+A + + + + +FP++ I+LLQ L Sbjct: 257 PDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQI-LSSIELLQHSL 302 >6NPU-A nrPDB Length = 298 Score = 197 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 113/298 (37%), Gaps = 53/298 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +D +K LG G YG V K VA+K ++ + + L+E ++K KH N Sbjct: 26 TDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK--EDTMEVEEFLKEAAVMKEIKHPN 83 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVIS---TQMLSDDHIQYFIYQTLRAVK 126 ++ + + + YII E M +L + Q ++ + Y Q A++ Sbjct: 84 LVQLLGVCTREP-----PFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 138 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L N IHRDL N L+ N +KV DFGL+R++ + + Sbjct: 139 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYT--------AHAGAKFPIK 190 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSD 245 W APE + K+S DVW+ G +L E+ +PG D L+ Sbjct: 191 W-TAPESL-AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE--------- 239 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 ++Y P K +L++ ++P+ R + E Sbjct: 240 -----------KDYRMERPEGCP-----------EKVYELMRACWQWNPSDRPSFAEI 275 >2VD5-A nrPDB Length = 412 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 67/349 (19%), Positives = 125/349 (35%), Gaps = 62/349 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 DF++ ++G GA+ V K TG++ A+K + +D K E +L + Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQEL-MQTDLHRVIST--QMLSDDHIQYFIYQTLRAV 125 I + +F++ N +Y++ E + DL ++S + + + ++++ + + A+ Sbjct: 121 RWITQLH-----FAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAI 175 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 +H +HRD+KP N+L++ +++ DFG + S V T Sbjct: 176 DSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVA---------VGT 226 Query: 186 RWYRAPEVMLT------SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 Y +PE++ + Y D W+ G E+F + F I Sbjct: 227 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVH-- 284 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI- 298 L + V + D +QR+L P R+ Sbjct: 285 -------------------------YKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLG 318 Query: 299 --TAKEALEHPYLQTYHDPNDEPEGEPIPPSFF------EFDHYKEALT 339 A + HP+ P P F FD ++ LT Sbjct: 319 RGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLT 367 >2DQ7-X nrPDB Length = 283 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 73/326 (22%), Positives = 127/326 (38%), Gaps = 59/326 (18%) Query: 4 RIVYNISSD-FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKI 62 + V+ I + QL LG G +G V T + VAIK ++P + L E +I Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTK-VAIKTLKPGT--MSPESFLEEAQI 57 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVIST---QMLSDDHIQYFI 118 +K KH+ ++ ++ + + +YI+ E M L + + L ++ Sbjct: 58 MKKLKHDKLVQLYAVVSEE------PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMA 111 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 Q + + N IHRDL+ +N+L+ + K+ DFGLAR+I+++ + Sbjct: 112 AQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQG------ 165 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFG 237 +W APE L +++ DVWS G +L EL R +PG + R L + Sbjct: 166 --AKFPIKW-TAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVER 221 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 P + + +L+ DP +R Sbjct: 222 GYRMPCPQDCPISLH-------------------------------ELMIHCWKKDPEER 250 Query: 298 ITAKEALEHPYLQTYHDPNDEPEGEP 323 T + +L+ Y EP+ +P Sbjct: 251 PTFEYLQS--FLEDYFT-ATEPQYQP 273 >3ORP-A nrPDB Length = 311 Score = 197 bits (500), Expect = 7e-51, Method: Composition-based stats. Identities = 59/244 (24%), Positives = 101/244 (41%), Gaps = 13/244 (5%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP--FDKPLFALRTLREIKI 62 ++S ++L +LG G V A VA+K + P F LR RE + Sbjct: 6 TPSHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQN 65 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQM-LSDDHIQYFIYQ 120 H I+ +++ ++ YI+ E + L ++ T+ ++ I Sbjct: 66 AAALNHPAIVAVYDTGEAETPAGPLP-YIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIAD 124 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 +A+ H + +IHRD+KP+N++I++ +KV DFG+AR I +S ++ Sbjct: 125 ACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQ-------TA 177 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG 240 + T Y +PE + DV+S GC+L E+ P F G Sbjct: 178 AVIGTAQYLSPEQARGDSV-DARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDP 236 Query: 241 TPHS 244 P S Sbjct: 237 IPPS 240 >4KIK-B nrPDB Length = 677 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 72/296 (24%), Positives = 119/296 (40%), Gaps = 29/296 (9%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +++K LG G +G V ++ TGE +AIK+ P R EI+I++ H N++ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVV 80 Query: 73 TIFNIQRPDSFENFNEV-YIIQELMQTD-----LHRVISTQMLSDDHIQYFIYQTLRAVK 126 ++ N++ + E Q L++ + L + I + A++ Sbjct: 81 AARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALR 140 Query: 127 VLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 LH + +IHRDLKP N+++ K+ D G A+ +D+ + T +V Sbjct: 141 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSL-----------CTSFV 189 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 T Y APE +L KY+ +D WS G + E F Q Sbjct: 190 GTLQYLAPE-LLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQ----K 244 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 S+ D+ E S YP + R+ LQ ML++ P +R T Sbjct: 245 SEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW----LQLMLMWHPRQRGT 296 >6GVJ-A nrPDB Length = 429 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 125/321 (38%), Gaps = 60/321 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-EIKILKHFK--HE 69 + + +G G V + +I AIK + + L + R EI L + + Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-LSDDHIQYFIYQTLRAVKVL 128 II +++ + D + +Y++ E DL+ + + + + + L AV + Sbjct: 205 KIIRLYDYEITDQY-----IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 259 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H ++H DLKP+N LI + LK+ DFG+A + +P V T Y Sbjct: 260 HQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQM--------QPDTTSVVKDSQVGTVNY 310 Query: 189 RAPEVMLT----------SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGI 238 PE + +K S DVWS GCIL + + F +Q+ + I Sbjct: 311 MPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAI 368 Query: 239 IGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFDPAKR 297 I H E FP + K + D+L+ L DP +R Sbjct: 369 IDPNH----------------------------EIEFPDIPEKDLQDVLKCCLKRDPKQR 400 Query: 298 ITAKEALEHPYLQTYHDPNDE 318 I+ E L HPY+Q P ++ Sbjct: 401 ISIPELLAHPYVQIQTHPVNQ 421 >4LFI-A nrPDB Length = 374 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 83/349 (23%), Positives = 153/349 (43%), Gaps = 61/349 (17%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK-----------------------KIEP 46 + D+++++ +G G Y V + + IK K+ P Sbjct: 39 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 98 Query: 47 FDKPLFALR---TLREIKILKHFK----------HENIITIFNIQRPDSFENFNEVYIIQ 93 P + +E +LK + H NII +F+I + + ++ Sbjct: 99 TTLPFQKDQYYTNQKE-DVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA---LVF 154 Query: 94 ELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINS-NCDLK 152 E + R++ L+D I++++++ L+A+ H ++HRD+KP N++I+ N L+ Sbjct: 155 EYVDNVDFRIL-YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 213 Query: 153 VCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCI 212 + D+GLA + N VA+R+++ PE+++ Y ++D+WS G + Sbjct: 214 LIDWGLAEFYHVNMEYNVR-----------VASRFFKGPELLVDYRMYDYSLDLWSFGTM 262 Query: 213 LAEL-FLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPL 271 LA + F R P F G QL+ I ++GT + L E RE+ + Y P Sbjct: 263 LASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFY-DMDQYIRKPW 321 Query: 272 EKMFPR------VNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHD 314 + N + IDL+ +L +D +R+TAKEA+ HP+ + Sbjct: 322 HRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 370 >4CRS-A nrPDB Length = 341 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 73/339 (21%), Positives = 138/339 (40%), Gaps = 62/339 (18%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREI 60 +R +N+ DF+ ++L G +G V A +K T E+ AIK ++ D + E Sbjct: 5 QRFQFNLQ-DFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEK 63 Query: 61 KI---LKHFKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDHIQY 116 +I + +H ++ +F F+ V + E DL I T + S+ + Sbjct: 64 RIFETVNSVRHPFLVNLFAC-----FQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVF 118 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 + + ++ LH +++RDLK NLL+++ +K+ DFGL + E G Sbjct: 119 YAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCK----------EGMGYG 168 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 + + T + APEV+ ++ Y+RA+D W G ++ E+ + FPG D I Sbjct: 169 DRTSTFCGTPEFLAPEVLTETS-YTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIV 227 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAK 296 + ++ + I +++R+L +P + Sbjct: 228 N--------------------------------DEVRYPRFLSTEAISIMRRLLRRNPER 255 Query: 297 RITAKE-----ALEHPYLQ--TYHDPNDEPEGEPIPPSF 328 R+ A E +HP+ + + D+ P P+ Sbjct: 256 RLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTI 294 >4UY9-A nrPDB Length = 323 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 74/308 (24%), Positives = 113/308 (36%), Gaps = 65/308 (21%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTL---REIKILKHFKH 68 + L+ ++G G +G V A G+ VA+K + +E K+ KH Sbjct: 10 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 67 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NII + + + + ++ E + L+RV+S + + D + + Q R + Sbjct: 68 PNIIALRGVCLKEP-----NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNY 122 Query: 128 LHGSNV---IHRDLKPSNLLIN--------SNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 LH + IHRDLK SN+LI SN LK+ DFGLAR + Sbjct: 123 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR------------EWHR 170 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 + T + APEV+ S +S+ DVWS G +L EL F G D Sbjct: 171 TTKMSAAGTYAWMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGID--------- 220 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAK 296 L + +P P K L++ DP Sbjct: 221 ----------GLAVAYGVAMNKLALPIPSTCPEPFAK-----------LMEDCWNPDPHS 259 Query: 297 RITAKEAL 304 R + L Sbjct: 260 RPSFTNIL 267 >4PDO-A nrPDB Length = 299 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 63/280 (22%), Positives = 111/280 (39%), Gaps = 26/280 (9%) Query: 2 PKRIVYNISSDFQ-----LKSLLGEGAYGVVCSATHK-PTGEI---VAIKKIEPFDKPLF 52 P + V +++ + ++G G +G V K +G+ VAIK ++ Sbjct: 20 PNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQ 79 Query: 53 ALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVISTQ--ML 109 + L E I+ F H NII + + + + II E M+ L + + + Sbjct: 80 RVDFLGEAGIMGQFSHHNIIRLEGVISK-----YKPMMIITEYMENGALDKFLREKDGEF 134 Query: 110 SDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADN 169 S + + +K L N +HRDL N+L+NSN KV DFGL+R++++ Sbjct: 135 SVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAT 194 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDY 228 +G + RW APE + + K++ A DVWS G ++ E+ + Sbjct: 195 YTTSG------GKIPIRW-TAPEAI-SYRKFTSASDVWSFGIVMWEVMTYGERPYWELSN 246 Query: 229 RHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPA 268 + I P + I + + + P Sbjct: 247 HEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPK 286 >2XYN-A nrPDB Length = 292 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 108/297 (36%), Gaps = 53/297 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +D +K LG G YG V K VA+K ++ + + L+E ++K KH N Sbjct: 32 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK--EDTMEVEEFLKEAAVMKEIKHPN 89 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHI---QYFIYQTLRAVK 126 ++ + + + YI+ E M +L + + Y Q A++ Sbjct: 90 LVQLLGVCTLEP-----PFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAME 144 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L N IHRDL N L+ N +KV DFGL+R++ + + Sbjct: 145 YLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYT--------AHAGAKFPIK 196 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSD 245 W APE + +S DVW+ G +L E+ +PG D L+ Sbjct: 197 W-TAPESL-AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLE--------- 245 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 + Y P PK +L++ + PA R + E Sbjct: 246 -----------KGYRMEQPEGCP-----------PKVYELMRACWKWSPADRPSFAE 280 >5TQX-A nrPDB Length = 655 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 66/318 (20%), Positives = 121/318 (38%), Gaps = 38/318 (11%) Query: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 + ++++ LG G +G VC H+ +AIK R EI+I+K Sbjct: 4 FGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKL 63 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQ----MLSDDHIQYFIYQT 121 H N++ ++ + + + E DL ++++ L + I + Sbjct: 64 NHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDI 123 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLI-NSNCDL--KVCDFGLARIIDESAADNSEPTGQQSG 178 ++ LH + +IHRDLKP N+++ + + K+ D G A+ +D+ Sbjct: 124 GSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGEL----------- 172 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGI 238 TE+V T Y APE + + Y+ +D WS G ++ E F Sbjct: 173 CTEFVGTLQYLAPE-LFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIK- 230 Query: 239 IGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR- 297 D +CI + + P + + + LQ ML +DP +R Sbjct: 231 ------KKDPKCIFACEEMSGEVRFSSHLPQP-NSLCSLIVEPMENWLQLMLNWDPQQRG 283 Query: 298 ----ITAKE-----ALEH 306 +T K+ ++H Sbjct: 284 GPVDLTLKQPRCFVLMDH 301 >3BBT-B nrPDB Length = 328 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 69/329 (20%), Positives = 122/329 (37%), Gaps = 34/329 (10%) Query: 2 PKRIVYNISSDFQLK--SLLGEGAYGVVCSATHKPTGEIV----AIKKIEPFDKPLFALR 55 P + I + +LK +LG GA+G V P GE V AIK + P + Sbjct: 4 PNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE 63 Query: 56 TLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM--LSDD 112 + E I+ H +++ + + + + ++ +LM L + + Sbjct: 64 FMDEALIMASMDHPHLVRLLGVCLSPTIQ------LVTQLMPHGCLLEYVHEHKDNIGSQ 117 Query: 113 HIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEP 172 + + Q + + L ++HRDL N+L+ S +K+ DFGLAR+++ + + Sbjct: 118 LLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNAD 177 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIF---PGRDY 228 G+ + +W A E + K++ DVWS G + EL + P R+ Sbjct: 178 GGK-------MPIKW-MALECI-HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREI 228 Query: 229 RHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQR 288 L + P D+ + S P + E +P QR Sbjct: 229 PDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDP------QR 282 Query: 289 MLVFDPAKRITAKEALEHPYLQTYHDPND 317 LV R+ + + Q D D Sbjct: 283 YLVIQGDDRMKLPSPNDSKFFQNLLDEED 311 >2OGV-A nrPDB Length = 317 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 116/326 (35%), Gaps = 68/326 (20%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHKPTGEI-----VAIKKIEPFDKPL 51 P ++ YN +F Q LG GA+G V AT G+ VA+K ++ Sbjct: 24 PTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD 83 Query: 52 FALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQ-- 107 + E+KI+ H +HENI+ + V +I E DL + + Sbjct: 84 EKEALMSELKIMSHLGQHENIVNLLGACTHG-----GPVLVITEYCCYGDLLNFLRRKAE 138 Query: 108 ---------MLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGL 158 L + +F Q + + L N IHRD+ N+L+ + K+ DFGL Sbjct: 139 ADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGL 198 Query: 159 ARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL 218 AR I + + + + +W APE + Y+ DVWS G +L E+F Sbjct: 199 ARDIMNDSNYIVKGNAR-------LPVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFS 249 Query: 219 -RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR 277 +PG + + Y + P + + + Sbjct: 250 LGLNPYPGILVNSKFYKLVKD-------------------GYQMAQPAFAPKNIYSI--- 287 Query: 278 VNPKGIDLLQRMLVFDPAKRITAKEA 303 +Q +P R T ++ Sbjct: 288 --------MQACWALEPTHRPTFQQI 305 >4UYA-A nrPDB Length = 340 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 74/318 (23%), Positives = 118/318 (37%), Gaps = 71/318 (22%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE---PFDKPLFALRTLREIKI 62 V+ +LK L+G G +G V AT + G+ VA+K D A RE ++ Sbjct: 21 VHVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARL 78 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQT 121 +H NII + + + ++ E + L+R ++ + + + + Q Sbjct: 79 FAMLRHPNIIELRGVCLQQP-----HLCLVLEFARGGALNRALAGRRIPPHVLVNWAVQI 133 Query: 122 LRAVKVLHGSN---VIHRDLKPSNLLINS--------NCDLKVCDFGLARIIDESAADNS 170 R + LH ++HRDLK SN+L+ N LK+ DFGLAR Sbjct: 134 ARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR---------- 183 Query: 171 EPTGQQSGMTEYVATRW---YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 + T +AT + APEV+ S+ +S+ D+WS G +L EL + G D Sbjct: 184 -----EWHRTTKMATAGAYAWMAPEVI-KSSLFSKGSDIWSYGVLLWELLTGEVPYRGID 237 Query: 228 YRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQ 287 L + +P P K L++ Sbjct: 238 -------------------GLAVAYGVAVNKLTLPIPSTCPEPFAK-----------LMK 267 Query: 288 RMLVFDPAKRITAKEALE 305 DP R + LE Sbjct: 268 ECWQQDPHIRPSFALILE 285 >5H2U-A nrPDB Length = 267 Score = 194 bits (492), Expect = 6e-50, Method: Composition-based stats. Identities = 74/300 (24%), Positives = 110/300 (36%), Gaps = 54/300 (18%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +F L LG G +G V K VAIK I D L EI+ +K +H++ Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVIS-RDNLLHQQMLQSEIQAMKKLRHKH 63 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIS---TQMLSDDHIQYFIYQTLRAVK 126 I+ ++ + + VYII ELM + L ++ ++L + +Q + Sbjct: 64 ILALYAVVSVG-----DPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMC 118 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L N IHRDL N+L+ N KV DFGLAR+I E + + Sbjct: 119 YLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYK--------- 169 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSD 245 + APE + + YS DVWS G +L E+F + +PG L + P Sbjct: 170 -WTAPEAL-SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPL 227 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 + L+ DP +R T K E Sbjct: 228 ECPPSVHK-------------------------------LMLTCWCRDPEQRPTFKALRE 256 >5UUU-A nrPDB Length = 547 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 71/352 (20%), Positives = 130/352 (36%), Gaps = 68/352 (19%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR--TLREIKILKHF-- 66 +DF + ++G G +G V TG++ A+K ++ + L E +L Sbjct: 198 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 257 Query: 67 -KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-LSDDHIQYFIYQTLR 123 I+ +F +++ I +LM DLH +S S+ ++++ + + Sbjct: 258 GDCPFIV-----CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 312 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 ++ +H V++RDLKP+N+L++ + +++ D GLA + S V Sbjct: 313 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS------------V 360 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 T Y APEV+ Y + D +S GC+L +L F + Sbjct: 361 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD------------- 407 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI----- 298 + ++ +P+ LL+ +L D +R+ Sbjct: 408 ----------------KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGR 451 Query: 299 TAKEALEHPYL----------QTYHDPNDEPEGEPIPPSFFEFDHYKEALTT 340 A+E E P+ Q Y P P GE F+ + E T Sbjct: 452 GAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 503 >4XCU-A nrPDB Length = 300 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 68/324 (20%), Positives = 117/324 (36%), Gaps = 64/324 (19%) Query: 1 MPKRIVYNIS-SDFQLKSLLGEGAYGVVCSAT-------HKPTGEIVAIKKIEPFDKPLF 52 +P ++ L LGEG +G V A VA+K ++ Sbjct: 6 LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD 65 Query: 53 ALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-- 108 + E++++K +H+NII + + + +Y+I E + +L + + Sbjct: 66 LADLVSEMEVMKLIGRHKNIINLLGVCTQE-----GPLYVIVECAAKGNLREFLRARRPP 120 Query: 109 ------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARII 162 LS + YQ R ++ L IHRDL N+L+ + +K+ DFGLAR + Sbjct: 121 GSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGV 180 Query: 163 DESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRP 221 G+ + +W APE + Y+ DVWS G +L E+F Sbjct: 181 HHIDYYKKTSNGR-------LPVKW-MAPEALFDRV-YTHQSDVWSFGILLWEIFTLGGS 231 Query: 222 IFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPK 281 +PG L+ + P P P+ Sbjct: 232 PYPGIPVEELFSLLRE--------------------GHRMDRP-----------PHCPPE 260 Query: 282 GIDLLQRMLVFDPAKRITAKEALE 305 L++ P++R T K+ +E Sbjct: 261 LYGLMRECWHAAPSQRPTFKQLVE 284 >5TUR-A nrPDB Length = 404 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 127/330 (38%), Gaps = 66/330 (20%) Query: 2 PKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFAL-----RT 56 P + + S +Q+ LLG G +G V S VAIK +E + R Sbjct: 118 PGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 177 Query: 57 LREIKILKHFKH--ENIITIFNIQRPDSFENFNEVYIIQELMQ--TDLHRVISTQM-LSD 111 E+ +LK +I + D FE + +I E + DL I+ + L + Sbjct: 178 PMEVVLLKKVSSGFSGVIRLL-----DWFERPDSFVLILERPEPVQDLFDFITERGALQE 232 Query: 112 DHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNS 170 + + F +Q L AV+ H V+HRD+K N+LI+ + +LK+ DFG ++ ++ Sbjct: 233 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV---- 288 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 T++ TR Y PE + + R+ VWS G +L ++ F + Sbjct: 289 --------YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEII 340 Query: 231 QLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRML 290 + + F RV+ + L++ L Sbjct: 341 RGQVFFRQ--------------------------------------RVSSECQHLIRWCL 362 Query: 291 VFDPAKRITAKEALEHPYLQTYHDPNDEPE 320 P+ R T +E HP++Q P + E Sbjct: 363 ALRPSDRPTFEEIQNHPWMQDVLLPQETAE 392 >3DTC-A nrPDB Length = 271 Score = 194 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 73/308 (23%), Positives = 112/308 (36%), Gaps = 65/308 (21%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTL---REIKILKHFKH 68 + L+ ++G G +G V A G+ VA+K + +E K+ KH Sbjct: 8 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 65 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 NII + + + + ++ E + L+RV+S + + D + + Q R + Sbjct: 66 PNIIALRGVCLKEP-----NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNY 120 Query: 128 LHGSNV---IHRDLKPSNLLIN--------SNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 LH + IHRDLK SN+LI SN LK+ DFGLAR + Sbjct: 121 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR------------EWHR 168 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 + + APEV+ S +S+ DVWS G +L EL F G D Sbjct: 169 TTKMSAAGAYAWMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGID--------- 218 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAK 296 L + +P P K L++ DP Sbjct: 219 ----------GLAVAYGVAMNKLALPIPSTCPEPFAK-----------LMEDCWNPDPHS 257 Query: 297 RITAKEAL 304 R + L Sbjct: 258 RPSFTNIL 265 >6FEX-A nrPDB Length = 321 Score = 193 bits (491), Expect = 8e-50, Method: Composition-based stats. Identities = 71/341 (20%), Positives = 120/341 (35%), Gaps = 74/341 (21%) Query: 2 PKRIVYNISSDFQLKSLLGEGAYGVVCSA----------------THKPTGEIVAIKKIE 45 P R+ + S + K LGEG +G V K +VA+K + Sbjct: 8 PPRVDF-PRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR 66 Query: 46 PFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVI 104 P L+E+KI+ K NII + + D + + +I + M+ DL++ + Sbjct: 67 PDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQD-----DPLCMITDYMENGDLNQFL 121 Query: 105 STQMLSDDHI--------------QYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCD 150 S L D + Q ++ L N +HRDL N L+ N Sbjct: 122 SAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT 181 Query: 151 LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCG 210 +K+ DFG++R + + + RW A E +L K++ A DVW+ G Sbjct: 182 IKIADFGMSRNLYAGDYYRVQGRA-------VLPIRW-MAWECILM-GKFTTASDVWAFG 232 Query: 211 CILAE--LFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPA 268 L E + R F G+ Q++ A E+ + Sbjct: 233 VTLWEVLMLCRAQPF-GQLTDEQVI--------------------ENAGEFFRDQGRQVY 271 Query: 269 APLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 P+ +L+ R + +R + H +L Sbjct: 272 LSRPPACPQ---GLYELMLRCWSRESEQRPPFSQL--HRFL 307 >3KUL-B nrPDB Length = 325 Score = 193 bits (491), Expect = 8e-50, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 109/299 (36%), Gaps = 32/299 (10%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEI---VAIKKIEPFDKPLFALRTLREIKILKHF 66 +S ++ ++G G G VC + G+ VAIK ++ L E I+ F Sbjct: 48 ASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQF 107 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQ--MLSDDHIQYFIYQTLR 123 H NII + + I+ E M+ L + T + + + Sbjct: 108 DHPNIIRLEGVVTRGRLA-----MIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGA 162 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 ++ L +HRDL N+L++SN KV DFGL+R++++ TG + Sbjct: 163 GMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTG------GKI 216 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAE-LFLRRPIFPGRDYRHQLLLIFGIIGTP 242 RW APE + +S A DVWS G ++ E L + R + + P Sbjct: 217 PIRW-TAPEAI-AFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLP 274 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAK-RITA 300 + + K P F ++ L++ P R TA Sbjct: 275 APMGCPHALHQLMLDCWHKDRAQRPR------FSQIVSVLDALIRS-----PESLRATA 322 >3BEA-A nrPDB Length = 333 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 71/330 (21%), Positives = 117/330 (35%), Gaps = 72/330 (21%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHKPTGEI-----VAIKKIEPFDKPL 51 P ++ YN +F Q LG GA+G V AT G+ VA+K ++ Sbjct: 32 PTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD 91 Query: 52 FALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQ-- 107 + E+KI+ H +HENI+ + V +I E DL + + Sbjct: 92 EKEALMSELKIMSHLGQHENIVNLLGACTHG-----GPVLVITEYCCYGDLLNFLRRKSR 146 Query: 108 -------------MLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVC 154 LS + +F Q + + L N IHRD+ N+L+ + K+ Sbjct: 147 VLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIG 206 Query: 155 DFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILA 214 DFGLAR I + + + + +W APE + Y+ DVWS G +L Sbjct: 207 DFGLARDIMNDSNYIVKGNAR-------LPVKW-MAPESIFDCV-YTVQSDVWSYGILLW 257 Query: 215 ELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEK 273 E+F +PG + + Y + P + + Sbjct: 258 EIFSLGLNPYPGILVNSKFYKLVKD-------------------GYQMAQPAFAPKNIYS 298 Query: 274 MFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 + +Q +P R T ++ Sbjct: 299 I-----------MQACWALEPTHRPTFQQI 317 >3TT0-A nrPDB Length = 382 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 71/334 (21%), Positives = 120/334 (35%), Gaps = 73/334 (21%) Query: 1 MPKRIVYNIS-SDFQLKSLLGEGAYGVVCSA------THKPTGE-IVAIKKIEPFDKPLF 52 +P+ + + L LGEGA+G V A KP VA+K ++ Sbjct: 58 LPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 117 Query: 53 ALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-- 108 + E++++K KH+NII + D +Y+I E + +L + + Sbjct: 118 LSDLISEMEMMKMIGKHKNIINLLGACTQD-----GPLYVIVEYASKGNLREYLQARRPP 172 Query: 109 ---------------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKV 153 LS + YQ R ++ L IHRDL N+L+ + +K+ Sbjct: 173 GLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 232 Query: 154 CDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCIL 213 DFGLAR I G+ + +W APE + Y+ DVWS G +L Sbjct: 233 ADFGLARDIHHIDYYKKTTNGR-------LPVKW-MAPEALFDRI-YTHQSDVWSFGVLL 283 Query: 214 AELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLE 272 E+F +PG +F ++ H + + Sbjct: 284 WEIFTLGGSPYPGVPVEE----LFKLLKEGHRMDKPSNCTNELYM--------------- 324 Query: 273 KMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 +++ P++R T K+ +E Sbjct: 325 ------------MMRDCWHAVPSQRPTFKQLVED 346 >3PVW-A nrPDB Length = 695 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 71/352 (20%), Positives = 130/352 (36%), Gaps = 68/352 (19%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR--TLREIKILKHF-- 66 +DF + ++G G +G V TG++ A+K ++ + L E +L Sbjct: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVST 248 Query: 67 -KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-LSDDHIQYFIYQTLR 123 I+ +F +++ I +LM DLH +S S+ ++++ + + Sbjct: 249 GDCPFIV-----CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL 303 Query: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 ++ +H V++RDLKP+N+L++ + +++ D GLA + S V Sbjct: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS------------V 351 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 T Y APEV+ Y + D +S GC+L +L F + Sbjct: 352 GTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD------------- 398 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI----- 298 + ++ +P+ LL+ +L D +R+ Sbjct: 399 ----------------KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGR 442 Query: 299 TAKEALEHPYL----------QTYHDPNDEPEGEPIPPSFFEFDHYKEALTT 340 A+E E P+ Q Y P P GE F+ + E T Sbjct: 443 GAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTK 494 >5HIE-A nrPDB Length = 302 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 65/302 (21%), Positives = 121/302 (40%), Gaps = 35/302 (11%) Query: 1 MPKRIVYNISSDFQL-------KSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA 53 M + S D+++ +G G++G V VA+K + P Sbjct: 19 MKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML----TPQQL 71 Query: 54 LRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIS--TQMLS 110 E+ +L+ +H NI+ ++ I+ + + L+ + Sbjct: 72 QAFKNEVGVLRKTRHVNILLFMGYSTKP------QLAIVTQWCEGSSLYHHLHIIETKFE 125 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 + QT + + LH ++IHRDLK +N+ ++ + +K+ DFGLA + +S S Sbjct: 126 MIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV--KSRWSGS 183 Query: 171 EPTGQQSGMTEYVATRWYRAPEVM--LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDY 228 Q S + + APEV+ YS DV++ G +L EL + + + Sbjct: 184 HQFEQLS------GSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINN 237 Query: 229 RHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQR 288 R Q++ + G G D P+A + + + + +FP++ I+LL R Sbjct: 238 RDQIIFMVG-RGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS-IELLAR 295 Query: 289 ML 290 L Sbjct: 296 SL 297 >5HI2-A nrPDB Length = 283 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 60/284 (21%), Positives = 114/284 (40%), Gaps = 27/284 (9%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 + +G G++G V VA+K + P E+ +L+ +H N Sbjct: 20 GQITVGQRIGSGSFGTVYKGKWHGD---VAVKML----TPQQLQAFKNEVGVLRKTRHVN 72 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVISTQ--MLSDDHIQYFIYQTLRAVKV 127 I+ ++ I+ + + L+ + + QT R + Sbjct: 73 ILLFMGYSTKP------QLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDY 126 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 LH ++IHRDLK +N+ ++ + +K+ DFGLA + +S S Q S + Sbjct: 127 LHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATV--KSRWSGSHQFEQLS------GSIL 178 Query: 188 YRAPEVM--LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 + APEV+ S YS DV++ G +L EL + + + R Q++ + G G+ D Sbjct: 179 WMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVG-RGSLSPD 237 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 P+ + + + + FPR+ + +L + + Sbjct: 238 LSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 281 >3BGP-A nrPDB Length = 333 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 127/330 (38%), Gaps = 66/330 (20%) Query: 2 PKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFAL-----RT 56 P + + S +Q+ LLG G +G V S VAIK +E + R Sbjct: 47 PGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 106 Query: 57 LREIKILKHFKH--ENIITIFNIQRPDSFENFNEVYIIQELMQ--TDLHRVISTQM-LSD 111 E+ +LK +I + D FE + +I E + DL I+ + L + Sbjct: 107 PMEVVLLKKVSSGFSGVIRLL-----DWFERPDSFVLILERPEPVQDLFDFITERGALQE 161 Query: 112 DHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNS 170 + + F +Q L AV+ H V+HRD+K N+LI+ + +LK+ DFG ++ ++ Sbjct: 162 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV---- 217 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 T++ TR Y PE + + R+ VWS G +L ++ F + Sbjct: 218 --------YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEII 269 Query: 231 QLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRML 290 + + F RV+ + L++ L Sbjct: 270 RGQVFFRQ--------------------------------------RVSSECQHLIRWCL 291 Query: 291 VFDPAKRITAKEALEHPYLQTYHDPNDEPE 320 P+ R T +E HP++Q P + E Sbjct: 292 ALRPSDRPTFEEIQNHPWMQDVLLPQETAE 321 >1TKI-A nrPDB Length = 321 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 72/333 (21%), Positives = 135/333 (40%), Gaps = 52/333 (15%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 + + LG G +G+V + + K ++ ++ +EI IL +H N Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVK--KEISILNIARHRN 62 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQML--SDDHIQYFIYQTLRAVKV 127 I+ + +SFE+ E+ +I E + D+ I+T ++ I +++Q A++ Sbjct: 63 ILHLH-----ESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQF 117 Query: 128 LHGSNVIHRDLKPSNLLINS--NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 LH N+ H D++P N++ + + +K+ +FG AR + T Sbjct: 118 LHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTA----------- 166 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Y APEV S A D+WS G ++ L F ++ Sbjct: 167 PEYYAPEVHQHDVV-STATDMWSLGTLVYVLLSGINPF-------------------LAE 206 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 + + IE+ EY E+ F ++ + +D + R+LV + R+TA EAL+ Sbjct: 207 TNQQIIENIMNAEYTFD---------EEAFKEISIEAMDFVDRLLVKERKSRMTASEALQ 257 Query: 306 HPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEAL 338 HP+L+ + + + K+ L Sbjct: 258 HPWLKQKIERVSTKVIRTLKHRRYYHTLIKKDL 290 >4EQM-A nrPDB Length = 294 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 62/223 (27%), Positives = 98/223 (43%), Gaps = 19/223 (8%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHF 66 I+ +++ LG G V A VAIK I P +K R RE+ Sbjct: 9 INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQL 68 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQM-LSDDHIQYFIYQTLRA 124 H+NI+++ ++ D Y++ E ++ L I + LS D F Q L Sbjct: 69 SHQNIVSMIDVDEEDDC-----YYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDG 123 Query: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 +K H ++HRD+KP N+LI+SN LK+ DFG+A+ + E++ + Sbjct: 124 IKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQ---------TNHVLG 174 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 T Y +PE A D++S G +L E+ + P F G Sbjct: 175 TVQYFSPEQAKGEAT-DECTDIYSIGIVLYEMLVGEPPFNGET 216 >5HVK-A nrPDB Length = 315 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 75/311 (24%), Positives = 123/311 (39%), Gaps = 45/311 (14%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 SD +LG+G +G TH+ TGE++ +K++ FD+ L+E+K+++ +H N Sbjct: 14 SDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQR-TFLKEVKVMRCLEHPN 72 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIST--QMLSDDHIQYFIYQTLRAVKV 127 ++ + D NF I E ++ L +I + F + Sbjct: 73 VLKFIGVLYKDKRLNF-----ITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAY 127 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAAD----NSEPTGQQSGMTEYV 183 LH N+IHR+L N L+ N ++ V DFGLAR++ + S + V Sbjct: 128 LHSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVV 187 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 ++ APE M+ Y +DV+S G +L E+ IG + Sbjct: 188 GNPYWMAPE-MINGRSYDEKVDVFSFGIVLCEI----------------------IGRVN 224 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 +D D L Y F + + DL DP KR + + Sbjct: 225 ADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDL-------DPEKRPSFVK- 276 Query: 304 LEHPYLQTYHD 314 LEH +L+T Sbjct: 277 LEH-WLETLRM 286 >6BSD-A nrPDB Length = 876 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 71/347 (20%), Positives = 120/347 (34%), Gaps = 80/347 (23%) Query: 2 PKRIVYNISSDFQLKSLLGEGAYGVVCSA----------------THKPTGEIVAIKKIE 45 P R+ + S + K LGEG +G V K +VA+K + Sbjct: 563 PPRVDF-PRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR 621 Query: 46 PFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVI 104 P L+E+KI+ K NII + + D + + +I + M+ DL++ + Sbjct: 622 PDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQD-----DPLCMITDYMENGDLNQFL 676 Query: 105 STQMLSDDHI--------------------QYFIYQTLRAVKVLHGSNVIHRDLKPSNLL 144 S L D + Q ++ L N +HRDL N L Sbjct: 677 SAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCL 736 Query: 145 INSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAM 204 + N +K+ DFG++R + + + RW A E +L K++ A Sbjct: 737 VGENFTIKIADFGMSRNLYAGDYYRVQGRA-------VLPIRW-MAWECILM-GKFTTAS 787 Query: 205 DVWSCGCILAE--LFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKS 262 DVW+ G L E + R F G+ Q++ A E+ + Sbjct: 788 DVWAFGVTLWEVLMLCRAQPF-GQLTDEQVI--------------------ENAGEFFRD 826 Query: 263 LPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 P+ +L+ R + +R + H +L Sbjct: 827 QGRQVYLSRPPACPQ---GLYELMLRCWSRESEQRPPFSQL--HRFL 868 >3PP0-A nrPDB Length = 338 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 61/293 (20%), Positives = 107/293 (36%), Gaps = 27/293 (9%) Query: 2 PKRIVYNISSDFQL--KSLLGEGAYGVVCSATHKPTGEIV----AIKKIEPFDKPLFALR 55 P + + I + +L +LG GA+G V P GE V AIK + P Sbjct: 6 PNQALLRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKE 65 Query: 56 TLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQ 115 L E ++ + + I + + ++ L+ H + L + Sbjct: 66 ILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLD---HVRENRGRLGSQDLL 122 Query: 116 YFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQ 175 + Q + + L ++HRDL N+L+ S +K+ DFGLAR++D + G+ Sbjct: 123 NWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGK 182 Query: 176 QSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIF---PGRDYRHQ 231 V +W A E +L +++ DVWS G + EL + P R+ Sbjct: 183 -------VPIKW-MALESIL-RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDL 233 Query: 232 LLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGID 284 L + P D+ I + P + ++ + D Sbjct: 234 LEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRF-----RELVSEFSRMARD 281 >3KRL-A nrPDB Length = 335 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 71/332 (21%), Positives = 117/332 (35%), Gaps = 74/332 (22%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHKPTGEI-----VAIKKIEPFDKPL 51 P ++ YN +F Q LG GA+G V AT G+ VA+K ++ Sbjct: 32 PTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD 91 Query: 52 FALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM- 108 + E+KI+ H +HENI+ + V +I E DL + + Sbjct: 92 EKEALMSELKIMSHLGQHENIVNLLGACTHG-----GPVLVITEYCCYGDLLNFLRRKRP 146 Query: 109 ----------------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLK 152 LS + +F Q + + L N IHRD+ N+L+ + K Sbjct: 147 PGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAK 206 Query: 153 VCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCI 212 + DFGLAR I + + + + +W APE + Y+ DVWS G + Sbjct: 207 IGDFGLARDIMNDSNYIVKGNAR-------LPVKW-MAPESIFDCV-YTVQSDVWSYGIL 257 Query: 213 LAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPL 271 L E+F +PG + + Y + P + + Sbjct: 258 LWEIFSLGLNPYPGILVNSKFYKLVKD-------------------GYQMAQPAFAPKNI 298 Query: 272 EKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 + +Q +P R T ++ Sbjct: 299 YSI-----------MQACWALEPTHRPTFQQI 319 >5A46-A nrPDB Length = 386 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 70/334 (20%), Positives = 119/334 (35%), Gaps = 73/334 (21%) Query: 1 MPKRIVYNIS-SDFQLKSLLGEGAYGVVCSA------THKPTGE-IVAIKKIEPFDKPLF 52 +P+ + + L LGEG +G V A KP VA+K ++ Sbjct: 29 LPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 88 Query: 53 ALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-- 108 + E++++K KH+NII + D +Y+I E + +L + + Sbjct: 89 LSDLISEMEMMKMIGKHKNIINLLGACTQD-----GPLYVIVEYASKGNLREYLQARRPP 143 Query: 109 ---------------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKV 153 LS + YQ R ++ L IHRDL N+L+ + +K+ Sbjct: 144 GLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 203 Query: 154 CDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCIL 213 DFGLAR I G+ + +W APE + Y+ DVWS G +L Sbjct: 204 ADFGLARDIHHIDYYKKTTNGR-------LPVKW-MAPEALFDRI-YTHQSDVWSFGVLL 254 Query: 214 AELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLE 272 E+F +PG +F ++ H + + Sbjct: 255 WEIFTLGGSPYPGVPVEE----LFKLLKEGHRMDKPSNCTNELYM--------------- 295 Query: 273 KMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 +++ P++R T K+ +E Sbjct: 296 ------------MMRDCWHAVPSQRPTFKQLVED 317 >3HMP-A nrPDB Length = 342 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 125/321 (38%), Gaps = 60/321 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-EIKILKHFK--HE 69 + + +G G V + +I AIK + + L + R EI L + + Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-LSDDHIQYFIYQTLRAVKVL 128 II +++ + D + +Y++ E DL+ + + + + + L AV + Sbjct: 117 KIIRLYDYEITDQY-----IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 171 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H ++H DLKP+N LI + LK+ DFG+A + +P V T Y Sbjct: 172 HQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQM--------QPDTTSVVKDSQVGTVNY 222 Query: 189 RAPEVMLT----------SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGI 238 PE + +K S DVWS GCIL + + F +Q+ + I Sbjct: 223 MPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAI 280 Query: 239 IGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFDPAKR 297 I H E FP + K + D+L+ L DP +R Sbjct: 281 IDPNH----------------------------EIEFPDIPEKDLQDVLKCCLKRDPKQR 312 Query: 298 ITAKEALEHPYLQTYHDPNDE 318 I+ E L HPY+Q P ++ Sbjct: 313 ISIPELLAHPYVQIQTHPVNQ 333 >3LLT-A nrPDB Length = 360 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 74/341 (21%), Positives = 136/341 (39%), Gaps = 60/341 (17%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 F + +G+G +G V H + A+K + K + + E ILK ++++I Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKI--EADILKKIQNDDIN 94 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ---MLSDDHIQYFIYQTLRAVKVLH 129 ++ F ++ + +I E + L+ +I+ + I+ + + L+A+ L Sbjct: 95 NNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLR 154 Query: 130 GSNVIHRDLKPSNLLINS-------------------------NCDLKVCDFGLARIIDE 164 ++ H DLKP N+L++ + +K+ DFG A Sbjct: 155 KMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCA----- 209 Query: 165 SAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFP 224 T + + TR YRAPEV+L + + D+WS GC+LAEL+ +F Sbjct: 210 --------TFKSDYHGSIINTRQYRAPEVILNLG-WDVSSDMWSFGCVLAELYTGSLLFR 260 Query: 225 GRDYRHQLLLIFGII---------------GTPHSDNDLRCIESPRAREYIKSLPMYPAA 269 ++ L ++ II G+ + + D + P I S+ + Sbjct: 261 THEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSI-KHVKK 319 Query: 270 PLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 L + D L +L DP R + E L+H +L+ Sbjct: 320 CLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >4R7H-A nrPDB Length = 343 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 71/339 (20%), Positives = 117/339 (34%), Gaps = 81/339 (23%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHKPTGEI-----VAIKKIEPFDKPL 51 P ++ YN +F Q LG GA+G V AT G+ VA+K ++ Sbjct: 36 PTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD 95 Query: 52 FALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQ-- 107 + E+KI+ H +HENI+ + V +I E DL + + Sbjct: 96 EKEALMSELKIMSHLGQHENIVNLLGACTHG-----GPVLVITEYCTYGDLLNFLRRKAE 150 Query: 108 ----------------------MLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLI 145 L + +F Q + + L N IHRD+ N+L+ Sbjct: 151 AMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL 210 Query: 146 NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMD 205 + K+ DFGLAR I + + + + +W APE + S Y+ D Sbjct: 211 TNGHVAKIGDFGLARDIMNDSNYIVKGNAR-------LPVKW-MAPESIFDSV-YTVQSD 261 Query: 206 VWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLP 264 VWS G +L E+F +PG + + Y + P Sbjct: 262 VWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKD-------------------GYQMAQP 302 Query: 265 MYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 + + + +Q +P R T ++ Sbjct: 303 AFAPKNIYSI-----------MQACWALEPTHRPTFQQI 330 >3GQL-A nrPDB Length = 326 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 71/334 (21%), Positives = 120/334 (35%), Gaps = 73/334 (21%) Query: 1 MPKRIVYNIS-SDFQLKSLLGEGAYGVVCSA------THKPTGE-IVAIKKIEPFDKPLF 52 +P+ + + L LGEGA+G V A KP VA+K ++ Sbjct: 17 LPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKD 76 Query: 53 ALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-- 108 + E++++K KH+NII + D +Y+I E + +L + + Sbjct: 77 LSDLISEMEMMKMIGKHKNIINLLGACTQD-----GPLYVIVEYASKGNLREYLQARRPP 131 Query: 109 ---------------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKV 153 LS + YQ R ++ L IHRDL N+L+ + +K+ Sbjct: 132 GLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 191 Query: 154 CDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCIL 213 DFGLAR I G+ + +W APE + Y+ DVWS G +L Sbjct: 192 ADFGLARDIHHIDYYKKTTNGR-------LPVKW-MAPEALFDRI-YTHQSDVWSFGVLL 242 Query: 214 AELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLE 272 E+F +PG +F ++ H + + Sbjct: 243 WEIFTLGGSPYPGVPVEE----LFKLLKEGHRMDKPSNCTNELYM--------------- 283 Query: 273 KMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 +++ P++R T K+ +E Sbjct: 284 ------------MMRDCWHAVPSQRPTFKQLVED 305 >4RC3-A nrPDB Length = 289 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 74/323 (22%), Positives = 125/323 (38%), Gaps = 66/323 (20%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFAL-----RTLREIKIL 63 + S +Q+ LLG G +G V S VAIK +E + R E+ +L Sbjct: 10 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 69 Query: 64 KHFKH--ENIITIFNIQRPDSFENFNEVYIIQELMQ--TDLHRVISTQM-LSDDHIQYFI 118 K +I + D FE + +I E + DL I+ + L ++ + F Sbjct: 70 KKVSSGFSGVIRLL-----DWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 124 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 +Q L AV+ H V+HRD+K N+LI+ + +LK+ DFG ++ ++ Sbjct: 125 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV----------- 173 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 T++ TR Y PE + + R+ VWS G +L ++ F + + + F Sbjct: 174 -YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR 232 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 RV+ + L++ L P+ R Sbjct: 233 Q--------------------------------------RVSSECQHLIRWCLALRPSDR 254 Query: 298 ITAKEALEHPYLQTYHDPNDEPE 320 T +E HP++Q P + E Sbjct: 255 PTFEEIQNHPWMQDVLLPQETAE 277 >6B2Q-A nrPDB Length = 317 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 61/230 (26%), Positives = 100/230 (43%), Gaps = 14/230 (6%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLR 58 M R+ +S ++L+ L+ G G V A G VA+K ++ P F R Sbjct: 22 MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRA 81 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIST-QMLSDDHIQY 116 E + H I ++ + Y++ EL+ + L+ V+ LS H Sbjct: 82 EARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALD 141 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 + QT RA+++ H + ++HRD+KP N+LI +K+ DFG+A+ +D + + Sbjct: 142 MLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGM---- 197 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGR 226 + T Y APE L S A DV+S G + E + F G Sbjct: 198 -----VMGTAQYIAPEQALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 241 >4X3F-A nrPDB Length = 337 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 61/230 (26%), Positives = 100/230 (43%), Gaps = 14/230 (6%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLR 58 M R+ +S ++L+ L+ G G V A G VA+K ++ P F R Sbjct: 2 MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRA 61 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIST-QMLSDDHIQY 116 E + H I ++ + Y++ EL+ + L+ V+ LS H Sbjct: 62 EARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALD 121 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 + QT RA+++ H + ++HRD+KP N+LI +K+ DFG+A+ +D + + Sbjct: 122 MLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGM---- 177 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGR 226 + T Y APE L S A DV+S G + E + F G Sbjct: 178 -----VMGTAQYIAPEQALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 221 >4OW8-A nrPDB Length = 283 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 61/230 (26%), Positives = 100/230 (43%), Gaps = 14/230 (6%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLR 58 M R+ +S ++L+ L+ G G V A G VA+K ++ P F R Sbjct: 1 MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRA 60 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIST-QMLSDDHIQY 116 E + H I ++ + Y++ EL+ + L+ V+ LS H Sbjct: 61 EARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALD 120 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 + QT RA+++ H + ++HRD+KP N+LI +K+ DFG+A+ +D + + Sbjct: 121 MLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGM---- 176 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGR 226 + T Y APE L S A DV+S G + E + F G Sbjct: 177 -----VMGTAQYIAPEQALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 220 >5AP3-A nrPDB Length = 313 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 125/321 (38%), Gaps = 60/321 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-EIKILKHFK--HE 69 + + +G G V + +I AIK + + L + R EI L + + Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-LSDDHIQYFIYQTLRAVKVL 128 II +++ + D + +Y++ E DL+ + + + + + L AV + Sbjct: 89 KIIRLYDYEITDQY-----IYMVMECGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTI 143 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H ++H DLKP+N LI + LK+ DFG+A + +P V T Y Sbjct: 144 HQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQM--------QPDTTSVVKDSQVGTVNY 194 Query: 189 RAPEVMLT----------SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGI 238 PE + +K S DVWS GCIL + + F +Q+ + I Sbjct: 195 MPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAI 252 Query: 239 IGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFDPAKR 297 I H E FP + K + D+L+ L DP +R Sbjct: 253 IDPNH----------------------------EIEFPDIPEKDLQDVLKCCLKRDPKQR 284 Query: 298 ITAKEALEHPYLQTYHDPNDE 318 I+ E L HPY+Q P ++ Sbjct: 285 ISIPELLAHPYVQIQTHPVNQ 305 >2ZMD-A nrPDB Length = 390 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 75/321 (23%), Positives = 124/321 (38%), Gaps = 60/321 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-EIKILKHFK--HE 69 + + +G G V + +I AIK + + L + R EI L + + Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-LSDDHIQYFIYQTLRAVKVL 128 II +++ + D + +Y++ E DL+ + + + + + L AV + Sbjct: 117 KIIRLYDYEITDQY-----IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 171 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H ++H DLKP+N LI + LK+ DFG+A + +P V Y Sbjct: 172 HQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQM--------QPDTTSVVKDSQVGAVNY 222 Query: 189 RAPEVMLT----------SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGI 238 PE + +K S DVWS GCIL + + F +Q+ + I Sbjct: 223 MPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAI 280 Query: 239 IGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFDPAKR 297 I H E FP + K + D+L+ L DP +R Sbjct: 281 IDPNH----------------------------EIEFPDIPEKDLQDVLKCCLKRDPKQR 312 Query: 298 ITAKEALEHPYLQTYHDPNDE 318 I+ E L HPY+Q P ++ Sbjct: 313 ISIPELLAHPYVQIQTHPVNQ 333 >3V5Q-A nrPDB Length = 297 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 65/323 (20%), Positives = 116/323 (35%), Gaps = 70/323 (21%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATH-----KPTGEIVAIKKIEPFDKPLFALRTLRE 59 + + D LK LGEGA+G V A +VA+K ++ RE Sbjct: 9 VQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPT-LAARKDFQRE 67 Query: 60 IKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM---------- 108 ++L + +HE+I+ + + + + + ++ E M DL++ + Sbjct: 68 AELLTNLQHEHIVKFYGVC-----GDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQ 122 Query: 109 -------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARI 161 L + + Q + L + +HRDL N L+ +N +K+ DFG++R Sbjct: 123 PRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSR- 181 Query: 162 IDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RR 220 D + G + RW PE ++ K++ DVWS G IL E+F + Sbjct: 182 ------DVYSTDYYRVGGHTMLPIRW-MPPESIM-YRKFTTESDVWSFGVILWEIFTYGK 233 Query: 221 PIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNP 280 + + I R +E PR Sbjct: 234 QPWFQLSNTEVIECI----------TQGRVLERPRVCPK--------------------- 262 Query: 281 KGIDLLQRMLVFDPAKRITAKEA 303 + D++ +P +R+ KE Sbjct: 263 EVYDVMLGCWQREPQQRLNIKEI 285 >3CJF-A nrPDB Length = 309 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 69/317 (21%), Positives = 114/317 (35%), Gaps = 64/317 (20%) Query: 11 SDFQLKSLLGEGAYGVVCSA----THK-PTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 L LG GA+G V A K T VA+K ++ + E+KIL H Sbjct: 27 DRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIH 86 Query: 66 FKHE-NIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM-------------LS 110 H N++ + + +I E + +L + ++ L+ Sbjct: 87 IGHHLNVVNLLGACTKPG----GPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLT 142 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 +H+ + +Q + ++ L IHRDL N+L++ +K+CDFGLAR I + Sbjct: 143 LEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVR 202 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYR 229 + + + APE + Y+ DVWS G +L E+F +PG Sbjct: 203 KGDARLPLK--------WMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPGVKID 253 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 + R E R R + P L+ Sbjct: 254 EEFCR--------------RLKEGTRMRAPDYTTPEMYQTMLD----------------C 283 Query: 290 LVFDPAKRITAKEALEH 306 +P++R T E +EH Sbjct: 284 WHGEPSQRPTFSELVEH 300 >2WTK-B nrPDB Length = 373 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 67/341 (19%), Positives = 127/341 (37%), Gaps = 34/341 (9%) Query: 10 SSDFQLKSLLGEGAYG--VVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-EIKILKHF 66 ++L +++G+G V A +KPTGE V +++I + L+ E+ + K F Sbjct: 8 GGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLF 67 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQML---SDDHIQYFIYQTL 122 H NI+ +F NE++++ M +I T + ++ I Y + L Sbjct: 68 NHPNIVPY-----RATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVL 122 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 +A+ +H +HR +K S++LI+ + + + GL + + + Sbjct: 123 KALDYIHHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSV 180 Query: 183 VATRWYRAPEVMLTS-AKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 W +PEV+ + Y D++S G EL F +D +L+ + GT Sbjct: 181 KVLPW-LSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPF--KDMPATQMLLEKLNGT 237 Query: 242 PHSDNDLRCIESPR----------------AREYIKSLPMYPAAPLEKMFPRVNPKGIDL 285 D I + + P +P +P Sbjct: 238 VPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHF 297 Query: 286 LQRMLVFDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPP 326 +++ L +P R +A L H + + E E + P Sbjct: 298 VEQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRP 338 >3A4O-X nrPDB Length = 286 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 57/263 (21%), Positives = 109/263 (41%), Gaps = 23/263 (8%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +L LG G +G V + + + VA+K ++P + A L E ++K +H+ ++ Sbjct: 15 IKLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMSVQA--FLEEANLMKTLQHDKLV 71 Query: 73 TIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIST---QMLSDDHIQYFIYQTLRAVKVL 128 ++ + + +YII E M + L + + + + F Q + + Sbjct: 72 RLYAVVTRE-----EPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYI 126 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 N IHRDL+ +N+L++ + K+ DFGLAR+I+++ E +W Sbjct: 127 ERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREG--------AKFPIKW- 177 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 APE + ++ DVWS G +L E+ + +PGR + + P +N Sbjct: 178 TAPEAI-NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENC 236 Query: 248 LRCIESPRAREYIKSLPMYPAAP 270 + + + P Sbjct: 237 PDELYDIMKMCWKEKAEERPTFD 259 >5B2L-A nrPDB Length = 324 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 68/310 (21%), Positives = 118/310 (38%), Gaps = 52/310 (16%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKI-LKHFKHE 69 +D + +G G G V + TG ++A+K++ R L ++ + LK Sbjct: 17 NDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCP 76 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST--QMLSDDHIQYFIYQTLRAVKV 127 I+ F +F +V+I ELM T ++ + + + ++A+ Sbjct: 77 YIVQCFG-----TFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYY 131 Query: 128 L-HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L VIHRD+KPSN+L++ +K+CDFG++ + +S A T Sbjct: 132 LKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAK-----------TRSAGCA 180 Query: 187 WYRAPEVML----TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 Y APE + T Y DVWS G L EL + FP ++ + ++ ++ Sbjct: 181 AYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQ--FPYKNCKTDFEVLTKVLQEE 238 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 PL + ++ L D KR + Sbjct: 239 P--------------------------PLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNK 272 Query: 303 ALEHPYLQTY 312 LEH +++ Y Sbjct: 273 LLEHSFIKRY 282 >4IAN-A nrPDB Length = 358 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 80/338 (23%), Positives = 143/338 (42%), Gaps = 50/338 (14%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPT-GEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 + + + G+G + V A + VA+K I + L L+E++ LK Sbjct: 28 LDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR--NNELMQKTGLKELEFLKKLN 85 Query: 68 HENII-TIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM----LSDDHIQYFIYQTL 122 + ++ F + + ++ E + +L V+ L ++ + Q Sbjct: 86 DADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLF 145 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDL-KVCDFGLARIIDESAADNSEPTGQQSGMTE 181 A+K+L N++H D+KP N+L+N + + K+CDFG A + ++ T Sbjct: 146 LALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDI------------TP 193 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF----- 236 Y+ +R+YRAPE+++ + Y +D+WS GC L EL+ + +FPG+ H L L Sbjct: 194 YLVSRFYRAPEIIIGKS-YDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGK 252 Query: 237 --------GIIGTPHSDNDL--------RCIESPRAREYIKSLPMYPAAPLEKMFPRVNP 280 G+ H D +L + E + P R+ Sbjct: 253 MPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPE 312 Query: 281 K-------GIDLLQRMLVFDPAKRITAKEALEHPYLQT 311 DLL ++L+ DPAKRI+ +AL+H ++Q Sbjct: 313 DQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >5X5O-A nrPDB Length = 310 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 76/346 (21%), Positives = 122/346 (35%), Gaps = 72/346 (20%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 D Q G G++G V A + VA+KK+ L+ +E +IL H N Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL---------LKIEKEAEILSVLSHRN 65 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM---LSDDHIQYFIYQTLRAVK 126 II + + I+ E L+ I++ + DHI + + + Sbjct: 66 IIQFYGVILEPP-----NYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMH 120 Query: 127 VLHGS---NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 LH VIHRDLK N++I ++ LK+CDFG +R + V Sbjct: 121 YLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF------------HNHTTHMSLV 168 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 T + APEV+ S S D +S G +L E+ R F G Sbjct: 169 GTFPWMAPEVI-QSLPVSETCDTYSYGVVLWEMLTREVPFKG------------------ 209 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNP-KGIDLLQRMLVFDPAKRITAKE 302 E ++ + P P +LL + D KR + K+ Sbjct: 210 -------------LEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQ 256 Query: 303 ALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEAL--TTKDLKKL 346 + L++ + P+ ++ + T + LKKL Sbjct: 257 IIS--ILESMSNDTSLPDKCN--SFLHNKAEWRCEIEATLERLKKL 298 >1K9A-A nrPDB Length = 450 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 66/304 (21%), Positives = 113/304 (37%), Gaps = 62/304 (20%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 + +L +G+G +G V ++ G VA+K I+ A L E ++ +H N Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK---NDATAQAFLAEASVMTQLRHSN 247 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM---LSDDHIQYFIYQTLRAVK 126 ++ + + E +YI+ E M + L + ++ L D + F A++ Sbjct: 248 LVQLLGVI----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L G+N +HRDL N+L++ + KV DFGL + + T + + Sbjct: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD------------TGKLPVK 351 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSD 245 W APE + K+S DVWS G +L E++ R +P + Sbjct: 352 W-TAPEALREK-KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV-------------- 395 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA-- 303 +P P D+++ D A R T + Sbjct: 396 -----------------VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 Query: 304 -LEH 306 LEH Sbjct: 439 QLEH 442 >5O0Y-A nrPDB Length = 579 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 117/302 (38%), Gaps = 49/302 (16%) Query: 24 YGVVCSATHKPTGEIVAIKK--IEP----FDKPLFALRTLREIKILKHFKHENIITIFNI 77 + V A VA+K + K + RE +I K H I+ +++ Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 78 QRPDSFENFNEVYIIQELMQT-DLHRVISTQML-SDDHIQYFIYQTLRAVKVLHGSN--V 133 D+ + + E + DL + L S+ + I Q + A+K L+ + Sbjct: 357 FSLDT----DSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPI 412 Query: 134 IHRDLKPSNLLINSN---CDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRA 190 IH DLKP N+L+ + ++K+ DFGL++I+D+ + ++ + ++ T WY Sbjct: 413 IHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGM---ELTSQGAGTYWYLP 469 Query: 191 PEVMLTSA---KYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 PE + K S +DVWS G I + R F G + Q +L Sbjct: 470 PECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQDIL------------- 515 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307 E+ + P P V P+ ++R L + RI ++ P Sbjct: 516 ---QENTILKATEVQFPPKPV---------VTPEAKAFIRRCLAYRKEDRIDVQQLACDP 563 Query: 308 YL 309 YL Sbjct: 564 YL 565 >4C59-A nrPDB Length = 340 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 71/306 (23%), Positives = 121/306 (39%), Gaps = 49/306 (16%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HEN 70 +++ +L EG + V A +G A+K++ ++ ++E+ +K H N Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRA-IIQEVCFMKKLSGHPN 86 Query: 71 IITIFN---IQRPDSFENFNEVYIIQELMQTDLHRVIS----TQMLSDDHIQYFIYQTLR 123 I+ + I + +S E ++ EL + L + LS D + YQT R Sbjct: 87 IVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCR 146 Query: 124 AVKVLHGSN--VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 AV+ +H +IHRDLK NLL+++ +K+CDFG A I + + E Sbjct: 147 AVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEE 206 Query: 182 YV--ATRWYRAPEVMLTSAKY--SRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 T YR PE++ + + D+W+ GCIL L R+ F +L ++ G Sbjct: 207 ITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFE---DGAKLRIVNG 263 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 P D S L++ ML +P +R Sbjct: 264 KYSIPPHDTQYTVFHS-------------------------------LIRAMLQVNPEER 292 Query: 298 ITAKEA 303 ++ E Sbjct: 293 LSIAEV 298 >4YHJ-A nrPDB Length = 584 Score = 187 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 62/343 (18%), Positives = 129/343 (37%), Gaps = 57/343 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLF--ALRTLREIKILKHFKHEN 70 F+ +LG+G +G VC+ + TG++ A KK++ L E +IL+ + Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRF 246 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRV----ISTQMLSDDHIQYFIYQTLRAVK 126 ++++ ++E + + ++ +M + + + ++ + ++ Sbjct: 247 VVSL-----AYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLE 301 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L +++RDLKP N+L++ +++ D GLA I E + V T Sbjct: 302 DLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-----------RVRGRVGTV 350 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Y APEV+ + KY+ + D W GC++ E+ F Sbjct: 351 GYMAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPF----------------------- 386 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI-----TAK 301 + E + E + + E+ + + + + +L +P+KR+ A Sbjct: 387 -KKYKEKVKWEEVDQRIK----NDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAA 441 Query: 302 EALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHY-KEALTTKDL 343 +HP + + E P Y K+ L + Sbjct: 442 GVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQF 484 >5KMM-A nrPDB Length = 329 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 66/316 (20%), Positives = 113/316 (35%), Gaps = 69/316 (21%) Query: 11 SDFQLKSLLGEGAYGVVCSATHK-----PTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 D LK LGEGA+G V A +VA+K ++ RE ++L Sbjct: 35 RDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEAS-ESARQDFQREAELLTM 93 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM---------------- 108 +H++I+ F + + ++ E M DL+R + + Sbjct: 94 LQHQHIVRFFGVCTEG-----RPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGP 148 Query: 109 LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAAD 168 L + Q + L G + +HRDL N L+ +K+ DFG++R I + Sbjct: 149 LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY- 207 Query: 169 NSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRD 227 + G + RW PE +L K++ DVWS G +L E+F + + Sbjct: 208 ------YRVGGRTMLPIRW-MPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQLS 259 Query: 228 YRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQ 287 + I R +E PRA P+ +++ Sbjct: 260 NTEAIDCI----------TQGRELERPRAC---------------------PPEVYAIMR 288 Query: 288 RMLVFDPAKRITAKEA 303 +P +R + K+ Sbjct: 289 GCWQREPQQRHSIKDV 304 >4AT3-A nrPDB Length = 299 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 55/256 (21%), Positives = 101/256 (39%), Gaps = 36/256 (14%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATH-----KPTGEIVAIKKIEPFDKPLFALR 55 M + + + LK LGEGA+G V A + +VA+K ++ Sbjct: 3 MDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASD-NARKD 61 Query: 56 TLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM------ 108 RE ++L + +HE+I+ + + + + ++ E M DL++ + Sbjct: 62 FHREAELLTNLQHEHIVKFYGVCVEG-----DPLIMVFEYMKHGDLNKFLRAHGPDAVLM 116 Query: 109 --------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLAR 160 L+ + + Q + L + +HRDL N L+ N +K+ DFG++R Sbjct: 117 AEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR 176 Query: 161 IIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-R 219 D + G + RW PE ++ K++ DVWS G +L E+F Sbjct: 177 -------DVYSTDYYRVGGHTMLPIRW-MPPESIM-YRKFTTESDVWSLGVVLWEIFTYG 227 Query: 220 RPIFPGRDYRHQLLLI 235 + + + I Sbjct: 228 KQPWYQLSNNEVIECI 243 >2PSQ-A nrPDB Length = 370 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 68/334 (20%), Positives = 120/334 (35%), Gaps = 73/334 (21%) Query: 1 MPKRIVYNISSD-FQLKSLLGEGAYGVVCSA----THKPTGEI---VAIKKIEPFDKPLF 52 +P+ + D L LGEG +G V A K + VA+K ++ Sbjct: 70 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 129 Query: 53 ALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-- 108 + E++++K KH+NII + D +Y+I E + +L + + Sbjct: 130 LSDLVSEMEMMKMIGKHKNIINLLGACTQD-----GPLYVIVEYASKGNLREYLRARRPP 184 Query: 109 ---------------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKV 153 ++ + YQ R ++ L IHRDL N+L+ N +K+ Sbjct: 185 GMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKI 244 Query: 154 CDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCIL 213 DFGLAR I+ G+ + +W APE + Y+ DVWS G ++ Sbjct: 245 ADFGLARDINNIDYYKKTTNGR-------LPVKW-MAPEALFDRV-YTHQSDVWSFGVLM 295 Query: 214 AELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLE 272 E+F +PG +F ++ H + + Sbjct: 296 WEIFTLGGSPYPGIPVEE----LFKLLKEGHRMDKPANCTNELYM--------------- 336 Query: 273 KMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 +++ P++R T K+ +E Sbjct: 337 ------------MMRDCWHAVPSQRPTFKQLVED 358 >4K33-A nrPDB Length = 325 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 67/334 (20%), Positives = 114/334 (34%), Gaps = 73/334 (21%) Query: 1 MPKRIVYNISS-DFQLKSLLGEGAYGVVCSATHKPTGE-------IVAIKKIEPFDKPLF 52 +P + +S L LGEGA+G V A + VA+K ++ Sbjct: 25 LPADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 84 Query: 53 ALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-- 108 + E++++K KH+NII + +Y++ E + +L + + Sbjct: 85 LSDLVSEMEMMKMIGKHKNIINLLGACTQG-----GPLYVLVEYAAKGNLREFLRARRPP 139 Query: 109 ---------------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKV 153 L+ + YQ R ++ L IHRDL N+L+ + +K+ Sbjct: 140 GLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKI 199 Query: 154 CDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCIL 213 DFGLAR + G+ + +W APE + Y+ DVWS G +L Sbjct: 200 ADFGLARDVHNLDYYKETTNGR-------LPVKW-MAPEALFDRV-YTHQSDVWSFGVLL 250 Query: 214 AELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLE 272 E+F +PG L+ D C Sbjct: 251 WEIFTLGGSPYPGIPVEELFKLLKE---GHRMDKPANCTHDLYMI--------------- 292 Query: 273 KMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 ++ P++R T K+ +E Sbjct: 293 -------------MRECWHAAPSQRPTFKQLVED 313 >1FVR-A nrPDB Length = 327 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 64/315 (20%), Positives = 110/315 (34%), Gaps = 68/315 (21%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIV--AIKKIEPFDKPLFALRTLREIKILKHF-K 67 +D + + ++GEG +G V A K G + AIK+++ + E+++L Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGH 84 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-----------------L 109 H NII + E+ +Y+ E +L + L Sbjct: 85 HPNIINLLGAC-----EHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTL 139 Query: 110 SDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADN 169 S + +F R + L IHRDL N+L+ N K+ DFGL+R + Sbjct: 140 SSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYV--- 196 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 + RW A E + + Y+ DVWS G +L E Sbjct: 197 -------KKTMGRLPVRW-MAIESL-NYSVYTTNSDVWSYGVLLWE-------------- 233 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 I + GTP+ + + Y P+ + + DL+++ Sbjct: 234 -----IVSLGGTPYCGMTCAELYEKLPQGYRLEKPL-----------NCDDEVYDLMRQC 277 Query: 290 LVFDPAKRITAKEAL 304 P +R + + L Sbjct: 278 WREKPYERPSFAQIL 292 >4H1J-A nrPDB Length = 293 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 63/303 (20%), Positives = 112/303 (36%), Gaps = 49/303 (16%) Query: 6 VYNIS-SDFQLKSLLGEGAYGVVCSAT---HKPTGEIVAIKKIEPFDKPLFALRTLREIK 61 Y I+ D L +LGEG +G V HK VA+K + + + E Sbjct: 18 QYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAV 77 Query: 62 ILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQT 121 I+K+ H +I+ + I + E+Y EL L R + L + + Q Sbjct: 78 IMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGEL-GHYLER--NKNSLKVLTLVLYSLQI 134 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 +A+ L N +HRD+ N+L+ S +K+ DFGL+R I++ + T Sbjct: 135 CKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTR------- 187 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIG 240 + +W +PE + +++ A DVW + E+ + F + + + ++ Sbjct: 188 -LPIKW-MSPESI-NFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDR 244 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 P D + + L+ R +DP+ R Sbjct: 245 LPKPDLCPPVLYT-------------------------------LMTRCWDYDPSDRPRF 273 Query: 301 KEA 303 E Sbjct: 274 TEL 276 >4XLV-A nrPDB Length = 328 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 59/321 (18%), Positives = 105/321 (32%), Gaps = 69/321 (21%) Query: 11 SDFQLKSLLGEGAYGVVCS--ATHKPTGE---IVAIKKIEPFDKPLFALRTLREIKILKH 65 L LG+G++G+V A GE VA+K + + L E ++K Sbjct: 39 EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKG 98 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIS-----------TQMLSDDH 113 F +++ + + ++ ELM DL + + Sbjct: 99 FTCHHVVRLLGVVSKG-----QPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQE 153 Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPT 173 + + + L+ +HRDL N ++ + +K+ DFG+ R I E+ Sbjct: 154 MIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDY------ 207 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQL 232 + G + RW APE + ++ + D+WS G +L E+ + G L Sbjct: 208 -YRKGGKGLLPVRW-MAPESL-KDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVL 264 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 + DN + DL++ F Sbjct: 265 KFVMDGGYLDQPDNCPERVT-------------------------------DLMRMCWQF 293 Query: 293 DPAKRITAKEALE------HP 307 +P R T E + HP Sbjct: 294 NPNMRPTFLEIVNLLKDDLHP 314 >2W1I-A nrPDB Length = 326 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 114/298 (38%), Gaps = 34/298 (11%) Query: 13 FQLKSLLGEGAYGVVCSATHKP----TGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 + LG+G +G V + P TGE+VA+KK++ + REI+ILK +H Sbjct: 43 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLR-DFEREIEILKSLQH 101 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQY--FIYQTLRAV 125 +NI+ + N +I E + L + DHI+ + Q + + Sbjct: 102 DNIVKYKGVCYSAGRRNLK---LIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGM 158 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 + L IHRDL N+L+ + +K+ DFGL +++ + +S Sbjct: 159 EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGES------PI 212 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 WY APE + S K+S A DVWS G +L ELF + +IG Sbjct: 213 FWY-APESLTES-KFSVASDVWSFGVVLYELFT-----YIEKSKSPPAEFMRMIGN-DKQ 264 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 + + LP P E + + +R + ++ Sbjct: 265 GQMIVFHLIELLKNNGRLPRPDGCPDEIYMI---------MTECWNNNVNQRPSFRDL 313 >5AMN-A nrPDB Length = 299 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 113/300 (37%), Gaps = 42/300 (14%) Query: 11 SDFQLKSLLGEGAYGVVCSATH-----KPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 + L LGEG +G V AT + VA+K ++ P L E +LK Sbjct: 23 KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQ 82 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM-----------LSDDH 113 H ++I ++ D + +I E + L + L+ Sbjct: 83 VNHPHVIKLYGACSQD-----GPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGD 137 Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPT 173 + F +Q + ++ L ++HRDL N+L+ +K+ DFGL+R + E + Sbjct: 138 LISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQ 197 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQL 232 G+ + +W A E + Y+ DVWS G +L E+ +PG Sbjct: 198 GR-------IPVKW-MAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE--- 245 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 +F ++ T H R ++ P +F ++ DL ++M+V Sbjct: 246 -RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEP--DKRPVFADIS---KDL-EKMMVK 298 >5GNK-A nrPDB Length = 297 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 61/293 (20%), Positives = 110/293 (37%), Gaps = 28/293 (9%) Query: 2 PKRIVYNISSD--FQLKSLLGEGAYGVVCSATHKPTGEIV----AIKKIEPFDKPLFALR 55 P + + I + F+ +LG GA+G V P GE V AIK++ P Sbjct: 8 PNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE 67 Query: 56 TLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM--LSDD 112 L E ++ + ++ + I + + +I +LM L + + Sbjct: 68 ILDEAYVMASVDNPHVCRLLGICLTSTVQ------LIMQLMPFGCLLDYVREHKDNIGSQ 121 Query: 113 HIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEP 172 ++ + Q + + L ++HRDL N+L+ + +K+ DFGLA+++ + Sbjct: 122 YLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE 181 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIF---PGRDY 228 G+ V +W A E +L Y+ DVWS G + EL + P + Sbjct: 182 GGK-------VPIKW-MALESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEI 232 Query: 229 RHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPK 281 L + P D+ I S P + +E +P+ Sbjct: 233 SSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQ 285 >3IO7-A nrPDB Length = 313 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 114/298 (38%), Gaps = 34/298 (11%) Query: 13 FQLKSLLGEGAYGVVCSATHKP----TGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 + LG+G +G V + P TGE+VA+KK++ + REI+ILK +H Sbjct: 30 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLR-DFEREIEILKSLQH 88 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQY--FIYQTLRAV 125 +NI+ + N +I E + L + DHI+ + Q + + Sbjct: 89 DNIVKYKGVCYSAGRRNLK---LIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGM 145 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 + L IHRDL N+L+ + +K+ DFGL +++ + +S Sbjct: 146 EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGES------PI 199 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 WY APE + S K+S A DVWS G +L ELF + +IG Sbjct: 200 FWY-APESLTES-KFSVASDVWSFGVVLYELFT-----YIEKSKSPPAEFMRMIGN-DKQ 251 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 + + LP P E + + +R + ++ Sbjct: 252 GQMIVFHLIELLKNNGRLPRPDGCPDEIYMI---------MTECWNNNVNQRPSFRDL 300 >3LZB-A nrPDB Length = 327 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 60/323 (18%), Positives = 115/323 (35%), Gaps = 51/323 (15%) Query: 2 PKRIVYNISSD--FQLKSLLGEGAYGVVCSATHKPTGEIV----AIKKIEPFDKPLFALR 55 P + + I + F+ +LG GA+G V P GE V AIK++ P Sbjct: 4 PNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE 63 Query: 56 TLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQ 115 L E ++ + ++ + I + + ++ L+ + + ++ Sbjct: 64 ILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLD---YVREHKDNIGSQYLL 120 Query: 116 YFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQ 175 + Q + + L ++HRDL N+L+ + +K+ DFGLA+++ + G+ Sbjct: 121 NWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGK 180 Query: 176 QSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLL 234 V +W A E +L Y+ DVWS G + EL + G Sbjct: 181 -------VPIKW-MALESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDG--------- 222 Query: 235 IFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDP 294 + E E + LP P ++ +++ + D Sbjct: 223 -------------IPASEISSILEKGERLPQPPICTIDVYMI---------MRKCWMIDA 260 Query: 295 AKRITAKEALEHPYLQTYHDPND 317 R +E + + + DP Sbjct: 261 DSRPKFRELII-EFSKMARDPQR 282 >5VO2-A nrPDB Length = 300 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 107/291 (36%), Gaps = 61/291 (20%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +G GA G V GE VA+KK+ + IK L+ KH NIIT + Sbjct: 20 VGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD--------IKHLRKLKHPNIITFKGVC 69 Query: 79 RPDSFENFNEVYIIQELM-QTDLHRVISTQM-LSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 I+ E Q L+ V+ ++ + + + LH +IHR Sbjct: 70 TQAPC-----YCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHR 124 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 DLK N+LI + +K+ DFG ++ + + + S + T + APEV+ Sbjct: 125 DLKSPNMLITYDDVVKISDFGTSKELSDKSTKMS-----------FAGTVAWMAPEVIRN 173 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 S +D+WS G +L EL + D +I+G+ Sbjct: 174 E-PVSEKVDIWSFGVVLWELLTGEIPYKDVDSS---AIIWGV------------------ 211 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGID-LLQRMLVFDPAKRITAKEALEH 306 + L P P G LL++ P R + ++ L H Sbjct: 212 ----------GSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH 252 >4XUF-A nrPDB Length = 297 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 114/294 (38%), Gaps = 50/294 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATH---KPTGE--IVAIKKIEPFDKPLFALRTLREIKILKH 65 + + +LG GA+G V +AT TG VA+K ++ + E+K++ Sbjct: 9 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQ 68 Query: 66 F-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVI--STQMLSDDHIQY----- 116 HENI+ + +Y+I E DL + + S+D I+Y Sbjct: 69 LGSHENIVNLLGACTLS-----GPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKR 123 Query: 117 -----------------FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLA 159 F YQ + ++ L + +HRDL N+L+ +K+CDFGLA Sbjct: 124 LEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLA 183 Query: 160 RIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL- 218 R I + + + +W APE + Y+ DVWS G +L E+F Sbjct: 184 RDIMSDSNYVVRGNAR-------LPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFSL 234 Query: 219 RRPIFPGR----DYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPA 268 +PG ++ + F + ++ ++ I + P +P Sbjct: 235 GVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPN 288 >1BYG-A nrPDB Length = 278 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 113/304 (37%), Gaps = 62/304 (20%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 + +L +G+G +G V ++ G VA+K I+ A L E ++ +H N Sbjct: 21 KELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK---NDATAQAFLAEASVMTQLRHSN 75 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM---LSDDHIQYFIYQTLRAVK 126 ++ + + E +YI+ E M + L + ++ L D + F A++ Sbjct: 76 LVQLLGVI----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 131 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L G+N +HRDL N+L++ + KV DFGL + + T + + Sbjct: 132 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD------------TGKLPVK 179 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSD 245 W APE + K+S DVWS G +L E++ R +P + Sbjct: 180 W-TAPEALREK-KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV-------------- 223 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA-- 303 +P P ++++ D A R + + Sbjct: 224 -----------------VPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLRE 266 Query: 304 -LEH 306 LEH Sbjct: 267 QLEH 270 >4X7Q-B nrPDB Length = 312 Score = 184 bits (466), Expect = 6e-47, Method: Composition-based stats. Identities = 73/329 (22%), Positives = 125/329 (37%), Gaps = 70/329 (21%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP-----FDKPLFALRTLREIKILKHF 66 +++L LLG+G +G V + VAIK I + ++ E+ +L Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 67 K----HENIITIFNIQRPDSFENFNEVYIIQE--LMQTDLHRVI-STQMLSDDHIQYFIY 119 H +I + D FE ++ E L DL I L + + F Sbjct: 92 GAGGGHPGVIRLL-----DWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFG 146 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 Q + A++ H V+HRD+K N+LI+ K+ DFG ++ + Sbjct: 147 QVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD------------EP 194 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGI 238 T++ TR Y PE + ++ VWS G +L ++ F Sbjct: 195 YTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFE-------------- 240 Query: 239 IGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI 298 R +E +++ +PA V+P L++R L P+ R Sbjct: 241 ----------------RDQEILEAELHFPA--------HVSPDCCALIRRCLAPKPSSRP 276 Query: 299 TAKEALEHPYLQTYHD--PNDEPEGEPIP 325 + +E L P++QT + P + +G P P Sbjct: 277 SLEEILLDPWMQTPAEDVPLNPSKGGPAP 305 >5X02-A nrPDB Length = 347 Score = 184 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 114/294 (38%), Gaps = 50/294 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATH---KPTGE--IVAIKKIEPFDKPLFALRTLREIKILKH 65 + + +LG GA+G V +AT TG VA+K ++ + E+K++ Sbjct: 48 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQ 107 Query: 66 F-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVI--STQMLSDDHIQY----- 116 HENI+ + +Y+I E DL + + S+D I+Y Sbjct: 108 LGSHENIVNLLGACTLS-----GPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKR 162 Query: 117 -----------------FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLA 159 F YQ + ++ L + +HRDL N+L+ +K+CDFGLA Sbjct: 163 LEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLA 222 Query: 160 RIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL- 218 R I + + + +W APE + Y+ DVWS G +L E+F Sbjct: 223 RDIMSDSNYVVRGNAR-------LPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFSL 273 Query: 219 RRPIFPGR----DYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPA 268 +PG ++ + F + ++ ++ I + P +P Sbjct: 274 GVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPN 327 >3G0E-A nrPDB Length = 336 Score = 184 bits (466), Expect = 8e-47, Method: Composition-based stats. Identities = 70/335 (20%), Positives = 113/335 (33%), Gaps = 74/335 (22%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSAT-----HKPTGEIVAIKKIEPFDKPL 51 P ++ Y+ +F LG GA+G V AT VA+K ++P Sbjct: 32 PTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLT 91 Query: 52 FALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-- 108 + E+K+L + H NI+ + + I + DL + + Sbjct: 92 EREALMSELKVLSYLGNHMNIVNLLGACTIGG----PTLVITEYCCYGDLLNFLRRKRDS 147 Query: 109 -----------------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDL 151 L + + F YQ + + L N IHRDL N+L+ Sbjct: 148 FICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT 207 Query: 152 KVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGC 211 K+CDFGLAR I + + + + +W APE + Y+ DVWS G Sbjct: 208 KICDFGLARDIKNDSNYVVKGNAR-------LPVKW-MAPESIFNCV-YTFESDVWSYGI 258 Query: 212 ILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAP 270 L ELF +PG + + R + Sbjct: 259 FLWELFSLGSSPYPGMPVDSKFYKMIK--------EGFRMLSPE---------------- 294 Query: 271 LEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 + D+++ DP KR T K+ ++ Sbjct: 295 ------HAPAEMYDIMKTCWDADPLKRPTFKQIVQ 323 >5U6B-A nrPDB Length = 307 Score = 184 bits (466), Expect = 8e-47, Method: Composition-based stats. Identities = 64/305 (20%), Positives = 103/305 (33%), Gaps = 53/305 (17%) Query: 15 LKSLLGEGAYGVVCSATHKPTG--EIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENI 71 L LGEG +G V VA+K ++ L E +K F H N+ Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 72 ITIFNIQRPDS-FENFNEVYIIQELM-QTDLHRVISTQMLSDDHI-------QYFIYQTL 122 + + + S E+F +I M DLH + L D + F+ Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 ++ L IHRDL N ++N N + V DFGL++ I + G Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDY-------YRQGRIAK 199 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGT 241 + +W A E + Y+ DVWS G + E+ + +PG + + Sbjct: 200 MPVKW-IAIESLADRV-YTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQ---- 253 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 + PA L+ ++ L+ R +P R + Sbjct: 254 -------------------GNRLKQPADCLDGLYA--------LMSRCWELNPQDRPSFT 286 Query: 302 EALEH 306 E E Sbjct: 287 ELRED 291 >4HVI-A nrPDB Length = 314 Score = 183 bits (465), Expect = 8e-47, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 112/295 (37%), Gaps = 35/295 (11%) Query: 13 FQLKSLLGEGAYGVVCSATHKP----TGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 + S LG+G +G V + P TG +VA+K+++ P REI+ILK Sbjct: 12 LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HSGPDQQRDFQREIQILKALHS 70 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM--LSDDHIQYFIYQTLRAV 125 + I+ + ++ ++ E + L + L + + Q + + Sbjct: 71 DFIVKYRGVSYGPGRQSLR---LVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGM 127 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 + L +HRDL N+L+ S +K+ DFGLA+++ QS Sbjct: 128 EYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQS------PI 181 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 WY APE + + +SR DVWS G +L ELF ++G+ Sbjct: 182 FWY-APESLSDNI-FSRQSDVWSFGVVLYELFT-----YCDKSCSPSAEFLRMMGSERDV 234 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 L + + LP PA P E +L++ P R + Sbjct: 235 PALSRLLELLEEG--QRLPAPPACPAEVH---------ELMKLCWAPSPQDRPSF 278 >5O2B-A nrPDB Length = 285 Score = 183 bits (465), Expect = 9e-47, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 112/298 (37%), Gaps = 50/298 (16%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHENIITIFN 76 LG GA+ V T VA +++ R E ++LK +H NI+ ++ Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 77 IQRPDSFENFNEVYIIQELM-QTDLHRVIST-QMLSDDHIQYFIYQTLRAVKVLHGSN-- 132 + + ++ ELM L + +++ ++ + Q L+ ++ LH Sbjct: 83 -SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 141 Query: 133 VIHRDLKPSNLLINS-NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 +IHRDLK N+ I +K+ D GLA ++ S A + T + AP Sbjct: 142 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAK------------SVIGTPEFMAP 189 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCI 251 E + Y ++DV++ G + E+ + Q+ P S N + Sbjct: 190 E--MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVT-- 245 Query: 252 ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 +P+ ++++ + + ++R++ ++ L H + Sbjct: 246 ---------------------------DPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 276 >4TPT-A nrPDB Length = 303 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 51/218 (23%), Positives = 92/218 (42%), Gaps = 19/218 (8%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 D +LG+G +G THK TG+++ +K++ D+ L E+K+++ H N+ Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQ-KTFLTEVKVMRSLDHPNV 59 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIST-QMLSDDHIQYFIYQTLRAVKVLH 129 + + D ++ ++ E ++ L + + F + LH Sbjct: 60 LKFIGVLYKD-----KKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLH 114 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDE----------SAADNSEPTGQQSGM 179 +IHRDL N LI + + V DFGL+R+I E + + + Sbjct: 115 SMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKR 174 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 V ++ APE ML Y +D++S G +L E+ Sbjct: 175 YTVVGNPYWMAPE-MLNGKSYDETVDIFSFGIVLCEII 211 >3QGY-A nrPDB Length = 286 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 53/263 (20%), Positives = 105/263 (39%), Gaps = 25/263 (9%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 S+ +G G +G+V + VAIK I+ + + + E +++ H Sbjct: 27 SELTFVQEIGSGQFGLVHLGYW-LNKDKVAIKTIK--EGSMSEDDFIEEAEVMMKLSHPK 83 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVISTQM--LSDDHIQYFIYQTLRAVKV 127 ++ ++ + + + ++ E M+ L + TQ + + + + Sbjct: 84 LVQLYGVCLEQA-----PICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAY 138 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 L + VIHRDL N L+ N +KV DFG+ R + + +S +W Sbjct: 139 LEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSS--------TGTKFPVKW 190 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLI---FGIIGTPH 243 +PEV + ++YS DVWS G ++ E+F + + R + I F + Sbjct: 191 -ASPEV-FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRL 248 Query: 244 SDNDLRCIESPRAREYIKSLPMY 266 + + I + +E + P + Sbjct: 249 ASTHVYQIMNHCWKERPEDRPAF 271 >5EG3-A nrPDB Length = 334 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 68/334 (20%), Positives = 120/334 (35%), Gaps = 73/334 (21%) Query: 1 MPKRIVYNISSD-FQLKSLLGEGAYGVVCSA----THKPTGEI---VAIKKIEPFDKPLF 52 +P+ + D L LGEGA+G V A K + VA+K ++ Sbjct: 24 LPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD 83 Query: 53 ALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-- 108 + E++++K KH+NII + D +Y+I + +L + + Sbjct: 84 LSDLVSEMEMMKMIGKHKNIINLLGACTQD-----GPLYVIVAYASKGNLREYLRARRPP 138 Query: 109 ---------------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKV 153 ++ + YQ R ++ L IHRDL N+L+ N +K+ Sbjct: 139 GMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKI 198 Query: 154 CDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCIL 213 DFGLAR I+ G+ + +W APE + Y+ DVWS G ++ Sbjct: 199 ADFGLARDINNIDFFKETTNGR-------LPVKW-MAPEALFDRV-YTHQSDVWSFGVLM 249 Query: 214 AELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLE 272 E+F +PG +F ++ H + + Sbjct: 250 WEIFTLGGSPYPGIPVEE----LFKLLKEGHRMDKPANCTNELYM--------------- 290 Query: 273 KMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 +++ P++R T K+ +E Sbjct: 291 ------------MMRDCWHAVPSQRPTFKQLVED 312 >5O2C-A nrPDB Length = 380 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 112/298 (37%), Gaps = 50/298 (16%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHENIITIFN 76 LG GA+ V T VA +++ R E ++LK +H NI+ ++ Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 77 IQRPDSFENFNEVYIIQELM-QTDLHRVIST-QMLSDDHIQYFIYQTLRAVKVLHGSN-- 132 + + ++ ELM L + +++ ++ + Q L+ ++ LH Sbjct: 92 -SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 150 Query: 133 VIHRDLKPSNLLINS-NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 +IHRDLK N+ I +K+ D GLA ++ S A + T + AP Sbjct: 151 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAK------------SVIGTPEFMAP 198 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCI 251 E + Y ++DV++ G + E+ + Q+ P S N + Sbjct: 199 E--MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVT-- 254 Query: 252 ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 +P+ ++++ + + ++R++ ++ L H + Sbjct: 255 ---------------------------DPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 285 >2HK5-A nrPDB Length = 270 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 60/261 (22%), Positives = 110/261 (42%), Gaps = 24/261 (9%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +L+ LG G +G V AT+ + VA+K ++P + A L E ++K +H+ ++ Sbjct: 17 LKLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMSVEA--FLAEANVMKTLQHDKLV 73 Query: 73 TIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQ---MLSDDHIQYFIYQTLRAVKVL 128 + + + +YII E M + L + + + F Q + + Sbjct: 74 KLHAVVTKE------PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFI 127 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 N IHRDL+ +N+L++++ K+ DFGLAR+I+++ E +W Sbjct: 128 EQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREG--------AKFPIKW- 178 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 APE + ++ DVWS G +L E+ R +PG + + P +N Sbjct: 179 TAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENC 237 Query: 248 LRCIESPRAREYIKSLPMYPA 268 + + R + P Sbjct: 238 PEELYNIMMRCWKNRPEERPT 258 >6FER-A nrPDB Length = 309 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 70/319 (21%), Positives = 116/319 (36%), Gaps = 64/319 (20%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGE----------------IVAIKKIEPFDKPLFALRT 56 K LGEG +G V + + +VA+K + Sbjct: 11 LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDF 70 Query: 57 LREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQ-------- 107 L+EIKI+ K NII + + D + + +I E M+ DL++ +S Sbjct: 71 LKEIKIMSRLKDPNIIHLLAVCITD-----DPLCMITEYMENGDLNQFLSRHEPPNSSSS 125 Query: 108 ---MLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDE 164 +S ++++ Q +K L N +HRDL N L+ N +K+ DFG++R + Sbjct: 126 DVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYS 185 Query: 165 SAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFP 224 + + RW + E +L K++ A DVW+ G L E F F Sbjct: 186 GDYYRIQGRA-------VLPIRW-MSWESIL-LGKFTTASDVWAFGVTLWETFT----FC 232 Query: 225 GRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGID 284 QL +D + IE+ E+ + P + P K Sbjct: 233 QEQPYSQL-------------SDEQVIENT--GEFFRDQGRQTYLPQPAICPDSVYK--- 274 Query: 285 LLQRMLVFDPAKRITAKEA 303 L+ D R + +E Sbjct: 275 LMLSCWRRDTKNRPSFQEI 293 >4PWN-A nrPDB Length = 274 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 54/300 (18%), Positives = 111/300 (37%), Gaps = 49/300 (16%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIEPFD-KPLFALRTLREIKILKHFKHENIITIFN 76 +G G++ V T VA +++ R E ++LK +H NI+ ++ Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYD 76 Query: 77 IQRPDSFENFNEVYIIQELM-QTDLHRVIST-QMLSDDHIQYFIYQTLRAVKVLHGSN-- 132 + + + ++ ELM L + +++ ++ + Q L+ ++ LH Sbjct: 77 -SWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135 Query: 133 VIHRDLKPSNLLINS-NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 +IHRDLK N+ I +K+ D GLA + + S + T + AP Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLATL-----------EKRASFAKSVIGTPEFMAP 184 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCI 251 E + KY ++DV++ G + E+ + Q+ P S + + Sbjct: 185 E--MYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAI- 241 Query: 252 ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQT 311 P+ ++++ + + +R + K+ L H + Q Sbjct: 242 ----------------------------PEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >4NEU-A nrPDB Length = 333 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 70/355 (19%), Positives = 144/355 (40%), Gaps = 47/355 (13%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLRE 59 M ++ SSDF + L G +G V H+ G ++ +K + + + L E Sbjct: 14 MSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEE 72 Query: 60 IKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQ-YF 117 K++ +H ++ + + + + ++ E M+ +L V+ +M + ++ Sbjct: 73 AKMMNRLRHSRVVKLLGVIIEE-----GKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRI 127 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESA---ADNSEPTG 174 I + + + LHG VIH+DLKP N+L++++ +K+ D GLA S +++E Sbjct: 128 ILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELRE 187 Query: 175 QQSGMTEYVATRWYRAPEVMLT-SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLL 233 + T +Y APE + +AK + DV+S +L +F + + QL+ Sbjct: 188 VDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLI 247 Query: 234 LIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFD 293 + P D+ + + PR + I L++ + Sbjct: 248 MCIKSGNRPDVDD------------------------ITEYCPR---EIISLMKLCWEAN 280 Query: 294 PAKRITAKEALE--HPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKL 346 P R T E P+ + + + E + + + + ++ E K ++ L Sbjct: 281 PEARPTFPGIEEKFRPFYLSQLEESVEEDVKSL-----KKEYSNENAVVKRMQSL 330 >4PL5-B nrPDB Length = 435 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 83/356 (23%), Positives = 145/356 (40%), Gaps = 67/356 (18%) Query: 13 FQLKSLLGEGAYGV-VCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HEN 70 F K +LG GA G V VA+K+I P RE+++L+ H N Sbjct: 29 FCPKDVLGHGAEGTIVYKGMF--DNRDVAVKRILPECFSFAD----REVQLLRESDEHPN 82 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHI--QYFIYQTLRAVKVL 128 +I F ++ F+ YI EL L + + + + ++QT + L Sbjct: 83 VIRYFCTEKDRQFQ-----YIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHL 137 Query: 129 HGSNVIHRDLKPSNLLI---NSNCDLK--VCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 H N++HRDLKP N+L+ N++ +K + DFGL + + S +G Sbjct: 138 HSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVP------- 190 Query: 184 ATRWYRAPEVMLTSAKY--SRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIG 240 T + APE++ K + +D++S GC+ + F G+ + Q ++ G Sbjct: 191 GTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGAC- 248 Query: 241 TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITA 300 +L C S + + I +L+++M+ DP +R +A Sbjct: 249 ------NLDCFHSDKHEDVI---------------------ARELIEKMIAMDPQQRPSA 281 Query: 301 KEALEHPYL-------QTYHDPNDEPEGEPIP-PSFFEFDHYKEALTTKDLKKLIW 348 K L+HP+ Q + D +D E E + P + + A+ D ++ I Sbjct: 282 KHVLKHPFFWSLEKQLQFFQDVSDRIEKEALDGPIVRQLERGGRAVVKMDWRENIT 337 >2PL0-A nrPDB Length = 289 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 58/263 (22%), Positives = 109/263 (41%), Gaps = 27/263 (10%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +L LG G +G V + + VA+K ++ A L E ++K +H+ ++ Sbjct: 25 LKLVERLGAGQFGEVWMGYYNGHTK-VAVKSLKQGSMSPDA--FLAEANLMKQLQHQRLV 81 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQ---MLSDDHIQYFIYQTLRAVKVL 128 ++ + + +YII E M+ L + T L+ + + Q + + Sbjct: 82 RLYAVVTQE------PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFI 135 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 N IHRDL+ +N+L++ K+ DFGLAR+I+++ E +W Sbjct: 136 EERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG--------AKFPIKW- 186 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQ---LLLIFGIIGTPHS 244 APE + ++ DVWS G +L E+ R +PG L + ++ + Sbjct: 187 TAPEAI-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNC 245 Query: 245 DNDLRCIESPRAREYIKSLPMYP 267 +L + +E + P + Sbjct: 246 PEELYQLMRLCWKERPEDRPTFD 268 >3Q4U-A nrPDB Length = 301 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 108/310 (34%), Gaps = 37/310 (11%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 ++ D L +G+G YG V + + GE VA+K D+ + T E+ Sbjct: 3 QRTVARDITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRET--ELYNTVM 58 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYFIYQTLRA 124 +HENI+ S + ++++I + L+ + L + Sbjct: 59 LRHENILGFI-ASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASG 117 Query: 125 VKVLH--------GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 + LH + HRDLK N+L+ N + D GLA + Sbjct: 118 LAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLA------VMHSQSTNQLD 171 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYS-----RAMDVWSCGCILAELFLRRPIFPGRDYRHQ 231 G V T+ Y APEV+ + + + +D+W+ G +L E+ R Sbjct: 172 VGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMV---------- 221 Query: 232 LLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKM-FPRVNPKGIDLLQRML 290 I P D R+ + P P P + L++ Sbjct: 222 SNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAK-LMKECW 280 Query: 291 VFDPAKRITA 300 +P+ R+TA Sbjct: 281 YQNPSARLTA 290 >2JD5-A nrPDB Length = 373 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 73/337 (21%), Positives = 121/337 (35%), Gaps = 54/337 (16%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHE-- 69 + L LG G + V A VA+K + ++ EIK+L+ Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR--GDKVYTEAAEDEIKLLQRVNDADN 77 Query: 70 ---------NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST---QMLSDDHIQYF 117 +I+ + + N V ++ E++ +L +I + + +++ Sbjct: 78 TKEDSMGANHILKLLDHFNHKGP-NGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQI 136 Query: 118 IYQTLRAVKVLHGS-NVIHRDLKPSNLLI------NSNCDLKVCDFGLARIIDESAADNS 170 Q L + +H +IH D+KP N+L+ + +K+ D G A DE Sbjct: 137 SKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDE------ 190 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF---PGRD 227 T + TR YR+PEV+L A + D+WS C++ EL +F G Sbjct: 191 -------HYTNSIQTREYRSPEVLLG-APWGCGADIWSTACLIFELITGDFLFEPDEGHS 242 Query: 228 YRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVN-------- 279 Y I II R + S + K +P + Sbjct: 243 YTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKF 302 Query: 280 --PKGI---DLLQRMLVFDPAKRITAKEALEHPYLQT 311 + D L ML DP KR A + HP+L+ Sbjct: 303 SKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKD 339 >6CTH-A nrPDB Length = 309 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 57/218 (26%), Positives = 101/218 (46%), Gaps = 22/218 (10%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 ++S+F ++ LGEG +G V + + +A+KK+ K E+KI+ +H Sbjct: 13 VTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYA-SEVKIISRLRH 71 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVI--STQMLSDDHIQYFIYQTLRAV 125 +N++ + E+ ++ E M L I +L+ + + A+ Sbjct: 72 KNLVKLIGWC-----HERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASAL 126 Query: 126 KVLHGSN---VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 LH V+HRD+K SN++++S+ + K+ DFGLAR++D + T Sbjct: 127 LYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKK---------TLL 177 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRR 220 T Y APE + +S K S+ DV+S G + E+ R Sbjct: 178 AGTVGYMAPECL-SSGKASKESDVYSFGVVALEIASGR 214 >3M42-A nrPDB Length = 299 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 73/342 (21%), Positives = 127/342 (37%), Gaps = 75/342 (21%) Query: 9 ISSDFQLKS-LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKIL-KHF 66 I D+++ S +LG G G V +K T E A+K + + RE+++ + Sbjct: 15 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRAS 68 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIST---QMLSDDHIQYFIYQTL 122 + +I+ I ++ + + + I+ E + L I Q ++ + Sbjct: 69 QCPHIVRIVDV-YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 127 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 A++ LH N+ HRD+KP NLL S N LK+ DFG A+ Sbjct: 128 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET----------------- 170 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 T KY ++ D+WS G I+ L P F Y + L I + Sbjct: 171 ----------------TGEKYDKSCDMWSLGVIMYILLCGYPPF----YSNHGLAISPGM 210 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 T R +Y P + V+ + L++ +L +P +R+T Sbjct: 211 KT-----------RIRMGQYEFPNPE---------WSEVSEEVKMLIRNLLKTEPTQRMT 250 Query: 300 AKEALEHPYLQTYHDPNDEP--EGEPIPPSFFEFDHYKEALT 339 E + HP++ P + ++ KE +T Sbjct: 251 ITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMT 292 >5UIU-A nrPDB Length = 323 Score = 180 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 56/228 (24%), Positives = 97/228 (42%), Gaps = 31/228 (13%) Query: 8 NISSDFQL------KSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDK---PLFALRTLR 58 N++++F + +GEG +GVV T VA+KK+ + + Sbjct: 38 NVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQ 95 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIS----TQMLSDDH 113 EIK++ +HEN++ + + +++ ++ M L +S T LS Sbjct: 96 EIKVMAKCQHENLVELLGFSS-----DGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHM 150 Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPT 173 + LH ++ IHRD+K +N+L++ K+ DFGLAR SE Sbjct: 151 RCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARA--------SEKF 202 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRP 221 Q + V T Y APE + + + D++S G +L E+ P Sbjct: 203 AQTVMTSRIVGTTAYMAPEAL--RGEITPKSDIYSFGVVLLEIITGLP 248 >5GRN-A nrPDB Length = 356 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 71/342 (20%), Positives = 119/342 (34%), Gaps = 84/342 (24%) Query: 2 PKRIVYNISSDF-----QLKSLLGEGAYGVVCSATHKPTGE-----IVAIKKIEPFDKPL 51 P ++ Y+ +F L +LG GA+G V T VA+K ++P + Sbjct: 32 PMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSS 91 Query: 52 FALRTLREIKILKHFK-HENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM- 108 + E+KI+ H H NI+ + +YII E DL + Sbjct: 92 EKQALMSELKIMTHLGPHLNIVNLLGACTKS-----GPIYIITEYCFYGDLVNYLHKNRD 146 Query: 109 --------------------------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSN 142 L+ + F YQ R ++ L N +HRDL N Sbjct: 147 SFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARN 206 Query: 143 LLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSR 202 +L+ +K+CDFGLAR I + S+ + ++ +W APE + + Y+ Sbjct: 207 VLLAQGKIVKICDFGLARDIMHDSNYVSKG-------STFLPVKW-MAPESIFDNL-YTT 257 Query: 203 AMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIK 261 DVWS G +L E+F +PG + Y Sbjct: 258 LSDVWSYGILLWEIFSLGGTPYPG-------------------MMVDSTFYNKIKSGYRM 298 Query: 262 SLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 + P + + + ++ + +P KR + Sbjct: 299 AKPDHATSEVYEIMV-----------KCWNSEPEKRPSFYHL 329 >6HV0-A nrPDB Length = 416 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 82/355 (23%), Positives = 141/355 (39%), Gaps = 65/355 (18%) Query: 13 FQLKSLLGEGAYGV-VCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HEN 70 F K +LG GA G V VA+K+I P RE+++L+ H N Sbjct: 10 FCPKDVLGHGAEGTIVYRGMF--DNRDVAVKRILPECFSFAD----REVQLLRESDEHPN 63 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHI--QYFIYQTLRAVKVL 128 +I F ++ F+ YI EL L + + + + + QT + L Sbjct: 64 VIRYFCTEKDRQFQ-----YIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHL 118 Query: 129 HGSNVIHRDLKPSNLLI---NSNCDLK--VCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 H N++HRDLKP N+LI N++ +K + DFGL + + S +G Sbjct: 119 HSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVP------- 171 Query: 184 ATRWYRAPEVMLT--SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 T + APE++ + +D++S GC+ + G+ + Q ++ G Sbjct: 172 GTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACS- 230 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 L C+ + + I +L+++M+ DP KR +AK Sbjct: 231 ------LDCLHPEKHEDVI---------------------ARELIEKMIAMDPQKRPSAK 263 Query: 302 EALEHPYL-------QTYHDPNDEPEGEPIP-PSFFEFDHYKEALTTKDLKKLIW 348 L+HP+ Q + D +D E E + P + + A+ D ++ I Sbjct: 264 HVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENIT 318 >4LRM-A nrPDB Length = 334 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 114/310 (36%), Gaps = 31/310 (10%) Query: 2 PKRIVYNISSD--FQLKSLLGEGAYGVVCSATHKPTGEIV----AIKKIEPFDKPLFALR 55 P + + I + F+ +LG GA+G V P GE V AIK++ P Sbjct: 8 PNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE 67 Query: 56 TLREIKILKHFKHE---NIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDD 112 L E ++ + ++ + I + + ++ L+ + + Sbjct: 68 ILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLD---YVREHKDNIGSQ 124 Query: 113 HIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEP 172 ++ + Q + + L ++HRDL N+L+ + +K+ DFGLA+++ + Sbjct: 125 YLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE 184 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIF---PGRDY 228 G+ V +W A E +L Y+ DVWS G + EL + P + Sbjct: 185 GGK-------VPIKW-MALESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEI 235 Query: 229 RHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQR 288 L + P D+ I S P + +E +P QR Sbjct: 236 SSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDP------QR 289 Query: 289 MLVFDPAKRI 298 LV +R+ Sbjct: 290 YLVIQGDERM 299 >5FM2-A nrPDB Length = 355 Score = 180 bits (457), Expect = 8e-46, Method: Composition-based stats. Identities = 64/314 (20%), Positives = 113/314 (35%), Gaps = 56/314 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATH-----KPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 + L LGEG +G V AT + VA+K ++ P L E +LK Sbjct: 64 KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQ 123 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM---------------- 108 H ++I ++ D + +I E + L + Sbjct: 124 VNHPHVIKLYGACSQD-----GPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS 178 Query: 109 ---------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLA 159 L+ + F +Q + ++ L ++HRDL N+L+ +K+ DFGL+ Sbjct: 179 SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLS 238 Query: 160 RIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL- 218 R + E + G+ + +W A E + Y+ DVWS G +L E+ Sbjct: 239 RDVYEEDSYVKRSQGR-------IPVKW-MAIESLFDHI-YTTQSDVWSFGVLLWEIVTL 289 Query: 219 RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRV 278 +PG +F ++ T H R ++ P +F + Sbjct: 290 GGNPYPGIPPE----RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEP--DKRPVFADI 343 Query: 279 NPKGIDLLQRMLVF 292 + DL ++M+V Sbjct: 344 S---KDL-EKMMVK 353 >3DLS-A nrPDB Length = 335 Score = 180 bits (457), Expect = 8e-46, Method: Composition-based stats. Identities = 66/312 (21%), Positives = 113/312 (36%), Gaps = 64/312 (20%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFAL-------RTLREIKI 62 S + S LG GA+G V +A K + V +K I+ + EI I Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI 82 Query: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLH---RVISTQMLSDDHIQYFIY 119 L +H NII + +I FEN ++ E + L + L + Y Sbjct: 83 LSRVEHANIIKVLDI-----FENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFR 137 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 Q + AV L ++IHRD+K N++I + +K+ DFG A ++ + Sbjct: 138 QLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLE-----------RGKLF 186 Query: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 + T Y APEV++ + +++WS G L L F + I Sbjct: 187 YTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFC-----ELEETVEAAI 241 Query: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 P+ V+ + + L+ +L P +R T Sbjct: 242 HPPYL---------------------------------VSKELMSLVSGLLQPVPERRTT 268 Query: 300 AKEALEHPYLQT 311 ++ + P++ Sbjct: 269 LEKLVTDPWVTQ 280 >3PLS-A nrPDB Length = 298 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 65/290 (22%), Positives = 110/290 (37%), Gaps = 45/290 (15%) Query: 17 SLLGEGAYGVVCSATHKPTGE---IVAIKKIEPFDKPLFALRTLREIKILKHFKHENIIT 73 ++G+G +GVV + + AIK + + LRE +++ H N++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLA 86 Query: 74 IFNIQRPDSFENFNEVYIIQELMQTDLHRVIST--QMLSDDHIQYFIYQTLRAVKVLHGS 131 + I P E V + + DL + I + + + + F Q R ++ L Sbjct: 87 LIGIMLPP--EGLPHVLLP-YMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQ 143 Query: 132 NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 +HRDL N +++ + +KV DFGLAR I + E Q + +W A Sbjct: 144 KFVHRDLAARNCMLDESFTVKVADFGLARDILD-----REYYSVQQHRHARLPVKW-TAL 197 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCI 251 E + T +++ DVWS G +L EL R P+ D + Sbjct: 198 ESLQTY-RFTTKSDVWSFGVLLWELLTRGAP-------------------PYRHIDPFDL 237 Query: 252 ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 A+ P Y L ++ +Q+ DPA R T + Sbjct: 238 THFLAQGRRLPQPEYCPDSLYQV-----------MQQCWEADPAVRPTFR 276 >1U59-A nrPDB Length = 287 Score = 180 bits (456), Expect = 9e-46, Method: Composition-based stats. Identities = 49/258 (18%), Positives = 104/258 (40%), Gaps = 23/258 (8%) Query: 18 LLGEGAYGVVCSATHKPTGEI--VAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIF 75 LG G +G V ++ + VAIK ++ + +RE +I+ + I+ + Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 76 Query: 76 NIQRPDSFENFNEVYIIQELMQTD-LHRVI--STQMLSDDHIQYFIYQTLRAVKVLHGSN 132 + + ++ + ++ E+ LH+ + + + ++ ++Q +K L N Sbjct: 77 GVCQAEA------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 130 Query: 133 VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPE 192 +HRDL N+L+ + K+ DFGL++ + + + + + + +WY APE Sbjct: 131 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL------KWY-APE 183 Query: 193 VMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIF---GIIGTPHSDNDL 248 + K+S DVWS G + E + + + I + P +L Sbjct: 184 CI-NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL 242 Query: 249 RCIESPRAREYIKSLPMY 266 + S + P + Sbjct: 243 YALMSDCWIYKWEDRPDF 260 >1LUF-A nrPDB Length = 343 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 54/259 (20%), Positives = 96/259 (37%), Gaps = 50/259 (19%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGE-------IVAIKKIEPFDKPLFALRTLREIKIL 63 ++ + +GEGA+G V A G +VA+K ++ RE ++ Sbjct: 47 NNIEYVRDIGEGAFGRVFQAR--APGLLPYEPFTMVAVKMLKEEASADMQADFQREAALM 104 Query: 64 KHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVIST---------------- 106 F + NI+ + + + ++ E M DL+ + + Sbjct: 105 AEFDNPNIVKLLGVCAVG-----KPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLST 159 Query: 107 ---------QMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFG 157 LS Q + L +HRDL N L+ N +K+ DFG Sbjct: 160 RARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFG 219 Query: 158 LARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 L+R I +AD + G + + RW PE + + +Y+ DVW+ G +L E+F Sbjct: 220 LSRNI--YSADYYKADGNDA-----IPIRW-MPPESIFYN-RYTTESDVWAYGVVLWEIF 270 Query: 218 L-RRPIFPGRDYRHQLLLI 235 + G + + + Sbjct: 271 SYGLQPYYGMAHEEVIYYV 289 >3QD2-B nrPDB Length = 332 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 75/337 (22%), Positives = 127/337 (37%), Gaps = 75/337 (22%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 +DF+ +G G +GVV A +K AIK+I ++ L + +RE+K L +H Sbjct: 6 TDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 65 Query: 71 IITIFN----------------------------------------IQRPDSFENFN--- 87 I+ FN I+R D F N Sbjct: 66 IVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVG 125 Query: 88 ---------EVYIIQELMQT-DLHRVISTQMLSDDH----IQYFIYQTLRAVKVLHGSNV 133 +YI +L + +L ++ + +D + Q AV+ LH + Sbjct: 126 QLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGL 185 Query: 134 IHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS--EPTGQQSGMTEYVATRWYRAP 191 +HRDLKPSN+ + +KV DFGL +D+ + + P + T V T+ Y +P Sbjct: 186 MHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSP 245 Query: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCI 251 E + YS +D++S G IL EL + ++ +I D+R + Sbjct: 246 EQI-HGNNYSHKVDIFSLGLILFELL-----YSFSTQMERVRII----------TDVRNL 289 Query: 252 ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQR 288 + P + P P+ D+++ Sbjct: 290 KFPLLFTQKYPQEHMMVQDMLSPSPTERPEATDIIEN 326 >2OZO-A nrPDB Length = 613 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 48/258 (18%), Positives = 104/258 (40%), Gaps = 23/258 (8%) Query: 18 LLGEGAYGVVCSATHKPTGEI--VAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIF 75 LG G +G V ++ + VAIK ++ + +RE +I+ + I+ + Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 Query: 76 NIQRPDSFENFNEVYIIQELMQTD-LHRVI--STQMLSDDHIQYFIYQTLRAVKVLHGSN 132 + + ++ + ++ E+ LH+ + + + ++ ++Q +K L N Sbjct: 403 GVCQAEA------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 Query: 133 VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPE 192 +HR+L N+L+ + K+ DFGL++ + + + + + + +WY APE Sbjct: 457 FVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL------KWY-APE 509 Query: 193 VMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIF---GIIGTPHSDNDL 248 + K+S DVWS G + E + + + I + P +L Sbjct: 510 CI-NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL 568 Query: 249 RCIESPRAREYIKSLPMY 266 + S + P + Sbjct: 569 YALMSDCWIYKWEDRPDF 586 >3C1X-A nrPDB Length = 373 Score = 178 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 56/280 (20%), Positives = 104/280 (37%), Gaps = 20/280 (7%) Query: 14 QLKSLLGEGAYGVVCSATHKP-TGEIV--AIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 ++G G +G V T G+ + A+K + + L E I+K F H N Sbjct: 92 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 151 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIS--TQMLSDDHIQYFIYQTLRAVKV 127 ++++ I ++ M DL I T + + F Q + +K Sbjct: 152 VLSLLGICLRS----EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKF 207 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 L +HRDL N +++ +KV DFGLAR + + D + + +W Sbjct: 208 LASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFD-----SVHNKTGAKLPVKW 262 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 A E + + K++ DVWS G +L EL P +P + + + + Sbjct: 263 -MALESL-QTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEY 320 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLL 286 + + + M P+ ++ R++ + Sbjct: 321 CPDPLYEVMLKCWHPKAEMRPS--FSELVSRISAIFSTFI 358 >5HLW-A nrPDB Length = 299 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 56/280 (20%), Positives = 104/280 (37%), Gaps = 20/280 (7%) Query: 14 QLKSLLGEGAYGVVCSATHKP-TGEIV--AIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 ++G G +G V T G+ + A+K + + L E I+K F H N Sbjct: 23 HFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPN 82 Query: 71 IITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIS--TQMLSDDHIQYFIYQTLRAVKV 127 ++++ I ++ M DL I T + + F Q + +K Sbjct: 83 VLSLLGICLRS----EGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKY 138 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 L +HRDL N +++ +KV DFGLAR + + E + + +W Sbjct: 139 LASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHD-----KEYYSVHNKTGAKLPVKW 193 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 A E + + K++ DVWS G +L EL P +P + + + + Sbjct: 194 -MALESL-QTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEY 251 Query: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLL 286 + + + M P+ ++ R++ + Sbjct: 252 CPDPLYEVMLKCWHPKAEMRPS--FSELVSRISAIFSTFI 289 >4YFF-A nrPDB Length = 311 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 49/220 (22%), Positives = 83/220 (37%), Gaps = 22/220 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKH 68 S+ + ++G G++G V + +IVAIK+ RE+ IL H Sbjct: 42 SEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNH 99 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM--LSDDHIQYFIYQTLRAV 125 +I + ++ I+ + + L ++ Q L + + Sbjct: 100 PCVIQFVGAC----LNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGM 155 Query: 126 KVLHG--SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 + LH +IHRDL N+L+ + V DFG +R + DN MT+ Sbjct: 156 EYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDN---------MTKQP 206 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 + APEV +Y+ DV+S L E+ F Sbjct: 207 GNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPF 246 >2RIO-A nrPDB Length = 434 Score = 177 bits (450), Expect = 4e-45, Method: Composition-based stats. Identities = 79/324 (24%), Positives = 137/324 (42%), Gaps = 74/324 (22%) Query: 16 KSLLGEGAYG-VVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HENIIT 73 + +LG G+ G VV + + G VA+K++ F L EIK+L H N+I Sbjct: 20 EKILGYGSSGTVVFQGSFQ--GRPVAVKRM----LIDFCDIALMEIKLLTESDDHPNVIR 73 Query: 74 IFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQ--------YFIYQTLRAV 125 + + D F +YI EL +L ++ ++ +SD++++ + Q V Sbjct: 74 YYCSETTDRF-----LYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGV 128 Query: 126 KVLHGSNVIHRDLKPSNLLIN-------------SNCDLKVCDFGLARIIDESAADNSEP 172 LH +IHRDLKP N+L++ N + + DFGL + +D + Sbjct: 129 AHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTN 188 Query: 173 TGQQSGMTEYVATRWYRAPEV------MLTSAKYSRAMDVWSCGCILAELFL-RRPIFPG 225 S T +RAPE+ + T + +R++D++S GC+ + + F G Sbjct: 189 LNNPS------GTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF-G 241 Query: 226 RDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDL 285 Y + +I GI S ++++C+ + + DL Sbjct: 242 DKYSRESNIIRGI----FSLDEMKCLHDR----------------------SLIAEATDL 275 Query: 286 LQRMLVFDPAKRITAKEALEHPYL 309 + +M+ DP KR TA + L HP Sbjct: 276 ISQMIDHDPLKRPTAMKVLRHPLF 299 >3QUP-A nrPDB Length = 323 Score = 177 bits (450), Expect = 5e-45, Method: Composition-based stats. Identities = 60/307 (19%), Positives = 103/307 (33%), Gaps = 54/307 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTG---EIVAIKKIEPFD-KPLFALRTLREIKILKHF 66 F L +LG+G +G V A K VA+K ++ LRE +K F Sbjct: 23 QQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEF 82 Query: 67 KHENIITIFNIQRPDSFENFNEV-YIIQELM-QTDLHRVISTQM-------LSDDHIQYF 117 H ++ + + + + +I M DLH + L + F Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRF 142 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 + ++ L N IHRDL N ++ + + V DFGL+R I + Sbjct: 143 MVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDY-------YRQ 195 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIF 236 G + +W A E + + Y+ DVW+ G + E+ + + G + + Sbjct: 196 GCASKLPVKW-LALESLADNL-YTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYL- 252 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAK 296 IG C+E + DL+ + DP + Sbjct: 253 --IGGNRLKQPPECME----------------------------EVYDLMYQCWSADPKQ 282 Query: 297 RITAKEA 303 R + Sbjct: 283 RPSFTCL 289 >4Y93-A nrPDB Length = 446 Score = 177 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 50/237 (21%), Positives = 93/237 (39%), Gaps = 24/237 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEI-VAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 D LG G +GVV + G+ VAIK I+ + + + E K++ + HE Sbjct: 188 KDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIK--EGSMSEDEFIEEAKVMMNLSHE 243 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIS--TQMLSDDHIQYFIYQTLRAVK 126 ++ ++ + ++II E M L + + A++ Sbjct: 244 KLVQLYGVCTKQ-----RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAME 298 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L +HRDL N L+N +KV DFG+ R + + +S + Sbjct: 299 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSS--------TGSKFPVK 350 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTP 242 W +PEV++ +K+S D+W+ G ++ E++ + + I + P Sbjct: 351 W-ASPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLP 405 >3ZBF-A nrPDB Length = 322 Score = 177 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 68/335 (20%), Positives = 116/335 (34%), Gaps = 72/335 (21%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKP-----TGEI-VAIKKIEPFDKPLFALRTLREIKILK 64 L+ LLG GA+G V T +GEI VA+K ++ + L+E ++ Sbjct: 33 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS 92 Query: 65 HFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLS--------DDHIQ 115 F H NI+ + + + YII ELM+ DL + ++ + Sbjct: 93 KFNHPNILKQLGVCLLNEPQ-----YIILELMEGGDLLTYLRKARMATFYGPLLTLVDLV 147 Query: 116 YFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN-----SNCDLKVCDFGLARIIDESAADNS 170 + L + IHRDL N L++ S +K+ DFGLAR I ++ Sbjct: 148 DLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK 207 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYR 229 G + RW APE ++ ++ DVWS G ++ E+ +P Sbjct: 208 RGEG-------LLPVRW-MAPESLMDGI-FTTQSDVWSFGILIWEILTLGHQPYPAHSNL 258 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 L + N + + L+ + Sbjct: 259 DVLNYVQTGGRLEPPRNCPDDLWN-------------------------------LMTQC 287 Query: 290 LVFDPAKRITAK------EALEHPYLQTYHDPNDE 318 +P +R T + + +L + + DE Sbjct: 288 WAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDE 322 >3MDY-A nrPDB Length = 337 Score = 177 bits (448), Expect = 8e-45, Method: Composition-based stats. Identities = 70/314 (22%), Positives = 121/314 (38%), Gaps = 35/314 (11%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 +P + I+ Q+ +G+G YG V + GE VA+K ++ + T EI Sbjct: 27 LPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRET--EI 82 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYFIY 119 +HENI+ + ++ ++Y+I + + L+ + + L + Y Sbjct: 83 YQTVLMRHENILGFIAADIKGT-GSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAY 141 Query: 120 QTLRAVKVLHGS--------NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSE 171 ++ + LH + HRDLK N+L+ N + D GLA + Sbjct: 142 SSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDI 201 Query: 172 PTGQQSGMTEYVATRWYRAPEVMLTSAKYSR-----AMDVWSCGCILAELFLRRPIFPGR 226 P + V T+ Y PEV+ S + D++S G IL E+ RR + G Sbjct: 202 PPNTR------VGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVA-RRCVSGGI 254 Query: 227 DYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLL 286 +QL + P ++ + + R P +P R K L+ Sbjct: 255 VEEYQLPYHDLVPSDPSYEDMREIVCIKKLR------PSFPNRWSSDECLRQMGK---LM 305 Query: 287 QRMLVFDPAKRITA 300 +PA R+TA Sbjct: 306 TECWAHNPASRLTA 319 >4XI2-A nrPDB Length = 446 Score = 177 bits (448), Expect = 8e-45, Method: Composition-based stats. Identities = 51/234 (21%), Positives = 92/234 (39%), Gaps = 24/234 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEI-VAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 D LG G +GVV + G+ VAIK I + + + E K++ + HE Sbjct: 187 KDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIR--EGSMSEDEFIEEAKVMMNLSHE 242 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIS--TQMLSDDHIQYFIYQTLRAVK 126 ++ ++ + ++II E M L + + A++ Sbjct: 243 KLVQLYGVCTKQ-----RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAME 297 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L +HRDL N L+N +KV DFGL+R + + +S + R Sbjct: 298 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSS--------VGSKFPVR 349 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGII 239 W PEV++ +K+S D+W+ G ++ E++ + + I + Sbjct: 350 W-SPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGL 401 >5TOS-A nrPDB Length = 395 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 62/311 (19%), Positives = 112/311 (36%), Gaps = 46/311 (14%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKP---------TGEIVAIKKIEPFDKPLFALRTLREI 60 + +F+ S++GEG +G V TG ++A+KK+ L EI Sbjct: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEI 122 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM-----LSDDHI 114 L H N++ + D ++ E M + L + + L Sbjct: 123 NYLGQLSHPNLVKLIGYCLEDEHR-----LLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 Query: 115 QYFIYQTLRAVKVLHGS--NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEP 172 + + LH VI+RD+K SN+L++++ + K+ DFGLAR Sbjct: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS- 236 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 T + T Y APE ++S + DV+S G +L E+ + + Sbjct: 237 -------TRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEE 288 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 L+ + R + + + + L + R+ + + L F Sbjct: 289 NLV----------DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV----QCLSF 334 Query: 293 DPAKRITAKEA 303 +P R T + Sbjct: 335 EPKSRPTMDQV 345 >1AD5-A nrPDB Length = 438 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 58/261 (22%), Positives = 105/261 (40%), Gaps = 34/261 (13%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 +L+ LG G +G V AT+ + VA+K ++P + A L E ++K +H+ ++ Sbjct: 184 LKLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMSVEA--FLAEANVMKTLQHDKLV 240 Query: 73 TIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQ---MLSDDHIQYFIYQTLRAVKVL 128 + + + +YII E M + L + + + F Q + + Sbjct: 241 KLHAVVTKE------PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFI 294 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 N IHRDL+ +N+L++++ K+ DFGLAR+ +W Sbjct: 295 EQRNYIHRDLRAANILVSASLVCKIADFGLARV------------------GAKFPIKW- 335 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 APE + ++ DVWS G +L E+ R +PG + + P +N Sbjct: 336 TAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENC 394 Query: 248 LRCIESPRAREYIKSLPMYPA 268 + + R + P Sbjct: 395 PEELYNIMMRCWKNRPEERPT 415 >6E4F-A nrPDB Length = 290 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 51/234 (21%), Positives = 93/234 (39%), Gaps = 24/234 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEI-VAIKKIEPFDKPLFALRTLREIKILKHFKHE 69 D LG G +GVV + G+ VAIK I+ + + + E K++ + HE Sbjct: 31 KDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIK--EGSMSEDEFIEEAKVMMNLSHE 86 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVIS--TQMLSDDHIQYFIYQTLRAVK 126 ++ ++ + ++II E M L + + A++ Sbjct: 87 KLVQLYGVCTKQ-----RPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAME 141 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 L +HRDL N L+N +KV DFGL+R + + +S + R Sbjct: 142 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSS--------VGSKFPVR 193 Query: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGII 239 W PEV++ +K+S D+W+ G ++ E++ + + I + Sbjct: 194 W-SPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGL 245 >5VD3-A nrPDB Length = 311 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 112/310 (36%), Gaps = 55/310 (17%) Query: 2 PKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKK-IEPFDKPLFALRTLREI 60 P R FQ S LG G+YG V K G + A+K+ + PF P R L E+ Sbjct: 48 PSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEV 107 Query: 61 KILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM--LSDDHIQYF 117 + +H + + ++E +Y+ EL L + L + + + Sbjct: 108 GSHEKVGQHPCCVRL-----EQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGY 162 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 + TL A+ LH ++H D+KP+N+ + K+ DFGL + + A + Sbjct: 163 LRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQE----- 217 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 Y APE++ S Y A DV+S G + E+ + G + QL Sbjct: 218 ------GDPRYMAPELLQGS--YGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ--- 266 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 + ++ + +L ML DP R Sbjct: 267 ------------------------------GYLPPEFTAGLSSELRSVLVMMLEPDPKLR 296 Query: 298 ITAKEALEHP 307 TA+ L P Sbjct: 297 ATAEALLALP 306 >4Y83-A nrPDB Length = 332 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 72/310 (23%), Positives = 118/310 (38%), Gaps = 56/310 (18%) Query: 1 MPKRIVY-NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLRE 59 +P ++ Y NI SDF + GA+G V A T + +A K I Sbjct: 67 IPWKLTYRNIGSDF-----IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD------ 115 Query: 60 IKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD--LHRVISTQMLSDDHIQYF 117 ++I F+HENI ++ + V++ E + L ++ S + + I + Sbjct: 116 VEIQACFRHENIAELYG-----AVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWV 170 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 L+ + LH VIH D+KPSN++ S + + DFGL+ + E + Sbjct: 171 TKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLR---- 225 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 T Y +PEV+L +S D++S G L + P + R R Sbjct: 226 ------GTEIYMSPEVILCRG-HSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLY 278 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 II A PLE + +P +L++ L +P R Sbjct: 279 II-------------------------HKQAPPLEDIADDCSPGMRELIEASLERNPNHR 313 Query: 298 ITAKEALEHP 307 A + L+H Sbjct: 314 PRAADLLKHE 323 >2A1A-B nrPDB Length = 284 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 63/316 (19%), Positives = 103/316 (32%), Gaps = 68/316 (21%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILK 64 + DF+ L+G G +G V A H+ G+ IK+++ + + RE+K L Sbjct: 5 VDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-----EKAEREVKALA 59 Query: 65 HFKHENIITIFNIQRPDSFENFNE-----------VYIIQELMQ-TDLHRVISTQM---L 109 H NI+ ++ ++I E L + I + L Sbjct: 60 KLDHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKL 119 Query: 110 SDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADN 169 Q + V +H +I+RDLKPSN+ + +K+ DFGL + Sbjct: 120 DKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRT 179 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 T Y +PE + +S Y + +D+++ G ILAEL Sbjct: 180 RSK-----------GTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL------------ 215 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 + T + I LLQ++ Sbjct: 216 -------HVCDTAFETSKFFTDLRDGIISDIFDKKEKT-----------------LLQKL 251 Query: 290 LVFDPAKRITAKEALE 305 L P R E L Sbjct: 252 LSKKPEDRPNTSEILR 267 >3I81-A nrPDB Length = 315 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 55/311 (17%), Positives = 106/311 (34%), Gaps = 63/311 (20%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGE-----IVAIKKIEPFDKPLFALRTLREIKILKH 65 + LG+G++G+V K + VAIK + + L E ++K Sbjct: 18 EKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKE 77 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIST--------QMLSDDHIQY 116 F +++ + + +I ELM + DL + + +L+ + Sbjct: 78 FNCHHVVRLLGVVSQG-----QPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSK 132 Query: 117 FIY---QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPT 173 I + + L+ + +HRDL N ++ + +K+ DFG+ R I E+ Sbjct: 133 MIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDY------ 186 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQL 232 + G + RW +PE + ++ DVWS G +L E+ + G L Sbjct: 187 -YRKGGKGLLPVRW-MSPESL-KDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVL 243 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 + DN + +L++ + Sbjct: 244 RFVMEGGLLDKPDNCPDML-------------------------------FELMRMCWQY 272 Query: 293 DPAKRITAKEA 303 +P R + E Sbjct: 273 NPKMRPSFLEI 283 >3SXS-A nrPDB Length = 268 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 51/232 (21%), Positives = 92/232 (39%), Gaps = 28/232 (12%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 + L LG G +GVV K + VA+K I+ + + +E + + H Sbjct: 8 EEITLLKELGSGQFGVVKLGKWKGQYD-VAVKMIK--EGSMSEDEFFQEAQTMMKLSHPK 64 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVISTQM--LSDDHIQYFIYQTLRAVKV 127 ++ + + + +YI+ E + L + + L + Y + Sbjct: 65 LVKFYGVCSKE-----YPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAF 119 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 L IHRDL N L++ + +KV DFG+ R + + +S V T++ Sbjct: 120 LESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSS------------VGTKF 167 Query: 188 ---YRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLI 235 + APEV KYS DVW+ G ++ E+F + + +L + Sbjct: 168 PVKWSAPEV-FHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKV 218 >3G2F-A nrPDB Length = 336 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 63/314 (20%), Positives = 116/314 (36%), Gaps = 34/314 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILK--HFKH 68 + +L L+G G YG V + VA+K ++ + E I + +H Sbjct: 13 DNLKLLELIGRGRYGAVYKGS--LDERPVAVKVFSFANRQN----FINEKNIYRVPLMEH 66 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 +NI + + E ++ E L + +S + R + Sbjct: 67 DNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAY 126 Query: 128 LHGS---------NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 LH + HRDL N+L+ ++ + DFGL+ + + P + + Sbjct: 127 LHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLS--MRLTGNRLVRPGEEDNA 184 Query: 179 MTEYVATRWYRAPEVMLTSAKYS------RAMDVWSCGCILAELFLRRP-IFPGRDYRHQ 231 V T Y APEV+ + + +D+++ G I E+F+R +FPG Sbjct: 185 AISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEY 244 Query: 232 LLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLV 291 + +G + D++ + S K P +P A E + + ++ Sbjct: 245 QMAFQTEVGNHPTFEDMQVLVSRE-----KQRPKFPEAWKENSLAVRS--LKETIEDCWD 297 Query: 292 FDPAKRITAKEALE 305 D R+TA+ A E Sbjct: 298 QDAEARLTAQCAEE 311 >5WNL-A nrPDB Length = 342 Score = 173 bits (440), Expect = 7e-44, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 118/299 (39%), Gaps = 43/299 (14%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKH 68 + +F +G G +G V H +AIK + L E K ++ K Sbjct: 19 AGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKF 78 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 I+ ++ I + V ++ E M+ L ++++++ L D +++T + Sbjct: 79 RYILPVYGICQE-------PVGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNF 131 Query: 128 LHGSN--VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 LH + ++H +LKP+N+L++++ +K+ DFGLA+ N M T Sbjct: 132 LHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKC-------NGMSHSHDLSMDGLFGT 184 Query: 186 RWYRAPEVMLTSAK-YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 Y PE + ++ + DV+S ++ + ++ F D ++ L ++ ++ Sbjct: 185 IAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPF--ADEKNILHIMMKVVKGHRP 242 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 + C + PR I L+QR DP R T +E Sbjct: 243 ELPPIC----------------------RPRPRACASLIGLMQRCWHADPQVRPTFQEI 279 >4HZS-A nrPDB Length = 341 Score = 173 bits (439), Expect = 9e-44, Method: Composition-based stats. Identities = 53/234 (22%), Positives = 94/234 (40%), Gaps = 23/234 (9%) Query: 11 SDFQLKSLLGEGAYGVVCSATH-KPTGEIV--AIKKIEPF--DKPLFALRTLREIKILKH 65 D +L LG+G++GVV P+G+ V A+K ++P +P +RE+ + Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 71 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM--LSDDHIQYFIYQTL 122 H N+I ++ + + ++ EL L + + + Q Sbjct: 72 LDHRNLIRLYGVVLTPPMK------MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVA 125 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + L IHRDL NLL+ + +K+ DFGL R + ++ ++ Sbjct: 126 EGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRK------ 179 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLI 235 + APE + + +S A D W G L E+F + + G + L I Sbjct: 180 -VPFAWCAPESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKI 231 >5U6C-A nrPDB Length = 315 Score = 173 bits (439), Expect = 9e-44, Method: Composition-based stats. Identities = 52/255 (20%), Positives = 91/255 (35%), Gaps = 22/255 (8%) Query: 15 LKSLLGEGAYGVVCSATHKP---TGEIVAIKKIEP-FDKPLFALRTLREIKILKHFKHEN 70 L +LGEG +G V K T VA+K ++ L E +K F H N Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPN 99 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQML-------SDDHIQYFIYQTL 122 ++ + + S + + +I M+ DLH + L + F+ Sbjct: 100 VMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIA 159 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 ++ L N +HRDL N ++ + + V DFGL++ I + G Sbjct: 160 LGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDY-------YRQGRIAK 212 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGT 241 + +W A E + Y+ DVW+ G + E+ +PG + Sbjct: 213 MPVKW-IAIESLADRV-YTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRL 270 Query: 242 PHSDNDLRCIESPRA 256 ++ L + Sbjct: 271 KQPEDCLDELYEIMY 285 >5XD6-A nrPDB Length = 305 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 66/272 (24%), Positives = 111/272 (40%), Gaps = 29/272 (10%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 +P + +I+ ++ KSL+GEG+YG V K +G+ AIKK++ +P L ++ Sbjct: 12 IPADELRDITDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPDQ--EFLAQV 68 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM----------LS 110 ++ + EN++ + Y LH ++ + LS Sbjct: 69 SMVSRLRQENVVALLGYCVDGPLRVLAYEYAP----NGSLHDILHGRKGVKGAQPGPVLS 124 Query: 111 DDHIQYFIYQTLRAVKVLHGS---NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAA 167 R ++ LH +VIHRD+K SN+L+ + K+ DF L+ + AA Sbjct: 125 WHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAA 184 Query: 168 DNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 + T + T Y APE +T S DV+S G +L EL R Sbjct: 185 --------RLHSTRVLGTFGYHAPEYAMT-GTLSTKSDVYSFGVVLLELLTGRKPVDHTL 235 Query: 228 YRHQLLLIFGIIGTPHSDNDLRCIESPRAREY 259 R Q ++ D +C+++ EY Sbjct: 236 PRGQQSVVTWATPKLSEDKVKQCVDARLNGEY 267 >1U54-B nrPDB Length = 291 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 53/234 (22%), Positives = 94/234 (40%), Gaps = 23/234 (9%) Query: 11 SDFQLKSLLGEGAYGVVCSATH-KPTGEIV--AIKKIEPF--DKPLFALRTLREIKILKH 65 D +L LG+G++GVV P+G+ V A+K ++P +P +RE+ + Sbjct: 18 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 77 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM--LSDDHIQYFIYQTL 122 H N+I ++ + + ++ EL L + + + Q Sbjct: 78 LDHRNLIRLYGVVLTPPMK------MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVA 131 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 + L IHRDL NLL+ + +K+ DFGL R + ++ ++ Sbjct: 132 EGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRK------ 185 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLI 235 + APE + + +S A D W G L E+F + + G + L I Sbjct: 186 -VPFAWCAPESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKI 237 >6J5U-C nrPDB Length = 426 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 65/311 (20%), Positives = 114/311 (36%), Gaps = 42/311 (13%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPT---------GEIVAIKKIEPFDKPLFALRTLR 58 N + +F+ +LLGEG +G V T G +VA+K+++P + L Sbjct: 81 NATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKP-EGFQGHKEWLT 139 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI---STQMLSDDHIQ 115 E+ L H N++ + E N + + + + + L + Q L+ Sbjct: 140 EVNYLGQLSHPNLVLLVGYCA----EGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRM 195 Query: 116 YFIYQTLRAVKVLHGSN--VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPT 173 + + LH + VI+RD K +N+L++++ + K+ DFGLA+ Sbjct: 196 KVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKA--------GPTG 247 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLL 233 T+ + T Y APE + + + + DV+S G +L EL R D + Sbjct: 248 DNTHVSTKVIGTHGYAAPE-YVATGRLTAKSDVYSFGVVLLELISGR---RAMDNSNGGN 303 Query: 234 LIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFD 293 + D R + + P A +L + L D Sbjct: 304 EYSLVDWATPYLGDKRKLFRIMDTKLGGQYPQKGAF-----------TAANLALQCLNPD 352 Query: 294 PAKRITAKEAL 304 R E L Sbjct: 353 AKLRPKMSEVL 363 >3MY0-A nrPDB Length = 305 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 64/309 (20%), Positives = 107/309 (34%), Gaps = 35/309 (11%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 ++ L +G+G YG V GE VA+K D+ + T EI Sbjct: 3 QRTVARQVALVECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFRET--EIYNTVL 58 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYFIYQTLRA 124 +H+NI+ S + ++++I + L+ + Q L Sbjct: 59 LRHDNILGFI-ASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACG 117 Query: 125 VKVLH--------GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 + LH + HRD K N+L+ SN + D GLA + + + Sbjct: 118 LAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDI----- 172 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYS-----RAMDVWSCGCILAELFLRRPIFPGRDYRHQ 231 G V T+ Y APEV+ + + D+W+ G +L E+ RR I G Sbjct: 173 -GNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA-RRTIVNG------ 224 Query: 232 LLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLV 291 I P D ++ + P P V +++ Sbjct: 225 ---IVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWY 281 Query: 292 FDPAKRITA 300 +P+ R+TA Sbjct: 282 PNPSARLTA 290 >3UIU-A nrPDB Length = 306 Score = 170 bits (432), Expect = 6e-43, Method: Composition-based stats. Identities = 66/329 (20%), Positives = 106/329 (32%), Gaps = 81/329 (24%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILK 64 + DF+ L+G G +G V A H+ G+ I++++ + + RE+K L Sbjct: 6 VDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNN-----EKAEREVKALA 60 Query: 65 HFKHENIITIFNIQ---------RPDSFENFNE---------------VYIIQELMQ-TD 99 H NI+ DS E+ + ++I E Sbjct: 61 KLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGT 120 Query: 100 LHRVISTQM---LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDF 156 L + I + L Q + V +H +IHRDLKPSN+ + +K+ DF Sbjct: 121 LEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDF 180 Query: 157 GLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216 GL + T Y +PE + +S Y + +D+++ G ILAEL Sbjct: 181 GLVTSLKNDGKRTRSK-----------GTLRYMSPEQI-SSQDYGKEVDLYALGLILAEL 228 Query: 217 FLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFP 276 + T + I Sbjct: 229 L-------------------HVCDTAFETSKFFTDLRDGIISDIFDKKEKT--------- 260 Query: 277 RVNPKGIDLLQRMLVFDPAKRITAKEALE 305 LLQ++L P R E L Sbjct: 261 --------LLQKLLSKKPEDRPNTSEILR 281 >3AOX-A nrPDB Length = 344 Score = 170 bits (432), Expect = 6e-43, Method: Composition-based stats. Identities = 54/294 (18%), Positives = 101/294 (34%), Gaps = 33/294 (11%) Query: 11 SDFQLKSLLGEGAYGVVCSAT-----HKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 + L LG GA+G V + P+ VA+K + L L E I+ Sbjct: 47 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK 106 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM--------LSDDHIQYF 117 F H+NI+ + S ++ +++ + DL + L+ + + Sbjct: 107 FNHQNIVRCIGV----SLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHV 162 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCD---LKVCDFGLARIIDESAADNSEPTG 174 + L ++ IHRD+ N L+ K+ DFG+AR I + Sbjct: 163 ARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI-------YRASY 215 Query: 175 QQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLL 233 + G + +W PE + ++ D WS G +L E+F +P + + L Sbjct: 216 YRKGGCAMLPVKW-MPPEAFMEGI-FTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLE 273 Query: 234 LIFGIIGTPHSDNDLRCIESPR---AREYIKSLPMYPAAPLEKMFPRVNPKGID 284 + N + + + P + + +P I+ Sbjct: 274 FVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVIN 327 >1PY5-A nrPDB Length = 326 Score = 170 bits (431), Expect = 8e-43, Method: Composition-based stats. Identities = 62/316 (19%), Positives = 118/316 (37%), Gaps = 39/316 (12%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 +P + I+ L+ +G+G +G V + GE VA+K ++ RE Sbjct: 19 LPLLVQRTIARTIVLQESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERS----WFREA 72 Query: 61 KILK--HFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYF 117 +I + +HENI+ D+ + +++++ + + L ++ ++ + + Sbjct: 73 EIYQTVMLRHENILGFIAADNKDN-GTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKL 131 Query: 118 IYQTLRAVKVLH--------GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADN 169 T + LH + HRDLK N+L+ N + D GLA D + Sbjct: 132 ALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTI 191 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTS---AKYS--RAMDVWSCGCILAELFLRRPIFP 224 + V T+ Y APEV+ S + + D+++ G + E+ R I Sbjct: 192 DIAPNHR------VGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-G 244 Query: 225 GRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGID 284 G +QL P+ D R+ + + P P Sbjct: 245 GIHEDYQL---------PYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAK 295 Query: 285 LLQRMLVFDPAKRITA 300 +++ + A R+TA Sbjct: 296 IMRECWYANGAARLTA 311 >4IDT-A nrPDB Length = 356 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 68/317 (21%), Positives = 116/317 (36%), Gaps = 62/317 (19%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 LG G++G V K TG A+KK+ +F E+ I+ ++ Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRL---EVFRAE---ELMACAGLTSPRIVPLYGAV 135 Query: 79 RPDSFENFNEVYIIQELMQTD-LHRVISTQM-LSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 R + N I EL++ L +++ Q L +D Y++ Q L ++ LH ++H Sbjct: 136 REGPWVN-----IFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHG 190 Query: 137 DLKPSNLLINSNC-DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVML 195 D+K N+L++S+ +CDFG A + TG T + APEV+L Sbjct: 191 DVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIP-----GTETHMAPEVVL 245 Query: 196 TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPR 255 + +DVWS C++ + + P Sbjct: 246 GRSC-DAKVDVWSSCCMMLHMLNGCHP------------------------WTQFFRGPL 280 Query: 256 AREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA------------ 303 + P P+ ++ P P +Q L +P R++A E Sbjct: 281 CLKIASEPP-----PVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVG 335 Query: 304 -LEHPYLQTYHDPNDEP 319 L+ P+ Y +P P Sbjct: 336 GLKSPWRGEYKEPRHPP 352 >4F9B-A nrPDB Length = 361 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 82/354 (23%), Positives = 143/354 (40%), Gaps = 57/354 (16%) Query: 5 IVYNISSDFQLKSLLGEGAYGVVCSATHK---PTGEIVAIKKIEPFDKPLFALRTLREIK 61 V +S+ F+++ +GEG + V AT + E +A+K + P P +R E++ Sbjct: 15 AVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP---IRIAAELQ 71 Query: 62 ILKHFK-HENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQMLSDDHIQYFIY 119 L +N++ + F + V I ++ ++++ LS ++ ++ Sbjct: 72 CLTVAGGQDNVMGV-----KYCFRKNDHVVIAMPYLEHESFLDILNS--LSFQEVREYML 124 Query: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSN-CDLKVCDFGLARIIDESAADN--------- 169 +A+K +H ++HRD+KPSN L N + DFGLA+ ++ + Sbjct: 125 NLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQ 184 Query: 170 ---------SEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRR 220 S ++ + T +RAPEV+ + A+D+WS G I L R Sbjct: 185 QERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGR 244 Query: 221 PIFP-GRDYRHQLLLIFGIIGTPHSDNDLRCIES-----------------PRAREYIKS 262 F D L I I G+ + + R R S Sbjct: 245 YPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSS 304 Query: 263 LPMYPA-----APLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQT 311 P + A + + V + DLL ++L +PA RITA+EAL HP+ + Sbjct: 305 TPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKD 358 >3SOC-A nrPDB Length = 322 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 114/310 (36%), Gaps = 37/310 (11%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 +Y S QL + G +G V A E VA+K DK + E+ L Sbjct: 19 LYFQSMPLQLLEVKARGRFGCVWKAQ--LLNEYVAVKIFPIQDKQSWQNEY--EVYSLPG 74 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYFIYQTLRA 124 KHENI+ ++ + + + +++I + L + ++S + + + R Sbjct: 75 MKHENILQFIGAEKRGTSVDVD-LWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARG 133 Query: 125 VKVLHG----------SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTG 174 + LH + HRD+K N+L+ +N + DFGLA + + Sbjct: 134 LAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD---- 189 Query: 175 QQSGMTEYVATRWYRAPEVMLTSAKYSR----AMDVWSCGCILAELFLRRPIFPGRDYRH 230 V TR Y APEV+ + + R +D+++ G +L EL R G + Sbjct: 190 ----THGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEY 245 Query: 231 QLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRML 290 L I P ++ + + R ++ A + ++ Sbjct: 246 MLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGM---------AMLCETIEECW 296 Query: 291 VFDPAKRITA 300 D R++A Sbjct: 297 DHDAEARLSA 306 >5LPZ-A nrPDB Length = 332 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 56/234 (23%), Positives = 98/234 (41%), Gaps = 25/234 (10%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 + ++ F SL+G G +G V A K G VAIKK+ + E++ + Sbjct: 12 LLQATNGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDRE-FMAEMETIGK 69 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM-----LSDDHIQYFIY 119 KH N++ + + +E ++ E M+ L V+ L+ + Sbjct: 70 IKHRNLVPLLGYCKVG-----DERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAI 124 Query: 120 QTLRAVKVLHGS---NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 + R + LH + ++IHRD+K SN+L++ N + +V DFG+AR++ Sbjct: 125 GSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLM--------SAMDTH 176 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 ++ T Y PE + S DV+S G +L EL + D+ Sbjct: 177 LSVSTLAGTPGYVPPEYYQSFRC-STKGDVYSYGVVLLELLTGKRPTDSPDFGD 229 >5LPV-A nrPDB Length = 296 Score = 167 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 56/234 (23%), Positives = 98/234 (41%), Gaps = 25/234 (10%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 + ++ F SL+G G +G V A K G VAIKK+ + E++ + Sbjct: 12 LLQATNGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDRE-FMAEMETIGK 69 Query: 66 FKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM-----LSDDHIQYFIY 119 KH N++ + + +E ++ E M+ L V+ L+ + Sbjct: 70 IKHRNLVPLLGYCKVG-----DERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAI 124 Query: 120 QTLRAVKVLHGS---NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 + R + LH + ++IHRD+K SN+L++ N + +V DFG+AR++ Sbjct: 125 GSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLM--------SAMDTH 176 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 ++ T Y PE + S DV+S G +L EL + D+ Sbjct: 177 LSVSTLAGTPGYVPPEYYQSFRC-STKGDVYSYGVVLLELLTGKRPTDSPDFGD 229 >2BUJ-A nrPDB Length = 317 Score = 167 bits (423), Expect = 7e-42, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 101/308 (32%), Gaps = 44/308 (14%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 + LGEG + V G A+K+I + RE + + F H NI+ Sbjct: 31 YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRI-LCHEQQDREEAQREADMHRLFNHPNIL 89 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST-----QMLSDDHIQYFIYQTLRAVKV 127 + + ++ + L I L++D I + + R ++ Sbjct: 90 RLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEA 149 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 +H HRDLKP+N+L+ + D G + + Q + T Sbjct: 150 IHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRC-TIS 208 Query: 188 YRAPEVMLTSAK--YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 YRAPE+ + DVWS GC+L + + ++ G Sbjct: 209 YRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY-------DMVFQKGDSVALAVQ 261 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK---- 301 N L +SPR + LL M+ DP +R Sbjct: 262 NQLSIPQSPRH----------------------SSALWQLLNSMMTVDPHQRPHIPLLLS 299 Query: 302 --EALEHP 307 EAL+ P Sbjct: 300 QLEALQPP 307 >3UIM-A nrPDB Length = 326 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 54/226 (23%), Positives = 95/226 (42%), Gaps = 15/226 (6%) Query: 2 PKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIK 61 R + S +F K++LG G +G V G +VA+K+++ L+ E++ Sbjct: 21 SLRELQVASDNFSNKNILGRGGFGKVYKGRL-ADGTLVAVKRLKEERTQGGELQFQTEVE 79 Query: 62 ILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM-LSDDHIQYFIYQ 120 ++ H N++ + + Y+ + + L +Q L Q Sbjct: 80 MISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALG 139 Query: 121 TLRAVKVLHGS---NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 + R + LH +IHRD+K +N+L++ + V DFGLA+++D Sbjct: 140 SARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHV-------- 191 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 T T + APE L++ K S DV+ G +L EL + F Sbjct: 192 -TTAVRGTIGHIAPE-YLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >5IKW-A nrPDB Length = 310 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 71/330 (21%), Positives = 117/330 (35%), Gaps = 55/330 (16%) Query: 14 QLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HENII 72 L+ L EG + V G A+K++ + P + REI I+K H+NI+ Sbjct: 17 TLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNV-CKREITIMKELSGHKNIV 74 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQTD-----LHRVISTQMLSDDHIQYFIYQTLRAVKV 127 + +N EV I+ E + +++ + T ++ + T AV Sbjct: 75 GYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTG-FTEPEVLQIFCDTCEAVAR 133 Query: 128 LHGSN--VIHRDLKPSNLLINSNCDLKVCDFGLA--RIIDESAADNSEPTGQQSGMTEYV 183 LH +IHRDLK N+L+N + +CDFG A + ++ + + T Sbjct: 134 LHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYT--- 190 Query: 184 ATRWYRAPEVML--TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 T YRAPE++ + D+W+ GC+L +L F Q+ + G Sbjct: 191 -TLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFG----ESQVAICDGNFTI 245 Query: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 P + R I L++ ML DP R Sbjct: 246 PDNSRYSRNIHC-------------------------------LIRFMLEPDPEHRPDIF 274 Query: 302 EALEHPY-LQTYHDPNDEPEGEPIPPSFFE 330 + + P IP + E Sbjct: 275 QVSYFAFKFAAADCPVSNINNSSIPSALPE 304 >2PMN-X nrPDB Length = 348 Score = 163 bits (414), Expect = 7e-41, Method: Composition-based stats. Identities = 75/334 (22%), Positives = 129/334 (38%), Gaps = 59/334 (17%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFAL---------------- 54 +D+++ L +G + + + A+KK E Sbjct: 31 NDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYD 88 Query: 55 RTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDH- 113 E++I+ K+E +T I N++EVYII E M+ D D Sbjct: 89 DFKNELQIITDIKNEYCLTCEGIIT-----NYDEVYIIYEYMENDSILKFDEYFFVLDKN 143 Query: 114 ---------IQYFIYQTLRAVKVLH-GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIID 163 I+ I L + +H N+ HRD+KPSN+L++ N +K+ DFG + + Sbjct: 144 YTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMV 203 Query: 164 ESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKY-SRAMDVWSCGCILAELFLRRPI 222 + S T + PE + Y +D+WS G L +F Sbjct: 204 DKKIKGSR------------GTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVP 251 Query: 223 FPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKG 282 F + L+ +F I T + IE P R + + F ++ + Sbjct: 252 F---SLKISLVELFNNIRT-------KNIEYPLDRNHFLYPLTNKKSTCSNNF--LSNED 299 Query: 283 IDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 ID L+ L +PA+RIT+++AL+H +L + + Sbjct: 300 IDFLKLFLRKNPAERITSEDALKHEWLADTNIED 333 >4G3E-A nrPDB Length = 352 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 50/208 (24%), Positives = 89/208 (42%), Gaps = 20/208 (9%) Query: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 +G G++G V K TG A+KK+ +F + E+ I+ ++ Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRL---EVFRVE---ELVACAGLSSPRIVPLYGAV 135 Query: 79 RPDSFENFNEVYIIQELMQTD-LHRVIST-QMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 R + N I EL++ L ++I L +D Y++ Q L ++ LH ++H Sbjct: 136 REGPWVN-----IFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHG 190 Query: 137 DLKPSNLLINSNC-DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVML 195 D+K N+L++S+ +CDFG A + S TG T + APEV++ Sbjct: 191 DVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIP-----GTETHMAPEVVM 245 Query: 196 TSAKYSRAMDVWSCGCILAELFLRRPIF 223 +D+WS C++ + + Sbjct: 246 GKPC-DAKVDIWSSCCMMLHMLNGCHPW 272 >4JLC-A nrPDB Length = 657 Score = 162 bits (411), Expect = 1e-40, Method: Composition-based stats. Identities = 59/241 (24%), Positives = 97/241 (40%), Gaps = 19/241 (7%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITI 74 L +LG+GA V HK TG++ A+K +RE ++LK H+NI+ + Sbjct: 12 LSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 71 Query: 75 FNIQRPDSFENFNEVYIIQELMQ-TDLHRVIST----QMLSDDHIQYFIYQTLRAVKVLH 129 F I+ + + +I E L+ V+ L + + + + L Sbjct: 72 FAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 128 Query: 130 GSNVIHRDLKPSNLL--INSNCD--LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 + ++HRD+KP N++ I + K+ DFG AR +++ E G EY+ Sbjct: 129 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-----EQFVSLYGTEEYLHP 183 Query: 186 RWY-RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF-PGRDYRHQLLLIFGIIGTPH 243 Y RA KY +D+WS G F P R +++ II Sbjct: 184 DMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 243 Query: 244 S 244 S Sbjct: 244 S 244 >5WNO-A nrPDB Length = 330 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 64/275 (23%), Positives = 105/275 (38%), Gaps = 24/275 (8%) Query: 3 KRIVYNISSDFQ--LKSLLGEGAYGVVCSATH-----KPTGEIVAIKKIEPFDKPLFALR 55 RI SS+ Q L LG GA+G V + + K VAIK + Sbjct: 12 SRICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQ--TDQSQTDE 69 Query: 56 TLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQ 115 L E + +H+N++ I D +Y +Q L + + L Sbjct: 70 MLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLK--LHKENLGAREQV 127 Query: 116 YFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQ 175 + YQ ++ L V+HRDL N+L+ +++ DFGL++I+ A + +G+ Sbjct: 128 LYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGK 187 Query: 176 QSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPG---RDYRHQ 231 VA +W A E + + Y+ A DVW+ G E+ + + G + Sbjct: 188 -------VAIKW-LAIE-IFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNF 238 Query: 232 LLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMY 266 L + P+ DL KS P + Sbjct: 239 LKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGF 273 >4FL3-A nrPDB Length = 635 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 49/229 (21%), Positives = 93/229 (40%), Gaps = 24/229 (10%) Query: 17 SLLGEGAYGVVCSATHK-----PTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 LG G +G V ++ T + +K + P L E +++ + I Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILK--NEANDPALKDELLAEANVMQQLDNPYI 432 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM-LSDDHIQYFIYQTLRAVKVLH 129 + + I +S+ ++ E+ + L++ + + D +I ++Q +K L Sbjct: 433 VRMIGICEAESW------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 SN +HRDL N+L+ + K+ DFGL++ + T + +WY Sbjct: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW------PVKWY- 539 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFG 237 APE + K+S DVWS G ++ E F + + G ++ Sbjct: 540 APECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 >4EUU-A nrPDB Length = 319 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 59/241 (24%), Positives = 97/241 (40%), Gaps = 19/241 (7%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITI 74 L +LG+GA V HK TG++ AIK +RE ++LK H+NI+ + Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 72 Query: 75 FNIQRPDSFENFNEVYIIQELMQ-TDLHRVIST----QMLSDDHIQYFIYQTLRAVKVLH 129 F I+ + + +I E L+ V+ L + + + + L Sbjct: 73 FAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 129 Query: 130 GSNVIHRDLKPSNLL--INSNCD--LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 + ++HR++KP N++ I + K+ DFG AR +++ E G EY+ Sbjct: 130 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-----EQFVSLYGTEEYLHP 184 Query: 186 RWY-RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF-PGRDYRHQLLLIFGIIGTPH 243 Y RA KY +D+WS G F P R +++ II Sbjct: 185 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 244 Query: 244 S 244 S Sbjct: 245 S 245 >5TE0-A nrPDB Length = 347 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 70/343 (20%), Positives = 125/343 (36%), Gaps = 58/343 (16%) Query: 14 QLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HENII 72 + +L EG + +V G A+K++ ++ + REI+I++ H+NI+ Sbjct: 22 TVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQV-CKREIQIMRDLSGHKNIV 79 Query: 73 TIFNIQRPD-SFENFNEVYIIQELMQTD-----LHRVISTQMLSDDHIQYFIYQTLRAVK 126 + + S + EV I+ + + +++ + T +++ + T AV Sbjct: 80 GYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTENEVLQIFCDTCEAVA 138 Query: 127 VLHGSN--VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 LH +IHRDLK N+L++ +CDFG A ++ +E + Sbjct: 139 RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSAT--NKFQNPQTEGVNAVEDEIKKYT 196 Query: 185 TRWYRAPEV--MLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 T YRAPE+ + + + D+W+ GC+L +L F Q+ + G P Sbjct: 197 TLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFG----ESQVAICDGNFTIP 252 Query: 243 HSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKE 302 + + + L++ ML DP KR + Sbjct: 253 DNSRYSQDMHC-------------------------------LIRYMLEPDPDKRPDIYQ 281 Query: 303 ALEHPYLQ----TYHDPNDEPEGEPIPPSFFEFDHYKEALTTK 341 Y P + PIP E EA K Sbjct: 282 V---SYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKK 321 >4EUT-A nrPDB Length = 396 Score = 160 bits (406), Expect = 6e-40, Method: Composition-based stats. Identities = 59/241 (24%), Positives = 97/241 (40%), Gaps = 19/241 (7%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITI 74 L +LG+GA V HK TG++ AIK +RE ++LK H+NI+ + Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 72 Query: 75 FNIQRPDSFENFNEVYIIQELMQ-TDLHRVIST----QMLSDDHIQYFIYQTLRAVKVLH 129 F I+ + + +I E L+ V+ L + + + + L Sbjct: 73 FAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 129 Query: 130 GSNVIHRDLKPSNLL--INSNCD--LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 + ++HR++KP N++ I + K+ DFG AR +++ E G EY+ Sbjct: 130 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-----EQFVSLYGTEEYLHP 184 Query: 186 RWY-RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF-PGRDYRHQLLLIFGIIGTPH 243 Y RA KY +D+WS G F P R +++ II Sbjct: 185 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 244 Query: 244 S 244 S Sbjct: 245 S 245 >5CEK-A nrPDB Length = 263 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 61/287 (21%), Positives = 108/287 (37%), Gaps = 53/287 (18%) Query: 27 VCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENF 86 V A TG + K P +R ++ H NI I + ++ Sbjct: 25 VSRALCIHTGRELRCKVF-PIKHYQDKIRPY-----IQLPSHSNITGIVEVILGET---- 74 Query: 87 NEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLI 145 + Y+ E D+H + S + L ++ Q + AV H S ++ DLK + Sbjct: 75 -KAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVF 133 Query: 146 NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYS-RAM 204 ++ ++ ES D G+ +++ Y +PE++ T+ YS +A Sbjct: 134 STEERTQL--------RLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAA 185 Query: 205 DVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLP 264 DVWS G +L L + R F D I R +P Sbjct: 186 DVWSLGVMLYTLLVGRYPFHDSDPSALFSKI---------------------RRGQFCIP 224 Query: 265 MYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQT 311 + ++PK L++ +L +P++R+TA E L HP+ ++ Sbjct: 225 EH-----------ISPKARCLIRSLLRREPSERLTAPEILLHPWFES 260 >6DC0-A nrPDB Length = 292 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 61/287 (21%), Positives = 108/287 (37%), Gaps = 53/287 (18%) Query: 27 VCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENF 86 V A TG + K P +R ++ H NI I + ++ Sbjct: 22 VSRALCIHTGRELRCKVF-PIKHYQDKIRPY-----IQLPSHSNITGIVEVILGET---- 71 Query: 87 NEVYIIQELMQTDLHRVI-STQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLI 145 + Y+ E D+H + S + L ++ Q + AV H S ++ DLK + Sbjct: 72 -KAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVF 130 Query: 146 NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYS-RAM 204 ++ ++ ES D G+ +++ Y +PE++ T+ YS +A Sbjct: 131 STEERTQL--------RLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAA 182 Query: 205 DVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLP 264 DVWS G +L L + R F D I R +P Sbjct: 183 DVWSLGVMLYTLLVGRYPFHDSDPSALFSKI---------------------RRGQFCIP 221 Query: 265 MYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQT 311 + ++PK L++ +L +P++R+TA E L HP+ ++ Sbjct: 222 EH-----------ISPKARCLIRSLLRREPSERLTAPEILLHPWFES 257 >3ZZW-A nrPDB Length = 289 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 55/281 (19%), Positives = 100/281 (35%), Gaps = 41/281 (14%) Query: 14 QLKSLLGEGAYGVVCSATH-----KPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 + LGE +G V + VAIK ++ + E + +H Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQH 71 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELM-QTDLHRVIS-----------------TQMLS 110 N++ + + D + +I DLH + L Sbjct: 72 PNVVCLLGVVTKD-----QPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALE 126 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNS 170 + + Q ++ L +V+H+DL N+L+ ++K+ D GL R + AAD Sbjct: 127 PPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREV--YAADYY 184 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYR 229 + G + RW APE ++ K+S D+WS G +L E+F + G + Sbjct: 185 KLLGN-----SLLPIRW-MAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQ 237 Query: 230 HQLLLIFGIIGTPHSDN---DLRCIESPRAREYIKSLPMYP 267 + +I P D+ + + E+ P + Sbjct: 238 DVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFK 278 >6O8B-A nrPDB Length = 665 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 59/241 (24%), Positives = 98/241 (40%), Gaps = 19/241 (7%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITI 74 L +LG+GA V HK TG++ AIK +RE ++LK H+NI+ + Sbjct: 19 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 78 Query: 75 FNIQRPDSFENFNEVYIIQELMQ-TDLHRVIST----QMLSDDHIQYFIYQTLRAVKVLH 129 F I+ + + +I E L+ V+ L + + + + L Sbjct: 79 FAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 135 Query: 130 GSNVIHRDLKPSNLL--INSNCD--LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 + ++HR++KP N++ I + K+ DFG AR +++ E + G EY+ Sbjct: 136 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-----EQFVELYGTEEYLHP 190 Query: 186 RWY-RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF-PGRDYRHQLLLIFGIIGTPH 243 Y RA KY +D+WS G F P R +++ II Sbjct: 191 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 250 Query: 244 S 244 S Sbjct: 251 S 251 >5C26-A nrPDB Length = 299 Score = 158 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 49/229 (21%), Positives = 93/229 (40%), Gaps = 24/229 (10%) Query: 17 SLLGEGAYGVVCSATHK-----PTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 LG G +G V ++ T + +K + P L E +++ + I Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILK--NEANDPALKDELLAEANVMQQLDNPYI 90 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM-LSDDHIQYFIYQTLRAVKVLH 129 + + I +S+ ++ E+ + L++ + + D +I ++Q +K L Sbjct: 91 VRMIGICEAESW------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 144 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 SN +HRDL N+L+ + K+ DFGL++ + T + +WY Sbjct: 145 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW------PVKWY- 197 Query: 190 APEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFG 237 APE + K+S DVWS G ++ E F + + G ++ Sbjct: 198 APECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 245 >6NT9-A nrPDB Length = 742 Score = 158 bits (399), Expect = 4e-39, Method: Composition-based stats. Identities = 59/241 (24%), Positives = 97/241 (40%), Gaps = 19/241 (7%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITI 74 L +LG+GA V HK TG++ AIK +RE ++LK H+NI+ + Sbjct: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 Query: 75 FNIQRPDSFENFNEVYIIQELMQ-TDLHRVIST----QMLSDDHIQYFIYQTLRAVKVLH 129 F I+ + + +I E L+ V+ L + + + + L Sbjct: 71 FAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 Query: 130 GSNVIHRDLKPSNLL--INSNCD--LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 + ++HR++KP N++ I + K+ DFG AR +++ E G EY+ Sbjct: 128 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-----EQFVSLYGTEEYLHP 182 Query: 186 RWY-RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF-PGRDYRHQLLLIFGIIGTPH 243 Y RA KY +D+WS G F P R +++ II Sbjct: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 Query: 244 S 244 S Sbjct: 243 S 243 >5E8V-A nrPDB Length = 316 Score = 157 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 70/330 (21%), Positives = 120/330 (36%), Gaps = 66/330 (20%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTG----EIVAIKKI--EPFDKPLFALRTLREIKILKHF 66 +L +L+G+G + V A K E VA+K E + +I Sbjct: 11 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDIN----L 66 Query: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 KHENI+ + + I + +L ++ ++S + ++ R + Sbjct: 67 KHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIA 126 Query: 127 VLHGSN---------VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 LH + ++HRDLK SN+L+ ++ +CDFGL+ +D + + Sbjct: 127 HLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPT------LSVDDL 180 Query: 178 GMTEYVATRWYRAPEVM-----LTSAKYSRAMDVWSCGCILAELFLR----------RPI 222 + V T Y APEV+ L + + + DV+S +L E+ R P Sbjct: 181 ANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPP 240 Query: 223 FPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKG 282 F G R P + + + R P P+ L ++ + Sbjct: 241 F-GSKVREH----------PCVASMADNVLADAGR------PEIPSFWLNHQGIQMVCET 283 Query: 283 IDLLQRMLVFDPAKRITAKEA------LEH 306 L DP R+TA+ LEH Sbjct: 284 ---LTECWDHDPEARLTAQCVAERFSELEH 310 >4F0G-A nrPDB Length = 287 Score = 157 bits (396), Expect = 9e-39, Method: Composition-based stats. Identities = 52/315 (16%), Positives = 105/315 (33%), Gaps = 66/315 (20%) Query: 2 PKRIVYNISS-DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFAL------ 54 PK + ++ + + + +G+G +G+V +VAIK + D Sbjct: 9 PKSRLPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQ 68 Query: 55 RTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVI--STQMLSD 111 RE+ I+ + H NI+ ++ + ++ E + DL+ + + Sbjct: 69 EFQREVFIMSNLNHPNIVKLYGLMHNPPR-------MVMEFVPCGDLYHRLLDKAHPIKW 121 Query: 112 DHIQYFIYQTLRAVKVLHGSN--VIHRDLKPSNLL---INSNCDL--KVCDFGLARIIDE 164 + ++ + N ++HRDL+ N+ ++ N + KV DFGL++ Sbjct: 122 SVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVH 181 Query: 165 SAADNSEPTGQQSGMTEYVATRWYRAPEVM-LTSAKYSRAMDVWSCGCILAELFLRRPIF 223 S + + + APE + Y+ D +S IL + F Sbjct: 182 SV-------------SGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPF 228 Query: 224 PGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI 283 D + I+ + P P P+ Sbjct: 229 -----------------------DEYSYGKIKFINMIREEGLRPTIPE-----DCPPRLR 260 Query: 284 DLLQRMLVFDPAKRI 298 ++++ DP KR Sbjct: 261 NVIELCWSGDPKKRP 275 >4M66-A nrPDB Length = 325 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 53/298 (17%), Positives = 114/298 (38%), Gaps = 38/298 (12%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHEN 70 + + +G+G +GVV A H+ VA+K + + E+K + + ++EN Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNS-------KKISWEVKAMVNLRNEN 72 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQ-MLSDDHIQYFIYQTLRAVKVL 128 ++ + + ++ + ++ M+ L ++ + + + + + + L Sbjct: 73 VLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYL 132 Query: 129 HGSN--VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H + ++HRDLKPSN+L++ K+ DFGL+ S + + +G + T Sbjct: 133 HSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGG----TL 188 Query: 187 WYRAPEVMLT-SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Y PE++ + K S+A DV+S G ++ + R Sbjct: 189 AYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR---------------------EAEL 227 Query: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 D + + P+ P P + K +L+ R + ++ Sbjct: 228 VDKTSLIRETVCDRQSRPPLTELPPGSPETPGL-EKLKELMIHCWGSQSENRPSFQDC 284 >2QKW-B nrPDB Length = 321 Score = 156 bits (394), Expect = 1e-38, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 115/310 (37%), Gaps = 37/310 (11%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 +P + +++F K L+G G +G V + G VA+K+ P I Sbjct: 29 VPLVDLEEATNNFDHKFLIGHGVFGKVYKGVLR-DGAKVALKRRTPESSQGIEEFETE-I 86 Query: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVI-----STQMLSDDHI 114 + L +H +++++ + NE+ +I + M+ +L R + T +S + Sbjct: 87 ETLSFCRHPHLVSLIGFC-----DERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQR 141 Query: 115 QYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTG 174 R + LH +IHRD+K N+L++ N K+ DFG+++ Sbjct: 142 LEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKK--------GTELD 193 Query: 175 QQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLL 234 Q T T Y PE + + + DV+S G +L E+ R R + L Sbjct: 194 QTHLSTVVKGTLGYIDPEYFI-KGRLTEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNL 252 Query: 235 IFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDP 294 + + H++ L I P + I+ + + L Sbjct: 253 AEWAVES-HNNGQLEQIVDPNLADKIRPESLRKFGDTAV--------------KCLALSS 297 Query: 295 AKRITAKEAL 304 R + + L Sbjct: 298 EDRPSMGDVL 307 >2H34-A nrPDB Length = 309 Score = 156 bits (394), Expect = 1e-38, Method: Composition-based stats. Identities = 54/234 (23%), Positives = 94/234 (40%), Gaps = 19/234 (8%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLREIKILKHFKHEN 70 ++L+ L+G G G V A IVA+K + P+F R RE + + + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQM-LSDDHIQYFIYQTLRAVKVL 128 ++ I + D ++Y+ L+ DL ++ Q L+ + Q A+ Sbjct: 96 VVPIHDFGEID-----GQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAA 150 Query: 129 HGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 H + HRD+KP N+L++++ + DFG+A + + V T +Y Sbjct: 151 HAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQ---------LGNTVGTLYY 201 Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 APE S + D+++ C+L E P + G I I P Sbjct: 202 MAPERFSESHA-TYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRP 254 >6BFN-A nrPDB Length = 342 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 64/325 (19%), Positives = 113/325 (34%), Gaps = 40/325 (12%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLF---ALRTLRE 59 R +N S + + +GEG +G V A + T + A+K+++ + L E Sbjct: 18 SRGTHNFSEELK----IGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTE 71 Query: 60 IKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ-----MLSDDHI 114 ++ L F+H NI+ + F + L L + Q LS Sbjct: 72 VEQLSRFRHPNIVDFAGYCAQNGF----YCLVYGFLPNGSLEDRLHCQTQACPPLSWPQR 127 Query: 115 QYFIYQTLRAVKVLH--GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEP 172 + T RA++ LH ++IH D+K SN+L++ K+ DFGLAR A + Sbjct: 128 LDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLAR-FSRFAGSSPSQ 186 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 + + T Y PE + + + + D +S G ++ E + R + Sbjct: 187 SSMVARTQTVRGTLAYL-PEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKY 245 Query: 233 LLIFGIIGTPHSDNDLRCIESPR--------------AREYIKSLPMYPAAPLEKMFPRV 278 L + LR +S + Y K L P ++ + Sbjct: 246 LKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGL 305 Query: 279 NPKGIDLLQRMLVFDPAKRITAKEA 303 L +R + Sbjct: 306 GQLACC----CLHRRAKRRPPMTQV 326 >5AR8-A nrPDB Length = 326 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 61/299 (20%), Positives = 109/299 (36%), Gaps = 30/299 (10%) Query: 16 KSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD--KPLFALRTLREIKILKHFKHENIIT 73 L GA G V SA H VA+K + LRE +IL + I+ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 74 IFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQM----LSDDHIQYFIYQTLRAVKVL 128 I I F + I+ E M L+ ++ + ++ +++ V L Sbjct: 97 ILGICNEPEF-----LGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYL 151 Query: 129 HGSN--VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 H ++H DLK N+L+++ +K+ DFGL++ S + + G T Sbjct: 152 HNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEG-----GTI 206 Query: 187 WYRAPEVML--TSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 Y PE ++ S D++S I E+ R+ F Q++ P Sbjct: 207 IYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVI 266 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 + + + P I + E + + + L+ ++ +P R T +E Sbjct: 267 NEESLPYDIPHRARMISLI--------ESGWAQNPDERPSFLKCLIELEPVLR-TFEEI 316 >2QLU-A nrPDB Length = 314 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 108/305 (35%), Gaps = 40/305 (13%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 QL + G +G V A VA+K DK + REI KHEN++ Sbjct: 17 LQLLEIKARGRFGCVWKAQLMND--FVAVKIFPLQDKQSWQSE--REIFSTPGMKHENLL 72 Query: 73 TIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHG- 130 ++ S E+++I L + +++ + + + R + LH Sbjct: 73 QFIAAEKRGS-NLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHED 131 Query: 131 ----------SNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 ++ HRD K N+L+ S+ + DFGLA EP Sbjct: 132 VPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRF--------EPGKPPGDTH 183 Query: 181 EYVATRWYRAPEVMLTSAKYSR----AMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 V TR Y APEV+ + + R +D+++ G +L EL R G + L Sbjct: 184 GQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEE 243 Query: 237 GIIGTPHSDNDLRCIESPRAREYIKS-LPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPA 295 I P + + + R IK +P + ++ D Sbjct: 244 EIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVT----------IEECWDHDAE 293 Query: 296 KRITA 300 R++A Sbjct: 294 ARLSA 298 >3LMG-A nrPDB Length = 344 Score = 151 bits (381), Expect = 5e-37, Method: Composition-based stats. Identities = 62/324 (19%), Positives = 110/324 (33%), Gaps = 59/324 (18%) Query: 3 KRIVYNISSDFQL--KSLLGEGAYGVVCSATHKPTGE----IVAIKKIEPFDKPLFALRT 56 +++ I + +L +LG G +G V P GE V IK IE Sbjct: 21 NKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAV 80 Query: 57 LREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM--LSDDH 113 + + H +I+ + + S + ++ + + L + L Sbjct: 81 TDHMLAIGSLDHAHIVRLLGLCPGSSLQ------LVTQYLPLGSLLDHVRQHRGALGPQL 134 Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPT 173 + + Q + + L ++HR+L N+L+ S ++V DFG+A ++ P Sbjct: 135 LLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLL---------PP 185 Query: 174 GQQSGMTEYVATRW-YRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQ 231 + + T + A E + KY+ DVWS G + EL + G Sbjct: 186 DDKQLLYSEAKTPIKWMALESI-HFGKYTHQSDVWSYGVTVWELMTFGAEPYAG------ 238 Query: 232 LLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLV 291 LR E P E + L ++ V + + Sbjct: 239 ----------------LRLAEVPDLLEKGERLAQPQICTIDVYMVMV---------KCWM 273 Query: 292 FDPAKRITAKEALEHPYLQTYHDP 315 D R T KE L + + + DP Sbjct: 274 IDENIRPTFKE-LANEFTRMARDP 296 >2Y4I-B nrPDB Length = 319 Score = 147 bits (370), Expect = 9e-36, Method: Composition-based stats. Identities = 57/309 (18%), Positives = 114/309 (36%), Gaps = 43/309 (13%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHE 69 ++ L+G+G +G V VAI+ I+ D RE+ + +HE Sbjct: 33 EQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE 89 Query: 70 NIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQM--LSDDHIQYFIYQTLRAVK 126 N++ + II L + L+ V+ L + + + ++ + Sbjct: 90 NVVLFMGACMSPP-----HLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMG 144 Query: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 LH ++H+DLK N+ + N + + DFGL I A E + Sbjct: 145 YLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQN-----GWL 198 Query: 187 WYRAPEVMLT--------SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGI 238 + APE++ +S+ DV++ G I EL R F + + + Sbjct: 199 CHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTG 258 Query: 239 IGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI 298 + + + I + ++ A ++ P K +D+L+++ + +R+ Sbjct: 259 MKP--------NLSQIGMGKEISDILLFCWAFEQEERPTFT-KLMDMLEKLPKRN--RRL 307 Query: 299 TAKEALEHP 307 + HP Sbjct: 308 S------HP 310 >4BTK-A nrPDB Length = 337 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 52/237 (21%), Positives = 94/237 (39%), Gaps = 21/237 (8%) Query: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 Y + +++ +G G +G + A T E VA+K +E +P L+ E+ +LK Sbjct: 52 YVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKM--EVAVLKKL 108 Query: 67 KHE-NIITIFNIQRPDSFENFNEVYIIQELMQ---TDLHRVISTQMLSDDHIQYFIYQTL 122 + + ++ R + F Y++ +L DL R + Q L Sbjct: 109 QGKDHVCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQIL 163 Query: 123 RAVKVLHGSNVIHRDLKPSNL----LINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 +++ +H +HRD+KPSN L ++ + DFGLAR + D P Sbjct: 164 ESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVA-- 221 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLI 235 + T Y + R D+WS +L E + + + + Q+ +I Sbjct: 222 --GFRGTVRYASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMI 275 >4NFN-A nrPDB Length = 309 Score = 145 bits (365), Expect = 4e-35, Method: Composition-based stats. Identities = 52/237 (21%), Positives = 94/237 (39%), Gaps = 21/237 (8%) Query: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF 66 Y + +++ +G G +G + A T E VA+K +E +P L+ E+ +LK Sbjct: 17 YVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKM--EVAVLKKL 73 Query: 67 KHE-NIITIFNIQRPDSFENFNEVYIIQELMQ---TDLHRVISTQMLSDDHIQYFIYQTL 122 + + ++ R + F Y++ +L DL R + Q L Sbjct: 74 QGKDHVCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQIL 128 Query: 123 RAVKVLHGSNVIHRDLKPSNL----LINSNCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 +++ +H +HRD+KPSN L ++ + DFGLAR + D P Sbjct: 129 ESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVA-- 186 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLI 235 + T Y + R D+WS +L E + + + + Q+ +I Sbjct: 187 --GFRGTVRYASVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMI 240 >3SV0-A nrPDB Length = 483 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 49/227 (21%), Positives = 93/227 (40%), Gaps = 24/227 (10%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 + + F+L +G G++G + T+ T E VAIK + + L E KI + + Sbjct: 4 RVGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK---LENVKTKHPQLLYESKIYRILQ 60 Query: 68 H----ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS--TQMLSDDHIQYFIYQT 121 N + F + + ++ +L+ L + + ++ LS + Q Sbjct: 61 GGTGIPN-VRWFGV-------EGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQM 112 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLIN---SNCDLKVCDFGLARIIDESAADNSEPTGQQSG 178 + V+ +H + +HRD+KP N L+ + + DFGLA+ +++ P + Sbjct: 113 INRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKN 172 Query: 179 MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG 225 +T T Y + L + SR D+ S G +L + G Sbjct: 173 LT---GTARYASVNTHLG-IEQSRRDDLESLGYVLMYFLRGSLPWQG 215 >4TN6-A nrPDB Length = 318 Score = 137 bits (346), Expect = 5e-33, Method: Composition-based stats. Identities = 50/225 (22%), Positives = 88/225 (39%), Gaps = 20/225 (8%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIK-KIEPFDKPLFALRTLREIKILKHF 66 + + ++L +G G++G + T GE VAIK + P + E KI K Sbjct: 4 RVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHI----ESKIYKMM 59 Query: 67 KHENIITIFNIQRPDSFENFNEV-YIIQELMQTDLHRVIS--TQMLSDDHIQYFIYQTLR 123 + I + ++ EL+ L + + ++ S + Q + Sbjct: 60 Q-----GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMIS 114 Query: 124 AVKVLHGSNVIHRDLKPSNLLI---NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 ++ +H N IHRD+KP N L+ + + DFGLA+ ++ P + +T Sbjct: 115 RIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLT 174 Query: 181 EYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG 225 T Y + L + SR D+ S G +L L + G Sbjct: 175 ---GTARYASINTHLG-IEQSRRDDLESLGYVLMYFNLGSLPWQG 215 >5J0A-A nrPDB Length = 300 Score = 137 bits (346), Expect = 6e-33, Method: Composition-based stats. Identities = 60/305 (19%), Positives = 106/305 (34%), Gaps = 46/305 (15%) Query: 23 AYGV---VCSATHKPTGE---IVAIKKIEPFDKPLFA----LRTLREIKILKHFKHENII 72 +G V P G A+KKI P + R + E KILK H NI+ Sbjct: 18 GFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIV 77 Query: 73 TIFNIQRPDSFENFNEVYIIQELM-QTDLHRVISTQ------MLSDDHIQYFIYQTLRAV 125 N + + E + L+ +I + I R + Sbjct: 78 GYRAFTEA----NDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGL 133 Query: 126 KVLHG-SNVIHRDLKPSNLLINSNCD-LKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 K LH ++H D+K SN++I + + +K+CD G++ +DE+ Y+ Sbjct: 134 KYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENME-------VTDPEACYI 186 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 T ++ E + + + D+++ G L E+ + + Sbjct: 187 GTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP---------HINLSNDDDDED 237 Query: 244 SDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK-- 301 D + + + P L++ + +V I+L DP R +A Sbjct: 238 KTFDESDFDDEAYYAALGTRPPINMEELDESYQKV----IELFSVCTNEDPKDRPSAAHI 293 Query: 302 -EALE 305 EALE Sbjct: 294 VEALE 298 >5FQD-C nrPDB Length = 341 Score = 137 bits (345), Expect = 7e-33, Method: Composition-based stats. Identities = 46/234 (19%), Positives = 94/234 (40%), Gaps = 28/234 (11%) Query: 3 KRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKI 62 + + + ++L +G G++G + A + GE VA+K + + L E K+ Sbjct: 11 SKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK---LESQKARHPQLLYESKL 67 Query: 63 LKHFKH----ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS--TQMLSDDHIQY 116 K + +I + + + ++ +L+ L + + ++ + + Sbjct: 68 YKILQGGVGIPHI-RWYG-------QEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLM 119 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLK---VCDFGLARIIDESAADNSEPT 173 Q + ++ +H N IHRD+KP N L+ + DFGLA+ ++ P Sbjct: 120 LADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPY 179 Query: 174 GQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRP--IFPG 225 + +T T Y + L + SR D+ S G +L ++ R + G Sbjct: 180 REDKNLT---GTARYASINAHLG-IEQSRRDDMESLGYVL--MYFNRTSLPWQG 227 >5L2Q-C nrPDB Length = 320 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 51/315 (16%), Positives = 107/315 (33%), Gaps = 77/315 (24%) Query: 28 CSATHKPTGEIVAIKKIEPFDKPLFALRTLREIK----------ILKHFK-HENIITIFN 76 C A T + +K + ++ + + E + +L + ++ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 77 IQRPDSFEN-------------FNEVYIIQE-LMQTDL-----------HRVISTQMLSD 111 + + + E + ++ + L D H VI + LS+ Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 112 DHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCD-LKVCDFGLARIIDESAADNS 170 Y +R V+ LH N++HRDLK N+++N + + +F L + + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHL-------- 204 Query: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRH 230 + + + + Y +P+V+ + D+W+ G +L + + F + Sbjct: 205 --VSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQE 262 Query: 231 QLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRML 290 I T D RV+ + L++++L Sbjct: 263 LFRKIKAAEYTIPEDG------------------------------RVSENTVCLIRKLL 292 Query: 291 VFDPAKRITAKEALE 305 V DP +R+ A + LE Sbjct: 293 VLDPQQRLAAADVLE 307 >4M69-B nrPDB Length = 283 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 50/286 (17%), Positives = 97/286 (33%), Gaps = 43/286 (15%) Query: 25 GVVCSATHKPTGEIVAIKKIEPFDKPLF---ALRTLREIKILKHFKHENIITIFNIQRPD 81 + + + V IK EIK +K F NI+ IF I Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 82 SFENFNEVYIIQELMQ-TDLHRVISTQM-LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLK 139 + E I+ E + L ++ + L+ + + R + LH S +HR++ Sbjct: 81 TV-KPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNIS 139 Query: 140 PSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAK 199 S+ L+ +K+ F L++ + + ++S T YV+ + P + Sbjct: 140 SSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCL----- 194 Query: 200 YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREY 259 Y +++S G +L E+ + F G D S + RE Sbjct: 195 YDIKAEIYSFGIVLWEIATGKIPFEGCD-------------------------SKKIREL 229 Query: 260 IKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 + E + +++ +P++R + LE Sbjct: 230 VAEDKKQ-----EPVGQDCPELLREIINECRAHEPSQRPSVDGILE 270 >4BTF-A nrPDB Length = 469 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 50/286 (17%), Positives = 97/286 (33%), Gaps = 43/286 (15%) Query: 25 GVVCSATHKPTGEIVAIKKIEPFDKPLF---ALRTLREIKILKHFKHENIITIFNIQRPD 81 + + + V IK EIK +K F NI+ IF I Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 82 SFENFNEVYIIQELMQ-TDLHRVISTQM-LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLK 139 + E I+ E + L ++ + L+ + + R + LH S +HR++ Sbjct: 267 TV-KPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNIS 325 Query: 140 PSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAK 199 S+ L+ +K+ F L++ + + ++S T YV+ + P + Sbjct: 326 SSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCL----- 380 Query: 200 YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREY 259 Y +++S G +L E+ + F G D S + RE Sbjct: 381 YDIKAEIYSFGIVLWEIATGKIPFEGCD-------------------------SKKIREL 415 Query: 260 IKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 + E + +++ +P++R + LE Sbjct: 416 VAEDKKQ-----EPVGQDCPELLREIINECRAHEPSQRPSVDGILE 456 >2PZI-A nrPDB Length = 681 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 61/297 (20%), Positives = 105/297 (35%), Gaps = 56/297 (18%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKP-TGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 ++ +++K + G G + A + G V +K + + E + L Sbjct: 78 VAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV 137 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 H +I+ IFN YI+ E + + Q L ++ + L A+ Sbjct: 138 HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSY 197 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 LH +++ DLKP N+++ LK+ D G I+ T Sbjct: 198 LHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY--------------GTPG 242 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 ++APE++ T + A D+++ G LA L L P GR + G P D Sbjct: 243 FQAPEIVRTGP--TVATDIYTVGRTLAALTLDLPTRNGRY----------VDGLPEDDPV 290 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 L+ +S LL+R + DP +R T E + Sbjct: 291 LKTYDSYGR----------------------------LLRRAIDPDPRQRFTTAEEM 319 >4Y12-A nrPDB Length = 375 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 61/297 (20%), Positives = 105/297 (35%), Gaps = 56/297 (18%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKP-TGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 ++ +++K + G G + A + G V +K + + E + L Sbjct: 117 VAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV 176 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 H +I+ IFN YI+ E + + Q L ++ + L A+ Sbjct: 177 HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSY 236 Query: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 LH +++ DLKP N+++ LK+ D G I+ T Sbjct: 237 LHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY--------------GTPG 281 Query: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247 ++APE++ T + A D+++ G LA L L P GR + G P D Sbjct: 282 FQAPEIVRTGP--TVATDIYTVGRTLAALTLDLPTRNGRY----------VDGLPEDDPV 329 Query: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 L+ +S LL+R + DP +R T E + Sbjct: 330 LKTYDSYGR----------------------------LLRRAIDPDPRQRFTTAEEM 358 >3VHK-A nrPDB Length = 368 Score = 130 bits (327), Expect = 8e-31, Method: Composition-based stats. Identities = 46/204 (22%), Positives = 76/204 (37%), Gaps = 40/204 (19%) Query: 104 ISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIID 163 + L+ +H+ + +Q + ++ L IHRDL N+L++ +K+CDFGLAR I Sbjct: 192 LYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIY 251 Query: 164 ESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPI 222 + + + + APE + Y+ DVWS G +L E+F Sbjct: 252 KDPDYVRKGDARLPLK--------WMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASP 302 Query: 223 FPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKG 282 +PG + R E R R + P L+ Sbjct: 303 YPGVKIDEEFCR--------------RLKEGTRMRAPDYTTPEMYQTMLD---------- 338 Query: 283 IDLLQRMLVFDPAKRITAKEALEH 306 +P++R T E +EH Sbjct: 339 ------CWHGEPSQRPTFSELVEH 356 Score = 74.6 bits (182), Expect = 6e-14, Method: Composition-based stats. Identities = 23/105 (21%), Positives = 40/105 (38%), Gaps = 11/105 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSA----THK-PTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 +L LG GA+G V A K T VA+K ++ + E+KIL H Sbjct: 29 DRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIH 88 Query: 66 FKHE-NIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM 108 H N++ + + +I E + +L + ++ Sbjct: 89 IGHHLNVVNLLGACTKPG----GPLMVIVEFCKFGNLSTYLRSKR 129 >4JRN-A nrPDB Length = 372 Score = 130 bits (327), Expect = 8e-31, Method: Composition-based stats. Identities = 60/343 (17%), Positives = 105/343 (30%), Gaps = 90/343 (26%) Query: 1 MPKRIVYNISSDFQL---KSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFA--LR 55 +PKR V + + + + LG G + V AT T E +A+K +P L Sbjct: 55 VPKRFVSVTTGETRTLVRGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLD 114 Query: 56 TLREIKILKHFKH----------------ENIITIFN------IQRPDSFENFNEVYIIQ 93 RE ++F +++ + + + +++ Sbjct: 115 LQRESSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLM 174 Query: 94 ELMQTDLHRVIS---------TQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLL 144 + D+ +VIS Y Q ++ V + ++H D+KP+N L Sbjct: 175 MRAEADMSKVISWVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFL 234 Query: 145 INSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT--SAKYSR 202 + + L + DFG RI + + + T Y PE Y+ Sbjct: 235 LLKDGRLFLGDFGTYRI--------------NNSVGRAIGTPGYEPPERPFQATGITYTF 280 Query: 203 AMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKS 262 D W G L ++ + P L Sbjct: 281 PTDAWQLGITLYCIWCKERPTPADGIWDYLHF---------------------------- 312 Query: 263 LPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 P DL++ +L DP KR+ +ALE Sbjct: 313 ----------ADCPSTPELVQDLIRSLLNRDPQKRMLPLQALE 345 >5VC6-A nrPDB Length = 289 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 53/324 (16%), Positives = 105/324 (32%), Gaps = 80/324 (24%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKK-IEPFDKPLFALRTLREIKILKHF-K 67 +++F +G G +G V + G I AIK+ +P + LRE+ + Sbjct: 10 TTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQ 69 Query: 68 HENIITIFNIQRPDSFENFNEVYIIQELMQTD-LHRVISTQM-----LSDDHIQYFIYQT 121 H +++ F ++ + + I E L IS + ++ + Q Sbjct: 70 HSHVVRYF-----SAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQV 124 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDL-------------------KVCDFGLARII 162 R ++ +H +++H D+KPSN+ I+ K+ D G I Sbjct: 125 GRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRI 184 Query: 163 DESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPI 222 + + + A EV+ + + D+++ + Sbjct: 185 SSPQVEEGDS--------------RFLANEVLQENYTHLPKADIFALALTVV-CAAGAEP 229 Query: 223 FPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKG 282 P Q I LP P ++ + Sbjct: 230 LP--RNGDQWHEIRQ-----------------------GRLPRIPQV--------LSQEF 256 Query: 283 IDLLQRMLVFDPAKRITAKEALEH 306 +LL+ M+ DP +R +A ++H Sbjct: 257 TELLKVMIHPDPERRPSAMALVKH 280 >3HNG-A nrPDB Length = 360 Score = 127 bits (319), Expect = 9e-30, Method: Composition-based stats. Identities = 47/197 (23%), Positives = 80/197 (40%), Gaps = 17/197 (8%) Query: 81 DSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKP 140 F+ + ++E + D + ++ + + + +Q R ++ L IHRDL Sbjct: 171 SGFQEDKSLSDVEE--EEDSDGFYK-EPITMEDLISYSFQVARGMEFLSSRKCIHRDLAA 227 Query: 141 SNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKY 200 N+L++ N +K+CDFGLAR I P + G T + APE + Y Sbjct: 228 RNILLSENNVVKICDFGLARDI------YKNPDYVRKGDTRL--PLKWMAPESIFDKI-Y 278 Query: 201 SRAMDVWSCGCILAELFL-RRPIFPG----RDYRHQLLLIFGIIGTPHSDNDLRCIESPR 255 S DVWS G +L E+F +PG D+ +L + +S ++ I Sbjct: 279 STKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDC 338 Query: 256 AREYIKSLPMYPAAPLE 272 K P + + Sbjct: 339 WHRDPKERPRFAELVEK 355 Score = 75.0 bits (183), Expect = 5e-14, Method: Composition-based stats. Identities = 23/105 (21%), Positives = 40/105 (38%), Gaps = 11/105 (10%) Query: 11 SDFQLKSLLGEGAYGVVCSA-----THKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 +L LG GA+G V A PT VA+K ++ + E+KIL H Sbjct: 27 ERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTH 86 Query: 66 FKHE-NIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM 108 H N++ + + +I E + +L + ++ Sbjct: 87 IGHHLNVVNLLGACTKQG----GPLMVIVEYCKYGNLSNYLKSKR 127 >5VDK-A nrPDB Length = 297 Score = 127 bits (319), Expect = 9e-30, Method: Composition-based stats. Identities = 49/329 (14%), Positives = 102/329 (31%), Gaps = 88/329 (26%) Query: 8 NISSDFQL----KSLLGEGAYGVVCSATHKPTGEIVAIKK-IEPFDKPLFALRTLREIKI 62 N++S ++ +G G +G V + G + AIK+ ++ F + L E+ Sbjct: 8 NMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYA 67 Query: 63 LKHF-KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRV------ISTQMLSDDHIQ 115 H +++ + S+ + + I E + S + ++ Sbjct: 68 HAVLGHHPHVVRYY-----SSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLK 122 Query: 116 YFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCD-----------------------LK 152 + Q + +H S+++H D+KPSN+ I K Sbjct: 123 DILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYK 182 Query: 153 VCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCI 212 + D G A I++ + + + A E++ ++ D+++ G Sbjct: 183 IGDLGHATSINKPKVEEGDS--------------RFLANEILQEDYRHLPKADIFALGLT 228 Query: 213 LAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLE 272 I G + R +P P E Sbjct: 229 ----------------------IAVAAGAESLPTNGAAWHHIRKGN-------FPDVPQE 259 Query: 273 KMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 ++ LL+ M+ D +R +A Sbjct: 260 -----LSESFSSLLKNMIQPDAEQRPSAA 283 >4MWI-A nrPDB Length = 294 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 53/286 (18%), Positives = 102/286 (35%), Gaps = 47/286 (16%) Query: 28 CSATHKPTGEIVAIKKIEPFDK---PLFALRTLREIKILKHFKHENIITIFNIQRPDSFE 84 + VAIK + + +EIK +K F+ NI+ IF I ++ Sbjct: 41 YKGEYHR--APVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETV- 97 Query: 85 NFNEVYIIQELMQ-TDLHRVISTQM-LSDDHIQYFIYQTLRAVKVLHGSNV--IHRDLKP 140 + I+ E + L ++ + L+ + R + LH S +H ++ Sbjct: 98 TPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRS 157 Query: 141 SNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP-EVMLTSAK 199 SN L+ +K+ F L + + G T+ V + Y +P E+ + Sbjct: 158 SNFLVTQGYQVKLAGFELRKTQTSMSL------GTTREKTDRVKSTAYLSPQELEDVFYQ 211 Query: 200 YSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREY 259 Y +++S G +L E+ F G + S+ + + R +E Sbjct: 212 YDVKSEIYSFGIVLWEIATGDIPFQGCN----------------SEKIRKLVAVKRQQE- 254 Query: 260 IKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 PL + P + +++ DP+ R + E L+ Sbjct: 255 ----------PLGEDCP---SELREIIDECRAHDPSVRPSVDEILK 287 >5X1R-A nrPDB Length = 302 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 42/237 (17%), Positives = 83/237 (35%), Gaps = 40/237 (16%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALR--------------- 55 ++F+++ +GEG +G+V A +AIK+ P Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 56 -----TLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ--- 107 ++E ++L F H ++ + +E Y+ + + + Q Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRF-----WEENGTAYMGTQFYSGTTLKNLQAQQPE 135 Query: 108 MLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAA 167 + + I+ + A+ +H +HRD+ N+ I + + DFG AR Sbjct: 136 KIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARK------ 189 Query: 168 DNSEPTGQQSGMTEYVATRWYRAPEVMLTS--AKYSRAMDVWSCGCILAELFLRRPI 222 G S TE V + E + + D+++ G +L L + P Sbjct: 190 ----EIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP 242 >4RT7-A nrPDB Length = 415 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 50/216 (23%), Positives = 90/216 (41%), Gaps = 23/216 (10%) Query: 58 REIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYF 117 RE++I H + I + +SF + +E I+ Q L +L+ + + F Sbjct: 198 REVQI--HPDSDQISGLHG----NSFHSEDE---IEYENQKRLEEEEDLNVLTFEDLLCF 248 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177 YQ + ++ L + +HRDL N+L+ +K+CDFGLAR I + + Sbjct: 249 AYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNAR-- 306 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFL-RRPIFPGR----DYRHQL 232 + +W APE + Y+ DVWS G +L E+F +PG ++ + Sbjct: 307 -----LPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 359 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPA 268 F + ++ ++ I + P +P Sbjct: 360 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPN 395 Score = 82.3 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 43/105 (40%), Gaps = 12/105 (11%) Query: 11 SDFQLKSLLGEGAYGVVCSATH---KPTGE--IVAIKKIEPFDKPLFALRTLREIKILKH 65 + + +LG GA+G V +AT TG VA+K ++ + E+K++ Sbjct: 65 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQ 124 Query: 66 F-KHENIITIFNIQRPDSFENFNEVYIIQEL-MQTDLHRVISTQM 108 HENI+ + +Y+I E DL + ++ Sbjct: 125 LGSHENIVNLLGACTLS-----GPIYLIFEYCCYGDLLNYLRSKR 164 >2CHL-A nrPDB Length = 351 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 52/291 (17%), Positives = 98/291 (33%), Gaps = 20/291 (6%) Query: 6 VYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH 65 V + +F++ +G G +G + + T E VAIK +EP L E + K Sbjct: 25 VLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHL--EYRFYKQ 81 Query: 66 FKH-ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRV--ISTQMLSDDHIQYFIYQTL 122 + I ++ + ++ EL+ L + + + S + Q + Sbjct: 82 LGSGDGIPQVYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLI 136 Query: 123 RAVKVLHGSNVIHRDLKPSNLLINSNCD-----LKVCDFGLARIIDESAADNSEPTGQQS 177 ++ +H N+I+RD+KP N LI + + + DF LA+ + P + Sbjct: 137 SRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHK 196 Query: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 +T T Y + L + SR D+ + G + + G Sbjct: 197 SLT---GTARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQK 252 Query: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQR 288 I T + E+ + + + DL R Sbjct: 253 IGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 303 >4NT4-A nrPDB Length = 312 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 58/304 (19%), Positives = 106/304 (34%), Gaps = 31/304 (10%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 M V + +F++ +G G +G + + E VAIK +EP L E Sbjct: 2 MDPMAVLMVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIK-MEPMKSKAPQLHL--EY 58 Query: 61 KILKHF-KH-----ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRV--ISTQMLSDD 112 + K H + I I+++ N ++ EL+ L + I + S Sbjct: 59 RFYKLLGSHADNAPDGIPRIYHLGTCGGRYNA----MVLELLGLSLEDLFNICARKFSLK 114 Query: 113 HIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCD-----LKVCDFGLARIIDESAA 167 + Q L ++ +H ++I+RD+KP N LI + + DFGLA+ + Sbjct: 115 TVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDT 174 Query: 168 DNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRD 227 + P + +T T Y + + + SR D+ + G + + G Sbjct: 175 NRHIPYREHKSLT---GTARYMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLK 230 Query: 228 YRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQ 287 L + IG + + E+ L + D L+ Sbjct: 231 -ADTLKERYQKIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDY------DFLR 283 Query: 288 RMLV 291 R+ Sbjct: 284 RLFQ 287 >2CMW-A nrPDB Length = 310 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 53/286 (18%), Positives = 99/286 (34%), Gaps = 24/286 (8%) Query: 14 QLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH--ENI 71 ++ +G G +G + + T E VAIK +EP L E + K E + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHL--EYRFYKQLGSAGEGL 59 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQTDLHRV--ISTQMLSDDHIQYFIYQTLRAVKVLH 129 ++ + ++ EL+ L + + + + + Q L ++ +H Sbjct: 60 PQVYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVH 114 Query: 130 GSNVIHRDLKPSNLLINSNCDLK-----VCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 N+I+RD+KP N LI + K + DFGLA+ + P + +T Sbjct: 115 SKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLT---G 171 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 T Y + L + SR D+ + G + + G L + IG Sbjct: 172 TARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKR 229 Query: 245 DNDLR--CIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQR 288 + + C P + + + DL ++ Sbjct: 230 NTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEK 275 >5X18-A nrPDB Length = 295 Score = 118 bits (296), Expect = 4e-27, Method: Composition-based stats. Identities = 45/221 (20%), Positives = 85/221 (38%), Gaps = 20/221 (9%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH-ENI 71 +++ +GEG++GV+ T+ G VAIK + A + E K K NI Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKF---EPRKTEAPQLRDEYKTYKILNGTPNI 65 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI--STQMLSDDHIQYFIYQTLRAVKVLH 129 + N ++ +L+ L + + S + Q + ++ LH Sbjct: 66 -PYAYYFGQEGLHNI----LVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLH 120 Query: 130 GSNVIHRDLKPSNLLINSNCD-----LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 ++I+RD+KP N LI + + DFG+A+ + P ++ ++ Sbjct: 121 AHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLS---G 177 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG 225 T Y + L + SR D+ + G + + G Sbjct: 178 TARYMSINTHLGREQ-SRRDDMEALGHVFFYFLRGHLPWQG 217 >2C47-A nrPDB Length = 313 Score = 118 bits (295), Expect = 5e-27, Method: Composition-based stats. Identities = 50/286 (17%), Positives = 98/286 (34%), Gaps = 21/286 (7%) Query: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH-EN 70 +F++ +G G +G + + T E VAIK +EP L E + K E Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHL--EYRFYKQLSATEG 61 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRV--ISTQMLSDDHIQYFIYQTLRAVKVL 128 + ++ + ++ EL+ L + + + + + Q + ++ + Sbjct: 62 VPQVYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYV 116 Query: 129 HGSNVIHRDLKPSNLLINSNCD-----LKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 H ++I+RD+KP N L+ + + DFGLA+ + P + +T Sbjct: 117 HTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLT--- 173 Query: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPH 243 T Y + L + SR D+ + G + + G I T Sbjct: 174 GTARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKR 232 Query: 244 SDN-DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQR 288 + ++ C P + + + DL R Sbjct: 233 ATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 278 >4XHH-A nrPDB Length = 403 Score = 118 bits (295), Expect = 5e-27, Method: Composition-based stats. Identities = 49/224 (21%), Positives = 88/224 (39%), Gaps = 18/224 (8%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 + F++ +G G++G + T+ +GE VAI ++E L E ++ K+ Sbjct: 4 RVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDY--ESRVYKYLS 60 Query: 68 HENIITIFNIQRPDSFENFNEV-YIIQELMQTDLHRVIS--TQMLSDDHIQYFIYQTLRA 124 I F E ++ +L+ L + + + S + Q + Sbjct: 61 -----GGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICR 115 Query: 125 VKVLHGSNVIHRDLKPSNLLIN---SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 V+ +HG + IHRD+KP N L+ + V DFGL++ + P + +T Sbjct: 116 VQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLT- 174 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG 225 T Y + L + SR D+ S G +L + G Sbjct: 175 --GTARYASVNTHLG-IEQSRRDDLESLGYMLIYFCKGSLPWQG 215 >4XHL-A nrPDB Length = 394 Score = 115 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 47/224 (20%), Positives = 87/224 (38%), Gaps = 18/224 (8%) Query: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 + F++ +G G++G + T+ +GE VAI ++E L E ++ ++ Sbjct: 4 RVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDY--ESRVYRYLS 60 Query: 68 HENIITIFNIQRPDSFENFNEV-YIIQELMQTDLHRVIS--TQMLSDDHIQYFIYQTLRA 124 I F E ++ +L+ L + + + S + Q Sbjct: 61 -----GGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCR 115 Query: 125 VKVLHGSNVIHRDLKPSNLLIN---SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 ++ +HG + IHRD+KP N L+ + V DFGL++ + P + +T Sbjct: 116 IQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLT- 174 Query: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG 225 T Y + L + SR D+ S G +L + G Sbjct: 175 --GTARYASVNTHLG-IEQSRRDDLESLGYVLIYFCKGSLPWQG 215 >1CSN-A nrPDB Length = 298 Score = 111 bits (277), Expect = 6e-25, Method: Composition-based stats. Identities = 42/221 (19%), Positives = 83/221 (37%), Gaps = 20/221 (9%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH-ENI 71 +++ +GEG++GV+ T+ + VAIK R K+L N Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPN- 70 Query: 72 ITIFNIQRPDSFENFNEVYIIQELMQTDLHRV--ISTQMLSDDHIQYFIYQTLRAVKVLH 129 + F + ++ +L+ L + + + S + Q L V+ +H Sbjct: 71 VYYFG-------QEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIH 123 Query: 130 GSNVIHRDLKPSNLLINSNCD-----LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 ++++RD+KP N LI + V DFG+ + + P ++ ++ Sbjct: 124 EKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLS---G 180 Query: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPG 225 T Y + L + SR D+ + G + + G Sbjct: 181 TARYMSINTHLGREQ-SRRDDLEALGHVFMYFLRGSLPWQG 220 >5M07-A nrPDB Length = 276 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 40/220 (18%), Positives = 77/220 (35%), Gaps = 40/220 (18%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPF--DKPLFALRTLREIKILKHFKHEN 70 + + +LG A G V H A+K + P F R RE ++ H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 71 IITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQM---LSDDHIQYFIYQTLRAVK 126 I+ + + D +++I + + D + ++ + L + + A+ Sbjct: 92 ILEVHDRGEFD-----GQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALD 146 Query: 127 VLHGSNVIHRDLKPSNLLINS----NCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 H ++HRD+ P+N+++ S + + + DFG+A Sbjct: 147 YAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ--------------------- 185 Query: 183 VATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPI 222 Y APE + A D ++ LF P Sbjct: 186 ---PSYPAPE-LSAGADVDGRADQYALALTAIHLFAGAPP 221 >4L68-A nrPDB Length = 340 Score = 107 bits (268), Expect = 7e-24, Method: Composition-based stats. Identities = 55/285 (19%), Positives = 104/285 (36%), Gaps = 38/285 (13%) Query: 25 GVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFE 84 G A P G +A+K + L E+ L +H N+ + + Sbjct: 54 GTTYKALL-PDGSALAVKHLS--TCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVE--- 107 Query: 85 NFNEVYIIQELM-QTDLHRVISTQM--LSDDHIQYFIYQTLRAVKVLHGSN---VIHRDL 138 E +++ + M LH ++ + L R + LH ++H+++ Sbjct: 108 --EEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNI 165 Query: 139 KPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSA 198 S +LI+ + D ++ D GLAR++ S + S S MT + Y APE T+ Sbjct: 166 CSSVILIDEDFDARIIDSGLARLMVPSDNNES------SFMTGDLGEFGYVAPE-YSTTM 218 Query: 199 KYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRARE 258 S DV+ G +L EL G ++ L+ + + + E+ R + Sbjct: 219 LASLKGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFD-ENIRGKG 277 Query: 259 YIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 + + + + L + R P +R + +A Sbjct: 278 HDEEISKFVEIALNCVSSR----------------PKERWSMFQA 306 >5OAT-A nrPDB Length = 411 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 67/345 (19%), Positives = 112/345 (32%), Gaps = 94/345 (27%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPT-----GEIVAIKKIEPFDKPLFALRTLR------- 58 +D L + +G GVV SA K A+K + +D ++ L+ Sbjct: 11 NDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETV 70 Query: 59 --------------EIKILKHFKH----ENIITIFNIQR------------PDSFENFNE 88 EI++ KH NI+ IF++ P+ Sbjct: 71 PARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMS 130 Query: 89 VYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSN 148 ++++ + +L +ST S + Q L V + + HRDLK NLL++++ Sbjct: 131 LFLLMKRYDCNLQSFLSTAP-STRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTS 189 Query: 149 CD----LKVCDFG--LARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSA---- 198 L + DFG LA + + + + G T APE++ Sbjct: 190 EPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTAL------MAPEIICQKPGTFS 243 Query: 199 --KYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 YS D+W+ G I E+F F G Sbjct: 244 VLNYS-KADLWAVGAIAYEIFNCHNPFYGPSRLKNFN----------------------- 279 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 Y L K+ V L+ +L +P KR+ + Sbjct: 280 ---------YKEGDLPKLPDEVPTVIQALVANLLKRNPNKRLDPE 315 >4L00-A nrPDB Length = 304 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 54/311 (17%), Positives = 96/311 (30%), Gaps = 58/311 (18%) Query: 9 ISSDFQLKSLLGEGAYGVVCSAT------HKPTGEIVAIKKIEPFDKPLFA---LRTLRE 59 + D LG G + S T + T E IK I P L Sbjct: 23 LKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEA 82 Query: 60 IKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQT---DLHRVISTQMLSDDHIQY 116 +++ H++I+ ++ + D E +++E ++ DL + +L+ Sbjct: 83 ASMMRQVSHKHIVYLYGVCVRDV-----ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFK 137 Query: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 Q A+ L +++H ++ NLL+ D I S + Sbjct: 138 VAKQLASALSYLEDKDLVHGNVCTKNLLLAREG----IDSECGPFIKLSDPGIPITVLSR 193 Query: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL-FLRRPIFPGRDYRHQLLLI 235 E + + APE + S S A D WS G L E+ + + Sbjct: 194 QECIERIP---WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIE----- 245 Query: 236 FGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPA 295 +E P P K + DL+ R + +DP Sbjct: 246 ---------------------KERFYESRCRPVTPSCK-------ELADLMTRCMNYDPN 277 Query: 296 KRITAKEALEH 306 +R + + Sbjct: 278 QRPFFRAIMRD 288 >5USZ-A nrPDB Length = 289 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 45/329 (13%), Positives = 103/329 (31%), Gaps = 72/329 (21%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGE-------IVAIKKIEPFDKPLFALRTLREIKIL 63 D LG+G + + + G+ V +K ++ ++ ++ Sbjct: 8 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA-HRNYSESFFEAASMM 66 Query: 64 KHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQM--LSDDHIQYFIYQ 120 H++++ + + +E ++QE ++ L + ++ Q Sbjct: 67 SKLSHKHLVLNYGVCVCG-----DENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQ 121 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCD--------LKVCDFGLARIIDESAADNSEP 172 A+ L + +IH ++ N+L+ D +K+ D G++ + Sbjct: 122 LAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI 181 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 + PE + + A D WS G L E+ Sbjct: 182 P--------------WVPPECIENPKNLNLATDKWSFGTTLWEICSGG------------ 215 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 D L ++S R ++ + PA + +L+ + + Sbjct: 216 ------------DKPLSALDSQRKLQFYEDRHQLPAPK--------AAELANLINNCMDY 255 Query: 293 DPAKRITAKEALEHPYLQTYHDPNDEPEG 321 +P R + + + L + P+ P G Sbjct: 256 EPDHRPSFRAIIRD--LNSLFTPDLVPRG 282 >5UV4-A nrPDB Length = 311 Score = 99.3 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 49/213 (23%), Positives = 74/213 (34%), Gaps = 22/213 (10%) Query: 17 SLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFN 76 ++G +G AT G ++ +K ++ REIK L +H N++ + Sbjct: 31 EIIGRSCHGTSYKATL-DNGYMLTVKWLKEGFAKS-KKEFSREIKKLGSVRHPNLVPLRG 88 Query: 77 IQRPDSFENFNEVYIIQELMQTDLHRVIST------QMLSDDHIQYFIYQTLRAVKVLHG 130 + + I T L +S LS R + LH Sbjct: 89 YYWGP--KEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHN 146 Query: 131 SNVI-HRDLKPSNLLI-NSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY 188 VI H ++K SN+LI NS V D+ L R++ Y Sbjct: 147 ERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNA---------GALGY 197 Query: 189 RAPEVMLTSAKY-SRAMDVWSCGCILAELFLRR 220 PE TS S DV++ G IL EL + Sbjct: 198 SPPEFSSTSKPCPSLKSDVYAFGVILLELLTGK 230 >6EQI-C nrPDB Length = 433 Score = 98.5 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 60/352 (17%), Positives = 110/352 (31%), Gaps = 96/352 (27%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTG-----EIVAIKKIEPFDKPLFALRTL----RE-- 59 + L + +G VV SA K +A+K + +D + L RE Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 60 -------------IKILKHFK-----HENIITIFNIQ----------------------R 79 I+ + FK H NI+ ++++ Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 80 PDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLK 139 P+ ++++ + L + + + + Q L AV ++ N+ HRDLK Sbjct: 135 PEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLLEAVAHMNIHNISHRDLK 194 Query: 140 PSNLLINSNC-----DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 N+L++ + + + DFG N +S + R APE+ Sbjct: 195 SDNILVDLSEGDAYPTIVITDFGCCLC----DKQNGLVIPYRSEDQDKGGNRALMAPEIA 250 Query: 195 LTS-AKYS----RAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLR 249 +S + D+W+ G I E+F I P D ++ Sbjct: 251 NAKPGTFSWLNYKKSDLWAVGAIAYEIF--------------------NIDNPFYDKTMK 290 Query: 250 CIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 + E + LP + +L+ ML KR+ Sbjct: 291 LLSKSYKEEDLPELPDTIPFII-----------RNLVSNMLSRSTNKRLDCD 331 >3REP-A nrPDB Length = 271 Score = 92.7 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 44/284 (15%), Positives = 89/284 (31%), Gaps = 61/284 (21%) Query: 25 GVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKI--LKHFKHENIITIFNIQRPDS 82 G + + G + +K ++ D R E + L+ F H N++ + + Sbjct: 24 GELWKGRWQ--GNDIVVKVLKVRDWSTRKSRDFNE-ECPRLRIFSHPNVLPVLGACQSPP 80 Query: 83 FENFNEVYIIQELMQ-TDLHRVISTQ---MLSDDHIQYFIYQTLRAVKVLHGSN-VIHR- 136 + +I M L+ V+ ++ F R + LH +I R Sbjct: 81 APHPT---LITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRH 137 Query: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 L +++I+ + ++ + + P + + APE + Sbjct: 138 ALNSRSVMIDEDMTARIS-------MADVKFSFQSPGRMYA--------PAWVAPEALQK 182 Query: 197 SAKYS--RAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESP 254 + + R+ D+WS +L EL R F + + P Sbjct: 183 KPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPT----------- 231 Query: 255 RAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI 298 + P ++P L++ + DPAKR Sbjct: 232 -------------------IPPGISPHVSKLMKICMNEDPAKRP 256 >5C01-A nrPDB Length = 342 Score = 89.2 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 44/281 (15%), Positives = 84/281 (29%), Gaps = 49/281 (17%) Query: 30 ATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEV 89 + V +K ++P AL ++ H ++ + + E Sbjct: 101 GRDRGQELRVVLKVLDP-SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGP-----EN 154 Query: 90 YIIQELMQTD-LHRVISTQM--LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN 146 ++ E ++ L + + + Q A+ L N++H ++ N+L+ Sbjct: 155 IMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLA 214 Query: 147 SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAK-YSRAMD 205 + G + I S + E + + APE + A S AMD Sbjct: 215 RLGLAE----GTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMD 267 Query: 206 VWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPM 265 W G L E+ F G SP +E+ Sbjct: 268 KWGFGATLLEIC-----FDGE--------------------APLQSRSPSEKEHFYQRQH 302 Query: 266 YPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 P P+ L + L ++P +R + + L Sbjct: 303 RLPEP-------SCPQLATLTSQCLTYEPTQRPSFRTILRD 336 >4WOV-A nrPDB Length = 317 Score = 88.5 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 44/281 (15%), Positives = 84/281 (29%), Gaps = 49/281 (17%) Query: 30 ATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEV 89 + V +K ++P AL ++ H ++ + + E Sbjct: 78 GRDRGQELRVVLKVLDP-SHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGP-----EN 131 Query: 90 YIIQELMQTD-LHRVISTQM--LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN 146 ++ E ++ L + + + Q A+ L N++H ++ N+L+ Sbjct: 132 IMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLA 191 Query: 147 SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAK-YSRAMD 205 + G + I S + E + + APE + A S AMD Sbjct: 192 RLGLAE----GTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMD 244 Query: 206 VWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPM 265 W G L E+ F G SP +E+ Sbjct: 245 KWGFGATLLEIC-----FDGE--------------------APLQSRSPSEKEHFYQRQH 279 Query: 266 YPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 P P+ L + L ++P +R + + L Sbjct: 280 RLPEP-------SCPQLATLTSQCLTYEPTQRPSFRTILRD 313 >6J6I-B nrPDB Length = 351 Score = 86.5 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 32/201 (15%), Positives = 60/201 (29%), Gaps = 30/201 (14%) Query: 36 GEIVAIKKIEPFD---KPLFALRTLREIKILKHF-KHENIITIFNIQRPDSFENFNEVYI 91 IK+ + K +I + H N + + F + Sbjct: 81 DRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPV-----L 135 Query: 92 IQELMQTDLHRVI-------STQMLSDDHIQYFIYQTLRAVKVLHG---SNVIHRDLKPS 141 + E + +L + AV LH +IHRD+KP Sbjct: 136 VFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPM 195 Query: 142 NLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKY- 200 ++ ++ N K+ D + + E + + T Y P + + Sbjct: 196 HVFLDKNWTAKLSDLSFSISLPEGKSRIEAEW--------VLGTFGYIDP--LYHKTCFV 245 Query: 201 SRAMDVWSCGCILAELFLRRP 221 + DV+S G L + +P Sbjct: 246 TEYTDVYSFGICLLVIITGKP 266 >4I94-A nrPDB Length = 300 Score = 85.4 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 42/277 (15%), Positives = 92/277 (33%), Gaps = 51/277 (18%) Query: 26 VVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFEN 85 VV +A+K+ P + L E K + ++ + + D Sbjct: 44 VVYKGKL-ENQRRIAVKRFNRKSWPDSR-QFLEEAKAVGQLRNHRMANLLGCCYEDEERL 101 Query: 86 FNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSN-VIHRDLKPSNLL 144 ++ E + L +Q + +A++ ++ DL +L Sbjct: 102 LIAEFMPNETLAKHLFHW-ESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRVL 160 Query: 145 INSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAM 204 + + + ++ FGL + + + ++ + PE L + + + Sbjct: 161 FDDDANPRLSCFGLMKNSRDGKSYSTNLA--------------FTPPE-YLRTGRVTPES 205 Query: 205 DVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLP 264 ++S G +L +L + I P H L LI +++ Sbjct: 206 VIYSFGTLLLDLLSGKHIPP----SHALDLIRD-----------------------RNIQ 238 Query: 265 MYPAAPLEKMFPRVNPKGIDLLQ---RMLVFDPAKRI 298 M + LE F + G +L++ R L ++P +R Sbjct: 239 MLMDSGLEGQFS--SDDGTELIRLASRCLQYEPRERP 273 >5UU1-A nrPDB Length = 324 Score = 82.7 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 36/235 (15%), Positives = 80/235 (34%), Gaps = 29/235 (12%) Query: 10 SSDFQLKSLLGEGAYGVVCSAT-----HKPTGEIVAI------------KKIEPFDKPLF 52 + + L +G G +G++ A K +V + K + K Sbjct: 15 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDC 74 Query: 53 ALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI-STQMLSD 111 + + E K L + I +F F+ + +++ E + DL ++ Sbjct: 75 IKKWI-ERKQLDYLG----IPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKK 129 Query: 112 DHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLI--NSNCDLKVCDFGLARIIDESAADN 169 + + L ++ +H + +H D+K +NLL+ + + + D+GL+ + Sbjct: 130 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHK 189 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFP 224 + G T + + + SR DV G + + + Sbjct: 190 QYQENPRKGHN---GTIEFTSLDAH-KGVALSRRSDVEILGYCMLRWLCGKLPWE 240 >5CLR-A nrPDB Length = 451 Score = 81.5 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 51/262 (19%), Positives = 90/262 (34%), Gaps = 47/262 (17%) Query: 28 CSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFN 87 G+ +K ++ + L E L + + + Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLT--EFTNEKDTLSKLG-----RLVGTFFNEQTQVH- 147 Query: 88 EVYIIQELMQT-DLHRVISTQMLSDD-----HIQYFIYQTLRAVKVLHGSNVIHRDLKPS 141 YI+ ++ DL R + L+ + + + VK H +IHRDLKP Sbjct: 148 --YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPG 205 Query: 142 NLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV--MLTSAK 199 N++++++ + DFG + + + EP T Y APE+ Sbjct: 206 NIMLDADMQCHLVDFGSS-------SSDKEPKPASW------GTASYLAPELNAQEDFIA 252 Query: 200 YSRAMDVWSCGCILAELF--LRRPIFPGRD-----------YRHQLLLIFGIIGTPHSDN 246 +S+ D+++ L ELF R+ F D + I G++ S Sbjct: 253 FSQVSDLFALAYSLDELFNPFRQVKFAKVDIGIKNKHLVLLHAEIEACITGLMSNETSVR 312 Query: 247 DL---RCIESPRAREYIKSLPM 265 L R ++ R E KS P Sbjct: 313 TLYFSRILQLQRVPESFKSRPE 334 >2RSV-A nrPDB Length = 403 Score = 78.1 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 40/302 (13%), Positives = 102/302 (33%), Gaps = 28/302 (9%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIV------AIKK-----------IEPFDKPLFA 53 ++++ +G+G +G + A + E V +K ++ + + Sbjct: 42 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 100 Query: 54 LRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI--STQMLSD 111 + + I+ + K+ + + D + ++I + +DL ++ + + S Sbjct: 101 EQIQKWIRT-RKLKYLGVPKYWGSGLHDK-NGKSYRFMIMDRFGSDLQKIYEANAKRFSR 158 Query: 112 DHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN--SNCDLKVCDFGLARIIDESAADN 169 + + L ++ +H +H D+K SNLL+N + + + D+GLA Sbjct: 159 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 218 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 + T + + + A SR D+ G + + + Sbjct: 219 EYKEDPKRCHD---GTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKD 274 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 + + I + + + + + + M L+ + D+L + Sbjct: 275 PKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQG 334 Query: 290 LV 291 L Sbjct: 335 LK 336 >4IX6-A nrPDB Length = 350 Score = 77.3 bits (189), Expect = 8e-15, Method: Composition-based stats. Identities = 61/353 (17%), Positives = 110/353 (31%), Gaps = 71/353 (20%) Query: 3 KRIVYNISSDFQLK-SLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR-EI 60 +R D ++ LG G +G V K + V +K + A L E+ Sbjct: 11 RRTPGVEPKDIRVLPGPLGSGNFGTVFRGVFKGD-QDVVLK--NAKADVMAAEELLECEM 67 Query: 61 KILKHFKHEN----IITIFNIQRPDSFENFNEVY------------------IIQELMQT 98 + H H N + ++ E+Y ++ LM+ Sbjct: 68 DVNYHV-HANAKGTCARFMGCIELGA-KDGGEIYNGTLTEGLWLMWANEGENTVEALMRR 125 Query: 99 D---LHRVISTQMLSDDHI-QYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINS--NCDLK 152 L ++ ++ + + + + L ++ LH V+HRD+KP+NL+ LK Sbjct: 126 GTAPLATAMACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLK 185 Query: 153 VCDFGLARIIDESAADNSEPTGQQSGMTEYV-ATRWYRAP---------------EVMLT 196 + D G A + + G Y A Y P E Sbjct: 186 LIDLGAAALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKP 245 Query: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 D WS GC++ +L + + + G D + + Sbjct: 246 DRF-----DSWSAGCVMLQLAV--------------VGLRTDAGLERFLADYKAVGYDVN 286 Query: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 + Y + G DL QR++ + R + + AL H + Sbjct: 287 AFRGEKSGEYGTMDFAALDANGGA-GWDLCQRLMEAERDARASCEAALSHAFF 338 >2LAV-A nrPDB Length = 361 Score = 76.9 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 40/302 (13%), Positives = 102/302 (33%), Gaps = 28/302 (9%) Query: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIV------AIKK-----------IEPFDKPLFA 53 ++++ +G+G +G + A + E V +K ++ + + Sbjct: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 Query: 54 LRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI--STQMLSD 111 + + I+ + K+ + + D + ++I + +DL ++ + + S Sbjct: 94 EQIQKWIRT-RKLKYLGVPKYWGSGLHDK-NGKSYRFMIMDRFGSDLQKIYEANAKRFSR 151 Query: 112 DHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN--SNCDLKVCDFGLARIIDESAADN 169 + + L ++ +H +H D+K SNLL+N + + + D+GLA Sbjct: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHK 211 Query: 170 SEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYR 229 + T + + + A SR D+ G + + + Sbjct: 212 EYKEDPKRCHD---GTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDNLKD 267 Query: 230 HQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRM 289 + + I + + + + + + M L+ + D+L + Sbjct: 268 PKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQG 327 Query: 290 LV 291 L Sbjct: 328 LK 329 >4CI6-B nrPDB Length = 643 Score = 71.9 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 47/303 (15%), Positives = 96/303 (31%), Gaps = 59/303 (19%) Query: 33 KPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF-----KHENIITIFNIQRPDSFENFN 87 K +VA ++ + E++ KH KH N+ + + N Sbjct: 66 KDKQRLVA-----KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHG-MAVVPYGNRY 119 Query: 88 EVYIIQELMQT--------DLHRVISTQMLS----DDHIQYFIYQTLRAVKVLHGSNVIH 135 ++ + + L ++ I++ ++ L L + ++H Sbjct: 120 YYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVH 179 Query: 136 RDLKPSNLLIN-SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 D+KP N++ + ++ + V D GL + +P G T ++APE+ Sbjct: 180 NDIKPGNVVFDRASGEPVVIDLGL------HSRSGEQPKGF---------TESFKAPELG 224 Query: 195 LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESP 254 + + S DV+ +++ L F + I P D Sbjct: 225 VGNLGASEKSDVF---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMD------- 274 Query: 255 RAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHD 314 E + A +E + R + +L R + EA H +L Sbjct: 275 ---ENGYPIHRPGIAGVETAYTR-------FITDILGVSADSRPDSNEARLHEFLSDGTI 324 Query: 315 PND 317 + Sbjct: 325 DEE 327 >4O1O-A nrPDB Length = 717 Score = 70.8 bits (172), Expect = 9e-13, Method: Composition-based stats. Identities = 30/163 (18%), Positives = 68/163 (41%), Gaps = 23/163 (14%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 M ++ I ++++ A G + ++ + VA+K+ R +E+ Sbjct: 340 MIGKLKIFIDEEYKIADT----AEGGIYLGLYED--QEVAVKRFSEGST-----RGQQEV 388 Query: 61 KILKHFK-HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM------LSDDH 113 L+ + ++N++T + + S +++ L + L ++ D+ Sbjct: 389 SCLQSSRANDNVVTFYGSESDGSC-----LHVCLALCEYTLQEHLANHRGDAVPNEEDES 443 Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDF 156 + + +A+ LH S H+DL+P N+LI+S + DF Sbjct: 444 ARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF 486 Score = 30.7 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 6/36 (16%), Positives = 17/36 (47%), Gaps = 4/36 (11%) Query: 279 NPKGIDLLQRMLVF--DPAKRITAKEALEHPYLQTY 312 + + DL+ + + R+++ L HP+ ++ Sbjct: 538 DEETRDLIHHLFHPGDNVEDRLSS--LLAHPFFWSW 571 >6G4J-A nrPDB Length = 315 Score = 70.8 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 45/186 (24%), Positives = 71/186 (38%), Gaps = 30/186 (16%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENII 72 + L+ LG+GA G+V A G VA+K +L E+ +LK F Sbjct: 28 YTLRKQLGKGANGIVYLA-ETSDGH-VALKV------SDDSLSITSEVNVLKSFS----- 74 Query: 73 TIFNIQRPDSFENFNEVYII----------QELMQT-DLHRVISTQMLSDDHIQYFIYQT 121 ++ SF + ++ YI E ++ L + +S + + I + Q Sbjct: 75 KAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKG--AEWIPVLMIQL 132 Query: 122 LRAVKVLHGSNVIHRDLKPSNLLINS-NCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 L ++ VLH I DLKP NL++ ++ D G E A G Sbjct: 133 LSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG--GTTKEGRAIKEYTEFYDRGYW 190 Query: 181 EYVATR 186 Y TR Sbjct: 191 GY-GTR 195 >4OAU-C nrPDB Length = 699 Score = 66.5 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 29/164 (17%), Positives = 63/164 (38%), Gaps = 24/164 (14%) Query: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 M ++ + I +++ + G + + + VA+K R RE+ Sbjct: 337 MIGKLKFFIDEKYKIADT----SEGGIYLGFY--EKQEVAVKTFCEGS-----PRAQREV 385 Query: 61 KILKHFK-HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDH------ 113 L+ + + +++T + S + +++ L + L + D Sbjct: 386 SCLQSSRENSHLVTFYG-----SESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEF 440 Query: 114 IQYFIYQTLRAVKVLH-GSNVIHRDLKPSNLLINSNCDLKVCDF 156 + + +AV+ LH H+DL+P N+LI+S + DF Sbjct: 441 ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 484 Score = 29.2 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 8/34 (23%), Positives = 15/34 (44%) Query: 279 NPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTY 312 + + DL+ R+ R + L HP+ T+ Sbjct: 536 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTW 569 >5DMZ-A nrPDB Length = 365 Score = 65.7 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 43/231 (18%), Positives = 90/231 (38%), Gaps = 29/231 (12%) Query: 11 SDFQLKSLL-------GEGAYGVVCSAT-----HKPTGEIVAIKKIEPFDKPLFALRTLR 58 ++FQL S L GEGA+ V AT + +K KP Sbjct: 58 TEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKV----QKPANPWEFYI 113 Query: 59 EIKILKHFK---HENIITIFNIQR-PDSFENFNEVYIIQELMQT-DLHRVISTQMLSDDH 113 ++++ K + ++ + E+Y L+ +L++ +++ Sbjct: 114 GTQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGL 173 Query: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDF-----GLARIIDESAAD 168 + F + L ++ +H +IH D+KP N ++ N L+ D GLA +ID + Sbjct: 174 VISFAMRMLYMIEQVHDCEIIHGDIKPDNFIL-GNGFLEQDDEDDLSAGLA-LIDLGQSI 231 Query: 169 NSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLR 219 + + + + T T ++ E ML++ ++ +D + + + Sbjct: 232 DMKLFPKGTIFTAKCETSGFQCVE-MLSNKPWNYQIDYFGVAATVYCMLFG 281 >5GZA-A nrPDB Length = 290 Score = 62.7 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 38/227 (16%), Positives = 78/227 (34%), Gaps = 35/227 (15%) Query: 2 PKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIK 61 P I S + L+G+GA V + + G+ VA + +A L + Sbjct: 16 PWLKCPEIRSGVRRVKLIGQGAVKKVYLSEWQ--GQKVA---LSVLSSDQYADDFLHGLS 70 Query: 62 ILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTD----LHRVISTQMLSDDHIQYF 117 +L+ + +++T+ + D+ + E L ++ + + + Sbjct: 71 MLRALQSSHVVTLVGVCEEDAV-------FVTEYHPLGSVLTLDTTLAQERYRWRNSWHT 123 Query: 118 IYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLK-VCDFGLARIIDESAAD-NSEPTGQ 175 Q A+ + +H ++ +SN K + F LA + A D ++ P + Sbjct: 124 RLQL--AIDYVAFLAYLHSSPAGIRVMCDSNDLHKTLSQFLLASDMRLLANDLDALPEVE 181 Query: 176 QSGMTEYVA----TRWYRAPEVMLTSA-----------KYSRAMDVW 207 + G+ T + APE + Y D+W Sbjct: 182 KGGLGVKCGHHELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >6BHC-A nrPDB Length = 438 Score = 61.5 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 46/295 (15%), Positives = 86/295 (29%), Gaps = 64/295 (21%) Query: 39 VAIKKIEPFDKPLF--------ALRTLREIKILKHFKH-----ENIITIFNIQRPDSFEN 85 A+K + K I + H N + + P + Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN--RLLPWEDPSKKQR 143 Query: 86 FNEVYIIQE--------LMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRD 137 + V I +E ++ L + + L + + + Q ++ L +V H D Sbjct: 144 SHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCD 203 Query: 138 LKPSNLLINSNCDLKVC-DFGLARIIDESAADNS---EPTGQQSGMTEYVATRWYR---- 189 L+ NLL+ FG A S+ Q + V R Sbjct: 204 LRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSR 263 Query: 190 -APEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 APE++ + + D + G ++ E+ F Sbjct: 264 LAPEIITATQY--KKCDEFQTGILIYEMLHLPNPFD------------------------ 297 Query: 249 RCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEA 303 E+P +E + P P + + L +L +P++RI +A Sbjct: 298 ---ENPELKEREYTRADLPRIPFRSPY---SRGLQQLASCLLNPNPSERILISDA 346 >2JII-A nrPDB Length = 352 Score = 61.1 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 28/221 (12%), Positives = 65/221 (29%), Gaps = 17/221 (7%) Query: 78 QRPDSFENFNEVYIIQELMQTDL---HRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVI 134 +++ + L V +LS+ + + L A++ LH + + Sbjct: 122 CMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYV 181 Query: 135 HRDLKPSNLLIN--SNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPE 192 H ++ N+ ++ + + +G A S + G +S + + + + Sbjct: 182 HGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDL---EFISMD 238 Query: 193 VMLTSAKYSRAMDVWSCGCILAELFLRRPIF-----PGRDYRHQLLLIFGIIGT---PHS 244 + SR D+ S G + + + D Q G P Sbjct: 239 LHKGCGP-SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCG 297 Query: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDL 285 + + + +L P + + DL Sbjct: 298 HWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDL 338 >6EAS-A nrPDB Length = 308 Score = 57.3 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 34/261 (13%), Positives = 71/261 (27%), Gaps = 51/261 (19%) Query: 49 KPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS--- 105 + ++I L H+N + + + F V + + L + Sbjct: 81 SKENESQYRKKITNLSKVSHKNFMNLLGYCEEE--HPFTRVMVFEYAPNGTLFEHLHVRE 138 Query: 106 TQMLSDDHIQYFIYQTLRAVKVLHGSNV--IHRDLKPSNLLINSNCDLKVCDFGLARIID 163 + L ++ +H R+ + + + + KV D Sbjct: 139 AEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDL----EFW 194 Query: 164 ESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIF 223 A ++ T + + + E ++ G +L E+ R Sbjct: 195 NDAKGHNSTTNNELAFSPDM--------EDIVRK-----------YGMVLLEILTGRVPS 235 Query: 224 PGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI 283 D P + R E E + P FP + + Sbjct: 236 SEDD-------------GPLENWVSRYFEGGMRLEELID-------PSIGFFPEDTARAL 275 Query: 284 -DLLQRMLVFDPAKRITAKEA 303 ++++ + DP KR KE Sbjct: 276 CEVVRSCIDRDPKKRPQMKEV 296 >4CYJ-A nrPDB Length = 438 Score = 57.3 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 28/154 (18%), Positives = 58/154 (37%), Gaps = 33/154 (21%) Query: 24 YG---VVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKIL------KHFKHENIITI 74 +G V A + G A++++E + R E IL K K+ +I+TI Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRLEGY-------RLTNEKAILNVMKDWKKIKNASIVTI 117 Query: 75 FNIQRPDSFENFNEVYIIQELMQTDLHRVISTQML--------------SDDHIQYFIYQ 120 + F + + +I L + + ++ I +I Q Sbjct: 118 HEVFTTREFGDSS---LIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQ 174 Query: 121 TLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVC 154 A+K +H + + R L+PS +++ +++ Sbjct: 175 IANALKTIHSNRLAARCLEPSKIILTDINRIRLS 208 >6M7Z-A nrPDB Length = 319 Score = 56.9 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 40/244 (16%), Positives = 80/244 (32%), Gaps = 63/244 (25%) Query: 90 YIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNC 149 YI L + + ++ T S +Q + A+K LH ++HR ++ ++ + + Sbjct: 123 YIFHPLSKGLVGDMLETGR-SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDG 181 Query: 150 DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV--------MLTSAKYS 201 + + A I GQ++ APE+ LT +++ Sbjct: 182 TVVLGGLDTAAPIGTETRLWVGFFGQET------------APEIDRNFLADLALTQGRHT 229 Query: 202 RAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIK 261 DV+S G + ++G + + R E + Sbjct: 230 VKSDVYSLGV-------------------AFRNLVQLLGNGNLGPEDRGAVRQDHLELLD 270 Query: 262 SLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPNDEPEG 321 L Q+M+ +P R T +E ++ P + + + E EG Sbjct: 271 K----------------------LSQKMIEEEPGNRPTIEEIMKDPLFEGLNFEDIE-EG 307 Query: 322 EPIP 325 + P Sbjct: 308 KARP 311 >5GZ9-A nrPDB Length = 305 Score = 55.7 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 40/226 (17%), Positives = 75/226 (33%), Gaps = 46/226 (20%) Query: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKH 68 + ++ + +GEGA V + K VA + + L +++LK + Sbjct: 32 LRTEVRQLKRVGEGAVKRVFLSEWKE--HKVA---LSRLTRLEMKEDFLHGLQMLKSLQS 86 Query: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQ-TDLHRVISTQMLS-------DDHIQYFIYQ 120 E+++T+ D I+ E L + T LS H + Sbjct: 87 EHVVTLVGYCEEDGT-------ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAME 139 Query: 121 TLRAVKVLHGSNVIHRDLKPSN--------LLINSNCDLKVCDFGLARIIDESAADNSEP 172 + + LH S + R + SN L+ SN + D A + + + Sbjct: 140 YVSIINYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLD-ALPLVDHDSGVLIK 198 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSA-----------KYSRAMDVW 207 G + ++V APE + Y+ +D+W Sbjct: 199 CGHRELHGDFV------APEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >6EWX-A nrPDB Length = 484 Score = 55.3 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 42/254 (16%), Positives = 70/254 (27%), Gaps = 86/254 (33%) Query: 94 ELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLI-------- 145 + ++ + + + + + + + Q ++ L +IHRDL NLL+ Sbjct: 192 DFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSS 251 Query: 146 ---------------------------------NSNCDLKVCDFGLARIIDESAADNSEP 172 L + +F A+ + + Sbjct: 252 PGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQK 311 Query: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 Q APE++ S R D + G ++ EL Sbjct: 312 KSQAR-----------LAPEIVSASQY--RKFDEFQTGILIYELL--------------- 343 Query: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIK-SLPMYPAAPLEKMFPRVNPKGIDLLQRMLV 291 H N R R+Y + LP P L +P L +L Sbjct: 344 ----------HQPNPFEVRAQLRERDYRREDLPPLPTLSLY------SPGLQQLAHLLLE 387 Query: 292 FDPAKRITAKEALE 305 DP KRI EA Sbjct: 388 ADPIKRIRIGEAKR 401 >3ENH-A nrPDB Length = 540 Score = 53.0 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 37/152 (24%), Positives = 63/152 (41%), Gaps = 24/152 (15%) Query: 18 LLGEGAYGVVCSATHKPTGEIVAIK-KIEPF------DKPLFALRTLREIKILKHFKHEN 70 L+G+GA + V IK +++ D+ + RT RE + L Sbjct: 343 LIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLA------ 394 Query: 71 IITIFNIQRPDSFE-NFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 ++ F I P F+ + + I+ + L + + L Y+ V LH Sbjct: 395 LVKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDVIEDNLD------IAYKIGEIVGKLH 448 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARI 161 ++VIH DL SN + + + L + DFGL +I Sbjct: 449 KNDVIHNDLTTSNFIFDKD--LYIIDFGLGKI 478 >4AZV-A nrPDB Length = 569 Score = 51.1 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 24/142 (16%), Positives = 48/142 (33%), Gaps = 23/142 (16%) Query: 24 YGV--VCS--ATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH----FKHENIITIF 75 +G VC P G + + EIK L F ++ Sbjct: 258 FGEDYVCKFFYYDMPHG------ILTAEESQRNKYELHNEIKFLTQPPAGFDAPAVLA-- 309 Query: 76 NIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIH 135 EN +++ E + L + + + + LR++ L H Sbjct: 310 ------HGENAQSGWLVMEKLPGRLLSDMLAAG-EEIDREKILGSLLRSLAALEKQGFWH 362 Query: 136 RDLKPSNLLINSNCDLKVCDFG 157 D++P N+++++ ++ DFG Sbjct: 363 DDVRPWNVMVDARQHARLIDFG 384 >4AZW-A nrPDB Length = 471 Score = 51.1 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 24/142 (16%), Positives = 48/142 (33%), Gaps = 23/142 (16%) Query: 24 YGV--VCS--ATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKH----FKHENIITIF 75 +G VC P G + + EIK L F ++ Sbjct: 258 FGEDYVCKFFYYDMPHG------ILTAEESQRNKHELHNEIKFLTQPPAGFDAPAVLA-- 309 Query: 76 NIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIH 135 EN +++ E + L + + + + LR++ L H Sbjct: 310 ------HGENAQSGWLVMEKLPGRLLSDMLAAG-EEIDREKILGSLLRSLAALEKKGFWH 362 Query: 136 RDLKPSNLLINSNCDLKVCDFG 157 D++P N+++++ ++ DFG Sbjct: 363 DDVRPWNVMVDARQHARLIDFG 384 >5VE6-A nrPDB Length = 492 Score = 50.7 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 18/35 (51%) Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLI 145 + + + + Q ++ L +IHRDL NLL+ Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 33.4 bits (75), Expect = 0.17, Method: Composition-based stats. Identities = 29/118 (24%), Positives = 38/118 (32%), Gaps = 34/118 (28%) Query: 189 RAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDL 248 APE++ S R D + G ++ EL H N Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELL-------------------------HQPNPF 357 Query: 249 RCIESPRAREY-IKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALE 305 R R+Y + LP PA L +P L +L DP KRI EA Sbjct: 358 EVRAQLRERDYRQEDLPPLPALSLY------SPGLQQLAHLLLEADPIKRIRIGEAKR 409 >4BWP-A nrPDB Length = 448 Score = 47.6 bits (112), Expect = 7e-06, Method: Composition-based stats. Identities = 25/165 (15%), Positives = 54/165 (32%), Gaps = 40/165 (24%) Query: 28 CSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFN 87 ATH TG +++I F TL E + K +H N++ + + +F + N Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTLVE--MWKKLQHTNVVQLREVFTTKAFGD-N 123 Query: 88 EVYIIQELMQTD---------------------------------LHRVISTQMLSDDHI 114 + ++ + + R + +L + I Sbjct: 124 SLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATI 183 Query: 115 QYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSN----CDLKVCD 155 I Q +K +H + + + L P+ +++ + D Sbjct: 184 WSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >6R5K-O nrPDB Length = 689 Score = 47.6 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 18/135 (13%), Positives = 50/135 (37%), Gaps = 9/135 (6%) Query: 28 CSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFN 87 G+ +K++ DK + + + +I N+I +I + F + + Sbjct: 311 FKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDLS 370 Query: 88 EVYIIQELMQTDLHRV------ISTQMLSDDHIQYFIYQTLRAVKVLHGSNV-IHRDLKP 140 + ++ + L ++++++ ++ Q + +H N+ I L Sbjct: 371 -ICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLNW 429 Query: 141 SNLLINSN-CDLKVC 154 +LI + +K+ Sbjct: 430 RKVLITGDPGRIKLS 444 >6G38-A nrPDB Length = 357 Score = 47.3 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 31/177 (17%), Positives = 53/177 (29%), Gaps = 45/177 (25%) Query: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-------PFDKPLFALRTLREIKI 62 + Q +GEG +G V T VAIK I L EI I Sbjct: 40 TEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQKTFEEILPEIII 97 Query: 63 LKHF---------KHENIITIFNIQ-------------------------RPDSFENFNE 88 K + E I + ++ F ++ Sbjct: 98 SKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQ 157 Query: 89 VYIIQELMQTDLH-RVISTQMLSDDHIQYFIYQTLRAVKVLH-GSNVIHRDLKPSNL 143 ++I+ E + + T++ S + ++Q ++ V HRDL N+ Sbjct: 158 LFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >4XR7-L nrPDB Length = 465 Score = 45.7 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 18/135 (13%), Positives = 50/135 (37%), Gaps = 9/135 (6%) Query: 28 CSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFN 87 G+ +K++ DK + + + +I N+I +I + F + + Sbjct: 87 FKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDLS 146 Query: 88 EVYIIQELMQTDLHRV------ISTQMLSDDHIQYFIYQTLRAVKVLHGSNV-IHRDLKP 140 + ++ + L ++++++ ++ Q + +H N+ I L Sbjct: 147 -ICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLNW 205 Query: 141 SNLLINSN-CDLKVC 154 +LI + +K+ Sbjct: 206 RKVLITGDPGRIKLS 220 >4CZY-B nrPDB Length = 429 Score = 43.0 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 25/145 (17%), Positives = 58/145 (40%), Gaps = 26/145 (17%) Query: 28 CSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKIL------KHFKHENIITIFNIQRPD 81 A + G A+++IE + R E IL K + NI+T+ + Sbjct: 61 YKAQNNKNGRHFALRRIEGY-------RLTNEKAILNVTKEWKKIINANIVTVHEAFTTE 113 Query: 82 SFENFNEVYII------QELMQTDL------HRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 F + + +++ + L +R+ +T + ++ + ++ Q A+ +H Sbjct: 114 FFGDSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIH 173 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVC 154 + + R L+ S + I N +++ Sbjct: 174 NAKLAARCLELSKI-IWENNRIRLA 197 >4WWA-A nrPDB Length = 261 Score = 43.0 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 31/152 (20%), Positives = 58/152 (38%), Gaps = 25/152 (16%) Query: 28 CSATHKPTGEIVAIKKIEPF-------DKPLFALRTLREIKILKHFKHENIITIFNIQRP 80 K + + IK P D+ L RTL E ++L +I + + Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKL---YLIPGLCVPQL 94 Query: 81 DSFENFNEVYIIQELMQTDL---HRVISTQMLSDDH--------IQYFIYQTLRAVKVLH 129 + + +N +I E + DL H + + H + + + R + +LH Sbjct: 95 IACDPYNG-FIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLH 153 Query: 130 GSNVIHRDLKPSNLLINSNC---DLKVCDFGL 158 ++ H DL SN+++ + + DFGL Sbjct: 154 WNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >3DZO-A nrPDB Length = 413 Score = 41.5 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 48/277 (17%), Positives = 89/277 (32%), Gaps = 70/277 (25%) Query: 1 MPKRIVYNISSDFQLKSLLGE-------GAYGVVC---------SATHKPTGEIV----- 39 + ++N F+++S LGE G V AT + TGE Sbjct: 55 LVSTSLWNTGQPFRVESELGERPRTLVRG---TVLGQEDPYAYLEATDQETGESFEVHVP 111 Query: 40 ---------AIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNE-- 88 AIK+++ + + LR LR IK K K + + I D ++ + Sbjct: 112 YFTERPPSNAIKQMK---EEVLRLRLLRGIKNQKQAK----VHLRFIFPFDLVKDPQKKK 164 Query: 89 ------------------VYIIQE-----LMQTDLHRVISTQMLSDDHIQYFIYQTLRAV 125 +Y + + L + + L Q +R + Sbjct: 165 MIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLL 224 Query: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 LH ++H L+P +++++ + + F + A P G+ E A Sbjct: 225 ASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF---EHLVRDGASAVSPIGRGFAPPETTAE 281 Query: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPI 222 R P + A D W+ G + ++ Sbjct: 282 R--MLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLP 316 >3BYV-A nrPDB Length = 377 Score = 41.1 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 46/283 (16%), Positives = 91/283 (32%), Gaps = 81/283 (28%) Query: 1 MPKRIVYNISSDFQLKSLLGE-------GAYGVVC---------SATHKPTGEIV----- 39 + ++N F+++S LGE G V AT + TGE Sbjct: 50 LVSTSLWNTGQPFRVESELGERPRTLVRG---TVLGQEDPYAYLEATDQETGESFEVHVP 106 Query: 40 ---------AIKKIEPFDKPLFALRTLREIKILKHFK-H---------------ENIITI 74 AIK+++ + + LR LR IK K K H + +I + Sbjct: 107 YFTERPPSNAIKQMK---EEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRV 163 Query: 75 FNIQRPDSFENFNEVYIIQE-----LMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLH 129 +R + +Y + + L + + L Q +R + LH Sbjct: 164 RLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLH 223 Query: 130 GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYR 189 ++H L+P +++++ + + F E + +R + Sbjct: 224 HYGLVHTYLRPVDIVLDQRGGVFLTGF--------------EHLVRDGARVVSSVSRGFE 269 Query: 190 APEVMLTSAKY----------SRAMDVWSCGCILAELFLRRPI 222 PE+ A + + D W+ G ++ ++ Sbjct: 270 PPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLP 312 >1TQM-A nrPDB Length = 282 Score = 40.7 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 26/158 (16%), Positives = 53/158 (33%), Gaps = 31/158 (19%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEIVA---------IKKIEPFDKPLF-------ALRTLR 58 + L+GEG V + + GE V KK++ Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 59 EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFI 118 E + L+ + + P + ++ EL+ D + ++ + D + Sbjct: 154 EFRALQKLQ--------GLAVPKVYAWEGNA-VLMELI--DAKELYRVRVENPDEVLDM- 201 Query: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDF 156 L V + ++H DL N+L++ + + DF Sbjct: 202 --ILEEVAKFYHRGIVHGDLSQYNVLVSEEG-IWIIDF 236 >3Q60-A nrPDB Length = 371 Score = 39.6 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 44/245 (17%), Positives = 80/245 (32%), Gaps = 45/245 (18%) Query: 81 DSFENFNEVYII------QELMQTDLHRVISTQMLSDDHIQYFI-YQTLRAVKVLHGSNV 133 D + N + ++ EL+ + L V + + + Q +R L + Sbjct: 156 DDYAVANYLLLMPAASVDLELLFSTLDFVYVFRGDEGILALHILTAQLIRLAANLQSKGL 215 Query: 134 IHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV 193 +H P NL I + L + D G + + T Y E Sbjct: 216 VHGHFTPDNLFIMPDGRLMLGD-----------VSALWKVGTRGPASSVPVT--YAPREF 262 Query: 194 MLTSA-KYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIE 252 + S ++ A++ W G + ++ F L+ GI G+ + Sbjct: 263 LNASTATFTHALNAWQLGLSIYRVWCLFLPFG--------LVTPGIKGSWKRPSLRVPGT 314 Query: 253 SPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP-YLQT 311 A LP + L+ R L FD +R+ EA+E P +LQ Sbjct: 315 DSLAFGSCTPLPDFVKT---------------LIGRFLNFDRRRRLLPLEAMETPEFLQL 359 Query: 312 YHDPN 316 ++ + Sbjct: 360 QNEIS 364 >6FAI-l nrPDB Length = 425 Score = 38.8 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 29/193 (15%), Positives = 60/193 (31%), Gaps = 40/193 (20%) Query: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKK-----------------IEPFDK-----P 50 + + + +G G + + K V +K ++ ++ Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 51 LFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLS 110 L L +E + + + + P+ F+N + ++ EL++ R + Sbjct: 154 LSRLAANKEYQFMSMLYSK------GFKVPEPFDNSRHI-VVMELIEGYPMRRLRKH--- 203 Query: 111 DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINS------NCDLKVCDFGLARIIDE 164 +I + + L S +IH D N++I +C V DF I Sbjct: 204 -KNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQH 262 Query: 165 SAADNSEPTGQQS 177 AD Sbjct: 263 QDADYYFQRDVDC 275 >2W1Z-A nrPDB Length = 368 Score = 37.2 bits (85), Expect = 0.011, Method: Composition-based stats. Identities = 45/273 (16%), Positives = 90/273 (32%), Gaps = 62/273 (22%) Query: 1 MPKRIVYNISSDFQLKSLLGE--------------GAYGVVCSATHKPTGEIV------- 39 + ++ F+++S LGE G+Y + AT + TGE + Sbjct: 35 LVSTALWRNEQSFRVESELGERPRTLVRGPVLRDDGSY-ICLEATDQETGEPLEVHVPYF 93 Query: 40 -------AIKK-------------IEPFDKPLFALRTLREIKILKHFKHENIITIFNIQR 79 AIK+ I+ + LR + I ++K K +I + +R Sbjct: 94 TERPPSNAIKQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDER 153 Query: 80 PDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIY-----QTLRAVKVLHGSNVI 134 + +Y + L V+ + + + + Q +R L ++ Sbjct: 154 DMWVLSRFFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLV 213 Query: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 H D + N+L++ + + F + A P G+ E A E M Sbjct: 214 HADFQVRNILLDQRGGVFLTGF---EHLVRDGASAVSPIGRGFAPPETTA-------ERM 263 Query: 195 LTSAKY-----SRAMDVWSCGCILAELFLRRPI 222 L ++ + D W+ G + ++ Sbjct: 264 LPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLP 296 >5YK0-A nrPDB Length = 452 Score = 36.5 bits (83), Expect = 0.020, Method: Composition-based stats. Identities = 26/169 (15%), Positives = 49/169 (28%), Gaps = 39/169 (23%) Query: 25 GVVCSATHKPTGEIVAIKKIEPFDKPLFALRT---LREIKILKHF----KHENII----- 72 G V A G VA+K P R + +LK + ++ Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 73 --------TI---------FNIQRPDSFENFNEV-----YIIQELMQTDLHRVISTQMLS 110 + F+ + V +IQE ++ I + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTT 264 Query: 111 DDHIQYFIYQTLRAVKV--LHGSNVIHRDLKPSNLLINSNCDLKVCDFG 157 + + I L + ++H D P N ++ + + + DFG Sbjct: 265 EQ--RDLIGTLLAELTFDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >4BVU-A nrPDB Length = 211 Score = 35.7 bits (81), Expect = 0.033, Method: Composition-based stats. Identities = 24/143 (16%), Positives = 50/143 (34%), Gaps = 14/143 (9%) Query: 15 LKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITI 74 L L+G+G+ + + + KK + EI + + E Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY---KKYDLIGNQ------YNEILEMAWQESELFNAF 94 Query: 75 FNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVI 134 + + + +VY+ + I T + D+ ++ + L+ ++I Sbjct: 95 YGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICK----LNELSII 150 Query: 135 HRDLKPSNLLINSNCD-LKVCDF 156 H DL N+L + + L DF Sbjct: 151 HYDLNTGNMLYDKESESLFPIDF 173 >4ZO4-A nrPDB Length = 204 Score = 35.3 bits (80), Expect = 0.039, Method: Composition-based stats. Identities = 22/88 (25%), Positives = 37/88 (42%), Gaps = 5/88 (5%) Query: 33 KPTGEIV-----AIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFN 87 K GEIV A K +E F P + L +++IL + I ++EN Sbjct: 72 KILGEIVFNNKEAKKILENFTHPKIRAKILEQMQILDKENKAFFVEIPLFFESGAYENLG 131 Query: 88 EVYIIQELMQTDLHRVISTQMLSDDHIQ 115 +V +I + L R++ LS + + Sbjct: 132 KVIVIYTPKELSLKRIMQRDKLSLEAAK 159 >6G18-v nrPDB Length = 552 Score = 33.0 bits (74), Expect = 0.18, Method: Composition-based stats. Identities = 13/72 (18%), Positives = 31/72 (43%), Gaps = 4/72 (5%) Query: 85 NFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLL 144 ++N ++ EL+ + + + D Y + + + L +IH D NL+ Sbjct: 180 DYNRHAVVMELING--YPLCQIHHVEDPASVY--DEAMELIVKLANHGLIHGDFNEFNLI 235 Query: 145 INSNCDLKVCDF 156 ++ + + + DF Sbjct: 236 LDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 32.2 bits (72), Expect = 0.38, Method: Composition-based stats. Identities = 13/72 (18%), Positives = 31/72 (43%), Gaps = 4/72 (5%) Query: 85 NFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLL 144 ++N ++ EL+ + + + D Y + + + L +IH D NL+ Sbjct: 180 DYNRHAVVMELING--YPLCQIHHVEDPASVY--DEAMELIVKLANHGLIHGDFNEFNLI 235 Query: 145 INSNCDLKVCDF 156 ++ + + + DF Sbjct: 236 LDESDHITMIDF 247 >6EF6-A nrPDB Length = 354 Score = 29.9 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 18/28 (64%), Gaps = 3/28 (10%) Query: 132 NVIHRDLKPSNLLINSN---CDLKVCDF 156 +IH DL+ +NLL++S+ + V DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >6GML-W nrPDB Length = 584 Score = 29.9 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 12/60 (20%), Positives = 24/60 (40%), Gaps = 1/60 (1%) Query: 46 PFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS 105 D L L EI H ++ + ++ ++ + +V EL +T L R++ Sbjct: 438 QTDHTPVHLALLDEISTCHQLLHPQVLQLL-VKLFETEHSQLDVMEQLELKKTLLDRMVH 496 >5L3X-B nrPDB Length = 405 Score = 29.9 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 12/60 (20%), Positives = 24/60 (40%), Gaps = 1/60 (1%) Query: 46 PFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS 105 D L L EI H ++ + ++ ++ + +V EL +T L R++ Sbjct: 259 QTDHTPVHLALLDEISTCHQLLHPQVLQLL-VKLFETEHSALDVMEQLELKKTLLDRMVH 317 >4WGK-A nrPDB Length = 688 Score = 29.9 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 10/47 (21%), Positives = 23/47 (48%), Gaps = 6/47 (12%) Query: 103 VISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNC 149 VI+++ S+ Q+ + L+++ + H ++KP + IN Sbjct: 111 VIASEGFSNQTFQHMVTGILKSID------IAHTNMKPGKIFINKGN 151 >4ESA-B nrPDB Length = 146 Score = 29.5 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 10/42 (23%), Positives = 21/42 (50%), Gaps = 3/42 (7%) Query: 22 GAYGVVCSATHKPTGEIVA---IKKIEPFDKPLFALRTLREI 60 G++G + +A + VA IK + D+ + + ++EI Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEI 84 >6MRG-A nrPDB Length = 580 Score = 28.4 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 21/48 (43%), Gaps = 5/48 (10%) Query: 21 EGAYGVVC-----SATHKPTGEIVAIKKIEPFDKPLFALRTLREIKIL 63 +G +G + A G VA++ + + LR +RE++ L Sbjct: 525 KGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQL 572 >3AOI-E nrPDB Length = 99 Score = 28.4 bits (62), Expect = 5.3, Method: Composition-based stats. Identities = 13/72 (18%), Positives = 32/72 (44%), Gaps = 7/72 (9%) Query: 286 LQRML-VFDPAKRIT------AKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEAL 338 + ++ + D R+T A++ L H + T +P + P+ + + F + + A+ Sbjct: 6 IDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAVTWAM 65 Query: 339 TTKDLKKLIWNE 350 +L++ E Sbjct: 66 KELLTGRLVFGE 77 >6MC8-A nrPDB Length = 308 Score = 28.0 bits (61), Expect = 6.4, Method: Composition-based stats. Identities = 15/64 (23%), Positives = 27/64 (42%), Gaps = 5/64 (7%) Query: 124 AVKVL-HGSNVIHRDLKPSNL--LINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMT 180 + L H + +IH D PS++ L++ ++ D G AR I + A P + Sbjct: 83 GLLHLQHSARLIHTDGVPSDIALLVDGAPRAQLSD-G-ARAIAGTYASMQAPGPEGRSEW 140 Query: 181 EYVA 184 + Sbjct: 141 GILP 144 >1HQM-E nrPDB Length = 99 Score = 28.0 bits (61), Expect = 6.4, Method: Composition-based stats. Identities = 12/72 (16%), Positives = 30/72 (41%), Gaps = 7/72 (9%) Query: 286 LQRML-VFDPAKRIT------AKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEAL 338 + ++ + D R+T A++ L H + T +P + P+ + + + + A+ Sbjct: 6 IDKLFGMVDSKYRLTVVVAKRAQQLLRHRFKNTVLEPEERPKMRTLEGLYDDPNAVTWAM 65 Query: 339 TTKDLKKLIWNE 350 +L + E Sbjct: 66 KELLTGRLFFGE 77 >6GL3-A nrPDB Length = 386 Score = 27.6 bits (60), Expect = 7.4, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 19/42 (45%), Gaps = 2/42 (4%) Query: 142 NLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 N+L+++ + DFG I+ S + T TE+V Sbjct: 264 NILLDAEGHIIHIDFGF--ILSSSPRNLGFETSAFKLTTEFV 303 >4D0L-A nrPDB Length = 566 Score = 27.6 bits (60), Expect = 7.4, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 19/42 (45%), Gaps = 2/42 (4%) Query: 142 NLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 N+L+++ + DFG I+ S + T TE+V Sbjct: 443 NILLDAEGHIIHIDFGF--ILSSSPRNLGFETSAFKLTTEFV 482 >5C4G-E nrPDB Length = 529 Score = 27.6 bits (60), Expect = 8.2, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 19/42 (45%), Gaps = 2/42 (4%) Query: 142 NLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 N+L+++ + DFG I+ S + T TE+V Sbjct: 406 NILLDAEGHIIHIDFGF--ILSSSPRNLGFETSAFKLTTEFV 445 >6DFL-A nrPDB Length = 259 Score = 27.2 bits (59), Expect = 9.7, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 23/55 (41%) Query: 105 STQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLA 159 + + + R V +H + V HRD + L++++ + DF L+ Sbjct: 131 RERPPPPRLKRALVEAVARMVGDMHRAGVNHRDCYICHFLLHTDKPVSADDFRLS 185 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.144 0.447 Lambda K H 0.267 0.0446 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,449,799 Number of Sequences: 36641 Number of extensions: 670204 Number of successful extensions: 6061 Number of sequences better than 10.0: 512 Number of HSP's better than 10.0 without gapping: 928 Number of HSP's successfully gapped in prelim test: 53 Number of HSP's that attempted gapping in prelim test: 1828 Number of HSP's gapped (non-prelim): 1270 length of query: 353 length of database: 10,336,785 effective HSP length: 98 effective length of query: 255 effective length of database: 6,745,967 effective search space: 1720221585 effective search space used: 1720221585 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 60 (27.6 bits)